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stringlengths 57
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stringclasses 125
values | h
dict | t
dict |
|---|---|---|---|
using electrophoresis in agarose-polyacrylamide gel the radioactive proteins synthesized in the cell culture of normal rabbit spleen it was shown that in normal spleen the average amount of globulins makes up to 35 % of total protein synthesis , as reported by some authors . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
68,
76
]
} | {
"id": "C0017649",
"name": "globulins",
"pos": [
190,
199
]
} |
it is assumed that the differences found are determined by the composition of lipid components of the membranes studied and that the amount of proteins closely bound with lipids in the membranes of s. faecalis is likely to be greater than that of m. lysodeikticus membranes . | NA | {
"id": "C0025249",
"name": "lipid",
"pos": [
78,
83
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
171,
177
]
} |
pretreatment of peroxidase by its covalent coupling to inert proteins and albumin by means of glutaraldehyde considerably increases the thermostability and specific activity of polyacrylamide gel ( paag ) immobilized peroxidase . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
61,
69
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
74,
81
]
} |
the effects of paag composition on the catalytic properties of the immobilized oligomers : peroxidase-inert proteins-albumin , are studied . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
108,
116
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
117,
124
]
} |
it is shown that the increase in the adp/atp ratio does not change the na+ , k+-atpase affinity to k+ ions and does not result in the na-activated , k-independent atpase reaction . | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
80,
86
]
} | {
"id": "C0001479",
"name": "na",
"pos": [
134,
136
]
} |
[ comparative study of nuclear rna of the liver and experimental hepatoma by the method of dna-rna molecular hybridization ] . | NA | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
23,
34
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
95,
98
]
} |
the results obtained support the assumption that a high sensitivity of the inducible isoenzymes to proteases provides for a removal of excessive amounts of the enzymes from the cells under cessation of hormonal induction , thus maintaining enzymatic homostasis in the cell . | NA | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
85,
95
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
160,
167
]
} |
sinergistic inhibition was observed under the combined effect of amino acids on gs in the presence of mn and aspartate or alanine . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
65,
76
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
122,
129
]
} |
the change of gs activity observed is supposed to be due to the inhibitory effect of glutamine and amino acids studied , since the glutamine content is increased ( in 2.5 times for 5 min ) and that of alanine and dicarbonic amino acids ( for the following 15 min ) under nh assimilation in chlorella cells . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
201,
208
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
224,
235
]
} |
a possibility of structural organization of glycolytic enzymes in the cell essential for the quantitative estimation of the isozyme pattern is discussed . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
55,
62
]
} | {
"id": "C0022173",
"name": "isozyme",
"pos": [
124,
131
]
} |
many abnormal movements have been reported in huntington 's disease , but myoclonus is a relatively uncommon feature of this disorder and to our knowledge intention myoclonus has not been reported as a major symptom . | NA | {
"id": "C0013384",
"name": "abnormal movements",
"pos": [
5,
23
]
} | {
"id": "C0027066",
"name": "myoclonus",
"pos": [
165,
174
]
} |
the precipitated immune-complexes are treated with antibodies conjugated with an enzyme specific for each class of immuno-globulins . | NA | {
"id": "C0003313",
"name": "immune-complexes",
"pos": [
17,
33
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
51,
61
]
} |
