diff --git a/BioModelsRAG/2data/BIOMD0000000001.txt b/BioModelsRAG/2data/BIOMD0000000001.txt deleted file mode 100644 index a372fc16aae623ce4435e2d867fd11e3de0ceef6..0000000000000000000000000000000000000000 --- a/BioModelsRAG/2data/BIOMD0000000001.txt +++ /dev/null @@ -1,224 +0,0 @@ -// Created by libAntimony v2.13.0 -model *BIOMD0000000001() - - // Compartments and Species: - compartment comp1; - species BLL in comp1, IL in comp1, AL in comp1, A in comp1, BL in comp1; - species B in comp1, DLL in comp1, D in comp1, ILL in comp1, DL in comp1; - species I in comp1, ALL in comp1; - - // Reactions: - React0: B -> BL; comp1*(kf_0*B - kr_0*BL); - React1: BL -> BLL; comp1*(kf_1*BL - kr_1*BLL); - React2: BLL -> ALL; comp1*(kf_2*BLL - kr_2*ALL); - React3: A -> AL; comp1*(kf_3*A - kr_3*AL); - React4: AL -> ALL; comp1*(kf_4*AL - kr_4*ALL); - React5: B -> A; comp1*(kf_5*B - kr_5*A); - React6: BL -> AL; comp1*(kf_6*BL - kr_6*AL); - React7: I -> IL; comp1*(kf_7*I - kr_7*IL); - React8: IL -> ILL; comp1*(kf_8*IL - kr_8*ILL); - React9: A -> I; comp1*(kf_9*A - kr_9*I); - React10: AL -> IL; comp1*(kf_10*AL - kr_10*IL); - React11: ALL -> ILL; comp1*(kf_11*ALL - kr_11*ILL); - React12: D -> DL; comp1*(kf_12*D - kr_12*DL); - React13: DL -> DLL; comp1*(kf_13*DL - kr_13*DLL); - React14: I -> D; comp1*(kf_14*I - kr_14*D); - React15: IL -> DL; comp1*(kf_15*IL - kr_15*DL); - React16: ILL -> DLL; comp1*(kf_16*ILL - kr_16*DLL); - - // Events: - RemovalACh: at time > t2: kf_13 = 0, kf_8 = 0, kf_4 = 0, kf_1 = 0, kf_12 = 0, kf_7 = 0, kf_3 = 0, kf_0 = 0; - - // Species initializations: - BLL = 0; - IL = 0; - AL = 0; - A = 0; - BL = 0; - B = 1.66057788110262e-21/comp1; - DLL = 0; - D = 0; - ILL = 0; - DL = 0; - I = 0; - ALL = 0; - - // Compartment initializations: - comp1 = 1e-16; - - // Variable initializations: - t2 = 20; - kf_0 = 3000; - kf_3 = 3000; - kf_7 = 3000; - kf_12 = 3000; - kf_1 = 1500; - kf_4 = 1500; - kf_8 = 1500; - kf_13 = 1500; - kr_0 = 8000; - kr_1 = 16000; - kf_2 = 30000; - kr_2 = 700; - kr_3 = 8.64; - kr_4 = 17.28; - kf_5 = 0.54; - kr_5 = 10800; - kf_6 = 130; - kr_6 = 2740; - kr_7 = 4; - kr_8 = 8; - kf_9 = 19.7; - kr_9 = 3.74; - kf_10 = 19.85; - kr_10 = 1.74; - kf_11 = 20; - kr_11 = 0.81; - kr_12 = 4; - kr_13 = 8; - kf_14 = 0.05; - kr_14 = 0.0012; - kf_15 = 0.05; - kr_15 = 0.0012; - kf_16 = 0.05; - kr_16 = 0.0012; - - // Other declarations: - var kf_0, kf_3, kf_7, kf_12, kf_1, kf_4, kf_8, kf_13; - const comp1, t2, kr_0, kr_1, kf_2, kr_2, kr_3, kr_4, kf_5, kr_5, kf_6, kr_6; - const kr_7, kr_8, kf_9, kr_9, kf_10, kr_10, kf_11, kr_11, kr_12, kr_13; - const kf_14, kr_14, kf_15, kr_15, kf_16, kr_16; - - // Display Names: - comp1 is "compartment1"; - BLL is "BasalACh2"; - IL is "IntermediateACh"; - AL is "ActiveACh"; - A is "Active"; - BL is "BasalACh"; - B is "Basal"; - DLL is "DesensitisedACh2"; - D is "Desensitised"; - ILL is "IntermediateACh2"; - DL is "DesensitisedACh"; - I is "Intermediate"; - ALL is "ActiveACh2"; - RemovalACh is "removal of ACh"; - - // SBO terms: - comp1.sboTerm = 290 - BLL.sboTerm = 297 - IL.sboTerm = 297 - AL.sboTerm = 297 - A.sboTerm = 420 - BL.sboTerm = 297 - B.sboTerm = 420 - DLL.sboTerm = 297 - D.sboTerm = 420 - ILL.sboTerm = 297 - DL.sboTerm = 297 - I.sboTerm = 420 - ALL.sboTerm = 297 - kf_0.sboTerm = 35 - kf_3.sboTerm = 35 - kf_7.sboTerm = 35 - kf_12.sboTerm = 35 - kf_1.sboTerm = 35 - kf_4.sboTerm = 35 - kf_8.sboTerm = 35 - kf_13.sboTerm = 35 - kr_0.sboTerm = 38 - kr_1.sboTerm = 38 - kf_2.sboTerm = 35 - kr_2.sboTerm = 38 - kr_3.sboTerm = 38 - kr_4.sboTerm = 38 - kf_5.sboTerm = 35 - kr_5.sboTerm = 38 - kf_6.sboTerm = 35 - kr_6.sboTerm = 38 - kr_7.sboTerm = 38 - kr_8.sboTerm = 38 - kf_9.sboTerm = 35 - kr_9.sboTerm = 38 - kf_10.sboTerm = 35 - kr_10.sboTerm = 38 - kf_11.sboTerm = 35 - kr_11.sboTerm = 38 - kr_12.sboTerm = 38 - kr_13.sboTerm = 38 - kf_14.sboTerm = 35 - kr_14.sboTerm = 38 - kf_15.sboTerm = 35 - kr_15.sboTerm = 38 - kf_16.sboTerm = 35 - kr_16.sboTerm = 38 - React0.sboTerm = 177 - React1.sboTerm = 177 - React2.sboTerm = 181 - React3.sboTerm = 177 - React4.sboTerm = 177 - React5.sboTerm = 181 - React6.sboTerm = 181 - React7.sboTerm = 177 - React8.sboTerm = 177 - React9.sboTerm = 181 - React10.sboTerm = 181 - React11.sboTerm = 181 - React12.sboTerm = 177 - React13.sboTerm = 177 - React14.sboTerm = 181 - React15.sboTerm = 181 - React16.sboTerm = 181 - - // CV terms: - comp1 identity "http://identifiers.org/go/GO:0031594" - BLL hypernym "http://identifiers.org/interpro/IPR002394", - "http://identifiers.org/go/GO:0005892" - IL hypernym "http://identifiers.org/interpro/IPR002394", - "http://identifiers.org/go/GO:0005892" - AL hypernym "http://identifiers.org/interpro/IPR002394", - "http://identifiers.org/go/GO:0005892" - A hypernym "http://identifiers.org/interpro/IPR002394", - "http://identifiers.org/go/GO:0005892" - BL hypernym "http://identifiers.org/interpro/IPR002394", - "http://identifiers.org/go/GO:0005892" - B hypernym "http://identifiers.org/interpro/IPR002394", - "http://identifiers.org/go/GO:0005892" - DLL hypernym "http://identifiers.org/interpro/IPR002394", - "http://identifiers.org/go/GO:0005892" - D hypernym "http://identifiers.org/interpro/IPR002394", - "http://identifiers.org/go/GO:0005892" - ILL hypernym "http://identifiers.org/interpro/IPR002394", - "http://identifiers.org/go/GO:0005892" - DL hypernym "http://identifiers.org/interpro/IPR002394", - "http://identifiers.org/go/GO:0005892" - I hypernym "http://identifiers.org/interpro/IPR002394", - "http://identifiers.org/go/GO:0005892" - ALL hypernym "http://identifiers.org/interpro/IPR002394", - "http://identifiers.org/go/GO:0005892" - React0 identity "http://identifiers.org/go/GO:0042166" - React1 identity "http://identifiers.org/go/GO:0042166" - React2 identity "http://identifiers.org/go/GO:0004889" - React3 identity "http://identifiers.org/go/GO:0042166" - React4 identity "http://identifiers.org/go/GO:0042166" - React5 identity "http://identifiers.org/go/GO:0004889" - React6 identity "http://identifiers.org/go/GO:0004889" - React7 identity "http://identifiers.org/go/GO:0042166" - React8 identity "http://identifiers.org/go/GO:0042166" - React9 identity "http://identifiers.org/go/GO:0004889" - React10 identity "http://identifiers.org/go/GO:0004889" - React11 identity "http://identifiers.org/go/GO:0004889" - React12 identity "http://identifiers.org/go/GO:0042166" - React13 identity "http://identifiers.org/go/GO:0042166" -end - -BIOMD0000000001 is "Edelstein1996 - EPSP ACh event" - -BIOMD0000000001 model_entity_is "http://identifiers.org/biomodels.db/MODEL6613849442" -BIOMD0000000001 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000001" -BIOMD0000000001 description "http://identifiers.org/pubmed/8983160" -BIOMD0000000001 hypernym "http://identifiers.org/go/GO:0007274", - "http://identifiers.org/go/GO:0007166", - "http://identifiers.org/go/GO:0019226" -BIOMD0000000001 taxon "http://identifiers.org/taxonomy/7787" diff --git a/BioModelsRAG/__init__.py b/BioModelsRAG/__init__.py deleted file mode 100644 index 74ca525c2c72610f83ecffde4008ccd00b4f84f8..0000000000000000000000000000000000000000 --- a/BioModelsRAG/__init__.py +++ /dev/null @@ -1,19 +0,0 @@ -__version__ = "0.1.0" -__author__ = "Bhavyahshree Navaneetha Krishnan" - -from langchain_text_splitters import CharacterTextSplitter -import os -import chromadb -from chromadb.utils import embedding_functions -import ollama - -import splitBioModels -import createVectorDB -import createDocuments -# Import functions from other modules -from splitBioModels import splitBioModels -from createVectorDB import createVectorDB -from createDocuments import createDocuments - -# Define __all__ to specify which names are publicly accessible -__all__ = ['splitBioModels', 'createVectorDB', 'createDocuments'] diff --git a/BioModelsRAG/__pycache__/__init__.cpython-311.pyc b/BioModelsRAG/__pycache__/__init__.cpython-311.pyc deleted file mode 100644 index 510b1f11d02cbeeeb0361863633ef98990ab7b63..0000000000000000000000000000000000000000 Binary files a/BioModelsRAG/__pycache__/__init__.cpython-311.pyc and /dev/null differ diff --git a/BioModelsRAG/data/BIOMD0000000001.txt b/BioModelsRAG/data/BIOMD0000000001.txt deleted file mode 100644 index a372fc16aae623ce4435e2d867fd11e3de0ceef6..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000001.txt +++ /dev/null @@ -1,224 +0,0 @@ -// Created by libAntimony v2.13.0 -model *BIOMD0000000001() - - // Compartments and Species: - compartment comp1; - species BLL in comp1, IL in comp1, AL in comp1, A in comp1, BL in comp1; - species B in comp1, DLL in comp1, D in comp1, ILL in comp1, DL in comp1; - species I in comp1, ALL in comp1; - - // Reactions: - React0: B -> BL; comp1*(kf_0*B - kr_0*BL); - React1: BL -> BLL; comp1*(kf_1*BL - kr_1*BLL); - React2: BLL -> ALL; comp1*(kf_2*BLL - kr_2*ALL); - React3: A -> AL; comp1*(kf_3*A - kr_3*AL); - React4: AL -> ALL; comp1*(kf_4*AL - kr_4*ALL); - React5: B -> A; comp1*(kf_5*B - kr_5*A); - React6: BL -> AL; comp1*(kf_6*BL - kr_6*AL); - React7: I -> IL; comp1*(kf_7*I - kr_7*IL); - React8: IL -> ILL; comp1*(kf_8*IL - kr_8*ILL); - React9: A -> I; comp1*(kf_9*A - kr_9*I); - React10: AL -> IL; comp1*(kf_10*AL - kr_10*IL); - React11: ALL -> ILL; comp1*(kf_11*ALL - kr_11*ILL); - React12: D -> DL; comp1*(kf_12*D - kr_12*DL); - React13: DL -> DLL; comp1*(kf_13*DL - kr_13*DLL); - React14: I -> D; comp1*(kf_14*I - kr_14*D); - React15: IL -> DL; comp1*(kf_15*IL - kr_15*DL); - React16: ILL -> DLL; comp1*(kf_16*ILL - kr_16*DLL); - - // Events: - RemovalACh: at time > t2: kf_13 = 0, kf_8 = 0, kf_4 = 0, kf_1 = 0, kf_12 = 0, kf_7 = 0, kf_3 = 0, kf_0 = 0; - - // Species initializations: - BLL = 0; - IL = 0; - AL = 0; - A = 0; - BL = 0; - B = 1.66057788110262e-21/comp1; - DLL = 0; - D = 0; - ILL = 0; - DL = 0; - I = 0; - ALL = 0; - - // Compartment initializations: - comp1 = 1e-16; - - // Variable initializations: - t2 = 20; - kf_0 = 3000; - kf_3 = 3000; - kf_7 = 3000; - kf_12 = 3000; - kf_1 = 1500; - kf_4 = 1500; - kf_8 = 1500; - kf_13 = 1500; - kr_0 = 8000; - kr_1 = 16000; - kf_2 = 30000; - kr_2 = 700; - kr_3 = 8.64; - kr_4 = 17.28; - kf_5 = 0.54; - kr_5 = 10800; - kf_6 = 130; - kr_6 = 2740; - kr_7 = 4; - kr_8 = 8; - kf_9 = 19.7; - kr_9 = 3.74; - kf_10 = 19.85; - kr_10 = 1.74; - kf_11 = 20; - kr_11 = 0.81; - kr_12 = 4; - kr_13 = 8; - kf_14 = 0.05; - kr_14 = 0.0012; - kf_15 = 0.05; - kr_15 = 0.0012; - kf_16 = 0.05; - kr_16 = 0.0012; - - // Other declarations: - var kf_0, kf_3, kf_7, kf_12, kf_1, kf_4, kf_8, kf_13; - const comp1, t2, kr_0, kr_1, kf_2, kr_2, kr_3, kr_4, kf_5, kr_5, kf_6, kr_6; - const kr_7, kr_8, kf_9, kr_9, kf_10, kr_10, kf_11, kr_11, kr_12, kr_13; - const kf_14, kr_14, kf_15, kr_15, kf_16, kr_16; - - // Display Names: - comp1 is "compartment1"; - BLL is "BasalACh2"; - IL is "IntermediateACh"; - AL is "ActiveACh"; - A is "Active"; - BL is "BasalACh"; - B is "Basal"; - DLL is "DesensitisedACh2"; - D is "Desensitised"; - ILL is "IntermediateACh2"; - DL is "DesensitisedACh"; - I is "Intermediate"; - ALL is "ActiveACh2"; - RemovalACh is "removal of ACh"; - - // SBO terms: - comp1.sboTerm = 290 - BLL.sboTerm = 297 - IL.sboTerm = 297 - AL.sboTerm = 297 - A.sboTerm = 420 - BL.sboTerm = 297 - B.sboTerm = 420 - DLL.sboTerm = 297 - D.sboTerm = 420 - ILL.sboTerm = 297 - DL.sboTerm = 297 - I.sboTerm = 420 - ALL.sboTerm = 297 - kf_0.sboTerm = 35 - kf_3.sboTerm = 35 - kf_7.sboTerm = 35 - kf_12.sboTerm = 35 - kf_1.sboTerm = 35 - kf_4.sboTerm = 35 - kf_8.sboTerm = 35 - kf_13.sboTerm = 35 - kr_0.sboTerm = 38 - kr_1.sboTerm = 38 - kf_2.sboTerm = 35 - kr_2.sboTerm = 38 - kr_3.sboTerm = 38 - kr_4.sboTerm = 38 - kf_5.sboTerm = 35 - kr_5.sboTerm = 38 - kf_6.sboTerm = 35 - kr_6.sboTerm = 38 - kr_7.sboTerm = 38 - kr_8.sboTerm = 38 - kf_9.sboTerm = 35 - kr_9.sboTerm = 38 - kf_10.sboTerm = 35 - kr_10.sboTerm = 38 - kf_11.sboTerm = 35 - kr_11.sboTerm = 38 - kr_12.sboTerm = 38 - kr_13.sboTerm = 38 - kf_14.sboTerm = 35 - kr_14.sboTerm = 38 - kf_15.sboTerm = 35 - kr_15.sboTerm = 38 - kf_16.sboTerm = 35 - kr_16.sboTerm = 38 - React0.sboTerm = 177 - React1.sboTerm = 177 - React2.sboTerm = 181 - React3.sboTerm = 177 - React4.sboTerm = 177 - React5.sboTerm = 181 - React6.sboTerm = 181 - React7.sboTerm = 177 - React8.sboTerm = 177 - React9.sboTerm = 181 - React10.sboTerm = 181 - React11.sboTerm = 181 - React12.sboTerm = 177 - React13.sboTerm = 177 - React14.sboTerm = 181 - React15.sboTerm = 181 - React16.sboTerm = 181 - - // CV terms: - comp1 identity "http://identifiers.org/go/GO:0031594" - BLL hypernym "http://identifiers.org/interpro/IPR002394", - "http://identifiers.org/go/GO:0005892" - IL hypernym "http://identifiers.org/interpro/IPR002394", - "http://identifiers.org/go/GO:0005892" - AL hypernym "http://identifiers.org/interpro/IPR002394", - "http://identifiers.org/go/GO:0005892" - A hypernym "http://identifiers.org/interpro/IPR002394", - "http://identifiers.org/go/GO:0005892" - BL hypernym "http://identifiers.org/interpro/IPR002394", - "http://identifiers.org/go/GO:0005892" - B hypernym "http://identifiers.org/interpro/IPR002394", - "http://identifiers.org/go/GO:0005892" - DLL hypernym "http://identifiers.org/interpro/IPR002394", - "http://identifiers.org/go/GO:0005892" - D hypernym "http://identifiers.org/interpro/IPR002394", - "http://identifiers.org/go/GO:0005892" - ILL hypernym "http://identifiers.org/interpro/IPR002394", - "http://identifiers.org/go/GO:0005892" - DL hypernym "http://identifiers.org/interpro/IPR002394", - "http://identifiers.org/go/GO:0005892" - I hypernym "http://identifiers.org/interpro/IPR002394", - "http://identifiers.org/go/GO:0005892" - ALL hypernym "http://identifiers.org/interpro/IPR002394", - "http://identifiers.org/go/GO:0005892" - React0 identity "http://identifiers.org/go/GO:0042166" - React1 identity "http://identifiers.org/go/GO:0042166" - React2 identity "http://identifiers.org/go/GO:0004889" - React3 identity "http://identifiers.org/go/GO:0042166" - React4 identity "http://identifiers.org/go/GO:0042166" - React5 identity "http://identifiers.org/go/GO:0004889" - React6 identity "http://identifiers.org/go/GO:0004889" - React7 identity "http://identifiers.org/go/GO:0042166" - React8 identity "http://identifiers.org/go/GO:0042166" - React9 identity "http://identifiers.org/go/GO:0004889" - React10 identity "http://identifiers.org/go/GO:0004889" - React11 identity "http://identifiers.org/go/GO:0004889" - React12 identity "http://identifiers.org/go/GO:0042166" - React13 identity "http://identifiers.org/go/GO:0042166" -end - -BIOMD0000000001 is "Edelstein1996 - EPSP ACh event" - -BIOMD0000000001 model_entity_is "http://identifiers.org/biomodels.db/MODEL6613849442" -BIOMD0000000001 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000001" -BIOMD0000000001 description "http://identifiers.org/pubmed/8983160" -BIOMD0000000001 hypernym "http://identifiers.org/go/GO:0007274", - "http://identifiers.org/go/GO:0007166", - "http://identifiers.org/go/GO:0019226" -BIOMD0000000001 taxon "http://identifiers.org/taxonomy/7787" diff --git a/BioModelsRAG/data/BIOMD0000000002.txt b/BioModelsRAG/data/BIOMD0000000002.txt deleted file mode 100644 index 809ba11be2fab031cc9eb60920ae91b22b9399d3..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000002.txt +++ /dev/null @@ -1,155 +0,0 @@ -// Created by libAntimony v2.13.0 -model *BIOMD0000000002() - - // Compartments and Species: - compartment comp1; - species BLL in comp1, IL in comp1, AL in comp1, A in comp1, BL in comp1; - species B in comp1, DLL in comp1, D in comp1, ILL in comp1, DL in comp1; - species I in comp1, ALL in comp1, L in comp1; - - // Reactions: - React0: B + L -> BL; comp1*(kf_0*B*L - kr_0*BL); - React1: BL + L -> BLL; comp1*(kf_1*BL*L - kr_1*BLL); - React2: BLL -> ALL; comp1*(kf_2*BLL - kr_2*ALL); - React3: A + L -> AL; comp1*(kf_3*A*L - kr_3*AL); - React4: AL + L -> ALL; comp1*(kf_4*AL*L - kr_4*ALL); - React5: B -> A; comp1*(kf_5*B - kr_5*A); - React6: BL -> AL; comp1*(kf_6*BL - kr_6*AL); - React7: I + L -> IL; comp1*(kf_7*I*L - kr_7*IL); - React8: IL + L -> ILL; comp1*(kf_8*IL*L - kr_8*ILL); - React9: A -> I; comp1*(kf_9*A - kr_9*I); - React10: AL -> IL; comp1*(kf_10*AL - kr_10*IL); - React11: ALL -> ILL; comp1*(kf_11*ALL - kr_11*ILL); - React12: D + L -> DL; comp1*(kf_12*D*L - kr_12*DL); - React13: DL + L -> DLL; comp1*(kf_13*DL*L - kr_13*DLL); - React14: I -> D; comp1*(kf_14*I - kr_14*D); - React15: IL -> DL; comp1*(kf_15*IL - kr_15*DL); - React16: ILL -> DLL; comp1*(kf_16*ILL - kr_16*DLL); - - // Species initializations: - BLL = 0; - IL = 0; - AL = 0; - A = 0; - BL = 0; - B = 1e-22/comp1; - DLL = 0; - D = 0; - ILL = 0; - DL = 0; - I = 0; - ALL = 0; - L = 1e-21/comp1; - - // Compartment initializations: - comp1 = 1e-16; - - // Variable initializations: - kf_0 = 300000000; - kr_0 = 8000; - kf_1 = 150000000; - kr_1 = 16000; - kf_2 = 30000; - kr_2 = 700; - kf_3 = 300000000; - kr_3 = 8.64; - kf_4 = 150000000; - kr_4 = 17.28; - kf_5 = 0.54; - kr_5 = 10800; - kf_6 = 130; - kr_6 = 2740; - kf_7 = 300000000; - kr_7 = 4; - kf_8 = 150000000; - kr_8 = 8; - kf_9 = 19.7; - kr_9 = 3.74; - kf_10 = 19.85; - kr_10 = 1.74; - kf_11 = 20; - kr_11 = 0.81; - kf_12 = 300000000; - kr_12 = 4; - kf_13 = 150000000; - kr_13 = 8; - kf_14 = 0.05; - kr_14 = 0.0012; - kf_15 = 0.05; - kr_15 = 0.0012; - kf_16 = 0.05; - kr_16 = 0.0012; - - // Other declarations: - const comp1, kf_0, kr_0, kf_1, kr_1, kf_2, kr_2, kf_3, kr_3, kf_4, kr_4; - const kf_5, kr_5, kf_6, kr_6, kf_7, kr_7, kf_8, kr_8, kf_9, kr_9, kf_10; - const kr_10, kf_11, kr_11, kf_12, kr_12, kf_13, kr_13, kf_14, kr_14, kf_15; - const kr_15, kf_16, kr_16; - - // Display Names: - comp1 is "compartment1"; - BLL is "BasalACh2"; - IL is "IntermediateACh"; - AL is "ActiveACh"; - A is "Active"; - BL is "BasalACh"; - B is "Basal"; - DLL is "DesensitisedACh2"; - D is "Desensitised"; - ILL is "IntermediateACh2"; - DL is "DesensitisedACh"; - I is "Intermediate"; - ALL is "ActiveACh2"; - L is "ACh"; - - // CV terms: - comp1 identity "http://identifiers.org/go/GO:0031594" - BLL hypernym "http://identifiers.org/interpro/IPR002394", - "http://identifiers.org/go/GO:0005892" - IL hypernym "http://identifiers.org/interpro/IPR002394", - "http://identifiers.org/go/GO:0005892" - AL hypernym "http://identifiers.org/interpro/IPR002394", - "http://identifiers.org/go/GO:0005892" - A hypernym "http://identifiers.org/go/GO:0005892" - BL hypernym "http://identifiers.org/interpro/IPR002394", - "http://identifiers.org/go/GO:0005892" - B hypernym "http://identifiers.org/interpro/IPR002394", - "http://identifiers.org/go/GO:0005892" - DLL hypernym "http://identifiers.org/go/GO:0005892" - D hypernym "http://identifiers.org/interpro/IPR002394", - "http://identifiers.org/go/GO:0005892" - ILL hypernym "http://identifiers.org/interpro/IPR002394", - "http://identifiers.org/go/GO:0005892" - DL hypernym "http://identifiers.org/interpro/IPR002394", - "http://identifiers.org/go/GO:0005892" - I hypernym "http://identifiers.org/interpro/IPR002394", - "http://identifiers.org/go/GO:0005892" - ALL hypernym "http://identifiers.org/interpro/IPR002394", - "http://identifiers.org/go/GO:0005892" - L identity "http://identifiers.org/chebi/CHEBI:15355", - "http://identifiers.org/kegg.compound/C01996" - React0 identity "http://identifiers.org/go/GO:0042166" - React1 identity "http://identifiers.org/go/GO:0042166" - React2 identity "http://identifiers.org/go/GO:0004889" - React3 identity "http://identifiers.org/go/GO:0042166" - React4 identity "http://identifiers.org/go/GO:0042166" - React5 identity "http://identifiers.org/go/GO:0004889" - React6 identity "http://identifiers.org/go/GO:0004889" - React7 identity "http://identifiers.org/go/GO:0042166" - React8 identity "http://identifiers.org/go/GO:0042166" - React9 identity "http://identifiers.org/go/GO:0004889" - React10 identity "http://identifiers.org/go/GO:0004889" - React11 identity "http://identifiers.org/go/GO:0004889" - React12 identity "http://identifiers.org/go/GO:0042166" - React13 identity "http://identifiers.org/go/GO:0042166" -end - -BIOMD0000000002 is "Edelstein1996 - EPSP ACh species" - -BIOMD0000000002 model_entity_is "http://identifiers.org/biomodels.db/MODEL6614086398" -BIOMD0000000002 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000002" -BIOMD0000000002 description "http://identifiers.org/pubmed/8983160" -BIOMD0000000002 taxon "http://identifiers.org/taxonomy/7787" -BIOMD0000000002 hypernym "http://identifiers.org/go/GO:0007166", - "http://identifiers.org/go/GO:0007274", - "http://identifiers.org/go/GO:0019226" diff --git a/BioModelsRAG/data/BIOMD0000000003.txt b/BioModelsRAG/data/BIOMD0000000003.txt deleted file mode 100644 index c2a1caa4dba162fb4c168d3db7350b320ad7adc2..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000003.txt +++ /dev/null @@ -1,124 +0,0 @@ -// Created by libAntimony v2.13.0 -model *BIOMD0000000003() - - // Compartments and Species: - compartment cell; - species C in cell, M in cell, X in cell; - - // Assignment Rules: - V1 := C*VM1*(C + Kc)^-1; - V3 := M*VM3; - - // Reactions: - reaction1: => C; cell*reaction1_vi; - reaction2: C => ; C*cell*reaction2_kd; - reaction3: C => ; C*cell*reaction3_vd*X*(C + reaction3_Kd)^-1; - reaction4: => M; cell*(1 + -1*M)*V1*(reaction4_K1 + -1*M + 1)^-1; - reaction5: M => ; cell*M*reaction5_V2*(reaction5_K2 + M)^-1; - reaction6: => X; cell*V3*(1 + -1*X)*(reaction6_K3 + -1*X + 1)^-1; - reaction7: X => ; cell*reaction7_V4*X*(reaction7_K4 + X)^-1; - - // Species initializations: - C = 0.01; - C has substance_per_volume; - M = 0.01; - M has substance_per_volume; - X = 0.01; - X has substance_per_volume; - - // Compartment initializations: - cell = 1; - cell has volume; - - // Variable initializations: - VM1 = 3; - Kc = 0.5; - VM3 = 1; - reaction1_vi = 0.025; - reaction2_kd = 0.01; - reaction3_vd = 0.25; - reaction3_Kd = 0.02; - reaction4_K1 = 0.005; - reaction5_V2 = 1.5; - reaction5_K2 = 0.005; - reaction6_K3 = 0.005; - reaction7_K4 = 0.005; - reaction7_V4 = 0.5; - - // Other declarations: - var V1, V3; - const cell, VM1, Kc, VM3; - - // Unit definitions: - unit volume = litre; - unit substance = mole; - unit substance_per_volume = mole / litre; - - // Display Names: - C is "Cyclin"; - M is "CDC-2 Kinase"; - X is "Cyclin Protease"; - reaction1 is "creation of cyclin"; - reaction2 is "default degradation of cyclin"; - reaction3 is "cdc2 kinase triggered degration of cyclin"; - reaction4 is "activation of cdc2 kinase"; - reaction5 is "deactivation of cdc2 kinase"; - reaction6 is "activation of cyclin protease"; - reaction7 is "deactivation of cyclin protease"; - - // SBO terms: - cell.sboTerm = 290 - C.sboTerm = 252 - M.sboTerm = 252 - X.sboTerm = 297 - V1.sboTerm = 186 - VM1.sboTerm = 25 - Kc.sboTerm = 27 - V3.sboTerm = 186 - VM3.sboTerm = 186 - reaction1.sboTerm = 393 - reaction1_vi.sboTerm = 48 - reaction2.sboTerm = 179 - reaction2_kd.sboTerm = 22 - reaction3.sboTerm = 179 - reaction3_vd.sboTerm = 186 - reaction3_Kd.sboTerm = 27 - reaction4.sboTerm = 330 - reaction4_K1.sboTerm = 27 - reaction5.sboTerm = 216 - reaction5_V2.sboTerm = 186 - reaction5_K2.sboTerm = 27 - reaction6.sboTerm = 216 - reaction6_K3.sboTerm = 27 - reaction7.sboTerm = 330 - reaction7_K4.sboTerm = 27 - reaction7_V4.sboTerm = 186 - - // CV terms: - cell identity "http://identifiers.org/go/GO:0005623" - C hypernym "http://identifiers.org/uniprot/Q4KLA0", - "http://identifiers.org/interpro/IPR006670" - M version "http://identifiers.org/uniprot/P24033", - "http://identifiers.org/uniprot/P35567" - X hypernym "http://identifiers.org/go/GO:0005680" - X version "http://identifiers.org/reactome/REACT_7165.1" - reaction1 hypernym "http://identifiers.org/go/GO:0006412" - reaction2 hypernym "http://identifiers.org/go/GO:0008054" - reaction3 hypernym "http://identifiers.org/go/GO:0008054" - reaction4 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0045737", - "http://identifiers.org/go/GO:0006470" - reaction5 hypernym "http://identifiers.org/ec-code/2.7.10.2", - "http://identifiers.org/go/GO:0045736", - "http://identifiers.org/go/GO:0006468" -end - -BIOMD0000000003 is "Goldbeter1991 - Min Mit Oscil" - -BIOMD0000000003 model_entity_is "http://identifiers.org/biomodels.db/MODEL6614271263" -BIOMD0000000003 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000003" -BIOMD0000000003 description "http://identifiers.org/pubmed/1833774" -BIOMD0000000003 homolog "http://identifiers.org/reactome/REACT_152" -BIOMD0000000003 hypernym "http://identifiers.org/kegg.pathway/hsa04110", - "http://identifiers.org/go/GO:0000278" -BIOMD0000000003 taxon "http://identifiers.org/taxonomy/8292" diff --git a/BioModelsRAG/data/BIOMD0000000004.txt b/BioModelsRAG/data/BIOMD0000000004.txt deleted file mode 100644 index 37c23d2a08c2593df3e83659070f3122ccf30277..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000004.txt +++ /dev/null @@ -1,102 +0,0 @@ -// Created by libAntimony v2.13.0 -model *BIOMD0000000004() - - // Compartments and Species: - compartment cell; - species C in cell, M in cell, X in cell, MI in cell, XI in cell; - - // Assignment Rules: - V1 := C*VM1*(C + Kc)^-1; - V3 := M*VM3; - - // Reactions: - reaction1: => C; cell*reaction1_vi; - reaction2: C => ; C*cell*reaction2_kd; - reaction3: C => ; C*cell*reaction3_vd*X*(C + reaction3_Kd)^-1; - reaction4: MI => M; cell*MI*V1*(reaction4_K1 + MI)^-1; - reaction5: M => MI; cell*M*reaction5_V2*(reaction5_K2 + M)^-1; - reaction6: XI => X; cell*V3*XI*(reaction6_K3 + XI)^-1; - reaction7: X => XI; cell*reaction7_V4*X*(reaction7_K4 + X)^-1; - - // Species initializations: - C = 0.01; - C has substance_per_volume; - M = 0.01; - M has substance_per_volume; - X = 0.01; - X has substance_per_volume; - MI = 0.99; - MI has substance_per_volume; - XI = 0.99; - XI has substance_per_volume; - - // Compartment initializations: - cell = 1; - cell has volume; - - // Variable initializations: - VM1 = 3; - Kc = 0.5; - VM3 = 1; - reaction1_vi = 0.025; - reaction2_kd = 0.01; - reaction3_vd = 0.25; - reaction3_Kd = 0.02; - reaction4_K1 = 0.005; - reaction5_V2 = 1.5; - reaction5_K2 = 0.005; - reaction6_K3 = 0.005; - reaction7_K4 = 0.005; - reaction7_V4 = 0.5; - - // Other declarations: - var V1, V3; - const cell, VM1, Kc, VM3; - - // Unit definitions: - unit volume = litre; - unit substance = mole; - unit substance_per_volume = mole / litre; - - // Display Names: - C is "Cyclin"; - M is "Active CDC-2 Kinase"; - X is "Active Cyclin Protease"; - MI is "Inactive CDC-2 Kinase"; - XI is "Inactive Cyclin Protease"; - reaction1 is "creation of cyclin"; - reaction2 is "default degradation of cyclin"; - reaction3 is "cdc2 kinase triggered degration of cyclin"; - reaction4 is "activation of cdc2 kinase"; - reaction5 is "deactivation of cdc2 kinase"; - reaction6 is "activation of cyclin protease"; - reaction7 is "deactivation of cyclin protease"; - - // CV terms: - cell identity "http://identifiers.org/obo.go/GO:0005623" - C hypernym "http://identifiers.org/interpro/IPR006670" - M version "http://identifiers.org/uniprot/P24033", - "http://identifiers.org/uniprot/P35567" - MI version "http://identifiers.org/uniprot/P24033", - "http://identifiers.org/uniprot/P35567" - reaction1 hypernym "http://identifiers.org/obo.go/GO:0006412" - reaction2 hypernym "http://identifiers.org/obo.go/GO:0008054" - reaction3 hypernym "http://identifiers.org/obo.go/GO:0008054" - reaction4 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/obo.go/GO:0045737", - "http://identifiers.org/obo.go/GO:0006470" - reaction5 hypernym "http://identifiers.org/ec-code/2.7.10.2", - "http://identifiers.org/obo.go/GO:0045736", - "http://identifiers.org/obo.go/GO:0006468" -end - -BIOMD0000000004 is "Goldbeter1991 - Min Mit Oscil, Expl Inact" - -BIOMD0000000004 model_entity_is "http://identifiers.org/biomodels.db/MODEL6614389071" -BIOMD0000000004 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000004" -BIOMD0000000004 description "http://identifiers.org/pubmed/1833774" -BIOMD0000000004 origin "http://identifiers.org/biomodels.db/BIOMD0000000003" -BIOMD0000000004 hypernym "http://identifiers.org/kegg.pathway/hsa04110", - "http://identifiers.org/obo.go/GO:0000278" -BIOMD0000000004 homolog "http://identifiers.org/reactome/REACT_152" -BIOMD0000000004 taxon "http://identifiers.org/taxonomy/8292" diff --git a/BioModelsRAG/data/BIOMD0000000005.txt b/BioModelsRAG/data/BIOMD0000000005.txt deleted file mode 100644 index aa5f21eb247e58aa3e0949fb1264b07461f8c069..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000005.txt +++ /dev/null @@ -1,114 +0,0 @@ -// Created by libAntimony v2.13.0 -model *BIOMD0000000005() - - // Compartments and Species: - compartment cell; - species $EmptySet in cell, C2 in cell, CP in cell, M in cell, pM in cell; - species Y in cell, YP in cell, $YT in cell, $CT in cell; - - // Assignment Rules: - YT := Y + YP + M + pM; - CT := C2 + CP + M + pM; - - // Reactions: - Reaction1: M => C2 + YP; cell*Reaction1_k6*M; - Reaction2: C2 => CP; cell*C2*Reaction2_k8notP; - Reaction3: CP => C2; cell*CP*Reaction3_k9; - Reaction4: CP + Y => pM; cell*CP*Reaction4_k3*Y; - Reaction5: M => pM; cell*Reaction5_k5notP*M; - Reaction6: $EmptySet => Y; cell*Reaction6_k1aa; - Reaction7: Y => $EmptySet; cell*Reaction7_k2*Y; - Reaction8: YP => $EmptySet; cell*Reaction8_k7*YP; - Reaction9: pM => M; cell*pM*(Reaction9_k4prime + Reaction9_k4*(M/CT)^2); - - // Species initializations: - EmptySet = 0; - C2 = 0; - CP = 0.75/cell; - M = 0; - pM = 0.25/cell; - Y = 0; - YP = 0; - - // Compartment initializations: - cell = 1; - - // Variable initializations: - Reaction1_k6 = 1; - Reaction2_k8notP = 1000000; - Reaction3_k9 = 1000; - Reaction4_k3 = 200; - Reaction5_k5notP = 0; - Reaction6_k1aa = 0.015; - Reaction7_k2 = 0; - Reaction8_k7 = 0.6; - Reaction9_k4 = 180; - Reaction9_k4prime = 0.018; - - // Other declarations: - const cell; - - // Display Names: - C2 is "cdc2k"; - CP is "cdc2k-P"; - M is "p-cyclin_cdc2"; - pM is "p-cyclin_cdc2-p"; - Y is "cyclin"; - YP is "p-cyclin"; - YT is "total_cyclin"; - CT is "total_cdc2"; - Reaction1 is "cyclin_cdc2k dissociation"; - Reaction2 is "cdc2k phosphorylation"; - Reaction3 is "cdc2k dephosphorylation"; - Reaction4 is "cyclin cdc2k-p association"; - Reaction5 is "deactivation of cdc2 kinase"; - Reaction6 is "cyclin biosynthesis"; - Reaction7 is "default degradation of cyclin"; - Reaction8 is "cdc2 kinase triggered degration of cyclin"; - Reaction9 is "activation of cdc2 kinase"; - - // CV terms: - cell identity "http://identifiers.org/obo.go/GO:0005623" - C2 hypernym "http://identifiers.org/uniprot/P04551" - CP hypernym "http://identifiers.org/uniprot/P04551" - M part "http://identifiers.org/uniprot/P04551", - "http://identifiers.org/interpro/IPR006670" - pM part "http://identifiers.org/uniprot/P04551", - "http://identifiers.org/interpro/IPR006670" - Y hypernym "http://identifiers.org/interpro/IPR006670" - YP hypernym "http://identifiers.org/interpro/IPR006670" - YT hypernym "http://identifiers.org/interpro/IPR006670" - CT hypernym "http://identifiers.org/uniprot/P04551" - Reaction1 version "http://identifiers.org/reactome/REACT_6308" - Reaction1 hypernym "http://identifiers.org/obo.go/GO:0000079" - Reaction2 hypernym "http://identifiers.org/ec-code/2.7.11.1", - "http://identifiers.org/obo.go/GO:0006468" - Reaction3 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/obo.go/GO:0006470" - Reaction4 version "http://identifiers.org/reactome/REACT_6216", - "http://identifiers.org/reactome/REACT_6308" - Reaction5 hypernym "http://identifiers.org/ec-code/2.7.10.2", - "http://identifiers.org/obo.go/GO:0006468", - "http://identifiers.org/obo.go/GO:0045736" - Reaction5 version "http://identifiers.org/reactome/REACT_3178", - "http://identifiers.org/reactome/REACT_6327" - Reaction6 hypernym "http://identifiers.org/obo.go/GO:0006412" - Reaction7 hypernym "http://identifiers.org/obo.go/GO:0008054" - Reaction8 hypernym "http://identifiers.org/obo.go/GO:0008054" - Reaction9 version "http://identifiers.org/reactome/REACT_6257", - "http://identifiers.org/reactome/REACT_6175", - "http://identifiers.org/reactome/REACT_6294" - Reaction9 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/obo.go/GO:0006470", - "http://identifiers.org/obo.go/GO:0045737" -end - -BIOMD0000000005 is "Tyson1991 - Cell Cycle 6 var" - -BIOMD0000000005 model_entity_is "http://identifiers.org/biomodels.db/MODEL6614644188" -BIOMD0000000005 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000005" -BIOMD0000000005 description "http://identifiers.org/pubmed/1831270" -BIOMD0000000005 taxon "http://identifiers.org/taxonomy/33154" -BIOMD0000000005 hypernym "http://identifiers.org/kegg.pathway/sce04111", - "http://identifiers.org/obo.go/GO:0000278" -BIOMD0000000005 version "http://identifiers.org/reactome/REACT_152" diff --git a/BioModelsRAG/data/BIOMD0000000006.txt b/BioModelsRAG/data/BIOMD0000000006.txt deleted file mode 100644 index 830a1c7ecd9646eb55fea96c460b0806ec3b6b71..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000006.txt +++ /dev/null @@ -1,66 +0,0 @@ -// Created by libAntimony v2.13.0 -model *BIOMD0000000006() - - // Compartments and Species: - compartment cell; - substanceOnly species $EmptySet in cell, $u in cell, $v in cell, $z in cell; - - // Assignment Rules: - alpha := k4prime/k4; - z := v - u; - - // Rate Rules: - u' = k4*(v - u)*(alpha + u^2) - k6*u; - v' = kappa - k6*u; - - // Reactions: - Reaction1: $EmptySet => $z; kappa; - Reaction2: $u => $EmptySet; k6*u; - Reaction3: $z => $u; k4*z*(k4prime/k4 + u^2); - - // Species initializations: - EmptySet = 1/cell; - u = 0; - v = 0; - - // Compartment initializations: - cell = 1; - - // Variable initializations: - k4 = 180; - k6 = 1; - kappa = 0.015; - k4prime = 0.018; - - // Other declarations: - var alpha; - const cell, k4, k6, kappa, k4prime; - - // SBO terms: - EmptySet.sboTerm = 291 - u.sboTerm = 297 - v.sboTerm = 297 - z.sboTerm = 297 - Reaction1.sboTerm = 205 - Reaction2.sboTerm = 179 - Reaction3.sboTerm = 176 - - // CV terms: - cell identity "http://identifiers.org/obo.go/GO:0005623" - u property "http://identifiers.org/obo.go/GO:0004693" - u hypernym "http://identifiers.org/obo.go/GO:0031387" - v version "http://identifiers.org/uniprot/P04551" - v version "http://identifiers.org/obo.go/GO:0031387" - v property "http://identifiers.org/obo.go/GO:0004693" - z version "http://identifiers.org/uniprot/P04551" -end - -BIOMD0000000006 is "Tyson1991 - Cell Cycle 2 var" - -BIOMD0000000006 model_entity_is "http://identifiers.org/biomodels.db/MODEL6614715255" -BIOMD0000000006 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000006" -BIOMD0000000006 description "http://identifiers.org/pubmed/1831270" -BIOMD0000000006 taxon "http://identifiers.org/taxonomy/33154" -BIOMD0000000006 identity "http://identifiers.org/kegg.pathway/sce04111" -BIOMD0000000006 hypernym "http://identifiers.org/obo.go/GO:0000278" -BIOMD0000000006 version "http://identifiers.org/reactome/REACT_152" diff --git a/BioModelsRAG/data/BIOMD0000000007.txt b/BioModelsRAG/data/BIOMD0000000007.txt deleted file mode 100644 index d22e00febb2aff7e36fcca72f726f7a1309b7398..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000007.txt +++ /dev/null @@ -1,266 +0,0 @@ -// Created by libAntimony v2.13.0 -model *BIOMD0000000007() - - // Compartments and Species: - compartment Cell; - substanceOnly species UbE in Cell, UbE2 in Cell, Wee1 in Cell, Cdc25 in Cell; - substanceOnly species G2K in Cell, R in Cell, G1K in Cell, IE in Cell, PG2 in Cell; - substanceOnly species G1R in Cell, G2R in Cell, PG2R in Cell, $SPF in Cell; - substanceOnly species $MPF in Cell, $IEB in Cell, $UbEB in Cell, $UbE2B in Cell; - substanceOnly species $Wee1B in Cell, $Cdc25B in Cell, $Rum1Total in Cell; - substanceOnly species $Cdc13Total in Cell, $Cig2Total in Cell; - - // Assignment Rules: - SPF := Cig1 + alpha*G1K + MPF; - MPF := G2K + beta*PG2; - IEB := 1 - IE; - UbEB := 1 - UbE; - UbE2B := 1 - UbE2; - Wee1B := 1 - Wee1; - Cdc25B := 1 - Cdc25; - Rum1Total := G1R + G2R + PG2R + R; - Cdc13Total := G2K + G2R + PG2 + PG2R; - Cig2Total := G1K + G1R; - k2 := UbE*V2 + (1 - UbE)*V2prime; - k6 := UbE2*V6 + (1 - UbE2)*V6prime; - kwee := Vwprime*(1 - Wee1) + Vw*Wee1; - k25 := Cdc25*V25 + (1 - Cdc25)*V25prime; - - // Rate Rules: - Mass' = Mass*mu; - - // Reactions: - G2K_Creation: => G2K; k1; - G1K_Creation: => G1K; k5; - Cdc2Phos: G2K -> PG2; G2K*kwee - k25*PG2; - G2R_Creation: G2K + R -> G2R; G2K*k7*R - G2R*k7r; - PG2R_Creation: PG2 + R -> PG2R; k7*PG2*R - k7r*PG2R; - Rum1DegInG2R: G2R => G2K; G2R*k4; - Rum1Deg: R => ; k4*R; - Rum1DegInPG2R: PG2R => PG2; k4*PG2R; - RumDegInG1R: G1R => G1K; G1R*k4; - G2K_dissoc: G2K => ; G2K*k2; - PG2_dissoc: PG2 => ; k2*PG2; - G1K_Dissociation: G1K => ; G1K*k6; - PG2R_Dissociation: PG2R => R; k2prime*PG2R; - G2R_Dissociation: G2R => R; G2R*k2prime; - G1R_Dissociation: G1R => R; G1R*k6prime; - G1R_Binding: G1K + R -> G1R; G1K*k8*R - G1R*k8r; - G2R_Dissociation_UbE: G2R => R; G2R*k2; - PG2R_Dissociation_UbE: PG2R => R; k2*PG2R; - Rum1_Production: => R; k3; - Rum1_Deg_SPF: R => ; kp*Mass*R*SPF/(Kmp + R); - IE_Reaction: $IEB -> IE; IEB*ki*MPF/(IEB + Kmi) - IE*kir/(IE + Kmir); - UbE_Reaction: $UbEB -> UbE; IE*ku*UbEB/(Kmu + UbEB) - kur*UbE/(Kmur + UbE); - UbE2_Reaction: $UbE2B -> UbE2; ku2*MPF*UbE2B/(Kmu2 + UbE2B) - kur2*UbE2/(Kmur2 + UbE2); - Wee1_Reaction: $Wee1B -> Wee1; kwr*Wee1B/(Kmwr + Wee1B) - kw*MPF*Wee1/(Kmw + Wee1); - Cdc25_Reaction: $Cdc25B -> Cdc25; Cdc25B*kc*MPF/(Cdc25B + Kmc) - Cdc25*kcr/(Cdc25 + Kmcr); - - // Events: - Start: at 60 after SPF >= 0.1: kp = kp/2; - Division: at UbE <= 0.1: Mass = Mass/2, kp = 2*kp; - - // Species initializations: - UbE = 0.11/Cell; - UbE2 = 0; - Wee1 = 0; - Cdc25 = 0; - G2K = 0; - R = 0.4/Cell; - G1K = 0; - IE = 0; - PG2 = 0; - G1R = 0; - G2R = 0; - PG2R = 0; - - // Compartment initializations: - Cell = 1; - Cell has volume; - - // Variable initializations: - Cig1 = 0; - alpha = 0.25; - beta = 0.05; - kp = 3.25; - Mass = 0.49; - mu = 0.00495; - k1 = 0.015; - k2prime = 0.05; - k3 = 0.09375; - k4 = 0.1875; - k5 = 0.00175; - k6prime = 0; - k7 = 100; - k7r = 0.1; - k8 = 10; - k8r = 0.1; - kc = 1; - kcr = 0.25; - ki = 0.4; - kir = 0.1; - ku = 0.2; - kur = 0.1; - ku2 = 1; - kur2 = 0.3; - kw = 1; - kwr = 0.25; - V2 = 0.25; - V2prime = 0.0075; - V6 = 7.5; - V6prime = 0.0375; - V25 = 0.5; - V25prime = 0.025; - Vw = 0.35; - Vwprime = 0.035; - Kmc = 0.1; - Kmcr = 0.1; - Kmi = 0.01; - Kmir = 0.01; - Kmp = 0.001; - Kmu = 0.01; - Kmur = 0.01; - Kmu2 = 0.05; - Kmur2 = 0.05; - Kmw = 0.1; - Kmwr = 0.1; - - // Other declarations: - var kp, Mass, k2, k6, kwee, k25; - const Cell, Cig1, alpha, beta, mu, k1, k2prime, k3, k4, k5, k6prime, k7; - const k7r, k8, k8r, kc, kcr, ki, kir, ku, kur, ku2, kur2, kw, kwr, V2, V2prime; - const V6, V6prime, V25, V25prime, Vw, Vwprime, Kmc, Kmcr, Kmi, Kmir, Kmp; - const Kmu, Kmur, Kmu2, Kmur2, Kmw, Kmwr; - - // Unit definitions: - unit time_unit = 60 second; - unit volume = litre; - - // Display Names: - time_unit is "minutes"; - UbE is "ubiquitinProtease1"; - UbE2 is "ubiquitinProtease2"; - G2K is "Cdc13_Cdc2"; - R is "FreeRum1"; - G1K is "Cig2_Cdc2"; - IE is "IntermediaryEnzyme"; - PG2 is "Cdc13_P-Cdc2"; - G1R is "Cig2_Cdc2_Rum1"; - G2R is "Cdc13_Cdc2_Rum1"; - PG2R is "Cdc13_P-Cdc2_Rum1"; - SPF is "S-phasePromotingFactor"; - MPF is "M-phasePromotingFactor"; - IEB is "BoundIntermediaryEnzyme"; - UbEB is "BoundUbiquitinProtease1"; - UbE2B is "BoundUbiquitinProtease2"; - Wee1B is "BoundWee1"; - Cdc25B is "BoundCdc25"; - Rum1Total is "TotalRum1"; - Cdc13Total is "TotalCdc13"; - Cig2Total is "TotalCig2"; - Start is "S-Phase Start"; - Division is "Cell Division"; - k2prime is "k2'"; - k6prime is "k6'"; - V2prime is "V2'"; - V6prime is "V6'"; - V25prime is "V25'"; - Vwprime is "Vw'"; - G2K_Creation is "Cdc13_Cdc2 creation"; - G1K_Creation is "Cig2_Cdc2 creation"; - Cdc2Phos is "Cdc2 phosphorylation"; - G2R_Creation is "binding of Rum1 with Cdc13_Cdc2"; - PG2R_Creation is "binding of Rum1 with Cdc13_P-Cdc2"; - Rum1DegInG2R is "Rum1 degradation in Rum1_Cdc13_Cdc2"; - Rum1Deg is "Rum1 degradation in solution"; - Rum1DegInPG2R is "Rum1 degradation in Rum1_Cdc13_P-Cdc2"; - RumDegInG1R is "Rum1 degradation in Rum1_Cig2_Cdc2"; - G2K_dissoc is "Cdc13 degradation in Cdc13_Cdc2"; - PG2_dissoc is "Cdc13 degradation in Cdc13_P-Cdc2"; - G1K_Dissociation is "Cig2 degradation in Cig2_Cdc2"; - PG2R_Dissociation is "Cdc13 degradation in Rum1_Cdc13_P-Cdc2"; - G2R_Dissociation is "Cdc13 degradation in Rum1_Cdc13_Cdc2"; - G1R_Dissociation is "Cig2 degradation in Rum1_Cig2_Cdc2"; - G1R_Binding is "Binding of Rum1 to Cig2_Cdc2"; - G2R_Dissociation_UbE is "UbE mediated degradation of Cdc13_Cdc2 in Rum1_Cdc13_Cdc2"; - PG2R_Dissociation_UbE is "UbE mediated degradation of Cdc13_Cdc2 in Rum1_Cdc13_P-Cdc2"; - Rum1_Production is "Rum1 creation"; - Rum1_Deg_SPF is "Rum1 degradation by SPF"; - IE_Reaction is "IE production & degradation"; - UbE_Reaction is "UbE production & degradation"; - UbE2_Reaction is "UbE2 production & degradation"; - Wee1_Reaction is "Wee1 production & degradation"; - Cdc25_Reaction is "Cdc25 production & degradation"; - - // CV terms: - Cell identity "http://identifiers.org/go/GO:0005623" - UbE hypernym "http://identifiers.org/go/GO:0000502" - UbE2 hypernym "http://identifiers.org/go/GO:0000502" - Wee1 version "http://identifiers.org/uniprot/P30290", - "http://identifiers.org/uniprot/P07527" - Cdc25 identity "http://identifiers.org/uniprot/P06652" - G2K part "http://identifiers.org/uniprot/P04551", - "http://identifiers.org/uniprot/P10815" - R hypernym "http://identifiers.org/uniprot/P40380" - G1K part "http://identifiers.org/uniprot/P04551", - "http://identifiers.org/uniprot/P36630" - PG2 part "http://identifiers.org/uniprot/P10815", - "http://identifiers.org/uniprot/P04551" - G1R part "http://identifiers.org/uniprot/P04551", - "http://identifiers.org/uniprot/P36630", - "http://identifiers.org/uniprot/P40380" - G2R part "http://identifiers.org/uniprot/P04551", - "http://identifiers.org/uniprot/P10815", - "http://identifiers.org/uniprot/P40380" - PG2R part "http://identifiers.org/uniprot/P10815", - "http://identifiers.org/uniprot/P04551", - "http://identifiers.org/uniprot/P40380" - SPF part "http://identifiers.org/uniprot/P04551", - "http://identifiers.org/uniprot/P10815", - "http://identifiers.org/uniprot/P36630" - MPF part "http://identifiers.org/uniprot/P10815", - "http://identifiers.org/uniprot/P04551" - UbEB hypernym "http://identifiers.org/go/GO:0000502" - UbE2B hypernym "http://identifiers.org/go/GO:0000502" - Wee1B version "http://identifiers.org/uniprot/P07527", - "http://identifiers.org/uniprot/P30290" - Cdc25B hypernym "http://identifiers.org/uniprot/P06652" - Rum1Total identity "http://identifiers.org/uniprot/P40380" - Cdc13Total identity "http://identifiers.org/uniprot/P10815" - Cig2Total identity "http://identifiers.org/uniprot/P36630" - Cdc2Phos part "http://identifiers.org/reactome/REACT_6294", - "http://identifiers.org/reactome/REACT_6327" - Cdc2Phos part "http://identifiers.org/reactome/REACT_6257", - "http://identifiers.org/reactome/REACT_6178" - Cdc2Phos hypernym "http://identifiers.org/ec-code/2.7.10.2", - "http://identifiers.org/go/GO:0006468" - G2R_Creation hypernym "http://identifiers.org/go/GO:0006461" - PG2R_Creation hypernym "http://identifiers.org/go/GO:0006461" - Rum1DegInG2R hypernym "http://identifiers.org/go/GO:0030163" - Rum1Deg hypernym "http://identifiers.org/go/GO:0030163" - Rum1DegInPG2R hypernym "http://identifiers.org/go/GO:0030163" - RumDegInG1R hypernym "http://identifiers.org/go/GO:0030163" - G2K_dissoc hypernym "http://identifiers.org/go/GO:0008054" - PG2_dissoc hypernym "http://identifiers.org/go/GO:0008054" - G1K_Dissociation hypernym "http://identifiers.org/go/GO:0008054" - PG2R_Dissociation hypernym "http://identifiers.org/go/GO:0008054" - G2R_Dissociation hypernym "http://identifiers.org/go/GO:0008054" - G1R_Dissociation hypernym "http://identifiers.org/go/GO:0008054" - G1R_Binding hypernym "http://identifiers.org/go/GO:0006461" - G2R_Dissociation_UbE hypernym "http://identifiers.org/kegg.pathway/spo04120", - "http://identifiers.org/go/GO:0030163" - PG2R_Dissociation_UbE hypernym "http://identifiers.org/kegg.pathway/spo04120", - "http://identifiers.org/go/GO:0030163" - Rum1_Deg_SPF hypernym "http://identifiers.org/go/GO:0030163" -end - -BIOMD0000000007 is "Novak1997 - Cell Cycle" - -BIOMD0000000007 model_entity_is "http://identifiers.org/biomodels.db/MODEL6614787694" -BIOMD0000000007 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000007" -BIOMD0000000007 description "http://identifiers.org/pubmed/9256450" -BIOMD0000000007 origin "http://identifiers.org/pubmed/10395816" -BIOMD0000000007 taxon "http://identifiers.org/taxonomy/4896" -BIOMD0000000007 hypernym "http://identifiers.org/kegg.pathway/ko04110", - "http://identifiers.org/go/GO:0000278" -BIOMD0000000007 homolog "http://identifiers.org/reactome/REACT_152" diff --git a/BioModelsRAG/data/BIOMD0000000008.txt b/BioModelsRAG/data/BIOMD0000000008.txt deleted file mode 100644 index b8f93c665b31f708fcccf06658aced8f106aaa23..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000008.txt +++ /dev/null @@ -1,121 +0,0 @@ -// Created by libAntimony v2.13.0 -model *BIOMD0000000008() - - // Compartments and Species: - compartment Cell; - species C in Cell, X in Cell, M in Cell, Y in Cell, Z in Cell; - - // Assignment Rules: - V1 := C*V1p*(C + K6)^-1; - V3 := M*V3p; - - // Reactions: - reaction1: => C; reaction1_vi; - reaction2: C => ; C*reaction2_k1*X*(C + reaction2_K5)^-1; - reaction3: C => ; C*reaction3_kd; - reaction4: => M; (1 + -1*M)*V1*(reaction4_K1 + -1*M + 1)^-1; - reaction5: M => ; M*reaction5_V2*(reaction5_K2 + M)^-1; - reaction6: => X; V3*(1 + -1*X)*(reaction6_K3 + -1*X + 1)^-1; - reaction7: X => ; reaction7_V4*X*(reaction7_K4 + X)^-1; - reaction8: C + Y => Z; reaction8_a1*C*Y; - reaction9: Z => C + Y; reaction9_a2*Z; - reaction10: Z => C; reaction10_alpha*reaction10_d1*Z; - reaction11: Z => Y; reaction11_alpha*reaction11_kd*Z; - reaction12: => Y; reaction12_vs; - reaction13: Y => ; reaction13_d1*Y; - - // Species initializations: - C = 0; - C has substance_per_volume; - X = 0; - X has substance_per_volume; - M = 0; - M has substance_per_volume; - Y = 1/Cell; - Y has substance_per_volume; - Z = 1/Cell; - Z has substance_per_volume; - - // Compartment initializations: - Cell = 1; - Cell has volume; - - // Variable initializations: - V1p = 0.75; - K6 = 0.3; - V3p = 0.3; - reaction1_vi = 0.1; - reaction2_k1 = 0.5; - reaction2_K5 = 0.02; - reaction3_kd = 0.02; - reaction4_K1 = 0.1; - reaction5_V2 = 0.25; - reaction5_K2 = 0.1; - reaction6_K3 = 0.2; - reaction7_K4 = 0.1; - reaction7_V4 = 0.1; - reaction8_a1 = 0.05; - reaction9_a2 = 0.05; - reaction10_alpha = 0.1; - reaction10_d1 = 0.05; - reaction11_kd = 0.02; - reaction11_alpha = 0.1; - reaction12_vs = 0.2; - reaction13_d1 = 0.05; - - // Other declarations: - var V1, V3; - const Cell, V1p, K6, V3p; - - // Unit definitions: - unit volume = litre; - unit substance = mole; - unit substance_per_volume = mole / litre; - - // Display Names: - C is "cyclin"; - X is "protease"; - M is "cdc2k"; - Y is "cyclin inhibitor"; - Z is "complex inhibitor-cyclin"; - reaction1 is "creation of cyclin"; - reaction2 is "cdc2 kinase triggered degration of cyclin"; - reaction3 is "default degradation of cyclin"; - reaction4 is "activation of cdc2 kinase"; - reaction5 is "deactivation of cdc2 kinase"; - reaction6 is "activation of cyclin protease"; - reaction7 is "deactivation of cyclin protease"; - reaction10 is "desinhibition of cyclin"; - reaction11 is "degradation of inhibited cyclin"; - reaction12 is "creation of cyclin inhibitor"; - reaction13 is "degradation of cyclin inhibitor"; - - // CV terms: - Cell identity "http://identifiers.org/go/GO:0005737" - C identity "http://identifiers.org/interpro/IPR006670" - X property "http://identifiers.org/go/GO:0008233" - M version "http://identifiers.org/uniprot/P35567", - "http://identifiers.org/uniprot/P24033" - Z part "http://identifiers.org/interpro/IPR006670" - reaction1 hypernym "http://identifiers.org/go/GO:0006412" - reaction2 hypernym "http://identifiers.org/go/GO:0008054" - reaction3 hypernym "http://identifiers.org/go/GO:0008054" - reaction4 hypernym "http://identifiers.org/go/GO:0045737" - reaction5 hypernym "http://identifiers.org/go/GO:0045736" - reaction9 hypernym "http://identifiers.org/go/GO:0043241" - reaction10 hypernym "http://identifiers.org/go/GO:0044257" - reaction11 hypernym "http://identifiers.org/go/GO:0008054" - reaction12 hypernym "http://identifiers.org/go/GO:0006412" - reaction13 hypernym "http://identifiers.org/go/GO:0044257" -end - -BIOMD0000000008 is "Gardner1998 - Cell Cycle Goldbeter" - -BIOMD0000000008 model_entity_is "http://identifiers.org/biomodels.db/MODEL6614879888" -BIOMD0000000008 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000008" -BIOMD0000000008 description "http://identifiers.org/pubmed/9826676" -BIOMD0000000008 origin "http://identifiers.org/biomodels.db/BIOMD0000000003", - "http://identifiers.org/biomodels.db/BIOMD0000000004" -BIOMD0000000008 hypernym "http://identifiers.org/go/GO:0000278" -BIOMD0000000008 taxon "http://identifiers.org/taxonomy/8292" -BIOMD0000000008 homolog "http://identifiers.org/reactome/REACT_152" diff --git a/BioModelsRAG/data/BIOMD0000000009.txt b/BioModelsRAG/data/BIOMD0000000009.txt deleted file mode 100644 index f4960d986770bba9a9967a579c6af419173e7a4b..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000009.txt +++ /dev/null @@ -1,250 +0,0 @@ -// Created by libAntimony v2.13.0 -model *BIOMD0000000009() - - // Compartments and Species: - compartment compartment_; - species E1 in compartment_, E2 in compartment_, KKK in compartment_, P_KKK in compartment_; - species KK in compartment_, P_KK in compartment_, PP_KK in compartment_; - species K in compartment_, P_K in compartment_, PP_K in compartment_, KPase in compartment_; - species KKPase in compartment_, E1_KKK in compartment_, E2_P_KKK in compartment_; - species P_KKK_KK in compartment_, P_KKK_P_KK in compartment_, PP_KK_K in compartment_; - species PP_KK_P_K in compartment_, KKPase_PP_KK in compartment_, KKPase_P_KK in compartment_; - species KPase_PP_K in compartment_, KPase_P_K in compartment_, $K_PP_norm in compartment_; - species $KK_PP_norm in compartment_, $KKK_P_norm in compartment_, $rel_K_PP_max in compartment_; - - // Assignment Rules: - K_PP_norm := (PP_K + KPase_PP_K)/(PP_K + P_K + K + PP_KK_K + PP_KK_P_K + KPase_PP_K + KPase_P_K); - KK_PP_norm := (PP_KK + PP_KK_K + PP_KK_P_K + KKPase_PP_KK)/(PP_KK + P_KK + KK + PP_KK_K + PP_KK_P_K + P_KKK_KK + P_KKK_P_KK + KKPase_PP_KK + KKPase_P_KK); - KKK_P_norm := (P_KKK + P_KKK_KK + P_KKK_P_KK)/(KKK + P_KKK + P_KKK_KK + P_KKK_P_KK); - rel_K_PP_max := K_PP_norm/K_PP_norm_max; - - // Reactions: - r1a: KKK + E1 -> E1_KKK; compartment_*(r1a_a1*E1*KKK - r1a_d1*E1_KKK); - r1b: E1_KKK => E1 + P_KKK; compartment_*r1b_k2*E1_KKK; - r2a: P_KKK + E2 -> E2_P_KKK; compartment_*(r2a_a2*E2*P_KKK - r2a_d2*E2_P_KKK); - r2b: E2_P_KKK => E2 + KKK; compartment_*r2b_k2*E2_P_KKK; - r3a: KK + P_KKK -> P_KKK_KK; compartment_*(r3a_a3*KK*P_KKK - r3a_d3*P_KKK_KK); - r3b: P_KKK_KK => P_KK + P_KKK; compartment_*r3b_k3*P_KKK_KK; - r4a: P_KK + KKPase -> KKPase_P_KK; compartment_*(r4a_a4*P_KK*KKPase - r4a_d4*KKPase_P_KK); - r4b: KKPase_P_KK => KK + KKPase; compartment_*r4b_k4*KKPase_P_KK; - r5a: P_KK + P_KKK -> P_KKK_P_KK; compartment_*(r5a_a5*P_KK*P_KKK - r5a_d5*P_KKK_P_KK); - r5b: P_KKK_P_KK => PP_KK + P_KKK; compartment_*r5b_k5*P_KKK_P_KK; - r6a: PP_KK + KKPase -> KKPase_PP_KK; compartment_*(r6a_a6*PP_KK*KKPase - r6a_d6*KKPase_PP_KK); - r6b: KKPase_PP_KK => P_KK + KKPase; compartment_*r6b_k6*KKPase_PP_KK; - r7a: K + PP_KK -> PP_KK_K; compartment_*(r7a_a7*K*PP_KK - r7a_d7*PP_KK_K); - r7b: PP_KK_K => P_K + PP_KK; compartment_*r7b_k7*PP_KK_K; - r8a: P_K + KPase -> KPase_P_K; compartment_*(r8a_a8*P_K*KPase - r8a_d8*KPase_P_K); - r8b: KPase_P_K => K + KPase; compartment_*r8b_k8*KPase_P_K; - r9a: P_K + PP_KK -> PP_KK_P_K; compartment_*(r9a_a9*P_K*PP_KK - r9a_d9*PP_KK_P_K); - r9b: PP_KK_P_K => PP_KK + PP_K; compartment_*r9b_k9*PP_KK_P_K; - r10a: PP_K + KPase -> KPase_PP_K; compartment_*(r10a_a10*PP_K*KPase - r10a_d10*KPase_PP_K); - r10b: KPase_PP_K => P_K + KPase; compartment_*r10b_k10*KPase_PP_K; - - // Species initializations: - E1 = 3e-05; - E2 = 0.0003; - KKK = 0.003; - P_KKK = 0; - KK = 1.2; - P_KK = 0; - PP_KK = 0; - K = 1.2; - P_K = 0; - PP_K = 0; - KPase = 0.12; - KKPase = 0.0003; - E1_KKK = 0; - E2_P_KKK = 0; - P_KKK_KK = 0; - P_KKK_P_KK = 0; - PP_KK_K = 0; - PP_KK_P_K = 0; - KKPase_PP_KK = 0; - KKPase_P_KK = 0; - KPase_PP_K = 0; - KPase_P_K = 0; - - // Compartment initializations: - compartment_ = 4e-12; - - // Variable initializations: - K_PP_norm_max = 0.900049; - r1a_a1 = 1000; - r1a_d1 = 150; - r1b_k2 = 150; - r2a_a2 = 1000; - r2a_d2 = 150; - r2b_k2 = 150; - r3a_a3 = 1000; - r3a_d3 = 150; - r3b_k3 = 150; - r4a_a4 = 1000; - r4a_d4 = 150; - r4b_k4 = 150; - r5a_a5 = 1000; - r5a_d5 = 150; - r5b_k5 = 150; - r6a_a6 = 1000; - r6a_d6 = 150; - r6b_k6 = 150; - r7a_a7 = 1000; - r7a_d7 = 150; - r7b_k7 = 150; - r8a_a8 = 1000; - r8a_d8 = 150; - r8b_k8 = 150; - r9a_a9 = 1000; - r9a_d9 = 150; - r9b_k9 = 150; - r10a_a10 = 1000; - r10a_d10 = 150; - r10b_k10 = 150; - - // Other declarations: - const compartment_, K_PP_norm_max; - - // Unit definitions: - unit substance = 1e-6 mole; - - // Display Names: - substance is "micromole"; - E1 is "MAPKKK activator (Ras)"; - E2 is "MAPKKK inactivator"; - KKK is "Mos"; - P_KKK is "Mos-P"; - KK is "Mek1"; - P_KK is "Mek1-P"; - PP_KK is "Mek1-PP"; - K is "Erk2"; - P_K is "Erk2-P"; - PP_K is "Erk2-PP"; - KPase is "MAPK-Pase"; - KKPase is "MAPKK-Pase"; - E1_KKK is "E1_Mos"; - E2_P_KKK is "E2_Mos-P"; - P_KKK_KK is "P-Mos_Mek1"; - P_KKK_P_KK is "P-Mos_P-Mek1"; - PP_KK_K is "PP-Mek1_Erk2"; - PP_KK_P_K is "PP-Mek1_P-Erk2"; - KKPase_PP_KK is "MAPKK-Pase_PP-Mek1"; - KKPase_P_KK is "MAPKK-Pase_P-Mek1"; - KPase_PP_K is "MAPK-Pase_PP-Erk2"; - KPase_P_K is "MAPK-Pase_P-Erk2"; - rel_K_PP_max is "relative maximal K_PP"; - r1a is "binding of MAPKKK activator"; - r1b is "MAPKKK activation"; - r2a is "binding of MAPKKK inactivator"; - r2b is "MAPKKK inactivation"; - r3a is "binding P-MAPKKK and MAPKK"; - r3b is "phosphorylation of MAPKK"; - r4a is "binding MAPKK-Pase and P-MAPKK"; - r4b is "dephosphorylation of P-MAPKK"; - r5a is "binding P-MAPKKK and P-MAPKK"; - r5b is "phosphorylation of P-MAPKK"; - r6a is "binding MAPKK-Pase and PP-MAPKK"; - r6b is "dephosphorylation of PP-MAPKK"; - r7a is "binding MAPK and PP-MAPKK"; - r7b is "phosphorylation of MAPK"; - r8a is "binding MAPK-Pase and P-MAPK"; - r8b is "dephosphorylation of P-MAPK"; - r9a is "binding PP-MAPKK and P-MAPK"; - r9b is "phosphorylation of P-MAPK"; - r10a is "binding MAPK-Pase and PP-MAPK"; - r10b is "dephosphorylation of PP-MAPK"; - - // CV terms: - E1 hypernym "http://identifiers.org/interpro/IPR003577" - KKK hypernym "http://identifiers.org/uniprot/P12965" - P_KKK hypernym "http://identifiers.org/uniprot/P12965" - KK hypernym "http://identifiers.org/uniprot/Q05116" - P_KK hypernym "http://identifiers.org/uniprot/Q05116" - PP_KK hypernym "http://identifiers.org/uniprot/Q05116" - K hypernym "http://identifiers.org/uniprot/P26696" - P_K hypernym "http://identifiers.org/uniprot/P26696" - PP_K hypernym "http://identifiers.org/uniprot/P26696" - KPase identity "http://identifiers.org/uniprot/Q90W58" - E1_KKK part "http://identifiers.org/uniprot/P12965", - "http://identifiers.org/interpro/IPR003577" - E2_P_KKK part "http://identifiers.org/uniprot/P12965" - P_KKK_KK part "http://identifiers.org/uniprot/P12965", - "http://identifiers.org/uniprot/Q05116" - P_KKK_P_KK part "http://identifiers.org/uniprot/P12965", - "http://identifiers.org/uniprot/Q05116" - PP_KK_K part "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - PP_KK_P_K part "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - KKPase_PP_KK part "http://identifiers.org/uniprot/Q05116" - KKPase_P_KK part "http://identifiers.org/uniprot/Q05116" - KPase_PP_K part "http://identifiers.org/uniprot/Q90W58", - "http://identifiers.org/uniprot/P26696" - KPase_P_K part "http://identifiers.org/uniprot/P26696", - "http://identifiers.org/uniprot/Q90W58" - r1a homolog "http://identifiers.org/reactome/REACT_996" - r1a hypernym "http://identifiers.org/go/GO:0031435" - r1b homolog "http://identifiers.org/reactome/REACT_525" - r1b hypernym "http://identifiers.org/ec-code/2.7.11.1", - "http://identifiers.org/go/GO:0008349", - "http://identifiers.org/go/GO:0000185" - r2a hypernym "http://identifiers.org/go/GO:0031435" - r2b hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0051390", - "http://identifiers.org/go/GO:0006470" - r3a homolog "http://identifiers.org/reactome/REACT_143" - r3a hypernym "http://identifiers.org/go/GO:0031434", - "http://identifiers.org/go/GO:0031435" - r3b homolog "http://identifiers.org/reactome/REACT_614" - r3b hypernym "http://identifiers.org/ec-code/2.7.11.25", - "http://identifiers.org/go/GO:0006468", - "http://identifiers.org/go/GO:0004709" - r4a hypernym "http://identifiers.org/go/GO:0031434" - r4b hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0006470" - r5a homolog "http://identifiers.org/reactome/REACT_143" - r5a hypernym "http://identifiers.org/go/GO:0031435", - "http://identifiers.org/go/GO:0031434" - r5b homolog "http://identifiers.org/reactome/REACT_614" - r5b hypernym "http://identifiers.org/ec-code/2.7.11.25", - "http://identifiers.org/go/GO:0006468", - "http://identifiers.org/go/GO:0004709", - "http://identifiers.org/go/GO:0000186" - r6a hypernym "http://identifiers.org/go/GO:0031434" - r6b hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0006470", - "http://identifiers.org/go/GO:0051389" - r7a version "http://identifiers.org/reactome/REACT_1780", - "http://identifiers.org/reactome/REACT_495" - r7a hypernym "http://identifiers.org/go/GO:0031434", - "http://identifiers.org/go/GO:0051019" - r7b version "http://identifiers.org/reactome/REACT_136", - "http://identifiers.org/reactome/REACT_2247" - r7b hypernym "http://identifiers.org/ec-code/2.7.12.2", - "http://identifiers.org/go/GO:0006468", - "http://identifiers.org/go/GO:0004708" - r8a hypernym "http://identifiers.org/go/GO:0051019" - r8b hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0006470" - r9a version "http://identifiers.org/reactome/REACT_1780", - "http://identifiers.org/reactome/REACT_495" - r9a hypernym "http://identifiers.org/go/GO:0051019", - "http://identifiers.org/go/GO:0031434" - r9b hypernym "http://identifiers.org/ec-code/2.7.12.2", - "http://identifiers.org/go/GO:0006468", - "http://identifiers.org/go/GO:0004708", - "http://identifiers.org/go/GO:0000187" - r9b version "http://identifiers.org/reactome/REACT_136", - "http://identifiers.org/reactome/REACT_2247" - r10a hypernym "http://identifiers.org/go/GO:0051019" - r10b hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0006470", - "http://identifiers.org/go/GO:0000188" -end - -BIOMD0000000009 is "Huang1996 - Ultrasensitivity in MAPK cascade" - -BIOMD0000000009 model_entity_is "http://identifiers.org/biomodels.db/MODEL6615048798" -BIOMD0000000009 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000009" -BIOMD0000000009 description "http://identifiers.org/pubmed/8816754" -BIOMD0000000009 homolog "http://identifiers.org/reactome/REACT_634" -BIOMD0000000009 hypernym "http://identifiers.org/go/GO:0000165" -BIOMD0000000009 taxon "http://identifiers.org/taxonomy/8355" diff --git a/BioModelsRAG/data/BIOMD0000000010.txt b/BioModelsRAG/data/BIOMD0000000010.txt deleted file mode 100644 index f0f5bc9197738de17664c6570d17e07feed098fd..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000010.txt +++ /dev/null @@ -1,140 +0,0 @@ -// Created by libAntimony v2.13.0 -model *BIOMD0000000010() - - // Compartments and Species: - compartment uVol; - species MKKK in uVol, MKKK_P in uVol, MKK in uVol, MKK_P in uVol, MKK_PP in uVol; - species MAPK in uVol, MAPK_P in uVol, MAPK_PP in uVol; - - // Reactions: - J0: MKKK => MKKK_P; uVol*J0_V1*MKKK/((1 + (MAPK_PP/J0_Ki)^J0_n)*(J0_K1 + MKKK)); - J1: MKKK_P => MKKK; uVol*J1_V2*MKKK_P/(J1_KK2 + MKKK_P); - J2: MKK => MKK_P; uVol*J2_k3*MKKK_P*MKK/(J2_KK3 + MKK); - J3: MKK_P => MKK_PP; uVol*J3_k4*MKKK_P*MKK_P/(J3_KK4 + MKK_P); - J4: MKK_PP => MKK_P; uVol*J4_V5*MKK_PP/(J4_KK5 + MKK_PP); - J5: MKK_P => MKK; uVol*J5_V6*MKK_P/(J5_KK6 + MKK_P); - J6: MAPK => MAPK_P; uVol*J6_k7*MKK_PP*MAPK/(J6_KK7 + MAPK); - J7: MAPK_P => MAPK_PP; uVol*J7_k8*MKK_PP*MAPK_P/(J7_KK8 + MAPK_P); - J8: MAPK_PP => MAPK_P; uVol*J8_V9*MAPK_PP/(J8_KK9 + MAPK_PP); - J9: MAPK_P => MAPK; uVol*J9_V10*MAPK_P/(J9_KK10 + MAPK_P); - - // Species initializations: - MKKK = 90; - MKKK_P = 10; - MKK = 280; - MKK_P = 10; - MKK_PP = 10; - MAPK = 280; - MAPK_P = 10; - MAPK_PP = 10; - - // Compartment initializations: - uVol = 1; - - // Variable initializations: - J0_V1 = 2.5; - J0_Ki = 9; - J0_n = 1; - J0_K1 = 10; - J1_V2 = 0.25; - J1_KK2 = 8; - J2_k3 = 0.025; - J2_KK3 = 15; - J3_k4 = 0.025; - J3_KK4 = 15; - J4_V5 = 0.75; - J4_KK5 = 15; - J5_V6 = 0.75; - J5_KK6 = 15; - J6_k7 = 0.025; - J6_KK7 = 15; - J7_k8 = 0.025; - J7_KK8 = 15; - J8_V9 = 0.5; - J8_KK9 = 15; - J9_V10 = 0.5; - J9_KK10 = 15; - - // Other declarations: - const uVol; - - // Unit definitions: - unit substance = 1e-9 mole; - - // Display Names: - substance is "nanomole"; - MKKK is "Mos"; - MKKK_P is "Mos-P"; - MKK is "Mek1"; - MKK_P is "Mek1-P"; - MKK_PP is "Mek1-PP"; - MAPK is "Erk2"; - MAPK_P is "Erk2-P"; - MAPK_PP is "Erk2-PP"; - J0 is "MAPKKK activation"; - J1 is "MAPKKK inactivation"; - J2 is "phosphorylation of MAPKK"; - J3 is "phosphorylation of MAPKK-P"; - J4 is "dephosphorylation of MAPKK-PP"; - J5 is "dephosphorylation of MAPKK-P"; - J6 is "phosphorylation of MAPK"; - J7 is "phosphorylation of MAPK-P"; - J8 is "dephosphorylation of MAPK-PP"; - J9 is "dephosphorylation of MAPK-P"; - - // CV terms: - MKKK hypernym "http://identifiers.org/uniprot/P09560" - MKKK_P hypernym "http://identifiers.org/uniprot/P09560" - MKK hypernym "http://identifiers.org/uniprot/Q05116" - MKK_P hypernym "http://identifiers.org/uniprot/Q05116" - MKK_PP hypernym "http://identifiers.org/uniprot/Q05116" - MAPK hypernym "http://identifiers.org/uniprot/P26696" - MAPK_P hypernym "http://identifiers.org/uniprot/P26696" - MAPK_PP hypernym "http://identifiers.org/uniprot/P26696" - J0 homolog "http://identifiers.org/reactome/REACT_525" - J0 hypernym "http://identifiers.org/ec-code/2.7.11.1", - "http://identifiers.org/go/GO:0000185", - "http://identifiers.org/go/GO:0008349" - J1 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0051390", - "http://identifiers.org/go/GO:0006470" - J2 homolog "http://identifiers.org/reactome/REACT_614" - J2 hypernym "http://identifiers.org/ec-code/2.7.11.25", - "http://identifiers.org/go/GO:0004709", - "http://identifiers.org/go/GO:0006468" - J3 homolog "http://identifiers.org/reactome/REACT_614" - J3 hypernym "http://identifiers.org/ec-code/2.7.11.25", - "http://identifiers.org/go/GO:0000186", - "http://identifiers.org/go/GO:0006468", - "http://identifiers.org/go/GO:0004709" - J4 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0006470", - "http://identifiers.org/go/GO:0051389" - J5 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0006470" - J6 version "http://identifiers.org/reactome/REACT_136", - "http://identifiers.org/reactome/REACT_2247" - J6 hypernym "http://identifiers.org/ec-code/2.7.12.2", - "http://identifiers.org/go/GO:0004708", - "http://identifiers.org/go/GO:0006468" - J7 version "http://identifiers.org/reactome/REACT_136", - "http://identifiers.org/reactome/REACT_2247" - J7 hypernym "http://identifiers.org/ec-code/2.7.12.2", - "http://identifiers.org/go/GO:0006468", - "http://identifiers.org/go/GO:0004708", - "http://identifiers.org/go/GO:0000187" - J8 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0000188", - "http://identifiers.org/go/GO:0006470" - J9 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0006470" -end - -BIOMD0000000010 is "Kholodenko2000 - Ultrasensitivity and negative feedback bring oscillations in MAPK cascade" - -BIOMD0000000010 model_entity_is "http://identifiers.org/biomodels.db/MODEL6615119181" -BIOMD0000000010 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000010" -BIOMD0000000010 description "http://identifiers.org/pubmed/10712587" -BIOMD0000000010 hypernym "http://identifiers.org/go/GO:0000165" -BIOMD0000000010 homolog "http://identifiers.org/reactome/REACT_634" -BIOMD0000000010 taxon "http://identifiers.org/taxonomy/8355" diff --git a/BioModelsRAG/data/BIOMD0000000011.txt b/BioModelsRAG/data/BIOMD0000000011.txt deleted file mode 100644 index b11b2a260f9b44c2dce717b1ecffd22f2601b090..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000011.txt +++ /dev/null @@ -1,272 +0,0 @@ -// Created by libAntimony v2.13.0 -model *MAPK_in_Solution() - - // Compartments and Species: - compartment Cytoplasm; - substanceOnly species MAPK in Cytoplasm, MAPKMEKpp in Cytoplasm, MAPKp in Cytoplasm; - substanceOnly species MAPKPH in Cytoplasm, MAPKpMAPKPH in Cytoplasm, MAPKpMEKpp in Cytoplasm; - substanceOnly species MAPKpp in Cytoplasm, MAPKppMAPKPH in Cytoplasm, MEK in Cytoplasm; - substanceOnly species MEKp in Cytoplasm, MEKPH in Cytoplasm, MEKpMEKPH in Cytoplasm; - substanceOnly species MEKpp in Cytoplasm, MEKppMEKPH in Cytoplasm, MEKpRAFp in Cytoplasm; - substanceOnly species MEKRAFp in Cytoplasm, RAF in Cytoplasm, RAFK in Cytoplasm; - substanceOnly species RAFp in Cytoplasm, RAFPH in Cytoplasm, RAFpRAFPH in Cytoplasm; - substanceOnly species RAFRAFK in Cytoplasm; - - // Reactions: - Reaction1: RAF + RAFK => RAFRAFK; Reaction1_a1*RAF*RAFK; - Reaction2: RAFRAFK => RAF + RAFK; Reaction2_d1*RAFRAFK; - Reaction3: RAFRAFK => RAFK + RAFp; Reaction3_k1*RAFRAFK; - Reaction4: RAFp + RAFPH => RAFpRAFPH; Reaction4_a2*RAFp*RAFPH; - Reaction5: RAFpRAFPH => RAFp + RAFPH; Reaction5_d2*RAFpRAFPH; - Reaction6: RAFpRAFPH => RAF + RAFPH; Reaction6_k2*RAFpRAFPH; - Reaction7: MEK + RAFp => MEKRAFp; Reaction7_a3*MEK*RAFp; - Reaction8: MEKRAFp => MEK + RAFp; Reaction8_d3*MEKRAFp; - Reaction9: MEKRAFp => MEKp + RAFp; Reaction9_k3*MEKRAFp; - Reaction10: MEKp + MEKPH => MEKpMEKPH; Reaction10_a4*MEKp*MEKPH; - Reaction11: MEKpMEKPH => MEKp + MEKPH; Reaction11_d4*MEKpMEKPH; - Reaction12: MEKpMEKPH => MEK + MEKPH; Reaction12_k4*MEKpMEKPH; - Reaction13: MEKp + RAFp => MEKpRAFp; Reaction13_a5*MEKp*RAFp; - Reaction14: MEKpRAFp => MEKp + RAFp; Reaction14_d5*MEKpRAFp; - Reaction15: MEKpRAFp => MEKpp + RAFp; Reaction15_k5*MEKpRAFp; - Reaction16: MEKPH + MEKpp => MEKppMEKPH; Reaction16_a6*MEKPH*MEKpp; - Reaction17: MEKppMEKPH => MEKPH + MEKpp; Reaction17_d6*MEKppMEKPH; - Reaction18: MEKppMEKPH => MEKp + MEKPH; Reaction18_k6*MEKppMEKPH; - Reaction19: MAPK + MEKpp => MAPKMEKpp; Reaction19_a7*MAPK*MEKpp; - Reaction20: MAPKMEKpp => MAPK + MEKpp; Reaction20_d7*MAPKMEKpp; - Reaction21: MAPKMEKpp => MAPKp + MEKpp; Reaction21_k7*MAPKMEKpp; - Reaction22: MAPKp + MAPKPH => MAPKpMAPKPH; Reaction22_a8*MAPKp*MAPKPH; - Reaction23: MAPKpMAPKPH => MAPKp + MAPKPH; Reaction23_d8*MAPKpMAPKPH; - Reaction24: MAPKpMAPKPH => MAPK + MAPKPH; Reaction24_k8*MAPKpMAPKPH; - Reaction25: MAPKp + MEKpp => MAPKpMEKpp; Reaction25_a9*MAPKp*MEKpp; - Reaction26: MAPKpMEKpp => MAPKp + MEKpp; Reaction26_d9*MAPKpMEKpp; - Reaction27: MAPKpMEKpp => MAPKpp + MEKpp; Reaction27_k9*MAPKpMEKpp; - Reaction28: MAPKPH + MAPKpp => MAPKppMAPKPH; Reaction28_a10*MAPKPH*MAPKpp; - Reaction29: MAPKppMAPKPH => MAPKPH + MAPKpp; Reaction29_d10*MAPKppMAPKPH; - Reaction30: MAPKppMAPKPH => MAPKp + MAPKPH; Reaction30_k10*MAPKppMAPKPH; - - // Species initializations: - MAPK = 0.4/Cytoplasm; - MAPKMEKpp = 0; - MAPKp = 0; - MAPKPH = 0.3/Cytoplasm; - MAPKpMAPKPH = 0; - MAPKpMEKpp = 0; - MAPKpp = 0; - MAPKppMAPKPH = 0; - MEK = 0.2/Cytoplasm; - MEKp = 0; - MEKPH = 0.2/Cytoplasm; - MEKpMEKPH = 0; - MEKpp = 0; - MEKppMEKPH = 0; - MEKpRAFp = 0; - MEKRAFp = 0; - RAF = 0.3/Cytoplasm; - RAFK = 0.2/Cytoplasm; - RAFp = 0; - RAFPH = 0.3/Cytoplasm; - RAFpRAFPH = 0; - RAFRAFK = 0; - - // Compartment initializations: - Cytoplasm = 1; - - // Variable initializations: - Reaction1_a1 = 1; - Reaction2_d1 = 0.4; - Reaction3_k1 = 0.1; - Reaction4_a2 = 0.5; - Reaction5_d2 = 0.5; - Reaction6_k2 = 0.1; - Reaction7_a3 = 3.3; - Reaction8_d3 = 0.42; - Reaction9_k3 = 0.1; - Reaction10_a4 = 10; - Reaction11_d4 = 0.8; - Reaction12_k4 = 0.1; - Reaction13_a5 = 3.3; - Reaction14_d5 = 0.4; - Reaction15_k5 = 0.1; - Reaction16_a6 = 10; - Reaction17_d6 = 0.8; - Reaction18_k6 = 0.1; - Reaction19_a7 = 20; - Reaction20_d7 = 0.6; - Reaction21_k7 = 0.1; - Reaction22_a8 = 5; - Reaction23_d8 = 0.4; - Reaction24_k8 = 0.1; - Reaction25_a9 = 20; - Reaction26_d9 = 0.6; - Reaction27_k9 = 0.1; - Reaction28_a10 = 5; - Reaction29_d10 = 0.4; - Reaction30_k10 = 0.1; - - // Other declarations: - const Cytoplasm; - - // Unit definitions: - unit substance = 1e-6 mole; - - // Display Names: - substance is "micromole"; - MAPKMEKpp is "MAPK_MEK-PP"; - MAPKp is "MAPK-P"; - MAPKPH is "MAPK phosphatase"; - MAPKpMAPKPH is "MAPK-P_MAPKPase"; - MAPKpMEKpp is "MAPK-P_MEK-PP"; - MAPKpp is "MAPK-PP"; - MAPKppMAPKPH is "MAPK-PP_MAPKPase"; - MEKp is "MEK-P"; - MEKPH is "MEK phosphatase"; - MEKpMEKPH is "MEK-P_MEKPase"; - MEKpp is "MEK-PP"; - MEKppMEKPH is "MEK-PP_MEKPase"; - MEKpRAFp is "MEK-P_RAF-P"; - MEKRAFp is "MEK_RAF-P"; - RAFp is "RAF-P"; - RAFPH is "RAF phosphatase"; - RAFpRAFPH is "RAF-P_RAFPase"; - RAFRAFK is "RAF_RAFK"; - Reaction1 is "binding of RAF and RAFK"; - Reaction2 is "dissociation of RAF_RAFK"; - Reaction3 is "phosphorylation of RAF"; - Reaction4 is "binding of RAF-P and RAF phosphatase"; - Reaction5 is "dissociation of RAF-P_RAFPase"; - Reaction6 is "dephosphorylation of RAF-P"; - Reaction7 is "binding of MEK and RAF-P"; - Reaction8 is "dissociation of MEK_RAF-P"; - Reaction9 is "phosphorylation of MEK"; - Reaction10 is "binding of MEK-P and MEK phosphatase"; - Reaction11 is "dissociation of MEK-P_MEKPase"; - Reaction12 is "dephosphorylation of MEK-P"; - Reaction13 is "binding of MEK-P and RAF-P"; - Reaction14 is "dissociation of MEK-P_RAF-P"; - Reaction15 is "phosphorylation of MEK-P"; - Reaction16 is "binding of MEK-PP and MEK phosphatase"; - Reaction17 is "dissociation of MEK-PP_MEKPase"; - Reaction18 is "dephosphorylation of MEK-PP"; - Reaction19 is "binding of MAPK and MEK-PP"; - Reaction20 is "dissociation of MAPK_MEK-PP"; - Reaction21 is "phosphorylation of MAPK"; - Reaction22 is "binding of MAPK-P and MAPK phosphatase"; - Reaction23 is "dissociation of MAPK-P_MAPKPase"; - Reaction24 is "dephosphorylation of MAPK-P"; - Reaction25 is "binding of MAPK-P and MEK-PP"; - Reaction26 is "dissociation of MAPK-P_MEK-PP"; - Reaction27 is "phosphorylation of MAPK-P"; - Reaction28 is "binding of MAPK-PP and MAPK phosphatase"; - Reaction29 is "dissociation of MAPK-PP_MAPKPase"; - Reaction30 is "dephosphorylation of MAPK-PP"; - - // CV terms: - Cytoplasm identity "http://identifiers.org/obo.go/GO:0005737" - MAPK hypernym "http://identifiers.org/uniprot/P26696" - MAPKMEKpp part "http://identifiers.org/uniprot/P26696", - "http://identifiers.org/uniprot/Q05116" - MAPKp hypernym "http://identifiers.org/uniprot/P26696" - MAPKPH identity "http://identifiers.org/uniprot/Q90W58" - MAPKpMAPKPH part "http://identifiers.org/uniprot/P26696", - "http://identifiers.org/uniprot/Q90W58" - MAPKpMEKpp part "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - MAPKpp hypernym "http://identifiers.org/uniprot/P26696" - MAPKppMAPKPH part "http://identifiers.org/uniprot/P26696", - "http://identifiers.org/uniprot/Q90W58" - MEK hypernym "http://identifiers.org/uniprot/Q05116" - MEKp hypernym "http://identifiers.org/uniprot/Q05116" - MEKpMEKPH part "http://identifiers.org/uniprot/Q05116" - MEKpp hypernym "http://identifiers.org/uniprot/Q05116" - MEKppMEKPH part "http://identifiers.org/uniprot/Q05116" - MEKpRAFp part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116" - MEKRAFp part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116" - RAF hypernym "http://identifiers.org/uniprot/P09560" - RAFK hypernym "http://identifiers.org/interpro/IPR003577" - RAFp hypernym "http://identifiers.org/uniprot/P09560" - RAFpRAFPH part "http://identifiers.org/uniprot/P09560" - RAFRAFK part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/interpro/IPR003577" - Reaction1 homolog "http://identifiers.org/reactome/REACT_996" - Reaction1 hypernym "http://identifiers.org/obo.go/GO:0031435" - Reaction2 hypernym "http://identifiers.org/obo.go/GO:0043241" - Reaction3 hypernym "http://identifiers.org/ec-code/2.7.11.1", - "http://identifiers.org/obo.go/GO:0008349", - "http://identifiers.org/obo.go/GO:0000185", - "http://identifiers.org/obo.go/GO:0006468" - Reaction4 hypernym "http://identifiers.org/obo.go/GO:0031435" - Reaction5 hypernym "http://identifiers.org/obo.go/GO:0043241" - Reaction6 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/obo.go/GO:0051390", - "http://identifiers.org/obo.go/GO:0006470" - Reaction7 homolog "http://identifiers.org/reactome/REACT_143" - Reaction7 hypernym "http://identifiers.org/obo.go/GO:0031434", - "http://identifiers.org/obo.go/GO:0031435" - Reaction8 hypernym "http://identifiers.org/obo.go/GO:0043241" - Reaction9 homolog "http://identifiers.org/reactome/REACT_614" - Reaction9 hypernym "http://identifiers.org/ec-code/2.7.11.25", - "http://identifiers.org/obo.go/GO:0004709", - "http://identifiers.org/obo.go/GO:0006468" - Reaction10 hypernym "http://identifiers.org/obo.go/GO:0031434" - Reaction11 hypernym "http://identifiers.org/obo.go/GO:0043241" - Reaction12 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/obo.go/GO:0006470" - Reaction13 homolog "http://identifiers.org/reactome/REACT_143" - Reaction13 hypernym "http://identifiers.org/obo.go/GO:0031435", - "http://identifiers.org/obo.go/GO:0031434" - Reaction14 hypernym "http://identifiers.org/obo.go/GO:0043241" - Reaction15 homolog "http://identifiers.org/reactome/REACT_614" - Reaction15 hypernym "http://identifiers.org/ec-code/2.7.11.25", - "http://identifiers.org/obo.go/GO:0006468", - "http://identifiers.org/obo.go/GO:0004709", - "http://identifiers.org/obo.go/GO:0000186" - Reaction16 hypernym "http://identifiers.org/obo.go/GO:0031434" - Reaction17 hypernym "http://identifiers.org/obo.go/GO:0043241" - Reaction18 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/obo.go/GO:0051389", - "http://identifiers.org/obo.go/GO:0006470" - Reaction19 homolog "http://identifiers.org/reactome/REACT_495", - "http://identifiers.org/reactome/REACT_1780" - Reaction19 identity "http://identifiers.org/obo.go/GO:0051019", - "http://identifiers.org/obo.go/GO:0031434" - Reaction20 hypernym "http://identifiers.org/obo.go/GO:0043241" - Reaction21 homolog "http://identifiers.org/reactome/REACT_2247", - "http://identifiers.org/reactome/REACT_136" - Reaction21 hypernym "http://identifiers.org/ec-code/2.7.12.2", - "http://identifiers.org/obo.go/GO:0006468", - "http://identifiers.org/obo.go/GO:0004708" - Reaction22 hypernym "http://identifiers.org/obo.go/GO:0051019" - Reaction23 hypernym "http://identifiers.org/obo.go/GO:0043241" - Reaction24 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/obo.go/GO:0006470" - Reaction25 homolog "http://identifiers.org/reactome/REACT_495", - "http://identifiers.org/reactome/REACT_1780" - Reaction25 hypernym "http://identifiers.org/obo.go/GO:0051019", - "http://identifiers.org/obo.go/GO:0031434" - Reaction26 hypernym "http://identifiers.org/obo.go/GO:0043241" - Reaction27 hypernym "http://identifiers.org/ec-code/2.7.12.2", - "http://identifiers.org/obo.go/GO:0000187", - "http://identifiers.org/obo.go/GO:0006468", - "http://identifiers.org/obo.go/GO:0004708" - Reaction27 homolog "http://identifiers.org/reactome/REACT_136", - "http://identifiers.org/reactome/REACT_2247" - Reaction28 hypernym "http://identifiers.org/obo.go/GO:0051019" - Reaction29 hypernym "http://identifiers.org/obo.go/GO:0043241" - Reaction30 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/obo.go/GO:0006470", - "http://identifiers.org/obo.go/GO:0000188" -end - -MAPK_in_Solution is "Levchenko2000_MAPK_noScaffold" - -MAPK_in_Solution model_entity_is "http://identifiers.org/biomodels.db/MODEL6615234250" -MAPK_in_Solution model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000011" -MAPK_in_Solution description "http://identifiers.org/pubmed/10823939" -MAPK_in_Solution origin "http://identifiers.org/biomodels.db/BIOMD0000000009", - "http://identifiers.org/pubmed/6501300", - "http://identifiers.org/pubmed/6947258" -MAPK_in_Solution homolog "http://identifiers.org/reactome/REACT_634" -MAPK_in_Solution hypernym "http://identifiers.org/obo.go/GO:0000165" -MAPK_in_Solution taxon "http://identifiers.org/taxonomy/8355" diff --git a/BioModelsRAG/data/BIOMD0000000012.txt b/BioModelsRAG/data/BIOMD0000000012.txt deleted file mode 100644 index 985a9d8b9c8d0c7b5514d47422df2bc5b3f8e634..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000012.txt +++ /dev/null @@ -1,161 +0,0 @@ -// Created by libAntimony v2.13.0 -model *BIOMD0000000012() - - // Compartments and Species: - compartment cell; - substanceOnly species PX in cell, PY in cell, PZ in cell, X in cell, Y in cell; - substanceOnly species Z in cell; - - // Assignment Rules: - beta := tau_mRNA/tau_prot; - alpha0 := a0_tr*eff*tau_prot/(ln(2)*KM); - a0_tr := ps_0*60; - alpha := a_tr*eff*tau_prot/(ln(2)*KM); - a_tr := (ps_a - ps_0)*60; - t_ave := tau_mRNA/ln(2); - kd_mRNA := ln(2)/tau_mRNA; - kd_prot := ln(2)/tau_prot; - k_tl := eff/t_ave; - - // Reactions: - Reaction1: X => ; kd_mRNA*X; - Reaction2: Y => ; kd_mRNA*Y; - Reaction3: Z => ; kd_mRNA*Z; - Reaction4: => PX; k_tl*X; - Reaction5: => PY; k_tl*Y; - Reaction6: => PZ; k_tl*Z; - Reaction7: PX => ; kd_prot*PX; - Reaction8: PY => ; kd_prot*PY; - Reaction9: PZ => ; kd_prot*PZ; - Reaction10: => X; a0_tr + a_tr*KM^n/(KM^n + PZ^n); - Reaction11: => Y; a0_tr + a_tr*KM^n/(KM^n + PX^n); - Reaction12: => Z; a0_tr + a_tr*KM^n/(KM^n + PY^n); - - // Species initializations: - PX = 0; - PY = 0; - PZ = 0; - X = 0; - Y = 20/cell; - Z = 0; - - // Compartment initializations: - cell = 1; - - // Variable initializations: - tau_mRNA = 2; - tau_prot = 10; - eff = 20; - KM = 40; - n = 2; - ps_a = 0.5; - ps_0 = 0.0005; - - // Other declarations: - var beta, alpha0, a0_tr, alpha, a_tr, t_ave, kd_mRNA, kd_prot, k_tl; - const cell, tau_mRNA, tau_prot, eff, KM, n, ps_a, ps_0; - - // Unit definitions: - unit volume = 1e-15 litre; - unit substance = item; - unit time_unit = 60 second; - - // Display Names: - volume is "cubic microns"; - substance is "item"; - time_unit is "minute"; - PX is "LacI protein"; - PY is "TetR protein"; - PZ is "cI protein"; - X is "LacI mRNA"; - Y is "TetR mRNA"; - Z is "cI mRNA"; - tau_mRNA is "mRNA half life"; - tau_prot is "protein half life"; - eff is "translation efficiency"; - t_ave is "average mRNA life time"; - ps_a is "tps_active"; - ps_0 is "tps_repr"; - Reaction1 is "degradation of LacI transcripts"; - Reaction2 is "degradation of TetR transcripts"; - Reaction3 is "degradation of CI transcripts"; - Reaction4 is "translation of LacI"; - Reaction5 is "translation of TetR"; - Reaction6 is "translation of CI"; - Reaction7 is "degradation of LacI"; - Reaction8 is "degradation of TetR"; - Reaction9 is "degradation of CI"; - Reaction10 is "transcription of LacI"; - Reaction11 is "transcription of TetR"; - Reaction12 is "transcription of CI"; - - // SBO terms: - cell.sboTerm = 290 - PX.sboTerm = 252 - PY.sboTerm = 252 - PZ.sboTerm = 252 - X.sboTerm = 250 - Y.sboTerm = 250 - Z.sboTerm = 250 - tau_mRNA.sboTerm = 332 - tau_prot.sboTerm = 332 - alpha0.sboTerm = 485 - a0_tr.sboTerm = 485 - KM.sboTerm = 288 - alpha.sboTerm = 186 - a_tr.sboTerm = 186 - n.sboTerm = 190 - t_ave.sboTerm = 348 - kd_mRNA.sboTerm = 356 - kd_prot.sboTerm = 356 - k_tl.sboTerm = 16 - ps_a.sboTerm = 186 - ps_0.sboTerm = 485 - Reaction1.sboTerm = 179 - Reaction2.sboTerm = 179 - Reaction3.sboTerm = 179 - Reaction4.sboTerm = 184 - Reaction5.sboTerm = 184 - Reaction6.sboTerm = 184 - Reaction7.sboTerm = 179 - Reaction8.sboTerm = 179 - Reaction9.sboTerm = 179 - Reaction10.sboTerm = 183 - Reaction11.sboTerm = 183 - Reaction12.sboTerm = 183 - - // CV terms: - cell identity "http://identifiers.org/obo.go/GO:0005623" - PX identity "http://identifiers.org/uniprot/P03023" - PY identity "http://identifiers.org/uniprot/P04483" - PZ identity "http://identifiers.org/uniprot/P03034" - X hypernym "http://identifiers.org/chebi/CHEBI:33699", - "http://identifiers.org/kegg.compound/C00046" - X encodement "http://identifiers.org/uniprot/P03023" - Y hypernym "http://identifiers.org/chebi/CHEBI:33699", - "http://identifiers.org/kegg.compound/C00046" - Y encodement "http://identifiers.org/uniprot/P04483" - Z hypernym "http://identifiers.org/chebi/CHEBI:33699", - "http://identifiers.org/kegg.compound/C00046" - Z encodement "http://identifiers.org/uniprot/P03034" - Reaction1 hypernym "http://identifiers.org/obo.go/GO:0006402" - Reaction2 hypernym "http://identifiers.org/obo.go/GO:0006402" - Reaction3 hypernym "http://identifiers.org/obo.go/GO:0006402" - Reaction4 hypernym "http://identifiers.org/obo.go/GO:0006412" - Reaction5 hypernym "http://identifiers.org/obo.go/GO:0006412" - Reaction6 hypernym "http://identifiers.org/obo.go/GO:0006412" - Reaction7 hypernym "http://identifiers.org/obo.go/GO:0030163" - Reaction8 hypernym "http://identifiers.org/obo.go/GO:0030163" - Reaction9 hypernym "http://identifiers.org/obo.go/GO:0030163" - Reaction10 hypernym "http://identifiers.org/obo.go/GO:0006351" - Reaction11 hypernym "http://identifiers.org/obo.go/GO:0006351" - Reaction12 hypernym "http://identifiers.org/obo.go/GO:0006351" -end - -BIOMD0000000012 is "Elowitz2000 - Repressilator" - -BIOMD0000000012 model_entity_is "http://identifiers.org/biomodels.db/MODEL6615351360" -BIOMD0000000012 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000012" -BIOMD0000000012 description "http://identifiers.org/pubmed/10659856" -BIOMD0000000012 taxon "http://identifiers.org/taxonomy/562" -BIOMD0000000012 hypernym "http://identifiers.org/obo.go/GO:0040029" diff --git a/BioModelsRAG/data/BIOMD0000000013.txt b/BioModelsRAG/data/BIOMD0000000013.txt deleted file mode 100644 index aa0b5329c530fd283e752a287e406d949769143a..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000013.txt +++ /dev/null @@ -1,264 +0,0 @@ -// Created by libAntimony v2.13.0 -model *untitled() - - // Compartments and Species: - compartment chloroplast, cytosol; - species $x_CO2 in chloroplast, RuBP_ch in chloroplast, PGA_ch in chloroplast; - species ATP_ch in chloroplast, BPGA_ch in chloroplast, $x_NADPH_ch in chloroplast; - species GAP_ch in chloroplast, Pi_ch in chloroplast, DHAP_ch in chloroplast; - species FBP_ch in chloroplast, F6P_ch in chloroplast, E4P_ch in chloroplast; - species X5P_ch in chloroplast, SBP_ch in chloroplast, S7P_ch in chloroplast; - species R5P_ch in chloroplast, Ru5P_ch in chloroplast, $x_Pi_cyt in cytosol; - species $x_GAP_cyt in cytosol, G6P_ch in chloroplast, $x_NADP_ch in chloroplast; - species $x_PGA_cyt in cytosol, ADP_ch in chloroplast, $x_DHAP_cyt in cytosol; - species $x_Proton_ch in chloroplast, G1P_ch in chloroplast, $x_Starch_ch in chloroplast; - - // Reactions: - E1: RuBP_ch + $x_CO2 => 2 PGA_ch; Light_on*E1_Rbco_vm*RuBP_ch*chloroplast/(RuBP_ch + E1_Rbco_km*(1 + PGA_ch/E1_Rbco_KiPGA + FBP_ch/E1_Rbco_KiFBP + SBP_ch/E1_Rbco_KiSBP + Pi_ch/E1_Rbco_KiPi + x_NADPH_ch/E1_Rbco_KiNADPH)); - E2: PGA_ch + ATP_ch => BPGA_ch + ADP_ch; Light_on*E2_PGK_v*chloroplast*(PGA_ch*ATP_ch - BPGA_ch*ADP_ch/E2_q2); - E3: $x_NADPH_ch + BPGA_ch + $x_Proton_ch => $x_NADP_ch + GAP_ch + Pi_ch; Light_on*E3_G3Pdh_v*chloroplast*(BPGA_ch*x_NADPH_ch*x_Proton_ch - x_NADP_ch*GAP_ch*Pi_ch/E3_q3); - E4: GAP_ch -> DHAP_ch; chloroplast*E4_TPI_v*(GAP_ch - DHAP_ch/E4_q4); - E5: GAP_ch + DHAP_ch -> FBP_ch; E5_F_Aldo_v*chloroplast*(DHAP_ch*GAP_ch - FBP_ch/E5_q5); - E6: FBP_ch => F6P_ch + Pi_ch; Light_on*E6_FBPase_ch_vm*FBP_ch*chloroplast/(FBP_ch + E6_FBPase_ch_km*(1 + F6P_ch/E6_FBPase_ch_KiF6P + Pi_ch/E6_FBPase_ch_KiPi)); - E7: GAP_ch + F6P_ch -> X5P_ch + E4P_ch; chloroplast*E7_F_TKL_v*(F6P_ch*GAP_ch - E4P_ch*X5P_ch/E7_q7); - E8: DHAP_ch + E4P_ch -> SBP_ch; chloroplast*E8_E_Aldo_v*(E4P_ch*DHAP_ch - SBP_ch/E8_q8); - E9: SBP_ch => Pi_ch + S7P_ch; Light_on*E9_SBPase_ch_vm*SBP_ch*chloroplast/(SBP_ch + E9_SBPase_ch_km*(1 + Pi_ch/E9_SBPase_ch_KiPi)); - E10: S7P_ch + GAP_ch -> R5P_ch + X5P_ch; chloroplast*E10_G_TKL_v*(GAP_ch*S7P_ch - X5P_ch*R5P_ch/E10_q10); - E11: R5P_ch -> Ru5P_ch; E11_R5Piso_v*chloroplast*(R5P_ch - Ru5P_ch/E11_q11); - E12: X5P_ch -> Ru5P_ch; chloroplast*E12_X5Pepi_v*(X5P_ch - Ru5P_ch/E12_q12); - E13: Ru5P_ch + ATP_ch => RuBP_ch + ADP_ch; Light_on*E13_Ru5Pk_ch_vm*Ru5P_ch*chloroplast*ATP_ch/((Ru5P_ch + E13_Ru5Pk_ch_km1*(1 + PGA_ch/E13_Ru5Pk_ch_KiPGA + RuBP_ch/E13_Ru5Pk_ch_KiRuBP + Pi_ch/E13_Ru5Pk_ch_KiPi))*(ATP_ch*(1 + ADP_ch/E13_Ru5Pk_ch_KiADP1) + E13_Ru5Pk_ch_km2*(1 + ADP_ch/E13_Ru5Pk_ch_KiADP2))); - E14: F6P_ch -> G6P_ch; E14_PGI_v*chloroplast*(F6P_ch - G6P_ch/E14_q14); - E15: G6P_ch -> G1P_ch; E15_PGM_v*chloroplast*(G6P_ch - G1P_ch/E15_q15); - light_reaction: Pi_ch + ADP_ch => ATP_ch; Light_on*light_reaction_LR_vm*ADP_ch*Pi_ch*chloroplast/((ADP_ch + light_reaction_LR_kmADP)*(Pi_ch + light_reaction_LR_kmPi)); - E16: ATP_ch + G1P_ch => $x_Starch_ch + ADP_ch + 2 Pi_ch; E16_StSyn_vm*G1P_ch*ATP_ch*chloroplast/((G1P_ch + E16_stsyn_ch_km1)*(1 + ADP_ch/E16_stsyn_ch_Ki)*(ATP_ch + E16_stsyn_ch_km2) + E16_stsyn_ch_km2*Pi_ch/(E16_stsyn_ch_ka1*PGA_ch) + E16_stsyn_ch_ka2*F6P_ch + E16_stsyn_ch_ka3*FBP_ch); - E17: $x_Starch_ch + Pi_ch => G1P_ch; E17_StPase_Vm*Pi_ch*chloroplast/(Pi_ch + E17_StPase_km*(1 + G1P_ch/E17_StPase_kiG1P)); - E18_DHAP: $x_Pi_cyt + DHAP_ch => $x_DHAP_cyt + Pi_ch; E18_DHAP_TP_Piap_vm*DHAP_ch*chloroplast/(E18_DHAP_TP_Piap_kDHAP_ch*(1 + (1 + E18_DHAP_TP_Piap_kPi_cyt/x_Pi_cyt)*(Pi_ch/E18_DHAP_TP_Piap_kPi_ch + PGA_ch/E18_DHAP_TP_Piap_kPGA_ch + DHAP_ch/E18_DHAP_TP_Piap_kDHAP_ch + GAP_ch/E18_DHAP_TP_Piap_kGAP_ch))); - E18_PGA: $x_Pi_cyt + PGA_ch => $x_PGA_cyt + Pi_ch; E18_PGA_PGA_xpMult*E18_PGA_TP_Piap_vm*PGA_ch*chloroplast/(E18_PGA_TP_Piap_kPGA_ch*(1 + (1 + E18_PGA_TP_Piap_kPi_cyt/x_Pi_cyt)*(Pi_ch/E18_PGA_TP_Piap_kPi_ch + PGA_ch/E18_PGA_TP_Piap_kPGA_ch + DHAP_ch/E18_PGA_TP_Piap_kDHAP_ch + GAP_ch/E18_PGA_TP_Piap_kGAP_ch))); - E18_GAP: $x_Pi_cyt + GAP_ch => $x_GAP_cyt + Pi_ch; E18_GAP_TP_Piap_vm*GAP_ch*chloroplast/(E18_GAP_TP_Piap_kGAP_ch*(1 + (1 + E18_GAP_TP_Piap_kPi_cyt/x_Pi_cyt)*(Pi_ch/E18_GAP_TP_Piap_kPi_ch + PGA_ch/E18_GAP_TP_Piap_kPGA_ch + DHAP_ch/E18_GAP_TP_Piap_kDHAP_ch + GAP_ch/E18_GAP_TP_Piap_kGAP_ch))); - - // Species initializations: - x_CO2 = 1; - RuBP_ch = 0.33644; - PGA_ch = 3.35479; - ATP_ch = 0.49806; - BPGA_ch = 0.14825; - x_NADPH_ch = 0.21; - GAP_ch = 0.01334; - Pi_ch = 1.5662; - DHAP_ch = 0.29345; - FBP_ch = 0.02776; - F6P_ch = 1.36481; - E4P_ch = 0.41021; - X5P_ch = 0.00363; - SBP_ch = 1.56486; - S7P_ch = 0.00541; - R5P_ch = 0.00599; - Ru5P_ch = 0.00235; - x_Pi_cyt = 0.5; - x_GAP_cyt = 1; - G6P_ch = 3.1396; - x_NADP_ch = 0.29; - x_PGA_cyt = 1; - ADP_ch = 0.00149; - x_DHAP_cyt = 1; - x_Proton_ch = 2.512e-05; - G1P_ch = 0.18206; - x_Starch_ch = 1; - - // Compartment initializations: - chloroplast = 1; - cytosol = 1; - - // Variable initializations: - Light_on = 1; - E1_Rbco_vm = 340; - E1_Rbco_km = 0.02; - E1_Rbco_KiPGA = 0.84; - E1_Rbco_KiFBP = 0.04; - E1_Rbco_KiSBP = 0.075; - E1_Rbco_KiPi = 0.9; - E1_Rbco_KiNADPH = 0.07; - E2_PGK_v = 500000000; - E2_q2 = 0.00031; - E3_G3Pdh_v = 500000000; - E3_q3 = 16000000; - E4_TPI_v = 500000000; - E4_q4 = 22; - E5_F_Aldo_v = 500000000; - E5_q5 = 7.1; - E6_FBPase_ch_vm = 200; - E6_FBPase_ch_km = 0.03; - E6_FBPase_ch_KiF6P = 0.7; - E6_FBPase_ch_KiPi = 12; - E7_F_TKL_v = 500000000; - E7_q7 = 0.084; - E8_E_Aldo_v = 500000000; - E8_q8 = 13; - E9_SBPase_ch_vm = 40; - E9_SBPase_ch_km = 0.013; - E9_SBPase_ch_KiPi = 12; - E10_G_TKL_v = 500000000; - E10_q10 = 0.85; - E11_R5Piso_v = 500000000; - E11_q11 = 0.4; - E12_X5Pepi_v = 500000000; - E12_q12 = 0.67; - E13_Ru5Pk_ch_vm = 10000; - E13_Ru5Pk_ch_km1 = 0.05; - E13_Ru5Pk_ch_KiPGA = 2; - E13_Ru5Pk_ch_KiRuBP = 0.7; - E13_Ru5Pk_ch_KiPi = 4; - E13_Ru5Pk_ch_KiADP1 = 2.5; - E13_Ru5Pk_ch_km2 = 0.05; - E13_Ru5Pk_ch_KiADP2 = 0.4; - E14_PGI_v = 500000000; - E14_q14 = 2.3; - E15_PGM_v = 500000000; - E15_q15 = 0.058; - light_reaction_LR_vm = 3500; - light_reaction_LR_kmADP = 0.014; - light_reaction_LR_kmPi = 0.3; - E16_StSyn_vm = 40; - E16_stsyn_ch_km1 = 0.08; - E16_stsyn_ch_Ki = 10; - E16_stsyn_ch_km2 = 0.08; - E16_stsyn_ch_ka1 = 0.1; - E16_stsyn_ch_ka2 = 0.02; - E16_stsyn_ch_ka3 = 0.02; - E17_StPase_Vm = 40; - E17_StPase_km = 0.1; - E17_StPase_kiG1P = 0.05; - E18_DHAP_TP_Piap_vm = 250; - E18_DHAP_TP_Piap_kDHAP_ch = 0.077; - E18_DHAP_TP_Piap_kPi_cyt = 0.74; - E18_DHAP_TP_Piap_kPi_ch = 0.63; - E18_DHAP_TP_Piap_kPGA_ch = 0.25; - E18_DHAP_TP_Piap_kGAP_ch = 0.075; - E18_PGA_PGA_xpMult = 0.75; - E18_PGA_TP_Piap_vm = 250; - E18_PGA_TP_Piap_kPGA_ch = 0.25; - E18_PGA_TP_Piap_kPi_cyt = 0.74; - E18_PGA_TP_Piap_kPi_ch = 0.63; - E18_PGA_TP_Piap_kDHAP_ch = 0.077; - E18_PGA_TP_Piap_kGAP_ch = 0.075; - E18_GAP_TP_Piap_vm = 250; - E18_GAP_TP_Piap_kGAP_ch = 0.075; - E18_GAP_TP_Piap_kPi_cyt = 0.74; - E18_GAP_TP_Piap_kPi_ch = 0.63; - E18_GAP_TP_Piap_kPGA_ch = 0.25; - E18_GAP_TP_Piap_kDHAP_ch = 0.077; - - // Other declarations: - const chloroplast, cytosol, Light_on; - - // Unit definitions: - unit substance = 1e-3 mole; - - // Display Names: - substance is "mM"; - - // CV terms: - chloroplast identity "http://identifiers.org/go/GO:0009570" - cytosol identity "http://identifiers.org/go/GO:0005829" - x_CO2 identity "http://identifiers.org/chebi/CHEBI:16526", - "http://identifiers.org/kegg.compound/C00011" - RuBP_ch identity "http://identifiers.org/kegg.compound/C01182" - PGA_ch identity "http://identifiers.org/kegg.compound/C00197" - ATP_ch identity "http://identifiers.org/chebi/CHEBI:15422", - "http://identifiers.org/kegg.compound/C00002" - BPGA_ch identity "http://identifiers.org/kegg.compound/C00236" - x_NADPH_ch identity "http://identifiers.org/chebi/CHEBI:16474", - "http://identifiers.org/kegg.compound/C00005" - GAP_ch identity "http://identifiers.org/chebi/CHEBI:17138", - "http://identifiers.org/kegg.compound/C00118" - Pi_ch identity "http://identifiers.org/chebi/CHEBI:18367", - "http://identifiers.org/kegg.compound/C00009" - DHAP_ch identity "http://identifiers.org/chebi/CHEBI:16108", - "http://identifiers.org/kegg.compound/C00111" - FBP_ch identity "http://identifiers.org/chebi/CHEBI:28013", - "http://identifiers.org/kegg.compound/C05378" - F6P_ch hypernym "http://identifiers.org/chebi/CHEBI:57634" - E4P_ch identity "http://identifiers.org/chebi/CHEBI:48153", - "http://identifiers.org/kegg.compound/C00279" - X5P_ch identity "http://identifiers.org/chebi/CHEBI:16332", - "http://identifiers.org/kegg.compound/C00231" - SBP_ch identity "http://identifiers.org/chebi/CHEBI:17969", - "http://identifiers.org/kegg.compound/C00447" - S7P_ch identity "http://identifiers.org/chebi/CHEBI:15721", - "http://identifiers.org/kegg.compound/C05382" - R5P_ch identity "http://identifiers.org/chebi/CHEBI:17797", - "http://identifiers.org/kegg.compound/C00117" - Ru5P_ch identity "http://identifiers.org/chebi/CHEBI:17363", - "http://identifiers.org/kegg.compound/C00199" - x_Pi_cyt identity "http://identifiers.org/chebi/CHEBI:18367", - "http://identifiers.org/kegg.compound/C00009" - x_GAP_cyt identity "http://identifiers.org/chebi/CHEBI:17138", - "http://identifiers.org/kegg.compound/C00661" - G6P_ch identity "http://identifiers.org/chebi/CHEBI:14314", - "http://identifiers.org/kegg.compound/C00668" - x_NADP_ch identity "http://identifiers.org/chebi/CHEBI:18009", - "http://identifiers.org/kegg.compound/C00006" - x_PGA_cyt identity "http://identifiers.org/kegg.compound/C00197" - ADP_ch identity "http://identifiers.org/chebi/CHEBI:16761", - "http://identifiers.org/kegg.compound/C00008" - x_DHAP_cyt identity "http://identifiers.org/chebi/CHEBI:16108", - "http://identifiers.org/kegg.compound/C00111" - x_Proton_ch identity "http://identifiers.org/chebi/CHEBI:24636" - G1P_ch identity "http://identifiers.org/chebi/CHEBI:58601", - "http://identifiers.org/kegg.compound/C00103" - x_Starch_ch identity "http://identifiers.org/kegg.compound/C00369" - E1 hypernym "http://identifiers.org/ec-code/4.1.1.39" - E1 identity "http://identifiers.org/kegg.reaction/R00024" - E2 hypernym "http://identifiers.org/ec-code/2.7.2.3" - E2 identity "http://identifiers.org/kegg.reaction/R01512", - "http://identifiers.org/reactome/REACT_1186" - E3 hypernym "http://identifiers.org/ec-code/1.2.1.13" - E3 identity "http://identifiers.org/kegg.reaction/R01063" - E4 hypernym "http://identifiers.org/ec-code/5.3.1.1" - E4 identity "http://identifiers.org/kegg.reaction/R01015", - "http://identifiers.org/reactome/REACT_775" - E5 hypernym "http://identifiers.org/ec-code/4.1.2.13" - E5 identity "http://identifiers.org/kegg.reaction/R01070", - "http://identifiers.org/reactome/REACT_1602" - E6 hypernym "http://identifiers.org/ec-code/3.1.3.11" - E6 identity "http://identifiers.org/kegg.reaction/R04780" - E7 hypernym "http://identifiers.org/ec-code/2.2.1.1" - E7 identity "http://identifiers.org/kegg.reaction/R01830", - "http://identifiers.org/reactome/REACT_1811" - E8 hypernym "http://identifiers.org/ec-code/4.1.2.13" - E8 identity "http://identifiers.org/kegg.reaction/R01829" - E9 hypernym "http://identifiers.org/ec-code/3.1.3.37" - E9 identity "http://identifiers.org/kegg.reaction/R01845" - E10 hypernym "http://identifiers.org/ec-code/2.2.1.1" - E10 identity "http://identifiers.org/kegg.reaction/R01641", - "http://identifiers.org/reactome/REACT_1629" - E11 hypernym "http://identifiers.org/ec-code/5.3.1.6" - E11 identity "http://identifiers.org/kegg.reaction/R01056", - "http://identifiers.org/reactome/REACT_2033" - E12 hypernym "http://identifiers.org/ec-code/5.1.3.1" - E12 identity "http://identifiers.org/kegg.reaction/R01429", - "http://identifiers.org/reactome/REACT_1522" - E13 hypernym "http://identifiers.org/ec-code/2.7.1.19" - E13 identity "http://identifiers.org/kegg.reaction/R01423" - E14 hypernym "http://identifiers.org/ec-code/5.3.1.9" - E14 identity "http://identifiers.org/kegg.reaction/R00771", - "http://identifiers.org/reactome/REACT_1164" - E15 identity "http://identifiers.org/kegg.reaction/R00959" - E15 hypernym "http://identifiers.org/ec-code/5.4.2.2" - light_reaction hypernym "http://identifiers.org/go/GO:0006176" - E16 identity "http://identifiers.org/kegg.reaction/R02111" - E16 hypernym "http://identifiers.org/ec-code/2.4.1.1" - E17 identity "http://identifiers.org/kegg.reaction/R02111" - E17 hypernym "http://identifiers.org/ec-code/2.4.1.1" - E18_DHAP hypernym "http://identifiers.org/go/GO:0051407" - E18_PGA hypernym "http://identifiers.org/go/GO:0051408" - E18_GAP hypernym "http://identifiers.org/go/GO:0051408" -end - -untitled is "Poolman2004_CalvinCycle" - -untitled model_entity_is "http://identifiers.org/biomodels.db/MODEL6615594069" -untitled model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000013" -untitled description "http://identifiers.org/pubmed/15073223" -untitled taxon "http://identifiers.org/taxonomy/4097" -untitled hypernym "http://identifiers.org/go/GO:0019253" diff --git a/BioModelsRAG/data/BIOMD0000000014.txt b/BioModelsRAG/data/BIOMD0000000014.txt deleted file mode 100644 index 271ba48bdd7b4ce3cf3b726f2bb4c7eed9ab4bf7..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000014.txt +++ /dev/null @@ -1,1635 +0,0 @@ -// Created by libAntimony v2.13.0 -model *MAPK_in_Scaffold() - - // Compartments and Species: - compartment Cytoplasm; - substanceOnly species MAPKP in Cytoplasm, MEKP in Cytoplasm, RAFK in Cytoplasm; - substanceOnly species RAFP in Cytoplasm, K_1_0 in Cytoplasm, K_1_1 in Cytoplasm; - substanceOnly species K_1_2 in Cytoplasm, K_2_0 in Cytoplasm, K_2_1 in Cytoplasm; - substanceOnly species K_2_2 in Cytoplasm, K_3_0 in Cytoplasm, K_3_1 in Cytoplasm; - substanceOnly species K_K_1_0_2_2 in Cytoplasm, K_K_1_1_2_2 in Cytoplasm; - substanceOnly species K_K_2_0_3_1 in Cytoplasm, K_K_2_1_3_1 in Cytoplasm; - substanceOnly species K_MAPKP_1_1 in Cytoplasm, K_MAPKP_1_2 in Cytoplasm; - substanceOnly species K_MEKP_2_1 in Cytoplasm, K_MEKP_2_2 in Cytoplasm; - substanceOnly species K_RAFK_3_0 in Cytoplasm, K_RAFP_3_1 in Cytoplasm; - substanceOnly species S_m1_m1_m1 in Cytoplasm, S_m1_m1_0 in Cytoplasm, S_m1_m1_1 in Cytoplasm; - substanceOnly species S_m1_0_m1 in Cytoplasm, S_m1_0_0 in Cytoplasm, S_m1_0_1 in Cytoplasm; - substanceOnly species S_m1_1_m1 in Cytoplasm, S_m1_1_0 in Cytoplasm, S_m1_1_1 in Cytoplasm; - substanceOnly species S_m1_2_m1 in Cytoplasm, S_m1_2_0 in Cytoplasm, S_m1_2_1 in Cytoplasm; - substanceOnly species S_0_m1_m1 in Cytoplasm, S_0_m1_0 in Cytoplasm, S_0_m1_1 in Cytoplasm; - substanceOnly species S_0_0_m1 in Cytoplasm, S_0_0_0 in Cytoplasm, S_0_0_1 in Cytoplasm; - substanceOnly species S_0_1_m1 in Cytoplasm, S_0_1_0 in Cytoplasm, S_0_1_1 in Cytoplasm; - substanceOnly species S_0_2_m1 in Cytoplasm, S_0_2_0 in Cytoplasm, S_0_2_1 in Cytoplasm; - substanceOnly species S_1_m1_m1 in Cytoplasm, S_1_m1_0 in Cytoplasm, S_1_m1_1 in Cytoplasm; - substanceOnly species S_1_0_m1 in Cytoplasm, S_1_0_0 in Cytoplasm, S_1_0_1 in Cytoplasm; - substanceOnly species S_1_1_m1 in Cytoplasm, S_1_1_0 in Cytoplasm, S_1_1_1 in Cytoplasm; - substanceOnly species S_1_2_m1 in Cytoplasm, S_1_2_0 in Cytoplasm, S_1_2_1 in Cytoplasm; - substanceOnly species S_2_m1_m1 in Cytoplasm, S_2_m1_0 in Cytoplasm, S_2_m1_1 in Cytoplasm; - substanceOnly species S_2_0_m1 in Cytoplasm, S_2_0_0 in Cytoplasm, S_2_0_1 in Cytoplasm; - substanceOnly species S_2_1_m1 in Cytoplasm, S_2_1_0 in Cytoplasm, S_2_1_1 in Cytoplasm; - substanceOnly species S_2_2_m1 in Cytoplasm, S_2_2_0 in Cytoplasm, S_2_2_1 in Cytoplasm; - substanceOnly species S_RAFK_m1_m1_0 in Cytoplasm, S_RAFK_m1_0_0 in Cytoplasm; - substanceOnly species S_RAFK_m1_1_0 in Cytoplasm, S_RAFK_m1_2_0 in Cytoplasm; - substanceOnly species S_RAFK_0_m1_0 in Cytoplasm, S_RAFK_0_0_0 in Cytoplasm; - substanceOnly species S_RAFK_0_1_0 in Cytoplasm, S_RAFK_0_2_0 in Cytoplasm; - substanceOnly species S_RAFK_1_m1_0 in Cytoplasm, S_RAFK_1_0_0 in Cytoplasm; - substanceOnly species S_RAFK_1_1_0 in Cytoplasm, S_RAFK_1_2_0 in Cytoplasm; - substanceOnly species S_RAFK_2_m1_0 in Cytoplasm, S_RAFK_2_0_0 in Cytoplasm; - substanceOnly species S_RAFK_2_1_0 in Cytoplasm, S_RAFK_2_2_0 in Cytoplasm; - - // Reactions: - Reaction1: RAFK + K_3_0 => K_RAFK_3_0; Reaction1_a1*RAFK*K_3_0; - Reaction2: K_RAFK_3_0 => RAFK + K_3_0; Reaction2_d1*K_RAFK_3_0; - Reaction3: K_RAFK_3_0 => RAFK + K_3_1; Reaction3_k1*K_RAFK_3_0; - Reaction4: RAFP + K_3_1 => K_RAFP_3_1; Reaction4_a2*RAFP*K_3_1; - Reaction5: K_RAFP_3_1 => RAFP + K_3_1; Reaction5_d2*K_RAFP_3_1; - Reaction6: K_RAFP_3_1 => RAFP + K_3_0; Reaction6_k2*K_RAFP_3_1; - Reaction7: K_2_0 + K_3_1 => K_K_2_0_3_1; Reaction7_a3*K_2_0*K_3_1; - Reaction8: K_K_2_0_3_1 => K_2_0 + K_3_1; Reaction8_d3*K_K_2_0_3_1; - Reaction9: K_K_2_0_3_1 => K_2_1 + K_3_1; Reaction9_k3*K_K_2_0_3_1; - Reaction10: MEKP + K_2_1 => K_MEKP_2_1; Reaction10_a4*MEKP*K_2_1; - Reaction11: K_MEKP_2_1 => MEKP + K_2_1; Reaction11_d4*K_MEKP_2_1; - Reaction12: K_MEKP_2_1 => MEKP + K_2_0; Reaction12_k4*K_MEKP_2_1; - Reaction13: K_2_1 + K_3_1 => K_K_2_1_3_1; Reaction13_a5*K_2_1*K_3_1; - Reaction14: K_K_2_1_3_1 => K_2_1 + K_3_1; Reaction14_d5*K_K_2_1_3_1; - Reaction15: K_K_2_1_3_1 => K_2_2 + K_3_1; Reaction15_k5*K_K_2_1_3_1; - Reaction16: MEKP + K_2_2 => K_MEKP_2_2; Reaction16_a6*MEKP*K_2_2; - Reaction17: K_MEKP_2_2 => MEKP + K_2_2; Reaction17_d6*K_MEKP_2_2; - Reaction18: K_MEKP_2_2 => MEKP + K_2_1; Reaction18_k6*K_MEKP_2_2; - Reaction19: K_1_0 + K_2_2 => K_K_1_0_2_2; Reaction19_a7*K_1_0*K_2_2; - Reaction20: K_K_1_0_2_2 => K_1_0 + K_2_2; Reaction20_d7*K_K_1_0_2_2; - Reaction21: K_K_1_0_2_2 => K_1_1 + K_2_2; Reaction21_k7*K_K_1_0_2_2; - Reaction22: MAPKP + K_1_1 => K_MAPKP_1_1; Reaction22_a8*MAPKP*K_1_1; - Reaction23: K_MAPKP_1_1 => MAPKP + K_1_1; Reaction23_d8*K_MAPKP_1_1; - Reaction24: K_MAPKP_1_1 => MAPKP + K_1_0; Reaction24_k8*K_MAPKP_1_1; - Reaction25: K_1_1 + K_2_2 => K_K_1_1_2_2; Reaction25_a9*K_1_1*K_2_2; - Reaction26: K_K_1_1_2_2 => K_1_1 + K_2_2; Reaction26_d9*K_K_1_1_2_2; - Reaction27: K_K_1_1_2_2 => K_1_2 + K_2_2; Reaction27_k9*K_K_1_1_2_2; - Reaction28: MAPKP + K_1_2 => K_MAPKP_1_2; Reaction28_a10*MAPKP*K_1_2; - Reaction29: K_MAPKP_1_2 => MAPKP + K_1_2; Reaction29_d10*K_MAPKP_1_2; - Reaction30: K_MAPKP_1_2 => MAPKP + K_1_1; Reaction30_k10*K_MAPKP_1_2; - Reaction31: K_1_0 + S_m1_m1_m1 => S_0_m1_m1; Reaction31_kon*K_1_0*S_m1_m1_m1; - Reaction32: S_0_m1_m1 => K_1_0 + S_m1_m1_m1; Reaction32_koff*S_0_m1_m1; - Reaction33: K_1_0 + S_m1_m1_0 => S_0_m1_0; Reaction33_kon*K_1_0*S_m1_m1_0; - Reaction34: S_0_m1_0 => K_1_0 + S_m1_m1_0; Reaction34_koff*S_0_m1_0; - Reaction35: K_1_0 + S_m1_m1_1 => S_0_m1_1; Reaction35_kon*K_1_0*S_m1_m1_1; - Reaction36: S_0_m1_1 => K_1_0 + S_m1_m1_1; Reaction36_koff*S_0_m1_1; - Reaction37: K_1_0 + S_m1_0_m1 => S_0_0_m1; Reaction37_kon*K_1_0*S_m1_0_m1; - Reaction38: S_0_0_m1 => K_1_0 + S_m1_0_m1; Reaction38_koff*S_0_0_m1; - Reaction39: K_1_0 + S_m1_0_0 => S_0_0_0; Reaction39_kon*K_1_0*S_m1_0_0; - Reaction40: S_0_0_0 => K_1_0 + S_m1_0_0; Reaction40_koff*S_0_0_0; - Reaction41: K_1_0 + S_m1_0_1 => S_0_0_1; Reaction41_kon*K_1_0*S_m1_0_1; - Reaction42: S_0_0_1 => K_1_0 + S_m1_0_1; Reaction42_koff*S_0_0_1; - Reaction43: K_1_0 + S_m1_1_m1 => S_0_1_m1; Reaction43_kon*K_1_0*S_m1_1_m1; - Reaction44: S_0_1_m1 => K_1_0 + S_m1_1_m1; Reaction44_koff*S_0_1_m1; - Reaction45: K_1_0 + S_m1_1_0 => S_0_1_0; Reaction45_kon*K_1_0*S_m1_1_0; - Reaction46: S_0_1_0 => K_1_0 + S_m1_1_0; Reaction46_koff*S_0_1_0; - Reaction47: K_1_0 + S_m1_1_1 => S_0_1_1; Reaction47_kon*K_1_0*S_m1_1_1; - Reaction48: S_0_1_1 => K_1_0 + S_m1_1_1; Reaction48_koff*S_0_1_1; - Reaction49: K_1_0 + S_m1_2_m1 => S_0_2_m1; Reaction49_kon*K_1_0*S_m1_2_m1; - Reaction50: S_0_2_m1 => K_1_0 + S_m1_2_m1; Reaction50_koff*S_0_2_m1; - Reaction51: K_1_0 + S_m1_2_0 => S_0_2_0; Reaction51_kon*K_1_0*S_m1_2_0; - Reaction52: S_0_2_0 => K_1_0 + S_m1_2_0; Reaction52_koff*S_0_2_0; - Reaction53: K_1_0 + S_m1_2_1 => S_0_2_1; Reaction53_kon*K_1_0*S_m1_2_1; - Reaction54: S_0_2_1 => K_1_0 + S_m1_2_1; Reaction54_koff*S_0_2_1; - Reaction55: K_1_1 + S_m1_m1_m1 => S_1_m1_m1; Reaction55_kpon*K_1_1*S_m1_m1_m1; - Reaction56: S_1_m1_m1 => K_1_1 + S_m1_m1_m1; Reaction56_kpoff*S_1_m1_m1; - Reaction57: K_1_1 + S_m1_m1_0 => S_1_m1_0; Reaction57_kpon*K_1_1*S_m1_m1_0; - Reaction58: S_1_m1_0 => K_1_1 + S_m1_m1_0; Reaction58_kpoff*S_1_m1_0; - Reaction59: K_1_1 + S_m1_m1_1 => S_1_m1_1; Reaction59_kpon*K_1_1*S_m1_m1_1; - Reaction60: S_1_m1_1 => K_1_1 + S_m1_m1_1; Reaction60_kpoff*S_1_m1_1; - Reaction61: K_1_1 + S_m1_0_m1 => S_1_0_m1; Reaction61_kpon*K_1_1*S_m1_0_m1; - Reaction62: S_1_0_m1 => K_1_1 + S_m1_0_m1; Reaction62_kpoff*S_1_0_m1; - Reaction63: K_1_1 + S_m1_0_0 => S_1_0_0; Reaction63_kpon*K_1_1*S_m1_0_0; - Reaction64: S_1_0_0 => K_1_1 + S_m1_0_0; Reaction64_kpoff*S_1_0_0; - Reaction65: K_1_1 + S_m1_0_1 => S_1_0_1; Reaction65_kpon*K_1_1*S_m1_0_1; - Reaction66: S_1_0_1 => K_1_1 + S_m1_0_1; Reaction66_kpoff*S_1_0_1; - Reaction67: K_1_1 + S_m1_1_m1 => S_1_1_m1; Reaction67_kpon*K_1_1*S_m1_1_m1; - Reaction68: S_1_1_m1 => K_1_1 + S_m1_1_m1; Reaction68_kpoff*S_1_1_m1; - Reaction69: K_1_1 + S_m1_1_0 => S_1_1_0; Reaction69_kpon*K_1_1*S_m1_1_0; - Reaction70: S_1_1_0 => K_1_1 + S_m1_1_0; Reaction70_kpoff*S_1_1_0; - Reaction71: K_1_1 + S_m1_1_1 => S_1_1_1; Reaction71_kpon*K_1_1*S_m1_1_1; - Reaction72: S_1_1_1 => K_1_1 + S_m1_1_1; Reaction72_kpoff*S_1_1_1; - Reaction73: K_1_1 + S_m1_2_m1 => S_1_2_m1; Reaction73_kpon*K_1_1*S_m1_2_m1; - Reaction74: S_1_2_m1 => K_1_1 + S_m1_2_m1; Reaction74_kpoff*S_1_2_m1; - Reaction75: K_1_1 + S_m1_2_0 => S_1_2_0; Reaction75_kpon*K_1_1*S_m1_2_0; - Reaction76: S_1_2_0 => K_1_1 + S_m1_2_0; Reaction76_kpoff*S_1_2_0; - Reaction77: K_1_1 + S_m1_2_1 => S_1_2_1; Reaction77_kpon*K_1_1*S_m1_2_1; - Reaction78: S_1_2_1 => K_1_1 + S_m1_2_1; Reaction78_kpoff*S_1_2_1; - Reaction79: K_1_2 + S_m1_m1_m1 => S_2_m1_m1; Reaction79_kpon*K_1_2*S_m1_m1_m1; - Reaction80: S_2_m1_m1 => K_1_2 + S_m1_m1_m1; Reaction80_kpoff*S_2_m1_m1; - Reaction81: K_1_2 + S_m1_m1_0 => S_2_m1_0; Reaction81_kpon*K_1_2*S_m1_m1_0; - Reaction82: S_2_m1_0 => K_1_2 + S_m1_m1_0; Reaction82_kpoff*S_2_m1_0; - Reaction83: K_1_2 + S_m1_m1_1 => S_2_m1_1; Reaction83_kpon*K_1_2*S_m1_m1_1; - Reaction84: S_2_m1_1 => K_1_2 + S_m1_m1_1; Reaction84_kpoff*S_2_m1_1; - Reaction85: K_1_2 + S_m1_0_m1 => S_2_0_m1; Reaction85_kpon*K_1_2*S_m1_0_m1; - Reaction86: S_2_0_m1 => K_1_2 + S_m1_0_m1; Reaction86_kpoff*S_2_0_m1; - Reaction87: K_1_2 + S_m1_0_0 => S_2_0_0; Reaction87_kpon*K_1_2*S_m1_0_0; - Reaction88: S_2_0_0 => K_1_2 + S_m1_0_0; Reaction88_kpoff*S_2_0_0; - Reaction89: K_1_2 + S_m1_0_1 => S_2_0_1; Reaction89_kpon*K_1_2*S_m1_0_1; - Reaction90: S_2_0_1 => K_1_2 + S_m1_0_1; Reaction90_kpoff*S_2_0_1; - Reaction91: K_1_2 + S_m1_1_m1 => S_2_1_m1; Reaction91_kpon*K_1_2*S_m1_1_m1; - Reaction92: S_2_1_m1 => K_1_2 + S_m1_1_m1; Reaction92_kpoff*S_2_1_m1; - Reaction93: K_1_2 + S_m1_1_0 => S_2_1_0; Reaction93_kpon*K_1_2*S_m1_1_0; - Reaction94: S_2_1_0 => K_1_2 + S_m1_1_0; Reaction94_kpoff*S_2_1_0; - Reaction95: K_1_2 + S_m1_1_1 => S_2_1_1; Reaction95_kpon*K_1_2*S_m1_1_1; - Reaction96: S_2_1_1 => K_1_2 + S_m1_1_1; Reaction96_kpoff*S_2_1_1; - Reaction97: K_1_2 + S_m1_2_m1 => S_2_2_m1; Reaction97_kpon*K_1_2*S_m1_2_m1; - Reaction98: S_2_2_m1 => K_1_2 + S_m1_2_m1; Reaction98_kpoff*S_2_2_m1; - Reaction99: K_1_2 + S_m1_2_0 => S_2_2_0; Reaction99_kpon*K_1_2*S_m1_2_0; - Reaction100: S_2_2_0 => K_1_2 + S_m1_2_0; Reaction100_kpoff*S_2_2_0; - Reaction101: K_1_2 + S_m1_2_1 => S_2_2_1; Reaction101_kpon*K_1_2*S_m1_2_1; - Reaction102: S_2_2_1 => K_1_2 + S_m1_2_1; Reaction102_kpoff*S_2_2_1; - Reaction103: K_2_0 + S_m1_m1_m1 => S_m1_0_m1; Reaction103_kon*K_2_0*S_m1_m1_m1; - Reaction104: S_m1_0_m1 => K_2_0 + S_m1_m1_m1; Reaction104_koff*S_m1_0_m1; - Reaction105: K_2_0 + S_m1_m1_0 => S_m1_0_0; Reaction105_kon*K_2_0*S_m1_m1_0; - Reaction106: S_m1_0_0 => K_2_0 + S_m1_m1_0; Reaction106_koff*S_m1_0_0; - Reaction107: K_2_0 + S_m1_m1_1 => S_m1_0_1; Reaction107_kon*K_2_0*S_m1_m1_1; - Reaction108: S_m1_0_1 => K_2_0 + S_m1_m1_1; Reaction108_koff*S_m1_0_1; - Reaction109: K_2_1 + S_m1_m1_m1 => S_m1_1_m1; Reaction109_kpon*K_2_1*S_m1_m1_m1; - Reaction110: S_m1_1_m1 => K_2_1 + S_m1_m1_m1; Reaction110_kpoff*S_m1_1_m1; - Reaction111: K_2_1 + S_m1_m1_0 => S_m1_1_0; Reaction111_kpon*K_2_1*S_m1_m1_0; - Reaction112: S_m1_1_0 => K_2_1 + S_m1_m1_0; Reaction112_kpoff*S_m1_1_0; - Reaction113: K_2_1 + S_m1_m1_1 => S_m1_1_1; Reaction113_kpon*K_2_1*S_m1_m1_1; - Reaction114: S_m1_1_1 => K_2_1 + S_m1_m1_1; Reaction114_kpoff*S_m1_1_1; - Reaction115: K_2_2 + S_m1_m1_m1 => S_m1_2_m1; Reaction115_kpon*K_2_2*S_m1_m1_m1; - Reaction116: S_m1_2_m1 => K_2_2 + S_m1_m1_m1; Reaction116_kpoff*S_m1_2_m1; - Reaction117: K_2_2 + S_m1_m1_0 => S_m1_2_0; Reaction117_kpon*K_2_2*S_m1_m1_0; - Reaction118: S_m1_2_0 => K_2_2 + S_m1_m1_0; Reaction118_kpoff*S_m1_2_0; - Reaction119: K_2_2 + S_m1_m1_1 => S_m1_2_1; Reaction119_kpon*K_2_2*S_m1_m1_1; - Reaction120: S_m1_2_1 => K_2_2 + S_m1_m1_1; Reaction120_kpoff*S_m1_2_1; - Reaction121: K_2_0 + S_0_m1_m1 => S_0_0_m1; Reaction121_kon*K_2_0*S_0_m1_m1; - Reaction122: S_0_0_m1 => K_2_0 + S_0_m1_m1; Reaction122_koff*S_0_0_m1; - Reaction123: K_2_0 + S_0_m1_0 => S_0_0_0; Reaction123_kon*K_2_0*S_0_m1_0; - Reaction124: S_0_0_0 => K_2_0 + S_0_m1_0; Reaction124_koff*S_0_0_0; - Reaction125: K_2_0 + S_0_m1_1 => S_0_0_1; Reaction125_kon*K_2_0*S_0_m1_1; - Reaction126: S_0_0_1 => K_2_0 + S_0_m1_1; Reaction126_koff*S_0_0_1; - Reaction127: K_2_1 + S_0_m1_m1 => S_0_1_m1; Reaction127_kpon*K_2_1*S_0_m1_m1; - Reaction128: S_0_1_m1 => K_2_1 + S_0_m1_m1; Reaction128_kpoff*S_0_1_m1; - Reaction129: K_2_1 + S_0_m1_0 => S_0_1_0; Reaction129_kpon*K_2_1*S_0_m1_0; - Reaction130: S_0_1_0 => K_2_1 + S_0_m1_0; Reaction130_kpoff*S_0_1_0; - Reaction131: K_2_1 + S_0_m1_1 => S_0_1_1; Reaction131_kpon*K_2_1*S_0_m1_1; - Reaction132: S_0_1_1 => K_2_1 + S_0_m1_1; Reaction132_kpoff*S_0_1_1; - Reaction133: K_2_2 + S_0_m1_m1 => S_0_2_m1; Reaction133_kpon*K_2_2*S_0_m1_m1; - Reaction134: S_0_2_m1 => K_2_2 + S_0_m1_m1; Reaction134_kpoff*S_0_2_m1; - Reaction135: K_2_2 + S_0_m1_0 => S_0_2_0; Reaction135_kpon*K_2_2*S_0_m1_0; - Reaction136: S_0_2_0 => K_2_2 + S_0_m1_0; Reaction136_kpoff*S_0_2_0; - Reaction137: K_2_2 + S_0_m1_1 => S_0_2_1; Reaction137_kpon*K_2_2*S_0_m1_1; - Reaction138: S_0_2_1 => K_2_2 + S_0_m1_1; Reaction138_kpoff*S_0_2_1; - Reaction139: K_2_0 + S_1_m1_m1 => S_1_0_m1; Reaction139_kon*K_2_0*S_1_m1_m1; - Reaction140: S_1_0_m1 => K_2_0 + S_1_m1_m1; Reaction140_koff*S_1_0_m1; - Reaction141: K_2_0 + S_1_m1_0 => S_1_0_0; Reaction141_kon*K_2_0*S_1_m1_0; - Reaction142: S_1_0_0 => K_2_0 + S_1_m1_0; Reaction142_koff*S_1_0_0; - Reaction143: K_2_0 + S_1_m1_1 => S_1_0_1; Reaction143_kon*K_2_0*S_1_m1_1; - Reaction144: S_1_0_1 => K_2_0 + S_1_m1_1; Reaction144_koff*S_1_0_1; - Reaction145: K_2_1 + S_1_m1_m1 => S_1_1_m1; Reaction145_kpon*K_2_1*S_1_m1_m1; - Reaction146: S_1_1_m1 => K_2_1 + S_1_m1_m1; Reaction146_kpoff*S_1_1_m1; - Reaction147: K_2_1 + S_1_m1_0 => S_1_1_0; Reaction147_kpon*K_2_1*S_1_m1_0; - Reaction148: S_1_1_0 => K_2_1 + S_1_m1_0; Reaction148_kpoff*S_1_1_0; - Reaction149: K_2_1 + S_1_m1_1 => S_1_1_1; Reaction149_kpon*K_2_1*S_1_m1_1; - Reaction150: S_1_1_1 => K_2_1 + S_1_m1_1; Reaction150_kpoff*S_1_1_1; - Reaction151: K_2_2 + S_1_m1_m1 => S_1_2_m1; Reaction151_kpon*K_2_2*S_1_m1_m1; - Reaction152: S_1_2_m1 => K_2_2 + S_1_m1_m1; Reaction152_kpoff*S_1_2_m1; - Reaction153: K_2_2 + S_1_m1_0 => S_1_2_0; Reaction153_kpon*K_2_2*S_1_m1_0; - Reaction154: S_1_2_0 => K_2_2 + S_1_m1_0; Reaction154_kpoff*S_1_2_0; - Reaction155: K_2_2 + S_1_m1_1 => S_1_2_1; Reaction155_kpon*K_2_2*S_1_m1_1; - Reaction156: S_1_2_1 => K_2_2 + S_1_m1_1; Reaction156_kpoff*S_1_2_1; - Reaction157: K_2_0 + S_2_m1_m1 => S_2_0_m1; Reaction157_kon*K_2_0*S_2_m1_m1; - Reaction158: S_2_0_m1 => K_2_0 + S_2_m1_m1; Reaction158_koff*S_2_0_m1; - Reaction159: K_2_0 + S_2_m1_0 => S_2_0_0; Reaction159_kon*K_2_0*S_2_m1_0; - Reaction160: S_2_0_0 => K_2_0 + S_2_m1_0; Reaction160_koff*S_2_0_0; - Reaction161: K_2_0 + S_2_m1_1 => S_2_0_1; Reaction161_kon*K_2_0*S_2_m1_1; - Reaction162: S_2_0_1 => K_2_0 + S_2_m1_1; Reaction162_koff*S_2_0_1; - Reaction163: K_2_1 + S_2_m1_m1 => S_2_1_m1; Reaction163_kpon*K_2_1*S_2_m1_m1; - Reaction164: S_2_1_m1 => K_2_1 + S_2_m1_m1; Reaction164_kpoff*S_2_1_m1; - Reaction165: K_2_1 + S_2_m1_0 => S_2_1_0; Reaction165_kpon*K_2_1*S_2_m1_0; - Reaction166: S_2_1_0 => K_2_1 + S_2_m1_0; Reaction166_kpoff*S_2_1_0; - Reaction167: K_2_1 + S_2_m1_1 => S_2_1_1; Reaction167_kpon*K_2_1*S_2_m1_1; - Reaction168: S_2_1_1 => K_2_1 + S_2_m1_1; Reaction168_kpoff*S_2_1_1; - Reaction169: K_2_2 + S_2_m1_m1 => S_2_2_m1; Reaction169_kpon*K_2_2*S_2_m1_m1; - Reaction170: S_2_2_m1 => K_2_2 + S_2_m1_m1; Reaction170_kpoff*S_2_2_m1; - Reaction171: K_2_2 + S_2_m1_0 => S_2_2_0; Reaction171_kpon*K_2_2*S_2_m1_0; - Reaction172: S_2_2_0 => K_2_2 + S_2_m1_0; Reaction172_kpoff*S_2_2_0; - Reaction173: K_2_2 + S_2_m1_1 => S_2_2_1; Reaction173_kpon*K_2_2*S_2_m1_1; - Reaction174: S_2_2_1 => K_2_2 + S_2_m1_1; Reaction174_kpoff*S_2_2_1; - Reaction175: K_3_0 + S_m1_m1_m1 => S_m1_m1_0; Reaction175_kon*K_3_0*S_m1_m1_m1; - Reaction176: S_m1_m1_0 => K_3_0 + S_m1_m1_m1; Reaction176_koff*S_m1_m1_0; - Reaction177: K_3_1 + S_m1_m1_m1 => S_m1_m1_1; Reaction177_kpon*K_3_1*S_m1_m1_m1; - Reaction178: S_m1_m1_1 => K_3_1 + S_m1_m1_m1; Reaction178_kpoff*S_m1_m1_1; - Reaction179: K_3_0 + S_m1_0_m1 => S_m1_0_0; Reaction179_kon*K_3_0*S_m1_0_m1; - Reaction180: S_m1_0_0 => K_3_0 + S_m1_0_m1; Reaction180_koff*S_m1_0_0; - Reaction181: K_3_1 + S_m1_0_m1 => S_m1_0_1; Reaction181_kpon*K_3_1*S_m1_0_m1; - Reaction182: S_m1_0_1 => K_3_1 + S_m1_0_m1; Reaction182_kpoff*S_m1_0_1; - Reaction183: K_3_0 + S_m1_1_m1 => S_m1_1_0; Reaction183_kon*K_3_0*S_m1_1_m1; - Reaction184: S_m1_1_0 => K_3_0 + S_m1_1_m1; Reaction184_koff*S_m1_1_0; - Reaction185: K_3_1 + S_m1_1_m1 => S_m1_1_1; Reaction185_kpon*K_3_1*S_m1_1_m1; - Reaction186: S_m1_1_1 => K_3_1 + S_m1_1_m1; Reaction186_kpoff*S_m1_1_1; - Reaction187: K_3_0 + S_m1_2_m1 => S_m1_2_0; Reaction187_kon*K_3_0*S_m1_2_m1; - Reaction188: S_m1_2_0 => K_3_0 + S_m1_2_m1; Reaction188_koff*S_m1_2_0; - Reaction189: K_3_1 + S_m1_2_m1 => S_m1_2_1; Reaction189_kpon*K_3_1*S_m1_2_m1; - Reaction190: S_m1_2_1 => K_3_1 + S_m1_2_m1; Reaction190_kpoff*S_m1_2_1; - Reaction191: K_3_0 + S_0_m1_m1 => S_0_m1_0; Reaction191_kon*K_3_0*S_0_m1_m1; - Reaction192: S_0_m1_0 => K_3_0 + S_0_m1_m1; Reaction192_koff*S_0_m1_0; - Reaction193: K_3_1 + S_0_m1_m1 => S_0_m1_1; Reaction193_kpon*K_3_1*S_0_m1_m1; - Reaction194: S_0_m1_1 => K_3_1 + S_0_m1_m1; Reaction194_kpoff*S_0_m1_1; - Reaction195: K_3_0 + S_0_0_m1 => S_0_0_0; Reaction195_kon*K_3_0*S_0_0_m1; - Reaction196: S_0_0_0 => K_3_0 + S_0_0_m1; Reaction196_koff*S_0_0_0; - Reaction197: K_3_1 + S_0_0_m1 => S_0_0_1; Reaction197_kpon*K_3_1*S_0_0_m1; - Reaction198: S_0_0_1 => K_3_1 + S_0_0_m1; Reaction198_kpoff*S_0_0_1; - Reaction199: K_3_0 + S_0_1_m1 => S_0_1_0; Reaction199_kon*K_3_0*S_0_1_m1; - Reaction200: S_0_1_0 => K_3_0 + S_0_1_m1; Reaction200_koff*S_0_1_0; - Reaction201: K_3_1 + S_0_1_m1 => S_0_1_1; Reaction201_kpon*K_3_1*S_0_1_m1; - Reaction202: S_0_1_1 => K_3_1 + S_0_1_m1; Reaction202_kpoff*S_0_1_1; - Reaction203: K_3_0 + S_0_2_m1 => S_0_2_0; Reaction203_kon*K_3_0*S_0_2_m1; - Reaction204: S_0_2_0 => K_3_0 + S_0_2_m1; Reaction204_koff*S_0_2_0; - Reaction205: K_3_1 + S_0_2_m1 => S_0_2_1; Reaction205_kpon*K_3_1*S_0_2_m1; - Reaction206: S_0_2_1 => K_3_1 + S_0_2_m1; Reaction206_kpoff*S_0_2_1; - Reaction207: K_3_0 + S_1_m1_m1 => S_1_m1_0; Reaction207_kon*K_3_0*S_1_m1_m1; - Reaction208: S_1_m1_0 => K_3_0 + S_1_m1_m1; Reaction208_koff*S_1_m1_0; - Reaction209: K_3_1 + S_1_m1_m1 => S_1_m1_1; Reaction209_kpon*K_3_1*S_1_m1_m1; - Reaction210: S_1_m1_1 => K_3_1 + S_1_m1_m1; Reaction210_kpoff*S_1_m1_1; - Reaction211: K_3_0 + S_1_0_m1 => S_1_0_0; Reaction211_kon*K_3_0*S_1_0_m1; - Reaction212: S_1_0_0 => K_3_0 + S_1_0_m1; Reaction212_koff*S_1_0_0; - Reaction213: K_3_1 + S_1_0_m1 => S_1_0_1; Reaction213_kpon*K_3_1*S_1_0_m1; - Reaction214: S_1_0_1 => K_3_1 + S_1_0_m1; Reaction214_kpoff*S_1_0_1; - Reaction215: K_3_0 + S_1_1_m1 => S_1_1_0; Reaction215_kon*K_3_0*S_1_1_m1; - Reaction216: S_1_1_0 => K_3_0 + S_1_1_m1; Reaction216_koff*S_1_1_0; - Reaction217: K_3_1 + S_1_1_m1 => S_1_1_1; Reaction217_kpon*K_3_1*S_1_1_m1; - Reaction218: S_1_1_1 => K_3_1 + S_1_1_m1; Reaction218_kpoff*S_1_1_1; - Reaction219: K_3_0 + S_1_2_m1 => S_1_2_0; Reaction219_kon*K_3_0*S_1_2_m1; - Reaction220: S_1_2_0 => K_3_0 + S_1_2_m1; Reaction220_koff*S_1_2_0; - Reaction221: K_3_1 + S_1_2_m1 => S_1_2_1; Reaction221_kpon*K_3_1*S_1_2_m1; - Reaction222: S_1_2_1 => K_3_1 + S_1_2_m1; Reaction222_kpoff*S_1_2_1; - Reaction223: K_3_0 + S_2_m1_m1 => S_2_m1_0; Reaction223_kon*K_3_0*S_2_m1_m1; - Reaction224: S_2_m1_0 => K_3_0 + S_2_m1_m1; Reaction224_koff*S_2_m1_0; - Reaction225: K_3_1 + S_2_m1_m1 => S_2_m1_1; Reaction225_kpon*K_3_1*S_2_m1_m1; - Reaction226: S_2_m1_1 => K_3_1 + S_2_m1_m1; Reaction226_kpoff*S_2_m1_1; - Reaction227: K_3_0 + S_2_0_m1 => S_2_0_0; Reaction227_kon*K_3_0*S_2_0_m1; - Reaction228: S_2_0_0 => K_3_0 + S_2_0_m1; Reaction228_koff*S_2_0_0; - Reaction229: K_3_1 + S_2_0_m1 => S_2_0_1; Reaction229_kpon*K_3_1*S_2_0_m1; - Reaction230: S_2_0_1 => K_3_1 + S_2_0_m1; Reaction230_kpoff*S_2_0_1; - Reaction231: K_3_0 + S_2_1_m1 => S_2_1_0; Reaction231_kon*K_3_0*S_2_1_m1; - Reaction232: S_2_1_0 => K_3_0 + S_2_1_m1; Reaction232_koff*S_2_1_0; - Reaction233: K_3_1 + S_2_1_m1 => S_2_1_1; Reaction233_kpon*K_3_1*S_2_1_m1; - Reaction234: S_2_1_1 => K_3_1 + S_2_1_m1; Reaction234_kpoff*S_2_1_1; - Reaction235: K_3_0 + S_2_2_m1 => S_2_2_0; Reaction235_kon*K_3_0*S_2_2_m1; - Reaction236: S_2_2_0 => K_3_0 + S_2_2_m1; Reaction236_koff*S_2_2_0; - Reaction237: K_3_1 + S_2_2_m1 => S_2_2_1; Reaction237_kpon*K_3_1*S_2_2_m1; - Reaction238: S_2_2_1 => K_3_1 + S_2_2_m1; Reaction238_kpoff*S_2_2_1; - Reaction239: S_0_2_m1 => S_1_2_m1; Reaction239_k7*S_0_2_m1; - Reaction240: S_0_2_0 => S_1_2_0; Reaction240_k7*S_0_2_0; - Reaction241: S_0_2_1 => S_1_2_1; Reaction241_k7*S_0_2_1; - Reaction242: S_1_2_m1 => S_2_2_m1; Reaction242_k9a*S_1_2_m1; - Reaction243: S_1_2_0 => S_2_2_0; Reaction243_k9a*S_1_2_0; - Reaction244: S_1_2_1 => S_2_2_1; Reaction244_k9a*S_1_2_1; - Reaction245: S_m1_0_1 => S_m1_1_1; Reaction245_k3*S_m1_0_1; - Reaction246: S_m1_1_1 => S_m1_2_1; Reaction246_k5a*S_m1_1_1; - Reaction247: S_0_0_1 => S_0_1_1; Reaction247_k3*S_0_0_1; - Reaction248: S_0_1_1 => S_0_2_1; Reaction248_k5a*S_0_1_1; - Reaction249: S_1_0_1 => S_1_1_1; Reaction249_k3*S_1_0_1; - Reaction250: S_1_1_1 => S_1_2_1; Reaction250_k5a*S_1_1_1; - Reaction251: S_2_0_1 => S_2_1_1; Reaction251_k3*S_2_0_1; - Reaction252: S_2_1_1 => S_2_2_1; Reaction252_k5a*S_2_1_1; - Reaction253: RAFK + S_m1_m1_0 => S_RAFK_m1_m1_0; Reaction253_k1a*RAFK*S_m1_m1_0; - Reaction254: S_RAFK_m1_m1_0 => RAFK + S_m1_m1_0; Reaction254_d1a*S_RAFK_m1_m1_0; - Reaction255: S_RAFK_m1_m1_0 => RAFK + S_m1_m1_1; Reaction255_k1*S_RAFK_m1_m1_0; - Reaction256: RAFK + S_m1_0_0 => S_RAFK_m1_0_0; Reaction256_k1a*RAFK*S_m1_0_0; - Reaction257: S_RAFK_m1_0_0 => RAFK + S_m1_0_0; Reaction257_d1a*S_RAFK_m1_0_0; - Reaction258: S_RAFK_m1_0_0 => RAFK + S_m1_0_1; Reaction258_k1*S_RAFK_m1_0_0; - Reaction259: RAFK + S_m1_1_0 => S_RAFK_m1_1_0; Reaction259_k1a*RAFK*S_m1_1_0; - Reaction260: S_RAFK_m1_1_0 => RAFK + S_m1_1_0; Reaction260_d1a*S_RAFK_m1_1_0; - Reaction261: S_RAFK_m1_1_0 => RAFK + S_m1_1_1; Reaction261_k1*S_RAFK_m1_1_0; - Reaction262: RAFK + S_m1_2_0 => S_RAFK_m1_2_0; Reaction262_k1a*RAFK*S_m1_2_0; - Reaction263: S_RAFK_m1_2_0 => RAFK + S_m1_2_0; Reaction263_d1a*S_RAFK_m1_2_0; - Reaction264: S_RAFK_m1_2_0 => RAFK + S_m1_2_1; Reaction264_k1*S_RAFK_m1_2_0; - Reaction265: RAFK + S_0_m1_0 => S_RAFK_0_m1_0; Reaction265_k1a*RAFK*S_0_m1_0; - Reaction266: S_RAFK_0_m1_0 => RAFK + S_0_m1_0; Reaction266_d1a*S_RAFK_0_m1_0; - Reaction267: S_RAFK_0_m1_0 => RAFK + S_0_m1_1; Reaction267_k1*S_RAFK_0_m1_0; - Reaction268: RAFK + S_0_0_0 => S_RAFK_0_0_0; Reaction268_k1a*RAFK*S_0_0_0; - Reaction269: S_RAFK_0_0_0 => RAFK + S_0_0_0; Reaction269_d1a*S_RAFK_0_0_0; - Reaction270: S_RAFK_0_0_0 => RAFK + S_0_0_1; Reaction270_k1*S_RAFK_0_0_0; - Reaction271: RAFK + S_0_1_0 => S_RAFK_0_1_0; Reaction271_k1a*RAFK*S_0_1_0; - Reaction272: S_RAFK_0_1_0 => RAFK + S_0_1_0; Reaction272_d1a*S_RAFK_0_1_0; - Reaction273: S_RAFK_0_1_0 => RAFK + S_0_1_1; Reaction273_k1*S_RAFK_0_1_0; - Reaction274: RAFK + S_0_2_0 => S_RAFK_0_2_0; Reaction274_k1a*RAFK*S_0_2_0; - Reaction275: S_RAFK_0_2_0 => RAFK + S_0_2_0; Reaction275_d1a*S_RAFK_0_2_0; - Reaction276: S_RAFK_0_2_0 => RAFK + S_0_2_1; Reaction276_k1*S_RAFK_0_2_0; - Reaction277: RAFK + S_1_m1_0 => S_RAFK_1_m1_0; Reaction277_k1a*RAFK*S_1_m1_0; - Reaction278: S_RAFK_1_m1_0 => RAFK + S_1_m1_0; Reaction278_d1a*S_RAFK_1_m1_0; - Reaction279: S_RAFK_1_m1_0 => RAFK + S_1_m1_1; Reaction279_k1*S_RAFK_1_m1_0; - Reaction280: RAFK + S_1_0_0 => S_RAFK_1_0_0; Reaction280_k1a*RAFK*S_1_0_0; - Reaction281: S_RAFK_1_0_0 => RAFK + S_1_0_0; Reaction281_d1a*S_RAFK_1_0_0; - Reaction282: S_RAFK_1_0_0 => RAFK + S_1_0_1; Reaction282_k1*S_RAFK_1_0_0; - Reaction283: RAFK + S_1_1_0 => S_RAFK_1_1_0; Reaction283_k1a*RAFK*S_1_1_0; - Reaction284: S_RAFK_1_1_0 => RAFK + S_1_1_0; Reaction284_d1a*S_RAFK_1_1_0; - Reaction285: S_RAFK_1_1_0 => RAFK + S_1_1_1; Reaction285_k1*S_RAFK_1_1_0; - Reaction286: RAFK + S_1_2_0 => S_RAFK_1_2_0; Reaction286_k1a*RAFK*S_1_2_0; - Reaction287: S_RAFK_1_2_0 => RAFK + S_1_2_0; Reaction287_d1a*S_RAFK_1_2_0; - Reaction288: S_RAFK_1_2_0 => RAFK + S_1_2_1; Reaction288_k1*S_RAFK_1_2_0; - Reaction289: RAFK + S_2_m1_0 => S_RAFK_2_m1_0; Reaction289_k1a*RAFK*S_2_m1_0; - Reaction290: S_RAFK_2_m1_0 => RAFK + S_2_m1_0; Reaction290_d1a*S_RAFK_2_m1_0; - Reaction291: S_RAFK_2_m1_0 => RAFK + S_2_m1_1; Reaction291_k1*S_RAFK_2_m1_0; - Reaction292: RAFK + S_2_0_0 => S_RAFK_2_0_0; Reaction292_k1a*RAFK*S_2_0_0; - Reaction293: S_RAFK_2_0_0 => RAFK + S_2_0_0; Reaction293_d1a*S_RAFK_2_0_0; - Reaction294: S_RAFK_2_0_0 => RAFK + S_2_0_1; Reaction294_k1*S_RAFK_2_0_0; - Reaction295: RAFK + S_2_1_0 => S_RAFK_2_1_0; Reaction295_k1a*RAFK*S_2_1_0; - Reaction296: S_RAFK_2_1_0 => RAFK + S_2_1_0; Reaction296_d1a*S_RAFK_2_1_0; - Reaction297: S_RAFK_2_1_0 => RAFK + S_2_1_1; Reaction297_k1*S_RAFK_2_1_0; - Reaction298: RAFK + S_2_2_0 => S_RAFK_2_2_0; Reaction298_k1a*RAFK*S_2_2_0; - Reaction299: S_RAFK_2_2_0 => RAFK + S_2_2_0; Reaction299_d1a*S_RAFK_2_2_0; - Reaction300: S_RAFK_2_2_0 => RAFK + S_2_2_1; Reaction300_k1*S_RAFK_2_2_0; - - // Species initializations: - MAPKP = 0.3/Cytoplasm; - MEKP = 0.2/Cytoplasm; - RAFK = 0.1/Cytoplasm; - RAFP = 0.3/Cytoplasm; - K_1_0 = 0.4/Cytoplasm; - K_1_1 = 0; - K_1_2 = 0; - K_2_0 = 0.2/Cytoplasm; - K_2_1 = 0; - K_2_2 = 0; - K_3_0 = 0.3/Cytoplasm; - K_3_1 = 0; - K_K_1_0_2_2 = 0; - K_K_1_1_2_2 = 0; - K_K_2_0_3_1 = 0; - K_K_2_1_3_1 = 0; - K_MAPKP_1_1 = 0; - K_MAPKP_1_2 = 0; - K_MEKP_2_1 = 0; - K_MEKP_2_2 = 0; - K_RAFK_3_0 = 0; - K_RAFP_3_1 = 0; - S_m1_m1_m1 = 0.1/Cytoplasm; - S_m1_m1_0 = 0; - S_m1_m1_1 = 0; - S_m1_0_m1 = 0; - S_m1_0_0 = 0; - S_m1_0_1 = 0; - S_m1_1_m1 = 0; - S_m1_1_0 = 0; - S_m1_1_1 = 0; - S_m1_2_m1 = 0; - S_m1_2_0 = 0; - S_m1_2_1 = 0; - S_0_m1_m1 = 0; - S_0_m1_0 = 0; - S_0_m1_1 = 0; - S_0_0_m1 = 0; - S_0_0_0 = 0; - S_0_0_1 = 0; - S_0_1_m1 = 0; - S_0_1_0 = 0; - S_0_1_1 = 0; - S_0_2_m1 = 0; - S_0_2_0 = 0; - S_0_2_1 = 0; - S_1_m1_m1 = 0; - S_1_m1_0 = 0; - S_1_m1_1 = 0; - S_1_0_m1 = 0; - S_1_0_0 = 0; - S_1_0_1 = 0; - S_1_1_m1 = 0; - S_1_1_0 = 0; - S_1_1_1 = 0; - S_1_2_m1 = 0; - S_1_2_0 = 0; - S_1_2_1 = 0; - S_2_m1_m1 = 0; - S_2_m1_0 = 0; - S_2_m1_1 = 0; - S_2_0_m1 = 0; - S_2_0_0 = 0; - S_2_0_1 = 0; - S_2_1_m1 = 0; - S_2_1_0 = 0; - S_2_1_1 = 0; - S_2_2_m1 = 0; - S_2_2_0 = 0; - S_2_2_1 = 0; - S_RAFK_m1_m1_0 = 0; - S_RAFK_m1_0_0 = 0; - S_RAFK_m1_1_0 = 0; - S_RAFK_m1_2_0 = 0; - S_RAFK_0_m1_0 = 0; - S_RAFK_0_0_0 = 0; - S_RAFK_0_1_0 = 0; - S_RAFK_0_2_0 = 0; - S_RAFK_1_m1_0 = 0; - S_RAFK_1_0_0 = 0; - S_RAFK_1_1_0 = 0; - S_RAFK_1_2_0 = 0; - S_RAFK_2_m1_0 = 0; - S_RAFK_2_0_0 = 0; - S_RAFK_2_1_0 = 0; - S_RAFK_2_2_0 = 0; - - // Compartment initializations: - Cytoplasm = 1; - - // Variable initializations: - Reaction1_a1 = 1; - Reaction2_d1 = 0.4; - Reaction3_k1 = 0.1; - Reaction4_a2 = 0.5; - Reaction5_d2 = 0.5; - Reaction6_k2 = 0.1; - Reaction7_a3 = 3.3; - Reaction8_d3 = 0.42; - Reaction9_k3 = 0.1; - Reaction10_a4 = 10; - Reaction11_d4 = 0.8; - Reaction12_k4 = 0.1; - Reaction13_a5 = 3.3; - Reaction14_d5 = 0.4; - Reaction15_k5 = 0.1; - Reaction16_a6 = 10; - Reaction17_d6 = 0.8; - Reaction18_k6 = 0.1; - Reaction19_a7 = 20; - Reaction20_d7 = 0.6; - Reaction21_k7 = 0.1; - Reaction22_a8 = 5; - Reaction23_d8 = 0.4; - Reaction24_k8 = 0.1; - Reaction25_a9 = 20; - Reaction26_d9 = 0.6; - Reaction27_k9 = 0.1; - Reaction28_a10 = 5; - Reaction29_d10 = 0.4; - Reaction30_k10 = 0.1; - Reaction31_kon = 10; - Reaction32_koff = 0.5; - Reaction33_kon = 10; - Reaction34_koff = 0.5; - Reaction35_kon = 10; - Reaction36_koff = 0.5; - Reaction37_kon = 10; - Reaction38_koff = 0.5; - Reaction39_kon = 10; - Reaction40_koff = 0.5; - Reaction41_kon = 10; - Reaction42_koff = 0.5; - Reaction43_kon = 10; - Reaction44_koff = 0.5; - Reaction45_kon = 10; - Reaction46_koff = 0.5; - Reaction47_kon = 10; - Reaction48_koff = 0.5; - Reaction49_kon = 10; - Reaction50_koff = 0.5; - Reaction51_kon = 10; - Reaction52_koff = 0.5; - Reaction53_kon = 10; - Reaction54_koff = 0.5; - Reaction55_kpon = 0; - Reaction56_kpoff = 0.05; - Reaction57_kpon = 0; - Reaction58_kpoff = 0.05; - Reaction59_kpon = 0; - Reaction60_kpoff = 0.05; - Reaction61_kpon = 0; - Reaction62_kpoff = 0.05; - Reaction63_kpon = 0; - Reaction64_kpoff = 0.05; - Reaction65_kpon = 0; - Reaction66_kpoff = 0.05; - Reaction67_kpon = 0; - Reaction68_kpoff = 0.05; - Reaction69_kpon = 0; - Reaction70_kpoff = 0.05; - Reaction71_kpon = 0; - Reaction72_kpoff = 0.05; - Reaction73_kpon = 0; - Reaction74_kpoff = 0.05; - Reaction75_kpon = 0; - Reaction76_kpoff = 0.05; - Reaction77_kpon = 0; - Reaction78_kpoff = 0.05; - Reaction79_kpon = 0; - Reaction80_kpoff = 0.05; - Reaction81_kpon = 0; - Reaction82_kpoff = 0.05; - Reaction83_kpon = 0; - Reaction84_kpoff = 0.05; - Reaction85_kpon = 0; - Reaction86_kpoff = 0.05; - Reaction87_kpon = 0; - Reaction88_kpoff = 0.05; - Reaction89_kpon = 0; - Reaction90_kpoff = 0.05; - Reaction91_kpon = 0; - Reaction92_kpoff = 0.05; - Reaction93_kpon = 0; - Reaction94_kpoff = 0.05; - Reaction95_kpon = 0; - Reaction96_kpoff = 0.05; - Reaction97_kpon = 0; - Reaction98_kpoff = 0.05; - Reaction99_kpon = 0; - Reaction100_kpoff = 0.05; - Reaction101_kpon = 0; - Reaction102_kpoff = 0.05; - Reaction103_kon = 10; - Reaction104_koff = 0.5; - Reaction105_kon = 10; - Reaction106_koff = 0.5; - Reaction107_kon = 10; - Reaction108_koff = 0.5; - Reaction109_kpon = 0; - Reaction110_kpoff = 0.05; - Reaction111_kpon = 0; - Reaction112_kpoff = 0.05; - Reaction113_kpon = 0; - Reaction114_kpoff = 0.05; - Reaction115_kpon = 0; - Reaction116_kpoff = 0.05; - Reaction117_kpon = 0; - Reaction118_kpoff = 0.05; - Reaction119_kpon = 0; - Reaction120_kpoff = 0.05; - Reaction121_kon = 10; - Reaction122_koff = 0.5; - Reaction123_kon = 10; - Reaction124_koff = 0.5; - Reaction125_kon = 10; - Reaction126_koff = 0.5; - Reaction127_kpon = 0; - Reaction128_kpoff = 0.05; - Reaction129_kpon = 0; - Reaction130_kpoff = 0.05; - Reaction131_kpon = 0; - Reaction132_kpoff = 0.05; - Reaction133_kpon = 0; - Reaction134_kpoff = 0.05; - Reaction135_kpon = 0; - Reaction136_kpoff = 0.05; - Reaction137_kpon = 0; - Reaction138_kpoff = 0.05; - Reaction139_kon = 10; - Reaction140_koff = 0.5; - Reaction141_kon = 10; - Reaction142_koff = 0.5; - Reaction143_kon = 10; - Reaction144_koff = 0.5; - Reaction145_kpon = 0; - Reaction146_kpoff = 0.05; - Reaction147_kpon = 0; - Reaction148_kpoff = 0.05; - Reaction149_kpon = 0; - Reaction150_kpoff = 0.05; - Reaction151_kpon = 0; - Reaction152_kpoff = 0.05; - Reaction153_kpon = 0; - Reaction154_kpoff = 0.05; - Reaction155_kpon = 0; - Reaction156_kpoff = 0.05; - Reaction157_kon = 10; - Reaction158_koff = 0.5; - Reaction159_kon = 10; - Reaction160_koff = 0.5; - Reaction161_kon = 10; - Reaction162_koff = 0.5; - Reaction163_kpon = 0; - Reaction164_kpoff = 0.05; - Reaction165_kpon = 0; - Reaction166_kpoff = 0.05; - Reaction167_kpon = 0; - Reaction168_kpoff = 0.05; - Reaction169_kpon = 0; - Reaction170_kpoff = 0.05; - Reaction171_kpon = 0; - Reaction172_kpoff = 0.05; - Reaction173_kpon = 0; - Reaction174_kpoff = 0.05; - Reaction175_kon = 10; - Reaction176_koff = 0.5; - Reaction177_kpon = 0; - Reaction178_kpoff = 0.05; - Reaction179_kon = 10; - Reaction180_koff = 0.5; - Reaction181_kpon = 0; - Reaction182_kpoff = 0.05; - Reaction183_kon = 10; - Reaction184_koff = 0.5; - Reaction185_kpon = 0; - Reaction186_kpoff = 0.05; - Reaction187_kon = 10; - Reaction188_koff = 0.5; - Reaction189_kpon = 0; - Reaction190_kpoff = 0.05; - Reaction191_kon = 10; - Reaction192_koff = 0.5; - Reaction193_kpon = 0; - Reaction194_kpoff = 0.05; - Reaction195_kon = 10; - Reaction196_koff = 0.5; - Reaction197_kpon = 0; - Reaction198_kpoff = 0.05; - Reaction199_kon = 10; - Reaction200_koff = 0.5; - Reaction201_kpon = 0; - Reaction202_kpoff = 0.05; - Reaction203_kon = 10; - Reaction204_koff = 0.5; - Reaction205_kpon = 0; - Reaction206_kpoff = 0.05; - Reaction207_kon = 10; - Reaction208_koff = 0.5; - Reaction209_kpon = 0; - Reaction210_kpoff = 0.05; - Reaction211_kon = 10; - Reaction212_koff = 0.5; - Reaction213_kpon = 0; - Reaction214_kpoff = 0.05; - Reaction215_kon = 10; - Reaction216_koff = 0.5; - Reaction217_kpon = 