text
stringlengths 57
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| relation
stringclasses 125
values | h
dict | t
dict |
|---|---|---|---|
cobalt epilepsy was accompanied by changes in a larger number of amino acids than penicillin epilepsy : in the former the brain content of taurine , gaba , aspartate , glutamate , serine , threonine , glycine and alanine was altered . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
65,
76
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
213,
220
]
} |
in passive eae , the most significant increase occurred only in the lower spinal cord for cathepsins a and c , and fourthly , in monocytic eae induced by tilorone , there was an exceptionally large , 3-fold increase in cathepsin c in lower cord as compared to a 1.5-2 fold increase for other cathepsins . | NA | {
"id": "C0058361",
"name": "cathepsin c",
"pos": [
219,
230
]
} | {
"id": "C0007428",
"name": "cathepsins",
"pos": [
292,
302
]
} |
the results show that drinking and blood pressure response to angiotensin ii can be blocked by p113 ( 500 ng 1.v.t . ) an angiotensin antagonist ; | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
62,
76
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
122,
133
]
} |
extraction of this membrane preparation with sodium iodide or 2,3-dimethylmaleic anhydride solubilized 50 and 70 % of the membrane protein , respectively , resulting from the extensive extraction of protein from all but two of the major membrane polypeptide components . | NA | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
122,
138
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
199,
206
]
} |
in cultures grown on synthetic medium supplemented with l-leucine and l-homoarginine , the metabolit 3-isobuty1-6 ( 4-guanidinobuty1 ) -2- ( 1h ) pyrazinone was found , and in cultures that had been supplemented with l-norleucine and l-arginine , the metabolite 3-buty1-6- ( 3-guanidinopropy1 ) -2 ( 1h ) pyrazinone was found . | NA | {
"id": "C0019877",
"name": "homoarginine",
"pos": [
72,
84
]
} | {
"id": "C0003765",
"name": "l-arginine",
"pos": [
234,
244
]
} |
since the analysis of isolated radioactive-and spin-labelled lipids revealed the exact composition of membrane-bound labelled lipids , specific temperature-induced changes were correlated with specific lipids of examined membranes . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
61,
67
]
} | {
"id": "C0025249",
"name": "lipids",
"pos": [
202,
208
]
} |
antibodies to uveal components or immune complexes containing 'auto-antibodies ' do not appear to be a common source of tissue damage in human endogenous anterior uveitis . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
34,
50
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
68,
78
]
} |
a 45-year-old male with von recklinghausen 's disease was noted to have hamartomatous lesions of the retinae similar to those more commonly described in bourneville 's disease and von hippel-lindau 's disease . | NA | {
"id": "C0018552",
"name": "hamartomatous",
"pos": [
72,
85
]
} | {
"id": "C0041341",
"name": "bourneville 's disease",
"pos": [
153,
175
]
} |
enhancement ( by atp , insulin , and lack of divalent cations ) of ouabain inhibition of cation transport and ouabain binding in frog skeletal muscle ; | NA | {
"id": "C0007448",
"name": "divalent cations",
"pos": [
45,
61
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
89,
95
]
} |
three cases of subcapital fracture of the hip that occurred after an intertochanteric fracture of the femur had been nailed have been described in the literature . | NA | {
"id": "C0019557",
"name": "of",
"pos": [
12,
14
]
} | {
"id": "C0015802",
"name": "fracture of",
"pos": [
86,
97
]
} |
before the infarction her electrocardiogram had been normal at rest but showed ischemia after exercise . | NA | {
"id": "C0021308",
"name": "infarction",
"pos": [
11,
21
]
} | {
"id": "C0022116",
"name": "ischemia",
"pos": [
79,
87
]
} |
while the other tumors had no effect on the plasma level of phenylalanine ammonia-lyase after a single injection , l5178y murine lymphoblastic leukemia and 15091a anaplastic carcinoma significantly depressed the maximal level of phenylalanine ammonia-lyase attained in the plasma . | NA | {
"id": "C0002610",
"name": "ammonia-lyase",
"pos": [
74,
87
]
} | {
"id": "C0031454",
"name": "phenylalanine",
"pos": [
229,
242
]
} |
formaldehyde production in leukocytes is only slightly stimulated by addition of various cobalamins , and activity is normal in leukocytes from a vitamin b12-deficient patient . | NA | {