the absorption , metabolism and excretion of sulphasalazine is similar in volunteers and patients with ulcerative colitis or crohn 's disease . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
17,
27
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
32,
41
]
} |
sar -ala -angiotensin ii ( saralasin , 400 pmol min-1 kg-1 ) suppressed plasma aldosterone that was stimulated by heptapeptide ( 20 pmol min-1 kg-1 ) completely . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
10,
24
]
} | {
"id": "C0036193",
"name": "saralasin",
"pos": [
27,
36
]
} |
the same angiotensin antagonist had only a moderate effect on plasma aldosterone stimulated by aii . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
9,
20
]
} | {
"id": "C0003009",
"name": "aii",
"pos": [
95,
98
]
} |
des-angiotensin substrate was prepared from the purified angiotensinogen preparation by reaction with immobilized hog renin ( coupled to sepharose ) . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
4,
15
]
} | {
"id": "C0003017",
"name": "angiotensinogen",
"pos": [
57,
72
]
} |
renin can induce vascular disease , but hypersecretion of renin is not a necessary condition for the development of hypertensive arteriolar necrosis . | NA | {
"id": "C0042373",
"name": "vascular disease",
"pos": [
17,
33
]
} | {
"id": "C0020538",
"name": "condition",
"pos": [
83,
92
]
} |
saralasin ( sar1-ala8-angiotensin ii ) , a competitive inhibitor of angiotensin ii ( aii ) , has been infused into normal subjects and patients with essential hypertension when deprived of sodium by 5 days of a 10 mmol/day sodium diet . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
0,
9
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
68,
82
]
} |
( b ) normal-renin hypertensive patients when sodium deprived by diet alone do not appear to be angiotensin ii dependent ( angiotensin ii is unlikely therefore to be directly maintaining their blood pressure on their normal sodium intake ) ; ( c ) the rise in blood pressure seen in low-renin hypertensive patients with saralasin may be a further way of distinguishing this group of patients . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
96,
110
]
} | {
"id": "C0036193",
"name": "saralasin",
"pos": [
320,
329
]
} |
these results implicate peripheral noradrenaline-containing neurons and central adrenaline-containing neurons in the development of genetic and experimental hypertension in rats . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
35,
48
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
80,
90
]
} |
noradrenaline , adrenaline and alpha-methylnoradrenaline administration into the nucleus tractus solitarii ( nts ) of anaesthetized rats decreased blood pressure and heart rate in a dose-dependent fashion . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
0,
13
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
46,
56
]
} |
noradrenaline , adrenaline and alpha-methylnoradrenaline administration into the nucleus tractus solitarii ( nts ) of anaesthetized rats decreased blood pressure and heart rate in a dose-dependent fashion . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
0,
13
]
} | {
"id": "C0025805",
"name": "alpha-methylnoradrenaline",
"pos": [
31,
56
]
} |
in spontaneously hypertensive rats increased concentrations of noradrenaline , adrenaline and dopamine were measured in the part of the nts located just caudal to the obex ( a2 region ) . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
63,
76
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
79,
89
]
} |
injections of antagonists of angiotensin ii into the cerebral ventricles of normotensive and spontaneously hypertensive rats were performed in order to assess the role of the isorenin-angiotensin system in the brain . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
29,
43
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
184,
195
]
} |
the conversion of [ 3h ] tyrosine ( given intraperitoneally ) to dopa ( 3,4-dihydroxypheylalanine ) and catecholamines was measured in the hearts and adrenals of control rats and animals pretreated with carbidopa ( 100 mg/kg , intraperitoneally ) . | NA | {
"id": "C0013023",
"name": "dopa",
"pos": [
65,
69
]
} | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
104,
118
]
} |