0; - Reaction218_kpoff = 0.05; - Reaction219_kon = 10; - Reaction220_koff = 0.5; - Reaction221_kpon = 0; - Reaction222_kpoff = 0.05; - Reaction223_kon = 10; - Reaction224_koff = 0.5; - Reaction225_kpon = 0; - Reaction226_kpoff = 0.05; - Reaction227_kon = 10; - Reaction228_koff = 0.5; - Reaction229_kpon = 0; - Reaction230_kpoff = 0.05; - Reaction231_kon = 10; - Reaction232_koff = 0.5; - Reaction233_kpon = 0; - Reaction234_kpoff = 0.05; - Reaction235_kon = 10; - Reaction236_koff = 0.5; - Reaction237_kpon = 0; - Reaction238_kpoff = 0.05; - Reaction239_k7 = 0.1; - Reaction240_k7 = 0.1; - Reaction241_k7 = 0.1; - Reaction242_k9a = 0.1; - Reaction243_k9a = 0.1; - Reaction244_k9a = 0.1; - Reaction245_k3 = 0.1; - Reaction246_k5a = 0.1; - Reaction247_k3 = 0.1; - Reaction248_k5a = 0.1; - Reaction249_k3 = 0.1; - Reaction250_k5a = 0.1; - Reaction251_k3 = 0.1; - Reaction252_k5a = 0.1; - Reaction253_k1a = 100; - Reaction254_d1a = 0; - Reaction255_k1 = 0.1; - Reaction256_k1a = 100; - Reaction257_d1a = 0; - Reaction258_k1 = 0.1; - Reaction259_k1a = 100; - Reaction260_d1a = 0; - Reaction261_k1 = 0.1; - Reaction262_k1a = 100; - Reaction263_d1a = 0; - Reaction264_k1 = 0.1; - Reaction265_k1a = 100; - Reaction266_d1a = 0; - Reaction267_k1 = 0.1; - Reaction268_k1a = 100; - Reaction269_d1a = 0; - Reaction270_k1 = 0.1; - Reaction271_k1a = 100; - Reaction272_d1a = 0; - Reaction273_k1 = 0.1; - Reaction274_k1a = 100; - Reaction275_d1a = 0; - Reaction276_k1 = 0.1; - Reaction277_k1a = 100; - Reaction278_d1a = 0; - Reaction279_k1 = 0.1; - Reaction280_k1a = 100; - Reaction281_d1a = 0; - Reaction282_k1 = 0.1; - Reaction283_k1a = 100; - Reaction284_d1a = 0; - Reaction285_k1 = 0.1; - Reaction286_k1a = 100; - Reaction287_d1a = 0; - Reaction288_k1 = 0.1; - Reaction289_k1a = 100; - Reaction290_d1a = 0; - Reaction291_k1 = 0.1; - Reaction292_k1a = 100; - Reaction293_d1a = 0; - Reaction294_k1 = 0.1; - Reaction295_k1a = 100; - Reaction296_d1a = 0; - Reaction297_k1 = 0.1; - Reaction298_k1a = 100; - Reaction299_d1a = 0; - Reaction300_k1 = 0.1; - - // Other declarations: - const Cytoplasm; - - // Display Names: - MAPKP is "MAPK phosphatase"; - MEKP is "MEK phosphatase"; - RAFK is "RAF kinase"; - RAFP is "RAF phosphatase"; - K_1_0 is "MAPK"; - K_1_1 is "MAPK-P"; - K_1_2 is "MAPK-PP"; - K_2_0 is "MEK"; - K_2_1 is "MEK-P"; - K_2_2 is "MEK-PP"; - K_3_0 is "RAF"; - K_3_1 is "RAF-P"; - K_K_1_0_2_2 is "MAPK_MEK-PP"; - K_K_1_1_2_2 is "MAPK-P_MEK-PP"; - K_K_2_0_3_1 is "MEK_RAF-P"; - K_K_2_1_3_1 is "MEK-P_RAF-P"; - K_MAPKP_1_1 is "MAPK-P_MAPKPase"; - K_MAPKP_1_2 is "MAPK-PP_MAPKPase"; - K_MEKP_2_1 is "MEK-P_MEKPase"; - K_MEKP_2_2 is "MEK-PP_MEKPase"; - K_RAFK_3_0 is "RAF_RAFK"; - K_RAFP_3_1 is "RAF-P_RAFPase"; - S_m1_m1_m1 is "Scaffold"; - S_m1_m1_0 is "Scaffold_RAF"; - S_m1_m1_1 is "Scaffold_RAF-P"; - S_m1_0_m1 is "Scaffold_MEK"; - S_m1_0_0 is "Scaffold_MEK_RAF"; - S_m1_0_1 is "Scaffold_MEK_RAF-P"; - S_m1_1_m1 is "Scaffold_MEK-P"; - S_m1_1_0 is "Scaffold_MEK-P_RAF"; - S_m1_1_1 is "Scaffold_MEK-P_RAF-P"; - S_m1_2_m1 is "Scaffold_MEK-PP"; - S_m1_2_0 is "Scaffold_MEK-PP_RAF"; - S_m1_2_1 is "Scaffold_MEK-PP_RAF-P"; - S_0_m1_m1 is "Scaffold_MAPK"; - S_0_m1_0 is "Scaffold_MAPK_RAF"; - S_0_m1_1 is "Scaffold_MAPK_RAF-P"; - S_0_0_m1 is "Scaffold_MAPK_MEK"; - S_0_0_0 is "Scaffold_MAPK_MEK_RAF"; - S_0_0_1 is "Scaffold_MAPK_MEK_RAF-P"; - S_0_1_m1 is "Scaffold_MAPK_MEK-P"; - S_0_1_0 is "Scaffold_MAPK_MEK-P_RAF"; - S_0_1_1 is "Scaffold_MAPK_MEK-P_RAF-P"; - S_0_2_m1 is "Scaffold_MAPK_MEK-PP"; - S_0_2_0 is "Scaffold_MAPK_MEK-PP_RAF"; - S_0_2_1 is "Scaffold_MAPK_MEK-PP_RAF-P"; - S_1_m1_m1 is "Scaffold_MAPK-P"; - S_1_m1_0 is "Scaffold_MAPK-P_RAF"; - S_1_m1_1 is "Scaffold_MAPK-P_RAF-P"; - S_1_0_m1 is "Scaffold_MAPK-P_MEK"; - S_1_0_0 is "Scaffold_MAPK-P_MEK_RAF"; - S_1_0_1 is "Scaffold_MAPK-P_MEK_RAF-P"; - S_1_1_m1 is "Scaffold_MAPK-P_MEK-P"; - S_1_1_0 is "Scaffold_MAPK-P_MEK-P_RAF"; - S_1_1_1 is "Scaffold_MAPK-P_MEK-P_RAF-P"; - S_1_2_m1 is "Scaffold_MAPK-P_MEK-PP"; - S_1_2_0 is "Scaffold_MAPK-P_MEK-PP_RAF"; - S_1_2_1 is "Scaffold_MAPK-P_MEK-PP_RAF-P"; - S_2_m1_m1 is "Scaffold_MAPK-PP"; - S_2_m1_0 is "Scaffold_MAPK-PP_RAF"; - S_2_m1_1 is "Scaffold_MAPK-PP_RAF-P"; - S_2_0_m1 is "Scaffold_MAPK-PP_MEK"; - S_2_0_0 is "Scaffold_MAPK-PP_MEK_RAF"; - S_2_0_1 is "Scaffold_MAPK-PP_MEK_RAF-P"; - S_2_1_m1 is "Scaffold_MAPK-PP_MEK-P"; - S_2_1_0 is "Scaffold_MAPK-PP_MEK-P_RAF"; - S_2_1_1 is "Scaffold_MAPK-PP_MEK-P_RAF-P"; - S_2_2_m1 is "Scaffold_MAPK-PP_MEK-PP"; - S_2_2_0 is "Scaffold_MAPK-PP_MEK-PP_RAF"; - S_2_2_1 is "Scaffold_MAPK-PP_MEK-PP_RAF-P"; - S_RAFK_m1_m1_0 is "Scaffold_RAF"; - S_RAFK_m1_0_0 is "Scaffold_MEK_RAF"; - S_RAFK_m1_1_0 is "Scaffold_MEK-P_RAF"; - S_RAFK_m1_2_0 is "Scaffold_MEK-PP_RAF"; - S_RAFK_0_m1_0 is "Scaffold_MAPK_RAF"; - S_RAFK_0_0_0 is "Scaffold_MAPK_MEK_RAF"; - S_RAFK_0_1_0 is "Scaffold_MAPK_MEK-P_RAF"; - S_RAFK_0_2_0 is "Scaffold_MAPK_MEK-PP_RAF"; - S_RAFK_1_m1_0 is "Scaffold_MAPK-P_RAF"; - S_RAFK_1_0_0 is "Scaffold_MAPK-P_MEK_RAF"; - S_RAFK_1_1_0 is "Scaffold_MAPK-P_MEK-P_RAF"; - S_RAFK_1_2_0 is "Scaffold_MAPK-P_MEK-PP_RAF"; - S_RAFK_2_m1_0 is "Scaffold_MAPK-PP_RAF"; - S_RAFK_2_0_0 is "Scaffold_MAPK-PP_MEK_RAF"; - S_RAFK_2_1_0 is "Scaffold_MAPK-PP_MEK-P_RAF"; - S_RAFK_2_2_0 is "Scaffold_MAPK-PP_MEK-PP_RAF"; - Reaction1 is "binding of RAF and RAFK"; - Reaction2 is "dissociation of RAF_RAFK"; - Reaction3 is "phosphorylation of RAF"; - Reaction4 is "binding of RAF-P and RAF phosphatase"; - Reaction5 is "dissociation of RAF-P_RAFPase"; - Reaction6 is "dephosphorylation of RAF-P"; - Reaction7 is "binding of MEK and RAF-P"; - Reaction8 is "dissociation of MEK_RAF-P"; - Reaction9 is "phosphorylation of MEK"; - Reaction10 is "binding of MEK-P and MEK phosphatase"; - Reaction11 is "dissociation of MEK-P_MEKPase"; - Reaction12 is "dephosphorylation of MEK-P"; - Reaction13 is "binding of MEK-P and RAF-P"; - Reaction14 is "dissociation of MEK-P_RAF-P"; - Reaction15 is "phosphorylation of MEK-P"; - Reaction16 is "binding of MEK-PP and MEK phosphatase"; - Reaction17 is "dissociation of MEK-PP_MEKPase"; - Reaction18 is "dephosphorylation of MEK-PP"; - Reaction19 is "binding of MAPK and MEK-PP"; - Reaction20 is "dissociation of MAPK_MEK-PP"; - Reaction21 is "phosphorylation of MAPK"; - Reaction22 is "binding of MAPK-P and MAPK phosphatase"; - Reaction23 is "dissociation of MAPK-P_MAPKPase"; - Reaction24 is "dephosphorylation of MAPK-P"; - Reaction25 is "binding of MAPK-P and MEK-PP"; - Reaction26 is "dissociation of MAPK-P_MEK-PP"; - Reaction27 is "phosphorylation of MAPK-P"; - Reaction28 is "binding of MAPK-PP and MAPK phosphatase"; - Reaction29 is "dissociation of MAPK-PP_MAPKPase"; - Reaction30 is "dephosphorylation of MAPK-PP"; - Reaction31 is "binding of MAPK on scaffold"; - Reaction32 is "dissociation of MAPK from scaffold"; - Reaction33 is "binding of MAPK on scaffold"; - Reaction34 is "dissociation of MAPK from scaffold"; - Reaction35 is "binding of MAPK on scaffold"; - Reaction36 is "dissociation of MAPK from scaffold"; - Reaction37 is "binding of MAPK on scaffold"; - Reaction38 is "dissociation of MAPK from scaffold"; - Reaction39 is "binding of MAPK on scaffold"; - Reaction40 is "dissociation of MAPK from scaffold"; - Reaction41 is "binding of MAPK on scaffold"; - Reaction42 is "dissociation of MAPK from scaffold"; - Reaction43 is "binding of MAPK on scaffold"; - Reaction44 is "dissociation of MAPK from scaffold"; - Reaction45 is "binding of MAPK on scaffold"; - Reaction46 is "dissociation of MAPK from scaffold"; - Reaction47 is "binding of MAPK on scaffold"; - Reaction48 is "dissociation of MAPK from scaffold"; - Reaction49 is "binding of MAPK on scaffold"; - Reaction50 is "dissociation of MAPK from scaffold"; - Reaction51 is "binding of MAPK on scaffold"; - Reaction52 is "dissociation of MAPK from scaffold"; - Reaction53 is "binding of MAPK on scaffold"; - Reaction54 is "dissociation of MAPK from scaffold"; - Reaction55 is "binding of MAPK-P on scaffold"; - Reaction56 is "dissociation of MAPK-P from scaffold"; - Reaction57 is "binding of MAPK-P on scaffold"; - Reaction58 is "dissociation of MAPK-P from scaffold"; - Reaction59 is "binding of MAPK-P on scaffold"; - Reaction60 is "dissociation of MAPK-P from scaffold"; - Reaction61 is "binding of MAPK-P on scaffold"; - Reaction62 is "dissociation of MAPK-P from scaffold"; - Reaction63 is "binding of MAPK-P on scaffold"; - Reaction64 is "dissociation of MAPK-P from scaffold"; - Reaction65 is "binding of MAPK-P on scaffold"; - Reaction66 is "dissociation of MAPK-P from scaffold"; - Reaction67 is "binding of MAPK-P on scaffold"; - Reaction68 is "dissociation of MAPK-P from scaffold"; - Reaction69 is "binding of MAPK-P on scaffold"; - Reaction70 is "dissociation of MAPK-P from scaffold"; - Reaction71 is "binding of MAPK-P on scaffold"; - Reaction72 is "dissociation of MAPK-P from scaffold"; - Reaction73 is "binding of MAPK-P on scaffold"; - Reaction74 is "dissociation of MAPK-P from scaffold"; - Reaction75 is "binding of MAPK-P on scaffold"; - Reaction76 is "dissociation of MAPK-P from scaffold"; - Reaction77 is "binding of MAPK-P on scaffold"; - Reaction78 is "dissociation of MAPK-P from scaffold"; - Reaction79 is "binding of MAPK-PP on scaffold"; - Reaction80 is "dissociation of MAPK-PP from scaffold"; - Reaction81 is "binding of MAPK-PP on scaffold"; - Reaction82 is "dissociation of MAPK-PP from scaffold"; - Reaction83 is "binding of MAPK-PP on scaffold"; - Reaction84 is "dissociation of MAPK-PP from scaffold"; - Reaction85 is "binding of MAPK-PP on scaffold"; - Reaction86 is "dissociation of MAPK-PP from scaffold"; - Reaction87 is "binding of MAPK-PP on scaffold"; - Reaction88 is "dissociation of MAPK-PP from scaffold"; - Reaction89 is "binding of MAPK-PP on scaffold"; - Reaction90 is "dissociation of MAPK-PP from scaffold"; - Reaction91 is "binding of MAPK-PP on scaffold"; - Reaction92 is "dissociation of MAPK-PP from scaffold"; - Reaction93 is "binding of MAPK-PP on scaffold"; - Reaction94 is "dissociation of MAPK-PP from scaffold"; - Reaction95 is "binding of MAPK-PP on scaffold"; - Reaction96 is "dissociation of MAPK-PP from scaffold"; - Reaction97 is "binding of MAPK-PP on scaffold"; - Reaction98 is "dissociation of MAPK-PP from scaffold"; - Reaction99 is "binding of MAPK-PP on scaffold"; - Reaction100 is "dissociation of MAPK-PP from scaffold"; - Reaction101 is "binding of MAPK-PP on scaffold"; - Reaction102 is "dissociation of MAPK-PP from scaffold"; - Reaction103 is "binding of MEK on scaffold"; - Reaction104 is "dissociation of MEK from scaffold"; - Reaction105 is "binding of MEK on scaffold"; - Reaction106 is "dissociation of MEK from scaffold"; - Reaction107 is "binding of MEK on scaffold"; - Reaction108 is "dissociation of MEK from scaffold"; - Reaction109 is "binding of MEK-P on scaffold"; - Reaction110 is "dissociation of MEK-P from scaffold"; - Reaction111 is "binding of MEK-P on scaffold"; - Reaction112 is "dissociation of MEK-P from scaffold"; - Reaction113 is "binding of MEK-P on scaffold"; - Reaction114 is "dissociation of MEK-P from scaffold"; - Reaction115 is "binding of MEK-PP on scaffold"; - Reaction116 is "dissociation of MEK-PP from scaffold"; - Reaction117 is "binding of MEK-PP on scaffold"; - Reaction118 is "dissociation of MEK-PP from scaffold"; - Reaction119 is "binding of MEK-PP on scaffold"; - Reaction120 is "dissociation of MEK-PP from scaffold"; - Reaction121 is "binding of MEK on scaffold"; - Reaction122 is "dissociation of MEK from scaffold"; - Reaction123 is "binding of MEK on scaffold"; - Reaction124 is "dissociation of MEK from scaffold"; - Reaction125 is "binding of MEK on scaffold"; - Reaction126 is "dissociation of MEK from scaffold"; - Reaction127 is "binding of MEK-P on scaffold"; - Reaction128 is "dissociation of MEK-P from scaffold"; - Reaction129 is "binding of MEK-P on scaffold"; - Reaction130 is "dissociation of MEK-P from scaffold"; - Reaction131 is "binding of MEK-P on scaffold"; - Reaction132 is "dissociation of MEK-P from scaffold"; - Reaction133 is "binding of MEK-PP on scaffold"; - Reaction134 is "dissociation of MEK-PP from scaffold"; - Reaction135 is "binding of MEK-PP on scaffold"; - Reaction136 is "dissociation of MEK-PP from scaffold"; - Reaction137 is "binding of MEK-PP on scaffold"; - Reaction138 is "dissociation of MEK-PP from scaffold"; - Reaction139 is "binding of MEK on scaffold"; - Reaction140 is "dissociation of MEK from scaffold"; - Reaction141 is "binding of MEK on scaffold"; - Reaction142 is "dissociation of MEK from scaffold"; - Reaction143 is "binding of MEK on scaffold"; - Reaction144 is "dissociation of MEK from scaffold"; - Reaction145 is "binding of MEK-P on scaffold"; - Reaction146 is "dissociation of MEK-P from scaffold"; - Reaction147 is "binding of MEK-P on scaffold"; - Reaction148 is "dissociation of MEK-P from scaffold"; - Reaction149 is "binding of MEK-P on scaffold"; - Reaction150 is "dissociation of MEK-P from scaffold"; - Reaction151 is "binding of MEK-PP on scaffold"; - Reaction152 is "dissociation of MEK-PP from scaffold"; - Reaction153 is "binding of MEK-PP on scaffold"; - Reaction154 is "dissociation of MEK-PP from scaffold"; - Reaction155 is "binding of MEK-PP on scaffold"; - Reaction156 is "dissociation of MEK-PP from scaffold"; - Reaction157 is "binding of MEK on scaffold"; - Reaction158 is "dissociation of MEK from scaffold"; - Reaction159 is "binding of MEK on scaffold"; - Reaction160 is "dissociation of MEK from scaffold"; - Reaction161 is "binding of MEK on scaffold"; - Reaction162 is "dissociation of MEK from scaffold"; - Reaction163 is "binding of MEK-P on scaffold"; - Reaction164 is "dissociation of MEK-P from scaffold"; - Reaction165 is "binding of MEK-P on scaffold"; - Reaction166 is "dissociation of MEK-P from scaffold"; - Reaction167 is "binding of MEK-P on scaffold"; - Reaction168 is "dissociation of MEK-P from scaffold"; - Reaction169 is "binding of MEK-PP on scaffold"; - Reaction170 is "dissociation of MEK-PP from scaffold"; - Reaction171 is "binding of MEK-PP on scaffold"; - Reaction172 is "dissociation of MEK-PP from scaffold"; - Reaction173 is "binding of MEK-PP on scaffold"; - Reaction174 is "dissociation of MEK-PP from scaffold"; - Reaction175 is "binding of RAF on scaffold"; - Reaction176 is "dissociation of RAF from scaffold"; - Reaction177 is "binding of RAF-P on scaffold"; - Reaction178 is "dissociation of RAF-P from scaffold"; - Reaction179 is "binding of RAF on scaffold"; - Reaction180 is "dissociation of RAF from scaffold"; - Reaction181 is "binding of RAF-P on scaffold"; - Reaction182 is "dissociation of RAF-P from scaffold"; - Reaction183 is "binding of RAF on scaffold"; - Reaction184 is "dissociation of RAF from scaffold"; - Reaction185 is "binding of RAF-P on scaffold"; - Reaction186 is "dissociation of RAF-P from scaffold"; - Reaction187 is "binding of RAF on scaffold"; - Reaction188 is "dissociation of RAF from scaffold"; - Reaction189 is "binding of RAF-P on scaffold"; - Reaction190 is "dissociation of RAF-P from scaffold"; - Reaction191 is "binding of RAF on scaffold"; - Reaction192 is "dissociation of RAF from scaffold"; - Reaction193 is "binding of RAF-P on scaffold"; - Reaction194 is "dissociation of RAF-P from scaffold"; - Reaction195 is "binding of RAF on scaffold"; - Reaction196 is "dissociation of RAF from scaffold"; - Reaction197 is "binding of RAF-P on scaffold"; - Reaction198 is "dissociation of RAF from scaffold"; - Reaction199 is "binding of RAF on scaffold"; - Reaction200 is "dissociation of RAF from scaffold"; - Reaction201 is "binding of RAF-P on scaffold"; - Reaction202 is "dissociation of RAF-P from scaffold"; - Reaction203 is "binding of RAF on scaffold"; - Reaction204 is "dissociation of RAF from scaffold"; - Reaction205 is "binding of RAF-P on scaffold"; - Reaction206 is "dissociation of RAF-P from scaffold"; - Reaction207 is "binding of RAF on scaffold"; - Reaction208 is "dissociation of RAF from scaffold"; - Reaction209 is "binding of RAF-P on scaffold"; - Reaction210 is "dissociation of RAF-P from scaffold"; - Reaction211 is "binding of RAF on scaffold"; - Reaction212 is "dissociation of RAF from scaffold"; - Reaction213 is "binding of RAF-P on scaffold"; - Reaction214 is "dissociation of RAF-P from scaffold"; - Reaction215 is "binding of RAF on scaffold"; - Reaction216 is "dissociation of RAF from scaffold"; - Reaction217 is "binding of RAF-P on scaffold"; - Reaction218 is "dissociation of RAF-P from scaffold"; - Reaction219 is "binding of RAF on scaffold"; - Reaction220 is "dissociation of RAF from scaffold"; - Reaction221 is "binding of RAF-P on scaffold"; - Reaction222 is "dissociation of RAF-P from scaffold"; - Reaction223 is "binding of RAF on scaffold"; - Reaction224 is "dissociation of RAF from scaffold"; - Reaction225 is "binding of RAF-P on scaffold"; - Reaction226 is "dissociation of RAF-P from scaffold"; - Reaction227 is "binding of RAF on scaffold"; - Reaction228 is "dissociation of RAF from scaffold"; - Reaction229 is "binding of RAF-P on scaffold"; - Reaction230 is "dissociation of RAF-P from scaffold"; - Reaction231 is "binding of RAF on scaffold"; - Reaction232 is "dissociation of RAF from scaffold"; - Reaction233 is "binding of RAF-P on scaffold"; - Reaction234 is "dissociation of RAF-P from scaffold"; - Reaction235 is "binding of RAF on scaffold"; - Reaction236 is "dissociation of RAF from scaffold"; - Reaction237 is "binding of RAF-P on scaffold"; - Reaction238 is "dissociation of RAF-P from scaffold"; - Reaction239 is "phosphorylation of MAPK on scaffold"; - Reaction240 is "phosphorylation of MAPK on scaffold"; - Reaction241 is "phosphorylation of MAPK on scaffold"; - Reaction242 is "phosphorylation of MAPK-P on scaffold"; - Reaction243 is "phosphorylation of MAPK-P on scaffold"; - Reaction244 is "phosphorylation of MAPK-P on scaffold"; - Reaction245 is "phosphorylation of MEK on scaffold"; - Reaction246 is "phosphorylation of MEK-P on scaffold"; - Reaction247 is "phosphorylation of MEK on scaffold"; - Reaction248 is "phosphorylation of MEK-P on scaffold"; - Reaction249 is "phosphorylation of MEK on scaffold"; - Reaction250 is "phosphorylation of MEK-P on scaffold"; - Reaction251 is "phosphorylation of MEK on scaffold"; - Reaction252 is "phosphorylation of MEK-P on scaffold"; - Reaction253 is "binding of RAF and RAFK"; - Reaction254 is "dissociation of RAF_RAFK"; - Reaction255 is "phosphorylation of RAF on scaffold"; - Reaction256 is "binding of RAF and RAFK"; - Reaction257 is "dissociation of RAF_RAFK"; - Reaction258 is "phosphorylation of RAF on scaffold"; - Reaction259 is "binding of RAF and RAFK"; - Reaction260 is "dissociation of RAF_RAFK"; - Reaction261 is "phosphorylation of RAF on scaffold"; - Reaction262 is "binding of RAF and RAFK"; - Reaction263 is "dissociation of RAF_RAFK"; - Reaction264 is "phosphorylation of RAF on scaffold"; - Reaction265 is "binding of RAF and RAFK"; - Reaction266 is "dissociation of RAF_RAFK"; - Reaction267 is "phosphorylation of RAF on scaffold"; - Reaction268 is "binding of RAF and RAFK"; - Reaction269 is "dissociation of RAF_RAFK"; - Reaction270 is "phosphorylation of RAF on scaffold"; - Reaction271 is "binding of RAF and RAFK"; - Reaction272 is "dissociation of RAF_RAFK"; - Reaction273 is "phosphorylation of RAF on scaffold"; - Reaction274 is "binding of RAF and RAFK"; - Reaction275 is "dissociation of RAF_RAFK"; - Reaction276 is "phosphorylation of RAF on scaffold"; - Reaction277 is "binding of RAF and RAFK"; - Reaction278 is "dissociation of RAF_RAFK"; - Reaction279 is "phosphorylation of RAF on scaffold"; - Reaction280 is "binding of RAF and RAFK"; - Reaction281 is "dissociation of RAF_RAFK"; - Reaction282 is "phosphorylation of RAF on scaffold"; - Reaction283 is "binding of RAF and RAFK"; - Reaction284 is "dissociation of RAF_RAFK"; - Reaction285 is "phosphorylation of RAF on scaffold"; - Reaction286 is "binding of RAF and RAFK"; - Reaction287 is "dissociation of RAF_RAFK"; - Reaction288 is "phosphorylation of RAF on scaffold"; - Reaction289 is "binding of RAF and RAFK"; - Reaction290 is "dissociation of RAF_RAFK"; - Reaction291 is "phosphorylation of RAF on scaffold"; - Reaction292 is "binding of RAF and RAFK"; - Reaction293 is "dissociation of RAF_RAFK"; - Reaction294 is "phosphorylation of RAF on scaffold"; - Reaction295 is "binding of RAF and RAFK"; - Reaction296 is "dissociation of RAF_RAFK"; - Reaction297 is "phosphorylation of RAF on scaffold"; - Reaction298 is "binding of RAF and RAFK"; - Reaction299 is "dissociation of RAF_RAFK"; - Reaction300 is "phosphorylation of RAF on scaffold"; - - // CV terms: - Cytoplasm hypernym "http://identifiers.org/go/GO:0005737" - MAPKP identity "http://identifiers.org/uniprot/Q90W58" - RAFK hypernym "http://identifiers.org/interpro/IPR003577" - K_1_0 hypernym "http://identifiers.org/uniprot/P26696" - K_1_1 hypernym "http://identifiers.org/uniprot/P26696" - K_1_2 hypernym "http://identifiers.org/uniprot/P26696" - K_2_0 hypernym "http://identifiers.org/uniprot/Q05116" - K_2_1 hypernym "http://identifiers.org/uniprot/Q05116" - K_2_2 identity "http://identifiers.org/uniprot/Q05116" - K_3_0 hypernym "http://identifiers.org/uniprot/P09560" - K_3_1 hypernym "http://identifiers.org/uniprot/P09560" - K_K_1_0_2_2 part "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - K_K_1_1_2_2 part "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - K_K_2_0_3_1 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116" - K_K_2_1_3_1 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116" - K_MAPKP_1_1 part "http://identifiers.org/uniprot/P26696", - "http://identifiers.org/uniprot/Q90W58" - K_MAPKP_1_2 part "http://identifiers.org/uniprot/P26696", - "http://identifiers.org/uniprot/Q90W58" - K_MEKP_2_1 part "http://identifiers.org/uniprot/Q05116" - K_MEKP_2_2 part "http://identifiers.org/uniprot/Q05116" - K_RAFK_3_0 part "http://identifiers.org/uniprot/P09560" - K_RAFP_3_1 part "http://identifiers.org/uniprot/P09560" - S_m1_m1_0 part "http://identifiers.org/uniprot/P09560" - S_m1_m1_1 part "http://identifiers.org/uniprot/P09560" - S_m1_0_m1 part "http://identifiers.org/uniprot/Q05116" - S_m1_0_0 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116" - S_m1_0_1 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116" - S_m1_1_m1 part "http://identifiers.org/uniprot/Q05116" - S_m1_1_0 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116" - S_m1_1_1 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116" - S_m1_2_m1 part "http://identifiers.org/uniprot/Q05116" - S_m1_2_0 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116" - S_m1_2_1 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116" - S_0_m1_m1 part "http://identifiers.org/uniprot/P26696" - S_0_m1_0 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/P26696" - S_0_m1_1 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/P26696" - S_0_0_m1 part "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - S_0_0_0 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - S_0_0_1 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - S_0_1_m1 part "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - S_0_1_0 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - S_0_1_1 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - S_0_2_m1 part "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - S_0_2_0 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - S_0_2_1 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - S_1_m1_m1 part "http://identifiers.org/uniprot/P26696" - S_1_m1_0 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/P26696" - S_1_m1_1 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/P26696" - S_1_0_m1 part "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - S_1_0_0 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - S_1_0_1 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - S_1_1_m1 part "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - S_1_1_0 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - S_1_1_1 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - S_1_2_m1 part "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - S_1_2_0 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - S_1_2_1 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - S_2_m1_m1 part "http://identifiers.org/uniprot/P26696" - S_2_m1_0 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/P26696" - S_2_m1_1 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/P26696" - S_2_0_m1 part "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - S_2_0_0 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - S_2_0_1 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - S_2_1_m1 part "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - S_2_1_0 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - S_2_1_1 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - S_2_2_m1 part "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - S_2_2_0 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - S_2_2_1 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - S_RAFK_m1_m1_0 part "http://identifiers.org/uniprot/P09560" - S_RAFK_m1_0_0 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116" - S_RAFK_m1_1_0 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116" - S_RAFK_m1_2_0 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116" - S_RAFK_0_m1_0 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/P26696" - S_RAFK_0_0_0 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - S_RAFK_0_1_0 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - S_RAFK_0_2_0 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - S_RAFK_1_m1_0 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/P26696" - S_RAFK_1_0_0 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - S_RAFK_1_1_0 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - S_RAFK_1_2_0 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - S_RAFK_2_m1_0 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/P26696" - S_RAFK_2_0_0 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - S_RAFK_2_1_0 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - S_RAFK_2_2_0 part "http://identifiers.org/uniprot/P09560", - "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - Reaction1 homolog "http://identifiers.org/reactome/REACT_996" - Reaction1 hypernym "http://identifiers.org/go/GO:0031435", - "http://identifiers.org/go/GO:0006461" - Reaction2 hypernym "http://identifiers.org/go/GO:0043241" - Reaction3 hypernym "http://identifiers.org/ec-code/2.7.11.1", - "http://identifiers.org/go/GO:0008349", - "http://identifiers.org/go/GO:0000185" - Reaction4 hypernym "http://identifiers.org/go/GO:0031435" - Reaction5 hypernym "http://identifiers.org/go/GO:0043241" - Reaction6 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0006470" - Reaction7 hypernym "http://identifiers.org/go/GO:0031434", - "http://identifiers.org/go/GO:0031435" - Reaction7 homolog "http://identifiers.org/reactome/REACT_143" - Reaction8 hypernym "http://identifiers.org/go/GO:0043241" - Reaction9 hypernym "http://identifiers.org/ec-code/2.7.11.25", - "http://identifiers.org/go/GO:0004709", - "http://identifiers.org/go/GO:0006468" - Reaction10 hypernym "http://identifiers.org/go/GO:0031435" - Reaction11 hypernym "http://identifiers.org/go/GO:0043241" - Reaction12 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0006470" - Reaction13 hypernym "http://identifiers.org/go/GO:0031434", - "http://identifiers.org/go/GO:0031435" - Reaction13 homolog "http://identifiers.org/reactome/REACT_143" - Reaction14 hypernym "http://identifiers.org/go/GO:0043241" - Reaction15 hypernym "http://identifiers.org/ec-code/2.7.1.37", - "http://identifiers.org/go/GO:0000186", - "http://identifiers.org/go/GO:0004709", - "http://identifiers.org/go/GO:0006468" - Reaction15 homolog "http://identifiers.org/reactome/REACT_614" - Reaction16 hypernym "http://identifiers.org/go/GO:0031434" - Reaction17 hypernym "http://identifiers.org/go/GO:0043241" - Reaction18 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0006470" - Reaction19 hypernym "http://identifiers.org/go/GO:0051019", - "http://identifiers.org/go/GO:0031434" - Reaction19 homolog "http://identifiers.org/reactome/REACT_1780", - "http://identifiers.org/reactome/REACT_495" - Reaction20 hypernym "http://identifiers.org/go/GO:0043241" - Reaction21 hypernym "http://identifiers.org/ec-code/2.7.12.2", - "http://identifiers.org/go/GO:0004708", - "http://identifiers.org/go/GO:0006468" - Reaction21 homolog "http://identifiers.org/reactome/REACT_136", - "http://identifiers.org/reactome/REACT_2247" - Reaction22 hypernym "http://identifiers.org/go/GO:0051019" - Reaction23 hypernym "http://identifiers.org/go/GO:0043241" - Reaction24 hypernym "http://identifiers.org/ec-code/3.1.3.16" - Reaction25 hypernym "http://identifiers.org/go/GO:0051019" - Reaction26 hypernym "http://identifiers.org/go/GO:0043241" - Reaction27 hypernym "http://identifiers.org/ec-code/2.7.1.37", - "http://identifiers.org/go/GO:0000187", - "http://identifiers.org/go/GO:0004708" - Reaction28 hypernym "http://identifiers.org/go/GO:0051019" - Reaction29 hypernym "http://identifiers.org/go/GO:0043241" - Reaction30 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0000188" - Reaction31 hypernym "http://identifiers.org/go/GO:0051019" - Reaction32 hypernym "http://identifiers.org/go/GO:0043241" - Reaction33 hypernym "http://identifiers.org/go/GO:0051019" - Reaction34 hypernym "http://identifiers.org/go/GO:0043241" - Reaction35 hypernym "http://identifiers.org/go/GO:0051019" - Reaction36 hypernym "http://identifiers.org/go/GO:0043241" - Reaction37 hypernym "http://identifiers.org/go/GO:0051019" - Reaction38 hypernym "http://identifiers.org/go/GO:0043241" - Reaction39 hypernym "http://identifiers.org/go/GO:0051019" - Reaction40 hypernym "http://identifiers.org/go/GO:0043241" - Reaction41 hypernym "http://identifiers.org/go/GO:0051019" - Reaction42 hypernym "http://identifiers.org/go/GO:0043241" - Reaction43 hypernym "http://identifiers.org/go/GO:0051019" - Reaction44 hypernym "http://identifiers.org/go/GO:0043241" - Reaction45 hypernym "http://identifiers.org/go/GO:0051019" - Reaction46 hypernym "http://identifiers.org/go/GO:0043241" - Reaction47 hypernym "http://identifiers.org/go/GO:0051019" - Reaction48 hypernym "http://identifiers.org/go/GO:0043241" - Reaction49 hypernym "http://identifiers.org/go/GO:0051019" - Reaction50 hypernym "http://identifiers.org/go/GO:0043241" - Reaction51 hypernym "http://identifiers.org/go/GO:0051019" - Reaction52 hypernym "http://identifiers.org/go/GO:0043241" - Reaction53 hypernym "http://identifiers.org/go/GO:0051019" - 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"http://identifiers.org/go/GO:0031435" - Reaction296 hypernym "http://identifiers.org/go/GO:0043241" - Reaction297 hypernym "http://identifiers.org/ec-code/2.7.11.1", - "http://identifiers.org/go/GO:0008349", - "http://identifiers.org/go/GO:0000185" - Reaction298 hypernym "http://identifiers.org/reactome/REACT_996", - "http://identifiers.org/go/GO:0031435" - Reaction299 hypernym "http://identifiers.org/go/GO:0043241" - Reaction300 hypernym "http://identifiers.org/ec-code/2.7.11.1", - "http://identifiers.org/go/GO:0008349", - "http://identifiers.org/go/GO:0000185" -end - -MAPK_in_Scaffold is "Levchenko2000_MAPK_Scaffold" - -MAPK_in_Scaffold model_entity_is "http://identifiers.org/biomodels.db/MODEL6616691524" -MAPK_in_Scaffold model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000014" -MAPK_in_Scaffold description "http://identifiers.org/pubmed/10823939" -MAPK_in_Scaffold origin "http://identifiers.org/biomodels.db/BIOMD0000000011" -MAPK_in_Scaffold hypernym "http://identifiers.org/go/GO:0005078", - "http://identifiers.org/go/GO:0000165" -MAPK_in_Scaffold homolog "http://identifiers.org/reactome/REACT_634" -MAPK_in_Scaffold taxon "http://identifiers.org/taxonomy/8355" diff --git a/BioModelsRAG/data/BIOMD0000000015.txt b/BioModelsRAG/data/BIOMD0000000015.txt deleted file mode 100644 index 94e954d0c1f4b7cf796ce124a010e1a73e42a462..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000015.txt +++ /dev/null @@ -1,411 +0,0 @@ -// Created by libAntimony v2.13.0 -model *BIOMD0000000015() - - // Compartments and Species: - compartment cell; - substanceOnly species PRPP in cell, IMP in cell, SAMP in cell, ATP in cell; - substanceOnly species SAM in cell, Ade in cell, XMP in cell, GTP in cell; - substanceOnly species dATP in cell, dGTP in cell, RNA in cell, DNA_ in cell; - substanceOnly species HX in cell, Xa in cell, Gua in cell, UA in cell, $R5P in cell; - substanceOnly species $Pi in cell; - - // Reactions: - ada: ATP => HX; ada_aada*ATP^ada_fada4; - ade: Ade => ; ade_aade*Ade^ade_fade6; - adna: dATP => DNA_; adna_aadna*dATP^adna_fdnap9*dGTP^adna_fdnap10; - adrnr: ATP => dATP; adrnr_aadrnr*ATP^adrnr_fadrnr4*dATP^adrnr_fadrnr9*dGTP^adrnr_fadrnr10; - ampd: ATP => IMP; ampd_aampd*ATP^ampd_fampd4*GTP^ampd_fampd8*Pi^ampd_fampd18; - aprt: PRPP + Ade => ATP; aprt_aaprt*PRPP^aprt_faprt1*ATP^aprt_faprt4*Ade^aprt_faprt6; - arna: ATP => RNA; arna_aarna*ATP^arna_frnap4*GTP^arna_frnap8; - asuc: IMP => SAMP; asuc_aasuc*IMP^asuc_fasuc2*ATP^asuc_fasuc4*GTP^asuc_fasuc8*Pi^asuc_fasuc18; - asli: SAMP => ATP; asli_aasli*SAMP^asli_fasli3*ATP^asli_fasli4; - dada: dATP => HX; dada_adada*dATP^dada_fdada9; - den: PRPP => IMP; den_aden*PRPP^den_fden1*IMP^den_fden2*ATP^den_fden4*GTP^den_fden8*Pi^den_fden18; - dgnuc: dGTP => Gua; dgnuc_adgnuc*dGTP^dgnuc_fdgnuc10; - dnaa: DNA_ => dATP; dnaa_adnaa*DNA_^dnaa_fdnan12; - dnag: DNA_ => dGTP; dnag_adnag*DNA_^dnag_fdnan12; - gdna: dGTP => DNA_; gdna_agdna*dATP^gdna_fdnap9*dGTP^gdna_fdnap10; - gdrnr: GTP => dGTP; gdrnr_agdrnr*GTP^gdrnr_fgdrnr8*dATP^gdrnr_fgdrnr9*dGTP^gdrnr_fgdrnr10; - gmpr: GTP => IMP; gmpr_agmpr*IMP^gmpr_fgmpr2*ATP^gmpr_fgmpr4*XMP^gmpr_fgmpr7*GTP^gmpr_fgmpr8; - gmps: XMP => GTP; gmps_agmps*ATP^gmps_fgmps4*XMP^gmps_fgmps7; - gnuc: GTP => Gua; gnuc_agnuc*GTP^gnuc_fgnuc8*Pi^gnuc_fgnuc18; - gprt: Gua + PRPP => GTP; gprt_agprt*PRPP^gprt_fgprt1*GTP^gprt_fgprt8*Gua^gprt_fgprt15; - grna: GTP => RNA; grna_agrna*ATP^grna_frnap4*GTP^grna_frnap8; - gua: Gua => Xa; gua_agua*Gua^gua_fgua15; - hprt: HX + PRPP => IMP; hprt_ahprt*PRPP^hprt_fhprt1*IMP^hprt_fhprt2*HX^hprt_fhprt13; - hx: HX => ; hx_ahx*HX^hx_fhx13; - hxd: HX => Xa; hxd_ahxd*HX^hxd_fhxd13; - impd: IMP => XMP; impd_aimpd*IMP^impd_fimpd2*XMP^impd_fimpd7*GTP^impd_fimpd8; - inuc: IMP => HX; inuc_ainuc*IMP^inuc_finuc2*Pi^inuc_finuc18; - mat: ATP => SAM; mat_amat*ATP^mat_fmat4*SAM^mat_fmat5; - polyam: SAM => Ade; polyam_apolyam*SAM^polyam_fpolyam5; - prpps: $R5P => PRPP; prpps_aprpps*PRPP^prpps_fprpps1*ATP^prpps_fprpps4*GTP^prpps_fprpps8*R5P^prpps_fprpps17*Pi^prpps_fprpps18; - pyr: PRPP => ; pyr_apyr*PRPP^pyr_fpyr1; - rnaa: RNA => ATP; rnaa_arnaa*RNA^rnaa_frnan11; - rnag: RNA => GTP; rnag_arnag*RNA^rnag_frnan11; - trans: SAM => ATP; trans_atrans*SAM^trans_ftrans5; - ua: UA => ; ua_aua*UA^ua_fua16; - x: Xa => ; x_ax*Xa^x_fx14; - xd: Xa => UA; xd_axd*Xa^xd_fxd14; - - // Species initializations: - PRPP = 5.01742/cell; - IMP = 98.2634/cell; - SAMP = 0.198189/cell; - ATP = 2475.35/cell; - SAM = 3.99187/cell; - Ade = 0.98473/cell; - XMP = 24.793/cell; - GTP = 410.223/cell; - dATP = 6.01413/cell; - dGTP = 3.02581/cell; - RNA = 28680.5/cell; - DNA_ = 5179.34/cell; - HX = 9.51785/cell; - Xa = 5.05941/cell; - Gua = 5.50638/cell; - UA = 100.293/cell; - R5P = 18/cell; - Pi = 1400/cell; - - // Compartment initializations: - cell = 1; - - // Variable initializations: - ada_aada = 0.001062; - ada_fada4 = 0.97; - ade_aade = 0.01; - ade_fade6 = 0.55; - adna_aadna = 3.2789; - adna_fdnap9 = 0.42; - adna_fdnap10 = 0.33; - adrnr_aadrnr = 0.0602; - adrnr_fadrnr4 = 0.1; - adrnr_fadrnr9 = -0.3; - adrnr_fadrnr10 = 0.87; - ampd_aampd = 0.02688; - ampd_fampd4 = 0.8; - ampd_fampd8 = -0.03; - ampd_fampd18 = -0.1; - aprt_aaprt = 233.8; - aprt_faprt1 = 0.5; - aprt_faprt4 = -0.8; - aprt_faprt6 = 0.75; - arna_aarna = 614.5; - arna_frnap4 = 0.05; - arna_frnap8 = 0.13; - asuc_aasuc = 3.5932; - asuc_fasuc2 = 0.4; - asuc_fasuc4 = -0.24; - asuc_fasuc8 = 0.2; - asuc_fasuc18 = -0.05; - asli_aasli = 66544; - asli_fasli3 = 0.99; - asli_fasli4 = -0.95; - dada_adada = 0.03333; - dada_fdada9 = 1; - den_aden = 5.2728; - den_fden1 = 2; - den_fden2 = -0.06; - den_fden4 = -0.25; - den_fden8 = -0.2; - den_fden18 = -0.08; - dgnuc_adgnuc = 0.03333; - dgnuc_fdgnuc10 = 1; - dnaa_adnaa = 0.001938; - dnaa_fdnan12 = 1; - dnag_adnag = 0.001318; - dnag_fdnan12 = 1; - gdna_agdna = 2.2296; - gdna_fdnap9 = 0.42; - gdna_fdnap10 = 0.33; - gdrnr_agdrnr = 0.1199; - gdrnr_fgdrnr8 = 0.4; - gdrnr_fgdrnr9 = -1.2; - gdrnr_fgdrnr10 = -0.39; - gmpr_agmpr = 0.3005; - gmpr_fgmpr2 = -0.15; - gmpr_fgmpr4 = -0.07; - gmpr_fgmpr7 = -0.76; - gmpr_fgmpr8 = 0.7; - gmps_agmps = 0.3738; - gmps_fgmps4 = 0.12; - gmps_fgmps7 = 0.16; - gnuc_agnuc = 0.2511; - gnuc_fgnuc8 = 0.9; - gnuc_fgnuc18 = -0.34; - gprt_agprt = 361.69; - gprt_fgprt1 = 1.2; - gprt_fgprt8 = -1.2; - gprt_fgprt15 = 0.42; - grna_agrna = 409.6; - grna_frnap4 = 0.05; - grna_frnap8 = 0.13; - gua_agua = 0.4919; - gua_fgua15 = 0.5; - hprt_ahprt = 12.569; - hprt_fhprt1 = 1.1; - hprt_fhprt2 = -0.89; - hprt_fhprt13 = 0.48; - hx_ahx = 0.003793; - hx_fhx13 = 1.12; - hxd_ahxd = 0.2754; - hxd_fhxd13 = 0.65; - impd_aimpd = 1.2823; - impd_fimpd2 = 0.15; - impd_fimpd7 = -0.09; - impd_fimpd8 = -0.03; - inuc_ainuc = 0.9135; - inuc_finuc2 = 0.8; - inuc_finuc18 = -0.36; - mat_amat = 7.2067; - mat_fmat4 = 0.2; - mat_fmat5 = -0.6; - polyam_apolyam = 0.29; - polyam_fpolyam5 = 0.9; - prpps_aprpps = 0.9; - prpps_fprpps1 = -0.03; - prpps_fprpps4 = -0.45; - prpps_fprpps8 = -0.04; - prpps_fprpps17 = 0.65; - prpps_fprpps18 = 0.7; - pyr_apyr = 1.2951; - pyr_fpyr1 = 1.27; - rnaa_arnaa = 0.06923; - rnaa_frnan11 = 1; - rnag_arnag = 0.04615; - rnag_frnan11 = 1; - trans_atrans = 8.8539; - trans_ftrans5 = 0.33; - ua_aua = 8.744e-05; - ua_fua16 = 2.21; - x_ax = 0.0012; - x_fx14 = 2; - xd_axd = 0.949; - xd_fxd14 = 0.55; - - // Other declarations: - const cell; - - // Unit definitions: - unit substance = 1e-6 mole; - unit time_unit = 60 second; - - // Display Names: - substance is "micromole (default)"; - time_unit is "minute (default)"; - PRPP is "phosphoribosylpyrophosphate"; - IMP is "inosine monophosphate"; - SAMP is "adenylosuccinate"; - ATP is "ATP_ADP_AMP_Ado"; - SAM is "s-adenosyl-L-methionine"; - Ade is "adenine"; - XMP is "xanthosine monophosphate"; - GTP is "GTP_GDP_GMP"; - dATP is "dATP_dADP_dAMP_dAdo"; - dGTP is "dGTP_dGDP_dGMP"; - HX is "dIno_Ino_HX"; - Xa is "xanthine"; - Gua is "guanine"; - UA is "uric acid"; - R5P is "ribose-5-phosphate"; - Pi is "phosphate"; - - // CV terms: - cell hypernym "http://identifiers.org/go/GO:0005623" - PRPP identity "http://identifiers.org/chebi/CHEBI:17111", - "http://identifiers.org/kegg.compound/C00119" - IMP identity "http://identifiers.org/chebi/CHEBI:17202", - "http://identifiers.org/kegg.compound/C00130" - SAMP identity "http://identifiers.org/chebi/CHEBI:15919", - "http://identifiers.org/kegg.compound/C03794" - ATP part "http://identifiers.org/chebi/CHEBI:15422", - "http://identifiers.org/chebi/CHEBI:16335", - "http://identifiers.org/chebi/CHEBI:16027", - "http://identifiers.org/chebi/CHEBI:16761" - ATP part "http://identifiers.org/kegg.compound/C00008", - "http://identifiers.org/kegg.compound/C00212", - "http://identifiers.org/kegg.compound/C00020", - "http://identifiers.org/kegg.compound/C00002", - "http://identifiers.org/chebi/CHEBI:16761" - SAM identity "http://identifiers.org/chebi/CHEBI:15414", - "http://identifiers.org/kegg.compound/C00019" - Ade identity "http://identifiers.org/chebi/CHEBI:16708", - "http://identifiers.org/kegg.compound/C00147" - XMP identity "http://identifiers.org/chebi/CHEBI:15652", - "http://identifiers.org/kegg.compound/C00655" - GTP part "http://identifiers.org/kegg.compound/C00035", - "http://identifiers.org/kegg.compound/C00144", - "http://identifiers.org/kegg.compound/C00044", - "http://identifiers.org/chebi/CHEBI:17552" - GTP part "http://identifiers.org/chebi/CHEBI:17345", - "http://identifiers.org/chebi/CHEBI:17552", - "http://identifiers.org/chebi/CHEBI:15996" - dATP part "http://identifiers.org/kegg.compound/C00131", - "http://identifiers.org/kegg.compound/C00206", - "http://identifiers.org/kegg.compound/C00360", - "http://identifiers.org/kegg.compound/C00559", - "http://identifiers.org/chebi/CHEBI:16284" - dATP part "http://identifiers.org/chebi/CHEBI:16284", - "http://identifiers.org/chebi/CHEBI:16174", - "http://identifiers.org/chebi/CHEBI:17256", - "http://identifiers.org/chebi/CHEBI:17713" - dGTP part "http://identifiers.org/kegg.compound/C00286", - "http://identifiers.org/kegg.compound/C00362", - "http://identifiers.org/kegg.compound/C00361", - "http://identifiers.org/chebi/CHEBI:16497" - dGTP part "http://identifiers.org/chebi/CHEBI:28862", - "http://identifiers.org/chebi/CHEBI:16192", - "http://identifiers.org/chebi/CHEBI:16497" - RNA identity "http://identifiers.org/kegg.compound/C00046" - DNA_ identity "http://identifiers.org/kegg.compound/C00039", - "http://identifiers.org/chebi/CHEBI:16991" - HX part "http://identifiers.org/kegg.compound/C00262", - "http://identifiers.org/kegg.compound/C05512", - "http://identifiers.org/kegg.compound/C00294" - HX part "http://identifiers.org/chebi/CHEBI:17596", - "http://identifiers.org/chebi/CHEBI:17368", - "http://identifiers.org/chebi/CHEBI:28997" - Xa identity "http://identifiers.org/chebi/CHEBI:17712", - "http://identifiers.org/kegg.compound/C00385" - Gua part "http://identifiers.org/kegg.compound/C00242", - "http://identifiers.org/kegg.compound/C00330", - "http://identifiers.org/kegg.compound/C00387" - Gua part "http://identifiers.org/chebi/CHEBI:16450", - "http://identifiers.org/chebi/CHEBI:16235", - "http://identifiers.org/chebi/CHEBI:17172" - UA identity "http://identifiers.org/chebi/CHEBI:17775", - "http://identifiers.org/kegg.compound/C00366" - R5P identity "http://identifiers.org/chebi/CHEBI:17797", - "http://identifiers.org/kegg.compound/C00117" - Pi identity "http://identifiers.org/chebi/CHEBI:18367", - "http://identifiers.org/kegg.compound/C00009" - ada hypernym "http://identifiers.org/ec-code/3.5.4.4" - ada version "http://identifiers.org/kegg.reaction/R01560", - "http://identifiers.org/reactome/REACT_1687" - ade hypernym "http://identifiers.org/go/GO:0006146" - adna hypernym "http://identifiers.org/ec-code/2.7.7.7" - adna identity "http://identifiers.org/kegg.reaction/R00375" - adrnr version "http://identifiers.org/ec-code/1.17.4.2", - "http://identifiers.org/ec-code/1.17.4.1", - "http://identifiers.org/kegg.reaction/R02017", - "http://identifiers.org/kegg.reaction/R02014", - "http://identifiers.org/reactome/REACT_2136" - ampd identity "http://identifiers.org/kegg.reaction/R00181" - ampd hypernym "http://identifiers.org/ec-code/3.5.4.6" - aprt hypernym "http://identifiers.org/ec-code/2.4.2.7" - aprt identity "http://identifiers.org/kegg.reaction/R00190" - arna hypernym "http://identifiers.org/ec-code/2.7.7.6" - arna identity "http://identifiers.org/kegg.reaction/R00435" - asuc hypernym "http://identifiers.org/ec-code/6.3.4.4" - asuc identity "http://identifiers.org/kegg.reaction/R01135", - "http://identifiers.org/reactome/REACT_42" - asli hypernym "http://identifiers.org/ec-code/4.3.2.2" - asli identity "http://identifiers.org/kegg.reaction/R01083", - "http://identifiers.org/reactome/REACT_1042" - dada hypernym "http://identifiers.org/ec-code/3.5.4.4" - dada identity "http://identifiers.org/kegg.reaction/R02556", - "http://identifiers.org/reactome/REACT_2135" - den part "http://identifiers.org/reactome/REACT_108", - "http://identifiers.org/reactome/REACT_812", - "http://identifiers.org/reactome/REACT_1463", - "http://identifiers.org/reactome/REACT_589", - "http://identifiers.org/reactome/REACT_1917", - "http://identifiers.org/reactome/REACT_1509", - "http://identifiers.org/reactome/REACT_740", - "http://identifiers.org/reactome/REACT_285", - "http://identifiers.org/reactome/REACT_1427", - "http://identifiers.org/reactome/REACT_263" - den part "http://identifiers.org/ec-code/2.4.2.14", - "http://identifiers.org/ec-code/6.3.4.13", - "http://identifiers.org/ec-code/2.1.2.2", - "http://identifiers.org/ec-code/6.3.5.3", - "http://identifiers.org/ec-code/6.3.3.1", - "http://identifiers.org/ec-code/4.1.1.21", - "http://identifiers.org/ec-code/6.3.2.6", - "http://identifiers.org/ec-code/4.3.2.2", - "http://identifiers.org/ec-code/2.1.2.3", - "http://identifiers.org/ec-code/3.5.4.10" - den part "http://identifiers.org/kegg.reaction/R04144", - "http://identifiers.org/kegg.reaction/R04325", - "http://identifiers.org/kegg.reaction/R04463", - "http://identifiers.org/kegg.reaction/R04208", - "http://identifiers.org/kegg.reaction/R04209", - "http://identifiers.org/kegg.reaction/R04559", - "http://identifiers.org/kegg.reaction/R04560", - "http://identifiers.org/kegg.reaction/R04591", - "http://identifiers.org/kegg.reaction/R01127", - "http://identifiers.org/kegg.reaction/R01072" - dgnuc hypernym "http://identifiers.org/ec-code/3.1.3.5" - dgnuc identity "http://identifiers.org/kegg.reaction/R01968", - "http://identifiers.org/reactome/REACT_1209" - dnaa hypernym "http://identifiers.org/go/GO:0006308" - dnag hypernym "http://identifiers.org/go/GO:0006308" - gdna identity "http://identifiers.org/kegg.reaction/R00376" - gdna hypernym "http://identifiers.org/ec-code/2.7.7.7" - gdrnr version "http://identifiers.org/ec-code/1.17.4.2", - "http://identifiers.org/ec-code/1.17.4.1", - "http://identifiers.org/kegg.reaction/R02019", - "http://identifiers.org/kegg.reaction/R02020", - "http://identifiers.org/reactome/REACT_906" - gmpr hypernym "http://identifiers.org/ec-code/1.7.1.7" - gmpr identity "http://identifiers.org/kegg.reaction/R01134" - gmps hypernym "http://identifiers.org/ec-code/6.3.5.2" - gmps identity "http://identifiers.org/kegg.reaction/R01231", - "http://identifiers.org/reactome/REACT_628" - gnuc hypernym "http://identifiers.org/ec-code/3.1.3.5" - gnuc identity "http://identifiers.org/kegg.reaction/R01227", - "http://identifiers.org/reactome/REACT_1774" - gprt hypernym "http://identifiers.org/ec-code/2.4.2.7" - gprt identity "http://identifiers.org/kegg.reaction/R01229" - grna hypernym "http://identifiers.org/ec-code/2.7.7.6" - grna identity "http://identifiers.org/kegg.reaction/R00441" - gua hypernym "http://identifiers.org/ec-code/3.5.4.3" - gua identity "http://identifiers.org/kegg.reaction/R01676", - "http://identifiers.org/reactome/REACT_1442" - hprt hypernym "http://identifiers.org/ec-code/2.4.2.8" - hprt identity "http://identifiers.org/kegg.reaction/R01132" - hx hypernym "http://identifiers.org/go/GO:0009114" - hxd hypernym "http://identifiers.org/ec-code/1.17.3.2" - hxd identity "http://identifiers.org/kegg.reaction/R01769", - "http://identifiers.org/reactome/REACT_401" - impd hypernym "http://identifiers.org/ec-code/1.1.1.205" - impd identity "http://identifiers.org/kegg.reaction/R01130", - "http://identifiers.org/reactome/REACT_1488" - inuc identity "http://identifiers.org/kegg.reaction/R01126", - "http://identifiers.org/reactome/REACT_430" - inuc hypernym "http://identifiers.org/ec-code/3.1.3.5" - mat identity "http://identifiers.org/kegg.reaction/R00177" - mat hypernym "http://identifiers.org/ec-code/2.5.1.6" - polyam part "http://identifiers.org/kegg.reaction/R02869", - "http://identifiers.org/kegg.reaction/R00178", - "http://identifiers.org/kegg.reaction/R01401" - polyam part "http://identifiers.org/ec-code/3.2.2.16", - "http://identifiers.org/ec-code/2.5.1.22", - "http://identifiers.org/ec-code/4.1.1.50" - polyam parthood "http://identifiers.org/kegg.pathway/map00330" - prpps identity "http://identifiers.org/kegg.reaction/R01049" - prpps hypernym "http://identifiers.org/ec-code/2.7.6.1" - pyr identity "http://identifiers.org/kegg.reaction/R01870", - "http://identifiers.org/reactome/REACT_33" - pyr parthood "http://identifiers.org/kegg.pathway/map00240" - pyr hypernym "http://identifiers.org/ec-code/2.4.2.10" - rnaa hypernym "http://identifiers.org/go/GO:0006401" - rnag hypernym "http://identifiers.org/go/GO:0006401" - trans identity "http://identifiers.org/go/GO:0008757" - ua hypernym "http://identifiers.org/go/GO:0007588" - x hypernym "http://identifiers.org/go/GO:0009115" - xd identity "http://identifiers.org/kegg.reaction/R02107", - "http://identifiers.org/reactome/REACT_624" - xd hypernym "http://identifiers.org/ec-code/1.17.3.2" -end - -BIOMD0000000015 is "Curto1998 - purine metabolism" - -BIOMD0000000015 model_entity_is "http://identifiers.org/biomodels.db/MODEL6617035399" -BIOMD0000000015 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000015" -BIOMD0000000015 description "http://identifiers.org/pubmed/9664759" -BIOMD0000000015 taxon "http://identifiers.org/taxonomy/9606" -BIOMD0000000015 identity "http://identifiers.org/kegg.pathway/hsa00230", - "http://identifiers.org/reactome/REACT_522" -BIOMD0000000015 hypernym "http://identifiers.org/go/GO:0006144" diff --git a/BioModelsRAG/data/BIOMD0000000016.txt b/BioModelsRAG/data/BIOMD0000000016.txt deleted file mode 100644 index 28c3c4881dcfb4cfe6b37684ef2ed8976b4b95d8..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000016.txt +++ /dev/null @@ -1,119 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Goldbeter1995() - - // Compartments and Species: - compartment default, CYTOPLASM, compartment_0000004; - species $EmptySet in default, M in CYTOPLASM, P0 in CYTOPLASM, P1 in CYTOPLASM; - species P2 in CYTOPLASM, Pn in compartment_0000004, $Pt in CYTOPLASM; - - // Assignment Rules: - Pt := P0 + P1 + P2 + Pn; - - // Reactions: - rM: $EmptySet => M; default*rM_Vs*rM_KI^rM_n/(rM_KI^rM_n + Pn^rM_n); - rTL: $EmptySet => P0; rTL_ks*M*default; - rP01: P0 => P1; CYTOPLASM*rP01_V1*P0/(rP01_K1 + P0); - rP10: P1 => P0; CYTOPLASM*rP10_V2*P1/(rP10_K2 + P1); - rP12: P1 => P2; CYTOPLASM*rP12_V3*P1/(rP12_K3 + P1); - rP21: P2 => P1; CYTOPLASM*rP21_V4*P2/(rP21_K4 + P2); - rP2n: P2 => Pn; rP2n_k1*P2*CYTOPLASM; - rPn2: Pn => P2; rPn2_k2*Pn*compartment_0000004; - rmRNAd: M => $EmptySet; rmRNAd_Vm*M*CYTOPLASM/(rmRNAd_Km + M); - rVd: P2 => $EmptySet; CYTOPLASM*rVd_Vd*P2/(rVd_Kd + P2); - - // Species initializations: - EmptySet = 0; - M = 0.1; - P0 = 0.25; - P1 = 0.25; - P2 = 0.25; - Pn = 0.25; - - // Compartment initializations: - default = 1e-15; - CYTOPLASM = 1e-15; - compartment_0000004 = 1e-15; - - // Variable initializations: - rM_Vs = 0.76; - rM_KI = 1; - rM_n = 4; - rTL_ks = 0.38; - rP01_V1 = 3.2; - rP01_K1 = 2; - rP10_V2 = 1.58; - rP10_K2 = 2; - rP12_V3 = 5; - rP12_K3 = 2; - rP21_V4 = 2.5; - rP21_K4 = 2; - rP2n_k1 = 1.9; - rPn2_k2 = 1.3; - rmRNAd_Km = 0.5; - rmRNAd_Vm = 0.65; - rVd_Vd = 0.95; - rVd_Kd = 0.2; - - // Other declarations: - const default, CYTOPLASM, compartment_0000004; - - // Unit definitions: - unit substance = 1e-6 mole; - unit time_unit = 3600 second; - - // Display Names: - substance is "micromole (default)"; - time_unit is "heure (default)"; - compartment_0000004 is "NUCLEUS"; - M is "PER mRNA"; - P0 is "unphosphorylated PER"; - P1 is "monophosphorylated PER"; - P2 is "biphosphorylated PER"; - Pn is "nuclear PER"; - Pt is "total PER"; - rM is "transcription of PER"; - rTL is "translation of PER"; - rP01 is "first phosphorylation of PER"; - rP10 is "removal of the first PER phosphate"; - rP12 is "second phosphorylation of PER"; - rP21 is "removal of the second PER phosphate"; - rP2n is "translocation of PER to the nucleus"; - rPn2 is "translocation of PER to the cytoplasm"; - rmRNAd is "degradation of PER mRNA"; - rVd is "degradation of PER"; - - // CV terms: - CYTOPLASM identity "http://identifiers.org/go/GO:0005737" - compartment_0000004 identity "http://identifiers.org/go/GO:0005634" - M hypernym "http://identifiers.org/chebi/CHEBI:33699", - "http://identifiers.org/kegg.compound/C00046" - P0 hypernym "http://identifiers.org/uniprot/P07663" - P1 hypernym "http://identifiers.org/uniprot/P07663" - P2 hypernym "http://identifiers.org/uniprot/P07663" - Pn identity "http://identifiers.org/uniprot/P07663" - Pt identity "http://identifiers.org/uniprot/P07663" - rM hypernym "http://identifiers.org/go/GO:0006355", - "http://identifiers.org/go/GO:0009299" - rTL hypernym "http://identifiers.org/go/GO:0006412" - rP01 hypernym "http://identifiers.org/ec-code/2.7.11.1", - "http://identifiers.org/go/GO:0006468" - rP10 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0006470" - rP12 hypernym "http://identifiers.org/ec-code/2.7.11.1", - "http://identifiers.org/go/GO:0006468" - rP21 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0006470" - rP2n hypernym "http://identifiers.org/go/GO:0006606" - rPn2 hypernym "http://identifiers.org/go/GO:0006611" - rmRNAd hypernym "http://identifiers.org/go/GO:0006402" - rVd hypernym "http://identifiers.org/go/GO:0006402" -end - -Goldbeter1995 is "Goldbeter1995_CircClock" - -Goldbeter1995 model_entity_is "http://identifiers.org/biomodels.db/MODEL6617161845" -Goldbeter1995 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000016" -Goldbeter1995 description "http://identifiers.org/pubmed/8587874" -Goldbeter1995 identity "http://identifiers.org/kegg.pathway/dme04710" -Goldbeter1995 taxon "http://identifiers.org/taxonomy/7227" -Goldbeter1995 hypernym "http://identifiers.org/go/GO:0042752" diff --git a/BioModelsRAG/data/BIOMD0000000017.txt b/BioModelsRAG/data/BIOMD0000000017.txt deleted file mode 100644 index ac421146043a333f3259eed0ad754b68398f0b8c..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000017.txt +++ /dev/null @@ -1,218 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Hoefnagel2002_PyruvateBranches() - - // Compartments and Species: - compartment compartment_; - species $PO4 in compartment_; - substanceOnly species ADP in compartment_, NAD in compartment_, ATP in compartment_; - substanceOnly species NADH in compartment_, pyruvate in compartment_, $lactate in compartment_; - substanceOnly species CoA in compartment_, $halfglucose in compartment_; - substanceOnly species AcCoA in compartment_, AcP in compartment_, $Ac in compartment_; - substanceOnly species AcO in compartment_, $EtOH in compartment_, AcLac in compartment_; - substanceOnly species AcetoinIn in compartment_, $AcetoinOut in compartment_; - substanceOnly species $Butanediol in compartment_, $O2 in compartment_; - - // Reactions: - R1: ADP + NAD + $halfglucose => ATP + NADH + pyruvate; 2*R1_V_1*(halfglucose/(2*R1_Kglc_1))*(NAD/R1_Knad_1)*(ADP/R1_Kadp_1)/((1 + halfglucose/(2*R1_Kglc_1) + pyruvate/R1_Kpyr_1)*(1 + NAD/R1_Knad_1 + NADH/R1_Knadh_1)*(1 + ADP/R1_Kadp_1 + ATP/R1_Katp_1)); - R2: NADH + pyruvate => NAD + $lactate; R2_V_2*((pyruvate*NADH - lactate*NAD/R2_Keq_2)/(R2_Kpyr_2*R2_Knadh_2))/((1 + pyruvate/R2_Kpyr_2 + lactate/R2_Klac_2)*(1 + NADH/R2_Knadh_2 + NAD/R2_Knad_2)); - R3: NAD + pyruvate + CoA => NADH + AcCoA; R3_V_3*(pyruvate/R3_Kpyr_3)*(NAD/R3_Knad_3)*(CoA/R3_Kcoa_3)*(NAD/(NAD + R3_Ki_3*NADH))/((1 + pyruvate/R3_Kpyr_3)*(1 + NAD/R3_Knad_3 + NADH/R3_Knadh_3)*(1 + CoA/R3_Kcoa_3 + AcCoA/R3_Kaccoa_3)); - R4: AcCoA + $PO4 => CoA + AcP; R4_V_4*((AcCoA*PO4 - AcP*CoA/R4_Keq_4)/(R4_Kiaccoa_4*R4_Kpi_4))/(1 + AcCoA/R4_Kiaccoa_4 + PO4/R4_Kipi_4 + AcP/R4_Kiacp_4 + CoA/R4_Kicoa_4 + AcCoA*PO4/(R4_Kiaccoa_4*R4_Kpi_4) + AcP*CoA/(R4_Kacp_4*R4_Kicoa_4)); - R5: ADP + AcP => ATP + $Ac; R5_V_5*((AcP*ADP - Ac*ATP/R5_Keq_5)/(R5_Kadp_5*R5_Kacp_5))/((1 + AcP/R5_Kacp_5 + Ac/R5_Kac_5)*(1 + ADP/R5_Kadp_5 + ATP/R5_Katp_5)); - R6: NADH + AcCoA => NAD + CoA + AcO; R6_V_6*((AcCoA*NADH - CoA*NAD*AcO/R6_Keq_6)/(R6_Kaccoa_6*R6_Knadh_6))/((1 + NAD/R6_Knad_6 + NADH/R6_Knadh_6)*(1 + AcCoA/R6_Kaccoa_6 + CoA/R6_Kcoa_6)*(1 + AcO/R6_Kaco_6)); - R7: NADH + AcO => NAD + $EtOH; R7_V_7*((AcO*NADH - EtOH*NAD/R7_Keq_7)/(R7_Kaco_7*R7_Knadh_7))/((1 + NAD/R7_Knad_7 + NADH/R7_Knadh_7)*(1 + AcO/R7_Kaco_7 + EtOH/R7_Ketoh_7)); - R8: 2 pyruvate => AcLac; R8_V_8*(pyruvate/R8_Kpyr_8)*(1 - AcLac/(pyruvate*R8_Keq_8))*(pyruvate/R8_Kpyr_8 + AcLac/R8_Kaclac_8)^(R8_n_8 - 1)/(1 + (pyruvate/R8_Kpyr_8 + AcLac/R8_Kaclac_8)^R8_n_8); - R9: AcLac => AcetoinIn; R9_V_9*(AcLac/R9_Kaclac_9)/(1 + AcLac/R9_Kaclac_9 + AcetoinIn/R9_Kacet_9); - R10: AcetoinIn => $AcetoinOut; R10_V_10*(AcetoinIn/R10_Kacet_10)/(1 + AcetoinIn/R10_Kacet_10); - R11: NADH + AcetoinIn => NAD + $Butanediol; R11_V_11*((AcetoinIn*NADH - Butanediol*NAD/R11_Keq_11)/(R11_Kacet_11*R11_Knadh_11))/((1 + AcetoinIn/R11_Kacet_11 + Butanediol/R11_Kbut_11)*(1 + NADH/R11_Knadh_11 + NAD/R11_Knad_11)); - R12: ATP => ADP; R12_V_12*(ATP/(ADP*R12_Katp_12))^R12_n_12/(1 + (ATP/(ADP*R12_Katp_12))^R12_n_12); - R13: NADH + $O2 => NAD; R13_V_13*(NADH*O2/(R13_Knadh_13*R13_Ko_13))/((1 + NADH/R13_Knadh_13 + NAD/R13_Knad_13)*(1 + O2/R13_Ko_13)); - R14: AcLac => AcetoinIn; R14_k_14*AcLac; - - // Species initializations: - ADP = 4.9/compartment_; - NAD = 6.33/compartment_; - ATP = 0.1/compartment_; - NADH = 3.67/compartment_; - pyruvate = 1/compartment_; - lactate = 0.1/compartment_; - CoA = 1/compartment_; - halfglucose = 30/compartment_; - AcCoA = 0; - AcP = 0; - Ac = 1/compartment_; - AcO = 0; - EtOH = 1/compartment_; - AcLac = 0; - AcetoinIn = 0; - AcetoinOut = 0; - Butanediol = 0.01/compartment_; - O2 = 0.2/compartment_; - PO4 = 10/compartment_; - - // Compartment initializations: - compartment_ = 1; - - // Variable initializations: - R1_V_1 = 2397; - R1_Kglc_1 = 0.1; - R1_Knad_1 = 0.1412; - R1_Kadp_1 = 0.04699; - R1_Kpyr_1 = 2.5; - R1_Knadh_1 = 0.08999; - R1_Katp_1 = 0.01867; - R2_V_2 = 5118; - R2_Keq_2 = 21120.69; - R2_Kpyr_2 = 1.5; - R2_Knadh_2 = 0.08; - R2_Klac_2 = 100; - R2_Knad_2 = 2.4; - R3_V_3 = 259; - R3_Kpyr_3 = 1; - R3_Knad_3 = 0.4; - R3_Kcoa_3 = 0.014; - R3_Ki_3 = 46.4159; - R3_Knadh_3 = 0.1; - R3_Kaccoa_3 = 0.008; - R4_V_4 = 42; - R4_Keq_4 = 0.0065; - R4_Kiaccoa_4 = 0.2; - R4_Kpi_4 = 2.6; - R4_Kipi_4 = 2.6; - R4_Kiacp_4 = 0.2; - R4_Kicoa_4 = 0.029; - R4_Kacp_4 = 0.7; - R5_V_5 = 2700; - R5_Keq_5 = 174.217; - R5_Kadp_5 = 0.5; - R5_Kacp_5 = 0.16; - R5_Kac_5 = 7; - R5_Katp_5 = 0.07; - R6_V_6 = 97; - R6_Keq_6 = 1; - R6_Kaccoa_6 = 0.007; - R6_Knadh_6 = 0.025; - R6_Knad_6 = 0.08; - R6_Kcoa_6 = 0.008; - R6_Kaco_6 = 10; - R7_V_7 = 162; - R7_Keq_7 = 12354.9; - R7_Kaco_7 = 0.03; - R7_Knadh_7 = 0.05; - R7_Knad_7 = 0.08; - R7_Ketoh_7 = 1; - R8_V_8 = 600; - R8_Kpyr_8 = 50; - R8_Keq_8 = 9000000000000; - R8_Kaclac_8 = 100; - R8_n_8 = 2.4; - R9_V_9 = 106; - R9_Kaclac_9 = 10; - R9_Kacet_9 = 100; - R10_V_10 = 200; - R10_Kacet_10 = 5; - R11_V_11 = 105; - R11_Keq_11 = 1400; - R11_Kacet_11 = 0.06; - R11_Knadh_11 = 0.02; - R11_Kbut_11 = 2.6; - R11_Knad_11 = 0.16; - R12_V_12 = 900; - R12_Katp_12 = 6.196; - R12_n_12 = 2.58; - R13_V_13 = 118; - R13_Knadh_13 = 0.041; - R13_Ko_13 = 0.2; - R13_Knad_13 = 1; - R14_k_14 = 0.0003; - - // Other declarations: - const compartment_; - - // Unit definitions: - unit substance = 1e-3 mole; - unit time_unit = 60 second; - - // Display Names: - substance is "millimole (default)"; - time_unit is "minute (default)"; - - // CV terms: - ADP identity "http://identifiers.org/chebi/CHEBI:16761", - "http://identifiers.org/kegg.compound/C00008" - NAD identity "http://identifiers.org/chebi/CHEBI:15846", - "http://identifiers.org/kegg.compound/C00003" - ATP identity "http://identifiers.org/chebi/CHEBI:15422", - "http://identifiers.org/kegg.compound/C00002" - NADH identity "http://identifiers.org/chebi/CHEBI:16908", - "http://identifiers.org/kegg.compound/C00004" - pyruvate identity "http://identifiers.org/chebi/CHEBI:15361", - "http://identifiers.org/kegg.compound/C00022" - lactate identity "http://identifiers.org/chebi/CHEBI:24996", - "http://identifiers.org/kegg.compound/C00186" - CoA identity "http://identifiers.org/chebi/CHEBI:15346", - "http://identifiers.org/kegg.compound/C00010" - AcCoA identity "http://identifiers.org/chebi/CHEBI:15351", - "http://identifiers.org/kegg.compound/C00024" - AcP identity "http://identifiers.org/chebi/CHEBI:15350", - "http://identifiers.org/kegg.compound/C00227" - Ac identity "http://identifiers.org/chebi/CHEBI:30089", - "http://identifiers.org/kegg.compound/C00033" - AcO identity "http://identifiers.org/chebi/CHEBI:15343", - "http://identifiers.org/kegg.compound/C00084" - EtOH identity "http://identifiers.org/chebi/CHEBI:16236", - "http://identifiers.org/kegg.compound/C00469" - AcLac identity "http://identifiers.org/chebi/CHEBI:16444", - "http://identifiers.org/kegg.compound/C00900" - AcetoinIn identity "http://identifiers.org/chebi/CHEBI:15688", - "http://identifiers.org/kegg.compound/C00466" - AcetoinOut identity "http://identifiers.org/chebi/CHEBI:15688", - "http://identifiers.org/kegg.compound/C00466" - Butanediol version "http://identifiers.org/chebi/CHEBI:16812", - "http://identifiers.org/chebi/CHEBI:16982", - "http://identifiers.org/kegg.compound/C03046", - "http://identifiers.org/kegg.compound/C03044" - O2 identity "http://identifiers.org/chebi/CHEBI:15379", - "http://identifiers.org/kegg.compound/C00007" - PO4 identity "http://identifiers.org/chebi/CHEBI:18367", - "http://identifiers.org/kegg.compound/C00009" - R1 parthood "http://identifiers.org/kegg.pathway/map00010" - R2 version "http://identifiers.org/ec-code/1.1.1.27", - "http://identifiers.org/ec-code/1.1.1.28", - "http://identifiers.org/kegg.reaction/R00703", - "http://identifiers.org/kegg.reaction/R00704", - "http://identifiers.org/reactome/REACT_178" - R3 hypernym "http://identifiers.org/ec-code/1.2.1.51" - R3 identity "http://identifiers.org/kegg.reaction/R00209" - R4 hypernym "http://identifiers.org/ec-code/2.3.1.8" - R4 identity "http://identifiers.org/kegg.reaction/R00230" - R5 hypernym "http://identifiers.org/ec-code/2.7.2.1" - R5 identity "http://identifiers.org/kegg.reaction/R00315" - R6 hypernym "http://identifiers.org/ec-code/1.2.1.10" - R6 identity "http://identifiers.org/kegg.reaction/R00228" - R7 hypernym "http://identifiers.org/ec-code/1.1.1.1" - R7 identity "http://identifiers.org/kegg.reaction/R00754", - "http://identifiers.org/reactome/REACT_799" - R8 hypernym "http://identifiers.org/ec-code/2.2.1.6" - R8 identity "http://identifiers.org/kegg.reaction/R00006" - R9 identity "http://identifiers.org/kegg.reaction/R02947" - R9 hypernym "http://identifiers.org/ec-code/4.1.1.5" - R10 hypernym "http://identifiers.org/go/GO:0015562" - R11 version "http://identifiers.org/ec-code/1.1.1.4", - "http://identifiers.org/ec-code/1.1.1.76", - "http://identifiers.org/kegg.reaction/R02344", - "http://identifiers.org/kegg.reaction/R02946" - R12 hypernym "http://identifiers.org/go/GO:0016887" - R13 hypernym "http://identifiers.org/go/GO:0006116" -end - -Hoefnagel2002_PyruvateBranches is "Hoefnagel2002_PyruvateBranches" - -Hoefnagel2002_PyruvateBranches model_entity_is "http://identifiers.org/biomodels.db/MODEL6617235316" -Hoefnagel2002_PyruvateBranches model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000017" -Hoefnagel2002_PyruvateBranches description "http://identifiers.org/pubmed/11932446" -Hoefnagel2002_PyruvateBranches hypernym "http://identifiers.org/go/GO:0006090", - "http://identifiers.org/go/GO:0006089" -Hoefnagel2002_PyruvateBranches parthood "http://identifiers.org/kegg.pathway/map00620", - "http://identifiers.org/kegg.pathway/map00650" -Hoefnagel2002_PyruvateBranches taxon "http://identifiers.org/taxonomy/1358" -Hoefnagel2002_PyruvateBranches property "http://identifiers.org/mamo/MAMO_0000046" diff --git a/BioModelsRAG/data/BIOMD0000000018.txt b/BioModelsRAG/data/BIOMD0000000018.txt deleted file mode 100644 index 89c91df43f414cb8bc50b1a205de067855020bb6..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000018.txt +++ /dev/null @@ -1,341 +0,0 @@ -// Created by libAntimony v2.13.0 -model *MorrisonAllegra() - - // Compartments and Species: - compartment ext_, cell; - species FH2f in cell, $FH2b in cell, DHFRf in cell, $DHFRtot in cell, MTX1b in cell; - species MTX2b in cell, MTX3b in cell, MTX4b in cell, MTX5b in cell, FH4 in cell; - species CH2FH4 in cell, CH3FH4 in cell, CHOFH4 in cell, FFH2 in cell, HCHO in cell; - species FGAR in cell, AICAR in cell, MTX1 in cell, MTX2 in cell, MTX3 in cell; - species MTX4 in cell, MTX5 in cell, $EMTX in ext_, $dUMP in cell, $GAR in cell; - species $serine in cell, $formate in cell, $ATP in cell, $glutamine in cell; - species $glycine in cell, $NADP in cell, $NADPH in cell, $homocysteine in cell; - - // Assignment Rules: - FH2b := FH2f*DHFRf/Keq; - DHFRtot := FH2b + DHFRf + MTX1b + MTX2b + MTX3b + MTX4b + MTX5b; - - // Reactions: - SHMT: FH4 + $serine => CH2FH4; cell*(SHMT_Vm*(serine/SHMT_Km2/(1 + serine/SHMT_Km2))*(FH4/SHMT_Km1)/(1 + FH4/SHMT_Km1)); - SHMTr: CH2FH4 => FH4; cell*(SHMTr_Vm*(glycine/SHMTr_Km2/(1 + glycine/SHMTr_Km2))*(CH2FH4/SHMTr_Km1)/(1 + CH2FH4/SHMTr_Km1)); - HCHOtoCH2FH4: FH4 + HCHO => CH2FH4; cell*HCHOtoCH2FH4_hp*FH4*HCHO; - CH2FH4toHCHO: CH2FH4 => FH4 + HCHO; cell*CH2FH4toHCHO_hl*CH2FH4; - MTHFR: CH2FH4 + $NADPH => CH3FH4; cell*(MTHFR_Vm*CH2FH4*NADPH/(NADPH*CH2FH4 + CH2FH4*MTHFR_Km2 + (NADPH + MTHFR_Km2)*MTHFR_Km1*(1 + MTX1/MTHFR_Ki21 + MTX2/MTHFR_Ki22 + MTX3/MTHFR_Ki23 + MTX4/MTHFR_Ki24 + MTX5/MTHFR_Ki25 + FH2f/MTHFR_Ki1))); - MTR: CH3FH4 + $homocysteine => FH4; cell*(MTR_Vm*(homocysteine/MTR_Km2/(1 + homocysteine/MTR_Km2))*(CH3FH4/MTR_Km1)/(1 + CH3FH4/MTR_Km1)); - HCOOHtoCHOFH4: FH4 + $formate + $ATP => CHOFH4; cell*(HCOOHtoCHOFH4_Vm/((1 + HCOOHtoCHOFH4_Km1/FH4)*(1 + HCOOHtoCHOFH4_Km2/ATP)*(1 + HCOOHtoCHOFH4_Km3/formate))); - GARFT: CHOFH4 + $GAR => FGAR + FH4; cell*(GARFT_Vm*CHOFH4*GAR/(GAR*CHOFH4 + CHOFH4*GARFT_Km2 + (GAR + GARFT_Km2)*GARFT_Km1*(1 + MTX1/GARFT_Ki21 + MTX2/GARFT_Ki22 + MTX3/GARFT_Ki23 + MTX4/GARFT_Ki24 + MTX5/GARFT_Ki25 + FH2f/GARFT_Ki1 + FFH2/GARFT_Ki1f))); - ATIC7: CHOFH4 + AICAR => FH4; cell*(ATIC7_Vm*CHOFH4*AICAR/(AICAR*CHOFH4 + CHOFH4*ATIC7_Km2 + (AICAR + ATIC7_Km2)*ATIC7_Km1*(1 + MTX1/ATIC7_Ki21 + MTX2/ATIC7_Ki22 + MTX3/ATIC7_Ki23 + MTX4/ATIC7_Ki24 + MTX5/ATIC7_Ki25 + FH2f/ATIC7_Ki1 + FFH2/ATIC7_Ki1f))); - MTHFD: CH2FH4 + $NADP => CHOFH4; cell*MTHFD_Vm*(CH2FH4/MTHFD_Km1/(1 + CH2FH4/MTHFD_Km1))*(NADP/MTHFD_Km2/(1 + NADP/MTHFD_Km2)); - TYMS: CH2FH4 + $dUMP => FH2f; cell*(TYMS_Vm*CH2FH4*dUMP/(dUMP*CH2FH4*(1 + MTX1/TYMS_Ki21 + MTX2/TYMS_Ki22 + MTX3/TYMS_Ki23 + MTX4/TYMS_Ki24 + MTX5/TYMS_Ki25 + FH2f/TYMS_Ki1) + TYMS_Km1*dUMP*((FFH2/TYMS_Ki1f)*(MTX1/TYMS_Ki21) + (1 + FFH2/TYMS_Ki1f)*(1 + MTX2/TYMS_Ki22 + MTX3/TYMS_Ki23 + MTX4/TYMS_Ki24 + MTX5/TYMS_Ki25 + FH2f/TYMS_Ki1)) + TYMS_Km1*TYMS_Km2*(1 + MTX2/TYMS_Ki22 + MTX3/TYMS_Ki23 + MTX4/TYMS_Ki24 + MTX5/TYMS_Ki25 + FH2f/TYMS_Ki1))); - DHFReductase: FH2f => FH4; cell*DHFReductase_kter*FH2b; - FFH2syn: FH2f => FFH2; cell*FFH2syn_Vm*FH2f; - ATIC12: FFH2 + AICAR => FH2f; cell*(ATIC12_Vm*FFH2*AICAR/(AICAR*FFH2 + FFH2*ATIC12_Km2 + (AICAR + ATIC12_Km2)*ATIC12_Km1*(1 + MTX1/ATIC12_Ki21 + MTX2/ATIC12_Ki22 + MTX3/ATIC12_Ki23 + MTX4/ATIC12_Ki24 + MTX5/ATIC12_Ki25 + FH2f/ATIC12_Ki1 + FFH2/ATIC12_Ki1f))); - AICARsyn: FGAR => AICAR; cell*AICARsyn_Vm*(glutamine/AICARsyn_Km1/(1 + glutamine/AICARsyn_Km1))*(FGAR/AICARsyn_Km2/(1 + FGAR/AICARsyn_Km2)); - FPGS12: MTX1 => MTX2; cell*FPGS12_Vm*MTX1; - FPGS23: MTX2 => MTX3; cell*FPGS23_Vm*MTX2; - FPGS34: MTX3 => MTX4; cell*FPGS34_Vm*MTX3; - FPGS45: MTX4 => MTX5; cell*FPGS45_Vm*MTX4; - GGH21: MTX2 => MTX1; cell*GGH21_Vm*MTX2; - GGH32: MTX3 => MTX2; cell*GGH32_Vm*MTX3; - GGH43: MTX4 => MTX3; cell*GGH43_Vm*MTX4; - GGH54: MTX5 => MTX4; cell*GGH54_Vm*MTX5; - RFC: $EMTX => MTX1; ext_*(RFC_Vm*EMTX/(RFC_Km + EMTX)); - MTX1export: MTX1 => ; cell*MTX1export_Vm*MTX1; - MTX2export: MTX2 => ; cell*MTX2export_Vm*MTX2; - MTX3export: MTX3 => ; cell*MTX3export_Vm*MTX3; - MTX4export: MTX4 => ; cell*MTX4export_Vm*MTX4; - MTX5export: MTX5 => ; cell*MTX5export_Vm*MTX5; - MTX1on: MTX1 + DHFRf => MTX1b; cell*MTX1on_Vm*DHFRf*MTX1; - MTX2on: MTX2 + DHFRf => MTX2b; cell*MTX2on_Vm*DHFRf*MTX2; - MTX3on: MTX3 + DHFRf => MTX3b; cell*MTX3on_Vm*DHFRf*MTX3; - MTX4on: MTX4 + DHFRf => MTX4b; cell*MTX4on_Vm*DHFRf*MTX4; - MTX5on: MTX5 + DHFRf => MTX5b; cell*MTX5on_Vm*DHFRf*MTX5; - MTX1off: MTX1b => MTX1 + DHFRf; cell*MTX1off_Vm*MTX1b; - MTX2off: MTX2b => MTX2 + DHFRf; cell*MTX2off_Vm*MTX2b; - MTX3off: MTX3b => MTX3 + DHFRf; cell*MTX3off_Vm*MTX3b; - MTX4off: MTX4b => MTX4 + DHFRf; cell*MTX4off_Vm*MTX4b; - MTX5off: MTX5b => MTX5 + DHFRf; cell*MTX5off_Vm*MTX5b; - DHFRfsyn: => DHFRf; cell*(DHFRfsyn_k0 + DHFRfsyn_k1*EMTX); - DHFRdeg: DHFRf => ; DHFRdeg_Vm*cell*(DHFRf + FH2b); - FH2bdeg: => FH2f; cell*FH2bdeg_Vm*FH2b; - MTX1deg: MTX1b => MTX1; cell*MTX1deg_Vm*MTX1b; - MTX2deg: MTX2b => MTX2; cell*MTX2deg_Vm*MTX2b; - MTX3deg: MTX3b => MTX3; cell*MTX3deg_Vm*MTX3b; - MTX4deg: MTX4b => MTX4; cell*MTX4deg_Vm*MTX4b; - MTX5deg: MTX5b => MTX5; cell*MTX5deg_Vm*MTX5b; - - // Species initializations: - FH2f = 0.0012; - DHFRf = 0.64; - MTX1b = 0; - MTX2b = 0; - MTX3b = 0; - MTX4b = 0; - MTX5b = 0; - FH4 = 0.46; - CH2FH4 = 0.26; - CH3FH4 = 1.63; - CHOFH4 = 1; - FFH2 = 0.000332; - HCHO = 0.0074; - FGAR = 16.49; - AICAR = 3.695; - MTX1 = 0; - MTX2 = 0; - MTX3 = 0; - MTX4 = 0; - MTX5 = 0; - EMTX = 0; - dUMP = 20.76; - GAR = 689.6; - serine = 123.3; - formate = 500; - ATP = 2980; - glutamine = 7170; - glycine = 1600; - NADP = 6.73; - NADPH = 294; - homocysteine = 10; - - // Compartment initializations: - ext_ = 1; - cell = 1; - - // Variable initializations: - Keq = 0.32; - SHMT_Vm = 18330; - SHMT_Km1 = 1.7; - SHMT_Km2 = 210; - SHMTr_Vm = 12200000; - SHMTr_Km1 = 3200; - SHMTr_Km2 = 10000; - HCHOtoCH2FH4_hp = 23.2; - CH2FH4toHCHO_hl = 0.3; - MTHFR_Vm = 224.8; - MTHFR_Km1 = 50; - MTHFR_Km2 = 50; - MTHFR_Ki1 = 0.4; - MTHFR_Ki21 = 59; - MTHFR_Ki22 = 21.3; - MTHFR_Ki23 = 7.68; - MTHFR_Ki24 = 2.77; - MTHFR_Ki25 = 1; - MTR_Vm = 22600; - MTR_Km1 = 125; - MTR_Km2 = 2900; - HCOOHtoCHOFH4_Vm = 3600; - HCOOHtoCHOFH4_Km1 = 230; - HCOOHtoCHOFH4_Km2 = 56; - HCOOHtoCHOFH4_Km3 = 1600; - GARFT_Vm = 4126; - GARFT_Km1 = 4.9; - GARFT_Km2 = 52; - GARFT_Ki1 = 5; - GARFT_Ki1f = 1; - GARFT_Ki21 = 84; - GARFT_Ki22 = 60; - GARFT_Ki23 = 43; - GARFT_Ki24 = 31; - GARFT_Ki25 = 22; - ATIC7_Vm = 31675; - ATIC7_Km1 = 5.5; - ATIC7_Km2 = 24; - ATIC7_Ki1 = 2.89; - ATIC7_Ki1f = 5.3; - ATIC7_Ki21 = 40; - ATIC7_Ki22 = 31.5; - ATIC7_Ki23 = 2.33; - ATIC7_Ki24 = 3.61; - ATIC7_Ki25 = 5.89; - MTHFD_Vm = 68500; - MTHFD_Km1 = 3; - MTHFD_Km2 = 21.8; - TYMS_Vm = 58; - TYMS_Km1 = 2.5; - TYMS_Km2 = 1.8; - TYMS_Ki1 = 3; - TYMS_Ki1f = 1.6; - TYMS_Ki21 = 13; - TYMS_Ki22 = 0.08; - TYMS_Ki23 = 0.07; - TYMS_Ki24 = 0.065; - TYMS_Ki25 = 0.047; - DHFReductase_kter = 2109.4; - FFH2syn_Vm = 65; - ATIC12_Vm = 9503; - ATIC12_Km1 = 5.3; - ATIC12_Km2 = 24; - ATIC12_Ki1 = 2.89; - ATIC12_Ki1f = 5.5; - ATIC12_Ki21 = 40; - ATIC12_Ki22 = 31.5; - ATIC12_Ki23 = 2.33; - ATIC12_Ki24 = 3.61; - ATIC12_Ki25 = 5.89; - AICARsyn_Vm = 4656; - AICARsyn_Km1 = 100; - AICARsyn_Km2 = 100; - FPGS12_Vm = 0.129; - FPGS23_Vm = 0.369; - FPGS34_Vm = 0.118; - FPGS45_Vm = 0.185; - GGH21_Vm = 0.195; - GGH32_Vm = 0.025; - GGH43_Vm = 0.031; - GGH54_Vm = 0.191; - RFC_Vm = 82.2; - RFC_Km = 8.2; - MTX1export_Vm = 4.65; - MTX2export_Vm = 0; - MTX3export_Vm = 0.063; - MTX4export_Vm = 0.063; - MTX5export_Vm = 0.063; - MTX1on_Vm = 23100; - MTX2on_Vm = 44300; - MTX3on_Vm = 85100; - MTX4on_Vm = 163000; - MTX5on_Vm = 314000; - MTX1off_Vm = 0.42; - MTX2off_Vm = 0.42; - MTX3off_Vm = 0.42; - MTX4off_Vm = 0.42; - MTX5off_Vm = 0.42; - DHFRfsyn_k0 = 0.0192; - DHFRfsyn_k1 = 0.04416; - DHFRdeg_Vm = 0.03; - FH2bdeg_Vm = 0.03; - MTX1deg_Vm = 0.03; - MTX2deg_Vm = 0.03; - MTX3deg_Vm = 0.03; - MTX4deg_Vm = 0.03; - MTX5deg_Vm = 0.03; - - // Other declarations: - const ext_, cell, Keq; - - // Unit definitions: - unit substance = 1e-6 mole; - unit time_unit = 3600 second; - - // Display Names: - substance is "micromole (new default)"; - time_unit is "heure (new default)"; - FH2f is "dihydrofolate free"; - FH2b is "dihydrofolate bound"; - DHFRf is "dihydrofolate reductase free"; - DHFRtot is "dihydrofolate reductase total"; - FH4 is "tetrahydrofolate"; - CH2FH4 is "5,10-methylene-tetrahydrofolate"; - CH3FH4 is "5-methyl-tetrahydrofolate"; - CHOFH4 is "10-formyl-tetrahydrofolate"; - FFH2 is "10-formyl-dihydrofolate"; - - // CV terms: - ext_ identity "http://identifiers.org/go/GO:0005615" - cell identity "http://identifiers.org/go/GO:0005623" - FH2f hypernym "http://identifiers.org/chebi/CHEBI:15633", - "http://identifiers.org/kegg.compound/C00415" - FH2b hypernym "http://identifiers.org/chebi/CHEBI:15633", - "http://identifiers.org/kegg.compound/C00415" - DHFRf identity "http://identifiers.org/uniprot/P00374" - DHFRtot identity "http://identifiers.org/uniprot/P00374" - MTX1b identity "http://identifiers.org/kegg.compound/C01937" - MTX2b identity "http://identifiers.org/kegg.compound/C01937" - MTX3b identity "http://identifiers.org/kegg.compound/C01937" - MTX4b identity "http://identifiers.org/kegg.compound/C01937" - MTX5b identity "http://identifiers.org/kegg.compound/C01937" - FH4 identity "http://identifiers.org/chebi/CHEBI:20506", - "http://identifiers.org/kegg.compound/C00101" - CH2FH4 identity "http://identifiers.org/chebi/CHEBI:15636", - "http://identifiers.org/kegg.compound/C00143" - CH3FH4 identity "http://identifiers.org/chebi/CHEBI:15641", - "http://identifiers.org/kegg.compound/C00440" - CHOFH4 identity "http://identifiers.org/chebi/CHEBI:15637", - "http://identifiers.org/kegg.compound/C00234" - FFH2 identity "http://identifiers.org/chebi/CHEBI:15634", - "http://identifiers.org/kegg.compound/C03204" - HCHO identity "http://identifiers.org/chebi/CHEBI:16842", - "http://identifiers.org/kegg.compound/C00067" - FGAR identity "http://identifiers.org/kegg.compound/C04376" - AICAR identity "http://identifiers.org/chebi/CHEBI:18406", - "http://identifiers.org/kegg.compound/C04677" - MTX1 identity "http://identifiers.org/kegg.compound/C01937" - MTX2 identity "http://identifiers.org/kegg.compound/C01937" - MTX3 identity "http://identifiers.org/kegg.compound/C01937" - MTX4 identity "http://identifiers.org/kegg.compound/C01937" - MTX5 identity "http://identifiers.org/kegg.compound/C01937" - EMTX identity "http://identifiers.org/kegg.compound/C01937" - dUMP identity "http://identifiers.org/chebi/CHEBI:17622", - "http://identifiers.org/kegg.compound/C00365" - GAR identity "http://identifiers.org/kegg.compound/C03838" - serine identity "http://identifiers.org/chebi/CHEBI:17115", - "http://identifiers.org/kegg.compound/C00065" - formate identity "http://identifiers.org/chebi/CHEBI:15740", - "http://identifiers.org/kegg.compound/C00058" - ATP identity "http://identifiers.org/chebi/CHEBI:15422", - "http://identifiers.org/kegg.compound/C00002" - glutamine identity "http://identifiers.org/chebi/CHEBI:18050", - "http://identifiers.org/kegg.compound/C00064" - glycine identity "http://identifiers.org/chebi/CHEBI:15428", - "http://identifiers.org/kegg.compound/C00037" - NADP identity "http://identifiers.org/chebi/CHEBI:18009", - "http://identifiers.org/kegg.compound/C00006" - NADPH identity "http://identifiers.org/chebi/CHEBI:16474", - "http://identifiers.org/kegg.compound/C00005" - homocysteine identity "http://identifiers.org/chebi/CHEBI:17230", - "http://identifiers.org/kegg.compound/C05330" - SHMT identity "http://identifiers.org/kegg.reaction/R00945" - SHMT hypernym "http://identifiers.org/ec-code/2.1.2.1" - SHMTr identity "http://identifiers.org/kegg.reaction/R00945" - SHMTr hypernym "http://identifiers.org/ec-code/2.1.2.1" - MTHFR identity "http://identifiers.org/kegg.reaction/R01224" - MTHFR hypernym "http://identifiers.org/ec-code/1.5.1.20" - MTR identity "http://identifiers.org/kegg.reaction/R00946" - MTR hypernym "http://identifiers.org/ec-code/2.1.1.13" - HCOOHtoCHOFH4 identity "http://identifiers.org/kegg.reaction/R00943" - HCOOHtoCHOFH4 hypernym "http://identifiers.org/ec-code/6.3.4.3" - GARFT identity "http://identifiers.org/kegg.reaction/R04325", - "http://identifiers.org/reactome/REACT_1509" - GARFT hypernym "http://identifiers.org/ec-code/2.1.2.2" - ATIC7 identity "http://identifiers.org/kegg.reaction/R04560", - "http://identifiers.org/reactome/REACT_812" - ATIC7 hypernym "http://identifiers.org/ec-code/2.1.2.3" - MTHFD part "http://identifiers.org/ec-code/1.5.1.5", - "http://identifiers.org/ec-code/6.3.4.3", - "http://identifiers.org/kegg.reaction/R01220", - "http://identifiers.org/kegg.reaction/R01655" - TYMS identity "http://identifiers.org/kegg.reaction/R02101" - TYMS hypernym "http://identifiers.org/ec-code/2.1.1.45" - DHFReductase identity "http://identifiers.org/kegg.reaction/R00939" - DHFReductase hypernym "http://identifiers.org/ec-code/1.5.1.3" - FFH2syn identity "http://identifiers.org/kegg.reaction/R02238" - FFH2syn hypernym "http://identifiers.org/ec-code/6.3.4.17" - ATIC12 hypernym "http://identifiers.org/ec-code/2.1.2.3" - ATIC12 identity "http://identifiers.org/kegg.reaction/R04560" - AICARsyn hypernym "http://identifiers.org/ec-code/6.3.5.3" - FPGS12 hypernym "http://identifiers.org/ec-code/6.3.2.17" - FPGS23 hypernym "http://identifiers.org/ec-code/6.3.2.17" - FPGS34 hypernym "http://identifiers.org/ec-code/6.3.2.17" - FPGS45 hypernym "http://identifiers.org/ec-code/6.3.2.17" - GGH21 hypernym "http://identifiers.org/ec-code/3.4.19.9" - GGH32 hypernym "http://identifiers.org/ec-code/3.4.19.9" - GGH43 identity "http://identifiers.org/ec-code/3.4.19.9" - GGH54 identity "http://identifiers.org/ec-code/3.4.19.9" - RFC identity "http://identifiers.org/go/GO:0008517" - MTX1export identity "http://identifiers.org/go/GO:0008517" - MTX2export identity "http://identifiers.org/go/GO:0008517" - MTX3export identity "http://identifiers.org/go/GO:0008517" - MTX4export hypernym "http://identifiers.org/go/GO:0008517" - MTX5export hypernym "http://identifiers.org/go/GO:0008517" -end - -MorrisonAllegra is "Morrison1989 - Folate Cycle" - -MorrisonAllegra model_entity_is "http://identifiers.org/biomodels.db/MODEL6617317313" -MorrisonAllegra model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000018" -MorrisonAllegra description "http://identifiers.org/pubmed/2732237" -MorrisonAllegra taxon "http://identifiers.org/taxonomy/9606" -MorrisonAllegra part "http://identifiers.org/kegg.pathway/map00670", - "http://identifiers.org/kegg.pathway/map00790" -MorrisonAllegra hypernym "http://identifiers.org/go/GO:0046655" -MorrisonAllegra property "http://identifiers.org/doid/DOID:1612" diff --git a/BioModelsRAG/data/BIOMD0000000019.txt b/BioModelsRAG/data/BIOMD0000000019.txt deleted file mode 100644 index f53a7be43ac759da86a50cffba44bf63bfeeea59..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000019.txt +++ /dev/null @@ -1,652 +0,0 @@ -// Created by libAntimony v2.13.0 -model *BIOMD0000000019() - - // Compartments and Species: - compartment c1, c2, c3; - substanceOnly species $x1 in c1, x2 in c1, x3 in c2, x4 in c2, x5 in c2; - substanceOnly species x6 in c2, x7 in c2, x8 in c2, x9 in c2, x10 in c2; - substanceOnly species x11 in c2, x12 in c2, x13 in c3, x14 in c2, x15 in c3; - substanceOnly species x16 in c2, x17 in c2, x18 in c2, x19 in c2, x20 in c2; - substanceOnly species x21 in c2, x22 in c2, x23 in c2, x24 in c2, x25 in c2; - substanceOnly species x26 in c2, x27 in c2, x28 in c2, x29 in c2, x30 in c2; - substanceOnly species x31 in c2, x32 in c2, x33 in c2, x34 in c2, x35 in c2; - substanceOnly species x36 in c2, x37 in c2, x38 in c2, x39 in c2, x40 in c2; - substanceOnly species x41 in c2, x42 in c2, x43 in c2, x44 in c2, x45 in c2; - substanceOnly species x46 in c2, x47 in c2, x48 in c2, x49 in c2, x50 in c2; - substanceOnly species x51 in c2, x52 in c2, x53 in c2, x54 in c2, x55 in c2; - substanceOnly species x56 in c2, x57 in c2, x58 in c2, x59 in c2, x60 in c2; - substanceOnly species x61 in c2, x62 in c2, x63 in c2, x64 in c2, x65 in c2; - substanceOnly species x66 in c2, x67 in c2, x68 in c2, x69 in c2, x70 in c2; - substanceOnly species x71 in c2, x72 in c2, x73 in c2, x74 in c2, x75 in c2; - substanceOnly species x76 in c2, x77 in c2, x78 in c2, x79 in c2, x80 in c2; - substanceOnly species x81 in c2, x82 in c2, x83 in c2, x84 in c2, x85 in c2; - substanceOnly species x86 in c2, x87 in c2, x88 in c2, x89 in c2, x90 in c2; - substanceOnly species x91 in c2, x92 in c2, x93 in c2, x94 in c2, $Raf_act in c2; - substanceOnly species $Ras_GTP in c2, $MEK_PP in c2, $ERK_PP in c2, $SHC_P_t in c2; - substanceOnly species $EGF_EGFR_act in c2; - - // Assignment Rules: - Raf_act := x45 + x46 + x48 + x50 + x72 + x73 + x74 + x76; - Ras_GTP := x42 + x28 + x70 + x69; - MEK_PP := x51 + x77; - ERK_PP := x59 + x83; - SHC_P_t := x33 + x34 + x35 + x36 + x37 + x38 + x39 + x40 + x91 + x92 + x93 + x94 + x64 + x65 + x66 + x67 + x68; - EGF_EGFR_act := x5 + x7 + x15 + x23 + x25 + x27 + x29 + x32 + x33 + x34 + x35 + x36 + x37 + x88 + x89 + x90 + x91 + x92 + x93 + x94 + x8 + x11 + x17 + x18 + x19 + x20 + x21 + x63 + x64 + x65 + x66 + x67 + x68; - k5 := piecewise(1.55, C < 3100, 0.2, C > 100000, C*-1.35e-5 + 1.55); - C := RT/(kr1/(k1*x1) + 1); - - // Reactions: - v1: $x1 + x2 -> x3; k1*x1*x2 - kr1*x3; - v2: 2 x3 -> x4; k2*x3*x3 - kr2*x4; - v3: x4 -> x5; k3*x4 - kr3*x5; - v4: x23 + x12 -> x7; k4*x23*x12 - kr4*x7; - v5: x7 -> x18 + x9; k5*x7; - v6: x2 -> x6; k6*x2 - kr6*x6; - v7: x5 => x8; k7*x5; - v8: x5 + x14 -> x15; k8*x5*x14 - kr8*x15; - v9: x23 => x18; k7*x23; - v10: x6 + x16 -> x10; k10*x6*x16 - kr10*x10; - v11: 2 x10 -> x11; k2*x10*x10 - kr2*x11; - v12: x11 -> x8; k3*x11 - kr3*x8; - v13: => x2; k13; - v14: x8 + x14 -> x17; k14*x8*x14 - kr14*x17; - v15: x9 => x12; k15*x9; - v16: x22 + x15 -> x23; k16*x22*x15 - kr16*x23; - v17: x24 + x23 -> x25; k17*x24*x23 - kr17*x25; - v18: x26 + x25 -> x27; k18*x26*x25 - kr18*x27; - v19: x27 -> x28 + x25; k19*x27 - kr19*x28*x25; - v20: x25 + x43 -> x29; k20*x25*x43 - kr20*x29; - v21: x29 -> x25 + x26; k21*x29 - kr21*x25*x26; - v22: x31 + x15 -> x32; k22*x31*x15 - kr22*x32; - v23: x32 -> x33; k23*x32 - kr23*x33; - v24: x22 + x33 -> x34; k24*x22*x33 - kr24*x34; - v25: x24 + x34 -> x35; k25*x24*x34 - kr25*x35; - v26: x26 + x35 -> x36; k18*x26*x35 - kr18*x36; - v27: x36 -> x35 + x28; k19*x36 - kr19*x35*x28; - v28: x28 + x41 -> x42; k28*x28*x41 - kr28*x42; - v29: x42 -> x43 + x45; k29*x42 - kr29*x43*x45; - v30: x35 + x43 -> x37; k20*x35*x43 - kr20*x37; - v31: x37 -> x35 + x26; k21*x37 - kr21*x35*x26; - v32: x35 -> x15 + x38; k32*x35 - kr32*x15*x38; - v33: x38 -> x40 + x30; k33*x38 - kr33*x40*x30; - v34: x25 -> x15 + x30; k34*x25 - kr34*x15*x30; - v35: x30 -> x24 + x22; k35*x30 - kr35*x24*x22; - v36: x40 => x31; Vm36*x40/(Km36 + x40); - v37: x33 -> x15 + x40; k37*x33 - kr37*x15*x40; - v38: x22 + x40 -> x39; k24*x22*x40 - kr24*x39; - v39: x34 -> x15 + x39; k37*x34 - kr37*x15*x39; - v40: x24 + x39 -> x38; k40*x24*x39 - kr40*x38; - v41: x30 + x33 -> x35; k41*x30*x33 - kr41*x35; - v42: x44 + x45 -> x46; k42*x44*x45 - kr42*x46; - v43: x46 -> x41 + x44; k43*x46; - v44: x47 + x45 -> x48; k44*x47*x45 - kr44*x48; - v45: x48 -> x49 + x45; k45*x48; - v46: x49 + x45 -> x50; k44*x49*x45 - kr44*x50; - v47: x50 -> x51 + x45; k47*x50; - v48: x51 + x53 -> x52; k48*x51*x53 - kr48*x52; - v49: x52 -> x49 + x53; k49*x52; - v50: x53 + x49 -> x54; k50*x53*x49 - kr50*x54; - v51: x54 -> x47 + x53; k49*x54; - v52: x55 + x51 -> x56; k52*x55*x51 - kr52*x56; - v53: x56 -> x51 + x57; k53*x56; - v54: x51 + x57 -> x58; k52*x51*x57 - kr52*x58; - v55: x58 -> x59 + x51; k55*x58; - v56: x59 + x60 -> x61; k56*x59*x60 - kr56*x61; - v57: x61 -> x57 + x60; k57*x61; - v58: x60 + x57 -> x62; k58*x60*x57 - kr58*x62; - v59: x62 -> x55 + x60; k59*x62; - v60: x6 => x86; k60*x6; - v61: x16 => x13; k61*x16; - v62: x8 => x87; k60*x8; - v63: x17 + x22 -> x18; k16*x17*x22 - kr16*x18; - v64: x24 + x18 -> x19; k17*x24*x18 - kr17*x19; - v65: x26 + x19 -> x20; k18*x26*x19 - kr18*x20; - v66: x20 -> x69 + x19; k19*x20 - kr19*x69*x19; - v67: x71 + x19 -> x21; k20*x71*x19 - kr20*x21; - v68: x21 -> x19 + x26; k21*x21 - kr21*x19*x26; - v69: x31 + x17 -> x63; k22*x31*x17 - kr22*x63; - v70: x63 -> x64; k23*x63 - kr23*x64; - v71: x22 + x64 -> x65; k24*x22*x64 - kr24*x65; - v72: x24 + x65 -> x66; k25*x24*x65 - kr25*x66; - v73: x26 + x66 -> x67; k18*x26*x66 - kr18*x67; - v74: x67 -> x66 + x69; k19*x67 - kr19*x66*x69; - v75: x69 + x41 -> x70; k28*x69*x41 - kr28*x70; - v76: x70 -> x71 + x72; k29*x70 - kr29*x71*x72; - v77: x71 + x66 -> x68; k20*x71*x66 - kr20*x68; - v78: x68 -> x66 + x26; k21*x68 - kr21*x66*x26; - v79: x66 -> x17 + x38; k32*x66 - kr32*x17*x38; - v80: x19 -> x17 + x30; k34*x19 - kr34*x17*x30; - v81: x64 -> x17 + x40; k37*x64 - kr37*x17*x40; - v82: x65 -> x17 + x39; k37*x65 - kr37*x17*x39; - v83: x30 + x64 -> x66; k41*x30*x64 - kr41*x66; - v84: x44 + x72 -> x73; k42*x44*x72 - kr42*x73; - v85: x73 -> x41 + x44; k43*x73; - v86: x47 + x72 -> x74; k44*x47*x72 - kr44*x74; - v87: x74 -> x75 + x72; k45*x74; - v88: x72 + x75 -> x76; k44*x72*x75 - kr44*x76; - v89: x76 -> x72 + x77; k47*x76; - v90: x77 + x53 -> x78; k48*x77*x53 - kr48*x78; - v91: x78 -> x75 + x53; k49*x78; - v92: x53 + x75 -> x79; k50*x53*x75 - kr50*x79; - v93: x79 -> x47 + x53; k49*x79; - v94: x55 + x77 -> x80; k52*x55*x77 - kr52*x80; - v95: x80 -> x81 + x77; k53*x80; - v96: x77 + x81 -> x82; k52*x77*x81 - kr52*x82; - v97: x82 -> x83 + x77; k55*x82; - v98: x83 + x60 -> x84; k56*x83*x60 - kr56*x84; - v99: x84 -> x81 + x60; k57*x84; - v100: x60 + x81 -> x85; k58*x60*x81 - kr58*x85; - v101: x85 -> x55 + x60; k59*x85; - v102: x15 -> x17; k6*x15 - kr6*x17; - v103: x32 -> x63; k6*x32 - kr6*x63; - v104: x33 -> x64; k6*x33 - kr6*x64; - v105: x25 -> x19; k6*x25 - kr6*x19; - v106: x25 + x12 -> x88; k4*x25*x12 - kr4*x88; - v107: x88 -> x9 + x19; k5*x88; - v108: x27 -> x20; k6*x27 - kr6*x20; - v109: x27 + x12 -> x89; k4*x27*x12 - kr4*x89; - v110: x89 -> x9 + x20; k5*x89; - v111: x29 -> x21; k6*x29 - kr6*x21; - v112: x29 + x12 -> x90; k4*x29*x12 - kr4*x90; - v113: x90 -> x9 + x21; k5*x90; - v114: x34 -> x65; k6*x34 - kr6*x65; - v115: x34 + x12 -> x91; k4*x34*x12 - kr4*x91; - v116: x91 -> x9 + x65; k5*x91; - v117: x35 -> x66; k6*x35 - kr6*x66; - v118: x35 + x12 -> x92; k4*x35*x12 - kr4*x92; - v119: x92 -> x9 + x66; k5*x92; - v120: x36 -> x67; k6*x36 - kr6*x67; - v121: x36 + x12 -> x93; k4*x36*x12 - kr4*x93; - v122: x93 -> x9 + x67; k5*x93; - v123: x37 -> x68; k6*x37 - kr6*x68; - v124: x37 + x12 -> x94; k4*x37*x12 - kr4*x94; - v125: x94 -> x68 + x9; k5*x94; - - // Species initializations: - x1 = 4962/c1; - x2 = 50000/c1; - x3 = 0; - x4 = 0; - x5 = 0; - x6 = 0; - x7 = 0; - x8 = 0; - x9 = 0; - x10 = 0; - x11 = 0; - x12 = 81000/c2; - x13 = 0; - x14 = 12000/c2; - x15 = 0; - x16 = 0; - x17 = 0; - x18 = 0; - x19 = 0; - x20 = 0; - x21 = 0; - x22 = 11000/c2; - x23 = 0; - x24 = 26300/c2; - x25 = 0; - x26 = 72000/c2; - x27 = 0; - x28 = 0; - x29 = 0; - x30 = 40000/c2; - x31 = 101000/c2; - x32 = 0; - x33 = 0; - x34 = 0; - x35 = 0; - x36 = 0; - x37 = 0; - x38 = 0; - x39 = 0; - x40 = 0; - x41 = 40000/c2; - x42 = 0; - x43 = 0; - x44 = 40000/c2; - x45 = 0; - x46 = 0; - x47 = 22000000/c2; - x48 = 0; - x49 = 0; - x50 = 0; - x51 = 0; - x52 = 0; - x53 = 40000/c2; - x54 = 0; - x55 = 21000000/c2; - x56 = 0; - x57 = 0; - x58 = 0; - x59 = 0; - x60 = 10000000/c2; - x61 = 0; - x62 = 0; - x63 = 0; - x64 = 0; - x65 = 0; - x66 = 0; - x67 = 0; - x68 = 0; - x69 = 0; - x70 = 0; - x71 = 0; - x72 = 0; - x73 = 0; - x74 = 0; - x75 = 0; - x76 = 0; - x77 = 0; - x78 = 0; - x79 = 0; - x80 = 0; - x81 = 0; - x82 = 0; - x83 = 0; - x84 = 0; - x85 = 0; - x86 = 0; - x87 = 0; - x88 = 0; - x89 = 0; - x90 = 0; - x91 = 0; - x92 = 0; - x93 = 0; - x94 = 0; - - // Compartment initializations: - c1 = 1; - c2 = 1; - c3 = 4.3e-06; - - // Variable initializations: - k1 = 0.003; - k1 has pipmin; - kr1 = 0.228; - kr1 has pmin; - kr2 = 6; - kr2 has pmin; - k2 = 0.001; - k2 has pipmin; - k3 = 60; - k3 has pmin; - kr3 = 0.6; - kr3 has pmin; - k4 = 1.038e-05; - k4 has pipmin; - kr4 = 0.0996; - kr4 has pmin; - k5 has pmin; - k6 = 0.003; - k6 has pmin; - kr6 = 0.3; - kr6 has pmin; - k7 = 0.003; - k7 has pmin; - k8 = 0.0001; - k8 has pipmin; - kr8 = 12; - kr8 has pmin; - k10 = 3.25581; - k10 has pipmin; - kr10 = 0.66; - kr10 has pmin; - kr11 = 6; - kr11 has pmin; - k11 = 0.001; - k11 has pipmin; - kr12 = 0.6; - kr12 has pmin; - k12 = 60; - k12 has pmin; - k13 = 130.2; - k13 has ipmin; - k14 = 0.0001; - k14 has pipmin; - kr14 = 12; - kr14 has pmin; - k15 = 600000; - k15 has pmin; - kr16 = 16.5; - kr16 has pmin; - k16 = 0.001; - k16 has pipmin; - kr17 = 3.6; - kr17 has pmin; - k17 = 0.001; - k17 has pipmin; - kr18 = 78; - kr18 has pmin; - k18 = 0.0015; - k18 has pipmin; - kr19 = 1e-05; - kr19 has pipmin; - k19 = 30; - k19 has pmin; - kr20 = 24; - kr20 has pmin; - k20 = 0.00021; - k20 has pipmin; - k21 = 1.38; - k21 has pmin; - kr21 = 2.2e-05; - kr21 has pipmin; - k22 = 0.0021; - k22 has pipmin; - kr22 = 6; - kr22 has pmin; - k23 = 360; - k23 has pmin; - kr23 = 36; - kr23 has pmin; - k24 = 0.001; - k24 has pipmin; - kr24 = 33; - kr24 has pmin; - kr25 = 1.284; - kr25 has pmin; - k25 = 0.001; - k25 has pipmin; - k28 = 0.0001; - k28 has pipmin; - kr28 = 0.318; - kr28 has pmin; - k29 = 60; - k29 has pmin; - kr29 = 7e-05; - kr29 has pipmin; - kr32 = 2.4e-05; - kr32 has pipmin; - k32 = 6; - k32 has pmin; - k33 = 12; - k33 has pmin; - kr33 = 0.0021; - kr33 has pipmin; - k34 = 1.8; - k34 has pmin; - kr34 = 0.00045; - kr34 has pipmin; - k35 = 0.09; - k35 has pmin; - kr35 = 0.00045; - kr35 has pipmin; - Vm36 = 61200; - Vm36 has ipmin; - Km36 = 200000000000000; - Km36 has substance; - k37 = 18; - k37 has pmin; - kr37 = 9e-05; - kr37 has pipmin; - k40 = 0.003; - k40 has pipmin; - kr40 = 3.84; - kr40 has pmin; - kr41 = 2.574; - kr41 has pmin; - k41 = 0.003; - k41 has pipmin; - k42 = 0.0071; - k42 has pipmin; - kr42 = 12; - kr42 has pmin; - k43 = 60; - k43 has pmin; - kr44 = 1.0998; - kr44 has pmin; - k44 = 0.00111; - k44 has pipmin; - k45 = 210; - k45 has pmin; - k47 = 174; - k47 has pmin; - kr48 = 48; - kr48 has pmin; - k48 = 0.00143; - k48 has pipmin; - k49 = 3.48; - k49 has pmin; - kr50 = 30; - kr50 has pmin; - k50 = 2.5e-05; - k50 has pipmin; - k52 = 0.00534; - k52 has pipmin; - kr52 = 1.98; - kr52 has pmin; - k53 = 960; - k53 has pmin; - k55 = 342; - k55 has pmin; - kr56 = 36; - kr56 has pmin; - k56 = 0.00145; - k56 has pipmin; - k57 = 16.2; - k57 has pmin; - kr58 = 30; - kr58 has pmin; - k58 = 0.0005; - k58 has pipmin; - k59 = 18; - k59 has pmin; - k60 = 0.04002; - k60 has pmin; - k61 = 0.01002; - k61 has pmin; - RT = 50000; - RT has substance; - - // Other declarations: - var k5, C; - const c1, c2, c3, k1, kr1, kr2, k2, k3, kr3, k4, kr4, k6, kr6, k7, k8, kr8; - const k10, kr10, kr11, k11, kr12, k12, k13, k14, kr14, k15, kr16, k16, kr17; - const k17, kr18, k18, kr19, k19, kr20, k20, k21, kr21, k22, kr22, k23, kr23; - const k24, kr24, kr25, k25, k28, kr28, k29, kr29, kr32, k32, k33, kr33; - const k34, kr34, k35, kr35, Vm36, Km36, k37, kr37, k40, kr40, kr41, k41; - const k42, kr42, k43, kr44, k44, k45, k47, kr48, k48, k49, kr50, k50, k52; - const kr52, k53, k55, kr56, k56, k57, kr58, k58, k59, k60, k61, RT; - - // Unit definitions: - unit substance = item; - unit time_unit = 60 second; - unit volume = 1e-12 litre; - unit pmin = 1 / 60 second; - unit ipmin = item / 60 second; - unit pipmin = 1 / (60 second * item); - unit piplpmin = 1e-12 litre / (item * 60 second); - - // Display Names: - substance is "items"; - time_unit is "min"; - volume is "pl"; - pmin is "permin"; - ipmin is "itemspermin"; - pipmin is "peritempermin"; - piplpmin is "plperitempermin"; - c1 is "extracellular volume"; - c2 is "cytoplasm"; - c3 is "endosomal volume"; - x1 is "EGF"; - x2 is "EGFR"; - x3 is "EGF-EGFR"; - x4 is "EGF-EGFR^2"; - x5 is "EGF-EGFR*^2"; - x6 is "EGFRi"; - x7 is "EGF-EGFR*^2-GAP-Grb2-Prot"; - x8 is "EGF-EGFRi*^2"; - x9 is "Proti"; - x10 is "EGF-EGFRi"; - x11 is "EGF-EGFRi^2"; - x12 is "Prot"; - x13 is "EGFideg"; - x14 is "GAP"; - x15 is "EGF-EGFR*^2-GAP"; - x16 is "EGFi"; - x17 is "EGF-EGFRi*^2-GAP"; - x18 is "EGF-EGFRi*^2-GAP-Grb2"; - x19 is "EGF-EGFRi*^2-GAP-Grb2-Sos"; - x20 is "EGF-EGFRi*^2-GAP-Grb2-Sos-Ras-GDP"; - x21 is "EGF-EGFRi*^2-GAP-Grb2-Sos-Ras-GTP"; - x22 is "Grb2"; - x23 is "EGF-EGFR*^2-GAP-Grb2"; - x24 is "Sos"; - x25 is "EGF-EGFR*^2-GAP-Grb2-Sos"; - x26 is "Ras-GDP"; - x27 is "EGF-EGFR*^2-GAP-Grb2-Sos-Ras-GDP"; - x28 is "Ras-GTP"; - x29 is "EGF-EGFR*^2-GAP-Grb2-Sos-Ras-GTP"; - x30 is "Grb2-Sos"; - x31 is "Shc"; - x32 is "EGF-EGFR*^2-GAP-Shc"; - x33 is "EGF-EGFR*^2-GAP-Shc*"; - x34 is "EGF-EGFR*^2-GAP-Shc*-Grb2"; - x35 is "EGF-EGFR*^2-GAP-Shc*-Grb2-Sos"; - x36 is "EGF-EGFR*^2-GAP-Shc*-Grb2-Sos-Ras-GDP"; - x37 is "EGF-EGFR*^2-GAP-Shc*-Grb2-Sos-Ras-GTP"; - x38 is "Shc*-Grb2-Sos"; - x39 is "Shc*-Grb2"; - x40 is "Shc*"; - x41 is "Raf"; - x42 is "Raf-Ras-GTP"; - x43 is "Ras-GTP*"; - x44 is "Phosphotase1"; - x45 is "Raf*"; - x46 is "Raf*-P'ase"; - x47 is "MEK"; - x48 is "MEK-Raf*"; - x49 is "MEK-P"; - x50 is "MEK-P-Raf*"; - x51 is "MEK-PP"; - x52 is "MEK-PP-P'ase2"; - x53 is "Phosphatase2"; - x54 is "MEK-P-P'ase2"; - x55 is "ERK"; - x56 is "ERK-MEK-PP"; - x57 is "ERK-P"; - x58 is "ERK-P-MEK-PP"; - x59 is "ERK-PP"; - x60 is "Phosphotase3"; - x61 is "ERK-PP-P'ase3"; - x62 is "ERK-P-P'ase3"; - x63 is "EGF-EGFRi*^2-GAP-Shc"; - x64 is "EGF-EGFRi*^2-GAP-Shc*"; - x65 is "EGF-EGFRi*^2-GAP-Shc*-Grb2"; - x66 is "EGF-EGFRi*^2-GAP-Shc*-Grb2-Sos"; - x67 is "EGF-EGFRi*^2-GAP-Shc*-Grb2-Sos-Ras-GDP"; - x68 is "EGF-EGFRi*^2-GAP-Shc*-Grb2-Sos-Ras-GTP"; - x69 is "Rasi-GTP"; - x70 is "Rafi-Rasi-GTP"; - x71 is "Rasi-GTP*"; - x72 is "Rafi*"; - x73 is "Rafi*-P'ase"; - x74 is "MEKi-Rafi*"; - x75 is "MEKi-P"; - x76 is "MEKi-P-Rafi*"; - x77 is "MEKi-PP"; - x78 is "MEKi-PP-P'ase2i"; - x79 is "MEKi-P-P'ase2i"; - x80 is "ERKi-MEKi-PP"; - x81 is "ERKi-P"; - x82 is "ERKi-P-MEKi-PP"; - x83 is "ERKi-PP"; - x84 is "ERKi-PP-P'ase3i"; - x85 is "ERKi-P-P'ase3i"; - x86 is "EGFRideg"; - x87 is "EGF-EGFRi*^2deg"; - x88 is "EGF-EGFR*^2-GAP-Grb2-Sos-Prot"; - x89 is "EGF-EGFR*^2-GAP-Grb2-Sos-Ras-GDP-Prot"; - x90 is "EGF-EGFR*^2-GAP-Grb2-Sos-Ras-GTP-Prot"; - x91 is "EGF-EGFR*^2-GAP-Shc*-Grb2-Prot"; - x92 is "EGF-EGFR*^2-GAP-Shc*-Grb2-Sos-Prot"; - x93 is "EGF-EGFR*^2-GAP-Shc*-Grb2-Sos-Ras-GDP-Prot"; - x94 is "EGF-EGFR*^2-GAP-Shc*-Grb2-Sos-Ras-GTP-Prot"; - Raf_act is "t_Raf*"; - Ras_GTP is "t_Ras_GTP"; - MEK_PP is "t_MEK_PP"; - ERK_PP is "t_ERK_PP"; - SHC_P_t is "t_SHC_P_t"; - EGF_EGFR_act is "t_EGF_EGFR*"; - C is "C_internalization"; - RT is "total_Receptors"; - - // CV terms: - c1 identity "http://identifiers.org/go/GO:0005615" - c2 identity "http://identifiers.org/go/GO:0005737" - c3 identity "http://identifiers.org/go/GO:0005768" - x3 hypernym "http://identifiers.org/reactome/REACT_9893" - x3 version "http://identifiers.org/uniprot/P01133", - "http://identifiers.org/uniprot/P00533" - x4 hypernym "http://identifiers.org/reactome/REACT_9820" - x4 version "http://identifiers.org/uniprot/P01133", - "http://identifiers.org/uniprot/P00533" - x5 hypernym "http://identifiers.org/kegg.compound/C00562" - x5 version "http://identifiers.org/uniprot/P00533", - "http://identifiers.org/uniprot/P01133" - x6 hypernym "http://identifiers.org/uniprot/P00533" - x7 version "http://identifiers.org/uniprot/P20936", - "http://identifiers.org/uniprot/P62993", - "http://identifiers.org/uniprot/P00533", - "http://identifiers.org/uniprot/P01133", - "http://identifiers.org/go/GO:0030119" - x8 version "http://identifiers.org/uniprot/P00533", - "http://identifiers.org/uniprot/P01133" - x9 hypernym "http://identifiers.org/go/GO:0030119" - x10 version "http://identifiers.org/uniprot/P01133", - "http://identifiers.org/uniprot/P00533" - x14 hypernym "http://identifiers.org/interpro/IPR001936" - x14 hypernym "http://identifiers.org/uniprot/P20936" - x14 description "http://identifiers.org/omim/139150" - x22 hypernym "http://identifiers.org/uniprot/P62993" - x22 description "http://identifiers.org/omim/108355" - x24 hypernym "http://identifiers.org/uniprot/Q07889" - x24 description "http://identifiers.org/omim/182530" - x26 part "http://identifiers.org/chebi/CHEBI:17552", - "http://identifiers.org/uniprot/P01112" - x28 part "http://identifiers.org/chebi/CHEBI:15996", - "http://identifiers.org/uniprot/P01112" - x31 hypernym "http://identifiers.org/uniprot/P98077" - x31 description "http://identifiers.org/omim/605217" - x41 hypernym "http://identifiers.org/uniprot/P04049" - x41 description "http://identifiers.org/omim/164760" - x47 hypernym "http://identifiers.org/uniprot/Q02750", - "http://identifiers.org/uniprot/A4QPA9" - x47 description "http://identifiers.org/omim/176872" - x49 hypernym "http://identifiers.org/uniprot/Q02750", - "http://identifiers.org/uniprot/A4QPA9", - "http://identifiers.org/kegg.compound/C00562" - x49 description "http://identifiers.org/omim/176872" - x55 hypernym "http://identifiers.org/uniprot/P28482" - x55 description "http://identifiers.org/omim/176948" - v1 hypernym "http://identifiers.org/go/GO:0005154", - "http://identifiers.org/go/GO:0048408" - v1 hypernym "http://identifiers.org/reactome/REACT_9481" - v2 hypernym "http://identifiers.org/go/GO:0007171", - "http://identifiers.org/go/GO:0046983" - v2 hypernym "http://identifiers.org/reactome/REACT_9397" - v3 hypernym "http://identifiers.org/go/GO:0007171", - "http://identifiers.org/go/GO:0046777", - "http://identifiers.org/go/GO:0004713" - v3 hypernym "http://identifiers.org/reactome/REACT_9388" - v6 hypernym "http://identifiers.org/go/GO:0031623" - v7 hypernym "http://identifiers.org/go/GO:0031623" - v10 hypernym "http://identifiers.org/go/GO:0031623" - v100 description "http://identifiers.org/omim/164760" - v101 description "http://identifiers.org/omim/164760" -end - -BIOMD0000000019 is "Schoeberl2002 - EGF MAPK" - -BIOMD0000000019 model_entity_is "http://identifiers.org/biomodels.db/MODEL6617455076" -BIOMD0000000019 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000019" -BIOMD0000000019 description "http://identifiers.org/pubmed/11923843" -BIOMD0000000019 taxon "http://identifiers.org/taxonomy/9606" -BIOMD0000000019 hypernym "http://identifiers.org/reactome/REACT_9417.3", - "http://identifiers.org/go/GO:0007173" -BIOMD0000000019 version "http://identifiers.org/go/GO:0007265", - "http://identifiers.org/go/GO:0000165" diff --git a/BioModelsRAG/data/BIOMD0000000020.txt b/BioModelsRAG/data/BIOMD0000000020.txt deleted file mode 100644 index 37187972eb4970fc81a6d1e85ace4bc22a2abf0a..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000020.txt +++ /dev/null @@ -1,101 +0,0 @@ -// Created by libAntimony v2.13.0 -model *hhsa_1952() - - // Compartments and Species: - compartment unit_compartment; - - // Assignment Rules: - i_Na := g_Na*m^3*h*(V - V_Na); - i_K := g_K*n^4*(V - V_K); - i_L := g_L*(V - V_L); - V_neg := -V; - E := V + E_R; - V_Na := E_Na - E_R; - V_K := E_K - E_R; - V_L := E_L - E_R; - alpha_m := 0.1*(V + 25)/(exp((V + 25)/10) - 1); - beta_m := 4*exp(V/18); - alpha_h := 0.07*exp(V/20); - beta_h := 1/(exp((V + 30)/10) + 1); - alpha_n := 0.01*(V + 10)/(exp((V + 10)/10) - 1); - beta_n := 0.125*exp(V/80); - - // Rate Rules: - V' = (I - (i_Na + i_K + i_L))/Cm; - m' = alpha_m*(1 - m) - beta_m*m; - h' = alpha_h*(1 - h) - beta_h*h; - n' = alpha_n*(1 - n) - beta_n*n; - - // Compartment initializations: - unit_compartment = 1; - - // Variable initializations: - V = 0; - V has mV; - I = 0; - Cm = 1; - V_neg has mV; - E has mV; - E_R = -75; - E_R has mV; - g_Na = 120; - m = 0.052932; - h = 0.59612; - V_Na has mV; - g_K = 36; - n = 0.31768; - V_K has mV; - g_L = 0.3; - V_L has mV; - E_Na = -190; - E_Na has mV; - E_K = -63; - E_K has mV; - E_L = -85.613; - E_L has mV; - - // Other declarations: - var V, i_Na, i_K, i_L, V_neg, E, m, h, V_Na, n, V_K, V_L, alpha_m, beta_m; - var alpha_h, beta_h, alpha_n, beta_n; - const unit_compartment, I, Cm, E_R, g_Na, g_K, g_L, E_Na, E_K, E_L; - - // Unit definitions: - unit time_unit = 1e-3 second; - unit mV = 1e-3 volt; - - // Display Names: - time_unit is "millisecond"; - alpha_h is "auxiliary alpha_h"; - - // SBO terms: - V.sboTerm = 259 - Cm.sboTerm = 258 - V_neg.sboTerm = 259 - E.sboTerm = 259 - E_R.sboTerm = 259 - g_Na.sboTerm = 257 - V_Na.sboTerm = 259 - g_K.sboTerm = 257 - V_K.sboTerm = 259 - g_L.sboTerm = 257 - V_L.sboTerm = 259 - E_Na.sboTerm = 259 - E_K.sboTerm = 259 - E_L.sboTerm = 259 - - // CV terms: - i_Na hypernym "http://identifiers.org/obo.go/GO:0005248" - i_K hypernym "http://identifiers.org/obo.go/GO:0008076" - i_L hypernym "http://identifiers.org/obo.go/GO:0022840" -end - -hhsa_1952 is "hodgkin-huxley squid-axon 1952" - -hhsa_1952 model_entity_is "http://identifiers.org/biomodels.db/MODEL6617668482" -hhsa_1952 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000020" -hhsa_1952 description "http://identifiers.org/pubmed/12991237" -hhsa_1952 hypernym "http://identifiers.org/obo.go/GO:0019227", - "http://identifiers.org/obo.go/GO:0005248", - "http://identifiers.org/obo.go/GO:0005249" -hhsa_1952 taxon "http://identifiers.org/taxonomy/6618", - "http://identifiers.org/obo.go/GO:0042757" diff --git a/BioModelsRAG/data/BIOMD0000000021.txt b/BioModelsRAG/data/BIOMD0000000021.txt deleted file mode 100644 index 0c51ff8c820da6e8e25ee7d2e5bee68b7367f264..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000021.txt +++ /dev/null @@ -1,214 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Leloup1999_CircClock_periodic() - - // Compartments and Species: - compartment Cell, compartment_0000002; - species P0 in Cell, T0 in Cell, P1 in Cell, T1 in Cell, P2 in Cell, T2 in Cell; - species CC in Cell, Cn in compartment_0000002, Mp in Cell, Mt in Cell; - - // Assignment Rules: - Pt := CC + Cn + P0 + P1 + P2; - Tt := CC + Cn + T0 + T1 + T2; - - // Reactions: - P0_to_P1: P0 => P1; Cell*P0_to_P1_V_1P*P0/(P0_to_P1_K1_P + P0); - T0_to_T1: T0 => T1; Cell*T0_to_T1_V_1T*T0/(T0_to_T1_K_1T + T0); - P1_to_P0: P1 => P0; Cell*P1_to_P0_V_2P*P1/(P1_to_P0_K_2P + P1); - T1_to_T0: T1 => T0; Cell*T1_to_T0_V_2T*T1/(T1_to_T0_K_2T + T1); - P1_to_P2: P1 => P2; Cell*P1_to_P2_V_3P*P1/(P1_to_P2_K_3P + P1); - T1_to_T2: T1 => T2; Cell*T1_to_T2_V_3T*T1/(T1_to_T2_K_3T + T1); - P2_to_P1: P2 => P1; Cell*P2_to_P1_V_4P*P2/(P2_to_P1_K_4P + P2); - T2_to_T1: T2 => T1; Cell*T2_to_T1_V_4T*T2/(T2_to_T1_K_4T + T2); - P0_degradation: P0 => ; Cell*P0_degradation_k_d*P0; - T0_degradation: T0 => ; Cell*T0_degradation_k_d*T0; - P1_degradation: P1 => ; Cell*P1_degradation_k_d*P1; - T1_degradation: T1 => ; Cell*T1_degradation_k_d*T1; - P2_degradation: P2 => ; Cell*P2_degradation_k_d*P2 + Cell*P2_degradation_V_dP*P2/(P2_degradation_K_dP + P2); - T2_degradation: T2 => ; Cell*T2_degradation_k_d*T2 + Cell*V_dT*T2/(T2_degradation_K_dT + T2); - PT_complex_formation: P2 + T2 -> CC; Cell*PT_complex_formation_k3*P2*T2 - Cell*PT_complex_formation_k4*CC; - PT_complex_nucleation: CC -> Cn; Cell*PT_complex_nucleation_k1*CC - compartment_0000002*PT_complex_nucleation_k2*Cn; - PT_complex_degradation: CC => ; Cell*PT_complex_degradation_k_dC*CC; - PTnucl_complex_degradation: Cn => ; compartment_0000002*PTnucl_complex_degradation_k_dN*Cn; - Mp_production: => Mp; Cell*Mp_production_v_sP*Mp_production_K_IP^Mp_production_n/(Mp_production_K_IP^Mp_production_n + Cn^Mp_production_n); - Mt_production: => Mt; Cell*Mt_production_V_sT*Mt_production_K_IT^Mt_production_n/(Mt_production_K_IT^Mt_production_n + Cn^Mt_production_n); - P0_production: => P0; Cell*P0_production_k_sP*Mp; - T0_production: => T0; Cell*T0_production_k_sT*Mt; - Mp_degradation: Mp => ; Cell*Mp_degradation_k_d*Mp + Cell*Mp_degradation_V_mP*Mp/(Mp_degradation_K_mP + Mp); - Mt_degradation: Mt => ; Cell*Mt_degradation_k_d*Mt + Cell*V_mT*Mt/(Mt_degradation_K_mT + Mt); - - // Species initializations: - P0 = 0; - T0 = 0; - P1 = 0; - T1 = 0; - P2 = 0; - T2 = 0; - CC = 0; - Cn = 0; - Mp = 0; - Mt = 0; - - // Compartment initializations: - Cell = 1; - compartment_0000002 = 1; - - // Variable initializations: - V_mT = 0.7; - V_dT = 2; - P0_to_P1_K1_P = 2; - P0_to_P1_V_1P = 8; - T0_to_T1_K_1T = 2; - T0_to_T1_V_1T = 8; - P1_to_P0_K_2P = 2; - P1_to_P0_V_2P = 1; - T1_to_T0_K_2T = 2; - T1_to_T0_V_2T = 1; - P1_to_P2_K_3P = 2; - P1_to_P2_V_3P = 8; - T1_to_T2_K_3T = 2; - T1_to_T2_V_3T = 8; - P2_to_P1_K_4P = 2; - P2_to_P1_V_4P = 1; - T2_to_T1_K_4T = 2; - T2_to_T1_V_4T = 1; - P0_degradation_k_d = 0.01; - T0_degradation_k_d = 0.01; - P1_degradation_k_d = 0.01; - T1_degradation_k_d = 0.01; - P2_degradation_k_d = 0.01; - P2_degradation_V_dP = 2; - P2_degradation_K_dP = 0.2; - T2_degradation_k_d = 0.01; - T2_degradation_K_dT = 0.2; - PT_complex_formation_k3 = 1.2; - PT_complex_formation_k4 = 0.6; - PT_complex_nucleation_k1 = 0.6; - PT_complex_nucleation_k2 = 0.2; - PT_complex_degradation_k_dC = 0.01; - PTnucl_complex_degradation_k_dN = 0.01; - Mp_production_v_sP = 1; - Mp_production_K_IP = 1; - Mp_production_n = 4; - Mt_production_V_sT = 1; - Mt_production_K_IT = 1; - Mt_production_n = 4; - P0_production_k_sP = 0.9; - T0_production_k_sT = 0.9; - Mp_degradation_k_d = 0.01; - Mp_degradation_V_mP = 0.7; - Mp_degradation_K_mP = 0.2; - Mt_degradation_k_d = 0.01; - Mt_degradation_K_mT = 0.2; - - // Other declarations: - var Pt, Tt; - const Cell, compartment_0000002, V_mT, V_dT; - - // Unit definitions: - unit substance = 1e-9 mole; - unit time_unit = 3600 second; - - // Display Names: - substance is "nanomole (default)"; - time_unit is "hour (default)"; - Cell is "cytoplasm"; - compartment_0000002 is "nucleus"; - P0 is "PER Protein (unphosphorylated)"; - T0 is "TIM Protein (unphosphorylated)"; - P1 is "PER Protein (mono-phosphorylated)"; - T1 is "TIM Protein (mono-phosphorylated)"; - P2 is "PER Protein (bi-phosphorylated)"; - T2 is "TIM Protein (bi-phosphorylated)"; - CC is "Cytosolic PER-TIM Complex"; - Cn is "Nuclear PER-TIM Complex"; - Mp is "PER mRNA"; - Mt is "TIM mRNA"; - Pt is "Total Per"; - Tt is "Total Tim"; - P0_to_P1 is "First Phosphorylation of PER"; - T0_to_T1 is "First Phosphorylation of TIM"; - P1_to_P0 is "Dephosphorylation of PER (1st P)"; - T1_to_T0 is "Dephosphorylation of TIM (1st P)"; - P1_to_P2 is "Second Phosphorylation of PER"; - T1_to_T2 is "Second Phosphorylation of TIM"; - P2_to_P1 is "Dephosphorylation of PER (2nd P)"; - T2_to_T1 is "Dephosphorylation of TIM (2nd P)"; - P0_degradation is "PER degradation"; - T0_degradation is "TIM degradation"; - P1_degradation is "PER-1 degradation"; - T1_degradation is "TIM-1 degradation"; - P2_degradation is "PER-2 degradation"; - T2_degradation is "TIM-2 degradation"; - PT_complex_formation is "PER-TIM complex formation"; - PT_complex_nucleation is "PER-TIM complex nucleation"; - PT_complex_degradation is "PER-TIM complex degradation (cytosol)"; - PTnucl_complex_degradation is "PER-TIM complex degradation (nuclear)"; - Mp_production is "PER mRNA production"; - Mt_production is "TIM mRNA production"; - P0_production is "PER production"; - T0_production is "TIM production"; - Mp_degradation is "PER mRNA degradation"; - Mt_degradation is "TIM mRNA degradation"; - - // CV terms: - Cell identity "http://identifiers.org/go/GO:0005737" - compartment_0000002 identity "http://identifiers.org/go/GO:0005634" - P0 hypernym "http://identifiers.org/uniprot/P07663" - T0 hypernym "http://identifiers.org/uniprot/P49021" - P1 hypernym "http://identifiers.org/uniprot/P07663" - T1 hypernym "http://identifiers.org/uniprot/P49021" - P2 hypernym "http://identifiers.org/uniprot/P07663" - T2 hypernym "http://identifiers.org/uniprot/P49021" - CC part "http://identifiers.org/uniprot/P49021", - "http://identifiers.org/uniprot/P07663" - Cn part "http://identifiers.org/uniprot/P49021", - "http://identifiers.org/uniprot/P07663" - Mp hypernym "http://identifiers.org/chebi/CHEBI:33699", - "http://identifiers.org/kegg.compound/C00046" - Mt hypernym "http://identifiers.org/chebi/CHEBI:33699", - "http://identifiers.org/kegg.compound/C00046" - P0_to_P1 hypernym "http://identifiers.org/ec-code/2.7.11.1", - "http://identifiers.org/go/GO:0006468" - T0_to_T1 hypernym "http://identifiers.org/ec-code/2.7.11.1", - "http://identifiers.org/go/GO:0006468" - P1_to_P0 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0006470" - T1_to_T0 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0006470" - P1_to_P2 hypernym "http://identifiers.org/ec-code/2.7.11.1", - "http://identifiers.org/go/GO:0006468" - T1_to_T2 hypernym "http://identifiers.org/ec-code/2.7.11.1", - "http://identifiers.org/go/GO:0006468" - P2_to_P1 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0006470" - T2_to_T1 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0006470" - P0_degradation hypernym "http://identifiers.org/go/GO:0030163" - T0_degradation hypernym "http://identifiers.org/go/GO:0030163" - P1_degradation hypernym "http://identifiers.org/go/GO:0030163" - T1_degradation hypernym "http://identifiers.org/go/GO:0030163" - P2_degradation hypernym "http://identifiers.org/go/GO:0030163" - T2_degradation hypernym "http://identifiers.org/go/GO:0030163" - PT_complex_formation hypernym "http://identifiers.org/go/GO:0006461" - PT_complex_nucleation hypernym "http://identifiers.org/go/GO:0006606" - PT_complex_degradation hypernym "http://identifiers.org/go/GO:0030163" - PTnucl_complex_degradation hypernym "http://identifiers.org/go/GO:0030163" - Mp_production hypernym "http://identifiers.org/go/GO:0009299", - "http://identifiers.org/go/GO:0006355" - Mt_production hypernym "http://identifiers.org/go/GO:0009299", - "http://identifiers.org/go/GO:0006355" - P0_production hypernym "http://identifiers.org/go/GO:0006412" - T0_production hypernym "http://identifiers.org/go/GO:0006412" - Mp_degradation hypernym "http://identifiers.org/go/GO:0006402" - Mt_degradation hypernym "http://identifiers.org/go/GO:0006402" -end - -Leloup1999_CircClock_periodic is "Leloup1999_CircClock" - -Leloup1999_CircClock_periodic model_entity_is "http://identifiers.org/biomodels.db/MODEL6617834203" -Leloup1999_CircClock_periodic model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000021" -Leloup1999_CircClock_periodic description "http://identifiers.org/pubmed/10366496" -Leloup1999_CircClock_periodic origin "http://identifiers.org/biomodels.db/BIOMD0000000171" -Leloup1999_CircClock_periodic taxon "http://identifiers.org/taxonomy/7227" -Leloup1999_CircClock_periodic identity "http://identifiers.org/kegg.pathway/dme04710" -Leloup1999_CircClock_periodic hypernym "http://identifiers.org/go/GO:0042752" diff --git a/BioModelsRAG/data/BIOMD0000000022.txt b/BioModelsRAG/data/BIOMD0000000022.txt deleted file mode 100644 index 1668b0861844e56953eb512308ec2b3a655391c1..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000022.txt +++ /dev/null @@ -1,257 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Ueda2001_CircClock() - - // Compartments and Species: - compartment Drosophilia, compartment_0000003, compartment_0000002; - species $EmptySet in Drosophilia, CCc in compartment_0000003, CCn in compartment_0000002; - species Clkc in compartment_0000003, Clkm in compartment_0000003, Perc in compartment_0000003; - species Perm in compartment_0000003, PTc in compartment_0000003, PTn in compartment_0000002; - species Timc in compartment_0000003, Timm in compartment_0000003, $species_0000012 in compartment_0000003; - species $species_0000013 in compartment_0000003; - - // Reactions: - Reaction1: $EmptySet => Perm; compartment_0000003*(Reaction1_c1 + (Reaction1_B1 + (CCn/Reaction1_A1)^Reaction1_a)*Reaction1_s1/(1 + Reaction1_B1 + (CCn/Reaction1_A1)^Reaction1_a + (PTn/Reaction1_r1)^Reaction1_r)); - Reaction2: Perm => $EmptySet; compartment_0000003*Reaction2_D0*Perm; - Reaction3: $EmptySet => Timm; compartment_0000003*(Reaction3_c2 + (Reaction3_B2 + (CCn/Reaction3_A2)^Reaction3_a)*Reaction3_s3/(1 + Reaction3_B2 + (CCn/Reaction3_A2)^Reaction3_a + (PTn/Reaction3_r2)^Reaction3_r)); - Reaction4: Timm => $EmptySet; Drosophilia*Reaction4_D0*Timm; - Reaction5: $EmptySet => Clkm; compartment_0000003*(Reaction5_c3 + (Reaction5_B3 + (PTn/Reaction5_A3)^Reaction5_a)*Reaction5_s5/(1 + Reaction5_B3 + (PTn/Reaction5_A3)^Reaction5_a + (CCn/Reaction5_r3)^Reaction5_r)); - Reaction6: Clkm => $EmptySet; Drosophilia*Clkm*Reaction6_D0; - Reaction7: CCc => CCn; compartment_0000003*(CCc*Reaction7_T3/(Reaction7_k3 + CCc)); - Reaction8: CCn => CCc; compartment_0000002*(CCn*Reaction8_T4/(Reaction8_k4 + CCn)); - Reaction9: PTn => PTc; compartment_0000002*(PTn*Reaction9_T2/(Reaction9_k2 + PTn)); - Reaction10: PTc => PTn; compartment_0000003*(PTc*Reaction10_T1/(Reaction10_k1 + PTc)); - Reaction11: $species_0000012 + Clkc -> CCc; compartment_0000003*(Clkc*Reaction11_v3*species_0000012 - Reaction11_parameter_0000073*CCc); - Reaction12: Perc + Timc -> PTc; compartment_0000003*(Perc*Timc*Reaction12_v1 - Reaction12_parameter_0000072*PTc); - Reaction16: $EmptySet => Timc; compartment_0000003*Reaction16_s4*Timm; - Reaction18: $EmptySet => Clkc; compartment_0000003*Clkm*Reaction18_s6; - Reaction19: $EmptySet => Perc; compartment_0000003*Reaction19_s2*Perm; - Reaction20: Perc => $EmptySet; Drosophilia*Reaction20_D0*Perc; - Reaction21: PTc => $EmptySet; compartment_0000003*Reaction21_D0*PTc; - Reaction23: PTn => $EmptySet; compartment_0000002*Reaction23_D0*PTn; - Reaction24: CCc => $EmptySet; compartment_0000003*CCc*Reaction24_D0; - Reaction25: Clkc => $EmptySet; compartment_0000003*Clkc*Reaction25_D0; - Reaction26: CCn => $EmptySet; compartment_0000002*CCn*Reaction26_D0; - Reaction27: Timc => $EmptySet; compartment_0000003*Reaction27_D0*Timc; - Reaction28: Perm => $EmptySet; compartment_0000003*(Reaction28_D1*Perm/(Reaction28_L1 + Perm)); - Reaction29: Perc => $EmptySet; compartment_0000003*(Reaction29_D2*species_0000013*Perc/(Reaction29_L2 + Perc)); - Reaction30: Timm => $EmptySet; compartment_0000003*(Reaction30_D3*Timm/(Reaction30_L3 + Timm)); - Reaction31: Timc => $EmptySet; compartment_0000003*(Reaction31_D4*Timc/(Reaction31_L4 + Timc)); - Reaction32: PTc => $EmptySet; compartment_0000003*(Reaction32_D5*PTc/(Reaction32_L5 + PTc)); - Reaction33: PTn => $EmptySet; compartment_0000002*(Reaction33_D6*PTn/(Reaction33_L6 + PTn)); - Reaction34: Clkm => $EmptySet; compartment_0000003*(Clkm*Reaction34_D7/(Clkm + Reaction34_L7)); - Reaction35: Clkc => $EmptySet; compartment_0000003*(Clkc*Reaction35_D8/(Clkc + Reaction35_L8)); - Reaction36: CCc => $EmptySet; compartment_0000003*(CCc*Reaction36_D9/(CCc + Reaction36_L9)); - Reaction37: CCn => $EmptySet; compartment_0000002*(CCn*Reaction37_D10/(CCn + Reaction37_L10)); - - // Species initializations: - EmptySet = 0; - CCc = 0.3/compartment_0000003; - CCn = 0.4/compartment_0000002; - Clkc = 0.2/compartment_0000003; - Clkm = 0.1/compartment_0000003; - Perc = 0.6/compartment_0000003; - Perm = 0.5/compartment_0000003; - PTc = 0.9/compartment_0000003; - PTn = 1/compartment_0000002; - Timc = 0.8/compartment_0000003; - Timm = 0.7/compartment_0000003; - species_0000012 = 1/compartment_0000003; - species_0000013 = 1/compartment_0000003; - - // Compartment initializations: - Drosophilia = 1; - compartment_0000003 = 1; - compartment_0000002 = 1; - - // Variable initializations: - Reaction1_a = 1; - Reaction1_A1 = 0.45; - Reaction1_B1 = 0; - Reaction1_c1 = 0; - Reaction1_r1 = 1.02; - Reaction1_s1 = 1.45; - Reaction1_r = 4; - Reaction2_D0 = 0.012; - Reaction3_a = 1; - Reaction3_A2 = 0.45; - Reaction3_B2 = 0; - Reaction3_c2 = 0; - Reaction3_r2 = 1.02; - Reaction3_s3 = 1.45; - Reaction3_r = 4; - Reaction4_D0 = 0.012; - Reaction5_a = 1; - Reaction5_A3 = 0.8; - Reaction5_B3 = 0.6; - Reaction5_c3 = 0; - Reaction5_r3 = 0.89; - Reaction5_s5 = 1.63; - Reaction5_r = 4; - Reaction6_D0 = 0.012; - Reaction7_k3 = 2; - Reaction7_T3 = 1.63; - Reaction8_k4 = 2; - Reaction8_T4 = 0.52; - Reaction9_k2 = 2; - Reaction9_T2 = 0.72; - Reaction10_k1 = 2; - Reaction10_T1 = 1.73; - Reaction11_v3 = 1.63; - Reaction11_parameter_0000073 = 1.63; - Reaction12_v1 = 1.45; - Reaction12_parameter_0000072 = 1.45; - Reaction16_s4 = 0.48; - Reaction18_s6 = 0.47; - Reaction19_s2 = 0.48; - Reaction20_D0 = 0.012; - Reaction21_D0 = 0.012; - Reaction23_D0 = 0.012; - Reaction24_D0 = 0.012; - Reaction25_D0 = 0.012; - Reaction26_D0 = 0.012; - Reaction27_D0 = 0.012; - Reaction28_D1 = 0.94; - Reaction28_L1 = 0.3; - Reaction29_D2 = 0.44; - Reaction29_L2 = 0.2; - Reaction30_D3 = 0.94; - Reaction30_L3 = 0.3; - Reaction31_D4 = 0.44; - Reaction31_L4 = 0.2; - Reaction32_D5 = 0.44; - Reaction32_L5 = 0.2; - Reaction33_D6 = 0.29; - Reaction33_L6 = 0.2; - Reaction34_D7 = 0.54; - Reaction34_L7 = 0.13; - Reaction35_D8 = 0.6; - Reaction35_L8 = 0.2; - Reaction36_D9 = 0.6; - Reaction36_L9 = 0.2; - Reaction37_D10 = 0.3; - Reaction37_L10 = 0.2; - - // Other declarations: - const Drosophilia, compartment_0000003, compartment_0000002; - - // Unit definitions: - unit substance = 1e-9 mole; - unit time_unit = 3600 second; - - // Display Names: - substance is "nanomole (default)"; - time_unit is "hour (default)"; - compartment_0000003 is "cytoplasm"; - compartment_0000002 is "nucleus"; - CCc is "Clk-Cyc_cyt"; - CCn is "Clk-Cyc_nuc"; - Clkc is "Clk_cyt"; - Clkm is "Clk_mRNA"; - Perc is "Per_cyt"; - Perm is "Per_mRNA"; - PTc is "Per-Tim_cyt"; - PTn is "Per-Tim_nuc"; - Timc is "Tim_cyt"; - Timm is "Tim_mRNA"; - species_0000012 is "Cyc_cyt"; - species_0000013 is "Dbt_cyt"; - Reaction1 is "Per transcription"; - Reaction2 is "non-specific Per mRNA degradation"; - Reaction3 is "Tim transcription"; - Reaction4 is "non-specific Tim mRNA degradation"; - Reaction5 is "Clk transcription"; - Reaction6 is "non-specific Clk mRNA degradation"; - Reaction7 is "Clk-Cyc nuclear import"; - Reaction8 is "Clk-Cyc nuclear export"; - Reaction9 is "Per-Tim nuclear export"; - Reaction10 is "Per-Tim nuclear import"; - Reaction11 is "Clk Cyc equilibrium"; - Reaction12 is "Per Tim equilibrium"; - Reaction16 is "Tim translation"; - Reaction18 is "Clk translation"; - Reaction19 is "Per translation"; - Reaction20 is "non-specific Per_cyt degradation"; - Reaction21 is "non-specific Per-Tim_cyt degradation"; - Reaction23 is "non-specific Per-Tim_nuc degradation"; - Reaction24 is "non-specific Clk-Cyc_cyt degradation"; - Reaction25 is "non-specific Clk_cyt degradation"; - Reaction26 is "non-specific Clk-Cyc_nuc degradation"; - Reaction27 is "non-specific Tim_cyt degradation"; - Reaction28 is "Per mRNA degradation"; - Reaction29 is "Dbt regulated Per_cyt degradation"; - Reaction30 is "Tim mRNA degradation"; - Reaction31 is "Tim_cyt degradation"; - Reaction32 is "Per-Tim_cyt degradation"; - Reaction33 is "Per-Tim_nuc degradation"; - Reaction34 is "Clk mRNA degradation"; - Reaction35 is "Clk_cyt degradation"; - Reaction36 is "Clk-Cyc_cyt degradation"; - - // CV terms: - compartment_0000003 identity "http://identifiers.org/go/GO:0005737" - compartment_0000002 identity "http://identifiers.org/go/GO:0005634" - CCc part "http://identifiers.org/uniprot/O61735", - "http://identifiers.org/uniprot/O61734" - CCn part "http://identifiers.org/uniprot/O61734", - "http://identifiers.org/uniprot/O61735" - Clkc identity "http://identifiers.org/uniprot/O61735" - Clkm hypernym "http://identifiers.org/chebi/CHEBI:33699", - "http://identifiers.org/kegg.compound/C00046" - Perc identity "http://identifiers.org/uniprot/P07663" - Perm hypernym "http://identifiers.org/chebi/CHEBI:33699", - "http://identifiers.org/kegg.compound/C00046" - PTc part "http://identifiers.org/uniprot/P07663", - "http://identifiers.org/uniprot/P49021" - PTn part "http://identifiers.org/uniprot/P07663", - "http://identifiers.org/uniprot/P49021" - Timc identity "http://identifiers.org/uniprot/P49021" - Timm hypernym "http://identifiers.org/chebi/CHEBI:33699", - "http://identifiers.org/kegg.compound/C00046" - species_0000012 identity "http://identifiers.org/uniprot/O61734" - species_0000013 identity "http://identifiers.org/uniprot/O76324" - Reaction1 hypernym "http://identifiers.org/go/GO:0006355", - "http://identifiers.org/go/GO:0009299" - Reaction2 hypernym "http://identifiers.org/go/GO:0006402" - Reaction3 hypernym "http://identifiers.org/go/GO:0009299", - "http://identifiers.org/go/GO:0006355" - Reaction4 hypernym "http://identifiers.org/go/GO:0006402" - Reaction5 hypernym "http://identifiers.org/go/GO:0009299", - "http://identifiers.org/go/GO:0006355" - Reaction6 hypernym "http://identifiers.org/go/GO:0006402" - Reaction7 hypernym "http://identifiers.org/go/GO:0006606" - Reaction8 hypernym "http://identifiers.org/go/GO:0006611" - Reaction9 hypernym "http://identifiers.org/go/GO:0006611" - Reaction10 hypernym "http://identifiers.org/go/GO:0006606" - Reaction11 hypernym "http://identifiers.org/go/GO:0006461" - Reaction12 hypernym "http://identifiers.org/go/GO:0006461" - Reaction16 hypernym "http://identifiers.org/go/GO:0006412" - Reaction18 hypernym "http://identifiers.org/go/GO:0006412" - Reaction19 hypernym "http://identifiers.org/go/GO:0006412" - Reaction20 hypernym "http://identifiers.org/go/GO:0030163" - Reaction21 hypernym "http://identifiers.org/go/GO:0030163" - Reaction23 hypernym "http://identifiers.org/go/GO:0030163" - Reaction24 hypernym "http://identifiers.org/go/GO:0030163" - Reaction25 hypernym "http://identifiers.org/go/GO:0030163" - Reaction26 hypernym "http://identifiers.org/go/GO:0030163" - Reaction27 hypernym "http://identifiers.org/go/GO:0030163" - Reaction28 hypernym "http://identifiers.org/go/GO:0006402" - Reaction29 hypernym "http://identifiers.org/go/GO:0030163" - Reaction30 hypernym "http://identifiers.org/go/GO:0006402" - Reaction31 hypernym "http://identifiers.org/go/GO:0030163" - Reaction32 hypernym "http://identifiers.org/go/GO:0030163" - Reaction33 hypernym "http://identifiers.org/go/GO:0030163" - Reaction34 hypernym "http://identifiers.org/go/GO:0006402" - Reaction35 hypernym "http://identifiers.org/go/GO:0030163" - Reaction36 hypernym "http://identifiers.org/go/GO:0030163" - Reaction37 hypernym "http://identifiers.org/go/GO:0030163" -end - -Ueda2001_CircClock is "Ueda2001_CircClock" - -Ueda2001_CircClock model_entity_is "http://identifiers.org/biomodels.db/MODEL6617909980" -Ueda2001_CircClock model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000022" -Ueda2001_CircClock description "http://identifiers.org/pubmed/11403560" -Ueda2001_CircClock origin "http://identifiers.org/pubmed/10531060" -Ueda2001_CircClock hypernym "http://identifiers.org/kegg.pathway/dme04710" -Ueda2001_CircClock taxon "http://identifiers.org/taxonomy/7227" -Ueda2001_CircClock hypernym "http://identifiers.org/go/GO:0042752" diff --git a/BioModelsRAG/data/BIOMD0000000023.txt b/BioModelsRAG/data/BIOMD0000000023.txt deleted file mode 100644 index 6e6226959a5bbe96576779a23f7c303427301bc2..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000023.txt +++ /dev/null @@ -1,175 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Rohwer2001_Sucrose() - - // Compartments and Species: - compartment compartment_; - species Fru in compartment_, Glc in compartment_, HexP in compartment_; - species Suc6P in compartment_, Suc in compartment_, $Sucvac in compartment_; - species $glycolysis in compartment_, $phos in compartment_, $UDP in compartment_; - species $ADP in compartment_, $ATP in compartment_, $Glcex in compartment_; - species $Fruex in compartment_; - - // Reactions: - v1: $Fruex -> Fru; compartment_*(v1_Vmax1*Fruex/(v1_Km1Fruex*(1 + Fru/v1_Ki1Fru) + Fruex)); - v2: $Glcex -> Glc; compartment_*(v2_Vmax2*Glcex/(v2_Km2Glcex*(1 + Glc/v2_Ki2Glc) + Glcex)); - v3: $ATP + Glc -> HexP + $ADP; compartment_*(v3_Vmax3*(Glc/v3_Km3Glc)*(ATP/v3_Km3ATP)/((1 + ATP/v3_Km3ATP)*(1 + Glc/v3_Km3Glc + Fru/v3_Km4Fru + 0.113*HexP/v3_Ki3G6P + 0.0575*HexP/v3_Ki4F6P))); - v4: Fru + $ATP -> HexP + $ADP; compartment_*(v4_Vmax4*(Fru/v4_Km4Fru)*(ATP/v4_Km4ATP)/((1 + ATP/v4_Km4ATP)*(1 + Glc/v4_Km3Glc + Fru/v4_Km4Fru + 0.113*HexP/v4_Ki3G6P + 0.0575*HexP/v4_Ki4F6P))); - v5: Fru + $ATP -> HexP + $ADP; compartment_*((v5_Vmax5/(1 + Fru/v5_Ki5Fru))*(Fru/v5_Km5Fru)*(ATP/v5_Km5ATP)/(1 + Fru/v5_Km5Fru + ATP/v5_Km5ATP + Fru*ATP/(v5_Km5Fru*v5_Km5ATP) + ADP/v5_Ki5ADP)); - v6: 2 HexP -> $UDP + Suc6P; compartment_*(v6_Vmax6f*(0.0575*HexP*0.8231*HexP - Suc6P*UDP/v6_Keq6)/(0.0575*HexP*0.8231*HexP*(1 + Suc6P/v6_Ki6Suc6P) + v6_Km6F6P*(1 + phos/v6_Ki6Pi)*(0.8231*HexP + v6_Ki6UDPGlc) + v6_Km6UDPGlc*0.0575*HexP + (v6_Vmax6f/(v6_Vmax6r*v6_Keq6))*(v6_Km6UDP*Suc6P*(1 + 0.8231*HexP/v6_Ki6UDPGlc) + UDP*(v6_Km6Suc6P*(1 + v6_Km6UDPGlc*0.0575*HexP/(v6_Ki6UDPGlc*v6_Km6F6P*(1 + phos/v6_Ki6Pi))) + Suc6P*(1 + 0.0575*HexP/v6_Ki6F6P))))); - v7: Suc6P -> Suc + $phos; compartment_*(v7_Vmax7*Suc6P/(v7_Km7Suc6P + Suc6P)); - v8: HexP + Fru -> Suc + $UDP; compartment_*(-v8_Vmax8f*(Suc*UDP - Fru*0.8231*HexP/v8_Keq8)/(Suc*UDP*(1 + Fru/v8_Ki8Fru) + v8_Km8Suc*(UDP + v8_Ki8UDP) + v8_Km8UDP*Suc + (v8_Vmax8f/(v8_Vmax8r*v8_Keq8))*(v8_Km8UDPGlc*Fru*(1 + UDP/v8_Ki8UDP) + 0.8231*HexP*(v8_Km8Fru*(1 + v8_Km8UDP*Suc/(v8_Ki8UDP*v8_Km8Suc)) + Fru*(1 + Suc/v8_Ki8Suc))))); - v9: Suc -> Fru + Glc; compartment_*((v9_Vmax9/(1 + Glc/v9_Ki9Glc))*Suc/(v9_Km9Suc*(1 + Fru/v9_Ki9Fru) + Suc)); - v10: HexP -> $glycolysis; compartment_*(v10_Vmax10*0.0575*HexP/(v10_Km10F6P + 0.0575*HexP)); - v11: Suc -> $Sucvac; compartment_*(v11_Vmax11*Suc/(v11_Km11Suc + Suc)); - - // Species initializations: - Fru = 1; - Glc = 1; - HexP = 1; - Suc6P = 1; - Suc = 1; - Sucvac = 0; - glycolysis = 0; - phos = 5.1; - UDP = 0.2; - ADP = 0.2; - ATP = 1; - Glcex = 5; - Fruex = 5; - - // Compartment initializations: - compartment_ = 1; - - // Variable initializations: - v1_Vmax1 = 0.286; - v1_Km1Fruex = 0.2; - v1_Ki1Fru = 1; - v2_Vmax2 = 0.286; - v2_Km2Glcex = 0.2; - v2_Ki2Glc = 1; - v3_Vmax3 = 0.197; - v3_Km3Glc = 0.07; - v3_Km3ATP = 0.25; - v3_Km4Fru = 10; - v3_Ki3G6P = 0.1; - v3_Ki4F6P = 10; - v4_Vmax4 = 0.197; - v4_Km4Fru = 10; - v4_Km4ATP = 0.25; - v4_Km3Glc = 0.07; - v4_Ki3G6P = 0.1; - v4_Ki4F6P = 10; - v5_Vmax5 = 0.164; - v5_Ki5Fru = 12; - v5_Km5Fru = 0.1; - v5_Km5ATP = 0.085; - v5_Ki5ADP = 2; - v6_Vmax6f = 0.379; - v6_Keq6 = 10; - v6_Ki6Suc6P = 0.07; - v6_Km6F6P = 0.6; - v6_Ki6Pi = 3; - v6_Ki6UDPGlc = 1.4; - v6_Km6UDPGlc = 1.8; - v6_Vmax6r = 0.2; - v6_Km6UDP = 0.3; - v6_Km6Suc6P = 0.1; - v6_Ki6F6P = 0.4; - v7_Vmax7 = 0.5; - v7_Km7Suc6P = 0.1; - v8_Vmax8f = 0.677; - v8_Keq8 = 5; - v8_Ki8Fru = 4; - v8_Km8Suc = 50; - v8_Ki8UDP = 0.3; - v8_Km8UDP = 0.3; - v8_Vmax8r = 0.3; - v8_Km8UDPGlc = 0.3; - v8_Km8Fru = 4; - v8_Ki8Suc = 40; - v9_Vmax9 = 0.372; - v9_Ki9Glc = 15; - v9_Km9Suc = 10; - v9_Ki9Fru = 15; - v10_Vmax10 = 0.1; - v10_Km10F6P = 0.2; - v11_Vmax11 = 1; - v11_Km11Suc = 100; - - // Other declarations: - const compartment_; - - // Unit definitions: - unit substance = 1e-3 mole; - unit time_unit = 60 second; - - // Display Names: - substance is "millimole (default)"; - time_unit is "minute (default)"; - compartment_ is "cell"; - - // CV terms: - compartment_ identity "http://identifiers.org/obo.go/GO:0005623" - Fru identity "http://identifiers.org/obo.chebi/CHEBI:15824", - "http://identifiers.org/kegg.compound/C00095" - Glc identity "http://identifiers.org/obo.chebi/CHEBI:17634", - "http://identifiers.org/kegg.compound/C00031" - HexP version "http://identifiers.org/obo.chebi/CHEBI:16218", - "http://identifiers.org/obo.chebi/CHEBI:15946", - "http://identifiers.org/obo.chebi/CHEBI:14314" - HexP version "http://identifiers.org/kegg.compound/C00029", - "http://identifiers.org/kegg.compound/C00668", - "http://identifiers.org/kegg.compound/C00085", - "http://identifiers.org/kegg.compound/C00103", - "http://identifiers.org/chebi/CHEBI:18066" - Suc6P identity "http://identifiers.org/obo.chebi/CHEBI:16308", - "http://identifiers.org/kegg.compound/C02591" - Suc identity "http://identifiers.org/obo.chebi/CHEBI:17992", - "http://identifiers.org/kegg.compound/C00089" - Sucvac identity "http://identifiers.org/obo.chebi/CHEBI:17992", - "http://identifiers.org/kegg.compound/C00089" - glycolysis identity "http://identifiers.org/kegg.compound/C05378", - "http://identifiers.org/chebi/CHEBI:28013" - phos identity "http://identifiers.org/obo.chebi/CHEBI:18367", - "http://identifiers.org/kegg.compound/C00009" - UDP identity "http://identifiers.org/obo.chebi/CHEBI:17659", - "http://identifiers.org/kegg.compound/C00015" - ADP identity "http://identifiers.org/obo.chebi/CHEBI:16761", - "http://identifiers.org/kegg.compound/C00008" - ATP identity "http://identifiers.org/obo.chebi/CHEBI:15422", - "http://identifiers.org/kegg.compound/C00002" - Glcex identity "http://identifiers.org/obo.chebi/CHEBI:17634", - "http://identifiers.org/kegg.compound/C00031" - Fruex identity "http://identifiers.org/obo.chebi/CHEBI:15824", - "http://identifiers.org/kegg.compound/C00095" - v1 hypernym "http://identifiers.org/obo.go/GO:0015755" - v2 hypernym "http://identifiers.org/obo.go/GO:0015758" - v3 hypernym "http://identifiers.org/ec-code/2.7.1.2" - v3 identity "http://identifiers.org/kegg.reaction/R00299" - v4 hypernym "http://identifiers.org/ec-code/2.7.1.4" - v4 identity "http://identifiers.org/kegg.reaction/R03920", - "http://identifiers.org/kegg.reaction/R00760" - v5 hypernym "http://identifiers.org/ec-code/2.7.1.4" - v5 identity "http://identifiers.org/kegg.reaction/R00760" - v6 hypernym "http://identifiers.org/ec-code/2.4.1.14" - v6 identity "http://identifiers.org/kegg.reaction/R00766" - v7 hypernym "http://identifiers.org/ec-code/3.1.3.24" - v7 identity "http://identifiers.org/kegg.reaction/R00805" - v8 hypernym "http://identifiers.org/ec-code/2.4.1.13" - v8 identity "http://identifiers.org/kegg.reaction/R00806" - v9 hypernym "http://identifiers.org/ec-code/3.2.1.26", - "http://identifiers.org/ec-code/3.2.1.48", - "http://identifiers.org/ec-code/3.2.1.20" - v9 identity "http://identifiers.org/kegg.reaction/R00802" - v10 hypernym "http://identifiers.org/obo.go/GO:0006096" - v11 hypernym "http://identifiers.org/obo.go/GO:0015770" -end - -Rohwer2001_Sucrose is "Rohwer2001_Sucrose" - -Rohwer2001_Sucrose model_entity_is "http://identifiers.org/biomodels.db/MODEL6618063111" -Rohwer2001_Sucrose model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000023" -Rohwer2001_Sucrose description "http://identifiers.org/pubmed/11513743" -Rohwer2001_Sucrose taxon "http://identifiers.org/taxonomy/4547" -Rohwer2001_Sucrose hypernym "http://identifiers.org/obo.go/GO:0005986" -Rohwer2001_Sucrose identity "http://identifiers.org/kegg.pathway/map00500" diff --git a/BioModelsRAG/data/BIOMD0000000024.txt b/BioModelsRAG/data/BIOMD0000000024.txt deleted file mode 100644 index 49fe4559947c21a4f811e2f5ba4cb38c7a120c09..