passages.id: 9575
passages.type: title
passages.text: Phenytoin induced fatal hepatic injury.
passages.id: 9576
passages.type: abstract
passages.text: A 61 year old female developed fatal hepatic failure after phenytoin administration. A typical multisystem clinical pattern precedes the manifestations of hepatic injury. The hematologic, biochemical and pathologic features indicate a mixed hepatocellular damage due to drug hypersensitivity. In a patient receiving phenytoin who presents a viral-like illness, early recognition and discontinuation of the drug are mandatory.