when the injections were made into the bathing blood close to the everted rat aorta , angiotensin ii was half as potent as adrenaline or noradrenaline on a molar basis . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
123,
133
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
137,
150
]
} |
after intravenous injections , the vasoconstrictor potency of angiotensin was twenty times that of adrenaline or noradrenaline on the everted rat aorta . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
99,
109
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
113,
126
]
} |
methyldopa ( 250 mg ) is equivalent to 6-0 mg of debrisoquine and 0-5 mg of st 600 ( boehringer ) , which is a clonidine-like substituted imidazoline . | NA | {
"id": "C0009014",
"name": "clonidine",
"pos": [
111,
120
]
} | {
"id": "C1449836",
"name": "imidazoline",
"pos": [
138,
149
]
} |
an analysis of the data shows that the normal chance of breakthrough bleeding on a particular day when one oral contraceptive tablet is not missed on the previous day is 0.017 , 0.022 , and 0.022 for ovral , norinyl , norlestrin users , but the chance on the day after a contraceptive tablet is missed increased by 13 to 16 times for each of the three ocs . | NA | {
"id": "C0993159",
"name": "oral",
"pos": [
107,
111
]
} | {
"id": "C0039225",
"name": "tablet",
"pos": [
285,
291
]
} |
this method provides a means whereby cells growing from explanted tumor tissue can be immediately cloned and the fibroblastic ( nonneoplastic ) cells thus selected against . | NA | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
113,
125
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
144,
149
]
} |
also introduced is a modification of the anti-complement immunofluorescence ( acif ) test for ebv-determined nuclear antigen ( ebna ) , permitting simultaneous titration of antibodies to this nuclear antigen and of the anti-nuclear factor ( anf ) . | NA | {
"id": "C0116397",
"name": "ebv",
"pos": [
94,
97
]
} | {
"id": "C0069115",
"name": "nuclear antigen",
"pos": [
192,
207
]
} |
stimulation of cell proliferation by serum was followed by an 18-100-fold increase in the rate of putrescine transport , which was not inhibitable with cyclic amp , dibutyryl cyclic amp , or prostaglandin e1 . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
152,
162
]
} | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
165,
185
]
} |
both this ruffling activity and the rearrangement of label are sensitive to cytochalasin b , and ruffling activity , perhaps along with other cytochalasin-sensitive structure , may play a role in the rearrangements of labeled sites . | NA | {
"id": "C0010737",
"name": "cytochalasin",
"pos": [
76,
88
]
} | {
"id": "C0010739",
"name": "cytochalasin",
"pos": [
142,
154
]
} |
open reduction with circular wire fixation is one method by which proper approximation of comminuted fracture bone segments can be accomplished . | NA | {
"id": "C0016658",
"name": "of",
"pos": [
87,
89
]
} | {
"id": "C0476171",
"name": "comminuted",
"pos": [
90,
100
]
} |
the alpha-helix content of the flagellar components was diminished in the presence of zinc , cadmium and mercury , while no other heavy metals contributed to such a change . | NA | {
"id": "C0043481",
"name": "zinc",
"pos": [
86,
90
]
} | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
130,
142
]
} |
the alpha-helix content of the flagellar components was diminished in the presence of zinc , cadmium and mercury , while no other heavy metals contributed to such a change . | NA | {
"id": "C0006632",
"name": "cadmium",
"pos": [
93,
100
]
} | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
130,
142
]
} |
the alpha-helix content of the flagellar components was diminished in the presence of zinc , cadmium and mercury , while no other heavy metals contributed to such a change . | NA | {
"id": "C0025424",
"name": "mercury",
"pos": [
105,
112
]
} | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
130,
142
]
} |
[ the reaction of heteroaromatic n-oxide with acid chloride and cyanide . i. on the reaction of 2-substituted and 2,3-disubstituted quinoline 1-oxides with aroyl chloride and potassium cyanide ( author 's transl ) ] . | NA | {
"id": "C0010505",
"name": "cyanide",
"pos": [
64,
71
]
} | {
"id": "C0032826",