"id": "C0086024",
"name": "cobalamins",
"pos": [
89,
99
]
} | {
"id": "C0042845",
"name": "vitamin b12",
"pos": [
146,
157
]
} |
the distribution of microfilament bundles in cells was examined using antibodies to fibroblast myosin and indirect immunofluorescence microscopy . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
45,
50
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
84,
94
]
} |
mouse plasmacytoma ( mopc ) 460 cells contain two chromatographic forms of rna polymerase iii ( iiia and iiib ) in addition to the major class i and ii rna polymerases . | NA | {
"id": "C0035680",
"name": "rna",
"pos": [
75,
78
]
} | {
"id": "C0035681",
"name": "rna",
"pos": [
152,
155
]
} |
exogenous rna polymerase iii from xenopus laevis ovaries stimulates 4.5s and 5s rna synthesis in mopc nuclei as effectively as do the mopc class iii rna polymerases . | NA | {
"id": "C0035680",
"name": "rna polymerase iii",
"pos": [
10,
28
]
} | {
"id": "C0035681",
"name": "rna",
"pos": [
149,
152
]
} |
however , exogenous mopc class i and ii rna polymerases do not stimulate 4.5s and 5s rna synthesis , suggesting that this effect is specific for the structurally similar class iii rna polymerases . | NA | {
"id": "C0035681",
"name": "rna polymerases",
"pos": [
40,
55
]
} | {
"id": "C0035680",
"name": "iii rna polymerases",
"pos": [
176,
195
]
} |
the cdna was found to be a full-length transcript of protamine messenger rna and was used as a probe for hybridization reactions with rna preparations isolated from three subcellular compartments of differentiating trout testis cells . | NA | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
63,
76
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
134,
137
]
} |
the resulting dose-response curves indicate that productive infection of a single balb/3t3 cell with n tropic msv requires co-infection with two mulv particles . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
60,
69
]
} | {
"id": "C0275524",
"name": "co-infection",
"pos": [
123,
135
]
} |
a slight , but significant , rise in serum phenobarbitone concentrations was observed during frusemide therapy , but no change was seen in serum primidone or phenytoin concentrations . | NA | {
"id": "C0031412",
"name": "phenobarbitone",
"pos": [
43,
57
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
145,
154
]
} |
in a pharmacokinetic study in six volunteers peak serum mecillinam concentrations were proportional to the oral dose of pivmecillinam at two dose levels of 200 and 400 mg . | NA | {
"id": "C0002435",
"name": "mecillinam",
"pos": [
56,
66
]
} | {
"id": "C0002436",
"name": "pivmecillinam",
"pos": [
120,
133
]
} |
effects of bed rest , probenecid and a 6 day course of treatment with pivmecillinam on serum mecillinam concentrations after an oral dose of pivmecillinam ( two 200 mg capsules ) have been investigated . | NA | {
"id": "C0002435",
"name": "mecillinam",
"pos": [
73,
83
]
} | {
"id": "C0002436",
"name": "pivmecillinam",
"pos": [
141,
154
]
} |
information about drug interactions , adverse reactions , mode of action , absorption , distribution , metabolism , excretion and cost was seldom provided in uk journals . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
103,
113
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
116,
125
]
} |
the formation constants for cationic hydroxymethylamines from cationic amines and formaldehyde ( k2 ) are about two orders of magnitude less favorable than those for the neutral species and , reciprocally , the pk ( a ) 2values of n-hydroxymethylanilinium ions are about two ph units lower than their parent anilinium ions . | NA | {
"id": "C0007447",
"name": "cationic",
"pos": [
28,
36
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
318,
322
]
} |
these range from errors in assessing the patient 's psychological state and the state of their health , through the more common physical sequelae of bleeding with haematoma formation , ectropion , hypertrophy of scars , etc. , to complications affecting the function of the eye itself . | NA | {
"id": "C0019080",
"name": "bleeding",
"pos": [
149,
157
]
} | {
"id": "C0018944",
"name": "haematoma",
"pos": [
163,
172
]
} |
in the guinea pig , some capsules surrounding solid silicone implants , silicone sacs with saline , and silicone sac with silicone gel show vacuole or amorphous materials ( silicone ) with a thickening of the capsule and associated inflammatory reaction . | NA | {
