#version: 0.2 c c C C cc c ( = č Ċ n c N C ] ( cc ccc C c @ @ ) - CC C O c O C ) ( N c C l cc cc ) [ ) = 1 2 CC N C N n H c n ) (= C Oc CC CC n cc O CC c nc n n CC c ( - C O 2 3 C NC C n CC OCC CC CCC C OC ( [ s c NC c CCC N nc nc n nc o c cc nc O Cc B r C S N S - ] ]( [ N CC @ ] ccc nc cn n @@ ] cc n F c CC OC CC Oc n ccc Cl c 3 4 cc ncc F C ( \ CC NC -] )= CC Cc cn cc cccc n + ]([ C Nc ) \ CC n + ] n cccc 2 1 CC O S c n oc nc n CCN CC CCCC c C OCC CC S CCCC CCCC n o CS c CC CCN c sc CCC NC ccc s c s S C @ ]( N O ccc o @@ ]( CCC Oc ncc n nn n ccc n OC Oc N CCc O CCN N CCC N N cn ccc o n nc nn CCC n CCCC CC N CCN -] [ cc sc 4 5 CO CCN N NC CCC O OCC Oc +] (= O P ncc s CO Cc cnc nc S CC nccc n N CCCC 1 1 CC Nc ( / CN CC Br c O CCCN + ]( O NC S Cc CCCC NC OCC c CO P cnc n cc nn -] ) o nc CN S CS C CNC c C F CCCC CCC O CCC s ccc N CCCN cn nc O CCCC N H cn nn cc oc CCC Nc -] )(= OCC OCC c oc ncc nc )( [ = [ CCCC n cn ccn CCC OC \ [ ] \ O S CCCC Oc no nc OCC O 1 3 cc on OCC n ccnc n 2 2 NCC Cc COCC Oc CCC S s cc NCC O CN CCc CN CCO nn nn 1 4 OCC Cc 3 2 cs cn CC NCc CCCC Cc nnc n NCC Oc / [ CCS C nc sc CCCCC N nn nc c o COCC n n sc s cnc +] ) CC Sc CS CC CCCC O CCCC CCc C P CCCC Nc 3 1 +] # n s OCC NC +]# [ N OC CC OCc O CCCOc cnc o CCCCC NC O N ncc o CCC F CCN S 2 4 o ccc S i NCC NC CCCCCCCC CCCCCCCC ccc nn cnc s CC l CCCCC n NCCC n CN CCN CO CCC N Nc N n CCCCCCCC CCCC 3 5 CC F CCCC OC NCC S nc ncc NCC CCN +] =[ OCC Nc OCC OC n ncc CCS CC O CCCn CO S N CCOCC -] . @@] (= COCC NC N CCCCC CN CCC (= [ CCO P N a O B COCC O ]( \ cc nnc NCCCC NC S CCCN CCCC CCCCC CCCN CC N NS 5 6 +] . ns nc CCCC CCN CCC Sc S CCN o cc CCCC S CCCC CCOc -] )([ 3 3 COCC c CCCC CCNC NCC Nc N CCCCCC OCCOCC OCCOCC s n CCCCCCCC CCC ncn s NCC n )= [ COCC Nc O CCCO OCC F CCCCC Oc nc oc CO CCCOc CCCCCCCC CC CS Cc ] [ OCC CCN CC P ccn o N CCCCc OCCCC Oc I c co cn CCN CCc N CCCCCCCC s nc nnc s o cnc CCCC CCCCc -] )- CCCCC OC S CCC COCC S COCC OC O CCCNC CO N CS SC +] = OCC CCC C H CCCN S OCCN S O H S Sc O n CO NC N CCCNC OC n s ccn +] [ N P CCCC CCCN OCCCC n NCCC O OC OC -] )[ CCC l CCCCN S O CCCCCC s e 4 3 NCCC Nc CCC OCC nnc o S e cs cc cn oc NCC OC S H CO CCCn +]. [ CCCC CCCc CCCC CCCCN CCOCC Oc S CCc ] ) Cl CC CN CCOc CCCC CCn CCCCCCCC CCCCCCC CCCCCCCC CCCCC O CCCCc CO CCCN S SC CCC NCc CS CCC NCCCC Nc 4 1 N CCCOc CCCCC Nc COCC OCC C Br CCCC CCCOc NCC NCc - ]( CCCCCCCC NC NCCCC CCNC CCCCCCCC Oc CCCCCCCC CCCCCC COCC OCCOCC NCCOCC OCCOCC COCC Cc NCC Sc Cl C +] \ cs nn NC N CCCCC Sc CCOCC n @] (= NCCCC CCC CO B NCCN S OCCC OC N CCCCCN CCS CCc +] )[ no cc OCCC Nc nc on cn sc OCC