"name": "potassium cyanide",
"pos": [
175,
192
]
} |
63 of them had survived myocardial infarction , 63 had angina of effort , 65 -- angina at rest and angina of effort , 2 presented no complaints . | NA | {
"id": "C0002965",
"name": "angina at rest",
"pos": [
80,
94
]
} | {
"id": "C0002962",
"name": "angina of effort",
"pos": [
99,
115
]
} |
the changes in the absorption-excretory function of the liver and of the hepatic blood circulation are described on the basis of a dynamic observation ( on the 1st , 20 -- 30th , 50 -- 60th day of the onset of the disease ) and with due regard of the extent of the myocardial infarction and the presence of complications , cardiogenic shock in particular . | NA | {
"id": "C0027051",
"name": "myocardial infarction",
"pos": [
265,
286
]
} | {
"id": "C0036980",
"name": "cardiogenic shock",
"pos": [
323,
340
]
} |
investigations into the structure , mechanical properties and permeability of the soviet-made cellophane , cellulose film no 100 and cuprophane have shown the soviet-made cellophane membrane to be inferior to cuprophane with regard to the strength and permeability of low-molecular metabolites . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
107,
116
]
} | {
"id": "C0007633",
"name": "cellophane",
"pos": [
171,
181
]
} |
high strength properties of the cellulose film no 100 go with a much more lower permeability than in the case of cuprophane and cellophane . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
32,
41
]
} | {
"id": "C0007633",
"name": "cellophane",
"pos": [
128,
138
]
} |
recent investigations of the effect of fgf on diverse cell types has shown that fgf stimulates the division of cells from a wide variety of tissues of mesodermal origin including fibroblasts , chondrocytes , myoblasts , smooth muscle cells , glial cells , normal adrenal cells , and the y1 adrenal cell line . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
179,
190
]
} | {
"id": "C0007634",
"name": "normal",
"pos": [
256,
262
]
} |
recent investigations of the effect of fgf on diverse cell types has shown that fgf stimulates the division of cells from a wide variety of tissues of mesodermal origin including fibroblasts , chondrocytes , myoblasts , smooth muscle cells , glial cells , normal adrenal cells , and the y1 adrenal cell line . | NA | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
193,
205
]
} | {
"id": "C0007634",
"name": "normal",
"pos": [
256,
262
]
} |
the transport activity of the a system ( alanine preferring ) is inhibited by high internal of substrate amino acids , a process termed trans-inhibition . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
41,
48
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
105,
116
]
} |
culturing the fibroblasts in the absence of serum for 12 to 24 hr also increased the quantity of exposed k2 sites to 60,000 per cell . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
14,
25
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
128,
132
]
} |
have carried out in patients affected by proved myocardial infarct , by other cardiac diseases and by muscular dystrophy the following enzymes determinations : total cpk , total ldh , sgot , sgpt , hbdh , cpk isoenzymes by column chromatography ( mercer 's method ) and ldh isoenzymes either by column chromatography ( mercer 's method ) and by electrophoretic separation . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
135,
142
]
} | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
274,
284
]
} |
immediately after the last attack the victim mice were decapitated along with unattacked control mice of the appropriate strain , and plasma norepinephrine ( ne ) and epinephrine ( e ) were measured . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
141,
155
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
167,
178
]
} |
goats were infected with trypanosoma vivax or inoculated with a low pyrogenic dose of lipopolysaccharide ( lps ) obtained from escherichia coli or salmonella typhimurium in order to obtain evidence about the role of kinins and serotonin in the pathogenesis of trypanosomiasis and in endotoxin induced ruminal stasis . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
86,
104
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
