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these results indicate that stimulation of human t cells via the cd2 ag with the t11 ( 2 ) and t11 ( 3 ) mab activates not only protein kinase c but also tyrosine kinase ( s ) , resulting in the phosphorylation of the cd3 gamma-chain and the tyrosine phosphorylation of the zeta-chain , respectively . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
49,
56
]
} | {
"id": "C0108773",
"name": "cd2",
"pos": [
65,
68
]
} |
one interpretation of these results is that t cells may have the ability to circumvent allelic exclusion at the tcr-alpha locus early in their ontogeny . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
44,
51
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
112,
115
]
} |
the close resemblance between t cell responses to se and those to mixed-lymphocyte stimulating ( mls ) locus suggests to us that a novel se-like protein that binds both to class ii mhc molecules on the apc surface and to v beta gene products on tcr could be the product of the mls locus . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cell",
"pos": [
30,
36
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
245,
248
]
} |
because sc have been recognized recently to have an immunogenic potential inducible to present protein autoantigens to autoimmune t lymphocytes , and considering their close proximity to the acetylcholine receptor ( achr ) -bearing postsynaptic membranes , presentation of soluble and membrane vesicle-bound achr to appropriate t cells was investigated . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t lymphocytes",
"pos": [
130,
143
]
} | {
"id": "C0034790",
"name": "achr",
"pos": [
308,
312
]
} |
epithelial cells lining central airways ( trachea , bronchi , and bronchioli ) and respiratory glands were specifically stained by antibodies recognizing ca125 , ca19-9 , and cea . | tissue_is_expression_site_of_gene_product | {
"id": "C0014597",
"name": "epithelial cells",
"pos": [
0,
16
]
} | {
"id": "C0007082",
"name": "cea",
"pos": [
175,
178
]
} |
the islet b cells identified with anti-insulin immunoreactivity , which displayed a very weak formaldehyde-induced fluorescence , did not react with anti-serotonin serum . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet",
"pos": [
4,
9
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
39,
46
]
} |
using changes in gamma-emission from blood after previous labelling of erythrocytes with 51cr , and changes in packed cell volume , haemoglobin and erythrocyte count , a reversible shift of fluid from the intravascular phase was demonstrated in the uraemic subjects . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "blood",
"pos": [
37,
42
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
132,
143
]
} |
sera from 162 saudi arab children were examined for autoantibodies to thyroid microsomes , thyroglobulin pancreatic islet cells , gastric parietal cells , and adrenocortical cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
70,
77
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
91,
104
]
} |
a number of in vivo studies suggest that hypothalamic somatostatin ( srif ) tone is stimulated by the beta-adrenergic system . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
41,
53
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
69,
73
]
} |
employing dispersed adult male rat hypothalamic cells , we studied the effects of beta-adrenergic antagonists on the release of hypothalamic srif . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
35,
47
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
141,
145
]
} |
these findings support the hypothesis that beta-adrenergic antagonists augment gh responsivity by inhibiting hypothalamic srif release . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
109,
121
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
122,
126
]
} |
the influence of gal on gh secretion appears to be exerted within the hypothalamus , mainly by a stimulation of grf secretion . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
70,
82
]
} | {
"id": "C0023610",
"name": "grf",
"pos": [
112,
115
]
} |
since changes in lh pulse amplitudes can result from hypothalamic and/or pituitary factors , we also assessed pituitary responsiveness to exogenous gnrh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
53,
65
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
148,
152
]
} |
the purified chymotrypsinlike protease degraded the basement membrane components type iv collagen , laminin , and fibronectin . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
52,
69
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
81,
97
]
} |
the mnng-hos cells were also found to have a greater potential for invasion through reconstituted basement membrane , matrigel , the major components of which are laminin and type iv collagen . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
98,
115