S OCCN CCCF N OCc CCO CCN CCS Cc CN CCn CO CCCNC O CCCCCCCC CCCC CCCNC CN CCNC COC Oc 5 4 CN CCCC CCCCC S CCO CCC N CCCCCNC CCCCCCCC n CCCC Sc 4 2 CCCCCCCCCCCCCCCC CC OCC CCCN CCCCC O OCCCC CCN CCN CCCCc OC P F CC COC P OCCC S NC P CCCC CCOC CCCCCC Nc OCCC F CN CCCN NCCOCC OCCNC COCC OCCOCCOCCOCC N OCC NCC F NCCCCCC Nc OCC Sc CCC P OCC CCCOc CCCC NCc O CCNCC c onc CS CN S CCS OC N CCC SC OCC OCc CO CCCC COCCOCC OCCOc S CCNC o ncc CCCCCCCC CCOc CCCCCCCC CCCCc nn sc OCCCC O CCOCC c -]. [ CCS S NCCCC CCN OCC OCCN CCC OCCn CCOCC OCCOCC ) / @@ ]([ OCC NCc CCCCCCCC CCN OCC OCCOc NCC SC CCCCCCCC OC CN CCCc N OCCO OC O CCCCCC Sc NCCCCC Nc CCCOC n CCCCCCCC CCCCn ccn s 4 6 O CCCCNC S S S CCOc CN CCOC CCO S Br C OCCOCC NC s nnc CCCC CCS nn ccc CCCCCCCC CCNC NCCCC O OCCC NCc CCCCCCCCCCCC CCOc CO CCCNc CO CCCCn O O CS CCc CCCCCCCC Cc CCO N 23 5 COCC F ] (= NCCCCCCCC Nc CO n CCCCCCCC CCc 2 5 O CCCCCCC S CCCc NCCCC Oc CS CCNC CCCCCCCCCCCCCCCC CCNC CN CCCO NCCCC Cc NCCCCCCCC NC CN CCS CCCC CCCn )\ [ F CCOc CCCC B CS CCN @@ +]([ CCC B OC F CCN CCN NCC SCc CN N CCCC CCCCCN COC O CCCCCCCC CCCCN NCCC S CN CCNc COCCN S NCCCC CCCNc CCCCCCC Nc B H CN CCCNc CCCCCCCCCCCCCCCC CCOC 4 4 6 7 O CCCCCCCCCCC CCOCC OCCN COCC OCCN CCCCCCCC CCCCOc S CCn COCC NCc NCCC OC OCCCC Cc CCC OCc COCC OCCOc N CCCCCCCCCCC @@ +] CCCC OP ncc nn NCCOCC OCC F CCN S CCO cn sn CCOCC O NCCCC CCCNC NC NC - ](\ O Nc CN NN CS SCC -] =[ CCCCCCCC CCCNC NCCCN CCCCN CCOCC NC NCCOCC OCCNS C I S CN )( \ CN CCCOc CO Nc CCCCCCCC CCCCNC F CCn cc sn NCCCC CCCCN OCCCC Nc n scc CCCC l OCC SC CCOCC OCCOCCOCCOCC CCCCCCCC S CCCCCCCCCCCC CCCCC S CCCCC 1 0 COCC OCc CCCCCCCC Nc CN CCCNC CCCCC OCc +] / CCS CCCC NO CCN OCCCC CCNC CCCCCCCCCCCCCCCC OCC OCCCO NC 1 5 S CCCS cccc cc CN NC -])= [ OCCCO P ] . CCOCC Nc CCCCCCC OC N Oc CCCC P CCO CCCNC CCCCCCCCCCCC CCOC NCCOCCOCC OCCNS cn ncc Br CC CCOC n NCCC OCCOCC F Cc s snc CN CCCn OCC CCCn CCCCCCCC CCCc CCCCCCCC CCCOc NCCCC n NCCCN S OCCOCC OCCOc N CCNCC CCOCC OC NCCOCC Oc CC CCNCC CCOCC OCc NS C CCO NC NCCCC CCS S CCCC NCCCCCCCC CCNc COCCOCCOCC NC NCCCOCCOCC OCCCNC R e S N CCN CCC CCCC CCO OCC ONC COC n CCCCCCC Sc CO CCCS CS CCNc CCCCCCCCC Oc )- [ NCCC NCc 31 5 CCCCCCCCCCCCCCCC CCOCC @ ]([ s sc Cl Cc CO CCCCc CN CCCCc CCCC CCCCCNC OCC Br COCC CCC CCCO N OCCOCC OCC CCCCCCCCCCCCCCCC OC COCCOCCOCCOCCOCC OCCOCC s ncc CO CCCCOc COC OC CCO CCCCc NCCCC CCc OCCCC CCCCN CCCCCCCCCCCC OC CNCCC P CCCCC NS COCC OCCNC CCCCCCCC CCn CCCCN NC NO S CCCCCCCCCCCC CCN OCCOC n NCCOCCOCCOCC NC F S ] )([ OC OP CS CCCc cnn s CCCCCCCC CCOC CCCCN CCc NCCCC CCCN CCCCCCCCCCCC CCNC CC Br CCCC F