283,
292
]
} |
several abnormal haemoglobins were found with the following frequencies : hb e 5.25 % , hb cosp 2.38 % , hb a2 indonesia 0.80 % , a fast moving hb with a mobility between a and bart 's 0.64 % and hb q 0.16 % . | NA | {
"id": "C0019047",
"name": "abnormal",
"pos": [
8,
16
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
196,
198
]
} |
the human serum proteins with a carbohydrate portion of more than 10 per cent in the molecule , alpha1-acid glycoprotein , alpha1-antichymotrypsin , alpha1b-glycoprotein and alpha2hs-glycoprotein were studied in thirteen cases of protein-energy malnutrition . | NA | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
108,
120
]
} | {
"id": "C0051477",
"name": "alpha2hs-glycoprotein",
"pos": [
174,
195
]
} |
efficacy of chelation therapy with intravenous calcium disodium edetate , oral ca edta , and oral penicillamine was tested in 63 subjects with chronic minimal industrial exposure to lead . | NA | {
"id": "C0006692",
"name": "calcium disodium edetate",
"pos": [
47,
71
]
} | {
"id": "C0013618",
"name": "edta",
"pos": [
82,
86
]
} |
the environment was sanated by three-fold disinfections every sixth day with lysol , formalin or veraform , anf fumigation with formaldehyde vapours , resulting in 100 per cent effectiveness . | NA | {
"id": "C0949307",
"name": "formalin",
"pos": [
85,
93
]
} | {
"id": "C0016564",
"name": "formaldehyde",
"pos": [
128,
140
]
} |
alteration in content of catecholamines , dopa and the monoaminooxidase activity ( mao ) were observed in rat myocardium under prolonged administration of cobalt ( 5 mg of the metal per 1 kg of body weight ) . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
25,
39
]
} | {
"id": "C0013023",
"name": "dopa",
"pos": [
42,
46
]
} |
[ role of intracellular proteinases and glycosidases in the degradation of the 'large glycoprotein ' responsible for the neuraminidase and hemagglutinating activity of the newcastle disease virus ] . | NA | {
"id": "C0017976",
"name": "glycosidases",
"pos": [
40,
52
]
} | {
"id": "C0027803",
"name": "neuraminidase",
"pos": [
121,
134
]
} |
these data suggested that the action of intracellular proteinases and glycosidases are the cause of degradation of 'large glycoprotein ' , responsible for neuraminidase and hemagglutinin activities in ndv-infected cells . | NA | {
"id": "C0017976",
"name": "glycosidases",
"pos": [
70,
82
]
} | {
"id": "C0027803",
"name": "neuraminidase",
"pos": [
155,
168
]
} |
content of hydroxyproline , thyrosine , hexuronic acids , hexoses and dry weight of lungs were studied in animals with pneumoconiosis , caused by various agents : two types of silicosis , induced by crystalline and condensed modifications of silica , and anthracosis , caused by anthracite . | NA | {
"id": "C0032273",
"name": "pneumoconiosis",
"pos": [
119,
133
]
} | {
"id": "C0003165",
"name": "anthracosis",
"pos": [
255,
266
]
} |
extract of normal escherichia coli ck cells methylated dna of cd phage in vitro in presence of 3h-s-adenosyl methionine , although in vivo methylation of viral dna did not occur . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
55,
58
]
} | {
"id": "C0012939",
"name": "viral",
"pos": [
154,
159
]
} |
content of adrenaline , noradrenaline , dopamine , dopa and normethanephrine was estimated by means of the hydroxyindole method in brain tissue and hypothalamic region of rats subjected to hemorrhagic shock ( loss of 3 % of blood during 20 min ) within 15 min , 2 , 24 and 72 hrs . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
11,
21
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
24,
37
]
} |
at the first day after the hemorrhage an increase in content of adrenaline and a distinct decrease in content of noradrenaline were observed in hypothalamic region , although the biosynthesis the neurotransmitters was not inhibited . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
64,
74
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
113,
126
]
} |
tests conducted on dogs established that glutaminic and aspargic acids introduced into the blood by the drip method call forth inhibition of the gastric secretion stimulated by other amino acids ( alanine , glycine , proline ) . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