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000024.txt +++ /dev/null @@ -1,67 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Scheper1999() - - // Compartments and Species: - compartment compartment_0000004; - species $EmptySet in compartment_0000004, M in compartment_0000004, P in compartment_0000004; - - // Reactions: - TC: $EmptySet => M; compartment_0000004*(TC_rM/(1 + (P/TC_k)^TC_n)); - TL: $EmptySet => P; compartment_0000004*TL_rP*delay(M, TL_parameter_0000009)^TL_m; - Md: M => $EmptySet; compartment_0000004*Md_qM*M; - Pd: P => $EmptySet; compartment_0000004*Pd_qP*P; - - // Species initializations: - EmptySet = 0; - M = 1e-15/compartment_0000004; - P = 1e-15/compartment_0000004; - - // Compartment initializations: - compartment_0000004 = 1e-15; - - // Variable initializations: - TC_rM = 1; - TC_k = 1; - TC_n = 2; - TL_rP = 1; - TL_m = 3; - TL_parameter_0000009 = 4; - Md_qM = 0.21; - Pd_qP = 0.21; - - // Other declarations: - const compartment_0000004; - - // Unit definitions: - unit time_unit = 3600 second; - - // Display Names: - compartment_0000004 is "cytoplasm"; - M is "mRNA"; - P is "protein"; - TC is "mRNA production"; - TL is "protein production"; - Md is "messenger degradation"; - Pd is "protein degradation"; - - // CV terms: - compartment_0000004 identity "http://identifiers.org/go/GO:0005737" - M hypernym "http://identifiers.org/chebi/CHEBI:33699", - "http://identifiers.org/kegg.compound/C00046" - P identity "http://identifiers.org/kegg.compound/C00017", - "http://identifiers.org/chebi/CHEBI:16541" - TC hypernym "http://identifiers.org/go/GO:0009299" - TL hypernym "http://identifiers.org/go/GO:0006412" - Md hypernym "http://identifiers.org/go/GO:0006402" - Pd hypernym "http://identifiers.org/go/GO:0030163" -end - -Scheper1999 is "Scheper1999_CircClock" - -Scheper1999 model_entity_is "http://identifiers.org/biomodels.db/MODEL6618241436" -Scheper1999 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000024" -Scheper1999 description "http://identifiers.org/pubmed/9870936" -Scheper1999 taxon "http://identifiers.org/taxonomy/10036", - "http://identifiers.org/taxonomy/7227" -Scheper1999 identity "http://identifiers.org/kegg.pathway/dme04711" -Scheper1999 hypernym "http://identifiers.org/go/GO:0042752" diff --git a/BioModelsRAG/data/BIOMD0000000025.txt b/BioModelsRAG/data/BIOMD0000000025.txt deleted file mode 100644 index c171b0b3c461b4771546ff6398e25bd084d6393b..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000025.txt +++ /dev/null @@ -1,87 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Smolen2002() - - // Compartments and Species: - compartment CELL; - species $EmptySet in CELL, Per in CELL, dClk in CELL, $dClkF in CELL; - - // Assignment Rules: - dClkF := piecewise(0, (dClk - Per) < 0, dClk - Per); - dClkF_tau1 := piecewise(0, (delay(dClk, tau1) - delay(Per, tau1)) < 0, delay(dClk, tau1) - delay(Per, tau1)); - dClkF_tau2 := piecewise(0, (delay(dClk, tau2) - delay(Per, tau2)) < 0, delay(dClk, tau2) - delay(Per, tau2)); - - // Reactions: - rPer: $EmptySet => Per; Vsp*(dClkF_tau1/(K1 + dClkF_tau1))*CELL; - rdClk: $EmptySet => dClk; CELL*Vsc*(K2/(K2 + dClkF_tau2)); - rPerD: Per => $EmptySet; kdc*Per*CELL; - rdClkD: dClk => $EmptySet; kdp*dClk*CELL; - - // Species initializations: - EmptySet = 0; - Per = 5e-16; - dClk = 1e-16; - - // Compartment initializations: - CELL = 1e-15; - dClkF_tau1 has nM; - - // Variable initializations: - tau1 = 10; - tau1 has time_unit; - dClkF_tau2 has nM; - tau2 = 10; - tau2 has time_unit; - Vsp = 0.5; - Vsp has nM_per_hr; - K1 = 0.3; - K1 has nM; - Vsc = 0.25; - Vsc has nM_per_hr; - K2 = 0.1; - K2 has nM; - kdc = 0.5; - kdc has per_hr; - kdp = 0.5; - kdp has per_hr; - - // Other declarations: - var dClkF_tau1, dClkF_tau2; - const CELL, tau1, tau2, Vsp, K1, Vsc, K2, kdc, kdp; - - // Unit definitions: - unit time_unit = 3600 second; - unit substance = 1e-9 mole; - unit nM = 1e-9 mole / litre; - unit nM_per_hr = 1e-9 mole / (litre * 3600 second); - unit per_hr = 1 / 3600 second; - - // Display Names: - time_unit is "hour (new default)"; - substance is "nanomole (new default)"; - dClkF is "free dClk"; - rPer is "Per production"; - rdClk is "dClk production"; - rPerD is "Per degradation"; - rdClkD is "dClk degradation"; - - // CV terms: - CELL identity "http://identifiers.org/go/GO:0005623" - Per identity "http://identifiers.org/uniprot/P07663" - dClk part "http://identifiers.org/uniprot/P07663", - "http://identifiers.org/uniprot/O61735" - dClkF identity "http://identifiers.org/uniprot/O61735" - rPer hypernym "http://identifiers.org/go/GO:0006412" - rdClk hypernym "http://identifiers.org/go/GO:0006412" - rPerD hypernym "http://identifiers.org/go/GO:0030163" - rdClkD hypernym "http://identifiers.org/go/GO:0030163" -end - -Smolen2002 is "Smolen2002_CircClock" - -Smolen2002 model_entity_is "http://identifiers.org/biomodels.db/MODEL6618294363" -Smolen2002 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000025" -Smolen2002 description "http://identifiers.org/pubmed/12414672" -Smolen2002 origin "http://identifiers.org/pubmed/11517254" -Smolen2002 taxon "http://identifiers.org/taxonomy/7227" -Smolen2002 identity "http://identifiers.org/kegg.pathway/dme04710" -Smolen2002 hypernym "http://identifiers.org/go/GO:0032922" diff --git a/BioModelsRAG/data/BIOMD0000000026.txt b/BioModelsRAG/data/BIOMD0000000026.txt deleted file mode 100644 index 5bda92c6f7f4178f847255bebb767a0de7a25abb..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000026.txt +++ /dev/null @@ -1,135 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Markevich2004_MAPK_orderedelementary() - - // Compartments and Species: - compartment uVol; - species M in uVol, Mp in uVol, Mpp in uVol, MAPKK in uVol, MKP3 in uVol; - species M_MAPKK in uVol, Mp_MAPKK in uVol, Mpp_MKP3 in uVol, Mp_MKP3_dep in uVol; - species Mp_MKP3 in uVol, M_MKP3 in uVol; - - // Reactions: - v1a: M + MAPKK -> M_MAPKK; uVol*(k1*M*MAPKK - k_1*M_MAPKK); - v1b: M_MAPKK => Mp + MAPKK; uVol*k2*M_MAPKK; - v2a: Mp + MAPKK -> Mp_MAPKK; uVol*(k3*Mp*MAPKK - k_3*Mp_MAPKK); - v2b: Mp_MAPKK => Mpp + MAPKK; uVol*k4*Mp_MAPKK; - v3a: Mpp + MKP3 -> Mpp_MKP3; uVol*(h1*Mpp*MKP3 - h_1*Mpp_MKP3); - v3b: Mpp_MKP3 => Mp_MKP3_dep; uVol*h2*Mpp_MKP3; - v3c: Mp_MKP3_dep -> Mp + MKP3; h3*Mp_MKP3_dep - h_3*Mp*MKP3; - v4a: Mp + MKP3 -> Mp_MKP3; uVol*(h4*Mp*MKP3 - h_4*Mp_MKP3); - v4b: Mp_MKP3 => M_MKP3; uVol*h5*Mp_MKP3; - v4c: M_MKP3 -> M + MKP3; uVol*(h6*M_MKP3 - h_6*M*MKP3); - - // Species initializations: - M = 500/uVol; - Mp = 0; - Mpp = 0; - MAPKK = 50/uVol; - MKP3 = 100/uVol; - M_MAPKK = 0; - Mp_MAPKK = 0; - Mpp_MKP3 = 0; - Mp_MKP3_dep = 0; - Mp_MKP3 = 0; - M_MKP3 = 0; - - // Compartment initializations: - uVol = 1; - - // Variable initializations: - k1 = 0.02; - k_1 = 1; - k2 = 0.01; - k3 = 0.032; - k_3 = 1; - k4 = 15; - h1 = 0.045; - h_1 = 1; - h2 = 0.092; - h3 = 1; - h_3 = 0.01; - h4 = 0.01; - h_4 = 1; - h5 = 0.5; - h6 = 0.086; - h_6 = 0.0011; - - // Other declarations: - const uVol, k1, k_1, k2, k3, k_3, k4, h1, h_1, h2, h3, h_3, h4, h_4, h5; - const h6, h_6; - - // Unit definitions: - unit substance = 1e-9 mole; - - // Display Names: - substance is "nanomole (default)"; - MKP3 is "MKP"; - Mpp_MKP3 is "Mpp_MKP"; - Mp_MKP3_dep is "Mp_MKP"; - Mp_MKP3 is "Mp_MKP*"; - M_MKP3 is "M_MKP"; - v1a is "binding MAPK and PP-MAPKK"; - v1b is "phosphorylation of MAPK"; - v2a is "binding PP-MAPKK and P-MAPK"; - v2b is "phosphorylation of P-MAPK"; - v3a is "binding MKP and PP-MAPK"; - v3b is "dephosphorylation of PP-MAPK"; - v3c is "dissociation of MKP from P-MAPK"; - v4a is "binding MKP and P-MAPK"; - v4b is "dephosphorylation of P-MAPK"; - v4c is "dissociation of MKP from MAPK"; - - // CV terms: - M hypernym "http://identifiers.org/uniprot/P26696" - Mp hypernym "http://identifiers.org/uniprot/P26696" - Mpp hypernym "http://identifiers.org/uniprot/P26696" - MAPKK identity "http://identifiers.org/uniprot/Q05116" - MKP3 identity "http://identifiers.org/uniprot/Q90W58" - M_MAPKK part "http://identifiers.org/uniprot/P26696", - "http://identifiers.org/uniprot/Q05116" - Mp_MAPKK part "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - Mpp_MKP3 part "http://identifiers.org/uniprot/Q90W58", - "http://identifiers.org/uniprot/P26696" - Mp_MKP3_dep part "http://identifiers.org/uniprot/Q90W58", - "http://identifiers.org/uniprot/P26696" - Mp_MKP3 part "http://identifiers.org/uniprot/Q90W58", - "http://identifiers.org/uniprot/P26696" - M_MKP3 part "http://identifiers.org/uniprot/Q90W58", - "http://identifiers.org/uniprot/P26696" - v1a hypernym "http://identifiers.org/obo.go/GO:0031434", - "http://identifiers.org/obo.go/GO:0051019" - v1a homolog "http://identifiers.org/reactome/REACT_1780", - "http://identifiers.org/reactome/REACT_495" - v1b hypernym "http://identifiers.org/ec-code/2.7.12.2", - "http://identifiers.org/obo.go/GO:0006468", - "http://identifiers.org/obo.go/GO:0004708" - v1b homolog "http://identifiers.org/reactome/REACT_136", - "http://identifiers.org/reactome/REACT_2247" - v2a hypernym "http://identifiers.org/obo.go/GO:0031434", - "http://identifiers.org/obo.go/GO:0051019" - v2a homolog "http://identifiers.org/reactome/REACT_1780", - "http://identifiers.org/reactome/REACT_495" - v2b hypernym "http://identifiers.org/ec-code/2.7.12.2", - "http://identifiers.org/obo.go/GO:0000187", - "http://identifiers.org/obo.go/GO:0006468", - "http://identifiers.org/obo.go/GO:0004708" - v2b homolog "http://identifiers.org/reactome/REACT_136", - "http://identifiers.org/reactome/REACT_2247" - v3a hypernym "http://identifiers.org/obo.go/GO:0031434", - "http://identifiers.org/obo.go/GO:0051019" - v3b hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/obo.go/GO:0000188", - "http://identifiers.org/obo.go/GO:0006470" - v3c hypernym "http://identifiers.org/obo.go/GO:0043241" - v4a hypernym "http://identifiers.org/obo.go/GO:0051019" - v4b hypernym "http://identifiers.org/ec-code/3.1.3.16" - v4c hypernym "http://identifiers.org/obo.go/GO:0043241" -end - -Markevich2004_MAPK_orderedelementary is "Markevich2004_MAPK_orderedElementary" - -Markevich2004_MAPK_orderedelementary model_entity_is "http://identifiers.org/biomodels.db/MODEL6618379269" -Markevich2004_MAPK_orderedelementary model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000026" -Markevich2004_MAPK_orderedelementary description "http://identifiers.org/pubmed/14744999" -Markevich2004_MAPK_orderedelementary taxon "http://identifiers.org/taxonomy/8355" -Markevich2004_MAPK_orderedelementary hypernym "http://identifiers.org/obo.go/GO:0000165" diff --git a/BioModelsRAG/data/BIOMD0000000027.txt b/BioModelsRAG/data/BIOMD0000000027.txt deleted file mode 100644 index 9612e64794de2e48342af42dd590704be8d4cfb4..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000027.txt +++ /dev/null @@ -1,78 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Markevich2004_MAPK_orderedMM() - - // Compartments and Species: - compartment uVol; - species M in uVol, Mp in uVol, Mpp in uVol, $MAPKK in uVol, $MKP3 in uVol; - - // Reactions: - v1: M => Mp; uVol*(k1cat*MAPKK*M/Km1/(1 + M/Km1 + Mp/Km2)); - v2: Mp => Mpp; uVol*(k2cat*MAPKK*Mp/Km2/(1 + M/Km1 + Mp/Km2)); - v3: Mpp => Mp; uVol*(k3cat*MKP3*Mpp/Km3/(1 + Mpp/Km3 + Mp/Km4 + M/Km5)); - v4: Mp => M; uVol*(k4cat*MKP3*Mp/Km4/(1 + Mpp/Km3 + Mp/Km4 + M/Km5)); - - // Species initializations: - M = 500/uVol; - Mp = 0; - Mpp = 0; - MAPKK = 50/uVol; - MKP3 = 100/uVol; - - // Compartment initializations: - uVol = 1; - - // Variable initializations: - k1cat = 0.01; - Km1 = 50; - k2cat = 15; - Km2 = 500; - k3cat = 0.084; - Km3 = 22; - k4cat = 0.06; - Km4 = 18; - Km5 = 78; - - // Other declarations: - const uVol, k1cat, Km1, k2cat, Km2, k3cat, Km3, k4cat, Km4, Km5; - - // Unit definitions: - unit substance = 1e-9 mole; - - // Display Names: - substance is "nanomole (default)"; - v1 is "phosphorylation of MAPK"; - v2 is "phosphorylation of P-MAPK"; - v3 is "dephosphorylation of PP-MAPK"; - v4 is "dephosphorylation of P-MAPK"; - - // CV terms: - M hypernym "http://identifiers.org/uniprot/P26696" - Mp hypernym "http://identifiers.org/uniprot/P26696" - Mpp hypernym "http://identifiers.org/uniprot/P26696" - MAPKK identity "http://identifiers.org/uniprot/Q05116" - MKP3 identity "http://identifiers.org/uniprot/Q90W58" - v1 homolog "http://identifiers.org/reactome/REACT_2247", - "http://identifiers.org/reactome/REACT_136" - v1 hypernym "http://identifiers.org/ec-code/2.7.12.2", - "http://identifiers.org/go/GO:0004708", - "http://identifiers.org/go/GO:0006468" - v2 homolog "http://identifiers.org/reactome/REACT_136", - "http://identifiers.org/reactome/REACT_2247" - v2 hypernym "http://identifiers.org/ec-code/2.7.12.2", - "http://identifiers.org/go/GO:0004708", - "http://identifiers.org/go/GO:0000187", - "http://identifiers.org/go/GO:0006468" - v3 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0000188", - "http://identifiers.org/go/GO:0006470" - v4 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0006470" -end - -Markevich2004_MAPK_orderedMM is "Markevich2004 - MAPK double phosphorylation, ordered Michaelis-Menton" - -Markevich2004_MAPK_orderedMM model_entity_is "http://identifiers.org/biomodels.db/MODEL6618496308" -Markevich2004_MAPK_orderedMM model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000027" -Markevich2004_MAPK_orderedMM description "http://identifiers.org/pubmed/14744999" -Markevich2004_MAPK_orderedMM hypernym "http://identifiers.org/go/GO:0000165" -Markevich2004_MAPK_orderedMM taxon "http://identifiers.org/taxonomy/8355" diff --git a/BioModelsRAG/data/BIOMD0000000028.txt b/BioModelsRAG/data/BIOMD0000000028.txt deleted file mode 100644 index 6582c32fcd822279d26f31f4407eaf9791884ab6..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000028.txt +++ /dev/null @@ -1,208 +0,0 @@ -// Created by libAntimony v2.13.0 -model *model_0000001() - - // Compartments and Species: - compartment cell; - species M in cell, MpY in cell, MpT in cell, Mpp in cell, MEK in cell, MKP3 in cell; - species MpY_MEK in cell, MpT_MEK in cell, M_MEK_Y in cell, M_MEK_T in cell; - species Mpp_MKP3 in cell, MpY_MKP3 in cell, MpT_MKP3_Y in cell, MpT_MKP3_T in cell; - species M_MKP3_T in cell, M_MKP3_Y in cell; - - // Reactions: - reaction_0000001: M + MEK -> M_MEK_Y; cell*(k1*M*MEK - k_1*M_MEK_Y); - reaction_0000002: M_MEK_Y => MpY + MEK; cell*k2*M_MEK_Y; - reaction_0000003: MpY + MEK -> MpY_MEK; cell*(k3*MpY*MEK - k_3*MpY_MEK); - reaction_0000004: MpY_MEK => Mpp + MEK; cell*k4*MpY_MEK; - reaction_0000005: M + MEK -> M_MEK_T; cell*(k5*M*MEK - k_5*M_MEK_T); - reaction_0000006: M_MEK_T => MpT + MEK; cell*k6*M_MEK_T; - reaction_0000007: MpT + MEK -> MpT_MEK; cell*(k7*MpT*MEK - k_7*MpT_MEK); - reaction_0000008: MpT_MEK => Mpp + MEK; cell*k8*MpT_MEK; - reaction_0000009: Mpp + MKP3 -> Mpp_MKP3; cell*(h1*Mpp*MKP3 - h_1*Mpp_MKP3); - reaction_0000010: Mpp_MKP3 => MpT_MKP3_Y; cell*h2*Mpp_MKP3; - reaction_0000011: MpT_MKP3_Y -> MpT + MKP3; cell*(h3*MpT_MKP3_Y - h_3*MpT*MKP3); - reaction_0000012: MpT_MKP3_T => M_MKP3_T; cell*h5*MpT_MKP3_T; - reaction_0000013: MpT + MKP3 -> MpT_MKP3_T; cell*(h4*MpT*MKP3 - h_4*MpT_MKP3_T); - reaction_0000014: MpY_MKP3 => M_MKP3_Y; cell*h8*MpY_MKP3; - reaction_0000015: M_MKP3_T -> M + MKP3; cell*(h6*M_MKP3_T - h_6*M*MKP3); - reaction_0000017: MpY + MKP3 -> MpY_MKP3; cell*(h7*MpY*MKP3 - h_7*MpY_MKP3); - reaction_0000019: M_MKP3_Y -> M + MKP3; cell*(h9*M_MKP3_Y - h_9*M*MKP3); - - // Species initializations: - M = 800; - MpY = 0; - MpT = 0; - Mpp = 0; - MEK = 180; - MKP3 = 100; - MpY_MEK = 0; - MpT_MEK = 0; - M_MEK_Y = 0; - M_MEK_T = 0; - Mpp_MKP3 = 0; - MpY_MKP3 = 0; - MpT_MKP3_Y = 0; - MpT_MKP3_T = 0; - M_MKP3_T = 0; - M_MKP3_Y = 0; - - // Compartment initializations: - cell = 1; - - // Variable initializations: - k1 = 0.005; - k_1 = 1; - k2 = 1.08; - k3 = 0.025; - k_3 = 1; - k4 = 0.007; - k5 = 0.05; - k_5 = 1; - k6 = 0.008; - k7 = 0.005; - k_7 = 1; - k8 = 0.45; - h1 = 0.045; - h_1 = 1; - h2 = 0.092; - h3 = 1; - h_3 = 0.01; - h4 = 0.01; - h_4 = 1; - h5 = 0.5; - h6 = 0.086; - h_6 = 0.0011; - h7 = 0.01; - h_7 = 1; - h8 = 0.47; - h9 = 0.14; - h_9 = 0.0018; - - // Other declarations: - const cell, k1, k_1, k2, k3, k_3, k4, k5, k_5, k6, k7, k_7, k8, h1, h_1; - const h2, h3, h_3, h4, h_4, h5, h6, h_6, h7, h_7, h8, h9, h_9; - - // Unit definitions: - unit substance = 1e-9 mole; - - // Display Names: - substance is "nanomole (default)"; - M is "ERK"; - MpY is "ERK-PY"; - MpT is "ERK-PT"; - Mpp is "ERK-PP"; - MpY_MEK is "ERK-PY_MEK"; - MpT_MEK is "ERK-PT_MEK"; - M_MEK_Y is "ERK_MEK_Y"; - M_MEK_T is "ERK_MEK_T"; - Mpp_MKP3 is "ERK-PP_MKP3"; - MpY_MKP3 is "ERK-PY_MKP3"; - MpT_MKP3_Y is "ERK-PT_MKP3_Y"; - MpT_MKP3_T is "ERK-PT_MKP3_T"; - M_MKP3_T is "ERK_MKP3_T"; - M_MKP3_Y is "ERK_MKP3_Y"; - reaction_0000001 is "binding ERK and MEK"; - reaction_0000002 is "tyr phosphorylation of ERK"; - reaction_0000003 is "binding ERK-PY and MEK"; - reaction_0000004 is "thr phosphorylation of ERK"; - reaction_0000005 is "binding ERK and MEK"; - reaction_0000006 is "thr phosphorylation of ERK"; - reaction_0000007 is "binding ERK-PT and MEK"; - reaction_0000008 is "tyr phosphorylation of ERK"; - reaction_0000009 is "binding ERK-PP and MKP3"; - reaction_0000010 is "dephosphorylation of tyr on ERK-PP"; - reaction_0000011 is "dissociation ERK-PT and MKP3"; - reaction_0000012 is "dephosphorylation of ERK-PT"; - reaction_0000013 is "binding ERK-PT and MKP3"; - reaction_0000014 is "dephosphorylation of ERK-PY"; - reaction_0000015 is "dissociation ERK and MKP3"; - reaction_0000017 is "binding ERK-PY and MKP3"; - reaction_0000019 is "Dissociation ERK and MKP3"; - - // CV terms: - cell identity "http://identifiers.org/obo.go/GO:0005623" - M hypernym "http://identifiers.org/uniprot/P26696" - MpY hypernym "http://identifiers.org/uniprot/P26696" - MpT hypernym "http://identifiers.org/uniprot/P26696" - Mpp hypernym "http://identifiers.org/uniprot/P26696" - MEK identity "http://identifiers.org/uniprot/Q05116" - MKP3 identity "http://identifiers.org/uniprot/Q90W58" - MpY_MEK part "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - MpT_MEK part "http://identifiers.org/uniprot/P26696", - "http://identifiers.org/uniprot/Q05116" - M_MEK_Y part "http://identifiers.org/uniprot/P26696", - "http://identifiers.org/uniprot/Q05116" - M_MEK_T part "http://identifiers.org/uniprot/P26696", - "http://identifiers.org/uniprot/Q05116" - Mpp_MKP3 part "http://identifiers.org/uniprot/P26696", - "http://identifiers.org/uniprot/Q90W58" - MpY_MKP3 part "http://identifiers.org/uniprot/P26696", - "http://identifiers.org/uniprot/Q90W58" - MpT_MKP3_Y part "http://identifiers.org/uniprot/P26696", - "http://identifiers.org/uniprot/Q90W58" - MpT_MKP3_T part "http://identifiers.org/uniprot/P26696", - "http://identifiers.org/uniprot/Q90W58" - M_MKP3_T part "http://identifiers.org/uniprot/P26696", - "http://identifiers.org/uniprot/Q90W58" - M_MKP3_Y part "http://identifiers.org/uniprot/Q90W58", - "http://identifiers.org/uniprot/P26696" - reaction_0000001 homolog "http://identifiers.org/reactome/REACT_495", - "http://identifiers.org/reactome/REACT_1780" - reaction_0000001 hypernym "http://identifiers.org/obo.go/GO:0051019", - "http://identifiers.org/obo.go/GO:0031434" - reaction_0000002 homolog "http://identifiers.org/reactome/REACT_2247", - "http://identifiers.org/reactome/REACT_136" - reaction_0000002 hypernym "http://identifiers.org/ec-code/2.7.12.2", - "http://identifiers.org/obo.go/GO:0018108", - "http://identifiers.org/obo.go/GO:0004708" - reaction_0000003 homolog "http://identifiers.org/reactome/REACT_495", - "http://identifiers.org/reactome/REACT_1780" - reaction_0000003 hypernym "http://identifiers.org/obo.go/GO:0051019", - "http://identifiers.org/obo.go/GO:0031434" - reaction_0000004 homolog "http://identifiers.org/reactome/REACT_2247", - "http://identifiers.org/reactome/REACT_136" - reaction_0000004 hypernym "http://identifiers.org/ec-code/2.7.12.2", - "http://identifiers.org/obo.go/GO:0004708", - "http://identifiers.org/obo.go/GO:0018107", - "http://identifiers.org/obo.go/GO:0000187" - reaction_0000005 homolog "http://identifiers.org/reactome/REACT_495", - "http://identifiers.org/reactome/REACT_1780" - reaction_0000005 hypernym "http://identifiers.org/obo.go/GO:0051019", - "http://identifiers.org/obo.go/GO:0031434" - reaction_0000006 homolog "http://identifiers.org/reactome/REACT_2247", - "http://identifiers.org/reactome/REACT_136" - reaction_0000006 hypernym "http://identifiers.org/ec-code/2.7.12.2", - "http://identifiers.org/obo.go/GO:0018107", - "http://identifiers.org/obo.go/GO:0004708" - reaction_0000007 homolog "http://identifiers.org/reactome/REACT_1780", - "http://identifiers.org/reactome/REACT_495" - reaction_0000007 hypernym "http://identifiers.org/obo.go/GO:0051019", - "http://identifiers.org/obo.go/GO:0031434" - reaction_0000008 homolog "http://identifiers.org/reactome/REACT_2247", - "http://identifiers.org/reactome/REACT_136" - reaction_0000008 hypernym "http://identifiers.org/ec-code/2.7.12.2", - "http://identifiers.org/obo.go/GO:0000187", - "http://identifiers.org/obo.go/GO:0018108", - "http://identifiers.org/obo.go/GO:0004708" - reaction_0000009 hypernym "http://identifiers.org/obo.go/GO:0051019" - reaction_0000010 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/obo.go/GO:0006470", - "http://identifiers.org/obo.go/GO:0000188" - reaction_0000011 hypernym "http://identifiers.org/obo.go/GO:0043241" - reaction_0000012 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/obo.go/GO:0006470" - reaction_0000013 hypernym "http://identifiers.org/obo.go/GO:0051019" - reaction_0000014 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/obo.go/GO:0006470" - reaction_0000015 hypernym "http://identifiers.org/obo.go/GO:0043241" - reaction_0000017 hypernym "http://identifiers.org/obo.go/GO:0051019" - reaction_0000019 hypernym "http://identifiers.org/obo.go/GO:0043241" -end - -model_0000001 is "Markevich2004_MAPK_phosphoRandomElementary" - -model_0000001 model_entity_is "http://identifiers.org/biomodels.db/MODEL6618552953" -model_0000001 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000028" -model_0000001 description "http://identifiers.org/pubmed/14744999" -model_0000001 hypernym "http://identifiers.org/obo.go/GO:0000165" -model_0000001 taxon "http://identifiers.org/taxonomy/8355" diff --git a/BioModelsRAG/data/BIOMD0000000029.txt b/BioModelsRAG/data/BIOMD0000000029.txt deleted file mode 100644 index 552a07b398318971b864f2e56438462436f2b7a3..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000029.txt +++ /dev/null @@ -1,112 +0,0 @@ -// Created by libAntimony v2.13.0 -model *model_0000001() - - // Compartments and Species: - compartment cell; - species M in cell, MpY in cell, MpT in cell, Mpp in cell, $MEK in cell; - species $MKP3 in cell; - - // Reactions: - v1: M => MpY; cell*(kcat1*MEK*M/Km1/(1 + M*((Km1 + Km3)/(Km1*Km3)) + MpY/Km2 + MpT/Km4)); - v2: MpY => Mpp; cell*(kcat2*MEK*MpY/Km2/(1 + M*((Km1 + Km3)/(Km1*Km3)) + MpY/Km2 + MpT/Km4)); - v3: M => MpT; cell*(kcat3*MEK*M/Km3/(1 + M*((Km1 + Km3)/(Km1*Km3)) + MpY/Km2 + MpT/Km4)); - v4: MpT => Mpp; cell*(kcat4*MEK*MpT/Km4/(1 + M*((Km1 + Km3)/(Km1*Km3)) + MpY/Km2 + MpT/Km4)); - v5: Mpp => MpT; cell*(kcat5*MKP3*Mpp/Km5/(1 + Mpp/Km5 + MpT/Km6 + MpY/Km7 + M/Km8)); - v6: MpT => M; cell*(kcat6*MKP3*MpT/Km6/(1 + Mpp/Km5 + MpT/Km6 + MpY/Km7 + M/Km8)); - v7: MpY => M; cell*(kcat7*MKP3*MpY/Km7/(1 + Mpp/Km5 + MpT/Km6 + MpY/Km7 + M/Km8)); - - // Species initializations: - M = 800; - MpY = 0; - MpT = 0; - Mpp = 0; - MEK = 180; - MKP3 = 100; - - // Compartment initializations: - cell = 1; - - // Variable initializations: - Km1 = 410; - kcat1 = 1.08; - Km2 = 40; - kcat2 = 0.007; - Km3 = 20; - kcat3 = 0.008; - Km4 = 300; - kcat4 = 0.45; - Km5 = 22; - kcat5 = 0.084; - Km6 = 18; - kcat6 = 0.06; - Km7 = 34; - kcat7 = 0.108; - Km8 = 40; - - // Other declarations: - const cell, Km1, kcat1, Km2, kcat2, Km3, kcat3, Km4, kcat4, Km5, kcat5; - const Km6, kcat6, Km7, kcat7, Km8; - - // Unit definitions: - unit substance = 1e-9 mole; - - // Display Names: - substance is "nanomole (default)"; - M is "ERK"; - MpY is "ERK-PY"; - MpT is "ERK-PT"; - Mpp is "ERK-PP"; - v1 is "phosphorylation of ERK on Tyr"; - v2 is "phosphorylation of ERK-PY on Thr"; - v3 is "phosphorylation of ERK on Thr"; - v4 is "phosphorylation of ERK-PT on Tyr"; - v5 is "dephosphorylation of ERK-PP on Tyr"; - v6 is "dephosphorylation of ERK-PT"; - v7 is "dephosphorylation of ERK-PY"; - - // CV terms: - cell identity "http://identifiers.org/obo.go/GO:0005623" - M hypernym "http://identifiers.org/uniprot/P26696" - MpY hypernym "http://identifiers.org/uniprot/P26696" - MpT hypernym "http://identifiers.org/uniprot/P26696" - Mpp hypernym "http://identifiers.org/uniprot/P26696" - MEK identity "http://identifiers.org/uniprot/Q05116" - MKP3 identity "http://identifiers.org/uniprot/Q90W58" - v1 hypernym "http://identifiers.org/ec-code/2.7.12.2", - "http://identifiers.org/obo.go/GO:0018108", - "http://identifiers.org/obo.go/GO:0004708" - v1 homolog "http://identifiers.org/reactome/REACT_2247", - "http://identifiers.org/reactome/REACT_136" - v2 homolog "http://identifiers.org/reactome/REACT_2247", - "http://identifiers.org/reactome/REACT_136" - v2 hypernym "http://identifiers.org/ec-code/2.7.12.2", - "http://identifiers.org/obo.go/GO:0018107", - "http://identifiers.org/obo.go/GO:0000187", - "http://identifiers.org/obo.go/GO:0004708" - v3 hypernym "http://identifiers.org/ec-code/2.7.12.2", - "http://identifiers.org/obo.go/GO:0018107", - "http://identifiers.org/obo.go/GO:0004708" - v3 homolog "http://identifiers.org/reactome/REACT_2247", - "http://identifiers.org/reactome/REACT_136" - v4 homolog "http://identifiers.org/reactome/REACT_2247", - "http://identifiers.org/reactome/REACT_136" - v4 hypernym "http://identifiers.org/ec-code/2.7.12.2", - "http://identifiers.org/obo.go/GO:0004708", - "http://identifiers.org/obo.go/GO:0000187", - "http://identifiers.org/obo.go/GO:0018108" - v5 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/obo.go/GO:0000188", - "http://identifiers.org/obo.go/GO:0006470" - v6 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/obo.go/GO:0006470" - v7 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/obo.go/GO:0006470" -end - -model_0000001 is "Markevich2004_MAPK_phosphoRandomMM" - -model_0000001 model_entity_is "http://identifiers.org/biomodels.db/MODEL6618620128" -model_0000001 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000029" -model_0000001 description "http://identifiers.org/pubmed/14744999" -model_0000001 hypernym "http://identifiers.org/obo.go/GO:0000165" -model_0000001 taxon "http://identifiers.org/taxonomy/8355" diff --git a/BioModelsRAG/data/BIOMD0000000030.txt b/BioModelsRAG/data/BIOMD0000000030.txt deleted file mode 100644 index 8f46aee8dd8080bff5cc71c52c35429b2e914ab7..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000030.txt +++ /dev/null @@ -1,233 +0,0 @@ -// Created by libAntimony v2.13.0 -model *model_0000001() - - // Compartments and Species: - compartment cell; - species M in cell, MpY in cell, MpT in cell, Mpp in cell, MAPKK in cell; - species MKP in cell, MpY_MAPKK in cell, MpT_MAPKK in cell, M_MAPKK_Y in cell; - species M_MAPKK_T in cell, Mpp_MKP_Y in cell, Mpp_MKP_T in cell, MpY_MKP_Y in cell; - species MpY_MKP_T in cell, MpT_MKP_Y in cell, MpT_MKP_T in cell, M_MKP_T in cell; - species M_MKP_Y in cell; - - // Reactions: - reaction_0000001: M + MAPKK -> M_MAPKK_Y; cell*(k1*M*MAPKK - k_1*M_MAPKK_Y); - reaction_0000002: M_MAPKK_Y => MpY + MAPKK; cell*k2*M_MAPKK_Y; - reaction_0000003: MpY + MAPKK -> MpY_MAPKK; cell*(k3*MpY*MAPKK - k_3*MpY_MAPKK); - reaction_0000004: MpY_MAPKK => Mpp + MAPKK; cell*k4*MpY_MAPKK; - reaction_0000005: M + MAPKK -> M_MAPKK_T; cell*(k5*M*MAPKK - k_5*M_MAPKK_T); - reaction_0000006: M_MAPKK_T => MpT + MAPKK; cell*k6*M_MAPKK_T; - reaction_0000007: MpT + MAPKK -> MpT_MAPKK; cell*(k7*MpT*MAPKK - k_7*MpT_MAPKK); - reaction_0000008: MpT_MAPKK => Mpp + MAPKK; cell*k8*MpT_MAPKK; - reaction_0000009: Mpp + MKP -> Mpp_MKP_Y; cell*(h1*Mpp*MKP - h_1*Mpp_MKP_Y); - reaction_0000010: Mpp_MKP_Y => MpT_MKP_Y; cell*h2*Mpp_MKP_Y; - reaction_0000011: MpT_MKP_Y -> MpT + MKP; cell*(h3*MpT_MKP_Y - h_3*MpT*MKP); - reaction_0000013: MpT + MKP -> MpT_MKP_T; cell*(h4*MpT*MKP - h_4*MpT_MKP_T); - reaction_0000012: MpT_MKP_T => M_MKP_T; cell*h5*MpT_MKP_T; - reaction_0000015: M_MKP_T -> M + MKP; cell*(h6*M_MKP_T - h_6*M*MKP); - reaction_0000017: MpY + MKP -> MpY_MKP_Y; cell*(h7*MpY*MKP - h_7*MpY_MKP_Y); - reaction_0000014: MpY_MKP_Y => M_MKP_Y; cell*h8*MpY_MKP_Y; - reaction_0000019: M_MKP_Y -> M + MKP; cell*(h9*M_MKP_Y - h_9*M*MKP); - reaction_0000020: Mpp + MKP -> Mpp_MKP_T; cell*(h10*Mpp*MKP - h_10*Mpp_MKP_T); - reaction_0000021: Mpp_MKP_T => MpY_MKP_T; cell*h11*Mpp_MKP_T; - reaction_0000022: MpY_MKP_T -> MpY + MKP; cell*(h12*MpY_MKP_T - h_12*MpY*MKP); - - // Species initializations: - M = 800; - MpY = 0; - MpT = 0; - Mpp = 0; - MAPKK = 180; - MKP = 100; - MpY_MAPKK = 0; - MpT_MAPKK = 0; - M_MAPKK_Y = 0; - M_MAPKK_T = 0; - Mpp_MKP_Y = 0; - Mpp_MKP_T = 0; - MpY_MKP_Y = 0; - MpY_MKP_T = 0; - MpT_MKP_Y = 0; - MpT_MKP_T = 0; - M_MKP_T = 0; - M_MKP_Y = 0; - - // Compartment initializations: - cell = 1; - - // Variable initializations: - k1 = 0.02; - k_1 = 1; - k2 = 0.01; - k3 = 0.032; - k_3 = 1; - k4 = 15; - k5 = 0.02; - k_5 = 1; - k6 = 0.01; - k7 = 0.032; - k_7 = 1; - k8 = 15; - h1 = 0.045; - h_1 = 1; - h2 = 0.092; - h3 = 1; - h_3 = 0.01; - h4 = 0.01; - h_4 = 1; - h5 = 0.5; - h6 = 0.086; - h_6 = 0.0011; - h7 = 0.01; - h_7 = 1; - h8 = 0.47; - h9 = 0.14; - h_9 = 0.0018; - h10 = 0.045; - h_10 = 1; - h11 = 0.092; - h12 = 1; - h_12 = 0.01; - - // Other declarations: - const cell, k1, k_1, k2, k3, k_3, k4, k5, k_5, k6, k7, k_7, k8, h1, h_1; - const h2, h3, h_3, h4, h_4, h5, h6, h_6, h7, h_7, h8, h9, h_9, h10, h_10; - const h11, h12, h_12; - - // Unit definitions: - unit substance = 1e-9 mole; - - // Display Names: - substance is "nanomole (default)"; - M is "MAPK"; - MpY is "MAPK-PY"; - MpT is "MAPK-PT"; - Mpp is "MAPK-PP"; - MpY_MAPKK is "MAPK-PY_MAPKK"; - MpT_MAPKK is "MAPK-PT_MAPKK"; - M_MAPKK_Y is "MAPK_MAPKK_Y"; - M_MAPKK_T is "MAPK_MAPKK_T"; - Mpp_MKP_Y is "MAPK-PP_MKP_T"; - Mpp_MKP_T is "MAPK-PP_MKP_Y"; - MpY_MKP_Y is "MAPK-PY_MKP_Y"; - MpY_MKP_T is "MAPK-PY_MKP_T"; - MpT_MKP_Y is "MAPK-PT_MKP_Y"; - MpT_MKP_T is "MAPK-PT_MKP_T"; - M_MKP_T is "MAPK_MKP_T"; - M_MKP_Y is "MAPK_MKP_Y"; - reaction_0000001 is "binding MAPKK on Tyr site of MAPK"; - reaction_0000002 is "tyr phosphorylation of MAPK"; - reaction_0000003 is "binding of MAPKK on MAPK-PY"; - reaction_0000004 is "thr phosphorylation of MAPK"; - reaction_0000005 is "binding of MAPKK on Thr site of MAPK"; - reaction_0000006 is "thr phosphorylation of MAPK"; - reaction_0000007 is "binding MAPK-PT and MAPKK"; - reaction_0000008 is "tyr phosphorylation of MAPK"; - reaction_0000009 is "binding of MKP on Tyr site of MAPK-PP"; - reaction_0000010 is "dephosphorylation of Tyr on MAPKK-PP"; - reaction_0000011 is "dissociation MAPK-PT and MKP"; - reaction_0000013 is "binding of MKP on Thr site of MAPK-PT"; - reaction_0000012 is "dephosphorylation of MAPK-PT"; - reaction_0000015 is "dissociation MAPK and MKP"; - reaction_0000017 is "binding of MKP on the Tyr site of MAPK-PY"; - reaction_0000014 is "dephosphorylation of MAPK-PY"; - reaction_0000019 is "Dissociation MAPK and MKP"; - reaction_0000020 is "binding of MKP on Thr site of MAPK-PP"; - reaction_0000021 is "dephosphorylation of Thr on MAPKK-PP"; - reaction_0000022 is "dissociation MAPK-PY and MKP"; - - // CV terms: - cell identity "http://identifiers.org/obo.go/GO:0005623" - M hypernym "http://identifiers.org/uniprot/P26696" - MpY hypernym "http://identifiers.org/uniprot/P26696" - MpT hypernym "http://identifiers.org/uniprot/P26696" - Mpp hypernym "http://identifiers.org/uniprot/P26696" - MAPKK identity "http://identifiers.org/uniprot/Q05116" - MKP identity "http://identifiers.org/uniprot/Q90W58" - MpY_MAPKK part "http://identifiers.org/uniprot/P26696", - "http://identifiers.org/uniprot/Q05116" - MpT_MAPKK part "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - M_MAPKK_Y part "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - M_MAPKK_T part "http://identifiers.org/uniprot/Q05116", - "http://identifiers.org/uniprot/P26696" - Mpp_MKP_Y part "http://identifiers.org/uniprot/Q90W58", - "http://identifiers.org/uniprot/P26696" - Mpp_MKP_T part "http://identifiers.org/uniprot/Q90W58", - "http://identifiers.org/uniprot/P26696" - MpY_MKP_Y part "http://identifiers.org/uniprot/Q90W58", - "http://identifiers.org/uniprot/P26696" - MpY_MKP_T part "http://identifiers.org/uniprot/Q90W58", - "http://identifiers.org/uniprot/P26696" - MpT_MKP_Y part "http://identifiers.org/uniprot/Q90W58", - "http://identifiers.org/uniprot/P26696" - MpT_MKP_T part "http://identifiers.org/uniprot/Q90W58", - "http://identifiers.org/uniprot/P26696" - M_MKP_T part "http://identifiers.org/uniprot/Q90W58", - "http://identifiers.org/uniprot/P26696" - M_MKP_Y part "http://identifiers.org/uniprot/Q90W58", - "http://identifiers.org/uniprot/P26696" - reaction_0000001 homolog "http://identifiers.org/reactome/REACT_1780", - "http://identifiers.org/reactome/REACT_495" - reaction_0000001 hypernym "http://identifiers.org/obo.go/GO:0031434", - "http://identifiers.org/obo.go/GO:0051019" - reaction_0000002 homolog "http://identifiers.org/reactome/REACT_136", - "http://identifiers.org/reactome/REACT_2247" - reaction_0000002 hypernym "http://identifiers.org/ec-code/2.7.12.2", - "http://identifiers.org/obo.go/GO:0004708", - "http://identifiers.org/obo.go/GO:0018108" - reaction_0000003 homolog "http://identifiers.org/reactome/REACT_1780", - "http://identifiers.org/reactome/REACT_495" - reaction_0000003 hypernym "http://identifiers.org/obo.go/GO:0031434", - "http://identifiers.org/obo.go/GO:0051019" - reaction_0000004 homolog "http://identifiers.org/reactome/REACT_136", - "http://identifiers.org/reactome/REACT_2247" - reaction_0000004 hypernym "http://identifiers.org/ec-code/2.7.12.2", - "http://identifiers.org/obo.go/GO:0004708", - "http://identifiers.org/obo.go/GO:0018107", - "http://identifiers.org/obo.go/GO:0000187" - reaction_0000005 homolog "http://identifiers.org/reactome/REACT_1780", - "http://identifiers.org/reactome/REACT_495" - reaction_0000005 hypernym "http://identifiers.org/obo.go/GO:0031434", - "http://identifiers.org/obo.go/GO:0051019" - reaction_0000006 homolog "http://identifiers.org/reactome/REACT_136", - "http://identifiers.org/reactome/REACT_2247" - reaction_0000006 hypernym "http://identifiers.org/ec-code/2.7.12.2", - "http://identifiers.org/obo.go/GO:0004708", - "http://identifiers.org/obo.go/GO:0018107" - reaction_0000007 homolog "http://identifiers.org/reactome/REACT_1780", - "http://identifiers.org/reactome/REACT_495" - reaction_0000007 hypernym "http://identifiers.org/obo.go/GO:0051019" - reaction_0000008 homolog "http://identifiers.org/reactome/REACT_136", - "http://identifiers.org/reactome/REACT_2247" - reaction_0000008 hypernym "http://identifiers.org/ec-code/2.7.12.2", - "http://identifiers.org/obo.go/GO:0004708", - "http://identifiers.org/obo.go/GO:0018108", - "http://identifiers.org/obo.go/GO:0000187" - reaction_0000009 hypernym "http://identifiers.org/obo.go/GO:0051019" - reaction_0000010 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/obo.go/GO:0000188", - "http://identifiers.org/obo.go/GO:0006470" - reaction_0000011 hypernym "http://identifiers.org/obo.go/GO:0043241" - reaction_0000013 hypernym "http://identifiers.org/obo.go/GO:0051019" - reaction_0000012 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/obo.go/GO:0006470" - reaction_0000015 hypernym "http://identifiers.org/obo.go/GO:0043241" - reaction_0000017 hypernym "http://identifiers.org/obo.go/GO:0051019" - reaction_0000014 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/obo.go/GO:0006470" - reaction_0000019 hypernym "http://identifiers.org/obo.go/GO:0043241" - reaction_0000020 hypernym "http://identifiers.org/obo.go/GO:0051019" - reaction_0000021 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/obo.go/GO:0000188", - "http://identifiers.org/obo.go/GO:0006470" - reaction_0000022 hypernym "http://identifiers.org/obo.go/GO:0043241" -end - -model_0000001 is "Markevich2004_MAPK_AllRandomElementary" - -model_0000001 model_entity_is "http://identifiers.org/biomodels.db/MODEL6618676537" -model_0000001 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000030" -model_0000001 description "http://identifiers.org/pubmed/14744999" -model_0000001 hypernym "http://identifiers.org/obo.go/GO:0000165" -model_0000001 taxon "http://identifiers.org/taxonomy/8355" diff --git a/BioModelsRAG/data/BIOMD0000000031.txt b/BioModelsRAG/data/BIOMD0000000031.txt deleted file mode 100644 index e63907a1b2de689eb72a6b5b875c68c12bec99ad..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000031.txt +++ /dev/null @@ -1,80 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Markevich2004_MAPK_orderedMM2kinases() - - // Compartments and Species: - compartment uVol; - species M in uVol, Mp in uVol, Mpp in uVol, $MAPKK1 in uVol, $MAPKK2 in uVol; - species $MKP3 in uVol; - - // Reactions: - v1: M => Mp; uVol*(k1cat*MAPKK1*M/Km1/(1 + M/Km1)); - v2: Mp => Mpp; uVol*(k2cat*MAPKK2*Mp/Km2/(1 + Mp/Km2)); - v3: Mpp => Mp; uVol*(k3cat*MKP3*Mpp/Km3/(1 + Mpp/Km3 + Mp/Km4 + M/Km5)); - v4: Mp => M; uVol*(k4cat*MKP3*Mp/Km4/(1 + Mpp/Km3 + Mp/Km4 + M/Km5)); - - // Species initializations: - M = 500/uVol; - Mp = 0; - Mpp = 0; - MAPKK1 = 100/uVol; - MAPKK2 = 1/uVol; - MKP3 = 100/uVol; - - // Compartment initializations: - uVol = 1; - - // Variable initializations: - k1cat = 0.01; - Km1 = 50; - k2cat = 15; - Km2 = 500; - k3cat = 0.084; - Km3 = 5; - k4cat = 0.06; - Km4 = 18; - Km5 = 78; - - // Other declarations: - const uVol, k1cat, Km1, k2cat, Km2, k3cat, Km3, k4cat, Km4, Km5; - - // Unit definitions: - unit substance = 1e-9 mole; - - // Display Names: - substance is "nanomole (default)"; - v1 is "phosphorylation of MAPK"; - v2 is "phosphorylation of P-MAPK"; - v3 is "dephosphorylation of PP-MAPK"; - v4 is "dephosphorylation of P-MAPK"; - - // CV terms: - M hypernym "http://identifiers.org/uniprot/P26696" - Mp hypernym "http://identifiers.org/uniprot/P26696" - Mpp hypernym "http://identifiers.org/uniprot/P26696" - MAPKK1 identity "http://identifiers.org/uniprot/Q05116" - MAPKK2 identity "http://identifiers.org/uniprot/Q05116" - MKP3 identity "http://identifiers.org/uniprot/Q90W58" - v1 homolog "http://identifiers.org/reactome/REACT_136", - "http://identifiers.org/reactome/REACT_2247" - v1 hypernym "http://identifiers.org/ec-code/2.7.12.2", - "http://identifiers.org/obo.go/GO:0006468", - "http://identifiers.org/obo.go/GO:0004708" - v2 homolog "http://identifiers.org/reactome/REACT_136", - "http://identifiers.org/reactome/REACT_2247" - v2 hypernym "http://identifiers.org/ec-code/2.7.12.2", - "http://identifiers.org/obo.go/GO:0004708", - "http://identifiers.org/obo.go/GO:0000187" - v3 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/obo.go/GO:0000188", - "http://identifiers.org/obo.go/GO:0006470" - v4 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/obo.go/GO:0006470" -end - -Markevich2004_MAPK_orderedMM2kinases is "Markevich2004_MAPK_orderedMM2kinases" - -Markevich2004_MAPK_orderedMM2kinases model_entity_is "http://identifiers.org/biomodels.db/MODEL6618738800" -Markevich2004_MAPK_orderedMM2kinases model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000031" -Markevich2004_MAPK_orderedMM2kinases description "http://identifiers.org/pubmed/14744999" -Markevich2004_MAPK_orderedMM2kinases hypernym "http://identifiers.org/obo.go/GO:0000165" -Markevich2004_MAPK_orderedMM2kinases taxon "http://identifiers.org/taxonomy/8355" diff --git a/BioModelsRAG/data/BIOMD0000000032.txt b/BioModelsRAG/data/BIOMD0000000032.txt deleted file mode 100644 index d996ed31fc558a75779bf895fd88b3957367f8f8..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000032.txt +++ /dev/null @@ -1,423 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Kofahl2004_PheromonePathway() - - // Compartments and Species: - compartment Extracellular, compartment_; - species alpha in Extracellular, Ste2 in compartment_, Ste2a in compartment_; - species Gabc in compartment_, GaGTP in compartment_, Gbc in compartment_; - species GaGDP in compartment_, complexC in compartment_, complexD in compartment_; - species Ste5 in compartment_, Ste11 in compartment_, complexA in compartment_; - species Ste7 in compartment_, Fus3 in compartment_, complexB in compartment_; - species Ste20 in compartment_, complexE in compartment_, complexF in compartment_; - species complexG in compartment_, complexH in compartment_, complexI in compartment_; - species complexL in compartment_, Fus3PP in compartment_, complexK in compartment_; - species Ste12 in compartment_, Ste12a in compartment_, Bar1 in compartment_; - species Bar1a in compartment_, Bar1aex in Extracellular, Far1 in compartment_; - species Far1PP in compartment_, Far1U in compartment_, complexM in compartment_; - species complexN in compartment_, Cdc28 in compartment_, Sst2 in compartment_; - species $p in compartment_; - - // Reactions: - v1: alpha -> ; Extracellular*alpha*Bar1aex*v1_k1; - v2: Ste2 -> Ste2a; compartment_*Ste2*alpha*v2_k2; - v3: Ste2a -> Ste2; compartment_*Ste2a*v3_k3; - v4: Ste2a -> $p; compartment_*Ste2a*v4_k4; - v5: Ste2 -> ; compartment_*Ste2*v5_k5; - v6: Gabc -> GaGTP + Gbc; compartment_*Ste2a*Gabc*v6_k6; - v7: GaGTP -> GaGDP; compartment_*GaGTP*v7_k7; - v8: GaGTP -> GaGDP; compartment_*GaGTP*Sst2*v8_k8; - v9: GaGDP + Gbc -> Gabc; compartment_*GaGDP*Gbc*v9_k9; - v10: Gbc + complexC -> complexD; compartment_*Gbc*complexC*v10_k10; - v11: complexD -> Gbc + complexC; compartment_*complexD*v11_k11; - v12: Ste11 + Ste5 -> complexA; compartment_*Ste5*Ste11*v12_k12; - v13: complexA -> Ste11 + Ste5; compartment_*complexA*v13_k13; - v14: Fus3 + Ste7 -> complexB; compartment_*Ste7*Fus3*v14_k14; - v15: complexB -> Fus3 + Ste7; compartment_*complexB*v15_k15; - v16: complexA + complexB -> complexC; compartment_*complexA*complexB*v16_k16; - v17: complexC -> Fus3 + Ste11 + Ste7 + Ste5; compartment_*complexC*v17_k17; - v18: complexD + Ste20 -> complexE; compartment_*complexD*Ste20*v18_k18; - v19: complexE -> complexD + Ste20; compartment_*complexE*v19_k19; - v20: complexE -> complexF; compartment_*complexE*v20_k20; - v21: complexE -> Gbc + Ste7 + Ste5 + Fus3 + Ste20 + Ste11; compartment_*complexE*v21_k21; - v22: complexF -> complexG; compartment_*complexF*v22_k22; - v23: complexF -> Gbc + Ste7 + Ste5 + Fus3 + Ste20 + Ste11; compartment_*complexF*v23_k23; - v24: complexG -> complexH; compartment_*complexG*v24_k24; - v25: complexG -> Gbc + Ste7 + Ste5 + Fus3 + Ste20 + Ste11; compartment_*complexG*v25_k25; - v26: complexH -> complexI; compartment_*complexH*v26_k26; - v27: complexH -> Gbc + Ste7 + Ste5 + Fus3 + Ste20 + Ste11; compartment_*complexH*v27_k27; - v28: complexI -> complexL + Fus3PP; compartment_*complexI*v28_k28; - v29: complexL + Fus3 -> complexK; compartment_*complexL*Fus3*v29_k29; - v30: complexK -> complexL + Fus3; compartment_*complexK*v30_k30; - v31: complexK -> complexI; compartment_*complexK*v31_k31; - v32: complexL -> Gbc + Ste7 + Ste5 + Ste20 + Ste11; compartment_*complexL*v32_k32; - v33: Fus3PP -> Fus3; compartment_*Fus3PP*v33_k33; - v34: Ste12 + Fus3PP -> Ste12a; compartment_*Ste12*Fus3PP*v34_k34; - v35: Ste12a -> Ste12 + Fus3PP; compartment_*Ste12a*v35_k35; - v36: Bar1 -> Bar1a; compartment_*Ste12a*Bar1*v36_k36; - v37: Bar1a -> Bar1; compartment_*Bar1a*v37_k37; - v38: Bar1a -> Bar1aex; compartment_*Bar1a*v38_k38; - v39: Far1 -> Far1PP; compartment_*(Far1*Fus3PP*Fus3PP/(100*100 + Fus3PP*Fus3PP))*v39_k39; - v40: Far1PP -> Far1; compartment_*Far1PP*v40_k40; - v41: Far1 -> Far1U; compartment_*Far1*Cdc28*v41_k41; - v42: Gbc + Far1PP -> complexM; compartment_*Gbc*Far1PP*v42_k42; - v43: complexM -> Gbc + Far1PP; compartment_*complexM*v43_k43; - v44: complexN -> Cdc28 + Far1PP; compartment_*complexN*v44_k44; - v45: Cdc28 + Far1PP -> complexN; compartment_*Far1PP*Cdc28*v45_k45; - v46: $p -> Sst2; compartment_*(Fus3PP^2/(4^2 + Fus3PP^2))*v46_k46; - v47: Sst2 -> $p; compartment_*Sst2*v47_k47; - - // Species initializations: - alpha = 100; - Ste2 = 1666.6666667; - Ste2a = 0; - Gabc = 1666.6666667; - GaGTP = 0; - Gbc = 0; - GaGDP = 0; - complexC = 235.724935791903; - complexD = 0; - Ste5 = 158.33176608789; - Ste11 = 158.33176608789; - complexA = 105.943298120207; - Ste7 = 36.3997016405141; - Fus3 = 686.399701640513; - complexB = 77.8753625675829; - Ste20 = 1000; - complexE = 0; - complexF = 0; - complexG = 0; - complexH = 0; - complexI = 0; - complexL = 0; - Fus3PP = 0; - complexK = 0; - Ste12 = 200; - Ste12a = 0; - Bar1 = 200; - Bar1a = 0; - Bar1aex = 0; - Far1 = 500; - Far1PP = 0; - Far1U = 0; - complexM = 0; - complexN = 0; - Cdc28 = 300; - Sst2 = 0; - p = 0; - - // Compartment initializations: - Extracellular = 1; - compartment_ = 1; - - // Variable initializations: - v1_k1 = 0.03; - v1_k1 has min_inv_nM_inv; - v2_k2 = 0.0012; - v2_k2 has min_inv_nM_inv; - v3_k3 = 0.6; - v3_k3 has min_inv; - v4_k4 = 0.24; - v4_k4 has min_inv; - v5_k5 = 0.024; - v5_k5 has min_inv; - v6_k6 = 0.0036; - v6_k6 has min_inv_nM_inv; - v7_k7 = 0.24; - v7_k7 has min_inv; - v8_k8 = 0.033; - v8_k8 has min_inv_nM_inv; - v9_k9 = 2000; - v9_k9 has min_inv_nM_inv; - v10_k10 = 0.1; - v10_k10 has min_inv_nM_inv; - v11_k11 = 5; - v11_k11 has min_inv; - v12_k12 = 1; - v12_k12 has min_inv_nM_inv; - v13_k13 = 3; - v13_k13 has min_inv; - v14_k14 = 1; - v14_k14 has min_inv_nM_inv; - v15_k15 = 3; - v15_k15 has min_inv; - v16_k16 = 3; - v16_k16 has min_inv_nM_inv; - v17_k17 = 100; - v17_k17 has min_inv; - v18_k18 = 5; - v18_k18 has min_inv_nM_inv; - v19_k19 = 1; - v19_k19 has min_inv; - v20_k20 = 10; - v20_k20 has min_inv; - v21_k21 = 5; - v21_k21 has min_inv; - v22_k22 = 47; - v22_k22 has min_inv; - v23_k23 = 5; - v23_k23 has min_inv; - v24_k24 = 345; - v24_k24 has min_inv; - v25_k25 = 5; - v25_k25 has min_inv; - v26_k26 = 50; - v26_k26 has min_inv; - v27_k27 = 5; - v27_k27 has min_inv; - v28_k28 = 140; - v28_k28 has min_inv; - v29_k29 = 10; - v29_k29 has min_inv_nM_inv; - v30_k30 = 1; - v30_k30 has min_inv; - v31_k31 = 250; - v31_k31 has min_inv; - v32_k32 = 5; - v32_k32 has min_inv; - v33_k33 = 50; - v33_k33 has min_inv; - v34_k34 = 18; - v34_k34 has min_inv_nM_inv; - v35_k35 = 10; - v35_k35 has min_inv; - v36_k36 = 0.1; - v36_k36 has min_inv_nM_inv; - v37_k37 = 0.1; - v37_k37 has min_inv; - v38_k38 = 0.01; - v38_k38 has min_inv; - v39_k39 = 18; - v39_k39 has min_inv; - v40_k40 = 1; - v40_k40 has min_inv; - v41_k41 = 0.02; - v41_k41 has min_inv_nM_inv; - v42_k42 = 0.1; - v42_k42 has min_inv_nM_inv; - v43_k43 = 0.01; - v43_k43 has min_inv; - v44_k44 = 0.01; - v44_k44 has min_inv; - v45_k45 = 0.1; - v45_k45 has min_inv_nM_inv; - v46_k46 = 200; - v46_k46 has nM_min_inv; - v47_k47 = 1; - v47_k47 has min_inv; - - // Other declarations: - const Extracellular, compartment_; - - // Unit definitions: - unit substance = 1e-9 mole; - unit time_unit = 60 second; - unit nanoMolar = 1e-9 mole / litre; - unit min_inv = 1 / 60 second; - unit min_inv_nM_inv = litre / (1e-9 mole * 60 second); - unit nM_min_inv = 1e-9 mole / (litre * 60 second); - - // Display Names: - substance is "nanomole (default)"; - time_unit is "minute (default)"; - compartment_ is "cell"; - alpha is "α-factor"; - Ste2a is "Ste2active"; - Gabc is "Gαβγ"; - GaGTP is "GαGTP"; - Gbc is "Gβγ"; - GaGDP is "GαGDP"; - Ste12a is "Ste12active"; - Bar1a is "Bar1active"; - Bar1aex is "Bar1activeEx"; - Far1U is "Far1ubiquitin"; - v1 is "alpha degradation"; - - // CV terms: - Extracellular hypernym "http://identifiers.org/go/GO:0005615" - compartment_ hypernym "http://identifiers.org/go/GO:0005623" - Ste2 identity "http://identifiers.org/uniprot/P06842" - Ste2a identity "http://identifiers.org/uniprot/P06842" - Gabc part "http://identifiers.org/uniprot/P08539", - "http://identifiers.org/uniprot/P18851", - "http://identifiers.org/uniprot/P18852" - GaGTP identity "http://identifiers.org/uniprot/P08539" - Gbc part "http://identifiers.org/uniprot/P18851", - "http://identifiers.org/uniprot/P18852" - Gbc identity "http://identifiers.org/bind/50058" - GaGDP identity "http://identifiers.org/uniprot/P08539" - complexC part "http://identifiers.org/uniprot/P16892", - "http://identifiers.org/uniprot/P23561", - "http://identifiers.org/uniprot/P06784", - "http://identifiers.org/uniprot/P32917" - complexC identity "http://identifiers.org/bind/133390" - complexD part "http://identifiers.org/uniprot/P23561", - "http://identifiers.org/uniprot/P18851", - "http://identifiers.org/uniprot/P32917", - "http://identifiers.org/uniprot/P06784", - "http://identifiers.org/uniprot/P08539", - "http://identifiers.org/uniprot/P16892", - "http://identifiers.org/uniprot/P18852" - Ste5 identity "http://identifiers.org/uniprot/P32917" - Ste11 identity "http://identifiers.org/uniprot/P23561" - complexA part "http://identifiers.org/uniprot/P32917", - "http://identifiers.org/uniprot/P23561" - Ste7 identity "http://identifiers.org/uniprot/P06784" - Fus3 identity "http://identifiers.org/uniprot/P16892" - complexB part "http://identifiers.org/uniprot/P06784", - "http://identifiers.org/uniprot/P16892" - complexB identity "http://identifiers.org/bind/130661" - Ste20 identity "http://identifiers.org/uniprot/Q03497" - complexE part "http://identifiers.org/uniprot/P18852", - "http://identifiers.org/uniprot/P18851", - "http://identifiers.org/uniprot/P08539", - "http://identifiers.org/uniprot/P16892", - "http://identifiers.org/uniprot/P06784", - "http://identifiers.org/uniprot/Q03497", - "http://identifiers.org/uniprot/P23561", - "http://identifiers.org/uniprot/P32917" - complexF part "http://identifiers.org/uniprot/P18851", - "http://identifiers.org/uniprot/P18852", - "http://identifiers.org/uniprot/P08539", - "http://identifiers.org/uniprot/P16892", - "http://identifiers.org/uniprot/Q03497", - "http://identifiers.org/uniprot/P06784", - "http://identifiers.org/uniprot/P32917", - "http://identifiers.org/uniprot/P23561" - complexG part "http://identifiers.org/uniprot/P18852", - "http://identifiers.org/uniprot/P18851", - "http://identifiers.org/uniprot/P08539", - "http://identifiers.org/uniprot/P16892", - "http://identifiers.org/uniprot/P06784", - "http://identifiers.org/uniprot/P23561", - "http://identifiers.org/uniprot/Q03497", - "http://identifiers.org/uniprot/P32917" - complexH part "http://identifiers.org/uniprot/P18852", - "http://identifiers.org/uniprot/P18851", - "http://identifiers.org/uniprot/P16892", - "http://identifiers.org/uniprot/P08539", - "http://identifiers.org/uniprot/P06784", - "http://identifiers.org/uniprot/P23561", - "http://identifiers.org/uniprot/Q03497", - "http://identifiers.org/uniprot/P32917" - complexI part "http://identifiers.org/uniprot/P18852", - "http://identifiers.org/uniprot/P18851", - "http://identifiers.org/uniprot/P08539", - "http://identifiers.org/uniprot/P06784", - "http://identifiers.org/uniprot/P16892", - "http://identifiers.org/uniprot/Q03497", - "http://identifiers.org/uniprot/P23561", - "http://identifiers.org/uniprot/P32917" - complexL part "http://identifiers.org/uniprot/P18852", - "http://identifiers.org/uniprot/P18851", - "http://identifiers.org/uniprot/P08539", - "http://identifiers.org/uniprot/P06784", - "http://identifiers.org/uniprot/Q03497", - "http://identifiers.org/uniprot/P23561", - "http://identifiers.org/uniprot/P32917" - Fus3PP identity "http://identifiers.org/uniprot/P16892" - complexK part "http://identifiers.org/uniprot/P18852", - "http://identifiers.org/uniprot/P18851", - "http://identifiers.org/uniprot/P08539", - "http://identifiers.org/uniprot/P16892", - "http://identifiers.org/uniprot/P06784", - "http://identifiers.org/uniprot/Q03497", - "http://identifiers.org/uniprot/P23561", - "http://identifiers.org/uniprot/P32917" - Ste12 identity "http://identifiers.org/uniprot/P13574" - Ste12a identity "http://identifiers.org/uniprot/P13574" - Bar1 identity "http://identifiers.org/uniprot/P12630" - Bar1a identity "http://identifiers.org/uniprot/P12630" - Bar1aex identity "http://identifiers.org/uniprot/P12630" - Far1 identity "http://identifiers.org/uniprot/P21268" - Far1PP identity "http://identifiers.org/uniprot/P21268" - Far1U identity "http://identifiers.org/uniprot/P21268" - complexM part "http://identifiers.org/uniprot/P21268", - "http://identifiers.org/uniprot/P18851", - "http://identifiers.org/uniprot/P18852" - complexN part "http://identifiers.org/uniprot/P21268", - "http://identifiers.org/uniprot/P00546" - Cdc28 identity "http://identifiers.org/uniprot/P00546" - Sst2 identity "http://identifiers.org/uniprot/P11972" - v1 hypernym "http://identifiers.org/go/GO:0030163" - v2 identity "http://identifiers.org/intact/EBI-904275" - v2 hypernym "http://identifiers.org/go/GO:0004934" - v3 identity "http://identifiers.org/intact/EBI-904275" - v4 hypernym "http://identifiers.org/go/GO:0030163" - v5 hypernym "http://identifiers.org/go/GO:0030163" - v6 version "http://identifiers.org/intact/EBI-380703", - "http://identifiers.org/intact/EBI-48387", - "http://identifiers.org/intact/EBI-877237" - v6 hypernym "http://identifiers.org/go/GO:0004930" - v7 hypernym "http://identifiers.org/go/GO:0003924" - v8 hypernym "http://identifiers.org/go/GO:0005096" - v8 identity "http://identifiers.org/intact/EBI-904406" - v9 version "http://identifiers.org/intact/EBI-877243", - "http://identifiers.org/intact/EBI-380703" - v10 hypernym "http://identifiers.org/go/GO:0005078" - v10 identity "http://identifiers.org/intact/EBI-903953" - v11 hypernym "http://identifiers.org/go/GO:0043241" - v12 identity "http://identifiers.org/intact/EBI-877414" - v13 hypernym "http://identifiers.org/go/GO:0043241" - v14 hypernym "http://identifiers.org/go/GO:0051019" - v14 identity "http://identifiers.org/intact/EBI-877260" - v15 hypernym "http://identifiers.org/go/GO:0043241" - v16 hypernym "http://identifiers.org/go/GO:0005078" - v16 part "http://identifiers.org/intact/EBI-895753", - "http://identifiers.org/intact/EBI-877421", - "http://identifiers.org/intact/EBI-877417" - v17 hypernym "http://identifiers.org/go/GO:0043241" - v18 hypernym "http://identifiers.org/go/GO:0004674" - v18 identity "http://identifiers.org/intact/EBI-903992" - v19 hypernym "http://identifiers.org/go/GO:0043241" - v20 hypernym "http://identifiers.org/ec-code/2.7.11.1", - "http://identifiers.org/go/GO:0000185", - "http://identifiers.org/go/GO:0008349" - v21 hypernym "http://identifiers.org/go/GO:0043241" - v22 hypernym "http://identifiers.org/ec-code/2.7.11.25", - "http://identifiers.org/go/GO:0000186", - "http://identifiers.org/go/GO:0004709" - v23 hypernym "http://identifiers.org/go/GO:0043241" - v24 hypernym "http://identifiers.org/ec-code/2.7.12.2", - "http://identifiers.org/go/GO:0004708", - "http://identifiers.org/go/GO:0000187" - v25 hypernym "http://identifiers.org/go/GO:0043241" - v26 hypernym "http://identifiers.org/go/GO:0006468" - v27 hypernym "http://identifiers.org/go/GO:0043241" - v28 hypernym "http://identifiers.org/go/GO:0043241" - v29 hypernym "http://identifiers.org/go/GO:0051019" - v29 part "http://identifiers.org/intact/EBI-877260", - "http://identifiers.org/intact/EBI-877421" - v30 hypernym "http://identifiers.org/go/GO:0043241" - v31 hypernym "http://identifiers.org/ec-code/2.7.12.2", - "http://identifiers.org/go/GO:0004708", - "http://identifiers.org/go/GO:0000187" - v32 hypernym "http://identifiers.org/go/GO:0043241" - v33 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0016311", - "http://identifiers.org/go/GO:0000188" - v34 hypernym "http://identifiers.org/go/GO:0004707", - "http://identifiers.org/go/GO:0051019" - v35 hypernym "http://identifiers.org/go/GO:0043241" - v36 hypernym "http://identifiers.org/go/GO:0003700" - v37 hypernym "http://identifiers.org/go/GO:0043241" - v38 hypernym "http://identifiers.org/go/GO:0006611" - v39 hypernym "http://identifiers.org/ec-code/2.7.11.24", - "http://identifiers.org/go/GO:0004707" - v40 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0016311" - v41 hypernym "http://identifiers.org/go/GO:0016567" - v43 hypernym "http://identifiers.org/go/GO:0043241" - v44 hypernym "http://identifiers.org/go/GO:0043241" - v45 hypernym "http://identifiers.org/go/GO:0004861" - v46 hypernym "http://identifiers.org/ec-code/2.7.11.24", - "http://identifiers.org/go/GO:0004707" -end - -Kofahl2004_PheromonePathway is "Kofahl2004_PheromonePathway" - -Kofahl2004_PheromonePathway model_entity_is "http://identifiers.org/biomodels.db/MODEL6618819961" -Kofahl2004_PheromonePathway model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000032" -Kofahl2004_PheromonePathway description "http://identifiers.org/pubmed/15300679" -Kofahl2004_PheromonePathway hypernym "http://identifiers.org/go/GO:0019236" -Kofahl2004_PheromonePathway taxon "http://identifiers.org/taxonomy/4932" -Kofahl2004_PheromonePathway part "http://identifiers.org/go/GO:0000165" diff --git a/BioModelsRAG/data/BIOMD0000000033.txt b/BioModelsRAG/data/BIOMD0000000033.txt deleted file mode 100644 index dc54ef5491023c0f1e64497854ed9bfc37537cf9..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000033.txt +++ /dev/null @@ -1,278 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Brown2004_NGF_EGF_signaling() - - // Compartments and Species: - compartment cell; - species EGF in cell, NGF in cell, freeEGFReceptor in cell, boundEGFReceptor in cell; - species freeNGFReceptor in cell, boundNGFReceptor in cell, SosInactive in cell; - species SosActive in cell, P90RskInactive in cell, P90RskActive in cell; - species RasInactive in cell, RasActive in cell, $RasGapActive in cell, Raf1Inactive in cell; - species Raf1Active in cell, BRafInactive in cell, BRafActive in cell, MekInactive in cell; - species MekActive in cell, ErkInactive in cell, ErkActive in cell, PI3KInactive in cell; - species PI3KActive in cell, AktInactive in cell, AktActive in cell, C3GInactive in cell; - species C3GActive in cell, Rap1Inactive in cell, Rap1Active in cell, $RapGapActive in cell; - species $PP2AActive in cell, $Raf1PPtase in cell; - - // Reactions: - EGFBindingReaction: EGF + freeEGFReceptor => boundEGFReceptor; cell*krbEGF*EGF*freeEGFReceptor; - EGFUnbindingReaction: boundEGFReceptor => EGF + freeEGFReceptor; cell*kruEGF*boundEGFReceptor; - NGFBindingReaction: NGF + freeNGFReceptor => boundNGFReceptor; krbNGF*NGF*freeNGFReceptor*cell; - NGFUnbindingReaction: boundNGFReceptor => NGF + freeNGFReceptor; kruNGF*boundNGFReceptor*cell; - SosActivationByEGFReaction: SosInactive -> SosActive; cell*(kEGF*boundEGFReceptor*SosInactive/(SosInactive + KmEGF)); - SosActivationByNGFReaction: SosInactive -> SosActive; cell*(kNGF*boundNGFReceptor*SosInactive/(SosInactive + KmNGF)); - SosDeactivationReaction: SosActive -> SosInactive; cell*(kdSos*P90RskActive*SosActive/(SosActive + KmdSos)); - RasActivationReaction: RasInactive -> RasActive; cell*(kSos*SosActive*RasInactive/(RasInactive + KmSos)); - RasDeactivationReaction: RasActive -> RasInactive; cell*(kRasGap*RasGapActive*RasActive/(RasActive + KmRasGap)); - Raf1ByRasActivationReaction: Raf1Inactive -> Raf1Active; cell*(kRasToRaf1*RasActive*Raf1Inactive/(Raf1Inactive + KmRasToRaf1)); - MekbyRaf1ActivationReaction: MekInactive -> MekActive; cell*(kpRaf1*Raf1Active*MekInactive/(MekInactive + KmpRaf1)); - MekbyBRafActivationReaction: MekInactive -> MekActive; cell*(kpBRaf*BRafActive*MekInactive/(MekInactive + KmpBRaf)); - ErkActivationReaction: ErkInactive -> ErkActive; cell*(kpMekCytoplasmic*MekActive*ErkInactive/(ErkInactive + KmpMekCytoplasmic)); - MekDeactivationReaction: MekActive -> MekInactive; cell*(kdMek*PP2AActive*MekActive/(MekActive + KmdMek)); - ErkDeactivationReaction: ErkActive -> ErkInactive; cell*(kdErk*PP2AActive*ErkActive/(ErkActive + KmdErk)); - Raf1byPPtaseDeactivationReaction: Raf1Active -> Raf1Inactive; cell*(kdRaf1*Raf1PPtase*Raf1Active/(Raf1Active + KmdRaf1)); - P90RskActivationReaction: P90RskInactive -> P90RskActive; cell*(kpP90Rsk*ErkActive*P90RskInactive/(P90RskInactive + KmpP90Rsk)); - PI3KbyEGFRActivationReaction: PI3KInactive -> PI3KActive; cell*(kPI3K*boundEGFReceptor*PI3KInactive/(PI3KInactive + KmPI3K)); - PI3KbyRasActivationReaction: PI3KInactive -> PI3KActive; cell*(kPI3KRas*RasActive*PI3KInactive/(PI3KInactive + KmPI3KRas)); - AktActivationReaction: AktInactive -> AktActive; cell*(kAkt*PI3KActive*AktInactive/(AktInactive + KmAkt)); - Raf1ByAktDeactivationReaction: Raf1Active -> Raf1Inactive; cell*(kdRaf1ByAkt*AktActive*Raf1Active/(Raf1Active + KmRaf1ByAkt)); - C3GActivationReaction: C3GInactive -> C3GActive; cell*(kC3GNGF*boundNGFReceptor*C3GInactive/(C3GInactive + KmC3GNGF)); - Rap1ActivationReaction: Rap1Inactive -> Rap1Active; cell*(kC3G*C3GActive*Rap1Inactive/(Rap1Inactive + KmC3G)); - Rap1DeactivationReaction: Rap1Active -> Rap1Inactive; cell*(kRapGap*RapGapActive*Rap1Active/(Rap1Active + KmRapGap)); - BRafByRap1ActivationReaction: BRafInactive -> BRafActive; cell*(kRap1ToBRaf*Rap1Active*BRafInactive/(BRafInactive + KmRap1ToBRaf)); - BRafbyPPtaseDeactivationReaction: BRafActive -> BRafInactive; cell*(kdBRaf*Raf1PPtase*BRafActive/(BRafActive + KmdBRaf)); - - // Species initializations: - EGF = 10002000; - NGF = 456000; - freeEGFReceptor = 80000; - boundEGFReceptor = 0; - freeNGFReceptor = 10000; - boundNGFReceptor = 0; - SosInactive = 120000; - SosActive = 0; - P90RskInactive = 120000; - P90RskActive = 0; - RasInactive = 120000; - RasActive = 0; - RasGapActive = 120000; - Raf1Inactive = 120000; - Raf1Active = 0; - BRafInactive = 120000; - BRafActive = 0; - MekInactive = 600000; - MekActive = 0; - ErkInactive = 600000; - ErkActive = 0; - PI3KInactive = 120000; - PI3KActive = 0; - AktInactive = 120000; - AktActive = 0; - C3GInactive = 120000; - C3GActive = 0; - Rap1Inactive = 120000; - Rap1Active = 0; - RapGapActive = 120000; - PP2AActive = 120000; - Raf1PPtase = 120000; - - // Compartment initializations: - cell = 1; - - // Variable initializations: - krbEGF = 2.18503e-05; - kruEGF = 0.0121008; - krbNGF = 1.38209e-07; - kruNGF = 0.00723811; - kEGF = 694.731; - KmEGF = 6086070; - kNGF = 389.428; - KmNGF = 2112.66; - kdSos = 1611.97; - KmdSos = 896896; - kSos = 32.344; - KmSos = 35954.3; - kRasGap = 1509.36; - KmRasGap = 1432410; - kRasToRaf1 = 0.884096; - KmRasToRaf1 = 62464.6; - kpRaf1 = 185.759; - KmpRaf1 = 4768350; - kpBRaf = 125.089; - KmpBRaf = 157948; - kdMek = 2.83243; - KmdMek = 518753; - kpMekCytoplasmic = 9.85367; - KmpMekCytoplasmic = 1007340; - kdErk = 8.8912; - KmdErk = 3496490; - kpP90Rsk = 0.0213697; - KmpP90Rsk = 763523; - kPI3K = 10.6737; - KmPI3K = 184912; - kPI3KRas = 0.0771067; - KmPI3KRas = 272056; - kAkt = 0.0566279; - KmAkt = 653951; - kdRaf1ByAkt = 15.1212; - KmRaf1ByAkt = 119355; - kC3GNGF = 146.912; - KmC3GNGF = 12876.2; - kC3G = 1.40145; - KmC3G = 10965.6; - kRapGap = 27.265; - KmRapGap = 295990; - kRap1ToBRaf = 2.20995; - KmRap1ToBRaf = 1025460; - kdRaf1 = 0.126329; - KmdRaf1 = 1061.71; - kdBRaf = 441.287; - KmdBRaf = 10879500; - - // Other declarations: - const cell, krbEGF, kruEGF, krbNGF, kruNGF, kEGF, KmEGF, kNGF, KmNGF, kdSos; - const KmdSos, kSos, KmSos, kRasGap, KmRasGap, kRasToRaf1, KmRasToRaf1, kpRaf1; - const KmpRaf1, kpBRaf, KmpBRaf, kdMek, KmdMek, kpMekCytoplasmic, KmpMekCytoplasmic; - const kdErk, KmdErk, kpP90Rsk, KmpP90Rsk, kPI3K, KmPI3K, kPI3KRas, KmPI3KRas; - const kAkt, KmAkt, kdRaf1ByAkt, KmRaf1ByAkt, kC3GNGF, KmC3GNGF, kC3G, KmC3G; - const kRapGap, KmRapGap, kRap1ToBRaf, KmRap1ToBRaf, kdRaf1, KmdRaf1, kdBRaf; - const KmdBRaf; - - // Unit definitions: - unit substance = item; - unit time_unit = 60 second; - - // Display Names: - substance is "item (default)"; - time_unit is "minute (default)"; - EGFBindingReaction is "EGF binding"; - EGFUnbindingReaction is "EFG unbinding"; - NGFBindingReaction is "NGF binding"; - NGFUnbindingReaction is "NGF unbinding"; - SosActivationByEGFReaction is "SOS activation by EGF"; - SosActivationByNGFReaction is "SOS activation by NGF"; - SosDeactivationReaction is "SOS deactivation"; - RasActivationReaction is "Ras activation"; - RasDeactivationReaction is "Ras deactivation"; - Raf1ByRasActivationReaction is "Raf1 activation by Ras"; - MekbyRaf1ActivationReaction is "Mek activation by Raf1"; - MekbyBRafActivationReaction is "Mek activation by B-Raf"; - ErkActivationReaction is "Erk activation"; - MekDeactivationReaction is "Mek deactivation"; - ErkDeactivationReaction is "Erk deactivation"; - Raf1byPPtaseDeactivationReaction is "Raf1 deactivation by PPase"; - P90RskActivationReaction is "P90Rsk activation"; - PI3KbyEGFRActivationReaction is "PI3K activation by EGFR"; - PI3KbyRasActivationReaction is "PI3K activation by Ras"; - AktActivationReaction is "Akt activation"; - Raf1ByAktDeactivationReaction is "Raf1 deactivation by Akt"; - C3GActivationReaction is "C3G activation"; - Rap1ActivationReaction is "Rap1 activation"; - Rap1DeactivationReaction is "Rap1 deactivation"; - BRafByRap1ActivationReaction is "BRaf activation by Rap1"; - BRafbyPPtaseDeactivationReaction is "BRaf deactivation by PPase"; - - // CV terms: - cell identity "http://identifiers.org/go/GO:0005623" - EGF identity "http://identifiers.org/uniprot/P07522" - NGF identity "http://identifiers.org/uniprot/P25427" - freeEGFReceptor identity "http://identifiers.org/uniprot/Q9QX70" - boundEGFReceptor part "http://identifiers.org/uniprot/Q9QX70", - "http://identifiers.org/uniprot/P07522" - freeNGFReceptor identity "http://identifiers.org/uniprot/P35739" - boundNGFReceptor part "http://identifiers.org/uniprot/P35739", - "http://identifiers.org/uniprot/P25427" - SosInactive hypernym "http://identifiers.org/ensembl/ENSRNOP00000009359", - "http://identifiers.org/uniprot/Q9Z1I1" - SosActive hypernym "http://identifiers.org/ensembl/ENSRNOP00000009359", - "http://identifiers.org/uniprot/Q9Z1I1" - P90RskInactive version "http://identifiers.org/uniprot/Q9Z1I2", - "http://identifiers.org/uniprot/Q63531" - P90RskActive version "http://identifiers.org/uniprot/Q9Z1I2", - "http://identifiers.org/uniprot/Q63531" - RasInactive hypernym "http://identifiers.org/interpro/IPR003577" - RasActive hypernym "http://identifiers.org/interpro/IPR003577" - RasGapActive identity "http://identifiers.org/uniprot/P50904" - Raf1Inactive hypernym "http://identifiers.org/uniprot/P11345" - Raf1Active hypernym "http://identifiers.org/uniprot/P11345" - BRafInactive hypernym "http://identifiers.org/uniprot/Q99MC6" - BRafActive hypernym "http://identifiers.org/uniprot/Q99MC6" - MekInactive hypernym "http://identifiers.org/uniprot/Q01986", - "http://identifiers.org/uniprot/P36506" - MekActive hypernym "http://identifiers.org/uniprot/Q01986", - "http://identifiers.org/uniprot/P36506" - ErkInactive hypernym "http://identifiers.org/uniprot/P21708", - "http://identifiers.org/uniprot/P63086" - ErkActive hypernym "http://identifiers.org/uniprot/P21708", - "http://identifiers.org/uniprot/P63086" - PI3KInactive part "http://identifiers.org/interpro/IPR015433" - PI3KInactive hypernym "http://identifiers.org/go/GO:0005942" - PI3KActive part "http://identifiers.org/interpro/IPR015433" - PI3KActive hypernym "http://identifiers.org/go/GO:0005942" - AktInactive version "http://identifiers.org/uniprot/P47196", - "http://identifiers.org/uniprot/P47197", - "http://identifiers.org/uniprot/Q63484" - AktActive version "http://identifiers.org/uniprot/P47196", - "http://identifiers.org/uniprot/P47197", - "http://identifiers.org/uniprot/Q63484" - C3GInactive hypernym "http://identifiers.org/uniprot/Q9QYV3" - C3GActive hypernym "http://identifiers.org/uniprot/Q9QYV3" - Rap1Inactive version "http://identifiers.org/uniprot/P10113", - "http://identifiers.org/uniprot/Q62636" - Rap1Active version "http://identifiers.org/uniprot/P10113", - "http://identifiers.org/uniprot/Q62636" - RapGapActive identity "http://identifiers.org/uniprot/P47736" - PP2AActive identity "http://identifiers.org/go/GO:0000159" - EGFBindingReaction identity "http://identifiers.org/go/GO:0048408" - EGFBindingReaction hypernym "http://identifiers.org/go/GO:0045741" - EGFUnbindingReaction hypernym "http://identifiers.org/go/GO:0007175" - NGFBindingReaction hypernym "http://identifiers.org/go/GO:0051396" - NGFBindingReaction identity "http://identifiers.org/go/GO:0048406" - NGFUnbindingReaction hypernym "http://identifiers.org/go/GO:0051395" - SosActivationByEGFReaction hypernym "http://identifiers.org/ec-code/2.7.1.37", - "http://identifiers.org/go/GO:0004716" - SosActivationByNGFReaction hypernym "http://identifiers.org/ec-code/2.7.1.37", - "http://identifiers.org/go/GO:0004716" - SosDeactivationReaction hypernym "http://identifiers.org/ec-code/2.7.1.37" - RasActivationReaction identity "http://identifiers.org/go/GO:0046579" - RasDeactivationReaction identity "http://identifiers.org/go/GO:0046580" - Raf1ByRasActivationReaction hypernym "http://identifiers.org/ec-code/2.7.1.37", - "http://identifiers.org/go/GO:0008349", - "http://identifiers.org/go/GO:0000185" - MekbyRaf1ActivationReaction hypernym "http://identifiers.org/ec-code/2.7.1.37", - "http://identifiers.org/go/GO:0004709", - "http://identifiers.org/go/GO:0000186" - MekbyBRafActivationReaction hypernym "http://identifiers.org/ec-code/2.7.1.37", - "http://identifiers.org/go/GO:0004709", - "http://identifiers.org/go/GO:0000186" - ErkActivationReaction hypernym "http://identifiers.org/ec-code/2.7.1.37", - "http://identifiers.org/go/GO:0000187", - "http://identifiers.org/go/GO:0004708" - MekDeactivationReaction hypernym "http://identifiers.org/ec-code/3.1.3.16" - ErkDeactivationReaction hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0000188" - Raf1byPPtaseDeactivationReaction hypernym "http://identifiers.org/ec-code/3.1.3.16" - P90RskActivationReaction hypernym "http://identifiers.org/ec-code/2.7.1.37", - "http://identifiers.org/go/GO:0004707" - PI3KbyEGFRActivationReaction hypernym "http://identifiers.org/ec-code/2.7.1.37" - PI3KbyRasActivationReaction hypernym "http://identifiers.org/ec-code/2.7.1.37", - "http://identifiers.org/go/GO:0008349" - AktActivationReaction hypernym "http://identifiers.org/go/GO:0045860" - Raf1ByAktDeactivationReaction hypernym "http://identifiers.org/ec-code/2.7.1.37" - C3GActivationReaction hypernym "http://identifiers.org/ec-code/2.7.1.37", - "http://identifiers.org/go/GO:0004716" - Rap1ActivationReaction identity "http://identifiers.org/go/GO:0046582" - BRafByRap1ActivationReaction hypernym "http://identifiers.org/ec-code/2.7.1.37", - "http://identifiers.org/go/GO:0000185" - BRafbyPPtaseDeactivationReaction hypernym "http://identifiers.org/ec-code/3.1.3.16" -end - -Brown2004_NGF_EGF_signaling is "Brown2004 - NGF and EGF signaling" - -Brown2004_NGF_EGF_signaling model_entity_is "http://identifiers.org/biomodels.db/MODEL6619514794" -Brown2004_NGF_EGF_signaling model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000033" -Brown2004_NGF_EGF_signaling description "http://identifiers.org/pubmed/16204838" -Brown2004_NGF_EGF_signaling hypernym "http://identifiers.org/go/GO:0070371" -Brown2004_NGF_EGF_signaling taxon "http://identifiers.org/taxonomy/131567" -Brown2004_NGF_EGF_signaling property "http://identifiers.org/mamo/MAMO_0000046" -Brown2004_NGF_EGF_signaling part "http://identifiers.org/go/GO:0048011", - "http://identifiers.org/go/GO:0007173" diff --git a/BioModelsRAG/data/BIOMD0000000034.txt b/BioModelsRAG/data/BIOMD0000000034.txt deleted file mode 100644 index 820d14a610278a1c8d740cff3a3c46ed791a1bf8..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000034.txt +++ /dev/null @@ -1,259 +0,0 @@ -// Created by libAntimony v2.13.0 -model *model_0000001() - - // Compartments and Species: - compartment compartment_0000002, compartment_0000001; - species species_0000001 in compartment_0000001, species_0000002 in compartment_0000001; - species species_0000003 in compartment_0000001, species_0000004 in compartment_0000002; - species species_0000005 in compartment_0000002, species_0000006 in compartment_0000002; - species species_0000007 in compartment_0000001, species_0000008 in compartment_0000001; - species species_0000009 in compartment_0000001; - - // Rate Rules: - parameter_0000001' = parameter_0000017*(species_0000008/(species_0000008 + parameter_0000011))*(parameter_0000005/(parameter_0000005 + species_0000001 + species_0000002 + species_0000003))*(1 - parameter_0000001) - parameter_0000014*parameter_0000001; - parameter_0000002' = parameter_0000018*(species_0000008/(species_0000008 + parameter_0000012))*(parameter_0000006/(parameter_0000006 + species_0000001 + species_0000002 + species_0000003))*(1 - parameter_0000002) - parameter_0000015*parameter_0000002; - parameter_0000003' = parameter_0000019*(species_0000008/(species_0000008 + parameter_0000013))*(parameter_0000007/(parameter_0000007 + species_0000001 + species_0000002 + species_0000003))*(1 - parameter_0000003) - parameter_0000016*parameter_0000003; - parameter_0000020' = (parameter_0000001^parameter_0000026 - parameter_0000020)/parameter_0000023; - parameter_0000021' = (parameter_0000002^parameter_0000026 - parameter_0000021)/parameter_0000024; - parameter_0000022' = (parameter_0000003^parameter_0000026 - parameter_0000022)/parameter_0000025; - - // Reactions: - reaction_0000001: => species_0000004; compartment_0000002*(parameter_0000027*parameter_0000021 + parameter_0000031); - reaction_0000002: => species_0000007; compartment_0000001*(parameter_0000028*parameter_0000020 + parameter_0000032); - reaction_0000003: => species_0000009; compartment_0000001*delay(parameter_0000029*parameter_0000022 + parameter_0000034, parameter_0000039); - reaction_0000004: => species_0000008; compartment_0000001*(parameter_0000030*(species_0000009^2/(species_0000009^2 + parameter_0000010^2))*(parameter_0000008^2/(species_0000007^2 + parameter_0000008^2)) + parameter_0000033); - reaction_0000005: species_0000008 => ; compartment_0000001*parameter_0000036*species_0000008; - reaction_0000006: species_0000009 => ; compartment_0000001*parameter_0000038*species_0000009; - reaction_0000007: species_0000007 => ; compartment_0000001*parameter_0000037*species_0000007; - reaction_0000008: species_0000004 => species_0000005; compartment_0000002*(parameter_0000040*species_0000004/(parameter_0000041 + species_0000004)); - reaction_0000009: species_0000005 => species_0000006; compartment_0000002*(parameter_0000040*species_0000005/(parameter_0000041 + species_0000005)); - reaction_0000010: species_0000006 => species_0000001; compartment_0000002*(parameter_0000044*species_0000006/(parameter_0000045 + species_0000006)); - reaction_0000011: species_0000001 => species_0000002; compartment_0000001*(parameter_0000042*species_0000001/(parameter_0000043 + species_0000001)); - reaction_0000012: species_0000002 => species_0000003; compartment_0000001*(parameter_0000042*species_0000002/(parameter_0000043 + species_0000002)); - reaction_0000013: species_0000003 => ; compartment_0000001*(parameter_0000046*species_0000003/(parameter_0000047 + species_0000003)); - reaction_0000014: species_0000008 => ; compartment_0000001*parameter_0000048*species_0000008; - reaction_0000015: species_0000009 => ; compartment_0000001*parameter_0000048*species_0000009; - reaction_0000016: species_0000007 => ; compartment_0000001*parameter_0000048*species_0000007; - reaction_0000017: species_0000004 => ; compartment_0000002*parameter_0000048*species_0000004; - reaction_0000018: species_0000005 => ; compartment_0000002*parameter_0000048*species_0000005; - reaction_0000019: species_0000006 => ; compartment_0000002*parameter_0000048*species_0000006; - reaction_0000020: species_0000001 => ; compartment_0000001*parameter_0000048*species_0000001; - reaction_0000021: species_0000002 => ; compartment_0000001*parameter_0000048*species_0000002; - reaction_0000022: species_0000003 => ; compartment_0000001*parameter_0000048*species_0000003; - - // Species initializations: - species_0000001 = 0.001; - species_0000002 = 0.001; - species_0000003 = 0.001; - species_0000004 = 0.001; - species_0000005 = 0.001; - species_0000006 = 0.001; - species_0000007 = 0.001; - species_0000008 = 0.001; - species_0000009 = 0.001; - - // Compartment initializations: - compartment_0000002 = 1; - compartment_0000001 = 1; - - // Variable initializations: - parameter_0000001 = ; - parameter_0000017 = 1.062; - parameter_0000011 = 0.083; - parameter_0000005 = 0.2; - parameter_0000014 = 0.2124; - parameter_0000002 = ; - parameter_0000018 = 1.062; - parameter_0000012 = 0.134; - parameter_0000006 = 0.24; - parameter_0000015 = 0.2124; - parameter_0000003 = ; - parameter_0000019 = 1.062; - parameter_0000013 = 0.248; - parameter_0000007 = 0.1; - parameter_0000016 = 0.2124; - parameter_0000008 = 0.54; - parameter_0000010 = 0.54; - parameter_0000020 = ; - parameter_0000026 = 5; - parameter_0000023 = 2.8249; - parameter_0000021 = ; - parameter_0000024 = 2.8249; - parameter_0000022 = ; - parameter_0000025 = 2.8249; - parameter_0000027 = 10.62; - parameter_0000028 = 76.464; - parameter_0000029 = 344.09; - parameter_0000030 = 1.062; - parameter_0000031 = 0.02124; - parameter_0000032 = 0.19116; - parameter_0000033 = 0.001062; - parameter_0000034 = 0.38232; - parameter_0000036 = 0.2124; - parameter_0000037 = 0.7434; - parameter_0000038 = 0.6903; - parameter_0000039 = 2.8249; - parameter_0000040 = 1.6992; - parameter_0000041 = 0.25; - parameter_0000042 = 0.3186; - parameter_0000043 = 0.001; - parameter_0000044 = 1.6992; - parameter_0000045 = 0.25; - parameter_0000046 = 5.31; - parameter_0000047 = 0.01; - parameter_0000048 = 0.00531; - - // Other declarations: - var parameter_0000001, parameter_0000002, parameter_0000003, parameter_0000020; - var parameter_0000021, parameter_0000022; - const compartment_0000002, compartment_0000001, parameter_0000017, parameter_0000011; - const parameter_0000005, parameter_0000014, parameter_0000018, parameter_0000012; - const parameter_0000006, parameter_0000015, parameter_0000019, parameter_0000013; - const parameter_0000007, parameter_0000016, parameter_0000008, parameter_0000010; - const parameter_0000026, parameter_0000023, parameter_0000024, parameter_0000025; - const parameter_0000027, parameter_0000028, parameter_0000029, parameter_0000030; - const parameter_0000031, parameter_0000032, parameter_0000033, parameter_0000034; - const parameter_0000036, parameter_0000037, parameter_0000038, parameter_0000039; - const parameter_0000040, parameter_0000041, parameter_0000042, parameter_0000043; - const parameter_0000044, parameter_0000045, parameter_0000046, parameter_0000047; - const parameter_0000048; - - // Unit definitions: - unit time_unit = 3600 second; - unit substance = 1e-9 mole; - - // Display Names: - time_unit is "hour"; - substance is "nanomole"; - compartment_0000002 is "cytoplasm"; - compartment_0000001 is "nucleus"; - species_0000001 is "P0nuc"; - species_0000002 is "P1nuc"; - species_0000003 is "P2nuc"; - species_0000004 is "P0cyt"; - species_0000005 is "P1cyt"; - species_0000006 is "P2cyt"; - species_0000007 is "VRI"; - species_0000008 is "CLK"; - species_0000009 is "PDP"; - parameter_0000001 is "ACvri"; - parameter_0000017 is "Fv"; - parameter_0000011 is "Kcv"; - parameter_0000005 is "Kpv"; - parameter_0000014 is "Kvdeac"; - parameter_0000002 is "ACper"; - parameter_0000018 is "Fp"; - parameter_0000012 is "Kcp"; - parameter_0000006 is "Kpp"; - parameter_0000015 is "Kpdeac"; - parameter_0000003 is "ACpdp"; - parameter_0000019 is "Fpd"; - parameter_0000013 is "Kcpd"; - parameter_0000007 is "Kppd"; - parameter_0000016 is "Kpddeac"; - parameter_0000008 is "Kvc"; - parameter_0000010 is "Kpdc"; - parameter_0000020 is "OPvri"; - parameter_0000026 is "N"; - parameter_0000023 is "Tvriop"; - parameter_0000021 is "OPper"; - parameter_0000024 is "Tperop"; - parameter_0000022 is "OPpdp"; - parameter_0000025 is "Tpdpop"; - parameter_0000027 is "Vper"; - parameter_0000028 is "Vvri"; - parameter_0000029 is "Vpdp"; - parameter_0000030 is "Vclk"; - parameter_0000031 is "Rpbas"; - parameter_0000032 is "Rvbas"; - parameter_0000033 is "Rcbas"; - parameter_0000034 is "Rpdbas"; - parameter_0000036 is "Vdclk"; - parameter_0000037 is "vdvri"; - parameter_0000038 is "vdpdp"; - parameter_0000039 is "Tdelay"; - parameter_0000040 is "Vpcyt"; - parameter_0000041 is "Kpcyt"; - parameter_0000042 is "Vpnuc"; - parameter_0000043 is "Kpnuc"; - parameter_0000044 is "Vtrans"; - parameter_0000045 is "Ktrans"; - parameter_0000046 is "Vdegp"; - parameter_0000047 is "Kdegp"; - parameter_0000048 is "kd"; - reaction_0000001 is "Per production"; - reaction_0000002 is "Vri production"; - reaction_0000003 is "Pdp production"; - reaction_0000004 is "Clk production"; - reaction_0000005 is "Clk specific degradation"; - reaction_0000006 is "Pdp specific degradation"; - reaction_0000007 is "Vri specific degradation"; - reaction_0000008 is "first cytoplasmic Per phosphorylation"; - reaction_0000009 is "second cytoplasmic Per phosphorylation"; - reaction_0000010 is "Per nuclear transport"; - reaction_0000011 is "first nuclear Per phosphorylation"; - reaction_0000012 is "second nuclear Rer phosphorylation"; - reaction_0000013 is "Per specific degradation"; - reaction_0000014 is "Clk aspecific degradation"; - reaction_0000015 is "Pdp aspecific degradation"; - reaction_0000016 is "Vri aspecific degradation"; - reaction_0000017 is "Per_cyt aspecific degradation"; - reaction_0000018 is "Per-P_cyt aspecific degradation"; - reaction_0000019 is "Per-PP_cyt aspecific degradation"; - reaction_0000020 is "Per_nuc aspecific degradation"; - reaction_0000021 is "Per-P_nuc aspecific degradation"; - reaction_0000022 is "Per-PP_nuc aspecific degradation"; - - // CV terms: - compartment_0000002 identity "http://identifiers.org/go/GO:0005737" - compartment_0000001 identity "http://identifiers.org/go/GO:0005634" - species_0000001 hypernym "http://identifiers.org/uniprot/P07663" - species_0000002 hypernym "http://identifiers.org/uniprot/P07663" - species_0000003 hypernym "http://identifiers.org/uniprot/P07663" - species_0000004 hypernym "http://identifiers.org/uniprot/P07663" - species_0000005 hypernym "http://identifiers.org/uniprot/P07663" - species_0000006 hypernym "http://identifiers.org/uniprot/P07663" - species_0000007 identity "http://identifiers.org/uniprot/O18660" - species_0000008 part "http://identifiers.org/uniprot/O61735", - "http://identifiers.org/uniprot/P07663" - species_0000009 identity "http://identifiers.org/uniprot/Q9TVS7" - reaction_0000001 part "http://identifiers.org/go/GO:0006412", - "http://identifiers.org/go/GO:0006351" - reaction_0000002 part "http://identifiers.org/go/GO:0006412", - "http://identifiers.org/go/GO:0006351" - reaction_0000003 part "http://identifiers.org/go/GO:0006412", - "http://identifiers.org/go/GO:0006351" - reaction_0000004 part "http://identifiers.org/go/GO:0006412", - "http://identifiers.org/go/GO:0006351" - reaction_0000005 hypernym "http://identifiers.org/go/GO:0030163" - reaction_0000006 hypernym "http://identifiers.org/go/GO:0030163" - reaction_0000007 hypernym "http://identifiers.org/go/GO:0030163" - reaction_0000008 hypernym "http://identifiers.org/ec-code/2.7.1.37", - "http://identifiers.org/go/GO:0006468" - reaction_0000009 hypernym "http://identifiers.org/ec-code/2.7.1.37", - "http://identifiers.org/go/GO:0006468" - reaction_0000010 hypernym "http://identifiers.org/go/GO:0006606" - reaction_0000011 hypernym "http://identifiers.org/ec-code/2.7.1.37", - "http://identifiers.org/go/GO:0006468" - reaction_0000012 hypernym "http://identifiers.org/ec-code/2.7.1.37", - "http://identifiers.org/go/GO:0006468" - reaction_0000013 hypernym "http://identifiers.org/go/GO:0030163" - reaction_0000014 hypernym "http://identifiers.org/go/GO:0030163" - reaction_0000015 hypernym "http://identifiers.org/go/GO:0030163" - reaction_0000016 hypernym "http://identifiers.org/go/GO:0030163" - reaction_0000017 hypernym "http://identifiers.org/go/GO:0030163" - reaction_0000018 hypernym "http://identifiers.org/go/GO:0030163" - reaction_0000019 hypernym "http://identifiers.org/go/GO:0030163" - reaction_0000020 hypernym "http://identifiers.org/go/GO:0030163" - reaction_0000021 hypernym "http://identifiers.org/go/GO:0030163" - reaction_0000022 hypernym "http://identifiers.org/go/GO:0030163" -end - -model_0000001 is "Smolen2004_CircClock" - -model_0000001 model_entity_is "http://identifiers.org/biomodels.db/MODEL6619579403" -model_0000001 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000034" -model_0000001 description "http://identifiers.org/pubmed/15111397" -model_0000001 taxon "http://identifiers.org/taxonomy/7227" -model_0000001 identity "http://identifiers.org/kegg.pathway/dme04710" -model_0000001 hypernym "http://identifiers.org/go/GO:0042752" diff --git a/BioModelsRAG/data/BIOMD0000000035.txt b/BioModelsRAG/data/BIOMD0000000035.txt deleted file mode 100644 index edc7981451e91509fa042f155f32e04ecabee62a..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000035.txt +++ /dev/null @@ -1,103 +0,0 @@ -// Created by libAntimony v2.13.0 -model *vilarOscillator() - - // Compartments and Species: - compartment deterministicOscillator; - substanceOnly species $EmptySet in deterministicOscillator, A in deterministicOscillator; - substanceOnly species C in deterministicOscillator, DA in deterministicOscillator; - substanceOnly species DAp in deterministicOscillator, DR in deterministicOscillator; - substanceOnly species DRp in deterministicOscillator, MA in deterministicOscillator; - substanceOnly species MR in deterministicOscillator, R in deterministicOscillator; - - // Reactions: - Reaction1: A + R => C; A*R*Reaction1_gammaC; - Reaction2: A => $EmptySet; A*Reaction2_deltaA; - Reaction3: C => R; C*Reaction3_deltaA; - Reaction4: R => $EmptySet; R*Reaction4_deltaR; - Reaction5: A + DA => DAp; A*DA*Reaction5_gammaA; - Reaction6: DAp => A + DA; DAp*Reaction6_thetaA; - Reaction7: DA => DA + MA; DA*Reaction7_alphaA; - Reaction8: DAp => DAp + MA; DAp*Reaction8_alphaAp; - Reaction9: MA => $EmptySet; MA*Reaction9_deltaMA; - Reaction10: MA => A + MA; MA*Reaction10_betaA; - Reaction11: A + DR => DRp; A*DR*Reaction11_gammaR; - Reaction12: DRp => A + DR; DRp*Reaction12_thetaR; - Reaction13: DR => DR + MR; DR*Reaction13_alphaR; - Reaction14: DRp => DRp + MR; DRp*Reaction14_alphaRp; - Reaction15: MR => $EmptySet; MR*Reaction15_deltaMR; - Reaction16: MR => MR + R; MR*Reaction16_betaR; - - // Species initializations: - EmptySet = 0; - A = 0; - C = 0; - DA = 1/deterministicOscillator; - DAp = 0; - DR = 1/deterministicOscillator; - DRp = 0; - MA = 0; - MR = 0; - R = 0; - - // Compartment initializations: - deterministicOscillator = 1; - - // Variable initializations: - Reaction1_gammaC = 2; - Reaction2_deltaA = 1; - Reaction3_deltaA = 1; - Reaction4_deltaR = 0.2; - Reaction5_gammaA = 1; - Reaction6_thetaA = 50; - Reaction7_alphaA = 50; - Reaction8_alphaAp = 500; - Reaction9_deltaMA = 10; - Reaction10_betaA = 50; - Reaction11_gammaR = 1; - Reaction12_thetaR = 100; - Reaction13_alphaR = 0.01; - Reaction14_alphaRp = 50; - Reaction15_deltaMR = 0.5; - Reaction16_betaR = 5; - - // Other declarations: - const deterministicOscillator; - - // Unit definitions: - unit time_unit = 3600 second; - - // Display Names: - time_unit is "hour"; - - // CV terms: - A hypernym "http://identifiers.org/chebi/CHEBI:36080" - C hypernym "http://identifiers.org/chebi/CHEBI:36080" - MA hypernym "http://identifiers.org/chebi/CHEBI:33699" - MR hypernym "http://identifiers.org/chebi/CHEBI:33699" - R hypernym "http://identifiers.org/chebi/CHEBI:36080" - Reaction1 hypernym "http://identifiers.org/obo.go/GO:0006461" - Reaction2 hypernym "http://identifiers.org/obo.go/GO:0030163" - Reaction3 hypernym "http://identifiers.org/obo.go/GO:0030163" - Reaction4 hypernym "http://identifiers.org/obo.go/GO:0030163" - Reaction5 hypernym "http://identifiers.org/obo.go/GO:0016563" - Reaction6 hypernym "http://identifiers.org/obo.go/GO:0032986" - Reaction7 hypernym "http://identifiers.org/obo.go/GO:0006351" - Reaction8 hypernym "http://identifiers.org/obo.go/GO:0006351" - Reaction9 hypernym "http://identifiers.org/obo.go/GO:0006402" - Reaction10 hypernym "http://identifiers.org/obo.go/GO:0006412" - Reaction11 hypernym "http://identifiers.org/obo.go/GO:0016563", - "http://identifiers.org/obo.go/GO:0010843" - Reaction12 hypernym "http://identifiers.org/obo.go/GO:0032986" - Reaction13 hypernym "http://identifiers.org/obo.go/GO:0006351" - Reaction14 hypernym "http://identifiers.org/obo.go/GO:0006351" - Reaction15 hypernym "http://identifiers.org/obo.go/GO:0006402" - Reaction16 hypernym "http://identifiers.org/obo.go/GO:0006412" -end - -vilarOscillator is "Vilar2002_Oscillator" - -vilarOscillator model_entity_is "http://identifiers.org/biomodels.db/MODEL6619651140" -vilarOscillator model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000035" -vilarOscillator description "http://identifiers.org/pubmed/11972055" -vilarOscillator hypernym "http://identifiers.org/obo.go/GO:0042752" -vilarOscillator taxon "http://identifiers.org/taxonomy/131567" diff --git a/BioModelsRAG/data/BIOMD0000000036.txt b/BioModelsRAG/data/BIOMD0000000036.txt deleted file mode 100644 index 9236435635a85bc2c2da148838c1eb0cb790437c..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000036.txt +++ /dev/null @@ -1,72 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Tyson1999() - - // Compartments and Species: - compartment default, CYTOPLASM; - species $EmptySet in default, M in CYTOPLASM, P in CYTOPLASM; - - // Reactions: - TC: $EmptySet => M; CYTOPLASM*(TC_Vm/(1 + (P*(1 - 2/(1 + (1 + 8*TC_Keq*P)^0.5))/(2*TC_Pcrit))^2)); - TL: $EmptySet => P; TL_V*M*CYTOPLASM; - mRNAD: M => $EmptySet; mRNAD_D*M*CYTOPLASM; - ProteinD: P => $EmptySet; ProteinD_D*P*CYTOPLASM; - DBT: P => $EmptySet; CYTOPLASM*((DBT_k1*P*(2/(1 + (1 + 8*DBT_Keq*P)^0.5)) + DBT_k2*P)/(DBT_J + P)); - - // Species initializations: - EmptySet = 0; - M = 1/CYTOPLASM; - P = 1/CYTOPLASM; - - // Compartment initializations: - default = 1; - CYTOPLASM = 1; - - // Variable initializations: - N_A = 6.0221367e+23; - TC_Vm = 1; - TC_Pcrit = 0.1; - TC_Keq = 200; - TL_V = 0.5; - mRNAD_D = 0.1; - ProteinD_D = 0.1; - DBT_k1 = 10; - DBT_k2 = 0.03; - DBT_J = 0.05; - DBT_Keq = 200; - - // Other declarations: - const default, CYTOPLASM, N_A; - - // Unit definitions: - unit time_unit = 3600 second; - - // Display Names: - time_unit is "hour"; - P is "Pt"; - TC is "transcription"; - TL is "translation"; - mRNAD is "mRNA degradation"; - ProteinD is "protein degradation"; - DBT is "Per phosphorylation and degradation"; - - // CV terms: - CYTOPLASM hypernym "http://identifiers.org/go/GO:0005737" - P identity "http://identifiers.org/uniprot/P07663" - TC hypernym "http://identifiers.org/go/GO:0006355", - "http://identifiers.org/go/GO:0009299" - TL hypernym "http://identifiers.org/go/GO:0006412" - mRNAD hypernym "http://identifiers.org/go/GO:0006402" - ProteinD hypernym "http://identifiers.org/go/GO:0030163" - DBT hypernym "http://identifiers.org/ec-code/2.7.1.37", - "http://identifiers.org/go/GO:0006468", - "http://identifiers.org/go/GO:0030163" -end - -Tyson1999 is "Tyson1999_CircClock" - -Tyson1999 model_entity_is "http://identifiers.org/biomodels.db/MODEL6619720081" -Tyson1999 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000036" -Tyson1999 description "http://identifiers.org/pubmed/20540926" -Tyson1999 identity "http://identifiers.org/kegg.pathway/dme04710" -Tyson1999 taxon "http://identifiers.org/taxonomy/7227" -Tyson1999 hypernym "http://identifiers.org/go/GO:0042752" diff --git a/BioModelsRAG/data/BIOMD0000000037.txt b/BioModelsRAG/data/BIOMD0000000037.txt deleted file mode 100644 index 26a37d840ee424fc6173f9141add713a3888d195..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000037.txt +++ /dev/null @@ -1,89 +0,0 @@ -// Created by libAntimony v2.13.0 -model *BIOMD0000000037() - - // Compartments and Species: - compartment compartment_; - species Pfr in compartment_, Pr in compartment_, Xi in compartment_, Xa in compartment_; - species prepreS in compartment_, preS in compartment_, Ya in compartment_; - species S in compartment_, $Gluc in compartment_, Yi in compartment_, V in compartment_; - species Pi in compartment_; - - // Reactions: - Photoreceptor_activation: Pfr => Pr; compartment_*Pfr*Photoreceptor_activation_IfrSfrPfr; - Photoreceptor_inactivation: Pr => Pfr; Photoreceptor_inactivation_IrSrPr*Pr*compartment_; - Transducer_activation: Xi => Xa; Xi*Transducer_activation_kia*Pr*compartment_; - Transducer_inactivation: Xa => Xi; Transducer_inactivation_kai*Xa*compartment_; - preS_formation: prepreS => preS; prepreS*preS_formation_kx*Xa*compartment_; - S_generation: preS => S; preS*S_generation_ky*Ya*compartment_; - Glucose_sensor_inactivation: Ya + $Gluc => Yi; Glucose_sensor_inactivation_kG*Ya*Gluc*compartment_; - S_formation: => S; compartment_*(S_formation_alpha1/(1 + V^3)); - V_formation: => V; compartment_*(V_formation_alpha2/(1 + S^3)); - S_degradation: S => ; S_degradation_kd_s*S*compartment_; - V_degradation: V => ; compartment_*V*V_degradation_kd_v; - Photoreceptor_decay: Pr => Pi; compartment_*Photoreceptor_decay_kd*Pr; - - // Species initializations: - Pfr = 10/compartment_; - Pr = 0; - Xi = 6/compartment_; - Xa = 0; - prepreS = 200/compartment_; - preS = 0; - Ya = 0.9/compartment_; - S = 0; - Gluc = 0; - Yi = 0; - V = 30/compartment_; - Pi = 0; - - // Compartment initializations: - compartment_ = 1; - - // Variable initializations: - Photoreceptor_activation_IfrSfrPfr = 0.1; - Photoreceptor_inactivation_IrSrPr = 0; - Transducer_activation_kia = 0.1; - Transducer_inactivation_kai = 0.8; - preS_formation_kx = 0.2; - S_generation_ky = 1; - Glucose_sensor_inactivation_kG = 0.1; - S_formation_alpha1 = 30; - V_formation_alpha2 = 50; - S_degradation_kd_s = 1; - V_degradation_kd_v = 1; - Photoreceptor_decay_kd = 0.1; - - // Other declarations: - const compartment_; - - // Unit definitions: - unit time_unit = 3600 second; - - // Display Names: - time_unit is "hour"; - - // CV terms: - Pfr version "http://identifiers.org/chebi/CHEBI:35799", - "http://identifiers.org/interpro/IPR001294" - Pr version "http://identifiers.org/chebi/CHEBI:35799", - "http://identifiers.org/interpro/IPR001294" - Gluc identity "http://identifiers.org/chebi/CHEBI:17234", - "http://identifiers.org/kegg.compound/C00293" - Photoreceptor_activation hypernym "http://identifiers.org/go/GO:0031516" - Photoreceptor_inactivation hypernym "http://identifiers.org/go/GO:0031517" - S_formation hypernym "http://identifiers.org/go/GO:0009299", - "http://identifiers.org/go/GO:0006412" - V_formation hypernym "http://identifiers.org/go/GO:0009299", - "http://identifiers.org/go/GO:0006412" - S_degradation hypernym "http://identifiers.org/go/GO:0006402" - V_degradation hypernym "http://identifiers.org/go/GO:0006402" -end - -BIOMD0000000037 is "Marwan2003 - Genetics, regulatory hierarchy between genes" - -BIOMD0000000037 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000037" -BIOMD0000000037 model_entity_is "http://identifiers.org/biomodels.db/MODEL6621175859" -BIOMD0000000037 description "http://identifiers.org/pubmed/12750324" -BIOMD0000000037 hypernym "http://identifiers.org/go/GO:0010018", - "http://identifiers.org/go/GO:0042173" -BIOMD0000000037 taxon "http://identifiers.org/taxonomy/5791" diff --git a/BioModelsRAG/data/BIOMD0000000038.txt b/BioModelsRAG/data/BIOMD0000000038.txt deleted file mode 100644 index 7d74487ccf6364e016ee1f950a3126fb6fb1850d..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000038.txt +++ /dev/null @@ -1,158 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Rohwer2000_Phosphotransferase_System() - - // Compartments and Species: - compartment compartment_; - species EI in compartment_, PyrPI in compartment_, EIP in compartment_; - species HPr in compartment_, EIPHPr in compartment_, HPrP in compartment_; - species EIIA in compartment_, HPrPIIA in compartment_, EIIAP in compartment_; - species EIICB in compartment_, EIIAPIICB in compartment_, EIICBP in compartment_; - species EIICBPGlc in compartment_, $PEP in compartment_, $Pyr in compartment_; - species $GlcP in compartment_, $Glc in compartment_; - - // Reactions: - v1: $PEP + EI -> PyrPI; compartment_*(v1_k1f*PEP*EI - v1_k1r*PyrPI); - v2: PyrPI -> EIP + $Pyr; compartment_*(v2_k2f*PyrPI - v2_k2r*Pyr*EIP); - v3: HPr + EIP -> EIPHPr; compartment_*(v3_k3f*EIP*HPr - v3_k3r*EIPHPr); - v4: EIPHPr -> HPrP + EI; compartment_*(v4_k4f*EIPHPr - v4_k4r*EI*HPrP); - v5: HPrP + EIIA -> HPrPIIA; compartment_*(v5_k5f*HPrP*EIIA - v5_k5r*HPrPIIA); - v6: HPrPIIA -> EIIAP + HPr; compartment_*(v6_k6f*HPrPIIA - v6_k6r*HPr*EIIAP); - v7: EIICB + EIIAP -> EIIAPIICB; compartment_*(v7_k7f*EIIAP*EIICB - v7_k7r*EIIAPIICB); - v8: EIIAPIICB -> EIICBP + EIIA; compartment_*(v8_k8f*EIIAPIICB - v8_k8r*EIIA*EIICBP); - v9: EIICBP + $Glc -> EIICBPGlc; compartment_*(v9_k9f*EIICBP*Glc - v9_k9r*EIICBPGlc); - v10: EIICBPGlc -> EIICB + $GlcP; compartment_*(v10_k10f*EIICBPGlc - v10_k10r*EIICB*GlcP); - - // Species initializations: - EI = 3; - PyrPI = 0; - EIP = 2; - HPr = 25; - EIPHPr = 0; - HPrP = 25; - EIIA = 20; - HPrPIIA = 0; - EIIAP = 20; - EIICB = 5; - EIIAPIICB = 0; - EIICBP = 5; - EIICBPGlc = 0; - PEP = 2800; - Pyr = 900; - GlcP = 50; - Glc = 500; - - // Compartment initializations: - compartment_ = 1; - - // Variable initializations: - v1_k1f = 1960; - v1_k1r = 480000; - v2_k2f = 108000; - v2_k2r = 294; - v3_k3f = 14000; - v3_k3r = 14000; - v4_k4f = 84000; - v4_k4r = 3360; - v5_k5f = 21960; - v5_k5r = 21960; - v6_k6f = 4392; - v6_k6r = 3384; - v7_k7f = 880; - v7_k7r = 880; - v8_k8f = 2640; - v8_k8r = 960; - v9_k9f = 260; - v9_k9r = 389; - v10_k10f = 4800; - v10_k10r = 0.0054; - - // Other declarations: - const compartment_; - - // Unit definitions: - unit substance = 1e-6 mole; - unit time_unit = 60 second; - - // Display Names: - substance is "micromole (default)"; - time_unit is "minute (default)"; - compartment_ is "cell"; - - // CV terms: - compartment_ hypernym "http://identifiers.org/go/GO:0005623" - EI hypernym "http://identifiers.org/uniprot/P08839" - PyrPI part "http://identifiers.org/uniprot/P08839", - "http://identifiers.org/kegg.compound/C00074", - "http://identifiers.org/chebi/CHEBI:18021" - PyrPI part "http://identifiers.org/chebi/CHEBI:18021", - "http://identifiers.org/uniprot/P08839", - "http://identifiers.org/kegg.compound/C00615" - EIP hypernym "http://identifiers.org/uniprot/P08839" - HPr identity "http://identifiers.org/uniprot/P07006" - EIPHPr part "http://identifiers.org/uniprot/P07006", - "http://identifiers.org/uniprot/P08839" - HPrP part "http://identifiers.org/uniprot/P07006", - "http://identifiers.org/kegg.compound/C00615" - EIIA identity "http://identifiers.org/uniprot/P69783" - HPrPIIA part "http://identifiers.org/uniprot/P07006", - "http://identifiers.org/uniprot/P69783" - EIIAP identity "http://identifiers.org/uniprot/P69783" - EIICB identity "http://identifiers.org/uniprot/P69786" - EIIAPIICB identity "http://identifiers.org/uniprot/P69786", - "http://identifiers.org/uniprot/P69783" - EIICBP identity "http://identifiers.org/uniprot/P69786" - EIICBPGlc part "http://identifiers.org/chebi/CHEBI:17234", - "http://identifiers.org/uniprot/P69786", - "http://identifiers.org/kegg.compound/C00293" - PEP identity "http://identifiers.org/chebi/CHEBI:18021", - "http://identifiers.org/kegg.compound/C00074" - Pyr identity "http://identifiers.org/chebi/CHEBI:15361", - "http://identifiers.org/kegg.compound/C00022" - GlcP identity "http://identifiers.org/chebi/CHEBI:14314", - "http://identifiers.org/kegg.compound/C00092" - Glc identity "http://identifiers.org/chebi/CHEBI:17234", - "http://identifiers.org/kegg.compound/C00293" - v1 hypernym "http://identifiers.org/ec-code/2.7.3.9", - "http://identifiers.org/go/GO:0018106", - "http://identifiers.org/go/GO:0008965", - "http://identifiers.org/go/GO:0016772" - v1 identity "http://identifiers.org/kegg.reaction/R02628" - v2 hypernym "http://identifiers.org/ec-code/2.7.3.9", - "http://identifiers.org/go/GO:0016772", - "http://identifiers.org/go/GO:0008965", - "http://identifiers.org/go/GO:0018106" - v2 identity "http://identifiers.org/kegg.reaction/R02628" - v3 hypernym "http://identifiers.org/go/GO:0016772", - "http://identifiers.org/go/GO:0018106" - v3 identity "http://identifiers.org/intact/EBI-902828" - v4 hypernym "http://identifiers.org/go/GO:0016772", - "http://identifiers.org/go/GO:0018106" - v4 identity "http://identifiers.org/intact/EBI-902828" - v5 hypernym "http://identifiers.org/go/GO:0018106", - "http://identifiers.org/go/GO:0016772" - v5 identity "http://identifiers.org/intact/EBI-903339" - v6 hypernym "http://identifiers.org/go/GO:0018106", - "http://identifiers.org/go/GO:0016772" - v6 identity "http://identifiers.org/intact/EBI-903339" - v7 hypernym "http://identifiers.org/go/GO:0018106", - "http://identifiers.org/go/GO:0016772" - v7 identity "http://identifiers.org/intact/EBI-903826" - v8 identity "http://identifiers.org/intact/EBI-903826" - v8 hypernym "http://identifiers.org/go/GO:0016772", - "http://identifiers.org/go/GO:0018106" - v9 hypernym "http://identifiers.org/go/GO:0016772", - "http://identifiers.org/go/GO:0046835" - v10 hypernym "http://identifiers.org/go/GO:0016772", - "http://identifiers.org/go/GO:0046835" -end - -Rohwer2000_Phosphotransferase_System is "Rohwer2000_Phosphotransferase_System" - -Rohwer2000_Phosphotransferase_System model_entity_is "http://identifiers.org/biomodels.db/MODEL6621395815" -Rohwer2000_Phosphotransferase_System model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000038" -Rohwer2000_Phosphotransferase_System description "http://identifiers.org/pubmed/10889194" -Rohwer2000_Phosphotransferase_System identity "http://identifiers.org/kegg.pathway/eco02060" -Rohwer2000_Phosphotransferase_System hypernym "http://identifiers.org/go/GO:0009401", - "http://identifiers.org/go/GO:0010827" -Rohwer2000_Phosphotransferase_System taxon "http://identifiers.org/taxonomy/562" -Rohwer2000_Phosphotransferase_System property "http://identifiers.org/mamo/MAMO_0000046" diff --git a/BioModelsRAG/data/BIOMD0000000039.txt b/BioModelsRAG/data/BIOMD0000000039.txt deleted file mode 100644 index 490f122b72b13fc46fe79b8f8bd6792548b6f7fb..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000039.txt +++ /dev/null @@ -1,95 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Marhl_Calcium_Oscillations_role_of_mitochondria_and_cytosolic_proteins() - - // Compartments and Species: - compartment Cytosol, Endoplasmic_Reticulum, Mitochondria; - species Ca_cyt in Cytosol, CaER in Endoplasmic_Reticulum, CaM in Mitochondria; - species CaPr in Cytosol, Pr in Cytosol; - - // Reactions: - v1: 0.25 CaER => Ca_cyt; Cytosol*(v1_Kch*Ca_cyt^2*(CaER - Ca_cyt)/(v1_K1^2 + Ca_cyt^2)); - v3: 0.25 CaER => Ca_cyt; Cytosol*v3_Kleak*(CaER - Ca_cyt); - v5: Ca_cyt => 0.25 CaER; Endoplasmic_Reticulum*v5_Kpump*Ca_cyt; - v7: 0.25 CaM => Ca_cyt; Cytosol*CaM*(v7_Kout*Ca_cyt^2/(v7_K3^2 + Ca_cyt^2) + v7_Km); - v9: Ca_cyt => 0.25 CaM; Mitochondria*(v9_Kin*Ca_cyt^8/(v9_K2^8 + Ca_cyt^8)); - v11: CaPr => Pr + Ca_cyt; Cytosol*v11_Kminus*CaPr; - v12: Pr + Ca_cyt => CaPr; Cytosol*v12_Kplus*Ca_cyt*Pr; - - // Species initializations: - Ca_cyt = 0.35; - CaER = 0.76; - CaM = 0.29; - CaPr = 85.45; - Pr = 34.55; - - // Compartment initializations: - Cytosol = 1; - Endoplasmic_Reticulum = 1; - Mitochondria = 1; - - // Variable initializations: - v1_Kch = 4100; - v1_K1 = 5; - v3_Kleak = 0.05; - v5_Kpump = 20; - v7_Kout = 125; - v7_K3 = 5; - v7_Km = 0.00625; - v9_Kin = 300; - v9_K2 = 0.8; - v11_Kminus = 0.01; - v12_Kplus = 0.1; - - // Other declarations: - const Cytosol, Endoplasmic_Reticulum, Mitochondria; - - // Unit definitions: - unit substance = 1e-6 mole; - - // Display Names: - substance is "micromole (default)"; - v1 is "Jch"; - v3 is "Jleak"; - v5 is "Jpump"; - v7 is "Jout"; - v9 is "Jin"; - v11 is "dissociation of CaPr"; - v12 is "binding of Ca on Pr"; - - // CV terms: - Cytosol identity "http://identifiers.org/go/GO:0005829" - Endoplasmic_Reticulum identity "http://identifiers.org/go/GO:0005790" - Mitochondria identity "http://identifiers.org/go/GO:0005739" - Ca_cyt identity "http://identifiers.org/chebi/CHEBI:29108" - CaER identity "http://identifiers.org/chebi/CHEBI:29108" - CaM identity "http://identifiers.org/chebi/CHEBI:29108" - CaPr part "http://identifiers.org/chebi/CHEBI:29108", - "http://identifiers.org/kegg.compound/C00017" - Pr hypernym "http://identifiers.org/kegg.compound/C00017", - "http://identifiers.org/chebi/CHEBI:16541" - v1 hypernym "http://identifiers.org/go/GO:0051482", - "http://identifiers.org/go/GO:0006816" - v3 hypernym "http://identifiers.org/go/GO:0006816", - "http://identifiers.org/go/GO:0007204" - v5 hypernym "http://identifiers.org/go/GO:0051481", - "http://identifiers.org/go/GO:0006816" - v7 identity "http://identifiers.org/go/GO:0006816", - "http://identifiers.org/go/GO:0007204" - v9 hypernym "http://identifiers.org/go/GO:0006816", - "http://identifiers.org/go/GO:0051481" - v11 hypernym "http://identifiers.org/go/GO:0007204" - v12 hypernym "http://identifiers.org/go/GO:0005509", - "http://identifiers.org/go/GO:0051481" -end - -Marhl_Calcium_Oscillations_role_of_mitochondria_and_cytosolic_proteins is "Marhl2000_CaOscillations" - -Marhl_Calcium_Oscillations_role_of_mitochondria_and_cytosolic_proteins model_entity_is "http://identifiers.org/biomodels.db/MODEL6621933497" -Marhl_Calcium_Oscillations_role_of_mitochondria_and_cytosolic_proteins model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000039" -Marhl_Calcium_Oscillations_role_of_mitochondria_and_cytosolic_proteins description "http://identifiers.org/pubmed/11004387" -Marhl_Calcium_Oscillations_role_of_mitochondria_and_cytosolic_proteins origin "http://identifiers.org/pubmed/17029696", - "http://identifiers.org/pubmed/12362939" -Marhl_Calcium_Oscillations_role_of_mitochondria_and_cytosolic_proteins taxon "http://identifiers.org/taxonomy/8355" -Marhl_Calcium_Oscillations_role_of_mitochondria_and_cytosolic_proteins identity "http://identifiers.org/kegg.pathway/hsa04020", - "http://identifiers.org/go/GO:0019722", - "http://identifiers.org/go/GO:0048016" diff --git a/BioModelsRAG/data/BIOMD0000000040.txt b/BioModelsRAG/data/BIOMD0000000040.txt deleted file mode 100644 index 6eb433a1e3e28d842399fb2265041b233e86c51b..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000040.txt +++ /dev/null @@ -1,61 +0,0 @@ -// Created by libAntimony v2.13.0 - -// Warnings from automatic translation: -// Unable to set the stoichiometry math for the product Br in reaction Reaction5 because stoichiometry math is not a defined concept in Antimony. - -model *Field1974_Oregonator() - - // Compartments and Species: - compartment BZ; - species Br in BZ, $BrO3 in BZ, Ce in BZ, HBrO2 in BZ, $HOBr in BZ; - - // Reactions: - Reaction1: Br + $BrO3 => HBrO2 + $HOBr; Br*BrO3*Reaction1_k1*BZ; - Reaction2: Br + HBrO2 => 2 $HOBr; Br*HBrO2*Reaction2_k2*BZ; - Reaction3: $BrO3 + HBrO2 => Ce + 2 HBrO2; BrO3*HBrO2*Reaction3_k3*BZ; - Reaction4: 2 HBrO2 => $BrO3 + $HOBr; HBrO2^2*Reaction4_k4*BZ; - Reaction5: Ce => Br; Ce*Reaction5_k5*BZ; - - // Species initializations: - Br = 1e-07; - BrO3 = 0.06; - Ce = 0.05; - HBrO2 = 5e-11; - HOBr = 0; - - // Compartment initializations: - BZ = 1; - - // Variable initializations: - f = 1; - Reaction1_k1 = 1.34; - Reaction2_k2 = 1600000000; - Reaction3_k3 = 8000; - Reaction4_k4 = 40000000; - Reaction5_k5 = 1; - - // Other declarations: - const BZ, f; - - // Display Names: - Br is "Br-"; - BrO3 is "BrO3-"; - Ce is "Ce4+"; - Reaction1 is "M1"; - Reaction2 is "M2"; - Reaction3 is "M3"; - Reaction4 is "M4"; - Reaction5 is "M5"; - - // CV terms: - Br identity "http://identifiers.org/chebi/CHEBI:15858" - BrO3 identity "http://identifiers.org/chebi/CHEBI:29223" -end - -Field1974_Oregonator is "Field1974_Oregonator" - -Field1974_Oregonator model_entity_is "http://identifiers.org/biomodels.db/MODEL6622000424" -Field1974_Oregonator model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000040" -Field1974_Oregonator description "http://identifiers.org/doi/10.1063/1.1681288" -Field1974_Oregonator taxon "http://identifiers.org/taxonomy/131567" -Field1974_Oregonator hypernym "http://identifiers.org/go/GO:0007622" diff --git a/BioModelsRAG/data/BIOMD0000000041.txt b/BioModelsRAG/data/BIOMD0000000041.txt deleted file mode 100644 index 4460529e5a9c3b76a17fb5ade2c79958b9307a13..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000041.txt +++ /dev/null @@ -1,127 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Kongas___Van_Beek() - - // Compartments and Species: - compartment IMS, CYT; - species ADPi in IMS, ATPi in IMS, Cri in IMS, PCri in IMS, PCr in CYT, ADP in CYT; - species ATP in CYT, Cr in CYT, Pi in IMS, P in CYT; - - // Reactions: - OxPhos: ADPi + Pi -> ATPi; IMS*(OxPhos_V_1*ADPi*Pi/(OxPhos_Ka_1*OxPhos_Kb_1*(1 + ADPi/OxPhos_Ka_1 + Pi/OxPhos_Kb_1 + ADPi*Pi/(OxPhos_Ka_1*OxPhos_Kb_1)))); - MiCK: ATPi + Cri -> ADPi + PCri; IMS*((MiCK_Vf_2*ATPi*Cri/(MiCK_Kia_2*MiCK_Kb_2) - MiCK_Vb_2*ADPi*PCri/(MiCK_Kic_2*MiCK_Kd_2))/(1 + Cri/MiCK_Kib_2 + PCri/MiCK_Kid_2 + ATPi*(1/MiCK_Kia_2 + Cri/(MiCK_Kia_2*MiCK_Kb_2)) + ADPi*(1/MiCK_Kic_2 + Cri/(MiCK_Kic_2*MiCK_Kib_2) + PCri/(MiCK_Kid_2*(MiCK_Kic_2*MiCK_Kd_2/MiCK_Kid_2))))); - MMCK: ATP + Cr -> PCr + ADP; CYT*((MMCK_Vf_3*ATP*Cr/(MMCK_Kia_3*MMCK_Kb_3) - MMCK_Vb_3*ADP*PCr/(MMCK_Kic_3*MMCK_Kd_3))/(1 + Cr/MMCK_Kib_3 + PCr/MMCK_Kid_3 + ATP*(1/MMCK_Kia_3 + Cr/(MMCK_Kia_3*MMCK_Kb_3)) + ADP*(1/MMCK_Kic_3 + Cr/(MMCK_Kic_3*MMCK_Kib_3) + PCr/(MMCK_Kid_3*(MMCK_Kic_3*MMCK_Kd_3/MMCK_Kid_3))))); - ATPase: ATP => ADP + P; CYT*ATPase_v_4*ATP; - Pi_diffusion: Pi -> P; IMS*Pi_diffusion_k2_5*Pi - CYT*Pi_diffusion_k2_5*P; - Cr_diffusion: Cri -> Cr; IMS*Cr_diffusion_k1_6*Cri - CYT*Cr_diffusion_k1_6*Cr; - ADP_diffusion: ADPi -> ADP; IMS*ADP_diffusion_k1_7*ADPi - CYT*ADP_diffusion_k1_7*ADP; - PCr_diffusion: PCri -> PCr; IMS*PCr_diffusion_k1_8*PCri - CYT*PCr_diffusion_k1_8*PCr; - ATP_diffusion: ATPi -> ATP; IMS*ATP_diffusion_k1_9*ATPi - CYT*ATP_diffusion_k1_9*ATP; - - // Species initializations: - ADPi = 0; - ATPi = 0; - Cri = 0; - PCri = 0; - PCr = 0; - ADP = 0; - ATP = 9700; - Cr = 26000; - Pi = 32000; - P = 0; - - // Compartment initializations: - IMS = 0.0625; - CYT = 0.75; - - // Variable initializations: - OxPhos_V_1 = 4600; - OxPhos_Ka_1 = 800; - OxPhos_Kb_1 = 20; - MiCK_Vf_2 = 2658; - MiCK_Kia_2 = 750; - MiCK_Kb_2 = 5200; - MiCK_Vb_2 = 11160; - MiCK_Kic_2 = 204.8; - MiCK_Kd_2 = 500; - MiCK_Kib_2 = 28800; - MiCK_Kid_2 = 1600; - MMCK_Vf_3 = 6966; - MMCK_Kia_3 = 900; - MMCK_Kb_3 = 15500; - MMCK_Vb_3 = 29250; - MMCK_Kic_3 = 222.4; - MMCK_Kd_3 = 1670; - MMCK_Kib_3 = 34900; - MMCK_Kid_3 = 4730; - ATPase_v_4 = 4600; - Pi_diffusion_k2_5 = 18.4; - Cr_diffusion_k1_6 = 14.6; - ADP_diffusion_k1_7 = 8.16; - PCr_diffusion_k1_8 = 14.6; - ATP_diffusion_k1_9 = 8.16; - - // Other declarations: - const IMS, CYT; - - // Unit definitions: - unit substance = 1e-6 mole; - - // Display Names: - substance is "micromole"; - Pi is "Pii"; - P is "Pi"; - OxPhos is "Vsyn"; - MiCK is "Vmick"; - MMCK is "Vmmck"; - ATPase is "Vhyd"; - Pi_diffusion is "Jpi"; - Cr_diffusion is "Jcr"; - ADP_diffusion is "Jadp"; - PCr_diffusion is "Jpcr"; - ATP_diffusion is "Jatp"; - - // CV terms: - IMS hypernym "http://identifiers.org/go/GO:0005758" - CYT hypernym "http://identifiers.org/go/GO:0005829" - ADPi identity "http://identifiers.org/chebi/CHEBI:16761", - "http://identifiers.org/kegg.compound/C00008" - ATPi identity "http://identifiers.org/chebi/CHEBI:15422", - "http://identifiers.org/kegg.compound/C00002" - Cri identity "http://identifiers.org/chebi/CHEBI:16919", - "http://identifiers.org/kegg.compound/C00300" - PCri identity "http://identifiers.org/chebi/CHEBI:17287", - "http://identifiers.org/kegg.compound/C02305" - PCr identity "http://identifiers.org/chebi/CHEBI:17287", - "http://identifiers.org/kegg.compound/C02305" - ADP identity "http://identifiers.org/chebi/CHEBI:16761", - "http://identifiers.org/kegg.compound/C00008" - ATP identity "http://identifiers.org/chebi/CHEBI:15422", - "http://identifiers.org/kegg.compound/C00002" - Cr identity "http://identifiers.org/chebi/CHEBI:16919", - "http://identifiers.org/kegg.compound/C00300" - Pi identity "http://identifiers.org/chebi/CHEBI:18367", - "http://identifiers.org/kegg.compound/C00009" - P identity "http://identifiers.org/chebi/CHEBI:18367", - "http://identifiers.org/kegg.compound/C00009" - OxPhos hypernym "http://identifiers.org/go/GO:0006119" - MiCK hypernym "http://identifiers.org/ec-code/2.7.3.2", - "http://identifiers.org/go/GO:0004111" - MMCK hypernym "http://identifiers.org/ec-code/2.7.3.2", - "http://identifiers.org/go/GO:0004111" - ATPase hypernym "http://identifiers.org/go/GO:0016887" - Pi_diffusion hypernym "http://identifiers.org/go/GO:0006817" - Cr_diffusion hypernym "http://identifiers.org/go/GO:0015881" - ADP_diffusion hypernym "http://identifiers.org/go/GO:0015866" - PCr_diffusion hypernym "http://identifiers.org/go/GO:0015881" - ATP_diffusion hypernym "http://identifiers.org/go/GO:0015867" -end - -Kongas___Van_Beek is "Kongas2007 - Creatine Kinase in energy metabolic signaling in muscle" - -Kongas___Van_Beek model_entity_is "http://identifiers.org/biomodels.db/MODEL6622188656" -Kongas___Van_Beek model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000041" -Kongas___Van_Beek description "http://identifiers.org/doi/10.1038/npre.2007.1317.1" -Kongas___Van_Beek origin "http://identifiers.org/pubmed/10751324" -Kongas___Van_Beek hypernym "http://identifiers.org/go/GO:0006600", - "http://identifiers.org/go/GO:0046034" -Kongas___Van_Beek taxon "http://identifiers.org/taxonomy/9984" diff --git a/BioModelsRAG/data/BIOMD0000000042.txt b/BioModelsRAG/data/BIOMD0000000042.txt deleted file mode 100644 index a070201a42fcc3a9ef2840f6c972544ba8a96ff9..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000042.txt +++ /dev/null @@ -1,189 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Glycolysis_Nielsen() - - // Compartments and Species: - compartment compartment_; - species ATP in compartment_, ADP in compartment_, AMP in compartment_, GLC in compartment_; - species F6P in compartment_, FBP in compartment_, GAP in compartment_, NAD in compartment_; - species NADH in compartment_, DPG in compartment_, PEP in compartment_; - species PYR in compartment_, ACA in compartment_, EtOH in compartment_; - species P in compartment_; - - // Reactions: - ATPflow: -> ATP; compartment_*(3.5 - ATP)*flow; - ADPflow: -> ADP; compartment_*(1.1 - ADP)*flow; - NADHflow: -> NADH; compartment_*(0.24 - NADH)*flow; - NADflow: -> NAD; compartment_*(4 - NAD)*flow; - GLCflow: -> GLC; compartment_*(50 - GLC)*flow; - F6Pflow: F6P => ; compartment_*F6P*flow; - FBPflow: FBP => ; compartment_*FBP*flow; - GAPflow: GAP => ; compartment_*GAP*flow; - DPGflow: DPG => ; compartment_*DPG*flow; - PEPflow: PEP => ; compartment_*PEP*flow; - PYRflow: PYR => ; compartment_*PYR*flow; - ACAflow: ACA => ; compartment_*ACA*flow; - EtOHflow: EtOH => ; compartment_*EtOH*flow; - AMPflow: AMP => ; compartment_*AMP*flow; - Pflow: P => ; compartment_*P*flow; - reaction_1: GLC + ATP => F6P + ADP; compartment_*(V1*ATP*GLC/((K1GLC + GLC)*(K1ATP + ATP))); - reaction_2: F6P + ATP => FBP + ADP; compartment_*(V2*ATP*F6P^2/((K2*(1 + k2*(ATP/AMP)^2) + F6P^2)*(K2ATP + ATP))); - reaction_3: FBP -> 2 GAP; compartment_*(k3f*FBP - k3b*GAP^2); - reaction_4: GAP + NAD => DPG + NADH; compartment_*(V4*NAD*GAP/((K4GAP + GAP)*(K4NAD + NAD))); - reaction_5: DPG + ADP -> PEP + ATP; compartment_*(k5f*DPG*ADP - k5b*PEP*ATP); - reaction_6: PEP + ADP => PYR + ATP; compartment_*(V6*ADP*PEP/((K6PEP + PEP)*(K6ADP + ADP))); - reaction_7: PYR => ACA; compartment_*(V7*PYR/(K7PYR + PYR)); - reaction_8: ACA + NADH -> EtOH + NAD; compartment_*(k8f*NADH*ACA - k8b*NAD*EtOH); - reaction_9: AMP + ATP -> 2 ADP; compartment_*(k9f*AMP*ATP - k9b*ADP^2); - reaction_10: F6P => P; compartment_*k10*F6P; - - // Species initializations: - ATP = 4.49064/compartment_; - ADP = 0.108367/compartment_; - AMP = 0.00261149/compartment_; - GLC = 0.0112817/compartment_; - F6P = 0.65939/compartment_; - FBP = 0.00770135/compartment_; - GAP = 0.00190919/compartment_; - NAD = 3.62057/compartment_; - NADH = 0.616118/compartment_; - DPG = 0.299109/compartment_; - PEP = 0.0021125/compartment_; - PYR = 0.00422702/compartment_; - ACA = 0.0738334/compartment_; - EtOH = 0.33981/compartment_; - P = 0; - - // Compartment initializations: - compartment_ = 1; - - // Variable initializations: - V1 = 0.5; - K1GLC = 0.1; - K1ATP = 0.063; - V2 = 1.5; - K2 = 0.0016; - k2 = 0.017; - K2ATP = 0.01; - k3f = 1; - k3b = 50; - V4 = 10; - K4GAP = 1; - K4NAD = 1; - k5f = 1; - k5b = 0.5; - V6 = 10; - K6PEP = 0.2; - K6ADP = 0.3; - V7 = 2; - K7PYR = 0.3; - k8f = 1; - k8b = 0.000143; - k9f = 10; - k9b = 10; - k10 = 0.05; - flow = 0.011; - - // Other declarations: - const compartment_, V1, K1GLC, K1ATP, V2, K2, k2, K2ATP, k3f, k3b, V4, K4GAP; - const K4NAD, k5f, k5b, V6, K6PEP, K6ADP, V7, K7PYR, k8f, k8b, k9f, k9b; - const k10, flow; - - // Unit definitions: - unit substance = 1e-3 mole; - unit time_unit = 60 second; - - // Display Names: - substance is "millimole"; - time_unit is "minute"; - - // CV terms: - compartment_ hypernym "http://identifiers.org/go/GO:0005737" - ATP identity "http://identifiers.org/chebi/CHEBI:15422", - "http://identifiers.org/kegg.compound/C00002" - ADP identity "http://identifiers.org/chebi/CHEBI:16761", - "http://identifiers.org/kegg.compound/C00008" - AMP identity "http://identifiers.org/chebi/CHEBI:16027", - "http://identifiers.org/kegg.compound/C00020" - GLC identity "http://identifiers.org/chebi/CHEBI:17234", - "http://identifiers.org/kegg.compound/C00293" - F6P identity "http://identifiers.org/chebi/CHEBI:20935", - "http://identifiers.org/kegg.compound/C05345" - FBP identity "http://identifiers.org/chebi/CHEBI:16905", - "http://identifiers.org/kegg.compound/C05378" - GAP identity "http://identifiers.org/chebi/CHEBI:29052", - "http://identifiers.org/kegg.compound/C00118" - NAD identity "http://identifiers.org/chebi/CHEBI:15846", - "http://identifiers.org/kegg.compound/C00003" - NADH identity "http://identifiers.org/chebi/CHEBI:16908", - "http://identifiers.org/kegg.compound/C00004" - DPG identity "http://identifiers.org/chebi/CHEBI:16001", - "http://identifiers.org/kegg.compound/C00236" - PEP identity "http://identifiers.org/chebi/CHEBI:18021", - "http://identifiers.org/kegg.compound/C00074" - PYR identity "http://identifiers.org/chebi/CHEBI:15361", - "http://identifiers.org/kegg.compound/C00022" - ACA identity "http://identifiers.org/chebi/CHEBI:15343", - "http://identifiers.org/kegg.compound/C00084" - EtOH identity "http://identifiers.org/chebi/CHEBI:16236", - "http://identifiers.org/kegg.compound/C00469" - ATPflow hypernym "http://identifiers.org/go/GO:0006754" - ADPflow hypernym "http://identifiers.org/go/GO:0006172" - NADHflow hypernym "http://identifiers.org/go/GO:0006735" - NADflow hypernym "http://identifiers.org/go/GO:0009435" - GLCflow hypernym "http://identifiers.org/go/GO:0046323" - F6Pflow hypernym "http://identifiers.org/go/GO:0006002" - FBPflow hypernym "http://identifiers.org/go/GO:0030388" - GAPflow hypernym "http://identifiers.org/go/GO:0019683" - PYRflow hypernym "http://identifiers.org/go/GO:0042867" - ACAflow hypernym "http://identifiers.org/go/GO:0046187" - EtOHflow hypernym "http://identifiers.org/go/GO:0006068" - AMPflow hypernym "http://identifiers.org/go/GO:0006196" - reaction_1 homolog "http://identifiers.org/reactome/REACT_1164" - reaction_1 part "http://identifiers.org/ec-code/2.7.1.2", - "http://identifiers.org/ec-code/5.3.1.9" - reaction_1 part "http://identifiers.org/kegg.reaction/R00771", - "http://identifiers.org/kegg.reaction/R00299" - reaction_2 homolog "http://identifiers.org/reactome/REACT_1840" - reaction_2 hypernym "http://identifiers.org/ec-code/2.7.1.11", - "http://identifiers.org/kegg.reaction/R00756" - reaction_3 homolog "http://identifiers.org/reactome/REACT_1693" - reaction_3 part "http://identifiers.org/kegg.reaction/R01070", - "http://identifiers.org/kegg.reaction/R01015" - reaction_3 part "http://identifiers.org/ec-code/5.3.1.1", - "http://identifiers.org/ec-code/4.1.2.13" - reaction_4 homolog "http://identifiers.org/reactome/REACT_587" - reaction_4 hypernym "http://identifiers.org/ec-code/1.2.1.12", - "http://identifiers.org/kegg.reaction/R01061" - reaction_5 part "http://identifiers.org/ec-code/5.4.2.1", - "http://identifiers.org/ec-code/2.7.2.3", - "http://identifiers.org/ec-code/4.2.1.11" - reaction_5 part "http://identifiers.org/kegg.reaction/R00658", - "http://identifiers.org/kegg.reaction/R01512", - "http://identifiers.org/kegg.reaction/R01518" - reaction_5 part "http://identifiers.org/reactome/REACT_1771", - "http://identifiers.org/reactome/REACT_1400" - reaction_6 version "http://identifiers.org/ec-code/2.7.1.40", - "http://identifiers.org/kegg.reaction/R00200" - reaction_6 homolog "http://identifiers.org/reactome/REACT_1911" - reaction_7 hypernym "http://identifiers.org/ec-code/4.1.1.1", - "http://identifiers.org/kegg.reaction/R00224" - reaction_8 hypernym "http://identifiers.org/ec-code/1.1.1.71", - "http://identifiers.org/kegg.reaction/R00754" - reaction_8 homolog "http://identifiers.org/reactome/REACT_799" - reaction_9 hypernym "http://identifiers.org/ec-code/2.7.4.3", - "http://identifiers.org/kegg.reaction/R00127" - reaction_10 hypernym "http://identifiers.org/go/GO:0006001" - reaction_10 homolog "http://identifiers.org/reactome/REACT_1571" -end - -Glycolysis_Nielsen is "Nielsen1998_Glycolysis" - -Glycolysis_Nielsen model_entity_is "http://identifiers.org/biomodels.db/MODEL6622455387" -Glycolysis_Nielsen model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000042" -Glycolysis_Nielsen description "http://identifiers.org/pubmed/17029704" -Glycolysis_Nielsen origin "http://identifiers.org/pubmed/6454892", - "http://identifiers.org/pubmed/8061224" -Glycolysis_Nielsen homolog "http://identifiers.org/reactome/REACT_1383" -Glycolysis_Nielsen taxon "http://identifiers.org/taxonomy/4932" -Glycolysis_Nielsen identity "http://identifiers.org/kegg.pathway/sce00010" -Glycolysis_Nielsen hypernym "http://identifiers.org/go/GO:0006096" diff --git a/BioModelsRAG/data/BIOMD0000000043.txt b/BioModelsRAG/data/BIOMD0000000043.txt deleted file mode 100644 index 487ce8eb29ea2838cf5687693547e4971df59e4c..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000043.txt +++ /dev/null @@ -1,88 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Goldbeter_Calcium_Oscillation_based_on_CICR_AND_CA_channel_inhibition() - - // Compartments and Species: - compartment extracellular, cytosol, intravesicular; - species EC in extracellular, Z in cytosol, Rho in cytosol, Y in intravesicular; - species Fraction_Inactive_Channels in cytosol; - - // Reactions: - vin: EC => Z; cytosol*(vin_v0 + vin_v1*beta); - v2: Z => Y; intravesicular*(v2_Vm2*Z^2/(v2_K2^2 + Z^2)); - v3: Y => Z; cytosol*(beta*(Rho*(a/d)*Z^4/(1 + (a/d)*Z^4))*v3_Vm3*Y^2/(v3_Ky^2 + Y^2)); - v4: Y => Z; cytosol*v4_Kf*Y; - v5: Z => EC; extracellular*v5_K*Z; - v6: Rho => Fraction_Inactive_Channels; cytosol*v6_Kd*Z^4*Rho; - v7: Fraction_Inactive_Channels => Rho; cytosol*v7_Kr*(1 - Rho); - - // Species initializations: - EC = 0; - Z = 0; - Rho = 0; - Y = 0.36; - Fraction_Inactive_Channels = 0; - - // Compartment initializations: - extracellular = 1; - cytosol = 1; - intravesicular = 1; - - // Variable initializations: - a = 40000; - d = 100; - beta = 1; - vin_v0 = 1; - vin_v1 = 1; - v2_Vm2 = 6.5; - v2_K2 = 0.1; - v3_Vm3 = 50; - v3_Ky = 0.2; - v4_Kf = 1; - v5_K = 10; - v6_Kd = 5000; - v7_Kr = 5; - - // Other declarations: - const extracellular, cytosol, intravesicular, a, d, beta; - - // Unit definitions: - unit substance = 1e-6 mole; - unit time_unit = 60 second; - - // Display Names: - substance is "micromole (default)"; - time_unit is "minute (default)"; - - // CV terms: - extracellular hypernym "http://identifiers.org/obo.go/GO:0005615" - cytosol hypernym "http://identifiers.org/obo.go/GO:0005829" - intravesicular hypernym "http://identifiers.org/obo.go/GO:0005790" - EC identity "http://identifiers.org/chebi/CHEBI:29108", - "http://identifiers.org/kegg.compound/C00076" - Z identity "http://identifiers.org/chebi/CHEBI:29108", - "http://identifiers.org/kegg.compound/C00076" - Rho hypernym "http://identifiers.org/interpro/IPR016093", - "http://identifiers.org/interpro/IPR000493" - Y identity "http://identifiers.org/chebi/CHEBI:29108", - "http://identifiers.org/kegg.compound/C00076" - Fraction_Inactive_Channels hypernym "http://identifiers.org/interpro/IPR000493", - "http://identifiers.org/pirsf/PIRSF002433" - vin hypernym "http://identifiers.org/obo.go/GO:0006816", - "http://identifiers.org/obo.go/GO:0007204" - v2 hypernym "http://identifiers.org/obo.go/GO:0051481" - v3 hypernym "http://identifiers.org/obo.go/GO:0007204" - v4 hypernym "http://identifiers.org/obo.go/GO:0007204" - v5 hypernym "http://identifiers.org/obo.go/GO:0051481" - v6 hypernym "http://identifiers.org/obo.go/GO:0005220" - v7 hypernym "http://identifiers.org/obo.go/GO:0005220" -end - -Goldbeter_Calcium_Oscillation_based_on_CICR_AND_CA_channel_inhibition is "Borghans1997 - Calcium Oscillation - Model 1" - -Goldbeter_Calcium_Oscillation_based_on_CICR_AND_CA_channel_inhibition model_entity_is "http://identifiers.org/biomodels.db/MODEL6622689184" -Goldbeter_Calcium_Oscillation_based_on_CICR_AND_CA_channel_inhibition model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000043" -Goldbeter_Calcium_Oscillation_based_on_CICR_AND_CA_channel_inhibition description "http://identifiers.org/pubmed/17029867" -Goldbeter_Calcium_Oscillation_based_on_CICR_AND_CA_channel_inhibition hypernym "http://identifiers.org/obo.go/GO:0048016", - "http://identifiers.org/obo.go/GO:0019722" -Goldbeter_Calcium_Oscillation_based_on_CICR_AND_CA_channel_inhibition identity "http://identifiers.org/kegg.pathway/rno04020" -Goldbeter_Calcium_Oscillation_based_on_CICR_AND_CA_channel_inhibition taxon "http://identifiers.org/taxonomy/10114" diff --git a/BioModelsRAG/data/BIOMD0000000044.txt b/BioModelsRAG/data/BIOMD0000000044.txt deleted file mode 100644 index 80162dbe39ebba50cbe5d6dc9562bd99e7603774..