"id": "C0599034",
"name": "silicone",
"pos": [
52,
60
]
} | {
"id": "C0037114",
"name": "silicone",
"pos": [
173,
181
]
} |
these vacuoles or amorphous material resembles the silicone found in capsules around intact human silicone jell prosthesis . | NA | {
"id": "C0037114",
"name": "silicone",
"pos": [
51,
59
]
} | {
"id": "C0599034",
"name": "silicone jell",
"pos": [
98,
111
]
} |
the effect of methionine on the uptake , distribution , and binding of the convulsant methionine sulfoximine in the rat . | NA | {
"id": "C0025646",
"name": "methionine",
"pos": [
14,
24
]
} | {
"id": "C0025649",
"name": "methionine sulfoximine",
"pos": [
86,
108
]
} |
the effect of methionine on the uptake , distribution , and binding of the convulsant methionine sulfoximine ( mso ) in 7 rat brain regions , the spinal cord , the liver , and the kidney was investigated . | NA | {
"id": "C0025646",
"name": "methionine",
"pos": [
14,
24
]
} | {
"id": "C0025649",
"name": "methionine sulfoximine",
"pos": [
86,
108
]
} |
smaller changes occurred with basic and neutral amino acid transport systems , and the largest changes occurred in fetal brain with amino acids of putative neurotransmitter function ( taurine , glycine , gaba , and the acidic amino acids ) . | NA | {
"id": "C0002520",
"name": "amino",
"pos": [
48,
53
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
194,
201
]
} |
smaller changes occurred with basic and neutral amino acid transport systems , and the largest changes occurred in fetal brain with amino acids of putative neurotransmitter function ( taurine , glycine , gaba , and the acidic amino acids ) . | NA | {
"id": "C0002520",
"name": "amino",
"pos": [
48,
53
]
} | {
"id": "C0815040",
"name": "acidic amino acids",
"pos": [
219,
237
]
} |
( 3 ) exogenous putrescine and the polyamines were less firmly attached to synaptosomes and to synaptosomal membrane fractions than the endogenous amines . | NA | {
"id": "C0032433",
"name": "polyamines",
"pos": [
35,
45
]
} | {
"id": "C0002508",
"name": "amines",
"pos": [
147,
153
]
} |
( 5 ) polyamines bound to myelin constituents or mitochondria could be displaced by a 200-fold concentration of nonradioactive amines ; | NA | {
"id": "C0032433",
"name": "polyamines",
"pos": [
6,
16
]
} | {
"id": "C0002508",
"name": "amines",
"pos": [
127,
133
]
} |
sugar analyses of the flower parts indicated that growth of the ovary was accompanied by an increase in the ratio of sucrose to reducing sugars in the petals and ovary , and a net increase in sugars in the ovary . | NA | {
"id": "C0038636",
"name": "sucrose",
"pos": [
117,
124
]
} | {
"id": "C0242209",
"name": "sugars",
"pos": [
192,
198
]
} |
this suggests that the designation of pulse-labelled polydisperse rna as messenger rna or precursor to messenger rna solely on the basis of rapid labelling and size heterogeneity is unsound . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
66,
69
]
} | {
"id": "C0035696",
"name": "messenger rna",
"pos": [
103,
116
]
} |
hydrolysis and resynthesis of sucrose and related sugars in the developing stem tissues of eucalyptus regnans trees . | NA | {
"id": "C0038636",
"name": "sucrose",
"pos": [
30,
37
]
} | {
"id": "C0242209",
"name": "sugars",
"pos": [
50,
56
]
} |
muell . and incubated in vitro with [ ( 14 ) c ] glucose , [ ( 14 ) c ] galactose and [ ( 14 ) c ] fructose in the presence of sufficient pvp ( polyvinylpyrrolidone ) radioactive sucrose , members of the raffinose family and related sugars are synthesized . | NA | {
"id": "C0038636",
"name": "sucrose",
"pos": [
179,
186
]
} | {
"id": "C0242209",
"name": "sugars",
"pos": [
233,
239
]
} |
these results suggest that pvp inactivates substances which , in in vitro experiments , inhibit the action of enzymes which are essential to the resynthesis of nutrient sugars ( sucrose , raffinose and stachyose ) . | NA | {
"id": "C0242209",
"name": "sugars",
"pos": [
169,
175
]
} | {
"id": "C0038636",
"name": "sucrose",
"pos": [
178,
185
]
} |
in the presence of either phosphon d or beta-chlorethyltrimethylammonium chloride ( ccc ) at 20 degrees c there was inhibition of both ga accumulation and germination , a finding consistent with the hypothesis that ga biosynthesis is a necessary prerequisite for the germination of chilled hazel seeds . | NA | {
"id": "C0037088",
"name": "finding",
"pos": [
171,
178
]
} | {
"id": "C0085593",
"name": "chilled",
"pos": [
282,
289
]
} |