NCCOCC OCCOCCOCCOCC L i N CCCCCCCCCCCC ] % CCN CCCc CCCC OCC CCCCC OCC NCCC OCC CNCC F OCCCC CCn # [ S CCCO CCC Br CO CCCCCC CCCN CCc -] \ OCCCC CCOc OCCOCC OCCOC OC OCc 12 3 OCC OCCC CCOCC OCCOc CCCCN CCOc OCCCN CC NCCCCC O 5 3 S CCCn S CCCCCC CN CCNCC CS CCCNC COCC P NCCN CCCF CCCO P NCCOCC OCCN 8 9 N NCc CCN CCOc CN CCCCN OCC CCCNC CCCN CCCNC COCC CCN CCCCCC NCc NCCOCC O CCCCCCCCC OC 5 1 O NS NC S NC n OC S CCCC CCOCC OCC CCCNc (\ [ CCCCCCCC CCCCCCc OCCCC CCCN OCCCC CCO OCCOCC OCCN CCCCCCCCCCCCCCCC NC 1 6 F CCNC ] = Cl CCN CCCCC NCc CS CCO CS CCCCCCc NCCC F NCCC l NN N NCCCC CCOc CNCC NCc OCCCC CCCCC CCCCCCCCCCCC CCCc O CCCCCCCCCCCC S CSc CCC SCC CCN CCO CN Nc CCCC CCNCC CCCC SC CCCC CCCCCn COCC OCOc OCCC OCc ns s NCCCCCCCCCCCC OP @ +]([ N NCC N OCCNC O CCCCCCCCCC Z n CN P CCCC OCc CCCC OCCOc CO CCCCOC COCC OCCOC CCS SC CCCCCCCC O NCCC P +]( / OCCC Sc co cc NCCOCC NC NCCCNCCCCN CCCNC G a CC B CCCC CCNS COC ON +] )= NCCCC CCn OCCCN S OCCCC OC OCCOCC n OCCOCC OC OCCOCC OCCNC CCCCCCCCCCCCCCCC Oc 4 7 A s O CCCCCCCCCCCCCCCC S CCNS S SSc CN n CCCN CCC ncnc n NCC CCNS NCCC SC NN Nc SCC Nc OCCCC CCc NCCO N CCCCCCCCCCCC S NCCOCC OCCOCCN NCCCCC Oc ] )\ CCCC OCCCCCCNC CNC N CCOCC Cc CCOCC OCC CCCCC NCC CCCN CCN NCC OCc CCS CCC OCCC OCC COCCOCC OCCN NCCCNCCCCN CCCN . [ C B F CCCOc S n CCC OCCOc COC N CS CCCC -] #[ CCO CCCn CCCCCCCC Sc CCCCCCCC CCCCCc NN NN CCCCCCC l OCCC P CCCCCCCCC Nc F CCOC N CCCCCn S CSC 12 34 CO CCNCC CO CCCCCCC CCCCC P CCCN CCOc CCOC P ncn o CCNCC S CCCCCCCC CCS OCCN CCc OCCN CCCOc NCCCC CCCCC NCCCC CCCCCNc OCCC l OCCOCC O CCCCCCCCCCCCCCCC CCC 56 7 ) : 5 2 F CCc O CCCCCCCCOc CN CCCS CN CCCCCCNc CCCCC SSc NO CCCOc NCCCC l CCCCCCC S CCCCCCCCCCCC CCCCN OCCOCCOCCOCC O NCCCCCCCC CCNC NCCCCCCCC CCCCNc OCCCCCC Nc CNCCCC CCOCCCCc - [ 7 8 ] )( CC I CCN CCCC CCN CCn CN CCCCCCCCNc CCOCC OCCOC CCCCC SC CCCN CCCN -] )( NCC P CCS SCC OCCN CCC OCCN CCOc OCCN CCO NCCCC CCO OCCCC CCCOc SS SSSc 5 5 F CCCc F CCCS CN CCCCC CN CCCCCC CN CCCCCCN cn on cnc nn CCOCC S CCCN NC CS CCOC COCC Sc CCCCCCCC CCCN CCCCCCCC CCO CCCCCC P NCCCC OC +]( \[ OCCCC F OCCOCC Nc CCCCCCCCCCCCCCCC CCN CCCCCCCCCCCC CCCN CCCCCCCCCCCC CCCNC OCCCO N OCCCO CCCC SCCC SCC COCCOCCOCC O [ * c H CN O CCOCC OCCOCc CCCCC F CCCCC Br CCCN CCNc CS N CCO Nc CCO CCCN CCO CCCO CCNCC CCNCC CCCO S NCCCC CCCCCNC +]( /[ OCCCC Sc OCCOCC OCCO CCCCCCCCCCCCCCCC CCCC NCCCCC OC COCCOCCOCC OC 9 1 F e F COc F CCCN N B N NCCc O NCC S CCCCN S CCCCCCNC ] # s s CCN N CN CCNS CCCC Br CCCC SCC CCCC CCCCNS OCC OS CO CCCO CO CCCNS CCOCC OCCn CCOCC OCCNC CCCCC l CCCN N CS CCCN CS CCOc NCC SCC CCO n CCNCC Nc