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000044.txt +++ /dev/null @@ -1,129 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Goldbeter_Calcium_Oscillation_based_on_CICR_AND_CA_Activated_degradation_of_IP3() - - // Compartments and Species: - compartment extracellular, cytosol, intravesicular; - species EC in extracellular, Z in cytosol, A in cytosol, Y in intravesicular; - - // Reactions: - vin: EC => Z; cytosol*(vin_v0 + vin_v1*beta); - v2: Z => Y; intravesicular*(v2_Vm2*Z^2/(v2_K2^2 + Z^2)); - v3: Y => Z; cytosol*v3_Vm3*A^4*Y^2*Z^4/((v3_Ka^4 + A^4)*(v3_Ky^2 + Y^2)*(v3_Kz^4 + Z^4)); - v4: Y => Z; cytosol*v4_Kf*Y; - v5: Z => EC; extracellular*v5_K*Z; - v6: => A; cytosol*beta*v6_Vp; - v7: A => ; cytosol*v7_Vd*A^2*Z^v7_n/((v7_Kp^2 + A^2)*(v7_Kd^v7_n + Z^v7_n)); - v8: A => ; cytosol*v8_epsilon*A; - - // Species initializations: - EC = 1000; - Z = 0; - A = 0.45; - Y = 0.36; - - // Compartment initializations: - extracellular = 1; - cytosol = 1; - intravesicular = 1; - - // Variable initializations: - beta = 0.5; - vin_v0 = 2; - vin_v1 = 1; - v2_Vm2 = 6.5; - v2_K2 = 0.1; - v3_Vm3 = 19.5; - v3_Ka = 0.2; - v3_Ky = 0.2; - v3_Kz = 0.3; - v4_Kf = 1; - v5_K = 10; - v6_Vp = 2.5; - v7_Vd = 80; - v7_Kp = 1; - v7_Kd = 0.4; - v7_n = 4; - v8_epsilon = 0.1; - - // Other declarations: - const extracellular, cytosol, intravesicular, beta; - - // Unit definitions: - unit substance = 1e-6 mole; - unit time_unit = 60 second; - - // Display Names: - substance is "micromole (default)"; - time_unit is "minute (default)"; - v6 is "Agonist stimulated production of IP3"; - v7 is "Ca dependent IP3 degradation"; - v8 is "Ca independent IP3 degradation"; - - // SBO terms: - extracellular.sboTerm = 290 - cytosol.sboTerm = 290 - intravesicular.sboTerm = 290 - EC.sboTerm = 327 - Z.sboTerm = 327 - A.sboTerm = 327 - Y.sboTerm = 327 - beta.sboTerm = 498 - vin.sboTerm = 185 - vin_v0.sboTerm = 485 - vin_v1.sboTerm = 162 - v2.sboTerm = 185 - v2_Vm2.sboTerm = 186 - v2_K2.sboTerm = 424 - v3.sboTerm = 185 - v3_Vm3.sboTerm = 186 - v3_Ka.sboTerm = 194 - v3_Ky.sboTerm = 424 - v3_Kz.sboTerm = 423 - v4.sboTerm = 185 - v4_Kf.sboTerm = 35 - v5.sboTerm = 185 - v5_K.sboTerm = 35 - v6.sboTerm = 393 - v6_Vp.sboTerm = 48 - v7.sboTerm = 179 - v7_Vd.sboTerm = 324 - v7_Kp.sboTerm = 424 - v7_Kd.sboTerm = 194 - v7_n.sboTerm = 190 - v8.sboTerm = 179 - v8_epsilon.sboTerm = 498 - - // CV terms: - extracellular hypernym "http://identifiers.org/obo.go/GO:0005615" - cytosol hypernym "http://identifiers.org/obo.go/GO:0005829" - intravesicular hypernym "http://identifiers.org/obo.go/GO:0005790" - EC identity "http://identifiers.org/chebi/CHEBI:29108", - "http://identifiers.org/kegg.compound/C00076" - Z identity "http://identifiers.org/chebi/CHEBI:29108", - "http://identifiers.org/kegg.compound/C00076" - A identity "http://identifiers.org/chebi/CHEBI:16595", - "http://identifiers.org/kegg.compound/C01245" - Y identity "http://identifiers.org/chebi/CHEBI:29108", - "http://identifiers.org/kegg.compound/C00076" - vin hypernym "http://identifiers.org/obo.go/GO:0006816", - "http://identifiers.org/obo.go/GO:0007204" - v2 hypernym "http://identifiers.org/obo.go/GO:0051481" - v3 hypernym "http://identifiers.org/obo.go/GO:0006816", - "http://identifiers.org/obo.go/GO:0051482" - v4 hypernym "http://identifiers.org/obo.go/GO:0007204" - v5 hypernym "http://identifiers.org/obo.go/GO:0051481" - v6 hypernym "http://identifiers.org/obo.go/GO:0006021", - "http://identifiers.org/obo.go/GO:0007200" - v7 hypernym "http://identifiers.org/obo.go/GO:0019310" - v8 hypernym "http://identifiers.org/obo.go/GO:0019310" -end - -Goldbeter_Calcium_Oscillation_based_on_CICR_AND_CA_Activated_degradation_of_IP3 is "Borghans1997 - Calcium Oscillation - Model 2" - -Goldbeter_Calcium_Oscillation_based_on_CICR_AND_CA_Activated_degradation_of_IP3 model_entity_is "http://identifiers.org/biomodels.db/MODEL6622948601" -Goldbeter_Calcium_Oscillation_based_on_CICR_AND_CA_Activated_degradation_of_IP3 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000044" -Goldbeter_Calcium_Oscillation_based_on_CICR_AND_CA_Activated_degradation_of_IP3 description "http://identifiers.org/pubmed/17029867" -Goldbeter_Calcium_Oscillation_based_on_CICR_AND_CA_Activated_degradation_of_IP3 hypernym "http://identifiers.org/obo.go/GO:0019722", - "http://identifiers.org/obo.go/GO:0048016" -Goldbeter_Calcium_Oscillation_based_on_CICR_AND_CA_Activated_degradation_of_IP3 parthood "http://identifiers.org/kegg.pathway/rno04020" -Goldbeter_Calcium_Oscillation_based_on_CICR_AND_CA_Activated_degradation_of_IP3 taxon "http://identifiers.org/taxonomy/10114" diff --git a/BioModelsRAG/data/BIOMD0000000045.txt b/BioModelsRAG/data/BIOMD0000000045.txt deleted file mode 100644 index db8d00c66254dd15cee0befebdc7cda34a353163..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000045.txt +++ /dev/null @@ -1,97 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Goldbeter_Calcium_Oscillation_based_onCICR_AND_two_pool_model() - - // Compartments and Species: - compartment extracellular, cytosol, intravesicular1, intravesicular2; - species EC in extracellular, Z in cytosol, Y in intravesicular2, X in intravesicular1; - - // Reactions: - vin: EC => Z; cytosol*(vin_v0 + vin_v1*beta); - v2i: Z => Y; intravesicular2*v2i_Vm2i*Z^2/(v2i_K2i^2 + Z^2); - v3i: Y => Z; cytosol*v3i_Vm3i*Y^2*Z^2/((v3i_K3y^2 + Y^2)*(v3i_K3z^2 + Z^2)); - v4: Y => Z; cytosol*v4_Kf*Y; - v5: Z => EC; extracellular*v5_K*Z; - v6: X => Z; cytosol*v6_Kf*X; - v2s: Z => X; intravesicular1*v2s_Vm2s*Z^2/(v2s_K2s^2 + Z^2); - v3s: X => Z; cytosol*beta*v3s_Vm3s*X^2/(v3s_K3s^2 + X^2); - - // Species initializations: - EC = 0; - Z = 0; - Y = 0; - X = 0.5; - - // Compartment initializations: - extracellular = 1; - cytosol = 1; - intravesicular1 = 1; - intravesicular2 = 1; - - // Variable initializations: - beta = 1; - vin_v0 = 0.015; - vin_v1 = 0.012; - v2i_Vm2i = 3.1; - v2i_K2i = 0.005; - v3i_Vm3i = 25; - v3i_K3y = 0.065; - v3i_K3z = 0.022; - v4_Kf = 0.5; - v5_K = 1; - v6_Kf = 0.5; - v2s_Vm2s = 1.5; - v2s_K2s = 0.0265; - v3s_Vm3s = 0.169; - v3s_K3s = 0.1; - - // Other declarations: - const extracellular, cytosol, intravesicular1, intravesicular2, beta; - - // Unit definitions: - unit substance = 1e-6 mole; - unit time_unit = 60 second; - - // Display Names: - substance is "micromole (default)"; - time_unit is "minute (default)"; - - // CV terms: - extracellular hypernym "http://identifiers.org/obo.go/GO:0005615" - cytosol hypernym "http://identifiers.org/obo.go/GO:0005829" - intravesicular1 hypernym "http://identifiers.org/obo.go/GO:0005790" - EC identity "http://identifiers.org/chebi/CHEBI:29108", - "http://identifiers.org/kegg.compound/C00076" - Z identity "http://identifiers.org/chebi/CHEBI:29108", - "http://identifiers.org/kegg.compound/C00076" - Y identity "http://identifiers.org/chebi/CHEBI:29108", - "http://identifiers.org/kegg.compound/C00076" - X identity "http://identifiers.org/chebi/CHEBI:29108", - "http://identifiers.org/kegg.compound/C00076" - vin hypernym "http://identifiers.org/obo.go/GO:0006816", - "http://identifiers.org/obo.go/GO:0007204" - v2i hypernym "http://identifiers.org/obo.go/GO:0051481", - "http://identifiers.org/obo.go/GO:0006816" - v3i hypernym "http://identifiers.org/obo.go/GO:0005219", - "http://identifiers.org/obo.go/GO:0006816", - "http://identifiers.org/obo.go/GO:0007204" - v4 hypernym "http://identifiers.org/obo.go/GO:0006816", - "http://identifiers.org/obo.go/GO:0007204" - v5 hypernym "http://identifiers.org/obo.go/GO:0051481", - "http://identifiers.org/obo.go/GO:0006816" - v6 hypernym "http://identifiers.org/obo.go/GO:0006816", - "http://identifiers.org/obo.go/GO:0007204" - v2s hypernym "http://identifiers.org/obo.go/GO:0006816", - "http://identifiers.org/obo.go/GO:0051481" - v3s hypernym "http://identifiers.org/obo.go/GO:0006816", - "http://identifiers.org/obo.go/GO:0051482" -end - -Goldbeter_Calcium_Oscillation_based_onCICR_AND_two_pool_model is "Borghans1997 - Calcium Oscillation - Model 3" - -Goldbeter_Calcium_Oscillation_based_onCICR_AND_two_pool_model model_entity_is "http://identifiers.org/biomodels.db/MODEL6623009547" -Goldbeter_Calcium_Oscillation_based_onCICR_AND_two_pool_model model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000045" -Goldbeter_Calcium_Oscillation_based_onCICR_AND_two_pool_model description "http://identifiers.org/pubmed/17029867" -Goldbeter_Calcium_Oscillation_based_onCICR_AND_two_pool_model hypernym "http://identifiers.org/obo.go/GO:0048016", - "http://identifiers.org/obo.go/GO:0019722" -Goldbeter_Calcium_Oscillation_based_onCICR_AND_two_pool_model taxon "http://identifiers.org/taxonomy/10114" -Goldbeter_Calcium_Oscillation_based_onCICR_AND_two_pool_model identity "http://identifiers.org/kegg.pathway/rno04020" diff --git a/BioModelsRAG/data/BIOMD0000000046.txt b/BioModelsRAG/data/BIOMD0000000046.txt deleted file mode 100644 index 616db6882572302b4aef724feae359dd2516aff0..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000046.txt +++ /dev/null @@ -1,127 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Olsen2003_peroxidase() - - // Compartments and Species: - compartment compartment_; - species NADH in compartment_, O2 in compartment_, H2O2 in compartment_; - species per3 in compartment_, coI in compartment_, ArH in compartment_; - species coII in compartment_, Ar in compartment_, NADrad in compartment_; - species super in compartment_, coIII in compartment_, per2 in compartment_; - species $NAD2 in compartment_, $NAD in compartment_, $O2g in compartment_; - species $NADHres in compartment_; - - // Reactions: - v1: NADH + O2 => H2O2 + $NAD; compartment_*v1_k1*NADH*O2; - v2: per3 + H2O2 => coI; compartment_*v2_k2*H2O2*per3; - v3: ArH + coI => Ar + coII; compartment_*v3_k3*coI*ArH; - v4: coII + ArH => per3 + Ar; compartment_*v4_k4*coII*ArH; - v5: NADrad + O2 => $NAD + super; compartment_*v5_k5*NADrad*O2; - v6: per3 + super => coIII; compartment_*v6_k6*super*per3; - v7: 2 super => H2O2 + O2; compartment_*v7_k7*super*super; - v8: NADrad + coIII => $NAD + coI; compartment_*v8_k8*coIII*NADrad; - v9: 2 NADrad => $NAD2; compartment_*v9_k9*NADrad*NADrad; - v10: per3 + NADrad => per2 + $NAD; compartment_*v10_k10*per3*NADrad; - v11: per2 + O2 => coIII; compartment_*v11_k11*per2*O2; - v12: $NADHres => NADH; compartment_*v12_k12; - v131: $O2g => O2; compartment_*v131_k13f*O2g; - v132: O2 => $O2g; compartment_*v132_k13b*O2; - v14: NADH + Ar => NADrad + ArH; compartment_*v14_k14*Ar*NADH; - - // Species initializations: - NADH = 0; - O2 = 0; - H2O2 = 0; - per3 = 1.4; - coI = 0; - ArH = 500; - coII = 0; - Ar = 0; - NADrad = 0; - super = 0; - coIII = 0; - per2 = 0; - NAD2 = 0; - NAD = 0; - O2g = 12; - NADHres = 0; - - // Compartment initializations: - compartment_ = 1; - - // Variable initializations: - v1_k1 = 3e-06; - v2_k2 = 18; - v3_k3 = 0.15; - v4_k4 = 0.0052; - v5_k5 = 20; - v6_k6 = 17; - v7_k7 = 20; - v8_k8 = 40; - v9_k9 = 60; - v10_k10 = 1.8; - v11_k11 = 0.1; - v12_k12 = 0.08; - v131_k13f = 0.006; - v132_k13b = 0.006; - v14_k14 = 0.7; - - // Other declarations: - const compartment_; - - // Unit definitions: - unit substance = 1e-6 mole; - - // Display Names: - substance is "micromole"; - - // CV terms: - NADH identity "http://identifiers.org/chebi/CHEBI:16908", - "http://identifiers.org/kegg.compound/C00004" - O2 identity "http://identifiers.org/chebi/CHEBI:15379", - "http://identifiers.org/kegg.compound/C00007" - H2O2 identity "http://identifiers.org/chebi/CHEBI:16240", - "http://identifiers.org/kegg.compound/C00027" - per3 hypernym "http://identifiers.org/interpro/IPR000823", - "http://identifiers.org/pirsf/PIRSF000293" - coI hypernym "http://identifiers.org/interpro/IPR000823", - "http://identifiers.org/pirsf/PIRSF000293" - ArH version "http://identifiers.org/chebi/CHEBI:30763", - "http://identifiers.org/chebi/CHEBI:16796" - ArH version "http://identifiers.org/kegg.compound/C00156", - "http://identifiers.org/kegg.compound/C01598" - coII hypernym "http://identifiers.org/interpro/IPR000823", - "http://identifiers.org/pirsf/PIRSF000293" - Ar version "http://identifiers.org/chebi/CHEBI:17879", - "http://identifiers.org/chebi/CHEBI:16796" - Ar version "http://identifiers.org/kegg.compound/C00156", - "http://identifiers.org/kegg.compound/C01598" - NADrad hypernym "http://identifiers.org/chebi/CHEBI:15846", - "http://identifiers.org/kegg.compound/C00003" - super identity "http://identifiers.org/chebi/CHEBI:18421", - "http://identifiers.org/kegg.compound/C00704" - coIII hypernym "http://identifiers.org/interpro/IPR000823", - "http://identifiers.org/pirsf/PIRSF000293" - per2 hypernym "http://identifiers.org/interpro/IPR000823", - "http://identifiers.org/pirsf/PIRSF000293" - NAD2 part "http://identifiers.org/chebi/CHEBI:15846" - NAD2 part "http://identifiers.org/kegg.compound/C00003" - NAD identity "http://identifiers.org/chebi/CHEBI:15846", - "http://identifiers.org/kegg.compound/C00003" - O2g identity "http://identifiers.org/chebi/CHEBI:15379", - "http://identifiers.org/kegg.compound/C00007" - NADHres identity "http://identifiers.org/chebi/CHEBI:16908", - "http://identifiers.org/kegg.compound/C00004" - v1 identity "http://identifiers.org/kegg.reaction/R07171" - v1 hypernym "http://identifiers.org/ec-code/1.6.3.1" - v7 identity "http://identifiers.org/kegg.reaction/R00275" - v7 hypernym "http://identifiers.org/ec-code/1.15.1.1" -end - -Olsen2003_peroxidase is "Olsen2003_peroxidase" - -Olsen2003_peroxidase model_entity_is "http://identifiers.org/biomodels.db/MODEL6623265463" -Olsen2003_peroxidase model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000046" -Olsen2003_peroxidase description "http://identifiers.org/pubmed/12823550" -Olsen2003_peroxidase origin "http://identifiers.org/pubmed/11901676" -Olsen2003_peroxidase taxon "http://identifiers.org/taxonomy/3704" -Olsen2003_peroxidase hypernym "http://identifiers.org/go/GO:0016692" diff --git a/BioModelsRAG/data/BIOMD0000000047.txt b/BioModelsRAG/data/BIOMD0000000047.txt deleted file mode 100644 index 07cf65ea7c3f1c16a5eff6c7ae93b91b57af48ac..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000047.txt +++ /dev/null @@ -1,80 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Oxhamre_Bacteria_induced_Ca_oscillations() - - // Compartments and Species: - compartment Cytosol, Endoplasmic_Reticulum; - species CaER in Endoplasmic_Reticulum, Ca_Cyt in Cytosol; - - // Assignment Rules: - n := n0*(exp(-kbN*time) + kappa*(1 - exp(-kbN*time))); - p1 := p11 + p12*n/(K1 + n); - p2 := Ca_Cyt/(K2 + Ca_Cyt); - - // Rate Rules: - p3' = -(k31*Ca_Cyt*p3) + k31*K3*(1 - p3); - - // Reactions: - Jch: CaER => Ca_Cyt; Jch_Fch_0*p1*p2*p3; - Jleak: CaER => Ca_Cyt; Jleak_Fleak; - Jpump: Ca_Cyt => CaER; Jpump_Fpump_0*Ca_Cyt/(Jpump_Kpump + Ca_Cyt); - - // Species initializations: - CaER = 0; - Ca_Cyt = 0; - - // Compartment initializations: - Cytosol = 1; - Endoplasmic_Reticulum = 1; - - // Variable initializations: - n0 = 1; - kbN = 0.5; - kappa = 5; - p11 = 0.2; - p12 = 0.8; - K1 = 5; - K2 = 0.7; - p3 = 0.95; - k31 = 0.5; - K3 = 0.7; - Jch_Fch_0 = 8; - Jleak_Fleak = 0.5; - Jpump_Fpump_0 = 2; - Jpump_Kpump = 0.1; - - // Other declarations: - var n, p1, p2, p3; - const Cytosol, Endoplasmic_Reticulum, n0, kbN, kappa, p11, p12, K1, K2; - const k31, K3; - - // Unit definitions: - unit substance = 1e-6 mole; - unit time_unit = 60 second; - - // Display Names: - substance is "micromole (default)"; - time_unit is "minute (default)"; - - // CV terms: - Cytosol hypernym "http://identifiers.org/go/GO:0005829" - Endoplasmic_Reticulum hypernym "http://identifiers.org/go/GO:0005790" - CaER hypernym "http://identifiers.org/chebi/CHEBI:29108" - Ca_Cyt hypernym "http://identifiers.org/chebi/CHEBI:29108" - Jch hypernym "http://identifiers.org/go/GO:0006816", - "http://identifiers.org/go/GO:0051482" - Jleak hypernym "http://identifiers.org/go/GO:0007204", - "http://identifiers.org/go/GO:0006816" - Jpump hypernym "http://identifiers.org/go/GO:0051481", - "http://identifiers.org/go/GO:0006816" -end - -Oxhamre_Bacteria_induced_Ca_oscillations is "Oxhamre2005_Ca_oscillation" - -Oxhamre_Bacteria_induced_Ca_oscillations model_entity_is "http://identifiers.org/biomodels.db/MODEL6623415355" -Oxhamre_Bacteria_induced_Ca_oscillations model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000047" -Oxhamre_Bacteria_induced_Ca_oscillations description "http://identifiers.org/pubmed/15596518" -Oxhamre_Bacteria_induced_Ca_oscillations origin "http://identifiers.org/pubmed/11874447" -Oxhamre_Bacteria_induced_Ca_oscillations identity "http://identifiers.org/kegg.pathway/rno04020" -Oxhamre_Bacteria_induced_Ca_oscillations taxon "http://identifiers.org/taxonomy/10114" -Oxhamre_Bacteria_induced_Ca_oscillations hypernym "http://identifiers.org/go/GO:0048016", - "http://identifiers.org/go/GO:0019722" diff --git a/BioModelsRAG/data/BIOMD0000000048.txt b/BioModelsRAG/data/BIOMD0000000048.txt deleted file mode 100644 index 9a087375fef45816260c504492e90b2a58073938..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000048.txt +++ /dev/null @@ -1,277 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Kholodenko1999_-_EGFR_signaling() - - // Compartments and Species: - compartment compartment_; - species EGF in compartment_, R in compartment_, Ra in compartment_, R2 in compartment_; - species RP in compartment_, PLCg in compartment_, RPLCg in compartment_; - species RPLCgP in compartment_, PLCgP in compartment_, Grb in compartment_; - species RG in compartment_, SOS in compartment_, RGS in compartment_, GS in compartment_; - species Shc in compartment_, RSh in compartment_, RShP in compartment_; - species ShP in compartment_, RShG in compartment_, ShG in compartment_; - species RShGS in compartment_, ShGS in compartment_, PLCgl in compartment_; - - // Reactions: - v1: R + EGF -> Ra; (v1_k1f*R*EGF - v1_k1b*Ra)*compartment_; - v2: 2 Ra -> R2; (v2_k2f*Ra*Ra - v2_k2b*R2)*compartment_; - v3: R2 -> RP; (v3_k3f*R2 - v3_k3b*RP)*compartment_; - v4: RP => R2; (v4_V4*RP/(v4_K4 + RP))*compartment_; - v5: RP + PLCg -> RPLCg; (v5_k5f*RP*PLCg - v5_k5b*RPLCg)*compartment_; - v6: RPLCg -> RPLCgP; (v6_k6f*RPLCg - v6_k6b*RPLCgP)*compartment_; - v7: RPLCgP -> PLCgP + RP; (v7_k7f*RPLCgP - v7_k7b*RP*PLCgP)*compartment_; - v8: PLCgP => PLCg; (v8_V8*PLCgP/(v8_K8 + PLCgP))*compartment_; - v9: Grb + RP -> RG; (v9_k9f*RP*Grb - v9_k9b*RG)*compartment_; - v10: RG + SOS -> RGS; (v10_k10f*RG*SOS - v10_k10b*RGS)*compartment_; - v11: RGS -> GS + RP; (v11_k11f*RGS - v11_k11b*RP*GS)*compartment_; - v12: GS -> Grb + SOS; (v12_k12f*GS - v12_k12b*Grb*SOS)*compartment_; - v13: Shc + RP -> RSh; (v13_k13f*RP*Shc - v13_k13b*RSh)*compartment_; - v14: RSh -> RShP; (v14_k14f*RSh - v14_k14b*RShP)*compartment_; - v15: RShP -> RP + ShP; (v15_k15f*RShP - v15_k15b*ShP*RP)*compartment_; - v16: ShP => Shc; (v16_V16*ShP/(v16_K16 + ShP))*compartment_; - v17: RShP + Grb -> RShG; (v17_k17f*RShP*Grb - v17_k17b*RShG)*compartment_; - v18: RShG -> ShG + RP; (v18_k18f*RShG - v18_k18b*RP*ShG)*compartment_; - v19: SOS + RShG -> RShGS; (v19_k19f*RShG*SOS - v19_k19b*RShGS)*compartment_; - v20: RShGS -> ShGS + RP; (v20_k20f*RShGS - v20_k20b*ShGS*RP)*compartment_; - v21: Grb + ShP -> ShG; (v21_k21f*ShP*Grb - v21_k21b*ShG)*compartment_; - v22: ShG + SOS -> ShGS; (v22_k22f*ShG*SOS - v22_k22b*ShGS)*compartment_; - v23: ShGS -> GS + ShP; (v23_k23f*ShGS - v23_k23b*ShP*GS)*compartment_; - v24: RShP + GS -> RShGS; (v24_k24f*RShP*GS - v24_k24b*RShGS)*compartment_; - v25: PLCgP -> PLCgl; (v25_k25f*PLCgP - v25_k25b*PLCgl)*compartment_; - - // Species initializations: - EGF = 680; - R = 100; - Ra = 0; - R2 = 0; - RP = 0; - PLCg = 105; - RPLCg = 0; - RPLCgP = 0; - PLCgP = 0; - Grb = 85; - RG = 0; - SOS = 34; - RGS = 0; - GS = 0; - Shc = 150; - RSh = 0; - RShP = 0; - ShP = 0; - RShG = 0; - ShG = 0; - RShGS = 0; - ShGS = 0; - PLCgl = 0; - - // Compartment initializations: - compartment_ = 3e-12; - - // Variable initializations: - v1_k1f = 0.003; - v1_k1b = 0.06; - v2_k2f = 0.01; - v2_k2b = 0.1; - v3_k3f = 1; - v3_k3b = 0.01; - v4_V4 = 450; - v4_K4 = 50; - v5_k5f = 0.06; - v5_k5b = 0.2; - v6_k6f = 1; - v6_k6b = 0.05; - v7_k7f = 0.3; - v7_k7b = 0.006; - v8_V8 = 1; - v8_K8 = 100; - v9_k9f = 0.003; - v9_k9b = 0.05; - v10_k10f = 0.01; - v10_k10b = 0.06; - v11_k11f = 0.03; - v11_k11b = 0.0045; - v12_k12f = 0.0015; - v12_k12b = 0.0001; - v13_k13f = 0.09; - v13_k13b = 0.6; - v14_k14f = 6; - v14_k14b = 0.06; - v15_k15f = 0.3; - v15_k15b = 0.0009; - v16_V16 = 1.7; - v16_K16 = 340; - v17_k17f = 0.003; - v17_k17b = 0.1; - v18_k18f = 0.3; - v18_k18b = 0.0009; - v19_k19f = 0.01; - v19_k19b = 0.0214; - v20_k20f = 0.12; - v20_k20b = 0.00024; - v21_k21f = 0.003; - v21_k21b = 0.1; - v22_k22f = 0.03; - v22_k22b = 0.064; - v23_k23f = 0.1; - v23_k23b = 0.021; - v24_k24f = 0.009; - v24_k24b = 0.0429; - v25_k25f = 1; - v25_k25b = 0.03; - - // Other declarations: - const compartment_; - - // Unit definitions: - unit substance = 1e-9 mole; - - // Display Names: - substance is "nanomole"; - compartment_ is "cytoplasm"; - EGF is "Epidermal_Growth_Factor"; - R is "EGFR"; - Ra is "EGF_EGFR"; - R2 is "(EGF_EGFR)2"; - RP is "(EGF_EGFR)2-P"; - RPLCg is "(EGF_EGFR)2_PLCg"; - RPLCgP is "(EGF_EGFR)2_PLCg-P"; - PLCgP is "PLCg-P"; - Grb is "Grb2"; - RG is "(EGF_EGFR)2_Grb2"; - RGS is "(EGF_EGFR)2_Grb2_SOS"; - GS is "Grb2_SOS"; - RSh is "(EGF_EGFR)2_Shc"; - RShP is "(EGF_EGFR)_Shc-P"; - ShP is "Shc-P"; - RShG is "(EGF_EGFR)2_Shc_Grb2"; - ShG is "Shc_Grb2"; - RShGS is "(EGF_EGFR)2_Shc_Grb2_SOS"; - ShGS is "Shc_Grb2_SOS"; - PLCgl is "PLCgP-I"; - v1 is "EGF_binds_to_EGFR"; - v2 is "association_of_2_Ra_into_dimer"; - v3 is "phosphorylation_of_R2"; - v4 is "dephosphorylation_of_RP"; - v5 is "binding_of_PLCg_to_RP"; - v6 is "phosphorylation_of_PLCg"; - v7 is "dissociation_of_RPLCgP"; - v8 is "dephosphorylation_of_PLCgP"; - v9 is "binding_of_Grb2_to_RP"; - v10 is "binding_of_SOS_to_RG"; - v11 is "dissociation_of_RGS"; - v12 is "dissociation_of_GS"; - v13 is "binding_of_Shc_to_RP"; - v14 is "phosphorylation_of_RSh"; - v15 is "dissociation_of_RShp"; - v16 is "dephosphorylation_of_ShP"; - v17 is "binding_of_Grb2_to_RShP"; - v18 is "dissociation_of_RShG"; - v19 is "binding_of_SOS_to_RShG"; - v20 is "dissociation_of_RShGS"; - v21 is "binding_of_Grb2_to_ShP"; - v22 is "binding_of_SOS_to_ShG"; - v23 is "dissociation_of_ShGS"; - v24 is "association_of_RShP_and_GS"; - v25 is "translocation_of_PLCgP"; - - // CV terms: - compartment_ identity "http://identifiers.org/go/GO:0005737" - EGF identity "http://identifiers.org/uniprot/P07522" - R hypernym "http://identifiers.org/uniprot/Q9QX70" - Ra part "http://identifiers.org/uniprot/Q9QX70", - "http://identifiers.org/uniprot/P07522" - R2 part "http://identifiers.org/uniprot/P07522", - "http://identifiers.org/uniprot/Q9QX70" - RP hypernym "http://identifiers.org/uniprot/Q9QX70" - PLCg hypernym "http://identifiers.org/interpro/IPR001192" - PLCg version "http://identifiers.org/uniprot/P10686", - "http://identifiers.org/uniprot/P24135" - RPLCg version "http://identifiers.org/uniprot/P10686", - "http://identifiers.org/uniprot/P24135", - "http://identifiers.org/uniprot/Q9QX70" - RPLCgP version "http://identifiers.org/uniprot/P24135", - "http://identifiers.org/uniprot/P10686", - "http://identifiers.org/uniprot/Q9QX70" - PLCgP version "http://identifiers.org/interpro/IPR001192" - PLCgP hypernym "http://identifiers.org/uniprot/P24135", - "http://identifiers.org/uniprot/P10686" - Grb identity "http://identifiers.org/uniprot/P62994" - RG part "http://identifiers.org/uniprot/P62994", - "http://identifiers.org/uniprot/Q9QX70" - SOS identity "http://identifiers.org/uniprot/Q9Z1I1" - RGS part "http://identifiers.org/uniprot/Q9QX70", - "http://identifiers.org/uniprot/P62994", - "http://identifiers.org/uniprot/Q9Z1I1" - GS part "http://identifiers.org/uniprot/P62994", - "http://identifiers.org/uniprot/Q9Z1I1" - Shc hypernym "http://identifiers.org/uniprot/Q5M824" - RSh part "http://identifiers.org/uniprot/Q9QX70", - "http://identifiers.org/uniprot/Q5M824" - RShP part "http://identifiers.org/uniprot/Q5M824", - "http://identifiers.org/uniprot/Q9QX70" - ShP hypernym "http://identifiers.org/uniprot/Q5M824" - RShG part "http://identifiers.org/uniprot/Q5M824", - "http://identifiers.org/uniprot/P62994", - "http://identifiers.org/uniprot/Q9QX70" - ShG part "http://identifiers.org/uniprot/Q5M824", - "http://identifiers.org/uniprot/P62994" - RShGS part "http://identifiers.org/uniprot/P62994", - "http://identifiers.org/uniprot/Q5M824", - "http://identifiers.org/uniprot/Q9Z1I1", - "http://identifiers.org/uniprot/Q9QX70" - ShGS part "http://identifiers.org/uniprot/Q5M824", - "http://identifiers.org/uniprot/P62994", - "http://identifiers.org/uniprot/Q9Z1I1" - PLCgl hypernym "http://identifiers.org/interpro/IPR001192" - PLCgl version "http://identifiers.org/uniprot/P24135", - "http://identifiers.org/uniprot/P10686" - v1 identity "http://identifiers.org/go/GO:0005154", - "http://identifiers.org/go/GO:0048408" - v1 parthood "http://identifiers.org/go/GO:0045741" - v2 hypernym "http://identifiers.org/go/GO:0046983" - v3 hypernym "http://identifiers.org/ec-code/2.7.1.37", - "http://identifiers.org/go/GO:0006468", - "http://identifiers.org/go/GO:0004716" - v4 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0006470" - v5 hypernym "http://identifiers.org/go/GO:0051425", - "http://identifiers.org/go/GO:0042169" - v6 hypernym "http://identifiers.org/ec-code/2.7.1.37", - "http://identifiers.org/go/GO:0006468", - "http://identifiers.org/go/GO:0004716" - v8 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0006470" - v9 hypernym "http://identifiers.org/go/GO:0042169", - "http://identifiers.org/go/GO:0051425" - v10 hypernym "http://identifiers.org/go/GO:0005070", - "http://identifiers.org/go/GO:0017124", - "http://identifiers.org/go/GO:0005068" - v13 hypernym "http://identifiers.org/go/GO:0051425", - "http://identifiers.org/go/GO:0042169" - v14 hypernym "http://identifiers.org/ec-code/2.7.1.37", - "http://identifiers.org/go/GO:0006468", - "http://identifiers.org/go/GO:0004716" - v16 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0006470" - v17 hypernym "http://identifiers.org/go/GO:0051425", - "http://identifiers.org/go/GO:0042169" - v19 hypernym "http://identifiers.org/go/GO:0017124", - "http://identifiers.org/go/GO:0005070", - "http://identifiers.org/go/GO:0005068" - v21 hypernym "http://identifiers.org/go/GO:0051425", - "http://identifiers.org/go/GO:0042169" - v22 hypernym "http://identifiers.org/go/GO:0017124", - "http://identifiers.org/go/GO:0005070" - v24 hypernym "http://identifiers.org/go/GO:0051425", - "http://identifiers.org/go/GO:0042169" - v25 hypernym "http://identifiers.org/go/GO:0030845" -end - -Kholodenko1999_-_EGFR_signaling is "Kholodenko1999 - EGFR signaling" - -Kholodenko1999_-_EGFR_signaling model_entity_is "http://identifiers.org/biomodels.db/MODEL6624193277" -Kholodenko1999_-_EGFR_signaling model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000048" -Kholodenko1999_-_EGFR_signaling description "http://identifiers.org/pubmed/10514507" -Kholodenko1999_-_EGFR_signaling model_entity_is "http://identifiers.org/biomodels.db/MODEL6624193277" -Kholodenko1999_-_EGFR_signaling model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000048" -Kholodenko1999_-_EGFR_signaling container "http://identifiers.org/go/GO:0007173" -Kholodenko1999_-_EGFR_signaling taxon "http://identifiers.org/taxonomy/10116" diff --git a/BioModelsRAG/data/BIOMD0000000049.txt b/BioModelsRAG/data/BIOMD0000000049.txt deleted file mode 100644 index 04cfa50ae8f2d36fdbfb470421d713d0f6733363..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000049.txt +++ /dev/null @@ -1,1102 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Sasagawa2005_MAPK() - - // Compartments and Species: - compartment compartment_, c1; - species EGFR in compartment_, L_EGFR in compartment_, L_EGFR_dimer in compartment_; - species SOS in c1, L_dpEGFR in compartment_, pSOS in c1, SOS_Grb2 in c1; - species Grb2 in c1, Dok in c1, pDok in c1, Crk in c1, FRS2 in c1, Shc in c1; - species pSOS_Grb2 in c1, Rap1_GDP in c1, MEK in c1, MKP3 in c1, pShc_dpEGFR in c1; - species dpEGFR_c_Cbl in c1, B_Raf_Rap1_GTP in c1, pShc_dpEGFR_c_Cbl in c1; - species pFRS2_dpEGFR_c_Cbl in c1, Shc_dpEGFR in c1, c_Cbl in c1, RasGAP in c1; - species c_Raf in c1, B_Raf in c1, ERK in c1, PP2A in c1, Ras_GDP in c1; - species Rap1GAP in c1, C3G in c1, NGFR in compartment_, pShc in c1, pFRS2_dpEGFR in c1; - species pTrkA_endo in c1, MEK_ERK in c1, pMEK_ERK in c1, FRS2_dpEGFR_c_Cbl_ubiq in c1; - species Crk_C3G_pFRS2_dpEGFR_c_Cbl in c1, pShc_dpEGFR_c_Cbl_ubiq in c1; - species Crk_C3G_pFRS2_dpEGFR in c1, Grb2_SOS_pShc_dpEGFR_c_Cbl_ubiq in c1; - species Grb2_SOS_pShc_dpEGFR_c_Cbl in c1, Shc_dpEGFR_c_Cbl_ubiq in c1, dpEGFR_c_Cbl_ubiq in c1; - species proteosome in c1, Grb2_SOS_pShc in c1, Shc_dpEGFR_c_Cbl in c1, Grb2_SOS_pShc_dpEGFR in c1; - species pFRS2 in c1, FRS2_dpEGFR in c1, pDok_RasGAP in c1, pMEK in c1, FRS2_dpEGFR_c_Cbl in c1; - species pFRS2_dpEGFR_c_Cbl_ubiq in c1, Ras_GTP in c1, Crk_C3G_pFRS2_dpEGFR_c_Cbl_ubiq in c1; - species c_Raf_Ras_GTP in c1, B_Raf_Ras_GTP in c1, ppMEK in c1, ppERK in c1; - species pTrkA in compartment_, Crk_C3G in c1, Rap1_GTP in c1, L_NGFR in compartment_; - species ppMEK_ERK in c1, dppERK in c1, Shc_pTrkA in c1, Shc_pTrkA_endo in c1; - species pShc_pTrkA in c1, pFRS2_pTrkA in c1, FRS2_pTrkA in c1, pShc_pTrkA_endo in c1; - species FRS2_pTrkA_endo in c1, pFRS2_pTrkA_endo in c1, Crk_C3G_pFRS2_pTrkA_endo in c1; - species Grb2_SOS_pShc_pTrkA in c1, Crk_C3G_pFRS2_pTrkA in c1, Grb2_SOS_pShc_pTrkA_endo in c1; - species c_Raf_Ras_GTP_MEK in c1, c_Raf_Ras_GTP_pMEK in c1, c_Raf_Ras_GTP_MEK_ERK in c1; - species c_Raf_Ras_GTP_pMEK_ERK in c1, B_Raf_Ras_GTP_MEK in c1, B_Raf_Ras_GTP_pMEK in c1; - species B_Raf_Ras_GTP_MEK_ERK in c1, B_Raf_Ras_GTP_pMEK_ERK in c1, B_Raf_Rap1_GTP_MEK in c1; - species B_Raf_Rap1_GTP_pMEK in c1, B_Raf_Rap1_GTP_MEK_ERK in c1, B_Raf_Rap1_GTP_pMEK_ERK in c1; - species ppERK_MKP3 in c1, dppERK_MKP3 in c1, $pro_TrkA in c1, $NGF in compartment_; - species $EGF in compartment_, $pro_EGFR in c1, $degradation in c1; - - // Reactions: - re1: $pro_EGFR -> EGFR; compartment_*(re1_re1_k1*pro_EGFR - re1_re1_k2*EGFR); - re2: $EGF + EGFR -> L_EGFR; compartment_*(re2_re2_k1*EGF*EGFR - re2_re2_k2*L_EGFR); - re8: 2 L_EGFR -> L_EGFR_dimer; compartment_*(re8_re8_k1*L_EGFR*L_EGFR - re8_re8_k2*L_EGFR_dimer); - J3: SOS + Grb2 -> SOS_Grb2; c1*(J3_J3_k1*SOS*Grb2 - J3_J3_k2*SOS_Grb2); - J4: Grb2 + pSOS -> pSOS_Grb2; c1*(J4_J4_k1*Grb2*pSOS - J4_J4_k2*pSOS_Grb2); - J5: L_EGFR_dimer -> L_dpEGFR; compartment_*(J5_J5_k1*L_EGFR_dimer - J5_J5_k2*L_dpEGFR); - J6: L_dpEGFR + c_Cbl -> dpEGFR_c_Cbl; c1*(J6_J6_k1*L_dpEGFR*c_Cbl - J6_J6_k2*dpEGFR_c_Cbl); - J7: L_dpEGFR + pShc -> pShc_dpEGFR; c1*(J7_J7_k1*L_dpEGFR*pShc - J7_J7_k2*pShc_dpEGFR); - J8: pDok -> Dok; c1*(J8_J8_k1*pDok - J8_J8_k2*Dok); - J9: c_Cbl + pShc_dpEGFR -> pShc_dpEGFR_c_Cbl; c1*(J9_J9_k1*c_Cbl*pShc_dpEGFR - J9_J9_k2*pShc_dpEGFR_c_Cbl); - J10: pSOS => SOS; c1*J10_J10_k*pSOS; - J11: pSOS_Grb2 => SOS_Grb2; c1*J11_J11_k*pSOS_Grb2; - J12: L_dpEGFR + Shc -> Shc_dpEGFR; c1*(J12_J12_k1*L_dpEGFR*Shc - J12_J12_k2*Shc_dpEGFR); - J13: Shc_dpEGFR => pShc_dpEGFR; c1*J13_J13_k*Shc_dpEGFR; - J14: dpEGFR_c_Cbl => dpEGFR_c_Cbl_ubiq; c1*J14_J14_k*dpEGFR_c_Cbl; - J15: dpEGFR_c_Cbl_ubiq => proteosome + c_Cbl; c1*J15_J15_k*dpEGFR_c_Cbl_ubiq; - J16: c_Cbl + Shc_dpEGFR -> Shc_dpEGFR_c_Cbl; c1*(J16_J16_k1*c_Cbl*Shc_dpEGFR - J16_J16_k2*Shc_dpEGFR_c_Cbl); - J17: Shc_dpEGFR_c_Cbl => Shc_dpEGFR_c_Cbl_ubiq; c1*J17_J17_k*Shc_dpEGFR_c_Cbl; - J18: Shc_dpEGFR_c_Cbl_ubiq => proteosome + c_Cbl + Shc; c1*J18_J18_k*Shc_dpEGFR_c_Cbl_ubiq; - J19: pShc_dpEGFR_c_Cbl => pShc_dpEGFR_c_Cbl_ubiq; c1*J19_J19_k*pShc_dpEGFR_c_Cbl; - J20: pShc_dpEGFR_c_Cbl_ubiq => proteosome + c_Cbl + pShc; c1*J20_J20_k*pShc_dpEGFR_c_Cbl_ubiq; - J21: Shc_dpEGFR_c_Cbl => pShc_dpEGFR_c_Cbl; c1*J21_J21_k*Shc_dpEGFR_c_Cbl; - J22: pShc + SOS_Grb2 -> Grb2_SOS_pShc; c1*(J22_J22_k1*pShc*SOS_Grb2 - J22_J22_k2*Grb2_SOS_pShc); - J23: L_dpEGFR + Grb2_SOS_pShc -> Grb2_SOS_pShc_dpEGFR; c1*(J23_J23_k1*L_dpEGFR*Grb2_SOS_pShc - J23_J23_k2*Grb2_SOS_pShc_dpEGFR); - J24: pShc_dpEGFR + SOS_Grb2 -> Grb2_SOS_pShc_dpEGFR; c1*(J24_J24_k1*pShc_dpEGFR*SOS_Grb2 - J24_J24_k2*Grb2_SOS_pShc_dpEGFR); - J25: c_Cbl + Grb2_SOS_pShc_dpEGFR -> Grb2_SOS_pShc_dpEGFR_c_Cbl; c1*(J25_J25_k1*c_Cbl*Grb2_SOS_pShc_dpEGFR - J25_J25_k2*Grb2_SOS_pShc_dpEGFR_c_Cbl); - J27: dpEGFR_c_Cbl + Grb2_SOS_pShc -> Grb2_SOS_pShc_dpEGFR_c_Cbl; c1*(J27_J27_k1*dpEGFR_c_Cbl*Grb2_SOS_pShc - J27_J27_k2*Grb2_SOS_pShc_dpEGFR_c_Cbl); - J28: Grb2_SOS_pShc_dpEGFR_c_Cbl => Grb2_SOS_pShc_dpEGFR_c_Cbl_ubiq; c1*J28_J28_k*Grb2_SOS_pShc_dpEGFR_c_Cbl; - J29: Grb2_SOS_pShc_dpEGFR_c_Cbl_ubiq => proteosome + c_Cbl + Grb2_SOS_pShc; c1*J29_J29_k*Grb2_SOS_pShc_dpEGFR_c_Cbl_ubiq; - J30: Grb2_SOS_pShc => Shc + SOS_Grb2; J30_J30_k*Grb2_SOS_pShc; - J31: Dok => pDok; c1*(J31_J31_Vmax*Dok*(L_dpEGFR + Shc_dpEGFR + pShc_dpEGFR + Grb2_SOS_pShc_dpEGFR + dpEGFR_c_Cbl + Shc_dpEGFR_c_Cbl + pShc_dpEGFR_c_Cbl + Grb2_SOS_pShc_dpEGFR_c_Cbl + FRS2_dpEGFR + pFRS2_dpEGFR + Crk_C3G_pFRS2_dpEGFR + FRS2_dpEGFR_c_Cbl + Crk_C3G_pFRS2_dpEGFR_c_Cbl)/(J31_J31_Km1 + Dok)); - J32: pShc => Shc; c1*J32_J32_k*pShc; - J33: pFRS2 => FRS2; c1*J33_J33_k*pFRS2; - J34: Crk + C3G -> Crk_C3G; c1*(J34_J34_k1*Crk*C3G - J34_J34_k2*Crk_C3G); - J35: L_dpEGFR + FRS2 -> FRS2_dpEGFR; c1*(J35_J35_k1*L_dpEGFR*FRS2 - J35_J35_k2*FRS2_dpEGFR); - J36: L_dpEGFR + pFRS2 -> pFRS2_dpEGFR; c1*(J36_J36_k1*L_dpEGFR*pFRS2 - J36_J36_k2*pFRS2_dpEGFR); - J37: FRS2_dpEGFR => pFRS2_dpEGFR; c1*J37_J37_k*FRS2_dpEGFR; - J38: pFRS2_dpEGFR + Crk_C3G -> Crk_C3G_pFRS2_dpEGFR; c1*(J38_J38_k1*pFRS2_dpEGFR*Crk_C3G - J38_J38_k2*Crk_C3G_pFRS2_dpEGFR); - J39: FRS2_dpEGFR + c_Cbl -> FRS2_dpEGFR_c_Cbl; c1*(J39_J39_k1*FRS2_dpEGFR*c_Cbl - J39_J39_k2*FRS2_dpEGFR_c_Cbl); - J40: c_Cbl + pFRS2_dpEGFR -> pFRS2_dpEGFR_c_Cbl; c1*(J40_J40_k1*c_Cbl*pFRS2_dpEGFR - J40_J40_k2*pFRS2_dpEGFR_c_Cbl); - J41: pFRS2_dpEGFR_c_Cbl => pFRS2_dpEGFR_c_Cbl_ubiq; c1*J41_J41_k*pFRS2_dpEGFR_c_Cbl; - J42: FRS2_dpEGFR_c_Cbl => FRS2_dpEGFR_c_Cbl_ubiq; c1*J42_J42_k*FRS2_dpEGFR_c_Cbl; - J43: FRS2_dpEGFR_c_Cbl => pFRS2_dpEGFR_c_Cbl; c1*J43_J43_k*FRS2_dpEGFR_c_Cbl; - J44: pFRS2_dpEGFR_c_Cbl + Crk_C3G -> Crk_C3G_pFRS2_dpEGFR_c_Cbl; c1*(J44_J44_k1*pFRS2_dpEGFR_c_Cbl*Crk_C3G - J44_J44_k2*Crk_C3G_pFRS2_dpEGFR_c_Cbl); - J45: Crk_C3G_pFRS2_dpEGFR_c_Cbl => Crk_C3G_pFRS2_dpEGFR_c_Cbl_ubiq; c1*J45_J45_k*Crk_C3G_pFRS2_dpEGFR_c_Cbl; - J46: FRS2_dpEGFR_c_Cbl_ubiq => proteosome + c_Cbl + FRS2; c1*J46_J46_k*FRS2_dpEGFR_c_Cbl_ubiq; - J47: pFRS2_dpEGFR_c_Cbl_ubiq => proteosome + c_Cbl + pFRS2; c1*J47_J47_k*pFRS2_dpEGFR_c_Cbl_ubiq; - J49: pDok + RasGAP -> pDok_RasGAP; c1*(J49_J49_k1*pDok*RasGAP - J49_J49_k2*pDok_RasGAP); - J50: SOS_Grb2 => pSOS_Grb2; c1*(J50_J50_Vmax*SOS_Grb2*dppERK/(J50_J50_Km1 + SOS_Grb2)); - J51: SOS => pSOS; c1*(J51_J51_Vmax*SOS*dppERK/(J51_J51_Km1 + SOS)); - J52: c_Raf + Ras_GTP -> c_Raf_Ras_GTP; c1*(J52_J52_k1*c_Raf*Ras_GTP - J52_J52_k2*c_Raf_Ras_GTP); - J53: Rap1_GTP + B_Raf -> B_Raf_Rap1_GTP; c1*(J53_J53_k1*Rap1_GTP*B_Raf - J53_J53_k2*B_Raf_Rap1_GTP); - J54: Ras_GTP + B_Raf -> B_Raf_Ras_GTP; c1*(J54_J54_k1*Ras_GTP*B_Raf - J54_J54_k2*B_Raf_Ras_GTP); - J57: ppMEK => pMEK; J57_J57_Vmax*ppMEK*PP2A/(J57_J57_Km1 + ppMEK); - J58: pMEK => MEK; c1*(J58_J58_Vmax*pMEK*PP2A/(J58_J58_Km1 + pMEK)); - J61: ppMEK_ERK => pMEK_ERK; c1*(J61_J61_Vmax*ppMEK_ERK*PP2A/(J61_J61_Km1 + ppMEK_ERK)); - J62: pMEK_ERK => MEK_ERK; c1*(J62_J62_Vmax*pMEK_ERK*PP2A/(J62_J62_Km1 + pMEK_ERK)); - J63: 2 ppERK -> dppERK; c1*(J63_J63_k1*ppERK*ppERK - J63_J63_k2*dppERK); - J66: Ras_GTP => Ras_GDP; c1*J66_J66_k*Ras_GTP; - J67: Rap1_GTP => Rap1_GDP; c1*J67_J67_k*Rap1_GTP; - J68: Rap1_GDP => Rap1_GTP; c1*(J68_J68_Vmax*Rap1_GDP*(Crk_C3G_pFRS2_dpEGFR + Crk_C3G_pFRS2_dpEGFR_c_Cbl + Crk_C3G_pFRS2_pTrkA_endo)/(J68_J68_Km1 + Rap1_GDP)); - J69: Ras_GDP => Ras_GTP; c1*(J69_J69_Vmax*Ras_GDP*(Grb2_SOS_pShc_dpEGFR + Grb2_SOS_pShc_dpEGFR_c_Cbl + Grb2_SOS_pShc_pTrkA)/(J69_J69_Km1 + Ras_GDP)); - J70: $NGF + NGFR -> L_NGFR; compartment_*(J70_J70_k1*NGF*NGFR - J70_J70_k2*L_NGFR); - J71: L_NGFR => pTrkA; compartment_*J71_J71_k*L_NGFR; - J72: pTrkA => pTrkA_endo; c1*J72_J72_k*pTrkA; - J73: pTrkA_endo => $degradation; c1*J73_J73_k*pTrkA_endo; - J74: pTrkA => $degradation; c1*J74_J74_k*pTrkA; - J75: Shc + pTrkA -> Shc_pTrkA; c1*(J75_J75_k1*Shc*pTrkA - J75_J75_k2*Shc_pTrkA); - J76: pShc + pTrkA -> pShc_pTrkA; c1*(J76_J76_k1*pShc*pTrkA - J76_J76_k2*pShc_pTrkA); - J77: FRS2 + pTrkA -> FRS2_pTrkA; c1*(J77_J77_k1*FRS2*pTrkA - J77_J77_k2*FRS2_pTrkA); - J78: pFRS2 + pTrkA -> pFRS2_pTrkA; c1*(J78_J78_k1*pFRS2*pTrkA - J78_J78_k2*pFRS2_pTrkA); - J79: pTrkA_endo + Shc -> Shc_pTrkA_endo; c1*(J79_J79_k1*pTrkA_endo*Shc - J79_J79_k2*Shc_pTrkA_endo); - J80: pTrkA_endo + pShc -> pShc_pTrkA_endo; c1*(J80_J80_k1*pTrkA_endo*pShc - J80_J80_k2*pShc_pTrkA_endo); - J81: Shc_pTrkA_endo => pShc_pTrkA_endo; c1*J81_J81_k*Shc_pTrkA_endo; - J82: Shc_pTrkA => pShc_pTrkA; c1*J82_J82_k*Shc_pTrkA; - J83: FRS2_pTrkA => pFRS2_pTrkA; c1*J83_J83_k*FRS2_pTrkA; - J84: pTrkA_endo + FRS2 -> FRS2_pTrkA_endo; c1*(J84_J84_k1*pTrkA_endo*FRS2 - J84_J84_k2*FRS2_pTrkA_endo); - J85: pTrkA_endo + pFRS2 -> pFRS2_pTrkA_endo; c1*(J85_J85_k1*pTrkA_endo*pFRS2 - J85_J85_k2*pFRS2_pTrkA_endo); - J86: FRS2_pTrkA_endo => pFRS2_pTrkA_endo; c1*J86_J86_k*FRS2_pTrkA_endo; - J87: FRS2_pTrkA => $degradation + FRS2; c1*J87_J87_k*FRS2_pTrkA; - J88: pFRS2_pTrkA => $degradation + pFRS2; c1*J88_J88_k*pFRS2_pTrkA; - J89: Shc_pTrkA => $degradation + Shc; c1*J89_J89_k*Shc_pTrkA; - J90: pShc_pTrkA => $degradation + pShc; c1*J90_J90_k*pShc_pTrkA; - J92: FRS2_pTrkA_endo => $degradation + FRS2; c1*J92_J92_k*FRS2_pTrkA_endo; - J93: Shc_pTrkA_endo => $degradation + Shc; c1*J93_J93_k*Shc_pTrkA_endo; - J94: pShc_pTrkA_endo => $degradation + pShc; c1*J94_J94_k*pShc_pTrkA_endo; - J95: SOS_Grb2 + pShc_pTrkA_endo -> Grb2_SOS_pShc_pTrkA_endo; c1*(J95_J95_k1*SOS_Grb2*pShc_pTrkA_endo - J95_J95_k2*Grb2_SOS_pShc_pTrkA_endo); - J96: SOS_Grb2 + pShc_pTrkA -> Grb2_SOS_pShc_pTrkA; c1*(J96_J96_k1*SOS_Grb2*pShc_pTrkA - J96_J96_k2*Grb2_SOS_pShc_pTrkA); - J97: Grb2_SOS_pShc_pTrkA => Grb2_SOS_pShc_pTrkA_endo; c1*J97_J97_k*Grb2_SOS_pShc_pTrkA; - J98: Crk_C3G_pFRS2_pTrkA => Crk_C3G_pFRS2_pTrkA_endo; c1*J98_J98_k*Crk_C3G_pFRS2_pTrkA; - J99: pFRS2_pTrkA => pFRS2_pTrkA_endo; c1*J99_J99_k*pFRS2_pTrkA; - J100: FRS2_pTrkA => FRS2_pTrkA_endo; c1*J100_J100_k*FRS2_pTrkA; - J101: pShc_pTrkA => pShc_pTrkA_endo; c1*J101_J101_k*pShc_pTrkA; - J102: Shc_pTrkA => Shc_pTrkA_endo; c1*J102_J102_k*Shc_pTrkA; - J103: Crk_C3G + pFRS2_pTrkA -> Crk_C3G_pFRS2_pTrkA; c1*(J103_J103_k1*Crk_C3G*pFRS2_pTrkA - J103_J103_k2*Crk_C3G_pFRS2_pTrkA); - J104: Crk_C3G + pFRS2_pTrkA_endo -> Crk_C3G_pFRS2_pTrkA_endo; c1*(J104_J104_k1*Crk_C3G*pFRS2_pTrkA_endo - J104_J104_k2*Crk_C3G_pFRS2_pTrkA_endo); - J105: Grb2_SOS_pShc + pTrkA -> Grb2_SOS_pShc_pTrkA; c1*(J105_J105_k1*Grb2_SOS_pShc*pTrkA - J105_J105_k2*Grb2_SOS_pShc_pTrkA); - J106: Grb2_SOS_pShc + pTrkA_endo -> Grb2_SOS_pShc_pTrkA_endo; c1*(J106_J106_k1*Grb2_SOS_pShc*pTrkA_endo - J106_J106_k2*Grb2_SOS_pShc_pTrkA_endo); - J107: Crk_C3G_pFRS2_pTrkA => $degradation + pFRS2 + Crk_C3G; c1*J107_J107_k*Crk_C3G_pFRS2_pTrkA; - J108: Crk_C3G_pFRS2_pTrkA_endo => $degradation + Crk_C3G + pFRS2; c1*J108_J108_k*Crk_C3G_pFRS2_pTrkA_endo; - J109: Grb2_SOS_pShc_pTrkA => $degradation + Grb2_SOS_pShc; c1*J109_J109_k*Grb2_SOS_pShc_pTrkA; - J110: Grb2_SOS_pShc_pTrkA_endo => $degradation + Grb2_SOS_pShc; c1*J110_J110_k*Grb2_SOS_pShc_pTrkA_endo; - J112: pFRS2_pTrkA_endo => $degradation + pFRS2; J112_J112_k*pFRS2_pTrkA_endo; - J113: $pro_TrkA -> NGFR; compartment_*(J113_J113_k1*pro_TrkA - J113_J113_k2*NGFR); - J115: Shc + dpEGFR_c_Cbl -> Shc_dpEGFR_c_Cbl; c1*(J115_J115_k1*Shc*dpEGFR_c_Cbl - J115_J115_k2*Shc_dpEGFR_c_Cbl); - J116: dpEGFR_c_Cbl + pShc -> pShc_dpEGFR_c_Cbl; c1*(J116_J116_k1*dpEGFR_c_Cbl*pShc - J116_J116_k2*pShc_dpEGFR_c_Cbl); - J117: pShc_dpEGFR_c_Cbl + SOS_Grb2 -> Grb2_SOS_pShc_dpEGFR_c_Cbl; c1*(J117_J117_k1*pShc_dpEGFR_c_Cbl*SOS_Grb2 - J117_J117_k2*Grb2_SOS_pShc_dpEGFR_c_Cbl); - J119: c_Cbl + Crk_C3G_pFRS2_dpEGFR -> Crk_C3G_pFRS2_dpEGFR_c_Cbl; c1*(J119_J119_k1*c_Cbl*Crk_C3G_pFRS2_dpEGFR - J119_J119_k2*Crk_C3G_pFRS2_dpEGFR_c_Cbl); - J118: dpEGFR_c_Cbl + FRS2 -> FRS2_dpEGFR_c_Cbl; c1*(J118_J118_k1*dpEGFR_c_Cbl*FRS2 - J118_J118_k2*FRS2_dpEGFR_c_Cbl); - J120: dpEGFR_c_Cbl + pFRS2 -> pFRS2_dpEGFR_c_Cbl; c1*(J120_J120_k1*dpEGFR_c_Cbl*pFRS2 - J120_J120_k2*pFRS2_dpEGFR_c_Cbl); - J121: Ras_GTP => Ras_GDP; c1*(J121_J121_Vmax*Ras_GTP*pDok_RasGAP/(J121_J121_Km1 + Ras_GTP)); - J122: Rap1_GTP => Rap1_GDP; c1*(J122_J122_Vmax*Rap1_GTP*Rap1GAP/(J122_J122_Km1 + Rap1_GTP)); - J123: Dok => pDok; c1*(J123_J123_Vmax*Dok*(pTrkA + Shc_pTrkA + pShc_pTrkA + Grb2_SOS_pShc_pTrkA + FRS2_pTrkA + pFRS2_pTrkA + Crk_C3G_pFRS2_pTrkA)/(J123_J123_Km1 + Dok)); - J124: Grb2_SOS_pShc => pShc + pSOS_Grb2; c1*(J124_J124_Vmax*Grb2_SOS_pShc*dppERK/(J124_J124_Km1 + Grb2_SOS_pShc)); - J133: ERK + MEK -> MEK_ERK; c1*(J133_J133_k1*ERK*MEK - J133_J133_k2*MEK_ERK); - J134: ERK + pMEK -> pMEK_ERK; c1*(J134_J134_k1*ERK*pMEK - J134_J134_k2*pMEK_ERK); - J135: ERK + ppMEK -> ppMEK_ERK; c1*(J135_J135_k1*ERK*ppMEK - J135_J135_k2*ppMEK_ERK); - J136: ppMEK_ERK => ppERK + ppMEK; c1*J136_J136_k*ppMEK_ERK; - J137: c_Raf_Ras_GTP => c_Raf + Ras_GDP; c1*(J137_J137_Vmax*c_Raf_Ras_GTP*pDok_RasGAP/(J137_J137_Km1 + c_Raf_Ras_GTP)); - J138: B_Raf_Ras_GTP => B_Raf + Ras_GDP; c1*(J138_J138_Vmax*B_Raf_Ras_GTP*pDok_RasGAP/(J138_J138_Km1 + B_Raf_Ras_GTP)); - J139: B_Raf_Rap1_GTP => B_Raf + Rap1_GDP; c1*(J139_J139_Vmax*B_Raf_Rap1_GTP*Rap1GAP/(J139_J139_Km1 + B_Raf_Rap1_GTP)); - J140: c_Raf_Ras_GTP + MEK => c_Raf_Ras_GTP_MEK; c1*(J140_J140_k1*c_Raf_Ras_GTP*MEK - J140_J140_k2*c_Raf_Ras_GTP_MEK); - J141: c_Raf_Ras_GTP + pMEK -> c_Raf_Ras_GTP_pMEK; c1*(J141_J141_k1*c_Raf_Ras_GTP*pMEK - J141_J141_k2*c_Raf_Ras_GTP_pMEK); - J142: c_Raf_Ras_GTP + MEK_ERK -> c_Raf_Ras_GTP_MEK_ERK; c1*(J142_J142_k1*c_Raf_Ras_GTP*MEK_ERK - J142_J142_k2*c_Raf_Ras_GTP_MEK_ERK); - J143: c_Raf_Ras_GTP + pMEK_ERK -> c_Raf_Ras_GTP_pMEK_ERK; c1*(J143_J143_k1*c_Raf_Ras_GTP*pMEK_ERK - J143_J143_k2*c_Raf_Ras_GTP_pMEK_ERK); - J144: B_Raf_Ras_GTP + MEK -> B_Raf_Ras_GTP_MEK; c1*(J144_J144_k1*B_Raf_Ras_GTP*MEK - J144_J144_k2*B_Raf_Ras_GTP_MEK); - J145: B_Raf_Ras_GTP + pMEK -> B_Raf_Ras_GTP_pMEK; c1*(J145_J145_k1*B_Raf_Ras_GTP*pMEK - J145_J145_k2*B_Raf_Ras_GTP_pMEK); - J146: B_Raf_Ras_GTP + MEK_ERK -> B_Raf_Ras_GTP_MEK_ERK; c1*(J146_J146_k1*B_Raf_Ras_GTP*MEK_ERK - J146_J146_k2*B_Raf_Ras_GTP_MEK_ERK); - J147: B_Raf_Ras_GTP + pMEK_ERK -> B_Raf_Ras_GTP_pMEK_ERK; c1*(J147_J147_k1*B_Raf_Ras_GTP*pMEK_ERK - J147_J147_k2*B_Raf_Ras_GTP_pMEK_ERK); - J148: B_Raf_Rap1_GTP + MEK -> B_Raf_Rap1_GTP_MEK; c1*(J148_J148_k1*B_Raf_Rap1_GTP*MEK - J148_J148_k2*B_Raf_Rap1_GTP_MEK); - J149: B_Raf_Rap1_GTP + pMEK -> B_Raf_Rap1_GTP_pMEK; c1*(J149_J149_k1*B_Raf_Rap1_GTP*pMEK - J149_J149_k2*B_Raf_Rap1_GTP_pMEK); - J150: B_Raf_Rap1_GTP + MEK_ERK -> B_Raf_Rap1_GTP_MEK_ERK; c1*(J150_J150_k1*B_Raf_Rap1_GTP*MEK_ERK - J150_J150_k2*B_Raf_Rap1_GTP_MEK_ERK); - J151: B_Raf_Rap1_GTP + pMEK_ERK -> B_Raf_Rap1_GTP_pMEK_ERK; c1*(J151_J151_k1*B_Raf_Rap1_GTP*pMEK_ERK - J151_J151_k2*B_Raf_Rap1_GTP_pMEK_ERK); - J152: c_Raf_Ras_GTP_MEK => c_Raf_Ras_GTP + pMEK; c1*J152_J152_k*c_Raf_Ras_GTP_MEK; - J153: c_Raf_Ras_GTP_pMEK => c_Raf_Ras_GTP + ppMEK; c1*J153_J153_k*c_Raf_Ras_GTP_pMEK; - J154: c_Raf_Ras_GTP_MEK_ERK => c_Raf_Ras_GTP + pMEK_ERK; c1*J154_J154_k*c_Raf_Ras_GTP_MEK_ERK; - J155: c_Raf_Ras_GTP_pMEK_ERK => c_Raf_Ras_GTP + ppMEK_ERK; c1*J155_J155_k*c_Raf_Ras_GTP_pMEK_ERK; - J156: B_Raf_Ras_GTP_MEK => B_Raf_Ras_GTP + pMEK; c1*J156_J156_k*B_Raf_Ras_GTP_MEK; - J157: B_Raf_Ras_GTP_pMEK => B_Raf_Ras_GTP + ppMEK; c1*J157_J157_k*B_Raf_Ras_GTP_pMEK; - J158: B_Raf_Ras_GTP_MEK_ERK => B_Raf_Ras_GTP + pMEK_ERK; c1*J158_J158_k*B_Raf_Ras_GTP_MEK_ERK; - J159: B_Raf_Ras_GTP_pMEK_ERK => B_Raf_Ras_GTP + ppMEK_ERK; c1*J159_J159_k*B_Raf_Ras_GTP_pMEK_ERK; - J160: B_Raf_Rap1_GTP_MEK => B_Raf_Rap1_GTP + pMEK; c1*J160_J160_k*B_Raf_Rap1_GTP_MEK; - J161: B_Raf_Rap1_GTP_pMEK => B_Raf_Rap1_GTP + ppMEK; c1*J161_J161_k*B_Raf_Rap1_GTP_pMEK; - J162: B_Raf_Rap1_GTP_MEK_ERK => B_Raf_Rap1_GTP + pMEK_ERK; c1*J162_J162_k*B_Raf_Rap1_GTP_MEK_ERK; - J163: B_Raf_Rap1_GTP_pMEK_ERK => B_Raf_Rap1_GTP + ppMEK_ERK; c1*J163_J163_k*B_Raf_Rap1_GTP_pMEK_ERK; - J164: Crk_C3G_pFRS2_dpEGFR_c_Cbl_ubiq => c_Cbl + pFRS2 + Crk_C3G; c1*J164_J164_k*Crk_C3G_pFRS2_dpEGFR_c_Cbl_ubiq; - J165: MKP3 + dppERK => dppERK_MKP3; c1*(J165_J165_k1*MKP3*dppERK - J165_J165_k2*dppERK_MKP3); - J166: MKP3 + ppERK -> ppERK_MKP3; c1*(J166_J166_k1*MKP3*ppERK - J166_J166_k2*ppERK_MKP3); - J167: ppERK_MKP3 => ERK + MKP3; c1*J167_J167_k*ppERK_MKP3; - J168: dppERK_MKP3 => ppERK + ERK + MKP3; c1*J168_J168_k*dppERK_MKP3; - - // Species initializations: - EGFR = 0.3; - L_EGFR = 0; - L_EGFR_dimer = 0; - SOS = 0.1; - L_dpEGFR = 0; - pSOS = 0; - SOS_Grb2 = 0; - Grb2 = 1; - Dok = 0.3; - pDok = 0; - Crk = 1; - FRS2 = 1; - Shc = 1; - pSOS_Grb2 = 0; - Rap1_GDP = 0.2; - MEK = 0.68; - MKP3 = 0.018; - pShc_dpEGFR = 0; - dpEGFR_c_Cbl = 0; - B_Raf_Rap1_GTP = 0; - pShc_dpEGFR_c_Cbl = 0; - pFRS2_dpEGFR_c_Cbl = 0; - Shc_dpEGFR = 0; - c_Cbl = 0.5; - RasGAP = 0.1; - c_Raf = 0.5; - B_Raf = 0.2; - ERK = 0.26; - PP2A = 0.24; - Ras_GDP = 0.1; - Rap1GAP = 0.012; - C3G = 0.5; - NGFR = 0.061894; - pShc = 0; - pFRS2_dpEGFR = 0; - pTrkA_endo = 0; - MEK_ERK = 0; - pMEK_ERK = 0; - FRS2_dpEGFR_c_Cbl_ubiq = 0; - Crk_C3G_pFRS2_dpEGFR_c_Cbl = 0; - pShc_dpEGFR_c_Cbl_ubiq = 0; - Crk_C3G_pFRS2_dpEGFR = 0; - Grb2_SOS_pShc_dpEGFR_c_Cbl_ubiq = 0; - Grb2_SOS_pShc_dpEGFR_c_Cbl = 0; - Shc_dpEGFR_c_Cbl_ubiq = 0; - dpEGFR_c_Cbl_ubiq = 0; - proteosome = 0; - Grb2_SOS_pShc = 0; - Shc_dpEGFR_c_Cbl = 0; - Grb2_SOS_pShc_dpEGFR = 0; - pFRS2 = 0; - FRS2_dpEGFR = 0; - pDok_RasGAP = 0; - pMEK = 0; - FRS2_dpEGFR_c_Cbl = 0; - pFRS2_dpEGFR_c_Cbl_ubiq = 0; - Ras_GTP = 0; - Crk_C3G_pFRS2_dpEGFR_c_Cbl_ubiq = 0; - c_Raf_Ras_GTP = 0; - B_Raf_Ras_GTP = 0; - ppMEK = 0; - ppERK = 0; - pTrkA = 0; - Crk_C3G = 0; - Rap1_GTP = 0; - L_NGFR = 0; - ppMEK_ERK = 0; - dppERK = 0; - Shc_pTrkA = 0; - Shc_pTrkA_endo = 0; - pShc_pTrkA = 0; - pFRS2_pTrkA = 0; - FRS2_pTrkA = 0; - pShc_pTrkA_endo = 0; - FRS2_pTrkA_endo = 0; - pFRS2_pTrkA_endo = 0; - Crk_C3G_pFRS2_pTrkA_endo = 0; - Grb2_SOS_pShc_pTrkA = 0; - Crk_C3G_pFRS2_pTrkA = 0; - Grb2_SOS_pShc_pTrkA_endo = 0; - c_Raf_Ras_GTP_MEK = 0; - c_Raf_Ras_GTP_pMEK = 0; - c_Raf_Ras_GTP_MEK_ERK = 0; - c_Raf_Ras_GTP_pMEK_ERK = 0; - B_Raf_Ras_GTP_MEK = 0; - B_Raf_Ras_GTP_pMEK = 0; - B_Raf_Ras_GTP_MEK_ERK = 0; - B_Raf_Ras_GTP_pMEK_ERK = 0; - B_Raf_Rap1_GTP_MEK = 0; - B_Raf_Rap1_GTP_pMEK = 0; - B_Raf_Rap1_GTP_MEK_ERK = 0; - B_Raf_Rap1_GTP_pMEK_ERK = 0; - ppERK_MKP3 = 0; - dppERK_MKP3 = 0; - pro_TrkA = 0.020631; - NGF = 0; - EGF = 0.001613; - pro_EGFR = 0.3; - degradation = 0; - - // Compartment initializations: - compartment_ = 1; - c1 = 1; - - // Variable initializations: - re1_re1_k1 = 0.0001; - re1_re1_k2 = 0.0001; - re2_re2_k1 = 2.2833; - re2_re2_k2 = 0.0029666; - re8_re8_k1 = 10; - re8_re8_k2 = 0.02; - J3_J3_k1 = 0.03; - J3_J3_k2 = 0.0168; - J4_J4_k1 = 0.03; - J4_J4_k2 = 0.0168; - J5_J5_k1 = 4; - J5_J5_k2 = 0.001; - J6_J6_k1 = 0.5; - J6_J6_k2 = 0.2; - J7_J7_k1 = 10; - J7_J7_k2 = 0.2; - J8_J8_k1 = 0.002; - J8_J8_k2 = 1e-05; - J9_J9_k1 = 0.5; - J9_J9_k2 = 0.2; - J10_J10_k = 0.002; - J11_J11_k = 0.002; - J12_J12_k1 = 10; - J12_J12_k2 = 0.2; - J13_J13_k = 1; - J14_J14_k = 0.05; - J15_J15_k = 0.001; - J16_J16_k1 = 0.5; - J16_J16_k2 = 0.2; - J17_J17_k = 0.05; - J18_J18_k = 0.001; - J19_J19_k = 0.05; - J20_J20_k = 0.001; - J21_J21_k = 1; - J22_J22_k1 = 10; - J22_J22_k2 = 0.2; - J23_J23_k1 = 10; - J23_J23_k2 = 0.2; - J24_J24_k1 = 10; - J24_J24_k2 = 0.2; - J25_J25_k1 = 0.5; - J25_J25_k2 = 0.2; - J27_J27_k1 = 10; - J27_J27_k2 = 0.2; - J28_J28_k = 0.05; - J29_J29_k = 0.001; - J30_J30_k = 0.005; - J31_J31_Vmax = 0.2; - J31_J31_Km1 = 0.1; - J32_J32_k = 0.005; - J33_J33_k = 0.005; - J34_J34_k1 = 1; - J34_J34_k2 = 0.002; - J35_J35_k1 = 1; - J35_J35_k2 = 0.2; - J36_J36_k1 = 1; - J36_J36_k2 = 0.2; - J37_J37_k = 1; - J38_J38_k1 = 1; - J38_J38_k2 = 0.2; - J39_J39_k1 = 0.5; - J39_J39_k2 = 0.2; - J40_J40_k1 = 0.5; - J40_J40_k2 = 0.2; - J41_J41_k = 0.05; - J42_J42_k = 0.05; - J43_J43_k = 1; - J44_J44_k1 = 1; - J44_J44_k2 = 0.2; - J45_J45_k = 0.05; - J46_J46_k = 0.001; - J47_J47_k = 0.001; - J49_J49_k1 = 0.12; - J49_J49_k2 = 0.01; - J50_J50_Vmax = 1; - J50_J50_Km1 = 25.641; - J51_J51_Vmax = 1; - J51_J51_Km1 = 25.641; - J52_J52_k1 = 60; - J52_J52_k2 = 0.5; - J53_J53_k1 = 60; - J53_J53_k2 = 0.5; - J54_J54_k1 = 60; - J54_J54_k2 = 0.5; - J57_J57_Vmax = 3; - J57_J57_Km1 = 15.657; - J58_J58_Vmax = 3; - J58_J58_Km1 = 15.657; - J61_J61_Vmax = 3; - J61_J61_Km1 = 15.657; - J62_J62_Vmax = 3; - J62_J62_Km1 = 15.657; - J63_J63_k1 = 10; - J63_J63_k2 = 0.075; - J66_J66_k = 0.0001667; - J67_J67_k = 0.0001166; - J68_J68_Vmax = 0.024; - J68_J68_Km1 = 0.01; - J69_J69_Vmax = 2; - J69_J69_Km1 = 0.02; - J70_J70_k1 = 6.2; - J70_J70_k2 = 6.4e-05; - J71_J71_k = 1; - J72_J72_k = 0.00063; - J73_J73_k = 0.00042; - J74_J74_k = 0.0022; - J75_J75_k1 = 10; - J75_J75_k2 = 0.2; - J76_J76_k1 = 10; - J76_J76_k2 = 0.2; - J77_J77_k1 = 5; - J77_J77_k2 = 0.1; - J78_J78_k1 = 5; - J78_J78_k2 = 0.1; - J79_J79_k1 = 10; - J79_J79_k2 = 0.2; - J80_J80_k1 = 10; - J80_J80_k2 = 0.2; - J81_J81_k = 0.1; - J82_J82_k = 0.1; - J83_J83_k = 2; - J84_J84_k1 = 5; - J84_J84_k2 = 0.1; - J85_J85_k1 = 5; - J85_J85_k2 = 0.1; - J86_J86_k = 2; - J87_J87_k = 0.0022; - J88_J88_k = 0.0022; - J89_J89_k = 0.0022; - J90_J90_k = 0.0022; - J92_J92_k = 0.00042; - J93_J93_k = 0.00042; - J94_J94_k = 0.00042; - J95_J95_k1 = 10; - J95_J95_k2 = 0.2; - J96_J96_k1 = 10; - J96_J96_k2 = 0.2; - J97_J97_k = 0.00063; - J98_J98_k = 0.00063; - J99_J99_k = 0.00063; - J100_J100_k = 0.00063; - J101_J101_k = 0.00063; - J102_J102_k = 0.00063; - J103_J103_k1 = 1; - J103_J103_k2 = 0.2; - J104_J104_k1 = 1; - J104_J104_k2 = 0.2; - J105_J105_k1 = 10; - J105_J105_k2 = 0.2; - J106_J106_k1 = 10; - J106_J106_k2 = 0.2; - J107_J107_k = 0.0022; - J108_J108_k = 0.00042; - J109_J109_k = 0.0022; - J110_J110_k = 0.00042; - J112_J112_k = 0.00042; - J113_J113_k1 = 0.0008333; - J113_J113_k2 = 0.00027778; - J115_J115_k1 = 10; - J115_J115_k2 = 0.2; - J116_J116_k1 = 10; - J116_J116_k2 = 0.2; - J117_J117_k1 = 10; - J117_J117_k2 = 0.2; - J119_J119_k1 = 0.5; - J119_J119_k2 = 0.2; - J118_J118_k1 = 1; - J118_J118_k2 = 0.2; - J120_J120_k1 = 1; - J120_J120_k2 = 0.2; - J121_J121_Vmax = 10; - J121_J121_Km1 = 1; - J122_J122_Vmax = 2; - J122_J122_Km1 = 1; - J123_J123_Vmax = 0.02; - J123_J123_Km1 = 0.1; - J124_J124_Vmax = 1; - J124_J124_Km1 = 25.641; - J133_J133_k1 = 16.304; - J133_J133_k2 = 0.6; - J134_J134_k1 = 16.304; - J134_J134_k2 = 0.6; - J135_J135_k1 = 16.304; - J135_J135_k2 = 0.6; - J136_J136_k = 0.15; - J137_J137_Vmax = 10; - J137_J137_Km1 = 1; - J138_J138_Vmax = 10; - J138_J138_Km1 = 1; - J139_J139_Vmax = 2; - J139_J139_Km1 = 1; - J140_J140_k1 = 15.625; - J140_J140_k2 = 2; - J141_J141_k1 = 15.625; - J141_J141_k2 = 2; - J142_J142_k1 = 15.625; - J142_J142_k2 = 2; - J143_J143_k1 = 15.625; - J143_J143_k2 = 2; - J144_J144_k1 = 6.25; - J144_J144_k2 = 0.8; - J145_J145_k1 = 6.25; - J145_J145_k2 = 0.8; - J146_J146_k1 = 6.25; - J146_J146_k2 = 0.8; - J147_J147_k1 = 6.25; - J147_J147_k2 = 0.8; - J148_J148_k1 = 9.375; - J148_J148_k2 = 1.2; - J149_J149_k1 = 9.375; - J149_J149_k2 = 1.2; - J150_J150_k1 = 9.375; - J150_J150_k2 = 1.2; - J151_J151_k1 = 9.375; - J151_J151_k2 = 1.2; - J152_J152_k = 0.5; - J153_J153_k = 0.5; - J154_J154_k = 0.5; - J155_J155_k = 0.5; - J156_J156_k = 0.2; - J157_J157_k = 0.2; - J158_J158_k = 0.2; - J159_J159_k = 0.2; - J160_J160_k = 0.3; - J161_J161_k = 0.3; - J162_J162_k = 0.3; - J163_J163_k = 0.3; - J164_J164_k = 0.001; - J165_J165_k1 = 15; - J165_J165_k2 = 0.24; - J166_J166_k1 = 15; - J166_J166_k2 = 0.24; - J167_J167_k = 0.06; - J168_J168_k = 0.06; - - // Other declarations: - const compartment_, c1; - - // Unit definitions: - unit substance = 1e-6 mole; - - // Display Names: - substance is "microMole"; - proteosome is "proteasome"; - re1 is "form_EGFreceptor"; - re2 is "EGFbinding"; - re8 is "dimerization"; - J3 is "binding_SOS_Grb2"; - J4 is "binding_pSOS_Grb2"; - J5 is "EGFRphosphorylation"; - J6 is "binding_cCbI_dpEGFR"; - J7 is "binding_pShc_LdpEGFR"; - J8 is "pDOKdephosphorylation"; - J9 is "binding_cCbl_pShc_dpEGFR"; - J10 is "SOSdephosphorylation"; - J11 is "pSOS_Grb2_dephosphorylation"; - J12 is "binding_Shc_LdpEGFR"; - J13 is "Shc_dpEGFR_phosphorylation"; - J14 is "dpEGFR_c_Cbl_ubiquitination"; - J15 is "dpEGFR_cCbl_degrad"; - J16 is "binding_cCbl_Shc_dpEGFR"; - J17 is "Shc_dpEGFR_c_CBl_Ubiquitination"; - J18 is "Shc_dpEGFR_c_Cbl_ubiq_Degradation"; - J19 is "pShc_dpEGFR_c_Cbl_ubiquitination"; - J20 is "pShc_dpEGFR_c_Cbl_ubiq_degradation"; - J21 is "Shc_dpEGFR_c_Cblphosphorylation"; - J22 is "binding_Grb2_SOS_pShc"; - J23 is "binding_Grb2_SOS_pShc_dpEGFR"; - J24 is "binding_Grb2_SOS_pShc_dpEGFR"; - J25 is "binding_c_Cbl_Grb2_SOS_pShc_dpEGFR"; - J27 is "binding_Grb2_SOS_pShc_to_dpEGFR_c_Cbl"; - J28 is "Grb2_SOS_pShc_dpEGFR_c_Cbl_ubiquitination"; - J29 is "Grb2_SOS_pShc_dpEGFR_c_Cbl_ubiq_degradation"; - J30 is "Grb2_SOS_pShc_Dissociation"; - J32 is "pShc_dephosphorylation"; - J33 is "pFRS2_dephosphorylation"; - J34 is "binding_Crk_to_C3G"; - J35 is "binding_L_dpEGFR_to_FRS2"; - J36 is "binding_pFRS2_to_L_dpEGFR"; - J37 is "FRS2_dpEGFRphsphorylation"; - J38 is "binding_Crk_C3G_to_pFRS2_pRTK"; - J39 is "binding_c_Cbl_to_FRS2_dpEGFR"; - J40 is "binding_c_Cbl_to_pFRS2_dpEGFR"; - J41 is "pFRS2_dpEGFR_c_Cbl_ubiquitiation"; - J42 is "FRS2_dpEGFR_c_Cbl_ubiquitination"; - J43 is "FRS2_dpEGFR_c_Cbl_phosphorylation"; - J44 is "binding_Crk_C3G_to_pFRS2_pFRS2_dpEGFR_c_Cbl"; - J45 is "Crk_C3G_pFRS2_dpEGFR_c_Cbl_ubiquitination"; - J46 is "FRS2_dpEGFR_c_Cbl_ubiq_dissociation"; - J47 is "pFRS2_dpEGFR_c_Cbl_ubiq_dissociation"; - J49 is "binding_RasGAP_to_pDOK"; - J50 is "SOS_Grb2_phosphorylation"; - J51 is "SOS_phosphorylation"; - J52 is "binding_c_Raf_to_Ras_GTP"; - J53 is "binding_B_Raf_to_Rap1_GTP"; - J54 is "binding_B_Raf_to_Ras_GTP"; - J57 is "ppMEK_dephosphorylation"; - J58 is "pMEK_dephosphorylation"; - J61 is "ppMEK_ERK"; - J62 is "pMEK_ERK_dephosphorylation"; - J63 is "ppERK_dimerization"; - J66 is "Ras_GTP_dephosphorylation"; - J67 is "Rap1_GTP_dephosphorylation"; - J68 is "Rap1_GTP_phosphorylation"; - J69 is "Ras_GDP_phosphorylation"; - J70 is "binding_NGF_to_NGFR"; - J71 is "TrkA_phosphorylation"; - J72 is "pTrkA_intermalization"; - J73 is "pTrkA_endo_degradation"; - J74 is "pTrkA_degradation"; - J75 is "binding_Shc_to_pTrkA"; - J76 is "binding_pShc_to_pTrkA"; - J77 is "binding_FRS2_to_pTrkA"; - J78 is "binding_pFRS2_to_pTrkA"; - J79 is "binding_Shc_to_pTrkA_endo"; - J80 is "binding_pShc_to_pTrkA_endo"; - J81 is "Shc_pTrkA_endo_phosphorylation"; - J82 is "Shc_pTrkA_phosphorylation"; - J83 is "pFRS2_pTrkA_phosphorylation"; - J84 is "binding_FRS2_to_pTrkA_endo"; - J85 is "binding_pFRS2_to_pTrkA_endo"; - J86 is "FRS2_pTrkA_endo_phosphorylation"; - J87 is "FRS2_pTrkA_degradation"; - J88 is "pFRS2_pTrkA_degradation"; - J89 is "Shc_pTrkA_degradation"; - J90 is "pShc_pTrkA_degradation"; - J92 is "FRS2_pTrkA_endo_degradation"; - J93 is "Shc_pTrkA_endo_degradation"; - J94 is "pShc_pTrkA_endo_degradation"; - J95 is "binding_Grb2_SOS_to_pShc_pTrkA_endo"; - J96 is "binding_Grb2_SOS_to_pShc_pTrkA"; - J97 is "Grb2_SOS_pShc_pTrkA_ubiquitination"; - J98 is "Crk_C3G_pFRS2_pTrkA_ubiquitination"; - J99 is "pFRS2_pTrkA_ubiquitination"; - J100 is "FRS2_pTrkA_ubiquitination"; - J101 is "pShc_pTrkA_ubiquitination"; - J102 is "Shc_pTrkA_ubiquitination"; - J103 is "binding_Crk_C3G_to_pFRS2_pTrkA"; - J104 is "binding_Crk_C3G_to_pFRS2_pTrkA_endo"; - J105 is "binding_Grb2_SOS_pShc_to_pTrkA"; - J106 is "binding_Grb2_SOS_pShc_to_pTrkA_endo"; - J107 is "Crk_C3G_pFRS2_pTrkA_degradation"; - J108 is "Crk_C3G_pFRS2_pTrkA_endo_degradation"; - J109 is "Grb2_SOS_pShc_pTrkA_degradation"; - J110 is "Grb2_SOS_pShc_pTrkA_endo_degradation"; - J112 is "pFRS2_pTrkA_endo_degradation"; - J113 is "form_NGFreceptor"; - J115 is "binding_Shc_to_dpEGFR_c_Cbl"; - J116 is "binding_pShc_to_dpEGFR_c_Cbl"; - J117 is "binding_SOS_Grb2_to_pShc_dpEGFR_c_Cbl"; - J119 is "binding_c_Cbl_to_Crk_C3G_pFRS2_dpEGFR"; - J118 is "binding_FRS2_to_dpEGFR_c_Cbl"; - J120 is "binding_pFRS2_to_dpEGFR_c_Cbl"; - J121 is "Ras_GTP_dephosphorylation"; - J122 is "RAP1_GTP_dephosphorylation"; - J123 is "Dok_phosphorylation"; - J124 is "Grb1_SOS_pShc_dissociation"; - J133 is "binding_MEK_to_ERK"; - J134 is "binding_ERK_to_pMEK"; - J135 is "binding_ERK_to_ppMEK"; - J136 is "ppMEK_ERK_dissociation"; - J137 is "c_Raf_Ras_GTP_dissociation"; - J138 is "B_Raf_Ras_GTP_dissociation"; - J139 is "B_Raf_Rap1_GTP_dissociation"; - - // CV terms: - compartment_ hypernym "http://identifiers.org/go/GO:0009898" - c1 hypernym "http://identifiers.org/go/GO:0005737" - EGFR parthood "http://identifiers.org/uniprot/Q9QX70" - L_EGFR part "http://identifiers.org/uniprot/P07522", - "http://identifiers.org/uniprot/Q9QX70" - L_EGFR_dimer part "http://identifiers.org/uniprot/P07522", - "http://identifiers.org/uniprot/Q9QX70" - SOS hypernym "http://identifiers.org/uniprot/Q9Z1I1" - L_dpEGFR part "http://identifiers.org/uniprot/Q9QX70", - "http://identifiers.org/uniprot/P07522" - pSOS hypernym "http://identifiers.org/uniprot/Q9Z1I1" - SOS_Grb2 part "http://identifiers.org/uniprot/Q9Z1I1", - "http://identifiers.org/uniprot/P62994" - Grb2 identity "http://identifiers.org/uniprot/P62994" - Dok hypernym "http://identifiers.org/uniprot/Q4QQV2", - "http://identifiers.org/interpro/IPR002404" - pDok hypernym "http://identifiers.org/uniprot/Q4QQV2", - "http://identifiers.org/interpro/IPR002404" - pDok hypernym "http://identifiers.org/kegg.compound/C00562" - Crk identity "http://identifiers.org/uniprot/Q63768" - FRS2 hypernym "http://identifiers.org/uniprot/D4A244" - Shc hypernym "http://identifiers.org/uniprot/Q5M824" - pSOS_Grb2 part "http://identifiers.org/uniprot/Q9Z1I1", - "http://identifiers.org/uniprot/P62994" - Rap1_GDP part "http://identifiers.org/chebi/CHEBI:17552", - "http://identifiers.org/uniprot/Q62636" - MEK version "http://identifiers.org/uniprot/Q01986" - MKP3 identity "http://identifiers.org/uniprot/Q64346" - pShc_dpEGFR part "http://identifiers.org/uniprot/P07522", - "http://identifiers.org/uniprot/Q5M824", - "http://identifiers.org/uniprot/Q9QX70" - dpEGFR_c_Cbl part "http://identifiers.org/uniprot/Q8K4S7", - "http://identifiers.org/uniprot/Q9QX70" - B_Raf_Rap1_GTP part "http://identifiers.org/chebi/CHEBI:15996", - "http://identifiers.org/uniprot/Q62636", - "http://identifiers.org/uniprot/Q99MC6" - pShc_dpEGFR_c_Cbl part "http://identifiers.org/uniprot/Q8K4S7", - "http://identifiers.org/uniprot/Q5M824", - "http://identifiers.org/uniprot/Q9QX70" - pFRS2_dpEGFR_c_Cbl part "http://identifiers.org/uniprot/Q9QX70", - "http://identifiers.org/uniprot/D4A244", - "http://identifiers.org/uniprot/Q8K4S7" - Shc_dpEGFR part "http://identifiers.org/uniprot/Q5M824", - "http://identifiers.org/uniprot/P07522", - "http://identifiers.org/uniprot/Q9QX70" - c_Cbl homolog "http://identifiers.org/uniprot/Q8K4S7" - RasGAP identity "http://identifiers.org/interpro/IPR011575" - c_Raf identity "http://identifiers.org/uniprot/P11345" - B_Raf identity "http://identifiers.org/uniprot/Q99MC6" - ERK identity "http://identifiers.org/uniprot/P63086" - PP2A version "http://identifiers.org/uniprot/P62716", - "http://identifiers.org/uniprot/P63331" - Ras_GDP part "http://identifiers.org/chebi/CHEBI:17552", - "http://identifiers.org/interpro/IPR003577" - Rap1GAP version "http://identifiers.org/uniprot/P47736" - C3G identity "http://identifiers.org/uniprot/Q9QYV3" - NGFR identity "http://identifiers.org/uniprot/P35739" - pShc hypernym "http://identifiers.org/uniprot/Q5M824" - pFRS2_dpEGFR part "http://identifiers.org/uniprot/Q8C180", - "http://identifiers.org/uniprot/P07522", - "http://identifiers.org/uniprot/Q9QX70" - pTrkA_endo hypernym "http://identifiers.org/uniprot/P35739" - MEK_ERK part "http://identifiers.org/uniprot/P63086", - "http://identifiers.org/uniprot/Q01986" - pMEK_ERK part "http://identifiers.org/uniprot/P63086", - "http://identifiers.org/uniprot/Q01986" - FRS2_dpEGFR_c_Cbl_ubiq part "http://identifiers.org/uniprot/Q9QX70", - "http://identifiers.org/uniprot/D4A244", - "http://identifiers.org/uniprot/Q8K4S7" - Crk_C3G_pFRS2_dpEGFR_c_Cbl part "http://identifiers.org/uniprot/Q9QYV3", - "http://identifiers.org/uniprot/Q9QX70", - "http://identifiers.org/uniprot/Q63768", - "http://identifiers.org/uniprot/D4A244", - "http://identifiers.org/uniprot/Q8K4S7" - pShc_dpEGFR_c_Cbl_ubiq part "http://identifiers.org/uniprot/Q9QX70", - "http://identifiers.org/uniprot/Q5M824", - "http://identifiers.org/uniprot/Q8K4S7" - Crk_C3G_pFRS2_dpEGFR part "http://identifiers.org/uniprot/Q9QX70", - "http://identifiers.org/uniprot/Q9QYV3", - "http://identifiers.org/uniprot/Q63768", - "http://identifiers.org/uniprot/D4A244" - Grb2_SOS_pShc_dpEGFR_c_Cbl_ubiq part "http://identifiers.org/uniprot/Q8K4S7", - "http://identifiers.org/uniprot/Q9QX70", - "http://identifiers.org/uniprot/Q5M824", - "http://identifiers.org/uniprot/P62994", - "http://identifiers.org/uniprot/Q9Z1I1" - Grb2_SOS_pShc_dpEGFR_c_Cbl part "http://identifiers.org/uniprot/Q8K4S7", - "http://identifiers.org/uniprot/Q9QX70", - "http://identifiers.org/uniprot/Q5M824", - "http://identifiers.org/uniprot/P62994", - "http://identifiers.org/uniprot/Q9Z1I1" - Shc_dpEGFR_c_Cbl_ubiq part "http://identifiers.org/uniprot/Q8K4S7", - "http://identifiers.org/uniprot/Q9QX70", - "http://identifiers.org/uniprot/Q5M824" - dpEGFR_c_Cbl_ubiq part "http://identifiers.org/uniprot/Q8K4S7", - "http://identifiers.org/uniprot/Q9QX70" - proteosome hypernym "http://identifiers.org/go/GO:0000502" - Grb2_SOS_pShc part "http://identifiers.org/uniprot/P62994", - "http://identifiers.org/uniprot/Q5M824", - "http://identifiers.org/uniprot/Q9Z1I1" - Shc_dpEGFR_c_Cbl part "http://identifiers.org/uniprot/Q5M824", - "http://identifiers.org/uniprot/Q8K4S7", - "http://identifiers.org/uniprot/Q9QX70" - Grb2_SOS_pShc_dpEGFR part "http://identifiers.org/uniprot/Q9QX70", - "http://identifiers.org/uniprot/Q9Z1I1", - "http://identifiers.org/uniprot/Q5M824", - "http://identifiers.org/uniprot/P62994" - pFRS2 hypernym "http://identifiers.org/uniprot/D4A244", - "http://identifiers.org/kegg.compound/C00562" - FRS2_dpEGFR part "http://identifiers.org/uniprot/Q9QX70", - "http://identifiers.org/uniprot/D4A244" - pDok_RasGAP part "http://identifiers.org/uniprot/Q4QQV2", - "http://identifiers.org/interpro/IPR011575" - pMEK hypernym "http://identifiers.org/uniprot/Q01986" - FRS2_dpEGFR_c_Cbl part "http://identifiers.org/uniprot/Q9QX70", - "http://identifiers.org/uniprot/D4A244", - "http://identifiers.org/uniprot/Q8K4S7" - pFRS2_dpEGFR_c_Cbl_ubiq part "http://identifiers.org/uniprot/D4A244", - "http://identifiers.org/uniprot/Q8K4S7", - "http://identifiers.org/uniprot/Q9QX70" - Ras_GTP identity "http://identifiers.org/interpro/IPR003577" - Crk_C3G_pFRS2_dpEGFR_c_Cbl_ubiq part "http://identifiers.org/uniprot/D4A244", - "http://identifiers.org/uniprot/Q9QX70", - "http://identifiers.org/uniprot/Q9QYV3", - "http://identifiers.org/uniprot/Q63768", - "http://identifiers.org/uniprot/Q8K4S7" - c_Raf_Ras_GTP part "http://identifiers.org/uniprot/P11345", - "http://identifiers.org/interpro/IPR003577" - B_Raf_Ras_GTP part "http://identifiers.org/uniprot/P28028", - "http://identifiers.org/interpro/IPR003577" - ppMEK hypernym "http://identifiers.org/uniprot/Q01986" - ppERK hypernym "http://identifiers.org/uniprot/P63086" - pTrkA hypernym "http://identifiers.org/uniprot/P35739" - Crk_C3G part "http://identifiers.org/uniprot/Q63768", - "http://identifiers.org/uniprot/Q9QYV3" - Rap1_GTP hypernym "http://identifiers.org/uniprot/Q62636" - L_NGFR part "http://identifiers.org/uniprot/P35739", - "http://identifiers.org/uniprot/P25427" - ppMEK_ERK part "http://identifiers.org/uniprot/Q01986", - "http://identifiers.org/uniprot/P63086" - dppERK hypernym "http://identifiers.org/uniprot/P63086" - Shc_pTrkA part "http://identifiers.org/uniprot/P35739", - "http://identifiers.org/uniprot/Q5M824" - Shc_pTrkA_endo part "http://identifiers.org/uniprot/P35739", - "http://identifiers.org/uniprot/Q5M824" - pShc_pTrkA part "http://identifiers.org/uniprot/P35739", - "http://identifiers.org/uniprot/Q5M824" - pFRS2_pTrkA part "http://identifiers.org/uniprot/P35739", - "http://identifiers.org/uniprot/D4A244" - FRS2_pTrkA part "http://identifiers.org/uniprot/D4A244", - "http://identifiers.org/uniprot/P35739" - pShc_pTrkA_endo part "http://identifiers.org/uniprot/Q5M824", - "http://identifiers.org/uniprot/P35739" - FRS2_pTrkA_endo part "http://identifiers.org/uniprot/D4A244", - "http://identifiers.org/uniprot/P35739" - pFRS2_pTrkA_endo part "http://identifiers.org/uniprot/P35739", - "http://identifiers.org/uniprot/D4A244" - Crk_C3G_pFRS2_pTrkA_endo part "http://identifiers.org/uniprot/P35739", - "http://identifiers.org/uniprot/Q9QYV3", - "http://identifiers.org/uniprot/Q63768", - "http://identifiers.org/uniprot/D4A244" - Grb2_SOS_pShc_pTrkA part "http://identifiers.org/uniprot/Q5M824", - "http://identifiers.org/uniprot/Q9Z1I1", - "http://identifiers.org/uniprot/P62994", - "http://identifiers.org/uniprot/P35739" - Crk_C3G_pFRS2_pTrkA part "http://identifiers.org/uniprot/P35739", - "http://identifiers.org/uniprot/Q9QYV3", - "http://identifiers.org/uniprot/Q63768", - "http://identifiers.org/uniprot/D4A244" - Grb2_SOS_pShc_pTrkA_endo part "http://identifiers.org/uniprot/Q9Z1I1", - "http://identifiers.org/uniprot/P35739", - "http://identifiers.org/uniprot/Q5M824", - "http://identifiers.org/uniprot/P62994" - c_Raf_Ras_GTP_MEK part "http://identifiers.org/uniprot/Q01986", - "http://identifiers.org/uniprot/P11345", - "http://identifiers.org/interpro/IPR003577" - c_Raf_Ras_GTP_pMEK part "http://identifiers.org/uniprot/P11345", - "http://identifiers.org/uniprot/P36506", - "http://identifiers.org/interpro/IPR003577" - c_Raf_Ras_GTP_MEK_ERK part "http://identifiers.org/uniprot/P63086", - "http://identifiers.org/uniprot/P11345", - "http://identifiers.org/uniprot/Q01986", - "http://identifiers.org/interpro/IPR003577" - c_Raf_Ras_GTP_pMEK_ERK part "http://identifiers.org/uniprot/P63086", - "http://identifiers.org/uniprot/Q01986", - "http://identifiers.org/uniprot/P11345", - "http://identifiers.org/interpro/IPR003577" - B_Raf_Ras_GTP_MEK part "http://identifiers.org/uniprot/Q01986", - "http://identifiers.org/uniprot/Q99MC6", - "http://identifiers.org/interpro/IPR003577" - B_Raf_Ras_GTP_pMEK part "http://identifiers.org/uniprot/Q01986", - "http://identifiers.org/uniprot/Q99MC6", - "http://identifiers.org/interpro/IPR003577" - B_Raf_Ras_GTP_MEK_ERK part "http://identifiers.org/uniprot/P63086", - "http://identifiers.org/uniprot/Q01986", - "http://identifiers.org/uniprot/Q99MC6", - "http://identifiers.org/interpro/IPR003577" - B_Raf_Ras_GTP_pMEK_ERK part "http://identifiers.org/uniprot/Q01986", - "http://identifiers.org/uniprot/P63086", - "http://identifiers.org/uniprot/Q99MC6", - "http://identifiers.org/interpro/IPR003577" - B_Raf_Rap1_GTP_MEK part "http://identifiers.org/chebi/CHEBI:15996", - "http://identifiers.org/uniprot/Q01986", - "http://identifiers.org/uniprot/Q99MC6", - "http://identifiers.org/uniprot/Q62636" - B_Raf_Rap1_GTP_pMEK part "http://identifiers.org/chebi/CHEBI:15996", - "http://identifiers.org/uniprot/Q01986", - "http://identifiers.org/uniprot/Q62636", - "http://identifiers.org/uniprot/Q99MC6" - B_Raf_Rap1_GTP_MEK_ERK part "http://identifiers.org/chebi/CHEBI:15996", - "http://identifiers.org/uniprot/P63086", - "http://identifiers.org/uniprot/Q01986", - "http://identifiers.org/uniprot/Q62636", - "http://identifiers.org/uniprot/Q99MC6" - B_Raf_Rap1_GTP_pMEK_ERK part "http://identifiers.org/chebi/CHEBI:15996", - "http://identifiers.org/uniprot/P63086", - "http://identifiers.org/uniprot/Q01986", - "http://identifiers.org/uniprot/Q62636", - "http://identifiers.org/uniprot/Q99MC6" - ppERK_MKP3 part "http://identifiers.org/uniprot/Q64346", - "http://identifiers.org/uniprot/P63086" - dppERK_MKP3 part "http://identifiers.org/uniprot/Q64346", - "http://identifiers.org/uniprot/Q01986" - pro_TrkA hypernym "http://identifiers.org/uniprot/P35739" - NGF identity "http://identifiers.org/uniprot/P25427" - EGF identity "http://identifiers.org/uniprot/P07522" - pro_EGFR hypernym "http://identifiers.org/uniprot/Q9QX70" - re1 parthood "http://identifiers.org/go/GO:0045741" - re2 parthood "http://identifiers.org/go/GO:0045741" - re2 identity "http://identifiers.org/go/GO:0005154", - "http://identifiers.org/go/GO:0048408" - re8 hypernym "http://identifiers.org/go/GO:0005154" - J3 hypernym "http://identifiers.org/go/GO:0005068", - "http://identifiers.org/go/GO:0005070", - "http://identifiers.org/go/GO:0017124" - J4 hypernym "http://identifiers.org/go/GO:0017124", - "http://identifiers.org/go/GO:0005070", - "http://identifiers.org/go/GO:0005068" - J5 hypernym "http://identifiers.org/go/GO:0004716" - J6 hypernym "http://identifiers.org/go/GO:0051425" - J7 hypernym "http://identifiers.org/go/GO:0051425", - "http://identifiers.org/go/GO:0042169" - J8 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0006470" - J9 identity "http://identifiers.org/go/GO:0031625", - "http://identifiers.org/go/GO:0017124" - J10 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0006470" - J11 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0006470" - J12 hypernym "http://identifiers.org/go/GO:0042169" - J13 hypernym "http://identifiers.org/go/GO:0006468", - "http://identifiers.org/go/GO:0004716" - J14 hypernym "http://identifiers.org/go/GO:0016567" - J15 identity "http://identifiers.org/go/GO:0043161" - J16 identity "http://identifiers.org/go/GO:0031625", - "http://identifiers.org/go/GO:0017124" - J17 hypernym "http://identifiers.org/go/GO:0016567" - J18 identity "http://identifiers.org/go/GO:0043161" - J19 hypernym "http://identifiers.org/go/GO:0016567" - J20 identity "http://identifiers.org/go/GO:0043161" - J21 hypernym "http://identifiers.org/go/GO:0004716", - "http://identifiers.org/go/GO:0006468" - J22 hypernym "http://identifiers.org/go/GO:0005070" - J23 hypernym "http://identifiers.org/go/GO:0042169" - J24 hypernym "http://identifiers.org/go/GO:0005070" - J25 identity "http://identifiers.org/go/GO:0031625", - "http://identifiers.org/go/GO:0017124" - J27 hypernym "http://identifiers.org/go/GO:0042169" - J28 hypernym "http://identifiers.org/go/GO:0016567" - J29 identity "http://identifiers.org/go/GO:0043161" - J30 hypernym "http://identifiers.org/go/GO:0043241" - J31 hypernym "http://identifiers.org/go/GO:0006468", - "http://identifiers.org/go/GO:0004716" - J32 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0006470" - J33 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0006470" - J34 hypernym "http://identifiers.org/go/GO:0006461" - J35 identity "http://identifiers.org/go/GO:0051425" - J36 identity "http://identifiers.org/go/GO:0051425" - J37 hypernym "http://identifiers.org/go/GO:0004716" - J38 hypernym "http://identifiers.org/go/GO:0042169" - J39 hypernym "http://identifiers.org/go/GO:0031625" - J40 hypernym "http://identifiers.org/go/GO:0031625" - J41 hypernym "http://identifiers.org/go/GO:0016567" - J42 hypernym "http://identifiers.org/go/GO:0016567" - J43 hypernym "http://identifiers.org/go/GO:0004716", - "http://identifiers.org/go/GO:0006468" - J44 hypernym "http://identifiers.org/go/GO:0042169" - J45 hypernym "http://identifiers.org/go/GO:0016567" - J46 hypernym "http://identifiers.org/go/GO:0043161" - J47 hypernym "http://identifiers.org/go/GO:0043161" - J49 parthood "http://identifiers.org/go/GO:0046580" - J50 hypernym "http://identifiers.org/go/GO:0006468" - J51 hypernym "http://identifiers.org/go/GO:0006468" - J52 hypernym "http://identifiers.org/go/GO:0000185" - J53 hypernym "http://identifiers.org/go/GO:0000185" - J54 hypernym "http://identifiers.org/go/GO:0000185" - J57 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0006470" - J57 parthood "http://identifiers.org/go/GO:0051389" - J58 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0006470" - J58 parthood "http://identifiers.org/go/GO:0051389" - J61 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0006470" - J61 parthood "http://identifiers.org/go/GO:0051389" - J62 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0006470" - J62 parthood "http://identifiers.org/go/GO:0051389" - J63 hypernym "http://identifiers.org/go/GO:0005154" - J66 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0006470" - J66 parthood "http://identifiers.org/go/GO:0046580" - J67 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0006470" - J68 hypernym "http://identifiers.org/go/GO:0005085", - "http://identifiers.org/go/GO:0006468" - J69 hypernym "http://identifiers.org/go/GO:0006468", - "http://identifiers.org/go/GO:0005085" - J70 hypernym "http://identifiers.org/go/GO:0048406", - "http://identifiers.org/go/GO:0051396" - J71 hypernym "http://identifiers.org/go/GO:0004716", - "http://identifiers.org/go/GO:0006468" - J72 hypernym "http://identifiers.org/go/GO:0031623" - J73 hypernym "http://identifiers.org/go/GO:0043241" - J74 hypernym "http://identifiers.org/go/GO:0043241" - J75 hypernym "http://identifiers.org/go/GO:0042169", - "http://identifiers.org/go/GO:0051425" - J76 hypernym "http://identifiers.org/go/GO:0051425", - "http://identifiers.org/go/GO:0042169" - J77 hypernym "http://identifiers.org/go/GO:0051425" - J78 hypernym "http://identifiers.org/go/GO:0051425" - J79 hypernym "http://identifiers.org/go/GO:0051425", - "http://identifiers.org/go/GO:0042169" - J80 hypernym "http://identifiers.org/go/GO:0042169", - "http://identifiers.org/go/GO:0051425" - J81 hypernym "http://identifiers.org/go/GO:0006468" - J82 hypernym "http://identifiers.org/go/GO:0006468" - J83 hypernym "http://identifiers.org/go/GO:0006468" - J84 hypernym "http://identifiers.org/go/GO:0051425" - J85 hypernym "http://identifiers.org/go/GO:0051425" - J86 hypernym "http://identifiers.org/go/GO:0006468" - J87 hypernym "http://identifiers.org/go/GO:0043241" - J88 hypernym "http://identifiers.org/go/GO:0043241" - J89 hypernym "http://identifiers.org/go/GO:0043241" - J90 hypernym "http://identifiers.org/go/GO:0043241" - J92 hypernym "http://identifiers.org/go/GO:0043241" - J93 hypernym "http://identifiers.org/go/GO:0043241" - J94 hypernym "http://identifiers.org/go/GO:0043241" - J95 hypernym "http://identifiers.org/go/GO:0005070" - J96 hypernym "http://identifiers.org/go/GO:0005070" - J97 hypernym "http://identifiers.org/go/GO:0016567" - J98 hypernym "http://identifiers.org/go/GO:0016567" - J99 hypernym "http://identifiers.org/go/GO:0016567" - J100 hypernym "http://identifiers.org/go/GO:0016567" - J101 hypernym "http://identifiers.org/go/GO:0016567" - J102 hypernym "http://identifiers.org/go/GO:0016567" - J103 hypernym "http://identifiers.org/go/GO:0042169" - J104 hypernym "http://identifiers.org/go/GO:0042169" - J105 hypernym "http://identifiers.org/go/GO:0051425", - "http://identifiers.org/go/GO:0042169" - J106 hypernym "http://identifiers.org/go/GO:0051425", - "http://identifiers.org/go/GO:0042169" - J107 hypernym "http://identifiers.org/go/GO:0043241" - J108 hypernym "http://identifiers.org/go/GO:0043241" - J109 hypernym "http://identifiers.org/go/GO:0043241" - J110 hypernym "http://identifiers.org/go/GO:0043241" - J112 hypernym "http://identifiers.org/go/GO:0043241" - J113 parthood "http://identifiers.org/go/GO:0051396" - J115 hypernym "http://identifiers.org/go/GO:0042169", - "http://identifiers.org/go/GO:0051425" - J116 hypernym "http://identifiers.org/go/GO:0042169", - "http://identifiers.org/go/GO:0051425" - J117 hypernym "http://identifiers.org/go/GO:0005070" - J119 hypernym "http://identifiers.org/go/GO:0031625" - J118 hypernym "http://identifiers.org/go/GO:0051425" - J120 hypernym "http://identifiers.org/go/GO:0051425" - J121 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0006470" - J122 hypernym "http://identifiers.org/ec-code/3.1.3.16", - "http://identifiers.org/go/GO:0006470" - J123 hypernym "http://identifiers.org/go/GO:0006468" - J124 hypernym "http://identifiers.org/go/GO:0043241" - J133 parthood "http://identifiers.org/go/GO:0000187" - J134 parthood "http://identifiers.org/go/GO:0000187" - J135 parthood "http://identifiers.org/go/GO:0000187" - J136 hypernym "http://identifiers.org/go/GO:0043241" - J137 hypernym "http://identifiers.org/go/GO:0043241" - J138 hypernym "http://identifiers.org/go/GO:0043241" - J139 hypernym "http://identifiers.org/go/GO:0043241" - J140 hypernym "http://identifiers.org/go/GO:0019899" - J141 hypernym "http://identifiers.org/go/GO:0019899" - J142 hypernym "http://identifiers.org/go/GO:0019899" - J143 hypernym "http://identifiers.org/go/GO:0019899" - J144 hypernym "http://identifiers.org/go/GO:0019899" - J145 hypernym "http://identifiers.org/go/GO:0019899" - J146 hypernym "http://identifiers.org/go/GO:0019899" - J147 hypernym "http://identifiers.org/go/GO:0019899" - J148 hypernym "http://identifiers.org/go/GO:0019899" - J149 hypernym "http://identifiers.org/go/GO:0019899" - J150 hypernym "http://identifiers.org/go/GO:0019899" - J151 hypernym "http://identifiers.org/go/GO:0019899" - J152 hypernym "http://identifiers.org/go/GO:0004709" - J153 hypernym "http://identifiers.org/go/GO:0004709" - J154 hypernym "http://identifiers.org/go/GO:0004709" - J155 hypernym "http://identifiers.org/go/GO:0004709" - J156 hypernym "http://identifiers.org/go/GO:0004709" - J157 hypernym "http://identifiers.org/go/GO:0004709" - J158 hypernym "http://identifiers.org/go/GO:0004709" - J159 hypernym "http://identifiers.org/go/GO:0004709" - J160 hypernym "http://identifiers.org/go/GO:0004709" - J161 hypernym "http://identifiers.org/go/GO:0004709" - J162 hypernym "http://identifiers.org/go/GO:0004709" - J163 hypernym "http://identifiers.org/go/GO:0004709" - J164 hypernym "http://identifiers.org/go/GO:0043241" - J165 parthood "http://identifiers.org/go/GO:0000188" - J166 parthood "http://identifiers.org/go/GO:0000188" - J167 parthood "http://identifiers.org/go/GO:0043241" - J167 parthood "http://identifiers.org/go/GO:0000188" - J168 parthood "http://identifiers.org/go/GO:0000188" - J168 parthood "http://identifiers.org/go/GO:0043241" -end - -Sasagawa2005_MAPK is "Sasagawa2005_MAPK" - -Sasagawa2005_MAPK model_entity_is "http://identifiers.org/biomodels.db/MODEL6624243033" -Sasagawa2005_MAPK model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000049" -Sasagawa2005_MAPK description "http://identifiers.org/pubmed/15793571" -Sasagawa2005_MAPK origin "http://identifiers.org/biomodels.db/MODEL9071122126", - "http://identifiers.org/biomodels.db/BIOMD0000000019", - "http://identifiers.org/biomodels.db/MODEL9070467164", - "http://identifiers.org/biomodels.db/MODEL9079179924", - "http://identifiers.org/biomodels.db/BIOMD0000000146", - "http://identifiers.org/pubmed/11024454", - "http://identifiers.org/pubmed/11832340", - "http://identifiers.org/pubmed/14751248" -Sasagawa2005_MAPK taxon "http://identifiers.org/taxonomy/10114" -Sasagawa2005_MAPK part "http://identifiers.org/go/GO:0007173", - "http://identifiers.org/go/GO:0007265", - "http://identifiers.org/go/GO:0048011", - "http://identifiers.org/go/GO:0000165" -Sasagawa2005_MAPK property "http://identifiers.org/mamo/MAMO_0000046" -Sasagawa2005_MAPK hypernym "http://identifiers.org/go/GO:0070371" diff --git a/BioModelsRAG/data/BIOMD0000000050.txt b/BioModelsRAG/data/BIOMD0000000050.txt deleted file mode 100644 index 00c41f48fb8ec458fc06445bb3fc1f488ac68fb4..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000050.txt +++ /dev/null @@ -1,101 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Kinetic_modelling_of_Amadori_degradation() - - // Compartments and Species: - compartment compartment_; - species DFG in compartment_, E1 in compartment_, E2 in compartment_, Cn in compartment_; - species Gly in compartment_, _3DG in compartment_, FA in compartment_, _1DG in compartment_; - species AA in compartment_, Man in compartment_, Glu in compartment_, MG in compartment_; - species Mel in compartment_, Fru in compartment_; - - // Reactions: - v1: DFG => E1; v1_k1*DFG; - v2: DFG => E2; v2_k2*DFG; - v3: DFG => Gly + Cn; v3_k3*DFG; - v4: E1 => Gly + _3DG; v4_k4*E1; - v5: _3DG => Cn; v5_k5*_3DG; - v6: _3DG => FA; v6_k6*_3DG; - v7: E2 => Gly + _1DG; v7_k7*E2; - v8: _1DG => Cn; v8_k8*_1DG; - v9: _1DG => AA; v9_k9*_1DG; - v10: E1 => Gly + Man; v10_k10*E1; - v11: E1 => Gly + Glu; v11_k11*E1; - v12: Man => Glu; v12_k12*Man; - v13: Glu => _3DG; v13_k13*Glu; - v14: Gly + Cn => Mel; v14_k14*Cn*Gly; - v15: Cn => AA + FA + MG; v15_k15*Cn; - v16: E2 => Gly + Fru; v16_k16*E2; - - // Species initializations: - DFG = 9; - E1 = 0; - E2 = 0; - Cn = 0; - Gly = 0; - _3DG = 0; - FA = 0; - _1DG = 0; - AA = 0; - Man = 0; - Glu = 0; - MG = 0; - Mel = 0; - Fru = 0; - - // Compartment initializations: - compartment_ = 1; - - // Variable initializations: - v1_k1 = 0.0057; - v2_k2 = 0.0156; - v3_k3 = 0.0155; - v4_k4 = 0.0794; - v5_k5 = 0.0907; - v6_k6 = 0.0274; - v7_k7 = 0.2125; - v8_k8 = 0; - v9_k9 = 1.9085; - v10_k10 = 0.0707; - v11_k11 = 0.1131; - v12_k12 = 0.0008; - v13_k13 = 0.0022; - v14_k14 = 0.0034; - v15_k15 = 0.0159; - v16_k16 = 0.0134; - - // Other declarations: - const compartment_; - - // Unit definitions: - unit substance = 1e-6 mole; - unit time_unit = 60 second; - - // Display Names: - substance is "micromole (default)"; - time_unit is "minute (default)"; - - // CV terms: - Cn hypernym "http://identifiers.org/chebi/CHEBI:23008" - Gly identity "http://identifiers.org/chebi/CHEBI:15428", - "http://identifiers.org/kegg.compound/C00037" - FA identity "http://identifiers.org/chebi/CHEBI:30751", - "http://identifiers.org/kegg.compound/C00058" - AA identity "http://identifiers.org/chebi/CHEBI:15366", - "http://identifiers.org/kegg.compound/C00033" - Man identity "http://identifiers.org/chebi/CHEBI:14575", - "http://identifiers.org/kegg.compound/C00159" - Glu identity "http://identifiers.org/chebi/CHEBI:17234", - "http://identifiers.org/kegg.compound/C00293" - MG identity "http://identifiers.org/chebi/CHEBI:17158", - "http://identifiers.org/kegg.compound/C00546" - Fru identity "http://identifiers.org/chebi/CHEBI:28757", - "http://identifiers.org/kegg.compound/C01496" -end - -Kinetic_modelling_of_Amadori_degradation is "Martins2003_AmadoriDegradation" - -Kinetic_modelling_of_Amadori_degradation model_entity_is "http://identifiers.org/biomodels.db/MODEL7981660691" -Kinetic_modelling_of_Amadori_degradation model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000050" -Kinetic_modelling_of_Amadori_degradation description "http://identifiers.org/pubmed/12873422" -Kinetic_modelling_of_Amadori_degradation taxon "http://identifiers.org/taxonomy/131567" -Kinetic_modelling_of_Amadori_degradation hypernym "http://identifiers.org/go/GO:1901575" diff --git a/BioModelsRAG/data/BIOMD0000000051.txt b/BioModelsRAG/data/BIOMD0000000051.txt deleted file mode 100644 index afeb2e15833d3a6887008b79e7611339edb0faad..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000051.txt +++ /dev/null @@ -1,601 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Chassagnole2002_Carbon_Metabolism() - - // Compartments and Species: - compartment extracellular, cytosol; - species cpep in cytosol, cglcex in extracellular, cg6p in cytosol, cpyr in cytosol; - species cf6p in cytosol, cg1p in cytosol, cpg in cytosol, cfdp in cytosol; - species csed7p in cytosol, cgap in cytosol, ce4p in cytosol, cxyl5p in cytosol; - species crib5p in cytosol, cdhap in cytosol, cpgp in cytosol, cpg3 in cytosol; - species cpg2 in cytosol, cribu5p in cytosol; - - // Assignment Rules: - catp := 4.27 - 4.163*(time/(0.657 + 1.43*time + 0.0364*time^2)); - cadp := 0.582 + 1.73*2.731^(-0.15*time)*(0.12*time + 0.000214*time^3); - camp := 0.123 + 7.25*(time/(7.25 + 1.47*time + 0.17*time^2)) + 1.073/(1.29 + 8.05*time); - cnadp := (0.159 - 0.00554*(time/((2.8 - 0.271*time) + 0.01*time^2))) + 0.182/(4.82 + 0.526*time); - cnadph := 0.062 + 0.332*2.718^(-0.464*time)*(0.0166*time^1.58 + 0.000166*time^4.73 + 0.1312*10^-9*time^7.89 + 0.1362*10^-12*time^11 + 0.1233*10^-15*time^14.2); - cnad := 1.314 + 1.314*2.73^(-0.0435*time - 0.342) - (time + 7.871)*(2.73^(-0.0218*time - 0.171)/(8.481 + time)); - cnadh := 0.0934 + 0.00111*2.371^(-0.123*time)*(0.844*time + 0.104*time^3); - - // Reactions: - vPTS: cglcex + 65 cpep -> 65 cg6p + 65 cpyr; extracellular*vPTS_rmaxPTS*cglcex*(cpep/cpyr)/((vPTS_KPTSa1 + vPTS_KPTSa2*(cpep/cpyr) + vPTS_KPTSa3*cglcex + cglcex*(cpep/cpyr))*(1 + cg6p^vPTS_nPTSg6p/vPTS_KPTSg6p)); - vPGI: cg6p -> cf6p; cytosol*vPGI_rmaxPGI*(cg6p - cf6p/vPGI_KPGIeq)/(vPGI_KPGIg6p*(1 + cf6p/(vPGI_KPGIf6p*(1 + cpg/vPGI_KPGIf6ppginh)) + cpg/vPGI_KPGIg6ppginh) + cg6p); - vPGM: cg6p -> cg1p; cytosol*vPGM_rmaxPGM*(cg6p - cg1p/vPGM_KPGMeq)/(vPGM_KPGMg6p*(1 + cg1p/vPGM_KPGMg1p) + cg6p); - vG6PDH: cg6p -> cpg; cytosol*vG6PDH_rmaxG6PDH*cg6p*cnadp/((cg6p + vG6PDH_KG6PDHg6p)*(1 + cnadph/vG6PDH_KG6PDHnadphg6pinh)*(vG6PDH_KG6PDHnadp*(1 + cnadph/vG6PDH_KG6PDHnadphnadpinh) + cnadp)); - vPFK: cf6p -> cfdp; cytosol*vPFK_rmaxPFK*catp*cf6p/((catp + vPFK_KPFKatps*(1 + cadp/vPFK_KPFKadpc))*(cf6p + vPFK_KPFKf6ps*(1 + cpep/vPFK_KPFKpep + cadp/vPFK_KPFKadpb + camp/vPFK_KPFKampb)/(1 + cadp/vPFK_KPFKadpa + camp/vPFK_KPFKampa))*(1 + vPFK_LPFK/(1 + cf6p*(1 + cadp/vPFK_KPFKadpa + camp/vPFK_KPFKampa)/(vPFK_KPFKf6ps*(1 + cpep/vPFK_KPFKpep + cadp/vPFK_KPFKadpb + camp/vPFK_KPFKampb)))^vPFK_nPFK)); - vTA: cgap + csed7p -> cf6p + ce4p; cytosol*vTA_rmaxTA*(cgap*csed7p - ce4p*cf6p/vTA_KTAeq); - vTKA: crib5p + cxyl5p -> cgap + csed7p; cytosol*vTKA_rmaxTKa*(crib5p*cxyl5p - csed7p*cgap/vTKA_KTKaeq); - vTKB: ce4p + cxyl5p -> cgap + cf6p; cytosol*vTKB_rmaxTKb*(cxyl5p*ce4p - cf6p*cgap/vTKB_KTKbeq); - vMURSyNTH: 2 cf6p -> ; cytosol*vMURSyNTH_rmaxMurSynth; - vALDO: cfdp -> cdhap + cgap; cytosol*vALDO_rmaxALDO*(cfdp - cgap*cdhap/vALDO_kALDOeq)/(vALDO_kALDOfdp + cfdp + vALDO_kALDOgap*cdhap/(vALDO_kALDOeq*vALDO_VALDOblf) + vALDO_kALDOdhap*cgap/(vALDO_kALDOeq*vALDO_VALDOblf) + cfdp*cgap/vALDO_kALDOgapinh + cgap*cdhap/(vALDO_VALDOblf*vALDO_kALDOeq)); - vGAPDH: cgap -> cpgp; cytosol*vGAPDH_rmaxGAPDH*(cgap*cnad - cpgp*cnadh/vGAPDH_KGAPDHeq)/((vGAPDH_KGAPDHgap*(1 + cpgp/vGAPDH_KGAPDHpgp) + cgap)*(vGAPDH_KGAPDHnad*(1 + cnadh/vGAPDH_KGAPDHnadh) + cnad)); - vTIS: cdhap -> cgap; cytosol*vTIS_rmaxTIS*(cdhap - cgap/vTIS_kTISeq)/(vTIS_kTISdhap*(1 + cgap/vTIS_kTISgap) + cdhap); - vTRPSYNTH: -> cpyr + cgap; cytosol*vTRPSYNTH_rmaxTrpSynth; - vG3PDH: cdhap -> ; cytosol*vG3PDH_rmaxG3PDH*cdhap/(vG3PDH_KG3PDHdhap + cdhap); - vPGK: cpgp -> cpg3; cytosol*vPGK_rmaxPGK*(cadp*cpgp - catp*cpg3/vPGK_KPGKeq)/((vPGK_KPGKadp*(1 + catp/vPGK_KPGKatp) + cadp)*(vPGK_KPGKpgp*(1 + cpg3/vPGK_KPGKpg3) + cpgp)); - vsersynth: cpg3 -> ; cytosol*vsersynth_rmaxSerSynth*cpg3/(vsersynth_KSerSynthpg3 + cpg3); - vrpGluMu: cpg3 -> cpg2; cytosol*vrpGluMu_rmaxPGluMu*(cpg3 - cpg2/vrpGluMu_KPGluMueq)/(vrpGluMu_KPGluMupg3*(1 + cpg2/vrpGluMu_KPGluMupg2) + cpg3); - vENO: cpg2 -> cpep; cytosol*vENO_rmaxENO*(cpg2 - cpep/vENO_KENOeq)/(vENO_KENOpg2*(1 + cpep/vENO_KENOpep) + cpg2); - vPK: cpep -> cpyr; cytosol*vPK_rmaxPK*cpep*(cpep/vPK_KPKpep + 1)^(vPK_nPK - 1)*cadp/(vPK_KPKpep*(vPK_LPK*((1 + catp/vPK_KPKatp)/(cfdp/vPK_KPKfdp + camp/vPK_KPKamp + 1))^vPK_nPK + (cpep/vPK_KPKpep + 1)^vPK_nPK)*(cadp + vPK_KPKadp)); - vpepCxylase: cpep -> ; cytosol*vpepCxylase_rmaxpepCxylase*cpep*(1 + (cfdp/vpepCxylase_KpepCxylasefdp)^vpepCxylase_npepCxylasefdp)/(vpepCxylase_KpepCxylasepep + cpep); - vSynth1: cpep -> ; cytosol*vSynth1_rmaxSynth1*cpep/(vSynth1_KSynth1pep + cpep); - vSynth2: cpyr -> ; cytosol*vSynth2_rmaxSynth2*cpyr/(vSynth2_KSynth2pyr + cpyr); - vDAHPS: ce4p + cpep -> ; cytosol*vDAHPS_rmaxDAHPS*ce4p^vDAHPS_nDAHPSe4p*cpep^vDAHPS_nDAHPSpep/((vDAHPS_KDAHPSe4p + ce4p^vDAHPS_nDAHPSe4p)*(vDAHPS_KDAHPSpep + cpep^vDAHPS_nDAHPSpep)); - vPDH: cpyr -> ; cytosol*vPDH_rmaxPDH*cpyr^vPDH_nPDH/(vPDH_KPDHpyr + cpyr^vPDH_nPDH); - vMethSynth: -> cpyr; cytosol*vMethSynth_rmaxMetSynth; - vPGDH: cpg -> cribu5p; cytosol*vPGDH_rmaxPGDH*cpg*cnadp/((cpg + vPGDH_KPGDHpg)*(cnadp + vPGDH_KPGDHnadp*(1 + cnadph/vPGDH_KPGDHnadphinh)*(1 + catp/vPGDH_KPGDHatpinh))); - vR5PI: cribu5p -> crib5p; cytosol*vR5PI_rmaxR5PI*(cribu5p - crib5p/vR5PI_KR5PIeq); - vRu5P: cribu5p -> cxyl5p; cytosol*vRu5P_rmaxRu5P*(cribu5p - cxyl5p/vRu5P_KRu5Peq); - vPPK: crib5p -> ; cytosol*vPPK_rmaxRPPK*crib5p/(vPPK_KRPPKrib5p + crib5p); - vG1PAT: cg1p -> ; cytosol*vG1PAT_rmaxG1PAT*cg1p*catp*(1 + (cfdp/vG1PAT_KG1PATfdp)^vG1PAT_nG1PATfdp)/((vG1PAT_KG1PATatp + catp)*(vG1PAT_KG1PATg1p + cg1p)); - vG6P: cg6p -> ; cytosol*vG6P_mu*cg6p; - vf6P: cf6p -> ; cytosol*vf6P_mu*cf6p; - vfdP: cfdp -> ; cytosol*vfdP_mu*cfdp; - vGAP: cgap -> ; cytosol*vGAP_mu*cgap; - vDHAP: cdhap -> ; cytosol*vDHAP_mu*cdhap; - vPGP: cpgp -> ; cytosol*vPGP_mu*cpgp; - vPG3: cpg3 -> ; cytosol*vPG3_mu*cpg3; - vpg2: cpg2 -> ; cytosol*vpg2_mu*cpg2; - vPEP: cpep -> ; cytosol*vPEP_mu*cpep; - vRibu5p: cribu5p -> ; cytosol*vRibu5p_mu*cribu5p; - vRIB5P: crib5p -> ; cytosol*vRIB5P_mu*crib5p; - vXYL5P: cxyl5p -> ; cytosol*vXYL5P_mu*cxyl5p; - vSED7P: csed7p -> ; cytosol*vSED7P_mu*csed7p; - vpyr: cpyr -> ; cytosol*vpyr_mu*cpyr; - vPG: cpg -> ; cytosol*vPG_mu*cpg; - vE4P: ce4p -> ; cytosol*vE4P_mu*ce4p; - vGLP: cg1p -> ; cytosol*vGLP_mu*cg1p; - vEXTER: -> cglcex; extracellular*vEXTER_Dil*(vEXTER_cfeed - cglcex); - - // Species initializations: - cpep = 2.67; - cglcex = 2; - cg6p = 3.48; - cpyr = 2.67; - cf6p = 0.6; - cg1p = 0.653; - cpg = 0.808; - cfdp = 0.272; - csed7p = 0.276; - cgap = 0.218; - ce4p = 0.098; - cxyl5p = 0.138; - crib5p = 0.398; - cdhap = 0.167; - cpgp = 0.008; - cpg3 = 2.13; - cpg2 = 0.399; - cribu5p = 0.111; - - // Compartment initializations: - extracellular = 1; - cytosol = 1; - catp has mM; - cadp has mM; - camp has mM; - cnadp has mM; - cnadph has mM; - cnad has mM; - cnadh has mM; - - // Variable initializations: - vPTS_rmaxPTS = 7829.78; - vPTS_rmaxPTS has mM_per_second; - vPTS_KPTSa1 = 3082.3; - vPTS_KPTSa1 has mM; - vPTS_KPTSa2 = 0.01; - vPTS_KPTSa2 has mM; - vPTS_KPTSa3 = 245.3; - vPTS_KPTSa3 has dimensionless; - vPTS_nPTSg6p = 3.66; - vPTS_nPTSg6p has dimensionless; - vPTS_KPTSg6p = 2.15; - vPTS_KPTSg6p has mM; - vPGI_rmaxPGI = 650.9878687; - vPGI_rmaxPGI has mM_per_second; - vPGI_KPGIeq = 0.1725; - vPGI_KPGIeq has dimensionless; - vPGI_KPGIg6p = 2.9; - vPGI_KPGIg6p has mM; - vPGI_KPGIf6p = 0.266; - vPGI_KPGIf6p has mM; - vPGI_KPGIf6ppginh = 0.2; - vPGI_KPGIf6ppginh has mM; - vPGI_KPGIg6ppginh = 0.2; - vPGI_KPGIg6ppginh has mM; - vPGM_rmaxPGM = 0.8398242773; - vPGM_rmaxPGM has mM_per_second; - vPGM_KPGMeq = 0.196; - vPGM_KPGMeq has dimensionless; - vPGM_KPGMg6p = 1.038; - vPGM_KPGMg6p has mM; - vPGM_KPGMg1p = 0.0136; - vPGM_KPGMg1p has mM; - vG6PDH_rmaxG6PDH = 1.380196955; - vG6PDH_rmaxG6PDH has mM_per_second; - vG6PDH_KG6PDHg6p = 14.4; - vG6PDH_KG6PDHg6p has mM; - vG6PDH_KG6PDHnadphg6pinh = 6.43; - vG6PDH_KG6PDHnadphg6pinh has mM; - vG6PDH_KG6PDHnadp = 0.0246; - vG6PDH_KG6PDHnadp has mM; - vG6PDH_KG6PDHnadphnadpinh = 0.01; - vG6PDH_KG6PDHnadphnadpinh has mM; - vPFK_rmaxPFK = 1840.584747; - vPFK_rmaxPFK has mM_per_second; - vPFK_KPFKatps = 0.123; - vPFK_KPFKatps has mM; - vPFK_KPFKadpc = 4.14; - vPFK_KPFKadpc has mM; - vPFK_KPFKf6ps = 0.325; - vPFK_KPFKf6ps has mM; - vPFK_KPFKpep = 3.26; - vPFK_KPFKpep has mM; - vPFK_KPFKadpb = 3.89; - vPFK_KPFKadpb has mM; - vPFK_KPFKampb = 3.2; - vPFK_KPFKampb has mM; - vPFK_KPFKadpa = 128; - vPFK_KPFKadpa has mM; - vPFK_KPFKampa = 19.1; - vPFK_KPFKampa has mM; - vPFK_LPFK = 5629067; - vPFK_LPFK has dimensionless; - vPFK_nPFK = 11.1; - vPFK_nPFK has dimensionless; - vTA_rmaxTA = 10.87164108; - vTA_rmaxTA has per_mM_per_second; - vTA_KTAeq = 1.05; - vTA_KTAeq has dimensionless; - vTKA_rmaxTKa = 9.473384783; - vTKA_rmaxTKa has per_mM_per_second; - vTKA_KTKaeq = 1.2; - vTKA_KTKaeq has dimensionless; - vTKB_rmaxTKb = 86.55855855; - vTKB_rmaxTKb has per_mM_per_second; - vTKB_KTKbeq = 10; - vTKB_KTKbeq has dimensionless; - vMURSyNTH_rmaxMurSynth = 0.00043711; - vMURSyNTH_rmaxMurSynth has mM_per_second; - vALDO_rmaxALDO = 17.41464425; - vALDO_rmaxALDO has mM_per_second; - vALDO_kALDOeq = 0.144; - vALDO_kALDOeq has mM; - vALDO_kALDOfdp = 1.75; - vALDO_kALDOfdp has mM; - vALDO_kALDOgap = 0.088; - vALDO_kALDOgap has mM; - vALDO_VALDOblf = 2; - vALDO_VALDOblf has dimensionless; - vALDO_kALDOdhap = 0.088; - vALDO_kALDOdhap has mM; - vALDO_kALDOgapinh = 0.6; - vALDO_kALDOgapinh has mM; - vGAPDH_rmaxGAPDH = 921.5942861; - vGAPDH_rmaxGAPDH has mM_per_second; - vGAPDH_KGAPDHeq = 0.63; - vGAPDH_KGAPDHeq has dimensionless; - vGAPDH_KGAPDHgap = 0.683; - vGAPDH_KGAPDHgap has mM; - vGAPDH_KGAPDHpgp = 1.04e-05; - vGAPDH_KGAPDHpgp has mM; - vGAPDH_KGAPDHnad = 0.252; - vGAPDH_KGAPDHnad has mM; - vGAPDH_KGAPDHnadh = 1.09; - vGAPDH_KGAPDHnadh has mM; - vTIS_rmaxTIS = 68.67474392; - vTIS_rmaxTIS has mM_per_second; - vTIS_kTISeq = 1.39; - vTIS_kTISeq has dimensionless; - vTIS_kTISdhap = 2.8; - vTIS_kTISdhap has mM; - vTIS_kTISgap = 0.3; - vTIS_kTISgap has mM; - vTRPSYNTH_rmaxTrpSynth = 0.001037; - vTRPSYNTH_rmaxTrpSynth has mM_per_second; - vG3PDH_rmaxG3PDH = 0.01162042696; - vG3PDH_rmaxG3PDH has mM_per_second; - vG3PDH_KG3PDHdhap = 1; - vG3PDH_KG3PDHdhap has mM; - vPGK_rmaxPGK = 3021.773771; - vPGK_rmaxPGK has mM_per_second; - vPGK_KPGKeq = 1934.4; - vPGK_KPGKeq has dimensionless; - vPGK_KPGKadp = 0.185; - vPGK_KPGKadp has mM; - vPGK_KPGKatp = 0.653; - vPGK_KPGKatp has mM; - vPGK_KPGKpgp = 0.0468; - vPGK_KPGKpgp has mM; - vPGK_KPGKpg3 = 0.473; - vPGK_KPGKpg3 has mM; - vsersynth_rmaxSerSynth = 0.025712107; - vsersynth_rmaxSerSynth has mM_per_second; - vsersynth_KSerSynthpg3 = 1; - vsersynth_KSerSynthpg3 has mM; - vrpGluMu_rmaxPGluMu = 89.04965407; - vrpGluMu_rmaxPGluMu has mM_per_second; - vrpGluMu_KPGluMueq = 0.188; - vrpGluMu_KPGluMueq has dimensionless; - vrpGluMu_KPGluMupg3 = 0.2; - vrpGluMu_KPGluMupg3 has mM; - vrpGluMu_KPGluMupg2 = 0.369; - vrpGluMu_KPGluMupg2 has mM; - vENO_rmaxENO = 330.4476151; - vENO_rmaxENO has mM_per_second; - vENO_KENOeq = 6.73; - vENO_KENOeq has mM; - vENO_KENOpg2 = 0.1; - vENO_KENOpg2 has mM; - vENO_KENOpep = 0.135; - vENO_KENOpep has mM; - vPK_rmaxPK = 0.06113150238; - vPK_rmaxPK has mM_per_second; - vPK_KPKpep = 0.31; - vPK_KPKpep has mM; - vPK_nPK = 4; - vPK_nPK has dimensionless; - vPK_LPK = 1000; - vPK_LPK has dimensionless; - vPK_KPKatp = 22.5; - vPK_KPKatp has mM; - vPK_KPKfdp = 0.19; - vPK_KPKfdp has mM; - vPK_KPKamp = 0.2; - vPK_KPKamp has mM; - vPK_KPKadp = 0.26; - vPK_KPKadp has mM; - vpepCxylase_rmaxpepCxylase = 0.1070205858; - vpepCxylase_rmaxpepCxylase has mM_per_second; - vpepCxylase_KpepCxylasefdp = 0.7; - vpepCxylase_KpepCxylasefdp has mM; - vpepCxylase_npepCxylasefdp = 4.21; - vpepCxylase_npepCxylasefdp has dimensionless; - vpepCxylase_KpepCxylasepep = 4.07; - vpepCxylase_KpepCxylasepep has mM; - vSynth1_rmaxSynth1 = 0.01953897003; - vSynth1_rmaxSynth1 has mM_per_second; - vSynth1_KSynth1pep = 1; - vSynth1_KSynth1pep has mM; - vSynth2_rmaxSynth2 = 0.07361855055; - vSynth2_rmaxSynth2 has mM_per_second; - vSynth2_KSynth2pyr = 1; - vSynth2_KSynth2pyr has mM; - vDAHPS_rmaxDAHPS = 0.1079531227; - vDAHPS_rmaxDAHPS has mM_per_second; - vDAHPS_nDAHPSe4p = 2.6; - vDAHPS_nDAHPSe4p has dimensionless; - vDAHPS_nDAHPSpep = 2.2; - vDAHPS_nDAHPSpep has dimensionless; - vDAHPS_KDAHPSe4p = 0.035; - vDAHPS_KDAHPSe4p has mM; - vDAHPS_KDAHPSpep = 0.0053; - vDAHPS_KDAHPSpep has mM; - vPDH_rmaxPDH = 6.059531017; - vPDH_rmaxPDH has mM_per_second; - vPDH_nPDH = 3.68; - vPDH_nPDH has dimensionless; - vPDH_KPDHpyr = 1159; - vPDH_KPDHpyr has mM; - vMethSynth_rmaxMetSynth = 0.0022627; - vMethSynth_rmaxMetSynth has mM_per_second; - vPGDH_rmaxPGDH = 16.23235977; - vPGDH_rmaxPGDH has mM_per_second; - vPGDH_KPGDHpg = 37.5; - vPGDH_KPGDHpg has mM; - vPGDH_KPGDHnadp = 0.0506; - vPGDH_KPGDHnadp has mM; - vPGDH_KPGDHnadphinh = 0.0138; - vPGDH_KPGDHnadphinh has mM; - vPGDH_KPGDHatpinh = 208; - vPGDH_KPGDHatpinh has mM; - vR5PI_rmaxR5PI = 4.83841193; - vR5PI_rmaxR5PI has second_inverse; - vR5PI_KR5PIeq = 4; - vR5PI_KR5PIeq has dimensionless; - vRu5P_rmaxRu5P = 6.739029475; - vRu5P_rmaxRu5P has second_inverse; - vRu5P_KRu5Peq = 1.4; - vRu5P_KRu5Peq has dimensionless; - vPPK_rmaxRPPK = 0.01290045226; - vPPK_rmaxRPPK has mM_per_second; - vPPK_KRPPKrib5p = 0.1; - vPPK_KRPPKrib5p has mM; - vG1PAT_rmaxG1PAT = 0.007525458026; - vG1PAT_rmaxG1PAT has mM_per_second; - vG1PAT_KG1PATfdp = 0.119; - vG1PAT_KG1PATfdp has mM; - vG1PAT_nG1PATfdp = 1.2; - vG1PAT_nG1PATfdp has mM; - vG1PAT_KG1PATatp = 4.42; - vG1PAT_KG1PATatp has mM; - vG1PAT_KG1PATg1p = 3.2; - vG1PAT_KG1PATg1p has mM; - vG6P_mu = 2.78e-05; - vG6P_mu has second_inverse; - vf6P_mu = 2.78e-05; - vf6P_mu has second_inverse; - vfdP_mu = 2.78e-05; - vfdP_mu has second_inverse; - vGAP_mu = 2.78e-05; - vGAP_mu has second_inverse; - vDHAP_mu = 2.78e-05; - vDHAP_mu has second_inverse; - vPGP_mu = 2.78e-05; - vPGP_mu has second_inverse; - vPG3_mu = 2.78e-05; - vPG3_mu has second_inverse; - vpg2_mu = 2.78e-05; - vpg2_mu has second_inverse; - vPEP_mu = 2.78e-05; - vPEP_mu has second_inverse; - vRibu5p_mu = 2.78e-05; - vRibu5p_mu has second_inverse; - vRIB5P_mu = 2.78e-05; - vRIB5P_mu has second_inverse; - vXYL5P_mu = 2.78e-05; - vXYL5P_mu has second_inverse; - vSED7P_mu = 2.78e-05; - vSED7P_mu has second_inverse; - vpyr_mu = 2.78e-05; - vpyr_mu has second_inverse; - vPG_mu = 2.78e-05; - vPG_mu has second_inverse; - vE4P_mu = 2.78e-05; - vE4P_mu has second_inverse; - vGLP_mu = 2.78e-05; - vGLP_mu has second_inverse; - vEXTER_Dil = 2.78e-05; - vEXTER_Dil has second_inverse; - vEXTER_cfeed = 110.96; - vEXTER_cfeed has mM; - - // Other declarations: - var catp, cadp, camp, cnadp, cnadph, cnad, cnadh; - const extracellular, cytosol; - - // Unit definitions: - unit substance = 1e-3 mole; - unit mM = 1e-3 mole / litre; - unit second_inverse = 1 / second; - unit mM_per_second = 1e-3 mole / (litre * second); - unit per_mM_per_second = litre / (1e-3 mole * second); - - // Display Names: - substance is "millimole"; - mM is "milli Molar"; - second_inverse is "second inverse"; - mM_per_second is "mM per second"; - per_mM_per_second is "per mM per second"; - cpep is "Phosphoenol pyruvate"; - cglcex is "Extracellular Glucose"; - cg6p is "Glucose-6-Phosphate"; - cpyr is "Pyruvate"; - cf6p is "Fructose-6-Phosphate"; - cg1p is "Glucose-1-Phosphate"; - cpg is "6-Phosphogluconate"; - cfdp is "Fructose-1,6-bisphosphate"; - csed7p is "sedoheptulose-7-phosphate"; - cgap is "Glyceraldehyde-3-Phosphate"; - ce4p is "Erythrose-4-phosphate"; - cxyl5p is "Xylulose-5-phosphate"; - crib5p is "Ribose-5-phosphate"; - cdhap is "Dihydroxyacetonephosphate"; - cpgp is "1,3-diphosphosphoglycerate"; - cpg3 is "3-Phosphoglycerate"; - cpg2 is "2-Phosphoglycerate"; - cribu5p is "Ribulose-5-phosphate"; - vPTS is "Phosphotransferase system"; - vPGI is "Glucose-6-phosphate isomerase"; - vPGM is "Phosphoglucomutase"; - vG6PDH is "Glucose-6-phosphate dehydrogenase"; - vPFK is "Phosphofructokinase"; - vTA is "Transaldolase"; - vTKA is "Transketolase a"; - vTKB is "Transketolase b"; - vMURSyNTH is "Mureine synthesis"; - vALDO is "Aldolase"; - vGAPDH is "Glyceraldehyde-3-phosphate dehydrogenase"; - vTIS is "Triosephosphate isomerase"; - vTRPSYNTH is "Tryptophan synthesis"; - vG3PDH is "Glycerol-3-phosphate dehydrogenase"; - vPGK is "Phosphoglycerate kinase"; - vsersynth is "Serine synthesis"; - vrpGluMu is "Phosphoglycerate mutase"; - vENO is "Enolase"; - vPK is "Pyruvate kinase"; - vpepCxylase is "PEP carboxylase"; - vSynth1 is "Synthesis 1"; - vSynth2 is "Synthesis 2"; - vDAHPS is "DAHP synthesis"; - vPDH is "Pyruvate dehydrogenase"; - vMethSynth is "Methionine synthesis"; - vPGDH is "6-Phosphogluconate dehydrogenase"; - vR5PI is "Ribose-phosphate isomerase"; - vRu5P is "Ribulose-phosphate epimerase"; - vPPK is "Ribose phosphate pyrophosphokinase"; - vG1PAT is "Glucose-1-phosphate adenyltransferase"; - vG6P is "G6P degradation"; - vf6P is "F6P degradation"; - vfdP is "FDP degradation"; - vGAP is "GAP degradation"; - vDHAP is "DHAP degradation"; - vPGP is "PGP degradation"; - vPG3 is "PG3 degradation"; - vpg2 is "PG2 degradation"; - vPEP is "PEP degradation"; - vRibu5p is "Ribu5P dilution"; - vRIB5P is "Rib5P dilution"; - vXYL5P is "XYL5P dilution"; - vSED7P is "SED7P dilution"; - vpyr is "Pyruvate dilution"; - vPG is "PG dilution"; - vE4P is "E4P dilution"; - vGLP is "GLP dilution"; - vEXTER is "Extracellular glucose kinetics"; - - // CV terms: - extracellular identity "http://identifiers.org/go/GO:0005576" - cytosol identity "http://identifiers.org/go/GO:0005829" - cpep identity "http://identifiers.org/chebi/CHEBI:18021", - "http://identifiers.org/kegg.compound/C00074" - cglcex identity "http://identifiers.org/chebi/CHEBI:4167" - cglcex identity "http://identifiers.org/kegg.compound/C00031", - "http://identifiers.org/chebi/CHEBI:4167" - cglcex hypernym "http://identifiers.org/chebi/CHEBI:17234", - "http://identifiers.org/kegg.compound/C00293" - cg6p identity "http://identifiers.org/chebi/CHEBI:17665", - "http://identifiers.org/kegg.compound/C00668" - cpyr identity "http://identifiers.org/chebi/CHEBI:15361", - "http://identifiers.org/kegg.compound/C00022" - cf6p identity "http://identifiers.org/kegg.compound/C05345", - "http://identifiers.org/chebi/CHEBI:16084" - cf6p hypernym "http://identifiers.org/kegg.compound/C00085", - "http://identifiers.org/chebi/CHEBI:15946" - cf6p hypernym "http://identifiers.org/chebi/CHEBI:15946" - cg1p identity "http://identifiers.org/chebi/CHEBI:16077", - "http://identifiers.org/kegg.compound/C00103" - cpg identity "http://identifiers.org/chebi/CHEBI:16863", - "http://identifiers.org/kegg.compound/C00345" - cfdp identity "http://identifiers.org/chebi/CHEBI:16905", - "http://identifiers.org/kegg.compound/C00354" - csed7p identity "http://identifiers.org/chebi/CHEBI:15721", - "http://identifiers.org/kegg.compound/C00281" - cgap identity "http://identifiers.org/chebi/CHEBI:17138", - "http://identifiers.org/kegg.compound/C00661" - ce4p identity "http://identifiers.org/chebi/CHEBI:48153", - "http://identifiers.org/kegg.compound/C00279" - cxyl5p identity "http://identifiers.org/chebi/CHEBI:16332", - "http://identifiers.org/kegg.compound/C00231" - crib5p identity "http://identifiers.org/chebi/CHEBI:17797", - "http://identifiers.org/kegg.compound/C00117" - cdhap identity "http://identifiers.org/chebi/CHEBI:16108", - "http://identifiers.org/kegg.compound/C00111" - cpgp identity "http://identifiers.org/chebi/CHEBI:16001", - "http://identifiers.org/kegg.compound/C00236" - cpg3 identity "http://identifiers.org/chebi/CHEBI:17794", - "http://identifiers.org/kegg.compound/C00197" - cpg2 identity "http://identifiers.org/chebi/CHEBI:17835", - "http://identifiers.org/kegg.compound/C00631" - cribu5p identity "http://identifiers.org/chebi/CHEBI:17363", - "http://identifiers.org/kegg.compound/C00199" - vPTS identity "http://identifiers.org/kegg.pathway/eco02060" - vPGI homolog "http://identifiers.org/reactome/REACT_1255" - vPGI identity "http://identifiers.org/kegg.reaction/R00771" - vPGI hypernym "http://identifiers.org/ec-code/5.3.1.9", - "http://identifiers.org/go/GO:0004347" - vPGM homolog "http://identifiers.org/reactome/REACT_605" - vPGM identity "http://identifiers.org/kegg.reaction/R00959" - vPGM hypernym "http://identifiers.org/ec-code/5.4.2.2" - vG6PDH part "http://identifiers.org/kegg.reaction/R00835", - "http://identifiers.org/kegg.reaction/R02035" - vG6PDH part "http://identifiers.org/ec-code/1.1.1.49", - "http://identifiers.org/ec-code/3.1.1.31" - vPFK homolog "http://identifiers.org/reactome/REACT_736" - vPFK identity "http://identifiers.org/kegg.reaction/R00756" - vPFK hypernym "http://identifiers.org/ec-code/2.7.1.11" - vTA homolog "http://identifiers.org/reactome/REACT_1272" - vTA identity "http://identifiers.org/kegg.reaction/R01827" - vTA hypernym "http://identifiers.org/ec-code/2.2.1.2" - vTKA homolog "http://identifiers.org/reactome/REACT_162" - vTKA identity "http://identifiers.org/kegg.reaction/R01641" - vTKA hypernym "http://identifiers.org/ec-code/2.2.1.1" - vTKB homolog "http://identifiers.org/reactome/REACT_1811" - vTKB identity "http://identifiers.org/kegg.reaction/R01067" - vTKB hypernym "http://identifiers.org/ec-code/2.2.1.1" - vMURSyNTH hypernym "http://identifiers.org/go/GO:0006002" - vALDO homolog "http://identifiers.org/reactome/REACT_1602" - vALDO identity "http://identifiers.org/kegg.reaction/R01070" - vALDO hypernym "http://identifiers.org/ec-code/4.1.2.13" - vGAPDH homolog "http://identifiers.org/reactome/REACT_1847" - vGAPDH identity "http://identifiers.org/kegg.reaction/R01061" - vGAPDH hypernym "http://identifiers.org/ec-code/1.2.1.12" - vTIS homolog "http://identifiers.org/reactome/REACT_469" - vTIS identity "http://identifiers.org/kegg.reaction/R01015" - vTIS hypernym "http://identifiers.org/ec-code/5.3.1.1" - vTRPSYNTH hypernym "http://identifiers.org/go/GO:0000162" - vG3PDH homolog "http://identifiers.org/reactome/REACT_16938" - vG3PDH identity "http://identifiers.org/kegg.reaction/R00842" - vG3PDH hypernym "http://identifiers.org/ec-code/1.1.1.8" - vPGK homolog "http://identifiers.org/reactome/REACT_1186" - vPGK identity "http://identifiers.org/kegg.reaction/R01512" - vPGK hypernym "http://identifiers.org/ec-code/2.7.2.3" - vsersynth hypernym "http://identifiers.org/go/GO:0009070" - vrpGluMu homolog "http://identifiers.org/reactome/REACT_576" - vrpGluMu identity "http://identifiers.org/kegg.reaction/R01518" - vrpGluMu hypernym "http://identifiers.org/ec-code/5.4.2.1" - vENO homolog "http://identifiers.org/reactome/REACT_1400" - vENO identity "http://identifiers.org/kegg.reaction/R00658" - vENO hypernym "http://identifiers.org/ec-code/4.2.1.11" - vPK homolog "http://identifiers.org/reactome/REACT_1524" - vPK identity "http://identifiers.org/kegg.reaction/R00200" - vPK hypernym "http://identifiers.org/ec-code/2.7.1.40" - vpepCxylase identity "http://identifiers.org/kegg.reaction/R00345" - vpepCxylase hypernym "http://identifiers.org/ec-code/4.1.1.31" - vSynth1 hypernym "http://identifiers.org/go/GO:0009423" - vSynth2 part "http://identifiers.org/go/GO:0006523", - "http://identifiers.org/go/GO:0009097", - "http://identifiers.org/go/GO:0019877" - vDAHPS identity "http://identifiers.org/kegg.reaction/R01826" - vDAHPS hypernym "http://identifiers.org/ec-code/2.5.1.54" - vPDH hypernym "http://identifiers.org/ec-code/1.2.1.51" - vPDH identity "http://identifiers.org/kegg.reaction/R00209" - vPDH parthood "http://identifiers.org/kegg.pathway/rn00620" - vMethSynth hypernym "http://identifiers.org/go/GO:0042866" - vPGDH hypernym "http://identifiers.org/ec-code/1.1.1.44" - vPGDH identity "http://identifiers.org/kegg.reaction/R01528" - vPGDH homolog "http://identifiers.org/reactome/REACT_611" - vR5PI hypernym "http://identifiers.org/ec-code/5.3.1.6" - vR5PI identity "http://identifiers.org/kegg.reaction/R01056" - vR5PI homolog "http://identifiers.org/reactome/REACT_6907" - vRu5P identity "http://identifiers.org/kegg.reaction/R01529" - vRu5P hypernym "http://identifiers.org/ec-code/5.1.3.1" - vRu5P homolog "http://identifiers.org/reactome/REACT_1522" - vPPK identity "http://identifiers.org/kegg.reaction/R01049" - vPPK hypernym "http://identifiers.org/ec-code/2.7.6.1" - vPPK homolog "http://identifiers.org/reactome/REACT_2023" - vG1PAT identity "http://identifiers.org/kegg.reaction/R00948" - vG1PAT hypernym "http://identifiers.org/ec-code/2.7.7.27" - vG6P hypernym "http://identifiers.org/go/GO:0044275" - vf6P hypernym "http://identifiers.org/go/GO:0044275" - vfdP hypernym "http://identifiers.org/go/GO:0044275" - vGAP hypernym "http://identifiers.org/go/GO:0019683" - vDHAP hypernym "http://identifiers.org/go/GO:0044275" - vPGP hypernym "http://identifiers.org/go/GO:0044275" - vPG3 hypernym "http://identifiers.org/go/GO:0044275" - vpg2 hypernym "http://identifiers.org/go/GO:0044275" - vPEP hypernym "http://identifiers.org/go/GO:0046395" -end - -Chassagnole2002_Carbon_Metabolism is "Chassagnole2002_Carbon_Metabolism" - -Chassagnole2002_Carbon_Metabolism model_entity_is "http://identifiers.org/biomodels.db/MODEL6624119661" -Chassagnole2002_Carbon_Metabolism model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000051" -Chassagnole2002_Carbon_Metabolism description "http://identifiers.org/pubmed/17590932" -Chassagnole2002_Carbon_Metabolism part "http://identifiers.org/kegg.pathway/map00030", - "http://identifiers.org/kegg.pathway/map00010" -Chassagnole2002_Carbon_Metabolism part "http://identifiers.org/go/GO:0009401", - "http://identifiers.org/go/GO:0006098", - "http://identifiers.org/go/GO:0006096" -Chassagnole2002_Carbon_Metabolism taxon "http://identifiers.org/taxonomy/562" diff --git a/BioModelsRAG/data/BIOMD0000000052.txt b/BioModelsRAG/data/BIOMD0000000052.txt deleted file mode 100644 index fc265ecb3be00727a2a62b84279ca26fd84c090c..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000052.txt +++ /dev/null @@ -1,85 +0,0 @@ -// Created by libAntimony v2.13.0 -model *MODEL8177704759() - - // Compartments and Species: - compartment compartment_; - species Glu in compartment_, Fru in compartment_, Formic_acid in compartment_; - species Triose in compartment_, Acetic_acid in compartment_, Cn in compartment_; - species Amadori in compartment_, AMP in compartment_, C5 in compartment_; - species lys_R in compartment_, Melanoidin in compartment_; - - // Reactions: - _J1: Glu => Fru; _J1_K1*Glu; - _J2: Fru => Glu; _J2_K2*Fru; - _J3: Glu => C5 + Formic_acid; _J3_K3*Glu; - _J4: Fru => C5 + Formic_acid; _J4_K4*Fru; - _J5: Fru => 2 Triose; _J5_K5*Fru; - _J6: Triose => Cn + Acetic_acid; _J6_K6*Triose; - _J7: lys_R + Glu => Amadori; _J7_K7*Glu*lys_R; - _J8: Amadori => Acetic_acid + lys_R; _J8_K8*Amadori; - _J9: Amadori => AMP; _J9_K9*Amadori; - _J10: lys_R + Fru => AMP; _J10_K10*Fru*lys_R; - _J11: AMP => Melanoidin; _J11_K11*AMP; - - // Species initializations: - Glu = 160; - Fru = 0; - Formic_acid = 0; - Triose = 0; - Acetic_acid = 0; - Cn = 0; - Amadori = 0; - AMP = 0; - C5 = 0; - lys_R = 15; - Melanoidin = 0; - - // Compartment initializations: - compartment_ = 1; - - // Variable initializations: - _J1_K1 = 0.01; - _J2_K2 = 0.00509; - _J3_K3 = 0.00047; - _J4_K4 = 0.0011; - _J5_K5 = 0.00712; - _J6_K6 = 0.00439; - _J7_K7 = 0.00018; - _J8_K8 = 0.11134; - _J9_K9 = 0.14359; - _J10_K10 = 0.00015; - _J11_K11 = 0.12514; - - // Other declarations: - const compartment_; - - // Unit definitions: - unit substance = 1e-3 mole; - unit time_unit = 60 second; - - // Display Names: - substance is "millimole (default)"; - time_unit is "minute (default)"; - - // CV terms: - Glu identity "http://identifiers.org/chebi/CHEBI:17234", - "http://identifiers.org/kegg.compound/C00293" - Fru identity "http://identifiers.org/chebi/CHEBI:28757", - "http://identifiers.org/kegg.compound/C01496" - Formic_acid identity "http://identifiers.org/chebi/CHEBI:30751", - "http://identifiers.org/kegg.compound/C00058" - Acetic_acid identity "http://identifiers.org/chebi/CHEBI:15366", - "http://identifiers.org/kegg.compound/C00033" - lys_R identity "http://identifiers.org/chebi/CHEBI:32568" -end - -MODEL8177704759 is "Brands2002 - Monosaccharide-casein systems" - -MODEL8177704759 model_entity_is "http://identifiers.org/biomodels.db/MODEL8177704759" -MODEL8177704759 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000052" -MODEL8177704759 description "http://identifiers.org/pubmed/12405768" -MODEL8177704759 origin "http://identifiers.org/pubmed/11600005" -MODEL8177704759 taxon "http://identifiers.org/taxonomy/131567" -MODEL8177704759 hypernym "http://identifiers.org/go/GO:0046364", - "http://identifiers.org/go/GO:0048029" -MODEL8177704759 property "http://identifiers.org/mamo/MAMO_0000046" diff --git a/BioModelsRAG/data/BIOMD0000000053.txt b/BioModelsRAG/data/BIOMD0000000053.txt deleted file mode 100644 index 63be9c8ae31598c91716c5190425135231ee1f93..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000053.txt +++ /dev/null @@ -1,96 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Ferreira_CML_generation() - - // Compartments and Species: - compartment compartment_; - species Glucose in compartment_, Lysine in compartment_, Schiff in compartment_; - species Amadori in compartment_, Glyoxal in compartment_, CML in compartment_; - - // Assignment Rules: - Fraction_Amadori := Amadori/0.0034; - Fraction_CML := CML/0.0034; - - // Reactions: - v1a: Lysine + Glucose => Schiff; compartment_*v1a_p1*v1a_k1a*Glucose*Lysine; - v1b: Schiff => Lysine + Glucose; compartment_*v1b_k1b*Schiff; - v2a: Schiff => Amadori; compartment_*v2a_p2*v2a_k2a*Schiff; - v2b: Amadori => Schiff; compartment_*v2b_p2*v2b_k2b*Amadori; - v3: Glucose => Glyoxal; compartment_*v3_ox*v3_p3*v3_k3*(Glucose/0.25)^0.36; - v4: Amadori => CML; compartment_*v4_ox*v4_p4*v4_k4*Amadori; - v5: Lysine + Glyoxal => CML; compartment_*v5_ox*v5_p5*v5_k5*Glyoxal*Lysine; - v5b: Glyoxal => ; compartment_*v5b_k5b*Glyoxal; - v6: Schiff => CML; compartment_*v6_ox*v6_p6*v6_k3*(Schiff/0.25)^0.36; - v7a: => Lysine; compartment_*0.05*v7a_ox*v7a_p7*v7a_k3*(Schiff/0.25)^0.36; - v7b: => Glyoxal; compartment_*0.005*v7b_ox*v7b_p7*v7b_k3*(Schiff/0.25)^0.36; - v7c: Schiff => ; compartment_*v7c_ox*v7c_p7*v7c_k3*(Schiff/0.25)^0.36; - - // Species initializations: - Glucose = 0.25; - Lysine = 0.0034; - Schiff = 0; - Amadori = 0; - Glyoxal = 0; - CML = 0; - - // Compartment initializations: - compartment_ = 1; - - // Variable initializations: - v1a_p1 = 0.115; - v1a_k1a = 0.09; - v1b_k1b = 0.36; - v2a_p2 = 0.75; - v2a_k2a = 0.033; - v2b_p2 = 0.75; - v2b_k2b = 0.0012; - v3_ox = 1; - v3_p3 = 1; - v3_k3 = 7.92e-07; - v4_ox = 1; - v4_p4 = 1; - v4_k4 = 8.6e-05; - v5_ox = 1; - v5_p5 = 1; - v5_k5 = 0.019; - v5b_k5b = 0.0017; - v6_ox = 1; - v6_p6 = 2.7; - v6_k3 = 7.92e-07; - v7a_ox = 1; - v7a_p7 = 60; - v7a_k3 = 7.92e-07; - v7b_ox = 1; - v7b_p7 = 60; - v7b_k3 = 7.92e-07; - v7c_ox = 1; - v7c_p7 = 60; - v7c_k3 = 7.92e-07; - - // Other declarations: - var Fraction_Amadori, Fraction_CML; - const compartment_; - - // Unit definitions: - unit time_unit = 3600 second; - - // Display Names: - time_unit is "hour (default)"; - - // CV terms: - Glucose identity "http://identifiers.org/chebi/CHEBI:17234", - "http://identifiers.org/kegg.compound/C00293" - Lysine identity "http://identifiers.org/chebi/CHEBI:25094" - Glyoxal identity "http://identifiers.org/kegg.compound/C14448", - "http://identifiers.org/chebi/CHEBI:34779" -end - -Ferreira_CML_generation is "Ferreira2003_CML_generation2" - -Ferreira_CML_generation model_entity_is "http://identifiers.org/biomodels.db/MODEL0733584307" -Ferreira_CML_generation model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000053" -Ferreira_CML_generation description "http://identifiers.org/pubmed/12911334" -Ferreira_CML_generation taxon "http://identifiers.org/taxonomy/131567" -Ferreira_CML_generation part "http://identifiers.org/go/GO:0018205", - "http://identifiers.org/go/GO:0005518" -Ferreira_CML_generation property "http://identifiers.org/doid/DOID:9120", - "http://identifiers.org/doid/DOID:9351" diff --git a/BioModelsRAG/data/BIOMD0000000054.txt b/BioModelsRAG/data/BIOMD0000000054.txt deleted file mode 100644 index 0d3e7de6e618667eb31032bb15f37baf9ff1a8ba..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000054.txt +++ /dev/null @@ -1,106 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Ataullahkhanov1996_Adenylate() - - // Compartments and Species: - compartment cell; - species I in cell, E in cell, A in cell; - - // Assignment Rules: - T := (A + 3*E - ((6*A*E - 3*E^2) + A^2)^0.5)/6; - M := (7*A - 3*E - ((6*A*E - 3*E^2) + A^2)^0.5)/6; - - // Reactions: - U1: => I; cell*P*J; - U2: 3 I + E => ; cell*W2*I*T; - U3: => E; cell*W3*T^0.52*M^0.41; - U6_plus_3U7: E => ; cell*2*U; - U6_plus_U7_minus_U8: => A; cell*U*(1 - W*T^n*M^k); - - // Species initializations: - I = 10; - E = 2.1; - A = 1.11; - - // Compartment initializations: - cell = 1; - - // Variable initializations: - P = 0.121; - J = 100; - W2 = 0.2; - W3 = 13.48; - U = 0.02; - W = 0.01; - n = 1.2; - k = -1; - - // Other declarations: - var T, M; - const cell, P, J, W2, W3, U, W, n, k; - - // Unit definitions: - unit substance = 1e-3 mole; - unit time_unit = 3600 second; - - // Display Names: - substance is "millimole (default)"; - time_unit is "hour (default)"; - cell is "Erythrocyte"; - I is "Ions"; - E is "Energy pool"; - A is "Adenylate pool"; - T is "ATP"; - M is "AMP"; - P is "Membrane permeability"; - J is "Extracellular ion concentration"; - W2 is "Ion pump activity"; - W3 is "Glycolytic activity"; - U is "de novo AMP synthesis"; - W is "AMP degradation"; - n is "Dependence of AMP degradation on ATP"; - k is "Dependence of AMP degradation on AMP"; - U1 is "Passive ion influx"; - U2 is "ATP consumption by ion pump"; - U3 is "ATP from glycolysis"; - U6_plus_3U7 is "AMP synthesis de novo"; - U6_plus_U7_minus_U8 is "Adenylate pool"; - - // CV terms: - cell identity "http://identifiers.org/obo.go/GO:0005623" - I identity "http://identifiers.org/obo.chebi/CHEBI:29101", - "http://identifiers.org/kegg.compound/C01330" - E version "http://identifiers.org/obo.chebi/CHEBI:15422", - "http://identifiers.org/obo.chebi/CHEBI:16761" - E version "http://identifiers.org/kegg.compound/C00008", - "http://identifiers.org/kegg.compound/C00002" - A version "http://identifiers.org/kegg.compound/C00020", - "http://identifiers.org/kegg.compound/C00008", - "http://identifiers.org/kegg.compound/C00002" - A version "http://identifiers.org/obo.chebi/CHEBI:16027", - "http://identifiers.org/obo.chebi/CHEBI:16761", - "http://identifiers.org/obo.chebi/CHEBI:15422" - U1 hypernym "http://identifiers.org/obo.go/GO:0006814" - U2 part "http://identifiers.org/obo.go/GO:0042623", - "http://identifiers.org/obo.go/GO:0006814" - U3 hypernym "http://identifiers.org/obo.go/GO:0006754" - U6_plus_3U7 part "http://identifiers.org/obo.go/GO:0003999", - "http://identifiers.org/obo.go/GO:0004001" - U6_plus_3U7 part "http://identifiers.org/ec-code/2.7.1.20", - "http://identifiers.org/ec-code/2.4.2.7" - U6_plus_U7_minus_U8 part "http://identifiers.org/ec-code/2.4.2.7", - "http://identifiers.org/ec-code/3.5.4.6", - "http://identifiers.org/ec-code/2.7.1.20" - U6_plus_U7_minus_U8 part "http://identifiers.org/obo.go/GO:0003876", - "http://identifiers.org/obo.go/GO:0004001", - "http://identifiers.org/obo.go/GO:0003999" -end - -Ataullahkhanov1996_Adenylate is "Ataullahkhanov1996_Adenylate" - -Ataullahkhanov1996_Adenylate model_entity_is "http://identifiers.org/biomodels.db/MODEL4770526315" -Ataullahkhanov1996_Adenylate model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000054" -Ataullahkhanov1996_Adenylate description "http://identifiers.org/pubmed/8733433" -Ataullahkhanov1996_Adenylate taxon "http://identifiers.org/taxonomy/9606" -Ataullahkhanov1996_Adenylate part "http://identifiers.org/obo.go/GO:0002028", - "http://identifiers.org/obo.go/GO:0006167", - "http://identifiers.org/obo.go/GO:0006110" diff --git a/BioModelsRAG/data/BIOMD0000000055.txt b/BioModelsRAG/data/BIOMD0000000055.txt deleted file mode 100644 index d18756abec1f33d03df7df9576c5d4f44ca958cf..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000055.txt +++ /dev/null @@ -1,362 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Locke2005_CircadianClock() - - // Compartments and Species: - compartment compartment_; - species cLm in compartment_, cLc in compartment_, cLn in compartment_, cTm in compartment_; - species cTc in compartment_, cTn in compartment_, cXm in compartment_, cXc in compartment_; - species cXn in compartment_, cYm in compartment_, cYc in compartment_, cYn in compartment_; - species cPn in compartment_; - - // Reactions: - one11: => cLm; compartment_*ceil(sin(pi*time/dayLength + 0.001)/2)*q1*cPn; - two11: => cLm; compartment_*(n1*cXn^a/(g1^a + cXn^a)); - three11: cLm => ; compartment_*(m1*cLm/(k1 + cLm)); - one12: => cLc; compartment_*p1*cLm; - three12: cLn => cLc; compartment_*r2*cLn; - four12: cLc => ; compartment_*(m2*cLc/(k2 + cLc)); - one13: cLc => cLn; compartment_*r1*cLc; - three13: cLn => ; compartment_*(m3*cLn/(k3 + cLn)); - one14: => cTm; compartment_*(n2*cYn^b/(g2^b + cYn^b))*(g3^c/(g3^c + cLn^c)); - two14: cTm => ; compartment_*(m4*cTm/(k4 + cTm)); - one15: => cTc; compartment_*p2*cTm; - three15: cTn => cTc; compartment_*r4*cTn; - four15: cTc => ; compartment_*((1 - ceil(sin(pi*time/dayLength + 0.001)/2))*m5 + m6)*(cTc/(k5 + cTc)); - one16: cTc => cTn; compartment_*r3*cTc; - three16: cTn => ; compartment_*((1 - ceil(sin(pi*time/dayLength + 0.001)/2))*m7 + m8)*(cTn/(k6 + cTn)); - one17: => cXm; compartment_*(n3*cTn^d/(g4^d + cTn^d)); - two17: cXm => ; compartment_*(m9*cXm/(k7 + cXm)); - one18: => cXc; compartment_*p3*cXm; - three18: cXn => cXc; compartment_*r6*cXn; - four18: cXc => ; compartment_*(m10*cXc/(k8 + cXc)); - one19: cXc => cXn; compartment_*r5*cXc; - three19: cXn => ; compartment_*(m11*cXn/(k9 + cXn)); - one20: => cYm; compartment_*(ceil(sin(pi*time/dayLength + 0.001)/2)*q2*cPn + (ceil(sin(pi*time/dayLength + 0.001)/2)*n4 + n5)*g5^e/(g5^e + cTn^e))*(g6^f/(g6^f + cLn^f)); - two20: cYm => ; compartment_*(m12*cYm/(k10 + cYm)); - one21: => cYc; compartment_*p4*cYm; - three21: cYn => cYc; compartment_*r8*cYn; - four21: cYc => ; compartment_*(m13*cYc/(k11 + cYc)); - one22: cYc => cYn; compartment_*r7*cYc; - three22: cYn => ; compartment_*(m14*cYn/(k12 + cYn)); - one23: => cPn; compartment_*(1 - ceil(sin(pi*time/dayLength + 0.001)/2))*p5; - two23: cPn => ; compartment_*(m15*cPn/(k13 + cPn)); - three23: cPn => ; compartment_*q3*ceil(sin(pi*time/dayLength + 0.001)/2)*cPn; - - // Species initializations: - cLm = 0.539; - cLc = 0.015; - cLn = 0.0855; - cTm = 0.456; - cTc = 8.7; - cTn = 0.4; - cXm = 0.08; - cXc = 1.34; - cXn = 0.4; - cYm = 0.037; - cYc = 0.004; - cYn = 0.013; - cPn = 0.835; - - // Compartment initializations: - compartment_ = 1; - - // Variable initializations: - q1 = 2.4514; - n1 = 5.1694; - a = 3.3064; - g1 = 0.876738488; - m1 = 1.5283; - k1 = 1.817; - p1 = 0.8295; - r1 = 16.8363; - r2 = 0.1687; - m2 = 20.44; - k2 = 1.5644; - m3 = 3.6888; - k3 = 1.2765; - n2 = 3.0087; - b = 1.0258; - g2 = 0.036805783; - g3 = 0.26593318; - c = 1.0258; - m4 = 3.8231; - k4 = 2.5734; - p2 = 4.324; - r3 = 0.3166; - r4 = 2.1509; - m5 = 0.0013; - m6 = 3.1741; - k5 = 2.7454; - m7 = 0.0492; - m8 = 4.0424; - k6 = 0.4033; - n3 = 0.2431; - d = 1.4422; - g4 = 0.538811228; - m9 = 10.1132; - k7 = 6.5585; - p3 = 2.147; - r5 = 1.0352; - r6 = 3.3017; - m10 = 0.2179; - k8 = 0.6632; - m11 = 3.3442; - k9 = 17.1111; - q2 = 2.40178; - n4 = 0.0857; - n5 = 0.1649; - g5 = 1.17803247; - g6 = 0.064455137; - f = 1.0237; - e = 3.6064; - m12 = 4.297; - k10 = 1.7303; - p4 = 0.2485; - r7 = 2.2123; - r8 = 0.2002; - m13 = 0.1347; - k11 = 1.8258; - m14 = 0.6114; - k12 = 1.8066; - p5 = 0.5; - k13 = 1.2; - q3 = 1; - m15 = 1.2; - Lmax = 1; - Lmin = 0; - CP = 24; - dayLength = 12; - two11_Fch_0 = 8; - four12_Fch_0 = 8; - - // Other declarations: - const compartment_, q1, n1, a, g1, m1, k1, p1, r1, r2, m2, k2, m3, k3, n2; - const b, g2, g3, c, m4, k4, p2, r3, r4, m5, m6, k5, m7, m8, k6, n3, d, g4; - const m9, k7, p3, r5, r6, m10, k8, m11, k9, q2, n4, n5, g5, g6, f, e, m12; - const k10, p4, r7, r8, m13, k11, m14, k12, p5, k13, q3, m15, Lmax, Lmin; - const CP, dayLength; - - // Unit definitions: - unit substance = 1e-9 mole; - unit time_unit = 3600 second; - - // Display Names: - substance is "nM (default)"; - time_unit is "hour (default)"; - cLm is "LHY mRNA"; - cLc is "LHY protein in cytoplasm"; - cLn is "LHY protein in nucleus"; - cTm is "TOC1 mRNA"; - cTc is "TOC1 protein in cytoplasm"; - cTn is "TOC1 protein in nucleus"; - cXm is "X mRNA"; - cXc is "X protein in cytoplasm"; - cXn is "X protein in nucleus"; - cYm is "Y mRNA"; - cYc is "Y protein in cytoplasm"; - cYn is "Y protein in nucleus"; - cPn is "light sensitive protein P"; - one11 is "LHY transcription by light activation"; - two11 is "Light independent LHY transcription"; - three11 is "LHY mRNA degradation"; - one12 is "LHY translation"; - three12 is "LHY transport out of nucleus"; - four12 is "Cytoplasmic LHY degradation"; - one13 is "LHY transport into nucleus"; - three13 is "Nuclear LHY degradation"; - one14 is "TOC1 transcription"; - two14 is "TOC mRNA degradation"; - one15 is "TOC1 translation"; - three15 is "TOC1 transport out of nucleus"; - four15 is "Cytoplasmic TOC1 degradation"; - one16 is "TOC1 movement into nucleus"; - three16 is "Nuclear TOC1 degradation"; - one17 is "Protein X transcription"; - two17 is "Protein X degradation"; - one18 is "Protein X translation"; - three18 is "ProteinX movement out of nucleus"; - four18 is "Cytoplasmic Protein X degradation"; - one19 is "Protein X movement into nucleus"; - three19 is "Nuclear Protein X degradation"; - one20 is "Protein Y transcription"; - two20 is "Protein Y mRNA degradation"; - one21 is "Protein Y translation"; - three21 is "Protein Y out of nucleus"; - four21 is "Cytoplasmic Protein Y degradation"; - one22 is "Protein Y into nucleus"; - three22 is "Nuclear Protein Y degradation"; - one23 is "Light dependent production of Protein P"; - two23 is "Protein P degradation"; - three23 is "Light activated Protein P degradation"; - - // SBO terms: - compartment_.sboTerm = 290 - cLm.sboTerm = 278 - cLc.sboTerm = 245 - cLn.sboTerm = 245 - cTm.sboTerm = 278 - cTc.sboTerm = 245 - cTn.sboTerm = 245 - cXm.sboTerm = 278 - cXc.sboTerm = 245 - cXn.sboTerm = 245 - cYm.sboTerm = 278 - cYc.sboTerm = 245 - cYn.sboTerm = 245 - cPn.sboTerm = 245 - q1.sboTerm = 337 - n1.sboTerm = 186 - a.sboTerm = 190 - g1.sboTerm = 363 - m1.sboTerm = 324 - k1.sboTerm = 27 - p1.sboTerm = 153 - r1.sboTerm = 153 - r2.sboTerm = 156 - m2.sboTerm = 324 - k2.sboTerm = 26 - m3.sboTerm = 324 - k3.sboTerm = 27 - n2.sboTerm = 186 - b.sboTerm = 190 - g2.sboTerm = 363 - g3.sboTerm = 261 - c.sboTerm = 190 - m4.sboTerm = 324 - k4.sboTerm = 27 - p2.sboTerm = 153 - r3.sboTerm = 153 - r4.sboTerm = 156 - m5.sboTerm = 324 - m6.sboTerm = 324 - k5.sboTerm = 27 - m7.sboTerm = 324 - m8.sboTerm = 324 - k6.sboTerm = 27 - n3.sboTerm = 186 - d.sboTerm = 190 - g4.sboTerm = 363 - m9.sboTerm = 324 - k7.sboTerm = 27 - p3.sboTerm = 153 - r5.sboTerm = 153 - r6.sboTerm = 156 - m10.sboTerm = 324 - k8.sboTerm = 27 - m11.sboTerm = 324 - k9.sboTerm = 27 - q2.sboTerm = 337 - n4.sboTerm = 186 - n5.sboTerm = 186 - g5.sboTerm = 261 - g6.sboTerm = 261 - f.sboTerm = 190 - e.sboTerm = 190 - m12.sboTerm = 324 - k10.sboTerm = 27 - p4.sboTerm = 153 - r7.sboTerm = 153 - r8.sboTerm = 158 - m13.sboTerm = 324 - k11.sboTerm = 27 - m14.sboTerm = 324 - k12.sboTerm = 27 - p5.sboTerm = 153 - k13.sboTerm = 27 - q3.sboTerm = 337 - m15.sboTerm = 324 - one11.sboTerm = 183 - two11.sboTerm = 183 - three11.sboTerm = 179 - one12.sboTerm = 184 - three12.sboTerm = 185 - four12.sboTerm = 179 - one13.sboTerm = 185 - three13.sboTerm = 179 - one14.sboTerm = 183 - two14.sboTerm = 179 - one15.sboTerm = 184 - three15.sboTerm = 185 - four15.sboTerm = 179 - one16.sboTerm = 185 - three16.sboTerm = 179 - one17.sboTerm = 183 - two17.sboTerm = 179 - one18.sboTerm = 184 - three18.sboTerm = 185 - four18.sboTerm = 179 - one19.sboTerm = 185 - three19.sboTerm = 179 - one20.sboTerm = 183 - two20.sboTerm = 179 - one21.sboTerm = 184 - three21.sboTerm = 185 - four21.sboTerm = 179 - one22.sboTerm = 185 - three22.sboTerm = 179 - one23.sboTerm = 393 - two23.sboTerm = 179 - three23.sboTerm = 179 - - // CV terms: - compartment_ identity "http://identifiers.org/go/GO:0005623" - cLm hypernym "http://identifiers.org/chebi/CHEBI:33699", - "http://identifiers.org/kegg.compound/C00046" - cLc identity "http://identifiers.org/uniprot/O81713" - cLn identity "http://identifiers.org/uniprot/O81713" - cTm hypernym "http://identifiers.org/chebi/CHEBI:33699", - "http://identifiers.org/kegg.compound/C00046" - cTc identity "http://identifiers.org/uniprot/Q9LKL2" - cTn identity "http://identifiers.org/uniprot/Q9LKL2" - cXm hypernym "http://identifiers.org/chebi/CHEBI:33699", - "http://identifiers.org/kegg.compound/C00046" - cXn hypernym "http://identifiers.org/go/GO:0005667" - cYm hypernym "http://identifiers.org/chebi/CHEBI:33699", - "http://identifiers.org/kegg.compound/C00046" - cYn hypernym "http://identifiers.org/go/GO:0005667" - one11 hypernym "http://identifiers.org/go/GO:0009642", - "http://identifiers.org/go/GO:0006351" - two11 hypernym "http://identifiers.org/go/GO:0006351" - three11 hypernym "http://identifiers.org/go/GO:0006402" - one12 hypernym "http://identifiers.org/go/GO:0006412" - three12 hypernym "http://identifiers.org/go/GO:0006886" - four12 hypernym "http://identifiers.org/go/GO:0030163" - one13 hypernym "http://identifiers.org/go/GO:0006886" - three13 hypernym "http://identifiers.org/go/GO:0030163" - one14 hypernym "http://identifiers.org/go/GO:0006351" - two14 hypernym "http://identifiers.org/go/GO:0006402" - one15 hypernym "http://identifiers.org/go/GO:0006412" - three15 hypernym "http://identifiers.org/go/GO:0006886" - four15 hypernym "http://identifiers.org/go/GO:0030163" - one16 hypernym "http://identifiers.org/go/GO:0006886" - three16 hypernym "http://identifiers.org/go/GO:0030163" - one17 hypernym "http://identifiers.org/go/GO:0006351" - two17 hypernym "http://identifiers.org/go/GO:0006402" - one18 hypernym "http://identifiers.org/go/GO:0006412" - three18 hypernym "http://identifiers.org/go/GO:0006886" - four18 hypernym "http://identifiers.org/go/GO:0030163" - one19 hypernym "http://identifiers.org/go/GO:0006886" - three19 hypernym "http://identifiers.org/go/GO:0030163" - one20 hypernym "http://identifiers.org/go/GO:0006351" - two20 hypernym "http://identifiers.org/go/GO:0006402" - one21 hypernym "http://identifiers.org/go/GO:0006412" - three21 hypernym "http://identifiers.org/go/GO:0006886" - four21 hypernym "http://identifiers.org/go/GO:0030163" - one22 hypernym "http://identifiers.org/go/GO:0006886" - three22 hypernym "http://identifiers.org/go/GO:0030163" - one23 hypernym "http://identifiers.org/go/GO:0009642", - "http://identifiers.org/go/GO:0006412" - two23 hypernym "http://identifiers.org/go/GO:0030163" - three23 hypernym "http://identifiers.org/go/GO:0045732", - "http://identifiers.org/go/GO:0009642" -end - -Locke2005_CircadianClock is "Locke2005 - Circadian Clock" - -Locke2005_CircadianClock model_entity_is "http://identifiers.org/biomodels.db/MODEL0737170531" -Locke2005_CircadianClock model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000055" -Locke2005_CircadianClock description "http://identifiers.org/pubmed/16729048" -Locke2005_CircadianClock origin "http://identifiers.org/pubmed/15784272" -Locke2005_CircadianClock hypernym "http://identifiers.org/go/GO:0042752" -Locke2005_CircadianClock taxon "http://identifiers.org/taxonomy/3701" -Locke2005_CircadianClock identity "http://identifiers.org/kegg.pathway/ath04710" diff --git a/BioModelsRAG/data/BIOMD0000000056.txt b/BioModelsRAG/data/BIOMD0000000056.txt deleted file mode 100644 index 0999d83633432af1880ae12ceec56bfc1f9ea177..