the water permeability of astomatous cuticular membranes isolated from citrus aurantium l. leaves , pear ( pyrus communis l. ) leaves and onion ( allium cepa l. ) bulb scales was determined before and after extraction of cuticular waxes with lipid solvents . | NA | {
"id": "C0043076",
"name": "waxes",
"pos": [
231,
236
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
242,
247
]
} |
after 24 h , non-viable axis tissue incorporates [ ( 3 ) h ] uridine into ribosomal rna , the low molecular weight material migrating in advance of the 4s and 5s rna peak in polyacrylamide gels and a heterogeneous rna species of molecular weight ranging from 2.2*10 ( 6 ) to 2.7*10 ( 6 ) . | NA | {
"id": "C0035701",
"name": "ribosomal rna",
"pos": [
74,
87
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
214,
217
]
} |
axis tissue of viable pea seed synthesises rrna , 4s and 5s rna , the low molecular weight material migrating in advance of the 4s and 5s rna peak in polyacrylamide gels and the rrna precursor species at both periods of germination studied . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
43,
47
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
179,
182
]
} |
chromatographic separations and fluorimetric analyses of the chlorophyll pigments showed that the reaction centre molecule could not be protochlorophyllide or chlorophyllide . | NA | {
"id": "C0008260",
"name": "chlorophyll",
"pos": [
61,
72
]
} | {
"id": "C0033715",
"name": "protochlorophyllide",
"pos": [
136,
155
]
} |
the ratio of deuterium to hydrogen ( expressed as deltad ) in hydrogen released as water during the combustion of dried plant material was examined . | NA | {
"id": "C0011744",
"name": "deuterium",
"pos": [
13,
22
]
} | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
62,
70
]
} |
in c3 and c4 plants the hydrogen isotope discrimination is in the same direction as the carbon isotope discrimination and factors contributing to the difference in deltad values are discussed . | NA | {
"id": "C0022262",
"name": "isotope",
"pos": [
33,
40
]
} | {
"id": "C0007017",
"name": "carbon isotope",
"pos": [
88,
102
]
} |
while the cell wall of the codiolum stage is mainly built up of mannans , glucose-containing polysaccharides predominate in the cell wall of the dwarf plants and xylose-containing polysaccharides are abundant in the cell wall of the filamentous plants . | NA | {
"id": "C0024727",
"name": "mannans",
"pos": [
64,
71
]
} | {
"id": "C0032594",
"name": "polysaccharides",
"pos": [
180,
195
]
} |
after a four-day period of labelling with deuterium oxide and purification of the mitochondrial isoenzyme , a density shift of 0.021kgx1 ( -1 ) , accompanied by considerable band broadening of the enzyme profile was observed . | NA | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
96,
105
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
197,
203
]
} |
the electron microscope shows that the lamellae are involved in wax formation and it is suggested that the polar lipids provide in situ precursors for the synthesis of cuticular wax . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
113,
119
]
} | {
"id": "C0043076",
"name": "wax",
"pos": [
178,
181
]
} |
at 22 degrees the content of total carotenoids was 5fold and that of beta-carotene 25fold increased by light . | NA | {
"id": "C0007271",
"name": "carotenoids",
"pos": [
35,
46
]
} | {
"id": "C0053396",
"name": "beta-carotene",
"pos": [
69,
82
]
} |
only 41 % of the total carotenoids and 18 % of the beta-carotene formed at 22 degrees in light were found at 32 degrees . of the carotenoids present at 32 degrees , 76 % were located in the light green tips of the leaves . | NA | {
"id": "C0053396",
"name": "beta-carotene",
"pos": [
51,
64
]
} | {
"id": "C0007271",
"name": "carotenoids",
"pos": [
129,
140
]
} |
the main polysaccharide of the cell wall of the sporophyte ( derbesia ) is a mannan , whereas the cell wall of the gametophyte is built up mainly of glucose- and xylose-containing polysaccharides . | NA | {
"id": "C0024727",
"name": "mannan",
"pos": [
77,
83
]
} | {
"id": "C0032594",
"name": "polysaccharides",
"pos": [
180,
195
]
} |
it was shown by histofluorometric dna determinations that a reduced synthesis of dna in continuous light is accompanied by a lower level of endomitosis in the cortex cells of the hypocotyl . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
34,
37
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
123,
124
]
} |