COCC OCCNc cs nc NCCN CCc NCCCC CCOP CCCCCCC OCC OCCC Br NCCCN CCCNC OCCCC CCCCc OCCOCC OCCOCCOc CCCCCCCCCCCC CCCCc NCCS SCCNC OCCOCCOCCOCC OCCOCCOCCOCC OCCCCCCCC CCN OCCCCCCCC CCCCNC COCCOCCOCCOCCOCC O CCOCCOCCOCC OCCNC CCCCCCS Sc A u C u N CCCCCCCCCC O OC O Sc S CCCCCCCC S SCC S CCCCCN ] )[ CCC OCCc CCN CCCN CN OC CN CCCCCCCC CCCC CCCO CCOCC F CCOCC OCCNc CCOCC OCCOCCN COC S CS S 21 3 CCCCCCCC CCCOC SC F NCCCC CCNS OCCOCC F CCCCCCCCCCCC CCCO NCCOCC OCCOC NCCCCCCCC n NCCCCCCCC CCN COCCOCCOCC OCCOCCOc CCOCCOCCOCCOCCOCC OCCOCCOCCOCC NCCOCCOCCOCCOCCOCC OCCOCCOCCOCC 3 6 H g L u P t S CCCCCCC OC SC Cl CCC Cl CCCC CCN CCCOc CN CCCCOc OCC P OCC CCCO OCC OP CCOCC Sc CCCN CCCc CS CCn COCC CCCN COCC OCCC COCC OCCO COCC OCCn NCCN CCN COCCN CCNS NCCCC CCCCCN OCCCC l OCCCC CCOC OCCCC CCCn CCCCCCCCCCCCCCCC OCCCOP NCCCCN CCCNC NCCCCCCCC CCCCN COCCOCCOCC OCCO 42 6 OCCNCC Nc NCCOCCOCCOCCOCCOCC OCCOCCNC CCNCCS SCCN OCCCOCCCC OCCCOCC - ]([ F CCC S CCOC NC B OC Sc CCN NC CN CCCCNc CN CCCCCCCNc CO CCCOC CCOCC OCCO CCOCC OCCOCCOc CS Cn -] )\ NCC Br CCCCCCCC CCCCO OCCN CCN OCCN CCCCc SCC OCc +]( \ OCCOCC OCCF CCCCCCCCC O CCCCCCCCC S NCCCCCCCC CCCCNC COCCOCCOCC OCCN COCCOCCOCC OCCNC CNCCCC CCCCCN CCOCCOCCOCC n 6 2 O CCCCCCCCCCCCCC S Cn S CCCNC S CCCOc NC NS NC Sc CCC OCCCc OC OCCOC CN CCCCCCCCCNc CCCC CCSCC CO CCCCNC CCCN CCCNc CCOC Oc CCCCCCCC CCCn CCCCCCCC CCNc NCCCC NCc NCCCC CCCc CCCCCCC P OCCC SC NCCCN CCCCCCCCCCCCN OCCCC Br CCCCCCCCCCCCCCCC n CCCCCCCCCCCC CCO NCCOCC Nc NCCOCC OCCOc NCCOCC OCCNc NCCCCC NCCCCCCCNC NCCCCCCCC O COCCOC n COCCOCCOCC OCCOCc COCCOCCOCCOCCOCC OC COCCOCCOCCOCCOCC OCCO COCCOCCOCCOCCOCC OCCOCCOc COCCOCCOCCOCCOCC OCCOCCOCCOCCO CCOCCOCCOCC NC NCCCCCCCCN CCCCNC COCCOCCOCCOCCOCCOCCOCC O CCNCCSSCCN CCCCCCNCc 3 7 @ +] @ +]( F CCOCCOc N OCCOc S O S CCCCc S CCCCCCCCc o ccn cc s CCC OCCNC CCN CCNC CCN CCCCOc CCN CCCS CN CCCCCCCN CCCC CCOP CO NS COC On CS CSC NCC OCCN +] )( CCO CCCC CCS CCn CCS SCCC CCCCCCCC CCCCNc CCCCCCCC CCCCCNC NCCC Sc NCCN CCNC COCCN CCOc NCCCC CCCCc (/ [ CNCC P NCCCN CCCCCCCN NCCCN CCCCCCCCNC OCCCC SC CCCCO N CCCCCCCCCCCCCCCC O COCCC NCc CCCCCCCCCCCC CCn OCCOCCOCCOCC n NCCCCCCCC CCc COCCOCC S CCCCCCCCCCCCCC P COCCOCCOCC OCCOc NCCOCCOCCOCC Nc CNCCCC CCNCCSSCCNCCCCCCNCc CCOCCOCCOCCOCCOCC n CCOCCOCCOCCOCCOCCOCCOCCOCCOCC OCCOCCOCCNC + +]. 