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000056.txt +++ /dev/null @@ -1,817 +0,0 @@ -// Created by libAntimony v2.13.0 -function BB_218(A1, A2, A3, A4) - (A2 - A1) + A3*A2 + A4*A1; -end - -BB_218 is "BB" - -function GK_219(A1, A2, A3, A4) - 2*A4*A1/((A2 - A1) + A3*A2 + A4*A1 + root(2, ((A2 - A1) + A3*A2 + A4*A1)^2 - 4*(A2 - A1)*A4*A1)); -end - -GK_219 is "GK" - -function MichaelisMenten_220(M1, J1, k1, S1) - k1*S1*M1/(J1 + S1); -end - -MichaelisMenten_220 is "Michaelis-Menten" - -function Mass_Action_2_221(k1, S1, S2) - k1*S1*S2; -end - -Mass_Action_2_221 is "Mass_Action_2" - -function Mass_Action_1_222(k1, S1) - k1*S1; -end - -Mass_Action_1_222 is "Mass_Action_1" - - -model *BIOMD0000000056() - - // Compartments and Species: - compartment cell; - substanceOnly species $BCK2 in cell, MASS in cell, BUB2 in cell, BUD in cell; - substanceOnly species C2 in cell, C2P in cell, C5 in cell, C5P in cell; - substanceOnly species CDC14 in cell, $CDC14T in cell, RENT in cell, RENTP in cell; - substanceOnly species CDC15 in cell, $CDC15i in cell, CDC20 in cell, CDC20i in cell; - substanceOnly species CDC6 in cell, CDC6P in cell, $CDC6T in cell, F2 in cell; - substanceOnly species F5 in cell, F2P in cell, F5P in cell, CDH1 in cell; - substanceOnly species CDH1i in cell, $CKIT in cell, $SIC1T in cell, CLB2 in cell; - substanceOnly species $CLB2T in cell, CLB5 in cell, $CLB5T in cell, CLN2 in cell; - substanceOnly species $CLN3 in cell, ESP1 in cell, $IE in cell, IEP in cell; - substanceOnly species LTE1 in cell, MAD2 in cell, $MCM1 in cell, NET1 in cell; - substanceOnly species NET1P in cell, $NET1T in cell, ORI in cell, PDS1 in cell; - substanceOnly species $PE in cell, PPX in cell, $SBF in cell, SIC1 in cell; - substanceOnly species SIC1P in cell, SPN in cell, SWI5 in cell, SWI5P in cell; - substanceOnly species $TEM1GDP in cell, TEM1GTP in cell; - - // Assignment Rules: - BCK2 := b0*MASS; - CDC14T := CDC14 + RENT + RENTP; - CDC15i := CDC15T - CDC15; - CDC6T := CDC6 + F2 + F5 + CDC6P + F2P + F5P; - CKIT := SIC1T + CDC6T; - SIC1T := SIC1 + C2 + C5 + SIC1P + C2P + C5P; - CLB2T := CLB2 + C2 + C2P + F2 + F2P; - CLB5T := CLB5 + C5 + C5P + F5 + F5P; - CLN3 := C0*Dn3*MASS/(Jn3 + Dn3*MASS); - IE := IET - IEP; - MCM1 := GK_219(kamcm*CLB2, kimcm, Jamcm, Jimcm); - NET1T := NET1 + NET1P + RENT + RENTP; - PE := ESP1T - ESP1; - SBF := GK_219(Vasbf, Visbf, Jasbf, Jisbf); - Vasbf := kasbf*(esbfn2*CLN2 + esbfn3*(CLN3 + BCK2) + esbfb5*CLB5); - Visbf := kisbf_p + kisbf_p_p*CLB2; - TEM1GDP := TEM1T - TEM1GTP; - F := exp(-mu*D); - D := 1.026/mu - 32; - mu := ln(2)/mdt; - Vdb5 := kdb5_p + kdb5_p_p*CDC20; - Vdb2 := kdb2_p + kdb2_p_p*CDH1 + kdb2p*CDC20; - Vkpc1 := kd1c1 + Vd2c1/(Jd2c1 + SIC1 + C2 + C5 + SIC1P + C2P + C5P); - Vd2c1 := kd2c1*(ec1n3*CLN3 + ec1k2*BCK2 + ec1n2*CLN2 + ec1b5*CLB5 + ec1b2*CLB2); - Vkpf6 := kd1f6 + Vd2f6/(Jd2f6 + CDC6 + F2 + F5 + CDC6P + F2P + F5P); - Vd2f6 := kd2f6*(ef6n3*CLN3 + ef6k2*BCK2 + ef6n2*CLN2 + ef6b5*CLB5 + ef6b2*CLB2); - Vacdh := kacdh_p + kacdh_p_p*CDC14; - Vicdh := kicdh_p + kicdh_p_p*(eicdhn3*CLN3 + eicdhn2*CLN2 + eicdhb5*CLB5 + eicdhb2*CLB2); - Vppnet := kppnet_p + kppnet_p_p*PPX; - Vkpnet := (kkpnet_p + kkpnet_p_p*CDC15)*MASS; - Vdppx := kdppx_p + kdppx_p_p*(J20ppx + CDC20)*Jpds/(Jpds + PDS1); - Vdpds := kd1pds_p + kd2pds_p_p*CDC20 + kd3pds_p_p*CDH1; - Vaiep := kaiep*CLB2; - Vppc1 := kppc1*CDC14; - Vppf6 := kppf6*CDC14; - - // Reactions: - Growth: => MASS; mu*MASS; - Synthesis_of_CLN2: => CLN2; (ksn2_p + ksn2_p_p*SBF)*MASS; - Degradation_of_CLN2: CLN2 => ; Mass_Action_1_222(kdn2, CLN2); - Synthesis_of_CLB2: => CLB2; (ksb2_p + ksb2_p_p*MCM1)*MASS; - Degradation_of_CLB2: CLB2 => ; Mass_Action_1_222(Vdb2, CLB2); - Synthesis_of_CLB5: => CLB5; (ksb5_p + ksb5_p_p*SBF)*MASS; - Degradation_of_CLB5: CLB5 => ; Mass_Action_1_222(Vdb5, CLB5); - Synthesis_of_SIC1: => SIC1; ksc1_p + ksc1_p_p*SWI5; - Phosphorylation_of_SIC1: SIC1 => SIC1P; Mass_Action_1_222(Vkpc1, SIC1); - Dephosphorylation_of_SIC1: SIC1P => SIC1; Mass_Action_1_222(Vppc1, SIC1P); - Fast_Degradation_of_SIC1P: SIC1P => ; Mass_Action_1_222(kd3c1, SIC1P); - Assoc_of_CLB2_and_SIC1: CLB2 + SIC1 => C2; Mass_Action_2_221(kasb2, CLB2, SIC1); - Dissoc_of_CLB2SIC1_complex: C2 => CLB2 + SIC1; Mass_Action_1_222(kdib2, C2); - Assoc_of_CLB5_and_SIC1: CLB5 + SIC1 => C5; Mass_Action_2_221(kasb5, CLB5, SIC1); - Dissoc_of_CLB5SIC1: C5 => CLB5 + SIC1; Mass_Action_1_222(kdib5, C5); - Phosphorylation_of_C2: C2 => C2P; Mass_Action_1_222(Vkpc1, C2); - Dephosphorylation_of_C2P: C2P => C2; Mass_Action_1_222(Vppc1, C2P); - Phosphorylation_of_C5: C5 => C5P; Mass_Action_1_222(Vkpc1, C5); - Dephosphorylation_of_C5P: C5P => C5; Mass_Action_1_222(Vppc1, C5P); - Degradation_of_CLB2_in_C2: C2 => SIC1; Mass_Action_1_222(Vdb2, C2); - Degradation_of_CLB5_in_C5: C5 => SIC1; Mass_Action_1_222(Vdb5, C5); - Degradation_of_SIC1_in_C2P: C2P => CLB2; Mass_Action_1_222(kd3c1, C2P); - Degradation_of_SIC1P_in_C5P_: C5P => CLB5; Mass_Action_1_222(kd3c1, C5P); - Degradation_of_CLB2_in_C2P: C2P => SIC1P; Mass_Action_1_222(Vdb2, C2P); - Degradation_of_CLB5_in_C5P: C5P => SIC1P; Mass_Action_1_222(Vdb5, C5P); - CDC6_synthesis: => CDC6; ksf6_p + ksf6_p_p*SWI5 + ksf6_p_p_p*SBF; - Phosphorylation_of_CDC6: CDC6 => CDC6P; Mass_Action_1_222(Vkpf6, CDC6); - Dephosphorylation_of_CDC6: CDC6P => CDC6; Mass_Action_1_222(Vppf6, CDC6P); - Degradation_of_CDC6P: CDC6P => ; Mass_Action_1_222(kd3f6, CDC6P); - CLB2CDC6_complex_formation: CLB2 + CDC6 => F2; Mass_Action_2_221(kasf2, CLB2, CDC6); - CLB2CDC6_dissociation: F2 => CLB2 + CDC6; Mass_Action_1_222(kdif2, F2); - CLB5CDC6_complex_formation: CLB5 + CDC6 => F5; Mass_Action_2_221(kasf5, CLB5, CDC6); - CLB5CDC6_dissociation: F5 => CLB5 + CDC6; Mass_Action_1_222(kdif5, F5); - F2_phosphorylation: F2 => F2P; Mass_Action_1_222(Vkpf6, F2); - F2P_dephosphorylation: F2P => F2; Mass_Action_1_222(Vppf6, F2P); - F5_phosphorylation: F5 => F5P; Mass_Action_1_222(Vkpf6, F5); - F5P_dephosphorylation: F5P => F5; Mass_Action_1_222(Vppf6, F5P); - CLB2_degradation_in_F2: F2 => CDC6; Mass_Action_1_222(Vdb2, F2); - CLB5_degradation_in_F5: F5 => CDC6; Mass_Action_1_222(Vdb5, F5); - CDC6_degradation_in_F2P: F2P => CLB2; Mass_Action_1_222(kd3f6, F2P); - CDC6_degradation_in_F5P: F5P => CLB5; Mass_Action_1_222(kd3f6, F5P); - CLB2_degradation_in_F2P: F2P => CDC6P; Mass_Action_1_222(Vdb2, F2P); - CLB5_degradation_in_F5P: F5P => CDC6P; Mass_Action_1_222(Vdb5, F5P); - Synthesis_of_SWI5: => SWI5; ksswi_p + ksswi_p_p*MCM1; - Degradation_of_SWI5: SWI5 => ; Mass_Action_1_222(kdswi, SWI5); - Degradation_of_SWI5P: SWI5P => ; Mass_Action_1_222(kdswi, SWI5P); - Activation_of_SWI5: SWI5P => SWI5; Mass_Action_1_222(kaswi*CDC14, SWI5P); - Inactivation_of_SWI5: SWI5 => SWI5P; Mass_Action_1_222(kiswi*CLB2, SWI5); - Activation_of_IEP: $IE => IEP; MichaelisMenten_220(Vaiep, Jaiep, 1, IE); - Inactivation_1: IEP => $IE; MichaelisMenten_220(1, Jiiep, kiiep, IEP); - Synthesis_of_inactive_CDC20: => CDC20i; ks20_p + ks20_p_p*MCM1; - Degradation_of_inactiveCDC20: CDC20i => ; Mass_Action_1_222(kd20, CDC20i); - Degradation_of_active_CDC20: CDC20 => ; Mass_Action_1_222(kd20, CDC20); - Activation_of_CDC20: CDC20i => CDC20; Mass_Action_1_222(ka20_p + ka20_p_p*IEP, CDC20i); - Inactivation_2: CDC20 => CDC20i; Inactivation_2_k*Mass_Action_1_222(MAD2, CDC20); - CDH1_synthesis: => CDH1; kscdh; - CDH1_degradation: CDH1 => ; Mass_Action_1_222(kdcdh, CDH1); - CDH1i_degradation: CDH1i => ; Mass_Action_1_222(kdcdh, CDH1i); - CDH1i_activation: CDH1i => CDH1; MichaelisMenten_220(Vacdh, Jacdh, 1, CDH1i); - Inactivation_3: CDH1 => CDH1i; MichaelisMenten_220(Vicdh, Jicdh, 1, CDH1); - CDC14_synthesis: => CDC14; ks14; - CDC14_degradation: CDC14 => ; Mass_Action_1_222(kd14, CDC14); - Assoc_with_NET1_to_form_RENT: CDC14 + NET1 => RENT; Mass_Action_2_221(kasrent, CDC14, NET1); - Dissoc_from_RENT: RENT => NET1 + CDC14; Mass_Action_1_222(kdirent, RENT); - Assoc_with_NET1P_to_form_RENTP: CDC14 + NET1P => RENTP; Mass_Action_2_221(kasrentp, CDC14, NET1P); - Dissoc_from_RENP: RENTP => CDC14 + NET1P; Mass_Action_1_222(kdirentp, RENTP); - Net1_synthesis: => NET1; ksnet; - Net1_degradation: NET1 => ; Mass_Action_1_222(kdnet, NET1); - Net1P_degradation: NET1P => ; Mass_Action_1_222(kdnet, NET1P); - NET1_phosphorylation: NET1 => NET1P; Mass_Action_1_222(Vkpnet, NET1); - dephosphorylation_1: NET1P => NET1; Mass_Action_1_222(Vppnet, NET1P); - RENT_phosphorylation: RENT => RENTP; Mass_Action_1_222(Vkpnet, RENT); - dephosphorylation_2: RENTP => RENT; Mass_Action_1_222(Vppnet, RENTP); - Degradation_of_NET1_in_RENT: RENT => CDC14; Mass_Action_1_222(kdnet, RENT); - Degradation_of_NET1P_in_RENTP: RENTP => CDC14; Mass_Action_1_222(kdnet, RENTP); - Degradation_of_CDC14_in_RENT: RENT => NET1; Mass_Action_1_222(kd14, RENT); - Degradation_of_CDC14_in_RENTP: RENTP => NET1P; Mass_Action_1_222(kd14, RENTP); - TEM1_activation: $TEM1GDP => TEM1GTP; MichaelisMenten_220(LTE1, Jatem, 1, TEM1GDP); - inactivation_1: TEM1GTP => $TEM1GDP; MichaelisMenten_220(BUB2, Jitem, 1, TEM1GTP); - CDC15_activation: $CDC15i => CDC15; Mass_Action_1_222(ka15_p*TEM1GDP + ka15_p_p*TEM1GTP + ka15p*CDC14, CDC15i); - inactivation_2: CDC15 => $CDC15i; Mass_Action_1_222(ki15, CDC15); - PPX_synthesis: => PPX; ksppx; - degradation_1: PPX => ; Mass_Action_1_222(Vdppx, PPX); - PDS1_synthesis: => PDS1; kspds_p + ks1pds_p_p*SBF + ks2pds_p_p*MCM1; - degradation_2: PDS1 => ; Mass_Action_1_222(Vdpds, PDS1); - Degradation_of_PDS1_in_PE: $PE => ESP1; Mass_Action_1_222(Vdpds, PE); - Assoc_with_ESP1_to_form_PE: PDS1 + ESP1 => $PE; Mass_Action_2_221(kasesp, PDS1, ESP1); - Disso_from_PE: $PE => PDS1 + ESP1; Mass_Action_1_222(kdiesp, PE); - DNA_synthesis: => ORI; ksori*(eorib5*CLB5 + eorib2*CLB2); - Negative_regulation_of_DNA_synthesis: ORI => ; Mass_Action_1_222(kdori, ORI); - Budding: => BUD; ksbud*(ebudn2*CLN2 + ebudn3*CLN3 + ebudb5*CLB5); - Negative_regulation_of_Cell_budding: BUD => ; Mass_Action_1_222(kdbud, BUD); - Spindle_formation: => SPN; ksspn*CLB2/(Jspn + CLB2); - Spindle_disassembly: SPN => ; Mass_Action_1_222(kdspn, SPN); - - // Events: - reset_ORI: at (CLB2 + CLB5 - KEZ2) < 0: ORI = 0; - start_S: at (ORI - 1) > 0: BUB2 = bub2h, MAD2 = mad2h; - spindle_checkpoint: at (SPN - 1) > 0: BUB2 = bub2l, LTE1 = lte1h, MAD2 = mad2l; - cell_division: at (CLB2 - KEZ) < 0: SPN = 0, BUD = 0, LTE1 = lte1l, MASS = F*MASS; - - // Species initializations: - MASS = 1.206019/cell; - BUB2 = 0.2/cell; - BUD = 0.008473/cell; - C2 = 0.238404/cell; - C2P = 0.024034/cell; - C5 = 0.070081/cell; - C5P = 0.006878/cell; - CDC14 = 0.468344/cell; - RENT = 1.04954/cell; - RENTP = 0.6/cell; - CDC15 = 0.656533/cell; - CDC20 = 0.444296/cell; - CDC20i = 1.472044/cell; - CDC6 = 0.10758/cell; - CDC6P = 0.015486/cell; - F2 = 0.236058/cell; - F5 = 7.24e-05/cell; - F2P = 0.0273938/cell; - F5P = 7.91e-05/cell; - CDH1 = 0.930499/cell; - CDH1i = 0.0695/cell; - CLB2 = 0.1469227/cell; - CLB5 = 0.0518014/cell; - CLN2 = 0.0652511/cell; - ESP1 = 0.301313/cell; - IEP = 0.1015/cell; - LTE1 = 0.1/cell; - MAD2 = 0.01/cell; - NET1 = 0.018645/cell; - NET1P = 0.970271/cell; - ORI = 0.000909/cell; - PDS1 = 0.025612/cell; - PPX = 0.123179/cell; - SIC1 = 0.0228776/cell; - SIC1P = 0.00641/cell; - SPN = 0.03/cell; - SWI5 = 0.95/cell; - SWI5P = 0.02/cell; - TEM1GTP = 0.9/cell; - - // Compartment initializations: - cell = 1; - - // Variable initializations: - b0 = 0.054; - CDC15T = 1; - C0 = 0.4; - Dn3 = 1; - Jn3 = 6; - IET = 1; - kamcm = 1; - kimcm = 0.15; - Jamcm = 0.1; - Jimcm = 0.1; - ESP1T = 1; - Jasbf = 0.01; - Jisbf = 0.01; - TEM1T = 1; - KEZ2 = 0.2; - mad2h = 8; - bub2h = 1; - mad2l = 0.01; - lte1h = 1; - bub2l = 0.2; - KEZ = 0.3; - lte1l = 0.1; - ebudb5 = 1; - ebudn2 = 0.25; - ebudn3 = 0.05; - ec1b2 = 0.45; - ec1b5 = 0.1; - ec1k2 = 0.03; - ec1n2 = 0.06; - ec1n3 = 0.3; - ef6b2 = 0.55; - ef6b5 = 0.1; - ef6k2 = 0.03; - ef6n2 = 0.06; - ef6n3 = 0.3; - eicdhb2 = 1.2; - eicdhb5 = 8; - eicdhn2 = 0.4; - eicdhn3 = 0.25; - eorib2 = 0.45; - eorib5 = 0.9; - esbfb5 = 2; - esbfn2 = 2; - esbfn3 = 10; - J20ppx = 0.15; - Jacdh = 0.03; - Jaiep = 0.1; - Jatem = 0.1; - Jd2c1 = 0.05; - Jd2f6 = 0.05; - Jicdh = 0.03; - Jiiep = 0.1; - Jitem = 0.1; - Jpds = 0.04; - Jspn = 0.14; - ka15_p = 0.002; - ka15_p_p = 1; - ka15p = 0.001; - ka20_p = 0.05; - ka20_p_p = 0.2; - kacdh_p = 0.01; - kacdh_p_p = 0.8; - kaiep = 0.1; - kasb2 = 50; - kasb5 = 50; - kasbf = 0.38; - kasesp = 50; - kasf2 = 15; - kasf5 = 0.01; - kasrent = 200; - kasrentp = 1; - kaswi = 2; - kd14 = 0.1; - kd1c1 = 0.01; - kd1f6 = 0.01; - kd1pds_p = 0.01; - kd20 = 0.3; - kd2c1 = 1; - kd2f6 = 1; - kd2pds_p_p = 0.2; - kd3c1 = 1; - kd3f6 = 1; - kd3pds_p_p = 0.04; - kdb2_p = 0.003; - kdb2_p_p = 0.4; - kdb2p = 0.15; - kdb5_p = 0.01; - kdb5_p_p = 0.16; - kdbud = 0.06; - kdcdh = 0.01; - kdib2 = 0.05; - kdib5 = 0.06; - kdiesp = 0.5; - kdif2 = 0.5; - kdif5 = 0.01; - kdirent = 1; - kdirentp = 2; - kdn2 = 0.12; - kdnet = 0.03; - kdori = 0.06; - kdppx_p = 0.17; - kdppx_p_p = 2; - kdspn = 0.06; - kdswi = 0.08; - ki15 = 0.5; - kicdh_p = 0.001; - kicdh_p_p = 0.08; - kiiep = 0.15; - kisbf_p = 0.6; - kisbf_p_p = 8; - kiswi = 0.05; - kkpnet_p = 0.01; - kkpnet_p_p = 0.6; - kppc1 = 4; - kppf6 = 4; - kppnet_p = 0.05; - kppnet_p_p = 3; - ks14 = 0.2; - ks1pds_p_p = 0.03; - ks20_p = 0.006; - ks20_p_p = 0.6; - ks2pds_p_p = 0.055; - ksb2_p = 0.001; - ksb2_p_p = 0.04; - ksb5_p = 0.0008; - ksb5_p_p = 0.005; - ksbud = 0.2; - ksc1_p = 0.012; - ksc1_p_p = 0.12; - kscdh = 0.01; - ksf6_p = 0.024; - ksf6_p_p = 0.12; - ksf6_p_p_p = 0.004; - ksn2_p = 0; - ksn2_p_p = 0.15; - ksnet = 0.084; - ksori = 2; - kspds_p = 0; - ksppx = 0.1; - ksspn = 0.1; - ksswi_p = 0.005; - ksswi_p_p = 0.08; - mdt = 90; - Inactivation_2_k = 1; - - // Other declarations: - var CDC15T, IET, ESP1T, Vasbf, Visbf, TEM1T, KEZ2, mad2l, lte1h, bub2l; - var KEZ, F, lte1l, D, mu, Vdb5, Vdb2, Vkpc1, Vd2c1, Vkpf6, Vd2f6, Vacdh; - var Vicdh, Vppnet, Vkpnet, Vdppx, Vdpds, Vaiep, Vppc1, Vppf6; - const cell, b0, C0, Dn3, Jn3, kamcm, kimcm, Jamcm, Jimcm, Jasbf, Jisbf; - const mad2h, bub2h, ebudb5, ebudn2, ebudn3, ec1b2, ec1b5, ec1k2, ec1n2; - const ec1n3, ef6b2, ef6b5, ef6k2, ef6n2, ef6n3, eicdhb2, eicdhb5, eicdhn2; - const eicdhn3, eorib2, eorib5, esbfb5, esbfn2, esbfn3, J20ppx, Jacdh, Jaiep; - const Jatem, Jd2c1, Jd2f6, Jicdh, Jiiep, Jitem, Jpds, Jspn, ka15_p, ka15_p_p; - const ka15p, ka20_p, ka20_p_p, kacdh_p, kacdh_p_p, kaiep, kasb2, kasb5; - const kasbf, kasesp, kasf2, kasf5, kasrent, kasrentp, kaswi, kd14, kd1c1; - const kd1f6, kd1pds_p, kd20, kd2c1, kd2f6, kd2pds_p_p, kd3c1, kd3f6, kd3pds_p_p; - const kdb2_p, kdb2_p_p, kdb2p, kdb5_p, kdb5_p_p, kdbud, kdcdh, kdib2, kdib5; - const kdiesp, kdif2, kdif5, kdirent, kdirentp, kdn2, kdnet, kdori, kdppx_p; - const kdppx_p_p, kdspn, kdswi, ki15, kicdh_p, kicdh_p_p, kiiep, kisbf_p; - const kisbf_p_p, kiswi, kkpnet_p, kkpnet_p_p, kppc1, kppf6, kppnet_p, kppnet_p_p; - const ks14, ks1pds_p_p, ks20_p, ks20_p_p, ks2pds_p_p, ksb2_p, ksb2_p_p; - const ksb5_p, ksb5_p_p, ksbud, ksc1_p, ksc1_p_p, kscdh, ksf6_p, ksf6_p_p; - const ksf6_p_p_p, ksn2_p, ksn2_p_p, ksnet, ksori, kspds_p, ksppx, ksspn; - const ksswi_p, ksswi_p_p, mdt; - - // Unit definitions: - unit time_unit = 60 second; - - // Display Names: - time_unit is "min"; - reset_ORI is "reset ORI"; - start_S is "start DNA synthesis"; - spindle_checkpoint is "spindle checkpoint"; - cell_division is "cell division"; - ka15_p is "ka15'"; - ka15_p_p is "ka15''"; - ka20_p is "ka20'"; - ka20_p_p is "ka20''"; - kacdh_p is "kacdh'"; - kacdh_p_p is "kacdh''"; - kd1pds_p is "kd1pds'"; - kd2pds_p_p is "kd2pds''"; - kd3pds_p_p is "kd3pds''"; - kdb2_p is "kdb2'"; - kdb2_p_p is "kdb2''"; - kdb5_p is "kdb5'"; - kdb5_p_p is "kdb5''"; - kdppx_p is "kdppx'"; - kdppx_p_p is "kdppx''"; - kicdh_p is "kicdh'"; - kicdh_p_p is "kicdh''"; - kisbf_p is "kisbf'"; - kisbf_p_p is "kisbf''"; - kkpnet_p is "kkpnet'"; - kkpnet_p_p is "kkpnet''"; - kppnet_p is "kppnet'"; - kppnet_p_p is "kppnet''"; - ks1pds_p_p is "ks1pds''"; - ks20_p is "ks20'"; - ks20_p_p is "ks20''"; - ks2pds_p_p is "ks2pds''"; - ksb2_p is "ksb2'"; - ksb2_p_p is "ksb2''"; - ksb5_p is "ksb5'"; - ksb5_p_p is "ksb5''"; - ksc1_p is "ksc1'"; - ksc1_p_p is "ksc1''"; - ksf6_p is "ksf6'"; - ksf6_p_p is "ksf6''"; - ksf6_p_p_p is "ksf6'''"; - ksn2_p is "ksn2'"; - ksn2_p_p is "ksn2''"; - kspds_p is "kspds'"; - ksswi_p is "ksswi'"; - ksswi_p_p is "ksswi''"; - Synthesis_of_CLN2 is "Synthesis of CLN2"; - Degradation_of_CLN2 is "Degradation of CLN2"; - Synthesis_of_CLB2 is "Synthesis of CLB2"; - Degradation_of_CLB2 is "Degradation of CLB2"; - Synthesis_of_CLB5 is "Synthesis of CLB5"; - Degradation_of_CLB5 is "Degradation of CLB5"; - Synthesis_of_SIC1 is "Synthesis of SIC1"; - Phosphorylation_of_SIC1 is "Phosphorylation of SIC1"; - Dephosphorylation_of_SIC1 is "Dephosphorylation of SIC1"; - Fast_Degradation_of_SIC1P is "Fast Degradation of SIC1P"; - Assoc_of_CLB2_and_SIC1 is "Assoc. of CLB2 and SIC1"; - Dissoc_of_CLB2SIC1_complex is "Dissoc. of CLB2/SIC1 complex"; - Assoc_of_CLB5_and_SIC1 is "Assoc. of CLB5 and SIC1"; - Dissoc_of_CLB5SIC1 is "Dissoc. of CLB5/SIC1"; - Phosphorylation_of_C2 is "Phosphorylation of C2"; - Dephosphorylation_of_C2P is "Dephosphorylation of C2P"; - Phosphorylation_of_C5 is "Phosphorylation of C5"; - Dephosphorylation_of_C5P is "Dephosphorylation of C5P"; - Degradation_of_CLB2_in_C2 is "Degradation of CLB2 in C2"; - Degradation_of_CLB5_in_C5 is "Degradation of CLB5 in C5"; - Degradation_of_SIC1_in_C2P is "Degradation of SIC1 in C2P"; - Degradation_of_SIC1P_in_C5P_ is "Degradation of SIC1P in C5P"; - Degradation_of_CLB2_in_C2P is "Degradation of CLB2 in C2P"; - Degradation_of_CLB5_in_C5P is "Degradation of CLB5 in C5P"; - CDC6_synthesis is "CDC6 synthesis"; - Phosphorylation_of_CDC6 is "Phosphorylation of CDC6"; - Dephosphorylation_of_CDC6 is "Dephosphorylation of CDC6"; - Degradation_of_CDC6P is "Degradation of CDC6P"; - CLB2CDC6_complex_formation is "CLB2/CDC6 complex formation"; - CLB2CDC6_dissociation is "CLB2/CDC6 dissociation"; - CLB5CDC6_complex_formation is "CLB5/CDC6 complex formation"; - CLB5CDC6_dissociation is "CLB5/CDC6 dissociation"; - F2_phosphorylation is "F2 phosphorylation"; - F2P_dephosphorylation is "F2P dephosphorylation"; - F5_phosphorylation is "F5 phosphorylation"; - F5P_dephosphorylation is "F5P dephosphorylation"; - CLB2_degradation_in_F2 is "CLB2 degradation in F2"; - CLB5_degradation_in_F5 is "CLB5 degradation in F5"; - CDC6_degradation_in_F2P is "CDC6 degradation in F2P"; - CDC6_degradation_in_F5P is "CDC6 degradation in F5P"; - CLB2_degradation_in_F2P is "CLB2 degradation in F2P"; - CLB5_degradation_in_F5P is "CLB5 degradation in F5P"; - Synthesis_of_SWI5 is "Synthesis of SWI5"; - Degradation_of_SWI5 is "Degradation of SWI5"; - Degradation_of_SWI5P is "Degradation of SWI5P"; - Activation_of_SWI5 is "Activation of SWI5"; - Inactivation_of_SWI5 is "Inactivation of SWI5"; - Activation_of_IEP is "Activation of IEP"; - Inactivation_1 is "Inactivation"; - Synthesis_of_inactive_CDC20 is "Synthesis of inactive CDC20"; - Degradation_of_inactiveCDC20 is "Degradation of inactiveCDC20"; - Degradation_of_active_CDC20 is "Degradation of active CDC20"; - Activation_of_CDC20 is "Activation of CDC20"; - Inactivation_2 is "Inactivation"; - CDH1_synthesis is "CDH1 synthesis"; - CDH1_degradation is "CDH1 degradation"; - CDH1i_degradation is "CDH1i degradation"; - CDH1i_activation is "CDH1i activation"; - Inactivation_3 is "Inactivation"; - CDC14_synthesis is "CDC14 synthesis"; - CDC14_degradation is "CDC14 degradation"; - Assoc_with_NET1_to_form_RENT is "Assoc. with NET1 to form RENT"; - Dissoc_from_RENT is "Dissoc. from RENT"; - Assoc_with_NET1P_to_form_RENTP is "Assoc with NET1P to form RENTP"; - Dissoc_from_RENP is "Dissoc. from RENP"; - Net1_synthesis is "Net1 synthesis"; - Net1_degradation is "Net1 degradation"; - Net1P_degradation is "Net1P degradation"; - NET1_phosphorylation is "NET1 phosphorylation"; - dephosphorylation_1 is "dephosphorylation"; - RENT_phosphorylation is "RENT phosphorylation"; - dephosphorylation_2 is "dephosphorylation"; - Degradation_of_NET1_in_RENT is "Degradation of NET1 in RENT"; - Degradation_of_NET1P_in_RENTP is "Degradation of NET1P in RENTP"; - Degradation_of_CDC14_in_RENT is "Degradation of CDC14 in RENT"; - Degradation_of_CDC14_in_RENTP is "Degradation of CDC14 in RENTP"; - TEM1_activation is "TEM1 activation"; - inactivation_1 is "inactivation"; - CDC15_activation is "CDC15 activation"; - inactivation_2 is "inactivation"; - PPX_synthesis is "PPX synthesis"; - degradation_1 is "degradation"; - PDS1_synthesis is "PDS1 synthesis"; - degradation_2 is "degradation"; - Degradation_of_PDS1_in_PE is "Degradation of PDS1 in PE"; - Assoc_with_ESP1_to_form_PE is "Assoc. with ESP1 to form PE"; - Disso_from_PE is "Disso. from PE"; - DNA_synthesis is "DNA synthesis"; - Negative_regulation_of_DNA_synthesis is "Negative regulation of DNA synthesis"; - Negative_regulation_of_Cell_budding is "Negative regulation of Cell budding"; - Spindle_formation is "Spindle formation"; - Spindle_disassembly is "Spindle disassembly"; - - // CV terms: - cell hypernym "http://identifiers.org/obo.go/GO:0005623" - BCK2 identity "http://identifiers.org/uniprot/P33306" - MASS hypernym "http://identifiers.org/obo.fma/FMA:86557" - BUB2 identity "http://identifiers.org/uniprot/P26448" - BUD hypernym "http://identifiers.org/cco/CCO:C0000485" - C2 part "http://identifiers.org/uniprot/P38634", - "http://identifiers.org/uniprot/P24869", - "http://identifiers.org/uniprot/P24868" - C2P part "http://identifiers.org/uniprot/P24868", - "http://identifiers.org/uniprot/P24869", - "http://identifiers.org/uniprot/P38634" - C5 part "http://identifiers.org/uniprot/P38634", - "http://identifiers.org/uniprot/P32943", - "http://identifiers.org/uniprot/P30283" - C5P part "http://identifiers.org/uniprot/P38634", - "http://identifiers.org/uniprot/P32943", - "http://identifiers.org/uniprot/P30283" - CDC14 identity "http://identifiers.org/uniprot/Q00684" - CDC14T identity "http://identifiers.org/uniprot/Q00684" - RENT identity "http://identifiers.org/obo.go/GO:0030869" - RENT part "http://identifiers.org/uniprot/P47035", - "http://identifiers.org/uniprot/P06700", - "http://identifiers.org/uniprot/Q00684" - RENTP identity "http://identifiers.org/obo.go/GO:0030869" - RENTP part "http://identifiers.org/uniprot/P06700", - "http://identifiers.org/uniprot/P47035", - "http://identifiers.org/uniprot/Q00684" - CDC15 identity "http://identifiers.org/uniprot/P27636" - CDC15i identity "http://identifiers.org/uniprot/P27636" - CDC20 identity "http://identifiers.org/uniprot/P26309" - CDC20i identity "http://identifiers.org/uniprot/P26309" - CDC6 identity "http://identifiers.org/uniprot/P09119" - CDC6P identity "http://identifiers.org/uniprot/P09119" - CDC6T identity "http://identifiers.org/uniprot/P09119" - F2 part "http://identifiers.org/uniprot/P09119", - "http://identifiers.org/uniprot/P24868", - "http://identifiers.org/uniprot/P24869" - F5 part "http://identifiers.org/uniprot/P32943", - "http://identifiers.org/uniprot/P30283", - "http://identifiers.org/uniprot/P09119" - F2P part "http://identifiers.org/uniprot/P09119", - "http://identifiers.org/uniprot/P24868", - "http://identifiers.org/uniprot/P24869" - F5P part "http://identifiers.org/uniprot/P09119", - "http://identifiers.org/uniprot/P30283", - "http://identifiers.org/uniprot/P32943" - CDH1 identity "http://identifiers.org/uniprot/P53197" - CDH1i identity "http://identifiers.org/uniprot/P53197" - CKIT part "http://identifiers.org/uniprot/P38634", - "http://identifiers.org/uniprot/P09119" - SIC1T identity "http://identifiers.org/uniprot/P38634" - CLB2 part "http://identifiers.org/uniprot/P24869", - "http://identifiers.org/uniprot/P24868" - CLB2T part "http://identifiers.org/uniprot/P24869", - "http://identifiers.org/uniprot/P24868" - CLB5 part "http://identifiers.org/uniprot/P32943", - "http://identifiers.org/uniprot/P30283" - CLB5T part "http://identifiers.org/uniprot/P32943", - "http://identifiers.org/uniprot/P30283" - CLN2 part "http://identifiers.org/uniprot/P20438", - "http://identifiers.org/uniprot/P20437" - CLN3 identity "http://identifiers.org/uniprot/P13365" - ESP1 identity "http://identifiers.org/uniprot/Q03018" - IE identity "http://identifiers.org/obo.go/GO:0005680" - IEP identity "http://identifiers.org/obo.go/GO:0005680" - LTE1 identity "http://identifiers.org/uniprot/P07866" - MAD2 identity "http://identifiers.org/uniprot/P40958" - MCM1 identity "http://identifiers.org/uniprot/P11746" - NET1 identity "http://identifiers.org/uniprot/P47035" - NET1P identity "http://identifiers.org/uniprot/P47035" - NET1T identity "http://identifiers.org/uniprot/P47035" - PDS1 identity "http://identifiers.org/uniprot/P40316" - PE identity "http://identifiers.org/uniprot/Q03018" - PPX identity "http://identifiers.org/uniprot/P38698" - SBF identity "http://identifiers.org/uniprot/P11938" - SIC1 identity "http://identifiers.org/uniprot/P38634" - SIC1P identity "http://identifiers.org/uniprot/P38634" - SPN hypernym "http://identifiers.org/cco/CCO:P0000392" - SWI5 identity "http://identifiers.org/uniprot/P08153" - SWI5P identity "http://identifiers.org/uniprot/P08153" - TEM1GDP identity "http://identifiers.org/uniprot/P38987" - TEM1GTP identity "http://identifiers.org/uniprot/P38987" - Growth hypernym "http://identifiers.org/obo.go/GO:0016049" - Synthesis_of_CLN2 hypernym "http://identifiers.org/kegg.pathway/sce04110", - "http://identifiers.org/obo.go/GO:0006412" - Degradation_of_CLN2 hypernym "http://identifiers.org/obo.go/GO:0008054" - Synthesis_of_CLB2 hypernym "http://identifiers.org/obo.go/GO:0006412" - Degradation_of_CLB2 hypernym "http://identifiers.org/obo.go/GO:0051437", - "http://identifiers.org/obo.go/GO:0008054" - Synthesis_of_CLB5 hypernym "http://identifiers.org/obo.go/GO:0006412" - Degradation_of_CLB5 hypernym "http://identifiers.org/obo.go/GO:0008054", - "http://identifiers.org/obo.go/GO:0051437" - Synthesis_of_SIC1 hypernym "http://identifiers.org/obo.go/GO:0006412" - Phosphorylation_of_SIC1 hypernym "http://identifiers.org/ec-code/2.7.11.22", - "http://identifiers.org/obo.go/GO:0004693", - "http://identifiers.org/obo.go/GO:0006468" - Dephosphorylation_of_SIC1 hypernym "http://identifiers.org/ec-code/3.1.3.48", - "http://identifiers.org/obo.go/GO:0004721", - "http://identifiers.org/obo.go/GO:0006470" - Fast_Degradation_of_SIC1P hypernym "http://identifiers.org/obo.go/GO:0030163" - Assoc_of_CLB2_and_SIC1 hypernym "http://identifiers.org/obo.go/GO:0005515", - "http://identifiers.org/obo.go/GO:0043623" - Dissoc_of_CLB2SIC1_complex hypernym "http://identifiers.org/obo.go/GO:0043624" - Assoc_of_CLB5_and_SIC1 hypernym "http://identifiers.org/obo.go/GO:0043623", - "http://identifiers.org/obo.go/GO:0005515" - Dissoc_of_CLB5SIC1 hypernym "http://identifiers.org/obo.go/GO:0043624" - Phosphorylation_of_C2 hypernym "http://identifiers.org/ec-code/2.7.11.22", - "http://identifiers.org/obo.go/GO:0006468", - "http://identifiers.org/obo.go/GO:0004693" - Dephosphorylation_of_C2P hypernym "http://identifiers.org/ec-code/3.1.3.48", - "http://identifiers.org/obo.go/GO:0006470", - "http://identifiers.org/obo.go/GO:0004721" - Phosphorylation_of_C5 hypernym "http://identifiers.org/ec-code/2.7.11.22", - "http://identifiers.org/obo.go/GO:0006468", - "http://identifiers.org/obo.go/GO:0004693" - Dephosphorylation_of_C5P hypernym "http://identifiers.org/ec-code/3.1.3.48", - "http://identifiers.org/obo.go/GO:0006470", - "http://identifiers.org/obo.go/GO:0004721" - Degradation_of_CLB2_in_C2 hypernym "http://identifiers.org/obo.go/GO:0051437", - "http://identifiers.org/obo.go/GO:0008054" - Degradation_of_CLB5_in_C5 hypernym "http://identifiers.org/obo.go/GO:0008054", - "http://identifiers.org/obo.go/GO:0051437" - Degradation_of_SIC1_in_C2P hypernym "http://identifiers.org/obo.go/GO:0030163" - Degradation_of_SIC1P_in_C5P_ hypernym "http://identifiers.org/obo.go/GO:0030163" - Degradation_of_CLB2_in_C2P hypernym "http://identifiers.org/obo.go/GO:0051437", - "http://identifiers.org/obo.go/GO:0008054" - Degradation_of_CLB5_in_C5P hypernym "http://identifiers.org/obo.go/GO:0051437", - "http://identifiers.org/obo.go/GO:0008054" - CDC6_synthesis hypernym "http://identifiers.org/obo.go/GO:0006412" - Phosphorylation_of_CDC6 hypernym "http://identifiers.org/ec-code/2.7.11.22", - "http://identifiers.org/obo.go/GO:0004693", - "http://identifiers.org/obo.go/GO:0006468" - Dephosphorylation_of_CDC6 hypernym "http://identifiers.org/ec-code/3.1.3.48", - "http://identifiers.org/obo.go/GO:0004721", - "http://identifiers.org/obo.go/GO:0006470" - Degradation_of_CDC6P hypernym "http://identifiers.org/obo.go/GO:0030163" - CLB2CDC6_complex_formation hypernym "http://identifiers.org/obo.go/GO:0043623", - "http://identifiers.org/obo.go/GO:0005515" - CLB2CDC6_dissociation hypernym "http://identifiers.org/obo.go/GO:0043624" - CLB5CDC6_complex_formation hypernym "http://identifiers.org/obo.go/GO:0043623", - "http://identifiers.org/obo.go/GO:0005515" - CLB5CDC6_dissociation hypernym "http://identifiers.org/obo.go/GO:0043624" - F2_phosphorylation hypernym "http://identifiers.org/ec-code/2.7.11.22", - "http://identifiers.org/obo.go/GO:0006468", - "http://identifiers.org/obo.go/GO:0004693" - F2P_dephosphorylation hypernym "http://identifiers.org/ec-code/3.1.3.48", - "http://identifiers.org/obo.go/GO:0006470", - "http://identifiers.org/obo.go/GO:0004721" - F5_phosphorylation hypernym "http://identifiers.org/ec-code/2.7.11.22", - "http://identifiers.org/obo.go/GO:0006468", - "http://identifiers.org/obo.go/GO:0004693" - F5P_dephosphorylation hypernym "http://identifiers.org/ec-code/3.1.3.48", - "http://identifiers.org/obo.go/GO:0006470", - "http://identifiers.org/obo.go/GO:0004721" - CLB2_degradation_in_F2 hypernym "http://identifiers.org/obo.go/GO:0051437", - "http://identifiers.org/obo.go/GO:0008054" - CLB5_degradation_in_F5 hypernym "http://identifiers.org/obo.go/GO:0051437", - "http://identifiers.org/obo.go/GO:0008054" - CDC6_degradation_in_F2P hypernym "http://identifiers.org/obo.go/GO:0030163" - CDC6_degradation_in_F5P hypernym "http://identifiers.org/obo.go/GO:0030163" - CLB2_degradation_in_F2P hypernym "http://identifiers.org/obo.go/GO:0051437", - "http://identifiers.org/obo.go/GO:0008054" - CLB5_degradation_in_F5P hypernym "http://identifiers.org/obo.go/GO:0051437", - "http://identifiers.org/obo.go/GO:0008054" - Synthesis_of_SWI5 hypernym "http://identifiers.org/obo.go/GO:0006412" - Degradation_of_SWI5 hypernym "http://identifiers.org/obo.go/GO:0030163" - Degradation_of_SWI5P hypernym "http://identifiers.org/obo.go/GO:0030163" - Activation_of_SWI5 hypernym "http://identifiers.org/ec-code/3.1.3.48", - "http://identifiers.org/obo.go/GO:0006470", - "http://identifiers.org/obo.go/GO:0051091", - "http://identifiers.org/obo.go/GO:0004721" - Inactivation_of_SWI5 hypernym "http://identifiers.org/ec-code/2.7.11.22", - "http://identifiers.org/obo.go/GO:0006468", - "http://identifiers.org/obo.go/GO:0004693", - "http://identifiers.org/obo.go/GO:0043433" - Activation_of_IEP hypernym "http://identifiers.org/ec-code/2.7.11.22", - "http://identifiers.org/obo.go/GO:0006468", - "http://identifiers.org/obo.go/GO:0004693" - Inactivation_1 hypernym "http://identifiers.org/obo.go/GO:0001100", - "http://identifiers.org/obo.go/GO:0006470" - Synthesis_of_inactive_CDC20 hypernym "http://identifiers.org/obo.go/GO:0006412" - Degradation_of_inactiveCDC20 hypernym "http://identifiers.org/obo.go/GO:0030163" - Degradation_of_active_CDC20 hypernym "http://identifiers.org/obo.go/GO:0030163" - Activation_of_CDC20 hypernym "http://identifiers.org/obo.go/GO:0031536" - Inactivation_2 hypernym "http://identifiers.org/obo.go/GO:0001100" - CDH1_synthesis hypernym "http://identifiers.org/obo.go/GO:0006412" - CDH1_degradation hypernym "http://identifiers.org/obo.go/GO:0030163" - CDH1i_degradation hypernym "http://identifiers.org/obo.go/GO:0030163" - CDH1i_activation hypernym "http://identifiers.org/ec-code/3.1.3.48", - "http://identifiers.org/obo.go/GO:0004721", - "http://identifiers.org/obo.go/GO:0006470", - "http://identifiers.org/obo.go/GO:0031536" - Inactivation_3 hypernym "http://identifiers.org/ec-code/2.7.11.22", - "http://identifiers.org/obo.go/GO:0004693", - "http://identifiers.org/obo.go/GO:0001100", - "http://identifiers.org/obo.go/GO:0006468" - CDC14_synthesis hypernym "http://identifiers.org/obo.go/GO:0006412" - CDC14_degradation hypernym "http://identifiers.org/obo.go/GO:0030163" - Assoc_with_NET1_to_form_RENT hypernym "http://identifiers.org/obo.go/GO:0030869", - "http://identifiers.org/obo.go/GO:0005515", - "http://identifiers.org/obo.go/GO:0043623" - Dissoc_from_RENT hypernym "http://identifiers.org/obo.go/GO:0043624" - Assoc_with_NET1P_to_form_RENTP part "http://identifiers.org/kegg.pathway/ko04111" - Assoc_with_NET1P_to_form_RENTP hypernym "http://identifiers.org/obo.go/GO:0043623", - "http://identifiers.org/obo.go/GO:0005515" - Dissoc_from_RENP hypernym "http://identifiers.org/obo.go/GO:0043624" - Net1_synthesis hypernym "http://identifiers.org/obo.go/GO:0006412" - Net1_degradation hypernym "http://identifiers.org/obo.go/GO:0030163" - Net1P_degradation hypernym "http://identifiers.org/obo.go/GO:0030163" - NET1_phosphorylation hypernym "http://identifiers.org/ec-code/2.7.11.1", - "http://identifiers.org/obo.go/GO:0004672", - "http://identifiers.org/obo.go/GO:0006468", - "http://identifiers.org/obo.go/GO:0031536" - dephosphorylation_1 hypernym "http://identifiers.org/ec-code/3.6.1.11", - "http://identifiers.org/obo.go/GO:0004309", - "http://identifiers.org/obo.go/GO:0006470" - RENT_phosphorylation hypernym "http://identifiers.org/ec-code/2.7.11.1", - "http://identifiers.org/obo.go/GO:0031536", - "http://identifiers.org/obo.go/GO:0006468", - "http://identifiers.org/obo.go/GO:0004672" - dephosphorylation_2 hypernym "http://identifiers.org/ec-code/3.6.1.11", - "http://identifiers.org/obo.go/GO:0006470", - "http://identifiers.org/obo.go/GO:0004309" - Degradation_of_NET1_in_RENT hypernym "http://identifiers.org/obo.go/GO:0030163" - Degradation_of_NET1P_in_RENTP hypernym "http://identifiers.org/obo.go/GO:0030163" - Degradation_of_CDC14_in_RENT hypernym "http://identifiers.org/obo.go/GO:0030163" - Degradation_of_CDC14_in_RENTP hypernym "http://identifiers.org/obo.go/GO:0030163" - TEM1_activation hypernym "http://identifiers.org/obo.go/GO:0005525", - "http://identifiers.org/obo.go/GO:0031536", - "http://identifiers.org/obo.go/GO:0005515" - inactivation_1 hypernym "http://identifiers.org/obo.go/GO:0005096", - "http://identifiers.org/obo.go/GO:0007094", - "http://identifiers.org/obo.go/GO:0005515" - CDC15_activation hypernym "http://identifiers.org/ec-code/2.7.11.1", - "http://identifiers.org/ec-code/3.1.3.48", - "http://identifiers.org/obo.go/GO:0004721", - "http://identifiers.org/obo.go/GO:0031536", - "http://identifiers.org/obo.go/GO:0006470" - inactivation_2 hypernym "http://identifiers.org/ec-code/2.7.11.1", - "http://identifiers.org/obo.go/GO:0006469", - "http://identifiers.org/obo.go/GO:0001100" - PPX_synthesis hypernym "http://identifiers.org/ec-code/3.6.1.11", - "http://identifiers.org/obo.go/GO:0006412" - degradation_1 hypernym "http://identifiers.org/obo.go/GO:0030163" - PDS1_synthesis hypernym "http://identifiers.org/obo.go/GO:0006412" - degradation_2 hypernym "http://identifiers.org/obo.go/GO:0051437", - "http://identifiers.org/obo.go/GO:0030163" - Degradation_of_PDS1_in_PE hypernym "http://identifiers.org/obo.go/GO:0030163", - "http://identifiers.org/obo.go/GO:0051437" - Assoc_with_ESP1_to_form_PE hypernym "http://identifiers.org/obo.go/GO:0043623", - "http://identifiers.org/obo.go/GO:0005515", - "http://identifiers.org/obo.go/GO:0043027" - Disso_from_PE hypernym "http://identifiers.org/obo.go/GO:0043280", - "http://identifiers.org/obo.go/GO:0043624" - DNA_synthesis hypernym "http://identifiers.org/obo.go/GO:0006261", - "http://identifiers.org/obo.go/GO:0000082" - Negative_regulation_of_DNA_synthesis hypernym "http://identifiers.org/obo.go/GO:0008156" - Budding hypernym "http://identifiers.org/obo.go/GO:0045782" - Negative_regulation_of_Cell_budding hypernym "http://identifiers.org/obo.go/GO:0045781" - Spindle_formation hypernym "http://identifiers.org/obo.go/GO:0051225" - Spindle_disassembly hypernym "http://identifiers.org/obo.go/GO:0051228" -end - -BIOMD0000000056 is "Chen2004 - Cell Cycle Regulation" - -BIOMD0000000056 model_entity_is "http://identifiers.org/biomodels.db/MODEL6624073334" -BIOMD0000000056 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000056" -BIOMD0000000056 description "http://identifiers.org/pubmed/15169868" -BIOMD0000000056 identity "http://identifiers.org/kegg.pathway/sce04111" -BIOMD0000000056 hypernym "http://identifiers.org/obo.go/GO:0000278" -BIOMD0000000056 homolog "http://identifiers.org/reactome/REACT_152" -BIOMD0000000056 taxon "http://identifiers.org/taxonomy/4932" diff --git a/BioModelsRAG/data/BIOMD0000000057.txt b/BioModelsRAG/data/BIOMD0000000057.txt deleted file mode 100644 index 646f6989c97221e9276ec84889ec5f5d575bd46b..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000057.txt +++ /dev/null @@ -1,110 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Sneyd2002_dynamic_model_of_IP3_Receptor() - - // Compartments and Species: - compartment compartment_; - species R in compartment_, O in compartment_, I1 in compartment_, S in compartment_; - species A in compartment_, I2 in compartment_; - - // Assignment Rules: - open_probability := (0.1*O + 0.9*A)^4; - Phi1 := (k1*L1 + l2)*c/(L1 + c*(1 + L1/L3)); - Phi2 := (k2*L3 + l4*c)/(L3 + c*(1 + L3/L1)); - Phi_minus2 := (kminus2 + lminus4*c)/(1 + c/L5); - Phi3 := k3*L5/(L5 + c); - Phi4 := (k4*L5 + l6)*c/(L5 + c); - Phi_minus4 := L1*(kminus4 + lminus6)/(L1 + c); - Phi5 := (k1*L1 + l2)*c/(L1 + c); - - // Reactions: - v1: R -> O; compartment_*(Phi2*v1_IP3*R - Phi_minus2*O); - v2: R -> I1; compartment_*(Phi1*R - (v2_kminus1 + v2_lminus2)*I1); - v3: O -> S; compartment_*(Phi3*O - v3_kminus3*S); - v4: O -> A; compartment_*(Phi4*O - Phi_minus4*A); - v5: A -> I2; compartment_*(Phi5*A - (v5_kminus1 + v5_lminus2)*I2); - - // Species initializations: - R = 1; - O = 0; - I1 = 0; - S = 0; - A = 0; - I2 = 0; - - // Compartment initializations: - compartment_ = 1; - - // Variable initializations: - k1 = 0.64; - L1 = 0.12; - l2 = 1.7; - c = 10; - L3 = 0.025; - lminus2 = 0.8; - k2 = 37.4; - l4 = 1.7; - kminus2 = 1.4; - lminus4 = 2.5; - L5 = 54.7; - kminus1 = 0.04; - kminus3 = 29.8; - k3 = 0.11; - k4 = 4; - l6 = 4707; - kminus4 = 0.54; - lminus6 = 11.4; - IP3 = 10; - v1_IP3 = 10; - v2_kminus1 = 0.04; - v2_lminus2 = 0.8; - v3_kminus3 = 29.8; - v5_kminus1 = 0.04; - v5_lminus2 = 0.8; - - // Other declarations: - var open_probability, Phi1, Phi2, Phi_minus2, Phi3, Phi4, Phi_minus4, Phi5; - const compartment_, k1, L1, l2, c, L3, lminus2, k2, l4, kminus2, lminus4; - const L5, kminus1, kminus3, k3, k4, l6, kminus4, lminus6, IP3; - - // Unit definitions: - unit substance = 1e-6 mole; - - // Display Names: - substance is "micromole"; - R is "Receptor"; - O is "Open State"; - I1 is "Inactivated State 1"; - S is "Shut State"; - A is "Activated State"; - I2 is "Inactivated State 2"; - v1 is "Receptor-Open state transition"; - v2 is "Receptor-Inactivated state 1 transition"; - v3 is "Open-Shut state transition"; - v4 is "Open-Activated state transition"; - v5 is "Activated-Inactivated state 2 transition"; - - // CV terms: - compartment_ identity "http://identifiers.org/go/GO:0005829" - R hypernym "http://identifiers.org/interpro/IPR000493" - O hypernym "http://identifiers.org/interpro/IPR000493" - I1 hypernym "http://identifiers.org/interpro/IPR000493" - S hypernym "http://identifiers.org/interpro/IPR000493" - A hypernym "http://identifiers.org/interpro/IPR000493" - I2 hypernym "http://identifiers.org/interpro/IPR000493" - v1 hypernym "http://identifiers.org/go/GO:0031587", - "http://identifiers.org/go/GO:0005220" - v2 hypernym "http://identifiers.org/go/GO:0031586" - v3 hypernym "http://identifiers.org/go/GO:0031586" - v4 hypernym "http://identifiers.org/go/GO:0031587" - v5 hypernym "http://identifiers.org/go/GO:0031586" -end - -Sneyd2002_dynamic_model_of_IP3_Receptor is "Sneyd2002_IP3_Receptor" - -Sneyd2002_dynamic_model_of_IP3_Receptor model_entity_is "http://identifiers.org/biomodels.db/MODEL9098147664" -Sneyd2002_dynamic_model_of_IP3_Receptor model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000057" -Sneyd2002_dynamic_model_of_IP3_Receptor description "http://identifiers.org/pubmed/11842185" -Sneyd2002_dynamic_model_of_IP3_Receptor taxon "http://identifiers.org/taxonomy/10117" -Sneyd2002_dynamic_model_of_IP3_Receptor identity "http://identifiers.org/kegg.pathway/map04020" -Sneyd2002_dynamic_model_of_IP3_Receptor hypernym "http://identifiers.org/go/GO:0048016", - "http://identifiers.org/go/GO:0019722" diff --git a/BioModelsRAG/data/BIOMD0000000058.txt b/BioModelsRAG/data/BIOMD0000000058.txt deleted file mode 100644 index 23df4745d84a8d51e5e63a42d055990d3c2088cc..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000058.txt +++ /dev/null @@ -1,124 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Bindschadler_Ca_Oscillator() - - // Compartments and Species: - compartment compartment_; - species c1 in compartment_, h1 in compartment_, c2 in compartment_, h2 in compartment_; - - // Assignment Rules: - Phi1_c1 := r2*c1/(R1 + c1); - Phi_minus1_c1 := k1/(R3 + c1); - Phi2_c1 := (k2 + r4*c1)/(R3 + c1); - Phi3_c1 := k3/(R5 + c1); - Phi1_c2 := r2*c2/(R1 + c2); - Phi_minus1_c2 := k1/(R3 + c2); - Phi2_c2 := (k2 + r4*c2)/(R3 + c2); - Phi3_c2 := k3/(R5 + c2); - - // Reactions: - Jreceptor_Cell1: => c1; compartment_*Jreceptor_Cell1_kf*(Jreceptor_Cell1_p*h1*Phi1_c1/(Phi1_c1*Jreceptor_Cell1_p + Phi_minus1_c1))^4; - Jpump_Cell1: c1 => ; compartment_*(Jpump_Cell1_Vp*c1^2/(Jpump_Cell1_Kp^2 + c1^2)); - Jleak_Cell1: => c1; compartment_*Jleak_Cell1_Jleak; - Inactivated_to_S_Cell1: => h1; compartment_*Phi3_c1*(1 - h1); - Open_to_Inactivated_Cell1: h1 => ; compartment_*Phi1_c1*Phi2_c1*h1*Open_to_Inactivated_Cell1_p/(Phi1_c1*Open_to_Inactivated_Cell1_p + Phi_minus1_c1); - Jreceptor_Cell2: => c2; compartment_*Jreceptor_Cell2_kf*(Jreceptor_Cell2_p*h2*Phi1_c2/(Phi1_c2*Jreceptor_Cell2_p + Phi_minus1_c2))^4; - Jpump_Cell2: c2 => ; compartment_*Jpump_Cell2_Vp*c2^2/(Jpump_Cell2_Kp^2 + c2^2); - Jleak_Cell2: => c2; compartment_*Jleak_Cell2_Jleak; - Inactivated_to_S_Cell2: => h2; compartment_*Phi3_c2*(1 - h2); - Open_to_Inactivated_Cell2: h2 => ; compartment_*Phi1_c2*Phi2_c2*h2*Open_to_Inactivated_Cell2_p/(Phi1_c2*Open_to_Inactivated_Cell2_p + Phi_minus1_c2); - diffusion: c2 => c1; compartment_*diffusion_D*(c2 - c1); - - // Species initializations: - c1 = 0.3; - h1 = 0.8; - c2 = 0.1; - h2 = 0.1; - - // Compartment initializations: - compartment_ = 1; - - // Variable initializations: - r2 = 100; - R1 = 6; - k1 = 44; - R3 = 50; - k2 = 26.5; - r4 = 20; - k3 = 1.6; - R5 = 1.6; - Jreceptor_Cell1_kf = 28; - Jreceptor_Cell1_p = 0.2778; - Jpump_Cell1_Vp = 1.2; - Jpump_Cell1_Kp = 0.18; - Jleak_Cell1_Jleak = 0.2; - Open_to_Inactivated_Cell1_p = 0.2778; - Jreceptor_Cell2_kf = 28; - Jreceptor_Cell2_p = 0.2778; - Jpump_Cell2_Vp = 1.2; - Jpump_Cell2_Kp = 0.18; - Jleak_Cell2_Jleak = 0.2; - Open_to_Inactivated_Cell2_p = 0.2778; - diffusion_D = 0.01; - - // Other declarations: - var Phi1_c1, Phi_minus1_c1, Phi2_c1, Phi3_c1, Phi1_c2, Phi_minus1_c2, Phi2_c2; - var Phi3_c2; - const compartment_, r2, R1, k1, R3, k2, r4, k3, R5; - - // Unit definitions: - unit substance = 1e-6 mole; - - // Display Names: - substance is "micromole"; - c1 is "Calcium ion Cell1"; - h1 is "Receptor fraction Cell1"; - c2 is "Calcium ion Cell2"; - h2 is "Receptor fraction Cell2"; - Jreceptor_Cell1 is "IP3R mediated Ca release Cell1"; - Jpump_Cell1 is "ATPase pump mediated Ca efflux Cell1"; - Jleak_Cell1 is "IP3R independent Ca release Cell1"; - Inactivated_to_S_Cell1 is "Inactivated to Shut state transition Cell1"; - Open_to_Inactivated_Cell1 is "Open to Inactivated state transition Cell1"; - Jreceptor_Cell2 is "IP3R mediated Ca release Cell2"; - Jpump_Cell2 is "ATPase pump mediated Ca efflux Cell2"; - Jleak_Cell2 is "IP3R independent Ca release Cell2"; - Inactivated_to_S_Cell2 is "Inactivated to Shut state transition Cell2"; - Open_to_Inactivated_Cell2 is "Open to Inactivated state transition Cell2"; - diffusion is "Diffusion of Ca between cells"; - - // CV terms: - compartment_ identity "http://identifiers.org/go/GO:0005829" - c1 identity "http://identifiers.org/chebi/CHEBI:29108", - "http://identifiers.org/kegg.compound/C00076" - h1 hypernym "http://identifiers.org/interpro/IPR000493" - c2 identity "http://identifiers.org/chebi/CHEBI:29108", - "http://identifiers.org/kegg.compound/C00076" - h2 hypernym "http://identifiers.org/interpro/IPR000493" - Jreceptor_Cell1 identity "http://identifiers.org/go/GO:0005220" - Jreceptor_Cell1 hypernym "http://identifiers.org/go/GO:0007204" - Jpump_Cell1 identity "http://identifiers.org/go/GO:0005388" - Jleak_Cell1 hypernym "http://identifiers.org/go/GO:0007204" - Jleak_Cell1 hypernym "http://identifiers.org/go/GO:0051209" - Inactivated_to_S_Cell1 hypernym "http://identifiers.org/go/GO:0031586" - Open_to_Inactivated_Cell1 hypernym "http://identifiers.org/go/GO:0031586" - Jreceptor_Cell2 identity "http://identifiers.org/go/GO:0005220" - Jreceptor_Cell2 hypernym "http://identifiers.org/go/GO:0007204" - Jpump_Cell2 identity "http://identifiers.org/go/GO:0005388" - Jleak_Cell2 hypernym "http://identifiers.org/go/GO:0007204" - Jleak_Cell2 hypernym "http://identifiers.org/go/GO:0051209" - Inactivated_to_S_Cell2 hypernym "http://identifiers.org/go/GO:0031586" - Open_to_Inactivated_Cell2 hypernym "http://identifiers.org/go/GO:0031586" - diffusion hypernym "http://identifiers.org/go/GO:0015085" -end - -Bindschadler_Ca_Oscillator is "Bindschadler2001_coupled_Ca_oscillators" - -Bindschadler_Ca_Oscillator model_entity_is "http://identifiers.org/biomodels.db/MODEL9107330008" -Bindschadler_Ca_Oscillator model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000058" -Bindschadler_Ca_Oscillator description "http://identifiers.org/pubmed/12779457" -Bindschadler_Ca_Oscillator origin "http://identifiers.org/biomodels.db/MODEL9200487367" -Bindschadler_Ca_Oscillator container "http://identifiers.org/bto/BTO:0000028" -Bindschadler_Ca_Oscillator identity "http://identifiers.org/kegg.pathway/map04020" -Bindschadler_Ca_Oscillator part "http://identifiers.org/go/GO:0019722", - "http://identifiers.org/go/GO:0048016" -Bindschadler_Ca_Oscillator taxon "http://identifiers.org/taxonomy/10116" diff --git a/BioModelsRAG/data/BIOMD0000000059.txt b/BioModelsRAG/data/BIOMD0000000059.txt deleted file mode 100644 index bef3829ca86287a54a73735caa3b3a597418479e..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000059.txt +++ /dev/null @@ -1,348 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Fridlyand2003_Ca_flux_pancreatic_cells() - - // Compartments and Species: - compartment Cytoplasm, ER; - species Ca_cyt in Cytoplasm, Ca_er in ER, IP3_cyt in Cytoplasm, Na_cyt in Cytoplasm; - species ATP_cyt in Cytoplasm, $ADP_cyt in Cytoplasm; - - // Assignment Rules: - ADP_cyt := 4000 - ATP_cyt; - n_infinity := 1/(1 + exp((Vn - V)/Sn)); - tau_n := c/(exp((V - Vtau)/a) + exp((Vtau - V)/b)); - I_Vca := gmvca*pvca*(V - Vca); - I_CaPump := Pmcap*Ca_cyt^2/(Kcap^2 + Ca_cyt^2); - I_NaCa := gnaca*Ca_cyt^5*(V - Vnaca)/(Ca_cyt^5 + Knaca^5); - I_CRAN := f_CRAN*p_CRAN*(V - Vna); - I_Na := gmna*pna*(V - Vna); - I_NaK := Pnak*(F1*f_2*f_3*F4*F5*f_6 - b_1*B2*B3*B4*b_5*B6)/D; - I_KDr := gmKDr*n*(V - Vk); - I_KCa := gmkca*f_Ca*(V - Vk); - I_KATP := gmkatp*Okatp*(V - Vk); - Vca := (TV/2)*ln(Ca_ec/Ca_cyt); - Vk := TV*ln(K_ec/K_cyt); - Vna := TV*ln(Na_ec/Na_cyt); - Vnaca := TV*(3*ln(Na_ec/Na_cyt) - ln(Ca_ec/Ca_cyt)); - pvca := 1/(1 + exp((Vcah - V)/Kcah)); - f_CRAN := -gm_CRAN/(1 + exp((Ca_er - Kcar)/3)); - p_CRAN := V - V_CRAN; - pna := 1/(1 + exp((104 + V)/8)); - f_5 := f5_ast*exp(V/(2*TV)); - b_5 := b5_ast*exp(-V/(2*TV)); - F1 := f_1*Na_cyt^3; - F4 := f_4*K_ec^2; - F5 := f_5*ATP_cyt; - B2 := b_2*ADP_cyt; - B3 := b_3*Na_ec^3; - B4 := b_4*P; - B6 := b_6*Ksup^2; - D := f_2*f_3*F4*F5*f_6 + b_1*f_3*F4*F5*f_6 + b_1*B2*F4*F5*f_6 + b_1*B2*B3*F5*f_6 + b_1*B2*B3*B4*f_6 + b_1*B2*B3*B4*b_5; - f_Ca := Ca_cyt^4/(Ca_cyt^4 + Kkca^4); - Okatp := (0.08*(1 + 0.33*(ADP_cyt/Kdd)) + 0.89*(0.165*(ADP_cyt/Kdd))^2)/((1 + 0.165*(ADP_cyt/Kdd))^2*(1 + 0.135*(ADP_cyt/Ktd) + 0.05*(ATP_cyt/Ktt))); - Jerp := Pcaer*Ca_cyt^2/(Ca_cyt^2 + Kcarp^2); - O_infinity := Ca_cyt*IP3_cyt^3/((Ca_cyt + Krca)*(IP3_cyt^3 + Kip3^3)); - Jout := (Pleak + Pip3*O_infinity)*(Ca_er - Ca_cyt); - - // Rate Rules: - n' = (n_infinity - n)/tau_n; - V' = (0 - (I_Vca + I_CaPump + I_NaCa + I_CRAN + I_Na + I_NaK + I_KDr + I_KCa + I_KATP))/Cm; - - // Reactions: - Calcium_cyt_Ivca: => Ca_cyt; fi*-I_Vca/(2*F); - Calcium_cyt_Inaca: => Ca_cyt; fi*2*I_NaCa/(2*F); - Calcium_cyt_Icapump: Ca_cyt => ; fi*2*I_CaPump/(2*F); - Calcium_cyt_Jerp: 0.01 Ca_cyt => 0.03 Ca_er; Cytoplasm*Jerp; - Calcium_cyt_Jout: 0.03 Ca_er => 0.01 Ca_cyt; Jout; - Calcium_cyt_sequestration: Ca_cyt => ; Cytoplasm*ksg*Ca_cyt; - IP3_synthesis: => IP3_cyt; Cytoplasm*kip*Ca_cyt^2/(Ca_cyt^2 + Kipca^2); - IP3_degradation: IP3_cyt => ; Cytoplasm*kdip*IP3_cyt; - Na_Inaca: Na_cyt => ; 3*I_NaCa/F; - Na_Inak: Na_cyt => ; 3*I_NaK/F; - Na_Ina: => Na_cyt; -I_Na/F; - Na_Icran: => Na_cyt; -I_CRAN/F; - ATP_production: => ATP_cyt; Cytoplasm*kadp*ADP_cyt; - ATP_NaKATPase: ATP_cyt => ; I_NaK/F; - ATP_Capump: ATP_cyt => ; I_CaPump/F; - ATP_Jerp: ATP_cyt => ; Cytoplasm*Jerp/2; - ATP_Ca_dependent_consumption: ATP_cyt => ; Cytoplasm*katpca*Ca_cyt*ATP_cyt; - ATP_consumption: ATP_cyt => ; Cytoplasm*katp*ATP_cyt; - - // Species initializations: - Ca_cyt = 0.085; - Ca_er = 22.8; - IP3_cyt = 0.33; - Na_cyt = 9858; - ATP_cyt = 932.1; - - // Compartment initializations: - Cytoplasm = 7.64e-13; - ER = 2.8e-13; - - // Variable initializations: - n = 0.00123; - n_infinity has dimensionless; - tau_n has time_unit; - V = -60.9; - V has millivolt; - I_Vca has femtoampere; - I_CaPump has femtoampere; - I_NaCa has femtoampere; - I_CRAN has femtoampere; - I_Na has femtoampere; - I_NaK has femtoampere; - I_KDr has femtoampere; - I_KCa has femtoampere; - I_KATP has femtoampere; - Cm = 6158; - Cm has femtofarad; - Vca has millivolt; - TV = 26.73; - TV has millivolt; - Ca_ec = 2600; - Ca_ec has micromole_per_litre; - Vk has millivolt; - K_ec = 8000; - K_ec has micromole_per_litre; - K_cyt = 132400; - K_cyt has micromole_per_litre; - Vna has millivolt; - Na_ec = 140000; - Na_ec has micromole_per_litre; - Vnaca has millivolt; - Vcah = -19; - Vcah has millivolt; - Kcah = 9.5; - Kcah has millivolt; - gm_CRAN = 0.7; - gm_CRAN has picosiemens_per_millivolt; - Kcar = 200; - Kcar has micromole_per_litre; - p_CRAN has millivolt; - V_CRAN = 0; - V_CRAN has millivolt; - pna has dimensionless; - f5_ast = 0.002; - f5_ast has per_microM_per_millisecond; - b5_ast = 0.03; - b5_ast has per_millisecond; - f_1 = 2.5e-10; - f_1 has per_microMcube_per_millisecond; - f_4 = 1.5e-08; - f_4 has per_microMsquare_per_millisecond; - b_2 = 0.0001; - b_2 has per_microM_per_millisecond; - b_3 = 1.72e-17; - b_3 has per_microMcube_per_millisecond; - b_4 = 0.0002; - b_4 has per_microM_per_millisecond; - P = 4950; - P has micromole_per_litre; - b_6 = 6e-07; - b_6 has per_microM_per_millisecond; - Ksup = 150400; - Ksup has micromole_per_litre; - f_2 = 10; - f_2 has per_millisecond; - f_3 = 0.172; - f_3 has per_millisecond; - f_6 = 11.5; - f_6 has per_millisecond; - b_1 = 100; - b_1 has per_millisecond; - f_Ca has dimensionless; - Kkca = 0.1; - Kkca has micromole_per_litre; - Okatp has dimensionless; - Kdd = 17; - Kdd has micromole_per_litre; - Ktd = 26; - Ktd has micromole_per_litre; - Ktt = 1; - Ktt has micromole_per_litre; - Vn = -14; - Vn has millivolt; - Sn = 7; - Sn has millivolt; - c = 20; - c has time_unit; - Vtau = -75; - Vtau has millivolt; - a = 65; - a has millivolt; - b = 20; - b has millivolt; - gmvca = 770; - gmvca has picosiemens; - Pmcap = 2000; - Pmcap has femtoampere; - Kcap = 0.1; - Kcap has micromole_per_litre; - gnaca = 271; - gnaca has picosiemens; - Knaca = 0.75; - Knaca has micromole_per_litre; - gmna = 1200; - gmna has picosiemens; - Pnak = 600; - Pnak has femtoampere; - gmKDr = 3000; - gmKDr has picosiemens; - gmkca = 130; - gmkca has picosiemens; - gmkatp = 24000; - gmkatp has picosiemens; - Jerp has microM_per_millisecond; - Pcaer = 0.105; - Pcaer has microM_per_millisecond; - Kcarp = 0.5; - Kcarp has micromole_per_litre; - O_infinity has dimensionless; - Krca = 0.077; - Krca has micromole_per_litre; - Kip3 = 3.2; - Kip3 has micromole_per_litre; - Jout has micromole_per_millisecond; - Pleak = 1e-16; - Pleak has litres_per_millisecond; - Pip3 = 1.2e-15; - Pip3 has litres_per_millisecond; - fi = 0.01; - fi has dimensionless; - F = 9.6485e+16; - F has fA_msec_per_micromole; - ksg = 0.0001; - ksg has per_millisecond; - fer = 0.03; - fer has dimensionless; - kip = 0.0003; - kip has microM_per_millisecond; - Kipca = 0.4; - Kipca has micromole_per_litre; - kdip = 4e-05; - kdip has per_millisecond; - kadp = 0.00037; - kadp has per_millisecond; - katpca = 5e-05; - katpca has per_microM_per_millisecond; - katp = 5e-05; - katp has per_millisecond; - - // Other declarations: - var n, n_infinity, tau_n, V, I_Vca, I_CaPump, I_NaCa, I_CRAN, I_Na, I_NaK; - var I_KDr, I_KCa, I_KATP, Vca, Vk, Vna, Vnaca, pvca, f_CRAN, p_CRAN, pna; - var f_5, b_5, F1, F4, F5, B2, B3, B4, B6, D, f_Ca, Okatp, Jerp, Pcaer, O_infinity; - var Jout; - const Cytoplasm, ER, Cm, TV, Ca_ec, K_ec, K_cyt, Na_ec, Vcah, Kcah, gm_CRAN; - const Kcar, V_CRAN, f5_ast, b5_ast, f_1, f_4, b_2, b_3, b_4, P, b_6, Ksup; - const f_2, f_3, f_6, b_1, Kkca, Kdd, Ktd, Ktt, Vn, Sn, c, Vtau, a, b, gmvca; - const Pmcap, Kcap, gnaca, Knaca, gmna, Pnak, gmKDr, gmkca, gmkatp, Kcarp; - const Krca, Kip3, Pleak, Pip3, fi, F, ksg, fer, kip, Kipca, kdip, kadp; - const katpca, katp; - - // Unit definitions: - unit substance = 1e-6 mole; - unit time_unit = 1e-3 second; - unit millivolt = 1e-3 volt; - unit femtoampere = 1e-15 ampere; - unit micromole_per_litre = 1e-6 mole / litre; - unit picosiemens = 1e-12 siemens; - unit femtofarad = 1e-15 farad; - unit per_millisecond = 1 / 1e-3 second; - unit picosiemens_per_millivolt = 1e-12 siemens / 1e-3 volt; - unit micromole_per_millisecond = 1e-6 mole / 1e-3 second; - unit microM_per_millisecond = 1e-6 mole / (1e-3 second * litre); - unit litres_per_millisecond = litre / 1e-3 second; - unit per_microM_per_millisecond = litre / (1e-6 mole * 1e-3 second); - unit per_microMcube_per_millisecond = litre^3 / ((1e-6 mole)^3 * 1e-3 second); - unit per_microMsquare_per_millisecond = litre^2 / ((1e-6 mole)^2 * 1e-3 second); - unit per_microM = litre / 1e-6 mole; - unit fA_msec_per_micromole = 1e-15 ampere * 1e-3 second / 1e-6 mole; - - // Display Names: - substance is "Micromole"; - time_unit is "milliseconds"; - millivolt is "Voltage"; - femtoampere is "Current"; - micromole_per_litre is "Concentration"; - picosiemens is "Conductance"; - femtofarad is "Capacitance"; - per_millisecond is "Time inverse"; - picosiemens_per_millivolt is "Conductance coefficient"; - micromole_per_millisecond is "amount per time"; - microM_per_millisecond is "concentration per time"; - litres_per_millisecond is "volume per time"; - per_microM_per_millisecond is "per concentration per time"; - per_microMcube_per_millisecond is "per concentration cubed per time"; - per_microMsquare_per_millisecond is "per Concentration square per time"; - per_microM is "per concentration"; - fA_msec_per_micromole is "Faraday constant"; - Cytoplasm is "cytoplasm"; - ER is "endoplasmic reticulum"; - Ca_cyt is "Cytosolic Calcium"; - Ca_er is "ER Calcium"; - IP3_cyt is "Cytosolic IP3"; - Na_cyt is "Cytosolic Sodium"; - ATP_cyt is "Cytosolic ATP"; - ADP_cyt is "Cytosolic ADP"; - F is "Faraday's constant"; - kip is "IP3 production rate constant"; - Kipca is "half activation cytosolic Ca"; - kdip is "IP3 degradation rate constant"; - kadp is "ATP production rate constant"; - katpca is "Ca dependent ATP consumption"; - katp is "Rate constant of ATP consumption"; - - // CV terms: - Cytoplasm identity "http://identifiers.org/go/GO:0005737" - ER identity "http://identifiers.org/go/GO:0005783" - Ca_cyt identity "http://identifiers.org/chebi/CHEBI:29108", - "http://identifiers.org/kegg.compound/C00076" - Ca_er identity "http://identifiers.org/chebi/CHEBI:29108", - "http://identifiers.org/kegg.compound/C00076" - IP3_cyt identity "http://identifiers.org/chebi/CHEBI:16595", - "http://identifiers.org/kegg.compound/C01245" - Na_cyt identity "http://identifiers.org/chebi/CHEBI:29101", - "http://identifiers.org/kegg.compound/C01330" - ATP_cyt identity "http://identifiers.org/chebi/CHEBI:15422", - "http://identifiers.org/kegg.compound/C00002" - ADP_cyt identity "http://identifiers.org/chebi/CHEBI:16761", - "http://identifiers.org/kegg.compound/C00008" - Calcium_cyt_Ivca hypernym "http://identifiers.org/go/GO:0005245" - Calcium_cyt_Inaca hypernym "http://identifiers.org/go/GO:0005432" - Calcium_cyt_Icapump identity "http://identifiers.org/ec-code/3.6.3.8" - Calcium_cyt_Icapump part "http://identifiers.org/go/GO:0005388", - "http://identifiers.org/go/GO:0005524" - Calcium_cyt_Jerp identity "http://identifiers.org/ec-code/3.6.3.8" - Calcium_cyt_Jerp part "http://identifiers.org/go/GO:0005388", - "http://identifiers.org/go/GO:0005524" - Calcium_cyt_Jout part "http://identifiers.org/go/GO:0007204", - "http://identifiers.org/go/GO:0005220" - Calcium_cyt_sequestration identity "http://identifiers.org/go/GO:0051208" - IP3_synthesis identity "http://identifiers.org/ec-code/3.1.4.11", - "http://identifiers.org/go/GO:0004435" - Na_Inaca identity "http://identifiers.org/go/GO:0005432" - Na_Inak identity "http://identifiers.org/ec-code/3.6.3.9", - "http://identifiers.org/go/GO:0005391" - Na_Ina hypernym "http://identifiers.org/go/GO:0005248" - Na_Icran hypernym "http://identifiers.org/go/GO:0005227" - ATP_production identity "http://identifiers.org/go/GO:0006754" - ATP_NaKATPase identity "http://identifiers.org/ec-code/3.6.3.9", - "http://identifiers.org/go/GO:0005391" - ATP_Capump identity "http://identifiers.org/ec-code/3.6.3.8", - "http://identifiers.org/go/GO:0005388" - ATP_Jerp identity "http://identifiers.org/ec-code/3.6.3.8", - "http://identifiers.org/go/GO:0005388" - ATP_Ca_dependent_consumption identity "http://identifiers.org/go/GO:0030899" - ATP_consumption identity "http://identifiers.org/go/GO:0006200" -end - -Fridlyand2003_Ca_flux_pancreatic_cells is "Fridlyand2003_Calcium_flux" - -Fridlyand2003_Ca_flux_pancreatic_cells model_entity_is "http://identifiers.org/biomodels.db/MODEL0928773489" -Fridlyand2003_Ca_flux_pancreatic_cells model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000059" -Fridlyand2003_Ca_flux_pancreatic_cells description "http://identifiers.org/pubmed/12644446" -Fridlyand2003_Ca_flux_pancreatic_cells taxon "http://identifiers.org/taxonomy/10090" -Fridlyand2003_Ca_flux_pancreatic_cells identity "http://identifiers.org/kegg.pathway/map04020" -Fridlyand2003_Ca_flux_pancreatic_cells part "http://identifiers.org/go/GO:0050848", - "http://identifiers.org/go/GO:0050796" -Fridlyand2003_Ca_flux_pancreatic_cells container "http://identifiers.org/bto/BTO:0000783" diff --git a/BioModelsRAG/data/BIOMD0000000060.txt b/BioModelsRAG/data/BIOMD0000000060.txt deleted file mode 100644 index bab99ae6c925c256bc68c8c9deb0a58d35908083..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000060.txt +++ /dev/null @@ -1,87 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Keizer1996_Ryanodine_receptor_adaptation() - - // Compartments and Species: - compartment compartment_; - substanceOnly species Pc1 in compartment_, Po2 in compartment_, Po1 in compartment_; - substanceOnly species Pc2 in compartment_; - - // Assignment Rules: - Open_probability := Po1 + Po2; - - // Reactions: - Closed_state_1: Po1 -> Pc1; Closed_state_1_ka_minus*Po1 - Closed_state_1_ka_plus*Closed_state_1_Ca^Closed_state_1_n*Pc1; - Open_state_2: Po1 -> Po2; Open_state_2_kb_plus*Open_state_2_Ca^Open_state_2_m*Po1 - Open_state_2_kb_minus*Po2; - Closed_State_2: Po1 -> Pc2; Closed_State_2_kc_plus*Po1 - Closed_State_2_kc_minus*Pc2; - - // Species initializations: - Pc1 = 0.963/compartment_; - Po2 = 0; - Po1 = 0; - Pc2 = 0.037/compartment_; - - // Compartment initializations: - compartment_ = 1; - Open_probability has dimensionless; - - // Variable initializations: - Closed_state_1_ka_minus = 28.8; - Closed_state_1_ka_minus has per_second; - Closed_state_1_ka_plus = 1500; - Closed_state_1_ka_plus has per_microM4sec; - Closed_state_1_Ca = 0.9; - Closed_state_1_Ca has microM; - Closed_state_1_n = 4; - Closed_state_1_n has dimensionless; - Open_state_2_kb_plus = 1500; - Open_state_2_kb_plus has per_microM3sec; - Open_state_2_Ca = 0.9; - Open_state_2_Ca has microM; - Open_state_2_m = 3; - Open_state_2_m has dimensionless; - Open_state_2_kb_minus = 385.9; - Open_state_2_kb_minus has per_second; - Closed_State_2_kc_plus = 1.75; - Closed_State_2_kc_plus has per_second; - Closed_State_2_kc_minus = 0.1; - Closed_State_2_kc_minus has per_second; - - // Other declarations: - var Open_probability; - const compartment_; - - // Unit definitions: - unit per_microM4sec = litre^4 / ((1e-6 mole)^4 * second); - unit per_microM3sec = litre^3 / ((1e-6 mole)^3 * second); - unit per_second = 1 / second; - unit microM = 1e-6 mole / litre; - unit substance = dimensionless; - - // Display Names: - per_microM4sec is "microM-4sec-1"; - per_microM3sec is "microM-3sec-1"; - substance is "normalized substance"; - Closed_State_2 is "Closed State 2"; - - // CV terms: - compartment_ identity "http://identifiers.org/go/GO:0005623" - Pc1 hypernym "http://identifiers.org/uniprot/P21817" - Po2 hypernym "http://identifiers.org/uniprot/P21817" - Po1 hypernym "http://identifiers.org/uniprot/P21817" - Pc2 hypernym "http://identifiers.org/uniprot/P21817" - Closed_state_1 hypernym "http://identifiers.org/go/GO:0005219" - Open_state_2 hypernym "http://identifiers.org/go/GO:0005219" - Closed_State_2 hypernym "http://identifiers.org/go/GO:0005219" -end - -Keizer1996_Ryanodine_receptor_adaptation is "Keizer1996_Ryanodine_receptor_adaptation" - -Keizer1996_Ryanodine_receptor_adaptation model_entity_is "http://identifiers.org/biomodels.db/MODEL0332756009" -Keizer1996_Ryanodine_receptor_adaptation model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000060" -Keizer1996_Ryanodine_receptor_adaptation description "http://identifiers.org/pubmed/8968617" -Keizer1996_Ryanodine_receptor_adaptation taxon "http://identifiers.org/taxonomy/131567" -Keizer1996_Ryanodine_receptor_adaptation identity "http://identifiers.org/kegg.pathway/map04020" -Keizer1996_Ryanodine_receptor_adaptation part "http://identifiers.org/go/GO:0005219", - "http://identifiers.org/go/GO:0048763", - "http://identifiers.org/go/GO:0019722" -Keizer1996_Ryanodine_receptor_adaptation property "http://identifiers.org/mamo/MAMO_0000046" diff --git a/BioModelsRAG/data/BIOMD0000000061.txt b/BioModelsRAG/data/BIOMD0000000061.txt deleted file mode 100644 index 8841eb4a4aeff0b8a0785fdeb3ec7814f970b348..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000061.txt +++ /dev/null @@ -1,384 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Hynne2001_Glycolysis() - - // Compartments and Species: - compartment extracellular, cytosol; - species GlcX in extracellular, Glc in cytosol, ATP in cytosol, G6P in cytosol; - species ADP in cytosol, F6P in cytosol, FBP in cytosol, GAP in cytosol; - species DHAP in cytosol, NAD in cytosol, BPG in cytosol, NADH in cytosol; - species PEP in cytosol, Pyr in cytosol, ACA in cytosol, EtOH in cytosol; - species EtOHX in extracellular, Glyc in cytosol, GlycX in extracellular; - species ACAX in extracellular, CNX in extracellular, AMP in cytosol, $P in extracellular; - species $CNX0 in extracellular, $GlcX0 in extracellular; - - // Reactions: - vinGlc: $GlcX0 -> GlcX; extracellular*vinGlc_k0*(GlcX0 - GlcX); - vGlcTrans: GlcX -> 59 Glc; (extracellular*vGlcTrans_V2f/vGlcTrans_Yvol)*(GlcX/vGlcTrans_K2Glc/(1 + GlcX/vGlcTrans_K2Glc + ((vGlcTrans_P2*(GlcX/vGlcTrans_K2Glc) + 1)/(vGlcTrans_P2*(Glc/vGlcTrans_K2Glc) + 1))*(1 + Glc/vGlcTrans_K2Glc + G6P/vGlcTrans_K2IG6P + Glc*G6P/(vGlcTrans_K2Glc*vGlcTrans_K2IIG6P)))) - (cytosol*vGlcTrans_V2r/vGlcTrans_Yvol)*(Glc/vGlcTrans_K2Glc/(1 + Glc/vGlcTrans_K2Glc + ((vGlcTrans_P2*(Glc/vGlcTrans_K2Glc) + 1)/(vGlcTrans_P2*(GlcX/vGlcTrans_K2Glc) + 1))*(1 + GlcX/vGlcTrans_K2Glc) + G6P/vGlcTrans_K2IG6P + Glc*G6P/(vGlcTrans_K2Glc*vGlcTrans_K2IIG6P))); - vHK: ATP + Glc -> G6P + ADP; cytosol*vHK_V3m*ATP*Glc/(vHK_K3DGlc*vHK_K3ATP + vHK_K3Glc*ATP + vHK_K3ATP*Glc + Glc*ATP); - vPGI: G6P -> F6P; cytosol*(vPGI_V4f*G6P/(vPGI_K4G6P + G6P + (vPGI_K4G6P/vPGI_K4F6P)*F6P) - vPGI_V4r*(F6P/vPGI_K4eq)/(vPGI_K4G6P + G6P + (vPGI_K4G6P/vPGI_K4F6P)*F6P)); - vPFK: F6P + ATP -> FBP + ADP; cytosol*(vPFK_V5m*F6P^2/(vPFK_K5*(1 + vPFK_kappa5*(ATP/AMP)*(ATP/AMP)) + F6P^2)); - vALD: FBP -> GAP + DHAP; cytosol*(vALD_V6f*FBP/(vALD_K6FBP + FBP + GAP*vALD_K6DHAP*vALD_V6f/(vALD_K6eq*vALD_V6f*vALD_ratio6) + DHAP*vALD_K6GAP*vALD_V6f/(vALD_K6eq*vALD_V6f*vALD_ratio6) + FBP*GAP/vALD_K6IGAP + GAP*DHAP*vALD_V6f/(vALD_K6eq*vALD_V6f*vALD_ratio6)) - vALD_V6f*GAP*DHAP/vALD_K6eq/(vALD_K6FBP + FBP + GAP*vALD_K6DHAP*vALD_V6f/(vALD_K6eq*vALD_V6f*vALD_ratio6) + DHAP*vALD_K6GAP*vALD_V6f/(vALD_K6eq*vALD_V6f*vALD_ratio6) + FBP*GAP/vALD_K6IGAP + GAP*DHAP*vALD_V6f/(vALD_K6eq*vALD_V6f*vALD_ratio6))); - vTIM: DHAP -> GAP; cytosol*(vTIM_V7f*DHAP/(vTIM_K7DHAP + DHAP + (vTIM_K7DHAP/vTIM_K7GAP)*GAP) - vTIM_V7r*(GAP/vTIM_K7eq)/(vTIM_K7DHAP + DHAP + (vTIM_K7DHAP/vTIM_K7GAP)*GAP)); - vGAPDH: GAP + NAD -> NADH + BPG; cytosol*(vGAPDH_V8f*GAP*NAD/vGAPDH_K8GAP/vGAPDH_K8NAD/((1 + GAP/vGAPDH_K8GAP + BPG/vGAPDH_K8BPG)*(1 + NAD/vGAPDH_K8NAD + NADH/vGAPDH_K8NADH)) - vGAPDH_V8r*BPG*NADH/vGAPDH_K8eq/vGAPDH_K8GAP/vGAPDH_K8NAD/((1 + GAP/vGAPDH_K8GAP + BPG/vGAPDH_K8BPG)*(1 + NAD/vGAPDH_K8NAD + NADH/vGAPDH_K8NADH))); - vlpPEP: BPG + ADP -> PEP + ATP; cytosol*(vlpPEP_k9f*BPG*ADP - vlpPEP_k9r*PEP*ATP); - vPK: ADP + PEP -> Pyr + ATP; cytosol*(vPK_V10m*ADP*PEP/((vPK_K10PEP + PEP)*(vPK_K10ADP + ADP))); - vPDC: Pyr -> ACA; cytosol*(vPDC_V11m*Pyr/(vPDC_K11 + Pyr)); - vADH: NADH + ACA -> NAD + EtOH; cytosol*(vADH_V12m*ACA*NADH/((vADH_K12NADH + NADH)*(vADH_K12ACA + ACA))); - vdifEtOH: 59 EtOH -> EtOHX; (vdifEtOH_k13/vdifEtOH_Yvol)*(cytosol*EtOH - extracellular*EtOHX); - voutEtOH: EtOHX -> $P; extracellular*voutEtOH_k0*EtOHX; - vlpGlyc: DHAP + NADH -> Glyc + NAD; cytosol*(vlpGlyc_V15m*DHAP/(vlpGlyc_K15DHAP*(1 + (vlpGlyc_K15INADH/NADH)*(1 + NAD/vlpGlyc_K15INAD)) + DHAP*(1 + (vlpGlyc_K15NADH/NADH)*(1 + NAD/vlpGlyc_K15INAD)))); - vdifGlyc: 59 Glyc -> GlycX; (vdifGlyc_k16/vdifGlyc_Yvol)*(cytosol*Glyc - extracellular*GlycX); - voutGlyc: GlycX -> $P; extracellular*voutGlyc_k0*GlycX; - vdifACA: 59 ACA -> ACAX; (vdifACA_k18/vdifACA_Yvol)*(cytosol*ACA - extracellular*ACAX); - voutACA: ACAX -> $P; extracellular*voutACA_k0*ACAX; - vlacto: CNX + ACAX -> $P; extracellular*vlacto_k20*ACAX*CNX; - vinCN: $CNX0 -> CNX; extracellular*vinCN_k0*(CNX0 - CNX); - vstorage: ATP + G6P -> ADP; cytosol*vstorage_k22*ATP*G6P; - vconsum: ATP -> ADP; cytosol*vconsum_k23*ATP; - vAK: ATP + AMP -> 2 ADP; cytosol*(vAK_k24f*AMP*ATP - vAK_k24r*ADP^2); - - // Species initializations: - GlcX = 6.7; - Glc = 0.573074; - ATP = 2.1; - G6P = 4.2; - ADP = 1.5; - F6P = 0.49; - FBP = 4.64; - GAP = 0.115; - DHAP = 2.95; - NAD = 0.65; - BPG = 0.00027; - NADH = 0.33; - PEP = 0.04; - Pyr = 8.7; - ACA = 1.48153; - EtOH = 19.2379; - EtOHX = 16.4514; - Glyc = 4.196; - GlycX = 1.68478; - ACAX = 1.28836; - CNX = 5.20358; - AMP = 0.33; - P = 0; - CNX0 = 5.6; - GlcX0 = 24; - - // Compartment initializations: - extracellular = 1; - cytosol = 1; - - // Variable initializations: - vinGlc_k0 = 0.048; - vinGlc_k0 has min_inverse; - vGlcTrans_V2f = 1014.96; - vGlcTrans_V2f has mM_per_minute; - vGlcTrans_Yvol = 59; - vGlcTrans_Yvol has dimensionless; - vGlcTrans_K2Glc = 1.7; - vGlcTrans_K2Glc has mM; - vGlcTrans_P2 = 1; - vGlcTrans_P2 has dimensionless; - vGlcTrans_K2IG6P = 1.2; - vGlcTrans_K2IG6P has mM; - vGlcTrans_K2IIG6P = 7.2; - vGlcTrans_K2IIG6P has mM; - vGlcTrans_V2r = 1014.96; - vGlcTrans_V2r has mM_per_minute; - vHK_V3m = 51.7547; - vHK_V3m has mM_per_minute; - vHK_K3DGlc = 0.37; - vHK_K3DGlc has mM; - vHK_K3ATP = 0.1; - vHK_K3ATP has mM; - vHK_K3Glc = 0; - vHK_K3Glc has mM; - vPGI_V4f = 496.042; - vPGI_V4f has mM_per_minute; - vPGI_K4G6P = 0.8; - vPGI_K4G6P has mM; - vPGI_K4F6P = 0.15; - vPGI_K4F6P has mM; - vPGI_V4r = 496.042; - vPGI_V4r has mM_per_minute; - vPGI_K4eq = 0.13; - vPGI_K4eq has dimensionless; - vPFK_V5m = 45.4327; - vPFK_V5m has mM_per_minute; - vPFK_K5 = 0.021; - vPFK_K5 has mM_squared; - vPFK_kappa5 = 0.15; - vPFK_kappa5 has dimensionless; - vALD_V6f = 2207.82; - vALD_V6f has mM_per_minute; - vALD_K6FBP = 0.3; - vALD_K6FBP has mM; - vALD_K6DHAP = 2; - vALD_K6DHAP has mM; - vALD_K6eq = 0.081; - vALD_K6eq has mM; - vALD_ratio6 = 5; - vALD_ratio6 has dimensionless; - vALD_K6GAP = 4; - vALD_K6GAP has mM; - vALD_K6IGAP = 10; - vALD_K6IGAP has mM; - vTIM_V7f = 116.365; - vTIM_V7f has mM_per_minute; - vTIM_K7DHAP = 1.23; - vTIM_K7DHAP has mM; - vTIM_K7GAP = 1.27; - vTIM_K7GAP has mM; - vTIM_V7r = 116.365; - vTIM_V7r has mM_per_minute; - vTIM_K7eq = 0.055; - vTIM_K7eq has dimensionless; - vGAPDH_V8f = 833.858; - vGAPDH_V8f has mM_per_minute; - vGAPDH_K8GAP = 0.6; - vGAPDH_K8GAP has mM; - vGAPDH_K8NAD = 0.1; - vGAPDH_K8NAD has mM; - vGAPDH_K8BPG = 0.01; - vGAPDH_K8BPG has mM; - vGAPDH_K8NADH = 0.06; - vGAPDH_K8NADH has mM; - vGAPDH_V8r = 833.858; - vGAPDH_V8r has mM_per_minute; - vGAPDH_K8eq = 0.0055; - vGAPDH_K8eq has dimensionless; - vlpPEP_k9f = 443866; - vlpPEP_k9f has mM_inverse_min_inverse; - vlpPEP_k9r = 1528.62; - vlpPEP_k9r has mM_inverse_min_inverse; - vPK_V10m = 343.096; - vPK_V10m has mM_per_minute; - vPK_K10PEP = 0.2; - vPK_K10PEP has mM; - vPK_K10ADP = 0.17; - vPK_K10ADP has mM; - vPDC_V11m = 53.1328; - vPDC_V11m has mM_per_minute; - vPDC_K11 = 0.3; - vPDC_K11 has mM; - vADH_V12m = 89.8023; - vADH_V12m has mM_per_minute; - vADH_K12NADH = 0.1; - vADH_K12NADH has mM; - vADH_K12ACA = 0.71; - vADH_K12ACA has mM; - vdifEtOH_k13 = 16.72; - vdifEtOH_k13 has min_inverse; - vdifEtOH_Yvol = 59; - vdifEtOH_Yvol has dimensionless; - voutEtOH_k0 = 0.048; - voutEtOH_k0 has min_inverse; - vlpGlyc_V15m = 81.4797; - vlpGlyc_V15m has mM_per_minute; - vlpGlyc_K15DHAP = 25; - vlpGlyc_K15DHAP has mM; - vlpGlyc_K15INADH = 0.034; - vlpGlyc_K15INADH has mM; - vlpGlyc_K15INAD = 0.13; - vlpGlyc_K15INAD has mM; - vlpGlyc_K15NADH = 0.13; - vlpGlyc_K15NADH has mM; - vdifGlyc_k16 = 1.9; - vdifGlyc_k16 has min_inverse; - vdifGlyc_Yvol = 59; - vdifGlyc_Yvol has dimensionless; - voutGlyc_k0 = 0.048; - voutGlyc_k0 has min_inverse; - vdifACA_k18 = 24.7; - vdifACA_k18 has min_inverse; - vdifACA_Yvol = 59; - vdifACA_Yvol has dimensionless; - voutACA_k0 = 0.048; - voutACA_k0 has min_inverse; - vlacto_k20 = 0.00283828; - vlacto_k20 has mM_inverse_min_inverse; - vinCN_k0 = 0.048; - vinCN_k0 has min_inverse; - vstorage_k22 = 2.25932; - vstorage_k22 has mM_inverse_min_inverse; - vconsum_k23 = 3.2076; - vconsum_k23 has min_inverse; - vAK_k24f = 432.9; - vAK_k24f has mM_inverse_min_inverse; - vAK_k24r = 133.333; - vAK_k24r has mM_inverse_min_inverse; - - // Other declarations: - const extracellular, cytosol; - - // Unit definitions: - unit substance = 1e-3 mole; - unit time_unit = 60 second; - unit mM_per_minute = 1e-3 mole / (litre * 60 second); - unit min_inverse = 1 / 60 second; - unit mM_inverse_min_inverse = litre / (1e-3 mole * 60 second); - unit mM_squared = (1e-3 mole)^2 / litre^2; - unit mM = 1e-3 mole / litre; - - // Display Names: - substance is "millimole"; - time_unit is "minute"; - mM_per_minute is "mM per minute"; - min_inverse is "minute inverse"; - mM_inverse_min_inverse is "mM inverse min inverse"; - mM_squared is "mM squared"; - mM is "milliMolar"; - GlcX is "Extracellular glucose"; - Glc is "Cytosolic glucose"; - G6P is "Glucose-6-Phosphate"; - F6P is "Fructose-6-Phosphate"; - FBP is "Fructose 1,6-bisphosphate"; - GAP is "Glyceraldehyde 3-phosphate"; - DHAP is "Dihydroxyacetone phosphate"; - BPG is "1,3-Bisphosphoglycerate"; - PEP is "Phosphoenolpyruvate"; - Pyr is "Pyruvate"; - ACA is "Acetaldehyde"; - EtOHX is "Extracellular ethanol"; - Glyc is "Glycerol"; - GlycX is "Extracellular glycerol"; - ACAX is "Extracellular acetaldehyde"; - CNX is "Extracellular cyanide"; - CNX0 is "Mixed flow cyanide"; - GlcX0 is "Mixed flow glucose"; - vinGlc is "Glucose Mixed flow to extracellular medium"; - vGlcTrans is "Glucose uptake"; - vHK is "Hexokinase"; - vPGI is "Phosphoglucoisomerase"; - vPFK is "Phosphofructokinase"; - vALD is "Aldolase"; - vTIM is "Triosephosphate isomerase"; - vGAPDH is "Glyceraldehyde 3-phosphate dehydrogenase"; - vlpPEP is "Phosphoenolpyruvate synthesis"; - vPK is "Pyruvate kinase"; - vPDC is "Pyruvate decarboxylase"; - vADH is "Alcohol dehydrogenase"; - vdifEtOH is "Ethanol out"; - voutEtOH is "Ethanol flow"; - vlpGlyc is "Glycerol synthesis"; - vdifGlyc is "Glycerol out"; - voutGlyc is "Glycerol flow"; - vdifACA is "Acetaldehyde out"; - voutACA is "Acetaldehyde flow"; - vlacto is "Cyanide-Acetaldehyde flow"; - vinCN is "Cyanide flow"; - vstorage is "Storage"; - vconsum is "ATP consumption"; - vAK is "Adenylate kinase"; - - // CV terms: - extracellular hypernym "http://identifiers.org/obo.go/GO:0005576" - cytosol hypernym "http://identifiers.org/obo.go/GO:0005829" - GlcX identity "http://identifiers.org/chebi/CHEBI:17234", - "http://identifiers.org/kegg.compound/C00293" - Glc identity "http://identifiers.org/chebi/CHEBI:17234", - "http://identifiers.org/kegg.compound/C00293" - ATP identity "http://identifiers.org/chebi/CHEBI:15422", - "http://identifiers.org/kegg.compound/C00002" - G6P identity "http://identifiers.org/chebi/CHEBI:15954", - "http://identifiers.org/kegg.compound/C00092" - ADP identity "http://identifiers.org/chebi/CHEBI:16761", - "http://identifiers.org/kegg.compound/C00008" - F6P identity "http://identifiers.org/chebi/CHEBI:20935", - "http://identifiers.org/kegg.compound/C00085" - FBP identity "http://identifiers.org/chebi/CHEBI:16905", - "http://identifiers.org/kegg.compound/C00354" - GAP identity "http://identifiers.org/chebi/CHEBI:29052", - "http://identifiers.org/kegg.compound/C00118" - DHAP identity "http://identifiers.org/chebi/CHEBI:16108", - "http://identifiers.org/kegg.compound/C00111" - NAD identity "http://identifiers.org/chebi/CHEBI:15846", - "http://identifiers.org/kegg.compound/C00003" - BPG identity "http://identifiers.org/chebi/CHEBI:16001", - "http://identifiers.org/kegg.compound/C00236" - NADH identity "http://identifiers.org/chebi/CHEBI:16908", - "http://identifiers.org/kegg.compound/C00004" - PEP identity "http://identifiers.org/kegg.compound/C00074", - "http://identifiers.org/chebi/CHEBI:18021" - PEP identity "http://identifiers.org/chebi/CHEBI:18021" - Pyr identity "http://identifiers.org/chebi/CHEBI:15361" - Pyr identity "http://identifiers.org/kegg.compound/C00022", - "http://identifiers.org/chebi/CHEBI:32816" - ACA identity "http://identifiers.org/chebi/CHEBI:15343", - "http://identifiers.org/kegg.compound/C00084" - EtOH identity "http://identifiers.org/chebi/CHEBI:16236", - "http://identifiers.org/kegg.compound/C00469" - EtOHX identity "http://identifiers.org/chebi/CHEBI:16236", - "http://identifiers.org/kegg.compound/C000469" - Glyc identity "http://identifiers.org/chebi/CHEBI:17754", - "http://identifiers.org/kegg.compound/C00116" - GlycX identity "http://identifiers.org/chebi/CHEBI:17754", - "http://identifiers.org/kegg.compound/C00116" - ACAX identity "http://identifiers.org/chebi/CHEBI:15343", - "http://identifiers.org/kegg.compound/C00084" - CNX identity "http://identifiers.org/chebi/CHEBI:17514", - "http://identifiers.org/kegg.compound/C00177" - AMP identity "http://identifiers.org/chebi/CHEBI:16027", - "http://identifiers.org/kegg.compound/C00020" - CNX0 identity "http://identifiers.org/chebi/CHEBI:17514", - "http://identifiers.org/kegg.compound/C00177" - GlcX0 identity "http://identifiers.org/chebi/CHEBI:17234", - "http://identifiers.org/kegg.compound/C00293" - vinGlc hypernym "http://identifiers.org/obo.go/GO:0015758" - vGlcTrans homolog "http://identifiers.org/reactome/REACT_212" - vGlcTrans hypernym "http://identifiers.org/obo.go/GO:0046323" - vHK homolog "http://identifiers.org/reactome/REACT_1318" - vHK identity "http://identifiers.org/ec-code/2.7.1.2", - "http://identifiers.org/kegg.reaction/R00299" - vPGI identity "http://identifiers.org/ec-code/5.3.1.9", - "http://identifiers.org/kegg.reaction/R00771" - vPGI homolog "http://identifiers.org/reactome/REACT_1164" - vPFK identity "http://identifiers.org/ec-code/2.7.1.11", - "http://identifiers.org/kegg.reaction/R00756" - vPFK homolog "http://identifiers.org/reactome/REACT_1840" - vALD identity "http://identifiers.org/ec-code/4.1.2.13", - "http://identifiers.org/kegg.reaction/R01070" - vTIM homolog "http://identifiers.org/reactome/REACT_1693" - vTIM identity "http://identifiers.org/ec-code/5.3.1.1", - "http://identifiers.org/kegg.reaction/R01015" - vGAPDH homolog "http://identifiers.org/reactome/REACT_587" - vGAPDH identity "http://identifiers.org/ec-code/1.2.1.12", - "http://identifiers.org/kegg.reaction/R01061" - vlpPEP homolog "http://identifiers.org/reactome/REACT_1771" - vlpPEP part "http://identifiers.org/kegg.reaction/R01512", - "http://identifiers.org/kegg.reaction/R01518", - "http://identifiers.org/kegg.reaction/R00658" - vlpPEP part "http://identifiers.org/ec-code/2.7.2.3", - "http://identifiers.org/ec-code/5.4.2.1", - "http://identifiers.org/ec-code/4.2.1.11" - vPK homolog "http://identifiers.org/reactome/REACT_1911" - vPK identity "http://identifiers.org/ec-code/2.7.1.40", - "http://identifiers.org/kegg.reaction/R00200" - vPDC identity "http://identifiers.org/ec-code/4.1.1.1", - "http://identifiers.org/kegg.reaction/R00224" - vADH identity "http://identifiers.org/ec-code/1.1.1.1", - "http://identifiers.org/kegg.reaction/R00754" - vADH homolog "http://identifiers.org/reactome/REACT_799" - vdifEtOH hypernym "http://identifiers.org/obo.go/GO:0015850" - voutEtOH hypernym "http://identifiers.org/obo.go/GO:0015850" - vlpGlyc part "http://identifiers.org/kegg.reaction/R01034", - "http://identifiers.org/kegg.reaction/R01011" - vlpGlyc part "http://identifiers.org/ec-code/1.1.1.6", - "http://identifiers.org/ec-code/2.7.1.29" - vdifGlyc hypernym "http://identifiers.org/obo.go/GO:0015850" - voutGlyc hypernym "http://identifiers.org/obo.go/GO:0015850" - vstorage hypernym "http://identifiers.org/obo.go/GO:0043211" - vconsum hypernym "http://identifiers.org/obo.go/GO:0006200" - vAK hypernym "http://identifiers.org/ec-code/2.7.4.3", - "http://identifiers.org/obo.go/GO:0004017" -end - -Hynne2001_Glycolysis is "Hynne2001_Glycolysis" - -Hynne2001_Glycolysis model_entity_is "http://identifiers.org/biomodels.db/MODEL6624167348" -Hynne2001_Glycolysis model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000061" -Hynne2001_Glycolysis description "http://identifiers.org/pubmed/11744196" -Hynne2001_Glycolysis taxon "http://identifiers.org/taxonomy/4932" -Hynne2001_Glycolysis homolog "http://identifiers.org/reactome/REACT_1383" -Hynne2001_Glycolysis hypernym "http://identifiers.org/obo.go/GO:0006096" -Hynne2001_Glycolysis identity "http://identifiers.org/kegg.pathway/sce00010" diff --git a/BioModelsRAG/data/BIOMD0000000062.txt b/BioModelsRAG/data/BIOMD0000000062.txt deleted file mode 100644 index 2d9b124a9e1e8e67f3f0394d266f30585835822f..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000062.txt +++ /dev/null @@ -1,111 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Bhartiya2003_Tryptophan_operon() - - // Compartments and Species: - compartment compartment_; - species Enz in compartment_, Ts in compartment_, $Tt in compartment_, $To in compartment_; - - // Assignment Rules: - Tt := To + Ts; - To := Tomax*Tex/(Tex*(1 + Ts/f_val) + e_val); - Ts_norm := Ts/82; - To_norm := To/82; - Tt_norm := Tt/82; - Enz_norm := Enz/1; - - // Reactions: - Enzyme_synthesis: -> Enz; compartment_*Enzyme_synthesis_k1*Enzyme_synthesis_ki1^Enzyme_synthesis_nH*Enzyme_synthesis_Ot/(Enzyme_synthesis_ki1^Enzyme_synthesis_nH + Tt^Enzyme_synthesis_nH); - Enzyme_dilution: Enz -> ; compartment_*Enzyme_dilution_mu*Enz; - tryptophan_synthesis: -> Ts; compartment_*tryptophan_synthesis_k2*Enz*tryptophan_synthesis_Ki2/(tryptophan_synthesis_Ki2 + Tt); - tryptophan_consumption: Ts -> ; compartment_*tryptophan_consumption_g*Ts/(tryptophan_consumption_Kg + Ts); - tryptophan_dilution: Ts -> ; compartment_*tryptophan_dilution_mu*Ts; - - // Species initializations: - Enz = 0; - Ts = 0; - - // Compartment initializations: - compartment_ = 1; - - // Variable initializations: - Tomax = 100; - Tomax has concentration; - Tex = 0.14; - Tex has concentration; - f_val = 380; - f_val has concentration; - e_val = 0.9; - e_val has concentration; - Ts_norm has dimensionless; - To_norm has dimensionless; - Tt_norm has dimensionless; - Enz_norm has dimensionless; - Enzyme_synthesis_k1 = 65; - Enzyme_synthesis_k1 has time_inverse; - Enzyme_synthesis_ki1 = 3.53; - Enzyme_synthesis_ki1 has concentration; - Enzyme_synthesis_nH = 1.92; - Enzyme_synthesis_nH has dimensionless; - Enzyme_synthesis_Ot = 0.0033; - Enzyme_synthesis_Ot has concentration; - Enzyme_dilution_mu = 0.01; - Enzyme_dilution_mu has time_inverse; - tryptophan_synthesis_k2 = 25; - tryptophan_synthesis_k2 has time_inverse; - tryptophan_synthesis_Ki2 = 810; - tryptophan_synthesis_Ki2 has concentration; - tryptophan_consumption_g = 25; - tryptophan_consumption_g has Concentration_per_time; - tryptophan_consumption_Kg = 0.2; - tryptophan_consumption_Kg has concentration; - tryptophan_dilution_mu = 0.01; - tryptophan_dilution_mu has time_inverse; - - // Other declarations: - var Ts_norm, To_norm, Tt_norm, Enz_norm; - const compartment_, Tomax, Tex, f_val, e_val; - - // Unit definitions: - unit substance = 1e-6 mole; - unit time_unit = 60 second; - unit concentration = 1e-6 mole / litre; - unit Concentration_per_time = 1e-6 mole / (litre * 60 second); - unit time_inverse = 1 / 60 second; - - // Display Names: - substance is "micromole"; - time_unit is "minutes"; - concentration is "microM"; - Concentration_per_time is "microM_per_min"; - time_inverse is "per_min"; - compartment_ is "cell"; - Enz is "Anthranilate synthase"; - Ts is "Synthesized tryptophan"; - Tt is "Total tryptophan"; - To is "exog. Trp"; - Enzyme_synthesis is "Anthranilate synthase synthesis"; - Enzyme_dilution is "Enzyme dilution due to cell growth"; - tryptophan_synthesis is "Tryptophan synthesis"; - tryptophan_consumption is "Tryptophan consumption for protein synthesis"; - tryptophan_dilution is "Tryptophan dilution due to cell growth"; - - // CV terms: - compartment_ hypernym "http://identifiers.org/go/GO:0005623" - Enz identity "http://identifiers.org/uniprot/P00895" - Ts identity "http://identifiers.org/chebi/CHEBI:27897", - "http://identifiers.org/kegg.compound/C00806" - Tt identity "http://identifiers.org/chebi/CHEBI:27897", - "http://identifiers.org/kegg.compound/C00806" - Enzyme_synthesis hypernym "http://identifiers.org/go/GO:0006417" - tryptophan_synthesis hypernym "http://identifiers.org/go/GO:0000162" - tryptophan_consumption hypernym "http://identifiers.org/go/GO:0006412" -end - -Bhartiya2003_Tryptophan_operon is "Bhartiya2003_Tryptophan_operon" - -Bhartiya2003_Tryptophan_operon model_entity_is "http://identifiers.org/biomodels.db/MODEL6624111460" -Bhartiya2003_Tryptophan_operon model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000062" -Bhartiya2003_Tryptophan_operon description "http://identifiers.org/pubmed/12787031" -Bhartiya2003_Tryptophan_operon origin "http://identifiers.org/pubmed/11171956" -Bhartiya2003_Tryptophan_operon hypernym "http://identifiers.org/go/GO:0000162" -Bhartiya2003_Tryptophan_operon taxon "http://identifiers.org/taxonomy/562" diff --git a/BioModelsRAG/data/BIOMD0000000063.txt b/BioModelsRAG/data/BIOMD0000000063.txt deleted file mode 100644 index da82a5791cc403bb6b65d86bcf5f0f49ddc28e5b..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000063.txt +++ /dev/null @@ -1,267 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Galazzo1990_FermentationPathwayKinetics() - - // Compartments and Species: - compartment extracellular, cytoplasm; - species Glci in cytoplasm, ATP in cytoplasm, G6P in cytoplasm, FDP in cytoplasm; - species PEP in cytoplasm, $Gly in cytoplasm, $EtOH in cytoplasm, $Carbo in cytoplasm; - species $Glco in extracellular; - - // Assignment Rules: - VappGly := parameter_4*G6P^parameter_5/(parameter_6^parameter_5 + G6P^parameter_5); - VratioVmax := Vhk/(cytoplasm*parameter_7); - - // Reactions: - Vhk: ATP + Glci -> G6P; cytoplasm*Vhk_Vm2/(1 + Vhk_Km2Glc/Glci + Vhk_Km2ATP/ATP + Vhk_Ks2Glc*Vhk_Km2ATP/(Glci*ATP)); - Vin: $Glco -> Glci; cytoplasm*(Vin_Vm1 - Vin_Ki1G6P*G6P); - Vpol: ATP + G6P -> $Carbo; cytoplasm*1.1*Vpol_Vm3*G6P^Vpol_n3/(Vpol_K3Gly^Vpol_n3 + G6P^Vpol_n3)/(1 + (Vpol_Km30/0.7)*(1 + Vpol_Km3G6P/G6P)); - Vpfk: ATP + G6P -> FDP; ((cytoplasm*Vpfk_Vm4*Vpfk_g4R*0.3*G6P/Vpfk_K4F6P)*ATP/Vpfk_K4ATP)*(1 + 0.3*G6P/Vpfk_K4F6P + ATP/Vpfk_K4ATP + (Vpfk_g4R*0.3*G6P/Vpfk_K4F6P)*ATP/Vpfk_K4ATP)/((1 + 0.3*G6P/Vpfk_K4F6P + ATP/Vpfk_K4ATP + (Vpfk_g4R*0.3*G6P/Vpfk_K4F6P)*ATP/Vpfk_K4ATP)^2 + Vpfk_L40*((1 + Vpfk_c4AMP*(3 - ATP - 0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5))/Vpfk_K4AMP)/(1 + (3 - ATP - 0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5))/Vpfk_K4AMP))^2*(1 + Vpfk_c4F6P*0.3*G6P/Vpfk_K4F6P + Vpfk_c4ATP*ATP/Vpfk_K4ATP + (Vpfk_gT*Vpfk_c4F6P*0.3*G6P/Vpfk_K4F6P)*Vpfk_c4ATP*ATP/Vpfk_K4ATP)^2); - Vgapd: FDP -> 2 ATP + 2 PEP; cytoplasm*Vgapd_Vm5/(1 + Vgapd_K5G3P/(0.01*FDP) + (Vgapd_K5NAD/Vgapd_NAD + Vgapd_K5G3P*Vgapd_K5NAD/(Vgapd_NAD*0.01*FDP) + Vgapd_K5G3P*Vgapd_K5NAD*Vgapd_NADH/(Vgapd_NAD*0.01*FDP*Vgapd_K5NADH))*(1 + 0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vgapd_K5ADP + (3 - ATP - 0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5))/Vgapd_K5AMP + ATP/Vgapd_K5ATP)); - Vpk: PEP -> ATP + $EtOH; cytoplasm*Vpk_Vm6*((PEP/Vpk_K6PEP)*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vpk_K6ADP)*(Vpk_g6R*(1 + PEP/Vpk_K6PEP + 0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vpk_K6ADP + (Vpk_g6R*PEP/Vpk_K6PEP)*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vpk_K6ADP) + ((Vpk_q6*Vpk_L60*((1 + Vpk_c6FDP*FDP/Vpk_K6FDP)/(1 + FDP/Vpk_K6FDP))^2*Vpk_g6T*Vpk_c6PEP*PEP/Vpk_K6PEP)*Vpk_c6ADP*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vpk_K6ADP)*(1 + Vpk_c6PEP*PEP/Vpk_K6PEP + Vpk_c6ADP*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vpk_K6ADP + (Vpk_g6T*Vpk_c6PEP*PEP/Vpk_K6PEP)*Vpk_c6ADP*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vpk_K6ADP))/((1 + 9.55*10^-9/Vpk_h6)*((1 + PEP/Vpk_K6PEP + 0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vpk_K6ADP + (Vpk_g6R*PEP/Vpk_K6PEP)*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vpk_K6ADP)^2 + Vpk_L60*((1 + Vpk_c6FDP*FDP/Vpk_K6FDP)/(1 + FDP/Vpk_K6FDP))^2*(1 + Vpk_c6PEP*PEP/Vpk_K6PEP + Vpk_c6ADP*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vpk_K6ADP + (Vpk_g6T*Vpk_c6PEP*PEP/Vpk_K6PEP)*Vpk_c6ADP*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vpk_K6ADP)^2)); - Vgol: 0.5 FDP -> $Gly; Vgol_Vm7*cytoplasm*((PEP/Vgol_K6PEP)*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vgol_K6ADP)*(Vgol_g6R*(1 + PEP/Vgol_K6PEP + 0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vgol_K6ADP + (Vgol_g6R*PEP/Vgol_K6PEP)*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vgol_K6ADP) + ((Vgol_q6*Vgol_L60*((1 + Vgol_c6FDP*FDP/Vgol_K6FDP)/(1 + FDP/Vgol_K6FDP))^2*Vgol_g6T*Vgol_c6PEP*PEP/Vgol_K6PEP)*Vgol_c6ADP*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vgol_K6ADP)*(1 + Vgol_c6PEP*PEP/Vgol_K6PEP + Vgol_c6ADP*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vgol_K6ADP + (Vgol_g6T*Vgol_c6PEP*PEP/Vgol_K6PEP)*Vgol_c6ADP*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vgol_K6ADP))/((1 + 9.55*10^-9/Vgol_h6)*((1 + PEP/Vgol_K6PEP + 0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vgol_K6ADP + (Vgol_g6R*PEP/Vgol_K6PEP)*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vgol_K6ADP)^2 + Vgol_L60*((1 + Vgol_c6FDP*FDP/Vgol_K6FDP)/(1 + FDP/Vgol_K6FDP))^2*(1 + Vgol_c6PEP*PEP/Vgol_K6PEP + Vgol_c6ADP*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vgol_K6ADP + (Vgol_g6T*Vgol_c6PEP*PEP/Vgol_K6PEP)*Vgol_c6ADP*0.5*(-ATP + (12*ATP - 3*ATP^2)^0.5)/Vgol_K6ADP)^2)); - Vatpase: ATP -> ; cytoplasm*Vatpase_Vm8*ATP; - - // Species initializations: - Glci = 0.0345; - ATP = 1.19; - G6P = 1.011; - FDP = 9.144; - PEP = 0.0095; - Gly = 0; - EtOH = 0; - Carbo = 0; - Glco = 1; - - // Compartment initializations: - extracellular = 1; - cytoplasm = 1; - VappGly has mM_per_minute; - - // Variable initializations: - parameter_4 = 14.31; - parameter_4 has mM_per_minute; - parameter_5 = 8.25; - parameter_5 has dimensionless; - parameter_6 = 2; - parameter_6 has mM; - VratioVmax has dimensionless; - parameter_7 = 68.5; - parameter_7 has mM_per_minute; - Vin_Vm1 = 19.7; - Vin_Vm1 has mM_per_minute; - Vin_Ki1G6P = 3.7; - Vin_Ki1G6P has min_inv; - Vhk_Vm2 = 68.5; - Vhk_Vm2 has mM_per_minute; - Vhk_Km2Glc = 0.11; - Vhk_Km2Glc has mM; - Vhk_Km2ATP = 0.1; - Vhk_Km2ATP has mM; - Vhk_Ks2Glc = 0.0062; - Vhk_Ks2Glc has mM; - Vpol_Vm3 = 14.31; - Vpol_Vm3 has mM_per_minute; - Vpol_n3 = 8.25; - Vpol_n3 has dimensionless; - Vpol_K3Gly = 2; - Vpol_K3Gly has mM; - Vpol_Km30 = 1; - Vpol_Km30 has mM; - Vpol_Km3G6P = 1.1; - Vpol_Km3G6P has mM; - Vpfk_Vm4 = 31.7; - Vpfk_Vm4 has mM_per_minute; - Vpfk_g4R = 10; - Vpfk_g4R has dimensionless; - Vpfk_K4F6P = 1; - Vpfk_K4F6P has mM; - Vpfk_K4ATP = 0.06; - Vpfk_K4ATP has mM; - Vpfk_L40 = 3342; - Vpfk_L40 has dimensionless; - Vpfk_c4AMP = 0.019; - Vpfk_c4AMP has dimensionless; - Vpfk_K4AMP = 0.025; - Vpfk_K4AMP has mM; - Vpfk_c4F6P = 0.0005; - Vpfk_c4F6P has dimensionless; - Vpfk_c4ATP = 1; - Vpfk_c4ATP has dimensionless; - Vpfk_gT = 1; - Vpfk_gT has dimensionless; - Vgapd_Vm5 = 49.9; - Vgapd_Vm5 has mM_per_minute; - Vgapd_K5G3P = 0.0025; - Vgapd_K5G3P has mM; - Vgapd_K5NAD = 0.18; - Vgapd_K5NAD has dimensionless; - Vgapd_NAD = 1.91939; - Vgapd_NAD has mM; - Vgapd_NADH = 0.0806142; - Vgapd_NADH has mM; - Vgapd_K5NADH = 0.0003; - Vgapd_K5NADH has mM; - Vgapd_K5ADP = 1.5; - Vgapd_K5ADP has mM; - Vgapd_K5AMP = 1.1; - Vgapd_K5AMP has mM; - Vgapd_K5ATP = 2.5; - Vgapd_K5ATP has mM; - Vpk_Vm6 = 3440; - Vpk_Vm6 has mM_per_minute; - Vpk_K6PEP = 0.00793966; - Vpk_K6PEP has mM; - Vpk_K6ADP = 5; - Vpk_K6ADP has mM; - Vpk_g6R = 0.1; - Vpk_g6R has dimensionless; - Vpk_q6 = 1; - Vpk_q6 has dimensionless; - Vpk_L60 = 164.084; - Vpk_L60 has dimensionless; - Vpk_c6FDP = 0.01; - Vpk_c6FDP has dimensionless; - Vpk_K6FDP = 0.2; - Vpk_K6FDP has mM; - Vpk_g6T = 1; - Vpk_g6T has dimensionless; - Vpk_c6PEP = 0.000158793; - Vpk_c6PEP has dimensionless; - Vpk_c6ADP = 1; - Vpk_c6ADP has dimensionless; - Vpk_h6 = 1.14815e-07; - Vpk_h6 has dimensionless; - Vgol_Vm7 = 203; - Vgol_Vm7 has mM_per_minute; - Vgol_K6PEP = 0.00793966; - Vgol_K6PEP has mM; - Vgol_K6ADP = 5; - Vgol_K6ADP has mM; - Vgol_g6R = 0.1; - Vgol_g6R has dimensionless; - Vgol_q6 = 1; - Vgol_q6 has dimensionless; - Vgol_L60 = 164.084; - Vgol_L60 has dimensionless; - Vgol_c6FDP = 0.01; - Vgol_c6FDP has dimensionless; - Vgol_K6FDP = 0.2; - Vgol_K6FDP has mM; - Vgol_g6T = 1; - Vgol_g6T has dimensionless; - Vgol_c6PEP = 0.000158793; - Vgol_c6PEP has dimensionless; - Vgol_c6ADP = 1; - Vgol_c6ADP has dimensionless; - Vgol_h6 = 1.14815e-07; - Vgol_h6 has dimensionless; - Vatpase_Vm8 = 25.1; - Vatpase_Vm8 has min_inv; - - // Other declarations: - var VappGly, VratioVmax; - const extracellular, cytoplasm, parameter_4, parameter_5, parameter_6, parameter_7; - - // Unit definitions: - unit substance = 1e-3 mole; - unit time_unit = 60 second; - unit mM = 1e-3 mole / litre; - unit mM_per_minute = 1e-3 mole / (litre * 60 second); - unit min_inv = 1 / 60 second; - - // Display Names: - substance is "millimole"; - time_unit is "minute"; - mM is "milliMolar"; - mM_per_minute is "mM per minute"; - min_inv is "minute_inverse"; - extracellular is "Extracellular"; - cytoplasm is "Cytoplasm"; - Glci is "Glucose inside the cell"; - G6P is "Glucose 6-phosphate"; - FDP is "Fructose 1,6-phosphate"; - PEP is "Phosphoenol pyruvate"; - Gly is "Glycerol"; - EtOH is "Ethanol"; - Carbo is "Glycogen and Trehalose"; - Glco is "Glucose outside the cell"; - parameter_4 is "Trehalose and Glycogen formation_Vm3"; - parameter_5 is "Trehalose and Glycogen formation_n3"; - parameter_6 is "Trehalose and Glycogen formation_K3Gly"; - VratioVmax is "VratioVmax_ATP"; - Vhk is "Hexokinase"; - parameter_7 is "Hexokinase_Vm2"; - Vin is "Glucose in"; - Vpol is "Trehalose and Glycogen formation"; - Vpfk is "Phosphofructokinase"; - Vgapd is "GAPD"; - Vpk is "Pyruvate kinase"; - Vgol is "Glycerol synthesis"; - Vatpase is "ATPase"; - - // CV terms: - extracellular identity "http://identifiers.org/go/GO:0005576" - cytoplasm identity "http://identifiers.org/go/GO:0005737" - Glci identity "http://identifiers.org/chebi/CHEBI:17234", - "http://identifiers.org/kegg.compound/C00293" - ATP identity "http://identifiers.org/chebi/CHEBI:15422", - "http://identifiers.org/kegg.compound/C00002" - G6P identity "http://identifiers.org/chebi/CHEBI:17665", - "http://identifiers.org/kegg.compound/C00668" - FDP identity "http://identifiers.org/chebi/CHEBI:16905", - "http://identifiers.org/kegg.compound/C00354" - PEP identity "http://identifiers.org/chebi/CHEBI:18021", - "http://identifiers.org/kegg.compound/C00074" - Gly identity "http://identifiers.org/chebi/CHEBI:17754", - "http://identifiers.org/kegg.compound/C00116" - EtOH identity "http://identifiers.org/chebi/CHEBI:16236", - "http://identifiers.org/kegg.compound/C00469" - Carbo part "http://identifiers.org/chebi/CHEBI:28087", - "http://identifiers.org/chebi/CHEBI:27082" - Carbo part "http://identifiers.org/kegg.compound/C00182", - "http://identifiers.org/kegg.compound/C01083", - "http://identifiers.org/chebi/CHEBI:28087" - Glco identity "http://identifiers.org/chebi/CHEBI:17234", - "http://identifiers.org/kegg.compound/C00293" - Vhk homolog "http://identifiers.org/reactome/REACT_1318" - Vhk identity "http://identifiers.org/ec-code/2.7.1.2", - "http://identifiers.org/kegg.reaction/R00299" - Vin homolog "http://identifiers.org/reactome/REACT_2092" - Vin identity "http://identifiers.org/go/GO:0046323" - Vpol homolog "http://identifiers.org/reactome/REACT_1736" - Vpol part "http://identifiers.org/go/GO:0005978", - "http://identifiers.org/go/GO:0005992" - Vpfk part "http://identifiers.org/reactome/REACT_736", - "http://identifiers.org/reactome/REACT_1164" - Vpfk part "http://identifiers.org/kegg.reaction/R00771", - "http://identifiers.org/kegg.reaction/R00756" - Vgapd part "http://identifiers.org/kegg.reaction/R00658", - "http://identifiers.org/kegg.reaction/R01518", - "http://identifiers.org/kegg.reaction/R01512", - "http://identifiers.org/kegg.reaction/R01061", - "http://identifiers.org/kegg.reaction/R01015", - "http://identifiers.org/kegg.reaction/R01070" - Vgapd part "http://identifiers.org/ec-code/2.7.2.3", - "http://identifiers.org/ec-code/5.4.2.1", - "http://identifiers.org/ec-code/1.2.1.12", - "http://identifiers.org/ec-code/5.3.1.1", - "http://identifiers.org/ec-code/4.1.2.13", - "http://identifiers.org/ec-code/4.2.1.11" - Vpk hypernym "http://identifiers.org/go/GO:0043458" - Vpk identity "http://identifiers.org/ec-code/2.7.1.40" - Vgol hypernym "http://identifiers.org/go/GO:0006114" - Vatpase hypernym "http://identifiers.org/ec-code/3.6.1.3", - "http://identifiers.org/go/GO:0016887" -end - -Galazzo1990_FermentationPathwayKinetics is "Galazzo1990_FermentationPathwayKinetics" - -Galazzo1990_FermentationPathwayKinetics model_entity_is "http://identifiers.org/biomodels.db/MODEL6624154196" -Galazzo1990_FermentationPathwayKinetics model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000063" -Galazzo1990_FermentationPathwayKinetics description "http://identifiers.org/doi/10.1016/0141-0229(90)90033-M" -Galazzo1990_FermentationPathwayKinetics homolog "http://identifiers.org/reactome/REACT_723" -Galazzo1990_FermentationPathwayKinetics identity "http://identifiers.org/kegg.pathway/sce00010" -Galazzo1990_FermentationPathwayKinetics hypernym "http://identifiers.org/go/GO:0019660" -Galazzo1990_FermentationPathwayKinetics property "http://identifiers.org/mamo/MAMO_0000046" -Galazzo1990_FermentationPathwayKinetics taxon "http://identifiers.org/taxonomy/4932" -Galazzo1990_FermentationPathwayKinetics part "http://identifiers.org/go/GO:0006096" diff --git a/BioModelsRAG/data/BIOMD0000000064.txt b/BioModelsRAG/data/BIOMD0000000064.txt deleted file mode 100644 index ac7e5c3e0afc5bf1749bf4ec5bb0d86c006c54fe..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000064.txt +++ /dev/null @@ -1,434 +0,0 @@ -// Created by libAntimony v2.13.0 -function L_PFK(L, CiATP, KiATP, CAMP, KAMP, CF26BP, KF26BP, CF16BP, KF16BP, AT, AM, F16, F26) - L*((1 + CiATP*(AT/KiATP))/(1 + AT/KiATP))^2*((1 + CAMP*(AM/KAMP))/(1 + AM/KAMP))^2*((1 + CF26BP*F26/KF26BP + CF16BP*F16/KF16BP)/(1 + F26/KF26BP + F16/KF16BP))^2; -end - -L_PFK is "L_PFK" - -function R_PFK(KmF6P, KmATP, g, AT, F6) - 1 + F6/KmF6P + AT/KmATP + g*(F6/KmF6P)*(AT/KmATP); -end - -R_PFK is "R_PFK" - -function T_PFK(CATP, KmATP, AT) - 1 + CATP*(AT/KmATP); -end - -T_PFK is "T_PFK" - - -model *Teusink2000_Glycolysis() - - // Compartments and Species: - compartment extracellular, cytosol; - species GLCi in cytosol, G6P in cytosol, F6P in cytosol, F16P in cytosol; - species TRIO in cytosol, BPG in cytosol, P3G in cytosol, P2G in cytosol; - species PEP in cytosol, PYR in cytosol, ACE in cytosol, P in cytosol, NAD in cytosol; - species NADH in cytosol, $Glyc in cytosol, $Trh in cytosol, $CO2 in cytosol; - species $SUCC in cytosol, $GLCo in extracellular, $ETOH in cytosol, $GLY in cytosol; - species $ATP in cytosol, $ADP in cytosol, $SUM_P in cytosol, $AMP in cytosol; - species $F26BP in cytosol; - - // Assignment Rules: - ATP := (P - ADP)/2; - ADP := (SUM_P - (P^2*(1 - 4*KeqAK) + 2*SUM_P*P*(4*KeqAK - 1) + SUM_P^2)^0.5)/(1 - 4*KeqAK); - AMP := SUM_P - ATP - ADP; - - // Reactions: - vGLK: GLCi + P -> G6P; (cytosol*vGLK_VmGLK/(vGLK_KmGLKGLCi*vGLK_KmGLKATP))*(GLCi*ATP - G6P*ADP/vGLK_KeqGLK)/((1 + GLCi/vGLK_KmGLKGLCi + G6P/vGLK_KmGLKG6P)*(1 + ATP/vGLK_KmGLKATP + ADP/vGLK_KmGLKADP)); - vPGI: G6P -> F6P; (cytosol*vPGI_VmPGI_2/vPGI_KmPGIG6P_2)*(G6P - F6P/vPGI_KeqPGI_2)/(1 + G6P/vPGI_KmPGIG6P_2 + F6P/vPGI_KmPGIF6P_2); - vGLYCO: G6P + P => $Glyc; cytosol*vGLYCO_KGLYCOGEN_3; - vTreha: 2 G6P + P => $Trh; cytosol*vTreha_KTREHALOSE; - vPFK: F6P + P => F16P; cytosol*vPFK_VmPFK*gR*(F6P/KmPFKF6P)*(ATP/KmPFKATP)*R_PFK(KmPFKF6P, KmPFKATP, gR, ATP, F6P)/(R_PFK(KmPFKF6P, KmPFKATP, gR, ATP, F6P)^2 + L_PFK(Lzero, CiPFKATP, KiPFKATP, CPFKAMP, KPFKAMP, CPFKF26BP, KPFKF26BP, CPFKF16BP, KPFKF16BP, ATP, AMP, F16P, F26BP)*T_PFK(CPFKATP, KmPFKATP, ATP)^2); - vALD: F16P -> 2 TRIO; (cytosol*vALD_VmALD/vALD_KmALDF16P)*(F16P - (KeqTPI/(1 + KeqTPI))*TRIO*(1/(1 + KeqTPI))*TRIO/vALD_KeqALD)/(1 + F16P/vALD_KmALDF16P + (KeqTPI/(1 + KeqTPI))*TRIO/vALD_KmALDGAP + (1/(1 + KeqTPI))*TRIO/vALD_KmALDDHAP + (KeqTPI/(1 + KeqTPI))*TRIO*(1/(1 + KeqTPI))*TRIO/(vALD_KmALDGAP*vALD_KmALDDHAP) + F16P*(KeqTPI/(1 + KeqTPI))*TRIO/(vALD_KmALDGAPi*vALD_KmALDF16P)); - vGAPDH: TRIO + NAD -> BPG + NADH; cytosol*(vGAPDH_VmGAPDHf*(KeqTPI/(1 + KeqTPI))*TRIO*NAD/(vGAPDH_KmGAPDHGAP*vGAPDH_KmGAPDHNAD) - vGAPDH_VmGAPDHr*BPG*NADH/(vGAPDH_KmGAPDHBPG*vGAPDH_KmGAPDHNADH))/((1 + (KeqTPI/(1 + KeqTPI))*TRIO/vGAPDH_KmGAPDHGAP + BPG/vGAPDH_KmGAPDHBPG)*(1 + NAD/vGAPDH_KmGAPDHNAD + NADH/vGAPDH_KmGAPDHNADH)); - vPGK: BPG -> P3G + P; (cytosol*vPGK_VmPGK/(vPGK_KmPGKP3G*vPGK_KmPGKATP))*(vPGK_KeqPGK*BPG*ADP - P3G*ATP)/((1 + BPG/vPGK_KmPGKBPG + P3G/vPGK_KmPGKP3G)*(1 + ATP/vPGK_KmPGKATP + ADP/vPGK_KmPGKADP)); - vPGM: P3G -> P2G; (cytosol*vPGM_VmPGM/vPGM_KmPGMP3G)*(P3G - P2G/vPGM_KeqPGM)/(1 + P3G/vPGM_KmPGMP3G + P2G/vPGM_KmPGMP2G); - vENO: P2G -> PEP; (cytosol*vENO_VmENO/vENO_KmENOP2G)*(P2G - PEP/vENO_KeqENO)/(1 + P2G/vENO_KmENOP2G + PEP/vENO_KmENOPEP); - vPYK: PEP -> PYR + P; (cytosol*vPYK_VmPYK/(vPYK_KmPYKPEP*vPYK_KmPYKADP))*(PEP*ADP - PYR*ATP/vPYK_KeqPYK)/((1 + PEP/vPYK_KmPYKPEP + PYR/vPYK_KmPYKPYR)*(1 + ATP/vPYK_KmPYKATP + ADP/vPYK_KmPYKADP)); - vPDC: PYR => ACE + $CO2; cytosol*vPDC_VmPDC*(PYR^vPDC_nPDC/vPDC_KmPDCPYR^vPDC_nPDC)/(1 + PYR^vPDC_nPDC/vPDC_KmPDCPYR^vPDC_nPDC); - vSUC: 2 ACE + 3 NAD + 4 P => 3 NADH + $SUCC; cytosol*vSUC_KSUCC*ACE; - vGLT: $GLCo -> GLCi; (vGLT_VmGLT/vGLT_KmGLTGLCo)*(GLCo - GLCi/vGLT_KeqGLT)/(1 + GLCo/vGLT_KmGLTGLCo + GLCi/vGLT_KmGLTGLCi + 0.91*GLCo*GLCi/(vGLT_KmGLTGLCo*vGLT_KmGLTGLCi)); - vADH: ACE + NADH -> NAD + $ETOH; -cytosol*((vADH_VmADH/(vADH_KiADHNAD*vADH_KmADHETOH))*(NAD*ETOH - NADH*ACE/vADH_KeqADH)/(1 + NAD/vADH_KiADHNAD + vADH_KmADHNAD*ETOH/(vADH_KiADHNAD*vADH_KmADHETOH) + vADH_KmADHNADH*ACE/(vADH_KiADHNADH*vADH_KmADHACE) + NADH/vADH_KiADHNADH + NAD*ETOH/(vADH_KiADHNAD*vADH_KmADHETOH) + vADH_KmADHNADH*NAD*ACE/(vADH_KiADHNAD*vADH_KiADHNADH*vADH_KmADHACE) + vADH_KmADHNAD*ETOH*NADH/(vADH_KiADHNAD*vADH_KmADHETOH*vADH_KiADHNADH) + NADH*ACE/(vADH_KiADHNADH*vADH_KmADHACE) + NAD*ETOH*ACE/(vADH_KiADHNAD*vADH_KmADHETOH*vADH_KiADHACE) + ETOH*NADH*ACE/(vADH_KiADHETOH*vADH_KiADHNADH*vADH_KmADHACE))); - vG3PDH: TRIO + NADH => NAD + $GLY; (cytosol*vG3PDH_VmG3PDH/(vG3PDH_KmG3PDHDHAP*vG3PDH_KmG3PDHNADH))*((1/(1 + KeqTPI))*TRIO*NADH - GLY*NAD/vG3PDH_KeqG3PDH)/((1 + (1/(1 + KeqTPI))*TRIO/vG3PDH_KmG3PDHDHAP + GLY/vG3PDH_KmG3PDHGLY)*(1 + NADH/vG3PDH_KmG3PDHNADH + NAD/vG3PDH_KmG3PDHNAD)); - vATP: P -> ; cytosol*vATP_KATPASE*ATP; - - // Species initializations: - GLCi = 0.087; - G6P = 2.45; - F6P = 0.62; - F16P = 5.51; - TRIO = 0.96; - BPG = 0; - P3G = 0.9; - P2G = 0.12; - PEP = 0.07; - PYR = 1.85; - ACE = 0.17; - P = 6.31; - NAD = 1.2; - NADH = 0.39; - Glyc = 0; - Trh = 0; - CO2 = 1; - SUCC = 0; - GLCo = 50; - ETOH = 50; - GLY = 0.15; - SUM_P = 4.1; - F26BP = 0.02; - - // Compartment initializations: - extracellular = 1; - cytosol = 1; - - // Variable initializations: - KeqAK = 0.45; - KeqAK has dimensionless; - gR = 5.12; - gR has dimensionless; - KmPFKF6P = 0.1; - KmPFKF6P has mM; - KmPFKATP = 0.71; - KmPFKATP has mM; - Lzero = 0.66; - Lzero has dimensionless; - CiPFKATP = 100; - CiPFKATP has dimensionless; - KiPFKATP = 0.65; - KiPFKATP has mM; - CPFKAMP = 0.0845; - CPFKAMP has dimensionless; - KPFKAMP = 0.0995; - KPFKAMP has mM; - CPFKF26BP = 0.0174; - CPFKF26BP has dimensionless; - KPFKF26BP = 0.000682; - KPFKF26BP has mM; - CPFKF16BP = 0.397; - CPFKF16BP has dimensionless; - KPFKF16BP = 0.111; - KPFKF16BP has mM; - CPFKATP = 3; - CPFKATP has dimensionless; - KeqTPI = 0.045; - KeqTPI has dimensionless; - vGLK_VmGLK = 226.452; - vGLK_VmGLK has mMpermin; - vGLK_KmGLKGLCi = 0.08; - vGLK_KmGLKGLCi has mM; - vGLK_KmGLKATP = 0.15; - vGLK_KmGLKATP has mM; - vGLK_KeqGLK = 3800; - vGLK_KeqGLK has dimensionless; - vGLK_KmGLKG6P = 30; - vGLK_KmGLKG6P has mM; - vGLK_KmGLKADP = 0.23; - vGLK_KmGLKADP has mM; - vPGI_VmPGI_2 = 339.677; - vPGI_VmPGI_2 has mMpermin; - vPGI_KmPGIG6P_2 = 1.4; - vPGI_KmPGIG6P_2 has mM; - vPGI_KeqPGI_2 = 0.314; - vPGI_KeqPGI_2 has dimensionless; - vPGI_KmPGIF6P_2 = 0.3; - vPGI_KmPGIF6P_2 has mM; - vGLYCO_KGLYCOGEN_3 = 6; - vGLYCO_KGLYCOGEN_3 has mMpermin; - vTreha_KTREHALOSE = 2.4; - vTreha_KTREHALOSE has mMpermin; - vPFK_VmPFK = 182.903; - vPFK_VmPFK has mMpermin; - vALD_VmALD = 322.258; - vALD_VmALD has mMpermin; - vALD_KmALDF16P = 0.3; - vALD_KmALDF16P has mM; - vALD_KeqALD = 0.069; - vALD_KeqALD has dimensionless; - vALD_KmALDGAP = 2; - vALD_KmALDGAP has mM; - vALD_KmALDDHAP = 2.4; - vALD_KmALDDHAP has mM; - vALD_KmALDGAPi = 10; - vALD_KmALDGAPi has mM; - vGAPDH_VmGAPDHf = 1184.52; - vGAPDH_VmGAPDHf has mMpermin; - vGAPDH_KmGAPDHGAP = 0.21; - vGAPDH_KmGAPDHGAP has mM; - vGAPDH_KmGAPDHNAD = 0.09; - vGAPDH_KmGAPDHNAD has mM; - vGAPDH_VmGAPDHr = 6549.8; - vGAPDH_VmGAPDHr has mMpermin; - vGAPDH_KmGAPDHBPG = 0.0098; - vGAPDH_KmGAPDHBPG has mM; - vGAPDH_KmGAPDHNADH = 0.06; - vGAPDH_KmGAPDHNADH has mM; - vPGK_VmPGK = 1306.45; - vPGK_VmPGK has mMpermin; - vPGK_KmPGKP3G = 0.53; - vPGK_KmPGKP3G has mM; - vPGK_KmPGKATP = 0.3; - vPGK_KmPGKATP has mM; - vPGK_KeqPGK = 3200; - vPGK_KeqPGK has dimensionless; - vPGK_KmPGKBPG = 0.003; - vPGK_KmPGKBPG has mM; - vPGK_KmPGKADP = 0.2; - vPGK_KmPGKADP has mM; - vPGM_VmPGM = 2525.81; - vPGM_VmPGM has mMpermin; - vPGM_KmPGMP3G = 1.2; - vPGM_KmPGMP3G has mM; - vPGM_KeqPGM = 0.19; - vPGM_KeqPGM has dimensionless; - vPGM_KmPGMP2G = 0.08; - vPGM_KmPGMP2G has mM; - vENO_VmENO = 365.806; - vENO_VmENO has mMpermin; - vENO_KmENOP2G = 0.04; - vENO_KmENOP2G has mM; - vENO_KeqENO = 6.7; - vENO_KeqENO has dimensionless; - vENO_KmENOPEP = 0.5; - vENO_KmENOPEP has mM; - vPYK_VmPYK = 1088.71; - vPYK_VmPYK has mMpermin; - vPYK_KmPYKPEP = 0.14; - vPYK_KmPYKPEP has mM; - vPYK_KmPYKADP = 0.53; - vPYK_KmPYKADP has mM; - vPYK_KeqPYK = 6500; - vPYK_KeqPYK has dimensionless; - vPYK_KmPYKPYR = 21; - vPYK_KmPYKPYR has mM; - vPYK_KmPYKATP = 1.5; - vPYK_KmPYKATP has mM; - vPDC_VmPDC = 174.194; - vPDC_VmPDC has mMpermin; - vPDC_nPDC = 1.9; - vPDC_nPDC has dimensionless; - vPDC_KmPDCPYR = 4.33; - vPDC_KmPDCPYR has mM; - vSUC_KSUCC = 21.4; - vGLT_VmGLT = 97.264; - vGLT_VmGLT has mmolepermin; - vGLT_KmGLTGLCo = 1.1918; - vGLT_KmGLTGLCo has mM; - vGLT_KeqGLT = 1; - vGLT_KeqGLT has mM; - vGLT_KmGLTGLCi = 1.1918; - vGLT_KmGLTGLCi has mM; - vADH_VmADH = 810; - vADH_VmADH has mMpermin; - vADH_KiADHNAD = 0.92; - vADH_KiADHNAD has mM; - vADH_KmADHETOH = 17; - vADH_KmADHETOH has mM; - vADH_KeqADH = 6.9e-05; - vADH_KeqADH has dimensionless; - vADH_KmADHNAD = 0.17; - vADH_KmADHNAD has mM; - vADH_KmADHNADH = 0.11; - vADH_KmADHNADH has mM; - vADH_KiADHNADH = 0.031; - vADH_KiADHNADH has mM; - vADH_KmADHACE = 1.11; - vADH_KmADHACE has mM; - vADH_KiADHACE = 1.1; - vADH_KiADHACE has mM; - vADH_KiADHETOH = 90; - vADH_KiADHETOH has mM; - vG3PDH_VmG3PDH = 70.15; - vG3PDH_VmG3PDH has mMpermin; - vG3PDH_KmG3PDHDHAP = 0.4; - vG3PDH_KmG3PDHDHAP has mM; - vG3PDH_KmG3PDHNADH = 0.023; - vG3PDH_KmG3PDHNADH has mM; - vG3PDH_KeqG3PDH = 4300; - vG3PDH_KeqG3PDH has dimensionless; - vG3PDH_KmG3PDHGLY = 1; - vG3PDH_KmG3PDHGLY has mM; - vG3PDH_KmG3PDHNAD = 0.93; - vG3PDH_KmG3PDHNAD has mM; - vATP_KATPASE = 33.7; - vATP_KATPASE has permin; - - // Other declarations: - const extracellular, cytosol, KeqAK, gR, KmPFKF6P, KmPFKATP, Lzero, CiPFKATP; - const KiPFKATP, CPFKAMP, KPFKAMP, CPFKF26BP, KPFKF26BP, CPFKF16BP, KPFKF16BP; - const CPFKATP, KeqTPI; - - // Unit definitions: - unit substance = 1e-3 mole; - unit time_unit = 60 second; - unit mM = 1e-3 mole / litre; - unit mMpermin = 1e-3 mole / (litre * 60 second); - unit permin = 1 / 60 second; - unit mmolepermin = 1e-3 mole / 60 second; - - // Display Names: - substance is "millimole"; - time_unit is "minute"; - GLCi is "Glucose in Cytosol"; - G6P is "Glucose 6 Phosphate"; - F6P is "Fructose 6 Phosphate"; - F16P is "Fructose-1,6 bisphosphate"; - TRIO is "Triose-phosphate"; - BPG is "1,3-bisphosphoglycerate"; - P3G is "3-phosphoglycerate"; - P2G is "2-phosphoglycerate"; - PEP is "Phosphoenolpyruvate"; - PYR is "Pyruvate"; - ACE is "Acetaldehyde"; - P is "High energy phosphates"; - Glyc is "Glycogen"; - Trh is "Trehalose"; - SUCC is "Succinate"; - GLCo is "Extracellular Glucose"; - ETOH is "Ethanol"; - GLY is "Glycerol"; - ATP is "ATP concentration"; - ADP is "ADP concentration"; - SUM_P is "sum of AXP conc"; - KeqAK is "AK eq constant"; - AMP is "AMP concentration"; - F26BP is "F2,6P"; - KeqTPI is "TPI eq constant"; - vGLK is "Hexokinase"; - vPGI is "Glucose-6-phosphate isomerase"; - vGLYCO is "Glycogen synthesis"; - vTreha is "Trehalose 6-phosphate synthase"; - vPFK is "Phosphofructokinase"; - vALD is "Aldolase"; - vGAPDH is "Glyceraldehyde 3-phosphate dehydrogenase"; - vPGK is "Phosphoglycerate kinase"; - vPGM is "Phosphoglycerate mutase"; - vENO is "Enolase"; - vPYK is "Pyruvate kinase"; - vPDC is "Pyruvate decarboxylase"; - vSUC is "Succinate synthesis"; - vGLT is "Glucose transport"; - vADH is "Alcohol dehydrogenase"; - vG3PDH is "Glycerol 3-phosphate dehydrogenase"; - vATP is "ATPase activity"; - - // CV terms: - extracellular identity "http://identifiers.org/obo.go/GO:0005576" - cytosol identity "http://identifiers.org/obo.go/GO:0005829" - GLCi identity "http://identifiers.org/obo.chebi/CHEBI:17234", - "http://identifiers.org/kegg.compound/C00293" - G6P identity "http://identifiers.org/obo.chebi/CHEBI:17665", - "http://identifiers.org/kegg.compound/C00668" - F6P identity "http://identifiers.org/obo.chebi/CHEBI:15946", - "http://identifiers.org/kegg.compound/C05345" - F16P identity "http://identifiers.org/obo.chebi/CHEBI:16905", - "http://identifiers.org/kegg.compound/C00354" - TRIO part "http://identifiers.org/obo.chebi/CHEBI:16108", - "http://identifiers.org/obo.chebi/CHEBI:29052" - TRIO part "http://identifiers.org/kegg.compound/C00118", - "http://identifiers.org/kegg.compound/C00111", - "http://identifiers.org/chebi/CHEBI:29052" - BPG identity "http://identifiers.org/obo.chebi/CHEBI:16001", - "http://identifiers.org/kegg.compound/C00236" - P3G identity "http://identifiers.org/obo.chebi/CHEBI:17794", - "http://identifiers.org/kegg.compound/C00197" - P2G identity "http://identifiers.org/obo.chebi/CHEBI:17835", - "http://identifiers.org/kegg.compound/C00631" - PEP identity "http://identifiers.org/kegg.compound/C00074", - "http://identifiers.org/chebi/CHEBI:18021" - PEP identity "http://identifiers.org/obo.chebi/CHEBI:18021" - PYR identity "http://identifiers.org/obo.chebi/CHEBI:15361" - PYR identity "http://identifiers.org/kegg.compound/C00022", - "http://identifiers.org/chebi/CHEBI:32816" - ACE identity "http://identifiers.org/obo.chebi/CHEBI:15343", - "http://identifiers.org/kegg.compound/C00084" - P part "http://identifiers.org/kegg.compound/C00008", - "http://identifiers.org/kegg.compound/C00002", - "http://identifiers.org/chebi/CHEBI:16761" - P part "http://identifiers.org/obo.chebi/CHEBI:16761", - "http://identifiers.org/obo.chebi/CHEBI:15422" - NAD identity "http://identifiers.org/obo.chebi/CHEBI:15846", - "http://identifiers.org/kegg.compound/C00003" - NADH identity "http://identifiers.org/obo.chebi/CHEBI:16908", - "http://identifiers.org/kegg.compound/C00004" - Glyc identity "http://identifiers.org/obo.chebi/CHEBI:28087", - "http://identifiers.org/kegg.compound/C00182" - Trh identity "http://identifiers.org/obo.chebi/CHEBI:27082", - "http://identifiers.org/kegg.compound/C01083" - CO2 identity "http://identifiers.org/obo.chebi/CHEBI:16526", - "http://identifiers.org/kegg.compound/C00011" - SUCC identity "http://identifiers.org/obo.chebi/CHEBI:30031" - GLCo identity "http://identifiers.org/obo.chebi/CHEBI:17234", - "http://identifiers.org/kegg.compound/C00293" - ETOH identity "http://identifiers.org/obo.chebi/CHEBI:16236", - "http://identifiers.org/kegg.compound/C00469" - GLY identity "http://identifiers.org/obo.chebi/CHEBI:17754", - "http://identifiers.org/kegg.compound/C00116" - ATP identity "http://identifiers.org/obo.chebi/CHEBI:15422", - "http://identifiers.org/kegg.compound/C00002" - ADP identity "http://identifiers.org/obo.chebi/CHEBI:16761", - "http://identifiers.org/kegg.compound/C00008" - SUM_P part "http://identifiers.org/obo.chebi/CHEBI:15422", - "http://identifiers.org/obo.chebi/CHEBI:16761", - "http://identifiers.org/obo.chebi/CHEBI:16027" - SUM_P part "http://identifiers.org/kegg.compound/C00002", - "http://identifiers.org/kegg.compound/C00008", - "http://identifiers.org/kegg.compound/C00020", - "http://identifiers.org/chebi/CHEBI:15422" - AMP identity "http://identifiers.org/obo.chebi/CHEBI:16027", - "http://identifiers.org/kegg.compound/C00020" - F26BP identity "http://identifiers.org/obo.chebi/CHEBI:28602", - "http://identifiers.org/kegg.compound/C00665" - vGLK identity "http://identifiers.org/ec-code/2.7.1.2", - "http://identifiers.org/kegg.reaction/R00299" - vGLK homolog "http://identifiers.org/reactome/REACT_1318" - vPGI identity "http://identifiers.org/ec-code/5.3.1.9", - "http://identifiers.org/kegg.reaction/R00771" - vPGI homolog "http://identifiers.org/reactome/REACT_116" - vGLYCO hypernym "http://identifiers.org/obo.go/GO:0005978" - vGLYCO homolog "http://identifiers.org/reactome/REACT_1736" - vTreha hypernym "http://identifiers.org/obo.go/GO:0005992" - vPFK identity "http://identifiers.org/ec-code/2.7.1.11", - "http://identifiers.org/kegg.reaction/R00756" - vPFK homolog "http://identifiers.org/reactome/REACT_736" - vALD identity "http://identifiers.org/ec-code/4.1.2.13", - "http://identifiers.org/kegg.reaction/R01070" - vALD homolog "http://identifiers.org/reactome/REACT_1602" - vGAPDH identity "http://identifiers.org/ec-code/1.2.1.12", - "http://identifiers.org/kegg.reaction/R01061" - vGAPDH homolog "http://identifiers.org/reactome/REACT_1847" - vPGK identity "http://identifiers.org/ec-code/2.7.2.3", - "http://identifiers.org/kegg.reaction/R01512" - vPGK homolog "http://identifiers.org/reactome/REACT_1771" - vPGM identity "http://identifiers.org/ec-code/5.4.2.1", - "http://identifiers.org/kegg.reaction/R01518" - vPGM homolog "http://identifiers.org/reactome/REACT_576" - vENO identity "http://identifiers.org/ec-code/4.2.1.11", - "http://identifiers.org/kegg.reaction/R00658" - vENO homolog "http://identifiers.org/reactome/REACT_1400" - vPYK identity "http://identifiers.org/ec-code/2.7.1.40", - "http://identifiers.org/kegg.reaction/R00200" - vPYK homolog "http://identifiers.org/reactome/REACT_1911" - vPDC identity "http://identifiers.org/ec-code/4.1.1.1", - "http://identifiers.org/kegg.reaction/R00224" - vSUC hypernym "http://identifiers.org/obo.go/GO:0006105" - vGLT hypernym "http://identifiers.org/obo.go/GO:0046323" - vGLT homolog "http://identifiers.org/reactome/REACT_2092" - vADH homolog "http://identifiers.org/reactome/REACT_799" - vADH hypernym "http://identifiers.org/ec-code/1.1.1.2", - "http://identifiers.org/kegg.reaction/R00746" - vG3PDH hypernym "http://identifiers.org/ec-code/1.1.1.8" - vATP hypernym "http://identifiers.org/ec-code/3.6.1.3", - "http://identifiers.org/obo.go/GO:0016887" -end - -Teusink2000_Glycolysis is "Teusink2000_Glycolysis" - -Teusink2000_Glycolysis model_entity_is "http://identifiers.org/biomodels.db/MODEL6623915522" -Teusink2000_Glycolysis model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000064" -Teusink2000_Glycolysis description "http://identifiers.org/pubmed/10951190" -Teusink2000_Glycolysis taxon "http://identifiers.org/taxonomy/4932" -Teusink2000_Glycolysis identity "http://identifiers.org/kegg.pathway/sce00010", - "http://identifiers.org/obo.go/GO:0006096" -Teusink2000_Glycolysis homolog "http://identifiers.org/reactome/REACT_723" diff --git a/BioModelsRAG/data/BIOMD0000000065.txt b/BioModelsRAG/data/BIOMD0000000065.txt deleted file mode 100644 index 5ad7aba7124712dce476693bc25dab288d85d2ae..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000065.txt +++ /dev/null @@ -1,140 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Yildirim2003_Lac_operon() - - // Compartments and Species: - compartment cell; - species M in cell, B in cell, A in cell, L in cell, P in cell, I1 in cell; - species I2 in cell, I3 in cell, $L_e in cell; - - // Reactions: - r_m1: => M; cell*gamma_0; - r_m2: M => ; cell*M*(gamma_M + mu); - r_m3_i1: I1 => M; cell*I1/tau_M; - r_i1: => I1; cell*alpha_M*((K_1*exp(mu*tau_M*-2)*A^2 + 1)/(K + K_1*exp(-2*mu*tau_M)*A^2)); - r_b1: B => ; cell*B*(gamma_B + mu); - r_b2_i2: I2 => B; cell*I2/tau_B; - r_i2: => I2; cell*alpha_B*M*exp(-(mu*tau_B)); - r_a1: A => ; cell*A*(gamma_A + mu); - r_a2: A => ; cell*beta_A*B*(A/(K_A + A)); - r_a3_l1: L => A; cell*alpha_A*B*(L/(K_L + L)); - r_l2: L => ; cell*L*(gamma_L + mu); - r_l3: L => ; cell*beta_L1*P*(L/(K_L1 + L)); - r_l4: => L; cell*alpha_L*P*(L_e/(K_Le + L_e)); - r_p1: P => ; cell*P*(gamma_P + mu); - r_p2_i3: I3 => P; cell*I3/(tau_B + tau_P); - r_i3: => I3; cell*alpha_P*M*exp(-1*mu*(tau_B + tau_P)); - - // Species initializations: - M = 0.000626; - B = 0; - A = 0.038; - L = 0.372; - P = 0.0149; - I1 = 0; - I2 = 0; - I3 = 0; - L_e = 0.08; - - // Compartment initializations: - cell = 1; - - // Variable initializations: - mu = 0.0226; - gamma_M = 0.411; - gamma_B = 0.000833; - gamma_A = 0.52; - gamma_0 = 7.25e-07; - K = 7200; - alpha_M = 0.000997; - tau_B = 2; - alpha_A = 17600; - K_L1 = 1.81; - alpha_B = 0.0166; - K_A = 1.95; - beta_A = 21500; - tau_M = 0.1; - K_L = 0.97; - gamma_L = 0; - gamma_P = 0.65; - alpha_L = 2880; - alpha_P = 10; - tau_P = 0.83; - beta_L1 = 2650; - K_Le = 0.26; - K_1 = 25200; - - // Other declarations: - const cell, mu, gamma_M, gamma_B, gamma_A, gamma_0, K, alpha_M, tau_B, alpha_A; - const K_L1, alpha_B, K_A, beta_A, tau_M, K_L, gamma_L, gamma_P, alpha_L; - const alpha_P, tau_P, beta_L1, K_Le, K_1; - - // Unit definitions: - unit time_unit = 60 second; - unit substance = 1e-3 mole; - - // Display Names: - time_unit is "minute"; - substance is "millimoles"; - M is "mRNA"; - B is "Betagalactosidase"; - A is "allolactose"; - L is "lactose_internal"; - P is "permease"; - I1 is "PartialmRNA"; - I2 is "PartialBetagalactosidase"; - I3 is "PartialPermease"; - L_e is "External_Lactose"; - r_m1 is "Basal_mRNA_Synthesis"; - r_m2 is "mRNA_Degradation"; - r_m3_i1 is "allolactose_controlled_mRNA_synthesis"; - r_i1 is "allolactose_controlled_partial_mRNA_synthesis"; - r_b1 is "Beta_galactosidase_Degradation"; - r_b2_i2 is "Beta_galactosidase_synthesis"; - r_i2 is "Partial_Beta_galactosidase_synthesis"; - r_a1 is "Basal_Allolactose_Degradation"; - r_a2 is "Betagalactosidase_mediated_Allolactose_Degradation"; - r_a3_l1 is "Beta_galactosidase_reaction"; - r_l2 is "lactose_degradation"; - r_l3 is "Lactose_transport_out"; - r_l4 is "Lactose_transport_in"; - r_p1 is "permease_degradation"; - r_p2_i3 is "permease_synthesis"; - r_i3 is "partial_permease_synthesis"; - - // CV terms: - cell identity "http://identifiers.org/go/GO:0005623" - M identity "http://identifiers.org/chebi/CHEBI:33699" - B identity "http://identifiers.org/uniprot/P00722" - A part "http://identifiers.org/chebi/CHEBI:36229" - L identity "http://identifiers.org/chebi/CHEBI:17716", - "http://identifiers.org/kegg.compound/C00243" - P identity "http://identifiers.org/uniprot/P02920" - L_e identity "http://identifiers.org/chebi/CHEBI:17716", - "http://identifiers.org/kegg.compound/C00243" - r_m1 hypernym "http://identifiers.org/go/GO:0006351" - r_m2 identity "http://identifiers.org/go/GO:0006402" - r_m3_i1 hypernym "http://identifiers.org/go/GO:0009299" - r_i1 hypernym "http://identifiers.org/go/GO:0009299" - r_b1 hypernym "http://identifiers.org/go/GO:0044257" - r_b2_i2 hypernym "http://identifiers.org/go/GO:0006412" - r_i2 hypernym "http://identifiers.org/go/GO:0006412" - r_a1 hypernym "http://identifiers.org/go/GO:0046352" - r_a2 hypernym "http://identifiers.org/go/GO:0046352" - r_a3_l1 identity "http://identifiers.org/ec-code/3.2.1.108", - "http://identifiers.org/go/GO:0004565" - r_l2 identity "http://identifiers.org/go/GO:0005990" - r_l3 identity "http://identifiers.org/go/GO:0015155" - r_l4 identity "http://identifiers.org/go/GO:0015155" - r_p1 hypernym "http://identifiers.org/go/GO:0044257" - r_p2_i3 hypernym "http://identifiers.org/go/GO:0006412" - r_i3 hypernym "http://identifiers.org/go/GO:0006412" -end - -Yildirim2003_Lac_operon is "Yildirim2003_Lac_Operon" - -Yildirim2003_Lac_operon model_entity_is "http://identifiers.org/biomodels.db/MODEL6624248569" -Yildirim2003_Lac_operon model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000065" -Yildirim2003_Lac_operon description "http://identifiers.org/pubmed/12719218" -Yildirim2003_Lac_operon origin "http://identifiers.org/pubmed/9104037" -Yildirim2003_Lac_operon hypernym "http://identifiers.org/go/GO:0045990" -Yildirim2003_Lac_operon taxon "http://identifiers.org/taxonomy/562" diff --git a/BioModelsRAG/data/BIOMD0000000066.txt b/BioModelsRAG/data/BIOMD0000000066.txt deleted file mode 100644 index 6d69a7df2a6b0652f302891f1c898542cab990a4..