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
175,
191
]
} |
characterization by affinity cross-linking of a receptor for atrial natriuretic peptide in cultured human thyroid cells associated with reductions in both adenosine 3',5'-monophosphate production and thyroglobulin secretion . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
106,
113
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
200,
213
]
} |
we have previously identified specific atriopeptin ( anp ) receptors in cultured human thyroid cells and demonstrated that anp reduced thyroglobulin ( tg ) secretion . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
87,
94
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
135,
148
]
} |
the overall pattern of cell production in the hypothalamus is known from autoradiographic studies with general nuclear stains , but no data are available on the birthdates ( times of final mitoses ) of grf-producing cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
46,
58
]
} | {
"id": "C0037668",
"name": "grf",
"pos": [
202,
205
]
} |
as has been shown for the hypothalamus in general , the grf cells showed a gradient of production from anterior to posterior . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
26,
38
]
} | {
"id": "C0037668",
"name": "grf",
"pos": [
56,
59
]
} |
using this approach it was shown that a large proportion of the cells in the sheep anterior pituitary glands examined were mammotrophs or somatotrophs , showing no significant co-localization of gh and prolactin . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "anterior pituitary glands",
"pos": [
83,
108
]
} | {
"id": "C0033371",
"name": "prolactin",
"pos": [
202,
211
]
} |
negative correlations were found between erythropoietin and the rbc , and the hb and ht in the cases with liver cirrhosis . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
64,
67
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
78,
80
]
} |
recent work in our laboratory has shown that the thymus-derived polypeptide thymopoietin potently and specifically interacts at the nicotinic alpha-bgt site in brain . | tissue_is_expression_site_of_gene_product | {
"id": "C0040113",
"name": "thymus",
"pos": [
49,
55
]
} | {
"id": "C0040105",
"name": "thymopoietin",
"pos": [
76,
88
]
} |
these results indicate that the thymic polypeptide thymopoietin specifically interacts with the nicotinic alpha-bgt receptor population and , furthermore , can regulate the toxin binding sites in chromaffin cells in culture . | tissue_is_expression_site_of_gene_product | {
"id": "C0040113",
"name": "thymic",
"pos": [
32,
38
]
} | {
"id": "C0040105",
"name": "thymopoietin",
"pos": [
51,
63
]
} |
in the red blood cell isoimmunized pregnancies there was a significant positive correlation between the aortic mean velocity and the hemoglobin deficit for the nonhydropic fetuses and a significant negative correlation between these two parameters for the hydropic fetuses . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red blood cell",
"pos": [
7,
21
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
133,
143
]
} |
the relation of fetal growth and maternal oxygen transport as assessed by red blood cell 2,3-diphosphoglycerate , hemoglobin oxygen affinity , hemoglobin , ph , and pco2 was evaluated in 21 pregnant women . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red",
"pos": [
74,
77
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
143,
153
]
} |
it appears that fetal growth is related to the maternal red blood cell oxygen transport parameters 2,3-diphosphoglycerate/hemoglobin molar ratio and hemoglobin oxygen affinity . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red blood cell",
"pos": [
56,
70
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
149,
159
]
} |
the enhanced oxidation of hb at acidic ph was not due simply to increased membrane permeability by the uncharged species ( hoscn ) , since both erythrocyte lysate hb and purified hb were oxidized to the same extent at low ph as were intact erythrocytes . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
144,
155
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
179,
181
]
} |
in bioartificial pancreatic systems , isolated islets of langerhans are protected against immune rejection by an artificial membrane , permeable to glucose and insulin , but not to immunoglobulins and lymphocytes . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islets of langerhans",
"pos": [
47,
67
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
160,
167
]
} |
this is the third reported case of rcc in a patient with vhl in which loss of a portion of the short arm of chromosome 3 ( 3p ) has occurred . | tissue_is_expression_site_of_gene_product | {
"id": "C0022646",
"name": "rcc",
"pos": [
35,
38
]
} | {
"id": "C0299505",
"name": "vhl",
"pos": [
57,
60
]
} |