6 5 F CCCn G d R u S CCCCCSc S SCCNC NC O NC Nc OC OCC CN CCCF CCCC CCSC CO OCc CCOCC P CCCN CCNS Br Cc CS CCCCC CS CCCCCc CS SCCNC -] \[ NCC OCCC CCO CCCOc CCO CCCNc CCNCC F CCS SCCN CCCCCCCC P CCCCCCCC NCc CCCCCCCC CCCO CCCCN CCN @@]( \ NCCC OCc NCCN CCO NCCCN CC OCCCC S NCCO Nc CCCCCCCCCCCCCCCC S CCCCCCCCCCCCCCCC CCCCC CCCCCCCCCCCCCCCC CCOc CCCCCCCCCCCCCCCC CCO CCCCCCCCCCCCCCCC OP CCCCCCCCCCCC CCOCC CCCCCCCCCCCC CCCOc NCCS CCC NCCOCC OCCOCCOc NCCCCC NS CCCCCCCCC P NCCCCCC NCc OCCOCCOCCOCC NC NCCCCCCCC Oc NCCCCCCCC CCCN CCCCCCCCCCCCC S COCCOCCOCC OCC NCCOCCOCCOCC OCCOC CNCCCC CCOCCOCc 47 5 1 7 1 34 5 7 5 8 B C B P N i S b S Nc S NCc S NCCc S CCCCOc S CCCCCn T e CCC OCCN Cl CCNC CCN CCCCCc CCN CCCCNc CN CCCCNC CN CCCCO CN CCCCCCCCN CCCC SCc CCCC CCCNS OCC CCCOC CO OC CCOCC OCCc CCCN CCCC CS CCCCCC CS CCSC NCC CCNCC NCC OP CCOC O CCOC OC COCC OCCCCCCNC CCS CCOC CCS CCNC CCS Sc CCCCCCCC OP NO CCCCCC NO OSc OCCN CCCc CCCCCC F CCCO CCCN CCCO CCCOc NCCCC CCCn 11 8 CNCC Sc OCCCN CCc +]( - CCCCCCC NCc NCCCN CCCCCCCCC OCCOCC OCc OCCOCC OCCn OCCOCC OCCCc CCCCCCCCCCCC P CCCCCCCCCCCC Sc CCCCCCCCCCCC SC CCCCCCCCCCCC OS NCCOCC OCCCc OCCCO CCCOc OCCCCC NCc NCCOCCOCCOCC n OCCCCCCCC CCOc OCCCCCCCC CCCNC CCCCCS SCCCCC COCCOCCOCCOCCOCC Nc COCCOCCOCCOCCOCC OCCOCCOCCOCC NCCCCCCCCN CCCN NCCCCCCCCN CCCCCCCCN CNCCNCC NCc 1234 567 CCCCCCCCCCCCCCCN OC [* ]) NCCCNCCCCCCCN CCCN 1234567 89 3 8 8 8 F CCCC F CCCCc F CCCOC F CCOCCOCCOc I CC O Oc O CCCCCCCCCCCCOC S CCCCCc S CCSC @@ +]( CCC I Cl P CCN n CCN CCCn CCN CCCNc CN CCOCC CN CCCCCN CN CCOCCOCCNC OCC CCCSc CO CCCCCCOc CO OSc CCOCC OCCCc CCOCC ON CCCCC SCC COC OCc CCCN CCO CCCN CCCCN CCCN CCSc CCCN CCCCNc CS CO CS CNC CS CSc 34 6 +] - CCO CCCCNc CCNCC CCN COCC OCCCOc CCCCCCCC OCC CCCCCCCC CCOCC CCCCCCCC SC SC P NO CCCN OCCN CCn CCCO CCCOCC SCC P NCCCC OCc NCCCC CCOC NCCCC CCCCCn NCCCC CCCNS NCCCC CCCCNS OCCCN CCOc NCCCN CCCNCCCN OCCCC OCc OCCCC CCCc OCCCC CCCCCN OCCCC CCNS OCCOCC NCc OCCOCC OCCC OCCOCC OCCNc OCCO N Si H CCCCCCCCCCCCCCCC CCCCCC CCCCCCCCCCCC CCS CCCCCCCCCCCC CCOP NCCOCC n NCCOCC OC NCCCCC S CNCCC NCc CCCCCCCCC Sc OCCOCCOCCOCC OC OCCOCCOCCOCC Nc OCCOCCOCCOCC OCc CCCCCCCCCCC OCC COCCOCC OCc -]( - COCCOCCOCC S COCCOCCOCC n COCCOCCOCC Nc COCCOCCOCC OCCOC NCCOCCOCCOCC OC NCCOCCOCCOCC OCCC NCCOCCOCCOCC OCCOCCOc OCCCCCCCC O OCCCCCCCC n OCCCCCCCC OC OCCCCCCCC CCOC OCCCCCCCC CCCCOc CNCCCC NCc CNCCS CCCNCCc CCCNCCN CCCNCC [* ]. NCCCNCCCCCCCCCCCCN CCCNc NCCCNCCCCCCCCC NCCCNc ( : - -] - -]( 6 1 6 3 B B N OCCc N OCCCc O NCc O CCCCCCCCCCCCCCCCOC S CCOCC S CS S CCCF S CCCCCCCCCCCCCCCC s cnn cc occ NC Oc CCC SCc OC NC OC On Cl S 12 9 CCN P CCN CCOC CCN CCCF CN NCc CN CCCCn CN CCCCCCCCC CCCC OCCN CCCC OS CCCC OCCOC CCCC CCOS OCC OCCc CO NCc CO OS CO CCCCCCCCCCC CO CCCCCCCCCC 23 4 CCOCC CCN CCOCC SC CCCCC NCCC CCCCC NNC CCCCC OP COC F CCCN CCCn CCCN CCCCCc CCCN CCCCCCCCC Br CCOc CS P CS COC CS CCNCc CS