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000066.txt +++ /dev/null @@ -1,217 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Chassagnole2001_Threonine_Synthesis() - - // Compartments and Species: - compartment compartment_; - species aspp in compartment_, asa in compartment_, hs in compartment_, hsp in compartment_; - species phos in compartment_, thr in compartment_, asp in compartment_; - species nadp in compartment_, nadph in compartment_, adp in compartment_; - species atp in compartment_; - - // Reactions: - vak: atp + asp -> aspp + adp; compartment_*(vak_vm11*(asp*atp - aspp*adp/vak_keqak)/((vak_k11*(1 + (thr/vak_k1thr)^vak_nak1)/(1 + (thr/(vak_alpha*vak_k1thr))^vak_nak1) + vak_k11*aspp/vak_k1aspp + asp)*(vak_k1atp*(1 + adp/vak_k1adp) + atp)) + vak_vm13*(asp*atp - aspp*adp/vak_keqak)/((1 + (vak_lys/vak_k1lys)^vak_nak3)*(vak_k13*(1 + aspp/vak_k13aspp) + asp)*(vak_k13atp*(1 + adp/vak_k13adp) + atp))); - vasd: nadph + aspp -> nadp + phos + asa; compartment_*(vasd_vm2f*(aspp*nadph - asa*nadp*phos/vasd_k2eq)/((vasd_k2aspp*(1 + asa/vasd_k2asa)*(1 + phos/vasd_k2p) + aspp)*(vasd_k2nadph*(1 + nadp/vasd_k2nadp) + nadph))); - vhdh: nadph + asa -> hs + nadp; compartment_*(vhdh_vm3f*(asa*nadph - hs*nadp/vhdh_k3eq)/(((1 + (thr/vhdh_k3thr)^vhdh_nhdh1)/(1 + (thr/(vhdh_alpha3*vhdh_k3thr))^vhdh_nhdh1))*(vhdh_k3asa + asa + hs*vhdh_k3asa/vhdh_k3hs)*(vhdh_k3nadph*(1 + nadp/vhdh_k3nadp) + nadph))); - vtsy: hsp -> thr + phos; compartment_*vtsy_vm5*hsp/(hsp + vtsy_k5hsp); - vhk: hs + atp -> hsp + adp; compartment_*(vhk_vm4f*hs*atp/((1 + vhk_lys/vhk_k4lys)*(atp + vhk_k4atp*(1 + hs/vhk_k4ihs))*(hs + vhk_k4hs*(1 + thr/vhk_k4thr)*(1 + atp/vhk_k4iatp)))); - vnadph_endo: nadph -> nadp; compartment_*vnadph_endo_prot*vnadph_endo_knadph*nadph; - vatpase: atp -> adp + phos; compartment_*vatpase_prot*vatpase_katpase; - - // Species initializations: - aspp = 0; - asa = 0; - hs = 0; - hsp = 0; - phos = 0; - thr = 2; - asp = 2; - nadp = 0; - nadph = 2; - adp = 0; - atp = 10; - - // Compartment initializations: - compartment_ = 1; - - // Variable initializations: - vak_vm11 = 0.15; - vak_vm11 has mM_per_min; - vak_keqak = 0.00064; - vak_keqak has dimensionless; - vak_k11 = 0.97; - vak_k11 has mM; - vak_k1thr = 0.167; - vak_k1thr has mM; - vak_nak1 = 4.09; - vak_nak1 has dimensionless; - vak_alpha = 2.47; - vak_alpha has dimensionless; - vak_k1aspp = 0.017; - vak_k1aspp has mM; - vak_k1atp = 0.98; - vak_k1atp has mM; - vak_k1adp = 0.25; - vak_k1adp has mM; - vak_vm13 = 0.0722; - vak_vm13 has mM_per_min; - vak_lys = 0.46; - vak_lys has mM; - vak_k1lys = 0.391; - vak_k1lys has mM; - vak_nak3 = 2.8; - vak_nak3 has dimensionless; - vak_k13 = 0.32; - vak_k13 has mM; - vak_k13aspp = 0.017; - vak_k13aspp has mM; - vak_k13atp = 0.22; - vak_k13atp has mM; - vak_k13adp = 0.25; - vak_k13adp has mM; - vasd_vm2f = 0.1812; - vasd_vm2f has mM_per_min; - vasd_k2eq = 56.4150334574039; - vasd_k2eq has dimensionless; - vasd_k2aspp = 0.022; - vasd_k2aspp has mM; - vasd_k2asa = 0.11; - vasd_k2asa has mM; - vasd_k2p = 10; - vasd_k2p has mM; - vasd_k2nadph = 0.029; - vasd_k2nadph has mM; - vasd_k2nadp = 0.144; - vasd_k2nadp has mM; - vhdh_vm3f = 1.001; - vhdh_vm3f has mM_per_min; - vhdh_k3eq = 3162.27766016838; - vhdh_k3eq has dimensionless; - vhdh_k3thr = 0.097; - vhdh_k3thr has mM; - vhdh_nhdh1 = 1.41; - vhdh_nhdh1 has dimensionless; - vhdh_alpha3 = 3.93; - vhdh_alpha3 has dimensionless; - vhdh_k3asa = 0.24; - vhdh_k3asa has mM; - vhdh_k3hs = 3.39; - vhdh_k3hs has mM; - vhdh_k3nadph = 0.037; - vhdh_k3nadph has mM; - vhdh_k3nadp = 0.067; - vhdh_k3nadp has mM; - vtsy_vm5 = 0.0434; - vtsy_vm5 has mM_per_min; - vtsy_k5hsp = 0.31; - vtsy_k5hsp has mM; - vhk_vm4f = 0.1; - vhk_vm4f has mM_per_min; - vhk_lys = 0.46; - vhk_lys has mM; - vhk_k4lys = 9.45; - vhk_k4lys has mM; - vhk_k4atp = 0.072; - vhk_k4atp has mM; - vhk_k4ihs = 4.7; - vhk_k4ihs has mM; - vhk_k4hs = 0.11; - vhk_k4hs has mM; - vhk_k4thr = 1.09; - vhk_k4thr has mM; - vhk_k4iatp = 4.35; - vhk_k4iatp has mM; - vnadph_endo_knadph = 5.4e-06; - vnadph_endo_knadph has litre_per_mg_per_min; - vnadph_endo_prot = 202; - vnadph_endo_prot has mg_per_litre; - vatpase_katpase = 4.1e-05; - vatpase_katpase has millimole_per_mg_per_min; - vatpase_prot = 202; - vatpase_prot has mg_per_litre; - - // Other declarations: - const compartment_; - - // Unit definitions: - unit substance = 1e-3 mole; - unit time_unit = 60 second; - unit mM = 1e-3 mole / litre; - unit mM_per_min = 1e-3 mole / (litre * 60 second); - unit litre_per_mg_per_min = litre / (1e-3 gram * 60 second); - unit millimole_per_mg_per_min = 1e-3 mole / (1e-3 gram * 60 second); - unit mg_per_litre = 1e-3 gram / litre; - - // Display Names: - substance is "millimole"; - time_unit is "min"; - aspp is "Aspartyl phosphate"; - asa is "Aspartate beta-semialdehyde"; - hs is "Homoserine"; - hsp is "O-Phospho-homoserine"; - phos is "Phos"; - thr is "Threonine"; - asp is "Aspartate"; - nadp is "NADP"; - nadph is "NADPH"; - adp is "ADP"; - atp is "ATP"; - vak is "Aspartate Kinase"; - vasd is "Aspartate semialdehyde dehydrogenase"; - vhdh is "Homoserine dehydrogenase"; - vtsy is "Threonine synthase"; - vhk is "Homoserine kinase"; - vnadph_endo is "Endogenous consumption of NADPH"; - vatpase is "ATPase"; - - // CV terms: - compartment_ identity "http://identifiers.org/obo.go/GO:0005623" - aspp identity "http://identifiers.org/obo.chebi/CHEBI:15836", - "http://identifiers.org/kegg.compound/C03082" - asa identity "http://identifiers.org/obo.chebi/CHEBI:18051", - "http://identifiers.org/kegg.compound/C00441" - hs identity "http://identifiers.org/obo.chebi/CHEBI:15699", - "http://identifiers.org/kegg.compound/C00263" - hsp identity "http://identifiers.org/obo.chebi/CHEBI:15961", - "http://identifiers.org/kegg.compound/C01102" - phos identity "http://identifiers.org/obo.chebi/CHEBI:18367", - "http://identifiers.org/kegg.compound/C00009" - thr identity "http://identifiers.org/obo.chebi/CHEBI:16857", - "http://identifiers.org/kegg.compound/C00188" - asp identity "http://identifiers.org/obo.chebi/CHEBI:17053", - "http://identifiers.org/kegg.compound/C00049" - nadp identity "http://identifiers.org/obo.chebi/CHEBI:18009", - "http://identifiers.org/kegg.compound/C00006" - nadph identity "http://identifiers.org/obo.chebi/CHEBI:16474", - "http://identifiers.org/kegg.compound/C00005" - adp identity "http://identifiers.org/obo.chebi/CHEBI:16761", - "http://identifiers.org/kegg.compound/C00008" - atp identity "http://identifiers.org/obo.chebi/CHEBI:15422", - "http://identifiers.org/kegg.compound/C00002" - vak identity "http://identifiers.org/kegg.reaction/R00480" - vak hypernym "http://identifiers.org/ec-code/2.7.2.4", - "http://identifiers.org/obo.go/GO:0004072" - vasd hypernym "http://identifiers.org/ec-code/1.2.1.11", - "http://identifiers.org/obo.go/GO:0004073" - vasd identity "http://identifiers.org/kegg.reaction/R02291" - vhdh hypernym "http://identifiers.org/ec-code/1.1.1.3", - "http://identifiers.org/obo.go/GO:0004412" - vhdh identity "http://identifiers.org/kegg.reaction/R01775" - vtsy identity "http://identifiers.org/kegg.reaction/R01466" - vtsy hypernym "http://identifiers.org/ec-code/4.2.3.1", - "http://identifiers.org/obo.go/GO:0004795" - vhk hypernym "http://identifiers.org/ec-code/2.7.1.39", - "http://identifiers.org/obo.go/GO:0004413" - vhk identity "http://identifiers.org/kegg.reaction/R01771" - vnadph_endo hypernym "http://identifiers.org/obo.go/GO:0006739" - vatpase identity "http://identifiers.org/obo.go/GO:0016887" -end - -Chassagnole2001_Threonine_Synthesis is "Chassagnole2001_Threonine Synthesis" - -Chassagnole2001_Threonine_Synthesis model_entity_is "http://identifiers.org/biomodels.db/MODEL6624131052" -Chassagnole2001_Threonine_Synthesis model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000066" -Chassagnole2001_Threonine_Synthesis description "http://identifiers.org/pubmed/11368770" -Chassagnole2001_Threonine_Synthesis part "http://identifiers.org/obo.go/GO:0009088", - "http://identifiers.org/obo.go/GO:0006531" -Chassagnole2001_Threonine_Synthesis taxon "http://identifiers.org/taxonomy/83333" -Chassagnole2001_Threonine_Synthesis hypernym "http://identifiers.org/kegg.pathway/map00260" diff --git a/BioModelsRAG/data/BIOMD0000000067.txt b/BioModelsRAG/data/BIOMD0000000067.txt deleted file mode 100644 index 36e49c7f7f3c68b7dacf067f610bb6e9861bf9e8..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000067.txt +++ /dev/null @@ -1,131 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Fung2005_Metabolator() - - // Compartments and Species: - compartment compartment_; - species AcCoA in compartment_, AcP in compartment_, OAc in compartment_; - species HOAc in compartment_, LacI in compartment_, Acs in compartment_; - species Pta in compartment_, $HOAc_E in compartment_; - - // Reactions: - V_gly: => AcCoA; compartment_*S0; - V_TCA: AcCoA => ; compartment_*kTCA*AcCoA; - V_out: HOAc -> $HOAc_E; compartment_*k3*(HOAc - HOAc_E); - V_Pta: AcCoA => AcP; compartment_*k1*Pta*AcCoA/(KM1 + AcCoA); - V_Ack: AcP -> OAc; compartment_*(kAck_f*AcP - kAck_r*OAc); - V_Acs: OAc => AcCoA; compartment_*k2*Acs*OAc/(KM2 + OAc); - V_Ace: OAc -> HOAc; compartment_*C*(OAc*H - Keq*HOAc); - R_LacI: => LacI; compartment_*(alpha1*(AcP/Kg1)^n/(1 + (AcP/Kg1)^n) + alpha0); - R_Acs: => Acs; compartment_*(alpha2*(AcP/Kg2)^n/(1 + (AcP/Kg2)^n) + alpha0); - R_Pta: => Pta; alpha3/(1 + (LacI/Kg3)^n) + alpha0; - R_dLacI: LacI => ; compartment_*kd*LacI; - R_dAcs: Acs => ; compartment_*kd*Acs; - R_dPta: Pta => ; compartment_*kd*Pta; - - // Species initializations: - AcCoA = 0; - AcP = 0; - OAc = 0; - HOAc = 0; - LacI = 0; - Acs = 0; - Pta = 0; - HOAc_E = 0; - - // Compartment initializations: - compartment_ = 1; - - // Variable initializations: - S0 = 0.5; - kTCA = 10; - k1 = 80; - KM1 = 0.06; - k2 = 0.8; - KM2 = 0.1; - kAck_f = 1; - kAck_r = 1; - C = 100; - H = 1e-07; - Keq = 0.0005; - k3 = 0.01; - alpha0 = 0; - alpha1 = 0.1; - alpha2 = 2; - alpha3 = 2; - Kg1 = 10; - Kg2 = 10; - Kg3 = 0.001; - n = 2; - kd = 0.06; - - // Other declarations: - const compartment_, S0, kTCA, k1, KM1, k2, KM2, kAck_f, kAck_r, C, H, Keq; - const k3, alpha0, alpha1, alpha2, alpha3, Kg1, Kg2, Kg3, n, kd; - - // Display Names: - compartment_ is "Intracellular"; - AcCoA is "Acetyl-CoA"; - AcP is "Acetyl phosphate"; - OAc is "Acetate"; - HOAc is "protonated acetate"; - LacI is "lac repressor"; - Acs is "Acetyl-CoA synthase"; - Pta is "Phosphate acetyl transferase"; - HOAc_E is "acetate export"; - V_gly is "Glycolytic flux"; - V_TCA is "Flux to TCA cycle"; - V_out is "Intercellular transport of Acetate"; - V_Pta is "Phosphate acetyl transferase flux"; - V_Ack is "Acetate kinase"; - V_Acs is "Acetyl-CoA synthase flux"; - V_Ace is "Acid-base equilibrium"; - R_LacI is "LacI synthesis"; - R_Acs is "Acetyl-CoA synthase synthesis"; - R_Pta is "Phosphate acetyl transferase synthase"; - R_dLacI is "LacI degradation"; - R_dAcs is "Acs degradation"; - R_dPta is "Pta degradation"; - - // CV terms: - compartment_ identity "http://identifiers.org/obo.go/GO:0005622" - AcCoA identity "http://identifiers.org/obo.chebi/CHEBI:15351", - "http://identifiers.org/kegg.compound/C00024" - AcP identity "http://identifiers.org/obo.chebi/CHEBI:15350", - "http://identifiers.org/kegg.compound/C00227" - OAc identity "http://identifiers.org/obo.chebi/CHEBI:30089", - "http://identifiers.org/kegg.compound/C00033" - HOAc hypernym "http://identifiers.org/obo.chebi/CHEBI:30089", - "http://identifiers.org/kegg.compound/C00033" - LacI parthood "http://identifiers.org/obo.go/GO:0017053" - Acs identity "http://identifiers.org/uniprot/P27550" - Pta identity "http://identifiers.org/uniprot/P0A9M8" - HOAc_E hypernym "http://identifiers.org/obo.chebi/CHEBI:30089", - "http://identifiers.org/kegg.compound/C00033" - V_gly version "http://identifiers.org/obo.go/GO:0006096" - V_TCA version "http://identifiers.org/obo.go/GO:0006099" - V_out hypernym "http://identifiers.org/obo.go/GO:0015123" - V_Pta identity "http://identifiers.org/ec-code/2.3.1.8", - "http://identifiers.org/kegg.reaction/R00230" - V_Ack hypernym "http://identifiers.org/ec-code/2.7.2.1", - "http://identifiers.org/obo.go/GO:0008776" - V_Acs hypernym "http://identifiers.org/ec-code/6.2.1.1", - "http://identifiers.org/obo.go/GO:0019427" - V_Acs identity "http://identifiers.org/kegg.reaction/R00235" - R_LacI part "http://identifiers.org/obo.go/GO:0006351", - "http://identifiers.org/obo.go/GO:0006412" - R_Acs part "http://identifiers.org/obo.go/GO:0006351", - "http://identifiers.org/obo.go/GO:0006412" - R_Pta part "http://identifiers.org/obo.go/GO:0006351", - "http://identifiers.org/obo.go/GO:0006412" - R_dLacI hypernym "http://identifiers.org/obo.go/GO:0030163" - R_dAcs hypernym "http://identifiers.org/obo.go/GO:0030163" - R_dPta hypernym "http://identifiers.org/obo.go/GO:0030163" -end - -Fung2005_Metabolator is "Fung2005_Metabolic_Oscillator" - -Fung2005_Metabolator model_entity_is "http://identifiers.org/biomodels.db/MODEL6624231052" -Fung2005_Metabolator model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000067" -Fung2005_Metabolator description "http://identifiers.org/pubmed/15875027" -Fung2005_Metabolator hypernym "http://identifiers.org/obo.go/GO:0045990" -Fung2005_Metabolator taxon "http://identifiers.org/taxonomy/83333" diff --git a/BioModelsRAG/data/BIOMD0000000068.txt b/BioModelsRAG/data/BIOMD0000000068.txt deleted file mode 100644 index dc450fed86b1bab6b61d25160232711440a42a26..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000068.txt +++ /dev/null @@ -1,104 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Curien2003_MetThr_synthesis() - - // Compartments and Species: - compartment compartment_; - species Phser in compartment_, $Thr in compartment_, $Cystathionine in compartment_; - species $Hser in compartment_, $Phi in compartment_, $Cys in compartment_; - species $AdoMet in compartment_, $CGS in compartment_, $TS in compartment_; - - // Reactions: - v1: $Hser -> Phser; compartment_*v1_V0; - vCys: Phser + $Cys -> $Cystathionine + $Phi; CGS*(vCys_kcat2/(1 + vCys_KmCYS/Cys))*Phser/(Phser + vCys_KmPHSER*(1 + Phi/vCys_Ki2)/(1 + vCys_KmCYS/Cys)); - vThr: Phser -> $Thr + $Phi; TS*(5.9e-4 + 0.062*AdoMet^2.9/(32^2.9 + AdoMet^2.9))*Phser/(1 + Phi/vThr_Ki3); - - // Species initializations: - Phser = 0; - Thr = 0; - Cystathionine = 0; - Hser = 0; - Phi = 10000; - Cys = 15; - AdoMet = 20; - CGS = 0.7; - TS = 5; - - // Compartment initializations: - compartment_ = 1; - - // Variable initializations: - v1_V0 = 1; - v1_V0 has microM_per_second; - vCys_kcat2 = 30; - vCys_kcat2 has microM; - vCys_KmCYS = 460; - vCys_KmCYS has microM; - vCys_KmPHSER = 2500; - vCys_KmPHSER has microM; - vCys_Ki2 = 2000; - vCys_Ki2 has microM; - vThr_Ki3 = 1000; - vThr_Ki3 has microM; - - // Other declarations: - const compartment_; - - // Unit definitions: - unit substance = 1e-6 mole; - unit microM = 1e-6 mole / litre; - unit sec_inverse = 1 / second; - unit microM_per_second = 1e-6 mole / (litre * second); - - // Display Names: - substance is "micromole"; - compartment_ is "Cell"; - Phser is "Phosphohomoserine"; - Thr is "Threonine"; - Hser is "Homoserine"; - Phi is "Inorganic phosphate"; - Cys is "Cysteine"; - AdoMet is "S-adenosylmethionine"; - CGS is "Cystathionine gamma-synthase"; - TS is "Threonine synthase"; - v1 is "Phosphohomoserine synthesis"; - vCys is "Cystathionine gamma-synthase"; - vThr is "Threonine Synthase"; - - // CV terms: - compartment_ identity "http://identifiers.org/obo.go/GO:0005623" - Phser identity "http://identifiers.org/obo.chebi/CHEBI:15961", - "http://identifiers.org/kegg.compound/C01102" - Thr identity "http://identifiers.org/obo.chebi/CHEBI:16857", - "http://identifiers.org/kegg.compound/C00188" - Cystathionine identity "http://identifiers.org/obo.chebi/CHEBI:17482", - "http://identifiers.org/kegg.compound/C02291" - Hser identity "http://identifiers.org/obo.chebi/CHEBI:15699", - "http://identifiers.org/kegg.compound/C00263" - Phi identity "http://identifiers.org/obo.chebi/CHEBI:18367", - "http://identifiers.org/kegg.compound/C00009" - Cys identity "http://identifiers.org/obo.chebi/CHEBI:17561", - "http://identifiers.org/kegg.compound/C00097" - AdoMet identity "http://identifiers.org/obo.chebi/CHEBI:15414", - "http://identifiers.org/kegg.compound/C00019" - CGS hypernym "http://identifiers.org/uniprot/P55217" - TS hypernym "http://identifiers.org/uniprot/Q9S7B5" - v1 hypernym "http://identifiers.org/ec-code/2.7.1.39", - "http://identifiers.org/obo.go/GO:0004413" - v1 identity "http://identifiers.org/kegg.reaction/R01775" - vCys hypernym "http://identifiers.org/ec-code/2.5.1.48", - "http://identifiers.org/obo.go/GO:0003962" - vThr identity "http://identifiers.org/kegg.reaction/R01466" - vThr hypernym "http://identifiers.org/ec-code/4.2.3.1", - "http://identifiers.org/obo.go/GO:0004795" -end - -Curien2003_MetThr_synthesis is "Curien2003_MetThr_synthesis" - -Curien2003_MetThr_synthesis model_entity_is "http://identifiers.org/biomodels.db/MODEL6624146302" -Curien2003_MetThr_synthesis model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000068" -Curien2003_MetThr_synthesis description "http://identifiers.org/pubmed/14622248" -Curien2003_MetThr_synthesis part "http://identifiers.org/obo.go/GO:0019283", - "http://identifiers.org/obo.go/GO:0009088" -Curien2003_MetThr_synthesis part "http://identifiers.org/kegg.pathway/map00260", - "http://identifiers.org/kegg.pathway/map00271" -Curien2003_MetThr_synthesis taxon "http://identifiers.org/taxonomy/3702" diff --git a/BioModelsRAG/data/BIOMD0000000069.txt b/BioModelsRAG/data/BIOMD0000000069.txt deleted file mode 100644 index bde99e43d205b32509545c8b02c7a5ecf69e977b..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000069.txt +++ /dev/null @@ -1,99 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Src_MitoticActivation() - - // Compartments and Species: - compartment default; - species srci in default, srco in default, srca in default, srcc in default; - species Cbp_P_CSK in default, CSK_cytoplasm in default, PTP in default; - species PTP_pY789 in default, Cbp in default, Cbp_P in default; - - // Assignment Rules: - ptp_activity := PTP_background + Kser*PTP_pY789; - src_activity := rho_srco*srco + rho_srca*srca + src_background + rho_srcc*srcc; - - // Reactions: - v1: srci -> srco; (k2*ptp_activity*srci - k1*Cbp_P_CSK*srco)*default; - v2: srco -> srca; (k3*src_activity*srco - p1*srca)*default; - v3: srca -> srcc; (k1*Cbp_P_CSK*srca - k2*ptp_activity*srcc)*default; - v4: srcc => srci; default*k4*p1*srcc; - CSK_translocation: CSK_cytoplasm + Cbp_P -> Cbp_P_CSK; (Cbp_P*kCSKon*CSK_cytoplasm - kCSKoff*Cbp_P_CSK)*default; - PTP_phosphorylation: PTP -> PTP_pY789; default*((kPTP*src_activity + p3)*PTP - p2*PTP_pY789); - Cbp_phosphorylation: Cbp => Cbp_P; kCbp*src_activity*Cbp*default; - - // Species initializations: - srci = 1; - srco = 0; - srca = 0; - srcc = 0; - Cbp_P_CSK = 0; - CSK_cytoplasm = 1; - PTP = 1; - PTP_pY789 = 0; - Cbp = 1; - Cbp_P = 0; - - // Compartment initializations: - default = 1; - - // Variable initializations: - k1 = 1; - k2 = 0.8; - k3 = 1; - k4 = 10; - kPTP = 1; - kCbp = 1; - p1 = 0.05; - p2 = 0.15; - p3 = 0.035; - src_background = 0.0001; - PTP_background = 0; - kCSKon = 0.1; - kCSKoff = 0.01; - rho_srca = 1; - rho_srco = 0; - rho_srcc = 1; - Kser = 1; - acsk0 = 0; - - // Other declarations: - var ptp_activity, src_activity; - const default, k1, k2, k3, k4, kPTP, kCbp, p1, p2, p3, src_background, PTP_background; - const kCSKon, kCSKoff, rho_srca, rho_srco, rho_srcc, Kser, acsk0; - - // CV terms: - default identity "http://identifiers.org/go/GO:0005623" - srci hypernym "http://identifiers.org/uniprot/P12931" - srco hypernym "http://identifiers.org/uniprot/P12931" - srca hypernym "http://identifiers.org/uniprot/P12931" - srcc hypernym "http://identifiers.org/uniprot/P12931" - Cbp_P_CSK part "http://identifiers.org/uniprot/P41240", - "http://identifiers.org/uniprot/Q9NWQ8" - CSK_cytoplasm identity "http://identifiers.org/uniprot/P41240" - PTP hypernym "http://identifiers.org/uniprot/P18433" - PTP_pY789 hypernym "http://identifiers.org/uniprot/P18433" - Cbp hypernym "http://identifiers.org/uniprot/Q9NWQ8" - Cbp_P hypernym "http://identifiers.org/uniprot/Q9NWQ8" - v1 hypernym "http://identifiers.org/ec-code/2.7.10.2", - "http://identifiers.org/go/GO:0004713" - v2 hypernym "http://identifiers.org/ec-code/2.7.10.2", - "http://identifiers.org/go/GO:0004713" - v3 hypernym "http://identifiers.org/ec-code/2.7.10.2", - "http://identifiers.org/go/GO:0004713" - v4 hypernym "http://identifiers.org/ec-code/3.1.3.48", - "http://identifiers.org/go/GO:0004725" - CSK_translocation part "http://identifiers.org/go/GO:0006461", - "http://identifiers.org/go/GO:0006612" - PTP_phosphorylation hypernym "http://identifiers.org/ec-code/2.7.10.2", - "http://identifiers.org/go/GO:0004713" - Cbp_phosphorylation hypernym "http://identifiers.org/ec-code/2.7.10.2", - "http://identifiers.org/go/GO:0004713" -end - -Src_MitoticActivation is "Fuss2006_MitoticActivation" - -Src_MitoticActivation model_entity_is "http://identifiers.org/biomodels.db/MODEL7146478294" -Src_MitoticActivation model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000069" -Src_MitoticActivation description "http://identifiers.org/pubmed/16873466" -Src_MitoticActivation taxon "http://identifiers.org/taxonomy/9606" -Src_MitoticActivation hypernym "http://identifiers.org/reactome/REACT_152", - "http://identifiers.org/go/GO:0000278" diff --git a/BioModelsRAG/data/BIOMD0000000070.txt b/BioModelsRAG/data/BIOMD0000000070.txt deleted file mode 100644 index 0a0c289cf10585b668f29ef12081f9d22737518a..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000070.txt +++ /dev/null @@ -1,754 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Holzhutter2004_Erythrocyte_Metabolism() - - // Compartments and Species: - compartment compartment_; - species Glcin in compartment_, MgATP in compartment_, Glc6P in compartment_; - species MgADP in compartment_, Fru6P in compartment_, Fru16P2 in compartment_; - species GraP in compartment_, DHAP in compartment_, Phi in compartment_; - species NAD in compartment_, Gri13P2 in compartment_, NADH in compartment_; - species Gri3P in compartment_, Gri23P2f in compartment_, Gri2P in compartment_; - species PEP in compartment_, Pyr in compartment_, Lac in compartment_, NADPHf in compartment_; - species NADPf in compartment_, AMPf in compartment_, ADPf in compartment_; - species GlcA6P in compartment_, Rul5P in compartment_, GSSG in compartment_; - species GSH in compartment_, Xul5P in compartment_, Rib5P in compartment_; - species Sed7P in compartment_, E4P in compartment_, MgAMP in compartment_; - species ATPf in compartment_, Mgf in compartment_, MgGri23P2 in compartment_; - species P1NADP in compartment_, P1f in compartment_, P1NADPH in compartment_; - species P2NADP in compartment_, P2f in compartment_, P2NADPH in compartment_; - species $PRPP in compartment_, $Lacex in compartment_, $Pyrex in compartment_; - species $Glcout in compartment_, $Phiex in compartment_; - - // Reactions: - vGLT: $Glcout -> Glcin; compartment_*((vGLT_Vmaxv0/vGLT_KMoutv0)*(Glcout - Glcin/vGLT_Keqv0)/(1 + Glcout/vGLT_KMoutv0 + Glcin/vGLT_KMinv0 + vGLT_alfav0*Glcout*Glcin/vGLT_KMoutv0/vGLT_KMinv0)); - vHEX: Glcin + MgATP -> Glc6P + MgADP; compartment_*((vHEX_Inhibv1*Glcin/(Glcin + vHEX_KMGlcv1))*(vHEX_Vmax1v1/vHEX_KMgATPv1)*(MgATP + (vHEX_Vmax2v1/vHEX_Vmax1v1)*MgATP*Mgf/vHEX_KMgATPMgv1 - Glc6P*MgADP/vHEX_Keqv1)/(1 + (MgATP/vHEX_KMgATPv1)*(1 + Mgf/vHEX_KMgATPMgv1) + Mgf/vHEX_KMgv1 + (1.55 + Glc6P/vHEX_KGlc6Pv1)*(1 + Mgf/vHEX_KMgv1) + (Gri23P2f + MgGri23P2)/vHEX_K23P2Gv1 + Mgf*(Gri23P2f + MgGri23P2)/(vHEX_KMgv1*vHEX_KMg23P2Gv1))); - vGPI: Glc6P -> Fru6P; compartment_*(vGPI_Vmaxv2*(Glc6P - Fru6P/vGPI_Keqv2)/(Glc6P + vGPI_KGlc6Pv2*(1 + Fru6P/vGPI_KFru6Pv2))); - vPFK: MgATP + Fru6P -> Fru16P2 + MgADP; compartment_*(vPFK_Vmaxv3*(Fru6P*MgATP - Fru16P2*MgADP/vPFK_Keqv3)/((Fru6P + vPFK_KFru6Pv3)*(MgATP + vPFK_KMgATPv3)*(1 + vPFK_L0v3*((1 + ATPf/vPFK_KATPv3)*(1 + Mgf/vPFK_KMgv3)/((1 + (AMPf + MgAMP)/vPFK_KAMPv3)*(1 + Fru6P/vPFK_KFru6Pv3)))^4))); - vALD: Fru16P2 -> GraP + DHAP; compartment_*((vALD_Vmaxv4/vALD_KFru16P2v4)*(Fru16P2 - GraP*DHAP/vALD_Keqv4)/(1 + Fru16P2/vALD_KFru16P2v4 + GraP/vALD_KiGraPv4 + DHAP*(GraP + vALD_KGraPv4)/(vALD_KDHAPv4*vALD_KiGraPv4) + Fru16P2*GraP/(vALD_KFru16P2v4*vALD_KiiGraPv4))); - vTPI: DHAP -> GraP; compartment_*(vTPI_Vmaxv5*(DHAP - GraP/vTPI_Keqv5)/(DHAP + vTPI_KDHAPv5*(1 + GraP/vTPI_KGraPv5))); - vGAPDH: GraP + Phi + NAD -> NADH + Gri13P2; compartment_*((vGAPDH_Vmaxv6/(vGAPDH_KNADv6*vGAPDH_KGraPv6*vGAPDH_KPv6))*(NAD*GraP*Phi - Gri13P2*NADH/vGAPDH_Keqv6)/((1 + NAD/vGAPDH_KNADv6)*(1 + GraP/vGAPDH_KGraPv6)*(1 + Phi/vGAPDH_KPv6) + (1 + NADH/vGAPDH_KNADHv6)*(1 + Gri13P2/vGAPDH_K13P2Gv6) - 1)); - vPGK: MgADP + Gri13P2 -> MgATP + Gri3P; compartment_*((vPGK_Vmaxv7/(vPGK_KMgADPv7*vPGK_K13P2Gv7))*(MgADP*Gri13P2 - MgATP*Gri3P/vPGK_Keqv7)/((1 + MgADP/vPGK_KMgADPv7)*(1 + Gri13P2/vPGK_K13P2Gv7) + (1 + MgATP/vPGK_KMgATPv7)*(1 + Gri3P/vPGK_K3PGv7) - 1)); - vBPGM: Gri13P2 -> Gri23P2f; compartment_*(vBPGM_kDPGMv8*(Gri13P2 - (Gri23P2f + MgGri23P2)/vBPGM_Keqv8)/(1 + (Gri23P2f + MgGri23P2)/vBPGM_K23P2Gv8)); - vBPGP: Gri23P2f -> Gri3P + Phi; compartment_*(vBPGP_Vmaxv9*(Gri23P2f + MgGri23P2 - Gri3P/vBPGP_Keqv9)/(Gri23P2f + MgGri23P2 + vBPGP_K23P2Gv9)); - vPGM: Gri3P -> Gri2P; compartment_*(vPGM_Vmaxv10*(Gri3P - Gri2P/vPGM_Keqv10)/(Gri3P + vPGM_K3PGv10*(1 + Gri2P/vPGM_K2PGv10))); - vENO: Gri2P -> PEP; compartment_*(vENO_Vmaxv11*(Gri2P - PEP/vENO_Keqv11)/(Gri2P + vENO_K2PGv11*(1 + PEP/vENO_KPEPv11))); - vPK: PEP + MgADP -> MgATP + Pyr; compartment_*(vPK_Vmaxv12*(PEP*MgADP - Pyr*MgATP/vPK_Keqv12)/((PEP + vPK_KPEPv12)*(MgADP + vPK_KMgADPv12)*(1 + vPK_L0v12*(1 + (ATPf + MgATP)/vPK_KATPv12)^4/((1 + PEP/vPK_KPEPv12)^4*(1 + Fru16P2/vPK_KFru16P2v12)^4)))); - vLDHNADH: NADH + Pyr -> Lac + NAD; compartment_*vLDHNADH_Vmaxv13*(Pyr*NADH - Lac*NAD/vLDHNADH_Keqv13); - vLDHNADPH: Pyr + NADPHf -> Lac + NADPf; compartment_*vLDHNADPH_kLDHv14*(Pyr*NADPHf - Lac*NADPf/vLDHNADPH_Keqv14); - vATPase: MgATP -> Phi + MgADP; compartment_*vATPase_kATPasev15*MgATP; - vAK: MgATP + AMPf -> ADPf + MgADP; compartment_*((vAK_Vmaxv16/(vAK_KATPv16*vAK_KAMPv16))*(MgATP*AMPf - MgADP*ADPf/vAK_Keqv16)/((1 + MgATP/vAK_KATPv16)*(1 + AMPf/vAK_KAMPv16) + (MgADP + ADPf)/vAK_KADPv16 + MgADP*ADPf/vAK_KADPv16^2)); - vG6PDH: Glc6P + NADPf -> GlcA6P + NADPHf; compartment_*((vG6PDH_Vmaxv17/vG6PDH_KG6Pv17/vG6PDH_KNADPv17)*(Glc6P*NADPf - GlcA6P*NADPHf/vG6PDH_Keqv17)/(1 + NADPf*(1 + Glc6P/vG6PDH_KG6Pv17)/vG6PDH_KNADPv17 + (ATPf + MgATP)/vG6PDH_KATPv17 + NADPHf/vG6PDH_KNADPHv17 + (Gri23P2f + MgGri23P2)/vG6PDH_KPGA23v17)); - vPGLDH: GlcA6P + NADPf -> Rul5P + NADPHf; compartment_*((vPGLDH_Vmaxv18/vPGLDH_K6PG1v18/vPGLDH_KNADPv18)*(GlcA6P*NADPf - Rul5P*NADPHf/vPGLDH_Keqv18)/((1 + NADPf/vPGLDH_KNADPv18)*(1 + GlcA6P/vPGLDH_K6PG1v18 + (Gri23P2f + MgGri23P2)/vPGLDH_KPGA23v18) + (ATPf + MgATP)/vPGLDH_KATPv18 + NADPHf*(1 + GlcA6P/vPGLDH_K6PG2v18)/vPGLDH_KNADPHv18)); - vGSSGRD: GSSG + NADPHf -> 2 GSH + NADPf; compartment_*(vGSSGRD_Vmaxv19*(GSSG*NADPHf/(vGSSGRD_KGSSGv19*vGSSGRD_KNADPHv19) - (GSH^2/vGSSGRD_KGSHv19^2)*NADPf/(vGSSGRD_KNADPv19*vGSSGRD_Keqv19))/(1 + NADPHf*(1 + GSSG/vGSSGRD_KGSSGv19)/vGSSGRD_KNADPHv19 + (NADPf/vGSSGRD_KNADPv19)*(1 + GSH*(1 + GSH/vGSSGRD_KGSHv19)/vGSSGRD_KGSHv19))); - vGSHox: 2 GSH -> GSSG; compartment_*vGSHox_Kv20*GSH; - vRibPepi: Rul5P -> Xul5P; compartment_*(vRibPepi_Vmaxv21*(Rul5P - Xul5P/vRibPepi_Keqv21)/(Rul5P + vRibPepi_KRu5Pv21*(1 + Xul5P/vRibPepi_KX5Pv21))); - vRibPiso: Rul5P -> Rib5P; compartment_*(vRibPiso_Vmaxv22*(Rul5P - Rib5P/vRibPiso_Keqv22)/(Rul5P + vRibPiso_KRu5Pv22*(1 + Rib5P/vRibPiso_KR5Pv22))); - vTrKet1: Xul5P + Rib5P -> GraP + Sed7P; compartment_*(vTrKet1_Vmaxv23*(Rib5P*Xul5P - GraP*Sed7P/vTrKet1_Keqv23)/((vTrKet1_K1v23 + Rib5P)*Xul5P + (vTrKet1_K2v23 + vTrKet1_K6v23*Sed7P)*Rib5P + (vTrKet1_K3v23 + vTrKet1_K5v23*Sed7P)*GraP + vTrKet1_K4v23*Sed7P + vTrKet1_K7v23*Xul5P*GraP)); - vTrAld: GraP + Sed7P -> E4P + Fru6P; compartment_*(vTrAld_Vmaxv24*(Sed7P*GraP - E4P*Fru6P/vTrAld_Keqv24)/((vTrAld_K1v24 + GraP)*Sed7P + (vTrAld_K2v24 + vTrAld_K6v24*Fru6P)*GraP + (vTrAld_K3v24 + vTrAld_K5v24*Fru6P)*E4P + vTrAld_K4v24*Fru6P + vTrAld_K7v24*Sed7P*E4P)); - vPPRPPS: MgATP + Rib5P -> MgAMP + $PRPP; compartment_*(vPPRPPS_Vmaxv25*(Rib5P*MgATP - PRPP*MgAMP/vPPRPPS_Keqv25)/((vPPRPPS_KATPv25 + MgATP)*(vPPRPPS_KR5Pv25 + Rib5P))); - vTrKet2: Xul5P + E4P -> GraP + Fru6P; compartment_*(vTrKet2_Vmaxv26*(E4P*Xul5P - GraP*Fru6P/vTrKet2_Keqv26)/((vTrKet2_K1v26 + E4P)*Xul5P + (vTrKet2_K2v26 + vTrKet2_K6v26*Fru6P)*E4P + (vTrKet2_K3v26 + vTrKet2_K5v26*Fru6P)*GraP + vTrKet2_K4v26*Fru6P + vTrKet2_K7v26*Xul5P*GraP)); - vPhiexch: $Phiex -> Phi; compartment_*vPhiexch_Vmaxv27*(Phiex - Phi/vPhiexch_Keqv27); - vLacexch: $Lacex -> Lac; compartment_*vLacexch_Vmaxv28*(Lacex - Lac/vLacexch_Keqv28); - vPyrexch: $Pyrex -> Pyr; compartment_*vPyrexch_Vmaxv29*(Pyrex - Pyr/vPyrexch_Keqv29); - vMgATP: MgATP -> Mgf + ATPf; compartment_*vMgATP_EqMult*(MgATP - Mgf*ATPf/vMgATP_KdATP); - vMgADP: MgADP -> Mgf + ADPf; compartment_*vMgADP_EqMult*(MgADP - Mgf*ADPf/vMgADP_KdADP); - vMgAMP: MgAMP -> Mgf + AMPf; compartment_*vMgAMP_EqMult*(MgAMP - Mgf*AMPf/vMgAMP_KdAMP); - vMgGri23P2: MgGri23P2 -> Mgf + Gri23P2f; compartment_*vMgGri23P2_EqMult*(MgGri23P2 - Mgf*Gri23P2f/vMgGri23P2_Kd23P2G); - vP1NADP: P1NADP -> P1f + NADPf; compartment_*vP1NADP_EqMult*(P1NADP - P1f*NADPf/vP1NADP_Kd1); - vP1NADPH: P1NADPH -> P1f + NADPHf; compartment_*vP1NADPH_EqMult*(P1NADPH - P1f*NADPHf/vP1NADPH_Kd3); - vP2NADP: P2NADP -> P2f + NADPf; compartment_*vP2NADP_EqMult*(P2NADP - P2f*NADPf/vP2NADP_Kd2); - vP2NADPH: P2NADPH -> P2f + NADPHf; compartment_*vP2NADPH_EqMult*(P2NADPH - P2f*NADPHf/vP2NADPH_Kd4); - - // Species initializations: - Glcin = 4.5663; - MgATP = 1.4; - Glc6P = 0.0394; - MgADP = 0.1; - Fru6P = 0.0153; - Fru16P2 = 0.0097; - GraP = 0.0061; - DHAP = 0.1492; - Phi = 0.9992; - NAD = 0.0653; - Gri13P2 = 0.0005; - NADH = 0.0002; - Gri3P = 0.0658; - Gri23P2f = 2.0601; - Gri2P = 0.0084; - PEP = 0.0109; - Pyr = 0.084; - Lac = 1.6803; - NADPHf = 0.004; - NADPf = 0; - AMPf = 0; - ADPf = 0.25; - GlcA6P = 0.025; - Rul5P = 0.0047; - GSSG = 0.0004; - GSH = 3.1136; - Xul5P = 0.0127; - Rib5P = 0.014; - Sed7P = 0.0154; - E4P = 0.0063; - MgAMP = 0; - ATPf = 0.25; - Mgf = 0.8; - MgGri23P2 = 0.5; - P1NADP = 0; - P1f = 0; - P1NADPH = 0.024; - P2NADP = 0; - P2f = 0; - P2NADPH = 0.024; - PRPP = 1; - Lacex = 1.68; - Pyrex = 0.084; - Glcout = 5; - Phiex = 1; - - // Compartment initializations: - compartment_ = 1; - - // Variable initializations: - vGLT_Vmaxv0 = 33.6; - vGLT_Vmaxv0 has mM_per_hour; - vGLT_KMoutv0 = 1.7; - vGLT_KMoutv0 has mM; - vGLT_Keqv0 = 1; - vGLT_Keqv0 has dimensionless; - vGLT_KMinv0 = 6.9; - vGLT_KMinv0 has mM; - vGLT_alfav0 = 0.54; - vGLT_alfav0 has dimensionless; - vHEX_Inhibv1 = 1; - vHEX_Inhibv1 has dimensionless; - vHEX_KMGlcv1 = 0.1; - vHEX_KMGlcv1 has mM; - vHEX_Vmax1v1 = 15.8; - vHEX_Vmax1v1 has mM_per_hour; - vHEX_KMgATPv1 = 1.44; - vHEX_KMgATPv1 has mM; - vHEX_Vmax2v1 = 33.2; - vHEX_Vmax2v1 has mM_per_hour; - vHEX_KMgATPMgv1 = 1.14; - vHEX_KMgATPMgv1 has mM; - vHEX_Keqv1 = 3900; - vHEX_Keqv1 has mM; - vHEX_KMgv1 = 1.03; - vHEX_KMgv1 has mM; - vHEX_KGlc6Pv1 = 0.0045; - vHEX_KGlc6Pv1 has mM; - vHEX_K23P2Gv1 = 2.7; - vHEX_K23P2Gv1 has mM; - vHEX_KMg23P2Gv1 = 3.44; - vHEX_KMg23P2Gv1 has mM; - vGPI_Vmaxv2 = 935; - vGPI_Vmaxv2 has mM_per_hour; - vGPI_Keqv2 = 0.3925; - vGPI_Keqv2 has dimensionless; - vGPI_KGlc6Pv2 = 0.182; - vGPI_KGlc6Pv2 has mM; - vGPI_KFru6Pv2 = 0.071; - vGPI_KFru6Pv2 has mM; - vPFK_Vmaxv3 = 239; - vPFK_Vmaxv3 has mM_per_hour; - vPFK_Keqv3 = 100000; - vPFK_Keqv3 has dimensionless; - vPFK_KFru6Pv3 = 0.1; - vPFK_KFru6Pv3 has mM; - vPFK_KMgATPv3 = 0.068; - vPFK_KMgATPv3 has mM; - vPFK_L0v3 = 0.001072; - vPFK_L0v3 has dimensionless; - vPFK_KATPv3 = 0.01; - vPFK_KATPv3 has mM; - vPFK_KMgv3 = 0.44; - vPFK_KMgv3 has mM; - vPFK_KAMPv3 = 0.033; - vPFK_KAMPv3 has mM; - vALD_Vmaxv4 = 98.91000366; - vALD_Vmaxv4 has mM_per_hour; - vALD_KFru16P2v4 = 0.0071; - vALD_KFru16P2v4 has mM; - vALD_Keqv4 = 0.114; - vALD_Keqv4 has mM; - vALD_KiGraPv4 = 0.0572; - vALD_KiGraPv4 has mM; - vALD_KGraPv4 = 0.1906; - vALD_KGraPv4 has mM; - vALD_KDHAPv4 = 0.0364; - vALD_KDHAPv4 has mM; - vALD_KiiGraPv4 = 0.176; - vALD_KiiGraPv4 has mM; - vTPI_Vmaxv5 = 5456.600098; - vTPI_Vmaxv5 has mM_per_hour; - vTPI_Keqv5 = 0.0407; - vTPI_Keqv5 has dimensionless; - vTPI_KDHAPv5 = 0.838; - vTPI_KDHAPv5 has mM; - vTPI_KGraPv5 = 0.428; - vTPI_KGraPv5 has mM; - vGAPDH_Vmaxv6 = 4300; - vGAPDH_Vmaxv6 has mM_per_hour; - vGAPDH_KNADv6 = 0.05; - vGAPDH_KNADv6 has mM; - vGAPDH_KGraPv6 = 0.005; - vGAPDH_KGraPv6 has mM; - vGAPDH_KPv6 = 3.9; - vGAPDH_KPv6 has mM; - vGAPDH_Keqv6 = 0.000192; - vGAPDH_Keqv6 has dimensionless; - vGAPDH_KNADHv6 = 0.0083; - vGAPDH_KNADHv6 has mM; - vGAPDH_K13P2Gv6 = 0.0035; - vGAPDH_K13P2Gv6 has mM; - vPGK_Vmaxv7 = 5000; - vPGK_Vmaxv7 has mM_per_hour; - vPGK_KMgADPv7 = 0.35; - vPGK_KMgADPv7 has mM; - vPGK_K13P2Gv7 = 0.002; - vPGK_K13P2Gv7 has mM; - vPGK_Keqv7 = 1455; - vPGK_Keqv7 has dimensionless; - vPGK_KMgATPv7 = 0.48; - vPGK_KMgATPv7 has mM; - vPGK_K3PGv7 = 1.2; - vPGK_K3PGv7 has mM; - vBPGM_kDPGMv8 = 76000; - vBPGM_kDPGMv8 has hour_inverse; - vBPGM_Keqv8 = 100000; - vBPGM_Keqv8 has dimensionless; - vBPGM_K23P2Gv8 = 0.04; - vBPGM_K23P2Gv8 has mM; - vBPGP_Vmaxv9 = 0.53; - vBPGP_Vmaxv9 has mM_per_hour; - vBPGP_Keqv9 = 100000; - vBPGP_Keqv9 has dimensionless; - vBPGP_K23P2Gv9 = 0.2; - vBPGP_K23P2Gv9 has mM; - vPGM_Vmaxv10 = 2000; - vPGM_Vmaxv10 has mM_per_hour; - vPGM_Keqv10 = 0.145; - vPGM_Keqv10 has dimensionless; - vPGM_K3PGv10 = 5; - vPGM_K3PGv10 has mM; - vPGM_K2PGv10 = 1; - vPGM_K2PGv10 has mM; - vENO_Vmaxv11 = 1500; - vENO_Vmaxv11 has mM_per_hour; - vENO_Keqv11 = 1.7; - vENO_Keqv11 has dimensionless; - vENO_K2PGv11 = 1; - vENO_K2PGv11 has mM; - vENO_KPEPv11 = 1; - vENO_KPEPv11 has mM; - vPK_Vmaxv12 = 570; - vPK_Vmaxv12 has mM_per_hour; - vPK_Keqv12 = 13790; - vPK_Keqv12 has dimensionless; - vPK_KPEPv12 = 0.225; - vPK_KPEPv12 has mM; - vPK_KMgADPv12 = 0.474; - vPK_KMgADPv12 has mM; - vPK_L0v12 = 19; - vPK_L0v12 has dimensionless; - vPK_KATPv12 = 3.39; - vPK_KATPv12 has mM; - vPK_KFru16P2v12 = 0.005; - vPK_KFru16P2v12 has mM; - vLDHNADH_Vmaxv13 = 2800000; - vLDHNADH_Vmaxv13 has per_mM_hour; - vLDHNADH_Keqv13 = 9090; - vLDHNADH_Keqv13 has dimensionless; - vLDHNADPH_kLDHv14 = 243.4; - vLDHNADPH_kLDHv14 has per_mM_hour; - vLDHNADPH_Keqv14 = 14181.8; - vLDHNADPH_Keqv14 has dimensionless; - vATPase_kATPasev15 = 1.68; - vATPase_kATPasev15 has hour_inverse; - vAK_Vmaxv16 = 1380; - vAK_Vmaxv16 has mM_per_hour; - vAK_KATPv16 = 0.09; - vAK_KATPv16 has mM; - vAK_KAMPv16 = 0.08; - vAK_KAMPv16 has mM; - vAK_Keqv16 = 0.25; - vAK_Keqv16 has dimensionless; - vAK_KADPv16 = 0.11; - vAK_KADPv16 has mM; - vG6PDH_Vmaxv17 = 162; - vG6PDH_Vmaxv17 has mM_per_hour; - vG6PDH_KG6Pv17 = 0.0667; - vG6PDH_KG6Pv17 has mM; - vG6PDH_KNADPv17 = 0.00367; - vG6PDH_KNADPv17 has mM; - vG6PDH_Keqv17 = 2000; - vG6PDH_Keqv17 has dimensionless; - vG6PDH_KATPv17 = 0.749; - vG6PDH_KATPv17 has mM; - vG6PDH_KNADPHv17 = 0.00312; - vG6PDH_KNADPHv17 has mM; - vG6PDH_KPGA23v17 = 2.289; - vG6PDH_KPGA23v17 has mM; - vPGLDH_Vmaxv18 = 1575; - vPGLDH_Vmaxv18 has mM_per_hour; - vPGLDH_K6PG1v18 = 0.01; - vPGLDH_K6PG1v18 has mM; - vPGLDH_KNADPv18 = 0.018; - vPGLDH_KNADPv18 has mM; - vPGLDH_Keqv18 = 141.7; - vPGLDH_Keqv18 has dimensionless; - vPGLDH_KPGA23v18 = 0.12; - vPGLDH_KPGA23v18 has mM; - vPGLDH_KATPv18 = 0.154; - vPGLDH_KATPv18 has mM; - vPGLDH_K6PG2v18 = 0.058; - vPGLDH_K6PG2v18 has mM; - vPGLDH_KNADPHv18 = 0.0045; - vPGLDH_KNADPHv18 has mM; - vGSSGRD_Vmaxv19 = 90; - vGSSGRD_Vmaxv19 has mM_per_hour; - vGSSGRD_KGSSGv19 = 0.0652; - vGSSGRD_KGSSGv19 has mM; - vGSSGRD_KNADPHv19 = 0.00852; - vGSSGRD_KNADPHv19 has mM; - vGSSGRD_KGSHv19 = 20; - vGSSGRD_KGSHv19 has mM; - vGSSGRD_KNADPv19 = 0.07; - vGSSGRD_KNADPv19 has mM; - vGSSGRD_Keqv19 = 1.04; - vGSSGRD_Keqv19 has dimensionless; - vGSHox_Kv20 = 0.03; - vGSHox_Kv20 has hour_inverse; - vRibPepi_Vmaxv21 = 4634; - vRibPepi_Vmaxv21 has mM_per_hour; - vRibPepi_Keqv21 = 2.7; - vRibPepi_Keqv21 has dimensionless; - vRibPepi_KRu5Pv21 = 0.19; - vRibPepi_KRu5Pv21 has mM; - vRibPepi_KX5Pv21 = 0.5; - vRibPepi_KX5Pv21 has mM; - vRibPiso_Vmaxv22 = 730; - vRibPiso_Vmaxv22 has mM_per_hour; - vRibPiso_Keqv22 = 3; - vRibPiso_Keqv22 has dimensionless; - vRibPiso_KRu5Pv22 = 0.78; - vRibPiso_KRu5Pv22 has mM; - vRibPiso_KR5Pv22 = 2.2; - vRibPiso_KR5Pv22 has mM; - vTrKet1_Vmaxv23 = 23.5; - vTrKet1_Vmaxv23 has mM_per_hour; - vTrKet1_Keqv23 = 1.05; - vTrKet1_Keqv23 has dimensionless; - vTrKet1_K1v23 = 0.4177; - vTrKet1_K1v23 has mM; - vTrKet1_K2v23 = 0.3055; - vTrKet1_K2v23 has mM; - vTrKet1_K6v23 = 0.00774; - vTrKet1_K6v23 has dimensionless; - vTrKet1_K3v23 = 12.432; - vTrKet1_K3v23 has mM; - vTrKet1_K5v23 = 0.41139; - vTrKet1_K5v23 has dimensionless; - vTrKet1_K4v23 = 0.00496; - vTrKet1_K4v23 has mM; - vTrKet1_K7v23 = 48.8; - vTrKet1_K7v23 has dimensionless; - vTrAld_Vmaxv24 = 27.2; - vTrAld_Vmaxv24 has mM_per_hour; - vTrAld_Keqv24 = 1.05; - vTrAld_Keqv24 has dimensionless; - vTrAld_K1v24 = 0.00823; - vTrAld_K1v24 has mM; - vTrAld_K2v24 = 0.04765; - vTrAld_K2v24 has mM; - vTrAld_K6v24 = 0.4653; - vTrAld_K6v24 has dimensionless; - vTrAld_K3v24 = 0.1733; - vTrAld_K3v24 has mM; - vTrAld_K5v24 = 0.8683; - vTrAld_K5v24 has dimensionless; - vTrAld_K4v24 = 0.006095; - vTrAld_K4v24 has mM; - vTrAld_K7v24 = 2.524; - vTrAld_K7v24 has dimensionless; - vPPRPPS_Vmaxv25 = 1.1; - vPPRPPS_Vmaxv25 has mM_per_hour; - vPPRPPS_Keqv25 = 100000; - vPPRPPS_Keqv25 has dimensionless; - vPPRPPS_KATPv25 = 0.03; - vPPRPPS_KATPv25 has mM; - vPPRPPS_KR5Pv25 = 0.57; - vPPRPPS_KR5Pv25 has mM; - vTrKet2_Vmaxv26 = 23.5; - vTrKet2_Vmaxv26 has mM_per_hour; - vTrKet2_Keqv26 = 1.2; - vTrKet2_Keqv26 has dimensionless; - vTrKet2_K1v26 = 0.00184; - vTrKet2_K1v26 has mM; - vTrKet2_K2v26 = 0.3055; - vTrKet2_K2v26 has mM; - vTrKet2_K6v26 = 0.122; - vTrKet2_K6v26 has dimensionless; - vTrKet2_K3v26 = 0.0548; - vTrKet2_K3v26 has mM; - vTrKet2_K5v26 = 0.0287; - vTrKet2_K5v26 has dimensionless; - vTrKet2_K4v26 = 0.0003; - vTrKet2_K4v26 has mM; - vTrKet2_K7v26 = 0.215; - vTrKet2_K7v26 has dimensionless; - vPhiexch_Vmaxv27 = 100; - vPhiexch_Vmaxv27 has hour_inverse; - vPhiexch_Keqv27 = 1; - vPhiexch_Keqv27 has dimensionless; - vLacexch_Vmaxv28 = 10000; - vLacexch_Vmaxv28 has hour_inverse; - vLacexch_Keqv28 = 1; - vLacexch_Keqv28 has dimensionless; - vPyrexch_Vmaxv29 = 10000; - vPyrexch_Vmaxv29 has hour_inverse; - vPyrexch_Keqv29 = 1; - vPyrexch_Keqv29 has dimensionless; - vMgATP_EqMult = 10000000; - vMgATP_EqMult has hour_inverse; - vMgATP_KdATP = 0.072; - vMgATP_KdATP has mM; - vMgADP_EqMult = 10000000; - vMgADP_EqMult has hour_inverse; - vMgADP_KdADP = 0.76; - vMgADP_KdADP has mM; - vMgAMP_EqMult = 10000000; - vMgAMP_EqMult has hour_inverse; - vMgAMP_KdAMP = 16.64; - vMgAMP_KdAMP has mM; - vMgGri23P2_EqMult = 10000000; - vMgGri23P2_EqMult has hour_inverse; - vMgGri23P2_Kd23P2G = 1.667; - vMgGri23P2_Kd23P2G has mM; - vP1NADP_EqMult = 10000000; - vP1NADP_EqMult has hour_inverse; - vP1NADP_Kd1 = 0.0002; - vP1NADP_Kd1 has mM; - vP1NADPH_EqMult = 10000000; - vP1NADPH_EqMult has hour_inverse; - vP1NADPH_Kd3 = 1e-05; - vP1NADPH_Kd3 has mM; - vP2NADP_EqMult = 10000000; - vP2NADP_EqMult has hour_inverse; - vP2NADP_Kd2 = 1e-05; - vP2NADP_Kd2 has mM; - vP2NADPH_EqMult = 10000000; - vP2NADPH_EqMult has hour_inverse; - vP2NADPH_Kd4 = 0.0002; - vP2NADPH_Kd4 has mM; - - // Other declarations: - const compartment_; - - // Unit definitions: - unit substance = 1e-3 mole; - unit time_unit = 3600 second; - unit mM = 1e-3 mole / litre; - unit mM_per_hour = 1e-3 mole / (litre * 3600 second); - unit hour_inverse = 1 / 3600 second; - unit per_mM_hour = litre / (1e-3 mole * 3600 second); - - // Display Names: - substance is "millimole"; - time_unit is "hour"; - compartment_ is "cytoplasm"; - Glcin is "Glucose in"; - Glc6P is "Glucose 6-phosphate"; - Fru6P is "Fructose 6-phosphate"; - Fru16P2 is "Fructose 1,6-phosphate"; - GraP is "Glyceraldehyde 3-phosphate"; - DHAP is "Dihydroxyacetone phosphate"; - Phi is "Phosphate"; - Gri13P2 is "1,3-Bisphospho-D-glycerate"; - Gri3P is "3-Phospho-D-glycerate"; - Gri23P2f is "2,3-Bisphospho-D-glycerate"; - Gri2P is "2-Phospho-D-glycerate"; - PEP is "Phosphoenolpyruvate"; - Pyr is "Pyruvate"; - Lac is "Lactate"; - NADPHf is "NADPH"; - NADPf is "NADP"; - AMPf is "AMP"; - ADPf is "ADP"; - GlcA6P is "Phospho-D-glucono-1,5-lactone"; - Rul5P is "Ribulose 5-phosphate"; - GSSG is "Oxidized Glutathione"; - GSH is "Reduced Glutathione"; - Xul5P is "Xylulose 5-phosphate"; - Rib5P is "Ribose 5-phosphate"; - Sed7P is "Sedoheptulose 7-phosphate"; - E4P is "Erythrose 4-phosphate"; - ATPf is "ATP"; - Mgf is "Mg"; - P1NADP is "Protein1 bound NADP"; - P1f is "Protein1"; - P1NADPH is "Protein1 bound NADPH"; - P2NADP is "Protein2 bound NADP"; - P2f is "Protein2"; - P2NADPH is "Protein2 bound NADPH"; - Lacex is "External Lactate"; - Pyrex is "External Pyruvate"; - Glcout is "Glucose outside"; - Phiex is "Phosphate external"; - vGLT is "Glucose transport"; - vHEX is "Hexokinase"; - vGPI is "Glucosephosphate isomerase"; - vPFK is "Phosphofructokinase"; - vALD is "Aldolase"; - vTPI is "Triosephosphate isomerase"; - vGAPDH is "Glyceraldehyde 3-phosphate dehydrogenase"; - vPGK is "Phosphoglycerate kinase"; - vBPGM is "Bisphosphoglycerate mutase"; - vBPGP is "Bisphosphoglycerate phosphatase"; - vPGM is "Phosphoglycerate mutase"; - vENO is "Enolase"; - vPK is "Pyruvate kinase"; - vLDHNADH is "Lactate dehydrogenase"; - vLDHNADPH is "Lactate dehydrogenase"; - vATPase is "ATPase"; - vAK is "Adenylate kinase"; - vG6PDH is "Glucose 6-phosphate dehydrogenase"; - vPGLDH is "Phosphogluconate dehydrogenase"; - vGSSGRD is "Glutathione reductase"; - vGSHox is "Glutathione oxidation"; - vRibPepi is "Phosphoribulose epimerase"; - vRibPiso is "Ribose phosphate isomerase"; - vTrKet1 is "Transketolase 1"; - vTrAld is "Transaldolase"; - vPPRPPS is "Phosphoribosylpyrophosphate synthetase"; - vTrKet2 is "Transketolase 2"; - vPhiexch is "Phosphate exchange"; - vLacexch is "Lactate exchange"; - vPyrexch is "Pyruvate exchange"; - vMgATP is "MgATP dissociation"; - vMgADP is "MgADP dissociation"; - vMgAMP is "MgAMP dissociation"; - vMgGri23P2 is "MgGri23P2 dissociation"; - vP1NADP is "P1NADP dissociation"; - vP1NADPH is "P1NADPH dissociation"; - vP2NADP is "P2NADP dissociation"; - vP2NADPH is "P2NADPH dissociation"; - - // CV terms: - compartment_ identity "http://identifiers.org/go/GO:0005737" - Glcin identity "http://identifiers.org/chebi/CHEBI:17234", - "http://identifiers.org/kegg.compound/C00293" - MgATP part "http://identifiers.org/chebi/CHEBI:25107", - "http://identifiers.org/chebi/CHEBI:15422" - MgATP part "http://identifiers.org/kegg.compound/C00305", - "http://identifiers.org/kegg.compound/C00002", - "http://identifiers.org/chebi/CHEBI:18420" - Glc6P identity "http://identifiers.org/chebi/CHEBI:17665", - "http://identifiers.org/kegg.compound/C00668" - MgADP part "http://identifiers.org/chebi/CHEBI:25107", - "http://identifiers.org/chebi/CHEBI:16761" - MgADP part "http://identifiers.org/kegg.compound/C00305", - "http://identifiers.org/kegg.compound/C00008", - "http://identifiers.org/chebi/CHEBI:18420" - Fru6P identity "http://identifiers.org/chebi/CHEBI:16084", - "http://identifiers.org/kegg.compound/C05345" - Fru16P2 identity "http://identifiers.org/chebi/CHEBI:28013", - "http://identifiers.org/kegg.compound/C05378" - GraP identity "http://identifiers.org/chebi/CHEBI:29052", - "http://identifiers.org/kegg.compound/C00118" - DHAP identity "http://identifiers.org/chebi/CHEBI:16108", - "http://identifiers.org/kegg.compound/C00111" - Phi identity "http://identifiers.org/chebi/CHEBI:35780" - NAD identity "http://identifiers.org/chebi/CHEBI:15846", - "http://identifiers.org/kegg.compound/C00003" - Gri13P2 identity "http://identifiers.org/chebi/CHEBI:16001", - "http://identifiers.org/kegg.compound/C00236" - NADH identity "http://identifiers.org/chebi/CHEBI:16908", - "http://identifiers.org/kegg.compound/C00004" - Gri3P identity "http://identifiers.org/chebi/CHEBI:17794", - "http://identifiers.org/kegg.compound/C00197" - Gri23P2f identity "http://identifiers.org/chebi/CHEBI:17720", - "http://identifiers.org/kegg.compound/C01159" - Gri2P identity "http://identifiers.org/chebi/CHEBI:17835", - "http://identifiers.org/kegg.compound/C00631" - PEP identity "http://identifiers.org/kegg.compound/C00074", - "http://identifiers.org/chebi/CHEBI:18021" - PEP identity "http://identifiers.org/chebi/CHEBI:18021" - Pyr identity "http://identifiers.org/chebi/CHEBI:15361" - Pyr identity "http://identifiers.org/kegg.compound/C00022", - "http://identifiers.org/chebi/CHEBI:32816" - Lac identity "http://identifiers.org/kegg.compound/C00256", - "http://identifiers.org/chebi/CHEBI:42111" - NADPHf identity "http://identifiers.org/chebi/CHEBI:16474", - "http://identifiers.org/kegg.compound/C00005" - NADPf identity "http://identifiers.org/chebi/CHEBI:18009", - "http://identifiers.org/kegg.compound/C00006" - AMPf identity "http://identifiers.org/chebi/CHEBI:16027", - "http://identifiers.org/kegg.compound/C00020" - ADPf identity "http://identifiers.org/chebi/CHEBI:16761", - "http://identifiers.org/kegg.compound/C00008" - GlcA6P identity "http://identifiers.org/chebi/CHEBI:16938", - "http://identifiers.org/kegg.compound/C01236" - Rul5P identity "http://identifiers.org/chebi/CHEBI:17363", - "http://identifiers.org/kegg.compound/C00199" - GSSG identity "http://identifiers.org/chebi/CHEBI:17858", - "http://identifiers.org/kegg.compound/C00127" - GSH identity "http://identifiers.org/chebi/CHEBI:16856", - "http://identifiers.org/kegg.compound/C00051" - Xul5P identity "http://identifiers.org/chebi/CHEBI:16332", - "http://identifiers.org/kegg.compound/C00231" - Rib5P identity "http://identifiers.org/chebi/CHEBI:17797", - "http://identifiers.org/kegg.compound/C00117" - Sed7P identity "http://identifiers.org/kegg.compound/C05382", - "http://identifiers.org/chebi/CHEBI:15721" - E4P identity "http://identifiers.org/chebi/CHEBI:16897", - "http://identifiers.org/kegg.compound/C00279" - MgAMP part "http://identifiers.org/chebi/CHEBI:25107", - "http://identifiers.org/chebi/CHEBI:16027" - MgAMP part "http://identifiers.org/kegg.compound/C00305", - "http://identifiers.org/kegg.compound/C00020", - "http://identifiers.org/chebi/CHEBI:18420" - ATPf identity "http://identifiers.org/chebi/CHEBI:15422", - "http://identifiers.org/kegg.compound/C00002" - Mgf identity "http://identifiers.org/chebi/CHEBI:25107", - "http://identifiers.org/kegg.compound/C00305" - MgGri23P2 part "http://identifiers.org/chebi/CHEBI:25107", - "http://identifiers.org/chebi/CHEBI:17720" - MgGri23P2 part "http://identifiers.org/kegg.compound/C00305", - "http://identifiers.org/kegg.compound/C01159", - "http://identifiers.org/chebi/CHEBI:18420" - P1NADP part "http://identifiers.org/chebi/CHEBI:36080", - "http://identifiers.org/chebi/CHEBI:18009" - P1NADP part "http://identifiers.org/kegg.compound/C00006", - "http://identifiers.org/kegg.compound/C00017", - "http://identifiers.org/chebi/CHEBI:18009" - P1f hypernym "http://identifiers.org/chebi/CHEBI:36080" - P1f hypernym "http://identifiers.org/kegg.compound/C00017", - "http://identifiers.org/chebi/CHEBI:16541" - P1NADPH part "http://identifiers.org/chebi/CHEBI:16474", - "http://identifiers.org/chebi/CHEBI:36080" - P1NADPH part "http://identifiers.org/kegg.compound/C00005", - "http://identifiers.org/kegg.compound/C00017", - "http://identifiers.org/chebi/CHEBI:16474" - P2NADP part "http://identifiers.org/chebi/CHEBI:18009", - "http://identifiers.org/chebi/CHEBI:36080" - P2NADP part "http://identifiers.org/kegg.compound/C00006", - "http://identifiers.org/kegg.compound/C00017", - "http://identifiers.org/chebi/CHEBI:18009" - P2f hypernym "http://identifiers.org/chebi/CHEBI:36080" - P2f hypernym "http://identifiers.org/kegg.compound/C00017", - "http://identifiers.org/chebi/CHEBI:16541" - P2NADPH part "http://identifiers.org/chebi/CHEBI:16474", - "http://identifiers.org/chebi/CHEBI:36080" - P2NADPH part "http://identifiers.org/kegg.compound/C00005", - "http://identifiers.org/kegg.compound/C00017", - "http://identifiers.org/chebi/CHEBI:16474" - PRPP identity "http://identifiers.org/chebi/CHEBI:17111", - "http://identifiers.org/kegg.compound/C00119" - Lacex identity "http://identifiers.org/kegg.compound/C00256", - "http://identifiers.org/chebi/CHEBI:42111" - Pyrex identity "http://identifiers.org/chebi/CHEBI:32816", - "http://identifiers.org/kegg.compound/C00022" - Glcout identity "http://identifiers.org/chebi/CHEBI:17234", - "http://identifiers.org/kegg.compound/C00293" - Phiex identity "http://identifiers.org/chebi/CHEBI:35780" - vGLT hypernym "http://identifiers.org/go/GO:0046323" - vGLT identity "http://identifiers.org/reactome/REACT_2092" - vHEX hypernym "http://identifiers.org/ec-code/2.7.1.2" - vHEX identity "http://identifiers.org/kegg.reaction/R00299", - "http://identifiers.org/reactome/REACT_1318" - vGPI hypernym "http://identifiers.org/ec-code/5.3.1.9" - vGPI identity "http://identifiers.org/kegg.reaction/R00771", - "http://identifiers.org/reactome/REACT_1164" - vPFK hypernym "http://identifiers.org/ec-code/2.7.1.11" - vPFK identity "http://identifiers.org/kegg.reaction/R00756", - "http://identifiers.org/reactome/REACT_736" - vALD hypernym "http://identifiers.org/ec-code/4.1.2.13" - vALD identity "http://identifiers.org/kegg.reaction/R01070", - "http://identifiers.org/reactome/REACT_1602" - vTPI hypernym "http://identifiers.org/ec-code/5.3.1.1" - vTPI identity "http://identifiers.org/kegg.reaction/R01015", - "http://identifiers.org/reactome/REACT_775" - vGAPDH identity "http://identifiers.org/kegg.reaction/R01061", - "http://identifiers.org/reactome/REACT_1847" - vGAPDH hypernym "http://identifiers.org/ec-code/1.2.1.12" - vPGK identity "http://identifiers.org/kegg.reaction/R01512", - "http://identifiers.org/reactome/REACT_1186" - vPGK hypernym "http://identifiers.org/ec-code/2.7.2.3" - vBPGM hypernym "http://identifiers.org/ec-code/5.4.2.4" - vBPGM identity "http://identifiers.org/kegg.reaction/R01662" - vBPGP identity "http://identifiers.org/kegg.reaction/R01516" - vBPGP hypernym "http://identifiers.org/ec-code/3.1.3.13" - vPGM hypernym "http://identifiers.org/ec-code/5.4.2.1" - vPGM identity "http://identifiers.org/kegg.reaction/R01518", - "http://identifiers.org/reactome/REACT_576" - vENO hypernym "http://identifiers.org/ec-code/4.2.1.11" - vENO identity "http://identifiers.org/kegg.reaction/R00658", - "http://identifiers.org/reactome/REACT_1400" - vPK identity "http://identifiers.org/kegg.reaction/R00200", - "http://identifiers.org/reactome/REACT_1911" - vPK hypernym "http://identifiers.org/ec-code/2.7.1.40" - vLDHNADH identity "http://identifiers.org/kegg.reaction/R00703", - "http://identifiers.org/reactome/REACT_178" - vLDHNADH hypernym "http://identifiers.org/ec-code/1.1.1.27" - vLDHNADPH hypernym "http://identifiers.org/ec-code/1.1.1.27" - vATPase identity "http://identifiers.org/kegg.reaction/R00086" - vATPase hypernym "http://identifiers.org/ec-code/3.6.1.3" - vAK hypernym "http://identifiers.org/ec-code/2.7.4.3" - vAK identity "http://identifiers.org/kegg.reaction/R00127" - vG6PDH hypernym "http://identifiers.org/ec-code/1.1.1.49" - vG6PDH version "http://identifiers.org/reactome/REACT_1868", - "http://identifiers.org/reactome/REACT_1125" - vG6PDH identity "http://identifiers.org/kegg.reaction/R00835" - vPGLDH hypernym "http://identifiers.org/ec-code/1.1.1.44" - vPGLDH part "http://identifiers.org/kegg.reaction/R02035", - "http://identifiers.org/kegg.reaction/R01528" - vPGLDH part "http://identifiers.org/reactome/REACT_2072", - "http://identifiers.org/reactome/REACT_611" - vGSSGRD identity "http://identifiers.org/kegg.reaction/R00094", - "http://identifiers.org/reactome/REACT_2220" - vGSSGRD hypernym "http://identifiers.org/ec-code/1.8.1.7" - vGSHox hypernym "http://identifiers.org/ec-code/1.8.1.7" - vGSHox identity "http://identifiers.org/reactome/REACT_2037" - vRibPepi identity "http://identifiers.org/kegg.reaction/R01529", - "http://identifiers.org/reactome/REACT_1522" - vRibPepi hypernym "http://identifiers.org/ec-code/5.1.3.1" - vRibPiso identity "http://identifiers.org/ec-code/5.3.1.6" - vRibPiso identity "http://identifiers.org/kegg.reaction/R01056", - "http://identifiers.org/reactome/REACT_2033" - vTrKet1 hypernym "http://identifiers.org/ec-code/2.2.1.1" - vTrKet1 identity "http://identifiers.org/kegg.reaction/R01641", - "http://identifiers.org/reactome/REACT_1629" - vTrAld hypernym "http://identifiers.org/ec-code/2.2.1.2" - vTrAld identity "http://identifiers.org/kegg.reaction/R01827", - "http://identifiers.org/reactome/REACT_479" - vPPRPPS hypernym "http://identifiers.org/ec-code/2.7.6.1" - vPPRPPS identity "http://identifiers.org/kegg.reaction/R01049", - "http://identifiers.org/reactome/REACT_2023" - vTrKet2 identity "http://identifiers.org/kegg.reaction/R01830", - "http://identifiers.org/reactome/REACT_1811" - vTrKet2 hypernym "http://identifiers.org/ec-code/2.2.1.1" - vPhiexch hypernym "http://identifiers.org/go/GO:0009935" - vLacexch hypernym "http://identifiers.org/go/GO:0009935" - vPyrexch hypernym "http://identifiers.org/go/GO:0009935" - vMgATP hypernym "http://identifiers.org/go/GO:0006754" - vP1NADPH hypernym "http://identifiers.org/go/GO:0006740" - vP2NADPH hypernym "http://identifiers.org/go/GO:0006735" -end - -Holzhutter2004_Erythrocyte_Metabolism is "Holzhutter2004_Erythrocyte_Metabolism" - -Holzhutter2004_Erythrocyte_Metabolism model_entity_is "http://identifiers.org/biomodels.db/MODEL6624180840" -Holzhutter2004_Erythrocyte_Metabolism model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000070" -Holzhutter2004_Erythrocyte_Metabolism description "http://identifiers.org/pubmed/15233787" -Holzhutter2004_Erythrocyte_Metabolism part "http://identifiers.org/go/GO:0006096", - "http://identifiers.org/go/GO:0006098", - "http://identifiers.org/go/GO:0006749" -Holzhutter2004_Erythrocyte_Metabolism part "http://identifiers.org/kegg.pathway/hsa00010", - "http://identifiers.org/kegg.pathway/hsa00030", - "http://identifiers.org/kegg.pathway/hsa00480" -Holzhutter2004_Erythrocyte_Metabolism part "http://identifiers.org/reactome/REACT_1383", - "http://identifiers.org/reactome/REACT_2220", - "http://identifiers.org/reactome/REACT_1859" -Holzhutter2004_Erythrocyte_Metabolism taxon "http://identifiers.org/taxonomy/9606" diff --git a/BioModelsRAG/data/BIOMD0000000071.txt b/BioModelsRAG/data/BIOMD0000000071.txt deleted file mode 100644 index fbe16c62d7b5ecca2ec2d28d1f2130df73f6ca7e..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000071.txt +++ /dev/null @@ -1,376 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Bakker2001_Glycolysis() - - // Compartments and Species: - compartment tot_cell, glycosome, cytosol, extracellular; - species GlcI in tot_cell, Pg in glycosome, Glc6P in glycosome, Fru6P in glycosome; - species Fru16BP in glycosome, DHAP in tot_cell, GAP in glycosome, NAD in glycosome; - species BPGA13 in glycosome, NADH in glycosome, Pyr in cytosol, Nb in tot_cell; - species Pc in cytosol, $PyrE in extracellular, $Gly in glycosome, $GlcE in extracellular; - species $Gly3P in tot_cell, $Gly3Pc in cytosol, $Gly3Pg in glycosome, $ATPc in cytosol; - species $ADPc in cytosol, $ATPg in glycosome, $ADPg in glycosome, $DHAPg in glycosome; - species $DHAPc in cytosol, $PGAg in glycosome, $PEPc in cytosol; - - // Assignment Rules: - Gly3P := (Gly3Pc*cytosol + Gly3Pg*glycosome)/tot_cell; - Gly3Pc := sumc5 - DHAPc; - Gly3Pg := Gly3Pc*DHAPg/(Keq_anti*DHAPc); - ATPc := ((Pc*(1 - 4*KeqAK) - sumAc) + ((sumAc - (1 - 4*KeqAK)*Pc)^2 + 4*(1 - 4*KeqAK)*KeqAK*Pc^2)^0.5)/(2*(1 - 4*KeqAK)); - ADPc := Pc - 2*ATPc; - ATPg := ((Pg*(1 - 4*KeqAK) - sumAg) + ((sumAg - (1 - 4*KeqAK)*Pg)^2 + 4*(1 - 4*KeqAK)*KeqAK*Pg^2)^0.5)/(2*(1 - 4*KeqAK)); - ADPg := Pg - 2*ATPg; - DHAPg := (DHAP*Vt - DHAPc*Vc)/Vg; - DHAPc := sumc5*(1 + Vc/Vg)*DHAP/(sumc4 + sumc5*Vc/Vg - (BPGA13 + 2*Fru16BP + Fru6P + GAP + Glc6P + Pg)); - Vc := cytosol*Vt/tot_cell; - Vg := glycosome*Vt/tot_cell; - PGAg := Nb*(1 + Vc/Vg)/(1 + (1 + Keq_PGM + Keq_PGM*Keq_ENO)*Vc/Vg); - PEPc := Keq_ENO*Keq_PGM*PGAg; - - // Reactions: - vGlcTr: $GlcE -> GlcI; (tot_cell/Vt)*vGlcTr_Vm1*(GlcE - GlcI)/(vGlcTr_K1Glc + GlcE + GlcI + vGlcTr_afac*GlcE*GlcI/vGlcTr_K1Glc); - vHK: Pg + GlcI => Glc6P; (tot_cell/Vt)*vHK_Vm2*GlcI*ATPg/(vHK_K2ATPg*vHK_K2GlcI*(1 + Glc6P/vHK_K2Glc6P + GlcI/vHK_K2GlcI)*(1 + ATPg/vHK_K2ATPg + ADPg/vHK_K2ADPg)); - vPGI: Glc6P -> Fru6P; (tot_cell/Vt)*vPGI_Vm3*(Glc6P/vPGI_K3Glc6P - Fru6P/vPGI_K3Fru6P)/(1 + Glc6P/vPGI_K3Glc6P + Fru6P/vPGI_K3Fru6P); - vPFK: Pg + Fru6P => Fru16BP; (tot_cell/Vt)*vPFK_K4i1Fru16BP*vPFK_Vm4*Fru6P*ATPg/(vPFK_K4ATPg*vPFK_K4Fru6P*(vPFK_K4i1Fru16BP + Fru16BP)*(1 + Fru16BP/vPFK_K4i2Fru16BP + Fru6P/vPFK_K4Fru6P)*(1 + ATPg/vPFK_K4ATPg)); - vALD: Fru16BP -> GAP + DHAP; (tot_cell/Vt)*(vALD_Vm5f*Fru16BP/(0.009*(1 + ATPg/0.68 + ADPg/1.51 + (sumAg - (ATPg + ADPg))/3.65)) - vALD_Vm5r*GAP*DHAPg/(vALD_K5DHAP*vALD_K5GAP))/(1 + GAP/vALD_K5GAP + DHAPg/vALD_K5DHAP + GAP*DHAPg/(vALD_K5DHAP*vALD_K5GAP) + Fru16BP/(0.009*(1 + ATPg/0.68 + ADPg/1.51 + (sumAg - (ATPg + ADPg))/3.65)) + Fru16BP*GAP/(vALD_K5GAPi*0.009*(1 + ATPg/0.68 + ADPg/1.51 + (sumAg - (ATPg + ADPg))/3.65))); - vTPI: DHAP -> GAP; (tot_cell/Vt)*TPIact*vTPI_Vm6*(DHAPg/vTPI_K6DHAPg - 5.7*GAP/vTPI_K6GAP)/(1 + GAP/vTPI_K6GAP + DHAPg/vTPI_K6DHAPg); - vGAPdh: GAP + NAD -> NADH + BPGA13; (tot_cell/Vt)*vGAPdh_Vm7*(vGAPdh_Vm7f*(GAP*(NAD/vGAPdh_K7GAP/vGAPdh_K7NAD) - (vGAPdh_Vm7r/vGAPdh_Vm7f)*(BPGA13*NADH/vGAPdh_K7BPGA13/vGAPdh_K7NADH))/((1 + GAP/vGAPdh_K7GAP + BPGA13/vGAPdh_K7BPGA13)*(1 + NAD/vGAPdh_K7NAD + NADH/vGAPdh_K7NADH))); - vGDH: DHAP + NADH -> NAD + $Gly3P; (tot_cell/Vt)*vGDH_Vm8*vGDH_Vm8f*(NADH*DHAPg/(vGDH_K8DHAPg*vGDH_K8NADH) - vGDH_Vm8r*NAD*Gly3Pg/(vGDH_K8Gly3Pg*vGDH_K8NAD*vGDH_Vm8f))/((1 + NAD/vGDH_K8NAD + NADH/vGDH_K8NADH)*(1 + DHAPg/vGDH_K8DHAPg + Gly3Pg/vGDH_K8Gly3Pg)); - vGPO: $Gly3P => DHAP; (tot_cell/Vt)*vGPO_Vm9*Gly3Pc/(vGPO_K9Gly3Pc*1 + Gly3Pc); - vPyrTr: Pyr => $PyrE; (tot_cell/Vt)*vPyrTr_Vm10*Pyr/vPyrTr_K10Pyr/(1 + Pyr/vPyrTr_K10Pyr); - vPGK: BPGA13 -> Nb + Pg; (tot_cell/Vt)*vPGK_Vm11*vPGK_Vm11f*(-vPGK_Vm11r*PGAg*ATPg/(vPGK_K11ATPg*vPGK_K11PGA3*vPGK_Vm11f) + BPGA13*ADPg/(vPGK_K11ADPg*vPGK_K11BPGA13))/((1 + BPGA13/vPGK_K11BPGA13 + PGAg/vPGK_K11PGA3)*(1 + ATPg/vPGK_K11ATPg + ADPg/vPGK_K11ADPg)); - vPK: Nb => Pc + Pyr; (tot_cell/Vt)*vPK_Vm12*(PEPc/(0.34*(1 + ADPc/0.57 + ATPc/0.64)))^vPK_n12*ADPc/vPK_K12ADP/((1 + (PEPc/(0.34*(1 + ADPc/0.57 + ATPc/0.64)))^vPK_n12)*(1 + ADPc/vPK_K12ADP)); - vATPase: Pc => ; (tot_cell/Vt)*vATPase_K13*ATPc/ADPc; - vGlyK: $Gly3P -> Pg + $Gly; (tot_cell/Vt)*vGlyK_Vm14*(vGlyK_Vm14f*ADPg*Gly3Pg/(vGlyK_K14ADPg*vGlyK_K14Gly3Pg) - Gly*vGlyK_Vm14r*ATPg/(vGlyK_K14ATPg*vGlyK_K14Gly))/((1 + Gly/vGlyK_K14Gly + Gly3Pg/vGlyK_K14Gly3Pg)*(1 + ATPg/vGlyK_K14ATPg + ADPg/vGlyK_K14ADPg)); - - // Species initializations: - GlcI = 0.0340009; - Pg = 7.63936; - Glc6P = 2.07199; - Fru6P = 0.511773; - Fru16BP = 16.5371; - DHAP = 3.89921; - GAP = 0.0399329; - NAD = 3.95514; - BPGA13 = 0.0326745; - NADH = 0.0448639; - Pyr = 4.77413; - Nb = 1.59603; - Pc = 6.51839; - PyrE = 0; - Gly = 0; - GlcE = 5; - - // Compartment initializations: - tot_cell = 5.7; - glycosome = 0.2446; - cytosol = 5.4554; - extracellular = 1; - - // Variable initializations: - KeqAK = 0.442; - KeqAK has dimensionless; - sumAc = 3.9; - sumAc has mM; - sumAg = 6; - sumAg has mM; - Vt = 5.7; - Vt has microlitre_per_mg; - Vc has microlitre_per_mg; - Vg has microlitre_per_mg; - sumc5 = 5; - sumc5 has mM; - sumc4 = 45; - sumc4 has mM; - Keq_anti = 1; - Keq_anti has dimensionless; - Keq_PGM = 0.187; - Keq_PGM has dimensionless; - Keq_ENO = 6.7; - Keq_ENO has dimensionless; - TPIact = 1; - TPIact has dimensionless; - vGlcTr_Vm1 = 106.2; - vGlcTr_Vm1 has nanomole_per_min_per_mg; - vGlcTr_K1Glc = 2; - vGlcTr_K1Glc has mM; - vGlcTr_afac = 0.75; - vGlcTr_afac has dimensionless; - vHK_Vm2 = 625; - vHK_Vm2 has nanomole_per_min_per_mg; - vHK_K2ATPg = 0.116; - vHK_K2ATPg has mM; - vHK_K2GlcI = 0.1; - vHK_K2GlcI has mM; - vHK_K2Glc6P = 12; - vHK_K2Glc6P has mM; - vHK_K2ADPg = 0.126; - vHK_K2ADPg has mM; - vPGI_Vm3 = 848; - vPGI_Vm3 has nanomole_per_min_per_mg; - vPGI_K3Glc6P = 0.4; - vPGI_K3Glc6P has mM; - vPGI_K3Fru6P = 0.12; - vPGI_K3Fru6P has mM; - vPFK_K4i1Fru16BP = 15.8; - vPFK_K4i1Fru16BP has mM; - vPFK_Vm4 = 780; - vPFK_Vm4 has nanomole_per_min_per_mg; - vPFK_K4ATPg = 0.026; - vPFK_K4ATPg has mM; - vPFK_K4Fru6P = 0.82; - vPFK_K4Fru6P has mM; - vPFK_K4i2Fru16BP = 10.7; - vPFK_K4i2Fru16BP has mM; - vALD_Vm5r = 219.555; - vALD_Vm5r has nanomole_per_min_per_mg; - vALD_K5DHAP = 0.015; - vALD_K5DHAP has mM; - vALD_K5GAP = 0.067; - vALD_K5GAP has mM; - vALD_Vm5f = 184.5; - vALD_Vm5f has nanomole_per_min_per_mg; - vALD_K5GAPi = 0.098; - vALD_K5GAPi has mM; - vTPI_Vm6 = 842; - vTPI_Vm6 has nanomole_per_min_per_mg; - vTPI_K6GAP = 0.25; - vTPI_K6GAP has mM; - vTPI_K6DHAPg = 1.2; - vTPI_K6DHAPg has mM; - vGAPdh_Vm7 = 1; - vGAPdh_Vm7 has dimensionless; - vGAPdh_Vm7f = 1470; - vGAPdh_Vm7f has nanomole_per_min_per_mg; - vGAPdh_K7GAP = 0.15; - vGAPdh_K7GAP has mM; - vGAPdh_K7NAD = 0.45; - vGAPdh_K7NAD has mM; - vGAPdh_Vm7r = 984.9; - vGAPdh_Vm7r has nanomole_per_min_per_mg; - vGAPdh_K7BPGA13 = 0.1; - vGAPdh_K7BPGA13 has mM; - vGAPdh_K7NADH = 0.02; - vGAPdh_K7NADH has mM; - vGDH_Vm8 = 1; - vGDH_Vm8 has dimensionless; - vGDH_Vm8f = 533; - vGDH_Vm8f has nanomole_per_min_per_mg; - vGDH_K8DHAPg = 0.1; - vGDH_K8DHAPg has mM; - vGDH_K8NADH = 0.01; - vGDH_K8NADH has mM; - vGDH_Vm8r = 149.24; - vGDH_Vm8r has nanomole_per_min_per_mg; - vGDH_K8Gly3Pg = 2; - vGDH_K8Gly3Pg has mM; - vGDH_K8NAD = 0.4; - vGDH_K8NAD has mM; - vGPO_Vm9 = 368; - vGPO_Vm9 has nanomole_per_min_per_mg; - vGPO_K9Gly3Pc = 1.7; - vGPO_K9Gly3Pc has mM; - vPyrTr_Vm10 = 200; - vPyrTr_Vm10 has nanomole_per_min_per_mg; - vPyrTr_K10Pyr = 1.96; - vPyrTr_K10Pyr has mM; - vPGK_Vm11 = 1; - vPGK_Vm11 has dimensionless; - vPGK_Vm11f = 640; - vPGK_Vm11f has nanomole_per_min_per_mg; - vPGK_Vm11r = 18.56; - vPGK_Vm11r has nanomole_per_min_per_mg; - vPGK_K11ATPg = 0.29; - vPGK_K11ATPg has mM; - vPGK_K11PGA3 = 1.62; - vPGK_K11PGA3 has mM; - vPGK_K11ADPg = 0.1; - vPGK_K11ADPg has dimensionless; - vPGK_K11BPGA13 = 0.05; - vPGK_K11BPGA13 has dimensionless; - vPK_n12 = 2.5; - vPK_n12 has dimensionless; - vPK_Vm12 = 2600; - vPK_Vm12 has nanomole_per_min_per_mg; - vPK_K12ADP = 0.114; - vPK_K12ADP has mM; - vATPase_K13 = 50; - vATPase_K13 has nanomole_per_min_per_mg; - vGlyK_Vm14 = 1; - vGlyK_Vm14 has dimensionless; - vGlyK_Vm14r = 33400; - vGlyK_Vm14r has nanomole_per_min_per_mg; - vGlyK_K14ATPg = 0.19; - vGlyK_K14ATPg has mM; - vGlyK_K14Gly = 0.12; - vGlyK_K14Gly has mM; - vGlyK_Vm14f = 200; - vGlyK_Vm14f has nanomole_per_min_per_mg; - vGlyK_K14ADPg = 0.12; - vGlyK_K14ADPg has mM; - vGlyK_K14Gly3Pg = 5.1; - vGlyK_K14Gly3Pg has mM; - - // Other declarations: - var Vc, Vg; - const tot_cell, glycosome, cytosol, extracellular, KeqAK, sumAc, sumAg; - const Vt, sumc5, sumc4, Keq_anti, Keq_PGM, Keq_ENO, TPIact; - - // Unit definitions: - unit substance = 1e-9 mole; - unit volume = 1e-6 litre; - unit microlitre_per_mg = 1e-6 litre / 1e-3 gram; - unit nanomole_per_min_per_mg = 1e-9 mole / (60 second * 1e-3 gram); - unit time_unit = 60 second; - unit mM = 1e-9 mole / 1e-6 litre; - - // Display Names: - substance is "nanomole"; - volume is "microlitre"; - time_unit is "minute"; - tot_cell is "total cell"; - GlcI is "Glucose"; - Pg is "Phosphates in Glycosome"; - Glc6P is "Glucose 6-phosphate"; - Fru6P is "Fructose 6-phosphate"; - Fru16BP is "Fructose 1,6-bisphosphate"; - DHAP is "Dihydroxyacetone phosphate"; - GAP is "Glyceraldehyde 3-phosphate"; - BPGA13 is "1,3-bisphosphoglycerate"; - Pyr is "Pyruvate"; - Nb is "3-PGA 2-PGA PEP"; - Pc is "Phosphates cytosol"; - PyrE is "Pyruvate external"; - Gly is "Glycerol"; - GlcE is "Glucose external"; - Gly3P is "Glycerol 3-phosphate"; - Gly3Pc is "Gy3P c."; - Gly3Pg is "Gy3P g."; - ATPc is "ATP cyt."; - ADPc is "ADP cyt."; - ATPg is "ATP gly."; - ADPg is "ADP gly."; - DHAPg is "DHAP gly."; - Vt is "tot volume per mg protein"; - DHAPc is "DHAP cyt."; - PGAg is "3-PGA g."; - PEPc is "PEP c."; - vGlcTr is "Glucose transport"; - vHK is "Hexokinase"; - vPGI is "Glucose-phosphate isomerase"; - vPFK is "Phosphofructokinase"; - vALD is "Aldolase"; - vTPI is "Triosephosphate isomerase"; - vGAPdh is "Glyceraldehyde 3-phosphate dehydrogenase"; - vGDH is "Glycerol 3-phosphate dehydrogenase"; - vGPO is "Glycerol 3-phosphate oxidase"; - vPyrTr is "Pyruvate transport"; - vPGK is "Phosphoglycerate kinase"; - vPK is "Pyruvate kinase"; - vATPase is "ATPase"; - vGlyK is "Glycerol kinase"; - - // CV terms: - glycosome identity "http://identifiers.org/go/GO:0020015" - cytosol identity "http://identifiers.org/go/GO:0005829" - extracellular identity "http://identifiers.org/go/GO:0005576" - GlcI hypernym "http://identifiers.org/chebi/CHEBI:17234", - "http://identifiers.org/kegg.compound/C00293" - Pg hypernym "http://identifiers.org/chebi/CHEBI:35780" - Glc6P identity "http://identifiers.org/chebi/CHEBI:17665", - "http://identifiers.org/kegg.compound/C00668" - Fru6P identity "http://identifiers.org/chebi/CHEBI:16084", - "http://identifiers.org/kegg.compound/C05345" - Fru16BP identity "http://identifiers.org/chebi/CHEBI:28013", - "http://identifiers.org/kegg.compound/C05378" - DHAP identity "http://identifiers.org/chebi/CHEBI:16108", - "http://identifiers.org/kegg.compound/C00111" - GAP identity "http://identifiers.org/chebi/CHEBI:29052", - "http://identifiers.org/kegg.compound/C00118" - NAD identity "http://identifiers.org/chebi/CHEBI:15846", - "http://identifiers.org/kegg.compound/C00003" - BPGA13 identity "http://identifiers.org/chebi/CHEBI:16001", - "http://identifiers.org/kegg.compound/C00236" - NADH identity "http://identifiers.org/chebi/CHEBI:16908", - "http://identifiers.org/kegg.compound/C00004" - Pyr identity "http://identifiers.org/chebi/CHEBI:15361", - "http://identifiers.org/kegg.compound/C00022" - Nb part "http://identifiers.org/kegg.compound/C00197", - "http://identifiers.org/kegg.compound/C00631", - "http://identifiers.org/kegg.compound/C00074" - Nb part "http://identifiers.org/chebi/CHEBI:18021", - "http://identifiers.org/chebi/CHEBI:17794", - "http://identifiers.org/chebi/CHEBI:17835" - Pc hypernym "http://identifiers.org/chebi/CHEBI:35780" - PyrE hypernym "http://identifiers.org/chebi/CHEBI:32816", - "http://identifiers.org/kegg.compound/C00022" - Gly identity "http://identifiers.org/chebi/CHEBI:17754", - "http://identifiers.org/kegg.compound/C00116" - GlcE hypernym "http://identifiers.org/chebi/CHEBI:17234", - "http://identifiers.org/kegg.compound/C00293" - Gly3P identity "http://identifiers.org/chebi/CHEBI:15978", - "http://identifiers.org/kegg.compound/C00093" - Gly3Pc identity "http://identifiers.org/chebi/CHEBI:15978", - "http://identifiers.org/kegg.compound/C00093" - Gly3Pg identity "http://identifiers.org/chebi/CHEBI:15978", - "http://identifiers.org/kegg.compound/C00093" - ATPc identity "http://identifiers.org/chebi/CHEBI:15422", - "http://identifiers.org/kegg.compound/C00002" - ADPc identity "http://identifiers.org/chebi/CHEBI:16761", - "http://identifiers.org/kegg.compound/C00008" - ATPg identity "http://identifiers.org/chebi/CHEBI:15422", - "http://identifiers.org/kegg.compound/C00002" - ADPg identity "http://identifiers.org/chebi/CHEBI:16761", - "http://identifiers.org/kegg.compound/C00008" - DHAPg identity "http://identifiers.org/chebi/CHEBI:16108", - "http://identifiers.org/kegg.compound/C00111" - DHAPc identity "http://identifiers.org/chebi/CHEBI:16108", - "http://identifiers.org/kegg.compound/C00111" - PGAg identity "http://identifiers.org/chebi/CHEBI:18021", - "http://identifiers.org/kegg.compound/C00074" - PEPc identity "http://identifiers.org/chebi/CHEBI:18021", - "http://identifiers.org/kegg.compound/C00074" - vGlcTr hypernym "http://identifiers.org/go/GO:0046323" - vGlcTr homolog "http://identifiers.org/reactome/REACT_2092" - vHK identity "http://identifiers.org/kegg.reaction/R00299" - vHK hypernym "http://identifiers.org/ec-code/2.7.1.2" - vHK homolog "http://identifiers.org/reactome/REACT_1318" - vPGI identity "http://identifiers.org/kegg.reaction/R00771" - vPGI hypernym "http://identifiers.org/ec-code/5.3.1.9" - vPGI homolog "http://identifiers.org/reactome/REACT_1164" - vPFK identity "http://identifiers.org/kegg.reaction/R00756" - vPFK hypernym "http://identifiers.org/ec-code/2.7.1.11" - vPFK homolog "http://identifiers.org/reactome/REACT_736" - vALD identity "http://identifiers.org/kegg.reaction/R01070" - vALD hypernym "http://identifiers.org/ec-code/4.1.2.13" - vALD homolog "http://identifiers.org/reactome/REACT_1602" - vTPI identity "http://identifiers.org/kegg.reaction/R01015" - vTPI hypernym "http://identifiers.org/ec-code/5.3.1.1" - vTPI homolog "http://identifiers.org/reactome/REACT_775" - vGAPdh identity "http://identifiers.org/kegg.reaction/R01061" - vGAPdh hypernym "http://identifiers.org/ec-code/1.2.1.12" - vGAPdh homolog "http://identifiers.org/reactome/REACT_1847" - vGDH identity "http://identifiers.org/kegg.reaction/R00841" - vGDH hypernym "http://identifiers.org/ec-code/3.1.3.21" - vGDH homolog "http://identifiers.org/reactome/REACT_1146" - vGPO identity "http://identifiers.org/kegg.reaction/R00846" - vGPO hypernym "http://identifiers.org/ec-code/1.1.3.21" - vPGK hypernym "http://identifiers.org/ec-code/2.7.2.3" - vPK hypernym "http://identifiers.org/ec-code/2.7.1.40" - vPK identity "http://identifiers.org/kegg.reaction/R00200" - vPK homolog "http://identifiers.org/reactome/REACT_1911" - vATPase hypernym "http://identifiers.org/go/GO:0006200" - vGlyK identity "http://identifiers.org/kegg.reaction/R00847" - vGlyK hypernym "http://identifiers.org/ec-code/2.7.1.30" -end - -Bakker2001_Glycolysis is "Bakker2001_Glycolysis" - -Bakker2001_Glycolysis model_entity_is "http://identifiers.org/biomodels.db/MODEL6624099213" -Bakker2001_Glycolysis model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000071" -Bakker2001_Glycolysis description "http://identifiers.org/pubmed/11415442" -Bakker2001_Glycolysis origin "http://identifiers.org/biomodels.db/MODEL1101100000", - "http://identifiers.org/pubmed/10468568" -Bakker2001_Glycolysis taxon "http://identifiers.org/taxonomy/5691" -Bakker2001_Glycolysis identity "http://identifiers.org/kegg.pathway/tbr00010" -Bakker2001_Glycolysis hypernym "http://identifiers.org/go/GO:0006096" -Bakker2001_Glycolysis homolog "http://identifiers.org/reactome/REACT_1383" diff --git a/BioModelsRAG/data/BIOMD0000000072.txt b/BioModelsRAG/data/BIOMD0000000072.txt deleted file mode 100644 index 1bd28ae80ad6624b3b3bbad22aad6317a7da3786..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000072.txt +++ /dev/null @@ -1,102 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Model_1() - - // Compartments and Species: - compartment cell; - species L in cell, R in cell, G in cell, Gbg in cell, Gd in cell, Ga in cell; - species RL in cell; - - // Reactions: - reaction_0: L + R -> RL; cell*(reaction_0_k1*L*R - reaction_0_k2*RL); - reaction_1: => R; cell*reaction_1_v; - reaction_2: R => ; cell*reaction_2_k1*R; - reaction_3: Gd + Gbg => G; cell*reaction_3_k1*Gd*Gbg; - reaction_4: G => Ga + Gbg; cell*reaction_4_k1*RL*G; - reaction_5: RL => ; cell*reaction_5_k1*RL; - reaction_6: Ga => Gd; cell*reaction_6_k1*Ga; - - // Species initializations: - L = 6.02e+17; - R = 10000; - G = 7000; - Gbg = 3000; - Gd = 3000; - Ga = 0; - RL = 0; - - // Compartment initializations: - cell = 1; - - // Variable initializations: - reaction_0_k1 = 3.32e-18; - reaction_0_k2 = 0.01; - reaction_1_v = 4; - reaction_2_k1 = 0.0004; - reaction_3_k1 = 1; - reaction_4_k1 = 1e-05; - reaction_5_k1 = 0.004; - reaction_6_k1 = 0.11; - - // Other declarations: - const cell; - - // Unit definitions: - unit substance = item; - - // Display Names: - L is "Ligand"; - R is "Receptor"; - G is "Inactive heterotrimeric G-protein"; - Gbg is "Free levels of G-beta-gamma"; - Gd is "G-alpha-GDP"; - Ga is "G-alpha-GTP"; - RL is "Receptor-Ligand"; - reaction_0 is "Ligand-Receptor Association"; - reaction_1 is "Receptor Synthesis"; - reaction_2 is "Receptor Degradation"; - reaction_3 is "Heterotrimeric G-Protein Formation"; - reaction_4 is "G-protein Activation"; - reaction_5 is "Receptor-Ligand Degradation"; - reaction_6 is "G-protein Inactivation "; - - // CV terms: - cell hypernym "http://identifiers.org/go/GO:0005623" - L version "http://identifiers.org/uniprot/P34165", - "http://identifiers.org/uniprot/P34166" - L hypernym "http://identifiers.org/interpro/IPR006742" - R identity "http://identifiers.org/uniprot/P06842" - G hypernym "http://identifiers.org/go/GO:0005834" - Gbg identity "http://identifiers.org/go/GO:0031680" - Gd part "http://identifiers.org/interpro/IPR001019", - "http://identifiers.org/kegg.compound/C00035" - Gd part "http://identifiers.org/chebi/CHEBI:17552", - "http://identifiers.org/interpro/IPR001019" - Ga part "http://identifiers.org/interpro/IPR001019", - "http://identifiers.org/kegg.compound/C00044" - Ga part "http://identifiers.org/chebi/CHEBI:15996", - "http://identifiers.org/interpro/IPR001019" - RL hypernym "http://identifiers.org/go/GO:0043235" - RL part "http://identifiers.org/uniprot/P34165", - "http://identifiers.org/uniprot/P06842" - RL part "http://identifiers.org/uniprot/P34166", - "http://identifiers.org/uniprot/P06842" - reaction_0 hypernym "http://identifiers.org/go/GO:0004934", - "http://identifiers.org/go/GO:0001664", - "http://identifiers.org/go/GO:0005102" - reaction_1 hypernym "http://identifiers.org/go/GO:0006412" - reaction_2 hypernym "http://identifiers.org/go/GO:0030163" - reaction_3 hypernym "http://identifiers.org/go/GO:0001965", - "http://identifiers.org/go/GO:0031683" - reaction_4 hypernym "http://identifiers.org/go/GO:0004930", - "http://identifiers.org/go/GO:0043241" - reaction_5 hypernym "http://identifiers.org/go/GO:0030163" - reaction_6 hypernym "http://identifiers.org/go/GO:0003924" -end - -Model_1 is "Yi2003_GproteinCycle" - -Model_1 model_entity_is "http://identifiers.org/biomodels.db/MODEL9468910329" -Model_1 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000072" -Model_1 description "http://identifiers.org/pubmed/12960402" -Model_1 hypernym "http://identifiers.org/go/GO:0031684" -Model_1 taxon "http://identifiers.org/taxonomy/4932" diff --git a/BioModelsRAG/data/BIOMD0000000073.txt b/BioModelsRAG/data/BIOMD0000000073.txt deleted file mode 100644 index 949d653f1bff3ee88f6518a6d51895026221ff7f..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000073.txt +++ /dev/null @@ -1,364 +0,0 @@ -// Created by libAntimony v2.13.0 -function function_3(Vs, B, n, K) - Vs*B^n/(K^n + B^n); -end - -function_3 is "Activation of gene" - -function function_2(V, substrate, Km) - V*substrate/(Km + substrate); -end - -function_2 is "Michaelis-Menten(irreversible)" - -function function_1(k, mRNA) - k*mRNA; -end - -function_1 is "mRNA translated into protein" - -function function_0(vsb, K, m, Bn) - vsb*K^m/(K^m + Bn^m); -end - -function_0 is "Inhibition of gene" - - -model *Model_1() - - // Compartments and Species: - compartment cell; - species species_0 in cell, species_1 in cell, species_2 in cell, species_3 in cell; - species species_4 in cell, species_5 in cell, species_6 in cell, species_7 in cell; - species species_8 in cell, species_9 in cell, species_10 in cell, species_11 in cell; - species species_12 in cell, species_13 in cell, species_14 in cell, species_15 in cell; - - // Reactions: - reaction_0: => species_0; cell*function_0(reaction_0_vsb, reaction_0_K, reaction_0_m, species_3); - reaction_1: => species_1; cell*function_1(reaction_1_k, species_0); - reaction_2: species_0 => ; cell*reaction_2_k1*species_0; - reaction_3: species_1 => species_2; cell*function_2(reaction_3_V, species_1, reaction_3_Km); - reaction_4: species_1 -> species_3; cell*(reaction_4_k1*species_1 - reaction_4_k2*species_3); - reaction_5: => species_4; cell*function_1(reaction_5_k, species_5); - reaction_6: species_5 => ; cell*reaction_6_k1*species_5; - reaction_7: species_4 => species_6; cell*function_2(reaction_7_V, species_4, reaction_7_Km); - reaction_8: species_6 => ; cell*function_2(reaction_8_V, species_6, reaction_8_Km); - reaction_9: => species_7; cell*function_3(reaction_9_Vs, species_3, reaction_9_n, reaction_9_K); - reaction_10: => species_8; cell*function_1(reaction_10_k, species_7); - reaction_11: species_9 => ; cell*function_2(reaction_11_V, species_9, reaction_11_Km); - reaction_12: species_8 => species_9; cell*function_2(reaction_12_V, species_8, reaction_12_Km); - reaction_13: species_4 + species_8 -> species_10; cell*(reaction_13_k1*species_4*species_8 - reaction_13_k2*species_10); - reaction_14: species_10 => species_11; cell*function_2(reaction_14_V, species_10, reaction_14_Km); - reaction_15: species_11 => ; cell*function_2(reaction_15_V, species_11, reaction_15_Km); - reaction_16: species_10 -> species_12; cell*(reaction_16_k1*species_10 - reaction_16_k2*species_12); - reaction_17: species_14 => ; cell*reaction_17_k1*species_14; - reaction_18: species_2 => ; cell*reaction_18_k1*species_2; - reaction_19: species_13 => ; cell*reaction_19_k1*species_13; - reaction_20: => species_5; cell*function_3(reaction_20_Vs, species_3, reaction_20_n, reaction_20_K); - reaction_21: species_12 => species_14; cell*function_2(reaction_21_V, species_12, reaction_21_Km); - reaction_22: species_7 => ; cell*reaction_22_k1*species_7; - reaction_23: species_12 + species_3 -> species_15; cell*(reaction_23_k1*species_12*species_3 - reaction_23_k2*species_15); - reaction_24: species_0 => ; cell*function_2(reaction_24_V, species_0, reaction_24_Km); - reaction_25: species_5 => ; cell*function_2(reaction_25_V, species_5, reaction_25_Km); - reaction_26: species_7 => ; cell*function_2(reaction_26_V, species_7, reaction_26_Km); - reaction_27: species_8 => ; cell*reaction_27_k1*species_8; - reaction_28: species_4 => ; cell*reaction_28_k1*species_4; - reaction_29: species_9 => ; cell*reaction_29_k1*species_9; - reaction_30: species_6 => ; cell*reaction_30_k1*species_6; - reaction_31: species_11 => ; cell*reaction_31_k1*species_11; - reaction_32: species_10 => ; cell*reaction_32_k1*species_10; - reaction_33: species_14 => ; cell*function_2(reaction_33_V, species_14, reaction_33_Km); - reaction_34: species_1 => ; cell*reaction_34_k1*species_1; - reaction_35: species_2 => ; cell*function_2(reaction_35_V, species_2, reaction_35_Km); - reaction_36: species_3 => species_13; cell*function_2(reaction_36_V, species_3, reaction_36_Km); - reaction_37: species_13 => ; cell*function_2(reaction_37_V, species_13, reaction_37_Km); - reaction_38: species_15 => ; cell*reaction_38_k1*species_15; - reaction_39: species_15 => ; cell*function_2(reaction_39_V, species_15, reaction_39_Km); - reaction_40: species_3 => ; cell*reaction_40_k1*species_3; - reaction_41: species_2 => species_1; cell*function_2(reaction_41_V, species_2, reaction_41_Km); - reaction_42: species_13 => species_3; cell*function_2(reaction_42_V, species_13, reaction_42_Km); - reaction_43: species_6 => species_4; cell*function_2(reaction_43_V, species_6, reaction_43_Km); - reaction_44: species_9 => species_8; cell*function_2(reaction_44_V, species_9, reaction_44_Km); - reaction_45: species_14 => species_12; cell*function_2(reaction_45_V, species_14, reaction_45_Km); - reaction_46: species_12 => ; cell*reaction_46_k1*species_12; - reaction_47: species_11 => species_10; cell*function_2(reaction_47_V, species_11, reaction_47_Km); - - // Species initializations: - species_0 = 9; - species_1 = 2; - species_2 = 0; - species_3 = 1.9; - species_4 = 0; - species_5 = 1.4; - species_6 = 0; - species_7 = 1.6; - species_8 = 0; - species_9 = 0; - species_10 = 0; - species_11 = 0; - species_12 = 1; - species_13 = 0; - species_14 = 0; - species_15 = 0; - - // Compartment initializations: - cell = 1; - - // Variable initializations: - reaction_0_vsb = 1; - reaction_0_K = 2.2; - reaction_0_m = 2; - reaction_1_k = 0.12; - reaction_2_k1 = 0.01; - reaction_3_V = 0.5; - reaction_3_Km = 0.1; - reaction_4_k1 = 0.4; - reaction_4_k2 = 0.2; - reaction_5_k = 1.6; - reaction_6_k1 = 0.01; - reaction_7_V = 0.6; - reaction_7_Km = 0.1; - reaction_8_V = 0.7; - reaction_8_Km = 0.3; - reaction_9_Vs = 1.5; - reaction_9_n = 4; - reaction_9_K = 0.7; - reaction_10_k = 0.6; - reaction_11_V = 0.7; - reaction_11_Km = 0.3; - reaction_12_V = 0.4; - reaction_12_Km = 0.1; - reaction_13_k1 = 0.4; - reaction_13_k2 = 0.2; - reaction_14_V = 0.4; - reaction_14_Km = 0.1; - reaction_15_V = 0.7; - reaction_15_Km = 0.3; - reaction_16_k1 = 0.4; - reaction_16_k2 = 0.2; - reaction_17_k1 = 0.01; - reaction_18_k1 = 0.01; - reaction_19_k1 = 0.01; - reaction_20_Vs = 1.1; - reaction_20_n = 4; - reaction_20_K = 0.6; - reaction_21_V = 0.4; - reaction_21_Km = 0.1; - reaction_22_k1 = 0.01; - reaction_23_k1 = 0.5; - reaction_23_k2 = 0.1; - reaction_24_V = 0.8; - reaction_24_Km = 0.4; - reaction_25_V = 1; - reaction_25_Km = 0.4; - reaction_26_V = 1.1; - reaction_26_Km = 0.31; - reaction_27_k1 = 0.01; - reaction_28_k1 = 0.12; - reaction_29_k1 = 0.01; - reaction_30_k1 = 0.01; - reaction_31_k1 = 0.01; - reaction_32_k1 = 0.01; - reaction_33_V = 0.7; - reaction_33_Km = 0.3; - reaction_34_k1 = 0.01; - reaction_35_V = 0.5; - reaction_35_Km = 0.3; - reaction_36_V = 0.5; - reaction_36_Km = 0.1; - reaction_37_V = 0.6; - reaction_37_Km = 0.3; - reaction_38_k1 = 0.01; - reaction_39_V = 0.8; - reaction_39_Km = 0.3; - reaction_40_k1 = 0.01; - reaction_41_V = 0.1; - reaction_41_Km = 0.1; - reaction_42_V = 0.2; - reaction_42_Km = 0.1; - reaction_43_V = 0.1; - reaction_43_Km = 0.1; - reaction_44_V = 0.3; - reaction_44_Km = 0.1; - reaction_45_V = 0.1; - reaction_45_Km = 0.1; - reaction_46_k1 = 0.01; - reaction_47_V = 0.1; - reaction_47_Km = 0.1; - - // Other declarations: - const cell; - - // Unit definitions: - unit time_unit = 3600 second; - unit substance = 1e-9 mole; - - // Display Names: - species_0 is "Mb"; - species_1 is "Bc"; - species_2 is "Bcp"; - species_3 is "Bn"; - species_4 is "Cc"; - species_5 is "Mc"; - species_6 is "Ccp"; - species_7 is "Mp"; - species_8 is "Pc"; - species_9 is "Pcp"; - species_10 is "PCc"; - species_11 is "PCcp"; - species_12 is "PCn"; - species_13 is "Bnp"; - species_14 is "PCnp"; - species_15 is "In"; - reaction_0 is "Mb synthesized"; - reaction_1 is "Mb translated into protein"; - reaction_2 is "Mb nonspecific degradation"; - reaction_3 is "Bc phosphorylation"; - reaction_4 is "Bc transfered from cytosolic to nuclear"; - reaction_5 is "Mc translated into protein"; - reaction_6 is "Mc nonspecific degradation"; - reaction_7 is "Cc phosphorylation"; - reaction_8 is "Ccp specific degradation"; - reaction_9 is "Mp synthesis"; - reaction_10 is "Mp translated into protein"; - reaction_11 is "Pcp specific degradation"; - reaction_12 is "Pc phosphorylation"; - reaction_13 is "Cc and Pc produce complex Per_Cry"; - reaction_14 is "PCc phosphorylation"; - reaction_15 is "PCcp specific degradation"; - reaction_16 is "PCc transfered into nuclear"; - reaction_17 is "PCnp nonspecific degradation"; - reaction_18 is "Bcp nonspecific degradation"; - reaction_19 is "Bnp nonspecific degradation"; - reaction_20 is "Mc synthesis"; - reaction_21 is "PCn phosphorylation"; - reaction_22 is "Mp nonspecific degradation"; - reaction_23 is "Per_Cry and Clock_Bmal form inactive complex"; - reaction_24 is "Mb specific degradation"; - reaction_25 is "Mc specific degradation"; - reaction_26 is "Mp specific degradation"; - reaction_27 is "Pc nonspecific degradation"; - reaction_28 is "Cc nonspecific degradation"; - reaction_29 is "Pcp nonspecific degradation"; - reaction_30 is "Ccp nonspecific degradation"; - reaction_31 is "PCcp nonspecific degradation"; - reaction_32 is "PCc nonspecific degradation"; - reaction_33 is "PCnp specific degradation"; - reaction_34 is "Bc nonspecific degradation"; - reaction_35 is "Bcp specific degradation"; - reaction_36 is "Bn phosphorylation"; - reaction_37 is "Bnp specific degradation"; - reaction_38 is "In nonspecific degration"; - reaction_39 is "In specific degradation"; - reaction_40 is "Bn nonspecific degradation"; - reaction_41 is "Bcp dephosphorylation"; - reaction_42 is "Bnp dephosphorylation"; - reaction_43 is "Ccp dephosphorylation"; - reaction_44 is "Pcp dephosphorylation"; - reaction_45 is "PCnp dephosphorylation"; - reaction_46 is "PCn nonspecific degradation"; - reaction_47 is "PCcp dephosphorylation"; - - // CV terms: - cell hypernym "http://identifiers.org/go/GO:0005622" - species_0 hypernym "http://identifiers.org/chebi/CHEBI:33699" - species_1 version "http://identifiers.org/uniprot/O00327" - species_2 version "http://identifiers.org/uniprot/O00327" - species_3 identity "http://identifiers.org/uniprot/O00327" - species_4 version "http://identifiers.org/uniprot/Q16526", - "http://identifiers.org/uniprot/Q8IV71" - species_5 hypernym "http://identifiers.org/chebi/CHEBI:33699" - species_6 version "http://identifiers.org/uniprot/Q16526", - "http://identifiers.org/uniprot/Q8IV71" - species_7 hypernym "http://identifiers.org/chebi/CHEBI:33699" - species_8 version "http://identifiers.org/uniprot/O15534", - "http://identifiers.org/uniprot/O15055", - "http://identifiers.org/uniprot/P56645" - species_9 version "http://identifiers.org/uniprot/O15534", - "http://identifiers.org/uniprot/O15055", - "http://identifiers.org/uniprot/P56645" - species_10 part "http://identifiers.org/uniprot/O15534", - "http://identifiers.org/uniprot/Q16526" - species_10 part "http://identifiers.org/uniprot/O15055", - "http://identifiers.org/uniprot/Q16526" - species_10 part "http://identifiers.org/uniprot/P56645", - "http://identifiers.org/uniprot/Q16526" - species_11 part "http://identifiers.org/uniprot/O15534", - "http://identifiers.org/uniprot/Q16526" - species_11 part "http://identifiers.org/uniprot/O15055", - "http://identifiers.org/uniprot/Q8IV71" - species_11 part "http://identifiers.org/uniprot/P56645", - "http://identifiers.org/uniprot/Q8IV71" - species_12 part "http://identifiers.org/uniprot/O15534", - "http://identifiers.org/uniprot/Q16526" - species_12 part "http://identifiers.org/uniprot/P56645", - "http://identifiers.org/uniprot/Q16526" - species_12 part "http://identifiers.org/uniprot/P56645", - "http://identifiers.org/uniprot/Q8IV71" - species_13 version "http://identifiers.org/uniprot/O00327" - species_14 part "http://identifiers.org/uniprot/O15534", - "http://identifiers.org/uniprot/Q16526" - species_14 part "http://identifiers.org/uniprot/O15534", - "http://identifiers.org/uniprot/Q8IV71" - species_14 part "http://identifiers.org/uniprot/P56645", - "http://identifiers.org/uniprot/Q8IV71" - reaction_0 hypernym "http://identifiers.org/go/GO:0045892" - reaction_1 hypernym "http://identifiers.org/go/GO:0006412" - reaction_2 hypernym "http://identifiers.org/go/GO:0044257" - reaction_3 hypernym "http://identifiers.org/go/GO:0006468" - reaction_4 hypernym "http://identifiers.org/go/GO:0000060" - reaction_5 hypernym "http://identifiers.org/go/GO:0006412" - reaction_6 hypernym "http://identifiers.org/go/GO:0044257" - reaction_7 hypernym "http://identifiers.org/go/GO:0006468" - reaction_8 hypernym "http://identifiers.org/go/GO:0008233" - reaction_9 identity "http://identifiers.org/go/GO:0045893" - reaction_10 hypernym "http://identifiers.org/go/GO:0006412" - reaction_11 hypernym "http://identifiers.org/go/GO:0008233" - reaction_12 hypernym "http://identifiers.org/go/GO:0006468" - reaction_13 hypernym "http://identifiers.org/go/GO:0043623" - reaction_14 hypernym "http://identifiers.org/go/GO:0006468" - reaction_15 hypernym "http://identifiers.org/go/GO:0008233" - reaction_16 hypernym "http://identifiers.org/go/GO:0000060" - reaction_17 hypernym "http://identifiers.org/go/GO:0044257" - reaction_18 hypernym "http://identifiers.org/go/GO:0044257" - reaction_19 hypernym "http://identifiers.org/go/GO:0044257" - reaction_20 hypernym "http://identifiers.org/go/GO:0045893" - reaction_21 hypernym "http://identifiers.org/go/GO:0006468" - reaction_22 hypernym "http://identifiers.org/go/GO:0044257" - reaction_23 hypernym "http://identifiers.org/go/GO:0043623" - reaction_24 hypernym "http://identifiers.org/go/GO:0008233" - reaction_25 hypernym "http://identifiers.org/go/GO:0008233" - reaction_26 hypernym "http://identifiers.org/go/GO:0008233" - reaction_27 hypernym "http://identifiers.org/go/GO:0044257" - reaction_28 hypernym "http://identifiers.org/go/GO:0044257" - reaction_29 hypernym "http://identifiers.org/go/GO:0044257" - reaction_30 hypernym "http://identifiers.org/go/GO:0044257" - reaction_31 hypernym "http://identifiers.org/go/GO:0044257" - reaction_32 hypernym "http://identifiers.org/go/GO:0044257" - reaction_33 hypernym "http://identifiers.org/go/GO:0008233" - reaction_34 hypernym "http://identifiers.org/go/GO:0044257" - reaction_35 hypernym "http://identifiers.org/go/GO:0008233" - reaction_36 hypernym "http://identifiers.org/go/GO:0006468" - reaction_37 hypernym "http://identifiers.org/go/GO:0008233" - reaction_38 hypernym "http://identifiers.org/go/GO:0044257" - reaction_39 parthood "http://identifiers.org/go/GO:0008233" - reaction_40 hypernym "http://identifiers.org/go/GO:0044257" - reaction_41 hypernym "http://identifiers.org/go/GO:0006470" - reaction_42 hypernym "http://identifiers.org/go/GO:0006470" - reaction_43 hypernym "http://identifiers.org/go/GO:0006470" - reaction_44 hypernym "http://identifiers.org/go/GO:0006470" - reaction_45 hypernym "http://identifiers.org/go/GO:0006470" - reaction_46 hypernym "http://identifiers.org/go/GO:0044257" - reaction_47 hypernym "http://identifiers.org/go/GO:0006470", - "http://identifiers.org/go/GO:0016311" -end - -Model_1 is "Leloup2003_CircClock_DD" - -Model_1 model_entity_is "http://identifiers.org/biomodels.db/MODEL1109528188" -Model_1 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000073" -Model_1 description "http://identifiers.org/pubmed/12775757" -Model_1 origin "http://identifiers.org/biomodels.db/BIOMD0000000021" -Model_1 taxon "http://identifiers.org/taxonomy/40674" -Model_1 version "http://identifiers.org/kegg.pathway/hsa04710" -Model_1 hypernym "http://identifiers.org/go/GO:0042752" diff --git a/BioModelsRAG/data/BIOMD0000000074.txt b/BioModelsRAG/data/BIOMD0000000074.txt deleted file mode 100644 index 23c41b7421dbae25dc28076ef262660ed06c3570..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000074.txt +++ /dev/null @@ -1,411 +0,0 @@ -// Created by libAntimony v2.13.0 -function function_3(Vs, B, n, K) - Vs*B^n/(K^n + B^n); -end - -function_3 is "Activation of gene" - -function function_2(V, substrate, Km) - V*substrate/(Km + substrate); -end - -function_2 is "Michaelis-Menten (irreversible)" - -function function_1(k, mRNA) - k*mRNA; -end - -function_1 is "mRNA translated into protein" - -function function_0(vsb, K, m, Bn) - vsb*K^m/(K^m + Bn^m); -end - -function_0 is "Inhibition of gene" - - -model *Model_1() - - // Compartments and Species: - compartment compartment_0; - species species_0 in compartment_0, species_1 in compartment_0, species_2 in compartment_0; - species species_3 in compartment_0, species_4 in compartment_0, species_5 in compartment_0; - species species_6 in compartment_0, species_7 in compartment_0, species_8 in compartment_0; - species species_9 in compartment_0, species_10 in compartment_0, species_11 in compartment_0; - species species_12 in compartment_0, species_13 in compartment_0, species_14 in compartment_0; - species species_15 in compartment_0, species_16 in compartment_0, species_17 in compartment_0; - species species_18 in compartment_0; - - // Reactions: - reaction_0: => species_0; compartment_0*function_0(reaction_0_vsb, reaction_0_K, reaction_0_m, species_18); - reaction_1: => species_1; compartment_0*function_1(reaction_1_k, species_0); - reaction_2: species_0 => ; compartment_0*reaction_2_k1*species_0; - reaction_3: species_1 => species_2; compartment_0*function_2(reaction_3_V, species_1, reaction_3_Km); - reaction_4: species_1 -> species_3; compartment_0*(reaction_4_k1*species_1 - reaction_4_k2*species_3); - reaction_5: => species_4; compartment_0*function_1(reaction_5_k, species_5); - reaction_6: species_5 => ; compartment_0*reaction_6_k1*species_5; - reaction_7: species_4 => species_6; compartment_0*function_2(reaction_7_V, species_4, reaction_7_Km); - reaction_8: species_6 => ; compartment_0*function_2(reaction_8_V, species_6, reaction_8_Km); - reaction_9: => species_7; compartment_0*function_3(reaction_9_Vs, species_3, reaction_9_n, reaction_9_K); - reaction_10: => species_8; compartment_0*function_1(reaction_10_k, species_7); - reaction_11: species_9 => ; compartment_0*function_2(reaction_11_V, species_9, reaction_11_Km); - reaction_12: species_8 => species_9; compartment_0*function_2(reaction_12_V, species_8, reaction_12_Km); - reaction_13: species_4 + species_8 -> species_10; compartment_0*(reaction_13_k1*species_4*species_8 - reaction_13_k2*species_10); - reaction_14: species_10 => species_11; compartment_0*function_2(reaction_14_V, species_10, reaction_14_Km); - reaction_15: species_11 => ; compartment_0*function_2(reaction_15_V, species_11, reaction_15_Km); - reaction_16: species_10 -> species_12; compartment_0*(reaction_16_k1*species_10 - reaction_16_k2*species_12); - reaction_17: species_14 => ; compartment_0*reaction_17_k1*species_14; - reaction_18: species_2 => ; compartment_0*reaction_18_k1*species_2; - reaction_19: species_13 => ; compartment_0*reaction_19_k1*species_13; - reaction_20: => species_5; compartment_0*function_3(reaction_20_Vs, species_3, reaction_20_n, reaction_20_K); - reaction_21: species_12 => species_14; compartment_0*function_2(reaction_21_V, species_12, reaction_21_Km); - reaction_22: species_7 => ; compartment_0*reaction_22_k1*species_7; - reaction_23: species_12 + species_3 -> species_15; compartment_0*(reaction_23_k1*species_12*species_3 - reaction_23_k2*species_15); - reaction_24: species_0 => ; compartment_0*function_2(reaction_24_V, species_0, reaction_24_Km); - reaction_25: species_5 => ; compartment_0*function_2(reaction_25_V, species_5, reaction_25_Km); - reaction_26: species_7 => ; compartment_0*function_2(reaction_26_V, species_7, reaction_26_Km); - reaction_27: species_8 => ; compartment_0*reaction_27_k1*species_8; - reaction_28: species_4 => ; compartment_0*reaction_28_k1*species_4; - reaction_29: species_9 => ; compartment_0*reaction_29_k1*species_9; - reaction_30: species_6 => ; compartment_0*reaction_30_k1*species_6; - reaction_31: species_11 => ; compartment_0*reaction_31_k1*species_11; - reaction_32: species_10 => ; compartment_0*reaction_32_k1*species_10; - reaction_33: species_14 => ; compartment_0*function_2(reaction_33_V, species_14, reaction_33_Km); - reaction_34: species_1 => ; compartment_0*reaction_34_k1*species_1; - reaction_35: species_2 => ; compartment_0*function_2(reaction_35_V, species_2, reaction_35_Km); - reaction_36: species_3 => species_13; compartment_0*function_2(reaction_36_V, species_3, reaction_36_Km); - reaction_37: species_13 => ; compartment_0*function_2(reaction_37_V, species_13, reaction_37_Km); - reaction_38: species_15 => ; compartment_0*reaction_38_k1*species_15; - reaction_39: species_15 => ; compartment_0*function_2(reaction_39_V, species_15, reaction_39_Km); - reaction_40: species_3 => ; compartment_0*reaction_40_k1*species_3; - reaction_41: species_2 => species_1; compartment_0*function_2(reaction_41_V, species_2, reaction_41_Km); - reaction_42: species_13 => species_3; compartment_0*function_2(reaction_42_V, species_13, reaction_42_Km); - reaction_43: species_6 => species_4; compartment_0*function_2(reaction_43_V, species_6, reaction_43_Km); - reaction_44: species_9 => species_8; compartment_0*function_2(reaction_44_V, species_9, reaction_44_Km); - reaction_45: species_14 => species_12; compartment_0*function_2(reaction_45_V, species_14, reaction_45_Km); - reaction_46: species_12 => ; compartment_0*reaction_46_k1*species_12; - reaction_47: species_11 => species_10; compartment_0*function_2(reaction_47_V, species_11, reaction_47_Km); - reaction_48: => species_16; compartment_0*function_3(reaction_48_Vs, species_3, reaction_48_n, reaction_48_K); - reaction_49: species_16 => ; compartment_0*reaction_49_k1*species_16; - reaction_50: species_16 => ; compartment_0*function_2(reaction_50_V, species_16, reaction_50_Km); - reaction_51: => species_17; compartment_0*function_1(reaction_51_k, species_16); - reaction_52: species_17 -> species_18; compartment_0*(reaction_52_k1*species_17 - reaction_52_k2*species_18); - reaction_53: species_17 => ; compartment_0*function_2(reaction_53_V, species_17, reaction_53_Km); - reaction_54: species_17 => ; compartment_0*reaction_54_k1*species_17; - reaction_55: species_18 => ; compartment_0*function_2(reaction_55_V, species_18, reaction_55_Km); - reaction_56: species_18 => ; compartment_0*reaction_56_k1*species_18; - - // Species initializations: - species_0 = 0; - species_1 = 0; - species_2 = 0; - species_3 = 0; - species_4 = 0; - species_5 = 0; - species_6 = 0; - species_7 = 0; - species_8 = 0; - species_9 = 0; - species_10 = 0; - species_11 = 0; - species_12 = 0; - species_13 = 0; - species_14 = 0; - species_15 = 0; - species_16 = 0; - species_17 = 0; - species_18 = 0; - - // Compartment initializations: - compartment_0 = 1; - - // Variable initializations: - reaction_0_vsb = 1.8; - reaction_0_K = 1; - reaction_0_m = 2; - reaction_1_k = 0.32; - reaction_2_k1 = 0.02; - reaction_3_V = 1.4; - reaction_3_Km = 1.006; - reaction_4_k1 = 0.8; - reaction_4_k2 = 0.4; - reaction_5_k = 3.2; - reaction_6_k1 = 0.02; - reaction_7_V = 1.2; - reaction_7_Km = 1.006; - reaction_8_V = 1.4; - reaction_8_Km = 0.3; - reaction_9_Vs = 2.4; - reaction_9_n = 2; - reaction_9_K = 0.6; - reaction_10_k = 1.2; - reaction_11_V = 3.4; - reaction_11_Km = 0.3; - reaction_12_V = 9.6; - reaction_12_Km = 1.006; - reaction_13_k1 = 0.8; - reaction_13_k2 = 0.4; - reaction_14_V = 2.4; - reaction_14_Km = 1.006; - reaction_15_V = 1.4; - reaction_15_Km = 0.3; - reaction_16_k1 = 0.8; - reaction_16_k2 = 0.4; - reaction_17_k1 = 0.02; - reaction_18_k1 = 0.02; - reaction_19_k1 = 0.02; - reaction_20_Vs = 2.2; - reaction_20_n = 2; - reaction_20_K = 0.6; - reaction_21_V = 2.4; - reaction_21_Km = 1.006; - reaction_22_k1 = 0.02; - reaction_23_k1 = 1; - reaction_23_k2 = 0.2; - reaction_24_V = 1.3; - reaction_24_Km = 0.4; - reaction_25_V = 2; - reaction_25_Km = 0.4; - reaction_26_V = 2.2; - reaction_26_Km = 0.3; - reaction_27_k1 = 0.02; - reaction_28_k1 = 0.02; - reaction_29_k1 = 0.02; - reaction_30_k1 = 0.02; - reaction_31_k1 = 0.02; - reaction_32_k1 = 0.02; - reaction_33_V = 1.4; - reaction_33_Km = 0.3; - reaction_34_k1 = 0.02; - reaction_35_V = 3; - reaction_35_Km = 0.3; - reaction_36_V = 1.4; - reaction_36_Km = 1.006; - reaction_37_V = 3; - reaction_37_Km = 0.3; - reaction_38_k1 = 0.02; - reaction_39_V = 1.6; - reaction_39_Km = 0.3; - reaction_40_k1 = 0.02; - reaction_41_V = 0.2; - reaction_41_Km = 0.1; - reaction_42_V = 0.4; - reaction_42_Km = 0.1; - reaction_43_V = 0.2; - reaction_43_Km = 0.1; - reaction_44_V = 0.6; - reaction_44_Km = 0.1; - reaction_45_V = 0.2; - reaction_45_Km = 0.1; - reaction_46_k1 = 0.02; - reaction_47_V = 0.2; - reaction_47_Km = 0.1; - reaction_48_Vs = 1.6; - reaction_48_n = 2; - reaction_48_K = 0.6; - reaction_49_k1 = 0.02; - reaction_50_V = 1.6; - reaction_50_Km = 0.4; - reaction_51_k = 1.7; - reaction_52_k1 = 0.8; - reaction_52_k2 = 0.4; - reaction_53_V = 4.4; - reaction_53_Km = 0.3; - reaction_54_k1 = 0.02; - reaction_55_V = 0.8; - reaction_55_Km = 0.3; - reaction_56_k1 = 0.02; - - // Other declarations: - const compartment_0; - - // Unit definitions: - unit time_unit = 3600 second; - unit substance = 1e-9 mole; - - // Display Names: - compartment_0 is "cell"; - species_0 is "Mb"; - species_1 is "Bc"; - species_2 is "Bcp"; - species_3 is "Bn"; - species_4 is "Cc"; - species_5 is "Mc"; - species_6 is "Ccp"; - species_7 is "Mp"; - species_8 is "Pc"; - species_9 is "Pcp"; - species_10 is "PCc"; - species_11 is "PCcp"; - species_12 is "PCn"; - species_13 is "Bnp"; - species_14 is "PCnp"; - species_15 is "In"; - species_16 is "Mr"; - species_17 is "Rc"; - species_18 is "Rn"; - reaction_0 is "Mb synthesized"; - reaction_1 is "Mb translated into protein"; - reaction_2 is "Mb nonspecific degradation"; - reaction_3 is "Bc phosphorylation"; - reaction_4 is "Bc transfered from cytosolic to nuclear"; - reaction_5 is "Mc translated into protein"; - reaction_6 is "Mc nonspecific degradation"; - reaction_7 is "Cc phosphorylation"; - reaction_8 is "Ccp specific degradation"; - reaction_9 is "Mp synthesis"; - reaction_10 is "Mp translated into protein"; - reaction_11 is "Pcp specific degradation"; - reaction_12 is "Pc phospholation"; - reaction_13 is "Cc and Pc produce PCc"; - reaction_14 is "PCc phospholation"; - reaction_15 is "PCcp specific degradation"; - reaction_16 is "PCc transfered into nuclear"; - reaction_17 is "PCnp nonspecific degradation"; - reaction_18 is "Bcp nonspecific degradation"; - reaction_19 is "Bnp nonspecific degradation"; - reaction_20 is "Mc synthesis"; - reaction_21 is "PCn phospholation"; - reaction_22 is "Mp nonspecific degradation"; - reaction_23 is "Per_Cry and Clock_Bmal form inactive complex"; - reaction_24 is "Mb specific degradation"; - reaction_25 is "Mc specific degradation"; - reaction_26 is "Mp specific degradation"; - reaction_27 is "Pc nonspecific degradation"; - reaction_28 is "Cc nonspecific degradation"; - reaction_29 is "Pcp nonspecific degradation"; - reaction_30 is "Ccp nonspecific degradation"; - reaction_31 is "PCcp nonspecific degradation"; - reaction_32 is "PCc nonspecific degradation"; - reaction_33 is "PCnp specific degradation"; - reaction_34 is "Bc nonspecific degradation"; - reaction_35 is "Bcp specific degradation"; - reaction_36 is "Bn phospholation"; - reaction_37 is "Bnp specific degradation"; - reaction_38 is "In nonspecific degration"; - reaction_39 is "In specific degradation"; - reaction_40 is "Bn nonspecific degradation"; - reaction_41 is "Bcp dephospholation"; - reaction_42 is "Bnp dephospholation"; - reaction_43 is "Ccp dephospholation"; - reaction_44 is "Pcp dephospholation"; - reaction_45 is "PCnp dephospholation"; - reaction_46 is "PCn nonspecific degradation"; - reaction_47 is "PCcp dephospholation"; - reaction_48 is "Mr synthesized"; - reaction_49 is "Mr nonspecific degradation"; - reaction_50 is "Mr specific degradation"; - reaction_51 is "Mr translated into protein"; - reaction_52 is "Rc transfered into nuclear"; - reaction_53 is "Rc specific degradation"; - reaction_54 is "Rc nonspecific degradation"; - reaction_55 is "Rn specific degradation"; - reaction_56 is "Rn nonspecific degradation"; - - // CV terms: - compartment_0 hypernym "http://identifiers.org/go/GO:0005623" - species_0 hypernym "http://identifiers.org/chebi/CHEBI:33699" - species_1 version "http://identifiers.org/uniprot/O00327" - species_2 version "http://identifiers.org/uniprot/O00327" - species_3 version "http://identifiers.org/uniprot/O00327" - species_4 version "http://identifiers.org/uniprot/Q16526", - "http://identifiers.org/uniprot/Q8IV71" - species_5 hypernym "http://identifiers.org/chebi/CHEBI:33699" - species_6 version "http://identifiers.org/uniprot/Q16526", - "http://identifiers.org/uniprot/Q8IV71" - species_7 hypernym "http://identifiers.org/chebi/CHEBI:33699" - species_8 version "http://identifiers.org/uniprot/O15534", - "http://identifiers.org/uniprot/O15055", - "http://identifiers.org/uniprot/P56645" - species_9 version "http://identifiers.org/uniprot/O15534", - "http://identifiers.org/uniprot/O15055", - "http://identifiers.org/uniprot/P56645" - species_10 part "http://identifiers.org/uniprot/O15534", - "http://identifiers.org/uniprot/Q16526" - species_10 part "http://identifiers.org/uniprot/P56645", - "http://identifiers.org/uniprot/Q8IV71" - species_11 part "http://identifiers.org/uniprot/O15534", - "http://identifiers.org/uniprot/Q16526" - species_11 part "http://identifiers.org/uniprot/P56645", - "http://identifiers.org/uniprot/Q8IV71" - species_12 part "http://identifiers.org/uniprot/O15534", - "http://identifiers.org/uniprot/Q16526" - species_12 part "http://identifiers.org/uniprot/P56645", - "http://identifiers.org/uniprot/Q8IV71" - species_13 version "http://identifiers.org/uniprot/O00327" - species_14 part "http://identifiers.org/uniprot/O15534", - "http://identifiers.org/uniprot/Q16526" - species_14 part "http://identifiers.org/uniprot/O15055", - "http://identifiers.org/uniprot/Q16526" - species_14 part "http://identifiers.org/uniprot/P56645", - "http://identifiers.org/uniprot/Q8IV71" - species_16 hypernym "http://identifiers.org/chebi/CHEBI:33699" - species_17 version "http://identifiers.org/uniprot/Q6EEZ7" - species_18 version "http://identifiers.org/uniprot/Q6EEZ7" - reaction_0 hypernym "http://identifiers.org/go/GO:0045892" - reaction_1 hypernym "http://identifiers.org/go/GO:0006412" - reaction_2 hypernym "http://identifiers.org/go/GO:0044257" - reaction_3 hypernym "http://identifiers.org/go/GO:0006468" - reaction_4 hypernym "http://identifiers.org/go/GO:0000060" - reaction_5 hypernym "http://identifiers.org/go/GO:0006412" - reaction_6 hypernym "http://identifiers.org/go/GO:0044257" - reaction_7 hypernym "http://identifiers.org/go/GO:0006468" - reaction_8 hypernym "http://identifiers.org/go/GO:0008233" - reaction_9 hypernym "http://identifiers.org/go/GO:0045893" - reaction_11 hypernym "http://identifiers.org/go/GO:0008233" - reaction_12 hypernym "http://identifiers.org/go/GO:0006468" - reaction_13 hypernym "http://identifiers.org/go/GO:0043623" - reaction_14 hypernym "http://identifiers.org/go/GO:0006468" - reaction_15 hypernym "http://identifiers.org/go/GO:0008233" - reaction_16 hypernym "http://identifiers.org/go/GO:0000060" - reaction_17 hypernym "http://identifiers.org/go/GO:0044257" - reaction_18 hypernym "http://identifiers.org/go/GO:0044257" - reaction_19 hypernym "http://identifiers.org/go/GO:0044257" - reaction_20 parthood "http://identifiers.org/go/GO:0045893" - reaction_21 hypernym "http://identifiers.org/go/GO:0006468" - reaction_22 hypernym "http://identifiers.org/go/GO:0044257" - reaction_23 hypernym "http://identifiers.org/go/GO:0043623" - reaction_24 hypernym "http://identifiers.org/go/GO:0008233" - reaction_25 hypernym "http://identifiers.org/go/GO:0008233" - reaction_26 hypernym "http://identifiers.org/go/GO:0008233" - reaction_27 hypernym "http://identifiers.org/go/GO:0044257" - reaction_28 hypernym "http://identifiers.org/go/GO:0044257" - reaction_29 hypernym "http://identifiers.org/go/GO:0044257" - reaction_30 hypernym "http://identifiers.org/go/GO:0044257" - reaction_31 hypernym "http://identifiers.org/go/GO:0044257" - reaction_32 hypernym "http://identifiers.org/go/GO:0044257" - reaction_33 hypernym "http://identifiers.org/go/GO:0008233" - reaction_34 hypernym "http://identifiers.org/go/GO:0044257" - reaction_35 hypernym "http://identifiers.org/go/GO:0008233" - reaction_36 hypernym "http://identifiers.org/go/GO:0006468" - reaction_37 hypernym "http://identifiers.org/go/GO:0008233" - reaction_38 hypernym "http://identifiers.org/go/GO:0044257" - reaction_39 hypernym "http://identifiers.org/go/GO:0008233" - reaction_40 hypernym "http://identifiers.org/go/GO:0044257" - reaction_41 hypernym "http://identifiers.org/go/GO:0006470" - reaction_42 hypernym "http://identifiers.org/go/GO:0006470" - reaction_43 parthood "http://identifiers.org/go/GO:0006470" - reaction_44 hypernym "http://identifiers.org/go/GO:0006470" - reaction_45 hypernym "http://identifiers.org/go/GO:0006470" - reaction_46 hypernym "http://identifiers.org/go/GO:0044257" - reaction_47 hypernym "http://identifiers.org/go/GO:0006470" - reaction_48 parthood "http://identifiers.org/go/GO:0045893" - reaction_49 hypernym "http://identifiers.org/go/GO:0044257" - reaction_50 hypernym "http://identifiers.org/go/GO:0008233" - reaction_51 hypernym "http://identifiers.org/go/GO:0006412" - reaction_52 hypernym "http://identifiers.org/go/GO:0000060" - reaction_53 hypernym "http://identifiers.org/go/GO:0008233" - reaction_54 hypernym "http://identifiers.org/go/GO:0044257" - reaction_55 hypernym "http://identifiers.org/go/GO:0008233" - reaction_56 hypernym "http://identifiers.org/go/GO:0044257" -end - -Model_1 is "Leloup2003_CircClock_DD_REV-ERBalpha" - -Model_1 model_entity_is "http://identifiers.org/biomodels.db/MODEL1272626224" -Model_1 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000074" -Model_1 description "http://identifiers.org/pubmed/12775757" -Model_1 origin "http://identifiers.org/biomodels.db/BIOMD0000000021" -Model_1 version "http://identifiers.org/kegg.pathway/hsa04710" -Model_1 hypernym "http://identifiers.org/go/GO:0042752" -Model_1 taxon "http://identifiers.org/taxonomy/40674" diff --git a/BioModelsRAG/data/BIOMD0000000075.txt b/BioModelsRAG/data/BIOMD0000000075.txt deleted file mode 100644 index 2cac405edf083b801c56a30a6c519e3b316afdc8..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000075.txt +++ /dev/null @@ -1,250 +0,0 @@ -// Created by libAntimony v2.13.0 -function Function_for_PIPSyn(PI_PM, Ratebasal_PIPsyn_PIPSyn, Ratestim_PIPsyn_PIPSyn) - (Ratebasal_PIPsyn_PIPSyn + Ratestim_PIPsyn_PIPSyn)*PI_PM; -end - -Function_for_PIPSyn is "Function for PIPSyn" - -function Function_for_PLCact(KfPLCact, PLC_PM, PLC_act_PM, krPLCact, signal_PLCact, stim_PM) - KfPLCact*PLC_PM*stim_PM*signal_PLCact + -(krPLCact*PLC_act_PM); -end - -Function_for_PLCact is "Function for PLCact" - -function Function_for_IP3_PHGFP(IP3_Cyt, IP3_PHGFP_Cyt, KMOLE, PH_GFP_Cyt, kf_IP3PH_IP3_PHGFP, kr_IP3PH_IP3_PHGFP) - (kf_IP3PH_IP3_PHGFP*0.00166112956810631*IP3_Cyt*0.00166112956810631*PH_GFP_Cyt + -(kr_IP3PH_IP3_PHGFP*0.00166112956810631*IP3_PHGFP_Cyt))*1*(1/KMOLE); -end - -Function_for_IP3_PHGFP is "Function for IP3-PHGFP" - -function Function_for_PIP2_PH(PH_GFP_Cyt, PIP2_PHGFP_PM, PIP2_PM, PM, kf_PIP2PH_PIP2_PH, kr_PIP2PH_PIP2_PH) - (kf_PIP2PH_PIP2_PH*0.00166112956810631*PH_GFP_Cyt*PIP2_PM + -(kr_PIP2PH_PIP2_PH*PIP2_PHGFP_PM))*PM; -end - -Function_for_PIP2_PH is "Function for PIP2_PH" - -function Function_for_PIP2_PH_hyd(PIP2_PHGFP_PM, PLC_act_PM, PM, k_PIP2PHhyd) - k_PIP2PHhyd*PLC_act_PM*PIP2_PHGFP_PM*PM; -end - -Function_for_PIP2_PH_hyd is "Function for PIP2_PH_hyd" - -function Function_for_IP3deg(IP3_Cyt, IP3_basal, KMOLE, kIP3deg) - kIP3deg*(0.00166112956810631*IP3_Cyt + -IP3_basal)*1*(1/KMOLE); -end - -Function_for_IP3deg is "Function for IP3deg" - -function Function_for_PIP2Syn(PIP_PM, Rate_PIP2SynStim_PIP2Syn, Rate_PIP2Synbasal_PIP2Syn) - (Rate_PIP2Synbasal_PIP2Syn + Rate_PIP2SynStim_PIP2Syn)*PIP_PM; -end - -Function_for_PIP2Syn is "Function for PIP2Syn" - -function Function_for_PIP2_hyd(PIP2_PM, PLC_act_PM, PM, k_PIP2hyd) - k_PIP2hyd*PIP2_PM*PLC_act_PM*PM; -end - -Function_for_PIP2_hyd is "Function for PIP2_hyd" - - -model *Xu2003_Phosphoinositide_turnover() - - // Compartments and Species: - compartment Extracellular, PM, Cytosol, NM, Nucleus; - species PIP2_PHGFP_PM in PM, PH_GFP_Cyt in Cytosol, PI_PM in PM, $stim_PM in PM; - species IP3_PHGFP_Cyt in Cytosol, PIP2_PM in PM, PIP_PM in PM, DAG_PM in PM; - species $hv_Cytosol in Cytosol, $IP3X_Cytosol in Cytosol, PLC_PM in PM; - species PLC_act_PM in PM, IP3_Cyt in Cytosol; - - // Assignment Rules: - Ratebasal_PIPsyn_PIPSyn := piecewise(0.581*kBasalSynPIP_PIPSyn*(-1 + exp((PIP_basal_PIPSyn + -PIP_PM)*(1/PIP_basal_PIPSyn))), PIP_PM < PIP_basal_PIPSyn, 0); - Ratestim_PIPsyn_PIPSyn := piecewise(kStimSynPIP_PIPSyn*exp(-((time + -tauPIPsyn_PIPSyn)*(1/PIPsyndecay_PIPSyn))), time > tauPIPsyn_PIPSyn, 0); - signal_PLCact := piecewise(exp(-((time + -tau0_PLCact)*(1/stimdecay_PLCact))), time > tau0_PLCact, 0); - kr_PIP2PH_PIP2_PH := kf_PIP2PH_PIP2_PH*KdPIP2PH_PIP2_PH; - Rate_PIP2Synbasal_PIP2Syn := piecewise(0.581*kBasalSynPIP2_PIP2Syn*(-1 + exp((PIP2_basal_PIP2Syn + -PIP2_PM)*(1/PIP2_basal_PIP2Syn))), PIP2_PM < PIP2_basal_PIP2Syn, 0); - Rate_PIP2SynStim_PIP2Syn := piecewise(kStimSynPIP2_PIP2Syn*exp(-((time + -tauPIP2syn_PIP2Syn)*(1/PIP2syndecay_PIP2Syn))), time > tauPIP2syn_PIP2Syn, 0); - kr_IP3PH_IP3_PHGFP := kf_IP3PH_IP3_PHGFP*KdIP3PH_IP3_PHGFP; - - // Reactions: - PIPSyn: PI_PM -> PIP_PM; PM*Function_for_PIPSyn(PI_PM, Ratebasal_PIPsyn_PIPSyn, Ratestim_PIPsyn_PIPSyn); - PIP2_hyd: PIP2_PM -> DAG_PM + IP3_Cyt; Function_for_PIP2_hyd(PIP2_PM, PLC_act_PM, PM, PIP2_hyd_k_PIP2hyd); - PLCact: PLC_PM -> PLC_act_PM; PM*Function_for_PLCact(PLCact_KfPLCact, PLC_PM, PLC_act_PM, PLCact_krPLCact, signal_PLCact, stim_PM); - PIP2_PH_hyd: PIP2_PHGFP_PM -> PH_GFP_Cyt + IP3_Cyt + DAG_PM; Function_for_PIP2_PH_hyd(PIP2_PHGFP_PM, PLC_act_PM, PM, PIP2_PH_hyd_k_PIP2PHhyd); - PIP2_PH: PH_GFP_Cyt + PIP2_PM -> PIP2_PHGFP_PM; Function_for_PIP2_PH(PH_GFP_Cyt, PIP2_PHGFP_PM, PIP2_PM, PM, kf_PIP2PH_PIP2_PH, kr_PIP2PH_PIP2_PH); - IP3deg: IP3_Cyt -> ; Cytosol*Function_for_IP3deg(IP3_Cyt, IP3deg_IP3_basal, KMOLE, IP3deg_kIP3deg); - PIP2Syn: PIP_PM -> PIP2_PM; PM*Function_for_PIP2Syn(PIP_PM, Rate_PIP2SynStim_PIP2Syn, Rate_PIP2Synbasal_PIP2Syn); - IP3_PHGFP: IP3_Cyt + PH_GFP_Cyt -> IP3_PHGFP_Cyt; Cytosol*Function_for_IP3_PHGFP(IP3_Cyt, IP3_PHGFP_Cyt, KMOLE, PH_GFP_Cyt, kf_IP3PH_IP3_PHGFP, kr_IP3PH_IP3_PHGFP); - - // Species initializations: - PIP2_PHGFP_PM = 0; - PIP2_PHGFP_PM has substance_per_volume; - PH_GFP_Cyt = 0; - PH_GFP_Cyt has substance_per_volume; - PI_PM = 142857; - PI_PM has substance_per_volume; - stim_PM = 1; - stim_PM has substance_per_volume; - IP3_PHGFP_Cyt = 0; - IP3_PHGFP_Cyt has substance_per_volume; - PIP2_PM = 4000; - PIP2_PM has substance_per_volume; - PIP_PM = 2857; - PIP_PM has substance_per_volume; - DAG_PM = 2000; - DAG_PM has substance_per_volume; - hv_Cytosol = 0; - hv_Cytosol has substance_per_volume; - IP3X_Cytosol = 0; - IP3X_Cytosol has substance_per_volume; - PLC_PM = 100; - PLC_PM has substance_per_volume; - PLC_act_PM = 0; - PLC_act_PM has substance_per_volume; - IP3_Cyt = 96.32; - IP3_Cyt has substance_per_volume; - - // Compartment initializations: - Extracellular = 0.277777777777778; - Extracellular has volume; - PM = 0.5555555555556; - PM has volume; - Cytosol = 1; - Cytosol has volume; - NM = 0.111111111111111; - NM has volume; - Nucleus = 0.111111111111111; - Nucleus has volume; - - // Variable initializations: - KMOLE = 0.00166112956810631; - KMOLE has unit_0; - PIP_basal_PIPSyn = 2857; - PIP_basal_PIPSyn has unit_1; - kBasalSynPIP_PIPSyn = 0.0055; - kBasalSynPIP_PIPSyn has unit_2; - kStimSynPIP_PIPSyn = 0.019; - kStimSynPIP_PIPSyn has unit_2; - tauPIPsyn_PIPSyn = 0.05; - tauPIPsyn_PIPSyn has unit_3; - PIPsyndecay_PIPSyn = 1; - PIPsyndecay_PIPSyn has unit_3; - Ratebasal_PIPsyn_PIPSyn has unit_2; - Ratestim_PIPsyn_PIPSyn has unit_2; - tau0_PLCact = 0.05; - tau0_PLCact has unit_3; - stimdecay_PLCact = 1; - stimdecay_PLCact has unit_3; - signal_PLCact has unit_4; - kf_PIP2PH_PIP2_PH = 0.12; - kf_PIP2PH_PIP2_PH has unit_5; - KdPIP2PH_PIP2_PH = 2; - KdPIP2PH_PIP2_PH has unit_6; - kr_PIP2PH_PIP2_PH has unit_2; - kStimSynPIP2_PIP2Syn = 0.92; - kStimSynPIP2_PIP2Syn has unit_2; - tauPIP2syn_PIP2Syn = 0.05; - tauPIP2syn_PIP2Syn has unit_3; - PIP2syndecay_PIP2Syn = 1; - PIP2syndecay_PIP2Syn has unit_3; - PIP2_basal_PIP2Syn = 4000; - PIP2_basal_PIP2Syn has unit_1; - kBasalSynPIP2_PIP2Syn = 0.048; - kBasalSynPIP2_PIP2Syn has unit_2; - Rate_PIP2Synbasal_PIP2Syn has unit_2; - Rate_PIP2SynStim_PIP2Syn has unit_2; - kf_IP3PH_IP3_PHGFP = 10; - kf_IP3PH_IP3_PHGFP has unit_5; - KdIP3PH_IP3_PHGFP = 2; - KdIP3PH_IP3_PHGFP has unit_6; - kr_IP3PH_IP3_PHGFP has unit_2; - PIP2_hyd_k_PIP2hyd = 2.4; - PLCact_KfPLCact = 0.0005; - PLCact_krPLCact = 0.1; - PIP2_PH_hyd_k_PIP2PHhyd = 0; - IP3deg_IP3_basal = 0.16; - IP3deg_kIP3deg = 0.08; - - // Other declarations: - var Ratebasal_PIPsyn_PIPSyn, Ratestim_PIPsyn_PIPSyn, signal_PLCact, kr_PIP2PH_PIP2_PH; - var Rate_PIP2Synbasal_PIP2Syn, Rate_PIP2SynStim_PIP2Syn, kr_IP3PH_IP3_PHGFP; - const Extracellular, PM, Cytosol, NM, Nucleus, KMOLE, PIP_basal_PIPSyn; - const kBasalSynPIP_PIPSyn, kStimSynPIP_PIPSyn, tauPIPsyn_PIPSyn, PIPsyndecay_PIPSyn; - const tau0_PLCact, stimdecay_PLCact, kf_PIP2PH_PIP2_PH, KdPIP2PH_PIP2_PH; - const kStimSynPIP2_PIP2Syn, tauPIP2syn_PIP2Syn, PIP2syndecay_PIP2Syn, PIP2_basal_PIP2Syn; - const kBasalSynPIP2_PIP2Syn, kf_IP3PH_IP3_PHGFP, KdIP3PH_IP3_PHGFP; - - // Unit definitions: - unit length = metre; - unit area = (1e-6 metre)^2; - unit volume = litre; - unit time_unit = time_unit; - unit substance = item; - unit unit_0 = 1e-18 avogadro; - unit unit_1 = item / (1e6 metre)^2; - unit unit_2 = 1 / second; - unit unit_3 = second; - unit unit_4 = 1 / dimensionless^-0; - unit unit_5 = metre^3 / ((1e-9 dimensionless)^-0 * mole * second); - unit unit_6 = item * avogadro / ((1e-6 dimensionless)^-0 * litre); - unit extent = substance; - unit substance_per_volume = item / litre; - - // Display Names: - time_unit is "time"; - unit_0 is "aAvogadro"; - unit_1 is "#/Mm²"; - unit_2 is "1/s"; - unit_3 is "s"; - unit_4 is "1"; - unit_5 is "µl/(mol*s)"; - unit_6 is "µmol/l"; - IP3_PHGFP is "IP3-PHGFP"; - - // CV terms: - Extracellular identity "http://identifiers.org/go/GO:0005576" - PM identity "http://identifiers.org/go/GO:0005886" - Cytosol identity "http://identifiers.org/go/GO:0005622" - NM identity "http://identifiers.org/go/GO:0031965" - Nucleus identity "http://identifiers.org/go/GO:0005634" - PIP2_PHGFP_PM part "http://identifiers.org/chebi/CHEBI:18348" - PIP2_PHGFP_PM part "http://identifiers.org/interpro/IPR011584" - PIP2_PHGFP_PM part "http://identifiers.org/interpro/IPR001849" - PH_GFP_Cyt part "http://identifiers.org/interpro/IPR001849" - PH_GFP_Cyt part "http://identifiers.org/interpro/IPR011584" - PI_PM hypernym "http://identifiers.org/chebi/CHEBI:28874" - stim_PM property "http://identifiers.org/opb/OPB_01072" - IP3_PHGFP_Cyt part "http://identifiers.org/interpro/IPR001849" - IP3_PHGFP_Cyt part "http://identifiers.org/chebi/CHEBI:16595" - IP3_PHGFP_Cyt part "http://identifiers.org/interpro/IPR011584" - PIP2_PM hypernym "http://identifiers.org/chebi/CHEBI:18348" - PIP_PM hypernym "http://identifiers.org/chebi/CHEBI:26034" - DAG_PM hypernym "http://identifiers.org/chebi/CHEBI:18035" - hv_Cytosol hypernym "http://identifiers.org/chebi/CHEBI:30212" - IP3X_Cytosol identity "http://identifiers.org/pato/PATO:0002355" - IP3X_Cytosol hypernym "http://identifiers.org/chebi/CHEBI:16595" - PLC_PM hypernym "http://identifiers.org/uniprot/Q8K4S1" - PLC_act_PM hypernym "http://identifiers.org/uniprot/Q8K4S1" - PLC_act_PM property "http://identifiers.org/ec-code/3.1.4.11" - IP3_Cyt hypernym "http://identifiers.org/chebi/CHEBI:16595" - PIPSyn hypernym "http://identifiers.org/biomodels.sbo/SBO:0000216" - PIP2_hyd hypernym "http://identifiers.org/biomodels.sbo/SBO:0000182" - PLCact hypernym "http://identifiers.org/biomodels.sbo/SBO:0000170" - PIP2_PH_hyd hypernym "http://identifiers.org/biomodels.sbo/SBO:0000182" - PIP2_PH hypernym "http://identifiers.org/biomodels.sbo/SBO:0000182" - IP3deg hypernym "http://identifiers.org/biomodels.sbo/SBO:0000179" - PIP2Syn hypernym "http://identifiers.org/biomodels.sbo/SBO:0000216" - IP3_PHGFP hypernym "http://identifiers.org/biomodels.sbo/SBO:0000182" -end - -Xu2003_Phosphoinositide_turnover is "Xu2003 - Phosphoinositide turnover" - -Xu2003_Phosphoinositide_turnover model_entity_is "http://identifiers.org/biomodels.db/MODEL3095606944", - "http://identifiers.org/biomodels.db/BIOMD0000000075" -Xu2003_Phosphoinositide_turnover identity "http://identifiers.org/biomodels.db/MODEL3095606944" -Xu2003_Phosphoinositide_turnover identity "http://identifiers.org/biomodels.db/BIOMD0000000075" -Xu2003_Phosphoinositide_turnover parthood "http://identifiers.org/kegg.pathway/map04070" -Xu2003_Phosphoinositide_turnover hypernym "http://identifiers.org/go/GO:0046488" -Xu2003_Phosphoinositide_turnover container "http://identifiers.org/bto/BTO:0000931" -Xu2003_Phosphoinositide_turnover taxon "http://identifiers.org/taxonomy/10090" -Xu2003_Phosphoinositide_turnover description "http://identifiers.org/pubmed/12771127" diff --git a/BioModelsRAG/data/BIOMD0000000076.txt b/BioModelsRAG/data/BIOMD0000000076.txt deleted file mode 100644 index 5cef2d80124aaaa19830781a37f7814b80356884..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000076.txt +++ /dev/null @@ -1,97 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Cronwright2002_Glycerol_Synthesis() - - // Compartments and Species: - compartment compartment_; - species G3P in compartment_, $Gly in compartment_, $DHAP in compartment_; - - // Reactions: - Gpd_p: $DHAP -> G3P; (compartment_*Gpd_p_Vf1/(Gpd_p_K1nadh*Gpd_p_K1dhap))*(Gpd_p_NADH*DHAP - Gpd_p_NAD*G3P/Gpd_p_Keq1)/((1 + Gpd_p_F16BP/Gpd_p_K1f16bp + Gpd_p_ATP/Gpd_p_K1atp + Gpd_p_ADP/Gpd_p_K1adp)*(1 + Gpd_p_NADH/Gpd_p_K1nadh + Gpd_p_NAD/Gpd_p_K1nad)*(1 + DHAP/Gpd_p_K1dhap + G3P/Gpd_p_K1g3p)); - Gpp_p: G3P -> $Gly; compartment_*Gpp_p_V2*G3P/Gpp_p_K2g3p/((1 + G3P/Gpp_p_K2g3p)*(1 + Gpp_p_Phi/Gpp_p_K2phi)); - - // Species initializations: - G3P = 0; - Gly = 15.1; - DHAP = 0.59; - - // Compartment initializations: - compartment_ = 1; - - // Variable initializations: - Gpd_p_Vf1 = 47; - Gpd_p_Vf1 has mM_per_minute; - Gpd_p_K1nadh = 0.023; - Gpd_p_K1nadh has mM; - Gpd_p_K1dhap = 0.54; - Gpd_p_K1dhap has mM; - Gpd_p_NADH = 1.87; - Gpd_p_NADH has mM; - Gpd_p_NAD = 1.45; - Gpd_p_NAD has mM; - Gpd_p_Keq1 = 10000; - Gpd_p_Keq1 has dimensionless; - Gpd_p_F16BP = 6.01; - Gpd_p_F16BP has mM; - Gpd_p_K1f16bp = 4.8; - Gpd_p_K1f16bp has mM; - Gpd_p_ATP = 2.37; - Gpd_p_ATP has mM; - Gpd_p_K1atp = 0.73; - Gpd_p_K1atp has mM; - Gpd_p_ADP = 2.17; - Gpd_p_ADP has mM; - Gpd_p_K1adp = 2; - Gpd_p_K1adp has mM; - Gpd_p_K1nad = 0.93; - Gpd_p_K1nad has mM; - Gpd_p_K1g3p = 1.2; - Gpd_p_K1g3p has mM; - Gpp_p_V2 = 53; - Gpp_p_V2 has mM_per_minute; - Gpp_p_K2g3p = 3.5; - Gpp_p_K2g3p has mM; - Gpp_p_Phi = 1; - Gpp_p_Phi has mM; - Gpp_p_K2phi = 1; - Gpp_p_K2phi has mM; - - // Other declarations: - const compartment_; - - // Unit definitions: - unit substance = 1e-3 mole; - unit time_unit = 60 second; - unit mM_per_minute = 1e-3 mole / (litre * 60 second); - unit mM = 1e-3 mole / litre; - - // Display Names: - substance is "millimole"; - time_unit is "minute"; - compartment_ is "Cytoplasm"; - G3P is "Glycerol 3-phosphate"; - Gly is "Glycerol"; - Gpd_p is "Glycerol 3-phosphate dehydrogenase"; - Gpp_p is "Glycerol 3-phosphatase"; - - // CV terms: - compartment_ identity "http://identifiers.org/obo.go/GO:0005737" - G3P identity "http://identifiers.org/obo.chebi/CHEBI:15978", - "http://identifiers.org/kegg.compound/C00093" - Gly identity "http://identifiers.org/obo.chebi/CHEBI:17754", - "http://identifiers.org/kegg.compound/C00116" - DHAP identity "http://identifiers.org/obo.chebi/CHEBI:16108", - "http://identifiers.org/kegg.compound/C00111" - Gpd_p identity "http://identifiers.org/ec-code/1.1.1.94", - "http://identifiers.org/kegg.reaction/R00842" - Gpp_p identity "http://identifiers.org/ec-code/3.1.3.21", - "http://identifiers.org/kegg.reaction/R00841" -end - -Cronwright2002_Glycerol_Synthesis is "Cronwright2002_Glycerol_Synthesis" - -Cronwright2002_Glycerol_Synthesis model_entity_is "http://identifiers.org/biomodels.db/MODEL6624139162" -Cronwright2002_Glycerol_Synthesis model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000076" -Cronwright2002_Glycerol_Synthesis description "http://identifiers.org/pubmed/12200299" -Cronwright2002_Glycerol_Synthesis identity "http://identifiers.org/obo.go/GO:0006114" -Cronwright2002_Glycerol_Synthesis parthood "http://identifiers.org/kegg.pathway/sce00561" -Cronwright2002_Glycerol_Synthesis taxon "http://identifiers.org/taxonomy/4932" diff --git a/BioModelsRAG/data/BIOMD0000000077.txt b/BioModelsRAG/data/BIOMD0000000077.txt deleted file mode 100644 index 496497d7d6c03be5e57b33bc55101e0b6bcc42f1..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000077.txt +++ /dev/null @@ -1,96 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Model_1() - - // Compartments and Species: - compartment cell; - species H in cell, HR in cell, R in cell, HRRH in cell, E in cell, GQ in cell; - species IP3 in cell, $CHO in cell; - - // Assignment Rules: - CHO := 0.001*alpha*IP3*(0.3 + 0.3*beta*time*exp(1 - beta*time))/(1 + 0.001*alpha*IP3); - - // Reactions: - reaction_0: H + R -> HR; cell*(reaction_0_k1*H*R - reaction_0_k2*HR); - reaction_1: 2 HR -> HRRH; cell*(reaction_1_k1*HR^2 - reaction_1_k2*HRRH); - reaction_2: HRRH + GQ -> E; cell*(reaction_2_k1*HRRH*GQ - reaction_2_k2*E); - reaction_3: IP3 => ; cell*reaction_3_k1*IP3; - reaction_4: => IP3; cell*reaction_4_k*E; - - // Events: - RemovalH: at time > 5: H = 0; - - // Species initializations: - H = 1; - HR = 0; - R = 0.01; - HRRH = 0; - E = 0; - GQ = 0.1; - IP3 = 0; - - // Compartment initializations: - cell = 1; - - // Variable initializations: - alpha = 2; - alpha has substance; - beta = 4; - beta has unitDefinition_3; - reaction_0_k1 = 2.5; - reaction_0_k2 = 5; - reaction_1_k1 = 2500; - reaction_1_k2 = 5; - reaction_2_k1 = 4000; - reaction_2_k2 = 200; - reaction_3_k1 = 10; - reaction_4_k = 20000000; - - // Other declarations: - const cell, alpha, beta; - - // Unit definitions: - unit time_unit = 60 second; - unit substance = 1e-9 mole; - unit unitDefinition_3 = 1 / 60 second; - - // Display Names: - unitDefinition_3 is "unit for beta"; - RemovalH is "removal of hormone"; - reaction_0 is "H binding to R"; - reaction_1 is "HR forming HRRH"; - reaction_2 is "G protein react with dimer producing E"; - reaction_3 is "IP3 converted into inactive metabolites"; - reaction_4 is "Production of IP3"; - - // CV terms: - cell identity "http://identifiers.org/go/GO:0005623" - H version "http://identifiers.org/uniprot/P51924" - H version "http://identifiers.org/uniprot/P07490" - HR version "http://identifiers.org/uniprot/P07490", - "http://identifiers.org/uniprot/P30969" - R version "http://identifiers.org/uniprot/P30969" - HRRH hypernym "http://identifiers.org/go/GO:0043234" - E identity "http://identifiers.org/pirsf/PIRSF005483" - GQ version "http://identifiers.org/go/GO:0005834" - IP3 hypernym "http://identifiers.org/chebi/CHEBI:16595" - IP3 hypernym "http://identifiers.org/kegg.compound/C01245" - CHO hypernym "http://identifiers.org/interpro/IPR000699" - reaction_0 hypernym "http://identifiers.org/go/GO:0051428", - "http://identifiers.org/go/GO:0005102" - reaction_0 hypernym "http://identifiers.org/go/GO:0004968" - reaction_1 hypernym "http://identifiers.org/go/GO:0006461" - reaction_2 hypernym "http://identifiers.org/go/GO:0007202" - reaction_3 hypernym "http://identifiers.org/go/GO:0009056" - reaction_4 hypernym "http://identifiers.org/go/GO:0004629" -end - -Model_1 is "Blum2000_LHsecretion_1" - -Model_1 model_entity_is "http://identifiers.org/biomodels.db/MODEL3092061764" -Model_1 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000077" -Model_1 description "http://identifiers.org/pubmed/10662710" -Model_1 parthood "http://identifiers.org/go/GO:0032275", - "http://identifiers.org/go/GO:0007200" -Model_1 taxon "http://identifiers.org/taxonomy/131567" -Model_1 hypernym "http://identifiers.org/go/GO:0097210" -Model_1 property "http://identifiers.org/mamo/MAMO_0000046" diff --git a/BioModelsRAG/data/BIOMD0000000078.txt b/BioModelsRAG/data/BIOMD0000000078.txt deleted file mode 100644 index 750ad3b07bbfdbe215a921d9018314111998313f..