we show here that igd molecules are noncovalently associated in the b cell membrane with a heterodimer consisting of two proteins of 35 kd ( igd-alpha ) and 39 kd ( ig-beta ) , respectively . | tissue_is_expression_site_of_gene_product | {
"id": "C0004561",
"name": "b cell",
"pos": [
68,
74
]
} | {
"id": "C0104979",
"name": "ig-beta",
"pos": [
165,
172
]
} |
furthermore , zs cells expressed a typical t-cell surface structure , the cd2 molecule , detectable by a variety of different anti-cd2 monoclonal antibodies ( mabs ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t-cell",
"pos": [
43,
49
]
} | {
"id": "C0108773",
"name": "cd2 molecule",
"pos": [
74,
86
]
} |
to define further the basis of t cell function in the inductive and effector limbs of the normal intestinal immune system , the capacity of mucosal lymphocytes to produce and use lymphokines and their effects on regulation of ig production were determined in normal nonhuman primates . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
148,
159
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
179,
190
]
} |
development of a novel substrate capture immunoassay for the detection of a neutral metalloproteinase capable of degrading basement membrane ( type iv ) collagen . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
123,
140
]
} | {
"id": "C0009333",
"name": "type iv",
"pos": [
143,
150
]
} |
interactions between self-mhc molecules and t cells are necessary for the proper development of mature t cells , in part due to an absolute requirement for self-mhc-tcr interactions . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
44,
51
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
165,
168
]
} |
the primary structure of ovine hypothalamic hypophysiotropic luteinizing hormone-releasing factor , lrf , has been established as pglu-his-trp-ser-tyr-gly-leu-arg-pro-gly-nh ( 2 ) by hydrolysis of the peptide with chymotrypsin or pyrrolidone-carboxylylpeptidase and by analysis of the products by an edman-dansylation sequencing technique , as well as by mass spectrometry of the derived phenylthiohydantoins . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "structure",
"pos": [
12,
21
]
} | {
"id": "C0023610",
"name": "lrf",
"pos": [
100,
103
]
} |
release of lh by the pituitary in vivo in response to crude ovine hypothalamic extract or purified porcine gonadotrophin releasing factor . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
66,
78
]
} | {
"id": "C0023610",
"name": "gonadotrophin releasing factor",
"pos": [
107,
137
]
} |
[ morphology of the terminal nervous system of the islands of langerhans in normal conditions and under stimulation with insulin-active hormones ] . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "of",
"pos": [
13,
15
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
121,
128
]
} |
rbc and haemoglobin were higher in the former group , but the difference was not statistically significant . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
0,
3
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
8,
19
]
} |
one alternative explanation described here is that there is no preexisting foreign antigen-mhc antigen complex prior to interaction with t cells , and it is the t cells that cause the two moieties to become associated for recognition by a single antigen-specific t cell receptor . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
137,
144
]
} | {
"id": "C0034790",
"name": "t cell receptor",
"pos": [
263,
278
]
} |
pancreatic endocrine cells were stained immunocytochemically for insulin , glucagon , somatostatin and pancreatic polypeptide by the pap technique or sequentially for two hormones by the pap followed by an indirect immunogold procedure . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic endocrine",
"pos": [
0,
20
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
65,
72
]
} |
seven frozen skin biopsies of ks from five elderly mediterranean people and one renal allograft recipient were labelled , using an immunoperoxidase technique , for basement membrane-specific macromolecules , laminin and type iv-collagen . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
164,
181
]
} | {
"id": "C0009333",
"name": "type iv-collagen",
"pos": [
220,
236
]
} |
clinical signs of puberty are preceded by increased pulsatile secretion of hypothalamic gonadotropin-releasing hormone ( gnrh ) followed by increased pituitary responsiveness to gnrh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
75,
87
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
178,
182
]
} |
hypothalamic hypogonadism can be considered a disorder of the hypothalamic gnrh pulse generator that results in deficient or dysrhythmic gnrh release . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
0,
12
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
137,
141
]
} |
in the liver of the poisoned animals , the glycogen level and the aspat and alat activities , while in the serum the total protein and the fractions albumin , alpha 1-globulin and gamma-globulin significantly decreased ; | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