183,
194
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
197,
204
]
} |
tests conducted on dogs established that glutaminic and aspargic acids introduced into the blood by the drip method call forth inhibition of the gastric secretion stimulated by other amino acids ( alanine , glycine , proline ) . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
183,
194
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
207,
214
]
} |
the method of adsorption on a monolayer of embryonal fibroblasts of 51cr-labelled spleen cells from cba and c57b1/6 mice infected at birth with sa7 ( c8 ) virus was used to show that the cells immune to the antigens of mouse embryo fibroblasts accumulated in the spleen of cba mice highly susceptible to oncogenesis induced by sa7 ( c8 ) virus . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
53,
64
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
187,
192
]
} |
in the spleen of c57b1/6 mice insusceptible to oncogenesis induced by sa7 ( c8 ) virus there was no accumulation of cell antibody to the antigens of embryonal fibroblasts ( p greater than 0.1 ) . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
116,
120
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
159,
170
]
} |
plasma 17alpha oh progesterone was assayed radioimmunologically , using an anti-17-oh-progesterone bsa antiserum as specific binding antigen . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
18,
30
]
} | {
"id": "C0020387",
"name": "17-oh-progesterone",
"pos": [
80,
98
]
} |
the cu-gapd complex is stable in solutions containing phosphate or pyrophosphate anions , but undergoes a slow change in sulfate- , and a rapid change in chloride-containing solutions . | NA | {
"id": "C0031603",
"name": "phosphate",
"pos": [
54,
63
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
81,
87
]
} |
the cu-gapd complex is stable in solutions containing phosphate or pyrophosphate anions , but undergoes a slow change in sulfate- , and a rapid change in chloride-containing solutions . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
81,
87
]
} | {
"id": "C0038720",
"name": "sulfate",
"pos": [
121,
128
]
} |
the cu-gapd complex is stable in solutions containing phosphate or pyrophosphate anions , but undergoes a slow change in sulfate- , and a rapid change in chloride-containing solutions . | NA | {
"id": "C0003075",
"name": "anions",
"pos": [
81,
87
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
154,
162
]
} |
as far as electrophoretic mobility is concerned these proteins were indistinguishable from the proteins of the nuclear poly ( a ) -containing rnp . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
54,
62
]
} | {
"id": "C0028589",
"name": "proteins",
"pos": [
95,
103
]
} |
pf stimulates initiation of growth in different types of cells : 3t3 mouse fibroblast wi-38 human fibroblasts , y-1 mouse adrenal cells and c-6 rat glial cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
98,
109
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
154,
159
]
} |
experimental ( rabbit ) penetrating keratoplasties with donor tissue sensitized to a bacterial antigen ( streptococcus group a ) were placed in normal rabbits and animals sensitized to the same antigen . | NA | {
"id": "C0003321",
"name": "bacterial antigen",
"pos": [
85,
102
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
194,
201
]
} |
sensitivity to the emergence of ihd in the trial population is increased by including as diagnostic indices angina and ischaemic ecg changes , using suitably objective methods , as well as myocardial infarction and sudden death . | NA | {
"id": "C0151744",
"name": "the",
"pos": [
15,
18
]
} | {
"id": "C0027051",
"name": "myocardial infarction",
"pos": [
189,
210
]
} |
one year mortality was related to age but not sex , previous symptoms of coronary heart disease , but not hypertension or diabetes , to tachycardia and congestive cardiac failure at first examination , but not arrhythmias in the acute episode . | NA | {
"id": "C0018799",
"name": "of",
"pos": [
70,
72
]
} | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
210,
221
]
} |
the kinetics of inhibition of the human red blood cell cholinesterase with galanthamine tacrine and oxazyl ( ambenonium ) and the effect of these drugs on chick , mouse , cat and rat blood plasma enzyme activity was studied . | NA | {
