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README.md
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### Source Data
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#### Data Collection and Processing
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## Citation
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**BibTeX:**
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@article{KoehlerLeman2023,
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title = {Sequence-structure-function relationships in the microbial protein universe},
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volume = {14},
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ISSN = {2041-1723},
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url = {http://dx.doi.org/10.1038/s41467-023-37896-w},
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DOI = {10.1038/s41467-023-37896-w},
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number = {1},
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journal = {Nature Communications},
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publisher = {Springer Science and Business Media LLC},
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author = {Koehler Leman, Julia and Szczerbiak, Pawel and Renfrew, P. Douglas and Gligorijevic, Vladimir and Berenberg, Daniel and Vatanen, Tommi and Taylor, Bryn C. and Chandler, Chris and Janssen, Stefan and Pataki, Andras and Carriero, Nick and Fisk, Ian and Xavier, Ramnik J. and Knight, Rob and Bonneau, Richard and Kosciolek, Tomasz},
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year = {2023},
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month = apr
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}
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## Dataset Card Authors
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### Source Data
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Sequences were obtained from the Genomic Encyclopedia of Bacteria and Archaea
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([GEBA1003](https://genome.jgi.doe.gov/portal/geba1003/geba1003.info.html)) reference
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genome database across the microbial tree of life:
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> **1,003 reference genomes of bacterial and archaeal isolates expand coverage of the tree of life**
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> We present 1,003 reference genomes that were sequenced as part of the Genomic Encyclopedia of Bacteria
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> and Archaea (GEBA) initiative, selected to maximize sequence coverage of phylogenetic space.
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> These genomes double the number of existing type strains and expand their overall phylogenetic
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> diversity by 25%. Comparative analyses with previously available finished and draft genomes reveal
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> a 10.5% increase in novel protein families as a function of phylogenetic diversity. The GEBA genomes
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> recruit 25 million previously unassigned metagenomic proteins from 4,650 samples, improving their
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> phylogenetic and functional interpretation. We identify numerous biosynthetic clusters and experimentally
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> validate a divergent phenazine cluster with potential new chemical structure and antimicrobial activity.
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> This Resource is the largest single release of reference genomes to date. Bacterial and archaeal isolate
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> sequence space is still far from saturated, and future endeavors in this direction will continue to be a
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> valuable resource for scientific discovery.
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#### Data Collection and Processing
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## Citation
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@article{KoehlerLeman2023,
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title = {Sequence-structure-function relationships in the microbial protein universe},
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volume = {14},
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ISSN = {2041-1723},
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url = {http://dx.doi.org/10.1038/s41467-023-37896-w},
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DOI = {10.1038/s41467-023-37896-w},
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number = {1},
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journal = {Nature Communications},
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publisher = {Springer Science and Business Media LLC},
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author = {Koehler Leman, Julia and Szczerbiak, Pawel and Renfrew, P. Douglas and Gligorijevic, Vladimir and Berenberg, Daniel and Vatanen, Tommi and Taylor, Bryn C. and Chandler, Chris and Janssen, Stefan and Pataki, Andras and Carriero, Nick and Fisk, Ian and Xavier, Ramnik J. and Knight, Rob and Bonneau, Richard and Kosciolek, Tomasz},
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year = {2023},
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month = apr
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}
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## Dataset Card Authors
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