7,
12
]
} | {
"id": "C0017007",
"name": "gamma-globulin",
"pos": [
180,
194
]
} |
serum concentrations of two basement membrane proteins , laminin and collagen type iv , were studied in three spontaneously metastasising experimental tumors : 3ll lewis lung and b16 melanoma of the mouse and r3230 adenocarcinoma of the rat . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
28,
45
]
} | {
"id": "C0009333",
"name": "collagen",
"pos": [
69,
77
]
} |
utilizing the ria , we demonstrated that the hypothalamic grf content in rats which received monosodium glutamate during the neonatal period was less than 20 % of that of controls . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
45,
57
]
} | {
"id": "C0037668",
"name": "grf",
"pos": [
58,
61
]
} |
however , the hypothalamic grf content was not altered in rats made hypothyroid by methimazole administration , another condition known to greatly impair gh secretion . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
14,
26
]
} | {
"id": "C0037668",
"name": "grf",
"pos": [
27,
30
]
} |
we have investigated the distribution of the basement membrane proteins laminin and type iv collagen , and the intermediate filament proteins vimentin and prekeratin , in these three cell types using immunofluorescence techniques . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement",
"pos": [
45,
53
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
84,
100
]
} |
reduced glutathione ( gsh ) , gsh stability and glucose-6-phosphate dehydrogenase ( g6pd ) activity in fractionated red cells decreased with age , while oxidized glutathione ( gssg ) and methemoglobin ( methb ) increased with age . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
116,
125
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
187,
200
]
} |
macrophages challenged with ifn-alpha , ifn-beta , mdp , and bestatin did not exhibit increased 158.2 and also failed to acquire tumoricidal activity when treated concomitantly with lps . | tissue_is_expression_site_of_gene_product | {
"id": "C0024432",
"name": "macrophages",
"pos": [
0,
11
]
} | {
"id": "C0015980",
"name": "ifn-beta",
"pos": [
40,
48
]
} |
ninety-three percent of aspirated primary and secondary prostatic tumors stained positively for psap compared with 81 % for psa . | tissue_is_expression_site_of_gene_product | {
"id": "C0033572",
"name": "prostatic",
"pos": [
56,
65
]
} | {
"id": "C0138741",
"name": "psa",
"pos": [
124,
127
]
} |
the pseudo-basement membrane , which links this intercellular matrix to the underlying reticular layer , contains rich deposits of fibronectin and type iii collagen along with more restricted foci of laminin and type iv collagen . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
11,
28
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
212,
228
]
} |
erythrocyte sorbitol dehydrogenase activity was significantly lower for 34 diabetic patients ( mean +/- sd : 0.219 +/- 0.085 u min-1 g hb-1 ) than for 27 normal blood donors ( 0.34 +/- 0.094 u min-1 g hb-1 ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
0,
11
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
201,
203
]
} |
the inhibitory action of melatonin is most likely exerted at the hypothalamic level , possibly through interference with the control of pulsatile secretion of gonadotropin-releasing hormone . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
65,
77
]
} | {
"id": "C0023610",
"name": "gonadotropin-releasing hormone",
"pos": [
159,
189
]
} |
pituitary growth hormone and hypothalamic somatostatin in young female rats versus old constant estrous female rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
29,
41
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
42,
54
]
} |
pituitary content and concentration of growth hormone was significantly reduced , and hypothalamic somatostatin content significantly increased , in old constant estrous as compared to young female rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
86,
98
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
99,
111
]
} |
these results indicate that human prostatic tissue contains only one form of 5 alpha-reductase , which is located exclusively in the nucleus . | tissue_is_expression_site_of_gene_product | {
"id": "C0033572",
"name": "prostatic",
"pos": [
34,
43
]
} | {
"id": "C0039602",
"name": "5 alpha-reductase",
"pos": [
77,
94
]
} |
the reproductive capacities of 35 patients with hodgkin 's disease were assessed before treatment by semen evaluation and determination of basal hypothalamic-hypophyseal function and after stimulation with gonadotropin-releasing hormone ( gnrh ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
145,
157
]
} | {
"id": "C0023610",
"name": "gonadotropin-releasing hormone",
"pos": [
206,
236
]
} |