the biosynthetic rate of 16 identifiable proteins , most of which are components of the transcription and translation apparatus , was measured by pulse-labelling with [ 35s ] -methionine , followed by protein separation using two-dimensional gel electrophoresis ( o'farrell , 1975 ) . | NA | {
"id": "C0034861",
"name": "biosynthetic",
"pos": [
4,
16
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
201,
208
]
} |
the effects of a partial restriction of valyl-trna aminoacylation on the synthesis of aminoacyl-trna synthetases , ribosomal proteins , and other translation and transcription proteins were examined in otherwise isogenic stringent ( rela+ ) and relaxed ( rela1 ) derivatives of e. coli b . | NA | {
"id": "C0035552",
"name": "ribosomal proteins",
"pos": [
115,
133
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
176,
184
]
} |
in the isolated hybrid complex the rna : dna ratio is close to 1:1 , and the degree of enrichment of the dna by the rrna cistrons is about 1500 times . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
35,
38
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
116,
120
]
} |
in an investigation of the antigenic fine structure of phages t4 and ddvi with the use of the neutralization reaction and electron-microscopic observation of the phage-antibody complexes , it has been possible to establish that the head of phage t4 consists of proteins which have antigenic determinants of two types : the first type is identical to the antigens of the head of phage ddvi , and the second type is apparently absent in phage ddvi . | NA | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
281,
303
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
354,
362
]
} |
the treatment of denatured t4 phage dna with antiserum for the dna of this phage , containing antibodies against glucosylated 5-hydroxymethylcytosine , decreases the ability of dna for renaturation . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
45,
54
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
94,
104
]
} |
the greatest inhibiting activity is possessed by antiserum for t4 phage dna irradiated with uv light , which contains antibodies not only against glucosylated 5-hydroxymethylcytosine , but also against the usual nitrogen bases . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
49,
58
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
118,
128
]
} |
antiserum against e. coli dna , containing antibodies to the usual nitrogen bases , in equal dilutions with the antisera indicated above , shows less inhibitory activity on the renaturation of t4 phage dna . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
43,
53
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
112,
120
]
} |
it is proposed that in the infant rat the greater gh than prl responsiveness to trh , which opposed the pattern of response present in the adult animal , may be due to the existence of a 'physiologic ' functional disconnection between the central nervous system ( cns ) and the anterior pituitary ( ap ) . | NA | {
"id": "C0037663",
"name": "gh",
"pos": [
50,
52
]
} | {
"id": "C0032016",
"name": "anterior pituitary",
"pos": [
278,
296
]
} |
the basic fraction of the acid-labile amino acid precursors found in hot water extracts of the murchison meteorite was treated with ninhydrin under conditions that give destruction of free amino acids but allow nearly complete recovery to peptides and amino acylamides . | NA | {
"id": "C0301714",
"name": "basic",
"pos": [
4,
9
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
189,
200
]
} |
this idea would impose base sequence restriction on the early messages and on the early genetic code such that the first four amino acids coded were glycine , serine , aspartic acid and aspargine . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
126,
137
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
149,
156
]
} |
[ effect of dihydrotestosterone on the content of lipids in the blood serum and on their distribution among the lipoprotein fractions in rabbits with experimental hyperlipemia ] . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
50,
56
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
112,
123
]
} |
a study was made of the enzymes of the islands of langerhans which could participate in the transformation of proinsulin into insulin . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
110,
120
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
126,
133