CCNS CCOC N CCOC S 34 5 COCC CCCNC COCC CCCOc COCC CCCP CCS P CCS CCN CCS CCCCC CCCCCCCC SCC CCCCCCCC CCSC CCCCCCCC CCCCCN CCCCCCCC CCNS CCCCCCCC CCOP CCCCCCCC CCCCCOc CCCCCCCC CCCCCOC CCCCN CCCNC cs n NCCC OP NCCC OCCO NCCC OCCCNC CCCCCC Br CCCCCC CCNCC NCCN CCC COCCN CCC CCCO CCC SCC F NCCCC P NCCCC S NCCCC OCC OCCCC ON OCCCC CCCCCOc OCCO CCCNC 13 9 CCCS CCC CCCCO CCCNC 24 6 CCCCCCCCCCCCCCCC CCS CCCCCCCCCCCCCCCC OS CCCCCCCCCCCCCCCC CCSC CCCCCCCCCCCC CCCn CCCCCCCCCCCC OP CCCCCCCCCCCC CCCCCN NCCCCN CCCN NCCOCC OCCO CNCCC OCCOCC CCCCCCN NC CCCCCCN CCOc OCCOCCOCCOCC OCC OCCOCCOCCOCC OP OCCOCCOCCOCC OCCOC OCCOCCOCCOCC OCCOCCOc CCCCCCCCCCC SC OCCCO CCCN CCCCCCCCCC P NCCCCCCCC CCOCC NCCCCCCCC CCn NCCCCCCCC CCS NCCCCCCCC CCCn NCCCCCCCC CCCCn SCCC P COCCOCCOCC OCCNc NCCOCCOCCOCC OCCNC OCCCCCCCC Nc OCCCCCCCC CCc OCCCCCCCC CCO COCCOCCOCCOCCOCC OCCOC CCOCCOCCOCC F CCOCCOCCOCC Nc CCOCCOCCOCC OCc CCOCCOCCOCC OCCOCCOc NCCCNCCCCN CCCNCC CCOCCOCCOCCOCCOCC OCc COCCOCCOCCOCCOCCOCCOCC OCCNc NCCCCCCCN CCCCCCCNC NCCOCCOCCOCCOCCOCCOCCOCCOCCOCC OCCOCCNC NCCCNCCCCCCCCCCCCN CCCN 58 5 CCCNCCCCCCCCC NCCCN ) /[ * ]. + +]([ 1 8 7 6 8 1 C a F B F Cn F CS F CCNc I C N Br O NCCO O CCCCCCCCCCCCCCC O CCCCCCCCCCCCCCOC P d S COc S CNC S SCc S CCCOC S CCOCCSc ] )- n ncnc nc sn OC B Cl CCc Cl CCCN Cl CCOc CCN OCC CCN CCCNC CCN CCCCCCc CCN CCNS CN NCC CN CCCCCNc CN CCOCCOCCOCC CN CCOCCO CN CCCCCCNCc CCCC OCCc CCCC OCCO CCCC OCCCc CCCC CCCNCC CCCC OCCCNc OCC I OCC SCC OCC OCCCN OCC CCNS OCC CCCNCC CO CCCCCCCC CO CCCNCC CO CCCCCCCc CO CCCCCCCOc CNC P CNC n CCOCC OCCF CCCCC I CCCCC NCCCN COC NC COC OCC CCCN CCCCCC CCCN CCNCCN CCCN CCCCCCCCCCCCN CS Nc CS COc CS CCNCC CS CCCCc CS CCS CS CCCCCCCC CS SCc CS CCCNc CS CCOCCOCCn -] (= NCC I NCC ONC NCC OCCNS CCNC N +] )- CCO B CCO NCc CCO CCCCOc CCO CCCF CCO CCNS CCO CCCON CCO CCCCOCC CCNCC P COCC OP COCC ONC COCC ON CCCCCCCC CCNCC CCCCCCCC CCNCc CCCCCCCC CCCNS CCCCN CCC CCCCN CCCN CCCCN CCCc CCCCN CCCCCNC NO N NO CCC NO CCCO OCCN N OCCN CCCC OCCN CCNC OCCN CCCNC OCCN CCCn OCCN CCCNc NN CCN NN CCCC CCCCCC l NCCN CCCCCNC COCCN CCn CCCO NC CCCO CCCNC SCC l SCC NCc SCC Sc NCCCC CCNCC NCCCC CCCOc OCCCN CCC OCCCN CCO OCCC OCCNC OCCC OCCCCC NCCCN CCCN NCCCN CCO NCCCN CCCCCN NCCCN CCCCNCC OCCCC NCc OCCCC CCCCCn OCCOCC S OCCOCC OCCS OCCOCC OCCOCc OCCOCC OCCOCCN NCCO B CCCCO CCCn CCCCCCCCCCCCCCCC OCCC COCCC P NCCS CCCc OCCOC OC NCCOCC c NCCOCC OCCC COCCO n OCCOCCOCCOCC F OCCOCCOCCOCC OCCC OCCCO CCC CCCCCCCCCC CCNCC NCCCCCCCC CCCCc NCCCCCCCC CCCNC COCCOC O OCCCCC l OCCCCC OCc OCCCCCC P OCCCCCC Sc 41 5 COCCOCCOCC OCc COCCOCCOCC OCCC NCCOCCOCCOCC O