the inhibition is selective for the response of eosinophils to delayed ecf-a , which had been isolated from 24-hr-old inflamed skin lesions induced by dnp-ascaris extract in sensitized animals and had been confirmed as being a t lymphocyte-derived lymphokine . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocyte",
"pos": [
229,
239
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
248,
258
]
} |
ectopic beta-hcg is identical in its gel exclusion and high-performance liquid chromatographic properties to placental beta-hcg and , in radioimmunoassay , yields a dilution curve parallel to that of placental beta-hcg . | tissue_is_expression_site_of_gene_product | {
"id": "C0032043",
"name": "placental",
"pos": [
109,
118
]
} | {
"id": "C0106132",
"name": "beta-hcg",
"pos": [
210,
218
]
} |
the distribution of mrna with high sequence homology to somatostatin mrna within the periventricular hypothalamus of rat was assessed using in situ hybridization techniques with synthetic oligodeoxyribonucleotide probes , complementary to the 3 ' coding region of rat somatostatin mrna . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
101,
113
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
268,
280
]
} |
our results show that the peri- and paraventricular hypothalamus is rich in transcripts putatively coding for somatostatin and that these transcripts are co-distributed with neurons immunoreactive with antisomatostatin immunoglobulin . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
52,
64
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
206,
218
]
} |
therefore , we studied the response of 17 hypogonadal men , 8 with a diagnosis of hh ( age , 15.5-41 ; bone age , 12.5-19 yr ; testes , 1-4 ml ) and 9 with cd ( age , 14.5-20 ; bone age , 11-15 yr , testes , 2-10 ml ) to pulsatile gnrh stimulation . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hh",
"pos": [
82,
84
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
231,
235
]
} |
these results indicate significantly lower pituitary lh reserve in patients with permanent hh after short term priming of the pituitary by pulsatile gnrh administration . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hh",
"pos": [
91,
93
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
149,
153
]
} |
the ability of thyroid lymphocytes to secrete immunoglobulins , including thyroid microsomal or thyroglobulin autoantibodies , was markedly reduced in lymphocyte suspensions obtained from patients treated with carbimazole compared with suspensions from patients treated with propranolol . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
15,
22
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
96,
109
]
} |
in the present work , we examined the mechanisms by which macrophage fc receptors must be engaged for macrophages to signal lymphocytes to elaborate the lymphokine . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
124,
135
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
153,
163
]
} |
additional studies indicate that felv-uv impairs il 2 production only if added very soon after lymphocyte contact with lymphokine-inducing agents and that il 2 secretion resumes when felv-uv is removed from the culture . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocyte",
"pos": [
95,
105
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
119,
129
]
} |
addition of tpa to conditioned medium of hep g2 and endothelial cells that has been depleted of tpa and urokinase reveals a 100 kilodalton tpa-inhibitor complex . | tissue_is_expression_site_of_gene_product | {
"id": "C0225336",
"name": "endothelial",
"pos": [
52,
63
]
} | {
"id": "C0032144",
"name": "tpa",
"pos": [
139,
142
]
} |
addition of tpa to conditioned medium of hep g2 and endothelial cells that has been depleted of tpa and urokinase reveals a 100 kilodalton tpa-inhibitor complex . | tissue_is_expression_site_of_gene_product | {
"id": "C0225336",
"name": "endothelial",
"pos": [
52,
63
]
} | {
"id": "C0042071",
"name": "urokinase",
"pos": [
104,
113
]
} |
these results show that the rat median eminence differs from the hypothalamus as a whole in containing ss14 and ss28 in almost equimolar concentrations . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
65,
77
]
} | {
"id": "C0037659",
"name": "ss14",
"pos": [
103,
107
]
} |
2 ) hypothalamic lhrh , pituitary lh and follicle-stimulating hormone ( fsh ) concentrations are unaffected , but testicular t content is reduced ( p less than or equal to 0.001 ) ; | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
4,
16
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
17,
21
]
} |
the distribution of basement membrane ( bm ) markers , type iv collagen , laminin ( lm ) , heparan sulphate proteoglycan ( hsp ) and fibronectin ( fn ) has been studied by indirect immunofluorescence using specific antibodies , in tumoural pathology . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
20,
37
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
55,
71
]
} |
