passages.id: 15022
passages.type: title
passages.text: Acetazolamide-induced nephrolithiasis: implications for treatment of neuromuscular disorders.
passages.id: 15023
passages.type: abstract
passages.text: Carbonic anhydrase inhibitors can cause nephrolithiasis. We studied 20 patients receiving long-term carbonic anhydrase inhibitor treatment for periodic paralysis and myotonia. Three patients on acetazolamide (15%) developed renal calculi. Extracorporeal lithotripsy successfully removed a renal calculus in one patient and surgery removed a staghorn calculus in another, permitting continued treatment. Renal function remained normal in all patients. Nephrolithiasis is a complication of acetazolamide but does not preclude its use.