diff --git a/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/5smAuOfTr-M.srt b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/5smAuOfTr-M.srt new file mode 100644 index 0000000000000000000000000000000000000000..762977760fd75558d7aece59e87a66c298bb78b4 --- /dev/null +++ b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/5smAuOfTr-M.srt @@ -0,0 +1,1483 @@ +1 +00:00:05,800 --> 00:00:12,120 +السلام عليكم و رحمة الله و بركاته اليوم + +2 +00:00:12,120 --> 00:00:14,440 +إن شاء الله محاضرتنا على الـ Hybrid-OMA Technique + +3 +00:00:18,150 --> 00:00:27,010 +و موضوع بدأ ينحكي فيه في الـ 1975 لما بدأت الإعلانات + +4 +00:00:27,010 --> 00:00:32,870 +اثنين two scientist كوهلر و مايلدستاين بدءا يعملوا + +5 +00:00:32,870 --> 00:00:37,770 +fusion في الـ lymphocytes يعني يدمجوا lymphocyte مع + +6 +00:00:37,770 --> 00:00:42,030 +بعضها طبعا ما حصل هذا الكلام production of cell + +7 +00:00:42,030 --> 00:00:49,130 +line من خصائصه أنه immortal بمعنى أنه يبقى موجود + +8 +00:00:49,130 --> 00:00:54,710 +دائما و ينتج انتباد محدث انتباد محدث انتباد محدث + +9 +00:00:54,710 --> 00:00:56,370 +انتباد محدث انتباد محدث انتباد محدث انتباد محدث + +10 +00:00:56,370 --> 00:00:56,470 +انتباد محدث انتباد محدث انتباد محدث انتباد محدث + +11 +00:00:56,470 --> 00:00:58,170 +انتباد محدث انتباد محدث انتباد محدث انتباد محدث + +12 +00:00:58,170 --> 00:00:58,210 +انتباد محدث انتباد محدث انتباد محدث انتباد محدث + +13 +00:00:58,210 --> 00:00:59,010 +انتباد محدث انتباد محدث انتباد محدث انتباد محدث + +14 +00:00:59,010 --> 00:01:03,370 +انتباد محدث انتباد محدث انتباد محدث انتباد + +15 +00:01:03,370 --> 00:01:10,610 +محدث انتباد + +16 +00:01:10,610 --> 00:01:15,830 +لكن لم يستغل هذا التقنيك لغاية 1987 يوم ما بدءوا + +17 +00:01:15,830 --> 00:01:20,590 +يفكروا يستخدموا الـ monoclonal antibody in + +18 +00:01:20,590 --> 00:01:28,930 +diagnostic techniques in + +19 +00:01:28,930 --> 00:01:34,490 +a specific immune response أول ما هي طبعا خلايا + +20 +00:01:34,490 --> 00:01:37,870 +التي قالتلي تتنشط عند دخول الـ antigen هي عبارة عن + +21 +00:01:37,870 --> 00:01:42,880 +كوكتيل من الـ B و T lymphocytes وطبعا الـ figure واضح + +22 +00:01:42,880 --> 00:01:50,680 +جدا أن هناك كوكتيل من الـ B و T lymphocytes يتصدى + +23 +00:01:50,680 --> 00:01:54,300 +للأنتجين هذا الانتجين من صفاته أنه يحتوي على أزرق + +24 +00:01:54,300 --> 00:01:58,120 +واحد و أحمر اثنين في الانتجين وبالتالي الخلايا التي + +25 +00:01:58,120 --> 00:02:02,400 +تصدت لهذا الـ lymphocyte هي الخلايا الزرقاء والحمراء + +26 +00:02:02,400 --> 00:02:07,900 +التي تحتوي على مستضد محددة للـ lymphocyte وصار حاجة + +27 +00:02:07,900 --> 00:02:12,660 +بيسموها في السابق Clonal Selection لهذه الخلايا + +28 +00:02:12,660 --> 00:02:18,600 +اللي بعدها هي صار في Clonal Expansion فهذه زي ما + +29 +00:02:18,600 --> 00:02:22,320 +أنتم شايفين الخلايا الزرقاء والخلايا الحمراء صار + +30 +00:02:22,320 --> 00:02:27,500 +لها Clonal Expansion after selection صار في + +31 +00:02:27,500 --> 00:02:31,640 +expansion وصار في عندي many many cells which have + +32 +00:02:31,640 --> 00:02:36,460 +the same specificity for the two epitopes involved + +33 +00:02:39,120 --> 00:02:42,560 +المحصلة في هذه الحالة هو إنتاج Polyclonal Antibody + +34 +00:02:42,560 --> 00:02:47,620 +لأنه صار في عندي أكثر من Epitopes للـ Antigen تصدت + +35 +00:02:47,620 --> 00:02:52,060 +إليه أكثر من خلية وكل خلية طلعت لنا Antibody for + +36 +00:02:52,060 --> 00:02:54,920 +specific Epitope فصار كوكتيل من الـ Epitopes + +37 +00:02:54,920 --> 00:03:01,520 +موجودين فالمحصلة إنتاج Polyclonal Antibody عشان هي + +38 +00:03:01,520 --> 00:03:05,920 +كذا يوم ما يصير فيه immunization لأي animal with a + +39 +00:03:05,920 --> 00:03:12,680 +protein عدد كبير من الـ B-lymphocyte سيكون مدفع على + +40 +00:03:12,680 --> 00:03:17,820 +الانتبروتين انتبوتين انتبوتين انتبوتين انتبوتين + +41 +00:03:17,820 --> 00:03:19,560 +انتبوتين انتبوتين انتبوتين انتبوتين انتبوتين + +42 +00:03:19,560 --> 00:03:22,220 +انتبوتين انتبوتين انتبوتين انتبوتين انتبوتين + +43 +00:03:22,220 --> 00:03:31,120 +انتبوتين انتبوتين انتبوتين انتبوتين انتبوتين + +44 +00:03:31,120 --> 00:03:33,800 +انتبوتين انتبوتين انتبوتين انتبوتين انتبوتين + +45 +00:03:33,800 --> 00:03:34,200 +انتبوتين انتبوتين انتبوتين انتبوتين انتبوتين + +46 +00:03:34,200 --> 00:03:35,580 +انتبوتين انتبوتين انتبوتين انتبوتين انتب may have + +47 +00:03:35,580 --> 00:03:41,500 +different antigen binding sites بمعنى آخر they may + +48 +00:03:41,500 --> 00:03:47,310 +have different affinity to the same epitope المحصلة + +49 +00:03:47,310 --> 00:03:51,950 +أنّه في mixture of antibody produced in response to + +50 +00:03:51,950 --> 00:03:55,790 +that antigen and this these antibodies are called + +51 +00:03:55,790 --> 00:03:59,650 +polyclonal antibody they produced by many + +52 +00:03:59,650 --> 00:04:03,570 +different clones of B lymphocytes طبيعي جدا أن تهيأ + +53 +00:04:03,570 --> 00:04:07,510 +اليوم أن أدخل الـ antigen وزي ما أنتم شايفين فيه أكثر + +54 +00:04:07,510 --> 00:04:12,050 +من Epitopes لأن كل لون بيمثل Epitopes + +55 +00:04:15,100 --> 00:04:21,680 +صح هذا هي الـ Epitopes مختلفة عملنا لها immunization + +56 +00:04:21,680 --> 00:04:27,960 +لـ animal صار في immune response والمحصلة + +57 +00:04:27,960 --> 00:04:33,600 +different B cell have been stimulated وكل واحدة + +58 +00:04:33,600 --> 00:04:38,840 +طلعت Antibody specific for certain Epitopes + +59 +00:04:38,840 --> 00:04:46,360 +والمحصلة كوكتيل من الـ Antibodies سميناها Polyclonal + +60 +00:04:46,360 --> 00:04:52,340 +Antibody يعني a mixture of Antibody وكلهم مرتبطين + +61 +00:04:52,340 --> 00:04:57,520 +بـ Epitopes of the original protein or antigen + +62 +00:04:58,910 --> 00:05:05,150 +طبعا في منهم يرتبط بقوة أكثر من الثاني يعني الـ + +63 +00:05:05,150 --> 00:05:09,190 +affinity to of binding is different these are + +64 +00:05:09,190 --> 00:05:13,050 +called مرة ثانية polyclonal antibody يبقى الـ + +65 +00:05:13,050 --> 00:05:16,270 +polyclonal antibody are a mixture of antibody with + +66 +00:05:16,270 --> 00:05:19,130 +different antigen binding sites and may have + +67 +00:05:19,130 --> 00:05:23,610 +different may bind to different epitopes of + +68 +00:05:23,610 --> 00:05:30,370 +antigen وإن يوم ما يدخل لما نعمل immunization for + +69 +00:05:30,370 --> 00:05:37,190 +certain animal فبتكون هناك antibody for immunizing + +70 +00:05:37,190 --> 00:05:42,590 +agents they have varying affinity and they may + +71 +00:05:42,590 --> 00:05:47,300 +have different classes of antibody السيرام الذي + +72 +00:05:47,300 --> 00:05:51,680 +اكتشفته أيضا بيسموه polyclonal antiserum الـ + +73 +00:05:51,680 --> 00:05:55,000 +polyclonal antiserum بيحتوي على انتيبودي + +74 +00:05:55,000 --> 00:05:59,480 +لإيبيتوبات مختلفة وانتجين مختلفة تحتوي على انتجين + +75 +00:05:59,480 --> 00:06:00,840 +مختلفة تحتوي على انتجين مختلفة تحتوي على انتجين + +76 +00:06:00,840 --> 00:06:01,780 +مختلفة تحتوي على انتجين مختلفة تحتوي على انتجين + +77 +00:06:01,780 --> 00:06:01,860 +مختلفة تحتوي على انتجين مختلفة تحتوي على انتجين + +78 +00:06:01,860 --> 00:06:02,220 +مختلفة تحتوي على انتجين مختلفة تحتوي على انتجين + +79 +00:06:02,220 --> 00:06:09,500 +مختلفة تحتوي على انتجين مختلفة تحتوي على انتجين + +80 +00:06:09,500 --> 00:06:15,910 +مختلفة تحتوي على كيف بيصير عملية الـ purification زي + +81 +00:06:15,910 --> 00:06:19,410 +ما اتخذته في column chromatography ده هو ندخل + +82 +00:06:19,410 --> 00:06:25,590 +beads عليها antigen specific to certain antibody + +83 +00:06:25,590 --> 00:06:28,750 +من أن انتبادى من الانتبادى التي موجودة في الـ + +84 +00:06:28,750 --> 00:06:32,570 +mixture الذي بده اعمله purification فطبعا بعد هيك + +85 +00:06:32,570 --> 00:06:37,050 +بنعمل purification للـ mixture بيدخل على الـ beads + +86 +00:06:37,860 --> 00:06:41,980 +بيرتبط الـ antibody التي بديها which is specific + +87 +00:06:41,980 --> 00:06:48,380 +for the antigen التي موجود على الـ beads والباقي + +88 +00:06:48,380 --> 00:06:53,560 +بنزل الباقي الـ antibody بنزل التي لبروتينات الـ + +89 +00:06:53,560 --> 00:06:58,060 +antibody التي ليس لها it's not specific for that + +90 +00:06:58,060 --> 00:07:02,180 +antigen يبقى احنا في هذه العملية مسكنا one + +91 +00:07:02,180 --> 00:07:07,810 +antibody من mixture of antibodies والباقي نزل بعد + +92 +00:07:07,810 --> 00:07:08,890 +ذلك بناخد الـ beads + +93 +00:07:21,740 --> 00:07:31,280 +طبعا illusion in certain التي هو mixture + +94 +00:07:31,280 --> 00:07:36,340 +ايوه antigen can be bound to the support matrix in + +95 +00:07:36,340 --> 00:07:39,800 +order to purify antigen specific antibody from + +96 +00:07:39,800 --> 00:07:43,940 +polyclonal antiserum طبعا هذه العملية ممكن تتكرر بـ + +97 +00:07:43,940 --> 00:07:47,480 +antigen ثاني specific for antibody برضه في الـ + +98 +00:07:47,480 --> 00:07:50,740 +mixture وشوية شوية بنعمل عملية verification للـ + +99 +00:07:50,740 --> 00:07:55,560 +antibody واحد ولا الثاني هي عندي different B cell + +100 +00:07:55,560 --> 00:07:59,920 +عندها القدرة أن تطلع لي different antibody و + +101 +00:07:59,920 --> 00:08:05,720 +محصلة mixture of antibody طبعا هي احنا ممكن ناخذ + +102 +00:08:05,720 --> 00:08:12,790 +one cell تطلع لي one specific antibody طبعا هذا + +103 +00:08:12,790 --> 00:08:20,430 +الخلية ممكن نعملها culturing وتطلع لي many many + +104 +00:08:20,430 --> 00:08:24,970 +antibody specific to that antigen بعدين بنعمل + +105 +00:08:24,970 --> 00:08:30,600 +harvesting لـ الـ antibody التي طلعت في هذه الحالة + +106 +00:08:30,600 --> 00:08:35,460 +لما باخد خلية بتطلع antibody واحد حصلها monoclonal + +107 +00:08:35,460 --> 00:08:38,080 +antibody بس في مشكلة فيها ده ده مش hybridoma + +108 +00:08:38,080 --> 00:08:41,280 +technique ده عبارة عن خلية أخذناها و زرعناها أو + +109 +00:08:41,280 --> 00:08:44,540 +عملنا لها culturing وطلعتناها antibody طبعا بعد + +110 +00:08:44,540 --> 00:08:48,990 +ما هيجناها بـ antibody هذه طبعا طريقة أخرى من طريقة + +111 +00:08:48,990 --> 00:08:53,450 +الفلصل أن احنا ناخد فينا different cell طلعت له + +112 +00:08:53,450 --> 00:08:56,310 +different antibody طلع عندي mixture of antibody + +113 +00:08:56,310 --> 00:09:00,670 +أخذنا خلية واحدة منها culturing وبتطلعنا إيش + +114 +00:09:00,670 --> 00:09:05,570 +antibody واحد الذي ممكن أن هلاقاش مشكلة في هذه + +115 +00:09:05,570 --> 00:09:09,630 +القضية أن هذه الخلية لها lifespan محدد وبالتالي + +116 +00:09:09,630 --> 00:09:15,150 +هتموت بعد فترة لكن أنا معنى باني احصل على خلية + +117 +00:09:15,150 --> 00:09:20,230 +which is immortal هذا الكلام بيتحقق يوم أعمل + +118 +00:09:20,230 --> 00:09:25,490 +hybridoma تقنية الـ hybridomas كيف بتصير قالوا + +119 +00:09:25,490 --> 00:09:30,750 +الليمفوسايت can mutate into tumor cell أنا ممكن + +120 +00:09:30,750 --> 00:09:34,250 +أجيب ليمفوسايت و أعملها mutation وبالتالي تتحول + +121 +00:09:34,250 --> 00:09:39,830 +لـ tumor cell وطبعا في هذه الحالة بيسموها myeloma + +122 +00:09:39,830 --> 00:09:45,030 +cell وهو عبارة عن cancer of B lymphocytes أو plasma + +123 +00:09:45,030 --> 00:09:50,350 +cell الـ myeloma cell في هذه الحالة become immortal + +124 +00:09:50,350 --> 00:09:53,930 +لأنها صارت tumor و الـ tumor is resistant to + +125 +00:09:53,930 --> 00:09:58,150 +apoptosis وبالتالي can grow indefinitely in + +126 +00:09:58,150 --> 00:10:04,050 +culture media طب شو بتعمل في هذه الحالة عشان أعمل + +127 +00:10:04,050 --> 00:10:07,690 +hybrid هما قالوا بنعمل fusion of a single + +128 +00:10:07,690 --> 00:10:11,930 +activated خلية + +129 +00:10:11,930 --> 00:10:20,830 +محفظة لإنتاج certain antibody بأجيب + +130 +00:10:20,830 --> 00:10:25,630 +هذه الخلية التي عبارة عن activated B cell وبأعمل + +131 +00:10:25,630 --> 00:10:30,130 +fusion لهذه الخلية مع myeloma cell التي أنا عملتها + +132 +00:10:30,130 --> 00:10:35,270 +وبالتالي بأعمل hybridoma وهو عبارة عن بأحصل على خلية + +133 +00:10:35,270 --> 00:10:38,970 +مهجنة that can grow indefinitely in culture media + +134 +00:10:38,970 --> 00:10:44,110 +هذه الخلية بي lymphocytes which can secrete + +135 +00:10:44,110 --> 00:10:46,550 +antibody but do not grow in different tissue + +136 +00:10:46,550 --> 00:10:52,920 +culture وبأجيب myeloma cell وهي زمان كما تشايفين + +137 +00:10:52,920 --> 00:10:58,140 +myeloma cell can grow indefinitely in cell culture + +138 +00:10:58,140 --> 00:11:02,360 +but do not secrete the desired antibody التي فوق + +139 +00:11:02,360 --> 00:11:07,080 +بتطلع لي antibody هادي mutated and cannot secrete + +140 +00:11:07,080 --> 00:11:13,160 +antibody بأعمل fusion بين التنتين هي fusion ثم + +141 +00:11:13,160 --> 00:11:18,540 +بحصل على hybrid oma cell اللي عبارة عن خلية هاجين ما + +142 +00:11:18,540 --> 00:11:23,940 +بين الـ B cell والـ myeloma cell وهذه الخلية can grow + +143 +00:11:23,940 --> 00:11:28,720 +indefinitely in culture media and can secrete + +144 +00:11:28,720 --> 00:11:33,480 +antibody وهي المحصلة والله بأخذ هذه الخلية و + +145 +00:11:33,480 --> 00:11:37,660 +بعملها sub-culturing وبالتالي هذه الخلية can grow + +146 +00:11:37,660 --> 00:11:42,360 +indefinitely و بتطلع لي in the same time + +147 +00:11:49,730 --> 00:11:55,170 +الخلية الـ B lymphocyte اللي احنا حفظناها أو قدمنا + +148 +00:11:55,170 --> 00:12:00,070 +لها انتيجن في البداية فهتكون انتيبادي يبقى + +149 +00:12:00,070 --> 00:12:04,510 +الانتيبادي بيطلع specific for only specific + +150 +00:12:04,510 --> 00:12:08,110 +antigen and this is called monoclonal antibody + +151 +00:12:11,610 --> 00:12:14,190 +يبقى الـ Monoclonal Antibody يبقى أن الانتيبادي + +152 +00:12:14,190 --> 00:12:20,530 +ينتج من أحد كلون من الـ B lymphocyte وحصلنا عليه من + +153 +00:12:20,530 --> 00:12:24,510 +خلال الـ fusion of B cell which secretes the + +154 +00:12:24,510 --> 00:12:29,170 +desired antibody مع myeloma cell which is capable + +155 +00:12:29,170 --> 00:12:33,070 +of growing indefinitely in tissue culture هنحصل + +156 +00:12:33,070 --> 00:12:38,590 +على Monoclonal Antibody which all have identical + +157 +00:12:38,590 --> 00:12:43,810 +antigen binding sites ويمكنهم أيضًا أن يتعاملوا مع + +158 +00:12:43,810 --> 00:12:50,150 +نفسهم مع نفس الـ Epitope مع نفس الـ Affinity وهم + +159 +00:12:50,150 --> 00:12:55,130 +جميعًا من نفس السلفات الانتيبوديية يبقى شوفوا من + +160 +00:12:55,130 --> 00:12:58,990 +صفات الـ Monoclonal Antibody لديهم مجموعة متعاملة + +161 +00:12:58,990 --> 00:13:01,570 +عن تجينية متعاملة متعاملة متعاملة متعاملة متعاملة + +162 +00:13:01,570 --> 00:13:02,370 +متعاملة متعاملة متعاملة متعاملة متعاملة متعاملة + +163 +00:13:02,370 --> 00:13:05,290 +متعاملة متعاملة متعاملة متعاملة متعاملة متعاملة + +164 +00:13:05,290 --> 00:13:06,290 +متعاملة متعاملة متعاملة متعاملة متعاملة متعاملة + +165 +00:13:06,290 --> 00:13:09,310 +متعاملة متعاملة متعاملة متعام + +166 +00:13:10,370 --> 00:13:15,790 +كلهم with the same affinity وكل الـ antibody are + +167 +00:13:15,790 --> 00:13:21,170 +done من نفس الـ class طيب شوفوا الـ procedure + +168 +00:13:21,170 --> 00:13:26,930 +بالتفصيل هنا جبنا فأر وعملنا له immunization و + +169 +00:13:26,930 --> 00:13:33,790 +certain antigen طبعا بعد فترة بناخد الـ spleen بعد + +170 +00:13:33,790 --> 00:13:39,630 +أسبوعين بناخد الـ spleen تبع الفأر هذا وبناخد منه + +171 +00:13:39,630 --> 00:13:45,390 +الخلايا اللي هي الـ B-cell وفي نفس الوقت بنحصل نجيب + +172 +00:13:45,390 --> 00:13:48,610 +tumor cell سواء احنا عملناها أو جيبناها already + +173 +00:13:48,610 --> 00:13:54,290 +tumor بنتنشره culture وبتنتين بعملهم fusion وبحصل + +174 +00:13:54,290 --> 00:13:57,270 +على hybridoma cell بعملها sub-culturing ده هي + +175 +00:13:57,270 --> 00:14:00,590 +hybridoma which can screened for antibody + +176 +00:14:00,590 --> 00:14:06,230 +production ومحصلها monoclonal antibody نفس الصورة x + +177 +00:14:06,230 --> 00:14:11,670 +-antigen isolate spleen cell بعد فترة فتحصل عليها + +178 +00:14:11,670 --> 00:14:17,270 +اللي هو mixture of spleen cell بما فيهم الـ anti x + +179 +00:14:17,270 --> 00:14:23,150 +-antibody cell مع نجيب mutated mutant myeloma line + +180 +00:14:23,150 --> 00:14:30,230 +unable to grow in HAT media الآن هنعرفش يعني HAT و + +181 +00:14:30,230 --> 00:14:33,670 +ما بينتجش Antibody فبنحصل عليها طبعا تلات أنواع من + +182 +00:14:33,670 --> 00:14:37,550 +الخلايا خلايا ما صلحش Fusion وخلايا already صلها + +183 +00:14:37,550 --> 00:14:42,970 +Fusion وصلحت hybridoma وخلايا tumor cell ما صلحلها + +184 +00:14:42,970 --> 00:14:46,790 +Fusion تلات أنواع من الخلايا طبعا هذا الكلام مهم + +185 +00:14:46,790 --> 00:14:51,190 +بيصير في culture سموها media لأن ما عرفش الـ HAT + +186 +00:14:51,190 --> 00:14:56,570 +ماشي و بالتالي الـ aminopterin اللي ما صلح لها + +187 +00:14:56,570 --> 00:15:03,440 +Fusion هتموت بعد فترة و الـ tumor cell برضه هتموت + +188 +00:15:03,440 --> 00:15:07,880 +لأنه لا تستطيع أن تنمو في وسط اللي حطناها فيه + +189 +00:15:07,880 --> 00:15:10,780 +لولها الـ media فبتبقى الـ hybrid هو ما هي اللي + +190 +00:15:10,780 --> 00:15:17,920 +بتبقى عايشة خلايا بتموت تلات أنواع ناخدها بعد هيك + +191 +00:15:17,920 --> 00:15:24,270 +ونعملها sub-culturing و تحصل علاج على خلايا نفس + +192 +00:15:24,270 --> 00:15:28,810 +الصورة هي two cells fused antibody-screening B + +193 +00:15:28,810 --> 00:15:32,810 +lymphocyte hybridoma cell طلعت منها نفس اللي احكي + +194 +00:15:32,810 --> 00:15:43,430 +هو دي صورة لها اللي هو الـ 96 well plate بنعمل فيه + +195 +00:15:43,430 --> 00:15:51,370 +culturing بنخفف اللي هو dilution معين للـ hybridoma + +196 +00:15:51,370 --> 00:15:56,540 +cell line و بنحصل على اللي هي خلايا عديدة و بنعمل + +197 +00:15:56,540 --> 00:16:04,520 +sub-culturing وطول ما هي بتنتج طبعا هي الخلايا + +198 +00:16:04,520 --> 00:16:10,260 +اللي هي في الـ culture tissue culture ممكن نفحصها + +199 +00:16:10,260 --> 00:16:15,790 +by inverted microscope اللي هي خلايا عايشة ولا ميتة + +200 +00:16:15,790 --> 00:16:24,190 +وهكذا وهذه صورة لعملية تخزين لهذه الخلايا في طبعا + +201 +00:16:24,190 --> 00:16:31,090 +اللي هو incubators درجات حرارة متدنية عشان + +202 +00:16:31,090 --> 00:16:39,830 +تنحفظ طيب نيجي للـ hybridoma technique بتفاصيله + +203 +00:16:41,380 --> 00:16:45,540 +أول شيء myeloma cell هف بين genetically engineered + +204 +00:16:45,540 --> 00:16:52,640 +ماشي لعبوا فيها genetically بحيث أن these cell + +205 +00:16:52,640 --> 00:16:58,280 +they cannot use hypoxanthine aminopterin thymidine + +206 +00:16:58,280 --> 00:17:03,960 +لكل HAT media يعني لو حطناها في HAT media ما بتقدر + +207 +00:17:03,960 --> 00:17:08,020 +تنمو في هذا الـ medium و هدول nucleobase اللي هو + +208 +00:17:08,020 --> 00:17:14,510 +nucleoprotein أو nucleoprotein فيهم ما نعملها و نحطها + +209 +00:17:14,510 --> 00:17:19,710 +في الـ culture يحتوي على هذه المواد ما تستطيع أن + +210 +00:17:19,710 --> 00:17:22,670 +تمويلها لعبنا فيها genetically أخذوا منها انزايم + +211 +00:17:22,670 --> 00:17:28,130 +عندنا هنشوف ايش هو الانزيم طيب الحاجة الثانية + +212 +00:17:28,130 --> 00:17:31,800 +only be cells that have fused with the engineered + +213 +00:17:31,800 --> 00:17:34,760 +myeloma cell will survive بقى الـ hybrid myeloma + +214 +00:17:34,760 --> 00:17:38,500 +cell اللي طلعت اللي هي اللي بتستطيع أنها عايش تنمو + +215 +00:17:38,500 --> 00:17:44,820 +وهي نفس الحكاية كيف عملوه قالوا شغلوا اللي هو + +216 +00:17:44,820 --> 00:17:47,980 +الانزيم هذا اللي هو عبارة عن hypoxanthine guanine + +217 +00:17:47,980 --> 00:17:51,460 +phosphoribosyl transferase enzyme ايه و it's + +218 +00:17:51,460 --> 00:17:55,580 +negative myeloma cell مشهور منها مين هذا الانزيم + +219 +00:17:55,580 --> 00:17:59,500 +اللي هو hypoxanthine guanine phosphoribosyl + +220 +00:17:59,500 --> 00:18:05,760 +transferase enzyme نيجاتيف يعني ايش مشهور منها و + +221 +00:18:05,760 --> 00:18:15,080 +بنجيب طبعا الـ B lymphocyte هذه و بنعمل fusion نحصل + +222 +00:18:15,080 --> 00:18:19,380 +على hybridoma cell ماشي هي الـ viable طبعا احنا + +223 +00:18:19,380 --> 00:18:23,960 +حصلنا على تلات خلايا خلايا الـ myeloma cell ما صلحلها + +224 +00:18:23,960 --> 00:18:30,030 +في fusion و B lymphocyte ما صلحلها في fusion وهيبردومة + +225 +00:18:30,030 --> 00:18:34,710 +cell صار لها fusion ماشي لو حتى لو ان فيها media + +226 +00:18:34,710 --> 00:18:39,850 +طبعا ما تنمو و تستمر في النمو و الـ hybrid + +227 +00:19:02,220 --> 00:19:08,060 +خطوات الـ practical steps نعمل immunization ل + +228 +00:19:08,060 --> 00:19:13,130 +animal بعد أسبوعين نعمل isolation للـ spleen cell + +229 +00:19:13,130 --> 00:19:17,490 +وهذه تحتوي على antibody producing B lymphocyte ثم + +230 +00:19:17,490 --> 00:19:21,630 +نعمل fusion للـ spleen cell مع myeloma cell وطبعا + +231 +00:19:21,630 --> 00:19:25,830 +ما يساعد على عملية الـ fusion استخدامنا للـ PEG اللي + +232 +00:19:25,830 --> 00:19:31,610 +هو polyethylene glycol substance أو material اللي + +233 +00:19:31,610 --> 00:19:35,650 +بيعمل fusion بيساعد على fusion طبعا allow unfused + +234 +00:19:35,650 --> 00:19:37,630 +B lymphocyte to die استنى عليها + +235 +00:19:44,960 --> 00:19:48,880 +عشان تقتل من الـ myeloma cell اللي برضه ما بتقدر تعيش + +236 +00:19:48,880 --> 00:19:53,800 +في هذا الـ media بيضل من الـ hybrid clone remaining + +237 +00:19:53,800 --> 00:19:58,720 +cell تاخدها و تعملها cloning تاخد one cell في كل + +238 +00:19:58,720 --> 00:20:06,670 +well من الـ 96 wells وسيبهم ت grow into a clone of + +239 +00:20:06,670 --> 00:20:12,150 +cells تاخد الـ supernatant و تعمله screening و تشوف + +240 +00:20:12,150 --> 00:20:16,930 +في الـ antibody اللي أنت بتدور عليه أنتج ولا لم + +241 +00:20:16,930 --> 00:20:23,670 +ينتج وطبعا إذا كان أنتج ابدا تنمي هذه الخلايا + +242 +00:20:25,390 --> 00:20:30,050 +culture indefinitely by subculture continuous + +243 +00:20:30,050 --> 00:20:35,230 +subculturing طبعا وكل مرة أعملها harvesting للـ + +244 +00:20:35,230 --> 00:20:39,630 +antibody من الـ supernatant تبع الـ culture وطبعا + +245 +00:20:39,630 --> 00:20:46,410 +بيقولوا أن كل one milligram بيساوي من ألف لألفين + +246 +00:20:46,410 --> 00:20:53,810 +دولار هي الطريقة هي عبارة عن myeloma cell شلنا + +247 +00:20:53,810 --> 00:20:58,320 +منها الـ hypoxanthine ما بتقدرش تنتج immunoglobulin and + +248 +00:20:58,320 --> 00:21:03,920 +immortal وهي أنتج انحققناها في الفأر خدنا الـ B + +249 +00:21:03,920 --> 00:21:08,120 +lymphocyte بسموها primed شو يعني primed يعني موجّهة + +250 +00:21:08,120 --> 00:21:14,340 +لإنتاج antibody معين primed عشان يعني الـ hypoxanthine + +251 +00:21:14,340 --> 00:21:20,180 +موجود enzyme تستطيع تنتج antibody and mortal + +252 +00:21:20,180 --> 00:21:24,380 +mortal يعني حتموت بعد فترة بنحط الـ polyethylene + +253 +00:21:24,380 --> 00:21:28,540 +glycol عشان نساعد على fusion هنحصل على تلات أنواع + +254 +00:21:28,540 --> 00:21:33,160 +من الخلايا هي الـ hybrid cell line وهي unfused + +255 +00:21:33,160 --> 00:21:37,320 +myeloma و unfused main B lymphocyte طبعا unfused B + +256 +00:21:37,320 --> 00:21:41,200 +lymphocyte هتموت وبعد هيك بنحط اللي هو الـ HAT + +257 +00:21:41,200 --> 00:21:45,980 +selection media الـ myeloma هتموت وهيظل من الـ + +258 +00:21:45,980 --> 00:21:51,950 +hybrid اللي عملها cloning ما هي الـ culturing و الـ + +259 +00:21:51,950 --> 00:21:56,890 +sub-culturing بتام دي طريقة أخرى من طرق الـ + +260 +00:21:56,890 --> 00:22:03,450 +incubation أو عملية الحقن + +261 +00:22:03,450 --> 00:22:11,470 +لها دي للفار في الـ plural cavity فبيصير فيه إنتاج + +262 +00:22:11,470 --> 00:22:15,850 + لكميات كبيرة من الـ hybrid cell وبالتالي antibody + +263 +00:22:15,850 --> 00:22:22,610 +producing cell طبعا هذا cultivation in vitro وهي + +264 +00:22:22,610 --> 00:22:27,230 +جدول بيبين الفروقات ما بين الـ polyclonal antibody + +265 +00:22:27,230 --> 00:22:31,290 +والـ monoclonal antibody هذه الـ polyclonal اللي + +266 +00:22:31,290 --> 00:22:37,490 +بتنتجها many B cell clones بينما الـ monoclonal + +267 +00:22:37,490 --> 00:22:42,950 +single B cell clone الارتباط هذا الـ polyclonal + +268 +00:22:42,950 --> 00:22:48,210 +اللي ارتبط بالـ multiple epitopes على الـ antigen + +269 +00:22:49,690 --> 00:22:53,630 +بينما الـ Monoclonal Single Epitopes Antibody + +270 +00:22:53,630 --> 00:22:57,730 +Class هنا Mixer of Classes And One Single Class + +271 +00:22:57,730 --> 00:23:02,670 +Antibody Binding Site هنا Mixer of Antibody With + +272 +00:23:02,670 --> 00:23:06,730 +Different Antigen Binding Sites بينما في الـ + +273 +00:23:06,730 --> 00:23:11,330 +Monoclonal كلهم اللي هم نفس الـ Antigen Binding + +274 +00:23:11,330 --> 00:23:16,150 +Sites الـ potential for cross reactivity طبيعي في + +275 +00:23:16,150 --> 00:23:20,330 +الـ Polyclonal في cross reactivity عالية جدا ومدينة + +276 +00:23:20,330 --> 00:23:25,790 +false positive results بينما في الـ monoclonal الـ + +277 +00:23:25,790 --> 00:23:32,570 +cross reactivity is low or even absent طيب ما هي + +278 +00:23:32,570 --> 00:23:36,750 +استخدامات الـ monoclonal antibody جالون من لو حد ما + +279 +00:23:36,750 --> 00:23:40,170 +جاريك protein and drug level in serum وطبعا كل + +280 +00:23:40,170 --> 00:23:43,470 +الاختبارات اللي بنشوفها في المعامل هي عبارة عن + +281 +00:23:43,470 --> 00:23:46,910 +antibody specific for antigen + +282 +00:23:53,380 --> 00:24:00,040 +نمر اثنين is typing tissue احنا بنعرف الـantigen اللي + +283 +00:24:00,040 --> 00:24:05,720 +على سطح نوعه اللي على سطح الخلايا by using certain + +284 +00:24:05,720 --> 00:24:08,800 +أو specific molecular antibody نمر اثنين is + +285 +00:24:08,800 --> 00:24:13,130 +identifying effectuous agents طبيعي 4 Identifying + +286 +00:24:13,130 --> 00:24:15,790 +clusters of differentiation كمان بنعمل + +287 +00:24:15,790 --> 00:24:21,730 +immunophenotyping للخلايا و بنعرف اللي هو types of + +288 +00:24:21,730 --> 00:24:27,090 +lymphoma or leukemia Identifying tumor metastases + +289 +00:24:27,090 --> 00:24:30,850 +وهذا بيستخدموه في الـdiagnostic technique طبعا كيف + +290 +00:24:30,850 --> 00:24:35,950 +بيعرفوا الـmetastases من خلال حقن الـmonoclonal + +291 +00:24:35,950 --> 00:24:39,820 +antibody و بربط فيـه radio labelled material + +292 +00:24:39,820 --> 00:24:43,660 +فبالتالي الـantibody اللي حقنها specific for the + +293 +00:24:43,660 --> 00:24:47,920 +tumor فهيظل يمشي لغاية ما يوصل هناك بيجتمع و + +294 +00:24:47,920 --> 00:24:52,560 +بعد ايش الـradio labelled material can emit lights + +295 +00:24:52,560 --> 00:24:56,420 +وبالتالي يوم ما نيجي نعمل صورة و نوجه الـ + +296 +00:24:56,420 --> 00:25:06,080 +antibody هيعمل ايش image اللي هو light و هيبين إذا + +297 +00:25:06,080 --> 00:25:10,590 +كان في tumor identifying and qualifying hormone + +298 +00:25:10,590 --> 00:25:14,790 +طبعا ممكن نبحث هرمونات فيها immuno affinity + +299 +00:25:14,790 --> 00:25:18,210 +purification كمان ممكن نستفيد من عملية + +300 +00:25:18,210 --> 00:25:24,350 +purification of antibody mixtures زي ما انتم + +301 +00:25:24,350 --> 00:25:28,730 +شايفين طبعا هذا الـmv2 احنا ممكن نحكي بالاضافة الـ + +302 +00:25:28,730 --> 00:25:34,840 +pathologist ممكن يستخدم عينة يجيب عينة بيوبسي و + +303 +00:25:34,840 --> 00:25:39,120 +يشوف طبعا يضيف عليها monoclonal antibody مع صبغة + +304 +00:25:39,120 --> 00:25:45,980 +معينة بتدي لون معين موجود اللي هو tumor وين مكانه هذا + +305 +00:25:45,980 --> 00:25:49,560 +طبعا in vitro in vivo sorry احنا ممكن نحقن انه + +306 +00:25:49,560 --> 00:25:54,120 +monoclonal antibody وطبعا زي ما قلت لكم radiolabeled + +307 +00:25:54,120 --> 00:25:58,040 +material مربوط بـ radiolabeled ونحقن هيظل يمشي + +308 +00:25:58,040 --> 00:26:01,500 +specific to the tumor وإن في tumor بالضبط في عنده + +309 +00:26:01,970 --> 00:26:06,330 +وهي شعبة فبيستخدم في الـAzadigostic Technique + +310 +00:26:06,330 --> 00:26:09,710 +أيضا في الـAffinity Chromatography زي ما انتم + +311 +00:26:09,710 --> 00:26:15,070 +شايفين فشوفنا قبل هيك نعمل مكسير في الـantigen هي + +312 +00:26:15,070 --> 00:26:19,270 +Activated Sepharose + +313 +00:26:19,270 --> 00:26:24,070 +يعني عبارة عن بيوتز بنحط عليها Antibody Monoclonal + +314 +00:26:24,070 --> 00:26:29,680 +Antibodyطبعا هي كما تشوفون الـaffinity عالية لأنها + +315 +00:26:29,680 --> 00:26:34,240 +لها أكثر من الـantibody مربوط بنحطه في mixture of + +316 +00:26:34,240 --> 00:26:39,520 +antigen هيضبط بالـantigen طبعا mix of antigen يعني + +317 +00:26:39,520 --> 00:26:41,860 +فيه أكثر من antigen لكن الـantibody حاجبة في الـ + +318 +00:26:41,860 --> 00:26:45,920 +antigen which is specific to that ناخده و بعدين + +319 +00:26:45,920 --> 00:26:48,940 +بنعمل elution فبنعمل purification لـ الـantigen + +320 +00:26:48,940 --> 00:26:53,360 +purification لـ الـantigen طبعا هذا الكلام ممكن + +321 +00:26:53,360 --> 00:26:57,080 +نعمله using chromatography + +322 +00:26:58,210 --> 00:27:02,790 +طبعا هي و بعد هيك هي beads مرتبط فيها antibody + +323 +00:27:02,790 --> 00:27:06,410 +مرتبط في الـantigen اللي احنا بدنا اياه بعد هيك ده + +324 +00:27:06,410 --> 00:27:08,070 +هو و بعد هيك ده هو و بعد هيك ده هو و بعد هيك ده هو + +325 +00:27:08,070 --> 00:27:08,190 +بعد هيك ده هو و بعد هيك ده هو و بعد هيك ده هو و + +326 +00:27:08,190 --> 00:27:08,370 +بعد هيك ده هو و بعد هيك ده هو و بعد هيك ده هو و + +327 +00:27:08,370 --> 00:27:15,270 +بعد هيك ده هو و بعد هيك ده هو و بعد هيك ده هو و + +328 +00:27:15,270 --> 00:27:21,690 +بعد هيك ده هو و بعد هيك ده هو و + +329 +00:27:28,910 --> 00:27:35,990 +طبعا الـ..think that these antibodies have + +330 +00:27:35,990 --> 00:27:40,290 +promising agents promising future for human + +331 +00:27:40,290 --> 00:27:45,090 +therapy يعني بيفكروا في انهم يكونوا دور أساسي في + +332 +00:27:45,090 --> 00:27:49,730 +عملية علاج كثير من الأمراض و منها الـcancer و منها + +333 +00:27:49,730 --> 00:27:54,410 +الـcancer فبيفكروا انهم يستخدموا الـunmonocular + +334 +00:27:54,410 --> 00:27:58,330 +antibody في موضوع بيسموه targeting therapy ايش + +335 +00:27:58,330 --> 00:28:01,780 +يعني targeting therapy يعني بس الـantibody which is + +336 +00:28:01,780 --> 00:28:06,740 +specific for certain tumor ممكن نربط فيه dialogue + +337 +00:28:06,740 --> 00:28:13,720 +chemotherapy و الـchemotherapy هذا يمشي لغاية ما + +338 +00:28:13,720 --> 00:28:17,320 +يصل الـtumor و عند الـtumor فقط يقتل الـtumor cell + +339 +00:28:17,320 --> 00:28:21,720 +سموه targeting therapy لكن للأسف لغاية الآن + +340 +00:28:21,720 --> 00:28:26,240 +الـantigenicity of antibody still a problem + +341 +00:28:30,240 --> 00:28:36,240 +المشكلة انهم بيفكروا انهم بيعملوا monoclonal antibody + +342 +00:28:36,240 --> 00:28:41,340 +وزي ما قلنا لكم ان هذا الـantigen الذي تبعته عالي + +343 +00:28:41,340 --> 00:28:45,840 +يوم ما نحكي انه فيه human هيكون جسم الإنسان + +344 +00:28:45,840 --> 00:28:49,200 +هيعتبره antigen وبالتالي يكون له antibody وبالتالي + +345 +00:28:49,200 --> 00:28:54,330 +فيه rejection لهذا الموضوع فاليوم بيفكروا يعملوا in + +346 +00:28:54,330 --> 00:28:59,050 +genetically engineered antibody to replace the + +347 +00:28:59,050 --> 00:29:05,730 +mouse monoclonal antibody واليوم + +348 +00:29:05,730 --> 00:29:10,730 +بيفكروا كمان with counter انهم يذاكروا هذا الـ + +349 +00:29:10,730 --> 00:29:15,450 +antibody يعني ما يحكوش كل الـantibody وانما + +350 +00:29:15,450 --> 00:29:20,750 +يحكوا فقط المناطق اللي هي الـhyper variable region + +351 +00:29:23,000 --> 00:29:29,580 +الذي يتعامل بالـAntigen Binding اليوم بدوا يفكروا + +352 +00:29:29,580 --> 00:29:35,340 +بانهم بيستخدموا human بدلا من mouse antibody كما + +353 +00:29:35,340 --> 00:29:42,080 +تشاهدون chimeric antibody هو الـmouse + +354 +00:29:44,080 --> 00:29:49,280 +ماشي كيف قالوا احنا بدنا نحقن نجيب antibody بطريقة + +355 +00:29:49,280 --> 00:29:53,320 +وقفة نجيب human antibody و فقط ناخذ الـFab region + +356 +00:29:53,320 --> 00:29:58,100 +اللي فيها الـhypervariable و الـFc region من الـmouse و + +357 +00:29:58,100 --> 00:30:04,040 +نركبها genetically by genetic engineering على سطح + +358 +00:30:04,040 --> 00:30:08,800 +هذا الـantibody فهو يصير عندي antibody ماشي الـ + +359 +00:30:08,800 --> 00:30:13,120 +frame تبعه كله human frame لكن ليهش الـFab تبعته من + +360 +00:30:13,120 --> 00:30:17,760 +الـmouse طبعا + +361 +00:30:17,760 --> 00:30:21,340 +عشان يقلل الـimmunogenicity كمان antibody of + +362 +00:30:21,340 --> 00:30:24,220 +single specificity يعني monoclonal كان بي obtained + +363 +00:30:24,220 --> 00:30:29,840 +by cloning الـappropriated heavy enlightened gene + +364 +00:30:29,840 --> 00:30:35,840 +وبالتالي in a vector وبالتالي هذه تقنية أخذناها طبعا + +365 +00:30:35,840 --> 00:30:39,690 +في molecular biology وبالتالي أنا ممكن أحصل على + +366 +00:30:39,690 --> 00:30:44,150 +antibody engineered Genetically engineered + +367 +00:30:44,150 --> 00:30:48,970 +antibody طبعا هذا هو الـantibody نقل الـantibody + +368 +00:30:48,970 --> 00:30:57,570 +ربطنا فيـه toxin which is specific to certain + +369 +00:30:57,570 --> 00:31:03,030 +bacteria, tumor whatever طبعا هذا بيسموه + +370 +00:31:03,030 --> 00:31:11,210 +immunotoxin وبهيك نقوم انهينا المحاضرة أتمنى عليكم + +371 +00:31:11,210 --> 00:31:15,830 +انه إن شاء الله تكونوا قد استمتعتم بها diff --git a/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/5smAuOfTr-M_postprocess.srt b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/5smAuOfTr-M_postprocess.srt new file mode 100644 index 0000000000000000000000000000000000000000..ef7f712e700552eaef4a016a2d70274a3f7f9227 --- /dev/null +++ b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/5smAuOfTr-M_postprocess.srt @@ -0,0 +1,1484 @@ +1 +00:00:05,800 --> 00:00:12,120 +السلام عليكم و رحمة الله و بركاته اليوم + +2 +00:00:12,120 --> 00:00:14,440 +ان شاء الله محاضرتنا على الـ Hybrid-OMA Technique + +3 +00:00:18,150 --> 00:00:27,010 +و موضوع بدأ ينحك فيه في ال 1975 لما بدأتوا اعلاني + +4 +00:00:27,010 --> 00:00:32,870 +اتنين two scientist كوهلر و مايلدستاين بدوا يعملوا + +5 +00:00:32,870 --> 00:00:37,770 +fusion في ال lymphocytes يعني يدمجوا lymphocyte مع + +6 +00:00:37,770 --> 00:00:42,030 +بعضها طبعا ماحصلت هذا الكلام production of cell + +7 +00:00:42,030 --> 00:00:49,130 +lineمن خصائصه انه immortal بمعنى انه يبقى موجود + +8 +00:00:49,130 --> 00:00:54,710 +دائما و ينتج انتباد محدث انتباد محدث انتباد محدث + +9 +00:00:54,710 --> 00:00:56,370 +انتباد محدث انتباد محدث انتباد محدث انتباد محدث + +10 +00:00:56,370 --> 00:00:56,470 +انتباد محدث انتباد محدث انتباد محدث انتباد محدث + +11 +00:00:56,470 --> 00:00:58,170 +انتباد محدث انتباد محدث انتباد محدث انتباد محدث + +12 +00:00:58,170 --> 00:00:58,210 +انتباد محدث انتباد محدث انتباد محدث انتباد محدث + +13 +00:00:58,210 --> 00:00:59,010 +انتباد محدث انتباد محدث انتباد محدث انتباد محدث + +14 +00:00:59,010 --> 00:01:03,370 +انتباد محدث انتباد محدث انتباد محدث انتباد + +15 +00:01:03,370 --> 00:01:10,610 +محدث انتباد + +16 +00:01:10,610 --> 00:01:15,830 +ملكنه لم يستغل هذا التقنيك لغاية 1987 يوم ما بدوا + +17 +00:01:15,830 --> 00:01:20,590 +يفكروا يستخدموا ال monoclonal antibody in + +18 +00:01:20,590 --> 00:01:28,930 +diagnostic techniques in + +19 +00:01:28,930 --> 00:01:34,490 +a specific immune response اول ما هي طبعا خلايا + +20 +00:01:34,490 --> 00:01:37,870 +اللي قالتلي تتنشط عند دخول ال antigen هي عبارة عن + +21 +00:01:37,870 --> 00:01:42,880 +كوكتيل من ال B و T lymphocytesوطبعا ال figure واضح + +22 +00:01:42,880 --> 00:01:50,680 +جدا ان هناك كوكتيل من ال B وT الانفوسايت يتصدى + +23 +00:01:50,680 --> 00:01:54,300 +الانتجين هذا الانتجين من صفاته انه يحتوي على ازرق + +24 +00:01:54,300 --> 00:01:58,120 +واحد و أحمر اثناء الانتجين وبالتالي الخلايا التي + +25 +00:01:58,120 --> 00:02:02,400 +تصدت لهذا الانفوسايت هي الخلايا الزرقاء والحمراء + +26 +00:02:02,400 --> 00:02:07,900 +التي تحتوي على مصادر محددة للانفوسايتوصار حاجة + +27 +00:02:07,900 --> 00:02:12,660 +بيسميناها في السابق Clonal Selection ل هذه الخلايا + +28 +00:02:12,660 --> 00:02:18,600 +اللي بعد هي كصار في Clonal Expansion فهذه زي ما + +29 +00:02:18,600 --> 00:02:22,320 +انتوا شايفين الخلايا الزرقى والخلايا الحمرا صار + +30 +00:02:22,320 --> 00:02:27,500 +لها Clonal Expansion after selection صار في + +31 +00:02:27,500 --> 00:02:31,640 +expansion وصار في اني many many cells which have + +32 +00:02:31,640 --> 00:02:36,460 +the same specificity for the two epitopes involved + +33 +00:02:39,120 --> 00:02:42,560 +المحصلة في هذه الحالة هو إنتاج Polyclonal Antibody + +34 +00:02:42,560 --> 00:02:47,620 +لأنه صار في عندي أكتر من Epitopes للـ Antigen تصدت + +35 +00:02:47,620 --> 00:02:52,060 +إليه أكتر من خلية وكل خلية طلعت لنا Antibody for + +36 +00:02:52,060 --> 00:02:54,920 +specific Epitope فصار كوكتيل من ال Epitopes + +37 +00:02:54,920 --> 00:03:01,520 +موجودين فالمحصلة إنتاج Polyclonal Antibody عشان هي + +38 +00:03:01,520 --> 00:03:05,920 +كذا يوم ما يصير فيه immunization لأى animal with a + +39 +00:03:05,920 --> 00:03:12,680 +proteinعدد كبير من الـ B-lymphocyte سيكون مدفع على + +40 +00:03:12,680 --> 00:03:17,820 +الانتبروتين انتبوتين انتبوتين انتبوتين انتبوتين + +41 +00:03:17,820 --> 00:03:19,560 +انتبوتين انتبوتين انتبوتين انتبوتين انتبوتين + +42 +00:03:19,560 --> 00:03:22,220 +انتبوتين انتبوتين انتبوتين انتبوتين انتبوتين + +43 +00:03:22,220 --> 00:03:31,120 +انتبوتين انتبوتين انتبوتين انتبوتين انتبوتين + +44 +00:03:31,120 --> 00:03:33,800 +انتبوتين انتبوتين انتبوتين انتبوتين انتبوتين + +45 +00:03:33,800 --> 00:03:34,200 +انتبوتين انتبوتين انتبوتين انتبوتين انتبوتين + +46 +00:03:34,200 --> 00:03:35,580 +انتبوتين انتبوتين انتبوتين انتبوتين انتبmay have + +47 +00:03:35,580 --> 00:03:41,500 +different antigen binding sites بمعنى آخر they may + +48 +00:03:41,500 --> 00:03:47,310 +have different affinity to the same epitopeالمحصلة + +49 +00:03:47,310 --> 00:03:51,950 +انه في mixture of antibody produced in response to + +50 +00:03:51,950 --> 00:03:55,790 +that antigen and this these antibodies are called + +51 +00:03:55,790 --> 00:03:59,650 +polyclonal antibody they produced by many + +52 +00:03:59,650 --> 00:04:03,570 +different clones of B lymphocytes طبيعي جدا تهيأ + +53 +00:04:03,570 --> 00:04:07,510 +اليوم ادخل ال antigen وزي ما انتوا شايفين فيه اكتر + +54 +00:04:07,510 --> 00:04:12,050 +من Epitopes لان كل لون بيمثل Epitopes + +55 +00:04:15,100 --> 00:04:21,680 +صح هذا هي ال Epitopes مختلفة عملنا له immunization + +56 +00:04:21,680 --> 00:04:27,960 +ل animal صار فى immune response و المحصلة + +57 +00:04:27,960 --> 00:04:33,600 +different B cell have been stimulatedوكل واحدة + +58 +00:04:33,600 --> 00:04:38,840 +طلعت Antibody specific for certain Epitopes + +59 +00:04:38,840 --> 00:04:46,360 +والمحصلة كوكتيل من ال Antibodies سمناهم Polyclonal + +60 +00:04:46,360 --> 00:04:52,340 +Antibody يعني a mixture of Antibody وكلهم برتبته + +61 +00:04:52,340 --> 00:04:57,520 +بال Epitopes of the original protein or antigen + +62 +00:04:58,910 --> 00:05:05,150 +طبعا في منهم يرتبط بقوة اكتر من التاني يعني ال + +63 +00:05:05,150 --> 00:05:09,190 +affinity to off binding is different these are + +64 +00:05:09,190 --> 00:05:13,050 +called مرة تانية polyclonal antibody يبقى ال + +65 +00:05:13,050 --> 00:05:16,270 +polyclonal antibody are a mixture of antibody with + +66 +00:05:16,270 --> 00:05:19,130 +different antigen binding sites and may have + +67 +00:05:19,130 --> 00:05:23,610 +different may bind to different epitopes of + +68 +00:05:23,610 --> 00:05:30,370 +antigen وين يوم ما يدخللما نعمل immunization for + +69 +00:05:30,370 --> 00:05:37,190 +certain animal فبتكون هناك antibody for immunizing + +70 +00:05:37,190 --> 00:05:42,590 +agents they have varying affinity and they may + +71 +00:05:42,590 --> 00:05:47,300 +have different classes of antibodyالسيرام اللي + +72 +00:05:47,300 --> 00:05:51,680 +اكتشفته ايضا بيسموه polyclonal antiserum ال + +73 +00:05:51,680 --> 00:05:55,000 +polyclonal antiserum بيحتوي على انتيبودي + +74 +00:05:55,000 --> 00:05:59,480 +لإيبيتوبات مختلفة وانتجين مختلفة تحتوي على انتجين + +75 +00:05:59,480 --> 00:06:00,840 +مختلفة تحتوي على انتجين مختلفة تحتوي على انتجين + +76 +00:06:00,840 --> 00:06:01,780 +مختلفة تحتوي على انتجين مختلفة تحتوي على انتجين + +77 +00:06:01,780 --> 00:06:01,860 +مختلفة تحتوي على انتجين مختلفة تحتوي على انتجين + +78 +00:06:01,860 --> 00:06:02,220 +مختلفة تحتوي على انتجين مختلفة تحتوي على انتجين + +79 +00:06:02,220 --> 00:06:09,500 +مختلفة تحتوي على انتجين مختلفة تحتوي على انتجين + +80 +00:06:09,500 --> 00:06:15,910 +مختلفة تحتوي علىكيف بيصير عملية ال purification زي + +81 +00:06:15,910 --> 00:06:19,410 +ما اتخذته في column chromatography ده هو ندخل + +82 +00:06:19,410 --> 00:06:25,590 +beats عليها antigen specific to certain antibody + +83 +00:06:25,590 --> 00:06:28,750 +من انه انتبادى من الانتبادى اللى موجودة فى ال + +84 +00:06:28,750 --> 00:06:32,570 +mixture اللى بده اعمله purification فطبعا بعد هيك + +85 +00:06:32,570 --> 00:06:37,050 +بنعمل purification لل mixture بيدخل على ال beats + +86 +00:06:37,860 --> 00:06:41,980 +بيرتبط ال antibody اللى بديها which is specific + +87 +00:06:41,980 --> 00:06:48,380 +for the antigen اللى موجود على ال beats و الباقى + +88 +00:06:48,380 --> 00:06:53,560 +بنزل الباقى ال antibody بنزل اللى لبروتينات ال + +89 +00:06:53,560 --> 00:06:58,060 +antibody اللى ليس لها it's not specific for that + +90 +00:06:58,060 --> 00:07:02,180 +antigen يبقى احنا في هذه العملية مسكنا one + +91 +00:07:02,180 --> 00:07:07,810 +antibody من mixture of antibodies والباقى نزلبعد + +92 +00:07:07,810 --> 00:07:08,890 +ذلك بناخد ال beats + +93 +00:07:21,740 --> 00:07:31,280 +طبعا illusion in certain اللي هو mixture + +94 +00:07:31,280 --> 00:07:36,340 +أيوة antigen can be bound to the support matrix in + +95 +00:07:36,340 --> 00:07:39,800 +order to purify antigen specific antibody from + +96 +00:07:39,800 --> 00:07:43,940 +polyclonal antiserum طبعا هذه العملية ممكن تتكرر ب + +97 +00:07:43,940 --> 00:07:47,480 +antigen تانيspecific for antibody برضه في ال + +98 +00:07:47,480 --> 00:07:50,740 +mixture و شوية شوية بنعمل عملية verification لل + +99 +00:07:50,740 --> 00:07:55,560 +antibody واحد ولا التاني هي عندي different B cell + +100 +00:07:55,560 --> 00:07:59,920 +عندها القدرة انها تطلعلي different antibody و + +101 +00:07:59,920 --> 00:08:05,720 +محصلة mixture of antibody طبعا هي احنا ممكن ناخد + +102 +00:08:05,720 --> 00:08:12,790 +one cell تطلعلي one specific antibodyطبعا هذا + +103 +00:08:12,790 --> 00:08:20,430 +الخلية ممكن نعملها culturing و تطلعلي many many + +104 +00:08:20,430 --> 00:08:24,970 +antibody specific to that antigen بعدين بنعمل + +105 +00:08:24,970 --> 00:08:30,600 +harvesting ل ال antibody اللي طلعو في هذه الحالة + +106 +00:08:30,600 --> 00:08:35,460 +لما باخد خلية بتطلع antibody واحد حصلها monoclonal + +107 +00:08:35,460 --> 00:08:38,080 +antibody بس في مشكلة فيها ده ده مش hybridoma + +108 +00:08:38,080 --> 00:08:41,280 +technica ده عبارة عن خلية أخدناها و زرعناها أو + +109 +00:08:41,280 --> 00:08:44,540 +عملنا لها culturing و طلعتناها antibody طبعا بعد + +110 +00:08:44,540 --> 00:08:48,990 +ما هيجناها ب antibodyهذه طبعا طريقة أخرى من طريقة + +111 +00:08:48,990 --> 00:08:53,450 +الفصل انه احنا ناخد فينا different cell طلعت ليه + +112 +00:08:53,450 --> 00:08:56,310 +different antibody طلع عندي mixture of antibody + +113 +00:08:56,310 --> 00:09:00,670 +اخدنا خلية واحدة منها culturing وبتطلعنا ايش + +114 +00:09:00,670 --> 00:09:05,570 +antibody واحد اللي ممكن انه هلاقاش مشكلة في هذه + +115 +00:09:05,570 --> 00:09:09,630 +القضية ان هذه الخلية لها lifespan محدد وبالتالي + +116 +00:09:09,630 --> 00:09:15,150 +هتموت بعد فترةلكن انا معنى باني احصل على خلية + +117 +00:09:15,150 --> 00:09:20,230 +which is immortal هذا الكلام بيتحقق يوم اعمل + +118 +00:09:20,230 --> 00:09:25,490 +hybridoma تقنية ال hybridomas كيف بتصير قالوا + +119 +00:09:25,490 --> 00:09:30,750 +بيليمفوسايت can mutate into tumor cell انا ممكن + +120 +00:09:30,750 --> 00:09:34,250 +اجيب بيليمفوسايت و اعملها mutation وبالتالي تتحول + +121 +00:09:34,250 --> 00:09:39,830 +ل tumor cell و طبعا في هذه الحالة بيسموها myeloma + +122 +00:09:39,830 --> 00:09:45,030 +cellوهو عبارة عن cancer of B lymphocytes او plasma + +123 +00:09:45,030 --> 00:09:50,350 +cell الملومة cell في هذه الحالة become immortal + +124 +00:09:50,350 --> 00:09:53,930 +لأنها صارت tumor و ال tumor is resistant to + +125 +00:09:53,930 --> 00:09:58,150 +apoptosis وبالتالي can grow indefinitely in + +126 +00:09:58,150 --> 00:10:04,050 +culture media طب شو بتعمل في هذه الحالةعشان اعمل + +127 +00:10:04,050 --> 00:10:07,690 +hybrid هما قالوا بنعمل fusion of a single + +128 +00:10:07,690 --> 00:10:11,930 +activated خلاية + +129 +00:10:11,930 --> 00:10:20,830 +محفظة لإنتاج certain antibody بجيب + +130 +00:10:20,830 --> 00:10:25,630 +هذه الخلية اللي عبارة عن activated B cellوبعمل + +131 +00:10:25,630 --> 00:10:30,130 +fusion لهذه الخلية مع myeloma cell اللي انا عملتها + +132 +00:10:30,130 --> 00:10:35,270 +وبالتالي بعمل hybridoma وهو عبارة عن بحصل على خلية + +133 +00:10:35,270 --> 00:10:38,970 +مهجنة that can grow indefinitely in culture media + +134 +00:10:38,970 --> 00:10:44,110 +هذه الخلية بي lymphocytes which can secrete + +135 +00:10:44,110 --> 00:10:46,550 +antibody but do not grow in different tissue + +136 +00:10:46,550 --> 00:10:52,920 +culture وبجيب myeloma cellوهي زمان كما تشايفين + +137 +00:10:52,920 --> 00:10:58,140 +myeloma cell can grow indefinitely in cell culture + +138 +00:10:58,140 --> 00:11:02,360 +but do not secrete the desired antibody اللي فوق + +139 +00:11:02,360 --> 00:11:07,080 +بتطلعلي antibody ها دي mutated and cannot secrete + +140 +00:11:07,080 --> 00:11:13,160 +antibody بعملي fusion بين التنتين هي fusion ثم + +141 +00:11:13,160 --> 00:11:18,540 +بحصل على hybrid oma cellلي عبارة عن خلية هاجين ما + +142 +00:11:18,540 --> 00:11:23,940 +بين البيسل والميلوماسل وهذه الخلية can grow + +143 +00:11:23,940 --> 00:11:28,720 +indefinitely in culture media and can secrete + +144 +00:11:28,720 --> 00:11:33,480 +antibody وهي المحصلة والله باخد هذه الخلية و + +145 +00:11:33,480 --> 00:11:37,660 +بعملها sub-culturing وبالتالي هذه الخلية can grow + +146 +00:11:37,660 --> 00:11:42,360 +indefinitely و بتطلع لي in the same time + +147 +00:11:49,730 --> 00:11:55,170 +الخلية ال بيليمفوسايت اللى احنا حفظناها او قدمنا + +148 +00:11:55,170 --> 00:12:00,070 +لها انتيجن فى البداية فهتكون انتيبادي يبقى + +149 +00:12:00,070 --> 00:12:04,510 +الانتيبادي بيطلع specific for only specific + +150 +00:12:04,510 --> 00:12:08,110 +antigen and this is called monoclonal antibody + +151 +00:12:11,610 --> 00:12:14,190 +يبقى الـ Monoclonal Antibody يبقى ان الانتبادي + +152 +00:12:14,190 --> 00:12:20,530 +ينتج من احدة كلون من بيليمفوسايز وحصلنا عليه من + +153 +00:12:20,530 --> 00:12:24,510 +خلال ال fusion of B cell which secretes the + +154 +00:12:24,510 --> 00:12:29,170 +desired antibody مع myeloma cell which is capable + +155 +00:12:29,170 --> 00:12:33,070 +of growing indefinitely in tissue culture هنحصل + +156 +00:12:33,070 --> 00:12:38,590 +على Monoclonal Antibody which all have identical + +157 +00:12:38,590 --> 00:12:43,810 +antigen binding sitesو يمكنهم أيضًا أن يتعاملوا مع + +158 +00:12:43,810 --> 00:12:50,150 +نفسهم مع نفس الـ Epitope مع نفس الـ Affinity و هم + +159 +00:12:50,150 --> 00:12:55,130 +جميعًا من نفس السلفات الانتيبوديية يبقى شوفوا من + +160 +00:12:55,130 --> 00:12:58,990 +صفات الـ Monoclonal Antibody لديهم مجموعة متعاملة + +161 +00:12:58,990 --> 00:13:01,570 +عنتجينية متعاملة متعاملة متعاملة متعاملة متعاملة + +162 +00:13:01,570 --> 00:13:02,370 +متعاملة متعاملة متعاملة متعاملة متعاملة متعاملة + +163 +00:13:02,370 --> 00:13:05,290 +متعاملة متعاملة متعاملة متعاملة متعاملة متعاملة + +164 +00:13:05,290 --> 00:13:06,290 +متعاملة متعاملة متعاملة متعاملة متعاملة متعاملة + +165 +00:13:06,290 --> 00:13:09,310 +متعاملة متعاملة متعاملة متعام + +166 +00:13:10,370 --> 00:13:15,790 +كلهم with the same affinity وكل ال antibody are + +167 +00:13:15,790 --> 00:13:21,170 +done من نفس ال class طيب شوفوا ال procedure + +168 +00:13:21,170 --> 00:13:26,930 +بالتفصيل هنا جيبنا فعر وعملنا له immunization و + +169 +00:13:26,930 --> 00:13:33,790 +certain antigen طبعا بعد فترة بناخد ال spleen بعد + +170 +00:13:33,790 --> 00:13:39,630 +أسبوعين بناخد ال spleen تبع الفعر هذاوبناخد منه + +171 +00:13:39,630 --> 00:13:45,390 +الخلايا اللي هي ال B-cell وفي نفس الوقت بنحصل نجيب + +172 +00:13:45,390 --> 00:13:48,610 +tumor cell سواء احنا عملناها او جيبناها already + +173 +00:13:48,610 --> 00:13:54,290 +tumor بنتشره culture وبتنتين بعملهم fusion وبحصل + +174 +00:13:54,290 --> 00:13:57,270 +على hybridoma cell بعملها sub-culturing ده هي + +175 +00:13:57,270 --> 00:14:00,590 +hybridoma which can screened for antibody + +176 +00:14:00,590 --> 00:14:06,230 +production ومحصلها monoclonal antibodyنفس الصورة x + +177 +00:14:06,230 --> 00:14:11,670 +-antigen isolate spleen cell بعد فترة فتحصل عليها + +178 +00:14:11,670 --> 00:14:17,270 +اللي هو mixture of spleen cell بما فيهم ال anti x + +179 +00:14:17,270 --> 00:14:23,150 +-antibody cell مع نجيب mutated mutant myeloma line + +180 +00:14:23,150 --> 00:14:30,230 +unable to grow in hat media الآن هنعرفش يعني hatو + +181 +00:14:30,230 --> 00:14:33,670 +مابينتجش Antibody فبنحصل عليها طبعا تلت أنواع من + +182 +00:14:33,670 --> 00:14:37,550 +الخلايا خلايا ماصلحش Fusion وخلايا already صلها + +183 +00:14:37,550 --> 00:14:42,970 +Fusion وصلحت hybridoma وخلايا tumor cell ماصللها + +184 +00:14:42,970 --> 00:14:46,790 +Fusion تلت أنواع من الخلايا طبعا هذا الكلام مهم + +185 +00:14:46,790 --> 00:14:51,190 +بيصير في culture سموها media لإن ماعرفش ال hat + +186 +00:14:51,190 --> 00:14:56,570 +ماشي و بالتالي ال albionic acid اللي ماصل لها + +187 +00:14:56,570 --> 00:15:03,440 +Fusion هتموت بعد فترةو ال tumor cell برضه هتموت + +188 +00:15:03,440 --> 00:15:07,880 +لأنه لا تستطيع أن تنمو في وسط اللي حطناها فيه + +189 +00:15:07,880 --> 00:15:10,780 +لولها ال media فبتبقى ال hybrid هو ما هي اللي + +190 +00:15:10,780 --> 00:15:17,920 +بتبقى عايشة خلايا بتموت تلات أنواع ناخدها بعد هيك + +191 +00:15:17,920 --> 00:15:24,270 +و نعملها sub-culturing و تحصل علاج على خلايانفس + +192 +00:15:24,270 --> 00:15:28,810 +الصورة هي two cells fused antibody-screening B + +193 +00:15:28,810 --> 00:15:32,810 +lymphocyte hybridoma cell طلعت منها نفس اللي احكى + +194 +00:15:32,810 --> 00:15:43,430 +هو دي صورة لها اللي هو ال 69 well plate بنعمل فيه + +195 +00:15:43,430 --> 00:15:51,370 +culturing بنخفف اللي هو dilution معين لل hybridoma + +196 +00:15:51,370 --> 00:15:56,540 +cell line و بنحصل علىاللي هي خلايا عديدة و بنعمل + +197 +00:15:56,540 --> 00:16:04,520 +sub-culturing و طول ما هي بتنتج طبعا هي الخلايا + +198 +00:16:04,520 --> 00:16:10,260 +اللي هي في ال culture tissue culture ممكن نفحصها + +199 +00:16:10,260 --> 00:16:15,790 +by inverted microscope اللي هيخلايا عايشة ولا ميتة + +200 +00:16:15,790 --> 00:16:24,190 +وهكذا وهذه صورة لعملية تخزين لهذه الخلايا فاطفى + +201 +00:16:24,190 --> 00:16:31,090 +طبعا اللى هو incubators درجات حرارة متدنية عشان + +202 +00:16:31,090 --> 00:16:39,830 +تنحفظ طيب نجى لل hybridoma technique بتفاصيلته + +203 +00:16:41,380 --> 00:16:45,540 +أول شيء ميلوما سيل هف بين genetically engineered + +204 +00:16:45,540 --> 00:16:52,640 +ماشي لعبوا فيها genetically بحيث انه these cell + +205 +00:16:52,640 --> 00:16:58,280 +they cannot use hypoxanthine امينوبترين انثايميدين + +206 +00:16:58,280 --> 00:17:03,960 +لكل هات ميديا يعني لو حطناها في هات ميديا ما بتقدر + +207 +00:17:03,960 --> 00:17:08,020 +تنقو في هذا ال medium و هدولة نيكليوب اللي هو + +208 +00:17:08,020 --> 00:17:14,510 +نيكليوبروتين او نيكليوبروتينفيوم ما نعملها و نحطها + +209 +00:17:14,510 --> 00:17:19,710 +في ال culture يحتوي على هذه المواد لأ تستطيع ان + +210 +00:17:19,710 --> 00:17:22,670 +تمويلها لعبنا فيها genetically اخدوا منها انزايم + +211 +00:17:22,670 --> 00:17:28,130 +عندنا هنشوفه ايش هو الانزايم طيب الحاجة التانية + +212 +00:17:28,130 --> 00:17:31,800 +only be cells that have usedwith the engineered + +213 +00:17:31,800 --> 00:17:34,760 +myeloma cell will survive بقى ال hybrid myeloma + +214 +00:17:34,760 --> 00:17:38,500 +cell اللى طلعت اللى هى اللى بتستطيع انها عياش تنمو + +215 +00:17:38,500 --> 00:17:44,820 +وهى نفس الحكاية كيف عملوه لقالوا شعلوا اللى هو + +216 +00:17:44,820 --> 00:17:47,980 +الانزيم هذا اللى هو عبارة عن hypoxanthin guanine + +217 +00:17:47,980 --> 00:17:51,460 +phosphoribosyl transferase enzyme ايه و it's + +218 +00:17:51,460 --> 00:17:55,580 +negative myeloma cell مشهور منها مين هذا الانزيم + +219 +00:17:55,580 --> 00:17:59,500 +اللى هو hypoxanthin guanine phosphoribosyl + +220 +00:17:59,500 --> 00:18:05,760 +transferaseانزاين نيجاتيف يعني ايش مشهور منها و + +221 +00:18:05,760 --> 00:18:15,080 +بنجيب طبعا ال بي لينفوسايز هذه و بنعمل fusion نحصل + +222 +00:18:15,080 --> 00:18:19,380 +على hybridoma cell ماشي هي ال viable طبعا احنا + +223 +00:18:19,380 --> 00:18:23,960 +حصلنا على تلت خلايا خلايا لم myeloma cell ماصلها + +224 +00:18:23,960 --> 00:18:30,030 +في fusion وبي لينفوسايز ماصلها في fusion وهيبردومة + +225 +00:18:30,030 --> 00:18:34,710 +cell صار لها fusion ماشي لو حتى لو ان فيها media + +226 +00:18:34,710 --> 00:18:39,850 +طبعا ما ينمو و يستمر في النمو و ال hybrid + +227 +00:19:02,220 --> 00:19:08,060 +خطوات ال practical steps نعمل immunization ل + +228 +00:19:08,060 --> 00:19:13,130 +animal بعدأسبوعين نعمل isolation للـ spleen cell + +229 +00:19:13,130 --> 00:19:17,490 +وهذه تحتوي على antibody producing B lymphocyte ثم + +230 +00:19:17,490 --> 00:19:21,630 +نعمل fusion للـ spleen cell مع myeloma cell وطبعا + +231 +00:19:21,630 --> 00:19:25,830 +ما يساعد على عملية ال fusion استخدامنا لل PEG اللي + +232 +00:19:25,830 --> 00:19:31,610 +هو polyethylene glycol substance او material اللي + +233 +00:19:31,610 --> 00:19:35,650 +بيعمل fusion بيساعد على fusion طبعا allow unfused + +234 +00:19:35,650 --> 00:19:37,630 +B lymphocyte to die استنى عليها + +235 +00:19:44,960 --> 00:19:48,880 +عشان تقتل من الميلوما سيل اللي برضه مابتقدر تعيش + +236 +00:19:48,880 --> 00:19:53,800 +في هذا ال media بيضال من ال hybrid clone remaining + +237 +00:19:53,800 --> 00:19:58,720 +cell تاخدها و تعملها cloning تاخد one cell في كل + +238 +00:19:58,720 --> 00:20:06,670 +wellمن ال 96 wells و سيبهم ت grow into a clone of + +239 +00:20:06,670 --> 00:20:12,150 +cells تاخد ال supernatant و تعمله screening و تشوف + +240 +00:20:12,150 --> 00:20:16,930 +في ال antibody اللي انت بتدور عليه انتج ولا لم + +241 +00:20:16,930 --> 00:20:23,670 +ينتج و طبعا اذا كان انتج ابدا تنمي هذه الخلايا + +242 +00:20:25,390 --> 00:20:30,050 +culture indefinitely by subculture continuous + +243 +00:20:30,050 --> 00:20:35,230 +subculturing طبعا و كل مرة اعملها harvesting لل + +244 +00:20:35,230 --> 00:20:39,630 +antibody من ال supernatant تبع ال culture و طبعا + +245 +00:20:39,630 --> 00:20:46,410 +بيقولوا ان كل one milligram بيساوي من الف لألفين + +246 +00:20:46,410 --> 00:20:53,810 +دولار هي الطريقة هي عبارة عن myeloma cell شيلنا + +247 +00:20:53,810 --> 00:20:58,320 +منها الحيبوذانتينما بتقدرش تنتج immunoglobulin and + +248 +00:20:58,320 --> 00:21:03,920 +immortal وهي أنتج انحققناها في الفعر خدنا ال B + +249 +00:21:03,920 --> 00:21:08,120 +lymphocyte بسموها primed شو يعني primed يعني موجهة + +250 +00:21:08,120 --> 00:21:14,340 +لإنتاج antibody معين primed عشان يعني العيبوزنثين + +251 +00:21:14,340 --> 00:21:20,180 +موجود enzyme تستطيع تنتج antibody and mortal + +252 +00:21:20,180 --> 00:21:24,380 +mortal يعني حتموت بعد فترة بنحط ال polyethylene + +253 +00:21:24,380 --> 00:21:28,540 +glycolعشان نساعد على fusion هنحصل على تلات أنواع + +254 +00:21:28,540 --> 00:21:33,160 +من الخلايا هي ال hybrid cell line وهي unfused + +255 +00:21:33,160 --> 00:21:37,320 +myeloma و unfused main B lymphocyte طبعا unfused B + +256 +00:21:37,320 --> 00:21:41,200 +lymphocyte هتموت و بعد هيك بنحط اللي هو ال head + +257 +00:21:41,200 --> 00:21:45,980 +selection media ال myeloma هتموت و هيظلمين ال + +258 +00:21:45,980 --> 00:21:51,950 +hybrid اللي عملها cloningما هي ال culturing و ال + +259 +00:21:51,950 --> 00:21:56,890 +sub-culturing بتام دي طريقة اخرى من طرق ال + +260 +00:21:56,890 --> 00:22:03,450 +incubation او عملية الحقن + +261 +00:22:03,450 --> 00:22:11,470 +لها دي للفار في ال plural cavity فبصير فيه إنتاج + +262 +00:22:11,470 --> 00:22:15,850 +لكميات كبيرة من ال hybrid cell وبالتالي antibody + +263 +00:22:15,850 --> 00:22:22,610 +producing cellطبعا هذا cultivation in vitro وهي + +264 +00:22:22,610 --> 00:22:27,230 +جدول بيبين الفروقات ما بين ال polyclonal antibody + +265 +00:22:27,230 --> 00:22:31,290 +و ال monoclonal antibody هذه ال polyclonal اللى + +266 +00:22:31,290 --> 00:22:37,490 +بتنتجها many B cell clones بينما ال monoclonal + +267 +00:22:37,490 --> 00:22:42,950 +single B cell clone الارتباط هذا ال polyclonal + +268 +00:22:42,950 --> 00:22:48,210 +اللى ارتبط بال multiple epitopes على ال antigen + +269 +00:22:49,690 --> 00:22:53,630 +بينما الـ Monoclonal Single Epitopes Antibody + +270 +00:22:53,630 --> 00:22:57,730 +Class هنا Mixer of Classes And One Single Class + +271 +00:22:57,730 --> 00:23:02,670 +Antibody Binding Site هنا Mixer of Antibody With + +272 +00:23:02,670 --> 00:23:06,730 +Different Antigen Binding Sites بينما في الـ + +273 +00:23:06,730 --> 00:23:11,330 +Monoclonal كلهم اللي هم نفس ال Antigen Binding + +274 +00:23:11,330 --> 00:23:16,150 +Sites ال potential for cross reactivity طبيعي في + +275 +00:23:16,150 --> 00:23:20,330 +ال Polyclonal في cross reactivity عالية جداومدينة + +276 +00:23:20,330 --> 00:23:25,790 +false positive results بينما في ال monoclonal ال + +277 +00:23:25,790 --> 00:23:32,570 +cross reactivity is low or even absent طيب ما هي + +278 +00:23:32,570 --> 00:23:36,750 +استخدامات ال monoclonal antibody جالون من لو حد ما + +279 +00:23:36,750 --> 00:23:40,170 +جاريك protein and drug level in serum وطبعا كل + +280 +00:23:40,170 --> 00:23:43,470 +الكتات اللي بنشوفها في المعامل هي عبارة عن + +281 +00:23:43,470 --> 00:23:46,910 +antibody specific for antigen + +282 +00:23:53,380 --> 00:24:00,040 +نمر اتنين is typing tissue احنا بنعرف الاماثي اللى + +283 +00:24:00,040 --> 00:24:05,720 +على سطح نوعه اللى على سطح الغلايا by using certain + +284 +00:24:05,720 --> 00:24:08,800 +او specific molecular antibody نمر اتنين is + +285 +00:24:08,800 --> 00:24:13,130 +identifying effectuous agents طبيعى4 Identifying + +286 +00:24:13,130 --> 00:24:15,790 +clusters of differentiation كمان نعمل + +287 +00:24:15,790 --> 00:24:21,730 +immunophenotyping للخلايا و بنعرف اللي هو types of + +288 +00:24:21,730 --> 00:24:27,090 +lymphoma or leukemia Identifying tumor metastases + +289 +00:24:27,090 --> 00:24:30,850 +وهذا بيستخدموه في ال diagnostic technique طبعا كيف + +290 +00:24:30,850 --> 00:24:35,950 +بيعرفوا ال metastases من خلال حقن ال monoclonal + +291 +00:24:35,950 --> 00:24:39,820 +antibody و بربط في ديلوradio labelled material + +292 +00:24:39,820 --> 00:24:43,660 +فبالتالي ال antibody اللي حققناها specific for the + +293 +00:24:43,660 --> 00:24:47,920 +tumor فهيظل يمشي لغاية ما يثلاث يومان هناك بيجف و + +294 +00:24:47,920 --> 00:24:52,560 +بد ايش ال radio labelled material can emit lights + +295 +00:24:52,560 --> 00:24:56,420 +وبالتالي يوم ما نيجي نعمل صورة و ام وجه ال + +296 +00:24:56,420 --> 00:25:06,080 +antibody هيعمل ايش image اللي هو light و هيبين اذا + +297 +00:25:06,080 --> 00:25:10,590 +كان في tumoridentifying and qualifying hormone + +298 +00:25:10,590 --> 00:25:14,790 +طبعا ممكن نبحث هرمونات فيها immuno affinity + +299 +00:25:14,790 --> 00:25:18,210 +purification كمان ممكن نستفيد من عملية + +300 +00:25:18,210 --> 00:25:24,350 +purification of antibody mixtures زي ما انتوا + +301 +00:25:24,350 --> 00:25:28,730 +شايفين طبعا هذا mv2 احنا ممكن نحك بالادنة ال + +302 +00:25:28,730 --> 00:25:34,840 +pathologist ممكن يستخدم عينةيجيب عينة بيوبسي و + +303 +00:25:34,840 --> 00:25:39,120 +يشوف طبعا يضيف عليها منوكلونة antibody مع صبغة + +304 +00:25:39,120 --> 00:25:45,980 +معينة بتدي زكيا موجود اللي هو tumor وينوكيل هذا + +305 +00:25:45,980 --> 00:25:49,560 +طبعا in vitro in vivo sorry احنا ممكن نحقن انه + +306 +00:25:49,560 --> 00:25:54,120 +منوكلونة antibody وطبعا زي ما قلتلكوا radiolabeled + +307 +00:25:54,120 --> 00:25:58,040 +material مربوط ب radiolabeled ونحقن هيظل يمشي + +308 +00:25:58,040 --> 00:26:01,500 +specific to the tumor وإن في tumor بالدرجة في عنده + +309 +00:26:01,970 --> 00:26:06,330 +وهي شعبه فبيستخدم في الـ Azadigostic Technique + +310 +00:26:06,330 --> 00:26:09,710 +أيضا في الـ Affinity Chromatography زي ما انتوا + +311 +00:26:09,710 --> 00:26:15,070 +شايفين فشوفنا قبل هيك نعمل مكسير في الانتيجين هي + +312 +00:26:15,070 --> 00:26:19,270 +Activated Sepharos + +313 +00:26:19,270 --> 00:26:24,070 +يعني عبارة عن بيتز بنحط عليها Antibody Monoclonal + +314 +00:26:24,070 --> 00:26:29,680 +Antibodyطبعا هى كما تشوفون ال affinity عالية لانها + +315 +00:26:29,680 --> 00:26:34,240 +ليها اكتر من ال antibody مربوط بنحطه في mixture of + +316 +00:26:34,240 --> 00:26:39,520 +antigen هيضبط بال antigenطبعا mix of antigen يعني + +317 +00:26:39,520 --> 00:26:41,860 +فيه اكتر من antigen لكن الانتيباطي حاجبت في ال + +318 +00:26:41,860 --> 00:26:45,920 +antigen which is specific to that ناخده و بعدين + +319 +00:26:45,920 --> 00:26:48,940 +بنعمل illusion فبنعمل purification ل ال antigen + +320 +00:26:48,940 --> 00:26:53,360 +purification ل ال antigen طبعا هذا الكلام ممكن + +321 +00:26:53,360 --> 00:26:57,080 +نعمله using chromatography + +322 +00:26:58,210 --> 00:27:02,790 +طبعا هي و بعد هيك هي beats مرتبط فيها antibody + +323 +00:27:02,790 --> 00:27:06,410 +مرتبط في ال antigen اللي احنا بدنا ياه بعد هيك ده + +324 +00:27:06,410 --> 00:27:08,070 +هو و بعد هيك ده هو و بعد هيك ده هو و بعد هيك ده هو + +325 +00:27:08,070 --> 00:27:08,190 +بعد هيك ده هو و بعد هيك ده هو و بعد هيك ده هو و + +326 +00:27:08,190 --> 00:27:08,370 +بعد هيك ده هو و بعد هيك ده هو و بعد هيك ده هو و + +327 +00:27:08,370 --> 00:27:15,270 +بعد هيك ده هو و بعد هيك ده هو و بعد هيك ده هو و + +328 +00:27:15,270 --> 00:27:21,690 +بعد هيك ده هو و بعد هيك ده هو و + +329 +00:27:28,910 --> 00:27:35,990 +طبعا ال ..think that these antibodies have + +330 +00:27:35,990 --> 00:27:40,290 +promising agents promising future for human + +331 +00:27:40,290 --> 00:27:45,090 +therapy يعني بيفكروا في انهم يكونوا دور أساسي في + +332 +00:27:45,090 --> 00:27:49,730 +عملية علاج كثير من الأمراض و منها ال cancer و منها + +333 +00:27:49,730 --> 00:27:54,410 +ال cancer فبيفكروا انهم يستخدموا ال unmonocular + +334 +00:27:54,410 --> 00:27:58,330 +antibody في موضوع بيسموه targeting therapy ايش + +335 +00:27:58,330 --> 00:28:01,780 +يعني targeting therapy يعني بس ال antibodywhich is + +336 +00:28:01,780 --> 00:28:06,740 +specific for certain tumor ممكن نربط في dialogue + +337 +00:28:06,740 --> 00:28:13,720 +chemotherapy و ال chemotherapy هذا يمشي لغاية ما + +338 +00:28:13,720 --> 00:28:17,320 +يصل ال tumor و عند ال tumor فقط يقتل ال tumor cell + +339 +00:28:17,320 --> 00:28:21,720 +سموه targeting therapy لكن للأسف سديد لغاية الآن + +340 +00:28:21,720 --> 00:28:26,240 +ال antigenicity of antibody still a problem + +341 +00:28:30,240 --> 00:28:36,240 +المشكلة انهم يفكرون انهم بمعوث مونوكرونيه انتيبادي + +342 +00:28:36,240 --> 00:28:41,340 +وزي ما قلنا لكوا ان هذا الانتيجن الذي تبعته عالي + +343 +00:28:41,340 --> 00:28:45,840 +يوم ما نحكي انه فيه human هيكون الجسم الإنسان + +344 +00:28:45,840 --> 00:28:49,200 +هيعتبره انتيجن وبالتالي يكون له انتيبادي وبالتالي + +345 +00:28:49,200 --> 00:28:54,330 +فيه rejection لهذا الموضوعفاليوم بيفكروا يعملوا in + +346 +00:28:54,330 --> 00:28:59,050 +genetically engineered antibody to replace the + +347 +00:28:59,050 --> 00:29:05,730 +mouse monoclonal antibody واليوم + +348 +00:29:05,730 --> 00:29:10,730 +بيفكروا كمان with counter انهم يذاكروا هذا ال + +349 +00:29:10,730 --> 00:29:15,450 +antibody يعني ما يحكنوش كل ال antibody وانما + +350 +00:29:15,450 --> 00:29:20,750 +يحكنوا فقط منطقات اللي هي ال hyper variable region + +351 +00:29:23,000 --> 00:29:29,580 +الذي يتعامل بالـ Antigen Binding اليوم بدوا يفكروا + +352 +00:29:29,580 --> 00:29:35,340 +بانهم بيستخدموا human بدلا من mouse antibody كما + +353 +00:29:35,340 --> 00:29:42,080 +تشاهدون كيمريك انتيوادي هو ال mouse + +354 +00:29:44,080 --> 00:29:49,280 +ماشي كيف قالوا احنا بدنا نحقن نجيب antibody طريقة + +355 +00:29:49,280 --> 00:29:53,320 +وقعة نجيب human antibody و فقط ناخد ال Fab region + +356 +00:29:53,320 --> 00:29:58,100 +اللي فيها العي بربريا و ال region من ال mouse و + +357 +00:29:58,100 --> 00:30:04,040 +نركبها genetically by genetic engineering على سطح + +358 +00:30:04,040 --> 00:30:08,800 +هذا ال antibody فهو يصير عندى antibody ماشيالـ + +359 +00:30:08,800 --> 00:30:13,120 +frame تبعه كله human frame لكن ليهش الفعب تبعته من + +360 +00:30:13,120 --> 00:30:17,760 +الرجل طبعا + +361 +00:30:17,760 --> 00:30:21,340 +عشان يقلل ال immunogenicity كمان antibody of + +362 +00:30:21,340 --> 00:30:24,220 +single specificity يعني monochlone كان بي obtained + +363 +00:30:24,220 --> 00:30:29,840 +by cloning ال appropriated heavy enlightened gene + +364 +00:30:29,840 --> 00:30:35,840 +وبالتالي in a vector وبالتالي هذه تقنية أخدته طبعا + +365 +00:30:35,840 --> 00:30:39,690 +في molecular biologyوبالتالي انا ممكن احصل على + +366 +00:30:39,690 --> 00:30:44,150 +antibody engineered Genetically engineered + +367 +00:30:44,150 --> 00:30:48,970 +antibody طبعا هذا هو ال antibody نقل ال antibody + +368 +00:30:48,970 --> 00:30:57,570 +ربطنا في ديلوتوكسين which is specific to certain + +369 +00:30:57,570 --> 00:31:03,030 +bacteria, humor whatever طبعا هذا بيسموه + +370 +00:31:03,030 --> 00:31:11,210 +myonotoxinوبهيك نقوم انهينا المحاضرة اتمنى عليكم + +371 +00:31:11,210 --> 00:31:15,830 +انه ان شاء الله تكونوا قد استمتعتم بها + diff --git a/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/5smAuOfTr-M_raw.srt b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/5smAuOfTr-M_raw.srt new file mode 100644 index 0000000000000000000000000000000000000000..c438d8dc05570f94265a245aecb783c510b39cd2 --- /dev/null +++ b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/5smAuOfTr-M_raw.srt @@ -0,0 +1,1512 @@ +1 +00:00:05,800 --> 00:00:12,120 +السلام عليكم و رحمة الله و بركاته اليوم + +2 +00:00:12,120 --> 00:00:14,440 +ان شاء الله محاضرتنا على الـ Hybrid-OMA Technique + +3 +00:00:18,150 --> 00:00:27,010 +و موضوع بدأ ينحك فيه في ال 1975 لما بدأتوا اعلاني + +4 +00:00:27,010 --> 00:00:32,870 +اتنين two scientist كوهلر و مايلدستاين بدوا يعملوا + +5 +00:00:32,870 --> 00:00:37,770 +fusion في ال lymphocytes يعني يدمجوا lymphocyte مع + +6 +00:00:37,770 --> 00:00:42,030 +بعضها طبعا ماحصلت هذا الكلام production of cell + +7 +00:00:42,030 --> 00:00:49,130 +lineمن خصائصه انه immortal بمعنى انه يبقى موجود + +8 +00:00:49,130 --> 00:00:54,710 +دائما و ينتج انتباد محدث انتباد محدث انتباد محدث + +9 +00:00:54,710 --> 00:00:56,370 +انتباد محدث انتباد محدث انتباد محدث انتباد محدث + +10 +00:00:56,370 --> 00:00:56,470 +انتباد محدث انتباد محدث انتباد محدث انتباد محدث + +11 +00:00:56,470 --> 00:00:58,170 +انتباد محدث انتباد محدث انتباد محدث انتباد محدث + +12 +00:00:58,170 --> 00:00:58,210 +انتباد محدث انتباد محدث انتباد محدث انتباد محدث + +13 +00:00:58,210 --> 00:00:59,010 +انتباد محدث انتباد محدث انتباد محدث انتباد محدث + +14 +00:00:59,010 --> 00:01:03,370 +انتباد محدث انتباد محدث انتباد محدث انتباد + +15 +00:01:03,370 --> 00:01:10,610 +محدث انتباد + +16 +00:01:10,610 --> 00:01:15,830 +ملكنه لم يستغل هذا التقنيك لغاية 1987 يوم ما بدوا + +17 +00:01:15,830 --> 00:01:20,590 +يفكروا يستخدموا ال monoclonal antibody in + +18 +00:01:20,590 --> 00:01:28,930 +diagnostic techniques in + +19 +00:01:28,930 --> 00:01:34,490 +a specific immune response اول ما هي طبعا خلايا + +20 +00:01:34,490 --> 00:01:37,870 +اللي قالتلي تتنشط عند دخول ال antigen هي عبارة عن + +21 +00:01:37,870 --> 00:01:42,880 +كوكتيل من ال B و T lymphocytesوطبعا ال figure واضح + +22 +00:01:42,880 --> 00:01:50,680 +جدا ان هناك كوكتيل من ال B وT الانفوسايت يتصدى + +23 +00:01:50,680 --> 00:01:54,300 +الانتجين هذا الانتجين من صفاته انه يحتوي على ازرق + +24 +00:01:54,300 --> 00:01:58,120 +واحد و أحمر اثناء الانتجين وبالتالي الخلايا التي + +25 +00:01:58,120 --> 00:02:02,400 +تصدت لهذا الانفوسايت هي الخلايا الزرقاء والحمراء + +26 +00:02:02,400 --> 00:02:07,900 +التي تحتوي على مصادر محددة للانفوسايتوصار حاجة + +27 +00:02:07,900 --> 00:02:12,660 +بيسميناها في السابق Clonal Selection ل هذه الخلايا + +28 +00:02:12,660 --> 00:02:18,600 +اللي بعد هي كصار في Clonal Expansion فهذه زي ما + +29 +00:02:18,600 --> 00:02:22,320 +انتوا شايفين الخلايا الزرقى والخلايا الحمرا صار + +30 +00:02:22,320 --> 00:02:27,500 +لها Clonal Expansion after selection صار في + +31 +00:02:27,500 --> 00:02:31,640 +expansion وصار في اني many many cells which have + +32 +00:02:31,640 --> 00:02:36,460 +the same specificity for the two epitopes involved + +33 +00:02:39,120 --> 00:02:42,560 +المحصلة في هذه الحالة هو إنتاج Polyclonal Antibody + +34 +00:02:42,560 --> 00:02:47,620 +لأنه صار في عندي أكتر من Epitopes للـ Antigen تصدت + +35 +00:02:47,620 --> 00:02:52,060 +إليه أكتر من خلية وكل خلية طلعت لنا Antibody for + +36 +00:02:52,060 --> 00:02:54,920 +specific Epitope فصار كوكتيل من ال Epitopes + +37 +00:02:54,920 --> 00:03:01,520 +موجودين فالمحصلة إنتاج Polyclonal Antibody عشان هي + +38 +00:03:01,520 --> 00:03:05,920 +كذا يوم ما يصير فيه immunization لأى animal with a + +39 +00:03:05,920 --> 00:03:12,680 +proteinعدد كبير من الـ B-lymphocyte سيكون مدفع على + +40 +00:03:12,680 --> 00:03:17,820 +الانتبروتين انتبوتين انتبوتين انتبوتين انتبوتين + +41 +00:03:17,820 --> 00:03:19,560 +انتبوتين انتبوتين انتبوتين انتبوتين انتبوتين + +42 +00:03:19,560 --> 00:03:22,220 +انتبوتين انتبوتين انتبوتين انتبوتين انتبوتين + +43 +00:03:22,220 --> 00:03:31,120 +انتبوتين انتبوتين انتبوتين انتبوتين انتبوتين + +44 +00:03:31,120 --> 00:03:33,800 +انتبوتين انتبوتين انتبوتين انتبوتين انتبوتين + +45 +00:03:33,800 --> 00:03:34,200 +انتبوتين انتبوتين انتبوتين انتبوتين انتبوتين + +46 +00:03:34,200 --> 00:03:34,200 +انتبوتين انتبوتين انتبوتين انتبوتين انتبوتين + +47 +00:03:34,200 --> 00:03:35,580 +انتبوتين انتبوتين انتبوتين انتبوتين انتبmay have + +48 +00:03:35,580 --> 00:03:41,500 +different antigen binding sites بمعنى آخر they may + +49 +00:03:41,500 --> 00:03:47,310 +have different affinity to the same epitopeالمحصلة + +50 +00:03:47,310 --> 00:03:51,950 +انه في mixture of antibody produced in response to + +51 +00:03:51,950 --> 00:03:55,790 +that antigen and this these antibodies are called + +52 +00:03:55,790 --> 00:03:59,650 +polyclonal antibody they produced by many + +53 +00:03:59,650 --> 00:04:03,570 +different clones of B lymphocytes طبيعي جدا تهيأ + +54 +00:04:03,570 --> 00:04:07,510 +اليوم ادخل ال antigen وزي ما انتوا شايفين فيه اكتر + +55 +00:04:07,510 --> 00:04:12,050 +من Epitopes لان كل لون بيمثل Epitopes + +56 +00:04:15,100 --> 00:04:21,680 +صح هذا هي ال Epitopes مختلفة عملنا له immunization + +57 +00:04:21,680 --> 00:04:27,960 +ل animal صار فى immune response و المحصلة + +58 +00:04:27,960 --> 00:04:33,600 +different B cell have been stimulatedوكل واحدة + +59 +00:04:33,600 --> 00:04:38,840 +طلعت Antibody specific for certain Epitopes + +60 +00:04:38,840 --> 00:04:46,360 +والمحصلة كوكتيل من ال Antibodies سمناهم Polyclonal + +61 +00:04:46,360 --> 00:04:52,340 +Antibody يعني a mixture of Antibody وكلهم برتبته + +62 +00:04:52,340 --> 00:04:57,520 +بال Epitopes of the original protein or antigen + +63 +00:04:58,910 --> 00:05:05,150 +طبعا في منهم يرتبط بقوة اكتر من التاني يعني ال + +64 +00:05:05,150 --> 00:05:09,190 +affinity to off binding is different these are + +65 +00:05:09,190 --> 00:05:13,050 +called مرة تانية polyclonal antibody يبقى ال + +66 +00:05:13,050 --> 00:05:16,270 +polyclonal antibody are a mixture of antibody with + +67 +00:05:16,270 --> 00:05:19,130 +different antigen binding sites and may have + +68 +00:05:19,130 --> 00:05:23,610 +different may bind to different epitopes of + +69 +00:05:23,610 --> 00:05:30,370 +antigen وين يوم ما يدخللما نعمل immunization for + +70 +00:05:30,370 --> 00:05:37,190 +certain animal فبتكون هناك antibody for immunizing + +71 +00:05:37,190 --> 00:05:42,590 +agents they have varying affinity and they may + +72 +00:05:42,590 --> 00:05:47,300 +have different classes of antibodyالسيرام اللي + +73 +00:05:47,300 --> 00:05:51,680 +اكتشفته ايضا بيسموه polyclonal antiserum ال + +74 +00:05:51,680 --> 00:05:55,000 +polyclonal antiserum بيحتوي على انتيبودي + +75 +00:05:55,000 --> 00:05:59,480 +لإيبيتوبات مختلفة وانتجين مختلفة تحتوي على انتجين + +76 +00:05:59,480 --> 00:06:00,840 +مختلفة تحتوي على انتجين مختلفة تحتوي على انتجين + +77 +00:06:00,840 --> 00:06:00,840 +مختلفة تحتوي على انتجين مختلفة تحتوي على انتجين + +78 +00:06:00,840 --> 00:06:01,780 +مختلفة تحتوي على انتجين مختلفة تحتوي على انتجين + +79 +00:06:01,780 --> 00:06:01,860 +مختلفة تحتوي على انتجين مختلفة تحتوي على انتجين + +80 +00:06:01,860 --> 00:06:02,220 +مختلفة تحتوي على انتجين مختلفة تحتوي على انتجين + +81 +00:06:02,220 --> 00:06:09,500 +مختلفة تحتوي على انتجين مختلفة تحتوي على انتجين + +82 +00:06:09,500 --> 00:06:15,910 +مختلفة تحتوي علىكيف بيصير عملية ال purification زي + +83 +00:06:15,910 --> 00:06:19,410 +ما اتخذته في column chromatography ده هو ندخل + +84 +00:06:19,410 --> 00:06:25,590 +beats عليها antigen specific to certain antibody + +85 +00:06:25,590 --> 00:06:28,750 +من انه انتبادى من الانتبادى اللى موجودة فى ال + +86 +00:06:28,750 --> 00:06:32,570 +mixture اللى بده اعمله purification فطبعا بعد هيك + +87 +00:06:32,570 --> 00:06:37,050 +بنعمل purification لل mixture بيدخل على ال beats + +88 +00:06:37,860 --> 00:06:41,980 +بيرتبط ال antibody اللى بديها which is specific + +89 +00:06:41,980 --> 00:06:48,380 +for the antigen اللى موجود على ال beats و الباقى + +90 +00:06:48,380 --> 00:06:53,560 +بنزل الباقى ال antibody بنزل اللى لبروتينات ال + +91 +00:06:53,560 --> 00:06:58,060 +antibody اللى ليس لها it's not specific for that + +92 +00:06:58,060 --> 00:07:02,180 +antigen يبقى احنا في هذه العملية مسكنا one + +93 +00:07:02,180 --> 00:07:07,810 +antibody من mixture of antibodies والباقى نزلبعد + +94 +00:07:07,810 --> 00:07:08,890 +ذلك بناخد ال beats + +95 +00:07:21,740 --> 00:07:31,280 +طبعا illusion in certain اللي هو mixture + +96 +00:07:31,280 --> 00:07:36,340 +أيوة antigen can be bound to the support matrix in + +97 +00:07:36,340 --> 00:07:39,800 +order to purify antigen specific antibody from + +98 +00:07:39,800 --> 00:07:43,940 +polyclonal antiserum طبعا هذه العملية ممكن تتكرر ب + +99 +00:07:43,940 --> 00:07:47,480 +antigen تانيspecific for antibody برضه في ال + +100 +00:07:47,480 --> 00:07:50,740 +mixture و شوية شوية بنعمل عملية verification لل + +101 +00:07:50,740 --> 00:07:55,560 +antibody واحد ولا التاني هي عندي different B cell + +102 +00:07:55,560 --> 00:07:59,920 +عندها القدرة انها تطلعلي different antibody و + +103 +00:07:59,920 --> 00:08:05,720 +محصلة mixture of antibody طبعا هي احنا ممكن ناخد + +104 +00:08:05,720 --> 00:08:12,790 +one cell تطلعلي one specific antibodyطبعا هذا + +105 +00:08:12,790 --> 00:08:20,430 +الخلية ممكن نعملها culturing و تطلعلي many many + +106 +00:08:20,430 --> 00:08:24,970 +antibody specific to that antigen بعدين بنعمل + +107 +00:08:24,970 --> 00:08:30,600 +harvesting ل ال antibody اللي طلعو في هذه الحالة + +108 +00:08:30,600 --> 00:08:35,460 +لما باخد خلية بتطلع antibody واحد حصلها monoclonal + +109 +00:08:35,460 --> 00:08:38,080 +antibody بس في مشكلة فيها ده ده مش hybridoma + +110 +00:08:38,080 --> 00:08:41,280 +technica ده عبارة عن خلية أخدناها و زرعناها أو + +111 +00:08:41,280 --> 00:08:44,540 +عملنا لها culturing و طلعتناها antibody طبعا بعد + +112 +00:08:44,540 --> 00:08:48,990 +ما هيجناها ب antibodyهذه طبعا طريقة أخرى من طريقة + +113 +00:08:48,990 --> 00:08:53,450 +الفصل انه احنا ناخد فينا different cell طلعت ليه + +114 +00:08:53,450 --> 00:08:56,310 +different antibody طلع عندي mixture of antibody + +115 +00:08:56,310 --> 00:09:00,670 +اخدنا خلية واحدة منها culturing وبتطلعنا ايش + +116 +00:09:00,670 --> 00:09:05,570 +antibody واحد اللي ممكن انه هلاقاش مشكلة في هذه + +117 +00:09:05,570 --> 00:09:09,630 +القضية ان هذه الخلية لها lifespan محدد وبالتالي + +118 +00:09:09,630 --> 00:09:15,150 +هتموت بعد فترةلكن انا معنى باني احصل على خلية + +119 +00:09:15,150 --> 00:09:20,230 +which is immortal هذا الكلام بيتحقق يوم اعمل + +120 +00:09:20,230 --> 00:09:25,490 +hybridoma تقنية ال hybridomas كيف بتصير قالوا + +121 +00:09:25,490 --> 00:09:30,750 +بيليمفوسايت can mutate into tumor cell انا ممكن + +122 +00:09:30,750 --> 00:09:34,250 +اجيب بيليمفوسايت و اعملها mutation وبالتالي تتحول + +123 +00:09:34,250 --> 00:09:39,830 +ل tumor cell و طبعا في هذه الحالة بيسموها myeloma + +124 +00:09:39,830 --> 00:09:45,030 +cellوهو عبارة عن cancer of B lymphocytes او plasma + +125 +00:09:45,030 --> 00:09:50,350 +cell الملومة cell في هذه الحالة become immortal + +126 +00:09:50,350 --> 00:09:53,930 +لأنها صارت tumor و ال tumor is resistant to + +127 +00:09:53,930 --> 00:09:58,150 +apoptosis وبالتالي can grow indefinitely in + +128 +00:09:58,150 --> 00:10:04,050 +culture media طب شو بتعمل في هذه الحالةعشان اعمل + +129 +00:10:04,050 --> 00:10:07,690 +hybrid هما قالوا بنعمل fusion of a single + +130 +00:10:07,690 --> 00:10:11,930 +activated خلاية + +131 +00:10:11,930 --> 00:10:20,830 +محفظة لإنتاج certain antibody بجيب + +132 +00:10:20,830 --> 00:10:25,630 +هذه الخلية اللي عبارة عن activated B cellوبعمل + +133 +00:10:25,630 --> 00:10:30,130 +fusion لهذه الخلية مع myeloma cell اللي انا عملتها + +134 +00:10:30,130 --> 00:10:35,270 +وبالتالي بعمل hybridoma وهو عبارة عن بحصل على خلية + +135 +00:10:35,270 --> 00:10:38,970 +مهجنة that can grow indefinitely in culture media + +136 +00:10:38,970 --> 00:10:44,110 +هذه الخلية بي lymphocytes which can secrete + +137 +00:10:44,110 --> 00:10:46,550 +antibody but do not grow in different tissue + +138 +00:10:46,550 --> 00:10:52,920 +culture وبجيب myeloma cellوهي زمان كما تشايفين + +139 +00:10:52,920 --> 00:10:58,140 +myeloma cell can grow indefinitely in cell culture + +140 +00:10:58,140 --> 00:11:02,360 +but do not secrete the desired antibody اللي فوق + +141 +00:11:02,360 --> 00:11:07,080 +بتطلعلي antibody ها دي mutated and cannot secrete + +142 +00:11:07,080 --> 00:11:13,160 +antibody بعملي fusion بين التنتين هي fusion ثم + +143 +00:11:13,160 --> 00:11:18,540 +بحصل على hybrid oma cellلي عبارة عن خلية هاجين ما + +144 +00:11:18,540 --> 00:11:23,940 +بين البيسل والميلوماسل وهذه الخلية can grow + +145 +00:11:23,940 --> 00:11:28,720 +indefinitely in culture media and can secrete + +146 +00:11:28,720 --> 00:11:33,480 +antibody وهي المحصلة والله باخد هذه الخلية و + +147 +00:11:33,480 --> 00:11:37,660 +بعملها sub-culturing وبالتالي هذه الخلية can grow + +148 +00:11:37,660 --> 00:11:42,360 +indefinitely و بتطلع لي in the same time + +149 +00:11:49,730 --> 00:11:55,170 +الخلية ال بيليمفوسايت اللى احنا حفظناها او قدمنا + +150 +00:11:55,170 --> 00:12:00,070 +لها انتيجن فى البداية فهتكون انتيبادي يبقى + +151 +00:12:00,070 --> 00:12:04,510 +الانتيبادي بيطلع specific for only specific + +152 +00:12:04,510 --> 00:12:08,110 +antigen and this is called monoclonal antibody + +153 +00:12:11,610 --> 00:12:14,190 +يبقى الـ Monoclonal Antibody يبقى ان الانتبادي + +154 +00:12:14,190 --> 00:12:20,530 +ينتج من احدة كلون من بيليمفوسايز وحصلنا عليه من + +155 +00:12:20,530 --> 00:12:24,510 +خلال ال fusion of B cell which secretes the + +156 +00:12:24,510 --> 00:12:29,170 +desired antibody مع myeloma cell which is capable + +157 +00:12:29,170 --> 00:12:33,070 +of growing indefinitely in tissue culture هنحصل + +158 +00:12:33,070 --> 00:12:38,590 +على Monoclonal Antibody which all have identical + +159 +00:12:38,590 --> 00:12:43,810 +antigen binding sitesو يمكنهم أيضًا أن يتعاملوا مع + +160 +00:12:43,810 --> 00:12:50,150 +نفسهم مع نفس الـ Epitope مع نفس الـ Affinity و هم + +161 +00:12:50,150 --> 00:12:55,130 +جميعًا من نفس السلفات الانتيبوديية يبقى شوفوا من + +162 +00:12:55,130 --> 00:12:58,990 +صفات الـ Monoclonal Antibody لديهم مجموعة متعاملة + +163 +00:12:58,990 --> 00:13:01,570 +عنتجينية متعاملة متعاملة متعاملة متعاملة متعاملة + +164 +00:13:01,570 --> 00:13:02,370 +متعاملة متعاملة متعاملة متعاملة متعاملة متعاملة + +165 +00:13:02,370 --> 00:13:05,290 +متعاملة متعاملة متعاملة متعاملة متعاملة متعاملة + +166 +00:13:05,290 --> 00:13:06,290 +متعاملة متعاملة متعاملة متعاملة متعاملة متعاملة + +167 +00:13:06,290 --> 00:13:06,290 +متعاملة متعاملة متعاملة متعاملة متعاملة متعاملة + +168 +00:13:06,290 --> 00:13:09,310 +متعاملة متعاملة متعاملة متعام + +169 +00:13:10,370 --> 00:13:15,790 +كلهم with the same affinity وكل ال antibody are + +170 +00:13:15,790 --> 00:13:21,170 +done من نفس ال class طيب شوفوا ال procedure + +171 +00:13:21,170 --> 00:13:26,930 +بالتفصيل هنا جيبنا فعر وعملنا له immunization و + +172 +00:13:26,930 --> 00:13:33,790 +certain antigen طبعا بعد فترة بناخد ال spleen بعد + +173 +00:13:33,790 --> 00:13:39,630 +أسبوعين بناخد ال spleen تبع الفعر هذاوبناخد منه + +174 +00:13:39,630 --> 00:13:45,390 +الخلايا اللي هي ال B-cell وفي نفس الوقت بنحصل نجيب + +175 +00:13:45,390 --> 00:13:48,610 +tumor cell سواء احنا عملناها او جيبناها already + +176 +00:13:48,610 --> 00:13:54,290 +tumor بنتشره culture وبتنتين بعملهم fusion وبحصل + +177 +00:13:54,290 --> 00:13:57,270 +على hybridoma cell بعملها sub-culturing ده هي + +178 +00:13:57,270 --> 00:14:00,590 +hybridoma which can screened for antibody + +179 +00:14:00,590 --> 00:14:06,230 +production ومحصلها monoclonal antibodyنفس الصورة x + +180 +00:14:06,230 --> 00:14:11,670 +-antigen isolate spleen cell بعد فترة فتحصل عليها + +181 +00:14:11,670 --> 00:14:17,270 +اللي هو mixture of spleen cell بما فيهم ال anti x + +182 +00:14:17,270 --> 00:14:23,150 +-antibody cell مع نجيب mutated mutant myeloma line + +183 +00:14:23,150 --> 00:14:30,230 +unable to grow in hat media الآن هنعرفش يعني hatو + +184 +00:14:30,230 --> 00:14:33,670 +مابينتجش Antibody فبنحصل عليها طبعا تلت أنواع من + +185 +00:14:33,670 --> 00:14:37,550 +الخلايا خلايا ماصلحش Fusion وخلايا already صلها + +186 +00:14:37,550 --> 00:14:42,970 +Fusion وصلحت hybridoma وخلايا tumor cell ماصللها + +187 +00:14:42,970 --> 00:14:46,790 +Fusion تلت أنواع من الخلايا طبعا هذا الكلام مهم + +188 +00:14:46,790 --> 00:14:51,190 +بيصير في culture سموها media لإن ماعرفش ال hat + +189 +00:14:51,190 --> 00:14:56,570 +ماشي و بالتالي ال albionic acid اللي ماصل لها + +190 +00:14:56,570 --> 00:15:03,440 +Fusion هتموت بعد فترةو ال tumor cell برضه هتموت + +191 +00:15:03,440 --> 00:15:07,880 +لأنه لا تستطيع أن تنمو في وسط اللي حطناها فيه + +192 +00:15:07,880 --> 00:15:10,780 +لولها ال media فبتبقى ال hybrid هو ما هي اللي + +193 +00:15:10,780 --> 00:15:17,920 +بتبقى عايشة خلايا بتموت تلات أنواع ناخدها بعد هيك + +194 +00:15:17,920 --> 00:15:24,270 +و نعملها sub-culturing و تحصل علاج على خلايانفس + +195 +00:15:24,270 --> 00:15:28,810 +الصورة هي two cells fused antibody-screening B + +196 +00:15:28,810 --> 00:15:32,810 +lymphocyte hybridoma cell طلعت منها نفس اللي احكى + +197 +00:15:32,810 --> 00:15:43,430 +هو دي صورة لها اللي هو ال 69 well plate بنعمل فيه + +198 +00:15:43,430 --> 00:15:51,370 +culturing بنخفف اللي هو dilution معين لل hybridoma + +199 +00:15:51,370 --> 00:15:56,540 +cell line و بنحصل علىاللي هي خلايا عديدة و بنعمل + +200 +00:15:56,540 --> 00:16:04,520 +sub-culturing و طول ما هي بتنتج طبعا هي الخلايا + +201 +00:16:04,520 --> 00:16:10,260 +اللي هي في ال culture tissue culture ممكن نفحصها + +202 +00:16:10,260 --> 00:16:15,790 +by inverted microscope اللي هيخلايا عايشة ولا ميتة + +203 +00:16:15,790 --> 00:16:24,190 +وهكذا وهذه صورة لعملية تخزين لهذه الخلايا فاطفى + +204 +00:16:24,190 --> 00:16:31,090 +طبعا اللى هو incubators درجات حرارة متدنية عشان + +205 +00:16:31,090 --> 00:16:39,830 +تنحفظ طيب نجى لل hybridoma technique بتفاصيلته + +206 +00:16:41,380 --> 00:16:45,540 +أول شيء ميلوما سيل هف بين genetically engineered + +207 +00:16:45,540 --> 00:16:52,640 +ماشي لعبوا فيها genetically بحيث انه these cell + +208 +00:16:52,640 --> 00:16:58,280 +they cannot use hypoxanthine امينوبترين انثايميدين + +209 +00:16:58,280 --> 00:17:03,960 +لكل هات ميديا يعني لو حطناها في هات ميديا ما بتقدر + +210 +00:17:03,960 --> 00:17:08,020 +تنقو في هذا ال medium و هدولة نيكليوب اللي هو + +211 +00:17:08,020 --> 00:17:14,510 +نيكليوبروتين او نيكليوبروتينفيوم ما نعملها و نحطها + +212 +00:17:14,510 --> 00:17:19,710 +في ال culture يحتوي على هذه المواد لأ تستطيع ان + +213 +00:17:19,710 --> 00:17:22,670 +تمويلها لعبنا فيها genetically اخدوا منها انزايم + +214 +00:17:22,670 --> 00:17:28,130 +عندنا هنشوفه ايش هو الانزايم طيب الحاجة التانية + +215 +00:17:28,130 --> 00:17:31,800 +only be cells that have usedwith the engineered + +216 +00:17:31,800 --> 00:17:34,760 +myeloma cell will survive بقى ال hybrid myeloma + +217 +00:17:34,760 --> 00:17:38,500 +cell اللى طلعت اللى هى اللى بتستطيع انها عياش تنمو + +218 +00:17:38,500 --> 00:17:44,820 +وهى نفس الحكاية كيف عملوه لقالوا شعلوا اللى هو + +219 +00:17:44,820 --> 00:17:47,980 +الانزيم هذا اللى هو عبارة عن hypoxanthin guanine + +220 +00:17:47,980 --> 00:17:51,460 +phosphoribosyl transferase enzyme ايه و it's + +221 +00:17:51,460 --> 00:17:55,580 +negative myeloma cell مشهور منها مين هذا الانزيم + +222 +00:17:55,580 --> 00:17:59,500 +اللى هو hypoxanthin guanine phosphoribosyl + +223 +00:17:59,500 --> 00:18:05,760 +transferaseانزاين نيجاتيف يعني ايش مشهور منها و + +224 +00:18:05,760 --> 00:18:15,080 +بنجيب طبعا ال بي لينفوسايز هذه و بنعمل fusion نحصل + +225 +00:18:15,080 --> 00:18:19,380 +على hybridoma cell ماشي هي ال viable طبعا احنا + +226 +00:18:19,380 --> 00:18:23,960 +حصلنا على تلت خلايا خلايا لم myeloma cell ماصلها + +227 +00:18:23,960 --> 00:18:30,030 +في fusion وبي لينفوسايز ماصلها في fusion وهيبردومة + +228 +00:18:30,030 --> 00:18:34,710 +cell صار لها fusion ماشي لو حتى لو ان فيها media + +229 +00:18:34,710 --> 00:18:39,850 +طبعا ما ينمو و يستمر في النمو و ال hybrid + +230 +00:19:02,220 --> 00:19:08,060 +خطوات ال practical steps نعمل immunization ل + +231 +00:19:08,060 --> 00:19:13,130 +animal بعدأسبوعين نعمل isolation للـ spleen cell + +232 +00:19:13,130 --> 00:19:17,490 +وهذه تحتوي على antibody producing B lymphocyte ثم + +233 +00:19:17,490 --> 00:19:21,630 +نعمل fusion للـ spleen cell مع myeloma cell وطبعا + +234 +00:19:21,630 --> 00:19:25,830 +ما يساعد على عملية ال fusion استخدامنا لل PEG اللي + +235 +00:19:25,830 --> 00:19:31,610 +هو polyethylene glycol substance او material اللي + +236 +00:19:31,610 --> 00:19:35,650 +بيعمل fusion بيساعد على fusion طبعا allow unfused + +237 +00:19:35,650 --> 00:19:37,630 +B lymphocyte to die استنى عليها + +238 +00:19:44,960 --> 00:19:48,880 +عشان تقتل من الميلوما سيل اللي برضه مابتقدر تعيش + +239 +00:19:48,880 --> 00:19:53,800 +في هذا ال media بيضال من ال hybrid clone remaining + +240 +00:19:53,800 --> 00:19:58,720 +cell تاخدها و تعملها cloning تاخد one cell في كل + +241 +00:19:58,720 --> 00:20:06,670 +wellمن ال 96 wells و سيبهم ت grow into a clone of + +242 +00:20:06,670 --> 00:20:12,150 +cells تاخد ال supernatant و تعمله screening و تشوف + +243 +00:20:12,150 --> 00:20:16,930 +في ال antibody اللي انت بتدور عليه انتج ولا لم + +244 +00:20:16,930 --> 00:20:23,670 +ينتج و طبعا اذا كان انتج ابدا تنمي هذه الخلايا + +245 +00:20:25,390 --> 00:20:30,050 +culture indefinitely by subculture continuous + +246 +00:20:30,050 --> 00:20:35,230 +subculturing طبعا و كل مرة اعملها harvesting لل + +247 +00:20:35,230 --> 00:20:39,630 +antibody من ال supernatant تبع ال culture و طبعا + +248 +00:20:39,630 --> 00:20:46,410 +بيقولوا ان كل one milligram بيساوي من الف لألفين + +249 +00:20:46,410 --> 00:20:53,810 +دولار هي الطريقة هي عبارة عن myeloma cell شيلنا + +250 +00:20:53,810 --> 00:20:58,320 +منها الحيبوذانتينما بتقدرش تنتج immunoglobulin and + +251 +00:20:58,320 --> 00:21:03,920 +immortal وهي أنتج انحققناها في الفعر خدنا ال B + +252 +00:21:03,920 --> 00:21:08,120 +lymphocyte بسموها primed شو يعني primed يعني موجهة + +253 +00:21:08,120 --> 00:21:14,340 +لإنتاج antibody معين primed عشان يعني العيبوزنثين + +254 +00:21:14,340 --> 00:21:20,180 +موجود enzyme تستطيع تنتج antibody and mortal + +255 +00:21:20,180 --> 00:21:24,380 +mortal يعني حتموت بعد فترة بنحط ال polyethylene + +256 +00:21:24,380 --> 00:21:28,540 +glycolعشان نساعد على fusion هنحصل على تلات أنواع + +257 +00:21:28,540 --> 00:21:33,160 +من الخلايا هي ال hybrid cell line وهي unfused + +258 +00:21:33,160 --> 00:21:37,320 +myeloma و unfused main B lymphocyte طبعا unfused B + +259 +00:21:37,320 --> 00:21:41,200 +lymphocyte هتموت و بعد هيك بنحط اللي هو ال head + +260 +00:21:41,200 --> 00:21:45,980 +selection media ال myeloma هتموت و هيظلمين ال + +261 +00:21:45,980 --> 00:21:51,950 +hybrid اللي عملها cloningما هي ال culturing و ال + +262 +00:21:51,950 --> 00:21:56,890 +sub-culturing بتام دي طريقة اخرى من طرق ال + +263 +00:21:56,890 --> 00:22:03,450 +incubation او عملية الحقن + +264 +00:22:03,450 --> 00:22:11,470 +لها دي للفار في ال plural cavity فبصير فيه إنتاج + +265 +00:22:11,470 --> 00:22:15,850 +لكميات كبيرة من ال hybrid cell وبالتالي antibody + +266 +00:22:15,850 --> 00:22:22,610 +producing cellطبعا هذا cultivation in vitro وهي + +267 +00:22:22,610 --> 00:22:27,230 +جدول بيبين الفروقات ما بين ال polyclonal antibody + +268 +00:22:27,230 --> 00:22:31,290 +و ال monoclonal antibody هذه ال polyclonal اللى + +269 +00:22:31,290 --> 00:22:37,490 +بتنتجها many B cell clones بينما ال monoclonal + +270 +00:22:37,490 --> 00:22:42,950 +single B cell clone الارتباط هذا ال polyclonal + +271 +00:22:42,950 --> 00:22:48,210 +اللى ارتبط بال multiple epitopes على ال antigen + +272 +00:22:49,690 --> 00:22:53,630 +بينما الـ Monoclonal Single Epitopes Antibody + +273 +00:22:53,630 --> 00:22:57,730 +Class هنا Mixer of Classes And One Single Class + +274 +00:22:57,730 --> 00:23:02,670 +Antibody Binding Site هنا Mixer of Antibody With + +275 +00:23:02,670 --> 00:23:06,730 +Different Antigen Binding Sites بينما في الـ + +276 +00:23:06,730 --> 00:23:11,330 +Monoclonal كلهم اللي هم نفس ال Antigen Binding + +277 +00:23:11,330 --> 00:23:16,150 +Sites ال potential for cross reactivity طبيعي في + +278 +00:23:16,150 --> 00:23:20,330 +ال Polyclonal في cross reactivity عالية جداومدينة + +279 +00:23:20,330 --> 00:23:25,790 +false positive results بينما في ال monoclonal ال + +280 +00:23:25,790 --> 00:23:32,570 +cross reactivity is low or even absent طيب ما هي + +281 +00:23:32,570 --> 00:23:36,750 +استخدامات ال monoclonal antibody جالون من لو حد ما + +282 +00:23:36,750 --> 00:23:40,170 +جاريك protein and drug level in serum وطبعا كل + +283 +00:23:40,170 --> 00:23:43,470 +الكتات اللي بنشوفها في المعامل هي عبارة عن + +284 +00:23:43,470 --> 00:23:46,910 +antibody specific for antigen + +285 +00:23:53,380 --> 00:24:00,040 +نمر اتنين is typing tissue احنا بنعرف الاماثي اللى + +286 +00:24:00,040 --> 00:24:05,720 +على سطح نوعه اللى على سطح الغلايا by using certain + +287 +00:24:05,720 --> 00:24:08,800 +او specific molecular antibody نمر اتنين is + +288 +00:24:08,800 --> 00:24:13,130 +identifying effectuous agents طبيعى4 Identifying + +289 +00:24:13,130 --> 00:24:15,790 +clusters of differentiation كمان نعمل + +290 +00:24:15,790 --> 00:24:21,730 +immunophenotyping للخلايا و بنعرف اللي هو types of + +291 +00:24:21,730 --> 00:24:27,090 +lymphoma or leukemia Identifying tumor metastases + +292 +00:24:27,090 --> 00:24:30,850 +وهذا بيستخدموه في ال diagnostic technique طبعا كيف + +293 +00:24:30,850 --> 00:24:35,950 +بيعرفوا ال metastases من خلال حقن ال monoclonal + +294 +00:24:35,950 --> 00:24:39,820 +antibody و بربط في ديلوradio labelled material + +295 +00:24:39,820 --> 00:24:43,660 +فبالتالي ال antibody اللي حققناها specific for the + +296 +00:24:43,660 --> 00:24:47,920 +tumor فهيظل يمشي لغاية ما يثلاث يومان هناك بيجف و + +297 +00:24:47,920 --> 00:24:52,560 +بد ايش ال radio labelled material can emit lights + +298 +00:24:52,560 --> 00:24:56,420 +وبالتالي يوم ما نيجي نعمل صورة و ام وجه ال + +299 +00:24:56,420 --> 00:25:06,080 +antibody هيعمل ايش image اللي هو light و هيبين اذا + +300 +00:25:06,080 --> 00:25:10,590 +كان في tumoridentifying and qualifying hormone + +301 +00:25:10,590 --> 00:25:14,790 +طبعا ممكن نبحث هرمونات فيها immuno affinity + +302 +00:25:14,790 --> 00:25:18,210 +purification كمان ممكن نستفيد من عملية + +303 +00:25:18,210 --> 00:25:24,350 +purification of antibody mixtures زي ما انتوا + +304 +00:25:24,350 --> 00:25:28,730 +شايفين طبعا هذا mv2 احنا ممكن نحك بالادنة ال + +305 +00:25:28,730 --> 00:25:34,840 +pathologist ممكن يستخدم عينةيجيب عينة بيوبسي و + +306 +00:25:34,840 --> 00:25:39,120 +يشوف طبعا يضيف عليها منوكلونة antibody مع صبغة + +307 +00:25:39,120 --> 00:25:45,980 +معينة بتدي زكيا موجود اللي هو tumor وينوكيل هذا + +308 +00:25:45,980 --> 00:25:49,560 +طبعا in vitro in vivo sorry احنا ممكن نحقن انه + +309 +00:25:49,560 --> 00:25:54,120 +منوكلونة antibody وطبعا زي ما قلتلكوا radiolabeled + +310 +00:25:54,120 --> 00:25:58,040 +material مربوط ب radiolabeled ونحقن هيظل يمشي + +311 +00:25:58,040 --> 00:26:01,500 +specific to the tumor وإن في tumor بالدرجة في عنده + +312 +00:26:01,970 --> 00:26:06,330 +وهي شعبه فبيستخدم في الـ Azadigostic Technique + +313 +00:26:06,330 --> 00:26:09,710 +أيضا في الـ Affinity Chromatography زي ما انتوا + +314 +00:26:09,710 --> 00:26:15,070 +شايفين فشوفنا قبل هيك نعمل مكسير في الانتيجين هي + +315 +00:26:15,070 --> 00:26:19,270 +Activated Sepharos + +316 +00:26:19,270 --> 00:26:24,070 +يعني عبارة عن بيتز بنحط عليها Antibody Monoclonal + +317 +00:26:24,070 --> 00:26:29,680 +Antibodyطبعا هى كما تشوفون ال affinity عالية لانها + +318 +00:26:29,680 --> 00:26:34,240 +ليها اكتر من ال antibody مربوط بنحطه في mixture of + +319 +00:26:34,240 --> 00:26:39,520 +antigen هيضبط بال antigenطبعا mix of antigen يعني + +320 +00:26:39,520 --> 00:26:41,860 +فيه اكتر من antigen لكن الانتيباطي حاجبت في ال + +321 +00:26:41,860 --> 00:26:45,920 +antigen which is specific to that ناخده و بعدين + +322 +00:26:45,920 --> 00:26:48,940 +بنعمل illusion فبنعمل purification ل ال antigen + +323 +00:26:48,940 --> 00:26:53,360 +purification ل ال antigen طبعا هذا الكلام ممكن + +324 +00:26:53,360 --> 00:26:57,080 +نعمله using chromatography + +325 +00:26:58,210 --> 00:27:02,790 +طبعا هي و بعد هيك هي beats مرتبط فيها antibody + +326 +00:27:02,790 --> 00:27:06,410 +مرتبط في ال antigen اللي احنا بدنا ياه بعد هيك ده + +327 +00:27:06,410 --> 00:27:08,070 +هو و بعد هيك ده هو و بعد هيك ده هو و بعد هيك ده هو + +328 +00:27:08,070 --> 00:27:08,070 +و بعد هيك ده هو و بعد هيك ده هو و بعد هيك ده هو و + +329 +00:27:08,070 --> 00:27:08,070 +بعد هيك ده هو و بعد هيك ده هو و بعد هيك ده هو و + +330 +00:27:08,070 --> 00:27:08,070 +بعد هيك ده هو و بعد هيك ده هو و بعد هيك ده هو و + +331 +00:27:08,070 --> 00:27:08,190 +بعد هيك ده هو و بعد هيك ده هو و بعد هيك ده هو و + +332 +00:27:08,190 --> 00:27:08,190 +بعد هيك ده هو و بعد هيك ده هو و بعد هيك ده هو و + +333 +00:27:08,190 --> 00:27:08,370 +بعد هيك ده هو و بعد هيك ده هو و بعد هيك ده هو و + +334 +00:27:08,370 --> 00:27:15,270 +بعد هيك ده هو و بعد هيك ده هو و بعد هيك ده هو و + +335 +00:27:15,270 --> 00:27:21,690 +بعد هيك ده هو و بعد هيك ده هو و + +336 +00:27:28,910 --> 00:27:35,990 +طبعا ال ..think that these antibodies have + +337 +00:27:35,990 --> 00:27:40,290 +promising agents promising future for human + +338 +00:27:40,290 --> 00:27:45,090 +therapy يعني بيفكروا في انهم يكونوا دور أساسي في + +339 +00:27:45,090 --> 00:27:49,730 +عملية علاج كثير من الأمراض و منها ال cancer و منها + +340 +00:27:49,730 --> 00:27:54,410 +ال cancer فبيفكروا انهم يستخدموا ال unmonocular + +341 +00:27:54,410 --> 00:27:58,330 +antibody في موضوع بيسموه targeting therapy ايش + +342 +00:27:58,330 --> 00:28:01,780 +يعني targeting therapy يعني بس ال antibodywhich is + +343 +00:28:01,780 --> 00:28:06,740 +specific for certain tumor ممكن نربط في dialogue + +344 +00:28:06,740 --> 00:28:13,720 +chemotherapy و ال chemotherapy هذا يمشي لغاية ما + +345 +00:28:13,720 --> 00:28:17,320 +يصل ال tumor و عند ال tumor فقط يقتل ال tumor cell + +346 +00:28:17,320 --> 00:28:21,720 +سموه targeting therapy لكن للأسف سديد لغاية الآن + +347 +00:28:21,720 --> 00:28:26,240 +ال antigenicity of antibody still a problem + +348 +00:28:30,240 --> 00:28:36,240 +المشكلة انهم يفكرون انهم بمعوث مونوكرونيه انتيبادي + +349 +00:28:36,240 --> 00:28:41,340 +وزي ما قلنا لكوا ان هذا الانتيجن الذي تبعته عالي + +350 +00:28:41,340 --> 00:28:45,840 +يوم ما نحكي انه فيه human هيكون الجسم الإنسان + +351 +00:28:45,840 --> 00:28:49,200 +هيعتبره انتيجن وبالتالي يكون له انتيبادي وبالتالي + +352 +00:28:49,200 --> 00:28:54,330 +فيه rejection لهذا الموضوعفاليوم بيفكروا يعملوا in + +353 +00:28:54,330 --> 00:28:59,050 +genetically engineered antibody to replace the + +354 +00:28:59,050 --> 00:29:05,730 +mouse monoclonal antibody واليوم + +355 +00:29:05,730 --> 00:29:10,730 +بيفكروا كمان with counter انهم يذاكروا هذا ال + +356 +00:29:10,730 --> 00:29:15,450 +antibody يعني ما يحكنوش كل ال antibody وانما + +357 +00:29:15,450 --> 00:29:20,750 +يحكنوا فقط منطقات اللي هي ال hyper variable region + +358 +00:29:23,000 --> 00:29:29,580 +الذي يتعامل بالـ Antigen Binding اليوم بدوا يفكروا + +359 +00:29:29,580 --> 00:29:35,340 +بانهم بيستخدموا human بدلا من mouse antibody كما + +360 +00:29:35,340 --> 00:29:42,080 +تشاهدون كيمريك انتيوادي هو ال mouse + +361 +00:29:44,080 --> 00:29:49,280 +ماشي كيف قالوا احنا بدنا نحقن نجيب antibody طريقة + +362 +00:29:49,280 --> 00:29:53,320 +وقعة نجيب human antibody و فقط ناخد ال Fab region + +363 +00:29:53,320 --> 00:29:58,100 +اللي فيها العي بربريا و ال region من ال mouse و + +364 +00:29:58,100 --> 00:30:04,040 +نركبها genetically by genetic engineering على سطح + +365 +00:30:04,040 --> 00:30:08,800 +هذا ال antibody فهو يصير عندى antibody ماشيالـ + +366 +00:30:08,800 --> 00:30:13,120 +frame تبعه كله human frame لكن ليهش الفعب تبعته من + +367 +00:30:13,120 --> 00:30:17,760 +الرجل طبعا + +368 +00:30:17,760 --> 00:30:21,340 +عشان يقلل ال immunogenicity كمان antibody of + +369 +00:30:21,340 --> 00:30:24,220 +single specificity يعني monochlone كان بي obtained + +370 +00:30:24,220 --> 00:30:29,840 +by cloning ال appropriated heavy enlightened gene + +371 +00:30:29,840 --> 00:30:35,840 +وبالتالي in a vector وبالتالي هذه تقنية أخدته طبعا + +372 +00:30:35,840 --> 00:30:39,690 +في molecular biologyوبالتالي انا ممكن احصل على + +373 +00:30:39,690 --> 00:30:44,150 +antibody engineered Genetically engineered + +374 +00:30:44,150 --> 00:30:48,970 +antibody طبعا هذا هو ال antibody نقل ال antibody + +375 +00:30:48,970 --> 00:30:57,570 +ربطنا في ديلوتوكسين which is specific to certain + +376 +00:30:57,570 --> 00:31:03,030 +bacteria, humor whatever طبعا هذا بيسموه + +377 +00:31:03,030 --> 00:31:11,210 +myonotoxinوبهيك نقوم انهينا المحاضرة اتمنى عليكم + +378 +00:31:11,210 --> 00:31:15,830 +انه ان شاء الله تكونوا قد استمتعتم بها + diff --git a/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/8OI_PaDYsK0_raw.json b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/8OI_PaDYsK0_raw.json new file mode 100644 index 0000000000000000000000000000000000000000..d57233c9b78cad38f61610a04cd44d0686f5fa5c --- /dev/null +++ b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/8OI_PaDYsK0_raw.json @@ -0,0 +1 @@ +{"segments": [{"id": 1, "seek": 3086, "start": 2.28, "end": 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42.67, "end": 43.15, "word": " الاش", "probability": 0.4168701171875}, {"start": 43.15, "end": 44.69, "word": " and", "probability": 0.4423828125}, {"start": 44.69, "end": 44.85, "word": " they", "probability": 0.8427734375}, {"start": 44.85, "end": 44.99, "word": " are", "probability": 0.75537109375}, {"start": 44.99, "end": 45.55, "word": " collectively", "probability": 0.90966796875}, {"start": 45.55, "end": 47.53, "word": " form", "probability": 0.73681640625}, {"start": 47.53, "end": 48.39, "word": " the", "probability": 0.880859375}, {"start": 48.39, "end": 49.09, "word": " TCR", "probability": 0.888916015625}, {"start": 49.09, "end": 49.97, "word": " complex", "probability": 0.6064453125}, {"start": 49.97, "end": 54.05, "word": " ال", "probability": 0.72021484375}, {"start": 54.05, "end": 55.19, "word": " mature", "probability": 0.97216796875}, {"start": 55.19, "end": 55.45, "word": " T", "probability": 0.92529296875}, {"start": 55.45, "end": 55.83, "word": " cell", 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"end": 81.1, "word": " Beta", "probability": 0.89013671875}, {"start": 81.1, "end": 81.94, "word": " Gamma", "probability": 0.6234130859375}, {"start": 81.94, "end": 82.16, "word": " Delta", "probability": 0.939453125}, {"start": 82.16, "end": 82.52, "word": " لغاية", "probability": 0.900634765625}, {"start": 82.52, "end": 82.74, "word": " الآن", "probability": 0.750244140625}, {"start": 82.74, "end": 83.34, "word": " وظيفتها", "probability": 0.97841796875}, {"start": 83.34, "end": 83.7, "word": " مابن", "probability": 0.7604166666666666}, {"start": 83.7, "end": 84.02, "word": " عرف", "probability": 0.7373046875}, {"start": 84.02, "end": 85.14, "word": " إيه", "probability": 0.709228515625}, {"start": 85.14, "end": 85.44, "word": " الشي", "probability": 0.881591796875}], "temperature": 1.0}, {"id": 4, "seek": 10762, "start": 86.58, "end": 107.62, "text": "وهذا هو الـ Structure of TCR زي ما انتوا شايفين في عندنا TCR هو عبارة عن Antigen Receptor which only bind with Antigen ثم في عندي two molecule هده CD3Z molecule مسئولين عن Signal Transduction وزي ما انتوا شايفين في Intracytoplasmic portion for both", "tokens": [2407, 3224, 15730, 31439, 2423, 39184, 745, 2885, 295, 314, 18547, 30767, 1829, 19446, 16472, 2655, 14407, 13412, 995, 33911, 9957, 8978, 43242, 8315, 314, 18547, 31439, 6225, 3555, 9640, 3660, 18871, 5130, 3213, 1300, 1336, 284, 597, 787, 14786, 365, 5130, 3213, 38637, 2304, 8978, 18871, 16254, 732, 15582, 8032, 3215, 3224, 6743, 18, 57, 15582, 47524, 19986, 12610, 9957, 18871, 43414, 6531, 40335, 4032, 11622, 1829, 19446, 16472, 2655, 14407, 13412, 995, 33911, 9957, 8978, 5681, 424, 1344, 19337, 7743, 13195, 8044, 337, 1293], "avg_logprob": -0.3536278838398813, "compression_ratio": 1.4618834080717489, "no_speech_prob": 7.62939453125e-06, "words": [{"start": 86.58, "end": 87.08, "word": "وهذا", "probability": 0.5999348958333334}, {"start": 87.08, "end": 87.28, "word": " هو", "probability": 0.9326171875}, {"start": 87.28, "end": 87.38, "word": " الـ", 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{"start": 213.89, "end": 215.47, "word": " portion", "probability": 0.55419921875}, {"start": 215.47, "end": 215.93, "word": " و", "probability": 0.97412109375}, {"start": 215.93, "end": 216.49, "word": " Constant", "probability": 0.83544921875}, {"start": 216.49, "end": 216.95, "word": " portion", "probability": 0.87255859375}, {"start": 216.95, "end": 217.29, "word": " طبعا", "probability": 0.9500732421875}, {"start": 217.29, "end": 217.37, "word": " ال", "probability": 0.68896484375}, {"start": 217.37, "end": 217.69, "word": " Variable", "probability": 0.7386474609375}, {"start": 217.69, "end": 218.09, "word": " portion", "probability": 0.89453125}, {"start": 218.09, "end": 218.31, "word": " هو", "probability": 0.88134765625}, {"start": 218.31, "end": 218.49, "word": " اللي", "probability": 0.697998046875}, {"start": 218.49, "end": 218.81, "word": " إيش", "probability": 0.8837890625}, {"start": 218.81, "end": 219.47, "word": " ال", "probability": 0.50732421875}, {"start": 219.47, 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تتكوّم من هيتشين و هيبتشين يعني هدا هي هي ال structure قابر عن extracellular portion هدا هو و transmembrane و short cytoplasmic في ال extracellular portion قلنا زي ما انتوا شايفين بيتكوّم من variable", "tokens": [9566, 3555, 3615, 995, 1975, 1829, 11242, 995, 50239, 14407, 16472, 1184, 26424, 9154, 2423, 7006, 4032, 2423, 5754, 6055, 2655, 4117, 2407, 11703, 2304, 9154, 8032, 36081, 8592, 9957, 4032, 8032, 1829, 3555, 2655, 8592, 9957, 37495, 22653, 8032, 28259, 39896, 39896, 2423, 3877, 12174, 16758, 2288, 18871, 2857, 4164, 1040, 8044, 8032, 28259, 31439, 4032, 7715, 443, 1443, 1929, 4032, 2099, 3185, 19337, 7743, 13195, 8978, 2423, 2857, 4164, 1040, 8044, 12174, 1211, 8315, 30767, 1829, 19446, 16472, 2655, 14407, 13412, 995, 33911, 9957, 4724, 36081, 4117, 2407, 11703, 2304, 9154, 7006], "avg_logprob": -0.3690789586619327, "compression_ratio": 1.665137614678899, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 254.78, "end": 255.26, "word": "طبعا", "probability": 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lymphocyte طبعا نفس الحكاية ال variable region فيها ال complementary determining region اللي هي الطرفية وهي متغيرة وهي اللي بتحدد specificity تبعت ال DCR جابوا CDR ال alpha chain", "tokens": [6027, 39184, 363, 31070, 31078, 975, 23032, 3555, 3615, 995, 8717, 36178, 21542, 4117, 995, 10632, 2423, 7006, 4458, 8978, 11296, 2423, 40705, 23751, 4458, 13672, 1829, 39896, 41950, 28480, 10632, 37037, 1829, 44650, 17082, 48923, 37037, 1829, 13672, 1829, 39894, 24401, 3215, 2685, 507, 6055, 3555, 34268, 2423, 9114, 49, 10874, 16758, 14407, 6743, 49, 2423, 8961, 5021], "avg_logprob": -0.2591145803531011, "compression_ratio": 1.3473684210526315, "no_speech_prob": 5.960464477539062e-07, "words": [{"start": 311.85, "end": 313.09, "word": "الـ", "probability": 0.49951171875}, {"start": 313.09, "end": 313.31, "word": " B", "probability": 0.2459716796875}, {"start": 313.31, "end": 314.07, "word": " lymphocyte", "probability": 0.9132486979166666}, {"start": 314.07, "end": 315.99, "word": " طبعا", 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Recombination زي ما حدث في ال Immunoglobulin ال Beta جين Locus", "tokens": [11622, 1829, 19446, 11331, 3215, 12984, 8978, 2423, 39184, 5130, 897, 843, 8978, 2423, 39184, 13154, 45841, 12176, 259, 3714, 33599, 1829, 1975, 5016, 8315, 8978, 8315, 20588, 4032, 33286, 10874, 9957, 3714, 43042, 2407, 4724, 1829, 9381, 13546, 8978, 16095, 1975, 1829, 8592, 13672, 1829, 31439, 1300, 38763, 2486, 30767, 1829, 19446, 11331, 3215, 12984, 8978, 2423, 17322, 409, 45841, 12176, 259, 2423, 33286, 10874, 9957, 12859, 301], "avg_logprob": -0.3323660692998341, "compression_ratio": 1.5157232704402517, "no_speech_prob": 0.0, "words": [{"start": 420.59, "end": 420.97, "word": "زي", "probability": 0.5009765625}, {"start": 420.97, "end": 421.21, "word": " ما", "probability": 0.68603515625}, {"start": 421.21, "end": 421.41, "word": " حدث", "probability": 0.6487630208333334}, {"start": 421.41, "end": 421.63, "word": " في", "probability": 0.703125}, {"start": 421.63, "end": 421.79, "word": " الـ", 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0.8829752604166666}, {"start": 1816.79, "end": 1818.57, "word": " و", "probability": 0.444091796875}, {"start": 1818.57, "end": 1819.03, "word": " شكرا", "probability": 0.873046875}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 1819.329875, "duration_after_vad": 1759.3706249999968} \ No newline at end of file diff --git a/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/9HiEsDjl9XE.srt b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/9HiEsDjl9XE.srt new file mode 100644 index 0000000000000000000000000000000000000000..af865b6ab4feb6c680cf6fa1bdb3d7bd92ecbf43 --- /dev/null +++ b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/9HiEsDjl9XE.srt @@ -0,0 +1,1515 @@ +1 +00:00:01,380 --> 00:00:07,080 +باسمه تعالى ننتقل اليوم في محاضرة جديدة بعنوان الـ major + +2 +00:00:07,080 --> 00:00:10,640 +histocompatibility complex and antigen + +3 +00:00:10,640 --> 00:00:17,400 +presentation ال + +4 +00:00:17,400 --> 00:00:22,260 +major histocompatibility complex هم مجموعات جينية + +5 +00:00:22,260 --> 00:00:25,620 +مرتبطة جدًا ووظيفتهم + +6 +00:00:25,620 --> 00:00:29,260 +الأساسية هي عبارة عن intracellular recognition + +7 +00:00:31,750 --> 00:00:38,510 +of antigen and self-nonself discrimination وي لهم وظائف + +8 +00:00:38,510 --> 00:00:43,230 +مهمة جدا في ال transplantation مسؤولين عن + +9 +00:00:43,230 --> 00:00:48,630 +transplant rejection شوان كان في حالة الhistoin + +10 +00:00:48,630 --> 00:00:53,150 +compatibility كمان لهم دور في ال humor and self + +11 +00:00:53,150 --> 00:00:59,140 +-mediated immunity ولهم دور مهم جدا في الـ Antigen + +12 +00:00:59,140 --> 00:01:04,400 +recognition by T lymphocytes أول + +13 +00:01:04,400 --> 00:01:08,580 +من حكى في هذا الموضوع هو جورج سنيل في 1930 في + +14 +00:01:08,580 --> 00:01:13,460 +1980 أخذ نوبل برايز على هذا الموضوع ال location + +15 +00:01:13,460 --> 00:01:17,840 +لهذه الجينات أن ال human موجودة على كروموسوم رقم + +16 +00:01:17,840 --> 00:01:23,200 +6 و بيسموها MHC major histocompatibility complex + +17 +00:01:23,200 --> 00:01:30,580 +gene أو HLA أو human leukocyte antigen and they are + +18 +00:01:30,580 --> 00:01:35,940 +recognized in a region encoded three classes of + +19 +00:01:35,940 --> 00:01:41,040 +molecule ثلاثة أنواع من ال MLC موجودة وهي تحت في ال + +20 +00:01:41,040 --> 00:01:47,270 +human في عندنا three regions الأولى بيسموها region + +21 +00:01:47,270 --> 00:01:57,470 +number A ثم B ثم C وهدول الثلاث لـ class 1 ثم ال + +22 +00:01:57,470 --> 00:02:02,490 +region D هي لـ class 2 يبقى في عندنا ثلاثة أنواع من + +23 +00:02:02,490 --> 00:02:08,370 +MHC class molecule اللي هو class 1 و class 2 و + +24 +00:02:08,370 --> 00:02:15,400 +class 3 موجودين على كروموسوم رقم ستة في موزعين في + +25 +00:02:15,400 --> 00:02:21,260 +أربع مناطق أربع four different regions دي ABC ثم D + +26 +00:02:21,260 --> 00:02:27,720 +يتوسطهم class ثلاثة و for unknown reason for + +27 +00:02:27,720 --> 00:02:33,340 +unknown reason هالكروموسوم رقم ستة على الشورت آرم + +28 +00:02:33,340 --> 00:02:40,220 +كروموسوم رقم ستة اسمها HLA region وهي مقسمة إلى ثلاثة + +29 +00:02:40,220 --> 00:02:45,660 +ثلاثة different types of genes class واحد class + +30 +00:02:45,660 --> 00:02:50,160 +اثنين class ثلاثة طبعًا زي ما أنتم شايفين في عندنا + +31 +00:02:50,160 --> 00:02:55,580 +gene وفي صامت جين إنما كلهم احنا مهتمين بالـ + +32 +00:02:55,580 --> 00:02:56,560 +functional gene + +33 +00:03:00,220 --> 00:03:04,540 +وهذه طبعًا صورة بتبين لي بوضوح تركيبة كل واحد منهم + +34 +00:03:04,540 --> 00:03:13,120 +هي الـ A class 1 ABC بيتكون من alpha-polypeptide + +35 +00:03:13,120 --> 00:03:21,760 +linked with B2-microglobulin protein كون لي اللي + +36 +00:03:21,760 --> 00:03:31,750 +هو الـ MHC او الـ HLA رقم A هو ده بيتكون من ثلاثة + +37 +00:03:31,750 --> 00:03:36,050 +domain لـ Alpha مع بيتا2-Microglobulin كل واحد من + +38 +00:03:36,050 --> 00:03:43,850 +هدول اللي هو نفس التركيبة بينما class 2 بيتكون من + +39 +00:03:43,850 --> 00:03:53,250 +DR, DQ و DB ماشي وكل واحد منهم بيتكون من two + +40 +00:03:53,250 --> 00:04:00,380 +polypeptide A to region طبعًا A و B اللي فيها two + +41 +00:04:00,380 --> 00:04:03,580 +polypeptide Alpha و Beta واللي بيكونولي في + +42 +00:04:03,580 --> 00:04:10,080 +النهاية الـDR والـDQ والـDB طبعًا الـ Alpha والـ Beta + +43 +00:04:10,080 --> 00:04:14,860 +chain كل واحدة منهم زي ما أنتم شايفين تتكون من + +44 +00:04:14,860 --> 00:04:20,860 +two domain Alpha 1 و Alpha 2 و Beta 1 و Beta 2 and + +45 +00:04:20,860 --> 00:04:25,000 +they configure in a shape resembling أو الـ + +46 +00:04:25,000 --> 00:04:29,820 +Immunoglobulin Structure هذا هو نفس الحكاية لأن + +47 +00:04:29,820 --> 00:04:32,900 +كلهم يندرجوا تحت الـ Immunoglobulin Gen + +48 +00:04:32,900 --> 00:04:38,480 +Superfamily Class I MHC Molecule هو Media Immune + +49 +00:04:38,480 --> 00:04:41,600 +Response ضد الاندوجينس وظيفته يتعرف على + +50 +00:04:41,600 --> 00:04:47,320 +الاندوجينس انتجن اللي موجود في الخلايا + +51 +00:05:02,430 --> 00:05:06,870 +الخلايا اللي بيصير فيها طبعًا هذه الانتجينات + +52 +00:05:06,870 --> 00:05:16,880 +الداخلية اندوجينس اما viral او tumor antigen الـ + +53 +00:05:16,880 --> 00:05:22,660 +MHC موليكول بيرتبط بـ Antigenic Peptide حجمها 8 + +54 +00:05:22,660 --> 00:05:27,860 +إلى 10 Amino Acids اللي بعد هيك تتقدم للـ + +55 +00:05:27,860 --> 00:05:34,230 +Cytotoxic T Lymphocyte اللي هي CD8 ووجدوا ان الـ MHC + +56 +00:05:34,230 --> 00:05:38,150 +class 1 موجود على كل خلايا الجسم وبالتالي أي خلية + +57 +00:05:38,150 --> 00:05:43,310 +بيصير فيها infection سواء virally او tumor تستطيع + +58 +00:05:43,310 --> 00:05:47,530 +أن تقدم الانتجين للساعة الـ Cytotoxic T Lymphocyte تخلصنا + +59 +00:05:47,530 --> 00:05:54,270 +منه الـ class 2 بيبقى Immune response against + +60 +00:05:54,270 --> 00:05:57,930 +exogenous انتجين الانتجينات القارجية اللي موجودين + +61 +00:05:57,930 --> 00:06:05,720 +برا الخلية و Class II يرتبط بـ Peptide حجمها 13 لـ + +62 +00:06:05,720 --> 00:06:10,580 +18 Amino Acids in size that are presented to T + +63 +00:06:10,580 --> 00:06:15,420 +-Helper cell and recognized by it الـ MHC Class II + +64 +00:06:15,420 --> 00:06:19,860 +موجود على خلايا محددة مش على كل خلايا الجسم موجود + +65 +00:06:19,860 --> 00:06:23,580 +على الـ B-Lymphocytes على الـ Macrophage على الـ + +66 +00:06:23,580 --> 00:06:27,140 +Monocyte, Dendritic Cell و Endothelial Cells وإذا + +67 +00:06:27,140 --> 00:06:31,600 +لاحظنا ان هذه الخلايا هي عبارة عن Antigen + +68 +00:06:31,600 --> 00:06:38,060 +Presenting Cell هذول فجوسيتيك ويمكن انه يدخل + +69 +00:06:38,060 --> 00:06:42,900 +بسهولة الـ Extracellular Antigen Class III زي ما + +70 +00:06:42,900 --> 00:06:49,320 +قلنا لكم ليس لديه رول في الانتجين برزنتيشن لكنه + +71 +00:06:49,320 --> 00:06:52,200 +يتكون لسكرت البروتين + +72 +00:06:56,360 --> 00:07:01,160 +من خلال البروسيس الدينية وجوده ما بين class 1 و + +73 +00:07:01,160 --> 00:07:06,800 +class 2 هو غير متأكد بمعنى مش معروف او مش مؤكد + +74 +00:07:06,800 --> 00:07:11,020 +لما + +75 +00:07:11,020 --> 00:07:18,160 +تشوف هبلو تايب جاله كل ستة جينات موجودة على نفس + +76 +00:07:18,160 --> 00:07:24,510 +الكروموسوم ماشي set of genes بيسموها haplotype يبقى + +77 +00:07:24,510 --> 00:07:28,990 +الـ haplotype هي عبارة عن set of gene لـ class واحد و + +78 +00:07:28,990 --> 00:07:32,070 +set of gene لـ class اثنين مرتبطين على one + +79 +00:07:32,070 --> 00:07:35,530 +chromosome موجودين على chromosome واحد اللي هو رقم + +80 +00:07:35,530 --> 00:07:41,610 +ستة وكلهم collectively are known as haplotype و + +81 +00:07:41,610 --> 00:07:44,550 +الـ individual عنده two haplotype واحد جاي من الـ + +82 +00:07:44,550 --> 00:07:49,350 +maternal واحد جاي من الـ paternal وهذه الجينات + +83 +00:07:49,350 --> 00:07:56,530 +موصولة مع بعض يعني يورثوا مع بعض مادياً ومادياً + +84 +00:07:56,530 --> 00:08:04,810 +برودكت موصولة في نفس الجسيم.الكلاس وان الستركترات + +85 +00:08:04,810 --> 00:08:09,770 +التي اتفقنا بها تكوين من الفا، عبارة عن عبارة عن + +86 +00:08:09,770 --> 00:08:14,770 +عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن الـ + +87 +00:08:14,770 --> 00:08:17,170 +Alpha هي عبارة عن Polymorphic Transmembraic + +88 +00:08:17,170 --> 00:08:22,510 +Glycoprotein بيتكون من three domain بيتكون من 3 + +89 +00:08:22,510 --> 00:08:27,250 +three domain Alpha 1, Alpha 2, Alpha 3 مرتبطة بالـ + +90 +00:08:27,250 --> 00:08:30,970 +Beta 2-microglobulin وعبارة عن invariant protein + +91 +00:08:30,970 --> 00:08:38,670 +encoded by a gene on a different chromosome طبعًا الـ + +92 +00:08:38,670 --> 00:08:44,110 +association بين Alpha و Beta 2 microglobulin مطلوب + +93 +00:08:44,110 --> 00:08:50,810 +جدا for the expression class I on cell membrane و + +94 +00:08:50,810 --> 00:08:56,730 +ده هو أي Alpha بيتكون من ثلاثة دومين Alpha 1 Alpha + +95 +00:08:56,730 --> 00:09:02,370 +2 Alpha 3 مرتبطة بـ Beta 2 microglobulin الجزء + +96 +00:09:02,370 --> 00:09:08,030 +البراني اللي هو extra cellular ده هو براني three + +97 +00:09:08,030 --> 00:09:14,210 +اللي هو عبارة عن invariant chains بمعنى هي عبارة + +98 +00:09:14,210 --> 00:09:22,250 +عن variable و الـ peptide بيرتبط في هذه المنطقة + +99 +00:09:22,250 --> 00:09:29,220 +باسمها peptide cleft او peptide binding growth ماشي + +100 +00:09:29,220 --> 00:09:35,100 +Alpha 3 و Beta 2 microglobulin are constant region + +101 +00:09:35,100 --> 00:09:44,680 +و CD8 بيرتبط غالبا بالـ Alpha 3 بيرتبط بالـ Alpha 3 + +102 +00:09:44,680 --> 00:09:50,440 +الـ molecule أيضا فيه Trans membrane و فيه short + +103 +00:09:50,440 --> 00:09:56,950 +cytoplasmic tail structure collectively زي ما أنتم + +104 +00:09:56,950 --> 00:10:06,010 +شايفين resembling immunoglobulin in shape and even + +105 +00:10:06,010 --> 00:10:11,850 +structure بينما الـ class two structure بتتكون من + +106 +00:10:11,850 --> 00:10:15,770 +two polypeptide واحدة Alpha واحدة Beta وكل واحدة + +107 +00:10:15,770 --> 00:10:19,430 +بتتكون من two domain Alpha one Alpha two و Beta one + +108 +00:10:19,430 --> 00:10:26,230 +و Beta two أيضًا الـ antigen binding موجود بين الفا + +109 +00:10:26,230 --> 00:10:31,110 +واحد وبيتا واحد مرانو كما تشاهدون الانتجينيك + +110 +00:10:31,110 --> 00:10:37,550 +بيبتايد شويه اكبر وبالتالي بيستطي بعاد شويه عن بعض + +111 +00:10:37,550 --> 00:10:45,470 +بالتالي بيرتبطوا بانتجينيك بيبتايد شويه اكبر ماشي + +112 +00:10:45,470 --> 00:10:50,070 +أيضًا له Transmembrane and cytoplasmic tail + +113 +00:10:57,020 --> 00:11:00,100 +بالمناسبة Alpha 1 Beta 1 هي عبارة عن الـ Variable + +114 +00:11:00,100 --> 00:11:03,180 +و Alpha 2 Beta 2 هي عبارة عن الـ Constant + +115 +00:11:03,180 --> 00:11:09,380 +وهذا الجدول يظهر الفروقات بين Class 1 و Class 2 + +116 +00:11:09,380 --> 00:11:15,740 +يتكون من Alpha 1 Alpha 2 الى Alpha 1 Beta 1 + +117 +00:11:15,740 --> 00:11:21,320 +لمنطقة الارتباط بالـ Antigen طبعًا هذه المنطقة مسكرة + +118 +00:11:21,320 --> 00:11:26,420 +في class 1 لكنها مفتوحة في class 2 فـ ال size of + +119 +00:11:26,420 --> 00:11:32,860 +peptide 8 شويه صغير لكنها من 13 ل 18 لأنها مفتوحة + +120 +00:11:32,860 --> 00:11:38,520 +و اكبر الـ peptide motif anchor residue at both + +121 +00:11:38,520 --> 00:11:45,040 +ends of peptide and generally hydrophobic carboxyl + +122 +00:11:45,040 --> 00:11:48,750 +terminal اللي بيبقوا طالعين هذه نفس الحكاية Anchor + +123 +00:11:48,750 --> 00:11:52,030 +residue distributed along the length of the + +124 +00:11:52,030 --> 00:11:58,870 +peptide على طول الـ peptide initial and bound هذا + +125 +00:11:58,870 --> 00:12:05,130 +بيرتبط بالانتيجين + +126 +00:12:05,130 --> 00:12:07,230 +يتعامل مع عمق الشق اليسار + +127 +00:12:10,160 --> 00:12:16,280 +وهذا اتسلب at a constant elevation above the floor + +128 +00:12:16,280 --> 00:12:24,880 +of MHC cleft MHC + +129 +00:12:24,880 --> 00:12:29,780 +class 1 per class 2 peptide interaction طبعًا ترتبط + +130 +00:12:29,780 --> 00:12:33,400 +بال peptide and presented to CD4 T-Helper cell and + +131 +00:12:33,400 --> 00:12:38,650 +it can bind to a variety of peptide وبتعمل + +132 +00:12:38,650 --> 00:12:41,930 +Endocytic Processing Pathway نتعرف عليه قدام + +133 +00:12:41,930 --> 00:12:47,710 +Polymorphism of class 1 و2 قالوا الـ polymorphism + +134 +00:12:47,710 --> 00:12:51,450 +هو عبارة عن الـ presence of multiple alleles at a + +135 +00:12:51,450 --> 00:12:57,030 +given genetic locus within a species ووجدوا انه at + +136 +00:12:57,030 --> 00:13:03,110 +class 1 و class 2 there are في هذه المناطق علشان هي + +137 +00:13:03,110 --> 00:13:09,470 +Polymorphic Polymorphic جين Diversity of MHC + +138 +00:13:09,470 --> 00:13:14,350 +within a species results from this polymorphism و + +139 +00:13:14,350 --> 00:13:17,650 +الـ MHC expressed by individual does not change + +140 +00:13:17,650 --> 00:13:22,690 +over the time لكن فيه different significantly + +141 +00:13:22,690 --> 00:13:29,930 +between individuals within the same species بيقول إن + +142 +00:13:29,930 --> 00:13:33,770 +في عشر قوى ناحية theoretical diversity في الميس + +143 +00:13:33,770 --> 00:13:38,530 +من class 1 و class 2 يعني هي من class 1 بيقولوا + +144 +00:13:38,530 --> 00:13:47,010 +class 2 يعني أقل شوية عشر قوى عشرة polymorphism + +145 +00:13:47,010 --> 00:13:53,890 +of class 1 و 8 أيضا this will serve as the antigen الـ + +146 +00:13:53,890 --> 00:13:59,470 +MHC molecule ستعمل كـأنتيجن لكي تسمح للإنسان بمعرفة + +147 +00:13:59,470 --> 00:14:05,070 +ما هو نفسك وما هو غير نفسك مجموعات مختلفة الأليل + +148 +00:14:05,070 --> 00:14:12,050 +تعمل كأن الأنتيجن هو MHC molecule وفي كل جنس هناك + +149 +00:14:12,050 --> 00:14:16,490 +الكثير من الأليلات المهم في هذا الموضوع أن هناك + +150 +00:14:16,490 --> 00:14:21,430 +الكثير من الأليلات وكثير من المجموعات وبالتالي لا + +151 +00:14:21,430 --> 00:14:22,190 +يمكن أن يكون هناك + +152 +00:14:28,320 --> 00:14:33,060 +لكن عملية الـ transplantation ليست مستحيلة اليوم يوجد + +153 +00:14:33,060 --> 00:14:39,360 +آلاف عمليات من عمليات transplantation كل عام ونتطلع + +154 +00:14:39,360 --> 00:14:45,920 +لهذا الموضوع في عرض transplantation Class III هم + +155 +00:14:45,920 --> 00:14:48,160 +مجموعات مختلفة ومستقلة ومفتوحة ومستقلة ومستقلة + +156 +00:14:48,160 --> 00:14:48,980 +ومستقلة ومستقلة ومستقلة ومستقلة ومستقلة + +157 +00:14:48,980 --> 00:14:50,360 +ومستقلة ومستقلة ومستقلة ومستقلة ومستقلة + +158 +00:14:50,360 --> 00:14:51,000 +ومستقلة ومستقلة ومستقلة ومستقلة ومستقلة + +159 +00:14:51,000 --> 00:14:51,220 +ومستقلة ومستقلة ومستقلة ومستقلة ومستقلة + +160 +00:14:51,220 --> 00:14:56,570 +ومستقلة ومستقلة ومستقلة وهم يحتوي على مجموعات + +161 +00:14:56,570 --> 00:14:59,810 +متشابهة مختلفة مثل الـ Human Necrosis Factor أو + +162 +00:14:59,810 --> 00:15:01,230 +الـ Heat Shock Protein أو الـ Heat Shock Protein + +163 +00:15:01,230 --> 00:15:02,130 +أو الـ Heat Shock Protein أو الـ Heat Shock + +164 +00:15:02,130 --> 00:15:06,310 +Protein أو الـ Heat + +165 +00:15:06,310 --> 00:15:06,430 +Shock Protein أو الـ Heat Shock Protein أو الـ + +166 +00:15:06,430 --> 00:15:08,810 +Heat Shock Protein أو الـ Heat Shock Protein أو + +167 +00:15:08,810 --> 00:15:12,010 +الـ Heat Shock Protein أو الـ Heat Shock Protein + +168 +00:15:12,010 --> 00:15:12,070 +أو الـ Heat Shock Protein أو الـ Heat Shock + +169 +00:15:12,070 --> 00:15:12,090 +الـ Heat Shock Protein أو الـ Heat Shock Protein + +170 +00:15:12,090 --> 00:15:12,870 +Protein أو الـ Heat Shock Protein أو الـ Heat + +171 +00:15:12,870 --> 00:15:16,370 +Shock Protein أو الـ Heat Shock Protein أو الـ + +172 +00:15:16,370 --> 00:15:21,610 +Heat Shock Protein أو الـ Heat Shock + +173 +00:15:21,610 --> 00:15:23,910 +Protein أو الـ Heat Shock Protein أو الـ Heat + +174 +00:15:23,910 --> 00:15:27,710 +Shock Protein هيلي كونزيرف دي بروتين بينوجد فيه فيه + +175 +00:15:27,710 --> 00:15:36,650 +أوقات غير طبيعية وفي محفزات كثيرة لإنتاج ذو سيد شك + +176 +00:15:36,650 --> 00:15:41,830 +بروتين ماشي منها على سبيل المثال الـ nutrient + +177 +00:15:41,830 --> 00:15:45,930 +deprivation مجاعات أكسجين راديكال and viral + +178 +00:15:45,930 --> 00:15:52,410 +infection كل عبارة عن محفزات لخيكشك بروتين + +179 +00:15:52,410 --> 00:15:56,010 +production وهي مرتبطة بشكل عام بشكل عام بشكل عام + +180 +00:15:56,010 --> 00:15:58,170 +بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل + +181 +00:15:58,170 --> 00:16:01,070 +عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام + +182 +00:16:01,070 --> 00:16:02,850 +بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل + +183 +00:16:02,850 --> 00:16:03,930 +عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام + +184 +00:16:03,930 --> 00:16:04,770 +بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل + +185 +00:16:04,770 --> 00:16:08,050 +عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام + +186 +00:16:08,050 --> 00:16:12,920 +عام بشكل عام بـ processing and presentation هذه + +187 +00:16:12,920 --> 00:16:16,040 +مصطلحين عندنا الـ processing هي عبارة عن عملية + +188 +00:16:16,040 --> 00:16:21,960 +تجهيز وتشجيف وتقطيع الـ antigen ماشي بسموها + +189 +00:16:21,960 --> 00:16:25,800 +processing والـ presentation هي عبارة عن عملية + +190 +00:16:25,800 --> 00:16:29,180 +تقديم الـ antigen بيرتبط من MSH molecule على سطح + +191 +00:16:29,180 --> 00:16:34,680 +الخلية و بيتقدم لمين؟ لـ T cell يبقى الـ processing + +192 +00:16:34,680 --> 00:16:39,730 +هو عبارة عن عملية ايهاش الـ degradation of antigen + +193 +00:16:39,730 --> 00:16:47,330 +into peptide والـ presentation هو عبارة عن تقديم + +194 +00:16:47,330 --> 00:16:55,910 +هذا الـ antigen لـ T cell الـ class I بيرتبط موليكوله + +195 +00:16:55,910 --> 00:16:59,530 +طبعا معيشي موليكوله بايد بيبتايد derived from + +196 +00:16:59,530 --> 00:17:00,250 +endogenous + +197 +00:17:03,260 --> 00:17:06,260 +هذا الأنتيجن الـ endogenous يمكن أن يتم تصميمه في + +198 +00:17:06,260 --> 00:17:10,440 +الإنسان والسايتوبلازم بينما الـ class 2 يرتبط بأنتيجن + +199 +00:17:10,440 --> 00:17:15,180 +إكسوجيني يعني جاية من برا انتيجنيا بفاجوسيتوسيا أو + +200 +00:17:15,180 --> 00:17:19,880 +إندوسيتوسيا بسرعة التصميم الإندوسيتيكي التي + +201 +00:17:19,880 --> 00:17:25,430 +سنشاهدها الآن بما أننا ندخل في عملية الـ Processing + +202 +00:17:25,430 --> 00:17:28,950 +والـ Presentation نريد أن نؤكد على عملية الـ MHC + +203 +00:17:28,950 --> 00:17:32,450 +أو Self-MHC Restriction بمعنى أن الـ T-Lymphocyte + +204 +00:17:32,450 --> 00:17:38,190 +لا تتعامل إلا مع MHC molecule شافته قبل هيك within + +205 +00:17:38,190 --> 00:17:42,210 +the same species وين؟ في الـ Thymus مش بتقدم لها وهي + +206 +00:17:42,210 --> 00:17:48,150 +بتتعلم وبتتدرب وبالتالي ما بتتعامل مع MHC from + +207 +00:17:48,150 --> 00:17:51,390 +other individuals + +208 +00:17:53,210 --> 00:17:59,430 +طبعا في اثنين علماء هم زي انجرنيجل ودوارتي + +209 +00:17:59,430 --> 00:18:07,290 +عملوا تجربة ليسببوا تقول ذلك فراحوا ايش عملوا؟ ده هي + +210 +00:18:07,290 --> 00:18:13,490 +طبعا دي اللي هو التجربة خلينا نشوفها ده هو جابوا + +211 +00:18:13,490 --> 00:18:22,010 +فار وحقنوه بـ الـ CM الـ virus اللي هو الـ + +212 +00:18:24,930 --> 00:18:33,730 +Lymphocyte Chorium meningitis virus وبعد + +213 +00:18:33,730 --> 00:18:39,770 +أسبوعين أخذوا خلايا من الـ Spleen هذه الخلايا تحتوي + +214 +00:18:39,770 --> 00:18:48,170 +على T-cytotoxic وهي بتكون Alliard يعني جاهزة للتأ + +215 +00:18:48,170 --> 00:18:55,400 +للقتل ثم عملوا incubation لهذه الخلايا مع target + +216 +00:18:55,400 --> 00:19:06,600 +cell من اللي هو نفس الفار لكن هو مش infected ومع + +217 +00:19:06,600 --> 00:19:11,720 +نفس الفار لكن الخلايا تبعته infected ومع فار من + +218 +00:19:11,720 --> 00:19:18,520 +نوع ثاني وطبعا الـ antigen is already labeled by + +219 +00:19:18,520 --> 00:19:24,400 +group وطلعوا على النتيجة وجهوا أن في الـ not + +220 +00:19:24,400 --> 00:19:29,940 +infected cell ما صللهاش حاجة والـ infected cell من + +221 +00:19:29,940 --> 00:19:35,840 +نفس الفار اي 2K H2K وهي الفار H2K من نفس الفار + +222 +00:19:35,840 --> 00:19:41,680 +صللها license بينما اللي اجت من الفار ثاني هي 2B + +223 +00:19:41,680 --> 00:19:45,200 +there is no license بمعنى لم تتعرف عليها ولم + +224 +00:19:45,200 --> 00:19:55,520 +تعجبها ماشي يعني لو حطيناها في part تاني لن + +225 +00:19:55,520 --> 00:19:59,520 +تترف على اللي هو الأمشي molecule تبعها + +226 +00:20:02,540 --> 00:20:06,740 +الـ Self-restriction طبعا لـ CD4 و CD8 احنا قلنا + +227 +00:20:06,740 --> 00:20:16,640 +لجيتها لـ CT cytotoxic خدنا نشوف تجربة عندهم لـ CD4 + +228 +00:20:16,640 --> 00:20:21,900 +طبعا جابوا two strain لكن الـ strain هدول هجين + +229 +00:20:21,900 --> 00:20:31,520 +ماشي من الخنازير Strain 2 و 13 واحد Strain 2 و 13 + +230 +00:20:32,110 --> 00:20:36,570 +عرضوا لواحد اعطوا واحد antigen واستنوا سبعة أيام + +231 +00:20:36,570 --> 00:20:41,210 +وراحوا على الانفنوس لو بوها كبرت فاخدوا منها الـ + +232 +00:20:41,210 --> 00:20:45,270 +macrophage فدل حالة الـ macrophage هي عبارة عن الـ + +233 +00:20:45,270 --> 00:20:49,130 +yard cell هتاخد الـ antigen هتاخد الـ antigen + +234 +00:20:49,130 --> 00:20:53,330 +المجموعة + +235 +00:20:53,330 --> 00:20:58,930 +الثانية اللي هي برضه نفس أنواع الـ strains أخدتوا + +236 +00:20:58,930 --> 00:21:00,690 +من الـ peritoneal exudate cell + +237 +00:21:03,940 --> 00:21:13,880 +وعملوها طبعا اديرانس في petri dish وبعد ذلك أخذوا + +238 +00:21:13,880 --> 00:21:18,180 +الـ peritoneal macrophage وعرضوها لـ antigen + +239 +00:21:18,180 --> 00:21:24,620 +وبالتالي صارت antigen presenting cell يبقى هنا هي + +240 +00:21:24,620 --> 00:21:29,380 +برهان خلية أخذوا T lymphocyte من هنا sorry antigen + +241 +00:21:29,380 --> 00:21:30,280 +primed T cell + +242 +00:21:33,180 --> 00:21:39,860 +أخذوا الـ T lymphocytes من الـ lymph nodes اللي هي + +243 +00:21:39,860 --> 00:21:44,440 +CD4 وهنا حضروا اللي هو الـ antigen presenting cell + +244 +00:21:44,440 --> 00:21:49,380 +والثانيين حضروهم يعني they add to each other all + +245 +00:21:49,380 --> 00:21:55,960 +of them and they culture media طبعا النتائج قالوا + +246 +00:21:55,960 --> 00:21:59,580 +لما حطينا Strain 2 + +247 +00:22:02,290 --> 00:22:08,950 +T Cell من Strain 2 مع Antigen Presenting Cell من + +248 +00:22:08,950 --> 00:22:14,070 +Strain 2 صار فيه تفاعل ايه؟ وزاد لكن لما صار لما + +249 +00:22:14,070 --> 00:22:19,850 +حطناها مع Strain 13 ما صار ولما حطناها مع الهجين + +250 +00:22:19,850 --> 00:22:28,950 +اللي هو 8 و 13 صار نفس الحكاية بالنسبة لـ 13 مع + +251 +00:22:28,950 --> 00:22:34,230 +Strain 2 ما صار تفاعل مع Strain 13 صار مع الهجين + +252 +00:22:34,230 --> 00:22:40,870 +أيضا صار Strain الهجين ده هو اللي لما حطينا الخلية + +253 +00:22:40,870 --> 00:22:45,730 +الهجين T-Lymphocyte من الـ Strain الهجين حطيناها مع + +254 +00:22:45,730 --> 00:22:55,740 +Strain 2 و Strain 13 و Strain ولا جين كلها ماتت + +255 +00:22:55,740 --> 00:23:01,460 +اللي هو التفاعل دليل على أن الـ antigen present أو + +256 +00:23:01,460 --> 00:23:05,700 +الـ T-lymphocyte لها تتعرف على انتيجن مرتبط بـ MSC + +257 +00:23:05,700 --> 00:23:10,180 +molecule from the same species + +258 +00:23:10,180 --> 00:23:15,630 +from the same individual of the same species طيب + +259 +00:23:15,630 --> 00:23:18,850 +أنتيجن presenting cell يعني انتيجن presenting cell + +260 +00:23:18,850 --> 00:23:22,870 +زي ما اتفقنا هي أما الـ C class واحد موجود على كل + +261 +00:23:22,870 --> 00:23:25,990 +خلايا الجسم ويوم تصير infected بيسموها target cell + +262 +00:23:25,990 --> 00:23:31,310 +بينما أما الـ C class 2 موجود على ايش؟ على certain + +263 +00:23:31,310 --> 00:23:31,830 +cells + +264 +00:23:34,680 --> 00:23:40,000 +وقسمهم إلى الـ Antigen Presenting Cell وقسم مشكلة + +265 +00:23:40,000 --> 00:23:44,120 +خلايا الجسم وقسمهم إلى نوعين Professional Antigen + +266 +00:23:44,120 --> 00:23:46,060 +Presenting Cell وهي عبارة عن الـ Dendritic Cell + +267 +00:23:46,060 --> 00:23:49,320 +و Macrophage B Cell و Non Professional باقي الخلايا + +268 +00:23:49,320 --> 00:23:51,980 +اللي احنا حكينا عنها زي الـ Fibroblast, Glial و + +269 +00:23:51,980 --> 00:23:58,300 +Pancreatic Cell اللي موجودة في أماكن مختلفة الـ + +270 +00:23:58,300 --> 00:24:01,080 +processing زي ما قلنا في عندنا الـ extracellular + +271 +00:24:01,080 --> 00:24:02,140 +أو الـ extragenous + +272 +00:24:14,230 --> 00:24:17,270 +أنتيجن انتيجن انتيجن انتيجن انتيجن انتيجن انتيجن انتيجن + +273 +00:24:17,270 --> 00:24:17,630 +أنتيجن انتيجن انتيجن انتيجن انتيجن انتيجن انتيجن انتيجن + +274 +00:24:17,630 --> 00:24:18,950 +أنتيجن انتيجن انتيجن انتيجن انتيجن انتيجن انتيجن انتيجن + +275 +00:24:18,950 --> 00:24:21,810 +أنتيجن انتيجن انتيجن انتيجن انتيجن انتيجن انتيجن انتيجن + +276 +00:24:21,810 --> 00:24:22,570 +أنتيجن انتيجن انتيجن انتيجن انتيجن انتيجن انتيجن انتيجن + +277 +00:24:22,570 --> 00:24:23,210 +أنتيجن انتيجن انتيجن انتيجن انتيجن انتيجن انتيجن انتيجن + +278 +00:24:34,250 --> 00:24:37,150 +الأنتيجن برزانتيج سيل بتاخد الانتيجن أما by + +279 +00:24:37,150 --> 00:24:44,030 +phagocytosis أو endocytosis متى ما أخدت الانتيجن + +280 +00:24:44,030 --> 00:24:47,150 +طبعا الـ micro facial بتاع مابتشتغل بجهتين لكن + +281 +00:24:47,150 --> 00:24:53,110 +بيأخذ الانتيجن by endocytosis بيخش + +282 +00:24:53,110 --> 00:24:58,380 +الانتيجن جوا بيبدأ يصير له degradation طبعاً + +283 +00:24:58,380 --> 00:25:02,400 +عملية تأخذ عامة من ساعة إلى ثلاث ساعات + +284 +00:25:02,400 --> 00:25:07,360 +عشان يكتمل ويطلع الـ MHC molecule مرتبط بالـ class + +285 +00:25:07,360 --> 00:25:12,600 +2 MHC molecule مرتبط بالانتيجن الـ internalized + +286 +00:25:12,600 --> 00:25:18,540 +antigen ده هي الحكاية وببساطة هي مشروحة فهي الـ + +287 +00:25:18,540 --> 00:25:25,640 +antigen طبعاً مرتبطة ده هو بالـ receptor دخل هو + +288 +00:25:25,640 --> 00:25:29,030 +عبارة عن antibody في vesicle بيسموها clathrin + +289 +00:25:29,030 --> 00:25:36,150 +-coated vesicle في الـ .. في هذه الـ vesicle ماشي + +290 +00:25:36,150 --> 00:25:44,270 +بيصير في sudden drop للـ .. اللي هو للـ pH فبيصير في + +291 +00:25:44,270 --> 00:25:50,270 +release .. release للانتيجن وفصل اللي هو الـ + +292 +00:25:50,270 --> 00:25:53,870 +receptor اللي برجع تاني الـ receptor مرة تانية على + +293 +00:25:53,870 --> 00:25:59,010 +الـ surface بينما الـ antigen صار في داخل الـ vesicle + +294 +00:25:59,010 --> 00:26:04,110 +الـ vesicle ها دي بيتمر في عدة أدوار بعتبروها اللي + +295 +00:26:04,110 --> 00:26:08,910 +هو early endosome ثم بتنتقل إلى مرحلة ثانية اللي + +296 +00:26:08,910 --> 00:26:10,670 +هي عبارة عن late endosome + +297 +00:26:13,090 --> 00:26:18,190 +ماشي في الـ endoplasmic reticulum في مكان آخر من + +298 +00:26:18,190 --> 00:26:23,190 +الخلية بيتم تصنيع اللي هو الـ MHC molecule بيتصنع + +299 +00:26:23,190 --> 00:26:27,190 +بيروح الجولجي أبراطس بيطلع من الجولجي أبراطس + +300 +00:26:27,190 --> 00:26:30,870 +انها vesicle و أثناء عركة الخلية two vesicle + +301 +00:26:30,870 --> 00:26:35,710 +fused together و بيكونوا one vesicle فبيصير الـ + +302 +00:26:35,710 --> 00:26:39,930 +vesicle اللي متكونت هي عبارة عن vesicle فيها MHC + +303 +00:26:39,930 --> 00:26:48,860 +molecule وانتيجن طبعاً في هذه الحالة الـ lysosome + +304 +00:26:48,860 --> 00:26:51,800 +يدخل ويعمل degradation ويشجف على الـ sugar في صغيرة + +305 +00:26:51,800 --> 00:26:59,600 +ويشجف على الـ sugar + +306 +00:26:59,600 --> 00:27:02,200 +في صغيرة ويشجف على الـ sugar في صغيرة ويشجف على الـ + +307 +00:27:02,200 --> 00:27:03,220 +sugar في صغيرة ويشجف على الـ sugar في صغيرة ويشجف + +308 +00:27:03,220 --> 00:27:04,200 +ويشجف على الـ sugar في صغيرة ويشجف على الـ sugar في + +309 +00:27:04,200 --> 00:27:04,280 +صغيرة ويشجف على الـ sugar في صغيرة ويشجف على الـ + +310 +00:27:04,280 --> 00:27:04,920 +sugar في صغيرة ويشجف على الـ sugar في صغيرة ويشجف + +311 +00:27:04,920 --> 00:27:06,340 +على الـ sugar في صغيرة ويشجف على الـ sugar في صغيرة + +312 +00:27:06,340 --> 00:27:07,120 +ويشجف على الـ sugar في صغيرة ويشجف على الـ sugar في + +313 +00:27:07,120 --> 00:27:11,400 +صغيرة ويشجف على الـ sugar + +314 +00:27:15,340 --> 00:27:21,100 +هذه العملية مرة ثانية واضحة بكتيريا دخلت خدناها + +315 +00:27:21,100 --> 00:27:28,120 +باي اللي هو by endocytosis اتكونت vesicle دخلت + +316 +00:27:28,120 --> 00:27:32,460 +فيها الـ lysosome كسرتها في مكان آخر من الخلية بتصنع + +317 +00:27:32,460 --> 00:27:37,240 +الـ endoplasmic molecule بيروح بعد هي كترين + +318 +00:27:37,240 --> 00:27:41,900 +بيرتبط ويطلع برا هو في رحلة على الـ cell membrane + +319 +00:27:41,900 --> 00:27:44,020 +ان الـ endoplasmic molecule بيطلع على الـ cell + +320 +00:27:44,020 --> 00:27:49,020 +membrane ماشي فبيطلع هو في رحلته بيطلع في vesicle + +321 +00:27:49,020 --> 00:27:52,420 +بضرب في الـ vesicle التاني وبيكونوا vesicle + +322 +00:27:52,420 --> 00:27:56,620 +واحدة ده هي بيسموها phagolysosome وطبعاً بيصير + +323 +00:27:56,620 --> 00:28:02,700 +عملية degradation ل اللي هو الـ antigenic peptides + +324 +00:28:02,700 --> 00:28:08,480 +peptide وبتنتبط محل الـ peptide البديلة اللي كانت + +325 +00:28:08,480 --> 00:28:11,640 +طالعة بالامر الـ MHC molecule وما بيطلع مرتبط بالـ + +326 +00:28:11,640 --> 00:28:13,120 +antigen ده هو السلمة + +327 +00:28:17,000 --> 00:28:21,780 +هذا الـ exogenous وطوى شرحناه الاندوجينوس يعني + +328 +00:28:21,780 --> 00:28:26,280 +الانتيجن في داخل الخلية في داخل الخلية ده هو + +329 +00:28:26,280 --> 00:28:31,980 +الانتيجن اندوجينوس انتيجن بيصير له degradation by + +330 +00:28:31,980 --> 00:28:36,120 +proteasome هو فيه في الخلايا already proteasome + +331 +00:28:36,120 --> 00:28:43,920 +بمقاسات مختلفة المهم الانتيجن بيصير له degradation وبعد + +332 +00:28:43,920 --> 00:28:50,000 +ذلك الـ Endogenous Antigen يدخل على الـ + +333 +00:28:50,000 --> 00:28:56,920 +Endoplasmic reticulum من خلال TAP protein TAP + +334 +00:28:56,920 --> 00:29:01,880 +اختصار لـ Transporter Associated Protein + +335 +00:29:04,190 --> 00:29:06,470 +فبيخشوا على الـ endoplasmic reticulum واحنا + +336 +00:29:06,470 --> 00:29:09,490 +عارفين ان في الـ endoplasmic reticulum بيتصنع الـ + +337 +00:29:09,490 --> 00:29:13,650 +MHC class I molecule فهو بيتصنع already على طول + +338 +00:29:13,650 --> 00:29:17,550 +بيصير فيه عملية binding للـ antigen بيرتبط بالـ MHC + +339 +00:29:17,550 --> 00:29:20,890 +molecule فبيوضع على الـ surface بعدها بيطلع برا + +340 +00:29:20,890 --> 00:29:26,530 +وينتقل على الـ cell membrane مرتبط بالـ MHC molecule + +341 +00:29:26,530 --> 00:29:29,750 +الـ + +342 +00:29:29,750 --> 00:29:33,730 +Endogenous بنبدأ بشريحة الكلام اللي بتتواجد هنا بشريحة + +343 +00:29:33,730 --> 00:29:36,630 +الكلام اللي بتتواجد هنا بشريحة الكلام اللي بتتواجد + +344 +00:29:36,630 --> 00:29:40,110 +هنا بشريحة الكلام اللي بتتواجد هنا بشريحة الكلام اللي + +345 +00:29:40,110 --> 00:29:41,890 +بتتواجد هنا بشريحة الكلام اللي بتتواجد هنا بشريحة + +346 +00:29:41,890 --> 00:29:42,670 +الكلام اللي بتتواجد هنا بشريحة الكلام اللي بتتواجد + +347 +00:29:42,670 --> 00:29:44,330 +هنا بشريحة الكلام اللي بتتواجد هنا بشريحة الكلام اللي + +348 +00:29:44,330 --> 00:29:46,130 +بتتواجد هنا بشريحة الكلام اللي بتتواجد هنا بشريحة + +349 +00:29:46,130 --> 00:29:53,910 +الكلام اللي بتتواجد هنا بشريحة الكلام اللي بتتواجد + +350 +00:29:53,910 --> 00:29:58,550 +هنا بشريحة الكلام اللي بتتواجد هنا بشريحة الكلام اللي + +351 +00:29:58,550 --> 00:30:03,830 +Cytosolic نفس الحكاية بس كل ما هنالك ان الاندوجينوس + +352 +00:30:03,830 --> 00:30:08,450 +انتيجن بيصير له labeling بيصير له ubiquitination + +353 +00:30:08,450 --> 00:30:15,310 +بيصير ubiquitin مرتبط بالبروتين الـ conjugate ده هو + +354 +00:30:15,770 --> 00:30:20,850 +بتعرف عليه البروتيوزوم هو بيشكفه إلى قطع صغيرة + +355 +00:30:20,850 --> 00:30:26,590 +بيسموها low molecular mass polypeptide هذا هو + +356 +00:30:26,590 --> 00:30:31,490 +cytosolic هي الـ endogenous antigen بيهيء برا عن + +357 +00:30:31,490 --> 00:30:35,250 +active process بيعيب الـ ubiquitination هذا هو بتحول + +358 +00:30:35,250 --> 00:30:39,210 +إلى labelled بيتعرف عليه البروتيوزوم بشكفه + +359 +00:30:39,210 --> 00:30:43,750 +البيببتايد ثم بعد ذلك بيخش داخل الاندوبلازمي + +360 +00:30:43,750 --> 00:30:48,690 +ريتيكولام من خلال TAP البروتين اللي بيرتبط بـ MHC class I + +361 +00:30:48,690 --> 00:30:53,230 +molecule الاندوسايتيك هو اكسوجينوس انتيجين + +362 +00:30:53,230 --> 00:30:57,410 +بيصير له endocytosis أو phagocytosis وهو طبعاً بيخش + +363 +00:30:57,410 --> 00:31:01,830 +على الاندوسايتيك compartment وهو بتحول البيببتايد + +364 +00:31:02,420 --> 00:31:07,320 +هذه الـ peptide طبعاً بتطلع مرتبطة بالـ MHC class II + +365 +00:31:07,320 --> 00:31:13,420 +molecule طبعاً الـ lysosome هي عبارة عن protein + +366 +00:31:13,420 --> 00:31:17,520 +بتتحلل الـ amino acids اللي بيروح على اللي هو الـ + +367 +00:31:17,520 --> 00:31:25,550 +amino acid الخلية هذا هو البروتيوزوم البروتيوليتيك + +368 +00:31:25,550 --> 00:31:36,590 +الانزيم البروتيوليتيك + +369 +00:31:36,590 --> 00:31:36,730 +البروتيوليتيك البروتيوليتيك البروتيوليتيك + +370 +00:31:36,730 --> 00:31:38,650 +البروتيوليتيك البروتيوليتيك البروتيوليتيك + +371 +00:31:38,650 --> 00:31:39,050 +البروتيوليتيك البروتيوليتيك البروتيوليتيك + +372 +00:31:39,050 --> 00:31:40,530 +البروتيوليتيك البروتيوليتيك البروتيوليتيك + +373 +00:31:40,530 --> 00:31:45,770 +البروتيوليتيك البروتيوليتيك + +374 +00:31:45,770 --> 00:31:52,370 +البروتيوليتيك وهذه عبارة عن الـ process بنوع من + +375 +00:31:52,370 --> 00:31:57,070 +التفصيل مش راح أطلبكم فيها وهذه عبارة عن صورة ده + +376 +00:31:57,070 --> 00:32:00,870 +هي صار في عندها necrotizing granulomatous lesion + +377 +00:32:00,870 --> 00:32:06,250 +في منطقة الأنف due to TAP deficiency syndrome + +378 +00:32:06,250 --> 00:32:13,350 +وبهيك إن شاء الله بنكون أنهينا المحاضرة نتمنى أن + +379 +00:32:13,350 --> 00:32:16,730 +تكونوا قد استفدتم منها diff --git a/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/9HiEsDjl9XE_postprocess.srt b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/9HiEsDjl9XE_postprocess.srt new file mode 100644 index 0000000000000000000000000000000000000000..7b5415b3034220bb3d1c0dfb9499f4f34bebf439 --- /dev/null +++ b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/9HiEsDjl9XE_postprocess.srt @@ -0,0 +1,1516 @@ +1 +00:00:01,380 --> 00:00:07,080 +باسمه بنتقل اليوم في محاضرة جديدة بعنوان الـ major + +2 +00:00:07,080 --> 00:00:10,640 +histocompatibility complex and antigen + +3 +00:00:10,640 --> 00:00:17,400 +presentation ال + +4 +00:00:17,400 --> 00:00:22,260 +major histocompatibility complex هم مجموعات جينية + +5 +00:00:22,260 --> 00:00:25,620 +مرتبطة جدًا ووظيفتهم + +6 +00:00:25,620 --> 00:00:29,260 +الأساسية هو عبارة عن intracellular recognition + +7 +00:00:31,750 --> 00:00:38,510 +antigen and self-mental discrimination ويلهم مظائف + +8 +00:00:38,510 --> 00:00:43,230 +مهمة جدا في ال transplantation مسئولين عن + +9 +00:00:43,230 --> 00:00:48,630 +transplant rejection شوان كان في حالة الhistoin + +10 +00:00:48,630 --> 00:00:53,150 +compatibility كمان يلهم دور في ال humor and self + +11 +00:00:53,150 --> 00:00:59,140 +-mediated immunity ويلهم دور مهم جدافي الـ Antigen + +12 +00:00:59,140 --> 00:01:04,400 +recognition by T lymphocytes أول + +13 +00:01:04,400 --> 00:01:08,580 +من حكى في هذا الموضوع هو جورج روسنيل في 1930 في + +14 +00:01:08,580 --> 00:01:13,460 +1980 أخد نوبل برايز على هذا الموضوع ال location + +15 +00:01:13,460 --> 00:01:17,840 +جاله هذه الجينات ان ال human موجودة على كرمزوم رقم + +16 +00:01:17,840 --> 00:01:23,200 +6 و بيسموها MHC major histocompatibility complex + +17 +00:01:23,200 --> 00:01:30,580 +geneأو HLA أو human leukocyte antigen and they are + +18 +00:01:30,580 --> 00:01:35,940 +recognized in a region encoded three classes of + +19 +00:01:35,940 --> 00:01:41,040 +molecule تلت أنواع من ال MLC موجودة وهي تحت في ال + +20 +00:01:41,040 --> 00:01:47,270 +human في عنا three regionsالأولانية بيسموها region + +21 +00:01:47,270 --> 00:01:57,470 +number A ثم B ثم C و هدول التلاتة ل class 1 ثم ال + +22 +00:01:57,470 --> 00:02:02,490 +region D هي ل class 2 يبقى في أنها تلت أنواع من + +23 +00:02:02,490 --> 00:02:08,370 +MSC class molecule اللي هو class 1 و class 2 و + +24 +00:02:08,370 --> 00:02:15,400 +class 3موجودين على كرمزوم رقم ستة في موزعين في + +25 +00:02:15,400 --> 00:02:21,260 +أربع مناطق اربع four different regions دي ABC ثم D + +26 +00:02:21,260 --> 00:02:27,720 +يتوسطهم class تلاتة و for unknown reason for + +27 +00:02:27,720 --> 00:02:33,340 +unknown reason هال كرمزوم رقم ستة على الشورط أرض + +28 +00:02:33,340 --> 00:02:40,220 +كرمزوم رقم ستة اسمها HLA regionوهي مقسمة إلى تلت + +29 +00:02:40,220 --> 00:02:45,660 +تلاتة different types of genes class واحد class + +30 +00:02:45,660 --> 00:02:50,160 +اتنين class تلاتة طبعا زي ما انتوا شايفين في عندنا + +31 +00:02:50,160 --> 00:02:55,580 +gene و في صوت جين انما كلهم احنا معانيين باش ال + +32 +00:02:55,580 --> 00:02:56,560 +functional gene + +33 +00:03:00,220 --> 00:03:04,540 +وهذه طبعا صورة بتبين لي بوضوح تركيبة كل واحد منهم + +34 +00:03:04,540 --> 00:03:13,120 +هي ال A class 1 ABC بيتكون من alpha-polypeptide + +35 +00:03:13,120 --> 00:03:21,760 +linked with B2-microglobulin protein كوّن لي اللي + +36 +00:03:21,760 --> 00:03:31,750 +هو ال MHC او ال HLAرقم A هو ده بيتكوّن من تلاتة + +37 +00:03:31,750 --> 00:03:36,050 +domain لـ Alpha مع بيتته Micro Global كل واحد من + +38 +00:03:36,050 --> 00:03:43,850 +هدول اللي هو نفس التركيبة بينما class 2 بيتكوّن من + +39 +00:03:43,850 --> 00:03:53,250 +DR, DQ و DB ماشي و كل واحد منهم بيتكوّن من two + +40 +00:03:53,250 --> 00:04:00,380 +polypeptideA to region طبعاً A و B اللي فيها two + +41 +00:04:00,380 --> 00:04:03,580 +pre-peptide Alpha و Beta و اللي بيكونولي في + +42 +00:04:03,580 --> 00:04:10,080 +النهاية الـDR و الـDQ و الـDB طبعا ال Alpha و Beta + +43 +00:04:10,080 --> 00:04:14,860 +chain كل واحدة منهم زي ما انتوا شايفين تتكون من + +44 +00:04:14,860 --> 00:04:20,860 +two domain Alpha 1 و Alpha 2 و Beta 1 و Beta 2 and + +45 +00:04:20,860 --> 00:04:25,000 +they configure in a shape resemblingأو الـ + +46 +00:04:25,000 --> 00:04:29,820 +Immunoglobulin Structure هذا هو نفس الحكاية لأن + +47 +00:04:29,820 --> 00:04:32,900 +كلهم يندرجوا تحت الـ Immunoglobulin Gen + +48 +00:04:32,900 --> 00:04:38,480 +Superfamily Class I MHC Molecule هو ميدياة إيمينو + +49 +00:04:38,480 --> 00:04:41,600 +ريسبونسيه ضد الاندوجينس وظيفته يتعرف على + +50 +00:04:41,600 --> 00:04:47,320 +الاندوجينس انتجن اللي موجود في الجلد + +51 +00:05:02,430 --> 00:05:06,870 +الخلايا اللي بيصير فيها طبعا هذه الانتجينات + +52 +00:05:06,870 --> 00:05:16,880 +الداخلية اندوجنس اما viral او tumor antigen الالـ + +53 +00:05:16,880 --> 00:05:22,660 +MHC موليكول بيرتبط بـ Antigenic Peptide حجمها 8 + +54 +00:05:22,660 --> 00:05:27,860 +إلى 10 Amino Acids اللي بعد هيك تتقدم للـ + +55 +00:05:27,860 --> 00:05:34,230 +Cytotoxic T Lymphocyte اللي هي CD8ووجدوا ان ال MSC + +56 +00:05:34,230 --> 00:05:38,150 +class 1 موجود على كل خلايا الجسم وبالتالي اي خلية + +57 +00:05:38,150 --> 00:05:43,310 +بيصير فيها infection سواء virally او tumor تستطيع + +58 +00:05:43,310 --> 00:05:47,530 +ان تقدم الانتجين لساعة ال toxic تيرينفسايت تخلصنا + +59 +00:05:47,530 --> 00:05:54,270 +منه ال class 2 بيبقى اي اميون response against + +60 +00:05:54,270 --> 00:05:57,930 +exogenous انتجان الانتجانات القارجية اللي موجودين + +61 +00:05:57,930 --> 00:06:05,720 +برا الخليةو Class II يرتبط بـ Peptide حجمها 13 لـ + +62 +00:06:05,720 --> 00:06:10,580 +18 Amino Acids in size that are presented to T + +63 +00:06:10,580 --> 00:06:15,420 +-Helper cell and recognized by it الـ MHC Class II + +64 +00:06:15,420 --> 00:06:19,860 +موجود على خلايا محددة مش على كل خلايا الجسم موجود + +65 +00:06:19,860 --> 00:06:23,580 +على الـ P-Lymphocytes على الـ Macrophageعالـ + +66 +00:06:23,580 --> 00:06:27,140 +Monocyte, Dendritic Cell وIndothelial Cells واذا + +67 +00:06:27,140 --> 00:06:31,600 +لاحظنا ان هذه الخلايا هي عبارة عن Antigen + +68 +00:06:31,600 --> 00:06:38,060 +Presenting Cell هذين فجوسيتيك ويمكن انه يدخل + +69 +00:06:38,060 --> 00:06:42,900 +بسهولة الـ Extracellular Antigen Class III زي ما + +70 +00:06:42,900 --> 00:06:49,320 +قلنالكوا ليس لديه رول في الانتجين برزنتيشن لكنه + +71 +00:06:49,320 --> 00:06:52,200 +يتكود لسكريت البروتين + +72 +00:06:56,360 --> 00:07:01,160 +من خلال البروسيس الدينية وجوده ما بين class 1 و + +73 +00:07:01,160 --> 00:07:06,800 +class 2 هو غير متأكد بمعناه مش محروف او مش مؤكد + +74 +00:07:06,800 --> 00:07:11,020 +لما + +75 +00:07:11,020 --> 00:07:18,160 +تشوف هبلو تايب جاله كل ستة جينات موجودة على سنك + +76 +00:07:18,160 --> 00:07:24,510 +الكرومزومماشي set of genes بيسموها haplotype يبقى + +77 +00:07:24,510 --> 00:07:28,990 +ال haplotype هي برعنة set of gene ل class واحد و + +78 +00:07:28,990 --> 00:07:32,070 +set of gene ل class اتنين مرتبطين على one + +79 +00:07:32,070 --> 00:07:35,530 +chromosome وجودين على chromosome واحد اللي هو رقم + +80 +00:07:35,530 --> 00:07:41,610 +ستة و كلهم collectively are known as haplotype و + +81 +00:07:41,610 --> 00:07:44,550 +ال individual عنده two haplotype واحد جاي من ال + +82 +00:07:44,550 --> 00:07:49,350 +maternal واحد جاي من ال paternalوهذه الجينات + +83 +00:07:49,350 --> 00:07:56,530 +موصولة معايا يعني يورثوا مع بعض مادية ومادية + +84 +00:07:56,530 --> 00:08:04,810 +برودكت موصولة في نفس الجسيم.الكلاس وان الستركترات + +85 +00:08:04,810 --> 00:08:09,770 +التي اتفقنا بها تكوين من الفا، عبارة عن عبارة عن + +86 +00:08:09,770 --> 00:08:14,770 +عبارة عن عبارة عن عبارة عن عبارة عن عبارة عنوالـ + +87 +00:08:14,770 --> 00:08:17,170 +Alpha هي عبارة عن Polymorphic Transmembraic + +88 +00:08:17,170 --> 00:08:22,510 +Lycoprotein بيتكوّن من three domain بيتكوّن مناشر + +89 +00:08:22,510 --> 00:08:27,250 +three domain Alpha 1, Alpha 2, Alpha 3 مرتبطة بال + +90 +00:08:27,250 --> 00:08:30,970 +Beta 2-microlipid وعبارة عن invariant protein + +91 +00:08:30,970 --> 00:08:38,670 +encoded by a gene on a different chromosomeطبعا ال + +92 +00:08:38,670 --> 00:08:44,110 +association بين Alpha و Beta 2 microglobulin مطلوب + +93 +00:08:44,110 --> 00:08:50,810 +جدا for the expression class I on cell membrane و + +94 +00:08:50,810 --> 00:08:56,730 +ده هو أي Alpha يتكوّن من ثلاثة دومين Alpha 1 Alpha + +95 +00:08:56,730 --> 00:09:02,370 +2 Alpha 3 مرتبطة ب Beta 2 microglobulinالجزء + +96 +00:09:02,370 --> 00:09:08,030 +البراني اللي هو extra cellular ده هو براني three + +97 +00:09:08,030 --> 00:09:14,210 +اللي هو عبارة عن invariant chains بمعنى هي عبارة + +98 +00:09:14,210 --> 00:09:22,250 +عن variable و ال peptide بيرتبط في هذه المنطقة + +99 +00:09:22,250 --> 00:09:29,220 +باسمها peptide cleft او peptide binding growthماشي + +100 +00:09:29,220 --> 00:09:35,100 +Alpha 3 و Beta 2 microglobulin are constant region + +101 +00:09:35,100 --> 00:09:44,680 +و CD8 بيرتبط غالبا بال Alpha 3 بيرتبط بال Alpha 3 + +102 +00:09:44,680 --> 00:09:50,440 +ال molecule أيضا فيه Trans membrane و فيه short + +103 +00:09:50,440 --> 00:09:56,950 +cytoplasmic tailstructure collectively زي ما انتوا + +104 +00:09:56,950 --> 00:10:06,010 +شايفين resembling immunoglobulin in shape and even + +105 +00:10:06,010 --> 00:10:11,850 +structure بينما ال class two structure بتتكون من + +106 +00:10:11,850 --> 00:10:15,770 +two polyp بتاعة واحدة Alpha واحدة Beta وكل واحدة + +107 +00:10:15,770 --> 00:10:19,430 +بتتكون من two domain Alpha one Alpha twoوبيتا وان + +108 +00:10:19,430 --> 00:10:26,230 +وبيتا تو ايضا ال antigen binding موجود بين الفا + +109 +00:10:26,230 --> 00:10:31,110 +واحد وبيتا واحد مرانيو كما تشاهدين الانتجينيك + +110 +00:10:31,110 --> 00:10:37,550 +بيبتعد شويه اكبر وبالتالي بيستطي بعاد شويه عن بعض + +111 +00:10:37,550 --> 00:10:45,470 +بالتالي بيرتبطوا بانتجينيك بيبتعد شويه اكبر ماشي + +112 +00:10:45,470 --> 00:10:50,070 +ايضا له Transmembrane and cytoplasmic tail + +113 +00:10:57,020 --> 00:11:00,100 +بالمناسبة Alpha 1 Beta 1 هي عبارة عن الـ Variable + +114 +00:11:00,100 --> 00:11:03,180 +و Alpha 2 Beta 2 هي عبارة عن الـ Concentration + +115 +00:11:03,180 --> 00:11:09,380 +وهذا الجدول يظهر الفروقات بين Class 1 و Class 2 + +116 +00:11:09,380 --> 00:11:15,740 +يتكوّن من Alpha 1 Alpha 2 إلى Alpha 1 Beta 1 + +117 +00:11:15,740 --> 00:11:21,320 +لمنطقة الأرتباط بالـ Antigenطبعا هذه المنطقة مسكرة + +118 +00:11:21,320 --> 00:11:26,420 +في class 1 لكنها مفتوحة في class 2 ف ال size of + +119 +00:11:26,420 --> 00:11:32,860 +peptide 18 شوية صغير لكنها من 13 ل 18 لأنها مفتوحة + +120 +00:11:32,860 --> 00:11:38,520 +و أكبر ال peptide motif anchor residue at both + +121 +00:11:38,520 --> 00:11:45,040 +ends of peptide and generally hydrophobic carboxyl + +122 +00:11:45,040 --> 00:11:48,750 +terminal اللي بيبقوا طلعةهذه نفس الحكاية Anchor + +123 +00:11:48,750 --> 00:11:52,030 +residue distributed along the length of the + +124 +00:11:52,030 --> 00:11:58,870 +peptide على طول الـpeptide initial and bound هذا + +125 +00:11:58,870 --> 00:12:05,130 +بيرتبط بان الانتصارين + +126 +00:12:05,130 --> 00:12:07,230 +يتعامل مع عمق الشيخ اليسار + +127 +00:12:10,160 --> 00:12:16,280 +وهذا اتسلب at a constant elevation above the floor + +128 +00:12:16,280 --> 00:12:24,880 +of MHC cleft MHC + +129 +00:12:24,880 --> 00:12:29,780 +class 1 per class 2 peptide interaction طبعا ترتبط + +130 +00:12:29,780 --> 00:12:33,400 +بالpeptide and presented to CD4 T-Helper cell and + +131 +00:12:33,400 --> 00:12:38,650 +it can bind to a variety of peptideوبتعمل + +132 +00:12:38,650 --> 00:12:41,930 +Indocytic Processing Pathway نتعرف عليه قدام + +133 +00:12:41,930 --> 00:12:47,710 +Polymorphism of class 1 و2 قالوا ال polymorphism + +134 +00:12:47,710 --> 00:12:51,450 +هو عبارة عن ال presence of multiple alleles at a + +135 +00:12:51,450 --> 00:12:57,030 +given genetic locus within a species ووجدوا انه at + +136 +00:12:57,030 --> 00:13:03,110 +class 1 و class 2 there areفي هذه المناطق علشان هي + +137 +00:13:03,110 --> 00:13:09,470 +Polymorphism Polymorphic جين Diversity of MHC + +138 +00:13:09,470 --> 00:13:14,350 +within a species results from this polymorphism و + +139 +00:13:14,350 --> 00:13:17,650 +ال MHC expressed by individual does not change + +140 +00:13:17,650 --> 00:13:22,690 +over the time لكن فيه different significantly + +141 +00:13:22,690 --> 00:13:29,930 +between individual within the same speciesبيقول ان + +142 +00:13:29,930 --> 00:13:33,770 +في عشر القوات ناحية theoretical diversity في الميس + +143 +00:13:33,770 --> 00:13:38,530 +من class 1 و class 2 يعني هي من class 1 بيقولوا + +144 +00:13:38,530 --> 00:13:47,010 +class 2 يعني أقل شوية عشر القوات عشرة polymorphism + +145 +00:13:47,010 --> 00:13:53,890 +of class 1 و 8 أيضا this will serve as antigenالـ + +146 +00:13:53,890 --> 00:13:59,470 +MHC موليكيول ستعمل كانتجين لكي تسمح بإنسانك بمعرفة + +147 +00:13:59,470 --> 00:14:05,070 +ما هو نفسك وما هو غير نفسك مجموعات مختلفة الاليليل + +148 +00:14:05,070 --> 00:14:12,050 +تعمل ان الانتجين هو MHC موليكيول وفي كل جنس هناك + +149 +00:14:12,050 --> 00:14:16,490 +الكثير من الاليليل المهم في هذا الموضوع ان هناك + +150 +00:14:16,490 --> 00:14:21,430 +الكثير من الاليليل وكثير من المجموعات وبالتالي لا + +151 +00:14:21,430 --> 00:14:22,190 +يمكن ان يكون هناك + +152 +00:14:28,320 --> 00:14:33,060 +لكن عملية الترانسبلانتيشن ليست مستحيلة اليوم يوجد + +153 +00:14:33,060 --> 00:14:39,360 +ألف عضلات من عضلات ترانسبلانتيشن كل عام ونتطلع + +154 +00:14:39,360 --> 00:14:45,920 +لهذا الموضوع في عرض ترانسبلانتيشن Class III هم + +155 +00:14:45,920 --> 00:14:48,160 +مجموعات مختلفة ومستعمرة ومفتوحة ومستعمرة ومستعمرة + +156 +00:14:48,160 --> 00:14:48,980 +ومستعمرة ومستعمرة ومستعمرة ومستعمرة ومستعمرة + +157 +00:14:48,980 --> 00:14:50,360 +ومستعمرة ومستعمرة ومستعمرة ومستعمرة ومستعمرة + +158 +00:14:50,360 --> 00:14:51,000 +ومستعمرة ومستعمرة ومستعمرة ومستعمرة ومستعمرة + +159 +00:14:51,000 --> 00:14:51,220 +ومستعمرة ومستعمرة ومستعمرة ومستعمرة ومستعمرة + +160 +00:14:51,220 --> 00:14:56,570 +ومستعمرة ومستعمرة ومستعمرة وهم يحتوي على مجموعات + +161 +00:14:56,570 --> 00:14:59,810 +متشابهة مختلفة مثل الـ Human Necrosis Factor أو + +162 +00:14:59,810 --> 00:15:01,230 +الـ Heat Shock Protein أو الـ Heat Shock Protein + +163 +00:15:01,230 --> 00:15:02,130 +أو الـ Heat Shock Protein أو الـ Heat Shock + +164 +00:15:02,130 --> 00:15:06,310 +Protein أو الـ Heat + +165 +00:15:06,310 --> 00:15:06,430 +Shock Protein أو الـ Heat Shock Protein أو الـ + +166 +00:15:06,430 --> 00:15:08,810 +Heat Shock Protein أو الـ Heat Shock Protein أو + +167 +00:15:08,810 --> 00:15:12,010 +الـ Heat Shock Protein أو الـ Heat Shock Protein + +168 +00:15:12,010 --> 00:15:12,070 +أو الـ Heat Shock Protein أو الـ Heat Shock + +169 +00:15:12,070 --> 00:15:12,090 +الـ Heat Shock Protein أو الـ Heat Shock Protein + +170 +00:15:12,090 --> 00:15:12,870 +Protein أو الـ Heat Shock Protein أو الـ Heat + +171 +00:15:12,870 --> 00:15:16,370 +Shock Protein أو الـ Heat Shock Protein أو الـ + +172 +00:15:16,370 --> 00:15:21,610 +Heat Shock Protein أو الـ Heat Shock + +173 +00:15:21,610 --> 00:15:23,910 +Protein أو الـ Heat Shock Protein أو الـ Heat + +174 +00:15:23,910 --> 00:15:27,710 +Shock Proteهيلي كونزيرف دي بروتين بينوجد فيه فيه + +175 +00:15:27,710 --> 00:15:36,650 +اوقات غير طبيعية وفي محفزات كثيرة لإنتاج ذو سيد شك + +176 +00:15:36,650 --> 00:15:41,830 +بروتين ماشي منها على سبيل المثال الـ nutrient + +177 +00:15:41,830 --> 00:15:45,930 +deprivation مجععات اكسجين راديكال and viral + +178 +00:15:45,930 --> 00:15:52,410 +infection كل عبارة عن محفزات لخيكشك بروتين + +179 +00:15:52,410 --> 00:15:56,010 +productionوهي مرتبطة بشكل عام بشكل عام بشكل عام + +180 +00:15:56,010 --> 00:15:58,170 +بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل + +181 +00:15:58,170 --> 00:16:01,070 +عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام + +182 +00:16:01,070 --> 00:16:02,850 +بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل + +183 +00:16:02,850 --> 00:16:03,930 +عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام + +184 +00:16:03,930 --> 00:16:04,770 +بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل + +185 +00:16:04,770 --> 00:16:08,050 +عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام + +186 +00:16:08,050 --> 00:16:12,920 +عام بشكل عام بprocessing and presentation هذه + +187 +00:16:12,920 --> 00:16:16,040 +مصطلحين عندنا ال processing هي عبارة عن عملية + +188 +00:16:16,040 --> 00:16:21,960 +تجهيز وتشجيف وتقطيع ال antigen ماشي بسموها + +189 +00:16:21,960 --> 00:16:25,800 +processing و ال presentation هي عبارة عن عملية + +190 +00:16:25,800 --> 00:16:29,180 +تقديم ال antigen بيرتبط من MSH مليكيول على سطح + +191 +00:16:29,180 --> 00:16:34,680 +الخلية و بيتقدم لمين ل T cell يبقى ال processing + +192 +00:16:34,680 --> 00:16:39,730 +هو عبارة عن عملية ايهاش ال degradationof antigen + +193 +00:16:39,730 --> 00:16:47,330 +into peptide و ال presentation هو عبارة عن تقديم + +194 +00:16:47,330 --> 00:16:55,910 +هذا ال antigen ل T cell ال class I برتبط موليكيوه + +195 +00:16:55,910 --> 00:16:59,530 +طبعا عملشي موليكيوه بايد بيبتايد derived from + +196 +00:16:59,530 --> 00:17:00,250 +endogenous + +197 +00:17:03,260 --> 00:17:06,260 +هذا الانتجن الاندوجيني يمكن ان يتم تصميمه في + +198 +00:17:06,260 --> 00:17:10,440 +الانسان والسيطابلزام بينما الكلاس 2 يرتبط بانتجن + +199 +00:17:10,440 --> 00:17:15,180 +اكسوجيني يعني جاية من برا انتجنيا بفاجوسيتوسيا او + +200 +00:17:15,180 --> 00:17:19,880 +اندوستيتوسيا بسرعة التصميم الاندوستيكي التي + +201 +00:17:19,880 --> 00:17:25,430 +سنشاهدها الآنبما أننا ندخل في عملية الـ Processing + +202 +00:17:25,430 --> 00:17:28,950 +و الـ Presentation نريد أن نأكد على عملية الـ MHC + +203 +00:17:28,950 --> 00:17:32,450 +أو Self-MHC Restriction بمعنى أن الـ T-Lymphocyte + +204 +00:17:32,450 --> 00:17:38,190 +لا تتعامل إلا مع MHC مليكيول شافته قبل هيك within + +205 +00:17:38,190 --> 00:17:42,210 +the same species وين في الـ Thymus مش تقدملها و هي + +206 +00:17:42,210 --> 00:17:48,150 +بتتعلم و تتدرب وبالتالي ما لا تتعامل مع MHC from + +207 +00:17:48,150 --> 00:17:51,390 +other individual + +208 +00:17:53,210 --> 00:17:59,430 +طبعا في اتنين علماء ده هم زي انجرنيجل ودوارتي + +209 +00:17:59,430 --> 00:18:07,290 +عملوا تجربة ليسبب تقول ذلك فراحوا ايش عملوا ده هي + +210 +00:18:07,290 --> 00:18:13,490 +طبعا دي اللي هو التجربة خلينا نشوفها ده هو جابوا + +211 +00:18:13,490 --> 00:18:22,010 +فار وحقنوه ب ال ال CM ال virus اللي هو ال + +212 +00:18:24,930 --> 00:18:33,730 +Lymphocyte Chorium meningitis virus وبعد + +213 +00:18:33,730 --> 00:18:39,770 +أسبوعين أخدوا خلايا من الـSpleen هذه الخلايا تحتوي + +214 +00:18:39,770 --> 00:18:48,170 +على T-cytotoxic وهي بتكون Alliard يعني جاهزة للتأ + +215 +00:18:48,170 --> 00:18:55,400 +للقتل ثم عملوا incubation لهذه الخلايامع target + +216 +00:18:55,400 --> 00:19:06,600 +cell من اللي هو نفس الفار لكن هو مش infected و مع + +217 +00:19:06,600 --> 00:19:11,720 +نفس الفار لكن الخلايا تبعته infected و مع فار من + +218 +00:19:11,720 --> 00:19:18,520 +نوع تاني و طبعا ال antigen is already labeled by + +219 +00:19:18,520 --> 00:19:24,400 +groupوطلعوا على النتيجة وجهوا انه في ال not + +220 +00:19:24,400 --> 00:19:29,940 +infected cell ماصللهاش اشي و ال infected cell من + +221 +00:19:29,940 --> 00:19:35,840 +نفس الفار اي 2K H2K وهي الفار H2K من نفس الفار + +222 +00:19:35,840 --> 00:19:41,680 +صللها license بينما اللي اجت من الفار تاني هي 2B + +223 +00:19:41,680 --> 00:19:45,200 +there is no license بمعنى لم تتعرف عليها ولم + +224 +00:19:45,200 --> 00:19:55,520 +تعجبها ماشييعني لو حطناها في part تاني لن + +225 +00:19:55,520 --> 00:19:59,520 +تترف على اللي هو الأمشي موليكيولو تبعها + +226 +00:20:02,540 --> 00:20:06,740 +الـ Self-restriction طبعا لـ CD4 و CD8 احنا قلنا + +227 +00:20:06,740 --> 00:20:16,640 +لجيتها لـ CT cytotoxic خدنا نشوف تجربة عندهم لCD4 + +228 +00:20:16,640 --> 00:20:21,900 +طبعا جابوا two strain لكن الـ strain هدول هجين + +229 +00:20:21,900 --> 00:20:31,520 +ماشي من الخنازير strain 2 و 13 واحد strain 2 و 13 + +230 +00:20:32,110 --> 00:20:36,570 +عرضوا لواحد اعطوا واحد antigen واستنوا سبع ايام + +231 +00:20:36,570 --> 00:20:41,210 +وراحوا على الانفنوس لو بوها كبرت فاخدوا منها ال + +232 +00:20:41,210 --> 00:20:45,270 +macro phage فدل حالة ال macro phage هي عبارة عن ال + +233 +00:20:45,270 --> 00:20:49,130 +yard cell هتاخد ال antigen هتاخد ال antigen + +234 +00:20:49,130 --> 00:20:53,330 +المجموعة + +235 +00:20:53,330 --> 00:20:58,930 +التانية اللي هي برضه نفس انواع ال strains أخدتوا + +236 +00:20:58,930 --> 00:21:00,690 +من ال peritoneal exudate cell + +237 +00:21:03,940 --> 00:21:13,880 +وعملوها طبعاً اديرانس في petri dish وبعد ذلك اخذوا + +238 +00:21:13,880 --> 00:21:18,180 +ال peritoneal macrophage وعرضوها ل antigen + +239 +00:21:18,180 --> 00:21:24,620 +وبالتالي صارت antigen presenting cell يبقى هنا هي + +240 +00:21:24,620 --> 00:21:29,380 +برهان خلية اخدوا T lymphocyte من هنا sorry antigen + +241 +00:21:29,380 --> 00:21:30,280 +prime T cell + +242 +00:21:33,180 --> 00:21:39,860 +أخذوا الـ T lymphocytes من الـ lymph nodes اللي هي + +243 +00:21:39,860 --> 00:21:44,440 +CD4 وهنا حضروا اللي هو الـ antigen presenting cell + +244 +00:21:44,440 --> 00:21:49,380 +والثانيين حضروهم يعني they add to each other all + +245 +00:21:49,380 --> 00:21:55,960 +of them and they culture media طبعا النتائج قالوا + +246 +00:21:55,960 --> 00:21:59,580 +لما حطينا stream 2 + +247 +00:22:02,290 --> 00:22:08,950 +T Cell من Strain 2 مع Antigen Presenting Cell من + +248 +00:22:08,950 --> 00:22:14,070 +Strain 2 صار فيه تفاعل أيه وزده لكن لما صار لما + +249 +00:22:14,070 --> 00:22:19,850 +حطناها مع Strain 13 ماصار و لما حطناها مع الهجين + +250 +00:22:19,850 --> 00:22:28,950 +اللي هو 8 و 13 صار نفس الحكاية بالنسبة لـ 13مع + +251 +00:22:28,950 --> 00:22:34,230 +strain 2 ماصار اجتفاع مع strain 13 صار مع الهجين + +252 +00:22:34,230 --> 00:22:40,870 +ايضا صار strain الهجين ده هو اللي لما حطينا الخلية + +253 +00:22:40,870 --> 00:22:45,730 +الهجين تيليمفوسايت من ال strain الهجين حطيناها مع + +254 +00:22:45,730 --> 00:22:55,740 +strain 2 و strain 13 و strainو لا جين كلها ماتت + +255 +00:22:55,740 --> 00:23:01,460 +اللي هو التفاعل دليل على ان ال antigen present او + +256 +00:23:01,460 --> 00:23:05,700 +ال T-lymphocyte لها تتعرف على انتجن مرتبط ب MSC + +257 +00:23:05,700 --> 00:23:10,180 +ملكيول from the same species + +258 +00:23:10,180 --> 00:23:15,630 +from the same individual of the same speciesطيب + +259 +00:23:15,630 --> 00:23:18,850 +انتجين presenting cell يعني انتجين presenting cell + +260 +00:23:18,850 --> 00:23:22,870 +زي ما اتفقناها اما ال c class واحد موجود على كل + +261 +00:23:22,870 --> 00:23:25,990 +خلايا الجسم ويوم تصير infected بيسموها target cell + +262 +00:23:25,990 --> 00:23:31,310 +بينما اما ال c class 2 موجود على ايش على certain + +263 +00:23:31,310 --> 00:23:31,830 +cell + +264 +00:23:34,680 --> 00:23:40,000 +وقسمهم إلى الـ Antigen Presenting Cell وقسم مشكلة + +265 +00:23:40,000 --> 00:23:44,120 +خلايا الجسم وقسمهم إلى نوعين Professional Antigen + +266 +00:23:44,120 --> 00:23:46,060 +Presenting Cell وهي عبارة عن الـ Dendritic Cell + +267 +00:23:46,060 --> 00:23:49,320 +وMacrophage B Cell وNon Professional باقي الخلايا + +268 +00:23:49,320 --> 00:23:51,980 +اللي احنا حكينا عنها زي الـ Fibroblast, Glial و + +269 +00:23:51,980 --> 00:23:58,300 +Pancreatic Cell اللي موجودة في أماكن مختلفة ال + +270 +00:23:58,300 --> 00:24:01,080 +processing زي ما قلنا في عندنا ال extra cellular + +271 +00:24:01,080 --> 00:24:02,140 +او ال extragenous + +272 +00:24:14,230 --> 00:24:17,270 +انتجن انتجن انتجن انتجن انتجن انتجن انتجن انتجن + +273 +00:24:17,270 --> 00:24:17,630 +انتجن انتجن انتجن انتجن انتجن انتجن انتجن انتجن + +274 +00:24:17,630 --> 00:24:18,950 +انتجن انتجن انتجن انتجن انتجن انتجن انتجن انتجن + +275 +00:24:18,950 --> 00:24:21,810 +انتجن انتجن انتجن انتجن انتجن انتجن انتجن انتجن + +276 +00:24:21,810 --> 00:24:22,570 +انتجن انتجن انتجن انتجن انتجن انتجن انتجن انتجن + +277 +00:24:22,570 --> 00:24:23,210 +انتجن انتجن انتجن انتجن انتجن انتجن انتجن انتجن + +278 +00:24:34,250 --> 00:24:37,150 +الأنتيجن برزانتيج سيل بتاخد الانتيجن اما by + +279 +00:24:37,150 --> 00:24:44,030 +phagocytosis او اندو سايتوسيز متى ما اخدت الانتيجن + +280 +00:24:44,030 --> 00:24:47,150 +طبعا ال micro facial بتاع مابتشتغل بجهتين لكن + +281 +00:24:47,150 --> 00:24:53,110 +بيليب فصعد بس بتاخد الانتيجن by اندو سايتوسيز بيخش + +282 +00:24:53,110 --> 00:24:58,380 +الانتيجن جوا بيبدأ يسرله degradationationطبعاً + +283 +00:24:58,380 --> 00:25:02,400 +عملية تأخذ عامة ثلاث ساعات من ساعة على ثلاث ساعات + +284 +00:25:02,400 --> 00:25:07,360 +عشان يكتمل و يطلع ال MSC موليكيول مرتبط بال class + +285 +00:25:07,360 --> 00:25:12,600 +2 MSC موليكيول مرتبط بالانتيجن ال internalized + +286 +00:25:12,600 --> 00:25:18,540 +antigen ده هي الحكاية وببساطة هي مشروحة فهي ال + +287 +00:25:18,540 --> 00:25:25,640 +antigen طبعا مرتبطة ده هو بال receptor دخل هو + +288 +00:25:25,640 --> 00:25:29,030 +عبارة عن antibodyفي physical بيسموها clathrin + +289 +00:25:29,030 --> 00:25:36,150 +-coated physical في ال .. في هذه ال physical ماشي + +290 +00:25:36,150 --> 00:25:44,270 +بيصير في sudden drop لل .. اللي هو لل pH فبصير في + +291 +00:25:44,270 --> 00:25:50,270 +release .. release للأنتجةوبفلة اللي هو ال + +292 +00:25:50,270 --> 00:25:53,870 +receptor اللي برجع تاني ال receptor مرة تانية على + +293 +00:25:53,870 --> 00:25:59,010 +ال surface بينما ال antigen صار في داخل ال vesicle + +294 +00:25:59,010 --> 00:26:04,110 +ال vesicle ها دي بيتمر في عدة أداء بعتبروها اللي + +295 +00:26:04,110 --> 00:26:08,910 +هو early endosome ثم بتنتقل إلى مرحلة تانية اللي + +296 +00:26:08,910 --> 00:26:10,670 +هي عبارة عن late endosome + +297 +00:26:13,090 --> 00:26:18,190 +ماشي في ال Indoplasmic reticulum في مكان آخر من + +298 +00:26:18,190 --> 00:26:23,190 +الخلية بيتم تصنيع اللي هو ال MSC موليكيول بيتصنع + +299 +00:26:23,190 --> 00:26:27,190 +بيروح الجولجيا أبراطس بيطلع من الجولجيا أبراطس + +300 +00:26:27,190 --> 00:26:30,870 +انها physical و أثناء عركة الخلية two physical + +301 +00:26:30,870 --> 00:26:35,710 +fused together و بيكونوا one physical فبصير ال + +302 +00:26:35,710 --> 00:26:39,930 +physical اللي متكونت هي عبارة عن physical فيها MSC + +303 +00:26:39,930 --> 00:26:48,860 +موليكيول و أنتجلطبعا في هذه الحالة الليزوزوم + +304 +00:26:48,860 --> 00:26:51,800 +يدخل ويعمل degradation ويشجف على ال sugar في صغيرة + +305 +00:26:51,800 --> 00:26:59,600 +ويشجف على ال sugar + +306 +00:26:59,600 --> 00:27:02,200 +في صغيرة ويشجف على ال sugar في صغيرة ويشجف على ال + +307 +00:27:02,200 --> 00:27:03,220 +sugar في صغيرة ويشجف على ال sugar في صغيرة ويشجف + +308 +00:27:03,220 --> 00:27:04,200 +ويشجف على ال sugar في صغيرة ويشجف على ال sugar في + +309 +00:27:04,200 --> 00:27:04,280 +صغيرة ويشجف على ال sugar في صغيرة ويشجف على ال + +310 +00:27:04,280 --> 00:27:04,920 +sugar في صغيرة ويشجف على ال sugar في صغيرة ويشجف + +311 +00:27:04,920 --> 00:27:06,340 +على ال sugar في صغيرة ويشجف على ال sugar في صغيرة + +312 +00:27:06,340 --> 00:27:07,120 +ويشجف على ال sugar في صغيرة ويشجف على ال sugar في + +313 +00:27:07,120 --> 00:27:11,400 +صغيرة ويشجف على ال sugar + +314 +00:27:15,340 --> 00:27:21,100 +هذه العملية مرة تانية واضحة بكتيريا دخلت خدناها + +315 +00:27:21,100 --> 00:27:28,120 +باي اللي هو ana endocytosis اتكونت physical دخلت + +316 +00:27:28,120 --> 00:27:32,460 +فيها ال isosome كسرتها في مكان اخر من الخلية بتصنع + +317 +00:27:32,460 --> 00:27:37,240 +ال endoclamestic molecule بيروح بعد هي كترين + +318 +00:27:37,240 --> 00:27:41,900 +بيرتبط و اطلع برا هو في رحله على ال cell membrane + +319 +00:27:41,900 --> 00:27:44,020 +ان ال endoclamestic molecule بيطلع على ال cell + +320 +00:27:44,020 --> 00:27:49,020 +membraneماشي فبطلع هو في رهبته بطلع في physical + +321 +00:27:49,020 --> 00:27:52,420 +بضرب في ال physical التاني و بيكونوا physical + +322 +00:27:52,420 --> 00:27:56,620 +واحدة ده هي بيسموها phagolisosome و طبعا بيصير + +323 +00:27:56,620 --> 00:28:02,700 +عملية degradation ل اللي هو ال peptides antigenic + +324 +00:28:02,700 --> 00:28:08,480 +peptide و بترتبط محل ال peptide البديلة اللي كانت + +325 +00:28:08,480 --> 00:28:11,640 +طالعة بالامر السيمونكيول و ما بيطلع مرتبط بال + +326 +00:28:11,640 --> 00:28:13,120 +antigen ده هو السلمة + +327 +00:28:17,000 --> 00:28:21,780 +هذا الـ Exogenous و طوى شرحناه الاندوجنس يعني + +328 +00:28:21,780 --> 00:28:26,280 +الانتيجن في داخل الخلية في داخل الخلية ده هو + +329 +00:28:26,280 --> 00:28:31,980 +الانتيجن اندوجنس انتيجن بسله degradation by + +330 +00:28:31,980 --> 00:28:36,120 +proteasome هو فيه في الخلايا already proteasome + +331 +00:28:36,120 --> 00:28:43,920 +بمقاسات مختلفة المهم الانتيجن بسله degradationوبعد + +332 +00:28:43,920 --> 00:28:50,000 +ذلك الـ Endogenous Antigen يدخل على الـ + +333 +00:28:50,000 --> 00:28:56,920 +Endoplasmic reticulum من خلال تاب بروتين تاب + +334 +00:28:56,920 --> 00:29:01,880 +اختصار ل Transporter Associated Protein + +335 +00:29:04,190 --> 00:29:06,470 +فبيخششوا على الـ endoplasmic reticulum و احنا + +336 +00:29:06,470 --> 00:29:09,490 +عارفين ان في الـ endoplasmic reticulum بيتصنع ال + +337 +00:29:09,490 --> 00:29:13,650 +MSC class I مليكيول فهو بيتصنع already على طول + +338 +00:29:13,650 --> 00:29:17,550 +بيصير فيه عملية binding للـ antigen بيعيش بال MSC + +339 +00:29:17,550 --> 00:29:20,890 +مليكيول فبوضع على ال Eclipse بعدها بيطلع برا + +340 +00:29:20,890 --> 00:29:26,530 +وينتقل على ال cell membrane مرتبط بالMSC مليكيول + +341 +00:29:26,530 --> 00:29:29,750 +ال + +342 +00:29:29,750 --> 00:29:33,730 +Indigenousبنبدأ بشريح الكلام اللي تتواحى هنا بشريح + +343 +00:29:33,730 --> 00:29:36,630 +الكلام اللي تتواحى هنا بشريح الكلام اللي تتواحى + +344 +00:29:36,630 --> 00:29:40,110 +هنا بشريح الكلام اللي تتواحى هنا بشريح الكلام اللي + +345 +00:29:40,110 --> 00:29:41,890 +تتواحى هنا بشريح الكلام اللي تتواحى هنا بشريح + +346 +00:29:41,890 --> 00:29:42,670 +الكلام اللي تتواحى هنا بشريح الكلام اللي تتواحى + +347 +00:29:42,670 --> 00:29:44,330 +هنا بشريح الكلام اللي تتواحى هنا بشريح الكلام اللي + +348 +00:29:44,330 --> 00:29:46,130 +تتواحى هنا بشريح الكلام اللي تتواحى هنا بشريح + +349 +00:29:46,130 --> 00:29:53,910 +الكلام اللي تتواحى هنا بشريح الكلام اللي تتواحى + +350 +00:29:53,910 --> 00:29:58,550 +هنا بشريح الكلام اللي تتواحى هنا بشريح الكلام اللي + +351 +00:29:58,550 --> 00:30:03,830 +تCytosolic نفس الحكاية بس كل ما هناك ان الاندوجنس + +352 +00:30:03,830 --> 00:30:08,450 +انتجن بيصير له labeling بيصير له ubiquitination + +353 +00:30:08,450 --> 00:30:15,310 +بيصير ubiquitin مرتبط بالبروتين ال conjugate ده هو + +354 +00:30:15,770 --> 00:30:20,850 +بتعرف عليه البراتيوزون هو بيشكفه إلى قطع صغيرة + +355 +00:30:20,850 --> 00:30:26,590 +بيسموها low molecular mass polypeptide هدا هو + +356 +00:30:26,590 --> 00:30:31,490 +cytosolic هي ال indigenous antigen بيهي برا عن + +357 +00:30:31,490 --> 00:30:35,250 +active process بيعيب ال quetination هدا هو بتحول + +358 +00:30:35,250 --> 00:30:39,210 +إلى labelledبيتعرف عليه البروتيوزوم بشكفه + +359 +00:30:39,210 --> 00:30:43,750 +الابيبتايد ثم بعد ذلك بيخش داخل الاندوبلازمي + +360 +00:30:43,750 --> 00:30:48,690 +كريتكولام من خلال تاب البروتين اللي برتبط بلامة C + +361 +00:30:48,690 --> 00:30:53,230 +class I موليكيا الاندو سيتيك هو اكسوجين اس انتيجين + +362 +00:30:53,230 --> 00:30:57,410 +بسله اندو سايتوسيز او فايجو سايتوسيز وهو طبعا بيخش + +363 +00:30:57,410 --> 00:31:01,830 +على الاندو سيتيك compartment وهو بتحول الابيبتايد + +364 +00:31:02,420 --> 00:31:07,320 +هذه الـ peptide طبعا تطلع مرتبطة بال MSC class II + +365 +00:31:07,320 --> 00:31:13,420 +molecule طبعا ال باج الشجف هي عبارة عن protein + +366 +00:31:13,420 --> 00:31:17,520 +تتحلل ال amino acids اللي بيروح على اللي هو ال + +367 +00:31:17,520 --> 00:31:25,550 +amino acid الخوريهذا هو البروتيوزيوم البروتيوتليتك + +368 +00:31:25,550 --> 00:31:36,590 +الانزايم البروتيوتليتك + +369 +00:31:36,590 --> 00:31:36,730 +البروتيوتليتك البروتيوتليتك البروتيوتليتك + +370 +00:31:36,730 --> 00:31:38,650 +البروتيوتليتك البروتيوتليتك البروتيوتليتك + +371 +00:31:38,650 --> 00:31:39,050 +البروتيوتليتك البروتيوتليتك البروتيوتليتك + +372 +00:31:39,050 --> 00:31:40,530 +البروتيوتليتك البروتيوتليتك البروتيوتليتك + +373 +00:31:40,530 --> 00:31:45,770 +البروتيوتليتك البروتيوتليتك + +374 +00:31:45,770 --> 00:31:52,370 +البروتيوتليتكو هذه عبارة عن ال process بنوع من + +375 +00:31:52,370 --> 00:31:57,070 +التفصيل مش راح أطلبكوا فيها وهذه عبارة عن صورة ده + +376 +00:31:57,070 --> 00:32:00,870 +هي صار في عندها necrotizing granulomatous lesion + +377 +00:32:00,870 --> 00:32:06,250 +في منطقة الأنف due to TAB deficiency syndrome + +378 +00:32:06,250 --> 00:32:13,350 +وبهيك ان شاء الله بنكون أنهينا المحاضرة نتمنى أن + +379 +00:32:13,350 --> 00:32:16,730 +تكونوا قد استفدتم منها + diff --git a/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/9HiEsDjl9XE_raw.json b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/9HiEsDjl9XE_raw.json new file mode 100644 index 0000000000000000000000000000000000000000..73bd8a90134a8a8ff715a5a0dfb57bf848b18f66 --- /dev/null +++ b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/9HiEsDjl9XE_raw.json @@ -0,0 +1 @@ +{"segments": [{"id": 1, "seek": 2926, "start": 1.38, "end": 29.26, "text": "باسمه بنتقل اليوم في محاضرة 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response", "probability": 0.2498779296875}, {"start": 353.83, "end": 354.27, "word": " against", "probability": 0.5322265625}, {"start": 354.27, "end": 355.09, "word": " exogenous", "probability": 0.929443359375}, {"start": 355.09, "end": 355.59, "word": " انتجان", "probability": 0.725189208984375}, {"start": 355.59, "end": 356.13, "word": " الانتجانات", "probability": 0.8699544270833334}, {"start": 356.13, "end": 356.79, "word": " القارجية", "probability": 0.77587890625}, {"start": 356.79, "end": 357.49, "word": " اللي", "probability": 0.72119140625}, {"start": 357.49, "end": 357.93, "word": " موجودين", "probability": 0.96435546875}, {"start": 357.93, "end": 358.15, "word": " برا", "probability": 0.61279296875}, {"start": 358.15, "end": 358.65, "word": " الخلية", "probability": 0.8640950520833334}], "temperature": 1.0}, {"id": 15, "seek": 38296, "start": 359.52, "end": 382.96, "text": "و Class II يرتبط بـ Peptide حجمها 13 لـ 18 Amino Acids in size that are presented to T-Helper cell and recognized by it الـ MHC Class II موجود على خلايا محددة مش على كل خلايا الجسم موجود على الـ P-Lymphocytes على الـ Macrophage", "tokens": [2407, 9471, 6351, 7251, 43500, 3555, 9566, 4724, 39184, 430, 5250, 482, 11331, 7435, 2304, 11296, 3705, 5296, 39184, 2443, 2012, 2982, 5097, 3742, 294, 2744, 300, 366, 8212, 281, 314, 12, 39, 338, 610, 2815, 293, 9823, 538, 309, 2423, 39184, 34796, 34, 9471, 6351, 3714, 29245, 23328, 15844, 16490, 15040, 25528, 3714, 24401, 41891, 37893, 15844, 28242, 16490, 15040, 25528, 25724, 38251, 3714, 29245, 23328, 15844, 2423, 39184, 430, 12, 43, 25161, 905, 43673, 15844, 2423, 39184, 5707, 11741, 609], "avg_logprob": -0.35749247490641584, "compression_ratio": 1.368663594470046, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 359.52, "end": 359.94, "word": "و", "probability": 0.57421875}, {"start": 359.94, "end": 360.8, "word": " Class", "probability": 0.193603515625}, {"start": 360.8, "end": 361.18, "word": " II", "probability": 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Class", "probability": 0.857421875}, {"start": 375.0, "end": 375.42, "word": " II", "probability": 0.8212890625}, {"start": 375.42, "end": 375.98, "word": " موجود", "probability": 0.9796549479166666}, {"start": 375.98, "end": 376.3, "word": " على", "probability": 0.82958984375}, {"start": 376.3, "end": 376.88, "word": " خلايا", "probability": 0.9593098958333334}, {"start": 376.88, "end": 377.62, "word": " محددة", "probability": 0.9918619791666666}, {"start": 377.62, "end": 377.84, "word": " مش", "probability": 0.54296875}, {"start": 377.84, "end": 378.04, "word": " على", "probability": 0.7939453125}, {"start": 378.04, "end": 378.22, "word": " كل", "probability": 0.9892578125}, {"start": 378.22, "end": 378.56, "word": " خلايا", "probability": 0.97412109375}, {"start": 378.56, "end": 379.06, "word": " الجسم", "probability": 0.9931640625}, {"start": 379.06, "end": 379.86, "word": " موجود", "probability": 0.9529622395833334}, {"start": 379.86, "end": 380.12, "word": " على", "probability": 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"probability": 0.84228515625}, {"start": 774.83, "end": 776.41, "word": " ووجدوا", "probability": 0.894287109375}, {"start": 776.41, "end": 776.77, "word": " انه", "probability": 0.673095703125}, {"start": 776.77, "end": 777.03, "word": " at", "probability": 0.6923828125}, {"start": 777.03, "end": 777.39, "word": " class", "probability": 0.96044921875}, {"start": 777.39, "end": 777.67, "word": " 1", "probability": 0.705078125}, {"start": 777.67, "end": 777.87, "word": " و", "probability": 0.990234375}, {"start": 777.87, "end": 778.13, "word": " class", "probability": 0.352783203125}, {"start": 778.13, "end": 778.45, "word": " 2", "probability": 0.95654296875}, {"start": 778.45, "end": 778.93, "word": " there", "probability": 0.481689453125}, {"start": 778.93, "end": 779.25, "word": " are", "probability": 0.9580078125}], "temperature": 1.0}, {"id": 32, "seek": 80763, "start": 781.43, "end": 807.63, "text": "في هذه المناطق علشان هي Polymorphism Polymorphic جين Diversity of MHC within a species results from this polymorphism و ال MHC expressed by individual does not change over the time لكن فيه different significantly between individual within the same species", "tokens": [41185, 29538, 9673, 1863, 41193, 4587, 11203, 8592, 7649, 39896, 18553, 76, 18191, 1434, 18553, 76, 18191, 299, 10874, 9957, 44187, 295, 34796, 34, 1951, 257, 6172, 3542, 490, 341, 6754, 76, 18191, 1434, 4032, 2423, 34796, 34, 12675, 538, 2609, 775, 406, 1319, 670, 264, 565, 44381, 8978, 3224, 819, 10591, 1296, 2609, 1951, 264, 912, 6172], "avg_logprob": -0.35195975283444936, "compression_ratio": 1.3883495145631068, "no_speech_prob": 4.410743713378906e-06, "words": [{"start": 781.43, "end": 781.77, "word": "في", "probability": 0.5263671875}, {"start": 781.77, "end": 782.07, "word": " هذه", "probability": 0.958984375}, {"start": 782.07, "end": 782.65, "word": " المناطق", "probability": 0.990966796875}, {"start": 782.65, "end": 782.93, "word": " علشان", "probability": 0.7821451822916666}, {"start": 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{"start": 791.55, "end": 791.87, "word": " this", "probability": 0.779296875}, {"start": 791.87, "end": 792.91, "word": " polymorphism", "probability": 0.94482421875}, {"start": 792.91, "end": 794.35, "word": " و", "probability": 0.2218017578125}, {"start": 794.35, "end": 794.43, "word": " ال", "probability": 0.2998046875}, {"start": 794.43, "end": 794.91, "word": " MHC", "probability": 0.876708984375}, {"start": 794.91, "end": 795.33, "word": " expressed", "probability": 0.62060546875}, {"start": 795.33, "end": 795.69, "word": " by", "probability": 0.9228515625}, {"start": 795.69, "end": 796.47, "word": " individual", "probability": 0.73876953125}, {"start": 796.47, "end": 796.85, "word": " does", "probability": 0.740234375}, {"start": 796.85, "end": 797.11, "word": " not", "probability": 0.96484375}, {"start": 797.11, "end": 797.65, "word": " change", "probability": 0.7978515625}, {"start": 797.65, "end": 797.99, "word": " over", "probability": 0.9111328125}, {"start": 797.99, "end": 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"seek": 83161, "start": 809.29, "end": 831.61, "text": "بيقول ان في عشر القوات ناحية theoretical diversity في الميس من class 1 و class 2 يعني هي من class 1 بيقولوا class 2 يعني أقل شوية عشر القوات عشرة polymorphism of class 1 و 8 أيضا this will serve as antigen", "tokens": [3555, 1829, 39648, 16472, 8978, 6225, 46309, 25062, 2407, 9307, 8717, 39319, 10632, 20864, 8811, 8978, 9673, 1829, 3794, 9154, 1508, 502, 4032, 1508, 568, 37495, 22653, 39896, 9154, 1508, 502, 4724, 1829, 39648, 14407, 1508, 568, 37495, 22653, 5551, 4587, 1211, 13412, 2407, 10632, 6225, 46309, 25062, 2407, 9307, 6225, 8592, 25720, 6754, 76, 18191, 1434, 295, 1508, 502, 4032, 1649, 36632, 11242, 995, 341, 486, 4596, 382, 2511, 3213], "avg_logprob": -0.3370225706862079, "compression_ratio": 1.5666666666666667, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 809.29, "end": 809.71, "word": "بيقول", "probability": 0.5582682291666666}, {"start": 809.71, "end": 809.93, "word": " ان", "probability": 0.383056640625}, {"start": 809.93, "end": 810.07, "word": " في", "probability": 0.51171875}, {"start": 810.07, "end": 810.43, "word": " عشر", "probability": 0.788330078125}, {"start": 810.43, "end": 810.87, "word": " القوات", "probability": 0.7252604166666666}, {"start": 810.87, "end": 811.11, "word": " ناحية", "probability": 0.685302734375}, {"start": 811.11, "end": 811.55, "word": " theoretical", "probability": 0.1798095703125}, {"start": 811.55, "end": 812.45, "word": " diversity", "probability": 0.9326171875}, {"start": 812.45, "end": 813.31, "word": " في", "probability": 0.75146484375}, {"start": 813.31, "end": 813.77, "word": " الميس", "probability": 0.6099446614583334}, {"start": 813.77, "end": 813.95, "word": " من", "probability": 0.6708984375}, {"start": 813.95, "end": 814.25, "word": " class", "probability": 0.7822265625}, {"start": 814.25, "end": 814.61, "word": " 1", "probability": 0.5546875}, {"start": 814.61, "end": 814.77, "word": " و", "probability": 0.97021484375}, {"start": 814.77, "end": 815.01, "word": " class", "probability": 0.5771484375}, {"start": 815.01, "end": 815.39, "word": " 2", "probability": 0.93994140625}, {"start": 815.39, "end": 817.07, "word": " يعني", "probability": 0.762451171875}, {"start": 817.07, "end": 817.31, "word": " هي", "probability": 0.155029296875}, {"start": 817.31, "end": 817.45, "word": " من", "probability": 0.681640625}, {"start": 817.45, "end": 817.69, "word": " class", "probability": 0.93310546875}, {"start": 817.69, "end": 817.99, "word": " 1", "probability": 0.892578125}, {"start": 817.99, "end": 818.53, "word": " بيقولوا", "probability": 0.7161865234375}, {"start": 818.53, "end": 818.87, "word": " class", "probability": 0.35791015625}, {"start": 818.87, "end": 819.21, "word": " 2", "probability": 0.880859375}, {"start": 819.21, "end": 819.63, "word": " يعني", "probability": 0.868896484375}, {"start": 819.63, "end": 819.93, "word": " أقل", "probability": 0.876953125}, {"start": 819.93, "end": 820.33, "word": " شوية", "probability": 0.8766276041666666}, {"start": 820.33, "end": 820.65, "word": " عشر", "probability": 0.91748046875}, {"start": 820.65, "end": 821.11, "word": " القوات", "probability": 0.8631184895833334}, {"start": 821.11, "end": 823.35, "word": " عشرة", "probability": 0.7177734375}, {"start": 823.35, "end": 827.01, "word": " polymorphism", "probability": 0.8726806640625}, {"start": 827.01, "end": 827.19, "word": " of", "probability": 0.8505859375}, {"start": 827.19, "end": 827.49, "word": " class", "probability": 0.9697265625}, {"start": 827.49, "end": 827.75, "word": " 1", "probability": 0.91162109375}, {"start": 827.75, "end": 827.97, "word": " و", "probability": 0.947265625}, {"start": 827.97, "end": 828.29, "word": " 8", "probability": 0.56787109375}, {"start": 828.29, "end": 829.39, "word": " أيضا", "probability": 0.8719075520833334}, {"start": 829.39, "end": 829.89, "word": " this", "probability": 0.69580078125}, {"start": 829.89, "end": 830.23, "word": " will", "probability": 0.89697265625}, {"start": 830.23, "end": 830.67, "word": " serve", "probability": 0.91064453125}, {"start": 830.67, "end": 830.97, "word": " as", "probability": 0.96142578125}, {"start": 830.97, "end": 831.61, "word": " antigen", "probability": 0.9267578125}], "temperature": 1.0}, {"id": 34, "seek": 86219, "start": 833.59, "end": 862.19, "text": "الـ MHC موليكيول ستعمل كانتجين لكي تسمح بإنسانك بمعرفة ما هو نفسك وما هو غير نفسك مجموعات مختلفة الاليليل تعمل ان الانتجين هو MHC موليكيول وفي كل جنس هناك الكثير من الاليليل المهم في هذا الموضوع ان هناك الكثير من الاليليل وكثير من المجموعات وبالتالي لا يمكن ان يكون هناك", "tokens": [6027, 39184, 34796, 34, 3714, 12610, 1829, 4117, 1829, 12610, 8608, 2655, 25957, 1211, 9122, 7649, 2655, 7435, 9957, 5296, 4117, 1829, 6055, 38251, 5016, 4724, 28814, 1863, 3794, 7649, 4117, 4724, 2304, 3615, 28480, 3660, 19446, 31439, 8717, 36178, 4117, 4032, 15042, 31439, 32771, 13546, 8717, 36178, 4117, 3714, 7435, 2304, 45367, 9307, 3714, 46456, 46538, 3660, 2423, 6027, 1829, 20292, 1211, 6055, 25957, 1211, 16472, 2423, 7649, 2655, 7435, 9957, 31439, 34796, 34, 3714, 12610, 1829, 4117, 1829, 12610, 4032, 41185, 28242, 10874, 1863, 3794, 34105, 4117, 33251, 12984, 13546, 9154, 2423, 6027, 1829, 20292, 1211, 9673, 16095, 8978, 23758, 9673, 2407, 11242, 45367, 16472, 34105, 4117, 33251, 12984, 13546, 9154, 2423, 6027, 1829, 20292, 1211, 4032, 4117, 12984, 13546, 9154, 9673, 7435, 2304, 45367, 9307, 46599, 6027, 2655, 6027, 1829, 20193, 7251, 43020, 16472, 7251, 30544, 34105, 4117], "avg_logprob": -0.4744718286772849, "compression_ratio": 2.276995305164319, "no_speech_prob": 0.0, "words": [{"start": 833.59, "end": 833.89, "word": "الـ", "probability": 0.3084716796875}, {"start": 833.89, "end": 834.57, "word": " MHC", "probability": 0.912841796875}, {"start": 834.57, "end": 835.51, "word": " موليكيول", "probability": 0.7450358072916666}, {"start": 835.51, "end": 836.09, "word": " ستعمل", "probability": 0.58282470703125}, {"start": 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"word": " مجموعات", "probability": 0.477978515625}, {"start": 843.49, "end": 843.75, "word": " مختلفة", "probability": 0.85235595703125}, {"start": 843.75, "end": 845.07, "word": " الاليليل", "probability": 0.3971923828125}, {"start": 845.07, "end": 846.11, "word": " تعمل", "probability": 0.8634440104166666}, {"start": 846.11, "end": 846.31, "word": " ان", "probability": 0.360595703125}, {"start": 846.31, "end": 846.93, "word": " الانتجين", "probability": 0.57178955078125}, {"start": 846.93, "end": 847.19, "word": " هو", "probability": 0.6767578125}, {"start": 847.19, "end": 847.65, "word": " MHC", "probability": 0.6710205078125}, {"start": 847.65, "end": 848.25, "word": " موليكيول", "probability": 0.9454752604166666}, {"start": 848.25, "end": 849.53, "word": " وفي", "probability": 0.486328125}, {"start": 849.53, "end": 849.87, "word": " كل", "probability": 0.833984375}, {"start": 849.87, "end": 850.65, "word": " جنس", "probability": 0.3964029947916667}, {"start": 850.65, "end": 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1917.55, "end": 1918.15, "word": " صار", "probability": 0.964111328125}, {"start": 1918.15, "end": 1918.27, "word": " في", "probability": 0.83935546875}, {"start": 1918.27, "end": 1918.61, "word": " عندها", "probability": 0.993408203125}, {"start": 1918.61, "end": 1919.43, "word": " necrotizing", "probability": 0.67120361328125}, {"start": 1919.43, "end": 1920.43, "word": " granulomatous", "probability": 0.837646484375}, {"start": 1920.43, "end": 1920.87, "word": " lesion", "probability": 0.937744140625}, {"start": 1920.87, "end": 1921.03, "word": " في", "probability": 0.884765625}, {"start": 1921.03, "end": 1921.51, "word": " منطقة", "probability": 0.9845377604166666}, {"start": 1921.51, "end": 1922.09, "word": " الأنف", "probability": 0.8850911458333334}, {"start": 1922.09, "end": 1923.69, "word": " due", "probability": 0.86962890625}, {"start": 1923.69, "end": 1923.97, "word": " to", "probability": 0.9794921875}, {"start": 1923.97, "end": 1924.37, "word": " TAB", "probability": 0.385009765625}, {"start": 1924.37, "end": 1925.11, "word": " deficiency", "probability": 0.69970703125}, {"start": 1925.11, "end": 1926.25, "word": " syndrome", "probability": 0.84375}, {"start": 1926.25, "end": 1928.59, "word": " وبهيك", "probability": 0.85595703125}, {"start": 1928.59, "end": 1928.75, "word": " ان", "probability": 0.6474609375}, {"start": 1928.75, "end": 1928.99, "word": " شاء", "probability": 0.987060546875}, {"start": 1928.99, "end": 1929.31, "word": " الله", "probability": 0.95654296875}, {"start": 1929.31, "end": 1930.69, "word": " بنكون", "probability": 0.907958984375}, {"start": 1930.69, "end": 1931.21, "word": " أنهينا", "probability": 0.83740234375}, {"start": 1931.21, "end": 1931.91, "word": " المحاضرة", "probability": 0.9732666015625}, {"start": 1931.91, "end": 1933.23, "word": " نتمنى", "probability": 0.8568115234375}, {"start": 1933.23, "end": 1933.35, "word": " أن", "probability": 0.66845703125}, {"start": 1933.35, "end": 1933.85, "word": " تكونوا", "probability": 0.9884440104166666}, {"start": 1933.85, "end": 1934.33, "word": " قد", "probability": 0.984375}, {"start": 1934.33, "end": 1935.95, "word": " استفدتم", "probability": 0.9498291015625}, {"start": 1935.95, "end": 1936.73, "word": " منها", "probability": 0.991455078125}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 1937.12475, "duration_after_vad": 1843.4243749999953} \ No newline at end of file diff --git a/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/9HiEsDjl9XE_raw.srt b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/9HiEsDjl9XE_raw.srt new file mode 100644 index 0000000000000000000000000000000000000000..6dca54e19dd783976c706a0da78a8ad5757cc4f1 --- /dev/null +++ b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/9HiEsDjl9XE_raw.srt @@ -0,0 +1,1556 @@ +1 +00:00:01,380 --> 00:00:07,080 +باسمه بنتقل اليوم في محاضرة جديدة بعنوان الـ major + +2 +00:00:07,080 --> 00:00:10,640 +histocompatibility complex and antigen + +3 +00:00:10,640 --> 00:00:17,400 +presentation ال + +4 +00:00:17,400 --> 00:00:22,260 +major histocompatibility complex هم مجموعات جينية + +5 +00:00:22,260 --> 00:00:25,620 +مرتبطة جدًا ووظيفتهم + +6 +00:00:25,620 --> 00:00:29,260 +الأساسية هو عبارة عن intracellular recognition + +7 +00:00:31,750 --> 00:00:38,510 +antigen and self-mental discrimination ويلهم مظائف + +8 +00:00:38,510 --> 00:00:43,230 +مهمة جدا في ال transplantation مسئولين عن + +9 +00:00:43,230 --> 00:00:48,630 +transplant rejection شوان كان في حالة الhistoin + +10 +00:00:48,630 --> 00:00:53,150 +compatibility كمان يلهم دور في ال humor and self + +11 +00:00:53,150 --> 00:00:59,140 +-mediated immunity ويلهم دور مهم جدافي الـ Antigen + +12 +00:00:59,140 --> 00:01:04,400 +recognition by T lymphocytes أول + +13 +00:01:04,400 --> 00:01:08,580 +من حكى في هذا الموضوع هو جورج روسنيل في 1930 في + +14 +00:01:08,580 --> 00:01:13,460 +1980 أخد نوبل برايز على هذا الموضوع ال location + +15 +00:01:13,460 --> 00:01:17,840 +جاله هذه الجينات ان ال human موجودة على كرمزوم رقم + +16 +00:01:17,840 --> 00:01:23,200 +6 و بيسموها MHC major histocompatibility complex + +17 +00:01:23,200 --> 00:01:30,580 +geneأو HLA أو human leukocyte antigen and they are + +18 +00:01:30,580 --> 00:01:35,940 +recognized in a region encoded three classes of + +19 +00:01:35,940 --> 00:01:41,040 +molecule تلت أنواع من ال MLC موجودة وهي تحت في ال + +20 +00:01:41,040 --> 00:01:47,270 +human في عنا three regionsالأولانية بيسموها region + +21 +00:01:47,270 --> 00:01:57,470 +number A ثم B ثم C و هدول التلاتة ل class 1 ثم ال + +22 +00:01:57,470 --> 00:02:02,490 +region D هي ل class 2 يبقى في أنها تلت أنواع من + +23 +00:02:02,490 --> 00:02:08,370 +MSC class molecule اللي هو class 1 و class 2 و + +24 +00:02:08,370 --> 00:02:15,400 +class 3موجودين على كرمزوم رقم ستة في موزعين في + +25 +00:02:15,400 --> 00:02:21,260 +أربع مناطق اربع four different regions دي ABC ثم D + +26 +00:02:21,260 --> 00:02:27,720 +يتوسطهم class تلاتة و for unknown reason for + +27 +00:02:27,720 --> 00:02:33,340 +unknown reason هال كرمزوم رقم ستة على الشورط أرض + +28 +00:02:33,340 --> 00:02:40,220 +كرمزوم رقم ستة اسمها HLA regionوهي مقسمة إلى تلت + +29 +00:02:40,220 --> 00:02:45,660 +تلاتة different types of genes class واحد class + +30 +00:02:45,660 --> 00:02:50,160 +اتنين class تلاتة طبعا زي ما انتوا شايفين في عندنا + +31 +00:02:50,160 --> 00:02:55,580 +gene و في صوت جين انما كلهم احنا معانيين باش ال + +32 +00:02:55,580 --> 00:02:56,560 +functional gene + +33 +00:03:00,220 --> 00:03:04,540 +وهذه طبعا صورة بتبين لي بوضوح تركيبة كل واحد منهم + +34 +00:03:04,540 --> 00:03:13,120 +هي ال A class 1 ABC بيتكون من alpha-polypeptide + +35 +00:03:13,120 --> 00:03:21,760 +linked with B2-microglobulin protein كوّن لي اللي + +36 +00:03:21,760 --> 00:03:31,750 +هو ال MHC او ال HLAرقم A هو ده بيتكوّن من تلاتة + +37 +00:03:31,750 --> 00:03:36,050 +domain لـ Alpha مع بيتته Micro Global كل واحد من + +38 +00:03:36,050 --> 00:03:43,850 +هدول اللي هو نفس التركيبة بينما class 2 بيتكوّن من + +39 +00:03:43,850 --> 00:03:53,250 +DR, DQ و DB ماشي و كل واحد منهم بيتكوّن من two + +40 +00:03:53,250 --> 00:04:00,380 +polypeptideA to region طبعاً A و B اللي فيها two + +41 +00:04:00,380 --> 00:04:03,580 +pre-peptide Alpha و Beta و اللي بيكونولي في + +42 +00:04:03,580 --> 00:04:10,080 +النهاية الـDR و الـDQ و الـDB طبعا ال Alpha و Beta + +43 +00:04:10,080 --> 00:04:14,860 +chain كل واحدة منهم زي ما انتوا شايفين تتكون من + +44 +00:04:14,860 --> 00:04:20,860 +two domain Alpha 1 و Alpha 2 و Beta 1 و Beta 2 and + +45 +00:04:20,860 --> 00:04:25,000 +they configure in a shape resemblingأو الـ + +46 +00:04:25,000 --> 00:04:29,820 +Immunoglobulin Structure هذا هو نفس الحكاية لأن + +47 +00:04:29,820 --> 00:04:32,900 +كلهم يندرجوا تحت الـ Immunoglobulin Gen + +48 +00:04:32,900 --> 00:04:38,480 +Superfamily Class I MHC Molecule هو ميدياة إيمينو + +49 +00:04:38,480 --> 00:04:41,600 +ريسبونسيه ضد الاندوجينس وظيفته يتعرف على + +50 +00:04:41,600 --> 00:04:47,320 +الاندوجينس انتجن اللي موجود في الجلد + +51 +00:05:02,430 --> 00:05:06,870 +الخلايا اللي بيصير فيها طبعا هذه الانتجينات + +52 +00:05:06,870 --> 00:05:16,880 +الداخلية اندوجنس اما viral او tumor antigen الالـ + +53 +00:05:16,880 --> 00:05:22,660 +MHC موليكول بيرتبط بـ Antigenic Peptide حجمها 8 + +54 +00:05:22,660 --> 00:05:27,860 +إلى 10 Amino Acids اللي بعد هيك تتقدم للـ + +55 +00:05:27,860 --> 00:05:34,230 +Cytotoxic T Lymphocyte اللي هي CD8ووجدوا ان ال MSC + +56 +00:05:34,230 --> 00:05:38,150 +class 1 موجود على كل خلايا الجسم وبالتالي اي خلية + +57 +00:05:38,150 --> 00:05:43,310 +بيصير فيها infection سواء virally او tumor تستطيع + +58 +00:05:43,310 --> 00:05:47,530 +ان تقدم الانتجين لساعة ال toxic تيرينفسايت تخلصنا + +59 +00:05:47,530 --> 00:05:54,270 +منه ال class 2 بيبقى اي اميون response against + +60 +00:05:54,270 --> 00:05:57,930 +exogenous انتجان الانتجانات القارجية اللي موجودين + +61 +00:05:57,930 --> 00:06:05,720 +برا الخليةو Class II يرتبط بـ Peptide حجمها 13 لـ + +62 +00:06:05,720 --> 00:06:10,580 +18 Amino Acids in size that are presented to T + +63 +00:06:10,580 --> 00:06:15,420 +-Helper cell and recognized by it الـ MHC Class II + +64 +00:06:15,420 --> 00:06:19,860 +موجود على خلايا محددة مش على كل خلايا الجسم موجود + +65 +00:06:19,860 --> 00:06:23,580 +على الـ P-Lymphocytes على الـ Macrophageعالـ + +66 +00:06:23,580 --> 00:06:27,140 +Monocyte, Dendritic Cell وIndothelial Cells واذا + +67 +00:06:27,140 --> 00:06:31,600 +لاحظنا ان هذه الخلايا هي عبارة عن Antigen + +68 +00:06:31,600 --> 00:06:38,060 +Presenting Cell هذين فجوسيتيك ويمكن انه يدخل + +69 +00:06:38,060 --> 00:06:42,900 +بسهولة الـ Extracellular Antigen Class III زي ما + +70 +00:06:42,900 --> 00:06:49,320 +قلنالكوا ليس لديه رول في الانتجين برزنتيشن لكنه + +71 +00:06:49,320 --> 00:06:52,200 +يتكود لسكريت البروتين + +72 +00:06:56,360 --> 00:07:01,160 +من خلال البروسيس الدينية وجوده ما بين class 1 و + +73 +00:07:01,160 --> 00:07:06,800 +class 2 هو غير متأكد بمعناه مش محروف او مش مؤكد + +74 +00:07:06,800 --> 00:07:11,020 +لما + +75 +00:07:11,020 --> 00:07:18,160 +تشوف هبلو تايب جاله كل ستة جينات موجودة على سنك + +76 +00:07:18,160 --> 00:07:24,510 +الكرومزومماشي set of genes بيسموها haplotype يبقى + +77 +00:07:24,510 --> 00:07:28,990 +ال haplotype هي برعنة set of gene ل class واحد و + +78 +00:07:28,990 --> 00:07:32,070 +set of gene ل class اتنين مرتبطين على one + +79 +00:07:32,070 --> 00:07:35,530 +chromosome وجودين على chromosome واحد اللي هو رقم + +80 +00:07:35,530 --> 00:07:41,610 +ستة و كلهم collectively are known as haplotype و + +81 +00:07:41,610 --> 00:07:44,550 +ال individual عنده two haplotype واحد جاي من ال + +82 +00:07:44,550 --> 00:07:49,350 +maternal واحد جاي من ال paternalوهذه الجينات + +83 +00:07:49,350 --> 00:07:56,530 +موصولة معايا يعني يورثوا مع بعض مادية ومادية + +84 +00:07:56,530 --> 00:08:04,810 +برودكت موصولة في نفس الجسيم.