---
license: cc-by-nc-nd-4.0
extra_gated_fields:
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  Company: text
  Country: country
  Specific date: date_picker
  I want to use this model for:
    type: select
    options: 
      - Research
      - Education
      - label: Other
        value: other
  I agree to share generated sequences and associated data with authors before publishing: checkbox
  I agree not to file patents on any sequences generated by this model: checkbox
  I agree to use this model for non-commercial use ONLY: checkbox
---

# MeMDLM: De Novo Membrane Protein Design with Masked Diffusion Language Models

![image/png](https://cdn-uploads.huggingface.co/production/uploads/65bbea9a26c639b000501321/uWW6xnJZwQFWDS1QZNQTm.png)

Masked Diffusion Language Models (MDLMs), introduced by Sahoo et al (arxiv.org/pdf/2406.07524), provide strong generative capabilities to BERT-style models. In this work, we pre-train and fine-tune ESM-2-150M on the MDLM objective to unconditionally generate realistic, high-quality membrane protein sequences.