]
} |
the second enzyme of the islands differing from the exocrine carboxypeptidase could apparently participate in the insulin formation from the intermediate forms of proinsulin . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
114,
121
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
163,
173
]
} |
[ problems in the use of plastic containers for liquid pharmaceuticals . 22. the oxygen permeability of pharmaceutically used polyethylenes studied by gas potentiometric methods ] . | NA | {
"id": "C0032167",
"name": "plastic",
"pos": [
25,
32
]
} | {
"id": "C0032487",
"name": "polyethylenes",
"pos": [
126,
139
]
} |
the values of the total ca both in the csf and in blood did not show significant statistic variations as compared to normal subjects , and yet , both in the csf and in blood a modification of the values of the ca fractions - adrenaline ( a ) and noradrenaline ( na ) - was noticed , even more visible in the csf , i.e . a decrease of the absolute values of na and an increase of the absolute values of a , determining an important increase of the adrenaline percentage ( a % ) values from the total ca which , from 23 % ( in normal subjects ) reached 52 % in the blood and 63 % in the csf in the case of asthenic neurosis . | NA | {
"id": "C0028351",
"name": "na",
"pos": [
229,
231
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
447,
457
]
} |
incidence and significance of precipitating antibodies in occupational and non-occupational extrinsic non-atopic ( type iii ) asthma ( bronchial asthma with precipitins ) . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
44,
54
]
} | {
"id": "C0032936",
"name": "precipitins",
"pos": [
157,
168
]
} |
sodium supply was proved to influence significantly the pressor response to angiotensin ii and not that to noradrenaline thus implying the presence of arterial receptors which bind angiotensin specifically . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
76,
90
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
181,
192
]
} |
in most hypertensive patients angiotensin was found to decrease the plasma angiotensinogen and to activate the bradykinin-bradykininogen and fibrinolytic systems . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
30,
41
]
} | {
"id": "C0003017",
"name": "angiotensinogen",
"pos": [
75,
90
]
} |
they were in four cases suprarenal pheochromocytomas and in the fifth case an ectopic paraganglioma of zuckerland 's organ . | NA | {
"id": "C0031511",
"name": "pheochromocytomas",
"pos": [
35,
52
]
} | {
"id": "C0030421",
"name": "paraganglioma",
"pos": [
86,
99
]
} |
the carboxylic groups are established to be necessary for manifestation of the activities of c1- and c2-cellulases , cx-exo- and cx-endoglucanases . | NA | {
"id": "C1260229",
"name": "cellulases",
"pos": [
104,
114
]
} | {
"id": "C0007641",
"name": "endoglucanases",
"pos": [
132,
146
]
} |
it is found ( under the effect of glutaric aldehyde ) that amino groups are significant for manifestation of the activities of c1- and c2-cellulases and cx-endoglucanase and to a less extent for that of cs-exoglucanase and beta-glucosidase . | NA | {
"id": "C1260229",
"name": "cellulases",
"pos": [
138,
148
]
} | {
"id": "C0007641",
"name": "endoglucanase",
"pos": [
156,
169
]
} |
it is found ( under the effect of glutaric aldehyde ) that amino groups are significant for manifestation of the activities of c1- and c2-cellulases and cx-endoglucanase and to a less extent for that of cs-exoglucanase and beta-glucosidase . | NA | {
"id": "C1260229",
"name": "cellulases",
"pos": [
138,
148
]
} | {
"id": "C0005223",
"name": "beta-glucosidase",
"pos": [
223,
239
]
} |
it is supposed that electrostatic interactions of the carbolytic and amine groups might be an essential factor for stability of c1- and c2-cellulases and cx-endoglucanase . | NA | {
"id": "C1260229",
"name": "cellulases",
"pos": [
139,
149
]
} | {
"id": "C0007641",
"name": "endoglucanase",
"pos": [
157,
170
]
} |
zones of somatotropin , prolactin and subunits of adenohypophysis glycoproteid hormones are identified in dodecyl sulphate-polyacrylamide gel after electrophoretic separation of these hormones in the tris-acetate system ; | NA | {
"id": "C0037663",
"name": "somatotropin",
"pos": [
9,
21
]
} | {
"id": "C0032016",
"name": "adenohypophysis",
"pos": [
50,
65
]
} |