الكلاس وان الستركترات + +85 +00:08:04,810 --> 00:08:09,770 +التي اتفقنا بها تكوين من الفا، عبارة عن عبارة عن + +86 +00:08:09,770 --> 00:08:14,770 +عبارة عن عبارة عن عبارة عن عبارة عن عبارة عنوالـ + +87 +00:08:14,770 --> 00:08:17,170 +Alpha هي عبارة عن Polymorphic Transmembraic + +88 +00:08:17,170 --> 00:08:22,510 +Lycoprotein بيتكوّن من three domain بيتكوّن مناشر + +89 +00:08:22,510 --> 00:08:27,250 +three domain Alpha 1, Alpha 2, Alpha 3 مرتبطة بال + +90 +00:08:27,250 --> 00:08:30,970 +Beta 2-microlipid وعبارة عن invariant protein + +91 +00:08:30,970 --> 00:08:38,670 +encoded by a gene on a different chromosomeطبعا ال + +92 +00:08:38,670 --> 00:08:44,110 +association بين Alpha و Beta 2 microglobulin مطلوب + +93 +00:08:44,110 --> 00:08:50,810 +جدا for the expression class I on cell membrane و + +94 +00:08:50,810 --> 00:08:56,730 +ده هو أي Alpha يتكوّن من ثلاثة دومين Alpha 1 Alpha + +95 +00:08:56,730 --> 00:09:02,370 +2 Alpha 3 مرتبطة ب Beta 2 microglobulinالجزء + +96 +00:09:02,370 --> 00:09:08,030 +البراني اللي هو extra cellular ده هو براني three + +97 +00:09:08,030 --> 00:09:14,210 +اللي هو عبارة عن invariant chains بمعنى هي عبارة + +98 +00:09:14,210 --> 00:09:22,250 +عن variable و ال peptide بيرتبط في هذه المنطقة + +99 +00:09:22,250 --> 00:09:29,220 +باسمها peptide cleft او peptide binding growthماشي + +100 +00:09:29,220 --> 00:09:35,100 +Alpha 3 و Beta 2 microglobulin are constant region + +101 +00:09:35,100 --> 00:09:44,680 +و CD8 بيرتبط غالبا بال Alpha 3 بيرتبط بال Alpha 3 + +102 +00:09:44,680 --> 00:09:50,440 +ال molecule أيضا فيه Trans membrane و فيه short + +103 +00:09:50,440 --> 00:09:56,950 +cytoplasmic tailstructure collectively زي ما انتوا + +104 +00:09:56,950 --> 00:10:06,010 +شايفين resembling immunoglobulin in shape and even + +105 +00:10:06,010 --> 00:10:11,850 +structure بينما ال class two structure بتتكون من + +106 +00:10:11,850 --> 00:10:15,770 +two polyp بتاعة واحدة Alpha واحدة Beta وكل واحدة + +107 +00:10:15,770 --> 00:10:19,430 +بتتكون من two domain Alpha one Alpha twoوبيتا وان + +108 +00:10:19,430 --> 00:10:26,230 +وبيتا تو ايضا ال antigen binding موجود بين الفا + +109 +00:10:26,230 --> 00:10:31,110 +واحد وبيتا واحد مرانيو كما تشاهدين الانتجينيك + +110 +00:10:31,110 --> 00:10:37,550 +بيبتعد شويه اكبر وبالتالي بيستطي بعاد شويه عن بعض + +111 +00:10:37,550 --> 00:10:45,470 +بالتالي بيرتبطوا بانتجينيك بيبتعد شويه اكبر ماشي + +112 +00:10:45,470 --> 00:10:50,070 +ايضا له Transmembrane and cytoplasmic tail + +113 +00:10:57,020 --> 00:11:00,100 +بالمناسبة Alpha 1 Beta 1 هي عبارة عن الـ Variable + +114 +00:11:00,100 --> 00:11:03,180 +و Alpha 2 Beta 2 هي عبارة عن الـ Concentration + +115 +00:11:03,180 --> 00:11:09,380 +وهذا الجدول يظهر الفروقات بين Class 1 و Class 2 + +116 +00:11:09,380 --> 00:11:15,740 +يتكوّن من Alpha 1 Alpha 2 إلى Alpha 1 Beta 1 + +117 +00:11:15,740 --> 00:11:21,320 +لمنطقة الأرتباط بالـ Antigenطبعا هذه المنطقة مسكرة + +118 +00:11:21,320 --> 00:11:26,420 +في class 1 لكنها مفتوحة في class 2 ف ال size of + +119 +00:11:26,420 --> 00:11:32,860 +peptide 18 شوية صغير لكنها من 13 ل 18 لأنها مفتوحة + +120 +00:11:32,860 --> 00:11:38,520 +و أكبر ال peptide motif anchor residue at both + +121 +00:11:38,520 --> 00:11:45,040 +ends of peptide and generally hydrophobic carboxyl + +122 +00:11:45,040 --> 00:11:48,750 +terminal اللي بيبقوا طلعةهذه نفس الحكاية Anchor + +123 +00:11:48,750 --> 00:11:52,030 +residue distributed along the length of the + +124 +00:11:52,030 --> 00:11:58,870 +peptide على طول الـpeptide initial and bound هذا + +125 +00:11:58,870 --> 00:12:05,130 +بيرتبط بان الانتصارين + +126 +00:12:05,130 --> 00:12:07,230 +يتعامل مع عمق الشيخ اليسار + +127 +00:12:10,160 --> 00:12:16,280 +وهذا اتسلب at a constant elevation above the floor + +128 +00:12:16,280 --> 00:12:24,880 +of MHC cleft MHC + +129 +00:12:24,880 --> 00:12:29,780 +class 1 per class 2 peptide interaction طبعا ترتبط + +130 +00:12:29,780 --> 00:12:33,400 +بالpeptide and presented to CD4 T-Helper cell and + +131 +00:12:33,400 --> 00:12:38,650 +it can bind to a variety of peptideوبتعمل + +132 +00:12:38,650 --> 00:12:41,930 +Indocytic Processing Pathway نتعرف عليه قدام + +133 +00:12:41,930 --> 00:12:47,710 +Polymorphism of class 1 و2 قالوا ال polymorphism + +134 +00:12:47,710 --> 00:12:51,450 +هو عبارة عن ال presence of multiple alleles at a + +135 +00:12:51,450 --> 00:12:57,030 +given genetic locus within a species ووجدوا انه at + +136 +00:12:57,030 --> 00:13:03,110 +class 1 و class 2 there areفي هذه المناطق علشان هي + +137 +00:13:03,110 --> 00:13:09,470 +Polymorphism Polymorphic جين Diversity of MHC + +138 +00:13:09,470 --> 00:13:14,350 +within a species results from this polymorphism و + +139 +00:13:14,350 --> 00:13:17,650 +ال MHC expressed by individual does not change + +140 +00:13:17,650 --> 00:13:22,690 +over the time لكن فيه different significantly + +141 +00:13:22,690 --> 00:13:29,930 +between individual within the same speciesبيقول ان + +142 +00:13:29,930 --> 00:13:33,770 +في عشر القوات ناحية theoretical diversity في الميس + +143 +00:13:33,770 --> 00:13:38,530 +من class 1 و class 2 يعني هي من class 1 بيقولوا + +144 +00:13:38,530 --> 00:13:47,010 +class 2 يعني أقل شوية عشر القوات عشرة polymorphism + +145 +00:13:47,010 --> 00:13:53,890 +of class 1 و 8 أيضا this will serve as antigenالـ + +146 +00:13:53,890 --> 00:13:59,470 +MHC موليكيول ستعمل كانتجين لكي تسمح بإنسانك بمعرفة + +147 +00:13:59,470 --> 00:14:05,070 +ما هو نفسك وما هو غير نفسك مجموعات مختلفة الاليليل + +148 +00:14:05,070 --> 00:14:12,050 +تعمل ان الانتجين هو MHC موليكيول وفي كل جنس هناك + +149 +00:14:12,050 --> 00:14:16,490 +الكثير من الاليليل المهم في هذا الموضوع ان هناك + +150 +00:14:16,490 --> 00:14:21,430 +الكثير من الاليليل وكثير من المجموعات وبالتالي لا + +151 +00:14:21,430 --> 00:14:22,190 +يمكن ان يكون هناك + +152 +00:14:28,320 --> 00:14:33,060 +لكن عملية الترانسبلانتيشن ليست مستحيلة اليوم يوجد + +153 +00:14:33,060 --> 00:14:39,360 +ألف عضلات من عضلات ترانسبلانتيشن كل عام ونتطلع + +154 +00:14:39,360 --> 00:14:45,920 +لهذا الموضوع في عرض ترانسبلانتيشن Class III هم + +155 +00:14:45,920 --> 00:14:48,160 +مجموعات مختلفة ومستعمرة ومفتوحة ومستعمرة ومستعمرة + +156 +00:14:48,160 --> 00:14:48,980 +ومستعمرة ومستعمرة ومستعمرة ومستعمرة ومستعمرة + +157 +00:14:48,980 --> 00:14:50,360 +ومستعمرة ومستعمرة ومستعمرة ومستعمرة ومستعمرة + +158 +00:14:50,360 --> 00:14:51,000 +ومستعمرة ومستعمرة ومستعمرة ومستعمرة ومستعمرة + +159 +00:14:51,000 --> 00:14:51,220 +ومستعمرة ومستعمرة ومستعمرة ومستعمرة ومستعمرة + +160 +00:14:51,220 --> 00:14:56,570 +ومستعمرة ومستعمرة ومستعمرة وهم يحتوي على مجموعات + +161 +00:14:56,570 --> 00:14:59,810 +متشابهة مختلفة مثل الـ Human Necrosis Factor أو + +162 +00:14:59,810 --> 00:15:01,230 +الـ Heat Shock Protein أو الـ Heat Shock Protein + +163 +00:15:01,230 --> 00:15:02,130 +أو الـ Heat Shock Protein أو الـ Heat Shock + +164 +00:15:02,130 --> 00:15:06,310 +Protein أو الـ Heat + +165 +00:15:06,310 --> 00:15:06,430 +Shock Protein أو الـ Heat Shock Protein أو الـ + +166 +00:15:06,430 --> 00:15:08,810 +Heat Shock Protein أو الـ Heat Shock Protein أو + +167 +00:15:08,810 --> 00:15:12,010 +الـ Heat Shock Protein أو الـ Heat Shock Protein + +168 +00:15:12,010 --> 00:15:12,070 +أو الـ Heat Shock Protein أو الـ Heat Shock + +169 +00:15:12,070 --> 00:15:12,070 +Protein أو الـ Heat Shock Protein أو الـ Heat + +170 +00:15:12,070 --> 00:15:12,070 +Shock Protein أو الـ Heat Shock Protein أو الـ + +171 +00:15:12,070 --> 00:15:12,070 +Heat Shock Protein أو الـ Heat Shock Protein أو + +172 +00:15:12,070 --> 00:15:12,090 +الـ Heat Shock Protein أو الـ Heat Shock Protein + +173 +00:15:12,090 --> 00:15:12,090 +أو الـ Heat Shock Protein أو الـ Heat Shock + +174 +00:15:12,090 --> 00:15:12,870 +Protein أو الـ Heat Shock Protein أو الـ Heat + +175 +00:15:12,870 --> 00:15:16,370 +Shock Protein أو الـ Heat Shock Protein أو الـ + +176 +00:15:16,370 --> 00:15:21,610 +Heat Shock Protein أو الـ Heat Shock + +177 +00:15:21,610 --> 00:15:23,910 +Protein أو الـ Heat Shock Protein أو الـ Heat + +178 +00:15:23,910 --> 00:15:27,710 +Shock Proteهيلي كونزيرف دي بروتين بينوجد فيه فيه + +179 +00:15:27,710 --> 00:15:36,650 +اوقات غير طبيعية وفي محفزات كثيرة لإنتاج ذو سيد شك + +180 +00:15:36,650 --> 00:15:41,830 +بروتين ماشي منها على سبيل المثال الـ nutrient + +181 +00:15:41,830 --> 00:15:45,930 +deprivation مجععات اكسجين راديكال and viral + +182 +00:15:45,930 --> 00:15:52,410 +infection كل عبارة عن محفزات لخيكشك بروتين + +183 +00:15:52,410 --> 00:15:56,010 +productionوهي مرتبطة بشكل عام بشكل عام بشكل عام + +184 +00:15:56,010 --> 00:15:58,170 +بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل + +185 +00:15:58,170 --> 00:16:01,070 +عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام + +186 +00:16:01,070 --> 00:16:02,850 +بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل + +187 +00:16:02,850 --> 00:16:03,930 +عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام + +188 +00:16:03,930 --> 00:16:04,770 +بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل + +189 +00:16:04,770 --> 00:16:08,050 +عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام + +190 +00:16:08,050 --> 00:16:08,050 +بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل + +191 +00:16:08,050 --> 00:16:12,920 +عام بشكل عام بprocessing and presentation هذه + +192 +00:16:12,920 --> 00:16:16,040 +مصطلحين عندنا ال processing هي عبارة عن عملية + +193 +00:16:16,040 --> 00:16:21,960 +تجهيز وتشجيف وتقطيع ال antigen ماشي بسموها + +194 +00:16:21,960 --> 00:16:25,800 +processing و ال presentation هي عبارة عن عملية + +195 +00:16:25,800 --> 00:16:29,180 +تقديم ال antigen بيرتبط من MSH مليكيول على سطح + +196 +00:16:29,180 --> 00:16:34,680 +الخلية و بيتقدم لمين ل T cell يبقى ال processing + +197 +00:16:34,680 --> 00:16:39,730 +هو عبارة عن عملية ايهاش ال degradationof antigen + +198 +00:16:39,730 --> 00:16:47,330 +into peptide و ال presentation هو عبارة عن تقديم + +199 +00:16:47,330 --> 00:16:55,910 +هذا ال antigen ل T cell ال class I برتبط موليكيوه + +200 +00:16:55,910 --> 00:16:59,530 +طبعا عملشي موليكيوه بايد بيبتايد derived from + +201 +00:16:59,530 --> 00:17:00,250 +endogenous + +202 +00:17:03,260 --> 00:17:06,260 +هذا الانتجن الاندوجيني يمكن ان يتم تصميمه في + +203 +00:17:06,260 --> 00:17:10,440 +الانسان والسيطابلزام بينما الكلاس 2 يرتبط بانتجن + +204 +00:17:10,440 --> 00:17:15,180 +اكسوجيني يعني جاية من برا انتجنيا بفاجوسيتوسيا او + +205 +00:17:15,180 --> 00:17:19,880 +اندوستيتوسيا بسرعة التصميم الاندوستيكي التي + +206 +00:17:19,880 --> 00:17:25,430 +سنشاهدها الآنبما أننا ندخل في عملية الـ Processing + +207 +00:17:25,430 --> 00:17:28,950 +و الـ Presentation نريد أن نأكد على عملية الـ MHC + +208 +00:17:28,950 --> 00:17:32,450 +أو Self-MHC Restriction بمعنى أن الـ T-Lymphocyte + +209 +00:17:32,450 --> 00:17:38,190 +لا تتعامل إلا مع MHC مليكيول شافته قبل هيك within + +210 +00:17:38,190 --> 00:17:42,210 +the same species وين في الـ Thymus مش تقدملها و هي + +211 +00:17:42,210 --> 00:17:48,150 +بتتعلم و تتدرب وبالتالي ما لا تتعامل مع MHC from + +212 +00:17:48,150 --> 00:17:51,390 +other individual + +213 +00:17:53,210 --> 00:17:59,430 +طبعا في اتنين علماء ده هم زي انجرنيجل ودوارتي + +214 +00:17:59,430 --> 00:18:07,290 +عملوا تجربة ليسبب تقول ذلك فراحوا ايش عملوا ده هي + +215 +00:18:07,290 --> 00:18:13,490 +طبعا دي اللي هو التجربة خلينا نشوفها ده هو جابوا + +216 +00:18:13,490 --> 00:18:22,010 +فار وحقنوه ب ال ال CM ال virus اللي هو ال + +217 +00:18:24,930 --> 00:18:33,730 +Lymphocyte Chorium meningitis virus وبعد + +218 +00:18:33,730 --> 00:18:39,770 +أسبوعين أخدوا خلايا من الـSpleen هذه الخلايا تحتوي + +219 +00:18:39,770 --> 00:18:48,170 +على T-cytotoxic وهي بتكون Alliard يعني جاهزة للتأ + +220 +00:18:48,170 --> 00:18:55,400 +للقتل ثم عملوا incubation لهذه الخلايامع target + +221 +00:18:55,400 --> 00:19:06,600 +cell من اللي هو نفس الفار لكن هو مش infected و مع + +222 +00:19:06,600 --> 00:19:11,720 +نفس الفار لكن الخلايا تبعته infected و مع فار من + +223 +00:19:11,720 --> 00:19:18,520 +نوع تاني و طبعا ال antigen is already labeled by + +224 +00:19:18,520 --> 00:19:24,400 +groupوطلعوا على النتيجة وجهوا انه في ال not + +225 +00:19:24,400 --> 00:19:29,940 +infected cell ماصللهاش اشي و ال infected cell من + +226 +00:19:29,940 --> 00:19:35,840 +نفس الفار اي 2K H2K وهي الفار H2K من نفس الفار + +227 +00:19:35,840 --> 00:19:41,680 +صللها license بينما اللي اجت من الفار تاني هي 2B + +228 +00:19:41,680 --> 00:19:45,200 +there is no license بمعنى لم تتعرف عليها ولم + +229 +00:19:45,200 --> 00:19:55,520 +تعجبها ماشييعني لو حطناها في part تاني لن + +230 +00:19:55,520 --> 00:19:59,520 +تترف على اللي هو الأمشي موليكيولو تبعها + +231 +00:20:02,540 --> 00:20:06,740 +الـ Self-restriction طبعا لـ CD4 و CD8 احنا قلنا + +232 +00:20:06,740 --> 00:20:16,640 +لجيتها لـ CT cytotoxic خدنا نشوف تجربة عندهم لCD4 + +233 +00:20:16,640 --> 00:20:21,900 +طبعا جابوا two strain لكن الـ strain هدول هجين + +234 +00:20:21,900 --> 00:20:31,520 +ماشي من الخنازير strain 2 و 13 واحد strain 2 و 13 + +235 +00:20:32,110 --> 00:20:36,570 +عرضوا لواحد اعطوا واحد antigen واستنوا سبع ايام + +236 +00:20:36,570 --> 00:20:41,210 +وراحوا على الانفنوس لو بوها كبرت فاخدوا منها ال + +237 +00:20:41,210 --> 00:20:45,270 +macro phage فدل حالة ال macro phage هي عبارة عن ال + +238 +00:20:45,270 --> 00:20:49,130 +yard cell هتاخد ال antigen هتاخد ال antigen + +239 +00:20:49,130 --> 00:20:53,330 +المجموعة + +240 +00:20:53,330 --> 00:20:58,930 +التانية اللي هي برضه نفس انواع ال strains أخدتوا + +241 +00:20:58,930 --> 00:21:00,690 +من ال peritoneal exudate cell + +242 +00:21:03,940 --> 00:21:13,880 +وعملوها طبعاً اديرانس في petri dish وبعد ذلك اخذوا + +243 +00:21:13,880 --> 00:21:18,180 +ال peritoneal macrophage وعرضوها ل antigen + +244 +00:21:18,180 --> 00:21:24,620 +وبالتالي صارت antigen presenting cell يبقى هنا هي + +245 +00:21:24,620 --> 00:21:29,380 +برهان خلية اخدوا T lymphocyte من هنا sorry antigen + +246 +00:21:29,380 --> 00:21:30,280 +prime T cell + +247 +00:21:33,180 --> 00:21:39,860 +أخذوا الـ T lymphocytes من الـ lymph nodes اللي هي + +248 +00:21:39,860 --> 00:21:44,440 +CD4 وهنا حضروا اللي هو الـ antigen presenting cell + +249 +00:21:44,440 --> 00:21:49,380 +والثانيين حضروهم يعني they add to each other all + +250 +00:21:49,380 --> 00:21:55,960 +of them and they culture media طبعا النتائج قالوا + +251 +00:21:55,960 --> 00:21:59,580 +لما حطينا stream 2 + +252 +00:22:02,290 --> 00:22:08,950 +T Cell من Strain 2 مع Antigen Presenting Cell من + +253 +00:22:08,950 --> 00:22:14,070 +Strain 2 صار فيه تفاعل أيه وزده لكن لما صار لما + +254 +00:22:14,070 --> 00:22:19,850 +حطناها مع Strain 13 ماصار و لما حطناها مع الهجين + +255 +00:22:19,850 --> 00:22:28,950 +اللي هو 8 و 13 صار نفس الحكاية بالنسبة لـ 13مع + +256 +00:22:28,950 --> 00:22:34,230 +strain 2 ماصار اجتفاع مع strain 13 صار مع الهجين + +257 +00:22:34,230 --> 00:22:40,870 +ايضا صار strain الهجين ده هو اللي لما حطينا الخلية + +258 +00:22:40,870 --> 00:22:45,730 +الهجين تيليمفوسايت من ال strain الهجين حطيناها مع + +259 +00:22:45,730 --> 00:22:55,740 +strain 2 و strain 13 و strainو لا جين كلها ماتت + +260 +00:22:55,740 --> 00:23:01,460 +اللي هو التفاعل دليل على ان ال antigen present او + +261 +00:23:01,460 --> 00:23:05,700 +ال T-lymphocyte لها تتعرف على انتجن مرتبط ب MSC + +262 +00:23:05,700 --> 00:23:10,180 +ملكيول from the same species + +263 +00:23:10,180 --> 00:23:15,630 +from the same individual of the same speciesطيب + +264 +00:23:15,630 --> 00:23:18,850 +انتجين presenting cell يعني انتجين presenting cell + +265 +00:23:18,850 --> 00:23:22,870 +زي ما اتفقناها اما ال c class واحد موجود على كل + +266 +00:23:22,870 --> 00:23:25,990 +خلايا الجسم ويوم تصير infected بيسموها target cell + +267 +00:23:25,990 --> 00:23:31,310 +بينما اما ال c class 2 موجود على ايش على certain + +268 +00:23:31,310 --> 00:23:31,830 +cell + +269 +00:23:34,680 --> 00:23:40,000 +وقسمهم إلى الـ Antigen Presenting Cell وقسم مشكلة + +270 +00:23:40,000 --> 00:23:44,120 +خلايا الجسم وقسمهم إلى نوعين Professional Antigen + +271 +00:23:44,120 --> 00:23:46,060 +Presenting Cell وهي عبارة عن الـ Dendritic Cell + +272 +00:23:46,060 --> 00:23:49,320 +وMacrophage B Cell وNon Professional باقي الخلايا + +273 +00:23:49,320 --> 00:23:51,980 +اللي احنا حكينا عنها زي الـ Fibroblast, Glial و + +274 +00:23:51,980 --> 00:23:58,300 +Pancreatic Cell اللي موجودة في أماكن مختلفة ال + +275 +00:23:58,300 --> 00:24:01,080 +processing زي ما قلنا في عندنا ال extra cellular + +276 +00:24:01,080 --> 00:24:02,140 +او ال extragenous + +277 +00:24:14,230 --> 00:24:17,270 +انتجن انتجن انتجن انتجن انتجن انتجن انتجن انتجن + +278 +00:24:17,270 --> 00:24:17,630 +انتجن انتجن انتجن انتجن انتجن انتجن انتجن انتجن + +279 +00:24:17,630 --> 00:24:18,950 +انتجن انتجن انتجن انتجن انتجن انتجن انتجن انتجن + +280 +00:24:18,950 --> 00:24:21,810 +انتجن انتجن انتجن انتجن انتجن انتجن انتجن انتجن + +281 +00:24:21,810 --> 00:24:22,570 +انتجن انتجن انتجن انتجن انتجن انتجن انتجن انتجن + +282 +00:24:22,570 --> 00:24:23,210 +انتجن انتجن انتجن انتجن انتجن انتجن انتجن انتجن + +283 +00:24:23,210 --> 00:24:23,210 +انتجن انتجن انتجن انتجن انتجن انتجن انتجن انتجن + +284 +00:24:34,250 --> 00:24:37,150 +الأنتيجن برزانتيج سيل بتاخد الانتيجن اما by + +285 +00:24:37,150 --> 00:24:44,030 +phagocytosis او اندو سايتوسيز متى ما اخدت الانتيجن + +286 +00:24:44,030 --> 00:24:47,150 +طبعا ال micro facial بتاع مابتشتغل بجهتين لكن + +287 +00:24:47,150 --> 00:24:53,110 +بيليب فصعد بس بتاخد الانتيجن by اندو سايتوسيز بيخش + +288 +00:24:53,110 --> 00:24:58,380 +الانتيجن جوا بيبدأ يسرله degradationationطبعاً + +289 +00:24:58,380 --> 00:25:02,400 +عملية تأخذ عامة ثلاث ساعات من ساعة على ثلاث ساعات + +290 +00:25:02,400 --> 00:25:07,360 +عشان يكتمل و يطلع ال MSC موليكيول مرتبط بال class + +291 +00:25:07,360 --> 00:25:12,600 +2 MSC موليكيول مرتبط بالانتيجن ال internalized + +292 +00:25:12,600 --> 00:25:18,540 +antigen ده هي الحكاية وببساطة هي مشروحة فهي ال + +293 +00:25:18,540 --> 00:25:25,640 +antigen طبعا مرتبطة ده هو بال receptor دخل هو + +294 +00:25:25,640 --> 00:25:29,030 +عبارة عن antibodyفي physical بيسموها clathrin + +295 +00:25:29,030 --> 00:25:36,150 +-coated physical في ال .. في هذه ال physical ماشي + +296 +00:25:36,150 --> 00:25:44,270 +بيصير في sudden drop لل .. اللي هو لل pH فبصير في + +297 +00:25:44,270 --> 00:25:50,270 +release .. release للأنتجةوبفلة اللي هو ال + +298 +00:25:50,270 --> 00:25:53,870 +receptor اللي برجع تاني ال receptor مرة تانية على + +299 +00:25:53,870 --> 00:25:59,010 +ال surface بينما ال antigen صار في داخل ال vesicle + +300 +00:25:59,010 --> 00:26:04,110 +ال vesicle ها دي بيتمر في عدة أداء بعتبروها اللي + +301 +00:26:04,110 --> 00:26:08,910 +هو early endosome ثم بتنتقل إلى مرحلة تانية اللي + +302 +00:26:08,910 --> 00:26:10,670 +هي عبارة عن late endosome + +303 +00:26:13,090 --> 00:26:18,190 +ماشي في ال Indoplasmic reticulum في مكان آخر من + +304 +00:26:18,190 --> 00:26:23,190 +الخلية بيتم تصنيع اللي هو ال MSC موليكيول بيتصنع + +305 +00:26:23,190 --> 00:26:27,190 +بيروح الجولجيا أبراطس بيطلع من الجولجيا أبراطس + +306 +00:26:27,190 --> 00:26:30,870 +انها physical و أثناء عركة الخلية two physical + +307 +00:26:30,870 --> 00:26:35,710 +fused together و بيكونوا one physical فبصير ال + +308 +00:26:35,710 --> 00:26:39,930 +physical اللي متكونت هي عبارة عن physical فيها MSC + +309 +00:26:39,930 --> 00:26:48,860 +موليكيول و أنتجلطبعا في هذه الحالة الليزوزوم + +310 +00:26:48,860 --> 00:26:51,800 +يدخل ويعمل degradation ويشجف على ال sugar في صغيرة + +311 +00:26:51,800 --> 00:26:59,600 +ويشجف على ال sugar + +312 +00:26:59,600 --> 00:27:02,200 +في صغيرة ويشجف على ال sugar في صغيرة ويشجف على ال + +313 +00:27:02,200 --> 00:27:03,220 +sugar في صغيرة ويشجف على ال sugar في صغيرة ويشجف + +314 +00:27:03,220 --> 00:27:03,220 +على ال sugar في صغيرة ويشجف على ال sugar في صغيرة + +315 +00:27:03,220 --> 00:27:04,200 +ويشجف على ال sugar في صغيرة ويشجف على ال sugar في + +316 +00:27:04,200 --> 00:27:04,280 +صغيرة ويشجف على ال sugar في صغيرة ويشجف على ال + +317 +00:27:04,280 --> 00:27:04,920 +sugar في صغيرة ويشجف على ال sugar في صغيرة ويشجف + +318 +00:27:04,920 --> 00:27:06,340 +على ال sugar في صغيرة ويشجف على ال sugar في صغيرة + +319 +00:27:06,340 --> 00:27:07,120 +ويشجف على ال sugar في صغيرة ويشجف على ال sugar في + +320 +00:27:07,120 --> 00:27:11,400 +صغيرة ويشجف على ال sugar + +321 +00:27:15,340 --> 00:27:21,100 +هذه العملية مرة تانية واضحة بكتيريا دخلت خدناها + +322 +00:27:21,100 --> 00:27:28,120 +باي اللي هو ana endocytosis اتكونت physical دخلت + +323 +00:27:28,120 --> 00:27:32,460 +فيها ال isosome كسرتها في مكان اخر من الخلية بتصنع + +324 +00:27:32,460 --> 00:27:37,240 +ال endoclamestic molecule بيروح بعد هي كترين + +325 +00:27:37,240 --> 00:27:41,900 +بيرتبط و اطلع برا هو في رحله على ال cell membrane + +326 +00:27:41,900 --> 00:27:44,020 +ان ال endoclamestic molecule بيطلع على ال cell + +327 +00:27:44,020 --> 00:27:49,020 +membraneماشي فبطلع هو في رهبته بطلع في physical + +328 +00:27:49,020 --> 00:27:52,420 +بضرب في ال physical التاني و بيكونوا physical + +329 +00:27:52,420 --> 00:27:56,620 +واحدة ده هي بيسموها phagolisosome و طبعا بيصير + +330 +00:27:56,620 --> 00:28:02,700 +عملية degradation ل اللي هو ال peptides antigenic + +331 +00:28:02,700 --> 00:28:08,480 +peptide و بترتبط محل ال peptide البديلة اللي كانت + +332 +00:28:08,480 --> 00:28:11,640 +طالعة بالامر السيمونكيول و ما بيطلع مرتبط بال + +333 +00:28:11,640 --> 00:28:13,120 +antigen ده هو السلمة + +334 +00:28:17,000 --> 00:28:21,780 +هذا الـ Exogenous و طوى شرحناه الاندوجنس يعني + +335 +00:28:21,780 --> 00:28:26,280 +الانتيجن في داخل الخلية في داخل الخلية ده هو + +336 +00:28:26,280 --> 00:28:31,980 +الانتيجن اندوجنس انتيجن بسله degradation by + +337 +00:28:31,980 --> 00:28:36,120 +proteasome هو فيه في الخلايا already proteasome + +338 +00:28:36,120 --> 00:28:43,920 +بمقاسات مختلفة المهم الانتيجن بسله degradationوبعد + +339 +00:28:43,920 --> 00:28:50,000 +ذلك الـ Endogenous Antigen يدخل على الـ + +340 +00:28:50,000 --> 00:28:56,920 +Endoplasmic reticulum من خلال تاب بروتين تاب + +341 +00:28:56,920 --> 00:29:01,880 +اختصار ل Transporter Associated Protein + +342 +00:29:04,190 --> 00:29:06,470 +فبيخششوا على الـ endoplasmic reticulum و احنا + +343 +00:29:06,470 --> 00:29:09,490 +عارفين ان في الـ endoplasmic reticulum بيتصنع ال + +344 +00:29:09,490 --> 00:29:13,650 +MSC class I مليكيول فهو بيتصنع already على طول + +345 +00:29:13,650 --> 00:29:17,550 +بيصير فيه عملية binding للـ antigen بيعيش بال MSC + +346 +00:29:17,550 --> 00:29:20,890 +مليكيول فبوضع على ال Eclipse بعدها بيطلع برا + +347 +00:29:20,890 --> 00:29:26,530 +وينتقل على ال cell membrane مرتبط بالMSC مليكيول + +348 +00:29:26,530 --> 00:29:29,750 +ال + +349 +00:29:29,750 --> 00:29:33,730 +Indigenousبنبدأ بشريح الكلام اللي تتواحى هنا بشريح + +350 +00:29:33,730 --> 00:29:36,630 +الكلام اللي تتواحى هنا بشريح الكلام اللي تتواحى + +351 +00:29:36,630 --> 00:29:40,110 +هنا بشريح الكلام اللي تتواحى هنا بشريح الكلام اللي + +352 +00:29:40,110 --> 00:29:41,890 +تتواحى هنا بشريح الكلام اللي تتواحى هنا بشريح + +353 +00:29:41,890 --> 00:29:42,670 +الكلام اللي تتواحى هنا بشريح الكلام اللي تتواحى + +354 +00:29:42,670 --> 00:29:44,330 +هنا بشريح الكلام اللي تتواحى هنا بشريح الكلام اللي + +355 +00:29:44,330 --> 00:29:46,130 +تتواحى هنا بشريح الكلام اللي تتواحى هنا بشريح + +356 +00:29:46,130 --> 00:29:53,910 +الكلام اللي تتواحى هنا بشريح الكلام اللي تتواحى + +357 +00:29:53,910 --> 00:29:58,550 +هنا بشريح الكلام اللي تتواحى هنا بشريح الكلام اللي + +358 +00:29:58,550 --> 00:30:03,830 +تCytosolic نفس الحكاية بس كل ما هناك ان الاندوجنس + +359 +00:30:03,830 --> 00:30:08,450 +انتجن بيصير له labeling بيصير له ubiquitination + +360 +00:30:08,450 --> 00:30:15,310 +بيصير ubiquitin مرتبط بالبروتين ال conjugate ده هو + +361 +00:30:15,770 --> 00:30:20,850 +بتعرف عليه البراتيوزون هو بيشكفه إلى قطع صغيرة + +362 +00:30:20,850 --> 00:30:26,590 +بيسموها low molecular mass polypeptide هدا هو + +363 +00:30:26,590 --> 00:30:31,490 +cytosolic هي ال indigenous antigen بيهي برا عن + +364 +00:30:31,490 --> 00:30:35,250 +active process بيعيب ال quetination هدا هو بتحول + +365 +00:30:35,250 --> 00:30:39,210 +إلى labelledبيتعرف عليه البروتيوزوم بشكفه + +366 +00:30:39,210 --> 00:30:43,750 +الابيبتايد ثم بعد ذلك بيخش داخل الاندوبلازمي + +367 +00:30:43,750 --> 00:30:48,690 +كريتكولام من خلال تاب البروتين اللي برتبط بلامة C + +368 +00:30:48,690 --> 00:30:53,230 +class I موليكيا الاندو سيتيك هو اكسوجين اس انتيجين + +369 +00:30:53,230 --> 00:30:57,410 +بسله اندو سايتوسيز او فايجو سايتوسيز وهو طبعا بيخش + +370 +00:30:57,410 --> 00:31:01,830 +على الاندو سيتيك compartment وهو بتحول الابيبتايد + +371 +00:31:02,420 --> 00:31:07,320 +هذه الـ peptide طبعا تطلع مرتبطة بال MSC class II + +372 +00:31:07,320 --> 00:31:13,420 +molecule طبعا ال باج الشجف هي عبارة عن protein + +373 +00:31:13,420 --> 00:31:17,520 +تتحلل ال amino acids اللي بيروح على اللي هو ال + +374 +00:31:17,520 --> 00:31:25,550 +amino acid الخوريهذا هو البروتيوزيوم البروتيوتليتك + +375 +00:31:25,550 --> 00:31:36,590 +الانزايم البروتيوتليتك + +376 +00:31:36,590 --> 00:31:36,730 +البروتيوتليتك البروتيوتليتك البروتيوتليتك + +377 +00:31:36,730 --> 00:31:36,730 +البروتيوتليتك البروتيوتليتك البروتيوتليتك + +378 +00:31:36,730 --> 00:31:36,730 +البروتيوتليتك البروتيوتليتك البروتيوتليتك + +379 +00:31:36,730 --> 00:31:38,650 +البروتيوتليتك البروتيوتليتك البروتيوتليتك + +380 +00:31:38,650 --> 00:31:39,050 +البروتيوتليتك البروتيوتليتك البروتيوتليتك + +381 +00:31:39,050 --> 00:31:40,530 +البروتيوتليتك البروتيوتليتك البروتيوتليتك + +382 +00:31:40,530 --> 00:31:40,530 +البروتيوتليتك البروتيوتليتك البروتيوتليتك + +383 +00:31:40,530 --> 00:31:45,770 +البروتيوتليتك البروتيوتليتك + +384 +00:31:45,770 --> 00:31:52,370 +البروتيوتليتكو هذه عبارة عن ال process بنوع من + +385 +00:31:52,370 --> 00:31:57,070 +التفصيل مش راح أطلبكوا فيها وهذه عبارة عن صورة ده + +386 +00:31:57,070 --> 00:32:00,870 +هي صار في عندها necrotizing granulomatous lesion + +387 +00:32:00,870 --> 00:32:06,250 +في منطقة الأنف due to TAB deficiency syndrome + +388 +00:32:06,250 --> 00:32:13,350 +وبهيك ان شاء الله بنكون أنهينا المحاضرة نتمنى أن + +389 +00:32:13,350 --> 00:32:16,730 +تكونوا قد استفدتم منها + diff --git a/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/GXz05Blmg9E_raw.srt b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/GXz05Blmg9E_raw.srt new file mode 100644 index 0000000000000000000000000000000000000000..f5edf9a722ad5246139861e5a7b8b7b39013f43d --- /dev/null +++ b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/GXz05Blmg9E_raw.srt @@ -0,0 +1,1824 @@ +1 +00:00:01,160 --> 00:00:04,920 +بسم الله الرحمن الرحيم الموضوع التاني في ال + +2 +00:00:04,920 --> 00:00:10,800 +immunopathology هو ال autoimmunity و ال + +3 +00:00:10,800 --> 00:00:14,980 +autoimmunity هو عبارة عن immune response against + +4 +00:00:14,980 --> 00:00:21,100 +self-antigen و حصلته حالة مرضية و غالبا بيحدث + +5 +00:00:21,100 --> 00:00:25,860 +نتيجة breakdown of self-tolerance او immune + +6 +00:00:25,860 --> 00:00:30,740 +tolerance ال immune tolerance of self-antigenهو + +7 +00:00:30,740 --> 00:00:35,280 +عبارة عن الهو مارك الأساسي for adaptive immune + +8 +00:00:35,280 --> 00:00:39,120 +response وعلمنا في محاضرة ال tolerance ال diesel + +9 +00:00:39,120 --> 00:00:41,860 +tolerance versus diesel tolerance وكيف بتتم + +10 +00:00:41,860 --> 00:00:48,180 +العملية ال diesel tolerance هي عبارة عن حالة بتتم + +11 +00:00:48,180 --> 00:00:53,190 +فيها إيش منهاالـ Autoreactive B lymphocyte لو طلعت + +12 +00:00:53,190 --> 00:00:58,610 +برا in peripheral ووصلت لمف نود على سبيل المثال + +13 +00:00:58,610 --> 00:01:03,490 +المانحة من دخول اللي هو T cell follicle area او + +14 +00:01:03,490 --> 00:01:07,110 +Inter primary follicles في ال primary follicle في + +15 +00:01:07,110 --> 00:01:11,150 +ال T lymphocyte وبالتالي بنمنحها من مساعدة ال T + +16 +00:01:11,150 --> 00:01:16,200 +lymphocyte في التنشيطيبقى وكأننا بنبعد ما بين ال T + +17 +00:01:16,200 --> 00:01:19,920 +cell و ال B cell و طبعا ال B cell اوتو رياكت ال B + +18 +00:01:19,920 --> 00:01:23,200 +cell without the help of T cell will not induce + +19 +00:01:23,200 --> 00:01:28,340 +will not be activated maintenance of T cell + +20 +00:01:28,340 --> 00:01:31,620 +tolerance تقول ان فيه اكتر من ميكانيزم منها + +21 +00:01:31,620 --> 00:01:35,600 +الclonal deletion اللي بيصير في الثيمس و منها ال + +22 +00:01:35,600 --> 00:01:39,600 +sequestration of antigenأن الانتجين يكون إما + +23 +00:01:39,600 --> 00:01:43,880 +inside the nucleus أو غير مرئي للـ it's not seen + +24 +00:01:43,880 --> 00:01:49,740 +يعني it's not accessible للخلايا المنعية زي وجوده + +25 +00:01:49,740 --> 00:01:53,580 +في ال brain أو ال eye أو ال testis أو انه logical + +26 +00:01:53,580 --> 00:01:56,300 +tolerance لما يكون فيه low affinity أو low + +27 +00:01:56,300 --> 00:02:00,960 +concentration to the antigen or T cell do not + +28 +00:02:00,960 --> 00:02:04,900 +cross the barrier في حالات ال energy يوم يكون في + +29 +00:02:04,900 --> 00:02:08,420 +lack of co stimulation أو superوالـ Suppression + +30 +00:02:08,420 --> 00:02:13,680 +لهو الـ TS Cell اللي بتعمل Suppression لها و + +31 +00:02:13,680 --> 00:02:19,860 +Regulation لكل الخلايا المناعية الفاعلة Inducing + +32 +00:02:19,860 --> 00:02:22,780 +autoimmunity or breakdown Breaking of self + +33 +00:02:22,780 --> 00:02:27,120 +-tolerance بيحدث نتيجة أسباب متعددة منها ال energy + +34 +00:02:27,120 --> 00:02:31,700 +or infection ومصطلح ال viral trigger هو برا + +35 +00:02:31,700 --> 00:02:35,240 +المصطلح يطلق على ال viral infection اللي بيقدّي + +36 +00:02:35,240 --> 00:02:41,030 +إلىالـ autoimmune disease و هذه أسباب مختلفة لل + +37 +00:02:41,030 --> 00:02:48,330 +autoimmune disease منها disruption of cell or + +38 +00:02:48,330 --> 00:02:54,350 +tissue barrier خلايا بتتعرض إلى تهدك بتطلع منها + +39 +00:02:54,350 --> 00:03:00,320 +sequestered antigenبتتعرف عليه الخلايا الـ Antigen + +40 +00:03:00,320 --> 00:03:06,180 +Presenting Cell و بتقدمولها اللي هو T-Lymphocyte و + +41 +00:03:06,180 --> 00:03:11,280 +بتبدأ تتنشط هذه الخلايا فطبعا immune response + +42 +00:03:11,280 --> 00:03:15,700 +أمثلة كثيرة على Sequestered أمثلة من Sequestered + +43 +00:03:15,700 --> 00:03:20,480 +Antigen منها sympathetic أوبثالميا اللي هو التهدك + +44 +00:03:20,480 --> 00:03:27,880 +في الشبكية أو في العينبشكل عام او سيكوسترونت انتجن + +45 +00:03:27,880 --> 00:03:32,240 +اللي بينتج نتيجة من ال heart after is chemical + +46 +00:03:32,240 --> 00:03:36,640 +attack النوع التاني infection of antigen + +47 +00:03:36,640 --> 00:03:39,520 +-presenting cell انه بعد مرة during inflammation + +48 +00:03:39,520 --> 00:03:44,540 +بيصير فيه او يعني inappropriate expression لماسيكا + +49 +00:03:44,540 --> 00:03:48,860 +مليكيول وبالتالي بيصير فيه more presentation + +50 +00:03:48,860 --> 00:03:55,320 +للانتجن يعني moreاللي هو attack وطبعا الشغل كتير + +51 +00:03:55,320 --> 00:03:58,620 +بيؤدي إلى خلل في ال immune response وهذا بيؤدي إلى + +52 +00:03:58,620 --> 00:04:03,540 +اللي هو ال auto immunity.Binding of pathogen to + +53 +00:04:03,540 --> 00:04:11,700 +self protein مرات بيكون فيه ارتباط لل pathogen + +54 +00:04:11,700 --> 00:04:21,020 +وبيعتبر as a carrier for self proteinطبعا كتير + +55 +00:04:21,020 --> 00:04:27,000 +الحدث المشهور في الأسئلة E يوم يكون فيه kidney + +56 +00:04:27,000 --> 00:04:33,180 +involvement بيصير فيه nephritis و بيصير فيه tissue + +57 +00:04:33,180 --> 00:04:39,640 +damage و بيصير فيه ارتباط ب self-antigen او طبعا + +58 +00:04:39,640 --> 00:04:42,160 +self-protein في هذه الحالة يقدم لتيه البرسيلو + +59 +00:04:42,160 --> 00:04:48,990 +بيصير فيه ايش auto immunityموليكيلار موميكري يوم + +60 +00:04:48,990 --> 00:04:52,250 +يتشابه الـ Foreign Antigen بالـ Self Antigen بيصير + +61 +00:04:52,250 --> 00:04:56,390 +فيه Auto .. يعني بيصير فيه Immune Response وطبعاً + +62 +00:04:56,390 --> 00:05:01,290 +for both Self and Foreign Antigen وبالتالي بيصير + +63 +00:05:01,290 --> 00:05:04,890 +فيه Autoimmune Disease Super Antigen يوم بيصير فيه + +64 +00:05:04,890 --> 00:05:07,250 +Polyclonal Activation لعدد كبير من الـ T + +65 +00:05:07,250 --> 00:05:11,390 +lymphocytes بما فيها الـ Autoreactive T Cell بيؤدي + +66 +00:05:11,390 --> 00:05:17,570 +إلى اللي هو Autoimmune Disease وطبعا مثال حيعلى + +67 +00:05:17,570 --> 00:05:23,170 +ذلك هو الـ Rheumatoid Arthritis الـ breakdown of + +68 +00:05:23,170 --> 00:05:28,790 +self-tolerance طبعا بيحصل زي ما شفنا في المثال + +69 +00:05:28,790 --> 00:05:32,030 +السابق أنه في release of sequestered antigen بيحصل + +70 +00:05:32,030 --> 00:05:36,350 +في tissue damage by infection و بيأدى هذا إلى أن + +71 +00:05:36,350 --> 00:05:39,210 +ال T lymphocyte و ال B lymphocyte بي sequestered + +72 +00:05:39,210 --> 00:05:44,750 +لذات antigen و بتقدم ل .. و بتنشط التنتينالنوع + +73 +00:05:44,750 --> 00:05:47,110 +التالي اللي هو الـ Antigenic or Molecular Mimicry + +74 +00:05:47,110 --> 00:05:50,050 +هو ما يتشابه زي ما قلنا similarity between foreign + +75 +00:05:50,050 --> 00:05:54,550 +and self-protein بيؤدي إلى cross-reactivity وهنا + +76 +00:05:54,550 --> 00:06:01,290 +أمثلة كبيرة كثيرة جدا عن ال molecular mimicry ال + +77 +00:06:01,290 --> 00:06:05,290 +inappropriate expression of MHC class II موليكول + +78 +00:06:05,290 --> 00:06:10,290 +هذا بيصير في اللي هو حالة ال inflammationإنه بيصير + +79 +00:06:10,290 --> 00:06:12,970 +فيه inappropriate expression بيؤدي إلى + +80 +00:06:12,970 --> 00:06:20,250 +presentation of self-antigen وبالتالي self-antigen + +81 +00:06:20,250 --> 00:06:23,810 +الـ T-lymphocyte ما شافته during thymus life + +82 +00:06:23,810 --> 00:06:29,690 +وبالتالي بيؤدي إلى ال activation of T cellالخاصية + +83 +00:06:29,690 --> 00:06:33,690 +الـ autoimmune disease قسمها إلى تلت أنواع أساسية + +84 +00:06:33,690 --> 00:06:37,230 +نحن نحكي في نوعين أساسيين الأولان يوم يكون الـ + +85 +00:06:37,230 --> 00:06:40,370 +antibody هو المشكلة الأساسية يعني يتكون auto + +86 +00:06:40,370 --> 00:06:44,790 +antibody والنوع التاني يوم التيسل تتنشط ويصير فيه + +87 +00:06:44,790 --> 00:06:48,070 +يعني تنشيط لخلايا أخرى ويصير فيه tissue damage + +88 +00:06:48,070 --> 00:06:50,830 +والنوع التالت اللي هو ال complement deficiency + +89 +00:06:50,830 --> 00:06:54,010 +وبرضه بيؤدي إلى ال autoimmune disease خلّين ناخد + +90 +00:06:54,010 --> 00:06:58,130 +أمثلة على ذلكطبعاً هذا مثال حقيقي جداً Autoimmune + +91 +00:06:58,130 --> 00:07:01,970 +Hemorrhagic Anemia يوم يتكوّن Antibody to RBCs + +92 +00:07:01,970 --> 00:07:06,830 +يحدث في قتل إما بـ Intracellular أو إما بـ + +93 +00:07:06,830 --> 00:07:11,730 +Extracellular طبعاً في ال Intracellular أو ال + +94 +00:07:11,730 --> 00:07:16,260 +Extracellularبصير تنشيط للـ complement بالمناسبة + +95 +00:07:16,260 --> 00:07:19,640 +بقى في ال extracellular complete activation بصير و + +96 +00:07:19,640 --> 00:07:22,260 +بصير في ال direct license في ال extracellular + +97 +00:07:22,260 --> 00:07:25,860 +بتصير في optionization هي و ال antibody و برضه + +98 +00:07:25,860 --> 00:07:31,890 +بصير في license لل RBCsAuto-antibody to surface + +99 +00:07:31,890 --> 00:07:35,530 +receptor وفي منه أنواع مختلفة يعني كثيرة منها + +100 +00:07:35,530 --> 00:07:40,250 +Stimulatory auto-antibody يوم يشتغل الانتبادي ك + +101 +00:07:40,250 --> 00:07:46,790 +agonist بيرتبط ب TSH ريسبتور وبالتالي بيشتغل ك اذا + +102 +00:07:46,790 --> 00:07:49,890 +قولنا agonist يعني بيعمل stimulation لthyroid + +103 +00:07:49,890 --> 00:07:52,710 +gland وبالتالي يحصل فيه stimulation ل hormone + +104 +00:07:52,710 --> 00:07:56,370 +synthesis وبالتالي يصبح المحصلة hyperthyroidism + +105 +00:07:58,400 --> 00:08:02,880 +النوع التاني من الـ antibody اللي هوPlucking + +106 +00:08:02,880 --> 00:08:05,960 +Antibody او Inhibitory Antibody هنشوف برضه + +107 +00:08:05,960 --> 00:08:10,140 +Inhibition By Other Types او Other Diseases لإن + +108 +00:08:10,140 --> 00:08:12,740 +Plucking Antibody هذا Antibody Against + +109 +00:08:12,740 --> 00:08:16,640 +Acetylcholine Receptor فبيجي ال Antibody وبيعمل + +110 +00:08:16,640 --> 00:08:21,020 +ارتباط بال Acetylcholine Receptor طبعا كلنا بنعرف + +111 +00:08:21,020 --> 00:08:23,440 +ال Acetylcholine Receptor هو برنامج Chemical + +112 +00:08:23,440 --> 00:08:28,140 +Messenger بيعمل بينقل إشارة عصبية للعضلات وبالتالي + +113 +00:08:29,270 --> 00:08:33,230 +مسينجر نيرو ماسكولار مسينجر وبالتالي بيصير فيه + +114 +00:08:33,230 --> 00:08:38,110 +عملية حركة فطبعا إذا كان مشتغلش العضلة مشتغلت + +115 +00:08:38,110 --> 00:08:42,830 +تتحرك المحاصلة paralysis المحاصلة paralysis فاللي + +116 +00:08:42,830 --> 00:08:48,410 +بيصير انه ال acetylcholine ال receptor بتكون ال + +117 +00:08:48,410 --> 00:08:50,990 +auto antibody بيجي ال antibody وبيمسك فيه فبيعمل + +118 +00:08:50,990 --> 00:08:53,210 +blocking بيجي ال acetylcholine بيلاقي ال antibody + +119 +00:08:53,210 --> 00:08:58,300 +ال receptor تبعه مجغول فبالتالي ما بيشتغلهاشي + +120 +00:08:58,300 --> 00:09:03,320 +موتورز تيرو دايتست برضه انتيبادي لكن هذا انهيبتوري + +121 +00:09:03,320 --> 00:09:09,580 +انتيبادي بعمل blocking ل ال thyroid function من + +122 +00:09:09,580 --> 00:09:14,900 +خلال ايش من خلال ال inhibition for thyroglobulin + +123 +00:09:14,900 --> 00:09:20,720 +ماشي and thyroid cells وبالتالي المحصلة انه بتبطل + +124 +00:09:20,720 --> 00:09:26,740 +تشتغلفبالتالي مافيش ايش release + +125 +00:09:26,740 --> 00:09:31,180 +او secretion للثيرويدر هورمون محاصلة + +126 +00:09:31,180 --> 00:09:34,600 +hypothyroidism good bastard syndrome أوت و + +127 +00:09:34,600 --> 00:09:39,300 +antibody ضد ال collagen number four و non + +128 +00:09:39,300 --> 00:09:43,040 +collagenous basement membrane برتبط طبعا في الكدنى + +129 +00:09:43,040 --> 00:09:48,120 +و ال lung هذا ال collagen موجود برتبط causing + +130 +00:09:48,120 --> 00:09:51,500 +inflammation and destruction of these organs + +131 +00:09:52,510 --> 00:09:57,110 +Rheumatoid Arthritis O2 Antibody To Upiquitous + +132 +00:09:57,110 --> 00:10:04,250 +Antigen IGM ضد IGA بيسموه Rheumatoid Factor IGG ضد + +133 +00:10:04,250 --> 00:10:10,790 +G6PD أيضا هو برعن Upiquitous Antigen Primary + +134 +00:10:10,790 --> 00:10:13,970 +Disease Manifestation طبعا مثل آخر هذا Primary + +135 +00:10:13,970 --> 00:10:16,770 +Disease Manifestation محصلة لأميون Complexes بسلة + +136 +00:10:16,770 --> 00:10:21,670 +Deposition في ال joints و بيصير Inflammatory + +137 +00:10:22,450 --> 00:10:26,910 +Trigger Inflammatory Response المحصلة كومبليمنت و + +138 +00:10:26,910 --> 00:10:33,470 +FC-Gamma Receptor IGG تلعب رولة كبيرة IGG تلعب + +139 +00:10:33,470 --> 00:10:34,250 +رولة كبيرة IGG تلعب رولة IGG تلعب رولة IGG تلعب + +140 +00:10:34,250 --> 00:10:35,850 +رولة IGG تلعب رولة IGG تلعب رولة IGG تلعب رولة IGG + +141 +00:10:35,850 --> 00:10:37,350 +تلعب رولة IGG تلعب رولة IGG تلعب رولة IGG تلعب + +142 +00:10:37,350 --> 00:10:39,510 +رولة IGG تلعب رولة IGG تلعب رولة IGG تلعب رولة IGG + +143 +00:10:39,510 --> 00:10:40,770 +تلعب رولة IGG تلعب رولة IGG تلعب رولة IGG تلعب + +144 +00:10:40,770 --> 00:10:50,050 +رولة IGG تلعب رولة IGG تلعب رولة IGG + +145 +00:10:50,700 --> 00:10:54,820 +أدت أعضاء الجسم واحد ورا التاني بيصيب مهاجمة لهم + +146 +00:10:54,820 --> 00:10:58,580 +وبالتالي المحاصلة infarction for this organ + +147 +00:10:58,580 --> 00:11:03,220 +والمحاصلة في النهاية death في ال Systemic + +148 +00:11:03,220 --> 00:11:07,500 +Leukocytic Rheumatosis أيضًا أيضًا بيتكون Antibody + +149 +00:11:07,500 --> 00:11:10,920 +for نيكليوبروتين Particles زي نيكليوزوم سبايسوزوم + +150 +00:11:10,920 --> 00:11:15,160 +رابن نيكليوبروتين Complexes وطبعًا في هذه الحالة + +151 +00:11:15,160 --> 00:11:18,440 +تهيب ال response to one Epitope Candidate O2 + +152 +00:11:18,440 --> 00:11:23,830 +Antibodyهذا مثال حقيقي جدا على هذا الموضوع انه + +153 +00:11:23,830 --> 00:11:30,410 +بتبدأ اللي هو ال T البرسيل الابيتوب بي can provide + +154 +00:11:30,410 --> 00:11:34,970 +multiple antibody epitopes in the same particles + +155 +00:11:34,970 --> 00:11:40,910 +هي بتكون للنكليزوم ال single و ال double strand + +156 +00:11:40,910 --> 00:11:47,950 +DNA و هكذا ال DNA أنا بصير في عملية ايش اللي هو + +157 +00:11:47,950 --> 00:11:53,190 +الارتباطوهن ال activation لل بي سل وبالتالي بيصير + +158 +00:11:53,190 --> 00:11:58,490 +فيه secretion ل أوتو انتبادي potential cycle for + +159 +00:11:58,490 --> 00:12:03,250 +اسئل ايه الimmune complexes بتؤدي لمحصلتها + +160 +00:12:03,250 --> 00:12:06,790 +deposition in the joints small blood vessels بيصير + +161 +00:12:06,790 --> 00:12:09,070 +فيه condiment activation بيصير فيه activation of + +162 +00:12:09,070 --> 00:12:12,250 +phagocytes احنا في phagocytosis و tissue damage + +163 +00:12:12,250 --> 00:12:17,050 +damage make causes more release of intracellular + +164 +00:12:17,050 --> 00:12:19,570 +antigen والمحصلة immune complexes + +165 +00:12:22,340 --> 00:12:27,720 +مرض آخر تلينفوسات بتلعب دور كبير فيه هو multiple + +166 +00:12:27,720 --> 00:12:32,120 +sclerosis بيصير فيه damage to the myelin باسيك + +167 +00:12:32,120 --> 00:12:38,710 +بروتينو من خلال هذا بيصير فيه الـ Myelin Sheet + +168 +00:12:38,710 --> 00:12:41,950 +بيصير لها Destruction و كنا عارفين ان الـ Myelin + +169 +00:12:41,950 --> 00:12:47,430 +Sheet هي القنوات التي توصل لإشارات العصبية فبيصير + +170 +00:12:47,430 --> 00:12:51,130 +فيه neurological symptoms السبب لغاية الآن مش + +171 +00:12:51,130 --> 00:12:56,110 +معروف لكن بيقولون انه during inflammatory response + +172 +00:12:56,110 --> 00:13:04,010 +a viral infection ممكن يكون موجود ملت ميليانين + +173 +00:13:06,190 --> 00:13:11,230 +ميزل بروتين مع ميزل + +174 +00:13:11,230 --> 00:13:13,150 +بروتين مع ميزل بروتين مع ميزل بروتين مع ميزل + +175 +00:13:13,150 --> 00:13:13,730 +بروتين مع ميزل بروتين مع ميزل بروتين مع ميزل + +176 +00:13:13,730 --> 00:13:13,790 +بروتين مع ميزل بروتين مع ميزل بروتين مع ميزل + +177 +00:13:13,790 --> 00:13:14,710 +بروتين مع ميزل بروتين مع ميزل بروتين مع ميزل + +178 +00:13:14,710 --> 00:13:15,150 +بروتين مع ميزل بروتين مع ميزل بروتين مع ميزل + +179 +00:13:15,150 --> 00:13:18,370 +بروتين مع ميزل بروتين مع ميزل بروتين مع ميزل + +180 +00:13:18,370 --> 00:13:23,850 +بروتين مع ميزل بروتين مع ميزل بروتين مع ميزل + +181 +00:13:23,850 --> 00:13:32,510 +بروتين مع ميزل بروتين مع ميزل بروتين + +182 +00:13:33,590 --> 00:13:38,210 +في عيلة لانجرهانز أو بانكرياز و احنا عارفين ان ال + +183 +00:13:38,210 --> 00:13:40,430 +beta cell هي اللي بتفرز الانسفرين فببطل فيه + +184 +00:13:40,430 --> 00:13:44,030 +انسفرين و بيصير فيه diabetes mellitus + +185 +00:13:49,120 --> 00:13:53,240 +الـ Lagerhans cells اللي هي Alpha و Beta و Delta + +186 +00:13:53,240 --> 00:13:58,940 +Alpha بتعطينا اللي هو Glucagon و Beta الانسولين و + +187 +00:13:58,940 --> 00:14:04,340 +Delta سوماتوس تعطينا طبعا المهاجمة بتصير للانسولين + +188 +00:14:04,340 --> 00:14:09,480 +اللي هي ال beta ال islet of beta cell وبالتالي + +189 +00:14:09,480 --> 00:14:16,100 +هجمتها ال cytotoxic بطل في beta يعني بطل في + +190 +00:14:16,100 --> 00:14:24,380 +انسولينطبعا بيقولوا انه ال .. برضه الناس هذول + +191 +00:14:24,380 --> 00:14:27,580 +عندهم auto antibody لكن ال .. وجدوا ان ال auto + +192 +00:14:27,580 --> 00:14:33,600 +antibody alone cannot cause diabetes relative risk + +193 +00:14:33,600 --> 00:14:39,100 +يعني ال ratio of having a specific MSC قليل بتزيد + +194 +00:14:39,100 --> 00:14:45,240 +increase risk for that disease يعني على سبيل + +195 +00:14:45,240 --> 00:14:52,020 +المثال HLA-B27 اذا وجدعند الناس القليل طبعا of MHC + +196 +00:14:52,020 --> 00:14:57,860 +ماشي بتصير نسبة الإصابة الانكالوزين سبندلاليتس 87% + +197 +00:14:57,860 --> 00:15:02,700 +او 87 ضعف اكتر من ايش من ال normal or healthy او + +198 +00:15:02,700 --> 00:15:07,400 +الناد اللي ما عندهم مش هذا القليل يعني ال relative + +199 +00:15:07,400 --> 00:15:10,900 +risk بتكون عالية جدا عندهمالناس اللي عندهم + +200 +00:15:10,900 --> 00:15:15,500 +diabetes mellitus وجدوا انه عندهم HLADR تلاتة DR + +201 +00:15:15,500 --> 00:15:22,060 +أربعة ووجدوا انه وجوده بيزود الإصابة increase risk + +202 +00:15:22,060 --> 00:15:26,460 +relative risk بخمس وعشرين ضعيف عن ال normal + +203 +00:15:26,460 --> 00:15:32,220 +susceptibility factor according to gender وجدوا + +204 +00:15:32,220 --> 00:15:36,800 +انه increase risk associated with gender فعلى سبيل + +205 +00:15:36,800 --> 00:15:43,660 +المثال female to male ratioفي الاسقل E10 ل 1 في ال + +206 +00:15:43,660 --> 00:15:48,620 +multiple sclerosis 5 ل 1 في ال Hashimoto's + +207 +00:15:48,620 --> 00:15:53,580 +thyroiditis 4 ل 1 لكن في ال diabetes mellitus 1 ل + +208 +00:15:53,580 --> 00:15:58,920 +1 وفي الunglosing spondylitis point 3 الفيميل + +209 +00:15:58,920 --> 00:15:59,840 +والمايل + +210 +00:16:04,810 --> 00:16:08,430 +سبتريريتي في أكتر ميون ريجوليشن جين اكتر من ميون + +211 +00:16:08,430 --> 00:16:10,790 +ريجوليشن جين اكتر من ميون ريجوليشن جين اكتر من + +212 +00:16:10,790 --> 00:16:12,570 +ميون ريجوليشن جين اكتر من ميون ريجوليشن جين اكتر + +213 +00:16:12,570 --> 00:16:16,650 +من ميون ريجوليشن جين اكتر من ميون ريجوليشن جين + +214 +00:16:16,650 --> 00:16:19,470 +اكتر من ميون ريجوليشن جين اكتر من ميون ريجوليشن + +215 +00:16:19,470 --> 00:16:25,230 +جين اكتر من ميون ريجوليشن جين اكتر من ميون + +216 +00:16:25,230 --> 00:16:30,430 +ريجوليشن جين اكتر من ميون ريجوليشن جين اكتر من + +217 +00:16:30,430 --> 00:16:33,550 +ميون ريجولي + +218 +00:16:36,450 --> 00:16:43,890 +with SLE و + +219 +00:16:43,890 --> 00:16:48,650 +decrease expression decrease amount of complement + +220 +00:16:48,650 --> 00:16:59,510 +بروتين C3 C1 C2 C4 بيدي + +221 +00:16:59,510 --> 00:17:05,150 +الى اللي هو أيضا ال SLE + +222 +00:17:12,850 --> 00:17:20,270 +النسبة للإنفاق البيئي على سبيل المثال تم + +223 +00:17:20,270 --> 00:17:25,270 +تشكيله بـ Godbusters Syndrome بمعنى الـ potential + +224 +00:17:25,270 --> 00:17:29,190 +damage of tissue of the otolung basement membrane + +225 +00:17:29,190 --> 00:17:31,430 +يساعد في إشعال مرض اتفاق اتفاق اتفاق اتفاق اتفاق + +226 +00:17:31,430 --> 00:17:39,670 +اتفاق اتفاق اتفاق اتفاق اتفاق اتفاق + +227 +00:17:41,010 --> 00:17:47,130 +Exposure and عوامل كثيرة جدا قد تؤدي إلى إيش؟ ك + +228 +00:17:47,130 --> 00:17:53,510 +Triggering factor لل autoimmune disease Treatment + +229 +00:17:53,510 --> 00:18:00,330 +قالوا علاجوها فارماكو ثيرابي عطوا Anti + +230 +00:18:00,330 --> 00:18:03,450 +-inflammatories زي استيرويد ونانستيرويد Anti + +231 +00:18:03,450 --> 00:18:07,880 +-inflammatory drugsوبعض العلاجات كانت specific زي + +232 +00:18:07,880 --> 00:18:13,720 +الانسولين في diabetes mellitus وبعض ال + +233 +00:18:13,720 --> 00:18:17,560 +immunotherapy بدوا يستخدموها زي blocking of co + +234 +00:18:17,560 --> 00:18:24,440 +-stimulatory reaction او موليكيول زي ال B7 وCD28 + +235 +00:18:24,440 --> 00:18:28,120 +او بيبتايد وعطوفاكسين + +236 +00:18:30,170 --> 00:18:34,230 +مشي عملت plug-in لل-MHC مليكيول ومنعت ال + +237 +00:18:34,230 --> 00:18:38,670 +activation of T lymphocytes وبالتالي منعت ال + +238 +00:18:38,670 --> 00:18:42,230 +binding of antigen ومافيش presentation يبقى ومافيش + +239 +00:18:42,230 --> 00:18:48,230 +activation ال tolerance ايضا استخدم زي ال myelin + +240 +00:18:48,230 --> 00:18:52,390 +basic protein اعطوه بكميات كبيرة to induce + +241 +00:18:52,390 --> 00:18:59,450 +tolerance for patient يمكن ان نكون خلصنا جزء تاني + +242 +00:18:59,450 --> 00:19:08,400 +منالمخادرة واللي أرجو أن تكونوا قد استفدتم منه + +243 +00:19:08,400 --> 00:19:16,960 +شكرا جزء التالت معنى بال immunodeficiency و ال + +244 +00:19:16,960 --> 00:19:25,760 +immunodeficiency هي عبارة عن ميكانيزمات منعية + +245 +00:19:25,760 --> 00:19:31,190 +ناقصةزي على سبيل المثال خلال في الـ skin و الـ + +246 +00:19:31,190 --> 00:19:36,190 +mucosal barrier بيسمح بدخول antigen بيبرى ال + +247 +00:19:36,190 --> 00:19:42,350 +immunity V cell بلازمة cell antibody أيضًا غيابهم + +248 +00:19:42,350 --> 00:19:48,490 +بيؤدي إلى اللي هو ال immunodeficiency state cell + +249 +00:19:48,490 --> 00:19:51,250 +mediated immunity Z cell phagocytosis and + +250 +00:19:51,250 --> 00:19:55,580 +complement هذه أدواتأتيها الـ immune response خلال + +251 +00:19:55,580 --> 00:19:59,180 +فيها بيؤدي إلى خلال ال immunodeficiency status + +252 +00:19:59,180 --> 00:20:03,300 +Suspected immunodeficiency بداك تدور على إنسان صار + +253 +00:20:03,300 --> 00:20:11,440 +عنده Infection على شكل frequent و recurrent و ممكن + +254 +00:20:11,440 --> 00:20:15,900 +يكون chronic ثم Unusual organism بعد ميكروبات + +255 +00:20:15,900 --> 00:20:20,380 +حاملة أو تافهة بتؤدي إلى infection فظيعة ثم + +256 +00:20:20,380 --> 00:20:24,540 +organism that respond poorly to therapyبعد ال + +257 +00:20:24,540 --> 00:20:29,520 +organism which are resistant to therapy ثم growth + +258 +00:20:29,520 --> 00:20:34,080 +retardation عند ال patient and family history كل + +259 +00:20:34,080 --> 00:20:39,280 +هذه عوامل بدها تلفت نظرك لإن هناك immunodeficiency + +260 +00:20:39,280 --> 00:20:45,820 +طيب ال immunodeficiency نشوف + +261 +00:20:45,820 --> 00:20:48,660 +يوم ما يكون هناك humoral or antibody deficiency + +262 +00:20:48,660 --> 00:20:53,170 +اللي هو associated with recurrent infectionWith + +263 +00:20:53,170 --> 00:20:57,610 +Encapsulated BacteriaChronic Sinopalmonary + +264 +00:20:57,610 --> 00:21:00,910 +Infectionبينما + +265 +00:21:00,910 --> 00:21:03,430 +الـ Cell Mediated deficiency اللي هو Characterized + +266 +00:21:03,430 --> 00:21:07,330 +By Current Infection With Viruses فنجعي و + +267 +00:21:07,330 --> 00:21:12,290 +Fortunately Organism و المحاصلة ديارية و Wasting و + +268 +00:21:12,290 --> 00:21:16,650 +Gross Retardation وفيه Combined Humeral and ash + +269 +00:21:16,650 --> 00:21:22,090 +and Cell Mediated وطبعا هي التقسيمة الأساسيةهي الـ + +270 +00:21:22,090 --> 00:21:27,370 +bone marrow اللي فت الليمفه طبعا ال stem cell أدت + +271 +00:21:27,370 --> 00:21:30,610 +إلى ال limfoid precursor اللي أدتنا ال T + +272 +00:21:30,610 --> 00:21:33,390 +lymphocyte و ال B lymphocyte طبعا انتوا عارفين + +273 +00:21:33,390 --> 00:21:37,230 +محصلة T lymphocyte انها بتبدي cell mediated وهذا + +274 +00:21:37,230 --> 00:21:40,930 +بتبدي immunal immunity وفي collaboration between + +275 +00:21:40,930 --> 00:21:45,150 +them محصلة release of cytokine ده هو activation of + +276 +00:21:45,150 --> 00:21:47,850 +cell هذي بتبدينا antibody وهذا بتبدينا cell + +277 +00:21:47,850 --> 00:21:54,280 +mediated immunityطبعا احنا بنحكي على اللي هو الخلل + +278 +00:21:54,280 --> 00:22:00,100 +في هذه الأدوة ونبدأ بالـ humoral part or humoral + +279 +00:22:00,100 --> 00:22:04,240 +immunodeficiency خلل فيهاش في الـB الأمراض + +280 +00:22:04,240 --> 00:22:10,790 +المتعلقة بالـBزي Transient Hypopneumoglobulinemia + +281 +00:22:10,790 --> 00:22:15,850 +Transient of infancy انه بيصير فيه slow to develop + +282 +00:22:15,850 --> 00:22:20,950 +normal level of antibody ببطء شديد في الغالب + +283 +00:22:20,950 --> 00:22:25,830 +asymptomatic لكن بيصير فيه infection even with + +284 +00:22:25,830 --> 00:22:31,110 +minor infection ثم + +285 +00:22:31,110 --> 00:22:36,970 +لو فحصنا المريض حتى اللي عنده low level of IgAوال + +286 +00:22:36,970 --> 00:22:47,450 +IGM غالبا normal المرض عبارة عن self يعني + +287 +00:22:47,450 --> 00:22:52,030 +self + +288 +00:22:52,030 --> 00:23:02,230 +dependent resolve within three to six years IGA + +289 +00:23:02,230 --> 00:23:06,880 +deficiency ده ال most commonخمسية ل تمانية في + +290 +00:23:06,880 --> 00:23:09,880 +المية بتكون asymptomatic لكن بيصير فيه recurrent + +291 +00:23:09,880 --> 00:23:14,000 +sinopalmonary infection و it has severe + +292 +00:23:14,000 --> 00:23:17,400 +malabsorption وبالتالي بيصيرت chronic ذيارية + +293 +00:23:17,400 --> 00:23:24,500 +isolated low level low IgA level وفيه زيادة لل + +294 +00:23:24,500 --> 00:23:29,780 +autoimmune disease protons X-linked + +295 +00:23:29,780 --> 00:23:33,660 +regamoglobulinemia من اسم there is no B at all B + +296 +00:23:33,660 --> 00:23:38,260 +cell at allطبعا الأطفال هدولة في أول ست شهور من + +297 +00:23:38,260 --> 00:23:40,940 +العمر بيصير عندهم recurrent في العبر و ال lower + +298 +00:23:40,940 --> 00:23:44,500 +respiratory tract infection with encapsulated + +299 +00:23:44,500 --> 00:23:49,680 +bacteria, septococcus pneumonia, haemophilus + +300 +00:23:49,680 --> 00:23:56,380 +influenza طبعا بيصير المريض عنده proncoctiasis, + +301 +00:23:57,160 --> 00:24:01,320 +chronic cough بعد increase in sputum بيصير عنده + +302 +00:24:01,320 --> 00:24:05,590 +sepsis, meningitis, skin infectionبعض المسلحات + +303 +00:24:05,590 --> 00:24:11,190 +الليمونية والتنسل والأدينويد تكون قليلة ماركت + +304 +00:24:11,190 --> 00:24:14,770 +تقليل في ال IGG وال IGA وال IGM والتعامل + +305 +00:24:14,770 --> 00:24:18,470 +بالإمينoglobulin أو Intravenous immunoglobulin مع + +306 +00:24:18,470 --> 00:24:23,570 +تقليل الانتيبايتك ثيرابي عامة عامة عامة عامة عامة + +307 +00:24:23,570 --> 00:24:24,130 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +308 +00:24:24,130 --> 00:24:24,270 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +309 +00:24:24,270 --> 00:24:24,350 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +310 +00:24:24,350 --> 00:24:25,370 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +311 +00:24:25,370 --> 00:24:25,930 +عامة عامة + +312 +00:24:33,440 --> 00:24:38,160 +للتفرانشية في بلازمة سيل مافيش تفرانشية طبعا الـ + +313 +00:24:38,160 --> 00:24:40,780 +Current Sinopalmonary طبعا مافيش بلازمة سيل فيش + +314 +00:24:40,780 --> 00:24:45,380 +Antibody Recurrent Sinopalmonary Infection ولو + +315 +00:24:45,380 --> 00:24:50,340 +طلعنا على ال Antibody IgG IgA IgM is low and + +316 +00:24:50,340 --> 00:24:54,840 +treatment intravenous immunoglobulin وهذه غالبا + +317 +00:24:54,840 --> 00:24:58,560 +associated with autoimmune disease and lymphoma + +318 +00:25:00,290 --> 00:25:04,190 +اللغة التانية من ال immunodeficiency هو ال T cell + +319 +00:25:04,190 --> 00:25:10,470 +ديجورد + +320 +00:25:10,470 --> 00:25:20,010 +سندروم أشهر T cell impairment مافيش T cell في هذا + +321 +00:25:20,010 --> 00:25:23,690 +المرض secondary to thymic hyperplasia لأن الthymus + +322 +00:25:23,690 --> 00:25:28,290 +مش موجودطبعا catch-22 في هذه الحالة يعني إيه؟ + +323 +00:25:28,290 --> 00:25:32,410 +بتدور على حركة على طول بتدي alarm بتدي بتقولك إنه + +324 +00:25:32,410 --> 00:25:35,650 +في شيء خطر فشو بيصير؟ Overwhelming infection with + +325 +00:25:35,650 --> 00:25:39,750 +viruses, fungi, bacteria و treatment بيصير عنده + +326 +00:25:39,750 --> 00:25:42,710 +hypocalcemia فبيدك تصلحها بيصير عنده cardiac + +327 +00:25:42,710 --> 00:25:46,550 +defect symptomatically treatment and fetal thymus + +328 +00:25:46,550 --> 00:25:53,990 +transplant هو الحل الوحيد طب يمكن يكون فيه إذراعين + +329 +00:25:53,990 --> 00:25:59,600 +خربنينهذه هي الـ A هنا يعني الـ lymphoid breakage + +330 +00:25:59,600 --> 00:26:04,960 +على نفسها ما اتكونت شو بيصير فيها بيصير فيه مرض + +331 +00:26:04,960 --> 00:26:08,460 +بيسموه SCID severe combined immunodeficiency + +332 +00:26:08,460 --> 00:26:15,940 +status وفي هذه الحالة الخلل في الاستمثال هو + +333 +00:26:15,940 --> 00:26:21,420 +adenosine deaminase deficiency غالباً بيصير toxic + +334 +00:26:21,420 --> 00:26:25,790 +insult to T and B lymphocytesهو عبارة عن سبب آخر + +335 +00:26:25,790 --> 00:26:31,050 +manifestation seen in first three months of life + +336 +00:26:31,050 --> 00:26:34,570 +نفس اللي هي كذا بيصير recurrent and severe + +337 +00:26:34,570 --> 00:26:37,690 +bacterial viral fungal and protozoa infection + +338 +00:26:37,690 --> 00:26:42,130 +وfailure to thrive صعب جدا بيصير عنده diarrhea, + +339 +00:26:42,270 --> 00:26:47,150 +dermatitis, candidiasis ومعظم المرضى بيكون عندهم + +340 +00:26:47,150 --> 00:26:52,690 +اللي بيصير عندهم lymphopenia وعندهم قلة في IGG IGA + +341 +00:26:52,690 --> 00:27:00,240 +IGMوهي التشخيص من خلال بيتم من خلال فحص ال T cell + +342 +00:27:00,240 --> 00:27:04,200 +و ال B cell و ال NK cell subset treatment + +343 +00:27:04,200 --> 00:27:09,260 +isolation مريض من هالنوع طبعا بيكون ماعندوش مناع + +344 +00:27:09,260 --> 00:27:16,000 +عنهائي فبنعزل treat underlying infection and do + +345 +00:27:16,000 --> 00:27:20,860 +bone marrow transplantation Wescott Eldrich + +346 +00:27:20,860 --> 00:27:26,420 +Syndrome هو برنامج X-linked recessiveSyndrome + +347 +00:27:26,420 --> 00:27:31,340 +Symptoms in Infancy Recurrent Severe Infection and + +348 +00:27:31,340 --> 00:27:37,000 +Eczema Thrombocytopenia نحكي على Syndrome طبعا و + +349 +00:27:37,000 --> 00:27:41,300 +عنده low level YGM و زيادة في الميتولوجيا + +350 +00:27:41,300 --> 00:27:48,480 +الماليجنانسي و غالبا بدوه symptomatic treatment + +351 +00:27:49,210 --> 00:27:53,370 +أتاكسيا تيلانجيكتازيا وترزومال ريسيسيف ديفيشانسي + +352 +00:27:53,370 --> 00:27:59,890 +DNA repair affecting D and B cell وصرف عنده + +353 +00:27:59,890 --> 00:28:04,090 +progressive ataxia تيلانجيكتازيا نعرف المصطلحات + +354 +00:28:04,090 --> 00:28:07,410 +هذه ataxia يعني jerky movement تيلانجيكتازيا يعني + +355 +00:28:07,410 --> 00:28:12,810 +شق في القوايا الدموية أو فتحات في القوايا الدموية + +356 +00:28:12,810 --> 00:28:16,750 +ورياب ال immunodeficiency يعني يصرف عنده recurrent + +357 +00:28:16,750 --> 00:28:23,190 +sinopalmonary infectionوهي عامة طبعا المرض منها + +358 +00:28:23,190 --> 00:28:26,510 +انه بيصير فيه زيادة في البرجنانسي لوكيميا اللوفين + +359 +00:28:26,510 --> 00:28:34,650 +hyper IgE او بيسموه job syndrome autosomalism + +360 +00:28:34,650 --> 00:28:42,170 +symptoms core facial features skeletal abnormality + +361 +00:28:42,170 --> 00:28:47,210 +or recurrent staph infection MBTU + +362 +00:28:48,610 --> 00:28:55,230 +Anemonia with Pneumatocele Formation وهي بيشتهر + +363 +00:28:55,230 --> 00:29:00,570 +هذا المرض بالـ 3 E's وهي الـ Elevated IgE + +364 +00:29:00,570 --> 00:29:10,190 +والإيزينوفيليا والإكزيما هذا ال IGM تسل ال + +365 +00:29:10,190 --> 00:29:16,410 +abnormality preventing IGM to اللي هو class which + +366 +00:29:16,410 --> 00:29:23,040 +to IGGفبصير فيه X-linked recessive الميال ستة شهور + +367 +00:29:23,040 --> 00:29:30,020 +لسنة تظهر عنده هذه الظعرات لأنه + +368 +00:29:30,020 --> 00:29:33,760 +X-linked frequent sinopelmonary infection ديارية + +369 +00:29:33,760 --> 00:29:37,820 +opportunistic infection و low level of IgG IgA + +370 +00:29:37,820 --> 00:29:41,420 +high level of IgM treatment immunoglobulin + +371 +00:29:41,420 --> 00:29:47,500 +replacement HIV هو بره ال retrovirus infectionلـ + +372 +00:29:47,500 --> 00:29:55,280 +CD4 بوزيتيف سالز و بيصير فيه Vertical Transmission + +373 +00:29:55,280 --> 00:30:05,280 +بصيب ل breast milk و Sex هو السبب و ال range of + +374 +00:30:05,280 --> 00:30:08,800 +clinical manifestation طبعا فيه failure to thrive, + +375 +00:30:09,040 --> 00:30:12,840 +fever, night sweating, malaria, recurrent rash or + +376 +00:30:12,840 --> 00:30:17,400 +recurrent bacteria infectionDecrease CD4 count may + +377 +00:30:17,400 --> 00:30:24,320 +have elevated immunoglobulin وده Structure طبعا كل + +378 +00:30:24,320 --> 00:30:28,120 +خطوة في ال Virology وده Serological Profile ودلش + +379 +00:30:28,120 --> 00:30:36,420 +ننسى Drop of CD4 وDrop of HIV Viral Load ويسمونها + +380 +00:30:36,420 --> 00:30:39,540 +Serological + +381 +00:30:39,540 --> 00:30:44,550 +Zoneبقل في المرحلة من المراحل اللي بدينا false + +382 +00:30:44,550 --> 00:30:48,350 +negative results.Pneumagogic abnormality بيحصل في + +383 +00:30:48,350 --> 00:30:50,350 +infection and destruction of dendritic cell, + +384 +00:30:50,470 --> 00:30:54,650 +microphage, and T-Helper cell، وlate decrease in T + +385 +00:30:54,650 --> 00:30:59,810 +-Helper cell number بيوصل لغاية 200 ملي متر لكل + +386 +00:30:59,810 --> 00:31:06,010 +blood.ال phagocytic disorder، بيحكي على neutrophil + +387 +00:31:06,010 --> 00:31:09,530 +function غالبا، phagocytes، وكنا بنعرف أنه ال + +388 +00:31:09,530 --> 00:31:13,760 +phagocytesيعني في بتعمل phagocytosis و ال + +389 +00:31:13,760 --> 00:31:18,400 +phagocytosis هم عبارة عن عدة مراحل أولها ال + +390 +00:31:18,400 --> 00:31:27,060 +adhesion ثم ال diabetes adhesion or adherence ثم + +391 +00:31:27,060 --> 00:31:37,780 +ال diabetes ثم اللي هو chemotaxis ثم ال engulfment + +392 +00:31:37,780 --> 00:31:41,500 +يعني phagocytosisثم المرحلة الأخيرة هي ال killing + +393 +00:31:41,500 --> 00:31:46,920 +فبالتالي ممكن يصير فيه خلل في أي مرحلة من المراحل + +394 +00:31:46,920 --> 00:31:51,300 +من أشهر الحالات المرضية اللي بتصيب ال phagocytosis + +395 +00:31:51,300 --> 00:31:54,760 +in general هو مرض بسمه chronic granulomatous + +396 +00:31:54,760 --> 00:31:58,760 +disease و ال chronic granulomatous disease هو + +397 +00:31:58,760 --> 00:32:03,200 +عبارة عن مرض بيصير فيه defective في الناد BH + +398 +00:32:03,200 --> 00:32:08,190 +اكسيديز و كلنا عارفين ان الناد BH هو عبارة عنهو + +399 +00:32:08,190 --> 00:32:11,730 +اللي بيطلعنا نت بي أتش نت بي أتش هي عبارة عن + +400 +00:32:11,730 --> 00:32:18,330 +reducing agent بتطرد any oxidant by continuous + +401 +00:32:18,330 --> 00:32:24,610 +reduction لها وبالتالي بيصير فيه إيش مانع ليه إيش + +402 +00:32:24,610 --> 00:32:28,150 +يعني + +403 +00:32:28,150 --> 00:32:35,880 +any oxidant و أُكر هلأ لما يصير خربهامش بس + +404 +00:32:35,880 --> 00:32:40,260 +الاربسيز بيصير فيها يعني الأكسيدان بيحمينا بيعمل + +405 +00:32:40,260 --> 00:32:44,300 +الاربسيز لكن وات بيسيز بيصير فيها اللي هو خلل في + +406 +00:32:44,300 --> 00:32:50,160 +ال ال electron donor acceptor system وبالتالي + +407 +00:32:50,160 --> 00:32:55,600 +بيصير فيه خلل في القتل هيانة وقدر انه خمسة وسبعين + +408 +00:32:55,600 --> 00:32:58,520 +في المية منه X-laying recessive وخمسة و عشرين في + +409 +00:32:58,520 --> 00:33:04,200 +المية منه autosomal recessive وبيشتهربـsevere + +410 +00:33:04,200 --> 00:33:08,700 +recurrent staph aureus infection ميكروب ضعيف لكنه + +411 +00:33:08,700 --> 00:33:12,860 +بيعمل recurrent infection of lymph nodes and skin + +412 +00:33:12,860 --> 00:33:19,400 +granulomas which is healed slowly ثم نومناط + +413 +00:33:19,400 --> 00:33:24,780 +نومونايتس and osteomyelitis وهيباطس بلينوميجا دي + +414 +00:33:24,780 --> 00:33:30,060 +والقائمة طول الdiagnosis بتتم خلال نيترو بلو + +415 +00:33:30,060 --> 00:33:34,130 +تيترازوليوم testهذه عبارة عن صبغة بنسبغ فيها + +416 +00:33:34,130 --> 00:33:38,530 +نيوتروفيل والله إذا صبغت النيوتروفيل بيكون فيه + +417 +00:33:38,530 --> 00:33:43,770 +إيش؟ بيكون خلية + +418 +00:33:43,770 --> 00:33:49,750 +functioning وإذا صارت black إذا تحول ال cytoplasm + +419 +00:33:49,750 --> 00:33:56,590 +ل black completely بنيته عملية القتل مش مورودة + +420 +00:33:56,590 --> 00:34:02,750 +treatment antimicrobial prophylaxisinterferon + +421 +00:34:02,750 --> 00:34:06,570 +gamma-unborn marrow transplantation المرض التاني + +422 +00:34:06,570 --> 00:34:08,970 +اللي هو الـ LAD disease leukocyte adhesion + +423 +00:34:08,970 --> 00:34:13,470 +deficiency disease طبعا في هذه الحالة من اسم الـ + +424 +00:34:13,470 --> 00:34:17,630 +adhesion الأول مرحلة من المراحل بيصير فيها خلال + +425 +00:34:17,630 --> 00:34:21,370 +طبعا بيصير فيه deficiency في كل مراحل + +426 +00:34:21,370 --> 00:34:27,040 +كيمفاجوسيتوسيز اللي بيبتريها زي ال chemotaxisوما + +427 +00:34:27,040 --> 00:34:32,980 +يليها recurrent soft infection او tissue infection + +428 +00:34:32,980 --> 00:34:39,300 +زى skin و respiratory و soft tissue كلهم بيصيروا + +429 +00:34:39,300 --> 00:34:43,660 +recurrent infection impaired wound healing جرح + +430 +00:34:43,660 --> 00:34:50,580 +بيبطل الطيب typically nobus و minimal inflammation + +431 +00:34:50,580 --> 00:34:56,340 +ماشيمن صفاته انه بيصير فيه delay الامبريكا + +432 +00:34:56,340 --> 00:34:59,680 +separation وهي بيصير فيه زيادة في ال white blood + +433 +00:34:59,680 --> 00:35:03,920 +cell و ال treatment by bone marrow transplantation + +434 +00:35:03,920 --> 00:35:09,080 +complement system disorders طبعا كلنا بنعرف انه في + +435 +00:35:09,080 --> 00:35:13,580 +عندنا عدد من ال complement أهمها أول تسعة من C1 ل + +436 +00:35:13,580 --> 00:35:17,840 +C4 وبالتالي سجلت حالات deficiency في ال complement + +437 +00:35:17,840 --> 00:35:23,360 +componentبالتالي اصبح هناك انفكاش من المريض + +438 +00:35:23,360 --> 00:35:27,080 +بكتيريا انكامسولية تبعًا موجودة في الانفكاش بشكل + +439 +00:35:27,080 --> 00:35:27,720 +متسابق لشخصية الانفكاش + +440 +00:35:27,720 --> 00:35:43,780 +الهيومينيوميونيوميونيوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميوميومي + +441 +00:35:45,860 --> 00:35:51,740 +معرفة من خلال الـ CH50 Functional Assay اللي يؤسس + +442 +00:35:51,740 --> 00:35:52,940 +مجموعة الكملمنت + +443 +00:36:06,430 --> 00:36:10,230 +يستخدم أيضًا جزء واحد للتعامل مع التعامل مع + +444 +00:36:10,230 --> 00:36:10,830 +التعامل مع التعامل مع التعامل مع التعامل مع + +445 +00:36:10,830 --> 00:36:11,370 +التعامل مع التعامل مع التعامل مع التعامل مع + +446 +00:36:11,370 --> 00:36:13,010 +التعامل مع التعامل مع التعامل مع التعامل مع + +447 +00:36:13,010 --> 00:36:14,470 +التعامل مع التعامل مع التعامل مع التعامل مع + +448 +00:36:14,470 --> 00:36:14,970 +التعامل مع التعامل مع التعامل مع التعامل مع + +449 +00:36:14,970 --> 00:36:15,010 +التعامل مع التعامل مع التعامل مع التعامل مع + +450 +00:36:15,010 --> 00:36:15,010 +التعامل مع التعامل مع التعامل مع التعامل مع + +451 +00:36:15,010 --> 00:36:15,010 +التعامل مع التعامل مع التعامل مع التعامل مع + +452 +00:36:15,010 --> 00:36:18,690 +التعامل مع التعامل مع التعامل مع التعامل مع + +453 +00:36:18,690 --> 00:36:32,130 +التعامل مع التعامل مع التعامل مع التعامل مع + +454 +00:36:32,260 --> 00:36:37,260 +هو Chemical Explosion and HIV Effect Immune System + +455 +00:36:37,260 --> 00:36:44,300 +By Eliminating CD4-T Lymphocyte ونشكر لكم حسن + +456 +00:36:44,300 --> 00:36:45,400 +الاستماع + diff --git a/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/NSVahW18bdQ.srt b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/NSVahW18bdQ.srt new file mode 100644 index 0000000000000000000000000000000000000000..ff32bb4bdb7070f7687b7481bf0a0ffd5b6a4386 --- /dev/null +++ b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/NSVahW18bdQ.srt @@ -0,0 +1,1199 @@ +1 +00:00:02,260 --> 00:00:06,260 +بسم الله الرحمن الرحيم اليوم إن شاء الله محاضرتنا + +2 +00:00:06,260 --> 00:00:13,360 +عن الفحوصات التي تعتمد على الـ Antibody reaction و + +3 +00:00:13,360 --> 00:00:19,640 +دي محاضرة تقريبا أنا بعتبرها محاضرة مراجعة لأنه + +4 +00:00:19,640 --> 00:00:25,010 +أكيد بعد ما وصلت لهذا المستوى العلمي في السنة الرابعة + +5 +00:00:25,010 --> 00:00:29,510 +أكيد مررت بكل هذه الفحوصات شو طبيعة التفاعل بين + +6 +00:00:29,510 --> 00:00:31,570 +الـ Antigen والـ Antibody الـ Reaction؟ قال الطبيعة + +7 +00:00:31,570 --> 00:00:35,610 +التفاعل يعتمد على نظرية lock and key theory + +8 +00:00:35,610 --> 00:00:40,350 +concept or theory الترابطات اللي موجودة هي بره non + +9 +00:00:40,350 --> 00:00:44,570 +-covalent bonding و الـ Non-covalent bonding خدتوها + +10 +00:00:44,570 --> 00:00:48,270 +زي الهيدروجين الـ Electrostatic و Vander wall and + +11 +00:00:48,270 --> 00:00:53,120 +hydrophobic bonding الروابط هي عبارة عن multiple + +12 +00:00:53,120 --> 00:01:03,500 +bonds and it's reversible لأنها ضعيفة مصطلح أخدته + +13 +00:01:03,500 --> 00:01:09,540 +هو Affinity وهي عبارة عن يمثل هذا المصطلح قوة + +14 +00:01:09,540 --> 00:01:15,040 +الرابط ما بين Antigen و Antibody between single + +15 +00:01:15,040 --> 00:01:17,700 +antigenic determinant يعني Single Epitope and + +16 +00:01:17,700 --> 00:01:22,240 +single antibody combining sites هذه الـ Affinity + +17 +00:01:22,240 --> 00:01:27,180 +ارتباط One Epitope بـ One Fab One Epitope بـ One Fab + +18 +00:01:27,180 --> 00:01:35,990 +الصورة هذه بتبين إن الـ Affinity هنا عالية كل روابط + +19 +00:01:35,990 --> 00:01:42,190 +هي عبارة عن روابط تجاذبية + +20 +00:01:42,190 --> 00:01:46,510 +بينما هنا في عندنا روابط تنافرية زي ما أنتم شايفين + +21 +00:01:46,510 --> 00:01:55,250 +قدّت إلى Low Affinity of Binding ال + +22 +00:01:55,250 --> 00:01:59,250 +Calculation of Affinity أخدتوها طبعا من خلال اللي + +23 +00:01:59,250 --> 00:02:03,090 +هو القانون هذا Antigen زائد Antibody يساوي Antibody + +24 +00:02:03,090 --> 00:02:10,650 +Reaction الـ Applying of Law of Mass Action اللي هو + +25 +00:02:10,650 --> 00:02:13,430 +من خلال حساب الـ K equivalent بيساوي الـ Antigen + +26 +00:02:13,430 --> 00:02:17,550 +-Antibody على الـ Antigen في الـ Antibody Avidity + +27 +00:02:17,550 --> 00:02:28,390 +هي برعنة مجموع الروابط ما بين الـ Antigen بكل الـ + +28 +00:02:28,390 --> 00:02:33,920 +Epitopes تبعته مع الـ Multivalent Antibody فهذه + +29 +00:02:33,920 --> 00:02:38,700 +عبارة عن Affinity رابطة Fab مع One Epitope هذه + +30 +00:02:38,700 --> 00:02:44,040 +عبارة عن Affinity to Fab مع Epitope مع Two Epitopes + +31 +00:02:44,040 --> 00:02:50,820 +وشايفين المجموع صار عشرة للقوة ستة طبعا في حالة الـ + +32 +00:02:50,820 --> 00:02:55,580 +IgM هذا هي برضه الـ Affinity عشرة صارت للقوة عشرة + +33 +00:02:55,580 --> 00:03:00,860 +Specificity هي قدرة الارتباط One Individual + +34 +00:03:02,180 --> 00:03:09,760 +Antibody Fab Antibody Fab Antibody + +35 +00:03:09,760 --> 00:03:12,520 +Antibody Antibody Antibody Antibody Antibody + +36 +00:03:12,520 --> 00:03:13,780 +Antibody Antibody Antibody Antibody Antibody + +37 +00:03:13,780 --> 00:03:16,080 +Antibody Antibody Antibody Antibody Antibody + +38 +00:03:16,080 --> 00:03:18,700 +Antibody Antibody Antibody Antibody Antibody + +39 +00:03:18,700 --> 00:03:19,260 +Antibody Antibody Antibody Antibody Antibody + +40 +00:03:19,260 --> 00:03:19,760 +Antibody Antibody Antibody Antibody Antibody + +41 +00:03:19,760 --> 00:03:28,640 +Antibody Antibody Antibody Antibody Antibody Anti + +42 +00:03:28,640 --> 00:03:32,560 +react with more than one antigenic determinant الـ + +43 +00:03:32,560 --> 00:03:35,940 +Antigenic Determinant اسمه القديم للـ Epitopes يعني + +44 +00:03:35,940 --> 00:03:39,660 +واحد Antibody ممكن يتفاعل مع أكثر من Epitope أو + +45 +00:03:39,660 --> 00:03:43,400 +مجموعة من الـ Antibody تتفاعل مع أكثر من إيش One + +46 +00:03:43,400 --> 00:03:47,500 +Antigen زي ما أنتم شايفين إن الـ Anti-A Antibody + +47 +00:03:47,500 --> 00:03:53,880 +تفاعل مع الـ Antigen A نفس الـ Antibody A تفاعل مع + +48 +00:03:53,880 --> 00:03:59,190 +الـ Antigen P في حالة Shared Epitope أو Similar + +49 +00:03:59,190 --> 00:04:04,230 +Epitope أيضًا الـ Anti-A تفاعل مع الـ Antigen-C + +50 +00:04:04,230 --> 00:04:08,290 +طبعا في هذه الحالة في Cross-Reaction ما بين الـ B + +51 +00:04:08,290 --> 00:04:12,510 +-Antigen والـ C-Antigen مع الـ Anti-A Antibody + +52 +00:04:12,510 --> 00:04:18,110 +اللي هو Anti-A يبقى ما هي العوامل التي تؤثر في قياس + +53 +00:04:18,110 --> 00:04:20,250 +الـ Antigen-Antibody Reaction جالكم الـ Affinity + +54 +00:04:20,250 --> 00:04:23,490 +والـ Avidity وحكيناها الـ Antigen-Antibody Ratio + +55 +00:04:23,920 --> 00:04:29,440 +طبعا برضه هذه النقطة مهمة و الـ Antigen-Antibody + +56 +00:04:29,440 --> 00:04:35,160 +Ratio طبعا هنا يوم يكون فيه Antibody Excess هيكون + +57 +00:04:35,160 --> 00:04:38,440 +فيه أكثر + +58 +00:04:38,440 --> 00:04:45,400 +من Antibody أو يوم يكون فيه Antigen Excess طبعا في + +59 +00:04:45,400 --> 00:04:53,100 +هذه الحالة سموها Prozone Phenomena طبعا أهم حاجة دي + +60 +00:04:53,100 --> 00:04:57,180 +ما بيحصل فيها لبروزون فنومينا هو إن يكون فيه + +61 +00:04:57,180 --> 00:05:02,840 +Equivalence يكون فيه عدد كافي من الـ Fab يرتبط مع + +62 +00:05:02,840 --> 00:05:07,980 +الـ Epitope Physical Form of Antigen الـ Odor هل + +63 +00:05:07,980 --> 00:05:14,060 +هو Soluble ولا Precipitate كمان الـ Odor فيه Epitope طيب + +64 +00:05:14,060 --> 00:05:16,580 +ما هي الفحوصات التي تعتمد على Antigen بعد الـ + +65 +00:05:16,580 --> 00:05:21,780 +Reaction؟ جالكم الفحوصات اللي بتعتمد على Antigen + +66 +00:05:21,780 --> 00:05:27,560 +-Antibody Reaction هتعتمد على Lattice Formation أو + +67 +00:05:27,560 --> 00:05:33,380 +هم هتحتاجوا لاستخدام طرح لتحريك مجموعات أمينية + +68 +00:05:33,380 --> 00:05:38,140 +صغيرة طبعا كل الفحوصات اللي بتعتمد على Antigen + +69 +00:05:38,140 --> 00:05:40,600 +-Antibody Reaction Can Be Used To Detect Either + +70 +00:05:40,600 --> 00:05:45,340 +Antigen Or Antibody وأول قائمة من هذه الفحوصات هي + +71 +00:05:45,340 --> 00:05:48,180 +الـ Agglutination By Using A Lattice Formation + +72 +00:05:48,180 --> 00:05:52,980 +Agglutination Or Hemagglutination By Definition + +73 +00:05:52,980 --> 00:05:57,220 +These Are Tests That Have Their End Point + +74 +00:05:57,220 --> 00:06:03,420 +Agglutination Of Particular Antigen يعني محصلة هذه + +75 +00:06:03,420 --> 00:06:07,460 +التفاعل In The Sphere Of Agglutination ماشي سواء + +76 +00:06:07,460 --> 00:06:11,680 +كان Agglutin By Agglutin Or Hemagglutin + +77 +00:06:12,850 --> 00:06:16,910 +طبعا دي صار Qualitative Agglutination Test ده هو + +78 +00:06:16,910 --> 00:06:19,630 +حطينا Antigen مع Antibody على Slide داي Antigen + +79 +00:06:19,630 --> 00:06:23,830 +-Antibody Reaction محصلة Agglutination Or Can Be + +80 +00:06:23,830 --> 00:06:28,230 +Quantitative يوم ما استخدمي اللي هو الـ Titer + +81 +00:06:28,230 --> 00:06:33,130 +Technique ماشي و الـ Titer طبعا بس بدي آخد في عين + +82 +00:06:33,130 --> 00:06:36,210 +اعتبار الـ Prozone Phenomena الـ Titer Technique + +83 +00:06:36,210 --> 00:06:42,720 +إني أخفف الـ Antigen أو الـ Antibody ماشي In + +84 +00:06:42,720 --> 00:06:46,940 +Different Wells و أحط الـ Antigen أو الـ Antibody + +85 +00:06:46,940 --> 00:06:51,840 +على الـ Well بغض النظر سواء كان الـ Antigen مطلوب + +86 +00:06:51,840 --> 00:06:57,980 +قياسه أو الـ Antibody مطلوب قياسه بنحطه على الـ Well + +87 +00:06:57,980 --> 00:07:05,720 +و بنشوف آخر Titer أعطانا Negative يكون الـ + +88 +00:07:05,720 --> 00:07:08,400 +Concentration Of الـ Antibody أو الـ Antigen هو + +89 +00:07:08,400 --> 00:07:10,420 +التركيز اللي قبله + +90 +00:07:13,470 --> 00:07:17,270 +It Could Be Qualitative و Could Be Quantitative من + +91 +00:07:17,270 --> 00:07:22,870 +الـ Application تبعتها و Blood Typing Or Bacterial + +92 +00:07:22,870 --> 00:07:28,050 +Infection و ما أكثرها ماشي و كل في الـ .. إذا بدنا + +93 +00:07:28,050 --> 00:07:34,050 +نعمل و Quantitative نعمل اللي هو Titers زي ما قلنا + +94 +00:07:34,050 --> 00:07:40,530 +الـ Fourfold Rises In Titers ده هو اثنين أربعة + +95 +00:07:40,530 --> 00:07:46,430 +ثمانية ستة عشر واحدكذا الـ Practical Consideration + +96 +00:07:46,430 --> 00:07:51,590 +بسهولة لكنها ما بتعطينا Result Quantitative وإنما + +97 +00:07:51,590 --> 00:07:55,490 +Semi-Quantitative Passive Agglutination أو + +98 +00:07:55,490 --> 00:08:01,830 +Hemagglutination By Definition في هذه الحالة بنعمل + +99 +00:08:01,830 --> 00:08:03,790 +Test Done With Solid + +100 +00:08:09,070 --> 00:08:16,790 +الـ Antigen كوّانت ماشي لأنه Soluble وبالتالي بعد هيك + +101 +00:08:16,790 --> 00:08:19,410 +بنحط عليها الـ Antibody فالـ Antibody برتبط + +102 +00:08:19,410 --> 00:08:23,870 +بالـ Antigen اللي على الـ Beads ماشي وبالتالي أو على + +103 +00:08:23,870 --> 00:08:28,090 +Wells لغاية النظر وبالتالي بدي نعيش اللي هو + +104 +00:08:28,090 --> 00:08:30,590 +التفاعل Application Measurement Of Antibody To + +105 +00:08:30,590 --> 00:08:32,350 +Soluble Antigen + +106 +00:08:36,390 --> 00:08:39,210 +طبعا كما تعرفون بإمكاننا اختيار الـ Incomplete + +107 +00:08:39,210 --> 00:08:43,150 +Antibody في حالة الـ Direct Combs Test يعني الـ + +108 +00:08:43,150 --> 00:08:50,010 +Opsinin نشوف إذا كان فيه Antibody على سطح خلية + +109 +00:08:50,010 --> 00:08:53,810 +الدم الحمراء وطبعا الـ Direct فقط كل ما هناك إنه + +110 +00:08:53,810 --> 00:08:57,650 +بتحط الـ Patient RBCs اللي على سطحها Opsinin مع + +111 +00:08:57,650 --> 00:09:02,370 +Anti-Human Antibody اللي هو الـ Combs Reagent و + +112 +00:09:02,370 --> 00:09:07,000 +الـ Inderect بندور على Anti + +113 +00:09:07,000 --> 00:09:12,440 +-Erythrocyte Antibody In Serum وبالتالي بحتاج + +114 +00:09:12,440 --> 00:09:18,500 +لخطوة إضافية نجيب الـ Patient Serum و بنحط عليه + +115 +00:09:18,500 --> 00:09:26,940 +RBCs With Non-Antigen ماشي و بنعمل Incubation إذا + +116 +00:09:26,940 --> 00:09:30,180 +كان الـ Antibody موجود في الـ Serum تبع المريض بيصير + +117 +00:09:30,180 --> 00:09:36,860 +فيه Coating للـ RBCs With Antibody بعد ذلك نستخدم + +118 +00:09:36,860 --> 00:09:42,980 +الـ Combs Reagent فبدينا اللي هو الـ Positive Reaction + +119 +00:09:42,980 --> 00:09:45,280 +إذا الـ Antibody موجود في الـ Patient Serum + +120 +00:09:45,280 --> 00:09:49,860 +Application Detection و Anti-Array أو في الـ + +121 +00:09:49,860 --> 00:09:53,900 +Autoimmune Hemolytic Anemia الـ Agglutination هي الـ + +122 +00:09:53,900 --> 00:10:01,640 +Agglutination نوع آخر By Definition Usually الـ فحص + +123 +00:10:01,640 --> 00:10:06,300 +يعتمد على الـ Inhibition أو الـ Precipitation نتيجة إيش نتيجة + +124 +00:10:06,300 --> 00:10:09,580 +Competition With A Soluble Antigen يعني في هذه + +125 +00:10:09,580 --> 00:10:15,260 +الحالة الـ Negative Positive و الـ Positive Negative + +126 +00:10:15,260 --> 00:10:20,500 +هي الـ Prior Testing كل ما هناك إنه نحط الـ Antibody + +127 +00:10:20,500 --> 00:10:30,420 +مع الـ Coated Antigen فبرتبط الـ Antibody بالـ Antigen + +128 +00:10:31,430 --> 00:10:37,230 +بعد هيك بنحط الـ Serum تبع المريض ماشي في هذه + +129 +00:10:37,230 --> 00:10:43,250 +الحالة الـ Serum تبع المريض إذا فيه Antigen + +130 +00:10:43,250 --> 00:10:53,450 +هرتبط مع بقايا الـ Antibody اللي موجودة هيتفاعل + +131 +00:10:53,450 --> 00:10:56,740 +مع الـ Antibody اللي موجودة وبالتالي سيكون هناك + +132 +00:10:56,740 --> 00:11:01,180 +تنافس ما بين الـ Antigen الـ Coated و الـ Antigen الـ + +133 +00:11:01,180 --> 00:11:03,640 +Free اللي موجود في الـ Patient و يديني Positive + +134 +00:11:03,640 --> 00:11:10,860 +Reaction طبعا هذا في حالة إيش في حالة وجود Antigen + +135 +00:11:10,860 --> 00:11:13,800 +عند المريض ما فيش Antigen بدينا إيش في هذه الحالة + +136 +00:11:13,800 --> 00:11:18,000 +Already محصول الـ Antibody وبالتالي Inhibited من + +137 +00:11:18,000 --> 00:11:23,880 +التفعيل من أولى Agglutination Application مجرم + +138 +00:11:23,880 --> 00:11:28,580 +التواصل بالـ Antigen الـ Practical Consideration زيها + +139 +00:11:28,580 --> 00:11:33,640 +زي الـ Agglutination العائلة الثانية من الفحوصات هي + +140 +00:11:33,640 --> 00:11:38,500 +الـ Precipitation Tests و طبعا منها Radial + +141 +00:11:38,500 --> 00:11:42,740 +immunodiffusion أو الـ Manson وزي ما أنتم شايفين + +142 +00:11:42,740 --> 00:11:53,780 +إحنا بنجيب slice غالباً أو agar plate من الجل وفي + +143 +00:11:53,780 --> 00:12:02,490 +اللي هو بنحط الـ antigen ماشي + +144 +00:12:02,490 --> 00:12:08,590 +in طبعاً الـ antibody موجود في إيش؟ في الجل + +145 +00:12:08,590 --> 00:12:14,050 +embedded in the gel وبنحط الـ antigen في إيش؟ في + +146 +00:12:14,050 --> 00:12:17,690 +الفتحات + +147 +00:12:17,690 --> 00:12:22,350 +تبعته طبعاً في هذه الحالة الـ diameter هيتشير في + +148 +00:12:22,350 --> 00:12:26,360 +تفاعل بين الـ antigen والـ antibody والـ diameter is + +149 +00:12:26,360 --> 00:12:32,240 +directly related to the concentration of اللي هو + +150 +00:12:32,240 --> 00:12:35,500 +antigen + +151 +00:12:35,500 --> 00:12:38,900 +أو + +152 +00:12:38,900 --> 00:12:44,320 +الـ immunoglobulin إذا بننظر على antibody هذا هو دي + +153 +00:12:44,320 --> 00:12:46,860 +straight line antigen concentration مع الـ diameter + +154 +00:12:46,860 --> 00:12:52,600 +square دي straight line electrophoresis نفس الحكاية + +155 +00:12:52,600 --> 00:12:57,020 +بس في هذه الحالة بدنا تيار كهربائي الـ antigen are + +156 +00:12:57,020 --> 00:13:00,920 +separated by electrophoresis بنحطه في شجة والـ + +157 +00:13:00,920 --> 00:13:06,780 +electrophoresis طبعاً بيكون في عندنا current تيار + +158 +00:13:06,780 --> 00:13:11,530 +كهربائي وبالتالي بيصير فيه movement للـ antigen للـ + +159 +00:13:11,530 --> 00:13:18,050 +antigen حسب الـ charge والـ antigen والتيار الكهربائي + +160 +00:13:39,400 --> 00:13:44,260 +يهاجر باتجاه الـ antibody ويعملنا إيش الـ arc اللي زي + +161 +00:13:44,260 --> 00:13:48,600 +ما أنتم شايفينه في الـ arc هذا represent individual + +162 +00:13:48,600 --> 00:13:54,920 +antigen اللي موجودة qualitative + +163 +00:13:54,920 --> 00:13:59,140 +relative concentration counter current counter + +164 +00:13:59,140 --> 00:14:04,920 +current يعني two اللي هو هذا هو بـ antigen و antibody + +165 +00:14:04,920 --> 00:14:08,200 +بنحطه بالبعد في تيار كهربائي فالاثنين بيهاجروا + +166 +00:14:08,200 --> 00:14:13,270 +باتجاه بعيد وبندونة straight line أو في المصدر اللي + +167 +00:14:13,270 --> 00:14:18,770 +هو بدنا التفاعل antigen و antibody يتحولوا إلى + +168 +00:14:18,770 --> 00:14:23,190 +بعضهم البعض في الـ paper of research طبعاً هذا إيه + +169 +00:14:23,190 --> 00:14:29,190 +بتستخدمه لما antigen و antibody يكونوا بيحملوا + +170 +00:14:29,190 --> 00:14:36,610 +شحنات مختلفة مش qualitative لكنها rapid الريا والـ + +171 +00:14:36,610 --> 00:14:42,560 +enzyme أو الـ ELISA competitive rea or إليزا من الاسم + +172 +00:14:42,560 --> 00:14:49,480 +competitive بمعنى منافسة بنقيس + +173 +00:14:49,480 --> 00:14:55,500 +من خلالها الـ amount of antibody needed to bind + +174 +00:14:55,500 --> 00:14:59,560 +known amount of labelled antigen كمية معروفة بالـ + +175 +00:14:59,560 --> 00:15:04,990 +antigen وماشي وبتقيص أنت كمية الـ antibody اللي + +176 +00:15:04,990 --> 00:15:09,710 +استهلكتها خلصت عليها هذا بيصير فيه تفاعل بين الـ + +177 +00:15:09,710 --> 00:15:14,550 +antigen والـ antibody وبعد هيك بنحط الـ patient + +178 +00:15:14,550 --> 00:15:19,430 +serum طبعاً إحنا في هذا الحاجة بنستخدم + +179 +00:15:19,430 --> 00:15:22,550 +predetermined amount of labelled antigen عرفناها + +180 +00:15:22,550 --> 00:15:27,330 +قبل هيك مع الـ antibody وبعد هيك بنضيف الـ sample + +181 +00:15:27,330 --> 00:15:30,270 +patient sample + +182 +00:15:36,010 --> 00:15:39,270 +التفاعل اللي صار في الأول ما بين labelled antigen + +183 +00:15:39,270 --> 00:15:46,070 +وما بين antibody لكن patient sample or antigen is + +184 +00:15:46,070 --> 00:15:51,430 +not labelled فبيصير في تنافس ما بين مين ما بين الـ + +185 +00:15:51,430 --> 00:15:59,010 +antigen اللي labelled والـ antigen اللي موجود في + +186 +00:15:59,010 --> 00:16:02,830 +الـ patient serum طبعاً في الأول إحنا عرفنا كده كمية + +187 +00:16:02,830 --> 00:16:07,440 +الـ antigen بنقيسها في الأول وبنقيسها في الآخر كده + +188 +00:16:07,440 --> 00:16:11,280 +بينقص الـ concentration ماشي بيكون هو عبارة عن + +189 +00:16:11,280 --> 00:16:18,320 +concentration of patient sample competitive real + +190 +00:16:18,320 --> 00:16:23,020 +or realizer I determine the amount of labelled + +191 +00:16:23,020 --> 00:16:28,040 +antigen bound to antibody نستخدم اللي هو an H + +192 +00:16:28,040 --> 00:16:31,480 +force SO4 + +193 +00:16:34,980 --> 00:16:38,560 +مع الـ Anti-Immunoglobulin في Immobilized + +194 +00:16:38,560 --> 00:16:44,740 +الـ antibody هذا هو نفس الحكاية زي ما قلنا labelled + +195 +00:16:44,740 --> 00:16:49,820 +antigen مع antibody بنشوف الكمية وبنقيس بعد هيك + +196 +00:16:49,820 --> 00:16:56,440 +بنضيف الـ patient sample هو بيصير فيه تفاعل ما بين + +197 +00:16:56,440 --> 00:17:01,830 +الـ patient sample والـ antibody فبيخس كمية القيش بقل + +198 +00:17:01,830 --> 00:17:12,550 +الـ concentration of labelled antigen انتجب انتجب + +199 +00:17:12,550 --> 00:17:15,950 +انتجب انتجب انتجب انتجب انتجب انتجب انتجب انتجب + +200 +00:17:15,950 --> 00:17:16,070 +انتجب انتجب انتجب انتجب انتجب انتجب انتجب انتجب + +201 +00:17:16,070 --> 00:17:19,050 +انتجب انتجب انتجب انتجب انتجب انتجب انتجب انتجب + +202 +00:17:19,050 --> 00:17:26,170 +انتجب بنعرف من خلال أو من خلال طبعاً قبلها جبنا نعمل + +203 +00:17:26,170 --> 00:17:30,350 +اللي هو start our care with known amount of lab of + +204 +00:17:30,350 --> 00:17:31,070 +lab of lab of lab of lab of lab of lab of lab of + +205 +00:17:31,070 --> 00:17:31,470 +lab of lab of lab of lab of lab of lab of lab of + +206 +00:17:31,470 --> 00:17:31,570 +lab of lab of lab of lab of lab of lab of lab of + +207 +00:17:31,570 --> 00:17:31,990 +lab of lab of lab of lab of lab of lab of lab of + +208 +00:17:31,990 --> 00:17:34,850 +lab of lab of lab of lab of lab of lab of lab of + +209 +00:17:34,850 --> 00:17:37,810 +lab of lab of lab of lab of lab of lab of lab of + +210 +00:17:37,810 --> 00:17:41,250 +lab of lab طبعاً الـ antibody detection ده هو نحطه + +211 +00:17:41,250 --> 00:17:45,350 +solid phase على سطحه immobilized antigen نحط الـ + +212 +00:17:45,350 --> 00:17:49,910 +antibody وبعد هيك نحط anti antibody اللي هو + +213 +00:17:49,910 --> 00:17:54,990 +labelled طبعاً صار flores معناته already كان فيه + +214 +00:17:54,990 --> 00:17:59,730 +تفاعل وصار فيه عيش قياس لـ flores and I + +215 +00:18:03,070 --> 00:18:07,470 +طبعاً هذا ممكن يكون quantitative على solid phase + +216 +00:18:07,470 --> 00:18:13,670 +ممكن كمان تستخدم إيه الـ antibody هذا الـ antigen وبعدين + +217 +00:18:13,670 --> 00:18:16,170 +نشوف إذا كان الـ antigen موجود في الـ patient + +218 +00:18:16,170 --> 00:18:20,090 +sample إذا صار فيه تفاعل هذا هو صار فيه تفاعل ما + +219 +00:18:20,090 --> 00:18:21,850 +بين الـ antigen والـ antibody اللي على الـ solid + +220 +00:18:21,850 --> 00:18:26,550 +phase بعدين بنحط labelled antibody هيتفاعل مع مين + +221 +00:18:26,550 --> 00:18:33,580 +مع الـ antigen اللي already ممسوك بالـ antibody ع + +222 +00:18:33,580 --> 00:18:37,420 +الـ antigen اللي already مشوق بالـ antigen طبعاً لما + +223 +00:18:37,420 --> 00:18:41,480 +أتوا labelled antibody اللي بترتبط is proportional + +224 +00:18:41,480 --> 00:18:46,060 +to the amount of ash of antigen in the sample تكون + +225 +00:18:46,060 --> 00:18:52,020 +معروفة أو قيمته جابل وقيمته بعيد ويكون ash الفرق + +226 +00:18:52,020 --> 00:18:55,680 +هو الـ concentration of antigen أو of antibody used + +227 +00:18:55,680 --> 00:18:59,180 +it's quantitative طبعاً + +228 +00:19:03,030 --> 00:19:08,710 +هنا آخر test for cell associated antigen وهنا الـ + +229 +00:19:08,710 --> 00:19:11,670 +lattice formation is not required إنها + +230 +00:19:11,670 --> 00:19:15,370 +immunofluorescent طبعاً في هذه الحالة بنستخدم + +231 +00:19:15,370 --> 00:19:20,850 +tissue مابناش خلايا وtissue طبعاً هذا إيه tissue + +232 +00:19:20,850 --> 00:19:24,950 +section لسطحه antigen بنحط عليه labelled antibody + +233 +00:19:24,950 --> 00:19:33,900 +ونشوفها باستخدام ميونوفلورقروم باستخدام + +234 +00:19:33,900 --> 00:19:35,540 +ميونوفلورقروم باستخدام ميونوفلورقروم باستخدام + +235 +00:19:35,540 --> 00:19:38,740 +ميونوفلورقروم باستخدام ميونوفلورقروم باستخدام + +236 +00:19:38,740 --> 00:19:40,320 +ميونوفلورقروم باستخدام ميونوفلورقروم باستخدام + +237 +00:19:40,320 --> 00:19:42,680 +ميونوفلورقروم باستخدام ميونوفلورقروم باستخدام + +238 +00:19:42,680 --> 00:19:47,260 +ميونوفلورقروم باستخدام ميونوفلورقروم باستخدام + +239 +00:19:47,260 --> 00:19:51,660 +ميونوفلورقروم باستخدام ميونوفلورقر + +240 +00:19:54,550 --> 00:19:59,850 +it's qualitative to semi quantitative flow + +241 +00:19:59,850 --> 00:20:04,970 +cytometry طبعاً هنا بنستخدم خلايا بنعملها + +242 +00:20:04,970 --> 00:20:10,510 +suspension فبالتالي بنعمل suspension للخلايا في + +243 +00:20:10,510 --> 00:20:15,090 +المحلول وبنعملها labeling with a fluorescent tag + +244 +00:20:15,090 --> 00:20:16,790 +و + +245 +00:20:18,370 --> 00:20:24,470 +بنقيص direct و indirect fluorescence ده هي طبعاً + +246 +00:20:24,470 --> 00:20:30,770 +بنمرجها flow ده هو بسموه flow flow قياس الخلايا + +247 +00:20:30,770 --> 00:20:36,050 +اللي بتمر in a flow طبعاً بنخليها تقطع laser beam + +248 +00:20:36,050 --> 00:20:39,410 +ويوم ما يشير في قطع للـ laser beam يشير في + +249 +00:20:39,410 --> 00:20:43,830 +scattering للـ light of the usual laser طبعاً هذا الـ + +250 +00:20:43,830 --> 00:20:49,210 +scattering يقاس by detector according to the usual + +251 +00:20:49,210 --> 00:20:54,690 +cell هي + +252 +00:20:54,690 --> 00:20:59,870 +cell analyzed on a flow cytometry قرأت النتاج أما + +253 +00:20:59,870 --> 00:21:07,850 +عن طريق histogram أو عن طريق اللي هو الـ quorum + +254 +00:21:12,660 --> 00:21:17,040 +فحصها بتعتمد على الـ complement برضه الـ lattice is + +255 +00:21:17,040 --> 00:21:20,460 +not required فحص كتير مشهور اسمه complement + +256 +00:21:20,460 --> 00:21:27,780 +fixation test والـ methods antigen is mixed with + +257 +00:21:27,780 --> 00:21:32,640 +test serum to be assayed for antibody يعني إحنا + +258 +00:21:32,640 --> 00:21:36,500 +بندور على antibody كيف يتم هذا الفحص؟ من هنا يبقى + +259 +00:21:36,500 --> 00:21:37,260 +مبين + +260 +00:21:59,140 --> 00:22:07,610 +الـ antigen يتفاعل مع الـ antibody إذا لم يكن موجود، + +261 +00:22:07,610 --> 00:22:12,410 +فإن الـ antibody سيبقى فالت ثم نضيف الـ complement + +262 +00:22:12,410 --> 00:22:15,990 +في الأنبوبة اللي فيها Anti Antibody Reaction الـ + +263 +00:22:15,990 --> 00:22:21,810 +complement ستتنشط وتستهلك ماشي فبيصير فيه + +264 +00:22:21,810 --> 00:22:29,650 +Utilization للـ complement ثم لو حطينا Coated RBCs + +265 +00:22:29,650 --> 00:22:39,950 +with Antibody ماذا سيحصل؟ فدالة الـ RBCs زي ما هي في + +266 +00:22:39,950 --> 00:22:44,130 +الأنبوبة اللي مافيش فيها اللي فيها اللي صار فيها + +267 +00:22:44,130 --> 00:22:47,090 +تفاعل ما بين الـ antigen والـ antibody يعني الـ + +268 +00:22:47,090 --> 00:22:51,010 +complement already خلصت وبالتالي مش راح تتفاعل و + +269 +00:22:51,010 --> 00:22:55,010 +بالتالي الـ RBCs مش راح تتكسر لكن في الأنبوبة اللي + +270 +00:22:55,010 --> 00:23:01,110 +مافيش فيها antigen الـ complement هتتمشط وبما أنه + +271 +00:23:01,110 --> 00:23:06,540 +حطينا coated RBCs هيبقى حتى تفاعل ما هتعملها + +272 +00:23:06,540 --> 00:23:10,600 +hemolysis فيوم ما يحصل في hemolysis معناته مافيش + +273 +00:23:10,600 --> 00:23:17,220 +antigen من الأساس negative لكن يوم ما يكون في يوم ما + +274 +00:23:17,220 --> 00:23:21,780 +يكون في hemolysis معناته it's negative result ويوم + +275 +00:23:21,780 --> 00:23:24,760 +ما يكون فيش hemolysis معناته positive result + +276 +00:23:24,760 --> 00:23:30,440 +نجيتها على السريع أنبوب ثاني واحدة فيها antibody + +277 +00:23:30,440 --> 00:23:35,740 +نبدأ من الثاني تتم فيهم antibody ونضيف الـ antigen + +278 +00:23:35,740 --> 00:23:40,040 +على واحدة منهم طبعاً الـ antigen هيتفاعل مع الـ + +279 +00:23:40,040 --> 00:23:44,660 +antibody إذا موجود والله بعد هيك بنضيف الـ + +280 +00:23:44,660 --> 00:23:48,880 +complement والـ complement في الأنبوبة اللي فيها + +281 +00:23:48,880 --> 00:23:52,840 +antigen antibody reaction هتستهلك تتمشك في وجود ال + +282 +00:23:52,840 --> 00:23:57,720 +AS antibody complex فبالتالي هتخلص بينما في + +283 +00:23:57,720 --> 00:24:00,600 +الأنبوبة اللي ماظهر فيها antigen antibody reaction + +284 +00:24:02,540 --> 00:24:06,460 +بعد ذلك نضيف ال indicator اللي هو عبارة عن coated + +285 +00:24:06,460 --> 00:24:12,060 +RBCs ماشي إلا في الأنبوبة اللي حصل فيها Anti + +286 +00:24:12,060 --> 00:24:16,840 +body Reaction مابتتأثر لأن ال complement اللي + +287 +00:24:16,840 --> 00:24:21,880 +حطناها أصلا خلصت وبالتالي مش راح تتنشط بينما في + +288 +00:24:21,880 --> 00:24:24,580 +الانبوبة اللي ما فيها Antigen Antibody Reaction + +289 +00:24:24,580 --> 00:24:29,660 +الـ complement هتفضل زي ما هي فيوم نحط Coated + +290 +00:24:29,660 --> 00:24:35,010 +RBCs اللي عبارة عن Antigen ماشي + +291 +00:24:35,010 --> 00:24:40,310 +حطنا هينشط ال complement ويكسر لنا ال RBCs اللي + +292 +00:24:40,310 --> 00:24:45,830 +على سطحها antibody فبالتالي هيصير في hemolysis + +293 +00:24:45,830 --> 00:24:51,150 +يبقى ال hemolysis إذا صار معناته الفحص negative + +294 +00:24:51,150 --> 00:24:56,490 +وإذا ماصار معناته الفحص positive يعني في antigen + +295 +00:24:56,490 --> 00:25:00,550 +antibody reaction أو في antibody عند المريض + +296 +00:25:05,550 --> 00:25:10,850 +طبعا بيقدروا بيقيصوا كمية الاربسيز اللي اتكسرت و + +297 +00:25:10,850 --> 00:25:14,210 +هذي proportional to the concentration of antibody + +298 +00:25:14,210 --> 00:25:20,490 +وبهيك بنكون مرينا على مجموعة من الفحوصات اللي + +299 +00:25:20,490 --> 00:25:26,350 +بتمثل اللي هو ال antigen-antibody reaction ك + +300 +00:25:26,350 --> 00:25:30,830 +application وشكرا diff --git a/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/NSVahW18bdQ_raw.json b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/NSVahW18bdQ_raw.json new file mode 100644 index 0000000000000000000000000000000000000000..38b94f7ea92c90168cd7d8da8776b58b95b9137d --- /dev/null +++ b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/NSVahW18bdQ_raw.json @@ -0,0 +1 @@ +{"segments": [{"id": 1, "seek": 2266, "start": 2.26, "end": 22.66, "text": "بسم الله الرحمن الرحيم اليوم ان شاء الله محاضرتنا عن الف حوصات التي تعتمد على ال Antibody reaction و دي محاضرة تقريبا انا بعتبرها محاضرة مراجعة لانه اكيد بعد ما وصلت هالمستوى", "tokens": [3555, 38251, 21984, 34892, 5016, 27842, 34892, 5016, 32640, 45595, 20498, 16472, 13412, 16606, 21984, 3714, 5016, 46958, 43500, 8315, 18871, 27188, 11331, 2407, 9381, 9307, 38392, 6055, 34268, 2304, 3215, 15844, 2423, 5130, 897, 843, 5480, 4032, 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determine the amount of labelled antigen bound to antibody نستخدم اللي هو an H force SO4", "tokens": [37746, 1863, 4587, 1829, 9381, 11296, 8978, 6024, 95, 34740, 9122, 3215, 3224, 49374, 4587, 9381, 2423, 9856, 3714, 33599, 1829, 7251, 30544, 31439, 6225, 3555, 9640, 3660, 18871, 9856, 295, 4537, 6889, 10043, 957, 420, 957, 6545, 286, 6997, 264, 2372, 295, 2715, 41307, 2511, 3213, 5472, 281, 34507, 8717, 14851, 9778, 40448, 13672, 1829, 31439, 364, 389, 3464, 10621, 19], "avg_logprob": -0.4419642894987076, "compression_ratio": 1.3076923076923077, "no_speech_prob": 0.0, "words": [{"start": 965.6, "end": 966.38, "word": "وبنقيصها", "probability": 0.6613972981770834}, {"start": 966.38, "end": 966.48, "word": " في", "probability": 0.75}, {"start": 966.48, "end": 966.98, "word": " الآخر", "probability": 0.8186848958333334}, {"start": 966.98, "end": 967.44, "word": " كده", "probability": 0.5173746744791666}, {"start": 967.44, "end": 968.08, "word": " بينقص", "probability": 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"word": " reaction", "probability": 0.93701171875}, {"start": 1526.17, "end": 1526.35, "word": " ك", "probability": 0.9501953125}, {"start": 1526.35, "end": 1526.89, "word": " application", "probability": 0.892578125}, {"start": 1526.89, "end": 1530.83, "word": " وشكرا", "probability": 0.72802734375}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 1530.96125, "duration_after_vad": 1464.8874999999973} \ No newline at end of file diff --git a/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/PH6whENi6U4.srt b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/PH6whENi6U4.srt new file mode 100644 index 0000000000000000000000000000000000000000..6db7c12feb60384c17ab2138dd44bc0a441959b0 --- /dev/null +++ b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/PH6whENi6U4.srt @@ -0,0 +1,1442 @@ +1 +00:00:01,720 --> 00:00:05,580 +بسم الله الرحمن الرحيم اليوم إن شاء الله هحكي على + +2 +00:00:05,580 --> 00:00:11,820 +الـ antibody structure and function + +3 +00:00:11,820 --> 00:00:15,120 +طبعًا + +4 +00:00:15,120 --> 00:00:21,560 +الـ figure اللي أنتو شايفين إن الـ B cell و الـ T cell can be + +5 +00:00:21,560 --> 00:00:28,580 +activated by any antigen لكن طريقة نشاطهم بتختلف + +6 +00:00:29,720 --> 00:00:34,620 +الـ B cell can recognize الـ antigen directly، any + +7 +00:00:34,620 --> 00:00:38,140 +three-dimensional shape antigen can be recognized + +8 +00:00:38,140 --> 00:00:42,020 +directly by B cell لكن الـ T cell it requires + +9 +00:00:42,020 --> 00:00:48,840 +antigen presentation by antigen presenting cell الـ + +10 +00:00:48,840 --> 00:00:52,720 +lymphocyte activation is triggered by antigen + +11 +00:00:52,720 --> 00:00:56,880 +recognition، كيف تتعرف الـ Antigen recognition is + +12 +00:00:56,880 --> 00:01:00,280 +mediated by a structurally related cell surface + +13 +00:01:00,280 --> 00:01:08,620 +molecule اللي بتعرف عليه الـ cell surface molecule الـ + +14 +00:01:08,620 --> 00:01:14,800 +membrane bound antibody on B lymphocyte و TCR on T + +15 +00:01:14,800 --> 00:01:20,400 +lymphocyte اللي بيتعرف على الـ Antigen هو عبارة عن + +16 +00:01:20,400 --> 00:01:23,840 +الـ structure موجودة على cell membrane of the both + +17 +00:01:23,840 --> 00:01:29,940 +B and T cell في الـ B-cell الـ PCR وفي الـ T-cell الـ + +18 +00:01:29,940 --> 00:01:39,800 +TCR وكما تشاهدون كل خلية محدودة فقط لأحد الـ antigen + +19 +00:01:39,800 --> 00:01:43,360 +وعند + +20 +00:01:43,360 --> 00:01:51,620 +تكوينها هناك بتصير تجارة كلونية كل كلونية لديها مستقبل + +21 +00:01:51,620 --> 00:01:57,140 +مختلف كلهم بيحملوا نفس الـ receptor from all other + +22 +00:01:57,140 --> 00:01:59,440 +receptors which can be distinguished easily طبعًا + +23 +00:01:59,440 --> 00:02:04,620 +من from all other receptors الـ clone تعريفا هو + +24 +00:02:04,620 --> 00:02:08,220 +عبارة عن الـ parental cell حاليا الأمر الـ parental + +25 +00:02:08,220 --> 00:02:14,650 +lymphocytes and all its progeny كل خلفية الـ PCR + +26 +00:02:14,650 --> 00:02:23,910 +هي عبارة عن Cell Surface Antigen Specific + +27 +00:02:23,910 --> 00:02:27,930 +Receptor بيرتبط + +28 +00:02:27,930 --> 00:02:32,230 +عالما بالـ Antigen Extracellular + +29 +00:02:33,140 --> 00:02:39,600 +وتحت بجانب هذا الـ antigen specific receptor في + +30 +00:02:39,600 --> 00:02:46,820 +similar signaling بروتين موجود في both الـ PCR و الـ TCR + +31 +00:02:46,820 --> 00:02:56,960 +يوم يقبض الـ antigen receptor with two or more + +32 +00:02:56,960 --> 00:03:02,260 +antigen يعني شرط أساسي يكون في cross linking الـ + +33 +00:03:04,270 --> 00:03:09,130 +هذه المجموعة من الـ موليكولات الهوائية + +34 +00:03:09,130 --> 00:03:11,010 + +35 +00:03:11,010 --> 00:03:21,970 + + +36 +00:03:22,210 --> 00:03:25,510 +and initiate signal transduction طبعًا بتنتين بتاني + +37 +00:03:25,510 --> 00:03:28,570 +صاروا صار في cross linking بتنتين بيجربوا زي بعض + +38 +00:03:28,570 --> 00:03:32,910 +جان بعض و بيصير في aggregating لـ intracellular و + +39 +00:03:32,910 --> 00:03:40,030 +بيبدأ الـ signal transduction mechanism إلا إذا كان + +40 +00:03:40,030 --> 00:03:46,410 +الـ protein which induce signal transduction is the + +41 +00:03:46,410 --> 00:03:51,690 +same الـ product is all be the same بمعنى الـ بروتين + +42 +00:03:51,690 --> 00:03:58,130 +المنتج سيكون نفسه مرة أخرى إذا كان الـ antigen اللي + +43 +00:03:58,130 --> 00:04:05,310 +عمل الوصول للبروتين + +44 +00:04:05,310 --> 00:04:16,070 +سيكون نفسه نفسه نفسه نفسه نفسه نفسه نفسه نفسه نفسه + +45 +00:04:16,070 --> 00:04:21,110 +نفسه نفسه نفسه نفسه نفسه نفسه نفسهمربعين مربعين + +46 +00:04:21,110 --> 00:04:25,930 +مربعين مربعين مربعين مربعين مربعين مربعين مربعين + +47 +00:04:25,930 --> 00:04:26,250 +مربعين مربعين مربعين مربعين مربعين مربعين مربعين + +48 +00:04:26,250 --> 00:04:27,590 +مرباعين مرباعين مرباعين مرباعين مرباعين مرباعين + +49 +00:04:27,590 --> 00:04:30,050 +مرباعين مرباعين مرباعين مرباعين مرباعين مرباعين + +50 +00:04:30,050 --> 00:04:30,690 +مرباعين مرباعين مرباعين مرباعين مرباعين مرباعين + +51 +00:04:30,690 --> 00:04:30,770 +مرباعين مرباعين مرباعين مرباعين مرباعين مرباعين + +52 +00:04:30,770 --> 00:04:31,310 +مرباعين مرباعين مرباعين مرباعين مرباعين مرباعين + +53 +00:04:31,310 --> 00:04:35,810 +مرباعين مرباعين مرباعين مرباعين مرباعين مرباعين + +54 +00:04:35,810 --> 00:04:42,630 +مرباعين مرباعين مرباعين مرباعين + +55 +00:04:47,650 --> 00:04:50,970 +continue recirculating until it found an antigen + +56 +00:04:50,970 --> 00:04:55,050 +وبرضه بتصير التوشة إذا لاقيت الـ antigen في الـ + +57 +00:04:55,050 --> 00:04:59,530 +secondary lymphoid organs هذا بالنسبة للـ B + +58 +00:04:59,530 --> 00:05:06,990 +lymphocytes بيصير + +59 +00:05:06,990 --> 00:05:09,850 +maturation في الـ bone marrow تطلع على blood + +60 +00:05:09,850 --> 00:05:10,790 +circulation + +61 +00:05:17,060 --> 00:05:21,800 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +62 +00:05:21,800 --> 00:05:22,480 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +63 +00:05:22,480 --> 00:05:24,700 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +64 +00:05:24,700 --> 00:05:26,480 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +65 +00:05:26,480 --> 00:05:28,180 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +66 +00:05:28,180 --> 00:05:32,360 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +67 +00:05:32,360 --> 00:05:37,400 +اللي + +68 +00:05:37,400 --> 00:05:38,000 +اللي + +69 +00:05:40,810 --> 00:05:44,390 +B-cell activation does not require antigen + +70 +00:05:44,390 --> 00:05:48,550 +presentation طب يعني احنا اتفقنا إن جورنا الـ B + +71 +00:05:48,550 --> 00:05:54,670 +-cell عشان تتنشط تترتبط directly بالـ antigen الـ B-cell + +72 +00:05:54,670 --> 00:06:00,010 +are active only against extracellular antigen + +73 +00:06:00,010 --> 00:06:03,670 +بتتعرف على الـ extracellular antigen + +74 +00:06:07,750 --> 00:06:13,670 +أنتو شايفين كل خلية على سطحها Antibody نسميها + +75 +00:06:13,670 --> 00:06:18,270 +Antigen Specific Receptor وهذا الـ Antibody can + +76 +00:06:18,270 --> 00:06:23,550 +recognize one Antigen although sometimes can + +77 +00:06:23,550 --> 00:06:30,930 +recognize different Antigen يعني each B cell بتوج + +78 +00:06:35,120 --> 00:06:43,060 +الخلية النايفة مرتبطة بالممبراين على نييف بي سيل + +79 +00:06:43,060 --> 00:06:48,340 +والنييف بي سيل هي عبارة عن الخلية النايفة التي لم + +80 +00:06:48,340 --> 00:06:53,620 +تواجهها Antigen قبل هيك Antigen plus second signal + +81 +00:06:53,620 --> 00:06:58,960 +stimulate الـ B cell أكتر + +82 +00:06:58,960 --> 00:07:06,070 +الـ B cell بتخلق Antigen into the blood and lymph or + +83 +00:07:06,070 --> 00:07:12,610 +patrolling mucosal surfaces 100% برضه ممكن يقعدوا + +84 +00:07:12,610 --> 00:07:17,570 +على الـ mucosal surfaces هي + +85 +00:07:17,570 --> 00:07:26,650 +ناييف بينفوسايت ارتبطت في Antigen من خلال PCR ونشطت + +86 +00:07:26,650 --> 00:07:33,990 +فبدأت تفرز Antibody نشيء ليه بترتبط بنفس الـ Antigen لإن + +87 +00:07:33,990 --> 00:07:39,030 +ما ننسى إن الـ PCR و الـ secretant antibody both have + +88 +00:07:39,030 --> 00:07:44,250 +the same specificity لإنه هيرتبط بالـ Antigen إيش + +89 +00:07:44,250 --> 00:07:49,990 +specifically اللي نشطها الـ transition from naive + +90 +00:07:49,990 --> 00:07:54,450 +to active cell بي سل بتفرز modified version of B + +91 +00:07:54,450 --> 00:08:02,520 +cell receptor 100% من خلال رحلتها from naive to + +92 +00:08:02,520 --> 00:08:07,300 +active B cell الـ B cell بس تبدأ تتنشط و تفرز هنا + +93 +00:08:07,300 --> 00:08:15,300 +modified version of B cell receptor طبعًا هذا أول B + +94 +00:08:15,300 --> 00:08:19,680 +secret اللي بسموه الـ antibody PCR Uncorresponding + +95 +00:08:19,680 --> 00:08:23,360 +Antibody Share Identical Antispecificity قلت لكوا + +96 +00:08:23,360 --> 00:08:30,880 +لازم نعرف إن الـ Secreted Antibody و الـ PCR اللي قاعد + +97 +00:08:30,880 --> 00:08:37,360 +على سطح الخلية برضه لازم ينهي يعني Have or Share + +98 +00:08:37,360 --> 00:08:44,000 +Identical Specificity What are Antibodies؟ + +99 +00:08:44,000 --> 00:08:48,430 +Antibodies أو بيسموهم immunoglobulin هي نوع من + +100 +00:08:48,430 --> 00:08:49,710 +عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة + +101 +00:08:49,710 --> 00:08:51,290 +عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن + +102 +00:08:51,290 --> 00:08:55,450 +عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة + +103 +00:08:55,450 --> 00:08:58,370 +عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن + +104 +00:08:58,370 --> 00:08:58,990 +عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن + +105 +00:08:58,990 --> 00:08:59,290 +عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن + +106 +00:08:59,290 --> 00:09:09,100 +عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة وهي + +107 +00:09:09,100 --> 00:09:11,640 +الـ Structure of Antibody بالدياكو بس تنتبه على + +108 +00:09:11,640 --> 00:09:15,180 +الصورة الصورة بتقول إن هذه this is a Y-shaped + +109 +00:09:15,180 --> 00:09:19,400 +structure وبيتكون من أربع بولي ببتايد chain + +110 +00:09:19,400 --> 00:09:24,640 +هذا هو two identical light chain و two identical + +111 +00:09:24,640 --> 00:09:30,540 +heavy chain وهي الـ light هذه هي الـ light وهي الـ + +112 +00:09:30,540 --> 00:09:36,080 +heavy شايفين الـ heavy المعلمين بالأسود هدول ماشي؟ + +113 +00:09:37,710 --> 00:09:40,610 +وهي مرتبطة مع بعضها البعض بمعنى الـ disulfide bond + +114 +00:09:40,610 --> 00:09:47,470 +ويكسب المركب الـ Y شبكة الموليكولية. كل شبكة + +115 +00:09:47,470 --> 00:09:49,650 +الإضاءة مرتبطة مع شبكة الهيبوت ومع بعض الـ + +116 +00:09:49,650 --> 00:09:53,170 +disulfide bond وكمان شبكة الهيبوت مرتبطة مع بعض + +117 +00:09:53,170 --> 00:09:55,810 +ببعض الـ disulfide bond يعني ده هم الـ تنتين هم + +118 +00:09:55,810 --> 00:10:00,410 +مرتبطين disulfide و disulfide وهنا برضه في منطقة + +119 +00:10:00,410 --> 00:10:04,550 +عندنا بنسميها hinge region Also bind to each + +120 +00:10:04,550 --> 00:10:11,620 +other ما ننسى إن هناك interchain bond دا هي بترتبط + +121 +00:10:11,620 --> 00:10:15,660 +من الداخل في الـ molecule وبالتالي الـ molecule وبران + +122 +00:10:15,660 --> 00:10:21,380 +molecule متماسك صعب جدًا إنه إيش إنه يعني it's not + +123 +00:10:21,380 --> 00:10:25,740 +it's resistant to degradation it's resistance to + +124 +00:10:25,740 --> 00:10:32,220 +degradation لكن هو بيقطع بواسطة الـ two enzyme الـ + +125 +00:10:32,220 --> 00:10:35,480 +Pepsin والـ Papine وبيحول الـ combination اللي بيصير + +126 +00:10:36,540 --> 00:10:40,000 +antigen binding and effector domain are separated + +127 +00:10:40,000 --> 00:10:45,900 +هذه المنطقة بسموها الـ Fab طبعًا هذه بسموها + +128 +00:10:45,900 --> 00:10:50,320 +antigen binding طيب وين اللي اللي اللي اللي اللي + +129 +00:10:50,320 --> 00:10:52,080 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +130 +00:10:52,080 --> 00:10:53,260 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +131 +00:10:53,260 --> 00:10:53,300 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +132 +00:10:53,300 --> 00:10:53,320 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +133 +00:10:53,320 --> 00:10:56,300 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +134 +00:10:56,300 --> 00:11:04,480 +اللي اللي اللي اللي اللي اللي + +135 +00:11:04,480 --> 00:11:10,550 +اللي اللتحت بسميها الـ Fc portion كل الـ biological + +136 +00:11:10,550 --> 00:11:14,390 +activity الـ antigen بيانديك و تحت فيه الـ biological + +137 +00:11:14,390 --> 00:11:19,570 +activity الـ antigen + +138 +00:11:19,570 --> 00:11:22,470 +ريسبتور هي الـ testing domain زي ما أنتو شايفين كل + +139 +00:11:22,470 --> 00:11:26,130 +globular portion ده هو الـ globular بقى برة الـ + +140 +00:11:26,130 --> 00:11:32,150 +domain ماشي؟ and it's functional domain It's a + +141 +00:11:32,150 --> 00:11:36,270 +functional domain الـ variable ده هي variable + +142 +00:11:36,270 --> 00:11:42,630 +مقصود فيها VH و VL VH ال variable heavy يعني و VL + +143 +00:11:42,630 --> 00:11:47,510 +يعني ال variable light ال V ال variable agent + +144 +00:11:47,510 --> 00:11:52,390 +varies between clone تختلف في اختلاف ال clone وهي + +145 +00:11:52,390 --> 00:11:55,870 +المسؤولة عن ال antigen recognition عشان هيك ال + +146 +00:11:55,870 --> 00:12:01,790 +specificity تحدد من هذه المنطقة وبعد ما أقول لك + +147 +00:12:01,790 --> 00:12:05,290 +تحت هو عبارة عن constant region هو عبارة عن ناشر + +148 +00:12:05,290 --> 00:12:07,350 +constant region وفيه ال effector function ال + +149 +00:12:07,350 --> 00:12:10,710 +biological function زي ما قلت لكم في هذه المناطق + +150 +00:12:10,710 --> 00:12:19,090 +ال body structure or architecture بوجوده + +151 +00:12:19,090 --> 00:12:22,470 +بهذا الشكل يسمح بوجود multiple highly diverse + +152 +00:12:22,470 --> 00:12:27,550 +antigen to induce an identical effector function + +153 +00:12:27,550 --> 00:12:32,530 +شايفين زي ما أنتم شايفين في أن أنتي بتلاتة + +154 +00:12:32,530 --> 00:12:37,310 +antibody الفاب region في كل واحد مختلف وبالتالي كل + +155 +00:12:37,310 --> 00:12:41,750 +واحد هيضطر يتبعيش different antigen لكن ال + +156 +00:12:41,750 --> 00:12:45,210 +constant region واحدة معناته ال antibody في هذا + +157 +00:12:45,210 --> 00:12:51,570 +الحالة واحد لأن ال antibody class يعرف من خلال ال + +158 +00:12:51,570 --> 00:12:54,150 +heavy chain وليس ال dotted chain فال heavy chain + +159 +00:12:54,150 --> 00:13:00,770 +نفسها واحدة يبدأ ال antibody class واحد ماشي فإنه + +160 +00:13:00,770 --> 00:13:05,330 +أن كل antibody class واحد معناته ال signal ال + +161 +00:13:05,330 --> 00:13:10,850 +transduction بتكون إيه واحدة يعني طبعا هو + +162 +00:13:10,850 --> 00:13:15,790 +different variable region ده هي شايفين different + +163 +00:13:15,790 --> 00:13:22,030 +variable region بترتبط ب different antigen لكن + +164 +00:13:22,030 --> 00:13:28,320 +identical constant region ده هي induce identical + +165 +00:13:28,320 --> 00:13:35,020 +response each + +166 +00:13:35,020 --> 00:13:40,380 +light chain contain one variable one constant كل + +167 +00:13:40,380 --> 00:13:47,440 +light chain فيها VL وفيها CL VL و CL and each + +168 +00:13:47,440 --> 00:13:54,700 +heavy chain contain one V هذا هي و + +169 +00:13:56,580 --> 00:14:03,160 +At least تلاتة هذه هي CH واحد CH اتنين CH تلاتة At + +170 +00:14:03,160 --> 00:14:10,280 +least تلاتة ممكن يكون أربع ماشي CH تلاتة constant + +171 +00:14:10,280 --> 00:14:14,720 +domain and + +172 +00:14:14,720 --> 00:14:21,460 +each domain fold وكل domain بي fold بيتشكل يعني + +173 +00:14:21,460 --> 00:14:27,650 +بيفرد ينتقل إلى شكل ثلاثي الأبعاد من الشكل الانتقالي + +174 +00:14:27,650 --> 00:14:35,530 +انتقال إلى شكل ثلاثي الأبعاد من الشكل الانتقالي انتقال + +175 +00:14:35,530 --> 00:14:36,270 +إلى شكل ثلاثي الأبعاد من الشكل الانتقالي انتقال إلى + +176 +00:14:36,270 --> 00:14:36,630 +شكل ثلاثي الأبعاد من الشكل الانتقالي انتقال إلى شكل + +177 +00:14:36,630 --> 00:14:37,650 +ثلاثي الأبعاد من الشكل الانتقالي انتقال إلى شكل + +178 +00:14:37,650 --> 00:14:40,690 +ثلاثي الأبعاد من الشكل الانتقالي انتقال إلى شكل + +179 +00:14:40,690 --> 00:14:42,010 +ثلاثي الأبعاد من الشكل الانتقالي انتقال إلى شكل + +180 +00:14:42,010 --> 00:14:51,710 +ثلاثي الأبعاد من الشكل الانتقالي انتقال إلى + +181 +00:14:51,710 --> 00:14:53,850 +شكل أو عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن + +182 +00:14:53,850 --> 00:14:55,150 +عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة + +183 +00:14:55,150 --> 00:14:57,530 +عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن + +184 +00:14:57,530 --> 00:15:02,270 +عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة + +185 +00:15:02,270 --> 00:15:02,450 +عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن + +186 +00:15:02,450 --> 00:15:03,170 +عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة + +187 +00:15:03,170 --> 00:15:12,830 +عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن + +188 +00:15:12,830 --> 00:15:19,090 +عن عبو الـ Epitope can be recognized on the basis + +189 +00:15:19,090 --> 00:15:24,470 +of sequence or shape طبعا حسب شكله وحسب إيه ال + +190 +00:15:24,470 --> 00:15:29,490 +sequence تبعه ال affinity هي قوة الرابطة ما بين one + +191 +00:15:29,490 --> 00:15:34,330 +fab و one epitope بينما ال avidity هي عبارة عن + +192 +00:15:34,330 --> 00:15:40,830 +مجموع الروابط أو القوة اللي بتتشكل من خلال رابطة + +193 +00:15:42,010 --> 00:15:48,090 +ما بين اثنين لعشرة antigen binding sites لإنه على + +194 +00:15:48,090 --> 00:15:55,790 +سبيل المثال في عندنا ال IGM في خمسة antigen + +195 +00:15:55,790 --> 00:15:56,650 +binding sites + +196 +00:15:59,390 --> 00:16:03,050 +فاليوم اللي بتقعد في الدار هذه ببساطة بتعمل لنا لخمة + +197 +00:16:03,050 --> 00:16:06,590 +في عندها من اثنين لعشرة antigen binding sites + +198 +00:16:06,590 --> 00:16:11,350 +وبالتالي كل antibody ممكن يرتبط من اثنين لعشرة + +199 +00:16:11,350 --> 00:16:16,370 +Epitopes ممكن يرتبط في إيش؟ في من اثنين لعشرة + +200 +00:16:16,370 --> 00:16:23,550 +Epitopes طبعا ال Epitopes ممكن يكونوا identical أو + +201 +00:16:23,550 --> 00:16:27,160 +sufficiently close together على سبيل المثال + +202 +00:16:27,160 --> 00:16:32,080 +Microbial Cell Membrane Surface Protein In this + +203 +00:16:32,080 --> 00:16:37,420 +case, the binding is much greater than affinity + +204 +00:16:37,420 --> 00:16:43,020 +Affinity of what of a single antibody-antigen bond + +205 +00:16:43,020 --> 00:16:49,380 +and it's called avidity. زي ما أنتم شايفين اليوم + +206 +00:16:49,380 --> 00:16:56,160 +يوجد complementary للتاني الابيتوب هو الانتيجم + +207 +00:16:56,160 --> 00:17:00,420 +البروتوب اللي فيه على الشكلية على سطح الانتيبادي + +208 +00:17:00,420 --> 00:17:06,580 +وعلى سطح الانتيجم هذه العيّاب التي تؤثر على + +209 +00:17:06,580 --> 00:17:12,160 +ال antigen recognition جالس من رواحة الانتيبادي + +210 +00:17:12,160 --> 00:17:19,200 +recognize large three or three dimensions طب هيكون + +211 +00:17:19,200 --> 00:17:25,390 +عدد كبير من three dimensions Each clone is specific + +212 +00:17:25,390 --> 00:17:39,970 +for a single antigen Antigen + +213 +00:17:39,970 --> 00:17:43,550 +recognition is mediated by a specific domain اللي + +214 +00:17:43,550 --> 00:17:48,190 +بيمسك في ال antigen specifically هو عبارة عن + +215 +00:17:48,190 --> 00:17:50,010 +specific domain + +216 +00:17:52,340 --> 00:17:59,040 +Signaling Triggered By Cell Activation وكما + +217 +00:17:59,040 --> 00:18:04,620 +تشاهدون هذا مرعن فجر وهو الـ Membrane Bound Cell + +218 +00:18:04,620 --> 00:18:09,440 +Surface Antibody أو البروتين مرتبط بانتجن وهي اللي + +219 +00:18:09,440 --> 00:18:15,720 +بيقولنا الـ immunoglobulin Alpha Beta عملت Signal + +220 +00:18:15,720 --> 00:18:20,740 +Signaling وطلع التأثيرات القاتية طلع ال effector + +221 +00:18:20,740 --> 00:18:26,300 +function يعني ممكن تعمل كمبلمنت فرق فكسيشن و + +222 +00:18:26,300 --> 00:18:32,060 +phagocytic binding طب + +223 +00:18:32,060 --> 00:18:35,680 +نشوف إيش الصفات forms of antigen, macromolecules, + +224 +00:18:36,640 --> 00:18:45,080 +and polysaccharides و نكليك أسد diversity + +225 +00:18:45,080 --> 00:18:51,300 +from conformational changes إبيتوب and linear إبيتوب + +226 +00:18:51,960 --> 00:18:57,640 +Diversity في عشر القوة تسعة Potentially unique + +227 +00:18:57,640 --> 00:19:06,460 +specific Antibody ال Antigen recognition is + +228 +00:19:06,460 --> 00:19:11,760 +mediated by ال variable region والله تتشين هذه ال + +229 +00:19:11,760 --> 00:19:12,020 +region + +230 +00:19:15,020 --> 00:19:18,400 +السيجنالينج بروتيم Alpha-Immunoglobulin Alpha + +231 +00:19:18,400 --> 00:19:21,280 +-Immunoglobulin Beta associated with Membrane + +232 +00:19:21,280 --> 00:19:27,280 +Immunoglobulin البيسيل + +233 +00:19:27,280 --> 00:19:31,140 +يحتاج إلى اكتيفاش طبيعي جدا البيسيل مستقل + +234 +00:19:33,640 --> 00:19:35,980 +T cell dependent and independent + +235 +00:20:09,260 --> 00:20:15,440 +PATHOGEN RECOGNITION RECEPTOR يبقى + +236 +00:20:15,440 --> 00:20:18,580 +هاي ال two signal لازم أول واحدة تمسك وبعدين + +237 +00:20:18,580 --> 00:20:22,680 +الثانية تمسك متى ما مسكت تتنشط ال بي سيل وزي ما + +238 +00:20:22,680 --> 00:20:26,840 +تشوفين هي أتلونت للون الأحمر وصارت active بي سيل + +239 +00:20:26,840 --> 00:20:32,880 +مينجواسيني يعني plasma cell T cell dependent تعتمد + +240 +00:20:32,880 --> 00:20:35,620 +على T cell تعتمد على T lymphocyte تعتمد على T + +241 +00:20:35,620 --> 00:20:40,360 +lymphocyte تعتمد على T lymphocyte تعتمد على T + +242 +00:20:40,360 --> 00:20:43,380 +lymphocyte تعتمد على T lymphocyte تعتمد على T + +243 +00:20:43,380 --> 00:20:43,940 +lymphocyte تعتمد على T lymphocyte تعتمد على T + +244 +00:20:43,940 --> 00:20:46,480 +lymphocyte تعتمد على T lymphocyte تعتمد على T + +245 +00:20:46,480 --> 00:20:50,240 +lymphocyte تعتمد على T lymphocyte تعتمد على T + +246 +00:20:50,240 --> 00:20:58,420 +lymphocyte تعتمد على T lymphocyte تعتمد على T + +247 +00:20:58,420 --> 00:21:06,900 +lymph على سطحها ريسبتور لانتبوكين 2 وعلى سطحها MHC + +248 +00:21:06,900 --> 00:21:11,920 +موليكول 2 اللي عنده القدرة أن يرتبط بالانتجار أخد + +249 +00:21:11,920 --> 00:21:16,180 +الانتجار وعمله processing مين تعرفت عليه هي ال MHC + +250 +00:21:16,180 --> 00:21:24,780 +موليكول وهي اللي إيش ال process طيب + +251 +00:21:24,780 --> 00:21:28,170 +شو يبقى C في هذه الحالة أو الـ Two-Signal في الـ T + +252 +00:21:28,170 --> 00:21:30,470 +-Cell Dependent جالو الـ Two-Signal الأولى مياه + +253 +00:21:30,470 --> 00:21:34,910 +انتجة من خلال الـ PCR والثانية Releasing of + +254 +00:21:34,910 --> 00:21:45,310 +cytokine الثانية إيش؟ Releasing of cytokine الـ + +255 +00:21:45,310 --> 00:21:49,990 +Isotypes جالو فيه خمس أنواع من الـ Hemoglobin من + +256 +00:21:49,990 --> 00:21:58,160 +الـ Heavy Chain اللي بتختلف عن الـ C-Region Each + +257 +00:21:58,160 --> 00:22:03,960 +class is an isotope of a group of individuals. Each + +258 +00:22:03,960 --> 00:22:09,880 +class is an isotope of a group of individuals. Each + +259 +00:22:09,880 --> 00:22:14,260 +isotope يختلف physiologically and biologically + +260 +00:22:14,260 --> 00:22:23,780 +from a defector function. ولو بدنا نحكي عن ال IGE + +261 +00:22:25,630 --> 00:22:29,810 +يعني هو قادر عن Dimer وإن كان فيه إمكانية يكون + +262 +00:22:29,810 --> 00:22:37,770 +Monomer ماشي وفيه إمكانية يكون Dimer ماشي شو اللي + +263 +00:22:37,770 --> 00:22:43,410 +بيعملوا؟ قالوا ده هو موجود على شكل Dimer اللي + +264 +00:22:43,410 --> 00:22:49,010 +ارتبطت ب FC Receptor + +265 +00:22:49,010 --> 00:22:53,830 +شو + +266 +00:22:53,830 --> 00:22:58,510 +بتتم العملية؟ قلنا الـ plasma cell عادة بتصنع أن + +267 +00:22:58,510 --> 00:23:03,370 +IGA IGA محله في الـ mucous membrane فبالتالي بدي + +268 +00:23:03,370 --> 00:23:07,470 +يُخرج ال IGA من ال tissue ويخترق ال cell membrane + +269 +00:23:07,470 --> 00:23:11,850 +اللي هو عبارة عن ال epithelial cells ويطلع برا + +270 +00:23:11,850 --> 00:23:17,630 +على ال mucous membraneكذا بتتم العملية نالو ال + +271 +00:23:17,630 --> 00:23:27,600 +plasma cell secret ال IGA وال IGA ومجرد ما يستدعي + +272 +00:23:27,600 --> 00:23:32,380 +ماشي بروحه مرتبط باتنشط ويرتبط في إيش؟ في الـ + +273 +00:23:32,380 --> 00:23:36,100 +epithelial cells المبطنة لجدار الـ mucous membrane + +274 +00:23:36,100 --> 00:23:40,580 +الداخلي يرتبط ورينجاله يرتبط الـ Receptor بيسموه + +275 +00:23:40,580 --> 00:23:45,440 +poly immunoglobulin وبعدها بيخش في داخل ال tissue + +276 +00:23:45,440 --> 00:23:52,040 +على شكل physical ماشي؟ وال physical ها دي معرضة + +277 +00:23:52,040 --> 00:23:59,030 +لإيش؟ لـ slide اللي هو activation + +278 +00:23:59,030 --> 00:24:05,190 +شو بيحصل فيها جرب يحصل فيه enzymatic degradation + +279 +00:24:05,190 --> 00:24:09,930 +بيطلعوا يكسروا اللي هو ال poly immunoglobulin اللي + +280 +00:24:09,930 --> 00:24:17,010 +أخدنا ناشي ولما تكسروا يطلعوا برا ال physical لكن و + +281 +00:24:17,010 --> 00:24:21,230 +لما نزلنا نطلع لعب نلاقيها ماشية مافيش اللي هو + +282 +00:24:21,230 --> 00:24:26,410 +poly immunoglobulin لكن فيه remnant of it والـ + +283 +00:24:26,410 --> 00:24:33,070 +remnant of it يسموها secretory substance secretory + +284 +00:24:33,070 --> 00:24:36,150 +substance وظيفتها الأساسية أنها تحافظ على + +285 +00:24:36,150 --> 00:24:41,730 +الجزيء from degradation from ايه؟ from + +286 +00:24:41,730 --> 00:24:50,450 +degradation IGD لليوم ال function is unknown لكنه + +287 +00:24:50,450 --> 00:24:56,070 +مستمرا موجود على ال membrane وولا عمره وصلوا + +288 +00:24:56,070 --> 00:25:01,770 +expression on active B cell بيقولوا أن ال IGD + +289 +00:25:01,770 --> 00:25:05,530 +knockout mice don't have any apparent effects يعني + +290 +00:25:05,530 --> 00:25:12,990 +مايله أي significance مايله أيش أي significance بس + +291 +00:25:12,990 --> 00:25:18,170 +بيقولوا أنه أحد الأبحاث أو الدلائل العلمية بتقول + +292 +00:25:18,170 --> 00:25:24,440 +أن ال IGD بالعفو دور كبير في عملية قبل الـ self + +293 +00:25:24,440 --> 00:25:41,420 +-reactive cells أو الجزيئية أو + +294 +00:25:41,420 --> 00:25:41,820 +الجزيئية أو الجزيئية أو الجزيئية أو + +295 +00:25:41,820 --> 00:25:41,900 +الجزيئية أو الجزيئية أو الجزيئية أو + +296 +00:25:41,900 --> 00:25:42,620 +الجزيئية أو الجزيئية أو الجزيئية أو + +297 +00:25:42,620 --> 00:25:47,520 +الجزيئية أو الجزيئية أو الجزيئية أو + +298 +00:25:47,520 --> 00:25:56,170 +الجزيئية أو الـEpsilon Receptor وهذا هو + +299 +00:25:56,170 --> 00:26:00,490 +الإنسان + +300 +00:26:00,490 --> 00:26:07,190 +اللي بدنا نحكي عنه هي جزيء هي جزيء هي + +301 +00:26:07,190 --> 00:26:08,050 +جزيء هي جزيء هي جزيء هي جزيء هي + +302 +00:26:08,050 --> 00:26:08,310 +جزيء هي جزيء هي جزيء هي جزيء هي + +303 +00:26:08,310 --> 00:26:08,910 +جزيء هي جزيء هي جزيء هي جزيء هي + +304 +00:26:08,910 --> 00:26:09,930 +جزيء هي جزيء هي جزيء هي جزيء هي + +305 +00:26:09,930 --> 00:26:12,110 +جزيء هي جزيء هي جزيء هي جزيء هي + +306 +00:26:12,110 --> 00:26:19,170 +جزيء هي جزيء + +307 +00:26:19,170 --> 00:26:25,900 +هيأصبح هناك Degranulation و Activation للخلية لابد + +308 +00:26:25,900 --> 00:26:32,680 +من تنشيط الـ .. الـ + +309 +00:26:32,680 --> 00:26:39,780 +.. ال Complex طيب، أيش اللي بيصير؟ قالوا يوم تتنشط + +310 +00:26:39,780 --> 00:26:43,060 +الخلية من هذا ال Complex، كنا لازم يصير في Cross + +311 +00:26:43,060 --> 00:26:49,300 +-linking بتنشط الخلية وبتطلع لنا حبيبات وقلنا أن + +312 +00:26:49,300 --> 00:26:57,000 +الحبيبات أشهرها الهيستامين والهيبارين وكان يلعب دور + +313 +00:26:57,000 --> 00:27:06,560 +كبير في IGE في قتل ال parasites IGG + +314 +00:27:06,560 --> 00:27:11,960 +ايوا حوالي ست سبعة وظائف قلنا أن أمر واحد + +315 +00:27:14,350 --> 00:27:17,150 +Neutralization Neutralization Neutralization Neutralization + +316 +00:27:17,150 --> 00:27:17,650 +Neutralization Neutralization Neutralization Neutralization + +317 +00:27:17,650 --> 00:27:22,690 +Neutralization Neutralization Neutralization + +318 +00:27:22,690 --> 00:27:27,630 +Neutralization Neutralization Neutralization Neutralization + +319 +00:27:27,630 --> 00:27:28,550 +Neutralization Neutralization Neutralization Neutralization + +320 +00:27:28,550 --> 00:27:36,010 +Neutralization Neutralization Neutralization Neutralization + +321 +00:27:36,010 --> 00:27:43,210 +Neutralization Neutralization + +322 +00:27:45,860 --> 00:27:53,720 +الـ IGG يعمل كـ Opsonizer بعمل Coating للـ + +323 +00:27:53,720 --> 00:28:02,120 +Pathogen ويمنع دخوله إلى الـ Host Cell في + +324 +00:28:02,120 --> 00:28:07,680 +الـ Infectious Pathogen يدخل الـ Host Cell لتشغيله + +325 +00:28:07,680 --> 00:28:10,800 +لما + +326 +00:28:10,800 --> 00:28:15,600 +يدخل الـ pathogen إلى داخل الخلية معناته بده يعمل + +327 +00:28:15,600 --> 00:28:20,520 +propagation pathogen cannot enter cell when coated + +328 +00:28:20,520 --> 00:28:24,660 +with antibody يوم ما هدرت بال cell surface + +329 +00:28:24,660 --> 00:28:28,460 +membrane واتعلم الخلية من برا ما بيصير فيه عملية + +330 +00:28:28,460 --> 00:28:35,540 +إيش يعني + +331 +00:28:35,540 --> 00:28:44,910 +ما بيصيرش عملية اللي هو إيش الـ propagation والـ + +332 +00:28:44,910 --> 00:28:55,270 +killing بهذه الطريقة من برا لبرا أيضا + +333 +00:28:55,270 --> 00:28:58,850 +استكمالا لل IGG زي ما أنتو شايفين IGG + +334 +00:29:03,620 --> 00:29:09,960 +على سطح كل الفجوة ستكسل وهنا مثال على Macrophage + +335 +00:29:09,960 --> 00:29:16,180 +هي مرتبطة بالفجوة الاف سي بورشين once + +336 +00:29:16,180 --> 00:29:24,180 +it binds the antigen بيصير في فجوة سيتوسس بيخش + +337 +00:29:24,180 --> 00:29:30,180 +على شكل Physical بيكون فجوة زوم والفجوة زوم بي + +338 +00:29:31,670 --> 00:29:37,170 +يرتطم بالـ Lysosome بكون فجوة الـ Lysosome والـ + +339 +00:29:37,170 --> 00:29:40,590 +الميكروبيال البيبتايد موجودة على سطح الـ MC Class + +340 +00:29:40,590 --> 00:29:48,190 +II الملكيومي والـ CD4 T Cell Activation وهذه + +341 +00:29:48,190 --> 00:29:52,590 +الطرق التنشيطة طبعا أيضا الـ FC Receptor also + +342 +00:29:52,590 --> 00:29:56,670 +مدينة Antibody مدينة Cell Mediated Cytotoxicity + +343 +00:29:56,670 --> 00:30:06,100 +وهي ال target cell على سطح الـ Multiple Epitope + +344 +00:30:06,100 --> 00:30:11,640 +طبعاً الـ Minoglobulin بيند الـ Antigen على سطح + +345 +00:30:11,640 --> 00:30:18,540 +الـ Target Cell اللي فالت هو الـ Fc Portion وطبعا + +346 +00:30:18,540 --> 00:30:24,100 +الـ Fc Receptor على سطح الـ Natural Killer Cell و + +347 +00:30:24,100 --> 00:30:29,680 +الـ Bind to Fc of Minoglobulin معاقبة الـ Fc + +348 +00:30:29,680 --> 00:30:38,580 +ريسيبتور لجهزة الـ NK لقتل الهدف الهدف + +349 +00:30:38,580 --> 00:30:42,380 +الهدف يموت من الابتعاد الهدف الهدف الهدف الهدف + +350 +00:30:42,380 --> 00:30:49,380 +الهدف الهدف الهدف الهدف الهدف الهدف الهدف الهدف + +351 +00:30:49,380 --> 00:30:49,840 +الهدف الهدف الهدف الهدف الهدف الهدف الهدف الهدف + +352 +00:30:49,840 --> 00:30:50,340 +الهدف الهدف الهدف الهدف الهدف الهدف الهدف الهدف + +353 +00:30:50,340 --> 00:30:54,600 +الهدف الهدف الهدف الهدف الهدف الهدف الهدف ال + +354 +00:30:55,100 --> 00:31:02,220 +زي الـ IGA بـ J-Region J-Region وطبعاً بيعتبر هو + +355 +00:31:02,220 --> 00:31:05,280 +أول Antibody بيخرج لما بتتمشط ال match وبي + +356 +00:31:05,280 --> 00:31:09,620 +lymphocytes important activation of the complement + +357 +00:31:09,620 --> 00:31:20,480 +وكمان له دور كبير في ال after infection و + +358 +00:31:26,900 --> 00:31:32,500 +بنشوفه بكثرة طيب احنا يعني ارجو أن تكونوا قد + +359 +00:31:32,500 --> 00:31:35,040 +استفدتم يكفينا هذه المعلومات عن ال antibody + +360 +00:31:35,040 --> 00:31:38,100 +function and structure + +361 +00:32:43,250 --> 00:32:44,270 +الله أحسنها diff --git a/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/PH6whENi6U4_postprocess.srt b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/PH6whENi6U4_postprocess.srt new file mode 100644 index 0000000000000000000000000000000000000000..d25dbb9dc53f8925ca512dc3445f46e2d4c6c0dc --- /dev/null +++ b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/PH6whENi6U4_postprocess.srt @@ -0,0 +1,1444 @@ +1 +00:00:01,720 --> 00:00:05,580 +بسم الله الرحمن الرحيم اليوم ان شاء الله هحكي على + +2 +00:00:05,580 --> 00:00:11,820 +ال antibody structure and function + +3 +00:00:11,820 --> 00:00:15,120 +طبعا + +4 +00:00:15,120 --> 00:00:21,560 +ال figure اللي انتوا شايفين ان بيسل وتيسل can be + +5 +00:00:21,560 --> 00:00:28,580 +activated by any antigen لكن طريقة نشاطهم بتختلف + +6 +00:00:29,720 --> 00:00:34,620 +الـ B cell can recognize الانتجن directly، any + +7 +00:00:34,620 --> 00:00:38,140 +three-dimensional shape antigen can be recognized + +8 +00:00:38,140 --> 00:00:42,020 +directly by B cell لكن ال T cell it requires + +9 +00:00:42,020 --> 00:00:48,840 +antigen presentation by antigen presenting cell ال + +10 +00:00:48,840 --> 00:00:52,720 +lymphocyte activation is triggered by antigen + +11 +00:00:52,720 --> 00:00:56,880 +recognition، كيف تتعرفالـ Antigen recognition is + +12 +00:00:56,880 --> 00:01:00,280 +mediated by a structurally related cell surface + +13 +00:01:00,280 --> 00:01:08,620 +molecule اللي بتعرف عليه cell surface molecule الـ + +14 +00:01:08,620 --> 00:01:14,800 +membrane bound antibody on B lymphocyte و TCR on T + +15 +00:01:14,800 --> 00:01:20,400 +lymphocyte الجلد يتعرف على الـ Antigen هو عبارة عن + +16 +00:01:20,400 --> 00:01:23,840 +ال structure موجودة على cell membrane of the both + +17 +00:01:23,840 --> 00:01:29,940 +B and T cellفي ال B-cell ال PCR وفي ال T-cell ال + +18 +00:01:29,940 --> 00:01:39,800 +TCR وكما تشاهدون كل خلية محدودة فقط لأحد الانتجين + +19 +00:01:39,800 --> 00:01:43,360 +وعند + +20 +00:01:43,360 --> 00:01:51,620 +اكتبتها هناك اتجارة كلونية كل كلونية لديها مستخدم + +21 +00:01:51,620 --> 00:01:57,140 +مختلف كلهم يحبلوا نفس المستخدمfrom all other + +22 +00:01:57,140 --> 00:01:59,440 +receptors which can be distinguished easily طبعا + +23 +00:01:59,440 --> 00:02:04,620 +من from all other receptors ال clone تعريفا هو + +24 +00:02:04,620 --> 00:02:08,220 +عبارة عن ال parental cell حالية الأمر parental + +25 +00:02:08,220 --> 00:02:14,650 +lymphocytes and all its progeny كل خلفترةالـ PCR + +26 +00:02:14,650 --> 00:02:23,910 +هي عبارة عن Cell Surface Antigen Specific + +27 +00:02:23,910 --> 00:02:27,930 +Receptor بيرتبط + +28 +00:02:27,930 --> 00:02:32,230 +عالما بالـ Antigen Extracellular + +29 +00:02:33,140 --> 00:02:39,600 +وتحت بجانب هذا ال antigen specific receptor في + +30 +00:02:39,600 --> 00:02:46,820 +similar signaling بروتين موجود في both PCR وTCR + +31 +00:02:46,820 --> 00:02:56,960 +يوم يقبض ال antigen receptor with two or more + +32 +00:02:56,960 --> 00:03:02,260 +antigen يعني شرط أساسي كون في cross linking ال + +33 +00:03:04,270 --> 00:03:09,130 +هذه المجموعة من الموليكولات الهوائية الهوائية + +34 +00:03:09,130 --> 00:03:11,010 +الهوائية الهوائية الهوائية الهوائية الهوائية + +35 +00:03:11,010 --> 00:03:21,970 +الهوائية الهوائية الهوائية الهوائية + +36 +00:03:22,210 --> 00:03:25,510 +and initiate signal transduction طبعا بتنتين بتاني + +37 +00:03:25,510 --> 00:03:28,570 +صاروا صار في cross linking بتنتين بيجربوا زي بعض + +38 +00:03:28,570 --> 00:03:32,910 +جان بعض و بيصير في aggregating ل intracellularي و + +39 +00:03:32,910 --> 00:03:40,030 +بيبدأ ال signal transduction mechanism الا اذا كان + +40 +00:03:40,030 --> 00:03:46,410 +ال protein which induce signal transduction is the + +41 +00:03:46,410 --> 00:03:51,690 +same ال product is all be the same بمعنىالبروتين + +42 +00:03:51,690 --> 00:03:58,130 +المتوسط سيكون نفسه مرة أخرى إذا كان الانتجين اللي + +43 +00:03:58,130 --> 00:04:05,310 +عمل الوصول للبروتين + +44 +00:04:05,310 --> 00:04:16,070 +سيكون نفسه نفسه نفسه نفسه نفسه نفسه نفسه نفسه نفسه + +45 +00:04:16,070 --> 00:04:21,110 +نفسه نفسه نفسه نفسه نفسه نفسه نفسهمربعين مربعين + +46 +00:04:21,110 --> 00:04:25,930 +مربعين مربعين مربعين مربعين مربعين مربعين مربعين + +47 +00:04:25,930 --> 00:04:26,250 +مربعين مربعين مربعين مربعين مربعين مربعين مربعين + +48 +00:04:26,250 --> 00:04:27,590 +مرباعين مرباعين مرباعين مرباعين مرباعين مرباعين + +49 +00:04:27,590 --> 00:04:30,050 +مرباعين مرباعين مرباعين مرباعين مرباعين مرباعين + +50 +00:04:30,050 --> 00:04:30,690 +مرباعين مرباعين مرباعين مرباعين مرباعين مرباعين + +51 +00:04:30,690 --> 00:04:30,770 +مرباعين مرباعين مرباعين مرباعين مرباعين مرباعين + +52 +00:04:30,770 --> 00:04:31,310 +مرباعين مرباعين مرباعين مرباعين مرباعين مرباعين + +53 +00:04:31,310 --> 00:04:35,810 +مرباعين مرباعين مرباعين مرباعين مرباعين مرباعين + +54 +00:04:35,810 --> 00:04:42,630 +مرباعين مرباعين مرباعين مرباعين + +55 +00:04:47,650 --> 00:04:50,970 +continue recirculating until it found an antigen + +56 +00:04:50,970 --> 00:04:55,050 +وبرضه بتصير التوشة إذا رجت ال antigen في ال + +57 +00:04:55,050 --> 00:04:59,530 +secondary lymphoid organs هذا بالنسبة لل B + +58 +00:04:59,530 --> 00:05:06,990 +lymphocytes بيصير + +59 +00:05:06,990 --> 00:05:09,850 +maturation في ال bone marrow تطلع على blood + +60 +00:05:09,850 --> 00:05:10,790 +circulation + +61 +00:05:17,060 --> 00:05:21,800 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +62 +00:05:21,800 --> 00:05:22,480 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +63 +00:05:22,480 --> 00:05:24,700 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +64 +00:05:24,700 --> 00:05:26,480 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +65 +00:05:26,480 --> 00:05:28,180 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +66 +00:05:28,180 --> 00:05:32,360 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +67 +00:05:32,360 --> 00:05:37,400 +اللي + +68 +00:05:37,400 --> 00:05:38,000 +اللي + +69 +00:05:40,810 --> 00:05:44,390 +B-cell activation does not require antigen + +70 +00:05:44,390 --> 00:05:48,550 +presentation طب يعني احنا اتفقنا ان جورنا ال B + +71 +00:05:48,550 --> 00:05:54,670 +-cell عشان تتنشط تترتبط directly بالانتيجن B-cell + +72 +00:05:54,670 --> 00:06:00,010 +are active only against extracellular antigen + +73 +00:06:00,010 --> 00:06:03,670 +تتعرف على ال extracellular antigen + +74 +00:06:07,750 --> 00:06:13,670 +أنتوا شايفين كل خلية على سطحها Antibody نسميها + +75 +00:06:13,670 --> 00:06:18,270 +Antigen Specific Receptor وهذا ال Antibody can + +76 +00:06:18,270 --> 00:06:23,550 +recognize one Antigen although sometimes can + +77 +00:06:23,550 --> 00:06:30,930 +recognize different Antigen يعني each pixel توج + +78 +00:06:35,120 --> 00:06:43,060 +الخلية النايفة مرتبطة بالممبراين على نييف بي سيل + +79 +00:06:43,060 --> 00:06:48,340 +والنييف بي سيل هي عبارة عن الخلية نييفة التي لم + +80 +00:06:48,340 --> 00:06:53,620 +تواجهها انتجن قبل هيك انتجن plus second signal + +81 +00:06:53,620 --> 00:06:58,960 +stimulate ال بي سيل اكتر + +82 +00:06:58,960 --> 00:07:06,070 +بي سيل تخلق انتجنinto the blood and lymph or + +83 +00:07:06,070 --> 00:07:12,610 +patrolling mucosal surfaces 100% برضه ممكن يقعدوا + +84 +00:07:12,610 --> 00:07:17,570 +على الـ mucosal surfaces هي + +85 +00:07:17,570 --> 00:07:26,650 +ناييف بينفوسايت ارتبطت في انتجن من خلال PCR ونشطت + +86 +00:07:26,650 --> 00:07:33,990 +فبدت تفرز antibody نشيء ليهبيرتبط بنفس الانتجن لاش + +87 +00:07:33,990 --> 00:07:39,030 +ننسى ان ال PCR و ال secretant antibody both have + +88 +00:07:39,030 --> 00:07:44,250 +the same specificity لإنه هيرتبط بالانتجن ايش + +89 +00:07:44,250 --> 00:07:49,990 +specifically اللي نشطها ال transition from naive + +90 +00:07:49,990 --> 00:07:54,450 +to active cell بي سل secret modified version of B + +91 +00:07:54,450 --> 00:08:02,520 +cell receptor 100%من خلال رحلتها from naive to + +92 +00:08:02,520 --> 00:08:07,300 +active B cell ال B cell بس تبدأ تتنشط و تفرز هنا + +93 +00:08:07,300 --> 00:08:15,300 +modified version of B cell receptor طبعا هذا اول B + +94 +00:08:15,300 --> 00:08:19,680 +secret اللي بسموه ال antibodyPCR Uncorresponding + +95 +00:08:19,680 --> 00:08:23,360 +Antibody Share Identical Antispecificity قلت لكوا + +96 +00:08:23,360 --> 00:08:30,880 +لازم نعرف انه Secreted Antibody و ال PCR اللي قاعد + +97 +00:08:30,880 --> 00:08:37,360 +على السطح الخلية برضه لازم تنهي يعني Have or Share + +98 +00:08:37,360 --> 00:08:44,000 +Identical Specificity What are Antibodies؟ + +99 +00:08:44,000 --> 00:08:48,430 +Antibodies او بيسموهم immunoglobulinهي نوع من + +100 +00:08:48,430 --> 00:08:49,710 +عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة + +101 +00:08:49,710 --> 00:08:51,290 +عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن + +102 +00:08:51,290 --> 00:08:55,450 +عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة + +103 +00:08:55,450 --> 00:08:58,370 +عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن + +104 +00:08:58,370 --> 00:08:58,990 +عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة + +105 +00:08:58,990 --> 00:08:59,290 +عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن + +106 +00:08:59,290 --> 00:09:09,100 +عن عبارة عن عبارة عن عبارة عن عبارة عن عبارةوهي + +107 +00:09:09,100 --> 00:09:11,640 +الـ Structure of Antibody بالدياكو بس تنتبه على + +108 +00:09:11,640 --> 00:09:15,180 +الصورة الصورة بتقول انها this is a Y-shaped + +109 +00:09:15,180 --> 00:09:19,400 +structure وبيتكارى من أربع باري بيبتعد ال chain + +110 +00:09:19,400 --> 00:09:24,640 +هذا هو two identical light chain و two identical + +111 +00:09:24,640 --> 00:09:30,540 +heavy chain وهي ال light هذا هي ال light وهي ال + +112 +00:09:30,540 --> 00:09:36,080 +heavy شايفين ال heavy المعلنين بالأسود هدول ماشي؟ + +113 +00:09:37,710 --> 00:09:40,610 +وهي مرتبطة مع بعضها البعض بمعنى الـ disulfide bond + +114 +00:09:40,610 --> 00:09:47,470 +ويكسب المُركّب الـ Y شبكة الموليكيولية. كل شبكة + +115 +00:09:47,470 --> 00:09:49,650 +الإضاءة مرتبطة مع شبكة الهيبوت ومع بعض الـ + +116 +00:09:49,650 --> 00:09:53,170 +disulfide bond وكمان الشبكة الهيبوت مرتبطة مع بعض + +117 +00:09:53,170 --> 00:09:55,810 +ببعض الـ disulfide bond يعني ده هم التنتين هم + +118 +00:09:55,810 --> 00:10:00,410 +مرتبطين disulfide وdisulfide وهنا برضه في منطقة + +119 +00:10:00,410 --> 00:10:04,550 +عندنا بناسميها English regionAlso bind to each + +120 +00:10:04,550 --> 00:10:11,620 +other ننسى ان هناك انترسالفايت بونده دا هي ترتبط + +121 +00:10:11,620 --> 00:10:15,660 +من الداخل في الميليكيول وبالتالي الميليكيول وبران + +122 +00:10:15,660 --> 00:10:21,380 +ميليكيول متماسك صعب جدا انه ايش انه يعني it's not + +123 +00:10:21,380 --> 00:10:25,740 +it's resistant to degradation it's resistance to + +124 +00:10:25,740 --> 00:10:32,220 +degradation لكن هو بيقطع بواسطة ال two انزايم ال + +125 +00:10:32,220 --> 00:10:35,480 +Pepsin والPapine ويديحول ال combination اللي بيصير + +126 +00:10:36,540 --> 00:10:40,000 +antigen binding and effector domain are separated + +127 +00:10:40,000 --> 00:10:45,900 +هذه المنطقة بيسموها ال fab طبعا هذه بيسموها + +128 +00:10:45,900 --> 00:10:50,320 +antigen binding طيب وين اللي اللي اللي اللي اللي + +129 +00:10:50,320 --> 00:10:52,080 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +130 +00:10:52,080 --> 00:10:53,260 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +131 +00:10:53,260 --> 00:10:53,300 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +132 +00:10:53,300 --> 00:10:53,320 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +133 +00:10:53,320 --> 00:10:56,300 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +134 +00:10:56,300 --> 00:11:04,480 +اللي اللي اللي اللي اللي اللي + +135 +00:11:04,480 --> 00:11:10,550 +اللي اللتحت تسميها الـ Fc portion كل ال biological + +136 +00:11:10,550 --> 00:11:14,390 +activity انتجن بيانديك و تحت فيه biological + +137 +00:11:14,390 --> 00:11:19,570 +activity الانتجن + +138 +00:11:19,570 --> 00:11:22,470 +ريسبتور هي ال testing domain زي ما انتوا شايفين كل + +139 +00:11:22,470 --> 00:11:26,130 +globular portion ده هو ال globular بقى بره ال + +140 +00:11:26,130 --> 00:11:32,150 +domain ماشي؟ and it's functional domainIt's a + +141 +00:11:32,150 --> 00:11:36,270 +functional domain الـ variable ده هي variable + +142 +00:11:36,270 --> 00:11:42,630 +مقصود فيها VH و VL VH ال variable heavy يعني و VL + +143 +00:11:42,630 --> 00:11:47,510 +يعني ال variable light ال V ال variable agent + +144 +00:11:47,510 --> 00:11:52,390 +varies between clone تختلف في اختلاف ال clone وهي + +145 +00:11:52,390 --> 00:11:55,870 +المسؤولة عن ال antigen recognition عشان هيك ال + +146 +00:11:55,870 --> 00:12:01,790 +specificity تحدد من هذه المنطقة وبعد ما أقولانت + +147 +00:12:01,790 --> 00:12:05,290 +تحت هو عبارة عن constant region هو عبارة عن ناشر + +148 +00:12:05,290 --> 00:12:07,350 +constant region وفيه ال effector function ال + +149 +00:12:07,350 --> 00:12:10,710 +biological function زي ما قلت لكوا في هذه المناطق + +150 +00:12:10,710 --> 00:12:19,090 +ال body structure or architecture بوجوده + +151 +00:12:19,090 --> 00:12:22,470 +بهذا الشكل يسمح بوجود multiple highly diverse + +152 +00:12:22,470 --> 00:12:27,550 +antigen to induce an identical effector function + +153 +00:12:27,550 --> 00:12:32,530 +شايفين زي ما انتوا شايفينفي أن أنتي بتلاتة + +154 +00:12:32,530 --> 00:12:37,310 +antibody الفاب region في كل واحد مختلف وبالتالي كل + +155 +00:12:37,310 --> 00:12:41,750 +واحد هيضطر يتبعيش different antigen لكن ال + +156 +00:12:41,750 --> 00:12:45,210 +constant region واحدة معناته ال antibody في هذا + +157 +00:12:45,210 --> 00:12:51,570 +الحالة واحد لأن ال antibody class يعرف من خلال ال + +158 +00:12:51,570 --> 00:12:54,150 +hybrid chain وليس ال dotted chain فالhybrid chain + +159 +00:12:54,150 --> 00:13:00,770 +نفسها واحدة يبدأ ال antibody class واحدماشي فانه + +160 +00:13:00,770 --> 00:13:05,330 +ان كل antibody class واحد معناته ال signal ال + +161 +00:13:05,330 --> 00:13:10,850 +transduction بتكون ايه اش واحدة يعني طبعا هو + +162 +00:13:10,850 --> 00:13:15,790 +different variable region ده هي شايفين different + +163 +00:13:15,790 --> 00:13:22,030 +variable region بترتبط ب different antigen لكن + +164 +00:13:22,030 --> 00:13:28,320 +identical constant region ده هيinduce identical + +165 +00:13:28,320 --> 00:13:35,020 +response each + +166 +00:13:35,020 --> 00:13:40,380 +lighted chain contain one variable one constant كل + +167 +00:13:40,380 --> 00:13:47,440 +lighted chain فيها و VL و فيها CL VL و CL and each + +168 +00:13:47,440 --> 00:13:54,700 +heavy chain contain one V هذا هي و + +169 +00:13:56,580 --> 00:14:03,160 +At least تلاتة هذه هي CH واحد CH اتنين CH تلاتة At + +170 +00:14:03,160 --> 00:14:10,280 +least تلاتة ممكن يكون اربع ماشي CH تلاتة constant + +171 +00:14:10,280 --> 00:14:14,720 +domain and + +172 +00:14:14,720 --> 00:14:21,460 +each domain fold وكل domain بي fold بيتشكل يعني + +173 +00:14:21,460 --> 00:14:27,650 +بيفردانتقل الى شكل ثلاثمائية من الشكل الانتقالي + +174 +00:14:27,650 --> 00:14:35,530 +انتقال الى شكل ثلاثمائية من الشكل الانتقالي انتقال + +175 +00:14:35,530 --> 00:14:36,270 +الى شكل ثلاثمائية من الشكل الانتقالي انتقال الى + +176 +00:14:36,270 --> 00:14:36,630 +شكل ثلاثمائية من الشكل الانتقالي انتقال الى شكل + +177 +00:14:36,630 --> 00:14:37,650 +ثلاثمائية من الشكل الانتقالي انتقال الى شكل + +178 +00:14:37,650 --> 00:14:40,690 +ثلاثمائية من الشكل الانتقالي انتقال الى شكل + +179 +00:14:40,690 --> 00:14:42,010 +ثلاثمائية من الشكل الانتقالي انتقال الى شكل + +180 +00:14:42,010 --> 00:14:51,710 +ثلاثمائية من الشكل الانتقالي انتقال الى + +181 +00:14:51,710 --> 00:14:53,850 +شكلأو عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن + +182 +00:14:53,850 --> 00:14:55,150 +عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة + +183 +00:14:55,150 --> 00:14:57,530 +عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن + +184 +00:14:57,530 --> 00:15:02,270 +عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة + +185 +00:15:02,270 --> 00:15:02,450 +عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن + +186 +00:15:02,450 --> 00:15:03,170 +عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة + +187 +00:15:03,170 --> 00:15:12,830 +عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة + +188 +00:15:12,830 --> 00:15:19,090 +عن عبوالـ Epitope can be recognized on the basis + +189 +00:15:19,090 --> 00:15:24,470 +of sequence or shape طبعا حسب شكله وحسب إيه ال + +190 +00:15:24,470 --> 00:15:29,490 +sequence تبعه ال affinity هي قوة الرابط ما بين one + +191 +00:15:29,490 --> 00:15:34,330 +fab و one epitope بينما ال avidity هي عبارة عن + +192 +00:15:34,330 --> 00:15:40,830 +مجموع الروابط أو القوة اللي بتتشكل من خلال رابط + +193 +00:15:42,010 --> 00:15:48,090 +مابين اتنين لعشرة antigen binding sites لإنه على + +194 +00:15:48,090 --> 00:15:55,790 +سبيل المثال في عندنا ال IGM في خمسة antigen + +195 +00:15:55,790 --> 00:15:56,650 +binding sites + +196 +00:15:59,390 --> 00:16:03,050 +فاليوم اللي بتقعد في الدار هذه ببساطة بتعملنا لخمة + +197 +00:16:03,050 --> 00:16:06,590 +في عندها من اتنين لعشرة antigen binding sites + +198 +00:16:06,590 --> 00:16:11,350 +وبالتالي كل antibody ممكن يرتبط من اتنين لعشرة + +199 +00:16:11,350 --> 00:16:16,370 +Epitopes ممكن يرتبط في ايش؟ في من اتنين لعشرة + +200 +00:16:16,370 --> 00:16:23,550 +Epitopes طبعا ال Epitopes ممكن يكونوا identical أو + +201 +00:16:23,550 --> 00:16:27,160 +sufficiently close togetherعلى سبيل المثال + +202 +00:16:27,160 --> 00:16:32,080 +Microbial Cell Membrane Surface Protein In this + +203 +00:16:32,080 --> 00:16:37,420 +case, the binding is much greater than affinity + +204 +00:16:37,420 --> 00:16:43,020 +Affinity of what of a single antibody-antigen bond + +205 +00:16:43,020 --> 00:16:49,380 +and it's called avidity.زي ما انتوا شايفين اليوم + +206 +00:16:49,380 --> 00:16:56,160 +يوعد complementary للتاني الابيتوبهو الانتيجم + +207 +00:16:56,160 --> 00:17:00,420 +البراتوب اللي فيه على الشكلية على سطح الانتيبادي + +208 +00:17:00,420 --> 00:17:06,580 +وعلى سطح الانتيجم هذه العياب التي تؤثر على + +209 +00:17:06,580 --> 00:17:12,160 +الانتيجم recognition جالس من رواحة الانتيبادي + +210 +00:17:12,160 --> 00:17:19,200 +recognize large three or three dimensions طب هيكون + +211 +00:17:19,200 --> 00:17:25,390 +عدد كبير من three dimensionsEach clone is specific + +212 +00:17:25,390 --> 00:17:39,970 +for a single antigen Antigen + +213 +00:17:39,970 --> 00:17:43,550 +recognition is mediated by a specific domain اللي + +214 +00:17:43,550 --> 00:17:48,190 +بيمسك في الantigen specifically هو عبارة عن + +215 +00:17:48,190 --> 00:17:50,010 +specific domain + +216 +00:17:52,340 --> 00:17:59,040 +Signaling Triggered By Cell Activation وكما + +217 +00:17:59,040 --> 00:18:04,620 +تشاهدون هذا مرعن فجر وهو الـ Membrane Bound Cell + +218 +00:18:04,620 --> 00:18:09,440 +Surface Antibody أو البروتين مرتبط بانتجن وهي اللي + +219 +00:18:09,440 --> 00:18:15,720 +بيقولنا الـ immunoglobulin Alpha Beta عملت Signal + +220 +00:18:15,720 --> 00:18:20,740 +Signaling وطلع التأثيرات القاتية طلع ال effector + +221 +00:18:20,740 --> 00:18:26,300 +function يعنيبممكن تعمل كمبلمنت فرق فكسيشن و + +222 +00:18:26,300 --> 00:18:32,060 +phagocystic binding طب + +223 +00:18:32,060 --> 00:18:35,680 +نشوف إيش الصفات forms of antigen, macromolecules, + +224 +00:18:36,640 --> 00:18:45,080 +and polysaccharides و نكليك أسد diversity + +225 +00:18:45,080 --> 00:18:51,300 +from conformational changes ابتوب and linear ابتوب + +226 +00:18:51,960 --> 00:18:57,640 +Diversity في عشر القوة تسعة Potentially unique + +227 +00:18:57,640 --> 00:19:06,460 +specific Antibody ال Antigen recognition is + +228 +00:19:06,460 --> 00:19:11,760 +mediated by ال variable region والله تتشين هذه ال + +229 +00:19:11,760 --> 00:19:12,020 +region + +230 +00:19:15,020 --> 00:19:18,400 +السيجنالينج بروتيم Alpha-Aminoglobulin Alpha + +231 +00:19:18,400 --> 00:19:21,280 +-Aminoglobulin Beta associated with Membrane + +232 +00:19:21,280 --> 00:19:27,280 +Aminoglobulin البيسيل + +233 +00:19:27,280 --> 00:19:31,140 +يحتاج إلى اكتيفاش طبيعي جدا البيسيل مستقل + +234 +00:19:33,640 --> 00:19:35,980 +تسل ديبندنت اندبندنسري + +235 +00:20:09,260 --> 00:20:15,440 +PATHOGEN RECOGNITION RECEPTOR يبقى + +236 +00:20:15,440 --> 00:20:18,580 +هاي ال two signal لازم أول واحدة تمسك وبعدين + +237 +00:20:18,580 --> 00:20:22,680 +التانية تمسك متى ما مسكت تتنشط ال بي سيل وزي ما + +238 +00:20:22,680 --> 00:20:26,840 +تشوفين هي أتلونت للون الأحمر وصارت active بي سيل + +239 +00:20:26,840 --> 00:20:32,880 +مينجواسيني يعني plasma cellT cell dependent تعتمد + +240 +00:20:32,880 --> 00:20:35,620 +على T cell تعتمد على T lymphocyte تعتمد على T + +241 +00:20:35,620 --> 00:20:40,360 +lymphocyte تعتمد على T lymphocyte تعتمد على T + +242 +00:20:40,360 --> 00:20:43,380 +lymphocyte تعتمد على T lymphocyte تعتمد على T + +243 +00:20:43,380 --> 00:20:43,940 +lymphocyte تعتمد على T lymphocyte تعتمد على T + +244 +00:20:43,940 --> 00:20:46,480 +lymphocyte تعتمد على T lymphocyte تعتمد على T + +245 +00:20:46,480 --> 00:20:50,240 +lymphocyte تعتمد على T lymphocyte تعتمد على T + +246 +00:20:50,240 --> 00:20:58,420 +lymphocyte تعتمد على T lymphocyte تعتمد على T + +247 +00:20:58,420 --> 00:21:06,900 +lymphعلى سطحها ريسيبتور لانتبوكين 2 وعلى سطحها Mhc + +248 +00:21:06,900 --> 00:21:11,920 +موليكول 2 اللي عنده القدرة ان يرتبط بالانتجار اخد + +249 +00:21:11,920 --> 00:21:16,180 +الانتجار وعمله processing مين تعرفت عليه هى ال Mhc + +250 +00:21:16,180 --> 00:21:24,780 +موليكول وهى اللي ايه اش ال process طيب + +251 +00:21:24,780 --> 00:21:28,170 +شو يبقى C في هذه الحالةأو الـ Two-Signal في الـ T + +252 +00:21:28,170 --> 00:21:30,470 +-Cell Dependent جالو الـ Two-Signal الأولى مياه + +253 +00:21:30,470 --> 00:21:34,910 +انتجة من خلال الـ PCR والتانية Releasing of + +254 +00:21:34,910 --> 00:21:45,310 +cytokine التانية إيش؟ Releasing of cytokine الـ + +255 +00:21:45,310 --> 00:21:49,990 +Isotypes جالو فيه خمس أنواع من الـ Hemoglobin من + +256 +00:21:49,990 --> 00:21:58,160 +الـ Heavy Chain اللي بتختلف عن الـ C-RegionEach + +257 +00:21:58,160 --> 00:22:03,960 +class is an isotope of a group of individuals.Each + +258 +00:22:03,960 --> 00:22:09,880 +class is an isotope of a group of individuals.Each + +259 +00:22:09,880 --> 00:22:14,260 +isotope يختلف physiologically and biologically + +260 +00:22:14,260 --> 00:22:23,780 +from a defector function.ولو بدنا نحكي عن ال IGE + +261 +00:22:25,630 --> 00:22:29,810 +يعني هو قدر عن Diamer وإن كان فيه إمكانية يكون + +262 +00:22:29,810 --> 00:22:37,770 +Monomer ماشي وفيه إمكانية يكون Diamer ماشي شو اللي + +263 +00:22:37,770 --> 00:22:43,410 +بيعملوا؟ قالوا ده هو موجود على شكل Diamer اللي + +264 +00:22:43,410 --> 00:22:49,010 +ارتبطت ب FC Porsche + +265 +00:22:49,010 --> 00:22:53,830 +شو + +266 +00:22:53,830 --> 00:22:58,510 +بتتم العملية؟ قلناالـ plasma cell عادة بتصنع ان + +267 +00:22:58,510 --> 00:23:03,370 +IGA IGA محله في الـ mucous membrane فبالتالي بدي + +268 +00:23:03,370 --> 00:23:07,470 +يطلع ال IGA من ال tissue و يخترق ال cell membrane + +269 +00:23:07,470 --> 00:23:11,850 +اللي هو عبارة عن ال epithelial cells و يطلع برا + +270 +00:23:11,850 --> 00:23:17,630 +على ال mucous membrane كذا بالتم العملية نالو ال + +271 +00:23:17,630 --> 00:23:27,600 +plasma cell secret ال IGA و ال IGAو مجرد ما يستدعى + +272 +00:23:27,600 --> 00:23:32,380 +ماشي بروحه مرتبط باتنشط و برتبط في إيش؟ في الـ + +273 +00:23:32,380 --> 00:23:36,100 +epithelial cells المبطنة لجدار الـ mucous membrane + +274 +00:23:36,100 --> 00:23:40,580 +الداخلي برتبط ورينجاله برتبط الـ preceptor بيسموه + +275 +00:23:40,580 --> 00:23:45,440 +poly immunoglobulin و بعدها بيخش في داخل ال tissue + +276 +00:23:45,440 --> 00:23:52,040 +على شكل physical ماشي؟ و ال physical ها دي معرضة + +277 +00:23:52,040 --> 00:23:59,030 +لإيش؟ ل slideاللي هو activation + +278 +00:23:59,030 --> 00:24:05,190 +شو بيحصل فيها جرب يحصل فيه enzymatic degradation + +279 +00:24:05,190 --> 00:24:09,930 +بيطلعوا يكسروا اللي هو ال poly immunoglobulin اللي + +280 +00:24:09,930 --> 00:24:17,010 +أخدنا ناشي و لما تكسروا تطلع برا ال physical لكن و + +281 +00:24:17,010 --> 00:24:21,230 +لما نزلنا نطلع لعب نلاقيها ماشي مافيشش اللي هو + +282 +00:24:21,230 --> 00:24:26,410 +poly immunoglobulin لكن فيه remnantof it و الـ + +283 +00:24:26,410 --> 00:24:33,070 +remnant of it يسموها secretory substance secretory + +284 +00:24:33,070 --> 00:24:36,150 +substance وظيفتها الأساسية انها تحافظ على + +285 +00:24:36,150 --> 00:24:41,730 +الموليكيور from degradation from ايه؟ from + +286 +00:24:41,730 --> 00:24:50,450 +degradation IGD لليوم ال function is unknown لكنه + +287 +00:24:50,450 --> 00:24:56,070 +مستمرا موجود على ال membraneوولا عمره وصلوا + +288 +00:24:56,070 --> 00:25:01,770 +expression on active B cell بيقولوا ان ال IGD + +289 +00:25:01,770 --> 00:25:05,530 +knockout mice don't have any apparent effects يعني + +290 +00:25:05,530 --> 00:25:12,990 +مايله أي significance مايله أيش أي significance بس + +291 +00:25:12,990 --> 00:25:18,170 +بيقولوا انه احد الأبحاث أو الدلائل العلمية بتقول + +292 +00:25:18,170 --> 00:25:24,440 +ان ال IGD بالعفو دوري كبير فيعملية قبل الـ self + +293 +00:25:24,440 --> 00:25:41,420 +-reactive cells او الموليكولوجيا او + +294 +00:25:41,420 --> 00:25:41,820 +الموليكولوجيا او الموليكولوجيا او الموليكولوجيا او + +295 +00:25:41,820 --> 00:25:41,900 +الموليكولوجيا او الموليكولوجيا او الموليكولوجيا او + +296 +00:25:41,900 --> 00:25:42,620 +الموليكولوجيا او الموليكولوجيا او الموليكولوجيا او + +297 +00:25:42,620 --> 00:25:47,520 +الموليكولوجيا او الموليكولوجيا او الموليكولوجيا او + +298 +00:25:47,520 --> 00:25:56,170 +الموليكولوجيا او الموليأبسلون ريسبتور وهذا هو + +299 +00:25:56,170 --> 00:26:00,490 +الانسان + +300 +00:26:00,490 --> 00:26:07,190 +اللي بدنا نحكي عنه هي موليكيول هي موليكيول هي + +301 +00:26:07,190 --> 00:26:08,050 +موليكيول هي موليكيول هي موليكيول هي موليكيول هي + +302 +00:26:08,050 --> 00:26:08,310 +موليكيول هي موليكيول هي موليكيول هي موليكيول هي + +303 +00:26:08,310 --> 00:26:08,910 +موليكيول هي موليكيول هي موليكيول هي موليكيول هي + +304 +00:26:08,910 --> 00:26:09,930 +موليكيول هي موليكيول هي موليكيول هي موليكيول هي + +305 +00:26:09,930 --> 00:26:12,110 +موليكيول هي موليكيول هي موليكيول هي موليكيول هي + +306 +00:26:12,110 --> 00:26:19,170 +موليكيول هي موليكيول + +307 +00:26:19,170 --> 00:26:25,900 +هيأصبح هناك Degranulation و Activation للخلية لابد + +308 +00:26:25,900 --> 00:26:32,680 +من تنشيط ال .. ال + +309 +00:26:32,680 --> 00:26:39,780 +.. ال Complex طيب، أيش اللي بصير؟ جالوا يوم تتنشط + +310 +00:26:39,780 --> 00:26:43,060 +الخلية من هذا ال Complex، كنا لازم يصير في Cross + +311 +00:26:43,060 --> 00:26:49,300 +-linkingبتنشط الخلية وبتطلع لنا جرانيوز وقلنا ان + +312 +00:26:49,300 --> 00:26:57,000 +جرانيوز أشهرها الهستامين والهيبرين وكان يلعب دور + +313 +00:26:57,000 --> 00:27:06,560 +كبير في IGE في قتل ال parasites IGG + +314 +00:27:06,560 --> 00:27:11,960 +ايوة حوالي ست سبعة وظائف قلنا ان امر واحد + +315 +00:27:14,350 --> 00:27:17,150 +نتراليزيشن نتراليزيشن نتراليزيشن نتراليزيشن + +316 +00:27:17,150 --> 00:27:17,650 +نتراليزيشن نتراليزيشن نتراليزيشن نتراليزيشن + +317 +00:27:17,650 --> 00:27:22,690 +نتراليزيشن نتراليزيشن نتراليزيشن + +318 +00:27:22,690 --> 00:27:27,630 +نتراليزيشن نتراليزيشن نتراليزيشن نتراليزيشن + +319 +00:27:27,630 --> 00:27:28,550 +نتراليزيشن نتراليزيشن نتراليزيشن نتراليزيشن + +320 +00:27:28,550 --> 00:27:36,010 +نتراليزيشن نتراليزيشن نتراليزيشن نتراليزيشن + +321 +00:27:36,010 --> 00:27:43,210 +نتراليزيشن نتراليزيش + +322 +00:27:45,860 --> 00:27:53,720 +الـ IGG يعمل كـ Obscenizer بعمل Coating للـ + +323 +00:27:53,720 --> 00:28:02,120 +Pathogen ويمنع دخوله إلى الـ Host Cell في + +324 +00:28:02,120 --> 00:28:07,680 +الـ Infectious Pathogen يدخل الـ Host Cell لتشغيله + +325 +00:28:07,680 --> 00:28:10,800 +لما + +326 +00:28:10,800 --> 00:28:15,600 +يدخلالـ pathogen إلى داخل الخلية معناته بده يعمل + +327 +00:28:15,600 --> 00:28:20,520 +propagation pathogen cannot enter cell when coated + +328 +00:28:20,520 --> 00:28:24,660 +with antibody يوم ما هدرت بال cell surface + +329 +00:28:24,660 --> 00:28:28,460 +membrane واتعلم الخلية من برا ما بيصير فيه عملية + +330 +00:28:28,460 --> 00:28:35,540 +إيش يعني + +331 +00:28:35,540 --> 00:28:44,910 +ما بيصيرش عملية اللي هو إيشالـ propagation و ال + +332 +00:28:44,910 --> 00:28:55,270 +killing بهذه الطريقة من برا لبرا ايضا + +333 +00:28:55,270 --> 00:28:58,850 +استكمالا لل IGG زى ما انتوا شايفين IGG + +334 +00:29:03,620 --> 00:29:09,960 +على سطح كل الفاجوة ستكسل وهنا مثال على Macrophage + +335 +00:29:09,960 --> 00:29:16,180 +هي مرتبطة بالفاجوة الاف سي بورشين once + +336 +00:29:16,180 --> 00:29:24,180 +it binds the antigen بيصير في فاجوه سيتوسس بيخش + +337 +00:29:24,180 --> 00:29:30,180 +على شكل physical بيكون فاجوه زوم و الفاجوه زوم بي + +338 +00:29:31,670 --> 00:29:37,170 +يرتطم بالـ Lysosome بكون فاجو الـ Lysosome و + +339 +00:29:37,170 --> 00:29:40,590 +الميكروبيل البيبتايد موجودة على سطح الـ MC Class + +340 +00:29:40,590 --> 00:29:48,190 +II الملكيومي و الـ CD4 T Cell Activation و هذه + +341 +00:29:48,190 --> 00:29:52,590 +الطرق التنشيطة طبعا أيضا الـ FC Receptor also + +342 +00:29:52,590 --> 00:29:56,670 +مدينة Antibody مدينة Cell Mediated Cytotoxicity + +343 +00:29:56,670 --> 00:30:06,100 +وهي ال target cellعلى سطح الـ Multiple Epitope + +344 +00:30:06,100 --> 00:30:11,640 +طبعاً الـ Minoglobulin بيند الـ Antigen على سطح + +345 +00:30:11,640 --> 00:30:18,540 +الـ Target Cell اللي فالت هو الـ Fc Portion وطبعا + +346 +00:30:18,540 --> 00:30:24,100 +الـ Fc Receptor على سطح الـ Natural Killer Cell و + +347 +00:30:24,100 --> 00:30:29,680 +الـ Bind to Fc of Minoglobulinمعاقبة الـ Fc + +348 +00:30:29,680 --> 00:30:38,580 +ريسيبتور لجهزة الـ NK لقتل الهدف الهدف + +349 +00:30:38,580 --> 00:30:42,380 +الهدف يموت من الابتعاد الهدف الهدف الهدف الهدف + +350 +00:30:42,380 --> 00:30:49,380 +الهدف الهدف الهدف الهدف الهدف الهدف الهدف الهدف + +351 +00:30:49,380 --> 00:30:49,840 +الهدف الهدف الهدف الهدف الهدف الهدف الهدف الهدف + +352 +00:30:49,840 --> 00:30:50,340 +الهدف الهدف الهدف الهدف الهدف الهدف الهدف الهدف + +353 +00:30:50,340 --> 00:30:54,600 +الهدف الهدف الهدف الهدف الهدف الهدف الهدف اله + +354 +00:30:55,100 --> 00:31:02,220 +زي الـ IGA بـ J-Region J-Region وطبعاً بيعتبر هو + +355 +00:31:02,220 --> 00:31:05,280 +أول antibody بيخرجش لما بتتمشط ال match و بي + +356 +00:31:05,280 --> 00:31:09,620 +lymphocytes important activation of the complement + +357 +00:31:09,620 --> 00:31:20,480 +وكمان له دور كبير في ال after infection و + +358 +00:31:26,900 --> 00:31:32,500 +بنشوفه بكثرة طيب احنا يعني ارجو ان تكونوا قد + +359 +00:31:32,500 --> 00:31:35,040 +استفدتم يكفينا هذه المعلومات عن ال antibody + +360 +00:31:35,040 --> 00:31:38,100 +function and structure + +361 +00:32:43,250 --> 00:32:44,270 +الله أحسنها + diff --git a/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/PH6whENi6U4_raw.json b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/PH6whENi6U4_raw.json new file mode 100644 index 0000000000000000000000000000000000000000..f14c6bcd519cd5a4c4c6dc0df201b72690efaec9 --- /dev/null +++ b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/PH6whENi6U4_raw.json @@ -0,0 +1 @@ +{"segments": [{"id": 1, "seek": 2858, "start": 1.72, "end": 28.58, "text": "بسم الله الرحمن الرحيم اليوم ان شاء الله هحكي على ال antibody structure and function طبعا ال figure اللي انتوا شايفين ان بيسل وتيسل can be activated by any antigen لكن طريقة نشاطهم بتختلف", "tokens": [3555, 38251, 21984, 34892, 5016, 27842, 34892, 5016, 32640, 45595, 20498, 16472, 13412, 16606, 21984, 8032, 5016, 4117, 1829, 15844, 2423, 34507, 3877, 293, 2445, 23032, 3555, 3615, 995, 2423, 2573, 13672, 1829, 16472, 2655, 14407, 13412, 995, 33911, 9957, 16472, 4724, 1829, 3794, 1211, 4032, 31371, 3794, 1211, 393, 312, 18157, 538, 604, 2511, 3213, 44381, 23032, 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100644 index 0000000000000000000000000000000000000000..0b6b15acebe184d99fa684cdf49e70ee28f649d4 --- /dev/null +++ b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/PH6whENi6U4_raw.srt @@ -0,0 +1,1528 @@ +1 +00:00:01,720 --> 00:00:05,580 +بسم الله الرحمن الرحيم اليوم ان شاء الله هحكي على + +2 +00:00:05,580 --> 00:00:11,820 +ال antibody structure and function + +3 +00:00:11,820 --> 00:00:15,120 +طبعا + +4 +00:00:15,120 --> 00:00:21,560 +ال figure اللي انتوا شايفين ان بيسل وتيسل can be + +5 +00:00:21,560 --> 00:00:28,580 +activated by any antigen لكن طريقة نشاطهم بتختلف + +6 +00:00:29,720 --> 00:00:34,620 +الـ B cell can recognize الانتجن directly، any + +7 +00:00:34,620 --> 00:00:38,140 +three-dimensional shape antigen can be recognized + +8 +00:00:38,140 --> 00:00:42,020 +directly by B cell لكن ال T cell it requires + +9 +00:00:42,020 --> 00:00:48,840 +antigen presentation by antigen presenting cell ال + +10 +00:00:48,840 --> 00:00:52,720 +lymphocyte activation is triggered by antigen + +11 +00:00:52,720 --> 00:00:56,880 +recognition، كيف تتعرفالـ Antigen recognition is + +12 +00:00:56,880 --> 00:01:00,280 +mediated by a structurally related cell surface + +13 +00:01:00,280 --> 00:01:08,620 +molecule اللي بتعرف عليه cell surface molecule الـ + +14 +00:01:08,620 --> 00:01:14,800 +membrane bound antibody on B lymphocyte و TCR on T + +15 +00:01:14,800 --> 00:01:20,400 +lymphocyte الجلد يتعرف على الـ Antigen هو عبارة عن + +16 +00:01:20,400 --> 00:01:23,840 +ال structure موجودة على cell membrane of the both + +17 +00:01:23,840 --> 00:01:29,940 +B and T cellفي ال B-cell ال PCR وفي ال T-cell ال + +18 +00:01:29,940 --> 00:01:39,800 +TCR وكما تشاهدون كل خلية محدودة فقط لأحد الانتجين + +19 +00:01:39,800 --> 00:01:43,360 +وعند + +20 +00:01:43,360 --> 00:01:51,620 +اكتبتها هناك اتجارة كلونية كل كلونية لديها مستخدم + +21 +00:01:51,620 --> 00:01:57,140 +مختلف كلهم يحبلوا نفس المستخدمfrom all other + +22 +00:01:57,140 --> 00:01:59,440 +receptors which can be distinguished easily طبعا + +23 +00:01:59,440 --> 00:02:04,620 +من from all other receptors ال clone تعريفا هو + +24 +00:02:04,620 --> 00:02:08,220 +عبارة عن ال parental cell حالية الأمر parental + +25 +00:02:08,220 --> 00:02:14,650 +lymphocytes and all its progeny كل خلفترةالـ PCR + +26 +00:02:14,650 --> 00:02:23,910 +هي عبارة عن Cell Surface Antigen Specific + +27 +00:02:23,910 --> 00:02:27,930 +Receptor بيرتبط + +28 +00:02:27,930 --> 00:02:32,230 +عالما بالـ Antigen Extracellular + +29 +00:02:33,140 --> 00:02:39,600 +وتحت بجانب هذا ال antigen specific receptor في + +30 +00:02:39,600 --> 00:02:46,820 +similar signaling بروتين موجود في both PCR وTCR + +31 +00:02:46,820 --> 00:02:56,960 +يوم يقبض ال antigen receptor with two or more + +32 +00:02:56,960 --> 00:03:02,260 +antigen يعني شرط أساسي كون في cross linking ال + +33 +00:03:04,270 --> 00:03:09,130 +هذه المجموعة من الموليكولات الهوائية الهوائية + +34 +00:03:09,130 --> 00:03:11,010 +الهوائية الهوائية الهوائية الهوائية الهوائية + +35 +00:03:11,010 --> 00:03:21,970 +الهوائية الهوائية الهوائية الهوائية + +36 +00:03:22,210 --> 00:03:25,510 +and initiate signal transduction طبعا بتنتين بتاني + +37 +00:03:25,510 --> 00:03:28,570 +صاروا صار في cross linking بتنتين بيجربوا زي بعض + +38 +00:03:28,570 --> 00:03:32,910 +جان بعض و بيصير في aggregating ل intracellularي و + +39 +00:03:32,910 --> 00:03:40,030 +بيبدأ ال signal transduction mechanism الا اذا كان + +40 +00:03:40,030 --> 00:03:46,410 +ال protein which induce signal transduction is the + +41 +00:03:46,410 --> 00:03:51,690 +same ال product is all be the same بمعنىالبروتين + +42 +00:03:51,690 --> 00:03:58,130 +المتوسط سيكون نفسه مرة أخرى إذا كان الانتجين اللي + +43 +00:03:58,130 --> 00:04:05,310 +عمل الوصول للبروتين + +44 +00:04:05,310 --> 00:04:16,070 +سيكون نفسه نفسه نفسه نفسه نفسه نفسه نفسه نفسه نفسه + +45 +00:04:16,070 --> 00:04:21,110 +نفسه نفسه نفسه نفسه نفسه نفسه نفسهمربعين مربعين + +46 +00:04:21,110 --> 00:04:25,930 +مربعين مربعين مربعين مربعين مربعين مربعين مربعين + +47 +00:04:25,930 --> 00:04:26,250 +مربعين مربعين مربعين مربعين مربعين مربعين مربعين + +48 +00:04:26,250 --> 00:04:27,590 +مرباعين مرباعين مرباعين مرباعين مرباعين مرباعين + +49 +00:04:27,590 --> 00:04:30,050 +مرباعين مرباعين مرباعين مرباعين مرباعين مرباعين + +50 +00:04:30,050 --> 00:04:30,690 +مرباعين مرباعين مرباعين مرباعين مرباعين مرباعين + +51 +00:04:30,690 --> 00:04:30,770 +مرباعين مرباعين مرباعين مرباعين مرباعين مرباعين + +52 +00:04:30,770 --> 00:04:31,310 +مرباعين مرباعين مرباعين مرباعين مرباعين مرباعين + +53 +00:04:31,310 --> 00:04:35,810 +مرباعين مرباعين مرباعين مرباعين مرباعين مرباعين + +54 +00:04:35,810 --> 00:04:42,630 +مرباعين مرباعين مرباعين مرباعين + +55 +00:04:47,650 --> 00:04:50,970 +continue recirculating until it found an antigen + +56 +00:04:50,970 --> 00:04:55,050 +وبرضه بتصير التوشة إذا رجت ال antigen في ال + +57 +00:04:55,050 --> 00:04:59,530 +secondary lymphoid organs هذا بالنسبة لل B + +58 +00:04:59,530 --> 00:05:06,990 +lymphocytes بيصير + +59 +00:05:06,990 --> 00:05:09,850 +maturation في ال bone marrow تطلع على blood + +60 +00:05:09,850 --> 00:05:10,790 +circulation + +61 +00:05:17,060 --> 00:05:21,800 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +62 +00:05:21,800 --> 00:05:21,800 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +63 +00:05:21,800 --> 00:05:22,480 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +64 +00:05:22,480 --> 00:05:24,700 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +65 +00:05:24,700 --> 00:05:26,480 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +66 +00:05:26,480 --> 00:05:28,180 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +67 +00:05:28,180 --> 00:05:32,360 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +68 +00:05:32,360 --> 00:05:32,360 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +69 +00:05:32,360 --> 00:05:32,360 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +70 +00:05:32,360 --> 00:05:32,360 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +71 +00:05:32,360 --> 00:05:32,360 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +72 +00:05:32,360 --> 00:05:37,400 +اللي + +73 +00:05:37,400 --> 00:05:38,000 +اللي + +74 +00:05:40,810 --> 00:05:44,390 +B-cell activation does not require antigen + +75 +00:05:44,390 --> 00:05:48,550 +presentation طب يعني احنا اتفقنا ان جورنا ال B + +76 +00:05:48,550 --> 00:05:54,670 +-cell عشان تتنشط تترتبط directly بالانتيجن B-cell + +77 +00:05:54,670 --> 00:06:00,010 +are active only against extracellular antigen + +78 +00:06:00,010 --> 00:06:03,670 +تتعرف على ال extracellular antigen + +79 +00:06:07,750 --> 00:06:13,670 +أنتوا شايفين كل خلية على سطحها Antibody نسميها + +80 +00:06:13,670 --> 00:06:18,270 +Antigen Specific Receptor وهذا ال Antibody can + +81 +00:06:18,270 --> 00:06:23,550 +recognize one Antigen although sometimes can + +82 +00:06:23,550 --> 00:06:30,930 +recognize different Antigen يعني each pixel توج + +83 +00:06:35,120 --> 00:06:43,060 +الخلية النايفة مرتبطة بالممبراين على نييف بي سيل + +84 +00:06:43,060 --> 00:06:48,340 +والنييف بي سيل هي عبارة عن الخلية نييفة التي لم + +85 +00:06:48,340 --> 00:06:53,620 +تواجهها انتجن قبل هيك انتجن plus second signal + +86 +00:06:53,620 --> 00:06:58,960 +stimulate ال بي سيل اكتر + +87 +00:06:58,960 --> 00:07:06,070 +بي سيل تخلق انتجنinto the blood and lymph or + +88 +00:07:06,070 --> 00:07:12,610 +patrolling mucosal surfaces 100% برضه ممكن يقعدوا + +89 +00:07:12,610 --> 00:07:17,570 +على الـ mucosal surfaces هي + +90 +00:07:17,570 --> 00:07:26,650 +ناييف بينفوسايت ارتبطت في انتجن من خلال PCR ونشطت + +91 +00:07:26,650 --> 00:07:33,990 +فبدت تفرز antibody نشيء ليهبيرتبط بنفس الانتجن لاش + +92 +00:07:33,990 --> 00:07:39,030 +ننسى ان ال PCR و ال secretant antibody both have + +93 +00:07:39,030 --> 00:07:44,250 +the same specificity لإنه هيرتبط بالانتجن ايش + +94 +00:07:44,250 --> 00:07:49,990 +specifically اللي نشطها ال transition from naive + +95 +00:07:49,990 --> 00:07:54,450 +to active cell بي سل secret modified version of B + +96 +00:07:54,450 --> 00:08:02,520 +cell receptor 100%من خلال رحلتها from naive to + +97 +00:08:02,520 --> 00:08:07,300 +active B cell ال B cell بس تبدأ تتنشط و تفرز هنا + +98 +00:08:07,300 --> 00:08:15,300 +modified version of B cell receptor طبعا هذا اول B + +99 +00:08:15,300 --> 00:08:19,680 +secret اللي بسموه ال antibodyPCR Uncorresponding + +100 +00:08:19,680 --> 00:08:23,360 +Antibody Share Identical Antispecificity قلت لكوا + +101 +00:08:23,360 --> 00:08:30,880 +لازم نعرف انه Secreted Antibody و ال PCR اللي قاعد + +102 +00:08:30,880 --> 00:08:37,360 +على السطح الخلية برضه لازم تنهي يعني Have or Share + +103 +00:08:37,360 --> 00:08:44,000 +Identical Specificity What are Antibodies؟ + +104 +00:08:44,000 --> 00:08:48,430 +Antibodies او بيسموهم immunoglobulinهي نوع من + +105 +00:08:48,430 --> 00:08:49,710 +عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة + +106 +00:08:49,710 --> 00:08:51,290 +عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن + +107 +00:08:51,290 --> 00:08:55,450 +عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة + +108 +00:08:55,450 --> 00:08:58,370 +عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن + +109 +00:08:58,370 --> 00:08:58,990 +عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة + +110 +00:08:58,990 --> 00:08:59,290 +عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن + +111 +00:08:59,290 --> 00:08:59,290 +عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة + +112 +00:08:59,290 --> 00:09:09,100 +عن عبارة عن عبارة عن عبارة عن عبارة عن عبارةوهي + +113 +00:09:09,100 --> 00:09:11,640 +الـ Structure of Antibody بالدياكو بس تنتبه على + +114 +00:09:11,640 --> 00:09:15,180 +الصورة الصورة بتقول انها this is a Y-shaped + +115 +00:09:15,180 --> 00:09:19,400 +structure وبيتكارى من أربع باري بيبتعد ال chain + +116 +00:09:19,400 --> 00:09:24,640 +هذا هو two identical light chain و two identical + +117 +00:09:24,640 --> 00:09:30,540 +heavy chain وهي ال light هذا هي ال light وهي ال + +118 +00:09:30,540 --> 00:09:36,080 +heavy شايفين ال heavy المعلنين بالأسود هدول ماشي؟ + +119 +00:09:37,710 --> 00:09:40,610 +وهي مرتبطة مع بعضها البعض بمعنى الـ disulfide bond + +120 +00:09:40,610 --> 00:09:47,470 +ويكسب المُركّب الـ Y شبكة الموليكيولية. كل شبكة + +121 +00:09:47,470 --> 00:09:49,650 +الإضاءة مرتبطة مع شبكة الهيبوت ومع بعض الـ + +122 +00:09:49,650 --> 00:09:53,170 +disulfide bond وكمان الشبكة الهيبوت مرتبطة مع بعض + +123 +00:09:53,170 --> 00:09:55,810 +ببعض الـ disulfide bond يعني ده هم التنتين هم + +124 +00:09:55,810 --> 00:10:00,410 +مرتبطين disulfide وdisulfide وهنا برضه في منطقة + +125 +00:10:00,410 --> 00:10:04,550 +عندنا بناسميها English regionAlso bind to each + +126 +00:10:04,550 --> 00:10:11,620 +other ننسى ان هناك انترسالفايت بونده دا هي ترتبط + +127 +00:10:11,620 --> 00:10:15,660 +من الداخل في الميليكيول وبالتالي الميليكيول وبران + +128 +00:10:15,660 --> 00:10:21,380 +ميليكيول متماسك صعب جدا انه ايش انه يعني it's not + +129 +00:10:21,380 --> 00:10:25,740 +it's resistant to degradation it's resistance to + +130 +00:10:25,740 --> 00:10:32,220 +degradation لكن هو بيقطع بواسطة ال two انزايم ال + +131 +00:10:32,220 --> 00:10:35,480 +Pepsin والPapine ويديحول ال combination اللي بيصير + +132 +00:10:36,540 --> 00:10:40,000 +antigen binding and effector domain are separated + +133 +00:10:40,000 --> 00:10:45,900 +هذه المنطقة بيسموها ال fab طبعا هذه بيسموها + +134 +00:10:45,900 --> 00:10:50,320 +antigen binding طيب وين اللي اللي اللي اللي اللي + +135 +00:10:50,320 --> 00:10:52,080 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +136 +00:10:52,080 --> 00:10:52,080 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +137 +00:10:52,080 --> 00:10:53,260 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +138 +00:10:53,260 --> 00:10:53,300 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +139 +00:10:53,300 --> 00:10:53,300 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +140 +00:10:53,300 --> 00:10:53,320 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +141 +00:10:53,320 --> 00:10:56,300 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +142 +00:10:56,300 --> 00:10:56,300 +اللي اللي اللي اللي اللي اللي اللي اللي اللي اللي + +143 +00:10:56,300 --> 00:11:04,480 +اللي اللي اللي اللي اللي اللي + +144 +00:11:04,480 --> 00:11:10,550 +اللي اللتحت تسميها الـ Fc portion كل ال biological + +145 +00:11:10,550 --> 00:11:14,390 +activity انتجن بيانديك و تحت فيه biological + +146 +00:11:14,390 --> 00:11:19,570 +activity الانتجن + +147 +00:11:19,570 --> 00:11:22,470 +ريسبتور هي ال testing domain زي ما انتوا شايفين كل + +148 +00:11:22,470 --> 00:11:26,130 +globular portion ده هو ال globular بقى بره ال + +149 +00:11:26,130 --> 00:11:32,150 +domain ماشي؟ and it's functional domainIt's a + +150 +00:11:32,150 --> 00:11:36,270 +functional domain الـ variable ده هي variable + +151 +00:11:36,270 --> 00:11:42,630 +مقصود فيها VH و VL VH ال variable heavy يعني و VL + +152 +00:11:42,630 --> 00:11:47,510 +يعني ال variable light ال V ال variable agent + +153 +00:11:47,510 --> 00:11:52,390 +varies between clone تختلف في اختلاف ال clone وهي + +154 +00:11:52,390 --> 00:11:55,870 +المسؤولة عن ال antigen recognition عشان هيك ال + +155 +00:11:55,870 --> 00:12:01,790 +specificity تحدد من هذه المنطقة وبعد ما أقولانت + +156 +00:12:01,790 --> 00:12:05,290 +تحت هو عبارة عن constant region هو عبارة عن ناشر + +157 +00:12:05,290 --> 00:12:07,350 +constant region وفيه ال effector function ال + +158 +00:12:07,350 --> 00:12:10,710 +biological function زي ما قلت لكوا في هذه المناطق + +159 +00:12:10,710 --> 00:12:19,090 +ال body structure or architecture بوجوده + +160 +00:12:19,090 --> 00:12:22,470 +بهذا الشكل يسمح بوجود multiple highly diverse + +161 +00:12:22,470 --> 00:12:27,550 +antigen to induce an identical effector function + +162 +00:12:27,550 --> 00:12:32,530 +شايفين زي ما انتوا شايفينفي أن أنتي بتلاتة + +163 +00:12:32,530 --> 00:12:37,310 +antibody الفاب region في كل واحد مختلف وبالتالي كل + +164 +00:12:37,310 --> 00:12:41,750 +واحد هيضطر يتبعيش different antigen لكن ال + +165 +00:12:41,750 --> 00:12:45,210 +constant region واحدة معناته ال antibody في هذا + +166 +00:12:45,210 --> 00:12:51,570 +الحالة واحد لأن ال antibody class يعرف من خلال ال + +167 +00:12:51,570 --> 00:12:54,150 +hybrid chain وليس ال dotted chain فالhybrid chain + +168 +00:12:54,150 --> 00:13:00,770 +نفسها واحدة يبدأ ال antibody class واحدماشي فانه + +169 +00:13:00,770 --> 00:13:05,330 +ان كل antibody class واحد معناته ال signal ال + +170 +00:13:05,330 --> 00:13:10,850 +transduction بتكون ايه اش واحدة يعني طبعا هو + +171 +00:13:10,850 --> 00:13:15,790 +different variable region ده هي شايفين different + +172 +00:13:15,790 --> 00:13:22,030 +variable region بترتبط ب different antigen لكن + +173 +00:13:22,030 --> 00:13:28,320 +identical constant region ده هيinduce identical + +174 +00:13:28,320 --> 00:13:35,020 +response each + +175 +00:13:35,020 --> 00:13:40,380 +lighted chain contain one variable one constant كل + +176 +00:13:40,380 --> 00:13:47,440 +lighted chain فيها و VL و فيها CL VL و CL and each + +177 +00:13:47,440 --> 00:13:54,700 +heavy chain contain one V هذا هي و + +178 +00:13:56,580 --> 00:14:03,160 +At least تلاتة هذه هي CH واحد CH اتنين CH تلاتة At + +179 +00:14:03,160 --> 00:14:10,280 +least تلاتة ممكن يكون اربع ماشي CH تلاتة constant + +180 +00:14:10,280 --> 00:14:14,720 +domain and + +181 +00:14:14,720 --> 00:14:21,460 +each domain fold وكل domain بي fold بيتشكل يعني + +182 +00:14:21,460 --> 00:14:27,650 +بيفردانتقل الى شكل ثلاثمائية من الشكل الانتقالي + +183 +00:14:27,650 --> 00:14:35,530 +انتقال الى شكل ثلاثمائية من الشكل الانتقالي انتقال + +184 +00:14:35,530 --> 00:14:36,270 +الى شكل ثلاثمائية من الشكل الانتقالي انتقال الى + +185 +00:14:36,270 --> 00:14:36,630 +شكل ثلاثمائية من الشكل الانتقالي انتقال الى شكل + +186 +00:14:36,630 --> 00:14:36,630 +ثلاثمائية من الشكل الانتقالي انتقال الى شكل + +187 +00:14:36,630 --> 00:14:37,650 +ثلاثمائية من الشكل الانتقالي انتقال الى شكل + +188 +00:14:37,650 --> 00:14:40,690 +ثلاثمائية من الشكل الانتقالي انتقال الى شكل + +189 +00:14:40,690 --> 00:14:42,010 +ثلاثمائية من الشكل الانتقالي انتقال الى شكل + +190 +00:14:42,010 --> 00:14:51,710 +ثلاثمائية من الشكل الانتقالي انتقال الى + +191 +00:14:51,710 --> 00:14:53,850 +شكلأو عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن + +192 +00:14:53,850 --> 00:14:55,150 +عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة + +193 +00:14:55,150 --> 00:14:57,530 +عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن + +194 +00:14:57,530 --> 00:15:02,270 +عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة + +195 +00:15:02,270 --> 00:15:02,450 +عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن + +196 +00:15:02,450 --> 00:15:03,170 +عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة + +197 +00:15:03,170 --> 00:15:03,170 +عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن + +198 +00:15:03,170 --> 00:15:12,830 +عبارة عن عبارة عن عبارة عن عبارة عن عبارة عن عبارة + +199 +00:15:12,830 --> 00:15:19,090 +عن عبوالـ Epitope can be recognized on the basis + +200 +00:15:19,090 --> 00:15:24,470 +of sequence or shape طبعا حسب شكله وحسب إيه ال + +201 +00:15:24,470 --> 00:15:29,490 +sequence تبعه ال affinity هي قوة الرابط ما بين one + +202 +00:15:29,490 --> 00:15:34,330 +fab و one epitope بينما ال avidity هي عبارة عن + +203 +00:15:34,330 --> 00:15:40,830 +مجموع الروابط أو القوة اللي بتتشكل من خلال رابط + +204 +00:15:42,010 --> 00:15:48,090 +مابين اتنين لعشرة antigen binding sites لإنه على + +205 +00:15:48,090 --> 00:15:55,790 +سبيل المثال في عندنا ال IGM في خمسة antigen + +206 +00:15:55,790 --> 00:15:56,650 +binding sites + +207 +00:15:59,390 --> 00:16:03,050 +فاليوم اللي بتقعد في الدار هذه ببساطة بتعملنا لخمة + +208 +00:16:03,050 --> 00:16:06,590 +في عندها من اتنين لعشرة antigen binding sites + +209 +00:16:06,590 --> 00:16:11,350 +وبالتالي كل antibody ممكن يرتبط من اتنين لعشرة + +210 +00:16:11,350 --> 00:16:16,370 +Epitopes ممكن يرتبط في ايش؟ في من اتنين لعشرة + +211 +00:16:16,370 --> 00:16:23,550 +Epitopes طبعا ال Epitopes ممكن يكونوا identical أو + +212 +00:16:23,550 --> 00:16:27,160 +sufficiently close togetherعلى سبيل المثال + +213 +00:16:27,160 --> 00:16:32,080 +Microbial Cell Membrane Surface Protein In this + +214 +00:16:32,080 --> 00:16:37,420 +case, the binding is much greater than affinity + +215 +00:16:37,420 --> 00:16:43,020 +Affinity of what of a single antibody-antigen bond + +216 +00:16:43,020 --> 00:16:49,380 +and it's called avidity.