the assay was used in developing a method for the solubilization of human prostatic 5 alpha-reductase . | tissue_is_expression_site_of_gene_product | {
"id": "C0033572",
"name": "prostatic",
"pos": [
74,
83
]
} | {
"id": "C0039602",
"name": "5 alpha-reductase",
"pos": [
84,
101
]
} |
homogenisation conditions were devised under which 95 % of the total prostatic 5 alpha-reductase was released into the microsomal fraction . | tissue_is_expression_site_of_gene_product | {
"id": "C0033572",
"name": "prostatic",
"pos": [
69,
78
]
} | {
"id": "C0039602",
"name": "5",
"pos": [
79,
80
]
} |
we conclude that the lymphocytes of patients with aids , although capable of undergoing a normal degree of blast transformation and lymphokine production after mitogenic stimulation , have an intrinsic defect in their ability to recognize and respond to soluble antigen . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
21,
32
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
132,
142
]
} |
in human fetus , newborn , infant and adult hypothalami , antibodies to ovine corticoliberin-41 stain a paraventriculo-infundibular neuroglandular pathway . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalami",
"pos": [
44,
55
]
} | {
"id": "C0010132",
"name": "corticoliberin",
"pos": [
78,
92
]
} |
we have analyzed the dnasei sensitivity of chromatin from the rat albumin and alpha-fetoprotein genes in the fetal liver ( which synthesizes albumin and alpha-fetoprotein ) , adult liver ( which synthesizes albumin ) , fetal yolk sac ( which synthesizes alpha-fetoprotein ) , and adult kidney ( which synthesizes neither ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
115,
120
]
} | {
"id": "C0002210",
"name": "alpha-fetoprotein",
"pos": [
254,
271
]
} |
active genes were much more sensitive than their kidney counterparts , and the adult liver alpha-fetoprotein and fetal yolk sac albumin genes showed intermediate levels of sensitivity . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
85,
90
]
} | {
"id": "C0002210",
"name": "alpha-fetoprotein",
"pos": [
91,
108
]
} |
hl60 cells preincubated with lymphocyte-derived lymphokines or ifn-alpha also stimulated a significantly better in vitro allogeneic response in the mixed leukocyte reaction than untreated hl60 cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocyte",
"pos": [
29,
39
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
48,
59
]
} |
total insulin output by the in situ islet cell mass and by the heterotopically transplanted islet cell mass was studied by measuring insulin in the portal vein prior to pancreatectomy and two weeks after grafting . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet cell",
"pos": [
36,
46
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
133,
140
]
} |
in order to investigate the possible influence of prolactin ( prl ) at the hypothalamic level , serum lh and fsh pulsatility was studied in 16 male patients with prolactinomas , normally lh responders to gnrh ( group a ) : 8 of them were untreated ( group a1 ) and 8 had undergone previous unsuccessful pituitary treatments ( group a2 ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
75,
87
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
204,
208
]
} |
protective immunity to rickettsia tsutsugamushi in a murine model is dependent upon the development of cell mediated immunity , as demonstrated by lymphocyte transfer , production of lymphokines and -interferon by thymus-derived lymphocytes , activation of macrophages by lymphokines and demonstration of delayed-type hypersensitivity response following exposure to these organisms . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocyte",
"pos": [
147,
157
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
272,
283
]
} |
in the red cell , the heme iron is maintained in the reduced form by the methemoglobin reduction system . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
7,
15
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
73,
86
]
} |
when methemoglobinemia is of hereditary nature , either due to deficiency of red cell nadh-methemoglobin reductase or due to the presence of m hemoglobin , it is a lifelong problem . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
77,
85
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
91,
104
]
} |
the present series of experiments was conducted in an attempt to correlate previously reported dose-dependent and site-selective inhibitory effects of an antiestrogen , ci-628 , on 17 beta-estradiol ( e2 ) -receptor interactions in the anterior pituitary gland ( ap ) and hypothalamus with its effects on the preovulatory surges of luteinizing hormone ( lh ) , follicle-stimulating hormone ( fsh ) , and prolactin . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "anterior pituitary gland",
"pos": [
236,
260
]
} | {
"id": "C0033371",
"name": "prolactin",
"pos": [
404,
413
]
} |