in heat-treated butter , besides the altered acid value also the percentual fatty acid content was changed so that the highest decrease was found with linoleic , linolenic and higher unsaturated fatty acids , whereas the percentual content of palmitic acid increased . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
76,
86
]
} | {
"id": "C0015690",
"name": "unsaturated fatty acids",
"pos": [
183,
206
]
} |
the results indicate that the probable cause may be the appearance of polymers of unsaturated fatty acids , with higher retention times than the monomolecular fatty acids . | NA | {
"id": "C0015690",
"name": "unsaturated fatty acids",
"pos": [
82,
105
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
159,
170
]
} |
the results indicated significant losses of the nutritionally important essential fatty acids causing decreased biological butter values at heating , as well as the possibility of employing the method of saturated and unsaturated fatty acid determination for testing the losses at butter melting , even due to other reasons , as e. g. infections . | NA | {
"id": "C0015686",
"name": "essential fatty acids",
"pos": [
72,
93
]
} | {
"id": "C0015690",
"name": "unsaturated",
"pos": [
218,
229
]
} |
on the other hand , upon introduction of an amino acids mixture imitating the swedish preparation vamin , which includes all essential and non-essential amino acids ( except for glutamine and asparagine ) in proportion as found in the egg white the urea increment values turned out to be inferior than on administration of a mixture containing from among essential amino acids only arginine and histidine , and from among non-essential ones-glycine and glutamic acid . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
44,
55
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
441,
448
]
} |
on the other hand , upon introduction of an amino acids mixture imitating the swedish preparation vamin , which includes all essential and non-essential amino acids ( except for glutamine and asparagine ) in proportion as found in the egg white the urea increment values turned out to be inferior than on administration of a mixture containing from among essential amino acids only arginine and histidine , and from among non-essential ones-glycine and glutamic acid . | NA | {
"id": "C0017797",
"name": "glutamine",
"pos": [
178,
187
]
} | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
453,
466
]
} |
[ dynamics of metalloproteins and blood protein fractions in the course of treatment of patients with acute pneumonias ] . | NA | {
"id": "C0025544",
"name": "metalloproteins",
"pos": [
14,
29
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
40,
47
]
} |
pivampicillin , a new derivative of ampicillin , which has been found to give higher blood levels than corresponding doses of oral ampicillin has been tried in the treatment of 40 consecutive cases of uncomplicated gonorrhoea . | NA | {
"id": "C0032032",
"name": "pivampicillin",
"pos": [
0,
13
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
131,
141
]
} |
the slow growth rate of adenocarcinoma and alveolar cell carcinoma -- mainly in woman -- and the possibility of a scar tissue carcinoma has to be considered . | NA | {
"id": "C0001418",
"name": "adenocarcinoma",
"pos": [
24,
38
]
} | {
"id": "C0007120",
"name": "alveolar cell carcinoma",
"pos": [
43,
66
]
} |
[ iron storage and metabolism in nacrophages and endothelial cells after intravenous administration of colloidal ferric saccharate in man ] . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
2,
6
]
} | {
"id": "C0060241",
"name": "ferric saccharate",
"pos": [
113,
130
]
} |
addition of poly ( u ) to complexes of 40s and 60s subunits of rat liver ribosomes decreases the substitution of amino groups of 12 proteins of the small ribosomal subunit and of 11 proteins of the large subunit by [ 14c ] -methyl acetimidate . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
132,
140
]
} | {
"id": "C0599220",
"name": "proteins",
"pos": [
182,
190
]
} |
it has been observed that labelled gastrin or pentagastrin activity reaches its peak in the plasma in the 5th minute after intravenous injection . | NA | {
"id": "C0017151",
"name": "gastrin",
"pos": [
35,
42
]
} | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
46,
58
]
} |
next , activity in the plasma decreased after the injection of labelled gastrin , but remained unchanged after the injection of labelled pentagastrin . | NA | {
"id": "C0017151",
"name": "gastrin",
"pos": [
72,
79
]
} | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
137,
149
]
} |
