---
dataset_info:
  features:
  - name: A
    dtype: string
  - name: B
    dtype: string
  - name: SeqA
    dtype: string
  - name: SeqB
    dtype: string
  splits:
  - name: combined
    num_bytes: 4506410
    num_examples: 6254
  - name: combined_stringent
    num_bytes: 4131280
    num_examples: 5858
  - name: manual
    num_bytes: 2411342
    num_examples: 2150
  - name: manual_stringent
    num_bytes: 2197429
    num_examples: 1970
  - name: pdb
    num_bytes: 2116596
    num_examples: 4140
  - name: pdb_stringent
    num_bytes: 1943225
    num_examples: 3904
  download_size: 8538939
  dataset_size: 17306282
configs:
- config_name: default
  data_files:
  - split: combined
    path: data/combined-*
  - split: combined_stringent
    path: data/combined_stringent-*
  - split: manual
    path: data/manual-*
  - split: manual_stringent
    path: data/manual_stringent-*
  - split: pdb
    path: data/pdb-*
  - split: pdb_stringent
    path: data/pdb_stringent-*
---


# Non-interacting protein pairs from NEGATOME2.0

[Website](https://mips.helmholtz-muenchen.de/proj/ppi/negatome/)

[Paper](https://pmc.ncbi.nlm.nih.gov/articles/PMC3965096/)

We map Uniprot ids with the [ID mapping tool](https://www.uniprot.org/id-mapping) and record entires in which both sequences are found. PFAM entires are ommitted.
Each split corresponds to a section of the dataset, labeled the same as the image below:


![image/png](https://cdn-uploads.huggingface.co/production/uploads/62f2bd3bdb7cbd214b658c48/QpVyar13tdj8J_eSUj2BR.png)


Please cite their paper if you use this dataset in your work

```
@article{Blohm2013,
  title = {Negatome 2.0: a database of non-interacting proteins derived by literature mining,  manual annotation and protein structure analysis},
  volume = {42},
  ISSN = {1362-4962},
  url = {http://dx.doi.org/10.1093/nar/gkt1079},
  DOI = {10.1093/nar/gkt1079},
  number = {D1},
  journal = {Nucleic Acids Research},
  publisher = {Oxford University Press (OUP)},
  author = {Blohm,  Philipp and Frishman,  Goar and Smialowski,  Pawel and Goebels,  Florian and Wachinger,  Benedikt and Ruepp,  Andreas and Frishman,  Dmitrij},
  year = {2013},
  month = nov,
  pages = {D396–D400}
}
```