"id": "C0002413",
"name": "oxazyl",
"pos": [
100,
106
]
} | {
"id": "C0002412",
"name": "ambenonium",
"pos": [
109,
119
]
} |
the incubation of control rats hemolysate with hydrogen peroxide ( 10 ( -3 ) m ) or with kumole peroxide ( 1.6 10 ( -4 ) m ) also led to pronounced fall of the initial erythrocyte superoxide dismutase activity . | NA | {
"id": "C0020281",
"name": "hydrogen",
"pos": [
47,
55
]
} | {
"id": "C0031180",
"name": "peroxide",
"pos": [
182,
190
]
} |
preliminary immunization of c57bl donors with cba isoantigens led to a marked enhancement , and immunization with foreign antigens ( sheep red blood cells ) -- to weakening the reaction . | NA | {
"id": "C0022145",
"name": "isoantigens",
"pos": [
50,
61
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
122,
130
]
} |
the study of the fatty acids distribution shows : a ) a high level of saturated short chains fatty acids , b ) a high level of palmitic acid ( c 16:0 , 68 % of the total ) . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
17,
28
]
} | {
"id": "C0015691",
"name": "short chains fatty acids",
"pos": [
80,
104
]
} |
the labeling index ( li ) and the growth fraction vary widely among human tumors , but they are correlated with the histologic type of the tumor . | NA | {
"id": "C0027651",
"name": "tumors",
"pos": [
74,
80
]
} | {
"id": "C0027652",
"name": "histologic type of",
"pos": [
116,
134
]
} |
the depression of li after irradiation is more important in human tumors than in experimental tumors and varies widely among human tumors . | NA | {
"id": "C0027659",
"name": "experimental tumors",
"pos": [
81,
100
]
} | {
"id": "C0027651",
"name": "tumors",
"pos": [
131,
137
]
} |
acute pressor intravenous injection of angiotensin ii into nephrectomized rats immediately before removing uteri , did not affect the number of uterine angiotensin receptors , whereas long-lasting angiotensin infusion did reduce the number of receptors . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
39,
53
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
197,
208
]
} |
b ) `` '' common generalized epilepsy '' '' ( also called `` '' centrencephalic '' '' epilepsy ) , characterized by petit mal absences or a combination of petit mal and grand mal and with a predominantly favorable prognosis . | NA | {
"id": "C0014548",
"name": "generalized epileps",
"pos": [
17,
36
]
} | {
"id": "C0014553",
"name": "of petit",
"pos": [
152,
160
]
} |
b ) `` '' common generalized epilepsy '' '' ( also called `` '' centrencephalic '' '' epilepsy ) , characterized by petit mal absences or a combination of petit mal and grand mal and with a predominantly favorable prognosis . | NA | {
"id": "C0014548",
"name": "generalized epileps",
"pos": [
17,
36
]
} | {
"id": "C0014549",
"name": "and grand",
"pos": [
165,
174
]
} |
on the 5th or 6th day , severe general changes in the eeg appear along with symptoms of confusion to delirium . | NA | {
"id": "C0009676",
"name": "confusion",
"pos": [
88,
97
]
} | {
"id": "C0011206",
"name": "delirium",
"pos": [
101,
109
]
} |
a variety of food containers , drinking cups and cutlery , fabricated from polystyrene ( ps ) or polystyrene-related plastic , were analyzed for their styrene monomer content . | NA | {
"id": "C0032604",
"name": "polystyrene",
"pos": [
75,
86
]
} | {
"id": "C0032167",
"name": "plastic",
"pos": [
117,
124
]
} |
the intoxication is marked by a period of ocular and nasal irritation followed by a short remission time , then death occurs after asphyxic convulsions . | NA | {
"id": "C0011065",
"name": "death",
"pos": [
112,
117
]
} | {
"id": "C0004044",
"name": "asphyxic",
"pos": [
131,
139
]
} |
thirty children over the age of one month were treated with amikacin ( bbk8 ) , a new aminoglycoside derived from kanamycin a , with three intramuscular dosage schedules . | NA | {
"id": "C0002499",
"name": "amikacin",
"pos": [
60,
68
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
114,
123
]
} |
the activity of amikacin , gentamicin and kanamycin was tested in vitro against clinical isolates of pseudomonas aeruginosa . | NA | {
"id": "C0002499",
"name": "amikacin",
"pos": [
16,
24