زي ما انتوا شايفين اليوم + +217 +00:16:49,380 --> 00:16:56,160 +يوعد complementary للتاني الابيتوبهو الانتيجم + +218 +00:16:56,160 --> 00:17:00,420 +البراتوب اللي فيه على الشكلية على سطح الانتيبادي + +219 +00:17:00,420 --> 00:17:06,580 +وعلى سطح الانتيجم هذه العياب التي تؤثر على + +220 +00:17:06,580 --> 00:17:12,160 +الانتيجم recognition جالس من رواحة الانتيبادي + +221 +00:17:12,160 --> 00:17:19,200 +recognize large three or three dimensions طب هيكون + +222 +00:17:19,200 --> 00:17:25,390 +عدد كبير من three dimensionsEach clone is specific + +223 +00:17:25,390 --> 00:17:39,970 +for a single antigen Antigen + +224 +00:17:39,970 --> 00:17:43,550 +recognition is mediated by a specific domain اللي + +225 +00:17:43,550 --> 00:17:48,190 +بيمسك في الantigen specifically هو عبارة عن + +226 +00:17:48,190 --> 00:17:50,010 +specific domain + +227 +00:17:52,340 --> 00:17:59,040 +Signaling Triggered By Cell Activation وكما + +228 +00:17:59,040 --> 00:18:04,620 +تشاهدون هذا مرعن فجر وهو الـ Membrane Bound Cell + +229 +00:18:04,620 --> 00:18:09,440 +Surface Antibody أو البروتين مرتبط بانتجن وهي اللي + +230 +00:18:09,440 --> 00:18:15,720 +بيقولنا الـ immunoglobulin Alpha Beta عملت Signal + +231 +00:18:15,720 --> 00:18:20,740 +Signaling وطلع التأثيرات القاتية طلع ال effector + +232 +00:18:20,740 --> 00:18:26,300 +function يعنيبممكن تعمل كمبلمنت فرق فكسيشن و + +233 +00:18:26,300 --> 00:18:32,060 +phagocystic binding طب + +234 +00:18:32,060 --> 00:18:35,680 +نشوف إيش الصفات forms of antigen, macromolecules, + +235 +00:18:36,640 --> 00:18:45,080 +and polysaccharides و نكليك أسد diversity + +236 +00:18:45,080 --> 00:18:51,300 +from conformational changes ابتوب and linear ابتوب + +237 +00:18:51,960 --> 00:18:57,640 +Diversity في عشر القوة تسعة Potentially unique + +238 +00:18:57,640 --> 00:19:06,460 +specific Antibody ال Antigen recognition is + +239 +00:19:06,460 --> 00:19:11,760 +mediated by ال variable region والله تتشين هذه ال + +240 +00:19:11,760 --> 00:19:12,020 +region + +241 +00:19:15,020 --> 00:19:18,400 +السيجنالينج بروتيم Alpha-Aminoglobulin Alpha + +242 +00:19:18,400 --> 00:19:21,280 +-Aminoglobulin Beta associated with Membrane + +243 +00:19:21,280 --> 00:19:27,280 +Aminoglobulin البيسيل + +244 +00:19:27,280 --> 00:19:31,140 +يحتاج إلى اكتيفاش طبيعي جدا البيسيل مستقل + +245 +00:19:33,640 --> 00:19:35,980 +تسل ديبندنت اندبندنسري + +246 +00:20:09,260 --> 00:20:15,440 +PATHOGEN RECOGNITION RECEPTOR يبقى + +247 +00:20:15,440 --> 00:20:18,580 +هاي ال two signal لازم أول واحدة تمسك وبعدين + +248 +00:20:18,580 --> 00:20:22,680 +التانية تمسك متى ما مسكت تتنشط ال بي سيل وزي ما + +249 +00:20:22,680 --> 00:20:26,840 +تشوفين هي أتلونت للون الأحمر وصارت active بي سيل + +250 +00:20:26,840 --> 00:20:32,880 +مينجواسيني يعني plasma cellT cell dependent تعتمد + +251 +00:20:32,880 --> 00:20:35,620 +على T cell تعتمد على T lymphocyte تعتمد على T + +252 +00:20:35,620 --> 00:20:40,360 +lymphocyte تعتمد على T lymphocyte تعتمد على T + +253 +00:20:40,360 --> 00:20:43,380 +lymphocyte تعتمد على T lymphocyte تعتمد على T + +254 +00:20:43,380 --> 00:20:43,380 +lymphocyte تعتمد على T lymphocyte تعتمد على T + +255 +00:20:43,380 --> 00:20:43,940 +lymphocyte تعتمد على T lymphocyte تعتمد على T + +256 +00:20:43,940 --> 00:20:43,940 +lymphocyte تعتمد على T lymphocyte تعتمد على T + +257 +00:20:43,940 --> 00:20:43,940 +lymphocyte تعتمد على T lymphocyte تعتمد على T + +258 +00:20:43,940 --> 00:20:43,940 +lymphocyte تعتمد على T lymphocyte تعتمد على T + +259 +00:20:43,940 --> 00:20:43,940 +lymphocyte تعتمد على T lymphocyte تعتمد على T + +260 +00:20:43,940 --> 00:20:46,480 +lymphocyte تعتمد على T lymphocyte تعتمد على T + +261 +00:20:46,480 --> 00:20:50,240 +lymphocyte تعتمد على T lymphocyte تعتمد على T + +262 +00:20:50,240 --> 00:20:58,420 +lymphocyte تعتمد على T lymphocyte تعتمد على T + +263 +00:20:58,420 --> 00:21:06,900 +lymphعلى سطحها ريسيبتور لانتبوكين 2 وعلى سطحها Mhc + +264 +00:21:06,900 --> 00:21:11,920 +موليكول 2 اللي عنده القدرة ان يرتبط بالانتجار اخد + +265 +00:21:11,920 --> 00:21:16,180 +الانتجار وعمله processing مين تعرفت عليه هى ال Mhc + +266 +00:21:16,180 --> 00:21:24,780 +موليكول وهى اللي ايه اش ال process طيب + +267 +00:21:24,780 --> 00:21:28,170 +شو يبقى C في هذه الحالةأو الـ Two-Signal في الـ T + +268 +00:21:28,170 --> 00:21:30,470 +-Cell Dependent جالو الـ Two-Signal الأولى مياه + +269 +00:21:30,470 --> 00:21:34,910 +انتجة من خلال الـ PCR والتانية Releasing of + +270 +00:21:34,910 --> 00:21:45,310 +cytokine التانية إيش؟ Releasing of cytokine الـ + +271 +00:21:45,310 --> 00:21:49,990 +Isotypes جالو فيه خمس أنواع من الـ Hemoglobin من + +272 +00:21:49,990 --> 00:21:58,160 +الـ Heavy Chain اللي بتختلف عن الـ C-RegionEach + +273 +00:21:58,160 --> 00:22:03,960 +class is an isotope of a group of individuals.Each + +274 +00:22:03,960 --> 00:22:09,880 +class is an isotope of a group of individuals.Each + +275 +00:22:09,880 --> 00:22:14,260 +isotope يختلف physiologically and biologically + +276 +00:22:14,260 --> 00:22:23,780 +from a defector function.ولو بدنا نحكي عن ال IGE + +277 +00:22:25,630 --> 00:22:29,810 +يعني هو قدر عن Diamer وإن كان فيه إمكانية يكون + +278 +00:22:29,810 --> 00:22:37,770 +Monomer ماشي وفيه إمكانية يكون Diamer ماشي شو اللي + +279 +00:22:37,770 --> 00:22:43,410 +بيعملوا؟ قالوا ده هو موجود على شكل Diamer اللي + +280 +00:22:43,410 --> 00:22:49,010 +ارتبطت ب FC Porsche + +281 +00:22:49,010 --> 00:22:53,830 +شو + +282 +00:22:53,830 --> 00:22:58,510 +بتتم العملية؟ قلناالـ plasma cell عادة بتصنع ان + +283 +00:22:58,510 --> 00:23:03,370 +IGA IGA محله في الـ mucous membrane فبالتالي بدي + +284 +00:23:03,370 --> 00:23:07,470 +يطلع ال IGA من ال tissue و يخترق ال cell membrane + +285 +00:23:07,470 --> 00:23:11,850 +اللي هو عبارة عن ال epithelial cells و يطلع برا + +286 +00:23:11,850 --> 00:23:17,630 +على ال mucous membrane كذا بالتم العملية نالو ال + +287 +00:23:17,630 --> 00:23:27,600 +plasma cell secret ال IGA و ال IGAو مجرد ما يستدعى + +288 +00:23:27,600 --> 00:23:32,380 +ماشي بروحه مرتبط باتنشط و برتبط في إيش؟ في الـ + +289 +00:23:32,380 --> 00:23:36,100 +epithelial cells المبطنة لجدار الـ mucous membrane + +290 +00:23:36,100 --> 00:23:40,580 +الداخلي برتبط ورينجاله برتبط الـ preceptor بيسموه + +291 +00:23:40,580 --> 00:23:45,440 +poly immunoglobulin و بعدها بيخش في داخل ال tissue + +292 +00:23:45,440 --> 00:23:52,040 +على شكل physical ماشي؟ و ال physical ها دي معرضة + +293 +00:23:52,040 --> 00:23:59,030 +لإيش؟ ل slideاللي هو activation + +294 +00:23:59,030 --> 00:24:05,190 +شو بيحصل فيها جرب يحصل فيه enzymatic degradation + +295 +00:24:05,190 --> 00:24:09,930 +بيطلعوا يكسروا اللي هو ال poly immunoglobulin اللي + +296 +00:24:09,930 --> 00:24:17,010 +أخدنا ناشي و لما تكسروا تطلع برا ال physical لكن و + +297 +00:24:17,010 --> 00:24:21,230 +لما نزلنا نطلع لعب نلاقيها ماشي مافيشش اللي هو + +298 +00:24:21,230 --> 00:24:26,410 +poly immunoglobulin لكن فيه remnantof it و الـ + +299 +00:24:26,410 --> 00:24:33,070 +remnant of it يسموها secretory substance secretory + +300 +00:24:33,070 --> 00:24:36,150 +substance وظيفتها الأساسية انها تحافظ على + +301 +00:24:36,150 --> 00:24:41,730 +الموليكيور from degradation from ايه؟ from + +302 +00:24:41,730 --> 00:24:50,450 +degradation IGD لليوم ال function is unknown لكنه + +303 +00:24:50,450 --> 00:24:56,070 +مستمرا موجود على ال membraneوولا عمره وصلوا + +304 +00:24:56,070 --> 00:25:01,770 +expression on active B cell بيقولوا ان ال IGD + +305 +00:25:01,770 --> 00:25:05,530 +knockout mice don't have any apparent effects يعني + +306 +00:25:05,530 --> 00:25:12,990 +مايله أي significance مايله أيش أي significance بس + +307 +00:25:12,990 --> 00:25:18,170 +بيقولوا انه احد الأبحاث أو الدلائل العلمية بتقول + +308 +00:25:18,170 --> 00:25:24,440 +ان ال IGD بالعفو دوري كبير فيعملية قبل الـ self + +309 +00:25:24,440 --> 00:25:41,420 +-reactive cells او الموليكولوجيا او + +310 +00:25:41,420 --> 00:25:41,820 +الموليكولوجيا او الموليكولوجيا او الموليكولوجيا او + +311 +00:25:41,820 --> 00:25:41,820 +الموليكولوجيا او الموليكولوجيا او الموليكولوجيا او + +312 +00:25:41,820 --> 00:25:41,820 +الموليكولوجيا او الموليكولوجيا او الموليكولوجيا او + +313 +00:25:41,820 --> 00:25:41,820 +الموليكولوجيا او الموليكولوجيا او الموليكولوجيا او + +314 +00:25:41,820 --> 00:25:41,900 +الموليكولوجيا او الموليكولوجيا او الموليكولوجيا او + +315 +00:25:41,900 --> 00:25:42,620 +الموليكولوجيا او الموليكولوجيا او الموليكولوجيا او + +316 +00:25:42,620 --> 00:25:47,520 +الموليكولوجيا او الموليكولوجيا او الموليكولوجيا او + +317 +00:25:47,520 --> 00:25:56,170 +الموليكولوجيا او الموليأبسلون ريسبتور وهذا هو + +318 +00:25:56,170 --> 00:26:00,490 +الانسان + +319 +00:26:00,490 --> 00:26:07,190 +اللي بدنا نحكي عنه هي موليكيول هي موليكيول هي + +320 +00:26:07,190 --> 00:26:08,050 +موليكيول هي موليكيول هي موليكيول هي موليكيول هي + +321 +00:26:08,050 --> 00:26:08,050 +موليكيول هي موليكيول هي موليكيول هي موليكيول هي + +322 +00:26:08,050 --> 00:26:08,310 +موليكيول هي موليكيول هي موليكيول هي موليكيول هي + +323 +00:26:08,310 --> 00:26:08,910 +موليكيول هي موليكيول هي موليكيول هي موليكيول هي + +324 +00:26:08,910 --> 00:26:09,930 +موليكيول هي موليكيول هي موليكيول هي موليكيول هي + +325 +00:26:09,930 --> 00:26:12,110 +موليكيول هي موليكيول هي موليكيول هي موليكيول هي + +326 +00:26:12,110 --> 00:26:19,170 +موليكيول هي موليكيول + +327 +00:26:19,170 --> 00:26:25,900 +هيأصبح هناك Degranulation و Activation للخلية لابد + +328 +00:26:25,900 --> 00:26:32,680 +من تنشيط ال .. ال + +329 +00:26:32,680 --> 00:26:39,780 +.. ال Complex طيب، أيش اللي بصير؟ جالوا يوم تتنشط + +330 +00:26:39,780 --> 00:26:43,060 +الخلية من هذا ال Complex، كنا لازم يصير في Cross + +331 +00:26:43,060 --> 00:26:49,300 +-linkingبتنشط الخلية وبتطلع لنا جرانيوز وقلنا ان + +332 +00:26:49,300 --> 00:26:57,000 +جرانيوز أشهرها الهستامين والهيبرين وكان يلعب دور + +333 +00:26:57,000 --> 00:27:06,560 +كبير في IGE في قتل ال parasites IGG + +334 +00:27:06,560 --> 00:27:11,960 +ايوة حوالي ست سبعة وظائف قلنا ان امر واحد + +335 +00:27:14,350 --> 00:27:17,150 +نتراليزيشن نتراليزيشن نتراليزيشن نتراليزيشن + +336 +00:27:17,150 --> 00:27:17,650 +نتراليزيشن نتراليزيشن نتراليزيشن نتراليزيشن + +337 +00:27:17,650 --> 00:27:22,690 +نتراليزيشن نتراليزيشن نتراليزيشن + +338 +00:27:22,690 --> 00:27:27,630 +نتراليزيشن نتراليزيشن نتراليزيشن نتراليزيشن + +339 +00:27:27,630 --> 00:27:28,550 +نتراليزيشن نتراليزيشن نتراليزيشن نتراليزيشن + +340 +00:27:28,550 --> 00:27:36,010 +نتراليزيشن نتراليزيشن نتراليزيشن نتراليزيشن + +341 +00:27:36,010 --> 00:27:43,210 +نتراليزيشن نتراليزيش + +342 +00:27:45,860 --> 00:27:53,720 +الـ IGG يعمل كـ Obscenizer بعمل Coating للـ + +343 +00:27:53,720 --> 00:28:02,120 +Pathogen ويمنع دخوله إلى الـ Host Cell في + +344 +00:28:02,120 --> 00:28:07,680 +الـ Infectious Pathogen يدخل الـ Host Cell لتشغيله + +345 +00:28:07,680 --> 00:28:10,800 +لما + +346 +00:28:10,800 --> 00:28:15,600 +يدخلالـ pathogen إلى داخل الخلية معناته بده يعمل + +347 +00:28:15,600 --> 00:28:20,520 +propagation pathogen cannot enter cell when coated + +348 +00:28:20,520 --> 00:28:24,660 +with antibody يوم ما هدرت بال cell surface + +349 +00:28:24,660 --> 00:28:28,460 +membrane واتعلم الخلية من برا ما بيصير فيه عملية + +350 +00:28:28,460 --> 00:28:35,540 +إيش يعني + +351 +00:28:35,540 --> 00:28:44,910 +ما بيصيرش عملية اللي هو إيشالـ propagation و ال + +352 +00:28:44,910 --> 00:28:55,270 +killing بهذه الطريقة من برا لبرا ايضا + +353 +00:28:55,270 --> 00:28:58,850 +استكمالا لل IGG زى ما انتوا شايفين IGG + +354 +00:29:03,620 --> 00:29:09,960 +على سطح كل الفاجوة ستكسل وهنا مثال على Macrophage + +355 +00:29:09,960 --> 00:29:16,180 +هي مرتبطة بالفاجوة الاف سي بورشين once + +356 +00:29:16,180 --> 00:29:24,180 +it binds the antigen بيصير في فاجوه سيتوسس بيخش + +357 +00:29:24,180 --> 00:29:30,180 +على شكل physical بيكون فاجوه زوم و الفاجوه زوم بي + +358 +00:29:31,670 --> 00:29:37,170 +يرتطم بالـ Lysosome بكون فاجو الـ Lysosome و + +359 +00:29:37,170 --> 00:29:40,590 +الميكروبيل البيبتايد موجودة على سطح الـ MC Class + +360 +00:29:40,590 --> 00:29:48,190 +II الملكيومي و الـ CD4 T Cell Activation و هذه + +361 +00:29:48,190 --> 00:29:52,590 +الطرق التنشيطة طبعا أيضا الـ FC Receptor also + +362 +00:29:52,590 --> 00:29:56,670 +مدينة Antibody مدينة Cell Mediated Cytotoxicity + +363 +00:29:56,670 --> 00:30:06,100 +وهي ال target cellعلى سطح الـ Multiple Epitope + +364 +00:30:06,100 --> 00:30:11,640 +طبعاً الـ Minoglobulin بيند الـ Antigen على سطح + +365 +00:30:11,640 --> 00:30:18,540 +الـ Target Cell اللي فالت هو الـ Fc Portion وطبعا + +366 +00:30:18,540 --> 00:30:24,100 +الـ Fc Receptor على سطح الـ Natural Killer Cell و + +367 +00:30:24,100 --> 00:30:29,680 +الـ Bind to Fc of Minoglobulinمعاقبة الـ Fc + +368 +00:30:29,680 --> 00:30:38,580 +ريسيبتور لجهزة الـ NK لقتل الهدف الهدف + +369 +00:30:38,580 --> 00:30:42,380 +الهدف يموت من الابتعاد الهدف الهدف الهدف الهدف + +370 +00:30:42,380 --> 00:30:49,380 +الهدف الهدف الهدف الهدف الهدف الهدف الهدف الهدف + +371 +00:30:49,380 --> 00:30:49,840 +الهدف الهدف الهدف الهدف الهدف الهدف الهدف الهدف + +372 +00:30:49,840 --> 00:30:49,840 +الهدف الهدف الهدف الهدف الهدف الهدف الهدف الهدف + +373 +00:30:49,840 --> 00:30:50,340 +الهدف الهدف الهدف الهدف الهدف الهدف الهدف الهدف + +374 +00:30:50,340 --> 00:30:54,600 +الهدف الهدف الهدف الهدف الهدف الهدف الهدف اله + +375 +00:30:55,100 --> 00:31:02,220 +زي الـ IGA بـ J-Region J-Region وطبعاً بيعتبر هو + +376 +00:31:02,220 --> 00:31:05,280 +أول antibody بيخرجش لما بتتمشط ال match و بي + +377 +00:31:05,280 --> 00:31:09,620 +lymphocytes important activation of the complement + +378 +00:31:09,620 --> 00:31:20,480 +وكمان له دور كبير في ال after infection و + +379 +00:31:26,900 --> 00:31:32,500 +بنشوفه بكثرة طيب احنا يعني ارجو ان تكونوا قد + +380 +00:31:32,500 --> 00:31:35,040 +استفدتم يكفينا هذه المعلومات عن ال antibody + +381 +00:31:35,040 --> 00:31:38,100 +function and structure + +382 +00:32:43,250 --> 00:32:44,270 +الله أحسنها + diff --git a/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/PUixi-Psy3Y.srt b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/PUixi-Psy3Y.srt new file mode 100644 index 0000000000000000000000000000000000000000..268535be7e11695ac75a17bd75e1429a172f8c84 --- /dev/null +++ b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/PUixi-Psy3Y.srt @@ -0,0 +1,1995 @@ +1 +00:00:02,530 --> 00:00:07,590 +بسم الله الرحمن الرحيم وصلنا + +2 +00:00:07,590 --> 00:00:12,330 +الآن إلى الـ immunoclinical immunology أو clinical + +3 +00:00:12,330 --> 00:00:19,850 +immunology part و هنبدأ بالـ immunopathology والـ + +4 +00:00:19,850 --> 00:00:27,150 +disorders of immune response ويقسموها إلى ثلاث + +5 +00:00:27,150 --> 00:00:32,200 +أنواع أساسية، إما exaggerated يعني over + +6 +00:00:32,200 --> 00:00:35,580 +reactive in your response وبتتمثل + +7 +00:00:35,580 --> 00:00:42,660 +بالـ hypersensitivity reaction وإما deficient وطبعا + +8 +00:00:43,920 --> 00:00:49,740 +المثال عليها immunodeficiency أو misdirected وطبعا + +9 +00:00:49,740 --> 00:00:54,640 +هذا هنحكي فيه الـ autoimmune disease هنبدأ في أول + +10 +00:00:54,640 --> 00:00:58,060 +معنى هو الـ hypersensitivity reaction وطبعا هذا + +11 +00:00:58,060 --> 00:01:02,240 +الجدول بيبين أن الأربع أنواع مختلفة من الـ + +12 +00:01:02,240 --> 00:01:06,100 +hypersensitivity reaction وإذا بتلاحظوا أول ثلاث + +13 +00:01:06,100 --> 00:01:09,480 +هم عبارة عن antibody mediated بينما النوع الرابع + +14 +00:01:09,480 --> 00:01:11,540 +هو عبارة عن cell mediated immunity + +15 +00:01:14,540 --> 00:01:26,020 +هنحكي على كل من هما بالتفصيل نفس + +16 +00:01:26,020 --> 00:01:34,080 +الصورة نفس + +17 +00:01:39,850 --> 00:01:42,970 +يأتي في الـ Type I Hypersensitivity Reaction أو ما + +18 +00:01:42,970 --> 00:01:49,070 +تسمى بالـ Classical Allergy الـ Antibody المسؤول + +19 +00:01:49,070 --> 00:01:52,690 +عن الموضوع هو عبارة عن IgE Antibody بيرتبط بالماست سيل + +20 +00:01:52,690 --> 00:01:56,090 +والبيزوفيل الريسبترو على سطح الماست سيل والبيزوفيل + +21 +00:01:56,090 --> 00:02:06,350 +ويوم ما تحدث محصلة الـ reaction هو عبارة عن + +22 +00:02:06,350 --> 00:02:07,250 +Anaphylactic Shock + +23 +00:02:13,230 --> 00:02:19,390 +هذه الطريقة تستخدم في الانتيبادي الـ IgE IgE IgE + +24 +00:02:19,390 --> 00:02:20,950 +IgE IgE IgE IgE IgE IgE IgE IgE IgE IgE + +25 +00:02:20,950 --> 00:02:23,490 +IgE IgE IgE IgE IgE IgE IgE IgE IgE IgE + +26 +00:02:23,490 --> 00:02:28,690 +IgE IgE IgE IgE IgE IgE IgE IgE IgE IgE + +27 +00:02:28,690 --> 00:02:29,510 +IgE IgE IgE IgE IgE IgE IgE IgE IgE IgE + +28 +00:02:29,510 --> 00:02:31,970 +IgE IgE IgE IgE IgE IgE IgE IgE IgE + +29 +00:02:34,910 --> 00:02:40,950 +far away from protection بمعنى أنه it may lead to + +30 +00:02:40,950 --> 00:02:44,950 +death طبعا فيه قدر صعب ممكن نشوفها زي الـ hay fever + +31 +00:02:44,950 --> 00:02:48,270 +والأزمة والـ eczema والـ bee stings والـ food + +32 +00:02:48,270 --> 00:02:52,270 +allergy كلها دول can be included in such type + +33 +00:02:52,270 --> 00:03:00,010 +of hypersensitivity الـ allergen هو عبارة عن non + +34 +00:03:00,010 --> 00:03:04,480 +parasitic antigen الذي يمكن أن يشبه تطبيق الـ + +35 +00:03:04,480 --> 00:03:08,880 +Hypersensitivity response الأليرجين هو اللي بيثبت + +36 +00:03:08,880 --> 00:03:16,020 +بالـ IgE ويشبه تنسيق ميدياتر كيميائي من الماست سيل + +37 +00:03:16,020 --> 00:03:24,690 +والبيزوفيل مثل الأليرجين زي الـ proteins منها Serum + +38 +00:03:24,690 --> 00:03:28,890 +protein والفاكسين، plant pollen، drugs زي + +39 +00:03:28,890 --> 00:03:31,850 +البنسلين، السلفاناميد، الوكالة، الاناستيزيا، + +40 +00:03:31,850 --> 00:03:37,730 +foods زي الناتس والإيجز والإنسكت، + +41 +00:03:37,730 --> 00:03:42,670 +product زي الـ bee venom and dust mites، molds، + +42 +00:03:42,670 --> 00:03:46,090 +animal hair and dander كل هذا عبارة عن أمثلة + +43 +00:03:46,090 --> 00:03:52,770 +للأليرجين وما أكثرها طبعا اليوم زادت مع التطور + +44 +00:03:52,770 --> 00:03:57,930 +اللي إحنا قاعدين بعيننا نعيشه في الحياة ما هي صفات + +45 +00:03:57,930 --> 00:04:02,330 +الأليرجين؟ دول عبارة عن small molecular weight + +46 +00:04:02,330 --> 00:04:07,010 +protein بيصل molecular weight تبعه ما بين it range + +47 +00:04:07,010 --> 00:04:12,220 +ما بين fifteen to forty thousands يعتبر specific + +48 +00:04:12,220 --> 00:04:17,800 +protein components في الغالب إنزيم it can act in + +49 +00:04:17,800 --> 00:04:23,000 +low dose and it can break the mucous mucosal + +50 +00:04:23,000 --> 00:04:29,340 +membrane وطبعا معظم الـ allergens بيpromote الـ immune + +51 +00:04:29,340 --> 00:04:34,720 +response وطبعا أحسن مثال على الـ allergen زي ما + +52 +00:04:34,720 --> 00:04:39,750 +أنتوا شايفين اللي هو DRP1 إنزيم والدير بي ون + +53 +00:04:39,750 --> 00:04:43,710 +إنزيم بتطلع منها دي هي الـ fecal pellets of + +54 +00:04:43,710 --> 00:04:47,890 +dust mites هذي يبرن dust mites هي Dermatophagoides + +55 +00:04:47,890 --> 00:04:51,510 +pteronyssinus + +56 +00:04:51,510 --> 00:04:58,310 +سيمنس هذي اسمها دي هي هذي dust mites يعني موجودة + +57 +00:04:58,310 --> 00:05:04,030 +في الغبار شوفين إيش بتعمل هاي ميوكاس مبرين + +58 +00:05:04,030 --> 00:05:12,190 +contact ميوكاس مبرين بيصير فيه stench of الواحد اللي + +59 +00:05:12,190 --> 00:05:18,790 +هو الـ fecal mites وبتحتوي على الـ DRP-1 شو عمل الـ + +60 +00:05:18,790 --> 00:05:26,550 +DRP-1 عمل breaking للـ connection + +61 +00:05:26,550 --> 00:05:33,430 +between epithelial cells وبالتالي عمل فتحة دخل + +62 +00:05:34,390 --> 00:05:38,970 +تلقفته antigen-presenting cell قدمته لـ T + +63 +00:05:38,970 --> 00:05:44,270 +-lymphocytes والـ T-lymphocyte نشطت بي سيل فطبعا + +64 +00:05:44,270 --> 00:05:48,830 +طلعتلنا antibody الـ antibody قاعد على سطح الماست سيل + +65 +00:05:48,830 --> 00:05:53,410 +والبيزوفيل و upon second content a second + +66 +00:05:53,410 --> 00:05:58,990 +exposure بيصير في ارتباط و cross-linking للـ + +67 +00:05:58,990 --> 00:06:02,390 +Antibody مع الـ Antigen على سطح الماست سيل والبيزوفيل + +68 +00:06:02,390 --> 00:06:06,950 +فبيصير فيه Activation للخلية و Degranulation للـ + +69 +00:06:06,950 --> 00:06:10,830 +Inflammatory Mediators اللي موجودة فيها هذه هي + +70 +00:06:10,830 --> 00:06:18,250 +السلسلة الطبيعية للـ .. Atopy مصطلح يطلق على الناس + +71 +00:06:18,250 --> 00:06:23,750 +اللي عندهم Genetic Predisposition for localized + +72 +00:06:23,750 --> 00:06:29,670 +anaphylaxis والـ Atopic Individual في الغالب عندهم + +73 +00:06:29,670 --> 00:06:37,050 +higher level of IgE and eosinophil مصطلح + +74 +00:06:37,050 --> 00:06:40,150 +هذا بالمناسبة الـ atopic برضه ممكن يطلق على الناس + +75 +00:06:40,150 --> 00:06:43,210 +اللي عندهم genetic predisposition to induce in + +76 +00:06:43,210 --> 00:06:45,950 +hypersensitivity type one hypersensitivity + +77 +00:06:45,950 --> 00:06:50,630 +reaction الـ type one hypersensitivity reaction هو + +78 +00:06:50,630 --> 00:06:55,330 +عبارة بيتحكم في هذا الموضوع في الـ IgE production + +79 +00:06:55,330 --> 00:07:00,920 +يعني عدة جينات Polymorphic gene بما فيها IL-4 + +80 +00:07:00,920 --> 00:07:06,340 +Receptor IL-4 Cytokine Promoted Region FCY + +81 +00:07:06,340 --> 00:07:10,600 +Receptor which has high affinity or low affinity + +82 +00:07:10,600 --> 00:07:17,100 +بيعتمد للـ IgE and class II MHC molecule وطبعا هذه + +83 +00:07:17,100 --> 00:07:23,960 +بتعتبر هي المحفظة التي الـ pro-inflammatory reaction أو + +84 +00:07:23,960 --> 00:07:29,760 +الـ Inflammation gene كل هذه العوامل مجتمعة تعمل + +85 +00:07:29,760 --> 00:07:33,300 +إذا اجتمعت في شخص بيصير عنده A to B بمعنى بيصير + +86 +00:07:33,300 --> 00:07:37,780 +عنده predisposition to form type 1 + +87 +00:07:37,780 --> 00:07:46,520 +hypersensitivity reaction ما هي مرحلة الـ allergic + +88 +00:07:46,520 --> 00:07:49,520 +response في هذا النوع؟ جدول المرحلة هي الـ + +89 +00:07:49,520 --> 00:07:53,600 +sensitization Sensitization يعني أنه دخل الـ + +90 +00:07:53,600 --> 00:08:00,500 +Allergy المحفظة زي ما قلت لكم تلقفته الـ Antigen + +91 +00:08:00,500 --> 00:08:03,920 +Presenting Cell قدمته لـ T Cell الـ T Helper طبعا + +92 +00:08:03,920 --> 00:08:08,140 +والـ T Helper 2 نشطت لـ B Lymphocyte طلعت IgE + +93 +00:08:08,140 --> 00:08:11,640 +Antibody الـ IgE Antibody جاعد على سطح الـ mast سيل + +94 +00:08:11,640 --> 00:08:14,360 +والبيزوفيل هذا بيسموها Sensitized Cell + +95 +00:08:14,360 --> 00:08:20,960 +وSensitization للشخص اللي صار عنده هذا التفاعل طبعا + +96 +00:08:20,960 --> 00:08:24,500 +تي هي الـ B Cell في هذه الحالة تحتاج الـ IL 4 which is + +97 +00:08:24,500 --> 00:08:28,440 +secreted + +98 +00:08:28,440 --> 00:08:30,460 +from تي هي الـ B Cell + +99 +00:08:36,620 --> 00:08:43,020 +هذه هي تغيير الـ B Cell interaction تغيير الـ B + +100 +00:08:43,020 --> 00:08:49,020 +Cell interaction تغيير الـ B Cell interaction + +101 +00:08:49,020 --> 00:08:52,020 +تغيير الـ B Cell interaction تغيير الـ B Cell + +102 +00:08:52,020 --> 00:08:55,240 +interaction تغيير الـ B Cell interaction تغيير + +103 +00:08:55,240 --> 00:08:56,300 +الـ B Cell interaction تغيير الـ B Cell + +104 +00:08:56,300 --> 00:08:57,380 +interaction تغيير الـ B Cell interaction تغيير + +105 +00:08:57,380 --> 00:09:04,600 +الـ B Cell interaction تغيير الـ B Cell + +106 +00:09:04,600 --> 00:09:06,650 +interaction تغيير الـ B Cell بيصير فيه activation + +107 +00:09:06,650 --> 00:09:10,990 +للخلية وبيصير فيه mediator released اللي هي دي هي + +108 +00:09:10,990 --> 00:09:16,030 +الهيستامين ليكوترين الـ cytokine وطبعا في التأثير هذه + +109 +00:09:16,030 --> 00:09:19,510 +الـ mediator إما early response وإما late response + +110 +00:09:19,510 --> 00:09:21,630 +وعندنا بنحكي في هذا الموضوع + +111 +00:09:25,480 --> 00:09:29,640 +الـ IgE يمكن أن يتواصل إلى مصطلق البيزوفيل من خلال + +112 +00:09:29,640 --> 00:09:33,020 +الـ Fc Portion بيظل الـ Fab هو اللي فالت الـ half + +113 +00:09:33,020 --> 00:09:37,180 +-life of IgE في السيرم هي عبارة عن days بينما لما + +114 +00:09:37,180 --> 00:09:43,860 +بيرتبط بالـ Fc Receptor تبعه it will increase to + +115 +00:09:43,860 --> 00:09:49,220 +months Fc Epsilon Receptor it has high affinity to + +116 +00:09:49,220 --> 00:09:52,660 +IgE receptor موجود على سطح الـ mast سيل والبيزوفيل + +117 +00:09:52,660 --> 00:09:58,230 +unactivated زينوفيل الـ Allergen binding to IgE + +118 +00:09:58,230 --> 00:10:02,410 +attached to FCY receptor triggers the release of + +119 +00:10:02,410 --> 00:10:07,650 +granules from the cell يعني أول ما أثبت الـ + +120 +00:10:07,650 --> 00:10:11,310 +Allergen بالرسيبتورز هو اللي بيعمل degranulation + +121 +00:10:11,310 --> 00:10:16,690 +للمـاست سيل والبيزوفيل Upon secondary exposure to the + +122 +00:10:16,690 --> 00:10:20,950 +allergen بيصير فيه ميكانيزم للستاج التانية وهي الـ + +123 +00:10:20,950 --> 00:10:26,160 +activation الـ activation بتاعي لأن الـ mast سيل are + +124 +00:10:26,160 --> 00:10:31,020 +لبرايمد مع الـ cell لبرايمد + +125 +00:10:31,020 --> 00:10:35,780 +يعني with IgE on their surfaces ماشي لما برتبته + +126 +00:10:35,780 --> 00:10:40,180 +بالـ allergen بيصير cross-link it will activate + +127 +00:10:40,180 --> 00:10:43,580 +signal to tyrosine phosphorylation في calcium + +128 +00:10:43,580 --> 00:10:46,480 +influx في degradation and release of mediator + +129 +00:10:50,500 --> 00:10:56,600 +هذا الـ antigen أول اكتشاف تلمفوسايت نشط بالـ lymphocyte + +130 +00:10:56,600 --> 00:11:01,200 +كوان IgE جالس على سطح المعصّل أول اكتشاف ثانوية + +131 +00:11:01,200 --> 00:11:05,680 +ارتبط بالـ antibody وصار في cross-linking وصار في + +132 +00:11:05,680 --> 00:11:09,280 +activation و degranulation وطلع ليش الـ inflammatory + +133 +00:11:09,280 --> 00:11:13,900 +mediators وهذا تأثير الـ inflammatory mediators هذا + +134 +00:11:13,900 --> 00:11:19,560 +طبعا قد تؤدي إلى الـ anaphylactic shock طبعا هيوفازو + +135 +00:11:19,560 --> 00:11:24,510 +داليشين acute inflammation tissue damage muscle + +136 +00:11:24,510 --> 00:11:28,650 +contraction and bronchoconstriction Inflammatory + +137 +00:11:28,650 --> 00:11:36,050 +mediators في منها mediators زي سموها preformed + +138 +00:11:36,050 --> 00:11:42,090 +preformed mediator وفي اللي هو newly synthesized + +139 +00:11:42,090 --> 00:11:47,450 +mediator طبعا الـ preformed جاهزة بتكون مشك يعني + +140 +00:11:47,450 --> 00:11:51,820 +صنعه جاهزة في نفس الـ الماست سيل اللي هو الـ بيزوفيل وهي + +141 +00:11:51,820 --> 00:11:56,280 +اللي بتعمل الـ first response بينما اللي أو الـ + +142 +00:11:56,280 --> 00:12:01,440 +immediate reaction يعني بينما الـ late phase هو الـ + +143 +00:12:01,440 --> 00:12:11,300 +ناتج عن الـ mediators اللي اتصنعت upon activation + +144 +00:12:11,300 --> 00:12:15,440 +وطبعا + +145 +00:12:15,440 --> 00:12:18,480 +هي إن اللي هو + +146 +00:12:21,820 --> 00:12:27,640 +الـ Principal Mediators زي الهيستامين، الهيبارين، السيروتونين + +147 +00:12:27,640 --> 00:12:31,200 +وهي تأثيرها increase vascular permeability و + +148 +00:12:31,200 --> 00:12:36,700 +smooth muscle contraction هي الـ primary mediators + +149 +00:12:36,700 --> 00:12:42,600 +وفي ناس في كتب بتسميها preformed mediators وفي + +150 +00:12:42,600 --> 00:12:48,020 +اللي هو الـ secondary mediators اللي تحت وبرضه هذه + +151 +00:12:48,690 --> 00:12:57,130 +بتعمل الـ late response for this reaction هي الـ + +152 +00:12:57,130 --> 00:13:05,570 +leukotriene، prostaglandin و IL-4 و IL-13، الهيستامين + +153 +00:13:05,570 --> 00:13:10,930 +الهيستامين + +154 +00:13:10,930 --> 00:13:17,620 +بيعمل constriction of smooth muscle و بيعمل/بعمل + +155 +00:13:17,620 --> 00:13:21,340 +constriction وبالتالي بيصير في wheezing التصفيرة مع + +156 +00:13:21,340 --> 00:13:26,280 +النفس، بعمل constriction of the intestine وبالتالي + +157 +00:13:26,280 --> 00:13:30,640 +بعمل cramp وديارية، بعمل vasodilation وزيادة increase + +158 +00:13:30,640 --> 00:13:38,640 +fluid يعني ادمة، وactivate enzyme for tissue tissue + +159 +00:13:38,640 --> 00:13:42,340 +اللي هو breakdown + +160 +00:13:43,840 --> 00:13:48,760 +الليوكوترين والبروستاجلاندين، السايكلوكسيجينيز، الليوكوترين برضه هو + +161 +00:13:48,760 --> 00:13:56,100 +عبارة عن pain inducer، البروستاجلاندين له لعب دور + +162 +00:13:56,100 --> 00:14:03,500 +كبير فيه اللي هو الـ clot formation و inhibition + +163 +00:14:03,500 --> 00:14:09,960 +of clot formation هاي + +164 +00:14:09,960 --> 00:14:15,100 +الـ primary early mediators، و هذه الـ Rate Mediator + +165 +00:14:15,100 --> 00:14:19,820 +شوفوا كيف نفخت، صار في إيدينا ونفخت، هذه الـ + +166 +00:14:19,820 --> 00:14:25,700 +immediate effect of long airflow صار في wheezing + +167 +00:14:25,700 --> 00:14:30,640 +وهي الـ Late هي + +168 +00:14:30,640 --> 00:14:33,080 +preformed mediator in granules + +169 +00:14:37,610 --> 00:14:41,750 +الهيستامين، السايتوكاين، السيروتونين، كروس فاكتور ألفا، IL-1 + +170 +00:14:41,750 --> 00:14:45,950 +IL-6، كيمو أتراكتانت للنيوتروفيل والإيوزينوفيل، انزيم + +171 +00:14:45,950 --> 00:14:52,590 +زي التريبتيز والكايميز والكيبسينز، وthese changes + +172 +00:14:52,590 --> 00:14:55,490 +in connective tissue matrix وبعملوا tissue + +173 +00:14:55,490 --> 00:15:00,670 +breakdown، ليكوترين اللي هو secondary mediators + +174 +00:15:00,670 --> 00:15:04,990 +البروستاجلاندين والليوكوترين وكل السايتوكاين + +175 +00:15:07,740 --> 00:15:12,440 +بالتالي، تتجمد تجارب التنسيق والمضمون يتحكم على + +176 +00:15:12,440 --> 00:15:14,780 +الاتصال الاجتماعي الاجتماعي الاجتماعي الاجتماعي + +177 +00:15:14,780 --> 00:15:21,860 +الاجتماعي الاجتماعي الاجتماعي الاجتماعي الاجتماعي + +178 +00:15:21,860 --> 00:15:27,360 +الاجتماعي الاجتماعي الاجتماعي الاجتماعي الاجتماعي + +179 +00:15:27,360 --> 00:15:27,640 +الاجتماعي الاجتماعي الاجتماعي الاجتماعي الاجتماعي + +180 +00:15:27,640 --> 00:15:27,680 +الاجتماعي الاجتماعي الاجتماعي الاجتماعي الاجتماعي + +181 +00:15:27,680 --> 00:15:32,400 +الاجتماعي الاجتماعي الاجتما + +182 +00:15:33,690 --> 00:15:38,110 +الأولى كانت تدخل من خلال مصدر الميزوفيل والإيوزينوفيل + +183 +00:15:38,110 --> 00:15:48,850 +استعمل الإيوزينوفيل + +184 +00:15:48,850 --> 00:15:57,150 +لإيوزينوفيل + +185 +00:15:57,760 --> 00:16:02,200 +السيطوكاين والميدياتور + +186 +00:16:02,200 --> 00:16:08,140 +الليوكوترين بأنواعها، البليتليت اكتيفت، والإيوزينوفيل + +187 +00:16:08,140 --> 00:16:13,020 +بإمكانه إعطاء CD4 للجين و 4 بيليمفوسايت اكتيفت + +188 +00:16:13,020 --> 00:16:18,400 +في + +189 +00:16:18,400 --> 00:16:23,900 +معين من الـ reaction، في localized وفي systemic الـ + +190 +00:16:23,900 --> 00:16:27,770 +localized: Target organ responds to direct contact + +191 +00:16:27,770 --> 00:16:32,750 +with allergen، فلو كان في الـ GIT بيصير فيه vomiting + +192 +00:16:32,750 --> 00:16:38,590 +و cramping و diarrhea، ولو كان في الـ skin بيصير فيه + +193 +00:16:38,590 --> 00:16:43,750 +rendered inflamed area مع itching ولو كان في + +194 +00:16:43,750 --> 00:16:46,490 +الجهاز التنفسي الـ respiratory tract بيصير فيه + +195 +00:16:46,490 --> 00:16:51,350 +airway sensitivity بيتأدي إلى sneezing و rhinitis + +196 +00:16:51,350 --> 00:16:59,240 +أو wheezing وأزمة، Systemic بيحصل فيه Vasodilatation + +197 +00:16:59,240 --> 00:17:02,580 +و Muscle Contraction، هذا بيؤدي إلى Bronchial + +198 +00:17:02,580 --> 00:17:06,560 +Constriction edema and shock، هذا هو الـ Anaphylactic + +199 +00:17:06,560 --> 00:17:10,500 +shock الحقيقي، طبعا similar to systemic + +200 +00:17:10,500 --> 00:17:17,020 +inflammation treatment بيأتوا pharmacology بيأتوا + +201 +00:17:17,020 --> 00:17:21,400 +drugs non-steroidal anti-inflammatory اللي هو + +202 +00:17:21,400 --> 00:17:22,520 +الكورتيكوستيرويد + +203 +00:17:24,650 --> 00:17:28,070 +اللي هو الـ Non-steroidal بأنواعها ثم + +204 +00:17:28,070 --> 00:17:31,810 +Antihistamines to block the histamine receptor + +205 +00:17:31,810 --> 00:17:37,610 +وSteroid الكورتيكوستيرويد وTheophylline أو + +206 +00:17:37,610 --> 00:17:42,270 +Aminophylline أو Epinephrine which prolong increased + +207 +00:17:42,270 --> 00:17:47,630 +cyclic AMP وطبعاً هذا بعمل inhibition ليش لديه + +208 +00:17:47,630 --> 00:17:51,510 +Granulation، اليوم بيعملوا Hyposensitization + +209 +00:17:51,510 --> 00:17:53,050 +بيعتبروها immunotherapy + +210 +00:18:10,800 --> 00:18:15,140 +الحاجة الأولانية اما بعمل shifting from Th2 to + +211 +00:18:15,140 --> 00:18:20,060 +Th1 أو بعمل class switching from IgE to IgG + +212 +00:18:20,060 --> 00:18:27,660 +وفي كل الحالتين نتخلص من الحساسية طبعا هي الـ shifting الـ + +213 +00:18:27,660 --> 00:18:35,160 +IgE نزلت وطلع الـ IgG بدالها، IgG ما بعملش حساسية اللي + +214 +00:18:35,160 --> 00:18:39,560 +بعمل حساسية هو الـ IgE ليش؟ لأنه الـ receptor على + +215 +00:18:39,560 --> 00:18:46,030 +المستقبلات والأذرع الـ IgG مالهوش، هذا هو تجارب الـ Hypera + +216 +00:18:46,030 --> 00:18:48,050 +sensitivity الأساسية الأساسية الأساسية الأساسية + +217 +00:18:48,050 --> 00:18:50,610 +الأساسية الأساسية الأساسية الأساسية الأساسية + +218 +00:18:50,610 --> 00:18:52,070 +الأساسية الأساسية الأساسية الأساسية الأساسية + +219 +00:18:52,070 --> 00:18:52,110 +الأساسية الأساسية الأساسية الأساسية الأساسية + +220 +00:18:52,110 --> 00:18:55,790 +الأساسية الأساسية الأساسية الأساسية الأساسية + +221 +00:18:55,790 --> 00:18:55,990 +الأساسية الأساسية الأساسية الأساسية الأساسية + +222 +00:18:55,990 --> 00:18:56,850 +الأساسية الأساسية الأساسية الأساسية الأساسية + +223 +00:18:56,850 --> 00:18:58,010 +الأساسية الأساسية الأساسية الأساسية الأساسية + +224 +00:18:58,010 --> 00:19:01,460 +الأساسية الأساسية، الانتيبادي هم IgM أو IgG بكتبه + +225 +00:19:01,460 --> 00:19:04,180 +مع cell surface molecule وبيصير فيه antibody + +226 +00:19:04,180 --> 00:19:07,760 +-antibody complex، بنشط الـ complement على سطح + +227 +00:19:07,760 --> 00:19:12,120 +الخلية فبكسر الخلية، فسيصبح Hemolysis طبعا + +228 +00:19:12,120 --> 00:19:15,560 +inappropriate response في الوضع الطبيعي it + +229 +00:19:15,560 --> 00:19:19,580 +eliminate foreign cells في الوضع الطبيعي ممكن + +230 +00:19:19,580 --> 00:19:23,880 +يتكون antibody أو auto-antibody فرصة في انتيجين ويعمل + +231 +00:19:23,880 --> 00:19:29,440 +auto immunity disease وبالتالي الـ antigen الـ + +232 +00:19:29,440 --> 00:19:37,260 +antibody should be tolerated وهي الميكانيزم، الانتيجين + +233 +00:19:37,260 --> 00:19:42,740 +دخل على موجود على سطح الخلية، سوري، antibody تكون له + +234 +00:19:42,740 --> 00:19:47,600 +قوات يرتبط فيه، اما بينشط الـ complement وبيعمل + +235 +00:19:47,600 --> 00:19:51,790 +membrane attack complex وبيكسرها، وإما بعمل Antibody + +236 +00:19:51,790 --> 00:19:54,670 +Dependent Cell Mediated Cytotoxicity لأن + +237 +00:19:54,670 --> 00:19:58,410 +الانتيبادي موجود والـ Fc Portion فالد وبالتالي + +238 +00:19:58,410 --> 00:20:01,270 +يقلّ الـ Fc Portion ويجيجي يقلّ الـ Receptor على + +239 +00:20:01,270 --> 00:20:10,470 +سطح عدد كبير من الفاجوسايتكسيل والانكيسم فبتعمل + +240 +00:20:10,470 --> 00:20:15,050 +Destruction للخلية، وإما بعمل Opsonization ومحصلته + +241 +00:20:15,050 --> 00:20:18,390 +أيضا فاجوسيتوسيز، في جميع الحالات بصير Cell + +242 +00:20:18,390 --> 00:20:19,550 +Destruction + +243 +00:20:21,660 --> 00:20:27,480 +عنصر على ذلك ناخد مثال على الـ autoimmunity، مثال + +244 +00:20:27,480 --> 00:20:30,940 +المشهور اللي هو Goodpasture's syndrome هو برعنة + +245 +00:20:30,940 --> 00:20:33,420 +الانتيجين بيكون هو برعنة Alpha 3 chain of + +246 +00:20:33,420 --> 00:20:36,580 +basement membrane للكولاجين موجود على الكلى + +247 +00:20:36,580 --> 00:20:43,540 +والرئة، متكون Antibody للـ Alpha 3 اللي هو chain + +248 +00:20:43,540 --> 00:20:47,620 +basement membrane، ويوم ما يحصل cross-linking مع + +249 +00:20:47,620 --> 00:20:51,600 +الـ receptor و الـ cytotoxic cell أو على سطح الخلية + +250 +00:20:51,600 --> 00:20:55,560 +الـ cytotoxic cell بنشط monocyte و neutrophil و + +251 +00:20:55,560 --> 00:20:59,480 +mesophil، طبعا بتفرز كيموكاين which recruit more + +252 +00:20:59,480 --> 00:21:03,900 +neutrophil، وطبعا this will lead to self tissue + +253 +00:21:03,900 --> 00:21:13,860 +destruction وهي صورة الـ lung كيف صار لها + +254 +00:21:13,860 --> 00:21:20,000 +infarction، مثال آخر اللي هو for an antigen طبعا في + +255 +00:21:20,000 --> 00:21:23,960 +هذه الحالة يوم ما تنقل incompatible blood through + +256 +00:21:23,960 --> 00:21:28,760 +transfusion بيصير transfusion reaction وهي بيصير + +257 +00:21:28,760 --> 00:21:33,780 +اللي هو incompatibility، طبعا كلنا بنعرف أنه فصيلة + +258 +00:21:33,780 --> 00:21:37,640 +A عندها انتيجين B وفصيلة B عندها انتيجين A فأي خلل في نقل + +259 +00:21:37,640 --> 00:21:42,800 +أي فصيلة بيدينا اللي هو بيكون فيه strong antibody + +260 +00:21:42,800 --> 00:21:47,090 +جاهز بيستنى الـ antigen فهو IgM، فبيرتبط فيه وبيعمل + +261 +00:21:47,090 --> 00:21:53,910 +agglutination reaction، drugs أيضا ممكن يصير + +262 +00:21:53,910 --> 00:21:58,050 +في نفس الحكاية إن الـ drug يقعد على سطح يرتبط + +263 +00:21:58,050 --> 00:22:04,190 +بأنتيجينات على سطح خلايا معينة منها الـ RBCs، فطبعا + +264 +00:22:04,190 --> 00:22:08,530 +الـ drugs بيكون في الوضع الأولاني هو hapten طبعا + +265 +00:22:08,530 --> 00:22:13,890 +بيصير بيعتبر Epitopes بيعتبر Hapten لما بيقعد على + +266 +00:22:13,890 --> 00:22:18,350 +السطح الخلية بيرتبط ببروتينات في الـ membrane بيكبر + +267 +00:22:18,350 --> 00:22:21,150 +وبيصير immunogen، بتكوّله antibody اللي بيقدر + +268 +00:22:21,150 --> 00:22:27,970 +يتفاعل مع مين؟ مع الـ antigen مع الـ Hapten والـ + +269 +00:22:27,970 --> 00:22:35,960 +protein اللي ارتبط فيه، الـ ... طبعا أيضا + +270 +00:22:35,960 --> 00:22:41,020 +ممكن الـ Antibody اللي بتكون هو عبارة عن IgG، IgG + +271 +00:22:41,020 --> 00:22:45,980 +مايقدرش يعمل تكسير للـ Direct Hemolysis فبالتالي + +272 +00:22:45,980 --> 00:22:51,340 +ممكن خلية تتكسر اما Through ADCC واما Through + +273 +00:22:51,340 --> 00:22:56,960 +Phagocytosis، Drug induced thrombocytopenic purpura + +274 +00:22:56,960 --> 00:23:04,040 +برضه نفس الحكاية بتكون Antibody للـ Platelet و + +275 +00:23:04,040 --> 00:23:08,960 +Antibody للـ Platelet وبالتالي صار في Opsonized + +276 +00:23:08,960 --> 00:23:14,820 +Platelet، طبعا هذه اسمها Destruction by + +277 +00:23:14,820 --> 00:23:19,000 +Phagocytosis + +278 +00:23:19,000 --> 00:23:22,860 +Hemolytic + +279 +00:23:22,860 --> 00:23:26,380 +disease of new born، طبعا الـ Rh incompatibility كل + +280 +00:23:26,380 --> 00:23:30,950 +كتير في حدوثه أن الـ mother، Rh negative mother لما + +281 +00:23:30,950 --> 00:23:35,430 +تكون حاملة بـ RH positive baby طبعا في الـ baby + +282 +00:23:35,430 --> 00:23:39,530 +الأولاني بيعدي لكن during delivery شوية أنتيجينات + +283 +00:23:39,530 --> 00:23:43,390 +لـ RH positive بخش على الـ mother blood فبتكونله + +284 +00:23:43,390 --> 00:23:47,150 +antibody منه IGG في الـ second pregnancy it can + +285 +00:23:47,150 --> 00:23:54,810 +cross the placenta وبيهاجم الـ baby second baby هذا + +286 +00:23:54,810 --> 00:23:59,590 +هوهذه أمثلة عن الـ Hypersensitivity Type-2 + +287 +00:23:59,590 --> 00:24:05,470 +Hypersensitivity Reaction Type-3 ماذا يحصل؟ ما + +288 +00:24:05,470 --> 00:24:10,230 +يحصل في الـ Immune Complexes Immune Complexes + +289 +00:24:10,230 --> 00:24:16,070 +Formation ما يحصل؟ يتكون Antigen Antibody Reaction + +290 +00:24:16,070 --> 00:24:19,270 +بكميات كبيرة بسبب Deposition على الـTissue وهو + +291 +00:24:19,270 --> 00:24:24,370 +طبعاً هذا بنشطنا بيجي يتكلم داخل الـCell + +292 +00:24:24,370 --> 00:24:28,210 +الـPhagocytic Cell بيجي يتخلصنا منه لكن ما بتقدر + +293 +00:24:28,210 --> 00:24:33,970 +فتعمل Degranulation وTissue Damage Payer هي سوليب + +294 +00:24:33,970 --> 00:24:40,160 +الانتيجين الانتبادي IGG مع الـComplement انتجار غير + +295 +00:24:40,160 --> 00:24:43,060 +مناسب في الوضع الطبيعي الانتيجين انتجار غير مناسب + +296 +00:24:43,060 --> 00:24:45,640 +في الوضع الطبيعي الانتيجين انتجار بيساعد في + +297 +00:24:45,640 --> 00:24:49,540 +الفلوسيتوسيز وكليرانس الهيار أو الانتيجين لكن + +298 +00:24:49,540 --> 00:24:56,340 +بمجرد أن يكون هناك عدد كبير من الكمبليكسيز يحصل + +299 +00:24:56,340 --> 00:25:00,560 +فيه تشيو دامج طبعا + +300 +00:25:00,560 --> 00:25:05,430 +تابع ثلاثة بيط وسموه others reaction هي الـ + +301 +00:25:05,430 --> 00:25:10,050 +Previously Synthesized Host يمثل فيه Antigen + +302 +00:25:10,050 --> 00:25:13,670 +Exposure to Specific Site إما بإنهيليشن أو إنجيكشن + +303 +00:25:13,670 --> 00:25:19,450 +بيتكون Antibody من نوع IgG مع الانتجين فبيكون IgG + +304 +00:25:19,450 --> 00:25:24,890 +Antigen Complex طبعا هذا إما بنشط الـ complement تكون + +305 +00:25:24,890 --> 00:25:31,190 +C3A C5A دي are Anaflatoxin and Chemotactic Agent + +306 +00:25:31,190 --> 00:25:38,660 +ويعملوا Membrane Attack Complex أو أنه بتكون الـ IGG + +307 +00:25:38,660 --> 00:25:47,280 +وبيعمل ايش بيعمل optionization لليكوسايد وهي + +308 +00:25:47,280 --> 00:25:54,220 +بالتالي it will be phagocytosis or by releasing of + +309 +00:25:54,220 --> 00:26:01,780 +lytic enzyme secretion هذا + +310 +00:26:01,780 --> 00:26:07,040 +هيطبعا هي الانتيجن تكونله antibody في blood + +311 +00:26:07,040 --> 00:26:12,440 +vessels هي فصار في antibody-antibody complex + +312 +00:26:12,440 --> 00:26:19,780 +انتيجن antibody-antibody complex ممكن ينشطلنا في + +313 +00:26:19,780 --> 00:26:23,940 +agostatic cell تيجي تخلصنا منه و بتقدرش فبتعمل + +314 +00:26:23,940 --> 00:26:26,740 +degranulation في منطقة الحدث وبالتالي بيصير في + +315 +00:26:26,740 --> 00:26:28,440 +tissue damaged + +316 +00:26:32,260 --> 00:26:35,040 +Antigen-antibody-immune-complex الـ IgG-mediated + +317 +00:26:35,040 --> 00:26:39,120 +immune-complex disease كميات كبيرة من الانتيجين + +318 +00:26:39,120 --> 00:26:44,220 +والانتبادي تشكل كمبليكسات في الدم، إذا لم يتم + +319 +00:26:44,220 --> 00:26:47,980 +إيقافها، يمكن أن تدفعها إلى الورق أو الرقص ويؤثر + +320 +00:26:47,980 --> 00:26:52,720 +على الإنفلام. طبعاً هذا هي المحصلة + +321 +00:26:55,390 --> 00:26:59,690 +Antigen Antibody ده هو Immune Complex اتكون نشطت + +322 +00:26:59,690 --> 00:27:04,370 +إنها عدة خلايا الـ Platelet عملت من Micro from با + +323 +00:27:04,370 --> 00:27:09,590 +عي بيزوفيل نشطته عملت Vasoactive Amine وبالتالي + +324 +00:27:09,590 --> 00:27:14,990 +عملت Vasodilator وAedema الـ complement في إنها C3A + +325 +00:27:14,990 --> 00:27:22,430 +C5A بتتكون وهي عبارة عن Chemotactic Factor + +326 +00:27:22,430 --> 00:27:27,770 +وفي نفس الوجود أنا أعرف لها Toxin طبعا هي الـ C5A + +327 +00:27:27,770 --> 00:27:30,850 +نشطة الـنيوتروفيل فهي جت تخلصنا من الـ complex + +328 +00:27:30,850 --> 00:27:34,410 +بتقدرش فبتعمل Degranulation بيسموها frustrated + +329 +00:27:34,410 --> 00:27:39,430 +phagocytosis ليش؟ مفروض تاكل فماقدرتش تاكل فعملت + +330 +00:27:39,430 --> 00:27:44,170 +digestion outside the cell وبيسموها اللي هو + +331 +00:27:44,170 --> 00:27:49,530 +frustrated phagocytosis طبعا + +332 +00:27:51,390 --> 00:27:55,830 +أو الـ Granule Contents عندما يخرج من الخلية يعمل + +333 +00:27:55,830 --> 00:28:01,010 +تشيو دامج هذا + +334 +00:28:01,010 --> 00:28:06,090 +هو كما تشاهدون هنا يوجد Immune Complex هنا طبعا + +335 +00:28:06,090 --> 00:28:09,250 +الـ Immune Complex نشطت نشطت نيوتروفيل يأتي تخلصنا + +336 +00:28:09,250 --> 00:28:15,270 +منها ولا تريدها فتعمل تشيو دامج تعمل تشيو دامج + +337 +00:28:15,270 --> 00:28:18,350 +cell membrane damage + +338 +00:28:20,580 --> 00:28:27,240 +نفس الحكاية بتعمل Vasculitis هذا في حالات اللي هو + +339 +00:28:27,240 --> 00:28:30,560 +الـ autoimmune أو الـ immune complex mediated tissue + +340 +00:28:30,560 --> 00:28:35,460 +injury type 3 immune complex polymorphic nuclear + +341 +00:28:35,460 --> 00:28:39,720 +and macrophage bind to immune complexes via FC + +342 +00:28:39,720 --> 00:28:43,140 +receptor and phagocytase the complex لكن إذا + +343 +00:28:43,140 --> 00:28:50,800 +ماقدرتش وبالتالي يمكن أن يسبب انفلامية من خلال + +344 +00:28:50,800 --> 00:28:58,240 +اكتتاب complement بطلعة C3A C4A C5A ويتعمل فرسترات + +345 +00:28:58,240 --> 00:29:02,860 +فاقوسييتز فرسترات فاقوسييتز هي كيفينيوتر فيها + +346 +00:29:02,860 --> 00:29:06,600 +ماكروفيش ممكن أن يفرسترات فاقوسييتز + +347 +00:29:09,500 --> 00:29:12,080 +هو الـ Degranulate in the area of immune complex + +348 +00:29:12,080 --> 00:29:15,600 +deposition and trigger inflammation يعني أنا + +349 +00:29:15,600 --> 00:29:22,460 +unable to eat فتحاول تدخل خارج الجسم مثال + +350 +00:29:22,460 --> 00:29:30,200 +حقيقي برضه على اللي هو الـ localized + +351 +00:29:32,130 --> 00:29:36,330 +الخاصة التالية بتسمى + +352 +00:29:36,330 --> 00:29:41,570 +Extrinsic Allergic Alveolitis هو بيصيب الـfarmers + +353 +00:29:41,570 --> 00:29:48,270 +لنجه هدى يدخلوا فيها مفلك أكتينوموائيسيد موجودة في + +354 +00:29:48,270 --> 00:29:53,750 +الـdry and dusty moldy hay بيساولها inhalation by + +355 +00:29:53,750 --> 00:29:57,570 +large amount طبعا الـ initial exposure بده يعمل + +356 +00:29:57,570 --> 00:30:02,000 +يكون أن IGG antibody about repeated exposure الـ + +357 +00:30:02,000 --> 00:30:06,820 +Antibody موجود وطبعا يحصل فيه Immune Complexes في + +358 +00:30:06,820 --> 00:30:13,620 +اللغة و Pneumonitis و Alveolitis Generalized + +359 +00:30:13,620 --> 00:30:18,900 +reaction هي Systemic Exposure to Antigen كون Large + +360 +00:30:18,900 --> 00:30:24,700 +amount of IgG Small IgG مع الانتجين Complexes + +361 +00:30:24,700 --> 00:30:28,460 +Difficult to clear circulate and become deposited + +362 +00:30:28,460 --> 00:30:38,030 +all over the body طبعا تصبح تشيو دمج بسبب اكتفيش + +363 +00:30:38,030 --> 00:30:41,950 +فجوسيتكسل + +364 +00:30:41,950 --> 00:30:46,970 +هاي مثال آخر Serum Sickness طبعا أنا انترالينس أو + +365 +00:30:46,970 --> 00:30:50,450 +انترالينس أو انترالينس أو انترالينس أو انترالينس + +366 +00:30:56,350 --> 00:31:00,570 +سم حققناه في حصان أخدنا بعد هيكا الـ serum تبع + +367 +00:31:00,570 --> 00:31:04,530 +الحصان وطلعنا الـ antibody تبعه هذا ممكن يكون ك + +368 +00:31:04,530 --> 00:31:14,410 +vaccine طبعا يوم ما أبقى يوم + +369 +00:31:14,410 --> 00:31:18,890 +ما ناخده ونحقنه في إنسان طبعا هذا ممكن الإنسان + +370 +00:31:18,890 --> 00:31:23,710 +طبعا اللي ماخد الـ venom هيصير في Immune Complexes + +371 +00:31:23,710 --> 00:31:28,280 +وهتترسب على الـ joint و skin و kidney و تعمل مشاكل + +372 +00:31:28,280 --> 00:31:33,720 +هاي الـ serum sickness هاي الـ free antigen في الأول + +373 +00:31:33,720 --> 00:31:40,280 +بعد ذلك طبعا صار في Immune Complexes وهي الـ + +374 +00:31:40,280 --> 00:31:44,800 +symptoms وبدت تتكون large amount of antigen such + +375 +00:31:44,800 --> 00:31:46,960 +as injection و free serum + +376 +00:31:51,290 --> 00:31:56,630 +لوكاليز ديزييت ترسّب الـ Immune Complexes على الـ joint + +377 +00:31:56,630 --> 00:32:00,470 +بيعمل Inflammation و arthritis وعلى الـ kidney بيعمل + +378 +00:32:00,470 --> 00:32:05,980 +Glomerulonephritis Auto immunity مثال آخر SLE + +379 +00:32:05,980 --> 00:32:10,480 +Systemic Leukocytic Rheumatosis في اللي بيصير طارد + +380 +00:32:10,480 --> 00:32:15,380 +الإنسان للشمس Ultraviolet light أو cell death وهي + +381 +00:32:15,380 --> 00:32:21,660 +بيصير في Impaired apoptic cell clearance لأن هذا + +382 +00:32:21,660 --> 00:32:24,680 +بيؤدي إلى Nuclear chromatin مع DNA exposed to the + +383 +00:32:24,680 --> 00:32:31,420 +circulation طبعا Auto antibody بتكون لهم الـ B-cell + +384 +00:32:31,420 --> 00:32:36,920 +priming زي الـ class switching to IgG هيعمل .. + +385 +00:32:36,920 --> 00:32:40,580 +هيرتبط معاياش مع الـ Antigen ويعمل Immune + +386 +00:32:40,580 --> 00:32:47,160 +Complexes هي نفس الحكاية Circulating B lymphocyte + +387 +00:32:47,160 --> 00:32:54,220 +بترتبط بطبيعياش بـ Antigen ماشي أخدت قدمته لـ T + +388 +00:32:54,220 --> 00:32:58,680 +lymphocyte نشطتها كونت Antibody الـ Antibody ارتبط + +389 +00:32:58,680 --> 00:33:02,400 +في اللي هيش الـ Antigen كون Immune Complexes إجت + +390 +00:33:02,400 --> 00:33:11,980 +الفاجوسة تكسل وطبعا ماقدرتش تخلصنا منه فبيصير فيه + +391 +00:33:11,980 --> 00:33:19,580 +Deposition و Injury at site of infection وحصلة + +392 +00:33:19,580 --> 00:33:25,480 +tissue damage type 4 hypersensitivity reaction هو + +393 +00:33:25,480 --> 00:33:30,120 +الـ Delayed type hypersensitivity reaction وهذا + +394 +00:33:30,120 --> 00:33:35,060 +يتمثل بتنشيط T helper واحد مع cytotoxic CD8-T + +395 +00:33:35,060 --> 00:33:39,840 +lymphocyte الـ Cytokine اللي بطلع من T helper واحد + +396 +00:33:39,840 --> 00:33:44,160 +بنشطلنا الماكرافيج والماكرافيج بتعمل Delayed type + +397 +00:33:44,160 --> 00:33:49,390 +hypersensitivity reaction T برواحة cell release + +398 +00:33:49,390 --> 00:33:53,690 +Cytokine to activate macrophage بيعمل Inflammation + +399 +00:33:53,690 --> 00:33:57,830 +and tissue damage Continued macrophage activation + +400 +00:33:57,830 --> 00:34:02,010 +بيؤدي لـ chronic inflammation وهذا بيؤدي لـ tissue + +401 +00:34:02,010 --> 00:34:08,110 +lesion و scarring و granuloma الـ reaction ممكن + +402 +00:34:08,110 --> 00:34:12,350 +يكون Delayed because Delayed type hypersensitivity + +403 +00:34:12,350 --> 00:34:19,670 +response بيوصل طبعا الـ reaction حدوثه بعد 24 إلى 72 + +404 +00:34:19,670 --> 00:34:26,430 +ساعة after exposure rather than minutes يعني + +405 +00:34:26,430 --> 00:34:30,950 +التفارق بيحصل بعد 24 إلى 72 ساعة player T helper + +406 +00:34:30,950 --> 00:34:35,130 +one macrophage normally necessary immune + +407 +00:34:35,130 --> 00:34:39,710 +protection against intracellular pathogen لكن if + +408 +00:34:39,710 --> 00:34:42,090 +prolonged response lead to extensive tissue + +409 +00:34:42,090 --> 00:34:47,860 +destruction مرضه بيتمثل بأكثر من Stage أول Stage + +410 +00:34:47,860 --> 00:34:51,700 +اللي هو Sensitization ايش اللي بيصير؟ والله يتيهي + +411 +00:34:51,700 --> 00:34:54,040 +البرامو .. مين مولي تيهي البراسيل؟ يعني ايش؟ يعني + +412 +00:34:54,040 --> 00:34:58,580 +شافت الـ antigen قبل هيك طب ايش بتعمل؟ قالوا + +413 +00:34:58,580 --> 00:35:03,120 +against Delayed type hypersensitivity antigen اه + +414 +00:35:03,120 --> 00:35:08,480 +Renated شو اللي خلاها الست اتنشط بـ Identity Cell + +415 +00:35:08,480 --> 00:35:12,140 +during Sensitization Stage العزيزة الـ T-Helper + +416 +00:35:12,140 --> 00:35:14,260 +cell can activate macrophage and trigger + +417 +00:35:14,260 --> 00:35:19,280 +inflammatory response ايوه first exposure انتجين + +418 +00:35:19,280 --> 00:35:27,200 +presenting cell أخدت الانتجين قدمته مرتبط بالـ MHC + +419 +00:35:27,200 --> 00:35:32,620 +-molecule لـ T cell اللي هو CD4 T-Helper cell طبعا + +420 +00:35:32,620 --> 00:35:37,860 +في هذه الحالة صار مشتقت وادتني T-Helper واحد + +421 +00:35:39,560 --> 00:35:45,640 +تقريبا 1 تقريبا 1 تقريبا + +422 +00:35:45,640 --> 00:35:51,320 +1 + +423 +00:35:51,320 --> 00:35:53,120 +تقريبا 1 تقريبا 1 تقريبا 1 تقريبا 1 تقريبا 1 + +424 +00:35:53,120 --> 00:35:53,240 +تقريبا 1 تقريبا 1 تقريبا 1 تقريبا 1 تقريبا 1 + +425 +00:35:53,240 --> 00:35:53,760 +تقريبا 1 تقريبا 1 تقريبا 1 تقريبا 1 تقريبا 1 + +426 +00:35:53,760 --> 00:35:54,440 +تقريبا 1 تقريبا 1 تقريبا 1 تقريبا 1 تقريبا 1 + +427 +00:35:54,440 --> 00:36:03,600 +تقريبا 1 تقريبا 1 تقريبا 1 تقريبا 1 تق + +428 +00:36:05,250 --> 00:36:13,450 +سيكون عارف و الـT helper والـ memory مستعملة تفرش + +429 +00:36:13,450 --> 00:36:16,650 +الـسايتوكاين ذاتي الجامعة الـ interferon الـ gamma الـ TNF alpha + +430 +00:36:16,650 --> 00:36:23,690 +فاكتور ألفا وبيتا وتعمل تشويه دمج وإنفلاميشن ال + +431 +00:36:23,690 --> 00:36:27,570 +IL2 أيضا يستعمل تشويه سايتوكسيك الـ T helper والـ + +432 +00:36:27,570 --> 00:36:34,490 +بالإضافة الـ T helper والـ chemokine 4 مايكروفاج مستعملة + +433 +00:36:35,910 --> 00:36:38,550 +العيال التلاتة GMC-SF يمكن أن تزداد مايكروفاج مونو + +434 +00:36:38,550 --> 00:36:40,470 +سايت مايكروفاج مايكروفاج مايكروفاج مايكروفاج مايكروفاج + +435 +00:36:40,470 --> 00:36:41,530 +مايكروفاج مايكروفاج مايكروفاج مايكروفاج مايكروفاج + +436 +00:36:41,530 --> 00:36:44,650 +مايكروفاج مايكروفاج مايكروفاج مايكروفاج مايكروفاج + +437 +00:36:44,650 --> 00:36:45,670 +مايكروفاج مايكروفاج مايكروفاج مايكروفاج مايكروفاج + +438 +00:36:45,670 --> 00:36:45,690 +مايكروفاج مايكروفاج مايكروفاج مايكروفاج مايكروفاج + +439 +00:36:45,690 --> 00:36:52,590 +مايكروفاج مايكروفاج مايكروفاج مايكروفاج مايكروفاج + +440 +00:36:52,590 --> 00:36:56,450 +مايكروفاج + +441 +00:36:56,450 --> 00:37:03,330 +ميكرو + +442 +00:37:05,470 --> 00:37:10,350 +أي ساكند اكسبوجر من موري تير برسيل حتى ولا افكتور + +443 +00:37:10,350 --> 00:37:13,590 +تير برسيل with specific cytokine, inflammatory + +444 +00:37:13,590 --> 00:37:19,330 +cytokine, chemokine for phagocytes recruitment شرة + +445 +00:37:19,330 --> 00:37:23,290 +الجامعة انترفيرون more activated macrophage to + +446 +00:37:23,290 --> 00:37:27,210 +exposure sites at exposure sites mostly non + +447 +00:37:27,210 --> 00:37:31,710 +-specific inflammatory cell زي الـ macrophage و + +448 +00:37:31,710 --> 00:37:36,050 +few antigen specific cell زي الـ T lymphocytes are + +449 +00:37:36,050 --> 00:37:40,030 +present هي + +450 +00:37:40,030 --> 00:37:46,930 +الـ T البربونة ستت لنا الـ macrophage طبعا هذا يوم + +451 +00:37:46,930 --> 00:37:51,190 +يحصل في chronic activation للميكروفاج تعمل ما يسمى + +452 +00:37:51,190 --> 00:37:56,900 +بالـ granuloma اللي هوFormation أيها مليانة بـ + +453 +00:37:56,900 --> 00:38:03,660 +macrophage محاطة بـ T-cell بكتيريا لا يمكن ان تكون + +454 +00:38:03,660 --> 00:38:10,020 +اختلطت تكون فلورا جرانيولوما Formation وهي طبعا في + +455 +00:38:10,020 --> 00:38:14,960 +continuous macrophage ذاتي البروان اكتفيشن بس هذا + +456 +00:38:14,960 --> 00:38:19,560 +بيقدي الهيلتك انزيم و tissue damage اي جرانيولوما + +457 +00:38:19,560 --> 00:38:20,920 +Formation + +458 +00:38:24,330 --> 00:38:28,590 +كمتك درماتيتس طبعا مثال آخر من أمثلة delayed type + +459 +00:38:28,590 --> 00:38:34,130 +hypersensitivity طبعا هذا في عدة أمثلة منها المثال + +460 +00:38:34,130 --> 00:38:41,890 +الأول هو poison أويج هو عبارة عن classic type شو + +461 +00:38:41,890 --> 00:38:45,650 +اللي بيصير طبعا هذا ال poison موجود على أوراق بعض + +462 +00:38:45,650 --> 00:38:53,140 +النباتات على شكل oil يوم ما حد يمسكهطبعاً بيصيله + +463 +00:38:53,140 --> 00:38:57,140 +absorption by skin تتلقى في antigen-presenting + +464 +00:38:57,140 --> 00:39:00,740 +cell و بتقدمه للـT helper واحد و بتعمل sensitization + +465 +00:39:00,740 --> 00:39:06,580 +upon secondary explosion الـ T helper واحد memory cell + +466 +00:39:06,580 --> 00:39:11,780 +بتنشط و بتعمل delayed type hypersensitivity هى ده + +467 +00:39:11,780 --> 00:39:19,700 +هى هى النباتات هى ال poison هى فيه toxicodendron + +468 +00:39:19,700 --> 00:39:27,470 +materialبنتا ديكا كاتيكول substance تحتوي على هذه + +469 +00:39:27,470 --> 00:39:31,410 +المادة بتخش can be absorbed تتلقفها تجيب + +470 +00:39:31,410 --> 00:39:35,050 +presenting cell تقدمها لـ T lymphocyte اللي بتبدأ + +471 +00:39:35,050 --> 00:39:41,730 +تفرز هذا هي cytokine بتنشط اللي هو الـ macro phase + +472 +00:39:41,730 --> 00:39:48,770 +وطبعا بيصير فيه tissue damageمثلًا آخر اللي هو الـ + +473 +00:39:48,770 --> 00:39:51,430 +small molecules اللي موجودة في اللواعي الداخلية زي + +474 +00:39:51,430 --> 00:39:56,050 +النكل والكروم أيضًا can act as a haptin الجسم + +475 +00:39:56,050 --> 00:39:59,850 +بيمطسها ترتبط ببروتينات الجسم من داخلها وبتصير + +476 +00:39:59,850 --> 00:40:02,350 +immunogen بتتلقى في antigen presenting cell + +477 +00:40:02,350 --> 00:40:06,230 +وبتقدمها لـ T cell طبعًا الـ T cell هتتنشط ي البروان + +478 +00:40:06,230 --> 00:40:11,530 +تتنشط وتنشط لنا الـ macro phase اللي هتعمل اللي هو + +479 +00:40:11,530 --> 00:40:16,530 +tissue damage الـ lips الـ gloves + +480 +00:40:17,560 --> 00:40:21,600 +لفظ اللي مليانة باودر نفس الحكاية الباودر can be + +481 +00:40:21,600 --> 00:40:25,840 +absorbed by skin و بيخش على شكل هابتين برتبط + +482 +00:40:25,840 --> 00:40:31,000 +بالبروتينات تحور إليها immunogen بنشط طبعا تاخدوا + +483 +00:40:31,000 --> 00:40:34,040 +antigen presenting cell و بنشطتيه البروان اللي + +484 +00:40:34,040 --> 00:40:36,340 +بتنشط microphage و بتعمل tissue damage + +485 +00:40:39,270 --> 00:40:43,190 +أيضا مثال آخر الـ Mantoux test أو الـ Mycobacterial + +486 +00:40:43,190 --> 00:40:46,650 +tuberculosis طبعا هذا purified protein derivative + +487 +00:40:46,650 --> 00:40:49,810 +بيحقن تحت الجلد و بنستنى عليه اربع و عشرين ساعة + +488 +00:40:49,810 --> 00:40:52,530 +ثمانى و اربعين ساعة اتمانى اربعين اتنين و سبعين + +489 +00:40:52,530 --> 00:40:57,450 +sorry ساعة و بنشوف اذا كان صار wheel and flare + +490 +00:40:57,450 --> 00:41:00,670 +reaction او بيسموه swelling سهل تشوف اذا في + +491 +00:41:00,670 --> 00:41:03,350 +swelling معناته في previous exposure مافيش + +492 +00:41:03,350 --> 00:41:08,840 +swelling معناته مافيش previous exposureطبعا هذه + +493 +00:41:08,840 --> 00:41:14,300 +الأمثلة عن الـDelayed Type Hypersensitivity كلها + +494 +00:41:14,300 --> 00:41:18,960 +وشو بتعمل Clinical Sign وHistological Feature هذه + +495 +00:41:18,960 --> 00:41:24,620 +طبعا نشرة عن الـDelayed Type Hypersensitivity + +496 +00:41:24,620 --> 00:41:31,380 +وملاقتها بتجه البروان هذه الأربع أنواع ملخصين وكل + +497 +00:41:31,380 --> 00:41:35,180 +نوع مين بتنشط فيه وإيش ال clinical manifestation + +498 +00:41:35,180 --> 00:41:41,880 +اللي بتصير أثناءهوبهيك بنكون خلصنا أول section من + +499 +00:41:41,880 --> 00:41:45,000 +هذه المحاضرة وهو Hypersensitivity diff --git a/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/PUixi-Psy3Y_postprocess.srt b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/PUixi-Psy3Y_postprocess.srt new file mode 100644 index 0000000000000000000000000000000000000000..a986a206b10178fd2a16a804f3e42413b23bef37 --- /dev/null +++ b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/PUixi-Psy3Y_postprocess.srt @@ -0,0 +1,1996 @@ +1 +00:00:02,530 --> 00:00:07,590 +بسم الله الرحمن الرحيم وصلنا + +2 +00:00:07,590 --> 00:00:12,330 +الان الى ال immunoclinical immunology او clinical + +3 +00:00:12,330 --> 00:00:19,850 +immunology part و هنبدأ بال immunopathology و ال + +4 +00:00:19,850 --> 00:00:27,150 +disorders of immune response و يقسموها الى تلت + +5 +00:00:27,150 --> 00:00:32,200 +أنواع أساسيةجالو اما exaggerated يعني over + +6 +00:00:32,200 --> 00:00:35,580 +reactive in your response وبتتمثل + +7 +00:00:35,580 --> 00:00:42,660 +بالhypersensitivity reaction واما deficient وطبعا + +8 +00:00:43,920 --> 00:00:49,740 +المثال عليها immunodeficiency or misdirected وطبعا + +9 +00:00:49,740 --> 00:00:54,640 +هذا هنحكي في ال autoimmune disease هنبدأ في أول + +10 +00:00:54,640 --> 00:00:58,060 +معنى هو ال hypersensitivity reaction وطبعا هذا + +11 +00:00:58,060 --> 00:01:02,240 +الجدول بيبين أن الأربع أنواع مختلفة من ال + +12 +00:01:02,240 --> 00:01:06,100 +hypersensitivity reaction وإذا بتلاحظوا أول تلاتة + +13 +00:01:06,100 --> 00:01:09,480 +هم عبارة عن antibody mediated بينما النوع الرابع + +14 +00:01:09,480 --> 00:01:11,540 +هو عبارة عن cell mediated immunity + +15 +00:01:14,540 --> 00:01:26,020 +هنحكي على كل من هما بالتفصيل نفس + +16 +00:01:26,020 --> 00:01:34,080 +الصورة نفس + +17 +00:01:39,850 --> 00:01:42,970 +يأتي في الـ Type I Hypersensitivity Reaction أو ما + +18 +00:01:42,970 --> 00:01:49,070 +تسمى بالـ Classical Allergy الـ Antibody المسؤول + +19 +00:01:49,070 --> 00:01:52,690 +عن الموضوع هو عبارة عن IgE Antibody برتبط بالمعصل + +20 +00:01:52,690 --> 00:01:56,090 +والبيزوفيل الريسبترو على سطح المعصل والبيزوفيل + +21 +00:01:56,090 --> 00:02:06,350 +ويوم ما تحدث محصلة ال reaction هو عبارة عن + +22 +00:02:06,350 --> 00:02:07,250 +Anaphylactic Shock + +23 +00:02:13,230 --> 00:02:19,390 +هذه الطريقة تستخدم في الانتبادي الإيجي إيجي إيجي + +24 +00:02:19,390 --> 00:02:20,950 +ايجي ايجي ايجي ايجي ايجي ايجي ايجي ايجي ايجي ايجي + +25 +00:02:20,950 --> 00:02:23,490 +ايجي ايجي ايجي ايجي ايجي ايجي ايجي ايجي ايجي ايجي + +26 +00:02:23,490 --> 00:02:28,690 +ايجي ايجي ايجي ايجي ايجي ايجي ايجي ايجي ايجي ايجي + +27 +00:02:28,690 --> 00:02:29,510 +ايجي ايجي ايجي ايجي ايجي ايجي ايجي ايجي ايجي ايجي + +28 +00:02:29,510 --> 00:02:31,970 +ايجي ايجي ايجي ايجي ايجي ايجي ايجي ايجي ايجي + +29 +00:02:34,910 --> 00:02:40,950 +far away from protection بمعنى انه it may lead to + +30 +00:02:40,950 --> 00:02:44,950 +death طبعا فيه قدر صعب ممكن نشوفها زي ال hay fever + +31 +00:02:44,950 --> 00:02:48,270 +و الأزمة و ال eczema و ال bee stains و ال food + +32 +00:02:48,270 --> 00:02:52,270 +allergy كل هما دولة can be included in such type + +33 +00:02:52,270 --> 00:03:00,010 +of hypersensitivity ال allergen هو عبارة عن non + +34 +00:03:00,010 --> 00:03:04,480 +parasitic antigenالذي يمكن أن يشبه تطبيق الـ + +35 +00:03:04,480 --> 00:03:08,880 +Hypersensitivity response الأليرجين هو اللي بيثبت + +36 +00:03:08,880 --> 00:03:16,020 +بالـ IgE ويشبه تنسيق ميدياتر كيميائي من مصر + +37 +00:03:16,020 --> 00:03:24,690 +وبيزوفيل مثل الأليرجين زي البروتينزمنها سيران + +38 +00:03:24,690 --> 00:03:28,890 +بروتين والفاكسيين، plant pollen، drugs زي + +39 +00:03:28,890 --> 00:03:31,850 +البنسيليان، السالفاناميد، الوكالة، الاناستيزيا، + +40 +00:03:31,850 --> 00:03:37,730 +foods زي الناتس والإيجز والإنسكت، + +41 +00:03:37,730 --> 00:03:42,670 +product زي ال بي فينامو and dust mites، molds، + +42 +00:03:42,670 --> 00:03:46,090 +animal hair and danderكل هذا عبارة عن أمثلة + +43 +00:03:46,090 --> 00:03:52,770 +للاليرجين وما أكثرها طبعا اليوم زادت مع التطور + +44 +00:03:52,770 --> 00:03:57,930 +اللي احنا قاعدين بعيننا نعيشه في الحياة ما هي صفات + +45 +00:03:57,930 --> 00:04:02,330 +الاليرجين دالوا عبارة عن small molecular weight + +46 +00:04:02,330 --> 00:04:07,010 +protein بيصل molecular weight تبعه مابين it range + +47 +00:04:07,010 --> 00:04:12,220 +مابين fifteen to forty thousandsيعتبر specific + +48 +00:04:12,220 --> 00:04:17,800 +protein components في الغالب انزايم it can act in + +49 +00:04:17,800 --> 00:04:23,000 +low dose and it can break the mucous mucosal + +50 +00:04:23,000 --> 00:04:29,340 +membrane وطبعا معظم الاليرجين يpromote البرتو + +51 +00:04:29,340 --> 00:04:34,720 +اميون response وطبعا احسن مثال على الاليرجين زي ما + +52 +00:04:34,720 --> 00:04:39,750 +انتوا شايفين اللي هو DRP1 انزايموالدير بي ون + +53 +00:04:39,750 --> 00:04:43,710 +انزاين بتطلع منها ده هي ال ال فيكال pellets of + +54 +00:04:43,710 --> 00:04:47,890 +dust mites هذي يبرن dust mites هي درماتوفاجويد + +55 +00:04:47,890 --> 00:04:51,510 +تيرانو + +56 +00:04:51,510 --> 00:04:58,310 +سيمنس هذي اسمها ده هي هذي dust mites يعني موجودة + +57 +00:04:58,310 --> 00:05:04,030 +في الغابرة شوفين إيش بتعمل هاي ميوكاس مبرين + +58 +00:05:04,030 --> 00:05:12,190 +contact ميوكاس مبرينصار فيه Stunch of الواحد اللى + +59 +00:05:12,190 --> 00:05:18,790 +هو ال Fecal Mites و بتحتوي على ال DRP-1 شو عمل ال + +60 +00:05:18,790 --> 00:05:26,550 +DRP-1 عمل breaking لل connection + +61 +00:05:26,550 --> 00:05:33,430 +between epithelial cells وبالتالي عمل فتحة دخل + +62 +00:05:34,390 --> 00:05:38,970 +تلقفته antigen-presenting cell قدّبته لـ T + +63 +00:05:38,970 --> 00:05:44,270 +-lymphocytes و الـ T-lymphocyte نشطت بي سيل فطبعا + +64 +00:05:44,270 --> 00:05:48,830 +طلعتلنا antibody الـ antibody قاعد على سطح الماسسل + +65 +00:05:48,830 --> 00:05:53,410 +و البيزوفيل و upon second content a second + +66 +00:05:53,410 --> 00:05:58,990 +exposure بيصير في ارتباط و cross linkingللـ + +67 +00:05:58,990 --> 00:06:02,390 +Antibody مع الـ Antigen على سطح المصدر والبيزوفيل + +68 +00:06:02,390 --> 00:06:06,950 +فبصير فيه Activation للخلية و Degranulation لل + +69 +00:06:06,950 --> 00:06:10,830 +Inflammatory Mediators اللي موجودة فيها هذه هي + +70 +00:06:10,830 --> 00:06:18,250 +السلسل الطبيعي لل .. Atopy مصطلح يطلق على الناس + +71 +00:06:18,250 --> 00:06:23,750 +اللي عندهم Genetic Predisposition for localized + +72 +00:06:23,750 --> 00:06:29,670 +anaphylaxis و ال Atopic Individualفي الغالب عندهم + +73 +00:06:29,670 --> 00:06:37,050 +higher level of IgE and eosinophil مصطلح + +74 +00:06:37,050 --> 00:06:40,150 +هذا بالمناسبة الاتوبي برضه ممكن يطلخ على الناس + +75 +00:06:40,150 --> 00:06:43,210 +اللي عندهم genetic predisposition to induce in + +76 +00:06:43,210 --> 00:06:45,950 +hypersensitivity type one hypersensitivity + +77 +00:06:45,950 --> 00:06:50,630 +reaction ال type one hypersensitivity reaction هو + +78 +00:06:50,630 --> 00:06:55,330 +عبارة بيتحكم في هذا الموضوع في ال IgE production + +79 +00:06:55,330 --> 00:07:00,920 +يعنيعدة جينات Polymorphic جين بما فيها IL-4 + +80 +00:07:00,920 --> 00:07:06,340 +Receptor IL-4 Cytokine Promoted Region FCY + +81 +00:07:06,340 --> 00:07:10,600 +Receptor which has high affinity or low affinity + +82 +00:07:10,600 --> 00:07:17,100 +بيعتمد لل IGE and class II MHC molecule وطبعا هذه + +83 +00:07:17,100 --> 00:07:23,960 +بتعتبر هي المحفظة التي البرتوينفلماتوري رياكشنأو + +84 +00:07:23,960 --> 00:07:29,760 +الـ Inflammation gene كل هذه العوامل مجتمعة تعمل + +85 +00:07:29,760 --> 00:07:33,300 +إذا اجتمعت في شخص بيصير عنده A to B بمعنى بيصير + +86 +00:07:33,300 --> 00:07:37,780 +عنده predisposition to form type 1 + +87 +00:07:37,780 --> 00:07:46,520 +hypersensitivity reaction ما هي مرحلة ال allergic + +88 +00:07:46,520 --> 00:07:49,520 +response في هذا النوع؟ جدول المرحلة هي ال + +89 +00:07:49,520 --> 00:07:53,600 +sensitizationSensitization يعني أنه دخل الـ + +90 +00:07:53,600 --> 00:08:00,500 +Allergy محفظ زي ما قلتلكم تلقفته الـ Antigen + +91 +00:08:00,500 --> 00:08:03,920 +Presenting Cell قدمته لـ T Cell الـ T Helper طبعاً + +92 +00:08:03,920 --> 00:08:08,140 +و T Helper 2 نشطت لـ B Lymphocyte طلعت IGE + +93 +00:08:08,140 --> 00:08:11,640 +Antibody الـ IGE Antibody جاعد على سطح الـ muscle + +94 +00:08:11,640 --> 00:08:14,360 +والبيزوفيل هذا بيسموها Sensitized Cell + +95 +00:08:14,360 --> 00:08:20,960 +وSensitization للشخص اللي صار عنده هذا التفاعلطبعا + +96 +00:08:20,960 --> 00:08:24,500 +تيهي البرتو في هذه الحالة تحتاج ال I L 4 which is + +97 +00:08:24,500 --> 00:08:28,440 +secreted + +98 +00:08:28,440 --> 00:08:30,460 +from تيهي البرتو + +99 +00:08:36,620 --> 00:08:43,020 +هذه هي تغيير البرتو بي سيل الانتراكشن تغيير البرتو + +100 +00:08:43,020 --> 00:08:49,020 +بي سيل الانتراكشن تغيير البرتو بي سيل الانتراكشن + +101 +00:08:49,020 --> 00:08:52,020 +تغيير البرتو بي سيل الانتراكشن تغيير البرتو بي سيل + +102 +00:08:52,020 --> 00:08:55,240 +الانتراكشن تغيير البرتو بي سيل الانتراكشن تغيير + +103 +00:08:55,240 --> 00:08:56,300 +البرتو بي سيل الانتراكشن تغيير البرتو بي سيل + +104 +00:08:56,300 --> 00:08:57,380 +الانتراكشن تغيير البرتو بي سيل الانتراكشن تغيير + +105 +00:08:57,380 --> 00:09:04,600 +البرتو بي سيل الانتراكشن تغيير البرتو بي سيل + +106 +00:09:04,600 --> 00:09:06,650 +الانتراكشن تغيير البرتو بي سيلبصير فيه activation + +107 +00:09:06,650 --> 00:09:10,990 +للخلية وبصير فيه mediator released اللي هي ده هي + +108 +00:09:10,990 --> 00:09:16,030 +الهستامين لكترين ال cytokine وطبعا في التأثير هذه + +109 +00:09:16,030 --> 00:09:19,510 +ال mediator إما early response وإما late response + +110 +00:09:19,510 --> 00:09:21,630 +وعدنا بنحكي في هذا الموضوع + +111 +00:09:25,480 --> 00:09:29,640 +الـ IgE يمكن أن يتواصل إلى مصطلق بيزوفيل من خلال + +112 +00:09:29,640 --> 00:09:33,020 +الـ Fc Portion بيظل الفاب هو اللي فالت ال half + +113 +00:09:33,020 --> 00:09:37,180 +-life of IgE في السيرم هي عبارة عن days بينما لما + +114 +00:09:37,180 --> 00:09:43,860 +بيرتبط بال Fc Receptor تبعه it will increase to + +115 +00:09:43,860 --> 00:09:49,220 +month Fc Epsilon Receptor it has high affinity to + +116 +00:09:49,220 --> 00:09:52,660 +IgE receptor موجود على سطح المص البيزوفيل + +117 +00:09:52,660 --> 00:09:58,230 +unactivated زينوفيلالـ Allergen binding to IgE + +118 +00:09:58,230 --> 00:10:02,410 +attached to FCY receptor triggers the release of + +119 +00:10:02,410 --> 00:10:07,650 +granules from the cell يعني أول ما أثبت الـ + +120 +00:10:07,650 --> 00:10:11,310 +Allergen بالرسيبتورز هو اللي بيعمل degranulation + +121 +00:10:11,310 --> 00:10:16,690 +للمصل والبيزوفيل Upon secondary exposure to the + +122 +00:10:16,690 --> 00:10:20,950 +allergen بيصير فيه ميكانيزم للستاجي التانية وهي ال + +123 +00:10:20,950 --> 00:10:26,160 +activationالـ activation بتاعي لأن ال muscle are + +124 +00:10:26,160 --> 00:10:31,020 +لبرايمد مع الcell لبرايمد + +125 +00:10:31,020 --> 00:10:35,780 +يعني with IgE on their surfaces ماشي لما برتبته + +126 +00:10:35,780 --> 00:10:40,180 +بالاليرجين بيصير cross link it will activate + +127 +00:10:40,180 --> 00:10:43,580 +signal to tyrosine phosphorylation في calcium + +128 +00:10:43,580 --> 00:10:46,480 +influx في degradation and release of mediator + +129 +00:10:50,500 --> 00:10:56,600 +هذا الانتيجين اول اكتشاف تلمفوسايت نشط بلمفوسايت + +130 +00:10:56,600 --> 00:11:01,200 +كوان IGE جالس على سطح المعصّل اول اكتشاف ثانوية + +131 +00:11:01,200 --> 00:11:05,680 +ارتبط بالانتيبادي وصار في cross-linking وصار في + +132 +00:11:05,680 --> 00:11:09,280 +activation وderanulation وطلع ليش الinflammatory + +133 +00:11:09,280 --> 00:11:13,900 +mediators وهذا تأثير الinflammatory mediators هذا + +134 +00:11:13,900 --> 00:11:19,560 +طبعا قد تؤدي إلى الانفلاكتك شوك طبعا هيوفازو + +135 +00:11:19,560 --> 00:11:24,510 +داليشينacute inflammation tissue damage muscle + +136 +00:11:24,510 --> 00:11:28,650 +contraction and bronchoconstriction Inflammatory + +137 +00:11:28,650 --> 00:11:36,050 +mediators في منها mediators زي سموها preformed + +138 +00:11:36,050 --> 00:11:42,090 +preformed mediator وفي اللي هو newly synthesized + +139 +00:11:42,090 --> 00:11:47,450 +mediator طبعا ال preformed جاهزة بتكون مشك يعني + +140 +00:11:47,450 --> 00:11:51,820 +صنعه جاهزة في نفس الالمعصر اللي هو ال بيزوفيل وهي + +141 +00:11:51,820 --> 00:11:56,280 +اللي بتعمل ال first response بينما اللي او ال + +142 +00:11:56,280 --> 00:12:01,440 +immediate reaction يعني بينما ال late phase هو ال + +143 +00:12:01,440 --> 00:12:11,300 +ناتج عن ال mediators اللي اتصمعت upon activation + +144 +00:12:11,300 --> 00:12:15,440 +وطبعا + +145 +00:12:15,440 --> 00:12:18,480 +هي ان اللي هو + +146 +00:12:21,820 --> 00:12:27,640 +الـPrincipal Mediators زي الهستامينهيبرين سيروتنان + +147 +00:12:27,640 --> 00:12:31,200 +وهي تأثيرها increase vascular permeability و + +148 +00:12:31,200 --> 00:12:36,700 +smooth muscle contraction هي ال primary mediators + +149 +00:12:36,700 --> 00:12:42,600 +وفي ناس في كتب بتسميها preformed mediators وفي + +150 +00:12:42,600 --> 00:12:48,020 +اللي هو ال secondary mediators اللي تحت وبرضه هذه + +151 +00:12:48,690 --> 00:12:57,130 +بتعمل الـ late response for this reaction هي الـ + +152 +00:12:57,130 --> 00:13:05,570 +equilibrium prostaglandin and IL-4 و IL-13 هستامين + +153 +00:13:05,570 --> 00:13:10,930 +الهستامين + +154 +00:13:10,930 --> 00:13:17,620 +بيعمل construction of smooth muscle و بيعملبعمل + +155 +00:13:17,620 --> 00:13:21,340 +construction وبالتالي بيصير في weaving التصفيرة مع + +156 +00:13:21,340 --> 00:13:26,280 +النفس بعمل construction of the intestine وبالتالي + +157 +00:13:26,280 --> 00:13:30,640 +بعمل cramp وديارية بعمل vasodilation وزي increase + +158 +00:13:30,640 --> 00:13:38,640 +fluid يعني ادمة وactivate enzyme for tissue tissue + +159 +00:13:38,640 --> 00:13:42,340 +اللي هو breakdown + +160 +00:13:43,840 --> 00:13:48,760 +اليوكترين والبروستاس سايكليين اليوكترين برضه هو + +161 +00:13:48,760 --> 00:13:56,100 +عبارة عن pain inducer بروستاس glanding ملعب ضر + +162 +00:13:56,100 --> 00:14:03,500 +كبير فيه اللي هو ال cloth formation و inhibition + +163 +00:14:03,500 --> 00:14:09,960 +of cloth formation هاي + +164 +00:14:09,960 --> 00:14:15,100 +ال primary yearly mediatorsو هذه الـ Rate Mediator + +165 +00:14:15,100 --> 00:14:19,820 +شوفوا كيف نفخت صار في إيدنا و نفخت هذه ال + +166 +00:14:19,820 --> 00:14:25,700 +immediate effect of long airflow صار في wheezing + +167 +00:14:25,700 --> 00:14:30,640 +وهي ال Late هي + +168 +00:14:30,640 --> 00:14:33,080 +preformed mediator in granules + +169 +00:14:37,610 --> 00:14:41,750 +استامين سايتوكاين تيومان كروس فاكتور ألف عيل وان + +170 +00:14:41,750 --> 00:14:45,950 +عيل ست كيمو أتراكتانتلانيوتروفيل وإزينوفيل إنزايم + +171 +00:14:45,950 --> 00:14:52,590 +زي التريبتيز والكايميز والكتابسينز وthese changes + +172 +00:14:52,590 --> 00:14:55,490 +in connective tissue matrix وبعملوا tissue + +173 +00:14:55,490 --> 00:15:00,670 +breakdown ليكوترين اللي هو secondary mediators + +174 +00:15:00,670 --> 00:15:04,990 +بروستاجلاندين وليكوترين وكل السايتوكاين + +175 +00:15:07,740 --> 00:15:12,440 +بالتالي، تتجمد تجارب التنسيق والمضمون يتحكم على + +176 +00:15:12,440 --> 00:15:14,780 +الاتصال الاجتماعي الاجتماعي الاجتماعي الاجتماعي + +177 +00:15:14,780 --> 00:15:21,860 +الاجتماعي الاجتماعي الاجتماعي الاجتماعي الاجتماعي + +178 +00:15:21,860 --> 00:15:27,360 +الاجتماعي الاجتماعي الاجتماعي الاجتماعي الاجتماعي + +179 +00:15:27,360 --> 00:15:27,640 +الاجتماعي الاجتماعي الاجتماعي الاجتماعي الاجتماعي + +180 +00:15:27,640 --> 00:15:27,680 +الاجتماعي الاجتماعي الاجتماعي الاجتماعي الاجتماعي + +181 +00:15:27,680 --> 00:15:32,400 +الاجتماعي الاجتماعي الاجتما + +182 +00:15:33,690 --> 00:15:38,110 +الأولى كانت تدخل من خلال مصدر ميزوفيل و إيزينوفيل + +183 +00:15:38,110 --> 00:15:48,850 +استعمل إيزينوفيل + +184 +00:15:48,850 --> 00:15:57,150 +لإيزينوفيل + +185 +00:15:57,760 --> 00:16:02,200 +السيطوكاين والميدياتور + +186 +00:16:02,200 --> 00:16:08,140 +الليكوترين بأنواعها بلتليت اكتفات والإيزنوفيل + +187 +00:16:08,140 --> 00:16:13,020 +بإمكانه إعطاء CD4 للجند و 4 بيليمفوس سايت اكتفات + +188 +00:16:13,020 --> 00:16:18,400 +في + +189 +00:16:18,400 --> 00:16:23,900 +معين من ال reaction في localized وفي systemic ال + +190 +00:16:23,900 --> 00:16:27,770 +localizedTarget organ responds to direct contact + +191 +00:16:27,770 --> 00:16:32,750 +with allergen فلو كان في الـGIT بيصير فيه vomiting + +192 +00:16:32,750 --> 00:16:38,590 +و cramping و ديارية و لو كان في ال skin بيصير فيه + +193 +00:16:38,590 --> 00:16:43,750 +rendered inflamed area مع etching و لو كان في + +194 +00:16:43,750 --> 00:16:46,490 +الجهاز التنفسي ال respiratory tract بيصير فيه + +195 +00:16:46,490 --> 00:16:51,350 +airway sensitivity بيتأدي إلى sneezing و rhinitis + +196 +00:16:51,350 --> 00:16:59,240 +أو wheezing و أزمةSystemic بيحصل في Vasodilatation + +197 +00:16:59,240 --> 00:17:02,580 +و Muscle Contraction هذا بيؤدي الى Pronchial + +198 +00:17:02,580 --> 00:17:06,560 +Constriction ادنى and shock هذا هو الانفلاكتك + +199 +00:17:06,560 --> 00:17:10,500 +شوكلر الحقيقي طبعا similar to systemic + +200 +00:17:10,500 --> 00:17:17,020 +inflammation treatment بيأتوا pharmacology بيأتوا + +201 +00:17:17,020 --> 00:17:21,400 +drugs non-steroidal anti-inflammatory اللي هو + +202 +00:17:21,400 --> 00:17:22,520 +كورتيكوستيرويد + +203 +00:17:24,650 --> 00:17:28,070 +اللي هو الـ Non-steroidal بانواعها ثم + +204 +00:17:28,070 --> 00:17:31,810 +Antihistamines to block the histamine receptor + +205 +00:17:31,810 --> 00:17:37,610 +وSteroid الكورتيكوستيرويد وThiophilin أو + +206 +00:17:37,610 --> 00:17:42,270 +Aminophilin أو Epinephrine which prolong increased + +207 +00:17:42,270 --> 00:17:47,630 +cyclic AMP وطبعاً هذا بعمل inhibition ليش لديه + +208 +00:17:47,630 --> 00:17:51,510 +Granulation اليوم بيعملوا Hyposensitization + +209 +00:17:51,510 --> 00:17:53,050 +بيعتبروها immunotherapy + +210 +00:18:10,800 --> 00:18:15,140 +الحاجة الأولانية اما بعمل shifting from t level 2 + +211 +00:18:15,140 --> 00:18:20,060 +to t level 1أو بعمل class watching from IgE ل IgG + +212 +00:18:20,060 --> 00:18:27,660 +وفي كل تل حتين نتخلص من الحساسية طبعا هيه صيفين ال + +213 +00:18:27,660 --> 00:18:35,160 +IgE نزل وطلع ال IgG بداله IgG بعملش حساسية اللي + +214 +00:18:35,160 --> 00:18:39,560 +بعمل حساسية هو ال IgE ليش؟ لأنه ال receptor على + +215 +00:18:39,560 --> 00:18:46,030 +المصل والإذر ال IgG مالهوشهذا هو تجارب الهيبرا + +216 +00:18:46,030 --> 00:18:48,050 +السنسيتيوية الاساسية الاساسية الاساسية الاساسية + +217 +00:18:48,050 --> 00:18:50,610 +الاساسية الاساسية الاساسية الاساسية الاساسية + +218 +00:18:50,610 --> 00:18:52,070 +الاساسية الاساسية الاساسية الاساسية الاساسية + +219 +00:18:52,070 --> 00:18:52,110 +الاساسية الاساسية الاساسية الاساسية الاساسية + +220 +00:18:52,110 --> 00:18:55,790 +الاساسية الاساسية الاساسية الاساسية الاساسية + +221 +00:18:55,790 --> 00:18:55,990 +الاساسية الاساسية الاساسية الاساسية الاساسية + +222 +00:18:55,990 --> 00:18:56,850 +الاساسية الاساسية الاساسية الاساسية الاساسية + +223 +00:18:56,850 --> 00:18:58,010 +الاساسية الاساسية الاساسية الاساسية الاساسية + +224 +00:18:58,010 --> 00:19:01,460 +الاساسية الاساسية الانتيبادي هم IgM أو IgG بكتبته + +225 +00:19:01,460 --> 00:19:04,180 +مع cell surface molecule و بيصير فيه antibody + +226 +00:19:04,180 --> 00:19:07,760 +-antibody complex بنشطه ال complement على سطح + +227 +00:19:07,760 --> 00:19:12,120 +الخلية فبكسر الخلية فسيصبح Hemolysis طبعا + +228 +00:19:12,120 --> 00:19:15,560 +inappropriate response في الوضع الطبيعي it + +229 +00:19:15,560 --> 00:19:19,580 +eliminate foreign cells في الوضع الطبيعي ممكن + +230 +00:19:19,580 --> 00:19:23,880 +يتكون antibody أو auto-antibodyفرصة في انتجن ويعمل + +231 +00:19:23,880 --> 00:19:29,440 +auto immunity disease وبالتالي ال antigen ال + +232 +00:19:29,440 --> 00:19:37,260 +antibody should be tolerated وهي الميكانيزم انتجن + +233 +00:19:37,260 --> 00:19:42,740 +دخل على موجود على سطح الخلية سوري antibody تكون له + +234 +00:19:42,740 --> 00:19:47,600 +قوات ارتبط فيه اما بينشط ال complement وبيعمل + +235 +00:19:47,600 --> 00:19:51,790 +membrane attack complex وبيكسرهاوإما بعمل Antibody + +236 +00:19:51,790 --> 00:19:54,670 +Dependent Cell Mediated Cytotoxicity لأن + +237 +00:19:54,670 --> 00:19:58,410 +الانتيبادي موجود و ال Fc Portion فالد وبالتالي + +238 +00:19:58,410 --> 00:20:01,270 +يقيله ال Fc Portion ويجيجي يقيله ال Receptor على + +239 +00:20:01,270 --> 00:20:10,470 +سطح عدد كتير من الفاجوسيتكسيل والانكيسم فبتعمل + +240 +00:20:10,470 --> 00:20:15,050 +Destruction للخلية وإما بعمل Obsonization ومحصلته + +241 +00:20:15,050 --> 00:20:18,390 +أيضا فاجوسيتوسيز في جميع الحالات بصير Cell + +242 +00:20:18,390 --> 00:20:19,550 +Destruction + +243 +00:20:21,660 --> 00:20:27,480 +عنصر على ذلك ناخد مثال على الـ autoimmunity مثال + +244 +00:20:27,480 --> 00:20:30,940 +المشهور اللي هو goodpastors syndrome هو برعنة + +245 +00:20:30,940 --> 00:20:33,420 +الانتجر بيكون هو برعنة Alpha تلاتة chain of + +246 +00:20:33,420 --> 00:20:36,580 +basement membrane للكولاجين موجود على الكدن + +247 +00:20:36,580 --> 00:20:43,540 +واللنجة متكون Antibody للAlpha تلاتة اللي هو chain + +248 +00:20:43,540 --> 00:20:47,620 +basement membraneو يوم ما يحصل cross-linking مع + +249 +00:20:47,620 --> 00:20:51,600 +الـ receptor و الـ cytotoxic cell أو على سطح الخلق + +250 +00:20:51,600 --> 00:20:55,560 +الـ cytotoxic cell بنشط monocyte و neutrophil و + +251 +00:20:55,560 --> 00:20:59,480 +mesophil طبعا بتفرز كيموكاين which recruit more + +252 +00:20:59,480 --> 00:21:03,900 +neutrophil و طبعا this will lead to self tissue + +253 +00:21:03,900 --> 00:21:13,860 +destruction و هي صورة ال lung كيف صار لها + +254 +00:21:13,860 --> 00:21:20,000 +infarctionمثال آخر اللي هو for an antigen طبعا في + +255 +00:21:20,000 --> 00:21:23,960 +هذا الحالة يوم ما تنقل incompatible blood through + +256 +00:21:23,960 --> 00:21:28,760 +transfusion بيصير transfusion reaction وهي بيصير + +257 +00:21:28,760 --> 00:21:33,780 +اللي هو incompatibility طبعا كلنا بنعرف أنه فصيلة + +258 +00:21:33,780 --> 00:21:37,640 +A عندها انت B وفصيلة B عندها انت A فأي خلل في نقل + +259 +00:21:37,640 --> 00:21:42,800 +أي فصيلة بيدينا اللي هو بيكون فيه strong antibody + +260 +00:21:42,800 --> 00:21:47,090 +جاعت بيستنى ال antigen فهو IgMفيرتبط فيه وبيعمل + +261 +00:21:47,090 --> 00:21:53,910 +اتنينيونيومولاتيكي reaction drugs أيضا ممكن يصير + +262 +00:21:53,910 --> 00:21:58,050 +في نقشة نفس الحكاية ان ال drug يقعد على سطح يرتبط + +263 +00:21:58,050 --> 00:22:04,190 +بانتيجينات على سطح خلايا معينة منها ال RBCsفطبعا + +264 +00:22:04,190 --> 00:22:08,530 +ال drugs بيكون في الوضع الأولاني هو فت فت طبعا + +265 +00:22:08,530 --> 00:22:13,890 +بيصير بيعتبر Epitopes بيعتبر Heptane لما بيقعد على + +266 +00:22:13,890 --> 00:22:18,350 +السطح الخلية بيرتبط ببروتينات في ال membrane بيكبر + +267 +00:22:18,350 --> 00:22:21,150 +و بيصير immunogen بتكوّله antibody اللي بيقدر + +268 +00:22:21,150 --> 00:22:27,970 +يتفاعل مع مين مع ال antigen مع ال Heptane و ال + +269 +00:22:27,970 --> 00:22:35,960 +protein اللي ارتبط فيهالـ .. طبعا ايضا + +270 +00:22:35,960 --> 00:22:41,020 +ممكن الـ Antibody اللى بتكون هو عبارة عن IGG IGG + +271 +00:22:41,020 --> 00:22:45,980 +مايقدرش يعمل تكسير للـ Direct Hemolysis فبالتالي + +272 +00:22:45,980 --> 00:22:51,340 +ممكن خلية تتكسر اما Through ADCC واما Through + +273 +00:22:51,340 --> 00:22:56,960 +Phagocytosis Drug induced thrombocytopenic pair + +274 +00:22:56,960 --> 00:23:04,040 +برا نفس الحكاية تكونAntibody للـ Platelet و + +275 +00:23:04,040 --> 00:23:08,960 +Antibody للـ Platelet وبالتالي صار في Optionized + +276 +00:23:08,960 --> 00:23:14,820 +Platelet طبعا هذه اسمها Destruction by + +277 +00:23:14,820 --> 00:23:19,000 +Phagocytosis + +278 +00:23:19,000 --> 00:23:22,860 +Hepatic + +279 +00:23:22,860 --> 00:23:26,380 +disease of new born طبعا الأرشين compatibility كل + +280 +00:23:26,380 --> 00:23:30,950 +كتير في حدوثة أن ال motherRH negative mother لما + +281 +00:23:30,950 --> 00:23:35,430 +تكون حاملة ب RH positive baby طبعا في ال baby + +282 +00:23:35,430 --> 00:23:39,530 +الأولاني بيعدي لكن during delivery شوية أنتيجينات + +283 +00:23:39,530 --> 00:23:43,390 +ل RH positive بخش على ال mother blood فبتكونله + +284 +00:23:43,390 --> 00:23:47,150 +antibody منه IGG في ال second pregnancy it can + +285 +00:23:47,150 --> 00:23:54,810 +cross the placenta وبيهاجم ال baby second baby هذا + +286 +00:23:54,810 --> 00:23:59,590 +هوهذه أمثلة عن الـ Hypersensitivity Type-2 + +287 +00:23:59,590 --> 00:24:05,470 +Hypersensitivity Reaction Type-3 ماذا يحصل؟ ما + +288 +00:24:05,470 --> 00:24:10,230 +يحصل في الـ Immune Complexes Immune Complexes + +289 +00:24:10,230 --> 00:24:16,070 +Formation ما يحصل؟يتكيّن Antigen Antibody Reaction + +290 +00:24:16,070 --> 00:24:19,270 +بكميات كبيرة بسبب Deposition على الـTissue وهو + +291 +00:24:19,270 --> 00:24:24,370 +طبعاً هذا بنشطنا بيجي يتكلم داخل الـCell + +292 +00:24:24,370 --> 00:24:28,210 +الـPhagocytic Cell بيجي يتخلصنا منه لكن ما بتقدر + +293 +00:24:28,210 --> 00:24:33,970 +فتعمل Degranulation وTissue Damage Payer هي سوليب + +294 +00:24:33,970 --> 00:24:40,160 +الانتجين الانتبادي IGG مع الـComplementانتجار غير + +295 +00:24:40,160 --> 00:24:43,060 +مناسب في الوضع الطبيعي الانتيجين انتجار غير مناسب + +296 +00:24:43,060 --> 00:24:45,640 +في الوضع الطبيعي الانتيجين انتجار بيساعد في + +297 +00:24:45,640 --> 00:24:49,540 +الفلوسيتوسيز وكليرانس الهيار أو الانتيجين لكن + +298 +00:24:49,540 --> 00:24:56,340 +بمجرد أن يكون هناك عدد كبير من الكمبليكسيز يحصل + +299 +00:24:56,340 --> 00:25:00,560 +فيه تشيو دامج طبعا + +300 +00:25:00,560 --> 00:25:05,430 +تابع ثلاثة بيط وسموه others reactionهي الـ + +301 +00:25:05,430 --> 00:25:10,050 +Previously Synthesized Host يمثل فيه Antigen + +302 +00:25:10,050 --> 00:25:13,670 +Exposure to Specific Site إما بإنهيليشن أو إنجيكشن + +303 +00:25:13,670 --> 00:25:19,450 +بيتكون Antibody من نوع IgG مع الانتجين فبيكون IgG + +304 +00:25:19,450 --> 00:25:24,890 +Antigen Complex طبعا هذا إما بنشط الكمليمنت تكون + +305 +00:25:24,890 --> 00:25:31,190 +C3A C5A دي are Anaflatoxin and Chemotactic Agent + +306 +00:25:31,190 --> 00:25:38,660 +ويعملوا Membrane Attack Complexأو انه بتكون ال IGG + +307 +00:25:38,660 --> 00:25:47,280 +و بيعمل ايش بيعمل optionization لليكوسايد و هي + +308 +00:25:47,280 --> 00:25:54,220 +بالتالي it will be phagocytosis or by releasing of + +309 +00:25:54,220 --> 00:26:01,780 +lytic enzyme secretion هذا + +310 +00:26:01,780 --> 00:26:07,040 +هيطبعا هى الانتيجن تكونله antibody في blood + +311 +00:26:07,040 --> 00:26:12,440 +vessels هى فصار فى antibody-antibody complex + +312 +00:26:12,440 --> 00:26:19,780 +انتيجن antibody-antibody complex ممكن ينشطلنا في + +313 +00:26:19,780 --> 00:26:23,940 +agostatic cell تيجي تخلصنا منه و بتقدرش فبتعمل + +314 +00:26:23,940 --> 00:26:26,740 +degranulation فى منطقة الحدث وبالتالي بيصير فى + +315 +00:26:26,740 --> 00:26:28,440 +tissue damaged + +316 +00:26:32,260 --> 00:26:35,040 +Antigen-antibody-immune-complex الـ IgG-mediated + +317 +00:26:35,040 --> 00:26:39,120 +immune-complex disease كميات كبيرة من الانتجين + +318 +00:26:39,120 --> 00:26:44,220 +والانتبادي تشكل كمبليكسات في الدم، إذا لم يتم + +319 +00:26:44,220 --> 00:26:47,980 +إيقافها، يمكن أن تدفعها إلى الورق أو الرقص ويؤثر + +320 +00:26:47,980 --> 00:26:52,720 +على الإنفلام. طبعاً هذا هي المحصلة + +321 +00:26:55,390 --> 00:26:59,690 +Antigen Antibody ده هو Immune Complex اتكون نشطت + +322 +00:26:59,690 --> 00:27:04,370 +انها عدة خلايا الـ Platelet عملت من Micro from با + +323 +00:27:04,370 --> 00:27:09,590 +عي بيزوفيل نشطته عملت Vasoactive Amine وبالتالي + +324 +00:27:09,590 --> 00:27:14,990 +عملت Vasodilator وAedema ال complement في انها C3A + +325 +00:27:14,990 --> 00:27:22,430 +C5A بتتكون و هتقول عبارة عن Chemotactic Factor + +326 +00:27:22,430 --> 00:27:27,770 +و في نفس الوجود انا اعرف لها Toxinطبعا هي ال C5A + +327 +00:27:27,770 --> 00:27:30,850 +نشطة الدنيوتروفيل فهي جت تخلصنا من ال complex + +328 +00:27:30,850 --> 00:27:34,410 +بتقدرش فبتعمل degranulation بيسموها frustrated + +329 +00:27:34,410 --> 00:27:39,430 +phagocytosis ليش؟ مفروض تاكل فماقدرتش تاكل فعملت + +330 +00:27:39,430 --> 00:27:44,170 +digestion outside the cell و بيسموها اللي هو + +331 +00:27:44,170 --> 00:27:49,530 +frustrated phagocytosis طبعا + +332 +00:27:51,390 --> 00:27:55,830 +أو الـ Granule Contents عندما يخرج من الخلية يعمل + +333 +00:27:55,830 --> 00:28:01,010 +تشيو دامج هذا + +334 +00:28:01,010 --> 00:28:06,090 +هو كما تشاهدون هنا يوجد اميون كومبليكس هنا طبعا + +335 +00:28:06,090 --> 00:28:09,250 +الاميون كومبليكس نشطت نشطت نيوتروفيل يأتي تخلصنا + +336 +00:28:09,250 --> 00:28:15,270 +منها و لا تريدها فتعمل تشيو دامج تعمل تشيو دامج + +337 +00:28:15,270 --> 00:28:18,350 +cell membrane damage + +338 +00:28:20,580 --> 00:28:27,240 +نفس الحكاية بتعمل Vasculitis هذا في حالات اللي هو + +339 +00:28:27,240 --> 00:28:30,560 +ال autoimmune أو ال immune complex mediated tissue + +340 +00:28:30,560 --> 00:28:35,460 +injury type 3 immune complex polymorphic nuclear + +341 +00:28:35,460 --> 00:28:39,720 +and macrophage bind to immune complexes via FC + +342 +00:28:39,720 --> 00:28:43,140 +receptor and phagocytase the complex لكن إذا + +343 +00:28:43,140 --> 00:28:50,800 +ماقدرتشبالتالي يمكن أن يسبب انفلامية من خلال + +344 +00:28:50,800 --> 00:28:58,240 +اكتبار كومplement بطلعة C3A C4A C5A ويتعمل فرسترات + +345 +00:28:58,240 --> 00:29:02,860 +فاقوسييتز فرسترات فاقوسييتز هي كيفينيوتر فيها + +346 +00:29:02,860 --> 00:29:06,600 +ماكروفيش ممكن أن يفرسترات فاقوسييتز + +347 +00:29:09,500 --> 00:29:12,080 +هو الـ Degranulate in the area of immune complex + +348 +00:29:12,080 --> 00:29:15,600 +deposition and trigger inflammation يعني انا + +349 +00:29:15,600 --> 00:29:22,460 +unable to eat فتحاول تدخل خارج الجسم مثال + +350 +00:29:22,460 --> 00:29:30,200 +حقيقي برضه على اللي هو ال localized + +351 +00:29:32,130 --> 00:29:36,330 +الخاصة التالية بتسمى + +352 +00:29:36,330 --> 00:29:41,570 +Extrinsic Allergic Alveolitis هو بيصيب الفارمورز + +353 +00:29:41,570 --> 00:29:48,270 +لنجه هدى يدخلوا فيها مفلك أكتينوموائيسيد موجودة في + +354 +00:29:48,270 --> 00:29:53,750 +الـdry and dusty moldy hay بيساولها inhalation by + +355 +00:29:53,750 --> 00:29:57,570 +large amount طبعا ال initial exposure بده يعمل + +356 +00:29:57,570 --> 00:30:02,000 +يكون ان IGG antibody about repeated exposureالـ + +357 +00:30:02,000 --> 00:30:06,820 +Antibody موجود و طبعا يحصل فيه Immune Complexes في + +358 +00:30:06,820 --> 00:30:13,620 +اللغة و Pneumonitis و Alveolitis Generalized + +359 +00:30:13,620 --> 00:30:18,900 +reaction هي Systemic Exposure to Antigen كون Large + +360 +00:30:18,900 --> 00:30:24,700 +amount of IgG Small IgG مع الانتجين Complexes + +361 +00:30:24,700 --> 00:30:28,460 +Difficult to clear circulate and become deposited + +362 +00:30:28,460 --> 00:30:38,030 +all over the bodyطبعا تصبح تشيو دمج بسبب اكتفيش + +363 +00:30:38,030 --> 00:30:41,950 +فجوسيتكسل + +364 +00:30:41,950 --> 00:30:46,970 +هاي مثال اخر serum sickness طبعا انا انترالينس او + +365 +00:30:46,970 --> 00:30:50,450 +انترالينس او انترالينس او انترالينس او انترالينس + +366 +00:30:56,350 --> 00:31:00,570 +سم حققناه في حصان أخدنا بعد هيكا ال serum تبع + +367 +00:31:00,570 --> 00:31:04,530 +الحصان و طلعنا ال antibody تبعه هذا ممكن يكون ك + +368 +00:31:04,530 --> 00:31:14,410 +vaccine طبعا يوم ما أبقى يوم + +369 +00:31:14,410 --> 00:31:18,890 +ما ناخده و نحقنه في إنسان طبعا هذا ممكن الإنسان + +370 +00:31:18,890 --> 00:31:23,710 +طبعا اللي ماخد ال venom هيصير في immune complexes + +371 +00:31:23,710 --> 00:31:28,280 +و هتترسب على ال joint و skin و kidneyو تعمل مشاكل + +372 +00:31:28,280 --> 00:31:33,720 +هاي ال serum sickness هاي ال free antigen في الأول + +373 +00:31:33,720 --> 00:31:40,280 +بعد ذلك طبعا صار في immune complexes و هاي ال + +374 +00:31:40,280 --> 00:31:44,800 +symptoms و بدت تتكون large amount of antigen such + +375 +00:31:44,800 --> 00:31:46,960 +as injection و free serum + +376 +00:31:51,290 --> 00:31:56,630 +لوكاليز ديزييت ترسّب الimmune complexes على الجون + +377 +00:31:56,630 --> 00:32:00,470 +بيعمل inflammation و arthritis وعالكدنى بيعمل + +378 +00:32:00,470 --> 00:32:05,980 +glomerulonephritisAuto immunity مثال آخر SLE + +379 +00:32:05,980 --> 00:32:10,480 +Systemic Leukocytic Rheumatosis في اللي بيصير طارد + +380 +00:32:10,480 --> 00:32:15,380 +الإنسان للشمس Ultraviolet light أو cell death و هي + +381 +00:32:15,380 --> 00:32:21,660 +بيصير في impaired apoptic cell clearance لأن هذا + +382 +00:32:21,660 --> 00:32:24,680 +بيؤدي إلى نيكلار كروتين مع DNA exposed to the + +383 +00:32:24,680 --> 00:32:31,420 +circulation طبعا Auto antibody بتكون لهمالـ B-cell + +384 +00:32:31,420 --> 00:32:36,920 +priming زي الـ class switching to IgG هيعمل .. + +385 +00:32:36,920 --> 00:32:40,580 +هيرتبط معاياش مع الـ Antigen ويعمل Immune + +386 +00:32:40,580 --> 00:32:47,160 +Complexes هي نفس الحكاية Circulating B lymphocyte + +387 +00:32:47,160 --> 00:32:54,220 +بترتبط بطبيعياش بـ Antigenماشي تاخدت قدمته ل T + +388 +00:32:54,220 --> 00:32:58,680 +lymphocyte نشطتها كونت Antibody ال Antibody ارتبط + +389 +00:32:58,680 --> 00:33:02,400 +في اللي هيش ال Antigen كون Immune Complexes إجت + +390 +00:33:02,400 --> 00:33:11,980 +الفاجوسة تكسل و طبعا ماقدرتش تخلصنا منه فبصير فيه + +391 +00:33:11,980 --> 00:33:19,580 +Deposition و Injury at site of infectionوحصلة + +392 +00:33:19,580 --> 00:33:25,480 +tissue damage type 4 hypersensitivity reaction هو + +393 +00:33:25,480 --> 00:33:30,120 +الـ delete type hypersensitivity reaction وهذا + +394 +00:33:30,120 --> 00:33:35,060 +يتمثل بتنشيط تيل بار واحد مع cytotoxic CD8-T + +395 +00:33:35,060 --> 00:33:39,840 +lymphocyte الـ cytokine اللي بطلع من تيل بار واحد + +396 +00:33:39,840 --> 00:33:44,160 +بنشطلنا الماكرافيج والماكرافيج بتعمل delete type + +397 +00:33:44,160 --> 00:33:49,390 +hypersensitivity reactionT برواحة cell release + +398 +00:33:49,390 --> 00:33:53,690 +cytokine to activate macrophage بيعمل inflammation + +399 +00:33:53,690 --> 00:33:57,830 +and tissue damage Continued macrophage activation + +400 +00:33:57,830 --> 00:34:02,010 +بيؤدي ل chronic inflammation و هذا بيؤدي ل tissue + +401 +00:34:02,010 --> 00:34:08,110 +lesion و scarring و granuloma ال reaction ممكن + +402 +00:34:08,110 --> 00:34:12,350 +يكون delete because delete type hypersensitivity + +403 +00:34:12,350 --> 00:34:19,670 +response بيوصل طبعا ال reactionحدوثه بعد 24 إلى 72 + +404 +00:34:19,670 --> 00:34:26,430 +ساعة after exposure rather than minutes يعني + +405 +00:34:26,430 --> 00:34:30,950 +التفارق بيحصل بعد 24 إلى 72 ساعة player T helper + +406 +00:34:30,950 --> 00:34:35,130 +one macrophage normally necessary immune + +407 +00:34:35,130 --> 00:34:39,710 +protection against intracellular pathogen لكن if + +408 +00:34:39,710 --> 00:34:42,090 +prolonged response lead to extensive tissue + +409 +00:34:42,090 --> 00:34:47,860 +destructionمرضه بيتمثل بأكتر من Stage أول Stage + +410 +00:34:47,860 --> 00:34:51,700 +اللي هو Sensitization أيش اللي بيصير؟ والله يتيهي + +411 +00:34:51,700 --> 00:34:54,040 +البرامو .. مين مولي تيهي البراسيل؟ يعني إيش؟ يعني + +412 +00:34:54,040 --> 00:34:58,580 +شافت ال antigen قبل هيك طب إيش بتعمل؟ قالوا + +413 +00:34:58,580 --> 00:35:03,120 +against delayed type hypersensitivity antigen اه + +414 +00:35:03,120 --> 00:35:08,480 +Renated شو اللي خلاها الست اتنشط ب Identity Cell + +415 +00:35:08,480 --> 00:35:12,140 +during Sensitization Stageالعزيزة الـ T-Helper + +416 +00:35:12,140 --> 00:35:14,260 +cell can activate macrophage and trigger + +417 +00:35:14,260 --> 00:35:19,280 +inflammatory response ايوة first exposure انتجين + +418 +00:35:19,280 --> 00:35:27,200 +presenting cell أخدت الانتجين قدمته مرتبط بالامر C + +419 +00:35:27,200 --> 00:35:32,620 +-molecule ل T cell اللي هو CD4 T-Helper cell طبعا + +420 +00:35:32,620 --> 00:35:37,860 +في هذه الحالة صار مشتقت و إدتني T-Helper واحد + +421 +00:35:39,560 --> 00:35:45,640 +تقريبا 1 تقريبا 1 تقريبا + +422 +00:35:45,640 --> 00:35:51,320 +1 + +423 +00:35:51,320 --> 00:35:53,120 +تقريبا 1 تقريبا 1 تقريبا 1 تقريبا 1 تقريبا 1 + +424 +00:35:53,120 --> 00:35:53,240 +تقريبا 1 تقريبا 1 تقريبا 1 تقريبا 1 تقريبا 1 + +425 +00:35:53,240 --> 00:35:53,760 +تقريبا 1 تقريبا 1 تقريبا 1 تقريبا 1 تقريبا 1 + +426 +00:35:53,760 --> 00:35:54,440 +تقريبا 1 تقريبا 1 تقريبا 1 تقريبا 1 تقريبا 1 + +427 +00:35:54,440 --> 00:36:03,600 +تقريبا 1 تقريبا 1 تقريبا 1 تقريبا 1 تق + +428 +00:36:05,250 --> 00:36:13,450 +سيكون عارف و تيهيلبر وان ميموري مستعملت تفرش + +429 +00:36:13,450 --> 00:36:16,650 +سايتوكاين ذاتي الجامعة انتفارون تيومون اكسوس + +430 +00:36:16,650 --> 00:36:23,690 +فاكتور ألف وبيتا وتعمل تشويه دمج وإنفلاميشين ال + +431 +00:36:23,690 --> 00:36:27,570 +IL2 أيضا يستعمل تشويه سايتوكسك تيهيلبر وان + +432 +00:36:27,570 --> 00:36:34,490 +بالإضافة تيهيلبر وان كيموكاين 4 مايكروفيج مستعملت + +433 +00:36:35,910 --> 00:36:38,550 +العيال التلاتة GMC-SF يمكن أن تزداد ميكروفيج مونو + +434 +00:36:38,550 --> 00:36:40,470 +سايت ميكروفيج ميكروفيج ميكروفيج ميكروفيج ميكروفيج + +435 +00:36:40,470 --> 00:36:41,530 +ميكروفيج ميكروفيج ميكروفيج ميكروفيج ميكروفيج + +436 +00:36:41,530 --> 00:36:44,650 +ميكروفيج ميكروفيج ميكروفيج ميكروفيج ميكروفيج + +437 +00:36:44,650 --> 00:36:45,670 +ميكروفيج ميكروفيج ميكروفيج ميكروفيج ميكروفيج + +438 +00:36:45,670 --> 00:36:45,690 +ميكروفيج ميكروفيج ميكروفيج ميكروفيج ميكروفيج + +439 +00:36:45,690 --> 00:36:52,590 +ميكروفيج ميكروفيج ميكروفيج ميكروفيج ميكروفيج + +440 +00:36:52,590 --> 00:36:56,450 +ميكروفيج + +441 +00:36:56,450 --> 00:37:03,330 +ميكرو + +442 +00:37:05,470 --> 00:37:10,350 +أي ساكند اكسبوجر من موري تير برسيل حتى ولا افكتور + +443 +00:37:10,350 --> 00:37:13,590 +تير برسيل with secret cytokine, inflammatory + +444 +00:37:13,590 --> 00:37:19,330 +cytokine, chemokine for phagocytes recruitment شره + +445 +00:37:19,330 --> 00:37:23,290 +الجامعة انترفيرون more activated macrophage to + +446 +00:37:23,290 --> 00:37:27,210 +exposure sitesAt exposure sites mostly non + +447 +00:37:27,210 --> 00:37:31,710 +-specific inflammatory cell زي الـ macrophage و + +448 +00:37:31,710 --> 00:37:36,050 +few antigen specific cell زي الـ T lymphocytes are + +449 +00:37:36,050 --> 00:37:40,030 +present هي + +450 +00:37:40,030 --> 00:37:46,930 +الـ T البربونة شتت لنا macrophage طبعا هذا يوم + +451 +00:37:46,930 --> 00:37:51,190 +يحصل في chronic activation للميكروفاج تعمل ما يسمى + +452 +00:37:51,190 --> 00:37:56,900 +بالـ granuloma اللي هوFormation أيها مليانة بـ + +453 +00:37:56,900 --> 00:38:03,660 +macrophage محاطة بـ T-cell بكتيريا لا يمكن ان تكون + +454 +00:38:03,660 --> 00:38:10,020 +اختلطت تكون فلورا جرانيولوما Formation وهي طبعا في + +455 +00:38:10,020 --> 00:38:14,960 +continuous macrophage ذاتي البروان اكتفيشن بس هذا + +456 +00:38:14,960 --> 00:38:19,560 +بيقدي الهيلتك انزعيم و tissue damage اي جرانيولوما + +457 +00:38:19,560 --> 00:38:20,920 +Formation + +458 +00:38:24,330 --> 00:38:28,590 +كمتك درماتيتس طبعا مثال آخر من أمثلة delayed type + +459 +00:38:28,590 --> 00:38:34,130 +hypersensitivity طبعا هذا في عدة أمثلة منها المثال + +460 +00:38:34,130 --> 00:38:41,890 +الأول هو poison أويج هو عبارة عن classic type شو + +461 +00:38:41,890 --> 00:38:45,650 +اللي بيصير طبعا هذا ال poison موجود على أوراق بعض + +462 +00:38:45,650 --> 00:38:53,140 +النباتات على شكل oil يوم ما حد يمسكهطبعاً بيصيله + +463 +00:38:53,140 --> 00:38:57,140 +absorption by skin تتلقى فى antigen-presenting + +464 +00:38:57,140 --> 00:39:00,740 +cell و بتقدمه لتيل بر واحد و بتعمل sensitization + +465 +00:39:00,740 --> 00:39:06,580 +upon secondary explosion تيل بر واحد memory cell + +466 +00:39:06,580 --> 00:39:11,780 +بتنشط و بتعمل delayed type hypersensitivity هى ده + +467 +00:39:11,780 --> 00:39:19,700 +هى هى النباتات هى ال poison هى فيه toxicodendron + +468 +00:39:19,700 --> 00:39:27,470 +materialبنتا ديكا كاتيكول substance تحتوي على هذه + +469 +00:39:27,470 --> 00:39:31,410 +المادة بتخش can be absorbed تتلقفها تجيب + +470 +00:39:31,410 --> 00:39:35,050 +presenting cell تقدمها ل T lymphocyte اللي بتبدأ + +471 +00:39:35,050 --> 00:39:41,730 +تفرز هذا هي cytokine بتنشط اللي هو ال macro phase + +472 +00:39:41,730 --> 00:39:48,770 +وطبعا بيصير فيه tissue damageمثلًا آخر اللي هو الـ + +473 +00:39:48,770 --> 00:39:51,430 +small molecules اللي موجودة في اللواعي الداخلية زي + +474 +00:39:51,430 --> 00:39:56,050 +النكل والكروم أيضًا can act as a haptin الجسم + +475 +00:39:56,050 --> 00:39:59,850 +بيمطسها ترتبط ببروتينات الجسم من داخلها وبتصير + +476 +00:39:59,850 --> 00:40:02,350 +immunogen بتتلقى في antigen presenting cell + +477 +00:40:02,350 --> 00:40:06,230 +وبتقدمها ل T cell طبعًا ال T cell هتتنشط ي البروان + +478 +00:40:06,230 --> 00:40:11,530 +تتنشط وتنشط لنا ال macro phase اللي هتعمل اللي هو + +479 +00:40:11,530 --> 00:40:16,530 +tissue damage ال lips ال gloves + +480 +00:40:17,560 --> 00:40:21,600 +لفظ اللي مليانة باودر نفس الحكاية الباودر can be + +481 +00:40:21,600 --> 00:40:25,840 +absorbed by skin و بيخش على شكل هابتين برتبط + +482 +00:40:25,840 --> 00:40:31,000 +بالبروتينات تحور إليها immunogen بنشط طبعا تاخدوا + +483 +00:40:31,000 --> 00:40:34,040 +antigen presenting cell و بنشطتيه البروان اللي + +484 +00:40:34,040 --> 00:40:36,340 +بتنشط microphage و بتعمل tissue damage + +485 +00:40:39,270 --> 00:40:43,190 +أيضا مثال آخر الـ Mantox test أو الـ Mycobacterial + +486 +00:40:43,190 --> 00:40:46,650 +tuberculosis طبعا هذا purified protein derivative + +487 +00:40:46,650 --> 00:40:49,810 +بيحقن تحت الجلد و بنستنى عليه اربع و عشرين ات + +488 +00:40:49,810 --> 00:40:52,530 +تمانى و اربعين ساعة اتمانى اربعين اتنين و سبعين + +489 +00:40:52,530 --> 00:40:57,450 +sorry ساعة و بنشوف اذا كان صار wheel and flare + +490 +00:40:57,450 --> 00:41:00,670 +reaction او بيسموه swelling سهل تشوف اذا في + +491 +00:41:00,670 --> 00:41:03,350 +swelling معناته في previous exposure مافيش + +492 +00:41:03,350 --> 00:41:08,840 +swelling معناته فيش previous exposureطبعا هذه + +493 +00:41:08,840 --> 00:41:14,300 +الأمثلة عن الـDelete Type Hypersensitivity كلها + +494 +00:41:14,300 --> 00:41:18,960 +وشو بتعمل Clinical Sign وHistological Feature هذه + +495 +00:41:18,960 --> 00:41:24,620 +طبعا نشرة عن الـDelete Type Hypersensitivity + +496 +00:41:24,620 --> 00:41:31,380 +وملاقتها بتجه البروان هذه الأربع أنواع ملخصين وكل + +497 +00:41:31,380 --> 00:41:35,180 +نوع مين بتنشط فيه وإيش ال clinical manifestation + +498 +00:41:35,180 --> 00:41:41,880 +اللي بتصير أثناءهوبهيك بنكون خلصنا أول section من + +499 +00:41:41,880 --> 00:41:45,000 +هذه المحاضرة وهو Hypersensitivity + diff --git a/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/PUixi-Psy3Y_raw.srt b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/PUixi-Psy3Y_raw.srt new file mode 100644 index 0000000000000000000000000000000000000000..7a6ba08198c0792d0d7edf630a966d6c6f32b36f --- /dev/null +++ b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/PUixi-Psy3Y_raw.srt @@ -0,0 +1,2024 @@ +1 +00:00:02,530 --> 00:00:07,590 +بسم الله الرحمن الرحيم وصلنا + +2 +00:00:07,590 --> 00:00:12,330 +الان الى ال immunoclinical immunology او clinical + +3 +00:00:12,330 --> 00:00:19,850 +immunology part و هنبدأ بال immunopathology و ال + +4 +00:00:19,850 --> 00:00:27,150 +disorders of immune response و يقسموها الى تلت + +5 +00:00:27,150 --> 00:00:32,200 +أنواع أساسيةجالو اما exaggerated يعني over + +6 +00:00:32,200 --> 00:00:35,580 +reactive in your response وبتتمثل + +7 +00:00:35,580 --> 00:00:42,660 +بالhypersensitivity reaction واما deficient وطبعا + +8 +00:00:43,920 --> 00:00:49,740 +المثال عليها immunodeficiency or misdirected وطبعا + +9 +00:00:49,740 --> 00:00:54,640 +هذا هنحكي في ال autoimmune disease هنبدأ في أول + +10 +00:00:54,640 --> 00:00:58,060 +معنى هو ال hypersensitivity reaction وطبعا هذا + +11 +00:00:58,060 --> 00:01:02,240 +الجدول بيبين أن الأربع أنواع مختلفة من ال + +12 +00:01:02,240 --> 00:01:06,100 +hypersensitivity reaction وإذا بتلاحظوا أول تلاتة + +13 +00:01:06,100 --> 00:01:09,480 +هم عبارة عن antibody mediated بينما النوع الرابع + +14 +00:01:09,480 --> 00:01:11,540 +هو عبارة عن cell mediated immunity + +15 +00:01:14,540 --> 00:01:26,020 +هنحكي على كل من هما بالتفصيل نفس + +16 +00:01:26,020 --> 00:01:34,080 +الصورة نفس + +17 +00:01:34,080 --> 00:01:34,080 +الحكاية + +18 +00:01:39,850 --> 00:01:42,970 +يأتي في الـ Type I Hypersensitivity Reaction أو ما + +19 +00:01:42,970 --> 00:01:49,070 +تسمى بالـ Classical Allergy الـ Antibody المسؤول + +20 +00:01:49,070 --> 00:01:52,690 +عن الموضوع هو عبارة عن IgE Antibody برتبط بالمعصل + +21 +00:01:52,690 --> 00:01:56,090 +والبيزوفيل الريسبترو على سطح المعصل والبيزوفيل + +22 +00:01:56,090 --> 00:02:06,350 +ويوم ما تحدث محصلة ال reaction هو عبارة عن + +23 +00:02:06,350 --> 00:02:07,250 +Anaphylactic Shock + +24 +00:02:13,230 --> 00:02:19,390 +هذه الطريقة تستخدم في الانتبادي الإيجي إيجي إيجي + +25 +00:02:19,390 --> 00:02:20,950 +ايجي ايجي ايجي ايجي ايجي ايجي ايجي ايجي ايجي ايجي + +26 +00:02:20,950 --> 00:02:23,490 +ايجي ايجي ايجي ايجي ايجي ايجي ايجي ايجي ايجي ايجي + +27 +00:02:23,490 --> 00:02:28,690 +ايجي ايجي ايجي ايجي ايجي ايجي ايجي ايجي ايجي ايجي + +28 +00:02:28,690 --> 00:02:29,510 +ايجي ايجي ايجي ايجي ايجي ايجي ايجي ايجي ايجي ايجي + +29 +00:02:29,510 --> 00:02:31,970 +ايجي ايجي ايجي ايجي ايجي ايجي ايجي ايجي ايجي + +30 +00:02:34,910 --> 00:02:40,950 +far away from protection بمعنى انه it may lead to + +31 +00:02:40,950 --> 00:02:44,950 +death طبعا فيه قدر صعب ممكن نشوفها زي ال hay fever + +32 +00:02:44,950 --> 00:02:48,270 +و الأزمة و ال eczema و ال bee stains و ال food + +33 +00:02:48,270 --> 00:02:52,270 +allergy كل هما دولة can be included in such type + +34 +00:02:52,270 --> 00:03:00,010 +of hypersensitivity ال allergen هو عبارة عن non + +35 +00:03:00,010 --> 00:03:04,480 +parasitic antigenالذي يمكن أن يشبه تطبيق الـ + +36 +00:03:04,480 --> 00:03:08,880 +Hypersensitivity response الأليرجين هو اللي بيثبت + +37 +00:03:08,880 --> 00:03:16,020 +بالـ IgE ويشبه تنسيق ميدياتر كيميائي من مصر + +38 +00:03:16,020 --> 00:03:24,690 +وبيزوفيل مثل الأليرجين زي البروتينزمنها سيران + +39 +00:03:24,690 --> 00:03:28,890 +بروتين والفاكسيين، plant pollen، drugs زي + +40 +00:03:28,890 --> 00:03:31,850 +البنسيليان، السالفاناميد، الوكالة، الاناستيزيا، + +41 +00:03:31,850 --> 00:03:37,730 +foods زي الناتس والإيجز والإنسكت، + +42 +00:03:37,730 --> 00:03:42,670 +product زي ال بي فينامو and dust mites، molds، + +43 +00:03:42,670 --> 00:03:46,090 +animal hair and danderكل هذا عبارة عن أمثلة + +44 +00:03:46,090 --> 00:03:52,770 +للاليرجين وما أكثرها طبعا اليوم زادت مع التطور + +45 +00:03:52,770 --> 00:03:57,930 +اللي احنا قاعدين بعيننا نعيشه في الحياة ما هي صفات + +46 +00:03:57,930 --> 00:04:02,330 +الاليرجين دالوا عبارة عن small molecular weight + +47 +00:04:02,330 --> 00:04:07,010 +protein بيصل molecular weight تبعه مابين it range + +48 +00:04:07,010 --> 00:04:12,220 +مابين fifteen to forty thousandsيعتبر specific + +49 +00:04:12,220 --> 00:04:17,800 +protein components في الغالب انزايم it can act in + +50 +00:04:17,800 --> 00:04:23,000 +low dose and it can break the mucous mucosal + +51 +00:04:23,000 --> 00:04:29,340 +membrane وطبعا معظم الاليرجين يpromote البرتو + +52 +00:04:29,340 --> 00:04:34,720 +اميون response وطبعا احسن مثال على الاليرجين زي ما + +53 +00:04:34,720 --> 00:04:39,750 +انتوا شايفين اللي هو DRP1 انزايموالدير بي ون + +54 +00:04:39,750 --> 00:04:43,710 +انزاين بتطلع منها ده هي ال ال فيكال pellets of + +55 +00:04:43,710 --> 00:04:47,890 +dust mites هذي يبرن dust mites هي درماتوفاجويد + +56 +00:04:47,890 --> 00:04:51,510 +تيرانو + +57 +00:04:51,510 --> 00:04:58,310 +سيمنس هذي اسمها ده هي هذي dust mites يعني موجودة + +58 +00:04:58,310 --> 00:05:04,030 +في الغابرة شوفين إيش بتعمل هاي ميوكاس مبرين + +59 +00:05:04,030 --> 00:05:12,190 +contact ميوكاس مبرينصار فيه Stunch of الواحد اللى + +60 +00:05:12,190 --> 00:05:18,790 +هو ال Fecal Mites و بتحتوي على ال DRP-1 شو عمل ال + +61 +00:05:18,790 --> 00:05:26,550 +DRP-1 عمل breaking لل connection + +62 +00:05:26,550 --> 00:05:33,430 +between epithelial cells وبالتالي عمل فتحة دخل + +63 +00:05:34,390 --> 00:05:38,970 +تلقفته antigen-presenting cell قدّبته لـ T + +64 +00:05:38,970 --> 00:05:44,270 +-lymphocytes و الـ T-lymphocyte نشطت بي سيل فطبعا + +65 +00:05:44,270 --> 00:05:48,830 +طلعتلنا antibody الـ antibody قاعد على سطح الماسسل + +66 +00:05:48,830 --> 00:05:53,410 +و البيزوفيل و upon second content a second + +67 +00:05:53,410 --> 00:05:58,990 +exposure بيصير في ارتباط و cross linkingللـ + +68 +00:05:58,990 --> 00:06:02,390 +Antibody مع الـ Antigen على سطح المصدر والبيزوفيل + +69 +00:06:02,390 --> 00:06:06,950 +فبصير فيه Activation للخلية و Degranulation لل + +70 +00:06:06,950 --> 00:06:10,830 +Inflammatory Mediators اللي موجودة فيها هذه هي + +71 +00:06:10,830 --> 00:06:18,250 +السلسل الطبيعي لل .. Atopy مصطلح يطلق على الناس + +72 +00:06:18,250 --> 00:06:23,750 +اللي عندهم Genetic Predisposition for localized + +73 +00:06:23,750 --> 00:06:29,670 +anaphylaxis و ال Atopic Individualفي الغالب عندهم + +74 +00:06:29,670 --> 00:06:37,050 +higher level of IgE and eosinophil مصطلح + +75 +00:06:37,050 --> 00:06:40,150 +هذا بالمناسبة الاتوبي برضه ممكن يطلخ على الناس + +76 +00:06:40,150 --> 00:06:43,210 +اللي عندهم genetic predisposition to induce in + +77 +00:06:43,210 --> 00:06:45,950 +hypersensitivity type one hypersensitivity + +78 +00:06:45,950 --> 00:06:50,630 +reaction ال type one hypersensitivity reaction هو + +79 +00:06:50,630 --> 00:06:55,330 +عبارة بيتحكم في هذا الموضوع في ال IgE production + +80 +00:06:55,330 --> 00:07:00,920 +يعنيعدة جينات Polymorphic جين بما فيها IL-4 + +81 +00:07:00,920 --> 00:07:06,340 +Receptor IL-4 Cytokine Promoted Region FCY + +82 +00:07:06,340 --> 00:07:10,600 +Receptor which has high affinity or low affinity + +83 +00:07:10,600 --> 00:07:17,100 +بيعتمد لل IGE and class II MHC molecule وطبعا هذه + +84 +00:07:17,100 --> 00:07:23,960 +بتعتبر هي المحفظة التي البرتوينفلماتوري رياكشنأو + +85 +00:07:23,960 --> 00:07:29,760 +الـ Inflammation gene كل هذه العوامل مجتمعة تعمل + +86 +00:07:29,760 --> 00:07:33,300 +إذا اجتمعت في شخص بيصير عنده A to B بمعنى بيصير + +87 +00:07:33,300 --> 00:07:37,780 +عنده predisposition to form type 1 + +88 +00:07:37,780 --> 00:07:46,520 +hypersensitivity reaction ما هي مرحلة ال allergic + +89 +00:07:46,520 --> 00:07:49,520 +response في هذا النوع؟ جدول المرحلة هي ال + +90 +00:07:49,520 --> 00:07:53,600 +sensitizationSensitization يعني أنه دخل الـ + +91 +00:07:53,600 --> 00:08:00,500 +Allergy محفظ زي ما قلتلكم تلقفته الـ Antigen + +92 +00:08:00,500 --> 00:08:03,920 +Presenting Cell قدمته لـ T Cell الـ T Helper طبعاً + +93 +00:08:03,920 --> 00:08:08,140 +و T Helper 2 نشطت لـ B Lymphocyte طلعت IGE + +94 +00:08:08,140 --> 00:08:11,640 +Antibody الـ IGE Antibody جاعد على سطح الـ muscle + +95 +00:08:11,640 --> 00:08:14,360 +والبيزوفيل هذا بيسموها Sensitized Cell + +96 +00:08:14,360 --> 00:08:20,960 +وSensitization للشخص اللي صار عنده هذا التفاعلطبعا + +97 +00:08:20,960 --> 00:08:24,500 +تيهي البرتو في هذه الحالة تحتاج ال I L 4 which is + +98 +00:08:24,500 --> 00:08:28,440 +secreted + +99 +00:08:28,440 --> 00:08:30,460 +from تيهي البرتو + +100 +00:08:36,620 --> 00:08:43,020 +هذه هي تغيير البرتو بي سيل الانتراكشن تغيير البرتو + +101 +00:08:43,020 --> 00:08:49,020 +بي سيل الانتراكشن تغيير البرتو بي سيل الانتراكشن + +102 +00:08:49,020 --> 00:08:52,020 +تغيير البرتو بي سيل الانتراكشن تغيير البرتو بي سيل + +103 +00:08:52,020 --> 00:08:55,240 +الانتراكشن تغيير البرتو بي سيل الانتراكشن تغيير + +104 +00:08:55,240 --> 00:08:56,300 +البرتو بي سيل الانتراكشن تغيير البرتو بي سيل + +105 +00:08:56,300 --> 00:08:57,380 +الانتراكشن تغيير البرتو بي سيل الانتراكشن تغيير + +106 +00:08:57,380 --> 00:09:04,600 +البرتو بي سيل الانتراكشن تغيير البرتو بي سيل + +107 +00:09:04,600 --> 00:09:06,650 +الانتراكشن تغيير البرتو بي سيلبصير فيه activation + +108 +00:09:06,650 --> 00:09:10,990 +للخلية وبصير فيه mediator released اللي هي ده هي + +109 +00:09:10,990 --> 00:09:16,030 +الهستامين لكترين ال cytokine وطبعا في التأثير هذه + +110 +00:09:16,030 --> 00:09:19,510 +ال mediator إما early response وإما late response + +111 +00:09:19,510 --> 00:09:21,630 +وعدنا بنحكي في هذا الموضوع + +112 +00:09:25,480 --> 00:09:29,640 +الـ IgE يمكن أن يتواصل إلى مصطلق بيزوفيل من خلال + +113 +00:09:29,640 --> 00:09:33,020 +الـ Fc Portion بيظل الفاب هو اللي فالت ال half + +114 +00:09:33,020 --> 00:09:37,180 +-life of IgE في السيرم هي عبارة عن days بينما لما + +115 +00:09:37,180 --> 00:09:43,860 +بيرتبط بال Fc Receptor تبعه it will increase to + +116 +00:09:43,860 --> 00:09:49,220 +month Fc Epsilon Receptor it has high affinity to + +117 +00:09:49,220 --> 00:09:52,660 +IgE receptor موجود على سطح المص البيزوفيل + +118 +00:09:52,660 --> 00:09:58,230 +unactivated زينوفيلالـ Allergen binding to IgE + +119 +00:09:58,230 --> 00:10:02,410 +attached to FCY receptor triggers the release of + +120 +00:10:02,410 --> 00:10:07,650 +granules from the cell يعني أول ما أثبت الـ + +121 +00:10:07,650 --> 00:10:11,310 +Allergen بالرسيبتورز هو اللي بيعمل degranulation + +122 +00:10:11,310 --> 00:10:16,690 +للمصل والبيزوفيل Upon secondary exposure to the + +123 +00:10:16,690 --> 00:10:20,950 +allergen بيصير فيه ميكانيزم للستاجي التانية وهي ال + +124 +00:10:20,950 --> 00:10:26,160 +activationالـ activation بتاعي لأن ال muscle are + +125 +00:10:26,160 --> 00:10:31,020 +لبرايمد مع الcell لبرايمد + +126 +00:10:31,020 --> 00:10:35,780 +يعني with IgE on their surfaces ماشي لما برتبته + +127 +00:10:35,780 --> 00:10:40,180 +بالاليرجين بيصير cross link it will activate + +128 +00:10:40,180 --> 00:10:43,580 +signal to tyrosine phosphorylation في calcium + +129 +00:10:43,580 --> 00:10:46,480 +influx في degradation and release of mediator + +130 +00:10:50,500 --> 00:10:56,600 +هذا الانتيجين اول اكتشاف تلمفوسايت نشط بلمفوسايت + +131 +00:10:56,600 --> 00:11:01,200 +كوان IGE جالس على سطح المعصّل اول اكتشاف ثانوية + +132 +00:11:01,200 --> 00:11:05,680 +ارتبط بالانتيبادي وصار في cross-linking وصار في + +133 +00:11:05,680 --> 00:11:09,280 +activation وderanulation وطلع ليش الinflammatory + +134 +00:11:09,280 --> 00:11:13,900 +mediators وهذا تأثير الinflammatory mediators هذا + +135 +00:11:13,900 --> 00:11:19,560 +طبعا قد تؤدي إلى الانفلاكتك شوك طبعا هيوفازو + +136 +00:11:19,560 --> 00:11:24,510 +داليشينacute inflammation tissue damage muscle + +137 +00:11:24,510 --> 00:11:28,650 +contraction and bronchoconstriction Inflammatory + +138 +00:11:28,650 --> 00:11:36,050 +mediators في منها mediators زي سموها preformed + +139 +00:11:36,050 --> 00:11:42,090 +preformed mediator وفي اللي هو newly synthesized + +140 +00:11:42,090 --> 00:11:47,450 +mediator طبعا ال preformed جاهزة بتكون مشك يعني + +141 +00:11:47,450 --> 00:11:51,820 +صنعه جاهزة في نفس الالمعصر اللي هو ال بيزوفيل وهي + +142 +00:11:51,820 --> 00:11:56,280 +اللي بتعمل ال first response بينما اللي او ال + +143 +00:11:56,280 --> 00:12:01,440 +immediate reaction يعني بينما ال late phase هو ال + +144 +00:12:01,440 --> 00:12:11,300 +ناتج عن ال mediators اللي اتصمعت upon activation + +145 +00:12:11,300 --> 00:12:15,440 +وطبعا + +146 +00:12:15,440 --> 00:12:18,480 +هي ان اللي هو + +147 +00:12:21,820 --> 00:12:27,640 +الـPrincipal Mediators زي الهستامينهيبرين سيروتنان + +148 +00:12:27,640 --> 00:12:31,200 +وهي تأثيرها increase vascular permeability و + +149 +00:12:31,200 --> 00:12:36,700 +smooth muscle contraction هي ال primary mediators + +150 +00:12:36,700 --> 00:12:42,600 +وفي ناس في كتب بتسميها preformed mediators وفي + +151 +00:12:42,600 --> 00:12:48,020 +اللي هو ال secondary mediators اللي تحت وبرضه هذه + +152 +00:12:48,690 --> 00:12:57,130 +بتعمل الـ late response for this reaction هي الـ + +153 +00:12:57,130 --> 00:13:05,570 +equilibrium prostaglandin and IL-4 و IL-13 هستامين + +154 +00:13:05,570 --> 00:13:10,930 +الهستامين + +155 +00:13:10,930 --> 00:13:17,620 +بيعمل construction of smooth muscle و بيعملبعمل + +156 +00:13:17,620 --> 00:13:21,340 +construction وبالتالي بيصير في weaving التصفيرة مع + +157 +00:13:21,340 --> 00:13:26,280 +النفس بعمل construction of the intestine وبالتالي + +158 +00:13:26,280 --> 00:13:30,640 +بعمل cramp وديارية بعمل vasodilation وزي increase + +159 +00:13:30,640 --> 00:13:38,640 +fluid يعني ادمة وactivate enzyme for tissue tissue + +160 +00:13:38,640 --> 00:13:42,340 +اللي هو breakdown + +161 +00:13:43,840 --> 00:13:48,760 +اليوكترين والبروستاس سايكليين اليوكترين برضه هو + +162 +00:13:48,760 --> 00:13:56,100 +عبارة عن pain inducer بروستاس glanding ملعب ضر + +163 +00:13:56,100 --> 00:14:03,500 +كبير فيه اللي هو ال cloth formation و inhibition + +164 +00:14:03,500 --> 00:14:09,960 +of cloth formation هاي + +165 +00:14:09,960 --> 00:14:15,100 +ال primary yearly mediatorsو هذه الـ Rate Mediator + +166 +00:14:15,100 --> 00:14:19,820 +شوفوا كيف نفخت صار في إيدنا و نفخت هذه ال + +167 +00:14:19,820 --> 00:14:25,700 +immediate effect of long airflow صار في wheezing + +168 +00:14:25,700 --> 00:14:30,640 +وهي ال Late هي + +169 +00:14:30,640 --> 00:14:33,080 +preformed mediator in granules + +170 +00:14:37,610 --> 00:14:41,750 +استامين سايتوكاين تيومان كروس فاكتور ألف عيل وان + +171 +00:14:41,750 --> 00:14:45,950 +عيل ست كيمو أتراكتانتلانيوتروفيل وإزينوفيل إنزايم + +172 +00:14:45,950 --> 00:14:52,590 +زي التريبتيز والكايميز والكتابسينز وthese changes + +173 +00:14:52,590 --> 00:14:55,490 +in connective tissue matrix وبعملوا tissue + +174 +00:14:55,490 --> 00:15:00,670 +breakdown ليكوترين اللي هو secondary mediators + +175 +00:15:00,670 --> 00:15:04,990 +بروستاجلاندين وليكوترين وكل السايتوكاين + +176 +00:15:07,740 --> 00:15:12,440 +بالتالي، تتجمد تجارب التنسيق والمضمون يتحكم على + +177 +00:15:12,440 --> 00:15:14,780 +الاتصال الاجتماعي الاجتماعي الاجتماعي الاجتماعي + +178 +00:15:14,780 --> 00:15:21,860 +الاجتماعي الاجتماعي الاجتماعي الاجتماعي الاجتماعي + +179 +00:15:21,860 --> 00:15:27,360 +الاجتماعي الاجتماعي الاجتماعي الاجتماعي الاجتماعي + +180 +00:15:27,360 --> 00:15:27,640 +الاجتماعي الاجتماعي الاجتماعي الاجتماعي الاجتماعي + +181 +00:15:27,640 --> 00:15:27,680 +الاجتماعي الاجتماعي الاجتماعي الاجتماعي الاجتماعي + +182 +00:15:27,680 --> 00:15:27,680 +الاجتماعي الاجتماعي الاجتماعي الاجتماعي الاجتماعي + +183 +00:15:27,680 --> 00:15:32,400 +الاجتماعي الاجتماعي الاجتما + +184 +00:15:33,690 --> 00:15:38,110 +الأولى كانت تدخل من خلال مصدر ميزوفيل و إيزينوفيل + +185 +00:15:38,110 --> 00:15:48,850 +استعمل إيزينوفيل + +186 +00:15:48,850 --> 00:15:57,150 +لإيزينوفيل + +187 +00:15:57,760 --> 00:16:02,200 +السيطوكاين والميدياتور + +188 +00:16:02,200 --> 00:16:08,140 +الليكوترين بأنواعها بلتليت اكتفات والإيزنوفيل + +189 +00:16:08,140 --> 00:16:13,020 +بإمكانه إعطاء CD4 للجند و 4 بيليمفوس سايت اكتفات + +190 +00:16:13,020 --> 00:16:18,400 +في + +191 +00:16:18,400 --> 00:16:23,900 +معين من ال reaction في localized وفي systemic ال + +192 +00:16:23,900 --> 00:16:27,770 +localizedTarget organ responds to direct contact + +193 +00:16:27,770 --> 00:16:32,750 +with allergen فلو كان في الـGIT بيصير فيه vomiting + +194 +00:16:32,750 --> 00:16:38,590 +و cramping و ديارية و لو كان في ال skin بيصير فيه + +195 +00:16:38,590 --> 00:16:43,750 +rendered inflamed area مع etching و لو كان في + +196 +00:16:43,750 --> 00:16:46,490 +الجهاز التنفسي ال respiratory tract بيصير فيه + +197 +00:16:46,490 --> 00:16:51,350 +airway sensitivity بيتأدي إلى sneezing و rhinitis + +198 +00:16:51,350 --> 00:16:59,240 +أو wheezing و أزمةSystemic بيحصل في Vasodilatation + +199 +00:16:59,240 --> 00:17:02,580 +و Muscle Contraction هذا بيؤدي الى Pronchial + +200 +00:17:02,580 --> 00:17:06,560 +Constriction ادنى and shock هذا هو الانفلاكتك + +201 +00:17:06,560 --> 00:17:10,500 +شوكلر الحقيقي طبعا similar to systemic + +202 +00:17:10,500 --> 00:17:17,020 +inflammation treatment بيأتوا pharmacology بيأتوا + +203 +00:17:17,020 --> 00:17:21,400 +drugs non-steroidal anti-inflammatory اللي هو + +204 +00:17:21,400 --> 00:17:22,520 +كورتيكوستيرويد + +205 +00:17:24,650 --> 00:17:28,070 +اللي هو الـ Non-steroidal بانواعها ثم + +206 +00:17:28,070 --> 00:17:31,810 +Antihistamines to block the histamine receptor + +207 +00:17:31,810 --> 00:17:37,610 +وSteroid الكورتيكوستيرويد وThiophilin أو + +208 +00:17:37,610 --> 00:17:42,270 +Aminophilin أو Epinephrine which prolong increased + +209 +00:17:42,270 --> 00:17:47,630 +cyclic AMP وطبعاً هذا بعمل inhibition ليش لديه + +210 +00:17:47,630 --> 00:17:51,510 +Granulation اليوم بيعملوا Hyposensitization + +211 +00:17:51,510 --> 00:17:53,050 +بيعتبروها immunotherapy + +212 +00:18:10,800 --> 00:18:15,140 +الحاجة الأولانية اما بعمل shifting from t level 2 + +213 +00:18:15,140 --> 00:18:20,060 +to t level 1أو بعمل class watching from IgE ل IgG + +214 +00:18:20,060 --> 00:18:27,660 +وفي كل تل حتين نتخلص من الحساسية طبعا هيه صيفين ال + +215 +00:18:27,660 --> 00:18:35,160 +IgE نزل وطلع ال IgG بداله IgG بعملش حساسية اللي + +216 +00:18:35,160 --> 00:18:39,560 +بعمل حساسية هو ال IgE ليش؟ لأنه ال receptor على + +217 +00:18:39,560 --> 00:18:46,030 +المصل والإذر ال IgG مالهوشهذا هو تجارب الهيبرا + +218 +00:18:46,030 --> 00:18:48,050 +السنسيتيوية الاساسية الاساسية الاساسية الاساسية + +219 +00:18:48,050 --> 00:18:50,610 +الاساسية الاساسية الاساسية الاساسية الاساسية + +220 +00:18:50,610 --> 00:18:52,070 +الاساسية الاساسية الاساسية الاساسية الاساسية + +221 +00:18:52,070 --> 00:18:52,110 +الاساسية الاساسية الاساسية الاساسية الاساسية + +222 +00:18:52,110 --> 00:18:55,790 +الاساسية الاساسية الاساسية الاساسية الاساسية + +223 +00:18:55,790 --> 00:18:55,990 +الاساسية الاساسية الاساسية الاساسية الاساسية + +224 +00:18:55,990 --> 00:18:56,850 +الاساسية الاساسية الاساسية الاساسية الاساسية + +225 +00:18:56,850 --> 00:18:58,010 +الاساسية الاساسية الاساسية الاساسية الاساسية + +226 +00:18:58,010 --> 00:18:58,010 +الاساسية الاساسية الاساسية الاساسية الاساسية + +227 +00:18:58,010 --> 00:18:58,010 +الاساسية الاساسية الاساسية الاساسية الاساسية + +228 +00:18:58,010 --> 00:19:01,460 +الاساسية الاساسية الانتيبادي هم IgM أو IgG بكتبته + +229 +00:19:01,460 --> 00:19:04,180 +مع cell surface molecule و بيصير فيه antibody + +230 +00:19:04,180 --> 00:19:07,760 +-antibody complex بنشطه ال complement على سطح + +231 +00:19:07,760 --> 00:19:12,120 +الخلية فبكسر الخلية فسيصبح Hemolysis طبعا + +232 +00:19:12,120 --> 00:19:15,560 +inappropriate response في الوضع الطبيعي it + +233 +00:19:15,560 --> 00:19:19,580 +eliminate foreign cells في الوضع الطبيعي ممكن + +234 +00:19:19,580 --> 00:19:23,880 +يتكون antibody أو auto-antibodyفرصة في انتجن ويعمل + +235 +00:19:23,880 --> 00:19:29,440 +auto immunity disease وبالتالي ال antigen ال + +236 +00:19:29,440 --> 00:19:37,260 +antibody should be tolerated وهي الميكانيزم انتجن + +237 +00:19:37,260 --> 00:19:42,740 +دخل على موجود على سطح الخلية سوري antibody تكون له + +238 +00:19:42,740 --> 00:19:47,600 +قوات ارتبط فيه اما بينشط ال complement وبيعمل + +239 +00:19:47,600 --> 00:19:51,790 +membrane attack complex وبيكسرهاوإما بعمل Antibody + +240 +00:19:51,790 --> 00:19:54,670 +Dependent Cell Mediated Cytotoxicity لأن + +241 +00:19:54,670 --> 00:19:58,410 +الانتيبادي موجود و ال Fc Portion فالد وبالتالي + +242 +00:19:58,410 --> 00:20:01,270 +يقيله ال Fc Portion ويجيجي يقيله ال Receptor على + +243 +00:20:01,270 --> 00:20:10,470 +سطح عدد كتير من الفاجوسيتكسيل والانكيسم فبتعمل + +244 +00:20:10,470 --> 00:20:15,050 +Destruction للخلية وإما بعمل Obsonization ومحصلته + +245 +00:20:15,050 --> 00:20:18,390 +أيضا فاجوسيتوسيز في جميع الحالات بصير Cell + +246 +00:20:18,390 --> 00:20:19,550 +Destruction + +247 +00:20:21,660 --> 00:20:27,480 +عنصر على ذلك ناخد مثال على الـ autoimmunity مثال + +248 +00:20:27,480 --> 00:20:30,940 +المشهور اللي هو goodpastors syndrome هو برعنة + +249 +00:20:30,940 --> 00:20:33,420 +الانتجر بيكون هو برعنة Alpha تلاتة chain of + +250 +00:20:33,420 --> 00:20:36,580 +basement membrane للكولاجين موجود على الكدن + +251 +00:20:36,580 --> 00:20:43,540 +واللنجة متكون Antibody للAlpha تلاتة اللي هو chain + +252 +00:20:43,540 --> 00:20:47,620 +basement membraneو يوم ما يحصل cross-linking مع + +253 +00:20:47,620 --> 00:20:51,600 +الـ receptor و الـ cytotoxic cell أو على سطح الخلق + +254 +00:20:51,600 --> 00:20:55,560 +الـ cytotoxic cell بنشط monocyte و neutrophil و + +255 +00:20:55,560 --> 00:20:59,480 +mesophil طبعا بتفرز كيموكاين which recruit more + +256 +00:20:59,480 --> 00:21:03,900 +neutrophil و طبعا this will lead to self tissue + +257 +00:21:03,900 --> 00:21:13,860 +destruction و هي صورة ال lung كيف صار لها + +258 +00:21:13,860 --> 00:21:20,000 +infarctionمثال آخر اللي هو for an antigen طبعا في + +259 +00:21:20,000 --> 00:21:23,960 +هذا الحالة يوم ما تنقل incompatible blood through + +260 +00:21:23,960 --> 00:21:28,760 +transfusion بيصير transfusion reaction وهي بيصير + +261 +00:21:28,760 --> 00:21:33,780 +اللي هو incompatibility طبعا كلنا بنعرف أنه فصيلة + +262 +00:21:33,780 --> 00:21:37,640 +A عندها انت B وفصيلة B عندها انت A فأي خلل في نقل + +263 +00:21:37,640 --> 00:21:42,800 +أي فصيلة بيدينا اللي هو بيكون فيه strong antibody + +264 +00:21:42,800 --> 00:21:47,090 +جاعت بيستنى ال antigen فهو IgMفيرتبط فيه وبيعمل + +265 +00:21:47,090 --> 00:21:53,910 +اتنينيونيومولاتيكي reaction drugs أيضا ممكن يصير + +266 +00:21:53,910 --> 00:21:58,050 +في نقشة نفس الحكاية ان ال drug يقعد على سطح يرتبط + +267 +00:21:58,050 --> 00:22:04,190 +بانتيجينات على سطح خلايا معينة منها ال RBCsفطبعا + +268 +00:22:04,190 --> 00:22:08,530 +ال drugs بيكون في الوضع الأولاني هو فت فت طبعا + +269 +00:22:08,530 --> 00:22:13,890 +بيصير بيعتبر Epitopes بيعتبر Heptane لما بيقعد على + +270 +00:22:13,890 --> 00:22:18,350 +السطح الخلية بيرتبط ببروتينات في ال membrane بيكبر + +271 +00:22:18,350 --> 00:22:21,150 +و بيصير immunogen بتكوّله antibody اللي بيقدر + +272 +00:22:21,150 --> 00:22:27,970 +يتفاعل مع مين مع ال antigen مع ال Heptane و ال + +273 +00:22:27,970 --> 00:22:35,960 +protein اللي ارتبط فيهالـ .. طبعا ايضا + +274 +00:22:35,960 --> 00:22:41,020 +ممكن الـ Antibody اللى بتكون هو عبارة عن IGG IGG + +275 +00:22:41,020 --> 00:22:45,980 +مايقدرش يعمل تكسير للـ Direct Hemolysis فبالتالي + +276 +00:22:45,980 --> 00:22:51,340 +ممكن خلية تتكسر اما Through ADCC واما Through + +277 +00:22:51,340 --> 00:22:56,960 +Phagocytosis Drug induced thrombocytopenic pair + +278 +00:22:56,960 --> 00:23:04,040 +برا نفس الحكاية تكونAntibody للـ Platelet و + +279 +00:23:04,040 --> 00:23:08,960 +Antibody للـ Platelet وبالتالي صار في Optionized + +280 +00:23:08,960 --> 00:23:14,820 +Platelet طبعا هذه اسمها Destruction by + +281 +00:23:14,820 --> 00:23:19,000 +Phagocytosis + +282 +00:23:19,000 --> 00:23:22,860 +Hepatic + +283 +00:23:22,860 --> 00:23:26,380 +disease of new born طبعا الأرشين compatibility كل + +284 +00:23:26,380 --> 00:23:30,950 +كتير في حدوثة أن ال motherRH negative mother لما + +285 +00:23:30,950 --> 00:23:35,430 +تكون حاملة ب RH positive baby طبعا في ال baby + +286 +00:23:35,430 --> 00:23:39,530 +الأولاني بيعدي لكن during delivery شوية أنتيجينات + +287 +00:23:39,530 --> 00:23:43,390 +ل RH positive بخش على ال mother blood فبتكونله + +288 +00:23:43,390 --> 00:23:47,150 +antibody منه IGG في ال second pregnancy it can + +289 +00:23:47,150 --> 00:23:54,810 +cross the placenta وبيهاجم ال baby second baby هذا + +290 +00:23:54,810 --> 00:23:59,590 +هوهذه أمثلة عن الـ Hypersensitivity Type-2 + +291 +00:23:59,590 --> 00:24:05,470 +Hypersensitivity Reaction Type-3 ماذا يحصل؟ ما + +292 +00:24:05,470 --> 00:24:10,230 +يحصل في الـ Immune Complexes Immune Complexes + +293 +00:24:10,230 --> 00:24:16,070 +Formation ما يحصل؟يتكيّن Antigen Antibody Reaction + +294 +00:24:16,070 --> 00:24:19,270 +بكميات كبيرة بسبب Deposition على الـTissue وهو + +295 +00:24:19,270 --> 00:24:24,370 +طبعاً هذا بنشطنا بيجي يتكلم داخل الـCell + +296 +00:24:24,370 --> 00:24:28,210 +الـPhagocytic Cell بيجي يتخلصنا منه لكن ما بتقدر + +297 +00:24:28,210 --> 00:24:33,970 +فتعمل Degranulation وTissue Damage Payer هي سوليب + +298 +00:24:33,970 --> 00:24:40,160 +الانتجين الانتبادي IGG مع الـComplementانتجار غير + +299 +00:24:40,160 --> 00:24:43,060 +مناسب في الوضع الطبيعي الانتيجين انتجار غير مناسب + +300 +00:24:43,060 --> 00:24:45,640 +في الوضع الطبيعي الانتيجين انتجار بيساعد في + +301 +00:24:45,640 --> 00:24:49,540 +الفلوسيتوسيز وكليرانس الهيار أو الانتيجين لكن + +302 +00:24:49,540 --> 00:24:56,340 +بمجرد أن يكون هناك عدد كبير من الكمبليكسيز يحصل + +303 +00:24:56,340 --> 00:25:00,560 +فيه تشيو دامج طبعا + +304 +00:25:00,560 --> 00:25:05,430 +تابع ثلاثة بيط وسموه others reactionهي الـ + +305 +00:25:05,430 --> 00:25:10,050 +Previously Synthesized Host يمثل فيه Antigen + +306 +00:25:10,050 --> 00:25:13,670 +Exposure to Specific Site إما بإنهيليشن أو إنجيكشن + +307 +00:25:13,670 --> 00:25:19,450 +بيتكون Antibody من نوع IgG مع الانتجين فبيكون IgG + +308 +00:25:19,450 --> 00:25:24,890 +Antigen Complex طبعا هذا إما بنشط الكمليمنت تكون + +309 +00:25:24,890 --> 00:25:31,190 +C3A C5A دي are Anaflatoxin and Chemotactic Agent + +310 +00:25:31,190 --> 00:25:38,660 +ويعملوا Membrane Attack Complexأو انه بتكون ال IGG + +311 +00:25:38,660 --> 00:25:47,280 +و بيعمل ايش بيعمل optionization لليكوسايد و هي + +312 +00:25:47,280 --> 00:25:54,220 +بالتالي it will be phagocytosis or by releasing of + +313 +00:25:54,220 --> 00:26:01,780 +lytic enzyme secretion هذا + +314 +00:26:01,780 --> 00:26:07,040 +هيطبعا هى الانتيجن تكونله antibody في blood + +315 +00:26:07,040 --> 00:26:12,440 +vessels هى فصار فى antibody-antibody complex + +316 +00:26:12,440 --> 00:26:19,780 +انتيجن antibody-antibody complex ممكن ينشطلنا في + +317 +00:26:19,780 --> 00:26:23,940 +agostatic cell تيجي تخلصنا منه و بتقدرش فبتعمل + +318 +00:26:23,940 --> 00:26:26,740 +degranulation فى منطقة الحدث وبالتالي بيصير فى + +319 +00:26:26,740 --> 00:26:28,440 +tissue damaged + +320 +00:26:32,260 --> 00:26:35,040 +Antigen-antibody-immune-complex الـ IgG-mediated + +321 +00:26:35,040 --> 00:26:39,120 +immune-complex disease كميات كبيرة من الانتجين + +322 +00:26:39,120 --> 00:26:44,220 +والانتبادي تشكل كمبليكسات في الدم، إذا لم يتم + +323 +00:26:44,220 --> 00:26:47,980 +إيقافها، يمكن أن تدفعها إلى الورق أو الرقص ويؤثر + +324 +00:26:47,980 --> 00:26:52,720 +على الإنفلام. طبعاً هذا هي المحصلة + +325 +00:26:55,390 --> 00:26:59,690 +Antigen Antibody ده هو Immune Complex اتكون نشطت + +326 +00:26:59,690 --> 00:27:04,370 +انها عدة خلايا الـ Platelet عملت من Micro from با + +327 +00:27:04,370 --> 00:27:09,590 +عي بيزوفيل نشطته عملت Vasoactive Amine وبالتالي + +328 +00:27:09,590 --> 00:27:14,990 +عملت Vasodilator وAedema ال complement في انها C3A + +329 +00:27:14,990 --> 00:27:22,430 +C5A بتتكون و هتقول عبارة عن Chemotactic Factor + +330 +00:27:22,430 --> 00:27:27,770 +و في نفس الوجود انا اعرف لها Toxinطبعا هي ال C5A + +331 +00:27:27,770 --> 00:27:30,850 +نشطة الدنيوتروفيل فهي جت تخلصنا من ال complex + +332 +00:27:30,850 --> 00:27:34,410 +بتقدرش فبتعمل degranulation بيسموها frustrated + +333 +00:27:34,410 --> 00:27:39,430 +phagocytosis ليش؟ مفروض تاكل فماقدرتش تاكل فعملت + +334 +00:27:39,430 --> 00:27:44,170 +digestion outside the cell و بيسموها اللي هو + +335 +00:27:44,170 --> 00:27:49,530 +frustrated phagocytosis طبعا + +336 +00:27:51,390 --> 00:27:55,830 +أو الـ Granule Contents عندما يخرج من الخلية يعمل + +337 +00:27:55,830 --> 00:28:01,010 +تشيو دامج هذا + +338 +00:28:01,010 --> 00:28:06,090 +هو كما تشاهدون هنا يوجد اميون كومبليكس هنا طبعا + +339 +00:28:06,090 --> 00:28:09,250 +الاميون كومبليكس نشطت نشطت نيوتروفيل يأتي تخلصنا + +340 +00:28:09,250 --> 00:28:15,270 +منها و لا تريدها فتعمل تشيو دامج تعمل تشيو دامج + +341 +00:28:15,270 --> 00:28:18,350 +cell membrane damage + +342 +00:28:20,580 --> 00:28:27,240 +نفس الحكاية بتعمل Vasculitis هذا في حالات اللي هو + +343 +00:28:27,240 --> 00:28:30,560 +ال autoimmune أو ال immune complex mediated tissue + +344 +00:28:30,560 --> 00:28:35,460 +injury type 3 immune complex polymorphic nuclear + +345 +00:28:35,460 --> 00:28:39,720 +and macrophage bind to immune complexes via FC + +346 +00:28:39,720 --> 00:28:43,140 +receptor and phagocytase the complex لكن إذا + +347 +00:28:43,140 --> 00:28:50,800 +ماقدرتشبالتالي يمكن أن يسبب انفلامية من خلال + +348 +00:28:50,800 --> 00:28:58,240 +اكتبار كومplement بطلعة C3A C4A C5A ويتعمل فرسترات + +349 +00:28:58,240 --> 00:29:02,860 +فاقوسييتز فرسترات فاقوسييتز هي كيفينيوتر فيها + +350 +00:29:02,860 --> 00:29:06,600 +ماكروفيش ممكن أن يفرسترات فاقوسييتز + +351 +00:29:09,500 --> 00:29:12,080 +هو الـ Degranulate in the area of immune complex + +352 +00:29:12,080 --> 00:29:15,600 +deposition and trigger inflammation يعني انا + +353 +00:29:15,600 --> 00:29:22,460 +unable to eat فتحاول تدخل خارج الجسم مثال + +354 +00:29:22,460 --> 00:29:30,200 +حقيقي برضه على اللي هو ال localized + +355 +00:29:32,130 --> 00:29:36,330 +الخاصة التالية بتسمى + +356 +00:29:36,330 --> 00:29:41,570 +Extrinsic Allergic Alveolitis هو بيصيب الفارمورز + +357 +00:29:41,570 --> 00:29:48,270 +لنجه هدى يدخلوا فيها مفلك أكتينوموائيسيد موجودة في + +358 +00:29:48,270 --> 00:29:53,750 +الـdry and dusty moldy hay بيساولها inhalation by + +359 +00:29:53,750 --> 00:29:57,570 +large amount طبعا ال initial exposure بده يعمل + +360 +00:29:57,570 --> 00:30:02,000 +يكون ان IGG antibody about repeated exposureالـ + +361 +00:30:02,000 --> 00:30:06,820 +Antibody موجود و طبعا يحصل فيه Immune Complexes في + +362 +00:30:06,820 --> 00:30:13,620 +اللغة و Pneumonitis و Alveolitis Generalized + +363 +00:30:13,620 --> 00:30:18,900 +reaction هي Systemic Exposure to Antigen كون Large + +364 +00:30:18,900 --> 00:30:24,700 +amount of IgG Small IgG مع الانتجين Complexes + +365 +00:30:24,700 --> 00:30:28,460 +Difficult to clear circulate and become deposited + +366 +00:30:28,460 --> 00:30:38,030 +all over the bodyطبعا تصبح تشيو دمج بسبب اكتفيش + +367 +00:30:38,030 --> 00:30:41,950 +فجوسيتكسل + +368 +00:30:41,950 --> 00:30:46,970 +هاي مثال اخر serum sickness طبعا انا انترالينس او + +369 +00:30:46,970 --> 00:30:50,450 +انترالينس او انترالينس او انترالينس او انترالينس + +370 +00:30:50,450 --> 00:30:50,450 +او انترالينس او انترالينس + +371 +00:30:56,350 --> 00:31:00,570 +سم حققناه في حصان أخدنا بعد هيكا ال serum تبع + +372 +00:31:00,570 --> 00:31:04,530 +الحصان و طلعنا ال antibody تبعه هذا ممكن يكون ك + +373 +00:31:04,530 --> 00:31:14,410 +vaccine طبعا يوم ما أبقى يوم + +374 +00:31:14,410 --> 00:31:18,890 +ما ناخده و نحقنه في إنسان طبعا هذا ممكن الإنسان + +375 +00:31:18,890 --> 00:31:23,710 +طبعا اللي ماخد ال venom هيصير في immune complexes + +376 +00:31:23,710 --> 00:31:28,280 +و هتترسب على ال joint و skin و kidneyو تعمل مشاكل + +377 +00:31:28,280 --> 00:31:33,720 +هاي ال serum sickness هاي ال free antigen في الأول + +378 +00:31:33,720 --> 00:31:40,280 +بعد ذلك طبعا صار في immune complexes و هاي ال + +379 +00:31:40,280 --> 00:31:44,800 +symptoms و بدت تتكون large amount of antigen such + +380 +00:31:44,800 --> 00:31:46,960 +as injection و free serum + +381 +00:31:51,290 --> 00:31:56,630 +لوكاليز ديزييت ترسّب الimmune complexes على الجون + +382 +00:31:56,630 --> 00:32:00,470 +بيعمل inflammation و arthritis وعالكدنى بيعمل + +383 +00:32:00,470 --> 00:32:05,980 +glomerulonephritisAuto immunity مثال آخر SLE + +384 +00:32:05,980 --> 00:32:10,480 +Systemic Leukocytic Rheumatosis في اللي بيصير طارد + +385 +00:32:10,480 --> 00:32:15,380 +الإنسان للشمس Ultraviolet light أو cell death و هي + +386 +00:32:15,380 --> 00:32:21,660 +بيصير في impaired apoptic cell clearance لأن هذا + +387 +00:32:21,660 --> 00:32:24,680 +بيؤدي إلى نيكلار كروتين مع DNA exposed to the + +388 +00:32:24,680 --> 00:32:31,420 +circulation طبعا Auto antibody بتكون لهمالـ B-cell + +389 +00:32:31,420 --> 00:32:36,920 +priming زي الـ class switching to IgG هيعمل .. + +390 +00:32:36,920 --> 00:32:40,580 +هيرتبط معاياش مع الـ Antigen ويعمل Immune + +391 +00:32:40,580 --> 00:32:47,160 +Complexes هي نفس الحكاية Circulating B lymphocyte + +392 +00:32:47,160 --> 00:32:54,220 +بترتبط بطبيعياش بـ Antigenماشي تاخدت قدمته ل T + +393 +00:32:54,220 --> 00:32:58,680 +lymphocyte نشطتها كونت Antibody ال Antibody ارتبط + +394 +00:32:58,680 --> 00:33:02,400 +في اللي هيش ال Antigen كون Immune Complexes إجت + +395 +00:33:02,400 --> 00:33:11,980 +الفاجوسة تكسل و طبعا ماقدرتش تخلصنا منه فبصير فيه + +396 +00:33:11,980 --> 00:33:19,580 +Deposition و Injury at site of infectionوحصلة + +397 +00:33:19,580 --> 00:33:25,480 +tissue damage type 4 hypersensitivity reaction هو + +398 +00:33:25,480 --> 00:33:30,120 +الـ delete type hypersensitivity reaction وهذا + +399 +00:33:30,120 --> 00:33:35,060 +يتمثل بتنشيط تيل بار واحد مع cytotoxic CD8-T + +400 +00:33:35,060 --> 00:33:39,840 +lymphocyte الـ cytokine اللي بطلع من تيل بار واحد + +401 +00:33:39,840 --> 00:33:44,160 +بنشطلنا الماكرافيج والماكرافيج بتعمل delete type + +402 +00:33:44,160 --> 00:33:49,390 +hypersensitivity reactionT برواحة cell release + +403 +00:33:49,390 --> 00:33:53,690 +cytokine to activate macrophage بيعمل inflammation + +404 +00:33:53,690 --> 00:33:57,830 +and tissue damage Continued macrophage activation + +405 +00:33:57,830 --> 00:34:02,010 +بيؤدي ل chronic inflammation و هذا بيؤدي ل tissue + +406 +00:34:02,010 --> 00:34:08,110 +lesion و scarring و granuloma ال reaction ممكن + +407 +00:34:08,110 --> 00:34:12,350 +يكون delete because delete type hypersensitivity + +408 +00:34:12,350 --> 00:34:19,670 +response بيوصل طبعا ال reactionحدوثه بعد 24 إلى 72 + +409 +00:34:19,670 --> 00:34:26,430 +ساعة after exposure rather than minutes يعني + +410 +00:34:26,430 --> 00:34:30,950 +التفارق بيحصل بعد 24 إلى 72 ساعة player T helper + +411 +00:34:30,950 --> 00:34:35,130 +one macrophage normally necessary immune + +412 +00:34:35,130 --> 00:34:39,710 +protection against intracellular pathogen لكن if + +413 +00:34:39,710 --> 00:34:42,090 +prolonged response lead to extensive tissue + +414 +00:34:42,090 --> 00:34:47,860 +destructionمرضه بيتمثل بأكتر من Stage أول Stage + +415 +00:34:47,860 --> 00:34:51,700 +اللي هو Sensitization أيش اللي بيصير؟ والله يتيهي + +416 +00:34:51,700 --> 00:34:54,040 +البرامو .. مين مولي تيهي البراسيل؟ يعني إيش؟ يعني + +417 +00:34:54,040 --> 00:34:58,580 +شافت ال antigen قبل هيك طب إيش بتعمل؟ قالوا + +418 +00:34:58,580 --> 00:35:03,120 +against delayed type hypersensitivity antigen اه + +419 +00:35:03,120 --> 00:35:08,480 +Renated شو اللي خلاها الست اتنشط ب Identity Cell + +420 +00:35:08,480 --> 00:35:12,140 +during Sensitization Stageالعزيزة الـ T-Helper + +421 +00:35:12,140 --> 00:35:14,260 +cell can activate macrophage and trigger + +422 +00:35:14,260 --> 00:35:19,280 +inflammatory response ايوة first exposure انتجين + +423 +00:35:19,280 --> 00:35:27,200 +presenting cell أخدت الانتجين قدمته مرتبط بالامر C + +424 +00:35:27,200 --> 00:35:32,620 +-molecule ل T cell اللي هو CD4 T-Helper cell طبعا + +425 +00:35:32,620 --> 00:35:37,860 +في هذه الحالة صار مشتقت و إدتني T-Helper واحد + +426 +00:35:39,560 --> 00:35:45,640 +تقريبا 1 تقريبا 1 تقريبا + +427 +00:35:45,640 --> 00:35:51,320 +1 + +428 +00:35:51,320 --> 00:35:53,120 +تقريبا 1 تقريبا 1 تقريبا 1 تقريبا 1 تقريبا 1 + +429 +00:35:53,120 --> 00:35:53,240 +تقريبا 1 تقريبا 1 تقريبا 1 تقريبا 1 تقريبا 1 + +430 +00:35:53,240 --> 00:35:53,760 +تقريبا 1 تقريبا 1 تقريبا 1 تقريبا 1 تقريبا 1 + +431 +00:35:53,760 --> 00:35:54,440 +تقريبا 1 تقريبا 1 تقريبا 1 تقريبا 1 تقريبا 1 + +432 +00:35:54,440 --> 00:35:54,440 +تقريبا 1 تقريبا 1 تقريبا 1 تقريبا 1 تقريبا 1 + +433 +00:35:54,440 --> 00:35:54,440 +تقريبا 1 تقريبا 1 تقريبا 1 تقريبا 1 تقريبا 1 + +434 +00:35:54,440 --> 00:36:03,600 +تقريبا 1 تقريبا 1 تقريبا 1 تقريبا 1 تق + +435 +00:36:05,250 --> 00:36:13,450 +سيكون عارف و تيهيلبر وان ميموري مستعملت تفرش + +436 +00:36:13,450 --> 00:36:16,650 +سايتوكاين ذاتي الجامعة انتفارون تيومون اكسوس + +437 +00:36:16,650 --> 00:36:23,690 +فاكتور ألف وبيتا وتعمل تشويه دمج وإنفلاميشين ال + +438 +00:36:23,690 --> 00:36:27,570 +IL2 أيضا يستعمل تشويه سايتوكسك تيهيلبر وان + +439 +00:36:27,570 --> 00:36:34,490 +بالإضافة تيهيلبر وان كيموكاين 4 مايكروفيج مستعملت + +440 +00:36:35,910 --> 00:36:38,550 +العيال التلاتة GMC-SF يمكن أن تزداد ميكروفيج مونو + +441 +00:36:38,550 --> 00:36:40,470 +سايت ميكروفيج ميكروفيج ميكروفيج ميكروفيج ميكروفيج + +442 +00:36:40,470 --> 00:36:41,530 +ميكروفيج ميكروفيج ميكروفيج ميكروفيج ميكروفيج + +443 +00:36:41,530 --> 00:36:44,650 +ميكروفيج ميكروفيج ميكروفيج ميكروفيج ميكروفيج + +444 +00:36:44,650 --> 00:36:45,670 +ميكروفيج ميكروفيج ميكروفيج ميكروفيج ميكروفيج + +445 +00:36:45,670 --> 00:36:45,690 +ميكروفيج ميكروفيج ميكروفيج ميكروفيج ميكروفيج + +446 +00:36:45,690 --> 00:36:52,590 +ميكروفيج ميكروفيج ميكروفيج ميكروفيج ميكروفيج + +447 +00:36:52,590 --> 00:36:56,450 +ميكروفيج + +448 +00:36:56,450 --> 00:37:03,330 +ميكرو + +449 +00:37:05,470 --> 00:37:10,350 +أي ساكند اكسبوجر من موري تير برسيل حتى ولا افكتور + +450 +00:37:10,350 --> 00:37:13,590 +تير برسيل with secret cytokine, inflammatory + +451 +00:37:13,590 --> 00:37:19,330 +cytokine, chemokine for phagocytes recruitment شره + +452 +00:37:19,330 --> 00:37:23,290 +الجامعة انترفيرون more activated macrophage to + +453 +00:37:23,290 --> 00:37:27,210 +exposure sitesAt exposure sites mostly non + +454 +00:37:27,210 --> 00:37:31,710 +-specific inflammatory cell زي الـ macrophage و + +455 +00:37:31,710 --> 00:37:36,050 +few antigen specific cell زي الـ T lymphocytes are + +456 +00:37:36,050 --> 00:37:40,030 +present هي + +457 +00:37:40,030 --> 00:37:46,930 +الـ T البربونة شتت لنا macrophage طبعا هذا يوم + +458 +00:37:46,930 --> 00:37:51,190 +يحصل في chronic activation للميكروفاج تعمل ما يسمى + +459 +00:37:51,190 --> 00:37:56,900 +بالـ granuloma اللي هوFormation أيها مليانة بـ + +460 +00:37:56,900 --> 00:38:03,660 +macrophage محاطة بـ T-cell بكتيريا لا يمكن ان تكون + +461 +00:38:03,660 --> 00:38:10,020 +اختلطت تكون فلورا جرانيولوما Formation وهي طبعا في + +462 +00:38:10,020 --> 00:38:14,960 +continuous macrophage ذاتي البروان اكتفيشن بس هذا + +463 +00:38:14,960 --> 00:38:19,560 +بيقدي الهيلتك انزعيم و tissue damage اي جرانيولوما + +464 +00:38:19,560 --> 00:38:20,920 +Formation + +465 +00:38:24,330 --> 00:38:28,590 +كمتك درماتيتس طبعا مثال آخر من أمثلة delayed type + +466 +00:38:28,590 --> 00:38:34,130 +hypersensitivity طبعا هذا في عدة أمثلة منها المثال + +467 +00:38:34,130 --> 00:38:41,890 +الأول هو poison أويج هو عبارة عن classic type شو + +468 +00:38:41,890 --> 00:38:45,650 +اللي بيصير طبعا هذا ال poison موجود على أوراق بعض + +469 +00:38:45,650 --> 00:38:53,140 +النباتات على شكل oil يوم ما حد يمسكهطبعاً بيصيله + +470 +00:38:53,140 --> 00:38:57,140 +absorption by skin تتلقى فى antigen-presenting + +471 +00:38:57,140 --> 00:39:00,740 +cell و بتقدمه لتيل بر واحد و بتعمل sensitization + +472 +00:39:00,740 --> 00:39:06,580 +upon secondary explosion تيل بر واحد memory cell + +473 +00:39:06,580 --> 00:39:11,780 +بتنشط و بتعمل delayed type hypersensitivity هى ده + +474 +00:39:11,780 --> 00:39:19,700 +هى هى النباتات هى ال poison هى فيه toxicodendron + +475 +00:39:19,700 --> 00:39:27,470 +materialبنتا ديكا كاتيكول substance تحتوي على هذه + +476 +00:39:27,470 --> 00:39:31,410 +المادة بتخش can be absorbed تتلقفها تجيب + +477 +00:39:31,410 --> 00:39:35,050 +presenting cell تقدمها ل T lymphocyte اللي بتبدأ + +478 +00:39:35,050 --> 00:39:41,730 +تفرز هذا هي cytokine بتنشط اللي هو ال macro phase + +479 +00:39:41,730 --> 00:39:48,770 +وطبعا بيصير فيه tissue damageمثلًا آخر اللي هو الـ + +480 +00:39:48,770 --> 00:39:51,430 +small molecules اللي موجودة في اللواعي الداخلية زي + +481 +00:39:51,430 --> 00:39:56,050 +النكل والكروم أيضًا can act as a haptin الجسم + +482 +00:39:56,050 --> 00:39:59,850 +بيمطسها ترتبط ببروتينات الجسم من داخلها وبتصير + +483 +00:39:59,850 --> 00:40:02,350 +immunogen بتتلقى في antigen presenting cell + +484 +00:40:02,350 --> 00:40:06,230 +وبتقدمها ل T cell طبعًا ال T cell هتتنشط ي البروان + +485 +00:40:06,230 --> 00:40:11,530 +تتنشط وتنشط لنا ال macro phase اللي هتعمل اللي هو + +486 +00:40:11,530 --> 00:40:16,530 +tissue damage ال lips ال gloves + +487 +00:40:17,560 --> 00:40:21,600 +لفظ اللي مليانة باودر نفس الحكاية الباودر can be + +488 +00:40:21,600 --> 00:40:25,840 +absorbed by skin و بيخش على شكل هابتين برتبط + +489 +00:40:25,840 --> 00:40:31,000 +بالبروتينات تحور إليها immunogen بنشط طبعا تاخدوا + +490 +00:40:31,000 --> 00:40:34,040 +antigen presenting cell و بنشطتيه البروان اللي + +491 +00:40:34,040 --> 00:40:36,340 +بتنشط microphage و بتعمل tissue damage + +492 +00:40:39,270 --> 00:40:43,190 +أيضا مثال آخر الـ Mantox test أو الـ Mycobacterial + +493 +00:40:43,190 --> 00:40:46,650 +tuberculosis طبعا هذا purified protein derivative + +494 +00:40:46,650 --> 00:40:49,810 +بيحقن تحت الجلد و بنستنى عليه اربع و عشرين ات + +495 +00:40:49,810 --> 00:40:52,530 +تمانى و اربعين ساعة اتمانى اربعين اتنين و سبعين + +496 +00:40:52,530 --> 00:40:57,450 +sorry ساعة و بنشوف اذا كان صار wheel and flare + +497 +00:40:57,450 --> 00:41:00,670 +reaction او بيسموه swelling سهل تشوف اذا في + +498 +00:41:00,670 --> 00:41:03,350 +swelling معناته في previous exposure مافيش + +499 +00:41:03,350 --> 00:41:08,840 +swelling معناته فيش previous exposureطبعا هذه + +500 +00:41:08,840 --> 00:41:14,300 +الأمثلة عن الـDelete Type Hypersensitivity كلها + +501 +00:41:14,300 --> 00:41:18,960 +وشو بتعمل Clinical Sign وHistological Feature هذه + +502 +00:41:18,960 --> 00:41:24,620 +طبعا نشرة عن الـDelete Type Hypersensitivity + +503 +00:41:24,620 --> 00:41:31,380 +وملاقتها بتجه البروان هذه الأربع أنواع ملخصين وكل + +504 +00:41:31,380 --> 00:41:35,180 +نوع مين بتنشط فيه وإيش ال clinical manifestation + +505 +00:41:35,180 --> 00:41:41,880 +اللي بتصير أثناءهوبهيك بنكون خلصنا أول section من + +506 +00:41:41,880 --> 00:41:45,000 +هذه المحاضرة وهو Hypersensitivity + diff --git a/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/QNU0sgyEFEM_postprocess.srt b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/QNU0sgyEFEM_postprocess.srt new file mode 100644 index 0000000000000000000000000000000000000000..3a91def80c1cc6703607df90f4a86d246665ee41 --- /dev/null +++ b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/QNU0sgyEFEM_postprocess.srt @@ -0,0 +1,1040 @@ +1 +00:00:01,650 --> 00:00:06,350 +بسم الله الرحمن الرحيم اليوم ان شاء الله هحكي في + +2 +00:00:06,350 --> 00:00:14,530 +المحاضرة رقم خمسة وهي بعنوان antigen من الصورة زى + +3 +00:00:14,530 --> 00:00:20,610 +ما انتوا شايفين ال antigen بياخد particular + +4 +00:00:20,610 --> 00:00:25,370 +structure اللى على سطحه ممكن يكون different + +5 +00:00:25,370 --> 00:00:28,310 +Epitopes شايفين Epitopes كل هذه عبارة عن Epitopes + +6 +00:00:28,310 --> 00:00:33,450 +اوما تسمى بالـ Antigenic Determinant اللي هي أماكن + +7 +00:00:33,450 --> 00:00:37,270 +ارتباط الـ Antibody فيها طيب نيجي نخش على المحاضرة + +8 +00:00:37,270 --> 00:00:42,950 +و نشوف ايش التعريفات بالمناسبة معظم هذه المحاضرة + +9 +00:00:42,950 --> 00:00:50,030 +هي عبارة عن تعريفات و مصطلحات منعية فال Antigen هي + +10 +00:00:50,030 --> 00:00:55,630 +عبارة عن أي مادة ت induce with the immune response + +11 +00:00:55,630 --> 00:01:00,900 +و بتتفاعل مع نواتج هذا ال immune responseوبالتالي + +12 +00:01:00,900 --> 00:01:04,640 +الانتيجن هي أصلها جاي من antibody generation + +13 +00:01:04,640 --> 00:01:08,680 +ماخدين أول أحرف من ال antibody generation طلعت + +14 +00:01:08,680 --> 00:01:16,400 +الكلمة antigen واليوم ثبت على أن الانتيجن لا يحفظ + +15 +00:01:16,400 --> 00:01:24,360 +تصنيع antibody فقط وإنما يحفظ تصنيع خلايا أخرى ضمن + +16 +00:01:24,360 --> 00:01:28,830 +اللي هو ال immune response اللي بطلعوبالتالي + +17 +00:01:28,830 --> 00:01:34,190 +Modern definition بيقول ان ال immune response هو + +18 +00:01:34,190 --> 00:01:37,070 +عبارة عن all substances that can be recognized by + +19 +00:01:37,070 --> 00:01:41,450 +adaptive immune response ال immunogen هو عبارة عن + +20 +00:01:41,450 --> 00:01:46,810 +أي مادة قادرة على تحفيز ال immune response بينما + +21 +00:01:46,810 --> 00:01:50,010 +ال antigen هو عبارة عن أي مادة قادرة على + +22 +00:01:58,460 --> 00:02:04,040 +الإميونوجين هو أي مادة قادرة على تحفيز جهاز + +23 +00:02:04,040 --> 00:02:07,740 +المناعة بينما الانتجين هي أي مادة قادرة على + +24 +00:02:07,740 --> 00:02:14,280 +التفاعل مع منتوج ال product of immune response + +25 +00:02:14,280 --> 00:02:20,680 +بينجوسين الانتيبادي أو الـsensitized cell لكن ليس + +26 +00:02:20,680 --> 00:02:25,080 +شرط ان يعمل immune response وبالتالي كل إميونوجين + +27 +00:02:25,080 --> 00:02:29,750 +هو عبارة عن انتجنليس كل انتجين هو عبارة عن + +28 +00:02:29,750 --> 00:02:34,630 +immunogen ال + +29 +00:02:34,630 --> 00:02:42,030 +tolerogen هو عبارة عن انتجين اللي لما بدخل الجسم + +30 +00:02:42,030 --> 00:02:47,770 +بيصير له استجابة منعية that invoke a specific + +31 +00:02:47,770 --> 00:02:51,310 +immune non responsiveness يعني عدم استجابة منعية + +32 +00:02:51,310 --> 00:02:56,310 +السبب في ذلك انه اما ال molecular form تبعهلكن + +33 +00:02:56,310 --> 00:03:01,290 +غالبا بيكون صغير لكن لو غيرنا في الموليكال الفورم + +34 +00:03:01,290 --> 00:03:07,190 +التلرجن هذا ممكن يصبح antigen او immunogen ال + +35 +00:03:07,190 --> 00:03:13,150 +allergen هو أي نوع ده تستطيع ان تحفظ اللي هو تسبب + +36 +00:03:13,150 --> 00:03:19,190 +حساسية allergic reaction و طبعا ال allergen ممكن + +37 +00:03:19,190 --> 00:03:21,830 +يخش الجسم عن طريق injection inhalation injection + +38 +00:03:21,830 --> 00:03:28,320 +or even contact with skinانواع الانتيجن يقال فيه + +39 +00:03:28,320 --> 00:03:32,300 +نوعين اكسوجينوس انتيجن هو عبارة عن انتيجن جاي من + +40 +00:03:32,300 --> 00:03:35,700 +برا اما by injection او inhalation او injection + +41 +00:03:35,700 --> 00:03:41,920 +دخل الجسم تلقفته انتيجن presenting cell زي + +42 +00:03:41,920 --> 00:03:46,000 +البيلينفوسايت على سبيل المثال عملتله endocytosis + +43 +00:03:46,000 --> 00:03:50,560 +او any other phagocytic cell عملت phagocytosis + +44 +00:03:50,560 --> 00:03:54,360 +طبعا بعد هي كذلك الانتيجن presenting cell بتعمل + +45 +00:03:54,360 --> 00:03:59,980 +عملياتprocessing للانتجن هذا وبتقطعه إلى fragments + +46 +00:03:59,980 --> 00:04:10,020 +الاندوجينس هو عبارة عن أي مادة أي انتجن يعني اللي + +47 +00:04:10,020 --> 00:04:15,600 +some regeneration within the cell ويمكن يصير في + +48 +00:04:15,600 --> 00:04:20,540 +due to normal as a result of normal metabolism أو + +49 +00:04:20,540 --> 00:04:29,150 +دخل فيروسأو بكتيريا الانفكشن الانتجين من اسم auto + +50 +00:04:29,150 --> 00:04:35,890 +-anti-antigen خاص ب our own antigen يعني و طبعا + +51 +00:04:35,890 --> 00:04:41,150 +this is a normal protein or a complex of protein + +52 +00:04:41,150 --> 00:04:47,830 +يعني ممكن يكون ال DNA ورا رنين لكن recognized by + +53 +00:04:47,830 --> 00:04:54,890 +immune system of the patientللمريض اللي عنده + +54 +00:04:54,890 --> 00:04:59,650 +autoimmune disease طبعا في هذا الحالة بنستثني اللي + +55 +00:04:59,650 --> 00:05:06,210 +هو ال sperm this antigen should under normal + +56 +00:05:06,210 --> 00:05:08,750 +condition not be the target of the immune system + +57 +00:05:08,750 --> 00:05:12,610 +في أي وضع طبيعي مش لازم ال self-antigen يكون + +58 +00:05:12,610 --> 00:05:18,370 +target لimmune response ماشي but due to the mainly + +59 +00:05:18,370 --> 00:05:25,350 +genetic and environmental factorالتبرنس يصبح له + +60 +00:05:25,350 --> 00:05:30,810 +break down ويبدأ الجسم يكوّن antibody for his own + +61 +00:05:30,810 --> 00:05:37,190 +antigen tumor antigen هي عبارة عن انتجين قاعدة على + +62 +00:05:37,190 --> 00:05:43,720 +سطح tumor cell مرتبطة بامل C class I موليكيولوهذه + +63 +00:05:43,720 --> 00:05:49,060 +الانتيجن مرات فقط موجودة على ال tumor cell وليس + +64 +00:05:49,060 --> 00:05:51,980 +على ال normal cell وفي هذه الحالة بيسموها tumor + +65 +00:05:51,980 --> 00:05:57,900 +specific antigen وطبعا ناتجة عن tumor specific + +66 +00:05:57,900 --> 00:05:58,660 +mutation + +67 +00:06:03,120 --> 00:06:12,300 +Immunogenicity هو قدرة + +68 +00:06:12,300 --> 00:06:17,680 +المادة وقدرة الانتيجين على تحفيز جهاز المناهس أو + +69 +00:06:17,680 --> 00:06:20,340 +تكوين انتيبادي أو cell-mediated immunity + +70 +00:06:20,340 --> 00:06:25,000 +.Antigenicity هو قدرة القدرة على الارتباط + +71 +00:06:25,000 --> 00:06:29,690 +بالانتيباديأو التفاعل مع الـ cell-mediated + +72 +00:06:29,690 --> 00:06:33,130 +immunity + +73 +00:06:33,130 --> 00:06:36,950 +و طبعاً قالوا في نوعين في complete antigen و في + +74 +00:06:36,950 --> 00:06:41,190 +incomplete antigen و مرات بيسموه الـ Heptin و ال + +75 +00:06:41,190 --> 00:06:45,070 +incomplete antigen له antigenic determinant لكنه + +76 +00:06:45,070 --> 00:06:51,030 +لا يستطيع أن يحفظ جهاز المناعموبالتالي هم مفقودين + +77 +00:06:51,030 --> 00:06:57,490 +واحد او اكتر من العلامات الأساسية العلامات المهمة + +78 +00:06:57,490 --> 00:07:07,050 +والتي نحتاجها لإدخال تجارب أمينية من أحسن الأمثلة + +79 +00:07:07,050 --> 00:07:11,770 +على ذلك هو الهابتين يعني الاسم المراد في ذلك هو + +80 +00:07:11,770 --> 00:07:16,990 +الهابتين وعادةً الهابتين لديه واحد إيبيتوب + +81 +00:07:19,070 --> 00:07:22,270 +Properties of Antigen كانوا الـ Foreigners طبيعي + +82 +00:07:22,270 --> 00:07:28,750 +جدا أنه لازم يكون فيه Foreigner Antigen لأن كل + +83 +00:07:28,750 --> 00:07:31,710 +الخلايا التي تعرفت على الـ Self-antigen خلصنا منها + +84 +00:07:31,710 --> 00:07:37,470 +أول بول أثناء تطور الانفوسايتز وبالتالي دلت + +85 +00:07:37,470 --> 00:07:40,330 +الخلايا التي تتعرف على ال Foreigner يبقى ال + +86 +00:07:40,330 --> 00:07:45,430 +Foreigner مطلوبة specificity لابد أن تتفاعل مع + +87 +00:07:45,430 --> 00:07:50,190 +specific antigenand high molecular weight طبعا ال + +88 +00:07:50,190 --> 00:07:55,490 +low molecular weight مقسموها إلى عدة أنواع ال low + +89 +00:07:55,490 --> 00:07:59,030 +molecular weight إما لا يستطيع إما induce + +90 +00:07:59,030 --> 00:08:04,310 +tolerance أو يعني + +91 +00:08:04,310 --> 00:08:10,270 +بيعتبر happeningوفي هذه الحالة لابد من ارتباطه + +92 +00:08:10,270 --> 00:08:16,270 +بمادة تانية عشان يكبر ويستحول إلى immunogen يبقى + +93 +00:08:16,270 --> 00:08:20,370 +ال molecular weight لازم يكبر عشان يكون هناك + +94 +00:08:20,370 --> 00:08:24,230 +induction لل response الاميونال مثال على هذا + +95 +00:08:24,230 --> 00:08:29,490 +الكلام اللي هو ال molecule of hemoglobin ال + +96 +00:08:29,490 --> 00:08:33,610 +Epitope or سابقا كانوا يسموها antigenic + +97 +00:08:33,610 --> 00:08:39,470 +determinant هو الجزء اللي برتبط بالبراتوبوالبراتوب + +98 +00:08:39,470 --> 00:08:44,410 +هو الجزء اللى في ال antibody اللى بيرتبط بال ابتوب + +99 +00:08:44,410 --> 00:08:53,370 +اللى على ال antigen ناشي ال ابتوب طبعا العدد ال + +100 +00:08:53,370 --> 00:08:58,930 +ابتوب على سطح ال antigen بيسمى التكافؤ وبيقولوا + +101 +00:08:58,930 --> 00:09:08,170 +انه كل ما كل one ابتوب بيزودأو كل ما زاد + +102 +00:09:08,170 --> 00:09:13,030 +الموليكيلار weight بقيمة عشر تلاف كل ما زاد الـ + +103 +00:09:13,030 --> 00:09:19,290 +Epitopes واحد يبوسين يعني كل عشر تلاف متوقع بالـ + +104 +00:09:19,290 --> 00:09:24,490 +one Epitope من صفات الـ Epitopes الموضوع الـ + +105 +00:09:24,490 --> 00:09:28,250 +Actual الموليكيلار shapes بيتعرف عليها الـ + +106 +00:09:28,250 --> 00:09:35,210 +Antibody Protein Epitope بيتكوّن منتلاتة لستة + +107 +00:09:35,210 --> 00:09:40,470 +أمينو أسس و ال large immunogen ممكن يحتوي على many + +108 +00:09:40,470 --> 00:09:44,130 +Epitopes و طبعا كل واحد منهم can trigger the + +109 +00:09:44,130 --> 00:09:48,890 +immune response و ال Epitopes ممكن يكونوا repeated + +110 +00:09:48,890 --> 00:09:53,830 +or repeating sequences يعني identical Epitopes و + +111 +00:09:53,830 --> 00:10:00,730 +ممكن يكونوا different Epitopes و بالتالي على + +112 +00:10:00,730 --> 00:10:05,100 +one antigen فقطالـ Antigenic Epitopes بيكونوا تلت + +113 +00:10:05,100 --> 00:10:14,680 +أنواع إما Confirmational وإما Linear وإما الـ + +114 +00:10:14,680 --> 00:10:17,640 +Antigenic Epitope هم تلت أنواع Confirmational + +115 +00:10:17,640 --> 00:10:23,160 +وLinear وNeo Antigenic وخلّيني أتفرّخ لكل منهم زي + +116 +00:10:23,160 --> 00:10:26,160 +ما تشوفين هي ال Confirmational هو عبارة عن + +117 +00:10:26,160 --> 00:10:33,370 +Discontinuous Molecular Shapeفي أكتر من الـ + +118 +00:10:33,370 --> 00:10:38,590 +Epitopes ده هي و upon denaturation بيفك ال antigen + +119 +00:10:38,590 --> 00:10:42,350 +و بنعتمد في هذه الحالة على ال primary structure + +120 +00:10:42,350 --> 00:10:44,730 +وبالتالي بيصير فيها أكتر من Epitopes اللي كلهم + +121 +00:10:44,730 --> 00:10:49,690 +بيتفاعلوا أو بيتكون ال antibody لهم ال neo antigen + +122 +00:10:49,690 --> 00:10:53,850 +ال linear antigen هو برهن continuous ده هو طبعا هي + +123 +00:10:53,850 --> 00:10:57,050 +واحد مخبأ و واحد موجود ممسوك بال antibody upon + +124 +00:10:57,050 --> 00:11:02,190 +denaturation بيفكوالانتيباد يتفاعل مع المخبأ ومع + +125 +00:11:02,190 --> 00:11:08,590 +مين ومع اللي كان مسجد معاه ال neo antigen هذا هو + +126 +00:11:08,590 --> 00:11:17,210 +برهر ال antigen مافيش فيه antigen برهر + +127 +00:11:17,210 --> 00:11:23,050 +تانية ومرجع نقول neo antigen determinantsهو برنامج + +128 +00:11:23,050 --> 00:11:28,050 +الـ Antidote استحدث يوم ما حصل في البروتيولايزيز + +129 +00:11:28,050 --> 00:11:36,090 +لأي كيميكال substance لأي مادة في الجسم مشق هذا + +130 +00:11:36,090 --> 00:11:42,350 +الـ Epitope وبالتالي الجسم يتعرف عليه كـ New + +131 +00:11:42,350 --> 00:11:49,450 +Epitopeهي الأنواع التلاتة لمين للـ Epitope هي تابع + +132 +00:11:49,450 --> 00:11:52,570 +واحد Linear وقولنا continuous و ال specificity + +133 +00:11:52,570 --> 00:11:55,630 +تعتمد على ال primary sequence ال size تبعه + +134 +00:11:55,630 --> 00:11:59,650 +typically من خمسة لستة sub units ال conformational + +135 +00:11:59,650 --> 00:12:04,090 +هي discontinuous غالبا involve multiple sub units + +136 +00:12:06,180 --> 00:12:11,640 +بيعتمد طبعا often located far apart in primary + +137 +00:12:11,640 --> 00:12:15,800 +sequence وموجود + +138 +00:12:15,800 --> 00:12:20,500 +in native in globular protein غالبا specificity + +139 +00:12:20,500 --> 00:12:22,760 +بتعتمد على ال confirmation change او three + +140 +00:12:22,760 --> 00:12:28,560 +dimensional shape وغالبا هو عبارة عن combination + +141 +00:12:28,560 --> 00:12:32,580 +of tertiary and quaternary structure وsupported + +142 +00:12:32,580 --> 00:12:36,690 +طبعا بمر بال primary وsecondary typeالقصة العامة + +143 +00:12:36,690 --> 00:12:44,650 +هي صعبة للحصول عليها ولكن + +144 +00:12:44,650 --> 00:12:50,750 +سيكوينسيا من حوالي 16 أمينواسيد + +145 +00:12:50,750 --> 00:12:55,290 +من بعض البروتين الانتيجين كانت موضوعة في مجموعة + +146 +00:12:55,290 --> 00:13:01,070 +البروتين الانتيجينانا انا انا انا انا انا انا انا + +147 +00:13:01,070 --> 00:13:02,150 +انا انا انا انا انا انا انا انا انا انا انا انا + +148 +00:13:02,150 --> 00:13:02,550 +انا انا انا انا انا انا انا انا انا انا انا انا + +149 +00:13:02,550 --> 00:13:02,970 +انا انا انا انا انا انا انا انا انا انا انا انا + +150 +00:13:02,970 --> 00:13:10,250 +انا انا انا انا انا انا انا انا انا انا انا انا + +151 +00:13:10,250 --> 00:13:11,290 +انا انا انا انا انا انا انا انا انا انا انا انا + +152 +00:13:11,290 --> 00:13:11,530 +انا انا انا انا انا انا انا انا انا انا انا انا + +153 +00:13:11,530 --> 00:13:25,510 +انا انا انا انا انا انا انا + +154 +00:13:25,510 --> 00:13:32,150 +اناالخاصية الانتيجينية كانت في نوعين ثيماس ديبندنت + +155 +00:13:32,150 --> 00:13:37,830 +وثيماس انديبندنت ثيماس ديبندنت يعني اللي تتمد على + +156 +00:13:37,830 --> 00:13:43,490 +تلينفوسايز presence هذا اللي بصير عبارة عن + +157 +00:13:43,490 --> 00:13:52,470 +تلينفوسايز قدّم الانتيجن تلينفوسايز في هذه الحالةو + +158 +00:13:52,470 --> 00:13:55,670 +الcells are activated لكن عشان ال cell في نشاط + +159 +00:13:55,670 --> 00:14:01,590 +التنتين ملزمنه two signal ال signal الأولانية هي + +160 +00:14:01,590 --> 00:14:08,870 +عبارة عن ارتباط ال receptor بال antigen و طبعا + +161 +00:14:08,870 --> 00:14:13,650 +بتاخد من عمله degradation و بطلع مرتبط بالامسي + +162 +00:14:13,650 --> 00:14:19,670 +مليكيون اللي في هذه الحالة ماكن عملش class twoهذا + +163 +00:14:19,670 --> 00:14:24,730 +هو الانتجرش المختلف درجة هذا طبعا هذا بيقدم لها ال + +164 +00:14:24,730 --> 00:14:31,770 +T cell فال TCR مرتبط بالانتجرش الممسوك بالامع + +165 +00:14:31,770 --> 00:14:35,730 +السينيه CD4 + +166 +00:14:35,730 --> 00:14:39,570 +مرتبط + +167 +00:14:39,570 --> 00:14:46,730 +بالامع السينيه CD4 مرتبط بالامع السينيه CD4 مرتبط + +168 +00:14:46,730 --> 00:14:52,880 +بالامع السينيهSecond Signal متمثلة بما يسمونه Co + +169 +00:14:52,880 --> 00:14:56,880 +-Stimulatory Reaction شو اللي بيصير؟ اللي بيصير + +170 +00:14:56,880 --> 00:15:00,280 +انه بيصير في ارتباط ما بين CD28 مش موجودة مع + +171 +00:15:00,280 --> 00:15:06,120 +الـCD86 على سطح الـGlyphosate و اللي في وجود + +172 +00:15:06,120 --> 00:15:11,040 +الـCD40 و40-Legend ده هم الارتباط اللي هدول يبتدوا + +173 +00:15:11,040 --> 00:15:17,250 +متمشيب الخليتينبتم تنشيط الخلية T، طبعا أول من + +174 +00:15:17,250 --> 00:15:21,970 +يتنشط هو الـ T العسل فبتفرد cytokine بتوعية نشتمين + +175 +00:15:21,970 --> 00:15:27,000 +لـ B-LymphocyteT الـ Cytokine بتفرج و هو برا + +176 +00:15:27,000 --> 00:15:33,340 +عيالته ماشي بتوعي نشطة الـ T الـ B lymphocyte طبعا + +177 +00:15:33,340 --> 00:15:37,560 +T lymphocyte لما تتنشط برضه بصير لها proliferation + +178 +00:15:37,560 --> 00:15:40,860 +and differentiation و D lymphocyte لما تتنشط بصير + +179 +00:15:40,860 --> 00:15:43,740 +لها proliferation and differentiation فهذا بتنقسم + +180 +00:15:43,740 --> 00:15:50,880 +الـ T cell الـ T البرز active cell عمي ورسل وهذا + +181 +00:15:50,880 --> 00:15:56,350 +بتتنشط برضه تنقسم لactive cell عمي ورسلوهذه + +182 +00:15:56,350 --> 00:16:02,530 +العملية بسموها thymus living تحتمد فيها عالمين على + +183 +00:16:02,530 --> 00:16:10,150 +ال T cell to activate the B cell ثم ثم ثم ثم ثم ثم + +184 +00:16:10,150 --> 00:16:17,070 +ثم + +185 +00:16:17,070 --> 00:16:21,390 +ثم ثم ثم + +186 +00:16:26,180 --> 00:16:31,860 +السيل يمكن ان يكون اكتفيت بشكل مباشر عندما يكون + +187 +00:16:31,860 --> 00:16:36,440 +هناك انتجن كبير بشكل هادر وهو مرتبط بهذا الشكل هو + +188 +00:16:36,440 --> 00:16:39,920 +يبنشط اللي هو سيل first signal وsecond signal + +189 +00:16:39,920 --> 00:16:45,140 +تنتهي المولودينماشي يعني هذا الارتباط بهذا الشكل + +190 +00:16:45,140 --> 00:16:51,540 +بيستعيد عن ال first and second signal و بتتبشط + +191 +00:16:51,540 --> 00:16:55,740 +بالإنفصار مباشرة لكن الفرق بين هذا و هذا هذا + +192 +00:16:55,740 --> 00:16:59,700 +النشاط و هذا النشاط ان هذا النشاط مافيش ميما ريسل + +193 +00:16:59,700 --> 00:17:05,240 +بتتكون لكن هذا النشاط ال T dependent بتتكون له + +194 +00:17:05,240 --> 00:17:05,960 +ميما ريسل + +195 +00:17:09,490 --> 00:17:13,570 +Super antigen هو برامج موليكيوم وبدأت على الـ + +196 +00:17:13,570 --> 00:17:18,090 +Potassium تينفوسايدميتاجين عندها القدرة ان تعمل + +197 +00:17:18,090 --> 00:17:21,130 +proliferation و differentiation لتينفوسايدميتاجين + +198 +00:17:21,130 --> 00:17:27,130 +وتشتغل من خلال ارتباطها بال MHC class II موليكيوم + +199 +00:17:27,130 --> 00:17:34,250 +غالبا هم برامجStaphylococcus Products هم مرتبطون + +200 +00:17:34,250 --> 00:17:40,790 +في تيروتوكسين وToxic Shock Syndrome للإنسان Super + +201 +00:17:40,790 --> 00:17:46,190 +Antigen هو عبارة عن إكسو توكسين غالباً لإكسيمة + +202 +00:17:46,190 --> 00:17:49,270 +high potent lymphocyte transforming يعني ميتو + +203 +00:17:49,270 --> 00:17:52,850 +جينيك activity لللمفوسايت في الوضع الطبيعي عشان + +204 +00:17:52,850 --> 00:17:58,450 +تعرفوا إيش يعني potent يعني highعلى اي activity في + +205 +00:17:58,450 --> 00:18:03,630 +الوضع الطبيعي الـ T cell response طبيعي تتنشط من + +206 +00:18:03,630 --> 00:18:07,410 +ال point واحد في الألف الى واحد في العاشر تلاف + +207 +00:18:07,410 --> 00:18:12,810 +تينفوسايتس تتنشط لكن يوم يكون لديك انتجنت عظيم + +208 +00:18:12,810 --> 00:18:16,630 +انتجنت 20% من الانفوسايتس اللي موجودة في الجسم + +209 +00:18:16,630 --> 00:18:18,410 +تتنشط مرة واحدة + +210 +00:18:39,320 --> 00:18:47,460 +هذا الانتجين بيكون داخل الانتجين و مرتبط + +211 +00:18:47,820 --> 00:18:51,140 +conventional يعني لكن في ال super antigen هي + +212 +00:18:51,140 --> 00:18:56,440 +الارتباط لل antigen من برا لبرا ال antigen وين + +213 +00:18:56,440 --> 00:19:01,280 +بيكون من برا لبرا super antigen طبعا الارتباط في + +214 +00:19:01,280 --> 00:19:04,160 +كل تلحتين بيصير في signal transduction بس في هذه + +215 +00:19:04,160 --> 00:19:08,600 +الحالة بيكون huge في ال super antigen و دي صورة + +216 +00:19:08,600 --> 00:19:15,020 +رسمية mitogen هي أي مادة عندها القدرة على أحداث + +217 +00:19:15,020 --> 00:19:20,440 +mitosisطبعا هنا بحكي على T cell activation و B + +218 +00:19:20,440 --> 00:19:26,280 +cell activation بدون الحاجة الى ال antigen + +219 +00:19:26,280 --> 00:19:31,160 +presenting cell امثل على ذلك الليكتين زي + +220 +00:19:31,160 --> 00:19:36,760 +الكوناكابالين A والليبوب و لسه كرايز واستفيلو كوكل + +221 +00:19:36,760 --> 00:19:42,900 +ال proteins الadjuvant هي عبارة عن طبعا كلمة + +222 +00:19:42,900 --> 00:19:50,780 +لاتينية بتعني to helpor to reach the goal تعريفا + +223 +00:19:50,780 --> 00:19:57,260 +هي any substance that helps and enhance the + +224 +00:19:57,260 --> 00:20:02,520 +pharmacological effect of a drug or increases the + +225 +00:20:02,520 --> 00:20:05,100 +ability of an antigen to stimulate the immune + +226 +00:20:05,100 --> 00:20:09,260 +response بيزود قدرة ال antigen على إيشعلى + +227 +00:20:09,260 --> 00:20:13,380 +stimulation of immune response قسم فيها أن قوائم + +228 +00:20:13,380 --> 00:20:19,380 +في النت لا تعد ولا تحصى بالنسبة لمين لل types of + +229 +00:20:19,380 --> 00:20:23,540 +adjuvant من أشهرها لفرنسا adjuvant منه complete + +230 +00:20:23,540 --> 00:20:29,560 +ومنه incomplete الهيبوظوم ال organic compound + +231 +00:20:29,560 --> 00:20:36,780 +cytokineand biodegradable nanoparticles شو بيعمل + +232 +00:20:36,780 --> 00:20:40,300 +الـ Adjuvant؟ قالوا فيله أكتر من قالية إنه واحد + +233 +00:20:40,300 --> 00:20:43,820 +prolonged persistence of immunogen molecule at the + +234 +00:20:43,820 --> 00:20:48,300 +site of injection بيطول، بيخلّي الانتجين يقعد فترة + +235 +00:20:48,300 --> 00:20:54,600 +أطول في site of injection Inhancement of co + +236 +00:20:54,600 --> 00:20:59,160 +-stimulatory signalالتي تسميناها second signal + +237 +00:20:59,160 --> 00:21:03,060 +ماشي بدون ال second signal ما بيحصل فيه activation + +238 +00:21:03,060 --> 00:21:08,140 +induction of granuloma بيستدعي خلايا كثيرة عشان في + +239 +00:21:08,140 --> 00:21:15,320 +منطقة الحدث وبالتالي بينشط ال immune response + +240 +00:21:15,320 --> 00:21:18,500 +stimulation of lymphocyte proliferation in a non + +241 +00:21:18,500 --> 00:21:22,220 +specific manner other antigen في ان ال + +242 +00:21:22,220 --> 00:21:26,950 +heterophilic antigen هو عبارة عنموجود في الهيومان + +243 +00:21:26,950 --> 00:21:31,390 +والانيمال والميكروبات مثل الـ Fosman Antigen النوع + +244 +00:21:31,390 --> 00:21:34,590 +التاني زينو انتيجن هو عبارة عن زينو جاية من أنيمل + +245 +00:21:34,590 --> 00:21:40,070 +جاية from different genus and generic different + +246 +00:21:40,070 --> 00:21:44,350 +generic مثل ال pathogenic انتيجن جاية من أنيمل + +247 +00:21:44,350 --> 00:21:48,350 +يعنى Allergenic Antigen هي عبارة عن specific + +248 +00:21:48,350 --> 00:21:52,410 +انتيجن موجودة in different individual وطبعا أشهر + +249 +00:21:52,410 --> 00:21:57,630 +هذه الانتيجن هي body group antigenAutoantigen هي + +250 +00:21:57,630 --> 00:22:01,990 +عبارة عن term pathological Autoantigenاتنا + +251 +00:22:01,990 --> 00:22:06,930 +الخاصة ماشي طبعا هذا الكلام بنطلق عليه بنطلقه أو + +252 +00:22:06,930 --> 00:22:10,650 +بنحكي فيه يوم يكون فيه autoimmune disease طبعا + +253 +00:22:10,650 --> 00:22:14,730 +نستثني من هذا الموضوع ل sperm antigen Idiotypic + +254 +00:22:14,730 --> 00:22:18,470 +antigen هو عبارة عن antibody لكن ال antibody كلنا + +255 +00:22:18,470 --> 00:22:24,550 +بنعرف فيه اختلافات في ال Fab region و يوم يدخل + +256 +00:22:25,320 --> 00:22:30,000 +الجسم بيتعامل معاه ك antigen وبالتالي بيكونله ايش؟ + +257 +00:22:30,000 --> 00:22:35,020 +antibody و طبعا هذه ال figure عبارة عن figure + +258 +00:22:35,020 --> 00:22:39,840 +بيحكي عن factors that influence immunogenicity of + +259 +00:22:39,840 --> 00:22:44,160 +a protein سواء كان ال size و ال dose و ال route و + +260 +00:22:44,160 --> 00:22:49,760 +هكذا و نتشكر لكم حسن الاستماع + diff --git a/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/QNU0sgyEFEM_raw.srt b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/QNU0sgyEFEM_raw.srt new file mode 100644 index 0000000000000000000000000000000000000000..70eb663f3ea376c87f4a17d5a35ce1edfac7a0f1 --- /dev/null +++ b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/QNU0sgyEFEM_raw.srt @@ -0,0 +1,1048 @@ +1 +00:00:01,650 --> 00:00:06,350 +بسم الله الرحمن الرحيم اليوم ان شاء الله هحكي في + +2 +00:00:06,350 --> 00:00:14,530 +المحاضرة رقم خمسة وهي بعنوان antigen من الصورة زى + +3 +00:00:14,530 --> 00:00:20,610 +ما انتوا شايفين ال antigen بياخد particular + +4 +00:00:20,610 --> 00:00:25,370 +structure اللى على سطحه ممكن يكون different + +5 +00:00:25,370 --> 00:00:28,310 +Epitopes شايفين Epitopes كل هذه عبارة عن Epitopes + +6 +00:00:28,310 --> 00:00:33,450 +اوما تسمى بالـ Antigenic Determinant اللي هي أماكن + +7 +00:00:33,450 --> 00:00:37,270 +ارتباط الـ Antibody فيها طيب نيجي نخش على المحاضرة + +8 +00:00:37,270 --> 00:00:42,950 +و نشوف ايش التعريفات بالمناسبة معظم هذه المحاضرة + +9 +00:00:42,950 --> 00:00:50,030 +هي عبارة عن تعريفات و مصطلحات منعية فال Antigen هي + +10 +00:00:50,030 --> 00:00:55,630 +عبارة عن أي مادة ت induce with the immune response + +11 +00:00:55,630 --> 00:01:00,900 +و بتتفاعل مع نواتج هذا ال immune responseوبالتالي + +12 +00:01:00,900 --> 00:01:04,640 +الانتيجن هي أصلها جاي من antibody generation + +13 +00:01:04,640 --> 00:01:08,680 +ماخدين أول أحرف من ال antibody generation طلعت + +14 +00:01:08,680 --> 00:01:16,400 +الكلمة antigen واليوم ثبت على أن الانتيجن لا يحفظ + +15 +00:01:16,400 --> 00:01:24,360 +تصنيع antibody فقط وإنما يحفظ تصنيع خلايا أخرى ضمن + +16 +00:01:24,360 --> 00:01:28,830 +اللي هو ال immune response اللي بطلعوبالتالي + +17 +00:01:28,830 --> 00:01:34,190 +Modern definition بيقول ان ال immune response هو + +18 +00:01:34,190 --> 00:01:37,070 +عبارة عن all substances that can be recognized by + +19 +00:01:37,070 --> 00:01:41,450 +adaptive immune response ال immunogen هو عبارة عن + +20 +00:01:41,450 --> 00:01:46,810 +أي مادة قادرة على تحفيز ال immune response بينما + +21 +00:01:46,810 --> 00:01:50,010 +ال antigen هو عبارة عن أي مادة قادرة على + +22 +00:01:58,460 --> 00:02:04,040 +الإميونوجين هو أي مادة قادرة على تحفيز جهاز + +23 +00:02:04,040 --> 00:02:07,740 +المناعة بينما الانتجين هي أي مادة قادرة على + +24 +00:02:07,740 --> 00:02:14,280 +التفاعل مع منتوج ال product of immune response + +25 +00:02:14,280 --> 00:02:20,680 +بينجوسين الانتيبادي أو الـsensitized cell لكن ليس + +26 +00:02:20,680 --> 00:02:25,080 +شرط ان يعمل immune response وبالتالي كل إميونوجين + +27 +00:02:25,080 --> 00:02:29,750 +هو عبارة عن انتجنليس كل انتجين هو عبارة عن + +28 +00:02:29,750 --> 00:02:34,630 +immunogen ال + +29 +00:02:34,630 --> 00:02:42,030 +tolerogen هو عبارة عن انتجين اللي لما بدخل الجسم + +30 +00:02:42,030 --> 00:02:47,770 +بيصير له استجابة منعية that invoke a specific + +31 +00:02:47,770 --> 00:02:51,310 +immune non responsiveness يعني عدم استجابة منعية + +32 +00:02:51,310 --> 00:02:56,310 +السبب في ذلك انه اما ال molecular form تبعهلكن + +33 +00:02:56,310 --> 00:03:01,290 +غالبا بيكون صغير لكن لو غيرنا في الموليكال الفورم + +34 +00:03:01,290 --> 00:03:07,190 +التلرجن هذا ممكن يصبح antigen او immunogen ال + +35 +00:03:07,190 --> 00:03:13,150 +allergen هو أي نوع ده تستطيع ان تحفظ اللي هو تسبب + +36 +00:03:13,150 --> 00:03:19,190 +حساسية allergic reaction و طبعا ال allergen ممكن + +37 +00:03:19,190 --> 00:03:21,830 +يخش الجسم عن طريق injection inhalation injection + +38 +00:03:21,830 --> 00:03:28,320 +or even contact with skinانواع الانتيجن يقال فيه + +39 +00:03:28,320 --> 00:03:32,300 +نوعين اكسوجينوس انتيجن هو عبارة عن انتيجن جاي من + +40 +00:03:32,300 --> 00:03:35,700 +برا اما by injection او inhalation او injection + +41 +00:03:35,700 --> 00:03:41,920 +دخل الجسم تلقفته انتيجن presenting cell زي + +42 +00:03:41,920 --> 00:03:46,000 +البيلينفوسايت على سبيل المثال عملتله endocytosis + +43 +00:03:46,000 --> 00:03:50,560 +او any other phagocytic cell عملت phagocytosis + +44 +00:03:50,560 --> 00:03:54,360 +طبعا بعد هي كذلك الانتيجن presenting cell بتعمل + +45 +00:03:54,360 --> 00:03:59,980 +عملياتprocessing للانتجن هذا وبتقطعه إلى fragments + +46 +00:03:59,980 --> 00:04:10,020 +الاندوجينس هو عبارة عن أي مادة أي انتجن يعني اللي + +47 +00:04:10,020 --> 00:04:15,600 +some regeneration within the cell ويمكن يصير في + +48 +00:04:15,600 --> 00:04:20,540 +due to normal as a result of normal metabolism أو + +49 +00:04:20,540 --> 00:04:29,150 +دخل فيروسأو بكتيريا الانفكشن الانتجين من اسم auto + +50 +00:04:29,150 --> 00:04:35,890 +-anti-antigen خاص ب our own antigen يعني و طبعا + +51 +00:04:35,890 --> 00:04:41,150 +this is a normal protein or a complex of protein + +52 +00:04:41,150 --> 00:04:47,830 +يعني ممكن يكون ال DNA ورا رنين لكن recognized by + +53 +00:04:47,830 --> 00:04:54,890 +immune system of the patientللمريض اللي عنده + +54 +00:04:54,890 --> 00:04:59,650 +autoimmune disease طبعا في هذا الحالة بنستثني اللي + +55 +00:04:59,650 --> 00:05:06,210 +هو ال sperm this antigen should under normal + +56 +00:05:06,210 --> 00:05:08,750 +condition not be the target of the immune system + +57 +00:05:08,750 --> 00:05:12,610 +في أي وضع طبيعي مش لازم ال self-antigen يكون + +58 +00:05:12,610 --> 00:05:18,370 +target لimmune response ماشي but due to the mainly + +59 +00:05:18,370 --> 00:05:25,350 +genetic and environmental factorالتبرنس يصبح له + +60 +00:05:25,350 --> 00:05:30,810 +break down ويبدأ الجسم يكوّن antibody for his own + +61 +00:05:30,810 --> 00:05:37,190 +antigen tumor antigen هي عبارة عن انتجين قاعدة على + +62 +00:05:37,190 --> 00:05:43,720 +سطح tumor cell مرتبطة بامل C class I موليكيولوهذه + +63 +00:05:43,720 --> 00:05:49,060 +الانتيجن مرات فقط موجودة على ال tumor cell وليس + +64 +00:05:49,060 --> 00:05:51,980 +على ال normal cell وفي هذه الحالة بيسموها tumor + +65 +00:05:51,980 --> 00:05:57,900 +specific antigen وطبعا ناتجة عن tumor specific + +66 +00:05:57,900 --> 00:05:58,660 +mutation + +67 +00:06:03,120 --> 00:06:12,300 +Immunogenicity هو قدرة + +68 +00:06:12,300 --> 00:06:17,680 +المادة وقدرة الانتيجين على تحفيز جهاز المناهس أو + +69 +00:06:17,680 --> 00:06:20,340 +تكوين انتيبادي أو cell-mediated immunity + +70 +00:06:20,340 --> 00:06:25,000 +.Antigenicity هو قدرة القدرة على الارتباط + +71 +00:06:25,000 --> 00:06:29,690 +بالانتيباديأو التفاعل مع الـ cell-mediated + +72 +00:06:29,690 --> 00:06:33,130 +immunity + +73 +00:06:33,130 --> 00:06:36,950 +و طبعاً قالوا في نوعين في complete antigen و في + +74 +00:06:36,950 --> 00:06:41,190 +incomplete antigen و مرات بيسموه الـ Heptin و ال + +75 +00:06:41,190 --> 00:06:45,070 +incomplete antigen له antigenic determinant لكنه + +76 +00:06:45,070 --> 00:06:51,030 +لا يستطيع أن يحفظ جهاز المناعموبالتالي هم مفقودين + +77 +00:06:51,030 --> 00:06:57,490 +واحد او اكتر من العلامات الأساسية العلامات المهمة + +78 +00:06:57,490 --> 00:07:07,050 +والتي نحتاجها لإدخال تجارب أمينية من أحسن الأمثلة + +79 +00:07:07,050 --> 00:07:11,770 +على ذلك هو الهابتين يعني الاسم المراد في ذلك هو + +80 +00:07:11,770 --> 00:07:16,990 +الهابتين وعادةً الهابتين لديه واحد إيبيتوب + +81 +00:07:19,070 --> 00:07:22,270 +Properties of Antigen كانوا الـ Foreigners طبيعي + +82 +00:07:22,270 --> 00:07:28,750 +جدا أنه لازم يكون فيه Foreigner Antigen لأن كل + +83 +00:07:28,750 --> 00:07:31,710 +الخلايا التي تعرفت على الـ Self-antigen خلصنا منها + +84 +00:07:31,710 --> 00:07:37,470 +أول بول أثناء تطور الانفوسايتز وبالتالي دلت + +85 +00:07:37,470 --> 00:07:40,330 +الخلايا التي تتعرف على ال Foreigner يبقى ال + +86 +00:07:40,330 --> 00:07:45,430 +Foreigner مطلوبة specificity لابد أن تتفاعل مع + +87 +00:07:45,430 --> 00:07:50,190 +specific antigenand high molecular weight طبعا ال + +88 +00:07:50,190 --> 00:07:55,490 +low molecular weight مقسموها إلى عدة أنواع ال low + +89 +00:07:55,490 --> 00:07:59,030 +molecular weight إما لا يستطيع إما induce + +90 +00:07:59,030 --> 00:08:04,310 +tolerance أو يعني + +91 +00:08:04,310 --> 00:08:10,270 +بيعتبر happeningوفي هذه الحالة لابد من ارتباطه + +92 +00:08:10,270 --> 00:08:16,270 +بمادة تانية عشان يكبر ويستحول إلى immunogen يبقى + +93 +00:08:16,270 --> 00:08:20,370 +ال molecular weight لازم يكبر عشان يكون هناك + +94 +00:08:20,370 --> 00:08:24,230 +induction لل response الاميونال مثال على هذا + +95 +00:08:24,230 --> 00:08:29,490 +الكلام اللي هو ال molecule of hemoglobin ال + +96 +00:08:29,490 --> 00:08:33,610 +Epitope or سابقا كانوا يسموها antigenic + +97 +00:08:33,610 --> 00:08:39,470 +determinant هو الجزء اللي برتبط بالبراتوبوالبراتوب + +98 +00:08:39,470 --> 00:08:44,410 +هو الجزء اللى في ال antibody اللى بيرتبط بال ابتوب + +99 +00:08:44,410 --> 00:08:53,370 +اللى على ال antigen ناشي ال ابتوب طبعا العدد ال + +100 +00:08:53,370 --> 00:08:58,930 +ابتوب على سطح ال antigen بيسمى التكافؤ وبيقولوا + +101 +00:08:58,930 --> 00:09:08,170 +انه كل ما كل one ابتوب بيزودأو كل ما زاد + +102 +00:09:08,170 --> 00:09:13,030 +الموليكيلار weight بقيمة عشر تلاف كل ما زاد الـ + +103 +00:09:13,030 --> 00:09:19,290 +Epitopes واحد يبوسين يعني كل عشر تلاف متوقع بالـ + +104 +00:09:19,290 --> 00:09:24,490 +one Epitope من صفات الـ Epitopes الموضوع الـ + +105 +00:09:24,490 --> 00:09:28,250 +Actual الموليكيلار shapes بيتعرف عليها الـ + +106 +00:09:28,250 --> 00:09:35,210 +Antibody Protein Epitope بيتكوّن منتلاتة لستة + +107 +00:09:35,210 --> 00:09:40,470 +أمينو أسس و ال large immunogen ممكن يحتوي على many + +108 +00:09:40,470 --> 00:09:44,130 +Epitopes و طبعا كل واحد منهم can trigger the + +109 +00:09:44,130 --> 00:09:48,890 +immune response و ال Epitopes ممكن يكونوا repeated + +110 +00:09:48,890 --> 00:09:53,830 +or repeating sequences يعني identical Epitopes و + +111 +00:09:53,830 --> 00:10:00,730 +ممكن يكونوا different Epitopes و بالتالي على + +112 +00:10:00,730 --> 00:10:05,100 +one antigen فقطالـ Antigenic Epitopes بيكونوا تلت + +113 +00:10:05,100 --> 00:10:14,680 +أنواع إما Confirmational وإما Linear وإما الـ + +114 +00:10:14,680 --> 00:10:17,640 +Antigenic Epitope هم تلت أنواع Confirmational + +115 +00:10:17,640 --> 00:10:23,160 +وLinear وNeo Antigenic وخلّيني أتفرّخ لكل منهم زي + +116 +00:10:23,160 --> 00:10:26,160 +ما تشوفين هي ال Confirmational هو عبارة عن + +117 +00:10:26,160 --> 00:10:33,370 +Discontinuous Molecular Shapeفي أكتر من الـ + +118 +00:10:33,370 --> 00:10:38,590 +Epitopes ده هي و upon denaturation بيفك ال antigen + +119 +00:10:38,590 --> 00:10:42,350 +و بنعتمد في هذه الحالة على ال primary structure + +120 +00:10:42,350 --> 00:10:44,730 +وبالتالي بيصير فيها أكتر من Epitopes اللي كلهم + +121 +00:10:44,730 --> 00:10:49,690 +بيتفاعلوا أو بيتكون ال antibody لهم ال neo antigen + +122 +00:10:49,690 --> 00:10:53,850 +ال linear antigen هو برهن continuous ده هو طبعا هي + +123 +00:10:53,850 --> 00:10:57,050 +واحد مخبأ و واحد موجود ممسوك بال antibody upon + +124 +00:10:57,050 --> 00:11:02,190 +denaturation بيفكوالانتيباد يتفاعل مع المخبأ ومع + +125 +00:11:02,190 --> 00:11:08,590 +مين ومع اللي كان مسجد معاه ال neo antigen هذا هو + +126 +00:11:08,590 --> 00:11:17,210 +برهر ال antigen مافيش فيه antigen برهر + +127 +00:11:17,210 --> 00:11:23,050 +تانية ومرجع نقول neo antigen determinantsهو برنامج + +128 +00:11:23,050 --> 00:11:28,050 +الـ Antidote استحدث يوم ما حصل في البروتيولايزيز + +129 +00:11:28,050 --> 00:11:36,090 +لأي كيميكال substance لأي مادة في الجسم مشق هذا + +130 +00:11:36,090 --> 00:11:42,350 +الـ Epitope وبالتالي الجسم يتعرف عليه كـ New + +131 +00:11:42,350 --> 00:11:49,450 +Epitopeهي الأنواع التلاتة لمين للـ Epitope هي تابع + +132 +00:11:49,450 --> 00:11:52,570 +واحد Linear وقولنا continuous و ال specificity + +133 +00:11:52,570 --> 00:11:55,630 +تعتمد على ال primary sequence ال size تبعه + +134 +00:11:55,630 --> 00:11:59,650 +typically من خمسة لستة sub units ال conformational + +135 +00:11:59,650 --> 00:12:04,090 +هي discontinuous غالبا involve multiple sub units + +136 +00:12:06,180 --> 00:12:11,640 +بيعتمد طبعا often located far apart in primary + +137 +00:12:11,640 --> 00:12:15,800 +sequence وموجود + +138 +00:12:15,800 --> 00:12:20,500 +in native in globular protein غالبا specificity + +139 +00:12:20,500 --> 00:12:22,760 +بتعتمد على ال confirmation change او three + +140 +00:12:22,760 --> 00:12:28,560 +dimensional shape وغالبا هو عبارة عن combination + +141 +00:12:28,560 --> 00:12:32,580 +of tertiary and quaternary structure وsupported + +142 +00:12:32,580 --> 00:12:36,690 +طبعا بمر بال primary وsecondary typeالقصة العامة + +143 +00:12:36,690 --> 00:12:44,650 +هي صعبة للحصول عليها ولكن + +144 +00:12:44,650 --> 00:12:50,750 +سيكوينسيا من حوالي 16 أمينواسيد + +145 +00:12:50,750 --> 00:12:55,290 +من بعض البروتين الانتيجين كانت موضوعة في مجموعة + +146 +00:12:55,290 --> 00:13:01,070 +البروتين الانتيجينانا انا انا انا انا انا انا انا + +147 +00:13:01,070 --> 00:13:01,070 +انا انا انا انا انا انا انا انا انا انا انا انا + +148 +00:13:01,070 --> 00:13:02,150 +انا انا انا انا انا انا انا انا انا انا انا انا + +149 +00:13:02,150 --> 00:13:02,550 +انا انا انا انا انا انا انا انا انا انا انا انا + +150 +00:13:02,550 --> 00:13:02,970 +انا انا انا انا انا انا انا انا انا انا انا انا + +151 +00:13:02,970 --> 00:13:10,250 +انا انا انا انا انا انا انا انا انا انا انا انا + +152 +00:13:10,250 --> 00:13:11,290 +انا انا انا انا انا انا انا انا انا انا انا انا + +153 +00:13:11,290 --> 00:13:11,290 +انا انا انا انا انا انا انا انا انا انا انا انا + +154 +00:13:11,290 --> 00:13:11,530 +انا انا انا انا انا انا انا انا انا انا انا انا + +155 +00:13:11,530 --> 00:13:25,510 +انا انا انا انا انا انا انا + +156 +00:13:25,510 --> 00:13:32,150 +اناالخاصية الانتيجينية كانت في نوعين ثيماس ديبندنت + +157 +00:13:32,150 --> 00:13:37,830 +وثيماس انديبندنت ثيماس ديبندنت يعني اللي تتمد على + +158 +00:13:37,830 --> 00:13:43,490 +تلينفوسايز presence هذا اللي بصير عبارة عن + +159 +00:13:43,490 --> 00:13:52,470 +تلينفوسايز قدّم الانتيجن تلينفوسايز في هذه الحالةو + +160 +00:13:52,470 --> 00:13:55,670 +الcells are activated لكن عشان ال cell في نشاط + +161 +00:13:55,670 --> 00:14:01,590 +التنتين ملزمنه two signal ال signal الأولانية هي + +162 +00:14:01,590 --> 00:14:08,870 +عبارة عن ارتباط ال receptor بال antigen و طبعا + +163 +00:14:08,870 --> 00:14:13,650 +بتاخد من عمله degradation و بطلع مرتبط بالامسي + +164 +00:14:13,650 --> 00:14:19,670 +مليكيون اللي في هذه الحالة ماكن عملش class twoهذا + +165 +00:14:19,670 --> 00:14:24,730 +هو الانتجرش المختلف درجة هذا طبعا هذا بيقدم لها ال + +166 +00:14:24,730 --> 00:14:31,770 +T cell فال TCR مرتبط بالانتجرش الممسوك بالامع + +167 +00:14:31,770 --> 00:14:35,730 +السينيه CD4 + +168 +00:14:35,730 --> 00:14:39,570 +مرتبط + +169 +00:14:39,570 --> 00:14:46,730 +بالامع السينيه CD4 مرتبط بالامع السينيه CD4 مرتبط + +170 +00:14:46,730 --> 00:14:52,880 +بالامع السينيهSecond Signal متمثلة بما يسمونه Co + +171 +00:14:52,880 --> 00:14:56,880 +-Stimulatory Reaction شو اللي بيصير؟ اللي بيصير + +172 +00:14:56,880 --> 00:15:00,280 +انه بيصير في ارتباط ما بين CD28 مش موجودة مع + +173 +00:15:00,280 --> 00:15:06,120 +الـCD86 على سطح الـGlyphosate و اللي في وجود + +174 +00:15:06,120 --> 00:15:11,040 +الـCD40 و40-Legend ده هم الارتباط اللي هدول يبتدوا + +175 +00:15:11,040 --> 00:15:17,250 +متمشيب الخليتينبتم تنشيط الخلية T، طبعا أول من + +176 +00:15:17,250 --> 00:15:21,970 +يتنشط هو الـ T العسل فبتفرد cytokine بتوعية نشتمين + +177 +00:15:21,970 --> 00:15:27,000 +لـ B-LymphocyteT الـ Cytokine بتفرج و هو برا + +178 +00:15:27,000 --> 00:15:33,340 +عيالته ماشي بتوعي نشطة الـ T الـ B lymphocyte طبعا + +179 +00:15:33,340 --> 00:15:37,560 +T lymphocyte لما تتنشط برضه بصير لها proliferation + +180 +00:15:37,560 --> 00:15:40,860 +and differentiation و D lymphocyte لما تتنشط بصير + +181 +00:15:40,860 --> 00:15:43,740 +لها proliferation and differentiation فهذا بتنقسم + +182 +00:15:43,740 --> 00:15:50,880 +الـ T cell الـ T البرز active cell عمي ورسل وهذا + +183 +00:15:50,880 --> 00:15:56,350 +بتتنشط برضه تنقسم لactive cell عمي ورسلوهذه + +184 +00:15:56,350 --> 00:16:02,530 +العملية بسموها thymus living تحتمد فيها عالمين على + +185 +00:16:02,530 --> 00:16:10,150 +ال T cell to activate the B cell ثم ثم ثم ثم ثم ثم + +186 +00:16:10,150 --> 00:16:17,070 +ثم + +187 +00:16:17,070 --> 00:16:21,390 +ثم ثم ثم + +188 +00:16:26,180 --> 00:16:31,860 +السيل يمكن ان يكون اكتفيت بشكل مباشر عندما يكون + +189 +00:16:31,860 --> 00:16:36,440 +هناك انتجن كبير بشكل هادر وهو مرتبط بهذا الشكل هو + +190 +00:16:36,440 --> 00:16:39,920 +يبنشط اللي هو سيل first signal وsecond signal + +191 +00:16:39,920 --> 00:16:45,140 +تنتهي المولودينماشي يعني هذا الارتباط بهذا الشكل + +192 +00:16:45,140 --> 00:16:51,540 +بيستعيد عن ال first and second signal و بتتبشط + +193 +00:16:51,540 --> 00:16:55,740 +بالإنفصار مباشرة لكن الفرق بين هذا و هذا هذا + +194 +00:16:55,740 --> 00:16:59,700 +النشاط و هذا النشاط ان هذا النشاط مافيش ميما ريسل + +195 +00:16:59,700 --> 00:17:05,240 +بتتكون لكن هذا النشاط ال T dependent بتتكون له + +196 +00:17:05,240 --> 00:17:05,960 +ميما ريسل + +197 +00:17:09,490 --> 00:17:13,570 +Super antigen هو برامج موليكيوم وبدأت على الـ + +198 +00:17:13,570 --> 00:17:18,090 +Potassium تينفوسايدميتاجين عندها القدرة ان تعمل + +199 +00:17:18,090 --> 00:17:21,130 +proliferation و differentiation لتينفوسايدميتاجين + +200 +00:17:21,130 --> 00:17:27,130 +وتشتغل من خلال ارتباطها بال MHC class II موليكيوم + +201 +00:17:27,130 --> 00:17:34,250 +غالبا هم برامجStaphylococcus Products هم مرتبطون + +202 +00:17:34,250 --> 00:17:40,790 +في تيروتوكسين وToxic Shock Syndrome للإنسان Super + +203 +00:17:40,790 --> 00:17:46,190 +Antigen هو عبارة عن إكسو توكسين غالباً لإكسيمة + +204 +00:17:46,190 --> 00:17:49,270 +high potent lymphocyte transforming يعني ميتو + +205 +00:17:49,270 --> 00:17:52,850 +جينيك activity لللمفوسايت في الوضع الطبيعي عشان + +206 +00:17:52,850 --> 00:17:58,450 +تعرفوا إيش يعني potent يعني highعلى اي activity في + +207 +00:17:58,450 --> 00:18:03,630 +الوضع الطبيعي الـ T cell response طبيعي تتنشط من + +208 +00:18:03,630 --> 00:18:07,410 +ال point واحد في الألف الى واحد في العاشر تلاف + +209 +00:18:07,410 --> 00:18:12,810 +تينفوسايتس تتنشط لكن يوم يكون لديك انتجنت عظيم + +210 +00:18:12,810 --> 00:18:16,630 +انتجنت 20% من الانفوسايتس اللي موجودة في الجسم + +211 +00:18:16,630 --> 00:18:18,410 +تتنشط مرة واحدة + +212 +00:18:39,320 --> 00:18:47,460 +هذا الانتجين بيكون داخل الانتجين و مرتبط + +213 +00:18:47,820 --> 00:18:51,140 +conventional يعني لكن في ال super antigen هي + +214 +00:18:51,140 --> 00:18:56,440 +الارتباط لل antigen من برا لبرا ال antigen وين + +215 +00:18:56,440 --> 00:19:01,280 +بيكون من برا لبرا super antigen طبعا الارتباط في + +216 +00:19:01,280 --> 00:19:04,160 +كل تلحتين بيصير في signal transduction بس في هذه + +217 +00:19:04,160 --> 00:19:08,600 +الحالة بيكون huge في ال super antigen و دي صورة + +218 +00:19:08,600 --> 00:19:15,020 +رسمية mitogen هي أي مادة عندها القدرة على أحداث + +219 +00:19:15,020 --> 00:19:20,440 +mitosisطبعا هنا بحكي على T cell activation و B + +220 +00:19:20,440 --> 00:19:26,280 +cell activation بدون الحاجة الى ال antigen + +221 +00:19:26,280 --> 00:19:31,160 +presenting cell امثل على ذلك الليكتين زي + +222 +00:19:31,160 --> 00:19:36,760 +الكوناكابالين A والليبوب و لسه كرايز واستفيلو كوكل + +223 +00:19:36,760 --> 00:19:42,900 +ال proteins الadjuvant هي عبارة عن طبعا كلمة + +224 +00:19:42,900 --> 00:19:50,780 +لاتينية بتعني to helpor to reach the goal تعريفا + +225 +00:19:50,780 --> 00:19:57,260 +هي any substance that helps and enhance the + +226 +00:19:57,260 --> 00:20:02,520 +pharmacological effect of a drug or increases the + +227 +00:20:02,520 --> 00:20:05,100 +ability of an antigen to stimulate the immune + +228 +00:20:05,100 --> 00:20:09,260 +response بيزود قدرة ال antigen على إيشعلى + +229 +00:20:09,260 --> 00:20:13,380 +stimulation of immune response قسم فيها أن قوائم + +230 +00:20:13,380 --> 00:20:19,380 +في النت لا تعد ولا تحصى بالنسبة لمين لل types of + +231 +00:20:19,380 --> 00:20:23,540 +adjuvant من أشهرها لفرنسا adjuvant منه complete + +232 +00:20:23,540 --> 00:20:29,560 +ومنه incomplete الهيبوظوم ال organic compound + +233 +00:20:29,560 --> 00:20:36,780 +cytokineand biodegradable nanoparticles شو بيعمل + +234 +00:20:36,780 --> 00:20:40,300 +الـ Adjuvant؟ قالوا فيله أكتر من قالية إنه واحد + +235 +00:20:40,300 --> 00:20:43,820 +prolonged persistence of immunogen molecule at the + +236 +00:20:43,820 --> 00:20:48,300 +site of injection بيطول، بيخلّي الانتجين يقعد فترة + +237 +00:20:48,300 --> 00:20:54,600 +أطول في site of injection Inhancement of co + +238 +00:20:54,600 --> 00:20:59,160 +-stimulatory signalالتي تسميناها second signal + +239 +00:20:59,160 --> 00:21:03,060 +ماشي بدون ال second signal ما بيحصل فيه activation + +240 +00:21:03,060 --> 00:21:08,140 +induction of granuloma بيستدعي خلايا كثيرة عشان في + +241 +00:21:08,140 --> 00:21:15,320 +منطقة الحدث وبالتالي بينشط ال immune response + +242 +00:21:15,320 --> 00:21:18,500 +stimulation of lymphocyte proliferation in a non + +243 +00:21:18,500 --> 00:21:22,220 +specific manner other antigen في ان ال + +244 +00:21:22,220 --> 00:21:26,950 +heterophilic antigen هو عبارة عنموجود في الهيومان + +245 +00:21:26,950 --> 00:21:31,390 +والانيمال والميكروبات مثل الـ Fosman Antigen النوع + +246 +00:21:31,390 --> 00:21:34,590 +التاني زينو انتيجن هو عبارة عن زينو جاية من أنيمل + +247 +00:21:34,590 --> 00:21:40,070 +جاية from different genus and generic different + +248 +00:21:40,070 --> 00:21:44,350 +generic مثل ال pathogenic انتيجن جاية من أنيمل + +249 +00:21:44,350 --> 00:21:48,350 +يعنى Allergenic Antigen هي عبارة عن specific + +250 +00:21:48,350 --> 00:21:52,410 +انتيجن موجودة in different individual وطبعا أشهر + +251 +00:21:52,410 --> 00:21:57,630 +هذه الانتيجن هي body group antigenAutoantigen هي + +252 +00:21:57,630 --> 00:22:01,990 +عبارة عن term pathological Autoantigenاتنا + +253 +00:22:01,990 --> 00:22:06,930 +الخاصة ماشي طبعا هذا الكلام بنطلق عليه بنطلقه أو + +254 +00:22:06,930 --> 00:22:10,650 +بنحكي فيه يوم يكون فيه autoimmune disease طبعا + +255 +00:22:10,650 --> 00:22:14,730 +نستثني من هذا الموضوع ل sperm antigen Idiotypic + +256 +00:22:14,730 --> 00:22:18,470 +antigen هو عبارة عن antibody لكن ال antibody كلنا + +257 +00:22:18,470 --> 00:22:24,550 +بنعرف فيه اختلافات في ال Fab region و يوم يدخل + +258 +00:22:25,320 --> 00:22:30,000 +الجسم بيتعامل معاه ك antigen وبالتالي بيكونله ايش؟ + +259 +00:22:30,000 --> 00:22:35,020 +antibody و طبعا هذه ال figure عبارة عن figure + +260 +00:22:35,020 --> 00:22:39,840 +بيحكي عن factors that influence immunogenicity of + +261 +00:22:39,840 --> 00:22:44,160 +a protein سواء كان ال size و ال dose و ال route و + +262 +00:22:44,160 --> 00:22:49,760 +هكذا و نتشكر لكم حسن الاستماع + diff --git a/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/W1bBU-2gsS4_raw.srt b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/W1bBU-2gsS4_raw.srt new file mode 100644 index 0000000000000000000000000000000000000000..93f31905970ec2e9004c7916cbd2ec3c8f5980af --- /dev/null +++ b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/W1bBU-2gsS4_raw.srt @@ -0,0 +1,1716 @@ +1 +00:00:01,260 --> 00:00:05,500 +بسم الله الرحمن الرحيم و حضرتنا اليوم عن ال + +2 +00:00:05,500 --> 00:00:12,140 +immunological aspect of tumor و + +3 +00:00:12,140 --> 00:00:13,520 +by definition tumor + +4 +00:00:16,970 --> 00:00:21,650 +errupt as a result of mutation or damage to one + +5 +00:00:21,650 --> 00:00:26,370 +cell leading to abnormal proliferation يعني في + +6 +00:00:26,370 --> 00:00:34,190 +مهاجمة في attack for one cell by mutation يؤدي إلى + +7 +00:00:34,190 --> 00:00:41,910 +damage وبتقري حصلتها abnormal proliferationالو + +8 +00:00:41,910 --> 00:00:48,050 +محصلة حدوث mutation احتمال من تلاتة احتمالات + +9 +00:00:48,050 --> 00:00:55,290 +الاولانى ان ال mutation تحدث خلل حقيقي في الخلية + +10 +00:00:55,290 --> 00:01:01,910 +وبالتالي بتصير الخلية not viable and this will be + +11 +00:01:01,910 --> 00:01:05,530 +recognized by mechanisms of the cell itself + +12 +00:01:06,450 --> 00:01:11,870 +وبالتالي سيندوس ابوبتوسس يبقى الحالة الأولانية انه + +13 +00:01:11,870 --> 00:01:15,090 +ال mutation قوية جدا لدرجة انها استكشفت + +14 +00:01:15,090 --> 00:01:19,890 +بالميكانزمات الخلية وهذا بيؤدي الى ابوبتوسس this + +15 +00:01:19,890 --> 00:01:24,610 +is a normal mechanismانه التانى الاحتمال التانى + +16 +00:01:24,610 --> 00:01:32,350 +immunogenic انه ال mutation احدثت يعني + +17 +00:01:32,350 --> 00:01:36,170 +حصلت او عملت expression على سطح الخلية + +18 +00:01:45,290 --> 00:01:51,110 +بالتالي ايضا احدثنا ابوبتوشيز فى هذا الجسم + +19 +00:01:51,110 --> 00:01:58,050 +الاحتمال التالتانها غير مستحيلة بمعنى ان الميوتشين + +20 +00:01:58,050 --> 00:02:03,410 +اصبح اتجاهه بشكل مستحيل بمعنى انه مستحيل بشكل + +21 +00:02:03,410 --> 00:02:10,770 +مستحيل داخل الجلد و لا يمكن الاستجابة الاكتشافه او + +22 +00:02:10,770 --> 00:02:18,070 +يمكن الاكتشافه كجلد بشكل مستحيل بشكل + +23 +00:02:18,070 --> 00:02:20,390 +غير مستحيل بشكل غير طبيعي + +24 +00:02:25,420 --> 00:02:32,200 +أسباب التحول من الجين البروتو انكوجين الى انكوجين + +25 +00:02:32,200 --> 00:02:37,400 +او ما يسمى بالانكوجينيسي يعني انه اما بيتنتج او + +26 +00:02:37,400 --> 00:02:41,480 +بينتج نتيجة increase in growth factor or increase + +27 +00:02:41,480 --> 00:02:44,880 +in growth factor receptor or increase in signal + +28 +00:02:44,880 --> 00:02:50,260 +transduction or increase in transcription فبالتالي + +29 +00:02:50,260 --> 00:02:53,000 +في محطة من محطات اللي هو + +30 +00:02:55,920 --> 00:03:01,660 +transcription بيحدث خلل دور ال B53 كلنا بنعرف ان + +31 +00:03:01,660 --> 00:03:05,280 +هو عبارة عن tumor suppressor gene وبالتالي يوم + +32 +00:03:05,280 --> 00:03:10,660 +يكون موجود في الخلية ده هو على الشجة الشمال بيصير + +33 +00:03:10,660 --> 00:03:13,780 +في upregulation for certain transcriptional + +34 +00:03:13,780 --> 00:03:17,780 +factors زي ال B5821 اللي هو عبارة عن cycling + +35 +00:03:17,780 --> 00:03:23,260 +kinase inhibitorماذا بعمل اللي هدا بعمل inhibition + +36 +00:03:23,260 --> 00:03:30,420 +او arresting لل G1 لل cell cycle ال G1 non ال G1 + +37 +00:03:30,420 --> 00:03:35,520 +phase وبالتالي بدي فرصة ل other transcriptional + +38 +00:03:35,520 --> 00:03:42,500 +factor اللي هو ال gat 45 to repair the damage + +39 +00:03:43,480 --> 00:03:49,780 +ألا إذا كان فشلة الخلية in repairing the damage + +40 +00:03:49,780 --> 00:03:52,440 +another transcriptional factor اللي هو ال packs + +41 +00:03:52,440 --> 00:03:56,800 +can induce apoptosis to the cell يبقى في فرصة + +42 +00:03:56,800 --> 00:04:03,760 +بتنعطى للخليةاللي بتديها اللي هو وجود B53 لإنه + +43 +00:04:03,760 --> 00:04:08,140 +بتواجه في الخلية بتحاول تصلح الخلل تصلح الخلل كان + +44 +00:04:08,140 --> 00:04:12,960 +بها ماتصلحش بأكس ترانسكريبشنال فاكترول اندوس او + +45 +00:04:12,960 --> 00:04:20,220 +ابتوسس طبعا في غياب ال cell ال B53 any DNA damage + +46 +00:04:20,220 --> 00:04:24,520 +will result in mutant cell which can proliferate + +47 +00:04:24,520 --> 00:04:33,200 +easily and malignant tumor canbe seen اي + +48 +00:04:33,200 --> 00:04:39,260 +الانكوجينيسي اما بتنتج بروتو انكوجين تتحول + +49 +00:04:39,260 --> 00:04:45,780 +لانكوجين نتيجة ميوتيشن ميوتيشن تضرب الجين او تضرب + +50 +00:04:45,780 --> 00:04:48,800 +ال tumor suppressor الجين اذا ضربت الجين تتحول + +51 +00:04:48,800 --> 00:04:52,200 +لانكوجين وقولنا اسبابه اما increase in growth + +52 +00:04:52,200 --> 00:04:55,300 +factor او growth factor receptor او exaggerated + +53 +00:04:55,300 --> 00:05:01,450 +response to growth factorأو الـ mutation في الـ + +54 +00:05:01,450 --> 00:05:07,750 +B53 فبتحول لـ dysfunctional + +55 +00:05:07,750 --> 00:05:12,250 +tumor subresorgen اللي بيقدّي إلى نصف ability to + +56 +00:05:12,250 --> 00:05:17,970 +repair damaged cell or induce autosis ال + +57 +00:05:17,970 --> 00:05:21,990 +characteristics of cancer cell ليش مختلفة؟ قالوا + +58 +00:05:21,990 --> 00:05:24,430 +it can escape normal intercellular communication + +59 +00:05:26,510 --> 00:05:33,190 +بإمكانها أن تتحرك كثيرا + +60 +00:05:33,190 --> 00:05:36,550 +و تتحرك كثيرا و تتحرك كثيرا و تتحرك كثيرا و تتحرك + +61 +00:05:36,550 --> 00:05:36,690 +كثيرا و تتحرك كثيرا و تتحرك كثيرا و تتحرك كثيرا و + +62 +00:05:36,690 --> 00:05:36,690 +تتحرك كثيرا و تتحرك كثيرا و تتحرك كثيرا و تتحرك + +63 +00:05:36,690 --> 00:05:37,490 +كثيرا و تتحرك كثيرا و تتحرك كثيرا و تتحرك كثيرا و + +64 +00:05:37,490 --> 00:05:40,250 +تتحرك كثيرا و تتحرك كثيرا و تتحرك كثيرا و تتحرك + +65 +00:05:40,250 --> 00:05:40,690 +كثيرا و تتحرك كثيرا و تتحرك كثيرا و تتحرك كثيرا و + +66 +00:05:40,690 --> 00:05:54,730 +تتحرك كثيرا و تتحرك كثيرا و + +67 +00:05:54,730 --> 00:06:00,140 +تتخلّينا نبدأ نحكي على tumor immunology و نجاوب + +68 +00:06:00,140 --> 00:06:04,260 +على الأسئلة القاتية نمرة واحد why does immune + +69 +00:06:04,260 --> 00:06:10,960 +system target on + +70 +00:06:10,960 --> 00:06:14,740 +cancer cell؟ نمرة اتنين what is the anti tumor + +71 +00:06:14,740 --> 00:06:18,220 +response؟ نمرة تلاتة why is it ineffective؟ نمرة + +72 +00:06:18,220 --> 00:06:25,320 +اربعة how can we augment it؟هو دليل بالتجربة اثبت + +73 +00:06:25,320 --> 00:06:30,040 +على انه في immune response واضح من خلال هذه + +74 +00:06:30,040 --> 00:06:33,280 +التجربة انه لو جبنا irradiated tumors اللي حقمناها + +75 +00:06:33,280 --> 00:06:38,200 +في fireثم بعد ذلك عملنا injection ل viable cell of + +76 +00:06:38,200 --> 00:06:42,540 +the same tumor في نفس الفار حلج الفار انه بيعمل + +77 +00:06:42,540 --> 00:06:47,460 +injection لهذا ال tumor دليل على انه في جهاز مناع + +78 +00:06:47,460 --> 00:06:54,420 +اشتغل و خلصنا من هذه الخلايا السرطانية بينما لو + +79 +00:06:54,420 --> 00:06:58,640 +حققنا نفس الفار بخلايا + +80 +00:06:58,640 --> 00:07:04,480 +from different tumorالرسبونس لخلق خلق خلق خلق خلق + +81 +00:07:04,480 --> 00:07:12,460 +خلق خلق خلق خلق خلق خلق خلق خلق خلق خلق خلق خلق + +82 +00:07:12,460 --> 00:07:13,660 +خلق خلق خلق خلق خلق خلق خلق خلق خلق خلق خلق خلق + +83 +00:07:13,660 --> 00:07:18,080 +خلق خلق خلق خلق خلق خلق خلق خلق خلق خلق خلق خلق + +84 +00:07:18,080 --> 00:07:18,080 +خلق خلق خلق خلق خلق خلق خلق خلق خلق خلق خلق خلق + +85 +00:07:18,080 --> 00:07:18,080 +خلق خلق خلق خلق خلق خلق خلق خلق خلق خلق خلق خلق + +86 +00:07:18,080 --> 00:07:25,060 +خلق خلق خلق خلق خلق خلق خلق خ + +87 +00:07:25,890 --> 00:07:28,830 +كيف يتعرف؟ قالوا tumor antigen وفيها نوعين من ال + +88 +00:07:28,830 --> 00:07:32,170 +tumor antigen في tumor specific antigen موجود فقط + +89 +00:07:32,170 --> 00:07:37,730 +على ال tumor cell وفي tumor associated antigen + +90 +00:07:37,730 --> 00:07:41,970 +اللي موجودة على both tumor cell and some normal + +91 +00:07:41,970 --> 00:07:42,370 +cell + +92 +00:07:45,520 --> 00:07:49,180 +فيه specific antigen؟ اه وجدوا انه certain tumor + +93 +00:07:49,180 --> 00:07:55,920 +او tumor can induce certain specific antigen زي ال + +94 +00:07:55,920 --> 00:08:02,240 +mutated tumor cell protein ناتج عن ايش؟ عن ال gene + +95 +00:08:02,240 --> 00:08:08,160 +ال chimeric gene اللي تكون sorry it's not chimeric + +96 +00:08:08,160 --> 00:08:11,480 +هو انما ال abnormal gene اللي اتكون ثم tumor + +97 +00:08:11,480 --> 00:08:13,620 +specific mutated oncogen + +98 +00:08:15,940 --> 00:08:23,500 +أو تمر سابريس والجين نفس الجين ممكن نفحصه او over + +99 +00:08:23,500 --> 00:08:28,240 +expression of normal antigen و التالي يصير فيه + +100 +00:08:28,240 --> 00:08:32,840 +abnormal response او viral oncogen expression on + +101 +00:08:32,840 --> 00:08:39,900 +surface of the cellوهذه صورة بتبين كيف صار هذا هو + +102 +00:08:39,900 --> 00:08:43,540 +عبارة عن normal cell فيها normal proteins صار في + +103 +00:08:43,540 --> 00:08:46,600 +expression or abnormal antigen expression for self + +104 +00:08:46,600 --> 00:08:51,040 +antigen على بالأمسي molecule على سطح الخلية بعد + +105 +00:08:51,040 --> 00:08:56,410 +مرات بيصير في زيادة لل normal selfهو انتجين اللي + +106 +00:08:56,410 --> 00:09:00,950 +يمكن ان يكون عبارة عن موليكيول MHC على سطح الخضرية + +107 +00:09:00,950 --> 00:09:07,990 +طبعا هذا سيكون معروف ب T cell وبالتالي + +108 +00:09:07,990 --> 00:09:15,450 +فيه reactionالـ tumor associates انتجين في عدد + +109 +00:09:15,450 --> 00:09:18,750 +منهم زي ال human carcinogenic endotrophin هرمون + +110 +00:09:18,750 --> 00:09:23,830 +الالفا فيتو بروتين prostate specific انتجين ميوسين + +111 +00:09:23,830 --> 00:09:28,730 +كانسر 125 وطبعا هذا موجود على ال normal cell + +112 +00:09:28,730 --> 00:09:33,890 +اميثيلا cell كارسينوما ثم CAA carcino embryonic + +113 +00:09:33,890 --> 00:09:39,750 +انتجين طبعا these can be used as tumor marker يعني + +114 +00:09:39,750 --> 00:09:48,160 +وجودها بيعني انه في tumorهذا figure بيبين ان كيف + +115 +00:09:48,160 --> 00:09:52,840 +ال CEA كان عالي في وجود ال tumor و after surgical + +116 +00:09:52,840 --> 00:09:59,980 +removal نزل ل normal و بعد يعني مائة يوم تانية + +117 +00:09:59,980 --> 00:10:05,020 +يعني تلت شهور تانين رجع تاني يطلع هذا هو و طبعا + +118 +00:10:05,020 --> 00:10:08,640 +هنا في مدى ما زاد عن ال normal بيصير في clinical + +119 +00:10:08,640 --> 00:10:14,070 +manifestation to that tumorTumor Surveillance + +120 +00:10:14,070 --> 00:10:18,830 +الحماية ضد التيومر ياله فيها انها خلايا منعية تعمل + +121 +00:10:18,830 --> 00:10:23,290 +ضد التيومر طبعا أشهر هذه الميكانيزمات متمثلة ب + +122 +00:10:23,290 --> 00:10:30,010 +function of macrophage or dendritic cell من خلال + +123 +00:10:30,010 --> 00:10:33,770 +ال antigen presentation or even attacking directly + +124 +00:10:33,770 --> 00:10:40,030 +the tumor cellوCD8 Cell-mediated Cytotoxicity + +125 +00:10:40,030 --> 00:10:44,750 +وAntibody Dependent Cell-mediated Cytotoxicity + +126 +00:10:44,750 --> 00:10:50,610 +وNatural Killer Cell ونشوف هذه الميكانيزمات كيف + +127 +00:10:50,610 --> 00:10:56,290 +تعمل طبعا CD8 تي سايتوتوكسيك سيلز بمجرد ما يتقدم + +128 +00:10:56,290 --> 00:11:01,130 +لها tumor antigen مرتبط بال MHC Class I مليكيول it + +129 +00:11:01,130 --> 00:11:06,180 +will induce cytotoxic responseLanky cell كنا نعرف + +130 +00:11:06,180 --> 00:11:10,340 +أنها ليست لديها ريسبتر على سطحها تتعرف على tumor + +131 +00:11:10,340 --> 00:11:17,340 +antigen وانما it can يعني sense the titer of MHC + +132 +00:11:17,340 --> 00:11:20,700 +molecule وبالتالي من خلاله it can induce cytotoxic + +133 +00:11:20,700 --> 00:11:25,900 +response يوم ما يقل بيصير فيه إيش cytotoxic + +134 +00:11:25,900 --> 00:11:29,260 +response ال micro fish بتشتل بطريقتين طريقة الأولى + +135 +00:11:29,260 --> 00:11:33,230 +نيةانه فيه انصات حلكتين ارتبط بال carbohydrate + +136 +00:11:33,230 --> 00:11:38,290 +residue اللى موجودة على ال tumor cell او ان tumor + +137 +00:11:38,290 --> 00:11:40,970 +cell اللى هي high number of carbohydrate زى ما + +138 +00:11:40,970 --> 00:11:46,430 +قلنا this + +139 +00:11:46,430 --> 00:11:49,290 +is an antigenic + +140 +00:11:52,330 --> 00:11:56,810 +كان تعتبر كإنتاج وكان يدفع إجابة مضحكة، بمعناه + +141 +00:11:56,810 --> 00:12:01,310 +إجابة مضحكة يعني إما في أجوسيتوسيس أو مصادر مصادر + +142 +00:12:01,310 --> 00:12:01,350 +مضحكة + +143 +00:12:05,180 --> 00:12:09,060 +الميكانيزم الرابع هو الـ cytokine يعني يجدوا انه + +144 +00:12:09,060 --> 00:12:11,820 +في certain receptor على سطح ال tumor cell for + +145 +00:12:11,820 --> 00:12:16,540 +cytokine which can induce apoptosis تالي في اكتر + +146 +00:12:16,540 --> 00:12:21,460 +من ميكانيزم اللي من خلالهم نقدر نتصدق للخلية + +147 +00:12:21,460 --> 00:12:26,340 +السلطانية لإن ال tumor cell can both activate and + +148 +00:12:26,340 --> 00:12:29,740 +suppress immunity وزي ما انتوا شايفين هذا هو صار + +149 +00:12:29,740 --> 00:12:37,340 +فيههذا الانيشيا التيومر دخل على تشو ماشي صار فيه + +150 +00:12:37,340 --> 00:12:41,820 +invasion and destruction او normal tissue وزي ما + +151 +00:12:41,820 --> 00:12:45,420 +انتوا شايفين فيه heat shock بروتين وفيه اللي هو + +152 +00:12:45,420 --> 00:12:50,960 +tumor antigen تنين هدولة و fever تنين هدولة يعني + +153 +00:12:50,960 --> 00:12:57,400 +they areبسموهم danger أو بسموهم اللي هو signal لل + +154 +00:12:57,400 --> 00:13:01,560 +immune response فبصير فيه اللي هو تصدي لهذه + +155 +00:13:01,560 --> 00:13:05,420 +الخلايا السرطانية من خلال تكوين reactive oxygen + +156 +00:13:05,420 --> 00:13:09,040 +species وهو بالتالي بيصير فيه نكروسيز + +157 +00:13:11,930 --> 00:13:16,350 +طبعا الخلايا السلطانية يوم ما تتطور و تزيد تتصدر + +158 +00:13:16,350 --> 00:13:19,030 +لها خلايا تانية زي ال T cell و ال dendritic cell و + +159 +00:13:19,030 --> 00:13:23,670 +الankle cell ولكن الخلايا السلطانية بشطرتها إيش + +160 +00:13:23,670 --> 00:13:27,950 +بتعمل؟ جالو بتعمل إما immunosuppressive to release + +161 +00:13:27,950 --> 00:13:30,250 +immunosuppressive mechanism + +162 +00:13:32,940 --> 00:13:39,300 +by immunosuppressive cytokine او انها تنشط ال T + +163 +00:13:39,300 --> 00:13:44,180 +regulatory cell وفي كلتال حالتين ال + +164 +00:13:44,180 --> 00:13:46,440 +immunosuppressive cytokine بيعمل inhibition لل + +165 +00:13:46,440 --> 00:13:51,080 +immune response و regulatory T cells أيضا تعمل + +166 +00:13:51,080 --> 00:13:54,760 +inhibition للخلايا السلطانية فبالتالي نصل لمرحلة + +167 +00:13:54,760 --> 00:13:58,760 +انه في توازن ما بين ال activation و ال inhibition + +168 +00:13:58,760 --> 00:14:03,140 +فإذا كان ال activation أكتر من ال inhibitionTumor + +169 +00:14:03,140 --> 00:14:07,400 +will regret وإذا كان ال inhibition أكتر من ال + +170 +00:14:07,400 --> 00:14:09,960 +activation Inhibition هو في immune response يعني + +171 +00:14:09,960 --> 00:14:15,560 +بدوا يصير فيه نشاط لل tumor cell و تتكاثر وتزداد + +172 +00:14:15,560 --> 00:14:21,020 +على حساب الأشهر ال immune suppressive drug أو ال + +173 +00:14:21,020 --> 00:14:25,440 +inhibitory cytokine هي IL-10 and tumor growth + +174 +00:14:25,440 --> 00:14:28,660 +factor beta أو بيسموه transforming growth factor + +175 +00:14:28,660 --> 00:14:29,640 +beta + +176 +00:14:32,120 --> 00:14:36,780 +الـ Basic Immunosurveillance + +177 +00:14:36,780 --> 00:14:40,980 +الحماية ضد السرطان او الخلايا السرطانية كما + +178 +00:14:40,980 --> 00:14:46,080 +تشاهدون هذه في Myeloma او Melanoma Cell نوع من نوع + +179 +00:14:46,080 --> 00:14:51,120 +الخلايا السرطانية بمجرد ما تكون موجودة في Danger + +180 +00:14:51,120 --> 00:14:56,720 +سيجنال مثل Heat Shock Protein و Interferon Alpha + +181 +00:14:58,710 --> 00:15:01,650 +هذه اللي تتحسسهم الـ Immature Dendritic Cell + +182 +00:15:01,650 --> 00:15:07,230 +بتتلقفهم كانتجين وتعملهم processing و بتطلعهم + +183 +00:15:07,230 --> 00:15:11,370 +مرتبطين على سطحة بال MHC موليكيول و بتتحول من + +184 +00:15:11,370 --> 00:15:14,870 +Immature Dendritic Cell لActivated Mature + +185 +00:15:14,870 --> 00:15:15,770 +Dendritic Cell + +186 +00:15:18,910 --> 00:15:20,230 +بتقدر تقدر تقدر تقدر تقدر تقدر تقدر تقدر تقدر تقدر + +187 +00:15:20,230 --> 00:15:24,490 +تقدر تقدر تقدر تقدر تقدر تقدر تقدر تقدر تقدر تقدر + +188 +00:15:24,490 --> 00:15:24,510 +تقدر تقدر تقدر تقدر تقدر تقدر تقدر تقدر تقدر تقدر + +189 +00:15:24,510 --> 00:15:28,150 +تقدر تقدر تقدر تقدر تقدر تقدر تقدر تقدر تقدر تقدر + +190 +00:15:28,150 --> 00:15:28,490 +تقدر تقدر تقدر تقدر تقدر تقدر تقدر تقدر تقدر تقدر + +191 +00:15:28,490 --> 00:15:28,790 +تقدر تقدر تقدر تقدر تقدر تقدر تقدر تقدر تقدر تقدر + +192 +00:15:28,790 --> 00:15:30,650 +تقدر تقدر تقدر تقدر تقدر تقدر تقدر تقدر تقدر تقدر + +193 +00:15:30,650 --> 00:15:33,470 +تقدر تقدر تقدر تقدر تهذه الخلايا بتطلع طبعا هذا + +194 +00:15:33,470 --> 00:15:35,950 +الكلام بيصير وين في ال lymph node بتطلع من ال + +195 +00:15:35,950 --> 00:15:42,750 +lymph node و بتروح على ال melanoma أو مكان ال + +196 +00:15:42,750 --> 00:15:47,270 +cancer و هناك تتنشط هذه الخلايا و بتواجه من ال + +197 +00:15:47,270 --> 00:15:53,190 +cancer cell و بتالي في cytotoxic destruction لل + +198 +00:15:53,190 --> 00:15:57,910 +tumor ال mechanism + +199 +00:15:57,910 --> 00:16:02,540 +by animation كاملاهي ال tumor cell او tumor + +200 +00:16:02,540 --> 00:16:06,340 +derived antigen اخدته ال macro phase عملت له + +201 +00:16:06,340 --> 00:16:11,080 +processing وطلع مرتبط بالامة C molecule سواء كان + +202 +00:16:11,080 --> 00:16:18,900 +هي macro phase قدمته ل T-Hilbert cell ونشطتها + +203 +00:16:18,900 --> 00:16:24,360 +من خلال IL-1 secretion T-Hilbert cell can be + +204 +00:16:24,360 --> 00:16:31,160 +activated and secret IL-2هو طبعا في هذه الحالة + +205 +00:16:31,160 --> 00:16:37,660 +تتنشط البرسيل الى memory cell و effector cell ايضا + +206 +00:16:37,660 --> 00:16:42,240 +ال microphage or B cell as antipresenting cell على + +207 +00:16:42,240 --> 00:16:47,000 +سطح MHC + +208 +00:16:47,000 --> 00:16:54,700 +class I which can also be presented to T cytotoxic + +209 +00:16:54,700 --> 00:17:02,450 +lymphocyte if thisطبعا الانتجين يسمى كإكساجينوس + +210 +00:17:02,450 --> 00:17:05,390 +انتجين فبتتحول الخلية إلى effector cell و memory + +211 +00:17:05,390 --> 00:17:09,490 +cell و التالي ال effector cell هتعمل it will + +212 +00:17:09,490 --> 00:17:12,270 +release pair foreign and apoptic signal to the + +213 +00:17:12,270 --> 00:17:19,720 +target cellالـ Antigen could be Endogenous Antigen + +214 +00:17:19,720 --> 00:17:24,040 +يعني في داخل الخلية وفي هذا الحالة نفس ال tumor + +215 +00:17:24,040 --> 00:17:29,380 +cell can play as antigen presenting cell و T + +216 +00:17:29,380 --> 00:17:37,340 +cytotoxic cell can recognize it and activate it و + +217 +00:17:37,340 --> 00:17:43,310 +it will release cytotoxic signalطبعا الميكانيزم + +218 +00:17:43,310 --> 00:17:49,350 +بشكل عام بكله الانتجين دخل وطلع مرتبط بال MSC + +219 +00:17:49,350 --> 00:17:55,250 +Class 1 و2 طبعا و2 هتعرف عليه الـ T-Helper Cell + +220 +00:17:55,250 --> 00:18:03,890 +اللي هي نوع واحد will be activated IL-2 و + +221 +00:18:03,890 --> 00:18:07,610 +proliferate to T-Helper memory and effector cell + +222 +00:18:09,950 --> 00:18:16,770 +عندما يتم إقدامه لـ T-Cytotoxic يمكن أيضًا أن يتم + +223 +00:18:16,770 --> 00:18:22,010 +إقدامه لـMemory وEffector Cell وطبعًا سيطرح + +224 +00:18:22,010 --> 00:18:28,810 +أبوبتكسيجنال سيندوس أبوبتوكسيز طبعًا في الوقت نفسه + +225 +00:18:28,810 --> 00:18:37,660 +إذا كانت الانتجينIndigenous التي تتعرف علي تي + +226 +00:18:37,660 --> 00:18:42,140 +سايتو توكسيك تطبعا هيطلع مرتبط بال MSC class 1 و + +227 +00:18:42,140 --> 00:18:46,700 +تتعرف علي تي سايتو توكسيك برضه بتفرز سايتو توكسيك + +228 +00:18:46,700 --> 00:18:52,780 +تي البرتوك also can be formed وبالتالي + +229 +00:18:52,780 --> 00:18:57,360 +هتفرز النقايا ال four اللي هينشط ميليمفوس عيطر + +230 +00:18:57,360 --> 00:19:06,640 +ايزينوفيليكأو clone و طبعا هذا هيقدى الى اللى هو + +231 +00:19:06,640 --> 00:19:13,760 +تكوين اما antibody او ADCC و NCO + +232 +00:19:17,640 --> 00:19:20,520 +الميكانيزم تبع الـ Antibody Dependency المدينة + +233 +00:19:20,520 --> 00:19:23,260 +الساعة التخصيصة لكلنا بنعرف إن الفاجوسة تكسل + +234 +00:19:23,260 --> 00:19:27,940 +موجودة على سطحها Receptor لل Fc portion of IgG أو + +235 +00:19:27,940 --> 00:19:32,870 +Complement تلاتة بيهوبالتالي عندما يتم إعادة تجارب + +236 +00:19:32,870 --> 00:19:36,310 +التجارب من هذه المجموعة الانتيبادي أو المجموعة + +237 +00:19:36,310 --> 00:19:39,250 +المميزة من هذه المجموعة سيتم إعادة تجارب التجارب + +238 +00:19:39,250 --> 00:19:41,970 +من هذه المجموعة الانتيبادي أو المجموعة المميزة من + +239 +00:19:41,970 --> 00:19:46,290 +هذه المجموعة الانتيبادي + +240 +00:19:46,290 --> 00:19:47,270 +أو المجموعة المميزة من هذه المجموعة الانتيبادي أو + +241 +00:19:47,270 --> 00:19:48,970 +المجموعة المميزة من هذه المجموعة الانتيبادي أو + +242 +00:19:48,970 --> 00:19:49,130 +المجموعة المميزة من هذه المجموعة الانتيبادي أو + +243 +00:19:49,130 --> 00:19:51,450 +المجموعة المميزة من هذه المجموعة الانتيبادي أو + +244 +00:19:51,450 --> 00:19:53,830 +المجموعة المميزة من هذه المجموعة الانتيباديهو + +245 +00:19:53,830 --> 00:19:57,430 +بيصير في cell to cell contact ومتما ان مسكت ال + +246 +00:19:57,430 --> 00:20:00,610 +target cell ال macro phage او ال unk cell will + +247 +00:20:00,610 --> 00:20:07,310 +induce an apoptic signal هاي ال unk cell تتعرف على + +248 +00:20:07,310 --> 00:20:10,930 +ال target cell من خلال ال expression هو عامة ال C + +249 +00:20:10,930 --> 00:20:16,210 +موليكيول يوم يقل ال titer بتهاجم الخلقية + +250 +00:20:17,810 --> 00:20:22,550 +كيف تهرب الخلية + +251 +00:20:22,550 --> 00:20:27,770 +السرطانية من ال surveillance الانميوني + +252 +00:20:27,770 --> 00:20:29,990 +يعني ان اذا احنا بقى با conservation of surface + +253 +00:20:29,990 --> 00:20:34,910 +market expression بنتطلعش ولا انتجن على سطحها + +254 +00:20:35,750 --> 00:20:41,650 +وبالتالي ممكن تشرد من ايش؟ من ال immune response + +255 +00:20:41,650 --> 00:20:47,490 +نبرة اتنين it will express على سطح Fc receptor + +256 +00:20:47,490 --> 00:20:51,350 +يعني receptor لل Fc portion و ب antibody و يوم + +257 +00:20:51,350 --> 00:20:54,510 +اتكون ال antibody هيثبت بال Fc مش فى الفأب + +258 +00:20:54,510 --> 00:21:00,970 +وبالتالي this will prevent phagocytosis of the + +259 +00:21:00,970 --> 00:21:05,150 +target cellنعمل تلاتة secretion of carbohydrate + +260 +00:21:05,150 --> 00:21:09,210 +residue بتفرز كمية كبيرة من ال carbohydrate which + +261 +00:21:09,210 --> 00:21:13,910 +can be recognized by macrophage + +262 +00:21:16,570 --> 00:21:22,750 +وبالتالي بيصير فيه binding with the macrophage + +263 +00:21:22,750 --> 00:21:26,810 +receptor وبالتالي بيبطل في cell to cell contact + +264 +00:21:26,810 --> 00:21:30,450 +نمر أربعة termination of cytokine receptor + +265 +00:21:30,450 --> 00:21:34,670 +expression كلنا فيه cytokine receptor على سطح ال + +266 +00:21:34,670 --> 00:21:38,850 +tumor cell ولما ارتبط فيها ال cytokine it can + +267 +00:21:38,850 --> 00:21:42,950 +induce apoptosis كل اللي بتعمل انها بتعملاللي هو + +268 +00:21:42,950 --> 00:21:45,530 +termination للـ cytokine receptor على سطحها + +269 +00:21:45,530 --> 00:21:51,510 +وبالتالي يصير الـ apoptosis is impossible طبعا هذا + +270 +00:21:51,510 --> 00:21:52,210 +أحد ال + +271 +00:21:55,760 --> 00:21:59,240 +الميكانيزمات اللى بيبين ان كيف اللى هو tumor + +272 +00:21:59,240 --> 00:22:05,700 +antigen can be expressed على سطح اللى هو الخلية من + +273 +00:22:05,700 --> 00:22:10,800 +خلال دخوله إلى ال endoplasmic reticulum من خلال ال + +274 +00:22:10,800 --> 00:22:14,260 +tab وبالتالي + +275 +00:22:14,260 --> 00:22:19,460 +يرتبط أثناء تصنيع ال MSC molecule class one + +276 +00:22:19,460 --> 00:22:23,870 +molecule يرتبط فيهبطلع على الجولجيا براتس و ال + +277 +00:22:23,870 --> 00:22:30,710 +cell surface membrane مرتبط بالاماشي ملفيول طبعا + +278 +00:22:30,710 --> 00:22:37,310 +هذا بيقدي الى ان الخلية زى CDA تتعرف على ال + +279 +00:22:37,310 --> 00:22:43,030 +antigen هذا ك self antigen وبالتالي ما بتهاجموا + +280 +00:22:45,070 --> 00:22:50,770 +Tumor can also escape immunity من خلال selection + +281 +00:22:50,770 --> 00:22:59,250 +of resistant clone طبعا هذا بيحدث لأنه بيصير more + +282 +00:22:59,250 --> 00:23:04,990 +genetic instability لنفس الخلية وبالتالي في + +283 +00:23:04,990 --> 00:23:08,190 +mutation حديثة حصلت وبالتالي صارت more resistant + +284 +00:23:08,190 --> 00:23:12,310 +or virulent to the age to the chemotherapy or to + +285 +00:23:12,310 --> 00:23:20,720 +the therapyوبالتالي مهما اتوقع ب treatment ولا + +286 +00:23:20,720 --> 00:23:23,540 +بدون treatment هى صار فى selection to certain + +287 +00:23:23,540 --> 00:23:28,160 +clone هدا هى الزرجهان وهنا حتى بال treatment + +288 +00:23:28,160 --> 00:23:34,420 +اعطينا treatment قتلت ال tumor cell لكن الخلايا + +289 +00:23:34,420 --> 00:23:39,120 +اللى صار فى selection for certain immunorefractory + +290 +00:23:39,120 --> 00:23:45,050 +phenotypic cell وهدا هى صارت ash صار الهنموعلى + +291 +00:23:45,050 --> 00:23:51,510 +الخلية حتى في وجود ال immunotherapy طبعا + +292 +00:23:51,510 --> 00:23:55,810 +ال immuno editing of cancer cell بتمر في تلت مراحل + +293 +00:23:55,810 --> 00:23:58,210 +مرحلة أولانية elimination بيكون ال immune response + +294 +00:23:58,210 --> 00:24:02,570 +أكتر من ال cancer cell و أقوى وبالتالي بيصير في + +295 +00:24:02,570 --> 00:24:05,670 +elimination ال cancer مرحلة تانية بيصير في + +296 +00:24:05,670 --> 00:24:08,850 +equilibrium بين قوة ال immune response و ما بين + +297 +00:24:09,440 --> 00:24:15,700 +اللي هو ال evading او ال cancer او tumor cell + +298 +00:24:15,700 --> 00:24:22,880 +escape وبالتالي بيكون في equally variant بين + +299 +00:24:22,880 --> 00:24:26,080 +الاتنين المرحلة التالتة من خلال اللي هو selection + +300 +00:24:26,080 --> 00:24:30,020 +of resistant clone وبالتالي تبدأ الخلايا السلطانية + +301 +00:24:30,020 --> 00:24:34,640 +تهرب من جهاز المناها وبتصير more resistant to it + +302 +00:24:34,640 --> 00:24:42,140 +وبالتالي بتنموحتى في وجود الـimmune response وسيلة + +303 +00:24:42,140 --> 00:24:46,660 +أخرى من وسائل الـ avoidance of tumor surveillance + +304 +00:24:46,660 --> 00:24:51,200 +أن الخلية السلطانية إما بتفرز cytokine inhibitory + +305 +00:24:51,200 --> 00:24:57,660 +cytokine which can inhibit a host T cell ماشي أيوة + +306 +00:24:57,660 --> 00:25:02,500 +اللي هو transforming growth factor beta أو من خلال + +307 +00:25:02,500 --> 00:25:06,440 +تنشيط اللي هو regulatory T lymphocytes اللي بتعمل + +308 +00:25:06,440 --> 00:25:10,500 +inhibitionبتعمل انهيبش نذية ريجلاترية بتعمل انهيبش + +309 +00:25:10,500 --> 00:25:15,120 +لـ T cell ياما بتنشط بتفرست Transforming Growth + +310 +00:25:15,120 --> 00:25:19,100 +Factor Beta انهيبطه لساعته كارية ياما من خلال ال + +311 +00:25:19,100 --> 00:25:22,580 +Transforming Growth Factor Beta it can activate a + +312 +00:25:22,580 --> 00:25:26,060 +regulatory T cell which can also inhibit the host + +313 +00:25:26,060 --> 00:25:33,180 +T cellوسيلة أخرى من وسائل أيضًا تهرب التخلية + +314 +00:25:33,180 --> 00:25:36,680 +السرطانية من الـ Immunosurveillance وهو By + +315 +00:25:36,680 --> 00:25:40,920 +Induction Apoptosis for T-Lymphocytes هي بنفسها + +316 +00:25:40,920 --> 00:25:45,920 +بتنشط اللي هو الـ Apoptosis ميكانيزم لـ T-cell و + +317 +00:25:45,920 --> 00:25:49,120 +التالي بتقتل الـ T لـ Cell كيف بتتم العملية؟ قالوا + +318 +00:25:49,120 --> 00:25:56,180 +By Releasing Fasligend طبعًا كلنا بنعرف أنهمخلية + +319 +00:25:56,180 --> 00:26:00,480 +الـ T-Lymphosite على سطحها فاز ريسبتر ويوم يرتبط + +320 +00:26:00,480 --> 00:26:04,360 +الفاز بالفازليجنت بيصير فيه ابورتوزيز induction + +321 +00:26:04,360 --> 00:26:09,920 +لابورتوزيز فهي الخلية tumor cell secret phase + +322 +00:26:09,920 --> 00:26:15,900 +ligand هو ايجار طبق بالفاز طبعا الفاز ده هو زي ما + +323 +00:26:15,900 --> 00:26:21,660 +انتوا شايفين الخلية + +324 +00:26:21,660 --> 00:26:24,360 +السرطانية ايجار طبقها طبعا الperceptor صار فيه + +325 +00:26:24,360 --> 00:26:28,140 +cell to cell contactمما أحدث induction للفاس ليجند + +326 +00:26:28,140 --> 00:26:32,540 +اللي بتبط بالفاس و بيصير في induction لإيش لأبو + +327 +00:26:32,540 --> 00:26:37,060 +بتوسس فالخلية بتقتل نفسها أو الخلية بتقتل أختها + +328 +00:26:37,060 --> 00:26:41,460 +لإن هي الفاس ليجند صار على سطحها ممكن ترتبط في + +329 +00:26:41,460 --> 00:26:46,680 +خلية تي لينفوسايت تانية على سطحها فاس و يقتلوا بعد + +330 +00:26:46,680 --> 00:26:53,880 +هاي يوم كثابيس اكتفيتي و يصار فيه cell deathماشى + +331 +00:26:53,880 --> 00:26:58,140 +طبعا كيف يتم العملية ده هي ال micro phage نترا فيه + +332 +00:26:58,140 --> 00:27:00,900 +ال tentative cell بيصير فيه inflammatory response + +333 +00:27:00,900 --> 00:27:06,060 +واضح لدن بي .. ضد ال tumor cell فشو بتعمل ال tumor + +334 +00:27:06,060 --> 00:27:10,100 +cell تروحوا هي عاملة induction ل phaseligand ل ال + +335 +00:27:10,100 --> 00:27:17,580 +tele lymphocyte وبالتالي قتلها الميكانيزمات + +336 +00:27:17,580 --> 00:27:19,320 +اللى أيضا + +337 +00:27:27,440 --> 00:27:31,900 +الخلية السلطانية لم تتعرف علي أي نوع من الانتجين + +338 +00:27:31,900 --> 00:27:36,820 +وبالتالي تلوفوسية لا تتعرف عليها او اما الانتيباد + +339 +00:27:36,820 --> 00:27:41,720 +اللي بيمسك فيها كان الخلية السلطانية على طول اندو + +340 +00:27:41,720 --> 00:27:48,980 +سايتوسس وبالتالي بيصير فيه degradation للانتيباد + +341 +00:27:54,930 --> 00:28:00,250 +مهاجمة للخلية او ان هذه الخلية السلطانية بتفرز + +342 +00:28:00,250 --> 00:28:04,130 +transform growth factor beta اللي اما بتنشط + +343 +00:28:04,130 --> 00:28:06,950 +regulatory T lymphocytes بتعمل inhibition للساعة + +344 +00:28:06,950 --> 00:28:13,070 +التكسيكة دهية او انه نفس ال inhibitor في ساعته كان + +345 +00:28:13,070 --> 00:28:21,150 +inhibit the effector cellfailure of immune + +346 +00:28:21,150 --> 00:28:24,690 +response against tumor بعد مرات بيفشل الجهاز المنح + +347 +00:28:24,690 --> 00:28:32,090 +أنه يصل حتى لل tumor قالوا في أسباب أيضا تلعب دور + +348 +00:28:32,090 --> 00:28:35,490 +في هذا الموضوع زي site of tumor يعني وجود ال tumor + +349 +00:28:35,490 --> 00:28:38,830 +في أماكن لا يستطيع أن يصل إليها اللي هو الجهاز + +350 +00:28:38,830 --> 00:28:43,730 +المنح زي ال I و ال CNS أو antigenic modulation أنه + +351 +00:28:43,730 --> 00:28:47,750 +باستمرار ال antigen tumor cell can undergo several + +352 +00:28:47,750 --> 00:28:51,010 +antigenic changesفي كل مرة بتغير لونها وتغير + +353 +00:28:51,010 --> 00:28:54,810 +الانتيجنات اللي على سطحها و blocking factor ال + +354 +00:28:54,810 --> 00:28:59,190 +immune complexes وحتى ال .. اللي بيسموها + +355 +00:28:59,190 --> 00:29:03,250 +cytophilic antibodies شو بتعمل؟ بتعمل masking لل + +356 +00:29:03,250 --> 00:29:07,710 +tumor antigen وبالتالي مافي شرط بعد بين effector + +357 +00:29:07,710 --> 00:29:13,190 +cell و ال .. or even the antibody .. lytic + +358 +00:29:13,190 --> 00:29:17,890 +antibody and the tumor cellيعني صار في masking + +359 +00:29:17,890 --> 00:29:26,390 +للخلية السرطانية اتخبط ماشي من ال immune complexes + +360 +00:29:26,390 --> 00:29:30,890 +وبالتالي لاتستطيع ان تصل اليها الخلية المناعية + +361 +00:29:30,890 --> 00:29:36,340 +عشان تقتلهاAnti tumor immunotherapy ماهي الحاجات + +362 +00:29:36,340 --> 00:29:39,320 +اللي فكروا فيها قالوا انهم رواحة tumor cell + +363 +00:29:39,320 --> 00:29:45,280 +vaccine ويعملوا vaccine طبعا + +364 +00:29:45,280 --> 00:29:49,800 +وجدوا ان بعض الناس اللي عندهم tumor عندهم T cell + +365 +00:29:49,800 --> 00:29:54,360 +directed against this tumor cell وبالتالي حاولوا + +366 +00:29:54,360 --> 00:29:59,380 +ينشطوا هذه الخلايا ال T lymphocyte اللي بتشتغل ضد + +367 +00:29:59,380 --> 00:30:04,350 +ال tumorو كيف بنشتغله من خلال الـ Allogenic Tumor + +368 +00:30:04,350 --> 00:30:07,530 +Cell أو الـ Autologous Tumor Cell يمكن أن يكون + +369 +00:30:07,530 --> 00:30:15,510 +اكثر ايراديايتد وتنعطى للمريض اما free او mixed + +370 +00:30:15,510 --> 00:30:19,790 +with adjuvant وبالتالي بتزود ال immunogenicity of + +371 +00:30:19,790 --> 00:30:24,090 +the tumor cell وبالتالي بيصير فيه نشاط اكتر لجهاز + +372 +00:30:24,090 --> 00:30:28,150 +المناقعة نمره اتنين immunization of the tumor + +373 +00:30:28,150 --> 00:30:33,580 +specific peptideطبعا في appropriate tumor + +374 +00:30:33,580 --> 00:30:38,440 +associated antigen had been cloned وكان بيبتايز + +375 +00:30:38,440 --> 00:30:44,320 +synthesized لكن للأسف الشديد يعني هذا لم يلقى + +376 +00:30:44,320 --> 00:30:51,340 +نجاحا كثيرا لإنه زي ال vaccine لإنه it's not easy + +377 +00:30:51,340 --> 00:30:58,760 +to grow this antigenCytokine therapy طبعا كل + +378 +00:30:58,760 --> 00:31:02,280 +Cytokine therapy الهدف فيها انه يحصل فيه Antihuman + +379 +00:31:02,280 --> 00:31:04,740 +response by increasing the level of a particular + +380 +00:31:04,740 --> 00:31:09,400 +cytokine بيعته Cytokines زي IL-2, Interferon and + +381 +00:31:09,400 --> 00:31:16,300 +Gamma GMCSF IL-7, IL-12 المشكلة انه these cytokine + +382 +00:31:16,300 --> 00:31:20,980 +have short half-life and they cannot be injected + +383 +00:31:20,980 --> 00:31:27,200 +in high doses لأنه it's toxicو المشكلة التالتة ان + +384 +00:31:27,200 --> 00:31:30,520 +هما يفعلون عمل غير محدود ما بيفرقوا ما بين tumor + +385 +00:31:30,520 --> 00:31:38,060 +cell و normal cellmonoclonal antibody أيضا استخدم + +386 +00:31:38,060 --> 00:31:44,840 +بانه في عملية نقل immunotoxin او radioisotopes او + +387 +00:31:44,840 --> 00:31:50,940 +even chemotherapy drug من خلال رابط اللي هو these + +388 +00:31:50,940 --> 00:31:54,560 +agents في ديله ويبتدل يبتدل يمشي يمشي لغاية مثل + +389 +00:31:54,560 --> 00:32:00,460 +الخلية السلطانية وهناك بيصير فيه ash اللي هو قتل + +390 +00:32:00,460 --> 00:32:04,620 +الخلية السلطانيةاليوم طبعا عملوا .. حاولوا يعملوا + +391 +00:32:04,620 --> 00:32:08,260 +حاجة بيسموها monoclonal antibody لكنه by specific + +392 +00:32:08,260 --> 00:32:14,080 +كيش one fab specific لل T cell و الفاب التانية + +393 +00:32:14,080 --> 00:32:17,040 +specific لل tumor associated antigen وبالتالي + +394 +00:32:17,040 --> 00:32:20,980 +بيقربوا ال T lymphocytes من ال tumor antigen + +395 +00:32:20,980 --> 00:32:25,100 +وبالتالي بيصير في cell to cell contact and killing + +396 +00:32:26,660 --> 00:32:31,040 +الجين ثيرابي يبرع ان يجمع ال .. يبرع ان يجمع ال .. + +397 +00:32:31,040 --> 00:32:32,380 +يبرع ان يجمع ال .. يبرع ان يجمع ال .. يبرع ان يجمع + +398 +00:32:32,380 --> 00:32:33,060 +ال .. يبرع ان يجمع ال .. يبرع أن يجمع ال .. يبرع + +399 +00:32:33,060 --> 00:32:33,400 +أن يجمع ال .. يبرع أن يجمع ال .. يبرع أن يجمع ال + +400 +00:32:33,400 --> 00:32:35,060 +.. يبرع أن يجمع ال .. يبرع أن يجمع ال .. يبرع أن + +401 +00:32:35,060 --> 00:32:39,360 +يجمع ال .. يبرع + +402 +00:32:39,360 --> 00:32:45,780 +أن يجمع ال .. يبرع أن يجمع ال .. يبرع أن يجمع ال + +403 +00:32:45,780 --> 00:32:47,500 +.. يبرع أن يجمع ال .. يبرع أن يجمع ال .. يبرع أن + +404 +00:32:47,500 --> 00:32:53,280 +يجمع ال .. يبرع أن يجمع ال .. يبرع أن يجمع ال .. + +405 +00:32:53,280 --> 00:32:55,650 +يبرع أن يجمأو كوستيمولاترية موليكيول أو حتى + +406 +00:32:55,650 --> 00:33:02,690 +موليكيول MSC ادابتف ايميونو ثيرابي ننقل خلايا زي + +407 +00:33:02,690 --> 00:33:05,690 +tumor infiltrating lymphocyte او lymphocyte + +408 +00:33:05,690 --> 00:33:10,330 +activating killer cellماشي المشكلة انه صعب جدا انه + +409 +00:33:10,330 --> 00:33:19,510 +تنمي عدد كبير من هذه الخلايا او بتالي صعب + +410 +00:33:19,510 --> 00:33:22,670 +انك تتوفرها الحاجة التانية بيصير في loss of + +411 +00:33:22,670 --> 00:33:27,070 +antigenic specificity of T cell والحاجة التالتة + +412 +00:33:27,070 --> 00:33:30,970 +انه بيصير في تبديل في homing pattern following + +413 +00:33:30,970 --> 00:33:36,800 +reinfusion يعني يتبطل تعرف طريق السليم إلهاميونو + +414 +00:33:36,800 --> 00:33:42,140 +دياجنوجز قالوا استخدموا طبعا في tumor استخدموا ال + +415 +00:33:42,140 --> 00:33:47,700 +antibody directed against tumor antigen وهذه ممثلة + +416 +00:33:47,700 --> 00:33:51,880 +جيدا في ال immunohistochemical analysis او في + +417 +00:33:51,880 --> 00:33:56,740 +روزين سيكشن في ال immunopathology او pathology lab + +418 +00:33:56,740 --> 00:34:00,740 +بيستخدموا اللي هو ال monoclonal antibody against + +419 +00:34:00,740 --> 00:34:08,180 +tumor antigenنبقى اثنين اناليسيز of blood وبنشوف + +420 +00:34:08,180 --> 00:34:11,760 +ال tumor markers وقولنا هذي عبارة عن diagnostic + +421 +00:34:11,760 --> 00:34:16,380 +tool في اكتر من حالة مرضية ناجحة الحاجة التالتة ان + +422 +00:34:16,380 --> 00:34:19,600 +ال antibody also can be used for imaging technique + +423 +00:34:21,330 --> 00:34:26,210 +و دي طبعا في هذه الحالة بربطه اللي هو ال + +424 +00:34:26,210 --> 00:34:30,930 +monoclonal antibody by radiolabel substance اللي + +425 +00:34:30,930 --> 00:34:33,530 +بيبقى تمشي لغاية ما تصل ال tumor antigen او ال + +426 +00:34:33,530 --> 00:34:37,250 +tumor cell تمسك فيها وبالتالي ال imaging can be + +427 +00:34:37,250 --> 00:34:43,210 +easily recognize the tumor antigen بهيك بنكون + +428 +00:34:43,210 --> 00:34:48,050 +غطينا تقريبا محاضرة اللي هو ال immuno + +429 +00:34:51,430 --> 00:34:55,750 +نشكر لكم حسن الاستماع + diff --git a/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/W_p3egjnWxo_postprocess.srt b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/W_p3egjnWxo_postprocess.srt new file mode 100644 index 0000000000000000000000000000000000000000..ee9723df6c2943ba8db2b7adf76f6a7df7807d15 --- /dev/null +++ b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/W_p3egjnWxo_postprocess.srt @@ -0,0 +1,1396 @@ +1 +00:00:03,190 --> 00:00:07,790 +عندما اتفقنا المحاضرة التانية اللي هي تقريبا جزء + +2 +00:00:07,790 --> 00:00:10,970 +كبير منها مراجعة هيحكي على T lymphocyte + +3 +00:00:10,970 --> 00:00:18,130 +development T lymphocyte development طبعا بداية + +4 +00:00:18,130 --> 00:00:22,030 +خلينا نحكي على TCR هذا ال structure تبع هو برعنة + +5 +00:00:22,030 --> 00:00:28,050 +تيرو دايمر مليكيول بيتكوّم into polypeptide + +6 +00:00:28,050 --> 00:00:30,250 +chain هي Alpha و Beta + +7 +00:00:33,170 --> 00:00:41,530 +كل واحدة منهم تحتوي على two domain الفجر + +8 +00:00:41,530 --> 00:00:47,170 +هذه variable براني يعني واللي + +9 +00:00:47,170 --> 00:00:51,370 +قريب من ال cell membrane هو ال constant region + +10 +00:00:51,370 --> 00:00:56,630 +يعني عندنا هذا هو ال variable هو بران V Alpha V + +11 +00:00:56,630 --> 00:01:03,000 +Betaوالـ constant هو عبارة عن C α C بيتا يبقى فيه + +12 +00:01:03,000 --> 00:01:05,480 +variable وفيه constant region وفيه Trans membrane + +13 +00:01:05,480 --> 00:01:11,300 +area وفيه short cytoplasmic tail ماشي they are + +14 +00:01:11,300 --> 00:01:15,340 +connected with each other by disulfide bond ماشي + +15 +00:01:15,340 --> 00:01:19,560 +disulfide bond طبعا فيه هنا بعتبر هذه المنطقة + +16 +00:01:19,560 --> 00:01:23,260 +عبارة عن hinge region وهنا بنشوف variable و + +17 +00:01:23,260 --> 00:01:28,020 +constant region are similar in structureلأ طبعا + +18 +00:01:28,020 --> 00:01:34,360 +antibody للي كان موجود في ال antibody نفس الحكاية + +19 +00:01:34,360 --> 00:01:37,980 +ال variable هي مسئولة عن ال antigen recognition + +20 +00:01:37,980 --> 00:01:45,940 +بينما ال constant مالهاش أي وظيفة هنا غير الارتباط + +21 +00:01:45,940 --> 00:01:49,680 +بال coreceptor molecule على سطح دي الأمفوسايت + +22 +00:01:55,860 --> 00:02:00,600 +بالمقارنة مع الانتيبادي الانتيبادي يمكن أن يكون + +23 +00:02:00,600 --> 00:02:03,520 +وجده في اتجاراتين واحدة مخفضة وواحدة مخفضة على + +24 +00:02:03,520 --> 00:02:06,440 +بلازمة الممبريل لكن ال TCR هو دائما موجود على + +25 +00:02:06,440 --> 00:02:11,760 +مخفضة بلازمة الممبريل ليس مخفضا هذا مقارنة ما بين + +26 +00:02:11,760 --> 00:02:16,000 +الانتيبادي وما بين ال TCR كما تشاهدون الاتنين + +27 +00:02:16,000 --> 00:02:18,700 +عندهم اتجارة + +28 +00:02:20,250 --> 00:02:24,070 +اللي بتحتوي على variable و على constant domain + +29 +00:02:24,070 --> 00:02:28,810 +variable و constant domain و طبعا متفقين على ان ال + +30 +00:02:28,810 --> 00:02:34,730 +variable هي ال V region و ال constant ده هي ال C + +31 +00:02:34,730 --> 00:02:38,250 +region طبعا في ال immunoglobulin في أنها ال + +32 +00:02:38,250 --> 00:02:43,030 +variable و هدولها ال constant variable constant و + +33 +00:02:43,030 --> 00:02:47,870 +هكذا و طبعا both have hinge region هي ال hinge + +34 +00:02:47,870 --> 00:02:52,790 +region هان و هانالانتباد يجعل الموليكيو مستقل، + +35 +00:02:52,790 --> 00:02:57,190 +وكذلك في الـTCR، + +36 +00:02:57,190 --> 00:03:04,090 +الموليكيو مستقل، وكذلك في الـTCR، الموليكيو مستقل، + +37 +00:03:04,090 --> 00:03:08,870 +وكذلك في الـTCR، الموليكيو مستقل، وكذلك في الـTCR، + +38 +00:03:08,870 --> 00:03:12,530 +الموليكيو مستقل، وكذلك في الـTCR، الموليكيو مستقل، + +39 +00:03:12,530 --> 00:03:15,730 +وكذلك في الـTCR، الموليكيو مستقل، وكذلك في الـTCR، + +40 +00:03:15,730 --> 00:03:16,130 +الموليكيو مستقل، وكذلك في الـTCR، الموليكيو مستقل، + +41 +00:03:16,130 --> 00:03:19,070 +وكذلك في الـTCR، الموليكيو مستقل، وكذلك في الـTCR، + +42 +00:03:19,070 --> 00:03:21,990 +الموليكيومقاله هنا Any of vector function وبالتالي + +43 +00:03:21,990 --> 00:03:27,770 +ما بخش في ال signal signal transduction طيب ال .. + +44 +00:03:27,770 --> 00:03:32,790 +برضه قررنا تنبع ال antibody و ال TCR و نشوف في ال + +45 +00:03:32,790 --> 00:03:36,330 +antigen recognition هذا عبارة عن antibody و هذا + +46 +00:03:36,330 --> 00:03:41,510 +عبارة عن TCR antibody موجود هو عبارة عن PCR ده هو + +47 +00:03:41,510 --> 00:03:46,450 +antibody is anchored on the cell membraneهو مرتبط + +48 +00:03:46,450 --> 00:03:49,930 +فيه بجانبه + +49 +00:03:49,930 --> 00:03:53,250 +نهر موليكيول بيسموه Menoglobulin Alpha + +50 +00:03:53,250 --> 00:03:55,410 +وMenoglobulin Beta هو المسؤول عن Signal + +51 +00:03:55,410 --> 00:04:04,990 +Transduction بينما في ال TCRعشان يتم التعرف على + +52 +00:04:04,990 --> 00:04:09,610 +الانتجن، يجب أن يكون الانتجن مقدم للـ TCR أو الـ T + +53 +00:04:09,610 --> 00:04:12,830 +-cell من خلال الـ Antigen Presenting Cell الهدهية + +54 +00:04:12,830 --> 00:04:17,670 +على سطح MLC مليكيوري مرتبط بالانتجن، والـ TCR + +55 +00:04:17,670 --> 00:04:20,530 +مرتبط بالانتجن، إذا كان هناك اي signal + +56 +00:04:20,530 --> 00:04:23,830 +transduction، فهناك فكتر فانكشن لا يوجد في + +57 +00:04:23,830 --> 00:04:24,050 +الانتجن، + +58 +00:04:30,080 --> 00:04:35,780 +مهم كوربولانت ليه؟ موليكيول هو CD3Z ماشي بجانب ال + +59 +00:04:35,780 --> 00:04:40,740 +TCR هم اللي يلهم الـ cytoplasmic tail ده هو و هم + +60 +00:04:40,740 --> 00:04:45,220 +اللي بيقولوا بالـ signal transduction الحاجة + +61 +00:04:45,220 --> 00:04:50,100 +التانية ال .. ال .. ال antibody في ال constant + +62 +00:04:50,100 --> 00:04:53,900 +region هو ال factor of function ماشي زي ال + +63 +00:04:53,900 --> 00:05:00,030 +complement fixationوهكذا بينما في ال PCR مايلو + +64 +00:05:00,030 --> 00:05:10,050 +ونشوف نشوف أول ايش أول فرق بين التانين تالت PCR + +65 +00:05:10,050 --> 00:05:14,550 +بيبتايد presented by أناسي مليكيول بينما ال PCR + +66 +00:05:14,550 --> 00:05:17,710 +recognize antigen without requirement of + +67 +00:05:17,710 --> 00:05:23,610 +presentation ال recognition is mediated by + +68 +00:05:23,610 --> 00:05:29,170 +variable domain في الجهتينماشى تلقى تلقى تلقى تلقى + +69 +00:05:29,170 --> 00:05:30,330 +تلقى تلقى تلقى تلقى تلقى تلقى تلقى تلقى تلقى تلقى + +70 +00:05:30,330 --> 00:05:30,970 +تلقى تلقى تلقى تلقى تلقى تلقى تلقى تلقى تلقى تلقى + +71 +00:05:30,970 --> 00:05:34,670 +تلقى تلقى تلقى تلقى تلقى تلقى تلقى تلقى تلقى تلقى + +72 +00:05:34,670 --> 00:05:36,370 +تلقى تلقى تلقى تلقى تلقى تلقى تلقى تلقى تلقى تلقى + +73 +00:05:36,370 --> 00:05:42,970 +تلقى تلقى تلقى تلقى تلقى تلقى تلقى تلقى تلقى تلقى + +74 +00:05:42,970 --> 00:05:47,790 +تلقى + +75 +00:05:47,790 --> 00:05:51,950 +ت + +76 +00:05:54,320 --> 00:05:57,820 +لأ انا عبارة عن TCR ايه Alpha One Alpha Two Alpha + +77 +00:05:57,820 --> 00:06:01,500 +Three وده عبارة عن Class One MSC Class One + +78 +00:06:01,500 --> 00:06:06,120 +Molecule ماشي ايه الانتجين يكبر بتاعتك تكتب Alpha + +79 +00:06:06,120 --> 00:06:13,360 +One Alpha Two دمية ال MSC Class One 100% وزي ما + +80 +00:06:13,360 --> 00:06:22,480 +انتوا شايفين TCR مايلو يمسك الا في الانتجن كنت + +81 +00:06:22,480 --> 00:06:27,000 +Alphaالـ Beta-Chain أو الـ TCR تتعامل مع بيبتايد + +82 +00:06:27,000 --> 00:06:31,560 +100% الـ Alpha والبيتا بتاعة الـ TCR تنتهي مرتبط + +83 +00:06:31,560 --> 00:06:39,520 +في الـ TCR الـ + +84 +00:06:39,520 --> 00:06:42,840 +Addition of residue يعني في أطراف خارجية من الـ + +85 +00:06:42,840 --> 00:06:47,600 +TCR هي اللي بترتبط بين الأمسي موليكيول زي ما + +86 +00:06:47,600 --> 00:06:53,210 +شايفين هي الـ TCR مسيك في الانتجنوهي الـ TCR مع + +87 +00:06:53,210 --> 00:06:58,710 +علامة الـ C-molecule طرفيا برضه بيلتقوا و بيمسكوا + +88 +00:06:58,710 --> 00:07:03,930 +الـ Antigen Resonating Cell هي اللي بتقدم الـ + +89 +00:07:03,930 --> 00:07:09,130 +Antigen للـ T Cell خلال ارتباط الـ Antigen بالـ + +90 +00:07:09,130 --> 00:07:12,170 +Measuring Stock Compatibility Complex Class I و + +91 +00:07:12,170 --> 00:07:16,360 +Class II شوفوا إيش اللي بصيرهي عبارة عن antigen + +92 +00:07:16,360 --> 00:07:21,520 +presenting z قدمت الانتجن لمين للتيسل ده هو للتيسل + +93 +00:07:21,520 --> 00:07:28,440 +في الجهتين بس واحدة مقدمة ل cd8 والتانية مقدمة + +94 +00:07:28,440 --> 00:07:34,460 +لمين ل cd4 واتفقنا على اما ال c class واحد هو من + +95 +00:07:34,460 --> 00:07:43,650 +يقدم اللي هوانتجن لـ CD8 تي سايتو توكسيك و بينما + +96 +00:07:43,650 --> 00:07:50,830 +ال Exogenous او MHC class 2 هو من يرتبط بالانتجن + +97 +00:07:50,830 --> 00:07:57,390 +الخارجي و بيقدمه لمين لتيه البرسيل اللي هي CD4 هي + +98 +00:07:57,390 --> 00:08:03,310 +CD8 طبعا في منه في هذه الحالة زي ما انتوا شايفين + +99 +00:08:03,310 --> 00:08:07,400 +ال CD8 بيرتبط في ال MHC مليكيول من براهذا هو بس + +100 +00:08:07,400 --> 00:08:09,880 +بيرتبط في ال constant region مش في ال variable ال + +101 +00:08:09,880 --> 00:08:14,640 +variable ماسك في مين؟ في ال antigen وهي ال CD4 نفس + +102 +00:08:14,640 --> 00:08:21,320 +الحكاية sorry تي antigen are linear molecule in + +103 +00:08:21,320 --> 00:08:29,460 +contrast to MHC both CD4 و CD8 do not interact + +104 +00:08:29,460 --> 00:08:38,360 +with the antigenic peptideشايفين هاي ال TCR وهي ال + +105 +00:08:38,360 --> 00:08:41,980 +MHC موليكول وهي ال Antigen في المصر راهزوا هنا + +106 +00:08:41,980 --> 00:08:48,540 +constant region شايفين اللي هو ال CD4 مسك في مين + +107 +00:08:48,540 --> 00:08:56,430 +ال constant region او مين of MHC موليكولCD4 وCD8 + +108 +00:08:56,430 --> 00:08:59,490 +تتعامل مع الـ invariant اللي هي constant residue + +109 +00:08:59,490 --> 00:09:05,850 +of MSC class 1 و2 والتالي ال specificity of + +110 +00:09:05,850 --> 00:09:11,010 +response اللي مسئول عنها مش ال antigen وانما اللي + +111 +00:09:11,010 --> 00:09:14,010 +مسئول عنها هو ال nature of antigen presenting cell + +112 +00:09:14,010 --> 00:09:22,550 +من يقنطم ال antigen كيف يصير يا سيد العزيز؟بنعمل + +113 +00:09:22,550 --> 00:09:33,270 +اختلاف خصيص بين الانتجن + +114 +00:09:33,270 --> 00:09:41,470 +وانتجن الانتجن وانتجن + +115 +00:09:41,470 --> 00:09:48,290 +الانتجن وانتجن + +116 +00:09:48,290 --> 00:09:49,030 +الانتجن وانتجن الانتجن وانتجن الانتجن وانتجن + +117 +00:09:49,030 --> 00:09:50,030 +الانتجن وانتجن الانتجن وانتجن الانتجن وانتجن + +118 +00:09:50,030 --> 00:09:50,090 +الانتجن وانتجن الانتجن وانتجن الانتجن وانتجن ال + +119 +00:09:51,050 --> 00:09:59,110 +واحدة بتعمل phagocytosis والتانية by endocytosis + +120 +00:09:59,110 --> 00:10:02,830 +وهم + +121 +00:10:02,830 --> 00:10:10,000 +بيخش ال antigen على داخل الخليةبنعمله processing و + +122 +00:10:10,000 --> 00:10:15,940 +بيطلع مرتبط على سطح الخلية بواسطة اللي هو ال MSC + +123 +00:10:15,940 --> 00:10:21,600 +molecule class two molecule both have class two + +124 +00:10:22,150 --> 00:10:26,050 +مهشي موليكيول اللي على سطح طبعا بتقدم الانتجين في + +125 +00:10:26,050 --> 00:10:29,810 +هذه الحالة اللتي هي البرسيل اللي هي CD4 فده هي + +126 +00:10:29,810 --> 00:10:35,690 +both ماشي RCD4 طبعا بعدين بيصير فيه cytokine + +127 +00:10:35,690 --> 00:10:41,880 +release متمرطبطالجهتين و ال telephosize بتساعد ال + +128 +00:10:41,880 --> 00:10:45,660 +macro phage تعمل نشط ال macro phage و أثناء + +129 +00:10:45,660 --> 00:10:52,540 +تنشيطها كمان بتعمل destruction ل ال phagocytosed + +130 +00:10:52,540 --> 00:10:57,800 +يعني بتنشط ال macro phage to phagocytosedلـ + +131 +00:10:57,800 --> 00:11:02,980 +Microbe and Kill it ونفس الحكاية تساعد نشط + +132 +00:11:02,980 --> 00:11:06,900 +البيلينفوسايت وبالتالي بتطلع ان Antibody هذا هو + +133 +00:11:06,900 --> 00:11:14,660 +which can fix the antigen and destroy it بينما ال + +134 +00:11:14,660 --> 00:11:19,380 +MSC Class I Molecule هذا هو موجود على كل خلايا جسم + +135 +00:11:19,380 --> 00:11:25,420 +الإنسان وهو طبعا بيتعامل مع Endogenous Antigen + +136 +00:11:26,520 --> 00:11:30,060 +هيتولد الـ Antigen في داخل الخلية فبيسلم + +137 +00:11:30,060 --> 00:11:33,920 +processing وبيطلع مرتبط بالـ MSC Class I مليكوري + +138 +00:11:33,920 --> 00:11:38,720 +اللي بيتقدم ل CD8-Cytoplytic أو Cytotoxic + +139 +00:11:38,720 --> 00:11:43,520 +تيليوفوسايت اللي بتعمل Direct Link للـ Target Cell + +140 +00:11:43,520 --> 00:11:51,640 +اللي فيها للمساواة بالـ Antigen الـ + +141 +00:11:51,640 --> 00:11:57,440 +End ResultsC-D4 وC-D8 تجارب تلينفوسية تتعرف على + +142 +00:11:57,440 --> 00:12:04,540 +الانتجين على مكان ثلاث مصادر تبعًا مجتمعًا لجميع + +143 +00:12:04,540 --> 00:12:09,720 +الانتجين كما تشاهدون + +144 +00:12:09,720 --> 00:12:16,740 +يوم التلينفوسية تتعرف على الانتجين التجارب الوحيدة + +145 +00:12:16,740 --> 00:12:24,440 +لجميع الانتجينوالتعرف يساعد على CD4 وCD8 100% + +146 +00:12:24,440 --> 00:12:30,100 +بالإضافة إلى ارتباط TCR بالانتجين ياله فيه ان CD4 + +147 +00:12:30,100 --> 00:12:34,520 +وCD8 على سطح الخلايا الانفوسايتز هي من يساعد على + +148 +00:12:34,520 --> 00:12:39,840 +ارتباط TCR بالانتجين ايضا وهو زي ما سمينا كو + +149 +00:12:39,840 --> 00:12:42,980 +ريسبتور بيتبت بال invariant invariant and constant + +150 +00:12:42,980 --> 00:12:46,520 +region of mean of MHC class 2 molecule + +151 +00:12:49,630 --> 00:12:54,250 +دعونا نشاهد خصائص TCR Mediated Antigen Recognition + +152 +00:12:54,250 --> 00:12:58,810 +كما تشاهدون عملية + +153 +00:12:58,810 --> 00:13:01,610 +التعرف على الانتجن من خلال ارتباطه بالـ MSC + +154 +00:13:01,610 --> 00:13:09,310 +مليكيول على سطح الخلية وكل كلون محدد + +155 +00:13:09,310 --> 00:13:11,730 +فقط لأنتجن واحد + +156 +00:13:15,540 --> 00:13:18,820 +والـ Antigen recognition is mediated by a specific + +157 +00:13:18,820 --> 00:13:24,320 +domain of TCR طبيعي جدا اللي هو Variable Domain + +158 +00:13:24,320 --> 00:13:29,300 +Variable Region of Alpha Beta اللي هي اللي بتتعرف + +159 +00:13:29,300 --> 00:13:38,960 +على الانتجن وSignaling is induced by CD3Zeta اللي + +160 +00:13:38,960 --> 00:13:42,920 +associated non-covalently بالTCR + +161 +00:13:46,630 --> 00:13:50,270 +TCR طبعا روتين on different T lymphocyte arise + +162 +00:13:50,270 --> 00:13:53,410 +from gene rearrangement اتفقنا ما ينطبق على ال T + +163 +00:13:53,410 --> 00:13:58,170 +lymphocyte او ال PCR ينطبق على ال TCR في عندنا + +164 +00:13:58,170 --> 00:14:02,670 +توابلي بيبتعد Alpha و Beta Alpha خلّينا نشبهها بال + +165 +00:14:02,670 --> 00:14:05,950 +lighted chain تبع ال Minoglobulin و Beta هي ال + +166 +00:14:05,950 --> 00:14:09,330 +heavy chain فطبعا في ال lighted chain في عندنا two + +167 +00:14:09,330 --> 00:14:12,250 +gene segment هي ال variable و ال joining مرتبط + +168 +00:14:12,250 --> 00:14:16,780 +بمينبالـ Constant Gene بسله بعدين Rearrangement + +169 +00:14:16,780 --> 00:14:24,260 +برضه مرتبط بإيش بالـ Constant Gene ماشي ال هنا + +170 +00:14:24,260 --> 00:14:30,940 +Variable Joining مرتبط في مين؟ في Constant إيش؟ + +171 +00:14:30,940 --> 00:14:37,920 +Constant Gene طبعا بالمقابل ال Beta ده هيفيها + +172 +00:14:37,920 --> 00:14:41,520 +تلاتة genes segment الـ variable و ال diversity هي + +173 +00:14:41,520 --> 00:14:46,620 +واحد و اتنين ثم ال joining ماشي و مرتبطين ب + +174 +00:14:46,620 --> 00:14:52,060 +constant a,b,c,d gene لكن واحد اتنين they are the + +175 +00:14:52,060 --> 00:14:56,660 +same ايه و بعدين بيصير في rearrangement صار في عند + +176 +00:14:56,660 --> 00:15:01,320 +ال rearrangement ل ال beta وصار rearrangement ل ال + +177 +00:15:01,320 --> 00:15:04,920 +alpha اتنين طبعا بيصير الحماشtranscription + +178 +00:15:04,920 --> 00:15:11,820 +وtranslation ويكونوني الـ TCR as alpha beta اللي + +179 +00:15:11,820 --> 00:15:18,440 +هو polypeptide chain بيصير فيه allylic exclusion + +180 +00:15:18,440 --> 00:15:23,760 +زي ما صار في مين في ال PCR بمعنى انه each + +181 +00:15:23,760 --> 00:15:31,680 +individual بياخد من الأم او من الأب alpha chain + +182 +00:15:31,680 --> 00:15:39,450 +gene100% وهو طبعا عملية ال recombination بتتم من + +183 +00:15:39,450 --> 00:15:46,030 +خلال ارتباط ال variable بال joining عشان يكونوا + +184 +00:15:46,030 --> 00:15:52,330 +Alpha في ال maternal او لو مش كون ال maternal + +185 +00:15:52,330 --> 00:15:59,370 +عملية الارتباط productive ماشي خلاص ال + +186 +00:15:59,370 --> 00:16:03,500 +recombinationاللي موجود على ال paternal بيسمله + +187 +00:16:03,500 --> 00:16:08,740 +shut off وضل هذا شغال إذا صار نانو productive فان + +188 +00:16:08,740 --> 00:16:13,540 +بيصير ناخد من ال paternal يبقى وان ال chromosome + +189 +00:16:13,540 --> 00:16:17,400 +is only used وإن كان من ال maternal أو ال paternal + +190 +00:16:17,400 --> 00:16:20,900 +this will prevent individual cell from expressing + +191 +00:16:20,900 --> 00:16:26,900 +more than one TCR أكتر من TCR ماشي هذا هو مواد + +192 +00:16:26,900 --> 00:16:30,700 +الكلام شوفنا في إيش في ال PCR + +193 +00:16:32,150 --> 00:16:36,510 +طيب قصة ال TCR rearrangement اللي بيصير في ال + +194 +00:16:36,510 --> 00:16:43,430 +Thymus احنا اتفقنا انه هي الخلايا ال T cell في + +195 +00:16:43,430 --> 00:16:48,030 +مراحل مبكرة جدا اللي هو Progenitor Thymocytes + +196 +00:16:48,030 --> 00:16:53,590 +بيسموها بتنتقل إلى مين إلى الغدة اللي هي Thymus + +197 +00:16:53,590 --> 00:16:57,210 +اللي هي منطقة فوق الجنب فوق + +198 +00:17:04,410 --> 00:17:09,790 +وTCL تتحرك من بولمار وتجه الـ Thymus في الـ Thymus + +199 +00:17:09,790 --> 00:17:18,390 +هناك مثلها اللي هو Rearrangement للـ TCR و اللي + +200 +00:17:18,390 --> 00:17:23,450 +بعد هي كذا طبعا تنضج الخلية و تطلع من الـ Thymus و + +201 +00:17:23,450 --> 00:17:26,870 +تطلع الـ Peripheral Blood ثم Secondary Lymphoid + +202 +00:17:26,870 --> 00:17:33,350 +Organ looking for Antigenماذا يحدث في هذه العملية؟ + +203 +00:17:33,350 --> 00:17:39,550 +يحدث نيجاتيب و Positive Selection ببساطة نحكي + +204 +00:17:39,550 --> 00:17:42,790 +العملية ببساطة ال positive selection انه في بداية + +205 +00:17:42,790 --> 00:17:50,750 +القمر ال T cell بيتقدم لها ال MSC molecule + +206 +00:17:54,000 --> 00:17:58,060 +بتتعرف عليه اللي بترتبط فيه إذا تعرفت عليه ورتبطت + +207 +00:17:58,060 --> 00:18:01,420 +فيه بتعيش زي ما اتعرفت عليه طول ضائب اياه موتوشيز + +208 +00:18:01,420 --> 00:18:06,020 +وسموا هذه العملية positive selection and it's + +209 +00:18:06,020 --> 00:18:11,240 +usually ال ال + +210 +00:18:11,240 --> 00:18:14,680 +telophosite اللي بتضل هي أبدا تيلوفوسيات الفاعلة + +211 +00:18:14,680 --> 00:18:17,800 +التي لا تتعرف علينا زي ما عمنا نشوفه على self + +212 +00:18:17,800 --> 00:18:23,760 +antigen زي ما انتوا شايفين هي TCRماشي تقدمي لها + +213 +00:18:23,760 --> 00:18:29,640 +الانتيجين اللي هو ال MSC موليكيول مرتبط ببيبتاين + +214 +00:18:29,640 --> 00:18:34,880 +تتعرف عليه ال T lymphocytes و بترتبط فيه و اذا + +215 +00:18:34,880 --> 00:18:42,800 +رتبطت it will ASP survive و نسمي هذه العملية + +216 +00:18:42,800 --> 00:18:47,060 +positive selection وبالتالي ال positive selection + +217 +00:18:47,060 --> 00:18:51,630 +ensure that T cell is capableof interacting with + +218 +00:18:51,630 --> 00:18:59,410 +peptide MHC complex ماشي it will remain alive and + +219 +00:18:59,410 --> 00:19:05,290 +it will recognize it in the future ماشي طبعا هذا + +220 +00:19:05,290 --> 00:19:10,310 +بتقدم ل CD4 او + +221 +00:19:10,310 --> 00:19:14,270 +CD8 CD4 + +222 +00:19:14,270 --> 00:19:22,220 +developed in the basis of the abilityأو TCR تتعامل + +223 +00:19:22,220 --> 00:19:26,100 +مع MSC Class 2 بشكل طبيعي جدا قدرته على ارتباط + +224 +00:19:26,100 --> 00:19:30,240 +طبعا + +225 +00:19:30,240 --> 00:19:37,380 +TCR طبعا اللي T + +226 +00:19:37,380 --> 00:19:42,460 +Cell ارتبطت بال Class 1 Peptidereserve expression + +227 +00:19:42,460 --> 00:19:48,480 +of CD8 وبتفقد منه CD4 يعني اللي مسكت اللي شغلت ال + +228 +00:19:48,480 --> 00:19:51,060 +MSC class 1 هذا هي + +229 +00:19:57,820 --> 00:20:03,000 +يعني بيبقى على سطحها اللي هو CD8 و بتفقد ال CD4 و + +230 +00:20:03,000 --> 00:20:09,380 +العكس طبعا ليه؟ ارتبطت بال MSC Class 2 ماشي بتحتفظ + +231 +00:20:09,380 --> 00:20:17,840 +بال CD4 و تفقد منه ال CD8 تاني ال CD8 بي develop + +232 +00:20:17,840 --> 00:20:21,120 +on the ability of TCR to interact with MSC Class 1 + +233 +00:20:21,120 --> 00:20:21,640 +ماشي + +234 +00:20:26,220 --> 00:20:29,720 +طبعا تي سي ار اللي دونات ريكنيز عمل سي موليكيول + +235 +00:20:29,720 --> 00:20:33,400 +تول دايب ايام اكتروسيز وسموه failure of positive + +236 +00:20:33,400 --> 00:20:41,300 +selection طبعا هذا ال type of selection to weed + +237 +00:20:41,300 --> 00:20:47,500 +out a TCR that cannot + +238 +00:20:51,010 --> 00:20:55,410 +or incapable of detecting msc class one or msc + +239 +00:20:55,410 --> 00:21:05,870 +antigen complex negative + +240 +00:21:05,870 --> 00:21:11,990 +selection طبعا بعد هي تنزل deep في المنطقة تارطبات + +241 +00:21:11,990 --> 00:21:16,660 +ال cortex بالمضالة وهناك برضه بتقدم لهاالـ Antigen + +242 +00:21:16,660 --> 00:21:21,820 +مرة تانية لما شي موليكيول مرتبط بفرن بـ Self + +243 +00:21:21,820 --> 00:21:26,260 +-antigen وطبعا الخلايا التي تتعرف عليها أو تتطبط + +244 +00:21:26,260 --> 00:21:29,960 +فيها it will die by apoptosis انما الخلايا التي لا + +245 +00:21:29,960 --> 00:21:34,000 +تتطبط فيها أو تتعرف عليها it will survive لأنه + +246 +00:21:34,000 --> 00:21:37,940 +مطلوب منها في هذه المرحلة انها تتعرف على الـ Self + +247 +00:21:37,940 --> 00:21:42,100 +-antigen ولا تتفاعل معاه ويسمو هذه الخطوة Self-non + +248 +00:21:42,100 --> 00:21:43,100 +-self discrimination + +249 +00:21:55,890 --> 00:22:02,670 +الجسم يقوم بإزالة خلية + +250 +00:22:02,670 --> 00:22:08,190 +من الانفوسايتات + +251 +00:22:08,190 --> 00:22:11,880 +بشكل اكتر بشكل اكترطبعا الـ Thymocyte maturation + +252 +00:22:11,880 --> 00:22:20,000 +مشير في مراتين مختلفة وهذا عبارة عن رابط من وجود + +253 +00:22:20,000 --> 00:22:25,600 +في مراتين مختلفة ليش + +254 +00:22:25,600 --> 00:22:29,660 +العملية يعني شو محصلتها قالوا positive selection + +255 +00:22:29,660 --> 00:22:37,480 +بعمل MRC restrictionلكن ليش؟ هذا بيؤدى ويؤكد على + +256 +00:22:37,480 --> 00:22:40,780 +ان الـ CD8-T-Lymphocyte is specific for MSC Class + +257 +00:22:40,780 --> 00:22:44,160 +I وان الـ CD4-T-Lymphocyte is specific only for + +258 +00:22:44,160 --> 00:22:49,260 +MSC Class II بيبتاية الكمبليكس negative selection + +259 +00:22:49,260 --> 00:22:54,600 +remove self-reactive اللي شو بيصير بعد هيك؟ كانوا + +260 +00:22:54,600 --> 00:22:58,180 +الـ T-Lymphocyte migrate من الـ Thyme تطلع من الـ + +261 +00:22:58,180 --> 00:23:02,200 +Thyme على البريفرالينفويد organs و looking for + +262 +00:23:02,200 --> 00:23:08,490 +أيش؟بحث عن الـ Antigen اللي مرتبط باما class 1 او + +263 +00:23:08,490 --> 00:23:13,750 +اما class 2 وبعد ذلك بيصبح لها Clonally Expanded + +264 +00:23:13,750 --> 00:23:17,350 +هل + +265 +00:23:17,350 --> 00:23:20,350 +هو ال Antigen presentation كل هذا ولا خلاص فيه اشي + +266 +00:23:20,350 --> 00:23:27,560 +تاني طبعا قالوا لأعملية ال activation بيصير فيها + +267 +00:23:27,560 --> 00:23:30,860 +اشي تاني زي ما انتوا شايفين تحتاج الى two signal + +268 +00:23:30,860 --> 00:23:36,140 +الأولاني هو الاشي بتقدم ال antigen على سطح ال + +269 +00:23:36,140 --> 00:23:39,240 +مرتبط الأمسي مليكيول على سطح ال antigen presenting + +270 +00:23:39,240 --> 00:23:45,240 +cell one مثال على class two وهي ال antigen وهي ال + +271 +00:23:45,240 --> 00:23:49,040 +telemphosites ماشي ثم CD4 + +272 +00:23:56,350 --> 00:24:04,830 +ماشي طبعا ال CD4 مرتبط + +273 +00:24:04,830 --> 00:24:08,630 +في ال constant region of MSC class 2 بس مش واضحة + +274 +00:24:08,630 --> 00:24:12,550 +في الصورة هنا لكن هنا عايش اللي واضح انه we need + +275 +00:24:12,550 --> 00:24:15,590 +second signal we need second signal وهي ال second + +276 +00:24:15,590 --> 00:24:19,670 +signal تكونات ده هو ال cost stimulation يبقى الأول + +277 +00:24:19,670 --> 00:24:23,440 +ان هي الارتباط بال أنتجل التاني عايشالذي هو الـ + +278 +00:24:23,440 --> 00:24:26,640 +Second Signal وهي برضه الـ Co-stimulatory reaction + +279 +00:24:26,640 --> 00:24:35,720 +CD28-V7 1 أو 2 ماشي يتم الارتباط ويقوي الرابطة في + +280 +00:24:35,720 --> 00:24:41,120 +هذه الحالة هذه Co-stimulatory reaction هذا هي + +281 +00:24:41,120 --> 00:24:44,420 +listing antigen presenting cell to not express Co + +282 +00:24:44,420 --> 00:24:49,680 +-stimulation طبيعي جدا أي خلية جاعدة ما بتعمل ما + +283 +00:24:49,680 --> 00:24:50,980 +بتكون Co-stimulators + +284 +00:24:53,320 --> 00:25:02,260 +حتى وإن كانت مرتبطة بمين ب بيبتايد أنتيجن نهير + +285 +00:25:02,260 --> 00:25:05,060 +T cell that encounter antigen in the absence of + +286 +00:25:05,060 --> 00:25:08,920 +costimulator become anergic غياب ال costimulatory + +287 +00:25:08,920 --> 00:25:14,440 +bonding بيعمل بيخلق الخلية مشلولة anergic cell + +288 +00:25:14,440 --> 00:25:20,680 +يعني مشلولة لاتت نشط انما اللي يحصل فيه نشاط فده + +289 +00:25:20,680 --> 00:25:27,180 +هوهذا هي يوم يكون فيه ارتباط يوم يكون فيه foreign + +290 +00:25:27,180 --> 00:25:33,340 +antigen يصير الارتباط الأولاني ماشي مع ال TCR ثم + +291 +00:25:33,340 --> 00:25:39,800 +CD28 مع ال B7 ثم يصير فيه release to cytokine ماشي + +292 +00:25:39,800 --> 00:25:43,160 +تتنشط اللي هو T lymphocytes اللي بتفرد ال cytokine + +293 +00:25:43,160 --> 00:25:48,520 +ومن نشط الخلق ال cytokine اللي طالع هو هنا في هذا + +294 +00:25:48,520 --> 00:25:52,060 +الحالة IL-12 عشان ينشط يعني جاي من Macrophage + +295 +00:25:53,430 --> 00:25:58,730 +الخلايا الموجودة على سطح + +296 +00:25:58,730 --> 00:26:05,970 +التيلينفوسايت ويزودونها بشكل ثانوي لإكتماع + +297 +00:26:05,970 --> 00:26:07,950 +تلينفوسايت ومتما يحصل اكتماع تلينفوسايت يحصل + +298 +00:26:07,950 --> 00:26:12,290 +اكتماع تلينفوسايت ومتما يحصل اكتماع تلينفوسايت + +299 +00:26:12,290 --> 00:26:14,850 +يحصل + +300 +00:26:16,460 --> 00:26:19,600 +ليس فقط فرصة واحدة فرصة واحدة فرصة واحدة فرصة + +301 +00:26:19,600 --> 00:26:32,340 +واحدة فرصة واحدة فرصة واحدة + +302 +00:26:32,340 --> 00:26:41,900 +فرصة + +303 +00:26:41,900 --> 00:26:45,560 +واحدة + +304 +00:26:46,330 --> 00:26:52,010 +لا توجد إجابة أو إفعالية أو إفعالية حتى إذا كانت + +305 +00:26:52,010 --> 00:26:54,230 +موجودة في مستوى التواصل الانتجيني الذي يمكنه إعطاء + +306 +00:26:54,230 --> 00:27:01,210 +الثانوية إشارة لا يمكن تفعيلها إذا كانت موجودة + +307 +00:27:01,210 --> 00:27:01,230 +في مستوى التواصل الانتجيني الذي يمكن تفعيلها إذا + +308 +00:27:01,230 --> 00:27:01,970 +كانت موجودة في مستوى التواصل الانتجيني الذي يمكن + +309 +00:27:01,970 --> 00:27:03,310 +تفعيلها إذا كانت موجودة في مستوى التواصل الانتجيني + +310 +00:27:03,310 --> 00:27:06,750 +الذي يمكن تفعيلها إذا كانت موجودة في مستوى التواصل + +311 +00:27:06,750 --> 00:27:10,510 +الانتجيني الذي يمكن تفعيلها إذا كانت موجودة في + +312 +00:27:10,510 --> 00:27:13,130 +مستوى التواصل الانتتحفز وان الانتجن الـ T-cell + +313 +00:27:13,130 --> 00:27:14,210 +انتجن الـ T-cell انتجن الـ T-cell انتجن الـ T-cell + +314 +00:27:14,210 --> 00:27:14,930 +انتجن الـ T-cell انتجن الـ T-cell انتجن الـ T-cell + +315 +00:27:14,930 --> 00:27:17,030 +انتجن الـ T-cell انتجن الـ T-cell انتجن الـ T-cell + +316 +00:27:17,030 --> 00:27:21,490 +انتجن الـ T-cell انتجن الـ T-cell انتجن الـ T-cell + +317 +00:27:21,490 --> 00:27:23,790 +انتجن الـ T-cell انتجن الـ T-cell انتجن الـ T-cell + +318 +00:27:23,790 --> 00:27:27,420 +انتجن الـ T-cell انتجن الـ T-cell انسلحة مسكت فيه + +319 +00:27:27,420 --> 00:27:33,160 +ماشي هرتبطت و بيصير simultaneous detection of + +320 +00:27:33,160 --> 00:27:36,000 +foreign antigen and second signal activity cell + +321 +00:27:36,000 --> 00:27:40,420 +and drive subsequent immune response يقبل تمسك في + +322 +00:27:40,420 --> 00:27:44,680 +سلفة انتجين هدا هي مسكت في سلفة انتجين بس انها هي + +323 +00:27:44,680 --> 00:27:50,130 +ايش tolerance او deletion or allergyهذا الكلام + +324 +00:27:50,130 --> 00:27:58,250 +مصير في ايه؟ في اللي هو ال second .. + +325 +00:27:58,250 --> 00:28:01,110 +في غياب ال second signal resting antigen + +326 +00:28:01,110 --> 00:28:03,530 +presenting cell express little or no cost + +327 +00:28:03,530 --> 00:28:09,530 +stimulation and display self-antigenوبالتالي + +328 +00:28:09,530 --> 00:28:12,830 +مرتبطة بتكون الـ self-antigen وبالتالي لا تنشد T + +329 +00:28:12,830 --> 00:28:15,690 +-Lymphocytes as a result T-Lymphocytes become + +330 +00:28:15,690 --> 00:28:19,230 +energetic and there is no longer capable of + +331 +00:28:19,230 --> 00:28:21,750 +mediating immune response مافي إمكانية تعملنا + +332 +00:28:21,750 --> 00:28:25,610 +immune response thus energy serve as an important + +333 +00:28:25,610 --> 00:28:30,710 +safeguard هي مرحلة بوابة أمان ماشية against + +334 +00:28:30,710 --> 00:28:36,110 +autoimmunity in the peripheryطبعا هنا زي ما انتوا + +335 +00:28:36,110 --> 00:28:39,970 +شايفين الـ two signal لازمين are required to + +336 +00:28:39,970 --> 00:28:44,770 +activate T cell but only one for the activated + +337 +00:28:44,770 --> 00:28:49,630 +match was cell to function يعني لخلية نايف بدنا + +338 +00:28:49,630 --> 00:28:55,070 +two signal للمatch و one signal is enoughماشي هي + +339 +00:28:55,070 --> 00:28:58,930 +عبارة عن mature signal واحدة صار في ايش الارتباط + +340 +00:28:58,930 --> 00:29:03,950 +ايه فصار في الهو direct killing mature direct + +341 +00:29:03,950 --> 00:29:08,450 +killing هنا لكن هي نايف نايف نايف نايف نايف نايف + +342 +00:29:08,450 --> 00:29:08,930 +نايف نايف نايف نايف نايف نايف نايف نايف نايف نايف + +343 +00:29:08,930 --> 00:29:12,330 +نايف + +344 +00:29:12,330 --> 00:29:14,470 +نايف نايف نايف نايف نايف نايف نايف نايف نايف نايف + +345 +00:29:14,470 --> 00:29:20,330 +نايف نايف نايف نايف نايف نايف نايف نايف نايف نايف + +346 +00:29:20,330 --> 00:29:20,570 +نايف نايف نايف نايف نايف نايف نايف نايف نايف نايف + +347 +00:29:20,570 --> 00:29:20,610 +نايف نايف نايف نايف نايف نايف نايف نايف نايف نايف + +348 +00:29:20,610 --> 00:29:29,150 +نايف نايف نايف نأرجو أن تكونوا قد أفدتم لها بإذن + +349 +00:29:29,150 --> 00:29:29,390 +الله + diff --git a/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/W_p3egjnWxo_raw.json b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/W_p3egjnWxo_raw.json new file mode 100644 index 0000000000000000000000000000000000000000..2374af8d4222b107fc087e423a8e4c0f0b0b1046 --- /dev/null +++ b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/W_p3egjnWxo_raw.json @@ -0,0 +1 @@ +{"segments": [{"id": 1, "seek": 3025, "start": 3.19, "end": 30.25, "text": "عندما اتفقنا المحاضرة 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5.960464477539063e-08, "words": [{"start": 1226.22, "end": 1226.56, "word": "طبعا", "probability": 0.7505111694335938}, {"start": 1226.56, "end": 1226.82, "word": " تي", "probability": 0.218994140625}, {"start": 1226.82, "end": 1226.98, "word": " سي", "probability": 0.944091796875}, {"start": 1226.98, "end": 1227.22, "word": " ار", "probability": 0.56982421875}, {"start": 1227.22, "end": 1227.74, "word": " اللي", "probability": 0.721435546875}, {"start": 1227.74, "end": 1228.14, "word": " دونات", "probability": 0.460205078125}, {"start": 1228.14, "end": 1228.7, "word": " ريكنيز", "probability": 0.61103515625}, {"start": 1228.7, "end": 1228.94, "word": " عمل", "probability": 0.53509521484375}, {"start": 1228.94, "end": 1229.2, "word": " سي", "probability": 0.54010009765625}, {"start": 1229.2, "end": 1229.72, "word": " موليكيول", "probability": 0.66070556640625}, {"start": 1229.72, "end": 1229.94, "word": " تول", "probability": 0.54638671875}, {"start": 1229.94, "end": 1230.26, "word": " دايب", "probability": 0.5658365885416666}, {"start": 1230.26, "end": 1230.5, "word": " ايام", "probability": 0.558349609375}, {"start": 1230.5, "end": 1231.1, "word": " اكتروسيز", "probability": 0.6740025111607143}, {"start": 1231.1, "end": 1232.36, "word": " وسموه", "probability": 0.6728515625}, {"start": 1232.36, "end": 1232.68, "word": " failure", "probability": 0.382568359375}, {"start": 1232.68, "end": 1233.02, "word": " of", "probability": 0.93017578125}, {"start": 1233.02, "end": 1233.4, "word": " positive", "probability": 0.85986328125}, {"start": 1233.4, "end": 1234.1, "word": " selection", "probability": 0.91552734375}, {"start": 1234.1, "end": 1236.92, "word": " طبعا", "probability": 0.9610595703125}, {"start": 1236.92, "end": 1237.94, "word": " هذا", "probability": 0.77783203125}, {"start": 1237.94, "end": 1239.68, "word": " ال", "probability": 0.9326171875}, {"start": 1239.68, "end": 1239.96, "word": " type", "probability": 0.7685546875}, {"start": 1239.96, "end": 1240.12, "word": " of", "probability": 0.96142578125}, {"start": 1240.12, "end": 1240.64, "word": " selection", "probability": 0.927734375}, {"start": 1240.64, "end": 1240.86, "word": " to", "probability": 0.428466796875}, {"start": 1240.86, "end": 1241.3, "word": " weed", "probability": 0.89013671875}, {"start": 1241.3, "end": 1243.4, "word": " out", "probability": 0.8349609375}, {"start": 1243.4, "end": 1243.86, "word": " a", "probability": 0.483154296875}, {"start": 1243.86, "end": 1244.42, "word": " TCR", "probability": 0.854248046875}, {"start": 1244.42, "end": 1244.9, "word": " that", "probability": 0.841796875}, {"start": 1244.9, "end": 1247.5, "word": " cannot", "probability": 0.54296875}], "temperature": 1.0}, {"id": 49, "seek": 127510, "start": 1251.01, "end": 1275.11, "text": "or incapable of detecting msc class one or msc antigen complex negative selection طبعا بعد هي تنزل deep في المنطقة تارطبات ال cortex بالمضالة وهناك برضه بتقدم لها", "tokens": [284, 44174, 295, 40237, 275, 4417, 1508, 472, 420, 275, 4417, 2511, 3213, 3997, 3671, 9450, 23032, 3555, 3615, 995, 39182, 39896, 6055, 1863, 11622, 1211, 2452, 8978, 9673, 1863, 9566, 28671, 6055, 9640, 9566, 3555, 9307, 2423, 33312, 20666, 2304, 11242, 6027, 3660, 37037, 8315, 4117, 4724, 43042, 3224, 39894, 28543, 2304, 5296, 11296], "avg_logprob": -0.39704239794186186, "compression_ratio": 1.345679012345679, "no_speech_prob": 0.0, "words": [{"start": 1251.01, "end": 1251.45, "word": "or", "probability": 0.0623779296875}, {"start": 1251.45, "end": 1252.13, "word": " incapable", "probability": 0.51611328125}, {"start": 1252.13, "end": 1252.63, "word": " of", "probability": 0.96923828125}, {"start": 1252.63, "end": 1253.09, "word": " detecting", "probability": 0.8935546875}, {"start": 1253.09, "end": 1253.79, "word": " msc", "probability": 0.27386474609375}, {"start": 1253.79, "end": 1254.17, "word": " class", "probability": 0.802734375}, {"start": 1254.17, "end": 1254.63, "word": " one", "probability": 0.424560546875}, {"start": 1254.63, "end": 1254.95, "word": " or", "probability": 0.3359375}, {"start": 1254.95, "end": 1255.41, "word": " msc", "probability": 0.82373046875}, {"start": 1255.41, "end": 1255.87, "word": " antigen", "probability": 0.791259765625}, {"start": 1255.87, "end": 1256.55, "word": " complex", "probability": 0.9287109375}, {"start": 1256.55, "end": 1265.87, "word": " negative", "probability": 0.5283203125}, {"start": 1265.87, "end": 1266.49, "word": " selection", "probability": 0.94287109375}, {"start": 1266.49, "end": 1266.85, "word": " طبعا", "probability": 0.81573486328125}, {"start": 1266.85, "end": 1267.07, "word": " بعد", "probability": 0.626953125}, {"start": 1267.07, "end": 1267.23, "word": " هي", "probability": 0.814453125}, {"start": 1267.23, "end": 1268.55, "word": " تنزل", "probability": 0.8704833984375}, {"start": 1268.55, "end": 1269.39, "word": " deep", "probability": 0.5693359375}, {"start": 1269.39, "end": 1269.61, "word": " في", "probability": 0.86181640625}, {"start": 1269.61, "end": 1271.23, "word": " المنطقة", "probability": 0.91162109375}, {"start": 1271.23, "end": 1271.99, "word": " تارطبات", "probability": 0.560986328125}, {"start": 1271.99, "end": 1272.15, "word": " ال", "probability": 0.74609375}, {"start": 1272.15, "end": 1272.61, "word": " cortex", "probability": 0.84716796875}, {"start": 1272.61, "end": 1273.39, "word": " بالمضالة", "probability": 0.7271484375}, {"start": 1273.39, "end": 1273.91, "word": " وهناك", "probability": 0.81396484375}, {"start": 1273.91, "end": 1274.15, "word": " برضه", "probability": 0.8621419270833334}, {"start": 1274.15, "end": 1274.73, "word": " بتقدم", "probability": 0.8450520833333334}, {"start": 1274.73, "end": 1275.11, "word": " لها", "probability": 0.74609375}], "temperature": 1.0}, {"id": 50, "seek": 130309, "start": 1275.68, "end": 1303.1, "text": "الـ Antigen مرة تانية لما شي موليكيول مرتبط بفرن بـ Self-antigen وطبعا الخلايا التي تتعرف عليها أو تتطبط فيها it will die by apoptosis انما الخلايا التي لا تتطبط فيها أو تتعرف عليها it will survive لأنه مطلوب منها في هذه المرحلة انها تتعرف على الـ Self-antigen ولا تتفاعل معاه ويسمو هذه الخطوة Self-non-self discrimination", "tokens": [6027, 39184, 5130, 3213, 3714, 25720, 6055, 7649, 10632, 5296, 15042, 44049, 3714, 12610, 1829, 4117, 1829, 12610, 3714, 43500, 3555, 9566, 4724, 5172, 2288, 1863, 4724, 39184, 16348, 12, 394, 3213, 4032, 9566, 3555, 3615, 995, 33962, 15040, 25528, 38392, 6055, 2655, 3615, 28480, 25894, 11296, 34051, 6055, 2655, 9566, 3555, 9566, 8978, 11296, 309, 486, 978, 538, 1882, 5747, 8211, 16472, 15042, 33962, 15040, 25528, 38392, 20193, 6055, 2655, 9566, 3555, 9566, 8978, 11296, 34051, 6055, 2655, 3615, 28480, 25894, 11296, 309, 486, 7867, 5296, 33456, 3224, 3714, 9566, 1211, 37746, 9154, 11296, 8978, 29538, 9673, 2288, 5016, 37977, 16472, 11296, 6055, 2655, 3615, 28480, 15844, 2423, 39184, 16348, 12, 394, 3213, 49429, 6055, 2655, 5172, 995, 30241, 20449, 40294, 4032, 1829, 38251, 2407, 29538, 33962, 9566, 2407, 3660, 16348, 12, 30092, 12, 927, 15973], "avg_logprob": -0.28306158621242083, "compression_ratio": 1.8689138576779025, "no_speech_prob": 7.808208465576172e-06, "words": [{"start": 1275.68, "end": 1276.14, "word": "الـ", "probability": 0.3634033203125}, {"start": 1276.14, "end": 1276.66, "word": " Antigen", "probability": 0.87255859375}, {"start": 1276.66, "end": 1277.12, "word": " مرة", "probability": 0.9306640625}, {"start": 1277.12, "end": 1277.7, "word": " تانية", "probability": 0.9510091145833334}, {"start": 1277.7, "end": 1278.2, "word": " لما", "probability": 0.7861328125}, {"start": 1278.2, "end": 1278.5, "word": " شي", "probability": 0.265869140625}, {"start": 1278.5, "end": 1279.02, "word": " موليكيول", "probability": 0.72332763671875}, {"start": 1279.02, "end": 1280.0, "word": " مرتبط", "probability": 0.9224853515625}, {"start": 1280.0, "end": 1281.36, "word": " بفرن", "probability": 0.72833251953125}, {"start": 1281.36, "end": 1281.72, "word": " بـ", "probability": 0.578369140625}, {"start": 1281.72, "end": 1281.82, "word": " Self", "probability": 0.5087890625}, {"start": 1281.82, "end": 1282.36, "word": "-antigen", "probability": 0.7457682291666666}, {"start": 1282.36, "end": 1283.88, "word": " وطبعا", "probability": 0.634375}, {"start": 1283.88, "end": 1284.3, "word": " الخلايا", "probability": 0.9410807291666666}, {"start": 1284.3, "end": 1284.54, "word": " التي", "probability": 0.771484375}, {"start": 1284.54, "end": 1285.16, "word": " تتعرف", "probability": 0.978515625}, {"start": 1285.16, "end": 1285.66, "word": " عليها", "probability": 0.997314453125}, {"start": 1285.66, "end": 1285.82, "word": " أو", "probability": 0.436279296875}, {"start": 1285.82, "end": 1286.26, "word": " تتطبط", "probability": 0.758642578125}, {"start": 1286.26, "end": 1286.54, "word": " فيها", "probability": 0.915283203125}, {"start": 1286.54, "end": 1286.68, "word": " it", "probability": 0.1405029296875}, {"start": 1286.68, "end": 1286.78, "word": " will", "probability": 0.89599609375}, {"start": 1286.78, "end": 1287.02, "word": " die", "probability": 0.6943359375}, {"start": 1287.02, "end": 1287.2, "word": " by", "probability": 0.91064453125}, {"start": 1287.2, "end": 1288.12, "word": " apoptosis", "probability": 0.6887410481770834}, {"start": 1288.12, "end": 1288.92, "word": " انما", "probability": 0.555511474609375}, {"start": 1288.92, "end": 1289.4, "word": " الخلايا", "probability": 0.9532877604166666}, {"start": 1289.4, "end": 1289.68, "word": " التي", "probability": 0.791015625}, {"start": 1289.68, "end": 1289.96, "word": " لا", "probability": 0.84716796875}, {"start": 1289.96, "end": 1290.54, "word": " تتطبط", "probability": 0.9765625}, {"start": 1290.54, "end": 1290.8, "word": " فيها", "probability": 0.92138671875}, {"start": 1290.8, "end": 1290.92, "word": " أو", "probability": 0.5556640625}, {"start": 1290.92, "end": 1291.42, "word": " تتعرف", "probability": 0.984130859375}, {"start": 1291.42, "end": 1291.86, "word": " عليها", "probability": 0.9951171875}, {"start": 1291.86, "end": 1292.04, "word": " it", "probability": 0.7666015625}, {"start": 1292.04, "end": 1292.24, "word": " will", "probability": 0.90478515625}, {"start": 1292.24, "end": 1293.18, "word": " survive", "probability": 0.953125}, {"start": 1293.18, "end": 1294.0, "word": " لأنه", "probability": 0.7176106770833334}, {"start": 1294.0, "end": 1294.38, "word": " مطلوب", "probability": 0.957275390625}, {"start": 1294.38, "end": 1294.78, "word": " منها", "probability": 0.968017578125}, {"start": 1294.78, "end": 1295.3, "word": " في", "probability": 0.92333984375}, {"start": 1295.3, "end": 1295.58, "word": " هذه", "probability": 0.9716796875}, {"start": 1295.58, "end": 1296.22, "word": " المرحلة", "probability": 0.9908447265625}, {"start": 1296.22, "end": 1296.82, "word": " انها", "probability": 0.692138671875}, {"start": 1296.82, "end": 1297.42, "word": " تتعرف", "probability": 0.9874267578125}, {"start": 1297.42, "end": 1297.6, "word": " على", "probability": 0.81591796875}, {"start": 1297.6, "end": 1297.78, "word": " الـ", "probability": 0.781982421875}, {"start": 1297.78, "end": 1297.94, "word": " Self", "probability": 0.54150390625}, {"start": 1297.94, "end": 1298.42, "word": "-antigen", "probability": 0.9676106770833334}, {"start": 1298.42, "end": 1298.64, "word": " ولا", "probability": 0.69189453125}, {"start": 1298.64, "end": 1299.38, "word": " تتفاعل", "probability": 0.9640625}, {"start": 1299.38, "end": 1299.72, "word": " معاه", "probability": 0.947509765625}, {"start": 1299.72, "end": 1300.18, "word": " ويسمو", "probability": 0.56805419921875}, {"start": 1300.18, "end": 1300.4, "word": " هذه", "probability": 0.93017578125}, {"start": 1300.4, "end": 1301.0, "word": " الخطوة", "probability": 0.9788818359375}, {"start": 1301.0, "end": 1301.78, "word": " Self", "probability": 0.34912109375}, {"start": 1301.78, "end": 1302.1, "word": "-non", "probability": 0.596923828125}, {"start": 1302.1, "end": 1302.44, "word": "-self", "probability": 0.817626953125}, {"start": 1302.44, "end": 1303.1, "word": " discrimination", "probability": 0.642578125}], "temperature": 1.0}, {"id": 51, "seek": 132819, "start": 1315.89, "end": 1328.19, "text": "الجسم يقوم بإزالة خلية من الانفوسايتات بشكل اكتر بشكل اكتر", "tokens": [6027, 7435, 38251, 7251, 4587, 20498, 4724, 28814, 11622, 6027, 3660, 16490, 1211, 10632, 9154, 2423, 7649, 5172, 41779, 995, 36081, 9307, 4724, 8592, 28820, 1975, 4117, 2655, 2288, 4724, 8592, 28820, 1975, 4117, 2655, 2288], "avg_logprob": -0.9755067180942845, "compression_ratio": 1.3717948717948718, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1315.8899999999999, "end": 1317.29, "word": "الجسم", "probability": 0.3934122721354167}, {"start": 1317.29, "end": 1317.89, "word": " يقوم", "probability": 0.5049641927083334}, {"start": 1317.89, "end": 1318.99, "word": " بإزالة", "probability": 0.62158203125}, {"start": 1318.99, "end": 1322.67, "word": " خلية", "probability": 0.5297648111979166}, {"start": 1322.67, "end": 1322.73, "word": " من", "probability": 0.1253662109375}, {"start": 1322.73, "end": 1328.19, "word": " الانفوسايتات", "probability": 0.46840122767857145}, {"start": 1328.19, "end": 1328.19, "word": " بشكل", "probability": 0.4545491536458333}, {"start": 1328.19, "end": 1328.19, "word": " اكتر", "probability": 0.441925048828125}, {"start": 1328.19, "end": 1328.19, "word": " بشكل", "probability": 0.4228922526041667}, {"start": 1328.19, "end": 1328.19, "word": " اكتر", "probability": 0.8092041015625}], "temperature": 1.0}, {"id": 52, "seek": 135202, "start": 1329.8, "end": 1352.02, "text": "طبعا الـ Thymocyte maturation مشير في مراتين مختلفة وهذا عبارة عن رابط من وجود في مراتين مختلفة ليش العملية يعني شو محصلتها قالوا positive selection بعمل MRC restriction", "tokens": [9566, 3555, 3615, 995, 2423, 39184, 334, 4199, 31078, 975, 3803, 8167, 37893, 13546, 8978, 3714, 2288, 9307, 9957, 3714, 46456, 46538, 3660, 37037, 15730, 6225, 3555, 9640, 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هنا عايش اللي واضح انه we need second signal we need second signal وهي ال second signal تكونات ده هو ال cost stimulation يبقى الأول ان هي الارتباط بال أنتجل التاني عايش", "tokens": [2304, 33599, 1829, 23032, 3555, 3615, 995, 2423, 6743, 19, 3714, 43500, 3555, 9566, 8978, 2423, 5754, 4458, 295, 7395, 34, 1508, 568, 4724, 3794, 37893, 4032, 46958, 5016, 3660, 8978, 31767, 13063, 3660, 34105, 44381, 34105, 6225, 47302, 8592, 13672, 1829, 4032, 46958, 5016, 16472, 3224, 321, 643, 1150, 6358, 321, 643, 1150, 6358, 37037, 1829, 2423, 1150, 6358, 6055, 4117, 2407, 8315, 2655, 11778, 3224, 31439, 2423, 2063, 37405, 7251, 3555, 4587, 7578, 16247, 12610, 16472, 39896, 2423, 9640, 2655, 3555, 41193, 20666, 14739, 2655, 7435, 1211, 16712, 7649, 1829, 6225, 47302, 8592], "avg_logprob": -0.3234049351885915, "compression_ratio": 1.6120689655172413, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 1436.35, "end": 1437.05, "word": "ماشي", "probability": 0.6289876302083334}, {"start": 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مليكيول بيتكوّم into polypeptide + +6 +00:00:28,050 --> 00:00:30,250 +chain هي Alpha و Beta + +7 +00:00:33,170 --> 00:00:41,530 +كل واحدة منهم تحتوي على two domain الفجر + +8 +00:00:41,530 --> 00:00:47,170 +هذه variable براني يعني واللي + +9 +00:00:47,170 --> 00:00:51,370 +قريب من ال cell membrane هو ال constant region + +10 +00:00:51,370 --> 00:00:56,630 +يعني عندنا هذا هو ال variable هو بران V Alpha V + +11 +00:00:56,630 --> 00:01:03,000 +Betaوالـ constant هو عبارة عن C α C بيتا يبقى فيه + +12 +00:01:03,000 --> 00:01:05,480 +variable وفيه constant region وفيه Trans membrane + +13 +00:01:05,480 --> 00:01:11,300 +area وفيه short cytoplasmic tail ماشي they are + +14 +00:01:11,300 --> 00:01:15,340 +connected with each other by disulfide bond ماشي + +15 +00:01:15,340 --> 00:01:19,560 +disulfide bond طبعا فيه هنا بعتبر هذه المنطقة + +16 +00:01:19,560 --> 00:01:23,260 +عبارة عن hinge region وهنا بنشوف variable و + +17 +00:01:23,260 --> 00:01:28,020 +constant region are similar in structureلأ طبعا + +18 +00:01:28,020 --> 00:01:34,360 +antibody للي كان موجود في ال antibody نفس الحكاية + +19 +00:01:34,360 --> 00:01:37,980 +ال variable هي مسئولة عن ال antigen recognition + +20 +00:01:37,980 --> 00:01:45,940 +بينما ال constant مالهاش أي وظيفة هنا غير الارتباط + +21 +00:01:45,940 --> 00:01:49,680 +بال coreceptor molecule على سطح دي الأمفوسايت + +22 +00:01:55,860 --> 00:02:00,600 +بالمقارنة مع الانتيبادي الانتيبادي يمكن أن يكون + +23 +00:02:00,600 --> 00:02:03,520 +وجده في اتجاراتين واحدة مخفضة وواحدة مخفضة على + +24 +00:02:03,520 --> 00:02:06,440 +بلازمة الممبريل لكن ال TCR هو دائما موجود على + +25 +00:02:06,440 --> 00:02:11,760 +مخفضة بلازمة الممبريل ليس مخفضا هذا مقارنة ما بين + +26 +00:02:11,760 --> 00:02:16,000 +الانتيبادي وما بين ال TCR كما تشاهدون الاتنين + +27 +00:02:16,000 --> 00:02:18,700 +عندهم اتجارة + +28 +00:02:20,250 --> 00:02:24,070 +اللي بتحتوي على variable و على constant domain + +29 +00:02:24,070 --> 00:02:28,810 +variable و constant domain و طبعا متفقين على ان ال + +30 +00:02:28,810 --> 00:02:34,730 +variable هي ال V region و ال constant ده هي ال C + +31 +00:02:34,730 --> 00:02:38,250 +region طبعا في ال immunoglobulin في أنها ال + +32 +00:02:38,250 --> 00:02:43,030 +variable و هدولها ال constant variable constant و + +33 +00:02:43,030 --> 00:02:47,870 +هكذا و طبعا both have hinge region هي ال hinge + +34 +00:02:47,870 --> 00:02:52,790 +region هان و هانالانتباد يجعل الموليكيو مستقل، + +35 +00:02:52,790 --> 00:02:57,190 +وكذلك في الـTCR، + +36 +00:02:57,190 --> 00:03:04,090 +الموليكيو مستقل، وكذلك في الـTCR، الموليكيو مستقل، + +37 +00:03:04,090 --> 00:03:08,870 +وكذلك في الـTCR، الموليكيو مستقل، وكذلك في الـTCR، + +38 +00:03:08,870 --> 00:03:12,530 +الموليكيو مستقل، وكذلك في الـTCR، الموليكيو مستقل، + +39 +00:03:12,530 --> 00:03:15,730 +وكذلك في الـTCR، الموليكيو مستقل، وكذلك في الـTCR، + +40 +00:03:15,730 --> 00:03:16,130 +الموليكيو مستقل، وكذلك في الـTCR، الموليكيو مستقل، + +41 +00:03:16,130 --> 00:03:19,070 +وكذلك في الـTCR، الموليكيو مستقل، وكذلك في الـTCR، + +42 +00:03:19,070 --> 00:03:21,990 +الموليكيومقاله هنا Any of vector function وبالتالي + +43 +00:03:21,990 --> 00:03:27,770 +ما بخش في ال signal signal transduction طيب ال .. + +44 +00:03:27,770 --> 00:03:32,790 +برضه قررنا تنبع ال antibody و ال TCR و نشوف في ال + +45 +00:03:32,790 --> 00:03:36,330 +antigen recognition هذا عبارة عن antibody و هذا + +46 +00:03:36,330 --> 00:03:41,510 +عبارة عن TCR antibody موجود هو عبارة عن PCR ده هو + +47 +00:03:41,510 --> 00:03:46,450 +antibody is anchored on the cell membraneهو مرتبط + +48 +00:03:46,450 --> 00:03:49,930 +فيه بجانبه + +49 +00:03:49,930 --> 00:03:53,250 +نهر موليكيول بيسموه Menoglobulin Alpha + +50 +00:03:53,250 --> 00:03:55,410 +وMenoglobulin Beta هو المسؤول عن Signal + +51 +00:03:55,410 --> 00:04:04,990 +Transduction بينما في ال TCRعشان يتم التعرف على + +52 +00:04:04,990 --> 00:04:09,610 +الانتجن، يجب أن يكون الانتجن مقدم للـ TCR أو الـ T + +53 +00:04:09,610 --> 00:04:12,830 +-cell من خلال الـ Antigen Presenting Cell الهدهية + +54 +00:04:12,830 --> 00:04:17,670 +على سطح MLC مليكيوري مرتبط بالانتجن، والـ TCR + +55 +00:04:17,670 --> 00:04:20,530 +مرتبط بالانتجن، إذا كان هناك اي signal + +56 +00:04:20,530 --> 00:04:23,830 +transduction، فهناك فكتر فانكشن لا يوجد في + +57 +00:04:23,830 --> 00:04:24,050 +الانتجن، + +58 +00:04:30,080 --> 00:04:35,780 +مهم كوربولانت ليه؟ موليكيول هو CD3Z ماشي بجانب ال + +59 +00:04:35,780 --> 00:04:40,740 +TCR هم اللي يلهم الـ cytoplasmic tail ده هو و هم + +60 +00:04:40,740 --> 00:04:45,220 +اللي بيقولوا بالـ signal transduction الحاجة + +61 +00:04:45,220 --> 00:04:50,100 +التانية ال .. ال .. ال antibody في ال constant + +62 +00:04:50,100 --> 00:04:53,900 +region هو ال factor of function ماشي زي ال + +63 +00:04:53,900 --> 00:05:00,030 +complement fixationوهكذا بينما في ال PCR مايلو + +64 +00:05:00,030 --> 00:05:10,050 +ونشوف نشوف أول ايش أول فرق بين التانين تالت PCR + +65 +00:05:10,050 --> 00:05:14,550 +بيبتايد presented by أناسي مليكيول بينما ال PCR + +66 +00:05:14,550 --> 00:05:17,710 +recognize antigen without requirement of + +67 +00:05:17,710 --> 00:05:23,610 +presentation ال recognition is mediated by + +68 +00:05:23,610 --> 00:05:29,170 +variable domain في الجهتينماشى تلقى تلقى تلقى تلقى + +69 +00:05:29,170 --> 00:05:30,330 +تلقى تلقى تلقى تلقى تلقى تلقى تلقى تلقى تلقى تلقى + +70 +00:05:30,330 --> 00:05:30,970 +تلقى تلقى تلقى تلقى تلقى تلقى تلقى تلقى تلقى تلقى + +71 +00:05:30,970 --> 00:05:34,670 +تلقى تلقى تلقى تلقى تلقى تلقى تلقى تلقى تلقى تلقى + +72 +00:05:34,670 --> 00:05:36,370 +تلقى تلقى تلقى تلقى تلقى تلقى تلقى تلقى تلقى تلقى + +73 +00:05:36,370 --> 00:05:42,970 +تلقى تلقى تلقى تلقى تلقى تلقى تلقى تلقى تلقى تلقى + +74 +00:05:42,970 --> 00:05:47,790 +تلقى + +75 +00:05:47,790 --> 00:05:51,950 +ت + +76 +00:05:54,320 --> 00:05:57,820 +لأ انا عبارة عن TCR ايه Alpha One Alpha Two Alpha + +77 +00:05:57,820 --> 00:06:01,500 +Three وده عبارة عن Class One MSC Class One + +78 +00:06:01,500 --> 00:06:06,120 +Molecule ماشي ايه الانتجين يكبر بتاعتك تكتب Alpha + +79 +00:06:06,120 --> 00:06:13,360 +One Alpha Two دمية ال MSC Class One 100% وزي ما + +80 +00:06:13,360 --> 00:06:22,480 +انتوا شايفين TCR مايلو يمسك الا في الانتجن كنت + +81 +00:06:22,480 --> 00:06:27,000 +Alphaالـ Beta-Chain أو الـ TCR تتعامل مع بيبتايد + +82 +00:06:27,000 --> 00:06:31,560 +100% الـ Alpha والبيتا بتاعة الـ TCR تنتهي مرتبط + +83 +00:06:31,560 --> 00:06:39,520 +في الـ TCR الـ + +84 +00:06:39,520 --> 00:06:42,840 +Addition of residue يعني في أطراف خارجية من الـ + +85 +00:06:42,840 --> 00:06:47,600 +TCR هي اللي بترتبط بين الأمسي موليكيول زي ما + +86 +00:06:47,600 --> 00:06:53,210 +شايفين هي الـ TCR مسيك في الانتجنوهي الـ TCR مع + +87 +00:06:53,210 --> 00:06:58,710 +علامة الـ C-molecule طرفيا برضه بيلتقوا و بيمسكوا + +88 +00:06:58,710 --> 00:07:03,930 +الـ Antigen Resonating Cell هي اللي بتقدم الـ + +89 +00:07:03,930 --> 00:07:09,130 +Antigen للـ T Cell خلال ارتباط الـ Antigen بالـ + +90 +00:07:09,130 --> 00:07:12,170 +Measuring Stock Compatibility Complex Class I و + +91 +00:07:12,170 --> 00:07:16,360 +Class II شوفوا إيش اللي بصيرهي عبارة عن antigen + +92 +00:07:16,360 --> 00:07:21,520 +presenting z قدمت الانتجن لمين للتيسل ده هو للتيسل + +93 +00:07:21,520 --> 00:07:28,440 +في الجهتين بس واحدة مقدمة ل cd8 والتانية مقدمة + +94 +00:07:28,440 --> 00:07:34,460 +لمين ل cd4 واتفقنا على اما ال c class واحد هو من + +95 +00:07:34,460 --> 00:07:43,650 +يقدم اللي هوانتجن لـ CD8 تي سايتو توكسيك و بينما + +96 +00:07:43,650 --> 00:07:50,830 +ال Exogenous او MHC class 2 هو من يرتبط بالانتجن + +97 +00:07:50,830 --> 00:07:57,390 +الخارجي و بيقدمه لمين لتيه البرسيل اللي هي CD4 هي + +98 +00:07:57,390 --> 00:08:03,310 +CD8 طبعا في منه في هذه الحالة زي ما انتوا شايفين + +99 +00:08:03,310 --> 00:08:07,400 +ال CD8 بيرتبط في ال MHC مليكيول من براهذا هو بس + +100 +00:08:07,400 --> 00:08:09,880 +بيرتبط في ال constant region مش في ال variable ال + +101 +00:08:09,880 --> 00:08:14,640 +variable ماسك في مين؟ في ال antigen وهي ال CD4 نفس + +102 +00:08:14,640 --> 00:08:21,320 +الحكاية sorry تي antigen are linear molecule in + +103 +00:08:21,320 --> 00:08:29,460 +contrast to MHC both CD4 و CD8 do not interact + +104 +00:08:29,460 --> 00:08:38,360 +with the antigenic peptideشايفين هاي ال TCR وهي ال + +105 +00:08:38,360 --> 00:08:41,980 +MHC موليكول وهي ال Antigen في المصر راهزوا هنا + +106 +00:08:41,980 --> 00:08:48,540 +constant region شايفين اللي هو ال CD4 مسك في مين + +107 +00:08:48,540 --> 00:08:56,430 +ال constant region او مين of MHC موليكولCD4 وCD8 + +108 +00:08:56,430 --> 00:08:59,490 +تتعامل مع الـ invariant اللي هي constant residue + +109 +00:08:59,490 --> 00:09:05,850 +of MSC class 1 و2 والتالي ال specificity of + +110 +00:09:05,850 --> 00:09:11,010 +response اللي مسئول عنها مش ال antigen وانما اللي + +111 +00:09:11,010 --> 00:09:14,010 +مسئول عنها هو ال nature of antigen presenting cell + +112 +00:09:14,010 --> 00:09:22,550 +من يقنطم ال antigen كيف يصير يا سيد العزيز؟بنعمل + +113 +00:09:22,550 --> 00:09:33,270 +اختلاف خصيص بين الانتجن + +114 +00:09:33,270 --> 00:09:41,470 +وانتجن الانتجن وانتجن + +115 +00:09:41,470 --> 00:09:48,290 +الانتجن وانتجن + +116 +00:09:48,290 --> 00:09:49,030 +الانتجن وانتجن الانتجن وانتجن الانتجن وانتجن + +117 +00:09:49,030 --> 00:09:49,030 +الانتجن وانتجن الانتجن وانتجن الانتجن وانتجن + +118 +00:09:49,030 --> 00:09:49,030 +الانتجن وانتجن الانتجن وانتجن الانتجن وانتجن + +119 +00:09:49,030 --> 00:09:50,030 +الانتجن وانتجن الانتجن وانتجن الانتجن وانتجن + +120 +00:09:50,030 --> 00:09:50,030 +الانتجن وانتجن الانتجن وانتجن الانتجن وانتجن + +121 +00:09:50,030 --> 00:09:50,090 +الانتجن وانتجن الانتجن وانتجن الانتجن وانتجن ال + +122 +00:09:51,050 --> 00:09:59,110 +واحدة بتعمل phagocytosis والتانية by endocytosis + +123 +00:09:59,110 --> 00:10:02,830 +وهم + +124 +00:10:02,830 --> 00:10:10,000 +بيخش ال antigen على داخل الخليةبنعمله processing و + +125 +00:10:10,000 --> 00:10:15,940 +بيطلع مرتبط على سطح الخلية بواسطة اللي هو ال MSC + +126 +00:10:15,940 --> 00:10:21,600 +molecule class two molecule both have class two + +127 +00:10:22,150 --> 00:10:26,050 +مهشي موليكيول اللي على سطح طبعا بتقدم الانتجين في + +128 +00:10:26,050 --> 00:10:29,810 +هذه الحالة اللتي هي البرسيل اللي هي CD4 فده هي + +129 +00:10:29,810 --> 00:10:35,690 +both ماشي RCD4 طبعا بعدين بيصير فيه cytokine + +130 +00:10:35,690 --> 00:10:41,880 +release متمرطبطالجهتين و ال telephosize بتساعد ال + +131 +00:10:41,880 --> 00:10:45,660 +macro phage تعمل نشط ال macro phage و أثناء + +132 +00:10:45,660 --> 00:10:52,540 +تنشيطها كمان بتعمل destruction ل ال phagocytosed + +133 +00:10:52,540 --> 00:10:57,800 +يعني بتنشط ال macro phage to phagocytosedلـ + +134 +00:10:57,800 --> 00:11:02,980 +Microbe and Kill it ونفس الحكاية تساعد نشط + +135 +00:11:02,980 --> 00:11:06,900 +البيلينفوسايت وبالتالي بتطلع ان Antibody هذا هو + +136 +00:11:06,900 --> 00:11:14,660 +which can fix the antigen and destroy it بينما ال + +137 +00:11:14,660 --> 00:11:19,380 +MSC Class I Molecule هذا هو موجود على كل خلايا جسم + +138 +00:11:19,380 --> 00:11:25,420 +الإنسان وهو طبعا بيتعامل مع Endogenous Antigen + +139 +00:11:26,520 --> 00:11:30,060 +هيتولد الـ Antigen في داخل الخلية فبيسلم + +140 +00:11:30,060 --> 00:11:33,920 +processing وبيطلع مرتبط بالـ MSC Class I مليكوري + +141 +00:11:33,920 --> 00:11:38,720 +اللي بيتقدم ل CD8-Cytoplytic أو Cytotoxic + +142 +00:11:38,720 --> 00:11:43,520 +تيليوفوسايت اللي بتعمل Direct Link للـ Target Cell + +143 +00:11:43,520 --> 00:11:51,640 +اللي فيها للمساواة بالـ Antigen الـ + +144 +00:11:51,640 --> 00:11:57,440 +End ResultsC-D4 وC-D8 تجارب تلينفوسية تتعرف على + +145 +00:11:57,440 --> 00:12:04,540 +الانتجين على مكان ثلاث مصادر تبعًا مجتمعًا لجميع + +146 +00:12:04,540 --> 00:12:09,720 +الانتجين كما تشاهدون + +147 +00:12:09,720 --> 00:12:16,740 +يوم التلينفوسية تتعرف على الانتجين التجارب الوحيدة + +148 +00:12:16,740 --> 00:12:24,440 +لجميع الانتجينوالتعرف يساعد على CD4 وCD8 100% + +149 +00:12:24,440 --> 00:12:30,100 +بالإضافة إلى ارتباط TCR بالانتجين ياله فيه ان CD4 + +150 +00:12:30,100 --> 00:12:34,520 +وCD8 على سطح الخلايا الانفوسايتز هي من يساعد على + +151 +00:12:34,520 --> 00:12:39,840 +ارتباط TCR بالانتجين ايضا وهو زي ما سمينا كو + +152 +00:12:39,840 --> 00:12:42,980 +ريسبتور بيتبت بال invariant invariant and constant + +153 +00:12:42,980 --> 00:12:46,520 +region of mean of MHC class 2 molecule + +154 +00:12:49,630 --> 00:12:54,250 +دعونا نشاهد خصائص TCR Mediated Antigen Recognition + +155 +00:12:54,250 --> 00:12:58,810 +كما تشاهدون عملية + +156 +00:12:58,810 --> 00:13:01,610 +التعرف على الانتجن من خلال ارتباطه بالـ MSC + +157 +00:13:01,610 --> 00:13:09,310 +مليكيول على سطح الخلية وكل كلون محدد + +158 +00:13:09,310 --> 00:13:11,730 +فقط لأنتجن واحد + +159 +00:13:15,540 --> 00:13:18,820 +والـ Antigen recognition is mediated by a specific + +160 +00:13:18,820 --> 00:13:24,320 +domain of TCR طبيعي جدا اللي هو Variable Domain + +161 +00:13:24,320 --> 00:13:29,300 +Variable Region of Alpha Beta اللي هي اللي بتتعرف + +162 +00:13:29,300 --> 00:13:38,960 +على الانتجن وSignaling is induced by CD3Zeta اللي + +163 +00:13:38,960 --> 00:13:42,920 +associated non-covalently بالTCR + +164 +00:13:46,630 --> 00:13:50,270 +TCR طبعا روتين on different T lymphocyte arise + +165 +00:13:50,270 --> 00:13:53,410 +from gene rearrangement اتفقنا ما ينطبق على ال T + +166 +00:13:53,410 --> 00:13:58,170 +lymphocyte او ال PCR ينطبق على ال TCR في عندنا + +167 +00:13:58,170 --> 00:14:02,670 +توابلي بيبتعد Alpha و Beta Alpha خلّينا نشبهها بال + +168 +00:14:02,670 --> 00:14:05,950 +lighted chain تبع ال Minoglobulin و Beta هي ال + +169 +00:14:05,950 --> 00:14:09,330 +heavy chain فطبعا في ال lighted chain في عندنا two + +170 +00:14:09,330 --> 00:14:12,250 +gene segment هي ال variable و ال joining مرتبط + +171 +00:14:12,250 --> 00:14:16,780 +بمينبالـ Constant Gene بسله بعدين Rearrangement + +172 +00:14:16,780 --> 00:14:24,260 +برضه مرتبط بإيش بالـ Constant Gene ماشي ال هنا + +173 +00:14:24,260 --> 00:14:30,940 +Variable Joining مرتبط في مين؟ في Constant إيش؟ + +174 +00:14:30,940 --> 00:14:37,920 +Constant Gene طبعا بالمقابل ال Beta ده هيفيها + +175 +00:14:37,920 --> 00:14:41,520 +تلاتة genes segment الـ variable و ال diversity هي + +176 +00:14:41,520 --> 00:14:46,620 +واحد و اتنين ثم ال joining ماشي و مرتبطين ب + +177 +00:14:46,620 --> 00:14:52,060 +constant a,b,c,d gene لكن واحد اتنين they are the + +178 +00:14:52,060 --> 00:14:56,660 +same ايه و بعدين بيصير في rearrangement صار في عند + +179 +00:14:56,660 --> 00:15:01,320 +ال rearrangement ل ال beta وصار rearrangement ل ال + +180 +00:15:01,320 --> 00:15:04,920 +alpha اتنين طبعا بيصير الحماشtranscription + +181 +00:15:04,920 --> 00:15:11,820 +وtranslation ويكونوني الـ TCR as alpha beta اللي + +182 +00:15:11,820 --> 00:15:18,440 +هو polypeptide chain بيصير فيه allylic exclusion + +183 +00:15:18,440 --> 00:15:23,760 +زي ما صار في مين في ال PCR بمعنى انه each + +184 +00:15:23,760 --> 00:15:31,680 +individual بياخد من الأم او من الأب alpha chain + +185 +00:15:31,680 --> 00:15:39,450 +gene100% وهو طبعا عملية ال recombination بتتم من + +186 +00:15:39,450 --> 00:15:46,030 +خلال ارتباط ال variable بال joining عشان يكونوا + +187 +00:15:46,030 --> 00:15:52,330 +Alpha في ال maternal او لو مش كون ال maternal + +188 +00:15:52,330 --> 00:15:59,370 +عملية الارتباط productive ماشي خلاص ال + +189 +00:15:59,370 --> 00:16:03,500 +recombinationاللي موجود على ال paternal بيسمله + +190 +00:16:03,500 --> 00:16:08,740 +shut off وضل هذا شغال إذا صار نانو productive فان + +191 +00:16:08,740 --> 00:16:13,540 +بيصير ناخد من ال paternal يبقى وان ال chromosome + +192 +00:16:13,540 --> 00:16:17,400 +is only used وإن كان من ال maternal أو ال paternal + +193 +00:16:17,400 --> 00:16:20,900 +this will prevent individual cell from expressing + +194 +00:16:20,900 --> 00:16:26,900 +more than one TCR أكتر من TCR ماشي هذا هو مواد + +195 +00:16:26,900 --> 00:16:30,700 +الكلام شوفنا في إيش في ال PCR + +196 +00:16:32,150 --> 00:16:36,510 +طيب قصة ال TCR rearrangement اللي بيصير في ال + +197 +00:16:36,510 --> 00:16:43,430 +Thymus احنا اتفقنا انه هي الخلايا ال T cell في + +198 +00:16:43,430 --> 00:16:48,030 +مراحل مبكرة جدا اللي هو Progenitor Thymocytes + +199 +00:16:48,030 --> 00:16:53,590 +بيسموها بتنتقل إلى مين إلى الغدة اللي هي Thymus + +200 +00:16:53,590 --> 00:16:57,210 +اللي هي منطقة فوق الجنب فوق + +201 +00:17:04,410 --> 00:17:09,790 +وTCL تتحرك من بولمار وتجه الـ Thymus في الـ Thymus + +202 +00:17:09,790 --> 00:17:18,390 +هناك مثلها اللي هو Rearrangement للـ TCR و اللي + +203 +00:17:18,390 --> 00:17:23,450 +بعد هي كذا طبعا تنضج الخلية و تطلع من الـ Thymus و + +204 +00:17:23,450 --> 00:17:26,870 +تطلع الـ Peripheral Blood ثم Secondary Lymphoid + +205 +00:17:26,870 --> 00:17:33,350 +Organ looking for Antigenماذا يحدث في هذه العملية؟ + +206 +00:17:33,350 --> 00:17:39,550 +يحدث نيجاتيب و Positive Selection ببساطة نحكي + +207 +00:17:39,550 --> 00:17:42,790 +العملية ببساطة ال positive selection انه في بداية + +208 +00:17:42,790 --> 00:17:50,750 +القمر ال T cell بيتقدم لها ال MSC molecule + +209 +00:17:54,000 --> 00:17:58,060 +بتتعرف عليه اللي بترتبط فيه إذا تعرفت عليه ورتبطت + +210 +00:17:58,060 --> 00:18:01,420 +فيه بتعيش زي ما اتعرفت عليه طول ضائب اياه موتوشيز + +211 +00:18:01,420 --> 00:18:06,020 +وسموا هذه العملية positive selection and it's + +212 +00:18:06,020 --> 00:18:11,240 +usually ال ال + +213 +00:18:11,240 --> 00:18:14,680 +telophosite اللي بتضل هي أبدا تيلوفوسيات الفاعلة + +214 +00:18:14,680 --> 00:18:17,800 +التي لا تتعرف علينا زي ما عمنا نشوفه على self + +215 +00:18:17,800 --> 00:18:23,760 +antigen زي ما انتوا شايفين هي TCRماشي تقدمي لها + +216 +00:18:23,760 --> 00:18:29,640 +الانتيجين اللي هو ال MSC موليكيول مرتبط ببيبتاين + +217 +00:18:29,640 --> 00:18:34,880 +تتعرف عليه ال T lymphocytes و بترتبط فيه و اذا + +218 +00:18:34,880 --> 00:18:42,800 +رتبطت it will ASP survive و نسمي هذه العملية + +219 +00:18:42,800 --> 00:18:47,060 +positive selection وبالتالي ال positive selection + +220 +00:18:47,060 --> 00:18:51,630 +ensure that T cell is capableof interacting with + +221 +00:18:51,630 --> 00:18:59,410 +peptide MHC complex ماشي it will remain alive and + +222 +00:18:59,410 --> 00:19:05,290 +it will recognize it in the future ماشي طبعا هذا + +223 +00:19:05,290 --> 00:19:10,310 +بتقدم ل CD4 او + +224 +00:19:10,310 --> 00:19:14,270 +CD8 CD4 + +225 +00:19:14,270 --> 00:19:22,220 +developed in the basis of the abilityأو TCR تتعامل + +226 +00:19:22,220 --> 00:19:26,100 +مع MSC Class 2 بشكل طبيعي جدا قدرته على ارتباط + +227 +00:19:26,100 --> 00:19:30,240 +طبعا + +228 +00:19:30,240 --> 00:19:37,380 +TCR طبعا اللي T + +229 +00:19:37,380 --> 00:19:42,460 +Cell ارتبطت بال Class 1 Peptidereserve expression + +230 +00:19:42,460 --> 00:19:48,480 +of CD8 وبتفقد منه CD4 يعني اللي مسكت اللي شغلت ال + +231 +00:19:48,480 --> 00:19:51,060 +MSC class 1 هذا هي + +232 +00:19:57,820 --> 00:20:03,000 +يعني بيبقى على سطحها اللي هو CD8 و بتفقد ال CD4 و + +233 +00:20:03,000 --> 00:20:09,380 +العكس طبعا ليه؟ ارتبطت بال MSC Class 2 ماشي بتحتفظ + +234 +00:20:09,380 --> 00:20:17,840 +بال CD4 و تفقد منه ال CD8 تاني ال CD8 بي develop + +235 +00:20:17,840 --> 00:20:21,120 +on the ability of TCR to interact with MSC Class 1 + +236 +00:20:21,120 --> 00:20:21,640 +ماشي + +237 +00:20:26,220 --> 00:20:29,720 +طبعا تي سي ار اللي دونات ريكنيز عمل سي موليكيول + +238 +00:20:29,720 --> 00:20:33,400 +تول دايب ايام اكتروسيز وسموه failure of positive + +239 +00:20:33,400 --> 00:20:41,300 +selection طبعا هذا ال type of selection to weed + +240 +00:20:41,300 --> 00:20:47,500 +out a TCR that cannot + +241 +00:20:51,010 --> 00:20:55,410 +or incapable of detecting msc class one or msc + +242 +00:20:55,410 --> 00:21:05,870 +antigen complex negative + +243 +00:21:05,870 --> 00:21:11,990 +selection طبعا بعد هي تنزل deep في المنطقة تارطبات + +244 +00:21:11,990 --> 00:21:16,660 +ال cortex بالمضالة وهناك برضه بتقدم لهاالـ Antigen + +245 +00:21:16,660 --> 00:21:21,820 +مرة تانية لما شي موليكيول مرتبط بفرن بـ Self + +246 +00:21:21,820 --> 00:21:26,260 +-antigen وطبعا الخلايا التي تتعرف عليها أو تتطبط + +247 +00:21:26,260 --> 00:21:29,960 +فيها it will die by apoptosis انما الخلايا التي لا + +248 +00:21:29,960 --> 00:21:34,000 +تتطبط فيها أو تتعرف عليها it will survive لأنه + +249 +00:21:34,000 --> 00:21:37,940 +مطلوب منها في هذه المرحلة انها تتعرف على الـ Self + +250 +00:21:37,940 --> 00:21:42,100 +-antigen ولا تتفاعل معاه ويسمو هذه الخطوة Self-non + +251 +00:21:42,100 --> 00:21:43,100 +-self discrimination + +252 +00:21:55,890 --> 00:22:02,670 +الجسم يقوم بإزالة خلية + +253 +00:22:02,670 --> 00:22:08,190 +من الانفوسايتات + +254 +00:22:08,190 --> 00:22:11,880 +بشكل اكتر بشكل اكترطبعا الـ Thymocyte maturation + +255 +00:22:11,880 --> 00:22:20,000 +مشير في مراتين مختلفة وهذا عبارة عن رابط من وجود + +256 +00:22:20,000 --> 00:22:25,600 +في مراتين مختلفة ليش + +257 +00:22:25,600 --> 00:22:29,660 +العملية يعني شو محصلتها قالوا positive selection + +258 +00:22:29,660 --> 00:22:37,480 +بعمل MRC restrictionلكن ليش؟ هذا بيؤدى ويؤكد على + +259 +00:22:37,480 --> 00:22:40,780 +ان الـ CD8-T-Lymphocyte is specific for MSC Class + +260 +00:22:40,780 --> 00:22:44,160 +I وان الـ CD4-T-Lymphocyte is specific only for + +261 +00:22:44,160 --> 00:22:49,260 +MSC Class II بيبتاية الكمبليكس negative selection + +262 +00:22:49,260 --> 00:22:54,600 +remove self-reactive اللي شو بيصير بعد هيك؟ كانوا + +263 +00:22:54,600 --> 00:22:58,180 +الـ T-Lymphocyte migrate من الـ Thyme تطلع من الـ + +264 +00:22:58,180 --> 00:23:02,200 +Thyme على البريفرالينفويد organs و looking for + +265 +00:23:02,200 --> 00:23:08,490 +أيش؟بحث عن الـ Antigen اللي مرتبط باما class 1 او + +266 +00:23:08,490 --> 00:23:13,750 +اما class 2 وبعد ذلك بيصبح لها Clonally Expanded + +267 +00:23:13,750 --> 00:23:17,350 +هل + +268 +00:23:17,350 --> 00:23:20,350 +هو ال Antigen presentation كل هذا ولا خلاص فيه اشي + +269 +00:23:20,350 --> 00:23:27,560 +تاني طبعا قالوا لأعملية ال activation بيصير فيها + +270 +00:23:27,560 --> 00:23:30,860 +اشي تاني زي ما انتوا شايفين تحتاج الى two signal + +271 +00:23:30,860 --> 00:23:36,140 +الأولاني هو الاشي بتقدم ال antigen على سطح ال + +272 +00:23:36,140 --> 00:23:39,240 +مرتبط الأمسي مليكيول على سطح ال antigen presenting + +273 +00:23:39,240 --> 00:23:45,240 +cell one مثال على class two وهي ال antigen وهي ال + +274 +00:23:45,240 --> 00:23:49,040 +telemphosites ماشي ثم CD4 + +275 +00:23:56,350 --> 00:24:04,830 +ماشي طبعا ال CD4 مرتبط + +276 +00:24:04,830 --> 00:24:08,630 +في ال constant region of MSC class 2 بس مش واضحة + +277 +00:24:08,630 --> 00:24:12,550 +في الصورة هنا لكن هنا عايش اللي واضح انه we need + +278 +00:24:12,550 --> 00:24:15,590 +second signal we need second signal وهي ال second + +279 +00:24:15,590 --> 00:24:19,670 +signal تكونات ده هو ال cost stimulation يبقى الأول + +280 +00:24:19,670 --> 00:24:23,440 +ان هي الارتباط بال أنتجل التاني عايشالذي هو الـ + +281 +00:24:23,440 --> 00:24:26,640 +Second Signal وهي برضه الـ Co-stimulatory reaction + +282 +00:24:26,640 --> 00:24:35,720 +CD28-V7 1 أو 2 ماشي يتم الارتباط ويقوي الرابطة في + +283 +00:24:35,720 --> 00:24:41,120 +هذه الحالة هذه Co-stimulatory reaction هذا هي + +284 +00:24:41,120 --> 00:24:44,420 +listing antigen presenting cell to not express Co + +285 +00:24:44,420 --> 00:24:49,680 +-stimulation طبيعي جدا أي خلية جاعدة ما بتعمل ما + +286 +00:24:49,680 --> 00:24:50,980 +بتكون Co-stimulators + +287 +00:24:53,320 --> 00:25:02,260 +حتى وإن كانت مرتبطة بمين ب بيبتايد أنتيجن نهير + +288 +00:25:02,260 --> 00:25:05,060 +T cell that encounter antigen in the absence of + +289 +00:25:05,060 --> 00:25:08,920 +costimulator become anergic غياب ال costimulatory + +290 +00:25:08,920 --> 00:25:14,440 +bonding بيعمل بيخلق الخلية مشلولة anergic cell + +291 +00:25:14,440 --> 00:25:20,680 +يعني مشلولة لاتت نشط انما اللي يحصل فيه نشاط فده + +292 +00:25:20,680 --> 00:25:27,180 +هوهذا هي يوم يكون فيه ارتباط يوم يكون فيه foreign + +293 +00:25:27,180 --> 00:25:33,340 +antigen يصير الارتباط الأولاني ماشي مع ال TCR ثم + +294 +00:25:33,340 --> 00:25:39,800 +CD28 مع ال B7 ثم يصير فيه release to cytokine ماشي + +295 +00:25:39,800 --> 00:25:43,160 +تتنشط اللي هو T lymphocytes اللي بتفرد ال cytokine + +296 +00:25:43,160 --> 00:25:48,520 +ومن نشط الخلق ال cytokine اللي طالع هو هنا في هذا + +297 +00:25:48,520 --> 00:25:52,060 +الحالة IL-12 عشان ينشط يعني جاي من Macrophage + +298 +00:25:53,430 --> 00:25:58,730 +الخلايا الموجودة على سطح + +299 +00:25:58,730 --> 00:26:05,970 +التيلينفوسايت ويزودونها بشكل ثانوي لإكتماع + +300 +00:26:05,970 --> 00:26:07,950 +تلينفوسايت ومتما يحصل اكتماع تلينفوسايت يحصل + +301 +00:26:07,950 --> 00:26:12,290 +اكتماع تلينفوسايت ومتما يحصل اكتماع تلينفوسايت + +302 +00:26:12,290 --> 00:26:14,850 +يحصل + +303 +00:26:16,460 --> 00:26:19,600 +ليس فقط فرصة واحدة فرصة واحدة فرصة واحدة فرصة + +304 +00:26:19,600 --> 00:26:32,340 +واحدة فرصة واحدة فرصة واحدة + +305 +00:26:32,340 --> 00:26:41,900 +فرصة + +306 +00:26:41,900 --> 00:26:45,560 +واحدة + +307 +00:26:46,330 --> 00:26:52,010 +لا توجد إجابة أو إفعالية أو إفعالية حتى إذا كانت + +308 +00:26:52,010 --> 00:26:54,230 +موجودة في مستوى التواصل الانتجيني الذي يمكنه إعطاء + +309 +00:26:54,230 --> 00:27:01,210 +الثانوية إشارة لا يمكن تفعيلها إذا كانت موجودة + +310 +00:27:01,210 --> 00:27:01,230 +في مستوى التواصل الانتجيني الذي يمكن تفعيلها إذا + +311 +00:27:01,230 --> 00:27:01,970 +كانت موجودة في مستوى التواصل الانتجيني الذي يمكن + +312 +00:27:01,970 --> 00:27:03,310 +تفعيلها إذا كانت موجودة في مستوى التواصل الانتجيني + +313 +00:27:03,310 --> 00:27:06,750 +الذي يمكن تفعيلها إذا كانت موجودة في مستوى التواصل + +314 +00:27:06,750 --> 00:27:10,510 +الانتجيني الذي يمكن تفعيلها إذا كانت موجودة في + +315 +00:27:10,510 --> 00:27:13,130 +مستوى التواصل الانتتحفز وان الانتجن الـ T-cell + +316 +00:27:13,130 --> 00:27:14,210 +انتجن الـ T-cell انتجن الـ T-cell انتجن الـ T-cell + +317 +00:27:14,210 --> 00:27:14,930 +انتجن الـ T-cell انتجن الـ T-cell انتجن الـ T-cell + +318 +00:27:14,930 --> 00:27:17,030 +انتجن الـ T-cell انتجن الـ T-cell انتجن الـ T-cell + +319 +00:27:17,030 --> 00:27:21,490 +انتجن الـ T-cell انتجن الـ T-cell انتجن الـ T-cell + +320 +00:27:21,490 --> 00:27:23,790 +انتجن الـ T-cell انتجن الـ T-cell انتجن الـ T-cell + +321 +00:27:23,790 --> 00:27:23,790 +انتجن الـ T-cell انتجن الـ T-cell انتجن الـ T-cell + +322 +00:27:23,790 --> 00:27:23,790 +انتجن الـ T-cell انتجن الـ T-cell انتجن الـ T-cell + +323 +00:27:23,790 --> 00:27:27,420 +انتجن الـ T-cell انتجن الـ T-cell انسلحة مسكت فيه + +324 +00:27:27,420 --> 00:27:33,160 +ماشي هرتبطت و بيصير simultaneous detection of + +325 +00:27:33,160 --> 00:27:36,000 +foreign antigen and second signal activity cell + +326 +00:27:36,000 --> 00:27:40,420 +and drive subsequent immune response يقبل تمسك في + +327 +00:27:40,420 --> 00:27:44,680 +سلفة انتجين هدا هي مسكت في سلفة انتجين بس انها هي + +328 +00:27:44,680 --> 00:27:50,130 +ايش tolerance او deletion or allergyهذا الكلام + +329 +00:27:50,130 --> 00:27:58,250 +مصير في ايه؟ في اللي هو ال second .. + +330 +00:27:58,250 --> 00:28:01,110 +في غياب ال second signal resting antigen + +331 +00:28:01,110 --> 00:28:03,530 +presenting cell express little or no cost + +332 +00:28:03,530 --> 00:28:09,530 +stimulation and display self-antigenوبالتالي + +333 +00:28:09,530 --> 00:28:12,830 +مرتبطة بتكون الـ self-antigen وبالتالي لا تنشد T + +334 +00:28:12,830 --> 00:28:15,690 +-Lymphocytes as a result T-Lymphocytes become + +335 +00:28:15,690 --> 00:28:19,230 +energetic and there is no longer capable of + +336 +00:28:19,230 --> 00:28:21,750 +mediating immune response مافي إمكانية تعملنا + +337 +00:28:21,750 --> 00:28:25,610 +immune response thus energy serve as an important + +338 +00:28:25,610 --> 00:28:30,710 +safeguard هي مرحلة بوابة أمان ماشية against + +339 +00:28:30,710 --> 00:28:36,110 +autoimmunity in the peripheryطبعا هنا زي ما انتوا + +340 +00:28:36,110 --> 00:28:39,970 +شايفين الـ two signal لازمين are required to + +341 +00:28:39,970 --> 00:28:44,770 +activate T cell but only one for the activated + +342 +00:28:44,770 --> 00:28:49,630 +match was cell to function يعني لخلية نايف بدنا + +343 +00:28:49,630 --> 00:28:55,070 +two signal للمatch و one signal is enoughماشي هي + +344 +00:28:55,070 --> 00:28:58,930 +عبارة عن mature signal واحدة صار في ايش الارتباط + +345 +00:28:58,930 --> 00:29:03,950 +ايه فصار في الهو direct killing mature direct + +346 +00:29:03,950 --> 00:29:08,450 +killing هنا لكن هي نايف نايف نايف نايف نايف نايف + +347 +00:29:08,450 --> 00:29:08,930 +نايف نايف نايف نايف نايف نايف نايف نايف نايف نايف + +348 +00:29:08,930 --> 00:29:12,330 +نايف + +349 +00:29:12,330 --> 00:29:14,470 +نايف نايف نايف نايف نايف نايف نايف نايف نايف نايف + +350 +00:29:14,470 --> 00:29:20,330 +نايف نايف نايف نايف نايف نايف نايف نايف نايف نايف + +351 +00:29:20,330 --> 00:29:20,570 +نايف نايف نايف نايف نايف نايف نايف نايف نايف نايف + +352 +00:29:20,570 --> 00:29:20,610 +نايف نايف نايف نايف نايف نايف نايف نايف نايف نايف + +353 +00:29:20,610 --> 00:29:29,150 +نايف نايف نايف نأرجو أن تكونوا قد أفدتم لها بإذن + +354 +00:29:29,150 --> 00:29:29,390 +الله + diff --git a/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/_Zm74aS0kIU_postprocess.srt b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/_Zm74aS0kIU_postprocess.srt new file mode 100644 index 0000000000000000000000000000000000000000..53613b57a1bce8741c130bb0585df60886c62eb3 --- /dev/null +++ b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/_Zm74aS0kIU_postprocess.srt @@ -0,0 +1,1660 @@ +1 +00:00:02,430 --> 00:00:05,830 +بسم الله الرحمن الرحيم و بيه نستعين و عليه نتوكل + +2 +00:00:05,830 --> 00:00:12,810 +أجمعين كنا قد صنفنا المناعة الى innate و acquired + +3 +00:00:12,810 --> 00:00:19,470 +immunity في محاضرة سابقة و اليوم ان شاء الله هناخد + +4 +00:00:19,470 --> 00:00:26,750 +أنثى على ال innate immunity في محاضرتين ثم نتطلق + +5 +00:00:26,750 --> 00:00:29,690 +الى ال acquired immunity بتفاصيلتها المختلفة + +6 +00:00:34,650 --> 00:00:41,290 +فاتعرفنا أيضا على أدواتها المختلفة ومن أدواتها انه + +7 +00:00:41,290 --> 00:00:45,310 +الان + +8 +00:00:45,310 --> 00:00:50,990 +هنصنفهم الهيومرال وcellular ويدعونا لنا السابق + +9 +00:00:50,990 --> 00:00:53,970 +الأحداث فلنبدأ على بركة الله + +10 +00:00:59,770 --> 00:01:05,830 +طبعا كنا بنعرف انه .. ايضا في مقدمة المرة اللى + +11 +00:01:05,830 --> 00:01:11,590 +فاتت انه ال .. كل خلايا الجسم تلعب دور كبير في + +12 +00:01:11,590 --> 00:01:15,150 +مناعة الجسم و ايضا قسمنا ال .. + +13 +00:01:18,210 --> 00:01:23,890 +وخلايا تعمل في ال acquired immunity وقلنا ان ال + +14 +00:01:23,890 --> 00:01:28,050 +innate immunity كل الخلايا معاد ال lymphocytes + +15 +00:01:28,050 --> 00:01:33,530 +تلعب دور كبير في ال innate immunity وان ال + +16 +00:01:33,530 --> 00:01:36,670 +acquired immunity ال major cells فيها هي ال + +17 +00:01:36,670 --> 00:01:40,990 +lymphocyte بنوعها ال B وT lymphocyte ولاحقا ننسى + +18 +00:01:40,990 --> 00:01:46,060 +ان في collaboration between these cellsهذا طبعا + +19 +00:01:46,060 --> 00:01:51,240 +الـ Hemopoietic Tree للتذكير عشان نتعرف على مصادر + +20 +00:01:51,240 --> 00:01:58,160 +هذه الخلايا اللي جاية أصلا من البونمانو Myl + +21 +00:01:58,160 --> 00:02:02,780 +-T cell قسمها طبعا زي ما اتفقنا إلى Myloid + +22 +00:02:02,780 --> 00:02:07,600 +وLymphoid واتفقنا على أن Myloid هي عبارة عن + +23 +00:02:07,600 --> 00:02:11,910 +Granulocytic وMonocyticالـ Granulocyte نعرفها هي + +24 +00:02:11,910 --> 00:02:16,410 +نيتروفيل وبيزوفيل وإيزوفريل بينما الـ monocytic + +25 +00:02:16,410 --> 00:02:22,330 +تتحول إلى ال macrophage بأنواعها منها Langerhans + +26 +00:02:22,330 --> 00:02:27,090 +وكفارف وDendritic cell بينما ال lymphoid فهي T + +27 +00:02:27,090 --> 00:02:30,850 +cell وB cellو الـ T cell ان شاء الله هتتطرخ + +28 +00:02:30,850 --> 00:02:36,670 +لأنواعها أشهر أنواعها هي البرسيل و هي ال cytotoxic + +29 +00:02:36,670 --> 00:02:42,030 +T cell و ال suppressor و في نوعه كمان مهم هو + +30 +00:02:42,030 --> 00:02:47,290 +delayed type hypersensitivity أما ال B lymphocyte + +31 +00:02:47,290 --> 00:02:53,390 +فبتتحول إلى plasma cell اللي بتدينها ال antibody و + +32 +00:02:53,390 --> 00:02:56,790 +هي الdendritic cell أنا مصنفينها على أنها هي ال + +33 +00:02:56,790 --> 00:03:01,150 +lymphoidوإن كان لغاية الآن احنا ما بنعرف المصدر + +34 +00:03:01,150 --> 00:03:07,770 +الأساسي تبعها هل هي ال infoid ولا myeloid قسموا ال + +35 +00:03:07,770 --> 00:03:13,140 +immune system إلى زي ما قلنا لكم وينnon-specific + +36 +00:03:13,140 --> 00:03:17,660 +اللي مقصود فيها innate immunity وspecific اللي + +37 +00:03:17,660 --> 00:03:22,280 +مقصود فيها acquired immunity وكل واحدة منهم قسموها + +38 +00:03:22,280 --> 00:03:28,860 +إلى نوعين non-specific humoral وcellular وspecific + +39 +00:03:28,860 --> 00:03:33,440 +أيضا humoral وcellular في ال non-specific ال + +40 +00:03:33,440 --> 00:03:37,620 +humoralيتمثل بالـ complement بالـ interferon بـ + +41 +00:03:37,620 --> 00:03:42,600 +tumors نكروسيز فاكتور وفي مجموعة كبيرة من ال + +42 +00:03:42,600 --> 00:03:48,360 +secreted protein أيضا بتندرج تحت هذه القائمة بينما + +43 +00:03:48,360 --> 00:03:52,240 +ال cellular هي ال phagocytic cell و ال phagocytic + +44 +00:03:52,240 --> 00:03:55,760 +أشهر ال phagocytic cell هي او ال professional + +45 +00:03:55,760 --> 00:03:59,800 +بيسموها phagocytic cell هي ال macrophage و ال + +46 +00:03:59,800 --> 00:04:07,450 +neutrophil بينما ال specificأيضًا قسموها لقسمين، + +47 +00:04:07,450 --> 00:04:10,330 +اللي هي Umrah لـ Cellular اللي هي Umrah المتمثلة + +48 +00:04:10,330 --> 00:04:14,450 +بالـ B-Lymphocytes ودورها في إنتاج الـ Antibody + +49 +00:04:14,450 --> 00:04:18,730 +بينما Cellular متمثلة بالـ Cell Mediated Immunity + +50 +00:04:18,730 --> 00:04:25,170 +و اللي بتقوم فيها الـ T Cell و Other Effector Cell + +51 +00:04:25,170 --> 00:04:28,770 +قبل + +52 +00:04:28,770 --> 00:04:30,690 +ما نبدأ في ال .. + +53 +00:04:33,710 --> 00:04:45,810 +التفصيلات هذه دي دي دي دي + +54 +00:04:45,810 --> 00:04:46,090 +دي دي دي دي دي دي دي دي دي دي دي دي دي دي دي دي دي + +55 +00:04:46,090 --> 00:04:46,390 +دي دي دي دي دي دي دي دي دي دي دي دي دي دي دي دي دي + +56 +00:04:46,390 --> 00:04:46,890 +دي دي دي دي دي دي دي دي دي دي دي دي دي دي دي دي دي + +57 +00:04:46,890 --> 00:04:52,050 +دي دي دي + +58 +00:04:52,050 --> 00:05:02,970 +دي دي دي دي دي دي دي دي دي دي دي دي دي دي دي دي د + +59 +00:05:03,310 --> 00:05:11,690 +بينترج او بيحسن بعدد مرات ال infection في ال + +60 +00:05:11,690 --> 00:05:18,410 +variance of infection شدته لالتهاب على ال immunity + +61 +00:05:18,410 --> 00:05:22,070 +على ال immunity طبعا اي خلل في هذا الميزان هيدي + +62 +00:05:22,070 --> 00:05:28,190 +اما الى الحالة المرضية وهو الحالة + +63 +00:05:38,880 --> 00:05:42,320 +Infection كالقاتي انه لما الإنسان يتعرض إلى + +64 +00:05:42,320 --> 00:05:49,100 +infection تتصدى له ال innate immunity و بما إنها + +65 +00:05:49,100 --> 00:05:53,240 +هي ال first line defense mechanism و الأصل إنه إذا + +66 +00:05:53,240 --> 00:05:57,720 +اشتغلت يصير no disease لأنها بتعمل prevention for + +67 +00:05:57,720 --> 00:06:03,280 +infectious agent entry تمنع دخول اللي هو + +68 +00:06:03,280 --> 00:06:05,460 +infectious agent + +69 +00:06:11,500 --> 00:06:16,980 +طبعا اذا مافيش innate immunity او مشتغلتش منيح + +70 +00:06:16,980 --> 00:06:22,860 +انسان بيصير في عنده disease و بعد ال disease + +71 +00:06:22,860 --> 00:06:28,860 +بيكتسب بناعة after recovery و بيصير عنده adaptive + +72 +00:06:28,860 --> 00:06:33,580 +immunity بيصير عنده adaptive immunity و احنا قلنا + +73 +00:06:33,580 --> 00:06:38,940 +ان اصلا ال adaptive immunity بتنتج من خلال تعرض ال + +74 +00:06:38,940 --> 00:06:39,840 +active form + +75 +00:06:44,440 --> 00:06:51,000 +الإنفكشن على ال adaptive immunity upon reinfection + +76 +00:06:51,000 --> 00:06:58,420 +على طول تتصدى للميكروب لأنه أصلا من اسم adaptive + +77 +00:06:58,420 --> 00:07:01,600 +immunity في memory cell بتتعرف على ميكروب و بتتصدى + +78 +00:07:01,600 --> 00:07:05,740 +له مباشرة و تالي there is no disease لكن إذا لا + +79 +00:07:05,740 --> 00:07:11,120 +مافي adaptive immunity ودخل الميكروب نتيجة خلل في + +80 +00:07:11,120 --> 00:07:16,750 +ال innate immunityمعناته المحصلة هي الوفاة لإنسان + +81 +00:07:16,750 --> 00:07:24,710 +بدون مناعة وبالتالي هيموت طيب إيش ال significance + +82 +00:07:24,710 --> 00:07:30,290 +of the immune system قالوا له فوائد متعددة منها ال + +83 +00:07:30,290 --> 00:07:34,350 +protection of invader and eliminating of altered + +84 +00:07:34,350 --> 00:07:39,010 +cell طبيعي جدا الخلايا ال self-reacted cell ال + +85 +00:07:39,010 --> 00:07:45,050 +self-reacted cell أصلا بالجسمبقتلها أول بأول مين + +86 +00:07:45,050 --> 00:07:48,270 +بيقول طبعا بيكب بيقتلها بيقتلها بيادوات منعية + +87 +00:07:48,270 --> 00:07:54,410 +بينما المساوق + +88 +00:07:54,410 --> 00:07:57,590 +تبعت + +89 +00:07:57,590 --> 00:08:00,030 +ال immune response أنا مانديش أقول مساوق خلينا + +90 +00:08:00,030 --> 00:08:02,330 +نقول الأذية اللي بتيجي + +91 +00:08:12,140 --> 00:08:17,280 +inflammationوكلنا عارفين ال inflammatory signs and + +92 +00:08:17,280 --> 00:08:23,780 +symptoms بتتمثل بعدة إيش؟ بعدة صفات من ال redness + +93 +00:08:23,780 --> 00:08:29,640 +و ال hotness و ال pain و طبعا ممكن يصير في loss of + +94 +00:08:29,640 --> 00:08:34,880 +function إذا استمر الموضوع فطبعا هذه بحد ذاتها هي + +95 +00:08:34,880 --> 00:08:42,020 +نوع بتؤثر أو بتسبب أذية و عدم راحة للإنسان + +96 +00:08:43,310 --> 00:08:49,130 +الحاجة التانية أنه ممكن جهاز المناع يخش في مسلك + +97 +00:08:49,130 --> 00:08:55,350 +خاطئ ويسبب اللي هو auto immunity disease نتيجة + +98 +00:08:55,350 --> 00:08:59,170 +مهاجمته for self-antigen + +99 +00:09:08,130 --> 00:09:12,890 +بتشتغل كـ First Line Defense Mechanism بغض النظر + +100 +00:09:12,890 --> 00:09:17,490 +عن نوع الـ Antigen اللي دخل على عكس الـ Adaptive + +101 +00:09:17,490 --> 00:09:24,970 +اللي بتشتغل فقط في وجود الـ Antigen و الـ innate + +102 +00:09:24,970 --> 00:09:28,930 +there is no time lag بمعناه محتاجش إلى incubation + +103 +00:09:28,930 --> 00:09:33,770 +period بينما ال Adaptive محتاج إلى lag period + +104 +00:09:38,660 --> 00:09:52,180 +الانتجينات ليست مخصصة للانتجين لان + +105 +00:09:52,180 --> 00:09:57,980 +لا يوجد ذاكرة نهاروزيكال لكن الانتجينات تعمل ذاكرة + +106 +00:09:57,980 --> 00:10:02,180 +ذاكرة الانتجين + +107 +00:10:04,920 --> 00:10:08,000 +ال component of innate and acquired immunity + +108 +00:10:08,000 --> 00:10:12,340 +قسموها إلى physical barriers وهذه موجودة في ال + +109 +00:10:12,340 --> 00:10:16,400 +innate و متمثلة بال skin و ال gut في الاعي و ال + +110 +00:10:16,400 --> 00:10:21,060 +lung and cilia و ده وقت كثير عرفت اتفصلها قدام + +111 +00:10:21,060 --> 00:10:28,020 +بينما في ال adaptive مافي physical barrierسوليابل + +112 +00:10:28,020 --> 00:10:31,400 +فاكتورز جاله في الانتباد فيه طبعا ماني بروتين ومان + +113 +00:10:31,400 --> 00:10:38,300 +بروتين سيكريشن وحنضرب أنثى لقدام بينما في ال + +114 +00:10:38,300 --> 00:10:46,320 +adaptive ال antibody هو ال form اللي يفرز من ال + +115 +00:10:46,320 --> 00:10:50,360 +adaptive بالنسبال الخلايا في ال innate في عندنا + +116 +00:10:50,360 --> 00:10:51,160 +الفاجوستيكس + +117 +00:10:55,040 --> 00:11:01,700 +زينفيل وال K سل و هنجي ان شاء الله في هذه المحاضرة + +118 +00:11:01,700 --> 00:11:07,400 +هنتطرق لتفصيلات عنها بينما الخلايا في ال adaptive + +119 +00:11:07,400 --> 00:11:11,020 +immunity هي ال T و B lymphocytes + +120 +00:11:15,710 --> 00:11:22,890 +طبعا ال .. ال .. هذه صورة figure ببين لنا على إن + +121 +00:11:22,890 --> 00:11:29,950 +الإنسان physically is a closed system وبالتالي في + +122 +00:11:29,950 --> 00:11:35,130 +physical barrier تمنع دخول أياش any antigen لكن + +123 +00:11:35,130 --> 00:11:41,070 +once this circle is broken من خلال nail من خلال + +124 +00:11:41,070 --> 00:11:48,080 +burns من خلال whateverهيدخل ال microbe و هيكون + +125 +00:11:48,080 --> 00:11:57,500 +بيئة خصبة لنشاط ال anaerobic bacteria طيب ما هي + +126 +00:11:57,500 --> 00:12:01,080 +الأدوات المنعية ال mechanismات المنعية اللي بتتم + +127 +00:12:01,080 --> 00:12:06,140 +في كل نوع من هذه الأنواع خلينا نشوف ال innate و + +128 +00:12:06,140 --> 00:12:09,700 +بعدين نتطرق للأكوان اللي في ال innate احنا اتفقنا + +129 +00:12:09,700 --> 00:12:13,740 +ان في skinو ال skin اللى بلعب دور كبير فى ال skin + +130 +00:12:13,740 --> 00:12:18,680 +squamous cell بتعمل continuous desquamation و فيه + +131 +00:12:18,680 --> 00:12:24,260 +suite بعمل flushing continuous فى غسيل دائم و فيها + +132 +00:12:24,260 --> 00:12:29,560 +fatty acid اللى عبارة عن antibacterial فى ال + +133 +00:12:29,560 --> 00:12:34,060 +gastrointestinal tract فى culinary cells و ال + +134 +00:12:34,060 --> 00:12:38,790 +culinary cells مشهورة بال peristalsismovement اللي + +135 +00:12:38,790 --> 00:12:42,790 +هي الحركات الدودية كمان في low pH في ال stomach + +136 +00:12:42,790 --> 00:12:47,450 +كمان في bile holes في ال gas في ال pancreatic + +137 +00:12:47,450 --> 00:12:51,690 +secretion وفي fatty acids وكل هذه عبارة عن + +138 +00:12:51,690 --> 00:12:56,640 +antibacterial ال lung فيها tracheal cellوالـ + +139 +00:12:56,640 --> 00:13:00,440 +Tracheal cell بتعرفين بتعمل فيها ميوكس سيلياري ب + +140 +00:13:00,440 --> 00:13:08,180 +elevator تعريضة لإيش لأي foreign substance من خلال + +141 +00:13:08,180 --> 00:13:12,220 +الحركة من خلال ال ميوكس اللي موجود فيها + +142 +00:13:12,220 --> 00:13:20,200 +نيزوفيرانكس and I في النوع .. في طبعا في ميوكاس و + +143 +00:13:20,200 --> 00:13:24,810 +في saliva و في tearsوهذه بتعمل continuous flushing + +144 +00:13:24,810 --> 00:13:31,350 +و هي بتحتوي على ال isozymes لبلاد و لينفويد organs + +145 +00:13:31,350 --> 00:13:37,590 +طبعا ال phagocytes أشهرها و هي بتعمل phagocytosis + +146 +00:13:37,590 --> 00:13:39,550 +و intracellular killing + +147 +00:14:00,250 --> 00:14:08,730 +الخلايا الاصابع بانتيجين الاندريكتأو تعتمد على + +148 +00:14:08,730 --> 00:14:16,770 +وجود Antibody-dependent cytolysis أيضًا + +149 +00:14:16,770 --> 00:14:19,350 +من أدوات الـ Innate Immunity الـ Serum قد في + +150 +00:14:19,350 --> 00:14:23,490 +سيراسيفلود فيها الأكتفيرين و الترانسفيرين و هذا + +151 +00:14:23,490 --> 00:14:28,310 +بيعمل Deprevation للعيرون بشخط العيرون فيها + +152 +00:14:28,310 --> 00:14:31,910 +Interferon و هي tumor necrosis factor و هذا مش + +153 +00:14:31,910 --> 00:14:36,770 +تقوله ك Antiviral لبروتينوهي بنشطه الفاجوسيتكسل + +154 +00:14:36,770 --> 00:14:40,070 +فيها الازوزايم وهذه عبارة عن + +155 +00:14:40,070 --> 00:14:43,830 +بيبتايدوكلايكينهيدروليسيز بتقطع روابط الاشهر + +156 +00:14:43,830 --> 00:14:47,970 +لبروتينية ثم فيبرنكتين and complement وطبعا + +157 +00:14:47,970 --> 00:14:51,370 +وظيفتها optionization و enhancement of + +158 +00:14:51,370 --> 00:14:57,470 +phagocytosis وبتعمل inflammation ماهي + +159 +00:14:57,470 --> 00:15:04,160 +أشهر الفاجوسيتكسل طبعا الأن حاجة تتفرق ليهالكن من + +160 +00:15:04,160 --> 00:15:09,100 +المقولات المشهورة عن ال Fagocytic عن أهمية ال + +161 +00:15:09,100 --> 00:15:13,760 +Fagocytes كان Bernard Shaw وهو عبارة عن كاتب + +162 +00:15:13,760 --> 00:15:20,220 +إنجليزي عاش في القرن السادس عشر والسبع عشر قال في + +163 +00:15:20,220 --> 00:15:22,760 +أحد كتاباته أنه + +164 +00:15:26,420 --> 00:15:33,420 +for all diseases في أحمقنا في علاج واحد لكل + +165 +00:15:33,420 --> 00:15:38,360 +الأبراد اللي في الدنيا ايش هو قالوا ت stimulate + +166 +00:15:38,360 --> 00:15:42,380 +phagocyte انك اتنشط ال phagocytes واش بقول عن ال + +167 +00:15:42,380 --> 00:15:48,320 +drugs بقول ال drugs are delusion يعني خرافة انما + +168 +00:15:48,320 --> 00:15:52,860 +when the phagocytes are stimulated they divorce + +169 +00:15:56,090 --> 00:16:02,930 +فاجوسايتز بتخلصنا من إيش من المرض و طبعا زى ما + +170 +00:16:02,930 --> 00:16:07,270 +قلنا الفاجوسيتكسيل الشهرها في أنانوعين + +171 +00:16:07,270 --> 00:16:14,310 +professional و non specific الماكروفيج مهم جدا + +172 +00:16:14,310 --> 00:16:18,790 +تعمل فاجوسيتوسيز لإنترا و extra cellular killing + +173 +00:16:20,660 --> 00:16:23,960 +بتعمل تشيري بير تعمل انتجين presentation for + +174 +00:16:23,960 --> 00:16:26,760 +specific immune response و هتشوف دول عبارة عن + +175 +00:16:26,760 --> 00:16:31,880 +مظائف يعني بالمجمل لكن لها six different function + +176 +00:16:31,880 --> 00:16:37,580 +هنتطرق عليهم في المدام نتعرف عليها ال macro fish + +177 +00:16:37,580 --> 00:16:44,740 +من خلال سلسة surface market وهو CD14 ال neutrophil + +178 +00:16:44,740 --> 00:16:46,620 +أيضا + +179 +00:16:48,130 --> 00:16:54,070 +هي عبارة عن ال other potent immunophagocytic cell + +180 +00:16:54,070 --> 00:16:58,290 +تحتوي على granules سواء كانت ال primary ولا ال + +181 +00:16:58,290 --> 00:17:06,430 +secondary طبعا و tertiary كمان بس أهم شغلتين + +182 +00:17:06,430 --> 00:17:11,630 +بتتميز هي ال primary و ال secondary ال primary + +183 +00:17:11,630 --> 00:17:15,070 +granules جالوا عبارة عن azirophilic granules و + +184 +00:17:15,070 --> 00:17:19,110 +موجودة غالبا في ال young neutrophilبينما الـ + +185 +00:17:19,110 --> 00:17:25,870 +secondary أجرانيال هي أبعاد أجرانيال موجودة في الـ + +186 +00:17:25,870 --> 00:17:31,310 +mature نيوتروفيل ال + +187 +00:17:31,310 --> 00:17:37,570 +primary granules بيها enzymes كثيرة فيها ال + +188 +00:17:37,570 --> 00:17:40,970 +isozyme و ال defensive و ال proteases لكن ما + +189 +00:17:40,970 --> 00:17:45,490 +يميزها وجود ال myroproxidase enzyme بينما ال + +190 +00:17:45,490 --> 00:17:51,240 +secondary أيضا تحتوي علىالليزوزايم تحتوي على اخر + +191 +00:17:51,240 --> 00:17:56,060 +انزايم مهمة + +192 +00:17:56,060 --> 00:17:58,060 +مثل ناد بي اتش اكسيديزي ناد بي اتش اكسيديزي ناد بي + +193 +00:17:58,060 --> 00:17:59,000 +اتش اكسيديزي ناد بي اتش اكسيديزي ناد بي اتش + +194 +00:17:59,000 --> 00:18:01,740 +اكسيديزي ناد بي اتش اكسيديزي ناد بي اتش اكسيديزي + +195 +00:18:01,740 --> 00:18:02,900 +ناد بي اتش اكسيديزي ناد بي اتش اكسيديزي ناد بي اتش + +196 +00:18:02,900 --> 00:18:07,120 +اكسيديزي ناد بي اتش اكسيديزي ناد بي اتش اكسيديزي + +197 +00:18:07,120 --> 00:18:14,860 +ناد بي اتش اكسيديزي ناد بي اتش اكسيديزي ناد بي ات + +198 +00:18:15,300 --> 00:18:24,280 +تتحسس الـ SOS Signal 707 وهذه عبارة عن أدوات + +199 +00:18:24,280 --> 00:18:30,500 +كيميائية بتصل من خلال البكتيريا إفرازات البكتيريا + +200 +00:18:30,500 --> 00:18:37,020 +والخلايا المضامرة مثل الانفرمي الميثيونين مثل وجود + +201 +00:18:37,020 --> 00:18:40,740 +Clotting System Peptide upon infection + +202 +00:18:44,280 --> 00:18:53,760 +كلها هادى بتتولد فى منطقة ال infection و بتهاجر + +203 +00:18:53,760 --> 00:18:56,820 +الى ال phagocytic cell يعنى وين ال phagocytic cell + +204 +00:18:56,820 --> 00:19:00,760 +الى أقرب blood vessels لإن ال phagocytes اللى هى + +205 +00:19:00,760 --> 00:19:05,000 +نتروفيل و ماكروفيج اللى غالبا في منها circulating + +206 +00:19:05,000 --> 00:19:10,820 +في ال blood film برفر ال blood لكن ماكروفيج ممكن + +207 +00:19:10,820 --> 00:19:13,880 +تكون موجودة فى ال tissue و ممكن circulating + +208 +00:19:15,770 --> 00:19:20,190 +طيب الفاجوسايت ريسبونس قالوا بتمر الفاجوسايت عشان + +209 +00:19:20,190 --> 00:19:24,630 +تتنشط في مراحل اختلفة اول هذه المراحل هي ال + +210 +00:19:24,630 --> 00:19:30,650 +vascular adherence يعني تتنشط لما بتصلها المواد + +211 +00:19:30,650 --> 00:19:36,890 +اللي هي اللي قلناها توقي هذه تصلها diffusing لأقرب + +212 +00:19:36,890 --> 00:19:42,040 +بلقة فازلة داية و تدل تمشي لغاية ما تخشفي الـ + +213 +00:19:42,040 --> 00:19:46,620 +peripheral blood و هناك بتنشط اللي هو neutrophil ك + +214 +00:19:46,620 --> 00:19:53,760 +example of ash of phagocytic cell فبتتنشط + +215 +00:19:53,760 --> 00:19:59,240 +بقوة رهيبية لأن أول عدود فعلها أنها بتروح بتلزج + +216 +00:19:59,240 --> 00:20:06,040 +اللي هو التنشط ال marginated neutrophil لأنه في ال + +217 +00:20:06,040 --> 00:20:11,760 +blood vesselsفي البريفرال بلد فيه هنا مارجينيتد + +218 +00:20:11,760 --> 00:20:16,160 +وفيه هنا lymph circulating pool فالمارجينيتد + +219 +00:20:16,160 --> 00:20:22,800 +بتتأثر فتروحي ملزجة في البريفرال بلد وهذه أول طبعا + +220 +00:20:22,800 --> 00:20:26,240 +خطوة من الخطوات وعملية التلزيج بتتم من خلال + +221 +00:20:26,240 --> 00:20:30,200 +receptor على سطحها وعلى سطح ال endothelial cell + +222 +00:20:30,200 --> 00:20:38,240 +المبطنة للجدار وعقدموي وطبعا أشهر هذه المبطنة + +223 +00:20:42,810 --> 00:20:46,770 +هي عبارة عن ال ICAM اللي هو intracellular adhesion + +224 +00:20:46,770 --> 00:20:51,710 +molecule one بتبطب سلكتين على سطح ال peripheral + +225 +00:20:51,710 --> 00:20:55,630 +blood على سطح ال endothelial cell المبطن لل + +226 +00:20:55,630 --> 00:20:58,190 +peripheral blood وبالتالي بيصير فيه ارتباط بعد + +227 +00:20:58,190 --> 00:21:04,690 +الارتباط بيصير فيه diabetes بتبدأ تخترق وكأنها + +228 +00:21:04,690 --> 00:21:11,980 +drill طبعا الارتباط عفوان بيعمل أول شيءتباعد بين + +229 +00:21:11,980 --> 00:21:16,680 +الخلايا لكن بيبقى الخلايا مرتبطة فكيف بدأت تنزلق + +230 +00:21:16,680 --> 00:21:20,680 +النيتروفيل الى الخارج تنزلق من خلال عملية باسمها + +231 +00:21:20,680 --> 00:21:24,660 +diabetes بيساعدها في هذه العملية افراز + +232 +00:21:24,660 --> 00:21:30,380 +collagenases انزايم بتوعية مقطع بعض الروابط عشان + +233 +00:21:30,380 --> 00:21:38,260 +تنزلق الى خارج الوعاء الدموي و هناك تبدأ مرحلة + +234 +00:21:38,260 --> 00:21:45,040 +التقللهجرة بتبدأ تتحرك chemotaxis حركة النيوتروفيل + +235 +00:21:45,040 --> 00:21:51,520 +باتجاه اللي هو ال antigen وببساطة بتتجه لل antigen + +236 +00:21:51,520 --> 00:21:57,680 +من خلال تتبعها ل chemotactic material أو source + +237 +00:21:57,680 --> 00:22:02,940 +material اللي تواجنها وبالتالي بتتتبعها + +238 +00:22:07,080 --> 00:22:10,300 +أو الـ Gradient of these materials ايش يعني؟ عليها + +239 +00:22:10,300 --> 00:22:14,940 +زيادة التركيز لان كل ما جربنا على ال Antigen كل ما + +240 +00:22:14,940 --> 00:22:20,600 +زاد تركيز هذه المواد فبصير فيه Chemotaxis وعملية + +241 +00:22:20,600 --> 00:22:25,780 +ال Chemotaxis بتنفيه نيترافيل من خلال أدة بروتينات + +242 +00:22:25,780 --> 00:22:29,860 +هي ال Profile و ال Gelulin + +243 +00:22:40,190 --> 00:22:42,710 +تصفيت الـ Actin موليكيول في الـ Cell Membrane + +244 +00:22:42,710 --> 00:22:49,170 +وبتبدأ الخلية تعمل Crawling لحركتها وبالتالي بتبقى + +245 +00:22:49,170 --> 00:22:56,790 +ماشية لغاية ما تصل إلى الـ Antigen طبعا + +246 +00:22:56,790 --> 00:23:02,050 +هناك بتتمشر وبتبدأ تعمل تتعرف على ال Antigen + +247 +00:23:02,050 --> 00:23:07,270 +وعملية التعرف على ال Antigen بتتم من خلال طريقتين + +248 +00:23:07,270 --> 00:23:14,630 +طريقة الأولانيةإنه في على سطحها pathogen + +249 +00:23:14,630 --> 00:23:20,310 +associated molecular pattern موليكيول وهذه تتعرف + +250 +00:23:20,310 --> 00:23:28,130 +على اللي هو موليكيول + +251 +00:23:28,130 --> 00:23:31,210 +موجودة على سطح اللي هو ال antigen + +252 +00:23:35,220 --> 00:23:39,900 +الـ Neutrophil بيعتبر غالبا عن specific بس ما .. + +253 +00:23:39,900 --> 00:23:45,380 +ما .. ما تتعرف بطريقة أقوى من خلال ال immune + +254 +00:23:45,380 --> 00:23:48,180 +system لإنه في .. بيكون في antibody و في + +255 +00:23:48,180 --> 00:23:52,240 +complement من سابقين ال neutrophil إلى ال antigen + +256 +00:23:52,240 --> 00:23:56,520 +و مسكين فيه و معلمين و عاملين optionized antigen + +257 +00:23:56,520 --> 00:23:59,600 +طبعا هدولة اللي لهم receptor على سطح ال neutrophil + +258 +00:23:59,600 --> 00:24:02,760 +وبالتالي بيصير في ارتباط direct ايش + +259 +00:24:06,170 --> 00:24:10,070 +الانتيجن والانتيبادي والنيتروفيل وبعد ذلك بيصير + +260 +00:24:10,070 --> 00:24:13,650 +فيه phagocytosis وبيتم عملية ال killing وهتجهتح + +261 +00:24:13,650 --> 00:24:19,650 +نشوف كيف بيتم ال killing دي هي الخطوات بالترتيب + +262 +00:24:19,650 --> 00:24:23,950 +لعملية ال phagocytosis طبعا زي ما انتوا شايفين + +263 +00:24:23,950 --> 00:24:27,410 +عبارة عن phagocytic cell على سطحة receptors لان + +264 +00:24:27,410 --> 00:24:31,890 +قولنا ال antigen بيرتبط + +265 +00:24:33,410 --> 00:24:37,170 +بالـ Neutrophil أو هى بتمسك الانتجر من خلال + +266 +00:24:37,170 --> 00:24:42,170 +الريسبتور على سطحها و الريسبتور هذه اللى هى ايضا + +267 +00:24:42,170 --> 00:24:49,270 +لجند على سطح الميكروب Escavenger Receptor FC + +268 +00:24:49,270 --> 00:24:55,190 +Receptor لل IGG ثم Complement Receptor و To Like + +269 +00:24:55,190 --> 00:24:58,950 +Receptor و دى عبارة عن + +270 +00:25:03,250 --> 00:25:07,950 +الـ phagocystic process كما انتوا شايفين نشطة + +271 +00:25:07,950 --> 00:25:11,750 +تعملت pseudo mode أي الميكروب نشطة تعملت pseudo + +272 +00:25:11,750 --> 00:25:16,110 +mode أكلت الميكروب دخل جوا الميكروب و كور حاجة + +273 +00:25:16,110 --> 00:25:18,270 +بيسموها phagosome او + +274 +00:25:20,390 --> 00:25:26,410 +في في phagocystic vesicle وطبعا بعد هي كذا بيصير + +275 +00:25:26,410 --> 00:25:30,470 +في اختلاط معايا ما بين الفاجوزوم والعيزوزوم فبتكون + +276 +00:25:30,470 --> 00:25:33,950 +حاجة باسمها فاجو والعيزوزوم طبعا هالجيتصار ال + +277 +00:25:33,950 --> 00:25:39,130 +granules موجودة وين هي و ال antigen مع بعض فبصير + +278 +00:25:39,130 --> 00:25:41,410 +عملية partially digesting + +279 +00:25:45,070 --> 00:25:55,370 +الميكروبات تقوم بتقطيع الميكروبات وبعد ذلك تقوم + +280 +00:25:55,370 --> 00:25:59,150 +بتقطيع الميكروبات تقوم بتقطيع الميكروبات تقوم + +281 +00:25:59,150 --> 00:26:00,330 +بتقطيع الميكروبات تقوم بتقطيع الميكروبات تقوم + +282 +00:26:00,330 --> 00:26:01,130 +بتقطيع الميكروبات تقوم بتقطيع الميكروبات تقوم + +283 +00:26:01,130 --> 00:26:02,670 +بتقطيع الميكروبات تقوم بتقطيع الميكروبات تقوم + +284 +00:26:02,670 --> 00:26:03,170 +بتقطيع الميكروبات تقطيع الميكروبات تقطيع + +285 +00:26:03,170 --> 00:26:07,010 +الميكروبات تقطيع الميكروبات تقطيع الميكروبات تقطيع + +286 +00:26:07,010 --> 00:26:12,390 +الميكروبات تقطيع الميكروبات تقطيع الميكروبات تقطيع + +287 +00:26:12,390 --> 00:26:16,720 +الموهذا نوعين، يا إما يدخل الـmylobrexidase في + +288 +00:26:16,720 --> 00:26:21,680 +الموضوع يا إما mylobrexidase independent ونوع تاني + +289 +00:26:21,680 --> 00:26:26,220 +اللي هو ال oxygen independent في ال oxygen + +290 +00:26:26,220 --> 00:26:26,960 +independent + +291 +00:26:29,510 --> 00:26:33,090 +طبعا بيصير في استهلاك للأكسجين بكمية كبيرة جدا و + +292 +00:26:33,090 --> 00:26:37,490 +بتبدأ تتكون سلسلة من التفاعلات الكيميائية محصلة + +293 +00:26:37,490 --> 00:26:41,390 +إنتاجها تكوين ال free radical compound كلنا بنعرف + +294 +00:26:41,390 --> 00:26:44,050 +أن ال free radical compound هي عبارة عن highly + +295 +00:26:44,050 --> 00:26:49,750 +toxic substance تعمل قتل للميكروب وتقطيعه بشكل مهم + +296 +00:26:50,010 --> 00:26:54,490 +قسموها لنوعين ميلوبرقسديز independent بيتكون فيها + +297 +00:26:54,490 --> 00:27:00,010 +القاتي ده هو الخطوات + +298 +00:27:00,010 --> 00:27:06,790 +بيتكون فيها ال super oxide و في الأول بيتكون + +299 +00:27:06,790 --> 00:27:10,270 +hydrogen radical + +300 +00:27:10,270 --> 00:27:17,490 +ثم super oxide اللي بيتفاعل مع ال hydrogen و بيكون + +301 +00:27:17,490 --> 00:27:18,490 +انه hydrogen بال + +302 +00:27:22,490 --> 00:27:26,390 +يتفاعل الهيدروجينبروكسايد مع السوباروكسايد بكونها + +303 +00:27:26,390 --> 00:27:31,530 +هيدروكسيل راديكال كومباونت وزي ما انتوا شايفين كل + +304 +00:27:31,530 --> 00:27:36,230 +المراكبات اللي علمها بالأحمر هي عبارة عن free + +305 +00:27:36,230 --> 00:27:40,970 +radical compound سوباروكسايد هيدروجينبروكسايد ثم + +306 +00:27:40,970 --> 00:27:46,790 +هيدرونيوم ايون وهيدروكسيل راديكال كومباونت في وجود + +307 +00:27:46,790 --> 00:27:51,990 +الميينوبركسديز كانوا الهيدروجينبروكسايد اللي اتكون + +308 +00:27:52,610 --> 00:27:58,010 +تتفاعل مع الكلور ويطلب مني Hypochlorite هذه عبارة + +309 +00:27:58,010 --> 00:28:02,070 +عن مادة عالية توكسيكية اللي تتفاعل في وجود الميه + +310 +00:28:02,070 --> 00:28:09,850 +ويتكون Super Oxide او Hydronium Ion وSuper Oxide + +311 +00:28:09,850 --> 00:28:13,210 +في وجود الميه يطلب مني Hydrogen Peroxide مرة تانية + +312 +00:28:16,070 --> 00:28:20,070 +طبعا الهيدروجين البروسايد في الآخر متخلص عليه منه + +313 +00:28:20,070 --> 00:28:26,270 +من خلال ال catarase enzyme اللي بيحوله لمية و ايضا + +314 +00:28:26,270 --> 00:28:35,270 +oxygen radical compound نوع التاني من ال killing + +315 +00:28:35,270 --> 00:28:37,010 +هو ال oxygen independent + +316 +00:28:40,240 --> 00:28:46,340 +يعني غالبا ضعيف لكن هو وسيلة من وسائل القتل بيعتمد + +317 +00:28:46,340 --> 00:28:50,720 +على ال granules of neutrophil وقولنا في ان + +318 +00:28:50,720 --> 00:28:56,480 +كاتايونك بروتين زي ال cathepsin اللي بيعمل تقطيع + +319 +00:28:56,480 --> 00:29:02,380 +للممرين ال isozyme أيضا بيقطع روابط البروتينيين + +320 +00:29:18,370 --> 00:29:24,870 +أيضاً في ميكانيزم آخر برضه Oxygen Independent ياله + +321 +00:29:24,870 --> 00:29:29,670 +ال Nitric Oxides بس يمسك ال microbeige بال + +322 +00:29:29,670 --> 00:29:35,490 +Receptor تبعه على سطح ال .. ال .. نترافيل وهو يمثل + +323 +00:29:35,490 --> 00:29:38,610 +the cytokine اللي هو ال human necrosis factor + +324 +00:29:38,610 --> 00:29:43,770 +وكمان أيوة، + +325 +00:29:43,770 --> 00:29:47,090 +اللي هو ال receptor على سطح الخلية نفسهااللي + +326 +00:29:47,090 --> 00:29:52,690 +بينشطها وبيجي تطلع الـ Nitric Oxide كمان بتطلع + +327 +00:29:52,690 --> 00:29:57,250 +اللي هو Gamma Interferon اللي أيضًا له Receptor + +328 +00:29:57,250 --> 00:30:02,030 +على سطح الخلية وبيطلع ال Nitric Oxide بكميات كبيرة + +329 +00:30:02,030 --> 00:30:08,670 +وهذا بيصير فيه External Killing في منطقة إياش ال + +330 +00:30:08,670 --> 00:30:14,740 +infectionهناك أشخاص أخرى بشكل مختلف في الـ Killer + +331 +00:30:14,740 --> 00:30:19,600 +Cell منها الـ NKE الـ Natural Killer و الـ Lag + +332 +00:30:19,600 --> 00:30:25,400 +Cell و الـ Killer Cell بتعتمد على الـ Antibody + +333 +00:30:25,400 --> 00:30:27,960 +Dependent Cell Mediated Cytotoxicity اللي أهنا + +334 +00:30:27,960 --> 00:30:34,100 +حنحكيها ثم Activated Macrophage و Eosinophil كلهم + +335 +00:30:34,100 --> 00:30:42,160 +بيقتلوا Foreignand altered self targets أي حد + +336 +00:30:42,160 --> 00:30:50,540 +يتصدى ل self-antigen برضه بتتم عملية قتله انكسل + +337 +00:30:50,540 --> 00:30:55,600 +تعرف عليها يعبرها برضه بيسموها large granular + +338 +00:30:55,600 --> 00:30:59,780 +lymphocytes ويقتل + +339 +00:31:00,920 --> 00:31:04,000 +الـ Infected and Malignant Cell يعني Virally + +340 +00:31:04,000 --> 00:31:08,660 +Infected Cell يعني تتعرض لكل خلية فيها + +341 +00:31:08,660 --> 00:31:13,040 +Intracellular Antigen والـ Malignant Cell نتعرف + +342 +00:31:13,040 --> 00:31:23,020 +عليها من خلال CD56 وCD16 لكن مافي CD3 اللي بيتميز + +343 +00:31:23,020 --> 00:31:26,380 +في الـ lymphocytes لأ نحن نشوف انه + +344 +00:31:29,850 --> 00:31:34,990 +أو ريسبتور للـ FC portion of IgG، بينما الـ 56 + +345 +00:31:34,990 --> 00:31:41,570 +مابنعرفش وظيفته لغاية الآن. Once this cell is + +346 +00:31:41,570 --> 00:31:46,610 +activated by Interleukin-2 and Gamma Interferon، + +347 +00:31:46,610 --> 00:31:51,330 +بتصير هذه التحول الخلية إلى activated killer cell، + +348 +00:31:51,330 --> 00:31:54,770 +lymphocyte activated killer cell. + +349 +00:32:01,440 --> 00:32:10,100 +و ال IL-2 قتل ماشي من خلال إفراز certain enzyme + +350 +00:32:10,100 --> 00:32:17,640 +اللي موجودة في ال granules تبعتها ال + +351 +00:32:17,640 --> 00:32:23,520 +malignant cell و ال virally infected cell طب كيف + +352 +00:32:23,520 --> 00:32:28,120 +أنا أتحكم في وظيفة هذه الخلية ال ankyl cell كانوا + +353 +00:32:28,120 --> 00:32:34,720 +فيها على سطحهاتو ريسبتور واحد اسمه KIR Killing + +354 +00:32:34,720 --> 00:32:41,620 +Inhibitory Receptor واحد اسمه KAR Killing + +355 +00:32:41,620 --> 00:32:50,040 +Activating Receptor الاولاني ال KIR is receptor + +356 +00:32:50,040 --> 00:32:58,920 +for MHC molecule بينما ال KAR + +357 +00:33:01,360 --> 00:33:05,560 +هو عبارة عن Killing Receptor بس يرتبط بالـ Legion + +358 +00:33:05,560 --> 00:33:10,700 +تبعه اللي هو الـ KAL على طول بيصير فيه قتل للخلية + +359 +00:33:10,700 --> 00:33:16,640 +كيف يتم هذا الموضوع ببساطة الخلية المصابة سواء + +360 +00:33:16,640 --> 00:33:20,860 +كانت Malignant Cell أو Virally Infected Cell نسبة + +361 +00:33:20,860 --> 00:33:29,440 +ال MHC Molecule اللي على سطحها بتقل فإذا قلتالخلية + +362 +00:33:29,440 --> 00:33:33,460 +هذه اللي هي ال NK cell الرسبتور اللي على السطح + +363 +00:33:33,460 --> 00:33:37,340 +اللي هو بيسموه killing activating receptor بيجي و + +364 +00:33:37,340 --> 00:33:41,900 +بتطلع الخلية و لايجيش شي مرتبط فيها فمرتبط بال لجن + +365 +00:33:41,900 --> 00:33:47,380 +تبع مين تبع ال killing و بقتل الخلية طب في الوضع + +366 +00:33:47,380 --> 00:33:50,300 +الطبيعي شو اللي بيصير؟ يعني الوضع الطبيعي الخلية + +367 +00:33:50,300 --> 00:33:53,660 +الطبيعية على سطحها MHC molecule بتايتها العالي + +368 +00:33:54,870 --> 00:34:02,350 +وبالتالي أول ما تطبط أو تمسك ال K لان K سلب الخلية + +369 +00:34:02,350 --> 00:34:07,970 +السليمة على طول بمسك ال MHC موليكيول بالرسيبتوري + +370 +00:34:07,970 --> 00:34:11,730 +اللي على سطحها وبالتالي بتعرف أن هذه الخلية خلية + +371 +00:34:11,730 --> 00:34:19,210 +سليمة once يعني incubated بمجرد ما يشغل ال KIR + +372 +00:34:19,210 --> 00:34:24,490 +معناته في وقف لعملية القتليبقى عشان عيدها بمعصرية + +373 +00:34:24,490 --> 00:34:29,030 +مرة تانية عملية الانكس على السطحة دول الceptors + +374 +00:34:29,030 --> 00:34:30,390 +واحد منهم + +375 +00:34:37,650 --> 00:34:41,050 +الخلية السليمة على سطحها MSC مونيكول في الوضع + +376 +00:34:41,050 --> 00:34:47,430 +الطبيعي وبالتالي بمجرد ما تمسك فيها تمسك ال MSC + +377 +00:34:47,430 --> 00:34:51,690 +بال KIR Inhibitory Receptor فبعمل Inhibition + +378 +00:34:51,690 --> 00:34:56,680 +للخلية وبالتالي ببدأ عملية القتلبينما إذا مافيش .. + +379 +00:34:56,680 --> 00:35:00,800 +إذا كان في خدية مصابة مافيش MRC molecule وبالتالي + +380 +00:35:00,800 --> 00:35:09,120 +ال receptor القاتل أو KAR بدي يمسك من legend تبع + +381 +00:35:09,120 --> 00:35:12,520 +القتل وبالتالي بيصير عملية قتل للخدية + +382 +00:35:14,770 --> 00:35:19,090 +الـ Killing Cell أيضًا Killer Cell أيضًا بتلعب دور + +383 +00:35:19,090 --> 00:35:24,950 +كبير من خلال اعتمادها على وجود Antibody على سطح + +384 +00:35:24,950 --> 00:35:30,350 +اللي هو الخلية المصعبة طبعًا إيش جاب ال Antibody + +385 +00:35:30,350 --> 00:35:34,690 +احنا قلنا إنه بس يخش فيه Antigen بيتنشط جهاز + +386 +00:35:34,690 --> 00:35:41,270 +المناع فببدأ يكوّن إيش Antibody لـ Micro + +387 +00:35:44,140 --> 00:35:48,820 +أو الخلية المصابة وبيتي بعلمهالأنه في على سطحها + +388 +00:35:48,820 --> 00:35:53,840 +ايش؟ على سطحها انتيجينات فبيجي بنسيك فيها سواء كان + +389 +00:35:53,840 --> 00:35:58,800 +بده التصنيع ال antibody أو ال already secreted + +390 +00:35:58,800 --> 00:36:03,860 +antibody اللي لما بمسيك فيها بمسيك من خلال ال fab + +391 +00:36:03,860 --> 00:36:07,980 +region اللي بيبقى الفالت اللي بيبقى الفالت اللي هو + +392 +00:36:07,980 --> 00:36:12,520 +ال FC region of antibody اللي ال antibody بيربط مع + +393 +00:36:12,520 --> 00:36:19,450 +ال antigen اللي على سطح الخلية من خلال الانتجن + +394 +00:36:19,450 --> 00:36:25,210 +بايندنج انتجن + +395 +00:36:25,210 --> 00:36:30,470 +بايندنج انتجن بايندنج انتجن بايندنج انتجن بايندنج + +396 +00:36:30,470 --> 00:36:31,030 +انتجن بايندنج انتجن بايندنج انتجن بايندنج انتجن + +397 +00:36:31,030 --> 00:36:31,170 +بايندنج انتجن بايندنج انتجن بايندنج انتجن بايندنج + +398 +00:36:31,170 --> 00:36:31,490 +انتجن بايندنج انتجن بايندنج انتجن بايندنج انتجن + +399 +00:36:31,490 --> 00:36:32,670 +بايندنج انتجن بايندنج انتجن بايندنج انتجن بايندنج + +400 +00:36:32,670 --> 00:36:42,450 +انتجن بايندنج انتجن بايندنج انتجن بايندنج + +401 +00:36:46,780 --> 00:36:51,640 +هي morphologically الـ killer cell undefined لكنها + +402 +00:36:51,640 --> 00:36:57,760 +ريسبتر اللي هو الفسيبوجيو YGG وبتتعرف على الخلايا + +403 +00:36:57,760 --> 00:37:04,560 +ال optionized اللي هي coated with antibody و ال + +404 +00:37:04,560 --> 00:37:06,460 +could be enkei cell + +405 +00:37:09,440 --> 00:37:14,260 +طبعاً في هذه الحالة على سطح IGG ريسبتر ل FC + +406 +00:37:14,260 --> 00:37:18,700 +portion of IGG مايكروفيجي نفس الحكاية الذين فيه + +407 +00:37:18,700 --> 00:37:24,480 +تتعرف على ال IG .. ال FC portion of IGE مش IGG + +408 +00:37:24,480 --> 00:37:30,720 +طبعاً في معظم الفجوس ال Excel اللي هي ريسبتر لل FC + +409 +00:37:30,720 --> 00:37:31,940 +portion of IGG + +410 +00:37:38,970 --> 00:37:44,930 +طبعا في summary two-slided في summary للمحاضرة + +411 +00:37:44,930 --> 00:37:52,030 +كلها يوميادي عبارة عن محاضرة دربنا فيها مثال عن ال + +412 +00:37:52,030 --> 00:37:56,350 +cellular part + +413 +00:37:56,350 --> 00:37:59,810 +of innate immunity وهو الفاجوس التكسيل في محاضرة + +414 +00:37:59,810 --> 00:38:04,290 +قادمة ان شاء الله هنتطرق لهيومرا ال part من خلال + +415 +00:38:04,290 --> 00:38:07,910 +شريحنا لل compliment وشكرا + diff --git a/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/_Zm74aS0kIU_raw.srt b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/_Zm74aS0kIU_raw.srt new file mode 100644 index 0000000000000000000000000000000000000000..3f511cbb1354f664bdfc930c125a7fb52e3955fc --- /dev/null +++ b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/_Zm74aS0kIU_raw.srt @@ -0,0 +1,1676 @@ +1 +00:00:02,430 --> 00:00:05,830 +بسم الله الرحمن الرحيم و بيه نستعين و عليه نتوكل + +2 +00:00:05,830 --> 00:00:12,810 +أجمعين كنا قد صنفنا المناعة الى innate و acquired + +3 +00:00:12,810 --> 00:00:19,470 +immunity في محاضرة سابقة و اليوم ان شاء الله هناخد + +4 +00:00:19,470 --> 00:00:26,750 +أنثى على ال innate immunity في محاضرتين ثم نتطلق + +5 +00:00:26,750 --> 00:00:29,690 +الى ال acquired immunity بتفاصيلتها المختلفة + +6 +00:00:34,650 --> 00:00:41,290 +فاتعرفنا أيضا على أدواتها المختلفة ومن أدواتها انه + +7 +00:00:41,290 --> 00:00:45,310 +الان + +8 +00:00:45,310 --> 00:00:50,990 +هنصنفهم الهيومرال وcellular ويدعونا لنا السابق + +9 +00:00:50,990 --> 00:00:53,970 +الأحداث فلنبدأ على بركة الله + +10 +00:00:59,770 --> 00:01:05,830 +طبعا كنا بنعرف انه .. ايضا في مقدمة المرة اللى + +11 +00:01:05,830 --> 00:01:11,590 +فاتت انه ال .. كل خلايا الجسم تلعب دور كبير في + +12 +00:01:11,590 --> 00:01:15,150 +مناعة الجسم و ايضا قسمنا ال .. + +13 +00:01:18,210 --> 00:01:23,890 +وخلايا تعمل في ال acquired immunity وقلنا ان ال + +14 +00:01:23,890 --> 00:01:28,050 +innate immunity كل الخلايا معاد ال lymphocytes + +15 +00:01:28,050 --> 00:01:33,530 +تلعب دور كبير في ال innate immunity وان ال + +16 +00:01:33,530 --> 00:01:36,670 +acquired immunity ال major cells فيها هي ال + +17 +00:01:36,670 --> 00:01:40,990 +lymphocyte بنوعها ال B وT lymphocyte ولاحقا ننسى + +18 +00:01:40,990 --> 00:01:46,060 +ان في collaboration between these cellsهذا طبعا + +19 +00:01:46,060 --> 00:01:51,240 +الـ Hemopoietic Tree للتذكير عشان نتعرف على مصادر + +20 +00:01:51,240 --> 00:01:58,160 +هذه الخلايا اللي جاية أصلا من البونمانو Myl + +21 +00:01:58,160 --> 00:02:02,780 +-T cell قسمها طبعا زي ما اتفقنا إلى Myloid + +22 +00:02:02,780 --> 00:02:07,600 +وLymphoid واتفقنا على أن Myloid هي عبارة عن + +23 +00:02:07,600 --> 00:02:11,910 +Granulocytic وMonocyticالـ Granulocyte نعرفها هي + +24 +00:02:11,910 --> 00:02:16,410 +نيتروفيل وبيزوفيل وإيزوفريل بينما الـ monocytic + +25 +00:02:16,410 --> 00:02:22,330 +تتحول إلى ال macrophage بأنواعها منها Langerhans + +26 +00:02:22,330 --> 00:02:27,090 +وكفارف وDendritic cell بينما ال lymphoid فهي T + +27 +00:02:27,090 --> 00:02:30,850 +cell وB cellو الـ T cell ان شاء الله هتتطرخ + +28 +00:02:30,850 --> 00:02:36,670 +لأنواعها أشهر أنواعها هي البرسيل و هي ال cytotoxic + +29 +00:02:36,670 --> 00:02:42,030 +T cell و ال suppressor و في نوعه كمان مهم هو + +30 +00:02:42,030 --> 00:02:47,290 +delayed type hypersensitivity أما ال B lymphocyte + +31 +00:02:47,290 --> 00:02:53,390 +فبتتحول إلى plasma cell اللي بتدينها ال antibody و + +32 +00:02:53,390 --> 00:02:56,790 +هي الdendritic cell أنا مصنفينها على أنها هي ال + +33 +00:02:56,790 --> 00:03:01,150 +lymphoidوإن كان لغاية الآن احنا ما بنعرف المصدر + +34 +00:03:01,150 --> 00:03:07,770 +الأساسي تبعها هل هي ال infoid ولا myeloid قسموا ال + +35 +00:03:07,770 --> 00:03:13,140 +immune system إلى زي ما قلنا لكم وينnon-specific + +36 +00:03:13,140 --> 00:03:17,660 +اللي مقصود فيها innate immunity وspecific اللي + +37 +00:03:17,660 --> 00:03:22,280 +مقصود فيها acquired immunity وكل واحدة منهم قسموها + +38 +00:03:22,280 --> 00:03:28,860 +إلى نوعين non-specific humoral وcellular وspecific + +39 +00:03:28,860 --> 00:03:33,440 +أيضا humoral وcellular في ال non-specific ال + +40 +00:03:33,440 --> 00:03:37,620 +humoralيتمثل بالـ complement بالـ interferon بـ + +41 +00:03:37,620 --> 00:03:42,600 +tumors نكروسيز فاكتور وفي مجموعة كبيرة من ال + +42 +00:03:42,600 --> 00:03:48,360 +secreted protein أيضا بتندرج تحت هذه القائمة بينما + +43 +00:03:48,360 --> 00:03:52,240 +ال cellular هي ال phagocytic cell و ال phagocytic + +44 +00:03:52,240 --> 00:03:55,760 +أشهر ال phagocytic cell هي او ال professional + +45 +00:03:55,760 --> 00:03:59,800 +بيسموها phagocytic cell هي ال macrophage و ال + +46 +00:03:59,800 --> 00:04:07,450 +neutrophil بينما ال specificأيضًا قسموها لقسمين، + +47 +00:04:07,450 --> 00:04:10,330 +اللي هي Umrah لـ Cellular اللي هي Umrah المتمثلة + +48 +00:04:10,330 --> 00:04:14,450 +بالـ B-Lymphocytes ودورها في إنتاج الـ Antibody + +49 +00:04:14,450 --> 00:04:18,730 +بينما Cellular متمثلة بالـ Cell Mediated Immunity + +50 +00:04:18,730 --> 00:04:25,170 +و اللي بتقوم فيها الـ T Cell و Other Effector Cell + +51 +00:04:25,170 --> 00:04:28,770 +قبل + +52 +00:04:28,770 --> 00:04:30,690 +ما نبدأ في ال .. + +53 +00:04:33,710 --> 00:04:45,810 +التفصيلات هذه دي دي دي دي + +54 +00:04:45,810 --> 00:04:46,090 +دي دي دي دي دي دي دي دي دي دي دي دي دي دي دي دي دي + +55 +00:04:46,090 --> 00:04:46,390 +دي دي دي دي دي دي دي دي دي دي دي دي دي دي دي دي دي + +56 +00:04:46,390 --> 00:04:46,390 +دي دي دي دي دي دي دي دي دي دي دي دي دي دي دي دي دي + +57 +00:04:46,390 --> 00:04:46,390 +دي دي دي دي دي دي دي دي دي دي دي دي دي دي دي دي دي + +58 +00:04:46,390 --> 00:04:46,890 +دي دي دي دي دي دي دي دي دي دي دي دي دي دي دي دي دي + +59 +00:04:46,890 --> 00:04:52,050 +دي دي دي + +60 +00:04:52,050 --> 00:05:02,970 +دي دي دي دي دي دي دي دي دي دي دي دي دي دي دي دي د + +61 +00:05:03,310 --> 00:05:11,690 +بينترج او بيحسن بعدد مرات ال infection في ال + +62 +00:05:11,690 --> 00:05:18,410 +variance of infection شدته لالتهاب على ال immunity + +63 +00:05:18,410 --> 00:05:22,070 +على ال immunity طبعا اي خلل في هذا الميزان هيدي + +64 +00:05:22,070 --> 00:05:28,190 +اما الى الحالة المرضية وهو الحالة + +65 +00:05:38,880 --> 00:05:42,320 +Infection كالقاتي انه لما الإنسان يتعرض إلى + +66 +00:05:42,320 --> 00:05:49,100 +infection تتصدى له ال innate immunity و بما إنها + +67 +00:05:49,100 --> 00:05:53,240 +هي ال first line defense mechanism و الأصل إنه إذا + +68 +00:05:53,240 --> 00:05:57,720 +اشتغلت يصير no disease لأنها بتعمل prevention for + +69 +00:05:57,720 --> 00:06:03,280 +infectious agent entry تمنع دخول اللي هو + +70 +00:06:03,280 --> 00:06:05,460 +infectious agent + +71 +00:06:11,500 --> 00:06:16,980 +طبعا اذا مافيش innate immunity او مشتغلتش منيح + +72 +00:06:16,980 --> 00:06:22,860 +انسان بيصير في عنده disease و بعد ال disease + +73 +00:06:22,860 --> 00:06:28,860 +بيكتسب بناعة after recovery و بيصير عنده adaptive + +74 +00:06:28,860 --> 00:06:33,580 +immunity بيصير عنده adaptive immunity و احنا قلنا + +75 +00:06:33,580 --> 00:06:38,940 +ان اصلا ال adaptive immunity بتنتج من خلال تعرض ال + +76 +00:06:38,940 --> 00:06:39,840 +active form + +77 +00:06:44,440 --> 00:06:51,000 +الإنفكشن على ال adaptive immunity upon reinfection + +78 +00:06:51,000 --> 00:06:58,420 +على طول تتصدى للميكروب لأنه أصلا من اسم adaptive + +79 +00:06:58,420 --> 00:07:01,600 +immunity في memory cell بتتعرف على ميكروب و بتتصدى + +80 +00:07:01,600 --> 00:07:05,740 +له مباشرة و تالي there is no disease لكن إذا لا + +81 +00:07:05,740 --> 00:07:11,120 +مافي adaptive immunity ودخل الميكروب نتيجة خلل في + +82 +00:07:11,120 --> 00:07:16,750 +ال innate immunityمعناته المحصلة هي الوفاة لإنسان + +83 +00:07:16,750 --> 00:07:24,710 +بدون مناعة وبالتالي هيموت طيب إيش ال significance + +84 +00:07:24,710 --> 00:07:30,290 +of the immune system قالوا له فوائد متعددة منها ال + +85 +00:07:30,290 --> 00:07:34,350 +protection of invader and eliminating of altered + +86 +00:07:34,350 --> 00:07:39,010 +cell طبيعي جدا الخلايا ال self-reacted cell ال + +87 +00:07:39,010 --> 00:07:45,050 +self-reacted cell أصلا بالجسمبقتلها أول بأول مين + +88 +00:07:45,050 --> 00:07:48,270 +بيقول طبعا بيكب بيقتلها بيقتلها بيادوات منعية + +89 +00:07:48,270 --> 00:07:54,410 +بينما المساوق + +90 +00:07:54,410 --> 00:07:57,590 +تبعت + +91 +00:07:57,590 --> 00:08:00,030 +ال immune response أنا مانديش أقول مساوق خلينا + +92 +00:08:00,030 --> 00:08:02,330 +نقول الأذية اللي بتيجي + +93 +00:08:12,140 --> 00:08:17,280 +inflammationوكلنا عارفين ال inflammatory signs and + +94 +00:08:17,280 --> 00:08:23,780 +symptoms بتتمثل بعدة إيش؟ بعدة صفات من ال redness + +95 +00:08:23,780 --> 00:08:29,640 +و ال hotness و ال pain و طبعا ممكن يصير في loss of + +96 +00:08:29,640 --> 00:08:34,880 +function إذا استمر الموضوع فطبعا هذه بحد ذاتها هي + +97 +00:08:34,880 --> 00:08:42,020 +نوع بتؤثر أو بتسبب أذية و عدم راحة للإنسان + +98 +00:08:43,310 --> 00:08:49,130 +الحاجة التانية أنه ممكن جهاز المناع يخش في مسلك + +99 +00:08:49,130 --> 00:08:55,350 +خاطئ ويسبب اللي هو auto immunity disease نتيجة + +100 +00:08:55,350 --> 00:08:59,170 +مهاجمته for self-antigen + +101 +00:09:08,130 --> 00:09:12,890 +بتشتغل كـ First Line Defense Mechanism بغض النظر + +102 +00:09:12,890 --> 00:09:17,490 +عن نوع الـ Antigen اللي دخل على عكس الـ Adaptive + +103 +00:09:17,490 --> 00:09:24,970 +اللي بتشتغل فقط في وجود الـ Antigen و الـ innate + +104 +00:09:24,970 --> 00:09:28,930 +there is no time lag بمعناه محتاجش إلى incubation + +105 +00:09:28,930 --> 00:09:33,770 +period بينما ال Adaptive محتاج إلى lag period + +106 +00:09:38,660 --> 00:09:52,180 +الانتجينات ليست مخصصة للانتجين لان + +107 +00:09:52,180 --> 00:09:57,980 +لا يوجد ذاكرة نهاروزيكال لكن الانتجينات تعمل ذاكرة + +108 +00:09:57,980 --> 00:10:02,180 +ذاكرة الانتجين + +109 +00:10:04,920 --> 00:10:08,000 +ال component of innate and acquired immunity + +110 +00:10:08,000 --> 00:10:12,340 +قسموها إلى physical barriers وهذه موجودة في ال + +111 +00:10:12,340 --> 00:10:16,400 +innate و متمثلة بال skin و ال gut في الاعي و ال + +112 +00:10:16,400 --> 00:10:21,060 +lung and cilia و ده وقت كثير عرفت اتفصلها قدام + +113 +00:10:21,060 --> 00:10:28,020 +بينما في ال adaptive مافي physical barrierسوليابل + +114 +00:10:28,020 --> 00:10:31,400 +فاكتورز جاله في الانتباد فيه طبعا ماني بروتين ومان + +115 +00:10:31,400 --> 00:10:38,300 +بروتين سيكريشن وحنضرب أنثى لقدام بينما في ال + +116 +00:10:38,300 --> 00:10:46,320 +adaptive ال antibody هو ال form اللي يفرز من ال + +117 +00:10:46,320 --> 00:10:50,360 +adaptive بالنسبال الخلايا في ال innate في عندنا + +118 +00:10:50,360 --> 00:10:51,160 +الفاجوستيكس + +119 +00:10:55,040 --> 00:11:01,700 +زينفيل وال K سل و هنجي ان شاء الله في هذه المحاضرة + +120 +00:11:01,700 --> 00:11:07,400 +هنتطرق لتفصيلات عنها بينما الخلايا في ال adaptive + +121 +00:11:07,400 --> 00:11:11,020 +immunity هي ال T و B lymphocytes + +122 +00:11:15,710 --> 00:11:22,890 +طبعا ال .. ال .. هذه صورة figure ببين لنا على إن + +123 +00:11:22,890 --> 00:11:29,950 +الإنسان physically is a closed system وبالتالي في + +124 +00:11:29,950 --> 00:11:35,130 +physical barrier تمنع دخول أياش any antigen لكن + +125 +00:11:35,130 --> 00:11:41,070 +once this circle is broken من خلال nail من خلال + +126 +00:11:41,070 --> 00:11:48,080 +burns من خلال whateverهيدخل ال microbe و هيكون + +127 +00:11:48,080 --> 00:11:57,500 +بيئة خصبة لنشاط ال anaerobic bacteria طيب ما هي + +128 +00:11:57,500 --> 00:12:01,080 +الأدوات المنعية ال mechanismات المنعية اللي بتتم + +129 +00:12:01,080 --> 00:12:06,140 +في كل نوع من هذه الأنواع خلينا نشوف ال innate و + +130 +00:12:06,140 --> 00:12:09,700 +بعدين نتطرق للأكوان اللي في ال innate احنا اتفقنا + +131 +00:12:09,700 --> 00:12:13,740 +ان في skinو ال skin اللى بلعب دور كبير فى ال skin + +132 +00:12:13,740 --> 00:12:18,680 +squamous cell بتعمل continuous desquamation و فيه + +133 +00:12:18,680 --> 00:12:24,260 +suite بعمل flushing continuous فى غسيل دائم و فيها + +134 +00:12:24,260 --> 00:12:29,560 +fatty acid اللى عبارة عن antibacterial فى ال + +135 +00:12:29,560 --> 00:12:34,060 +gastrointestinal tract فى culinary cells و ال + +136 +00:12:34,060 --> 00:12:38,790 +culinary cells مشهورة بال peristalsismovement اللي + +137 +00:12:38,790 --> 00:12:42,790 +هي الحركات الدودية كمان في low pH في ال stomach + +138 +00:12:42,790 --> 00:12:47,450 +كمان في bile holes في ال gas في ال pancreatic + +139 +00:12:47,450 --> 00:12:51,690 +secretion وفي fatty acids وكل هذه عبارة عن + +140 +00:12:51,690 --> 00:12:56,640 +antibacterial ال lung فيها tracheal cellوالـ + +141 +00:12:56,640 --> 00:13:00,440 +Tracheal cell بتعرفين بتعمل فيها ميوكس سيلياري ب + +142 +00:13:00,440 --> 00:13:08,180 +elevator تعريضة لإيش لأي foreign substance من خلال + +143 +00:13:08,180 --> 00:13:12,220 +الحركة من خلال ال ميوكس اللي موجود فيها + +144 +00:13:12,220 --> 00:13:20,200 +نيزوفيرانكس and I في النوع .. في طبعا في ميوكاس و + +145 +00:13:20,200 --> 00:13:24,810 +في saliva و في tearsوهذه بتعمل continuous flushing + +146 +00:13:24,810 --> 00:13:31,350 +و هي بتحتوي على ال isozymes لبلاد و لينفويد organs + +147 +00:13:31,350 --> 00:13:37,590 +طبعا ال phagocytes أشهرها و هي بتعمل phagocytosis + +148 +00:13:37,590 --> 00:13:39,550 +و intracellular killing + +149 +00:14:00,250 --> 00:14:08,730 +الخلايا الاصابع بانتيجين الاندريكتأو تعتمد على + +150 +00:14:08,730 --> 00:14:16,770 +وجود Antibody-dependent cytolysis أيضًا + +151 +00:14:16,770 --> 00:14:19,350 +من أدوات الـ Innate Immunity الـ Serum قد في + +152 +00:14:19,350 --> 00:14:23,490 +سيراسيفلود فيها الأكتفيرين و الترانسفيرين و هذا + +153 +00:14:23,490 --> 00:14:28,310 +بيعمل Deprevation للعيرون بشخط العيرون فيها + +154 +00:14:28,310 --> 00:14:31,910 +Interferon و هي tumor necrosis factor و هذا مش + +155 +00:14:31,910 --> 00:14:36,770 +تقوله ك Antiviral لبروتينوهي بنشطه الفاجوسيتكسل + +156 +00:14:36,770 --> 00:14:40,070 +فيها الازوزايم وهذه عبارة عن + +157 +00:14:40,070 --> 00:14:43,830 +بيبتايدوكلايكينهيدروليسيز بتقطع روابط الاشهر + +158 +00:14:43,830 --> 00:14:47,970 +لبروتينية ثم فيبرنكتين and complement وطبعا + +159 +00:14:47,970 --> 00:14:51,370 +وظيفتها optionization و enhancement of + +160 +00:14:51,370 --> 00:14:57,470 +phagocytosis وبتعمل inflammation ماهي + +161 +00:14:57,470 --> 00:15:04,160 +أشهر الفاجوسيتكسل طبعا الأن حاجة تتفرق ليهالكن من + +162 +00:15:04,160 --> 00:15:09,100 +المقولات المشهورة عن ال Fagocytic عن أهمية ال + +163 +00:15:09,100 --> 00:15:13,760 +Fagocytes كان Bernard Shaw وهو عبارة عن كاتب + +164 +00:15:13,760 --> 00:15:20,220 +إنجليزي عاش في القرن السادس عشر والسبع عشر قال في + +165 +00:15:20,220 --> 00:15:22,760 +أحد كتاباته أنه + +166 +00:15:26,420 --> 00:15:33,420 +for all diseases في أحمقنا في علاج واحد لكل + +167 +00:15:33,420 --> 00:15:38,360 +الأبراد اللي في الدنيا ايش هو قالوا ت stimulate + +168 +00:15:38,360 --> 00:15:42,380 +phagocyte انك اتنشط ال phagocytes واش بقول عن ال + +169 +00:15:42,380 --> 00:15:48,320 +drugs بقول ال drugs are delusion يعني خرافة انما + +170 +00:15:48,320 --> 00:15:52,860 +when the phagocytes are stimulated they divorce + +171 +00:15:56,090 --> 00:16:02,930 +فاجوسايتز بتخلصنا من إيش من المرض و طبعا زى ما + +172 +00:16:02,930 --> 00:16:07,270 +قلنا الفاجوسيتكسيل الشهرها في أنانوعين + +173 +00:16:07,270 --> 00:16:14,310 +professional و non specific الماكروفيج مهم جدا + +174 +00:16:14,310 --> 00:16:18,790 +تعمل فاجوسيتوسيز لإنترا و extra cellular killing + +175 +00:16:20,660 --> 00:16:23,960 +بتعمل تشيري بير تعمل انتجين presentation for + +176 +00:16:23,960 --> 00:16:26,760 +specific immune response و هتشوف دول عبارة عن + +177 +00:16:26,760 --> 00:16:31,880 +مظائف يعني بالمجمل لكن لها six different function + +178 +00:16:31,880 --> 00:16:37,580 +هنتطرق عليهم في المدام نتعرف عليها ال macro fish + +179 +00:16:37,580 --> 00:16:44,740 +من خلال سلسة surface market وهو CD14 ال neutrophil + +180 +00:16:44,740 --> 00:16:46,620 +أيضا + +181 +00:16:48,130 --> 00:16:54,070 +هي عبارة عن ال other potent immunophagocytic cell + +182 +00:16:54,070 --> 00:16:58,290 +تحتوي على granules سواء كانت ال primary ولا ال + +183 +00:16:58,290 --> 00:17:06,430 +secondary طبعا و tertiary كمان بس أهم شغلتين + +184 +00:17:06,430 --> 00:17:11,630 +بتتميز هي ال primary و ال secondary ال primary + +185 +00:17:11,630 --> 00:17:15,070 +granules جالوا عبارة عن azirophilic granules و + +186 +00:17:15,070 --> 00:17:19,110 +موجودة غالبا في ال young neutrophilبينما الـ + +187 +00:17:19,110 --> 00:17:25,870 +secondary أجرانيال هي أبعاد أجرانيال موجودة في الـ + +188 +00:17:25,870 --> 00:17:31,310 +mature نيوتروفيل ال + +189 +00:17:31,310 --> 00:17:37,570 +primary granules بيها enzymes كثيرة فيها ال + +190 +00:17:37,570 --> 00:17:40,970 +isozyme و ال defensive و ال proteases لكن ما + +191 +00:17:40,970 --> 00:17:45,490 +يميزها وجود ال myroproxidase enzyme بينما ال + +192 +00:17:45,490 --> 00:17:51,240 +secondary أيضا تحتوي علىالليزوزايم تحتوي على اخر + +193 +00:17:51,240 --> 00:17:56,060 +انزايم مهمة + +194 +00:17:56,060 --> 00:17:58,060 +مثل ناد بي اتش اكسيديزي ناد بي اتش اكسيديزي ناد بي + +195 +00:17:58,060 --> 00:17:59,000 +اتش اكسيديزي ناد بي اتش اكسيديزي ناد بي اتش + +196 +00:17:59,000 --> 00:18:01,740 +اكسيديزي ناد بي اتش اكسيديزي ناد بي اتش اكسيديزي + +197 +00:18:01,740 --> 00:18:02,900 +ناد بي اتش اكسيديزي ناد بي اتش اكسيديزي ناد بي اتش + +198 +00:18:02,900 --> 00:18:07,120 +اكسيديزي ناد بي اتش اكسيديزي ناد بي اتش اكسيديزي + +199 +00:18:07,120 --> 00:18:14,860 +ناد بي اتش اكسيديزي ناد بي اتش اكسيديزي ناد بي ات + +200 +00:18:15,300 --> 00:18:24,280 +تتحسس الـ SOS Signal 707 وهذه عبارة عن أدوات + +201 +00:18:24,280 --> 00:18:30,500 +كيميائية بتصل من خلال البكتيريا إفرازات البكتيريا + +202 +00:18:30,500 --> 00:18:37,020 +والخلايا المضامرة مثل الانفرمي الميثيونين مثل وجود + +203 +00:18:37,020 --> 00:18:40,740 +Clotting System Peptide upon infection + +204 +00:18:44,280 --> 00:18:53,760 +كلها هادى بتتولد فى منطقة ال infection و بتهاجر + +205 +00:18:53,760 --> 00:18:56,820 +الى ال phagocytic cell يعنى وين ال phagocytic cell + +206 +00:18:56,820 --> 00:19:00,760 +الى أقرب blood vessels لإن ال phagocytes اللى هى + +207 +00:19:00,760 --> 00:19:05,000 +نتروفيل و ماكروفيج اللى غالبا في منها circulating + +208 +00:19:05,000 --> 00:19:10,820 +في ال blood film برفر ال blood لكن ماكروفيج ممكن + +209 +00:19:10,820 --> 00:19:13,880 +تكون موجودة فى ال tissue و ممكن circulating + +210 +00:19:15,770 --> 00:19:20,190 +طيب الفاجوسايت ريسبونس قالوا بتمر الفاجوسايت عشان + +211 +00:19:20,190 --> 00:19:24,630 +تتنشط في مراحل اختلفة اول هذه المراحل هي ال + +212 +00:19:24,630 --> 00:19:30,650 +vascular adherence يعني تتنشط لما بتصلها المواد + +213 +00:19:30,650 --> 00:19:36,890 +اللي هي اللي قلناها توقي هذه تصلها diffusing لأقرب + +214 +00:19:36,890 --> 00:19:42,040 +بلقة فازلة داية و تدل تمشي لغاية ما تخشفي الـ + +215 +00:19:42,040 --> 00:19:46,620 +peripheral blood و هناك بتنشط اللي هو neutrophil ك + +216 +00:19:46,620 --> 00:19:53,760 +example of ash of phagocytic cell فبتتنشط + +217 +00:19:53,760 --> 00:19:59,240 +بقوة رهيبية لأن أول عدود فعلها أنها بتروح بتلزج + +218 +00:19:59,240 --> 00:20:06,040 +اللي هو التنشط ال marginated neutrophil لأنه في ال + +219 +00:20:06,040 --> 00:20:11,760 +blood vesselsفي البريفرال بلد فيه هنا مارجينيتد + +220 +00:20:11,760 --> 00:20:16,160 +وفيه هنا lymph circulating pool فالمارجينيتد + +221 +00:20:16,160 --> 00:20:22,800 +بتتأثر فتروحي ملزجة في البريفرال بلد وهذه أول طبعا + +222 +00:20:22,800 --> 00:20:26,240 +خطوة من الخطوات وعملية التلزيج بتتم من خلال + +223 +00:20:26,240 --> 00:20:30,200 +receptor على سطحها وعلى سطح ال endothelial cell + +224 +00:20:30,200 --> 00:20:38,240 +المبطنة للجدار وعقدموي وطبعا أشهر هذه المبطنة + +225 +00:20:42,810 --> 00:20:46,770 +هي عبارة عن ال ICAM اللي هو intracellular adhesion + +226 +00:20:46,770 --> 00:20:51,710 +molecule one بتبطب سلكتين على سطح ال peripheral + +227 +00:20:51,710 --> 00:20:55,630 +blood على سطح ال endothelial cell المبطن لل + +228 +00:20:55,630 --> 00:20:58,190 +peripheral blood وبالتالي بيصير فيه ارتباط بعد + +229 +00:20:58,190 --> 00:21:04,690 +الارتباط بيصير فيه diabetes بتبدأ تخترق وكأنها + +230 +00:21:04,690 --> 00:21:11,980 +drill طبعا الارتباط عفوان بيعمل أول شيءتباعد بين + +231 +00:21:11,980 --> 00:21:16,680 +الخلايا لكن بيبقى الخلايا مرتبطة فكيف بدأت تنزلق + +232 +00:21:16,680 --> 00:21:20,680 +النيتروفيل الى الخارج تنزلق من خلال عملية باسمها + +233 +00:21:20,680 --> 00:21:24,660 +diabetes بيساعدها في هذه العملية افراز + +234 +00:21:24,660 --> 00:21:30,380 +collagenases انزايم بتوعية مقطع بعض الروابط عشان + +235 +00:21:30,380 --> 00:21:38,260 +تنزلق الى خارج الوعاء الدموي و هناك تبدأ مرحلة + +236 +00:21:38,260 --> 00:21:45,040 +التقللهجرة بتبدأ تتحرك chemotaxis حركة النيوتروفيل + +237 +00:21:45,040 --> 00:21:51,520 +باتجاه اللي هو ال antigen وببساطة بتتجه لل antigen + +238 +00:21:51,520 --> 00:21:57,680 +من خلال تتبعها ل chemotactic material أو source + +239 +00:21:57,680 --> 00:22:02,940 +material اللي تواجنها وبالتالي بتتتبعها + +240 +00:22:07,080 --> 00:22:10,300 +أو الـ Gradient of these materials ايش يعني؟ عليها + +241 +00:22:10,300 --> 00:22:14,940 +زيادة التركيز لان كل ما جربنا على ال Antigen كل ما + +242 +00:22:14,940 --> 00:22:20,600 +زاد تركيز هذه المواد فبصير فيه Chemotaxis وعملية + +243 +00:22:20,600 --> 00:22:25,780 +ال Chemotaxis بتنفيه نيترافيل من خلال أدة بروتينات + +244 +00:22:25,780 --> 00:22:29,860 +هي ال Profile و ال Gelulin + +245 +00:22:40,190 --> 00:22:42,710 +تصفيت الـ Actin موليكيول في الـ Cell Membrane + +246 +00:22:42,710 --> 00:22:49,170 +وبتبدأ الخلية تعمل Crawling لحركتها وبالتالي بتبقى + +247 +00:22:49,170 --> 00:22:56,790 +ماشية لغاية ما تصل إلى الـ Antigen طبعا + +248 +00:22:56,790 --> 00:23:02,050 +هناك بتتمشر وبتبدأ تعمل تتعرف على ال Antigen + +249 +00:23:02,050 --> 00:23:07,270 +وعملية التعرف على ال Antigen بتتم من خلال طريقتين + +250 +00:23:07,270 --> 00:23:14,630 +طريقة الأولانيةإنه في على سطحها pathogen + +251 +00:23:14,630 --> 00:23:20,310 +associated molecular pattern موليكيول وهذه تتعرف + +252 +00:23:20,310 --> 00:23:28,130 +على اللي هو موليكيول + +253 +00:23:28,130 --> 00:23:31,210 +موجودة على سطح اللي هو ال antigen + +254 +00:23:35,220 --> 00:23:39,900 +الـ Neutrophil بيعتبر غالبا عن specific بس ما .. + +255 +00:23:39,900 --> 00:23:45,380 +ما .. ما تتعرف بطريقة أقوى من خلال ال immune + +256 +00:23:45,380 --> 00:23:48,180 +system لإنه في .. بيكون في antibody و في + +257 +00:23:48,180 --> 00:23:52,240 +complement من سابقين ال neutrophil إلى ال antigen + +258 +00:23:52,240 --> 00:23:56,520 +و مسكين فيه و معلمين و عاملين optionized antigen + +259 +00:23:56,520 --> 00:23:59,600 +طبعا هدولة اللي لهم receptor على سطح ال neutrophil + +260 +00:23:59,600 --> 00:24:02,760 +وبالتالي بيصير في ارتباط direct ايش + +261 +00:24:06,170 --> 00:24:10,070 +الانتيجن والانتيبادي والنيتروفيل وبعد ذلك بيصير + +262 +00:24:10,070 --> 00:24:13,650 +فيه phagocytosis وبيتم عملية ال killing وهتجهتح + +263 +00:24:13,650 --> 00:24:19,650 +نشوف كيف بيتم ال killing دي هي الخطوات بالترتيب + +264 +00:24:19,650 --> 00:24:23,950 +لعملية ال phagocytosis طبعا زي ما انتوا شايفين + +265 +00:24:23,950 --> 00:24:27,410 +عبارة عن phagocytic cell على سطحة receptors لان + +266 +00:24:27,410 --> 00:24:31,890 +قولنا ال antigen بيرتبط + +267 +00:24:33,410 --> 00:24:37,170 +بالـ Neutrophil أو هى بتمسك الانتجر من خلال + +268 +00:24:37,170 --> 00:24:42,170 +الريسبتور على سطحها و الريسبتور هذه اللى هى ايضا + +269 +00:24:42,170 --> 00:24:49,270 +لجند على سطح الميكروب Escavenger Receptor FC + +270 +00:24:49,270 --> 00:24:55,190 +Receptor لل IGG ثم Complement Receptor و To Like + +271 +00:24:55,190 --> 00:24:58,950 +Receptor و دى عبارة عن + +272 +00:25:03,250 --> 00:25:07,950 +الـ phagocystic process كما انتوا شايفين نشطة + +273 +00:25:07,950 --> 00:25:11,750 +تعملت pseudo mode أي الميكروب نشطة تعملت pseudo + +274 +00:25:11,750 --> 00:25:16,110 +mode أكلت الميكروب دخل جوا الميكروب و كور حاجة + +275 +00:25:16,110 --> 00:25:18,270 +بيسموها phagosome او + +276 +00:25:20,390 --> 00:25:26,410 +في في phagocystic vesicle وطبعا بعد هي كذا بيصير + +277 +00:25:26,410 --> 00:25:30,470 +في اختلاط معايا ما بين الفاجوزوم والعيزوزوم فبتكون + +278 +00:25:30,470 --> 00:25:33,950 +حاجة باسمها فاجو والعيزوزوم طبعا هالجيتصار ال + +279 +00:25:33,950 --> 00:25:39,130 +granules موجودة وين هي و ال antigen مع بعض فبصير + +280 +00:25:39,130 --> 00:25:41,410 +عملية partially digesting + +281 +00:25:45,070 --> 00:25:55,370 +الميكروبات تقوم بتقطيع الميكروبات وبعد ذلك تقوم + +282 +00:25:55,370 --> 00:25:59,150 +بتقطيع الميكروبات تقوم بتقطيع الميكروبات تقوم + +283 +00:25:59,150 --> 00:26:00,330 +بتقطيع الميكروبات تقوم بتقطيع الميكروبات تقوم + +284 +00:26:00,330 --> 00:26:01,130 +بتقطيع الميكروبات تقوم بتقطيع الميكروبات تقوم + +285 +00:26:01,130 --> 00:26:02,670 +بتقطيع الميكروبات تقوم بتقطيع الميكروبات تقوم + +286 +00:26:02,670 --> 00:26:03,170 +بتقطيع الميكروبات تقطيع الميكروبات تقطيع + +287 +00:26:03,170 --> 00:26:07,010 +الميكروبات تقطيع الميكروبات تقطيع الميكروبات تقطيع + +288 +00:26:07,010 --> 00:26:12,390 +الميكروبات تقطيع الميكروبات تقطيع الميكروبات تقطيع + +289 +00:26:12,390 --> 00:26:12,390 +الميكروبات تقطيع الميكروبات تقطيع الميكروبات تقطيع + +290 +00:26:12,390 --> 00:26:16,720 +الموهذا نوعين، يا إما يدخل الـmylobrexidase في + +291 +00:26:16,720 --> 00:26:21,680 +الموضوع يا إما mylobrexidase independent ونوع تاني + +292 +00:26:21,680 --> 00:26:26,220 +اللي هو ال oxygen independent في ال oxygen + +293 +00:26:26,220 --> 00:26:26,960 +independent + +294 +00:26:29,510 --> 00:26:33,090 +طبعا بيصير في استهلاك للأكسجين بكمية كبيرة جدا و + +295 +00:26:33,090 --> 00:26:37,490 +بتبدأ تتكون سلسلة من التفاعلات الكيميائية محصلة + +296 +00:26:37,490 --> 00:26:41,390 +إنتاجها تكوين ال free radical compound كلنا بنعرف + +297 +00:26:41,390 --> 00:26:44,050 +أن ال free radical compound هي عبارة عن highly + +298 +00:26:44,050 --> 00:26:49,750 +toxic substance تعمل قتل للميكروب وتقطيعه بشكل مهم + +299 +00:26:50,010 --> 00:26:54,490 +قسموها لنوعين ميلوبرقسديز independent بيتكون فيها + +300 +00:26:54,490 --> 00:27:00,010 +القاتي ده هو الخطوات + +301 +00:27:00,010 --> 00:27:06,790 +بيتكون فيها ال super oxide و في الأول بيتكون + +302 +00:27:06,790 --> 00:27:10,270 +hydrogen radical + +303 +00:27:10,270 --> 00:27:17,490 +ثم super oxide اللي بيتفاعل مع ال hydrogen و بيكون + +304 +00:27:17,490 --> 00:27:18,490 +انه hydrogen بال + +305 +00:27:22,490 --> 00:27:26,390 +يتفاعل الهيدروجينبروكسايد مع السوباروكسايد بكونها + +306 +00:27:26,390 --> 00:27:31,530 +هيدروكسيل راديكال كومباونت وزي ما انتوا شايفين كل + +307 +00:27:31,530 --> 00:27:36,230 +المراكبات اللي علمها بالأحمر هي عبارة عن free + +308 +00:27:36,230 --> 00:27:40,970 +radical compound سوباروكسايد هيدروجينبروكسايد ثم + +309 +00:27:40,970 --> 00:27:46,790 +هيدرونيوم ايون وهيدروكسيل راديكال كومباونت في وجود + +310 +00:27:46,790 --> 00:27:51,990 +الميينوبركسديز كانوا الهيدروجينبروكسايد اللي اتكون + +311 +00:27:52,610 --> 00:27:58,010 +تتفاعل مع الكلور ويطلب مني Hypochlorite هذه عبارة + +312 +00:27:58,010 --> 00:28:02,070 +عن مادة عالية توكسيكية اللي تتفاعل في وجود الميه + +313 +00:28:02,070 --> 00:28:09,850 +ويتكون Super Oxide او Hydronium Ion وSuper Oxide + +314 +00:28:09,850 --> 00:28:13,210 +في وجود الميه يطلب مني Hydrogen Peroxide مرة تانية + +315 +00:28:16,070 --> 00:28:20,070 +طبعا الهيدروجين البروسايد في الآخر متخلص عليه منه + +316 +00:28:20,070 --> 00:28:26,270 +من خلال ال catarase enzyme اللي بيحوله لمية و ايضا + +317 +00:28:26,270 --> 00:28:35,270 +oxygen radical compound نوع التاني من ال killing + +318 +00:28:35,270 --> 00:28:37,010 +هو ال oxygen independent + +319 +00:28:40,240 --> 00:28:46,340 +يعني غالبا ضعيف لكن هو وسيلة من وسائل القتل بيعتمد + +320 +00:28:46,340 --> 00:28:50,720 +على ال granules of neutrophil وقولنا في ان + +321 +00:28:50,720 --> 00:28:56,480 +كاتايونك بروتين زي ال cathepsin اللي بيعمل تقطيع + +322 +00:28:56,480 --> 00:29:02,380 +للممرين ال isozyme أيضا بيقطع روابط البروتينيين + +323 +00:29:18,370 --> 00:29:24,870 +أيضاً في ميكانيزم آخر برضه Oxygen Independent ياله + +324 +00:29:24,870 --> 00:29:29,670 +ال Nitric Oxides بس يمسك ال microbeige بال + +325 +00:29:29,670 --> 00:29:35,490 +Receptor تبعه على سطح ال .. ال .. نترافيل وهو يمثل + +326 +00:29:35,490 --> 00:29:38,610 +the cytokine اللي هو ال human necrosis factor + +327 +00:29:38,610 --> 00:29:43,770 +وكمان أيوة، + +328 +00:29:43,770 --> 00:29:47,090 +اللي هو ال receptor على سطح الخلية نفسهااللي + +329 +00:29:47,090 --> 00:29:52,690 +بينشطها وبيجي تطلع الـ Nitric Oxide كمان بتطلع + +330 +00:29:52,690 --> 00:29:57,250 +اللي هو Gamma Interferon اللي أيضًا له Receptor + +331 +00:29:57,250 --> 00:30:02,030 +على سطح الخلية وبيطلع ال Nitric Oxide بكميات كبيرة + +332 +00:30:02,030 --> 00:30:08,670 +وهذا بيصير فيه External Killing في منطقة إياش ال + +333 +00:30:08,670 --> 00:30:14,740 +infectionهناك أشخاص أخرى بشكل مختلف في الـ Killer + +334 +00:30:14,740 --> 00:30:19,600 +Cell منها الـ NKE الـ Natural Killer و الـ Lag + +335 +00:30:19,600 --> 00:30:25,400 +Cell و الـ Killer Cell بتعتمد على الـ Antibody + +336 +00:30:25,400 --> 00:30:27,960 +Dependent Cell Mediated Cytotoxicity اللي أهنا + +337 +00:30:27,960 --> 00:30:34,100 +حنحكيها ثم Activated Macrophage و Eosinophil كلهم + +338 +00:30:34,100 --> 00:30:42,160 +بيقتلوا Foreignand altered self targets أي حد + +339 +00:30:42,160 --> 00:30:50,540 +يتصدى ل self-antigen برضه بتتم عملية قتله انكسل + +340 +00:30:50,540 --> 00:30:55,600 +تعرف عليها يعبرها برضه بيسموها large granular + +341 +00:30:55,600 --> 00:30:59,780 +lymphocytes ويقتل + +342 +00:31:00,920 --> 00:31:04,000 +الـ Infected and Malignant Cell يعني Virally + +343 +00:31:04,000 --> 00:31:08,660 +Infected Cell يعني تتعرض لكل خلية فيها + +344 +00:31:08,660 --> 00:31:13,040 +Intracellular Antigen والـ Malignant Cell نتعرف + +345 +00:31:13,040 --> 00:31:23,020 +عليها من خلال CD56 وCD16 لكن مافي CD3 اللي بيتميز + +346 +00:31:23,020 --> 00:31:26,380 +في الـ lymphocytes لأ نحن نشوف انه + +347 +00:31:29,850 --> 00:31:34,990 +أو ريسبتور للـ FC portion of IgG، بينما الـ 56 + +348 +00:31:34,990 --> 00:31:41,570 +مابنعرفش وظيفته لغاية الآن. Once this cell is + +349 +00:31:41,570 --> 00:31:46,610 +activated by Interleukin-2 and Gamma Interferon، + +350 +00:31:46,610 --> 00:31:51,330 +بتصير هذه التحول الخلية إلى activated killer cell، + +351 +00:31:51,330 --> 00:31:54,770 +lymphocyte activated killer cell. + +352 +00:32:01,440 --> 00:32:10,100 +و ال IL-2 قتل ماشي من خلال إفراز certain enzyme + +353 +00:32:10,100 --> 00:32:17,640 +اللي موجودة في ال granules تبعتها ال + +354 +00:32:17,640 --> 00:32:23,520 +malignant cell و ال virally infected cell طب كيف + +355 +00:32:23,520 --> 00:32:28,120 +أنا أتحكم في وظيفة هذه الخلية ال ankyl cell كانوا + +356 +00:32:28,120 --> 00:32:34,720 +فيها على سطحهاتو ريسبتور واحد اسمه KIR Killing + +357 +00:32:34,720 --> 00:32:41,620 +Inhibitory Receptor واحد اسمه KAR Killing + +358 +00:32:41,620 --> 00:32:50,040 +Activating Receptor الاولاني ال KIR is receptor + +359 +00:32:50,040 --> 00:32:58,920 +for MHC molecule بينما ال KAR + +360 +00:33:01,360 --> 00:33:05,560 +هو عبارة عن Killing Receptor بس يرتبط بالـ Legion + +361 +00:33:05,560 --> 00:33:10,700 +تبعه اللي هو الـ KAL على طول بيصير فيه قتل للخلية + +362 +00:33:10,700 --> 00:33:16,640 +كيف يتم هذا الموضوع ببساطة الخلية المصابة سواء + +363 +00:33:16,640 --> 00:33:20,860 +كانت Malignant Cell أو Virally Infected Cell نسبة + +364 +00:33:20,860 --> 00:33:29,440 +ال MHC Molecule اللي على سطحها بتقل فإذا قلتالخلية + +365 +00:33:29,440 --> 00:33:33,460 +هذه اللي هي ال NK cell الرسبتور اللي على السطح + +366 +00:33:33,460 --> 00:33:37,340 +اللي هو بيسموه killing activating receptor بيجي و + +367 +00:33:37,340 --> 00:33:41,900 +بتطلع الخلية و لايجيش شي مرتبط فيها فمرتبط بال لجن + +368 +00:33:41,900 --> 00:33:47,380 +تبع مين تبع ال killing و بقتل الخلية طب في الوضع + +369 +00:33:47,380 --> 00:33:50,300 +الطبيعي شو اللي بيصير؟ يعني الوضع الطبيعي الخلية + +370 +00:33:50,300 --> 00:33:53,660 +الطبيعية على سطحها MHC molecule بتايتها العالي + +371 +00:33:54,870 --> 00:34:02,350 +وبالتالي أول ما تطبط أو تمسك ال K لان K سلب الخلية + +372 +00:34:02,350 --> 00:34:07,970 +السليمة على طول بمسك ال MHC موليكيول بالرسيبتوري + +373 +00:34:07,970 --> 00:34:11,730 +اللي على سطحها وبالتالي بتعرف أن هذه الخلية خلية + +374 +00:34:11,730 --> 00:34:19,210 +سليمة once يعني incubated بمجرد ما يشغل ال KIR + +375 +00:34:19,210 --> 00:34:24,490 +معناته في وقف لعملية القتليبقى عشان عيدها بمعصرية + +376 +00:34:24,490 --> 00:34:29,030 +مرة تانية عملية الانكس على السطحة دول الceptors + +377 +00:34:29,030 --> 00:34:30,390 +واحد منهم + +378 +00:34:37,650 --> 00:34:41,050 +الخلية السليمة على سطحها MSC مونيكول في الوضع + +379 +00:34:41,050 --> 00:34:47,430 +الطبيعي وبالتالي بمجرد ما تمسك فيها تمسك ال MSC + +380 +00:34:47,430 --> 00:34:51,690 +بال KIR Inhibitory Receptor فبعمل Inhibition + +381 +00:34:51,690 --> 00:34:56,680 +للخلية وبالتالي ببدأ عملية القتلبينما إذا مافيش .. + +382 +00:34:56,680 --> 00:35:00,800 +إذا كان في خدية مصابة مافيش MRC molecule وبالتالي + +383 +00:35:00,800 --> 00:35:09,120 +ال receptor القاتل أو KAR بدي يمسك من legend تبع + +384 +00:35:09,120 --> 00:35:12,520 +القتل وبالتالي بيصير عملية قتل للخدية + +385 +00:35:14,770 --> 00:35:19,090 +الـ Killing Cell أيضًا Killer Cell أيضًا بتلعب دور + +386 +00:35:19,090 --> 00:35:24,950 +كبير من خلال اعتمادها على وجود Antibody على سطح + +387 +00:35:24,950 --> 00:35:30,350 +اللي هو الخلية المصعبة طبعًا إيش جاب ال Antibody + +388 +00:35:30,350 --> 00:35:34,690 +احنا قلنا إنه بس يخش فيه Antigen بيتنشط جهاز + +389 +00:35:34,690 --> 00:35:41,270 +المناع فببدأ يكوّن إيش Antibody لـ Micro + +390 +00:35:44,140 --> 00:35:48,820 +أو الخلية المصابة وبيتي بعلمهالأنه في على سطحها + +391 +00:35:48,820 --> 00:35:53,840 +ايش؟ على سطحها انتيجينات فبيجي بنسيك فيها سواء كان + +392 +00:35:53,840 --> 00:35:58,800 +بده التصنيع ال antibody أو ال already secreted + +393 +00:35:58,800 --> 00:36:03,860 +antibody اللي لما بمسيك فيها بمسيك من خلال ال fab + +394 +00:36:03,860 --> 00:36:07,980 +region اللي بيبقى الفالت اللي بيبقى الفالت اللي هو + +395 +00:36:07,980 --> 00:36:12,520 +ال FC region of antibody اللي ال antibody بيربط مع + +396 +00:36:12,520 --> 00:36:19,450 +ال antigen اللي على سطح الخلية من خلال الانتجن + +397 +00:36:19,450 --> 00:36:25,210 +بايندنج انتجن + +398 +00:36:25,210 --> 00:36:30,470 +بايندنج انتجن بايندنج انتجن بايندنج انتجن بايندنج + +399 +00:36:30,470 --> 00:36:31,030 +انتجن بايندنج انتجن بايندنج انتجن بايندنج انتجن + +400 +00:36:31,030 --> 00:36:31,170 +بايندنج انتجن بايندنج انتجن بايندنج انتجن بايندنج + +401 +00:36:31,170 --> 00:36:31,490 +انتجن بايندنج انتجن بايندنج انتجن بايندنج انتجن + +402 +00:36:31,490 --> 00:36:32,670 +بايندنج انتجن بايندنج انتجن بايندنج انتجن بايندنج + +403 +00:36:32,670 --> 00:36:42,450 +انتجن بايندنج انتجن بايندنج انتجن بايندنج + +404 +00:36:42,450 --> 00:36:42,450 +انتجن + +405 +00:36:46,780 --> 00:36:51,640 +هي morphologically الـ killer cell undefined لكنها + +406 +00:36:51,640 --> 00:36:57,760 +ريسبتر اللي هو الفسيبوجيو YGG وبتتعرف على الخلايا + +407 +00:36:57,760 --> 00:37:04,560 +ال optionized اللي هي coated with antibody و ال + +408 +00:37:04,560 --> 00:37:06,460 +could be enkei cell + +409 +00:37:09,440 --> 00:37:14,260 +طبعاً في هذه الحالة على سطح IGG ريسبتر ل FC + +410 +00:37:14,260 --> 00:37:18,700 +portion of IGG مايكروفيجي نفس الحكاية الذين فيه + +411 +00:37:18,700 --> 00:37:24,480 +تتعرف على ال IG .. ال FC portion of IGE مش IGG + +412 +00:37:24,480 --> 00:37:30,720 +طبعاً في معظم الفجوس ال Excel اللي هي ريسبتر لل FC + +413 +00:37:30,720 --> 00:37:31,940 +portion of IGG + +414 +00:37:38,970 --> 00:37:44,930 +طبعا في summary two-slided في summary للمحاضرة + +415 +00:37:44,930 --> 00:37:52,030 +كلها يوميادي عبارة عن محاضرة دربنا فيها مثال عن ال + +416 +00:37:52,030 --> 00:37:56,350 +cellular part + +417 +00:37:56,350 --> 00:37:59,810 +of innate immunity وهو الفاجوس التكسيل في محاضرة + +418 +00:37:59,810 --> 00:38:04,290 +قادمة ان شاء الله هنتطرق لهيومرا ال part من خلال + +419 +00:38:04,290 --> 00:38:07,910 +شريحنا لل compliment وشكرا + diff --git a/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/bSdSiwHmlaA.srt b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/bSdSiwHmlaA.srt new file mode 100644 index 0000000000000000000000000000000000000000..04f1463d40400762df59eb798546daaef13fe187 --- /dev/null +++ b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/bSdSiwHmlaA.srt @@ -0,0 +1,1679 @@ +1 +00:00:02,450 --> 00:00:06,930 +بسم الله الرحمن الرحيم نلتقي اليوم في محاضرة جديدة + +2 +00:00:06,930 --> 00:00:15,450 +بعنوان Tolerance وسنتطرق في هذه المحاضرة إلى عدة + +3 +00:00:15,450 --> 00:00:21,650 +نقاط إن شاء الله but بداية نتعرف على Definition of + +4 +00:00:21,650 --> 00:00:26,610 +Tolerance. Tolerance is a type of specific + +5 +00:00:26,610 --> 00:00:31,510 +unresponsiveness to an antigen. يدخل Antigen وما + +6 +00:00:31,510 --> 00:00:35,030 +بيصير فيه Immune Response له. Induced by the + +7 +00:00:35,030 --> 00:00:37,790 +exposure of specific lymphocyte to that antigen. + +8 +00:00:37,790 --> 00:00:42,950 +It's induced يعني It's an active process but + +9 +00:00:42,950 --> 00:00:47,650 +response to other antigen normally. يعني أنا بدخل + +10 +00:00:47,650 --> 00:00:54,820 +Antigen معين بعمل بوجه الـ Immune Response لهذا + +11 +00:00:54,820 --> 00:01:00,780 +الـ Antigen فقط. لهذا الـ Antigen فقط. تلرجين هو + +12 +00:01:00,780 --> 00:01:03,200 +الـ Antigen اللي يدفع للـ Tolerance. تلرجين هو الـ Antigen + +13 +00:01:03,200 --> 00:01:05,760 +اللي يدفع للـ Tolerance. تلرجين هو الـ Antigen اللي يدفع + +14 +00:01:05,760 --> 00:01:07,760 +للـ Tolerance. تلرجين هو الـ Antigen اللي يدفع للـ Tolerance + +15 +00:01:07,760 --> 00:01:10,800 +تلرجين هو الـ Antigen اللي يدفع للـ Tolerance. تلرجين هو + +16 +00:01:10,800 --> 00:01:15,520 +الـ Antigen اللي يدفع للـ Tolerance. تلرجين هو الـ Antigen + +17 +00:01:15,520 --> 00:01:16,200 +اللي يدفع للـ Tolerance. تلرجين هو الـ Antigen اللي يدفع + +18 +00:01:16,200 --> 00:01:22,830 +للـ Tolerance. تلرجين هو الـ Antigen اللي يدفع للـ Tolerance لكن لا + +19 +00:01:22,830 --> 00:01:27,750 +نتعامل معاها. Normal individuals are tolerant to + +20 +00:01:27,750 --> 00:01:32,590 +their own antigen. بيسموه Self-tolerance أنه Our + +21 +00:01:32,590 --> 00:01:39,070 +own antigen are tolerized. + +22 +00:01:39,070 --> 00:01:43,710 +Foreign antigen may be administered in a way that + +23 +00:01:43,710 --> 00:01:46,630 +preferentially inhibit immune response by inducing + +24 +00:01:46,630 --> 00:01:49,590 +tolerance in specific lymphocytes. أو بيسموها + +25 +00:01:49,590 --> 00:01:54,010 +Antigen Induction. دخل الـ Antigen أو في نفس الوجه اللي + +26 +00:01:54,010 --> 00:02:00,290 +بعمله is Tolerance. Immunological feature قالوا الـ + +27 +00:02:00,290 --> 00:02:04,330 +process is an Antigen induced and it's an active + +28 +00:02:04,330 --> 00:02:08,930 +process. و زي الـ Immunological memory It's an + +29 +00:02:08,930 --> 00:02:14,970 +Antigen specific. و أيضا It can exist in B cell and + +30 +00:02:14,970 --> 00:02:22,550 +T cell or both. وهي أسهل تدخل وتستمر أكثر في T-cell + +31 +00:02:22,550 --> 00:02:33,730 +من B-cell وبالتالي هذه النقاط مقارنة ما بين الـ + +32 +00:02:33,730 --> 00:02:37,190 +Immunological memory وما بين الـ Tolerance. + +33 +00:02:37,190 --> 00:02:42,190 +Differences of Immunological Tolerance و + +34 +00:02:42,190 --> 00:02:46,310 +Immunodeficiency و Immunosuppression. شو الفرق؟ إن + +35 +00:02:46,310 --> 00:02:49,410 +احنا بنحكي على Tolerance يعني على أنه دخل Antigen + +36 +00:02:49,410 --> 00:02:54,210 +وما اشتغلنا أو ما اشتغل الـ Immune Response فبنتوا + +37 +00:02:54,210 --> 00:02:57,870 +شو الفرق بينها وبين الـ Immunodeficiency أو الـ + +38 +00:02:57,870 --> 00:03:05,590 +Immunosuppression. يعني في الـ Immunodeficiency الـ + +39 +00:03:05,590 --> 00:03:09,170 +production of humor or self-mediated immunity is + +40 +00:03:09,170 --> 00:03:15,370 +not there. وبالتالي ليس محدود لأي Antigen لأن هناك + +41 +00:03:15,370 --> 00:03:19,970 +غياب لواحد أو أكثر من واحد من عناصر الـ Immune + +42 +00:03:19,970 --> 00:03:25,510 +Response. يبقى مافي Immune Response لكن الـ Immune + +43 +00:03:25,510 --> 00:03:31,610 +Response اللي غايب غايب لجميع الـ Antigen فبالتالي + +44 +00:03:31,610 --> 00:03:40,030 +ليس محدود لأي Antigen. ندرج مع الـ Suppression which include physical or + +45 +00:03:40,030 --> 00:03:44,370 +chemical. وبعمل Suppression by using this tool و + +46 +00:03:44,370 --> 00:03:51,410 +برضه هي عبارة عن Non specific to an Antigen. طيب + +47 +00:03:59,170 --> 00:04:03,590 +induction of Immunological Telomeres. In fetal period + +48 +00:04:03,590 --> 00:04:06,790 +and neonate. قالوا أول من حكى في هذا الموضوع هو + +49 +00:04:06,790 --> 00:04:14,190 +الاهنس في 1945 لما وجد أنه في Tolerance ما بين الـ + +50 +00:04:14,190 --> 00:04:21,050 +Antigen of two أو of two Dizygotic twins + +51 +00:04:21,050 --> 00:04:26,650 +Monozygotic twins sorry. Monozygotic twins during + +52 +00:04:26,650 --> 00:04:31,980 +fetal life. هذا اهنس. وهي الاتنين had the same + +53 +00:04:31,980 --> 00:04:37,980 +vascular system. بيسموهم + +54 +00:04:37,980 --> 00:04:44,800 +Dizygotic twin by experiment. Medwar إيجي بعده هو + +55 +00:04:44,800 --> 00:04:50,240 +وجماعته واشتغلوا على Strain. إيش جال؟ جال إذا كان + +56 +00:04:50,240 --> 00:04:56,720 +فيه فرق من Strain A أخد Graft من Strain B. It was + +57 +00:04:56,720 --> 00:05:09,620 +rejected. لكن إذا أخدنا Cells من الـStrain B وحقنها + +58 +00:05:09,620 --> 00:05:16,920 +في + +59 +00:05:16,920 --> 00:05:25,890 +فار After birth على طول. في Strain A لما يكبر لو + +60 +00:05:25,890 --> 00:05:31,550 +أخدنا Strain Engraft من B و حققناها ل A ما بيصيرش + +61 +00:05:31,550 --> 00:05:36,150 +Engraft rejection. لكن لو أخدناها من C و أعطينا + +62 +00:05:36,150 --> 00:05:40,950 +إياها زي ما أنتم شايفين C will Engraft و B will + +63 +00:05:40,950 --> 00:05:46,090 +be rejected. بيسموا هذه Neonatal + +64 +00:05:54,720 --> 00:06:02,420 +Tolerance. كأنها خلايا من الـ Strain A وهو + +65 +00:06:02,420 --> 00:06:08,200 +الـ Unit يعني After birth أخدناها + +66 +00:06:08,200 --> 00:06:13,740 +و حققناها في Strain B و حققناها في Strain A. ولما + +67 +00:06:13,740 --> 00:06:22,040 +كبر أخدنا Graft من + +68 +00:06:22,040 --> 00:06:26,560 +بي بعد 14 يوم صار له Graft rejection + +70 +00:06:29,250 --> 00:06:35,910 +أنا بدون حقن هذي Strain A لحاله أخدنا من Skin أخدنا + +71 +00:06:35,910 --> 00:06:39,510 +Skin Graft من Strain B وحقلناها ل B وحطناها على A + +72 +00:06:39,510 --> 00:06:45,450 +بعد أسبوعين بده Cellular rejection. لكن لو حقنا + +73 +00:06:45,450 --> 00:06:51,730 +خلايا من Strain B في Strain A بعد الولادة مباشرة + +74 +00:06:52,610 --> 00:06:58,510 +ماشي بعد حوالي لما يكون طبعا بعد After six weeks + +75 +00:06:58,510 --> 00:07:03,970 +لو أخدنا اللي هو Skin Graft من بي و حطناها على ايه + +76 +00:07:03,970 --> 00:07:07,990 +مش راح يصير له Rejection. لكن لو عدنا الحكاية من + +77 +00:07:07,990 --> 00:07:14,810 +Strain C ماشي وفي نفس الوقت كنا حقنين خلايا من + +78 +00:07:14,810 --> 00:07:18,810 +Strain Bفبالتالي برضه بيصير فيه Graft rejection + +79 +00:07:18,810 --> 00:07:27,850 +مانعه specific for Graft for the cell that + +80 +00:07:27,850 --> 00:07:35,830 +injected. Antigen and Immunological Tolerance + +81 +00:07:35,830 --> 00:07:41,030 +في الـ Adult كانت بتعتمد على الـ Concentration of + +82 +00:07:41,030 --> 00:07:44,390 +Antigen. وفينا two types of Antigen. Monomer or + +83 +00:07:44,390 --> 00:07:49,450 +Aggregate. الـ Pathway of Antigen is also كيف مخش + +84 +00:07:49,450 --> 00:07:55,690 +الجسم و Feature of Determinant. يعني الصفات الابتوب + +85 +00:07:55,690 --> 00:08:03,620 +هو هل هو Telegenic ابتوب ولا لأ. في اختلاف الـ Antigen + +86 +00:08:03,620 --> 00:08:05,340 +في اختلاف الـ Antigen. في اختلاف الـ Antigen. في اختلاف + +87 +00:08:05,340 --> 00:08:06,480 +الـ Antigen. في اختلاف الـ Antigen. في اختلاف الـ Antigen. في + +88 +00:08:06,480 --> 00:08:07,780 +اختلاف الـ Antigen. في اختلاف الـ Antigen. في اختلاف + +89 +00:08:07,780 --> 00:08:08,740 +الـ Antigen. في اختلاف الـ Antigen. في اختلاف الـ Antigen. في + +90 +00:08:08,740 --> 00:08:09,200 +اختلاف الـ Antigen. في اختلاف الـ Antigen. في اختلاف + +91 +00:08:09,200 --> 00:08:09,220 +الـ Antigen. في اختلاف الـ Antigen. في اختلاف + +92 +00:08:09,220 --> 00:08:13,280 +الـ Antigen. في اختلاف الـ Antigen. في اختلاف الـ Antigen. في + +93 +00:08:13,280 --> 00:08:25,280 +اختلاف الـ Antigen. في اختلا + +94 +00:08:28,910 --> 00:08:33,070 +Response. بس متى يكبر الـ Dose بتلاقي الـ Dose ايه اش + +95 +00:08:33,070 --> 00:08:45,870 +بتلاقي الـ Immune Response زاد. ماشي؟ لكن زي + +96 +00:08:45,870 --> 00:08:52,990 +ما أنتم شايفين أنا منطقة اللي هو Dose وأنا منطقة + +97 +00:08:52,990 --> 00:08:56,890 +اللي هي High Dose صار في Tolerance وأنا من المنطقة + +98 +00:08:56,890 --> 00:09:02,760 +اللي هو الـ Antigen اللي احنا بنعمله Immune Response ده هو + +99 +00:09:02,760 --> 00:09:06,780 +Secondary Immune Response. Faster and bigger. نعمل نفس + +100 +00:09:06,780 --> 00:09:12,620 +اللون يعني نفس الـ Antigen. قالوا الـ Tolerance for T + +101 +00:09:12,620 --> 00:09:21,040 +cell أيا Is easier أكثر واحدة. And even it needs + +102 +00:09:21,040 --> 00:09:26,870 +low amount of Antigen. It lasts more ده يه أكثر من + +103 +00:09:26,870 --> 00:09:33,250 +خمس ... مية وخمسين يوم وضائلة لسه عالية بينما الـ + +104 +00:09:33,250 --> 00:09:41,670 +B-cell الـ …Survival time تبعتها أو الـ Tolerance + +105 +00:09:41,670 --> 00:09:51,990 +ممكن يصل لخمسين يوم. والـ Bomber B-cell ده هي ممكن + +106 +00:09:51,990 --> 00:10:00,530 +تكون أقل حتى من خمسين يوم. العوامل + +107 +00:10:00,530 --> 00:10:04,030 +اللي تؤثر على الـ Tolerance. جال الـ Physical form of + +108 +00:10:04,030 --> 00:10:09,920 +Antigen. الـ Large و Aggregate Complex Molecule + +109 +00:10:09,920 --> 00:10:15,480 +بيصير لها Probably Processed وبالتالي بيتقدم للـ + +110 +00:10:15,480 --> 00:10:22,400 +Antigen Presentation. إذا كان Soluble أو Aggregate Free اللي هو + +111 +00:10:22,400 --> 00:10:31,280 +Simple Small Molecule وبيكون Not Processed. Root of + +112 +00:10:31,280 --> 00:10:35,670 +Injection. إذا دخل Subcutaneous أو Intramuscular + +113 +00:10:35,670 --> 00:10:41,790 +بيصير فيه Resistance أو Tolerance لكن إذا كان صار + +114 +00:10:41,790 --> 00:10:48,210 +في اللي هو إذا + +115 +00:10:48,210 --> 00:10:51,630 +كان Subcutaneous أو Intramuscular بيصير فيه Immune + +116 +00:10:51,630 --> 00:10:54,710 +Response. لكن إذا كان Oral أو Sometimes Intravenous + +117 +00:10:54,710 --> 00:10:59,870 +بيكون مافيش Immune Response. كمان الـ Dose of + +118 +00:10:59,870 --> 00:11:03,490 +Antigen تلعب دور كبير. الـ Optimal Dose هنا ممكن + +119 +00:11:03,490 --> 00:11:07,390 +اشتغل في الفار لكن Very large or very small Dose + +120 +00:11:07,390 --> 00:11:10,570 +ممكن + +121 +00:11:10,570 --> 00:11:12,390 +اشتغل في الفار لكن Very large or very small Dose + +122 +00:11:12,390 --> 00:11:12,450 +ممكن اشتغل في الفار لكن Very large or very + +123 +00:11:12,450 --> 00:11:12,550 +Dose ممكن اشتغل في الفار لكن Very large or very + +124 +00:11:12,550 --> 00:11:15,350 +ممكن اشتغل في الفار ممكن اشتغل في الفار ممكن اشتغل + +125 +00:11:15,350 --> 00:11:17,450 +في الفار ممكن اشتغل في الفار ممكن اشتغل في الفار + +126 +00:11:17,450 --> 00:11:21,490 +ممكن + +127 +00:11:21,490 --> 00:11:23,930 +اشتغل في الفار ممكن اشتغل في الفار ممكن اشتغل في + +128 +00:11:23,930 --> 00:11:24,790 +الفار ممكن اشتغل في الفار ممكن اشتغل في الفار ممكن + +129 +00:11:24,790 --> 00:11:29,410 +اشتغل في الفار ممكن اشتغل في الفار ممكن اشتغل في + +130 +00:11:29,410 --> 00:11:37,610 +الفار ممكن اشتغل طبعا Fully differentiated بيكون + +131 +00:11:37,610 --> 00:11:42,630 +اللي هو Tolerance Immune Response وبيعمل Memory + +132 +00:11:42,630 --> 00:11:47,470 +and Effector cell. لكن الـ Newborn غالبا بيصير فيه + +133 +00:11:47,470 --> 00:11:53,370 +أو Immunologically immature. بيكون فيه لسه بيكون + +134 +00:11:53,370 --> 00:11:59,390 +فيه Tolerance أفضل لإن الجهاز المناعي لسه ماختمل + +135 +00:12:00,020 --> 00:12:04,780 +Differentiation state of cells. الخلايا كبيرة + +136 +00:12:04,780 --> 00:12:10,260 +only Immunological in their nature. بيصير فيها + +137 +00:12:10,260 --> 00:12:17,320 +Immunoresponse. لكن الـ Tolerance بيصير Relative + +138 +00:12:17,320 --> 00:12:23,580 +Undifferentiated B-cell with only IgM أو T-cell in + +139 +00:12:23,580 --> 00:12:24,900 +the Thymic cortex. + +140 +00:12:28,620 --> 00:12:34,600 +هي الـ Host هي الـ Newborn وهي الـ Adult. اندونز + + + +141 +00:12:34,600 --> 00:12:38,640 +of tolerance تخيلوا في كمية قليلة جدا صار في إيش + +142 +00:12:38,640 --> 00:12:43,620 +في tolerance عند الـ newborn وهو برضه لسه قليلا لكن + +143 +00:12:43,620 --> 00:12:50,080 +بياخد مقروقة mechanism + +144 +00:12:50,080 --> 00:12:53,390 +of tolerance هنا يوجد نوعين، يوجد الـ Central + +145 +00:12:53,390 --> 00:12:56,150 +Tolerance ويوجد الـ Peripheral Tolerance الـ + +146 +00:12:56,150 --> 00:12:58,730 +Central Tolerance اللي بيحصل في الـ primary + +147 +00:12:58,730 --> 00:13:02,210 +lymphoid organs وبيحصل في يوم يكون في self + +148 +00:13:02,210 --> 00:13:05,050 +-reactive lymphocyte في الـ primary lymphoid organs + +149 +00:13:05,050 --> 00:13:10,590 +وإن كانت بمرض ارثايمس بيصير فيه إيش اللي هو الـ + +150 +00:13:10,590 --> 00:13:14,530 +central tolerance الـ peripheral tolerance الخلايا + +151 +00:13:14,530 --> 00:13:19,970 +اللي بتهرب اللي بتطلع خطأ من الـ primary lymphoid + +152 +00:13:19,970 --> 00:13:22,290 +organs اللي هو بولمارو أو الثايمس بتطلع الـ + +153 +00:13:22,290 --> 00:13:26,050 +periphery هناك برضه بيصير اللي هي tolerance by + +154 +00:13:26,050 --> 00:13:30,330 +different means اللي هنتكلم إليها إن شاء الله في + +155 +00:13:30,330 --> 00:13:31,030 +المحاضرة + +156 +00:13:34,200 --> 00:13:39,960 +وهذه الصورة بتوضح تماما إنها الـ infolypural carols السلبي + +157 +00:13:39,960 --> 00:13:44,840 +تدين الـ lymphocytes طبعا إن الـ lymphocytes خاصة لمن؟ لـ + +158 +00:13:44,840 --> 00:13:53,600 +self antigen تتفاعل معها لكنها إيه إيه إيه إيه إيه + +159 +00:13:53,600 --> 00:13:55,460 +إيه إيه إيه إيه إيه إيه إيه إيه إيه إيه إيه إيه + +160 +00:13:55,460 --> 00:13:55,940 +إيه إيه إيه إيه إيه إيه إيه إيه إيه إيه إيه إيه + +161 +00:13:55,940 --> 00:13:56,140 +إيه إيه إيه إيه + +162 +00:14:03,070 --> 00:14:06,990 +اللي هي non specific for self-antigen هذا يطلع + +163 +00:14:06,990 --> 00:14:10,470 +تيومة صادف antigen اللي هو الـ specific لها بسبب + +164 +00:14:10,470 --> 00:14:16,070 +clonal proliferation بينما لو هربت خلية من الـ primary + +165 +00:14:16,070 --> 00:14:21,070 +lymphoid organs وطلعت which is auto reactive cell + +166 +00:14:21,070 --> 00:14:27,310 +يعني reactive for self-antigen ماشي هتتفاعل معاها + +167 +00:14:27,310 --> 00:14:37,280 +وبعد فترة هتموت اللي هي داخلة عشان تدافع طبعا كانت + +168 +00:14:37,280 --> 00:14:41,040 +ميكانيزم of Tolerance deletion or energy or + +169 +00:14:41,040 --> 00:14:44,600 +lymphocyte that recognize self-antigen in the + +170 +00:14:44,600 --> 00:14:50,660 +periphery Central tolerance جالوا اللي هو during + +171 +00:14:50,660 --> 00:14:53,400 +maturation of lymphocyte in the thymus + +172 +00:14:53,400 --> 00:15:00,660 +الـ T lymphocyte تتعرض لـ self-antigen وطبعا + +173 +00:15:00,660 --> 00:15:04,690 +في هذه الحالة أي خلية تتمسك في هذا الـ self-antigen + +174 +00:15:04,690 --> 00:15:10,750 +it was deleted by negative selection أيضا + +175 +00:15:10,750 --> 00:15:17,990 +الـ negative selection تحدث في الـ thymus الـ + +176 +00:15:17,990 --> 00:15:21,630 +negative selection اللي حصل في الـ thymus يؤدي إلى + +177 +00:15:21,630 --> 00:15:27,550 +أن الخلية إذا كانت auto-reactive ستحصل على + +178 +00:15:27,550 --> 00:15:31,130 +negative selection + +179 +00:15:33,440 --> 00:15:40,660 +Central Tolerance كما تشاهدون هذا يحدث في الـ antigen + +180 +00:15:40,660 --> 00:15:48,940 +المرتبط بالخلايا الـ هيودنتراتيكسل وهو متقدم للخلايا + +181 +00:15:48,940 --> 00:15:53,300 +الاحتمال ارتباط + +182 +00:15:53,300 --> 00:15:57,480 +cell to cell contact في الـ bone marrow يؤدي إلى الآتي + +183 +00:15:57,480 --> 00:16:06,140 +إما يحدث في apoptosis ماشي لإنه في lack of + +184 +00:16:06,140 --> 00:16:12,420 +costimulation أو بيصير في apoptosis لإنه مرتبط + +185 +00:16:12,420 --> 00:16:17,200 +بالفاز بالـ Fas ligand أو بيصير في clonal + +186 +00:16:17,200 --> 00:16:23,400 +proliferation لإنه أصلا خلية هادية على سطحها كل لأن + +187 +00:16:23,400 --> 00:16:27,520 +هو الآن تقل الـ receptors ويبقى during اكتسبتهم + +188 +00:16:27,520 --> 00:16:32,310 +during maturation وبالتالي الخلايا هذه ممكن سيلها + +189 +00:16:32,310 --> 00:16:38,410 +surviving تطلع من الـ bone marrow كـ mature cell أو + +190 +00:16:38,410 --> 00:16:43,710 +من الـ thymus هذه خلية كما إنها ينطبق على الـ T + +191 +00:16:43,710 --> 00:16:47,490 +ينطبق على الـ B في الـ B في الـ bone marrow ده هو الـ + +192 +00:16:47,490 --> 00:16:52,090 +الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ + +193 +00:16:52,090 --> 00:16:52,890 +الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ + +194 +00:16:52,890 --> 00:16:52,950 +الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ + +195 +00:16:52,950 --> 00:16:53,610 +الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ + +196 +00:16:53,610 --> 00:16:54,150 +الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ الـ + +197 +00:16:54,150 --> 00:16:57,930 +الـ الـ الـ الـ الـ الـ الـ يكون على سطحه ابتوب + +198 +00:16:57,930 --> 00:17:04,670 +multivalent self-antigen ماشي بيسلها apoptosis يعني + +199 +00:17:04,670 --> 00:17:11,190 +إذا اتعرفت الـ IgM على self-antigen في داخل الخلية + +200 +00:17:11,190 --> 00:17:17,210 +أو في داخل الجسم بيعمل allograft وبيعمل apoptosis + +201 +00:17:19,770 --> 00:17:23,410 +من الـ Peripheral Tolerance اللي بيصير فيه Clonal + +202 +00:17:23,410 --> 00:17:26,690 +Deletion و Clonal Ignorance Clonal Deletion إنه + +203 +00:17:26,690 --> 00:17:30,930 +للخلايا بتخش وتتعرف على الـ antigen وتعمل deletion إما + +204 +00:17:30,930 --> 00:17:39,730 +بي Fas Fas Ligand interaction أو إنه بيصير + +205 +00:17:39,730 --> 00:17:43,430 +يعني هذا بيسموه Clonal Deletion أو بيصير Clonal + +206 +00:17:43,430 --> 00:17:47,250 +Ignorance الـ antigen إنه يخش الـ antigen وما يسلقه + +207 +00:17:47,250 --> 00:17:53,330 +response لسببين إما أن الـ antigen كميته قليلة وإما أن + +208 +00:17:53,330 --> 00:17:58,850 +الـ antibody اللي على سطح الـ B lymphocyte هو has + +209 +00:17:58,850 --> 00:18:07,110 +low affinity to to this antigen طبعا + +210 +00:18:07,110 --> 00:18:07,850 +فهذه الحالة + +211 +00:18:10,540 --> 00:18:13,380 +زي ما قلنا هذه الحلقة تحدث في الـ Peripheral لما + +212 +00:18:13,380 --> 00:18:20,620 +Viable Functional Lymphocyte تهرب من الـ Bone + +213 +00:18:20,620 --> 00:18:26,620 +marrow لثة لـ Peripheral Blood Clonal + +214 +00:18:26,620 --> 00:18:33,240 +Energy إنه يحصل في Inactivation Due to a lack of + +215 +00:18:33,240 --> 00:18:43,550 +co-stimulatory signal الإنهارجي هو إن يحصل في فشلة + +216 +00:18:43,550 --> 00:18:49,630 +الخلية لإنهارجي إنهارجي إنهارجي إنهارجي إنهارجي + +217 +00:18:49,630 --> 00:18:50,290 +إنهارجي إنهارجي إنهارجي إنهارجي إنهارجي إنهارجي + +218 +00:18:50,290 --> 00:18:51,170 +إنهارجي إنهارجي إنهارجي إنهارجي إنهارجي إنهارجي + +219 +00:18:51,170 --> 00:18:51,350 +إنهارجي إنهارجي إنهارجي إنهارجي إنهارجي إنهارجي + +220 +00:18:51,350 --> 00:18:51,670 +إنهارجي إنهارجي إنهارجي إنهارجي إنهارجي إنهارجي + +221 +00:18:51,670 --> 00:18:52,130 +إنهارجي إنهارجي إنهارجي إنهارجي إنهارجي إنهارجي + +222 +00:18:52,130 --> 00:18:54,130 +إنهارجي إنهارجي إنهارجي إنهارجي إنهارجي إنهارج + +223 +00:18:58,180 --> 00:19:04,840 +نقطة ثانية طبعا هذا في الوضع + +224 +00:19:04,840 --> 00:19:11,880 +الطبيعي هيك مصير لكن لما يدخل الـ antigen ماشي + +225 +00:19:11,880 --> 00:19:20,980 +مرتبط بالـ B cell for science اللي احتمال إنه إنه + +226 +00:19:20,980 --> 00:19:26,140 +خلية تموت اللي تصدت لهذا الـ antigen لإنه طلع الـ + +227 +00:19:26,140 --> 00:19:32,720 +antigen immunogenic أو إنه يكون هناك anergy يعني + +228 +00:19:32,720 --> 00:19:36,960 +functional unresponsiveness أو apoptosis لنفس الخلية + +229 +00:19:36,960 --> 00:19:40,960 +يعني إيه الخلية؟ بتنوض يا إما بتعمل induction + +230 +00:19:40,960 --> 00:19:46,580 +للـ apoptosis وبالتالي بتنوض غيرها يا إما بده يسيلها + +231 +00:19:46,580 --> 00:19:54,280 +inactivation by anergy طبعا these الـ ignorance زي + +232 +00:19:54,280 --> 00:20:00,290 +ما قلنا بتدخل الـ antigen لكن we ignore it ليش؟ ده لأما + +233 +00:20:00,290 --> 00:20:04,990 +لإنه في له affinity to that antigen أو لإنه تركيزه + +234 +00:20:04,990 --> 00:20:09,970 +قليل جدا فبيصير فيش response لكن ممكن يصير response + +235 +00:20:09,970 --> 00:20:17,430 +لو اتعرضت لـ immunogenic antigen فهي + +236 +00:20:17,430 --> 00:20:21,050 +بتبين إنها اللي هو الـ normal response هي + +237 +00:20:21,050 --> 00:20:26,360 +الارتباطات وهي CD28 مع B7 وهي الـ MHC مرتبط بالـ + +238 +00:20:26,360 --> 00:20:35,300 +Class II MHC وهو لما اتعرض لـ Antigen صار فيه + +239 +00:20:35,300 --> 00:20:42,460 +Clonal Proliferation وصار فيه Death الـ anergy هي + +240 +00:20:42,460 --> 00:20:47,420 +نفس الحكاية لكن ناقص صار بس الـ first signal اللي + +241 +00:20:47,420 --> 00:20:58,810 +هو الـ MHC مقدم الـ Antigen لـ الـ TCR ماشي وبالتالي الـ + +242 +00:20:58,810 --> 00:21:06,510 +TCR sorry وبالتالي antigen is recognized لكن ما + +243 +00:21:06,510 --> 00:21:10,070 +اتكونت costimulatory reaction اللي تدعم عملية + +244 +00:21:10,070 --> 00:21:13,270 +التفاعل أو + +245 +00:21:26,220 --> 00:21:31,860 +CD8786 بيرتبط مباشرة بالـ immunoglobulin على سطح + +246 +00:21:31,860 --> 00:21:39,000 +الخلايا في هذه الحالة الارتباط يتم من خلال + +247 +00:21:39,000 --> 00:21:46,100 +الـ inhibitory cytokine والـ CTLA4 ارتبط في CD28 + +248 +00:21:46,100 --> 00:21:52,280 +اللي موجود على سطح الـ B-Lymphocyte فصار فيه + +249 +00:21:52,280 --> 00:21:57,300 +Anergy يعني الـ anergy ممكن تصير By Inactivation + +250 +00:21:57,300 --> 00:22:02,920 +يعني Inhibition ماشي من خلال CTLA4 أو By Deletion + +251 +00:22:06,050 --> 00:22:11,990 +أي قلولة الـ anergy أيضا صارت لتي الـ lymphocyte قدملها + +252 +00:22:11,990 --> 00:22:18,230 +يعني عرضت لها اللي هي الـ first signal لكن الـ + +253 +00:22:18,230 --> 00:22:23,650 +second signal ما حصلها والسبب في ذلك إنه في + +254 +00:22:23,650 --> 00:22:28,530 +inappropriate اللي هو antigen presentation إيش الـ + +255 +00:22:28,530 --> 00:22:29,510 +antigen من الشجرة + +256 +00:22:40,120 --> 00:22:44,960 +هو يقلن الـ anergy نفس الحكاية للـ B-Lymphocytes يوم + +257 +00:22:44,960 --> 00:22:49,960 +يكون فيه عرض الـ antigen بكميات كبيرة الخلية الـ B + +258 +00:22:49,960 --> 00:22:56,720 +-Lymphocyte أيضا بيصير فيها anergy أو يوم + +259 +00:22:56,720 --> 00:23:02,620 +أي خلية ترتبط بالـ Fas Fas ligand it will induce + +260 +00:23:02,620 --> 00:23:03,500 +apoptosis + +261 +00:23:06,920 --> 00:23:09,820 +طريقة أخرى من طرق الـ suppression in the + +262 +00:23:09,820 --> 00:23:15,540 +peripheral blood وهي باستخدام TS T suppressor cell + +263 +00:23:15,540 --> 00:23:19,040 +طبعا هذه بتعمل suppression لك و it's not specific + +264 +00:23:19,040 --> 00:23:26,440 +أكيد شغلها is not specific لكل T lymphocytes or by + +265 +00:23:26,440 --> 00:23:29,640 +action of cytokine بعد الخلايا بتفرز تتعامل بـ + +266 +00:23:29,640 --> 00:23:32,200 +growth factor beta and IL-10 and these are + +267 +00:23:32,200 --> 00:23:35,720 +inhibitory cytokine بيعملوا inhibition للميو + +268 +00:23:35,720 --> 00:23:40,400 +ريسبونس or hold back in signal transduction ماوصلتش + +269 +00:23:40,400 --> 00:23:44,740 +الـ signal لنكليز عشان يكون فيه اللي هو gene + +270 +00:23:44,740 --> 00:23:48,960 +transcription وبالتالي + +271 +00:23:48,960 --> 00:23:55,020 +translation وبالتالي ما صارش فيه function + +272 +00:23:55,020 --> 00:24:00,560 +immunologically privileged sites في بعض الأماكن لا + +273 +00:24:00,560 --> 00:24:06,820 +يحدث فيها immune response وبالتالي لا بيحدث لها + +274 +00:24:07,650 --> 00:24:13,450 +self antigen ولا لـ foreign antigen ولا لأي حاجة + +275 +00:24:13,450 --> 00:24:18,530 +وهذه الأماكن أشهرها اللي هي الـ cornea of the + +276 +00:24:18,530 --> 00:24:27,170 +heart of the eye و الـ brain و testis + +277 +00:24:27,170 --> 00:24:33,190 +و اللهم صلى الله عليه وسلم وعظمك placenta كل هذه + +278 +00:24:33,190 --> 00:24:40,480 +الأماكن ما يصير فيها immune response هذه صورة تظهر لي + +279 +00:24:40,480 --> 00:24:45,460 +ملخص التولرانس + +280 +00:24:46,800 --> 00:24:49,780 +الأولاني هو عبارة عن normal immune response ده هو + +281 +00:24:49,780 --> 00:24:52,640 +ارتبط واخدت two signals وصار فيه proliferation + +282 +00:24:52,640 --> 00:24:56,700 +differentiation ونشطت اللي هو T lymphocytes + +283 +00:24:56,700 --> 00:25:01,240 +فالتاني شو اللي صار كان صار energy كيف بيصير ال + +284 +00:25:01,240 --> 00:25:04,640 +energy قالوا اما بيصير في lack of costimulation هي + +285 +00:25:04,640 --> 00:25:07,780 +without costimulation يعني without the second + +286 +00:25:07,780 --> 00:25:12,560 +signal كنا بنعرف ان الخلية عشان تتمشط تحتاج الى + +287 +00:25:12,560 --> 00:25:17,710 +two signals وبالتالي الأولى صارت لكن الثانية ما .. + +288 +00:25:17,710 --> 00:25:19,890 +اللي هو الـ Costimulatory Reaction ما صارت + +289 +00:25:19,890 --> 00:25:24,190 +وبالتالي صارت خشت في anergy أو إنه صارت بس من خلال + +290 +00:25:24,190 --> 00:25:29,230 +ارتباط بـInhibitory Receptor هي الـB7 ارتبط + +291 +00:25:29,230 --> 00:25:35,930 +بـCTLA-4 طبعا هذا عامل إيهش برضه Unresponsive أو + +292 +00:25:35,930 --> 00:25:42,860 +By Deletion ده هو ال Fas ارتبط بال Fas Ligand أدى إلى + +293 +00:25:42,860 --> 00:25:49,260 +apoptosis أو أن الـ cytokine mediated suppression + +294 +00:25:49,260 --> 00:25:53,100 +قلنا بعض الخلايا بتفرز inhibitory cytokine اللي + +295 +00:25:53,100 --> 00:25:59,560 +بتعمل inhibition ل IL-2 وبالتالي لا يحدث نشاط + +296 +00:25:59,560 --> 00:26:03,400 +وبالتالي inhibition of proliferation and effector + +297 +00:26:03,400 --> 00:26:08,680 +action زي ما أنتم عارفين هي الخلية تحتاج إلى two + +298 +00:26:08,680 --> 00:26:15,170 +signals بتبعت الأولاني ثم بي سيفر مع CD28 بتبعت + +299 +00:26:15,170 --> 00:26:22,290 +الأولاني وبالتالي ده هو إشارة ثم Signal 2 بدها + +300 +00:26:22,290 --> 00:26:27,530 +تكون برضه تحصل وبتدينا إشارة محصلة هذا الكلام + +301 +00:26:27,530 --> 00:26:33,660 +Activated تيهي البصرهذه عبارة عن اللي هو الـ + +302 +00:26:33,660 --> 00:26:36,680 +Tolerance في غياب الـ Co-Stimulatory Reaction اللي + +303 +00:26:36,680 --> 00:26:42,040 +هو Signal واحد بتصير لكن Signal اتنين is absent + +304 +00:26:42,040 --> 00:26:47,020 +فبيصير Tolerance أو Anergy أو Apoptosis from lack + +305 +00:26:47,020 --> 00:26:51,340 +of Signal لك + +306 +00:26:51,340 --> 00:26:55,120 +of Co-Stimulation can lead to Tolerance أو Anergy + +307 +00:26:55,120 --> 00:27:00,400 +طبعا هي هذا ال normal immune responseهنا مافيش co + +308 +00:27:00,400 --> 00:27:03,640 +-stimulation صار فيه anergy هان فيه ارتباط ب + +309 +00:27:03,640 --> 00:27:08,300 +inhibitory receptor اللي هو CTLA-4 أو Cytotoxic + +310 +00:27:08,300 --> 00:27:12,740 +Lymphocyte Antigen رقم 4 وبالتالي صار في إن ايش + +311 +00:27:12,740 --> 00:27:16,640 +unresponsiveness + +312 +00:27:16,640 --> 00:27:21,500 +أو Anergy regulatory by cytokine هاي آيالتين الـ + +313 +00:27:21,500 --> 00:27:23,420 +Transforming Growth Factor Beta عملت عن + +314 +00:27:23,420 --> 00:27:26,980 +responsiveness to the activation of T lymphocytes + +315 +00:27:26,980 --> 00:27:32,140 +وهذه عبارة عن ال pathways ملخصة ماشية for + +316 +00:27:32,140 --> 00:27:37,100 +peripheral tolerance هذا ال normal وهذه الأولاني + +317 +00:27:37,100 --> 00:27:42,640 +عبارة عن anatomical barriers أو immunological + +318 +00:27:42,640 --> 00:27:47,280 +tolerance دخل الأنتجين بس ما صار فيه لهأو يكون + +319 +00:27:47,280 --> 00:27:50,240 +الأنتجين مرتبط بال Fas بال Fas Ligand أو يكون + +320 +00:27:50,240 --> 00:27:54,360 +الأنتجين مرتبط بال Fas بال Fas Ligand أو يكون + +321 +00:27:54,360 --> 00:27:58,720 +الأنتجين مرتبط بال Fas بال Fas Ligand أو يكون + +322 +00:27:58,720 --> 00:27:59,640 +الأنتجين مرتبط بال Fas بال Fas Ligand أو يكون + +323 +00:27:59,640 --> 00:28:01,260 +الأنتجين مرتبط بال Fas بال Fas Ligand أو يكون + +324 +00:28:01,260 --> 00:28:02,580 +الأنتجين مرتبط بال Fas بال Fas Ligand أو يكون + +325 +00:28:02,580 --> 00:28:05,040 +الأنتجين مرتبط بال Fas Ligand أو يكون الأنتجين مرتبط + +326 +00:28:05,040 --> 00:28:09,280 +بال Fas Ligand أو يكون الأنتجين مرتبط بال Fas Ligand + +327 +00:28:09,280 --> 00:28:15,560 +أو يكون الأنتجين مرتبط بال Fas Ligand أو يكون + +328 +00:28:22,280 --> 00:28:25,860 +طريقة أخرى من الأرض Induction of Tolerance by + +329 +00:28:25,860 --> 00:28:31,780 +Antibody Inhibition by Antibody Feedback شو بتعمل؟ + +330 +00:28:31,780 --> 00:28:35,960 +قالوا بيقعدوا Antibody شو بيعمل؟ بيمسك الـ Antigen + +331 +00:28:35,960 --> 00:28:40,580 +وبالتالي الخلية + +332 +00:28:40,580 --> 00:28:45,480 +اللي ناشطة أو specific for that Antigen will not + +333 +00:28:45,480 --> 00:28:49,120 +encounter that Antigen مش ساعة تقابله يعني وكأننا + +334 +00:28:49,120 --> 00:29:01,180 +بنعمل Neutralization لمين؟للـ Antigen وأنا + +335 +00:29:01,180 --> 00:29:05,380 +أشهر هذه أو الأمثلة على ذلك اللي هو الـ RhD اللي + +336 +00:29:05,380 --> 00:29:10,460 +بنعطيه في حالات الارترو بلاستوسيز في تانيس أو في + +337 +00:29:10,460 --> 00:29:14,500 +حالات الولادة إذا كان في تعارض للأنتجين شو بيعمل + +338 +00:29:14,500 --> 00:29:21,080 +بعمل neutralization لمن؟ للأنتجين وبالتالي بيبطل + +339 +00:29:21,660 --> 00:29:29,140 +يواجه الخلية وينشطها مجرد Inhibitory Receptor قال أن + +340 +00:29:29,140 --> 00:29:32,720 +الـ Inhibitory Receptor على ال B-cell في FC Gamma + +341 +00:29:32,720 --> 00:29:38,300 +Receptor 2 وعلى ال T-cell في Cytotoxic Lymphocyte + +342 +00:29:38,300 --> 00:29:44,640 +Antigen number 4 وعلى ال NK cell في KIR Killer + +343 +00:29:44,640 --> 00:29:48,020 +Inhibitory Receptor اللي هو عبارة عن + +344 +00:29:48,020 --> 00:29:50,460 +Immunoglobulin like Receptor + +345 +00:29:53,100 --> 00:29:56,280 +Anti-Idiotypes and Immune Regulation جعلوا الـ + +346 +00:29:56,280 --> 00:30:00,460 +Anti-Idiotypes وقبل عن Antibody ضد الـFab region of + +347 +00:30:00,460 --> 00:30:04,240 +Antibody وبالتالي بيعمل Blocking لمين؟ + +348 +00:30:04,240 --> 00:30:10,460 +للـFab region وبالتالي بيصير فيه unresponsiveness + +349 +00:30:10,460 --> 00:30:17,280 +بيصير فيه Unresponsiveness أي واحد بيمسك فيه في + +350 +00:30:17,280 --> 00:30:20,640 +ال Fab هاي ال Antibody وهي ال Antibody ال Antibody + +351 +00:30:20,640 --> 00:30:24,900 +هذا ماسك في ال Fab هذه كمان هنا ماسك في ال Fab تاني + +352 +00:30:24,900 --> 00:30:30,940 +وهكذاOral Tolerance يعني ال Oral Tolerance طبعا زي + +353 +00:30:30,940 --> 00:30:33,680 +ما نحن عارفين الأكل بت .. بيخش جوا والأكل مليان + +354 +00:30:33,680 --> 00:30:37,660 +أنتيجينات شو اللي بيصير يعني في خانيتين بتلعب دور + +355 +00:30:37,660 --> 00:30:42,360 +كبير في Tolerance ال Oral Tolerance الـ TR3 و TR1 الـ + +356 +00:30:42,360 --> 00:30:47,450 +TR1 بتلعب دور كبير بإيه؟ بإ اللي هو inducing + +357 +00:30:47,450 --> 00:30:50,390 +inhibitory cytokine أو secreting inhibitory + +358 +00:30:50,390 --> 00:30:55,530 +cytokine T regulatory بتعتمد على كمية ال Antigen + +359 +00:30:55,530 --> 00:31:00,930 +فإذا كان في low Antigen dose بيصير في T regulatory + +360 +00:31:00,930 --> 00:31:06,970 +suppression ماشي by + +361 +00:31:06,970 --> 00:31:11,590 +طبعا ال low dose خلاص بيصير في ارتباط و inhibition + +362 +00:31:12,180 --> 00:31:15,600 +الـ high dose جزء منه يصبح Absorption مباشرة + +363 +00:31:15,600 --> 00:31:21,280 +وبتصير فيه anergy لإنه ما بيصير فيه co-stimulatory + +364 +00:31:21,280 --> 00:31:28,440 +reaction formation ال horror autoimmunity horror + +365 +00:31:28,440 --> 00:31:30,720 +autoimmunity اللي هو حكيتهم بالتلاتة ال Immune + +366 +00:31:30,720 --> 00:31:34,600 +privileged ساعد قلت لكم في بعض الأماكن هذه الأماكن + +367 +00:31:34,600 --> 00:31:41,630 +بيسموها Immune Privileged يعني محصنة مناعيا لأنه ما + +368 +00:31:41,630 --> 00:31:46,510 +بيصير فيها Immune Response أما هذه الأماكن هي ال + +369 +00:31:46,510 --> 00:31:49,130 +eye و ال testis و ال brain و ال ovary و ال + +370 +00:31:49,130 --> 00:31:53,290 +placenta ايش اللي بيصير فيها في هذه الأماكن ممكن + +371 +00:31:53,290 --> 00:31:57,510 +Fas Fas Ligand بلعب دور كبير في ال Immune + +372 +00:31:57,510 --> 00:32:02,190 +Privileged Sites Biological Tolerance و Clinical + +373 +00:32:06,200 --> 00:32:10,960 +in clinical medicine عشان نعمل Immunological + +374 +00:32:10,960 --> 00:32:15,780 +Trials نعملوه عشان نحقق الأهداف التالية نمرة واحد + +375 +00:32:15,780 --> 00:32:20,240 +to prevent the rejection of organ allograft and + +376 +00:32:20,240 --> 00:32:24,020 +xenograft نمرة اتنين to treat autoimmune نمرة + +377 +00:32:24,020 --> 00:32:30,100 +تلاتة to treat allergy أيضا + +378 +00:32:30,100 --> 00:32:43,230 +to treat اللي هو tumor induction of tolerance طبعا + +379 +00:32:43,230 --> 00:32:50,630 +by enhancement of طبعا هذا العكس ماشي عشان أعمل + +380 +00:32:50,630 --> 00:32:57,430 +termination لل Tolerance زي + +381 +00:32:57,430 --> 00:33:01,470 +في حالات اللي هو tumor cell أو في حالات infectious + +382 +00:33:02,610 --> 00:33:06,190 +Infection Disease بعمل Termination لل Tolerance عشان + +383 +00:33:06,190 --> 00:33:10,410 +يكون فيه Good Immune Response وهذه بتحكي على + +384 +00:33:10,410 --> 00:33:14,190 +Clinical Phase زي ما أنتم شايفين هذا المريض صار + +385 +00:33:14,190 --> 00:33:20,290 +عنده Hematoma في هذه المنطقة سموها Hepatic Hematoma أو + +386 +00:33:20,290 --> 00:33:21,450 +Line Hematoma + +387 +00:33:23,670 --> 00:33:27,330 +وش اللي صار تفاصيل هذه الحالة جاله six years old + +388 +00:33:27,330 --> 00:33:30,830 +male طفل عمره ست سنوات اجى على ال emergency room + +389 +00:33:30,830 --> 00:33:35,150 +with unexplained bruising في اندونازيف due to + +390 +00:33:35,150 --> 00:33:41,130 +minor trauma لما دوروا على ال coagulation factor + +391 +00:33:41,130 --> 00:33:45,090 +لجوا Factor 8 level is less than one percent + +392 +00:33:45,090 --> 00:33:50,790 +of normal قال ال patient اعطوه Factor 8 + +393 +00:33:50,790 --> 00:33:56,900 +concentrate وسابوه كانوا حرروه وطلعوه من المستشفى + +394 +00:33:56,900 --> 00:34:13,800 +لكن بعد two weeks رجع ماشي a release + +395 +00:34:13,800 --> 00:34:16,900 +بطلتين in two weeks اه و the same problem مش + +396 +00:34:16,900 --> 00:34:20,820 +الدعوة اعطوه Factor 8 مرة ثانية لكن Factor + +397 +00:34:20,820 --> 00:34:27,080 +8 مش شغال ليش؟ قالوا فيه Anti-Factor 8 + +398 +00:34:27,080 --> 00:34:31,280 +Activity ماهو الدعوة؟ قالوا صار في Lack of + +399 +00:34:31,280 --> 00:34:38,160 +Tolerance Lack of Tolerance الحالة + +400 +00:34:38,160 --> 00:34:43,160 +هذه بتصير ال prevalence فيها من عشرين لثلاثين في + +401 +00:34:43,160 --> 00:34:47,840 +المية من حالات Factor 8 وأقل في Factor 9 شو + +402 +00:34:47,840 --> 00:34:49,940 +بيقعدوا في هذه الحالة؟ قالوا بيقعدوا في Factor 8 + +403 +00:34:49,940 --> 00:34:54,320 +Concentrate أو Recombinant Factor 8 بكميات كبيرة ثم + +404 +00:34:54,320 --> 00:35:02,380 +inhibitors تتطور لتنهيز ال Factor 8 Therapy + +405 +00:35:02,380 --> 00:35:07,640 +أهم علاجات ممكن تعمل Inhibition ل Factor 8 + +406 +00:35:07,640 --> 00:35:15,300 +Antibody قالوا إنك تعطي Porcine Factor 8 + +407 +00:35:15,300 --> 00:35:19,480 +Porcine اللي هو جاي من الخنازير وهذا طبعا لسه + +408 +00:35:19,480 --> 00:35:21,260 +Cross-reactivity + +409 +00:35:24,080 --> 00:35:30,340 +والـ Immunogenicity تبعته أقل من العادي ال Tolerance + +410 +00:35:30,340 --> 00:35:35,340 +فيه High تحقق ال Tolerance بعطاء اللي هو Factor + +411 +00:35:35,340 --> 00:35:42,600 +8 بكميات كبيرة أو إنك تعمل Gene Therapy ايش + +412 +00:35:42,600 --> 00:35:47,460 +الـ Inhibitors اللي ممكن يكون IgG وله أربعة Sub + +413 +00:35:47,460 --> 00:35:52,390 +classes من واحد لأربعة ال Conditional Factor + +414 +00:35:52,390 --> 00:35:56,370 +Deficiency يمكن أن يكون الـ Autoimmune والذي قبل + +415 +00:35:56,370 --> 00:36:02,490 +ذلك أثر على واحد لم يحدث له قبل ذلك يكون الـ + +416 +00:36:02,490 --> 00:36:03,170 +Autoimmune. + +417 +00:36:05,550 --> 00:36:08,410 +It's usually associated with pregnancy, + +418 +00:36:08,610 --> 00:36:12,270 +autoimmunity, malignancy, multi-transfusion. + +419 +00:36:13,090 --> 00:36:18,570 +advanced age وهكذا + +420 +00:36:18,570 --> 00:36:23,830 +انتهينا المحاضرة أرجو أن تكونوا قد استفدتم وشكرا + +Okay, provide the transcript you would like me to proofread. I will carefully review it for typos, grammatical errors, and punctuation issues, ensuring the original Arabic and English are preserved and the meaning and style are intact. I will then return the corrected transcript in the exact same format. diff --git a/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/bSdSiwHmlaA_postprocess.srt b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/bSdSiwHmlaA_postprocess.srt new file mode 100644 index 0000000000000000000000000000000000000000..45cf9e1e2eb229845ff49f4314e9203dae629abc --- /dev/null +++ b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/bSdSiwHmlaA_postprocess.srt @@ -0,0 +1,1680 @@ +1 +00:00:02,450 --> 00:00:06,930 +بسم الله الرحمن الرحيم نلتقي اليوم في محاضرة جديدة + +2 +00:00:06,930 --> 00:00:15,450 +بعنوان tolerance و سنتطرق في هذه المحاضرة إلى عدة + +3 +00:00:15,450 --> 00:00:21,650 +نقاط ان شاء الله but بداية نتعرف على definition of + +4 +00:00:21,650 --> 00:00:26,610 +toleranceTolerance is a type of specific + +5 +00:00:26,610 --> 00:00:31,510 +unresponsiveness to an antigen بيخش انتجن وما + +6 +00:00:31,510 --> 00:00:35,030 +بيصير فيه immune response له Induced by the + +7 +00:00:35,030 --> 00:00:37,790 +exposure of specific lymphocyte to that antigen + +8 +00:00:37,790 --> 00:00:42,950 +it's induced يعني it's an active process but + +9 +00:00:42,950 --> 00:00:47,650 +response to other antigen normally يعني أنا بدخل + +10 +00:00:47,650 --> 00:00:54,820 +انتجن معين بعمل بوجه ال immune response forهذا + +11 +00:00:54,820 --> 00:01:00,780 +الانتيجين فقط لهذا الانتيجين فقط تلرجين هو + +12 +00:01:00,780 --> 00:01:03,200 +الانتيجين اللي يدفع للتلرنس تلرجين هو الانتيجين + +13 +00:01:03,200 --> 00:01:05,760 +اللي يدفع للتلرنس تلرجين هو الانتيجين اللي يدفع + +14 +00:01:05,760 --> 00:01:07,760 +للتلرنس تلرجين هو الانتيجين اللي يدفع للتلرنس + +15 +00:01:07,760 --> 00:01:10,800 +تلرجين هو الانتيجين اللي يدفع للتلرنس تلرجين هو + +16 +00:01:10,800 --> 00:01:15,520 +الانتيجين اللي يدفع للتلرنس تلرجين هو الانتيجين + +17 +00:01:15,520 --> 00:01:16,200 +اللي يدفع للتلرنس تلرجين هو الانتيجين اللي يدفع + +18 +00:01:16,200 --> 00:01:22,830 +للتلرنس تلرجين هو الانتيجين اللي يدفع للتلرلكن لا + +19 +00:01:22,830 --> 00:01:27,750 +تتعامل معاها Normal individuals are tolerant to + +20 +00:01:27,750 --> 00:01:32,590 +their own antigen بيسموه self-tolerance انه our + +21 +00:01:32,590 --> 00:01:39,070 +own antigen are tolerized + +22 +00:01:39,070 --> 00:01:43,710 +Foreign antigen may be administered in a way that + +23 +00:01:43,710 --> 00:01:46,630 +preferentially inhibit immune response by inducing + +24 +00:01:46,630 --> 00:01:49,590 +tolerance in specific lymphocytes او بيسموها + +25 +00:01:49,590 --> 00:01:54,010 +antigen inductionدخل الانتجين او في نفس الوجه اللي + +26 +00:01:54,010 --> 00:02:00,290 +بعمله is tolerance immunological feature قالوا ال + +27 +00:02:00,290 --> 00:02:04,330 +process is an antigen induced and it's an active + +28 +00:02:04,330 --> 00:02:08,930 +process و زي ال immunological memory it's an + +29 +00:02:08,930 --> 00:02:14,970 +antigen specific و أيضا it can exist in B cell and + +30 +00:02:14,970 --> 00:02:22,550 +T cell or bothوهي أسهل تدخل و تستمر أكتر في T-cell + +31 +00:02:22,550 --> 00:02:33,730 +من B-cell وبالتالي هذه النقاط مقارنة ما بين الـ + +32 +00:02:33,730 --> 00:02:37,190 +immunological memory و ما بين ال tolerance + +33 +00:02:37,190 --> 00:02:42,190 +differences of immunological tolerance و + +34 +00:02:42,190 --> 00:02:46,310 +immunodeficiency و immunosuppression شو الفرق؟إن + +35 +00:02:46,310 --> 00:02:49,410 +احنا بنحكي على tolerance يعني على انه دخل انتجين + +36 +00:02:49,410 --> 00:02:54,210 +وما اشتغلنا او ما اشتغل ال immune response فبنتوا + +37 +00:02:54,210 --> 00:02:57,870 +شو الفرق بينها و بين ال immunodeficiency او ال + +38 +00:02:57,870 --> 00:03:05,590 +immunosuppression يعني في ال immunodeficiency ال + +39 +00:03:05,590 --> 00:03:09,170 +production of humor or self-mediated immunity is + +40 +00:03:09,170 --> 00:03:15,370 +not thereوبالتالي ليس محدود لأي انتجين لأن هناك + +41 +00:03:15,370 --> 00:03:19,970 +غياب لواحد أو أكتر من واحد من عناصر الـ immune + +42 +00:03:19,970 --> 00:03:25,510 +response يبقى مافي immune response لكن ال immune + +43 +00:03:25,510 --> 00:03:31,610 +response اللي غايب غايب لجميع الانتجين فبالتالي + +44 +00:03:31,610 --> 00:03:40,030 +ليس محدود لأي انتجيندراج معين او اي اداة من ادوات + +45 +00:03:40,030 --> 00:03:44,370 +اللي هو ال suppression which include physical or + +46 +00:03:44,370 --> 00:03:51,410 +chemical و بعمل suppression by using this tool و + +47 +00:03:51,410 --> 00:03:59,170 +برضه هي عبارة عن non specific to an antigen طيب + +48 +00:03:59,170 --> 00:04:03,590 +induction of immunological telomersIn fetal period + +49 +00:04:03,590 --> 00:04:06,790 +and neonate قالوا أول من حكى في هذا الموضوع هو + +50 +00:04:06,790 --> 00:04:14,190 +الاهنس في 1945 لما وجد انه في tolerance ما بين ال + +51 +00:04:14,190 --> 00:04:21,050 +antigen of two او of two dizygotic twins + +52 +00:04:21,050 --> 00:04:26,650 +monozygotic twins sorry monozygotic twins during + +53 +00:04:26,650 --> 00:04:31,980 +fetal life هذا اهنسوهي الاتنين had the same + +54 +00:04:31,980 --> 00:04:37,980 +vascular system بيسموهم + +55 +00:04:37,980 --> 00:04:44,800 +die zygotic twin by experiment Medwar إيجى بعده هو + +56 +00:04:44,800 --> 00:04:50,240 +وجماعته واشتغلوا على string إيش جال جال إذا كان + +57 +00:04:50,240 --> 00:04:56,720 +فيه فرق من string A أخد graph من string B it was + +58 +00:04:56,720 --> 00:05:09,620 +rejectedلكن إذا أخدنا cells من الـString B وحقنها + +59 +00:05:09,620 --> 00:05:16,920 +في + +60 +00:05:16,920 --> 00:05:25,890 +فارafter birth على طول في أسطرين A لما يكبر لو + +61 +00:05:25,890 --> 00:05:31,550 +أخدنا String Engraft من B و أحققناها ل A ما بيصيرش + +62 +00:05:31,550 --> 00:05:36,150 +Engraft rejection لكن لو أخدناها من C و أعطينا + +63 +00:05:36,150 --> 00:05:40,950 +إياها زي ما انتوا شايفين C will Engraft و B will + +64 +00:05:40,950 --> 00:05:46,090 +be rejected بيسموا هذه نينيتل + +65 +00:05:54,720 --> 00:06:02,420 +tolerance كايها خلايا من الـ Stream A وهو + +66 +00:06:02,420 --> 00:06:08,200 +الـ unit يعني after birth أخدناها + +67 +00:06:08,200 --> 00:06:13,740 +و أحققناها في Stream B و أحققناها في Stream Aو لما + +68 +00:06:13,740 --> 00:06:22,040 +كبر اخدنا graph من + +69 +00:06:22,040 --> 00:06:26,560 +بي بعد 14 يوم صار له graph rejection + +70 +00:06:29,250 --> 00:06:35,910 +أنا بدون حقن هذي strain A لحاله خدنا من skin خدنا + +71 +00:06:35,910 --> 00:06:39,510 +skin graft من strain B وحقلناها ل B وحطناها على A + +72 +00:06:39,510 --> 00:06:45,450 +بعد أسبوعين بده cellular rejection لكن لو حقلنا + +73 +00:06:45,450 --> 00:06:51,730 +خلايا من strain B في strain A بعد الولادة مباشرة + +74 +00:06:52,610 --> 00:06:58,510 +ماشي بعد حوالي لما يكون طبعا بعد after six weeks + +75 +00:06:58,510 --> 00:07:03,970 +لو أخدنا اللي هو skin graft من بي و حطناها على ايه + +76 +00:07:03,970 --> 00:07:07,990 +مش راح يصير له rejection لكن لو عدنا الحكاية من + +77 +00:07:07,990 --> 00:07:14,810 +strain C ماشي و في نفس الوقت كنا حقنين خلايا من + +78 +00:07:14,810 --> 00:07:18,810 +strain Bفبالتالي برضه بيصير فيه ash rejection + +79 +00:07:18,810 --> 00:07:27,850 +مانعه specific for ash for the cell that + +80 +00:07:27,850 --> 00:07:35,830 +injectedantigen and immunological tolerance + +81 +00:07:35,830 --> 00:07:41,030 +في الـ adult كانت بتعتمد على ال concentration of + +82 +00:07:41,030 --> 00:07:44,390 +antigen وفينا two types of antigen monomer or + +83 +00:07:44,390 --> 00:07:49,450 +aggregate ال pathway of antigen is also كي مخش + +84 +00:07:49,450 --> 00:07:55,690 +الجسم وfeature of determinant يعني الصفات الابتوب + +85 +00:07:55,690 --> 00:08:03,620 +هو هل هو teleogenic ابتوب ولا لأفي اختلاف الانتيجن + +86 +00:08:03,620 --> 00:08:05,340 +في اختلاف الانتيجن في اختلاف الانتيجن في اختلاف + +87 +00:08:05,340 --> 00:08:06,480 +الانتيجن في اختلاف الانتيجن في اختلاف الانتيجن في + +88 +00:08:06,480 --> 00:08:07,780 +اختلاف الانتيجن في اختلاف الانتيجن في اختلاف + +89 +00:08:07,780 --> 00:08:08,740 +الانتيجن في اختلاف الانتيجن في اختلاف الانتيجن في + +90 +00:08:08,740 --> 00:08:09,200 +اختلاف الانتيجن في اختلاف الانتيجن في اختلاف + +91 +00:08:09,200 --> 00:08:09,220 +اختلاف الانتيجن في اختلاف الانتيجن في اختلاف + +92 +00:08:09,220 --> 00:08:13,280 +الانتيجن في اختلاف الانتيجن في اختلاف الانتيجن في + +93 +00:08:13,280 --> 00:08:25,280 +اختلاف الانتيجن في اختلا + +94 +00:08:28,910 --> 00:08:33,070 +response بس متى يكبر ال dose بتلاقي ال dose ايه اش + +95 +00:08:33,070 --> 00:08:45,870 +بتلاقي ال immune response زاد ماشي لكن زي + +96 +00:08:45,870 --> 00:08:52,990 +ما انتوا شايفين انا منطقة اللي هو dose وانا منطقة + +97 +00:08:52,990 --> 00:08:56,890 +اللي هي high dose صار في tolerance وانا من المنطقة + +98 +00:08:56,890 --> 00:09:02,760 +اللي هوالانتيجن اللي احنا بنعمله ميرو اسبونس ده هو + +99 +00:09:02,760 --> 00:09:06,780 +secondary ميرو اسبونس faster and bigger نعمل نفس + +100 +00:09:06,780 --> 00:09:12,620 +اللون يعني نفس الانتيجن قالوا ال tolerance for T + +101 +00:09:12,620 --> 00:09:21,040 +cell ايا is easier اكتر واحدة and even it needs + +102 +00:09:21,040 --> 00:09:26,870 +low amount of antigenit lasts more دا يه اكتر من + +103 +00:09:26,870 --> 00:09:33,250 +خمس .. مية و خمسين يوم و ضايلة لسه عالية بينما ال + +104 +00:09:33,250 --> 00:09:41,670 +beesel ال ..survival time تبعتها او ال tolerance + +105 +00:09:41,670 --> 00:09:51,990 +ممكن يصل لخمسين يوم و ال bomber b cell ده هي ممكن + +106 +00:09:51,990 --> 00:10:00,530 +تكون اقل حتى من خمسين يوم العوامل + +107 +00:10:00,530 --> 00:10:04,030 +اللي تؤثر على ال tolerance جال ال physical form of + +108 +00:10:04,030 --> 00:10:09,920 +antigenالـ Large و Aggregate Complex Molecule + +109 +00:10:09,920 --> 00:10:15,480 +بيصير لها Probably Processed وبالتالي بيتقدم للـ + +110 +00:10:15,480 --> 00:10:22,400 +Antigen إذا كان Soluble أو Aggregate Free اللي هو + +111 +00:10:22,400 --> 00:10:31,280 +Simple Small Molecule وبيكون Not Processed Root of + +112 +00:10:31,280 --> 00:10:35,670 +Injectionإذا دخل subcutaneous او Intramuscular + +113 +00:10:35,670 --> 00:10:41,790 +بيصير فيه resistance او tolerance لكن إذا كان صار + +114 +00:10:41,790 --> 00:10:48,210 +في اللي هو إذا + +115 +00:10:48,210 --> 00:10:51,630 +كان subcutaneous او Intramuscular بيصير فيه immune + +116 +00:10:51,630 --> 00:10:54,710 +response لكن إذا كان oral او sometimes intravenous + +117 +00:10:54,710 --> 00:10:59,870 +بيكون مافيش او immune response كمان ال dose of + +118 +00:10:59,870 --> 00:11:03,490 +antigen تلعب دور كبير ال optimal dose هناممكن + +119 +00:11:03,490 --> 00:11:07,390 +اشتغل في الفار لكن very large or very small dose + +120 +00:11:07,390 --> 00:11:10,570 +ممكن + +121 +00:11:10,570 --> 00:11:12,390 +اشتغل في الفار لكن very large or very small dose + +122 +00:11:12,390 --> 00:11:12,450 +ممكن اشتغل في الفار لكن very large or very small + +123 +00:11:12,450 --> 00:11:12,550 +dose ممكن اشتغل في الفار لكن very large or very + +124 +00:11:12,550 --> 00:11:15,350 +ممكن اشتغل في الفار ممكن اشتغل في الفار ممكن اشتغل + +125 +00:11:15,350 --> 00:11:17,450 +في الفار ممكن اشتغل في الفار ممكن اشتغل في الفار + +126 +00:11:17,450 --> 00:11:21,490 +ممكن + +127 +00:11:21,490 --> 00:11:23,930 +اشتغل في الفار ممكن اشتغل في الفار ممكن اشتغل في + +128 +00:11:23,930 --> 00:11:24,790 +الفار ممكن اشتغل في الفار ممكن اشتغل في الفار ممكن + +129 +00:11:24,790 --> 00:11:29,410 +اشتغل في الفار ممكن اشتغل في الفار ممكن اشتغل في + +130 +00:11:29,410 --> 00:11:37,610 +الفار ممكن اشتغطبعا fully differentiated بيكوّن + +131 +00:11:37,610 --> 00:11:42,630 +اللي هو tolerance immune response و بيعمل memory + +132 +00:11:42,630 --> 00:11:47,470 +and effector cell لكن ال newborn غالبا بيصير فيه + +133 +00:11:47,470 --> 00:11:53,370 +او immunologically immature بيكون فيه لسه بيكون + +134 +00:11:53,370 --> 00:11:59,390 +فيه tolerance افضل لإن الجهاز المناعها لسه ماختمل + +135 +00:12:00,020 --> 00:12:04,780 +Differentiation state of cells الخلايا الكبيرة + +136 +00:12:04,780 --> 00:12:10,260 +only immunological in their nature بيصير فيها + +137 +00:12:10,260 --> 00:12:17,320 +immunoresponse لكن ال tolerance بيصير relative + +138 +00:12:17,320 --> 00:12:23,580 +undifferentiated بcell with only IgM أو T cell in + +139 +00:12:23,580 --> 00:12:24,900 +the thymic cortex + +140 +00:12:28,620 --> 00:12:34,600 +هي الـ hostage هي الـ newborn وهي الـ adult اندونز + +141 +00:12:34,600 --> 00:12:38,640 +of tolerance تخيلوا في كمية قليلة جدا صار في ايش + +142 +00:12:38,640 --> 00:12:43,620 +في tolerance عند ال newborn وهو برضه لسه قليلا لكن + +143 +00:12:43,620 --> 00:12:50,080 +بياش مقروقة mechanism + +144 +00:12:50,080 --> 00:12:53,390 +of toleranceهنا يوجد نوعين، يوجد الـ Central + +145 +00:12:53,390 --> 00:12:56,150 +Tolerance و يوجد الـ Peripheral Tolerance الـ + +146 +00:12:56,150 --> 00:12:58,730 +Central Tolerance اللى بيحصل في ال primary + +147 +00:12:58,730 --> 00:13:02,210 +lymphoid organs و بيحصل في يوم يكون في self + +148 +00:13:02,210 --> 00:13:05,050 +-reactive lymphocyte في ال primary lymphoid organs + +149 +00:13:05,050 --> 00:13:10,590 +و ان كانت بمر و ارثايمس بصير فيه إيش اللي هو الـ + +150 +00:13:10,590 --> 00:13:14,530 +central tolerance الـ peripheral tolerance الخلايا + +151 +00:13:14,530 --> 00:13:19,970 +اللي بتهرب اللي بتطلع خطأ من ال primary lymphoid + +152 +00:13:19,970 --> 00:13:22,290 +organs اللي هو بولمارو أو الثايمس بتطلع ال + +153 +00:13:22,290 --> 00:13:26,050 +periphery هناك برضه بصير اللي هي tolerance by + +154 +00:13:26,050 --> 00:13:30,330 +different means اللي هنتفرق إليها إن شاء الله في + +155 +00:13:30,330 --> 00:13:31,030 +المحاضرة + +156 +00:13:34,200 --> 00:13:39,960 +وهذه الصورة بتوضح تماما انها الانفوليبرالكاروسلسلب + +157 +00:13:39,960 --> 00:13:44,840 +تدين الانفوسايتز طبعا ان الانفوسايتز خاصة لمن؟ لـ + +158 +00:13:44,840 --> 00:13:53,600 +self energy تتفاعل معها لكنها ايه ايه ايه ايه ايه + +159 +00:13:53,600 --> 00:13:55,460 +ايه ايه ايه ايه ايه ايه ايه ايه ايه ايه ايه ايه + +160 +00:13:55,460 --> 00:13:55,940 +ايه ايه ايه ايه ايه ايه ايه ايه ايه ايه ايه ايه + +161 +00:13:55,940 --> 00:13:56,140 +ايه ايه ايه ايه + +162 +00:14:03,070 --> 00:14:06,990 +اللي هي non specific for self-antigen هذا يطلع + +163 +00:14:06,990 --> 00:14:10,470 +تيومة صادف antigen اللي هو ال specific لها بسبب + +164 +00:14:10,470 --> 00:14:16,070 +clonal proliferation بينما لو هربت خلية من primary + +165 +00:14:16,070 --> 00:14:21,070 +lymphoid orgasm وطلعت which is auto reactive cell + +166 +00:14:21,070 --> 00:14:27,310 +يعني reactive for self-antigen ماشي هتاتفعل معاها + +167 +00:14:27,310 --> 00:14:37,280 +و بعد فترة هتموتاللي هي داخلة عشان تدافع طبعا كانت + +168 +00:14:37,280 --> 00:14:41,040 +ميكانيزم of Tolerance deletion or energy or + +169 +00:14:41,040 --> 00:14:44,600 +lymphocyte that recognize self-antigen in the + +170 +00:14:44,600 --> 00:14:50,660 +periphery Central tolerance جالو اللي هو during + +171 +00:14:50,660 --> 00:14:53,400 +maturation of lymphocyte in the thymus + +172 +00:14:53,400 --> 00:15:00,660 +التليمفocyte تتعرض لself-antigen وطبعا + +173 +00:15:00,660 --> 00:15:04,690 +في هذا الحالةأي خلية تتمسك في هذا الـ self-antigen + +174 +00:15:04,690 --> 00:15:10,750 +it was deleted by negative selection أيضا + +175 +00:15:10,750 --> 00:15:17,990 +ال negative selection تحدث في الـ thymus ال + +176 +00:15:17,990 --> 00:15:21,630 +negative selection اللي حصل في ال thymus يؤدي إلى + +177 +00:15:21,630 --> 00:15:27,550 +أن الخلية إذا كانت auto-reactive ستحصل على + +178 +00:15:27,550 --> 00:15:31,130 +negative selection + +179 +00:15:33,440 --> 00:15:40,660 +Central Tolerance كما تشاهدون هذا يحدث في الانتجين + +180 +00:15:40,660 --> 00:15:48,940 +المرتبط بالخلايا الهيودنتراتيكسل وهو متقدم للخلايا + +181 +00:15:48,940 --> 00:15:53,300 +الاحتمال ارتباط + +182 +00:15:53,300 --> 00:15:57,480 +cell to cell contact في الولمارو يؤدي الى الاتي + +183 +00:15:57,480 --> 00:16:06,140 +اما يحدث في ابوبتوسيزماشي لإنه في lack of + +184 +00:16:06,140 --> 00:16:12,420 +costimulation او بيصير في apoptosis لإنه مرتبط + +185 +00:16:12,420 --> 00:16:17,200 +بالفاز بالفاز legend او بيصير في clonal + +186 +00:16:17,200 --> 00:16:23,400 +proliferation لإنه اصلا خلية هادى على سطحها كل لإن + +187 +00:16:23,400 --> 00:16:27,520 +هو الان تقل ال receptors ويبقى during اكتسبتهم + +188 +00:16:27,520 --> 00:16:32,310 +during maturation وبالتاليالخلايا هذه ممكن سيلها + +189 +00:16:32,310 --> 00:16:38,410 +surviving تطلع من ال bon marrow ك mature cell او + +190 +00:16:38,410 --> 00:16:43,710 +من ال thymus هذه خلية كما انها ينطبق على ال T + +191 +00:16:43,710 --> 00:16:47,490 +انطبق على ال B في ال B في ال bon marrow ده هو ال + +192 +00:16:47,490 --> 00:16:52,090 +ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال + +193 +00:16:52,090 --> 00:16:52,890 +ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال + +194 +00:16:52,890 --> 00:16:52,950 +ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال + +195 +00:16:52,950 --> 00:16:53,610 +ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال + +196 +00:16:53,610 --> 00:16:54,150 +ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال ال + +197 +00:16:54,150 --> 00:16:57,930 +ال ال ال ال ال ال ال اليكون على سطحه ابتوب + +198 +00:16:57,930 --> 00:17:04,670 +multivalent self-antigen ماشي بسلها ابوبتوسز يعني + +199 +00:17:04,670 --> 00:17:11,190 +إذا اتعرفت ال IGM على self-antigen في داخل الخلية + +200 +00:17:11,190 --> 00:17:17,210 +أو في داخل الجسم بيعمل allograft وبعمل ابوبتوسز + +201 +00:17:19,770 --> 00:17:23,410 +من الـ Preferral Tolerance اللي بيصير فيه Clonal + +202 +00:17:23,410 --> 00:17:26,690 +Deletion و Clonal Ignorance Clonal Deletion إنه + +203 +00:17:26,690 --> 00:17:30,930 +للخلايا بتخش و تتعرف على الانتجن و تعمل دليشن إما + +204 +00:17:30,930 --> 00:17:39,730 +بي فاز فاز لجنت interaction أو إنه بيصير + +205 +00:17:39,730 --> 00:17:43,430 +يعني هذا بيسموه Clonal Deletion أو بيصير Clonal + +206 +00:17:43,430 --> 00:17:47,250 +Ignorance الانتجن انه يخش الانتجن و ما يسلقه + +207 +00:17:47,250 --> 00:17:53,330 +responseلسببين إما أن الانتيجن كميته قليلة وإما أن + +208 +00:17:53,330 --> 00:17:58,850 +ال antibody اللي على سطح ال B lymphocyte هو has + +209 +00:17:58,850 --> 00:18:07,110 +low affinity to to this antigen طبعا + +210 +00:18:07,110 --> 00:18:07,850 +فهذا الحالة + +211 +00:18:10,540 --> 00:18:13,380 +زي ما قلنا هذه الحلقة تحدث في الـ Peripheral لما + +212 +00:18:13,380 --> 00:18:20,620 +Viable Functional Lymphocyte تهرب من الـ Bone + +213 +00:18:20,620 --> 00:18:26,620 +marrow لثة لـ Peripheral Blood Clonal + +214 +00:18:26,620 --> 00:18:33,240 +Energy انه يحصل في Inactivation Due to a lack of + +215 +00:18:33,240 --> 00:18:43,550 +co-stimulatory signalالإنهارجي هو ان يحصل في فشلة + +216 +00:18:43,550 --> 00:18:49,630 +الخلية لانهارجي انهارجي انهارجي انهارجي انهارجي + +217 +00:18:49,630 --> 00:18:50,290 +انهارجي انهارجي انهارجي انهارجي انهارجي انهارجي + +218 +00:18:50,290 --> 00:18:51,170 +انهارجي انهارجي انهارجي انهارجي انهارجي انهارجي + +219 +00:18:51,170 --> 00:18:51,350 +انهارجي انهارجي انهارجي انهارجي انهارجي انهارجي + +220 +00:18:51,350 --> 00:18:51,670 +انهارجي انهارجي انهارجي انهارجي انهارجي انهارجي + +221 +00:18:51,670 --> 00:18:52,130 +انهارجي انهارجي انهارجي انهارجي انهارجي انهارجي + +222 +00:18:52,130 --> 00:18:54,130 +انهارجي انهارجي انهارجي انهارجي انهارجي انهارج + +223 +00:18:58,180 --> 00:19:04,840 +نقطة تانية طبعا هذا في الوضع + +224 +00:19:04,840 --> 00:19:11,880 +الطبيعي هيك مصير لكن لما يدخل ال antigen ماشي + +225 +00:19:11,880 --> 00:19:20,980 +مرتبط بالبيلم for science اللي الاحتمال انه انه + +226 +00:19:20,980 --> 00:19:26,140 +خليك موت اللي تصدت لهذا ال antigen لأنه طلع ال + +227 +00:19:26,140 --> 00:19:32,720 +antigen immunogenicأو انه يكون هناك انرجي يعني + +228 +00:19:32,720 --> 00:19:36,960 +functional unresponsiveness أو أبلتوسز لنفس الخلية + +229 +00:19:36,960 --> 00:19:40,960 +يعني إيه الخلية؟ بتنوض يا إما بتعمل induction + +230 +00:19:40,960 --> 00:19:46,580 +للأبلتوسز وبالتالي بتنوض غيرها يا إما بده يسلها + +231 +00:19:46,580 --> 00:19:54,280 +inactivation by energy طبعا these ال ignorance زي + +232 +00:19:54,280 --> 00:20:00,290 +ما قلنا بتدخل الانتجن لكن we ignore itليش؟ ده لأما + +233 +00:20:00,290 --> 00:20:04,990 +لإنه في له affinity to that antigen أو لإنه تركيزه + +234 +00:20:04,990 --> 00:20:09,970 +قليل جدا فبصير فيش response لكن ممكن يصير response + +235 +00:20:09,970 --> 00:20:17,430 +لو اتعرضت ل immunogenic antigen فهي + +236 +00:20:17,430 --> 00:20:21,050 +بتبين انها اللي هو ال normal response هي + +237 +00:20:21,050 --> 00:20:26,360 +الأرتباطات وهي CD28 مع B7وهي الـ MHC مرتبط بالـ + +238 +00:20:26,360 --> 00:20:35,300 +Class II MHC وهو لما اتعرض لـ Antigen صار فيه + +239 +00:20:35,300 --> 00:20:42,460 +Clonal Proliferation وصار فيه Death ال energy هي + +240 +00:20:42,460 --> 00:20:47,420 +نفس الحكاية لكن ناقص صار بس ال first signal اللي + +241 +00:20:47,420 --> 00:20:58,810 +هو ال MHC مقدم ال Antigen ل ال PCRماشي وبالتالي ال + +242 +00:20:58,810 --> 00:21:06,510 +TCR sorry وبالتالي antigen is recognized لكن ما + +243 +00:21:06,510 --> 00:21:10,070 +اتكونت costimulatory reaction اللى تدعم عملية + +244 +00:21:10,070 --> 00:21:13,270 +التفاعل او + +245 +00:21:26,220 --> 00:21:31,860 +CD8786 بيرتبط مباشرة بالأمينoglobulin على سطح + +246 +00:21:31,860 --> 00:21:39,000 +الخلايا في هذه الحالة الارتباط يتم من خلال + +247 +00:21:39,000 --> 00:21:46,100 +الانهيبوتوري سايتوكاينوالـ CTLA4 ارتبط في CD28 + +248 +00:21:46,100 --> 00:21:52,280 +اللي موجود على سطح الـ B-Lymphocyte فصار فيه + +249 +00:21:52,280 --> 00:21:57,300 +Energy يعني ال Energy ممكن تصير By Inactivation + +250 +00:21:57,300 --> 00:22:02,920 +يعني Inhibition ماشي من خلال CTLA4 او By Deletion + +251 +00:22:06,050 --> 00:22:11,990 +أي قلولة الانرجيا أيضا صارت لتي الانفوسايت قدملها + +252 +00:22:11,990 --> 00:22:18,230 +يعني عرضت لها اللي هي ال first signal لكن ال + +253 +00:22:18,230 --> 00:22:23,650 +second signal ما حصلها والسبب في ذلك انه في + +254 +00:22:23,650 --> 00:22:28,530 +inappropriate اللي هو antigen presentation ايش ال + +255 +00:22:28,530 --> 00:22:29,510 +antigen من الشجرة + +256 +00:22:40,120 --> 00:22:44,960 +هو يقلن الانيرجي نفس الحكاية للـ B-Lymphocytes يوم + +257 +00:22:44,960 --> 00:22:49,960 +يكون فيه صليب الانتجين بكميات كبيرة الخلية الـ B + +258 +00:22:49,960 --> 00:22:56,720 +-Lymphocyte ايضا بيصير فيها انيرجي او يوم + +259 +00:22:56,720 --> 00:23:02,620 +اي خلية ترتبط الفاز بالفاز لجند it will induce + +260 +00:23:02,620 --> 00:23:03,500 +apoptosis + +261 +00:23:06,920 --> 00:23:09,820 +طريقة أخرى من طرق الـ suppression in the + +262 +00:23:09,820 --> 00:23:15,540 +peripheral blood وهي باستخدام TS T suppressor cell + +263 +00:23:15,540 --> 00:23:19,040 +طبعا هذه بتعمل suppression لك و it's not specific + +264 +00:23:19,040 --> 00:23:26,440 +أكيد شغلها is not specific لكل T lymphocytes or by + +265 +00:23:26,440 --> 00:23:29,640 +action of cytokine بعد الخلايا بتفرز تتعامل بـ + +266 +00:23:29,640 --> 00:23:32,200 +growth factor beta and IL-10 and these are + +267 +00:23:32,200 --> 00:23:35,720 +inhibitory cytokine بيعملوا inhibition للميو + +268 +00:23:35,720 --> 00:23:40,400 +ريسبونسor hold back in signal transduction ماوصلتش + +269 +00:23:40,400 --> 00:23:44,740 +ال signal لنكليز عشان يكون فيه اللي هو gene + +270 +00:23:44,740 --> 00:23:48,960 +transcription وبالتالي + +271 +00:23:48,960 --> 00:23:55,020 +translation وبالتالي ماصارش فيه function + +272 +00:23:55,020 --> 00:24:00,560 +immunologically privileged sites في بعض الأماكن لا + +273 +00:24:00,560 --> 00:24:06,820 +يحدث فيها immune response وبالتالي لا بيحدث لها + +274 +00:24:07,650 --> 00:24:13,450 +self antigen ولا لأ foreign antigen ولا لأ حاجة + +275 +00:24:13,450 --> 00:24:18,530 +وهذه الأماكن الأشهرها اللي هي ال cornea of the + +276 +00:24:18,530 --> 00:24:27,170 +heart of the eye و ال brain و testis + +277 +00:24:27,170 --> 00:24:33,190 +و اللهم صلى الله عليه وسلم و عظمك placenta كل هذه + +278 +00:24:33,190 --> 00:24:40,480 +أماكن ما يصير فيها immune responseهذه صورة تظهر لي + +279 +00:24:40,480 --> 00:24:45,460 +ملخص التولرانس + +280 +00:24:46,800 --> 00:24:49,780 +الأولاني هو عبارة عن normal immune response ده هو + +281 +00:24:49,780 --> 00:24:52,640 +ارتبط واخدت two signal وصار فيه proliferation + +282 +00:24:52,640 --> 00:24:56,700 +differentiation ونشطت اللي هو T lymphocytes + +283 +00:24:56,700 --> 00:25:01,240 +فالتاني شو اللي صار كان صار energy كيه بيصير ال + +284 +00:25:01,240 --> 00:25:04,640 +energy قالوا اما بيصير في lack of costimulation هي + +285 +00:25:04,640 --> 00:25:07,780 +without costimulation يعني without the second + +286 +00:25:07,780 --> 00:25:12,560 +signal كنا بنعرف ان هو الخلية عشان تتمشط تحتاج الى + +287 +00:25:12,560 --> 00:25:17,710 +two signalوبالتالي الأولى صارت لكن التانية ما .. + +288 +00:25:17,710 --> 00:25:19,890 +اللي هو الـ Cost-Military-Reaction ما صارت + +289 +00:25:19,890 --> 00:25:24,190 +وبالتالي صارت خشت في عنيري أو إنه صارت بس من خلال + +290 +00:25:24,190 --> 00:25:29,230 +ارتباط بـInhibitory Receptor هي الـB7 ارتبط + +291 +00:25:29,230 --> 00:25:35,930 +بـCTLA4 طبعا هذا عامل إيهش برضه Unresponsible او + +292 +00:25:35,930 --> 00:25:42,860 +By Deletion ده هو الفاز ارتبط بالفاز Legendأدى إلى + +293 +00:25:42,860 --> 00:25:49,260 +apoptosis أو ان الـ cytokine mediated suppression + +294 +00:25:49,260 --> 00:25:53,100 +قلنا بعض الخلايا بتفرز inhibitory cytokine اللي + +295 +00:25:53,100 --> 00:25:59,560 +بتعمل inhibition ل IL-2 وبالتالي لا يحدث نشاط + +296 +00:25:59,560 --> 00:26:03,400 +وبالتالي inhibition of proliferation and effector + +297 +00:26:03,400 --> 00:26:08,680 +action زي ما انتوا عارفين هي الخلية تحتاج إلى two + +298 +00:26:08,680 --> 00:26:15,170 +signalبتبعت الأولاني ثم بي سيفر مع CD 28 بتبعت + +299 +00:26:15,170 --> 00:26:22,290 +الأولاني وبالتالي ده هو إشارة ثم Signal 2 بدها + +300 +00:26:22,290 --> 00:26:27,530 +تكون برضه تحصل وبتدينا إشارة محصلة هذا الكلام + +301 +00:26:27,530 --> 00:26:33,660 +Activated تيهي البصرهذه عبارة عن اللي هو الـ + +302 +00:26:33,660 --> 00:26:36,680 +Tolerance في غياب الـ Co-Stimulatory Reaction اللي + +303 +00:26:36,680 --> 00:26:42,040 +هو Signal واحد بتصير لكن Signal اتنين is absent + +304 +00:26:42,040 --> 00:26:47,020 +فبصير Tolerance او Energy او Apoptosis from lack + +305 +00:26:47,020 --> 00:26:51,340 +of Signal لك + +306 +00:26:51,340 --> 00:26:55,120 +of Co-Stimulation can lead to Tolerance او Energy + +307 +00:26:55,120 --> 00:27:00,400 +طبعا هي هذا ال normal immune responseهنا مافيش co + +308 +00:27:00,400 --> 00:27:03,640 +-stimulation صار فيه energy هان فيه ارتباط ب + +309 +00:27:03,640 --> 00:27:08,300 +inhibitory receptor اللي هو CTLA4 او cytotoxic + +310 +00:27:08,300 --> 00:27:12,740 +lymphocyte antigen رقم 4 وبالتالي صار في ان ايش + +311 +00:27:12,740 --> 00:27:16,640 +unresponsiveness + +312 +00:27:16,640 --> 00:27:21,500 +او energyregulatory by cytokine هاي آيالتين الـ + +313 +00:27:21,500 --> 00:27:23,420 +Transforming Growth Factor Beta عملت عن + +314 +00:27:23,420 --> 00:27:26,980 +responsiveness to the activation of T lymphocyte + +315 +00:27:26,980 --> 00:27:32,140 +وهذه عبارة عن ال pathways ملخصة ماشية for + +316 +00:27:32,140 --> 00:27:37,100 +peripheral tolerance هذا ال normal وهذه الأولاني + +317 +00:27:37,100 --> 00:27:42,640 +عبارة عن anatomical barriers او immunological + +318 +00:27:42,640 --> 00:27:47,280 +tolerance دخل الانتجين بس ما صار فيه لهأو يكون + +319 +00:27:47,280 --> 00:27:50,240 +الانتجين مرتبط بالفاس بالفاس ليجنت أو يكون + +320 +00:27:50,240 --> 00:27:54,360 +الانتجين مرتبط بالفاس بالفاس ليجنت أو يكون + +321 +00:27:54,360 --> 00:27:58,720 +الانتجين مرتبط بالفاس بالفاس ليجنت أو يكون + +322 +00:27:58,720 --> 00:27:59,640 +الانتجين مرتبط بالفاس بالفاس ليجنت أو يكون + +323 +00:27:59,640 --> 00:28:01,260 +الانتجين مرتبط بالفاس بالفاس ليجنت أو يكون + +324 +00:28:01,260 --> 00:28:02,580 +الانتجين مرتبط بالفاس بالفاس ليجنت أو يكون + +325 +00:28:02,580 --> 00:28:05,040 +الانتجين مرتبط بالفاس ليجنت أو يكون الانتجين مرتبط + +326 +00:28:05,040 --> 00:28:09,280 +بالفاس ليجنت أو يكون الانتجين مرتبط بالفاس ليجنت + +327 +00:28:09,280 --> 00:28:15,560 +أو يكون الانتجين مرتبط بالفاس ليجنت أو يكون + +328 +00:28:22,280 --> 00:28:25,860 +فريقة أخرى من الأرض Induction of Tolerance by + +329 +00:28:25,860 --> 00:28:31,780 +Antibody Inhibition by Antibody Feedback شو بتعمل؟ + +330 +00:28:31,780 --> 00:28:35,960 +قالوا بيقعدوا Antibody شو بيعمل؟ بيمسك الـ Antigen + +331 +00:28:35,960 --> 00:28:40,580 +وبالتالي الخلية + +332 +00:28:40,580 --> 00:28:45,480 +اللي ناشطة أو specific for that Antigen will not + +333 +00:28:45,480 --> 00:28:49,120 +encounter that Antigen مش ساعة تقابله يعني وكأننا + +334 +00:28:49,120 --> 00:29:01,180 +بنعمل Neutralization لمين؟للـ Antigen وانا + +335 +00:29:01,180 --> 00:29:05,380 +أشهر هذه او الأمثلة على ذلك اللي هو الـ NTD اللي + +336 +00:29:05,380 --> 00:29:10,460 +بنعطيه في حالات الارترو بلاستوسيز في تانيس او في + +337 +00:29:10,460 --> 00:29:14,500 +حالات المولادة اذا كان في تعارض للانتيجن شو بعمل + +338 +00:29:14,500 --> 00:29:21,080 +بعمل neutralization لمن؟ للانتيجن وبالتالي بيبطل + +339 +00:29:21,660 --> 00:29:29,140 +يواجه الخلية وينشطها مجرد انهيبتري ريسبتور قال ان + +340 +00:29:29,140 --> 00:29:32,720 +الانهيبتري ريسبتور على ال B-cell في FC Gamma + +341 +00:29:32,720 --> 00:29:38,300 +receptor 2 وعلى ال T-cell في cytotoxic lymphocyte + +342 +00:29:38,300 --> 00:29:44,640 +antigen number 4 وعلى ال NK cell في KIR killer + +343 +00:29:44,640 --> 00:29:48,020 +inhibitory receptor اللي هو عبارة عن + +344 +00:29:48,020 --> 00:29:50,460 +immunoglobulin likes receptor + +345 +00:29:53,100 --> 00:29:56,280 +Anti-Idiotypes and Immune Regulation جعلوا الـ + +346 +00:29:56,280 --> 00:30:00,460 +Anti-Idiotypes وقبل عن Antibody ضد الـFabregion of + +347 +00:30:00,460 --> 00:30:04,240 +Antibody وبالتالي بيعمل Plocking لمين؟ + +348 +00:30:04,240 --> 00:30:10,460 +للـFabregionوبالتالي بيصير فيه unresponsiveness + +349 +00:30:10,460 --> 00:30:17,280 +بيصير فيه unresponsiveness أي واحد بيمسك فيه في + +350 +00:30:17,280 --> 00:30:20,640 +الفعب هاي ال antibody وهي ال antibody ال antibody + +351 +00:30:20,640 --> 00:30:24,900 +هذا ماسك في الفعب هذه كمان هنا ماسك في الفعب تاني + +352 +00:30:24,900 --> 00:30:30,940 +و هكذاأورالد توليراس يعني الورالد توليراس طبعا زي + +353 +00:30:30,940 --> 00:30:33,680 +ما احنا عارفين الأكل بت .. بيخش جوا و الأكل مليان + +354 +00:30:33,680 --> 00:30:37,660 +انتيجينات شو اللي بيصير يعني فى خانيتين بتلعب دور + +355 +00:30:37,660 --> 00:30:42,360 +كبير في توليرات الورالد توليراس الـ TR3 و TR1 الـ + +356 +00:30:42,360 --> 00:30:47,450 +TR1 بتلعب دور كبير باي أيش؟ باياللي هو inducing + +357 +00:30:47,450 --> 00:30:50,390 +inhibitory cytokine او secreting inhibitory + +358 +00:30:50,390 --> 00:30:55,530 +cytokine T البرتلاتة بتعتمد على كمية ال antigen + +359 +00:30:55,530 --> 00:31:00,930 +فإذا كان في low antigen dose بيصير في T البرتلاتة + +360 +00:31:00,930 --> 00:31:06,970 +suppress ماشي by + +361 +00:31:06,970 --> 00:31:11,590 +طبعا ال low dose خلاص بيصير في ارتباط و inhibition + +362 +00:31:12,180 --> 00:31:15,600 +الـ high dose جزء منه يصبح absorption مباشرة + +363 +00:31:15,600 --> 00:31:21,280 +وبتصير فيه energy لإنه ما بيصير فيه co-stimulatory + +364 +00:31:21,280 --> 00:31:28,440 +reaction formation ال horror tolerance horror + +365 +00:31:28,440 --> 00:31:30,720 +tolerance اللي هو حكيتهم بالتلاتة ال immune + +366 +00:31:30,720 --> 00:31:34,600 +privileged ساعد قلتلكوا في بعض الأماكن هذه الأماكن + +367 +00:31:34,600 --> 00:31:41,630 +بيسموها immune privileged يعنيمحصنة مناعيا لأنه ما + +368 +00:31:41,630 --> 00:31:46,510 +بيصير فيها immune response اما هذه الأماكن هي ال + +369 +00:31:46,510 --> 00:31:49,130 +eye و ال testis و ال brain و ال ovary و ال + +370 +00:31:49,130 --> 00:31:53,290 +placenta ايش اللي بيصير جاله في هذه الأماكن ممكن + +371 +00:31:53,290 --> 00:31:57,510 +فاز فاز legend بلعب دور كبير في ال immune + +372 +00:31:57,510 --> 00:32:02,190 +privileged sites biological tolerance و clinical + +373 +00:32:06,200 --> 00:32:10,960 +in clinical medicine عشان نعمل immunological + +374 +00:32:10,960 --> 00:32:15,780 +trials نعملوه عشان الحقق الأداف القاتية نمرة واحد + +375 +00:32:15,780 --> 00:32:20,240 +to prevent the rejection of organ allograft and + +376 +00:32:20,240 --> 00:32:24,020 +xenograft نمرة اتنين to treat autoimmune نمرة + +377 +00:32:24,020 --> 00:32:30,100 +تلاتة to treat allergy ايضا + +378 +00:32:30,100 --> 00:32:43,230 +to treatاللي هو tumor induction of tolerance طبعا + +379 +00:32:43,230 --> 00:32:50,630 +by enhancement of طبعا هذا العكس ماشي عشان اعمل + +380 +00:32:50,630 --> 00:32:57,430 +termination لل tolerance زي + +381 +00:32:57,430 --> 00:33:01,470 +في حالات اللي هو tumor cell او في حالات infectious + +382 +00:33:02,610 --> 00:33:06,190 +Infection Disease بعمل Termination للترانس عشان + +383 +00:33:06,190 --> 00:33:10,410 +يكون فيه Good Immune Response وهذه بتحكي على + +384 +00:33:10,410 --> 00:33:14,190 +Clinical Phase زي ما انتوا شايفين هذا المريض صار + +385 +00:33:14,190 --> 00:33:20,290 +عنده Hematoma في هذه المنطقة سموها Hep Hematoma او + +386 +00:33:20,290 --> 00:33:21,450 +Line Hematoma + +387 +00:33:23,670 --> 00:33:27,330 +وش اللي صار تفاصيل هذه الحالة جاله six years old + +388 +00:33:27,330 --> 00:33:30,830 +male طفل عمره ست سنوات اجى على ال emergency room + +389 +00:33:30,830 --> 00:33:35,150 +with unexplained bruising في إندونازيف due to + +390 +00:33:35,150 --> 00:33:41,130 +minor trauma لما دوروا على ال coordination factor + +391 +00:33:41,130 --> 00:33:45,090 +لجوا factor تمانية level is less than one percent + +392 +00:33:45,090 --> 00:33:50,790 +of normal قال ال patient اعطوه factor تمانية + +393 +00:33:50,790 --> 00:33:56,900 +concentrateو سابون كانوا حرروه و طلعوه من المستشفى + +394 +00:33:56,900 --> 00:34:13,800 +لكن بعد two weeks ارجع ماشي ا release + +395 +00:34:13,800 --> 00:34:16,900 +بطلتين in two weeks اه و the same problem مش + +396 +00:34:16,900 --> 00:34:20,820 +الدعوة اعطوه factor تمانية مرة تانية لكن factor + +397 +00:34:20,820 --> 00:34:27,080 +تمانية مش شغالليش؟ قالوا فيه Anti-Factor 8 + +398 +00:34:27,080 --> 00:34:31,280 +Activity ماهو الدعوة؟ قالوا صار في Lack of + +399 +00:34:31,280 --> 00:34:38,160 +Tolerance Lack of Tolerance الحالة + +400 +00:34:38,160 --> 00:34:43,160 +هذه بتصير ال prevalence فيها من عشرين لثلاثين في + +401 +00:34:43,160 --> 00:34:47,840 +المية من حالات Factor 8 وأقل في Factor 9 شو + +402 +00:34:47,840 --> 00:34:49,940 +بيقعدوا في هذه الحالة؟ قالوا بيقعدوا في Factor 8 + +403 +00:34:49,940 --> 00:34:54,320 +Concentrated or Recombined Factor 8 بكميات كبيرةثم + +404 +00:34:54,320 --> 00:35:02,380 +انهيبتورات تتطور لتنهيز الفاكتور تمانية ثيرابي + +405 +00:35:02,380 --> 00:35:07,640 +اهم علاجات ممكن تعمل انهيبشين لفاكتور تمانية + +406 +00:35:07,640 --> 00:35:15,300 +انتيبادي قالوا انك تعطي Porcine فاكتور تمانية + +407 +00:35:15,300 --> 00:35:19,480 +Porcine اللي هو جاي من الخنازير وهذا طبعا لسه + +408 +00:35:19,480 --> 00:35:21,260 +cross reactivity + +409 +00:35:24,080 --> 00:35:30,340 +والـ Immunogenicity تبعته أقل من العادى التوليرانس + +410 +00:35:30,340 --> 00:35:35,340 +فيه high تحقق التوليرانس بعطاء اللى هو factor + +411 +00:35:35,340 --> 00:35:42,600 +تمانية بكميات كبيرة أو انك تعمل gene therapy ايش + +412 +00:35:42,600 --> 00:35:47,460 +ال inhibitors اللى ممكن يكون IGG وله اربعة sub + +413 +00:35:47,460 --> 00:35:52,390 +classes من واحد لاربعةالـ Conditional Factor + +414 +00:35:52,390 --> 00:35:56,370 +Deficiency يمكن أن يكون الـ Autoimmune والذي قبل + +415 +00:35:56,370 --> 00:36:02,490 +ذلك اثر على واحد لم يحدث له قبل ذلك يكون الـ + +416 +00:36:02,490 --> 00:36:03,170 +Autoimmune. + +417 +00:36:05,550 --> 00:36:08,410 +It's usually associated with pregnancy, + +418 +00:36:08,610 --> 00:36:12,270 +autoimmunity, malignancy, multi-transfusion. + +419 +00:36:13,090 --> 00:36:18,570 +advanced age وهكذا + +420 +00:36:18,570 --> 00:36:23,830 +انهينا المحاضرة ارجو ان تكونوا قد استفدتم وشكرا + diff --git a/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/dTsaAa5f6Fw_raw.json b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/dTsaAa5f6Fw_raw.json new file mode 100644 index 0000000000000000000000000000000000000000..db1a05ddbd33fed9295ee55ea67f4ca28fa8b633 --- 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constant gene زى ما شوفنا توى فى ال lighted gene وانما فى تسعة different constant gene انهم التسعة قالوا التسعة مسئولين عن الخمسة isotypes اللى هم imagined IgM و IgA و IgG و IgE و IgD", "tokens": [3224, 3215, 12610, 3714, 43500, 3555, 9566, 9957, 37893, 6156, 7578, 472, 5754, 12186, 30767, 7578, 19446, 13412, 38688, 8315, 33427, 7578, 6156, 7578, 2423, 1442, 292, 12186, 4032, 7649, 15042, 6156, 7578, 6055, 3794, 27884, 819, 5754, 12186, 16472, 16095, 16712, 3794, 27884, 50239, 14407, 16712, 3794, 27884, 47524, 19986, 12610, 9957, 18871, 33962, 2304, 3794, 3660, 307, 19477, 13672, 7578, 8032, 2304, 16590, 19271, 44, 4032, 19271, 32, 4032, 19271, 38, 4032, 19271, 36, 4032, 19271, 35], "avg_logprob": -0.23925781901925802, "compression_ratio": 1.5638297872340425, "no_speech_prob": 0.0, "words": [{"start": 834.42, "end": 834.8, "word": "هدول", "probability": 0.61370849609375}, {"start": 834.8, "end": 835.46, "word": " مرتبطين", "probability": 0.96767578125}, {"start": 835.46, "end": 835.68, 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{"start": 862.96, "end": 863.24, "word": " و", "probability": 0.9921875}, {"start": 863.24, "end": 863.92, "word": " IgD", "probability": 0.834228515625}], "temperature": 1.0}, {"id": 33, "seek": 89088, "start": 864.54, "end": 890.88, "text": "و هناك sub classes و ال sub classes احنا عارفين انه في عندنا اربعة لل IGG و اتنين لل IGA فالتلاتة و اربعة سبعة و اتنين تسعة تسعة differently هذا الاختلاف التاني وهذا زي ما انتوا شايفين هي ال variable", "tokens": [2407, 8032, 1863, 995, 4117, 1422, 5359, 4032, 2423, 1422, 5359, 1975, 5016, 8315, 6225, 9640, 5172, 9957, 16472, 3224, 8978, 43242, 8315, 1975, 25513, 27884, 24976, 26367, 38, 4032, 1975, 2655, 1863, 9957, 24976, 286, 12570, 6156, 6027, 2655, 1211, 9307, 3660, 4032, 1975, 25513, 27884, 8608, 3555, 27884, 4032, 1975, 2655, 1863, 9957, 6055, 3794, 27884, 6055, 3794, 27884, 743, 2276, 23758, 2423, 47283, 2655, 15040, 5172, 16712, 7649, 1829, 37037, 15730, 30767, 1829, 19446, 16472, 2655, 14407, 13412, 995, 33911, 9957, 39896, 2423, 7006], 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ال", "probability": 0.94873046875}, {"start": 1317.29, "end": 1317.79, "word": " system؟", "probability": 0.760498046875}, {"start": 1317.79, "end": 1318.19, "word": " جالب", "probability": 0.8152669270833334}, {"start": 1318.19, "end": 1318.25, "word": " ال", "probability": 0.86572265625}, {"start": 1318.25, "end": 1318.83, "word": " DNA", "probability": 0.5517578125}, {"start": 1318.83, "end": 1320.05, "word": " بيلف", "probability": 0.90771484375}, {"start": 1320.05, "end": 1320.53, "word": " حاله", "probability": 0.91455078125}, {"start": 1320.53, "end": 1320.83, "word": " اما", "probability": 0.82958984375}, {"start": 1320.83, "end": 1321.31, "word": " لفة", "probability": 0.783935546875}, {"start": 1321.31, "end": 1321.43, "word": " و", "probability": 0.8095703125}, {"start": 1321.43, "end": 1321.67, "word": " اما", "probability": 0.7646484375}, {"start": 1321.67, "end": 1322.27, "word": " لفتين", "probability": 0.9683837890625}, {"start": 1322.27, "end": 1325.45, "word": " وبالتالي", "probability": 0.91806640625}, {"start": 1325.45, "end": 1325.97, "word": " بيروح", "probability": 0.73486328125}, {"start": 1325.97, "end": 1326.07, "word": " و", "probability": 0.650390625}, {"start": 1326.07, "end": 1326.27, "word": " بعد", "probability": 0.87451171875}, {"start": 1326.27, "end": 1326.53, "word": " هيك", "probability": 0.708740234375}, {"start": 1326.53, "end": 1326.75, "word": " بيصير", "probability": 0.8143310546875}, {"start": 1326.75, "end": 1326.87, "word": " في", "probability": 0.640625}, {"start": 1326.87, "end": 1327.23, "word": " عملية", "probability": 0.9410807291666666}, {"start": 1327.23, "end": 1327.53, "word": " قطع", "probability": 0.8180338541666666}, {"start": 1327.53, "end": 1328.35, "word": " لللفات", "probability": 0.9152018229166666}], "temperature": 1.0}, {"id": 51, "seek": 134425, "start": 1328.99, "end": 1344.25, "text": "فبتجرب الجينات لبعاد جنب بعيد وبتم عملية اختيارهم مين المسئول عن الجينات هذه اللي هو two gene المسئول عن ال", "tokens": [5172, 3555, 2655, 7435, 25513, 25724, 1829, 8315, 2655, 5296, 3555, 3615, 18513, 10874, 1863, 3555, 45030, 25708, 46599, 39237, 6225, 42213, 10632, 1975, 9778, 31371, 9640, 16095, 3714, 9957, 9673, 3794, 19986, 12610, 18871, 25724, 1829, 8315, 2655, 29538, 13672, 1829, 31439, 732, 12186, 9673, 3794, 19986, 12610, 18871, 2423], "avg_logprob": -0.3194110651428883, "compression_ratio": 1.5798319327731092, "no_speech_prob": 7.748603820800781e-07, "words": [{"start": 1328.99, "end": 1329.69, "word": "فبتجرب", "probability": 0.69814453125}, {"start": 1329.69, "end": 1330.39, "word": " الجينات", "probability": 0.8538818359375}, {"start": 1330.39, "end": 1331.11, "word": " لبعاد", "probability": 0.900634765625}, {"start": 1331.11, "end": 1331.65, "word": " جنب", "probability": 0.8603515625}, {"start": 1331.65, "end": 1332.05, "word": " بعيد", "probability": 0.4425048828125}, {"start": 1332.05, "end": 1332.97, "word": " وبتم", "probability": 0.62109375}, {"start": 1332.97, "end": 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"end": 1360.04, "word": " ما", "probability": 0.9609375}, {"start": 1360.04, "end": 1360.3, "word": " قلنا", "probability": 0.8767903645833334}, {"start": 1360.3, "end": 1361.28, "word": " العلامات", "probability": 0.8670247395833334}, {"start": 1361.28, "end": 1362.54, "word": " بيسموها", "probability": 0.855029296875}, {"start": 1362.54, "end": 1363.96, "word": " RSS", "probability": 0.94140625}, {"start": 1363.96, "end": 1364.22, "word": " اللي", "probability": 0.770751953125}, {"start": 1364.22, "end": 1364.34, "word": " هي", "probability": 0.91748046875}, {"start": 1364.34, "end": 1365.02, "word": " Recombination", "probability": 0.9021809895833334}, {"start": 1365.02, "end": 1365.44, "word": " Signal", "probability": 0.90673828125}, {"start": 1365.44, "end": 1366.14, "word": " Sequence", "probability": 0.980224609375}, {"start": 1366.14, "end": 1366.92, "word": " فهمنا", "probability": 0.9651692708333334}, {"start": 1366.92, "end": 1368.22, "word": " العملية؟", "probability": 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هو ال IGM او ال IGD على السطح الخلية و هذا هي ال order of age of gene expression طيب how can we explain that", "tokens": [6027, 1211, 10721, 11933, 15730, 25961, 2655, 20328, 1211, 5016, 5296, 33456, 16247, 3794, 32277, 16712, 9381, 5172, 36081, 20328, 5016, 4724, 1829, 9381, 13546, 8978, 6225, 8315, 4676, 5021, 4032, 1442, 292, 5021, 23758, 39896, 35288, 4032, 12853, 4032, 41185, 28239, 11296, 10632, 4724, 1829, 9566, 1211, 3615, 6225, 8315, 4676, 5021, 4032, 1442, 292, 5021, 4724, 36081, 3555, 9566, 14407, 20449, 45030, 11242, 4032, 4724, 1829, 30544, 12610, 1829, 13672, 1829, 31439, 2423, 26367, 44, 1975, 2407, 2423, 26367, 35, 15844, 21136, 9566, 5016, 33962, 1211, 10632, 4032, 23758, 39896, 2423, 1668, 295, 3205, 295, 12186, 6114, 23032, 1829, 3555, 577, 393, 321, 2903, 300], "avg_logprob": -0.3237847219462748, "compression_ratio": 1.7035573122529644, "no_speech_prob": 4.172325134277344e-07, "words": [{"start": 1560.46, "end": 1560.8, "word": "اللأ", "probability": 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"probability": 0.936279296875}, {"start": 1604.28, "end": 1604.84, "word": " بدأت", "probability": 0.8052571614583334}, {"start": 1604.84, "end": 1605.72, "word": " تصار", "probability": 0.6938883463541666}, {"start": 1605.72, "end": 1606.54, "word": " انه", "probability": 0.652099609375}, {"start": 1606.54, "end": 1606.98, "word": " ليش", "probability": 0.893798828125}, {"start": 1606.98, "end": 1607.32, "word": " ال", "probability": 0.85400390625}, {"start": 1607.32, "end": 1607.64, "word": " why", "probability": 0.55078125}, {"start": 1607.64, "end": 1607.82, "word": " in", "probability": 0.568359375}, {"start": 1607.82, "end": 1608.02, "word": " an", "probability": 0.349365234375}, {"start": 1608.02, "end": 1608.62, "word": " individual", "probability": 0.9462890625}, {"start": 1608.62, "end": 1608.92, "word": " be", "probability": 0.204345703125}, {"start": 1608.92, "end": 1609.66, "word": " lymphocytes", "probability": 0.9547526041666666}, {"start": 1609.66, "end": 1611.18, "word": " بتنتج", "probability": 0.83984375}, {"start": 1611.18, "end": 1611.62, "word": " لنا", "probability": 0.838134765625}, {"start": 1611.62, "end": 1612.54, "word": " only", "probability": 0.88134765625}, {"start": 1612.54, "end": 1612.98, "word": " one", "probability": 0.9541015625}, {"start": 1612.98, "end": 1613.48, "word": " kind", "probability": 0.91552734375}, {"start": 1613.48, "end": 1613.8, "word": " of", "probability": 0.97314453125}, {"start": 1613.8, "end": 1614.72, "word": " immunoglobulin", "probability": 0.9664306640625}], "temperature": 1.0}, {"id": 62, "seek": 163649, "start": 1616.45, "end": 1636.49, "text": "with one kind of habit chain and one kind of lighted chain يعني بيطلعلي one antibody with lighted chain واحدة و habit chain واحدة ليش و كيف احنا شفنا توى هذا الموضوع الحاجة التانية لما بدوا يحطوا نظرية من زمان و بدوا يفكروا كيف اللي شرحناه توى", "tokens": [11820, 472, 733, 295, 7164, 5021, 293, 472, 733, 295, 1442, 292, 5021, 37495, 22653, 4724, 1829, 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habit", "probability": 0.1868896484375}, {"start": 1617.99, "end": 1618.43, "word": " chain", "probability": 0.8408203125}, {"start": 1618.43, "end": 1618.71, "word": " and", "probability": 0.8515625}, {"start": 1618.71, "end": 1618.97, "word": " one", "probability": 0.91064453125}, {"start": 1618.97, "end": 1619.29, "word": " kind", "probability": 0.89453125}, {"start": 1619.29, "end": 1619.49, "word": " of", "probability": 0.9765625}, {"start": 1619.49, "end": 1619.89, "word": " lighted", "probability": 0.8427734375}, {"start": 1619.89, "end": 1620.11, "word": " chain", "probability": 0.94189453125}, {"start": 1620.11, "end": 1620.65, "word": " يعني", "probability": 0.7005615234375}, {"start": 1620.65, "end": 1621.09, "word": " بيطلعلي", "probability": 0.7727864583333334}, {"start": 1621.09, "end": 1621.27, "word": " one", "probability": 0.87841796875}, {"start": 1621.27, "end": 1621.95, "word": " antibody", "probability": 0.84912109375}, {"start": 1621.95, "end": 1622.85, "word": " 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{"start": 2174.24, "end": 2174.66, "word": " هو", "probability": 0.9912109375}, {"start": 2174.66, "end": 2175.94, "word": " variable", "probability": 0.426025390625}, {"start": 2175.94, "end": 2176.34, "word": " region", "probability": 0.93310546875}, {"start": 2176.34, "end": 2177.02, "word": " مختلفة", "probability": 0.976806640625}], "temperature": 1.0}, {"id": 84, "seek": 220385, "start": 2179.35, "end": 2203.85, "text": "سموها small set of nucleotides may be inserted in search in الهام at the VD وD وDJ junctions طب يمكنني أسئول عن هذه العملية كلها عملية إدخال هذه المجموعة من نيوكليوتايد قالوا في انزايم اسمه terminal deoxynucleotide D لتنفر هذه الانزايم", "tokens": [38251, 2407, 11296, 1359, 992, 295, 14962, 310, 1875, 815, 312, 27992, 294, 3164, 294, 2423, 3224, 10943, 412, 264, 691, 35, 4032, 35, 4032, 35, 41, 8156, 3916, 23032, 3555, 7251, 43020, 22653, 5551, 3794, 19986, 12610, 18871, 29538, 18863, 42213, 10632, 28242, 11296, 6225, 42213, 10632, 11933, 3215, 9778, 6027, 29538, 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2183.17, "word": " inserted", "probability": 0.91162109375}, {"start": 2183.17, "end": 2184.03, "word": " in", "probability": 0.73486328125}, {"start": 2184.03, "end": 2184.39, "word": " search", "probability": 0.27490234375}, {"start": 2184.39, "end": 2184.57, "word": " in", "probability": 0.290283203125}, {"start": 2184.57, "end": 2185.41, "word": " الهام", "probability": 0.34814453125}, {"start": 2185.41, "end": 2186.19, "word": " at", "probability": 0.446533203125}, {"start": 2186.19, "end": 2186.35, "word": " the", "probability": 0.86083984375}, {"start": 2186.35, "end": 2187.23, "word": " VD", "probability": 0.4339599609375}, {"start": 2187.23, "end": 2188.89, "word": " وD", "probability": 0.473388671875}, {"start": 2188.89, "end": 2190.33, "word": " وDJ", "probability": 0.5186360677083334}, {"start": 2190.33, "end": 2191.87, "word": " junctions", "probability": 0.6494140625}, {"start": 2191.87, "end": 2192.53, "word": " طب", "probability": 0.716064453125}, {"start": 2192.53, "end": 2192.85, "word": " يمكنني", "probability": 0.4209798177083333}, {"start": 2192.85, "end": 2193.13, "word": " أسئول", "probability": 0.7733154296875}, {"start": 2193.13, "end": 2193.27, "word": " عن", "probability": 0.70947265625}, {"start": 2193.27, "end": 2193.41, "word": " هذه", "probability": 0.6630859375}, {"start": 2193.41, "end": 2193.81, "word": " العملية", "probability": 0.8873697916666666}, {"start": 2193.81, "end": 2194.45, "word": " كلها", "probability": 0.38629150390625}, {"start": 2194.45, "end": 2194.79, "word": " عملية", "probability": 0.88330078125}, {"start": 2194.79, "end": 2196.13, "word": " إدخال", "probability": 0.87078857421875}, {"start": 2196.13, "end": 2196.59, "word": " هذه", "probability": 0.87939453125}, {"start": 2196.59, "end": 2198.77, "word": " المجموعة", "probability": 0.933984375}, {"start": 2198.77, "end": 2198.89, "word": " من", "probability": 0.95947265625}, {"start": 2198.89, "end": 2199.53, "word": " نيوكليوتايد", "probability": 0.7027435302734375}, {"start": 2199.53, "end": 2199.81, "word": " قالوا", "probability": 0.352325439453125}, {"start": 2199.81, "end": 2199.91, "word": " في", "probability": 0.697265625}, {"start": 2199.91, "end": 2200.33, "word": " انزايم", "probability": 0.614959716796875}, {"start": 2200.33, "end": 2200.75, "word": " اسمه", "probability": 0.8831380208333334}, {"start": 2200.75, "end": 2201.21, "word": " terminal", "probability": 0.6416015625}, {"start": 2201.21, "end": 2202.47, "word": " deoxynucleotide", "probability": 0.9200613839285714}, {"start": 2202.47, "end": 2202.61, "word": " D", "probability": 0.701171875}, {"start": 2202.61, "end": 2203.17, "word": " لتنفر", "probability": 0.4248779296875}, {"start": 2203.17, "end": 2203.37, "word": " هذه", "probability": 0.185546875}, {"start": 2203.37, "end": 2203.85, "word": " الانزايم", "probability": 0.848583984375}], "temperature": 1.0}, {"id": 85, "seek": 222380, "start": 2212.54, "end": 2223.8, "text": "وهذا سيضيف إضافة في الاختلافات التي تحدث في كل مرة.الحاجة التانية يقولنا إنه يحدث في P one region nucleotide alteration", "tokens": [2407, 3224, 15730, 8608, 1829, 11242, 33911, 11933, 11242, 31845, 3660, 8978, 2423, 47283, 2655, 15040, 5172, 9307, 38392, 6055, 24401, 12984, 8978, 28242, 3714, 25720, 13, 6027, 5016, 26108, 3660, 16712, 7649, 10632, 7251, 39648, 8315, 36145, 3224, 7251, 24401, 12984, 8978, 430, 472, 4458, 14962, 310, 482, 11337, 399], "avg_logprob": -0.37469953069320094, "compression_ratio": 1.296551724137931, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 2212.5399999999995, "end": 2213.3399999999997, "word": "وهذا", "probability": 0.65625}, {"start": 2213.3399999999997, "end": 2214.14, "word": " سيضيف", "probability": 0.6470947265625}, {"start": 2214.14, "end": 2214.98, "word": " إضافة", "probability": 0.9013671875}, {"start": 2214.98, "end": 2215.28, "word": " في", "probability": 0.09832763671875}, {"start": 2215.28, "end": 2216.72, "word": " الاختلافات", "probability": 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2273.91, "end": 2274.57, "word": "-Nucleotide", "probability": 0.9817708333333334}, {"start": 2274.57, "end": 2274.93, "word": " وبرضه", "probability": 0.8370361328125}, {"start": 2274.93, "end": 2275.49, "word": " المنظم", "probability": 0.76031494140625}, {"start": 2275.49, "end": 2276.03, "word": " المسئول", "probability": 0.74371337890625}, {"start": 2276.03, "end": 2276.45, "word": " عنها", "probability": 0.991943359375}, {"start": 2276.45, "end": 2277.01, "word": " هو", "probability": 0.84326171875}, {"start": 2277.01, "end": 2277.13, "word": " ال", "probability": 0.69091796875}, {"start": 2277.13, "end": 2277.47, "word": " terminal", "probability": 0.75830078125}, {"start": 2277.47, "end": 2279.55, "word": " deoxynucleotide", "probability": 0.7939017159598214}], "temperature": 1.0}, {"id": 88, "seek": 230835, "start": 2281.11, "end": 2308.35, "text": "وهذا الانزيم موجود في الانفوسايت وانهي الانفوسايت الامتور الانفوسايت اللي هو اثناء عملية التصفير والقطع يعني يوم ما تصير ماتشور التيل اللي اللي اللي الانفوسايت بدل الانزيم هذا لأ بدلش الانزيمة since these spaces are random و العملية عملية randomly ال amino acid sequence اللي بيطلع من هذه العملية برضه random", "tokens": [2407, 3224, 15730, 2423, 7649, 11622, 32640, 3714, 29245, 23328, 8978, 2423, 7649, 5172, 41779, 995, 36081, 4032, 7649, 3224, 1829, 2423, 7649, 5172, 41779, 995, 36081, 2423, 10943, 2655, 13063, 2423, 7649, 5172, 41779, 995, 36081, 13672, 1829, 31439, 1975, 12984, 1863, 16606, 6225, 42213, 10632, 16712, 9381, 5172, 13546, 16070, 47432, 3615, 37495, 22653, 7251, 20498, 19446, 6055, 9381, 13546, 3714, 9307, 8592, 13063, 16712, 26895, 13672, 1829, 13672, 1829, 13672, 1829, 2423, 7649, 5172, 41779, 995, 36081, 47525, 1211, 2423, 7649, 11622, 32640, 23758, 5296, 10721, 47525, 1211, 8592, 2423, 7649, 11622, 32640, 3660, 1670, 613, 7673, 366, 4974, 4032, 18863, 42213, 10632, 6225, 42213, 10632, 16979, 2423, 24674, 8258, 8310, 13672, 1829, 4724, 1829, 9566, 1211, 3615, 9154, 29538, 18863, 42213, 10632, 4724, 43042, 3224, 4974], "avg_logprob": -0.360448487842356, "compression_ratio": 2.1074380165289255, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 2281.11, "end": 2281.53, "word": "وهذا", "probability": 0.584228515625}, {"start": 2281.53, "end": 2281.99, "word": " الانزيم", "probability": 0.6153564453125}, {"start": 2281.99, "end": 2282.41, "word": " موجود", "probability": 0.6359049479166666}, {"start": 2282.41, "end": 2283.49, "word": " في", "probability": 0.48583984375}, {"start": 2283.49, "end": 2284.89, "word": " الانفوسايت", "probability": 0.6208902994791666}, {"start": 2284.89, "end": 2287.99, "word": " وانهي", "probability": 0.458343505859375}, {"start": 2287.99, "end": 2288.61, "word": " الانفوسايت", "probability": 0.8664143880208334}, {"start": 2288.61, "end": 2289.75, "word": " الامتور", "probability": 0.342315673828125}, {"start": 2289.75, "end": 2290.35, "word": " الانفوسايت", "probability": 0.7927652994791666}, {"start": 2290.35, "end": 2290.51, "word": " اللي", "probability": 0.68603515625}, {"start": 2290.51, "end": 2290.73, "word": " هو", "probability": 0.8837890625}, {"start": 2290.73, "end": 2291.07, "word": " اثناء", "probability": 0.79217529296875}, {"start": 2291.07, "end": 2291.43, "word": " عملية", "probability": 0.98046875}, {"start": 2291.43, "end": 2292.03, "word": " التصفير", "probability": 0.7557373046875}, {"start": 2292.03, "end": 2292.55, "word": " والقطع", "probability": 0.7132161458333334}, {"start": 2292.55, "end": 2293.11, "word": " يعني", "probability": 0.891357421875}, {"start": 2293.11, "end": 2293.35, "word": " يوم", "probability": 0.960693359375}, {"start": 2293.35, "end": 2293.47, "word": " ما", "probability": 0.332763671875}, {"start": 2293.47, "end": 2293.69, "word": " تصير", "probability": 0.9637044270833334}, {"start": 2293.69, "end": 2294.15, "word": " ماتشور", "probability": 0.5732421875}, {"start": 2294.15, "end": 2294.53, "word": " التيل", "probability": 0.3258056640625}, {"start": 2294.53, "end": 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{"start": 2300.91, "end": 2301.41, "word": " spaces", "probability": 0.64501953125}, {"start": 2301.41, "end": 2301.71, "word": " are", "probability": 0.94775390625}, {"start": 2301.71, "end": 2302.15, "word": " random", "probability": 0.7548828125}, {"start": 2302.15, "end": 2302.39, "word": " و", "probability": 0.68896484375}, {"start": 2302.39, "end": 2302.79, "word": " العملية", "probability": 0.9075520833333334}, {"start": 2302.79, "end": 2303.19, "word": " عملية", "probability": 0.97900390625}, {"start": 2303.19, "end": 2304.13, "word": " randomly", "probability": 0.31884765625}, {"start": 2304.13, "end": 2304.77, "word": " ال", "probability": 0.578125}, {"start": 2304.77, "end": 2304.97, "word": " amino", "probability": 0.84033203125}, {"start": 2304.97, "end": 2305.27, "word": " acid", "probability": 0.9306640625}, {"start": 2305.27, "end": 2305.83, "word": " sequence", "probability": 0.90576171875}, {"start": 2305.83, "end": 2306.03, "word": " اللي", "probability": 0.9609375}, {"start": 2306.03, "end": 2306.61, "word": " بيطلع", "probability": 0.9029296875}, {"start": 2306.61, "end": 2307.11, "word": " من", "probability": 0.97998046875}, {"start": 2307.11, "end": 2307.31, "word": " هذه", "probability": 0.95263671875}, {"start": 2307.31, "end": 2307.75, "word": " العملية", "probability": 0.9930013020833334}, {"start": 2307.75, "end": 2308.07, "word": " برضه", "probability": 0.9345703125}, {"start": 2308.07, "end": 2308.35, "word": " random", "probability": 0.7861328125}], "temperature": 1.0}, {"id": 89, "seek": 233927, "start": 2310.17, "end": 2339.27, "text": "و هدا هي كما قلنا الـ cogeneration of N region insertion هي اسمها عملية القطع ماشي هي ده في الأول بروح و في التاني TDD adds nucleotide فهي يضعف و صارت nucleotide طبعا ligation و يكوّن لي في النهاية اللي هو ال DNA بعد ما نقطع ال entrance اللي هو اللي بعيد بينهم", "tokens": [2407, 8032, 28259, 39896, 9122, 15042, 12174, 1211, 8315, 2423, 39184, 598, 30372, 295, 426, 4458, 8969, 313, 39896, 24525, 2304, 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"word": " chain", "probability": 0.9248046875}, {"start": 2989.44, "end": 2990.6, "word": " فالتصفيتة", "probability": 0.9024135044642857}, {"start": 2990.6, "end": 2990.72, "word": " اللي", "probability": 0.886962890625}, {"start": 2990.72, "end": 2990.88, "word": " بدنا", "probability": 0.910888671875}, {"start": 2990.88, "end": 2991.14, "word": " نحكي", "probability": 0.9898681640625}, {"start": 2991.14, "end": 2991.44, "word": " عنها", "probability": 0.991455078125}, {"start": 2991.44, "end": 2991.64, "word": " أو", "probability": 0.56884765625}, {"start": 2991.64, "end": 2992.14, "word": " التغير", "probability": 0.9274088541666666}, {"start": 2992.14, "end": 2992.32, "word": " اللي", "probability": 0.989013671875}, {"start": 2992.32, "end": 2992.66, "word": " بيصير", "probability": 0.8927001953125}, {"start": 2992.66, "end": 2992.84, "word": " أو", "probability": 0.5556640625}, {"start": 2992.84, "end": 2992.94, "word": " ال", "probability": 0.8876953125}, {"start": 2992.94, "end": 2993.2, "word": " class", "probability": 0.97607421875}, {"start": 2993.2, "end": 2993.56, "word": " switching", "probability": 0.9560546875}, {"start": 2993.56, "end": 2994.04, "word": " بيصير", "probability": 0.9111328125}, {"start": 2994.04, "end": 2994.66, "word": " في", "probability": 0.57568359375}, {"start": 2994.66, "end": 2994.76, "word": " ال", "probability": 0.79833984375}, {"start": 2994.76, "end": 2994.92, "word": " heavy", "probability": 0.94580078125}, {"start": 2994.92, "end": 2995.26, "word": " chain", "probability": 0.931640625}, {"start": 2995.26, "end": 2996.1, "word": " ماشي", "probability": 0.90087890625}], "temperature": 1.0}, {"id": 117, "seek": 302225, "start": 2997.69, "end": 3022.25, "text": "طيب ايش اللي شايفينه قدامكوا شايفينه ان في دي جي ايه مصفطة مرتبطة ب two single اللي هو constant gene و اول constant gene هم عبارة عن ايه؟ الميو و الدلتا ماشي و هم اول اتنين بتصنعوا", "tokens": [9566, 1829, 3555, 1975, 1829, 8592, 13672, 1829, 13412, 995, 33911, 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constant gene في repeated sequence", "tokens": [1211, 19452, 8978, 2423, 8272, 16712, 9381, 5172, 36081, 3660, 20666, 39237, 9122, 6027, 9307, 1829, 4724, 1829, 9381, 13546, 8978, 18871, 16254, 6055, 9381, 5172, 36081, 3660, 24976, 24723, 1696, 4032, 24976, 20588, 4032, 24976, 462, 16592, 4724, 995, 7435, 1829, 16712, 9381, 5172, 36081, 9307, 20449, 8315, 3224, 12174, 12610, 8315, 2423, 691, 48383, 4724, 43500, 49401, 16712, 3794, 27884, 5754, 12186, 5296, 15042, 23032, 1211, 3615, 14407, 15844, 16712, 3794, 27884, 5754, 12186, 5296, 7435, 14407, 16472, 3224, 19446, 49374, 28242, 12186, 16070, 2655, 7649, 1829, 8978, 2423, 5754, 12186, 8978, 10477, 8310], "avg_logprob": -0.29655284488324035, "compression_ratio": 1.8009259259259258, "no_speech_prob": 0.0, "words": [{"start": 3023.76, "end": 3024.26, "word": "لكن", "probability": 0.69873046875}, {"start": 3024.26, "end": 3024.84, "word": " في", "probability": 0.82080078125}, {"start": 3024.84, "end": 3024.92, "word": " ال", 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مع ده الجينين الأولين اللي هو الـ mu و الـ delta يبقى في عندي S region ما بين كل constant gene و التاني هذا هو ماشي يعني في عندي جامعة تلاتة جامعة واحد جامعة اتنين جامعة ايه و بي طبعا هي ال S epsilon S alpha و هكذا", "tokens": [38251, 2407, 11296, 3679, 4458, 318, 4458, 20449, 11778, 3224, 25724, 9957, 9957, 16247, 12610, 9957, 13672, 1829, 31439, 2423, 39184, 2992, 4032, 2423, 39184, 8289, 7251, 3555, 4587, 7578, 8978, 18871, 16254, 318, 4458, 19446, 49374, 28242, 5754, 12186, 4032, 16712, 7649, 1829, 23758, 31439, 3714, 33599, 1829, 37495, 22653, 8978, 18871, 16254, 10874, 10943, 27884, 6055, 1211, 9307, 3660, 10874, 10943, 27884, 36764, 24401, 10874, 10943, 27884, 1975, 2655, 1863, 9957, 10874, 10943, 27884, 1975, 1829, 3224, 4032, 4724, 1829, 23032, 3555, 3615, 995, 39896, 2423, 318, 17889, 318, 8961, 4032, 8032, 4117, 15730], "avg_logprob": -0.280444577797172, "compression_ratio": 1.7605633802816902, "no_speech_prob": 1.7881393432617188e-07, "words": [{"start": 3050.58, "end": 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جامعة", "probability": 0.8942057291666666}, {"start": 3071.64, "end": 3072.08, "word": " واحد", "probability": 0.95703125}, {"start": 3072.08, "end": 3072.44, "word": " جامعة", "probability": 0.9366861979166666}, {"start": 3072.44, "end": 3072.94, "word": " اتنين", "probability": 0.9539794921875}, {"start": 3072.94, "end": 3074.36, "word": " جامعة", "probability": 0.9187825520833334}, {"start": 3074.36, "end": 3074.94, "word": " ايه", "probability": 0.6971028645833334}, {"start": 3074.94, "end": 3075.06, "word": " و", "probability": 0.87646484375}, {"start": 3075.06, "end": 3075.3, "word": " بي", "probability": 0.869873046875}, {"start": 3075.3, "end": 3075.84, "word": " طبعا", "probability": 0.968994140625}, {"start": 3075.84, "end": 3076.66, "word": " هي", "probability": 0.529296875}, {"start": 3076.66, "end": 3076.92, "word": " ال", "probability": 0.822265625}, {"start": 3076.92, "end": 3077.28, "word": " S", "probability": 0.463623046875}, {"start": 3077.28, "end": 3078.02, "word": " epsilon", "probability": 0.342529296875}, {"start": 3078.02, "end": 3078.5, "word": " S", "probability": 0.67724609375}, {"start": 3078.5, "end": 3079.04, "word": " alpha", "probability": 0.611328125}, {"start": 3079.04, "end": 3079.3, "word": " و", "probability": 0.77001953125}, {"start": 3079.3, "end": 3079.66, "word": " هكذا", "probability": 0.8736979166666666}], "temperature": 1.0}, {"id": 120, "seek": 311066, "start": 3081.64, "end": 3110.66, "text": "ماشي يبقى مرة تانية في S region او switch region ما بين كل constant gene و التاني ماعدا اول two genes اللي هم مين اللي هم ال mu و ال delta عشان هي اول ما بتتصنع القضية بتصنع ال mu و ال delta IgM و IgD لكن لما يصلها class switching شو بيصير؟ بتصنع على سبيل المثال gamma يعني IgG شو اللي بيصير؟", "tokens": [2304, 33599, 1829, 7251, 3555, 4587, 7578, 3714, 25720, 6055, 7649, 10632, 8978, 318, 4458, 1975, 2407, 3679, 4458, 19446, 49374, 28242, 5754, 12186, 4032, 16712, 7649, 1829, 19446, 3615, 28259, 1975, 12610, 732, 14424, 13672, 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VTG بتروحوا يشابكة في الجامعون في ال constant gene تبع الجامعون طب و ليه بينهم قالوا هذا بيسموه ايش turning ماشي بالتفة ده و اللفة و طبعا بيصير عملية قطع و recombination", "tokens": [4587, 6027, 14407, 28242, 19446, 34105, 4117, 16472, 2423, 691, 51, 38, 39894, 32887, 5016, 14407, 7251, 8592, 16758, 4117, 3660, 8978, 25724, 10943, 3615, 11536, 8978, 2423, 5754, 12186, 6055, 3555, 3615, 25724, 10943, 3615, 11536, 23032, 3555, 4032, 32239, 3224, 49374, 16095, 50239, 14407, 23758, 4724, 1829, 38251, 2407, 3224, 1975, 1829, 8592, 6246, 3714, 33599, 1829, 20666, 2655, 5172, 3660, 11778, 3224, 4032, 13672, 5172, 3660, 4032, 23032, 3555, 3615, 995, 4724, 1829, 9381, 13546, 6225, 42213, 10632, 12174, 9566, 3615, 4032, 850, 3548, 2486], "avg_logprob": -0.2593047618865967, "compression_ratio": 1.5522388059701493, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 3111.09, "end": 3111.47, "word": "قالوا", "probability": 0.492431640625}, {"start": 3111.47, "end": 3111.69, "word": " كل", 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+ +5 +00:00:33,490 --> 00:00:40,690 +ناجة بالحكة ف دعونا نتتبع بداية ال B cell + +6 +00:00:40,690 --> 00:00:44,870 +development وزي ما انتوا شايفين في ال B cell + +7 +00:00:44,870 --> 00:00:49,730 +development في عندنا ال B lymphocyte develop into + +8 +00:00:49,730 --> 00:00:57,810 +area الأولانيبسموها Generative Lymphoid Organs وهي + +9 +00:00:57,810 --> 00:01:02,610 +عبارة عن الـ Primary Lymphoid Organs وزي ما انتوا + +10 +00:01:02,610 --> 00:01:07,350 +شايفين فيه صورة عضمة يعني الـ B-lymphocyte تنشأ في + +11 +00:01:07,350 --> 00:01:12,510 +الـ bone marrow و تتطور هناك ماشي هي B cell + +12 +00:01:12,510 --> 00:01:17,250 +developed from pluripotent lymphoid pluripotent + +13 +00:01:17,250 --> 00:01:21,170 +stem cell فبقى الـ pluripotent بعد هي كمثلها + +14 +00:01:21,170 --> 00:01:27,020 +differentiation للميرويدلكن كلامها دوام بسير في + +15 +00:01:27,020 --> 00:01:33,300 +البون مارو وفي هذه الحالة بتدل تنتقل من مرحلة إلى + +16 +00:01:33,300 --> 00:01:37,760 +أخرى إلى أن تصل إلى ال mature B lymphocyte اللي هي + +17 +00:01:37,760 --> 00:01:43,140 +عبارة عن IGM positive B cell على سطحها يعني ايش + +18 +00:01:43,140 --> 00:01:53,500 +IGM و IGD طبعا بعد هي كخلية تنتقل الى ايشبتطلع من + +19 +00:01:53,500 --> 00:01:56,260 +البولمار وبتروح ال peripheral blood او peripheral + +20 +00:01:56,260 --> 00:01:59,320 +lymphoid organs والان هنشوف بس خلنا نشوف ايش هي + +21 +00:01:59,320 --> 00:02:03,860 +خصائص ال immature B lymphocytes بيعرف ان خصائصها + +22 +00:02:03,860 --> 00:02:07,760 +انه وجودها بكميات كبيرة في ال peripheral blood + +23 +00:02:07,760 --> 00:02:14,740 +بيصل عددها الى 1 في 10 قواط 11 وكل B lymphocyte + +24 +00:02:14,740 --> 00:02:18,660 +has a distinct antigen receptor بمعنى has + +25 +00:02:18,660 --> 00:02:22,870 +different specificity for different antigenلكن زي + +26 +00:02:22,870 --> 00:02:28,090 +ما اتفقنا ان الـ human genome هو أكبر عن 35 ألف + +27 +00:02:28,090 --> 00:02:31,750 +وطبعا في بعض الحصريات بتقول انه أقل من هيك + +28 +00:02:31,750 --> 00:02:36,450 +فبالتالي كيف هالعدد المحدود من الجينات بيصنع لنا + +29 +00:02:36,450 --> 00:02:42,110 +هالعدد الرهيب الواحد في عشر رقوة أحداشر من ال IGM + +30 +00:02:42,110 --> 00:02:48,250 +او من ال protein طبعا قلنا في محاضرة سابقة انه due + +31 +00:02:48,250 --> 00:02:52,750 +to generation of diversityبصير فيها somatic + +32 +00:02:52,750 --> 00:03:00,290 +recombination لـ gene segments و طبعا هذه it codes + +33 +00:03:00,290 --> 00:03:04,830 +for variable region of the receptor وبالتالي بصير + +34 +00:03:04,830 --> 00:03:08,770 +فينا عدد مهول في كل مرة بتصفط و تصفيتها مختلفة + +35 +00:03:08,770 --> 00:03:16,610 +فبصير فينا عدد مهول من ايش من ال specific PCR على + +36 +00:03:16,610 --> 00:03:22,800 +السطح الخبير اللي كنا بنعرف انهالعملية بتتم كالاتي + +37 +00:03:22,800 --> 00:03:27,460 +لما انه بنحكي على protein و ال protein بتصنع بوسطة + +38 +00:03:27,460 --> 00:03:32,620 +اللي هو gene it's coded by gene فبالتالي ال DNA + +39 +00:03:32,620 --> 00:03:38,440 +هذا هو بدو يتصفط و يدينا في النهاية protein و + +40 +00:03:38,440 --> 00:03:44,800 +الحكاية بتتم كالاتي انه فينا genomic DNA زي ما هو + +41 +00:03:44,800 --> 00:03:47,800 +هذه الترتيبات او الخطوات اللي بيبقوا فيها بيصلوا + +42 +00:03:47,800 --> 00:03:51,550 +transcriptionو بيكون الـ Primary Transcript اللي + +43 +00:03:51,550 --> 00:03:55,550 +بيصيرله Splicing و بيكون Match و Messenger RNA + +44 +00:03:55,550 --> 00:03:58,550 +اللي بعد ذلك بيصيرله Translation و بدينا البروتين + +45 +00:03:58,550 --> 00:04:04,730 +هذا هو التسلسل الطبيعي لتصنيع البروتين في حالة ال + +46 +00:04:04,730 --> 00:04:08,850 +Immunoglobulin اللي بيصير انه بيصير في تصفيت + +47 +00:04:08,850 --> 00:04:13,160 +للجيناتللـ habit chain أول ثم ال lighted chain أخر + +48 +00:04:13,160 --> 00:04:17,840 +ثم الاتنين بعد ذلك بيرتبطوا مع بعض بكونهم ال whole + +49 +00:04:17,840 --> 00:04:21,840 +immunoglobulin بالنسبالي ال habit chain قلنا فيه + +50 +00:04:21,840 --> 00:04:25,200 +three gene segment مسئولة عن variable ترتبط بال + +51 +00:04:25,200 --> 00:04:28,580 +constant gene كلها كل هدول عبارة عن constant gene + +52 +00:04:28,580 --> 00:04:33,100 +تسعة constant gene بترتبط فيهم ال variable region + +53 +00:04:33,100 --> 00:04:40,890 +قلنا three gene segment هي ال B والD والGو V وD وG + +54 +00:04:40,890 --> 00:04:46,570 +بيرتبطوا بكل التسعة constant gene اللي موجودة و + +55 +00:04:46,570 --> 00:04:51,270 +العملية بتتم في بالنسبة لل variable طبعا بيصير فيه + +56 +00:04:51,270 --> 00:04:56,010 +تصفيت للجينات و انا هنشوف كيف تتم التصفيت ال + +57 +00:04:56,010 --> 00:05:00,450 +lighted chain يقولنا اما كابا او اما لامبا و برضه + +58 +00:05:00,450 --> 00:05:05,800 +بيصير فيها تصفيت للجيناتوفيها variable و constant + +59 +00:05:05,800 --> 00:05:09,420 +region ال variable اللى مسؤول عنها two constant + +60 +00:05:09,420 --> 00:05:14,960 +gene segment مرتبطه بال constant gene اللى مسؤول + +61 +00:05:14,960 --> 00:05:21,740 +عن constant variable constant gene كيف يتم عملية + +62 +00:05:21,740 --> 00:05:28,840 +التصفيت بتبدأ ال VDJ في التكون وطبعا ال VDJ بتصير + +63 +00:05:28,840 --> 00:05:35,290 +فيها او بترتبط او بتتكونعلى مرحلتين، المرحلة + +64 +00:05:35,290 --> 00:05:41,510 +الأولى بيصير في ارتباط للـD مع الـJ ثم بعد ذلك + +65 +00:05:41,510 --> 00:05:46,650 +بترتبط الـV معاهم فبالتالي في مرحلتين، يعني في + +66 +00:05:46,650 --> 00:05:48,490 +المرحلة الأولى ان هي بيصير في Somatic + +67 +00:05:48,490 --> 00:05:53,510 +Recombination للـD مع الـJ اللي هي Joining وهذه + +68 +00:05:53,510 --> 00:05:56,390 +الرسمة mainly two clones of cell، two clones of B + +69 +00:05:56,390 --> 00:06:01,570 +lymphocyte فكل واحد بتصفط بتصفط بطريقة مختلفة عن + +70 +00:06:01,570 --> 00:06:06,810 +التانيوهذا هو بعد ذلك ال V بتيجي تشبك معاهم وهي ال + +71 +00:06:06,810 --> 00:06:13,650 +V شبكة 10 فبتكون ال VDJ طبعا ال VDJ بعد ذلك بيصير + +72 +00:06:13,650 --> 00:06:19,750 +له Transcription وهو RNA Processing او Splicing ثم + +73 +00:06:19,750 --> 00:06:23,770 +Translation هو بيكون ليه ال protein اللي احنا + +74 +00:06:23,770 --> 00:06:30,130 +عهدنا حاليا بيصير له ال H بيكون ليه ال proteinاللي + +75 +00:06:30,130 --> 00:06:33,510 +هو الـ habit chain أيضًا ينطبق على ال lights زي ما + +76 +00:06:33,510 --> 00:06:38,430 +قلنا وفي النهاية بيكونونها ال IGF هي زي ما تشوفين + +77 +00:06:38,430 --> 00:06:45,290 +ال VDG هذه برضه two clones of cell ماشي VDG تكون + +78 +00:06:45,290 --> 00:06:49,570 +مرتبط مع ال constant VDG مع ال constant هي ال VDG + +79 +00:06:49,570 --> 00:06:54,330 +recombination رقم واحد ارتبط مع ال constant وهذا + +80 +00:06:54,330 --> 00:06:58,210 +رقم اتنين ارتبط مع ال constant هذا بيستكون ليه + +81 +00:06:58,210 --> 00:07:05,610 +antibodyمختلف في ال specificity عن هذا ال antibody + +82 +00:07:05,610 --> 00:07:08,590 +لكن يجب أن تلاحظ ان ال constant region لم تتأثر + +83 +00:07:08,590 --> 00:07:13,430 +هنا وبالتالي ال two antibodies are the same + +84 +00:07:13,430 --> 00:07:21,230 +classes لكن ال specificity بتختلف هنا هذه واحدة + +85 +00:07:21,230 --> 00:07:27,410 +حمرة وهذه واحدة خارقة يعني النواتج هذه العملية انه + +86 +00:07:27,410 --> 00:07:32,210 +ممكن يكون oneone antibody with different + +87 +00:07:32,210 --> 00:07:37,850 +specificity with ايش؟ ممكن تولدلي one antibody زي + +88 +00:07:37,850 --> 00:07:41,850 +ال IGM مابتطلع على سطح البيلينفسان لكن with + +89 +00:07:41,850 --> 00:07:44,790 +different specificity في كل مرة بتصفر تصفيتها + +90 +00:07:44,790 --> 00:07:50,210 +مختلفة فبديني antibody مختلف على سطح الخلية يعني + +91 +00:07:50,210 --> 00:07:51,530 +ال PCR بيختلف + +92 +00:07:54,530 --> 00:07:57,690 +كل واحد منهم يتجار بشكل مختلف عن الـ Antigen + +93 +00:07:57,690 --> 00:08:08,670 +Specificity الوظائف + +94 +00:08:08,670 --> 00:08:12,090 +البيولوجية + +95 +00:08:12,090 --> 00:08:14,910 +و الفيزيائية هي نفس الشيء + +96 +00:08:20,730 --> 00:08:24,450 +Source of diversity اتفقنا على انه ما ده هي فى عدد + +97 +00:08:24,450 --> 00:08:30,010 +جينات فى كل segment مسئولة عن الهيبوتشين وعن + +98 +00:08:30,010 --> 00:08:36,790 +الكابا وطبعا نفس الحكاية بالنسبة لل TCR Alpha و + +99 +00:08:36,790 --> 00:08:41,510 +Beta طبعا حاصل ضربهم هذا بيقدى ال generation of + +100 +00:08:41,510 --> 00:08:46,750 +diversityأيه بيصير الميكانيزم كcombinatorial + +101 +00:08:46,750 --> 00:08:50,990 +diversity ترتبط ال VD مع J في ال amino global + +102 +00:08:50,990 --> 00:08:54,430 +بيوصل لعدد ل تقريبا مليون تقريبا مليون تقريبا + +103 +00:08:54,430 --> 00:08:57,890 +مليون تقريبا مليون تقريبا مليون تقريبا مليون + +104 +00:08:57,890 --> 00:08:58,230 +مليون تقريبا مليون تقريبا مليون تقريبا مليون + +105 +00:08:58,230 --> 00:08:58,430 +تقريبا مليون تقريبا مليون تقريبا مليون تقريبا + +106 +00:08:58,430 --> 00:09:01,010 +مليون تقريبا مليون تقريبا مليون تقريبا مليون + +107 +00:09:01,010 --> 00:09:08,730 +تقريبا مليون تقريبا مليون تقريبا + +108 +00:09:08,730 --> 00:09:12,510 +مليون + +109 +00:09:12,510 --> 00:09:20,020 +تبنما بالمجمل عددها مهول في الجسم طيب عرفنا خصائص + +110 +00:09:20,020 --> 00:09:22,600 +الـ B lymphocytes الخطوة اللي بعدها زي ما قلنا + +111 +00:09:22,600 --> 00:09:25,600 +بتطلع من الـ bone marrow بتروح عليش ال peripheral + +112 +00:09:25,600 --> 00:09:30,440 +lymphoid organs يعني بتسير ماتشور خلصت من ال bone + +113 +00:09:30,440 --> 00:09:37,820 +marrow و يوم ما تسير ماتشور بتلف + +114 +00:09:37,820 --> 00:09:43,900 +homing phenomena بتظل تلف ما بينما بين ال blood و + +115 +00:09:43,900 --> 00:09:47,660 +ال secondary lymphoid organs looking for antigen + +116 +00:09:47,660 --> 00:09:50,640 +إذا لم تصادف ال antigen it will die through + +117 +00:09:50,640 --> 00:09:56,080 +apoptosis طيب stages of B cell development اتفقنا + +118 +00:09:56,080 --> 00:10:00,200 +انه الخلية لازم ياشت صادف antigen فهي هيوم تصادف + +119 +00:10:00,200 --> 00:10:04,600 +antigen بيصير ال heclonal expansion طبعا بيصير + +120 +00:10:04,600 --> 00:10:08,300 +activation differentiation و proliferationوبالتالي + +121 +00:10:08,300 --> 00:10:16,160 +بيحصل فيه Clonal Expansion طيب، شو اللي بيحصل عشان + +122 +00:10:16,160 --> 00:10:20,080 +تتنشط وتعملنا لـ Clonal Expansion هذا؟ يعني الـ + +123 +00:10:20,080 --> 00:10:23,440 +Naive B cell encounter أنتجن، على فكرة يوم ما تمسك + +124 +00:10:23,440 --> 00:10:27,220 +في الانتجن، بيعتبروها survival signal يعني هي + +125 +00:10:27,220 --> 00:10:33,130 +إشارة النجاة بالنسبة للخليةلأن جماعة صادفة antigen + +126 +00:10:33,130 --> 00:10:38,250 +to die فيوم ما تصادف ال antigen بتتنشط و بتعمر في + +127 +00:10:38,250 --> 00:10:45,530 +الجسم فهي ال IP lymphocytes على سطح IGM و IGD مسكت + +128 +00:10:45,530 --> 00:10:49,210 +في مين؟ مسكت في antigen طبعا يوم ما تمسك في ال + +129 +00:10:49,210 --> 00:10:54,230 +antigen بتقدمه طبعا تاخده تعمله processing ثم بيع + +130 +00:10:55,040 --> 00:10:59,080 +بتطلع مرتبط بالـ MSC موليكيول على سطحها وبتقدم + +131 +00:10:59,080 --> 00:11:05,240 +لمين لـ T-Helper Cell بتقدم لمين لـ T-Helper Cell + +132 +00:11:05,240 --> 00:11:09,140 +وليش T-Helper Cell اللي هي CD4 لإنه الـ B + +133 +00:11:09,140 --> 00:11:13,940 +-Lymphocyte على سطحها MSC Class II موليكيول كي + +134 +00:11:13,940 --> 00:11:18,580 +بتهم العملية يعني هي الـ B-Lymphocyte مسكت في + +135 +00:11:18,580 --> 00:11:25,580 +أنتجن B Cell Recognition of Native Proteinمشي + +136 +00:11:25,580 --> 00:11:31,260 +برتبط بالـ Cognitive Antigen الـ ABCR برتبط بإيش؟ + +137 +00:11:31,260 --> 00:11:38,740 +بأقرب اللي هو الـ Antigen القريب منه شو بيصير في + +138 +00:11:38,740 --> 00:11:42,360 +هذه الحالة؟ قالوا بقت ما نمسك في الـ Receptor + +139 +00:11:42,360 --> 00:11:48,020 +بيصير فيه Endocytosis يعني بدخل في داخل الخلية و + +140 +00:11:48,020 --> 00:11:52,490 +في داخل الخلية الـ Antigen is processedوزي ما قلنا + +141 +00:11:52,490 --> 00:11:55,710 +لكوا بيطلع مرتبط بلامة C class 2 موليكيول على سطح + +142 +00:11:55,710 --> 00:12:00,110 +الخلية وبالتالي ببساطة ال mesel act as a classical + +143 +00:12:00,110 --> 00:12:04,670 +antigen presenting cell بتقدمه لمين ل T helper + +144 +00:12:04,670 --> 00:12:11,050 +cell once طبعا العملية هذه صارت بيصير في + +145 +00:12:11,050 --> 00:12:14,610 +activation طبعا stimulation ل T cell activation + +146 +00:12:14,610 --> 00:12:19,170 +تبدأ عملية تنشيط T lymphocyte لكن عملية التنشيط + +147 +00:12:19,170 --> 00:12:27,820 +تحتاج إلى أيش؟إلى مراحل هى ارتباط ما بين بيسل وما + +148 +00:12:27,820 --> 00:12:32,840 +بين تيسل وشايفين السهمين هدول؟ شو بيعني و المربع + +149 +00:12:32,840 --> 00:12:38,920 +هذا؟ يعني ان الخليتين عشان يتنشطوا بحتاجوا الى two + +150 +00:12:38,920 --> 00:12:44,920 +signal الأولانى ارتباط ال TCR بالانتجن اللى ماسك + +151 +00:12:44,920 --> 00:12:53,270 +فى مين؟ بال MHC moleculeو بيسموها ايش ال first + +152 +00:12:53,270 --> 00:12:57,510 +signal طبعا في هذه ال first signal بيكون ال CD4 + +153 +00:12:57,510 --> 00:13:01,190 +مسك في ال MSC موليكيول ال CD4 اللي جاعد على مين؟ + +154 +00:13:01,190 --> 00:13:04,290 +على سطح ال D-Lymphocyte ومسك في مين؟ في ال MSC + +155 +00:13:04,290 --> 00:13:07,270 +Class II موليكيول اللي جاعد على سطح ال D + +156 +00:13:07,270 --> 00:13:11,510 +-Lymphocyte هذه بيعتبروها first signal هذا هيلكنها + +157 +00:13:11,510 --> 00:13:15,610 +غير كافية لتمشيط الـ T-Lymphocyte فبتروحوا الـ T + +158 +00:13:15,610 --> 00:13:20,530 +-Lymphocyte عاملة أو مرتبطة من خلال Co-Stimulatory + +159 +00:13:20,530 --> 00:13:25,070 +Reaction وإحنا سابقا قلنا إنه يوم الخلية تمسك + +160 +00:13:25,070 --> 00:13:30,270 +Foreign Antigen بصير فيه Co-Stimulation لكن لو الـ + +161 +00:13:30,270 --> 00:13:34,930 +B-Lymphocyte ماسكة على سطح الأمعد C-molecule الـ + +162 +00:13:34,930 --> 00:13:38,810 +Self-antigen لا تتولد الـ Co-Stimulation بسبب الـ + +163 +00:13:38,810 --> 00:13:43,220 +Hash بس لها Down Regulation على طولفهنا صار في up + +164 +00:13:43,220 --> 00:13:45,800 +-regulation للـ co-stimulator من الكليون اللي هي + +165 +00:13:45,800 --> 00:13:55,360 +CD28 بترتبط ب B7 ماشي بعد هيك تينفوسايت بتتنشط + +166 +00:13:55,360 --> 00:14:01,870 +فبتكون و هي عاملة حاجتين ام طلع CD40 لجدعشان يرتبط + +167 +00:14:01,870 --> 00:14:06,510 +في مين هذا هو الـ CD40 اللي موجود على سطح مين الـ + +168 +00:14:06,510 --> 00:14:12,750 +B lymphocyte و بتطلع cytokine بتفرز + +169 +00:14:12,750 --> 00:14:20,910 +حاجتين CD40 لجند و cytokine شو بيصير بعد هيك رقم + +170 +00:14:20,910 --> 00:14:25,810 +تلاتة جاله CD40 بيمسك في CD40 لجند تقوى الرابطة + +171 +00:14:25,810 --> 00:14:30,150 +تقوى الرابطة ضروري ليه تنشيط الـ B lymphocyte نعم + +172 +00:14:30,920 --> 00:14:36,120 +بس في وجود الـ cytokine الـ EH اللي أفرزتها الـ T + +173 +00:14:36,120 --> 00:14:39,280 +-Helper Cell طبعا في هذه الحالة بيصير فيه EH + +174 +00:14:39,280 --> 00:14:42,540 +activation بمعنى انه بيصير فيه proliferation و + +175 +00:14:42,540 --> 00:14:47,120 +differentiation و بيصير فيه clonal expansion لهذه + +176 +00:14:47,120 --> 00:14:51,120 +الخلية اللي بتتنشط و بتتحول ل B cell و ده يصار + +177 +00:14:51,120 --> 00:14:56,520 +تتطلع انها EH antibody هي antibody-secreting cell + +178 +00:14:56,520 --> 00:15:01,860 +سموها antibody-secreting cellبنشوف ايش اللي بيصير + +179 +00:15:01,860 --> 00:15:05,500 +يبقى صار فيه عملية activation هي activated للبيه + +180 +00:15:05,500 --> 00:15:11,120 +الانفسايد نشطة عملية Clonal Expansion وكان عملية + +181 +00:15:11,120 --> 00:15:15,900 +ال Clonal Expansion هم متفاقينإن كل خلية عبارة عن + +182 +00:15:15,900 --> 00:15:18,520 +عدد من خلايا الـ B lymphocyte اللي موجودة في الجسم + +183 +00:15:18,520 --> 00:15:23,300 +وزي ما تشايفين هم ألوان مختلفة لأنه على سطح لأن ال + +184 +00:15:23,300 --> 00:15:27,800 +specificity تبعتهم مختلفة specificity تبعت مين كل + +185 +00:15:27,800 --> 00:15:32,120 +ال PCR على سطحها بيرتبط و ده different antigen it + +186 +00:15:32,120 --> 00:15:36,960 +has unique specificity فلو شفنا مثلا على سبيل + +187 +00:15:36,960 --> 00:15:44,590 +المثال خلية صادفت تمسك في antigenالتي ليست محددة + +188 +00:15:44,590 --> 00:15:50,870 +لها وليس هناك ارتباط لكن يوم يطلع الانتجن محدد لـ + +189 +00:15:50,870 --> 00:15:57,870 +PCR اللي موجودة هتمسك فيه طبعا في نظريتين بتقولوا + +190 +00:15:57,870 --> 00:16:00,590 +نظرية الأولى بتقول ان ال white BCG اللي بتدور على + +191 +00:16:00,590 --> 00:16:03,840 +الانتجن وفي بعض مراتبعض المراجعين يقولون ان + +192 +00:16:03,840 --> 00:16:28,760 +الانتيجين يبحث عن خلق + +193 +00:16:28,760 --> 00:16:30,320 +خلق محدد لعينه لعينه لعينه لعينه لعينه لعينه لعينه + +194 +00:16:30,320 --> 00:16:30,580 +لعينه لعينه لعينه لعينه لعينه لعينه لعينه لعينه + +195 +00:16:30,580 --> 00:16:33,530 +لعينه لعفبصير فيه Clonal Expansion طب بعدها شو + +196 +00:16:33,530 --> 00:16:37,110 +بيصير؟ قالوا هذه الخلية بتطبس لها differentiation + +197 +00:16:37,110 --> 00:16:43,510 +و بتكون لنا antibody secreting cell ده هي عبارة عن + +198 +00:16:43,510 --> 00:16:47,370 +plasma cell اللي بتفرز لنا antibody و في ال acute + +199 +00:16:47,370 --> 00:16:52,770 +infection ال primary بتطلع لنا IgM IgM إيه؟ + +200 +00:16:52,770 --> 00:16:58,470 +antibody secreted antibody secreted cell و في نفس + +201 +00:16:58,470 --> 00:17:04,070 +الوقت تنقسم و بتديني كماناللي هو Memory Cell دتني + +202 +00:17:04,070 --> 00:17:07,510 +ايه؟ Factor Cell ودتنا ايه؟ Memory Cell و ال + +203 +00:17:07,510 --> 00:17:10,690 +Memory Cell اللي ابنى هنعرفها هي عبارة عن + +204 +00:17:10,690 --> 00:17:16,130 +Quiescent Form of B of Plasma Cell Of إيش؟ Of + +205 +00:17:16,130 --> 00:17:21,230 +Plasma Cell اللي دوري ممكن تتنشط وب high affinity + +206 +00:17:21,230 --> 00:17:28,950 +لإيش؟ ل ال antigen انو antigen اللي أصلا مسكت فيه + +207 +00:17:28,950 --> 00:17:34,500 +ال B lymphocyte من الأولتا هي ال memory cell + +208 +00:17:34,500 --> 00:17:39,260 +يتكوّن من أكتف سل لينفوسايت تختار من memory cell + +209 +00:17:39,260 --> 00:17:44,720 +لفكتور سل ال memory cell هي برعنة من نييف + +210 +00:17:44,720 --> 00:17:48,700 +لينفوسايت خلية أول مرة بتشوف الانتجن as a result + +211 +00:17:48,700 --> 00:17:53,040 +of antigen exposure وبتقعد just for years in a + +212 +00:17:53,040 --> 00:17:57,780 +quiescent state في وضع خامل في وضع ساكن سكون + +213 +00:18:00,350 --> 00:18:10,350 +بتنشط بسرعة فظيعة تتنشط بسرعة + +214 +00:18:10,350 --> 00:18:13,310 +فظيعة تتنشط بسرعة فظيعة تتنشط بسرعة فظيعة تتنشط + +215 +00:18:13,310 --> 00:18:13,430 +بسرعة فظيعة تتنشط بسرعة فظيعة تتنشط بسرعة فظيعة + +216 +00:18:13,430 --> 00:18:13,990 +تتنشط بسرعة فظيعة تتنشط بسرعة فظيعة تتنشط بسرعة + +217 +00:18:13,990 --> 00:18:15,990 +فظيعة تتنشط بسرعة فظيعة تتنشط بسرعة فظيعة تتنشط + +218 +00:18:15,990 --> 00:18:19,030 +بسرعة فظيعة تتنشط بسرعة فظيعة تتنشط بسرعة فظيعة + +219 +00:18:19,030 --> 00:18:26,770 +تتنشط بسرعة فظيعة تتنشط بسرعة فظيعة تتنفي الـ + +220 +00:18:26,770 --> 00:18:30,150 +Primary Immune Response كما تشاهدون نحن نعرف في + +221 +00:18:30,150 --> 00:18:33,170 +مرحلة مخادرة السابقة حكينا على ان ال Primary + +222 +00:18:33,170 --> 00:18:37,350 +Immune Response عندما يدخل الانتيجن ال Primary + +223 +00:18:37,350 --> 00:18:40,190 +Immune Response يمر في عدة مراحل أول مرحلة ال lag + +224 +00:18:40,190 --> 00:18:42,970 +phase ثم ال exponential phase اللي بيصير فيه + +225 +00:18:42,970 --> 00:18:45,590 +activation للميليم فسايت و generation و antibody + +226 +00:18:45,590 --> 00:18:50,210 +ثم ال steady أو ال plateau phase وده عبارة عن + +227 +00:18:50,210 --> 00:18:55,730 +phase بتتساوى فيه اللي هو ال generation و antibody + +228 +00:18:56,290 --> 00:19:03,290 +والـ dying of antigen ثم بيصير فيه ال .. ال .. ال + +229 +00:19:03,290 --> 00:19:08,850 +decline لل care لإنه خلاص بتشير الخلايا أو ال + +230 +00:19:08,850 --> 00:19:14,750 +antibody اللي موجودة أكتر بكثير من مين من ال + +231 +00:19:14,750 --> 00:19:19,570 +antigen اللي موجود طبعا تقعد بلازم سيلف البنمرغ و + +232 +00:19:19,570 --> 00:19:22,450 +بتدخل تفرز و بتفرز على طول كمية كبيرة من ال + +233 +00:19:22,450 --> 00:19:26,390 +antibody ليش؟ ليه بشكل المناعة بعد هيك؟في الـ + +234 +00:19:26,390 --> 00:19:30,230 +secondary طبعاً بيكون faster و more potent زي ما + +235 +00:19:30,230 --> 00:19:36,170 +اتفقنا نفسي لحكاية لكن ايش بيكون once the + +236 +00:19:36,170 --> 00:19:39,190 +infection is repeated by the same antigen بيصير + +237 +00:19:39,190 --> 00:19:41,970 +فيه secondary بس زي ما انتوا شايفين في ال + +238 +00:19:41,970 --> 00:19:44,670 +secondary ال antibody اتغير لأنه صار في class + +239 +00:19:44,670 --> 00:19:54,930 +switching وتكون IGG بدل IGA من وصفاتهIt's faster + +240 +00:19:54,930 --> 00:19:59,570 +ال secondary زي ما انتوا شايفين ال face واحد لثلاث + +241 +00:19:59,570 --> 00:20:05,490 +أيام في ال primary من خمسة لعشرة it's stronger ال + +242 +00:20:05,490 --> 00:20:08,910 +peak response في ال primary small لكن في ال ash + +243 +00:20:08,910 --> 00:20:13,950 +secondary it's larger ال antibody is more specific + +244 +00:20:13,950 --> 00:20:17,650 +more ash specific و في نفس الوقت يعني له high + +245 +00:20:17,650 --> 00:20:21,970 +affinity و في نفس الوقت صار فيه ال class watching + +246 +00:20:21,970 --> 00:20:30,260 +phenomenonطيب يبقى هدا هي صار في إيش صار في نوع + +247 +00:20:30,260 --> 00:20:33,540 +تالت من إيش ال activation بالاحتمالات أما antibody + +248 +00:20:33,540 --> 00:20:36,760 +-secreting in a vector cell و أما memory cell و + +249 +00:20:36,760 --> 00:20:41,440 +أما صار في class switching once the infection is + +250 +00:20:41,440 --> 00:20:46,060 +repeated و ال class switching برضه أحنا حكينا فيها + +251 +00:20:46,060 --> 00:20:49,320 +قبل هيك أن ال wheel lymphocyte is not committed to + +252 +00:20:49,320 --> 00:20:54,590 +produce one single immunoglobulin foreverوإنما + +253 +00:20:54,590 --> 00:20:58,590 +ممكن هذا الـ Antibody يتغير بس شوفوا هنا .. كيف ال + +254 +00:20:58,590 --> 00:21:02,190 +team بتتغير؟ طبعا هي في البداية بتطلع IGM لأن أول + +255 +00:21:02,190 --> 00:21:07,370 +constant gene مرتبط فيها هو الـ Mu chain فبتطلع Mu + +256 +00:21:07,370 --> 00:21:11,290 +وDelta ومافيش بينهم repeated sequence وبالتالي + +257 +00:21:11,290 --> 00:21:14,930 +اتنين بيطلعوا مع بعض لكن من الباقى في repeated + +258 +00:21:14,930 --> 00:21:19,790 +sequence ومنها switch region فلو .. لو صارت class + +259 +00:21:19,790 --> 00:21:24,930 +switching شو اللي بيصير؟طبعا في البداية primary + +260 +00:21:24,930 --> 00:21:30,750 +اتمنى انه IGN يوم مايصير فيه class switching شوفوا + +261 +00:21:30,750 --> 00:21:38,750 +ايش اللي بيصير جالو ال DNA بلف لفة أو لفتين طبعا + +262 +00:21:38,750 --> 00:21:46,390 +هنا متى مالف بيصير عملية ايش اللي هو ال delta و ال + +263 +00:21:46,390 --> 00:21:53,040 +ميو بنقطعه by restriction enzymeو ال variable + +264 +00:21:53,040 --> 00:21:56,740 +region بيصير في هذه الحالة شبك مع الجامعة فمين + +265 +00:21:56,740 --> 00:22:03,300 +اللي بيطلع لل antipathy في هذه الحالة IGG بس بدى + +266 +00:22:03,300 --> 00:22:06,180 +تلاحظوا في ال class switching فنومنات ان التغير + +267 +00:22:06,180 --> 00:22:09,520 +اللي هو بيصير التغير بيصير في ال constant region + +268 +00:22:09,520 --> 00:22:13,180 +هي تحولت من ال mu ل جامعة طب و ال variable + +269 +00:22:17,560 --> 00:22:21,640 +الـ Antibody class هو اللي اتغير، الـisotype هو + +270 +00:22:21,640 --> 00:22:25,920 +اللي اتغير، لكن ال specificity دلت مش the same + +271 +00:22:25,920 --> 00:22:31,820 +فأول كان فينا IgM، صار IgG، لكن ال both are + +272 +00:22:31,820 --> 00:22:33,640 +specific for the same antigen + +273 +00:22:37,100 --> 00:22:40,860 +الـ Class-switching Phenomena تشرح لماذا الـ IgM + +274 +00:22:40,860 --> 00:22:44,300 +لا يتم رؤيه عن طريق الـ Re-exposure لـ الانتجين. + +275 +00:22:44,900 --> 00:22:48,740 +هكذا نفسر لماذا لا يتم رؤيه عن طريق الـ IgM مرة + +276 +00:22:48,740 --> 00:22:58,720 +أخرى. طبعا الـ IgM هو عبارة عن PCR على سطح الخلية + +277 +00:22:58,720 --> 00:23:03,600 +يوم ما يرتبط بالانتجين الـ Cognitive Antigen تابعه + +278 +00:23:03,950 --> 00:23:08,410 +طبعاً بيحصل في activation وsecretion لـ IgM لكن + +279 +00:23:08,410 --> 00:23:13,850 +هذا الـ IgM ممكن يتحول إلى IgG يوم ما ينمسك فيه + +280 +00:23:13,850 --> 00:23:18,630 +the same antigen وبالتالي ممكن يدينا IgG، IgA أو + +281 +00:23:18,630 --> 00:23:23,870 +IgE هذه ال class switching فنومنا نرجو أن تكونوا + +282 +00:23:23,870 --> 00:23:28,590 +ممكن استفدتم من هذه المحاضرة و + +283 +00:23:36,450 --> 00:23:37,010 +عشان الله + 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128123, "start": 1254.13, "end": 1281.23, "text": "وإنما ممكن هذا الـ Antibody يتغير بس شوفوا هنا .. كيف ال team بتتغير؟ طبعا هي في البداية بتطلع IGM لأن أول constant gene مرتبط فيها هو الـ Mu chain فبتطلع Mu وDelta ومافيش بينهم repeated sequence وبالتالي اتنين بيطلعوا مع بعض لكن من الباقى في repeated sequence ومنها switch region فلو .. لو صارت class switching شو اللي بيصير؟", "tokens": [2407, 28814, 1863, 15042, 3714, 43020, 23758, 2423, 39184, 5130, 897, 843, 7251, 2655, 17082, 13546, 4724, 3794, 13412, 38688, 14407, 34105, 4386, 9122, 33911, 2423, 1469, 39894, 2655, 17082, 13546, 22807, 23032, 3555, 3615, 995, 39896, 8978, 29739, 28259, 10632, 39894, 9566, 1211, 3615, 26367, 44, 5296, 33456, 5551, 12610, 5754, 12186, 3714, 43500, 3555, 9566, 8978, 11296, 31439, 2423, 39184, 15601, 5021, 6156, 3555, 2655, 9566, 1211, 3615, 15601, 4032, 40848, 1328, 4032, 15042, 41185, 8592, 49374, 16095, 10477, 8310, 46599, 6027, 2655, 6027, 1829, 1975, 2655, 1863, 9957, 4724, 1829, 9566, 1211, 3615, 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شبك مع الجامعة فمين اللي بيطلع لل antipathy في هذه الحالة IGG بس بدى تلاحظوا في ال class switching فنومنات ان التغير اللي هو بيصير التغير بيصير في ال constant region هي تحولت من ال mu ل جامعة طب و ال variable", "tokens": [2407, 2423, 7006, 4458, 4724, 1829, 9381, 13546, 8978, 29538, 21542, 6027, 3660, 13412, 3555, 4117, 20449, 25724, 10943, 27884, 6156, 2304, 9957, 13672, 1829, 4724, 1829, 9566, 1211, 3615, 24976, 2511, 647, 9527, 8978, 29538, 21542, 6027, 3660, 26367, 38, 4724, 3794, 47525, 7578, 6055, 15040, 5016, 19913, 14407, 8978, 2423, 1508, 16493, 6156, 1863, 20498, 8315, 2655, 16472, 16712, 17082, 13546, 13672, 1829, 31439, 4724, 1829, 9381, 13546, 16712, 17082, 13546, 4724, 1829, 9381, 13546, 8978, 2423, 5754, 4458, 39896, 6055, 5016, 12610, 2655, 9154, 2423, 2992, 5296, 10874, 10943, 27884, 23032, 3555, 4032, 2423, 7006], "avg_logprob": -0.3128156475346498, "compression_ratio": 1.807511737089202, "no_speech_prob": 1.0728836059570312e-06, "words": [{"start": 1312.06, "end": 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"word": " ال", "probability": 0.921875}, {"start": 1328.66, "end": 1329.08, "word": " constant", "probability": 0.97119140625}, {"start": 1329.08, "end": 1329.52, "word": " region", "probability": 0.970703125}, {"start": 1329.52, "end": 1329.72, "word": " هي", "probability": 0.8505859375}, {"start": 1329.72, "end": 1330.36, "word": " تحولت", "probability": 0.9052734375}, {"start": 1330.36, "end": 1330.52, "word": " من", "probability": 0.9912109375}, {"start": 1330.52, "end": 1330.62, "word": " ال", "probability": 0.64501953125}, {"start": 1330.62, "end": 1330.94, "word": " mu", "probability": 0.1978759765625}, {"start": 1330.94, "end": 1331.62, "word": " ل", "probability": 0.95068359375}, {"start": 1331.62, "end": 1332.28, "word": " جامعة", "probability": 0.7387288411458334}, {"start": 1332.28, "end": 1332.7, "word": " طب", "probability": 0.918701171875}, {"start": 1332.7, "end": 1332.76, "word": " و", "probability": 0.724609375}, {"start": 1332.76, "end": 1332.84, "word": " ال", "probability": 0.9423828125}, {"start": 1332.84, "end": 1333.18, "word": " variable", "probability": 0.9443359375}], "temperature": 1.0}, {"id": 50, "seek": 135364, "start": 1337.56, "end": 1353.64, "text": "الـ Antibody class هو اللي اتغير، الـisotype هو اللي اتغير، لكن ال specificity دلت مش the same فأول كان فينا IgM، صار IgG، لكن ال both are specific for the same antigen", "tokens": [6027, 39184, 5130, 897, 843, 1508, 31439, 13672, 1829, 1975, 2655, 17082, 13546, 12399, 2423, 39184, 271, 13108, 31439, 13672, 1829, 1975, 2655, 17082, 13546, 12399, 44381, 2423, 2685, 507, 11778, 1211, 2655, 37893, 264, 912, 6156, 10721, 12610, 25961, 8978, 8315, 19271, 44, 12399, 20328, 9640, 19271, 38, 12399, 44381, 2423, 1293, 366, 2685, 337, 264, 912, 2511, 3213], "avg_logprob": -0.4590163953968736, "compression_ratio": 1.4135802469135803, "no_speech_prob": 5.960464477539062e-07, "words": [{"start": 1337.5600000000002, "end": 1338.38, "word": "الـ", "probability": 0.1986083984375}, {"start": 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{"start": 1344.5, "end": 1344.98, "word": " دلت", "probability": 0.71533203125}, {"start": 1344.98, "end": 1345.38, "word": " مش", "probability": 0.07330322265625}, {"start": 1345.38, "end": 1345.54, "word": " the", "probability": 0.302978515625}, {"start": 1345.54, "end": 1345.92, "word": " same", "probability": 0.90234375}, {"start": 1345.92, "end": 1347.0, "word": " فأول", "probability": 0.767578125}, {"start": 1347.0, "end": 1347.2, "word": " كان", "probability": 0.935546875}, {"start": 1347.2, "end": 1347.52, "word": " فينا", "probability": 0.6082763671875}, {"start": 1347.52, "end": 1348.28, "word": " IgM،", "probability": 0.60498046875}, {"start": 1348.28, "end": 1348.42, "word": " صار", "probability": 0.7015380859375}, {"start": 1348.42, "end": 1349.2, "word": " IgG،", "probability": 0.8486328125}, {"start": 1349.2, "end": 1349.54, "word": " لكن", "probability": 0.955078125}, {"start": 1349.54, "end": 1350.74, "word": " ال", "probability": 0.65185546875}, {"start": 1350.74, 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الـ", "probability": 0.866455078125}, {"start": 1367.6, "end": 1368.0, "word": " IgM", "probability": 0.924072265625}, {"start": 1368.0, "end": 1368.74, "word": " مرة", "probability": 0.766845703125}, {"start": 1368.74, "end": 1369.22, "word": " أخرى.", "probability": 0.97900390625}, {"start": 1370.4, "end": 1371.3, "word": " طبعا", "probability": 0.762969970703125}, {"start": 1371.3, "end": 1371.3, "word": " الـ", "probability": 0.54150390625}, {"start": 1371.3, "end": 1374.24, "word": " IgM", "probability": 0.95361328125}, {"start": 1374.24, "end": 1374.42, "word": " هو", "probability": 0.96142578125}, {"start": 1374.42, "end": 1374.68, "word": " عبارة", "probability": 0.9248046875}, {"start": 1374.68, "end": 1375.76, "word": " عن", "probability": 0.9833984375}, {"start": 1375.76, "end": 1377.36, "word": " PCR", "probability": 0.60986328125}, {"start": 1377.36, "end": 1377.84, "word": " على", "probability": 0.89111328125}, {"start": 1377.84, "end": 1378.14, "word": " سطح", "probability": 0.9710286458333334}, {"start": 1378.14, "end": 1378.72, "word": " الخلية", "probability": 0.9513346354166666}, {"start": 1378.72, "end": 1379.74, "word": " يوم", "probability": 0.7237548828125}, {"start": 1379.74, "end": 1379.92, "word": " ما", "probability": 0.78076171875}, {"start": 1379.92, "end": 1380.34, "word": " يرتبط", "probability": 0.9755859375}, {"start": 1380.34, "end": 1381.28, "word": " بالانتجين", "probability": 0.83388671875}, {"start": 1381.28, "end": 1382.1, "word": " الـ", "probability": 0.416259765625}, {"start": 1382.1, "end": 1382.54, "word": " Cognitive", "probability": 0.646728515625}, {"start": 1382.54, "end": 1383.04, "word": " Antigen", "probability": 0.955322265625}, {"start": 1383.04, "end": 1383.6, "word": " تابعه", "probability": 0.731689453125}], "temperature": 1.0}, {"id": 52, "seek": 140859, "start": 1383.95, "end": 1408.59, "text": "طبعاً بيحصل في activation وsecretion لـ IgM لكن هذا الـ IgM ممكن يتحول إلى IgG يوم ما ينمسك فيه the same antigen وبالتالي ممكن يدينا IgG، IgA أو IgE هذه ال class switching فنومنا نرجو أن تكونوا ممكن استفدتم من هذه المحاضرة و", "tokens": [9566, 3555, 3615, 995, 14111, 4724, 1829, 5016, 36520, 8978, 24433, 4032, 8159, 1505, 313, 5296, 39184, 19271, 44, 44381, 23758, 2423, 39184, 19271, 44, 3714, 43020, 7251, 2655, 5016, 12610, 30731, 19271, 38, 7251, 20498, 19446, 7251, 1863, 2304, 3794, 4117, 8978, 3224, 264, 912, 2511, 3213, 46599, 6027, 2655, 6027, 1829, 3714, 43020, 7251, 3215, 9957, 995, 19271, 38, 12399, 19271, 32, 34051, 19271, 36, 29538, 2423, 1508, 16493, 6156, 1863, 20498, 8315, 8717, 47341, 2407, 14739, 6055, 30544, 14407, 3714, 43020, 44713, 5172, 3215, 39237, 9154, 29538, 9673, 5016, 46958, 25720, 4032], "avg_logprob": -0.29443358536809683, "compression_ratio": 1.502202643171806, "no_speech_prob": 1.7881393432617188e-06, "words": [{"start": 1383.95, "end": 1384.39, "word": "طبعاً", "probability": 0.701220703125}, {"start": 1384.39, "end": 1384.75, "word": " بيحصل", 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1404.09, "word": " ممكن", "probability": 0.4898681640625}, {"start": 1404.09, "end": 1404.85, "word": " استفدتم", "probability": 0.833984375}, {"start": 1404.85, "end": 1405.61, "word": " من", "probability": 0.5556640625}, {"start": 1405.61, "end": 1405.97, "word": " هذه", "probability": 0.97021484375}, {"start": 1405.97, "end": 1407.03, "word": " المحاضرة", "probability": 0.9658203125}, {"start": 1407.03, "end": 1408.59, "word": " و", "probability": 0.60400390625}], "temperature": 1.0}, {"id": 53, "seek": 141701, "start": 1416.45, "end": 1417.01, "text": "عشان الله", "tokens": [3615, 8592, 7649, 21984], "avg_logprob": -0.558203125, "compression_ratio": 0.7391304347826086, "no_speech_prob": 0.0, "words": [{"start": 1416.45, "end": 1416.73, "word": "عشان", "probability": 0.5496826171875}, {"start": 1416.73, "end": 1417.01, "word": " الله", "probability": 0.96240234375}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 1424.613875, "duration_after_vad": 1366.3037499999991} \ No newline at end of file diff --git a/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/fdnXqJ800nk_raw.srt b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/fdnXqJ800nk_raw.srt new file mode 100644 index 0000000000000000000000000000000000000000..cf7a9be885fcacc5a530761e39229bf04d309087 --- /dev/null +++ b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/fdnXqJ800nk_raw.srt @@ -0,0 +1,1152 @@ +1 +00:00:03,780 --> 00:00:11,260 +بسم الله الرحمن الرحيم و بيه نستعين و عليه نتوكل و + +2 +00:00:11,260 --> 00:00:20,100 +أجمعين اليوم ان شاء الله هنلتقي في محاضرتين الأولى + +3 +00:00:20,100 --> 00:00:24,980 +هي برعن بي سيل دفلوبمنت والتانية هي برعن تي سيل + +4 +00:00:24,980 --> 00:00:33,490 +دفلوبمنت and bothهو عبارة عن Review لكلام كتير حكي + +5 +00:00:33,490 --> 00:00:40,690 +ناجة بالحكة ف دعونا نتتبع بداية ال B cell + +6 +00:00:40,690 --> 00:00:44,870 +development وزي ما انتوا شايفين في ال B cell + +7 +00:00:44,870 --> 00:00:49,730 +development في عندنا ال B lymphocyte develop into + +8 +00:00:49,730 --> 00:00:57,810 +area الأولانيبسموها Generative Lymphoid Organs وهي + +9 +00:00:57,810 --> 00:01:02,610 +عبارة عن الـ Primary Lymphoid Organs وزي ما انتوا + +10 +00:01:02,610 --> 00:01:07,350 +شايفين فيه صورة عضمة يعني الـ B-lymphocyte تنشأ في + +11 +00:01:07,350 --> 00:01:12,510 +الـ bone marrow و تتطور هناك ماشي هي B cell + +12 +00:01:12,510 --> 00:01:17,250 +developed from pluripotent lymphoid pluripotent + +13 +00:01:17,250 --> 00:01:21,170 +stem cell فبقى الـ pluripotent بعد هي كمثلها + +14 +00:01:21,170 --> 00:01:27,020 +differentiation للميرويدلكن كلامها دوام بسير في + +15 +00:01:27,020 --> 00:01:33,300 +البون مارو وفي هذه الحالة بتدل تنتقل من مرحلة إلى + +16 +00:01:33,300 --> 00:01:37,760 +أخرى إلى أن تصل إلى ال mature B lymphocyte اللي هي + +17 +00:01:37,760 --> 00:01:43,140 +عبارة عن IGM positive B cell على سطحها يعني ايش + +18 +00:01:43,140 --> 00:01:53,500 +IGM و IGD طبعا بعد هي كخلية تنتقل الى ايشبتطلع من + +19 +00:01:53,500 --> 00:01:56,260 +البولمار وبتروح ال peripheral blood او peripheral + +20 +00:01:56,260 --> 00:01:59,320 +lymphoid organs والان هنشوف بس خلنا نشوف ايش هي + +21 +00:01:59,320 --> 00:02:03,860 +خصائص ال immature B lymphocytes بيعرف ان خصائصها + +22 +00:02:03,860 --> 00:02:07,760 +انه وجودها بكميات كبيرة في ال peripheral blood + +23 +00:02:07,760 --> 00:02:14,740 +بيصل عددها الى 1 في 10 قواط 11 وكل B lymphocyte + +24 +00:02:14,740 --> 00:02:18,660 +has a distinct antigen receptor بمعنى has + +25 +00:02:18,660 --> 00:02:22,870 +different specificity for different antigenلكن زي + +26 +00:02:22,870 --> 00:02:28,090 +ما اتفقنا ان الـ human genome هو أكبر عن 35 ألف + +27 +00:02:28,090 --> 00:02:31,750 +وطبعا في بعض الحصريات بتقول انه أقل من هيك + +28 +00:02:31,750 --> 00:02:36,450 +فبالتالي كيف هالعدد المحدود من الجينات بيصنع لنا + +29 +00:02:36,450 --> 00:02:42,110 +هالعدد الرهيب الواحد في عشر رقوة أحداشر من ال IGM + +30 +00:02:42,110 --> 00:02:48,250 +او من ال protein طبعا قلنا في محاضرة سابقة انه due + +31 +00:02:48,250 --> 00:02:52,750 +to generation of diversityبصير فيها somatic + +32 +00:02:52,750 --> 00:03:00,290 +recombination لـ gene segments و طبعا هذه it codes + +33 +00:03:00,290 --> 00:03:04,830 +for variable region of the receptor وبالتالي بصير + +34 +00:03:04,830 --> 00:03:08,770 +فينا عدد مهول في كل مرة بتصفط و تصفيتها مختلفة + +35 +00:03:08,770 --> 00:03:16,610 +فبصير فينا عدد مهول من ايش من ال specific PCR على + +36 +00:03:16,610 --> 00:03:22,800 +السطح الخبير اللي كنا بنعرف انهالعملية بتتم كالاتي + +37 +00:03:22,800 --> 00:03:27,460 +لما انه بنحكي على protein و ال protein بتصنع بوسطة + +38 +00:03:27,460 --> 00:03:32,620 +اللي هو gene it's coded by gene فبالتالي ال DNA + +39 +00:03:32,620 --> 00:03:38,440 +هذا هو بدو يتصفط و يدينا في النهاية protein و + +40 +00:03:38,440 --> 00:03:44,800 +الحكاية بتتم كالاتي انه فينا genomic DNA زي ما هو + +41 +00:03:44,800 --> 00:03:47,800 +هذه الترتيبات او الخطوات اللي بيبقوا فيها بيصلوا + +42 +00:03:47,800 --> 00:03:51,550 +transcriptionو بيكون الـ Primary Transcript اللي + +43 +00:03:51,550 --> 00:03:55,550 +بيصيرله Splicing و بيكون Match و Messenger RNA + +44 +00:03:55,550 --> 00:03:58,550 +اللي بعد ذلك بيصيرله Translation و بدينا البروتين + +45 +00:03:58,550 --> 00:04:04,730 +هذا هو التسلسل الطبيعي لتصنيع البروتين في حالة ال + +46 +00:04:04,730 --> 00:04:08,850 +Immunoglobulin اللي بيصير انه بيصير في تصفيت + +47 +00:04:08,850 --> 00:04:13,160 +للجيناتللـ habit chain أول ثم ال lighted chain أخر + +48 +00:04:13,160 --> 00:04:17,840 +ثم الاتنين بعد ذلك بيرتبطوا مع بعض بكونهم ال whole + +49 +00:04:17,840 --> 00:04:21,840 +immunoglobulin بالنسبالي ال habit chain قلنا فيه + +50 +00:04:21,840 --> 00:04:25,200 +three gene segment مسئولة عن variable ترتبط بال + +51 +00:04:25,200 --> 00:04:28,580 +constant gene كلها كل هدول عبارة عن constant gene + +52 +00:04:28,580 --> 00:04:33,100 +تسعة constant gene بترتبط فيهم ال variable region + +53 +00:04:33,100 --> 00:04:40,890 +قلنا three gene segment هي ال B والD والGو V وD وG + +54 +00:04:40,890 --> 00:04:46,570 +بيرتبطوا بكل التسعة constant gene اللي موجودة و + +55 +00:04:46,570 --> 00:04:51,270 +العملية بتتم في بالنسبة لل variable طبعا بيصير فيه + +56 +00:04:51,270 --> 00:04:56,010 +تصفيت للجينات و انا هنشوف كيف تتم التصفيت ال + +57 +00:04:56,010 --> 00:05:00,450 +lighted chain يقولنا اما كابا او اما لامبا و برضه + +58 +00:05:00,450 --> 00:05:05,800 +بيصير فيها تصفيت للجيناتوفيها variable و constant + +59 +00:05:05,800 --> 00:05:09,420 +region ال variable اللى مسؤول عنها two constant + +60 +00:05:09,420 --> 00:05:14,960 +gene segment مرتبطه بال constant gene اللى مسؤول + +61 +00:05:14,960 --> 00:05:21,740 +عن constant variable constant gene كيف يتم عملية + +62 +00:05:21,740 --> 00:05:28,840 +التصفيت بتبدأ ال VDJ في التكون وطبعا ال VDJ بتصير + +63 +00:05:28,840 --> 00:05:35,290 +فيها او بترتبط او بتتكونعلى مرحلتين، المرحلة + +64 +00:05:35,290 --> 00:05:41,510 +الأولى بيصير في ارتباط للـD مع الـJ ثم بعد ذلك + +65 +00:05:41,510 --> 00:05:46,650 +بترتبط الـV معاهم فبالتالي في مرحلتين، يعني في + +66 +00:05:46,650 --> 00:05:48,490 +المرحلة الأولى ان هي بيصير في Somatic + +67 +00:05:48,490 --> 00:05:53,510 +Recombination للـD مع الـJ اللي هي Joining وهذه + +68 +00:05:53,510 --> 00:05:56,390 +الرسمة mainly two clones of cell، two clones of B + +69 +00:05:56,390 --> 00:06:01,570 +lymphocyte فكل واحد بتصفط بتصفط بطريقة مختلفة عن + +70 +00:06:01,570 --> 00:06:06,810 +التانيوهذا هو بعد ذلك ال V بتيجي تشبك معاهم وهي ال + +71 +00:06:06,810 --> 00:06:13,650 +V شبكة 10 فبتكون ال VDJ طبعا ال VDJ بعد ذلك بيصير + +72 +00:06:13,650 --> 00:06:19,750 +له Transcription وهو RNA Processing او Splicing ثم + +73 +00:06:19,750 --> 00:06:23,770 +Translation هو بيكون ليه ال protein اللي احنا + +74 +00:06:23,770 --> 00:06:30,130 +عهدنا حاليا بيصير له ال H بيكون ليه ال proteinاللي + +75 +00:06:30,130 --> 00:06:33,510 +هو الـ habit chain أيضًا ينطبق على ال lights زي ما + +76 +00:06:33,510 --> 00:06:38,430 +قلنا وفي النهاية بيكونونها ال IGF هي زي ما تشوفين + +77 +00:06:38,430 --> 00:06:45,290 +ال VDG هذه برضه two clones of cell ماشي VDG تكون + +78 +00:06:45,290 --> 00:06:49,570 +مرتبط مع ال constant VDG مع ال constant هي ال VDG + +79 +00:06:49,570 --> 00:06:54,330 +recombination رقم واحد ارتبط مع ال constant وهذا + +80 +00:06:54,330 --> 00:06:58,210 +رقم اتنين ارتبط مع ال constant هذا بيستكون ليه + +81 +00:06:58,210 --> 00:07:05,610 +antibodyمختلف في ال specificity عن هذا ال antibody + +82 +00:07:05,610 --> 00:07:08,590 +لكن يجب أن تلاحظ ان ال constant region لم تتأثر + +83 +00:07:08,590 --> 00:07:13,430 +هنا وبالتالي ال two antibodies are the same + +84 +00:07:13,430 --> 00:07:21,230 +classes لكن ال specificity بتختلف هنا هذه واحدة + +85 +00:07:21,230 --> 00:07:27,410 +حمرة وهذه واحدة خارقة يعني النواتج هذه العملية انه + +86 +00:07:27,410 --> 00:07:32,210 +ممكن يكون oneone antibody with different + +87 +00:07:32,210 --> 00:07:37,850 +specificity with ايش؟ ممكن تولدلي one antibody زي + +88 +00:07:37,850 --> 00:07:41,850 +ال IGM مابتطلع على سطح البيلينفسان لكن with + +89 +00:07:41,850 --> 00:07:44,790 +different specificity في كل مرة بتصفر تصفيتها + +90 +00:07:44,790 --> 00:07:50,210 +مختلفة فبديني antibody مختلف على سطح الخلية يعني + +91 +00:07:50,210 --> 00:07:51,530 +ال PCR بيختلف + +92 +00:07:54,530 --> 00:07:57,690 +كل واحد منهم يتجار بشكل مختلف عن الـ Antigen + +93 +00:07:57,690 --> 00:08:08,670 +Specificity الوظائف + +94 +00:08:08,670 --> 00:08:12,090 +البيولوجية + +95 +00:08:12,090 --> 00:08:14,910 +و الفيزيائية هي نفس الشيء + +96 +00:08:20,730 --> 00:08:24,450 +Source of diversity اتفقنا على انه ما ده هي فى عدد + +97 +00:08:24,450 --> 00:08:30,010 +جينات فى كل segment مسئولة عن الهيبوتشين وعن + +98 +00:08:30,010 --> 00:08:36,790 +الكابا وطبعا نفس الحكاية بالنسبة لل TCR Alpha و + +99 +00:08:36,790 --> 00:08:41,510 +Beta طبعا حاصل ضربهم هذا بيقدى ال generation of + +100 +00:08:41,510 --> 00:08:46,750 +diversityأيه بيصير الميكانيزم كcombinatorial + +101 +00:08:46,750 --> 00:08:50,990 +diversity ترتبط ال VD مع J في ال amino global + +102 +00:08:50,990 --> 00:08:54,430 +بيوصل لعدد ل تقريبا مليون تقريبا مليون تقريبا + +103 +00:08:54,430 --> 00:08:57,890 +مليون تقريبا مليون تقريبا مليون تقريبا مليون + +104 +00:08:57,890 --> 00:08:57,890 +تقريبا مليون تقريبا مليون تقريبا مليون تقريبا + +105 +00:08:57,890 --> 00:08:58,230 +مليون تقريبا مليون تقريبا مليون تقريبا مليون + +106 +00:08:58,230 --> 00:08:58,430 +تقريبا مليون تقريبا مليون تقريبا مليون تقريبا + +107 +00:08:58,430 --> 00:09:01,010 +مليون تقريبا مليون تقريبا مليون تقريبا مليون + +108 +00:09:01,010 --> 00:09:08,730 +تقريبا مليون تقريبا مليون تقريبا + +109 +00:09:08,730 --> 00:09:12,510 +مليون + +110 +00:09:12,510 --> 00:09:20,020 +تبنما بالمجمل عددها مهول في الجسم طيب عرفنا خصائص + +111 +00:09:20,020 --> 00:09:22,600 +الـ B lymphocytes الخطوة اللي بعدها زي ما قلنا + +112 +00:09:22,600 --> 00:09:25,600 +بتطلع من الـ bone marrow بتروح عليش ال peripheral + +113 +00:09:25,600 --> 00:09:30,440 +lymphoid organs يعني بتسير ماتشور خلصت من ال bone + +114 +00:09:30,440 --> 00:09:37,820 +marrow و يوم ما تسير ماتشور بتلف + +115 +00:09:37,820 --> 00:09:43,900 +homing phenomena بتظل تلف ما بينما بين ال blood و + +116 +00:09:43,900 --> 00:09:47,660 +ال secondary lymphoid organs looking for antigen + +117 +00:09:47,660 --> 00:09:50,640 +إذا لم تصادف ال antigen it will die through + +118 +00:09:50,640 --> 00:09:56,080 +apoptosis طيب stages of B cell development اتفقنا + +119 +00:09:56,080 --> 00:10:00,200 +انه الخلية لازم ياشت صادف antigen فهي هيوم تصادف + +120 +00:10:00,200 --> 00:10:04,600 +antigen بيصير ال heclonal expansion طبعا بيصير + +121 +00:10:04,600 --> 00:10:08,300 +activation differentiation و proliferationوبالتالي + +122 +00:10:08,300 --> 00:10:16,160 +بيحصل فيه Clonal Expansion طيب، شو اللي بيحصل عشان + +123 +00:10:16,160 --> 00:10:20,080 +تتنشط وتعملنا لـ Clonal Expansion هذا؟ يعني الـ + +124 +00:10:20,080 --> 00:10:23,440 +Naive B cell encounter أنتجن، على فكرة يوم ما تمسك + +125 +00:10:23,440 --> 00:10:27,220 +في الانتجن، بيعتبروها survival signal يعني هي + +126 +00:10:27,220 --> 00:10:33,130 +إشارة النجاة بالنسبة للخليةلأن جماعة صادفة antigen + +127 +00:10:33,130 --> 00:10:38,250 +to die فيوم ما تصادف ال antigen بتتنشط و بتعمر في + +128 +00:10:38,250 --> 00:10:45,530 +الجسم فهي ال IP lymphocytes على سطح IGM و IGD مسكت + +129 +00:10:45,530 --> 00:10:49,210 +في مين؟ مسكت في antigen طبعا يوم ما تمسك في ال + +130 +00:10:49,210 --> 00:10:54,230 +antigen بتقدمه طبعا تاخده تعمله processing ثم بيع + +131 +00:10:55,040 --> 00:10:59,080 +بتطلع مرتبط بالـ MSC موليكيول على سطحها وبتقدم + +132 +00:10:59,080 --> 00:11:05,240 +لمين لـ T-Helper Cell بتقدم لمين لـ T-Helper Cell + +133 +00:11:05,240 --> 00:11:09,140 +وليش T-Helper Cell اللي هي CD4 لإنه الـ B + +134 +00:11:09,140 --> 00:11:13,940 +-Lymphocyte على سطحها MSC Class II موليكيول كي + +135 +00:11:13,940 --> 00:11:18,580 +بتهم العملية يعني هي الـ B-Lymphocyte مسكت في + +136 +00:11:18,580 --> 00:11:25,580 +أنتجن B Cell Recognition of Native Proteinمشي + +137 +00:11:25,580 --> 00:11:31,260 +برتبط بالـ Cognitive Antigen الـ ABCR برتبط بإيش؟ + +138 +00:11:31,260 --> 00:11:38,740 +بأقرب اللي هو الـ Antigen القريب منه شو بيصير في + +139 +00:11:38,740 --> 00:11:42,360 +هذه الحالة؟ قالوا بقت ما نمسك في الـ Receptor + +140 +00:11:42,360 --> 00:11:48,020 +بيصير فيه Endocytosis يعني بدخل في داخل الخلية و + +141 +00:11:48,020 --> 00:11:52,490 +في داخل الخلية الـ Antigen is processedوزي ما قلنا + +142 +00:11:52,490 --> 00:11:55,710 +لكوا بيطلع مرتبط بلامة C class 2 موليكيول على سطح + +143 +00:11:55,710 --> 00:12:00,110 +الخلية وبالتالي ببساطة ال mesel act as a classical + +144 +00:12:00,110 --> 00:12:04,670 +antigen presenting cell بتقدمه لمين ل T helper + +145 +00:12:04,670 --> 00:12:11,050 +cell once طبعا العملية هذه صارت بيصير في + +146 +00:12:11,050 --> 00:12:14,610 +activation طبعا stimulation ل T cell activation + +147 +00:12:14,610 --> 00:12:19,170 +تبدأ عملية تنشيط T lymphocyte لكن عملية التنشيط + +148 +00:12:19,170 --> 00:12:27,820 +تحتاج إلى أيش؟إلى مراحل هى ارتباط ما بين بيسل وما + +149 +00:12:27,820 --> 00:12:32,840 +بين تيسل وشايفين السهمين هدول؟ شو بيعني و المربع + +150 +00:12:32,840 --> 00:12:38,920 +هذا؟ يعني ان الخليتين عشان يتنشطوا بحتاجوا الى two + +151 +00:12:38,920 --> 00:12:44,920 +signal الأولانى ارتباط ال TCR بالانتجن اللى ماسك + +152 +00:12:44,920 --> 00:12:53,270 +فى مين؟ بال MHC moleculeو بيسموها ايش ال first + +153 +00:12:53,270 --> 00:12:57,510 +signal طبعا في هذه ال first signal بيكون ال CD4 + +154 +00:12:57,510 --> 00:13:01,190 +مسك في ال MSC موليكيول ال CD4 اللي جاعد على مين؟ + +155 +00:13:01,190 --> 00:13:04,290 +على سطح ال D-Lymphocyte ومسك في مين؟ في ال MSC + +156 +00:13:04,290 --> 00:13:07,270 +Class II موليكيول اللي جاعد على سطح ال D + +157 +00:13:07,270 --> 00:13:11,510 +-Lymphocyte هذه بيعتبروها first signal هذا هيلكنها + +158 +00:13:11,510 --> 00:13:15,610 +غير كافية لتمشيط الـ T-Lymphocyte فبتروحوا الـ T + +159 +00:13:15,610 --> 00:13:20,530 +-Lymphocyte عاملة أو مرتبطة من خلال Co-Stimulatory + +160 +00:13:20,530 --> 00:13:25,070 +Reaction وإحنا سابقا قلنا إنه يوم الخلية تمسك + +161 +00:13:25,070 --> 00:13:30,270 +Foreign Antigen بصير فيه Co-Stimulation لكن لو الـ + +162 +00:13:30,270 --> 00:13:34,930 +B-Lymphocyte ماسكة على سطح الأمعد C-molecule الـ + +163 +00:13:34,930 --> 00:13:38,810 +Self-antigen لا تتولد الـ Co-Stimulation بسبب الـ + +164 +00:13:38,810 --> 00:13:43,220 +Hash بس لها Down Regulation على طولفهنا صار في up + +165 +00:13:43,220 --> 00:13:45,800 +-regulation للـ co-stimulator من الكليون اللي هي + +166 +00:13:45,800 --> 00:13:55,360 +CD28 بترتبط ب B7 ماشي بعد هيك تينفوسايت بتتنشط + +167 +00:13:55,360 --> 00:14:01,870 +فبتكون و هي عاملة حاجتين ام طلع CD40 لجدعشان يرتبط + +168 +00:14:01,870 --> 00:14:06,510 +في مين هذا هو الـ CD40 اللي موجود على سطح مين الـ + +169 +00:14:06,510 --> 00:14:12,750 +B lymphocyte و بتطلع cytokine بتفرز + +170 +00:14:12,750 --> 00:14:20,910 +حاجتين CD40 لجند و cytokine شو بيصير بعد هيك رقم + +171 +00:14:20,910 --> 00:14:25,810 +تلاتة جاله CD40 بيمسك في CD40 لجند تقوى الرابطة + +172 +00:14:25,810 --> 00:14:30,150 +تقوى الرابطة ضروري ليه تنشيط الـ B lymphocyte نعم + +173 +00:14:30,920 --> 00:14:36,120 +بس في وجود الـ cytokine الـ EH اللي أفرزتها الـ T + +174 +00:14:36,120 --> 00:14:39,280 +-Helper Cell طبعا في هذه الحالة بيصير فيه EH + +175 +00:14:39,280 --> 00:14:42,540 +activation بمعنى انه بيصير فيه proliferation و + +176 +00:14:42,540 --> 00:14:47,120 +differentiation و بيصير فيه clonal expansion لهذه + +177 +00:14:47,120 --> 00:14:51,120 +الخلية اللي بتتنشط و بتتحول ل B cell و ده يصار + +178 +00:14:51,120 --> 00:14:56,520 +تتطلع انها EH antibody هي antibody-secreting cell + +179 +00:14:56,520 --> 00:15:01,860 +سموها antibody-secreting cellبنشوف ايش اللي بيصير + +180 +00:15:01,860 --> 00:15:05,500 +يبقى صار فيه عملية activation هي activated للبيه + +181 +00:15:05,500 --> 00:15:11,120 +الانفسايد نشطة عملية Clonal Expansion وكان عملية + +182 +00:15:11,120 --> 00:15:15,900 +ال Clonal Expansion هم متفاقينإن كل خلية عبارة عن + +183 +00:15:15,900 --> 00:15:18,520 +عدد من خلايا الـ B lymphocyte اللي موجودة في الجسم + +184 +00:15:18,520 --> 00:15:23,300 +وزي ما تشايفين هم ألوان مختلفة لأنه على سطح لأن ال + +185 +00:15:23,300 --> 00:15:27,800 +specificity تبعتهم مختلفة specificity تبعت مين كل + +186 +00:15:27,800 --> 00:15:32,120 +ال PCR على سطحها بيرتبط و ده different antigen it + +187 +00:15:32,120 --> 00:15:36,960 +has unique specificity فلو شفنا مثلا على سبيل + +188 +00:15:36,960 --> 00:15:44,590 +المثال خلية صادفت تمسك في antigenالتي ليست محددة + +189 +00:15:44,590 --> 00:15:50,870 +لها وليس هناك ارتباط لكن يوم يطلع الانتجن محدد لـ + +190 +00:15:50,870 --> 00:15:57,870 +PCR اللي موجودة هتمسك فيه طبعا في نظريتين بتقولوا + +191 +00:15:57,870 --> 00:16:00,590 +نظرية الأولى بتقول ان ال white BCG اللي بتدور على + +192 +00:16:00,590 --> 00:16:03,840 +الانتجن وفي بعض مراتبعض المراجعين يقولون ان + +193 +00:16:03,840 --> 00:16:28,760 +الانتيجين يبحث عن خلق + +194 +00:16:28,760 --> 00:16:30,320 +خلق محدد لعينه لعينه لعينه لعينه لعينه لعينه لعينه + +195 +00:16:30,320 --> 00:16:30,580 +لعينه لعينه لعينه لعينه لعينه لعينه لعينه لعينه + +196 +00:16:30,580 --> 00:16:30,580 +لعينه لعينه لعينه لعينه لعينه لعينه لعينه لعينه + +197 +00:16:30,580 --> 00:16:30,580 +لعينه لعينه لعينه لعينه لعينه لعينه لعينه لعينه + +198 +00:16:30,580 --> 00:16:30,580 +لعينه لعينه لعينه لعينه لعينه لعينه لعينه لعينه + +199 +00:16:30,580 --> 00:16:30,580 +لعينه لعينه لعينه لعينه لعينه لعينه لعينه لعينه + +200 +00:16:30,580 --> 00:16:33,530 +لعينه لعفبصير فيه Clonal Expansion طب بعدها شو + +201 +00:16:33,530 --> 00:16:37,110 +بيصير؟ قالوا هذه الخلية بتطبس لها differentiation + +202 +00:16:37,110 --> 00:16:43,510 +و بتكون لنا antibody secreting cell ده هي عبارة عن + +203 +00:16:43,510 --> 00:16:47,370 +plasma cell اللي بتفرز لنا antibody و في ال acute + +204 +00:16:47,370 --> 00:16:52,770 +infection ال primary بتطلع لنا IgM IgM إيه؟ + +205 +00:16:52,770 --> 00:16:58,470 +antibody secreted antibody secreted cell و في نفس + +206 +00:16:58,470 --> 00:17:04,070 +الوقت تنقسم و بتديني كماناللي هو Memory Cell دتني + +207 +00:17:04,070 --> 00:17:07,510 +ايه؟ Factor Cell ودتنا ايه؟ Memory Cell و ال + +208 +00:17:07,510 --> 00:17:10,690 +Memory Cell اللي ابنى هنعرفها هي عبارة عن + +209 +00:17:10,690 --> 00:17:16,130 +Quiescent Form of B of Plasma Cell Of إيش؟ Of + +210 +00:17:16,130 --> 00:17:21,230 +Plasma Cell اللي دوري ممكن تتنشط وب high affinity + +211 +00:17:21,230 --> 00:17:28,950 +لإيش؟ ل ال antigen انو antigen اللي أصلا مسكت فيه + +212 +00:17:28,950 --> 00:17:34,500 +ال B lymphocyte من الأولتا هي ال memory cell + +213 +00:17:34,500 --> 00:17:39,260 +يتكوّن من أكتف سل لينفوسايت تختار من memory cell + +214 +00:17:39,260 --> 00:17:44,720 +لفكتور سل ال memory cell هي برعنة من نييف + +215 +00:17:44,720 --> 00:17:48,700 +لينفوسايت خلية أول مرة بتشوف الانتجن as a result + +216 +00:17:48,700 --> 00:17:53,040 +of antigen exposure وبتقعد just for years in a + +217 +00:17:53,040 --> 00:17:57,780 +quiescent state في وضع خامل في وضع ساكن سكون + +218 +00:18:00,350 --> 00:18:10,350 +بتنشط بسرعة فظيعة تتنشط بسرعة + +219 +00:18:10,350 --> 00:18:13,310 +فظيعة تتنشط بسرعة فظيعة تتنشط بسرعة فظيعة تتنشط + +220 +00:18:13,310 --> 00:18:13,430 +بسرعة فظيعة تتنشط بسرعة فظيعة تتنشط بسرعة فظيعة + +221 +00:18:13,430 --> 00:18:13,990 +تتنشط بسرعة فظيعة تتنشط بسرعة فظيعة تتنشط بسرعة + +222 +00:18:13,990 --> 00:18:15,990 +فظيعة تتنشط بسرعة فظيعة تتنشط بسرعة فظيعة تتنشط + +223 +00:18:15,990 --> 00:18:19,030 +بسرعة فظيعة تتنشط بسرعة فظيعة تتنشط بسرعة فظيعة + +224 +00:18:19,030 --> 00:18:26,770 +تتنشط بسرعة فظيعة تتنشط بسرعة فظيعة تتنفي الـ + +225 +00:18:26,770 --> 00:18:30,150 +Primary Immune Response كما تشاهدون نحن نعرف في + +226 +00:18:30,150 --> 00:18:33,170 +مرحلة مخادرة السابقة حكينا على ان ال Primary + +227 +00:18:33,170 --> 00:18:37,350 +Immune Response عندما يدخل الانتيجن ال Primary + +228 +00:18:37,350 --> 00:18:40,190 +Immune Response يمر في عدة مراحل أول مرحلة ال lag + +229 +00:18:40,190 --> 00:18:42,970 +phase ثم ال exponential phase اللي بيصير فيه + +230 +00:18:42,970 --> 00:18:45,590 +activation للميليم فسايت و generation و antibody + +231 +00:18:45,590 --> 00:18:50,210 +ثم ال steady أو ال plateau phase وده عبارة عن + +232 +00:18:50,210 --> 00:18:55,730 +phase بتتساوى فيه اللي هو ال generation و antibody + +233 +00:18:56,290 --> 00:19:03,290 +والـ dying of antigen ثم بيصير فيه ال .. ال .. ال + +234 +00:19:03,290 --> 00:19:08,850 +decline لل care لإنه خلاص بتشير الخلايا أو ال + +235 +00:19:08,850 --> 00:19:14,750 +antibody اللي موجودة أكتر بكثير من مين من ال + +236 +00:19:14,750 --> 00:19:19,570 +antigen اللي موجود طبعا تقعد بلازم سيلف البنمرغ و + +237 +00:19:19,570 --> 00:19:22,450 +بتدخل تفرز و بتفرز على طول كمية كبيرة من ال + +238 +00:19:22,450 --> 00:19:26,390 +antibody ليش؟ ليه بشكل المناعة بعد هيك؟في الـ + +239 +00:19:26,390 --> 00:19:30,230 +secondary طبعاً بيكون faster و more potent زي ما + +240 +00:19:30,230 --> 00:19:36,170 +اتفقنا نفسي لحكاية لكن ايش بيكون once the + +241 +00:19:36,170 --> 00:19:39,190 +infection is repeated by the same antigen بيصير + +242 +00:19:39,190 --> 00:19:41,970 +فيه secondary بس زي ما انتوا شايفين في ال + +243 +00:19:41,970 --> 00:19:44,670 +secondary ال antibody اتغير لأنه صار في class + +244 +00:19:44,670 --> 00:19:54,930 +switching وتكون IGG بدل IGA من وصفاتهIt's faster + +245 +00:19:54,930 --> 00:19:59,570 +ال secondary زي ما انتوا شايفين ال face واحد لثلاث + +246 +00:19:59,570 --> 00:20:05,490 +أيام في ال primary من خمسة لعشرة it's stronger ال + +247 +00:20:05,490 --> 00:20:08,910 +peak response في ال primary small لكن في ال ash + +248 +00:20:08,910 --> 00:20:13,950 +secondary it's larger ال antibody is more specific + +249 +00:20:13,950 --> 00:20:17,650 +more ash specific و في نفس الوقت يعني له high + +250 +00:20:17,650 --> 00:20:21,970 +affinity و في نفس الوقت صار فيه ال class watching + +251 +00:20:21,970 --> 00:20:30,260 +phenomenonطيب يبقى هدا هي صار في إيش صار في نوع + +252 +00:20:30,260 --> 00:20:33,540 +تالت من إيش ال activation بالاحتمالات أما antibody + +253 +00:20:33,540 --> 00:20:36,760 +-secreting in a vector cell و أما memory cell و + +254 +00:20:36,760 --> 00:20:41,440 +أما صار في class switching once the infection is + +255 +00:20:41,440 --> 00:20:46,060 +repeated و ال class switching برضه أحنا حكينا فيها + +256 +00:20:46,060 --> 00:20:49,320 +قبل هيك أن ال wheel lymphocyte is not committed to + +257 +00:20:49,320 --> 00:20:54,590 +produce one single immunoglobulin foreverوإنما + +258 +00:20:54,590 --> 00:20:58,590 +ممكن هذا الـ Antibody يتغير بس شوفوا هنا .. كيف ال + +259 +00:20:58,590 --> 00:21:02,190 +team بتتغير؟ طبعا هي في البداية بتطلع IGM لأن أول + +260 +00:21:02,190 --> 00:21:07,370 +constant gene مرتبط فيها هو الـ Mu chain فبتطلع Mu + +261 +00:21:07,370 --> 00:21:11,290 +وDelta ومافيش بينهم repeated sequence وبالتالي + +262 +00:21:11,290 --> 00:21:14,930 +اتنين بيطلعوا مع بعض لكن من الباقى في repeated + +263 +00:21:14,930 --> 00:21:19,790 +sequence ومنها switch region فلو .. لو صارت class + +264 +00:21:19,790 --> 00:21:24,930 +switching شو اللي بيصير؟طبعا في البداية primary + +265 +00:21:24,930 --> 00:21:30,750 +اتمنى انه IGN يوم مايصير فيه class switching شوفوا + +266 +00:21:30,750 --> 00:21:38,750 +ايش اللي بيصير جالو ال DNA بلف لفة أو لفتين طبعا + +267 +00:21:38,750 --> 00:21:46,390 +هنا متى مالف بيصير عملية ايش اللي هو ال delta و ال + +268 +00:21:46,390 --> 00:21:53,040 +ميو بنقطعه by restriction enzymeو ال variable + +269 +00:21:53,040 --> 00:21:56,740 +region بيصير في هذه الحالة شبك مع الجامعة فمين + +270 +00:21:56,740 --> 00:22:03,300 +اللي بيطلع لل antipathy في هذه الحالة IGG بس بدى + +271 +00:22:03,300 --> 00:22:06,180 +تلاحظوا في ال class switching فنومنات ان التغير + +272 +00:22:06,180 --> 00:22:09,520 +اللي هو بيصير التغير بيصير في ال constant region + +273 +00:22:09,520 --> 00:22:13,180 +هي تحولت من ال mu ل جامعة طب و ال variable + +274 +00:22:17,560 --> 00:22:21,640 +الـ Antibody class هو اللي اتغير، الـisotype هو + +275 +00:22:21,640 --> 00:22:25,920 +اللي اتغير، لكن ال specificity دلت مش the same + +276 +00:22:25,920 --> 00:22:31,820 +فأول كان فينا IgM، صار IgG، لكن ال both are + +277 +00:22:31,820 --> 00:22:33,640 +specific for the same antigen + +278 +00:22:37,100 --> 00:22:40,860 +الـ Class-switching Phenomena تشرح لماذا الـ IgM + +279 +00:22:40,860 --> 00:22:44,300 +لا يتم رؤيه عن طريق الـ Re-exposure لـ الانتجين. + +280 +00:22:44,900 --> 00:22:48,740 +هكذا نفسر لماذا لا يتم رؤيه عن طريق الـ IgM مرة + +281 +00:22:48,740 --> 00:22:58,720 +أخرى. طبعا الـ IgM هو عبارة عن PCR على سطح الخلية + +282 +00:22:58,720 --> 00:23:03,600 +يوم ما يرتبط بالانتجين الـ Cognitive Antigen تابعه + +283 +00:23:03,950 --> 00:23:08,410 +طبعاً بيحصل في activation وsecretion لـ IgM لكن + +284 +00:23:08,410 --> 00:23:13,850 +هذا الـ IgM ممكن يتحول إلى IgG يوم ما ينمسك فيه + +285 +00:23:13,850 --> 00:23:18,630 +the same antigen وبالتالي ممكن يدينا IgG، IgA أو + +286 +00:23:18,630 --> 00:23:23,870 +IgE هذه ال class switching فنومنا نرجو أن تكونوا + +287 +00:23:23,870 --> 00:23:28,590 +ممكن استفدتم من هذه المحاضرة و + +288 +00:23:36,450 --> 00:23:37,010 +عشان الله + diff --git a/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/jdGOJ1cxTIc_postprocess.srt b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/jdGOJ1cxTIc_postprocess.srt new file mode 100644 index 0000000000000000000000000000000000000000..bc93fd9ff4bb0746fd3dc2b0e8fb7c41ca1ec508 --- /dev/null +++ b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/jdGOJ1cxTIc_postprocess.srt @@ -0,0 +1,1836 @@ +1 +00:00:01,790 --> 00:00:06,030 +بسم الله الرحمن الرحيم اليوم ان شاء الله هنحكي في + +2 +00:00:06,030 --> 00:00:11,050 +محاضرة جديدة بعنوان Transplantation Immunology + +3 +00:00:11,050 --> 00:00:16,210 +هنتعرف فيها على definitions Transplantation + +4 +00:00:16,210 --> 00:00:21,650 +Antigen Antigen Presentation Recognition Mechanism + +5 +00:00:21,650 --> 00:00:22,290 +of Rejection + +6 +00:00:34,120 --> 00:00:40,800 +طبعا هذه صورة كريكاتيرية بتحكي على how much it's + +7 +00:00:40,800 --> 00:00:46,980 +easy transplantation process طبعا مش بهذه الصورة و + +8 +00:00:46,980 --> 00:00:55,160 +انما هي كريكاتيرية للضحك بتعرفين ان ال tissue and + +9 +00:00:55,160 --> 00:01:01,360 +organs في الجسم يحتووا على antigens اضافة لأن ال + +10 +00:01:17,940 --> 00:01:21,460 +التطور العلمي والاستخدام من مجموعات مختلفة من + +11 +00:01:21,460 --> 00:01:22,080 +مجموعات مختلفة من مجموعات مختلفة من مجموعات مختلفة + +12 +00:01:22,080 --> 00:01:22,160 +مجموعات مختلفة من مجموعات مختلفة من مجموعات مختلفة + +13 +00:01:22,160 --> 00:01:22,260 +مختلفة من مجموعات مختلفة من مجموعات مختلفة من + +14 +00:01:22,260 --> 00:01:24,500 +مجموعات مختلفة من مجموعات مختلفة من مجموعات مختلفة + +15 +00:01:24,500 --> 00:01:32,440 +من مجموعات مختلفة من + +16 +00:01:36,710 --> 00:01:40,750 +transplantation by definition هي transplant or + +17 +00:01:40,750 --> 00:01:46,050 +graft هو عبارة عن نقل transfer of living cells or + +18 +00:01:46,050 --> 00:01:50,010 +tissue and organ from one part of the body to + +19 +00:01:50,010 --> 00:01:54,250 +another أو from one individual to another يعني نقل + +20 +00:01:54,250 --> 00:01:58,370 +من شخص إلى آخر وهذه هي العلاقات + +21 +00:02:08,110 --> 00:02:13,190 +Tissue or organ + +22 +00:02:13,190 --> 00:02:16,770 +from one + +23 +00:02:16,770 --> 00:02:22,370 +individual to the same individual سموها + +24 +00:02:22,370 --> 00:02:27,030 +autographed and it's usually not rejected ثم قال + +25 +00:02:27,030 --> 00:02:30,470 +له graft وهو عبارة عن نقل + +26 +00:02:47,360 --> 00:02:52,860 +النوع التالت اللي هو نقل from two different + +27 +00:02:53,360 --> 00:02:57,240 +individual of different species يعني زي ما انتوا + +28 +00:02:57,240 --> 00:03:01,280 +شايفين from animal to human و بيسموها xenograph + +29 +00:03:01,280 --> 00:03:07,560 +and it's also different and usually rejected ال + +30 +00:03:07,560 --> 00:03:12,320 +Autograph غالبا بتصير زي ما انتوا شايفين اهم مثال + +31 +00:03:12,320 --> 00:03:16,360 +اللي مضروب يعبر عن عملية مقل شعر from one person + +32 +00:03:16,360 --> 00:03:22,500 +to his ownاللي هو skin وهي مراحل عملية ال + +33 +00:03:22,500 --> 00:03:27,960 +autografting ل .. ل .. ل .. ل .. ل .. acceptance + +34 +00:03:27,960 --> 00:03:34,020 +طبعا بتتم عملية الزراعة في عملية ال epidermis ده + +35 +00:03:34,020 --> 00:03:42,140 +هي و بدأ يصير في عملية vascularization في المنطقة + +36 +00:03:42,140 --> 00:03:47,590 +يعني وصول الدم وترويتها لهذه المنطقةثم بيصير فيه + +37 +00:03:47,590 --> 00:03:52,810 +عملية ال healing process ثم بعد ذلك بيصير عملية ال + +38 +00:03:52,810 --> 00:03:57,690 +cleaning اللي هو resolution او اتمام لعملية ال + +39 +00:03:57,690 --> 00:04:02,590 +healing process غالبا بتتم ال auto grafting على + +40 +00:04:02,590 --> 00:04:06,950 +شكل skin graft or bone marrow transplantation or + +41 +00:04:06,950 --> 00:04:13,270 +even hair allograft اتفقنا على انه transfer of + +42 +00:04:13,270 --> 00:04:20,280 +organsكما تشاهدون هذا مانجوله إيدين بس زي ما قولنا + +43 +00:04:20,280 --> 00:04:26,080 +transplantation has become quite common كثير ويلها + +44 +00:04:26,080 --> 00:04:29,940 +many many applications هذا ال xenograft نقلها زي + +45 +00:04:29,940 --> 00:04:34,220 +ما قولنا from animal to human بسموها xenografting + +46 +00:04:34,220 --> 00:04:42,240 +يعني from two different species طبعا هذا نتيجتهش + +47 +00:04:42,240 --> 00:04:45,520 +نتيجة النقص الشديد في عملية نقضة + +48 +00:04:53,320 --> 00:04:58,660 +لغاية الآن with limited success طبعا ال immune + +49 +00:04:58,660 --> 00:05:02,720 +system على طول will reject the transplanted organ + +50 +00:05:02,720 --> 00:05:09,420 +زي ما انتوا شايفين rejection of heart بيبدأ أحمر + +51 +00:05:09,420 --> 00:05:13,340 +وينتقل في النهاية للون الأسود دليل على انه تمت + +52 +00:05:13,340 --> 00:05:17,820 +عملية قتل هذا ال organ بتتم العملية القتل اللي هو + +53 +00:05:17,820 --> 00:05:21,900 +في الhyperactiveإذا كان فيش good matching within + +54 +00:05:21,900 --> 00:05:26,980 +fifteen to twenty minutes دور بنقول die يعني أثناء + +55 +00:05:26,980 --> 00:05:32,160 +العملية ممكن يعرف الطبيب انه عملية نجحت ولا لم + +56 +00:05:32,160 --> 00:05:42,440 +تنجح ال + +57 +00:05:42,440 --> 00:05:42,540 +.. + +58 +00:06:00,040 --> 00:06:09,500 +الانتجين الانتجين الانتجين الانتجين الانتجين + +59 +00:06:09,500 --> 00:06:14,240 +الانتجين + +60 +00:06:14,240 --> 00:06:21,220 +الانتجين + +61 +00:06:21,220 --> 00:06:24,000 +الانتجين الانتجين الانتجين الانتجين الانتجين + +62 +00:06:24,000 --> 00:06:24,100 +الانتجين الانتجين الانتجين الانتجين الانتجين + +63 +00:06:24,100 --> 00:06:26,900 +الانتجين الانتجين الانتجين الانتجين الانتجين + +64 +00:06:26,900 --> 00:06:27,140 +الانتجين الانتجين الانتجين الانتجين الانتجين + +65 +00:06:27,140 --> 00:06:27,660 +الانتجين الانتجين الانتجين الانتجين الانتجين + +66 +00:06:27,660 --> 00:06:31,750 +الانتجين الانتجين الانتجمعايير الـ MHC بين المدير + +67 +00:06:31,750 --> 00:06:42,550 +والمستخدم يعني عاملاً هما مختلفين ومعاييرها + +68 +00:06:42,550 --> 00:06:47,190 +يجب أن تكون فعلة لتقليل فرصة الانتجان طبعاً + +69 +00:06:47,190 --> 00:06:50,790 +بيسموها HLA اللي هو human leukocyte antigen في + +70 +00:06:50,790 --> 00:06:55,640 +الهيومان هناك اتسابقين class one و class twoو كنا + +71 +00:06:55,640 --> 00:06:59,080 +بنعرف ال expression of a class of MSC molecule can + +72 +00:06:59,080 --> 00:07:03,700 +be upregulated by its chemistry و طبعا عارفين + +73 +00:07:03,700 --> 00:07:11,980 +تسمياتها class 1 بيسموها HLAE و B و C و class 2 + +74 +00:07:11,980 --> 00:07:18,640 +بيسموها DRDQDB + +75 +00:07:18,640 --> 00:07:29,310 +و هكذاالـ tissue typing بتتم من خلال عدة فحوصات + +76 +00:07:29,310 --> 00:07:32,850 +الفحوصات + +77 +00:07:32,850 --> 00:07:36,330 +قد تكون serological يعني بمعنى تعتمد على antibody + +78 +00:07:36,330 --> 00:07:44,130 +و بتتم عملية اللي هو ال actually typing by using + +79 +00:07:44,130 --> 00:07:51,060 +panel of antibodyمثل الـ HLA-typing هذه هي panel + +80 +00:07:51,060 --> 00:07:55,960 +of HLA-specific antisera or monoclonal antibody is + +81 +00:07:55,960 --> 00:08:00,760 +used to determine the phenotype of MHC antigen + +82 +00:08:00,760 --> 00:08:05,960 +expressed on the cell الفحث + +83 +00:08:05,960 --> 00:08:10,900 +التاني lymphocytic cytotoxicity طبعا في هذا الفحث + +84 +00:08:10,900 --> 00:08:20,170 +MHC-specific antibodyمع ال complement are used to + +85 +00:08:20,170 --> 00:08:24,190 +determine their ability to determine the + +86 +00:08:24,190 --> 00:08:27,630 +complement ability to damage the target cell طبعا + +87 +00:08:27,630 --> 00:08:32,930 +كنا بنعرف أنه إذا كان ال antibody ال antigen تبعه + +88 +00:08:32,930 --> 00:08:36,010 +موجود هيصير فيه antigen antibody complex و ال + +89 +00:08:36,010 --> 00:08:39,690 +reaction و تتنشط من خلال ال complement وبالتالي to + +90 +00:08:39,690 --> 00:08:44,530 +damage the cellinvolved in the reaction فإذا كان + +91 +00:08:44,530 --> 00:08:48,890 +cancer damaging معناته ال antigen موجود و احنا + +92 +00:08:48,890 --> 00:08:52,070 +بنعرف ال antibody لمين هدا ال antigen فبتالي بنقدر + +93 +00:08:52,070 --> 00:08:58,350 +نعمل matching و بنعرف من خلال ال lymphocyte of the + +94 +00:08:58,350 --> 00:09:01,270 +donor مع ال recipient are reacted with a panel of + +95 +00:09:01,270 --> 00:09:06,430 +antibody with specificity for a wide range of MHC + +96 +00:09:06,430 --> 00:09:12,140 +class 1 و 2 وبتالي بنتعرف علىطبعا ال complement + +97 +00:09:12,140 --> 00:09:18,720 +هتقتل هتعمل damaging و this will indicate that + +98 +00:09:18,720 --> 00:09:22,340 +antibody has reacted with the cell surface MHC + +99 +00:09:22,340 --> 00:09:29,280 +وبالتالي cell are positive for MHC الليل tissue + +100 +00:09:29,280 --> 00:09:35,020 +thriving هي using antibody against HLA في وجود ال + +101 +00:09:35,020 --> 00:09:43,480 +complement طبعاإذا كان ال donor يعني + +102 +00:09:43,480 --> 00:09:48,500 +ال compliment إذا ال cell die اتأبيره blue ده هو + +103 +00:09:48,500 --> 00:09:52,260 +التفاعل موجود لإن ال cell went from yoyo to die + +104 +00:09:52,260 --> 00:09:58,160 +تفاعل موجود على ال donor و على ال recipient mixed + +105 +00:09:58,160 --> 00:10:04,030 +leukocyte reactionفي هذه الفحص بتتم عملية بتعتمد + +106 +00:10:04,030 --> 00:10:13,410 +فيها على ال phenomenon اللي بتصير يوم يلتقي انتجين + +107 +00:10:13,410 --> 00:10:17,990 +بالياش بال legend تبعهم شو اللي بيصير انه بنخلط + +108 +00:10:17,990 --> 00:10:26,870 +lymphocytes from donor and recipient و بنعملهم + +109 +00:10:26,870 --> 00:10:30,330 +culturing both ماشي + +110 +00:10:32,390 --> 00:10:38,590 +وبالتالي يوم الـ donor cell will recognize the + +111 +00:10:38,590 --> 00:10:40,810 +antigen of the recipient وبالتالي هتعمل + +112 +00:10:40,810 --> 00:10:47,690 +proliferationليش لنفسها او لعكس نفسه ال recipient + +113 +00:10:47,690 --> 00:10:52,910 +هتعمل ال recognition للدونا انتيجين وبرضه تعمل + +114 +00:10:52,910 --> 00:10:56,970 +proliferative phenomena وبالتالي احنا ندمر على ال + +115 +00:10:56,970 --> 00:11:00,130 +proliferation صار فيه proliferation معناته فيه + +116 +00:11:00,130 --> 00:11:03,190 +reaction ما صار فيه proliferation معناته مافيش ايش + +117 +00:11:03,190 --> 00:11:09,030 +مافيش انتيجين مافيش reaction صار وبالتالي ال + +118 +00:11:09,030 --> 00:11:13,470 +proliferation ممكن نقيسه byby using fluorescent + +119 +00:11:13,470 --> 00:11:17,590 +dye or by using fluocytometry by using + +120 +00:11:17,590 --> 00:11:23,030 +fluocytometry ايه ال mixed lymphocyte reaction؟ + +121 +00:11:23,030 --> 00:11:28,710 +ريسبية مع دونر طبعا المفروض انه سيرفيس ال + +122 +00:11:28,710 --> 00:11:31,890 +proliferation فاذا في strong proliferation to high + +123 +00:11:31,890 --> 00:11:38,690 +incompatibility مافي تطابق اعتبرتها انتجن غريب + +124 +00:11:38,690 --> 00:11:42,860 +وتفاعلت مع صرفي بيوريسبونسكل مكان مافيش + +125 +00:11:42,860 --> 00:11:45,920 +proliferation معناته hundred percent compatibility + +126 +00:11:45,920 --> 00:11:51,000 +طبعا مافيش hundred percent compatibility types of + +127 +00:11:51,000 --> 00:11:58,080 +graft rejection antibody-mediated rejection وجاله + +128 +00:11:58,080 --> 00:12:00,620 +فيه نوعين بيعتمد على ال antibody ال hyper acute و + +129 +00:12:00,620 --> 00:12:05,300 +ال acute or delayed antibody-mediated rejection + +130 +00:12:05,300 --> 00:12:12,320 +فيه cellular و chronic rejectionأهم الـ matching + +131 +00:12:12,320 --> 00:12:15,740 +between donor and recipient to prevent rejection + +132 +00:12:15,740 --> 00:12:21,760 +طبعا هذا الكلام مش مظبوط ما بيعمل reduction لل + +133 +00:12:21,760 --> 00:12:29,360 +prevention لل rejection ولكن reduce rejection but + +134 +00:12:29,360 --> 00:12:32,700 +still there is a minor histocompatibility antigen + +135 +00:12:32,700 --> 00:12:41,430 +و probably these minorHistocompatibility antigen + +136 +00:12:41,430 --> 00:12:48,370 +هي عبارة عن Polymorphism موجودة بين Indigroves + +137 +00:12:48,370 --> 00:12:55,070 +which bind the peptides of antigen لكن احنا ما + +138 +00:12:55,070 --> 00:12:58,230 +بنقدر نعمل كمان matching لل Polymorphism اللى + +139 +00:12:58,230 --> 00:13:02,190 +موجودة فيهش في Indigroves وبالتالي في Anatomage + +140 +00:13:02,190 --> 00:13:08,610 +Polymorphism يعني صعب جدا ان اناوهذا بيؤدي إلى انه + +141 +00:13:08,610 --> 00:13:14,830 +كل ما زادت ال polymorphism كل ما قلت ال ash قل وقت + +142 +00:13:14,830 --> 00:13:19,130 +ال ash ال rejection عشان + +143 +00:13:19,130 --> 00:13:23,550 +هيك احنا مستخدم ال amino suppressive drug نقلل من + +144 +00:13:23,550 --> 00:13:29,550 +ال ash من ال rejection كيف + +145 +00:13:29,550 --> 00:13:32,130 +تتم عملية ال matching؟ جانا ال matching ناخد + +146 +00:13:32,130 --> 00:13:35,970 +finding a dollar بيشترك + +147 +00:13:36,480 --> 00:13:40,500 +في الـ HLA انتجين تعمل مع الـ recipient وبالتالي + +148 +00:13:40,500 --> 00:13:44,580 +بنقلل الانتجين الاختلافات اللي هو الاختلافات + +149 +00:13:44,580 --> 00:13:50,320 +لتختار + +150 +00:13:50,320 --> 00:13:55,420 +ذلك you have to match or to determineto identify + +151 +00:13:55,420 --> 00:13:59,640 +both donor and recipient antigen الان cross + +152 +00:13:59,640 --> 00:14:04,820 +-matching انه نعمل testing لسيرم of recipient for + +153 +00:14:04,820 --> 00:14:09,300 +antibody against the donor antigen اي cross-match + +154 +00:14:09,300 --> 00:14:14,880 +عادية وسهلة actually sensitization يعني exposure + +155 +00:14:14,880 --> 00:14:18,540 +to non self actually antigen can cause production + +156 +00:14:18,540 --> 00:14:21,880 +of actually directed antibody اي انسان اتعرض لها + +157 +00:14:22,400 --> 00:14:28,360 +اللي هو transplantation before يعني اتعرض + +158 +00:14:28,360 --> 00:14:31,820 +لانتيجينات غريبة قبل هيك هيكون انتيبودي لها هذه + +159 +00:14:31,820 --> 00:14:38,500 +الانتيجينات طبعا ال sensitization وتكون انتيبودي + +160 +00:14:38,500 --> 00:14:42,040 +عند + +161 +00:14:42,040 --> 00:14:48,380 +الإنسان different forانتجين مختلف ممكن ان الانسان + +162 +00:14:48,380 --> 00:14:52,900 +تتكوّن عنده من بلد ترانسيوجين من بلد ترانسيوجين او + +163 +00:14:52,900 --> 00:14:58,580 +ايضا من ترانسيوجين في الأطفال في الأطفال، آسف، ليس + +164 +00:14:58,580 --> 00:15:01,640 +الأطفال تشيو باتشيز تشيو باتشيز تشيو باتشيز تشيو + +165 +00:15:01,640 --> 00:15:03,120 +باتشيز تشيو باتشيز تشيو باتشيز تشيو باتشيز تشيو + +166 +00:15:03,120 --> 00:15:07,440 +باتشيز تشيو باتشيز تشيو باتشيز تشيو باتشيز تشيو + +167 +00:15:07,440 --> 00:15:12,340 +باتشيز تشيو باتشيز تشيو باتشيز تشيو باتشيز تشيو + +168 +00:15:12,340 --> 00:15:18,210 +باتشبينعرضه لأنتيجنات غريبة وبالتالي بيصير + +169 +00:15:18,210 --> 00:15:22,150 +sensitized يعني عنده antibody for these اللي هو + +170 +00:15:22,150 --> 00:15:27,070 +انتيجن هذا + +171 +00:15:27,070 --> 00:15:31,790 +بالنسبالي للأول انتيجن وهو الـHLA-A انتيجن اللي هو + +172 +00:15:31,790 --> 00:15:34,250 +the strongest HLA-A انتيجن النوع التاني من + +173 +00:15:34,250 --> 00:15:37,070 +الانتيجنات اللي باقي ونحتاجها لل transplantation + +174 +00:15:37,070 --> 00:15:42,110 +هو الـ ABO system وكنا بنعرف قضية الـ ABOهو كيفية + +175 +00:15:42,110 --> 00:15:46,370 +تكوين الانتجن بيكون فيه انها H انتجن وبنجلب ليش ل + +176 +00:15:46,370 --> 00:15:50,810 +A وB انتجن مثلا ال expression ل A وB انتجن وطبعا + +177 +00:15:50,810 --> 00:15:56,910 +بيكون ال blood group انتجن انواع مختلفة طبعا هذا + +178 +00:15:56,910 --> 00:16:01,930 +هو ال H انتجن بيتكوين وبعدين بنبني عليه ونكون A + +179 +00:16:01,930 --> 00:16:07,500 +انتجن او B انتجنالقانون الـ APU بين المستخدم + +180 +00:16:07,500 --> 00:16:11,540 +والمستخدم مهم جدًا لإيقاف اتفاق اتفاق مهم جدًا + +181 +00:16:11,540 --> 00:16:12,920 +لإيقاف اتفاق مهم جدًا لإيقاف اتفاق مهم جدًا لإيقاف + +182 +00:16:12,920 --> 00:16:14,140 +اتفاق مهم جدًا لإيقاف اتفاق مهم جدًا لإيقاف اتفاق + +183 +00:16:14,140 --> 00:16:14,880 +مهم جدًا لإيقاف اتفاق مهم جدًا لإيقاف اتفاق مهم + +184 +00:16:14,880 --> 00:16:20,320 +جدًا لإيقاف اتفاق مهم جدًا لإيقاف اتفاق مهم جدًا + +185 +00:16:20,320 --> 00:16:29,240 +لإيقاف اتفاق مهم جدًا لإيقاف اتفاق مهم + +186 +00:16:29,240 --> 00:16:34,480 +جدًا لإيRecipient preformed natural Anti-A, Anti-B + +187 +00:16:34,480 --> 00:16:37,600 +كما قلت لكوا بتكون already موجود ال Antibody و + +188 +00:16:37,600 --> 00:16:41,760 +التالي Transplantation of A B O Incompatible Organ + +189 +00:16:41,760 --> 00:16:46,900 +حيث يؤدي إلى ال Hyper Acute Rejection شو بيصير في + +190 +00:16:46,900 --> 00:16:51,500 +ال Hyper Acute Rejection ده هو يوم من نقل هي Zeno + +191 +00:16:51,500 --> 00:16:55,260 +Transplantation يعني مريب جدا من Animal لHumanبصير + +192 +00:16:55,260 --> 00:16:57,900 +فيه hyper acute rejection which means أنه فيه + +193 +00:16:57,900 --> 00:17:02,100 +antibody تكونت + +194 +00:17:02,100 --> 00:17:12,980 +طبعا for the foreign antigen وبالتالي اللي هو تم + +195 +00:17:12,980 --> 00:17:18,600 +التفاعل أو ضد هذا ال antigen طبعا فيه بيصير acute + +196 +00:17:18,600 --> 00:17:23,650 +vascular rejection وفي accommodationاللي ممكن + +197 +00:17:23,650 --> 00:17:37,070 +تنتقل الـ Cellular Thermocronic طبعا ال .. + +198 +00:17:37,070 --> 00:17:41,050 +العملية يعني أنا مابديش أخد في تفاصيلها وإنما هي + +199 +00:17:41,050 --> 00:17:45,000 +في البدايةبصير عملية first set rejection ثم second + +200 +00:17:45,000 --> 00:17:48,740 +set rejection ال first sex within set rejection + +201 +00:17:48,740 --> 00:17:56,120 +بيصير في خلال 14 يوم after اللي هو transplantation + +202 +00:17:56,120 --> 00:18:03,360 +و بيكون already تكون antibody لال foreign antigen + +203 +00:18:03,360 --> 00:18:08,100 +في ال hybrid acute اللي هو second set rejection + +204 +00:18:08,100 --> 00:18:11,710 +غالبا بيكون بيصير within minutes or hoursبيكون + +205 +00:18:11,710 --> 00:18:15,130 +اللي كان ال جن .. ال .. ال recipient عنده antibody + +206 +00:18:15,130 --> 00:18:19,270 +for the transplanted organ وبالتالي بيهاجموا على + +207 +00:18:19,270 --> 00:18:22,410 +طول وبيخلص .. بيتخلص منه + +208 +00:18:25,780 --> 00:18:29,040 +الشيء اللي بيصير، ده هي Performed Antibody صار فيه + +209 +00:18:29,040 --> 00:18:32,380 +IgG أو IgM ترتبط بالـ graft vascular الـ + +210 +00:18:32,380 --> 00:18:36,920 +endothelial cell وبتنشط complement وبالتالي بيصير + +211 +00:18:36,920 --> 00:18:44,120 +فيه اللي هو endothelial cell disformation طبعا في + +212 +00:18:44,120 --> 00:18:47,520 +هذه الحالة، بيصير في endothelial cell dysfunction + +213 +00:18:47,520 --> 00:18:52,280 +وإذا صار في endothelial cell dysfunctionبصير فيه + +214 +00:18:52,280 --> 00:18:55,960 +اللي هو loss of vascular integrity وزيادة في ال + +215 +00:18:55,960 --> 00:18:59,360 +expression of all surface molecules ثم cytokine + +216 +00:18:59,360 --> 00:19:02,620 +release لإنه sort of inflammatory reaction ثم + +217 +00:19:02,620 --> 00:19:05,500 +activation of clotting of the fibrillatic system + +218 +00:19:05,500 --> 00:19:10,180 +وزي ما انتوا شايفين endothelial disformation نشطة + +219 +00:19:10,180 --> 00:19:16,140 +platelet adherence اللي طبعا بالإضافة لإن هذه + +220 +00:19:16,140 --> 00:19:20,090 +بتعمل neutrophil activationمهم كل هذه العوامل + +221 +00:19:20,090 --> 00:19:24,930 +بتجتمع و بيصير فيها microvascular thrombosis و + +222 +00:19:24,930 --> 00:19:29,130 +Hemorrhage و Myocardial Necrosis ثم Graph + +223 +00:19:29,130 --> 00:19:37,110 +Destruction الـ Hyper Acute Rejection + +224 +00:19:37,110 --> 00:19:43,170 +و ده هو ال Antibody هاجم مباشرة اندثيليام الcell + +225 +00:19:43,170 --> 00:19:47,570 +عمل Vascular Endothelium Damageوبالتالي صار في ده + +226 +00:19:47,570 --> 00:19:53,170 +loss of integrity صار يطلع و إيدنا و طبعا في + +227 +00:19:53,170 --> 00:19:59,790 +activation لبليتلت فعملتاش clot formation و طبعا + +228 +00:19:59,790 --> 00:20:03,610 +ال bleeding micro hemorrhage ده بتطلع لإن هو في + +229 +00:20:03,610 --> 00:20:10,470 +loss of integrity فبصير برضه loss of blood و micro + +230 +00:20:10,470 --> 00:20:17,990 +hemorrhage وبالتالي بيصير في انفاركشن للأورجان + +231 +00:20:17,990 --> 00:20:28,090 +طبعا هي ال .. برضه صورة كاريكاترية بتبين انك بيصير + +232 +00:20:28,090 --> 00:20:32,610 +فيها graft rejectionوطبعا هي ال hyper acute + +233 +00:20:32,610 --> 00:20:36,790 +rejection of cardiac xenograft اللي على طول بيصير + +234 +00:20:36,790 --> 00:20:44,050 +فيه ايش اللي هو death for organ اللي صار فيه clot + +235 +00:20:44,050 --> 00:20:48,630 +formation وهي clot formation في كل السمر هذا أبرع + +236 +00:20:48,630 --> 00:20:51,510 +ان ال clot formation within the micro vasculature + +237 +00:20:51,510 --> 00:20:57,830 +system طبعا هذه برضه صورة كريكاترية بتبين ان كداش + +238 +00:20:57,830 --> 00:21:04,550 +احنا مدللينوليس متوفر الأعضاء وبراحة يعني هذا مريض + +239 +00:21:04,550 --> 00:21:08,270 +رايح على طبيب ليه لأني أنا vegetarian وبالتالي + +240 +00:21:08,270 --> 00:21:18,810 +يعني انا بدي ارشي كوك هارتز قلب من نوع خرشوف فاهم + +241 +00:21:18,810 --> 00:21:22,410 +شو اللي بيصير كده بيصير في ما هي ردود الفعل ما هي + +242 +00:21:22,410 --> 00:21:28,230 +الميكانيزمات التي تصاحب عملية ال rejectionسنبدأ + +243 +00:21:28,230 --> 00:21:33,010 +بالتعرف على الـ Immunity in Human Infants نحن نعرف + +244 +00:21:33,010 --> 00:21:39,150 +أنه تبروتين أنتجين ستموليشن تي سيل ديبندنت جامعي + +245 +00:21:39,150 --> 00:21:45,490 +كومبتانت انتباد رسبونس أو سيل ميديات رسبونس + +246 +00:21:45,490 --> 00:21:54,180 +البروتين بيكون فيه اميون رسبونس قوي لان همالبروتين + +247 +00:21:54,180 --> 00:21:59,720 +قوي البروتين و in case of T cell dependent يعني + +248 +00:21:59,720 --> 00:22:04,260 +انت معتمدين فيه على T lymphocytes ال T lymphocyte + +249 +00:22:04,260 --> 00:22:07,220 +تتنشط و اما بتنشط لنا ال B lymphocyte و بتكون + +250 +00:22:07,220 --> 00:22:11,100 +antibody او بتنشط ميكرفيجي و تعملنا cell related + +251 +00:22:11,100 --> 00:22:15,620 +immunity to carbohydrate antigen في حالات ال cell + +252 +00:22:15,620 --> 00:22:21,260 +T cell independent ال + +253 +00:22:21,260 --> 00:22:26,430 +antibodiesgenerally responses is generally + +254 +00:22:26,430 --> 00:22:30,930 +impaired طبعا + +255 +00:22:30,930 --> 00:22:39,570 +هذا بيبين انه في أول ست شهور من العمر ما بتكونوش + +256 +00:22:39,570 --> 00:22:47,810 +ال EBO انتجين وبالتالي it's safe في هذه المرحلة + +257 +00:22:47,810 --> 00:22:59,650 +انهلإستخدام حتى blood-incompatible ABO.Types + +258 +00:22:59,650 --> 00:23:02,370 +of Transplant Graft Rejection تفقنا على أنه فيه + +259 +00:23:02,370 --> 00:23:06,090 +Antibody mediated اللي هو Hyper Acute و Acute وفيه + +260 +00:23:06,090 --> 00:23:10,970 +Cellular وChronic نشوف ال rejection mechanism قلنا + +261 +00:23:10,970 --> 00:23:15,770 +في ال Acute و Hyper Acute في Antihlaalو Antibody + +262 +00:23:15,770 --> 00:23:20,800 +بيتكونبهاجم الـ endothelium of the testicular + +263 +00:23:20,800 --> 00:23:25,360 +capillary وفي النهاية الـ late capillary basement + +264 +00:23:25,360 --> 00:23:30,620 +membrane multilayering وglomerular deterioration + +265 +00:23:30,620 --> 00:23:35,170 +أول من يتأثر الكدنىT-cell-mediated rejection طبعا + +266 +00:23:35,170 --> 00:23:38,010 +بيحصل في الانفساط Infiltration وCytotoxic + +267 +00:23:38,010 --> 00:23:41,550 +destruction of a grafted parenchymal cell وطبعا + +268 +00:23:41,550 --> 00:23:46,010 +المهم في الموضوع دور Macrophage وDelayed type + +269 +00:23:46,010 --> 00:23:51,630 +hypersensitivity reaction وأكثر + +270 +00:23:51,630 --> 00:23:58,950 +ما target لهذه الخلاياهي مهاجماتها للاندوثيليام + +271 +00:23:58,950 --> 00:24:02,010 +والابيثيليام يعني انتما واسمه الارتريز في هذه + +272 +00:24:02,010 --> 00:24:07,450 +المناطق فبصير في انتما الارتريتس which is uncommon + +273 +00:24:07,450 --> 00:24:13,370 +لكن نيو انتما and disruption of elastic lamina + +274 +00:24:13,370 --> 00:24:19,870 +وinflammatory cell present during destruction وهي + +275 +00:24:19,870 --> 00:24:20,970 +اللي قاله graft rejection + +276 +00:24:27,510 --> 00:24:35,230 +T-lymphocyte تتعود بين أعضاء الأعضاء اللينفويدية و + +277 +00:24:35,230 --> 00:24:44,290 +أي صار في كدنيا response to injury لاحظوا انتجين + +278 +00:24:44,290 --> 00:24:48,790 +presenting cell moved to lymphoid organsوبتقدم + +279 +00:24:48,790 --> 00:24:54,530 +الانتجين لمين؟ لـ T-lymphocytes T البرسيل تساعد بي + +280 +00:24:54,530 --> 00:24:59,130 +سيل تعمل اللوانتيبودي طبعا في نفس الوجهة الـ T + +281 +00:24:59,130 --> 00:25:04,030 +-lymphocyte فكتور T cell home + +282 +00:25:04,400 --> 00:25:11,700 +to inflamed sites و CD4 بتنشط ال CD8 و بتبدأ ال + +283 +00:25:11,700 --> 00:25:16,820 +CD8 كمان تهاجم ال antibody وبالتالي both antibody + +284 +00:25:16,820 --> 00:25:20,760 +ال organ وبالتالي both antibody and cell mediated + +285 +00:25:20,760 --> 00:25:25,300 +immunity are playing a role في هذا الموضوع + +286 +00:25:29,360 --> 00:25:32,720 +بسيط موليكالية في تجارب الـ T-cell مدينة + +287 +00:25:32,720 --> 00:25:35,840 +الانفلترشين بيصير في تجارب الـ T-cell مدينة + +288 +00:25:35,840 --> 00:25:37,160 +الانفلترشين بيصير في تجارب الـ T-cell مدينة + +289 +00:25:37,160 --> 00:25:38,880 +الانفلترشين بيصير في تجارب الـ T-cell مدينة + +290 +00:25:38,880 --> 00:25:39,560 +الانفلترشين بيصير في تجارب الـ T-cell مدينة + +291 +00:25:39,560 --> 00:25:42,340 +الانفلترشين بيصير في تجارب الـ T-cell مدينة + +292 +00:25:42,340 --> 00:25:47,180 +الانفلترشين بيصير في تجارب الـ T-cell مدينة + +293 +00:25:47,180 --> 00:25:53,080 +الانفلترشين بيصير في تجارب الـ T-cell مدينة + +294 +00:25:53,080 --> 00:25:59,380 +الانفلترشين بيصير في تجارب الالانجري والرمير مالتو + +295 +00:25:59,380 --> 00:26:04,540 +مدرت سيفير فيبروسيز بارتو بوز بارنكايمل دي + +296 +00:26:04,540 --> 00:26:13,160 +ديفرانشيش بيسيل is infiltrated طبعا هاد ال + +297 +00:26:13,160 --> 00:26:19,650 +dendritic cell engage T cell كيف بتقدمT لـ + +298 +00:26:19,650 --> 00:26:23,590 +Dendritic Cell Antigen لـ T لـ Lymphocytes وطبعا + +299 +00:26:23,590 --> 00:26:26,710 +كما تشاهدون شرط أساسي ان يكون في cell to cell + +300 +00:26:26,710 --> 00:26:31,670 +contactكيف يقدم الانتجن الى الـ T lymphocyte؟ + +301 +00:26:31,670 --> 00:26:34,850 +قالوا بثلاث طرق مختلفة إما direct وإما indirect + +302 +00:26:34,850 --> 00:26:38,910 +وإما semi-direct في ال direct بيكون فيه donor + +303 +00:26:38,910 --> 00:26:42,810 +انتجن presenting cell يلي بتقدم الانتجن تعتبر هي + +304 +00:26:42,810 --> 00:26:46,710 +الانتجن presenting cell هي اللي بتقدم الانتجن ل T + +305 +00:26:46,710 --> 00:26:49,090 +lymphocyte of recipient + +306 +00:26:51,270 --> 00:26:55,130 +وفي الـ indirect ال host antigen presenting cell + +307 +00:26:55,130 --> 00:26:59,450 +تتعرف على ال donor antigen و بتاخده و بتعمله + +308 +00:26:59,450 --> 00:27:04,390 +processing و تقدمه لمين لل T lymphocytes و ال semi + +309 +00:27:04,390 --> 00:27:10,430 +direct host antigen presenting cellPresent intact + +310 +00:27:10,430 --> 00:27:15,590 +donor antigen يعني بنخلع الانتجن من ال donor cell + +311 +00:27:15,590 --> 00:27:18,350 +و بيجيبه جوعد على ال antigen presenting cell زي ما + +312 +00:27:18,350 --> 00:27:24,270 +هو بدون processing و بتقدم لل تيلينفوسات ال + +313 +00:27:24,270 --> 00:27:30,990 +indirect أي صار في shedding أخدته ال antigen + +314 +00:27:30,990 --> 00:27:36,800 +presenting cell و عملته processingوقدمته لـ T + +315 +00:27:36,800 --> 00:27:42,280 +مرتبط بالـ MSC موليكيول أيوة أخدته وعملته + +316 +00:27:42,280 --> 00:27:46,640 +processing وطلع مرتبط بال MSC موليكيول اللي بعد + +317 +00:27:46,640 --> 00:27:55,400 +هيك بتقدم ل CD4 T Cell طبعا نشطه بتطلع IL-2 و IL-2 + +318 +00:27:55,400 --> 00:28:03,080 +بتنشط CD8 وبالتالي بتقدم لها ال antigen أيضابعد ما + +319 +00:28:03,080 --> 00:28:08,020 +يتقدم إلى الـ Antigen الـ Class 1 MHC موليكيول الـ + +320 +00:28:08,020 --> 00:28:13,360 +Semi-direct زي ما هو بيصير فيه خلع لل Iochidin + +321 +00:28:13,360 --> 00:28:21,860 +للممبرين للـ Antigen ممبرين الـ Antigen ممبرين هي + +322 +00:28:21,860 --> 00:28:27,420 +شجرة من الـ Cell ممبرين تيجي و بتقعد زي ما هي على + +323 +00:28:27,420 --> 00:28:29,960 +سطح الـ Antigen Presenting Cell بتاعة الـ Host + +324 +00:28:30,530 --> 00:28:34,870 +ومباشرة بتقدمها ل CD8 لأنه في هذه الحالة هو عبارة + +325 +00:28:34,870 --> 00:28:40,790 +عن class one اللي برضه بيقدر يعمل مهاجمة مباشرة ل + +326 +00:28:40,790 --> 00:28:47,610 +الخلائع كانوا عشان تتنشط الخلية الـ T lymphocyte + +327 +00:28:47,610 --> 00:28:51,130 +بدها تلاتة signal وكلنا بنعرف أي أول signal ال + +328 +00:28:51,130 --> 00:28:54,630 +antigen presenting cell بتقدم ال antigen وبالتالي + +329 +00:28:54,630 --> 00:28:59,350 +بتقدمه ل T lymphocytes ماشي ثم ال co stimulation + +330 +00:29:01,080 --> 00:29:05,480 +فبصير فيه activation بصير فيه cytokine release + +331 +00:29:05,480 --> 00:29:10,560 +بتلعب دورة كبيرة على السلسل cell cycle cell cycle + +332 +00:29:10,560 --> 00:29:15,000 +cycling of the cell وبالتالي بصير فيه activation + +333 +00:29:15,000 --> 00:29:19,940 +دورة T لـ Cell lineage and cytokine انهاله graft + +334 +00:29:19,940 --> 00:29:25,320 +rejection جاله ال antigen غريب + +335 +00:29:28,840 --> 00:29:32,780 +الأول هو activation of T cell يعني بنشط لنا T لمو + +336 +00:29:32,780 --> 00:29:40,040 +فصاعد وفي هذه الحالة تتنشط both CD4 و CD8 وإذا + +337 +00:29:40,040 --> 00:29:43,740 +تنشطت بتفرزلنا ال cytokine معظم ال cytokine تطلع + +338 +00:29:43,740 --> 00:29:49,520 +من CD4 وأشهر أو أكتر cytokine تطلع من CD4 تتكوّن + +339 +00:29:49,520 --> 00:29:53,840 +في هذه الحالة هي IL-2 ثم ال interferon Alpha و + +340 +00:29:53,840 --> 00:29:57,540 +Beta و Gamma ثم tumor necrosis factor Alpha و Beta + +341 +00:29:59,140 --> 00:30:03,280 +طبعاً مشهدت طبعاً زي ما قلنا هذه الـ cytokine نشوف + +342 +00:30:03,280 --> 00:30:07,960 +إيش دور كل واحد منهم لأن الـ IL-2 مهم جداً كـ + +343 +00:30:07,960 --> 00:30:12,120 +proliferative و هي differentiation factor for + +344 +00:30:12,120 --> 00:30:16,960 +cytotoxic T لإنفسايته T لبر واحد و التالي بيصير + +345 +00:30:16,960 --> 00:30:23,420 +فيه delay type hypersensitivity reaction أثناء الـ + +346 +00:30:23,420 --> 00:30:27,000 +allograft rejection الجامعة الـ interferon مهم + +347 +00:30:27,000 --> 00:30:34,430 +جداًfor macrophage migration to the tissue damaged + +348 +00:30:34,430 --> 00:30:40,710 +تيومان كروس فاكتور بيتا هو برعنى cytotoxic اللي هو + +349 +00:30:40,710 --> 00:30:46,690 +agent for all cell اللي موجودة في الـ graft + +350 +00:30:46,690 --> 00:30:54,030 +ترفيرون ألفة وبيتا هو تيومان كروس فاكتور بيتا و + +351 +00:30:54,030 --> 00:30:58,150 +ألفة هدول بزاودوا ال expression of both plus one + +352 +00:30:58,700 --> 00:31:02,700 +موليكيول على كل الخلايا بينما الجامعة الـ + +353 +00:31:02,700 --> 00:31:06,620 +Interferon بتزود ال expression of class 2 موليكيول + +354 +00:31:06,620 --> 00:31:10,460 +وطبعا يوم يصير فيه زيادة في ال expression يعني في + +355 +00:31:10,460 --> 00:31:13,940 +زيادة في ال presentation في ال recognition + +356 +00:31:13,940 --> 00:31:21,600 +وبالتالي صار فيه effective immune response طبعا + +357 +00:31:21,600 --> 00:31:25,180 +ال chronic rejection جولنا poorly defined لكنه + +358 +00:31:25,180 --> 00:31:30,980 +بيصير بعد سنوات أشهر أو سنينوالعضو بيكون في اخلاق + +359 +00:31:30,980 --> 00:31:34,600 +الفترة هادى working و functioning very well لكن في + +360 +00:31:34,600 --> 00:31:39,480 +نهاية بيسلق اللي هو deterioration و infarction + +361 +00:31:39,480 --> 00:31:45,180 +وبالتالي بيخلص + +362 +00:31:45,180 --> 00:31:49,880 +ال طبعا + +363 +00:31:49,880 --> 00:31:56,050 +فعلا وع كثيرة kidney و heart و liverالذي يمكن أن + +364 +00:31:56,050 --> 00:32:00,410 +يكون مرتبط بـRecurrent Cellular Rejection + +365 +00:32:00,410 --> 00:32:06,670 +الانتيبادي ممكن تلعب دور وممكن ما تلعبش ليس مقاومة + +366 +00:32:06,670 --> 00:32:09,510 +حتى يتم استخدام مصطلح امينوسابرسيف + +367 +00:32:15,300 --> 00:32:18,720 +ميكانيزم انتجار ريكونيشن بي تيرينفرشايت انتجار + +368 +00:32:18,720 --> 00:32:22,240 +ريكونيشن بي تيرينفرشايت بتعتمد على ال micro + +369 +00:32:22,240 --> 00:32:25,220 +environment اللي بيحصل فيها ال immune response + +370 +00:32:27,770 --> 00:32:34,670 +الـ cytokine اللي بيفرز بيصير فيه response وخلّينا + +371 +00:32:34,670 --> 00:32:39,570 +نشوف هي ال response يعني في CD4، نييف CD4، في وجود + +372 +00:32:39,570 --> 00:32:46,390 +IL-12 تتنشط TELPAR-1 اللي بتفرز النجامة انترفيرون + +373 +00:32:46,390 --> 00:32:50,590 +و اللي بتنشط ميكروفيجيا يعني دلوقتي الـ + +374 +00:32:50,590 --> 00:32:54,990 +hypersensitivity reaction is induced وفي وجود IL + +375 +00:32:54,990 --> 00:32:56,170 +-4، TELPAR-2 + +376 +00:32:58,980 --> 00:33:03,320 +وهي تشغّل الـ IL-5 وهي تشغّل الـ neutrophilic + +377 +00:33:03,320 --> 00:33:07,520 +rejection وفي وجود الـ Transformed Growth Factor + +378 +00:33:07,520 --> 00:33:15,520 +Beta و IL-6 و IL-23 T البر سبنتين تشغّل ويعني IL + +379 +00:33:15,520 --> 00:33:20,780 +-17 تشغّل الـ neutrophilic rejection بينما في وجود + +380 +00:33:20,780 --> 00:33:24,180 +الـ Transformed Growth Factor Beta تشغّل تشغّل + +381 +00:33:26,310 --> 00:33:30,690 +بتعمل activation لكل الميكانيزمات وبالتالي بتعمل + +382 +00:33:30,690 --> 00:33:37,570 +promotion لل graph acceptance ماشي يبقى حسب ايش + +383 +00:33:37,570 --> 00:33:41,150 +حسب اللي هو الميكانيزم طبعا زي ما انتوا شايفين + +384 +00:33:41,150 --> 00:33:44,730 +تيرنج بتعمل inactivation لتير بار واحد تير بار + +385 +00:33:44,730 --> 00:33:47,930 +اتنين وكمان تير بار واحد تير بار اتنين كل واحدة + +386 +00:33:47,930 --> 00:33:52,950 +منهم بتعمل inactivation للتانية وفي نفس الوقت + +387 +00:33:52,950 --> 00:33:55,430 +بيعملوا inactivation لتير بار سبنتين + +388 +00:33:58,350 --> 00:34:01,470 +الدراجين الاساسيه في انها نوع كثيرة منها الجلوكو + +389 +00:34:01,470 --> 00:34:07,870 +كورتيكوستيرويد وفي نوع تانى اسمه موليكيول دراج زي + +390 +00:34:07,870 --> 00:34:13,270 +الازفثيوبرين والكالسين يورين انهيبيتور زي الـ + +391 +00:34:13,270 --> 00:34:17,230 +Cyclosporine يعني مش ساحه اخد في هذه المواد كثيرة + +392 +00:34:17,230 --> 00:34:23,950 +في Depleting Antibody يعني Anti-CD3 وAnti-CD25 + +393 +00:34:23,950 --> 00:34:28,190 +تعمل انهيبيشن لactivation of T cellفيه non + +394 +00:34:28,190 --> 00:34:34,510 +-deblating وها كذا هي الأنواع المختلفة من أيش هي + +395 +00:34:34,510 --> 00:34:41,230 +التكريلة لمص وت ساكلوسبورين بيشتغلوها CTLA4 مشتغل + +396 +00:34:41,230 --> 00:34:45,890 +على ال co-stimulation Anti-CD25 بيعمل ان هي مش + +397 +00:34:45,890 --> 00:34:51,470 +انها cell cycling لإنه من الأول بيوقف ال cytokine + +398 +00:34:51,470 --> 00:34:52,450 +release وها كذا + +399 +00:34:55,500 --> 00:35:00,460 +الـ graft vs host disease جال من الاسم graft vs + +400 +00:35:00,460 --> 00:35:04,160 +host disease لما الإنسان يكون immunocompromised + +401 +00:35:04,160 --> 00:35:09,820 +وينتقلوا immunocompetent tissue or organs هذا ال + +402 +00:35:09,820 --> 00:35:13,960 +tissue و ال organs هيبدأ يهاجم اللي هو أنتيجنات ال + +403 +00:35:13,960 --> 00:35:17,760 +host وبيعمل حاجة بيسموها graft vs host disease + +404 +00:35:17,760 --> 00:35:21,640 +وطبعا وقت إيش بيصير الإنسان immunocompromised + +405 +00:35:21,640 --> 00:35:31,020 +يتعرض لهاRadiation اتعرض لكيموترابي whatever فبصير + +406 +00:35:31,020 --> 00:35:36,360 +في عنده المناعة بعيفة وبالتالي سؤال جدا انه يهاجم + +407 +00:35:36,360 --> 00:35:46,160 +by the donor immune cells بصير هذا الكلام في حالات + +408 +00:35:46,160 --> 00:35:52,220 +ال bone marrowو في هذه الحالة طبعا اكتر الحاجات + +409 +00:35:52,220 --> 00:35:56,860 +اللي هتستخدمه اوتولوجيا سبون مارو و أبالكال كورد + +410 +00:35:56,860 --> 00:36:01,740 +ال blood و طبعا هي هذه صورة الرعاش و ال hemorrhage + +411 +00:36:01,740 --> 00:36:05,200 +و ال bleeding under the skin من ال graft versus + +412 +00:36:05,200 --> 00:36:09,740 +disease بالمناسبة هذا ممكن يد إلى الوفاة if + +413 +00:36:09,740 --> 00:36:10,540 +untreated + +414 +00:36:12,870 --> 00:36:16,750 +طيب احنا الموضوع الأخير اللي بدنا نحكي فيه هو why + +415 +00:36:16,750 --> 00:36:20,830 +fetus is not rejected by the mother لأنه مع العلم + +416 +00:36:20,830 --> 00:36:24,430 +انه بيحمل أنتجينات من ال parent من ال father + +417 +00:36:24,430 --> 00:36:29,190 +وبالتالي أنتجيناته غريبة الا انه it's not rejected + +418 +00:36:29,190 --> 00:36:34,930 +و هذه هي ال strain A و ال strain B المفروض انه يوم + +419 +00:36:34,930 --> 00:36:40,450 +يدخل أنتجين غريب يصير فيه graft rejectionلنشوف ليش + +420 +00:36:40,450 --> 00:36:44,350 +بيصير فيه tolerated allograft في ال fetus طبعا + +421 +00:36:44,350 --> 00:36:51,410 +يعني في عدة أسباب بتمنععملية الـ immune response و + +422 +00:36:51,410 --> 00:36:57,450 +rejection of fetus منها أن الـ antibodies which + +423 +00:36:57,450 --> 00:37:00,830 +are formed are harmless to the fetus ليس كلها + +424 +00:37:00,830 --> 00:37:06,010 +مجتمع بسبب البلسينتا نمرا اتنين ال mother does not + +425 +00:37:06,010 --> 00:37:09,730 +produce cytotoxic telephosphate against the fetus + +426 +00:37:09,730 --> 00:37:15,830 +نمرا تلاتة ال fetal trophoblast جاله و هذا طبعا + +427 +00:37:15,830 --> 00:37:18,110 +بيشكل ال outer layer of the placenta + +428 +00:37:20,610 --> 00:37:26,410 +هذه المنطقة لا تدعى MHC class 1 ولا 2 لكنها تدعى + +429 +00:37:26,410 --> 00:37:32,630 +نوع تاني من ال HLA وهو 1B MHC موليكيول وهم يسموها + +430 +00:37:32,630 --> 00:37:40,210 +HLAG ووجدوا ان الـ fetal trophoblast لا تتعامل مع + +431 +00:37:40,210 --> 00:37:44,410 +الـ cellular immune response لأنه مافي عليها MHC + +432 +00:37:44,410 --> 00:37:49,740 +class 1 ولا 2ماذا يفعل الـ HLAG؟ هو عبارة عن لجند + +433 +00:37:49,740 --> 00:37:54,340 +للـ KIR ونعرف أن الـ KIR هو عبارة عن الـHepatory + +434 +00:37:54,340 --> 00:37:58,440 +Receptor موجود على سطح الـ Ankyl Cell وبالتالي يوم + +435 +00:37:58,440 --> 00:38:03,460 +تعمله Blocking بالـ HLAG، مافيش شغل للـ Ankyl Cell + +436 +00:38:03,460 --> 00:38:09,140 +أيضًا الـ HLAG وجدوا موجود في الـ Thymic Medullary + +437 +00:38:09,140 --> 00:38:13,820 +Epithelium وهدب يعني إنه في تيسل توليرانس to this + +438 +00:38:13,820 --> 00:38:23,680 +moleculeنقطة أخرى قالوا لا يوجد في الملسينتا هذه + +439 +00:38:23,680 --> 00:38:26,660 +الخلائع لا يوجد في الملسينتا هذه الخلائع لا يوجد + +440 +00:38:26,660 --> 00:38:30,160 +في الملسينتا هذه الخلائع لا يوجد في الملسينتا هذه + +441 +00:38:30,160 --> 00:38:33,260 +الخلائع لا يوجد في الملسينتا هذه الخلائع لا يوجد + +442 +00:38:33,260 --> 00:38:33,320 +في الملسينتا هذه الخلائع لا يوجد في الملسينتا هذه + +443 +00:38:33,320 --> 00:38:33,980 +الخلائع لا يوجد في الملسينتا هذه الخلائع لا يوجد + +444 +00:38:33,980 --> 00:38:35,500 +الخلائع لا يوجد في الملسينتا هذه الخلائع لا يوجد + +445 +00:38:35,500 --> 00:38:40,900 +في الملسينتا هذه الخلائع لا يوجد في الملسينتا هذه + +446 +00:38:40,900 --> 00:38:45,870 +الخلائع لا يوجد في الملسبرضه هذا مباشرة كـ + +447 +00:38:45,870 --> 00:38:49,170 +Immunosuppressive Properties مانعته بمنع ال + +448 +00:38:49,170 --> 00:38:54,970 +rejection وبالتالي بيعتبر الفيتس موجود في أماكن + +449 +00:38:54,970 --> 00:38:59,370 +محمية من البقية اللي اللي اللي ال immune response + +450 +00:38:59,370 --> 00:39:04,010 +بيسمو هذا المكان immunologically privileged site + +451 +00:39:04,010 --> 00:39:07,130 +أماكن محمية مناعيا + +452 +00:39:09,150 --> 00:39:14,190 +طبعا هذه الكاركاتيريا بتبين ان انواع الأخلاقية + +453 +00:39:14,190 --> 00:39:19,430 +لعملية اللي هو transplantation ان الإنسان مش لازم + +454 +00:39:19,430 --> 00:39:28,010 +يبيع أعضاء علشان لأي سبب من الأسباب organ for sale + +455 +00:39:28,010 --> 00:39:33,190 +طبعا هذا مش مظبوط وانتوا عارفين لو كل إنسان لو + +456 +00:39:33,190 --> 00:39:37,750 +كلنا متشابهين كان كلنا جتلنا بعض عشان نعيش ناخد + +457 +00:39:37,750 --> 00:39:43,960 +أعضاء بعضعند الحاجة اللي هم و بالتالي ال summary + +458 +00:39:43,960 --> 00:39:52,100 +طبعا هو هذا ال end of lecture و شكرا جزيلا + +459 +00:39:52,100 --> 00:39:52,880 +للاستماع + diff --git a/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/jdGOJ1cxTIc_raw.json b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/jdGOJ1cxTIc_raw.json new file mode 100644 index 0000000000000000000000000000000000000000..faa0f880254d9e5bcfc31d9860ca5b8b0d8d79d6 --- /dev/null +++ b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/jdGOJ1cxTIc_raw.json @@ -0,0 +1 @@ +{"segments": [{"id": 1, "seek": 2229, "start": 1.79, "end": 22.29, "text": "بسم الله الرحمن الرحيم اليوم ان شاء الله هنحكي في محاضرة جديدة بعنوان Transplantation Immunology هنتعرف فيها على definitions Transplantation Antigen Antigen Presentation Recognition Mechanism of Rejection", "tokens": [3555, 38251, 21984, 34892, 5016, 27842, 34892, 5016, 32640, 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"temperature": 1.0}, {"id": 84, "seek": 219803, "start": 2172.87, "end": 2198.03, "text": "طيب احنا الموضوع الأخير اللي بدنا نحكي فيه هو why fetus is not rejected by the mother لأنه مع العلم انه بيحمل أنتجينات من ال parent من ال father وبالتالي أنتجيناته غريبة الا انه it's not rejected و هذه هي ال strain A و ال strain B المفروض انه يوم يدخل أنتجين غريب يصير فيه graft rejection", "tokens": [9566, 1829, 3555, 1975, 5016, 8315, 9673, 2407, 11242, 45367, 16247, 9778, 13546, 13672, 1829, 47525, 8315, 8717, 5016, 4117, 1829, 8978, 3224, 31439, 983, 15136, 301, 307, 406, 15749, 538, 264, 2895, 5296, 33456, 3224, 20449, 18863, 19528, 16472, 3224, 4724, 1829, 35571, 1211, 14739, 2655, 7435, 1829, 8315, 2655, 9154, 2423, 2596, 9154, 2423, 3086, 46599, 6027, 2655, 6027, 1829, 14739, 2655, 7435, 1829, 8315, 47395, 32771, 16572, 49401, 42963, 16472, 3224, 309, 311, 406, 15749, 4032, 29538, 39896, 2423, 14249, 316, 4032, 2423, 14249, 363, 9673, 5172, 32887, 11242, 16472, 3224, 7251, 20498, 7251, 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{"id": 85, "seek": 220711, "start": 2199.13, "end": 2207.11, "text": "لنشوف ليش بيصير فيه tolerated allograft في ال fetus طبعا يعني في عدة أسباب بتمنع", "tokens": [1211, 1863, 8592, 38688, 32239, 8592, 4724, 1829, 9381, 13546, 8978, 3224, 11125, 770, 439, 664, 4469, 8978, 2423, 15136, 301, 23032, 3555, 3615, 995, 37495, 22653, 8978, 6225, 41891, 5551, 35457, 16758, 39894, 27842, 3615], "avg_logprob": -0.44383446268133214, "compression_ratio": 1.0982142857142858, "no_speech_prob": 0.0, "words": [{"start": 2199.13, "end": 2199.97, "word": "لنشوف", "probability": 0.66021728515625}, {"start": 2199.97, "end": 2200.45, "word": " ليش", "probability": 0.782958984375}, {"start": 2200.45, "end": 2200.85, "word": " بيصير", "probability": 0.764404296875}, {"start": 2200.85, "end": 2201.17, "word": " فيه", "probability": 0.473388671875}, {"start": 2201.17, "end": 2202.09, "word": " tolerated", "probability": 0.675048828125}, {"start": 2202.09, "end": 2202.77, "word": " allograft", "probability": 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+00:00:05,180 --> 00:00:14,440 +الـ cytokine و cytokine تعريفا هي ببساطة مجموعة من + +3 +00:00:14,440 --> 00:00:21,280 +الـ chemical messenger وظائفها + +4 +00:00:21,280 --> 00:00:25,860 +نمرة واحد مدية and regulate the immune system و + +5 +00:00:25,860 --> 00:00:30,000 +بتعمل regulation للـ immune system. من صفاتها أن + +6 +00:00:30,000 --> 00:00:33,880 +their secretion is brief and self-limited لحالة + +7 +00:00:33,880 --> 00:00:40,540 +نمرة تلاتة individual cytokine can be produced by + +8 +00:00:40,540 --> 00:00:44,800 +multiple cell type يعني أكثر من خلية كان ممكن + +9 +00:00:44,800 --> 00:00:51,650 +تعطينا هذه الـ cytokine. كمان من صفاته أنه act on + +10 +00:00:51,650 --> 00:00:56,450 +multiple cell types يعني pleiotropic الـ + +11 +00:00:56,450 --> 00:01:03,090 +pleiotropism أن one cytokine ممكن يشتغل على أكثر + +12 +00:01:03,090 --> 00:01:09,690 +من خلية. وهذا مثال حي على ذلك هي activated T-helper + +13 +00:01:09,690 --> 00:01:16,110 +cell. شايفين الـ pleiotropy طلع لنا آية 4 اللي ممكن + +14 +00:01:16,930 --> 00:01:23,670 +يشتغل على lymphocytes، على thymocytes، وعلى muscle + +15 +00:01:23,670 --> 00:01:31,870 +وطبعا نعرف احنا أنه its action أو الـ end result of + +16 +00:01:31,870 --> 00:01:35,310 +its action اللي هو proliferation and + +17 +00:01:35,310 --> 00:01:39,630 +differentiation for these cells. يبقى زي ما أنتو + +18 +00:01:39,630 --> 00:01:43,980 +شايفين one cytokine can act on different cells. They + +19 +00:01:43,980 --> 00:01:48,980 +are also redundant بمعنى أن multiple cytokines can + +20 +00:01:48,980 --> 00:01:57,040 +act on one cell. ماشي. and multiple cytokines يعني + +21 +00:01:57,040 --> 00:02:00,880 +different cytokines may have the same effect on + +22 +00:02:00,880 --> 00:02:06,300 +target cell واحدة. بيسموهم redundant اللي هو + +23 +00:02:06,300 --> 00:02:11,400 +التكرار. وطبعا زي ما أنت شايفين IL-2، 4، 5 بيشتغلوا على + +24 +00:02:11,400 --> 00:02:16,040 +B-lymphocyte طالعين من B من T cell. T cell عملوا + +25 +00:02:16,040 --> 00:02:22,660 +proliferation for B-lymphocytes. أيضا من صفاتهم أن + +26 +00:02:22,660 --> 00:02:28,960 +they can affect the synthesis of each other. واحد + +27 +00:02:28,960 --> 00:02:35,800 +ممكن يأثر على تكوين الثاني أو إنتاج الثاني. أيضا الـ + +28 +00:02:35,800 --> 00:02:41,040 +synergism، الـ synergistic اللي هو اثنين أو أكثر + +29 +00:02:41,040 --> 00:02:49,420 +cytokine may have greater than additive effect. + +30 +00:02:49,420 --> 00:03:00,380 +اثنين بيساعدوا وبيعملوا تأثير إضافي على الخلية أو + +31 +00:03:00,380 --> 00:03:04,380 +Antagonism بمعنى أن واحد ممكن يشتغل ضد الثاني، واحد + +32 +00:03:04,380 --> 00:03:08,660 +ممكن يشتغل ضد الثاني. وهذه أمثلة على ذلك على الـ + +33 +00:03:08,660 --> 00:03:13,200 +scenario هي IL-4 و IL-5 يشتغلوا على B lymphocytes و + +34 +00:03:13,200 --> 00:03:19,940 +قدّوا إلها إنتاج الـ IGE عملوا class switching بينما + +35 +00:03:19,940 --> 00:03:24,080 +في antagonism زي ما أنتو شايفين الـ IL-4 منتج + +36 +00:03:24,080 --> 00:03:30,060 +من الـ activity الـ T cell عشان ينشطلي مين اللي هو + +37 +00:03:30,060 --> 00:03:34,320 +B lymphocyte. فأجى الجامعة interferon وعمل blocking للـ + +38 +00:03:34,320 --> 00:03:39,860 +IL-4 وبالتالي منع اللي هو الـ class switching of + +39 +00:03:39,860 --> 00:03:43,060 +IGE اللي بده ينتج. + +40 +00:03:45,950 --> 00:03:51,910 +أيضا الـ cytokine can act in a cascade يعني الـ + +41 +00:03:51,910 --> 00:03:59,550 +additive effect أو محصلة اللي هو عمل الـ cytokine + +42 +00:03:59,550 --> 00:04:08,070 +ممكن نشوفها على شكل cascade وبيسموا هذا التفاعل + +43 +00:04:08,070 --> 00:04:11,910 +cascade action. + +44 +00:04:13,120 --> 00:04:17,120 +فهي على سبيل المثال أو cascade induction هي على + +45 +00:04:17,120 --> 00:04:20,220 +سبيل المثال activated T-helper cell طلعت لنا gamma + +46 +00:04:20,220 --> 00:04:24,580 +interferon نشرت macrophage طلعت الـ macrophage IL + +47 +00:04:24,580 --> 00:04:30,440 +-12 اللي أيضا اشتغل على T-helper cell اكتفيته وأدتني + +48 +00:04:30,440 --> 00:04:34,420 +gamma interferon human necrosis factor IL-2 and + +49 +00:04:34,420 --> 00:04:38,980 +other cytokines. الـ action can be induced in a + +50 +00:04:38,980 --> 00:04:44,770 +cascade manner. الـ cytokine أيضًا من صفاتها إنه + +51 +00:04:44,770 --> 00:04:50,190 +they can act as a hormone فممكن يشتغلوا كـ in + +52 +00:04:50,190 --> 00:04:54,770 +autocrine action or paracrine action or endocrine + +53 +00:04:54,770 --> 00:04:58,750 +action. الـ autocrine إنه الخلية ممكن تشتغل على + +54 +00:04:58,750 --> 00:05:04,470 +نفسها. الـ paracrine على nearby cell. الـ endocrine on + +55 +00:05:04,470 --> 00:05:08,570 +a distant cell بمعنى blood circulation لغاية نفس + +56 +00:05:08,570 --> 00:05:16,770 +الخلية المطلوبة وهناك يؤثر عليها الخلية + +57 +00:05:16,770 --> 00:05:20,800 +التي تفرز هذه الـ cytokine and their function. قالوا + +58 +00:05:20,800 --> 00:05:24,280 +في مجموعة كبيرة من الخلايا capable of making + +59 +00:05:24,280 --> 00:05:28,360 +cytokine لكن أشهر هذه الخلايا هي macrophage + +60 +00:05:28,360 --> 00:05:35,200 +وT-helper cell. الـ their action involved in many + +61 +00:05:35,200 --> 00:05:39,500 +area منها الـ hematopoiesis، الـ adaptive immunity، الـ + +62 +00:05:39,500 --> 00:05:43,940 +innate immunity، الـ inflammation. وطبعا their activity + +63 +00:05:43,940 --> 00:05:49,610 +can be established in vitro by recombinant cytokine + +64 +00:05:49,610 --> 00:05:56,410 +which can be used as a therapeutic agent in vivo. + +65 +00:05:56,410 --> 00:06:03,230 +طيب صفات عامة للـ cytokine قالوا زي ما اتفقنا + +66 +00:06:03,230 --> 00:06:09,030 +ممكن يشتغل على innate immunity، بعضهم وطبعا في هذا + +67 +00:06:09,030 --> 00:06:11,790 +الحالة بيشتغلوا على الـ mononuclear phagocyte في + +68 +00:06:11,790 --> 00:06:15,750 +الـ innate immunity. أهم شيء الـ phagocytic cell in + +69 +00:06:15,750 --> 00:06:19,830 +response to infection. فبيشتغلوا كيف؟ بيشتغلوا على + +70 +00:06:19,830 --> 00:06:23,710 +الـ endothelial cell which lines blood vessels. + +71 +00:06:23,710 --> 00:06:27,630 +وبالتالي بيعملوا لها activation فبيصير فيه + +72 +00:06:27,630 --> 00:06:32,410 +retraction لهذه الخلايا وبالتالي مما يسمح بانزلاق + +73 +00:06:32,410 --> 00:06:37,190 +الـ neutrophil من داخل الـ blood vessels إلى خارجها. + +74 +00:06:37,190 --> 00:06:41,730 +بنجد إن they can act in leukocyte activation. + +75 +00:06:41,730 --> 00:06:50,590 +طبعا هذه حاجة مثال على ده، الكتابة macrophage factor + +76 +00:06:52,050 --> 00:06:54,570 +which can cause endothelial cell to produce a + +77 +00:06:54,570 --> 00:07:00,390 +digestive molecule طبعا لمين؟ للـ lymphocyte and secret + +78 +00:07:00,390 --> 00:07:18,010 +chemokine طالعة من هنا مثل + +79 +00:07:18,010 --> 00:07:20,410 +آخر الـ seven زي الـ human + +80 +00:07:24,080 --> 00:07:29,580 +gamma interferon. وهذا معروف أنه بيعمل activation + +81 +00:07:29,580 --> 00:07:35,640 +للميكروفاج. معتني أو من وظائفهم الأخرى أنه كان + +82 +00:07:35,640 --> 00:07:41,840 +ساعد، كان بـ mediate the action of adaptive + +83 +00:07:41,840 --> 00:07:47,440 +immune system and regulate في نفس الوجود. طبعا ده + +84 +00:07:47,440 --> 00:07:50,920 +مطلع غالبا الـ cytokine من الـ T lymphocyte وT + +85 +00:07:50,920 --> 00:07:54,540 +lymphocyte احنا عارفين T cell اللي هي الـ + +86 +00:07:54,540 --> 00:07:58,620 +orchestrate cell في الـ adaptive immune cell اللي + +87 +00:07:58,620 --> 00:08:04,780 +هي من توزع المهام على خلايا كثيرة. طبعا الـ + +88 +00:08:04,780 --> 00:08:07,680 +lymphocyte can also induce growth and + +89 +00:08:07,680 --> 00:08:14,510 +differentiation during their activation وبيطلع لنا + +90 +00:08:14,510 --> 00:08:17,010 +في النهاية effector cell و memory cell من الـ + +91 +00:08:17,010 --> 00:08:19,930 +effector cell اللي ممكن تتنشر اللي هي الـ + +92 +00:08:19,930 --> 00:08:24,970 +phagocytic cell زي الـ neutrophil و eosinophil و الـ + +93 +00:08:24,970 --> 00:08:33,370 +other adaptive immune cells. قسموها إلى activator + +94 +00:08:33,370 --> 00:08:38,990 +of cytotoxic response بمعنى adaptive طبعا بمعنى أنه + +95 +00:08:38,990 --> 00:08:47,450 +تنشيط الـ cytotoxic cell، T cell والـ NK cell. أهم + +96 +00:08:47,450 --> 00:08:52,170 +الـ cytokine بتطلع من هذه المجموعة هي IL-2، IL-3. + +97 +00:08:52,170 --> 00:08:58,350 +طبعا كلنا بنعرف الـ IL-2 هو عبارة عن T cell و الـ + +98 +00:08:58,350 --> 00:09:02,790 +cytokine بتطلع منها وبنشطها في نفس الوقت. IL-3 هو + +99 +00:09:02,790 --> 00:09:05,610 +عبارة عن father of cytokine بيشتغل أكثر من خلية من + +100 +00:09:05,610 --> 00:09:11,670 +ضمنهم هذه الخلايا. جامعة interferon زي و زي هي + +101 +00:09:11,670 --> 00:09:12,250 +قالوا + +102 +00:09:14,730 --> 00:09:18,010 +lymphotoxin زي و زي الـ human necrosis factors زي + +103 +00:09:18,010 --> 00:09:22,130 +ما طوي شوفنا. can induce fever و can mediate + +104 +00:09:22,130 --> 00:09:27,150 +chemotaxis أو كـ chemotactic في الهيجانس وبالتالي في + +105 +00:09:27,150 --> 00:09:31,170 +علاقة مباشرة ما بين الـ adaptive و الـ innate immune + +106 +00:09:31,170 --> 00:09:37,190 +response. هي activator للـ humoral response. + +107 +00:09:37,190 --> 00:09:41,770 +induction of B cell activation. احنا عارفين B cell + +108 +00:09:42,050 --> 00:09:46,990 +هي الـ humoral response وبعدها تبين immunity + +109 +00:09:46,990 --> 00:09:54,230 +طلعنا antibody humoral part. من أشهر هذه الـ + +110 +00:09:54,230 --> 00:10:01,910 +cytokine في هذه المجموعة IL-2 واللي بيطلع من الـ T + +111 +00:10:01,910 --> 00:10:07,030 +cell و بيعمل بيأثر على الـ B lymphocyte آية التلاتة. + +112 +00:10:07,030 --> 00:10:11,590 +قولنا father، آية الأربعة زي و زي اثنين في وجود + +113 +00:10:11,590 --> 00:10:20,110 +خمسة بيدينا IgA والخمسه لحاله IgA. سته ممكن يعمل B + +114 +00:10:20,110 --> 00:10:23,350 +cell differentiation to plasma cell transforming + +115 +00:10:23,350 --> 00:10:26,670 +growth factor beta. هذا عبارة عن inhibitory + +116 +00:10:26,670 --> 00:10:31,640 +cytokine. gamma interferon هو بقى بيعمل switching to + +117 +00:10:31,640 --> 00:10:38,980 +IgG instead of IgM. المجموعة التالتة هي activator + +118 +00:10:38,980 --> 00:10:43,320 +of inflammation or inflammatory cells. وطبعا هذا + +119 +00:10:43,320 --> 00:10:47,700 +type 2 interferon أو الـ gamma interferon هو برهان + +120 +00:10:47,700 --> 00:10:51,620 +inflammatory cytokine can be released during + +121 +00:10:51,620 --> 00:10:59,100 +activation of phagocytic cell. مو أخر من الـ function + +122 +00:10:59,100 --> 00:11:03,900 +للـ cytokine هي simulator of hemopoiesis. وطبعا + +123 +00:11:03,900 --> 00:11:08,180 +كلنا بنعرف hemopoiesis يعني تنشيط إنتاج خلايا الدم + +124 +00:11:08,180 --> 00:11:13,060 +واحنا عارفين أن كل خلية من خلايا الدم عشان تنتقل + +125 +00:11:13,060 --> 00:11:18,820 +من الـ immature للـ mature بتحتاج الـ cytokine عشان + +126 +00:11:18,820 --> 00:11:22,640 +تنوجد من الأساس بتحتاج الـ growth factor وفي أنواع + +127 +00:11:22,640 --> 00:11:26,200 +كثيرة من هذه الـ cytokine زي IL-3 أو 7 أو colony + +128 +00:11:26,200 --> 00:11:32,320 +stimulating factor و GM-CSF و M-CSF و G-CSF كلها + +129 +00:11:32,320 --> 00:11:37,680 +عبارة عن colony stimulating factor. الـ cytokine + +130 +00:11:40,090 --> 00:11:45,330 +أيضا زي ما اتفقنا أنه بيشتغل كان ممكن يملأ كلها + +131 +00:11:45,330 --> 00:11:48,810 +الوظائف اللي احنا حكينا عليها توّ. فمنها على سبيل + +132 +00:11:48,810 --> 00:11:54,330 +مثال هي activated macrophage في حالة تنشيط macrophage + +133 +00:11:54,330 --> 00:11:58,600 +يطلع cytokine تعمل نشطة hemopoiesis. بتطلع + +134 +00:11:58,600 --> 00:12:03,000 +cytokine can activate T-helper cell. بتنشط، بتطلع + +135 +00:12:03,000 --> 00:12:06,880 +cytokine يوم ما ترتبط فيها أو تقدم الـ antigen للـ T + +136 +00:12:06,880 --> 00:12:10,700 +-helper cell، resting T-helper cell، ممكن تتنشطها. + +137 +00:12:10,700 --> 00:12:14,420 +طبعا يوم ما تتنشط الـ resting T-helper cell وتتحول + +138 +00:12:14,420 --> 00:12:18,590 +ل activated بتنشط الـ macrophage مرة ثانية. الـ + +139 +00:12:18,590 --> 00:12:21,230 +macrophage يوم ما تتنشط كمان الـ adaptive immune + +140 +00:12:21,230 --> 00:12:27,770 +system يمكن أن يكون activated وكلهم يمكن أن يؤدوا + +141 +00:12:27,770 --> 00:12:32,590 +إلى Inflammatory Reaction أي يوم ما تتنشط وتتعدى + +142 +00:12:32,590 --> 00:12:36,710 +وبالتالي الـ Cytokine يمكن أن يسيطر على عملية + +143 +00:12:36,710 --> 00:12:39,030 +عملية عملية عملية عملية عملية عملية عملية عملية + +144 +00:12:39,030 --> 00:12:45,910 +عملية عملية عملية عملية عملية عملية + +145 +00:12:45,910 --> 00:12:49,150 +عملية عملية عملية عملية عملية عملية كل واحد + +146 +00:12:49,150 --> 00:12:53,450 +من وين بيطلع وإيش وظيفته طبعا مش مطالبين بالحفظ + +147 +00:12:53,450 --> 00:12:58,630 +بس ضروري تعرفوا الـ Measure Type هذه صورة الـ + +148 +00:12:58,630 --> 00:13:02,670 +Hemopoietic Tree وزي ما اتفقنا كل خطوة من الخطوات + +149 +00:13:02,670 --> 00:13:07,350 +تحتاج إلى سايتوكاين عشان يدخل الخلية من مرحلة إلى + +150 +00:13:07,350 --> 00:13:14,000 +أخرى الـ Cytokines Are Non-Specific واحنا طبعا طول + +151 +00:13:14,000 --> 00:13:17,640 +شوفنا إن هم They Are Non-Specific أكثر من Cytokine + +152 +00:13:17,640 --> 00:13:21,220 +بيشتغل على خلية الـ Cytokine بيشتغل على واحد بيشتغل + +153 +00:13:21,220 --> 00:13:26,420 +على أكثر من خلية طبعا كيف إن الـ Cytokines Are Non + +154 +00:13:26,420 --> 00:13:29,940 +Specific وفي نفس الوقت الـ Immune System Is + +155 +00:13:29,940 --> 00:13:32,720 +Specific ماشي + +156 +00:13:34,080 --> 00:13:37,800 +How Does Immune Specificity Fit With Non-Specific + +157 +00:13:37,800 --> 00:13:40,960 +Cytokine؟ كيف ممكن تفسير هذه الظاهرة؟ جا له ال + +158 +00:13:40,960 --> 00:13:47,160 +Answer نمرة واحد Through Receptor الـ Receptor اللي + +159 +00:13:47,160 --> 00:13:52,520 +موجودة على الـ Antigen Activated Cell هي فقط ترتبط + +160 +00:13:52,520 --> 00:13:57,230 +بـ Certain Cytokine نمرة اثنين Close Proximity + +161 +00:13:57,230 --> 00:14:03,290 +بمعنى إن الخلايا اللي جنب وجودها بجوار بعض بتدي + +162 +00:14:03,290 --> 00:14:11,250 +إلى اللي هو تفاعل أو وجود الـ Cytokine أو وصول الـ + +163 +00:14:11,250 --> 00:14:16,880 +Cytokine من شغلها إلى الأخرى.أحسن مثال على ذلك وجود + +164 +00:14:16,880 --> 00:14:20,440 +الـ Antigen Presenting Cell كيف يتقدم الـ Antigen التي هي + +165 +00:14:20,440 --> 00:14:23,380 +الـ بريسيل وبالتالي بيصير فيه ارتباط ما بين هذه و + +166 +00:14:23,380 --> 00:14:30,480 +هذه .. Both Cells و .. و متى ما صار ارتباط بيصير + +167 +00:14:30,480 --> 00:14:38,900 +في Cytokine Release Concentration Of Cytokine Are + +168 +00:14:38,900 --> 00:14:40,140 +Locally High + +169 +00:14:45,040 --> 00:14:48,460 +ولوكاليا ويوم ما يحصل في ارتباط فقط الـ Antigen + +170 +00:14:48,460 --> 00:14:54,460 +Presenting Cell هي اللي بتتنشط الإجابة + +171 +00:14:54,460 --> 00:14:57,680 +الثالثة على هذا السؤال إن They Have Short Half + +172 +00:14:57,680 --> 00:15:03,240 +Life و Short Half Life Ensure That Local Activity + +173 +00:15:03,240 --> 00:15:10,060 +Of The Cytokine هي مثال على ذلك هي عبارة عن خلية + +174 +00:15:10,060 --> 00:15:16,200 +صارت نشطت صار في Stimulus Inducing Stimulus طلعت + +175 +00:15:16,200 --> 00:15:20,740 +لما اتنشطت طلعت لنا Cytokine والـ Cytokine يجي + +176 +00:15:20,740 --> 00:15:26,340 +على الـ Nearby Cell وارتبط بالـ Specific Receptor + +177 +00:15:26,340 --> 00:15:29,780 +اللي هو For This Cytokine طبعا متى ما صار في + +178 +00:15:29,780 --> 00:15:34,660 +ارتباط بيصير في Biological Effectالـ سايتوكاين + +179 +00:15:34,660 --> 00:15:38,940 +ريسبتور لأ لو فيه خمس Major Family للـ سايتوكاين + +180 +00:15:38,940 --> 00:15:43,240 +ريسبتور نمرة واحد Immunoglobulin Superfamily نمرة + +181 +00:15:43,240 --> 00:15:48,040 +اثنين Hemopoietin Receptor بيسموهم Class One Type + +182 +00:15:48,040 --> 00:15:54,140 +ثم Interferon Receptor أو بيسموهم Class Two Type + +183 +00:15:54,140 --> 00:16:00,720 +يعني و ثم Human Cross Factor Receptor Family ثم + +184 +00:16:00,720 --> 00:16:07,420 +Chemokine Receptor Family ونشوف هذه الأنواع طبعا + +185 +00:16:07,420 --> 00:16:10,320 +Class One و Class Two Majority Of Receptors + +186 +00:16:10,320 --> 00:16:15,100 +Usually They Are Multimeric ويوم ما يصير فيه + +187 +00:16:15,100 --> 00:16:17,760 +ارتباط بالـ Receptors مايصير فيه Tyrosine + +188 +00:16:17,760 --> 00:16:22,180 +Phosphorylation عشان يعمل Signal Transduction زي + +189 +00:16:22,180 --> 00:16:25,780 +ما تشايفين هذا أول نوع Class One اللي هو الـ + +190 +00:16:25,780 --> 00:16:32,180 +Hemopoietin بيتكون من ريسبتور هذه الريسبتور تبعه ممكن + +191 +00:16:32,180 --> 00:16:37,820 +تكون Double Chain أو Triple Chain أو بتاري لكن شرط + +192 +00:16:37,820 --> 00:16:42,040 +أساسي يكون فيه Common Polypeptide Chain في هذا + +193 +00:16:42,040 --> 00:16:45,640 +الريسبتور وهي المسئولة عن اللي هو الـ Signal + +194 +00:16:45,640 --> 00:16:48,960 +Transduction شايفين الـ Legend هنا أكثر من واحد + +195 +00:16:48,960 --> 00:16:55,700 +أكثر من واحد كلهم مرتبطوا في هذا الريسبتور لكن + +196 +00:16:55,700 --> 00:17:02,320 +شوفوا على سبيل المثال ILGM-CSF-Receptor Subfamily + +197 +00:17:02,320 --> 00:17:10,200 +بيتكون من Double Chain Receptor لكن فيهم Common + +198 +00:17:10,200 --> 00:17:15,620 +Beta Subunits وهي نازلة Intracellular وهي + +199 +00:17:15,620 --> 00:17:23,060 +المسؤولة عن Signal Transduction أي مثل آخر IL-6 + +200 +00:17:23,060 --> 00:17:29,380 +Receptor Subfamily في Common Glycoprotein 130 أيضا + +201 +00:17:29,380 --> 00:17:34,580 +هو اللي مسئول على الـ Signal Transduction طبعا زي + +202 +00:17:34,580 --> 00:17:39,140 +ما اتفقنا أهدا IL-2 Receptor Subfamily في Common + +203 +00:17:39,140 --> 00:17:45,700 +Gamma Subunits لكن زي ما أنتم شايفين في Single في + +204 +00:17:45,700 --> 00:17:49,440 +Double Sorry Polypeptide وفي Triple Polypeptide و + +205 +00:17:49,440 --> 00:17:53,540 +بالمناسبة يوم يصير في ارتباط مع الـ Triple بتكون الـ + +206 +00:17:53,540 --> 00:17:59,040 +Affinity Of Binding أقوى بكثير من الـ Double أيوا + +207 +00:17:59,040 --> 00:18:09,920 +ماشي إن هي يوم يكون Single Polypeptide هي + +208 +00:18:09,920 --> 00:18:15,730 +في إن هي Cytokine IL3 5 GM CSF لكنها بما أنها Single + +209 +00:18:15,730 --> 00:18:22,210 +صار في Low Affinity في الـ Double الـ Affinity زادت + +210 +00:18:22,210 --> 00:18:26,730 +طبعا هذا زي ما أنتم شايفين الـ Single صحيح Single + +211 +00:18:26,730 --> 00:18:32,670 +لكن Common Polypeptide Chain هي واحدة هي الـ Alpha + +212 +00:18:32,670 --> 00:18:38,550 +Unicum Common طبعا Alpha جامعة الخير اللي شايفين + +213 +00:18:38,550 --> 00:18:41,990 +في Multiple Cytokine طابته بـ Receptor واحد Signal + +214 +00:18:41,990 --> 00:18:47,790 +Transduction بتكون واحدة لإيش لإن الـ Common Polymer + +215 +00:18:47,790 --> 00:18:56,110 +بتوع الـ Chain بتودي Common Signal وهنا طبعا الـ + +216 +00:18:56,110 --> 00:18:59,790 +Beta Sub Units زي ما أنتم شايفينها هي الـ Common + +217 +00:18:59,790 --> 00:19:08,930 +وبرضه حد يناقش Common Signal شايفين Same Signal في + +218 +00:19:08,930 --> 00:19:18,600 +الثلاثة ليش لأن هم يمتلكون الـ Share اللي + +219 +00:19:18,600 --> 00:19:24,320 +هو Polypeptide زي + +220 +00:19:24,320 --> 00:19:28,980 +ما أنتم شايفين الـ IL-3-O-GM-C-SF ممكن يرتبطوا + +221 +00:19:28,980 --> 00:19:37,630 +بريسيبتور مختلفة لكن هم يمتلكون كل الـ Share The + +222 +00:19:37,630 --> 00:19:43,430 +Same Sub Units وبالتالي الـ Signal هتكون The Same + +223 +00:19:43,430 --> 00:19:49,190 +طبعا هذه الـ Figure مبين إن الـ Affinity قوتها + +224 +00:19:49,190 --> 00:19:53,610 +مختلفة نفس الحكاية شايفين الـ Intermediate Affinity + +225 +00:19:53,610 --> 00:19:58,470 +Two Pre Peptide Chain لكن الـ Cytokine براني هن + +226 +00:19:58,470 --> 00:20:01,930 +High Affinity لأنه محدون الـ Cytokine وفي Triple + +227 +00:20:01,930 --> 00:20:03,770 +Chain هن Single + +228 +00:20:06,220 --> 00:20:15,280 +بالتالي الـ Affinity Is Low لأنه واحدة Receptor + +229 +00:20:15,280 --> 00:20:19,700 +ثاني اللي هو الـ Cytokine Class 2 Cytokine اللي + +230 +00:20:19,700 --> 00:20:27,080 +قلنا الـ Interferon برضه فيه 16 Residue في الـ + +231 +00:20:27,080 --> 00:20:31,100 +Cytokine وزي ما أنتم شايفين الـ Legend أكثر من + +232 +00:20:31,100 --> 00:20:31,520 +واحدة + +233 +00:20:34,470 --> 00:20:37,250 +هو آخر Family أخرى من الـ Receptor اللي هي + +234 +00:20:37,250 --> 00:20:40,210 +Immunoglobulin Superfamily زي ما أنتم شايفين في + +235 +00:20:40,210 --> 00:20:43,110 +أكثر من Domain لكن كلهم شرط أساسي في + +236 +00:20:43,110 --> 00:20:47,470 +Immunoglobulin Superfamily Gene Receptor إن هم + +237 +00:20:47,470 --> 00:20:52,530 +يحتووا على At Least Single Domain عشان من + +238 +00:20:52,530 --> 00:20:58,330 +Immunoglobulin Domain عشان يصير في Action + +239 +00:21:00,850 --> 00:21:04,890 +شايفين الـ Cysteine Double أكثر من Cysteine Residue + +240 +00:21:04,890 --> 00:21:11,390 +في الـ Tumor Necrosis Factor Receptor والـ Legend + +241 +00:21:11,390 --> 00:21:16,430 +أكثر من واحد هذا + +242 +00:21:16,430 --> 00:21:21,750 +الـ Chemical Receptors شايفين في Multiple Path في + +243 +00:21:21,750 --> 00:21:27,650 +Cell Membrane الـ Chemical بالمناسبة هو إن هو + +244 +00:21:27,650 --> 00:21:34,350 +الوحيد اللي بيرتبط بنشط الـ G-Protein كسيجنال أو + +245 +00:21:34,350 --> 00:21:37,950 +كميكال + +246 +00:21:37,950 --> 00:21:43,170 +ميسنجر في داخل الخلية شايفين كيف تم هذا المثال + +247 +00:21:43,170 --> 00:21:44,610 +حقيقي على الـ Signal Transduction + +248 +00:21:48,550 --> 00:21:52,810 +هذا عبارة عن الـ Receptor وزي ما تشوفون فيه + +249 +00:21:52,810 --> 00:21:58,350 +Intracellular Portion مرتبط جاكي بروتين جاكي + +250 +00:21:58,350 --> 00:22:03,490 +اللي هو عبارة عن Genes Activated Kinase Protein أي + +251 +00:22:03,490 --> 00:22:09,430 +ما ما صار فيه ارتباط بالـ Receptor بيصير فيه + +252 +00:22:09,430 --> 00:22:14,890 +Dimerization للـ Receptor ساعته كان ارتبط بياش بال + +253 +00:22:14,890 --> 00:22:19,730 +Double Chain شو بيصير؟ Dimerization ماشي ومتى ما + +254 +00:22:19,730 --> 00:22:21,830 +صار فيه Dimerization على طول بيصير فيه + +255 +00:22:21,830 --> 00:22:25,510 +Activation للجاك وطبعا هذه عبارة عن Energy Process + +256 +00:22:25,510 --> 00:22:31,410 +Energy-Demand Process بيصير فيه ATP فقدان للـ ATP + +257 +00:22:31,410 --> 00:22:36,370 +وفي نفس الوقت بيصير فيه Phosphorylation للجاك شو + +258 +00:22:36,370 --> 00:22:40,590 +بيعمل الجاك؟ بيجيب الجاك بنشط بروتين ثاني أو + +259 +00:22:40,590 --> 00:22:46,530 +Transcriptional Factor ثاني هو الستات ماشي Single + +260 +00:22:46,530 --> 00:22:53,850 +TransTranscription And Translation Protein هذا هو + +261 +00:22:53,850 --> 00:22:58,670 +الستاد اختصارا Single Transcription And + +262 +00:22:58,670 --> 00:23:04,410 +Translation Protein ايه حصل لفسفرةليشن طبعا تم + +263 +00:23:04,410 --> 00:23:08,150 +صار فيه الفسفرةليشن بيصل له Dimerization والاستاذ + +264 +00:23:08,150 --> 00:23:12,550 +إذا حصلت ديماريزيشن يدخل الداخل النيوكلياس وهناك + +265 +00:23:12,550 --> 00:23:17,430 +بيرتبط في الجينات المطلوب منها Transcription و + +266 +00:23:17,430 --> 00:23:21,970 +Translation عشان تنتجلي Action تنتجلي Protein صاحب + +267 +00:23:21,970 --> 00:23:27,790 +أي وظيفة هذا مثال حقيقي على الـ Signal Transduction + +268 +00:23:27,790 --> 00:23:32,630 +وزي ما أنتم شايفين أي ستات وجاك كل واحد له + +269 +00:23:32,630 --> 00:23:37,770 +وظيفته وكل واحد بنشط Certain Stat و Certain Jack + +270 +00:23:37,770 --> 00:23:42,410 +Can Only Incorporate On Their Action At The Same + +271 +00:23:42,410 --> 00:23:44,770 +Time فـ Jack واحد هان في الغامض أنا أنا أنا أنا أنا + +272 +00:23:44,770 --> 00:23:46,030 +أنا أنا أنا أنا أنا أنا أنا أنا أنا أنا أنا + +273 +00:23:46,030 --> 00:23:48,010 +أنا أنا أنا أنا أنا أنا أنا أنا أنا أنا أنا + +274 +00:23:48,010 --> 00:23:48,950 +أنا أنا أنا أنا أنا أنا أنا أنا أنا أنا أنا + +275 +00:23:48,950 --> 00:23:49,150 +أنا أنا أنا أنا أنا أنا أنا أنا أنا أنا أنا + +276 +00:23:49,150 --> 00:23:54,120 +أنا أنا أنا أنا أنا أنا أنا أنا أنا أنا ألف وبيتا + +277 +00:23:54,120 --> 00:24:01,400 +انترفيروين جاك واحد انتاروزين كينيز اثنين بنشطوا ستات + +278 +00:24:01,400 --> 00:24:07,440 +ايلتوا جاك واحد وجاك ثلاثة بنشطوا ستات فاف + +279 +00:24:11,600 --> 00:24:17,280 +العضلات الفيروسية ممكن تتعامل مع الـ Cytokine و + +280 +00:24:17,280 --> 00:24:22,140 +الهيئة الهيئة الهيئة الهيئة الهيئة الهيئة الهيئة + +281 +00:24:22,140 --> 00:24:27,260 +الهيئة الهيئة الهيئة + +282 +00:24:30,920 --> 00:24:38,680 +البرود بيفرز او ماكسوما فيروس بيفرز سوليو جاما + +283 +00:24:38,680 --> 00:24:46,180 +انترفيرون ريسبتور وهذا can bind the جاما انترفيرون + +284 +00:24:46,180 --> 00:24:51,400 +ريسبتور وبالتالي بعمل blocking لـ action of + +285 +00:24:51,400 --> 00:24:54,160 +cytokine والفيروس بي + +286 +00:24:56,820 --> 00:25:04,020 +نعنش يعني يوم تتنشط تير برا واحد تير برا اتنين يوم + +287 +00:25:04,020 --> 00:25:07,900 +تتنشط تير برا واحد تير برا اتنين زي ما قلنا عيالته + +288 +00:25:07,900 --> 00:25:11,640 +جامعة interferon human cross factor GM CSF + +289 +00:25:14,660 --> 00:25:20,980 +لكن تي البرتوب تحتاج لـ I L 4 I L 5 I L 10 I L 13 + +290 +00:25:20,980 --> 00:25:26,560 +طبعا هذه تنشط ميكروفيرد وهذه تنشط ميليم فور سايتس + +291 +00:25:28,940 --> 00:25:33,880 +وهي ال regulation كيف بتتم هي Macrophage ارتبطة + +292 +00:25:33,880 --> 00:25:43,420 +تبنيه تي CD4T-Helper Cell ماشي هي تفرز IL-2 بتنشط + +293 +00:25:43,420 --> 00:25:52,700 +ال ash نفسها و في نفس الوقت تبدأ تتنشطاللي هو أوطن + +294 +00:25:52,700 --> 00:25:59,120 +.. يعني ت .. سلة differentiation اما الاتيه البر + +295 +00:25:59,120 --> 00:26:01,940 +واحد او الاتيه البر اتنينطب كده في هذا الكلام + +296 +00:26:01,940 --> 00:26:05,700 +قالوا إذا فرضت I L 12 تشت تيهيلبر واحد وفي نفس + +297 +00:26:05,700 --> 00:26:11,300 +الوقت تيهيلبر واحد تطلع النجامة interferon اللي + +298 +00:26:11,300 --> 00:26:16,320 +بيعمل inhibition لذراع تيهيلبر 2 ونفس الحكاية إذا + +299 +00:26:16,320 --> 00:26:22,500 +I L 4 طلع نشط تيهيلبر 2 اللي بتطلع I L 4 و I L 5 و + +300 +00:26:22,500 --> 00:26:27,780 +I L 10 ماشي ال cytokine هذه و إذا فرضت I L 10 لعمل + +301 +00:26:27,780 --> 00:26:31,610 +inhibition لمين؟ لذراعته المرتوى + +302 +00:26:34,200 --> 00:26:38,420 +وهذا نفس الحكاية بس على مستوى transcriptional + +303 +00:26:38,420 --> 00:26:48,160 +factor I L 4 نشط Stat 6 نشط لي Gata 3 اللي عملت + +304 +00:26:48,160 --> 00:26:56,640 +inhibition لتيبة ماشي وبالتالي هذا هي نشطة I L 4 + +305 +00:26:56,640 --> 00:27:00,500 +على I L 5 وفي نفس الوقت عملت inhibition لجامعة + +306 +00:27:00,500 --> 00:27:07,090 +الفيرورفبالتالي طلع هذا كله و جف و مين اتنشطت + +307 +00:27:07,090 --> 00:27:11,910 +تيهيلبرتو نفس الحكاية يوم يكون في gamma interferon + +308 +00:27:11,910 --> 00:27:19,350 +طالع من الخلية ستة واحد مش ستة احد اتنشط اللي بنشط + +309 +00:27:19,350 --> 00:27:22,910 +ليه transcription factor اسمه TBET اللي بيعمل + +310 +00:27:22,910 --> 00:27:26,330 +inhibition لـ GATA3 و في نفس الوقت بيعمل inhibition + +311 +00:27:26,330 --> 00:27:31,710 +لـ IL4 على IL5 و بنشط ال gamma interferon فبتطلع ان + +312 +00:27:32,260 --> 00:27:39,240 +الـ T helper واحد منشطة كمان + +313 +00:27:39,240 --> 00:27:44,120 +لازم نذكر الـ T helper 17 و T reg cells التنتين + +314 +00:27:44,120 --> 00:27:52,020 +بالمناسبة CD4 T cell + +315 +00:27:52,020 --> 00:27:58,180 +بس واحدة Fox B positive و واحدة Fox B negative فما + +316 +00:27:58,180 --> 00:28:05,920 +تنتين CD4 ماشيهذه الوظيفة تعتبر الـ T-Helper 17 + +317 +00:28:05,920 --> 00:28:13,620 +لأنها تفرز الـ IL-17 تعتبر الـ T-Helper 17 تعتبر + +318 +00:28:13,620 --> 00:28:18,880 +الـ IL-17 تعتبر الـ IL-17بتطلع لنا IL-17 وهو + +319 +00:28:18,880 --> 00:28:22,560 +عدبارة عن الـ Pro-inflammatory cytokine وظيفته + +320 +00:28:22,560 --> 00:28:29,260 +الأساسية انه ينشط اللي هو يطلع لنا Pro + +321 +00:28:29,260 --> 00:28:33,040 +-inflammatory cytokine زي IL-6 بتطلعه من ال + +322 +00:28:33,040 --> 00:28:38,820 +fibroblasts و ال endothelial cells وبيعتبر ال + +323 +00:28:38,820 --> 00:28:42,900 +telbar cells بتعتبر كـ critical antibacterial + +324 +00:28:42,900 --> 00:28:48,810 +immunityليش؟ وبالذات هاه وبالذات it's associated + +325 +00:28:48,810 --> 00:28:52,050 +with rheumatoid arthritis بقى دي ال autoimmune + +326 +00:28:52,050 --> 00:28:56,950 +disease و ال SLE و myasthenia multiple sclerosis و + +327 +00:28:56,950 --> 00:29:04,550 +أزمة ال IL-17 ماشي و يعتبر pro-inflammatory يعني + +328 +00:29:04,550 --> 00:29:10,210 +بيعمل inflammation تيريج هي برنامج CD4 positive و + +329 +00:29:10,210 --> 00:29:17,470 +FOXP3 positiveغالبا تتكوّن في الـ Thymus وتعمل + +330 +00:29:17,470 --> 00:29:20,730 +انهيبشين لـ effector T cell development في الـ + +331 +00:29:20,730 --> 00:29:27,230 +lymph nodes و أيضا تتنش induced in periphery و + +332 +00:29:27,230 --> 00:29:30,010 +تتنش developed in periphery و تتنش developed under + +333 +00:29:30,010 --> 00:29:33,250 +the influence of transformed growth factor beta + +334 +00:29:33,250 --> 00:29:35,490 +تتنش انهيبش انهيبش انهيبش انهيبش انهيبش انهيبش + +335 +00:29:35,490 --> 00:29:36,310 +انهيبش انهيبش انهيبش انهيبش انهيبش انهيبش انهيبش + +336 +00:29:36,310 --> 00:29:39,550 +انهيبش انهيبش انهيبش انهيبش انهيبش انهيبش انهيبش + +337 +00:29:41,540 --> 00:29:49,400 +هذه نفس الحكاية تي هيلبردفرانشيشن تيهيلبردوالف + +338 +00:29:49,400 --> 00:29:51,680 +تيهيلبردوالف تيهيلبردوالف تيهيلبردوالف + +339 +00:29:51,680 --> 00:29:53,280 +تيهيلبردوالف تيهيلبردوالف تيهيلبردوالف + +340 +00:29:53,280 --> 00:29:54,700 +تيهيلبردوالف تيهيلبردوالف تيهيلبردوالف + +341 +00:29:54,700 --> 00:29:56,800 +تيهيلبردوالف تيهيلبردوالف تيهيلبردوالف + +342 +00:29:56,800 --> 00:30:02,760 +تيهيلبردوالف تيهيلبردوالف تيهيلبردوالف + +343 +00:30:02,760 --> 00:30:08,400 +تيهيلبردوالف تيهيلبردوالف تيهيلبردوالف + +344 +00:30:08,400 --> 00:30:11,180 +تيهيلبردوالف تيهيلبردوالف تيهيلبردوالف تيهيلبرعمل + +345 +00:30:11,180 --> 00:30:16,580 +انهيبش اللي فوق في نفس الوقت صار فيها نتيجة + +346 +00:30:16,580 --> 00:30:26,100 +البرتوق activity aisle 23 aisle 2 بنشت اللي هو ال + +347 +00:30:27,830 --> 00:30:33,610 +التي هي البرسيل اللي هي بتطلع انها IL-17 وهذا + +348 +00:30:33,610 --> 00:30:39,170 +عبارة عن اللي هو Pro-inflammatory-cytokine بتطلع + +349 +00:30:39,170 --> 00:30:45,410 +من الخلايا هذه Regulation of cytokine جاله اما باي + +350 +00:30:45,410 --> 00:30:51,640 +كرماتين Structureتوقف ال expression of the + +351 +00:30:51,640 --> 00:30:55,360 +chromatin structure و ال cytokine therapy احنا + +352 +00:30:55,360 --> 00:30:59,360 +ممكن نستخدمها في ال therapy ببساطة by using + +353 +00:30:59,360 --> 00:31:03,180 +antibody that + +354 +00:31:03,180 --> 00:31:08,040 +block the receptor وبالتالي بتعمل inhibition لل + +355 +00:31:08,040 --> 00:31:12,080 +action of IL-2 يعني يطلع ال action of IL-2 لكن + +356 +00:31:12,080 --> 00:31:15,180 +احنا استخدمنا antibody that block the receptor of + +357 +00:31:15,180 --> 00:31:19,790 +IL-2 وبالتالي بطل يشتغلالـ IL-2 وبالتالي هذا مفيد + +358 +00:31:19,790 --> 00:31:24,510 +في حالات ال autoimmune disease على سبيل المثال لما + +359 +00:31:24,510 --> 00:31:32,870 +بيتوقف ال immune response ايضا ممكن استخدم IL-2 + +360 +00:31:32,870 --> 00:31:38,640 +analogبينافس الـ IL-2 في الارتباط بالرسيبتور + +361 +00:31:38,640 --> 00:31:43,200 +وبالتالي إذا ارتبط ال IL-2 لما يجي مش راح يلاقي + +362 +00:31:43,200 --> 00:31:49,380 +الرسيبتور مشغول و برضه مش راح يشتغل Destruction of + +363 +00:31:49,380 --> 00:31:56,550 +activated T-Liposyl ببساطة احنا ممكنان مربط تكسين + +364 +00:31:56,550 --> 00:32:02,130 +الـ cytokine بيتوكسين وبالتالي اول ما يرتبط + +365 +00:32:02,130 --> 00:32:06,530 +بالرسيبتور اللى على سطح الـ T-Helper cell بعمل + +366 +00:32:06,530 --> 00:32:14,210 +destruction للخلية نفسها ودى قائمة بانواع ال + +367 +00:32:14,210 --> 00:32:22,580 +cytokine اللى بتستخدم in clinical useوبهيك اتمنى + +368 +00:32:22,580 --> 00:32:31,740 +ان اكون غطيت المحاضرة مع تمانياتيلكم بالإيش بالفهم + +369 +00:32:31,740 --> 00:32:32,200 +الجيد diff --git a/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/s4m5oI817q8_postprocess.srt b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/s4m5oI817q8_postprocess.srt new file mode 100644 index 0000000000000000000000000000000000000000..8a4094944f5bcd0401b1b26aef39a9de21b7530f --- /dev/null +++ b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/s4m5oI817q8_postprocess.srt @@ -0,0 +1,1476 @@ +1 +00:00:02,060 --> 00:00:05,180 +بسم الله الرحمن الرحيم حضرتنا اليوم ان شاء الله عن + +2 +00:00:05,180 --> 00:00:14,440 +ال cytokine و cytokine تعريفا هي برهان مجموعة من + +3 +00:00:14,440 --> 00:00:21,280 +ال chemical messenger وظائفها + +4 +00:00:21,280 --> 00:00:25,860 +نمر واحد مدية and regulate the immune system و + +5 +00:00:25,860 --> 00:00:30,000 +بتعمل regulation لل immune systemان صفاتها ان + +6 +00:00:30,000 --> 00:00:33,880 +their secretion is brief and self-limited لحالة + +7 +00:00:33,880 --> 00:00:40,540 +نمرة تلاتة individual cytokine can produce by + +8 +00:00:40,540 --> 00:00:44,800 +multiple cell type يعني اكتر من خلية كان ممكن + +9 +00:00:44,800 --> 00:00:51,650 +تعطينا هذه ال cytokineكمان من صفاته انه act of + +10 +00:00:51,650 --> 00:00:56,450 +multiple cell types يعني pleiotropic الـ + +11 +00:00:56,450 --> 00:01:03,090 +pleiotropism ان one cytokine ممكن يشتغل على اكتر + +12 +00:01:03,090 --> 00:01:09,690 +من خلية وهذا مثال حي على ذلك هي activated T-helper + +13 +00:01:09,690 --> 00:01:16,110 +cell شايفين الـ pleiotropy طلع لنا آية 4 اللي ممكن + +14 +00:01:16,930 --> 00:01:23,670 +يشتغل على بيلمفوسايتز على ثايموسايتز وعلى muscle + +15 +00:01:23,670 --> 00:01:31,870 +وطبعا نعرف احنا انه its action او ال end result of + +16 +00:01:31,870 --> 00:01:35,310 +its action اللي هو proliferation and + +17 +00:01:35,310 --> 00:01:39,630 +differentiation for these cells يبقى زي ما انتوا + +18 +00:01:39,630 --> 00:01:43,980 +شايفين one cytokine can act on different cellsThey + +19 +00:01:43,980 --> 00:01:48,980 +are also redundant بمعنى ان multiple cytokines can + +20 +00:01:48,980 --> 00:01:57,040 +act on one cell ماشي and multiple cytokines يعني + +21 +00:01:57,040 --> 00:02:00,880 +different cytokines may have the same effect on + +22 +00:02:00,880 --> 00:02:06,300 +target cell واحدة بيسموهم redundant اللي هو + +23 +00:02:06,300 --> 00:02:11,400 +التكراروطبعا زي ما انت شايفين IL-245 بيشتغلوا على + +24 +00:02:11,400 --> 00:02:16,040 +B-lymphocyte طالعين من B من T cell T البرسيل عملوا + +25 +00:02:16,040 --> 00:02:22,660 +proliferation for B-lymphocytes ايضا من صفاتهم ان + +26 +00:02:22,660 --> 00:02:28,960 +they can affect the synthesis of each other واحد + +27 +00:02:28,960 --> 00:02:35,800 +ممكن يأثر على تكوين التاني او انتاج التانيايضا ال + +28 +00:02:35,800 --> 00:02:41,040 +synergism ال synergistic اللي هو اتنين او اكتر + +29 +00:02:41,040 --> 00:02:49,420 +cytokine may have greater than additive effect + +30 +00:02:49,420 --> 00:03:00,380 +اتنين بيساعدوا و بدون ايش تأثير اضافي على الخليةأو + +31 +00:03:00,380 --> 00:03:04,380 +Antagonism بمعنى أن واحد ممكن يشتغل ضد التاني واحد + +32 +00:03:04,380 --> 00:03:08,660 +ممكن يشتغل ضد التاني وهذه أمثلة على ذلك على ال + +33 +00:03:08,660 --> 00:03:13,200 +scenario هي IL-4 و IL-5 يشتغلوا على بالينفسيز و + +34 +00:03:13,200 --> 00:03:19,940 +قدوا إلها إنتاج ال IGE عملوا class switchingبينما + +35 +00:03:19,940 --> 00:03:24,080 +في الانتاجونيزم زي ما انتوا شايفين ال IELTS 4 منتج + +36 +00:03:24,080 --> 00:03:30,060 +من ال activity ال برسيل عشان ينشطلي مين اللي هو + +37 +00:03:30,060 --> 00:03:34,320 +بالينفوسايد فأجى الجامعة انترفيرون وعمل بلاكينج لل + +38 +00:03:34,320 --> 00:03:39,860 +IELTS 4 وبالتالي منع اللي هو ال class switching of + +39 +00:03:39,860 --> 00:03:43,060 +IGE اللي بدو ينتج + +40 +00:03:45,950 --> 00:03:51,910 +أيضا ال cytokine can act in a cascade يعني ال + +41 +00:03:51,910 --> 00:03:59,550 +additive effect أو محصلة اللي هو عمل ال cytokine + +42 +00:03:59,550 --> 00:04:08,070 +ممكن نشوفها على شكل cascade و بيسموا هذا التفاعل + +43 +00:04:08,070 --> 00:04:11,910 +cascade action + +44 +00:04:13,120 --> 00:04:17,120 +فهي على سبيل المثال او cascade induction هى على + +45 +00:04:17,120 --> 00:04:20,220 +سبيل المثال اكتفيت تيهيلبرسيل طلعت لنا gamma + +46 +00:04:20,220 --> 00:04:24,580 +interferon نشرت macro phage طلعت ال macro phage IL + +47 +00:04:24,580 --> 00:04:30,440 +-12 اللى ايضا اشتغل على تيهيلبرسيل اكتفيته وادتني + +48 +00:04:30,440 --> 00:04:34,420 +gamma interferon human necrosis factor IL-2 and + +49 +00:04:34,420 --> 00:04:38,980 +other cytokines ال action can be induced in a + +50 +00:04:38,980 --> 00:04:44,770 +cascade mannerالـ cytokine أيضًا من صفاتها إنه + +51 +00:04:44,770 --> 00:04:50,190 +they can act as a hormone فممكن يشتغلوا ك in + +52 +00:04:50,190 --> 00:04:54,770 +autocrine action or paracrine action or endocrine + +53 +00:04:54,770 --> 00:04:58,750 +action ال autocrine إنه الخلية ممكن تشتغل على + +54 +00:04:58,750 --> 00:05:04,470 +نفسها ال paracrine على nearby cell ال endocrineon + +55 +00:05:04,470 --> 00:05:08,570 +a distant cell بمعنى blood circulation لغاية نفس + +56 +00:05:08,570 --> 00:05:16,770 +الخلية المطلوبة و هناك يؤثر عليها الخلية + +57 +00:05:16,770 --> 00:05:20,800 +التي تفرز هذه الـ cytokine and their functionقالوا + +58 +00:05:20,800 --> 00:05:24,280 +في مجموعة كبيرة من الخلايا capable of making + +59 +00:05:24,280 --> 00:05:28,360 +cytokine لكن أشهر هذه الخلايا هي ميكروفيجو + +60 +00:05:28,360 --> 00:05:35,200 +والتيهير برسل ال their action involved in many + +61 +00:05:35,200 --> 00:05:39,500 +area منها ال hematopoiesis ال adaptive immunity ال + +62 +00:05:39,500 --> 00:05:43,940 +نهيط immunity ال inflammation وطبعا their activity + +63 +00:05:43,940 --> 00:05:49,610 +can be established in vitroby recombinant cytokine + +64 +00:05:49,610 --> 00:05:56,410 +which can be used as a therapeutic agent in vivo + +65 +00:05:56,410 --> 00:06:03,230 +طيب صفات العامة لـ cytokine قالوا زي ما اتفقنا + +66 +00:06:03,230 --> 00:06:09,030 +ممكن يشتغل على innate immunity بعضهمو طبعا في هذا + +67 +00:06:09,030 --> 00:06:11,790 +الحالة بيشتغلوا على الـ Mononuclear phagocyte في + +68 +00:06:11,790 --> 00:06:15,750 +الـ innate immunity أهم شيء ال phagocytic cell in + +69 +00:06:15,750 --> 00:06:19,830 +response to infection فبيشتغلوا كيف؟ بيشتغلوا على + +70 +00:06:19,830 --> 00:06:23,710 +ال endothelial cell which linesBlood vessels + +71 +00:06:23,710 --> 00:06:27,630 +وبالتالي بيعملوا لها activation فبيصير فيه + +72 +00:06:27,630 --> 00:06:32,410 +Retraction لهذه الخلايا وبالتالي مما يسمح بانزلاق + +73 +00:06:32,410 --> 00:06:37,190 +ال neutrophil من داخل ال blood vessels إلى خارجها + +74 +00:06:37,190 --> 00:06:41,730 +بينجوسين انه they can act in leukocyte activation + +75 +00:06:41,730 --> 00:06:50,590 +طبعا هذه حاجة مثال على ده الكتابة microcess factor + +76 +00:06:52,050 --> 00:06:54,570 +which can cause endothelial cell to produce a + +77 +00:06:54,570 --> 00:07:00,390 +digestive molecule طبعا لمين للإنفسايت and secret + +78 +00:07:00,390 --> 00:07:18,010 +chemokine طالعة من هنا مثل + +79 +00:07:18,010 --> 00:07:20,410 +آخر الآية ال seven زي ال human + +80 +00:07:24,080 --> 00:07:29,580 +Gamma interferon وهذا معروف انه بيعمل activation + +81 +00:07:29,580 --> 00:07:35,640 +للميكروفير معتني من او من وظائفهم الأخرى انه كان + +82 +00:07:35,640 --> 00:07:41,840 +ساعته كان كان Mediate the action of adaptive + +83 +00:07:41,840 --> 00:07:47,440 +immune system and regulated في نفس الوجودطبعا ده + +84 +00:07:47,440 --> 00:07:50,920 +مطلع غالبا الـ cytokine من الـ T lymphocyte و T + +85 +00:07:50,920 --> 00:07:54,540 +lymphocyte احنا عارفين T البرسيل اللي هي ال + +86 +00:07:54,540 --> 00:07:58,620 +orchestrate cell في ال adaptive immune cell اللي + +87 +00:07:58,620 --> 00:08:04,780 +هي من توزع المهام على خلايا كثيرة طبعا ال + +88 +00:08:04,780 --> 00:08:07,680 +lymphocyte can also induce growth and + +89 +00:08:07,680 --> 00:08:14,510 +differentiation during their activationو بيطلع لنا + +90 +00:08:14,510 --> 00:08:17,010 +في النهاية effector cell و memory cell من ال + +91 +00:08:17,010 --> 00:08:19,930 +effector cell اللي ممكن تتنشر اللي هي ال + +92 +00:08:19,930 --> 00:08:24,970 +phagocytic cell زي ال neutrophil و xenophil و ال + +93 +00:08:24,970 --> 00:08:33,370 +other adaptive immune cells قسموها إلى activator + +94 +00:08:33,370 --> 00:08:38,990 +of cytotoxic response بمعنى adaptive طبعابمعنى انه + +95 +00:08:38,990 --> 00:08:47,450 +تنشيط الـ cytotoxic cell T cell والان K cell اهم + +96 +00:08:47,450 --> 00:08:52,170 +ال cytokine بتطلع من هذه المجموعة هي IL-2 IL-3 + +97 +00:08:52,170 --> 00:08:58,350 +طبعا كلنا بنعرف ال IL-2 هو عبارة عن T cell و ال + +98 +00:08:58,350 --> 00:09:02,790 +cytokine بتطلع منها و بنشطها في نفس الوقت IL-3 هو + +99 +00:09:02,790 --> 00:09:05,610 +عبارة عن father of cytokine بيشتغل اكتر من خلية من + +100 +00:09:05,610 --> 00:09:11,670 +ضمنهم هذه الخلاياجامعة Interferon زي و زي هي + +101 +00:09:11,670 --> 00:09:12,250 +قالتوا + +102 +00:09:14,730 --> 00:09:18,010 +Lymphotoxin زي و زي ال human necrosis factors زي + +103 +00:09:18,010 --> 00:09:22,130 +ما طوي شوفنا Can induce fever و Can mediate + +104 +00:09:22,130 --> 00:09:27,150 +chemotaxis او ككيموتاكتك في الهيجانز وبالتالي في + +105 +00:09:27,150 --> 00:09:31,170 +علاقة مباشرة ما بين ال adaptive و ال innate immune + +106 +00:09:31,170 --> 00:09:37,190 +responseهي activator ل ال humoral response + +107 +00:09:37,190 --> 00:09:41,770 +induction of B cell activation احنا عارفين B cell + +108 +00:09:42,050 --> 00:09:46,990 +هي الـ humoral response و بعدها تبين immunity + +109 +00:09:46,990 --> 00:09:54,230 +طلعنا antibody humoral part من أشهر هذه ال + +110 +00:09:54,230 --> 00:10:01,910 +cytokine في هذه المجموعة IL-2الو بيطلع من ال T + +111 +00:10:01,910 --> 00:10:07,030 +cell و بيعمل بيأثر على ال B lymphocyte آية التلاتة + +112 +00:10:07,030 --> 00:10:11,590 +قولنا father آية الأربعة زي و زي اتنين في وجود + +113 +00:10:11,590 --> 00:10:20,110 +خمسة بيدينا IGA و الخمسة لحاله IGA ستة ممكن يعمل B + +114 +00:10:20,110 --> 00:10:23,350 +cell differentiation to plasma cell transforming + +115 +00:10:23,350 --> 00:10:26,670 +growth factor beta هذا عبارة عن inhibitory + +116 +00:10:26,670 --> 00:10:31,640 +cytokine gamma interferonهو بقى بيعمل switching to + +117 +00:10:31,640 --> 00:10:38,980 +IgG instead of IgM المجموعة التالتة هي activator + +118 +00:10:38,980 --> 00:10:43,320 +of inflammation or inflammatory cells و طبعا هذا + +119 +00:10:43,320 --> 00:10:47,700 +type 2 interferon او ال gamma interferon هو بره ان + +120 +00:10:47,700 --> 00:10:51,620 +inflammatory cytokine can be released during + +121 +00:10:51,620 --> 00:10:59,100 +activation of phagocytic cellمو اخر من ال function + +122 +00:10:59,100 --> 00:11:03,900 +لل cytokine هي simulator of hemopoiesis و طبعا + +123 +00:11:03,900 --> 00:11:08,180 +كلنا بنعرف hemopoiesis يعني تنشيط إمتاج خلايا الدم + +124 +00:11:08,180 --> 00:11:13,060 +و احنا عارفين ان كل خلية من خلايا الدم عشان تنتقل + +125 +00:11:13,060 --> 00:11:18,820 +من ال immature ال mature تحتاج ال cytokineعشان + +126 +00:11:18,820 --> 00:11:22,640 +تنوجد من الأساس تحتاج ال growth factor وفي أنواع + +127 +00:11:22,640 --> 00:11:26,200 +كثيرة من هذه ال cytokine زي IL 3 أو 7 أو colon + +128 +00:11:26,200 --> 00:11:32,320 +stimulating factor و GMCSF و MCSF و GCSF كلها + +129 +00:11:32,320 --> 00:11:37,680 +عبارة عن colon stimulating factor ال cytokine + +130 +00:11:40,090 --> 00:11:45,330 +أيضا زى ما اتفقنا انه بشتغل كان ممكن الوملي كلها + +131 +00:11:45,330 --> 00:11:48,810 +الوظائف اللى احنا حكينا عليها توى فمنها على سبيل + +132 +00:11:48,810 --> 00:11:54,330 +مثال هيوشن سايتوكاين في حالة التنشيط الماكروفيش + +133 +00:11:54,330 --> 00:11:58,600 +طلع سايتوكاين تعمل نشطة ال hemopoiesisبتطلع + +134 +00:11:58,600 --> 00:12:03,000 +cytokine can activate T-Helper cell بتنشط طلع + +135 +00:12:03,000 --> 00:12:06,880 +cytokine يوم ما ترتبط فيها أو تقدم ال antigen لل T + +136 +00:12:06,880 --> 00:12:10,700 +-Helper cell resting T-Helper cell ممكن تتنشطها + +137 +00:12:10,700 --> 00:12:14,420 +طبعا يوم ما تتنشط ال resting T-Helper cell و تتحول + +138 +00:12:14,420 --> 00:12:18,590 +ل activated بتنشط ال macrophage مرة تانيةالـ + +139 +00:12:18,590 --> 00:12:21,230 +macrophage يوم ما تتنشط كمان الـ Adaptive Immune + +140 +00:12:21,230 --> 00:12:27,770 +System يمكن أن يكون اكتفيت و كلهم يمكن أن يؤدوا + +141 +00:12:27,770 --> 00:12:32,590 +الى Inflammatory Reaction أي يوم ما تتنشط و تتعدي + +142 +00:12:32,590 --> 00:12:36,710 +وبالتالي الـ cytokine يمكن أن يسيطر عملية عملية + +143 +00:12:36,710 --> 00:12:39,030 +عملية عملية عملية عملية عملية عملية عملية عملية + +144 +00:12:39,030 --> 00:12:45,910 +عملية عملية عملية عملية عملية عملية + +145 +00:12:45,910 --> 00:12:49,150 +عملية عملية عملية عملية عملية عملية عمليةكل واحد + +146 +00:12:49,150 --> 00:12:53,450 +من وين بيطلع و إيش وظيفته طبعا مش مطالبين بالحفظ + +147 +00:12:53,450 --> 00:12:58,630 +بس ضروري تعرفوا الـ measure type هذه صورة الـ + +148 +00:12:58,630 --> 00:13:02,670 +hemopoietic tree و زي ما اتفقنا كل خطوة من الخطوات + +149 +00:13:02,670 --> 00:13:07,350 +تحتاج إلى سايتو كان عشان يدخل الخلية من مرحلة إلى + +150 +00:13:07,350 --> 00:13:14,000 +أخرىالـ cytokines are non specific و احنا طبعا طوأ + +151 +00:13:14,000 --> 00:13:17,640 +شوفنا ان هم they are non specific اكتر من cytokine + +152 +00:13:17,640 --> 00:13:21,220 +بيشتغل على خلية ال cytokine بيشتغل على واحد بيشتغل + +153 +00:13:21,220 --> 00:13:26,420 +على اكتر من خلية طبعا كيف انه ال cytokine are non + +154 +00:13:26,420 --> 00:13:29,940 +specific و في نفس الوقت ال immune system is + +155 +00:13:29,940 --> 00:13:32,720 +specific ماشي + +156 +00:13:34,080 --> 00:13:37,800 +How does immune specificity fit with non-specific + +157 +00:13:37,800 --> 00:13:40,960 +cytokine؟ كيف ممكن تفسير هذه الظاهرة؟ جالو ال + +158 +00:13:40,960 --> 00:13:47,160 +answer نمرة واحد through receptor ال receptor اللي + +159 +00:13:47,160 --> 00:13:52,520 +موجودة على ال antigen activated cell هي فقط ترتبط + +160 +00:13:52,520 --> 00:13:57,230 +بال certain cytokine نمرة اتنينclose proximity + +161 +00:13:57,230 --> 00:14:03,290 +بمعنى ان الخلايا اللى جنب وجودها بجوار بعض بتدى + +162 +00:14:03,290 --> 00:14:11,250 +الى اللى هو تفاعل او وجود ال cytokine او وصول ال + +163 +00:14:11,250 --> 00:14:16,880 +cytokine من شغلها الى الأخرىأحسن مثال على ذلك وجود + +164 +00:14:16,880 --> 00:14:20,440 +الانتجن presenting cell كيف يتقدم الانتجن اللتي هي + +165 +00:14:20,440 --> 00:14:23,380 +البرسيلة وبالتالي بيصير فيه ارتباط ما بين هذه و + +166 +00:14:23,380 --> 00:14:30,480 +هذه .. both cells و .. و متى ما صار ارتباط بيصير + +167 +00:14:30,480 --> 00:14:38,900 +في cytokine release concentration of cytokine are + +168 +00:14:38,900 --> 00:14:40,140 +locally high + +169 +00:14:45,040 --> 00:14:48,460 +ولوكاليا و يوم ما يحصل في ارتباط فقط ال antigen + +170 +00:14:48,460 --> 00:14:54,460 +presenting cell هي اللي بتتنشط الاجابة + +171 +00:14:54,460 --> 00:14:57,680 +الثالثة على هذا السؤال انه they have short half + +172 +00:14:57,680 --> 00:15:03,240 +life و short half life ensure that local activity + +173 +00:15:03,240 --> 00:15:10,060 +of the cytokineهي مثال على ذلك هي عبارة عن خلية + +174 +00:15:10,060 --> 00:15:16,200 +صارت نشطت صار في stimulus inducing stimulus طلعت + +175 +00:15:16,200 --> 00:15:20,740 +لما اتنشطت طلعت لنا cytokine و ال cytokine ايجي + +176 +00:15:20,740 --> 00:15:26,340 +على ال nearby cell و ارتبط بال specific receptor + +177 +00:15:26,340 --> 00:15:29,780 +اللي هو for this cytokine طبعا متى ما صار في + +178 +00:15:29,780 --> 00:15:34,660 +ارتباط بيصير في biological effectالسايتو كاي + +179 +00:15:34,660 --> 00:15:38,940 +ريسبتور لأ لو فيه خمس ميجار family للسايتو كاي + +180 +00:15:38,940 --> 00:15:43,240 +ريسبتور نمر واحد immunoglobulin superfamily نمر + +181 +00:15:43,240 --> 00:15:48,040 +اتنين hemopoietin receptor بيسموهم class one type + +182 +00:15:48,040 --> 00:15:54,140 +ثم interferon receptor او بيسموهم class two type + +183 +00:15:54,140 --> 00:16:00,720 +يعني و ثم human cross factor receptor family ثم + +184 +00:16:00,720 --> 00:16:07,420 +chemokine receptor familyونشوف هذه الأنواع طبعا + +185 +00:16:07,420 --> 00:16:10,320 +class one و class two majority of receptors + +186 +00:16:10,320 --> 00:16:15,100 +usually they are multimeric ويوم ما يصير فيه + +187 +00:16:15,100 --> 00:16:17,760 +ارتباط بالreceptors مايصير فيه tyrosine + +188 +00:16:17,760 --> 00:16:22,180 +phosphorylation عشان يعمل signal transduction زي + +189 +00:16:22,180 --> 00:16:25,780 +ما تشايفين هذا أول نوع class one اللي هو ال + +190 +00:16:25,780 --> 00:16:32,180 +hemopoietinبيتكون من رسبتور هذه الرسبتور تبعه ممكن + +191 +00:16:32,180 --> 00:16:37,820 +تكون double chain او triple chain او بتاري لكن شرط + +192 +00:16:37,820 --> 00:16:42,040 +اساسي يكون فيه common polypeptide chain في هذا + +193 +00:16:42,040 --> 00:16:45,640 +الرسبتور وهي المسئولة عن اللي هو ال signal + +194 +00:16:45,640 --> 00:16:48,960 +transduction شايفين ال legend هنا اكتر من واحد + +195 +00:16:48,960 --> 00:16:55,700 +اكتر من واحد كلهم مرتبطوا في هذا الرسبتور لكن + +196 +00:16:55,700 --> 00:17:02,320 +شوفواعلى سبيل المثال ILGM-CSF-Receptor Subfamily + +197 +00:17:02,320 --> 00:17:10,200 +بيتكون من Double Chain Receptor لكن فيهم Common + +198 +00:17:10,200 --> 00:17:15,620 +Beta Subunits وهي نازلة Intracytoplasmic وهي + +199 +00:17:15,620 --> 00:17:23,060 +المسؤولة عن Signal Transduction أي مثل آخر IL-6 + +200 +00:17:23,060 --> 00:17:29,380 +Receptor Subfamilyفي common glycoprotein 130 ايضا + +201 +00:17:29,380 --> 00:17:34,580 +هو اللي مسئول على ال signal transduction طبعا زي + +202 +00:17:34,580 --> 00:17:39,140 +ما اتفقنا اهدا IL-2 receptor subfamily في common + +203 +00:17:39,140 --> 00:17:45,700 +gamma subunits لكن زي ما انتوا شايفين في singleفي + +204 +00:17:45,700 --> 00:17:49,440 +double sorry polypeptide وفي triple polypeptide و + +205 +00:17:49,440 --> 00:17:53,540 +بالمناسبة يوم يصير في ارتباط مع ال triple بتكون ال + +206 +00:17:53,540 --> 00:17:59,040 +affinity of binding اقوى بكثير من ال double ايو + +207 +00:17:59,040 --> 00:18:09,920 +ماشي انها يوم يكون single polypeptide هي + +208 +00:18:09,920 --> 00:18:15,730 +في انها cytokine IL3 5 GM CSFلكنها بما انها single + +209 +00:18:15,730 --> 00:18:22,210 +صار فى low affinity فى ال double ال affinity زادت + +210 +00:18:22,210 --> 00:18:26,730 +طبعا هذا زى ما انتوا شايفين ال single صحيح single + +211 +00:18:26,730 --> 00:18:32,670 +لكن common polypeptide chain هى واحدة هى ال alpha + +212 +00:18:32,670 --> 00:18:38,550 +Unicum common طبعا alpha جامعة الخير اللى شايفين + +213 +00:18:38,550 --> 00:18:41,990 +فى multiple cytokine طابته ب receptor واحد signal + +214 +00:18:41,990 --> 00:18:47,790 +transductionبتكون واحدة لإيش لإن ال common polymer + +215 +00:18:47,790 --> 00:18:56,110 +بتوع ال chain بتودي common signal وهنا طبعا ال + +216 +00:18:56,110 --> 00:18:59,790 +beta sub units زي ما انتوا شايفينها هي ال common + +217 +00:18:59,790 --> 00:19:08,930 +وبرضه حد يناقش common signal شايفين same signal في + +218 +00:19:08,930 --> 00:19:18,600 +التلاتة ليشلأن هما يمتلقون الـ Share اللي + +219 +00:19:18,600 --> 00:19:24,320 +هو Polypeptide زي + +220 +00:19:24,320 --> 00:19:28,980 +ما انتوا شايفين الـ IL-3-O-GM-C-SF ممكن يرتبطوا + +221 +00:19:28,980 --> 00:19:37,630 +برسيبتور مختلفة لكن هم يمتلقون كل الـ Sharethe + +222 +00:19:37,630 --> 00:19:43,430 +same sub units وبالتالي ال signal هتكون the same + +223 +00:19:43,430 --> 00:19:49,190 +طبعا هذه ال figure مبين ان ال affinity قوتها + +224 +00:19:49,190 --> 00:19:53,610 +مختلفة نفس الحكاية شايفين ال intermediate affinity + +225 +00:19:53,610 --> 00:19:58,470 +two pre peptide chain لكن ال cytokine براني هن + +226 +00:19:58,470 --> 00:20:01,930 +high affinity لأنه محدون ال cytokine وفي triple + +227 +00:20:01,930 --> 00:20:03,770 +chain هن single + +228 +00:20:06,220 --> 00:20:15,280 +بالتالي الـ affinity is low لأنه واحدة Receptor + +229 +00:20:15,280 --> 00:20:19,700 +تاني اللي هو الـ cytokine class 2 cytokine اللي + +230 +00:20:19,700 --> 00:20:27,080 +قولنا ال interferon برضه فيه 16 residue في ال + +231 +00:20:27,080 --> 00:20:31,100 +cytokine وزي ما انتوا شايفين ال legend أكتر من + +232 +00:20:31,100 --> 00:20:31,520 +واحدة + +233 +00:20:34,470 --> 00:20:37,250 +هو اخر family اخرى من ال receptor اللى هى + +234 +00:20:37,250 --> 00:20:40,210 +immunoglobulin superfamily زى ما انتوا شايفين فى + +235 +00:20:40,210 --> 00:20:43,110 +اكتر من domain لكن كلهم شرط اساسى فى + +236 +00:20:43,110 --> 00:20:47,470 +immunoglobulin superfamily gene receptor ان هم + +237 +00:20:47,470 --> 00:20:52,530 +يحتويوا على at least single domain عشان من + +238 +00:20:52,530 --> 00:20:58,330 +immunoglobulin domain عشان يسير فى action + +239 +00:21:00,850 --> 00:21:04,890 +شايفين الـ cysteine دابل اكتر من cysteine residue + +240 +00:21:04,890 --> 00:21:11,390 +في ال tumor necrosis factor receptor و ال legend + +241 +00:21:11,390 --> 00:21:16,430 +اكتر من واحد هذا + +242 +00:21:16,430 --> 00:21:21,750 +ال chemical receptors شايفين في multiple path في + +243 +00:21:21,750 --> 00:21:27,650 +cell membrane ال chemical in بالمناسبة هو ان هو + +244 +00:21:27,650 --> 00:21:34,350 +الوحيد اللي برتبطبنشط الـ G-protein كسيجنال أو + +245 +00:21:34,350 --> 00:21:37,950 +كميكال + +246 +00:21:37,950 --> 00:21:43,170 +مسينجر في داخل الخلية شايفين كيف تم هذا المثال + +247 +00:21:43,170 --> 00:21:44,610 +حقيقي على الـ Signal Transduction + +248 +00:21:48,550 --> 00:21:52,810 +هذا عبارة عن الـ Receptor وزي ما تشوفون فيه + +249 +00:21:52,810 --> 00:21:58,350 +Intracytoplasmic portion مرتبط جاكي بروتين جاكي + +250 +00:21:58,350 --> 00:22:03,490 +اللي هو عبارة عن Genes Activated Kinase Protein أي + +251 +00:22:03,490 --> 00:22:09,430 +مات ما صار فيه ارتباط بال Receptor بيصير فيه + +252 +00:22:09,430 --> 00:22:14,890 +Diamerization لل Receptor ساعته كان ارتبط بياش بال + +253 +00:22:14,890 --> 00:22:19,730 +Double Chain شو بيصير؟ Diamerizationماشي ومتى ما + +254 +00:22:19,730 --> 00:22:21,830 +صار فيه Diaminalization على طول بيصير فيه + +255 +00:22:21,830 --> 00:22:25,510 +Activation للجاك وطبعا هذه عبارة عن Energy Process + +256 +00:22:25,510 --> 00:22:31,410 +Energy-Demand Process بيصير فيه ATP فقدان للـATP + +257 +00:22:31,410 --> 00:22:36,370 +وفي نفس الوقت بيصير فيه Phosphorylation للجاك شو + +258 +00:22:36,370 --> 00:22:40,590 +بيعمل الجاك؟ بيجيب الجاك بنشط بروتين تاني او + +259 +00:22:40,590 --> 00:22:46,530 +Transcriptional Factor تاني هو الستات ماشي Single + +260 +00:22:46,530 --> 00:22:53,850 +TransTranscription and Translation Protein هذا هو + +261 +00:22:53,850 --> 00:22:58,670 +الستاد اختصارا single Transcription and + +262 +00:22:58,670 --> 00:23:04,410 +Translation Protein ايه حصل لفسوفراليشن طبعا اتما + +263 +00:23:04,410 --> 00:23:08,150 +صار فيه الفسوفراليشن بيصل له Diamerizationوالاستاذ + +264 +00:23:08,150 --> 00:23:12,550 +اذا حصلت ديماريزيشن يدخل الداخل النيوكلياس وهناك + +265 +00:23:12,550 --> 00:23:17,430 +برتبط في الجينات المطلوب منها transcription و + +266 +00:23:17,430 --> 00:23:21,970 +translation عشان تنتجلي action تنتجلي protein صاحب + +267 +00:23:21,970 --> 00:23:27,790 +اي وظيفةهذا مثال حقيقي على الـ Signal Transduction + +268 +00:23:27,790 --> 00:23:32,630 +وزي ما انتوا شايفين اي ستات و جاك كل واحد له + +269 +00:23:32,630 --> 00:23:37,770 +وظيفته وكل واحد بنشط certain stat و certain jack + +270 +00:23:37,770 --> 00:23:42,410 +can only incorporate on their action at the same + +271 +00:23:42,410 --> 00:23:44,770 +time ف jack واحد هان في الغامض انا انا انا انا انا + +272 +00:23:44,770 --> 00:23:46,030 +انا انا انا انا انا انا انا انا انا انا انا انا + +273 +00:23:46,030 --> 00:23:48,010 +انا انا انا انا انا انا انا انا انا انا انا انا + +274 +00:23:48,010 --> 00:23:48,950 +انا انا انا انا انا انا انا انا انا انا انا انا + +275 +00:23:48,950 --> 00:23:49,150 +انا انا انا انا انا انا انا انا انا انا انا انا + +276 +00:23:49,150 --> 00:23:54,120 +انا انا انا انا انا انا انا انا انا اناالف وبيتا + +277 +00:23:54,120 --> 00:24:01,400 +انتفارون جاك واحد انتاروزين كنيز اتنين بنشت استات + +278 +00:24:01,400 --> 00:24:07,440 +ايلتوا جاك واحد وجاك تلاتة بنشت استات فاف + +279 +00:24:11,600 --> 00:24:17,280 +العضلات الفيرالية ممكن تتعامل مع الـ cytokine و + +280 +00:24:17,280 --> 00:24:22,140 +الهيئة الهيئة الهيئة الهيئة الهيئة الهيئة الهيئة + +281 +00:24:22,140 --> 00:24:27,260 +الهيئة الهيئة الهيئة + +282 +00:24:30,920 --> 00:24:38,680 +البرود بيفرز او ماكسوما فيروس بيفرز سوليو الجاما + +283 +00:24:38,680 --> 00:24:46,180 +انترفيرون ريسبتور وهذا can bind الجاما انترفيرون + +284 +00:24:46,180 --> 00:24:51,400 +ريسبتور وبالتالي بعمل blocking لل action of + +285 +00:24:51,400 --> 00:24:54,160 +cytokine والفيروس بي + +286 +00:24:56,820 --> 00:25:04,020 +نعنش يعني يوم تتنشط تير برا واحد تير برا اتنين يوم + +287 +00:25:04,020 --> 00:25:07,900 +تتنشط تير برا واحد تير برا اتنين زي ما قلنا عيالته + +288 +00:25:07,900 --> 00:25:11,640 +جامعة interferon human cross factor GM CSF + +289 +00:25:14,660 --> 00:25:20,980 +لكن تي البرتوب تحتاج ل I L 4 I L 5 I L 10 I L 13 + +290 +00:25:20,980 --> 00:25:26,560 +طبعا هذه تنشط ميكروفيرد وهذه تنشط ميليم فور سايتس + +291 +00:25:28,940 --> 00:25:33,880 +وهي ال regulation كيف بتتم هي Macrophage ارتبطة + +292 +00:25:33,880 --> 00:25:43,420 +تبنيه تي CD4T-Helper Cell ماشي هي تفرز IL-2 بتنشط + +293 +00:25:43,420 --> 00:25:52,700 +ال ash نفسها و في نفس الوقت تبدأ تتنشطاللي هو أوطن + +294 +00:25:52,700 --> 00:25:59,120 +.. يعني ت .. سلة differentiation اما الاتيه البر + +295 +00:25:59,120 --> 00:26:01,940 +واحد او الاتيه البر اتنينطب كده في هذا الكلام + +296 +00:26:01,940 --> 00:26:05,700 +قالوا إذا فرضت I L 12 تشت تيهيلبر واحد وفي نفس + +297 +00:26:05,700 --> 00:26:11,300 +الوقت تيهيلبر واحد تطلع النجامة interferon اللي + +298 +00:26:11,300 --> 00:26:16,320 +بيعمل inhibition لذراع تيهيلبر 2 ونفس الحكاية إذا + +299 +00:26:16,320 --> 00:26:22,500 +I L 4 طلع نشط تيهيلبر 2 اللي بتطلع I L 4 و I L 5 و + +300 +00:26:22,500 --> 00:26:27,780 +I L 10 ماشي ال cytokine هذه و إذا فرضت I L 10 لعمل + +301 +00:26:27,780 --> 00:26:31,610 +inhibition لمين؟لذراعته المرتوى + +302 +00:26:34,200 --> 00:26:38,420 +وهذا نفس الحكاية بس على مستوى transcriptional + +303 +00:26:38,420 --> 00:26:48,160 +factor I L 4 نشط Stat 6 نشط لي Gata 3 اللي عملت + +304 +00:26:48,160 --> 00:26:56,640 +inhibition لتيبة ماشي وبالتالي هذا هي نشطة I L 4 + +305 +00:26:56,640 --> 00:27:00,500 +على I L 5 وفي نفس الوقت عملت inhibition لجامعة + +306 +00:27:00,500 --> 00:27:07,090 +الفيرورفبالتالي طلع هذا كله و جف و مين اتنشطت + +307 +00:27:07,090 --> 00:27:11,910 +تيهيلبرتو نفس الحكاية يوم يكون في gamma interferon + +308 +00:27:11,910 --> 00:27:19,350 +طالع من الخلية ستة واحد مش ستة احد اتنشط اللي بنشط + +309 +00:27:19,350 --> 00:27:22,910 +ليه transcription factor اسمه TBET اللي بيعمل + +310 +00:27:22,910 --> 00:27:26,330 +inhibition ل GATA3 و في نفس الوقت بيعمل inhibition + +311 +00:27:26,330 --> 00:27:31,710 +ل IL4 على IL5 و بنشط ال gamma interferon فبتطلع ان + +312 +00:27:32,260 --> 00:27:39,240 +الـ T helper واحد منشطة كمان + +313 +00:27:39,240 --> 00:27:44,120 +لازم نذكر الـ T helper 17 و T reg cells التنتين + +314 +00:27:44,120 --> 00:27:52,020 +بالمناسبة CD4 T cell + +315 +00:27:52,020 --> 00:27:58,180 +بس واحدة Fox B positive و واحدة Fox B negative فما + +316 +00:27:58,180 --> 00:28:05,920 +تنتين CD4 ماشيهذه الوظيفة تعتبر الـ T-Helper 17 + +317 +00:28:05,920 --> 00:28:13,620 +لأنها تفرز الـ IL-17 تعتبر الـ T-Helper 17 تعتبر + +318 +00:28:13,620 --> 00:28:18,880 +الـ IL-17 تعتبر الـ IL-17بتطلع لنا IL-17 وهو + +319 +00:28:18,880 --> 00:28:22,560 +عدبارة عن الـ Pro-inflammatory cytokine وظيفته + +320 +00:28:22,560 --> 00:28:29,260 +الأساسية انه ينشط اللي هو يطلع لنا Pro + +321 +00:28:29,260 --> 00:28:33,040 +-inflammatory cytokine زي IL-6 بتطلعه من ال + +322 +00:28:33,040 --> 00:28:38,820 +fibroblasts و ال endothelial cells وبيعتبر ال + +323 +00:28:38,820 --> 00:28:42,900 +telbar cells بتعتبر ك critical antibacterial + +324 +00:28:42,900 --> 00:28:48,810 +immunityليش؟ وبالذات هاه وبالذات it's associated + +325 +00:28:48,810 --> 00:28:52,050 +with rheumatoid arthritis بقى دي ال autoimmune + +326 +00:28:52,050 --> 00:28:56,950 +disease و ال SLE و myasthenia multiple sclerosis و + +327 +00:28:56,950 --> 00:29:04,550 +أزمة ال IL-17 ماشي و يعتبر pro-inflammatory يعني + +328 +00:29:04,550 --> 00:29:10,210 +بيعمل inflammation تيريج هي برنامج CD4 positive و + +329 +00:29:10,210 --> 00:29:17,470 +FOXP3 positiveغالبا تتكوّن في الـ Thymus وتعمل + +330 +00:29:17,470 --> 00:29:20,730 +انهيبشين لـ effector T cell development في الـ + +331 +00:29:20,730 --> 00:29:27,230 +lymph nodes و أيضا تتنش induced in periphery و + +332 +00:29:27,230 --> 00:29:30,010 +تتنش developed in periphery و تتنش developed under + +333 +00:29:30,010 --> 00:29:33,250 +the influence of transformed growth factor beta + +334 +00:29:33,250 --> 00:29:35,490 +تتنش انهيبش انهيبش انهيبش انهيبش انهيبش انهيبش + +335 +00:29:35,490 --> 00:29:36,310 +انهيبش انهيبش انهيبش انهيبش انهيبش انهيبش انهيبش + +336 +00:29:36,310 --> 00:29:39,550 +انهيبش انهيبش انهيبش انهيبش انهيبش انهيبش انهيبش + +337 +00:29:41,540 --> 00:29:49,400 +هذه نفس الحكاية تي هيلبردفرانشيشن تيهيلبردوالف + +338 +00:29:49,400 --> 00:29:51,680 +تيهيلبردوالف تيهيلبردوالف تيهيلبردوالف + +339 +00:29:51,680 --> 00:29:53,280 +تيهيلبردوالف تيهيلبردوالف تيهيلبردوالف + +340 +00:29:53,280 --> 00:29:54,700 +تيهيلبردوالف تيهيلبردوالف تيهيلبردوالف + +341 +00:29:54,700 --> 00:29:56,800 +تيهيلبردوالف تيهيلبردوالف تيهيلبردوالف + +342 +00:29:56,800 --> 00:30:02,760 +تيهيلبردوالف تيهيلبردوالف تيهيلبردوالف + +343 +00:30:02,760 --> 00:30:08,400 +تيهيلبردوالف تيهيلبردوالف تيهيلبردوالف + +344 +00:30:08,400 --> 00:30:11,180 +تيهيلبردوالف تيهيلبردوالف تيهيلبردوالف تيهيلبرعمل + +345 +00:30:11,180 --> 00:30:16,580 +انهيبش اللي فوق في نفس الوقت صار فيها نتيجة + +346 +00:30:16,580 --> 00:30:26,100 +البرتوق activity aisle 23 aisle 2 بنشت اللي هو ال + +347 +00:30:27,830 --> 00:30:33,610 +التي هي البرسيل اللي هي بتطلع انها IL-17 وهذا + +348 +00:30:33,610 --> 00:30:39,170 +عبارة عن اللي هو Pro-inflammatory-cytokine بتطلع + +349 +00:30:39,170 --> 00:30:45,410 +من الخلايا هذه Regulation of cytokine جاله اما باي + +350 +00:30:45,410 --> 00:30:51,640 +كرماتين Structureتوقف ال expression of the + +351 +00:30:51,640 --> 00:30:55,360 +chromatin structure و ال cytokine therapy احنا + +352 +00:30:55,360 --> 00:30:59,360 +ممكن نستخدمها في ال therapy ببساطة by using + +353 +00:30:59,360 --> 00:31:03,180 +antibody that + +354 +00:31:03,180 --> 00:31:08,040 +block the receptor وبالتالي بتعمل inhibition لل + +355 +00:31:08,040 --> 00:31:12,080 +action of IL-2 يعني يطلع ال action of IL-2 لكن + +356 +00:31:12,080 --> 00:31:15,180 +احنا استخدمنا antibody that block the receptor of + +357 +00:31:15,180 --> 00:31:19,790 +IL-2 وبالتالي بطل يشتغلالـ IL-2 وبالتالي هذا مفيد + +358 +00:31:19,790 --> 00:31:24,510 +في حالات ال autoimmune disease على سبيل المثال لما + +359 +00:31:24,510 --> 00:31:32,870 +بيتوقف ال immune response ايضا ممكن استخدم IL-2 + +360 +00:31:32,870 --> 00:31:38,640 +analogبينافس الـ IL-2 في الارتباط بالرسيبتور + +361 +00:31:38,640 --> 00:31:43,200 +وبالتالي إذا ارتبط ال IL-2 لما يجي مش راح يلاقي + +362 +00:31:43,200 --> 00:31:49,380 +الرسيبتور مشغول و برضه مش راح يشتغل Destruction of + +363 +00:31:49,380 --> 00:31:56,550 +activated T-Liposyl ببساطة احنا ممكنان مربط تكسين + +364 +00:31:56,550 --> 00:32:02,130 +الـ cytokine بيتوكسين وبالتالي اول ما يرتبط + +365 +00:32:02,130 --> 00:32:06,530 +بالرسيبتور اللى على سطح الـ T-Helper cell بعمل + +366 +00:32:06,530 --> 00:32:14,210 +destruction للخلية نفسها ودى قائمة بانواع ال + +367 +00:32:14,210 --> 00:32:22,580 +cytokine اللى بتستخدم in clinical useوبهيك اتمنى + +368 +00:32:22,580 --> 00:32:31,740 +ان اكون غطيت المحاضرة مع تمانياتيلكم بالإيش بالفهم + +369 +00:32:31,740 --> 00:32:32,200 +الجيد + diff --git a/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/s4m5oI817q8_raw.json b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/s4m5oI817q8_raw.json new file mode 100644 index 0000000000000000000000000000000000000000..486c0dea6c5981506f7dcb1e69809206d04f8158 --- /dev/null +++ b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/s4m5oI817q8_raw.json @@ -0,0 +1 @@ +{"segments": [{"id": 1, "seek": 2772, "start": 2.06, "end": 27.72, "text": "بسم الله الرحمن الرحيم حضرتنا اليوم ان شاء الله عن ال cytokine و cytokine تعريفا هي برهان مجموعة من ال chemical messenger وظائفها نمر واحد مدية and regulate the immune system و بتعمل regulation لل immune system", "tokens": [3555, 38251, 21984, 34892, 5016, 27842, 34892, 5016, 32640, 11331, 11242, 43500, 8315, 45595, 20498, 16472, 13412, 16606, 21984, 18871, 2423, 40248, 453, 533, 4032, 40248, 453, 533, 37279, 16572, 5172, 995, 39896, 4724, 2288, 3224, 7649, 3714, 7435, 2304, 2407, 27884, 9154, 2423, 7313, 26599, 4032, 19913, 16373, 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1.0}, {"id": 56, "seek": 138679, "start": 1368.29, "end": 1386.79, "text": "Transcription and Translation Protein هذا هو الستاد اختصارا single Transcription and Translation Protein ايه حصل لفسوفراليشن طبعا اتما صار فيه الفسوفراليشن بيصل له Diamerization", "tokens": [33339, 12432, 293, 6531, 24278, 43371, 259, 23758, 31439, 2423, 14851, 18513, 1975, 46456, 9381, 9640, 995, 2167, 6531, 12432, 293, 6531, 24278, 43371, 259, 1975, 1829, 3224, 11331, 36520, 5296, 5172, 3794, 38688, 2288, 6027, 1829, 8592, 1863, 23032, 3555, 3615, 995, 1975, 2655, 15042, 20328, 9640, 8978, 3224, 27188, 3794, 38688, 2288, 6027, 1829, 8592, 1863, 4724, 1829, 36520, 46740, 21706, 260, 2144], "avg_logprob": -0.5222537842663851, "compression_ratio": 1.5541401273885351, "no_speech_prob": 2.980232238769531e-07, "words": [{"start": 1368.29, "end": 1368.83, "word": "Transcription", "probability": 0.453125}, {"start": 1368.83, "end": 1369.29, "word": " and", "probability": 0.79150390625}, {"start": 1369.29, "end": 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حصلت ديماريزيشن يدخل الداخل النيوكلياس وهناك برتبط في الجينات المطلوب منها transcription و translation عشان تنتجلي action تنتجلي protein صاحب اي وظيفة", "tokens": [2407, 6027, 995, 14851, 45636, 1975, 15730, 11331, 36520, 2655, 11778, 32640, 9640, 1829, 11622, 1829, 8592, 1863, 7251, 3215, 9778, 1211, 32748, 47283, 1211, 28239, 1829, 2407, 4117, 20292, 32277, 37037, 8315, 4117, 4724, 43500, 3555, 9566, 8978, 25724, 1829, 8315, 2655, 9673, 9566, 1211, 37746, 9154, 11296, 35288, 4032, 12853, 6225, 8592, 7649, 6055, 29399, 7435, 20292, 3069, 6055, 29399, 7435, 20292, 7944, 20328, 39319, 3555, 1975, 1829, 4032, 19913, 33911, 3660], "avg_logprob": -0.38687500556310017, "compression_ratio": 1.5113636363636365, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 1387.29, "end": 1388.15, "word": "والاستاذ", "probability": 0.4555419921875}, {"start": 1388.15, "end": 1388.93, "word": " اذا", "probability": 0.6617431640625}, {"start": 1388.93, "end": 1389.29, "word": " حصلت", 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"word": " بيحصل", "probability": 0.629150390625}, {"start": 369.18, "end": 369.32, "word": " في", "probability": 0.94482421875}, {"start": 369.32, "end": 369.52, "word": " الـ", "probability": 0.52392578125}, {"start": 369.52, "end": 369.94, "word": " Serum", "probability": 0.759765625}, {"start": 369.94, "end": 371.02, "word": " عشان", "probability": 0.908203125}, {"start": 371.02, "end": 371.48, "word": " يعمل", "probability": 0.9754231770833334}, {"start": 371.48, "end": 372.18, "word": " Lyses", "probability": 0.5672200520833334}, {"start": 372.18, "end": 373.3, "word": " لخمسين", "probability": 0.851611328125}, {"start": 373.3, "end": 373.46, "word": " في", "probability": 0.388916015625}, {"start": 373.46, "end": 373.98, "word": " المية", "probability": 0.7490234375}, {"start": 373.98, "end": 375.0, "word": " من", "probability": 0.982421875}, {"start": 375.0, "end": 375.92, "word": " محلول", "probability": 0.906982421875}, {"start": 375.92, "end": 376.56, "word": " في", 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{"start": 558.17, "end": 558.53, "word": " micro", "probability": 0.96875}, {"start": 558.53, "end": 559.23, "word": " environment", "probability": 0.8671875}, {"start": 559.23, "end": 561.75, "word": " الجزء", "probability": 0.97802734375}, {"start": 561.75, "end": 562.45, "word": " الكبير", "probability": 0.9798177083333334}, {"start": 562.45, "end": 562.79, "word": " اللي", "probability": 0.955078125}, {"start": 562.79, "end": 563.17, "word": " هو", "probability": 0.99462890625}, {"start": 563.17, "end": 563.79, "word": " بيناطله", "probability": 0.57451171875}, {"start": 563.79, "end": 564.21, "word": " letter", "probability": 0.6015625}, {"start": 564.21, "end": 564.41, "word": " ..", "probability": 0.5107421875}, {"start": 564.41, "end": 564.97, "word": " بيناطله", "probability": 0.90244140625}, {"start": 564.97, "end": 565.23, "word": " letter", "probability": 0.955078125}, {"start": 565.23, "end": 565.55, "word": " B", "probability": 0.453125}, {"start": 565.55, "end": 565.81, "word": " يعني", "probability": 0.95166015625}], "temperature": 1.0}, {"id": 22, "seek": 58937, "start": 566.63, "end": 589.37, "text": "ندّي رمز B والـ A بنعطله الصغير وهذه القاعدة تنطبق على كل complement component ما عدا C2 C2 الكبير بياخد رمز A والصغير بياخد رمز B", "tokens": [1863, 3215, 11703, 1829, 12602, 2304, 11622, 363, 16070, 39184, 316, 44945, 3615, 9566, 43761, 31767, 17082, 13546, 37037, 24192, 25062, 995, 22488, 3660, 6055, 1863, 9566, 3555, 4587, 15844, 28242, 17103, 6542, 19446, 6225, 28259, 383, 17, 383, 17, 33251, 3555, 13546, 4724, 1829, 47283, 3215, 12602, 2304, 11622, 316, 16070, 9381, 17082, 13546, 4724, 1829, 47283, 3215, 12602, 2304, 11622, 363], "avg_logprob": -0.29174804873764515, "compression_ratio": 1.4444444444444444, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 566.63, "end": 567.49, "word": "ندّي", "probability": 0.49273681640625}, {"start": 567.49, "end": 570.77, "word": " رمز", "probability": 0.9768880208333334}, {"start": 570.77, "end": 571.03, "word": " B", "probability": 0.50146484375}, {"start": 571.03, "end": 574.25, "word": " والـ", "probability": 0.450927734375}, {"start": 574.25, "end": 575.01, "word": " A", "probability": 0.65283203125}, {"start": 575.01, "end": 575.65, "word": " بنعطله", "probability": 0.49761962890625}, {"start": 575.65, "end": 576.21, "word": " الصغير", "probability": 0.8048502604166666}, {"start": 576.21, "end": 578.81, "word": " وهذه", "probability": 0.765869140625}, {"start": 578.81, "end": 579.27, "word": " القاعدة", "probability": 0.9874267578125}, {"start": 579.27, "end": 579.69, "word": " تنطبق", "probability": 0.92744140625}, {"start": 579.69, "end": 579.83, "word": " على", "probability": 0.91748046875}, {"start": 579.83, "end": 580.27, "word": " كل", "probability": 0.9482421875}, {"start": 580.27, "end": 580.83, "word": " complement", "probability": 0.2144775390625}, {"start": 580.83, "end": 581.77, "word": " component", "probability": 0.9677734375}, {"start": 581.77, "end": 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592.34, "end": 615.5, "text": "طب نيجي نتطرق لل complement pathways وقالوا فيه تلاتة pathways فيه ال classical pathway وفيه ال lectin pathway وفيه ال alternative pathway ال classical pathway عشان يتنشط لابد من وجود antibody .. antigen antibody reaction يعني antibody dependent", "tokens": [9566, 3555, 8717, 1829, 7435, 1829, 8717, 2655, 9566, 2288, 4587, 24976, 17103, 22988, 4032, 4587, 6027, 14407, 8978, 3224, 6055, 1211, 9307, 3660, 22988, 8978, 3224, 2423, 13735, 18590, 4032, 41185, 3224, 2423, 5899, 259, 18590, 4032, 41185, 3224, 2423, 8535, 18590, 2423, 13735, 18590, 6225, 8592, 7649, 7251, 2655, 1863, 8592, 9566, 5296, 16758, 3215, 9154, 49610, 23328, 34507, 4386, 2511, 3213, 34507, 5480, 37495, 22653, 34507, 12334], "avg_logprob": -0.2012543946924344, "compression_ratio": 1.6881720430107527, "no_speech_prob": 2.980232238769531e-07, "words": [{"start": 592.34, "end": 592.72, "word": "طب", "probability": 0.4207763671875}, {"start": 592.72, "end": 593.06, "word": " نيجي", 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1349.82, "end": 1350.58, "word": " بي", "probability": 0.96826171875}, {"start": 1350.58, "end": 1352.02, "word": " و", "probability": 0.7744140625}, {"start": 1352.02, "end": 1352.48, "word": " يهدى", "probability": 0.79296875}, {"start": 1352.48, "end": 1353.0, "word": " نفسه", "probability": 0.9972330729166666}, {"start": 1353.0, "end": 1354.08, "word": " بالدينة", "probability": 0.78173828125}, {"start": 1354.08, "end": 1354.46, "word": " تلاتة", "probability": 0.9599609375}, {"start": 1354.46, "end": 1354.8, "word": " بي", "probability": 0.956298828125}, {"start": 1354.8, "end": 1356.02, "word": " اللي", "probability": 0.96337890625}, {"start": 1356.02, "end": 1356.56, "word": " هيمسك", "probability": 0.9085693359375}, {"start": 1356.56, "end": 1356.86, "word": " في", "probability": 0.9833984375}, {"start": 1356.86, "end": 1357.66, "word": " ال", "probability": 0.68408203125}, {"start": 1357.66, "end": 1357.84, "word": " B", "probability": 0.409912109375}, {"start": 1357.84, "end": 1358.48, "word": "-protein", "probability": 0.9549560546875}, {"start": 1358.48, "end": 1359.68, "word": " وينقطع", "probability": 0.9368896484375}], "temperature": 1.0}, {"id": 54, "seek": 138275, "start": 1360.33, "end": 1382.75, "text": "و يتكون تلاتة BB و هيشتلها تلاتة و يقطعها على تلاتة B و تلاتة A و تحت انفصل تلاتة B ترتبط ب ب بروتين و ينقطع و يكون BB", "tokens": [2407, 7251, 2655, 30544, 6055, 1211, 9307, 3660, 19168, 4032, 39896, 8592, 2655, 1211, 11296, 6055, 1211, 9307, 3660, 4032, 7251, 47432, 3615, 11296, 15844, 6055, 1211, 9307, 3660, 363, 4032, 6055, 1211, 9307, 3660, 316, 4032, 6055, 33753, 16472, 5172, 36520, 6055, 1211, 9307, 3660, 363, 6055, 43500, 3555, 9566, 4724, 4724, 4724, 32887, 2655, 9957, 4032, 7251, 1863, 47432, 3615, 4032, 7251, 30544, 19168], "avg_logprob": -0.2663246224175638, "compression_ratio": 1.7787610619469028, "no_speech_prob": 1.049041748046875e-05, "words": [{"start": 1360.33, "end": 1360.85, "word": "و", "probability": 0.70263671875}, 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{"start": 1372.09, "end": 1372.47, "word": " تلاتة", "probability": 0.9837646484375}, {"start": 1372.47, "end": 1372.89, "word": " A", "probability": 0.98828125}, {"start": 1372.89, "end": 1374.81, "word": " و", "probability": 0.6171875}, {"start": 1374.81, "end": 1375.09, "word": " تحت", "probability": 0.4537353515625}, {"start": 1375.09, "end": 1375.61, "word": " انفصل", "probability": 0.748046875}, {"start": 1375.61, "end": 1376.09, "word": " تلاتة", "probability": 0.9849853515625}, {"start": 1376.09, "end": 1376.39, "word": " B", "probability": 0.90673828125}, {"start": 1376.39, "end": 1377.73, "word": " ترتبط", "probability": 0.858154296875}, {"start": 1377.73, "end": 1377.97, "word": " ب", "probability": 0.267333984375}, {"start": 1377.97, "end": 1378.25, "word": " ب", "probability": 0.5439453125}, {"start": 1378.25, "end": 1379.11, "word": " بروتين", "probability": 0.71112060546875}, {"start": 1379.11, "end": 1380.07, "word": " و", "probability": 0.97216796875}, {"start": 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"text": "كان يصل لها degradation طيب لو الـ C3P اتنشطت على سطح abnormal cell membrane شو اللي بيصير؟ جاله في حاجة اسمها protector membrane أو abnormal cell membrane ده هو شايفين كان بتثبت الموليكولة C3P بيمسك في الـ B و الـ B جيه D بيقطعوا", "tokens": [41361, 7251, 36520, 5296, 11296, 40519, 23032, 1829, 3555, 45164, 2423, 39184, 383, 18, 47, 1975, 2655, 1863, 8592, 9566, 2655, 15844, 8608, 9566, 5016, 32847, 2815, 19651, 13412, 2407, 13672, 1829, 4724, 1829, 9381, 13546, 22807, 10874, 6027, 3224, 8978, 11331, 26108, 3660, 24525, 2304, 11296, 34986, 19651, 34051, 32847, 2815, 19651, 11778, 3224, 31439, 13412, 995, 33911, 9957, 25961, 39894, 12984, 3555, 2655, 9673, 12610, 1829, 4117, 12610, 3660, 383, 18, 47, 4724, 32640, 3794, 4117, 8978, 2423, 39184, 363, 4032, 2423, 39184, 363, 10874, 1829, 3224, 413, 4724, 1829, 47432, 3615, 14407], "avg_logprob": -0.2661132688323657, "compression_ratio": 1.5178571428571428, "no_speech_prob": 2.47955322265625e-05, "words": [{"start": 1689.19, 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في", "probability": 0.83154296875}, {"start": 2106.47, "end": 2107.81, "word": " أنافلاكسيه", "probability": 0.93115234375}, {"start": 2107.81, "end": 2108.25, "word": " ال", "probability": 0.7568359375}, {"start": 2108.25, "end": 2108.99, "word": " regulators", "probability": 0.5654296875}, {"start": 2108.99, "end": 2110.35, "word": " كربوكسي", "probability": 0.75457763671875}, {"start": 2110.35, "end": 2111.13, "word": " بيبتايديز", "probability": 0.82843017578125}, {"start": 2111.13, "end": 2111.61, "word": " بي", "probability": 0.702392578125}, {"start": 2111.61, "end": 2116.09, "word": " وC3B", "probability": 0.6937255859375}], "temperature": 1.0}, {"id": 84, "seek": 214679, "start": 2117.81, "end": 2146.79, "text": "بساعد الـ phagocytic activation و ال regulator HY C4A أنفلاتوكسين بيأز C3 بي .. C3 سري but less potent و ال inhibitor هو C3 inhibitor C4B-obsolene بعمل obsolization و phagocytosis و C4B بي .. binding بروتين يعني و factor I", "tokens": [3555, 3794, 995, 22488, 2423, 39184, 903, 6442, 1344, 40907, 24433, 4032, 2423, 36250, 34189, 383, 19, 32, 14739, 5172, 15040, 2655, 2407, 4117, 3794, 9957, 4724, 1829, 10721, 11622, 383, 18, 4724, 1829, 4386, 383, 18, 8608, 16572, 457, 1570, 27073, 4032, 2423, 20406, 3029, 31439, 383, 18, 20406, 3029, 383, 19, 33, 12, 16537, 401, 1450, 4724, 25957, 1211, 3181, 401, 2144, 4032, 903, 6442, 1344, 83, 8211, 4032, 383, 19, 33, 4724, 1829, 4386, 17359, 4724, 32887, 2655, 9957, 37495, 22653, 4032, 5952, 286], "avg_logprob": -0.41583807089112024, "compression_ratio": 1.3645320197044335, "no_speech_prob": 3.814697265625e-06, "words": [{"start": 2117.81, "end": 2118.25, "word": "بساعد", "probability": 0.84259033203125}, {"start": 2118.25, "end": 2118.41, "word": " الـ", "probability": 0.510009765625}, {"start": 2118.41, "end": 2119.03, "word": " phagocytic", "probability": 0.63409423828125}, {"start": 2119.03, "end": 2119.87, "word": " activation", "probability": 0.9775390625}, {"start": 2119.87, "end": 2121.35, "word": " و", "probability": 0.4970703125}, {"start": 2121.35, "end": 2121.49, "word": " ال", "probability": 0.50048828125}, {"start": 2121.49, "end": 2121.83, "word": " regulator", "probability": 0.59130859375}, {"start": 2121.83, "end": 2122.59, "word": " HY", "probability": 0.46728515625}, {"start": 2122.59, "end": 2125.29, "word": " C4A", "probability": 0.7278645833333334}, {"start": 2125.29, "end": 2126.65, "word": " أنفلاتوكسين", "probability": 0.6669921875}, {"start": 2126.65, "end": 2127.73, "word": " بيأز", "probability": 0.5460205078125}, {"start": 2127.73, "end": 2128.27, "word": " C3", "probability": 0.880859375}, {"start": 2128.27, "end": 2129.83, "word": " بي", "probability": 0.611328125}, {"start": 2129.83, "end": 2130.13, "word": " ..", "probability": 0.2491455078125}, {"start": 2130.13, "end": 2130.83, "word": " C3", "probability": 0.681884765625}, {"start": 2130.83, "end": 2131.17, "word": " سري", "probability": 0.2696533203125}, {"start": 2131.17, "end": 2131.65, "word": " but", "probability": 0.231689453125}, {"start": 2131.65, "end": 2131.93, "word": " less", "probability": 0.9189453125}, {"start": 2131.93, "end": 2132.43, "word": " potent", "probability": 0.9755859375}, {"start": 2132.43, "end": 2133.55, "word": " و", "probability": 0.81640625}, {"start": 2133.55, "end": 2133.87, "word": " ال", "probability": 0.955078125}, {"start": 2133.87, "end": 2134.57, "word": " inhibitor", "probability": 0.88623046875}, {"start": 2134.57, "end": 2134.99, "word": " هو", "probability": 0.92431640625}, {"start": 2134.99, "end": 2135.65, "word": " C3", "probability": 0.965576171875}, {"start": 2135.65, "end": 2137.39, "word": " inhibitor", "probability": 0.88037109375}, {"start": 2137.39, "end": 2139.01, "word": " C4B", "probability": 0.9353841145833334}, {"start": 2139.01, 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الـ cell membrane والجرانزايم دخل من خلال الـ channel وبالتالي قتل الخلية steps of in cytotoxic killing كان الخطوات بالتمكالات نمرا واحد ال T cytotoxic تتعرف على target cell المصابة ثم بتعمل", "tokens": [10721, 1829, 2423, 26890, 5172, 2288, 1863, 6225, 42213, 1975, 1829, 3224, 22807, 6225, 42213, 2423, 39184, 2269, 8978, 2423, 39184, 2815, 19651, 16070, 7435, 2288, 7649, 11622, 995, 32640, 11778, 9778, 1211, 9154, 16490, 1211, 6027, 2423, 39184, 2269, 46599, 6027, 2655, 6027, 1829, 12174, 2655, 1211, 33962, 1211, 10632, 4439, 295, 294, 40248, 310, 5230, 299, 8011, 25961, 33962, 9566, 2407, 9307, 20666, 39237, 4117, 6027, 9307, 8717, 2304, 23557, 36764, 24401, 2423, 314, 40248, 310, 5230, 299, 6055, 2655, 3615, 28480, 15844, 3779, 2815, 9673, 9381, 16758, 3660, 38637, 2304, 39894, 25957, 1211], "avg_logprob": -0.4027061757353163, "compression_ratio": 1.5605381165919283, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1016.28, "end": 1016.58, "word": "أي", "probability": 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بتبط في مين بيبقى فالت من ال antibody", "tokens": [3224, 2407, 7251, 2655, 9381, 3215, 1211, 14407, 34507, 9154, 3224, 26367, 38, 28242, 8315, 44945, 3615, 28480, 16472, 2423, 26367, 38, 31439, 6225, 3555, 9640, 3660, 18871, 3181, 259, 533, 19446, 4724, 1829, 28543, 2288, 7251, 38149, 1211, 2423, 2511, 3213, 4032, 7649, 15042, 4724, 1829, 30241, 2304, 14407, 9122, 33911, 4724, 1829, 30241, 2304, 14407, 4724, 2655, 3555, 9566, 8978, 3714, 9957, 4724, 1829, 3555, 4587, 7578, 6156, 6027, 2655, 9154, 2423, 34507], "avg_logprob": -0.2997532977085364, "compression_ratio": 1.509090909090909, "no_speech_prob": 7.748603820800781e-07, "words": [{"start": 1323.08, "end": 1323.32, "word": "هو", "probability": 0.420867919921875}, {"start": 1323.32, "end": 1324.16, "word": " يتصدلوا", "probability": 0.73193359375}, {"start": 1324.16, "end": 1324.62, "word": " antibody", "probability": 0.19921875}, {"start": 1324.62, "end": 1325.12, "word": " منه", "probability": 0.8876953125}, {"start": 1325.12, 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+تيهيلبر او تيهيلبر او تيهيلبر او تيهيلبر او + +7 +00:00:24,000 --> 00:00:24,180 +تيهيلبر او تيهيلبر او تيهيلبر او تيهيلبر او + +8 +00:00:24,180 --> 00:00:24,460 +تيهيلبر او تيهيلبر او تيهيلبر او تيهيلبر او + +9 +00:00:24,460 --> 00:00:28,400 +تيهيلبر او تيهيلبر او تيهيلبر او تيهيلبر + +10 +00:00:29,730 --> 00:00:33,870 +وسنتطلق في النهاية للـ Immunoregulatory Mechanisms + +11 +00:00:33,870 --> 00:00:38,610 +كنت + +12 +00:00:38,610 --> 00:00:43,950 +قرر افتيه لبرسيل ان specific immunity جالوه هي + +13 +00:00:43,950 --> 00:00:48,530 +عبارة عن الخلية الأساسية اللى بتلعب دور كبير اللى + +14 +00:00:48,530 --> 00:00:54,430 +can play an orchestrate role يعني هي select the + +15 +00:00:54,430 --> 00:00:59,770 +effector mechanism يعني بنجوسين هي من توزعأدوار + +16 +00:00:59,770 --> 00:01:05,310 +الخلايا في الـ immune response الامر اتنين induce + +17 +00:01:05,310 --> 00:01:09,090 +proliferation inappropriate effector يوم ما تنشط + +18 +00:01:09,090 --> 00:01:14,230 +خلية معينة بتعملها induction لل proliferation عشان + +19 +00:01:14,230 --> 00:01:20,700 +تنقسم الى effector cell و memory cellثم enhanced + +20 +00:01:20,700 --> 00:01:24,040 +functional activity of a vector cell بتحدث خط + +21 +00:01:24,040 --> 00:01:29,920 +صيرها للخلية النشطة وهذه صورة أو figure بيمثلي + +22 +00:01:29,920 --> 00:01:34,300 +الكلام اللي بنحكيه انتجن presenting cell أخدت + +23 +00:01:34,300 --> 00:01:40,780 +الانتجن قدمته لتيه البرسيلتبتدى البرسيل ده نشطة + +24 +00:01:40,780 --> 00:01:45,440 +اما ت بي سل اللى بده تتكون لانتيبادي او ت + +25 +00:01:45,440 --> 00:01:50,700 +سايتوتكسك لمفوسايتس اللى بتعمل عملية قضاء للخلايا + +26 +00:01:50,700 --> 00:01:58,380 +مباشرة للانترا سيلولار انتجين + +27 +00:01:58,380 --> 00:02:02,920 +اللى موجود فى داخل الخلايا يعنى اما بتعمل همارال + +28 +00:02:02,920 --> 00:02:06,700 +اميونيتي او cell mediated immunity and it also can + +29 +00:02:06,700 --> 00:02:14,530 +reduceوالـ cytokine حسب نوعها ممكن تنشط ميكروفيج + +30 +00:02:14,530 --> 00:02:17,350 +ميكروفيج انكي سيل + +31 +00:02:20,430 --> 00:02:25,050 +هذه الخلايا أيضًا ممكن يطلع منها cytokine زي الـ + +32 +00:02:25,050 --> 00:02:29,170 +macrophage اللي ممكن ينشب other cells زي الـ NK + +33 +00:02:29,170 --> 00:02:34,030 +cell لـ granulocyte وحتى الـ NK cell تعتمد في + +34 +00:02:34,030 --> 00:02:40,390 +تنشيطها بعض مرات على ال antibody اللي بيفرس وبتلي + +35 +00:02:40,390 --> 00:02:45,640 +لها أدوار مختلفةمن اللي عمل هالنخمة دي كلها هي الـ + +36 +00:02:45,640 --> 00:02:49,740 +T-Helpers اللي هي من وزعت الأدوار على الخلايا + +37 +00:02:49,740 --> 00:02:54,620 +المختلفة اتفقنا على ان الخلايا خلية الـ T + +38 +00:02:54,620 --> 00:03:00,020 +-Lymphocyte بتطلع من الـ Thymus كنيف تيسل بيسموها + +39 +00:03:00,020 --> 00:03:04,680 +T-Helper بي يعني Progenitor بمعنى انه لسه لم تصادف + +40 +00:03:04,680 --> 00:03:10,560 +Antigen لكن عندها القدرة على إفراز IL-2على وجه الـ + +41 +00:03:10,560 --> 00:03:18,420 +Presence of Certain Cytokine وAntigen بالطبع يحصل + +42 +00:03:18,420 --> 00:03:22,720 +فيه Short Term Stimulation وبتتحول الخلية هذه إلى + +43 +00:03:22,720 --> 00:03:26,420 +T-Helper Node اللي عندها القدرة أن تفرز كمية أكبر + +44 +00:03:26,420 --> 00:03:31,740 +من الـCytokine وحسب الـCytokine اللي بتفرزه إذا + +45 +00:03:31,740 --> 00:03:38,190 +كان الـCytokine على سبيل المثال IL-12في وجود الـ + +46 +00:03:38,190 --> 00:03:41,750 +IL-12 بيصير فيه Chronic Stimulation وتتحول الخلية + +47 +00:03:41,750 --> 00:03:47,590 +إلى تتخذ خط سيارة جديد وهو T helper-1 وT helper-1 + +48 +00:03:47,590 --> 00:03:52,230 +ماشي تفرس Gamma Interferon وT helper-2 اللي بتنشط + +49 +00:03:52,230 --> 00:03:59,360 +ليه Macrophage بينما في وجود IL-4الخلية تتحول إلى + +50 +00:03:59,360 --> 00:04:04,080 +الـ T-Helper 2-Pathway التي تستطيع أن تفرز كائن في + +51 +00:04:04,080 --> 00:04:08,380 +وجودها الـ cytokine تتحول الخلية أو تنشط الخلية بـ + +52 +00:04:08,380 --> 00:04:13,140 +Lymphocytes وبالتالي تنتج لها Antibody فيا إما + +53 +00:04:13,140 --> 00:04:17,200 +cell mediated immunity يا إما immunal immunity + +54 +00:04:17,200 --> 00:04:24,580 +بحسب T-Helper cell subset اللي تتكونطبعا في كلتا + +55 +00:04:24,580 --> 00:04:27,620 +الحالتين مش ننسى ان الخلية بتسلها proliferation + +56 +00:04:27,620 --> 00:04:30,360 +and differentiation into a vector cell and memory + +57 +00:04:30,360 --> 00:04:35,480 +cell ففي المادة البارقة memory cell ايضا تتكون + +58 +00:04:35,480 --> 00:04:42,230 +upon this stimulationماشي بس الخلية التي اللى هى + +59 +00:04:42,230 --> 00:04:45,570 +تنشطه في آن واحد وجدوا ان الـ T helper one لما + +60 +00:04:45,570 --> 00:04:50,250 +تتنشط او تختار الخلية ال T helper cell تختار ال T + +61 +00:04:50,250 --> 00:04:54,370 +helper one pathway و تفرس gamma interferon وجدوا + +62 +00:04:54,370 --> 00:04:56,830 +ان ال gamma interferon inhibits the proliferation + +63 +00:04:56,830 --> 00:05:02,810 +of T helper twoماشي تي البر وان بتفرز gamma + +64 +00:05:02,810 --> 00:05:06,710 +interferon اللي بينش تتماكرو فيه لكنه في نفس الوقت + +65 +00:05:06,710 --> 00:05:11,270 +بيعمل انهي بيشيل لمين لتي البر تو pathway ايضا تي + +66 +00:05:11,270 --> 00:05:14,650 +البر تو pathway في وجود aisle 4, aisle 5 او aisle + +67 +00:05:14,650 --> 00:05:22,350 +4 بيصير تي البر 2 اللي بتفرز aisle 10 ماشي و aisle + +68 +00:05:22,350 --> 00:05:27,810 +12 طبعاالذين يعملون انهيبشين لمين؟ لـ Gamma + +69 +00:05:27,810 --> 00:05:30,650 +Interferon Production وبالتالي يعملون انهيبشين لـ + +70 +00:05:30,650 --> 00:05:34,730 +Macrophage Activation طبعا الـ TELPAR2 إذا كانت + +71 +00:05:34,730 --> 00:05:40,430 +نشطة نشط ليه؟ اللي هو الـ B-Lymphocytes and other + +72 +00:05:40,430 --> 00:05:44,730 +granulastic cell اللي طبعا B-Lymphocyte اتكون + +73 +00:05:44,730 --> 00:05:50,250 +Antibody فالـ TELPAR2 pathway هو عبارة عنأو الـ + +74 +00:05:50,250 --> 00:05:54,070 +Immunity Response بينما الـ T111 باثوين هو برنامج + +75 +00:05:54,070 --> 00:05:59,990 +Cell-mediated Immunity Pathway.Cytokine أيضًا يمكن + +76 +00:05:59,990 --> 00:06:02,790 +أن يسيطر على الـ Immunoglobulin Class-Switching + +77 +00:06:02,790 --> 00:06:09,650 +بمعنى أننا نعرف أن الـ Class-Switching يحدث على + +78 +00:06:09,650 --> 00:06:10,590 +الـ Cell المشغل + +79 +00:06:14,100 --> 00:06:22,380 +و الـ activated B lymphocytes لما بيصير فيه + +80 +00:06:22,380 --> 00:06:26,580 +chronic infection بتعمل class switching لل + +81 +00:06:26,580 --> 00:06:32,020 +antibody اللي بتكونه وبتحوله من IgM إلى other + +82 +00:06:32,020 --> 00:06:39,540 +types of antibody الشغل بيصير علىالـ FC Region + +83 +00:06:39,540 --> 00:06:43,380 +وليس الـ Fab Region زي ما اتفقنا في محاضرة سابقة + +84 +00:06:43,380 --> 00:06:48,700 +فالـ FC Region هي اللي بتتغير وبالتالي بتغير ال + +85 +00:06:48,700 --> 00:06:52,240 +class of antibodyواذا تغير ال class of antibody + +86 +00:06:52,240 --> 00:06:57,320 +تغيرت ال effector function of antibody لأنه اتغير + +87 +00:06:57,320 --> 00:07:03,500 +ال isotype الا دي isotype switching او class + +88 +00:07:03,500 --> 00:07:08,540 +switching بيتم فيها تغير ال antibody من class إلى + +89 +00:07:08,540 --> 00:07:11,280 +class تاني وطبعا اللي بي + +90 +00:07:14,770 --> 00:07:22,870 +الذي يفرز من الخلية الـ cytokine acting either + +91 +00:07:22,870 --> 00:07:28,930 +alone or in combination برضه أخدنا أمثلة على ذلك + +92 +00:07:28,930 --> 00:07:36,450 +أنه في وجود cytokine IL-4 على سبيل المثال يصير في + +93 +00:07:36,450 --> 00:07:45,130 +عند IL-5 IGE production أو IGGبينما في وجود other + +94 +00:07:45,130 --> 00:07:48,950 +cytokine بيصير فيها انها other types of antibody + +95 +00:07:48,950 --> 00:07:54,850 +طيب نبدأ نشوف الخلايا وظيفتهاوهي نبدأ بالـ + +96 +00:07:54,850 --> 00:07:57,510 +Macrophage وكنا بنعرف ان الـ Macrophage بتلعب دور + +97 +00:07:57,510 --> 00:08:00,870 +كبير في الـ innate و الـ acquired immunity الـ + +98 +00:08:00,870 --> 00:08:03,690 +innate immunity هي عبارة عن phagocystic cell بينما + +99 +00:08:03,690 --> 00:08:06,930 +في ال adaptive او acquired immunity بتشغل ك + +100 +00:08:06,930 --> 00:08:12,030 +antigen presenting cell لكن هذه الوظائف هي ليست + +101 +00:08:12,030 --> 00:08:15,410 +الوحيدة اللي بتقوم فيها ال Macrophage ان احنا + +102 +00:08:15,410 --> 00:08:19,190 +نتطلق الى وظائفها المختلفةHave Effective Functions + +103 +00:08:19,190 --> 00:08:20,130 +And Anti-Representation They are involved in + +104 +00:08:20,130 --> 00:08:25,010 +Initial Defense And Anti-Representation And Have + +105 +00:08:25,010 --> 00:08:30,410 +Effective Functions كما تشاهدون هؤلاء الـ Invading + +106 +00:08:30,410 --> 00:08:37,770 +Agents أخدته وابتلعته وإنشطت في أفرزات سايت القايم + +107 +00:08:37,770 --> 00:08:47,950 +في نفس الوقت قدّمته لـ DL Barcele فهي إماو إما + +108 +00:08:47,950 --> 00:08:55,270 +تقدموا لمن؟ لـ T-barcelena اللي تجعلها تجعلها + +109 +00:08:55,270 --> 00:08:55,770 +تجعلها تجعلها تجعلها تجعلها تجعلها تجعلها تجعلها + +110 +00:08:55,770 --> 00:08:58,690 +تجعلها تجعلها تجعلها تجعلها تجعلها تجعلها تجعلها + +111 +00:08:58,690 --> 00:08:58,690 +تجعلها تجعلها تجعلها تجعلها تجعلها تجعلها تجعلها + +112 +00:08:58,690 --> 00:08:58,870 +تجعلها تجعلها تجعلها تجعلها تجعلها تجعلها تجعلها + +113 +00:08:58,870 --> 00:08:59,330 +تجعلها تجعلها تجعلها تجعلها تجعلها تجعلها تجعلها + +114 +00:08:59,330 --> 00:08:59,330 +تجعلها تجعلها تجعلها تجعلها تجعلها تجعلها تجعلها + +115 +00:08:59,330 --> 00:09:06,410 +تجعلها تجعلها تجعلها تجعلها تجعلها تجعلها + +116 +00:09:06,410 --> 00:09:14,310 +تجعلها توفيها دي تيلد فانكشن للماكرفيش قالوا فيها + +117 +00:09:14,310 --> 00:09:17,670 +6 وظائف مختلفة منها بتلعب دور كبير في ال + +118 +00:09:17,670 --> 00:09:23,090 +inflammation news fever من خلال إفراز IL-6 human + +119 +00:09:23,090 --> 00:09:28,070 +cross factor alpha IL-1 which act as a pyrogen + +120 +00:09:28,070 --> 00:09:33,920 +بتلعب دور كبير في ال immunityby selection of + +121 +00:09:33,920 --> 00:09:37,780 +lymphocyte activated lymphocyte ففي عندنا ال aisle + +122 +00:09:37,780 --> 00:09:46,640 +12 بنشط يالبر 1 و aisle 4 بنشط يالبر 2 و ال + +123 +00:09:46,640 --> 00:09:51,400 +production of aisle 1 بعمل activation لل + +124 +00:09:51,400 --> 00:09:57,760 +lymphocyte and بعمل activation لها من خلال + +125 +00:09:57,760 --> 00:10:01,120 +processing and presentation of antigen لل + +126 +00:10:01,120 --> 00:10:08,020 +lymphocyteوظيفة تالتة Reorganization of tissue By + +127 +00:10:08,020 --> 00:10:11,860 +secretion of variety of factors زي Degradative + +128 +00:10:11,860 --> 00:10:17,160 +enzyme للأستيذ والهيروناديز والكولاجينيز وهي بتعمل + +129 +00:10:17,160 --> 00:10:22,420 +fibroblasts، stimulation, factors أو أيضا تساعد في + +130 +00:10:22,420 --> 00:10:28,220 +الانجيوجينيسيز وظيفة رابعة اللي هي بتفرز بعض + +131 +00:10:28,220 --> 00:10:32,020 +المواد اللي بتعمل damage لل tissueالهيدروليسيز + +132 +00:10:32,020 --> 00:10:37,360 +والهيدروجين بيركساي برودكشن كومبلمان C3A والتيومان + +133 +00:10:37,360 --> 00:10:43,080 +نكروس فاكتوره الفا الهدور كانت ميكروبيل من خلال + +134 +00:10:43,080 --> 00:10:47,820 +إفراز certain oxygen dependent products or + +135 +00:10:47,820 --> 00:10:50,780 +independent products + +136 +00:10:52,550 --> 00:10:57,590 +وانتي تيومر تعمل من خلال تكسيك فاكتر هيدروجين + +137 +00:10:57,590 --> 00:11:02,550 +بريكوساي كومبليمند روتيز نيتركوكسايد ميكانيزم + +138 +00:11:02,550 --> 00:11:06,130 +مختلف ابتلع بدوركل وبالتالي ال microphage لها + +139 +00:11:06,130 --> 00:11:11,510 +different مهمة جدا كخلية ويلها وظائف متعددة في + +140 +00:11:11,510 --> 00:11:17,450 +مجالات متعددة في ال immune response كيف تتنشط يعني + +141 +00:11:17,450 --> 00:11:20,270 +التنشيط + +142 +00:11:21,440 --> 00:11:25,420 +بيؤدى الى او نشطة ال macro phase من خلال + +143 +00:11:25,420 --> 00:11:30,940 +alteration in gene product خصة + +144 +00:11:30,940 --> 00:11:35,200 +بالجين اللى بيشتغل بتصير فيه وظيفة شوفنا توسطت + +145 +00:11:35,200 --> 00:11:39,600 +وظائف فهو ال expression of gene هو من يحدد نوع + +146 +00:11:39,600 --> 00:11:45,200 +الوظيفة اللى بتريد تقوم فيها تتنشط من خلالأيضا كان + +147 +00:11:45,200 --> 00:11:47,700 +هناك ميكانيزم يقولوا نمروا واحد بدا يعني two + +148 +00:11:47,700 --> 00:11:52,400 +signal يقولوا بدنا ال gamma interferon اللي جاي من + +149 +00:11:52,400 --> 00:11:59,300 +ايه؟ من T helper cell so T helper one plus + +150 +00:11:59,300 --> 00:12:03,220 +bacterial endotoxin يعني ال antigen اللي هو + +151 +00:12:03,220 --> 00:12:04,800 +اللايبوكوليساكرايدهان + +152 +00:12:08,680 --> 00:12:12,800 +Gamma interferon produced by telepergon زاد human + +153 +00:12:12,800 --> 00:12:18,700 +cross factor α يبقى سهول إن كان ال signal أولاً هي + +154 +00:12:18,700 --> 00:12:23,740 +عبارة عن Gamma interferon مع antigen أو Gamma + +155 +00:12:23,740 --> 00:12:28,180 +interferon مع human cross factor α بيؤدوا إلى نشاط + +156 +00:12:28,180 --> 00:12:33,180 +هذه الغاليه هي Gamma interferon في وجود الانتجن + +157 +00:12:33,180 --> 00:12:37,440 +هذا الانتجن ليبو بوليساكره عايزوهي الـ Gamma + +158 +00:12:37,440 --> 00:12:41,960 +Interferon أيضًا في وجود Human Necrosis Factor + +159 +00:12:41,960 --> 00:12:46,240 +Alpha اللي جاي من خلية ناشطة أيضًا بيؤدي إلى + +160 +00:12:46,240 --> 00:12:52,000 +various products of T lymphocytes يتحتاج إلى by + +161 +00:12:52,000 --> 00:12:56,340 +two different mechanism for activation of + +162 +00:12:56,340 --> 00:13:01,610 +macrophageننتقل إلى الخلية التانية وهي T-Cytotoxic + +163 +00:13:01,610 --> 00:13:14,330 +تطلع من الـ Thymus تطلع + +164 +00:13:14,330 --> 00:13:15,810 +من الـ Thymus تطلع من الـ Thymus تطلع من الـ + +165 +00:13:15,810 --> 00:13:16,330 +Thymus تطلع من الـ Thymus تطلع من الـ Thymus تطلع + +166 +00:13:16,330 --> 00:13:16,350 +من الـ Thymus تطلع من الـ Thymus تطلع من الـ + +167 +00:13:16,350 --> 00:13:16,350 +Thymus تطلع من الـ Thymus تطلع من الـ Thymus تطلع + +168 +00:13:16,350 --> 00:13:16,470 +من الـ Thymus تطلع من الـ Thymus تطلع من الـ + +169 +00:13:16,470 --> 00:13:16,470 +Thymus تطلع من الـ Thymus تطلع من الـ Thymus تطلع + +170 +00:13:16,470 --> 00:13:16,470 +من الـ Thymus تطلع من الـ Thymus تطلع من الـ + +171 +00:13:16,470 --> 00:13:16,470 +Thymus تطلع من الـ Thymus تطلع من الـ Thymus تطلع + +172 +00:13:16,470 --> 00:13:19,020 +من الـ Thymus تطلع منلكنها لازم لا تكون مدهشة + +173 +00:13:19,020 --> 00:13:24,060 +كافيا و لا تستطيع قتل الخلية حتى تكون عارفة بمعنى + +174 +00:13:24,060 --> 00:13:29,200 +لابد من تجييش الخلية عشان تستطيع أن تتصدى للانتجن + +175 +00:13:29,200 --> 00:13:34,660 +وغير عشان نجيش هذه الخلية وننشطها تحتاج إلى two + +176 +00:13:34,660 --> 00:13:39,950 +signalالأولى هي recognition by TCR أو Specific + +177 +00:13:39,950 --> 00:13:44,310 +Antigen Associated with Class I MHC Molecule يعني + +178 +00:13:44,310 --> 00:13:48,990 +لازم يتقدم لها الانتجن مرتبط بالـ MHC Molecule على + +179 +00:13:48,990 --> 00:13:54,270 +سطح الانتجن presenting cell والتاني exposure to + +180 +00:13:54,270 --> 00:13:57,990 +cytokine الـ cytokine IL-2 Gamma Interferon عادة + +181 +00:13:57,990 --> 00:14:02,810 +بيجينا من T-Helper I T-Helper Cell + +182 +00:14:05,350 --> 00:14:09,050 +وزي ما انتوا شايفين هى class 1-MSC مليكيويل مرتبطة + +183 +00:14:09,050 --> 00:14:14,010 +بانتيجين تقدم لمين؟ لـ Pre-T-Cytotoxic وبالتالي + +184 +00:14:14,010 --> 00:14:19,030 +اول خطوة من خطوات التنشيط الخطوة التانية لابد من + +185 +00:14:19,030 --> 00:14:21,390 +وجود انتيجين presenting cell اللى خدت الانتيجين + +186 +00:14:21,390 --> 00:14:24,950 +وعملت له processing وقدمته لتيه البرسيل اللى أفرزت + +187 +00:14:24,950 --> 00:14:32,040 +IL-2 وGamma انتكفيرةوبالتالي تحققت من الـ two + +188 +00:14:32,040 --> 00:14:37,340 +-signal أي تقدم الانتجن مع ال-MHC موليكيول وهي الـ + +189 +00:14:37,340 --> 00:14:41,300 +IL-2 مع Gamma Interferon وبالتالي صارت الـ pre-T + +190 +00:14:41,300 --> 00:14:45,520 +cell تحولت إلى can differentiate تحولت إلى + +191 +00:14:45,520 --> 00:14:50,020 +functioning T cell functional T cell يعني قادرة + +192 +00:14:50,020 --> 00:14:54,160 +على التصدي للأنتجن فتركها can recognize the + +193 +00:14:54,160 --> 00:14:59,190 +antigenاللي مرتبط بال MSC class 1 molecule اللي + +194 +00:14:59,190 --> 00:15:03,070 +على سطح الخلية المصابة اللي بنسميها target cell + +195 +00:15:03,070 --> 00:15:10,630 +وبيقتلها مباشرة كيف + +196 +00:15:10,630 --> 00:15:14,950 +تتم عملية القتل؟ جاله من صفات القتل انه it will be + +197 +00:15:14,950 --> 00:15:21,130 +antigen specific يعني لازم يكون فيه antigen وما + +198 +00:15:21,130 --> 00:15:29,120 +بتقتل اي خليةإنما لازم تكون حقيقي حالة لـ Antigen + +199 +00:15:29,120 --> 00:15:33,380 +نمرة اتنين It requires cell-to-cell contact ما + +200 +00:15:33,380 --> 00:15:39,740 +بتقتلها من خلال الأرتباط الـ HT cytotoxic capable + +201 +00:15:39,740 --> 00:15:44,240 +of killing many target cells يعني بتفتح .. حنشوف + +202 +00:15:44,240 --> 00:15:49,000 +إنها بتفك وتروح تمسك في إيش في خلية تانية + +203 +00:15:50,630 --> 00:15:56,790 +الميكانيزم للقتل يتم من خلال ان التيلينفوسايت تفرس + +204 +00:15:56,790 --> 00:16:01,050 +اتنين جرانيال لجرانيال هذي يبقى ال pair foreign و + +205 +00:16:01,050 --> 00:16:06,050 +لجرانزايم كل واحد له وظيفة قال upon contact with + +206 +00:16:06,050 --> 00:16:12,130 +targets الجرانيال contents release فشو بعمل قالوا + +207 +00:16:12,130 --> 00:16:16,280 +ال pair foreign polymerizeand form channel in + +208 +00:16:16,280 --> 00:16:20,340 +target cell membrane يعني بت بلمر على سطح الخلية + +209 +00:16:20,340 --> 00:16:27,900 +المصابة و بيكون channel ماشي ثم channel يعني يعمل + +210 +00:16:27,900 --> 00:16:33,880 +فتحة ثم لجرهنزين مخبر عن serine proteases بيدخل من + +211 +00:16:33,880 --> 00:16:38,190 +خلال ال channel هذه enter to the target cellAnd + +212 +00:16:38,190 --> 00:16:42,890 +activate casapases and nucleases و هذا بيقدي إلى + +213 +00:16:42,890 --> 00:16:46,990 +لعب أبتوسيز of target cell طبعا كلنا بنعرف ال + +214 +00:16:46,990 --> 00:16:52,150 +casapases و ال nucleases ميكانزم و كيف يتم تنشيطه + +215 +00:16:52,150 --> 00:16:59,440 +ميكانزم of killingأي البرفرن عمل ايه؟ عمل الـ + +216 +00:16:59,440 --> 00:17:03,840 +channel في الـ cell membrane والجرانزايم دخل من + +217 +00:17:03,840 --> 00:17:11,020 +خلال الـ channel وبالتالي قتل الخلية steps of in + +218 +00:17:11,020 --> 00:17:16,800 +cytotoxic killing كان الخطوات بالتمكالات نمرا واحد + +219 +00:17:16,800 --> 00:17:24,000 +ال T cytotoxic تتعرف على target cell المصابة ثم + +220 +00:17:24,000 --> 00:17:25,720 +بتعمل + +221 +00:17:28,170 --> 00:17:33,530 +اللي هو Clustering للـ Granules في منطقة المسكة ثم + +222 +00:17:33,530 --> 00:17:37,490 +بتعمل Lithial Hit يعني بتعمل Degranulation بيسموها + +223 +00:17:37,490 --> 00:17:41,170 +الدربة القاضية Lithial Hit is delivered by T + +224 +00:17:41,170 --> 00:17:45,970 +-Cytotoxic و ال Granules بتحتوي على ال Perforated + +225 +00:17:45,970 --> 00:17:51,600 +Legrands IMBوارفنا ايش دور الـPeripheral Graze عن + +226 +00:17:51,600 --> 00:17:56,280 +الـP بعد ما هدولة induce طبعا Aboptosis بعد ما + +227 +00:17:56,280 --> 00:18:01,360 +تفرزهم تعمل Detachment يعني Detach اللي بتنفصل + +228 +00:18:01,360 --> 00:18:05,180 +الخلية و بتروحه يمسك another target cell for + +229 +00:18:05,180 --> 00:18:12,720 +Aboptosis خلية أخرى من الخلايا المنعية اللي هي + +230 +00:18:12,720 --> 00:18:19,840 +الـNK cell وهو الـNK cell هي طالعة من البونمارولكن + +231 +00:18:19,840 --> 00:18:24,680 +مافي على سطحة لا TCR ولا على سطح بي أورتيسي + +232 +00:18:24,680 --> 00:18:31,760 +الريسبتور ومابتروحش على ال Thymusولكن يوجد على + +233 +00:18:31,760 --> 00:18:38,720 +سطحه ريسبتور CD56 وهو عبارة عن ماركر محدد لها + +234 +00:18:38,720 --> 00:18:45,600 +وCD16 وهو عبارة عن ريسبتور لـ FC portion of IGG + +235 +00:18:45,600 --> 00:18:51,220 +لذلك يسمونه FCR3 أو CD16 + +236 +00:18:53,070 --> 00:19:01,150 +أيضًا الـ IL-2 الـ cytokine يمكن أن يدفع الانكسيل + +237 +00:19:01,150 --> 00:19:03,790 +إلى الانفكاين الانفكايني الانفكايني الانفكايني + +238 +00:19:03,790 --> 00:19:08,090 +الانفكايني اللاكسل اللاكسل اللاكسل اللاكسل اللاكسل + +239 +00:19:08,090 --> 00:19:10,030 +اللاكسل اللاكسل اللاكسل اللاكسل اللاكسل اللاكسل + +240 +00:19:10,030 --> 00:19:12,110 +اللاكسل اللاكسل اللاكسل اللاكسل اللاكسل اللاكسل + +241 +00:19:12,110 --> 00:19:14,590 +اللاكسل اللاكسل اللاكسل اللاكسل اللاكسل اللاكسل + +242 +00:19:14,590 --> 00:19:17,190 +اللاكسل اللاكسل اللاكسل اللاكسل اللاكسل اللاكسل + +243 +00:19:17,190 --> 00:19:20,550 +اللاكسل اللاكسل اللاكسل اللالكنها ليست restricted + +244 +00:19:20,550 --> 00:19:25,570 +MHC يعني بتفرز الـ pair for لجرانزايم في عملية + +245 +00:19:25,570 --> 00:19:33,490 +القتل لكنها not MHC restricted وإنما + +246 +00:19:33,490 --> 00:19:38,890 +تتعرف على ال MHC titer اللي موجود على سطح ال + +247 +00:19:38,890 --> 00:19:46,530 +target cellماشي و قالوا ان this title is inversely + +248 +00:19:46,530 --> 00:19:56,350 +proportional to susceptibility + +249 +00:19:56,350 --> 00:20:02,850 +of target cell to killing of the anky cell to kill + +250 +00:20:02,850 --> 00:20:08,620 +the target cellكيف تتم العملية؟ يوجد على سطح + +251 +00:20:08,620 --> 00:20:13,940 +الانكي سيلتو ريسبتور واحد اسمه killer inhibitory + +252 +00:20:13,940 --> 00:20:19,540 +receptor وواحد اسمه killer activating receptor ال + +253 +00:20:19,540 --> 00:20:25,380 +killer inhibitory receptors recognize class I MHC + +254 +00:20:25,380 --> 00:20:29,000 +وإذا كان لجأة موجودة على سطح الخلية it will + +255 +00:20:29,000 --> 00:20:31,980 +prevent killing عشان هيك بيسموه inhibitory + +256 +00:20:31,980 --> 00:20:34,160 +للريسبتور + +257 +00:20:35,630 --> 00:20:44,750 +ماشي .. طيب ال .. أهم شيء من الفيروزة موجود مافيه + +258 +00:20:44,750 --> 00:20:48,580 +killingطب وذا مش موجود زي ما بيصير في حالات ال + +259 +00:20:48,580 --> 00:20:56,900 +infection ال virus intravenous او cellular antigen + +260 +00:20:56,900 --> 00:21:01,220 +can mask the MHC molecule على سطح الخلية وبالتالي + +261 +00:21:01,220 --> 00:21:06,320 +بيقل ال titration of MHC molecule فبالتالي ال KIR + +262 +00:21:07,410 --> 00:21:11,730 +بلا يتعرف على مين على الـ MHC موليكيول على سطح + +263 +00:21:11,730 --> 00:21:16,710 +الخلية فبتنشط ريسبتور تاني اسمه KAR على سطح الخلية + +264 +00:21:16,710 --> 00:21:25,390 +وبينشط الانكسيل for killing طريقة أخرى للقتل وهو + +265 +00:21:25,390 --> 00:21:33,250 +بيسموها اللي هو antibody dependent يعني IGGقلنا + +266 +00:21:33,250 --> 00:21:37,050 +الـ FC Portion of IgG له Receptor على سطح الـ + +267 +00:21:37,050 --> 00:21:44,190 +Ankyl Cell سمينا هذا الـ Receptor CD16 ويبدأ + +268 +00:21:44,190 --> 00:21:50,570 +يتعرف على الـ Antibody من خلال ميكانزم يسمونه Cell + +269 +00:21:50,570 --> 00:21:53,370 +-mediated أو Antibody-dependent Cell-mediated + +270 +00:21:53,370 --> 00:21:58,350 +Cytotoxicity ببساطة هذا أو الـ ADCC ببساطة هذا + +271 +00:21:58,350 --> 00:22:03,320 +الميكانزم تعرف عليه كالآتي يوم يدخل الـ Antigenهو + +272 +00:22:03,320 --> 00:22:08,500 +يتصدلوا antibody منه IGG كلنا بنعرف ان ال IGG هو + +273 +00:22:08,500 --> 00:22:12,440 +عبارة عن obsinine ما بيقدر يقتل ال antigen وانما + +274 +00:22:12,440 --> 00:22:17,900 +بيعلموا كيف بيعلموا بتبط في مين بيبقى فالت من ال + +275 +00:22:17,900 --> 00:22:24,470 +antibodyالـ IFC Portion هذا الـ IFC Portion لها + +276 +00:22:24,470 --> 00:22:30,370 +ريسبتور على سطح الانكي سل فبتروحي الانكي سل ماسكة + +277 +00:22:30,370 --> 00:22:36,370 +في الخلية الـ Opsiniase سل و برضه بتقتل بسل + +278 +00:22:36,370 --> 00:22:42,130 +Contact ترتبط فيها متى ما نبطط فيها تعمل عملية + +279 +00:22:42,130 --> 00:22:46,860 +Degranulation والـ Degranulation يعنيبيدوسير فيه + +280 +00:22:46,860 --> 00:22:52,940 +بيعرف إن Grand Zain بقتله الخدية تتكوّن الينفوكاين + +281 +00:22:52,940 --> 00:22:59,920 +Activated killer cell upon activation of NK cell و + +282 +00:22:59,920 --> 00:23:05,820 +هذه عند القدرة تكيل بوضر range of infected cell + +283 +00:23:05,820 --> 00:23:11,640 +طيب regulation of immune cell immune response يعني + +284 +00:23:11,640 --> 00:23:16,750 +لو في اكتر في regulation على اكتر من مجالالخلية + +285 +00:23:16,750 --> 00:23:19,250 +تستخدم كمية ميزاتية تستخدم كمية ميزاتية تستخدم + +286 +00:23:19,250 --> 00:23:22,370 +كمية ميزاتية تستخدم كمية ميزاتية تستخدم كمية + +287 +00:23:22,370 --> 00:23:23,230 +ميزاتية تستخدم كمية ميزاتية تستخدم كمية ميزاتية + +288 +00:23:23,230 --> 00:23:27,230 +تستخدم كمية ميزاتية تستخدم كمية ميزادية تستخدم + +289 +00:23:27,230 --> 00:23:29,390 +كمية ميزادية تستخدم كمية ميزادية تستخدم كمية + +290 +00:23:29,390 --> 00:23:29,470 +ميزادية تستخدم كمية ميزادية تستخدم كمية ميزادية + +291 +00:23:29,470 --> 00:23:30,970 +تستخدم كمية ميزادية تستخدم كمية ميزادية تستخدم + +292 +00:23:30,970 --> 00:23:35,350 +كمية ميزادية تستخدم كمية ميزادية تستخدموبالتالي + +293 +00:23:35,350 --> 00:23:39,090 +الـ Antigen بلعب دور كبير في عملية تحديد التلرنسي + +294 +00:23:39,090 --> 00:23:43,250 +يعني إذا احنا ناخد في محاضرة قادمة أن دخول ال + +295 +00:23:43,250 --> 00:23:47,590 +Antigen بكميات كبيرة له دور كبير في تحديد ال + +296 +00:23:47,590 --> 00:23:54,830 +immune response أيضا طريقة دخول ال Antigen له دور + +297 +00:23:54,830 --> 00:23:59,650 +كبير في تحديد ال immune response و ال types of + +298 +00:23:59,650 --> 00:24:04,930 +Antigen أيضا type of Antigensأيضا له دور في تحديد + +299 +00:24:04,930 --> 00:24:07,470 +ال immune response ان شاء الله بناخده في ال + +300 +00:24:07,470 --> 00:24:14,790 +tolerance هذا الكلام فال antigen هو من يحدد الخلية + +301 +00:24:14,790 --> 00:24:19,350 +تتنشط وتعطينا immune response او يصير في tolerance + +302 +00:24:19,350 --> 00:24:27,010 +بمعنى un responsiveness لل immune responseالمجال + +303 +00:24:27,010 --> 00:24:31,590 +الاخر هو specificities and functional classes of + +304 +00:24:31,590 --> 00:24:37,890 +lymphocyte activation نحن رأينا تأوي أن الـ T-cell + +305 +00:24:37,890 --> 00:24:46,730 +لها subset لها أنواع أخرى و طبعا كل نوع له خط سير + +306 +00:24:46,730 --> 00:24:50,150 +معين تهيأ البرواحة تدينا اللي هو + +307 +00:24:56,520 --> 00:25:01,380 +أيضًا الـ Regulatory Mechanism ممكن أبلجيها على + +308 +00:25:01,380 --> 00:25:04,980 +مستوى الـ recognition of أنتجن ال activation of + +309 +00:25:04,980 --> 00:25:08,900 +أنتجن or even of the cells or even the effector + +310 +00:25:08,900 --> 00:25:13,660 +phases of the immune response المختلفة وبالتالي في + +311 +00:25:13,660 --> 00:25:16,340 +Regulation وهذا مهم جدًا لأن ال Regulatory + +312 +00:25:16,340 --> 00:25:21,300 +Mechanism مهم جدًا لإيقاف ال immune response يوم + +313 +00:25:21,300 --> 00:25:29,420 +ما يخلص الانتجنماشي بيك تكون خلصنا هذه المحاضرة + +314 +00:25:29,420 --> 00:25:33,940 +ارجو ان تكونوا قد استفدتم منها و شكرا + diff --git a/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/wzDU4ZEOcSw_postprocess.srt b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/wzDU4ZEOcSw_postprocess.srt new file mode 100644 index 0000000000000000000000000000000000000000..b2004241cefdb7e1ad66651dea2a430c9d446313 --- /dev/null +++ b/PL9fwy3NUQKwaWoy71ndTkstYFxr9i7quZ/wzDU4ZEOcSw_postprocess.srt @@ -0,0 +1,2380 @@ +1 +00:00:02,190 --> 00:00:05,490 +بسم الله الرحمن الرحيم الصلاة والسلام علي سيد + +2 +00:00:05,490 --> 00:00:15,350 +القلق أجمعين سيدنا محمد الصادق الأمين و بعد سنلتقي + +3 +00:00:15,350 --> 00:00:21,630 +اليوم في مساكن مختلف نوعا ما و هو مناعة و الأمصال + +4 +00:00:21,630 --> 00:00:26,390 +المناعة و الأمصال المناعة تعريفا + +5 +00:00:28,100 --> 00:00:31,900 +في بعض الكتب تعرف بانها chemistry of cell احنا + +6 +00:00:31,900 --> 00:00:37,300 +هنحكي على خلايا و هنحكي على بعض العوامل المناعية + +7 +00:00:37,300 --> 00:00:42,380 +اللي بتكون دي هذه المناعة في ال lesson ال course + +8 +00:00:42,380 --> 00:00:50,140 +ان شاء الله شيق و هيكون فيه تفاعل بإذن الله قبل ما + +9 +00:00:50,140 --> 00:00:55,000 +نبدأ في ال course خلينا بس نوّق لها شغلة ان هو + +10 +00:00:56,190 --> 00:01:00,850 +الفصل هذا هيكون فيه امتحانين واحد نصفي واحد نهائي + +11 +00:01:00,850 --> 00:01:06,330 +النصفي هيكون فيه على ال model و هيكون عليه اربعين + +12 +00:01:06,330 --> 00:01:12,010 +درجة بينما النهائي هيكون في الجامعة ان شاء الله و + +13 +00:01:12,010 --> 00:01:18,230 +هيكون عليه ستين درجة بالنسبة للنصفي قد يتخلله quiz + +14 +00:01:18,230 --> 00:01:25,150 +أو quizzin بالاضافة لل .. للامتحان النصفي + +15 +00:01:27,800 --> 00:01:31,040 +مادة موجودة ان شاء الله ده هي slide powerpoint + +16 +00:01:31,040 --> 00:01:35,020 +موجودة وان شاء الله هشتغل فيها على ال model واحدة + +17 +00:01:35,020 --> 00:01:40,900 +واحدة week by week ونبدأ بأول محاضرة محاضرة الأولى + +18 +00:01:40,900 --> 00:01:47,240 +بتتكون من شقيين من محاضرتين من محاضرتين وهي عبارة + +19 +00:01:47,240 --> 00:01:49,700 +عن مقدمة بتلوم كل المساق + +20 +00:01:54,560 --> 00:01:58,360 +بالتالي هنتفرق إلى عناوين كثيرة مختلفة هذه + +21 +00:01:58,360 --> 00:02:04,380 +العناوين هتشمل مساق بشكل عام وبالتالي هيكون في بعض + +22 +00:02:04,380 --> 00:02:10,560 +النقاط اللي غير مترابطة في هذه المحاضرة انما من + +23 +00:02:10,560 --> 00:02:13,440 +خلال هذه المحاضرة ان شاء الله هتتعرف على جزيات + +24 +00:02:13,440 --> 00:02:19,920 +كبيرة من المناعة في المناعة و أيضا هتتعرف على بعض + +25 +00:02:19,920 --> 00:02:25,540 +المصطلحات المناعية الدارجةو بعد هيك ان شاء الله + +26 +00:02:25,540 --> 00:02:30,600 +بنفصلها جزئية جزئية، كل واحدة هتاخد chapter لحالها + +27 +00:02:30,600 --> 00:02:39,480 +منفصل و نبدأ على بركة الله، بداية لإيش المنع + +28 +00:02:39,480 --> 00:02:43,490 +مقلودة في الجسم؟ يعنيماهو هدف وجود المناقة في + +29 +00:02:43,490 --> 00:02:48,650 +الجسم؟ ماهي دورها؟ ماهي العوامل التي تكافح ضدها؟ + +30 +00:02:48,650 --> 00:02:55,290 +تقلخصوها في أربع عوامل أساسية يعني انها بتدافع + +31 +00:02:55,290 --> 00:03:00,610 +against infection and it also defense against + +32 +00:03:00,610 --> 00:03:03,870 +toxin it also defense + +33 +00:03:08,090 --> 00:03:14,170 +cancer whatever and it also بتلعب دور كبير في auto + +34 +00:03:14,170 --> 00:03:26,350 +immunity and in pregnancy المناعة + +35 +00:03:26,350 --> 00:03:32,470 +قسموها إلى أسمين أساسيين نوعين أساسيين جالوا في + +36 +00:03:32,470 --> 00:03:35,750 +عندنا مناعة باسمها innate immunity وفي adaptive + +37 +00:03:39,280 --> 00:03:43,900 +ولا درتم immunity لها خصائصها في هذه المحاضرة زى + +38 +00:03:43,900 --> 00:03:50,580 +ما قلتلكوا هنعمل هي كمسح لإيه وتعريفة لكل من هما + +39 +00:03:50,580 --> 00:03:55,620 +على أحدها ال innate immunity عرفوها بإن هى عبارة + +40 +00:03:55,620 --> 00:03:58,840 +عن broad range of mechanism ميكانيزمات متعددة + +41 +00:03:58,840 --> 00:04:04,060 +وكثيرة and it does not require selection of self + +42 +00:04:04,060 --> 00:04:13,290 +بمعنى it's not specificوبالتالي لا يوجد مجرد + +43 +00:04:13,290 --> 00:04:20,950 +ميكانيزم لقتل الأشياء المحددة الحاجة التالتة انها + +44 +00:04:20,950 --> 00:04:28,310 +موجودة منذ الولادة يعني موجودة على طول ماشي تخلق + +45 +00:04:28,310 --> 00:04:34,000 +في الإنسان على طول بينما ال adaptive immunityهو + +46 +00:04:34,000 --> 00:04:39,760 +محدد كما رأينا لذلك نحتاج إختار لجينات لإخفاء أو + +47 +00:04:39,760 --> 00:04:44,500 +قتل بطريقة محددة مرة اتنين يتطلب DNA Rearrangement + +48 +00:04:44,500 --> 00:04:49,960 +أكيد حيصل على عملية تصفيت للجينات بطريقة معينة + +49 +00:04:49,960 --> 00:04:53,420 +لتحديد + +50 +00:04:53,420 --> 00:05:00,170 +اللي هو التباين اللي موجود في الخلاياIt also have + +51 +00:05:00,170 --> 00:05:04,730 +resistance memory بمعنى أنه لما بتشتغل تدينا + +52 +00:05:04,730 --> 00:05:05,770 +memory cells + +53 +00:05:16,620 --> 00:05:19,420 +و زي ما انتوا شايفين هي ال innate immunity و ال + +54 +00:05:19,420 --> 00:05:22,100 +acquired immunity موجودة characteristic feature + +55 +00:05:22,100 --> 00:05:25,520 +for each ال innate universal بمعنى موجودة عند الكل + +56 +00:05:25,520 --> 00:05:29,540 +rapid سريع لإنها already موجودة ثم lacks of memory + +57 +00:05:29,540 --> 00:05:34,440 +مافي memory ان it's not specific بينما ال acquired + +58 +00:05:34,440 --> 00:05:37,840 +immunity it's not universal و هي دي نقطة مهمة مش + +59 +00:05:37,840 --> 00:05:43,370 +كل إنسان عنده مناعة زي التاني it's not universalمش + +60 +00:05:43,370 --> 00:05:47,470 +كل واحد فينا منعته زي التاني and slow to develop + +61 +00:05:47,470 --> 00:05:52,310 +تحتاج إلى وقت عشان تتكون و هنشوف عندنا كيف بت .. ب + +62 +00:05:52,310 --> 00:05:56,010 +.. ب .. عشان الوقت اللي لازم عشان ايش تتكون هذه + +63 +00:05:56,010 --> 00:06:01,770 +المنعة and it possess memory و طبيعي جدا يوم ما + +64 +00:06:01,770 --> 00:06:11,110 +تنشر تدينا memory cell و active cell also من ما + +65 +00:06:11,110 --> 00:06:14,780 +يميزها ايضابقولوا انها it plays to the tone of + +66 +00:06:14,780 --> 00:06:23,100 +innate immunity بمعناه انه بتتحرك بتتنشط حسب نشاط + +67 +00:06:23,100 --> 00:06:28,060 +ال innate immunity و هذه الصورة بتبين ان الخلايا + +68 +00:06:28,060 --> 00:06:32,560 +اللتي تشارك في ال innate و الخلايا اللتي تشارك في + +69 +00:06:32,560 --> 00:06:35,660 +ال adaptive طبعا كلكم بتعرف الصورة هذه شفناها في + +70 +00:06:35,660 --> 00:06:38,960 +ال hematology اللي هي ال hemopoietic tree و زي ما + +71 +00:06:38,960 --> 00:06:43,400 +انتوا شايفين هي كل الخلايااللي معلمة بالأحمر لدي + +72 +00:06:43,400 --> 00:06:47,460 +عليها نجمة حمراء هذه بتلعب دور كبير في الـ + +73 +00:06:47,460 --> 00:06:51,340 +Immunity بينما اللي عليها نجمة خضراء بتلعب دور + +74 +00:06:51,340 --> 00:06:54,440 +كبير في الـ Adaptive Immunity وزي ما انتوا شايفين + +75 +00:06:54,440 --> 00:06:57,640 +بتاعة الـ Adaptive هي mostly الـ lymphocyte بينما + +76 +00:06:57,640 --> 00:07:04,180 +الانهيط كل الخلايا الأخرى ممكن تلعب دور فيها نبدأ + +77 +00:07:04,180 --> 00:07:05,580 +نحكي على كل من هما + +78 +00:07:11,120 --> 00:07:14,500 +تخص ال adaptive immunity بيبقى بتمر في أربع مراحل + +79 +00:07:14,500 --> 00:07:20,400 +أساسية أربع مراحل أساسية المرحلة الأولانية هي + +80 +00:07:20,400 --> 00:07:26,600 +generation of cellular diversity وهذه generation + +81 +00:07:26,600 --> 00:07:29,560 +of cellular diversity بمعنى أنه تكوين تصنيع + +82 +00:07:29,560 --> 00:07:32,600 +الخلايا الملاعية والتصنيع دائما بيكون في ال + +83 +00:07:32,600 --> 00:07:35,520 +primary lymphoid organsوالـ Primary lymphoid + +84 +00:07:35,520 --> 00:07:38,380 +organs هي الـ bone marrow و الـ thymus ثم + +85 +00:07:38,380 --> 00:07:40,920 +selection of cells specific to a given antigen + +86 +00:07:40,920 --> 00:07:44,780 +بيصير عملية selection كل خلية بتتصدر لل antigen + +87 +00:07:44,780 --> 00:07:48,480 +الخاص ابقى ويهدب الكلام بتم في ال secondary + +88 +00:07:48,480 --> 00:07:51,420 +lymphoid organs زي ال lymph node و ال spleen و ال + +89 +00:07:51,420 --> 00:07:54,880 +because ال associated tissue يوم ما يمسك ال + +90 +00:07:54,880 --> 00:07:59,360 +antigen بالخلية المناسبة له أو العكسبصير في Clonal + +91 +00:07:59,360 --> 00:08:03,100 +Expansion المرحلة التالتة هي إيش؟ Clonal Expansion + +92 +00:08:03,100 --> 00:08:06,640 +أيضا بتتم في ال secondary lymphoid organs و طبعا + +93 +00:08:06,640 --> 00:08:12,400 +بيتمخد عن هذا النشاط أنه بتطلع لنا خلية ناشطة و + +94 +00:08:12,400 --> 00:08:18,260 +بيسموها active cell و في نفس الوجود بتطلع لنا خلية + +95 +00:08:18,260 --> 00:08:23,960 +dormant أو بيسموها memory cell dormant يعني ساكنة + +96 +00:08:23,960 --> 00:08:28,780 +فهي أربع مراحل أساسيةالخلايا المنعية اللي بتلعب + +97 +00:08:28,780 --> 00:08:31,100 +دول كبيرة في الاداتيب يقولون ان اتفاقنا هي عبارة + +98 +00:08:31,100 --> 00:08:34,860 +عن ال lymphocyte types و ال lymphocyte نعرف ان هي + +99 +00:08:34,860 --> 00:08:39,680 +بي و تي ماذا يميز كل منهم؟ هم جعلوا ال بي سل على + +100 +00:08:39,680 --> 00:08:44,920 +سطحه receptor و ال receptor بيسمو PCR يعني بي سل + +101 +00:08:44,920 --> 00:08:48,300 +receptor و هو عبارة عن immunoglobulin و عبارة عن + +102 +00:08:48,300 --> 00:08:53,900 +ايش immunoglobulin بينما ال T lymphocyte على سطحه + +103 +00:08:53,900 --> 00:09:01,680 +receptor اسمه TCRيعني T Cell Receptor اللي لا + +104 +00:09:01,680 --> 00:09:05,820 +يستطيع أن يتعرف على الانتجن بنفسه لحاله لا يستطيع + +105 +00:09:05,820 --> 00:09:08,620 +أن يتعرف على الانتجن طبعا كيف يستطيع أن يتعرف على + +106 +00:09:08,620 --> 00:09:14,740 +الانتجن؟ بيحتاج إلى انتجن تقدم سل الخلية بتقدم + +107 +00:09:14,740 --> 00:09:19,240 +الانتجن لميه؟ للـ T lymphocyte و بتاخد الانتجن و + +108 +00:09:19,240 --> 00:09:23,840 +بتعمله processing يعني بتقطع و بتطلع جزء منه على + +109 +00:09:23,840 --> 00:09:27,400 +سطحها مرتبط بموليكيول أخر اسمه MSC موليكيول + +110 +00:09:35,470 --> 00:09:38,570 +الحياة المنهية MRC هو عبارة عن major + +111 +00:09:38,570 --> 00:09:45,790 +histocompatibility complex بيقدم ال antigen لمي + +112 +00:09:45,790 --> 00:09:50,690 +لتي لمفوسايتس يبقى في أول مرحلة من المراحل هو + +113 +00:09:50,690 --> 00:09:53,350 +generation of ash of cellular diversity وزي ما + +114 +00:09:53,350 --> 00:09:56,710 +قلتلكم تم في مصانع الدم وهي ال bone marrow + +115 +00:09:56,710 --> 00:10:03,910 +والثيروس عملية التصنيع بالتم + +116 +00:10:05,690 --> 00:10:10,870 +لو حاولتنا نحكي على الـ B lymphocytes في الـ B + +117 +00:10:10,870 --> 00:10:14,410 +lymphocytes هي عبارة عن خلية تنشأ في البومارو و + +118 +00:10:14,410 --> 00:10:18,950 +تبقى في البومارو يعني تنضج في البومارو و العملية + +119 +00:10:18,950 --> 00:10:24,550 +بتتم ببساطة ان الخلايا ال immature تبدأ immature و + +120 +00:10:24,550 --> 00:10:28,370 +تصير mature و أثناء عملية ال maturation بتتم عملية + +121 +00:10:28,370 --> 00:10:35,300 +تصفيت الجينات تبعتها بطريقة معينةيعني في كل مرة + +122 +00:10:35,300 --> 00:10:40,040 +هذه الجينات بتتصفط بطريقة معينة أي جينات الجينات + +123 +00:10:40,040 --> 00:10:43,760 +تبعت ال immunoglobulin يعني تبعت مين؟ يعني تبعت ال + +124 +00:10:43,760 --> 00:10:48,400 +PCR ال بي سيرفسيبتل اللي بيطلع على سطحها وبالتالي + +125 +00:10:48,400 --> 00:10:55,480 +بينضج هذا ال PCR وبيطلع مرتبط على سطح الخلية و .. + +126 +00:10:57,450 --> 00:11:01,470 +مختلفة في كل مرة يبقى بيطلع ان ال receptor مختلف + +127 +00:11:01,470 --> 00:11:04,730 +في كل مرة على سطح الخلية و بقى ان ال receptor + +128 +00:11:04,730 --> 00:11:09,090 +مختلف على سطح الخلايا يبقى كل خلية بي .. is + +129 +00:11:09,090 --> 00:11:13,370 +specific only for one antigen is specific only for + +130 +00:11:13,370 --> 00:11:18,330 +one antigen ماشي يبقى لو عندناها مرة تانية الخلية + +131 +00:11:18,330 --> 00:11:23,350 +بتنشأ في ال .. بال .. بال bone marrow و تنضج في ال + +132 +00:11:23,350 --> 00:11:27,490 +bone marrow و أثناء عملية نضوجهابتم عملية تصفيت + +133 +00:11:27,490 --> 00:11:34,170 +الجينات المسئولة عن تصنيع ال PCR وبالتالي في كل + +134 +00:11:34,170 --> 00:11:38,410 +مرة هذه الجينات تتصفى تصفيتها مختلفة لأنه تصفيتها + +135 +00:11:38,410 --> 00:11:45,260 +شوية وبالتالي في كل مرة ينتج عندناBCR مختلف اللى + +136 +00:11:45,260 --> 00:11:51,000 +بيطلع قُبض على سطح الخلية وطبعا هذا الاختلافه + +137 +00:11:51,000 --> 00:11:56,380 +بيعني ان الخلايا مختلفة في ال specificity تبعتها + +138 +00:11:56,380 --> 00:12:03,000 +فكل خلية specific for specific أنتجة طبعا ما ينطبق + +139 +00:12:03,000 --> 00:12:07,060 +على ال B cell ينطبق على ال T cell بس كلنا بنعرف ان + +140 +00:12:07,060 --> 00:12:13,400 +البتنشأ في البونمارو لكن في مرحلة مبكرة جدا بتنتقل + +141 +00:12:13,400 --> 00:12:17,620 +من البونمارو إلى الـThymus وكلنا نعرف أن الـThymus + +142 +00:12:17,620 --> 00:12:23,540 +هي برعنة غدة صغيرة تتجاوز وزنها 40 جرام موجودة + +143 +00:12:23,540 --> 00:12:29,000 +overlying the heart يعني على مغطية جزء من القلب في + +144 +00:12:29,000 --> 00:12:33,240 +ال chest cavity وفيها + +145 +00:12:36,330 --> 00:12:42,090 +أو بتنضج الـ T-lymphocyte وعملية النضوج أيضًا + +146 +00:12:42,090 --> 00:12:46,730 +بينتج عنها تكوين cell surface markers على سطحها + +147 +00:12:46,730 --> 00:12:52,790 +أهمها اللي هو الـ TCR والـ TCR هو عبارة عن T Cell + +148 +00:12:52,790 --> 00:12:57,050 +Receptor بيقولوا إنه كل خلية بينتج عليها أو بيكون + +149 +00:12:57,050 --> 00:13:03,030 +على سطحها حوالي عشر أقوى سبعة TCR وبالتالي الخلية + +150 +00:13:03,030 --> 00:13:07,010 +بتنضجبعد ما تنضج بتطلع من الـ thymus على ال blood + +151 +00:13:07,010 --> 00:13:11,210 +circulation و من ال blood circulation بتروح على ال + +152 +00:13:11,210 --> 00:13:17,570 +secondary lymphoid organs فسألنا سؤال where and + +153 +00:13:17,570 --> 00:13:21,770 +how is B lymphocyte diversity related؟ طبعا طبعا + +154 +00:13:21,770 --> 00:13:25,490 +كلنا شرحنا انه في ال bone marrow يعني الجواب C هو + +155 +00:13:25,490 --> 00:13:29,890 +اللي صحطيب هذه الخطوة الأولانية وهي عبارة عن + +156 +00:13:29,890 --> 00:13:33,350 +generation of cellular diversity قلنا بعد هي كانت + +157 +00:13:33,350 --> 00:13:37,790 +تطلع الخلية ناضجة من المصنع وعلى blood circulation + +158 +00:13:37,790 --> 00:13:43,130 +وبتبدأ تحوم looking for antigen looking for إيش + +159 +00:13:43,130 --> 00:13:50,370 +its own antigen ماشي لجته كان بيها مالجتهوش طبعا + +160 +00:13:50,370 --> 00:13:55,530 +بتموت تولداي بعد عمر زمن محدد عمرهابتموت لكن إذا + +161 +00:13:55,530 --> 00:14:00,070 +لجت وبتروح ويجي مخدها ورايحة على ال secondary + +162 +00:14:00,070 --> 00:14:03,710 +lymphoid organs اللي هي lymph nodes, spleen, and + +163 +00:14:03,710 --> 00:14:07,470 +mycosis وبالتالي عملية ال selection for specific + +164 +00:14:07,470 --> 00:14:11,890 +action against specific antigen بتتم بالطوشة يعني + +165 +00:14:11,890 --> 00:14:17,750 +المعركة بتتم في ال secondary lymphoid organs وزي + +166 +00:14:17,750 --> 00:14:23,950 +ما انتوا شايفين هيو ال naive T and naive Bنيف يعني + +167 +00:14:23,950 --> 00:14:28,690 +اللي لسه طالع من المصنع طازة يعني لم تواجه antigen + +168 +00:14:28,690 --> 00:14:33,070 +بعد لأن وظيفتها انها تقابل antigen طبعا هدول هاتين + +169 +00:14:33,070 --> 00:14:35,810 +تين بيروحوا على ال secondary lymphoid organs وهن + +170 +00:14:35,810 --> 00:14:39,390 +برمي مثال على ال influenza spleen وزي ما انتوا + +171 +00:14:39,390 --> 00:14:43,130 +شايفين اذا كان يوم يدخل ال antigen بتاخدوا معاها + +172 +00:14:43,130 --> 00:14:48,030 +على هذا المكان وهن في احتمالين اذا كان ال antigen + +173 +00:14:48,030 --> 00:14:51,690 +لجته الخلية + +174 +00:14:55,530 --> 00:15:00,990 +الخلية بتموت بعد ومر زمان المحدد لكن اذا كان صادفة + +175 +00:15:00,990 --> 00:15:06,550 +الانتجين بي انتيلمفوسات survive عشان هيك ارتباطها + +176 +00:15:06,550 --> 00:15:10,410 +بالانتجين بيعتبروه survival signal ايش بيسموه + +177 +00:15:10,410 --> 00:15:13,990 +survival signal لإن بعدها بيصير في حاجة بيسموها + +178 +00:15:13,990 --> 00:15:21,400 +clonal expansion ايش يعني يعني بتبدأ الخلية تتنضج + +179 +00:15:21,400 --> 00:15:25,760 +تقبض عن قسم وتدّينا عدد كبير من الخلايا اللي جزء + +180 +00:15:25,760 --> 00:15:32,640 +منهم زيها active وجزء منهم بيكون memory يبقى + +181 +00:15:32,640 --> 00:15:36,100 +المرحلة التالتة هتكون Clonal Expansion وبرضه بتتم + +182 +00:15:36,100 --> 00:15:39,280 +في ال secondary lymphoid organs وزي ما تشوفين هي + +183 +00:15:39,280 --> 00:15:44,160 +ال B cell صارت Clonal Expansion وانقسمت تدتني + +184 +00:15:44,160 --> 00:15:48,300 +نوعين من الخلايا نوع سموه plasma cell اللي هو ال + +185 +00:15:48,300 --> 00:15:51,970 +active cellوالتاني هو عبارة عن إيه؟ ال memory cell + +186 +00:15:51,970 --> 00:15:56,830 +بنا ناخد فعل اعتبار أن ال memory cell لها نفس صفات + +187 +00:15:56,830 --> 00:16:00,610 +ال active cell لكنها dormant إيش يعني؟ ساكنة وقت + +188 +00:16:00,610 --> 00:16:04,070 +إيش بتنشط؟ يوم ما تصادف ال antigen مرة تانية، يوم + +189 +00:16:04,070 --> 00:16:06,810 +ما تصادف ال antigen مرة تانية طب ال active cell + +190 +00:16:06,810 --> 00:16:10,230 +إيش وظيفتها؟ ال B lymphocyte لما تتحول لبلازمة + +191 +00:16:10,230 --> 00:16:13,790 +cell وظيفتها إنها تنتج انها antibody، + +192 +00:16:13,790 --> 00:16:17,210 +immunoglobulin فتطلع antibody against مين؟ against + +193 +00:16:17,210 --> 00:16:24,820 +the antigenبالـ Clonal Expansion بينتج عنه Active + +194 +00:16:24,820 --> 00:16:27,420 +Cell و Memory Cell طبعاً ما ينطبق على الـ D + +195 +00:16:27,420 --> 00:16:30,380 +-Lymphocyte انطبق على الـ T-Lymphocyte وهذه الصورة + +196 +00:16:30,380 --> 00:16:33,080 +ده هي في عندنا Antigen Presenting Cell قدمت + +197 +00:16:33,080 --> 00:16:36,740 +الانتجن لـ T-Lymphocyte وصار لها إيش Activation + +198 +00:16:36,740 --> 00:16:40,880 +وClonal Expansion أدتنا كل أنواع الـ T-Cell اللي + +199 +00:16:40,880 --> 00:16:43,860 +هنتعرف عليها قدامها هي على الـCytotoxic وعلى الـT + +200 +00:16:43,860 --> 00:16:47,940 +-Helper وأيضاً أدتنا Memory Cell من كل نوع من هذه + +201 +00:16:47,940 --> 00:16:51,630 +الأخرانطبعا وصلنا في النهاية إلى إنه في عندنا حاجة + +202 +00:16:51,630 --> 00:16:55,850 +بيسموها mature و functional mature cells و هي + +203 +00:16:55,850 --> 00:16:58,910 +الخلايا النادجة و المرحلة الأخرى اللي بتقدي + +204 +00:16:58,910 --> 00:17:02,870 +وظيفتها ف ال B lymphocyte لما بيصير mature بتدينا + +205 +00:17:02,870 --> 00:17:06,630 +plasma cell و ال plasma cell زي ما انتوا شايفين ده + +206 +00:17:06,630 --> 00:17:14,570 +هي منطلعالي antibody بينما ال T lymphocyte لما + +207 +00:17:14,570 --> 00:17:20,340 +بتنضج سلقلونةExpansion ويدّيني أنواع مختلفة من + +208 +00:17:20,340 --> 00:17:25,800 +الـT lymphocyte وفي نفس الوقت برضه بتدّيني بيمرسل + +209 +00:17:25,800 --> 00:17:32,920 +لكل نوع من أنواع الخلايا اللي اتمشطت هنا برضه سؤال + +210 +00:17:32,920 --> 00:17:35,500 +what does the term clonal expansion mean؟ احنا + +211 +00:17:35,500 --> 00:17:40,660 +طبعا شرحنا clonal expansion ان الخلية تكون لـclone + +212 +00:17:40,660 --> 00:17:45,140 +of cell من نفس النوعماشي و زي ما قلتلكوا نفس النوع + +213 +00:17:45,140 --> 00:17:51,260 +في جزء منه active وجزء منه air وجزء منه ساكن طبعا + +214 +00:17:51,260 --> 00:17:58,600 +الإجابة all of the above طيب + +215 +00:17:58,600 --> 00:18:02,760 +in the generation of cellular diversity ليش ال + +216 +00:18:02,760 --> 00:18:05,660 +lymphocytes النشطة اللي طلعت الخلية النشطة اللي + +217 +00:18:05,660 --> 00:18:11,340 +طلعت ليش بتهجمش our own antigenقالوا لأنه في حالة + +218 +00:18:11,340 --> 00:18:18,940 +في الجسم اسمها tolerance و ال tolerance نوعين حدث + +219 +00:18:18,940 --> 00:18:24,440 +بيصير اما central و اما peripheral عشان هيك فينا + +220 +00:18:24,440 --> 00:18:28,510 +central tolerance و peripheral tolerancecentral + +221 +00:18:28,510 --> 00:18:33,390 +tolerance هو التخلص من كل ال self-reactive + +222 +00:18:33,390 --> 00:18:37,430 +lymphocyte self-reactive يعني إيش؟ يعني الخلايا + +223 +00:18:37,430 --> 00:18:41,850 +الناشطة ضد أنتجيناتنا الخاصة self our own antigen + +224 +00:18:41,850 --> 00:18:46,950 +يعني ماشي على طول لو طلعت خلية ناشطة ضد أنتجيناتنا + +225 +00:18:46,950 --> 00:18:52,870 +الخاصة الجسم يتخلص منها بيتخلص منها في المصنع وين + +226 +00:18:52,870 --> 00:18:55,590 +بتخلص منها في المصنع عشان هيك يسموه central + +227 +00:18:55,590 --> 00:19:00,140 +toleranceالنوع التانى اللى هو peripheral tolerance + +228 +00:19:00,140 --> 00:19:03,600 +اللى لو خلية فلتت من المصنع وطلعت برا blood + +229 +00:19:03,600 --> 00:19:06,640 +circulation شو بيصير؟ قالوا بيصير peripheral + +230 +00:19:06,640 --> 00:19:09,180 +tolerance ايش اللى بيصير؟ قالوا اما بيصير + +231 +00:19:09,180 --> 00:19:14,360 +suppression يعني بيوقف نشاطها للخلية فى ميكانزمات + +232 +00:19:14,360 --> 00:19:21,640 +بتوقف نشاطها او بيصير + +233 +00:19:21,640 --> 00:19:28,270 +فى killing by apoptosisهنشوف برضه chapter كامل على + +234 +00:19:28,270 --> 00:19:32,790 +هذا الموضوع و بما أننا بنحكي على الابوبتوسز ضالون + +235 +00:19:32,790 --> 00:19:36,910 +نتذكر المعلومة اللي أخدتوها سابقا الفرق بين + +236 +00:19:36,910 --> 00:19:39,930 +الابوبتوسز و النيكروسز واحدة associated with + +237 +00:19:39,930 --> 00:19:43,410 +inflammation والتانية not associated with + +238 +00:19:43,410 --> 00:19:46,330 +inflammation الابوبتوسز هي عبارة عن normal process + +239 +00:19:46,330 --> 00:19:50,550 +بيحصل في الجسم بدون inflammatory reaction بينما + +240 +00:19:50,550 --> 00:19:54,370 +النيكروسز هي عبارة عن inflammatory reaction + +241 +00:19:54,370 --> 00:19:59,100 +associated processو هذا ال central killer تتبع ال + +242 +00:19:59,100 --> 00:20:03,320 +B lymphocyte فالمصنع يا بنات لو اي خلية او يا شباب + +243 +00:20:03,320 --> 00:20:10,120 +اي خلية ماشي طلعت نشطة for our own antigen على طول + +244 +00:20:10,120 --> 00:20:15,060 +بيصير عملية قتل لها في داخل المصنع و بيقولوا انه + +245 +00:20:15,060 --> 00:20:20,460 +من 25 ل 50% of mature B lymphocyte تطلع نشطة و + +246 +00:20:20,460 --> 00:20:24,690 +بالتالي بيصيرها عملية eliminationما ينطبق على ال P + +247 +00:20:24,690 --> 00:20:26,850 +-Lymphocyte ينطبق على ال T-Lymphocyte وT + +248 +00:20:26,850 --> 00:20:30,150 +-Lymphocyte برضه بيصير في المصنع وين المصنع تاعة + +249 +00:20:30,150 --> 00:20:35,690 +ال T اللي هو ال Thymus فالنهاية T-Lymphocyte اما + +250 +00:20:35,690 --> 00:20:39,670 +بتطلع CD4 او CD8 اكيد هذا الكلام تعرفوه ان شاء + +251 +00:20:39,670 --> 00:20:44,490 +الله هنعرفه ده بالتفصيل و طبعا كل من هما ينطبط بال + +252 +00:20:44,490 --> 00:20:50,430 +Antigen من خلال ال MHC molecule تبعه و هنشوفقصها + +253 +00:20:50,430 --> 00:20:53,830 +اسمه ايش لما تشي موليكيول جاله هو عبارة عن major + +254 +00:20:53,830 --> 00:20:58,430 +histocompatibility complex و هذا عبارة عن cell + +255 +00:20:58,430 --> 00:21:01,390 +surface موليكيول موجودة على ال antigen presenting + +256 +00:21:01,390 --> 00:21:05,810 +cell في منهم نوعين class 1 و class 2 و they are + +257 +00:21:05,810 --> 00:21:11,710 +heritable و polymorphic و unheritable و ان شاء + +258 +00:21:11,710 --> 00:21:15,590 +الله هنحكي فيهم بالتفصيل بإذن الله جاله ما يفرق + +259 +00:21:15,590 --> 00:21:19,520 +واحد عن اتنين structurallyإن واحد إله one binding + +260 +00:21:19,520 --> 00:21:26,260 +site بينما one chain binding site بينما class two + +261 +00:21:26,260 --> 00:21:33,220 +إله two chain binding sites وهذا هي الصورة واضحة + +262 +00:21:33,220 --> 00:21:38,340 +في ال MSC class واحد إله بس اللي هو one binding + +263 +00:21:38,340 --> 00:21:42,140 +site one chain binding site بينما ال MSC class two + +264 +00:21:42,140 --> 00:21:46,140 +التنتين برتبته من إيش؟ من ال antigen + +265 +00:21:48,940 --> 00:21:53,460 +وانا كي بتنمي عملية اللي هو قتل الانتجن جاهزه ال + +266 +00:21:53,460 --> 00:21:57,440 +MSC class 1 is specific for internal antigen بينما + +267 +00:21:57,440 --> 00:22:05,160 +class 2 is defensing against external antigen ال + +268 +00:22:05,160 --> 00:22:09,300 +protein or ال antigen are processed presented by + +269 +00:22:09,300 --> 00:22:12,400 +MSC class 1 و بتقدم + +270 +00:22:14,880 --> 00:22:19,260 +الأنتجين لمن؟ لانه لـ CD8 Positive T-Lymphocyte + +271 +00:22:19,260 --> 00:22:23,780 +يعني الـ T-Lymphocyte اللي على سطح الـ CD8 و بينما + +272 +00:22:23,780 --> 00:22:28,320 +ال MSC Class II اللي هو موجود على الـ Antigen + +273 +00:22:28,320 --> 00:22:33,480 +Presenting Cell بيقدّم الانتجين لـ CD4 T + +274 +00:22:33,480 --> 00:22:40,360 +-Lymphocyte. External pathogen are complexed by + +275 +00:22:40,360 --> 00:22:45,700 +immunoglobulin merguleالـ external بيتصدى و الانتج + +276 +00:22:45,700 --> 00:22:48,940 +بيتصدى له immunoglobulin بينما ال internal + +277 +00:22:48,940 --> 00:22:55,200 +الانتجين بيقتل بواسطة ال cytotoxic lymphocytes طيب + +278 +00:22:55,200 --> 00:23:00,890 +احنا حكينا علىعلى اللي هو CD8 ماشي بتعمل و ال B + +279 +00:23:00,890 --> 00:23:05,250 +لنفسها CD4 شو وظفتها؟ قالوا إلها وظائف مختلفة + +280 +00:23:05,250 --> 00:23:10,730 +تخيلوا هي من يلعب ال major orchestral functions + +281 +00:23:10,730 --> 00:23:15,430 +يعني الوظائف الأساسية هي من يوزع المهام على + +282 +00:23:15,430 --> 00:23:22,000 +الخلايا الأخرى يبقى مهمة ولا مش مهمة؟ أكيد مهمةمش + +283 +00:23:22,000 --> 00:23:26,220 +وظفتها؟ قالوا بتلعب دور كبير في إنتاج cytokine + +284 +00:23:26,220 --> 00:23:33,060 +خاصة ماشي لمين؟ قالوا لل B lymphocyte عشان تعمل + +285 +00:23:33,060 --> 00:23:36,460 +class switching and memory cell formation يعني + +286 +00:23:36,460 --> 00:23:39,380 +بتساعد ال B lymphocyte واحنا خدهم هدولة بالتفصيل + +287 +00:23:39,380 --> 00:23:43,260 +تجلجوش تعرفولي على class switching يعني .. يعني + +288 +00:23:43,260 --> 00:23:45,500 +الخلية بتجلب + +289 +00:23:50,900 --> 00:23:58,260 +يطلع منه IGE whatever IGG بيصير او IGM بيصير IGG و + +290 +00:23:58,260 --> 00:24:07,940 +هكذا نمرا اتنين they provide ايضا بيساعدوا + +291 +00:24:07,940 --> 00:24:17,800 +في انتاج site و كاين خاصة بتساعد ال CD8 positive T + +292 +00:24:17,800 --> 00:24:25,240 +lymphocyteعشان تشتغل طبوش كمان جالو كمان بتلعب دور + +293 +00:24:25,240 --> 00:24:32,080 +كبير في .. في ايش؟ في تنشيط ال macro phase تنشيط + +294 +00:24:32,080 --> 00:24:34,180 +.. يعني بتساعد خلي اسمها T delayed type + +295 +00:24:34,180 --> 00:24:37,560 +hypersensitivity وظيفته الأساسية إنها تتنشط ال + +296 +00:24:37,560 --> 00:24:41,720 +macro phase في منطقات ال antigen في منطقات ال + +297 +00:24:41,720 --> 00:24:48,250 +antigen طيب إيش ال CD4 و CD8 بلعبوا أو كبوا؟ما هو + +298 +00:24:48,250 --> 00:24:52,550 +دورهم في الـ Central Tolerance During Developing T + +299 +00:24:52,550 --> 00:25:00,350 +-Lymphocyte؟ أو بين أخوهم كيف يتكوّنوا الـ CD4 + +300 +00:25:00,350 --> 00:25:06,470 +والـ CD8؟ كانوا يتكوّنوا من خلال عملية بيسموها الـ + +301 +00:25:06,470 --> 00:25:10,030 +T-cell education process، الـ T-cell education + +302 +00:25:10,030 --> 00:25:14,390 +process. أثناء، وأنا هحكي لكيها بالتفصيل هيك على + +303 +00:25:14,390 --> 00:25:20,530 +السريع،بتم الحكاية يوم تنتقل في مرحلة مبكرة جدا + +304 +00:25:20,530 --> 00:25:24,850 +بتنتقل خلية من الـT lymphocyte الغير ناضجة إلى + +305 +00:25:24,850 --> 00:25:29,210 +الـThymus يعني في مرحلة مبكرة جدا بيصل الـThymus + +306 +00:25:29,210 --> 00:25:33,010 +خلية غير ناضجة غير ناضجة من أيه؟ من الـT + +307 +00:25:33,010 --> 00:25:37,550 +lymphocyte بسموها precursor T-cell precursor يعني + +308 +00:25:37,550 --> 00:25:42,610 +أيه؟ خلية غير ناضجة طبعا أول ما تصل الـThymus هناك + +309 +00:25:42,610 --> 00:25:48,750 +بتقابلها خلايا بسموهاin nursing epithelial cells + +310 +00:25:48,750 --> 00:25:56,110 +من اسم nursing بتقدم ال antigen لمين لهذه + +311 +00:25:56,110 --> 00:26:05,110 +الخلايا و في هذه المرحلة لابد ان الخلية تتعرف على + +312 +00:26:05,110 --> 00:26:08,990 +antigen تتعرف على ايش على ال antigenات اللي + +313 +00:26:08,990 --> 00:26:14,980 +بتقدملها فالخلايا الشاطرة بتتعرف وبتمسكبينما + +314 +00:26:14,980 --> 00:26:17,840 +الخلايا اللتي لا تتعرف على ال antigen تقول die by + +315 +00:26:17,840 --> 00:26:21,880 +amortosis يبقى فرزنا أول عملية فرز أنه اللي صار + +316 +00:26:21,880 --> 00:26:26,040 +فيه عملية تعليم للخلية امتحانوها بامتحان غير + +317 +00:26:26,040 --> 00:26:30,520 +جدمولها antigen اتعرفت عليه اللي اتعرفت عليه هذا + +318 +00:26:30,520 --> 00:26:36,340 +هي عياشه هذا هي مال اتعايشها بينما اللي ما اتعرفت + +319 +00:26:36,340 --> 00:26:41,200 +عليه it was die by عياشه by amortosis طبعا بعد هي + +320 +00:26:41,200 --> 00:26:47,410 +كان في مرحلة قد ما بتنزل من الجدار الاتثايمس الى + +321 +00:26:47,410 --> 00:26:53,610 +deeper through the cortex و هناك بتصادف الخلايا + +322 +00:26:53,610 --> 00:26:56,870 +epithelial cells من نوع تاني بيسموها + +323 +00:26:56,870 --> 00:27:01,770 +Interdigitating cells Interdigitating cells ايش ال + +324 +00:27:01,770 --> 00:27:04,530 +Interdigitating cells بتعمل؟ بتروح ينقدم ال + +325 +00:27:04,530 --> 00:27:09,390 +antigen مرتبط بالامد C مليكيول مرتبط مين؟ بالامد C + +326 +00:27:09,390 --> 00:27:16,230 +مليكيولself-antigen مرتبط بالعمل C-molecule ويتقدم + +327 +00:27:16,230 --> 00:27:19,230 +للتليفوسة طبعا ما زال self-antigen المفروض ان + +328 +00:27:19,230 --> 00:27:22,790 +الخلايا تتعرف عليه ك self وما ترتبط فيه فالخلايا + +329 +00:27:22,790 --> 00:27:26,250 +اللي ما ترتبط فيه بتظل عايشة بينما اللي بترتبط فيه + +330 +00:27:26,250 --> 00:27:31,490 +بتموت يبقى سهل في عندي عمليتين فرص العملية + +331 +00:27:31,490 --> 00:27:35,030 +الأولانية بتقدم ال antigen self-antigen وغالبا + +332 +00:27:37,580 --> 00:27:40,100 +الأنتجن بيكون الـ MHC موليكيول على سطح الخلايا، + +333 +00:27:40,100 --> 00:27:44,340 +اتقدم لمين؟ للـ T-Lymphocyte، كامتحان أول الخلايا + +334 +00:27:44,340 --> 00:27:47,700 +اللي بتتعرف عليها و بتتبت فيه، بتدل عايشة، و + +335 +00:27:47,700 --> 00:27:51,080 +بيسموه Positive Selection، إيش يعني؟ اللي مسكن، هي + +336 +00:27:51,080 --> 00:27:53,760 +اللي دلت عايشة، و اللي ما اتعرفت عليه، بتقول، Bye + +337 +00:27:53,760 --> 00:27:57,900 +Bye، أموتوزيس، في مرحلة متقدمة الـ Interdigitating + +338 +00:27:57,900 --> 00:28:01,300 +cell بتقدم نفس الأنتجن اللي هو MHC موليكيول، مرتبط + +339 +00:28:01,300 --> 00:28:05,600 +بـ Self-antigen، مرتبط بمين؟ بـ Self-antigenطبعاً + +340 +00:28:05,600 --> 00:28:09,480 +في هذه الحالة لازم تتعرف عليه كself وما ترتبط بفيه + +341 +00:28:09,480 --> 00:28:13,320 +اللي ما بترتبط بتقول survive بينما اللي بترتبط + +342 +00:28:13,320 --> 00:28:17,160 +بتقول bye bye ايهش بيقى مبتوسس طبعاً في هذه الحالة + +343 +00:28:17,160 --> 00:28:19,560 +هذا الكلام مون بيسير بيسير غالباً في ال cortex + +344 +00:28:19,560 --> 00:28:26,380 +وبتكون الخلية على سطحه CD4 و CD8 ويسموها double + +345 +00:28:26,380 --> 00:28:30,080 +positive ليش double positive لأن عليها CD4 و CD8 + +346 +00:28:30,080 --> 00:28:34,600 +تنتيناللي بعد هيك بتنزل شوية ديبر في المضلة بتفقد + +347 +00:28:34,600 --> 00:28:39,460 +واحد منهم اللي ما اشتغل اللي ماانمسك بال antigen + +348 +00:28:39,460 --> 00:28:42,480 +سابقا هو اللي بيروح فبيضل واحد منياش من الاتنين + +349 +00:28:42,480 --> 00:28:46,220 +شغال عشان هيك الخلايا بعد هيك بتطلع انها اما CD4 + +350 +00:28:46,220 --> 00:28:55,180 +واما CD8 طيب طلعت الخلية ناشطة اما CD4 واما CD8 + +351 +00:28:59,070 --> 00:29:01,970 +بعد هي كانت بتروح و هي على ال blood circulation و + +352 +00:29:01,970 --> 00:29:07,170 +من ال blood circulation homing يعني بتدور بتدلل + +353 +00:29:07,170 --> 00:29:11,590 +ملفها لغاية ما تصادف ال antigen و قولنا بتاخده على + +354 +00:29:11,590 --> 00:29:13,850 +ال secondary lymphoid organs و هناك بيصير في + +355 +00:29:13,850 --> 00:29:18,130 +selection ماشي طب كيف بيصل ال antigen ل secondary + +356 +00:29:18,130 --> 00:29:24,830 +lymphoid organs قالوا في أكتر من طريقة بس حصروهم + +357 +00:29:24,830 --> 00:29:29,320 +في تلات طرق أساسيةالطريقة الأولانية through + +358 +00:29:29,320 --> 00:29:31,980 +lymphatic ducts اللي هو عبارة عن المواسير اللي + +359 +00:29:31,980 --> 00:29:36,640 +بتوصل لمن؟ لل lymphatic lymph nodes or through + +360 +00:29:36,640 --> 00:29:41,240 +blood ما هو ال blood بيخش في كل أنحاء الجسم و + +361 +00:29:41,240 --> 00:29:43,820 +مضمنها ال spleen و ال spleen secondary lymphoid + +362 +00:29:43,820 --> 00:29:48,480 +organs or directly to lymph node to lymphoid + +363 +00:29:48,480 --> 00:29:52,420 +tissue من خلال ال mycosal associated tissue اللي + +364 +00:29:52,420 --> 00:29:56,480 +هو gut associated lymphoid tissue + +365 +00:29:59,010 --> 00:30:03,330 +وهذا مثال مضموب عليها المالة الـ Mucosa الـ + +366 +00:30:03,330 --> 00:30:06,890 +associated lymphoid tissue جالو فيه lymph أمثل + +367 +00:30:06,890 --> 00:30:13,830 +بتبطن جدار العمعاق هي اللتي تتعرف على ال antigen و + +368 +00:30:13,830 --> 00:30:20,010 +بتدخل way directly to the lymph lymphocyte region + +369 +00:30:20,010 --> 00:30:25,410 +و بيسموها marginal zone or germinal centerهذه + +370 +00:30:25,410 --> 00:30:30,990 +الأمثلة أخذت الانتجين ودخلته مباشرة طبعا في + +371 +00:30:30,990 --> 00:30:34,210 +المناطق هذه اللي هي مرع الميكوز الـassociated + +372 +00:30:34,210 --> 00:30:37,210 +tissue في عندنا T-cell وفي عندنا B-cell وفي عندنا + +373 +00:30:37,210 --> 00:30:42,010 +Macrophage طبعا هدولة يمكن يشتغلوا كانتجين + +374 +00:30:42,010 --> 00:30:46,130 +presenting cell بيقدموا الانتجين لمين؟ للـT-cell + +375 +00:30:46,130 --> 00:30:51,910 +هذا ال lymph nodes نفس الحكاية وبين إن ال + +376 +00:30:51,910 --> 00:30:57,290 +lymphatic ductsالتي توصل بين الـ lymph nodes و + +377 +00:30:57,290 --> 00:31:01,830 +الـSpleen يعني جزئين كما تشاهدون جزء أبيض وجزء + +378 +00:31:01,830 --> 00:31:06,150 +أحمر جزء الأحمر خاص بالـRBCs بينما الجزء الأبيض + +379 +00:31:06,150 --> 00:31:09,950 +خاص بالـYBCs وفيه الـGerminal Center Area اللي + +380 +00:31:09,950 --> 00:31:13,370 +فيها both B-Lymphocyte وT-Lymphocyte وAntigen + +381 +00:31:13,370 --> 00:31:19,870 +-Presenting Cell أيه Free Antigen is necessary for + +382 +00:31:19,870 --> 00:31:24,290 +survivaland proliferation of antigens لكوبستر تثبت + +383 +00:31:24,290 --> 00:31:30,250 +الخلايا بالانتجن بتعتبر أخدت ال survival signal + +384 +00:31:30,250 --> 00:31:36,530 +ناشي اللي بتخليها تبعد هي كسلها proliferation و + +385 +00:31:36,530 --> 00:31:41,110 +expansion طبعا + +386 +00:31:41,110 --> 00:31:45,110 +الانتجن برضه ممكن يكون في داخل ال-dendritic cell + +387 +00:31:45,110 --> 00:31:48,230 +ال-dendritic cell بالمناسبة يعمل عن professional + +388 +00:31:48,230 --> 00:31:53,290 +antigen presenting cellأو بيسموها super antigen + +389 +00:31:53,290 --> 00:31:59,530 +presenting cell وهي طبعا هي ضرورية لتقديم ال + +390 +00:31:59,530 --> 00:32:06,010 +antigen في .. في .. لل T-lymphocyte هنا بنعت عبارة + +391 +00:32:06,010 --> 00:32:09,610 +عن جدول بيفرقلي ما بين ال professional antigen + +392 +00:32:09,610 --> 00:32:12,210 +presenting cell التلاتة Dendritic cell و + +393 +00:32:12,210 --> 00:32:16,810 +macrophage و ال B-lymphocytes وصفات كل واحد منهم و + +394 +00:32:16,810 --> 00:32:25,540 +الجدول موضح في كل حاجةوبرضه هنا نتعرف على الأربع + +395 +00:32:25,540 --> 00:32:30,860 +أنواع مختلفة من الـdendritic cell ومصادرها عشان + +396 +00:32:30,860 --> 00:32:34,640 +هيك لليوم نعرفش أحنا مصدر أساسي تبع مين تبع + +397 +00:32:34,640 --> 00:32:40,760 +الـdendritic cell وهنا dendritic cell بتبينلنا + +398 +00:32:40,760 --> 00:32:48,440 +مثال حي جداDendritic cell يعني تحت جدار ال skin + +399 +00:32:48,440 --> 00:32:53,460 +يوم ينضرب ال skin و يخش ال antigen ده هي البكتيريا + +400 +00:32:53,460 --> 00:32:57,360 +على طول مين بيتلقفها اللي هو ال antigen presenting + +401 +00:32:57,360 --> 00:33:01,800 +cell متمثل بمين بال dendritic cell + +402 +00:33:18,100 --> 00:33:19,540 +أو اتصال اميوني محدود اتصال اميوني محدود اتصال + +403 +00:33:19,540 --> 00:33:22,320 +اميوني اتصال اميوني اتصال اميوني اتصال اميوني + +404 +00:33:22,320 --> 00:33:23,640 +اتصال اميوني اتصال اميوني اتصال اميوني اتصال + +405 +00:33:23,640 --> 00:33:26,480 +اميوني اتصال اميوني اتصال اميوني اتصال اميوني + +406 +00:33:26,480 --> 00:33:29,400 +اتصال اميوني اتصال اميوني اتصال اميوني اتصال + +407 +00:33:29,400 --> 00:33:33,420 +اميوني اتصال اميوني اتصال اميوني اتصال اميوني + +408 +00:33:33,420 --> 00:33:42,780 +اتصال اميوني اتصال اميوني اتصال اميوني + +409 +00:33:42,780 --> 00:33:45,980 +اتصال اميوني + +410 +00:33:48,950 --> 00:33:52,450 +ولو كان في عندنا Dendritic Cell، الـ Dendritic + +411 +00:33:52,450 --> 00:33:56,690 +Cell ممكن تقدّم الـ Antigen لـ CD4 و أيضًا تعمل + +412 +00:33:56,690 --> 00:33:59,210 +Clonal Proliferation and Differentiation التي + +413 +00:33:59,210 --> 00:34:03,690 +نفسها أيضًا، لو في عندنا Dendritic Cell، ممكن + +414 +00:34:03,690 --> 00:34:08,770 +تقدّم الـ Antigen أيضًا لـ CD8 و CD8 يسلح Clonal + +415 +00:34:08,770 --> 00:34:12,510 +Proliferation and Differentiation طبعًا، من الواحد + +416 +00:34:12,510 --> 00:34:14,410 +و تلاتة، غالبًا + +417 +00:34:19,700 --> 00:34:24,260 +بتنشطوا بمساعدة الـ CD4 لأنه زي ما قلتلكوا الـ CD4 + +418 +00:34:24,260 --> 00:34:30,940 +هي من توزع الماء هذا ال life cycle تبعتنا وهنا + +419 +00:34:30,940 --> 00:34:32,920 +بنحكي على ال immune memory + +420 +00:34:38,210 --> 00:34:41,290 +انه في عندنا two response primary response و + +421 +00:34:41,290 --> 00:34:44,950 +secondary response في ال primary response او ال + +422 +00:34:44,950 --> 00:34:48,810 +acute infection بيكون في عندنا antibody من نوع IgM + +423 +00:34:48,810 --> 00:34:53,110 +في ال secondary response طبعا في هذه الحالة ال ال + +424 +00:34:53,110 --> 00:34:56,330 +ال ال immune response هو عبارة عن active immune + +425 +00:34:56,330 --> 00:35:01,920 +response acute immune response ماشيأول ما يخش الـ + +426 +00:35:01,920 --> 00:35:04,700 +Antigen على طول بيصير فيه اتنشر و بيطلع لنا + +427 +00:35:04,700 --> 00:35:09,460 +الخلايا IgM لكن لو قلنا بتطلع memory cell معاها + +428 +00:35:09,460 --> 00:35:12,980 +لكن لو دخل ال Antigen مرة تانية في ال secondary + +429 +00:35:12,980 --> 00:35:18,240 +immune response ممكن ال antibody اللي هو ال IgM + +430 +00:35:18,240 --> 00:35:22,100 +اللي طلع يتغير و يدينا أي نوع تاني من الاش من ال + +431 +00:35:22,100 --> 00:35:26,400 +antibody فممكن يطلعنا IgM و IgG و IgE او IgA + +432 +00:35:26,400 --> 00:35:31,340 +whateverحسب الـ Antigen specificity تبعته وهذا ما + +433 +00:35:31,340 --> 00:35:35,100 +يسمى بال class switching إيش يعني؟ يعني اختلف نوع + +434 +00:35:35,100 --> 00:35:40,320 +ال class من مينو جلوبلين ل class طبعا + +435 +00:35:40,320 --> 00:35:43,600 +بعد هيك وصفت لون ال expansion اللي هي ال B + +436 +00:35:43,600 --> 00:35:47,820 +lymphocytes صارت لون ال expansion واحدة صار في + +437 +00:35:47,820 --> 00:35:54,340 +أكتر من واحدة وطبعا صار في أنه ماتوريشن وطلعت أنه + +438 +00:35:56,890 --> 00:36:02,390 +بأول انفلاكيوتينفكشن لاش ننسى انه كمان + +439 +00:36:02,390 --> 00:36:05,310 +البيلينفوسايت بتلعب دور ك antigen presenting cell + +440 +00:36:05,310 --> 00:36:10,370 +هي البيلينفوسايت على سطحها ال antigen specific PCR + +441 +00:36:10,370 --> 00:36:15,730 +ماسك في ال antigen أخدته عملته processing و طلعته + +442 +00:36:15,730 --> 00:36:20,030 +مرتبة مين بال MSC molecule اللي على سطحها + +443 +00:36:23,350 --> 00:36:27,710 +تقدمه لمين التي البرسيل و بصير فيها ارتباطات + +444 +00:36:27,710 --> 00:36:30,810 +حناخدها ان شاء الله بالتفصيل و بعض الارتباطات بين + +445 +00:36:30,810 --> 00:36:34,310 +الخليتين بيصير فيه اللي هو cytokine release و ال + +446 +00:36:34,310 --> 00:36:42,110 +cytokine هو ما ينشط الخليتين نفس + +447 +00:36:42,110 --> 00:36:45,210 +الحكاية بيصير في ال CDA positive telephosite يوم + +448 +00:36:45,210 --> 00:36:51,180 +هتقدم لها الانتجين بعي class 1 MHC moleculeبتنشط و + +449 +00:36:51,180 --> 00:36:57,260 +بتطلع cytokine و ال cytokine هو اللي بنشط عملية + +450 +00:36:57,260 --> 00:37:04,580 +القطل لل ash لل antigen و هذا هي الاخر مرحلة ال + +451 +00:37:04,580 --> 00:37:08,300 +functional from the output from secondary lymphoid + +452 +00:37:08,300 --> 00:37:11,720 +organs اللي ممكن تطلع لنا plasma cell لتطلع ليها + +453 +00:37:11,720 --> 00:37:16,580 +antibody تطلع لنا memory cell بي memory cell اللي + +454 +00:37:16,580 --> 00:37:16,920 +ممكن + +455 +00:37:20,310 --> 00:37:23,210 +يعني يكون فيه specific response ل secondary + +456 +00:37:23,210 --> 00:37:26,190 +infection و أيضا ممكن يصير فيه اطلاع switching + +457 +00:37:26,190 --> 00:37:31,430 +فيها ممكن يطلع ان CD4 اللي بتلعب دور ك effector + +458 +00:37:31,430 --> 00:37:36,030 +cell او ممكن تنتقل على اي مرحلة من المراحل تشتر + +459 +00:37:36,030 --> 00:37:42,110 +خلايا اخرى او CD4 memory cell ثم CD8 reactive cell + +460 +00:37:42,110 --> 00:37:47,230 +و CD8 memory cell ال reactive بيسموها effector + +461 +00:37:47,230 --> 00:37:47,530 +cell + +462 +00:37:50,290 --> 00:37:55,690 +السؤال عن الـ Void ماذا يقول CD4 و CD8 يتم اختاره + +463 +00:37:55,690 --> 00:38:04,370 +من خلال عملية الانتجن الخاصة من خلال + +464 +00:38:04,370 --> 00:38:06,770 +عملية الانتجن الخاصة من خلال عملية الانتجن الخاصة + +465 +00:38:06,770 --> 00:38:08,850 +من خلال عملية الانتجن الخاصة من خلال عملية الانتجن + +466 +00:38:08,850 --> 00:38:10,750 +الخاصة من خلال عملية الانتجن الخاصة من خلال عملية + +467 +00:38:10,750 --> 00:38:12,170 +الانتجن الخاصة من خلال عملية الانتجن الخاصة من + +468 +00:38:12,170 --> 00:38:12,670 +خلال عملية الانتجن الخاصة من خلال عملية الانتجن + +469 +00:38:12,670 --> 00:38:14,910 +الخاصة من خلال عملية الانتجن الخاصة من خلال عملية + +470 +00:38:14,910 --> 00:38:16,270 +الانتجن الخاصة من خلال عملية الانتجن الخاصة من + +471 +00:38:16,270 --> 00:38:16,350 +خلال + +472 +00:38:19,610 --> 00:38:24,930 +الثايمس at the end of their maturation نحكي على + +473 +00:38:24,930 --> 00:38:30,550 +CD4 و CD8 يعني T-lymphocyte و T-lymphocyte بتنضج + +474 +00:38:30,550 --> 00:38:36,210 +في الثايمس و بتتم عملية تعليمها في الثايمس و بتفرق + +475 +00:38:36,210 --> 00:38:39,390 +بين ال self و ال non self في الثايمس وبالتالي + +476 +00:38:39,390 --> 00:38:40,890 +الإجابة هتكون C + +477 +00:38:45,200 --> 00:38:50,360 +ماشي طيب نجم نتقل الى موضوع اخر ان كيف تتعرف هذه + +478 +00:38:50,360 --> 00:38:55,260 +الخلايا المناعية على ال antigen تبعها و كيف تتنشط + +479 +00:38:55,260 --> 00:38:59,020 +كيف تتعرف ان هذا ال antigen تبعها ولا لا قالوا + +480 +00:38:59,020 --> 00:39:01,960 +they have receptors على سطح هذه الخلايا they have + +481 +00:39:01,960 --> 00:39:05,700 +receptors for or express chemokine + +482 +00:39:09,130 --> 00:39:11,770 +أيضًا express sell additional fuel integrated + +483 +00:39:11,770 --> 00:39:18,310 +selected these collectively جاعد جاعد يعني متوجه + +484 +00:39:18,310 --> 00:39:26,010 +these cells where they should go كلهم بيسموهم + +485 +00:39:26,010 --> 00:39:29,150 +addressing شو بيسموهم addressing يبقى فيه على سطح + +486 +00:39:29,150 --> 00:39:35,630 +الخلايا موجود عدة عوامل عدة عواملمن ضمنها سلعة + +487 +00:39:35,630 --> 00:39:38,830 +ديجاموريكول زي الـ Integrin و الـ Selectin من + +488 +00:39:38,830 --> 00:39:44,450 +ضمنها secretion of certain receptors أو في + +489 +00:39:44,450 --> 00:39:49,330 +cytokine receptors كل هما دولة ممكن يشتغلنا اللي + +490 +00:39:49,330 --> 00:39:53,010 +هو أو يوجهوا الخلية وين تروح طبعا هذه الصور زي ما + +491 +00:39:53,010 --> 00:39:57,090 +انتوا شايفين هذه الخلايا على سطحها إيش receptors + +492 +00:39:57,090 --> 00:40:01,670 +وهذا مثال by cytokine IL-2 cytokines لما ان الخلية + +493 +00:40:01,670 --> 00:40:05,960 +activated من resting لactivatedوها دي في A هنا + +494 +00:40:05,960 --> 00:40:09,020 +أنواع ال cell adhesion molecule هنا دي عبارة عن + +495 +00:40:09,020 --> 00:40:15,000 +cell adhesion molecule family أربع أنواع وهى دور + +496 +00:40:15,000 --> 00:40:19,680 +ال address اللى توسمناها داشي B lymphocyte او T + +497 +00:40:19,680 --> 00:40:24,640 +lymphocyte نايف قولنا ماشفتش أنت جنجبل هيك ومن ده + +498 +00:40:24,640 --> 00:40:28,520 +تتوجه يعني بتلعب على spleen او lymph nodes يجي + +499 +00:40:28,520 --> 00:40:33,920 +بتدور على مين ده spleen او lymph nodesده دلوني على + +500 +00:40:33,920 --> 00:40:35,220 +وين؟ على نسبين + +501 +00:40:38,550 --> 00:40:42,390 +الـ cells هو اللي بيمسكها و بيتعرف عليها و بيقعدها + +502 +00:40:42,390 --> 00:40:46,530 +في الـ spleen أو ال lymph nodes طبعا نفس الحكاية + +503 +00:40:46,530 --> 00:40:50,030 +بتنطمق على مين؟ على ال T cell أو ال T helper cell + +504 +00:40:50,030 --> 00:40:55,650 +برضه بتتاخد لكن بدها مساعد، إيش المساعد؟ antigen + +505 +00:40:55,650 --> 00:40:58,630 +presenting cell و ال antigen presenting cell هنا + +506 +00:40:58,630 --> 00:41:01,830 +مرة ضربين مثال على ال dendritic cell و مرة ضربين + +507 +00:41:01,830 --> 00:41:05,630 +مثال على ال B lymphocyte كantigen presenting cell + +508 +00:41:07,020 --> 00:41:12,560 +هذه حدوثة كبيرة مثال حي على دور الأدرسين وهي عملية + +509 +00:41:12,560 --> 00:41:18,960 +الفاجو سايتوسس عملية إيش؟ الفاجو سايتوسس كب التم + +510 +00:41:18,960 --> 00:41:24,460 +جالوا يوم ما يصير فيه أنتجم ماشي؟الـ Antigen بيخش + +511 +00:41:24,460 --> 00:41:29,980 +على الـ Extra Cellular Tissue برا لكن في كل نسيج + +512 +00:41:29,980 --> 00:41:34,760 +فيه blood supply فهي ال blood vessels ده هو + +513 +00:41:34,760 --> 00:41:39,100 +المتمثل و ال blood vessels في جلبه خلايا كيف + +514 +00:41:39,100 --> 00:41:42,860 +الخلايا المنعية؟ بدها تطلع من ال blood vessels و + +515 +00:41:42,860 --> 00:41:46,680 +تروح على ال Antigen اللي موجود برا ال blood + +516 +00:41:46,680 --> 00:41:51,150 +vessels في ال tissueقالوا بتمر هذه العملية في عدة + +517 +00:41:51,150 --> 00:41:57,510 +مراحل أساسية هو المرحلة ده هي بيسموها ال + +518 +00:41:57,510 --> 00:42:01,290 +activation captain قالوا والله بيصير في expression + +519 +00:42:01,290 --> 00:42:06,710 +for cell surface molecule وينموجود على ال vascular + +520 +00:42:06,710 --> 00:42:12,170 +membrane تبع ال blood vessels طب كيش اللي نشطه؟ + +521 +00:42:12,170 --> 00:42:17,510 +قالوا هيوغانة tissue damage ايه شايمين؟ قال نشط ال + +522 +00:42:18,370 --> 00:42:24,310 +Indothelial cells عمللها damage و ال damage طلعت + +523 +00:42:24,310 --> 00:42:29,940 +براديكا انينوفابرينوبيتايد اكت موليكولأيضا نشطة ال + +524 +00:42:29,940 --> 00:42:34,820 +compliment ودول collectively اسمهم إيش؟ اسمهم + +525 +00:42:34,820 --> 00:42:38,900 +addressing فبيضلوا يسبحوا يسبحوا يسبحوا لغاية ما + +526 +00:42:38,900 --> 00:42:42,560 +يصلوا أقرب blood vessels و هناك بنشطوا .. بيخشوا + +527 +00:42:42,560 --> 00:42:45,900 +فبنشطوا الخلايا و الخلايا بتمسك في receptor على + +528 +00:42:45,900 --> 00:42:49,340 +سطح ال blood vessels متى ما انمسك ال receptors بال + +529 +00:42:49,340 --> 00:42:54,580 +blood vessels ماشي بصير في activation للخلايا + +530 +00:42:54,580 --> 00:43:00,020 +فبتروحوا هي عاملةعاملة releasing a certain + +531 +00:43:00,020 --> 00:43:03,580 +cytokine or interleukin mainly آية التمانية اللي + +532 +00:43:03,580 --> 00:43:07,540 +بيعمل vasodilatation وإذا صار فيه vasodilatation + +533 +00:43:07,540 --> 00:43:12,520 +يعني تباعدة الخلايا المبطنة للوعاء الدموي عن بعضها + +534 +00:43:12,520 --> 00:43:17,800 +مما يسمح بخروج الخلايا من داخل وعاء الدموي إلى + +535 +00:43:17,800 --> 00:43:23,080 +خارجه يسمون هذه العملية diabetes انزلاق الخلايا + +536 +00:43:23,080 --> 00:43:27,910 +فبتروحتطلع طلعت من ال blood vessel و طلعت برا لما + +537 +00:43:27,910 --> 00:43:31,350 +تطلع برا بصير في مرحلة تانية بيسموها ال chemotaxis + +538 +00:43:31,350 --> 00:43:35,890 +شو بيسموها ال chemotaxis اللي هو حركة الموجهة لمين + +539 +00:43:35,890 --> 00:43:40,390 +لهذه الخلايا و اين بتروح يعني و بتدل ماشية ورا مين + +540 +00:43:40,390 --> 00:43:43,090 +ورا ال addressing's ما احنا قولنا ال addressing's + +541 +00:43:43,090 --> 00:43:46,490 +هذه اللي اتنشطت من البداية دلت تسبح لغاية ما وصلت + +542 +00:43:46,490 --> 00:43:51,850 +مين وصلت الوعي الدمام فبتمشي وراها و طبعا يا بنات + +543 +00:43:51,850 --> 00:44:00,090 +و يا شباب كل مابعدنا عن ال site of infection كل ما + +544 +00:44:00,090 --> 00:44:04,870 +تركيز هذه المواد قلب وكل ما جربنا كل ما تركيز هذه + +545 +00:44:04,870 --> 00:44:09,890 +المواد زاد وبالتالي بتضال ماشية حسب التركيز يعني + +546 +00:44:09,890 --> 00:44:13,730 +تتحسس ال concentration gradient زيادة increase in + +547 +00:44:13,730 --> 00:44:17,930 +concentration gradient ماشي زيادة تركيز هذه المواد + +548 +00:44:17,930 --> 00:44:20,930 +بتضال ماشية ماشية ماشية لغاية ما تصل لمين لل + +549 +00:44:20,930 --> 00:44:26,000 +antigen و هناك مالهاش عينين تشوفوالكن بيكون على + +550 +00:44:26,000 --> 00:44:31,520 +سطح ال antigen علامات + +551 +00:44:31,520 --> 00:44:34,760 +ايش العلامات اللي على سطح ال antigen بحنا قولنا ان + +552 +00:44:34,760 --> 00:44:41,640 +ال compliment compliment بتتنشف فبتكون قاعدة و على + +553 +00:44:41,640 --> 00:44:45,870 +سطح ال antigen و برضه بيكون في immunoglobulinبرضه + +554 +00:44:45,870 --> 00:44:49,430 +سابق و جاعد على سطح ال antigen لإنه بيعلموا .. + +555 +00:44:49,430 --> 00:44:52,130 +أدولة بيعلموا ال antigen ال complement و ال + +556 +00:44:52,130 --> 00:44:54,390 +immunoglobulin اللي جاعدين على سطح ال antigen اللي + +557 +00:44:54,390 --> 00:44:57,510 +لهم receptor على سطح الخلايا فبتمشيك الخلايا بال + +558 +00:44:57,510 --> 00:45:01,830 +receptor أو الخلية من خلال ال receptor تبلي على + +559 +00:45:01,830 --> 00:45:05,050 +سطحها تمشيك في ال antigen و تعمل عملية قاتلة لهذا + +560 +00:45:05,050 --> 00:45:08,610 +ال antigen يبقى هذا مثال حي عن دور ال addressing + +561 +00:45:08,610 --> 00:45:15,730 +لمين ل .. في الفيربوسيتوسطبعاً هنا effect of + +562 +00:45:15,730 --> 00:45:20,710 +dealing for scienceبينلي سودو إلكترونية by + +563 +00:45:20,710 --> 00:45:27,810 +electron microscope كانت الخلية ماشية اللي هو غير + +564 +00:45:27,810 --> 00:45:31,250 +ناشطة و لما اتنشطت طلعتلي اللي الـ B lymphocyte + +565 +00:45:31,250 --> 00:45:36,770 +طلعتلي مين؟ طلعتلي ال antibody منoglobulin فسبقوها + +566 +00:45:36,770 --> 00:45:39,130 +..سبقوا المنoglobulin سبقات مختلفة ال fluorescent + +567 +00:45:39,130 --> 00:45:42,610 +dye و ال fluorescent dye بدأو بينلي مرة في ال bone + +568 +00:45:42,610 --> 00:45:49,860 +مرة في ال lymph nodesدليل عليها ناشطة طيب، كيف + +569 +00:45:49,860 --> 00:45:53,600 +تقتل الـ cytotoxic T lymphocyte؟ كانوا بتمر في عدة + +570 +00:45:53,600 --> 00:45:58,660 +مراحل، يوم تتنشط تدهيب، بتقدملها الانتجين من خلال + +571 +00:45:58,660 --> 00:46:02,060 +target تتحسس الانتجين الموجود في target cell لأنه + +572 +00:46:02,060 --> 00:46:05,700 +هي بتقتل الـ intracellular antigen، فبتتحسسه، تروح + +573 +00:46:05,700 --> 00:46:09,720 +و هي مرتبطة في خلية الـ cytotoxic مرتبطة فيها + +574 +00:46:09,720 --> 00:46:14,530 +الخلية اللي في جلبها الانتجينوبتعمل حاجة بيسموها + +575 +00:46:14,530 --> 00:46:18,150 +«cytoplasmic rearrangement» محتوية الـ + +576 +00:46:18,150 --> 00:46:22,170 +«cytoplasmic» كلها بتتركز في منطقة المسك تتركز، + +577 +00:46:22,170 --> 00:46:27,090 +فده هي، في منطقة ليش؟ المسك وبعد هيك بتعمل + +578 +00:46:27,090 --> 00:46:30,790 +«exocytosis» بتعمل مفرزة كل اللي هو ال + +579 +00:46:30,790 --> 00:46:34,410 +«cytoplasmic» molecule اللي موجود في داخلها، وده + +580 +00:46:34,410 --> 00:46:40,720 +جالباًفيها إنزايم بعمل عملية قتل أو دوبان لل cell + +581 +00:46:40,720 --> 00:46:46,040 +membrane تبع الخلية المشابه ومتمدأ بال cell + +582 +00:46:46,040 --> 00:46:49,000 +membrane يعني الفتح صار في فتحه وإذا صار في فتحه + +583 +00:46:49,000 --> 00:46:53,840 +دخلت الميه وإذا دخلت الميه قتلتها أول ما تسيل + +584 +00:46:53,840 --> 00:46:58,840 +الفتحه بتسيب cytotoxic telephosphate الخلية + +585 +00:46:58,840 --> 00:47:05,850 +المشابه وبتروح تمسك غيرها وبتروح تمسك أيش غيرهاهذه + +586 +00:47:05,850 --> 00:47:11,570 +الصورة بتبين لي مراكز اللي هو تركيز الانتجن أو + +587 +00:47:11,570 --> 00:47:14,530 +عملية قتل الانتجن في its secondary lymphoid organs + +588 +00:47:14,530 --> 00:47:21,030 +بالنسبة المختلفة هذه الصورة بتبين لي كيف تنشط ال + +589 +00:47:21,030 --> 00:47:27,370 +CD4 الماكروفاج، هذه هي ال CD4 حولت ال resting + +590 +00:47:27,370 --> 00:47:30,790 +macrophage لمين؟ ل activated macrophage + +591 +00:47:34,940 --> 00:47:41,600 +يعني أتمنى أنه أكون قد لميت الموضوع المناعي بشكل + +592 +00:47:41,600 --> 00:47:47,760 +عام من خلال هذه المحاضرة وإن شاء الله في محاضرات + +593 +00:47:47,760 --> 00:47:54,980 +قادمة هنبدأ نفصل كل مصطلح مناعي مارينا فيه من خلال + +594 +00:47:54,980 --> 00:47:58,340 +هذه المحاضرة إضافة هذه النقطة النقطة التانية إن + +595 +00:47:58,340 --> 00:48:01,260 +شاء الله هنبدأ نفصل أنواع المناعة كلها على حدة + diff --git a/PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/-KFnjmJFb28_raw.json b/PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/-KFnjmJFb28_raw.json new file mode 100644 index 0000000000000000000000000000000000000000..8dd8473293e45ba4a6e6122fcd432c58a5fa02fa --- /dev/null +++ b/PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/-KFnjmJFb28_raw.json @@ -0,0 +1 @@ +{"segments": [{"id": 1, "seek": 4834, "start": 20.96, "end": 48.34, "text": " Okay. Good morning to you again. How are you? Good. It's nice to start with a smile. Now look, expressions of quantity. Some of expresses what? Quantity, right? A lot of expresses quantity. Two thirds of. Most of. They express what? They express quantity. Okay. Now these expressions of quantity.", "tokens": [1033, 13, 2205, 2446, 281, 291, 797, 13, 1012, 366, 291, 30, 2205, 13, 467, 311, 1481, 281, 722, 365, 257, 7563, 13, 823, 574, 11, 15277, 295, 11275, 13, 2188, 295, 39204, 437, 30, 26968, 507, 11, 558, 30, 316, 688, 295, 39204, 11275, 13, 4453, 34552, 295, 13, 4534, 295, 13, 814, 5109, 437, 30, 814, 5109, 11275, 13, 1033, 13, 823, 613, 15277, 295, 11275, 13], "avg_logprob": -0.1898437506386212, "compression_ratio": 1.736842105263158, "no_speech_prob": 0.0, "words": [{"start": 20.96, "end": 21.3, "word": " Okay.", "probability": 0.74462890625}, {"start": 21.34, "end": 21.5, "word": " Good", "probability": 0.8642578125}, {"start": 21.5, "end": 21.74, "word": " morning", "probability": 0.892578125}, {"start": 21.74, "end": 21.96, "word": " to", "probability": 0.95849609375}, {"start": 21.96, "end": 22.1, "word": " you", "probability": 0.96484375}, {"start": 22.1, "end": 22.5, "word": " again.", "probability": 0.9423828125}, {"start": 23.2, "end": 23.88, "word": " How", "probability": 0.72998046875}, {"start": 23.88, "end": 24.08, "word": " are", "probability": 0.94970703125}, {"start": 24.08, "end": 24.32, "word": " you?", "probability": 0.96875}, {"start": 24.74, "end": 25.42, "word": " Good.", "probability": 0.85400390625}, {"start": 25.52, "end": 25.74, "word": " It's", "probability": 0.962646484375}, {"start": 25.74, "end": 26.0, "word": " nice", "probability": 0.90771484375}, {"start": 26.0, "end": 26.18, "word": " to", "probability": 0.95751953125}, {"start": 26.18, "end": 26.5, "word": " start", "probability": 0.92724609375}, {"start": 26.5, "end": 26.66, "word": " with", "probability": 0.892578125}, {"start": 26.66, "end": 26.8, "word": " a", "probability": 0.99560546875}, {"start": 26.8, "end": 27.14, "word": " smile.", "probability": 0.9345703125}, {"start": 28.32, "end": 28.58, "word": " Now", "probability": 0.91845703125}, {"start": 28.58, "end": 29.22, "word": " look,", "probability": 0.705078125}, {"start": 29.94, "end": 30.48, "word": " expressions", "probability": 0.68115234375}, {"start": 30.48, "end": 30.88, "word": " of", "probability": 0.9541015625}, {"start": 30.88, "end": 31.52, "word": " quantity.", "probability": 0.8154296875}, {"start": 32.06, "end": 32.32, "word": " Some", "probability": 0.68505859375}, {"start": 32.32, "end": 32.6, "word": " of", "probability": 0.9326171875}, {"start": 32.6, "end": 33.32, "word": " expresses", "probability": 0.59033203125}, {"start": 33.32, "end": 33.8, "word": " what?", "probability": 0.74365234375}, {"start": 34.52, "end": 35.2, "word": " Quantity,", "probability": 0.910888671875}, {"start": 35.46, "end": 35.72, "word": " right?", "probability": 0.89794921875}, {"start": 36.34, "end": 36.58, "word": " A", "probability": 0.85302734375}, {"start": 36.58, "end": 36.82, "word": " lot", "probability": 0.95458984375}, {"start": 36.82, "end": 37.14, "word": " of", "probability": 0.96923828125}, {"start": 37.14, "end": 37.74, "word": " expresses", "probability": 0.83203125}, {"start": 37.74, "end": 39.08, "word": " quantity.", "probability": 0.96630859375}, {"start": 39.24, "end": 39.42, "word": " Two", "probability": 0.75341796875}, {"start": 39.42, "end": 39.84, "word": " thirds", "probability": 0.70849609375}, {"start": 39.84, "end": 40.22, "word": " of.", "probability": 0.96728515625}, {"start": 40.76, "end": 41.2, "word": " Most", "probability": 0.875}, {"start": 41.2, "end": 41.64, "word": " of.", "probability": 0.97021484375}, {"start": 41.84, "end": 41.98, "word": " They", "probability": 0.8076171875}, {"start": 41.98, "end": 42.36, "word": " express", "probability": 0.86767578125}, {"start": 42.36, "end": 42.82, "word": " what?", "probability": 0.8720703125}, {"start": 43.44, "end": 43.66, "word": " They", "probability": 0.751953125}, {"start": 43.66, "end": 44.12, "word": " express", "probability": 0.87109375}, {"start": 44.12, "end": 44.8, "word": " quantity.", "probability": 0.9560546875}, {"start": 45.1, "end": 45.28, "word": " Okay.", "probability": 0.796875}, {"start": 45.52, "end": 46.16, "word": " Now", "probability": 0.95458984375}, {"start": 46.16, "end": 46.7, "word": " these", "probability": 0.5859375}, {"start": 46.7, "end": 47.28, "word": " expressions", "probability": 0.921875}, {"start": 47.28, "end": 47.68, "word": " of", "probability": 0.9677734375}, {"start": 47.68, "end": 48.34, "word": " quantity.", "probability": 0.96240234375}], "temperature": 1.0}, {"id": 2, "seek": 6715, "start": 49.27, "end": 67.15, "text": " Don't determine what type of verb should be used after them. Now listen, it is singular if you have a singular noun. Look at book, it is singular. Equipment? 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Okay, now we used a singular noun and a singular verb. Now look, the same amounts, the same words, the same expressions, some of, a lot of, and so on. What did we use after them? Plural nouns. Plural nouns, good. And after the plural nouns? Plural verbs. Okay, good. 