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000078.txt +++ /dev/null @@ -1,374 +0,0 @@ -// Created by libAntimony v2.13.0 -function function_3(Vs, B, n, K) - Vs*B^n/(K^n + B^n); -end - -function_3 is "Activation of gene" - -function function_2(V, substrate, Km) - V*substrate/(Km + substrate); -end - -function_2 is "Michaelis-Menten(irreversible)" - -function function_1(k, mRNA) - k*mRNA; -end - -function_1 is "mRNA translated into protein" - -function function_0(vsb, K, m, Bn) - vsb*K^m/(K^m + Bn^m); -end - -function_0 is "Inhibition of gene" - -function functionDefinition_0000005(length, time_ref) - ceil(sin(pi*time_ref/ length + 0.001)/2); -end - -functionDefinition_0000005 is "ceiling" - - -model *Model_1() - - // Compartments and Species: - compartment cell; - species species_0 in cell, species_1 in cell, species_2 in cell, species_3 in cell; - species species_4 in cell, species_5 in cell, species_6 in cell, species_7 in cell; - species species_8 in cell, species_9 in cell, species_10 in cell, species_11 in cell; - species species_12 in cell, species_13 in cell, species_14 in cell, species_15 in cell; - - // Assignment Rules: - parameter_0000081 := functionDefinition_0000005(12, time); - parameter_0000082 := 1.5 + (1.8 - 1.5)*parameter_0000081; - - // Reactions: - reaction_0: => species_0; cell*function_0(reaction_0_vsb, reaction_0_K, reaction_0_m, species_3); - reaction_1: => species_1; cell*function_1(reaction_1_k, species_0); - reaction_2: species_0 => ; cell*reaction_2_k1*species_0; - reaction_3: species_1 => species_2; cell*function_2(reaction_3_V, species_1, reaction_3_Km); - reaction_4: species_1 -> species_3; cell*(reaction_4_k1*species_1 - reaction_4_k2*species_3); - reaction_5: => species_4; cell*function_1(reaction_5_k, species_5); - reaction_6: species_5 => ; cell*reaction_6_k1*species_5; - reaction_7: species_4 => species_6; cell*function_2(reaction_7_V, species_4, reaction_7_Km); - reaction_8: species_6 => ; cell*function_2(reaction_8_V, species_6, reaction_8_Km); - reaction_9: => species_7; cell*function_3(parameter_0000082, species_3, reaction_9_n, reaction_9_K); - reaction_10: => species_8; cell*function_1(reaction_10_k, species_7); - reaction_11: species_9 => ; cell*function_2(reaction_11_V, species_9, reaction_11_Km); - reaction_12: species_8 => species_9; cell*function_2(reaction_12_V, species_8, reaction_12_Km); - reaction_13: species_4 + species_8 -> species_10; cell*(reaction_13_k1*species_4*species_8 - reaction_13_k2*species_10); - reaction_14: species_10 => species_11; cell*function_2(reaction_14_V, species_10, reaction_14_Km); - reaction_15: species_11 => ; cell*function_2(reaction_15_V, species_11, reaction_15_Km); - reaction_16: species_10 -> species_12; cell*(reaction_16_k1*species_10 - reaction_16_k2*species_12); - reaction_17: species_14 => ; cell*reaction_17_k1*species_14; - reaction_18: species_2 => ; cell*reaction_18_k1*species_2; - reaction_19: species_13 => ; cell*reaction_19_k1*species_13; - reaction_20: => species_5; cell*function_3(reaction_20_Vs, species_3, reaction_20_n, reaction_20_K); - reaction_21: species_12 => species_14; cell*function_2(reaction_21_V, species_12, reaction_21_Km); - reaction_22: species_7 => ; cell*reaction_22_k1*species_7; - reaction_23: species_12 + species_3 -> species_15; cell*(reaction_23_k1*species_12*species_3 - reaction_23_k2*species_15); - reaction_24: species_0 => ; cell*function_2(reaction_24_V, species_0, reaction_24_Km); - reaction_25: species_5 => ; cell*function_2(reaction_25_V, species_5, reaction_25_Km); - reaction_26: species_7 => ; cell*function_2(reaction_26_V, species_7, reaction_26_Km); - reaction_27: species_8 => ; cell*reaction_27_k1*species_8; - reaction_28: species_4 => ; cell*reaction_28_k1*species_4; - reaction_29: species_9 => ; cell*reaction_29_k1*species_9; - reaction_30: species_6 => ; cell*reaction_30_k1*species_6; - reaction_31: species_11 => ; cell*reaction_31_k1*species_11; - reaction_32: species_10 => ; cell*reaction_32_k1*species_10; - reaction_33: species_14 => ; cell*function_2(reaction_33_V, species_14, reaction_33_Km); - reaction_34: species_1 => ; cell*reaction_34_k1*species_1; - reaction_35: species_2 => ; cell*function_2(reaction_35_V, species_2, reaction_35_Km); - reaction_36: species_3 => species_13; cell*function_2(reaction_36_V, species_3, reaction_36_Km); - reaction_37: species_13 => ; cell*function_2(reaction_37_V, species_13, reaction_37_Km); - reaction_38: species_15 => ; cell*reaction_38_k1*species_15; - reaction_39: species_15 => ; cell*function_2(reaction_39_V, species_15, reaction_39_Km); - reaction_40: species_3 => ; cell*reaction_40_k1*species_3; - reaction_41: species_2 => species_1; cell*function_2(reaction_41_V, species_2, reaction_41_Km); - reaction_42: species_13 => species_3; cell*function_2(reaction_42_V, species_13, reaction_42_Km); - reaction_43: species_6 => species_4; cell*function_2(reaction_43_V, species_6, reaction_43_Km); - reaction_44: species_9 => species_8; cell*function_2(reaction_44_V, species_9, reaction_44_Km); - reaction_45: species_14 => species_12; cell*function_2(reaction_45_V, species_14, reaction_45_Km); - reaction_46: species_12 => ; cell*reaction_46_k1*species_12; - reaction_47: species_11 => species_10; cell*function_2(reaction_47_V, species_11, reaction_47_Km); - - // Species initializations: - species_0 = 9.5; - species_1 = 2; - species_2 = 0; - species_3 = 1.9; - species_4 = 0; - species_5 = 1.7; - species_6 = 0; - species_7 = 2.5; - species_8 = 0; - species_9 = 0; - species_10 = 0; - species_11 = 0; - species_12 = 1; - species_13 = 0; - species_14 = 0; - species_15 = 0; - - // Compartment initializations: - cell = 1; - - // Variable initializations: - reaction_0_vsb = 1; - reaction_0_K = 2.2; - reaction_0_m = 2; - reaction_1_k = 0.12; - reaction_2_k1 = 0.01; - reaction_3_V = 0.5; - reaction_3_Km = 0.1; - reaction_4_k1 = 0.4; - reaction_4_k2 = 0.2; - reaction_5_k = 1.6; - reaction_6_k1 = 0.01; - reaction_7_V = 0.6; - reaction_7_Km = 0.1; - reaction_8_V = 0.7; - reaction_8_Km = 0.3; - reaction_9_n = 4; - reaction_9_K = 0.7; - reaction_10_k = 0.6; - reaction_11_V = 0.7; - reaction_11_Km = 0.3; - reaction_12_V = 0.4; - reaction_12_Km = 0.1; - reaction_13_k1 = 0.4; - reaction_13_k2 = 0.2; - reaction_14_V = 0.4; - reaction_14_Km = 0.1; - reaction_15_V = 0.7; - reaction_15_Km = 0.3; - reaction_16_k1 = 0.4; - reaction_16_k2 = 0.2; - reaction_17_k1 = 0.01; - reaction_18_k1 = 0.01; - reaction_19_k1 = 0.01; - reaction_20_Vs = 1.1; - reaction_20_n = 4; - reaction_20_K = 0.6; - reaction_21_V = 0.4; - reaction_21_Km = 0.1; - reaction_22_k1 = 0.01; - reaction_23_k1 = 0.5; - reaction_23_k2 = 0.1; - reaction_24_V = 0.8; - reaction_24_Km = 0.4; - reaction_25_V = 1; - reaction_25_Km = 0.4; - reaction_26_V = 1.1; - reaction_26_Km = 0.31; - reaction_27_k1 = 0.01; - reaction_28_k1 = 0.12; - reaction_29_k1 = 0.01; - reaction_30_k1 = 0.01; - reaction_31_k1 = 0.01; - reaction_32_k1 = 0.01; - reaction_33_V = 0.7; - reaction_33_Km = 0.3; - reaction_34_k1 = 0.01; - reaction_35_V = 0.5; - reaction_35_Km = 0.3; - reaction_36_V = 0.5; - reaction_36_Km = 0.1; - reaction_37_V = 0.6; - reaction_37_Km = 0.3; - reaction_38_k1 = 0.01; - reaction_39_V = 0.8; - reaction_39_Km = 0.3; - reaction_40_k1 = 0.01; - reaction_41_V = 0.1; - reaction_41_Km = 0.1; - reaction_42_V = 0.2; - reaction_42_Km = 0.1; - reaction_43_V = 0.1; - reaction_43_Km = 0.1; - reaction_44_V = 0.3; - reaction_44_Km = 0.1; - reaction_45_V = 0.1; - reaction_45_Km = 0.1; - reaction_46_k1 = 0.01; - reaction_47_V = 0.1; - reaction_47_Km = 0.1; - - // Other declarations: - var parameter_0000081, parameter_0000082; - const cell; - - // Unit definitions: - unit time_unit = 3600 second; - unit substance = 1e-9 mole; - - // Display Names: - species_0 is "Mb"; - species_1 is "Bc"; - species_2 is "Bcp"; - species_3 is "Bn"; - species_4 is "Cc"; - species_5 is "Mc"; - species_6 is "Ccp"; - species_7 is "Mp"; - species_8 is "Pc"; - species_9 is "Pcp"; - species_10 is "PCc"; - species_11 is "PCcp"; - species_12 is "PCn"; - species_13 is "Bnp"; - species_14 is "PCnp"; - species_15 is "In"; - parameter_0000081 is "LD"; - parameter_0000082 is "vsp"; - reaction_0 is "Mb synthesized"; - reaction_1 is "Mb translated into protein"; - reaction_2 is "Mb nonspecific degradation"; - reaction_3 is "Bc phosphorylation"; - reaction_4 is "Bc transfered from cytosolic to nuclear"; - reaction_5 is "Mc translated into protein"; - reaction_6 is "Mc nonspecific degradation"; - reaction_7 is "Cc phosphorylation"; - reaction_8 is "Ccp specific degradation"; - reaction_9 is "Mp synthesis"; - reaction_10 is "Mp translated into protein"; - reaction_11 is "Pcp specific degradation"; - reaction_12 is "Pc phosphorylation"; - reaction_13 is "Cc and Pc produce complex Per_Cry"; - reaction_14 is "PCc phosphorylation"; - reaction_15 is "PCcp specific degradation"; - reaction_16 is "PCc transfered into nuclear"; - reaction_17 is "PCnp nonspecific degradation"; - reaction_18 is "Bcp nonspecific degradation"; - reaction_19 is "Bnp nonspecific degradation"; - reaction_20 is "Mc synthesis"; - reaction_21 is "PCn phosphorylation"; - reaction_22 is "Mp nonspecific degradation"; - reaction_23 is "Per_Cry and Clock_Bmal form inactive complex"; - reaction_24 is "Mb specific degradation"; - reaction_25 is "Mc specific degradation"; - reaction_26 is "Mp specific degradation"; - reaction_27 is "Pc nonspecific degradation"; - reaction_28 is "Cc nonspecific degradation"; - reaction_29 is "Pcp nonspecific degradation"; - reaction_30 is "Ccp nonspecific degradation"; - reaction_31 is "PCcp nonspecific degradation"; - reaction_32 is "PCc nonspecific degradation"; - reaction_33 is "PCnp specific degradation"; - reaction_34 is "Bc nonspecific degradation"; - reaction_35 is "Bcp specific degradation"; - reaction_36 is "Bn phosphorylation"; - reaction_37 is "Bnp specific degradation"; - reaction_38 is "In nonspecific degration"; - reaction_39 is "In specific degradation"; - reaction_40 is "Bn nonspecific degradation"; - reaction_41 is "Bcp dephosphorylation"; - reaction_42 is "Bnp dephosphorylation"; - reaction_43 is "Ccp dephosphorylation"; - reaction_44 is "Pcp dephosphorylation"; - reaction_45 is "PCnp dephosphorylation"; - reaction_46 is "PCn nonspecific degradation"; - reaction_47 is "PCcp dephosphorylation"; - - // CV terms: - cell hypernym "http://identifiers.org/obo.go/GO:0005623" - species_0 hypernym "http://identifiers.org/obo.chebi/CHEBI:33699" - species_1 version "http://identifiers.org/uniprot/O00327" - species_2 version "http://identifiers.org/uniprot/O00327" - species_3 version "http://identifiers.org/uniprot/O00327" - species_4 version "http://identifiers.org/uniprot/Q8IV71", - "http://identifiers.org/uniprot/Q16526" - species_5 parthood "http://identifiers.org/obo.chebi/CHEBI:33699" - species_6 version "http://identifiers.org/uniprot/Q8IV71", - "http://identifiers.org/uniprot/Q16526" - species_7 hypernym "http://identifiers.org/obo.chebi/CHEBI:33699" - species_8 version "http://identifiers.org/uniprot/P56645", - "http://identifiers.org/uniprot/O15055", - "http://identifiers.org/uniprot/O15534" - species_9 version "http://identifiers.org/uniprot/P56645", - "http://identifiers.org/uniprot/O15055", - "http://identifiers.org/uniprot/O15534" - species_10 part "http://identifiers.org/uniprot/P56645", - "http://identifiers.org/uniprot/Q8IV71" - species_10 part "http://identifiers.org/uniprot/O15534", - "http://identifiers.org/uniprot/Q8IV71" - species_10 part "http://identifiers.org/uniprot/O15534", - "http://identifiers.org/uniprot/Q16526" - species_11 part "http://identifiers.org/uniprot/P56645", - "http://identifiers.org/uniprot/Q8IV71" - species_11 part "http://identifiers.org/uniprot/O15534", - "http://identifiers.org/uniprot/Q16526" - species_12 part "http://identifiers.org/uniprot/P56645", - "http://identifiers.org/uniprot/Q8IV71" - species_12 part "http://identifiers.org/uniprot/O15534", - "http://identifiers.org/uniprot/Q8IV71" - species_12 part "http://identifiers.org/uniprot/O15534", - "http://identifiers.org/uniprot/Q16526" - species_13 hypernym "http://identifiers.org/uniprot/O00327" - species_14 part "http://identifiers.org/uniprot/P56645", - "http://identifiers.org/uniprot/Q8IV71" - species_14 part "http://identifiers.org/uniprot/O15055", - "http://identifiers.org/uniprot/Q8IV71" - species_14 part "http://identifiers.org/uniprot/O15534", - "http://identifiers.org/uniprot/Q16526" - reaction_0 hypernym "http://identifiers.org/obo.go/GO:0045892" - reaction_1 hypernym "http://identifiers.org/obo.go/GO:0006412" - reaction_2 hypernym "http://identifiers.org/obo.go/GO:0051261" - reaction_3 hypernym "http://identifiers.org/obo.go/GO:0006468" - reaction_4 hypernym "http://identifiers.org/obo.go/GO:0000060" - reaction_5 hypernym "http://identifiers.org/obo.go/GO:0006412" - reaction_6 hypernym "http://identifiers.org/obo.go/GO:0051261" - reaction_7 hypernym "http://identifiers.org/obo.go/GO:0006468" - reaction_8 hypernym "http://identifiers.org/obo.go/GO:0008233" - reaction_9 identity "http://identifiers.org/obo.go/GO:0045893" - reaction_10 hypernym "http://identifiers.org/obo.go/GO:0006412" - reaction_11 hypernym "http://identifiers.org/obo.go/GO:0008233" - reaction_12 hypernym "http://identifiers.org/obo.go/GO:0006468" - reaction_13 hypernym "http://identifiers.org/obo.go/GO:0043623" - reaction_14 hypernym "http://identifiers.org/obo.go/GO:0006468" - reaction_15 parthood "http://identifiers.org/obo.go/GO:0008233" - reaction_16 hypernym "http://identifiers.org/obo.go/GO:0000060" - reaction_17 hypernym "http://identifiers.org/obo.go/GO:0051261" - reaction_18 hypernym "http://identifiers.org/obo.go/GO:0051261" - reaction_19 hypernym "http://identifiers.org/obo.go/GO:0051261" - reaction_20 hypernym "http://identifiers.org/obo.go/GO:0045893" - reaction_21 hypernym "http://identifiers.org/obo.go/GO:0006468" - reaction_22 hypernym "http://identifiers.org/obo.go/GO:0051261" - reaction_23 hypernym "http://identifiers.org/obo.go/GO:0043623" - reaction_24 hypernym "http://identifiers.org/obo.go/GO:0008233" - reaction_25 hypernym "http://identifiers.org/obo.go/GO:0008233" - reaction_26 parthood "http://identifiers.org/obo.go/GO:0008233" - reaction_27 hypernym "http://identifiers.org/obo.go/GO:0051261" - reaction_28 hypernym "http://identifiers.org/obo.go/GO:0051261" - reaction_29 hypernym "http://identifiers.org/obo.go/GO:0051261" - reaction_30 hypernym "http://identifiers.org/obo.go/GO:0051261" - reaction_31 hypernym "http://identifiers.org/obo.go/GO:0051261" - reaction_32 hypernym "http://identifiers.org/obo.go/GO:0051261" - reaction_33 hypernym "http://identifiers.org/obo.go/GO:0008233" - reaction_34 hypernym "http://identifiers.org/obo.go/GO:0051261" - reaction_35 hypernym "http://identifiers.org/obo.go/GO:0008233" - reaction_36 hypernym "http://identifiers.org/obo.go/GO:0006468" - reaction_37 hypernym "http://identifiers.org/obo.go/GO:0008233" - reaction_38 hypernym "http://identifiers.org/obo.go/GO:0051261" - reaction_39 hypernym "http://identifiers.org/obo.go/GO:0008233" - reaction_40 parthood "http://identifiers.org/obo.go/GO:0051261" - reaction_41 hypernym "http://identifiers.org/obo.go/GO:0006470" - reaction_42 hypernym "http://identifiers.org/obo.go/GO:0006470" - reaction_43 hypernym "http://identifiers.org/obo.go/GO:0006470" - reaction_44 hypernym "http://identifiers.org/obo.go/GO:0006470" - reaction_45 hypernym "http://identifiers.org/obo.go/GO:0006470" - reaction_46 version "http://identifiers.org/obo.go/GO:0051261" - reaction_47 hypernym "http://identifiers.org/obo.go/GO:0006470", - "http://identifiers.org/obo.go/GO:0016311" -end - -Model_1 is "Leloup2003_CircClock_LD" - -Model_1 model_entity_is "http://identifiers.org/biomodels.db/MODEL4108701438" -Model_1 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000078" -Model_1 description "http://identifiers.org/pubmed/12775757" -Model_1 origin "http://identifiers.org/biomodels.db/BIOMD0000000021" -Model_1 taxon "http://identifiers.org/taxonomy/40674" -Model_1 hypernym "http://identifiers.org/obo.go/GO:0009649" -Model_1 version "http://identifiers.org/kegg.pathway/hsa04710" diff --git a/BioModelsRAG/data/BIOMD0000000079.txt b/BioModelsRAG/data/BIOMD0000000079.txt deleted file mode 100644 index ca5b2d9e2e57dec1e1fa2cf02f6481e2f63a4ade..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000079.txt +++ /dev/null @@ -1,91 +0,0 @@ -// Created by libAntimony v2.13.0 -function function_4(P, V3, R, k3) - P*V3*(1 - R)/(k3 + (1 - R)); -end - -function function_3(V2, R, Q, K2) - V2*R*Q/(K2 + Q); -end - -function function_2(V1, Q, K1) - V1*(1 - Q)/(K1 + (1 - Q)); -end - -function function_1(V, substrate, Km) - V*substrate/(Km + substrate); -end - -function function_0(a, Q) - a*Q; -end - - -model *Model_0() - - // Compartments and Species: - compartment body; - substanceOnly species P in body, Q in body, R in body; - - // Reactions: - reaction_0: => P; body*function_0(reaction_0_a, Q); - reaction_1: P => ; function_1(reaction_1_V, P, reaction_1_Km); - reaction_2: => Q; function_2(reaction_2_V1, Q, reaction_2_K1); - reaction_3: Q => ; function_3(reaction_3_V2, R, Q, reaction_3_K2); - reaction_4: => R; function_4(P, reaction_4_V3, R, reaction_4_k3); - reaction_5: R => ; function_1(reaction_5_V, R, reaction_5_Km); - - // Species initializations: - P = 0.43; - Q = 0.8; - R = 0.55; - - // Compartment initializations: - body = 1; - - // Variable initializations: - reaction_0_a = 0.1; - reaction_1_V = 0.1; - reaction_1_Km = 0.2; - reaction_2_V1 = 1; - reaction_2_K1 = 0.01; - reaction_3_V2 = 1.5; - reaction_3_K2 = 0.01; - reaction_4_V3 = 6; - reaction_4_k3 = 0.01; - reaction_5_V = 2.5; - reaction_5_Km = 0.01; - - // Other declarations: - const body; - - // Unit definitions: - unit time_unit = 604800 second; - unit substance = dimensionless; - - // Display Names: - time_unit is "weeks"; - substance is "dimensionless"; - reaction_0 is "Increase of P"; - reaction_1 is "Decrease of P"; - reaction_2 is "Increase of Q"; - reaction_3 is "Decrease of Q"; - reaction_4 is "Increase of R"; - reaction_5 is "Decrease of R"; - - // CV terms: - reaction_0 hypernym "http://identifiers.org/go/GO:0040018", - "http://identifiers.org/go/GO:0035264" - reaction_1 hypernym "http://identifiers.org/go/GO:0040015" - reaction_2 hypernym "http://identifiers.org/go/GO:0007631" - reaction_3 hypernym "http://identifiers.org/go/GO:0002023" - reaction_4 hypernym "http://identifiers.org/go/GO:0048520" - reaction_5 hypernym "http://identifiers.org/go/GO:0048521" -end - -Model_0 is "Goldbeter2006_weightCycling" - -Model_0 model_entity_is "http://identifiers.org/biomodels.db/MODEL4644593552" -Model_0 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000079" -Model_0 description "http://identifiers.org/pubmed/16595882" -Model_0 taxon "http://identifiers.org/taxonomy/9606" -Model_0 hypernym "http://identifiers.org/go/GO:0040014" diff --git a/BioModelsRAG/data/BIOMD0000000080.txt b/BioModelsRAG/data/BIOMD0000000080.txt deleted file mode 100644 index 13e775ef0953016700a1caaa339dca9055cf9da9..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000080.txt +++ /dev/null @@ -1,123 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Model_1() - - // Compartments and Species: - compartment cell; - species D in cell, DR in cell, DRG_GDP in cell, G_GDP in cell, DRG in cell; - species GDP in cell, DRG_GTP in cell, GTP in cell, G_GTP in cell, R in cell; - - // Reactions: - Reaction_1: D + R -> DR; cell*(Reaction_1_k1*D*R - Reaction_1_k7*DR); - Reaction_2: DR + G_GDP -> DRG_GDP; cell*(Reaction_2_k2*DR*G_GDP - Reaction_2_k8*DRG_GDP); - Reaction_3: DRG_GDP -> GDP + DRG; cell*(Reaction_3_k3*DRG_GDP - Reaction_3_k9*GDP*DRG); - Reaction_4: DRG + GTP -> DRG_GTP; cell*(Reaction_4_k4*DRG*GTP - Reaction_4_k10*DRG_GTP); - Reaction_5: DRG_GTP => G_GTP + DR; cell*Reaction_5_k5*DRG_GTP; - Reaction_6: G_GTP => G_GDP; cell*Reaction_6_k6*G_GTP; - - // Species initializations: - D = 3.1e-05; - DR = 0; - DRG_GDP = 0; - G_GDP = 1e-06; - DRG = 0; - GDP = 0; - DRG_GTP = 0; - GTP = 1e-05; - G_GTP = 0; - R = 1e-10; - - // Compartment initializations: - cell = 1; - - // Variable initializations: - Reaction_1_k1 = 5000000; - Reaction_1_k7 = 10; - Reaction_2_k2 = 100000000; - Reaction_2_k8 = 0.1; - Reaction_3_k3 = 5; - Reaction_3_k9 = 100000; - Reaction_4_k4 = 5000000; - Reaction_4_k10 = 55; - Reaction_5_k5 = 1; - Reaction_6_k6 = 2; - - // Other declarations: - const cell; - - // Display Names: - Reaction_1 is "Forming DR"; - Reaction_2 is "DR Binding with G_GDP produce DRG_GDP"; - Reaction_3 is "GDP Releasing"; - Reaction_4 is "GTP binding with DRG"; - Reaction_5 is "G protein activation"; - Reaction_6 is "Hydrolysis of GTP to GDP"; - - // CV terms: - cell hypernym "http://identifiers.org/go/GO:0005623" - D identity "http://identifiers.org/chebi/CHEBI:35569" - DR part "http://identifiers.org/chebi/CHEBI:35569", - "http://identifiers.org/uniprot/P08913" - DR part "http://identifiers.org/chebi/CHEBI:35569", - "http://identifiers.org/uniprot/P18089" - DR part "http://identifiers.org/chebi/CHEBI:35569", - "http://identifiers.org/uniprot/P18825" - DRG_GDP part "http://identifiers.org/chebi/CHEBI:35569", - "http://identifiers.org/chebi/CHEBI:17552", - "http://identifiers.org/uniprot/P08913", - "http://identifiers.org/go/GO:0005834" - DRG_GDP part "http://identifiers.org/chebi/CHEBI:35569", - "http://identifiers.org/chebi/CHEBI:17552", - "http://identifiers.org/uniprot/P18089", - "http://identifiers.org/go/GO:0005834" - DRG_GDP part "http://identifiers.org/chebi/CHEBI:35569", - "http://identifiers.org/chebi/CHEBI:17552", - "http://identifiers.org/uniprot/P18825", - "http://identifiers.org/go/GO:0005834" - G_GDP part "http://identifiers.org/chebi/CHEBI:17552", - "http://identifiers.org/go/GO:0005834" - DRG part "http://identifiers.org/chebi/CHEBI:35569", - "http://identifiers.org/uniprot/P08913", - "http://identifiers.org/go/GO:0005834" - DRG part "http://identifiers.org/chebi/CHEBI:35569", - "http://identifiers.org/uniprot/P18089", - "http://identifiers.org/go/GO:0005834" - DRG part "http://identifiers.org/chebi/CHEBI:35569", - "http://identifiers.org/uniprot/P18825", - "http://identifiers.org/go/GO:0005834" - GDP identity "http://identifiers.org/chebi/CHEBI:17552" - DRG_GTP part "http://identifiers.org/chebi/CHEBI:35569", - "http://identifiers.org/chebi/CHEBI:15996", - "http://identifiers.org/uniprot/P08913", - "http://identifiers.org/go/GO:0005834" - DRG_GTP part "http://identifiers.org/chebi/CHEBI:35569", - "http://identifiers.org/chebi/CHEBI:15996", - "http://identifiers.org/uniprot/P18089", - "http://identifiers.org/go/GO:0005834" - DRG_GTP part "http://identifiers.org/chebi/CHEBI:35569", - "http://identifiers.org/chebi/CHEBI:15996", - "http://identifiers.org/uniprot/P18825", - "http://identifiers.org/go/GO:0005834" - GTP identity "http://identifiers.org/chebi/CHEBI:15996" - G_GTP part "http://identifiers.org/chebi/CHEBI:15996", - "http://identifiers.org/go/GO:0005834" - R version "http://identifiers.org/uniprot/P08913", - "http://identifiers.org/uniprot/P18089", - "http://identifiers.org/uniprot/P18825" - Reaction_1 hypernym "http://identifiers.org/go/GO:0031690" - Reaction_2 hypernym "http://identifiers.org/go/GO:0001664" - Reaction_3 hypernym "http://identifiers.org/go/GO:0043241" - Reaction_4 hypernym "http://identifiers.org/go/GO:0005525", - "http://identifiers.org/go/GO:0032403" - Reaction_5 hypernym "http://identifiers.org/go/GO:0043241" - Reaction_6 hypernym "http://identifiers.org/go/GO:0003924" -end - -Model_1 is "Thomsen1989_AdenylateCyclase" - -Model_1 model_entity_is "http://identifiers.org/biomodels.db/MODEL1173806337" -Model_1 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000080" -Model_1 description "http://identifiers.org/pubmed/2574993" -Model_1 origin "http://identifiers.org/biomodels.db/BIOMD0000000082" -Model_1 hypernym "http://identifiers.org/go/GO:0031684", - "http://identifiers.org/go/GO:0007194" -Model_1 taxon "http://identifiers.org/taxonomy/9606" diff --git a/BioModelsRAG/data/BIOMD0000000081.txt b/BioModelsRAG/data/BIOMD0000000081.txt deleted file mode 100644 index fa07279649acb166698857fe720ea1814f5a4d5e..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000081.txt +++ /dev/null @@ -1,373 +0,0 @@ -// Created by libAntimony v2.13.0 -function Function_for_PIP2_5Pase(MgSat20, PIP2_M, kPIP2Pase) - MgSat20*kPIP2Pase*PIP2_M; -end - -Function_for_PIP2_5Pase is "Function for PIP2_5Pase" - -function Function_for_MgonGDPAIF4(GGDPAlF4_M, M, Mg2_C, kMgonAlF4) - kMgonAlF4*GGDPAlF4_M*Mg2_C*M; -end - -Function_for_MgonGDPAIF4 is "Function for MgonGDPAIF4" - -function Function_for_MgGTPon(GGTP_M, M, Mg2_C, kMg2onGTP) - kMg2onGTP*GGTP_M*Mg2_C*M; -end - -Function_for_MgGTPon is "Function for MgGTPon" - -function Function_for_PI4Kinase(ATPSat1000, M, MgSat20, PI_M, kPI4Kinase) - (0.2 + 0.8*MgSat20)*kPI4Kinase*PI_M*ATPSat1000*M; -end - -Function_for_PI4Kinase is "Function for PI4Kinase" - -function Function_for_PIP2binding(KCNQsites_M, PIP2_M, PIP2xKCNQ_M, kPIP2off, kPIP2on) - kPIP2on*KCNQsites_M*PIP2_M + -(kPIP2off*PIP2xKCNQ_M); -end - -Function_for_PIP2binding is "Function for PIP2binding" - -function Function_for_IP3Phosphatase(NA_micro, ip3_C, kIP3ase) - ip3_C*kIP3ase*NA_micro; -end - -Function_for_IP3Phosphatase is "Function for IP3Phosphatase" - -function Function_for_PLC(M, PIP2_M, PLCspont, fGactive, kPLC) - kPLC*(fGactive + PLCspont)*PIP2_M*M; -end - -Function_for_PLC is "Function for PLC" - -function Function_for_AIF4on(AlF4_C, GGDPAlF4_M, GGDP_M, M, kAlF4off, kAlF4on) - (kAlF4on*AlF4_C*GGDP_M + -(kAlF4off*GGDPAlF4_M))*M; -end - -Function_for_AIF4on is "Function for AIF4on" - -function Function_for_GGTPase(GGTPMg_M, MgSat10, kGGTPase) - kGGTPase*MgSat10*GGTPMg_M; -end - -Function_for_GGTPase is "Function for GGTPase" - -function Function_for_PIP5kinase(ATPSat300, MgSat20, PIP_M, kPIP5Kinase) - (0.2 + 0.8*MgSat20)*kPIP5Kinase*PIP_M*ATPSat300; -end - -Function_for_PIP5kinase is "Function for PIP5kinase" - -function Function_for_GDPdissoc(GDP_C, GGDP_M, G_M, M, OxoSat, TonicAct, kGDPoff, kGDPon) - (kGDPoff*GGDP_M*(OxoSat + TonicAct) + -(kGDPon*GDP_C*G_M))*M; -end - -Function_for_GDPdissoc is "Function for GDPdissoc" - -function Function_for_GTPon(GGTP_M, GTP_C, G_M, M, kGTPoff, kGTPon) - (kGTPon*G_M*GTP_C + -(kGTPoff*GGTP_M))*M; -end - -Function_for_GTPon is "Function for GTPon" - -function Function_for_GTPgSon(GGTPgS_M, GTPgS_C, G_M, M, kGTPgSoff, kGTPgSon) - (kGTPgSon*G_M*GTPgS_C + -(kGTPgSoff*GGTPgS_M))*M; -end - -Function_for_GTPgSon is "Function for GTPgSon" - -function Function_for_GDPbSon(GDPbS_C, GGDPbS_M, G_M, M, OxoSat, kGDPbSon, kGGDPbSoff) - (kGDPbSon*G_M*GDPbS_C + -(kGGDPbSoff*(1 + 20*OxoSat)*GGDPbS_M))*M; -end - -Function_for_GDPbSon is "Function for GDPbSon" - -function Function_for_MgonGGTPgS(GGTPgS_M, M, Mg2_C, kMg2onGTPgS) - kMg2onGTPgS*GGTPgS_M*Mg2_C*M; -end - -Function_for_MgonGGTPgS is "Function for MgonGGTPgS" - - -model *Suh2004_KCNQ_regulation() - - // Compartments and Species: - compartment EX, M, Cytoplasm; - species GTPgS_C in Cytoplasm, KCNQsites_M in M, PIP2_M in M, GGDPbS_M in M; - species $Mg2_C in Cytoplasm, ATP_C in Cytoplasm, oxoM_EX in EX, GDPbS_C in Cytoplasm; - species GGTPMg_M in M, GDP_C in Cytoplasm, $GTP_C in Cytoplasm, GGDPAlF4Mg_M in M; - species ip3_C in Cytoplasm, AlF4_C in Cytoplasm, G_M in M, GGTP_M in M; - species GGDPAlF4_M in M, GGTPgS_M in M, PI_M in M, PIP_M in M, PIP2xKCNQ_M in M; - species GGTPgSMg_M in M, GGDP_M in M; - - // Assignment Rules: - GTP_C := 100 - 50*exp(-(0.00833333333333333*(290 + time))); - MgSat20 := 1*(1/(1 + 20*(1/Mg2_C))); - ATPSat300 := 1*(1/(1 + 300*(1/(0.5 + ATP_C)))); - MgSat10 := 0.2 + 0.8*1*(1/(1 + KMgGTPase*(1/Mg2_C))); - OxoSat := 1*(1/(1 + Koxom*(1/(1e-5 + oxoM_EX)))); - Gactive := GGTPMg_M + GGTPgSMg_M + GGDPAlF4Mg_M; - ATPSat1000 := 1*(1/(1 + 1000*(1/(0.5 + ATP_C)))); - I_KCNQ := 1.33*(0.025*PIP2xKCNQ_M)^nHill; - fGactive := (GGTPMg_M + GGTPgSMg_M + GGDPAlF4Mg_M)/200; - - // Reactions: - PIP5kinase: 0.0009967 ATP_C + PIP_M -> PIP2_M; Function_for_PIP5kinase(ATPSat300, MgSat20, PIP_M, PIP5kinase_kPIP5Kinase); - IP3Phosphatase: 1.66611e-18 ip3_C -> ; Cytoplasm*Function_for_IP3Phosphatase(NA_micro, ip3_C, IP3Phosphatase_kIP3ase); - PIP2binding: KCNQsites_M + PIP2_M -> PIP2xKCNQ_M; M*Function_for_PIP2binding(KCNQsites_M, PIP2_M, PIP2xKCNQ_M, PIP2binding_kPIP2off, PIP2binding_kPIP2on); - MgonGGTPgS: GGTPgS_M -> GGTPgSMg_M; Function_for_MgonGGTPgS(GGTPgS_M, M, Mg2_C, MgonGGTPgS_kMg2onGTPgS); - GGTPase: GGTPMg_M -> GGDP_M; M*Function_for_GGTPase(GGTPMg_M, MgSat10, GGTPase_kGGTPase); - GTPon: G_M -> GGTP_M; Function_for_GTPon(GGTP_M, GTP_C, G_M, M, GTPon_kGTPoff, GTPon_kGTPon); - GTPgSon: 0.0009967 GTPgS_C + G_M -> GGTPgS_M; Function_for_GTPgSon(GGTPgS_M, GTPgS_C, G_M, M, GTPgSon_kGTPgSoff, GTPgSon_kGTPgSon); - GDPbSon: G_M + 0.0009967 GDPbS_C -> GGDPbS_M; Function_for_GDPbSon(GDPbS_C, GGDPbS_M, G_M, M, OxoSat, GDPbSon_kGDPbSon, GDPbSon_kGGDPbSoff); - MgGTPon: GGTP_M -> GGTPMg_M; Function_for_MgGTPon(GGTP_M, M, Mg2_C, MgGTPon_kMg2onGTP); - GDPdissoc: GGDP_M -> 0.0009967 GDP_C + G_M; Function_for_GDPdissoc(GDP_C, GGDP_M, G_M, M, OxoSat, GDPdissoc_TonicAct, GDPdissoc_kGDPoff, GDPdissoc_kGDPon); - PIP2_5Pase: PIP2_M -> PIP_M; M*Function_for_PIP2_5Pase(MgSat20, PIP2_M, PIP2_5Pase_kPIP2Pase); - PLC: PIP2_M -> 0.0009967 ip3_C; Function_for_PLC(M, PIP2_M, PLC_PLCspont, fGactive, PLC_kPLC); - AlF4on: 0.0009967 AlF4_C + GGDP_M -> GGDPAlF4_M; Function_for_AIF4on(AlF4_C, GGDPAlF4_M, GGDP_M, M, AlF4on_kAlF4off, AlF4on_kAlF4on); - PI4Kinase: 0.0009967 ATP_C + PI_M -> PIP_M; Function_for_PI4Kinase(ATPSat1000, M, MgSat20, PI_M, PI4Kinase_kPI4Kinase); - MgonGDPAlF4: GGDPAlF4_M -> GGDPAlF4Mg_M; Function_for_MgonGDPAIF4(GGDPAlF4_M, M, Mg2_C, MgonGDPAlF4_kMgonAlF4); - - // Events: - event_0000001_0: at 0 after time >= 3: oxoM_EX = 10; - event_0000002_0: at 0 after time >= 8: oxoM_EX = 0; - - // Species initializations: - GTPgS_C = 0; - GTPgS_C has substance_per_volume; - KCNQsites_M = 6.7; - KCNQsites_M has substance_per_volume; - PIP2_M = 5000; - PIP2_M has substance_per_volume; - GGDPbS_M = 0; - GGDPbS_M has substance_per_volume; - Mg2_C = 2100; - Mg2_C has substance_per_volume; - ATP_C = 3000; - ATP_C has substance_per_volume; - oxoM_EX = 0; - oxoM_EX has substance_per_volume; - GDPbS_C = 0; - GDPbS_C has substance_per_volume; - GGTPMg_M = 0.1; - GGTPMg_M has substance_per_volume; - GDP_C = 0; - GDP_C has substance_per_volume; - GTP_C has substance_per_volume; - GGDPAlF4Mg_M = 0; - GGDPAlF4Mg_M has substance_per_volume; - ip3_C = 0.48; - ip3_C has substance_per_volume; - AlF4_C = 0; - AlF4_C has substance_per_volume; - G_M = 0.065; - G_M has substance_per_volume; - GGTP_M = 0.048; - GGTP_M has substance_per_volume; - GGDPAlF4_M = 0; - GGDPAlF4_M has substance_per_volume; - GGTPgS_M = 0; - GGTPgS_M has substance_per_volume; - PI_M = 200000; - PI_M has substance_per_volume; - PIP_M = 1150; - PIP_M has substance_per_volume; - PIP2xKCNQ_M = 33.3; - PIP2xKCNQ_M has substance_per_volume; - GGTPgSMg_M = 0; - GGTPgSMg_M has substance_per_volume; - GGDP_M = 200; - GGDP_M has substance_per_volume; - - // Compartment initializations: - EX = 1; - EX has volume; - M = 1; - M has volume; - Cytoplasm = 1; - Cytoplasm has volume; - MgSat20 has unit_0; - ATPSat300 has unit_0; - MgSat10 has unit_0; - - // Variable initializations: - KMgGTPase = 10; - KMgGTPase has unit_2; - OxoSat has unit_0; - Koxom = 8; - Koxom has unit_2; - Gactive has unit_1; - ATPSat1000 has unit_0; - I_KCNQ has unit_0; - nHill = 1.8; - nHill has unit_0; - fGactive has unit_0; - NA_micro = 6.022e+17; - NA_micro has unit_3; - PIP5kinase_kPIP5Kinase = 0.06; - IP3Phosphatase_kIP3ase = 0.3; - PIP2binding_kPIP2off = 0.25; - PIP2binding_kPIP2on = 0.00025; - MgonGGTPgS_kMg2onGTPgS = 0.002; - GGTPase_kGGTPase = 1.8; - GTPon_kGTPoff = 0.08; - GTPon_kGTPon = 0.45; - GTPgSon_kGTPgSoff = 0.005; - GTPgSon_kGTPgSon = 0.006; - GDPbSon_kGDPbSon = 0.28; - GDPbSon_kGGDPbSoff = 0.1; - MgGTPon_kMg2onGTP = 0.003; - GDPdissoc_TonicAct = 0.002; - GDPdissoc_kGDPoff = 0.5; - GDPdissoc_kGDPon = 0.003; - PIP2_5Pase_kPIP2Pase = 0.005; - PLC_PLCspont = 0.00075; - PLC_kPLC = 4.8; - AlF4on_kAlF4off = 0.005; - AlF4on_kAlF4on = 7e-06; - PI4Kinase_kPI4Kinase = 0.0001; - MgonGDPAlF4_kMgonAlF4 = 0.002; - - // Other declarations: - var MgSat20, ATPSat300, MgSat10, OxoSat, Gactive, ATPSat1000, I_KCNQ, fGactive; - const EX, M, Cytoplasm, KMgGTPase, Koxom, nHill, NA_micro; - - // Unit definitions: - unit length = metre; - unit area = (1e-6 metre)^2; - unit volume = litre; - unit time_unit = time_unit; - unit substance = item; - unit unit_0 = 1 / dimensionless^-0; - unit unit_1 = item / (1e6 metre)^2; - unit unit_2 = item * avogadro / ((1e-6 dimensionless)^-0 * litre); - unit unit_3 = 1 / 1e6 avogadro; - unit extent = substance; - unit substance_per_volume = item / litre; - - // Display Names: - time_unit is "time"; - unit_0 is "1"; - unit_1 is "#/Mm²"; - unit_2 is "µmol/l"; - unit_3 is "1/MAvogadro"; - EX is "Extracellular"; - M is "Membrane"; - GGDPAlF4Mg_M is "GGDPAIF4Mg_M"; - ip3_C is "IP3_C"; - AlF4_C is "AIF4_C"; - GGDPAlF4_M is "GGDPAIF4_M"; - event_0000001_0 is "event_0000001"; - event_0000002_0 is "event_0000002"; - NA_micro is "NA(micro)"; - AlF4on is "AIF4on"; - MgonGDPAlF4 is "MgonGDPAIF4"; - - // CV terms: - EX identity "http://identifiers.org/go/GO:0005576" - M identity "http://identifiers.org/go/GO:0005886" - Cytoplasm identity "http://identifiers.org/go/GO:0005737" - GTPgS_C identity "http://identifiers.org/kegg.compound/C01806" - GTPgS_C identity "http://identifiers.org/chebi/CHEBI:5235" - KCNQsites_M part "http://identifiers.org/uniprot/O88944" - KCNQsites_M part "http://identifiers.org/uniprot/O43526" - PIP2_M identity "http://identifiers.org/chebi/CHEBI:18348" - PIP2_M identity "http://identifiers.org/kegg.compound/C04637" - GGDPbS_M part "http://identifiers.org/chebi/CHEBI:38309" - GGDPbS_M part "http://identifiers.org/go/GO:0005834" - Mg2_C identity "http://identifiers.org/chebi/CHEBI:25107" - Mg2_C identity "http://identifiers.org/kegg.compound/C00305" - ATP_C identity "http://identifiers.org/kegg.compound/C00002" - ATP_C identity "http://identifiers.org/chebi/CHEBI:15422" - oxoM_EX identity "http://identifiers.org/chebi/CHEBI:38322" - GDPbS_C hypernym "http://identifiers.org/chebi/CHEBI:38309" - GGTPMg_M part "http://identifiers.org/kegg.compound/C00044" - GGTPMg_M part "http://identifiers.org/kegg.compound/C00305" - GGTPMg_M part "http://identifiers.org/go/GO:0005834" - GGTPMg_M part "http://identifiers.org/chebi/CHEBI:18420" - GGTPMg_M part "http://identifiers.org/chebi/CHEBI:15996" - GGTPMg_M part "http://identifiers.org/chebi/CHEBI:25107" - GDP_C identity "http://identifiers.org/kegg.compound/C00035" - GDP_C identity "http://identifiers.org/chebi/CHEBI:17552" - GTP_C identity "http://identifiers.org/chebi/CHEBI:15996" - GTP_C identity "http://identifiers.org/kegg.compound/C00044" - GGDPAlF4Mg_M part "http://identifiers.org/uniprot/P29992" - GGDPAlF4Mg_M part "http://identifiers.org/kegg.compound/C00305" - GGDPAlF4Mg_M part "http://identifiers.org/kegg.compound/C00035" - GGDPAlF4Mg_M part "http://identifiers.org/chebi/CHEBI:30111" - GGDPAlF4Mg_M part "http://identifiers.org/chebi/CHEBI:25107" - GGDPAlF4Mg_M part "http://identifiers.org/chebi/CHEBI:17552" - ip3_C identity "http://identifiers.org/chebi/CHEBI:16595" - ip3_C identity "http://identifiers.org/kegg.compound/C01245" - AlF4_C identity "http://identifiers.org/chebi/CHEBI:30111" - G_M identity "http://identifiers.org/go/GO:0005834" - GGTP_M part "http://identifiers.org/go/GO:0005834" - GGTP_M part "http://identifiers.org/chebi/CHEBI:15996" - GGTP_M part "http://identifiers.org/kegg.compound/C00044" - GGDPAlF4_M part "http://identifiers.org/kegg.compound/C00035" - GGDPAlF4_M part "http://identifiers.org/go/GO:0005834" - GGDPAlF4_M part "http://identifiers.org/chebi/CHEBI:17552" - GGDPAlF4_M part "http://identifiers.org/chebi/CHEBI:30111" - GGTPgS_M part "http://identifiers.org/go/GO:0005834" - GGTPgS_M part "http://identifiers.org/chebi/CHEBI:43000" - GGTPgS_M part "http://identifiers.org/chebi/CHEBI:5235" - GGTPgS_M part "http://identifiers.org/kegg.compound/C01806" - PI_M identity "http://identifiers.org/chebi/CHEBI:16749" - PI_M identity "http://identifiers.org/kegg.compound/C01194" - PIP_M identity "http://identifiers.org/chebi/CHEBI:17526" - PIP_M identity "http://identifiers.org/kegg.compound/C01277" - PIP2xKCNQ_M part "http://identifiers.org/uniprot/O88944" - PIP2xKCNQ_M part "http://identifiers.org/chebi/CHEBI:18348" - PIP2xKCNQ_M part "http://identifiers.org/kegg.compound/C04637" - PIP2xKCNQ_M part "http://identifiers.org/uniprot/O43526" - GGTPgSMg_M part "http://identifiers.org/kegg.compound/C00305" - GGTPgSMg_M part "http://identifiers.org/chebi/CHEBI:5235" - GGTPgSMg_M part "http://identifiers.org/chebi/CHEBI:25107" - GGTPgSMg_M part "http://identifiers.org/kegg.compound/C01806" - GGTPgSMg_M part "http://identifiers.org/go/GO:0005834" - GGTPgSMg_M part "http://identifiers.org/chebi/CHEBI:18420" - GGDP_M part "http://identifiers.org/go/GO:0005834" - GGDP_M part "http://identifiers.org/chebi/CHEBI:17552" - GGDP_M part "http://identifiers.org/kegg.compound/C00035" - PIP5kinase identity "http://identifiers.org/kegg.reaction/R03469" - PIP5kinase hypernym "http://identifiers.org/ec-code/2.7.1.68" - PIP5kinase hypernym "http://identifiers.org/go/GO:0016308" - IP3Phosphatase identity "http://identifiers.org/kegg.reaction/R03394" - IP3Phosphatase hypernym "http://identifiers.org/ec-code/3.1.3.56" - IP3Phosphatase hypernym "http://identifiers.org/go/GO:0004445" - PIP2binding hypernym "http://identifiers.org/go/GO:0005267" - PIP2binding hypernym "http://identifiers.org/go/GO:0005546" - MgonGGTPgS parthood "http://identifiers.org/go/GO:0031684" - GGTPase hypernym "http://identifiers.org/go/GO:0003924" - GTPon parthood "http://identifiers.org/go/GO:0031684" - GTPgSon parthood "http://identifiers.org/go/GO:0031684" - GDPbSon parthood "http://identifiers.org/go/GO:0031684" - MgGTPon parthood "http://identifiers.org/go/GO:0031684" - GDPdissoc parthood "http://identifiers.org/go/GO:0031684" - PIP2_5Pase identity "http://identifiers.org/kegg.reaction/R04404" - PIP2_5Pase hypernym "http://identifiers.org/ec-code/3.1.3.36" - PIP2_5Pase hypernym "http://identifiers.org/go/GO:0004439" - PLC identity "http://identifiers.org/kegg.reaction/R03435" - PLC hypernym "http://identifiers.org/ec-code/3.1.4.11" - PLC hypernym "http://identifiers.org/go/GO:0004435" - PLC hypernym "http://identifiers.org/go/GO:0007200" - AlF4on parthood "http://identifiers.org/go/GO:0031684" - PI4Kinase identity "http://identifiers.org/kegg.reaction/R03361" - PI4Kinase hypernym "http://identifiers.org/ec-code/2.7.1.67" - PI4Kinase hypernym "http://identifiers.org/go/GO:0004430" - MgonGDPAlF4 parthood "http://identifiers.org/go/GO:0031684" -end - -Suh2004_KCNQ_regulation is "Suh2004_KCNQ_Regulation" - -Suh2004_KCNQ_regulation model_entity_is "http://identifiers.org/biomodels.db/MODEL4662889298", - "http://identifiers.org/biomodels.db/BIOMD0000000081" -Suh2004_KCNQ_regulation part "http://identifiers.org/go/GO:0007207" -Suh2004_KCNQ_regulation part "http://identifiers.org/go/GO:0006629" -Suh2004_KCNQ_regulation identity "http://identifiers.org/biomodels.db/MODEL4662889298" -Suh2004_KCNQ_regulation identity "http://identifiers.org/kegg.pathway/map04020" -Suh2004_KCNQ_regulation identity "http://identifiers.org/biomodels.db/BIOMD0000000081" -Suh2004_KCNQ_regulation identity "http://identifiers.org/kegg.pathway/map04070" -Suh2004_KCNQ_regulation taxon "http://identifiers.org/taxonomy/9606" -Suh2004_KCNQ_regulation description "http://identifiers.org/pubmed/15173220" diff --git a/BioModelsRAG/data/BIOMD0000000082.txt b/BioModelsRAG/data/BIOMD0000000082.txt deleted file mode 100644 index 78e3b5b7e521dc17e03724ae74b15c3c5d8866df..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000082.txt +++ /dev/null @@ -1,126 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Model_1() - - // Compartments and Species: - compartment cell; - species agonist in cell, DR in cell, DRG_GDP in cell, DRG in cell, GDP in cell; - species DRG_GTP in cell, GTP in cell, Recptor in cell, G_GDP in cell, G_GTP in cell; - - // Reactions: - Forming: agonist + Recptor -> DR; cell*(Forming_k1*agonist*Recptor - Forming_k7*DR); - reaction_1: DR + G_GDP -> DRG_GDP; cell*(reaction_1_k2*DR*G_GDP - reaction_1_k8*DRG_GDP); - reaction_2: DRG_GDP -> GDP + DRG; cell*(reaction_2_k3*DRG_GDP - reaction_2_k9*DRG*GDP); - reaction_3: DRG + GTP -> DRG_GTP; cell*(reaction_3_k4*DRG*GTP - reaction_3_k10*DRG_GTP); - reaction_4: DRG_GTP => G_GTP + DR; cell*reaction_4_k5*DRG_GTP; - reaction_5: G_GTP => G_GDP; cell*reaction_5_k6*G_GTP; - - // Species initializations: - agonist = 1e-08; - DR = 0; - DRG_GDP = 0; - DRG = 0; - GDP = 0; - DRG_GTP = 0; - GTP = 1e-05; - Recptor = 1e-09; - G_GDP = 1e-09; - G_GTP = 0; - - // Compartment initializations: - cell = 1; - - // Variable initializations: - Forming_k1 = 5000000; - Forming_k7 = 0.5; - reaction_1_k2 = 100000000; - reaction_1_k8 = 0.1; - reaction_2_k3 = 0.1; - reaction_2_k9 = 100000; - reaction_3_k4 = 10000000; - reaction_3_k10 = 0.1; - reaction_4_k5 = 0.05; - reaction_5_k6 = 0.1; - - // Other declarations: - const cell; - - // Display Names: - agonist is "D"; - Recptor is "R"; - Forming is "Forming DR"; - reaction_1 is "DR binding with G_GDP produc DRG_GDP"; - reaction_2 is "GDP releasing"; - reaction_3 is "GTP binding with DRG"; - reaction_4 is "DRG_GTP dissociates(G protein activation)"; - reaction_5 is "G protein inactivated"; - - // CV terms: - cell hypernym "http://identifiers.org/go/GO:0005623" - agonist hypernym "http://identifiers.org/chebi/CHEBI:35569" - DR part "http://identifiers.org/chebi/CHEBI:35569", - "http://identifiers.org/uniprot/P18825" - DR part "http://identifiers.org/chebi/CHEBI:35569", - "http://identifiers.org/uniprot/P08913" - DR part "http://identifiers.org/chebi/CHEBI:35569", - "http://identifiers.org/uniprot/P18089" - DRG_GDP part "http://identifiers.org/chebi/CHEBI:17552", - "http://identifiers.org/chebi/CHEBI:35569", - "http://identifiers.org/uniprot/P08913", - "http://identifiers.org/go/GO:0005834" - DRG_GDP part "http://identifiers.org/chebi/CHEBI:17552", - "http://identifiers.org/chebi/CHEBI:35569", - "http://identifiers.org/uniprot/P18089", - "http://identifiers.org/go/GO:0005834" - DRG_GDP part "http://identifiers.org/chebi/CHEBI:17552", - "http://identifiers.org/chebi/CHEBI:35569", - "http://identifiers.org/uniprot/P18825", - "http://identifiers.org/go/GO:0005834" - DRG part "http://identifiers.org/chebi/CHEBI:35569", - "http://identifiers.org/uniprot/P18089", - "http://identifiers.org/go/GO:0005834" - DRG part "http://identifiers.org/chebi/CHEBI:35569", - "http://identifiers.org/uniprot/P08913", - "http://identifiers.org/go/GO:0005834" - DRG part "http://identifiers.org/chebi/CHEBI:35569", - "http://identifiers.org/uniprot/P18825", - "http://identifiers.org/go/GO:0005834" - GDP identity "http://identifiers.org/chebi/CHEBI:17552" - DRG_GTP part "http://identifiers.org/chebi/CHEBI:15996", - "http://identifiers.org/chebi/CHEBI:35569", - "http://identifiers.org/uniprot/P08913", - "http://identifiers.org/go/GO:0005834" - DRG_GTP part "http://identifiers.org/chebi/CHEBI:15996", - "http://identifiers.org/chebi/CHEBI:35569", - "http://identifiers.org/uniprot/P18089", - "http://identifiers.org/go/GO:0005834" - DRG_GTP part "http://identifiers.org/chebi/CHEBI:15996", - "http://identifiers.org/chebi/CHEBI:35569", - "http://identifiers.org/uniprot/P18825", - "http://identifiers.org/go/GO:0005834" - GTP identity "http://identifiers.org/chebi/CHEBI:15996" - Recptor version "http://identifiers.org/uniprot/P08913", - "http://identifiers.org/uniprot/P18089", - "http://identifiers.org/uniprot/P18825" - G_GDP part "http://identifiers.org/chebi/CHEBI:17552", - "http://identifiers.org/go/GO:0005834" - G_GTP part "http://identifiers.org/chebi/CHEBI:15996", - "http://identifiers.org/go/GO:0005834" - Forming hypernym "http://identifiers.org/go/GO:0031690" - reaction_1 hypernym "http://identifiers.org/go/GO:0001664" - reaction_2 hypernym "http://identifiers.org/go/GO:0043241" - reaction_3 hypernym "http://identifiers.org/go/GO:0005525", - "http://identifiers.org/go/GO:0032403" - reaction_4 hypernym "http://identifiers.org/go/GO:0043241" - reaction_5 hypernym "http://identifiers.org/go/GO:0003924" -end - -Model_1 is "Thomsen1988_AdenylateCyclase_Inhibition" - -Model_1 model_entity_is "http://identifiers.org/biomodels.db/MODEL1166069080" -Model_1 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000082" -Model_1 description "http://identifiers.org/pubmed/2904647" -Model_1 origin "http://identifiers.org/pubmed/6248546", - "http://identifiers.org/pubmed/6277164" -Model_1 hypernym "http://identifiers.org/go/GO:0031684", - "http://identifiers.org/go/GO:0007194" -Model_1 taxon "http://identifiers.org/taxonomy/9606" diff --git a/BioModelsRAG/data/BIOMD0000000083.txt b/BioModelsRAG/data/BIOMD0000000083.txt deleted file mode 100644 index ce683feb6771c2be70b1d21f5890b808808c792c..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000083.txt +++ /dev/null @@ -1,356 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Leloup2003_CircClock_LD_REV_ERBalpha() - - // Compartments and Species: - compartment cell; - species Mb in cell, Bc in cell, Bcp in cell, Bn in cell, Cc in cell, Mc in cell; - species Ccp in cell, Mp in cell, Pc in cell, Pcp in cell, PCc in cell, PCcp in cell; - species PCn in cell, Bnp in cell, PCnp in cell, In in cell, Mr in cell; - species Rc in cell, Rn in cell; - - // Assignment Rules: - parameter_0000096 := ceil(sin(pi*time/12 + 0.001)/2); - parameter_0000097 := 2.4 + (3 - 2.4)*parameter_0000096; - - // Reactions: - reaction_0: => Mb; cell*(vsB*reaction_0_K^m/(reaction_0_K^m + Rn^m)); - reaction_1: => Bc; cell*ksB*Mb; - reaction_2: Mb => ; cell*kdmb*Mb; - reaction_3: Bc => Bcp; cell*(V1B*Bc/(Kp + Bc)); - reaction_4: Bc -> Bn; cell*(k5*Bc - k6*Bn); - reaction_5: => Cc; cell*ksC*Mc; - reaction_6: Mc => ; cell*kdmc*Mc; - reaction_7: Cc => Ccp; cell*(V1C*Cc/(Kp + Cc)); - reaction_8: Ccp => ; cell*(vdCC*Ccp/(Kd + Ccp)); - reaction_9: => Mp; cell*(parameter_0000097*Bn^n/(KAP^n + Bn^n)); - reaction_10: => Pc; cell*ksP*Mp; - reaction_11: Pcp => ; cell*(VdPC*Pcp/(Kd + Pcp)); - reaction_12: Pc => Pcp; cell*(V1P*Pc/(Kp + Pc)); - reaction_13: Cc + Pc -> PCc; cell*(k3*Cc*Pc - k4*PCc); - reaction_14: PCc => PCcp; cell*(V1PC*PCc/(Kp + PCc)); - reaction_15: PCcp => ; cell*(vdPCC*PCcp/(Kd + PCcp)); - reaction_16: PCc -> PCn; cell*(k1*PCc - k2*PCn); - reaction_17: PCnp => ; cell*kdn*PCnp; - reaction_18: Bcp => ; cell*kdn*Bcp; - reaction_19: Bnp => ; cell*kdn*Bnp; - reaction_20: => Mc; cell*(vsC*Bn^n/(KAC^n + Bn^n)); - reaction_21: PCn => PCnp; cell*(V3PC*PCn/(Kp + PCn)); - reaction_22: Mp => ; cell*kdmp*Mp; - reaction_23: PCn + Bn -> In; cell*(k7*PCn*Bn - k8*In); - reaction_24: Mb => ; cell*(vmB*Mb/(KmB + Mb)); - reaction_25: Mc => ; cell*(vmC*Mc/(KmC + Mc)); - reaction_26: Mp => ; cell*(vmP*Mp/(KmP + Mp)); - reaction_27: Pc => ; cell*kdn*Pc; - reaction_28: Cc => ; cell*kdnC*Cc; - reaction_29: Pcp => ; cell*kdn*Pcp; - reaction_30: Ccp => ; cell*kdn*Ccp; - reaction_31: PCcp => ; cell*kdn*PCcp; - reaction_32: PCc => ; cell*kdn*PCc; - reaction_33: PCnp => ; cell*(vdPCN*PCnp/(Kd + PCnp)); - reaction_34: Bc => ; cell*kdn*Bc; - reaction_35: Bcp => ; cell*(vdBC*Bcp/(Kd + Bcp)); - reaction_36: Bn => Bnp; cell*(V3B*Bn/(Kp + Bn)); - reaction_37: Bnp => ; cell*(vdBN*Bnp/(Kd + Bnp)); - reaction_38: In => ; cell*kdn*In; - reaction_39: In => ; cell*(vdIN*In/(Kd + In)); - reaction_40: Bn => ; cell*kdn*Bn; - reaction_41: Bcp => Bc; cell*(V2B*Bcp/(Kdp + Bcp)); - reaction_42: Bnp => Bn; cell*(V4B*Bnp/(Kdp + Bnp)); - reaction_43: Ccp => Cc; cell*(V2C*Ccp/(Kdp + Ccp)); - reaction_44: Pcp => Pc; cell*(V2P*Pcp/(Kdp + Pcp)); - reaction_45: PCnp => PCn; cell*(V4PC*PCnp/(Kdp + PCnp)); - reaction_46: PCn => ; cell*kdn*PCn; - reaction_47: PCcp => PCc; cell*(V2PC*PCcp/(Kdp + PCcp)); - reaction_48: => Mr; cell*(vsR*Bn^h/(KAR^h + Bn^h)); - reaction_49: Mr => ; cell*kdmr*Mr; - reaction_50: Mr => ; cell*(vmR*Mr/(kmR + Mr)); - reaction_51: => Rc; cell*ksR*Mr; - reaction_52: Rc -> Rn; cell*(k9*Rc - k10*Rn); - reaction_53: Rc => ; cell*(vdRC*Rc/(Kd + Rc)); - reaction_54: Rc => ; cell*kdn*Rc; - reaction_55: Rn => ; cell*(vdRN*Rn/(Kd + Rn)); - reaction_56: Rn => ; cell*kdn*Rn; - - // Species initializations: - Mb = 0; - Bc = 0; - Bcp = 0; - Bn = 0; - Cc = 0; - Mc = 0; - Ccp = 0; - Mp = 0; - Pc = 0; - Pcp = 0; - PCc = 0; - PCcp = 0; - PCn = 0; - Bnp = 0; - PCnp = 0; - In = 0; - Mr = 0; - Rc = 0; - Rn = 0; - - // Compartment initializations: - cell = 1; - - // Variable initializations: - vmP = 2.2; - kdmp = 0.02; - vsC = 2.2; - vmC = 2; - kdmc = 0.02; - vsB = 1.8; - vmB = 1.3; - kdmb = 0.02; - ksP = 1.2; - V1P = 9.6; - V2P = 0.6; - k4 = 0.4; - k3 = 0.8; - kdn = 0.02; - ksC = 3.2; - V1C = 1.2; - V2C = 0.2; - kdnC = 0.02; - KmB = 0.4; - Kp = 1.006; - Kdp = 0.1; - VdPC = 3.4; - vdCC = 1.4; - Kd = 0.3; - V1PC = 2.4; - V2PC = 0.2; - k2 = 0.4; - k1 = 0.8; - V3PC = 2.4; - V4PC = 0.2; - k7 = 1; - k8 = 0.2; - vdPCC = 1.4; - vdPCN = 1.4; - ksB = 0.32; - V1B = 1.4; - V2B = 0.2; - k5 = 0.8; - k6 = 0.4; - vdBC = 3; - V3B = 1.4; - V4B = 0.4; - vdBN = 3; - vdIN = 1.6; - vsR = 1.6; - KAR = 0.6; - vmR = 1.6; - kmR = 0.4; - kdmr = 0.02; - ksR = 1.7; - k9 = 0.8; - k10 = 0.4; - vdRC = 4.4; - vdRN = 0.8; - KAP = 0.6; - KAC = 0.6; - KmP = 0.3; - KmC = 0.4; - h = 2; - m = 2; - n = 2; - reaction_0_K = 1; - - // Other declarations: - var parameter_0000096, parameter_0000097; - const cell, vmP, kdmp, vsC, vmC, kdmc, vsB, vmB, kdmb, ksP, V1P, V2P, k4; - const k3, kdn, ksC, V1C, V2C, kdnC, KmB, Kp, Kdp, VdPC, vdCC, Kd, V1PC; - const V2PC, k2, k1, V3PC, V4PC, k7, k8, vdPCC, vdPCN, ksB, V1B, V2B, k5; - const k6, vdBC, V3B, V4B, vdBN, vdIN, vsR, KAR, vmR, kmR, kdmr, ksR, k9; - const k10, vdRC, vdRN, KAP, KAC, KmP, KmC, h, m, n; - - // Unit definitions: - unit time_unit = 3600 second; - unit substance = 1e-9 mole; - - // Display Names: - time_unit is "time"; - parameter_0000096 is "LD"; - parameter_0000097 is "vsp"; - reaction_0 is "Mb synthesized"; - reaction_1 is "Mb translated into protein"; - reaction_2 is "Mb nonspecific degradation"; - reaction_3 is "Bc phosphorylation"; - reaction_4 is "Bc transfered from cytosolic to nuclear"; - reaction_5 is "Mc translated into protein"; - reaction_6 is "Mc nonspecific degradation"; - reaction_7 is "Cc phosphorylation"; - reaction_8 is "Ccp specific degradation"; - reaction_9 is "Mp synthesis"; - reaction_10 is "Mp translated into protein"; - reaction_11 is "Pcp specific degradation"; - reaction_12 is "Pc phospholation"; - reaction_13 is "Cc and Pc produce PCc"; - reaction_14 is "PCc phospholation"; - reaction_15 is "PCcp specific degradation"; - reaction_16 is "PCc transfered into nuclear"; - reaction_17 is "PCnp nonspecific degradation"; - reaction_18 is "Bcp nonspecific degradation"; - reaction_19 is "Bnp nonspecific degradation"; - reaction_20 is "Mc synthesis"; - reaction_21 is "PCn phospholation"; - reaction_22 is "Mp nonspecific degradation"; - reaction_23 is "Per_Cry and Clock_Bmal form inactive complex"; - reaction_24 is "Mb specific degradation"; - reaction_25 is "Mc specific degradation"; - reaction_26 is "Mp specific degradation"; - reaction_27 is "Pc nonspecific degradation"; - reaction_28 is "Cc nonspecific degradation"; - reaction_29 is "Pcp nonspecific degradation"; - reaction_30 is "Ccp nonspecific degradation"; - reaction_31 is "PCcp nonspecific degradation"; - reaction_32 is "PCc nonspecific degradation"; - reaction_33 is "PCnp specific degradation"; - reaction_34 is "Bc nonspecific degradation"; - reaction_35 is "Bcp specific degradation"; - reaction_36 is "Bn phospholation"; - reaction_37 is "Bnp specific degradation"; - reaction_38 is "In nonspecific degration"; - reaction_39 is "In specific degradation"; - reaction_40 is "Bn nonspecific degradation"; - reaction_41 is "Bcp dephospholation"; - reaction_42 is "Bnp dephospholation"; - reaction_43 is "Ccp dephospholation"; - reaction_44 is "Pcp dephospholation"; - reaction_45 is "PCnp dephospholation"; - reaction_46 is "PCn nonspecific degradation"; - reaction_47 is "PCcp dephospholation"; - reaction_48 is "Mr synthesized"; - reaction_49 is "Mr nonspecific degradation"; - reaction_50 is "Mr specific degradation"; - reaction_51 is "Mr translated into protein"; - reaction_52 is "Rc transfered into nuclear"; - reaction_53 is "Rc specific degradation"; - reaction_54 is "Rc nonspecific degradation"; - reaction_55 is "Rn specific degradation"; - reaction_56 is "Rn nonspecific degradation"; - - // CV terms: - cell hypernym "http://identifiers.org/go/GO:0005623" - Mb encodement "http://identifiers.org/uniprot/O00327" - Mb hypernym "http://identifiers.org/chebi/CHEBI:33699" - Bc version "http://identifiers.org/uniprot/O00327" - Bcp version "http://identifiers.org/uniprot/O00327" - Bn version "http://identifiers.org/uniprot/O00327" - Cc version "http://identifiers.org/uniprot/Q8IV71" - Cc version "http://identifiers.org/uniprot/Q16526" - Mc encodement "http://identifiers.org/uniprot/Q16526" - Mc encodement "http://identifiers.org/uniprot/Q8IV71" - Mc hypernym "http://identifiers.org/chebi/CHEBI:33699" - Ccp version "http://identifiers.org/uniprot/Q8IV71" - Ccp version "http://identifiers.org/uniprot/Q16526" - Mp encodement "http://identifiers.org/uniprot/P56645" - Mp encodement "http://identifiers.org/uniprot/O15055" - Mp encodement "http://identifiers.org/uniprot/O15534" - Mp hypernym "http://identifiers.org/chebi/CHEBI:33699" - Pc version "http://identifiers.org/uniprot/O15055" - Pc version "http://identifiers.org/uniprot/O15534" - Pc version "http://identifiers.org/uniprot/P56645" - Pcp version "http://identifiers.org/uniprot/O15534" - Pcp version "http://identifiers.org/uniprot/O15055" - Pcp version "http://identifiers.org/uniprot/P56645" - PCc part "http://identifiers.org/uniprot/Q16526" - PCc part "http://identifiers.org/uniprot/O15534" - PCc part "http://identifiers.org/uniprot/Q8IV71" - PCc part "http://identifiers.org/uniprot/P56645" - PCcp part "http://identifiers.org/uniprot/P56645" - PCcp part "http://identifiers.org/uniprot/O15534" - PCcp part "http://identifiers.org/uniprot/Q16526" - PCcp part "http://identifiers.org/uniprot/Q8IV71" - PCn part "http://identifiers.org/uniprot/Q8IV71" - PCn part "http://identifiers.org/uniprot/Q16526" - PCn part "http://identifiers.org/uniprot/P56645" - PCn part "http://identifiers.org/uniprot/O15534" - Bnp version "http://identifiers.org/uniprot/O00327" - PCnp part "http://identifiers.org/uniprot/P56645" - PCnp part "http://identifiers.org/uniprot/Q8IV71" - PCnp part "http://identifiers.org/uniprot/Q16526" - PCnp part "http://identifiers.org/uniprot/O15534" - Mr encodement "http://identifiers.org/uniprot/Q6EEZ7" - Mr hypernym "http://identifiers.org/chebi/CHEBI:33699" - Rc version "http://identifiers.org/uniprot/Q6EEZ7" - Rn version "http://identifiers.org/uniprot/Q6EEZ7" - reaction_0 hypernym "http://identifiers.org/go/GO:0045892" - reaction_1 hypernym "http://identifiers.org/go/GO:0006412" - reaction_2 hypernym "http://identifiers.org/go/GO:0044257" - reaction_3 hypernym "http://identifiers.org/go/GO:0006468" - reaction_4 hypernym "http://identifiers.org/go/GO:0000060" - reaction_5 hypernym "http://identifiers.org/go/GO:0006412" - reaction_6 hypernym "http://identifiers.org/go/GO:0044257" - reaction_7 hypernym "http://identifiers.org/go/GO:0006468" - reaction_8 hypernym "http://identifiers.org/go/GO:0008233" - reaction_9 hypernym "http://identifiers.org/go/GO:0045893" - reaction_10 hypernym "http://identifiers.org/go/GO:0006412" - reaction_11 hypernym "http://identifiers.org/go/GO:0008233" - reaction_12 hypernym "http://identifiers.org/go/GO:0006468" - reaction_13 hypernym "http://identifiers.org/go/GO:0043623" - reaction_14 hypernym "http://identifiers.org/go/GO:0006468" - reaction_15 hypernym "http://identifiers.org/go/GO:0008233" - reaction_16 hypernym "http://identifiers.org/go/GO:0000060" - reaction_17 hypernym "http://identifiers.org/go/GO:0044257" - reaction_18 hypernym "http://identifiers.org/go/GO:0044257" - reaction_19 hypernym "http://identifiers.org/go/GO:0044257" - reaction_20 parthood "http://identifiers.org/go/GO:0045893" - reaction_21 hypernym "http://identifiers.org/go/GO:0006468" - reaction_22 hypernym "http://identifiers.org/go/GO:0044257" - reaction_23 hypernym "http://identifiers.org/go/GO:0043623" - reaction_24 hypernym "http://identifiers.org/go/GO:0008233" - reaction_25 hypernym "http://identifiers.org/go/GO:0008233" - reaction_26 hypernym "http://identifiers.org/go/GO:0008233" - reaction_27 hypernym "http://identifiers.org/go/GO:0044257" - reaction_28 hypernym "http://identifiers.org/go/GO:0044257" - reaction_29 hypernym "http://identifiers.org/go/GO:0044257" - reaction_30 hypernym "http://identifiers.org/go/GO:0044257" - reaction_31 hypernym "http://identifiers.org/go/GO:0044257" - reaction_32 hypernym "http://identifiers.org/go/GO:0044257" - reaction_33 hypernym "http://identifiers.org/go/GO:0008233" - reaction_34 hypernym "http://identifiers.org/go/GO:0044257" - reaction_35 hypernym "http://identifiers.org/go/GO:0008233" - reaction_36 hypernym "http://identifiers.org/go/GO:0006468" - reaction_37 hypernym "http://identifiers.org/go/GO:0008233" - reaction_38 hypernym "http://identifiers.org/go/GO:0044257" - reaction_39 hypernym "http://identifiers.org/go/GO:0008233" - reaction_40 hypernym "http://identifiers.org/go/GO:0044257" - reaction_41 hypernym "http://identifiers.org/go/GO:0006470" - reaction_42 hypernym "http://identifiers.org/go/GO:0006470" - reaction_43 parthood "http://identifiers.org/go/GO:0006470" - reaction_44 hypernym "http://identifiers.org/go/GO:0006470" - reaction_45 hypernym "http://identifiers.org/go/GO:0006470" - reaction_46 hypernym "http://identifiers.org/go/GO:0044257" - reaction_47 hypernym "http://identifiers.org/go/GO:0006470" - reaction_48 parthood "http://identifiers.org/go/GO:0045893" - reaction_49 hypernym "http://identifiers.org/go/GO:0044257" - reaction_50 hypernym "http://identifiers.org/go/GO:0008233" - reaction_51 hypernym "http://identifiers.org/go/GO:0006412" - reaction_52 hypernym "http://identifiers.org/go/GO:0000060" - reaction_53 hypernym "http://identifiers.org/go/GO:0008233" - reaction_54 hypernym "http://identifiers.org/go/GO:0044257" - reaction_55 hypernym "http://identifiers.org/go/GO:0008233" - reaction_56 hypernym "http://identifiers.org/go/GO:0044257" -end - -Leloup2003_CircClock_LD_REV_ERBalpha is "Leloup2003_CircClock_LD_REV-ERBalpha" - -Leloup2003_CircClock_LD_REV_ERBalpha origin "http://identifiers.org/kegg.pathway/hsa04710", - "http://identifiers.org/biomodels.db/BIOMD0000000083", - "http://identifiers.org/biomodels.db/MODEL4710748444", - "http://identifiers.org/go/GO:0042752", - "http://identifiers.org/taxonomy/40674", - "http://identifiers.org/biomodels.db/BIOMD0000000021" -Leloup2003_CircClock_LD_REV_ERBalpha model_entity_is "http://identifiers.org/biomodels.db/MODEL4710748444", - "http://identifiers.org/biomodels.db/BIOMD0000000083" -Leloup2003_CircClock_LD_REV_ERBalpha version "http://identifiers.org/kegg.pathway/hsa04710" -Leloup2003_CircClock_LD_REV_ERBalpha identity "http://identifiers.org/biomodels.db/BIOMD0000000083" -Leloup2003_CircClock_LD_REV_ERBalpha identity "http://identifiers.org/biomodels.db/MODEL4710748444" -Leloup2003_CircClock_LD_REV_ERBalpha hypernym "http://identifiers.org/go/GO:0042752" -Leloup2003_CircClock_LD_REV_ERBalpha taxon "http://identifiers.org/taxonomy/40674" -Leloup2003_CircClock_LD_REV_ERBalpha description "http://identifiers.org/biomodels.db/BIOMD0000000021", - "http://identifiers.org/pubmed/12775757" diff --git a/BioModelsRAG/data/BIOMD0000000084.txt b/BioModelsRAG/data/BIOMD0000000084.txt deleted file mode 100644 index 5eeca632778c0ec3e0f86f2c0d4c56a1c6d69159..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000084.txt +++ /dev/null @@ -1,103 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Hornberg2005_ERKcascade() - - // Compartments and Species: - compartment compartment_; - substanceOnly species R in compartment_, Rin in compartment_, x1 in compartment_; - substanceOnly species x1p in compartment_, x2 in compartment_, x2p in compartment_; - substanceOnly species x3 in compartment_, x3p in compartment_; - - // Reactions: - v1: R -> Rin; v1_Vm1*R/(v1_Km1 + R); - v2: Rin -> R; v2_Vm2*Rin/(v2_Km2 + Rin); - v3: x1 -> x1p; v3_k3*R*x1/(v3_Km3 + x1); - v4: x1p -> x1; v4_Vm4*x1p/(v4_Km4 + x1p); - v5: x2 -> x2p; v5_k5*x1p*x2/(v5_Km5 + x2); - v6: x2p -> x2; v6_Vm6*x2p/(v6_Km6 + x2p); - v7: x3 -> x3p; v7_k7*x2p*x3/(v7_Km7 + x3); - v8: x3p -> x3; v8_Vm8*x3p/v8_Km8/(1 + x3p/v8_Km8 + v8_Inh/v8_Ki8); - - // Species initializations: - R = 0.5/compartment_; - Rin = 0; - x1 = 1/compartment_; - x1p = 0; - x2 = 1/compartment_; - x2p = 0; - x3 = 1/compartment_; - x3p = 0; - - // Compartment initializations: - compartment_ = 1; - - // Variable initializations: - v1_Vm1 = 1; - v1_Km1 = 0.1; - v2_Vm2 = 0.01; - v2_Km2 = 0.1; - v3_k3 = 1; - v3_Km3 = 0.1; - v4_Vm4 = 0.3; - v4_Km4 = 1; - v5_k5 = 1; - v5_Km5 = 0.1; - v6_Vm6 = 0.3; - v6_Km6 = 1; - v7_k7 = 1; - v7_Km7 = 0.1; - v8_Vm8 = 0.3; - v8_Km8 = 1; - v8_Inh = 0; - v8_Ki8 = 1; - - // Other declarations: - const compartment_; - - // Unit definitions: - unit substance = item; - - // Display Names: - substance is "dimensionless"; - compartment_ is "Cytosol"; - v1 is "Receptor inactivation"; - v2 is "Receptor activation"; - v3 is "Kinase-1 activation"; - v4 is "Kinase-1 inactivation"; - v5 is "Kinase-2 activation"; - v6 is "Kinase-2 inactivation"; - v7 is "Kinase-3 activation"; - v8 is "Kinase-3 inactivation"; - - // CV terms: - compartment_ identity "http://identifiers.org/obo.go/GO:0005829" - R hypernym "http://identifiers.org/uniprot/Q9QX70" - Rin hypernym "http://identifiers.org/uniprot/Q9QX70" - x1 hypernym "http://identifiers.org/uniprot/P04049" - x1p hypernym "http://identifiers.org/uniprot/P04049" - x2 hypernym "http://identifiers.org/uniprot/Q02750" - x2p hypernym "http://identifiers.org/uniprot/Q02750" - x3 hypernym "http://identifiers.org/uniprot/P28482" - x3p hypernym "http://identifiers.org/uniprot/P28482" - v1 hypernym "http://identifiers.org/obo.go/GO:0007175" - v2 hypernym "http://identifiers.org/obo.go/GO:0045741" - v3 identity "http://identifiers.org/obo.go/GO:0000185" - v4 identity "http://identifiers.org/obo.go/GO:0051390" - v5 identity "http://identifiers.org/ec-code/2.7.11.1", - "http://identifiers.org/obo.go/GO:0000186", - "http://identifiers.org/obo.go/GO:0004709" - v6 identity "http://identifiers.org/obo.go/GO:0051389" - v7 identity "http://identifiers.org/ec-code/2.7.12.2", - "http://identifiers.org/obo.go/GO:0000187", - "http://identifiers.org/obo.go/GO:0004708" - v8 hypernym "http://identifiers.org/obo.go/GO:0043407" -end - -Hornberg2005_ERKcascade is "Hornberg2005_ERKcascade" - -Hornberg2005_ERKcascade model_entity_is "http://identifiers.org/biomodels.db/MODEL6623610941" -Hornberg2005_ERKcascade model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000084" -Hornberg2005_ERKcascade description "http://identifiers.org/pubmed/15634347" -Hornberg2005_ERKcascade identity "http://identifiers.org/obo.go/GO:0000165", - "http://identifiers.org/obo.go/GO:0007173" -Hornberg2005_ERKcascade part "http://identifiers.org/kegg.pathway/rno04010" -Hornberg2005_ERKcascade taxon "http://identifiers.org/taxonomy/40674" diff --git a/BioModelsRAG/data/BIOMD0000000085.txt b/BioModelsRAG/data/BIOMD0000000085.txt deleted file mode 100644 index 8915847cbacf5399656038712d25259e673a6876..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000085.txt +++ /dev/null @@ -1,216 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Maurya2005() - - // Compartments and Species: - compartment compartment_0; - species species_0 in compartment_0, species_1 in compartment_0, species_2 in compartment_0; - species species_3 in compartment_0, species_4 in compartment_0, species_5 in compartment_0; - species species_6 in compartment_0, species_7 in compartment_0, species_8 in compartment_0; - species species_9 in compartment_0, species_10 in compartment_0, species_11 in compartment_0; - species species_12 in compartment_0, species_13 in compartment_0, species_14 in compartment_0; - species species_15 in compartment_0, species_16 in compartment_0; - - // Assignment Rules: - parameter_0 := (species_5 + species_10 + species_15 + species_11)/1e-8; - parameter_1 := (25*species_15 + 25*species_11 + 0.013*species_10 + 0.013*species_5)/10e-9; - - // Reactions: - reaction_1: species_1 + species_3 -> species_5; compartment_0*(reaction_1_k1*species_1*species_3 - reaction_1_k2*species_5); - reaction_3: species_5 -> species_6 + species_7; compartment_0*(reaction_3_k1*species_5 - reaction_3_k2*species_6*species_7); - reaction_4: species_6 -> species_1 + species_8; compartment_0*(reaction_4_k1*species_6 - reaction_4_k2*species_1*species_8); - reaction_5: species_9 + species_3 -> species_10; compartment_0*(reaction_5_k1*species_9*species_3 - reaction_5_k2*species_10); - reaction_6: species_5 + species_4 -> species_10; compartment_0*(reaction_6_k1*species_5*species_4 - reaction_6_k2*species_10); - reaction_7: species_5 + species_0 -> species_11; compartment_0*(reaction_7_k1*species_5*species_0 - reaction_7_k2*species_11); - reaction_8: species_6 + species_0 -> species_12; compartment_0*(reaction_8_k1*species_6*species_0 - reaction_8_k2*species_12); - reaction_9: species_6 + species_4 -> species_13; compartment_0*(reaction_9_k1*species_6*species_4 - reaction_9_k2*species_13); - reaction_10: species_10 -> species_13 + species_7; compartment_0*(reaction_10_k1*species_10 - reaction_10_k2*species_13*species_7); - reaction_11: species_13 -> species_9 + species_8; compartment_0*(reaction_11_k1*species_13 - reaction_11_k2*species_9*species_8); - reaction_13: species_11 -> species_12 + species_7; compartment_0*(reaction_13_k1*species_11 - reaction_13_k2*species_12*species_7); - reaction_14: species_12 -> species_2 + species_8; compartment_0*(reaction_14_k1*species_12 - reaction_14_k2*species_2*species_8); - reaction_16: species_2 + species_4 -> species_14; compartment_0*(reaction_16_k1*species_2*species_4 - reaction_16_k2*species_14); - reaction_17: species_14 + species_3 -> species_15; compartment_0*(reaction_17_k1*species_14*species_3 - reaction_17_k2*species_15); - reaction_19: species_10 + species_0 -> species_15; compartment_0*(reaction_19_k1*species_10*species_0 - reaction_19_k2*species_15); - reaction_20: species_15 -> species_16 + species_7; compartment_0*(reaction_20_k1*species_15 - reaction_20_k2*species_16*species_7); - reaction_23: species_16 -> species_14 + species_8; compartment_0*(reaction_23_k1*species_16 - reaction_23_k2*species_14*species_8); - - // Species initializations: - species_0 = 0; - species_1 = 1e-08; - species_2 = 0; - species_3 = 0.000468; - species_4 = 1e-05; - species_5 = 0; - species_6 = 0; - species_7 = 0.0044; - species_8 = 0.000149; - species_9 = 0; - species_10 = 0; - species_11 = 0; - species_12 = 0; - species_13 = 0; - species_14 = 0; - species_15 = 0; - species_16 = 0; - - // Compartment initializations: - compartment_0 = 1; - - // Variable initializations: - reaction_1_k1 = 529000; - reaction_1_k2 = 8.38e-06; - reaction_3_k1 = 0.013; - reaction_3_k2 = 9.03e-07; - reaction_4_k1 = 0.0001; - reaction_4_k2 = 62.3; - reaction_5_k1 = 853000; - reaction_5_k2 = 0.00468; - reaction_6_k1 = 132000000; - reaction_6_k2 = 1.28; - reaction_7_k1 = 386000; - reaction_7_k2 = 0.0408; - reaction_8_k1 = 64100; - reaction_8_k2 = 0.95; - reaction_9_k1 = 94700000; - reaction_9_k2 = 0.00227; - reaction_10_k1 = 0.013; - reaction_10_k2 = 2.22e-09; - reaction_11_k1 = 2; - reaction_11_k2 = 1470000; - reaction_13_k1 = 25; - reaction_13_k2 = 0.244; - reaction_14_k1 = 0.0001; - reaction_14_k2 = 3.83; - reaction_16_k1 = 3960000000; - reaction_16_k2 = 5.43e-05; - reaction_17_k1 = 1620000; - reaction_17_k2 = 0.00875; - reaction_19_k1 = 6300000; - reaction_19_k2 = 0.478; - reaction_20_k1 = 25; - reaction_20_k2 = 0.00297; - reaction_23_k1 = 2.75; - reaction_23_k2 = 2940; - - // Other declarations: - var parameter_0, parameter_1; - const compartment_0; - - // Display Names: - compartment_0 is "cell"; - species_0 is "A"; - species_1 is "G"; - species_2 is "GA"; - species_3 is "T"; - species_4 is "R"; - species_5 is "G*T"; - species_6 is "GD"; - species_7 is "Pi"; - species_8 is "D"; - species_9 is "RG"; - species_10 is "RG*T"; - species_11 is "G*AT"; - species_12 is "GAD"; - species_13 is "RGD"; - species_14 is "RGA"; - species_15 is "RG*AT"; - species_16 is "RGAD"; - parameter_0 is "Z"; - parameter_1 is "v"; - reaction_1 is "G protein binding GTP"; - reaction_3 is "G*T hydrolysis"; - reaction_4 is "GD dissociation"; - reaction_5 is "RG binding GTP"; - reaction_6 is "G*T binding Receptor"; - reaction_7 is "G*T binding GAP"; - reaction_8 is "GD binding GAP"; - reaction_9 is "GD binding Receptor"; - reaction_10 is "RG*T hydrolysis"; - reaction_11 is "RGD dissociation"; - reaction_13 is "G*AT hydrolysis"; - reaction_14 is "GAD dissociation"; - reaction_16 is "GA binding Receptor"; - reaction_17 is "RGA binding GTP"; - reaction_19 is "RG*T binding GAP"; - reaction_20 is "RG*AT hydrolysis"; - reaction_23 is "RGAD dissociation"; - - // CV terms: - compartment_0 hypernym "http://identifiers.org/go/GO:0005623" - species_0 hypernym "http://identifiers.org/interpro/IPR000342" - species_1 hypernym "http://identifiers.org/go/GO:0005834" - species_2 part "http://identifiers.org/interpro/IPR000342", - "http://identifiers.org/go/GO:0005834" - species_3 identity "http://identifiers.org/chebi/CHEBI:15996", - "http://identifiers.org/kegg.compound/C00044" - species_4 hypernym "http://identifiers.org/go/GO:0043235" - species_4 version "http://identifiers.org/interpro/IPR000337" - species_5 part "http://identifiers.org/chebi/CHEBI:15996", - "http://identifiers.org/go/GO:0005834" - species_6 identity "http://identifiers.org/chebi/CHEBI:17552", - "http://identifiers.org/go/GO:0005834" - species_7 identity "http://identifiers.org/chebi/CHEBI:18367" - species_8 identity "http://identifiers.org/chebi/CHEBI:17552", - "http://identifiers.org/kegg.compound/C00035" - species_9 part "http://identifiers.org/go/GO:0005834", - "http://identifiers.org/go/GO:0043235" - species_10 part "http://identifiers.org/chebi/CHEBI:15996", - "http://identifiers.org/go/GO:0005834", - "http://identifiers.org/go/GO:0043235" - species_11 part "http://identifiers.org/chebi/CHEBI:15996", - "http://identifiers.org/interpro/IPR000342", - "http://identifiers.org/go/GO:0005834" - species_12 part "http://identifiers.org/chebi/CHEBI:17552", - "http://identifiers.org/interpro/IPR000342", - "http://identifiers.org/go/GO:0005834" - species_13 part "http://identifiers.org/chebi/CHEBI:17552", - "http://identifiers.org/go/GO:0005834", - "http://identifiers.org/go/GO:0043235" - species_14 part "http://identifiers.org/interpro/IPR000342", - "http://identifiers.org/go/GO:0005834", - "http://identifiers.org/go/GO:0043235" - species_15 part "http://identifiers.org/chebi/CHEBI:15996", - "http://identifiers.org/interpro/IPR000342", - "http://identifiers.org/go/GO:0005834", - "http://identifiers.org/go/GO:0043235" - species_16 part "http://identifiers.org/chebi/CHEBI:17552", - "http://identifiers.org/interpro/IPR000342", - "http://identifiers.org/go/GO:0005834", - "http://identifiers.org/go/GO:0043235" - reaction_1 hypernym "http://identifiers.org/go/GO:0005525", - "http://identifiers.org/go/GO:0005515" - reaction_3 version "http://identifiers.org/reactome/REACT_348" - reaction_3 hypernym "http://identifiers.org/go/GO:0003924" - reaction_4 hypernym "http://identifiers.org/go/GO:0043241" - reaction_5 hypernym "http://identifiers.org/go/GO:0005525", - "http://identifiers.org/go/GO:0032403" - reaction_6 hypernym "http://identifiers.org/go/GO:0005102", - "http://identifiers.org/go/GO:0001664" - reaction_7 hypernym "http://identifiers.org/go/GO:0032403" - reaction_8 hypernym "http://identifiers.org/go/GO:0032403" - reaction_9 hypernym "http://identifiers.org/go/GO:0005102", - "http://identifiers.org/go/GO:0001664" - reaction_10 hypernym "http://identifiers.org/go/GO:0003924" - reaction_10 version "http://identifiers.org/reactome/REACT_348" - reaction_11 hypernym "http://identifiers.org/go/GO:0043241" - reaction_13 hypernym "http://identifiers.org/go/GO:0003924" - reaction_13 version "http://identifiers.org/reactome/REACT_348" - reaction_14 hypernym "http://identifiers.org/go/GO:0043241" - reaction_16 hypernym "http://identifiers.org/go/GO:0005102", - "http://identifiers.org/go/GO:0001664" - reaction_17 hypernym "http://identifiers.org/go/GO:0005525", - "http://identifiers.org/go/GO:0032403" - reaction_19 hypernym "http://identifiers.org/go/GO:0032403", - "http://identifiers.org/go/GO:0005102" - reaction_20 hypernym "http://identifiers.org/go/GO:0003924" - reaction_20 version "http://identifiers.org/reactome/REACT_348" - reaction_23 hypernym "http://identifiers.org/go/GO:0043241" -end - -Maurya2005 is "Maurya2005_GTPaseCycle_reducedOrder" - -Maurya2005 model_entity_is "http://identifiers.org/biomodels.db/MODEL5317679037" -Maurya2005 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000085" -Maurya2005 description "http://identifiers.org/pubmed/16986265" -Maurya2005 origin "http://identifiers.org/biomodels.db/BIOMD0000000086" -Maurya2005 taxon "http://identifiers.org/taxonomy/131567" -Maurya2005 hypernym "http://identifiers.org/go/GO:0008277" diff --git a/BioModelsRAG/data/BIOMD0000000086.txt b/BioModelsRAG/data/BIOMD0000000086.txt deleted file mode 100644 index e11aac710866afbeffc8770925e18ea203924137..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000086.txt +++ /dev/null @@ -1,252 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Model_0() - - // Compartments and Species: - compartment compartment_0; - species species_0 in compartment_0, species_1 in compartment_0, species_2 in compartment_0; - species species_3 in compartment_0, species_4 in compartment_0, species_5 in compartment_0; - species species_6 in compartment_0, species_7 in compartment_0, species_8 in compartment_0; - species species_9 in compartment_0, species_10 in compartment_0, species_11 in compartment_0; - species species_12 in compartment_0, species_13 in compartment_0, species_14 in compartment_0; - species species_15 in compartment_0, species_16 in compartment_0; - - // Assignment Rules: - parameter_0 := (species_5 + species_10 + species_15 + species_11)/1e-8; - parameter_1 := (25*species_15 + 25*species_11 + 0.013*species_10 + 0.013*species_5)/1e-8; - - // Reactions: - reaction_0: species_1 + species_0 -> species_2; compartment_0*(reaction_0_k1*species_1*species_0 - reaction_0_k2*species_2); - reaction_1: species_1 + species_3 -> species_5; compartment_0*(reaction_1_k1*species_1*species_3 - reaction_1_k2*species_5); - reaction_2: species_1 + species_4 -> species_9; compartment_0*(reaction_2_k1*species_1*species_4 - reaction_2_k2*species_9); - reaction_3: species_5 -> species_6 + species_7; compartment_0*(reaction_3_k1*species_5 - reaction_3_k2*species_6*species_7); - reaction_4: species_6 -> species_1 + species_8; compartment_0*(reaction_4_k1*species_6 - reaction_4_k2*species_1*species_8); - reaction_5: species_9 + species_3 -> species_10; compartment_0*(reaction_5_k1*species_9*species_3 - reaction_5_k2*species_10); - reaction_6: species_5 + species_4 -> species_10; compartment_0*(reaction_6_k1*species_5*species_4 - reaction_6_k2*species_10); - reaction_7: species_5 + species_0 -> species_11; compartment_0*(reaction_7_k1*species_5*species_0 - reaction_7_k2*species_11); - reaction_8: species_6 + species_0 -> species_12; compartment_0*(reaction_8_k1*species_6*species_0 - reaction_8_k2*species_12); - reaction_9: species_6 + species_4 -> species_13; compartment_0*(reaction_9_k1*species_6*species_4 - reaction_9_k2*species_13); - reaction_10: species_10 -> species_13 + species_7; compartment_0*(reaction_10_k1*species_10 - reaction_10_k2*species_13*species_7); - reaction_11: species_13 -> species_9 + species_8; compartment_0*(reaction_11_k1*species_13 - reaction_11_k2*species_9*species_8); - reaction_12: species_2 + species_3 -> species_11; compartment_0*(reaction_12_k1*species_2*species_3 - reaction_12_k2*species_11); - reaction_13: species_11 -> species_12 + species_7; compartment_0*(reaction_13_k1*species_11 - reaction_13_k2*species_12*species_7); - reaction_14: species_12 -> species_2 + species_8; compartment_0*(reaction_14_k1*species_12 - reaction_14_k2*species_2*species_8); - reaction_15: species_9 + species_0 -> species_14; compartment_0*(reaction_15_k1*species_9*species_0 - reaction_15_k2*species_14); - reaction_16: species_2 + species_4 -> species_14; compartment_0*(reaction_16_k1*species_2*species_4 - reaction_16_k2*species_14); - reaction_17: species_14 + species_3 -> species_15; compartment_0*(reaction_17_k1*species_14*species_3 - reaction_17_k2*species_15); - reaction_18: species_11 + species_4 -> species_15; compartment_0*(reaction_18_k1*species_11*species_4 - reaction_18_k2*species_15); - reaction_19: species_10 + species_0 -> species_15; compartment_0*(reaction_19_k1*species_10*species_0 - reaction_19_k2*species_15); - reaction_20: species_15 -> species_16 + species_7; compartment_0*(reaction_20_k1*species_15 - reaction_20_k2*species_16*species_7); - reaction_21: species_13 + species_0 -> species_16; compartment_0*(reaction_21_k1*species_13*species_0 - reaction_21_k2*species_16); - reaction_22: species_12 + species_4 -> species_16; compartment_0*(reaction_22_k1*species_12*species_4 - reaction_22_k2*species_16); - reaction_23: species_16 -> species_14 + species_8; compartment_0*(reaction_23_k1*species_16 - reaction_23_k2*species_14*species_8); - - // Species initializations: - species_0 = 0; - species_1 = 1e-08; - species_2 = 0; - species_3 = 0.000468; - species_4 = 1e-06; - species_5 = 0; - species_6 = 0; - species_7 = 0.0044; - species_8 = 0.000149; - species_9 = 0; - species_10 = 0; - species_11 = 0; - species_12 = 0; - species_13 = 0; - species_14 = 0; - species_15 = 0; - species_16 = 0; - - // Compartment initializations: - compartment_0 = 1; - - // Variable initializations: - reaction_0_k1 = 8780000; - reaction_0_k2 = 8; - reaction_1_k1 = 529000; - reaction_1_k2 = 8.38e-06; - reaction_2_k1 = 636000000; - reaction_2_k2 = 0.0179; - reaction_3_k1 = 0.013; - reaction_3_k2 = 9.03e-07; - reaction_4_k1 = 0.0001; - reaction_4_k2 = 62.3; - reaction_5_k1 = 853000; - reaction_5_k2 = 0.00468; - reaction_6_k1 = 132000000; - reaction_6_k2 = 1.28; - reaction_7_k1 = 386000; - reaction_7_k2 = 0.0408; - reaction_8_k1 = 64100; - reaction_8_k2 = 0.95; - reaction_9_k1 = 94700000; - reaction_9_k2 = 0.00227; - reaction_10_k1 = 0.013; - reaction_10_k2 = 2.22e-09; - reaction_11_k1 = 2; - reaction_11_k2 = 1470000; - reaction_12_k1 = 44700; - reaction_12_k2 = 8.32e-08; - reaction_13_k1 = 25; - reaction_13_k2 = 0.244; - reaction_14_k1 = 0.0001; - reaction_14_k2 = 3.83; - reaction_15_k1 = 74300; - reaction_15_k2 = 0.00572; - reaction_16_k1 = 22800000; - reaction_16_k2 = 5.43e-05; - reaction_17_k1 = 1620000; - reaction_17_k2 = 0.00875; - reaction_18_k1 = 6200000; - reaction_18_k2 = 0.0433; - reaction_19_k1 = 6300000; - reaction_19_k2 = 0.478; - reaction_20_k1 = 25; - reaction_20_k2 = 0.00297; - reaction_21_k1 = 13000; - reaction_21_k2 = 0.685; - reaction_22_k1 = 49400000; - reaction_22_k2 = 0.00421; - reaction_23_k1 = 2.75; - reaction_23_k2 = 2940; - - // Other declarations: - var parameter_0, parameter_1; - const compartment_0; - - // Display Names: - compartment_0 is "cell"; - species_0 is "A"; - species_1 is "G"; - species_2 is "GA"; - species_3 is "T"; - species_4 is "R"; - species_5 is "G*T"; - species_6 is "GD"; - species_7 is "Pi"; - species_8 is "D"; - species_9 is "RG"; - species_10 is "RG*T"; - species_11 is "G*AT"; - species_12 is "GAD"; - species_13 is "RGD"; - species_14 is "RGA"; - species_15 is "RG*AT"; - species_16 is "RGAD"; - parameter_0 is "Z"; - parameter_1 is "v"; - reaction_0 is "G protein binding GAP"; - reaction_1 is "G protein binding GTP"; - reaction_2 is "G binding Receptor"; - reaction_3 is "G*T hydrolysis"; - reaction_4 is "GD dissociation"; - reaction_5 is "RG binding GTP"; - reaction_6 is "G*T binding Receptor"; - reaction_7 is "G*T binding GAP"; - reaction_8 is "GD binding GAP"; - reaction_9 is "GD binding Receptor"; - reaction_10 is "RG*T hydrolysis"; - reaction_11 is "RGD dissociation"; - reaction_12 is "GA binding GTP"; - reaction_13 is "G*AT hydrolysis"; - reaction_14 is "GAD dissociation"; - reaction_15 is "RG binding GAP"; - reaction_16 is "GA binding Receptor"; - reaction_17 is "RGA binding GTP"; - reaction_18 is "G*AT binding Receptor"; - reaction_19 is "RG*T binding GAP"; - reaction_20 is "RG*AT hydrolysis"; - reaction_21 is "RGD binding GAP"; - reaction_22 is "GAD binding Receptor"; - reaction_23 is "RGAD dissociation"; - - // CV terms: - compartment_0 hypernym "http://identifiers.org/obo.go/GO:0005623" - species_0 hypernym "http://identifiers.org/interpro/IPR000342" - species_1 identity "http://identifiers.org/obo.go/GO:0005834" - species_2 part "http://identifiers.org/interpro/IPR000342", - "http://identifiers.org/obo.go/GO:0005834" - species_3 identity "http://identifiers.org/obo.chebi/CHEBI:15996", - "http://identifiers.org/kegg.compound/C00044" - species_4 version "http://identifiers.org/interpro/IPR000337" - species_4 hypernym "http://identifiers.org/obo.go/GO:0043235" - species_5 part "http://identifiers.org/obo.chebi/CHEBI:15996", - "http://identifiers.org/obo.go/GO:0005834" - species_6 part "http://identifiers.org/obo.chebi/CHEBI:17552", - "http://identifiers.org/obo.go/GO:0005834" - species_7 identity "http://identifiers.org/obo.chebi/CHEBI:18367" - species_8 identity "http://identifiers.org/obo.chebi/CHEBI:17552", - "http://identifiers.org/kegg.compound/C00035" - species_9 part "http://identifiers.org/obo.go/GO:0043235", - "http://identifiers.org/obo.go/GO:0005834" - species_10 part "http://identifiers.org/obo.chebi/CHEBI:15996", - "http://identifiers.org/obo.go/GO:0043235", - "http://identifiers.org/obo.go/GO:0005834" - species_11 part "http://identifiers.org/obo.chebi/CHEBI:15996", - "http://identifiers.org/interpro/IPR000342", - "http://identifiers.org/obo.go/GO:0005834" - species_12 part "http://identifiers.org/obo.chebi/CHEBI:17552", - "http://identifiers.org/interpro/IPR000342", - "http://identifiers.org/obo.go/GO:0005834" - species_13 part "http://identifiers.org/obo.chebi/CHEBI:17552", - "http://identifiers.org/obo.go/GO:0043235", - "http://identifiers.org/obo.go/GO:0005834" - species_14 part "http://identifiers.org/interpro/IPR000342", - "http://identifiers.org/obo.go/GO:0043235", - "http://identifiers.org/obo.go/GO:0005834" - species_15 part "http://identifiers.org/obo.chebi/CHEBI:15996", - "http://identifiers.org/interpro/IPR000342", - "http://identifiers.org/obo.go/GO:0043235", - "http://identifiers.org/obo.go/GO:0005834" - species_16 part "http://identifiers.org/obo.chebi/CHEBI:17552", - "http://identifiers.org/interpro/IPR000342", - "http://identifiers.org/obo.go/GO:0043235", - "http://identifiers.org/obo.go/GO:0005834" - reaction_0 hypernym "http://identifiers.org/obo.go/GO:0005515" - reaction_1 hypernym "http://identifiers.org/obo.go/GO:0005515", - "http://identifiers.org/obo.go/GO:0005525" - reaction_2 hypernym "http://identifiers.org/obo.go/GO:0001664" - reaction_3 version "http://identifiers.org/reactome/REACT_348" - reaction_3 hypernym "http://identifiers.org/obo.go/GO:0003924" - reaction_4 hypernym "http://identifiers.org/obo.go/GO:0043241" - reaction_5 hypernym "http://identifiers.org/obo.go/GO:0032403", - "http://identifiers.org/obo.go/GO:0005525" - reaction_6 hypernym "http://identifiers.org/obo.go/GO:0005102", - "http://identifiers.org/obo.go/GO:0001664" - reaction_7 hypernym "http://identifiers.org/obo.go/GO:0032403" - reaction_8 hypernym "http://identifiers.org/obo.go/GO:0032403" - reaction_9 hypernym "http://identifiers.org/obo.go/GO:0005102", - "http://identifiers.org/obo.go/GO:0001664" - reaction_10 version "http://identifiers.org/reactome/REACT_348" - reaction_10 hypernym "http://identifiers.org/obo.go/GO:0003924" - reaction_11 hypernym "http://identifiers.org/obo.go/GO:0043241" - reaction_12 hypernym "http://identifiers.org/obo.go/GO:0005525", - "http://identifiers.org/obo.go/GO:0005515" - reaction_13 version "http://identifiers.org/reactome/REACT_348" - reaction_13 hypernym "http://identifiers.org/obo.go/GO:0003924" - reaction_14 hypernym "http://identifiers.org/obo.go/GO:0043241" - reaction_15 hypernym "http://identifiers.org/obo.go/GO:0032403" - reaction_16 hypernym "http://identifiers.org/obo.go/GO:0005102", - "http://identifiers.org/obo.go/GO:0001664" - reaction_17 hypernym "http://identifiers.org/obo.go/GO:0032403", - "http://identifiers.org/obo.go/GO:0005525" - reaction_18 hypernym "http://identifiers.org/obo.go/GO:0001664", - "http://identifiers.org/obo.go/GO:0005102" - reaction_19 hypernym "http://identifiers.org/obo.go/GO:0032403" - reaction_20 hypernym "http://identifiers.org/obo.go/GO:0003924" - reaction_20 version "http://identifiers.org/reactome/REACT_348" - reaction_21 hypernym "http://identifiers.org/obo.go/GO:0032403" - reaction_22 hypernym "http://identifiers.org/obo.go/GO:0001664", - "http://identifiers.org/obo.go/GO:0005102" - reaction_23 hypernym "http://identifiers.org/obo.go/GO:0043241" -end - -Model_0 is "Bornheimer2004_GTPaseCycle" - -Model_0 model_entity_is "http://identifiers.org/biomodels.db/MODEL4822989369" -Model_0 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000086" -Model_0 description "http://identifiers.org/pubmed/15520372" -Model_0 taxon "http://identifiers.org/taxonomy/131567" -Model_0 hypernym "http://identifiers.org/obo.go/GO:0008277" diff --git a/BioModelsRAG/data/BIOMD0000000087.txt b/BioModelsRAG/data/BIOMD0000000087.txt deleted file mode 100644 index d11cf8e208c1a95c7848459f7f35f408c525b331..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000087.txt +++ /dev/null @@ -1,328 +0,0 @@ -// Created by libAntimony v2.13.0 -model *YeastWTmodel2() - - // Compartments and Species: - compartment cellMembrane, nucleus; - substanceOnly species Ctelo in nucleus, Utelo in nucleus, Cdc13 in nucleus; - substanceOnly species Rad17Utelo in nucleus, Rad17 in nucleus, Rad24 in nucleus; - substanceOnly species RPA in nucleus, Mec1 in nucleus, ssDNA in nucleus; - substanceOnly species RPAssDNA in nucleus, RPAssDNA1 in nucleus, RPAssDNA2 in nucleus; - substanceOnly species Mec1RPAssDNA in nucleus, ExoXI in nucleus, ExoXA in nucleus; - substanceOnly species Exo1I in nucleus, Exo1A in nucleus, Rad9I in nucleus; - substanceOnly species Rad9A in nucleus, Rad53I in nucleus, Rad53A in nucleus; - substanceOnly species Chk1I in nucleus, Chk1A in nucleus, Dun1I in nucleus; - substanceOnly species Dun1A in nucleus, ATP in nucleus, ADP in nucleus; - substanceOnly species Rad9Kin in nucleus, recovery in nucleus, G1 in nucleus; - substanceOnly species S in nucleus, G2 in nucleus, M in nucleus, G1cyclin in nucleus; - substanceOnly species Scyclin in nucleus, G2cyclin in nucleus, Mcyclin in nucleus; - substanceOnly species G1CdkI in nucleus, G1CdkA in nucleus, SCdkI in nucleus; - substanceOnly species SCdkA in nucleus, G2CdkI in nucleus, G2CdkA in nucleus; - substanceOnly species MCdkI in nucleus, MCdkA in nucleus, G1Soff in nucleus; - substanceOnly species G1Son in nucleus, SG2off in nucleus, SG2on in nucleus; - substanceOnly species G2Moff in nucleus, G2Mon in nucleus, MG1off in nucleus; - substanceOnly species MG1on in nucleus, $sink in nucleus, budscar in cellMembrane; - - // Reactions: - Capping: Cdc13 + Utelo => Ctelo; Capping_k1*Cdc13*Utelo*kalive; - Uncapping: Ctelo => Cdc13 + Utelo; Uncapping_k2*Ctelo*kalive; - Rad17binding: Utelo + Rad17 + Rad24 + ATP => Rad17Utelo + Rad24 + ADP; Rad17binding_k3*Utelo*Rad17*Rad24*ATP*kalive/(5000 + ATP); - ExoXactivation: ExoXI + Rad17Utelo => ExoXA + Rad17Utelo; ExoXactivation_k4*ExoXI*Rad17Utelo*kalive; - ExoXactivity: ExoXA + Rad17Utelo => ExoXA + Rad17Utelo + ssDNA; ExoXactivity_k5*ExoXA*Rad17Utelo*kalive; - Exo1activation: Exo1I => Exo1A; Exo1activation_k6a*Exo1I*kalive; - Exo1Rad24dependentActivation: Exo1I + Rad24 => Exo1A + Rad24; Exo1Rad24dependentActivation_k6b*Exo1I*Rad24*kalive; - Exo1Rad17independentActivity: Utelo + Exo1A => Utelo + Exo1A + ssDNA; Exo1Rad17independentActivity_k7a*Utelo*Exo1A*kalive; - Exo1Rad17dependentActivity: Rad17Utelo + Exo1A => Rad17Utelo + Exo1A + ssDNA; Exo1Rad17dependentActivity_k7b*Rad17Utelo*Exo1A*kalive; - RPAbinding1: ssDNA + RPA => RPAssDNA1; RPAbinding1_k8a*RPA*ssDNA*kalive; - RPAbinding2: ssDNA + RPAssDNA1 => RPAssDNA2; RPAbinding2_k8b*RPAssDNA1*ssDNA*kalive; - RPAbinding: ssDNA + RPAssDNA2 => RPAssDNA; RPAbinding_k8c*RPAssDNA2*ssDNA*kalive; - Mec1binding: RPAssDNA + Mec1 => Mec1RPAssDNA; Mec1binding_k8d*RPAssDNA*Mec1*kalive; - Rad9activation: Rad9Kin + Rad9I => Rad9Kin + Rad9A; Rad9activation_k9*Rad9Kin*Rad9I*kalive; - ExoXinhibition: ExoXA + Rad9A => ExoXI + Rad9A; ExoXA*ExoXinhibition_k10a*Rad9A*kalive; - ExoXinhibition2: ExoXA + Rad9I => ExoXI + Rad9I; ExoXA*ExoXinhibition2_k10b*Rad9I*kalive; - Rad53activation: Rad53I + Rad9A => Rad53A + Rad9A; Rad53activation_k11*Rad53I*Rad9A*kalive; - Chk1Activation: Chk1I + Rad9A => Chk1A + Rad9A; Chk1I*Chk1Activation_k12*Rad9A*kalive; - Exo1inhibition: Exo1A + Rad53A => Exo1I + Rad53A; Exo1A*Exo1inhibition_k13*Rad53A*kalive; - Dun1activation: Dun1I + Rad53A => Dun1A + Rad53A; Dun1I*Dun1activation_k14*Rad53A*kalive; - Chk1cellArrest: Chk1A + G2Mon => Chk1A + G2Moff; Chk1A*G2Mon*Chk1cellArrest_k15*kalive; - Dun1cellArrest: Dun1A + G2Mon => Dun1A + G2Moff; Dun1A*G2Mon*Dun1cellArrest_k16*kalive; - SDNArepair1: Mec1RPAssDNA + S => Mec1 + RPA + S + 3 ssDNA; SDNArepair1_k17a*Mec1RPAssDNA*S*kalive; - G2DNArepair1: G2 + G2Moff + Mec1RPAssDNA => G2 + G2Moff + Mec1 + RPA + 3 ssDNA; G2*G2Moff*G2DNArepair1_k17b*Mec1RPAssDNA*kalive; - SDNArepair2: S + ssDNA => S; SDNArepair2_k18a*S*ssDNA*kalive; - G2DNArepair2: G2 + G2Moff + ssDNA => G2 + G2Moff; G2*G2Moff*G2DNArepair2_k18b*ssDNA*kalive; - Recovery: Cdc13 + Rad17Utelo + recovery => Ctelo + Rad17 + recovery; Cdc13*Recovery_k19*Rad17Utelo*recovery*kalive; - G1cyclinSynthesis: G1 => G1cyclin + G1; G1*G1cyclinSynthesis_kc1*kalive; - ScyclinSynthesis: S => Scyclin + S; ScyclinSynthesis_kc1*S*kalive; - G2cyclinSynthesis: G2 => G2cyclin + G2; G2*G2cyclinSynthesis_kc1*kalive; - McyclinSynthesis: M => Mcyclin + M; McyclinSynthesis_kc1*M*kalive; - G1toSGenesOn: G1Soff + G1 + G1CdkA => G1Son + G1 + G1CdkA; G1*G1CdkA*G1Soff*G1toSGenesOn_kc2*kalive; - StoG2GenesOn: SG2off + S + SCdkA => SG2on + S + SCdkA; StoG2GenesOn_kc2*S*SCdkA*SG2off*kalive; - G2toMGenesOn: G2Moff + G2 + G2CdkA => G2Mon + G2 + G2CdkA; G2*G2CdkA*G2Moff*G2toMGenesOn_kc2*kalive; - MtoG1GenesOn: MG1off + M + MCdkA => MG1on + M + MCdkA; MtoG1GenesOn_kc2*M*MCdkA*MG1off*kalive; - G1cyclinDegradation: G1cyclin => $sink; G1cyclin*G1cyclinDegradation_kc3*kalive; - ScyclinDegradation: Scyclin => $sink; ScyclinDegradation_kc3*Scyclin*kalive; - G2cyclinDegradation: G2cyclin => $sink; G2cyclin*G2cyclinDegradation_kc3*kalive; - McyclinDegradation: Mcyclin => $sink; McyclinDegradation_kc3*Mcyclin*kalive; - G1toSProgession: G1 + G1CdkA + G1Son => G1CdkI + G1Soff + S; G1*G1CdkA*G1Son*G1toSProgession_kc4*kalive; - StoG2Progession: S + SCdkA + SG2on => G2 + SCdkI + SG2off; StoG2Progession_kc4*S*SCdkA*SG2on*kalive; - G2toMProgession: G2 + G2CdkA + G2Mon => G2CdkI + G2Moff + M; G2*G2CdkA*G2Mon*G2toMProgession_kc4*kalive; - MtoG1Progession: M + MCdkA + MG1on => budscar + G1 + MCdkI + MG1off; MtoG1Progession_kc4*M*MCdkA*MG1on*kalive; - - // Events: - Rad9KinaseActivation: at Mec1RPAssDNA >= 800: Rad9Kin = 1; - ssDNAremoval: at (Mec1RPAssDNA + RPAssDNA + ssDNA) <= 1: ssDNA = 0, RPAssDNA = 0, Mec1RPAssDNA = 0, recovery = 1; - G2MRecoveryCompleted: at (G2 == 1) && (Rad17Utelo == 0): Rad53A = 0, Rad53I = 6900, ExoXI = 70, ExoXA = 0, Exo1I = 670, Exo1A = 0, Dun1I = 3000, Dun1A = 0, Chk1I = 60, Chk1A = 0, Rad9I = 20, Rad9A = 0, recovery = 0, G2Moff = 0, G2Mon = 1; - SphaseRecoveryCompleted: at Rad17Utelo == 0: recovery = 0; - G1CdkActivation: at G1cyclin > 100: G1CdkI = 0, G1CdkA = 1; - SCdkActivation: at Scyclin > 100: SCdkI = 0, SCdkA = 1; - G2CdkActivation: at G2cyclin > 100: G2CdkI = 0, G2CdkA = 1; - MCdkActivation: at Mcyclin > 100: MCdkI = 0, MCdkA = 1; - CellDeath: at (Mec1RPAssDNA + RPAssDNA + ssDNA) >= 2000: kalive = 0; - - // Species initializations: - Ctelo = 64/nucleus; - Utelo = 0; - Cdc13 = 300/nucleus; - Rad17Utelo = 0; - Rad17 = 70/nucleus; - Rad24 = 70/nucleus; - RPA = 4000/nucleus; - Mec1 = 4000/nucleus; - ssDNA = 0; - RPAssDNA = 0; - RPAssDNA1 = 0; - RPAssDNA2 = 0; - Mec1RPAssDNA = 0; - ExoXI = 70/nucleus; - ExoXA = 0; - Exo1I = 670/nucleus; - Exo1A = 0; - Rad9I = 20/nucleus; - Rad9A = 0; - Rad53I = 6900/nucleus; - Rad53A = 0; - Chk1I = 60/nucleus; - Chk1A = 0; - Dun1I = 3000/nucleus; - Dun1A = 0; - ATP = 10000/nucleus; - ADP = 1000/nucleus; - Rad9Kin = 0; - recovery = 0; - G1 = 1/nucleus; - S = 0; - G2 = 0; - M = 0; - G1cyclin = 0; - Scyclin = 0; - G2cyclin = 0; - Mcyclin = 0; - G1CdkI = 1/nucleus; - G1CdkA = 0; - SCdkI = 1/nucleus; - SCdkA = 0; - G2CdkI = 1/nucleus; - G2CdkA = 0; - MCdkI = 1/nucleus; - MCdkA = 0; - G1Soff = 1/nucleus; - G1Son = 0; - SG2off = 1/nucleus; - SG2on = 0; - G2Moff = 1/nucleus; - G2Mon = 0; - MG1off = 1/nucleus; - MG1on = 0; - sink = 0; - budscar = 0; - - // Compartment initializations: - cellMembrane = 1; - nucleus = 1; - - // Variable initializations: - kalive = 1; - Capping_k1 = 0.0005; - Uncapping_k2 = 0.000385; - Rad17binding_k3 = 1.5e-08; - ExoXactivation_k4 = 0.01; - ExoXactivity_k5 = 0.0003; - Exo1activation_k6a = 5e-05; - Exo1Rad24dependentActivation_k6b = 0.0005; - Exo1Rad17independentActivity_k7a = 3e-05; - Exo1Rad17dependentActivity_k7b = 3e-05; - RPAbinding1_k8a = 0.001; - RPAbinding2_k8b = 100; - RPAbinding_k8c = 100; - Mec1binding_k8d = 0.004; - Rad9activation_k9 = 100; - ExoXinhibition_k10a = 0.05; - ExoXinhibition2_k10b = 0.05; - Rad53activation_k11 = 1e-05; - Chk1Activation_k12 = 0.00017; - Exo1inhibition_k13 = 1; - Dun1activation_k14 = 3.3e-06; - Chk1cellArrest_k15 = 0.2; - Dun1cellArrest_k16 = 0.1; - SDNArepair1_k17a = 0.05; - G2DNArepair1_k17b = 0.05; - SDNArepair2_k18a = 0.001; - G2DNArepair2_k18b = 1e-05; - Recovery_k19 = 0.001; - G1cyclinSynthesis_kc1 = 0.16; - ScyclinSynthesis_kc1 = 0.16; - G2cyclinSynthesis_kc1 = 0.16; - McyclinSynthesis_kc1 = 0.16; - G1toSGenesOn_kc2 = 0.01; - StoG2GenesOn_kc2 = 0.01; - G2toMGenesOn_kc2 = 0.01; - MtoG1GenesOn_kc2 = 0.01; - G1cyclinDegradation_kc3 = 0.0012; - ScyclinDegradation_kc3 = 0.0012; - G2cyclinDegradation_kc3 = 0.0012; - McyclinDegradation_kc3 = 0.0012; - G1toSProgession_kc4 = 0.01; - StoG2Progession_kc4 = 0.01; - G2toMProgession_kc4 = 0.01; - MtoG1Progession_kc4 = 0.01; - - // Other declarations: - var kalive; - const cellMembrane, nucleus; - - // Unit definitions: - unit substance = item; - - // Display Names: - Exo1activation is "Rad24independentExo1Activation"; - Exo1Rad24dependentActivation is "Rad24dependentExo1Activation"; - Exo1Rad17independentActivity is "Rad17independentExo1Activity"; - Exo1Rad17dependentActivity is "Rad17dependentExo1Activity"; - RPAbinding1 is "RPAbinding-stage1"; - RPAbinding2 is "RPAbinding-stage2"; - RPAbinding is "RPAbinding-completed"; - - // CV terms: - cellMembrane hypernym "http://identifiers.org/obo.go/GO:0016020" - nucleus hypernym "http://identifiers.org/obo.go/GO:0005634" - Ctelo part "http://identifiers.org/obo.go/GO:0000782" - Ctelo hypernym "http://identifiers.org/obo.go/GO:0000781" - Utelo hypernym "http://identifiers.org/obo.go/GO:0000781" - Cdc13 identity "http://identifiers.org/uniprot/P32797" - Rad17Utelo part "http://identifiers.org/uniprot/P48581", - "http://identifiers.org/obo.go/GO:0000781" - Rad17 identity "http://identifiers.org/uniprot/P48581" - Rad24 identity "http://identifiers.org/uniprot/P32641" - RPA hypernym "http://identifiers.org/pirsf/PIRSF002091" - Mec1 identity "http://identifiers.org/uniprot/P38111" - ssDNA hypernym "http://identifiers.org/obo.chebi/CHEBI:09160", - "http://identifiers.org/kegg.compound/C00271" - RPAssDNA part "http://identifiers.org/kegg.compound/C00271", - "http://identifiers.org/pirsf/PIRSF002091", - "http://identifiers.org/chebi/CHEBI:9160" - RPAssDNA1 part "http://identifiers.org/kegg.compound/C00271", - "http://identifiers.org/pirsf/PIRSF002091", - "http://identifiers.org/chebi/CHEBI:9160" - RPAssDNA2 part "http://identifiers.org/kegg.compound/C00271", - "http://identifiers.org/pirsf/PIRSF002091", - "http://identifiers.org/chebi/CHEBI:9160" - Mec1RPAssDNA part "http://identifiers.org/uniprot/P38111", - "http://identifiers.org/kegg.compound/C00271", - "http://identifiers.org/pirsf/PIRSF002091", - "http://identifiers.org/chebi/CHEBI:9160" - ExoXI homolog "http://identifiers.org/uniprot/P0AEK1" - ExoXA homolog "http://identifiers.org/uniprot/P0AEK1" - Exo1I identity "http://identifiers.org/uniprot/P39875" - Exo1A hypernym "http://identifiers.org/uniprot/P39875" - Rad9I hypernym "http://identifiers.org/uniprot/P14737" - Rad9A identity "http://identifiers.org/uniprot/P14737" - Rad53I identity "http://identifiers.org/uniprot/P22216" - Rad53A hypernym "http://identifiers.org/uniprot/P22216" - Chk1I identity "http://identifiers.org/uniprot/P38147" - Chk1A identity "http://identifiers.org/uniprot/P38147" - Dun1I identity "http://identifiers.org/uniprot/P39009" - Dun1A identity "http://identifiers.org/uniprot/P39009" - ATP identity "http://identifiers.org/obo.chebi/CHEBI:15422" - ADP identity "http://identifiers.org/obo.chebi/CHEBI:16761" - G1 hypernym "http://identifiers.org/obo.go/GO:0051318" - S hypernym "http://identifiers.org/obo.go/GO:0000084" - G2 hypernym "http://identifiers.org/obo.go/GO:0051319" - M hypernym "http://identifiers.org/obo.go/GO:0000279" - G1cyclin version "http://identifiers.org/uniprot/P20437" - Scyclin version "http://identifiers.org/uniprot/P30283" - G2cyclin version "http://identifiers.org/uniprot/P24868" - Mcyclin homolog "http://identifiers.org/uniprot/O14332" - G1CdkI hypernym "http://identifiers.org/obo.go/GO:0019908" - G1CdkA hypernym "http://identifiers.org/obo.go/GO:0019908" - SCdkI hypernym "http://identifiers.org/obo.go/GO:0019908" - SCdkA hypernym "http://identifiers.org/obo.go/GO:0019908" - G2CdkI hypernym "http://identifiers.org/obo.go/GO:0019908" - G2CdkA hypernym "http://identifiers.org/obo.go/GO:0019908" - MCdkI hypernym "http://identifiers.org/obo.go/GO:0019908" - MCdkA hypernym "http://identifiers.org/obo.go/GO:0019908" - G1Soff hypernym "http://identifiers.org/obo.go/GO:0031575" - G1Son hypernym "http://identifiers.org/obo.go/GO:0000082" - SG2off hypernym "http://identifiers.org/obo.go/GO:0000115" - SG2on hypernym "http://identifiers.org/obo.go/GO:0000115" - G2Moff hypernym "http://identifiers.org/obo.go/GO:0031572" - G2Mon hypernym "http://identifiers.org/obo.go/GO:0000086" - MG1on hypernym "http://identifiers.org/obo.go/GO:0000087" - budscar hypernym "http://identifiers.org/obo.go/GO:0005621" - Capping hypernym "http://identifiers.org/obo.go/GO:0016233" - Uncapping hypernym "http://identifiers.org/obo.go/GO:0043241" - Rad17binding hypernym "http://identifiers.org/obo.go/GO:0005515", - "http://identifiers.org/obo.go/GO:0016887" - ExoXactivation hypernym "http://identifiers.org/obo.go/GO:0032075" - ExoXactivity hypernym "http://identifiers.org/obo.go/GO:0008856" - ExoXactivity hypernym "http://identifiers.org/ec-code/3.1.11.1" - Exo1activation hypernym "http://identifiers.org/obo.go/GO:0032075" - Exo1Rad24dependentActivation hypernym "http://identifiers.org/obo.go/GO:0032075" - Exo1Rad17independentActivity hypernym "http://identifiers.org/obo.go/GO:0008856" - Exo1Rad17dependentActivity hypernym "http://identifiers.org/obo.go/GO:0008856" - RPAbinding1 hypernym "http://identifiers.org/obo.go/GO:0003676", - "http://identifiers.org/obo.go/GO:0005515" - RPAbinding2 hypernym "http://identifiers.org/obo.go/GO:0003676", - "http://identifiers.org/obo.go/GO:0032403" - RPAbinding hypernym "http://identifiers.org/obo.go/GO:0003676", - "http://identifiers.org/obo.go/GO:0032403" - Mec1binding hypernym "http://identifiers.org/obo.go/GO:0005515" - Mec1binding hypernym "http://identifiers.org/obo.go/GO:0006461" - Rad9activation hypernym "http://identifiers.org/obo.go/GO:0030295" - ExoXinhibition hypernym "http://identifiers.org/obo.go/GO:0004860" - ExoXinhibition2 hypernym "http://identifiers.org/obo.go/GO:0004860" - Rad53activation hypernym "http://identifiers.org/obo.go/GO:0030295" - Chk1Activation hypernym "http://identifiers.org/obo.go/GO:0030295" - Exo1inhibition hypernym "http://identifiers.org/obo.go/GO:0004860" - Dun1activation hypernym "http://identifiers.org/obo.go/GO:0030295" - Chk1cellArrest hypernym "http://identifiers.org/obo.go/GO:0007050" - Dun1cellArrest hypernym "http://identifiers.org/obo.go/GO:0007050" - SDNArepair1 hypernym "http://identifiers.org/obo.go/GO:0043241" - SDNArepair1 hypernym "http://identifiers.org/obo.go/GO:0006281" - G2DNArepair1 hypernym "http://identifiers.org/obo.go/GO:0043241" - G2DNArepair1 hypernym "http://identifiers.org/obo.go/GO:0006281" - SDNArepair2 hypernym "http://identifiers.org/obo.go/GO:0006308" - G2DNArepair2 hypernym "http://identifiers.org/obo.go/GO:0006308" - Recovery hypernym "http://identifiers.org/obo.go/GO:0005515", - "http://identifiers.org/obo.go/GO:0016233" - G1cyclinSynthesis hypernym "http://identifiers.org/obo.go/GO:0006412" - ScyclinSynthesis hypernym "http://identifiers.org/obo.go/GO:0006412" - G2cyclinSynthesis hypernym "http://identifiers.org/obo.go/GO:0006412" - McyclinSynthesis hypernym "http://identifiers.org/obo.go/GO:0006412" - G1toSGenesOn hypernym "http://identifiers.org/obo.go/GO:0007089" - G2toMGenesOn hypernym "http://identifiers.org/obo.go/GO:0031572" - G1cyclinDegradation hypernym "http://identifiers.org/obo.go/GO:0008054" - ScyclinDegradation hypernym "http://identifiers.org/obo.go/GO:0008054" - G2cyclinDegradation hypernym "http://identifiers.org/obo.go/GO:0008054" - McyclinDegradation hypernym "http://identifiers.org/obo.go/GO:0008054" - G1toSProgession hypernym "http://identifiers.org/obo.go/GO:0000082" - G2toMProgession hypernym "http://identifiers.org/obo.go/GO:0000086" - MtoG1Progession hypernym "http://identifiers.org/obo.go/GO:0000216" -end - -YeastWTmodel2 is "Proctor2006_telomere" - -YeastWTmodel2 model_entity_is "http://identifiers.org/biomodels.db/MODEL8679489165" -YeastWTmodel2 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000087" -YeastWTmodel2 description "http://identifiers.org/pubmed/17015293" -YeastWTmodel2 taxon "http://identifiers.org/taxonomy/4932" -YeastWTmodel2 parthood "http://identifiers.org/kegg.pathway/sce04111" -YeastWTmodel2 hypernym "http://identifiers.org/obo.go/GO:0000075" diff --git a/BioModelsRAG/data/BIOMD0000000088.txt b/BioModelsRAG/data/BIOMD0000000088.txt deleted file mode 100644 index 17b6bdeaa7dae68b9b5c387225d84776ea798f46..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000088.txt +++ /dev/null @@ -1,1373 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Maeda2006_MyosinPhosphorylation() - - // Compartments and Species: - compartment c0, c1, c2; - species $s2 in c0, s174 in c1, s130 in c1, s4 in c0, s57 in c1, s93 in c1; - species s165 in c1, s183 in c1, s55 in c1, s184 in c1, $s48 in c1, s187 in c1; - species $s50 in c1, s171 in c1, s173 in c1, s98 in c1, s124 in c1, s118 in c1; - species s153 in c1, s152 in c1, s213 in c1, s214 in c1, $s151 in c1, s164 in c1; - species s231 in c1, s233 in c1, s245 in c1, s252 in c1, s277 in c1, s278 in c1; - species s279 in c1, s280 in c1, s289 in c1, s292 in c1, s293 in c1, s294 in c1; - species s295 in c1, s309 in c1, s310 in c1, s311 in c1, s314 in c1, s324 in c1; - species s329 in c1, s330 in c1, s331 in c1, s332 in c1, s335 in c1, s338 in c1; - species s352 in c1, s355 in c1, s349 in c1, s360 in c1, s358 in c1, s361 in c1; - species s362 in c1, s350 in c1, s135 in c1, s276 in c1, s172 in c2, s410 in c1; - species s421 in c1, s424 in c1, s430 in c1, s432 in c1, s435 in c1, s436 in c1; - species s437 in c1, s438 in c1, s439 in c1, s440 in c1, s441 in c1, s442 in c1; - species s443 in c1, s444 in c1, s446 in c1, s449 in c1, s456 in c1, s359 in c1; - species s463 in c1, s467 in c1, s470 in c1, s477 in c1, s480 in c1, s491 in c1; - species s487 in c1, s496 in c1, s506 in c1, s512 in c1, s513 in c1, s520 in c1; - species s526 in c1, s539 in c1, s546 in c1, s551 in c1, $s556 in c1, $s267 in c0; - species $s557 in c1, s564 in c1, s565 in c1, s566 in c1, s567 in c1, s568 in c1; - species s569 in c1, s351 in c1, s570 in c1; - - // Reactions: - re1: $s2 + s130 -> s174; c1*((1 + re1_ratio)*re1_Vmax*s130*s2/re1_Km - re1_Vmax*re1_ratio*s174); - re12: $s48 + s435 => s439 + s410 + $s50 + s55; c1*re12_kf*s48*s435; - re14: s55 => s183; c1*re14_kf*s55; - re15: s442 + s57 -> s441; c1*(re15_kf*s442*s57 - re15_kb*s441); - re16: s441 + $s48 => s187 + s55 + $s50 + s421; c1*re16_kf*s48*s441; - re17: s439 => s438; c1*re17_kf*s439; - re19: s410 + s438 => s437; c1*re19_kf*s410*s438; - re20: s93 + s187 -> s184; c1*((1 + re20_ratio)*re20_Vmax*s187*s93/re20_Km - re20_ratio*re20_Vmax*s184); - re22: s421 + s440 => s442; c1*re22_kf*s421*s440; - re23: s439 + s98 -> s436; c1*(re23_kf*s439*s98 - re23_kb*s436); - re24: s231 => s214; c1*(re24_Vmax*s231*s436/(re24_Km + s214)); - re26: s98 + s231 -> s233; c1*((1 + re26_ratio)*re26_Vmax*s98*s231/re26_Km - re26_Vmax*re26_ratio*s233); - re28: s118 + s214 -> s213; c1*((1 + re28_ratio)*re28_Vmax*s118*s214/re28_Km - re28_Vmax*re28_ratio*s213); - re32: s233 => s214 + s98; c1*re32_Vmax*s233; - re33: s213 => s231 + s118; c1*re33_Vmax*s213; - re34: s184 => s440 + s93; c1*re34_Vmax*s184; - re37: s436 => s438 + s98; c1*re37_kf*s436; - re38: s214 => s231; c1*re38_kf*s214; - re39: s124 + s214 -> s252; c1*(re39_kf*s124*s214 - re39_kb*s252); - re40: s174 => s57 + s4 + $s2; c1*re40_Vmax*s174; - re43: s437 + s57 -> s435; c1*(re43_kf*s437*s57 - re43_kb*s435); - re44: s187 => s440; c1*re44_kf*s187; - re45: s57 => s183; c1*re45_kf*s57; - re47: s187 + s569 -> s564; c1*(re47_kf*s187*s569 - re47_kb*s564); - re48: s424 + s187 -> s443; c1*(re48_kf*s424*s187 - re48_kb*s443); - re51: s135 + s443 -> s564; c1*(re51_kf*s135*s443 - re51_kb*s564); - re52: s424 + s135 -> s569; c1*(re52_kf*s424*s135 - re52_kb*s569); - re54: s564 => s569 + s440; c1*re54_kf*s564; - re55: s569 + $s151 -> s568; c1*((1 + re55_ratio)*re55_Vmax*s569*s151/re55_Km - re55_ratio*re55_Vmax*s568); - re56: s564 + $s151 -> s567; c1*((1 + re56_ratio)*re56_Vmax*s564*s151/re56_Km - re56_ratio*re56_Vmax*s567); - re57: s568 => s152 + s153 + s569; c1*re57_Vmax*s568; - re58: s567 => s153 + s152 + s564; c1*re58_Vmax*s567; - re59: s153 => s164; c1*re59_kf*s153; - re60: s152 => s165; c1*re60_kf*s152; - re68: s171 + 3 s152 -> s173; c1*(re68_kf*s152*s152*s152*s171 - re68_kb*s173); - re73: s172 -> s135; c1*re73_g*s173*(s172 - s135); - re85: s444 => 2 s172 + s430; c1*re85_kf*s444; - re86: s276 + s135 -> s277; c1*(re86_kf*s276*s135 - re86_kb*s277); - re87: s277 + s135 -> s278; c1*(re87_kf*s277*s135 - re87_kb*s278); - re88: s279 + s135 -> s280; c1*(re88_kf*s279*s135 - re88_kb*s280); - re89: s278 + s135 -> s279; c1*(re89_kf*s278*s135 - re89_kb*s279); - re90: s280 + s289 -> s295; c1*(re90_kf*s280*s289 - re90_kb*s295); - re91: s279 + s289 -> s294; c1*(re91_kf*s279*s289 - re91_kb*s294); - re92: s278 + s289 -> s293; c1*(re92_kf*s278*s289 - re92_kb*s293); - re93: s277 + s289 -> s292; c1*(re93_kf*s277*s289 - re93_kb*s292); - re94: s309 -> s310; c1*(re94_kf*s309 - re94_kb*s310); - re95: s309 + s153 -> s311; c1*(re95_kf*s309*s153 - re95_kb*s311); - re96: s566 -> s314; c1*(re96_kf*s566 - re96_kb*s314); - re97: s309 + s135 -> s566; c1*(re97_kf*s309*s135 - re97_kb*s566); - re98: s446 => s432 + $s267; c1*re98_Vmax*s446; - re100: s430 + 2 s135 -> s444; c1*(re100_kf*s135*s135*s430 - re100_kb*s444); - re101: s566 + s153 -> s565; c1*(re101_kf*s566*s153 - re101_kb*s565); - re102: s565 -> s324; c1*(re102_kf*s565 - re102_kb*s324); - re106: s324 => s329; c1*re106_kf*s324; - re107: s314 => s330; c1*re107_kf*s314; - re108: s310 => s331; c1*re108_kf*s310; - re109: s432 + s135 -> s446; c1*((1 + re109_ratio)*re109_Vmax*s432*s135/re109_Km - re109_Vmax*re109_ratio*s446); - re110: s324 + s349 -> s338; c1*((1 + re110_ratio)*re110_Vmax*s324*s349/re110_Km - re110_Vmax*re110_ratio*s338); - re111: s314 + s349 -> s335; c1*((1 + re111_ratio)*re111_Vmax*s314*s349/re111_Km - re111_ratio*re111_Vmax*s335); - re112: s310 + s349 -> s332; c1*((1 + re112_ratio)*re112_Vmax*s310*s349/re112_Km - re112_Vmax*re112_ratio*s332); - re113: s338 => s324 + s350; c1*re113_Vmax*s338; - re114: s335 => s314 + s350; c1*re114_Vmax*s335; - re115: s332 => s310 + s350; c1*re115_Vmax*s332; - re116: s350 => s349; c1*re116_kf*s350; - re117: s351 + s350 -> s352; c1*(re117_kf*s351*s350 - re117_kb*s352); - re118: s351 + s349 -> s355; c1*(re118_kf*s351*s349 - re118_kb*s355); - re119: s352 => s355; c1*re119_kf*s352; - re120: s124 + s358 -> s361; c1*((1 + re120_ratio)*re120_Vmax*s124*s358/re120_Km - re120_Vmax*re120_ratio*s361); - re121: s124 + s359 -> s362; c1*((1 + re121_ratio)*re121_Vmax*s124*s359/re121_Km - re121_Vmax*re121_ratio*s362); - re123: s361 => s359 + s124; c1*re123_Vmax*s361; - re124: s362 => s360 + s124; c1*re124_Vmax*s362; - re125: s252 + s358 -> s456; c1*((1 + re125_ratio)*re125_Vmax*s252*s358/re125_Km - re125_Vmax*re125_ratio*s456); - re126: s252 + s359 => s449; c1*((1 + re126_ratio)*re126_Vmax*s252*s359/re126_Km - re126_Vmax*re126_ratio*s449); - re127: s456 => s252 + s359; c1*re127_Vmax*s456; - re128: s449 => s252 + s360; c1*re128_Vmax*s449; - re129: s124 + s351 -> s463; c1*((1 + re129_ratio)*re129_Vmax*s124*s351/re129_Km - re129_Vmax*re129_ratio*s463); - re130: s463 => s124 + s570; c1*re130_Vmax*s463; - re131: s252 + s351 -> s496; c1*((1 + re131_ratio)*re131_Vmax*s252*s351/re131_Km - re131_Vmax*re131_ratio*s496); - re132: s496 => s252 + s570; c1*re132_Vmax*s496; - re133: s360 + s570 -> s467; c1*((1 + re133_ratio)*re133_Vmax*s360*s570/re133_Km - re133_Vmax*re133_ratio*s467); - re134: s360 + s351 -> s470; c1*((1 + re134_ratio)*re134_Vmax*s360*s351/re134_Km - re134_Vmax*re134_ratio*s470); - re135: s359 + s570 -> s477; c1*((1 + re135_ratio)*re135_Vmax*s359*s570/re135_Km - re135_Vmax*re135_ratio*s477); - re136: s359 + s351 -> s480; c1*((1 + re136_ratio)*re136_Vmax*s351*s359/re136_Km - re136_Vmax*re136_ratio*s480); - re137: s467 => s359 + s570; c1*re137_Vmax*s467; - re138: s470 => s359 + s351; c1*re138_Vmax*s470; - re139: s477 => s358 + s570; c1*re139_Vmax*s477; - re140: s480 => s358 + s351; c1*re140_Vmax*s480; - re141: s570 => s351; c1*re141_kf*s570; - re154: s358 + s289 -> s487; c1*((1 + re154_ratio)*re154_Vmax*s289*s358/re154_Km - re154_Vmax*re154_ratio*s487); - re155: s359 + s289 -> s491; c1*((1 + re155_ratio)*re155_Vmax*s289*s359/re155_Km - re155_Vmax*re155_ratio*s491); - re156: s487 => s359 + s289; c1*re156_Vmax*s487; - re157: s491 => s360 + s289; c1*re157_Vmax*s491; - re158: s358 + s292 -> s551; c1*((1 + re158_ratio)*re158_Vmax*s292*s358/re158_Km - re158_Vmax*re158_ratio*s551); - re159: s358 + s293 -> s539; c1*((1 + re159_ratio)*re159_Vmax*s293*s358/re159_Km - re159_Vmax*re159_ratio*s539); - re160: s358 + s294 -> s520; c1*((1 + re160_ratio)*re160_Vmax*s294*s358/re160_Km - re160_Vmax*re160_ratio*s520); - re161: s358 + s295 -> s513; c1*((1 + re161_ratio)*re161_Vmax*s295*s358/re161_Km - re161_Vmax*re161_ratio*s513); - re162: s359 + s292 -> s546; c1*((1 + re162_ratio)*re162_Vmax*s292*s359/re162_Km - re162_Vmax*re162_ratio*s546); - re163: s359 + s293 -> s526; c1*((1 + re163_ratio)*re163_Vmax*s293*s359/re163_Km - re163_Vmax*re163_ratio*s526); - re164: s359 + s294 -> s512; c1*((1 + re164_ratio)*re164_Vmax*s294*s359/re164_Km - re164_Vmax*re164_ratio*s512); - re165: s359 + s295 -> s506; c1*((1 + re165_ratio)*re165_Vmax*s295*s359/re165_Km - re165_Vmax*re165_ratio*s506); - re166: s506 => s360 + s295; c1*re166_Vmax*s506; - re167: s513 => s359 + s295; c1*re167_Vmax*s513; - re168: s512 => s360 + s294; c1*re168_Vmax*s512; - re169: s520 => s359 + s294; c1*re169_Vmax*s520; - re170: s526 => s360 + s293; c1*re170_Vmax*s526; - re171: s539 => s359 + s293; c1*re171_Vmax*s539; - re172: s546 => s360 + s292; c1*re172_Vmax*s546; - re173: s551 => s359 + s292; c1*re173_Vmax*s551; - re174: $s267 -> s135; c1*re174_g*s556*(s267 - s135); - re175: s172 -> s135; c1*re175_g*s557*(s172 - s135); - - // Events: - event_0000001: at time >= 300: s2 = 0.01; - - // Species initializations: - s2 = 0; - s174 = 0; - s130 = 0.42; - s4 = 0; - s57 = 0; - s93 = 0.2; - s165 = 0; - s183 = 0; - s55 = 0; - s184 = 0; - s48 = 50; - s187 = 0; - s50 = 5; - s171 = 0.008333; - s173 = 0; - s98 = 0.1; - s124 = 0.042; - s118 = 0.1; - s153 = 0; - s152 = 0.3; - s213 = 0; - s214 = 0.005; - s151 = 10; - s164 = 0; - s231 = 0.09; - s233 = 0; - s245 = 0; - s252 = 0.005; - s277 = 0.3; - s278 = 0; - s279 = 0; - s280 = 0; - s289 = 0.69; - s292 = 0.05; - s293 = 0; - s294 = 0; - s295 = 0; - s309 = 2; - s310 = 0.039823; - s311 = 0; - s314 = 0.68193; - s324 = 0; - s329 = 0; - s330 = 0; - s331 = 0; - s332 = 0; - s335 = 0; - s338 = 0; - s352 = 0; - s355 = 0; - s349 = 0.059; - s360 = 0.1; - s358 = 4.3; - s361 = 0; - s362 = 0; - s350 = 0; - s135 = 0.0833; - s276 = 19.65; - s172 = 155; - s410 = 0; - s421 = 0; - s424 = 0.57; - s430 = 0.5; - s432 = 0.1; - s435 = 0; - s436 = 0; - s437 = 0.5; - s438 = 0; - s439 = 0; - s440 = 0; - s441 = 0; - s442 = 0.5; - s443 = 0; - s444 = 0; - s446 = 0; - s449 = 0; - s456 = 0; - s359 = 0.6; - s463 = 0; - s467 = 0; - s470 = 0; - s477 = 0; - s480 = 0; - s491 = 0; - s487 = 0; - s496 = 0; - s506 = 0; - s512 = 0; - s513 = 0; - s520 = 0; - s526 = 0; - s539 = 0; - s546 = 0; - s551 = 0; - s556 = 0.00833; - s267 = 4000; - s557 = 0.001; - s564 = 0; - s565 = 0; - s566 = 0.094; - s567 = 0; - s568 = 0.08; - s569 = 0.15; - s351 = 0.7; - s570 = 0.4941; - - // Compartment initializations: - c0 = 1; - c1 = 1; - c2 = 0.1; - - // Variable initializations: - re1_Km = 5; - re1_Km has microMolar; - re1_ratio = 4; - re1_ratio has dimensionless; - re1_Vmax = 15; - re1_Vmax has per_sec; - re12_kf = 0.01; - re12_kf has per_uM_per_sec; - re14_kf = 0.00224; - re14_kf has per_sec; - re15_kf = 1; - re15_kf has per_uM_per_sec; - re15_kb = 0.006; - re15_kb has per_sec; - re16_kf = 0.01; - re16_kf has per_uM_per_sec; - re17_kf = 0.0133; - re17_kf has per_sec; - re19_kf = 0.01; - re19_kf has per_uM_per_sec; - re20_Km = 0.05; - re20_Km has microMolar; - re20_ratio = 23.51; - re20_ratio has dimensionless; - re20_Vmax = 0.0102; - re20_Vmax has per_sec; - re22_kf = 0.01; - re22_kf has per_uM_per_sec; - re23_kf = 20; - re23_kf has per_uM_per_sec; - re23_kb = 0.1; - re23_kb has per_sec; - re24_Km = 0.015; - re24_Km has microMolar; - re24_Vmax = 0.052; - re24_Vmax has per_sec; - re26_Km = 2; - re26_Km has microMolar; - re26_ratio = 4; - re26_ratio has dimensionless; - re26_Vmax = 0.04; - re26_Vmax has per_sec; - re28_Km = 2.83; - re28_Km has microMolar; - re28_ratio = 13.246; - re28_ratio has dimensionless; - re28_Vmax = 0.993; - re28_Vmax has per_sec; - re32_Vmax = 0.04; - re32_Vmax has per_sec; - re33_Vmax = 0.9933; - re33_Vmax has per_sec; - re34_Vmax = 0.0102; - re34_Vmax has per_sec; - re37_kf = 0.0117; - re37_kf has per_sec; - re38_kf = 0.0003667; - re38_kf has per_sec; - re39_kf = 10; - re39_kf has per_uM_per_sec; - re39_kb = 0.5; - re39_kb has per_sec; - re40_Vmax = 15; - re40_Vmax has per_sec; - re43_kf = 1; - re43_kf has per_uM_per_sec; - re43_kb = 0.006; - re43_kb has per_sec; - re44_kf = 0.0133; - re44_kf has per_sec; - re45_kf = 0.00224; - re45_kf has per_sec; - re47_kf = 25.201; - re47_kf has per_uM_per_sec; - re47_kb = 1; - re47_kb has per_sec; - re48_kf = 2.5201; - re48_kf has per_uM_per_sec; - re48_kb = 1; - re48_kb has per_sec; - re51_kf = 30; - re51_kf has per_uM_per_sec; - re51_kb = 1; - re51_kb has per_sec; - re52_kf = 3; - re52_kf has per_uM_per_sec; - re52_kb = 1; - re52_kb has per_sec; - re54_kf = 0.0133; - re54_kf has per_sec; - re55_Km = 19.841; - re55_Km has microMolar; - re55_ratio = 4; - re55_ratio has dimensionless; - re55_Vmax = 10; - re55_Vmax has per_sec; - re56_Km = 5; - re56_Km has microMolar; - re56_ratio = 4; - re56_ratio has dimensionless; - re56_Vmax = 48; - re56_Vmax has per_sec; - re57_Vmax = 10; - re57_Vmax has per_sec; - re58_Vmax = 48; - re58_Vmax has per_sec; - re59_kf = 0.15; - re59_kf has per_sec; - re60_kf = 2.5; - re60_kf has per_sec; - re68_kf = 0.1; - re68_kf has per_uM3_per_sec; - re68_kb = 10; - re68_kb has per_sec; - re73_g = 150; - re73_g has per_uM_per_sec; - re85_kf = 1; - re85_kf has per_sec; - re86_kf = 10; - re86_kf has per_uM_per_sec; - re86_kb = 50; - re86_kb has per_sec; - re87_kf = 10; - re87_kf has per_uM_per_sec; - re87_kb = 45; - re87_kb has per_sec; - re88_kf = 10; - re88_kf has per_uM_per_sec; - re88_kb = 500; - re88_kb has per_sec; - re89_kf = 10; - re89_kf has per_uM_per_sec; - re89_kb = 170; - re89_kb has per_sec; - re90_kf = 10; - re90_kf has per_uM_per_sec; - re90_kb = 0.01; - re90_kb has per_sec; - re91_kf = 10; - re91_kf has per_uM_per_sec; - re91_kb = 0.01; - re91_kb has per_sec; - re92_kf = 0.1; - re92_kf has per_uM_per_sec; - re92_kb = 0.45; - re92_kb has per_sec; - re93_kf = 0.1; - re93_kf has per_uM_per_sec; - re93_kb = 0.5; - re93_kb has per_sec; - re94_kf = 1; - re94_kf has per_sec; - re94_kb = 50; - re94_kb has per_sec; - re95_kf = 0.0003; - re95_kf has per_uM_per_sec; - re95_kb = 0.1; - re95_kb has per_sec; - re96_kf = 1.2705; - re96_kf has per_sec; - re96_kb = 3.5026; - re96_kb has per_sec; - re97_kf = 0.3; - re97_kf has per_uM_per_sec; - re97_kb = 0.5; - re97_kb has per_sec; - re98_Vmax = 4.9; - re98_Vmax has per_sec; - re100_kf = 30; - re100_kf has per_uM2_per_sec; - re100_kb = 3; - re100_kb has per_sec; - re101_kf = 0.004; - re101_kf has per_uM_per_sec; - re101_kb = 8.6348; - re101_kb has per_sec; - re102_kf = 1; - re102_kf has per_sec; - re102_kb = 0.1; - re102_kb has per_sec; - re106_kf = 4.63e-05; - re106_kf has per_sec; - re107_kf = 4.63e-05; - re107_kf has per_sec; - re108_kf = 4.63e-05; - re108_kf has per_sec; - re109_Km = 0.04; - re109_Km has microMolar; - re109_ratio = 4; - re109_ratio has dimensionless; - re109_Vmax = 4.9; - re109_Vmax has per_sec; - re110_Km = 0.0014; - re110_Km has microMolar; - re110_ratio = 4; - re110_ratio has dimensionless; - re110_Vmax = 3.94; - re110_Vmax has per_sec; - re111_Km = 0.0014; - re111_Km has microMolar; - re111_ratio = 4; - re111_ratio has dimensionless; - re111_Vmax = 3.94; - re111_Vmax has per_sec; - re112_Km = 0.0014; - re112_Km has microMolar; - re112_ratio = 4; - re112_ratio has dimensionless; - re112_Vmax = 3.94; - re112_Vmax has per_sec; - re113_Vmax = 3.94; - re113_Vmax has per_sec; - re114_Vmax = 3.94; - re114_Vmax has per_sec; - re115_Vmax = 3.94; - re115_Vmax has per_sec; - re116_kf = 0.5; - re116_kf has per_sec; - re117_kf = 100; - re117_kf has per_uM_per_sec; - re117_kb = 0.62; - re117_kb has per_sec; - re118_kf = 0.01; - re118_kf has per_uM_per_sec; - re118_kb = 0.1; - re118_kb has per_sec; - re119_kf = 0.5; - re119_kf has per_sec; - re120_Km = 4.5099; - re120_Km has microMolar; - re120_ratio = 16.617; - re120_ratio has dimensionless; - re120_Vmax = 1.28; - re120_Vmax has per_sec; - re121_Km = 4.5099; - re121_Km has microMolar; - re121_ratio = 16.617; - re121_ratio has dimensionless; - re121_Vmax = 1.28; - re121_Vmax has per_sec; - re123_Vmax = 1.28; - re123_Vmax has per_sec; - re124_Vmax = 1.28; - re124_Vmax has per_sec; - re125_Km = 2.47; - re125_Km has microMolar; - re125_ratio = 0.4261; - re125_ratio has dimensionless; - re125_Vmax = 8.66; - re125_Vmax has per_sec; - re126_Km = 2.47; - re126_Km has microMolar; - re126_ratio = 0.4261; - re126_ratio has dimensionless; - re126_Vmax = 8.66; - re126_Vmax has per_sec; - re127_Vmax = 8.66; - re127_Vmax has per_sec; - re128_Vmax = 8.66; - re128_Vmax has per_sec; - re129_Km = 0.18; - re129_Km has microMolar; - re129_ratio = 0.23288; - re129_ratio has dimensionless; - re129_Vmax = 1.46; - re129_Vmax has per_sec; - re130_Vmax = 1.46; - re130_Vmax has per_sec; - re131_Km = 0.1; - re131_Km has microMolar; - re131_ratio = 0.028278; - re131_ratio has dimensionless; - re131_Vmax = 17.505; - re131_Vmax has per_sec; - re132_Vmax = 17.505; - re132_Vmax has per_sec; - re133_Km = 58.099; - re133_Km has microMolar; - re133_ratio = 28.795; - re133_ratio has dimensionless; - re133_Vmax = 1.95; - re133_Vmax has per_sec; - re134_Km = 16; - re134_Km has microMolar; - re134_ratio = 7.5865; - re134_ratio has dimensionless; - re134_Vmax = 9.317; - re134_Vmax has per_sec; - re135_Km = 58.099; - re135_Km has microMolar; - re135_ratio = 28.795; - re135_ratio has dimensionless; - re135_Vmax = 1.95; - re135_Vmax has per_sec; - re136_Km = 16; - re136_Km has microMolar; - re136_ratio = 7.5865; - re136_ratio has dimensionless; - re136_Vmax = 9.317; - re136_Vmax has per_sec; - re137_Vmax = 1.95; - re137_Vmax has per_sec; - re138_Vmax = 9.317; - re138_Vmax has per_sec; - re139_Vmax = 1.95; - re139_Vmax has per_sec; - re140_Vmax = 9.317; - re140_Vmax has per_sec; - re141_kf = 0.2; - re141_kf has per_sec; - re154_Km = 148.08; - re154_Km has microMolar; - re154_ratio = 39.349; - re154_ratio has dimensionless; - re154_Vmax = 3.67; - re154_Vmax has per_sec; - re155_Km = 148.08; - re155_Km has microMolar; - re155_ratio = 39.349; - re155_ratio has dimensionless; - re155_Vmax = 3.67; - re155_Vmax has per_sec; - re156_Vmax = 3.67; - re156_Vmax has per_sec; - re157_Vmax = 3.67; - re157_Vmax has per_sec; - re158_Km = 10.019; - re158_Km has microMolar; - re158_ratio = 1.7299; - re158_ratio has dimensionless; - re158_Vmax = 3.67; - re158_Vmax has per_sec; - re159_Km = 10.019; - re159_Km has microMolar; - re159_ratio = 1.7299; - re159_ratio has dimensionless; - re159_Vmax = 3.67; - re159_Vmax has per_sec; - re160_Km = 10.019; - re160_Km has microMolar; - re160_ratio = 1.7299; - re160_ratio has dimensionless; - re160_Vmax = 3.67; - re160_Vmax has per_sec; - re161_Km = 10.019; - re161_Km has microMolar; - re161_ratio = 1.7299; - re161_ratio has dimensionless; - re161_Vmax = 3.67; - re161_Vmax has per_sec; - re162_Km = 10.019; - re162_Km has microMolar; - re162_ratio = 1.7299; - re162_ratio has dimensionless; - re162_Vmax = 3.67; - re162_Vmax has per_sec; - re163_Km = 10.019; - re163_Km has microMolar; - re163_ratio = 1.7299; - re163_ratio has dimensionless; - re163_Vmax = 3.67; - re163_Vmax has per_sec; - re164_Km = 10.019; - re164_Km has microMolar; - re164_ratio = 1.7299; - re164_ratio has dimensionless; - re164_Vmax = 3.67; - re164_Vmax has per_sec; - re165_Km = 10.019; - re165_Km has microMolar; - re165_ratio = 1.7299; - re165_ratio has dimensionless; - re165_Vmax = 3.67; - re165_Vmax has per_sec; - re166_Vmax = 3.67; - re166_Vmax has per_sec; - re167_Vmax = 3.67; - re167_Vmax has per_sec; - re168_Vmax = 3.67; - re168_Vmax has per_sec; - re169_Vmax = 3.67; - re169_Vmax has per_sec; - re170_Vmax = 3.67; - re170_Vmax has per_sec; - re171_Vmax = 3.67; - re171_Vmax has per_sec; - re172_Vmax = 3.67; - re172_Vmax has per_sec; - re173_Vmax = 3.67; - re173_Vmax has per_sec; - re174_g = 0.01; - re174_g has per_uM_per_sec; - re175_g = 0.01; - re175_g has per_uM_per_sec; - - // Other declarations: - const c0, c1, c2; - - // Unit definitions: - unit substance = 1e-6 mole; - unit microMolar = 1e-6 mole / litre; - unit per_uM_per_sec = litre / (1e-6 mole * second); - unit per_sec = 1 / second; - unit per_uM2_per_sec = litre^2 / ((1e-6 mole)^2 * second); - unit per_uM3_per_sec = litre^3 / ((1e-6 mole)^3 * second); - - // Display Names: - substance is "micromoles"; - c0 is "Default"; - c1 is "cytosol"; - c2 is "ER"; - s2 is "thrombin"; - s174 is "thrombin_R"; - s130 is "pro_thrombinR"; - s4 is "thrombin_ligand"; - s57 is "thrombinR active"; - s93 is "RGS"; - s165 is "Inositol"; - s183 is "sa40_degraded"; - s55 is "thrombinR"; - s184 is "RGS"; - s48 is "GTP"; - s187 is "G_sub_q_endsub__alpha_.GTP"; - s50 is "GDP"; - s171 is "IP3R"; - s173 is "3IP3.IP3R"; - s98 is "p115RhoGEF"; - s124 is "Rho-kinase"; - s118 is "RhoGAP"; - s153 is "DAG"; - s152 is "IP3"; - s213 is "Rho_GAP"; - s214 is "Rho.GTP"; - s151 is "PIP2"; - s164 is "PC"; - s231 is "Rho.GDP"; - s233 is "Rho_GEF"; - s245 is "Rho_GEF_active"; - s252 is "Rho.GTP.Rho-kinase"; - s277 is "Ca_super_2_plus__endsuper_.CaM"; - s278 is "2Ca_super_2_plus__endsuper_.CaM"; - s279 is "3Ca_super_2_plus__endsuper_.CaM"; - s280 is "4Ca_super_2_plus__endsuper_.CaM"; - s289 is "MLCK"; - s292 is "MLCK.Ca_super_2_plus__endsuper_.CaM"; - s293 is "MLCK.2Ca_super_2_plus__endsuper_.CaM"; - s294 is "MLCK.3Ca_super_2_plus__endsuper_.CaM"; - s295 is "MLCK.4Ca_super_2_plus__endsuper_.CaM"; - s309 is "PKC"; - s310 is "PKC active1"; - s311 is "PKC.DAG"; - s314 is "PKC active_2"; - s324 is "PKC active_3"; - s329 is "csa39_degraded"; - s330 is "csa36_degraded"; - s331 is "csa35_degraded"; - s332 is "PKC active_1.CPI"; - s335 is "PKC active_2.CPI"; - s338 is "PKC active_3.CPI"; - s352 is "CPI-17.MYPT1_PPase"; - s355 is "CPI-17.MYPT1_PPase"; - s349 is "CPI-17"; - s360 is "MLC"; - s358 is "MLC"; - s361 is "Rho-kinase.MLC"; - s362 is "Rho-kinase.MLC"; - s350 is "CPI-17"; - s135 is "Ca_super_2_plus__endsuper_"; - s276 is "CaM"; - s172 is "Ca_super_2_plus__endsuper_ store"; - s410 is "G_beta__gamma__1"; - s421 is "G_beta__gamma__2"; - s424 is "PLC_beta_"; - s430 is "Ca_super_2_plus__endsuper_ trunsp"; - s432 is "Ca_super_2_plus__endsuper_ pump"; - s435 is "G_sub_12_endsub__alpha__beta__gamma__thrombinR active"; - s436 is "p115RhoGEF.GTP_alpha_"; - s437 is "G_sub_12_endsub__alpha__beta__gamma_"; - s438 is "G_sub_12_endsub__alpha_.GDP"; - s439 is "G_sub_12_endsub__alpha_.GTP"; - s440 is "G_sub_q_endsub__alpha_.GDP"; - s441 is "G_sub_q_endsub__alpha__beta__gamma__thrombinR active"; - s442 is "G_sub_q_endsub__alpha__beta__gamma_"; - s443 is "PLC_beta_.G_sub_q_endsub__alpha_.GTP"; - s444 is "2Ca_super_2_plus__endsuper_ .Ca_super_2_plus__endsuper_ trunsp"; - s446 is "Ca_super_2_plus__endsuper_ pump.Ca_super_2_plus__endsuper_"; - s449 is "Rho.GTP.Rho-kinase.MLC"; - s456 is "Rho.GTP.Rho-kinase.MLC"; - s359 is "MLC"; - s463 is "MYPT1.Rho-kinase"; - s467 is "MYPT1.MLC"; - s470 is "MYPT1.MLC"; - s477 is "MYPT1.MLC"; - s480 is "MYPT1.MLC"; - s491 is "MLCK.MLC"; - s487 is "MLCK.MLC"; - s496 is "MYPT1.Rho-kinase"; - s506 is "MLCK.4Ca_super_2_plus__endsuper_.CaM.MLC"; - s512 is "MLCK.3Ca_super_2_plus__endsuper_.CaM.MLC"; - s513 is "MLCK.4Ca_super_2_plus__endsuper_.CaM.MLC"; - s520 is "MLCK.3Ca_super_2_plus__endsuper_.CaM.MLC"; - s526 is "MLCK.2Ca_super_2_plus__endsuper_.CaM.MLC"; - s539 is "MLCK.2Ca_super_2_plus__endsuper_.CaM.MLC"; - s546 is "MLCK.Ca_super_2_plus__endsuper_.CaM.MLC"; - s551 is "MLCK.Ca_super_2_plus__endsuper_.CaM.MLC"; - s556 is "Ca_super_2_plus__endsuper_ ext leak"; - s267 is "Ca_super_2_plus__endsuper_ ext"; - s557 is "Ca_super_2_plus__endsuper_ int leak"; - s564 is "PLC_beta_.G_sub_q_endsub__alpha_.GTP.Ca_super_2_plus__endsuper_"; - s565 is "PKC.Ca_super_2_plus__endsuper_.DAG"; - s566 is "PKC.Ca_super_2_plus__endsuper_"; - s567 is "PLC_beta_.G_sub_q_endsub_.GTP.Ca.PIP2"; - s568 is "PLC_beta_.Ca.PIP2"; - s569 is "PLC_beta_.Ca_super_2_plus__endsuper_"; - s351 is "MYPT1_PPase"; - s570 is "MYPT1_PPase"; - re1 is "A2-1.1"; - re12 is "A1-2"; - re14 is "A1-5.1"; - re15 is "A1-3"; - re16 is "A1-4"; - re17 is "A1-6"; - re19 is "A1-7"; - re20 is "A2-2.1"; - re22 is "A1-9"; - re23 is "B1-1"; - re24 is "B2-1.1"; - re26 is "B2-2.1"; - re28 is "B2-3.1"; - re32 is "B2-1.2"; - re33 is "B2-3.2"; - re34 is "A2-2.2"; - re37 is "B1-2"; - re38 is "B1-3"; - re39 is "B1-4"; - re40 is "A2-1.2"; - re43 is "A1-1"; - re44 is "A1-8"; - re45 is "A1-5.2"; - re47 is "C1-2"; - re48 is "C1-3"; - re51 is "C1-4"; - re52 is "C1-1"; - re54 is "C1-5"; - re55 is "C2-1.1"; - re56 is "C2-2.1"; - re57 is "C2-1.2"; - re58 is "C2-2.2"; - re59 is "C1-6"; - re60 is "C1-7"; - re68 is "C1-8"; - re73 is "D3-1"; - re85 is "D1-2"; - re86 is "D1-3"; - re87 is "D1-4"; - re88 is "D1-6"; - re89 is "D1-5"; - re90 is "D1-10"; - re91 is "D1-9"; - re92 is "D1-8"; - re93 is "D1-7"; - re94 is "E1-1"; - re95 is "E1-3"; - re96 is "E1-5"; - re97 is "E1-4"; - re98 is "D2-1.2"; - re100 is "D1-1"; - re101 is "E1-7"; - re102 is "E1-8"; - re106 is "E1-9"; - re107 is "E1-6"; - re108 is "E1-2"; - re109 is "D2-1.1"; - re110 is "E2-1.1.3"; - re111 is "E2-1.1.2"; - re112 is "E2-1.1.1"; - re113 is "E2-1.2.3"; - re114 is "E2-1.2.2"; - re115 is "E2-1.2.1"; - re116 is "E1-10"; - re117 is "E1-11"; - re118 is "E1-12"; - re119 is "E1-13"; - re120 is "F2-1.1"; - re121 is "F2-2.1"; - re123 is "F2-1.2"; - re124 is "F2-2.2"; - re125 is "F2-3.1"; - re126 is "F2-4.1"; - re127 is "F2-3.2"; - re128 is "F2-4.2"; - re129 is "F2-14.1"; - re130 is "F2-14.2"; - re131 is "F2-13.1"; - re132 is "F2-13.2"; - re133 is "F2-11.1"; - re134 is "F2-9.1"; - re135 is "F2-12.1"; - re136 is "F2-10.1"; - re137 is "F2-11.2"; - re138 is "F2-9.2"; - re139 is "F2-12.2"; - re140 is "F2-10.2"; - re141 is "F1-1"; - re154 is "F2-7.1"; - re155 is "F2-8.1"; - re156 is "F2-7.2"; - re157 is "F2-8.2"; - re158 is "F2-5.1.1"; - re159 is "F2-5.2.1"; - re160 is "F2-5.3.1"; - re161 is "F2-5.4.1"; - re162 is "F2-6.1.1"; - re163 is "F2-6.2.1"; - re164 is "F2-6.3.1"; - re165 is "F2-6.4.1"; - re166 is "F2-6.4.2"; - re167 is "F2-5.4.2"; - re168 is "F2-6.3.2"; - re169 is "F2-5.3.2"; - re170 is "F2-6.2.2"; - re171 is "F2-5.2.2"; - re172 is "F2-6.1.2"; - re173 is "F2-5.1.2"; - re174 is "D3-3"; - re175 is "D3-2"; - - // CV terms: - c1 identity "http://identifiers.org/go/GO:0005829" - c2 identity "http://identifiers.org/go/GO:0005783" - s2 identity "http://identifiers.org/uniprot/P00734" - s174 identity "http://identifiers.org/uniprot/P25116", - 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"http://identifiers.org/go/GO:0032027" - re137 identity "http://identifiers.org/ec-code/3.1.3.53", - "http://identifiers.org/kegg.reaction/R03151", - "http://identifiers.org/go/GO:0050115" - re138 identity "http://identifiers.org/ec-code/3.1.3.53", - "http://identifiers.org/kegg.reaction/R03151", - "http://identifiers.org/go/GO:0050115" - re139 identity "http://identifiers.org/ec-code/3.1.3.53", - "http://identifiers.org/kegg.reaction/R03151", - "http://identifiers.org/go/GO:0050115" - re140 identity "http://identifiers.org/ec-code/3.1.3.53", - "http://identifiers.org/kegg.reaction/R03151", - "http://identifiers.org/go/GO:0050115" - re141 identity "http://identifiers.org/go/GO:0017020", - "http://identifiers.org/go/GO:0006470" - re154 identity "http://identifiers.org/go/GO:0032027", - "http://identifiers.org/go/GO:0019901" - re155 identity "http://identifiers.org/go/GO:0032027", - "http://identifiers.org/go/GO:0019901" - re156 identity "http://identifiers.org/ec-code/2.7.11.18", - "http://identifiers.org/kegg.reaction/R03150", - "http://identifiers.org/go/GO:0004687" - re157 identity "http://identifiers.org/ec-code/2.7.11.18", - "http://identifiers.org/kegg.reaction/R03150", - "http://identifiers.org/go/GO:0004687" - re158 identity "http://identifiers.org/go/GO:0032027" - re158 parthood "http://identifiers.org/kegg.reaction/R03150" - re159 identity "http://identifiers.org/go/GO:0032027" - re159 parthood "http://identifiers.org/kegg.reaction/R03150" - re160 identity "http://identifiers.org/go/GO:0032027" - re160 parthood "http://identifiers.org/kegg.reaction/R03150" - re161 identity "http://identifiers.org/go/GO:0032027" - re161 parthood "http://identifiers.org/kegg.reaction/R03150" - re162 identity "http://identifiers.org/go/GO:0032027" - re162 parthood "http://identifiers.org/kegg.reaction/R03150" - re163 identity "http://identifiers.org/go/GO:0032027" - re163 identity "http://identifiers.org/kegg.reaction/R03150" - re164 identity "http://identifiers.org/go/GO:0032027" - re164 parthood "http://identifiers.org/kegg.reaction/R03150" - re165 identity "http://identifiers.org/go/GO:0032027" - re165 identity "http://identifiers.org/kegg.reaction/R03150" - re166 identity "http://identifiers.org/ec-code/2.7.11.18", - "http://identifiers.org/kegg.reaction/R03150", - "http://identifiers.org/go/GO:0004687" - re167 identity "http://identifiers.org/ec-code/2.7.11.18", - "http://identifiers.org/kegg.reaction/R03150", - "http://identifiers.org/go/GO:0004687" - re168 identity "http://identifiers.org/ec-code/2.7.11.18", - "http://identifiers.org/kegg.reaction/R03150", - "http://identifiers.org/go/GO:0004687" - re169 identity "http://identifiers.org/ec-code/2.7.11.18", - "http://identifiers.org/kegg.reaction/R03150", - "http://identifiers.org/go/GO:0004687" - re170 identity "http://identifiers.org/ec-code/2.7.11.18", - "http://identifiers.org/kegg.reaction/R03150", - "http://identifiers.org/go/GO:0004687" - re171 identity "http://identifiers.org/ec-code/2.7.11.18", - "http://identifiers.org/kegg.reaction/R03150", - "http://identifiers.org/go/GO:0004687" - re172 identity "http://identifiers.org/ec-code/2.7.11.18", - "http://identifiers.org/kegg.reaction/R03150", - "http://identifiers.org/go/GO:0004687" - re173 identity "http://identifiers.org/ec-code/2.7.11.18", - "http://identifiers.org/kegg.reaction/R03150", - "http://identifiers.org/go/GO:0004687" - re174 identity "http://identifiers.org/go/GO:0006816" - re175 identity "http://identifiers.org/go/GO:0006816" -end - -Maeda2006_MyosinPhosphorylation is "Maeda2006_MyosinPhosphorylation" - -Maeda2006_MyosinPhosphorylation model_entity_is "http://identifiers.org/biomodels.db/MODEL7944007619" -Maeda2006_MyosinPhosphorylation model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000088" -Maeda2006_MyosinPhosphorylation description "http://identifiers.org/pubmed/16923126" -Maeda2006_MyosinPhosphorylation taxon "http://identifiers.org/taxonomy/9606" -Maeda2006_MyosinPhosphorylation parthood "http://identifiers.org/kegg.pathway/hsa04810" -Maeda2006_MyosinPhosphorylation identity "http://identifiers.org/go/GO:0035023", - "http://identifiers.org/go/GO:0030036" diff --git a/BioModelsRAG/data/BIOMD0000000089.txt b/BioModelsRAG/data/BIOMD0000000089.txt deleted file mode 100644 index 22b41ccd91a7f5eeabfd9a4e6cd25cc43178df6d..