OCCCCCCCC CCCOc OCCCCCCCC CCCCO COCCOCCOCCOCCOCC OCC COCCOCCOCCOCCOCC OCCOCCNC NCCCCCCN CCCCCCNC CCOCCOCCOCC OCCOc CCOCCOCCOCC OCCn CCOCCOCCOCC OCCNc CCOCCOCCOCC OCCOCc CCOCCOCCOCC OCCOCCC SS CCO NCCCNCCCCN CCC NCCCCCCCCN CCCCCCCCNC 10 1 ]. [ CCCCCCCCCCCCCCCCCCOCC OP OCCOCCOCC CCCNC COCCOCCOCCOCCOCCOCCOCC OC COCCOCCOCCOCCOCCOCCOCC Nc COCCOCCOCCOCCOCCOCCOCC OCCN COCCOCCOCCOCCOCCOCCOCC OCCO COCCOCCOCCOCCOCCOCCOCC OCCOCc NCCOCCOCCOCCOCCOCC OCCN COCCCCCC P OCCCCCCCCCCCC S CCOCCOCC OCCNS .[ *]. CNCCCS CCNCCc CCNCCCCNCC CCNCCCCNCC CNCCCCCCCC NCc CNCCCCCCCC CCNc NCCOCCOCCOCCOCCOCCOCCOCCOCCOCC NC NCCOCCOCCOCCOCCOCCOCCOCCOCCOCC OCCOCCOc CCCCCCCCCCCCCCCCCCO CCCOP COOS N NCCCOCCO OCCCCCNC CCCCCCCCCCCCCCCCCN OC CNCCCOCCOCC OCCCNC CCCNCCCCCCCCCCCCN CCCN NCCCNCCCCCN CCCNC * )- * ]) + +] + +][ + +].[ 2 6 3 23 B c B OCc F CCCCN F CCCNc F CCOCc F CCCCCn F CCOCCO N NCCC N OCCOC O OCc O SC O OS S P S r S COC S CNc S CCCCO S CCCCCCc S CCCCCCN S CCCSc S CCCCCCCCCCC S SCCC S CCCCCCCc S CCCCCCCCN S CCCCSc S CCCCCCCCCc S CCCCP S CCOCCOC S CCCCCCCSc S CCOCCOCC S CCCCCCCCCCP ] )(= c C o cccc cc o NC SC NC NN NC OCCO CCC OCCOC OC OCCN Cl CCCn Cl CCNc CCN OC CCN Nc CCN SC CCN CCCCCN CCN CCCNCCCN CN OCc CN NS CN CCCCCNC CN CCCNCC CN CCCCS CN CCCCCCCCCCC CN CCCCCOc CN CCCNS CN CCSS CN CCCCCCCCCCN CN CCOCCOCCN CN CCOCCNc CN CCCCCNCc CN CCCCCCCNCc CN CCOCCOCCOCCNS cn ncn CCCC OCCCN CCCC OCCn CCCC OCCCCCN CCCC OCCOCCOc OCC l OCC CCNCC OCC CCCF OCC OCCCCOc OCC CCCNS OCC OCCNS CO O CO CCCCCc CO CCCCCCc CO CCCCCCCN CO CCCCCCCCCCCCCCC CO CCCCCCCCNC CNC O CNC OC CCOCC I CCOCC CCCN CCOCC OP CCOCC CCCOCC CCOCC OCCCCc CCOCC OCCOCCC CCCCC NCCc CCCCC SCc CCCCC OCCCC CCCCC OCCCCC CCCCC OCCCCCN COC Nc COC OCCOc COC OCCS CCCN CCCCc CCCN CCS CCCN CCCOc CCCN CCCS CCCN CCCCCCN CCCN CCCCCNCCC nnc nn Br N Br CCN CS Sc CS CCCOc CS CCCn CS CCCCCCC CS CCCCOc CS CSCC CS CCCCCCCCC CS SCCC CS CCOCCn CS CCSCc CS CCCCCS CS CCCCSC CS CCCCCSC NS c NS Nc -] (=[ NCC OS CCOC Sc CCOC OCCOC CCNC S +] )(= CCO OC CCO NS CCO CCNCC CCO CCCOC CCO CCCNS COCC I COCC CCCn COCC SCC COCC OCCc COCC CCCNc COCC OS COCC OCCCc CCS n CCS CS CCS CCO CCS CCS CCS CCNc CCS CCCCNC CCS CCCNCC CCS CCOCCOCCOCCOCCOCC CCCCCCCC CCCS CCCCCCCC CCCCCn CCCCCCCC CCSCC CCCCCCCC CCCCNS CCCCCCCC OCCCCCN CCCCCCCC CCOCCOCCOCC CCCCCCCC CCOS CCCCN CCCOc CCCCN OS cs ccc NO NC NO Nc NO CCCC OCCN CCCSc NCCC OCCOc NCCC OCCCC NN P NN CCCCC NCCN CCCc COCCN P COCCN CCN COCCN CCc COCCN CCNC COCCN CCCS CCCO n CCCO Nc CCCO CCCn CCCO CCCO NCCCC SC NCCCC OCCCN 11 5 CNCC OCc CNCC CCNCCCCNCCCCNCCCCNCC OCCCN CCN OCCCN CCCc CSC P CCCCCCC F CCCCCCC OCc CCCCCCC