the genetic markers studied were deuteranopia and protanopia ( two x-linked recessive markers ) and the xg blood group ( x-linked dominant marker ) . | NA | {
"id": "C0017393",
"name": "genetic markers",
"pos": [
4,
19
]
} | {
"id": "C0005516",
"name": "marker",
"pos": [
139,
145
]
} |
in naive rats , the xanthines , theophylline and 3-isobutyl-1-methylxanthine , produce a quasimorphine-abstinence syndrome that is readily suppressed by heroin and intensified by nalosone . | NA | {
"id": "C0043318",
"name": "xanthines",
"pos": [
20,
29
]
} | {
"id": "C0039771",
"name": "theophylline",
"pos": [
32,
44
]
} |
in naive rats , the xanthines , theophylline and 3-isobutyl-1-methylxanthine , produce a quasimorphine-abstinence syndrome that is readily suppressed by heroin and intensified by nalosone . | NA | {
"id": "C0039771",
"name": "theophylline",
"pos": [
32,
44
]
} | {
"id": "C0000096",
"name": "3-isobutyl-1-methylxanthine",
"pos": [
49,
76
]
} |
it was found that 229 out of 230 strains of pseudotuberculosis microbes tested were sensitive to aminoglycosides , such as streptomycin , monomycin , neomycin , kanamycin and gentamicin . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
97,
112
]
} | {
"id": "C0038425",
"name": "streptomycin",
"pos": [
123,
135
]
} |
it was found that 229 out of 230 strains of pseudotuberculosis microbes tested were sensitive to aminoglycosides , such as streptomycin , monomycin , neomycin , kanamycin and gentamicin . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
97,
112
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
175,
185
]
} |
the above aminoglycosides ( streptomycin , monomycin , kanamycin and gentamicin ) were active in the treatment of albino mice with experimental pseudotuberculosis . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
10,
25
]
} | {
"id": "C0038425",
"name": "streptomycin",
"pos": [
28,
40
]
} |
the above aminoglycosides ( streptomycin , monomycin , kanamycin and gentamicin ) were active in the treatment of albino mice with experimental pseudotuberculosis . | NA | {
"id": "C0002556",
"name": "aminoglycosides",
"pos": [
10,
25
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
69,
79
]
} |
along with the development of the ahterosclerofic process in the aorta , in the myocardium there were noted changes in the endothelium of capillaries , a more intensive production of acid polysaccharides by fibroblasts , a progressing development of the collagenous stroma , a higher heterogeneity of the contractile myocardium , and grave impairment of the structure and functions of the mypcardial cells ( appearance of atrophying muscular cells with a decrease in the number of myofibrils ) long before the onset of morphological changes in the coronary arteries . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
207,
218
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
442,
447
]
} |
no activity was found in the host tissue , in association with the attachment site , for either alkaline or acid phosphatase , acetylcholinesterase or cholinesterase , peroxidase or amine oxidase ( flavin-containing ) , despite the intense histochemical reaction for the latter in the tissues of larvae . | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
127,
147
]
} | {
"id": "C0008429",
"name": "cholinesterase",
"pos": [
151,
165
]
} |
autopsy pancreas samples devoid of tame ( p-tosyl arginine methyl ester ) esterase activity ( e.g . trypsin and plasma enzymes such as thrombin and plasmin ) had isoenzyme patterns different to those samples with free proteolytic activity . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
119,
126
]
} | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
162,
171
]
} |
significant bacteriuria was considered as an important criterion in the diagnosis of urinary tract infection . | NA | {
"id": "C0004659",
"name": "bacteriuria",
"pos": [
12,
23
]
} | {
"id": "C0042029",
"name": "of urinary tract infection",
"pos": [
82,
108
]
} |
an electrophoretically homogeneous trypsin-like proteinase , two homogeneous proteases ( presumably metal-containing ) and two elastases , possessing the atee-esterase activity , were isolated from protofradin , a protease preparation from actinomyces fradiae 119 , using fractionation on km-cellulose k-32 . | NA | {
"id": "C0030940",
"name": "proteases",
"pos": [
77,
86
]
} | {
"id": "C0030946",
"name": "protease preparation",
"pos": [
214,
234
]
} |
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