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What do you understand? Yes, Marwa. With expressions of quantity, we use the singular verbs when we use singular nouns. Good. But use plural verbs when we use plural nouns.", "tokens": [2102, 393, 980, 385, 30, 708, 360, 291, 1223, 30, 1079, 11, 2039, 4151, 13, 2022, 15277, 295, 11275, 11, 321, 764, 264, 20010, 30051, 562, 321, 764, 20010, 48184, 13, 2205, 13, 583, 764, 25377, 30051, 562, 321, 764, 25377, 48184, 13], "avg_logprob": -0.3212002807042815, "compression_ratio": 1.4728682170542635, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 91.98, "end": 92.24, "word": " Who", "probability": 0.51611328125}, {"start": 92.24, "end": 92.52, "word": " can", "probability": 0.6865234375}, {"start": 92.52, "end": 92.74, "word": " tell", "probability": 0.413330078125}, {"start": 92.74, "end": 93.0, "word": " me?", "probability": 0.96630859375}, {"start": 93.3, "end": 93.48, "word": " What", "probability": 0.833984375}, {"start": 93.48, "end": 93.58, "word": " do", "probability": 0.9462890625}, {"start": 93.58, "end": 93.68, "word": " you", "probability": 0.96630859375}, {"start": 93.68, "end": 94.3, "word": " understand?", "probability": 0.8232421875}, {"start": 94.9, "end": 95.18, "word": " Yes,", "probability": 0.85546875}, {"start": 95.38, "end": 95.72, "word": " Marwa.", "probability": 0.879638671875}, {"start": 95.94, "end": 96.08, "word": " With", "probability": 0.48388671875}, {"start": 96.08, "end": 96.66, "word": " expressions", "probability": 0.552734375}, {"start": 96.66, "end": 96.94, "word": " of", "probability": 0.89599609375}, {"start": 96.94, "end": 97.5, "word": " quantity,", "probability": 0.8369140625}, {"start": 98.2, "end": 98.32, "word": " we", "probability": 0.88916015625}, {"start": 98.32, "end": 99.64, "word": " use", "probability": 0.8173828125}, {"start": 99.64, "end": 99.82, "word": " the", "probability": 0.59326171875}, {"start": 99.82, "end": 100.68, "word": " singular", "probability": 0.89794921875}, {"start": 100.68, "end": 101.14, "word": " verbs", "probability": 0.68896484375}, {"start": 101.14, "end": 101.38, "word": " when", "probability": 0.77734375}, {"start": 101.38, "end": 101.56, "word": " we", "probability": 0.94873046875}, {"start": 101.56, "end": 101.9, "word": " use", "probability": 0.89306640625}, {"start": 101.9, "end": 103.64, "word": " singular", "probability": 0.54833984375}, {"start": 103.64, "end": 104.0, "word": " nouns.", "probability": 0.55126953125}, {"start": 104.12, "end": 104.3, "word": " Good.", "probability": 0.701171875}, {"start": 104.36, "end": 104.62, "word": " But", "probability": 0.8349609375}, {"start": 104.62, "end": 104.92, "word": " use", "probability": 0.400390625}, {"start": 104.92, "end": 105.24, "word": " plural", "probability": 0.9501953125}, {"start": 105.24, "end": 105.64, "word": " verbs", "probability": 0.80126953125}, {"start": 105.64, "end": 106.04, "word": " when", "probability": 0.79736328125}, {"start": 106.04, "end": 106.28, "word": " we", "probability": 0.93408203125}, {"start": 106.28, "end": 106.64, "word": " use", "probability": 0.89990234375}, {"start": 106.64, "end": 107.1, "word": " plural", "probability": 0.86181640625}, {"start": 107.1, "end": 107.14, "word": " nouns.", "probability": 0.63720703125}], "temperature": 1.0}, {"id": 5, "seek": 13294, "start": 107.24, "end": 132.94, "text": " Thank you very much. So with expressions of a quantity, we can use plural and singular. If a plural noun is used, we use a plural verb. Singular, we need what? Singular. Okay, read please. In most expressions of quantity, the verb is determined by the noun or pronoun that I follow. For example,", "tokens": [1044, 291, 588, 709, 13, 407, 365, 15277, 295, 257, 11275, 11, 321, 393, 764, 25377, 293, 20010, 13, 759, 257, 25377, 23307, 307, 1143, 11, 321, 764, 257, 25377, 9595, 13, 7474, 1040, 11, 321, 643, 437, 30, 7474, 1040, 13, 1033, 11, 1401, 1767, 13, 682, 881, 15277, 295, 11275, 11, 264, 9595, 307, 9540, 538, 264, 23307, 420, 14144, 300, 286, 1524, 13, 1171, 1365, 11], "avg_logprob": -0.18794643517051424, "compression_ratio": 1.6174863387978142, "no_speech_prob": 0.0, "words": [{"start": 107.24, "end": 107.54, "word": " Thank", "probability": 0.626953125}, {"start": 107.54, "end": 107.68, "word": " you", "probability": 0.96044921875}, {"start": 107.68, "end": 107.88, "word": " very", "probability": 0.8447265625}, {"start": 107.88, "end": 108.2, "word": " much.", "probability": 0.9150390625}, {"start": 108.36, "end": 108.48, "word": " So", "probability": 0.87353515625}, {"start": 108.48, "end": 108.7, "word": " with", "probability": 0.767578125}, {"start": 108.7, "end": 109.2, "word": " expressions", "probability": 0.8125}, {"start": 109.2, "end": 109.54, "word": " of", "probability": 0.96826171875}, {"start": 109.54, "end": 109.66, "word": " a", "probability": 0.62890625}, {"start": 109.66, "end": 110.1, "word": " quantity,", "probability": 0.978515625}, {"start": 110.38, "end": 110.74, "word": " we", "probability": 0.95703125}, {"start": 110.74, "end": 111.02, "word": " can", "probability": 0.94384765625}, {"start": 111.02, "end": 111.32, "word": " use", "probability": 0.896484375}, {"start": 111.32, "end": 111.74, "word": " plural", "probability": 0.96533203125}, {"start": 111.74, "end": 112.12, "word": " and", "probability": 0.94384765625}, {"start": 112.12, "end": 112.54, "word": " singular.", "probability": 0.98486328125}, {"start": 112.86, "end": 113.54, "word": " If", "probability": 0.923828125}, {"start": 113.54, "end": 113.9, "word": " a", "probability": 0.994140625}, {"start": 113.9, "end": 114.22, "word": " plural", "probability": 0.97802734375}, {"start": 114.22, "end": 114.58, "word": " noun", "probability": 0.9677734375}, {"start": 114.58, "end": 114.84, "word": " is", "probability": 0.95068359375}, {"start": 114.84, "end": 115.28, "word": " used,", "probability": 0.92626953125}, {"start": 115.54, "end": 115.64, "word": " we", "probability": 0.95751953125}, {"start": 115.64, "end": 116.02, "word": " use", "probability": 0.87548828125}, {"start": 116.02, "end": 116.22, "word": " a", "probability": 0.99072265625}, {"start": 116.22, "end": 116.52, "word": " plural", "probability": 0.98046875}, {"start": 116.52, "end": 116.9, "word": " verb.", "probability": 0.845703125}, {"start": 117.36, "end": 117.88, "word": " Singular,", "probability": 0.94921875}, {"start": 118.2, "end": 118.34, "word": " we", "probability": 0.93115234375}, {"start": 118.34, "end": 118.72, "word": " need", "probability": 0.9248046875}, {"start": 118.72, "end": 118.96, "word": " what?", "probability": 0.4189453125}, {"start": 119.26, "end": 119.92, "word": " Singular.", "probability": 0.920166015625}, {"start": 120.32, "end": 120.56, "word": " Okay,", "probability": 0.76318359375}, {"start": 121.04, "end": 121.32, "word": " read", "probability": 0.93359375}, {"start": 121.32, "end": 121.8, "word": " please.", "probability": 0.68408203125}, {"start": 122.54, "end": 122.72, "word": " In", "probability": 0.5673828125}, {"start": 122.72, "end": 122.98, "word": " most", "probability": 0.8984375}, {"start": 122.98, "end": 123.62, "word": " expressions", "probability": 0.93212890625}, {"start": 123.62, "end": 124.06, "word": " of", "probability": 0.93212890625}, {"start": 124.06, "end": 124.6, "word": " quantity,", "probability": 0.90673828125}, {"start": 124.88, "end": 124.88, "word": " the", "probability": 0.8974609375}, {"start": 124.88, "end": 125.18, "word": " verb", "probability": 0.80859375}, {"start": 125.18, "end": 125.44, "word": " is", "probability": 0.91552734375}, {"start": 125.44, "end": 127.68, "word": " determined", "probability": 0.9189453125}, {"start": 127.68, "end": 128.52, "word": " by", "probability": 0.8427734375}, {"start": 128.52, "end": 128.78, "word": " the", "probability": 0.87451171875}, {"start": 128.78, "end": 129.1, "word": " noun", "probability": 0.951171875}, {"start": 129.1, "end": 129.76, "word": " or", "probability": 0.72265625}, {"start": 129.76, "end": 130.36, "word": " pronoun", "probability": 0.55224609375}, {"start": 130.36, "end": 130.84, "word": " that", "probability": 0.86474609375}, {"start": 130.84, "end": 131.08, "word": " I", "probability": 0.33447265625}, {"start": 131.08, "end": 131.54, "word": " follow.", "probability": 0.896484375}, {"start": 131.98, "end": 132.36, "word": " For", "probability": 0.8740234375}, {"start": 132.36, "end": 132.94, "word": " example,", "probability": 0.9697265625}], "temperature": 1.0}, {"id": 6, "seek": 16341, "start": 142.16, "end": 163.42, "text": " Okay, thank you. Now look, one of my friends, one of my friends, each of my friends, do you remember when we talked about each? Okay, now, yeah, each,", "tokens": [1033, 11, 1309, 291, 13, 823, 574, 11, 472, 295, 452, 1855, 11, 472, 295, 452, 1855, 11, 1184, 295, 452, 1855, 11, 360, 291, 1604, 562, 321, 2825, 466, 1184, 30, 1033, 11, 586, 11, 1338, 11, 1184, 11], "avg_logprob": -0.2772484756097561, "compression_ratio": 1.4803921568627452, "no_speech_prob": 0.0, "words": [{"start": 142.16000000000003, "end": 143.20000000000002, "word": " Okay,", "probability": 0.0716552734375}, {"start": 143.20000000000002, "end": 144.24, "word": " thank", "probability": 0.791015625}, {"start": 144.24, "end": 144.5, "word": " you.", "probability": 0.96630859375}, {"start": 145.06, "end": 145.38, "word": " Now", "probability": 0.94677734375}, {"start": 145.38, "end": 145.98, "word": " look,", "probability": 0.5791015625}, {"start": 147.14, "end": 147.46, "word": " one", "probability": 0.91552734375}, {"start": 147.46, "end": 147.84, "word": " of", "probability": 0.97314453125}, {"start": 147.84, "end": 148.12, "word": " my", "probability": 0.97314453125}, {"start": 148.12, "end": 148.68, "word": " friends,", "probability": 0.814453125}, {"start": 149.52, "end": 150.32, "word": " one", "probability": 0.7861328125}, {"start": 150.32, "end": 151.16, "word": " of", "probability": 0.97119140625}, {"start": 151.16, "end": 151.48, "word": " my", "probability": 0.97119140625}, {"start": 151.48, "end": 152.06, "word": " friends,", "probability": 0.78173828125}, {"start": 153.24, "end": 153.56, "word": " each", "probability": 0.95947265625}, {"start": 153.56, "end": 153.9, "word": " of", "probability": 0.970703125}, {"start": 153.9, "end": 154.22, "word": " my", "probability": 0.97021484375}, {"start": 154.22, "end": 154.78, "word": " friends,", "probability": 0.78662109375}, {"start": 155.08, "end": 155.78, "word": " do", "probability": 0.9375}, {"start": 155.78, "end": 155.96, "word": " you", "probability": 0.96533203125}, {"start": 155.96, "end": 156.48, "word": " remember", "probability": 0.88330078125}, {"start": 156.48, "end": 157.42, "word": " when", "probability": 0.89111328125}, {"start": 157.42, "end": 157.64, "word": " we", "probability": 0.96630859375}, {"start": 157.64, "end": 157.98, "word": " talked", "probability": 0.8857421875}, {"start": 157.98, "end": 158.4, "word": " about", "probability": 0.90576171875}, {"start": 158.4, "end": 158.84, "word": " each?", "probability": 0.95556640625}, {"start": 159.38, "end": 160.1, "word": " Okay,", "probability": 0.55224609375}, {"start": 160.62, "end": 161.26, "word": " now,", "probability": 0.90771484375}, {"start": 161.32, "end": 162.42, "word": " yeah,", "probability": 0.80029296875}, {"start": 162.82, "end": 163.42, "word": " each,", "probability": 0.953125}], "temperature": 1.0}, {"id": 7, "seek": 18911, "start": 169.07, "end": 189.11, "text": " Student has. Okay? Each student has. Every student has. Now, if I say each of students. 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Now, one of my friends is, this is what? Plural. And this is? Singular. Okay. My, each of my friends, plural and singular. Every one of my friends. Okay. Now look, this is singular and this is plural. 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The general rule of subject-verb agreement. 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Okay. Plural with a plural and singular with singular. Now, what about this? What can you see? This is singular and this is plural. This is what? Singular and plural. And this is what? Okay. And this is what? This is an exception. Okay. This is an exception. 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One of each of and every one of are followed by plural nouns and take singular verbs. Thank you very much. This is an exception to the rule, okay? Any question? Now, none of the boys is here. 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Subject with none of used to be considered singular. This is in the past. They used it in the past. Now it is not used. Used to be. 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Okay. This is the total number. Okay. The total number. 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We are talking about today, how many students? One, two, it is about 65. We have 65 out of 70. Okay, so the number of students is. What does that mean? 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The number of students in the class is 15. Yeah, the number is 15. Now this is what? This is the subject. Good, go on. A number of students were late for class. 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A lot of students are. So we have two expressions. The number of students is. A number of students are. And you know, as you see, this is followed by plural noun, and this is followed by what? Plural noun. Now please look at your books. Exercise 11. 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Very good. Thank you very much. Next one. Yes, please. Number three. Most of the movie is funny. Most of the movie is. Good. Thank you. Next one. Most of the movies are funny. Thank you very much. Good. Next one. 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One is, okay, thank you. Yes, Noor? Each boy in the class has his own number. Each boy has, very good, thank you. Yes, please, yeah? Each of the boys in the class has his own number. Which one you are doing? 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Okay, each of the boys has. Thank you. Twelve. Yes, please. Okay, thank you. Every one of the students is. Yes, please. None of the animals are. 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So none of the animals are free. All of them are. Okay, thank you. Yes, please. A number of students are absent today. A number are. Good, thank you. Yes. The number of employees in my company is. Is. The number is. Thank you very much. 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Why was one of the students okay now look What about there? What do you have in your bag Marwa? There is a sandwich in her bag There are some box in her bag Okay What do you have in your bag Khadija? 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There is a grammar book. Okay. And thank you. Yeah. What do you have in your bag, please? There is a wallet. Good. What do you have in your bag, please? There, there, there. Start with there. 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There is a mobile. Thank you very much. Yes, what do you have in your bag? There is some money. Thank you. Yes, what do you have in your bag? There is a piece of chocolate. Thank you. Good. 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Thank you very much. Now look, there is a fly. This is singular and this is singular. There are three windows. Now, R can be followed by?", "tokens": [821, 366, 257, 688, 295, 721, 13, 1044, 291, 588, 709, 13, 823, 574, 11, 456, 307, 257, 3603, 13, 639, 307, 20010, 293, 341, 307, 20010, 13, 821, 366, 1045, 9309, 13, 823, 11, 497, 393, 312, 6263, 538, 30], "avg_logprob": -0.20777529584509985, "compression_ratio": 1.3414634146341464, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 788.52, "end": 788.86, "word": " There", "probability": 0.5234375}, {"start": 788.86, "end": 789.12, "word": " are", "probability": 0.8994140625}, {"start": 789.12, "end": 789.26, "word": " a", "probability": 0.94189453125}, {"start": 789.26, "end": 789.42, "word": " lot", "probability": 0.9580078125}, {"start": 789.42, "end": 789.64, "word": " of", "probability": 0.96923828125}, {"start": 789.64, "end": 789.88, "word": " things.", "probability": 0.85791015625}, {"start": 789.98, "end": 790.12, "word": " Thank", "probability": 0.78466796875}, {"start": 790.12, "end": 790.26, "word": " you", "probability": 0.95849609375}, {"start": 790.26, "end": 790.46, "word": " very", "probability": 0.8408203125}, {"start": 790.46, "end": 790.72, "word": " much.", "probability": 0.9130859375}, {"start": 790.86, "end": 790.98, "word": " Now", "probability": 0.8984375}, {"start": 790.98, "end": 791.3, "word": " look,", "probability": 0.67822265625}, {"start": 791.94, "end": 792.38, "word": " there", "probability": 0.81591796875}, {"start": 792.38, "end": 792.96, "word": " is", "probability": 0.94384765625}, {"start": 792.96, "end": 793.18, "word": " a", "probability": 0.99169921875}, {"start": 793.18, "end": 793.72, "word": " fly.", "probability": 0.82763671875}, {"start": 795.06, "end": 795.32, "word": " This", "probability": 0.80517578125}, {"start": 795.32, "end": 795.54, "word": " is", "probability": 0.9541015625}, {"start": 795.54, "end": 795.98, "word": " singular", "probability": 0.98291015625}, {"start": 795.98, "end": 796.32, "word": " and", "probability": 0.75390625}, {"start": 796.32, "end": 796.52, "word": " this", "probability": 0.9462890625}, {"start": 796.52, "end": 796.68, "word": " is", "probability": 0.9580078125}, {"start": 796.68, "end": 797.1, "word": " singular.", "probability": 0.98046875}, {"start": 797.78, "end": 798.38, "word": " There", "probability": 0.65380859375}, {"start": 798.38, "end": 798.74, "word": " are", "probability": 0.947265625}, {"start": 798.74, "end": 799.12, "word": " three", "probability": 0.90966796875}, {"start": 799.12, "end": 799.64, "word": " windows.", "probability": 0.97021484375}, {"start": 801.88, "end": 802.2, "word": " Now,", "probability": 0.62255859375}, {"start": 802.5, "end": 802.88, "word": " R", "probability": 0.467529296875}, {"start": 802.88, "end": 803.42, "word": " can", "probability": 0.955078125}, {"start": 803.42, "end": 803.66, "word": " be", "probability": 0.9541015625}, {"start": 803.66, "end": 803.92, "word": " followed", "probability": 0.8955078125}, {"start": 803.92, "end": 805.18, "word": " by?", "probability": 0.9716796875}], "temperature": 1.0}, {"id": 31, "seek": 83268, "start": 806.68, "end": 832.68, "text": " Singular and singular or plural and plural, as you see. So what determines the noun is the verb. The verb determines the type of noun, whether we need a singular or a plural one. Now, there is two sides to every story. This is informal, but it is used in everyday language, okay?", "tokens": [7474, 1040, 293, 20010, 420, 25377, 293, 25377, 11, 382, 291, 536, 13, 407, 437, 24799, 264, 23307, 307, 264, 9595, 13, 440, 9595, 24799, 264, 2010, 295, 23307, 11, 1968, 321, 643, 257, 20010, 420, 257, 25377, 472, 13, 823, 11, 456, 307, 732, 4881, 281, 633, 1657, 13, 639, 307, 24342, 11, 457, 309, 307, 1143, 294, 7429, 2856, 11, 1392, 30], "avg_logprob": -0.13557692307692307, "compression_ratio": 1.6568047337278107, "no_speech_prob": 0.0, "words": [{"start": 806.68, "end": 807.38, "word": " Singular", "probability": 0.75927734375}, {"start": 807.38, "end": 807.62, "word": " and", "probability": 0.9248046875}, {"start": 807.62, "end": 808.18, "word": " singular", "probability": 0.98388671875}, {"start": 808.18, "end": 808.74, "word": " or", "probability": 0.53759765625}, {"start": 808.74, "end": 809.8, "word": " plural", "probability": 0.75}, {"start": 809.8, "end": 810.3, "word": " and", "probability": 0.9365234375}, {"start": 810.3, "end": 810.7, "word": " plural,", "probability": 0.91650390625}, {"start": 810.96, "end": 811.24, "word": " as", "probability": 0.9619140625}, {"start": 811.24, "end": 811.4, "word": " you", "probability": 0.96630859375}, {"start": 811.4, "end": 811.66, "word": " see.", "probability": 0.9345703125}, {"start": 812.24, "end": 812.24, "word": " So", "probability": 0.79931640625}, {"start": 812.24, "end": 813.62, "word": " what", "probability": 0.49658203125}, {"start": 813.62, "end": 814.64, "word": " determines", "probability": 0.9462890625}, {"start": 814.64, "end": 815.56, "word": " the", "probability": 0.92236328125}, {"start": 815.56, "end": 815.94, "word": " noun", "probability": 0.95751953125}, {"start": 815.94, "end": 816.5, "word": " is", "probability": 0.8876953125}, {"start": 816.5, "end": 816.7, "word": " the", "probability": 0.91259765625}, {"start": 816.7, "end": 816.92, "word": " verb.", "probability": 0.88037109375}, {"start": 817.38, "end": 817.62, "word": " The", "probability": 0.89404296875}, {"start": 817.62, "end": 817.92, "word": " verb", "probability": 0.88916015625}, {"start": 817.92, "end": 818.6, "word": " determines", "probability": 0.94287109375}, {"start": 818.6, "end": 818.82, "word": " the", "probability": 0.919921875}, {"start": 818.82, "end": 819.14, "word": " type", "probability": 0.98193359375}, {"start": 819.14, "end": 819.3, "word": " of", "probability": 0.97119140625}, {"start": 819.3, "end": 819.56, "word": " noun,", "probability": 0.96044921875}, {"start": 819.94, "end": 820.1, "word": " whether", "probability": 0.9189453125}, {"start": 820.1, "end": 820.38, "word": " we", "probability": 0.96435546875}, {"start": 820.38, "end": 820.66, "word": " need", "probability": 0.9296875}, {"start": 820.66, "end": 820.86, "word": " a", "probability": 0.99072265625}, {"start": 820.86, "end": 821.16, "word": " singular", "probability": 0.970703125}, {"start": 821.16, "end": 821.6, "word": " or", "probability": 0.96875}, {"start": 821.6, "end": 821.76, "word": " a", "probability": 0.92822265625}, {"start": 821.76, "end": 822.04, "word": " plural", "probability": 0.9814453125}, {"start": 822.04, "end": 822.84, "word": " one.", "probability": 0.935546875}, {"start": 823.52, "end": 823.82, "word": " Now,", "probability": 0.94921875}, {"start": 824.72, "end": 825.6, "word": " there", "probability": 0.90380859375}, {"start": 825.6, "end": 825.82, "word": " is", "probability": 0.87060546875}, {"start": 825.82, "end": 826.1, "word": " two", "probability": 0.9296875}, {"start": 826.1, "end": 826.58, "word": " sides", "probability": 0.92822265625}, {"start": 826.58, "end": 827.02, "word": " to", "probability": 0.96630859375}, {"start": 827.02, "end": 827.34, "word": " every", "probability": 0.81689453125}, {"start": 827.34, "end": 827.8, "word": " story.", "probability": 0.93310546875}, {"start": 828.24, "end": 828.42, "word": " This", "probability": 0.904296875}, {"start": 828.42, "end": 828.56, "word": " is", "probability": 0.9443359375}, {"start": 828.56, "end": 829.04, "word": " informal,", "probability": 0.8212890625}, {"start": 829.24, "end": 829.42, "word": " but", "probability": 0.92236328125}, {"start": 829.42, "end": 829.56, "word": " it", "probability": 0.94091796875}, {"start": 829.56, "end": 829.72, "word": " is", "probability": 0.92578125}, {"start": 829.72, "end": 830.1, "word": " used", "probability": 0.921875}, {"start": 830.1, "end": 830.92, "word": " in", "probability": 0.94384765625}, {"start": 830.92, "end": 831.3, "word": " everyday", "probability": 0.9052734375}, {"start": 831.3, "end": 831.88, "word": " language,", "probability": 0.86474609375}, {"start": 832.42, "end": 832.68, "word": " okay?", "probability": 0.8955078125}], "temperature": 1.0}, {"id": 32, "seek": 86410, "start": 837.88, "end": 864.1, "text": " We want to do exercise 14. Please look at your book. Exercise 14. Again. Number one. Read it. There isn't any letters or there aren't letters. Plural. Thank you. Yes, please. Go on. Next one. There isn't any mail. Thank you. 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Good. Yes, please. Okay, good. There is a hole. Thank you. Yes, please. Are there cans of beds? Are there. Thank you. Yes, please. Next one. Okay, thank you. Why isn't there a hospital? Good. 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So with one we use has. Thank you. Good. Next one. Very good. Thank you very much. Now look, the United States is big. The United Arab Emirates is a big country.", "tokens": [1485, 13, 407, 365, 472, 321, 764, 575, 13, 1044, 291, 13, 2205, 13, 3087, 472, 13, 4372, 665, 13, 1044, 291, 588, 709, 13, 823, 574, 11, 264, 2824, 3040, 307, 955, 13, 440, 2824, 8625, 38426, 1024, 307, 257, 955, 1941, 13], "avg_logprob": -0.19531250132454767, "compression_ratio": 1.346774193548387, "no_speech_prob": 0.0, "words": [{"start": 951.5, "end": 951.9, "word": " One.", "probability": 0.6416015625}, {"start": 952.24, "end": 952.42, "word": " So", "probability": 0.89111328125}, {"start": 952.42, "end": 952.66, "word": " with", "probability": 0.751953125}, {"start": 952.66, "end": 952.9, "word": " one", "probability": 0.8701171875}, {"start": 952.9, "end": 953.12, "word": " we", "probability": 0.6787109375}, {"start": 953.12, "end": 953.64, "word": " use", "probability": 0.84716796875}, {"start": 953.64, "end": 954.8, "word": " has.", "probability": 0.489990234375}, {"start": 954.92, "end": 955.1, "word": " Thank", "probability": 0.75146484375}, {"start": 955.1, "end": 955.3, "word": " you.", "probability": 0.958984375}, {"start": 955.38, "end": 955.6, "word": " Good.", "probability": 0.794921875}, {"start": 955.9, "end": 956.1, "word": " Next", "probability": 0.87451171875}, {"start": 956.1, "end": 956.48, "word": " one.", "probability": 0.9326171875}, {"start": 960.26, "end": 960.34, "word": " Very", "probability": 0.48291015625}, {"start": 960.34, "end": 960.62, "word": " good.", "probability": 0.92626953125}, {"start": 960.74, "end": 960.9, "word": " Thank", "probability": 0.8994140625}, {"start": 960.9, "end": 961.06, "word": " you", "probability": 0.96435546875}, {"start": 961.06, "end": 961.26, "word": " very", "probability": 0.84619140625}, {"start": 961.26, "end": 961.64, "word": " much.", "probability": 0.91015625}, {"start": 964.58, "end": 965.18, "word": " Now", "probability": 0.908203125}, {"start": 965.18, "end": 965.54, "word": " look,", "probability": 0.794921875}, {"start": 968.24, "end": 968.42, "word": " the", "probability": 0.810546875}, {"start": 968.42, "end": 968.86, "word": " United", "probability": 0.91064453125}, {"start": 968.86, "end": 969.64, "word": " States", "probability": 0.9384765625}, {"start": 969.64, "end": 973.82, "word": " is", "probability": 0.4287109375}, {"start": 973.82, "end": 975.94, "word": " big.", "probability": 0.8212890625}, {"start": 977.18, "end": 977.3, "word": " The", "probability": 0.84912109375}, {"start": 977.3, "end": 977.76, "word": " United", "probability": 0.92919921875}, {"start": 977.76, "end": 978.28, "word": " Arab", "probability": 0.91748046875}, {"start": 978.28, "end": 978.88, "word": " Emirates", "probability": 0.947998046875}, {"start": 978.88, "end": 979.38, "word": " is", "probability": 0.94091796875}, {"start": 979.38, "end": 979.6, "word": " a", "probability": 0.99755859375}, {"start": 979.6, "end": 979.78, "word": " big", "probability": 0.9169921875}, {"start": 979.78, "end": 980.3, "word": " country.", "probability": 0.904296875}], "temperature": 1.0}, {"id": 37, "seek": 100349, "start": 981.35, "end": 1003.49, "text": " The United Arab Emirates is a big country. Look, it ends with S, but it takes what? Singular verb. Now, if you want to use a pronoun instead of the United States, do we use it or they? It. So it what? It is big. It is big. Okay. Now, the Philippians.", "tokens": [440, 2824, 8625, 38426, 1024, 307, 257, 955, 1941, 13, 2053, 11, 309, 5314, 365, 318, 11, 457, 309, 2516, 437, 30, 7474, 1040, 9595, 13, 823, 11, 498, 291, 528, 281, 764, 257, 14144, 2602, 295, 264, 2824, 3040, 11, 360, 321, 764, 309, 420, 436, 30, 467, 13, 407, 309, 437, 30, 467, 307, 955, 13, 467, 307, 955, 13, 1033, 13, 823, 11, 264, 13694, 2567, 13], "avg_logprob": -0.19630281438290234, "compression_ratio": 1.4342857142857144, "no_speech_prob": 0.0, "words": [{"start": 981.35, "end": 981.63, "word": " The", "probability": 0.61572265625}, {"start": 981.63, "end": 982.09, "word": " United", "probability": 0.8251953125}, {"start": 982.09, "end": 982.53, "word": " Arab", "probability": 0.92138671875}, {"start": 982.53, "end": 983.15, "word": " Emirates", "probability": 0.943359375}, {"start": 983.15, "end": 983.67, "word": " is", "probability": 0.916015625}, {"start": 983.67, "end": 983.89, "word": " a", "probability": 0.99560546875}, {"start": 983.89, "end": 984.05, "word": " big", "probability": 0.9140625}, {"start": 984.05, "end": 984.57, "word": " country.", "probability": 0.90771484375}, {"start": 984.91, "end": 985.17, "word": " Look,", "probability": 0.75830078125}, {"start": 985.75, "end": 985.91, "word": " it", "probability": 0.9375}, {"start": 985.91, "end": 986.23, "word": " ends", "probability": 0.919921875}, {"start": 986.23, "end": 986.49, "word": " with", "probability": 0.90625}, {"start": 986.49, "end": 986.81, "word": " S,", "probability": 0.57568359375}, {"start": 986.97, "end": 987.17, "word": " but", "probability": 0.90771484375}, {"start": 987.17, "end": 987.41, "word": " it", "probability": 0.919921875}, {"start": 987.41, "end": 987.75, "word": " takes", "probability": 0.81640625}, {"start": 987.75, "end": 988.11, "word": " what?", "probability": 0.6015625}, {"start": 989.57, "end": 990.13, "word": " Singular", "probability": 0.876953125}, {"start": 990.13, "end": 990.43, "word": " verb.", "probability": 0.7509765625}, {"start": 990.71, "end": 991.21, "word": " Now,", "probability": 0.84765625}, {"start": 991.31, "end": 991.55, "word": " if", "probability": 0.94921875}, {"start": 991.55, "end": 991.73, "word": " you", "probability": 0.96533203125}, {"start": 991.73, "end": 991.99, "word": " want", "probability": 0.884765625}, {"start": 991.99, "end": 992.13, "word": " to", "probability": 0.97216796875}, {"start": 992.13, "end": 992.37, "word": " use", "probability": 0.8857421875}, {"start": 992.37, "end": 992.57, "word": " a", "probability": 0.99169921875}, {"start": 992.57, "end": 993.01, "word": " pronoun", "probability": 0.96728515625}, {"start": 993.01, "end": 993.57, "word": " instead", "probability": 0.78515625}, {"start": 993.57, "end": 993.99, "word": " of", "probability": 0.96923828125}, {"start": 993.99, "end": 994.15, "word": " the", "probability": 0.830078125}, {"start": 994.15, "end": 994.53, "word": " United", "probability": 0.88818359375}, {"start": 994.53, "end": 995.07, "word": " States,", "probability": 0.94091796875}, {"start": 995.19, "end": 995.29, "word": " do", "probability": 0.9404296875}, {"start": 995.29, "end": 995.47, "word": " we", "probability": 0.93017578125}, {"start": 995.47, "end": 995.75, "word": " use", "probability": 0.87451171875}, {"start": 995.75, "end": 995.97, "word": " it", "probability": 0.91064453125}, {"start": 995.97, "end": 996.21, "word": " or", "probability": 0.91943359375}, {"start": 996.21, "end": 996.45, "word": " they?", "probability": 0.9169921875}, {"start": 996.99, "end": 997.37, "word": " It.", "probability": 0.609375}, {"start": 997.57, "end": 998.11, "word": " So", "probability": 0.79931640625}, {"start": 998.11, "end": 998.49, "word": " it", "probability": 0.65283203125}, {"start": 998.49, "end": 998.85, "word": " what?", "probability": 0.52734375}, {"start": 999.11, "end": 999.41, "word": " It", "probability": 0.90673828125}, {"start": 999.41, "end": 999.67, "word": " is", "probability": 0.93896484375}, {"start": 999.67, "end": 999.93, "word": " big.", "probability": 0.904296875}, {"start": 1000.41, "end": 1000.59, "word": " It", "probability": 0.76611328125}, {"start": 1000.59, "end": 1000.83, "word": " is", "probability": 0.94921875}, {"start": 1000.83, "end": 1001.07, "word": " big.", "probability": 0.90625}, {"start": 1001.17, "end": 1001.35, "word": " Okay.", "probability": 0.80419921875}, {"start": 1001.83, "end": 1002.39, "word": " Now,", "probability": 0.95068359375}, {"start": 1002.53, "end": 1002.69, "word": " the", "probability": 0.9228515625}, {"start": 1002.69, "end": 1003.49, "word": " Philippians.", "probability": 0.6407470703125}], "temperature": 1.0}, {"id": 38, "seek": 103335, "start": 1004.5, "end": 1033.36, "text": " Consists. The country consists. It consists. The United Nations has. Has. The organization has. It has. Harrods is a department store. Harrods is like in Gaza, let's say steps. You know steps? Steps. 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Yeah, it is a big mall, a big supermarket in Al Nasri Street, okay? So this is the name of the store. This is the name of the store, okay? This is the name. So we say Stips is or Stips are? Stips is, okay? Stips is a big store. 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This is the name of the store. Harrods is. Now, look. These nouns end with S. But they take what? Singular verb. They refer to a singular noun, not to a plural noun. The news is interesting. 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Eight hours of sleep is enough. This period of time is enough. Okay. Eight hours of sleep. This is a period. It is one period. So this period is what? Enough. Singular. Yeah. Read the other one please. 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This sum, this amount of money is what? Is too much to pay. Thank you. Read the other one please.", "tokens": [467, 307, 886, 709, 13, 639, 2408, 11, 341, 2372, 295, 1460, 307, 437, 30, 1119, 886, 709, 281, 1689, 13, 1044, 291, 13, 17604, 264, 661, 472, 1767, 13], "avg_logprob": -0.20577117320029967, "compression_ratio": 1.2, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 1193.21, "end": 1193.77, "word": " It", "probability": 0.296630859375}, {"start": 1193.77, "end": 1194.33, "word": " is", "probability": 0.76611328125}, {"start": 1194.33, "end": 1194.67, "word": " too", "probability": 0.94677734375}, {"start": 1194.67, "end": 1195.01, "word": " much.", "probability": 0.9365234375}, {"start": 1195.15, "end": 1195.41, "word": " This", "probability": 0.751953125}, {"start": 1195.41, "end": 1195.87, "word": " sum,", "probability": 0.64794921875}, {"start": 1196.45, "end": 1196.83, "word": " this", "probability": 0.93896484375}, {"start": 1196.83, "end": 1197.31, "word": " amount", "probability": 0.90478515625}, {"start": 1197.31, "end": 1197.53, "word": " of", "probability": 0.95751953125}, {"start": 1197.53, "end": 1197.83, "word": " money", "probability": 0.935546875}, {"start": 1197.83, "end": 1198.09, "word": " is", "probability": 0.89013671875}, {"start": 1198.09, "end": 1198.37, "word": " what?", "probability": 0.72314453125}, {"start": 1198.73, "end": 1199.11, "word": " Is", "probability": 0.422119140625}, {"start": 1199.11, "end": 1199.33, "word": " too", "probability": 0.94140625}, {"start": 1199.33, "end": 1199.61, "word": " much", "probability": 0.9208984375}, {"start": 1199.61, "end": 1199.83, "word": " to", "probability": 0.966796875}, {"start": 1199.83, "end": 1200.09, "word": " pay.", "probability": 0.93701171875}, {"start": 1200.41, "end": 1200.67, "word": " Thank", "probability": 0.75244140625}, {"start": 1200.67, "end": 1200.81, "word": " you.", "probability": 0.92626953125}, {"start": 1200.87, "end": 1201.03, "word": " Read", "probability": 0.890625}, {"start": 1201.03, "end": 1201.19, "word": " the", "probability": 0.92138671875}, {"start": 1201.19, "end": 1201.37, "word": " other", "probability": 0.88330078125}, {"start": 1201.37, "end": 1201.65, "word": " one", "probability": 0.9306640625}, {"start": 1201.65, "end": 1202.05, "word": " please.", "probability": 0.587890625}], "temperature": 1.0}, {"id": 46, "seek": 123520, "start": 1205.9, "end": 1235.2, "text": " Miles is five thousand miles. Okay. This is distance. It is one distance. Okay. One distance. So this expresses a distance, expresses amount of money, sum of money and a period of time. So with these, we use what? We use singular verbs. Thank you. Now look at these mathematical expressions. 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Okay. Five times five is what? 25. Now with these arithmetic expressions, what type of verb did we use? Singular. So with arithmetic expressions, we use what? Singular verbs. Thank you. Those people are. 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And fish live. Okay? It takes a plural verb. They take plural verb. Are, cattle are, fish live, and so on. Yeah, read the note, please. 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They require plural verbs. Now look, English is spoken in many countries and the English drink tea. It is the same word, but the meaning is different. 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Very good. So English language is. English language has. English language makes you and so on. But this is the English people from England. Nationality. The English drink. Chinese is his native language. Chinese again, this is what? The language. 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Thank you. That's right. Now, some words can be used or express a language. Some words have more than one meaning. If they express a language, English is. We use a singular verb. But if they express the people, the nationality. 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French for example, French is and French are. Okay, go on. English, Spanish, Chinese, Japanese, Vietnamese, Portuguese, French. Okay, thank you. 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The disabled people who are disabled. The deaf people who are deaf. People who are blind and so on. Okay, any questions? Look at your book please. Page 94. 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The news is. Very good. Thank you. The news is. Thank you. Yeah. Next one. Okay. Thank you very much. The New York Times. This is a newspaper. The New York Times is. Thank you. Yes, please. Next one. 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Complete the sentence. A branch of mathematics. Okay. This is the study. Thank you. 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In number five, statistics. This is the science, okay? But in number six, the statistics in the report. You are right. Thank you. 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Is. Fifty minutes is. Good. Thank you. Next one. Unreasonable price. Nicholas. Thank you. Many people in the world don't have enough to eat. Many people don't have. Very good. Thank you. 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You are right. Thank you. The police are. Thank you. This is a type of disease. Yeah. Thank you. The French are. What do you mean by the French here? Nationality or people or language? Very good. 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Most people are not in danger at their time, but there have been instances of allergic transformations. Okay, thank you very much. Good. You are right. Thank you. Now, make sure that you got the right answers. 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And let's make a quick summary of this lecture. Okay, let's make a quick summary for this lecture. What did we talk about today? Go on. Yes, please. 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If it is plural noun, we use the plural noun. Good. So these expressions of a quantity can be followed by a singular noun and a singular verb or a plural and a plural. Thank you. Yes, please. 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And they are an exception to the rule. Okay. Thank you. Because they take plural nouns and singular verbs. Thank you. Okay. Subjects. Okay. They are singular nouns. They take singular verbs. Yes, please. Very good. 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Good. Two and four is, two is far. Yeah. 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So some words express a language. English is easy. This is the language. But when we say the English, people who are from England. Okay, the English are. The English like. Yeah? 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Thank you very much. Good. Yes, please. Plural nouns. You are right. The poor are, the blind are good. Thank you. The rich are. Thank you. Yeah. Okay. 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Yeah? Yeah, don't end with S. Okay, people is. People are. Sorry. Yeah. Yeah, they don't end with S, but they take plural. 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The United States, for example. Okay, thank you very much. Good. And finally, yeah.", "tokens": [10404, 436, 917, 365, 318, 11, 1392, 13, 440, 2824, 3040, 11, 337, 1365, 13, 1033, 11, 1309, 291, 588, 709, 13, 2205, 13, 400, 2721, 11, 1338, 13], "avg_logprob": -0.3739583412806193, "compression_ratio": 1.0961538461538463, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1987.57, "end": 1988.01, "word": " Though", "probability": 0.03973388671875}, {"start": 1988.01, "end": 1988.45, "word": " they", "probability": 0.83642578125}, {"start": 1988.45, "end": 1988.71, "word": " end", "probability": 0.90283203125}, {"start": 1988.71, "end": 1988.91, "word": " with", "probability": 0.90380859375}, {"start": 1988.91, "end": 1989.21, "word": " S,", "probability": 0.650390625}, {"start": 1989.47, "end": 1989.73, "word": " okay.", "probability": 0.7470703125}, {"start": 1990.09, "end": 1990.23, "word": " The", "probability": 0.8330078125}, {"start": 1990.23, "end": 1990.65, "word": " United", "probability": 0.890625}, {"start": 1990.65, "end": 1991.27, "word": " States,", "probability": 0.92919921875}, {"start": 1991.43, "end": 1991.51, "word": " for", "probability": 0.95263671875}, {"start": 1991.51, "end": 1991.99, "word": " example.", "probability": 0.97412109375}, {"start": 1993.11, "end": 1993.33, "word": " Okay,", "probability": 0.84765625}, {"start": 1993.53, "end": 1993.71, "word": " thank", "probability": 0.84619140625}, {"start": 1993.71, "end": 1993.85, "word": " you", "probability": 0.9658203125}, {"start": 1993.85, "end": 1994.07, "word": " very", "probability": 0.85888671875}, {"start": 1994.07, "end": 1994.31, "word": " much.", "probability": 0.912109375}, {"start": 1994.39, "end": 1994.55, "word": " Good.", "probability": 0.85205078125}, {"start": 1994.71, "end": 1994.77, "word": " And", "probability": 0.9404296875}, {"start": 1994.77, "end": 1995.33, "word": " finally,", "probability": 0.84228515625}, {"start": 1995.55, "end": 1995.77, "word": " yeah.", "probability": 0.87841796875}], "temperature": 1.0}, {"id": 76, "seek": 201364, "start": 2007.54, "end": 2013.64, "text": " Okay, in plural writing, we use our, okay, thank you very much for today.", "tokens": [1033, 11, 294, 25377, 3579, 11, 321, 764, 527, 11, 1392, 11, 1309, 291, 588, 709, 337, 965, 13], "avg_logprob": -0.2945312589406967, "compression_ratio": 1.0136986301369864, "no_speech_prob": 0.0, "words": [{"start": 2007.54, "end": 2008.12, "word": " Okay,", "probability": 0.61474609375}, {"start": 2009.06, "end": 2009.46, "word": " in", "probability": 0.8876953125}, {"start": 2009.46, "end": 2010.14, "word": " plural", "probability": 0.59814453125}, {"start": 2010.14, "end": 2010.74, "word": " writing,", "probability": 0.931640625}, {"start": 2010.96, "end": 2010.96, "word": " we", "probability": 0.92578125}, {"start": 2010.96, "end": 2011.32, "word": " use", "probability": 0.900390625}, {"start": 2011.32, "end": 2011.62, "word": " our,", "probability": 0.595703125}, {"start": 2011.9, "end": 2012.2, "word": " okay,", "probability": 0.88232421875}, {"start": 2012.42, "end": 2012.6, "word": " thank", "probability": 0.85791015625}, {"start": 2012.6, "end": 2012.72, "word": " you", "probability": 0.9658203125}, {"start": 2012.72, "end": 2012.9, "word": " very", "probability": 0.85205078125}, {"start": 2012.9, "end": 2013.14, "word": " much", "probability": 0.91015625}, {"start": 2013.14, "end": 2013.34, "word": " for", "probability": 0.9501953125}, {"start": 2013.34, "end": 2013.64, "word": " today.", "probability": 0.845703125}], "temperature": 1.0}], "language": "en", "language_probability": 1.0, "duration": 2016.583375, "duration_after_vad": 1885.0912499999952} \ No newline at end of file diff --git a/PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/31n8CPEpBQY_postprocess.srt b/PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/31n8CPEpBQY_postprocess.srt new file mode 100644 index 0000000000000000000000000000000000000000..e9bdfc03b1f806dd85765487ee8621da056d973e --- /dev/null +++ b/PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/31n8CPEpBQY_postprocess.srt @@ -0,0 +1,1996 @@ +1 +00:00:20,970 --> 00:00:24,010 +Good morning to you all. Good morning. How are + +2 +00:00:24,010 --> 00:00:27,650 +you? Fine. And you? I'm nice. Thank you very much. + +3 +00:00:27,810 --> 00:00:31,530 +Feeling well today? Fine. Fine. Good. So let's + +4 +00:00:31,530 --> 00:00:35,050 +start with a smile. It is a nice day today. A nice + +5 +00:00:35,050 --> 00:00:42,810 +weather. Okay. You know Marwa has a story. Marwa + +6 +00:00:42,810 --> 00:00:46,770 +usually comes by bus to the university. You know + +7 +00:00:46,770 --> 00:00:49,710 +what happened today? No. + +8 +00:00:59,910 --> 00:01:09,210 +When she arrived at + +9 +00:01:09,210 --> 00:01:19,250 +the station, the bus station, the bus had + +10 +00:01:19,250 --> 00:01:29,030 +left. When she arrived, the bus had left. Did she + +11 +00:01:29,030 --> 00:01:34,630 +come by bus? No. Did she catch the bus? No. No. + +12 +00:01:35,010 --> 00:01:39,210 +What does that mean? What does that mean? Look, + +13 +00:01:39,710 --> 00:01:45,710 +she arrived, okay, and had left. I used two + +14 +00:01:45,710 --> 00:01:49,270 +tenses. The two tenses happened in the past. Good. + +15 +00:01:49,730 --> 00:01:56,650 +Which happened before? Yes, please. Very good. The + +16 +00:01:56,650 --> 00:02:00,070 +bus left, then she arrived. Now, we use two + +17 +00:02:00,070 --> 00:02:05,130 +tenses. Which tense is this? This, the past + +18 +00:02:05,130 --> 00:02:09,110 +simple. Good. And this one? Okay, good. So, can + +19 +00:02:09,110 --> 00:02:13,630 +you tell me why or when do we use the past + +20 +00:02:13,630 --> 00:02:18,200 +perfect? Yes, Yasmin. When we have two actions, + +21 +00:02:18,620 --> 00:02:22,600 +someone happens before another. Very good. Someone + +22 +00:02:22,600 --> 00:02:27,180 +completed, okay, finished, started and completed + +23 +00:02:27,180 --> 00:02:31,460 +before another action or before another time. This + +24 +00:02:31,460 --> 00:02:32,160 +is nice. Good. + +25 +00:02:48,040 --> 00:02:55,360 +Now look, read the example please. Yes, read it. + +26 +00:02:57,880 --> 00:03:02,620 +Thank you. + +27 +00:03:02,960 --> 00:03:09,680 +Look at the time, left at 9.30, arrived at 10, + +28 +00:03:09,760 --> 00:03:12,700 +which happened before? Which happened? One + +29 +00:03:12,700 --> 00:03:16,300 +speaker, please. One speaker. Yes, please. Okay, + +30 +00:03:16,400 --> 00:03:21,280 +thank you. Ali left before Sami arrived. The two + +31 +00:03:21,280 --> 00:03:24,500 +actions happened in the past. But according to the + +32 +00:03:24,500 --> 00:03:29,140 +time given, we know that this happened first. So + +33 +00:03:29,140 --> 00:03:34,760 +if we want to talk about or to use two tenses to + +34 +00:03:34,760 --> 00:03:39,680 +express the situation, we say, yes or no. What do + +35 +00:03:39,680 --> 00:03:46,560 +we say, Ali? Very good. Ali had already left when + +36 +00:03:46,560 --> 00:03:50,620 +Sami arrived. It means what? First, Ali left. + +37 +00:03:50,820 --> 00:03:57,860 +Second, Sami arrived. Thank you. Read please, + +38 +00:03:58,380 --> 00:04:01,980 +Naveen. The bus permit expresses an activity that + +39 +00:04:01,980 --> 00:04:04,740 +was completed for another activity four times. + +40 +00:04:05,260 --> 00:04:08,560 +Thank you very much. Good. Yeah. What do you + +41 +00:04:08,560 --> 00:04:12,520 +understand, Noor? Can you summarize? Yeah. + +42 +00:04:20,440 --> 00:04:23,260 +Very good, thank you very much. Happened, + +43 +00:04:23,340 --> 00:04:27,400 +completed before the other tense. Thank you. Now, + +44 +00:04:28,320 --> 00:04:29,880 +read the other sentence, Basma. + +45 +00:04:33,980 --> 00:04:39,100 +Okay, thank you very much. Sami got Ali had + +46 +00:04:39,100 --> 00:04:44,990 +already left. Did they meet? Did Sami see Ali? Did + +47 +00:04:44,990 --> 00:04:50,410 +Sami see Ali? Thank you. + +48 +00:04:51,110 --> 00:04:56,450 +So, he did not see Ali. Why? How did you know? Had + +49 +00:04:56,450 --> 00:05:01,050 +already left. Thank you very much. Now, already. + +50 +00:05:01,470 --> 00:05:05,470 +When I say Ali had left, does it give you a good + +51 +00:05:05,470 --> 00:05:09,610 +meaning, a good grammar? Yes, when I use already. + +52 +00:05:10,730 --> 00:05:13,930 +Already, to emphasize the meaning, very good. So + +53 +00:05:13,930 --> 00:05:18,870 +we use some adverbs, some reference to the time, + +54 +00:05:19,030 --> 00:05:22,490 +some words that refer to the, some words to + +55 +00:05:22,490 --> 00:05:26,110 +emphasize the action. The action has already, we + +56 +00:05:26,110 --> 00:05:29,990 +say already. When I say also by the time, this is + +57 +00:05:29,990 --> 00:05:33,570 +another time expression used. Okay, another + +58 +00:05:33,570 --> 00:05:38,420 +expression used with the past perfect. Now, read + +59 +00:05:38,420 --> 00:05:44,900 +Sahar the first sentence, please. She wants to + +60 +00:05:44,900 --> 00:05:46,180 +visit Cairo. + +61 +00:05:48,580 --> 00:05:54,720 +Good. She wants to visit. She has seen. What is + +62 +00:05:54,720 --> 00:05:58,420 +the tense here? Present simple. And this one? + +63 +00:05:58,900 --> 00:06:03,060 +Present perfect. Good. Which happened first? The + +64 +00:06:03,060 --> 00:06:06,500 +simple or the perfect? Yes, please. Very good. + +65 +00:06:07,350 --> 00:06:11,570 +Okay, the perfect. So again, because she has seen, + +66 +00:06:12,030 --> 00:06:15,870 +she wants. Okay? Now read the other example, + +67 +00:06:16,190 --> 00:06:21,490 +please, Ayah. Read this one. Good. + +68 +00:06:25,510 --> 00:06:29,350 +She wanted to visit because she had seen. Again, + +69 +00:06:29,770 --> 00:06:34,250 +the simple past and the? Simple past. Okay. Which + +70 +00:06:34,250 --> 00:06:38,990 +happened first? The perfect, very good. Now look, + +71 +00:06:40,250 --> 00:06:44,790 +present simple, present perfect. Past simple, past + +72 +00:06:44,790 --> 00:06:49,870 +perfect. The present simple happens before the + +73 +00:06:49,870 --> 00:06:52,970 +present perfect. The present perfect happens + +74 +00:06:52,970 --> 00:06:56,590 +before the present simple. And the past perfect + +75 +00:06:56,590 --> 00:07:00,330 +happens before the past simple. Okay, so the + +76 +00:07:00,330 --> 00:07:05,440 +perfect. Okay? Happens before the symbol. The + +77 +00:07:05,440 --> 00:07:09,620 +relationship between the present symbol and the + +78 +00:07:09,620 --> 00:07:13,380 +present perfect is similar to that between the + +79 +00:07:13,380 --> 00:07:17,060 +past symbol and the past perfect. In other words, + +80 +00:07:17,540 --> 00:07:21,320 +the perfect happens before what? Before the + +81 +00:07:21,320 --> 00:07:24,820 +symbol. Good. And read Najwa, this one. + +82 +00:07:35,820 --> 00:07:36,280 +Okay, + +83 +00:07:41,220 --> 00:07:45,220 +thank you very much. Again, when we use the symbol + +84 +00:07:45,220 --> 00:07:51,000 +with the perfect, okay, the perfect happens before + +85 +00:07:51,960 --> 00:07:54,360 +Okay, thank you very much. That's nice. Good. + +86 +00:07:56,800 --> 00:08:01,900 +Could you read this example, please? Yeah. She had + +87 +00:08:01,900 --> 00:08:04,740 +met as a manager of many companies. Okay, Jones. + +88 +00:08:06,220 --> 00:08:08,640 +On many occasions. This is enough. Thank you. + +89 +00:08:08,820 --> 00:08:12,840 +Good. She had met the manager on many occasions. + +90 +00:08:13,260 --> 00:08:17,160 +She was a reporter for example. She wanted to make + +91 +00:08:17,160 --> 00:08:21,440 +a research and she visited the manager and visited + +92 +00:08:21,440 --> 00:08:24,720 +the manager and repeated the action and repeated + +93 +00:08:24,720 --> 00:08:29,740 +the action. The manager offered her a job. Okay? + +94 +00:08:29,940 --> 00:08:35,300 +The manager offered her a job. Now, She had met + +95 +00:08:35,300 --> 00:08:42,140 +the manager on many occasions before she got the + +96 +00:08:42,140 --> 00:08:46,720 +job. I have two actions, okay? The first action + +97 +00:08:46,720 --> 00:08:51,560 +was, okay, it is past perfect, but you know, it + +98 +00:08:51,560 --> 00:08:55,180 +was repeated. That's right. Thank you. It was + +99 +00:08:55,180 --> 00:08:59,120 +repeated. Happened again and again and again. Then + +100 +00:08:59,120 --> 00:09:02,560 +another action happened. Okay? Complete, please + +101 +00:09:02,560 --> 00:09:06,300 +read. Use the bus bell to talk about repeated + +102 +00:09:06,300 --> 00:09:09,940 +actions in the bus that took place before another + +103 +00:09:09,940 --> 00:09:13,040 +event in the bus. Thank you very much. I had + +104 +00:09:13,040 --> 00:09:18,680 +visited the area before I bought the house. I had + +105 +00:09:18,680 --> 00:09:22,280 +visited the area before I bought the house. I + +106 +00:09:22,280 --> 00:09:27,740 +wanted to live in a new area, so I visited it a + +107 +00:09:27,740 --> 00:09:32,300 +lot of times, okay? Then I bought. Can you give me + +108 +00:09:32,300 --> 00:09:37,730 +examples about yourself? Examples about yourself. + +109 +00:09:42,110 --> 00:09:49,790 +Now, Suha has a new bag. You know what did she do? + +110 +00:09:50,430 --> 00:09:55,090 +She had visited many shops before she bought the + +111 +00:09:55,090 --> 00:10:00,950 +bag. Okay. She had visited. So again, the action + +112 +00:10:00,950 --> 00:10:05,010 +was repeated before another action happened or + +113 +00:10:05,010 --> 00:10:14,170 +started. Yes. Very good. + +114 +00:10:14,670 --> 00:10:20,290 +I had gone. Okay, she came and came and came then + +115 +00:10:20,290 --> 00:10:22,970 +she started. Thank you. Yes, please. Yes mean + +116 +00:10:22,970 --> 00:10:26,030 +Thank + +117 +00:10:26,030 --> 00:10:29,670 +you very much good now read the other example, + +118 +00:10:29,870 --> 00:10:35,150 +please read Thank + +119 +00:10:35,150 --> 00:10:40,830 +you very much look had left and left Had left and + +120 +00:10:40,830 --> 00:10:47,390 +left Okay now This is what? Past perfect. And this + +121 +00:10:47,390 --> 00:10:53,550 +is what? Past simple. Look, when we talk about the + +122 +00:10:53,550 --> 00:10:57,070 +time relation between some verbs. If I say, for + +123 +00:10:57,070 --> 00:11:05,260 +example, eat and watch TV. Which usually happens + +124 +00:11:05,260 --> 00:11:08,960 +first? You want to eat and you want to watch TV? + +125 +00:11:13,360 --> 00:11:19,860 +No, I'm asking you. Which happens first? In other + +126 +00:11:19,860 --> 00:11:23,720 +words, is there a clear time relationship between + +127 +00:11:23,720 --> 00:11:29,370 +the two verbs? No. Sometimes I want to eat. I eat + +128 +00:11:29,370 --> 00:11:32,930 +because it's not time for my favorite program. I + +129 +00:11:32,930 --> 00:11:36,010 +have some minutes to eat, right? And sometimes, + +130 +00:11:37,220 --> 00:11:42,680 +Yeah, the program has already started. So I watch + +131 +00:11:42,680 --> 00:11:47,740 +the program, I watch TV, then I eat, right? If I + +132 +00:11:47,740 --> 00:11:51,840 +want to make the time relationship between the two + +133 +00:11:51,840 --> 00:11:55,020 +actions clear, in other words, if I want to tell + +134 +00:11:55,020 --> 00:11:58,540 +the reader which action happened first, I use + +135 +00:11:58,540 --> 00:12:03,080 +what? Before and after. Before and after, very + +136 +00:12:03,080 --> 00:12:08,870 +good. I can use before or after, or? Okay. Before. + +137 +00:12:10,810 --> 00:12:19,010 +After. Or we use what? The past perfect. Okay? We + +138 +00:12:19,010 --> 00:12:22,590 +use the past perfect. So, we use the past perfect + +139 +00:12:22,590 --> 00:12:25,270 +to show the time relationship between the two + +140 +00:12:25,270 --> 00:12:30,270 +actions. Or we use what? Before or after. Now, + +141 +00:12:30,590 --> 00:12:34,970 +when I say before I + +142 +00:12:40,330 --> 00:12:48,590 +I watched TV. Now according to the sentence, in + +143 +00:12:48,590 --> 00:12:52,770 +this sentence, is the time relationship between + +144 +00:12:52,770 --> 00:12:56,950 +the two verbs clear? Yes. Which happened first? + +145 +00:12:58,370 --> 00:13:02,810 +Which happened first? Watched. So it means before + +146 +00:13:02,810 --> 00:13:06,250 +I ate, I watched it. This happened, this, this + +147 +00:13:06,250 --> 00:13:12,330 +happened. Okay. Now can I say after? After I ate. + +148 +00:13:12,750 --> 00:13:17,550 +Who's the speaker? After? After I ate. After I + +149 +00:13:17,550 --> 00:13:20,690 +want the same, the same meaning. I don't want to + +150 +00:13:20,690 --> 00:13:23,630 +change the meaning. You can say after I ate, I + +151 +00:13:23,630 --> 00:13:26,210 +watched it. But I want the same meaning. After? + +152 +00:13:27,190 --> 00:13:35,380 +Yes, go on. After I watched TV, + +153 +00:13:36,540 --> 00:13:38,300 +I ate. + +154 +00:13:40,320 --> 00:13:43,900 +After I watched, I ate. Is the time relationship + +155 +00:13:43,900 --> 00:13:47,040 +between the two verbs, the simple past and the + +156 +00:13:47,040 --> 00:13:51,320 +simple past clear? Yes. Is it clear? Can you say + +157 +00:13:51,320 --> 00:13:55,620 +which one happened first? Yes. So is it necessary + +158 +00:13:55,620 --> 00:14:00,680 +to use the past perfect in this sentence? No, it + +159 +00:14:00,680 --> 00:14:04,320 +is not necessary. We use the past perfect to show + +160 +00:14:04,320 --> 00:14:07,800 +which action happened first. But if the time + +161 +00:14:07,800 --> 00:14:11,500 +relationship between the two actions is clear, use + +162 +00:14:11,500 --> 00:14:14,760 +the symbol and the symbol. We don't need it. So it + +163 +00:14:14,760 --> 00:14:17,740 +is not necessary to use what? The past perfect. + +164 +00:14:19,190 --> 00:14:22,870 +But it is not commonly not recommended. Okay. We + +165 +00:14:22,870 --> 00:14:26,890 +said it is unnecessary. Unnecessary. Right? + +166 +00:14:39,450 --> 00:14:43,310 +Yes. Read the sentence again, Lama. Sami had left + +167 +00:14:43,310 --> 00:14:46,890 +before Ali got there. Sami left before Ali got + +168 +00:14:46,890 --> 00:14:52,300 +there. Okay. The two sentences have the same + +169 +00:14:52,300 --> 00:14:56,400 +meaning. So again, if the time relationship is + +170 +00:14:56,400 --> 00:15:01,240 +clear, don't use what? The perfect. Yeah. Read the + +171 +00:15:01,240 --> 00:15:02,420 +other sentence, please. + +172 +00:15:06,420 --> 00:15:11,760 +Okay. Thank you. Now, is the time relationship + +173 +00:15:11,760 --> 00:15:15,420 +clear between the two verbs? When do you usually + +174 +00:15:15,420 --> 00:15:17,540 +go to bed? While you are having the guests, you + +175 +00:15:17,540 --> 00:15:20,440 +say, good night, my guests, I'm going to bed and + +176 +00:15:20,440 --> 00:15:26,280 +you leave them? No. Okay. So one stops, one is + +177 +00:15:26,280 --> 00:15:30,180 +completed, the other what? Starts. Okay. Yeah. So + +178 +00:15:30,180 --> 00:15:35,100 +again, go on. The two sentences. So it is not + +179 +00:15:35,100 --> 00:15:39,010 +necessary to say after the guests had left.Okay? + +180 +00:15:39,590 --> 00:15:44,330 +The past perfect is not needed. It is not needed. + +181 +00:15:44,430 --> 00:15:48,750 +Unnecessary in this sentence. Again, because the + +182 +00:15:48,750 --> 00:15:52,770 +time relationship between the two actions is what? + +183 +00:15:52,970 --> 00:15:59,220 +Clear. Okay. Yes. Just when we use after or + +184 +00:15:59,220 --> 00:16:02,660 +before, the time relationship is clear. Okay, so + +185 +00:16:02,660 --> 00:16:05,780 +if the time relation and what do you mean by + +186 +00:16:05,780 --> 00:16:08,120 +clear? You know which happened first and which + +187 +00:16:08,120 --> 00:16:11,320 +happened next, right? And we use the past perfect + +188 +00:16:11,320 --> 00:16:14,040 +also to show which happened first and which + +189 +00:16:14,040 --> 00:16:18,440 +happened next, right? So it is not necessary to + +190 +00:16:18,440 --> 00:16:21,660 +use the past perfect with after and before. Not + +191 +00:16:21,660 --> 00:16:28,590 +always. At all. What do you mean by at all? All + +192 +00:16:28,590 --> 00:16:32,290 +the time, we must use the past simple because the + +193 +00:16:32,290 --> 00:16:34,270 +time relationship is important. Okay, if the past + +194 +00:16:34,270 --> 00:16:38,090 +simple conveys your message, gives you a complete + +195 +00:16:38,090 --> 00:16:40,870 +meaning, don't use the perfect. Right? You don't + +196 +00:16:40,870 --> 00:16:44,910 +need. Try to use the simple. Now, we use the + +197 +00:16:44,910 --> 00:16:49,510 +tenses to convey a certain message. We said, why + +198 +00:16:49,510 --> 00:16:54,750 +do we learn grammar? To write well and to speak + +199 +00:16:54,750 --> 00:16:59,210 +well, right? So if I can convey my message to the + +200 +00:16:59,210 --> 00:17:02,610 +reader or to the listener with the symbol, use the + +201 +00:17:02,610 --> 00:17:05,190 +symbol. If I need the progressive, I use the + +202 +00:17:05,190 --> 00:17:09,130 +progressive. If I need the perfect, I use the + +203 +00:17:09,130 --> 00:17:14,310 +perfect, and so on. So if you convey your message + +204 +00:17:14,310 --> 00:17:18,390 +by the symbol only, don't use the perfect. Okay? + +205 +00:17:23,650 --> 00:17:28,690 +Read please. If either before or after is used in + +206 +00:17:28,690 --> 00:17:31,830 +the sentence, the past perfect is often not + +207 +00:17:31,830 --> 00:17:35,310 +necessary. Yeah, not necessary. Because the time + +208 +00:17:35,310 --> 00:17:38,830 +relationship is already clear. The simple past may + +209 +00:17:38,830 --> 00:17:42,730 +be used for both. Thank you. We use the simple + +210 +00:17:42,730 --> 00:17:46,170 +past and the simple past. Now talk about + +211 +00:17:46,170 --> 00:17:49,690 +yourselves. Tell me. Tell me. Yeah. Use the simple + +212 +00:17:49,690 --> 00:17:51,630 +and the simple with after and before. + +213 +00:17:54,730 --> 00:17:55,430 +Yes, please. + +214 +00:17:59,450 --> 00:18:04,950 +I ate my breakfast. Before I left, I ate my + +215 +00:18:04,950 --> 00:18:09,090 +breakfast. Thank you. Good. Yes, Marwa. After I + +216 +00:18:09,090 --> 00:18:12,950 +reached the university, I rushed to the class. + +217 +00:18:13,070 --> 00:18:15,830 +After I reached, I rushed to the class. Very good. + +218 +00:18:15,930 --> 00:18:19,030 +Thank you. Go on. Go on. Other examples. Yes, tell + +219 +00:18:19,030 --> 00:18:22,810 +me about yourself. After I reached, I rushed. + +220 +00:18:22,910 --> 00:18:23,030 +Yeah. + +221 +00:18:26,580 --> 00:18:29,500 +Okay, before I slept, I returned my homework. + +222 +00:18:29,640 --> 00:18:32,400 +Good, thank you very much. Before I went to my + +223 +00:18:32,400 --> 00:18:38,360 +university, I kissed my mother. + +224 +00:18:38,540 --> 00:18:42,480 +Good, thank you. Before I went to my bed, I + +225 +00:18:42,480 --> 00:18:45,100 +brushed my teeth. Before I went, I brushed my + +226 +00:18:45,100 --> 00:18:47,600 +teeth. Thank you very much. So again, the time + +227 +00:18:47,600 --> 00:18:51,440 +relationship is clear between the two actions. So + +228 +00:18:51,440 --> 00:18:56,120 +the symbol and the symbol Is okay. Is enough. + +229 +00:18:56,900 --> 00:19:02,640 +Yeah. Read please the other, the example. + +230 +00:19:05,280 --> 00:19:11,960 +Thank you. Now, Ali didn't go to the movies with + +231 +00:19:11,960 --> 00:19:18,260 +us. He had seen it. He had seen it. Okay. Is it a + +232 +00:19:18,260 --> 00:19:21,300 +good grammar? Does it give you a good meaning? + +233 +00:19:21,580 --> 00:19:25,960 +Yes. Okay. Now, when I say he had already seen. He + +234 +00:19:25,960 --> 00:19:30,780 +had already seen. Already what? Emphasizes. Very + +235 +00:19:30,780 --> 00:19:34,500 +good. Emphasizes the meaning. Okay? It emphasizes + +236 +00:19:34,500 --> 00:19:36,980 +the meaning. Go on, please. Read the other one. + +237 +00:19:37,760 --> 00:19:41,580 +Yeah? I saw the film last night. I had never seen + +238 +00:19:41,580 --> 00:19:44,740 +it before. I had never seen. Never again + +239 +00:19:44,740 --> 00:19:47,580 +emphasizes what? Meaning. The meaning. Thank you. + +240 +00:19:47,660 --> 00:19:47,800 +Yeah? + +241 +00:19:52,170 --> 00:19:52,930 +Okay, + +242 +00:19:57,310 --> 00:20:01,130 +thank you. Now we know which happened first. + +243 +00:20:01,910 --> 00:20:05,070 +Again, to emphasize the idea, to emphasize the + +244 +00:20:05,070 --> 00:20:09,210 +meaning of the past perfect, use these words to + +245 +00:20:09,210 --> 00:20:10,810 +emphasize the meaning. + +246 +00:20:13,610 --> 00:20:18,110 +Where are your keys? Where are your keys? You lost + +247 +00:20:18,110 --> 00:20:26,260 +them? she lost her keys okay she lost her keys yes + +248 +00:20:26,260 --> 00:20:31,260 +where are your keys listen to her i lost my keys + +249 +00:20:31,260 --> 00:20:36,500 +okay she says i lost my keys what did she say she + +250 +00:20:36,500 --> 00:20:40,080 +said that she had lost very good she said that she + +251 +00:20:40,080 --> 00:20:45,270 +had lost repeat your words again please Yeah. I + +252 +00:20:45,270 --> 00:20:48,930 +lost my keys, she says. Again, what did she say? + +253 +00:20:49,070 --> 00:20:51,930 +She said that she had lost her keys. So in the + +254 +00:20:51,930 --> 00:20:54,230 +reported speech, we use what? The past perfect. + +255 +00:20:54,390 --> 00:20:57,890 +The past perfect. Okay. Read the examples, please. + +256 +00:20:58,430 --> 00:21:03,610 +I lost my keys. Go on. Repeated word, Mona said + +257 +00:21:03,610 --> 00:21:10,570 +that she had lost her keys. Good. Thank you. Yeah. + +258 +00:21:12,890 --> 00:21:13,870 +Go on, read. + +259 +00:21:27,140 --> 00:21:27,700 +Okay, + +260 +00:21:30,540 --> 00:21:31,400 +thank you. Good. + +261 +00:21:37,110 --> 00:21:40,230 +This is a piece of writing, a piece of fiction. + +262 +00:21:40,790 --> 00:21:46,390 +You like stories and drama and novels, okay? This + +263 +00:21:46,390 --> 00:21:49,690 +is a piece of writing. Who wants to read? Yes, + +264 +00:21:49,810 --> 00:21:53,890 +please, read. Bill was great that evening. Earlier + +265 +00:21:53,890 --> 00:21:58,830 +in the day, Anne had caught one fish and he had + +266 +00:21:58,830 --> 00:22:02,890 +caught three. They had had a delicious picnic near + +267 +00:22:02,890 --> 00:22:06,800 +the lake and Ben had gone swimming again. It had + +268 +00:22:06,800 --> 00:22:09,800 +been a nearly perfect vacation day. Thank you very + +269 +00:22:09,800 --> 00:22:15,700 +much. Now listen. The writer used what? The past + +270 +00:22:15,700 --> 00:22:18,480 +perfect. And the past perfect. And the past + +271 +00:22:18,480 --> 00:22:22,400 +perfect. Bill felt great. Okay, the past symbol + +272 +00:22:22,400 --> 00:22:26,950 +felt great. Why? The writer wants to tell you why + +273 +00:22:26,950 --> 00:22:34,110 +did he feel sad. Some actions happened before and + +274 +00:22:34,110 --> 00:22:38,440 +as a result of the actions, how did he feel? Okay, + +275 +00:22:38,540 --> 00:22:40,880 +what did he use to convey that message to the + +276 +00:22:40,880 --> 00:22:45,220 +reader? He used what? The past perfect. He used + +277 +00:22:45,220 --> 00:22:49,360 +the past perfect. So the past perfect is used in + +278 +00:22:49,360 --> 00:22:52,660 +formal writing. This is a piece of formal writing. + +279 +00:22:53,020 --> 00:22:56,720 +Okay, a lot of writers use it to emphasize the + +280 +00:22:56,720 --> 00:23:02,640 +idea. Okay, read please. The past perfect is often + +281 +00:23:02,640 --> 00:23:08,980 +found Formal writing, such as what? Good, go on. + +282 +00:23:09,720 --> 00:23:14,180 +In the above sentence, the fiction writer uses the + +283 +00:23:14,180 --> 00:23:17,740 +simple past to say that an event happened in the + +284 +00:23:17,740 --> 00:23:24,120 +fifth degree, and the actor uses the past basic to + +285 +00:23:24,120 --> 00:23:27,900 +explain what had happened before that event. thank + +286 +00:23:27,900 --> 00:23:32,720 +you good so he felt great why because he had + +287 +00:23:32,720 --> 00:23:37,220 +caught he had seen he had had okay explaining what + +288 +00:23:37,220 --> 00:23:40,760 +happened before so feeling happy is a result of + +289 +00:23:40,760 --> 00:23:44,980 +some actions what happened before then he felt + +290 +00:23:44,980 --> 00:23:54,820 +great okay would you read please yeah he finished + +291 +00:23:55,470 --> 00:24:00,350 +What's that? What would you say about that? This + +292 +00:24:00,350 --> 00:24:04,510 +is the short form, the contraction. Okay? + +293 +00:24:05,050 --> 00:24:08,570 +Contracted form. So you can make contractions with + +294 +00:24:08,570 --> 00:24:14,790 +head in the past perfect. Okay. Again, please go + +295 +00:24:14,790 --> 00:24:21,600 +on, read. Contracted with personal pronouns in + +296 +00:24:21,600 --> 00:24:27,520 +informal writing, not I'd finished, I'd, I had. + +297 +00:24:28,040 --> 00:24:32,560 +Look, I'd finished means what? I had, but I'd + +298 +00:24:32,560 --> 00:24:39,520 +like, I, I would. Okay, now would and had are + +299 +00:24:39,520 --> 00:24:43,880 +contracted in the same way. Okay, I'd like, it + +300 +00:24:43,880 --> 00:24:48,000 +means what? I would like, but I'd finished? I + +301 +00:24:48,000 --> 00:24:55,780 +have. Good. We want to make a quick summary for + +302 +00:24:55,780 --> 00:24:59,140 +the past perfect. What did we talk about? Yes, + +303 +00:24:59,220 --> 00:25:01,420 +tell me. What did you know about the past perfect + +304 +00:25:01,420 --> 00:25:06,980 +now? Dua. The past perfect is an activity + +305 +00:25:06,980 --> 00:25:12,640 +completed before another activity. Good, thank you + +306 +00:25:12,640 --> 00:25:14,900 +very much. Tell me another point about the past + +307 +00:25:14,900 --> 00:25:15,920 +perfect. Yes, please. + +308 +00:25:23,440 --> 00:25:26,240 +Okay, when the relationship between the two + +309 +00:25:26,240 --> 00:25:30,620 +actions is clear, we use what? The simple past and + +310 +00:25:30,620 --> 00:25:33,140 +the simple past, not the perfect. Thank you very + +311 +00:25:33,140 --> 00:25:33,640 +much. Good. + +312 +00:25:39,170 --> 00:25:41,430 +Thank you very much. Good. Yes Basma. + +313 +00:25:44,650 --> 00:25:46,250 +Good. Thank you. + +314 +00:25:50,590 --> 00:25:55,650 +Thank you very much. To emphasize the action. + +315 +00:25:55,810 --> 00:25:55,910 +Yeah. + +316 +00:26:00,630 --> 00:26:04,770 +Very good. Thank you very much. Now listen. When + +317 +00:26:04,770 --> 00:26:11,660 +we say had visited, had bought, had eaten, had + +318 +00:26:11,660 --> 00:26:16,940 +written. Do you think there was a continuity or a + +319 +00:26:16,940 --> 00:26:20,740 +duration for the action in the past? Do you think + +320 +00:26:20,740 --> 00:26:26,580 +there was a duration? When I say, the boss had + +321 +00:26:26,580 --> 00:26:32,340 +left when I arrived. Had left. Yeah. No duration. + +322 +00:26:33,340 --> 00:26:37,380 +Sometimes I am interested in the continuity of the + +323 +00:26:37,380 --> 00:26:41,960 +action, in the duration of the action. Now, if you + +324 +00:26:41,960 --> 00:26:45,520 +want to tell me about yourself before you came to + +325 +00:26:45,520 --> 00:26:50,150 +the university, Every day, you used to get up + +326 +00:26:50,150 --> 00:26:53,670 +early, take your bag, go to school, sit in the + +327 +00:26:53,670 --> 00:26:58,490 +class, listen to the teacher, write some notes, + +328 +00:26:58,850 --> 00:27:02,150 +then carry your bag again. How long did that + +329 +00:27:02,150 --> 00:27:09,370 +continue? Twelve years. Twelve years. Now, if you + +330 +00:27:09,370 --> 00:27:12,170 +want to talk about yourself, you say, + +331 +00:27:17,430 --> 00:27:27,690 +had been going to school for + +332 +00:27:27,690 --> 00:27:34,650 +what? Twelve years. Okay. Now, it's going to + +333 +00:27:34,650 --> 00:27:39,610 +school. Like eating a sandwich, for example, I had + +334 +00:27:39,610 --> 00:27:43,990 +eaten. Are they the same? No. Now the duration of + +335 +00:27:43,990 --> 00:27:48,210 +the action is important here. 12 years. It means I + +336 +00:27:48,210 --> 00:27:52,850 +had been going to school for 12 years before I + +337 +00:27:52,850 --> 00:27:56,390 +joined the university. Before I joined. So you + +338 +00:27:56,390 --> 00:27:59,470 +joined the university and you had been going to + +339 +00:27:59,470 --> 00:28:05,810 +school. The first action started, continued in the + +340 +00:28:05,810 --> 00:28:09,850 +past, okay? There was continuity, duration for the + +341 +00:28:09,850 --> 00:28:13,710 +action. Then another action started, which is + +342 +00:28:13,710 --> 00:28:19,890 +what? Joining the school. Joining the university. + +343 +00:28:36,120 --> 00:28:39,760 +Read the example, please. Yes, go ahead. Ali + +344 +00:28:39,760 --> 00:28:42,660 +finally came at six o'clock. I had been waiting + +345 +00:28:42,660 --> 00:28:45,580 +for him since four minutes. Thank you very much. + +346 +00:28:45,640 --> 00:28:52,900 +Good. Look, Ali finally came. I was waiting, Ali. + +347 +00:28:54,200 --> 00:28:56,900 +I became very tired of waiting. Do you like + +348 +00:28:56,900 --> 00:29:01,580 +waiting? No. Nobody likes waiting. Okay, finally + +349 +00:29:01,580 --> 00:29:07,790 +came. I had been waiting. I had been waiting. What + +350 +00:29:07,790 --> 00:29:15,670 +do you understand? I had been waiting. Yeah. Was + +351 +00:29:15,670 --> 00:29:21,670 +continuous, was in progress in the past. So, I had + +352 +00:29:21,670 --> 00:29:26,450 +been waiting Ali. It was very difficult for me. I + +353 +00:29:26,450 --> 00:29:30,810 +had been waiting for Ali since so and so. So + +354 +00:29:30,810 --> 00:29:34,190 +again, I want to show the duration, that the + +355 +00:29:34,190 --> 00:29:38,090 +action was in progress. So I say, I had been + +356 +00:29:38,090 --> 00:29:42,520 +waiting. Now Ali finally came. Ali came, but + +357 +00:29:42,520 --> 00:29:46,640 +before he came, I had been waiting. And the + +358 +00:29:46,640 --> 00:29:49,620 +duration of the action, the continuity of the + +359 +00:29:49,620 --> 00:29:52,480 +progress of the action in the past was important. + +360 +00:29:52,660 --> 00:29:55,720 +Thank you. Read please the other one. Yes, read. + +361 +00:30:01,720 --> 00:30:02,840 +Yeah, four. + +362 +00:30:06,400 --> 00:30:13,260 +Thank you. Had been looking. Day and night. Okay? + +363 +00:30:13,980 --> 00:30:18,840 +In every place. Had been looking. Before what? + +364 +00:30:19,460 --> 00:30:23,680 +Okay, they caught him. Yeah, they caught him. So + +365 +00:30:23,680 --> 00:30:28,020 +again, there was a duration for the action in the + +366 +00:30:28,020 --> 00:30:32,260 +past. There was continuity. The action was in a + +367 +00:30:32,260 --> 00:30:35,580 +progress before another action started. The first + +368 +00:30:35,580 --> 00:30:40,620 +action which was in a progress is what had been + +369 +00:30:40,620 --> 00:30:45,650 +looking. Okay, then what happened then? They + +370 +00:30:45,650 --> 00:30:51,230 +caught him. Good. Thank you. Yes, please read. The + +371 +00:30:51,230 --> 00:31:05,530 +duration of + +372 +00:31:05,530 --> 00:31:08,890 +an activity emphasizes the duration of an + +373 +00:31:08,890 --> 00:31:12,370 +activity. We are talking again about the bus. + +374 +00:31:26,260 --> 00:31:26,820 +Okay, + +375 +00:31:32,100 --> 00:31:36,740 +good. The other tenses are used more than the past + +376 +00:31:36,740 --> 00:31:39,680 +perfect progressive. It is not very common, but it + +377 +00:31:39,680 --> 00:31:42,640 +is a good tense and it is used, but not very + +378 +00:31:42,640 --> 00:31:48,280 +common tense. Yes, please read the example. + +379 +00:31:58,780 --> 00:31:59,600 +The runners. + +380 +00:32:05,060 --> 00:32:05,500 +Okay, + +381 +00:32:08,520 --> 00:32:13,300 +good. Thank you. Now, look at this sentence. The + +382 +00:32:13,300 --> 00:32:17,680 +runners had been running. okay the runners had + +383 +00:32:17,680 --> 00:32:22,510 +been running does the sentence does the tense. + +384 +00:32:23,090 --> 00:32:26,830 +Tell me anything about the result. What happened + +385 +00:32:26,830 --> 00:32:30,210 +then? Can I understand what happened with the + +386 +00:32:30,210 --> 00:32:34,610 +runners? Did they stop? Did they go on? Did they + +387 +00:32:34,610 --> 00:32:39,450 +continue? No. So the progressive here emphasizes + +388 +00:32:39,450 --> 00:32:43,750 +what? The process, not the result. Not interested, + +389 +00:32:43,910 --> 00:32:47,530 +we cannot. So how can we know something about the + +390 +00:32:47,530 --> 00:32:51,580 +result? how can we know something about the result + +391 +00:32:51,580 --> 00:32:57,940 +look please read the other sentence good + +392 +00:32:57,940 --> 00:33:03,600 +now + +393 +00:33:03,600 --> 00:33:08,060 +the finished line the finished line tells you what + +394 +00:33:09,650 --> 00:33:13,950 +Stopped. Okay? So it tells me something about the + +395 +00:33:13,950 --> 00:33:18,590 +end result. That's right. Now, did the tense tell + +396 +00:33:18,590 --> 00:33:23,190 +me something about the end result? The tense. Is + +397 +00:33:23,190 --> 00:33:26,610 +it the tense? Did I understand this from the tense + +398 +00:33:26,610 --> 00:33:32,940 +or from the context? From the context, okay? The + +399 +00:33:32,940 --> 00:33:35,820 +context. Now, in the first sentence, you know, I + +400 +00:33:35,820 --> 00:33:38,900 +cannot understand. I cannot know anything about + +401 +00:33:38,900 --> 00:33:42,660 +the result. The progressive emphasizes the action. + +402 +00:33:43,740 --> 00:33:46,720 +But here, I can know something about the end + +403 +00:33:46,720 --> 00:33:49,820 +result because something is mentioned. He crossed + +404 +00:33:49,820 --> 00:33:54,980 +the finish line. Okay? Go on, please read. Notice. + +405 +00:34:03,180 --> 00:34:14,740 +Thank you, good. Now, when I say, it was raining + +406 +00:34:14,740 --> 00:34:21,600 +when I left my house. it was raining when i left + +407 +00:34:21,600 --> 00:34:26,560 +my house and it had been raining when i left my + +408 +00:34:26,560 --> 00:34:30,280 +house okay what's the difference between the two + +409 +00:34:30,280 --> 00:34:36,920 +sentences think of that again it was raining when + +410 +00:34:36,920 --> 00:34:41,780 +i left my house it had been raining when i left my + +411 +00:34:41,780 --> 00:34:47,390 +house in the first sentence did i get wet Yes. Did + +412 +00:34:47,390 --> 00:34:52,390 +I walk under the rain? Yes. Yes. Okay. So the, the + +413 +00:34:52,390 --> 00:34:58,430 +rain was okay. It had been raining. Okay. The + +414 +00:34:58,430 --> 00:35:03,210 +streets were wet, right? But did I go under the + +415 +00:35:03,210 --> 00:35:06,550 +rain? No. Thank you. Read please the first + +416 +00:35:06,550 --> 00:35:09,810 +sentence. When the rain started, it was raining + +417 +00:35:09,810 --> 00:35:13,410 +and the streets were wet. It was still raining. + +418 +00:35:14,770 --> 00:35:19,730 +Good. Look past progressive. It was still raining + +419 +00:35:19,730 --> 00:35:23,950 +during the race. Go on. When the race started, it + +420 +00:35:23,950 --> 00:35:27,390 +had been raining and the streets were wet. It + +421 +00:35:27,390 --> 00:35:31,110 +wasn't raining during the race. It had already + +422 +00:35:31,110 --> 00:35:36,270 +stopped. Very good. Again, what is the difference + +423 +00:35:36,270 --> 00:35:40,090 +between the two sentences? Who can repeat? Who can + +424 +00:35:40,090 --> 00:35:40,470 +repeat? + +425 +00:35:43,330 --> 00:35:48,590 +Yes please, Marwa. When we used the past + +426 +00:35:48,590 --> 00:35:52,530 +progressive, it showed that the action finished + +427 +00:35:52,530 --> 00:35:55,630 +before, sorry it showed that the action was + +428 +00:35:55,630 --> 00:36:01,250 +continuing when I left, when I was Okay, good. + +429 +00:36:01,930 --> 00:36:04,950 +Gone. Okay. But in the second example that you + +430 +00:36:04,950 --> 00:36:11,470 +said, the rain was stopped, already stopped when I + +431 +00:36:11,470 --> 00:36:14,590 +left home. So I didn't, I didn't pay attention. + +432 +00:36:14,670 --> 00:36:17,010 +Thank you very much. You remember when you went + +433 +00:36:17,010 --> 00:36:20,090 +home yesterday. Remember what happened with you. + +434 +00:36:20,650 --> 00:36:23,530 +Okay? When you went home, your father was + +435 +00:36:23,530 --> 00:36:27,870 +sleeping. When you arrived, your father was + +436 +00:36:27,870 --> 00:36:31,640 +sleeping. He was sleeping. Sorry, you are right. + +437 +00:36:32,120 --> 00:36:35,700 +When you arrived, your father was sleeping. Did + +438 +00:36:35,700 --> 00:36:38,900 +you talk to him when you arrived? No, he was + +439 +00:36:38,900 --> 00:36:43,920 +sleeping. But if you say, when I arrived the other + +440 +00:36:43,920 --> 00:36:48,600 +day, my father had been sleeping. Could you talk + +441 +00:36:48,600 --> 00:36:53,880 +to him on that day? He had been sleeping. Yes, of + +442 +00:36:53,880 --> 00:36:58,380 +course. He had been sleeping. When I arrived, he + +443 +00:36:58,380 --> 00:37:02,460 +had been sleeping. And he opened the door for me + +444 +00:37:02,460 --> 00:37:06,340 +when I arrived. And I talked to him. But when I + +445 +00:37:06,340 --> 00:37:09,540 +arrived, he was sleeping. I could not talk to him. + +446 +00:37:09,980 --> 00:37:18,920 +He was sleeping. Read please + +447 +00:37:18,920 --> 00:37:19,880 +the other sentence. + +448 +00:37:22,750 --> 00:37:26,190 +Her hair was still wet because she had been + +449 +00:37:26,190 --> 00:37:32,010 +swimming. Very good. Now, Mona got home. Her hair + +450 +00:37:32,010 --> 00:37:38,590 +was still wet. Why? She had been swimming. She had + +451 +00:37:38,590 --> 00:37:44,710 +been swimming. Now, got home and had been + +452 +00:37:44,710 --> 00:37:49,410 +swimming. Was this action completed when the other + +453 +00:37:49,410 --> 00:37:54,980 +action started? Yes. Was it completed? Yes, of + +454 +00:37:54,980 --> 00:38:00,820 +course it was completed. But when? Which past? + +455 +00:38:03,620 --> 00:38:07,940 +Thank you. In the immediate past. Very good. There + +456 +00:38:07,940 --> 00:38:13,260 +was a short time, just before. Still, her hair was + +457 +00:38:13,260 --> 00:38:16,300 +wet. Okay, read please the other sentence. + +458 +00:38:21,250 --> 00:38:24,710 +Funeral, yeah? Yes, his eyes were red because he + +459 +00:38:24,710 --> 00:38:27,410 +had been crying. Good, thank you. He had been + +460 +00:38:27,410 --> 00:38:31,510 +crying. When you went to him, he was not crying, + +461 +00:38:31,650 --> 00:38:35,090 +okay? But he had been crying before you went to + +462 +00:38:35,090 --> 00:38:37,670 +him. And you could see what? His eyes were red. + +463 +00:38:37,690 --> 00:38:40,870 +The red eyes. Yes. You could see the red eyes. + +464 +00:38:41,330 --> 00:38:45,470 +Yeah, please read. Distance also may express an + +465 +00:38:45,470 --> 00:38:47,930 +activity in a progressive closing time to another + +466 +00:38:47,930 --> 00:38:50,420 +activity. All the time in the past. Very good. + +467 +00:38:50,840 --> 00:38:54,440 +Okay. Activity in progress. A clause in time to + +468 +00:38:54,440 --> 00:38:58,760 +another activity. When she got home, she had been + +469 +00:38:58,760 --> 00:39:02,620 +sleeping. She had been swimming. A clause in time + +470 +00:39:02,620 --> 00:39:05,600 +to the other activity. I have two activities. The + +471 +00:39:05,600 --> 00:39:13,080 +other one is a clause in time. Now, read. Yes, + +472 +00:39:13,160 --> 00:39:13,400 +please. + +473 +00:39:21,850 --> 00:39:26,610 +Thank you very much. Again, this tense is also + +474 +00:39:26,610 --> 00:39:29,550 +used in the reported speech. Yeah, you want to + +475 +00:39:29,550 --> 00:39:32,590 +ask? Uh-huh, you want to ask? + +476 +00:39:37,110 --> 00:39:42,610 +Now, let's sum up quickly. What did we say about + +477 +00:39:42,610 --> 00:39:45,980 +the past perfect progressive? What did we say? + +478 +00:39:46,720 --> 00:39:51,320 +Yeah, who can give me something? Give me a point. + +479 +00:39:52,700 --> 00:39:55,720 +What did we say about the progressive? Pass + +480 +00:39:55,720 --> 00:40:00,360 +perfect + +481 +00:40:00,360 --> 00:40:01,400 +to progressive, yeah? + +482 +00:40:05,950 --> 00:40:08,530 +Okay, we are interested in the duration. There was + +483 +00:40:08,530 --> 00:40:12,910 +a duration, they were in a progress before another + +484 +00:40:12,910 --> 00:40:15,690 +action happened. Very good, thank you. Yes? + +485 +00:40:19,830 --> 00:40:24,250 +Very good, + +486 +00:40:24,370 --> 00:40:29,250 +thank you very much. Yes, please, Lama? It's much + +487 +00:40:29,250 --> 00:40:32,550 +better to progress when we talk about + +488 +00:40:35,380 --> 00:40:38,220 +Okay. It is used in the reported speech also. + +489 +00:40:38,340 --> 00:40:39,580 +Thank you. Yes, please. + +490 +00:40:43,160 --> 00:40:46,020 +Okay. Thank you. Emphasizes the action you mean. + +491 +00:40:46,520 --> 00:40:49,900 +Thank you. Good. Good. You remember when we talked + +492 +00:40:49,900 --> 00:40:53,000 +about the present perfect progressive and the + +493 +00:40:53,000 --> 00:40:57,800 +present perfect? Okay. Which tense tells us or + +494 +00:40:57,800 --> 00:41:00,040 +emphasizes the result, not the action? The + +495 +00:41:00,040 --> 00:41:01,260 +progressive or the perfect? + +496 +00:41:04,000 --> 00:41:08,000 +Yeah, the perfect. And the progressive emphasizes + +497 +00:41:08,000 --> 00:41:11,120 +the action. Emphasizes I'm interested in the + +498 +00:41:11,120 --> 00:41:14,000 +action more than the result when I use the + +499 +00:41:14,000 --> 00:41:16,480 +progressive. Okay, thank you very much. + diff --git a/PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/3ArZ8qYE-T8_postprocess.srt b/PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/3ArZ8qYE-T8_postprocess.srt new file mode 100644 index 0000000000000000000000000000000000000000..bdfa5fd04ae55475ffe069b3b3e7b99ff5fba25b --- /dev/null +++ b/PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/3ArZ8qYE-T8_postprocess.srt @@ -0,0 +1,2000 @@ +1 +00:00:20,550 --> 00:00:26,150 +Good morning to you all. How are you? Good. + +2 +00:00:30,610 --> 00:00:33,410 +Look at Dua. What is she doing? + +3 +00:00:36,330 --> 00:00:42,710 +What is she doing? She? Yes. Who's speaking? Who's + +4 +00:00:42,710 --> 00:00:46,730 +speaking? Yeah. She's writing. Thank you very + +5 +00:00:46,730 --> 00:00:51,240 +much. Good. Yeah. She's sitting in the class. + +6 +00:00:51,320 --> 00:00:55,900 +Thank you. Good. She's writing. She's looking. + +7 +00:00:56,720 --> 00:01:00,460 +Okay. She's writing. She's sitting. Which tense is + +8 +00:01:00,460 --> 00:01:05,240 +used? Which? One speaker, please. One speaker. + +9 +00:01:05,380 --> 00:01:10,420 +Yeah. Present progressive. Okay. We use the + +10 +00:01:10,420 --> 00:01:14,340 +present progressive to talk about an action. An + +11 +00:01:14,340 --> 00:01:15,460 +action. Yes. + +12 +00:01:18,400 --> 00:01:30,440 +Present progressive okay action + +13 +00:01:30,440 --> 00:01:34,720 +going on yes it started in the past and going on + +14 +00:01:34,720 --> 00:01:39,800 +now thank you very much good now i'm writing i'm + +15 +00:01:39,800 --> 00:01:43,600 +going i'm playing i'm watching i'm eating this is + +16 +00:01:43,600 --> 00:01:50,820 +present progressive What are you doing Nada? I'm + +17 +00:01:50,820 --> 00:01:53,680 +sitting at my desk. Talk about yourself right now. + +18 +00:01:53,880 --> 00:01:57,660 +I'm sitting at my desk. I'm sitting at my desk. Is + +19 +00:01:57,660 --> 00:02:02,840 +she still sitting? Yes, she is still sitting. + +20 +00:02:03,360 --> 00:02:06,940 +She's still listening. Lama, how long have you + +21 +00:02:06,940 --> 00:02:09,820 +been leaving your house? What time is it? Look at + +22 +00:02:09,820 --> 00:02:15,200 +the time. Okay, it's eight o'clock. How long have + +23 +00:02:15,200 --> 00:02:16,660 +you been leaving your house? + +24 +00:02:19,400 --> 00:02:23,480 +Just a minute. How long have you been leaving your + +25 +00:02:23,480 --> 00:02:23,840 +house? + +26 +00:02:26,760 --> 00:02:32,920 +Leaving? Very good. Thank you. And what about you + +27 +00:02:32,920 --> 00:02:35,420 +Basma? How long have you been leaving your house? + +28 +00:02:39,370 --> 00:02:42,850 +For 30 minutes. Thank you. Good. What about you, + +29 +00:02:42,910 --> 00:02:45,310 +Dina? How long have you been leaving your house? + +30 +00:02:49,070 --> 00:02:53,610 +Thank you. And Shayma? I have been leaving? + +31 +00:02:56,350 --> 00:03:01,030 +Okay. Four hours. Thank you. I have been leaving. + +32 +00:03:01,730 --> 00:03:07,830 +Where is she now? Is she at home? No. So, have + +33 +00:03:07,830 --> 00:03:13,270 +been leaving. Have been leaving. Who can comment + +34 +00:03:13,270 --> 00:03:18,310 +on the action? Have been leaving. Nada. This + +35 +00:03:18,310 --> 00:03:23,770 +action began in the past and continued in the + +36 +00:03:23,770 --> 00:03:29,190 +present. Thank you. Started in the past, continued + +37 +00:03:29,190 --> 00:03:35,730 +up to now andand may continue to the future. Okay. + +38 +00:03:36,090 --> 00:03:40,330 +Thank you. That's nice. Could you please read this + +39 +00:03:40,330 --> 00:03:45,790 +example? Yes, please. I have been sitting at my + +40 +00:03:45,790 --> 00:03:47,470 +desk since seven o'clock. + +41 +00:03:50,870 --> 00:03:54,470 +I have been sitting here for two hours. Thank you. + +42 +00:03:55,130 --> 00:04:00,420 +Good. Look, I'm sitting. I have been sitting.I'm + +43 +00:04:00,420 --> 00:04:06,380 +sitting again talks about activity going on now + +44 +00:04:06,380 --> 00:04:10,320 +yes in a progress now at the time of speaking have + +45 +00:04:10,320 --> 00:04:19,020 +been have been sitting the action yes jihad thank + +46 +00:04:19,020 --> 00:04:24,680 +you very much started in the past still and may + +47 +00:04:24,680 --> 00:04:29,450 +continue to the future good thank you now What do + +48 +00:04:29,450 --> 00:04:32,730 +we call this tense? I have been sitting. She has + +49 +00:04:32,730 --> 00:04:38,650 +been leaving. She has been leaving. Very good. So + +50 +00:04:38,650 --> 00:04:41,030 +what's the main difference? Look, present + +51 +00:04:41,030 --> 00:04:45,630 +progressive and present perfect progressive. The + +52 +00:04:45,630 --> 00:04:48,870 +main difference between the present progressive + +53 +00:04:48,870 --> 00:04:52,210 +and the perfect progressive. Najwa. Present + +54 +00:04:52,210 --> 00:04:53,250 +perfect progressive. + +55 +00:04:58,160 --> 00:04:59,880 +Okay. Okay. + +56 +00:05:02,980 --> 00:05:07,620 +So present progressive happening now and perfect + +57 +00:05:07,620 --> 00:05:13,020 +progressive started in the past going on. Thank + +58 +00:05:13,020 --> 00:05:15,620 +you. That's wonderful. Could you please read the + +59 +00:05:15,620 --> 00:05:18,540 +example? Yeah. + +60 +00:05:25,570 --> 00:05:30,890 +Thank you. It's, this is what? It has. Good. It + +61 +00:05:30,890 --> 00:05:34,790 +has been raining all day. It's still raining right + +62 +00:05:34,790 --> 00:05:40,490 +now. Okay. It is still. Very good. It is still + +63 +00:05:40,490 --> 00:05:44,570 +raining. What do you understand from the sentence? + +64 +00:05:46,790 --> 00:05:50,950 +It has been, it's been raining all day. Can we go + +65 +00:05:50,950 --> 00:05:58,210 +walking? No. Can we go walking again? Why not? The + +66 +00:05:58,210 --> 00:06:02,770 +action is still, the action is continuous, still + +67 +00:06:02,770 --> 00:06:07,470 +going on. Now look, why did we you? Now if you + +68 +00:06:07,470 --> 00:06:11,650 +look at, okay, it is still raining. So again, the + +69 +00:06:11,650 --> 00:06:16,730 +action, we say all day, all day, since the + +70 +00:06:16,730 --> 00:06:22,160 +morning. For a long time. It has been raining all + +71 +00:06:22,160 --> 00:06:26,240 +day. What do you understand from this phrase when + +72 +00:06:26,240 --> 00:06:31,260 +I say all day? What does it give you? Yeah. What + +73 +00:06:31,260 --> 00:06:34,980 +does it tell you? What does it tell you? Yeah. + +74 +00:06:37,510 --> 00:06:40,710 +Okay, thank you. It can be used to tell you that + +75 +00:06:40,710 --> 00:06:45,270 +the time is still what? The action is still + +76 +00:06:45,270 --> 00:06:49,690 +happening, going on. The continuity of the action. + +77 +00:06:50,090 --> 00:06:54,270 +Other expressions are also used since for all day, + +78 +00:06:54,410 --> 00:06:58,510 +all morning, all week. She has been sitting at + +79 +00:06:58,510 --> 00:07:03,330 +home all week. She is ill. Okay? She has been + +80 +00:07:03,330 --> 00:07:07,470 +sitting at home all week. She is ill. Now, can you + +81 +00:07:07,470 --> 00:07:11,370 +give me some examples using the present perfect + +82 +00:07:11,370 --> 00:07:14,010 +progressive? Talking about yourself. + +83 +00:07:17,650 --> 00:07:23,430 +Yes? I have been eating my meal at my table since + +84 +00:07:23,430 --> 00:07:28,070 +six o'clock. She has been eating her meal since + +85 +00:07:28,070 --> 00:07:31,880 +what? Six o'clock. Now, it means that you are + +86 +00:07:31,880 --> 00:07:34,280 +still eating now and you are having the food with + +87 +00:07:34,280 --> 00:07:38,400 +you. Okay, good. That's nice. Thank you. Now, her + +88 +00:07:38,400 --> 00:07:44,400 +sister is getting married next week. They have + +89 +00:07:44,400 --> 00:07:49,840 +been preparing for the party since a month. Okay. + +90 +00:07:50,220 --> 00:07:53,160 +They have been preparing for the party since a + +91 +00:07:53,160 --> 00:07:55,860 +month. Yes, go on. Go on. Think of other examples. + +92 +00:07:56,640 --> 00:07:57,260 +Yes, please. + +93 +00:08:01,850 --> 00:08:05,930 +Thank you. She has been going to school since six + +94 +00:08:05,930 --> 00:08:07,050 +o'clock. Good. Yeah. + +95 +00:08:10,370 --> 00:08:15,750 +Since seven o'clock. Talk about yourself. Talk + +96 +00:08:15,750 --> 00:08:18,770 +about yourself, please. I have been teaching + +97 +00:08:18,770 --> 00:08:24,610 +English since 1984. I started still and may + +98 +00:08:24,610 --> 00:08:30,380 +continue, right? Talk about yourself. Yeah. I have + +99 +00:08:30,380 --> 00:08:35,400 +been taking a holiday since three years. I have + +100 +00:08:35,400 --> 00:08:38,420 +been taking a holiday since three years. What do + +101 +00:08:38,420 --> 00:08:39,700 +you mean? Can you explain? + +102 +00:08:42,760 --> 00:08:50,010 +I have a holiday for three days. Three days. Okay. + +103 +00:08:50,650 --> 00:08:53,890 +But you know, look at this example. Just a minute. + +104 +00:08:54,530 --> 00:08:59,010 +You mean the weekend. Okay, good. Now let's talk + +105 +00:08:59,010 --> 00:09:03,130 +about the weekend. Is the weekend, is the holiday + +106 +00:09:03,130 --> 00:09:07,010 +still going on? So how can we express it? Shima + +107 +00:09:07,010 --> 00:09:16,010 +again. Shima. Shall I say, i have been enjoying or + +108 +00:09:16,010 --> 00:09:19,890 +i have enjoyed which is right i have enjoyed or + +109 +00:09:19,890 --> 00:09:26,830 +have been enjoying i enjoyed good it is a + +110 +00:09:26,830 --> 00:09:29,950 +completed action thank you it is a completed + +111 +00:09:29,950 --> 00:09:33,110 +action good yeah i have been studying at + +112 +00:09:33,110 --> 00:09:36,670 +university since two years i still study Very + +113 +00:09:36,670 --> 00:09:40,790 +good. I have been studying for two years. I'm + +114 +00:09:40,790 --> 00:09:44,150 +still studying. Thank you. أحلام. I have been + +115 +00:09:44,150 --> 00:09:47,610 +studying English for 13 years. I have been + +116 +00:09:47,610 --> 00:09:50,490 +studying English for 13 years. Thank you very + +117 +00:09:50,490 --> 00:09:55,010 +much. I'm still studying. Good. We talked about + +118 +00:09:55,010 --> 00:09:56,790 +this, right? Okay. + +119 +00:09:59,790 --> 00:10:02,750 +Would you read the example? Read the example, + +120 +00:10:02,930 --> 00:10:06,320 +please. I have known Ali since he was a child. I + +121 +00:10:06,320 --> 00:10:10,680 +have known Ali since he was a child. I have known + +122 +00:10:10,680 --> 00:10:13,580 +Ali since he was a child. I have known Ali since + +123 +00:10:18,380 --> 00:10:24,180 +I have known Ali since he was a child. I have + +124 +00:10:24,180 --> 00:10:26,040 +known Ali since he was a child. I have known Ali + +125 +00:10:26,040 --> 00:10:26,720 +since he was a child. I have known Ali since he + +126 +00:10:26,720 --> 00:10:29,040 +was a child. I have known Ali since he was a + +127 +00:10:29,040 --> 00:10:30,120 +child. I have known Ali since he was a child. I + +128 +00:10:30,120 --> 00:10:30,300 +have known Ali since he was a child. I have known + +129 +00:10:30,300 --> 00:10:31,000 +Ali since he was a child. I have known Ali since + +130 +00:10:31,000 --> 00:10:31,140 +he was a child. I have known Ali since he was a + +131 +00:10:31,140 --> 00:10:32,640 +Ali since he was a child. I have known Ali And + +132 +00:10:32,640 --> 00:10:35,780 +completed in the past. Just a minute. You know, + +133 +00:10:35,960 --> 00:10:40,980 +okay. Started in the past. I have known. I have + +134 +00:10:40,980 --> 00:10:45,040 +known this friend. I have known. Still. Okay. So + +135 +00:10:45,040 --> 00:10:51,000 +the action started in the past. Going on. And may + +136 +00:10:51,000 --> 00:10:55,420 +continue. So this is, why didn't I use the + +137 +00:10:55,420 --> 00:10:59,700 +progressive? Look, it has been raining all day. I + +138 +00:10:59,700 --> 00:11:04,250 +have been sitting. since nine o'clock. She has + +139 +00:11:04,250 --> 00:11:09,250 +been leaving her school for a long time. Why did + +140 +00:11:09,250 --> 00:11:13,110 +not we use, look this is, why didn't we use the + +141 +00:11:13,110 --> 00:11:17,250 +progressive ing form? Nada. Because it's non + +142 +00:11:17,250 --> 00:11:19,790 +-progressive verb. Very good, thank you very much. + +143 +00:11:19,950 --> 00:11:23,710 +It is a non-progressive verb. A non-progressive + +144 +00:11:23,710 --> 00:11:27,570 +verb. So I cannot say, I have been knowing Ali. + +145 +00:11:27,910 --> 00:11:32,870 +This is not accepted. Okay? We use the ING with + +146 +00:11:32,870 --> 00:11:38,470 +what? With action verbs. With action verbs. Non + +147 +00:11:38,470 --> 00:11:44,160 +-action verbs. Stative verbs. Okay? We don't use + +148 +00:11:44,160 --> 00:11:47,540 +ing and we can have the same result. The same + +149 +00:11:47,540 --> 00:11:51,660 +meaning is expressed by these verbs. The same + +150 +00:11:51,660 --> 00:11:57,480 +result and meaning can be expressed. Read please + +151 +00:11:57,480 --> 00:12:03,020 +the question. Yes Marwa, read the example. How + +152 +00:12:03,020 --> 00:12:05,620 +long have you been living here? How long have you + +153 +00:12:05,620 --> 00:12:09,020 +lived here? Okay. How long have you been living + +154 +00:12:09,020 --> 00:12:12,650 +and how long have you lived? What do you think? + +155 +00:12:12,730 --> 00:12:14,970 +Which tenses are used in the two sentences? + +156 +00:12:21,270 --> 00:12:25,170 +Very good. Present perfect to progressive. Okay. + +157 +00:12:25,830 --> 00:12:30,210 +And in the other one? Present perfect. Thank you. + +158 +00:12:30,950 --> 00:12:33,890 +Now, which is right to say, I have lived in Gaza + +159 +00:12:33,890 --> 00:12:37,990 +for 10 years or I have been living in Gaza for 10 + +160 +00:12:37,990 --> 00:12:42,610 +years? Murida. Okay, the first one, no, no. The + +161 +00:12:42,610 --> 00:12:46,370 +correct one is I have been living in Gaza for two + +162 +00:12:46,370 --> 00:12:52,530 +years or more. But the first one in the cover, we + +163 +00:12:52,530 --> 00:12:57,750 +have been living in Gaza since a year, for + +164 +00:12:57,750 --> 00:13:01,890 +example. But it means that we have been living and + +165 +00:13:01,890 --> 00:13:04,130 +we may continue living. + +166 +00:13:10,840 --> 00:13:15,060 +Okay, thank you very much could you please read + +167 +00:13:15,060 --> 00:13:18,740 +what is written here read this sentence read it + +168 +00:13:21,260 --> 00:13:23,660 +The two sentences have the same meaning. Thank you + +169 +00:13:23,660 --> 00:13:27,280 +for your answer. Okay? The two sentences. So + +170 +00:13:27,280 --> 00:13:31,020 +sometimes, sometimes the perfect and the + +171 +00:13:31,020 --> 00:13:35,400 +progressive, okay? Sometimes, not always, they + +172 +00:13:35,400 --> 00:13:39,660 +meet in certain points. You can express, you can + +173 +00:13:39,660 --> 00:13:43,760 +use some verbs, okay? To express certain + +174 +00:13:43,760 --> 00:13:47,320 +situations using the perfect progressive or the + +175 +00:13:47,320 --> 00:13:51,450 +symbol, the present perfect. And sometimes there + +176 +00:13:51,450 --> 00:13:55,990 +are some differences between the two tenses. With + +177 +00:13:55,990 --> 00:13:59,850 +live, if you want to use live for example, you can + +178 +00:13:59,850 --> 00:14:03,490 +use the perfect or the progressive to give the + +179 +00:14:03,490 --> 00:14:07,830 +same idea, the same meaning. Is that okay? Could + +180 +00:14:07,830 --> 00:14:12,170 +you please read the other sentence please? Ali has + +181 +00:14:12,170 --> 00:14:15,710 +been wearing glasses since he was ten. Ali has + +182 +00:14:15,710 --> 00:14:18,960 +worn glasses since he was ten. The two sentences + +183 +00:14:18,960 --> 00:14:21,020 +have the same meaning. Thank you very much. What + +184 +00:14:21,020 --> 00:14:24,320 +does that mean? What does, what do you understand? + +185 +00:14:24,400 --> 00:14:26,820 +The two sentences have the same meaning. + +186 +00:14:29,440 --> 00:14:34,940 +You mean, yeah, the progressive and the perfect. + +187 +00:14:35,260 --> 00:14:42,790 +Okay. Also with this verb. Yes. Where? give the + +188 +00:14:42,790 --> 00:14:46,010 +same meaning you can use if you want to express a + +189 +00:14:46,010 --> 00:14:48,950 +certain situation with this verb the progressive + +190 +00:14:48,950 --> 00:14:52,590 +and the perfect the simple perfect have the same + +191 +00:14:52,590 --> 00:14:56,070 +meaning now + +192 +00:14:56,070 --> 00:15:00,610 +look at this example could you read it please yeah + +193 +00:15:00,610 --> 00:15:06,570 +i have lived in gaza my + +194 +00:15:06,570 --> 00:15:07,690 +whole life + +195 +00:15:15,810 --> 00:15:20,110 +This is the meaning. Thank you. Now, when I say I + +196 +00:15:20,110 --> 00:15:25,450 +have lived in Gaza my whole life or I have been + +197 +00:15:25,450 --> 00:15:30,670 +living in Gaza my whole life. Okay. What do you + +198 +00:15:30,670 --> 00:15:35,460 +understand? If somebody tells you, I have lived or + +199 +00:15:35,460 --> 00:15:40,460 +I have been living, that I was born in Gaza and I + +200 +00:15:40,460 --> 00:15:44,540 +am still. This meaning can be indicated from the + +201 +00:15:44,540 --> 00:15:48,180 +first sentence and from the second sentence. Okay? + +202 +00:15:49,000 --> 00:15:51,620 +In the first sentence, which tense did we use? + +203 +00:15:53,700 --> 00:15:57,700 +Good. And in the second sentence? Prison, perfect, + +204 +00:15:57,940 --> 00:16:01,300 +progressive. Now, the two sentences talk about + +205 +00:16:01,300 --> 00:16:04,060 +things started in the past, continue up to the + +206 +00:16:04,060 --> 00:16:06,980 +present, and may continue to the future. + +207 +00:16:11,640 --> 00:16:17,640 +The two + +208 +00:16:17,640 --> 00:16:21,780 +sentences. Now, she wants to say something. She + +209 +00:16:21,780 --> 00:16:27,670 +wants to comment, as if she wants to ask. Okay? We + +210 +00:16:27,670 --> 00:16:30,310 +talked about the present perfect and the present + +211 +00:16:30,310 --> 00:16:32,710 +perfect progressive. We are talking about the + +212 +00:16:32,710 --> 00:16:39,330 +progressive. In general, they are used to express + +213 +00:16:39,330 --> 00:16:43,850 +an action started in the past, they meet in this + +214 +00:16:43,850 --> 00:16:49,850 +point, still going on and may continue. When you + +215 +00:16:49,850 --> 00:16:55,770 +say, I have left, it means that Yeah. I have + +216 +00:16:55,770 --> 00:17:00,830 +taught. It means that started, still and continue. + +217 +00:17:01,550 --> 00:17:09,590 +Now, the two sentences meet in this point. Okay? + +218 +00:17:09,850 --> 00:17:13,050 +Started in the past, still going on and may + +219 +00:17:13,050 --> 00:17:16,090 +continue. Especially with some verbs. With some + +220 +00:17:16,090 --> 00:17:20,750 +verbs. This is another example, live. So there is + +221 +00:17:20,750 --> 00:17:25,470 +no difference now if you express The situation + +222 +00:17:25,470 --> 00:17:29,410 +using the first sentence the first structure or + +223 +00:17:29,410 --> 00:17:31,930 +the other structure it will give you the same + +224 +00:17:31,930 --> 00:17:36,710 +meaning Now + +225 +00:17:36,710 --> 00:17:48,050 +I who wants to read yes, please Yeah, + +226 +00:17:48,150 --> 00:17:56,290 +how long how long My whole life. Okay? Yeah. So + +227 +00:17:56,290 --> 00:18:01,290 +I'm expressing how long. Yeah, go on, please. The + +228 +00:18:01,290 --> 00:18:05,370 +present perfect progressive or the present + +229 +00:18:05,370 --> 00:18:08,310 +perfect. Thank you. Either tense can be used only + +230 +00:18:08,310 --> 00:18:12,190 +when the verb expresses the duration of the + +231 +00:18:12,190 --> 00:18:15,890 +present activities or situations that happen + +232 +00:18:15,890 --> 00:18:22,150 +regularly, usually, habitually. For example, work, + +233 +00:18:22,330 --> 00:18:25,890 +teach, study, wear, nice dress, play, nature. + +234 +00:18:26,390 --> 00:18:29,390 +Thank you. So with these verbs, you can use the + +235 +00:18:29,390 --> 00:18:34,930 +perfect progressive, okay? Or we can use what? The + +236 +00:18:34,930 --> 00:18:38,990 +present perfect. Now look, we use them when the + +237 +00:18:38,990 --> 00:18:42,230 +verb expresses the duration of a present activity + +238 +00:18:42,230 --> 00:18:47,150 +or situation. I have left. I have been living. + +239 +00:18:47,960 --> 00:18:53,660 +Okay? Can be expressed in either tense. Read + +240 +00:18:53,660 --> 00:18:56,700 +please the other example. I have been living in + +241 +00:18:56,700 --> 00:19:00,400 +this flat for three years. But next month I am + +242 +00:19:00,400 --> 00:19:04,580 +moving to a new villa. Good. Thank you. Just a + +243 +00:19:04,580 --> 00:19:06,540 +minute. Just a minute. Thank you. This is enough. + +244 +00:19:07,000 --> 00:19:12,140 +I have been living in this flat for three years. I + +245 +00:19:12,140 --> 00:19:16,140 +have been living. Is the action still going on? + +246 +00:19:17,400 --> 00:19:21,120 +Yes, yes. One speaker. + +247 +00:19:21,580 --> 00:19:25,360 +Who's the speaker? Yeah? No, because he moves to a + +248 +00:19:25,360 --> 00:19:29,980 +new country. He moves? Okay. Just a minute, + +249 +00:19:30,180 --> 00:19:35,140 +please, please. Just a minute. What, what time are + +250 +00:19:35,140 --> 00:19:40,760 +you leaving the university today? At one. Say, I + +251 +00:19:40,760 --> 00:19:43,660 +am leaving. I'm leaving the university. Just a + +252 +00:19:43,660 --> 00:19:48,350 +minute. She's speaking. Yeah. I'm leaving the + +253 +00:19:48,350 --> 00:19:51,990 +university at one. We use the progressive to + +254 +00:19:51,990 --> 00:19:56,790 +express what? The future. So the progressive, I'm + +255 +00:19:56,790 --> 00:20:01,630 +leaving at one. The progressive is used here to + +256 +00:20:01,630 --> 00:20:05,950 +express the future. Now in this sentence, okay, + +257 +00:20:06,530 --> 00:20:09,550 +I'm leaving. Next month, I'm leaving. I'm moving + +258 +00:20:09,550 --> 00:20:16,270 +to a new villa. Is she still living? Yes. Who says + +259 +00:20:16,270 --> 00:20:22,630 +no? Just a minute. Who says no? You said no? Why? + +260 +00:20:22,730 --> 00:20:24,050 +How did you understand that? + +261 +00:20:27,530 --> 00:20:31,150 +Okay, the next month. Okay, good. This is future + +262 +00:20:31,150 --> 00:20:35,550 +time. This is future time. Where is she living + +263 +00:20:35,550 --> 00:20:43,330 +now? Okay, so the action started + +264 +00:20:45,050 --> 00:20:48,850 +Okay, and still, it's still going on. The action + +265 +00:20:48,850 --> 00:20:57,910 +did not stop. It is still going on. Okay. Now, is + +266 +00:20:57,910 --> 00:21:03,110 +this verb or what do you understand? Is she living + +267 +00:21:03,110 --> 00:21:07,750 +for a long time or for a short time? In other + +268 +00:21:07,750 --> 00:21:10,610 +words, temporary action or permanent action? + +269 +00:21:11,550 --> 00:21:17,050 +Temporary action. Again. Who wants to say + +270 +00:21:17,050 --> 00:21:21,890 +something? Who wants to say something? Yes, + +271 +00:21:22,030 --> 00:21:30,250 +comment. Yes, please. Very good. So the present + +272 +00:21:30,250 --> 00:21:34,270 +perfect progressive also can be used to express + +273 +00:21:34,270 --> 00:21:40,790 +what? Okay. Look, she always sits in the front. + +274 +00:21:41,600 --> 00:21:46,420 +Okay, but today she is sitting in the back. How + +275 +00:21:46,420 --> 00:21:51,180 +can you express that action? You usually come + +276 +00:21:51,180 --> 00:21:54,480 +here. I see you in the front classes, right? Okay, + +277 +00:21:54,880 --> 00:21:57,860 +seats. So how would you express this situation + +278 +00:21:57,860 --> 00:21:59,080 +using uh-huh? + +279 +00:22:01,980 --> 00:22:02,700 +Okay, + +280 +00:22:05,940 --> 00:22:06,460 +thank you. + +281 +00:22:11,520 --> 00:22:14,640 +Yes, would you read lemma please? I have. I have + +282 +00:22:14,640 --> 00:22:17,300 +been thinking about looking for a different job. + +283 +00:22:17,620 --> 00:22:20,880 +This one doesn't pay enough. Aha, good. I have + +284 +00:22:20,880 --> 00:22:25,180 +been thinking. Is it a temporary or a permanent? + +285 +00:22:25,880 --> 00:22:30,660 +Temporary. Who's the speaker? Who's the speaker? + +286 +00:22:30,840 --> 00:22:33,000 +Yeah? The speaker actually. Good. How did you + +287 +00:22:33,000 --> 00:22:38,030 +know? I'm looking. Okay. Uh, yes, I'm looking for + +288 +00:22:38,030 --> 00:22:41,310 +a different job. Okay. So I'm just, I'm not + +289 +00:22:41,310 --> 00:22:45,170 +staying forever in this job. Now the other one. + +290 +00:22:45,570 --> 00:22:46,990 +Yes. The other one, please. + +291 +00:22:50,390 --> 00:22:57,230 +Thank you. Have been studying. Final exams start + +292 +00:22:57,230 --> 00:23:01,230 +next week. I have been thinking and all the + +293 +00:23:01,230 --> 00:23:05,490 +students have been studying. When the tense is + +294 +00:23:05,490 --> 00:23:10,710 +used without any mention of time. Look. Did we say + +295 +00:23:10,710 --> 00:23:14,730 +for example since or for? No. Did we mention any + +296 +00:23:14,730 --> 00:23:19,120 +reference to time? No. Okay. Now, when the tense + +297 +00:23:19,120 --> 00:23:21,920 +is used without any mention of time, it expresses + +298 +00:23:21,920 --> 00:23:26,640 +what? A general activity. Okay? In a progress + +299 +00:23:26,640 --> 00:23:30,020 +recently. For example, I have been thinking + +300 +00:23:30,020 --> 00:23:35,980 +lately. The students have been studying these days + +301 +00:23:35,980 --> 00:23:40,990 +because the exams are coming. if you want to + +302 +00:23:40,990 --> 00:23:45,530 +express a general activity a general activity + +303 +00:23:45,530 --> 00:23:51,190 +don't mention a specific or don't refer to time no + +304 +00:23:51,190 --> 00:23:56,050 +need to mention any time expressions okay yeah + +305 +00:23:56,050 --> 00:24:00,590 +what do you mean by general activity? general all + +306 +00:24:00,590 --> 00:24:04,190 +people for example if i talk about okay the + +307 +00:24:04,190 --> 00:24:08,520 +students okay all of the students all of the + +308 +00:24:08,520 --> 00:24:11,320 +students am i talking about a certain group of + +309 +00:24:11,320 --> 00:24:15,640 +students or all of the students all of the + +310 +00:24:15,640 --> 00:24:20,020 +students so in general they are engaged they are + +311 +00:24:20,020 --> 00:24:24,060 +busy in a certain activity after some weeks if you + +312 +00:24:24,060 --> 00:24:26,620 +look at the university all the students will be + +313 +00:24:26,620 --> 00:24:29,820 +looking at their box because they will be having + +314 +00:24:29,820 --> 00:24:34,020 +exams Okay? And this is a general activity. Every + +315 +00:24:34,020 --> 00:24:39,760 +body, almost everyone is engaged in this activity. + +316 +00:24:40,340 --> 00:24:44,680 +Don't use time reference. Okay? In this case. + +317 +00:24:52,740 --> 00:24:55,040 +Would you read the other example, please? + +318 +00:24:59,160 --> 00:25:04,040 +Okay, thank you. I have been reading a book on + +319 +00:25:04,040 --> 00:25:13,380 +wild animals. Okay, and I, yeah? I have read a + +320 +00:25:13,380 --> 00:25:16,440 +book on wild animals. Good, thank you very much. + +321 +00:25:17,240 --> 00:25:21,380 +Now, I have been reading and I have read. What do + +322 +00:25:21,380 --> 00:25:26,180 +you think is the difference between the two + +323 +00:25:26,180 --> 00:25:28,220 +tenses? What do you think? + +324 +00:25:35,200 --> 00:25:35,820 +Okay. + +325 +00:25:39,520 --> 00:25:44,540 +So the action is still. The action is still. They + +326 +00:25:44,540 --> 00:25:48,020 +have been writing. They have been sitting. They + +327 +00:25:48,020 --> 00:25:54,140 +have been playing. They have + +328 +00:25:54,140 --> 00:25:58,480 +been building. They have been writing. Okay. Now, + +329 +00:25:58,580 --> 00:26:03,540 +what's that man doing? He has been recording. + +330 +00:26:03,840 --> 00:26:08,920 +Okay? So again, we say the activity is unfinished. + +331 +00:26:09,040 --> 00:26:12,340 +It's still going on. But if you say, I have + +332 +00:26:12,340 --> 00:26:17,340 +written this report. I have written this story. It + +333 +00:26:17,340 --> 00:26:20,920 +is a complete story now. Okay? Look, I have + +334 +00:26:20,920 --> 00:26:25,250 +written this story. It is a complete story. Okay? + +335 +00:26:25,810 --> 00:26:29,970 +Why are you busy? We don't see you much these + +336 +00:26:29,970 --> 00:26:35,350 +days. I have been writing a story. It means I'm + +337 +00:26:35,350 --> 00:26:38,750 +still writing and I'm busy. I cannot give it to + +338 +00:26:38,750 --> 00:26:43,210 +you to read. The present perfect without for or + +339 +00:26:43,210 --> 00:26:47,270 +since refers to what? Okay, an activity or a + +340 +00:26:47,270 --> 00:26:51,830 +state. That is what? Okay, thank you. + +341 +00:26:55,950 --> 00:26:59,110 +Read the other one, please. She's had three cups + +342 +00:26:59,110 --> 00:27:01,730 +of coffee this morning. + +343 +00:27:09,950 --> 00:27:16,330 +I'm talking about what? Number. She's had. She has + +344 +00:27:16,330 --> 00:27:21,130 +had. Can you give me another verb instead of had? + +345 +00:27:21,330 --> 00:27:25,150 +What does had mean in this sentence? What does had + +346 +00:27:25,150 --> 00:27:27,550 +mean? Who's the speaker? One speaker, please. + +347 +00:27:27,770 --> 00:27:32,330 +Yeah. Drunk. Very good. Drunk. Okay. So she has + +348 +00:27:32,330 --> 00:27:38,110 +drunk three cups of coffee this morning. Okay. We + +349 +00:27:38,110 --> 00:27:41,760 +don't say in this case, she has been having. She + +350 +00:27:41,760 --> 00:27:44,840 +has been drinking three cups of coffee this + +351 +00:27:44,840 --> 00:27:49,380 +morning. Why? Because we don't usually use the + +352 +00:27:49,380 --> 00:27:52,900 +present perfect progressive to talk about how many + +353 +00:27:52,900 --> 00:27:57,000 +times someone has done something or how many + +354 +00:27:57,000 --> 00:28:03,160 +things someone has done. Okay? I say, for example, + +355 +00:28:03,520 --> 00:28:07,640 +I have given two lectures today. I have given two + +356 +00:28:07,640 --> 00:28:13,790 +lectures this morning. I have given I cannot say + +357 +00:28:13,790 --> 00:28:16,610 +or it is not recommended to say, I have been + +358 +00:28:16,610 --> 00:28:20,110 +giving three lectures or two lectures this + +359 +00:28:20,110 --> 00:28:24,670 +morning. So if you want to talk about number of + +360 +00:28:24,670 --> 00:28:29,850 +times, use what? The perfect, not the progressive. + +361 +00:28:30,510 --> 00:28:34,990 +Don't use the progressive. Why do you think? It is + +362 +00:28:34,990 --> 00:28:37,650 +not recommended when we talk about the number of + +363 +00:28:37,650 --> 00:28:40,530 +times not to use the progressive. Why do you + +364 +00:28:40,530 --> 00:28:40,850 +think? + +365 +00:28:43,910 --> 00:28:49,570 +Which one is finished? The perfect. So if you want + +366 +00:28:49,570 --> 00:28:52,290 +to count things, you count things which are + +367 +00:28:52,290 --> 00:28:55,630 +finished, right? But things which are still going + +368 +00:28:55,630 --> 00:28:59,510 +on cannot be counted, right? We cannot count. + +369 +00:28:59,630 --> 00:29:01,230 +Thank you. + +370 +00:29:03,190 --> 00:29:07,750 +Go on, please. Read the sentence. I have been + +371 +00:29:07,750 --> 00:29:12,730 +swimming swimming. That's why my hair is wet. + +372 +00:29:12,810 --> 00:29:13,370 +Thank you. + +373 +00:29:16,970 --> 00:29:21,210 +Thank you + +374 +00:29:21,210 --> 00:29:25,270 +very much. Okay. I have been swimming. Good. I + +375 +00:29:25,270 --> 00:29:31,430 +have been swimming. I have been swimming. Look, is + +376 +00:29:31,430 --> 00:29:37,810 +the action still going on? Yes. Is he or she still + +377 +00:29:37,810 --> 00:29:44,850 +swimming? Yes. No. The action is what? Finished. + +378 +00:29:46,290 --> 00:29:53,150 +Completely finished. The action began in the past. + +379 +00:29:53,330 --> 00:29:56,830 +And when do you think the action stopped or + +380 +00:29:56,830 --> 00:30:00,960 +finished? Very good, thank you very much. Has + +381 +00:30:00,960 --> 00:30:04,840 +just, okay? Has just finished. Look, I have been + +382 +00:30:04,840 --> 00:30:10,160 +swimming. That's why my hair is wet. Okay? It is + +383 +00:30:10,160 --> 00:30:13,240 +in the immediate past. Okay? In the immediate + +384 +00:30:13,240 --> 00:30:19,540 +past. Again, I have been swimming. The action is + +385 +00:30:19,540 --> 00:30:24,920 +completed. I'm not swimming anymore. Okay? But you + +386 +00:30:24,920 --> 00:30:28,410 +can see the result of that. You can see the effect + +387 +00:30:28,410 --> 00:30:34,110 +of swimming. Why are your clothes so dirty? Why + +388 +00:30:34,110 --> 00:30:38,630 +are they so dirty? What have you been doing? What + +389 +00:30:38,630 --> 00:30:42,510 +have you been doing? Your father comes late at + +390 +00:30:42,510 --> 00:30:45,910 +home, for example, with dirty hands and dirty + +391 +00:30:45,910 --> 00:30:50,550 +shirt. You ask him, what's that, dad? He says, I + +392 +00:30:50,550 --> 00:30:54,390 +have been fixing the car. I have been fixing the + +393 +00:30:54,390 --> 00:31:00,750 +car. Is the action still going on? No. The car is + +394 +00:31:00,750 --> 00:31:05,150 +okay at that time, right? But he has still a few + +395 +00:31:05,150 --> 00:31:08,650 +minutes before I go, he finished fixing the car. + +396 +00:31:09,250 --> 00:31:13,290 +So again, we use the present perfect progressive + +397 +00:31:13,290 --> 00:31:19,130 +also to talk about actions which what? Okay. Has + +398 +00:31:19,130 --> 00:31:23,510 +just stopped. Which has just stopped. Okay. Can + +399 +00:31:23,510 --> 00:31:25,070 +you think of similar examples? + +400 +00:31:27,640 --> 00:31:31,320 +Yeah. I have been washing the dishes. That's why + +401 +00:31:31,320 --> 00:31:34,020 +my hands are wet. Very good. I have been washing + +402 +00:31:34,020 --> 00:31:38,480 +the dishes. That's why my hands are wet. My dress + +403 +00:31:38,480 --> 00:31:41,200 +is wet. Thank you very much. Good. Yeah. I've been + +404 +00:31:41,200 --> 00:31:44,140 +surfing the internet all night. That's why my eyes + +405 +00:31:44,140 --> 00:31:47,440 +are red. Very good. I have been surfing the net + +406 +00:31:47,440 --> 00:31:51,120 +all night. That's why my eyes are red. Wonderful. + +407 +00:31:51,440 --> 00:31:56,080 +Good example. Other examples. Other examples. Go + +408 +00:31:56,080 --> 00:32:02,900 +on. Yeah. I have been running daily. My face is + +409 +00:32:02,900 --> 00:32:07,920 +red. I have been running all the way to the + +410 +00:32:07,920 --> 00:32:10,940 +university. She did not have a bus or a taxi. + +411 +00:32:11,600 --> 00:32:16,260 +Okay? So, she has been running. Why your face is + +412 +00:32:16,260 --> 00:32:19,580 +red? I have been running all the way to the + +413 +00:32:19,580 --> 00:32:22,260 +university. It is a good example. Thank you. + +414 +00:32:22,400 --> 00:32:25,220 +Still. Okay? Thank you very much. Good. + +415 +00:32:29,250 --> 00:32:31,770 +This is a similar example. Could you read it + +416 +00:32:31,770 --> 00:32:32,150 +please? + +417 +00:32:37,590 --> 00:32:41,030 +Good. What about the car? Can the car walk now? + +418 +00:32:41,890 --> 00:32:46,010 +Yes, the car is okay. Ali's hands are very dirty. + +419 +00:32:46,150 --> 00:32:50,010 +He has been fixing the car. He has been fixing the + +420 +00:32:50,010 --> 00:32:57,310 +car. The car is okay now. so again yes read again + +421 +00:32:57,310 --> 00:33:03,610 +please dina thank + +422 +00:33:03,610 --> 00:33:08,110 +you thank you just a minute thank you now we have + +423 +00:33:08,110 --> 00:33:12,670 +an action and a result action and effect action + +424 +00:33:12,670 --> 00:33:16,490 +and effect okay which is more important in this + +425 +00:33:16,490 --> 00:33:21,470 +sentence he has been fixing the car the dirty + +426 +00:33:21,470 --> 00:33:27,640 +hands Okay, or the action which is fixing the car. + +427 +00:33:27,840 --> 00:33:32,060 +This is for you. He has been fixed. Okay, so you + +428 +00:33:32,060 --> 00:33:35,200 +mean the action is more important. Thank you. Go + +429 +00:33:35,200 --> 00:33:37,540 +on, please read. We are interested in the action. + +430 +00:33:37,680 --> 00:33:40,000 +It doesn't matter whether something has been + +431 +00:33:40,000 --> 00:33:44,600 +finished or not. Very good. If the action is more, + +432 +00:33:44,700 --> 00:33:47,440 +if we are interested in the action more than the + +433 +00:33:47,440 --> 00:33:51,050 +result, we use the progressive. And if we are + +434 +00:33:51,050 --> 00:33:56,510 +interested in that, I did not complete. Yes, + +435 +00:33:56,630 --> 00:34:04,170 +complete. Very good. Okay. I have cleaned the + +436 +00:34:04,170 --> 00:34:07,030 +house. I have finished my homework. I have + +437 +00:34:07,030 --> 00:34:09,950 +finished my homework. I'm free now. I can do + +438 +00:34:09,950 --> 00:34:13,610 +whatever I like. Okay. I can play. I can go to + +439 +00:34:13,610 --> 00:34:20,640 +bed. I can watch TV and so on. That's it. Now, + +440 +00:34:20,780 --> 00:34:22,280 +could you please close your box? + +441 +00:34:28,860 --> 00:34:34,420 +Open your minds and let's make a summary of what + +442 +00:34:34,420 --> 00:34:38,800 +we said today about what? What were we talking + +443 +00:34:38,800 --> 00:34:41,260 +about today? Yes, Jihan. + +444 +00:34:45,580 --> 00:34:46,180 +Okay, + +445 +00:35:01,680 --> 00:35:04,900 +good. So if we want to differentiate, if somebody + +446 +00:35:04,900 --> 00:35:07,850 +asks you, what's the difference? between the + +447 +00:35:07,850 --> 00:35:10,410 +present perfect and the present perfect + +448 +00:35:10,410 --> 00:35:14,790 +progressive. You say, the perfect starts usually + +449 +00:35:14,790 --> 00:35:22,530 +started in the past, okay? Up to now, yeah? Now + +450 +00:35:22,530 --> 00:35:25,970 +listen, listen, the difference we said, the two + +451 +00:35:25,970 --> 00:35:29,730 +tenses, the progressive and the perfect, the + +452 +00:35:29,730 --> 00:35:33,190 +simple perfect, are used to express an action + +453 +00:35:33,190 --> 00:35:38,200 +started in the past, okay still up to now and may + +454 +00:35:38,200 --> 00:35:42,020 +continue to the future now we said they meet in + +455 +00:35:42,020 --> 00:35:45,020 +this point but there are some differences between + +456 +00:35:45,020 --> 00:35:49,360 +the two chances okay yeah thank you very much for + +457 +00:35:49,360 --> 00:35:55,480 +this point let's talk about that good + +458 +00:35:55,480 --> 00:35:58,740 +thank + +459 +00:35:58,740 --> 00:35:59,500 +you yeah + +460 +00:36:07,550 --> 00:36:13,230 +Okay, thank you they have the same meaning or they + +461 +00:36:13,230 --> 00:36:20,070 +give the same meaning good Very good. Okay, the + +462 +00:36:20,070 --> 00:36:23,450 +progressive is not used with stative verbs or non + +463 +00:36:23,450 --> 00:36:26,390 +action verbs Thank you very much. Good. Yes, + +464 +00:36:26,450 --> 00:36:30,640 +please We don't use the present perfect for + +465 +00:36:30,640 --> 00:36:34,400 +present. We have things because it is finished. + +466 +00:36:34,700 --> 00:36:39,020 +It's not finished. Thank you. Sure. Good. Yes? We + +467 +00:36:39,020 --> 00:36:41,600 +can use the present perfect. For example, in a + +468 +00:36:41,600 --> 00:36:44,980 +children activity, for example, all the students + +469 +00:36:44,980 --> 00:36:52,360 +has been sorry because next day it happens. Okay. + +470 +00:36:52,440 --> 00:37:00,820 +Thank you. Good. Yes, please. Time in + +471 +00:37:00,820 --> 00:37:03,720 +the present perfect progressive, we don't use time + +472 +00:37:03,720 --> 00:37:09,000 +reference. Okay, now can I say I have been talking + +473 +00:37:09,000 --> 00:37:13,320 +about the progressive for 30 minutes. Can I say + +474 +00:37:13,320 --> 00:37:17,680 +that? Yes, so we can use it, but sometimes, + +475 +00:37:17,940 --> 00:37:21,960 +sometimes we don't use, we don't refer to the + +476 +00:37:21,960 --> 00:37:28,120 +time. When? When? In general activities. Okay, + +477 +00:37:28,240 --> 00:37:31,180 +general activities. Good. Thank you. For example, + +478 +00:37:31,820 --> 00:37:37,800 +all the students have been studying hard. Exams + +479 +00:37:37,800 --> 00:37:40,800 +are coming. Thank you. Yeah. We don't choose a + +480 +00:37:40,800 --> 00:37:44,860 +result to express how many things or times someone + +481 +00:37:44,860 --> 00:37:49,180 +has done, but we use a result, a perfect. For + +482 +00:37:49,180 --> 00:37:53,400 +example, I have had two sandwiches in a row. Good. + +483 +00:37:53,500 --> 00:37:56,230 +Thank you very much. Yes, please. We use the + +484 +00:37:56,230 --> 00:38:02,390 +present perfect continuous also to talk about + +485 +00:38:02,390 --> 00:38:05,590 +actions that happened in the past and finished + +486 +00:38:05,590 --> 00:38:12,030 +just now. Very good. For example, I have been + +487 +00:38:12,030 --> 00:38:17,990 +swimming. I have been swimming, okay? My hands are + +488 +00:38:17,990 --> 00:38:24,430 +wet, okay? I have been sleeping.My eyes are red. + +489 +00:38:24,650 --> 00:38:29,570 +She has been running. Her face is red. Good, thank + +490 +00:38:29,570 --> 00:38:33,410 +you. Other points? Yes, please. When we are + +491 +00:38:33,410 --> 00:38:36,030 +interested in action more than result, we use + +492 +00:38:36,030 --> 00:38:39,530 +result perfect. But when we are interested in + +493 +00:38:39,530 --> 00:38:42,550 +action more than result, we use result perfect. + +494 +00:38:42,890 --> 00:38:46,970 +Good. When we are interested in the action more + +495 +00:38:46,970 --> 00:38:50,950 +than the result, we use the progressive. And when + +496 +00:38:50,950 --> 00:38:55,490 +we are interested in the result more than the + +497 +00:38:55,490 --> 00:38:58,070 +action, we use the perfect. Good, thank you. You + +498 +00:38:58,070 --> 00:39:02,830 +want to say something? Yes? Who wants to add + +499 +00:39:02,830 --> 00:39:07,350 +another point? Is that okay? Okay, thank you very + +500 +00:39:07,350 --> 00:39:07,670 +much. + diff --git a/PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/4pb6UpWvYds.srt b/PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/4pb6UpWvYds.srt new file mode 100644 index 0000000000000000000000000000000000000000..c2c8163c233ceaf1af4484670cf23ad3390f5d8e --- /dev/null +++ b/PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/4pb6UpWvYds.srt @@ -0,0 +1,1424 @@ + +1 +00:00:21,190 --> 00:00:26,210 +Good morning to you all. How are you? Did you + +2 +00:00:26,210 --> 00:00:30,070 +enjoy the holiday? I'm fine, thank you. Why not? + +3 +00:00:34,110 --> 00:00:39,750 +Why not? So, you can't say Alhamdulillah. Stop + +4 +00:00:39,750 --> 00:00:42,630 +nagging, complaining, stop complaining. You should + +5 +00:00:42,630 --> 00:00:45,050 +always say Alhamdulillah. Okay. + +6 +00:00:48,610 --> 00:00:49,210 +Now, + +7 +00:00:51,970 --> 00:00:53,910 +We are still talking about nouns. + +8 +00:00:56,650 --> 00:01:01,990 +Nouns can be used with some expressions of a + +9 +00:01:01,990 --> 00:01:08,170 +quantity, and nouns are different. As you know, we + +10 +00:01:08,170 --> 00:01:12,570 +have some singular nouns, singular plural count, + +11 +00:01:13,390 --> 00:01:18,970 +plural count, and we have non-count. How can we + +12 +00:01:18,970 --> 00:01:22,390 +use these nouns with the expressions of a + +13 +00:01:22,390 --> 00:01:30,470 +quantity? Some expressions + +14 +00:01:30,470 --> 00:01:35,090 +can be used only with singular count nouns. Others + +15 +00:01:35,090 --> 00:01:39,410 +can be used with plural. Others can be used with + +16 +00:01:39,410 --> 00:01:46,460 +non-count nouns. Others may be used with more than + +17 +00:01:46,460 --> 00:01:51,280 +one type of nouns. Now, let's see. If you look at + +18 +00:01:51,280 --> 00:01:55,980 +these expressions. Now, Apple. This is what? What + +19 +00:01:55,980 --> 00:02:00,380 +type of noun is it? Singular count. Apple, book. + +20 +00:02:00,740 --> 00:02:07,390 +Okay, student. We can say one. Apple, two. Okay, + +21 +00:02:07,630 --> 00:02:13,250 +sorry, each, apple, every, apple. So now one, each + +22 +00:02:13,250 --> 00:02:16,490 +and every are used with what type of nouns? Yes, + +23 +00:02:17,050 --> 00:02:20,970 +singular count nouns. Thank you very much. And you + +24 +00:02:20,970 --> 00:02:24,670 +know, singular count nouns can be made plural by + +25 +00:02:24,670 --> 00:02:28,810 +adding what is or is. Since we can say one apple, + +26 +00:02:28,930 --> 00:02:32,390 +we can say what? Two apples, three apples and so + +27 +00:02:32,390 --> 00:02:37,710 +on. We can also say what? Both apples, both + +28 +00:02:37,710 --> 00:02:42,650 +students and so on. And we can say a couple of + +29 +00:02:42,650 --> 00:02:48,860 +apples. We can say what? Yes? A few of apples. + +30 +00:02:49,040 --> 00:02:54,780 +Thank you. We can say several, several apples. + +31 +00:02:55,060 --> 00:02:58,600 +Thank you. And we can say many apples. And we can + +32 +00:02:58,600 --> 00:03:03,200 +say what? A number of apples. Now, these + +33 +00:03:03,200 --> 00:03:06,180 +expressions of a quantity, one each, every two, + +34 +00:03:06,360 --> 00:03:11,530 +and, and, okay, are always used with what? With + +35 +00:03:11,530 --> 00:03:15,630 +singular count nouns. That's the first group. And + +36 +00:03:15,630 --> 00:03:19,570 +the other group is used with what? Plural. So they + +37 +00:03:19,570 --> 00:03:23,710 +are used with count nouns in general. Some with + +38 +00:03:23,710 --> 00:03:26,890 +singular and other with plural. Can I use them + +39 +00:03:26,890 --> 00:03:30,790 +with non-count nouns? No, they cannot be used with + +40 +00:03:30,790 --> 00:03:35,090 +non-count nouns. This is the first group. Look at + +41 +00:03:35,090 --> 00:03:35,850 +the other group. + +42 +00:03:39,360 --> 00:03:43,720 +Much, a great deal of. Look at rice. What type of + +43 +00:03:43,720 --> 00:03:49,680 +noun is rice? Please speak. One speaker. Yeah. It + +44 +00:03:49,680 --> 00:03:52,860 +is an uncount noun. Thank you. It is an uncount. + +45 +00:03:53,400 --> 00:03:59,260 +So we say what? A little rice. Okay. We say much + +46 +00:03:59,260 --> 00:04:05,380 +and we say? A great deal of... So now we have + +47 +00:04:05,380 --> 00:04:09,120 +another three expressions. What are they? Yes, + +48 +00:04:09,440 --> 00:04:14,800 +Morida. A little, much, a great deal of... Yeah, + +49 +00:04:14,860 --> 00:04:18,300 +they are used with what type of nouns? Yes, who + +50 +00:04:18,300 --> 00:04:22,560 +was asking there? Any question? Who's asking? No + +51 +00:04:22,560 --> 00:04:27,480 +questions, okay. Now, this new group of + +52 +00:04:27,480 --> 00:04:31,200 +expressions is used with what? Non-count nouns. + +53 +00:04:31,660 --> 00:04:36,780 +Now look at these expressions. Now, no apples and + +54 +00:04:36,780 --> 00:04:41,760 +no rice. What does that mean? It is for count and + +55 +00:04:41,760 --> 00:04:44,920 +non-count. Thank you. They can be used with count, + +56 +00:04:45,140 --> 00:04:50,960 +with non-count nouns, okay? Now, hardly any can be + +57 +00:04:50,960 --> 00:04:54,660 +used. Yes, hardly any apples and hardly any what? + +58 +00:04:54,820 --> 00:04:57,620 +Rice. Yes, please read the other one. + +59 +00:05:04,590 --> 00:05:07,710 +Thank you. You know the difference between some + +60 +00:05:07,710 --> 00:05:13,690 +and any. Okay. Now I have some apples. I have some + +61 +00:05:13,690 --> 00:05:19,490 +money. I have some pens. Okay. But have you got + +62 +00:05:19,490 --> 00:05:25,910 +any money for example? Or I haven't got any food. + +63 +00:05:26,990 --> 00:05:33,410 +So some, yes Khadija? Positive, okay, yes thank + +64 +00:05:33,410 --> 00:05:38,490 +you. Affirmative, yeah? Questions and negative, + +65 +00:05:38,630 --> 00:05:43,050 +you are right, thank you, good. Now a lot of and + +66 +00:05:43,050 --> 00:05:48,910 +lots, a lot of and lots, they are used with, yes? + +67 +00:05:49,970 --> 00:05:53,730 +With count and non-count. You can say a lot of or + +68 +00:05:53,730 --> 00:05:57,990 +lots of what? Apples and lots of? Rice. Thank you. + +69 +00:05:58,350 --> 00:06:01,810 +Yes, please. Next one. Plenty of? Plenty of + +70 +00:06:01,810 --> 00:06:05,730 +apples, plenty of rice. Thank you. So this is also + +71 +00:06:05,730 --> 00:06:09,570 +used with what? Count and non-count nouns. And + +72 +00:06:09,570 --> 00:06:11,770 +what about most? Yes, Sahar? + +73 +00:06:14,590 --> 00:06:17,990 +Most rights. They are also, this is used also with + +74 +00:06:17,990 --> 00:06:21,910 +what? Count and non-count noun. What about the + +75 +00:06:21,910 --> 00:06:29,450 +other, the last one? All. Yes please. Yes. So this + +76 +00:06:29,450 --> 00:06:33,930 +is used again with what? With count and non-count + +77 +00:06:33,930 --> 00:06:37,790 +noun. So now we have three groups. The first group + +78 +00:06:37,790 --> 00:06:43,210 +is used with? Okay, what is the first group who + +79 +00:06:43,210 --> 00:06:48,970 +can read it again? Yes, please Okay, + +80 +00:06:49,070 --> 00:06:57,750 +this is singular count okay, thank you go on Okay, + +81 +00:06:57,790 --> 00:07:03,510 +they are used with Plural okay count. Thank you + +82 +00:07:03,510 --> 00:07:06,390 +and the other group. Yes Khadija a little much + +83 +00:07:07,120 --> 00:07:10,920 +They are + +84 +00:07:10,920 --> 00:07:14,900 +used only with non-count nouns. Thank you. And the + +85 +00:07:14,900 --> 00:07:16,340 +third group, Duaa. + +86 +00:07:21,940 --> 00:07:22,480 +Okay, + +87 +00:07:26,120 --> 00:07:28,740 +thank you. Can be used with count and with non + +88 +00:07:28,740 --> 00:07:31,800 +-count nouns. Now look at this exercise. Look at + +89 +00:07:31,800 --> 00:07:34,160 +your books. You have the exercise in the book. + +90 +00:07:34,540 --> 00:07:37,240 +Draw a line through the expressions that cannot be + +91 +00:07:37,240 --> 00:07:42,440 +used to complete the sentences. Draw a line. + +92 +00:07:45,680 --> 00:07:51,000 +Yes, please. Now, first of all, this is what? + +93 +00:07:51,800 --> 00:07:55,540 +Homework. Is it count or non-count noun? Non-count + +94 +00:07:55,540 --> 00:07:58,600 +noun. Okay. You have one minute. Do this one, + +95 +00:07:58,760 --> 00:08:02,220 +please. Do this one. One minute only. Go on. Go + +96 +00:08:02,220 --> 00:08:04,260 +on. Do it in your book, please. Do it in your + +97 +00:08:04,260 --> 00:08:04,560 +book. + +98 +00:08:07,620 --> 00:08:09,940 +If you have any question, raise your hand. + +99 +00:08:41,710 --> 00:08:45,790 +Yes. Tell me what shall, where shall we draw the + +100 +00:08:45,790 --> 00:08:49,150 +line? Where shall we draw the line? Yes, please. + +101 +00:08:49,430 --> 00:08:56,890 +Number three. Number one. Okay. + +102 +00:09:04,950 --> 00:09:09,430 +Yes, that cannot be used. Okay. So number one. + +103 +00:09:10,990 --> 00:09:16,370 +Okay. Number one. Good. Number six. Too many. + +104 +00:09:16,750 --> 00:09:22,030 +Okay. Number nine. Okay. Number nine. You are + +105 +00:09:22,030 --> 00:09:25,650 +right. Thank you. A number of. Good. Thank you. A + +106 +00:09:25,650 --> 00:09:28,670 +grade. What is a few? You are right. This is used + +107 +00:09:28,670 --> 00:09:34,630 +with count nouns. Thank you. What about two? + +108 +00:09:35,710 --> 00:09:38,810 +Several. With count nouns. Yes, used with count + +109 +00:09:38,810 --> 00:09:42,970 +nouns. You are right. Several homework. Okay. Now + +110 +00:09:42,970 --> 00:09:44,250 +what about the others? + +111 +00:09:47,150 --> 00:09:47,630 +Sorry? + +112 +00:09:50,170 --> 00:09:54,950 +Hardly any. Sorry, I can't get you. Hardly any? + +113 +00:09:55,070 --> 00:09:58,470 +Yes. Can be used. Which one? I know it can be used + +114 +00:09:58,470 --> 00:10:01,310 +for nine count, but I mean here. It can be used. + +115 +00:10:01,530 --> 00:10:03,550 +You said that any of them negative and positive, + +116 +00:10:03,770 --> 00:10:07,360 +right? No, no, no, hardly any. Even if it is + +117 +00:10:07,360 --> 00:10:12,960 +negative or positive, it can be used. Okay? Huda + +118 +00:10:12,960 --> 00:10:17,400 +has, okay, grammatically it is accepted. Yeah? + +119 +00:10:17,560 --> 00:10:23,340 +Huda has no homework. Accepted? Yeah, has no + +120 +00:10:23,340 --> 00:10:29,000 +homework. Can be used for plural count and for a + +121 +00:10:29,000 --> 00:10:33,440 +non-count. What about the others? What about the + +122 +00:10:33,440 --> 00:10:41,540 +others? Yes, please. Too much. Too much. Okay. + +123 +00:10:41,820 --> 00:10:47,660 +Should be deleted. Cannot be used. Good. Too much. + +124 +00:10:49,040 --> 00:10:55,760 +A little. Okay. What else? A great deal of. Okay. + +125 +00:10:55,820 --> 00:11:01,360 +A great deal of. Thank you. And some. Some. + +126 +00:11:09,430 --> 00:11:10,550 +Check your answers. + +127 +00:11:20,830 --> 00:11:24,740 +Now look at the other exercise. Complete The + +128 +00:11:24,740 --> 00:11:29,320 +sentences with much or many. Look, much or many. + +129 +00:11:29,500 --> 00:11:33,780 +What shall we use? Look, two words only. Also + +130 +00:11:33,780 --> 00:11:36,760 +write the plural form of the nouns as necessary. + +131 +00:11:37,420 --> 00:11:39,620 +In some sentences, you will need to choose the + +132 +00:11:39,620 --> 00:11:43,820 +correct verb. Sometimes we need to change the + +133 +00:11:43,820 --> 00:11:46,840 +verb. Number one. + +134 +00:11:49,700 --> 00:11:54,960 +Yes, number three here. I haven't. Go on. Much + +135 +00:11:54,960 --> 00:11:58,340 +mail lately. Much mail. Thank you. Good. + +136 +00:12:02,960 --> 00:12:09,260 +Number four. Go on. I don't get many letters. I + +137 +00:12:09,260 --> 00:12:14,300 +don't get many letters. Thank you. So I don't + +138 +00:12:14,300 --> 00:12:18,240 +get... Yes, + +139 +00:12:19,780 --> 00:12:24,380 +please. There is too much furniture. In Anna's + +140 +00:12:24,380 --> 00:12:28,820 +living room. There is too much. + +141 +00:12:31,820 --> 00:12:42,260 +Okay. There is too much. Good. Thank you. This is + +142 +00:12:42,260 --> 00:12:46,560 +what? This is number five. Okay. + +143 +00:12:49,190 --> 00:12:51,490 +Who's the speaker? Who's the speaker? What's on? + +144 +00:12:54,450 --> 00:12:55,270 +Delete what? + +145 +00:13:00,090 --> 00:13:09,010 +This one? Okay. There? Like that? There is too + +146 +00:13:09,010 --> 00:13:15,730 +much? Okay. Next one. Yes. + +147 +00:13:18,520 --> 00:13:26,200 +You want to ask? Answer, go on. Because it is + +148 +00:13:26,200 --> 00:13:30,120 +used. We used it here. It is used. You can delete + +149 +00:13:30,120 --> 00:13:35,000 +or you can keep. Did he ask us to delete it? No, + +150 +00:13:35,080 --> 00:13:39,640 +just use, okay? Use much or many? Since you write + +151 +00:13:39,640 --> 00:13:43,780 +it, this is the answer. And this expression is the + +152 +00:13:43,780 --> 00:13:47,020 +one which is considered, okay? So whether you + +153 +00:13:47,020 --> 00:13:52,910 +delete or you keep, There is two, okay. There is + +154 +00:13:52,910 --> 00:13:55,450 +two. You are right. It should be deleted because + +155 +00:13:55,450 --> 00:13:58,890 +it will be a repetition. Okay? It will be + +156 +00:13:58,890 --> 00:14:04,170 +repeated. Now, any question? I want to clean. No, + +157 +00:14:04,170 --> 00:14:04,730 +no. + +158 +00:14:10,810 --> 00:14:17,770 +Go on. This is yours. I can't. No, I can do it. I + +159 +00:14:17,770 --> 00:14:20,630 +can't go with you because I have too much work to + +160 +00:14:20,630 --> 00:14:27,390 +do. I can't go with you because I have too much. + +161 +00:14:27,730 --> 00:14:37,150 +Okay, thank you. Good. I have too much. Okay, yes, + +162 +00:14:37,210 --> 00:14:42,210 +please. Come, please, and write it. It is easier + +163 +00:14:42,210 --> 00:14:45,510 +for you to write. Come, please, and write it. + +164 +00:14:48,640 --> 00:14:57,560 +So this is number what? Number seven. How many + +165 +00:14:57,560 --> 00:14:59,940 +sides? Right sides. Okay. + +166 +00:15:04,100 --> 00:15:08,520 +Thank you. Next one. Yes, please. + +167 +00:15:15,060 --> 00:15:16,500 +Thank you. Good. + +168 +00:15:20,820 --> 00:15:26,260 +Okay. Next group, please. Come. I haven't met many + +169 +00:15:26,260 --> 00:15:30,720 +people since I came here. Come, please. Clean and + +170 +00:15:30,720 --> 00:15:40,120 +write. I haven't... + +171 +00:15:40,120 --> 00:15:42,620 +Okay, you cannot get it. Okay. Tell me, what shall + +172 +00:15:42,620 --> 00:15:47,580 +I write? Many. I haven't get... I haven't met... + +173 +00:15:47,580 --> 00:15:52,230 +Many people. Many people. Thank you. Yes, please. + +174 +00:16:02,010 --> 00:16:06,670 +How much? How much? Thank you. Number eleven. Yes, + +175 +00:16:06,750 --> 00:16:14,210 +please. I think there is too much violence. Yes, I + +176 +00:16:14,210 --> 00:16:17,210 +think there is too much violence. + +177 +00:16:22,580 --> 00:16:30,000 +Mm-hmm. Yes, please Could + +178 +00:16:30,000 --> 00:16:36,140 +you repeat it again, please you are right come + +179 +00:16:36,140 --> 00:16:44,620 +please come Next + +180 +00:16:44,620 --> 00:16:46,100 +one. Yes. Come please + +181 +00:17:02,080 --> 00:17:07,720 +Yes, come. The doctor, what did you write? Has so + +182 +00:17:07,720 --> 00:17:11,080 +many patients. You are right. Thank you. Next one. + +183 +00:17:17,380 --> 00:17:18,760 +How many teeth? + +184 +00:17:27,650 --> 00:17:31,590 +You are right, thank you. And finally, yes please. + +185 +00:17:33,210 --> 00:17:37,370 +You are right, come. + +186 +00:17:51,310 --> 00:17:52,150 +Thank you. + +187 +00:18:06,060 --> 00:18:10,080 +Now look at this exercise. If the given noun can + +188 +00:18:10,080 --> 00:18:14,060 +be used to complete the sentence, write it in its + +189 +00:18:14,060 --> 00:18:18,240 +correct form, singular or plural. If the given + +190 +00:18:18,240 --> 00:18:20,740 +noun cannot be used to complete the sentence, + +191 +00:18:20,960 --> 00:18:22,960 +write zero articles. + +192 +00:18:25,980 --> 00:18:29,700 +For example, + +223 +00:22:21,460 --> 00:22:22,820 +Number four. + +224 +00:22:38,820 --> 00:22:43,260 +Now listen. Now bread. Is it count or non-count + +225 +00:22:43,260 --> 00:22:48,960 +noun? It is non-count. Bread. Okay, it is month + +226 +00:22:48,960 --> 00:22:52,660 +count, but when we sell a loaf of bread, this is + +227 +00:22:52,660 --> 00:22:57,660 +count. So this is month count. And okay, also + +228 +00:22:57,660 --> 00:23:02,260 +honey. Thank you. Yes, please come. + +229 +00:23:31,470 --> 00:23:34,050 +Thank you. Good. Next one, come please. + +230 +00:23:43,310 --> 00:23:44,530 +Clean, then write. + +231 +00:23:55,070 --> 00:23:57,270 +Yes, read your answers. Talk while you are + +232 +00:23:57,270 --> 00:23:57,690 +writing. + +233 +00:24:00,860 --> 00:24:01,620 +Okay. + +234 +00:24:09,980 --> 00:24:14,620 +I bought some light bulbs. Bulbs. Okay, good. + +235 +00:24:22,400 --> 00:24:25,640 +I bought some hardware. Hardware, good. + +236 +00:24:32,880 --> 00:24:35,020 +And I bought some computer software. Software. + +237 +00:24:35,260 --> 00:24:37,200 +Thank you. Next one. Yes, please. Come. + +238 +00:25:02,840 --> 00:25:07,120 +Yes, plenty of is used with count and non-count. + +239 +00:25:08,000 --> 00:25:08,800 +Okay, sleep. + +240 +00:25:14,940 --> 00:25:22,540 +Good. Facts and help. Next one, come please. Thank + +241 +00:25:22,540 --> 00:25:22,800 +you. + +242 +00:25:29,520 --> 00:25:34,240 +Yes, both is used with Count. Gone. So. + +243 +00:25:39,920 --> 00:25:40,600 +Women. + +244 +00:25:50,320 --> 00:25:55,880 +Movies. Okay. Scenes. Zero article. Look, there is + +245 +00:25:55,880 --> 00:25:59,120 +a printing mistake here, right? This should be A. + +246 +00:26:00,350 --> 00:26:06,130 +Okay, next one. Next one. Yes, please. Come. Come. + +247 +00:26:07,250 --> 00:26:07,950 +Yes. + +248 +00:26:22,790 --> 00:26:24,470 +Read while writing. + +249 +00:26:31,940 --> 00:26:36,000 +Shirt. Shirt somewhere. Pens and chalk. Okay, + +250 +00:26:36,100 --> 00:26:37,900 +thank you. Yes, please. + +251 +00:26:44,580 --> 00:26:51,280 +Yeah. Okay. Number ten. Okay. This is number ten. + +252 +00:26:51,620 --> 00:26:59,300 +Clean and right. A great deal of used word. Okay, + +253 +00:26:59,440 --> 00:26:59,800 +go on. + +254 +00:27:12,540 --> 00:27:17,660 +Well, thank you. Yes, Eleven, come here please. + +255 +00:27:22,540 --> 00:27:26,980 +A little is used with? Non-count. Non-count, good. + +256 +00:27:41,130 --> 00:27:47,730 +Money. Advice, good. Time. + +257 +00:27:51,420 --> 00:27:54,080 +This cannot be used with minutes. You are right. + +258 +00:27:54,160 --> 00:27:58,760 +Thank you. Next one. Come, please. Okay, you next. + +259 +00:27:59,060 --> 00:28:04,040 +Yasmeen, after her. Get ready. Is it the last? + +260 +00:28:04,200 --> 00:28:07,840 +Okay. So, next exercise. + +261 +00:28:13,280 --> 00:28:20,580 +Many. With count nouns. So, we say many. Ideas, + +262 +00:28:20,640 --> 00:28:20,800 +yeah? + +263 +00:28:30,610 --> 00:28:36,110 +With E, there is, look at the, + +264 +00:28:39,190 --> 00:28:44,350 +there is no I, look at the spelling. Just change + +265 +00:28:44,350 --> 00:28:48,610 +the I into E. Clean it, clean it, all of it. + +266 +00:28:59,740 --> 00:29:01,940 +Thank you. And finally, knowledge. + +267 +00:29:05,700 --> 00:29:07,480 +Check your answers please. + +268 +00:29:30,500 --> 00:29:37,600 +Now, a few and a few are used with count nouns. A + +269 +00:29:37,600 --> 00:29:41,560 +little and little are used with non-count nouns. + +270 +00:29:41,700 --> 00:29:45,020 +What's the difference between few and a few? + +271 +00:29:45,950 --> 00:29:49,910 +Little and a little. Now we know that few and a + +272 +00:29:49,910 --> 00:29:53,610 +few used for count. Little and a little are used + +273 +00:29:53,610 --> 00:29:58,710 +for non-count. Now, as you see, we sang a few + +274 +00:29:58,710 --> 00:30:03,980 +songs. We listened to a little music. So a few and + +275 +00:30:03,980 --> 00:30:06,700 +a few are used with a plural count. A little and + +276 +00:30:06,700 --> 00:30:09,780 +little are used with non count. Now what's the + +277 +00:30:09,780 --> 00:30:12,720 +difference between a few and a few? Look at this + +278 +00:30:12,720 --> 00:30:15,900 +example. She has been here only for two weeks, but + +279 +00:30:15,900 --> 00:30:22,020 +she has already made what? A few friends. Okay. A + +280 +00:30:22,020 --> 00:30:28,120 +few friends. And she has made some friends. Read + +281 +00:30:28,120 --> 00:30:31,850 +the other example. Yes. I'm very pleased. I have + +282 +00:30:31,850 --> 00:30:35,010 +been able to save a little money this month. Okay, + +283 +00:30:35,150 --> 00:30:39,350 +good. Go on. A positive idea. I have saved some + +284 +00:30:39,350 --> 00:30:43,590 +money instead of spending all of it. A few and a + +285 +00:30:43,590 --> 00:30:47,530 +little give a positive idea. They indicate that + +286 +00:30:47,530 --> 00:30:50,530 +something excites it and represents it. Thank you. + +287 +00:30:50,590 --> 00:30:56,050 +Now listen. I have a little money. I can buy a + +288 +00:30:56,050 --> 00:30:59,930 +sandwich and I can take a taxi for my house. Okay? + +289 +00:31:00,750 --> 00:31:06,310 +I have little money. I cannot buy a sandwich and + +290 +00:31:06,310 --> 00:31:10,950 +just I can take a taxi. They will be enough for my + +291 +00:31:10,950 --> 00:31:16,760 +house, for the taxi to my house. Again, I have a + +292 +00:31:16,760 --> 00:31:20,480 +little, I can buy a sandwich and I can take a + +293 +00:31:20,480 --> 00:31:26,740 +taxi. I have little, I cannot do both of that. I + +294 +00:31:26,740 --> 00:31:31,320 +can only buy a sandwich or take a taxi. So, a + +295 +00:31:31,320 --> 00:31:34,500 +little is used to express what? Positive + +296 +00:31:34,500 --> 00:31:41,300 +situation, okay? And a few is also positive + +297 +00:31:41,300 --> 00:31:45,690 +situation. Considering that this is used with + +298 +00:31:45,690 --> 00:31:49,250 +count and this is used with non-count. Now if I + +299 +00:31:49,250 --> 00:31:55,410 +say, I have little petrol in my car. Can I go home + +300 +00:31:55,410 --> 00:31:59,490 +with this petrol? No, I'm afraid the car will stop + +301 +00:31:59,490 --> 00:32:02,090 +in the way, in the road, in the way to my house, + +302 +00:32:02,130 --> 00:32:06,810 +right? So, but if I have a few, if I have a + +303 +00:32:06,810 --> 00:32:10,570 +little, sorry, I can go to my house. It can take + +304 +00:32:10,570 --> 00:32:13,470 +me to my house. Can you give me some other + +305 +00:32:13,470 --> 00:32:19,430 +examples like that? Now listen, it is still + +306 +00:32:19,430 --> 00:32:24,200 +morning. And a few students only came to the + +307 +00:32:24,200 --> 00:32:32,560 +lecture. Can we start? No, we cannot start. A few + +308 +00:32:32,560 --> 00:32:36,790 +students came to the lecture. Can we start? A few + +309 +00:32:36,790 --> 00:32:41,630 +students, yes. Okay. A few students, we can start, + +310 +00:32:42,110 --> 00:32:46,730 +but few students, we cannot start. Okay. Give me + +311 +00:32:46,730 --> 00:32:50,210 +other examples. Yes, Yasmin. I have little sugar. + +312 +00:32:50,490 --> 00:32:54,530 +It's not enough to make tea. Okay. It is not + +313 +00:32:54,530 --> 00:32:58,210 +enough to make tea. Little sugar. I can't drink + +314 +00:32:58,210 --> 00:33:02,990 +this tea. It is not enough. Good. We have little + +315 +00:33:02,990 --> 00:33:07,500 +water. We cannot We cannot wash all the dishes. + +316 +00:33:07,660 --> 00:33:09,720 +Thank you very much. Good. A little water. + +317 +00:33:13,540 --> 00:33:17,320 +Now, look at this example, read please. I feel + +318 +00:33:17,320 --> 00:33:21,140 +sorry for her, she has very few friends. Okay, she + +319 +00:33:21,140 --> 00:33:25,320 +has very few friends. Look at this sentence. She + +320 +00:33:25,320 --> 00:33:30,420 +has been here only two weeks, but she has already + +321 +00:33:30,420 --> 00:33:34,680 +made what? A few friends. Okay, this is good. She + +322 +00:33:34,680 --> 00:33:38,180 +has some friends, okay? She has some friends, but + +323 +00:33:38,180 --> 00:33:43,200 +now this one, I feel sorry. Most of the time she + +324 +00:33:43,200 --> 00:33:47,740 +is alone. She has only few friends. Expresses + +325 +00:33:47,740 --> 00:33:52,180 +what? Negative. Expresses a negative situation. + +326 +00:33:52,680 --> 00:33:55,940 +Okay, the other one. Yes, please. I have very + +327 +00:33:55,940 --> 00:33:58,400 +little money. I don't even have enough money to + +328 +00:33:58,400 --> 00:34:01,240 +buy food for dinner. That's right. I have a + +329 +00:34:01,240 --> 00:34:05,720 +little, I can buy. I have a little, I can buy. I + +330 +00:34:05,720 --> 00:34:06,320 +have little, + +331 +00:34:09,590 --> 00:34:15,570 +I can't buy. Now, few and little without a give a + +332 +00:34:15,570 --> 00:34:17,730 +negative idea, negative situation. + +333 +00:34:19,980 --> 00:34:23,440 +They indicate that something is largely absent. + +334 +00:34:24,040 --> 00:34:28,640 +Largely absent. I say there are only few students. + +335 +00:34:28,760 --> 00:34:32,340 +I cannot start the lecture. Okay? Because a great + +336 +00:34:32,340 --> 00:34:36,660 +number of students are absent. Now, when I say + +337 +00:34:36,660 --> 00:34:40,880 +very few and very little, this makes the negative + +338 +00:34:40,880 --> 00:34:46,800 +stronger. Emphasizes the meaning. Yeah. Emphasizes + +339 +00:34:46,800 --> 00:34:51,880 +the amount or the number or whatsoever. Okay. Now + +340 +00:34:51,880 --> 00:34:55,500 +again, who can tell us what's the main difference + +341 +00:34:55,500 --> 00:34:59,260 +between a few and a few, little and a little? Yes, + +342 +00:34:59,360 --> 00:34:59,620 +please. + +343 +00:35:21,310 --> 00:35:24,190 +Thank you very much. Now look at this exercise in + +344 +00:35:24,190 --> 00:35:28,010 +your book. Okay? Without changing the meaning of + +345 +00:35:28,010 --> 00:35:30,590 +the sentence. This is very important. Don't change + +346 +00:35:30,590 --> 00:35:35,410 +the meaning. Replace the Italy-sized words with a + +347 +00:35:35,410 --> 00:35:39,770 +few, very few, a little, or very little. Okay? + +348 +00:35:40,190 --> 00:35:43,530 +Now, these words are the Italy-sized ones. They + +349 +00:35:43,530 --> 00:35:48,430 +are written here in blue. Yes, your book, they are + +350 +00:35:48,430 --> 00:35:52,250 +Italy-sized. You know Italy-sized? Yes. Okay. + +351 +00:35:57,450 --> 00:36:04,590 +Number one. Read it, Yasmin. Okay, a little + +352 +00:36:04,590 --> 00:36:08,390 +sunshine + +353 +00:36:08,390 --> 00:36:10,730 +is better than none. Do you agree with the answer? + +354 +00:36:11,210 --> 00:36:15,470 +Okay, good. Next one. Do number four and five. Do + +355 +00:36:15,470 --> 00:36:16,650 +number four and five. + +356 +00:36:35,690 --> 00:36:41,490 +Okay, number four, Suha. January is a cold and + +357 +00:36:41,490 --> 00:36:45,090 +dreary month in the northern states. There is + +358 +00:36:45,090 --> 00:36:51,370 +little sunshine during that month. There is little + +359 +00:36:51,370 --> 00:36:55,830 +sunshine. Or there is very little. Okay. Or there + +360 +00:36:55,830 --> 00:36:58,590 +is very little. Good. Thank you very much. Next + +361 +00:36:58,590 --> 00:37:03,750 +one. Yes, please. My parents like to watch TV + +362 +00:37:03,750 --> 00:37:07,630 +every evening. They watch a few programs on TV + +363 +00:37:07,630 --> 00:37:10,950 +before they go to bed. Thank you. They watch a + +364 +00:37:10,950 --> 00:37:18,110 +few. Good. Now, do number six, seven, eight, and + +365 +00:37:18,110 --> 00:37:18,470 +nine. + +366 +00:37:21,880 --> 00:37:22,300 +Good luck. + +367 +00:37:25,700 --> 00:37:26,360 +Watch out. + +368 +00:38:02,340 --> 00:38:05,340 +Okay, number six. Yes, please. + +369 +00:38:08,720 --> 00:38:11,980 +There are + +370 +00:38:11,980 --> 00:38:16,240 +few television programs. Thank you. Number seven. + +371 +00:38:16,900 --> 00:38:17,500 +Yes, please. + +372 +00:38:24,780 --> 00:38:31,400 +Okay, thank you. Good. Next one. Yes, please. If + +373 +00:38:31,400 --> 00:38:35,840 +your door squeaks, put a little oil on the hinges. + +374 +00:38:37,460 --> 00:38:38,060 +Okay, + +375 +00:38:40,920 --> 00:38:47,400 +thank you. Good. Yeah, number six. What about + +376 +00:38:47,400 --> 00:38:52,780 +number six? Yeah, what did she say? Repeat your + +377 +00:38:52,780 --> 00:38:59,220 +answer. You did number eight. Okay, repeat it + +378 +00:38:59,220 --> 00:38:59,960 +again, please. + +379 +00:39:02,890 --> 00:39:07,610 +Okay, thank you. And number seven. + +380 +00:39:10,970 --> 00:39:19,850 +Okay, a few drops. Thank you. Sorry? Now, she did + +381 +00:39:19,850 --> 00:39:24,010 +it. She did it. Number nine. Finally, number nine. + +382 +00:39:25,820 --> 00:39:28,760 +Mr. Adams doesn't like to wear prints on his + +383 +00:39:28,760 --> 00:39:32,900 +fingers. He wears very little shoes. Thank you. + +384 +00:39:33,120 --> 00:39:35,060 +Check the answers. You have the answers. + +385 +00:39:50,540 --> 00:39:53,700 +Okay, this exercise, do at home, please. + +386 +00:39:56,500 --> 00:40:02,000 +This exercise at home. Thank you very much. diff --git a/PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/F1TSPatwy-0_raw.json b/PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/F1TSPatwy-0_raw.json new file mode 100644 index 0000000000000000000000000000000000000000..9015fde8bd0c2b8331c2360b327831496468a587 --- /dev/null +++ b/PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/F1TSPatwy-0_raw.json @@ -0,0 +1 @@ +{"segments": [{"id": 1, "seek": 4180, "start": 21.1, "end": 41.8, "text": " Assalamualaikum. Good morning to you all. How are you? What did you do yesterday Khadija? I studied for Quran exam. Okay, good. She studied for the exam. She studied for the exam. 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Tell me about that. Use one of these expressions to express the situation. You help your mother and your mother helps you. Yeah, we help each other. Thank you very much. We help each other or we help one another. Okay, we help each other or we help one another.", "tokens": [400, 291, 11, 558, 30, 5115, 385, 466, 300, 13, 8278, 472, 295, 613, 15277, 281, 5109, 264, 2590, 13, 509, 854, 428, 2895, 293, 428, 2895, 3665, 291, 13, 865, 11, 321, 854, 1184, 661, 13, 1044, 291, 588, 709, 13, 492, 854, 1184, 661, 420, 321, 854, 472, 1071, 13, 1033, 11, 321, 854, 1184, 661, 420, 321, 854, 472, 1071, 13], "avg_logprob": -0.1763221153846154, "compression_ratio": 1.8051948051948052, "no_speech_prob": 0.0, "words": [{"start": 119.36, "end": 119.74, "word": " And", "probability": 0.54833984375}, {"start": 119.74, "end": 120.0, "word": " you,", "probability": 0.8759765625}, {"start": 120.3, "end": 120.44, "word": " right?", "probability": 0.82568359375}, {"start": 120.72, "end": 120.9, "word": " Tell", "probability": 0.85107421875}, {"start": 120.9, "end": 121.1, "word": " me", "probability": 0.9580078125}, {"start": 121.1, "end": 121.42, "word": " about", "probability": 0.8837890625}, {"start": 121.42, "end": 121.72, "word": " that.", "probability": 0.85693359375}, {"start": 121.82, "end": 122.02, "word": " Use", "probability": 0.9052734375}, {"start": 122.02, "end": 122.28, "word": " one", "probability": 0.88134765625}, {"start": 122.28, "end": 122.44, "word": " of", "probability": 0.96826171875}, {"start": 122.44, "end": 122.64, "word": " these", "probability": 0.8369140625}, {"start": 122.64, "end": 123.2, "word": " expressions", "probability": 0.89697265625}, {"start": 123.2, "end": 123.5, "word": " to", "probability": 0.95361328125}, {"start": 123.5, "end": 123.86, "word": " express", "probability": 0.748046875}, {"start": 123.86, "end": 124.12, "word": " the", "probability": 0.88671875}, {"start": 124.12, "end": 124.7, "word": " situation.", "probability": 0.92626953125}, {"start": 127.14, "end": 127.74, "word": " You", "probability": 0.62939453125}, {"start": 127.74, "end": 128.12, "word": " help", "probability": 0.88330078125}, {"start": 128.12, "end": 128.4, "word": " your", "probability": 0.8828125}, {"start": 128.4, "end": 128.78, "word": " mother", "probability": 0.837890625}, {"start": 128.78, "end": 129.24, "word": " and", "probability": 0.626953125}, {"start": 129.24, "end": 129.42, "word": " your", "probability": 0.830078125}, {"start": 129.42, "end": 129.78, "word": " mother", "probability": 0.849609375}, {"start": 129.78, "end": 130.2, "word": " helps", "probability": 0.83056640625}, {"start": 130.2, "end": 130.5, "word": " you.", "probability": 0.958984375}, {"start": 131.22, "end": 131.22, "word": " Yeah,", "probability": 0.1474609375}, {"start": 131.6, "end": 131.82, "word": " we", "probability": 0.84814453125}, {"start": 131.82, "end": 135.96, "word": " help", "probability": 0.89697265625}, {"start": 135.96, "end": 136.22, "word": " each", "probability": 0.9423828125}, {"start": 136.22, "end": 136.5, "word": " other.", "probability": 0.89208984375}, {"start": 136.58, "end": 136.78, "word": " Thank", "probability": 0.87353515625}, {"start": 136.78, "end": 136.92, "word": " you", "probability": 0.96337890625}, {"start": 136.92, "end": 137.1, "word": " very", "probability": 0.8447265625}, {"start": 137.1, "end": 137.4, "word": " much.", "probability": 0.90673828125}, {"start": 137.8, "end": 137.94, "word": " We", "probability": 0.92724609375}, {"start": 137.94, "end": 138.36, "word": " help", "probability": 0.8974609375}, {"start": 138.36, "end": 138.76, "word": " each", "probability": 0.9326171875}, {"start": 138.76, "end": 139.08, "word": " other", "probability": 0.89208984375}, {"start": 139.08, "end": 139.62, "word": " or", "probability": 0.56884765625}, {"start": 139.62, "end": 139.86, "word": " we", "probability": 0.92822265625}, {"start": 139.86, "end": 140.26, "word": " help", "probability": 0.9033203125}, {"start": 140.26, "end": 140.6, "word": " one", "probability": 0.90087890625}, {"start": 140.6, "end": 141.06, "word": " another.", "probability": 0.923828125}, {"start": 141.64, "end": 141.94, "word": " Okay,", "probability": 0.75634765625}, {"start": 142.16, "end": 142.36, "word": " we", "probability": 0.94189453125}, {"start": 142.36, "end": 142.7, "word": " help", "probability": 0.90478515625}, {"start": 142.7, "end": 143.0, "word": " each", "probability": 0.93701171875}, {"start": 143.0, "end": 143.34, "word": " other", "probability": 0.88916015625}, {"start": 143.34, "end": 143.62, "word": " or", "probability": 0.91650390625}, {"start": 143.62, "end": 143.82, "word": " we", "probability": 0.95654296875}, {"start": 143.82, "end": 144.2, "word": " help", "probability": 0.904296875}, {"start": 144.2, "end": 144.68, "word": " one", "probability": 0.92431640625}, {"start": 144.68, "end": 145.38, "word": " another.", "probability": 0.92431640625}], "temperature": 1.0}, {"id": 6, "seek": 16701, "start": 145.95, "end": 167.01, "text": " Now, these are two expressions, almost they have what? The same meaning. Almost they have the same meaning. But, read this note please. Yeah. Interchangeable. You can change this with that and that with this. Okay.", "tokens": [823, 11, 613, 366, 732, 15277, 11, 1920, 436, 362, 437, 30, 440, 912, 3620, 13, 12627, 436, 362, 264, 912, 3620, 13, 583, 11, 1401, 341, 3637, 1767, 13, 865, 13, 5751, 15431, 712, 13, 509, 393, 1319, 341, 365, 300, 293, 300, 365, 341, 13, 1033, 13], "avg_logprob": -0.2551562488079071, "compression_ratio": 1.5357142857142858, "no_speech_prob": 0.0, "words": [{"start": 145.95, "end": 146.31, "word": " Now,", "probability": 0.84375}, {"start": 146.99, "end": 147.43, "word": " these", "probability": 0.85498046875}, {"start": 147.43, "end": 147.87, "word": " are", "probability": 0.916015625}, {"start": 147.87, "end": 148.45, "word": " two", "probability": 0.89892578125}, {"start": 148.45, "end": 149.15, "word": " expressions,", "probability": 0.91796875}, {"start": 149.81, "end": 150.31, "word": " almost", "probability": 0.5947265625}, {"start": 150.31, "end": 150.59, "word": " they", "probability": 0.833984375}, {"start": 150.59, "end": 150.99, "word": " have", "probability": 0.947265625}, {"start": 150.99, "end": 151.29, "word": " what?", "probability": 0.470703125}, {"start": 151.71, "end": 151.99, "word": " The", "probability": 0.7763671875}, {"start": 151.99, "end": 152.55, "word": " same", "probability": 0.90576171875}, {"start": 152.55, "end": 153.37, "word": " meaning.", "probability": 0.8603515625}, {"start": 153.87, "end": 154.21, "word": " Almost", "probability": 0.57275390625}, {"start": 154.21, "end": 154.55, "word": " they", "probability": 0.8193359375}, {"start": 154.55, "end": 154.87, "word": " have", "probability": 0.94970703125}, {"start": 154.87, "end": 155.05, "word": " the", "probability": 0.91552734375}, {"start": 155.05, "end": 155.31, "word": " same", "probability": 0.9033203125}, {"start": 155.31, "end": 155.65, "word": " meaning.", "probability": 0.857421875}, {"start": 155.99, "end": 156.33, "word": " But,", "probability": 0.943359375}, {"start": 156.65, "end": 156.89, "word": " read", "probability": 0.94677734375}, {"start": 156.89, "end": 157.13, "word": " this", "probability": 0.93603515625}, {"start": 157.13, "end": 157.43, "word": " note", "probability": 0.8828125}, {"start": 157.43, "end": 157.89, "word": " please.", "probability": 0.63720703125}, {"start": 158.19, "end": 158.19, "word": " Yeah.", "probability": 0.5166015625}, {"start": 163.37, "end": 164.05, "word": " Interchangeable.", "probability": 0.7730305989583334}, {"start": 164.15, "end": 164.29, "word": " You", "probability": 0.91650390625}, {"start": 164.29, "end": 164.57, "word": " can", "probability": 0.94580078125}, {"start": 164.57, "end": 164.95, "word": " change", "probability": 0.8740234375}, {"start": 164.95, "end": 165.23, "word": " this", "probability": 0.94384765625}, {"start": 165.23, "end": 165.47, "word": " with", "probability": 0.89501953125}, {"start": 165.47, "end": 165.83, "word": " that", "probability": 0.93505859375}, {"start": 165.83, "end": 166.09, "word": " and", "probability": 0.69873046875}, {"start": 166.09, "end": 166.35, "word": " that", "probability": 0.91455078125}, {"start": 166.35, "end": 166.57, "word": " with", "probability": 0.90283203125}, {"start": 166.57, "end": 166.77, "word": " this.", "probability": 0.92138671875}, {"start": 166.77, "end": 167.01, "word": " Okay.", "probability": 0.7314453125}], "temperature": 1.0}, {"id": 7, "seek": 18646, "start": 167.4, "end": 186.46, "text": " There is no difference between them. Some native speakers however use each other when they are talking about only one person or thing, and one another when they are more than two. Okay, thank you. This happens in everyday language. 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For example, people should help one another. It means the society, all the people. But if they are talking about two people, they say what? Each other. Good. 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Now, how often do you visit your grandmom? How often do you visit your grandmom? Yes? Every week. You have time to visit her every week? Okay, thank you. 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This week, yes. The other week, no. And so on, okay? Every this week. Now, again, how often do you go shopping? How often does your father go shopping or you go shopping? 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Every other month. It means one month yes and one month no. Okay, good. How often do you make cakes, Morida? 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Every other month. Okay. Now, when she says every other month, it means how many cakes does she make in a year? Six. Six. Very good. Thank you. That's right. Okay. Now, today is what? Wednesday. Wednesday. Yesterday was? Tuesday. Tuesday. 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Thank you very much. Good. Now, look at this sentence. You have a nice picture in your book if you look at the book. Okay? Now, how do you leave this class? You are sitting together. 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One after the other. It means what? Okay, there is time. Good, thank you very much. Even it is a very short time. Go on, please. One after the other expresses the idea that separate action occurred very close in time. Thank you very much. Now, some students were late when we started, right? 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A group of students came one after the other. Or we can say also one after what? One after another. Okay. Now, there is a secret. 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Okay, now in other words, I can explain that nobody knows rather than Fatima. Okay? Nobody knows rather than Fatima. Now I used what? Nobody knows rather than. Rather than. 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So, no one can speak French other than Fatima. Other than Fatima. We said nobody. We used the negative. And after the negative, we used what other than to mean what? To mean except. Okay? To mean except. 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Other than my father. Who does the cooking? Who cooks your food? Give me a good sentence. Yes, please. No one cooks other than mom. Very good. No one cooks other than mom. Okay. 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Thank you very much. So now in other words, they explain what they are good for you. This is an explanation for what was mentioned before. Now we want to answer the questions. Exercise one. Complete the sentences with what? A form of other. Number one. Yes, please. 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Thank you. Of course, Saudi is too confused. There are many other places I would like to see. Thank you very much. Good. Next one. 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Okay, good, thank you. Okay, thank you. 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I'd like to go with you, but I have already made other plans. Other plans. Thank you. Good. Yes, please. Clean, clean, clean, then write.", "tokens": [1044, 291, 337, 18202, 385, 281, 264, 32137, 13, 286, 1116, 411, 281, 352, 365, 291, 11, 457, 286, 362, 1217, 1027, 661, 5482, 13, 5358, 5482, 13, 1044, 291, 13, 2205, 13, 1079, 11, 1767, 13, 18463, 11, 2541, 11, 2541, 11, 550, 2464, 13], "avg_logprob": -0.25598403621227184, "compression_ratio": 1.366412213740458, "no_speech_prob": 0.0, "words": [{"start": 765.92, "end": 766.24, "word": " Thank", "probability": 0.3359375}, {"start": 766.24, "end": 766.38, "word": " you", "probability": 0.9599609375}, {"start": 766.38, "end": 766.58, "word": " for", "probability": 0.943359375}, {"start": 766.58, "end": 766.9, "word": " inviting", "probability": 0.4736328125}, {"start": 766.9, "end": 767.22, "word": " me", "probability": 0.95361328125}, {"start": 767.22, "end": 767.44, "word": " to", "probability": 0.86083984375}, {"start": 767.44, "end": 767.56, "word": " the", "probability": 0.87109375}, {"start": 767.56, "end": 767.78, "word": " picnic.", "probability": 0.986328125}, {"start": 768.2, "end": 768.44, "word": " I'd", "probability": 0.837646484375}, {"start": 768.44, "end": 768.6, "word": " like", "probability": 0.92626953125}, {"start": 768.6, "end": 768.78, "word": " to", "probability": 0.970703125}, {"start": 768.78, "end": 768.94, "word": " go", "probability": 0.95947265625}, {"start": 768.94, "end": 769.14, "word": " with", "probability": 0.52880859375}, {"start": 769.14, "end": 769.34, "word": " you,", "probability": 0.9560546875}, {"start": 769.68, "end": 769.88, "word": " but", "probability": 0.92041015625}, {"start": 769.88, "end": 770.22, "word": " I", "probability": 0.99365234375}, {"start": 770.22, "end": 770.46, "word": " have", "probability": 0.81494140625}, {"start": 770.46, "end": 770.92, "word": " already", "probability": 0.9208984375}, {"start": 770.92, "end": 771.38, "word": " made", "probability": 0.90185546875}, {"start": 771.38, "end": 771.82, "word": " other", "probability": 0.8310546875}, {"start": 771.82, "end": 772.28, "word": " plans.", "probability": 0.93408203125}, {"start": 772.52, "end": 772.74, "word": " Other", "probability": 0.7919921875}, {"start": 772.74, "end": 773.16, "word": " plans.", "probability": 0.93896484375}, {"start": 773.26, "end": 773.46, "word": " Thank", "probability": 0.8681640625}, {"start": 773.46, "end": 773.76, "word": " you.", "probability": 0.9609375}, {"start": 774.06, "end": 774.3, "word": " Good.", "probability": 0.84619140625}, {"start": 774.86, "end": 775.08, "word": " Yes,", "probability": 0.9677734375}, {"start": 775.16, "end": 775.46, "word": " please.", "probability": 0.8193359375}, {"start": 781.58, "end": 782.14, "word": " Clean,", "probability": 0.59619140625}, {"start": 782.68, "end": 783.16, "word": " clean,", "probability": 0.853515625}, {"start": 783.26, "end": 783.56, "word": " clean,", "probability": 0.8154296875}, {"start": 784.12, "end": 784.38, "word": " then", "probability": 0.81298828125}, {"start": 784.38, "end": 784.76, "word": " write.", "probability": 0.7939453125}], "temperature": 1.0}, {"id": 31, "seek": 82040, "start": 804.46, "end": 820.4, "text": " Okay, good. Other people, not others, good. Okay, thank you. Yes please.", "tokens": [1033, 11, 665, 13, 5358, 561, 11, 406, 2357, 11, 665, 13, 1033, 11, 1309, 291, 13, 1079, 1767, 13], "avg_logprob": -0.27901785714285715, "compression_ratio": 1.0895522388059702, "no_speech_prob": 0.0, "words": [{"start": 804.46, "end": 805.12, "word": " Okay,", "probability": 0.1776123046875}, {"start": 805.26, "end": 805.5, "word": " good.", "probability": 0.86865234375}, {"start": 814.48, "end": 815.14, "word": " Other", "probability": 0.81005859375}, {"start": 815.14, "end": 816.36, "word": " people,", "probability": 0.94775390625}, {"start": 816.52, "end": 816.7, "word": " not", "probability": 0.9384765625}, {"start": 816.7, "end": 817.06, "word": " others,", "probability": 0.892578125}, {"start": 817.2, "end": 817.38, "word": " good.", "probability": 0.91650390625}, {"start": 817.74, "end": 818.32, "word": " Okay,", "probability": 0.79248046875}, {"start": 818.54, "end": 818.74, "word": " thank", "probability": 0.8525390625}, {"start": 818.74, "end": 818.98, "word": " you.", "probability": 0.96435546875}, {"start": 819.48, "end": 820.1, "word": " Yes", "probability": 0.9453125}, {"start": 820.1, "end": 820.4, "word": " please.", "probability": 0.3095703125}], "temperature": 1.0}, {"id": 32, "seek": 84911, "start": 836.03, "end": 849.11, "text": " They support each other. They like each other.", "tokens": [814, 1406, 1184, 661, 13, 814, 411, 1184, 661, 13], "avg_logprob": -0.4524147781458768, "compression_ratio": 1.119047619047619, "no_speech_prob": 0.0, "words": [{"start": 836.0300000000001, "end": 837.4300000000001, "word": " They", "probability": 0.0780029296875}, {"start": 837.4300000000001, "end": 838.83, "word": " support", "probability": 0.60693359375}, {"start": 838.83, "end": 839.57, "word": " each", "probability": 0.80224609375}, {"start": 839.57, "end": 839.97, "word": " other.", "probability": 0.853515625}, {"start": 845.83, "end": 847.23, "word": " They", "probability": 0.73974609375}, {"start": 847.23, "end": 847.81, "word": " like", "probability": 0.9130859375}, {"start": 847.81, "end": 848.61, "word": " each", "probability": 0.92529296875}, {"start": 848.61, "end": 849.11, "word": " other.", "probability": 0.89697265625}], "temperature": 1.0}, {"id": 33, "seek": 87914, "start": 852.56, "end": 879.14, "text": " Sorry? Okay, okay, good, good. Each other, each other, it's okay. Don't clean by hand, okay? Each other, okay? In other words, in other words. Thank you. Yes, please. How often do you travel to Portland?", "tokens": [4919, 30, 1033, 11, 1392, 11, 665, 11, 665, 13, 6947, 661, 11, 1184, 661, 11, 309, 311, 1392, 13, 1468, 380, 2541, 538, 1011, 11, 1392, 30, 6947, 661, 11, 1392, 30, 682, 661, 2283, 11, 294, 661, 2283, 13, 1044, 291, 13, 1079, 11, 1767, 13, 1012, 2049, 360, 291, 3147, 281, 25020, 30], "avg_logprob": -0.2276589975022433, "compression_ratio": 1.489051094890511, "no_speech_prob": 0.0, "words": [{"start": 852.56, "end": 853.14, "word": " Sorry?", "probability": 0.378173828125}, {"start": 853.14, "end": 853.72, "word": " Okay,", "probability": 0.6259765625}, {"start": 853.96, "end": 854.26, "word": " okay,", "probability": 0.84033203125}, {"start": 854.3, "end": 854.56, "word": " good,", "probability": 0.912109375}, {"start": 854.64, "end": 854.88, "word": " good.", "probability": 0.923828125}, {"start": 855.54, "end": 856.12, "word": " Each", "probability": 0.286865234375}, {"start": 856.12, "end": 856.42, "word": " other,", "probability": 0.89794921875}, {"start": 856.54, "end": 856.76, "word": " each", "probability": 0.916015625}, {"start": 856.76, "end": 857.0, "word": " other,", "probability": 0.88818359375}, {"start": 857.12, "end": 857.2, "word": " it's", "probability": 0.957763671875}, {"start": 857.2, "end": 857.48, "word": " okay.", "probability": 0.90869140625}, {"start": 857.66, "end": 857.88, "word": " Don't", "probability": 0.903564453125}, {"start": 857.88, "end": 858.2, "word": " clean", "probability": 0.45703125}, {"start": 858.2, "end": 858.44, "word": " by", "probability": 0.96435546875}, {"start": 858.44, "end": 858.9, "word": " hand,", "probability": 0.91357421875}, {"start": 859.02, "end": 859.28, "word": " okay?", "probability": 0.89501953125}, {"start": 859.46, "end": 859.8, "word": " Each", "probability": 0.93408203125}, {"start": 859.8, "end": 861.62, "word": " other,", "probability": 0.499755859375}, {"start": 862.82, "end": 863.44, "word": " okay?", "probability": 0.87890625}, {"start": 864.4, "end": 864.98, "word": " In", "probability": 0.6923828125}, {"start": 864.98, "end": 865.38, "word": " other", "probability": 0.90283203125}, {"start": 865.38, "end": 867.1, "word": " words,", "probability": 0.85986328125}, {"start": 867.64, "end": 867.84, "word": " in", "probability": 0.83740234375}, {"start": 867.84, "end": 868.5, "word": " other", "probability": 0.8974609375}, {"start": 868.5, "end": 868.88, "word": " words.", "probability": 0.8662109375}, {"start": 868.98, "end": 869.18, "word": " Thank", "probability": 0.7490234375}, {"start": 869.18, "end": 869.42, "word": " you.", "probability": 0.96044921875}, {"start": 870.5, "end": 870.76, "word": " Yes,", "probability": 0.96728515625}, {"start": 870.86, "end": 871.18, "word": " please.", "probability": 0.80078125}, {"start": 876.96, "end": 877.54, "word": " How", "probability": 0.79931640625}, {"start": 877.54, "end": 877.94, "word": " often", "probability": 0.81103515625}, {"start": 877.94, "end": 878.1, "word": " do", "probability": 0.953125}, {"start": 878.1, "end": 878.2, "word": " you", "probability": 0.96630859375}, {"start": 878.2, "end": 878.5, "word": " travel", "probability": 0.8759765625}, {"start": 878.5, "end": 878.76, "word": " to", "probability": 0.97412109375}, {"start": 878.76, "end": 879.14, "word": " Portland?", "probability": 0.9716796875}], "temperature": 1.0}, {"id": 34, "seek": 89766, "start": 879.98, "end": 897.66, "text": " Every other month I go there to visit my grandmother in nursing home. Thank you. Yes please, come. Every other month. Number ten.", "tokens": [2048, 661, 1618, 286, 352, 456, 281, 3441, 452, 14317, 294, 15423, 1280, 13, 1044, 291, 13, 1079, 1767, 11, 808, 13, 2048, 661, 1618, 13, 5118, 2064, 13], "avg_logprob": -0.28098959227403003, "compression_ratio": 1.2871287128712872, "no_speech_prob": 0.0, "words": [{"start": 879.98, "end": 880.32, "word": " Every", "probability": 0.70458984375}, {"start": 880.32, "end": 880.64, "word": " other", "probability": 0.865234375}, {"start": 880.64, "end": 881.04, "word": " month", "probability": 0.90234375}, {"start": 881.04, "end": 881.28, "word": " I", "probability": 0.72802734375}, {"start": 881.28, "end": 881.5, "word": " go", "probability": 0.88525390625}, {"start": 881.5, "end": 881.74, "word": " there", "probability": 0.60791015625}, {"start": 881.74, "end": 881.94, "word": " to", "probability": 0.7744140625}, {"start": 881.94, "end": 882.16, "word": " visit", "probability": 0.9697265625}, {"start": 882.16, "end": 882.46, "word": " my", "probability": 0.9580078125}, {"start": 882.46, "end": 882.86, "word": " grandmother", "probability": 0.80029296875}, {"start": 882.86, "end": 883.4, "word": " in", "probability": 0.435791015625}, {"start": 883.4, "end": 884.28, "word": " nursing", "probability": 0.52197265625}, {"start": 884.28, "end": 884.68, "word": " home.", "probability": 0.83935546875}, {"start": 884.72, "end": 885.04, "word": " Thank", "probability": 0.6611328125}, {"start": 885.04, "end": 885.36, "word": " you.", "probability": 0.94921875}, {"start": 886.18, "end": 886.66, "word": " Yes", "probability": 0.95263671875}, {"start": 886.66, "end": 887.06, "word": " please,", "probability": 0.432373046875}, {"start": 887.42, "end": 887.68, "word": " come.", "probability": 0.865234375}, {"start": 889.24, "end": 889.66, "word": " Every", "probability": 0.8701171875}, {"start": 889.66, "end": 890.0, "word": " other", "probability": 0.89453125}, {"start": 890.0, "end": 890.44, "word": " month.", "probability": 0.91943359375}, {"start": 896.58, "end": 897.3, "word": " Number", "probability": 0.83251953125}, {"start": 897.3, "end": 897.66, "word": " ten.", "probability": 0.51171875}], "temperature": 1.0}, {"id": 35, "seek": 93153, "start": 907.43, "end": 931.53, "text": " Thank you very much. Good. Yes, please. Another. Okay. One cookie after another.", "tokens": [1044, 291, 588, 709, 13, 2205, 13, 1079, 11, 1767, 13, 3996, 13, 1033, 13, 1485, 14417, 934, 1071, 13], "avg_logprob": -0.3188243934086391, "compression_ratio": 1.0, "no_speech_prob": 0.0, "words": [{"start": 907.4299999999998, "end": 908.3699999999999, "word": " Thank", "probability": 0.062164306640625}, {"start": 908.3699999999999, "end": 909.31, "word": " you", "probability": 0.9541015625}, {"start": 909.31, "end": 909.51, "word": " very", "probability": 0.84033203125}, {"start": 909.51, "end": 909.81, "word": " much.", "probability": 0.91796875}, {"start": 909.91, "end": 910.09, "word": " Good.", "probability": 0.82177734375}, {"start": 911.15, "end": 911.35, "word": " Yes,", "probability": 0.9296875}, {"start": 911.47, "end": 911.79, "word": " please.", "probability": 0.81982421875}, {"start": 926.55, "end": 927.49, "word": " Another.", "probability": 0.63427734375}, {"start": 928.35, "end": 928.69, "word": " Okay.", "probability": 0.76953125}, {"start": 929.35, "end": 929.89, "word": " One", "probability": 0.91650390625}, {"start": 929.89, "end": 930.59, "word": " cookie", "probability": 0.92236328125}, {"start": 930.59, "end": 931.11, "word": " after", "probability": 0.83251953125}, {"start": 931.11, "end": 931.53, "word": " another.", "probability": 0.91650390625}], "temperature": 1.0}, {"id": 36, "seek": 96141, "start": 933.11, "end": 961.41, "text": " Or the other? Okay, good. Correct the errors. You want to come? Fadhal you come. Start. Clean please.", "tokens": [1610, 264, 661, 30, 1033, 11, 665, 13, 12753, 264, 13603, 13, 509, 528, 281, 808, 30, 479, 345, 4947, 291, 808, 13, 6481, 13, 18463, 1767, 13], "avg_logprob": -0.3343211330216506, "compression_ratio": 1.096774193548387, "no_speech_prob": 0.0, "words": [{"start": 933.1099999999999, "end": 933.67, "word": " Or", "probability": 0.415771484375}, {"start": 933.67, "end": 933.85, "word": " the", "probability": 0.89111328125}, {"start": 933.85, "end": 934.07, "word": " other?", "probability": 0.884765625}, {"start": 934.27, "end": 934.47, "word": " Okay,", "probability": 0.61962890625}, {"start": 934.81, "end": 935.09, "word": " good.", "probability": 0.92236328125}, {"start": 947.11, "end": 947.67, "word": " Correct", "probability": 0.9501953125}, {"start": 947.67, "end": 947.93, "word": " the", "probability": 0.71435546875}, {"start": 947.93, "end": 948.21, "word": " errors.", "probability": 0.86962890625}, {"start": 951.27, "end": 951.45, "word": " You", "probability": 0.9326171875}, {"start": 951.45, "end": 951.69, "word": " want", "probability": 0.8916015625}, {"start": 951.69, "end": 951.85, "word": " to", "probability": 0.97509765625}, {"start": 951.85, "end": 952.11, "word": " come?", "probability": 0.833984375}, {"start": 952.55, "end": 952.89, "word": " Fadhal", "probability": 0.55126953125}, {"start": 952.89, "end": 952.97, "word": " you", "probability": 0.2218017578125}, {"start": 952.97, "end": 953.25, "word": " come.", "probability": 0.7939453125}, {"start": 953.91, "end": 954.47, "word": " Start.", "probability": 0.9404296875}, {"start": 960.35, "end": 960.91, "word": " Clean", "probability": 0.8544921875}, {"start": 960.91, "end": 961.41, "word": " please.", "probability": 0.630859375}], "temperature": 1.0}, {"id": 37, "seek": 99569, "start": 968.27, "end": 995.69, "text": " Use the red pen and clean also. Underline the error, then correct it. Where is the error? Okay, so we say what? Another, you are right. Another. Just a minute, just a minute. She did not finish. What do you think? Do you have something else?", "tokens": [8278, 264, 2182, 3435, 293, 2541, 611, 13, 6974, 1889, 264, 6713, 11, 550, 3006, 309, 13, 2305, 307, 264, 6713, 30, 1033, 11, 370, 321, 584, 437, 30, 3996, 11, 291, 366, 558, 13, 3996, 13, 1449, 257, 3456, 11, 445, 257, 3456, 13, 1240, 630, 406, 2413, 13, 708, 360, 291, 519, 30, 1144, 291, 362, 746, 1646, 30], "avg_logprob": -0.19417842501594174, "compression_ratio": 1.4666666666666666, "no_speech_prob": 0.0, "words": [{"start": 968.27, "end": 968.63, "word": " Use", "probability": 0.68310546875}, {"start": 968.63, "end": 968.81, "word": " the", "probability": 0.884765625}, {"start": 968.81, "end": 968.97, "word": " red", "probability": 0.921875}, {"start": 968.97, "end": 969.31, "word": " pen", "probability": 0.95458984375}, {"start": 969.31, "end": 969.65, "word": " and", "probability": 0.64208984375}, {"start": 969.65, "end": 970.89, "word": " clean", "probability": 0.5673828125}, {"start": 970.89, "end": 971.45, "word": " also.", "probability": 0.78271484375}, {"start": 972.77, "end": 973.29, "word": " Underline", "probability": 0.980712890625}, {"start": 973.29, "end": 973.67, "word": " the", "probability": 0.92236328125}, {"start": 973.67, "end": 973.97, "word": " error,", "probability": 0.89990234375}, {"start": 974.27, "end": 974.51, "word": " then", "probability": 0.83447265625}, {"start": 974.51, "end": 974.95, "word": " correct", "probability": 0.8955078125}, {"start": 974.95, "end": 975.23, "word": " it.", "probability": 0.951171875}, {"start": 975.49, "end": 975.63, "word": " Where", "probability": 0.78955078125}, {"start": 975.63, "end": 975.83, "word": " is", "probability": 0.9189453125}, {"start": 975.83, "end": 975.93, "word": " the", "probability": 0.92138671875}, {"start": 975.93, "end": 976.13, "word": " error?", "probability": 0.9013671875}, {"start": 980.59, "end": 981.11, "word": " Okay,", "probability": 0.241455078125}, {"start": 983.71, "end": 983.95, "word": " so", "probability": 0.83251953125}, {"start": 983.95, "end": 984.07, "word": " we", "probability": 0.8876953125}, {"start": 984.07, "end": 984.33, "word": " say", "probability": 0.94482421875}, {"start": 984.33, "end": 984.67, "word": " what?", "probability": 0.94091796875}, {"start": 985.29, "end": 985.63, "word": " Another,", "probability": 0.783203125}, {"start": 985.77, "end": 985.87, "word": " you", "probability": 0.9189453125}, {"start": 985.87, "end": 986.03, "word": " are", "probability": 0.8154296875}, {"start": 986.03, "end": 986.35, "word": " right.", "probability": 0.91943359375}, {"start": 987.19, "end": 987.59, "word": " Another.", "probability": 0.7822265625}, {"start": 988.47, "end": 988.99, "word": " Just", "probability": 0.66845703125}, {"start": 988.99, "end": 989.17, "word": " a", "probability": 0.99755859375}, {"start": 989.17, "end": 989.39, "word": " minute,", "probability": 0.919921875}, {"start": 989.59, "end": 989.77, "word": " just", "probability": 0.7724609375}, {"start": 989.77, "end": 989.97, "word": " a", "probability": 0.99853515625}, {"start": 989.97, "end": 990.17, "word": " minute.", "probability": 0.93359375}, {"start": 990.41, "end": 990.55, "word": " She", "probability": 0.8720703125}, {"start": 990.55, "end": 990.73, "word": " did", "probability": 0.9462890625}, {"start": 990.73, "end": 990.91, "word": " not", "probability": 0.94921875}, {"start": 990.91, "end": 991.31, "word": " finish.", "probability": 0.9658203125}, {"start": 992.13, "end": 992.47, "word": " What", "probability": 0.3857421875}, {"start": 992.47, "end": 994.19, "word": " do", "probability": 0.95849609375}, {"start": 994.19, "end": 994.29, "word": " you", "probability": 0.9658203125}, {"start": 994.29, "end": 994.51, "word": " think?", "probability": 0.91552734375}, {"start": 994.57, "end": 994.67, "word": " Do", "probability": 0.96435546875}, {"start": 994.67, "end": 994.75, "word": " you", "probability": 0.96337890625}, {"start": 994.75, "end": 994.93, "word": " have", "probability": 0.94921875}, {"start": 994.93, "end": 995.29, "word": " something", "probability": 0.8544921875}, {"start": 995.29, "end": 995.69, "word": " else?", "probability": 0.935546875}], "temperature": 1.0}, {"id": 38, "seek": 101626, "start": 996.18, "end": 1016.26, "text": " Yeah, we say what? Cold weather. Okay, just drop it. Okay, thank you. Good. Yes, please. I like to travel because I like to learn about other countries and customs. You are right. Good.", "tokens": [865, 11, 321, 584, 437, 30, 16918, 5503, 13, 1033, 11, 445, 3270, 309, 13, 1033, 11, 1309, 291, 13, 2205, 13, 1079, 11, 1767, 13, 286, 411, 281, 3147, 570, 286, 411, 281, 1466, 466, 661, 3517, 293, 27330, 13, 509, 366, 558, 13, 2205, 13], "avg_logprob": -0.2294921875, "compression_ratio": 1.3478260869565217, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 996.18, "end": 996.58, "word": " Yeah,", "probability": 0.274169921875}, {"start": 998.04, "end": 998.12, "word": " we", "probability": 0.392822265625}, {"start": 998.12, "end": 998.44, "word": " say", "probability": 0.9326171875}, {"start": 998.44, "end": 998.78, "word": " what?", "probability": 0.93408203125}, {"start": 999.0, "end": 999.28, "word": " Cold", "probability": 0.87158203125}, {"start": 999.28, "end": 1000.26, "word": " weather.", "probability": 0.9462890625}, {"start": 1000.56, "end": 1000.72, "word": " Okay,", "probability": 0.5126953125}, {"start": 1000.84, "end": 1001.08, "word": " just", "probability": 0.80517578125}, {"start": 1001.08, "end": 1001.44, "word": " drop", "probability": 0.8271484375}, {"start": 1001.44, "end": 1001.64, "word": " it.", "probability": 0.9560546875}, {"start": 1001.78, "end": 1001.94, "word": " Okay,", "probability": 0.66552734375}, {"start": 1002.04, "end": 1002.22, "word": " thank", "probability": 0.8447265625}, {"start": 1002.22, "end": 1002.54, "word": " you.", "probability": 0.9658203125}, {"start": 1002.66, "end": 1003.24, "word": " Good.", "probability": 0.77587890625}, {"start": 1003.64, "end": 1003.86, "word": " Yes,", "probability": 0.9599609375}, {"start": 1003.96, "end": 1004.28, "word": " please.", "probability": 0.822265625}, {"start": 1005.92, "end": 1005.94, "word": " I", "probability": 0.224853515625}, {"start": 1005.94, "end": 1009.0, "word": " like", "probability": 0.88818359375}, {"start": 1009.0, "end": 1009.16, "word": " to", "probability": 0.962890625}, {"start": 1009.16, "end": 1009.46, "word": " travel", "probability": 0.8740234375}, {"start": 1009.46, "end": 1009.98, "word": " because", "probability": 0.8818359375}, {"start": 1009.98, "end": 1010.3, "word": " I", "probability": 0.99267578125}, {"start": 1010.3, "end": 1010.74, "word": " like", "probability": 0.91845703125}, {"start": 1010.74, "end": 1011.16, "word": " to", "probability": 0.9580078125}, {"start": 1011.16, "end": 1011.36, "word": " learn", "probability": 0.978515625}, {"start": 1011.36, "end": 1011.68, "word": " about", "probability": 0.89892578125}, {"start": 1011.68, "end": 1012.32, "word": " other", "probability": 0.875}, {"start": 1012.32, "end": 1013.08, "word": " countries", "probability": 0.78955078125}, {"start": 1013.08, "end": 1014.1, "word": " and", "probability": 0.8583984375}, {"start": 1014.1, "end": 1014.76, "word": " customs.", "probability": 0.90283203125}, {"start": 1014.96, "end": 1015.1, "word": " You", "probability": 0.9267578125}, {"start": 1015.1, "end": 1015.28, "word": " are", "probability": 0.615234375}, {"start": 1015.28, "end": 1015.62, "word": " right.", "probability": 0.921875}, {"start": 1015.98, "end": 1016.26, "word": " Good.", "probability": 0.8798828125}], "temperature": 1.0}, {"id": 39, "seek": 105289, "start": 1024.43, "end": 1052.89, "text": " Other countries. Okay, good. And customs. Yes, please come. The new. Collecting stamps is one of my hobbies. Collecting stamps is one of my hobbies. Good. Thank you.", "tokens": [5358, 3517, 13, 1033, 11, 665, 13, 400, 27330, 13, 1079, 11, 1767, 808, 13, 440, 777, 13, 31896, 278, 30800, 307, 472, 295, 452, 35750, 13, 31896, 278, 30800, 307, 472, 295, 452, 35750, 13, 2205, 13, 1044, 291, 13], "avg_logprob": -0.22953868976661138, "compression_ratio": 1.4434782608695653, "no_speech_prob": 0.0, "words": [{"start": 1024.43, "end": 1024.81, "word": " Other", "probability": 0.83642578125}, {"start": 1024.81, "end": 1025.37, "word": " countries.", "probability": 0.81640625}, {"start": 1025.73, "end": 1025.85, "word": " Okay,", "probability": 0.75439453125}, {"start": 1026.01, "end": 1026.23, "word": " good.", "probability": 0.9248046875}, {"start": 1026.55, "end": 1026.77, "word": " And", "probability": 0.8056640625}, {"start": 1026.77, "end": 1027.15, "word": " customs.", "probability": 0.87255859375}, {"start": 1027.37, "end": 1027.53, "word": " Yes,", "probability": 0.9580078125}, {"start": 1027.67, "end": 1027.91, "word": " please", "probability": 0.80859375}, {"start": 1027.91, "end": 1028.25, "word": " come.", "probability": 0.420166015625}, {"start": 1028.51, "end": 1028.65, "word": " The", "probability": 0.51513671875}, {"start": 1028.65, "end": 1028.85, "word": " new.", "probability": 0.8017578125}, {"start": 1042.67, "end": 1043.31, "word": " Collecting", "probability": 0.78271484375}, {"start": 1043.31, "end": 1044.03, "word": " stamps", "probability": 0.9462890625}, {"start": 1044.03, "end": 1044.33, "word": " is", "probability": 0.86279296875}, {"start": 1044.33, "end": 1044.61, "word": " one", "probability": 0.92626953125}, {"start": 1044.61, "end": 1044.93, "word": " of", "probability": 0.96826171875}, {"start": 1044.93, "end": 1045.31, "word": " my", "probability": 0.974609375}, {"start": 1045.31, "end": 1046.03, "word": " hobbies.", "probability": 0.666015625}, {"start": 1047.87, "end": 1048.51, "word": " Collecting", "probability": 0.6484375}, {"start": 1048.51, "end": 1049.03, "word": " stamps", "probability": 0.923828125}, {"start": 1049.03, "end": 1049.39, "word": " is", "probability": 0.9453125}, {"start": 1049.39, "end": 1049.63, "word": " one", "probability": 0.93310546875}, {"start": 1049.63, "end": 1049.83, "word": " of", "probability": 0.9716796875}, {"start": 1049.83, "end": 1050.25, "word": " my", "probability": 0.9658203125}, {"start": 1050.25, "end": 1050.81, "word": " hobbies.", "probability": 0.708984375}, {"start": 1051.09, "end": 1051.73, "word": " Good.", "probability": 0.71826171875}, {"start": 1052.23, "end": 1052.63, "word": " Thank", "probability": 0.900390625}, {"start": 1052.63, "end": 1052.89, "word": " you.", "probability": 0.96142578125}], "temperature": 1.0}, {"id": 40, "seek": 107997, "start": 1055.53, "end": 1079.97, "text": " thank you next one yeah okay it should be in the plural go on read read the sentence i think", "tokens": [1309, 291, 958, 472, 1338, 1392, 309, 820, 312, 294, 264, 25377, 352, 322, 1401, 1401, 264, 8174, 741, 519], "avg_logprob": -0.24051339853377568, "compression_ratio": 1.2077922077922079, "no_speech_prob": 0.0, "words": [{"start": 1055.53, "end": 1055.81, "word": " thank", "probability": 0.10955810546875}, {"start": 1055.81, "end": 1056.11, "word": " you", "probability": 0.962890625}, {"start": 1056.11, "end": 1057.11, "word": " next", "probability": 0.72509765625}, {"start": 1057.11, "end": 1057.49, "word": " one", "probability": 0.94287109375}, {"start": 1057.49, "end": 1058.19, "word": " yeah", "probability": 0.703125}, {"start": 1058.19, "end": 1071.57, "word": " okay", "probability": 0.6328125}, {"start": 1071.57, "end": 1075.97, "word": " it", "probability": 0.9462890625}, {"start": 1075.97, "end": 1076.13, "word": " should", "probability": 0.96533203125}, {"start": 1076.13, "end": 1076.29, "word": " be", "probability": 0.95849609375}, {"start": 1076.29, "end": 1076.43, "word": " in", "probability": 0.95751953125}, {"start": 1076.43, "end": 1076.55, "word": " the", "probability": 0.921875}, {"start": 1076.55, "end": 1076.87, "word": " plural", "probability": 0.97900390625}, {"start": 1076.87, "end": 1077.53, "word": " go", "probability": 0.92236328125}, {"start": 1077.53, "end": 1077.95, "word": " on", "probability": 0.94873046875}, {"start": 1077.95, "end": 1078.47, "word": " read", "probability": 0.962890625}, {"start": 1078.47, "end": 1078.75, "word": " read", "probability": 0.888671875}, {"start": 1078.75, "end": 1078.97, "word": " the", "probability": 0.9248046875}, {"start": 1078.97, "end": 1079.33, "word": " sentence", "probability": 0.94677734375}, {"start": 1079.33, "end": 1079.57, "word": " i", "probability": 0.6123046875}, {"start": 1079.57, "end": 1079.97, "word": " think", "probability": 0.921875}], "temperature": 1.0}, {"id": 41, "seek": 110856, "start": 1084.66, "end": 1108.56, "text": " What do you think? Just a minute. Now, look, this is progress. What type of nouns? Non-count. 