SC CCCCCCC SCC CCCCCCC OCCCCCN OCCC OCn NCCCN CCC NCCCN CCCCCC NCCCN CCCCCCCCN OCCCC P OCCCC OCC OCCCC CCNCC OCCCC OS OCCCC CCCCCOC OCCCC CCCCCNc CCCOC OC 13 2 CCCS CCCNC CCCS CCNCCNC CCCS CCSCCCNCC NCCO OCCCCNC CNCCO NC 14 1 CSCC F CCCCO CCCCc ON P CCCCCCCCCCCCCCCC CCCCN CCCCCCCCCCCCCCCC CCNS CCCCCCCCCCCCCCCC CCCCOC CCCCCCCCCCCCCCCC CCOP CCCCCCCCCCCCCCCC CCP CCCCCCCCCCCCCCCC OCCCOC CCCCCCCCCCCCCCCC CCOS CCCCCCCCCCCCCCCC CCNCCOc CCCCCCCCCCCC NCc CCCCCCCCCCCC CCSC CCCCCCCCCCCC CCCNCC CCCCCCCCCCCC CCCCNS CCCCCCCCCCCC CCCCNCCOc NCCS CCN NCCS CCc NCCS CCNC NCCS Sc NCCCCN N NCCCCN CCC NCCCCN CCCCCCCN NCCOCC Cc NCCOCC OCCOCc NCCCCC OCC NCCCCC NCc NCCCCC Sc NCCCCC NCCCCCCN CNCCC Sc CNCCC OCCOCCOCC CNCCC OCCNCCc CNCCC OCCOCCc COCCO CCCNC CCCCCCCCC OCC CCCCCCCCC NCc CCCCCCCCC NS CCCCCCCCC NCC CCCCCCCCC SC CCCCCCCCC OS CCCCCCCCC OCCCCCN CCCCCCN CCCC SCCN CCCc SCCN CCCOc OCCOCCOCCOCC S OCCOCCOCCOCC OCCN OCCOCCOCCOCC OCCOc OCCOCCOCCOCC OCCOCC OCCOCCOCCOCC OCCS OCCOCCOCCOCC OCCOCCNc OCCCO S OCCCO CCCO OCCCCN CCc NCCCCCCCC Cc NCCCCCCCC CCCc NCCCCCCCC CCCCCC NCCCCCCCC CCNS SCCC SC COCCOC N COCCOC OCCN OCCCCC Br OCCCCC SC OCOC O OCCCCCC F OCCCCCC Br CCCOCC OCCCNCC CCCCCCCCN CCOc CCCCCCCCCCCCCCC OC CCCCCCCCCCCCCCC SC CCCCCCCCCCCCC O CCCCCCCCCCCCC Sc COCCOCC Sc CCCCCCCCCCCCCC Nc CCCCCCCCCCCCCC Sc COCCOCCOCC OCCn COCCOCCOCC OCCOCCN NCCOCCOCCOCC OCC NCCOCCOCCOCC NCc NCCCCCN CCCCCN NCCCCCN CCCCCNC OCCCCCCCC Cc OCCCCCCCC Sc OCCCCCCCC CCCCN OCCCCCCCC CCNc CNCCCC CCNCC OCCCCCN CCO CNCCCN CCCc COCCOCCOCCOCCOCC NC COCCOCCOCCOCCOCC OCc COCCOCCOCCOCCOCC OCCN COCCOCCOCCOCCOCC OCCOc COCCOCCOCCOCCOCC OCCOCc COCCCC P NCCCCCCN CCOc NCCCCCCN CCCCCN CCOCCOCCOCC O CCOCCOCCOCC OC CCOCCOCCOCC CCCNC CCOCCOCCOCC OCCN CCOCCOCCOCC ONC CCOCCOCCOCC OCCC CCOCCOCCOCC OCCCCOCC CCCCCCCCCCN CCOc NOCCO Nc 46 7 SS N CCCCCCCCCCCCN CCOc NCCOCCOCC OP NCCCNCCCCN CCCNc CCOCCOCCOCCOCCOCC Nc CCOCCOCCOCCOCCOCC OCCn CCOCCOCCOCCOCCOCC OCCOCCn CCOCCOCCOCCOCCOCC OCCOCCOCCNC CCCCCCCCCCCCCCCCC OCC 15 8 NCCCOCCOCC OCCNC NCCNCC Sc CCCCCCO CCCCc OCCOCCOCC P OCCOCCOCC OCCC COCCOCCOCCOCCOCCOCCOCC OCCC COCCOCCOCCOCCOCCOCCOCC OCCNC CCCCCCCCCCCCCCN CCOc NCCCCCCCN CCCCN NCCOCCOCCOCCOCCOCC OCC CCCCOCC CCCNC SCCCO P OCCOCCC l SCCCCCC P CCCCCCOCC CCCN 16 9 OCCCCCCCCC P OCCCCCCCCCCCCCCCC SC CSCCCC CCSC NCCCCCCCCC NCCN CNCCCS CCOCCc CCNCCCCNCC CCNCCCCN CNCCCCCCCC CCCCNc CCOCCOCCOCCOCCOCCOCCOCCOCCOCC OCCOCCOCCOc NCCNCCN CCNC CCOCCOCCO CCCCc SO ON CCNCCCS CCNC NCCCNCCCCCCCN CCCNC CCCNCCCCN CCCN CNCCCCCCCCC NCc CCCNCCNCCN CCC SCCOCCOCC P CNCCSS CCNCC CCSCCOCCOCCOCCOCCOCC OCCO NCCCOCCCC OCCCNC CCNCCCCNCCCCNCCCCN CCCCNC