passages.id: 1110
passages.type: title
passages.text: Recurrent reversible acute renal failure from amphotericin.
passages.id: 1111
passages.type: abstract
passages.text: A patient with cryptogenic cirrhosis and disseminated sporotrichosis developed acute renal failure immediately following the administration of amphotericin B on four separate occasions. The abruptness of the renal failure and its reversibility within days suggests that there was a functional component to the renal dysfunction. We propose that amphotericin, in the setting of reduced effective arterial volume, may activate tubuloglomerular feedback, thereby contributing to acute renal failure.