contrastingly , the ap prolactin response to trh was suppressed only in rats given 0.20 mg/kg ci-628 . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "ap",
"pos": [
20,
22
]
} | {
"id": "C0033371",
"name": "prolactin",
"pos": [
23,
32
]
} |
contrastingly , the ap prolactin response to trh was suppressed only in rats given 0.20 mg/kg ci-628 . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "ap",
"pos": [
20,
22
]
} | {
"id": "C0040160",
"name": "trh",
"pos": [
45,
48
]
} |
thus , spontaneous and p4-induced lh surges should be associated with acute changes in lhrh content of discrete hypothalamic areas associated with lhrh cell bodies and/or lhrh axon terminals . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
112,
124
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
171,
175
]
} |
discrete hypothalamic distribution of luteinizing hormone-releasing hormone ( lhrh ) content and of lhrh-degrading activity in laying and nonlaying hens . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
9,
21
]
} | {
"id": "C0023610",
"name": "luteinizing hormone-releasing hormone",
"pos": [
38,
75
]
} |
hypothalamic enzymatic luteinizing hormone-releasing hormone ( lhrh ) -degrading activity ( lhrh-da ) may play a physiologic role in the neuroendocrine control of lhrh in mammals . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
0,
12
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
163,
167
]
} |
the lhrh content in discrete hypothalamic samples of laying and nonlaying hens was correlated to their lhrh-da . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
29,
41
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
103,
107
]
} |
this suggests other mechanisms i.e . marrow function or red-cell loss in hd may be the reason for the lower haemoglobin in this group . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red-cell",
"pos": [
56,
64
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
108,
119
]
} |
measurements of the ontogeny of hematological variants and enzymes in normal development , using additional untreated nestlings , revealed decreases in red blood cell alad , plasma aspartate amino transferase , lactate dehydrogenase , brain dna and rna and liver dna , whereas hematocrit , hemoglobin , plasma alkaline phosphatase , brain monoamine oxidase , brain alad and liver alad increased during the first 10 days of posthatching development . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red",
"pos": [
152,
155
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
290,
300
]
} |
glycine methylester ( 1.0-10.0 mm ) inhibited , in a dose-related manner , transglutaminase activity in rat pancreatic islet homogenates , decreased [ 14c ] methylamine incorporation into endogenous proteins of intact islets , and caused a rapid and reversible inhibition of insulin release evoked by d-glucose , while failing to affect d- [ u-14c ] glucose oxidation . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islet",
"pos": [
108,
124
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
275,
282
]
} |
we employed a short term system of dispersed adult mouse hypothalamic cells , as previously described in the rat , to examine the roles of calcium and calmodulin in srif release . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
57,
69
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
165,
169
]
} |
three chemically distinct groups of calmodulin inhibitors were employed to study the role of calmodulin in stimulus-secretion coupling of hypothalamic srif . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
138,
150
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
151,
155
]
} |
these data demonstrate the role of calcium in membrane depolarization-induced stimulus-secretion coupling of mouse hypothalamic srif . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
115,
127
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
128,
132
]
} |
growth of normal human t lymphocytes induced by monoclonal antibody to the t cell antigen receptor . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t lymphocytes",
"pos": [
23,
36
]
} | {
"id": "C0034790",
"name": "t",
"pos": [
95,
96
]
} |
splenic lymphoid cells from diabetic ( d ) , diabetes-prone ( dp ) , and diabetes-resistant ( dr ) bb/w rats were incubated for 2 days with monolayer cultures of major histocompatibility complex ( mhc ) -compatible wistar-furth ( wf ) rat islet cells or a rat islet cell line ( rin ) , and islet beta cell survival was determined by measuring insulin content in the cultures . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet",
"pos": [
239,
244
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
343,
350
]
} |
d splenic lymphoid cells significantly decreased insulin content in wf rat islet ( -32 % ) and rin cultures ( -77 % ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "cells",
"pos": [
19,
24
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
49,
56
]
} |
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