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
42,
51
]
} |
concentrations of the antibiotics in serum and in saline solution were prepared according to serum levels produced in volunteers 15 minutes , 1,2 , and 6 hours after a single intramuscular injection of 500 mg amikacin , 80 mg gentamicin and 500 mg kanamycin . | NA | {
"id": "C0002499",
"name": "amikacin",
"pos": [
209,
217
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
248,
257
]
} |
cephradine was compared to cephalexin a randomized , double-blind study for the treatment of bacterial infections in 162 children between four months and eleven years of age . | NA | {
"id": "C0007738",
"name": "cephradine",
"pos": [
0,
10
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
27,
37
]
} |
there was particularly a big increase in the relative amounts of cysteine and mercapturic acid conjugates excreted . | NA | {
"id": "C0010654",
"name": "cysteine",
"pos": [
65,
73
]
} | {
"id": "C0001047",
"name": "mercapturic acid",
"pos": [
78,
94
]
} |
cytoplasmic tyrosine transaminase ( l-tyrosine : 2-oxoglutarate aminotransferase , ec 2.6.1.5 ) was partially purified from normal , host liver and three morris hepatomas and subsequently resolved by electrophoresis on polyacrylamide gels . | NA | {
"id": "C0041487",
"name": "tyrosine transaminase",
"pos": [
12,
33
]
} | {
"id": "C0002594",
"name": "aminotransferase",
"pos": [
64,
80
]
} |
under the ratio of interacting cell elements 1 : 1-1 : 2 , 93-96 % of precursor cells and 98 % of antibody forming cells were inactivated . | NA | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
70,
85
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
115,
120
]
} |
during the primary response , under the ratio 1 : 1 , only 20-48 % of precursor cells and 68 % of antibody forming cells were inactivated . | NA | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
70,
85
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
115,
120
]
} |
in order to obtain amino acid mixtures devoid of phenylalanine , adsorption of aromatic amino acids was studied during their chromatography on ion-exchange resin ia-ip . | NA | {
"id": "C0031453",
"name": "phenylalanine",
"pos": [
49,
62
]
} | {
"id": "C0301713",
"name": "aromatic amino acids",
"pos": [
79,
99
]
} |
influence of tetrahydropapaveroline on adipose tissue metabolism in comparison with that of noradrenaline , theophylline and papaverine . | NA | {
"id": "C0039674",
"name": "tetrahydropapaveroline",
"pos": [
13,
35
]
} | {
"id": "C0030350",
"name": "papaverine",
"pos": [
125,
135
]
} |
[ mortality rate by infectious and parasitic diseases in the city of veracruz in 1970 and in 1975 ] . | NA | {
"id": "C0009450",
"name": "infectious",
"pos": [
20,
30
]
} | {
"id": "C0030499",
"name": "parasitic diseases",
"pos": [
35,
53
]
} |
cocultivation of the mouse erythroleukemia cells with excess human fibroblasts did not prevent erythroid differentiation of the erythroleukemia cells in the presence of dimethylsulfoxide . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
43,
48
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
67,
78
]
} |
thus , extinction of blobin gene expression in the human fibroblast x erythroleukemia hybrids occurred at the level of mrna production and appeared to be due to the presence of the fibroblast genome within the hybrial cell . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
57,
67
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
218,
222
]
} |
the standard `` '' budr-visible-light '' '' procedure is then used to select those cells which can use adenine but can not use hypoxanthine as a purine source . | NA | {
"id": "C0001407",
"name": "adeni",
"pos": [
103,
108
]
} | {
"id": "C0034140",
"name": "a puri",
"pos": [
143,
149
]
} |
these cells are shown to be thioguanine resistant , to be unable to incorporate exogenously added hypoxanthine into purine nucleotides , to complement our other adenine-specific purine auxotrophs , ade-h and ade-i but not to complement a cell isolated by virtue of thioguanine resistance , and to lack the activity of hgprt . | NA | {
"id": "C0001407",
"name": "adenine",
"pos": [
161,
168
]
} | {
"id": "C0034140",
"name": "purine",
"pos": [
178,
184
]
} |
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