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000089.txt +++ /dev/null @@ -1,424 +0,0 @@ -// Created by libAntimony v2.13.0 -function function_1(V, substrate, Km) - V*substrate/(Km + substrate); -end - -function_1.sboTerm = 29 - -function_1 is "degradation (Michaelis_Menten_Equation)" - - -model *Locke2006_CircClock_LL() - - // Compartments and Species: - compartment compartment_; - species cLm in compartment_, cLc in compartment_, cLn in compartment_, cTm in compartment_; - species cTc in compartment_, cTn in compartment_, cXm in compartment_, cXc in compartment_; - species cXn in compartment_, cYm in compartment_, cYc in compartment_, cYn in compartment_; - species cPn in compartment_, cAm in compartment_, cAc in compartment_, cAn in compartment_; - - // Reactions: - reaction_1: => cLm; (compartment_*g0^alpha/(g0^alpha + cAn^alpha))*(light*(q1*cPn + n0) + n1*cXn^a/(g1^a + cXn^a)); - reaction_0: cLm => ; compartment_*function_1(m1, cLm, k1); - reaction_2: => cLc; compartment_*p1*cLm; - reaction_3: cLc -> cLn; compartment_*(r1*cLc - r2*cLn); - reaction_4: cLc => ; compartment_*function_1(m2, cLc, k2); - reaction_5: cLn => ; compartment_*function_1(m3, cLn, k3); - reaction_6: => cTm; (compartment_*n2*cYn^b/(g2^b + cYn^b))*(g3^c/(g3^c + cLn^c)); - reaction_7: cTm => ; compartment_*function_1(m4, cTm, k4); - reaction_9: cYc -> cYn; compartment_*(r7*cYc - r8*cYn); - reaction_10: cYn => ; compartment_*function_1(m14, cYn, k12); - reaction_11: => cYc; compartment_*p4*cYm; - reaction_12: cYc => ; compartment_*function_1(m13, cYc, k11); - reaction_13: cXc -> cXn; compartment_*(r5*cXc - r6*cXn); - reaction_14: cXc => ; compartment_*function_1(m10, cXc, k8); - reaction_15: => cXc; compartment_*p3*cXm; - reaction_16: cXn => ; compartment_*function_1(m11, cXn, k9); - reaction_17: => cAc; compartment_*p6*cAm; - reaction_18: cAc -> cAn; compartment_*(r9*cAc - r10*cAn); - reaction_19: cAc => ; compartment_*function_1(m17, cAc, k15); - reaction_20: cAn => ; compartment_*function_1(m18, cAn, k16); - reaction_21: => cPn; (1 - light)*p5*compartment_; - reaction_22: cPn => ; q3*light*cPn*compartment_; - reaction_23: cPn => ; compartment_*m15*cPn/(k13 + cPn); - reaction_25: => cAm; light*q4*cPn*compartment_; - reaction_26: => cAm; compartment_*n6*cLn^g/(g7^g + cLn^g); - reaction_27: cAm => ; compartment_*m16*cAm/(k14 + cAm); - reaction_28: => cXm; compartment_*n3*cTn^d/(g4^d + cTn^d); - reaction_29: cXm => ; compartment_*m9*cXm/(k7 + cXm); - reaction_30: => cTc; p2*compartment_*cTm; - reaction_31: cTc -> cTn; compartment_*(-r4*cTn + r3*cTc); - reaction_32: cTc => ; compartment_*(1 - light)*m5*cTc/(k5 + cTc); - reaction_33: cTc => ; m6*compartment_*cTc/(k5 + cTc); - reaction_34: cTn => ; compartment_*(1 - light)*m7*cTn/(k6 + cTn); - reaction_38: cTn => ; m8*compartment_*cTn/(k6 + cTn); - reaction_39: => cYm; compartment_*(light*q2*cPn + (light*n4 + n5)*g5^e/(g5^e + cTn^e))*(g6^f/(g6^f + cLn^f)); - reaction_40: cYm => ; compartment_*m12*cYm/(k10 + cYm); - - // Species initializations: - cLm = 0.4625; - cLc = 0.0132; - cLn = 0.0699; - cTm = 0.4303; - cTc = 10.2965; - cTn = 0.5402; - cXm = 0.0957; - cXc = 1.5413; - cXn = 0.4585; - cYm = 0.0303; - cYc = 0.0041; - cYn = 0.0122; - cPn = 0.8476; - cAm = 14.6921; - cAc = 0.7027; - cAn = 0.8648; - - // Compartment initializations: - compartment_ = 1; - - // Variable initializations: - q1 = 4.1954; - n0 = 0.05; - g0 = 1; - alpha = 4; - n1 = 7.8142; - a = 1.2479; - g1 = 3.1383; - m1 = 1.999; - k1 = 2.392; - p1 = 0.8295; - r1 = 16.8363; - r2 = 0.1687; - m2 = 20.44; - k2 = 1.5644; - m3 = 3.6888; - k3 = 1.2765; - n2 = 3.0087; - b = 1.0258; - g2 = 0.0368; - g3 = 0.2658; - c = 1.0258; - m4 = 3.8231; - k4 = 2.5734; - p2 = 4.324; - r3 = 0.3166; - r4 = 2.1509; - m5 = 0.0013; - m6 = 3.1741; - k5 = 2.7454; - m7 = 0.0492; - m8 = 4.0424; - k6 = 0.4033; - n3 = 0.2431; - d = 1.4422; - g4 = 0.5388; - m9 = 10.1132; - k7 = 6.5585; - p3 = 2.147; - r5 = 1.0352; - r6 = 3.3017; - m10 = 0.2179; - k8 = 0.6632; - m11 = 3.3442; - k9 = 17.1111; - q2 = 2.4017; - n4 = 0.0857; - n5 = 0.1649; - g5 = 1.178; - g6 = 0.0645; - e = 3.6064; - f = 1.0237; - m12 = 4.297; - k10 = 1.7303; - p4 = 0.2485; - r7 = 2.2123; - r8 = 0.2002; - m13 = 0.1347; - k11 = 1.8258; - m14 = 0.6114; - k12 = 1.8066; - p5 = 0.5; - k13 = 1.2; - m15 = 1.2; - q3 = 1; - q4 = 2.4514; - g = 1.0258; - n6 = 8.0706; - g7 = 0.0004; - m16 = 12.2398; - k14 = 10.3617; - p6 = 0.2907; - r9 = 0.2528; - r10 = 0.2212; - m17 = 4.4505; - k15 = 0.0703; - m18 = 0.0156; - k16 = 0.6104; - light = 1; - - // Other declarations: - const compartment_, q1, n0, g0, alpha, n1, a, g1, m1, k1, p1, r1, r2, m2; - const k2, m3, k3, n2, b, g2, g3, c, m4, k4, p2, r3, r4, m5, m6, k5, m7; - const m8, k6, n3, d, g4, m9, k7, p3, r5, r6, m10, k8, m11, k9, q2, n4, n5; - const g5, g6, e, f, m12, k10, p4, r7, r8, m13, k11, m14, k12, p5, k13, m15; - const q3, q4, g, n6, g7, m16, k14, p6, r9, r10, m17, k15, m18, k16, light; - - // Unit definitions: - unit time_unit = 3600 second; - unit substance = 1e-9 mole; - - // Display Names: - substance is "nM"; - compartment_ is "cell"; - cLm is "LHY mRNA"; - cLc is "LHY protein in cytoplasm"; - cLn is "LHY protein in nucleus"; - cTm is "TOC1 mRNA"; - cTc is "TOC1 protein in cytoplasm"; - cTn is "TOC1 protein in nucleus"; - cXm is "X mRNA"; - cXc is "X protein in cytoplasm"; - cXn is "X protein in nucleus"; - cYm is "Y mRNA"; - cYc is "Y protein in the cytoplasm"; - cYn is "Y protein in nucleus"; - cPn is "light sensitive protein P"; - cAm is "PPR7/9 mRNA"; - cAc is "PPR7/9 protein in cytoplasm"; - cAn is "PPR7/9 protein in nucleus"; - reaction_1 is "cLm transcription"; - reaction_0 is "cLm degradation"; - reaction_2 is "cLc translation"; - reaction_3 is "LHY protein translocation"; - reaction_4 is "cLc degradation"; - reaction_5 is "cLn degradation"; - reaction_6 is "cTm transcription"; - reaction_7 is "cTm degradation"; - reaction_9 is "Y protein translocation"; - reaction_10 is "cYn degradation"; - reaction_11 is "cYc translation"; - reaction_12 is "cYc degradation"; - reaction_13 is "X protein translocation"; - reaction_14 is "cXc degradation"; - reaction_15 is "cXc translation"; - reaction_16 is "cXn degradation"; - reaction_17 is "cAc translation"; - reaction_18 is "PPR7/9 protein translocation"; - reaction_19 is "cAc degradation"; - reaction_20 is "cAn degradation"; - reaction_21 is "light dependent production of protein P"; - reaction_22 is "light activation protein P degradation"; - reaction_23 is "cPn degradation"; - reaction_25 is "light activation of cAm transcription"; - reaction_26 is "light independent cAm transcription"; - reaction_27 is "cAm degradation"; - reaction_28 is "cXm transcription"; - reaction_29 is "cXm degradation"; - reaction_30 is "cTc translation"; - reaction_31 is "TOC1 protein translocation"; - reaction_32 is "light activation degradation of cTc"; - reaction_33 is "light independent degradation of cTc"; - reaction_34 is "light activation degradation of cTn"; - reaction_38 is "light independent degradation cTn"; - reaction_39 is "cYm transcription"; - reaction_40 is "cYm degradation"; - - // SBO terms: - compartment_.sboTerm = 290 - cLm.sboTerm = 278 - cLc.sboTerm = 245 - cLn.sboTerm = 245 - cTm.sboTerm = 278 - cTc.sboTerm = 245 - cTn.sboTerm = 245 - cXm.sboTerm = 278 - cXc.sboTerm = 245 - cXn.sboTerm = 245 - cYm.sboTerm = 278 - cYc.sboTerm = 245 - cYn.sboTerm = 245 - cPn.sboTerm = 245 - cAm.sboTerm = 278 - cAc.sboTerm = 245 - cAn.sboTerm = 245 - q1.sboTerm = 337 - n0.sboTerm = 186 - g0.sboTerm = 186 - alpha.sboTerm = 261 - n1.sboTerm = 186 - a.sboTerm = 190 - g1.sboTerm = 363 - m1.sboTerm = 324 - k1.sboTerm = 27 - p1.sboTerm = 153 - r1.sboTerm = 153 - r2.sboTerm = 156 - m2.sboTerm = 324 - k2.sboTerm = 27 - m3.sboTerm = 324 - k3.sboTerm = 27 - n2.sboTerm = 186 - b.sboTerm = 190 - g2.sboTerm = 363 - g3.sboTerm = 261 - c.sboTerm = 190 - m4.sboTerm = 324 - k4.sboTerm = 27 - p2.sboTerm = 153 - r3.sboTerm = 153 - r4.sboTerm = 156 - m5.sboTerm = 324 - m6.sboTerm = 324 - k5.sboTerm = 27 - m7.sboTerm = 324 - m8.sboTerm = 324 - k6.sboTerm = 27 - n3.sboTerm = 186 - d.sboTerm = 190 - g4.sboTerm = 363 - m9.sboTerm = 324 - k7.sboTerm = 27 - p3.sboTerm = 153 - r5.sboTerm = 153 - r6.sboTerm = 156 - m10.sboTerm = 324 - k8.sboTerm = 27 - m11.sboTerm = 324 - k9.sboTerm = 27 - q2.sboTerm = 337 - n4.sboTerm = 186 - n5.sboTerm = 186 - g5.sboTerm = 261 - g6.sboTerm = 261 - e.sboTerm = 190 - f.sboTerm = 190 - m12.sboTerm = 324 - k10.sboTerm = 27 - p4.sboTerm = 153 - r7.sboTerm = 153 - r8.sboTerm = 156 - m13.sboTerm = 324 - k11.sboTerm = 27 - m14.sboTerm = 324 - k12.sboTerm = 27 - p5.sboTerm = 153 - k13.sboTerm = 27 - m15.sboTerm = 324 - q3.sboTerm = 337 - q4.sboTerm = 337 - g.sboTerm = 190 - n6.sboTerm = 186 - g7.sboTerm = 363 - m16.sboTerm = 324 - k14.sboTerm = 27 - p6.sboTerm = 153 - r9.sboTerm = 153 - r10.sboTerm = 156 - m17.sboTerm = 324 - k15.sboTerm = 27 - m18.sboTerm = 324 - k16.sboTerm = 27 - light.sboTerm = 492 - reaction_1.sboTerm = 183 - reaction_0.sboTerm = 179 - reaction_2.sboTerm = 184 - reaction_3.sboTerm = 185 - reaction_4.sboTerm = 179 - reaction_5.sboTerm = 179 - reaction_6.sboTerm = 183 - reaction_7.sboTerm = 179 - reaction_9.sboTerm = 185 - reaction_10.sboTerm = 179 - reaction_11.sboTerm = 184 - reaction_12.sboTerm = 179 - reaction_13.sboTerm = 185 - reaction_14.sboTerm = 179 - reaction_15.sboTerm = 184 - reaction_16.sboTerm = 179 - reaction_17.sboTerm = 184 - reaction_18.sboTerm = 185 - reaction_19.sboTerm = 179 - reaction_20.sboTerm = 179 - reaction_21.sboTerm = 393 - reaction_22.sboTerm = 179 - reaction_23.sboTerm = 179 - reaction_25.sboTerm = 183 - reaction_26.sboTerm = 183 - reaction_27.sboTerm = 179 - reaction_28.sboTerm = 183 - reaction_29.sboTerm = 179 - reaction_30.sboTerm = 184 - reaction_31.sboTerm = 185 - reaction_32.sboTerm = 179 - reaction_33.sboTerm = 179 - reaction_34.sboTerm = 179 - reaction_38.sboTerm = 179 - reaction_39.sboTerm = 183 - reaction_40.sboTerm = 179 - - // CV terms: - compartment_ hypernym "http://identifiers.org/go/GO:0005623" - cLm hypernym "http://identifiers.org/chebi/CHEBI:33699" - cLc version "http://identifiers.org/uniprot/O81713", - "http://identifiers.org/uniprot/P92973" - cLn version "http://identifiers.org/uniprot/P92973", - "http://identifiers.org/uniprot/O81713" - cTm hypernym "http://identifiers.org/chebi/CHEBI:33699" - cTc identity "http://identifiers.org/uniprot/Q9LKL2" - cTn identity "http://identifiers.org/uniprot/Q9LKL2" - cXm hypernym "http://identifiers.org/chebi/CHEBI:33699" - cYm hypernym "http://identifiers.org/chebi/CHEBI:33699" - cYc version "http://identifiers.org/uniprot/Q9SQI2" - cYn version "http://identifiers.org/uniprot/Q9SQI2" - cAm hypernym "http://identifiers.org/chebi/CHEBI:33699" - cAc part "http://identifiers.org/uniprot/Q93WK5", - "http://identifiers.org/uniprot/Q8L500" - cAn part "http://identifiers.org/uniprot/Q93WK5", - "http://identifiers.org/uniprot/Q8L500" - reaction_1 hypernym "http://identifiers.org/go/GO:0006351" - reaction_0 hypernym "http://identifiers.org/go/GO:0006402" - reaction_2 hypernym "http://identifiers.org/go/GO:0006412" - reaction_3 hypernym "http://identifiers.org/go/GO:0000060" - reaction_4 hypernym "http://identifiers.org/go/GO:0030163" - reaction_5 hypernym "http://identifiers.org/go/GO:0030163" - reaction_6 hypernym "http://identifiers.org/go/GO:0006351" - reaction_7 hypernym "http://identifiers.org/go/GO:0006402" - reaction_9 hypernym "http://identifiers.org/go/GO:0000060" - reaction_10 hypernym "http://identifiers.org/go/GO:0030163" - reaction_11 hypernym "http://identifiers.org/go/GO:0006412" - reaction_12 hypernym "http://identifiers.org/go/GO:0030163" - reaction_13 hypernym "http://identifiers.org/go/GO:0000060" - reaction_14 hypernym "http://identifiers.org/go/GO:0030163" - reaction_15 hypernym "http://identifiers.org/go/GO:0006412" - reaction_16 hypernym "http://identifiers.org/go/GO:0030163" - reaction_17 hypernym "http://identifiers.org/go/GO:0006412" - reaction_18 hypernym "http://identifiers.org/go/GO:0000060" - reaction_19 hypernym "http://identifiers.org/go/GO:0030163" - reaction_20 hypernym "http://identifiers.org/go/GO:0030163" - reaction_21 hypernym "http://identifiers.org/go/GO:0045727" - reaction_22 hypernym "http://identifiers.org/go/GO:0030163" - reaction_23 hypernym "http://identifiers.org/go/GO:0030163" - reaction_25 hypernym "http://identifiers.org/go/GO:0006351" - reaction_26 hypernym "http://identifiers.org/go/GO:0006351" - reaction_27 hypernym "http://identifiers.org/go/GO:0006402" - reaction_28 hypernym "http://identifiers.org/go/GO:0006351" - reaction_29 hypernym "http://identifiers.org/go/GO:0006402" - reaction_30 hypernym "http://identifiers.org/go/GO:0006412" - reaction_31 hypernym "http://identifiers.org/go/GO:0000060" - reaction_32 hypernym "http://identifiers.org/go/GO:0030163" - reaction_32 hypernym "http://identifiers.org/go/GO:0045732" - reaction_33 hypernym "http://identifiers.org/go/GO:0030163" - reaction_34 hypernym "http://identifiers.org/go/GO:0030163" - reaction_38 hypernym "http://identifiers.org/go/GO:0030163" - reaction_39 hypernym "http://identifiers.org/go/GO:0006351" - reaction_40 hypernym "http://identifiers.org/go/GO:0006402" -end - -Locke2006_CircClock_LL is "Locke2006_CircClock_LL" - -Locke2006_CircClock_LL model_entity_is "http://identifiers.org/biomodels.db/MODEL4025803561" -Locke2006_CircClock_LL model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000089" -Locke2006_CircClock_LL description "http://identifiers.org/pubmed/17102804" -Locke2006_CircClock_LL origin "http://identifiers.org/biomodels.db/BIOMD0000000055" -Locke2006_CircClock_LL taxon "http://identifiers.org/taxonomy/3702" -Locke2006_CircClock_LL hypernym "http://identifiers.org/go/GO:0042752" diff --git a/BioModelsRAG/data/BIOMD0000000090.txt b/BioModelsRAG/data/BIOMD0000000090.txt deleted file mode 100644 index c0ef63c2f114081cd89aacffb62642b5ea4b1148..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000090.txt +++ /dev/null @@ -1,217 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Wolf2001_Respiratory_Oscillations() - - // Compartments and Species: - compartment c0, c1, c2; - species $sul_ex in c0, $eth_ex in c0, $oxy_ex in c0, oxy in c2, $H2O in c2; - species A3c in c1, aps in c1, $PPi in c1, pap in c1, sul in c1, eth in c1; - species $A2c in c1, hyd in c1, cys in c1, N2 in c1, $N1 in c1, aco in c1; - species oah in c1, S1 in c2, $S2 in c2, $C1 in c2, $C2 in c2, $A2m in c2; - species A3m in c2, $Ho in c1, $Hm in c2; - - // Assignment Rules: - A2c := Ac - A3c; - N1 := N - N2; - S2 := S - S1; - A2m := Am - A3m; - - // Reactions: - v1: $sul_ex => sul; c0*k_v0/(1 + (cys/Kc)^n); - v13: $eth_ex => eth; c0*k_v13; - v2: sul + A3c => aps + $PPi; c1*k2*sul*A3c; - v10: $oxy_ex => oxy; c0*k_v10; - v14: oxy => $oxy_ex; c2*k14*oxy; - v3: aps + A3c => pap + $A2c; c1*k3*aps*A3c; - v4: pap + 3 N2 => hyd + 3 $N1; c1*k4*pap*N2; - v5: hyd + oah => cys; c1*k5*hyd*oah; - v6: cys => ; c1*k6*cys; - v7: eth + 2 $N1 => aco + 2 N2; c1*k7*eth*N1; - v15: aco => oah; c1*k15*aco; - v17: hyd => ; c1*k17*hyd; - v18: oah => ; c1*k18*oah; - v8: $S2 + aco => S1; c2*k8*aco*S2; - v9: S1 + 4 $N1 => $S2 + 4 N2; c2*k9*S1*N1; - v11a: $C1 + $Hm + N2 => $C2 + $Ho + $N1; c2*k11*N2*oxy/((a*N2 + oxy)*(1 + (hyd/Kh)^m)); - v11a2: $C2 + oxy => $C1 + $H2O; c2*k11*N2*oxy/((a*N2 + oxy)*(1 + (hyd/Kh)^m)); - v16: $A2c + A3m => $A2m + A3c; c2*k16*A3m*A2c; - v11b: $Ho + $A2m => $Hm + A3m; (c2*3*k11*N2*oxy/((a*N2 + oxy)*(1 + (hyd/Kh)^m)))*A2m/(Ka + A2m); - vLEAK: $Ho => $Hm; 0; - v12: A3c => $A2c; c1*k12*A3c; - - // Species initializations: - sul_ex = 0; - eth_ex = 0; - oxy_ex = 0; - oxy = 7; - oxy has substance_per_volume; - H2O = 0; - A3c = 1.5; - A3c has substance_per_volume; - aps = 0.5; - aps has substance_per_volume; - PPi = 0; - pap = 0.4; - pap has substance_per_volume; - sul = 0.4; - sul has substance_per_volume; - eth = 4; - eth has substance_per_volume; - A2c has substance_per_volume; - hyd = 0.5; - hyd has substance_per_volume; - cys = 0.3; - cys has substance_per_volume; - N2 = 2; - N2 has substance_per_volume; - N1 has substance_per_volume; - aco = 0.3; - aco has substance_per_volume; - oah = 1.5; - oah has substance_per_volume; - S1 = 1.5; - S1 has substance_per_volume; - S2 has substance_per_volume; - C1 = 0; - C2 = 0; - A2m has substance_per_volume; - A3m = 1.5; - A3m has substance_per_volume; - Ho = 0; - Hm = 0; - - // Compartment initializations: - c0 = 1; - c1 = 1; - c2 = 1; - - // Variable initializations: - Ac = 2; - N = 2; - S = 2; - Am = 2; - k_v0 = 1.6; - k2 = 0.2; - k3 = 0.2; - k4 = 0.2; - k5 = 0.1; - k6 = 0.12; - k7 = 10; - k8 = 10; - k9 = 10; - k_v10 = 80; - k11 = 10; - k12 = 5; - k_v13 = 4; - k14 = 10; - k15 = 5; - k16 = 10; - k17 = 0.02; - k18 = 1; - n = 4; - m = 4; - Ka = 1; - Kc = 0.1; - a = 0.1; - Kh = 0.5; - - // Other declarations: - const c0, c1, c2, Ac, N, S, Am, k_v0, k2, k3, k4, k5, k6, k7, k8, k9, k_v10; - const k11, k12, k_v13, k14, k15, k16, k17, k18, n, m, Ka, Kc, a, Kh; - - // Unit definitions: - unit substance = mole; - unit substance_per_volume = mole / litre; - - // Display Names: - c0 is "external"; - c1 is "cytosol"; - c2 is "mitochondria"; - sul_ex is "SO4_ex"; - eth_ex is "EtOH_ex"; - oxy_ex is "O2_ex"; - oxy is "O2"; - A3c is "ATP"; - aps is "APS"; - pap is "PAPS"; - sul is "SO4"; - eth is "EtOH"; - A2c is "ADP"; - hyd is "H2S"; - cys is "CYS"; - N2 is "NADH"; - N1 is "NAD"; - aco is "AcCoA"; - oah is "OAH"; - A2m is "ADP_mit"; - A3m is "ATP_mit"; - v11a is "vET1"; - v11a2 is "vET2"; - v11b is "vSYNT"; - - // CV terms: - c0 hypernym "http://identifiers.org/obo.go/GO:0005576" - c1 hypernym "http://identifiers.org/obo.go/GO:0005829" - c2 hypernym "http://identifiers.org/obo.go/GO:0005739" - sul_ex identity "http://identifiers.org/obo.chebi/CHEBI:16189" - eth_ex identity "http://identifiers.org/obo.chebi/CHEBI:16236" - oxy_ex identity "http://identifiers.org/obo.chebi/CHEBI:15379" - oxy identity "http://identifiers.org/obo.chebi/CHEBI:15379" - H2O identity "http://identifiers.org/obo.chebi/CHEBI:15377" - A3c identity "http://identifiers.org/obo.chebi/CHEBI:15422" - aps identity "http://identifiers.org/obo.chebi/CHEBI:17709" - PPi identity "http://identifiers.org/obo.chebi/CHEBI:18361" - pap identity "http://identifiers.org/obo.chebi/CHEBI:17980" - sul identity "http://identifiers.org/obo.chebi/CHEBI:16189" - eth identity "http://identifiers.org/obo.chebi/CHEBI:16236" - A2c identity "http://identifiers.org/obo.chebi/CHEBI:16761" - hyd identity "http://identifiers.org/obo.chebi/CHEBI:16136" - cys identity "http://identifiers.org/obo.chebi/CHEBI:17561" - N2 identity "http://identifiers.org/obo.chebi/CHEBI:16908" - N1 identity "http://identifiers.org/obo.chebi/CHEBI:15846" - aco identity "http://identifiers.org/obo.chebi/CHEBI:15351" - oah identity "http://identifiers.org/obo.chebi/CHEBI:16288" - S1 parthood "http://identifiers.org/obo.go/GO:0030062" - S2 parthood "http://identifiers.org/obo.go/GO:0030062" - C1 hypernym "http://identifiers.org/obo.go/GO:0005746" - C2 hypernym "http://identifiers.org/obo.go/GO:0005746" - A2m identity "http://identifiers.org/obo.chebi/CHEBI:16761" - A3m identity "http://identifiers.org/obo.chebi/CHEBI:15422" - Ho identity "http://identifiers.org/obo.chebi/CHEBI:24636" - Hm identity "http://identifiers.org/obo.chebi/CHEBI:24636" - v1 hypernym "http://identifiers.org/obo.go/GO:0015381" - v13 hypernym "http://identifiers.org/obo.go/GO:0015850" - v2 identity "http://identifiers.org/ec-code/2.7.7.4" - v3 identity "http://identifiers.org/ec-code/2.7.1.25" - v3 hypernym "http://identifiers.org/obo.go/GO:0004020" - v4 version "http://identifiers.org/ec-code/1.8.4.8", - "http://identifiers.org/ec-code/1.8.1.2" - v5 version "http://identifiers.org/ec-code/4.4.1.1", - "http://identifiers.org/ec-code/4.2.1.22", - "http://identifiers.org/ec-code/2.5.1.49" - v7 version "http://identifiers.org/ec-code/6.2.1.1", - "http://identifiers.org/ec-code/1.2.1.3", - "http://identifiers.org/ec-code/1.1.1.1" - v15 identity "http://identifiers.org/ec-code/2.3.1.31" - v8 parthood "http://identifiers.org/obo.go/GO:0006099" - v9 parthood "http://identifiers.org/obo.go/GO:0006099" - v11a identity "http://identifiers.org/obo.go/GO:0015990" - v11a parthood "http://identifiers.org/obo.go/GO:0042775" - v11a version "http://identifiers.org/obo.go/GO:0002082" - v11a2 parthood "http://identifiers.org/obo.go/GO:0042775" - v11a2 version "http://identifiers.org/obo.go/GO:0002082" - v11a2 identity "http://identifiers.org/obo.go/GO:0006123" - v16 identity "http://identifiers.org/obo.go/GO:0005471" - v11b parthood "http://identifiers.org/obo.go/GO:0042775" - v11b hypernym "http://identifiers.org/obo.go/GO:0006119" - v11b version "http://identifiers.org/obo.go/GO:0002082" - vLEAK hypernym "http://identifiers.org/obo.go/GO:0006810" - v12 hypernym "http://identifiers.org/obo.go/GO:0006200" -end - -Wolf2001_Respiratory_Oscillations is "Wolf2001_Respiratory_Oscillations" - -Wolf2001_Respiratory_Oscillations model_entity_is "http://identifiers.org/biomodels.db/MODEL9728951048" -Wolf2001_Respiratory_Oscillations model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000090" -Wolf2001_Respiratory_Oscillations description "http://identifiers.org/pubmed/11423122" -Wolf2001_Respiratory_Oscillations taxon "http://identifiers.org/taxonomy/4932" -Wolf2001_Respiratory_Oscillations hypernym "http://identifiers.org/obo.go/GO:0019379" diff --git a/BioModelsRAG/data/BIOMD0000000091.txt b/BioModelsRAG/data/BIOMD0000000091.txt deleted file mode 100644 index d3ed48f239d81265088ee70ce40e12133c1606de..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000091.txt +++ /dev/null @@ -1,144 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Proctor2005_Hsp90() - - // Compartments and Species: - compartment compartment_; - substanceOnly species Hsp90 in compartment_, HCom in compartment_, HSF1 in compartment_; - substanceOnly species MisP in compartment_, MCom in compartment_, TriH in compartment_; - substanceOnly species DiH in compartment_, NatP in compartment_, AggP in compartment_; - substanceOnly species HSE in compartment_, HSETriH in compartment_, X in compartment_; - substanceOnly species ROS in compartment_, ATP in compartment_, ADP in compartment_; - substanceOnly species $source in compartment_; - - // Reactions: - proteinSynthesis: 0 $source => NatP; k1; - misfolding: NatP + ROS => MisP + ROS; k2*NatP*ROS; - Hsp90MisPBinding: MisP + Hsp90 => MCom; k3*MisP*Hsp90; - unsuccessulRefolding: MCom => MisP + Hsp90; k4*MCom; - refolding: MCom + ATP => Hsp90 + NatP + ADP; k5*MCom*ATP; - proteinDegradation: MisP + ATP => ADP; k6*MisP*ATP; - proteinAggregation1: 2 MisP => AggP; (MisP - 1)*k7*MisP/2; - proteinAggregation2: MisP + AggP => 2 AggP; k7*MisP*AggP; - Hsp90HSF1Binding: Hsp90 + HSF1 => HCom; k8*Hsp90*HSF1; - Hsp90HSF1Release: HCom => Hsp90 + HSF1; k9*HCom; - dimerisation: 2 HSF1 => DiH; (HSF1 - 1)*k10*HSF1/2; - trimerisation: HSF1 + DiH => TriH; k11*HSF1*DiH; - deTrimerisation: TriH => HSF1 + DiH; k12*TriH; - deDimerisation: DiH => 2 HSF1; k13*DiH; - HSETriHBinding: TriH + HSE => HSETriH; k14*HSE*TriH; - HSETriHRelease: HSETriH => HSE + TriH; k15*HSETriH; - Hsp90Transcription: HSETriH => HSETriH + Hsp90; k16*HSETriH; - Hsp90Degradation: Hsp90 + ATP => ADP; k17*Hsp90*ATP; - countTime: 0 $source => X; 1; - ATPformation: ADP => ATP; k18*ADP; - ATPconsumption: ATP => ADP; k19*ATP; - radicalFormation: 0 $source => ROS; k20; - radicalScavenging: ROS => ; k21*ROS; - - // Species initializations: - Hsp90 = 300000/compartment_; - HCom = 5900/compartment_; - HSF1 = 100/compartment_; - MisP = 0; - MCom = 0; - TriH = 0; - DiH = 0; - NatP = 6000000/compartment_; - AggP = 0; - HSE = 1/compartment_; - HSETriH = 0; - X = 0; - ROS = 100/compartment_; - ATP = 10000/compartment_; - ADP = 1000/compartment_; - source = 0; - - // Compartment initializations: - compartment_ = 1; - - // Variable initializations: - k1 = 10; - k2 = 2e-05; - k3 = 50; - k4 = 1e-05; - k5 = 4e-06; - k6 = 6e-07; - k7 = 1e-07; - k8 = 500; - k9 = 1; - k10 = 0.01; - k11 = 100; - k12 = 0.5; - k13 = 0.5; - k14 = 0.05; - k15 = 0.08; - k16 = 1000; - k17 = 8.02e-09; - k18 = 12; - k19 = 0.02; - k20 = 0.1; - k21 = 0.001; - - // Other declarations: - const compartment_, k1, k2, k3, k4, k5, k6, k7, k8, k9, k10, k11, k12, k13; - const k14, k15, k16, k17, k18, k19, k20, k21; - - // Unit definitions: - unit substance = item; - - // Display Names: - unsuccessulRefolding is "unsuccessfulRefolding"; - - // CV terms: - compartment_ hypernym "http://identifiers.org/go/GO:0005623" - Hsp90 identity "http://identifiers.org/interpro/IPR001404" - HCom hypernym "http://identifiers.org/go/GO:0043234" - HSF1 hypernym "http://identifiers.org/interpro/IPR000232" - MCom hypernym "http://identifiers.org/go/GO:0043234" - TriH hypernym "http://identifiers.org/go/GO:0043234" - TriH part "http://identifiers.org/interpro/IPR000232" - DiH hypernym "http://identifiers.org/go/GO:0043234" - DiH part "http://identifiers.org/interpro/IPR000232" - ROS hypernym "http://identifiers.org/chebi/CHEBI:26523" - ATP identity "http://identifiers.org/chebi/CHEBI:15422", - "http://identifiers.org/kegg.compound/C00002" - ADP identity "http://identifiers.org/chebi/CHEBI:16761", - "http://identifiers.org/kegg.compound/C00008" - proteinSynthesis hypernym "http://identifiers.org/go/GO:0009059" - misfolding version "http://identifiers.org/go/GO:0022417" - Hsp90MisPBinding hypernym "http://identifiers.org/go/GO:0051879" - unsuccessulRefolding hypernym "http://identifiers.org/go/GO:0043624" - refolding hypernym "http://identifiers.org/go/GO:0042026", - "http://identifiers.org/go/GO:0016887" - proteinDegradation hypernym "http://identifiers.org/go/GO:0016887" - proteinAggregation1 hypernym "http://identifiers.org/go/GO:0043623" - proteinAggregation2 hypernym "http://identifiers.org/go/GO:0043623" - Hsp90HSF1Binding hypernym "http://identifiers.org/go/GO:0051879" - Hsp90HSF1Release hypernym "http://identifiers.org/go/GO:0043624" - dimerisation hypernym "http://identifiers.org/go/GO:0043623" - trimerisation hypernym "http://identifiers.org/go/GO:0043623" - deTrimerisation hypernym "http://identifiers.org/go/GO:0043624" - deDimerisation hypernym "http://identifiers.org/go/GO:0043624" - HSETriHBinding hypernym "http://identifiers.org/go/GO:0043623" - HSETriHRelease hypernym "http://identifiers.org/go/GO:0043624" - Hsp90Transcription hypernym "http://identifiers.org/go/GO:0006351" - Hsp90Degradation hypernym "http://identifiers.org/go/GO:0044257", - "http://identifiers.org/go/GO:0016887" - ATPformation hypernym "http://identifiers.org/go/GO:0006757" - ATPconsumption hypernym "http://identifiers.org/go/GO:0016887" - radicalFormation parthood "http://identifiers.org/go/GO:0006800" - radicalScavenging hypernym "http://identifiers.org/go/GO:0016209" -end - -Proctor2005_Hsp90 is "Proctor2005 - Actions of chaperones and their role in ageing" - -Proctor2005_Hsp90 model_entity_is "http://identifiers.org/biomodels.db/MODEL2223638385" -Proctor2005_Hsp90 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000091" -Proctor2005_Hsp90 description "http://identifiers.org/pubmed/15610770" -Proctor2005_Hsp90 hypernym "http://identifiers.org/go/GO:0051085", - "http://identifiers.org/go/GO:0007569", - "http://identifiers.org/go/GO:0009408" -Proctor2005_Hsp90 taxon "http://identifiers.org/taxonomy/131567" -Proctor2005_Hsp90 version "http://identifiers.org/doid/DOID:10652", - "http://identifiers.org/doid/DOID:14330", - "http://identifiers.org/doid/DOID:83" diff --git a/BioModelsRAG/data/BIOMD0000000092.txt b/BioModelsRAG/data/BIOMD0000000092.txt deleted file mode 100644 index 2cae152a944a654bad7df4fc8e8c90df0ad3e60f..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000092.txt +++ /dev/null @@ -1,65 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Fuentes2005_ZymogenActivation() - - // Compartments and Species: - compartment compartment_; - species z in compartment_, e in compartment_, w in compartment_, ez in compartment_; - - // Reactions: - v1: z -> w + e; compartment_*v1_k1*z; - v2: z + e -> ez; compartment_*(v2_k21*e*z - v2_k22*ez); - v3: ez -> w + 2 e; compartment_*v3_k3*ez; - - // Species initializations: - z = 2.4e-05; - e = 0; - w = 0; - ez = 0; - - // Compartment initializations: - compartment_ = 1; - - // Variable initializations: - v1_k1 = 0.004; - v1_k1 has sec_inv; - v2_k21 = 1000; - v2_k21 has M_inv_sec_inv; - v2_k22 = 0.00021; - v2_k22 has sec_inv; - v3_k3 = 0.00054; - v3_k3 has sec_inv; - - // Other declarations: - const compartment_; - - // Unit definitions: - unit M_inv_sec_inv = litre / (mole * second); - unit sec_inv = 1 / second; - - // Display Names: - compartment_ is "compartment"; - z is "Zymogen"; - e is "Enzyme"; - w is "Peptide"; - ez is "Enzyme-Substrate complex"; - v1 is "Intramolecular autoactivation"; - v2 is "Intermolecular autoactivation-Complex formation"; - v3 is "Intermolecular autoactivation-Enzyme release"; - - // CV terms: - compartment_ identity "http://identifiers.org/go/GO:0005623" - z parthood "http://identifiers.org/go/GO:0042588" - ez hypernym "http://identifiers.org/go/GO:0043234" - v1 hypernym "http://identifiers.org/go/GO:0043085" - v2 hypernym "http://identifiers.org/go/GO:0019899" - v3 hypernym "http://identifiers.org/go/GO:0043085" -end - -Fuentes2005_ZymogenActivation is "Fuentes2005_ZymogenActivation" - -Fuentes2005_ZymogenActivation model_entity_is "http://identifiers.org/biomodels.db/MODEL6623597435" -Fuentes2005_ZymogenActivation model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000092" -Fuentes2005_ZymogenActivation description "http://identifiers.org/pubmed/15634334" -Fuentes2005_ZymogenActivation origin "http://identifiers.org/pubmed/7558" -Fuentes2005_ZymogenActivation identity "http://identifiers.org/go/GO:0031638" -Fuentes2005_ZymogenActivation taxon "http://identifiers.org/taxonomy/131567" diff --git a/BioModelsRAG/data/BIOMD0000000093.txt b/BioModelsRAG/data/BIOMD0000000093.txt deleted file mode 100644 index 952286ae72ec0f141315d935572e10fecc90cbeb..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000093.txt +++ /dev/null @@ -1,458 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Yamada2003_JAK_STAT_Pathway() - - // Compartments and Species: - compartment cytoplasm, nucleus; - species R in cytoplasm, JAK in cytoplasm, RJ in cytoplasm, IFNRJ in cytoplasm; - species IFNRJ2 in cytoplasm, IFNRJ2_star in cytoplasm, STAT1c in cytoplasm; - species IFNRJ2_star_STAT1c in cytoplasm, STAT1c_star in cytoplasm, IFNRJ2_star_STAT1c_star in cytoplasm; - species STAT1c_star_STAT1c_star in cytoplasm, SHP2 in cytoplasm, IFNRJ2_star_SHP2 in cytoplasm; - species PPX in cytoplasm, STAT1c_star_PPX in cytoplasm, STAT1c_STAT1c_star in cytoplasm; - species STAT1n_star_STAT1n_star in nucleus, STAT1n_star in nucleus, PPN in nucleus; - species STAT1n_star_PPN in nucleus, STAT1n in nucleus, STAT1n_STAT1n_star in nucleus; - species mRNAn in nucleus, mRNAc in cytoplasm, SOCS1 in cytoplasm, IFNRJ2_star_SOCS1 in cytoplasm; - species IFNRJ2_star_SHP2_SOCS1_STAT1c in cytoplasm, STAT1c_star_STAT1c_star_PPX in cytoplasm; - species STAT1n_star_STAT1n_star_PPN in nucleus, IFNRJ2_star_SOCS1_STAT1c in cytoplasm; - species $IFN in cytoplasm, IFNRJ2_star_SHP2_STAT1c in cytoplasm, IFNRJ2_star_SHP2_SOCS1 in cytoplasm; - species IFNR in cytoplasm; - - // Reactions: - v1: JAK + R => RJ; cytoplasm*(v1_kf*R*JAK - v1_kb*RJ); - v2: RJ + $IFN => IFNRJ; cytoplasm*(v2_kf*IFN*RJ - v2_kb*IFNRJ); - v3: 2 IFNRJ => IFNRJ2; cytoplasm*(v3_kf*IFNRJ*IFNRJ - v3_kb*IFNRJ2); - v4: IFNRJ2 => IFNRJ2_star; cytoplasm*v4_kf*IFNRJ2; - v5: IFNRJ2_star + STAT1c => IFNRJ2_star_STAT1c; cytoplasm*(v5_kf*STAT1c*IFNRJ2_star - v5_kb*IFNRJ2_star_STAT1c); - v6: IFNRJ2_star_STAT1c => STAT1c_star + IFNRJ2_star; cytoplasm*v6_kf*IFNRJ2_star_STAT1c; - v7: STAT1c_star + IFNRJ2_star => IFNRJ2_star_STAT1c_star; cytoplasm*(v7_kf*IFNRJ2_star*STAT1c_star - v7_kb*IFNRJ2_star_STAT1c_star); - v8: 2 STAT1c_star => STAT1c_star_STAT1c_star; cytoplasm*(v8_kf*STAT1c_star*STAT1c_star - v8_kb*STAT1c_star_STAT1c_star); - v9: SHP2 + IFNRJ2_star => IFNRJ2_star_SHP2; cytoplasm*(v9_kf*IFNRJ2_star*SHP2 - v9_kb*IFNRJ2_star_SHP2); - v10: IFNRJ2_star_SHP2 => SHP2 + IFNRJ2; cytoplasm*v10_kf*IFNRJ2_star_SHP2; - v11: STAT1c_star + PPX => STAT1c_star_PPX; cytoplasm*(v11_kf*PPX*STAT1c_star - v11_kb*STAT1c_star_PPX); - v12: STAT1c_star_PPX => STAT1c + PPX; cytoplasm*v12_kf*STAT1c_star_PPX; - v13: STAT1c_star_STAT1c_star + PPX => STAT1c_star_STAT1c_star_PPX; cytoplasm*(v13_kf*PPX*STAT1c_star_STAT1c_star - v13_kb*STAT1c_star_STAT1c_star_PPX); - v14: STAT1c_star_STAT1c_star_PPX => STAT1c_STAT1c_star + PPX; cytoplasm*v14_kf*STAT1c_star_STAT1c_star_PPX; - v15: STAT1c_star + STAT1c => STAT1c_STAT1c_star; cytoplasm*(v15_kf*STAT1c*STAT1c_star - v15_kb*STAT1c_STAT1c_star); - v16: STAT1c_star_STAT1c_star => STAT1n_star_STAT1n_star; cytoplasm*v16_kf*STAT1c_star_STAT1c_star; - v17: 2 STAT1n_star => STAT1n_star_STAT1n_star; nucleus*(v17_kf*STAT1n_star*STAT1n_star - v17_kb*STAT1n_star_STAT1n_star); - v18: STAT1n_star + PPN => STAT1n_star_PPN; nucleus*(v18_kf*PPN*STAT1n_star - v18_kb*STAT1n_star_PPN); - v19: STAT1n_star_PPN => STAT1n + PPN; nucleus*v19_kf*STAT1n_star_PPN; - v20: STAT1n_star_STAT1n_star + PPN => STAT1n_star_STAT1n_star_PPN; nucleus*(v20_kf*PPN*STAT1n_star_STAT1n_star - v20_kb*STAT1n_star_STAT1n_star_PPN); - v21: STAT1n_star_STAT1n_star_PPN => STAT1n_STAT1n_star + PPN; nucleus*v21_kf*STAT1n_star_STAT1n_star_PPN; - v22: STAT1n_star + STAT1n => STAT1n_STAT1n_star; nucleus*(v22_kf*STAT1n*STAT1n_star - v22_kb*STAT1n_STAT1n_star); - v23: STAT1n => STAT1c; nucleus*v23_kf*STAT1n; - v24: => mRNAn; nucleus*v24_ka*STAT1n_star_STAT1n_star/(v24_kb + STAT1n_star_STAT1n_star); - v25: mRNAn => mRNAc; nucleus*v25_kf*mRNAn; - v26: => SOCS1; cytoplasm*v26_kf*mRNAc; - v27: mRNAc => ; cytoplasm*v27_kf*mRNAc; - v28: SOCS1 => ; cytoplasm*v28_kf*SOCS1; - v29: IFNRJ2_star + SOCS1 => IFNRJ2_star_SOCS1; cytoplasm*(v29_kf*SOCS1*IFNRJ2_star - v29_kb*IFNRJ2_star_SOCS1); - v30: IFNRJ2_star_SOCS1 + STAT1c => IFNRJ2_star_SOCS1_STAT1c; cytoplasm*(v30_kf*STAT1c*IFNRJ2_star_SOCS1 - v30_kb*IFNRJ2_star_SOCS1_STAT1c); - v31: IFNRJ2_star_SOCS1_STAT1c + SHP2 => IFNRJ2_star_SHP2_SOCS1_STAT1c; cytoplasm*(v31_kf*SHP2*IFNRJ2_star_SOCS1_STAT1c - v31_kb*IFNRJ2_star_SHP2_SOCS1_STAT1c); - v32: IFNRJ2_star_SHP2_SOCS1_STAT1c => IFNRJ2 + SOCS1 + STAT1c + SHP2; cytoplasm*v32_kf*IFNRJ2_star_SHP2_SOCS1_STAT1c; - v33: IFNRJ2_star_SHP2_SOCS1_STAT1c => IFNRJ2_star_SHP2_STAT1c; cytoplasm*v33_kf*IFNRJ2_star_SHP2_SOCS1_STAT1c; - v34: IFNRJ2_star_SOCS1 + SHP2 => IFNRJ2_star_SHP2_SOCS1; cytoplasm*(v34_kf*SHP2*IFNRJ2_star_SOCS1 - v34_kb*IFNRJ2_star_SHP2_SOCS1); - v35: IFNRJ2_star_SHP2_SOCS1 + STAT1c => IFNRJ2_star_SHP2_SOCS1_STAT1c; cytoplasm*(v35_kf*STAT1c*IFNRJ2_star_SHP2_SOCS1 - v35_kb*IFNRJ2_star_SHP2_SOCS1_STAT1c); - v36: IFNRJ2_star_STAT1c + SHP2 => IFNRJ2_star_SHP2_STAT1c; cytoplasm*(v36_kf*SHP2*IFNRJ2_star_STAT1c - v36_kb*IFNRJ2_star_SHP2_STAT1c); - v37: IFNRJ2_star_SHP2_STAT1c => STAT1c + SHP2 + IFNRJ2; cytoplasm*v37_kf*IFNRJ2_star_SHP2_STAT1c; - v38: IFNRJ2_star_SOCS1_STAT1c => IFNRJ2_star_STAT1c; cytoplasm*v38_kf*IFNRJ2_star_SOCS1_STAT1c; - v39: IFNRJ2_star_SHP2_SOCS1 => IFNRJ2_star_SHP2; cytoplasm*v39_kf*IFNRJ2_star_SHP2_SOCS1; - v40: IFNRJ2_star_SHP2_SOCS1 => SHP2 + IFNRJ2 + SOCS1; cytoplasm*v40_kf*IFNRJ2_star_SHP2_SOCS1; - v41: IFNRJ2_star_SOCS1 => IFNRJ2_star; cytoplasm*v41_kf*IFNRJ2_star_SOCS1; - v42: IFNRJ2_star_STAT1c + SOCS1 => IFNRJ2_star_SOCS1_STAT1c; cytoplasm*(v42_kf*SOCS1*IFNRJ2_star_STAT1c - v42_kb*IFNRJ2_star_SOCS1_STAT1c); - v43: IFNRJ2_star_SHP2 + SOCS1 => IFNRJ2_star_SHP2_SOCS1; cytoplasm*(v43_kf*SOCS1*IFNRJ2_star_SHP2 - v43_kb*IFNRJ2_star_SHP2_SOCS1); - v44: IFNRJ2_star_SHP2_STAT1c + SOCS1 => IFNRJ2_star_SHP2_SOCS1_STAT1c; cytoplasm*(v44_kf*SOCS1*IFNRJ2_star_SHP2_STAT1c - v44_kb*IFNRJ2_star_SHP2_SOCS1_STAT1c); - v45: R + $IFN => IFNR; cytoplasm*(v45_kf*IFN*R - v45_kb*IFNR); - v46: JAK + IFNR => IFNRJ; cytoplasm*(v46_kf*IFNR*JAK - v46_kb*IFNRJ); - - // Species initializations: - R = 10; - JAK = 10; - RJ = 0; - IFNRJ = 0; - IFNRJ2 = 0; - IFNRJ2_star = 0; - STAT1c = 1000; - IFNRJ2_star_STAT1c = 0; - STAT1c_star = 0; - IFNRJ2_star_STAT1c_star = 0; - STAT1c_star_STAT1c_star = 0; - SHP2 = 100; - IFNRJ2_star_SHP2 = 0; - PPX = 50; - STAT1c_star_PPX = 0; - STAT1c_STAT1c_star = 0; - STAT1n_star_STAT1n_star = 0; - STAT1n_star = 0; - PPN = 60; - STAT1n_star_PPN = 0; - STAT1n = 0; - STAT1n_STAT1n_star = 0; - mRNAn = 0; - mRNAc = 0; - SOCS1 = 0; - IFNRJ2_star_SOCS1 = 0; - IFNRJ2_star_SHP2_SOCS1_STAT1c = 0; - STAT1c_star_STAT1c_star_PPX = 0; - STAT1n_star_STAT1n_star_PPN = 0; - IFNRJ2_star_SOCS1_STAT1c = 0; - IFN = 10; - IFNRJ2_star_SHP2_STAT1c = 0; - IFNRJ2_star_SHP2_SOCS1 = 0; - IFNR = 0; - - // Compartment initializations: - cytoplasm = 1; - nucleus = 1; - - // Variable initializations: - v1_kf = 0.1; - v1_kf has nM_inv_sec_inv; - v1_kb = 0.05; - v1_kb has sec_inv; - v2_kf = 0.02; - v2_kf has nM_inv_sec_inv; - v2_kb = 0.02; - v2_kb has sec_inv; - v3_kf = 0.04; - v3_kf has nM_inv_sec_inv; - v3_kb = 0.2; - v3_kb has sec_inv; - v4_kf = 0.005; - v4_kf has sec_inv; - v5_kf = 0.008; - v5_kf has nM_inv_sec_inv; - v5_kb = 0.8; - v5_kb has sec_inv; - v6_kf = 0.4; - v6_kf has sec_inv; - v7_kf = 0.005; - v7_kf has nM_inv_sec_inv; - v7_kb = 0.5; - v7_kb has sec_inv; - v8_kf = 0.02; - v8_kf has nM_inv_sec_inv; - v8_kb = 0.1; - v8_kb has sec_inv; - v9_kf = 0.001; - v9_kf has nM_inv_sec_inv; - v9_kb = 0.2; - v9_kb has sec_inv; - v10_kf = 0.003; - v10_kf has sec_inv; - v11_kf = 0.001; - v11_kf has nM_inv_sec_inv; - v11_kb = 0.2; - v11_kb has sec_inv; - v12_kf = 0.003; - v12_kf has sec_inv; - v13_kf = 0.001; - v13_kf has nM_inv_sec_inv; - v13_kb = 0.2; - v13_kb has sec_inv; - v14_kf = 0.003; - v14_kf has sec_inv; - v15_kf = 2e-07; - v15_kf has nM_inv_sec_inv; - v15_kb = 0.2; - v15_kb has sec_inv; - v16_kf = 0.005; - v16_kf has sec_inv; - v17_kf = 0.02; - v17_kf has nM_inv_sec_inv; - v17_kb = 0.1; - v17_kb has sec_inv; - v18_kf = 0.001; - v18_kf has nM_inv_sec_inv; - v18_kb = 0.2; - v18_kb has sec_inv; - v19_kf = 0.005; - v19_kf has sec_inv; - v20_kf = 0.001; - v20_kf has nM_inv_sec_inv; - v20_kb = 0.2; - v20_kb has sec_inv; - v21_kf = 0.005; - v21_kf has sec_inv; - v22_kf = 2e-07; - v22_kf has nM_inv_sec_inv; - v22_kb = 0.2; - v22_kb has sec_inv; - v23_kf = 0.05; - v23_kf has sec_inv; - v24_ka = 0.01; - v24_ka has nM_per_second; - v24_kb = 400; - v24_kb has nM; - v25_kf = 0.001; - v25_kf has sec_inv; - v26_kf = 0.01; - v26_kf has sec_inv; - v27_kf = 0.0005; - v27_kf has sec_inv; - v28_kf = 0.0005; - v28_kf has sec_inv; - v29_kf = 0.02; - v29_kf has nM_inv_sec_inv; - v29_kb = 0.1; - v29_kb has sec_inv; - v30_kf = 0.008; - v30_kf has nM_inv_sec_inv; - v30_kb = 0.8; - v30_kb has sec_inv; - v31_kf = 0.001; - v31_kf has nM_inv_sec_inv; - v31_kb = 0.2; - v31_kb has sec_inv; - v32_kf = 0.003; - v32_kf has sec_inv; - v33_kf = 0.0005; - v33_kf has sec_inv; - v34_kf = 0.001; - v34_kf has nM_inv_sec_inv; - v34_kb = 0.2; - v34_kb has sec_inv; - v35_kf = 0.008; - v35_kf has nM_inv_sec_inv; - v35_kb = 0.8; - v35_kb has sec_inv; - v36_kf = 0.001; - v36_kf has nM_inv_sec_inv; - v36_kb = 0.2; - v36_kb has sec_inv; - v37_kf = 0.003; - v37_kf has sec_inv; - v38_kf = 0.0005; - v38_kf has sec_inv; - v39_kf = 0.0005; - v39_kf has sec_inv; - v40_kf = 0.003; - v40_kf has sec_inv; - v41_kf = 0.0005; - v41_kf has sec_inv; - v42_kf = 0.02; - v42_kf has nM_inv_sec_inv; - v42_kb = 0.1; - v42_kb has sec_inv; - v43_kf = 0.02; - v43_kf has nM_inv_sec_inv; - v43_kb = 0.1; - v43_kb has sec_inv; - v44_kf = 0.02; - v44_kf has nM_inv_sec_inv; - v44_kb = 0.1; - v44_kb has sec_inv; - v45_kf = 0.02; - v45_kf has nM_inv_sec_inv; - v45_kb = 0.02; - v45_kb has sec_inv; - v46_kf = 0.1; - v46_kf has nM_inv_sec_inv; - v46_kb = 0.05; - v46_kb has sec_inv; - - // Other declarations: - const cytoplasm, nucleus; - - // Unit definitions: - unit substance = 1e-9 mole; - unit nM_per_second = 1e-9 mole / (litre * second); - unit sec_inv = 1 / second; - unit nM_inv_sec_inv = litre / (1e-9 mole * second); - unit nM = 1e-9 mole / litre; - - // Display Names: - substance is "nanomoles"; - R is "Receptor"; - RJ is "Receptor JAK complex"; - IFNRJ is "Interferon-Receptor-JAK complex"; - IFNRJ2 is "IFNRJ dimer"; - IFNRJ2_star is "Activated IFNRJ complex"; - v1 is "Receptor-JAK Binding"; - v2 is "Interferon-Receptor Binding"; - v3 is "IFN-Receptor complex dimerization"; - v4 is "INF-Receptor complex activation"; - v5 is "Activated INFRJ2-STAT1c binding"; - v6 is "STAT1c activation"; - v7 is "Activated IFNRJ2-STAT1c binding"; - v8 is "Activated STAT1c dimerization"; - v9 is "SHP2 binding"; - v10 is "IFNJR2 dephosphorylation"; - v11 is "Phosphorylated STAT1c-PPX binding"; - v12 is "STAT1c dephosphorylation"; - v13 is "PPX binding"; - v14 is "STAT1c dimer dephosphorylation"; - v15 is "STAT1c-phosphorylated STAT1c binding"; - v16 is "STAT1c-nuclear transport"; - v17 is "Phosphorylated STAT1n dimerization"; - v18 is "PPN binding"; - v19 is "STAT1n dephosphorylation"; - v20 is "PPN binding"; - v21 is "STAT1n dephosphorylation"; - v22 is "STAT1n-phosphorylated STAT1n dimerization"; - v23 is "STAT1n transport to cytoplasm"; - v24 is "Transcription"; - v25 is "mRNA transport to cytoplasm"; - v26 is "SOCS1 synthesis"; - v27 is "mRNAc degradation"; - v28 is "SOCS1 degradation"; - v29 is "phosphorylated IFNRJ2-SOCS1 binding"; - v30 is "STAT1c binding"; - v31 is "SHP2 binding"; - v32 is "IFNRJ2 dephosphorylation"; - v33 is "SOCS1 unbinding"; - v34 is "SHP2 binding"; - v35 is "STAT1c binding"; - v36 is "SHP2 binding"; - v38 is "SOCS1 unbinding"; - v39 is "SOCS1 unbinding"; - v40 is "IFNRJ2 dephosphorylation"; - v41 is "SOCS1 unbinding"; - v42 is "SOCS1 binding"; - v43 is "SOCS1 binding"; - v44 is "SOCS1 binding"; - v45 is "Interferon-receptor binding"; - v46 is "IFNR-JAK binding"; - - // CV terms: - cytoplasm identity "http://identifiers.org/obo.go/GO:0005737" - nucleus identity "http://identifiers.org/obo.go/GO:0005634" - R identity "http://identifiers.org/uniprot/O88507" - JAK identity "http://identifiers.org/uniprot/P52332", - "http://identifiers.org/interpro/IPR009127" - RJ part "http://identifiers.org/uniprot/P52332", - "http://identifiers.org/uniprot/O88507" - IFNRJ part "http://identifiers.org/uniprot/P52332", - "http://identifiers.org/uniprot/O88507", - "http://identifiers.org/uniprot/P01572" - IFNRJ2 part "http://identifiers.org/uniprot/P52332", - "http://identifiers.org/uniprot/O88507", - "http://identifiers.org/uniprot/P01572" - IFNRJ2_star part "http://identifiers.org/uniprot/P52332", - "http://identifiers.org/uniprot/O88507", - "http://identifiers.org/uniprot/P01572" - STAT1c identity "http://identifiers.org/uniprot/P42225", - "http://identifiers.org/interpro/IPR001217" - IFNRJ2_star_STAT1c part "http://identifiers.org/uniprot/P42225", - "http://identifiers.org/uniprot/P52332", - "http://identifiers.org/uniprot/O88507", - "http://identifiers.org/uniprot/P01572" - STAT1c_star identity "http://identifiers.org/uniprot/P42225" - IFNRJ2_star_STAT1c_star part "http://identifiers.org/uniprot/P42225", - "http://identifiers.org/uniprot/P52332", - "http://identifiers.org/uniprot/O88507", - "http://identifiers.org/uniprot/P01572" - STAT1c_star_STAT1c_star identity "http://identifiers.org/uniprot/P42225" - SHP2 identity "http://identifiers.org/uniprot/P35235", - "http://identifiers.org/interpro/IPR000980" - IFNRJ2_star_SHP2 part "http://identifiers.org/uniprot/P35235", - "http://identifiers.org/uniprot/P52332", - "http://identifiers.org/uniprot/O88507", - "http://identifiers.org/uniprot/P01572" - STAT1c_star_PPX part "http://identifiers.org/uniprot/P42225" - STAT1c_STAT1c_star identity "http://identifiers.org/uniprot/P42225" - STAT1n_star_STAT1n_star identity "http://identifiers.org/uniprot/P42225" - STAT1n_star identity "http://identifiers.org/uniprot/P42225" - STAT1n_star_PPN part "http://identifiers.org/uniprot/P42225" - STAT1n identity "http://identifiers.org/uniprot/P42225" - STAT1n_STAT1n_star identity "http://identifiers.org/uniprot/P42225" - mRNAn identity "http://identifiers.org/obo.chebi/CHEBI:33699", - "http://identifiers.org/kegg.compound/C00046" - mRNAc identity "http://identifiers.org/obo.chebi/CHEBI:33699", - "http://identifiers.org/kegg.compound/C00046" - SOCS1 identity "http://identifiers.org/uniprot/O35716", - "http://identifiers.org/interpro/IPR001496" - IFNRJ2_star_SOCS1 part "http://identifiers.org/uniprot/O35716", - "http://identifiers.org/uniprot/P52332", - "http://identifiers.org/uniprot/O88507", - "http://identifiers.org/uniprot/P01572" - IFNRJ2_star_SHP2_SOCS1_STAT1c part "http://identifiers.org/uniprot/P42225", - "http://identifiers.org/uniprot/O35716", - "http://identifiers.org/uniprot/P35235", - "http://identifiers.org/uniprot/P52332", - "http://identifiers.org/uniprot/O88507", - "http://identifiers.org/uniprot/P01572" - STAT1c_star_STAT1c_star_PPX part "http://identifiers.org/uniprot/P42225" - STAT1n_star_STAT1n_star_PPN part "http://identifiers.org/uniprot/P42225" - IFNRJ2_star_SOCS1_STAT1c part "http://identifiers.org/uniprot/P42225", - "http://identifiers.org/uniprot/O35716", - "http://identifiers.org/uniprot/P52332", - "http://identifiers.org/uniprot/O88507", - "http://identifiers.org/uniprot/P01572" - IFN identity "http://identifiers.org/uniprot/P01572" - IFNRJ2_star_SHP2_STAT1c part "http://identifiers.org/uniprot/P42225", - "http://identifiers.org/uniprot/P35235", - "http://identifiers.org/uniprot/P52332", - "http://identifiers.org/uniprot/O88507", - "http://identifiers.org/uniprot/P01572" - IFNRJ2_star_SHP2_SOCS1 part "http://identifiers.org/uniprot/O35716", - "http://identifiers.org/uniprot/P35235", - "http://identifiers.org/uniprot/P52332", - "http://identifiers.org/uniprot/O88507", - "http://identifiers.org/uniprot/P01572" - IFNR identity "http://identifiers.org/uniprot/O88507", - "http://identifiers.org/uniprot/P01572" - v1 identity "http://identifiers.org/obo.go/GO:0005133", - "http://identifiers.org/obo.go/GO:0005515" - v2 identity "http://identifiers.org/obo.go/GO:0004906", - "http://identifiers.org/obo.go/GO:0019964" - v3 identity "http://identifiers.org/obo.go/GO:0007171" - v4 identity "http://identifiers.org/ec-code/2.7.10.2", - "http://identifiers.org/kegg.reaction/R02584", - "http://identifiers.org/obo.go/GO:0004713" - v5 identity "http://identifiers.org/obo.go/GO:0005515" - v6 identity "http://identifiers.org/ec-code/2.7.10.2", - "http://identifiers.org/obo.go/GO:0007260" - v7 identity "http://identifiers.org/obo.go/GO:0005515" - v8 identity "http://identifiers.org/obo.go/GO:0007261" - v9 identity "http://identifiers.org/obo.go/GO:0019902", - "http://identifiers.org/obo.go/GO:0005515" - v10 identity "http://identifiers.org/ec-code/3.1.3.48", - "http://identifiers.org/kegg.reaction/R02585", - "http://identifiers.org/obo.go/GO:0005001" - v11 identity "http://identifiers.org/obo.go/GO:0019902", - "http://identifiers.org/obo.go/GO:0005515" - v12 identity "http://identifiers.org/obo.go/GO:0042512" - v13 identity "http://identifiers.org/obo.go/GO:0019902" - v14 identity "http://identifiers.org/obo.go/GO:0042512" - v15 identity "http://identifiers.org/obo.go/GO:0005515" - v16 identity "http://identifiers.org/obo.go/GO:0007262" - v17 identity "http://identifiers.org/obo.go/GO:0007261" - v18 identity "http://identifiers.org/obo.go/GO:0019902" - v19 identity "http://identifiers.org/obo.go/GO:0042512" - v20 identity "http://identifiers.org/obo.go/GO:0019902" - v21 identity "http://identifiers.org/obo.go/GO:0042512" - v22 identity "http://identifiers.org/obo.go/GO:0007261" - v23 identity "http://identifiers.org/obo.go/GO:0065002" - v24 identity "http://identifiers.org/obo.go/GO:0006351" - v25 identity "http://identifiers.org/obo.go/GO:0006406" - v26 identity "http://identifiers.org/obo.go/GO:0006412" - v27 identity "http://identifiers.org/obo.go/GO:0006402" - v28 identity "http://identifiers.org/obo.go/GO:0044257" - v29 identity "http://identifiers.org/obo.go/GO:0005515" - v30 identity "http://identifiers.org/obo.go/GO:0005515" - v31 identity "http://identifiers.org/obo.go/GO:0005515", - "http://identifiers.org/obo.go/GO:0019902" - v32 identity "http://identifiers.org/obo.go/GO:0005001" - v34 identity "http://identifiers.org/obo.go/GO:0019902" - v35 identity "http://identifiers.org/obo.go/GO:0005515" - v36 identity "http://identifiers.org/obo.go/GO:0019902" - v37 identity "http://identifiers.org/obo.go/GO:0043624" - v40 identity "http://identifiers.org/obo.go/GO:0005001", - "http://identifiers.org/obo.go/GO:0043624" - v42 identity "http://identifiers.org/obo.go/GO:0005515" - v43 identity "http://identifiers.org/obo.go/GO:0005515" - v44 identity "http://identifiers.org/obo.go/GO:0005515" - v45 identity "http://identifiers.org/obo.go/GO:0019964", - "http://identifiers.org/obo.go/GO:0004906" - v46 identity "http://identifiers.org/obo.go/GO:0005515", - "http://identifiers.org/obo.go/GO:0005133" -end - -Yamada2003_JAK_STAT_Pathway is "Yamada2003_JAK_STAT_pathway" - -Yamada2003_JAK_STAT_Pathway model_entity_is "http://identifiers.org/biomodels.db/MODEL4879478021" -Yamada2003_JAK_STAT_Pathway model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000093" -Yamada2003_JAK_STAT_Pathway description "http://identifiers.org/pubmed/12527385" -Yamada2003_JAK_STAT_Pathway identity "http://identifiers.org/kegg.pathway/mmu04630", - "http://identifiers.org/obo.go/GO:0007259" -Yamada2003_JAK_STAT_Pathway taxon "http://identifiers.org/taxonomy/10090" diff --git a/BioModelsRAG/data/BIOMD0000000094.txt b/BioModelsRAG/data/BIOMD0000000094.txt deleted file mode 100644 index 8bd3f41f1632803523ac3fe9ce19c38d6c16e003..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000094.txt +++ /dev/null @@ -1,450 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Yamada2003_JAK_STAT_SOCS1_knockout() - - // Compartments and Species: - compartment cytoplasm, nucleus; - species R in cytoplasm, JAK in cytoplasm, RJ in cytoplasm, IFNRJ in cytoplasm; - species IFNRJ2 in cytoplasm, IFNRJ2_star in cytoplasm, STAT1c in cytoplasm; - species IFNRJ2_star_STAT1c in cytoplasm, STAT1c_star in cytoplasm, IFNRJ2_star_STAT1c_star in cytoplasm; - species STAT1c_star_STAT1c_star in cytoplasm, SHP2 in cytoplasm, IFNRJ2_star_SHP2 in cytoplasm; - species PPX in cytoplasm, STAT1c_star_PPX in cytoplasm, STAT1c_STAT1c_star in cytoplasm; - species STAT1n_star_STAT1n_star in nucleus, STAT1n_star in nucleus, PPN in nucleus; - species STAT1n_star_PPN in nucleus, STAT1n in nucleus, STAT1n_STAT1n_star in nucleus; - species mRNAn in nucleus, mRNAc in cytoplasm, SOCS1 in cytoplasm, IFNRJ2_star_SOCS1 in cytoplasm; - species IFNRJ2_star_SHP2_SOCS1_STAT1c in cytoplasm, STAT1c_star_STAT1c_star_PPX in cytoplasm; - species STAT1n_star_STAT1n_star_PPN in nucleus, IFNRJ2_star_SOCS1_STAT1c in cytoplasm; - species $IFN in cytoplasm, IFNRJ2_star_SHP2_STAT1c in cytoplasm, IFNRJ2_star_SHP2_SOCS1 in cytoplasm; - species IFNR in cytoplasm; - - // Reactions: - v1: JAK + R => RJ; cytoplasm*(v1_kf*R*JAK - v1_kb*RJ); - v2: RJ + $IFN => IFNRJ; cytoplasm*(v2_kf*IFN*RJ - v2_kb*IFNRJ); - v3: 2 IFNRJ => IFNRJ2; cytoplasm*(v3_kf*IFNRJ*IFNRJ - v3_kb*IFNRJ2); - v4: IFNRJ2 => IFNRJ2_star; cytoplasm*v4_kf*IFNRJ2; - v5: IFNRJ2_star + STAT1c => IFNRJ2_star_STAT1c; cytoplasm*(v5_kf*STAT1c*IFNRJ2_star - v5_kb*IFNRJ2_star_STAT1c); - v6: IFNRJ2_star_STAT1c => STAT1c_star + IFNRJ2_star; cytoplasm*v6_kf*IFNRJ2_star_STAT1c; - v7: STAT1c_star + IFNRJ2_star => IFNRJ2_star_STAT1c_star; cytoplasm*(v7_kf*IFNRJ2_star*STAT1c_star - v7_kb*IFNRJ2_star_STAT1c_star); - v8: 2 STAT1c_star => STAT1c_star_STAT1c_star; cytoplasm*(v8_kf*STAT1c_star*STAT1c_star - v8_kb*STAT1c_star_STAT1c_star); - v9: SHP2 + IFNRJ2_star => IFNRJ2_star_SHP2; cytoplasm*(v9_kf*IFNRJ2_star*SHP2 - v9_kb*IFNRJ2_star_SHP2); - v10: IFNRJ2_star_SHP2 => SHP2 + IFNRJ2; cytoplasm*v10_kf*IFNRJ2_star_SHP2; - v11: STAT1c_star + PPX => STAT1c_star_PPX; cytoplasm*(v11_kf*PPX*STAT1c_star - v11_kb*STAT1c_star_PPX); - v12: STAT1c_star_PPX => STAT1c + PPX; cytoplasm*v12_kf*STAT1c_star_PPX; - v13: STAT1c_star_STAT1c_star + PPX => STAT1c_star_STAT1c_star_PPX; cytoplasm*(v13_kf*PPX*STAT1c_star_STAT1c_star - v13_kb*STAT1c_star_STAT1c_star_PPX); - v14: STAT1c_star_STAT1c_star_PPX => STAT1c_STAT1c_star + PPX; cytoplasm*v14_kf*STAT1c_star_STAT1c_star_PPX; - v15: STAT1c_star + STAT1c => STAT1c_STAT1c_star; cytoplasm*(v15_kf*STAT1c*STAT1c_star - v15_kb*STAT1c_STAT1c_star); - v16: STAT1c_star_STAT1c_star => STAT1n_star_STAT1n_star; cytoplasm*v16_kf*STAT1c_star_STAT1c_star; - v17: 2 STAT1n_star => STAT1n_star_STAT1n_star; nucleus*(v17_kf*STAT1n_star*STAT1n_star - v17_kb*STAT1n_star_STAT1n_star); - v18: STAT1n_star + PPN => STAT1n_star_PPN; nucleus*(v18_kf*PPN*STAT1n_star - v18_kb*STAT1n_star_PPN); - v19: STAT1n_star_PPN => STAT1n + PPN; nucleus*v19_kf*STAT1n_star_PPN; - v20: STAT1n_star_STAT1n_star + PPN => STAT1n_star_STAT1n_star_PPN; nucleus*(v20_kf*PPN*STAT1n_star_STAT1n_star - v20_kb*STAT1n_star_STAT1n_star_PPN); - v21: STAT1n_star_STAT1n_star_PPN => STAT1n_STAT1n_star + PPN; nucleus*v21_kf*STAT1n_star_STAT1n_star_PPN; - v22: STAT1n_star + STAT1n => STAT1n_STAT1n_star; nucleus*(v22_kf*STAT1n*STAT1n_star - v22_kb*STAT1n_STAT1n_star); - v23: STAT1n => STAT1c; nucleus*v23_kf*STAT1n; - v25: mRNAn => mRNAc; nucleus*v25_kf*mRNAn; - v26: => SOCS1; cytoplasm*v26_kf*mRNAc; - v27: mRNAc => ; cytoplasm*v27_kf*mRNAc; - v28: SOCS1 => ; cytoplasm*v28_kf*SOCS1; - v29: IFNRJ2_star + SOCS1 => IFNRJ2_star_SOCS1; cytoplasm*(v29_kf*SOCS1*IFNRJ2_star - v29_kb*IFNRJ2_star_SOCS1); - v30: IFNRJ2_star_SOCS1 + STAT1c => IFNRJ2_star_SOCS1_STAT1c; cytoplasm*(v30_kf*STAT1c*IFNRJ2_star_SOCS1 - v30_kb*IFNRJ2_star_SOCS1_STAT1c); - v31: IFNRJ2_star_SOCS1_STAT1c + SHP2 => IFNRJ2_star_SHP2_SOCS1_STAT1c; cytoplasm*(v31_kf*SHP2*IFNRJ2_star_SOCS1_STAT1c - v31_kb*IFNRJ2_star_SHP2_SOCS1_STAT1c); - v32: IFNRJ2_star_SHP2_SOCS1_STAT1c => IFNRJ2 + SOCS1 + STAT1c + SHP2; nucleus*v32_kf*IFNRJ2_star_SHP2_SOCS1_STAT1c; - v33: IFNRJ2_star_SHP2_SOCS1_STAT1c => IFNRJ2_star_SHP2_STAT1c; cytoplasm*v33_kf*IFNRJ2_star_SHP2_SOCS1_STAT1c; - v34: IFNRJ2_star_SOCS1 + SHP2 => IFNRJ2_star_SHP2_SOCS1; cytoplasm*(v34_kf*SHP2*IFNRJ2_star_SOCS1 - v34_kb*IFNRJ2_star_SHP2_SOCS1); - v35: IFNRJ2_star_SHP2_SOCS1 + STAT1c => IFNRJ2_star_SHP2_SOCS1_STAT1c; cytoplasm*(v35_kf*STAT1c*IFNRJ2_star_SHP2_SOCS1 - v35_kb*IFNRJ2_star_SHP2_SOCS1_STAT1c); - v36: IFNRJ2_star_STAT1c + SHP2 => IFNRJ2_star_SHP2_STAT1c; cytoplasm*(v36_kf*SHP2*IFNRJ2_star_STAT1c - v36_kb*IFNRJ2_star_SHP2_STAT1c); - v37: IFNRJ2_star_SHP2_STAT1c => STAT1c + SHP2 + IFNRJ2; cytoplasm*v37_kf*IFNRJ2_star_SHP2_STAT1c; - v38: IFNRJ2_star_SOCS1_STAT1c => IFNRJ2_star_STAT1c; cytoplasm*v38_kf*IFNRJ2_star_SOCS1_STAT1c; - v39: IFNRJ2_star_SHP2_SOCS1 => IFNRJ2_star_SHP2; cytoplasm*v39_kf*IFNRJ2_star_SHP2_SOCS1; - v40: IFNRJ2_star_SHP2_SOCS1 => SHP2 + IFNRJ2 + SOCS1; cytoplasm*v40_kf*IFNRJ2_star_SHP2_SOCS1; - v41: IFNRJ2_star_SOCS1 => IFNRJ2_star; cytoplasm*v41_kf*IFNRJ2_star_SOCS1; - v42: IFNRJ2_star_STAT1c + SOCS1 => IFNRJ2_star_SOCS1_STAT1c; cytoplasm*(v42_kf*SOCS1*IFNRJ2_star_STAT1c - v42_kb*IFNRJ2_star_SOCS1_STAT1c); - v43: IFNRJ2_star_SHP2 + SOCS1 => IFNRJ2_star_SHP2_SOCS1; cytoplasm*(v43_kf*SOCS1*IFNRJ2_star_SHP2 - v43_kb*IFNRJ2_star_SHP2_SOCS1); - v44: IFNRJ2_star_SHP2_STAT1c + SOCS1 => IFNRJ2_star_SHP2_SOCS1_STAT1c; cytoplasm*(v44_kf*SOCS1*IFNRJ2_star_SHP2_STAT1c - v44_kb*IFNRJ2_star_SHP2_SOCS1_STAT1c); - v45: R + $IFN => IFNR; cytoplasm*(v45_kf*IFN*R - v45_kb*IFNR); - v46: JAK + IFNR => IFNRJ; cytoplasm*(v46_kf*IFNR*JAK - v46_kb*IFNRJ); - - // Species initializations: - R = 10; - JAK = 10; - RJ = 0; - IFNRJ = 0; - IFNRJ2 = 0; - IFNRJ2_star = 0; - STAT1c = 1000; - IFNRJ2_star_STAT1c = 0; - STAT1c_star = 0; - IFNRJ2_star_STAT1c_star = 0; - STAT1c_star_STAT1c_star = 0; - SHP2 = 100; - IFNRJ2_star_SHP2 = 0; - PPX = 50; - STAT1c_star_PPX = 0; - STAT1c_STAT1c_star = 0; - STAT1n_star_STAT1n_star = 0; - STAT1n_star = 0; - PPN = 60; - STAT1n_star_PPN = 0; - STAT1n = 0; - STAT1n_STAT1n_star = 0; - mRNAn = 0; - mRNAc = 0; - SOCS1 = 0; - IFNRJ2_star_SOCS1 = 0; - IFNRJ2_star_SHP2_SOCS1_STAT1c = 0; - STAT1c_star_STAT1c_star_PPX = 0; - STAT1n_star_STAT1n_star_PPN = 0; - IFNRJ2_star_SOCS1_STAT1c = 0; - IFN = 10; - IFNRJ2_star_SHP2_STAT1c = 0; - IFNRJ2_star_SHP2_SOCS1 = 0; - IFNR = 0; - - // Compartment initializations: - cytoplasm = 1; - nucleus = 1; - - // Variable initializations: - v1_kf = 0.1; - v1_kf has nM_inv_sec_inv; - v1_kb = 0.05; - v1_kb has sec_inv; - v2_kf = 0.02; - v2_kf has nM_inv_sec_inv; - v2_kb = 0.02; - v2_kb has sec_inv; - v3_kf = 0.04; - v3_kf has nM_inv_sec_inv; - v3_kb = 0.2; - v3_kb has sec_inv; - v4_kf = 0.005; - v4_kf has sec_inv; - v5_kf = 0.008; - v5_kf has nM_inv_sec_inv; - v5_kb = 0.8; - v5_kb has sec_inv; - v6_kf = 0.4; - v6_kf has sec_inv; - v7_kf = 0.005; - v7_kf has nM_inv_sec_inv; - v7_kb = 0.5; - v7_kb has sec_inv; - v8_kf = 0.02; - v8_kf has nM_inv_sec_inv; - v8_kb = 0.1; - v8_kb has sec_inv; - v9_kf = 0.001; - v9_kf has nM_inv_sec_inv; - v9_kb = 0.2; - v9_kb has sec_inv; - v10_kf = 0.003; - v10_kf has sec_inv; - v11_kf = 0.001; - v11_kf has nM_inv_sec_inv; - v11_kb = 0.2; - v11_kb has sec_inv; - v12_kf = 0.003; - v12_kf has sec_inv; - v13_kf = 0.001; - v13_kf has nM_inv_sec_inv; - v13_kb = 0.2; - v13_kb has sec_inv; - v14_kf = 0.003; - v14_kf has sec_inv; - v15_kf = 2e-07; - v15_kf has nM_inv_sec_inv; - v15_kb = 0.2; - v15_kb has sec_inv; - v16_kf = 0.005; - v16_kf has sec_inv; - v17_kf = 0.02; - v17_kf has nM_inv_sec_inv; - v17_kb = 0.1; - v17_kb has sec_inv; - v18_kf = 0.001; - v18_kf has nM_inv_sec_inv; - v18_kb = 0.2; - v18_kb has sec_inv; - v19_kf = 0.005; - v19_kf has sec_inv; - v20_kf = 0.001; - v20_kf has nM_inv_sec_inv; - v20_kb = 0.2; - v20_kb has sec_inv; - v21_kf = 0.005; - v21_kf has sec_inv; - v22_kf = 2e-07; - v22_kf has nM_inv_sec_inv; - v22_kb = 0.2; - v22_kb has sec_inv; - v23_kf = 0.05; - v23_kf has sec_inv; - v25_kf = 0.001; - v25_kf has sec_inv; - v26_kf = 0.01; - v26_kf has sec_inv; - v27_kf = 0.0005; - v27_kf has sec_inv; - v28_kf = 0.0005; - v28_kf has sec_inv; - v29_kf = 0.02; - v29_kf has nM_inv_sec_inv; - v29_kb = 0.1; - v29_kb has sec_inv; - v30_kf = 0.008; - v30_kf has nM_inv_sec_inv; - v30_kb = 0.8; - v30_kb has sec_inv; - v31_kf = 0.001; - v31_kf has nM_inv_sec_inv; - v31_kb = 0.2; - v31_kb has sec_inv; - v32_kf = 0.003; - v32_kf has sec_inv; - v33_kf = 0.0005; - v33_kf has sec_inv; - v34_kf = 0.001; - v34_kf has nM_inv_sec_inv; - v34_kb = 0.2; - v34_kb has sec_inv; - v35_kf = 0.008; - v35_kf has nM_inv_sec_inv; - v35_kb = 0.8; - v35_kb has sec_inv; - v36_kf = 0.001; - v36_kf has nM_inv_sec_inv; - v36_kb = 0.2; - v36_kb has sec_inv; - v37_kf = 0.003; - v37_kf has sec_inv; - v38_kf = 0.0005; - v38_kf has sec_inv; - v39_kf = 0.0005; - v39_kf has sec_inv; - v40_kf = 0.003; - v40_kf has sec_inv; - v41_kf = 0.0005; - v41_kf has sec_inv; - v42_kf = 0.02; - v42_kf has nM_inv_sec_inv; - v42_kb = 0.1; - v42_kb has sec_inv; - v43_kf = 0.02; - v43_kf has nM_inv_sec_inv; - v43_kb = 0.1; - v43_kb has sec_inv; - v44_kf = 0.02; - v44_kf has nM_inv_sec_inv; - v44_kb = 0.1; - v44_kb has sec_inv; - v45_kf = 0.02; - v45_kf has nM_inv_sec_inv; - v45_kb = 0.02; - v45_kb has sec_inv; - v46_kf = 0.1; - v46_kf has nM_inv_sec_inv; - v46_kb = 0.05; - v46_kb has sec_inv; - - // Other declarations: - const cytoplasm, nucleus; - - // Unit definitions: - unit substance = 1e-9 mole; - unit nM_per_second = 1e-9 mole / (litre * second); - unit sec_inv = 1 / second; - unit nM_inv_sec_inv = litre / (1e-9 mole * second); - unit nM = 1e-9 mole / litre; - - // Display Names: - substance is "nanomoles"; - R is "Receptor"; - RJ is "Receptor JAK complex"; - IFNRJ is "Interferon-Receptor-JAK complex"; - IFNRJ2 is "IFNRJ dimer"; - IFNRJ2_star is "Activated IFNRJ complex"; - v1 is "Receptor-JAK Binding"; - v2 is "Interferon-Receptor Binding"; - v3 is "IFN-Receptor complex dimerization"; - v4 is "INF-Receptor complex activation"; - v5 is "Activated INFRJ2-STAT1c binding"; - v6 is "STAT1c activation"; - v7 is "Activated IFNRJ2-STAT1c binding"; - v8 is "Activated STAT1c dimerization"; - v9 is "SHP2 binding"; - v10 is "IFNJR2 dephosphorylation"; - v11 is "Phosphorylated STAT1c-PPX binding"; - v12 is "STAT1c dephosphorylation"; - v13 is "PPX binding"; - v14 is "STAT1c dimer dephosphorylation"; - v15 is "STAT1c-phosphorylated STAT1c binding"; - v16 is "STAT1c-nuclear transport"; - v17 is "Phosphorylated STAT1n dimerization"; - v18 is "PPN binding"; - v19 is "STAT1n dephosphorylation"; - v20 is "PPN binding"; - v21 is "STAT1n dephosphorylation"; - v22 is "STAT1n-phosphorylated STAT1n dimerization"; - v23 is "STAT1n transport to cytoplasm"; - v25 is "mRNA transport to cytoplasm"; - v26 is "SOCS1 synthesis"; - v27 is "mRNAc degradation"; - v28 is "SOCS1 degradation"; - v29 is "phosphorylated IFNRJ2-SOCS1 binding"; - v30 is "STAT1c binding"; - v31 is "SHP2 binding"; - v32 is "IFNRJ2 dephosphorylation"; - v33 is "SOCS1 unbinding"; - v34 is "SHP2 binding"; - v35 is "STAT1c binding"; - v36 is "SHP2 binding"; - v38 is "SOCS1 unbinding"; - v39 is "SOCS1 unbinding"; - v40 is "IFNRJ2 dephosphorylation"; - v41 is "SOCS1 unbinding"; - v42 is "SOCS1 binding"; - v43 is "SOCS1 binding"; - v44 is "SOCS1 binding"; - v45 is "Interferon-receptor binding"; - v46 is "IFNR-JAK binding"; - - // CV terms: - cytoplasm identity "http://identifiers.org/go/GO:0005737" - nucleus identity "http://identifiers.org/go/GO:0005634" - R identity "http://identifiers.org/uniprot/P15261", - "http://identifiers.org/interpro/IPR008355" - JAK identity "http://identifiers.org/uniprot/P52332", - "http://identifiers.org/interpro/IPR009127" - RJ part "http://identifiers.org/uniprot/P52332", - "http://identifiers.org/uniprot/P15261" - IFNRJ identity "http://identifiers.org/uniprot/P52332", - "http://identifiers.org/uniprot/P15261", - "http://identifiers.org/uniprot/P01572" - IFNRJ2 part "http://identifiers.org/uniprot/P52332", - "http://identifiers.org/uniprot/P15261", - "http://identifiers.org/uniprot/P01572" - IFNRJ2_star part "http://identifiers.org/uniprot/P52332", - "http://identifiers.org/uniprot/P15261", - "http://identifiers.org/uniprot/P01572" - STAT1c identity "http://identifiers.org/uniprot/P42225", - "http://identifiers.org/interpro/IPR001217" - IFNRJ2_star_STAT1c part "http://identifiers.org/uniprot/P42225", - "http://identifiers.org/uniprot/P52332", - "http://identifiers.org/uniprot/P15261", - "http://identifiers.org/uniprot/P01572" - STAT1c_star identity "http://identifiers.org/uniprot/P42225" - IFNRJ2_star_STAT1c_star part "http://identifiers.org/uniprot/P52332", - "http://identifiers.org/uniprot/P42225", - "http://identifiers.org/uniprot/P01572", - "http://identifiers.org/uniprot/P15261" - STAT1c_star_STAT1c_star identity "http://identifiers.org/uniprot/P42225" - SHP2 identity "http://identifiers.org/uniprot/P35235" - IFNRJ2_star_SHP2 part "http://identifiers.org/uniprot/P35235", - "http://identifiers.org/uniprot/P52332", - "http://identifiers.org/uniprot/P15261", - "http://identifiers.org/uniprot/P01572" - STAT1c_star_PPX part "http://identifiers.org/uniprot/P42225" - STAT1c_STAT1c_star identity "http://identifiers.org/uniprot/P42225" - STAT1n_star_STAT1n_star identity "http://identifiers.org/uniprot/P42225" - STAT1n_star identity "http://identifiers.org/uniprot/P42225" - STAT1n_star_PPN part "http://identifiers.org/uniprot/P42225" - STAT1n identity "http://identifiers.org/uniprot/P42225" - STAT1n_STAT1n_star identity "http://identifiers.org/uniprot/P42225" - mRNAn identity "http://identifiers.org/chebi/CHEBI:33699", - "http://identifiers.org/kegg.compound/C00046" - mRNAc identity "http://identifiers.org/chebi/CHEBI:33699", - "http://identifiers.org/kegg.compound/C00046" - SOCS1 identity "http://identifiers.org/uniprot/O35716", - "http://identifiers.org/interpro/IPR001496" - IFNRJ2_star_SOCS1 part "http://identifiers.org/uniprot/O35716", - "http://identifiers.org/uniprot/P52332", - "http://identifiers.org/uniprot/P15261", - "http://identifiers.org/uniprot/P01572" - IFNRJ2_star_SHP2_SOCS1_STAT1c part "http://identifiers.org/uniprot/P35235", - "http://identifiers.org/uniprot/P42225", - "http://identifiers.org/uniprot/O35716", - "http://identifiers.org/uniprot/P52332", - "http://identifiers.org/uniprot/P15261", - "http://identifiers.org/uniprot/P01572" - STAT1c_star_STAT1c_star_PPX part "http://identifiers.org/uniprot/P42225" - STAT1n_star_STAT1n_star_PPN part "http://identifiers.org/uniprot/P42225" - IFNRJ2_star_SOCS1_STAT1c part "http://identifiers.org/uniprot/P42225", - "http://identifiers.org/uniprot/O35716", - "http://identifiers.org/uniprot/P52332", - "http://identifiers.org/uniprot/P15261", - "http://identifiers.org/uniprot/P01572" - IFN identity "http://identifiers.org/uniprot/P01572" - IFNRJ2_star_SHP2_STAT1c part "http://identifiers.org/uniprot/P35235", - "http://identifiers.org/uniprot/P42225", - "http://identifiers.org/uniprot/P52332", - "http://identifiers.org/uniprot/P15261", - "http://identifiers.org/uniprot/P01572" - IFNRJ2_star_SHP2_SOCS1 part "http://identifiers.org/uniprot/P35235", - "http://identifiers.org/uniprot/O35716", - "http://identifiers.org/uniprot/P52332", - "http://identifiers.org/uniprot/P15261", - "http://identifiers.org/uniprot/P01572" - IFNR part "http://identifiers.org/uniprot/P15261", - "http://identifiers.org/uniprot/P01572" - v1 identity "http://identifiers.org/go/GO:0005515", - "http://identifiers.org/go/GO:0005133" - v2 identity "http://identifiers.org/go/GO:0004906", - "http://identifiers.org/go/GO:0019964" - v3 identity "http://identifiers.org/go/GO:0007171" - v4 identity "http://identifiers.org/ec-code/2.7.10.2", - "http://identifiers.org/kegg.reaction/R02584", - "http://identifiers.org/go/GO:0004713" - v5 identity "http://identifiers.org/go/GO:0005515" - v6 identity "http://identifiers.org/go/GO:0007260" - v7 identity "http://identifiers.org/go/GO:0005515" - v8 identity "http://identifiers.org/go/GO:0007261" - v9 identity "http://identifiers.org/go/GO:0019902" - v10 identity "http://identifiers.org/ec-code/3.1.3.48", - "http://identifiers.org/kegg.reaction/R02585", - "http://identifiers.org/go/GO:0005001" - v11 identity "http://identifiers.org/go/GO:0019902" - v13 identity "http://identifiers.org/go/GO:0019902" - v14 identity "http://identifiers.org/go/GO:0042512" - v15 identity "http://identifiers.org/go/GO:0005515" - v16 identity "http://identifiers.org/go/GO:0007262" - v17 identity "http://identifiers.org/go/GO:0007261" - v18 identity "http://identifiers.org/go/GO:0005515", - "http://identifiers.org/go/GO:0019902" - v19 identity "http://identifiers.org/go/GO:0042512" - v20 identity "http://identifiers.org/go/GO:0019902" - v21 identity "http://identifiers.org/go/GO:0042512" - v22 identity "http://identifiers.org/go/GO:0007261" - v23 identity "http://identifiers.org/go/GO:0065002" - v25 identity "http://identifiers.org/go/GO:0006406" - v26 identity "http://identifiers.org/go/GO:0006412" - v27 identity "http://identifiers.org/go/GO:0006402" - v28 identity "http://identifiers.org/go/GO:0044257" - v29 identity "http://identifiers.org/go/GO:0005515" - v30 identity "http://identifiers.org/go/GO:0005515" - v31 identity "http://identifiers.org/go/GO:0005515", - "http://identifiers.org/go/GO:0019902" - v32 identity "http://identifiers.org/go/GO:0005001" - v34 identity "http://identifiers.org/go/GO:0005515", - "http://identifiers.org/go/GO:0019902" - v35 identity "http://identifiers.org/go/GO:0005515" - v36 identity "http://identifiers.org/go/GO:0005515", - "http://identifiers.org/go/GO:0019902" - v37 identity "http://identifiers.org/go/GO:0043624", - "http://identifiers.org/go/GO:0005001" - v40 identity "http://identifiers.org/go/GO:0005001" - v42 identity "http://identifiers.org/go/GO:0005515" - v43 identity "http://identifiers.org/go/GO:0005515" - v44 identity "http://identifiers.org/go/GO:0005515" - v45 identity "http://identifiers.org/go/GO:0005133", - "http://identifiers.org/go/GO:0019964" - v46 identity "http://identifiers.org/go/GO:0019964" -end - -Yamada2003_JAK_STAT_SOCS1_knockout is "Yamada2003_JAK_STAT_SOCS1_knockout" - -Yamada2003_JAK_STAT_SOCS1_knockout model_entity_is "http://identifiers.org/biomodels.db/MODEL4883413839" -Yamada2003_JAK_STAT_SOCS1_knockout model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000094" -Yamada2003_JAK_STAT_SOCS1_knockout description "http://identifiers.org/pubmed/12527385" -Yamada2003_JAK_STAT_SOCS1_knockout origin "http://identifiers.org/biomodels.db/BIOMD0000000093" -Yamada2003_JAK_STAT_SOCS1_knockout identity "http://identifiers.org/kegg.pathway/mmu04630", - "http://identifiers.org/go/GO:0007259" -Yamada2003_JAK_STAT_SOCS1_knockout taxon "http://identifiers.org/taxonomy/10090" diff --git a/BioModelsRAG/data/BIOMD0000000095.txt b/BioModelsRAG/data/BIOMD0000000095.txt deleted file mode 100644 index ff1de9c54d7deaf716744c41b6a1b4463e62c96a..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000095.txt +++ /dev/null @@ -1,426 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Zeilinger2006_PRR7_PRR9_Y() - - // Compartments and Species: - compartment cytoplasm, nucleus; - species cLc in cytoplasm, cLm in nucleus, cLn in nucleus, cP7c in cytoplasm; - species cP7m in nucleus, cP7n in nucleus, cP9c in cytoplasm, cP9m in nucleus; - species cP9n in nucleus, cPn in nucleus, cTc in cytoplasm, cTm in nucleus; - species cTn in nucleus, cXc in cytoplasm, cXm in nucleus, cXn in nucleus; - species cYc in cytoplasm, cYm in nucleus, cYn in nucleus; - - // Reactions: - R1: => cLm; nucleus*ld*q1*cPn; - R2: => cLm; nucleus*(n1*cXn^a/(g1^a + cXn^a))*(g7^h/(g7^h + cP7n^h))*(g8^i/(g8^i + cP9n^i)); - R3: cLm => ; nucleus*m1*cLm/(k1 + cLm); - R4: => cLc; cytoplasm*p1*cLm; - R5: cLc => cLn; cytoplasm*r1*cLc; - R6: cLn => cLc; nucleus*r2*cLn; - R7: cLc => ; cytoplasm*m2*cLc/(k2 + cLc); - R8: cLn => ; nucleus*m3*cLn/(k3 + cLn); - R9: => cTm; nucleus*(n2*cYn^b/(g2^b + cYn^b))*(g3^c/(g3^c + cLn^c)); - R10: cTm => ; nucleus*m4*cTm/(k4 + cTm); - R11: => cTc; cytoplasm*p2*cTm; - R12: cTc => cTn; cytoplasm*r3*cTc; - R13: cTn => cTc; nucleus*r4*cTn; - R14: cTc => ; cytoplasm*((lmax - ld)*m5 + m6)*(cTc/(k5 + cTc)); - R15: cTn => ; nucleus*((lmax - ld)*m7 + m8)*(cTn/(k6 + cTn)); - R16: => cXm; nucleus*(n3*cTn^d/(g4^d + cTn^d)); - R17: cXm => ; nucleus*(m9*cXm/(k7 + cXm)); - R18: => cXc; cytoplasm*p3*cXm; - R19: cXc => cXn; cytoplasm*r5*cXc; - R20: cXn => cXc; nucleus*r6*cXn; - R21: cXc => ; cytoplasm*m10*cXc/(k8 + cXc); - R22: cXn => ; nucleus*m11*cXn/(k9 + cXn); - R23: => cYm; nucleus*(ld*q2*cPn + (ld*n4 + n5)*g5^e/(g5^e + cTn^e))*(g6^f/(g6^f + cLn^f)); - R24: cYm => ; nucleus*m12*cYm/(k10 + cYm); - R25: => cYc; cytoplasm*p4*cYm; - R26: cYc => cYn; cytoplasm*r7*cYc; - R27: cYn => cYc; nucleus*r8*cYn; - R28: cYc => ; cytoplasm*m13*cYc/(k11 + cYc); - R29: cYn => ; nucleus*m14*cYn/(k12 + cYn); - R30: => cPn; nucleus*(lmax - ld)*p5; - R31a: cPn => ; nucleus*m15*cPn/(k13 + cPn); - R31b: cPn => ; nucleus*q3*ld*cPn; - R32: => cP7m; nucleus*n6*cLn^j/(g9^j + cLn^j); - R33: cP7m => ; nucleus*m16*cP7m/(k14 + cP7m); - R34: => cP7c; cytoplasm*p6*cP7m; - R35: cP7c => cP7n; cytoplasm*r9*cP7c; - R36: cP7n => cP7c; nucleus*r10*cP7n; - R37: cP7c => ; cytoplasm*m17*cP7c/(k15 + cP7c); - R38: cP7n => ; nucleus*m18*cP7n/(k16 + cP7n); - R39: => cP9m; nucleus*n7*cLn^k/(g10^k + cLn^k); - R40: cP9m => ; nucleus*m19*cP9m/(k17 + cP9m); - R41: => cP9c; cytoplasm*p7*cP9m; - R42: cP9c => cP9n; cytoplasm*r11*cP9c; - R43: cP9n => cP9c; nucleus*r12*cP9n; - R44: cP9c => ; cytoplasm*m20*cP9c/(k18 + cP9c); - R45: cP9n => ; nucleus*m21*cP9n/(k19 + cP9n); - - // Events: - event_0000001: at time > 30: ld = 1; - - // Species initializations: - cLc = 6.7846; - cLm = 0.8539; - cLn = 6.8104; - cP7c = 20.0554; - cP7m = 4.28; - cP7n = 2.091; - cP9c = 6.0091; - cP9m = 1.1006; - cP9n = 3.7528; - cPn = 0; - cTc = 0.1724; - cTm = 0.3717; - cTn = 8.0398; - cXc = 13.0372; - cXm = 8.487; - cXn = 31.8995; - cYc = 7.075; - cYm = 0.1937; - cYn = 1.07; - - // Compartment initializations: - cytoplasm = 1; - nucleus = 1; - - // Variable initializations: - ld = 0; - ld has dimensionless; - q1 = 13.1446; - q1 has Hr_inv; - n1 = 1.0988; - n1 has nM_per_hour; - g1 = 11.7992; - g1 has nM; - m1 = 3.7622; - m1 has nM_per_hour; - k1 = 4.1029; - k1 has nM; - p1 = 7.5408; - p1 has Hr_inv; - r1 = 9.9378; - r1 has Hr_inv; - r2 = 9.6442; - r2 has Hr_inv; - m2 = 22.5198; - m2 has nM_per_hour; - k2 = 29.5681; - k2 has nM; - m3 = 4.5545; - m3 has nM_per_hour; - k3 = 18.6335; - k3 has nM; - n2 = 13.5067; - n2 has nM_per_hour; - g2 = 8.733; - g2 has nM; - g3 = 17.9887; - g3 has nM; - m4 = 7.1601; - m4 has nM_per_hour; - k4 = 4.7728; - k4 has nM; - p2 = 1.4452; - p2 has Hr_inv; - p3 = 3.1473; - p3 has Hr_inv; - r5 = 31.0081; - r5 has Hr_inv; - r6 = 12.5039; - r6 has Hr_inv; - m10 = 35.1982; - m10 has nM_per_hour; - k8 = 9.5343; - k8 has nM; - m11 = 7.0274; - m11 has nM_per_hour; - k9 = 45.1336; - k9 has nM; - q2 = 12.7437; - q2 has Hr_inv; - n4 = 1.8828; - n4 has nM_per_hour; - n5 = 1.506; - n5 has nM_per_hour; - g5 = 1.5091; - g5 has nM; - g6 = 20.7577; - g6 has nM; - m12 = 3.4563; - m12 has nM_per_hour; - k10 = 16.4042; - k10 has nM; - r3 = 14.7607; - r3 has Hr_inv; - r4 = 0.2559; - r4 has Hr_inv; - m5 = 1.5511; - m5 has nM_per_hour; - m6 = 1.4189; - m6 has nM_per_hour; - k5 = 3.0204; - k5 has nM; - m7 = 1.6789; - m7 has nM_per_hour; - m8 = 11.3548; - m8 has nM_per_hour; - k6 = 55.3798; - k6 has nM; - n3 = 1.7236; - n3 has nM_per_hour; - g4 = 5.6552; - g4 has nM; - m9 = 5.7847; - m9 has nM_per_hour; - k7 = 29.3208; - k7 has nM; - p4 = 2.8599; - p4 has Hr_inv; - r7 = 5.735; - r7 has Hr_inv; - r8 = 37.3301; - r8 has Hr_inv; - m13 = 9.1535; - m13 has nM_per_hour; - k11 = 55.7326; - k11 has nM; - m14 = 7.5549; - m14 has nM_per_hour; - k12 = 9.0406; - k12 has nM; - p5 = 0.5; - p5 has nM_per_hour; - k13 = 1.2; - k13 has nM; - q3 = 1; - q3 has Hr_inv; - m15 = 1.2; - m15 has nM_per_hour; - g7 = 4.6434; - g7 has nM; - g8 = 4.7985; - g8 has nM; - n6 = 4.6039; - n6 has nM_per_hour; - g9 = 4.8052; - g9 has nM; - m16 = 10.1357; - m16 has nM_per_hour; - k14 = 14.0306; - k14 has nM; - p6 = 2.0248; - p6 has Hr_inv; - r9 = 3.2996; - r9 has Hr_inv; - r10 = 30.7684; - r10 has Hr_inv; - m17 = 7.2481; - m17 has nM_per_hour; - k15 = 19.799; - k15 has nM; - m18 = 7.8275; - m18 has nM_per_hour; - k16 = 8.7977; - k16 has nM; - n7 = 4.4383; - n7 has nM_per_hour; - g10 = 17.7951; - g10 has nM; - m19 = 10.1288; - m19 has nM_per_hour; - k17 = 16.0706; - k17 has nM; - p7 = 1.0929; - p7 has Hr_inv; - r11 = 9.7804; - r11 has Hr_inv; - r12 = 15.4577; - r12 has Hr_inv; - m20 = 0.5315; - m20 has nM_per_hour; - k18 = 48.4999; - k18 has nM; - m21 = 8.5942; - m21 has nM_per_hour; - k19 = 57.4671; - k19 has nM; - lmax = 1; - lmax has dimensionless; - a = 1.8775; - a has dimensionless; - b = 1.5408; - b has dimensionless; - c = 1.4723; - c has dimensionless; - d = 4.0627; - d has dimensionless; - e = 3.5723; - e has dimensionless; - f = 2.0127; - f has dimensionless; - h = 3.3286; - h has dimensionless; - i = 3.5898; - i has dimensionless; - j = 1.269; - j has dimensionless; - k = 1.5212; - k has dimensionless; - - // Other declarations: - var ld; - const cytoplasm, nucleus, q1, n1, g1, m1, k1, p1, r1, r2, m2, k2, m3, k3; - const n2, g2, g3, m4, k4, p2, p3, r5, r6, m10, k8, m11, k9, q2, n4, n5; - const g5, g6, m12, k10, r3, r4, m5, m6, k5, m7, m8, k6, n3, g4, m9, k7; - const p4, r7, r8, m13, k11, m14, k12, p5, k13, q3, m15, g7, g8, n6, g9; - const m16, k14, p6, r9, r10, m17, k15, m18, k16, n7, g10, m19, k17, p7; - const r11, r12, m20, k18, m21, k19, lmax, a, b, c, d, e, f, h, i, j, k; - - // Unit definitions: - unit substance = 1e-9 mole; - unit time_unit = 3600 second; - unit Hr_inv = 1 / 3600 second; - unit nM = 1e-9 mole / litre; - unit nM_per_hour = 1e-9 mole / (litre * 3600 second); - - // Display Names: - substance is "nanomoles"; - time_unit is "hour"; - Hr_inv is "Hour_inv"; - R1 is "Light dependent cLm transcription"; - R2 is "Light independent cLm transcription"; - R3 is "cLm degradation"; - R4 is "cLc synthesis"; - R5 is "cLc transport into nucleus"; - R6 is "cLn transport into cytoplasm"; - R7 is "cLc degradation"; - R8 is "cLn degradation"; - R9 is "cTm transcription"; - R10 is "cTm degradation"; - R11 is "cTc synthesis"; - R12 is "cTc transport into nucleus"; - R13 is "cTn transport into cytoplasm"; - R14 is "cTc degradation"; - R15 is "cTn degradation"; - R16 is "cXm transcription"; - R17 is "cXm degradation"; - R18 is "cXc synthesis"; - R19 is "cXc transport into nucleus"; - R20 is "cXn transport into cytoplasm"; - R21 is "cXc degradation"; - R22 is "cXn degradation"; - R23 is "cYm transcription"; - R24 is "cYm degradation"; - R25 is "cYc synthesis"; - R26 is "cYc transport to nucleus"; - R27 is "cYn transport to cytoplasm"; - R28 is "cYc degradation"; - R29 is "cYn degradation"; - R30 is "cPn synthesis"; - R31a is "cPn degradation"; - R31b is "Light dependent cPn degradation"; - R32 is "cP7m transcription"; - R33 is "cP7m degradation"; - R34 is "cP7c synthesis"; - R35 is "cP7c transport to nucleus"; - R36 is "cP7n transport to cytoplasm"; - R37 is "cP7c degradation"; - R38 is "cP7n degradation"; - R39 is "cP9m transcription"; - R40 is "cP9m degradation"; - R41 is "cP9c synthesis"; - R42 is "cP9c transport to nucleus"; - R43 is "cP9n transport to cytoplasm"; - R44 is "cP9c degradation"; - R45 is "cP9n degradation"; - - // CV terms: - cytoplasm identity "http://identifiers.org/obo.go/GO:0005737" - nucleus identity "http://identifiers.org/obo.go/GO:0005634" - cLc identity "http://identifiers.org/uniprot/O81713" - cLm hypernym "http://identifiers.org/obo.chebi/CHEBI:33699", - "http://identifiers.org/kegg.compound/C00046" - cLn identity "http://identifiers.org/uniprot/O81713" - cP7c identity "http://identifiers.org/uniprot/Q93WK5" - cP7m hypernym "http://identifiers.org/obo.chebi/CHEBI:33699", - "http://identifiers.org/kegg.compound/C00046" - cP7n identity "http://identifiers.org/uniprot/Q93WK5" - cP9c identity "http://identifiers.org/uniprot/Q8L500" - cP9m hypernym "http://identifiers.org/obo.chebi/CHEBI:33699", - "http://identifiers.org/kegg.compound/C00046" - cP9n identity "http://identifiers.org/uniprot/Q8L500" - cTc identity "http://identifiers.org/uniprot/Q9LKL2", - "http://identifiers.org/interpro/IPR010402" - cTm hypernym "http://identifiers.org/obo.chebi/CHEBI:33699", - "http://identifiers.org/kegg.compound/C00046" - cTn identity "http://identifiers.org/uniprot/Q9LKL2", - "http://identifiers.org/interpro/IPR010402" - cXm hypernym "http://identifiers.org/obo.chebi/CHEBI:33699", - "http://identifiers.org/kegg.compound/C00046" - cXn identity "http://identifiers.org/obo.go/GO:0005667" - cYm hypernym "http://identifiers.org/obo.chebi/CHEBI:33699", - "http://identifiers.org/kegg.compound/C00046" - cYn identity "http://identifiers.org/obo.go/GO:0005667" - R1 identity "http://identifiers.org/obo.go/GO:0006351", - "http://identifiers.org/obo.go/GO:0009642" - R2 identity "http://identifiers.org/obo.go/GO:0006351" - R3 identity "http://identifiers.org/obo.go/GO:0006402" - R4 identity "http://identifiers.org/obo.go/GO:0006412" - R5 identity "http://identifiers.org/obo.go/GO:0000060" - R6 identity "http://identifiers.org/obo.go/GO:0065002" - R7 identity "http://identifiers.org/obo.go/GO:0044257" - R8 identity "http://identifiers.org/obo.go/GO:0044257" - R9 identity "http://identifiers.org/obo.go/GO:0006351" - R10 identity "http://identifiers.org/obo.go/GO:0006402" - R11 identity "http://identifiers.org/obo.go/GO:0006412" - R12 identity "http://identifiers.org/obo.go/GO:0000060" - R13 identity "http://identifiers.org/obo.go/GO:0065002" - R14 identity "http://identifiers.org/obo.go/GO:0044257" - R15 identity "http://identifiers.org/obo.go/GO:0044257" - R16 identity "http://identifiers.org/obo.go/GO:0006351" - R17 identity "http://identifiers.org/obo.go/GO:0006402" - R18 identity "http://identifiers.org/obo.go/GO:0006412" - R19 identity "http://identifiers.org/obo.go/GO:0000060" - R20 identity "http://identifiers.org/obo.go/GO:0065002" - R21 identity "http://identifiers.org/obo.go/GO:0044257" - R22 identity "http://identifiers.org/obo.go/GO:0044257" - R23 identity "http://identifiers.org/obo.go/GO:0006351" - R23 part "http://identifiers.org/obo.go/GO:0009642" - R24 identity "http://identifiers.org/obo.go/GO:0006402" - R25 identity "http://identifiers.org/obo.go/GO:0006412" - R26 identity "http://identifiers.org/obo.go/GO:0000060" - R27 identity "http://identifiers.org/obo.go/GO:0065002" - R28 identity "http://identifiers.org/obo.go/GO:0044257" - R29 identity "http://identifiers.org/obo.go/GO:0044257" - R30 identity "http://identifiers.org/obo.go/GO:0009642", - "http://identifiers.org/obo.go/GO:0006412" - R31a identity "http://identifiers.org/obo.go/GO:0044257" - R31b identity "http://identifiers.org/obo.go/GO:0045732", - "http://identifiers.org/obo.go/GO:0009642" - R32 identity "http://identifiers.org/obo.go/GO:0006351" - R33 identity "http://identifiers.org/obo.go/GO:0006402" - R34 identity "http://identifiers.org/obo.go/GO:0006412" - R35 identity "http://identifiers.org/obo.go/GO:0000060" - R36 identity "http://identifiers.org/obo.go/GO:0065002" - R37 identity "http://identifiers.org/obo.go/GO:0044257" - R38 identity "http://identifiers.org/obo.go/GO:0044257" - R39 identity "http://identifiers.org/obo.go/GO:0006351" - R40 identity "http://identifiers.org/obo.go/GO:0006402" - R41 identity "http://identifiers.org/obo.go/GO:0006412" - R42 identity "http://identifiers.org/obo.go/GO:0000060" - R43 identity "http://identifiers.org/obo.go/GO:0065002" - R44 identity "http://identifiers.org/obo.go/GO:0044257" - R45 identity "http://identifiers.org/obo.go/GO:0044257" -end - -Zeilinger2006_PRR7_PRR9_Y is "Zeilinger2006_PRR7-PRR9-Y" - -Zeilinger2006_PRR7_PRR9_Y model_entity_is "http://identifiers.org/biomodels.db/MODEL4025663985" -Zeilinger2006_PRR7_PRR9_Y model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000095" -Zeilinger2006_PRR7_PRR9_Y description "http://identifiers.org/pubmed/17102803" -Zeilinger2006_PRR7_PRR9_Y origin "http://identifiers.org/biomodels.db/BIOMD0000000055" -Zeilinger2006_PRR7_PRR9_Y taxon "http://identifiers.org/taxonomy/3701" -Zeilinger2006_PRR7_PRR9_Y identity "http://identifiers.org/kegg.pathway/ath04710", - "http://identifiers.org/obo.go/GO:0007623" diff --git a/BioModelsRAG/data/BIOMD0000000096.txt b/BioModelsRAG/data/BIOMD0000000096.txt deleted file mode 100644 index 7f37680cb663dbac0c077ef8d38492df5a453dcf..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000096.txt +++ /dev/null @@ -1,434 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Zeilinger2006_PRR7_PRR9light_Y() - - // Compartments and Species: - compartment cytoplasm, nucleus; - species cLc in cytoplasm, cLm in nucleus, cLn in nucleus, cP7c in cytoplasm; - species cP7m in nucleus, cP7n in nucleus, cP9c in cytoplasm, cP9m in nucleus; - species cP9n in nucleus, cPn in nucleus, cTc in cytoplasm, cTm in nucleus; - species cTn in nucleus, cXc in cytoplasm, cXm in nucleus, cXn in nucleus; - species cYc in cytoplasm, cYm in nucleus, cYn in nucleus; - - // Reactions: - R1: => cLm; nucleus*ld*q1*cPn; - R2: => cLm; nucleus*(n1*cXn^a/(g1^a + cXn^a))*(g7^h/(g7^h + cP7n^h))*(g8^i/(g8^i + cP9n^i)); - R3: cLm => ; nucleus*m1*cLm/(k1 + cLm); - R4: => cLc; cytoplasm*p1*cLm; - R5: cLc => cLn; cytoplasm*r1*cLc; - R6: cLn => cLc; nucleus*r2*cLn; - R7: cLc => ; cytoplasm*m2*cLc/(k2 + cLc); - R8: cLn => ; nucleus*m3*cLn/(k3 + cLn); - R9: => cTm; nucleus*(n2*cYn^b/(g2^b + cYn^b))*(g3^c/(g3^c + cLn^c)); - R10: cTm => ; nucleus*m4*cTm/(k4 + cTm); - R11: => cTc; cytoplasm*p2*cTm; - R12: cTc => cTn; cytoplasm*r3*cTc; - R13: cTn => cTc; nucleus*r4*cTn; - R14: cTc => ; cytoplasm*((lmax - ld)*m5 + m6)*(cTc/(k5 + cTc)); - R15: cTn => ; nucleus*((lmax - ld)*m7 + m8)*(cTn/(k6 + cTn)); - R16: => cXm; nucleus*(n3*cTn^d/(g4^d + cTn^d)); - R17: cXm => ; nucleus*(m9*cXm/(k7 + cXm)); - R18: => cXc; cytoplasm*p3*cXm; - R19: cXc => cXn; cytoplasm*r5*cXc; - R20: cXn => cXc; nucleus*r6*cXn; - R21: cXc => ; cytoplasm*m10*cXc/(k8 + cXc); - R22: cXn => ; nucleus*m11*cXn/(k9 + cXn); - R23: => cYm; nucleus*(ld*q2*cPn + (ld*n4 + n5)*g5^e/(g5^e + cTn^e))*(g6^f/(g6^f + cLn^f)); - R24: cYm => ; nucleus*m12*cYm/(k10 + cYm); - R25: => cYc; cytoplasm*p4*cYm; - R26: cYc => cYn; cytoplasm*r7*cYc; - R27: cYn => cYc; nucleus*r8*cYn; - R28: cYc => ; cytoplasm*m13*cYc/(k11 + cYc); - R29: cYn => ; nucleus*m14*cYn/(k12 + cYn); - R30: => cPn; nucleus*(lmax - ld)*p5; - R31a: cPn => ; nucleus*m15*cPn/(k13 + cPn); - R31b: cPn => ; nucleus*q3*ld*cPn; - R32: => cP7m; nucleus*n6*cLn^j/(g9^j + cLn^j); - R33: cP7m => ; nucleus*m16*cP7m/(k14 + cP7m); - R34: => cP7c; cytoplasm*p6*cP7m; - R35: cP7c => cP7n; cytoplasm*r9*cP7c; - R36: cP7n => cP7c; nucleus*r10*cP7n; - R37: cP7c => ; cytoplasm*m17*cP7c/(k15 + cP7c); - R38: cP7n => ; nucleus*m18*cP7n/(k16 + cP7n); - R39: => cP9m; (ld*q4*cPn + n7*ld + n8)*cLn^k/(g10^k + cLn^k); - R40: cP9m => ; nucleus*m19*cP9m/(k17 + cP9m); - R41: => cP9c; cytoplasm*p7*cP9m; - R42: cP9c => cP9n; cytoplasm*r11*cP9c; - R43: cP9n => cP9c; nucleus*r12*cP9n; - R44: cP9c => ; cytoplasm*m20*cP9c/(k18 + cP9c); - R45: cP9n => ; nucleus*m21*cP9n/(k19 + cP9n); - - // Events: - event_0000001: at (Day_in_hours - time) <= 0: ld = 1, Day_in_hours = Day_in_hours + 24; - event_0000002: at ((Day_in_hours - time) <= 12) && ((Day_in_hours - time) > 0): ld = 0; - - // Species initializations: - cLc = 0.0731; - cLm = 0.1114; - cLn = 0.2366; - cP7c = 0.0266; - cP7m = 0.0204; - cP7n = 1.5103; - cP9c = 0.734; - cP9m = 0.002; - cP9n = 1.1162; - cPn = 0; - cTc = 5.2235; - cTm = 3.6732; - cTn = 4.5333; - cXc = 2.4188; - cXm = 0.652; - cXn = 14.7289; - cYc = 49.2611; - cYm = 0.2992; - cYn = 17.4355; - - // Compartment initializations: - cytoplasm = 1; - nucleus = 1; - - // Variable initializations: - Day_in_hours = 24; - Day_in_hours has time_unit; - ld = 1; - ld has dimensionless; - q1 = 7.9798; - q1 has Hr_inv; - n1 = 2.3023; - n1 has nM_per_hour; - g1 = 16.3389; - g1 has nM; - m1 = 8.0568; - m1 has nM_per_hour; - k1 = 22.3951; - k1 has nM; - p1 = 1.2294; - p1 has Hr_inv; - r1 = 31.5166; - r1 has Hr_inv; - r2 = 9.1138; - r2 has Hr_inv; - m2 = 10.4609; - m2 has nM_per_hour; - k2 = 32.7881; - k2 has nM; - m3 = 12.7853; - m3 has nM_per_hour; - k3 = 29.0823; - k3 has nM; - n2 = 7.5433; - n2 has nM_per_hour; - g2 = 16.7487; - g2 has nM; - g3 = 11.5922; - g3 has nM; - m4 = 8.5185; - m4 has nM_per_hour; - k4 = 4.0551; - k4 has nM; - p2 = 1.0494; - p2 has Hr_inv; - p3 = 8.583; - p3 has Hr_inv; - r5 = 27.818; - r5 has Hr_inv; - r6 = 4.2863; - r6 has Hr_inv; - m10 = 9.2511; - m10 has nM_per_hour; - k8 = 13.4324; - k8 has nM; - m11 = 7.9066; - m11 has nM_per_hour; - k9 = 14.605; - k9 has nM; - q2 = 2.5505; - q2 has Hr_inv; - n4 = 1.5293; - n4 has nM_per_hour; - n5 = 2.6296; - n5 has nM_per_hour; - g5 = 0.5061; - g5 has nM; - g6 = 7.8469; - g6 has nM; - m12 = 8.4753; - m12 has nM_per_hour; - k10 = 16.1162; - k10 has nM; - r3 = 29.4222; - r3 has Hr_inv; - r4 = 33.6178; - r4 has Hr_inv; - m5 = 9.3024; - m5 has nM_per_hour; - m6 = 10.899; - m6 has nM_per_hour; - k5 = 16.9133; - k5 has nM; - m7 = 0.7527; - m7 has nM_per_hour; - m8 = 13.7459; - m8 has nM_per_hour; - k6 = 43.7049; - k6 has nM; - n3 = 0.6703; - n3 has nM_per_hour; - g4 = 11.3625; - g4 has nM; - m9 = 2.6345; - m9 has nM_per_hour; - k7 = 8.6873; - k7 has nM; - p4 = 14.6828; - p4 has Hr_inv; - r7 = 9.1917; - r7 has Hr_inv; - r8 = 25.8963; - r8 has Hr_inv; - m13 = 6.8544; - m13 has nM_per_hour; - k11 = 48.5862; - k11 has nM; - m14 = 3.2581; - m14 has nM_per_hour; - k12 = 23.2876; - k12 has nM; - p5 = 0.5; - p5 has nM_per_hour; - k13 = 1.2; - k13 has nM; - q3 = 1; - q3 has Hr_inv; - m15 = 1.2; - m15 has nM_per_hour; - g7 = 0.4444; - g7 has nM; - g8 = 11.0459; - g8 has nM; - n6 = 11.3117; - n6 has nM_per_hour; - g9 = 14.5219; - g9 has nM; - m16 = 9.531; - m16 has nM_per_hour; - k14 = 50.9418; - k14 has nM; - p6 = 6.7738; - p6 has Hr_inv; - r9 = 31.0318; - r9 has Hr_inv; - r10 = 0.4557; - r10 has Hr_inv; - m17 = 5.4062; - m17 has nM_per_hour; - k15 = 49.4094; - k15 has nM; - m18 = 8.671; - m18 has nM_per_hour; - k16 = 42.4837; - k16 has nM; - n7 = 0.0833; - n7 has nM_per_hour; - g10 = 5.6855; - g10 has nM; - m19 = 6.1155; - m19 has nM_per_hour; - k17 = 18.6089; - k17 has nM; - p7 = 10.4532; - p7 has Hr_inv; - r11 = 34.6266; - r11 has Hr_inv; - r12 = 22.838; - r12 has Hr_inv; - m20 = 3.4152; - m20 has nM_per_hour; - k18 = 16.2407; - k18 has nM; - m21 = 0.028; - m21 has nM_per_hour; - k19 = 26.5795; - k19 has nM; - q4 = 7.4548; - q4 has Hr_inv; - n8 = 2.0738; - n8 has nM; - lmax = 1; - lmax has dimensionless; - a = 2.2802; - a has dimensionless; - b = 3.1075; - b has dimensionless; - c = 1.6808; - c has dimensionless; - d = 1.0164; - d has dimensionless; - e = 1.4943; - e has dimensionless; - f = 1.9491; - f has dimensionless; - h = 2.2116; - h has dimensionless; - i = 1.1065; - i has dimensionless; - j = 2.5579; - j has dimensionless; - k = 3.3953; - k has dimensionless; - - // Other declarations: - var Day_in_hours, ld; - const cytoplasm, nucleus, q1, n1, g1, m1, k1, p1, r1, r2, m2, k2, m3, k3; - const n2, g2, g3, m4, k4, p2, p3, r5, r6, m10, k8, m11, k9, q2, n4, n5; - const g5, g6, m12, k10, r3, r4, m5, m6, k5, m7, m8, k6, n3, g4, m9, k7; - const p4, r7, r8, m13, k11, m14, k12, p5, k13, q3, m15, g7, g8, n6, g9; - const m16, k14, p6, r9, r10, m17, k15, m18, k16, n7, g10, m19, k17, p7; - const r11, r12, m20, k18, m21, k19, q4, n8, lmax, a, b, c, d, e, f, h, i; - const j, k; - - // Unit definitions: - unit substance = 1e-9 mole; - unit time_unit = 3600 second; - unit Hr_inv = 1 / 3600 second; - unit nM = 1e-9 mole / litre; - unit nM_per_hour = 1e-9 mole / (litre * 3600 second); - - // Display Names: - substance is "nanomoles"; - time_unit is "hour"; - Hr_inv is "Hour_inv"; - R1 is "Light dependent cLm synthesis"; - R2 is "Light independent cLm synthesis"; - R3 is "cLm degradation"; - R4 is "cLc synthesis"; - R5 is "cLc transport into nucleus"; - R6 is "cLn transport into cytoplasm"; - R7 is "cLc degradation"; - R8 is "cLn degradation"; - R9 is "cTm transcription"; - R10 is "cTm degradation"; - R11 is "cTc synthesis"; - R12 is "cTc transport into nucleus"; - R13 is "cTn transport into cytoplasm"; - R14 is "cTc degradation"; - R15 is "cTn degradation"; - R16 is "cXm transcription"; - R17 is "cXm degradation"; - R18 is "cXc transcription"; - R19 is "cXc transport into nucleus"; - R20 is "cXn transport into cytoplasm"; - R21 is "cXc degradation"; - R22 is "cXn degradation"; - R23 is "cYm transcription"; - R24 is "cYm degradation"; - R25 is "cYc transcription"; - R26 is "cYc transport to nucleus"; - R27 is "cYn transport to cytoplasm"; - R28 is "cYc degradation"; - R29 is "cYn degradation"; - R30 is "cPn synthesis"; - R31a is "cPn degradation"; - R31b is "Light dependent cPn degradation"; - R32 is "cP7m transcription"; - R33 is "cP7m degradation"; - R34 is "cP7c synthesis"; - R35 is "cP7c transport to nucleus"; - R36 is "cP7n transport to cytoplasm"; - R37 is "cP7c degradation"; - R38 is "cP7n degradation"; - R39 is "cP9m transcription"; - R40 is "cP79m degradation"; - R41 is "cP9c synthesis"; - R42 is "cP9c transport to nucleus"; - R43 is "cP9n transport to cytoplasm"; - R44 is "cP9c degradation"; - R45 is "cP9n degradation"; - - // CV terms: - cytoplasm identity "http://identifiers.org/obo.go/GO:0005737" - nucleus identity "http://identifiers.org/obo.go/GO:0005634" - cLc identity "http://identifiers.org/uniprot/O81713" - cLm identity "http://identifiers.org/obo.chebi/CHEBI:33699", - "http://identifiers.org/kegg.compound/C00046" - cLn identity "http://identifiers.org/uniprot/O81713" - cP7c identity "http://identifiers.org/uniprot/Q93WK5" - cP7m identity "http://identifiers.org/obo.chebi/CHEBI:33699", - "http://identifiers.org/kegg.compound/C00046" - cP7n identity "http://identifiers.org/uniprot/Q93WK5" - cP9c identity "http://identifiers.org/uniprot/Q8L500" - cP9m identity "http://identifiers.org/obo.chebi/CHEBI:33699", - "http://identifiers.org/kegg.compound/C00046" - cP9n identity "http://identifiers.org/uniprot/Q8L500" - cTc identity "http://identifiers.org/uniprot/Q9LKL2", - "http://identifiers.org/interpro/IPR010402" - cTm identity "http://identifiers.org/obo.chebi/CHEBI:33699", - "http://identifiers.org/kegg.compound/C00046" - cTn identity "http://identifiers.org/uniprot/Q9LKL2" - cXm identity "http://identifiers.org/obo.chebi/CHEBI:33699", - "http://identifiers.org/kegg.compound/C00046" - cXn identity "http://identifiers.org/obo.go/GO:0005667" - cYm identity "http://identifiers.org/obo.chebi/CHEBI:33699", - "http://identifiers.org/kegg.compound/C00046" - cYn identity "http://identifiers.org/obo.go/GO:0005667" - R1 identity "http://identifiers.org/obo.go/GO:0006351", - "http://identifiers.org/obo.go/GO:0009642" - R2 identity "http://identifiers.org/obo.go/GO:0006351" - R3 identity "http://identifiers.org/obo.go/GO:0006402" - R4 identity "http://identifiers.org/obo.go/GO:0006412" - R5 identity "http://identifiers.org/obo.go/GO:0000060" - R6 identity "http://identifiers.org/obo.go/GO:0065002" - R7 identity "http://identifiers.org/obo.go/GO:0044257" - R8 identity "http://identifiers.org/obo.go/GO:0044257" - R9 identity "http://identifiers.org/obo.go/GO:0006351" - R10 identity "http://identifiers.org/obo.go/GO:0006402" - R11 identity "http://identifiers.org/obo.go/GO:0006412" - R12 identity "http://identifiers.org/obo.go/GO:0000060" - R13 identity "http://identifiers.org/obo.go/GO:0065002" - R14 identity "http://identifiers.org/obo.go/GO:0044257" - R15 identity "http://identifiers.org/obo.go/GO:0044257" - R16 identity "http://identifiers.org/obo.go/GO:0006351" - R17 identity "http://identifiers.org/obo.go/GO:0006402" - R18 identity "http://identifiers.org/obo.go/GO:0006412" - R19 identity "http://identifiers.org/obo.go/GO:0000060" - R20 identity "http://identifiers.org/obo.go/GO:0065002" - R21 identity "http://identifiers.org/obo.go/GO:0044257" - R22 identity "http://identifiers.org/obo.go/GO:0044257" - R23 identity "http://identifiers.org/obo.go/GO:0006351", - "http://identifiers.org/obo.go/GO:0009642" - R24 identity "http://identifiers.org/obo.go/GO:0006402" - R25 identity "http://identifiers.org/obo.go/GO:0006412" - R26 identity "http://identifiers.org/obo.go/GO:0000060" - R27 identity "http://identifiers.org/obo.go/GO:0065002" - R28 identity "http://identifiers.org/obo.go/GO:0044257" - R29 identity "http://identifiers.org/obo.go/GO:0044257" - R30 identity "http://identifiers.org/obo.go/GO:0009642", - "http://identifiers.org/obo.go/GO:0006412" - R31a identity "http://identifiers.org/obo.go/GO:0044257" - R31b identity "http://identifiers.org/obo.go/GO:0045732", - "http://identifiers.org/obo.go/GO:0009642" - R32 identity "http://identifiers.org/obo.go/GO:0006351" - R33 identity "http://identifiers.org/obo.go/GO:0006402" - R34 identity "http://identifiers.org/obo.go/GO:0006412" - R35 identity "http://identifiers.org/obo.go/GO:0000060" - R36 identity "http://identifiers.org/obo.go/GO:0065002" - R37 identity "http://identifiers.org/obo.go/GO:0044257" - R38 identity "http://identifiers.org/obo.go/GO:0044257" - R39 identity "http://identifiers.org/obo.go/GO:0006351" - R39 part "http://identifiers.org/obo.go/GO:0009642" - R40 identity "http://identifiers.org/obo.go/GO:0006402" - R41 identity "http://identifiers.org/obo.go/GO:0006412" - R42 identity "http://identifiers.org/obo.go/GO:0000060" - R43 identity "http://identifiers.org/obo.go/GO:0065002" - R44 identity "http://identifiers.org/obo.go/GO:0044257" - R45 identity "http://identifiers.org/obo.go/GO:0044257" -end - -Zeilinger2006_PRR7_PRR9light_Y is "Zeilinger2006_PRR7-PRR9light-Y" - -Zeilinger2006_PRR7_PRR9light_Y model_entity_is "http://identifiers.org/biomodels.db/MODEL4025634026" -Zeilinger2006_PRR7_PRR9light_Y model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000096" -Zeilinger2006_PRR7_PRR9light_Y description "http://identifiers.org/pubmed/17102803" -Zeilinger2006_PRR7_PRR9light_Y origin "http://identifiers.org/biomodels.db/BIOMD0000000055" -Zeilinger2006_PRR7_PRR9light_Y identity "http://identifiers.org/kegg.pathway/ath04710", - "http://identifiers.org/obo.go/GO:0007623" -Zeilinger2006_PRR7_PRR9light_Y taxon "http://identifiers.org/taxonomy/3701" diff --git a/BioModelsRAG/data/BIOMD0000000097.txt b/BioModelsRAG/data/BIOMD0000000097.txt deleted file mode 100644 index d3611e516a82791b2838d7d51597ef9d9e211a36..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000097.txt +++ /dev/null @@ -1,431 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Zeilinger2006_PRR7_PRR9light_Yprime() - - // Compartments and Species: - compartment cytoplasm, nucleus; - species cLc in cytoplasm, cLm in nucleus, cLn in nucleus, cP7c in cytoplasm; - species cP7m in nucleus, cP7n in nucleus, cP9c in cytoplasm, cP9m in nucleus; - species cP9n in nucleus, cPn in nucleus, cTc in cytoplasm, cTm in nucleus; - species cTn in nucleus, cXc in cytoplasm, cXm in nucleus, cXn in nucleus; - species cYc in cytoplasm, cYm in nucleus, cYn in nucleus; - - // Reactions: - R1: => cLm; nucleus*ld*q1*cPn; - R2: => cLm; nucleus*(n1*cXn^a/(g1^a + cXn^a))*(g7^h/(g7^h + cP7n^h))*(g8^i/(g8^i + cP9n^i)); - R3: cLm => ; nucleus*m1*cLm/(k1 + cLm); - R4: => cLc; cytoplasm*p1*cLm; - R5: cLc => cLn; cytoplasm*r1*cLc; - R6: cLn => cLc; nucleus*r2*cLn; - R7: cLc => ; cytoplasm*m2*cLc/(k2 + cLc); - R8: cLn => ; nucleus*m3*cLn/(k3 + cLn); - R9: => cTm; nucleus*(n2*cYn^b/(g2^b + cYn^b))*(g3^c/(g3^c + cLn^c)); - R10: cTm => ; nucleus*m4*cTm/(k4 + cTm); - R11: => cTc; cytoplasm*p2*cTm; - R12: cTc => cTn; cytoplasm*r3*cTc; - R13: cTn => cTc; nucleus*r4*cTn; - R14: cTc => ; cytoplasm*((lmax - ld)*m5 + m6)*(cTc/(k5 + cTc)); - R15: cTn => ; nucleus*((lmax - ld)*m7 + m8)*(cTn/(k6 + cTn)); - R16: => cXm; nucleus*n3*cTn^d/(g4^d + cTn^d); - R17: cXm => ; nucleus*m9*cXm/(k7 + cXm); - R18: => cXc; cytoplasm*p3*cXm; - R19: cXc => cXn; cytoplasm*r5*cXc; - R20: cXn => cXc; nucleus*r6*cXn; - R21: cXc => ; cytoplasm*m10*cXc/(k8 + cXc); - R22: cXn => ; nucleus*m11*cXn/(k9 + cXn); - R23: => cYm; nucleus*((ld*n4 + n5)*g5^e/(g5^e + cTn^e))*(g6^f/(g6^f + cLn^f)); - R24: cYm => ; nucleus*m12*cYm/(k10 + cYm); - R25: => cYc; cytoplasm*p4*cYm; - R26: cYc => cYn; cytoplasm*r7*cYc; - R27: cYn => cYc; nucleus*r8*cYn; - R28: cYc => ; cytoplasm*m13*cYc/(k11 + cYc); - R29: cYn => ; nucleus*m14*cYn/(k12 + cYn); - R30: => cPn; nucleus*(lmax - ld)*p5; - R31a: cPn => ; nucleus*m15*cPn/(k13 + cPn); - R31b: cPn => ; nucleus*q3*ld*cPn; - R32: => cP7m; nucleus*n6*cLn^j/(g9^j + cLn^j); - R33: cP7m => ; nucleus*m16*cP7m/(k14 + cP7m); - R34: => cP7c; cytoplasm*p6*cP7m; - R35: cP7c => cP7n; cytoplasm*r9*cP7c; - R36: cP7n => cP7c; nucleus*r10*cP7n; - R37: cP7c => ; cytoplasm*m17*cP7c/(k15 + cP7c); - R38: cP7n => ; nucleus*m18*cP7n/(k16 + cP7n); - R39: => cP9m; nucleus*((ld*q4*cPn + n7*ld + n8)*cLn^k/(g10^k + cLn^k)); - R40: cP9m => ; nucleus*m19*cP9m/(k17 + cP9m); - R41: => cP9c; cytoplasm*p7*cP9m; - R42: cP9c => cP9n; cytoplasm*r11*cP9c; - R43: cP9n => cP9c; nucleus*r12*cP9n; - R44: cP9c => ; cytoplasm*m20*cP9c/(k18 + cP9c); - R45: cP9n => ; nucleus*m21*cP9n/(k19 + cP9n); - - // Events: - event_0000001: at (Day_in_hours - time) <= 0: ld = 1, Day_in_hours = Day_in_hours + 24; - event_0000002: at ((Day_in_hours - time) <= 16) && ((Day_in_hours - time) > 0): ld = 0; - - // Species initializations: - cLc = 0.0659; - cLm = 0.1951; - cLn = 0.3952; - cP7c = 0.0861; - cP7m = 0.0772; - cP7n = 2.7182; - cP9c = 0.0077; - cP9m = 0.0011; - cP9n = 0.0073; - cPn = 0; - cTc = 0.7852; - cTm = 0.1234; - cTn = 4.5209; - cXc = 2.5615; - cXm = 1.6104; - cXn = 14.5474; - cYc = 7.6795; - cYm = 1.1149; - cYn = 9.7016; - - // Compartment initializations: - cytoplasm = 1; - nucleus = 1; - - // Variable initializations: - Day_in_hours = 24; - Day_in_hours has time_unit; - ld = 1; - ld has dimensionless; - q1 = 13.4334; - q1 has Hr_inv; - n1 = 3.2016; - n1 has nM_per_hour; - g1 = 9.041; - g1 has nM; - m1 = 6.8248; - m1 has nM_per_hour; - k1 = 13.0594; - k1 has nM; - p1 = 0.6926; - p1 has Hr_inv; - r1 = 25.6818; - r1 has Hr_inv; - r2 = 3.9781; - r2 has Hr_inv; - m2 = 9.4099; - m2 has nM_per_hour; - k2 = 30.5639; - k2 has nM; - m3 = 13.7795; - m3 has nM_per_hour; - k3 = 33.514; - k3 has nM; - n2 = 11.6086; - n2 has nM_per_hour; - g2 = 16.6598; - g2 has nM; - g3 = 13.4112; - g3 has nM; - m4 = 12.1232; - m4 has nM_per_hour; - k4 = 1.3722; - k4 has nM; - p2 = 0.5403; - p2 has Hr_inv; - p3 = 6.9124; - p3 has Hr_inv; - r5 = 29.4607; - r5 has Hr_inv; - r6 = 4.5034; - r6 has Hr_inv; - m10 = 8.5523; - m10 has nM_per_hour; - k8 = 12.528; - k8 has nM; - m11 = 23.5996; - m11 has nM_per_hour; - k9 = 15.0626; - k9 has nM; - n4 = 1.7832; - n4 has nM_per_hour; - n5 = 7.4615; - n5 has nM_per_hour; - g5 = 1.5987; - g5 has nM; - g6 = 16.489; - g6 has nM; - m12 = 5.9504; - m12 has nM_per_hour; - k10 = 11.5688; - k10 has nM; - r3 = 51.1965; - r3 has Hr_inv; - r4 = 8.9147; - r4 has Hr_inv; - m5 = 7.2129; - m5 has nM_per_hour; - m6 = 9.5754; - m6 has nM_per_hour; - k5 = 34.2078; - k5 has nM; - m7 = 1.1032; - m7 has nM_per_hour; - m8 = 2.2006; - m8 has nM_per_hour; - k6 = 56.7596; - k6 has nM; - n3 = 2.4751; - n3 has nM_per_hour; - g4 = 20.5277; - g4 has nM; - m9 = 4.2193; - m9 has nM_per_hour; - k7 = 14.9114; - k7 has nM; - p4 = 6.0042; - p4 has Hr_inv; - r7 = 35.7842; - r7 has Hr_inv; - r8 = 27.9229; - r8 has Hr_inv; - m13 = 7.5959; - m13 has nM_per_hour; - k11 = 26.9638; - k11 has nM; - m14 = 8.1796; - m14 has nM_per_hour; - k12 = 21.8348; - k12 has nM; - p5 = 0.5; - p5 has nM_per_hour; - k13 = 1.2; - k13 has nM; - q3 = 1; - q3 has Hr_inv; - m15 = 1.2; - m15 has nM_per_hour; - g7 = 0.2778; - g7 has nM; - g8 = 0.9187; - g8 has nM; - n6 = 11.0924; - n6 has nM_per_hour; - g9 = 20.3795; - g9 has nM; - m16 = 9.3186; - m16 has nM_per_hour; - k14 = 51.261; - k14 has nM; - p6 = 9.8416; - p6 has Hr_inv; - r9 = 24.5689; - r9 has Hr_inv; - r10 = 0.5024; - r10 has Hr_inv; - m17 = 3.6143; - m17 has nM_per_hour; - k15 = 32.939; - k15 has nM; - m18 = 6.7455; - m18 has nM_per_hour; - k16 = 24.451; - k16 has nM; - n7 = 0.1031; - n7 has nM_per_hour; - g10 = 5.8418; - g10 has nM; - m19 = 1.9234; - m19 has nM_per_hour; - k17 = 9.8065; - k17 has nM; - p7 = 1.5323; - p7 has Hr_inv; - r11 = 25.7542; - r11 has Hr_inv; - r12 = 27.2451; - r12 has Hr_inv; - m20 = 3.7484; - m20 has nM_per_hour; - k18 = 25.9739; - k18 has nM; - m21 = 0.0193; - m21 has nM_per_hour; - k19 = 21.6441; - k19 has nM; - q4 = 6.274; - q4 has Hr_inv; - n8 = 3.5262; - n8 has nM; - a = 1.2497; - a has dimensionless; - b = 4.2126; - b has dimensionless; - c = 1.4509; - c has dimensionless; - d = 1.3058; - d has dimensionless; - e = 2.4146; - e has dimensionless; - f = 2.1349; - f has dimensionless; - h = 1.4176; - h has dimensionless; - i = 2.0074; - i has dimensionless; - j = 1.7615; - j has dimensionless; - k = 3.8877; - k has dimensionless; - lmax = 1; - lmax has dimensionless; - - // Other declarations: - var Day_in_hours, ld; - const cytoplasm, nucleus, q1, n1, g1, m1, k1, p1, r1, r2, m2, k2, m3, k3; - const n2, g2, g3, m4, k4, p2, p3, r5, r6, m10, k8, m11, k9, n4, n5, g5; - const g6, m12, k10, r3, r4, m5, m6, k5, m7, m8, k6, n3, g4, m9, k7, p4; - const r7, r8, m13, k11, m14, k12, p5, k13, q3, m15, g7, g8, n6, g9, m16; - const k14, p6, r9, r10, m17, k15, m18, k16, n7, g10, m19, k17, p7, r11; - const r12, m20, k18, m21, k19, q4, n8, a, b, c, d, e, f, h, i, j, k, lmax; - - // Unit definitions: - unit substance = 1e-9 mole; - unit time_unit = 3600 second; - unit Hr_inv = 1 / 3600 second; - unit nM = 1e-9 mole / litre; - unit nM_per_hour = 1e-9 mole / (litre * 3600 second); - - // Display Names: - substance is "nanomoles"; - time_unit is "hour"; - Hr_inv is "Hour_inv"; - R1 is "Light dependent cLm production"; - R2 is "Light independent cLm production"; - R3 is "cLm degradation"; - R4 is "cLc synthesis"; - R5 is "cLc transport to nucleus"; - R6 is "cLn transport to cytoplasm"; - R7 is "cLc degradation"; - R8 is "cLn degradation"; - R9 is "cTm transcription"; - R10 is "cTm degradation"; - R11 is "cTc synthesis"; - R12 is "cTc transport to nucleus"; - R13 is "cTn transport to cytoplasm"; - R14 is "cTc degradation"; - R15 is "cTn degradation"; - R16 is "Species X transcription"; - R17 is "Species X degradation"; - R18 is "cXc synthesis"; - R19 is "cXc transport to nucleus"; - R20 is "cXn transport to cytoplasm"; - R21 is "cXc degradation"; - R22 is "cXn degradation"; - R23 is "Species Y transcription"; - R24 is "cYm degradation"; - R25 is "cYc synthesis"; - R26 is "cYc transport to nucleus"; - R27 is "cYn transport to cytoplasm"; - R28 is "cYc degradation"; - R29 is "cYn degradation"; - R30 is "cPn synthesis"; - R31a is "cPn degradation"; - R31b is "cPn light dependent degradation"; - R32 is "cP7m transcription"; - R33 is "cP7m degradation"; - R34 is "cP7c synthesis"; - R35 is "cP7c transport to nucleus"; - R36 is "cP7n transport to cytoplasm"; - R37 is "cP7c degradation"; - R38 is "cP7n degradation"; - R39 is "cP9m transcription"; - R40 is "cP9m degradation"; - R41 is "cP9c synthesis"; - R42 is "cP9c transport to nucleus"; - R43 is "cP9n transport to cytoplasm"; - R44 is "cP9c degradation"; - R45 is "cP9n degradation"; - - // CV terms: - cytoplasm identity "http://identifiers.org/obo.go/GO:0005737" - nucleus identity "http://identifiers.org/obo.go/GO:0005634" - cLc identity "http://identifiers.org/uniprot/O81713" - cLm identity "http://identifiers.org/obo.chebi/CHEBI:33699", - "http://identifiers.org/kegg.compound/C00046" - cLn identity "http://identifiers.org/uniprot/O81713" - cP7c identity "http://identifiers.org/uniprot/Q93WK5" - cP7m identity "http://identifiers.org/obo.chebi/CHEBI:33699", - "http://identifiers.org/kegg.compound/C00046" - cP7n identity "http://identifiers.org/uniprot/Q93WK5" - cP9c identity "http://identifiers.org/uniprot/Q8L500" - cP9m identity "http://identifiers.org/obo.chebi/CHEBI:33699", - "http://identifiers.org/kegg.compound/C00046" - cP9n identity "http://identifiers.org/uniprot/Q8L500" - cTc identity "http://identifiers.org/uniprot/Q9LKL2", - "http://identifiers.org/interpro/IPR010402" - cTm identity "http://identifiers.org/obo.chebi/CHEBI:33699", - "http://identifiers.org/kegg.compound/C00046" - cTn identity "http://identifiers.org/uniprot/Q9LKL2", - "http://identifiers.org/interpro/IPR010402" - cXm identity "http://identifiers.org/obo.chebi/CHEBI:33699", - "http://identifiers.org/kegg.compound/C00046" - cXn identity "http://identifiers.org/obo.go/GO:0005667" - cYm identity "http://identifiers.org/obo.chebi/CHEBI:33699", - "http://identifiers.org/kegg.compound/C00046" - cYn identity "http://identifiers.org/obo.go/GO:0005667" - R1 identity "http://identifiers.org/obo.go/GO:0006351", - "http://identifiers.org/obo.go/GO:0009642" - R2 identity "http://identifiers.org/obo.go/GO:0006351" - R3 identity "http://identifiers.org/obo.go/GO:0006402" - R4 identity "http://identifiers.org/obo.go/GO:0006412" - R5 identity "http://identifiers.org/obo.go/GO:0000060" - R6 identity "http://identifiers.org/obo.go/GO:0065002" - R7 identity "http://identifiers.org/obo.go/GO:0044257" - R8 identity "http://identifiers.org/obo.go/GO:0044257" - R9 identity "http://identifiers.org/obo.go/GO:0006351" - R10 identity "http://identifiers.org/obo.go/GO:0006402" - R11 identity "http://identifiers.org/obo.go/GO:0006412" - R12 identity "http://identifiers.org/obo.go/GO:0000060" - R13 identity "http://identifiers.org/obo.go/GO:0065002" - R14 identity "http://identifiers.org/obo.go/GO:0044257" - R15 identity "http://identifiers.org/obo.go/GO:0044257" - R16 identity "http://identifiers.org/obo.go/GO:0006351" - R17 identity "http://identifiers.org/obo.go/GO:0006402" - R18 identity "http://identifiers.org/obo.go/GO:0006412" - R19 identity "http://identifiers.org/obo.go/GO:0000060" - R20 identity "http://identifiers.org/obo.go/GO:0065002" - R21 identity "http://identifiers.org/obo.go/GO:0044257" - R22 identity "http://identifiers.org/obo.go/GO:0044257" - R23 identity "http://identifiers.org/obo.go/GO:0006351" - R23 part "http://identifiers.org/obo.go/GO:0009642" - R24 identity "http://identifiers.org/obo.go/GO:0006402" - R25 identity "http://identifiers.org/obo.go/GO:0006412" - R26 identity "http://identifiers.org/obo.go/GO:0000060" - R27 identity "http://identifiers.org/obo.go/GO:0065002" - R28 identity "http://identifiers.org/obo.go/GO:0044257" - R29 identity "http://identifiers.org/obo.go/GO:0044257" - R30 identity "http://identifiers.org/obo.go/GO:0009642", - "http://identifiers.org/obo.go/GO:0006412" - R31a identity "http://identifiers.org/obo.go/GO:0044257" - R31b identity "http://identifiers.org/obo.go/GO:0045732", - "http://identifiers.org/obo.go/GO:0009642" - R32 identity "http://identifiers.org/obo.go/GO:0006351" - R33 identity "http://identifiers.org/obo.go/GO:0006402" - R34 identity "http://identifiers.org/obo.go/GO:0006412" - R35 identity "http://identifiers.org/obo.go/GO:0000060" - R36 identity "http://identifiers.org/obo.go/GO:0065002" - R37 identity "http://identifiers.org/obo.go/GO:0044257" - R38 identity "http://identifiers.org/obo.go/GO:0044257" - R39 identity "http://identifiers.org/obo.go/GO:0006351" - R40 identity "http://identifiers.org/obo.go/GO:0006402" - R41 identity "http://identifiers.org/obo.go/GO:0006412" - R42 identity "http://identifiers.org/obo.go/GO:0000060" - R43 identity "http://identifiers.org/obo.go/GO:0065002" - R44 identity "http://identifiers.org/obo.go/GO:0044257" - R45 identity "http://identifiers.org/obo.go/GO:0044257" -end - -Zeilinger2006_PRR7_PRR9light_Yprime is "Zeilinger2006_PRR7-PRR9light-Yprime" - -Zeilinger2006_PRR7_PRR9light_Yprime model_entity_is "http://identifiers.org/biomodels.db/MODEL4025650992" -Zeilinger2006_PRR7_PRR9light_Yprime model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000097" -Zeilinger2006_PRR7_PRR9light_Yprime description "http://identifiers.org/pubmed/17102803" -Zeilinger2006_PRR7_PRR9light_Yprime origin "http://identifiers.org/biomodels.db/BIOMD0000000055" -Zeilinger2006_PRR7_PRR9light_Yprime taxon "http://identifiers.org/taxonomy/3701" -Zeilinger2006_PRR7_PRR9light_Yprime identity "http://identifiers.org/kegg.pathway/ath04710", - "http://identifiers.org/obo.go/GO:0007623" diff --git a/BioModelsRAG/data/BIOMD0000000098.txt b/BioModelsRAG/data/BIOMD0000000098.txt deleted file mode 100644 index 126e6f793ffbba3e9beb8b9e15e8cc3c64db5066..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000098.txt +++ /dev/null @@ -1,96 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Goldbeter1990_CalciumSpike_CICR() - - // Compartments and Species: - compartment cytosol, store; - species Z in cytosol, Y in store; - - // Reactions: - R0: => Z; cytosol*v0; - R1: => Z; cytosol*v1*beta; - R2: Z => Y; cytosol*(Vm2*Z^n/(K2^n + Z^n)); - R3: Y => Z; store*(Vm3*Y^m*Z^p/((Kr^m + Y^m)*(Ka^p + Z^p))); - Rf: Y => Z; store*kf*Y; - R_eff: Z => ; cytosol*k*Z; - - // Species initializations: - Z = 0.15; - Y = 1.6; - - // Compartment initializations: - cytosol = 1; - store = 1; - - // Variable initializations: - v0 = 1; - v0 has uM_per_sec; - v1 = 7.3; - v1 has uM_per_sec; - beta = 0.301; - beta has dimensionless; - Vm2 = 65; - Vm2 has uM_per_sec; - n = 2; - n has dimensionless; - K2 = 1; - K2 has uM; - Vm3 = 500; - Vm3 has uM_per_sec; - m = 2; - m has dimensionless; - Kr = 2; - Kr has uM; - Ka = 0.9; - Ka has uM; - kf = 1; - kf has sec_inv; - k = 10; - k has sec_inv; - p = 4; - p has dimensionless; - - // Other declarations: - const cytosol, store, v0, v1, beta, Vm2, n, K2, Vm3, m, Kr, Ka, kf, k, p; - - // Unit definitions: - unit substance = 1e-6 mole; - unit uM_per_sec = 1e-6 mole / (litre * second); - unit sec_inv = 1 / second; - unit uM = 1e-6 mole / litre; - - // Display Names: - substance is "micromole"; - R0 is "Ca influx"; - R1 is "InsP3 dependent Ca influx"; - R2 is "ATP driven Ca pumping into store"; - R3 is "ATP driven pumping into cytosol"; - Rf is "Ca leak"; - R_eff is "Ca efflux"; - - // CV terms: - cytosol identity "http://identifiers.org/go/GO:0005829" - store identity "http://identifiers.org/go/GO:0005783" - Z identity "http://identifiers.org/chebi/CHEBI:29108", - "http://identifiers.org/kegg.compound/C00076" - Y identity "http://identifiers.org/chebi/CHEBI:29108", - "http://identifiers.org/kegg.compound/C00076" - R0 identity "http://identifiers.org/go/GO:0006816" - R1 identity "http://identifiers.org/go/GO:0005220" - R2 identity "http://identifiers.org/go/GO:0032470" - R3 identity "http://identifiers.org/go/GO:0007204", - "http://identifiers.org/go/GO:0048763" - Rf identity "http://identifiers.org/go/GO:0007204" - R_eff identity "http://identifiers.org/go/GO:0006816" -end - -Goldbeter1990_CalciumSpike_CICR is "Goldbeter1990_CalciumSpike_CICR" - -Goldbeter1990_CalciumSpike_CICR model_entity_is "http://identifiers.org/biomodels.db/MODEL4519937652" -Goldbeter1990_CalciumSpike_CICR model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000098" -Goldbeter1990_CalciumSpike_CICR description "http://identifiers.org/pubmed/2304911" -Goldbeter1990_CalciumSpike_CICR origin "http://identifiers.org/pubmed/6281582" -Goldbeter1990_CalciumSpike_CICR hypernym "http://identifiers.org/go/GO:0005220", - "http://identifiers.org/go/GO:0006816", - "http://identifiers.org/go/GO:0019722" -Goldbeter1990_CalciumSpike_CICR taxon "http://identifiers.org/taxonomy/131567" -Goldbeter1990_CalciumSpike_CICR property "http://identifiers.org/mamo/MAMO_0000046" diff --git a/BioModelsRAG/data/BIOMD0000000099.txt b/BioModelsRAG/data/BIOMD0000000099.txt deleted file mode 100644 index c83d2bcf46bcc033e6cedc9ff6a83ee37b3828f0..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000099.txt +++ /dev/null @@ -1,146 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Model_1() - - // Compartments and Species: - compartment compartment_0, compartment_1; - species species_0 in compartment_0, species_1 in compartment_1, species_2 in compartment_1; - species species_3 in compartment_1, species_4 in compartment_1, species_5 in compartment_1; - species species_6 in compartment_1; - - // Reactions: - reaction_0: => species_4; compartment_1*parameter_0*species_6; - reaction_1: species_4 => ; compartment_1*parameter_1*species_4; - reaction_2: => species_2; compartment_1*parameter_2*species_1; - reaction_3: species_2 => ; compartment_1*parameter_3*species_2; - reaction_4: => species_6; compartment_1*parameter_4*species_5; - reaction_5: species_6 => ; compartment_1*parameter_5*species_6*species_2; - reaction_6: => species_3; compartment_1*parameter_6; - reaction_7: species_3 => ; compartment_1*parameter_7*species_3*species_6; - reaction_8: => species_1; compartment_1*parameter_8*species_4; - reaction_9: species_1 => ; compartment_1*parameter_9*species_1*species_3; - reaction_10: => species_0; compartment_0*parameter_10*species_4; - reaction_11: species_0 => ; compartment_0*parameter_11*species_0; - reaction_12: => species_5; compartment_1*parameter_12*species_0; - reaction_13: species_5 => ; compartment_1*parameter_13*species_5*species_2; - - // Species initializations: - species_0 = 0; - species_1 = 1; - species_2 = 1; - species_3 = 2.5; - species_4 = 1.4; - species_5 = 1.5; - species_6 = 1.6; - - // Compartment initializations: - compartment_0 = 1; - compartment_1 = 1; - - // Variable initializations: - parameter_0 = 1.4; - parameter_1 = 0.9; - parameter_2 = 2.5; - parameter_3 = 1.5; - parameter_4 = 0.6; - parameter_5 = 0.8; - parameter_6 = 2; - parameter_7 = 1.3; - parameter_8 = 0.29; - parameter_9 = 1; - parameter_10 = 0.6; - parameter_11 = 3.1; - parameter_12 = 33; - parameter_13 = 4.5; - - // Other declarations: - const compartment_0, compartment_1, parameter_0, parameter_1, parameter_2; - const parameter_3, parameter_4, parameter_5, parameter_6, parameter_7, parameter_8; - const parameter_9, parameter_10, parameter_11, parameter_12, parameter_13; - - // Unit definitions: - unit time_unit = 60 second; - unit substance = 1e-6 mole; - - // Display Names: - time_unit is "min"; - substance is "micro_Mole"; - compartment_0 is "Extracellular"; - compartment_1 is "Intracellular"; - species_0 is "Ex_cAMP"; - species_1 is "In_cAMP"; - species_2 is "PKA"; - species_3 is "REGA"; - species_4 is "ACA"; - species_5 is "CAR1"; - species_6 is "ERK2"; - parameter_0 is "k1"; - parameter_1 is "k2"; - parameter_2 is "k3"; - parameter_3 is "k4"; - parameter_4 is "k5"; - parameter_5 is "k6"; - parameter_6 is "k7"; - parameter_7 is "k8"; - parameter_8 is "k9"; - parameter_9 is "k10"; - parameter_10 is "k11"; - parameter_11 is "k12"; - parameter_12 is "k13"; - parameter_13 is "k14"; - reaction_0 is "k1"; - reaction_1 is "k2"; - reaction_2 is "k3"; - reaction_3 is "k4"; - reaction_4 is "k5"; - reaction_5 is "k6"; - reaction_6 is "k7"; - reaction_7 is "k8"; - reaction_8 is "k9"; - reaction_9 is "k10"; - reaction_10 is "k11"; - reaction_11 is "k12"; - reaction_12 is "k13"; - reaction_13 is "k14"; - - // CV terms: - compartment_0 hypernym "http://identifiers.org/go/GO:0005576" - compartment_1 hypernym "http://identifiers.org/go/GO:0005623" - species_0 identity "http://identifiers.org/chebi/CHEBI:17489", - "http://identifiers.org/kegg.compound/C00575" - species_1 identity "http://identifiers.org/chebi/CHEBI:17489", - "http://identifiers.org/kegg.compound/C00575" - species_2 identity "http://identifiers.org/uniprot/P34099" - species_2 hypernym "http://identifiers.org/interpro/IPR002373" - species_3 hypernym "http://identifiers.org/interpro/IPR000396" - species_4 hypernym "http://identifiers.org/interpro/IPR008172" - species_5 identity "http://identifiers.org/uniprot/P13773" - species_5 hypernym "http://identifiers.org/interpro/IPR000848" - species_6 hypernym "http://identifiers.org/interpro/IPR008349" - species_6 homolog "http://identifiers.org/uniprot/P28482" - reaction_0 hypernym "http://identifiers.org/go/GO:0004707", - "http://identifiers.org/go/GO:0007190" - reaction_1 hypernym "http://identifiers.org/go/GO:0007194" - reaction_2 hypernym "http://identifiers.org/go/GO:0001646", - "http://identifiers.org/go/GO:0032147" - reaction_3 hypernym "http://identifiers.org/go/GO:0006469" - reaction_4 hypernym "http://identifiers.org/go/GO:0045860" - reaction_5 hypernym "http://identifiers.org/go/GO:0004672" - reaction_7 hypernym "http://identifiers.org/go/GO:0004707" - reaction_8 hypernym "http://identifiers.org/go/GO:0004016", - "http://identifiers.org/go/GO:0030819" - reaction_9 hypernym "http://identifiers.org/go/GO:0004115" - reaction_10 hypernym "http://identifiers.org/go/GO:0004016" - reaction_11 hypernym "http://identifiers.org/go/GO:0006198" - reaction_12 hypernym "http://identifiers.org/go/GO:0001646" - reaction_13 hypernym "http://identifiers.org/ec-code/2.7.11.1", - "http://identifiers.org/go/GO:0004672" -end - -Model_1 is "Laub1998_SpontaneousOscillations" - -Model_1 model_entity_is "http://identifiers.org/biomodels.db/MODEL4515710981" -Model_1 model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000099" -Model_1 description "http://identifiers.org/pubmed/9843585" -Model_1 taxon "http://identifiers.org/taxonomy/5782" -Model_1 property "http://identifiers.org/mamo/MAMO_0000046" -Model_1 hypernym "http://identifiers.org/go/GO:0019933" diff --git a/BioModelsRAG/data/BIOMD0000000100.txt b/BioModelsRAG/data/BIOMD0000000100.txt deleted file mode 100644 index 2e0f804b98ae520aa50510362221fa7d24eaec0c..0000000000000000000000000000000000000000 --- a/BioModelsRAG/data/BIOMD0000000100.txt +++ /dev/null @@ -1,164 +0,0 @@ -// Created by libAntimony v2.13.0 -model *Rozi2003_Glycogen_Phosphorylase_Activation() - - // Compartments and Species: - compartment extracellular, cytosol, intravesicular; - species $EC in extracellular, Z in cytosol, A in cytosol, Y in intravesicular; - species GP in cytosol; - - // Reactions: - vin: $EC => Z; extracellular*(v0 + v1*beta); - R2: Z => Y; cytosol*(Vm2*Z^2/(K2^2 + Z^2)); - R3: Y => Z; intravesicular*Vm3*A^4*Y^2*Z^m/((Ka^4 + A^4)*(Ky^2 + Y^2)*(Kz^m + Z^m)); - Rkf: Y => Z; intravesicular*Kf*Y; - Rkz: Z => $EC; cytosol*K*Z; - R4: => A; cytosol*beta*V4; - R5: A => ; cytosol*Vm5*A^p*Z^n/((K5^p + A^p)*(Kd^n + Z^n)); - R6: A => ; cytosol*epsilon*A; - R7: => GP; cytosol*(Vpm1*(1 + gamma_*Z^4/(Ka5^4 + Z^4))*(1 - GP)/(K1/(1 + Z^4/Ka6^4) + 1 - GP)); - R8: GP => ; cytosol*(Vpm2*(1 + alpha*G/(Ka1 + G))*GP/(Kp2/(1 + G/Ka2) + GP)); - - // Species initializations: - EC = 1000; - Z = 0; - A = 0.45; - Y = 0.36; - GP = 1; - - // Compartment initializations: - extracellular = 1; - cytosol = 1; - intravesicular = 1; - - // Variable initializations: - v0 = 2; - v0 has uM_per_min; - v1 = 2; - v1 has uM_per_min; - beta = 0.5; - beta has dimensionless; - Vm2 = 6; - Vm2 has uM_per_min; - K2 = 0.1; - K2 has uM; - Vm3 = 20; - Vm3 has uM_per_min; - m = 2; - m has dimensionless; - Ka = 0.2; - Ka has uM; - Ky = 0.2; - Ky has uM; - Kz = 0.5; - Kz has uM; - Kf = 1; - Kf has min_inv; - K = 10; - K has min_inv; - V4 = 2; - V4 has uM_per_min; - Vm5 = 30; - Vm5 has uM_per_min; - n = 4; - n has dimensionless; - K5 = 1; - K5 has uM; - Kd = 0.4; - Kd has uM; - epsilon = 0.1; - epsilon has min_inv; - Vpm1 = 1.5; - Vpm1 has min_inv; - gamma_ = 9; - gamma_ has dimensionless; - Ka5 = 0.5; - Ka5 has uM; - K1 = 0.1; - Ka6 = 0.5; - Ka6 has uM; - Vpm2 = 0.6; - Vpm2 has min_inv; - alpha = 9; - alpha has dimensionless; - G = 10000; - G has uM; - Ka1 = 10000; - Ka1 has uM; - Kp2 = 0.2; - Ka2 = 10000; - Ka2 has uM; - p = 2; - p has dimensionless; - - // Other declarations: - const extracellular, cytosol, intravesicular, v0, v1, beta, Vm2, K2, Vm3; - const m, Ka, Ky, Kz, Kf, K, V4, Vm5, n, K5, Kd, epsilon, Vpm1, gamma_, Ka5; - const K1, Ka6, Vpm2, alpha, G, Ka1, Kp2, Ka2, p; - - // Unit definitions: - unit substance = 1e-6 mole; - unit uM = 1e-6 mole / litre; - unit uM_per_min = 1e-6 mole / (litre * 3600 second); - unit time_unit = 3600 second; - unit min_inv = 1 / 3600 second; - - // Display Names: - substance is "micromole"; - time_unit is "minutes"; - EC is "Extracellular Calcium"; - Z is "Cytosolic Calcium"; - A is "IP3"; - Y is "Intravesicular Calcium"; - GP is "Glycogen Phosphorylase"; - vin is "Calcium Influx"; - R2 is "Calcium transport to internal store"; - R3 is "Calcium transport to cytosol"; - Rkf is "Calcium leak"; - Rkz is "Calcium efflux"; - R4 is "Agonist stimulated production of IP3"; - R5 is "Ca-dependant IP3 degradation"; - R6 is "Ca independent IP3 degradation"; - R7 is "Phosphorylase kinase activity"; - R8 is "Phosphatase activity"; - - // CV terms: - extracellular identity "http://identifiers.org/go/GO:0005615" - cytosol identity "http://identifiers.org/go/GO:0005829" - intravesicular hypernym "http://identifiers.org/go/GO:0005783" - EC identity "http://identifiers.org/chebi/CHEBI:29108", - "http://identifiers.org/kegg.compound/C00076" - Z identity "http://identifiers.org/chebi/CHEBI:29108", - "http://identifiers.org/kegg.compound/C00076" - A identity "http://identifiers.org/chebi/CHEBI:16595", - "http://identifiers.org/kegg.compound/C01245" - Y identity "http://identifiers.org/chebi/CHEBI:29108", - "http://identifiers.org/kegg.compound/C00076" - GP hypernym "http://identifiers.org/uniprot/P11216" - vin hypernym "http://identifiers.org/go/GO:0007204", - "http://identifiers.org/go/GO:0006816" - R2 hypernym "http://identifiers.org/go/GO:0032470", - "http://identifiers.org/go/GO:0051481" - R3 hypernym "http://identifiers.org/go/GO:0007204" - Rkf hypernym "http://identifiers.org/go/GO:0007204" - Rkz hypernym "http://identifiers.org/go/GO:0051481" - R4 hypernym "http://identifiers.org/go/GO:0032959" - R5 hypernym "http://identifiers.org/go/GO:0032961" - R6 hypernym "http://identifiers.org/go/GO:0032961" - R7 identity "http://identifiers.org/ec-code/2.7.11.19", - "http://identifiers.org/go/GO:0004689" - R8 identity "http://identifiers.org/ec-code/3.1.3.17", - "http://identifiers.org/go/GO:0050196" -end - -Rozi2003_Glycogen_Phosphorylase_Activation is "Rozi2003_GlycogenPhosphorylase_Activation" - -Rozi2003_Glycogen_Phosphorylase_Activation model_entity_is "http://identifiers.org/biomodels.db/MODEL4589754842" -Rozi2003_Glycogen_Phosphorylase_Activation model_entity_is "http://identifiers.org/biomodels.db/BIOMD0000000100" -Rozi2003_Glycogen_Phosphorylase_Activation description "http://identifiers.org/pubmed/14556891" -Rozi2003_Glycogen_Phosphorylase_Activation origin "http://identifiers.org/pubmed/11093832", - "http://identifiers.org/pubmed/17883229" -Rozi2003_Glycogen_Phosphorylase_Activation taxon "http://identifiers.org/taxonomy/131567" -Rozi2003_Glycogen_Phosphorylase_Activation part "http://identifiers.org/go/GO:0008607" -Rozi2003_Glycogen_Phosphorylase_Activation part "http://identifiers.org/kegg.pathway/hsa04020" -Rozi2003_Glycogen_Phosphorylase_Activation hypernym "http://identifiers.org/go/GO:0019722", - "http://identifiers.org/go/GO:0048016"