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A pen, a car, okay, a class, and so on. So can we use it with an uncount now? No. So it should be what? Deleted. Thank you. Good. Next one. 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Fourteen. Okay, fourteen. Who wants fourteen for you? Fifteen? Okay, for you, sixteen for you, seventeen for you, eighteen, nineteen, and the last one for you. Okay, so keep your numbers, please. 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Number what now? Seven. 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All of other students. Now, okay, I go to the class all of the other students. Of the other. Thank you. Yes, I gave you the numbers. You know why? To come one", "tokens": [1057, 295, 661, 1731, 13, 1057, 295, 661, 1731, 13, 823, 11, 1392, 11, 286, 352, 281, 264, 1508, 439, 295, 264, 661, 1731, 13, 2720, 264, 661, 13, 1044, 291, 13, 1079, 11, 286, 2729, 291, 264, 3547, 13, 509, 458, 983, 30, 1407, 808, 472], "avg_logprob": -0.2718098871409893, "compression_ratio": 1.5041322314049588, "no_speech_prob": 0.0, "words": [{"start": 1222.34, "end": 1222.8, "word": " All", "probability": 0.29736328125}, {"start": 1222.8, "end": 1223.34, "word": " of", "probability": 0.8974609375}, {"start": 1223.34, "end": 1223.84, "word": " other", "probability": 0.5078125}, {"start": 1223.84, "end": 1224.56, "word": " students.", "probability": 0.9697265625}, {"start": 1226.18, "end": 1226.88, "word": " All", "probability": 0.48779296875}, {"start": 1226.88, "end": 1227.04, "word": " of", "probability": 0.9541015625}, {"start": 1227.04, "end": 1227.32, "word": " other", "probability": 0.828125}, {"start": 1227.32, "end": 1227.9, "word": " students.", "probability": 0.97265625}, {"start": 1228.24, "end": 1228.24, "word": " Now,", "probability": 0.64990234375}, {"start": 1228.78, "end": 1229.02, "word": " okay,", "probability": 0.6328125}, {"start": 1229.08, "end": 1229.24, "word": " I", "probability": 0.98193359375}, {"start": 1229.24, "end": 1229.42, "word": " go", "probability": 0.6376953125}, {"start": 1229.42, "end": 1229.56, "word": " to", "probability": 0.95068359375}, {"start": 1229.56, "end": 1229.74, "word": " the", "probability": 0.8359375}, {"start": 1229.74, "end": 1230.1, "word": " class", "probability": 0.9658203125}, {"start": 1230.1, "end": 1230.52, "word": " all", "probability": 0.340576171875}, {"start": 1230.52, "end": 1231.36, "word": " of", "probability": 0.9521484375}, {"start": 1231.36, "end": 1231.48, "word": " the", "probability": 0.8837890625}, {"start": 1231.48, "end": 1231.74, "word": " other", "probability": 0.88720703125}, {"start": 1231.74, "end": 1232.36, "word": " students.", "probability": 0.97265625}, {"start": 1234.28, "end": 1234.98, "word": " Of", "probability": 0.62548828125}, {"start": 1234.98, "end": 1235.14, "word": " the", "probability": 0.923828125}, {"start": 1235.14, "end": 1235.38, "word": " other.", "probability": 0.78515625}, {"start": 1235.64, "end": 1235.96, "word": " Thank", "probability": 0.83251953125}, {"start": 1235.96, "end": 1236.22, "word": " you.", "probability": 0.95654296875}, {"start": 1238.98, "end": 1239.64, "word": " Yes,", "probability": 0.9189453125}, {"start": 1239.7, "end": 1239.84, "word": " I", "probability": 0.99853515625}, {"start": 1239.84, "end": 1240.06, "word": " gave", "probability": 0.6630859375}, {"start": 1240.06, "end": 1240.2, "word": " you", "probability": 0.96240234375}, {"start": 1240.2, "end": 1240.38, "word": " the", "probability": 0.91650390625}, {"start": 1240.38, "end": 1240.78, "word": " numbers.", "probability": 0.87744140625}, {"start": 1241.26, "end": 1241.78, "word": " You", "probability": 0.85498046875}, {"start": 1241.78, "end": 1241.96, "word": " know", "probability": 0.89794921875}, {"start": 1241.96, "end": 1242.36, "word": " why?", "probability": 0.90673828125}, {"start": 1243.6, "end": 1243.82, "word": " To", "probability": 0.89501953125}, {"start": 1243.82, "end": 1244.2, "word": " come", "probability": 0.587890625}, {"start": 1244.2, "end": 1245.02, "word": " one", "probability": 0.650390625}], "temperature": 1.0}, {"id": 47, "seek": 127235, "start": 1246.0, "end": 1272.36, "text": "After the other. Okay, or one after another. Okay, go on. Okay, thank you. Good. From other languages.", "tokens": [24288, 264, 661, 13, 1033, 11, 420, 472, 934, 1071, 13, 1033, 11, 352, 322, 13, 1033, 11, 1309, 291, 13, 2205, 13, 3358, 661, 8650, 13], "avg_logprob": -0.31110490219933645, "compression_ratio": 1.2289156626506024, "no_speech_prob": 0.0, "words": [{"start": 1246.0, "end": 1246.52, "word": "After", "probability": 0.212646484375}, {"start": 1246.52, "end": 1247.36, "word": " the", "probability": 0.72705078125}, {"start": 1247.36, "end": 1247.7, "word": " other.", "probability": 0.89404296875}, {"start": 1248.32, "end": 1248.7, "word": " Okay,", "probability": 0.60205078125}, {"start": 1249.02, "end": 1249.18, "word": " or", "probability": 0.87744140625}, {"start": 1249.18, "end": 1249.48, "word": " one", "probability": 0.9296875}, {"start": 1249.48, "end": 1249.94, "word": " after", "probability": 0.85595703125}, {"start": 1249.94, "end": 1250.86, "word": " another.", "probability": 0.904296875}, {"start": 1251.14, "end": 1251.36, "word": " Okay,", "probability": 0.7958984375}, {"start": 1251.54, "end": 1251.72, "word": " go", "probability": 0.9599609375}, {"start": 1251.72, "end": 1252.12, "word": " on.", "probability": 0.95166015625}, {"start": 1263.68, "end": 1264.36, "word": " Okay,", "probability": 0.1849365234375}, {"start": 1270.02, "end": 1270.26, "word": " thank", "probability": 0.80615234375}, {"start": 1270.26, "end": 1270.52, "word": " you.", "probability": 0.96484375}, {"start": 1270.68, "end": 1270.86, "word": " Good.", "probability": 0.8173828125}, {"start": 1271.22, "end": 1271.48, "word": " From", "probability": 0.73974609375}, {"start": 1271.48, "end": 1271.86, "word": " other", "probability": 0.888671875}, {"start": 1271.86, "end": 1272.36, "word": " languages.", "probability": 0.96826171875}], "temperature": 1.0}, {"id": 48, "seek": 130889, "start": 1294.57, "end": 1308.89, "text": " Okay, so you said there are many students from different countries. Good, thank you, in this class. Next one. Where is number ten?", "tokens": [1033, 11, 370, 291, 848, 456, 366, 867, 1731, 490, 819, 3517, 13, 2205, 11, 1309, 291, 11, 294, 341, 1508, 13, 3087, 472, 13, 2305, 307, 1230, 2064, 30], "avg_logprob": -0.22555444029069716, "compression_ratio": 1.190909090909091, "no_speech_prob": 0.0, "words": [{"start": 1294.5700000000002, "end": 1295.15, "word": " Okay,", "probability": 0.24658203125}, {"start": 1295.15, "end": 1295.73, "word": " so", "probability": 0.8623046875}, {"start": 1295.73, "end": 1295.99, "word": " you", "probability": 0.9306640625}, {"start": 1295.99, "end": 1296.23, "word": " said", "probability": 0.9326171875}, {"start": 1296.23, "end": 1296.47, "word": " there", "probability": 0.82373046875}, {"start": 1296.47, "end": 1296.71, "word": " are", "probability": 0.9453125}, {"start": 1296.71, "end": 1297.05, "word": " many", "probability": 0.908203125}, {"start": 1297.05, "end": 1297.63, "word": " students", "probability": 0.9755859375}, {"start": 1297.63, "end": 1298.01, "word": " from", "probability": 0.86669921875}, {"start": 1298.01, "end": 1298.45, "word": " different", "probability": 0.884765625}, {"start": 1298.45, "end": 1298.91, "word": " countries.", "probability": 0.7763671875}, {"start": 1299.05, "end": 1299.19, "word": " Good,", "probability": 0.8681640625}, {"start": 1299.35, "end": 1299.55, "word": " thank", "probability": 0.84765625}, {"start": 1299.55, "end": 1299.69, "word": " you,", "probability": 0.96435546875}, {"start": 1299.75, "end": 1299.83, "word": " in", "probability": 0.59765625}, {"start": 1299.83, "end": 1299.97, "word": " this", "probability": 0.94921875}, {"start": 1299.97, "end": 1300.39, "word": " class.", "probability": 0.970703125}, {"start": 1301.03, "end": 1301.25, "word": " Next", "probability": 0.91357421875}, {"start": 1301.25, "end": 1301.57, "word": " one.", "probability": 0.93798828125}, {"start": 1304.61, "end": 1304.97, "word": " Where", "probability": 0.77490234375}, {"start": 1304.97, "end": 1308.33, "word": " is", "probability": 0.93212890625}, {"start": 1308.33, "end": 1308.55, "word": " number", "probability": 0.90478515625}, {"start": 1308.55, "end": 1308.89, "word": " ten?", "probability": 0.480712890625}], "temperature": 1.0}, {"id": 49, "seek": 133186, "start": 1310.7, "end": 1331.86, "text": " Okay, let me write it for you. Clean the board please. Thousand of athletes take part in the Olympics. Take part in the Olympics. Okay.", "tokens": [1033, 11, 718, 385, 2464, 309, 337, 291, 13, 18463, 264, 3150, 1767, 13, 29852, 474, 295, 13820, 747, 644, 294, 264, 19854, 13, 3664, 644, 294, 264, 19854, 13, 1033, 13], "avg_logprob": -0.2990056818181818, "compression_ratio": 1.3333333333333333, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1310.7, "end": 1311.08, "word": " Okay,", "probability": 0.61572265625}, {"start": 1311.34, "end": 1311.56, "word": " let", "probability": 0.951171875}, {"start": 1311.56, "end": 1311.7, "word": " me", "probability": 0.97265625}, {"start": 1311.7, "end": 1311.98, "word": " write", "probability": 0.92431640625}, {"start": 1311.98, "end": 1312.1, "word": " it", "probability": 0.94970703125}, {"start": 1312.1, "end": 1312.32, "word": " for", "probability": 0.953125}, {"start": 1312.32, "end": 1312.66, "word": " you.", "probability": 0.96826171875}, {"start": 1313.3, "end": 1313.56, "word": " Clean", "probability": 0.88232421875}, {"start": 1313.56, "end": 1313.76, "word": " the", "probability": 0.5791015625}, {"start": 1313.76, "end": 1314.12, "word": " board", "probability": 0.96044921875}, {"start": 1314.12, "end": 1314.68, "word": " please.", "probability": 0.49365234375}, {"start": 1315.94, "end": 1316.66, "word": " Thousand", "probability": 0.7171630859375}, {"start": 1316.66, "end": 1318.86, "word": " of", "probability": 0.310791015625}, {"start": 1318.86, "end": 1319.46, "word": " athletes", "probability": 0.74609375}, {"start": 1319.46, "end": 1324.44, "word": " take", "probability": 0.6357421875}, {"start": 1324.44, "end": 1325.0, "word": " part", "probability": 0.91455078125}, {"start": 1325.0, "end": 1327.14, "word": " in", "probability": 0.93359375}, {"start": 1327.14, "end": 1327.3, "word": " the", "probability": 0.9140625}, {"start": 1327.3, "end": 1327.66, "word": " Olympics.", "probability": 0.94189453125}, {"start": 1329.22, "end": 1329.94, "word": " Take", "probability": 0.62890625}, {"start": 1329.94, "end": 1330.48, "word": " part", "probability": 0.9072265625}, {"start": 1330.48, "end": 1330.9, "word": " in", "probability": 0.21484375}, {"start": 1330.9, "end": 1331.02, "word": " the", "probability": 0.90771484375}, {"start": 1331.02, "end": 1331.3, "word": " Olympics.", "probability": 0.81640625}, {"start": 1331.6, "end": 1331.86, "word": " Okay.", "probability": 0.79736328125}], "temperature": 1.0}, {"id": 50, "seek": 136914, "start": 1341.86, "end": 1369.14, "text": " With S or without S? With S. Yeah, go on please now. We must just add S. Thousand. Okay, what about thousand? It is thousands. Okay, now when do we usually use S with thousand, hundred, million? When do we usually use S? 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But if they are preceded by numbers, we should not use this. Next one, eleven.", "tokens": [1079, 11, 321, 434, 406, 16969, 292, 538, 3547, 11, 1392, 30, 583, 498, 436, 366, 16969, 292, 538, 3547, 11, 321, 820, 406, 764, 341, 13, 3087, 472, 11, 21090, 13], "avg_logprob": -0.2547348484848485, "compression_ratio": 1.2736842105263158, "no_speech_prob": 0.0, "words": [{"start": 1370.35, "end": 1370.73, "word": " Yes,", "probability": 0.6435546875}, {"start": 1370.93, "end": 1371.11, "word": " we're", "probability": 0.642578125}, {"start": 1371.11, "end": 1371.33, "word": " not", "probability": 0.93896484375}, {"start": 1371.33, "end": 1371.87, "word": " preceded", "probability": 0.9580078125}, {"start": 1371.87, "end": 1372.07, "word": " by", "probability": 0.9736328125}, {"start": 1372.07, "end": 1372.53, "word": " numbers,", "probability": 0.91650390625}, {"start": 1372.75, "end": 1373.01, "word": " okay?", "probability": 0.74755859375}, {"start": 1373.41, "end": 1373.79, "word": " But", "probability": 0.85791015625}, {"start": 1373.79, "end": 1374.03, "word": " if", "probability": 0.9228515625}, {"start": 1374.03, "end": 1374.19, "word": " they", "probability": 0.88916015625}, {"start": 1374.19, "end": 1374.37, "word": " are", "probability": 0.859375}, {"start": 1374.37, "end": 1374.89, "word": " preceded", "probability": 0.9345703125}, {"start": 1374.89, "end": 1375.09, "word": " by", "probability": 0.97216796875}, {"start": 1375.09, "end": 1375.63, "word": " numbers,", "probability": 0.9189453125}, {"start": 1375.75, "end": 1376.03, "word": " we", "probability": 0.479736328125}, {"start": 1376.03, "end": 1377.67, "word": " should", "probability": 0.33203125}, {"start": 1377.67, "end": 1377.97, "word": " not", "probability": 0.9345703125}, {"start": 1377.97, "end": 1378.31, "word": " use", "probability": 0.85791015625}, {"start": 1378.31, "end": 1378.65, "word": " this.", "probability": 0.74462890625}, {"start": 1387.29, "end": 1387.97, "word": " Next", "probability": 0.88525390625}, {"start": 1387.97, "end": 1388.37, "word": " one,", "probability": 0.93701171875}, {"start": 1388.81, "end": 1389.17, "word": " eleven.", "probability": 0.509765625}], "temperature": 1.0}, {"id": 52, "seek": 143015, "start": 1400.81, "end": 1430.15, "text": " Yeah, eleven. Yeah, come please. Education is one of the most important aspects of life. Knowledge is knowledge. Okay, doesn't accept the S. Doesn't accept the S, eleven. 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What about aspect? Yes, knowledge allows. You are right. Good. Knowledge allows. Now, what do you think of important? Good. Thank you. 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Okay. All of the students' names. Good, thank you. Before or after the S? After the S. Good, because it is? Plura. Plura. Thank you very much. Number 13. Okay, come. 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Now, I live in a two-room apartment. What do you think of the S? Drop the S. Okay. Now, this is a noun, a compound, noun modifier. Okay? 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It should be hyphenated. This is a hyphen. And we don't use what? Plural. We say a two-room apartment. Next one. 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So many people, good, to their communities prevents them. You are right. Thank you. Works. Sorry? Yes, what do you think in search of work? What do you think of works? What do you think of this word?", "tokens": [6001, 85, 791, 552, 13, 407, 867, 561, 11, 665, 11, 281, 641, 4456, 22367, 552, 13, 509, 366, 558, 13, 1044, 291, 13, 27914, 13, 4919, 30, 1079, 11, 437, 360, 291, 519, 294, 3164, 295, 589, 30, 708, 360, 291, 519, 295, 1985, 30, 708, 360, 291, 519, 295, 341, 1349, 30], "avg_logprob": -0.23366477381099354, "compression_ratio": 1.5808823529411764, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1555.42, "end": 1555.98, "word": " Prevents", "probability": 0.6524658203125}, {"start": 1555.98, "end": 1556.34, "word": " them.", "probability": 0.89892578125}, {"start": 1557.96, "end": 1558.52, "word": " So", "probability": 0.71435546875}, {"start": 1558.52, "end": 1559.12, "word": " many", "probability": 0.62890625}, {"start": 1559.12, "end": 1559.88, "word": " people,", "probability": 0.96875}, {"start": 1560.1, "end": 1560.72, "word": " good,", "probability": 0.8359375}, {"start": 1561.82, "end": 1562.6, "word": " to", "probability": 0.953125}, {"start": 1562.6, "end": 1562.86, "word": " their", "probability": 0.95703125}, {"start": 1562.86, "end": 1563.5, "word": " communities", "probability": 0.970703125}, {"start": 1563.5, "end": 1564.04, "word": " prevents", "probability": 0.6123046875}, {"start": 1564.04, "end": 1564.4, "word": " them.", "probability": 0.89697265625}, {"start": 1564.56, "end": 1564.66, "word": " You", "probability": 0.9365234375}, {"start": 1564.66, "end": 1564.8, "word": " are", "probability": 0.86767578125}, {"start": 1564.8, "end": 1565.12, "word": " right.", "probability": 0.9189453125}, {"start": 1565.36, "end": 1565.58, "word": " Thank", "probability": 0.84033203125}, {"start": 1565.58, "end": 1566.86, "word": " you.", "probability": 0.958984375}, {"start": 1567.06, "end": 1567.62, "word": " Works.", "probability": 0.58056640625}, {"start": 1568.06, "end": 1568.36, "word": " Sorry?", "probability": 0.61083984375}, {"start": 1569.3, "end": 1569.86, "word": " Yes,", "probability": 0.318359375}, {"start": 1570.22, "end": 1570.36, "word": " what", "probability": 0.8564453125}, {"start": 1570.36, "end": 1570.44, "word": " do", "probability": 0.95703125}, {"start": 1570.44, "end": 1570.56, "word": " you", "probability": 0.96484375}, {"start": 1570.56, "end": 1570.84, "word": " think", "probability": 0.921875}, {"start": 1570.84, "end": 1571.08, "word": " in", "probability": 0.7646484375}, {"start": 1571.08, "end": 1571.42, "word": " search", "probability": 0.9716796875}, {"start": 1571.42, "end": 1571.66, "word": " of", "probability": 0.9658203125}, {"start": 1571.66, "end": 1572.04, "word": " work?", "probability": 0.91015625}, {"start": 1572.42, "end": 1572.7, "word": " What", "probability": 0.86181640625}, {"start": 1572.7, "end": 1572.8, "word": " do", "probability": 0.95263671875}, {"start": 1572.8, "end": 1572.9, "word": " you", "probability": 0.96240234375}, {"start": 1572.9, "end": 1573.16, "word": " think", "probability": 0.91845703125}, {"start": 1573.16, "end": 1573.36, "word": " of", "probability": 0.96044921875}, {"start": 1573.36, "end": 1573.76, "word": " works?", "probability": 0.859375}, {"start": 1573.9, "end": 1574.0, "word": " What", "probability": 0.84912109375}, {"start": 1574.0, "end": 1574.1, "word": " do", "probability": 0.9521484375}, {"start": 1574.1, "end": 1574.18, "word": " you", "probability": 0.96044921875}, {"start": 1574.18, "end": 1574.38, "word": " think", "probability": 0.91748046875}, {"start": 1574.38, "end": 1574.52, "word": " of", "probability": 0.96240234375}, {"start": 1574.52, "end": 1574.72, "word": " this", "probability": 0.95166015625}, {"start": 1574.72, "end": 1574.92, "word": " word?", "probability": 0.87548828125}], "temperature": 1.0}, {"id": 58, "seek": 159480, "start": 1575.94, "end": 1594.8, "text": " Work. Why work, not works? Okay, good. Today's news is just as bad as yesterday's news. Okay, good. Thank you.", "tokens": [6603, 13, 1545, 589, 11, 406, 1985, 30, 1033, 11, 665, 13, 2692, 311, 2583, 307, 445, 382, 1578, 382, 5186, 311, 2583, 13, 1033, 11, 665, 13, 1044, 291, 13], "avg_logprob": -0.2313232417218387, "compression_ratio": 1.2333333333333334, "no_speech_prob": 0.0, "words": [{"start": 1575.94, "end": 1576.44, "word": " Work.", "probability": 0.77685546875}, {"start": 1576.56, "end": 1576.76, "word": " Why", "probability": 0.88232421875}, {"start": 1576.76, "end": 1577.18, "word": " work,", "probability": 0.91748046875}, {"start": 1577.24, "end": 1577.38, "word": " not", "probability": 0.927734375}, {"start": 1577.38, "end": 1577.84, "word": " works?", "probability": 0.85498046875}, {"start": 1578.38, "end": 1578.52, "word": " Okay,", "probability": 0.640625}, {"start": 1578.66, "end": 1578.88, "word": " good.", "probability": 0.9287109375}, {"start": 1585.36, "end": 1586.08, "word": " Today's", "probability": 0.817626953125}, {"start": 1586.08, "end": 1586.54, "word": " news", "probability": 0.86181640625}, {"start": 1586.54, "end": 1586.98, "word": " is", "probability": 0.93505859375}, {"start": 1586.98, "end": 1587.34, "word": " just", "probability": 0.9072265625}, {"start": 1587.34, "end": 1587.72, "word": " as", "probability": 0.95751953125}, {"start": 1587.72, "end": 1587.98, "word": " bad", "probability": 0.9443359375}, {"start": 1587.98, "end": 1588.3, "word": " as", "probability": 0.9609375}, {"start": 1588.3, "end": 1589.04, "word": " yesterday's", "probability": 0.93603515625}, {"start": 1589.04, "end": 1589.54, "word": " news.", "probability": 0.85546875}, {"start": 1592.36, "end": 1593.08, "word": " Okay,", "probability": 0.158447265625}, {"start": 1593.44, "end": 1593.74, "word": " good.", "probability": 0.92724609375}, {"start": 1594.3, "end": 1594.56, "word": " Thank", "probability": 0.9033203125}, {"start": 1594.56, "end": 1594.8, "word": " you.", "probability": 0.9619140625}], "temperature": 1.0}, {"id": 59, "seek": 163570, "start": 1613.02, "end": 1635.7, "text": " Almost all of the students speak. Thank you. Good. We can delete half. Just a minute. Yes. We can delete half. Almost the students. Almost all the students. Yeah. Good. But it is not an error. He says correct error. It is a good sentence. Yeah. 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Yeah, your turn. Is it for you? Seventeen, four, come. Okay, what did you do?", "tokens": [4534, 295, 264, 1731, 11, 309, 311, 611, 1392, 13, 865, 11, 428, 1261, 13, 1119, 309, 337, 291, 30, 28960, 29542, 11, 1451, 11, 808, 13, 1033, 11, 437, 630, 291, 360, 30], "avg_logprob": -0.26361607313156127, "compression_ratio": 1.1262135922330097, "no_speech_prob": 0.0, "words": [{"start": 1636.38, "end": 1636.88, "word": " Most", "probability": 0.77392578125}, {"start": 1636.88, "end": 1637.4, "word": " of", "probability": 0.94775390625}, {"start": 1637.4, "end": 1637.58, "word": " the", "probability": 0.91064453125}, {"start": 1637.58, "end": 1638.02, "word": " students,", "probability": 0.962890625}, {"start": 1638.14, "end": 1638.34, "word": " it's", "probability": 0.917724609375}, {"start": 1638.34, "end": 1638.64, "word": " also", "probability": 0.8583984375}, {"start": 1638.64, "end": 1638.98, "word": " okay.", "probability": 0.705078125}, {"start": 1640.1, "end": 1640.66, "word": " Yeah,", "probability": 0.52880859375}, {"start": 1641.4, "end": 1641.66, "word": " your", "probability": 0.87744140625}, {"start": 1641.66, "end": 1642.06, "word": " turn.", "probability": 0.82080078125}, {"start": 1642.92, "end": 1643.08, "word": " Is", "probability": 0.95703125}, {"start": 1643.08, "end": 1643.2, "word": " it", "probability": 0.95263671875}, {"start": 1643.2, "end": 1643.4, "word": " for", "probability": 0.9560546875}, {"start": 1643.4, "end": 1643.72, "word": " you?", "probability": 0.97265625}, {"start": 1644.76, "end": 1645.32, "word": " Seventeen,", "probability": 0.7001953125}, {"start": 1645.54, "end": 1645.76, "word": " four,", "probability": 0.9306640625}, {"start": 1645.96, "end": 1646.22, "word": " come.", "probability": 0.9033203125}, {"start": 1654.72, "end": 1655.28, "word": " Okay,", "probability": 0.296630859375}, {"start": 1664.26, "end": 1664.48, "word": " what", "probability": 0.94970703125}, {"start": 1664.48, "end": 1664.62, "word": " did", "probability": 0.93505859375}, {"start": 1664.62, "end": 1664.74, "word": " you", "probability": 0.96826171875}, {"start": 1664.74, "end": 1664.96, "word": " do?", "probability": 0.96826171875}], "temperature": 1.0}, {"id": 61, "seek": 168711, "start": 1670.53, "end": 1687.11, "text": " Several, a lot of homework. Good. It's a good answer. You know, a lot of is used with count and non-count. Good. Or several assignments. Please, one speaker, one speaker. Who's the speaker? Yeah.", "tokens": [22246, 11, 257, 688, 295, 14578, 13, 2205, 13, 467, 311, 257, 665, 1867, 13, 509, 458, 11, 257, 688, 295, 307, 1143, 365, 1207, 293, 2107, 12, 26050, 13, 2205, 13, 1610, 2940, 22546, 13, 2555, 11, 472, 8145, 11, 472, 8145, 13, 2102, 311, 264, 8145, 30, 865, 13], "avg_logprob": -0.3010817256111365, "compression_ratio": 1.4306569343065694, "no_speech_prob": 6.556510925292969e-07, "words": [{"start": 1670.53, "end": 1670.97, "word": " Several,", "probability": 0.229736328125}, {"start": 1671.33, "end": 1671.71, "word": " a", "probability": 0.9111328125}, {"start": 1671.71, "end": 1671.93, "word": " lot", "probability": 0.955078125}, {"start": 1671.93, "end": 1672.13, "word": " of", "probability": 0.958984375}, {"start": 1672.13, "end": 1672.45, "word": " homework.", "probability": 0.8896484375}, {"start": 1672.61, "end": 1672.81, "word": " Good.", "probability": 0.73095703125}, {"start": 1673.05, "end": 1673.25, "word": " It's", "probability": 0.9052734375}, {"start": 1673.25, "end": 1673.37, "word": " a", "probability": 0.99267578125}, {"start": 1673.37, "end": 1673.55, "word": " good", "probability": 0.92333984375}, {"start": 1673.55, "end": 1673.99, "word": " answer.", "probability": 0.958984375}, {"start": 1674.13, "end": 1674.17, "word": " You", "probability": 0.87890625}, {"start": 1674.17, "end": 1674.35, "word": " know,", "probability": 0.888671875}, {"start": 1674.45, "end": 1674.55, "word": " a", "probability": 0.86279296875}, {"start": 1674.55, "end": 1674.75, "word": " lot", "probability": 0.95361328125}, {"start": 1674.75, "end": 1674.93, "word": " of", "probability": 0.6962890625}, {"start": 1674.93, "end": 1675.13, "word": " is", "probability": 0.69970703125}, {"start": 1675.13, "end": 1675.39, "word": " used", "probability": 0.90966796875}, {"start": 1675.39, "end": 1675.61, "word": " with", "probability": 0.90380859375}, {"start": 1675.61, "end": 1675.99, "word": " count", "probability": 0.505859375}, {"start": 1675.99, "end": 1676.87, "word": " and", "probability": 0.66796875}, {"start": 1676.87, "end": 1677.09, "word": " non", "probability": 0.9375}, {"start": 1677.09, "end": 1677.49, "word": "-count.", "probability": 0.6246337890625}, {"start": 1677.75, "end": 1677.87, "word": " Good.", "probability": 0.79150390625}, {"start": 1678.23, "end": 1678.61, "word": " Or", "probability": 0.2406005859375}, {"start": 1678.61, "end": 1681.47, "word": " several", "probability": 0.70263671875}, {"start": 1681.47, "end": 1683.53, "word": " assignments.", "probability": 0.83056640625}, {"start": 1683.55, "end": 1683.81, "word": " Please,", "probability": 0.67578125}, {"start": 1683.99, "end": 1684.19, "word": " one", "probability": 0.93408203125}, {"start": 1684.19, "end": 1684.79, "word": " speaker,", "probability": 0.904296875}, {"start": 1685.03, "end": 1685.23, "word": " one", "probability": 0.89990234375}, {"start": 1685.23, "end": 1685.77, "word": " speaker.", "probability": 0.88037109375}, {"start": 1685.85, "end": 1686.05, "word": " Who's", "probability": 0.7587890625}, {"start": 1686.05, "end": 1686.21, "word": " the", "probability": 0.92333984375}, {"start": 1686.21, "end": 1686.59, "word": " speaker?", "probability": 0.880859375}, {"start": 1686.97, "end": 1687.11, "word": " Yeah.", "probability": 0.546875}], "temperature": 1.0}, {"id": 62, "seek": 171465, "start": 1690.15, "end": 1714.65, "text": " We can say some homework. Very good. You are right. And now we want to keep several, several homework, several homework assignments. Very good. Several homework assignments. Thank you. Good. So you can say some homework also and you can say several homework assignments. Very good. Next one.", "tokens": [492, 393, 584, 512, 14578, 13, 4372, 665, 13, 509, 366, 558, 13, 400, 586, 321, 528, 281, 1066, 2940, 11, 2940, 14578, 11, 2940, 14578, 22546, 13, 4372, 665, 13, 22246, 14578, 22546, 13, 1044, 291, 13, 2205, 13, 407, 291, 393, 584, 512, 14578, 611, 293, 291, 393, 584, 2940, 14578, 22546, 13, 4372, 665, 13, 3087, 472, 13], "avg_logprob": -0.19216229838709678, "compression_ratio": 2.085714285714286, "no_speech_prob": 0.0, "words": [{"start": 1690.15, "end": 1690.41, "word": " We", "probability": 0.254150390625}, {"start": 1690.41, "end": 1690.73, "word": " can", "probability": 0.947265625}, {"start": 1690.73, "end": 1690.95, "word": " say", "probability": 0.94482421875}, {"start": 1690.95, "end": 1691.27, "word": " some", "probability": 0.74169921875}, {"start": 1691.27, "end": 1691.63, "word": " homework.", "probability": 0.896484375}, {"start": 1691.85, "end": 1691.99, "word": " Very", "probability": 0.79638671875}, {"start": 1691.99, "end": 1692.19, "word": " good.", "probability": 0.9208984375}, {"start": 1692.27, "end": 1692.35, "word": " You", "probability": 0.939453125}, {"start": 1692.35, "end": 1692.49, "word": " are", "probability": 0.8408203125}, {"start": 1692.49, "end": 1692.79, "word": " right.", "probability": 0.92041015625}, {"start": 1693.63, "end": 1693.83, "word": " And", "probability": 0.83251953125}, {"start": 1693.83, "end": 1694.53, "word": " now", "probability": 0.89501953125}, {"start": 1694.53, "end": 1694.75, "word": " we", "probability": 0.8330078125}, {"start": 1694.75, "end": 1695.01, "word": " want", "probability": 0.88916015625}, {"start": 1695.01, "end": 1695.15, "word": " to", "probability": 0.9736328125}, {"start": 1695.15, "end": 1695.41, "word": " keep", "probability": 0.89599609375}, {"start": 1695.41, "end": 1695.93, "word": " several,", "probability": 0.88623046875}, {"start": 1696.07, "end": 1697.25, "word": " several", "probability": 0.8212890625}, {"start": 1697.25, "end": 1697.85, "word": " homework,", "probability": 0.8974609375}, {"start": 1698.27, "end": 1700.01, "word": " several", "probability": 0.68798828125}, {"start": 1700.01, "end": 1701.03, "word": " homework", "probability": 0.53369140625}, {"start": 1701.03, "end": 1702.25, "word": " assignments.", "probability": 0.9404296875}, {"start": 1702.59, "end": 1702.71, "word": " Very", "probability": 0.7734375}, {"start": 1702.71, "end": 1702.91, "word": " good.", "probability": 0.91796875}, {"start": 1703.19, "end": 1703.51, "word": " Several", "probability": 0.65576171875}, {"start": 1703.51, "end": 1704.09, "word": " homework", "probability": 0.87109375}, {"start": 1704.09, "end": 1704.99, "word": " assignments.", "probability": 0.94140625}, {"start": 1705.41, "end": 1705.63, "word": " Thank", "probability": 0.88232421875}, {"start": 1705.63, "end": 1705.85, "word": " you.", "probability": 0.95947265625}, {"start": 1705.93, "end": 1706.07, "word": " Good.", "probability": 0.8603515625}, {"start": 1706.39, "end": 1706.51, "word": " So", "probability": 0.9619140625}, {"start": 1706.51, "end": 1706.73, "word": " you", "probability": 0.84228515625}, {"start": 1706.73, "end": 1706.99, "word": " can", "probability": 0.94921875}, {"start": 1706.99, "end": 1707.19, "word": " say", "probability": 0.931640625}, {"start": 1707.19, "end": 1707.49, "word": " some", "probability": 0.8779296875}, {"start": 1707.49, "end": 1707.87, "word": " homework", "probability": 0.861328125}, {"start": 1707.87, "end": 1708.47, "word": " also", "probability": 0.86962890625}, {"start": 1708.47, "end": 1709.03, "word": " and", "probability": 0.53759765625}, {"start": 1709.03, "end": 1709.21, "word": " you", "probability": 0.96337890625}, {"start": 1709.21, "end": 1709.47, "word": " can", "probability": 0.95068359375}, {"start": 1709.47, "end": 1709.67, "word": " say", "probability": 0.935546875}, {"start": 1709.67, "end": 1710.27, "word": " several", "probability": 0.90283203125}, {"start": 1710.27, "end": 1711.21, "word": " homework", "probability": 0.88916015625}, {"start": 1711.21, "end": 1711.91, "word": " assignments.", "probability": 0.93896484375}, {"start": 1712.07, "end": 1712.19, "word": " Very", "probability": 0.82763671875}, {"start": 1712.19, "end": 1712.43, "word": " good.", "probability": 0.92236328125}, {"start": 1713.81, "end": 1714.33, "word": " Next", "probability": 0.9130859375}, {"start": 1714.33, "end": 1714.65, "word": " one.", "probability": 0.92822265625}], "temperature": 1.0}, {"id": 63, "seek": 174965, "start": 1722.95, "end": 1749.65, "text": " Clean and right. Just a minute. Okay, go on, go on. As what? Uh-huh. Pilots. Pilots. Archeologists. Archeologists. Okay.", "tokens": [18463, 293, 558, 13, 1449, 257, 3456, 13, 1033, 11, 352, 322, 11, 352, 322, 13, 1018, 437, 30, 4019, 12, 18710, 13, 18026, 1971, 13, 18026, 1971, 13, 1587, 1876, 12256, 13, 1587, 1876, 12256, 13, 1033, 13], "avg_logprob": -0.21640625707805156, "compression_ratio": 1.2736842105263158, "no_speech_prob": 0.0, "words": [{"start": 1722.95, "end": 1723.33, "word": " Clean", "probability": 0.64990234375}, {"start": 1723.33, "end": 1723.59, "word": " and", "probability": 0.9443359375}, {"start": 1723.59, "end": 1723.93, "word": " right.", "probability": 0.67724609375}, {"start": 1737.67, "end": 1738.33, "word": " Just", "probability": 0.77392578125}, {"start": 1738.33, "end": 1738.57, "word": " a", "probability": 0.99755859375}, {"start": 1738.57, "end": 1738.77, "word": " minute.", "probability": 0.93017578125}, {"start": 1739.25, "end": 1739.47, "word": " Okay,", "probability": 0.775390625}, {"start": 1739.59, "end": 1739.71, "word": " go", "probability": 0.94140625}, {"start": 1739.71, "end": 1739.87, "word": " on,", "probability": 0.95068359375}, {"start": 1739.93, "end": 1740.07, "word": " go", "probability": 0.95458984375}, {"start": 1740.07, "end": 1740.29, "word": " on.", "probability": 0.951171875}, {"start": 1740.55, "end": 1740.79, "word": " As", "probability": 0.912109375}, {"start": 1740.79, "end": 1741.15, "word": " what?", "probability": 0.9599609375}, {"start": 1743.53, "end": 1743.81, "word": " Uh", "probability": 0.300537109375}, {"start": 1743.81, "end": 1743.95, "word": "-huh.", "probability": 0.764892578125}, {"start": 1744.53, "end": 1745.19, "word": " Pilots.", "probability": 0.898193359375}, {"start": 1745.53, "end": 1746.19, "word": " Pilots.", "probability": 0.896484375}, {"start": 1746.81, "end": 1747.47, "word": " Archeologists.", "probability": 0.754150390625}, {"start": 1747.69, "end": 1748.35, "word": " Archeologists.", "probability": 0.9375}, {"start": 1749.17, "end": 1749.65, "word": " Okay.", "probability": 0.3583984375}], "temperature": 1.0}, {"id": 64, "seek": 177543, "start": 1756.67, "end": 1775.43, "text": " Without apostrophe. Now, refer to the first word. What do you think of this word, woman? Without S and read it. Is it singular or plural now? Okay, and you use the plural. You use the plural. So it should be what?", "tokens": [9129, 19484, 27194, 13, 823, 11, 2864, 281, 264, 700, 1349, 13, 708, 360, 291, 519, 295, 341, 1349, 11, 3059, 30, 9129, 318, 293, 1401, 309, 13, 1119, 309, 20010, 420, 25377, 586, 30, 1033, 11, 293, 291, 764, 264, 25377, 13, 509, 764, 264, 25377, 13, 407, 309, 820, 312, 437, 30], "avg_logprob": -0.21505681709809737, "compression_ratio": 1.445945945945946, "no_speech_prob": 0.0, "words": [{"start": 1756.67, "end": 1757.15, "word": " Without", "probability": 0.404296875}, {"start": 1757.15, "end": 1757.63, "word": " apostrophe.", "probability": 0.940185546875}, {"start": 1757.81, "end": 1757.93, "word": " Now,", "probability": 0.86474609375}, {"start": 1758.17, "end": 1758.37, "word": " refer", "probability": 0.9033203125}, {"start": 1758.37, "end": 1758.63, "word": " to", "probability": 0.974609375}, {"start": 1758.63, "end": 1758.81, "word": " the", "probability": 0.91552734375}, {"start": 1758.81, "end": 1759.11, "word": " first", "probability": 0.88525390625}, {"start": 1759.11, "end": 1759.43, "word": " word.", "probability": 0.912109375}, {"start": 1759.49, "end": 1759.61, "word": " What", "probability": 0.87255859375}, {"start": 1759.61, "end": 1759.71, "word": " do", "probability": 0.953125}, {"start": 1759.71, "end": 1759.81, "word": " you", "probability": 0.96728515625}, {"start": 1759.81, "end": 1760.03, "word": " think", "probability": 0.9072265625}, {"start": 1760.03, "end": 1760.17, "word": " of", "probability": 0.94580078125}, {"start": 1760.17, "end": 1760.35, "word": " this", "probability": 0.9345703125}, {"start": 1760.35, "end": 1760.59, "word": " word,", "probability": 0.916015625}, {"start": 1760.63, "end": 1760.87, "word": " woman?", "probability": 0.71875}, {"start": 1764.49, "end": 1764.97, "word": " Without", "probability": 0.76611328125}, {"start": 1764.97, "end": 1765.29, "word": " S", "probability": 0.388427734375}, {"start": 1765.29, "end": 1765.53, "word": " and", "probability": 0.77490234375}, {"start": 1765.53, "end": 1765.81, "word": " read", "probability": 0.9580078125}, {"start": 1765.81, "end": 1766.05, "word": " it.", "probability": 0.95458984375}, {"start": 1767.25, "end": 1767.73, "word": " Is", "probability": 0.92626953125}, {"start": 1767.73, "end": 1768.03, "word": " it", "probability": 0.94970703125}, {"start": 1768.03, "end": 1768.63, "word": " singular", "probability": 0.95947265625}, {"start": 1768.63, "end": 1768.97, "word": " or", "probability": 0.96142578125}, {"start": 1768.97, "end": 1769.35, "word": " plural", "probability": 0.9736328125}, {"start": 1769.35, "end": 1769.73, "word": " now?", "probability": 0.89501953125}, {"start": 1771.07, "end": 1771.55, "word": " Okay,", "probability": 0.63720703125}, {"start": 1771.79, "end": 1772.05, "word": " and", "probability": 0.86083984375}, {"start": 1772.05, "end": 1772.23, "word": " you", "probability": 0.9404296875}, {"start": 1772.23, "end": 1772.49, "word": " use", "probability": 0.6259765625}, {"start": 1772.49, "end": 1772.65, "word": " the", "probability": 0.9013671875}, {"start": 1772.65, "end": 1772.99, "word": " plural.", "probability": 0.97216796875}, {"start": 1773.29, "end": 1773.39, "word": " You", "probability": 0.395751953125}, {"start": 1773.39, "end": 1773.67, "word": " use", "probability": 0.78857421875}, {"start": 1773.67, "end": 1773.83, "word": " the", "probability": 0.91259765625}, {"start": 1773.83, "end": 1774.13, "word": " plural.", "probability": 0.9765625}, {"start": 1774.31, "end": 1774.41, "word": " So", "probability": 0.92626953125}, {"start": 1774.41, "end": 1774.57, "word": " it", "probability": 0.642578125}, {"start": 1774.57, "end": 1774.89, "word": " should", "probability": 0.94482421875}, {"start": 1774.89, "end": 1775.11, "word": " be", "probability": 0.95263671875}, {"start": 1775.11, "end": 1775.43, "word": " what?", "probability": 0.89794921875}], "temperature": 1.0}, {"id": 65, "seek": 179329, "start": 1776.41, "end": 1793.29, "text": " Women. Women. No, Ki without S. You are right. We don't need the S on all cases. So we say women, right? Write it. Women. Women. Regular. Regular. Women. 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And next one. Respects, good, thank you. And finally, respects.", "tokens": [11065, 11, 1392, 11, 1309, 291, 13, 400, 958, 472, 13, 39079, 82, 11, 665, 11, 1309, 291, 13, 400, 2721, 11, 24126, 13], "avg_logprob": -0.19875, "compression_ratio": 1.1733333333333333, "no_speech_prob": 0.0, "words": [{"start": 1801.73, "end": 1801.95, "word": " Women,", "probability": 0.43212890625}, {"start": 1802.45, "end": 1802.67, "word": " okay,", "probability": 0.904296875}, {"start": 1802.85, "end": 1803.05, "word": " thank", "probability": 0.8583984375}, {"start": 1803.05, "end": 1803.29, "word": " you.", "probability": 0.96826171875}, {"start": 1804.39, "end": 1804.77, "word": " And", "probability": 0.93896484375}, {"start": 1804.77, "end": 1806.25, "word": " next", "probability": 0.85009765625}, {"start": 1806.25, "end": 1806.63, "word": " one.", "probability": 0.943359375}, {"start": 1821.85, "end": 1822.69, "word": " Respects,", "probability": 0.49658203125}, {"start": 1822.75, "end": 1822.97, "word": " good,", "probability": 0.88671875}, {"start": 1823.41, "end": 1823.71, "word": " thank", "probability": 0.8603515625}, {"start": 1823.71, "end": 1823.95, "word": " you.", "probability": 0.96435546875}, {"start": 1824.37, "end": 1824.89, "word": " And", "probability": 0.9560546875}, {"start": 1824.89, "end": 1825.47, "word": " finally,", "probability": 0.8720703125}, {"start": 1827.19, "end": 1827.63, "word": " respects.", "probability": 0.79638671875}], "temperature": 1.0}, {"id": 67, "seek": 187916, "start": 1851.76, "end": 1879.16, "text": " Yeah, what are you doing? Read aloud, read aloud. Now why did you add S? How to?", "tokens": [865, 11, 437, 366, 291, 884, 30, 17604, 43888, 11, 1401, 43888, 13, 823, 983, 630, 291, 909, 318, 30, 1012, 281, 30], "avg_logprob": -0.2189127573122581, "compression_ratio": 1.0657894736842106, "no_speech_prob": 0.0, "words": [{"start": 1851.76, "end": 1852.02, "word": " Yeah,", "probability": 0.634765625}, {"start": 1852.08, "end": 1852.24, "word": " what", "probability": 0.93896484375}, {"start": 1852.24, "end": 1852.4, "word": " are", "probability": 0.91845703125}, {"start": 1852.4, "end": 1852.52, "word": " you", "probability": 0.96630859375}, {"start": 1852.52, "end": 1852.8, "word": " doing?", "probability": 0.9697265625}, {"start": 1852.9, "end": 1853.06, "word": " Read", "probability": 0.87255859375}, {"start": 1853.06, "end": 1853.36, "word": " aloud,", "probability": 0.98193359375}, {"start": 1853.46, "end": 1853.64, "word": " read", "probability": 0.9638671875}, {"start": 1853.64, "end": 1854.06, "word": " aloud.", "probability": 0.97265625}, {"start": 1860.0, "end": 1860.52, "word": " Now", "probability": 0.314453125}, {"start": 1860.52, "end": 1876.38, "word": " why", "probability": 0.55859375}, {"start": 1876.38, "end": 1876.56, "word": " did", "probability": 0.962890625}, {"start": 1876.56, "end": 1876.76, "word": " you", "probability": 0.96484375}, {"start": 1876.76, "end": 1877.08, "word": " add", "probability": 0.89501953125}, {"start": 1877.08, "end": 1877.46, "word": " S?", "probability": 0.48828125}, {"start": 1878.46, "end": 1878.86, "word": " How", "probability": 0.943359375}, {"start": 1878.86, "end": 1879.16, "word": " to?", "probability": 0.970703125}], "temperature": 1.0}, {"id": 68, "seek": 190638, "start": 1879.96, "end": 1906.38, "text": " How to spend? Okay. How to spend? His or her? Okay. Himself or herself? How does it depend? On himself or herself? Yeah, you say what. Just let's finish. Change that. Him or her? Himself or herself? Yeah.", "tokens": [1012, 281, 3496, 30, 1033, 13, 1012, 281, 3496, 30, 2812, 420, 720, 30, 1033, 13, 26821, 420, 7530, 30, 1012, 775, 309, 5672, 30, 1282, 3647, 420, 7530, 30, 865, 11, 291, 584, 437, 13, 1449, 718, 311, 2413, 13, 15060, 300, 13, 5920, 420, 720, 30, 26821, 420, 7530, 30, 865, 13], "avg_logprob": -0.29147727272727275, "compression_ratio": 1.6942148760330578, "no_speech_prob": 0.0, "words": [{"start": 1879.96, "end": 1880.6, "word": " How", "probability": 0.382080078125}, {"start": 1880.6, "end": 1881.26, "word": " to", "probability": 0.94921875}, {"start": 1881.26, "end": 1882.74, "word": " spend?", "probability": 0.57373046875}, {"start": 1883.22, "end": 1883.34, "word": " Okay.", "probability": 0.2183837890625}, {"start": 1883.76, "end": 1884.08, "word": " How", "probability": 0.72509765625}, {"start": 1884.08, "end": 1884.3, "word": " to", "probability": 0.96875}, {"start": 1884.3, "end": 1884.74, "word": " spend?", "probability": 0.8896484375}, {"start": 1885.84, "end": 1886.26, "word": " His", "probability": 0.87451171875}, {"start": 1886.26, "end": 1886.6, "word": " or", "probability": 0.888671875}, {"start": 1886.6, "end": 1887.0, "word": " her?", "probability": 0.849609375}, {"start": 1887.3, "end": 1887.56, "word": " Okay.", "probability": 0.52685546875}, {"start": 1888.12, "end": 1888.76, "word": " Himself", "probability": 0.462890625}, {"start": 1888.76, "end": 1890.6, "word": " or", "probability": 0.95458984375}, {"start": 1890.6, "end": 1890.96, "word": " herself?", "probability": 0.84912109375}, {"start": 1892.56, "end": 1892.86, "word": " How", "probability": 0.783203125}, {"start": 1892.86, "end": 1893.1, "word": " does", "probability": 0.63330078125}, {"start": 1893.1, "end": 1893.3, "word": " it", "probability": 0.91748046875}, {"start": 1893.3, "end": 1893.76, "word": " depend?", "probability": 0.8720703125}, {"start": 1893.88, "end": 1894.06, "word": " On", "probability": 0.78564453125}, {"start": 1894.06, "end": 1894.48, "word": " himself", "probability": 0.85595703125}, {"start": 1894.48, "end": 1894.96, "word": " or", "probability": 0.95458984375}, {"start": 1894.96, "end": 1895.32, "word": " herself?", "probability": 0.873046875}, {"start": 1896.64, "end": 1897.36, "word": " Yeah,", "probability": 0.61767578125}, {"start": 1897.48, "end": 1897.66, "word": " you", "probability": 0.91845703125}, {"start": 1897.66, "end": 1897.9, "word": " say", "probability": 0.8251953125}, {"start": 1897.9, "end": 1898.1, "word": " what.", "probability": 0.759765625}, {"start": 1898.2, "end": 1898.38, "word": " Just", "probability": 0.69384765625}, {"start": 1898.38, "end": 1898.68, "word": " let's", "probability": 0.798828125}, {"start": 1898.68, "end": 1899.2, "word": " finish.", "probability": 0.93505859375}, {"start": 1899.76, "end": 1900.48, "word": " Change", "probability": 0.79638671875}, {"start": 1900.48, "end": 1900.74, "word": " that.", "probability": 0.9140625}, {"start": 1900.84, "end": 1901.08, "word": " Him", "probability": 0.9814453125}, {"start": 1901.08, "end": 1901.32, "word": " or", "probability": 0.962890625}, {"start": 1901.32, "end": 1901.58, "word": " her?", "probability": 0.8779296875}, {"start": 1901.86, "end": 1902.38, "word": " Himself", "probability": 0.78564453125}, {"start": 1902.38, "end": 1903.2, "word": " or", "probability": 0.9453125}, {"start": 1903.2, "end": 1903.6, "word": " herself?", "probability": 0.88232421875}, {"start": 1905.66, "end": 1906.38, "word": " Yeah.", "probability": 0.76171875}], "temperature": 1.0}, {"id": 69, "seek": 192599, "start": 1909.97, "end": 1925.99, "text": " Him? Self? Yeah, who wanted to say something? Who was, yeah? Okay, good, good. Come, come, come. Complete it. Children? Okay, children need?", "tokens": [5920, 30, 16348, 30, 865, 11, 567, 1415, 281, 584, 746, 30, 2102, 390, 11, 1338, 30, 1033, 11, 665, 11, 665, 13, 2492, 11, 808, 11, 808, 13, 34687, 309, 13, 13354, 30, 1033, 11, 2227, 643, 30], "avg_logprob": -0.3591796919703484, "compression_ratio": 1.2702702702702702, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1909.97, "end": 1910.49, "word": " Him?", "probability": 0.56640625}, {"start": 1910.97, "end": 1911.49, "word": " Self?", "probability": 0.568359375}, {"start": 1913.11, "end": 1913.37, "word": " Yeah,", "probability": 0.64794921875}, {"start": 1913.49, "end": 1913.63, "word": " who", "probability": 0.8955078125}, {"start": 1913.63, "end": 1913.93, "word": " wanted", "probability": 0.876953125}, {"start": 1913.93, "end": 1914.17, "word": " to", "probability": 0.974609375}, {"start": 1914.17, "end": 1914.33, "word": " say", "probability": 0.95458984375}, {"start": 1914.33, "end": 1914.83, "word": " something?", "probability": 0.86181640625}, {"start": 1915.03, "end": 1915.09, "word": " Who", "probability": 0.52099609375}, {"start": 1915.09, "end": 1915.41, "word": " was,", "probability": 0.93408203125}, {"start": 1915.67, "end": 1915.67, "word": " yeah?", "probability": 0.9296875}, {"start": 1917.23, "end": 1917.75, "word": " Okay,", "probability": 0.27783203125}, {"start": 1918.01, "end": 1918.19, "word": " good,", "probability": 0.86767578125}, {"start": 1918.33, "end": 1918.55, "word": " good.", "probability": 0.919921875}, {"start": 1918.61, "end": 1918.85, "word": " Come,", "probability": 0.875}, {"start": 1919.01, "end": 1919.31, "word": " come,", "probability": 0.90185546875}, {"start": 1919.49, "end": 1920.13, "word": " come.", "probability": 0.89501953125}, {"start": 1920.33, "end": 1920.69, "word": " Complete", "probability": 0.40673828125}, {"start": 1920.69, "end": 1921.07, "word": " it.", "probability": 0.732421875}, {"start": 1921.93, "end": 1922.37, "word": " Children?", "probability": 0.90380859375}, {"start": 1924.33, "end": 1924.85, "word": " Okay,", "probability": 0.77978515625}, {"start": 1925.05, "end": 1925.43, "word": " children", "probability": 0.8388671875}, {"start": 1925.43, "end": 1925.99, "word": " need?", "probability": 0.9296875}], "temperature": 1.0}, {"id": 70, "seek": 195282, "start": 1931.02, "end": 1952.82, "text": " Okay, write it, write it. No, no, no. Keep the first answer. Okay, just a minute. Did you finish? Did you correct it as done before? So clean it all, the last one, and do it again. So we can say children need. Children need, good.", "tokens": [1033, 11, 2464, 309, 11, 2464, 309, 13, 883, 11, 572, 11, 572, 13, 5527, 264, 700, 1867, 13, 1033, 11, 445, 257, 3456, 13, 2589, 291, 2413, 30, 2589, 291, 3006, 309, 382, 1096, 949, 30, 407, 2541, 309, 439, 11, 264, 1036, 472, 11, 293, 360, 309, 797, 13, 407, 321, 393, 584, 2227, 643, 13, 13354, 643, 11, 665, 13], "avg_logprob": -0.261474609375, "compression_ratio": 1.4713375796178343, "no_speech_prob": 6.556510925292969e-07, "words": [{"start": 1931.02, "end": 1931.5, "word": " Okay,", "probability": 0.10772705078125}, {"start": 1933.98, "end": 1934.26, "word": " write", "probability": 0.822265625}, {"start": 1934.26, "end": 1934.46, "word": " it,", "probability": 0.95166015625}, {"start": 1934.54, "end": 1934.76, "word": " write", "probability": 0.908203125}, {"start": 1934.76, "end": 1935.0, "word": " it.", "probability": 0.95458984375}, {"start": 1935.04, "end": 1935.18, "word": " No,", "probability": 0.8173828125}, {"start": 1935.26, "end": 1935.36, "word": " no,", "probability": 0.90869140625}, {"start": 1935.42, "end": 1935.54, "word": " no.", "probability": 0.8837890625}, {"start": 1935.68, "end": 1935.92, "word": " Keep", "probability": 0.8720703125}, {"start": 1935.92, "end": 1936.1, "word": " the", "probability": 0.85498046875}, {"start": 1936.1, "end": 1936.5, "word": " first", "probability": 0.88623046875}, {"start": 1936.5, "end": 1937.08, "word": " answer.", "probability": 0.95703125}, {"start": 1937.96, "end": 1938.42, "word": " Okay,", "probability": 0.44580078125}, {"start": 1938.54, "end": 1938.72, "word": " just", "probability": 0.861328125}, {"start": 1938.72, "end": 1938.92, "word": " a", "probability": 0.99658203125}, {"start": 1938.92, "end": 1939.02, "word": " minute.", "probability": 0.923828125}, {"start": 1939.12, "end": 1939.24, "word": " Did", "probability": 0.9521484375}, {"start": 1939.24, "end": 1939.38, "word": " you", "probability": 0.970703125}, {"start": 1939.38, "end": 1939.76, "word": " finish?", "probability": 0.79248046875}, {"start": 1940.08, "end": 1940.28, "word": " Did", "probability": 0.93505859375}, {"start": 1940.28, "end": 1940.44, "word": " you", "probability": 0.97021484375}, {"start": 1940.44, "end": 1941.24, "word": " correct", "probability": 0.5859375}, {"start": 1941.24, "end": 1941.7, "word": " it", "probability": 0.89990234375}, {"start": 1941.7, "end": 1942.48, "word": " as", "probability": 0.83251953125}, {"start": 1942.48, "end": 1942.72, "word": " done", "probability": 0.833984375}, {"start": 1942.72, "end": 1943.14, "word": " before?", "probability": 0.8642578125}, {"start": 1943.6, "end": 1943.9, "word": " So", "probability": 0.90087890625}, {"start": 1943.9, "end": 1944.26, "word": " clean", "probability": 0.62939453125}, {"start": 1944.26, "end": 1944.42, "word": " it", "probability": 0.93310546875}, {"start": 1944.42, "end": 1944.76, "word": " all,", "probability": 0.92236328125}, {"start": 1944.9, "end": 1945.26, "word": " the", "probability": 0.88916015625}, {"start": 1945.26, "end": 1945.58, "word": " last", "probability": 0.87109375}, {"start": 1945.58, "end": 1945.9, "word": " one,", "probability": 0.9345703125}, {"start": 1946.06, "end": 1946.28, "word": " and", "probability": 0.939453125}, {"start": 1946.28, "end": 1946.4, "word": " do", "probability": 0.9580078125}, {"start": 1946.4, "end": 1946.58, "word": " it", "probability": 0.95458984375}, {"start": 1946.58, "end": 1946.94, "word": " again.", "probability": 0.962890625}, {"start": 1947.5, "end": 1947.72, "word": " So", "probability": 0.93017578125}, {"start": 1947.72, "end": 1947.94, "word": " we", "probability": 0.86962890625}, {"start": 1947.94, "end": 1948.16, "word": " can", "probability": 0.947265625}, {"start": 1948.16, "end": 1948.52, "word": " say", "probability": 0.94921875}, {"start": 1948.52, "end": 1949.74, "word": " children", "probability": 0.486328125}, {"start": 1949.74, "end": 1950.26, "word": " need.", "probability": 0.92626953125}, {"start": 1951.6, "end": 1952.08, "word": " Children", "probability": 0.908203125}, {"start": 1952.08, "end": 1952.52, "word": " need,", "probability": 0.923828125}, {"start": 1952.6, "end": 1952.82, "word": " good.", "probability": 0.93115234375}], "temperature": 1.0}, {"id": 71, "seek": 197525, "start": 1959.49, "end": 1975.25, "text": " Okay, other people? Very good. This is also a good answer. Thank you very much.", "tokens": [1033, 11, 661, 561, 30, 4372, 665, 13, 639, 307, 611, 257, 665, 1867, 13, 1044, 291, 588, 709, 13], "avg_logprob": -0.26562500567663283, "compression_ratio": 1.0126582278481013, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1959.49, "end": 1959.69, "word": " Okay,", "probability": 0.292724609375}, {"start": 1959.95, "end": 1960.25, "word": " other", "probability": 0.8369140625}, {"start": 1960.25, "end": 1960.83, "word": " people?", "probability": 0.97705078125}, {"start": 1964.21, "end": 1964.81, "word": " Very", "probability": 0.2281494140625}, {"start": 1964.81, "end": 1968.37, "word": " good.", "probability": 0.91552734375}, {"start": 1969.17, "end": 1969.47, "word": " This", "probability": 0.828125}, {"start": 1969.47, "end": 1969.65, "word": " is", "probability": 0.95166015625}, {"start": 1969.65, "end": 1969.97, "word": " also", "probability": 0.87744140625}, {"start": 1969.97, "end": 1970.13, "word": " a", "probability": 0.9892578125}, {"start": 1970.13, "end": 1970.29, "word": " good", "probability": 0.9208984375}, {"start": 1970.29, "end": 1970.79, "word": " answer.", "probability": 0.96337890625}, {"start": 1974.07, "end": 1974.67, "word": " Thank", "probability": 0.87353515625}, {"start": 1974.67, "end": 1974.79, "word": " you", "probability": 0.958984375}, {"start": 1974.79, "end": 1974.97, "word": " very", "probability": 0.853515625}, {"start": 1974.97, "end": 1975.25, "word": " much.", "probability": 0.91796875}], "temperature": 1.0}], "language": "en", "language_probability": 1.0, "duration": 1976.66825, "duration_after_vad": 1769.129374999995} \ No newline at end of file diff --git a/PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/W_Qo-nUZcl8_raw.srt b/PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/W_Qo-nUZcl8_raw.srt new file mode 100644 index 0000000000000000000000000000000000000000..8116aad2dcadd2323571c8d584bd5279aa43a379 --- /dev/null +++ b/PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/W_Qo-nUZcl8_raw.srt @@ -0,0 +1,1712 @@ +1 +00:00:21,040 --> 00:00:23,180 +Good morning to you all. Good morning. + +2 +00:00:23,560 --> 00:00:25,560 +Assalamualaikum. Assalamualaikum. How are you? + +3 +00:00:25,800 --> 00:00:29,260 +Fine. Okay, let's start a new week with a smile. + +4 +00:00:30,220 --> 00:00:35,500 +Okay? Inshallah. Let's look at the exercise on the + +5 +00:00:35,500 --> 00:00:41,120 +blackboard. This is a dialogue between Mr. and + +6 +00:00:41,120 --> 00:00:44,340 +Mrs. Cox. Guess what you'd like to read, please. + +7 +00:00:45,600 --> 00:00:50,370 +Jacques would spot a used car. Did you hear? Did + +8 +00:00:50,370 --> 00:00:56,790 +you hear? Did you hear? Go on. Yes, I heard all + +9 +00:00:56,790 --> 00:01:01,330 +about his car. He paid next to nothing for it. + +10 +00:01:01,450 --> 00:01:04,930 +Thank you very much. Now listen. Now Mrs. Cox is + +11 +00:01:04,930 --> 00:01:09,230 +addressing what? Mr. Cox when she says did you + +12 +00:01:09,230 --> 00:01:13,470 +hear you is used as a personal pronoun when I say + +13 +00:01:13,470 --> 00:01:18,870 +Fatima Did you see did you read? Okay? Do you want + +14 +00:01:18,870 --> 00:01:21,330 +this is personal pronoun? You are talking to + +15 +00:01:21,330 --> 00:01:25,310 +Fatima to Ali to Abdullah and so on Okay. Now you + +16 +00:01:25,310 --> 00:01:32,980 +is a personal pronoun again Yes, I I Ah, refers + +17 +00:01:32,980 --> 00:01:40,200 +to? Yeah, Mr. Cox. Again, a personal pronoun. I + +18 +00:01:40,200 --> 00:01:44,100 +heard all about his car. He paid. He, who is he? + +19 +00:01:44,540 --> 00:01:49,180 +Jack. Okay, so it talks about a certain person. He + +20 +00:01:49,180 --> 00:01:53,740 +again is a personal pronoun. Yeah, nothing, he + +21 +00:01:53,740 --> 00:01:56,640 +paid next to nothing for it. What does it mean, he + +22 +00:01:56,640 --> 00:02:01,850 +paid next to nothing? He paid almost nothing. Very + +23 +00:02:01,850 --> 00:02:06,150 +good. Thank you. That's right. Now, he paid next + +24 +00:02:06,150 --> 00:02:09,630 +to nothing for it. It refers to what? To the car. + +25 +00:02:09,810 --> 00:02:13,650 +So, the pronouns, these pronouns, you, he, I, it, + +26 +00:02:13,790 --> 00:02:17,350 +they refer to what? They are personal pronouns. + +27 +00:02:17,670 --> 00:02:21,910 +They refer to specific things. Okay, specific + +28 +00:02:21,910 --> 00:02:27,530 +nouns. Now look, and now it doesn't run. Now it + +29 +00:02:27,530 --> 00:02:35,080 +doesn't run. Well, as they say, you get what you + +30 +00:02:35,080 --> 00:02:40,220 +pay for. Thank you. As they say, you get what you + +31 +00:02:40,220 --> 00:02:46,840 +pay for. They say a sound mind is in a sound body. + +32 +00:02:47,480 --> 00:02:51,600 +Who are they? People in general. Very good. Thank + +33 +00:02:51,600 --> 00:02:56,120 +you very much. Now, when I say, when I, when she + +34 +00:02:56,120 --> 00:03:00,460 +says right and sorry, as they say, you get what + +35 +00:03:00,460 --> 00:03:04,240 +you pay for. You get what you pay for. What does + +36 +00:03:04,240 --> 00:03:08,800 +this pronoun you refer to? People in general. Any + +37 +00:03:08,800 --> 00:03:14,450 +person. Thank you. And what you pay for? Also + +38 +00:03:14,450 --> 00:03:16,990 +people in general. Thank you very much. Go on. + +39 +00:03:17,550 --> 00:03:21,270 +That's certainly true. One gets what one pays for. + +40 +00:03:21,350 --> 00:03:25,250 +Very good. One gets what one pays for. One means + +41 +00:03:25,250 --> 00:03:29,290 +what? Any person. Okay. It means also you. Okay. + +42 +00:03:29,610 --> 00:03:34,220 +Now. I have two groups of pronouns. What did you + +43 +00:03:34,220 --> 00:03:37,440 +understand from this exercise? Yes, what can you + +44 +00:03:37,440 --> 00:03:40,000 +say? Personal pronouns and impersonal pronouns. + +45 +00:03:40,160 --> 00:03:43,880 +Personal pronouns refer to specific nouns, but + +46 +00:03:43,880 --> 00:03:47,680 +impersonal pronouns refer to people in general or + +47 +00:03:47,680 --> 00:03:51,020 +any person. Very good. Thank you very much. So + +48 +00:03:51,020 --> 00:03:53,640 +sometimes we use the pronouns, the personal + +49 +00:03:53,640 --> 00:03:56,860 +pronouns to refer to certain persons, certain + +50 +00:03:56,860 --> 00:04:00,700 +nouns, okay? And sometimes they mean people in + +51 +00:04:00,700 --> 00:04:08,960 +general, people in general. Now look, one should + +52 +00:04:08,960 --> 00:04:14,570 +always be polite. What does it mean? I should + +53 +00:04:14,570 --> 00:04:17,770 +always be polite. You should always be polite. She + +54 +00:04:17,770 --> 00:04:21,410 +should always be polite. Okay, we should always be + +55 +00:04:21,410 --> 00:04:25,250 +polite, okay? So this is what? People in general, + +56 +00:04:25,390 --> 00:04:28,310 +right? Thank you. Read the other one, please. How + +57 +00:04:28,310 --> 00:04:31,410 +does one get to fifth advanced from here? Okay, + +58 +00:04:31,570 --> 00:04:35,610 +how does one? One refers to what? Anyone, very + +59 +00:04:35,610 --> 00:04:38,830 +good. How does a person, how can a person, okay? + +60 +00:04:39,350 --> 00:04:43,030 +Anyone, thank you. Now, one means in these + +61 +00:04:43,030 --> 00:04:47,310 +examples what? Any person, anyone, people in + +62 +00:04:47,310 --> 00:04:53,210 +general. So, you should always be polite. You + +63 +00:04:53,210 --> 00:04:56,790 +should always be polite. Now, does you mean one? + +64 +00:04:58,530 --> 00:05:02,170 +Why not? What's the difference? Yes, it means, it + +65 +00:05:02,170 --> 00:05:06,170 +does. Okay, when I say one should always be + +66 +00:05:06,170 --> 00:05:10,510 +polite, it means any, all people. Okay, people in + +67 +00:05:10,510 --> 00:05:13,730 +general. When I say you should always, it has also + +68 +00:05:13,730 --> 00:05:17,390 +the same meaning. But you know, one is much more + +69 +00:05:17,390 --> 00:05:23,320 +formal than you, okay? Now, they are used in + +70 +00:05:23,320 --> 00:05:28,100 +everyday English. Now, I have two pronouns, one + +71 +00:05:28,100 --> 00:05:34,220 +and you. They refer to what? To people in general. + +72 +00:05:34,740 --> 00:05:38,270 +What's the difference between you and one? This + +73 +00:05:38,270 --> 00:05:43,090 +one is more formal. You is used in everyday + +74 +00:05:43,090 --> 00:05:46,810 +English, in spoken English. But they have almost + +75 +00:05:46,810 --> 00:05:51,370 +the same meaning. Now, we have a mistake here. + +76 +00:05:54,690 --> 00:05:58,350 +This should be capital, right? Yes. + +77 +00:06:05,010 --> 00:06:10,990 +Keep the capital. Okay. Now, read the example, + +78 +00:06:11,290 --> 00:06:11,530 +please. + +79 +00:06:14,790 --> 00:06:18,390 +Thank you. + +80 +00:06:19,050 --> 00:06:23,730 +They grow a lot of corn. They refers to what in + +81 +00:06:23,730 --> 00:06:24,470 +this example? + +82 +00:06:27,210 --> 00:06:31,850 +Refers to what? Who grows? Who does? Farmers. + +83 +00:06:32,350 --> 00:06:36,210 +Okay, farmers. That's right. Now, is it? They + +84 +00:06:36,210 --> 00:06:43,630 +grow. Does it refer to a group of people? Just a + +85 +00:06:43,630 --> 00:06:49,370 +minute. When I say farmers, farmers in general, it + +86 +00:06:49,370 --> 00:06:52,330 +is right. Farmers are a group of people. But are + +87 +00:06:52,330 --> 00:06:56,930 +they a specific group of people? No. So again, is + +88 +00:06:56,930 --> 00:07:00,690 +it a personal pronoun or an impersonal pronoun? + +89 +00:07:03,010 --> 00:07:07,770 +Fatima, okay. When I say Dua and Khadijah are + +90 +00:07:07,770 --> 00:07:12,290 +sitting here, they are my students. They are, they + +91 +00:07:12,290 --> 00:07:17,190 +are is they, okay I refer to two specific persons, + +92 +00:07:17,310 --> 00:07:20,990 +right? But when I say they grew a lot, they grew a + +93 +00:07:20,990 --> 00:07:24,490 +lot. This is in general, farmers in general, this + +94 +00:07:24,490 --> 00:07:29,250 +is impersonal pronoun. It means again what? It + +95 +00:07:29,250 --> 00:07:33,680 +means what? People in general. Thank you very + +96 +00:07:33,680 --> 00:07:39,700 +much. Again, it refers to an undefined group of + +97 +00:07:39,700 --> 00:07:43,000 +people, not specific. It doesn't refer to a + +98 +00:07:43,000 --> 00:07:46,160 +specific group of people. Now, they have not + +99 +00:07:46,160 --> 00:07:51,840 +stated antecedent. Often, the antecedent is + +100 +00:07:51,840 --> 00:07:56,370 +implied. You understand it from the context, okay? + +101 +00:07:56,710 --> 00:08:00,770 +When I say, they say, a sound mind, or they say, + +102 +00:08:00,850 --> 00:08:03,910 +an apple a day keeps the doctor away. Who says + +103 +00:08:03,910 --> 00:08:07,170 +that? Okay, the antecedent can be understood. + +104 +00:08:07,650 --> 00:08:09,050 +Doctors, for example. Good. + +105 +00:08:12,190 --> 00:08:16,790 +Now look at this exercise. Discuss the meaning of + +106 +00:08:16,790 --> 00:08:20,150 +the pronouns in Italics. Number one, who can read? + +107 +00:08:21,590 --> 00:08:26,050 +Murida. War requires special care. If you wash + +108 +00:08:26,050 --> 00:08:29,370 +wool in hot water, you will shrink. You shouldn't + +109 +00:08:29,370 --> 00:08:32,910 +throw a wool sweater into a washing machine with + +110 +00:08:32,910 --> 00:08:36,850 +your cottons. This pronoun refers to people in + +111 +00:08:36,850 --> 00:08:39,750 +general. Very good. So now, if you wash, you + +112 +00:08:39,750 --> 00:08:43,690 +shouldn't, okay? With your cottons, they refer to + +113 +00:08:43,690 --> 00:08:46,670 +people in general. That's right. Thank you. Nada? + +114 +00:08:47,870 --> 00:08:50,850 +Alice, I told you not to wash your sweater in hot + +115 +00:08:50,850 --> 00:08:51,170 +water. + +116 +00:08:56,700 --> 00:09:01,800 +Very good. So you and you refer to what? To Alex. + +117 +00:09:01,900 --> 00:09:04,720 +So they are personally pronounced. Thank you. Yes, + +118 +00:09:04,760 --> 00:09:09,060 +please. Next one. Generosity is its own reward. + +119 +00:09:09,380 --> 00:09:11,860 +You always get back more than you get. It's + +120 +00:09:11,860 --> 00:09:15,800 +impersonal. Impersonal. That's right. Good. Thank + +121 +00:09:15,800 --> 00:09:16,080 +you. + +122 +00:09:23,350 --> 00:09:28,770 +Okay, good. So is it a personal or impersonal + +123 +00:09:28,770 --> 00:09:32,070 +pronoun? Personal pronoun. Thank you. Good. Yes, + +124 +00:09:32,170 --> 00:09:36,670 +please. Environmental problems are getting worse + +125 +00:09:36,670 --> 00:09:41,340 +all the time. They say that ozone Ozone. Ozone + +126 +00:09:41,340 --> 00:09:45,660 +layer. Ozone layer is being depleted more and more + +127 +00:09:45,660 --> 00:09:52,160 +every day. Okay, thank you. Good. To people in + +128 +00:09:52,160 --> 00:09:57,340 +general or to scientists. Thank you. Next one. + +129 +00:09:58,780 --> 00:10:03,570 +Yes, please. Memory selective. Often you remember + +130 +00:10:03,570 --> 00:10:06,290 +only what you want to remember. If you ask two + +131 +00:10:06,290 --> 00:10:08,790 +people to tell you about an experience they + +132 +00:10:08,790 --> 00:10:12,690 +shared, they might tell you two different stories, + +133 +00:10:13,110 --> 00:10:17,150 +people in general. Very good. You refer to people + +134 +00:10:17,150 --> 00:10:21,130 +in general. Thank you. Next one. Yes, please. I + +135 +00:10:21,130 --> 00:10:24,530 +would have loved to have gone to the concert last + +136 +00:10:24,530 --> 00:10:31,150 +night. They played Beethoven's seventh symphony. I + +137 +00:10:31,150 --> 00:10:35,140 +heard it was wonderful piece. Persons, the + +138 +00:10:35,140 --> 00:10:39,080 +musicians for example, the orchestra, people who + +139 +00:10:39,080 --> 00:10:42,080 +play the music. That's right. Thank you. Yes, + +140 +00:10:42,180 --> 00:10:45,580 +please. I've grown to dislike airplane travel. + +141 +00:10:46,080 --> 00:10:50,140 +They never give you enough room for your leg. And + +142 +00:10:50,140 --> 00:10:54,300 +if the person in front of you butts his seat back, + +143 +00:10:55,120 --> 00:10:59,200 +You can barely move. You can't enough reach down + +144 +00:10:59,200 --> 00:11:03,120 +to pick up something from the floor. They're an + +145 +00:11:03,120 --> 00:11:06,260 +airline company. Airline company. So is it a + +146 +00:11:06,260 --> 00:11:09,580 +personal pronoun? Yes. Is it a personal or + +147 +00:11:09,580 --> 00:11:14,320 +impersonal? Impersonal. Now again, they never give + +148 +00:11:14,320 --> 00:11:19,620 +you. It is understood from the context, okay? You + +149 +00:11:19,620 --> 00:11:22,560 +understand it from the context. Thank you very + +150 +00:11:22,560 --> 00:11:26,310 +much. Now, check your answers. Okay. Airline + +151 +00:11:26,310 --> 00:11:29,190 +company and the other one, people in general. + +152 +00:11:30,610 --> 00:11:35,410 +Again, look. Let's repeat it. They never give you + +153 +00:11:35,410 --> 00:11:38,650 +enough room for your legs. Your legs refers to + +154 +00:11:38,650 --> 00:11:43,170 +what? People in general. Okay. They refers to the + +155 +00:11:43,170 --> 00:11:49,050 +airline company. They never give you. And you can + +156 +00:11:49,050 --> 00:11:52,330 +barely move. You cannot even. This refers to what? + +157 +00:11:52,750 --> 00:11:56,420 +People in general. Check your answers. + +158 +00:12:22,900 --> 00:12:25,360 +Okay, you can complete that at home. You have the + +159 +00:12:25,360 --> 00:12:29,040 +answers on your webpage. Now look. + +160 +00:12:34,900 --> 00:12:42,220 +This is what? A pen. And this is another pen. This + +161 +00:12:42,220 --> 00:12:46,760 +is another pen. Okay? This is a pen and this is + +162 +00:12:46,760 --> 00:12:51,960 +another pen. Okay? I have a pen. And I have + +163 +00:12:52,300 --> 00:13:01,160 +another okay I have another now look where is the + +164 +00:13:01,160 --> 00:13:06,400 +other pen where is the other pen do you have other + +165 +00:13:06,400 --> 00:13:11,480 +pens where are the others other others the others + +166 +00:13:11,480 --> 00:13:17,800 +another okay how can we use them if you look if + +167 +00:13:17,800 --> 00:13:23,130 +you If you notice, we say, I have a pen. This is + +168 +00:13:23,130 --> 00:13:27,410 +another pen. Another pen. Another pen, look, + +169 +00:13:27,950 --> 00:13:33,090 +another is followed by what? Okay, good. By a + +170 +00:13:33,090 --> 00:13:35,650 +noun. Thank you very much. This is another noun. + +171 +00:13:36,390 --> 00:13:42,340 +So, I have two pens. I need another. I need + +172 +00:13:42,340 --> 00:13:46,720 +another. Another what? Another pen. Is it followed + +173 +00:13:46,720 --> 00:13:50,380 +by a noun? No. So sometimes it is followed by a + +174 +00:13:50,380 --> 00:13:54,060 +noun, sometimes it is not followed by a noun. When + +175 +00:13:54,060 --> 00:13:56,880 +it is followed by a noun, I say another book is, + +176 +00:13:56,960 --> 00:14:01,120 +for example, it is what? Adjective. Okay. But when + +177 +00:14:01,120 --> 00:14:04,560 +it is not followed, when it stands alone, it is + +178 +00:14:04,560 --> 00:14:10,120 +what? A pronoun. It is a pronoun. Now, look, I + +179 +00:14:10,120 --> 00:14:15,940 +have two forms singular and plural I say another + +180 +00:14:15,940 --> 00:14:21,880 +book the other book okay the other box it can be + +181 +00:14:21,880 --> 00:14:25,020 +used as you see for singular and for plural of + +182 +00:14:25,020 --> 00:14:28,810 +course you know The plural here is used with what? + +183 +00:14:29,210 --> 00:14:33,650 +With the noun. Not with the adjective. But here it + +184 +00:14:33,650 --> 00:14:36,550 +is the pronoun. The pronoun accepts the S. I say + +185 +00:14:36,550 --> 00:14:41,010 +other and I say what? The others. I say the + +186 +00:14:41,010 --> 00:14:47,740 +others. Now, forms of other are used as adjectives + +187 +00:14:47,740 --> 00:14:51,980 +or pronouns. Another is always singular. Look, + +188 +00:14:52,280 --> 00:14:57,880 +another is always singular. It means, I don't add + +189 +00:14:57,880 --> 00:15:00,920 +S to another. I want another pen. + +190 +00:15:04,500 --> 00:15:10,800 +Do you have another? And so on. A final S is + +191 +00:15:10,800 --> 00:15:15,850 +usually used only for a plural pronoun, others. We + +192 +00:15:15,850 --> 00:15:18,710 +use it with what? With others. Now let's look at + +193 +00:15:18,710 --> 00:15:23,430 +some examples and have more about this one. Yeah, + +194 +00:15:23,550 --> 00:15:25,790 +could you read the introduction please? The + +195 +00:15:25,790 --> 00:15:28,430 +students in the class come from many countries. + +196 +00:15:28,970 --> 00:15:32,310 +One of the students is from Mexico. Another + +197 +00:15:32,310 --> 00:15:36,250 +student is from Iraq. Another is from Japan. Other + +198 +00:15:36,250 --> 00:15:39,750 +students are from Brazil and others are from + +199 +00:15:39,750 --> 00:15:42,860 +Algeria. Thank you very much. Now look, I'm + +200 +00:15:42,860 --> 00:15:46,640 +looking at my students. One student is having a + +201 +00:15:46,640 --> 00:15:51,340 +black bag. Another is having a white bag. Another + +202 +00:15:51,340 --> 00:15:58,160 +is having a red bag. The others don't have bags. + +203 +00:15:58,860 --> 00:16:04,110 +Look, the others. don't have bags or others don't + +204 +00:16:04,110 --> 00:16:11,490 +have bags okay I say one again another is a having + +205 +00:16:11,490 --> 00:16:18,630 +another is having others are having white bags the + +206 +00:16:18,630 --> 00:16:22,150 +others are not having bags or I cannot see the + +207 +00:16:22,150 --> 00:16:26,050 +bags of the others now I use different pronouns + +208 +00:16:26,050 --> 00:16:31,510 +here look Another student is from Iraq. Another + +209 +00:16:31,510 --> 00:16:36,610 +is. Now, another means what? One more additional. + +210 +00:16:36,970 --> 00:16:41,650 +When I say she has one student is having a blue + +211 +00:16:41,650 --> 00:16:46,790 +bag. Another is having a white bag. Another, it + +212 +00:16:46,790 --> 00:16:51,130 +means what? One more in addition to what was + +213 +00:16:51,130 --> 00:16:53,970 +mentioned. Now, when I say + +214 +00:16:56,750 --> 00:17:02,510 +Okay. When I say others are from Algeria. Others + +215 +00:17:02,510 --> 00:17:07,030 +are from Algeria. Others means what? Now when I + +216 +00:17:07,030 --> 00:17:12,070 +say one student is having a blue bag, another is + +217 +00:17:12,070 --> 00:17:16,530 +having a white bag. Others. Others means what? + +218 +00:17:16,690 --> 00:17:20,490 +Several more. Several more. Another group of + +219 +00:17:20,490 --> 00:17:24,690 +students are having, for example, green bags. The + +220 +00:17:24,690 --> 00:17:30,370 +others. The others. The others means what? The + +221 +00:17:30,370 --> 00:17:34,030 +ones remained, okay? The last of the group, the + +222 +00:17:34,030 --> 00:17:39,970 +others. Okay? Again, we say another, one more in + +223 +00:17:39,970 --> 00:17:43,550 +addition to what was mentioned. Others means what? + +224 +00:17:44,210 --> 00:17:48,870 +Several more. Okay? One student is looking at the + +225 +00:17:48,870 --> 00:17:53,490 +book. Another student is writing. Others are + +226 +00:17:53,490 --> 00:18:00,160 +listening. The others are Okay, doing or writing + +227 +00:18:00,160 --> 00:18:04,480 +the exercise and so on. So now we use what? + +228 +00:18:04,820 --> 00:18:09,300 +Others, other, others and the others. They have + +229 +00:18:09,300 --> 00:18:13,420 +different meanings as you see. Now let's use them + +230 +00:18:13,420 --> 00:18:18,620 +together. Let's make examples using these pronouns + +231 +00:18:18,620 --> 00:18:23,620 +and adjectives. I have a pen. I want another. Can + +232 +00:18:23,620 --> 00:18:28,170 +you give me your pen? I have a pen. Give me your + +233 +00:18:28,170 --> 00:18:33,010 +pen. Not this, the other. Not this, the other. The + +234 +00:18:33,010 --> 00:18:37,590 +other. What does the other mean? The other means, + +235 +00:18:37,610 --> 00:18:40,330 +thank you very much. The other means the one + +236 +00:18:40,330 --> 00:18:45,430 +remained. The one remained. Okay? So, I have two + +237 +00:18:45,430 --> 00:18:50,350 +pens. I have two pens. I want another. I want + +238 +00:18:50,350 --> 00:18:53,910 +another. Okay? I want another. Can you give me + +239 +00:18:53,910 --> 00:18:58,650 +your pen? No, not this one, the other. The other + +240 +00:18:58,650 --> 00:19:05,410 +means? Okay, thank you. Now I have three pens. I + +241 +00:19:05,410 --> 00:19:08,830 +have three pens. Let's look at these pens, okay? + +242 +00:19:09,890 --> 00:19:13,250 +One, they are all having the same color, okay? + +243 +00:19:14,450 --> 00:19:22,710 +Anyhow, yeah. Give it to me, please. Yes, give me + +244 +00:19:22,710 --> 00:19:24,590 +the black one. Thank you. + +245 +00:19:29,980 --> 00:19:35,180 +Thank you. Now let's talk about these pencils. One + +246 +00:19:35,180 --> 00:19:42,600 +pencil is red. Another is black. + +247 +00:19:43,480 --> 00:19:46,200 +Others are blue. + +248 +00:19:49,480 --> 00:19:56,980 +The other is dark blue. Let's repeat. One is red. + +249 +00:19:59,090 --> 00:20:04,490 +Another means one more. Very good. Is what? Black. + +250 +00:20:05,170 --> 00:20:11,530 +Others, several more. Others, several more. Are + +251 +00:20:11,530 --> 00:20:17,770 +blue. The other, the last one of the group is dark + +252 +00:20:17,770 --> 00:20:22,190 +blue. The other. Can you give me some examples + +253 +00:20:22,190 --> 00:20:24,570 +like that? Think of an example. Thank you. Take + +254 +00:20:24,570 --> 00:20:25,050 +your pens. + +255 +00:20:28,210 --> 00:20:32,970 +Yeah. Can you think of an example? Yeah. I have + +256 +00:20:32,970 --> 00:20:39,250 +two hands. Very good. Very good. This is my right + +257 +00:20:39,250 --> 00:20:42,550 +hand. The other is my left hand. Very good. Thank + +258 +00:20:42,550 --> 00:20:46,470 +you very much. This is my right hand. The other is + +259 +00:20:46,470 --> 00:20:49,970 +my left hand. Thank you. This is a good example. + +260 +00:20:50,470 --> 00:20:52,110 +Yeah. Can you give me another example? + +261 +00:21:00,120 --> 00:21:05,740 +How many brothers have you got? Three? Okay. One + +262 +00:21:05,740 --> 00:21:08,280 +goes to school. The other? + +263 +00:21:11,560 --> 00:21:16,780 +The other goes to the university. Okay. One goes + +264 +00:21:16,780 --> 00:21:21,040 +to school. Another goes to the university. The + +265 +00:21:21,040 --> 00:21:26,500 +other? Okay, goes to work. Very good. Again, I + +266 +00:21:26,500 --> 00:21:31,860 +have three brothers. One goes to school. Another + +267 +00:21:31,860 --> 00:21:38,080 +goes to the university. The other goes to work. + +268 +00:21:38,140 --> 00:21:45,200 +Thank you. Now look, I have three books. Two are + +269 +00:21:45,200 --> 00:21:52,710 +mine. The other bookis yours okay or the other is + +270 +00:21:52,710 --> 00:21:56,470 +yours look i can say the other book the other book + +271 +00:21:56,470 --> 00:22:00,370 +this is an adjective followed by a noun or you can + +272 +00:22:00,370 --> 00:22:04,930 +say the other is yours okay i have three two are + +273 +00:22:04,930 --> 00:22:08,350 +mine the other is yours the other book is yours + +274 +00:22:08,350 --> 00:22:12,310 +okay i have three books one is mine the other + +275 +00:22:12,310 --> 00:22:17,110 +books are yours or the others are yours okay now i + +276 +00:22:17,110 --> 00:22:18,470 +have Three. + +277 +00:22:21,870 --> 00:22:26,110 +I have three pens. Give me your pen. Give me your + +278 +00:22:26,110 --> 00:22:33,270 +pen, please. Thank you. I have two pens. Okay? I + +279 +00:22:33,270 --> 00:22:38,670 +have two pens. Two are mine. Two are mine. The + +280 +00:22:38,670 --> 00:22:43,710 +other is yours. The other is yours. Or the other + +281 +00:22:43,710 --> 00:22:52,010 +pen is yours. Okay? Or, you know, give me another + +282 +00:22:52,010 --> 00:22:55,850 +pen for you. You have another pen? Yeah, I want + +283 +00:22:55,850 --> 00:22:56,530 +from here. + +284 +00:23:00,270 --> 00:23:05,690 +Thank you. Look, I have three pens. I have three + +285 +00:23:05,690 --> 00:23:11,010 +pens. One is mine. The others are yours. Or the + +286 +00:23:11,010 --> 00:23:15,450 +other pens are yours. Okay? The others or the + +287 +00:23:15,450 --> 00:23:18,690 +other pens are yours. Thank you. Now this is the + +288 +00:23:18,690 --> 00:23:22,490 +same example. The meaning of other or others, all + +289 +00:23:22,490 --> 00:23:27,730 +that remains. All that remains. Okay? Now I have + +290 +00:23:27,730 --> 00:23:34,600 +two pens. One is red, the other is black. The + +291 +00:23:34,600 --> 00:23:39,040 +other, what remains? This remains another one is + +292 +00:23:39,040 --> 00:23:43,960 +black. Or the rest of a specific group. That's + +293 +00:23:43,960 --> 00:23:51,040 +right. Now, read this example, please. I will be + +294 +00:23:51,040 --> 00:23:55,100 +here for another three days, three years. I need + +295 +00:23:55,100 --> 00:24:00,990 +another five dollars. We drop another 10 mils. + +296 +00:24:00,990 --> 00:24:04,370 +Okay, thank you very much. Go on. Another is used + +297 +00:24:04,370 --> 00:24:09,750 +as an adjective with the expression of time. + +298 +00:24:10,030 --> 00:24:12,990 +Expressions of time, three years, okay. Money. + +299 +00:24:13,450 --> 00:24:16,250 +Yeah, money, five dollars, yeah. And this + +300 +00:24:28,000 --> 00:24:31,300 +Thank you very much. Now when I say I will be + +301 +00:24:31,300 --> 00:24:36,450 +here.For another three years. Another three years. + +302 +00:24:36,770 --> 00:24:40,710 +It means what? Additional more three years, okay? + +303 +00:24:41,450 --> 00:24:44,510 +More three years. It is used with an expression of + +304 +00:24:44,510 --> 00:24:49,770 +time. It is used as an adjective, okay? Now, I + +305 +00:24:49,770 --> 00:24:54,410 +need another five, another, more. Okay, extra + +306 +00:24:54,410 --> 00:24:59,950 +more. It is used with what? Money, right? Now, we + +307 +00:24:59,950 --> 00:25:03,670 +drove another 10 miles. Another 10 miles. Used + +308 +00:25:03,670 --> 00:25:06,970 +again with expressions of distance. And they are + +309 +00:25:06,970 --> 00:25:10,530 +used as what? As adjectives. That's right. Thank + +310 +00:25:10,530 --> 00:25:16,290 +you. Look at this example. Look at this example. + +311 +00:25:17,720 --> 00:25:19,500 +Who wants to start? Yes, please. + +312 +00:25:24,000 --> 00:25:28,200 +Come here, please. Come, come, come. + +313 +00:25:43,910 --> 00:25:46,610 +Look at your hand. You have five fingers. One is + +314 +00:25:46,610 --> 00:25:52,730 +your thumb. Other is your index finger. Another is + +315 +00:25:52,730 --> 00:25:55,470 +your middle finger. + +316 +00:26:14,910 --> 00:26:19,970 +Another finger is your ring finger. Capital. + +317 +00:26:23,510 --> 00:26:24,930 +Capital. Capital. + +318 +00:26:28,350 --> 00:26:28,590 +Capital. + +319 +00:26:31,530 --> 00:26:31,890 +Capital. + +320 +00:26:34,750 --> 00:26:35,030 +Capital. + +321 +00:26:39,310 --> 00:26:40,930 +And the other finger. + +322 +00:26:44,230 --> 00:26:48,350 +Take just a minute. + +323 +00:26:54,540 --> 00:26:59,280 +What's that? Between A and it is one word. You are + +324 +00:26:59,280 --> 00:27:01,500 +right. This is one word. Don't keep space between + +325 +00:27:01,500 --> 00:27:04,880 +them. Now look. Look at your hand. All of you + +326 +00:27:04,880 --> 00:27:07,800 +please look at your hand. How many fingers do you + +327 +00:27:07,800 --> 00:27:14,220 +have? Five. One is your thumb. One is your thumb. + +328 +00:27:14,760 --> 00:27:20,040 +Another is your index. Okay. Another is your + +329 +00:27:20,040 --> 00:27:26,880 +middle finger. Another ring. The other. The other + +330 +00:27:26,880 --> 00:27:30,080 +means what? The last. Okay. The other means the + +331 +00:27:30,080 --> 00:27:32,680 +last. Thank you very much. Okay. Is that clear? + +332 +00:27:32,860 --> 00:27:36,120 +Yeah. Can you, yes, do number two. Yeah. Come + +333 +00:27:36,120 --> 00:27:43,170 +please. Number three. Number three. Yeah. That's + +334 +00:27:43,170 --> 00:27:46,630 +right. One is your right hand, the other is your + +335 +00:27:46,630 --> 00:27:49,690 +left hand. Good. Yes, come please. + +336 +00:28:01,310 --> 00:28:09,010 +Clean the answers. Read. I lost my dictionary, so + +337 +00:28:09,010 --> 00:28:12,150 +I bought another. So, I bought another. Thank you. + +338 +00:28:13,100 --> 00:28:13,820 +Good. Yeah. + +339 +00:28:18,700 --> 00:28:23,080 +Can you + +340 +00:28:23,080 --> 00:28:27,060 +say, I bought one? Now you can say, I bought + +341 +00:28:27,060 --> 00:28:29,820 +another one. You can say, I bought another one. + +342 +00:28:30,180 --> 00:28:33,840 +Okay. But now what does he, what does he want? + +343 +00:28:34,360 --> 00:28:37,560 +Complete the sentences with a form of other. In + +344 +00:28:37,560 --> 00:28:39,700 +this exercise, you should use other, but in + +345 +00:28:39,700 --> 00:28:43,390 +writing, you can say, I bought another one. Okay? + +346 +00:28:45,110 --> 00:28:48,510 +Yes, number five. Read it, please. Some people + +347 +00:28:48,510 --> 00:28:53,350 +have the hair. The others have the... Just a + +348 +00:28:53,350 --> 00:28:53,930 +minute, wait. + +349 +00:28:59,730 --> 00:29:00,250 +Now, + +350 +00:29:02,850 --> 00:29:08,110 +why others, not the others? Please, wait. Listen. + +351 +00:29:08,370 --> 00:29:10,830 +Why others, not the others? You said the others. + +352 +00:29:11,030 --> 00:29:12,330 +Why did you change your mind? + +353 +00:29:16,920 --> 00:29:21,440 +Now good, some people have red hair, others have + +354 +00:29:21,440 --> 00:29:26,300 +what? Brown hair. Now listen, if I have three + +355 +00:29:26,300 --> 00:29:31,000 +groups of people, okay? The first group has what? + +356 +00:29:31,860 --> 00:29:37,160 +Yes, they have red hair. The other group, their + +357 +00:29:37,160 --> 00:29:43,380 +hair is what? Brown. I say red, brown, the others. + +358 +00:29:43,840 --> 00:29:47,260 +The others, okay? The others means the last. But + +359 +00:29:47,260 --> 00:29:51,260 +when I say others have brown hair, others doesn't + +360 +00:29:51,260 --> 00:29:55,800 +mean the last, right? Because you have other types + +361 +00:29:55,800 --> 00:29:58,920 +of other colors of hair. Okay, I did not talk + +362 +00:29:58,920 --> 00:30:03,560 +about all the colors of hairs. Yeah, come. You + +363 +00:30:03,560 --> 00:30:07,580 +want to ask? Okay, so after here, get ready. + +364 +00:30:14,560 --> 00:30:22,620 +Okay, some people. Okay, other people. Good. Yes, + +365 +00:30:22,680 --> 00:30:25,640 +come please. After here, get ready. + +366 +00:30:32,720 --> 00:30:33,180 +The other. + +367 +00:30:38,460 --> 00:30:45,080 +Okay, I have four children. One of them has red + +368 +00:30:45,080 --> 00:30:51,020 +hair. The other children. It means what? The last + +369 +00:30:51,020 --> 00:30:53,740 +of the group. That's right. Thank you. The other + +370 +00:30:53,740 --> 00:30:57,820 +children. And finally, yes, come please. + +371 +00:31:27,570 --> 00:31:30,310 +Any question on the exercise? + +372 +00:31:38,010 --> 00:31:39,530 +This is another exercise. + +373 +00:31:42,210 --> 00:31:46,550 +Come. You did one, right? Okay, just wait. We want + +374 +00:31:46,550 --> 00:31:50,050 +to look for other students. Yeah? Again, the new + +375 +00:31:50,050 --> 00:31:52,710 +exercise. Who wants to start? Come. + +376 +00:31:57,690 --> 00:32:01,930 +They have three children. One has graduated from + +377 +00:32:01,930 --> 00:32:05,610 +college and has a job. Another is at Yale + +378 +00:32:05,610 --> 00:32:10,730 +University. The other is still at school. Very + +379 +00:32:10,730 --> 00:32:13,550 +good, thank you. Clean, clean and write. Clean the + +380 +00:32:13,550 --> 00:32:14,490 +previous answers. + +381 +00:32:23,530 --> 00:32:24,410 +How many prayers? + +382 +00:32:37,080 --> 00:32:41,720 +I would like some more books on this subject. Do + +383 +00:32:41,720 --> 00:32:45,040 +you have any others that you could definitely + +384 +00:32:45,040 --> 00:32:48,620 +read? Good, thank you. Any others? Next one. Come, + +385 +00:32:49,640 --> 00:32:50,460 +any others? + +386 +00:32:56,800 --> 00:33:02,680 +Number five for you, Murida. I would like to read + +387 +00:33:02,680 --> 00:33:05,540 +more books on this subject. Do you have any + +388 +00:33:05,540 --> 00:33:11,850 +others? Okay. Do you have any? Other. Any other. + +389 +00:33:11,990 --> 00:33:15,710 +Good. Any other box. Thank you. Any other box. + +390 +00:33:16,330 --> 00:33:22,730 +Yes. You two. Next two. Yes, you two. Come. Which + +391 +00:33:22,730 --> 00:33:28,410 +one? Which one you did? Number five? Yes, she + +392 +00:33:28,410 --> 00:33:30,870 +doesn't read any other. You are right. Thank you. + +393 +00:33:36,700 --> 00:33:38,460 +Okay, clean then write. + +394 +00:33:45,320 --> 00:33:51,260 +But what? Others prefer. Thank you. Others prefer. + +395 +00:33:52,220 --> 00:33:59,820 +Good. Yeah. Number seven, + +396 +00:33:59,980 --> 00:34:00,460 +almost. + +397 +00:34:03,200 --> 00:34:07,850 +Another five minutes. Good. Thank you. Yes, + +398 +00:34:07,930 --> 00:34:13,970 +please, come. Okay. Then you, then you, and then + +399 +00:34:13,970 --> 00:34:14,290 +you. + +400 +00:34:17,950 --> 00:34:23,850 +Yes, another. + +401 +00:34:25,170 --> 00:34:26,650 +What is the electric light? + +402 +00:34:32,470 --> 00:34:37,200 +Okay. What do you think? Is it others or the + +403 +00:34:37,200 --> 00:34:41,620 +others? Others. Why others, not the others? The + +404 +00:34:41,620 --> 00:34:45,060 +others, it means the last. You talked about all + +405 +00:34:45,060 --> 00:34:48,280 +the inventions and still you have some inventions + +406 +00:34:48,280 --> 00:34:53,560 +you didn't talk about. So the others are the last. + +407 +00:34:53,720 --> 00:34:56,980 +But others, it means there are a lot of + +408 +00:34:56,980 --> 00:35:03,540 +inventions. Others, good. Thank you. Next one. In + +409 +00:35:03,540 --> 00:35:08,540 +talking as early as six months, others don't speak + +410 +00:35:08,540 --> 00:35:12,520 +until they are more than two years old. Others. + +411 +00:35:12,640 --> 00:35:16,300 +Okay, thank you. Others. + +412 +00:35:19,140 --> 00:35:30,400 +Good. Common one + +413 +00:35:30,400 --> 00:35:32,780 +is in others are born + +414 +00:35:51,420 --> 00:35:53,600 +Other preposition, thank you, good. + +415 +00:35:59,700 --> 00:36:06,180 +Clean, then right. Okay, eleven for you, twelve + +416 +00:36:06,180 --> 00:36:14,780 +for you, thirteen for you. The other, + +417 +00:36:15,020 --> 00:36:19,880 +good. Instability, thank you. Yeah, twelve? + +418 +00:36:37,770 --> 00:36:42,030 +The others, very good. The others. Yes, you do the + +419 +00:36:42,030 --> 00:36:42,570 +last one. + +420 +00:36:57,170 --> 00:37:02,930 +Now, what did you write? For another. Good. Thank + +421 +00:37:02,930 --> 00:37:04,270 +you. And finally. + +422 +00:37:07,030 --> 00:37:07,710 +Finally. + +423 +00:37:21,600 --> 00:37:27,380 +What did you + +424 +00:37:27,380 --> 00:37:30,040 +say? Another, you are right, thank you. + +425 +00:37:35,330 --> 00:37:37,470 +Thank you very much. And do you have any question + +426 +00:37:37,470 --> 00:37:42,790 +on other, the other, others? Any question? I hope + +427 +00:37:42,790 --> 00:37:43,030 +so. + +428 +00:37:50,990 --> 00:37:52,370 +Okay, thank you. + diff --git a/PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/_edjjUoOcpA.srt b/PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/_edjjUoOcpA.srt new file mode 100644 index 0000000000000000000000000000000000000000..820146d4ec32b4646da48d562638c130f7bffed7 --- /dev/null +++ b/PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/_edjjUoOcpA.srt @@ -0,0 +1,1390 @@ +1 +00:00:21,180 --> 00:00:26,140 +Good morning to you all. How are you today? Last + +2 +00:00:26,140 --> 00:00:28,360 +time we started talking about the phrases. + +3 +00:00:45,290 --> 00:00:47,470 +The underlined words. Yes, please. They are a + +4 +00:00:47,470 --> 00:00:53,190 +group of words without a finite verb. A finite + +5 +00:00:53,190 --> 00:00:56,670 +verb, yes. So it is a phrase. What type of phrase? + +6 +00:00:56,830 --> 00:00:59,010 +Adjective phrase. Adjective phrase. Very good. + +7 +00:00:59,110 --> 00:01:03,120 +Because? Describe the noun. It describes the noun. + +8 +00:01:03,240 --> 00:01:05,960 +Thank you very much. And what would you like to + +9 +00:01:05,960 --> 00:01:09,160 +say about the other sentence? Yes, please. Don't + +10 +00:01:09,160 --> 00:01:12,160 +talk like that. Don't use phrases and verbs. + +11 +00:01:14,380 --> 00:01:17,980 +Describe the verb. Very good. Don't talk how? Like + +12 +00:01:17,980 --> 00:01:21,080 +that, okay? Thank you very much. Any question + +13 +00:01:21,080 --> 00:01:23,020 +about the previous material? No. + +14 +00:01:38,240 --> 00:01:41,600 +Now look at the examples. Who wants to read the + +15 +00:01:41,600 --> 00:01:47,360 +first example? Yes please. He wants to go home. He + +16 +00:01:47,360 --> 00:01:52,860 +wants what? He wants what? To go home. He wants to + +17 +00:01:52,860 --> 00:01:54,480 +go home. Where is the object? + +18 +00:01:57,350 --> 00:02:02,250 +Now listen. The object is usually an answer to + +19 +00:02:02,250 --> 00:02:06,690 +what? I ate an apple. What did I eat? I saw a + +20 +00:02:06,690 --> 00:02:09,890 +film. What did I see? I read a book. What did I + +21 +00:02:09,890 --> 00:02:14,550 +read? So the object is usually an answer to what? + +22 +00:02:15,290 --> 00:02:20,330 +He wants what? To go home. Thank you. So where is + +23 +00:02:20,330 --> 00:02:25,330 +the object again? To go home. The object is always + +24 +00:02:25,330 --> 00:02:31,760 +a noun. Right? The object is always a noun. You + +25 +00:02:31,760 --> 00:02:34,240 +remember when we talked about the adjective + +26 +00:02:34,240 --> 00:02:38,630 +phrases and the adverb phrases, we said, It is an + +27 +00:02:38,630 --> 00:02:43,410 +adjective phrase because it acts, it behaves as an + +28 +00:02:43,410 --> 00:02:46,970 +adjective. It is an adverb phrase because it + +29 +00:02:46,970 --> 00:02:53,310 +behaves as an adverb. But this noun phrase is used + +30 +00:02:53,310 --> 00:02:55,990 +as the noun, as the object. The object is the + +31 +00:02:55,990 --> 00:02:59,770 +noun. So now it is the noun. It is the object. So + +32 +00:02:59,770 --> 00:03:03,310 +the phrase itself is the object. Look at the other + +33 +00:03:03,310 --> 00:03:08,770 +sentence. Yes, Yasmin. I tried to get the sum + +34 +00:03:08,770 --> 00:03:14,250 +right. I tried what? To get the sum right. Okay, + +35 +00:03:14,430 --> 00:03:18,350 +thank you. So where is the object, Naveen? To get + +36 +00:03:18,350 --> 00:03:21,270 +the sum right. Thank you very much. Read the other + +37 +00:03:21,270 --> 00:03:25,310 +one, Hanin. To win a prize is my ambition. Good. + +38 +00:03:25,630 --> 00:03:29,710 +Now where is the subject? When I say this is my + +39 +00:03:29,710 --> 00:03:33,430 +ambition, where is the subject? My ambition. + +40 +00:03:34,010 --> 00:03:37,670 +Again. Just a minute. Wait, please give her a + +41 +00:03:37,670 --> 00:03:43,110 +chance. Where is the subject? Answer my question. + +42 +00:03:43,710 --> 00:03:47,750 +Very good. This is the subject. And the subject is + +43 +00:03:47,750 --> 00:03:52,910 +a phrase. It is a noun phrase. Very good. So, can + +44 +00:03:52,910 --> 00:03:56,430 +you tell me what is a noun phrase? Who can tell me + +45 +00:03:56,430 --> 00:04:02,280 +what is a noun phrase? We call it a noun phrase + +46 +00:04:02,280 --> 00:04:06,460 +because it acts like the subject or object. It is + +47 +00:04:06,460 --> 00:04:11,320 +the subject or the object, okay? And the subjects + +48 +00:04:11,320 --> 00:04:15,440 +and the objects are usually nouns. Are always + +49 +00:04:15,440 --> 00:04:19,220 +nouns. We cannot use other words as subjects or as + +50 +00:04:19,220 --> 00:04:22,780 +objects. They are usually nouns. So, a noun phrase + +51 +00:04:22,780 --> 00:04:26,740 +is used as the object or as the subject of the + +52 +00:04:26,740 --> 00:04:31,380 +sentence. Is that okay? Now, look at this + +53 +00:04:31,380 --> 00:04:35,520 +exercise. Number one, Noor, can you read? Pick out + +54 +00:04:35,520 --> 00:04:38,040 +the noun phrases in the following sentences. Yes, + +55 +00:04:38,120 --> 00:04:40,860 +where are the noun phrases? Good. His father + +56 +00:04:40,860 --> 00:04:45,560 +wished to speak to the headmaster. His father + +57 +00:04:45,560 --> 00:04:49,940 +wished. Yes, where is the phrase? To speak. To + +58 +00:04:49,940 --> 00:04:54,340 +speak. Listen, just a minute. His father wished + +59 +00:04:54,340 --> 00:05:00,000 +what? What? Ask yourself, what?to speak to the + +60 +00:05:00,000 --> 00:05:05,060 +headmaster so where is the phrase again okay to + +61 +00:05:05,060 --> 00:05:07,960 +speak this is the object okay this is the object + +62 +00:05:07,960 --> 00:05:13,160 +why it is the object okay uh sorry this is a noun + +63 +00:05:13,160 --> 00:05:17,020 +phrase why it is a noun phrase because it is the + +64 +00:05:17,020 --> 00:05:19,320 +object of the sentence thank you very much good + +65 +00:05:19,320 --> 00:05:25,580 +yes please next one to manage my students I + +66 +00:05:25,580 --> 00:05:29,520 +dislike what? Very good. This is the noun phrase. + +67 +00:05:29,660 --> 00:05:32,440 +Thank you very much. Good. Next one. Yes, please. + +68 +00:05:32,540 --> 00:05:37,460 +He denies stealing the money. He denies what? + +69 +00:05:37,880 --> 00:05:41,120 +Stealing the money. Okay. Stealing the money. + +70 +00:05:41,240 --> 00:05:46,780 +Thank you. Yeah. Have you ever tried climbing a + +71 +00:05:46,780 --> 00:05:53,340 +mountain? Very good. Tried what? Climbing a + +72 +00:05:53,340 --> 00:05:55,940 +mountain. Thank you very much. Horses prefer + +73 +00:05:55,940 --> 00:06:00,260 +living in dark stables. What prefer living in? + +74 +00:06:00,280 --> 00:06:04,140 +Yes, prefer what? Living in dark stables. Good. + +75 +00:06:04,860 --> 00:06:09,440 +Now, these are the answers. You can look at them. + +76 +00:06:09,920 --> 00:06:14,080 +What about the prepositional phrase? Now, we + +77 +00:06:14,080 --> 00:06:18,060 +talked about the adjective phrase, the adverb + +78 +00:06:18,060 --> 00:06:22,040 +phrase, and the noun phrase. The preposition + +79 +00:06:22,040 --> 00:06:29,140 +phrase is made at least of two words. Two words, a + +80 +00:06:29,140 --> 00:06:34,140 +preposition and another word. This word can be a + +81 +00:06:34,140 --> 00:06:41,290 +noun, can be a pronoun, can be a gerund, or A noun + +82 +00:06:41,290 --> 00:06:48,110 +clause. How? Now let's see. If you look at this + +83 +00:06:48,110 --> 00:06:52,430 +example, when I say at home, I have preposition + +84 +00:06:52,430 --> 00:06:57,670 +and noun. In time, preposition and noun. Okay, + +85 +00:06:57,910 --> 00:07:04,670 +from Sue. Preposition and noun. With me. For you. + +86 +00:07:06,290 --> 00:07:13,250 +Preposition and? Okay, by singing, by sleeping, by + +87 +00:07:13,250 --> 00:07:17,510 +eating. Okay, this is gerund. Now, as you see, + +88 +00:07:17,690 --> 00:07:22,610 +they are prepositional phrases. They are made of a + +89 +00:07:22,610 --> 00:07:26,890 +preposition and a noun, a pronoun or a gerund. + +90 +00:07:27,450 --> 00:07:33,490 +Now, look about what we need. about what we need. + +91 +00:07:33,590 --> 00:07:39,290 +We have a preposition and a noun clause. What is + +92 +00:07:39,290 --> 00:07:43,450 +the noun clause? Just wait, we are going to talk + +93 +00:07:43,450 --> 00:07:52,570 +about it. Now, from my grandfather, from my + +94 +00:07:52,570 --> 00:07:57,710 +grandmother, this is a preposition and this is a + +95 +00:07:57,710 --> 00:08:04,760 +modifier. A modifier is a specifier. It specifies + +96 +00:08:04,760 --> 00:08:09,260 +the noun. When I say grandmother, it can be any + +97 +00:08:09,260 --> 00:08:13,400 +grandmother. When I say your grandmother, it's + +98 +00:08:13,400 --> 00:08:18,360 +that. Okay. My grandmother, it made the noun + +99 +00:08:18,360 --> 00:08:23,700 +specific. So, we use what? A preposition, a + +100 +00:08:23,700 --> 00:08:28,680 +modifier, and a noun. Under the warm blanket. + +101 +00:08:29,620 --> 00:08:36,060 +again we use a preposition and modifiers okay and + +102 +00:08:36,060 --> 00:08:44,380 +now good now we know what is a prepositional + +103 +00:08:44,380 --> 00:08:48,720 +phrase yes at least it is made up of a preposition + +104 +00:08:48,720 --> 00:08:56,720 +and A noun, a pronoun or gerund or a noun clause. + +105 +00:08:56,860 --> 00:09:00,640 +It can be expanded. We can use also modifiers in a + +106 +00:09:00,640 --> 00:09:04,520 +noun, in a prepositional phrase. A prepositional + +107 +00:09:04,520 --> 00:09:11,760 +phrase usually behaves as an adjective or as an + +108 +00:09:11,760 --> 00:09:17,100 +adverb. Okay? So it functions usually as what? An + +109 +00:09:17,100 --> 00:09:20,880 +adjective or an adverb. How can I distinguish + +110 +00:09:20,880 --> 00:09:23,820 +between this and that? If you look at this + +111 +00:09:23,820 --> 00:09:28,180 +example. Yeah, who wants to read the example? Yes, + +112 +00:09:28,280 --> 00:09:32,600 +please. The book on the bathroom floor is stolen + +113 +00:09:32,600 --> 00:09:36,160 +from a shower stand. Thank you. Now, the book on + +114 +00:09:36,160 --> 00:09:42,280 +which one? which one so it answers the question + +115 +00:09:42,280 --> 00:09:45,820 +which one if it answers the question which one it + +116 +00:09:45,820 --> 00:09:49,820 +is an adjective phrase okay it functions as an + +117 +00:09:49,820 --> 00:09:53,840 +adjective phrase okay so a prepositional phrase + +118 +00:09:53,840 --> 00:09:57,920 +when answers the question which one it functions + +119 +00:09:57,920 --> 00:10:03,680 +as An adjective phrase. Good. Now which book? Now + +120 +00:10:03,680 --> 00:10:05,840 +look at the other one. Who can read the example? + +121 +00:10:06,060 --> 00:10:09,160 +Yes Khadija. The sweet potatoes in the vegetable + +122 +00:10:09,160 --> 00:10:12,990 +bin are green with mold. Okay, which ones? Which + +123 +00:10:12,990 --> 00:10:18,210 +ones? So, this prepositional phrase functions as + +124 +00:10:18,210 --> 00:10:22,110 +what? An adjective phrase. Now, what about the + +125 +00:10:22,110 --> 00:10:25,770 +prepositional phrase when it functions as an + +126 +00:10:25,770 --> 00:10:29,850 +adverb? When it functions as an adverb, you know, + +127 +00:10:30,950 --> 00:10:34,450 +adverb phrases and clauses usually answer + +128 +00:10:34,450 --> 00:10:40,550 +questions like what, like why, how, when, where, + +129 +00:10:40,850 --> 00:10:46,190 +okay? Now, Fadi. Yeah, who wants to read the + +130 +00:10:46,190 --> 00:10:48,470 +example? Hanin. + +131 +00:10:51,790 --> 00:10:54,950 +Okay, Fadi is stiff from yesterday's long football + +132 +00:10:54,950 --> 00:10:59,330 +practice. Thank you. How did he get stiff? So it + +133 +00:10:59,330 --> 00:11:04,030 +answers what? How? It answers how? So it functions + +134 +00:11:04,030 --> 00:11:08,630 +as? Adverb. Very good. Read the other one, please. + +135 +00:11:08,990 --> 00:11:09,230 +Yeah? + +136 +00:11:15,130 --> 00:11:21,130 +Okay, when did Jihad do this? Before class. Okay, + +137 +00:11:21,650 --> 00:11:26,150 +so before class, this is a prepositional phrase, + +138 +00:11:26,190 --> 00:11:32,470 +it acts or functions as? Thank you. And finally, + +139 +00:11:33,030 --> 00:11:34,490 +finally, yes please read. + +140 +00:11:41,690 --> 00:11:46,710 +Okay, where did we try the food? Okay. So again, + +141 +00:11:47,470 --> 00:11:49,810 +this is what, what would you say about this point? + +142 +00:11:50,750 --> 00:11:52,190 +Yes. What would you say? + +143 +00:11:55,830 --> 00:11:56,290 +Okay. + +144 +00:11:59,990 --> 00:12:04,240 +Thank you very much. Good. Now, let's come to + +145 +00:12:04,240 --> 00:12:09,860 +clauses okay so we talked about four types of + +146 +00:12:09,860 --> 00:12:17,180 +phrases let's come to clauses first of all what is + +147 +00:12:17,180 --> 00:12:22,720 +a clause we said a phrase is a group of related + +148 +00:12:22,720 --> 00:12:29,200 +words without a verb without what type of verb + +149 +00:12:29,200 --> 00:12:35,040 +finite verb and without Okay, of course, no verb, + +150 +00:12:35,160 --> 00:12:40,060 +no subject, no complete sense. So if this group of + +151 +00:12:40,060 --> 00:12:46,520 +words contains a finite verb, has a subject and a + +152 +00:12:46,520 --> 00:12:49,660 +predicate. First of all, what is the subject and + +153 +00:12:49,660 --> 00:12:51,660 +what is the predicate? Who can give me a sentence? + +154 +00:12:54,800 --> 00:12:56,080 +Give me a sentence. + +155 +00:13:02,360 --> 00:13:11,400 +Again, give me any sentence, yeah? I bought a + +156 +00:13:11,400 --> 00:13:19,700 +red shirt Okay, where is the subject? I Now + +157 +00:13:19,700 --> 00:13:23,220 +everything said about the subject is called a + +158 +00:13:23,220 --> 00:13:27,620 +predicate Okay, so everything said about the + +159 +00:13:27,620 --> 00:13:31,920 +subject is called what? Predicate The sentence + +160 +00:13:31,920 --> 00:13:36,120 +contains two main parts, a subject and a + +161 +00:13:36,120 --> 00:13:39,820 +predicate. The subject, you know the subject, the + +162 +00:13:39,820 --> 00:13:44,320 +doer of the action. And the predicate, everything + +163 +00:13:44,320 --> 00:13:47,640 +is said about the subject. I hope this is easy and + +164 +00:13:47,640 --> 00:13:50,300 +clear. Okay, can you give me another sentence? + +165 +00:13:51,120 --> 00:13:53,960 +Another sentence from your aunt. She bought a + +166 +00:13:53,960 --> 00:14:00,740 +shirt. What did you buy? Yes, what did you buy? I + +167 +00:14:00,740 --> 00:14:04,140 +bought a bag. Okay. Tell me about where is the + +168 +00:14:04,140 --> 00:14:08,600 +subject and the predicate? I is a subject and + +169 +00:14:08,600 --> 00:14:12,060 +bought a bag is a predicate. Thank you. The + +170 +00:14:12,060 --> 00:14:15,660 +weather is getting very cold. The weather is + +171 +00:14:15,660 --> 00:14:19,300 +getting very cold. Yeah? The weather is subject + +172 +00:14:19,300 --> 00:14:24,140 +and it's getting very cold is the predicate. Thank + +173 +00:14:24,140 --> 00:14:30,220 +you. Now look. He has a chain which is made of + +174 +00:14:30,220 --> 00:14:30,600 +gold. + +175 +00:14:35,140 --> 00:14:43,160 +It is made of gold. Look at the underlying group + +176 +00:14:43,160 --> 00:14:48,840 +of words. It has a subject and it has a predicate. + +177 +00:14:49,180 --> 00:14:53,460 +It has a subject and a predicate. Does it give you + +178 +00:14:53,460 --> 00:14:58,900 +a full meaning? Yes. Okay. Now, in fact, it gives + +179 +00:14:58,900 --> 00:15:03,460 +a full meaning in the sentence. When you say, + +180 +00:15:04,020 --> 00:15:07,940 +which is made of gold, what is it? Or it is made + +181 +00:15:07,940 --> 00:15:11,280 +of gold. When you read the whole sentence, he has + +182 +00:15:11,280 --> 00:15:15,140 +bought a chain, and you read the other clause, it + +183 +00:15:15,140 --> 00:15:18,020 +gives a full meaning, a complete sense, right? + +184 +00:15:18,640 --> 00:15:22,940 +Now, let's look. This group of words contains a + +185 +00:15:22,940 --> 00:15:26,000 +subject and a predicate. And of course, the + +186 +00:15:26,000 --> 00:15:30,220 +predicate contains a finite verb. It has a finite + +187 +00:15:30,220 --> 00:15:35,840 +verb. A verb which has a tense. What are the types + +188 +00:15:35,840 --> 00:15:42,460 +of clauses? It is very easy. You remember an + +189 +00:15:42,460 --> 00:15:48,900 +adjective phrase? What is an adjective phrase? + +190 +00:15:50,540 --> 00:15:55,420 +What is it? It is the one which describes the + +191 +00:15:55,420 --> 00:15:58,700 +noun. And the adjective clause is the one which + +192 +00:15:59,870 --> 00:16:04,090 +describes the noun okay what is the adverb phrase + +193 +00:16:04, + +223 +00:18:20,160 --> 00:18:23,020 +describes the verb. That's it, simply. It + +224 +00:18:23,020 --> 00:18:25,200 +describes the verb. It does the work of the + +225 +00:18:25,200 --> 00:18:31,960 +adverb. Okay? Now look at this exercise. When you + +226 +00:18:31,960 --> 00:18:33,920 +start, please read the introduction. + +227 +00:18:40,420 --> 00:18:47,100 +Because you have done this, I shall punish you. + +228 +00:18:47,100 --> 00:18:47,500 +Why? + +229 +00:18:51,420 --> 00:18:56,240 +Because you + +230 +00:18:56,240 --> 00:18:59,700 +have done this. Because you have done this. This + +231 +00:18:59,700 --> 00:19:04,680 +is what? An adverbic clause. Thank you very much. + +232 +00:19:04,780 --> 00:19:09,600 +Good. Yes, please. Next one. Number two. + +233 +00:19:13,560 --> 00:19:18,300 +Why? Why did I speak to his brother? No, no, no. + +234 +00:19:18,380 --> 00:19:22,560 +She. This is for her. Yeah, go on. Where is the + +235 +00:19:22,560 --> 00:19:25,360 +adverbic clause? Ask yourself why? + +236 +00:19:29,590 --> 00:19:34,070 +Why did I speak to his brother? Now, what does in + +237 +00:19:34,070 --> 00:19:37,830 +English, what does "as" mean? Because. Okay, good. + +238 +00:19:39,830 --> 00:19:43,010 +Okay, so as he was not there. Thank you very much. + +239 +00:19:43,130 --> 00:19:45,130 +Next one. He finished first. + +240 +00:19:55,680 --> 00:20:00,000 +Yes. Though he began late. Very good. Thank you. + +241 +00:20:00,240 --> 00:20:06,520 +Yeah. Will you wait till I return? Yeah. Will I + +242 +00:20:06,520 --> 00:20:12,360 +return? Where is the adverb closed? Till I return. + +243 +00:20:12,380 --> 00:20:15,440 +Till I return. Thank you very much. Yes, please. + +244 +00:20:16,460 --> 00:20:19,400 +Just as he entered the room, the clock struck. + +245 +00:20:21,820 --> 00:20:27,740 +Okay, when? Just as + +246 +00:20:27,740 --> 00:20:32,980 +he entered the room. Okay. Now, when did the clock + +247 +00:20:32,980 --> 00:20:37,060 +what? Struck. If I begin with dead, what shall I + +248 +00:20:37,060 --> 00:20:44,000 +say? One speaker. When did the clock strike? Take + +249 +00:20:44,000 --> 00:20:47,680 +care, okay? When did the clock strike? Any + +250 +00:20:47,680 --> 00:20:48,940 +question on this exercise? + +251 +00:20:55,750 --> 00:21:03,190 +Adjective clauses. Adjective clauses, okay? Now, + +252 +00:21:03,450 --> 00:21:09,270 +number one. Read, please. Say, a little lamb, a + +253 +00:21:09,270 --> 00:21:15,010 +little cat. Okay? You know the lamb? Okay, good. + +254 +00:21:16,150 --> 00:21:20,090 +Whose fleece? Whose fleece was white as snow. + +255 +00:21:20,430 --> 00:21:24,970 +Okay, now the underlined words, whose fleece was + +256 +00:21:24,970 --> 00:21:28,190 +as white as snow. Yes. Yes, what would you + +257 +00:21:28,190 --> 00:21:30,370 +comment? What would you say about this group of + +258 +00:21:30,370 --> 00:21:32,290 +words? Yeah. + +259 +00:21:35,690 --> 00:21:37,910 +It is an adjective clause. Very good. Thank you. + +260 +00:21:38,030 --> 00:21:40,950 +Why it is an adjective clause? Yes, please. It has + +261 +00:21:40,950 --> 00:21:45,250 +a subject and a precedence. A predicate. And it + +262 +00:21:45,250 --> 00:21:49,490 +behaves as an adjective. Okay, thank you. Behaves + +263 +00:21:49,490 --> 00:21:53,130 +describes the noun. Naveen, number two. The letter + +264 +00:21:53,130 --> 00:21:56,310 +from money which was badly needed. Okay, what type + +265 +00:21:56,310 --> 00:22:00,550 +of money? Okay, money. It describes what? Money. + +266 +00:22:01,170 --> 00:22:03,910 +Which was badly needed. Yes, go on Naveen. What + +267 +00:22:03,910 --> 00:22:04,450 +would you say? + +268 +00:22:07,690 --> 00:22:13,310 +About the underlined words. Money. Okay, it is an + +269 +00:22:13,310 --> 00:22:15,670 +adjective clause. Thank you very much. Why it is + +270 +00:22:15,670 --> 00:22:19,530 +an adjective clause, Yasmeen? Because it describes + +271 +00:22:19,530 --> 00:22:24,490 +the noun. Money. What type of money? Okay, thank + +272 +00:22:24,490 --> 00:22:27,130 +you. The other one, please. Yes? + +273 +00:22:29,960 --> 00:22:38,060 +Yes, they never fail who die in a great cause. + +274 +00:22:40,560 --> 00:22:45,540 +Okay, it means people who die. It describes what? + +275 +00:22:47,300 --> 00:22:50,960 +The noun. Thank you. So, what would you say about + +276 +00:22:50,960 --> 00:22:55,060 +the adjective clause? The adjective clause is + +277 +00:22:55,060 --> 00:22:58,360 +contained by a subject and a predicate. Contains a + +278 +00:22:58,360 --> 00:23:01,480 +subject and a predicate as the other clauses, + +279 +00:23:01,700 --> 00:23:04,180 +good. It describes a noun and behave as + +280 +00:23:04,180 --> 00:23:07,100 +adjectives. Okay, good. Thank you very much. Now + +281 +00:23:07,100 --> 00:23:09,960 +look at the exercise. Number one, read the + +282 +00:23:09,960 --> 00:23:10,460 +introduction. + +283 +00:23:14,080 --> 00:23:14,680 +Yes, + +284 +00:23:20,340 --> 00:23:25,710 +where are the adjective clauses? The house that I + +285 +00:23:25,710 --> 00:23:29,510 +live in. The house. + +286 +00:23:31,230 --> 00:23:35,710 +Which house? Please, we want one speaker. Okay? + +287 +00:23:36,490 --> 00:23:39,410 +One speaker. Don't talk together. She's speaking. + +288 +00:23:40,110 --> 00:23:47,650 +Yeah, she can. Which house? That I live in. Very + +289 +00:23:47,650 --> 00:23:50,350 +good. Now, when I say the house, it can be any + +290 +00:23:50,350 --> 00:23:54,730 +house, right? The adjective also specifies the + +291 +00:23:54,730 --> 00:23:59,470 +noun, right? The adjective, when I say girl, it + +292 +00:23:59,470 --> 00:24:04,550 +can be any girl, right? But the tall girl, it + +293 +00:24:04,550 --> 00:24:09,310 +makes the noun specific. House, which house? That + +294 +00:24:09,310 --> 00:24:14,580 +I live in. That I live in. Yeah, thank you. I have + +295 +00:24:14,580 --> 00:24:17,080 +a little shadow which goes in and out with me. + +296 +00:24:17,460 --> 00:24:21,660 +Which goes in and out with me. Thank you. That's + +297 +00:24:21,660 --> 00:24:25,580 +right. Thank you. Yeah? The dog that bites doesn't + +298 +00:24:25,580 --> 00:24:29,980 +bite. Adjective clauses that bites doesn't bite. + +299 +00:24:30,060 --> 00:24:33,720 +That bites doesn't. Okay, the dog. Now, again, + +300 +00:24:33,800 --> 00:24:39,410 +where is the adjective clause? That bites. That + +301 +00:24:39,410 --> 00:24:43,050 +bites. Okay? The dog that bites. Which dog? That + +302 +00:24:43,050 --> 00:24:47,630 +bites. Okay. Thank you. Yes, please. He tells a + +303 +00:24:47,630 --> 00:24:53,710 +tale that sounds untrue. That sounds untrue. Okay, + +304 +00:24:53,890 --> 00:24:58,490 +good. Thank you. And finally. Yes? It is an owl. + +305 +00:24:58,830 --> 00:25:02,870 +Owl and that one. That's not a nobody and a god. + +306 +00:25:03,090 --> 00:25:10,810 +That's not. That? Now, which wind? Which wind? + +307 +00:25:12,930 --> 00:25:19,570 +That blows nobody any good. Okay? That blows + +308 +00:25:19,570 --> 00:25:24,930 +nobody any good. Okay? It describes what? The + +309 +00:25:24,930 --> 00:25:30,350 +noun. Good. Now, you can look at the answers. And + +310 +00:25:30,350 --> 00:25:33,710 +finally, noun clauses. + +311 +00:25:34,970 --> 00:25:37,990 +Now Nick closes. Who wants to start? Who wants to + +312 +00:25:37,990 --> 00:25:41,960 +speak? Now it's your turn, Morida. I expect that I + +313 +00:25:41,960 --> 00:25:44,400 +shall get a prize. Yes, what would you say about + +314 +00:25:44,400 --> 00:25:48,660 +this sentence? That I shall get a prize. It has a + +315 +00:25:48,660 --> 00:25:52,180 +subject and a predicate. A predicate, so it is a + +316 +00:25:52,180 --> 00:25:55,260 +clause. So, what type of a clause? It's not a + +317 +00:25:55,260 --> 00:25:59,460 +clause. Why? Because it has a subject. It is a + +318 +00:25:59,460 --> 00:26:00,580 +subject. + +319 +00:26:02,920 --> 00:26:05,740 +Very good. It is the object. Where is the object + +320 +00:26:05,740 --> 00:26:09,730 +of the sentence? I expect what? I expect what? + +321 +00:26:10,230 --> 00:26:13,330 +That I shall get a prize, okay? So this is the + +322 +00:26:13,330 --> 00:26:17,550 +object, right? This is the object. Of course, + +323 +00:26:17,850 --> 00:26:20,930 +because it is the object, this clause is an + +324 +00:26:20,930 --> 00:26:25,850 +object, it is a noun clause. Next one. That you + +325 +00:26:25,850 --> 00:26:31,010 +should say this is very strange. A subject and a + +326 +00:26:31,010 --> 00:26:33,450 +predicate. Where is the subject and where is the + +327 +00:26:33,450 --> 00:26:37,390 +predicate? That you should say they are predicate. + +328 +00:26:38,900 --> 00:26:40,080 +Where is the subject? + +329 +00:26:47,300 --> 00:26:47,780 +Okay. + +330 +00:26:50,740 --> 00:26:53,600 +Now where is the clause? Where is the clause? + +331 +00:26:56,440 --> 00:26:59,160 +Okay, thank you. And where is the subject of the + +332 +00:26:59,160 --> 00:27:02,080 +sentence? That you should say this is very + +333 +00:27:02,080 --> 00:27:03,960 +strange. Where is the subject of the sentence? + +334 +00:27:05,630 --> 00:27:11,930 +Okay, read it, read it again. That you… + +335 +00:27:15,530 --> 00:27:18,990 +it is the subject of the sentence. Good. And + +336 +00:27:18,990 --> 00:27:22,490 +because this clause is used as the subject of the + +337 +00:27:22,490 --> 00:27:26,110 +sentence, it is what? It is a noun clause, okay? + +338 +00:27:26,450 --> 00:27:30,580 +So, what are noun clauses? Noun clauses also it + +339 +00:27:30,580 --> 00:27:38,260 +contains by subject and predicate and maybe it + +340 +00:27:38,260 --> 00:27:44,200 +should be object or subject. So, thank you very + +341 +00:27:44,200 --> 00:27:49,160 +much. A noun clause is, you know, it contains a + +342 +00:27:49,160 --> 00:27:52,560 +subject and a predicate as all the other clauses + +343 +00:27:52,560 --> 00:27:55,920 +and it is the subject or the object of the + +344 +00:27:55,920 --> 00:28:01,170 +sentence. I hope it is clear. Now look at the + +345 +00:28:01,170 --> 00:28:10,190 +exercise. Yes, you there at the back. Start the + +346 +00:28:10,190 --> 00:28:10,670 +introduction. + +347 +00:28:18,270 --> 00:28:25,670 +Yeah. Now I wonder. Yeah, go on. I wonder what? + +348 +00:28:28,070 --> 00:28:34,090 +Okay, good. What's that? Very good. One. It is one + +349 +00:28:34,090 --> 00:28:37,630 +clause. Thank you. Your neighbor. Yeah. + +350 +00:28:43,530 --> 00:28:49,190 +Okay. I feel what? Just a minute. Just a minute. I + +351 +00:28:49,190 --> 00:28:52,810 +feel what? What's the answer to what? Okay. So + +352 +00:28:52,810 --> 00:28:57,150 +where is the clause? Where is it? Read it again. + +353 +00:28:57,230 --> 00:28:58,830 +Read the clause only. + +354 +00:29:01,510 --> 00:29:04,810 +That I shall fail. Thank you. Good. It is a noun + +355 +00:29:04,810 --> 00:29:07,870 +clause because it is the object of the sentence. + +356 +00:29:08,030 --> 00:29:09,430 +The one behind you, Yasmeen. + +357 +00:29:12,230 --> 00:29:17,530 +Behind you. That you have come against me. + +358 +00:29:20,750 --> 00:29:26,210 +Okay, that you have come. What pleases me? That + +359 +00:29:26,210 --> 00:29:32,590 +you have come. Why is it a noun clause? Why is it + +360 +00:29:32,590 --> 00:29:37,430 +a noun clause? It is the subject of the sentence. + +361 +00:29:37,590 --> 00:29:40,350 +It is the subject of the sentence. Thank you. Next + +362 +00:29:40,350 --> 00:29:44,130 +one. He implied that he would come with a noun + +363 +00:29:44,130 --> 00:29:47,610 +clause because it is the subject and object of the + +364 +00:29:47,610 --> 00:29:52,820 +sentence. He replied that he would come. Okay, it + +365 +00:29:52,820 --> 00:29:57,600 +is the object. Thank you. And the last one? Yes? I + +366 +00:29:57,600 --> 00:30:01,540 +thought that it would be a fine day. That it would + +367 +00:30:01,540 --> 00:30:06,640 +be a fine day. It's now closed because it's the + +368 +00:30:06,640 --> 00:30:09,000 +object of Islam. Thank you very much. Now look. + +369 +00:30:11,060 --> 00:30:16,220 +This is an exercise. Okay? It contains different + +370 +00:30:16,220 --> 00:30:19,640 +sentences, different phrases, and different + +371 +00:30:19,640 --> 00:30:26,020 +clauses. Underline. Read. The underline, not now. + +372 +00:30:26,940 --> 00:30:31,630 +This is homework. Okay? And read the underlined + +373 +00:30:31,630 --> 00:30:35,330 +group of words carefully. Decide whether it is a + +374 +00:30:35,330 --> 00:30:39,090 +phrase or a clause. And what type of a phrase or + +375 +00:30:39,090 --> 00:30:41,590 +what type of a clause. Then tick the right box + +376 +00:30:41,590 --> 00:30:45,410 +there. Is that okay? Yes. Thank you very much and + +377 +00:30:45,410 --> 00:30:46,470 +see you on Saturday. diff --git a/PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/_edjjUoOcpA_raw.json b/PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/_edjjUoOcpA_raw.json new file mode 100644 index 0000000000000000000000000000000000000000..7142b3452ea3aeffefc803b80ddbc1e9ec575779 --- /dev/null +++ b/PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/_edjjUoOcpA_raw.json @@ -0,0 +1 @@ +{"segments": [{"id": 1, "seek": 2836, "start": 21.18, "end": 28.36, "text": " Good morning to you all. How are you today? Last time we started talking about the phrases.", "tokens": [2205, 2446, 281, 291, 439, 13, 1012, 366, 291, 965, 30, 5264, 565, 321, 1409, 1417, 466, 264, 20312, 13], "avg_logprob": -0.14053199972425187, "compression_ratio": 1.069767441860465, "no_speech_prob": 0.0, "words": [{"start": 21.18, "end": 21.46, "word": " Good", "probability": 0.783203125}, {"start": 21.46, "end": 21.72, "word": " morning", "probability": 0.88818359375}, {"start": 21.72, "end": 21.9, "word": " to", "probability": 0.9541015625}, {"start": 21.9, "end": 22.04, "word": " you", "probability": 0.96337890625}, {"start": 22.04, "end": 22.38, "word": " all.", "probability": 0.95068359375}, {"start": 23.3, "end": 23.46, "word": " How", "probability": 0.83740234375}, {"start": 23.46, "end": 23.62, "word": " are", "probability": 0.9501953125}, {"start": 23.62, "end": 23.74, "word": " you", "probability": 0.9697265625}, {"start": 23.74, "end": 24.14, "word": " today?", "probability": 0.82177734375}, {"start": 25.54, "end": 26.14, "word": " Last", "probability": 0.78271484375}, {"start": 26.14, "end": 26.46, "word": " time", "probability": 0.8857421875}, {"start": 26.46, "end": 26.64, "word": " we", "probability": 0.748046875}, {"start": 26.64, "end": 27.02, "word": " started", "probability": 0.91845703125}, {"start": 27.02, "end": 27.5, "word": " talking", "probability": 0.84375}, {"start": 27.5, "end": 27.84, "word": " about", "probability": 0.91748046875}, {"start": 27.84, "end": 28.02, "word": " the", "probability": 0.83740234375}, {"start": 28.02, "end": 28.36, "word": " phrases.", "probability": 0.83642578125}], "temperature": 1.0}, {"id": 2, "seek": 5961, "start": 45.29, "end": 59.61, "text": " The underlined words. Yes, please. They are a group of words without a finite verb. A finite verb, yes. So it is a phrase. What type of phrase? Adjective phrase. Adjective phrase. Very good. 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It describes the noun. Thank you very much. And what would you like to say about the other sentence? Yes, please. Don't talk like that. Don't use phrases and verbs. Describe the verb. Very good. Don't talk how? Like that, okay? Thank you very much. Any question about the previous material? 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Who wants to read the first example? Yes please. He wants to go home. He wants what? He wants what? To go home. He wants to go home. Where is the object?", "tokens": [823, 574, 412, 264, 5110, 13, 2102, 2738, 281, 1401, 264, 700, 1365, 30, 1079, 1767, 13, 634, 2738, 281, 352, 1280, 13, 634, 2738, 437, 30, 634, 2738, 437, 30, 1407, 352, 1280, 13, 634, 2738, 281, 352, 1280, 13, 2305, 307, 264, 2657, 30], "avg_logprob": -0.13987699277857515, "compression_ratio": 1.651376146788991, "no_speech_prob": 0.0, "words": [{"start": 98.24, "end": 98.56, "word": " Now", "probability": 0.859375}, {"start": 98.56, "end": 98.8, "word": " look", "probability": 0.6904296875}, {"start": 98.8, "end": 98.94, "word": " at", "probability": 0.9677734375}, {"start": 98.94, "end": 99.06, "word": " the", "probability": 0.87646484375}, {"start": 99.06, "end": 99.62, "word": " examples.", "probability": 0.77880859375}, {"start": 100.7, "end": 100.84, "word": " Who", "probability": 0.8525390625}, {"start": 100.84, "end": 101.12, "word": " wants", "probability": 0.8515625}, {"start": 101.12, "end": 101.28, "word": " to", "probability": 0.96728515625}, {"start": 101.28, "end": 101.42, "word": " read", "probability": 0.95947265625}, {"start": 101.42, "end": 101.6, "word": " the", "probability": 0.921875}, {"start": 101.6, "end": 101.86, "word": " first", "probability": 0.8779296875}, {"start": 101.86, "end": 102.36, "word": " example?", "probability": 0.970703125}, {"start": 103.04, "end": 103.24, "word": " Yes", "probability": 0.8095703125}, {"start": 103.24, "end": 103.64, "word": " please.", "probability": 0.5341796875}, {"start": 104.36, "end": 104.58, "word": " He", "probability": 0.76416015625}, {"start": 104.58, "end": 106.28, "word": " wants", "probability": 0.85498046875}, {"start": 106.28, "end": 106.48, "word": " to", "probability": 0.97021484375}, {"start": 106.48, "end": 106.68, "word": " go", "probability": 0.966796875}, {"start": 106.68, "end": 107.02, "word": " home.", "probability": 0.88330078125}, {"start": 107.18, "end": 107.36, "word": " He", "probability": 0.833984375}, {"start": 107.36, "end": 107.68, "word": " wants", "probability": 0.85205078125}, {"start": 107.68, "end": 108.04, "word": " what?", "probability": 0.80908203125}, {"start": 109.26, "end": 109.7, "word": " He", "probability": 0.497802734375}, {"start": 109.7, "end": 110.08, "word": " wants", "probability": 0.84130859375}, {"start": 110.08, "end": 110.36, "word": " what?", "probability": 0.68017578125}, {"start": 110.76, "end": 111.32, "word": " To", "probability": 0.8740234375}, {"start": 111.32, "end": 111.56, "word": " go", "probability": 0.96630859375}, {"start": 111.56, "end": 111.88, "word": " home.", "probability": 0.87890625}, {"start": 112.16, "end": 112.3, "word": " He", "probability": 0.73291015625}, {"start": 112.3, "end": 112.68, "word": " wants", "probability": 0.83740234375}, {"start": 112.68, "end": 112.86, "word": " to", "probability": 0.9697265625}, {"start": 112.86, "end": 113.04, "word": " go", "probability": 0.96533203125}, {"start": 113.04, "end": 113.36, "word": " home.", "probability": 0.8837890625}, {"start": 113.58, "end": 113.92, "word": " Where", "probability": 0.82080078125}, {"start": 113.92, "end": 114.06, "word": " is", "probability": 0.92431640625}, {"start": 114.06, "end": 114.18, "word": " the", "probability": 0.9140625}, {"start": 114.18, "end": 114.48, "word": " object?", "probability": 0.95556640625}], "temperature": 1.0}, {"id": 5, "seek": 14572, "start": 117.35, "end": 145.73, "text": " Now listen. The object is usually an answer to what? I ate an apple. What did I eat? I saw a film. What did I see? I read a book. What did I read? So the object is usually an answer to what? He wants what? To go home. Thank you. So where is the object again? To go home. The object is always a noun.", "tokens": [823, 2140, 13, 440, 2657, 307, 2673, 364, 1867, 281, 437, 30, 286, 8468, 364, 10606, 13, 708, 630, 286, 1862, 30, 286, 1866, 257, 2007, 13, 708, 630, 286, 536, 30, 286, 1401, 257, 1446, 13, 708, 630, 286, 1401, 30, 407, 264, 2657, 307, 2673, 364, 1867, 281, 437, 30, 634, 2738, 437, 30, 1407, 352, 1280, 13, 1044, 291, 13, 407, 689, 307, 264, 2657, 797, 30, 1407, 352, 1280, 13, 440, 2657, 307, 1009, 257, 23307, 13], "avg_logprob": -0.11099466563361447, "compression_ratio": 1.875, "no_speech_prob": 0.0, "words": [{"start": 117.35, "end": 117.91, "word": " Now", "probability": 0.57177734375}, {"start": 117.91, "end": 118.35, "word": " listen.", "probability": 0.83056640625}, {"start": 119.17, "end": 119.73, "word": " The", "probability": 0.80810546875}, {"start": 119.73, "end": 120.29, "word": " object", "probability": 0.95849609375}, {"start": 120.29, "end": 120.79, "word": " is", "probability": 0.939453125}, {"start": 120.79, "end": 121.29, 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The object is always a noun. You remember when we talked about the adjective phrases and the adverb phrases, we said,", "tokens": [1779, 30, 440, 2657, 307, 1009, 257, 23307, 13, 509, 1604, 562, 321, 2825, 466, 264, 44129, 20312, 293, 264, 614, 25809, 20312, 11, 321, 848, 11], "avg_logprob": -0.21665737298982485, "compression_ratio": 1.2019230769230769, "no_speech_prob": 0.0, "words": [{"start": 146.83999999999997, "end": 147.48, "word": " Right?", "probability": 0.63232421875}, {"start": 148.22, "end": 148.48, "word": " The", "probability": 0.8056640625}, {"start": 148.48, "end": 148.92, "word": " object", "probability": 0.93408203125}, {"start": 148.92, "end": 149.22, "word": " is", "probability": 0.9326171875}, {"start": 149.22, "end": 149.7, "word": " always", "probability": 0.9052734375}, {"start": 149.7, "end": 149.9, "word": " a", "probability": 0.958984375}, {"start": 149.9, "end": 150.12, "word": " noun.", "probability": 0.91943359375}, {"start": 151.52, "end": 151.76, "word": " You", "probability": 0.75439453125}, {"start": 151.76, "end": 152.24, "word": " remember", "probability": 0.87744140625}, {"start": 152.24, "end": 152.8, "word": " when", "probability": 0.60009765625}, {"start": 152.8, "end": 153.02, "word": " we", "probability": 0.9638671875}, {"start": 153.02, "end": 153.34, "word": " talked", "probability": 0.86572265625}, {"start": 153.34, "end": 153.66, "word": " about", "probability": 0.93603515625}, {"start": 153.66, "end": 153.82, "word": " the", "probability": 0.60498046875}, {"start": 153.82, "end": 154.24, "word": " adjective", "probability": 0.81640625}, {"start": 154.24, "end": 154.9, "word": " phrases", "probability": 0.8486328125}, {"start": 154.9, "end": 155.2, "word": " and", "probability": 0.90673828125}, {"start": 155.2, "end": 155.46, "word": " the", "probability": 0.62548828125}, {"start": 155.46, "end": 155.96, "word": " adverb", "probability": 0.9267578125}, {"start": 155.96, "end": 156.5, "word": " phrases,", "probability": 0.85986328125}, {"start": 156.62, "end": 156.76, "word": " we", "probability": 0.94189453125}, {"start": 156.76, "end": 157.14, "word": " said,", "probability": 0.93896484375}], "temperature": 1.0}, {"id": 7, "seek": 18591, "start": 157.95, "end": 185.91, "text": " It is an adjective phrase because it acts, it behaves as an adjective. It is an adverb phrase because it behaves as an adverb. But this noun phrase is used as the noun, as the object. The object is the noun. So now it is the noun. It is the object. So the phrase itself is the object. Look at the other sentence. 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I tried what? To get the sum right. Okay, thank you. So where is the object, Naveen? To get the sum right. Thank you very much. Read the other one, Hanin. To win a prize is my ambition. Good. Now where is the subject? When I say this is my ambition, where is the subject? 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Just a minute. Wait, please give her a chance. Where is the subject? Answer my question. Very good. This is the subject. And the subject is a phrase. It is a noun phrase. Very good. So, can you tell me what is a noun phrase? 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It is the subject or the object, okay? And the subjects and the objects are usually nouns. Are always nouns. We cannot use other words as subjects or as objects. They are usually nouns. So, a noun phrase is used as the object or as the subject of the sentence. 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Now, look at this exercise. Number one, Noor, can you read? Pick out the noun phrases in the following sentences. Yes, where are the noun phrases? Good. His father wished to speak to the headmaster. His father wished. Yes, where is the phrase? To speak. To speak. Listen, just a minute. His father wished what? What? 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What prefer living in? Yes, prefer what? Living in dark stables. Good. Now, these are the answers. You can look at them. 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The preposition phrase is made at least of two words. Two words, a preposition and another word. This word can be a noun, can be a pronoun, can be a gerund, or", "tokens": [823, 11, 321, 2825, 466, 264, 44129, 9535, 11, 264, 614, 25809, 9535, 11, 293, 264, 23307, 9535, 13, 440, 2666, 5830, 9535, 307, 1027, 412, 1935, 295, 732, 2283, 13, 4453, 2283, 11, 257, 2666, 5830, 293, 1071, 1349, 13, 639, 1349, 393, 312, 257, 23307, 11, 393, 312, 257, 14144, 11, 393, 312, 257, 5713, 997, 11, 420], "avg_logprob": -0.13960040495043896, "compression_ratio": 1.7234042553191489, "no_speech_prob": 0.0, "words": [{"start": 373.64, "end": 373.88, "word": " Now,", "probability": 0.89892578125}, {"start": 373.98, "end": 374.08, "word": " we", "probability": 0.96337890625}, {"start": 374.08, "end": 374.38, "word": " talked", "probability": 0.83837890625}, {"start": 374.38, "end": 374.82, "word": " about", "probability": 0.91015625}, {"start": 374.82, "end": 375.82, "word": " the", "probability": 0.86865234375}, {"start": 375.82, "end": 376.2, "word": " adjective", "probability": 0.880859375}, {"start": 376.2, "end": 376.8, "word": " phrase,", "probability": 0.82861328125}, {"start": 377.1, "end": 377.7, "word": " the", "probability": 0.87548828125}, {"start": 377.7, "end": 378.06, "word": " adverb", "probability": 0.931884765625}, {"start": 378.06, "end": 378.64, "word": " phrase,", "probability": 0.8857421875}, {"start": 378.76, "end": 379.42, "word": " and", "probability": 0.93408203125}, {"start": 379.42, "end": 379.56, "word": " the", "probability": 0.8095703125}, {"start": 379.56, "end": 379.76, "word": " noun", "probability": 0.9599609375}, {"start": 379.76, "end": 380.22, "word": " phrase.", "probability": 0.8486328125}, {"start": 381.14, "end": 381.4, "word": " The", "probability": 0.86181640625}, {"start": 381.4, "end": 382.04, "word": " preposition", "probability": 0.9306640625}, {"start": 382.04, "end": 382.74, "word": " phrase", "probability": 0.8759765625}, {"start": 382.74, "end": 383.62, "word": " is", "probability": 0.94140625}, {"start": 383.62, "end": 383.94, "word": " made", "probability": 0.86572265625}, {"start": 383.94, "end": 384.26, "word": " at", "probability": 0.77978515625}, {"start": 384.26, "end": 384.64, "word": " least", "probability": 0.95751953125}, {"start": 384.64, "end": 384.88, "word": " of", "probability": 0.96435546875}, {"start": 384.88, "end": 385.12, "word": " two", "probability": 0.92919921875}, {"start": 385.12, "end": 385.54, "word": " words.", "probability": 0.8642578125}, {"start": 386.88, "end": 387.48, "word": " Two", "probability": 0.83984375}, {"start": 387.48, "end": 387.92, "word": " words,", "probability": 0.8681640625}, {"start": 388.82, "end": 389.14, "word": " a", "probability": 0.9814453125}, {"start": 389.14, "end": 389.62, "word": " preposition", "probability": 0.9775390625}, {"start": 389.62, "end": 390.2, "word": " and", "probability": 0.7392578125}, {"start": 390.2, "end": 390.72, "word": " another", "probability": 0.92529296875}, {"start": 390.72, "end": 391.24, "word": " word.", "probability": 0.93798828125}, {"start": 392.4, "end": 392.72, "word": " This", "probability": 0.88623046875}, {"start": 392.72, "end": 393.12, "word": " word", "probability": 0.93310546875}, {"start": 393.12, "end": 393.8, "word": " can", "probability": 0.92822265625}, {"start": 393.8, "end": 393.98, "word": " be", "probability": 0.95556640625}, {"start": 393.98, "end": 394.14, "word": " a", "probability": 0.966796875}, {"start": 394.14, "end": 394.4, "word": " noun,", "probability": 0.974609375}, {"start": 395.6, "end": 395.78, "word": " can", "probability": 0.81005859375}, {"start": 395.78, "end": 395.98, "word": " be", "probability": 0.9560546875}, {"start": 395.98, "end": 396.18, "word": " a", "probability": 0.9921875}, {"start": 396.18, "end": 396.42, "word": " pronoun,", "probability": 0.97021484375}, {"start": 396.92, "end": 397.8, "word": " can", "probability": 0.89306640625}, {"start": 397.8, "end": 398.02, "word": " be", "probability": 0.9560546875}, {"start": 398.02, "end": 398.22, "word": " a", "probability": 0.97265625}, {"start": 398.22, "end": 398.62, "word": " gerund,", "probability": 0.983642578125}, {"start": 398.9, "end": 399.66, "word": " or", "probability": 0.9677734375}], "temperature": 1.0}, {"id": 16, "seek": 42467, "start": 400.81, "end": 424.67, "text": " A noun clause. How? Now let's see. If you look at this example, when I say at home, I have preposition and noun. In time, preposition and noun. Okay, from Sue. Preposition and noun. With me. 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Okay, by singing, by sleeping, by eating. Okay, this is gerund. Now, as you see, they are prepositional phrases. They are made of a preposition and a noun, a pronoun or a gerund. Now, look about what we need.", "tokens": [21684, 5830, 293, 30, 1033, 11, 538, 6726, 11, 538, 8296, 11, 538, 3936, 13, 1033, 11, 341, 307, 5713, 997, 13, 823, 11, 382, 291, 536, 11, 436, 366, 2666, 329, 2628, 20312, 13, 814, 366, 1027, 295, 257, 2666, 5830, 293, 257, 23307, 11, 257, 14144, 420, 257, 5713, 997, 13, 823, 11, 574, 466, 437, 321, 643, 13], "avg_logprob": -0.15965222351012692, "compression_ratio": 1.6028368794326242, "no_speech_prob": 0.0, "words": [{"start": 426.29, "end": 426.93, "word": " Preposition", "probability": 0.65869140625}, {"start": 426.93, "end": 427.35, "word": " and?", "probability": 0.7607421875}, {"start": 428.07, "end": 428.31, "word": " Okay,", "probability": 0.54736328125}, {"start": 428.47, "end": 428.73, "word": " by", "probability": 0.92138671875}, {"start": 428.73, "end": 429.41, "word": " singing,", "probability": 0.935546875}, {"start": 430.45, "end": 431.01, "word": " by", "probability": 0.9345703125}, {"start": 431.01, "end": 431.73, "word": " sleeping,", "probability": 0.91845703125}, {"start": 432.45, "end": 433.25, "word": " by", "probability": 0.9638671875}, {"start": 433.25, "end": 433.87, "word": " eating.", "probability": 0.91455078125}, {"start": 434.63, "end": 434.97, "word": " Okay,", "probability": 0.7880859375}, {"start": 435.13, "end": 435.31, "word": " this", "probability": 0.943359375}, {"start": 435.31, "end": 435.51, "word": " is", "probability": 0.95556640625}, {"start": 435.51, "end": 435.89, "word": " gerund.", "probability": 0.933349609375}, {"start": 436.31, "end": 436.69, "word": " Now,", "probability": 0.94140625}, {"start": 436.77, "end": 437.01, "word": " as", "probability": 0.96337890625}, {"start": 437.01, "end": 437.17, "word": " you", "probability": 0.96728515625}, {"start": 437.17, "end": 437.51, "word": " see,", "probability": 0.92138671875}, {"start": 437.69, "end": 437.83, "word": " they", "probability": 0.77294921875}, {"start": 437.83, "end": 438.19, "word": " are", "probability": 0.93798828125}, {"start": 438.19, "end": 438.87, "word": " prepositional", "probability": 0.9373372395833334}, {"start": 438.87, "end": 439.47, "word": " phrases.", "probability": 0.83349609375}, {"start": 440.55, "end": 440.69, "word": " They", "probability": 0.83447265625}, {"start": 440.69, "end": 441.01, "word": " are", "probability": 0.94189453125}, {"start": 441.01, "end": 441.37, "word": " made", "probability": 0.875}, {"start": 441.37, "end": 441.75, "word": " of", "probability": 0.958984375}, {"start": 441.75, "end": 442.61, "word": " a", "probability": 0.97119140625}, {"start": 442.61, "end": 443.21, "word": " preposition", "probability": 0.9853515625}, {"start": 443.21, "end": 443.65, "word": " and", "probability": 0.8876953125}, {"start": 443.65, "end": 443.83, "word": " a", "probability": 0.9580078125}, {"start": 443.83, "end": 444.13, "word": " noun,", "probability": 0.95263671875}, {"start": 444.31, "end": 444.49, "word": " a", "probability": 0.96142578125}, {"start": 444.49, "end": 444.93, "word": " pronoun", "probability": 0.96533203125}, {"start": 444.93, "end": 445.43, "word": " or", "probability": 0.619140625}, {"start": 445.43, "end": 446.45, "word": " a", "probability": 0.953125}, {"start": 446.45, "end": 446.89, "word": " gerund.", "probability": 0.97802734375}, {"start": 447.45, "end": 447.73, "word": " Now,", "probability": 0.94921875}, {"start": 448.43, "end": 448.73, "word": " look", "probability": 0.96240234375}, {"start": 448.73, "end": 449.59, "word": " about", "probability": 0.5869140625}, {"start": 449.59, "end": 450.09, "word": " what", "probability": 0.93701171875}, {"start": 450.09, "end": 450.29, "word": " we", "probability": 0.94140625}, {"start": 450.29, "end": 450.75, "word": " need.", "probability": 0.93505859375}], "temperature": 1.0}, {"id": 18, "seek": 47821, "start": 452.11, "end": 478.21, "text": " about what we need. We have a preposition and a noun clause. What is the noun clause? Just wait, we are going to talk about it. Now, from my grandfather, from my grandmother, this is a preposition and this is a modifier.", "tokens": [466, 437, 321, 643, 13, 492, 362, 257, 2666, 5830, 293, 257, 23641, 77, 25925, 13, 708, 307, 264, 23307, 25925, 30, 1449, 1699, 11, 321, 366, 516, 281, 751, 466, 309, 13, 823, 11, 490, 452, 14754, 11, 490, 452, 14317, 11, 341, 307, 257, 2666, 5830, 293, 341, 307, 257, 38011, 13], "avg_logprob": -0.18025568181818183, "compression_ratio": 1.5785714285714285, "no_speech_prob": 0.0, "words": [{"start": 452.11, "end": 452.63, "word": " about", "probability": 0.67724609375}, {"start": 452.63, "end": 453.03, "word": " what", "probability": 0.939453125}, {"start": 453.03, "end": 453.23, "word": " we", "probability": 0.95849609375}, {"start": 453.23, "end": 453.49, "word": " need.", "probability": 0.92578125}, {"start": 453.59, "end": 453.67, "word": " We", "probability": 0.93310546875}, {"start": 453.67, "end": 453.97, "word": " have", "probability": 0.9453125}, {"start": 453.97, "end": 454.17, "word": " a", "probability": 0.974609375}, {"start": 454.17, "end": 454.63, "word": " preposition", "probability": 0.968994140625}, {"start": 454.63, "end": 455.49, "word": " and", "probability": 0.900390625}, {"start": 455.49, "end": 456.43, "word": " a", "probability": 0.80029296875}, {"start": 456.43, "end": 456.59, "word": " noun", "probability": 0.65380859375}, {"start": 456.59, "end": 457.11, "word": " clause.", "probability": 0.83544921875}, {"start": 458.25, "end": 459.05, "word": " What", "probability": 0.38232421875}, {"start": 459.05, "end": 459.29, "word": " is", "probability": 0.93505859375}, {"start": 459.29, "end": 459.47, "word": " the", "probability": 0.84033203125}, {"start": 459.47, "end": 459.65, "word": " noun", "probability": 0.962890625}, {"start": 459.65, "end": 460.07, "word": " clause?", "probability": 0.87255859375}, {"start": 460.67, "end": 460.97, "word": " Just", "probability": 0.71142578125}, {"start": 460.97, "end": 461.29, "word": " wait,", "probability": 0.85986328125}, {"start": 461.45, "end": 461.55, "word": " we", "probability": 0.953125}, {"start": 461.55, "end": 462.71, "word": " are", "probability": 0.59716796875}, {"start": 462.71, "end": 463.03, "word": " going", "probability": 0.94384765625}, {"start": 463.03, "end": 463.21, "word": " to", "probability": 0.97119140625}, {"start": 463.21, "end": 463.45, "word": " talk", "probability": 0.88330078125}, {"start": 463.45, "end": 463.77, "word": " about", "probability": 0.9013671875}, {"start": 463.77, "end": 464.03, "word": " it.", "probability": 0.943359375}, {"start": 466.21, "end": 467.01, "word": " Now,", "probability": 0.465576171875}, {"start": 469.19, "end": 469.59, "word": " from", "probability": 0.79150390625}, {"start": 469.59, "end": 470.03, "word": " my", "probability": 0.966796875}, {"start": 470.03, "end": 471.13, "word": " grandfather,", "probability": 0.869140625}, {"start": 471.67, "end": 472.15, "word": " from", "probability": 0.8037109375}, {"start": 472.15, "end": 472.57, "word": " my", "probability": 0.9736328125}, {"start": 472.57, "end": 473.55, "word": " grandmother,", "probability": 0.810546875}, {"start": 474.51, "end": 475.05, "word": " this", "probability": 0.9140625}, {"start": 475.05, "end": 475.23, "word": " is", "probability": 0.94873046875}, {"start": 475.23, "end": 475.41, "word": " a", "probability": 0.99072265625}, {"start": 475.41, "end": 475.95, "word": " preposition", "probability": 0.975830078125}, {"start": 475.95, "end": 476.89, "word": " and", "probability": 0.58935546875}, {"start": 476.89, "end": 477.15, "word": " this", "probability": 0.94287109375}, {"start": 477.15, "end": 477.39, "word": " is", "probability": 0.94482421875}, {"start": 477.39, "end": 477.71, "word": " a", "probability": 0.99560546875}, {"start": 477.71, "end": 478.21, "word": " modifier.", "probability": 0.97705078125}], "temperature": 1.0}, {"id": 19, "seek": 50868, "start": 479.5, "end": 508.68, "text": " A modifier is a specifier. It specifies the noun. When I say grandmother, it can be any grandmother. When I say your grandmother, it's that. Okay. My grandmother, it made the noun specific. So, we use what? A preposition, a modifier, and a noun. Under the warm blanket.", "tokens": [316, 38011, 307, 257, 1608, 9902, 13, 467, 1608, 11221, 264, 23307, 13, 1133, 286, 584, 14317, 11, 309, 393, 312, 604, 14317, 13, 1133, 286, 584, 428, 14317, 11, 309, 311, 300, 13, 1033, 13, 1222, 14317, 11, 309, 1027, 264, 23307, 2685, 13, 407, 11, 321, 764, 437, 30, 316, 2666, 5830, 11, 257, 38011, 11, 293, 257, 23307, 13, 6974, 264, 4561, 17907, 13], "avg_logprob": -0.16417738576145732, "compression_ratio": 1.6875, "no_speech_prob": 0.0, "words": [{"start": 479.5, "end": 479.78, "word": " A", "probability": 0.80810546875}, {"start": 479.78, "end": 480.16, "word": " modifier", "probability": 0.9384765625}, {"start": 480.16, "end": 481.24, "word": " is", "probability": 0.95263671875}, {"start": 481.24, "end": 481.78, "word": " a", "probability": 0.99609375}, {"start": 481.78, "end": 482.4, "word": " specifier.", "probability": 0.958984375}, {"start": 483.4, "end": 483.9, "word": " It", "probability": 0.95166015625}, {"start": 483.9, "end": 484.76, 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It can be expanded. We can use also modifiers in a noun, in a prepositional phrase. A prepositional phrase usually behaves as an adjective or as an adverb.", "tokens": [316, 23307, 11, 257, 14144, 420, 5713, 997, 420, 257, 23307, 25925, 13, 467, 393, 312, 14342, 13, 492, 393, 764, 611, 1072, 23463, 294, 257, 23307, 11, 294, 257, 2666, 329, 2628, 9535, 13, 316, 2666, 329, 2628, 9535, 2673, 36896, 382, 364, 44129, 420, 382, 364, 614, 25809, 13], "avg_logprob": -0.19681489668213403, "compression_ratio": 1.507462686567164, "no_speech_prob": 0.0, "words": [{"start": 530.28, "end": 530.8, "word": " A", "probability": 0.376708984375}, {"start": 530.8, "end": 531.3, "word": " noun,", "probability": 0.80322265625}, {"start": 532.06, "end": 532.48, "word": " a", "probability": 0.8662109375}, {"start": 532.48, "end": 532.8, "word": " pronoun", "probability": 0.9677734375}, {"start": 532.8, "end": 533.48, "word": " or", "probability": 0.459716796875}, {"start": 533.48, "end": 534.6, "word": " gerund", "probability": 0.737548828125}, {"start": 534.6, "end": 535.1, "word": " or", "probability": 0.62890625}, {"start": 535.1, "end": 535.14, "word": " a", "probability": 0.76953125}, {"start": 535.14, "end": 536.2, "word": " noun", "probability": 0.60498046875}, {"start": 536.2, "end": 536.72, "word": " clause.", "probability": 0.7353515625}, {"start": 536.86, "end": 537.0, "word": " It", "probability": 0.8994140625}, {"start": 537.0, "end": 537.26, "word": " can", "probability": 0.94970703125}, {"start": 537.26, "end": 537.46, "word": " be", "probability": 0.94873046875}, {"start": 537.46, "end": 538.06, "word": " expanded.", "probability": 0.84423828125}, {"start": 538.52, "end": 538.66, "word": " We", "probability": 0.93994140625}, {"start": 538.66, "end": 538.96, "word": " can", "probability": 0.9443359375}, {"start": 538.96, "end": 539.22, "word": " use", "probability": 0.72412109375}, {"start": 539.22, "end": 539.6, "word": " also", "probability": 0.83056640625}, {"start": 539.6, "end": 540.22, "word": " modifiers", "probability": 0.895751953125}, {"start": 540.22, "end": 540.46, "word": " in", "probability": 0.95166015625}, {"start": 540.46, "end": 540.64, "word": " a", "probability": 0.984375}, {"start": 540.64, "end": 540.9, "word": " noun,", "probability": 0.93994140625}, {"start": 541.44, "end": 541.66, "word": " in", "probability": 0.92138671875}, {"start": 541.66, "end": 541.8, "word": " a", "probability": 0.95263671875}, {"start": 541.8, "end": 542.44, "word": " prepositional", "probability": 0.9348958333333334}, {"start": 542.44, "end": 543.0, "word": " phrase.", "probability": 0.86572265625}, {"start": 543.28, "end": 543.86, "word": " A", "probability": 0.6904296875}, {"start": 543.86, "end": 544.52, "word": " prepositional", "probability": 0.9501953125}, {"start": 544.52, "end": 545.16, "word": " phrase", "probability": 0.88427734375}, {"start": 545.16, "end": 546.44, "word": " usually", "probability": 0.80517578125}, {"start": 546.44, "end": 548.32, "word": " behaves", "probability": 0.87890625}, {"start": 548.32, "end": 548.84, "word": " as", "probability": 0.966796875}, {"start": 548.84, "end": 549.22, "word": " an", "probability": 0.94921875}, {"start": 549.22, "end": 549.86, "word": " adjective", "probability": 0.947265625}, {"start": 549.86, "end": 551.2, "word": " or", "probability": 0.93408203125}, {"start": 551.2, "end": 551.48, "word": " as", "probability": 0.89306640625}, {"start": 551.48, "end": 551.76, "word": " an", "probability": 0.96044921875}, {"start": 551.76, "end": 552.16, "word": " adverb.", "probability": 0.963623046875}], "temperature": 1.0}, {"id": 22, "seek": 57717, "start": 552.86, "end": 577.18, "text": " Okay? So it functions usually as what? An adjective or an adverb. How can I distinguish between this and that? If you look at this example. Yeah, who wants to read the example? Yes, please. The book on the bathroom floor is stolen from a shower stand. Thank you. Now, the book on which one?", "tokens": [1033, 30, 407, 309, 6828, 2673, 382, 437, 30, 1107, 44129, 420, 364, 614, 25809, 13, 1012, 393, 286, 20206, 1296, 341, 293, 300, 30, 759, 291, 574, 412, 341, 1365, 13, 865, 11, 567, 2738, 281, 1401, 264, 1365, 30, 1079, 11, 1767, 13, 440, 1446, 322, 264, 8687, 4123, 307, 15900, 490, 257, 10128, 1463, 13, 1044, 291, 13, 823, 11, 264, 1446, 322, 597, 472, 30], "avg_logprob": -0.2084821445601327, "compression_ratio": 1.4846938775510203, "no_speech_prob": 0.0, "words": [{"start": 552.86, "end": 553.26, "word": " Okay?", "probability": 0.712890625}, {"start": 553.96, "end": 554.32, "word": " So", "probability": 0.921875}, {"start": 554.32, "end": 554.52, "word": " it", "probability": 0.7568359375}, {"start": 554.52, "end": 555.16, "word": " functions", "probability": 0.857421875}, {"start": 555.16, "end": 555.74, "word": " usually", "probability": 0.83056640625}, {"start": 555.74, "end": 556.16, "word": " as", "probability": 0.95751953125}, {"start": 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"text": " which one so it answers the question which one if it answers the question which one it is an adjective phrase okay it functions as an adjective phrase okay so a prepositional phrase when answers the question which one it functions as", "tokens": [597, 472, 370, 309, 6338, 264, 1168, 597, 472, 498, 309, 6338, 264, 1168, 597, 472, 309, 307, 364, 44129, 9535, 1392, 309, 6828, 382, 364, 44129, 9535, 1392, 370, 257, 2666, 329, 2628, 9535, 562, 6338, 264, 1168, 597, 472, 309, 6828, 382], "avg_logprob": -0.14522569709353977, "compression_ratio": 2.2718446601941746, "no_speech_prob": 4.172325134277344e-07, "words": [{"start": 578.52, "end": 578.92, "word": " which", "probability": 0.1678466796875}, {"start": 578.92, "end": 579.32, "word": " one", "probability": 0.943359375}, {"start": 579.32, "end": 580.6, "word": " so", "probability": 0.2205810546875}, {"start": 580.6, "end": 580.98, "word": " it", "probability": 0.9638671875}, {"start": 580.98, "end": 581.58, "word": " answers", 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Good. Now which book? Now look at the other one. Who can read the example? Yes Khadija. The sweet potatoes in the vegetable bin are green with mold. Okay, which ones?", "tokens": [1107, 44129, 9535, 13, 2205, 13, 823, 597, 1446, 30, 823, 574, 412, 264, 661, 472, 13, 2102, 393, 1401, 264, 1365, 30, 1079, 11681, 345, 20642, 13, 440, 3844, 11811, 294, 264, 16356, 5171, 366, 3092, 365, 11102, 13, 1033, 11, 597, 2306, 30], "avg_logprob": -0.2657948434352875, "compression_ratio": 1.2876712328767124, "no_speech_prob": 0.0, "words": [{"start": 599.88, "end": 600.36, "word": " An", "probability": 0.32763671875}, {"start": 600.36, "end": 600.84, "word": " adjective", "probability": 0.85986328125}, {"start": 600.84, "end": 601.44, "word": " phrase.", "probability": 0.75830078125}, {"start": 601.86, "end": 602.04, "word": " Good.", "probability": 0.75341796875}, {"start": 602.62, "end": 602.8, "word": " Now", "probability": 0.900390625}, {"start": 602.8, "end": 603.1, "word": " which", "probability": 0.484619140625}, {"start": 603.1, "end": 603.42, "word": " book?", "probability": 0.9482421875}, {"start": 603.54, "end": 603.68, "word": " Now", "probability": 0.8095703125}, {"start": 603.68, "end": 603.92, "word": " look", "probability": 0.88232421875}, {"start": 603.92, "end": 604.08, "word": " at", "probability": 0.96875}, {"start": 604.08, "end": 604.2, "word": " the", "probability": 0.919921875}, {"start": 604.2, "end": 604.42, "word": " other", "probability": 0.89892578125}, {"start": 604.42, "end": 604.7, "word": " one.", "probability": 0.89697265625}, {"start": 604.78, "end": 604.86, "word": " Who", "probability": 0.8408203125}, {"start": 604.86, "end": 605.14, "word": " can", "probability": 0.943359375}, {"start": 605.14, "end": 605.32, "word": " read", "probability": 0.9765625}, {"start": 605.32, "end": 605.46, "word": " the", "probability": 0.89111328125}, {"start": 605.46, "end": 605.84, "word": " example?", "probability": 0.96728515625}, {"start": 606.06, "end": 606.24, "word": " Yes", "probability": 0.892578125}, {"start": 606.24, "end": 606.92, "word": " Khadija.", "probability": 0.8001302083333334}, {"start": 607.2, "end": 607.34, "word": " The", "probability": 0.3837890625}, {"start": 607.34, "end": 607.62, "word": " sweet", "probability": 0.86279296875}, {"start": 607.62, "end": 608.06, "word": " potatoes", "probability": 0.88525390625}, {"start": 608.06, "end": 608.42, "word": " in", "probability": 0.83251953125}, {"start": 608.42, "end": 608.7, "word": " the", "probability": 0.89501953125}, {"start": 608.7, "end": 609.16, "word": " vegetable", "probability": 0.9375}, {"start": 609.16, "end": 609.48, "word": " bin", "probability": 0.4892578125}, {"start": 609.48, "end": 609.72, "word": " are", "probability": 0.900390625}, {"start": 609.72, "end": 610.04, "word": " green", "probability": 0.935546875}, {"start": 610.04, "end": 610.26, "word": " with", "probability": 0.85302734375}, {"start": 610.26, "end": 610.48, "word": " mold.", "probability": 0.27978515625}, {"start": 610.58, "end": 610.82, "word": " Okay,", "probability": 0.73974609375}, {"start": 610.98, "end": 611.16, "word": " which", "probability": 0.94384765625}, {"start": 611.16, "end": 611.66, "word": " ones?", "probability": 0.8955078125}], "temperature": 1.0}, {"id": 25, "seek": 64129, "start": 612.63, "end": 641.29, "text": " Which ones? So, this prepositional phrase functions as what? An adjective phrase. Now, what about the prepositional phrase when it functions as an adverb? When it functions as an adverb, you know, adverb phrases and clauses usually answer questions like what, like why, how, when, where, okay?", "tokens": [3013, 2306, 30, 407, 11, 341, 2666, 329, 2628, 9535, 6828, 382, 437, 30, 1107, 44129, 9535, 13, 823, 11, 437, 466, 264, 2666, 329, 2628, 9535, 562, 309, 6828, 382, 364, 614, 25809, 30, 1133, 309, 6828, 382, 364, 614, 25809, 11, 291, 458, 11, 614, 25809, 20312, 293, 49072, 2673, 1867, 1651, 411, 437, 11, 411, 983, 11, 577, 11, 562, 11, 689, 11, 1392, 30], "avg_logprob": -0.16043931591338007, "compression_ratio": 1.7818181818181817, "no_speech_prob": 0.0, "words": [{"start": 612.63, "end": 612.99, "word": " Which", "probability": 0.56396484375}, {"start": 612.99, "end": 613.33, "word": " ones?", "probability": 0.83984375}, {"start": 613.99, "end": 614.79, "word": " So,", "probability": 0.81103515625}, {"start": 615.19, "end": 615.49, "word": " this", "probability": 0.9287109375}, {"start": 615.49, "end": 616.71, "word": " prepositional", "probability": 0.9021809895833334}, {"start": 616.71, "end": 617.23, "word": " phrase", "probability": 0.884765625}, {"start": 617.23, "end": 617.77, "word": " functions", "probability": 0.8837890625}, {"start": 617.77, "end": 618.21, "word": " as", "probability": 0.96630859375}, {"start": 618.21, "end": 618.55, "word": " what?", "probability": 0.890625}, {"start": 618.75, "end": 619.51, "word": " An", "probability": 0.837890625}, {"start": 619.51, "end": 619.95, "word": " adjective", "probability": 0.84130859375}, {"start": 619.95, "end": 620.43, "word": " phrase.", "probability": 0.8095703125}, {"start": 620.79, "end": 620.99, "word": " Now,", "probability": 0.9169921875}, {"start": 621.11, "end": 621.23, "word": " what", "probability": 0.9306640625}, {"start": 621.23, "end": 621.73, "word": " about", "probability": 0.9130859375}, {"start": 621.73, "end": 622.11, "word": " the", "probability": 0.88671875}, {"start": 622.11, "end": 623.57, "word": " prepositional", "probability": 0.7864583333333334}, {"start": 623.57, "end": 624.13, "word": " phrase", "probability": 0.8408203125}, {"start": 624.13, "end": 624.41, "word": " when", "probability": 0.86376953125}, {"start": 624.41, "end": 624.59, "word": " it", "probability": 0.95556640625}, {"start": 624.59, "end": 625.09, "word": " functions", "probability": 0.89306640625}, {"start": 625.09, "end": 625.47, "word": " as", "probability": 0.96533203125}, {"start": 625.47, "end": 625.77, "word": " an", "probability": 0.94580078125}, {"start": 625.77, "end": 626.17, "word": " adverb?", "probability": 0.956298828125}, {"start": 626.87, "end": 627.17, "word": " When", "probability": 0.81689453125}, {"start": 627.17, "end": 627.33, "word": " it", "probability": 0.9560546875}, {"start": 627.33, "end": 627.79, "word": " functions", "probability": 0.89013671875}, {"start": 627.79, "end": 628.17, "word": " as", "probability": 0.9638671875}, {"start": 628.17, "end": 628.87, "word": " an", "probability": 0.86279296875}, {"start": 628.87, "end": 629.35, "word": " adverb,", "probability": 0.971923828125}, {"start": 629.49, "end": 629.57, "word": " you", "probability": 0.953125}, {"start": 629.57, "end": 629.85, "word": " know,", "probability": 0.89697265625}, {"start": 630.95, "end": 631.35, "word": " adverb", "probability": 0.904296875}, {"start": 631.35, "end": 631.91, "word": " phrases", "probability": 0.8916015625}, {"start": 631.91, "end": 632.59, "word": " and", "probability": 0.91845703125}, {"start": 632.59, "end": 633.15, "word": " clauses", "probability": 0.9326171875}, {"start": 633.15, "end": 633.91, "word": " usually", "probability": 0.86572265625}, {"start": 633.91, "end": 634.45, "word": " answer", "probability": 0.92626953125}, {"start": 634.45, "end": 635.09, "word": " questions", "probability": 0.84765625}, {"start": 635.09, "end": 635.47, "word": " like", "probability": 0.9267578125}, {"start": 635.47, "end": 635.87, "word": " what,", "probability": 0.7109375}, {"start": 636.51, "end": 637.71, "word": " like", "probability": 0.6767578125}, {"start": 637.71, "end": 638.15, "word": " why,", "probability": 0.90625}, {"start": 638.39, "end": 638.85, "word": " how,", "probability": 0.92236328125}, {"start": 639.21, "end": 639.83, "word": " when,", "probability": 0.95166015625}, {"start": 640.11, "end": 640.55, "word": " where,", "probability": 0.93896484375}, {"start": 640.85, "end": 641.29, "word": " okay?", "probability": 0.85400390625}], "temperature": 1.0}, {"id": 26, "seek": 66923, "start": 641.91, "end": 669.23, "text": " Now, Fadi. Yeah, who wants to read the example? Hanin. Okay, Fadi is stiff from yesterday's long football practice. Thank you. How did he get stiff? So it answers what? How? It answers how? So it functions as? Adverb. Very good. Read the other one, please. 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Before class. Okay, so before class, this is a prepositional phrase, it acts or functions as? Thank you. And finally, finally, yes please read.", "tokens": [1033, 11, 562, 630, 508, 43837, 360, 341, 30, 4546, 1508, 13, 1033, 11, 370, 949, 1508, 11, 341, 307, 257, 2666, 329, 2628, 9535, 11, 309, 10672, 420, 6828, 382, 30, 1044, 291, 13, 400, 2721, 11, 2721, 11, 2086, 1767, 1401, 13], "avg_logprob": -0.2965277645323012, "compression_ratio": 1.3384615384615384, "no_speech_prob": 0.0, "words": [{"start": 675.1299999999999, "end": 675.9699999999999, "word": " Okay,", "probability": 0.1981201171875}, {"start": 675.9699999999999, "end": 676.81, "word": " when", "probability": 0.82958984375}, {"start": 676.81, "end": 677.05, "word": " did", "probability": 0.939453125}, {"start": 677.05, "end": 677.59, "word": " Jihad", "probability": 0.633056640625}, {"start": 677.59, "end": 678.03, "word": " do", "probability": 0.94873046875}, {"start": 678.03, "end": 678.55, "word": " this?", "probability": 0.953125}, {"start": 678.73, "end": 679.15, "word": " Before", "probability": 0.830078125}, {"start": 679.15, "end": 680.65, "word": " class.", "probability": 0.71044921875}, {"start": 680.99, "end": 681.13, "word": " Okay,", "probability": 0.56982421875}, {"start": 681.65, "end": 681.79, "word": " so", "probability": 0.8857421875}, {"start": 681.79, "end": 682.17, "word": " before", "probability": 0.76953125}, {"start": 682.17, "end": 682.77, "word": " class,", "probability": 0.880859375}, {"start": 682.89, "end": 683.03, "word": " this", "probability": 0.94482421875}, {"start": 683.03, "end": 683.17, "word": " is", "probability": 0.95751953125}, {"start": 683.17, "end": 683.31, "word": " a", "probability": 0.96875}, {"start": 683.31, "end": 684.05, "word": " prepositional", "probability": 0.9402669270833334}, {"start": 684.05, "end": 686.15, "word": " phrase,", "probability": 0.6748046875}, {"start": 686.19, "end": 687.25, "word": " it", "probability": 0.91015625}, {"start": 687.25, "end": 687.85, "word": " acts", "probability": 0.7734375}, {"start": 687.85, "end": 688.19, "word": " or", "probability": 0.91650390625}, {"start": 688.19, "end": 688.81, "word": " functions", "probability": 0.8720703125}, {"start": 688.81, "end": 689.47, "word": " as?", "probability": 0.96142578125}, {"start": 689.87, "end": 690.05, "word": " Thank", "probability": 0.38330078125}, {"start": 690.05, "end": 690.91, "word": " you.", "probability": 0.9619140625}, {"start": 691.43, "end": 691.75, "word": " And", "probability": 0.94580078125}, {"start": 691.75, "end": 692.47, "word": " finally,", "probability": 0.8330078125}, {"start": 693.03, "end": 693.59, "word": " finally,", "probability": 0.75830078125}, {"start": 693.69, "end": 693.87, "word": " yes", "probability": 0.9384765625}, {"start": 693.87, "end": 694.17, "word": " please", "probability": 0.59130859375}, {"start": 694.17, "end": 694.49, "word": " read.", "probability": 0.650390625}], "temperature": 1.0}, {"id": 28, "seek": 72207, "start": 701.69, "end": 722.07, "text": " Okay, where did we try the food? Okay. So again, this is what, what would you say about this point? Yes. What would you say? Okay. Thank you very much. Good. 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"start": 723.38, "end": 752.36, "text": " let's come to clauses okay so we talked about four types of phrases let's come to clauses first of all what is a clause we said a phrase is a group of related words without a verb without what type of verb finite verb and without", "tokens": [718, 311, 808, 281, 49072, 1392, 370, 321, 2825, 466, 1451, 3467, 295, 20312, 718, 311, 808, 281, 49072, 700, 295, 439, 437, 307, 257, 25925, 321, 848, 257, 9535, 307, 257, 1594, 295, 4077, 2283, 1553, 257, 9595, 1553, 437, 2010, 295, 9595, 19362, 9595, 293, 1553], "avg_logprob": -0.1525031936411955, "compression_ratio": 1.7293233082706767, "no_speech_prob": 0.0, "words": [{"start": 723.38, "end": 723.8, "word": " let's", "probability": 0.59051513671875}, {"start": 723.8, "end": 724.04, "word": " come", "probability": 0.8681640625}, {"start": 724.04, "end": 724.24, "word": " to", "probability": 0.9716796875}, {"start": 724.24, "end": 724.58, "word": " clauses", "probability": 0.92578125}, {"start": 724.58, 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So if this group of words contains a finite verb, has a subject and a predicate. First of all, what is the subject and what is the predicate? Who can give me a sentence? Give me a sentence.", "tokens": [1033, 11, 295, 1164, 11, 572, 9595, 11, 572, 3983, 11, 572, 3566, 2020, 13, 407, 498, 341, 1594, 295, 2283, 8306, 257, 19362, 9595, 11, 575, 257, 3983, 293, 257, 3852, 8700, 13, 2386, 295, 439, 11, 437, 307, 264, 3983, 293, 437, 307, 264, 3852, 8700, 30, 2102, 393, 976, 385, 257, 8174, 30, 5303, 385, 257, 8174, 13], "avg_logprob": -0.13356854309958796, "compression_ratio": 1.5833333333333333, "no_speech_prob": 0.0, "words": [{"start": 753.4, "end": 753.8, "word": " Okay,", "probability": 0.73974609375}, {"start": 753.92, "end": 754.08, "word": " of", "probability": 0.9521484375}, {"start": 754.08, "end": 754.4, "word": " course,", "probability": 0.9541015625}, {"start": 754.6, "end": 754.7, "word": " no", "probability": 0.8828125}, {"start": 754.7, "end": 755.04, "word": " verb,", "probability": 0.6943359375}, {"start": 755.16, "end": 755.32, "word": " no", "probability": 0.94775390625}, {"start": 755.32, "end": 755.8, "word": " subject,", "probability": 0.96533203125}, {"start": 756.24, "end": 756.4, "word": " no", "probability": 0.8857421875}, {"start": 756.4, "end": 757.34, "word": " complete", "probability": 0.755859375}, {"start": 757.34, "end": 757.78, "word": " sense.", "probability": 0.6767578125}, {"start": 758.56, "end": 758.76, "word": " So", "probability": 0.869140625}, {"start": 758.76, "end": 759.12, "word": " if", "probability": 0.58349609375}, {"start": 759.12, "end": 759.38, "word": " this", "probability": 0.9462890625}, {"start": 759.38, "end": 759.78, "word": " group", "probability": 0.95703125}, {"start": 759.78, "end": 760.06, "word": " of", "probability": 0.96337890625}, {"start": 760.06, "end": 760.38, "word": " words", "probability": 0.5576171875}, {"start": 760.38, "end": 761.96, "word": " contains", "probability": 0.8115234375}, {"start": 761.96, "end": 762.3, "word": " a", "probability": 0.9931640625}, {"start": 762.3, "end": 762.68, "word": " finite", "probability": 0.97314453125}, {"start": 762.68, "end": 763.16, "word": " verb,", "probability": 0.896484375}, {"start": 763.94, "end": 764.78, "word": " has", "probability": 0.900390625}, {"start": 764.78, "end": 765.02, "word": " a", "probability": 0.99658203125}, {"start": 765.02, "end": 765.38, "word": " subject", "probability": 0.96728515625}, {"start": 765.38, "end": 766.3, "word": " and", "probability": 0.73291015625}, {"start": 766.3, "end": 766.52, "word": " a", "probability": 0.97900390625}, {"start": 766.52, "end": 767.1, "word": " predicate.", "probability": 0.96728515625}, {"start": 767.56, "end": 768.0, "word": " First", "probability": 0.89794921875}, {"start": 768.0, "end": 768.2, "word": " of", "probability": 0.96875}, {"start": 768.2, "end": 768.42, "word": " all,", "probability": 0.94921875}, {"start": 768.54, "end": 768.7, "word": " what", "probability": 0.93896484375}, {"start": 768.7, "end": 768.86, "word": " is", "probability": 0.9375}, {"start": 768.86, "end": 769.04, "word": " the", "probability": 0.91455078125}, {"start": 769.04, "end": 769.34, "word": " subject", "probability": 0.96923828125}, {"start": 769.34, "end": 769.66, "word": " and", "probability": 0.85400390625}, {"start": 769.66, "end": 769.82, "word": " what", "probability": 0.93017578125}, {"start": 769.82, "end": 769.98, "word": " is", "probability": 0.9443359375}, {"start": 769.98, "end": 770.12, "word": " the", "probability": 0.91943359375}, {"start": 770.12, "end": 770.46, "word": " predicate?", "probability": 0.972412109375}, {"start": 770.56, "end": 770.68, "word": " Who", "probability": 0.86328125}, {"start": 770.68, "end": 770.88, "word": " can", "probability": 0.94921875}, {"start": 770.88, "end": 771.04, "word": " give", "probability": 0.884765625}, {"start": 771.04, "end": 771.14, "word": " me", "probability": 0.9580078125}, {"start": 771.14, "end": 771.32, "word": " a", "probability": 0.99560546875}, {"start": 771.32, "end": 771.66, "word": " sentence?", "probability": 0.9482421875}, {"start": 774.8, "end": 775.4, "word": " Give", "probability": 0.85595703125}, {"start": 775.4, "end": 775.5, "word": " me", "probability": 0.9619140625}, {"start": 775.5, "end": 775.7, "word": " a", "probability": 0.9970703125}, {"start": 775.7, "end": 776.08, "word": " sentence.", "probability": 0.93994140625}], "temperature": 1.0}, {"id": 31, "seek": 81022, "start": 782.36, "end": 810.22, "text": " Again, give me any sentence, yeah? I bought a red shirt Okay, where is the subject? I Now everything said about the subject is called a predicate Okay, so everything said about the subject is called what? 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The subject, you know the subject, the doer of the action. And the predicate, everything is said about the subject. I hope this is easy and clear. Okay, can you give me another sentence? Another sentence from your aunt. She bought a shirt. What did you buy? 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Okay. Tell me about where is the subject and the predicate? I is a subject and bought a bag is a predicate. Thank you. The weather is getting very cold. The weather is getting very cold. Yeah? The weather is subject and it's getting very cold is the predicate. Thank you. 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It is made of gold. Look at the underlying group of words. It has a subject and it has a predicate. It has a subject and a predicate.", "tokens": [634, 575, 257, 5021, 597, 307, 1027, 295, 3821, 13, 467, 307, 1027, 295, 3821, 13, 2053, 412, 264, 14217, 1594, 295, 2283, 13, 467, 575, 257, 3983, 293, 309, 575, 257, 3852, 8700, 13, 467, 575, 257, 3983, 293, 257, 3852, 8700, 13], "avg_logprob": -0.14592013359069825, "compression_ratio": 1.6074766355140186, "no_speech_prob": 0.0, "words": [{"start": 867.42, "end": 867.68, "word": " He", "probability": 0.79736328125}, {"start": 867.68, "end": 868.14, "word": " has", "probability": 0.943359375}, {"start": 868.14, "end": 868.36, "word": " a", "probability": 0.9921875}, {"start": 868.36, "end": 868.7, "word": " chain", "probability": 0.927734375}, {"start": 868.7, "end": 869.48, "word": " which", "probability": 0.7138671875}, {"start": 869.48, "end": 869.76, "word": " is", "probability": 0.951171875}, {"start": 869.76, "end": 870.02, "word": " made", "probability": 0.87939453125}, {"start": 870.02, "end": 870.22, "word": " of", "probability": 0.97119140625}, {"start": 870.22, "end": 870.6, "word": " gold.", "probability": 0.89208984375}, {"start": 875.14, "end": 875.92, "word": " It", "probability": 0.42431640625}, {"start": 875.92, "end": 877.62, "word": " is", "probability": 0.90869140625}, {"start": 877.62, "end": 878.06, "word": " made", "probability": 0.8759765625}, {"start": 878.06, "end": 878.26, "word": " of", "probability": 0.9716796875}, {"start": 878.26, "end": 878.66, "word": " gold.", "probability": 0.91064453125}, {"start": 881.0, "end": 881.78, "word": " Look", "probability": 0.45849609375}, {"start": 881.78, "end": 881.96, "word": " at", "probability": 0.96923828125}, {"start": 881.96, "end": 882.1, "word": " the", "probability": 0.92138671875}, {"start": 882.1, "end": 882.58, "word": " underlying", "probability": 0.60498046875}, {"start": 882.58, "end": 883.16, "word": " group", "probability": 0.94482421875}, {"start": 883.16, "end": 883.38, "word": " of", "probability": 0.96630859375}, {"start": 883.38, "end": 883.72, "word": " words.", "probability": 0.84765625}, {"start": 884.46, "end": 884.64, "word": " It", "probability": 0.93212890625}, {"start": 884.64, "end": 885.06, "word": " has", "probability": 0.94482421875}, {"start": 885.06, "end": 886.14, "word": " a", "probability": 0.96728515625}, {"start": 886.14, "end": 886.48, "word": " subject", "probability": 0.95751953125}, {"start": 886.48, "end": 887.02, "word": " and", "probability": 0.88916015625}, {"start": 887.02, "end": 887.18, "word": " it", "probability": 0.68310546875}, {"start": 887.18, "end": 887.66, "word": " has", "probability": 0.94580078125}, {"start": 887.66, "end": 888.4, "word": " a", "probability": 0.9931640625}, {"start": 888.4, "end": 888.84, "word": " predicate.", "probability": 0.962890625}, {"start": 889.18, "end": 889.64, "word": " It", "probability": 0.7822265625}, {"start": 889.64, "end": 889.94, "word": " has", "probability": 0.9423828125}, {"start": 889.94, "end": 890.14, "word": " a", "probability": 0.98388671875}, {"start": 890.14, "end": 890.48, "word": " subject", "probability": 0.96142578125}, {"start": 890.48, "end": 890.94, "word": " and", "probability": 0.94482421875}, {"start": 890.94, "end": 891.16, "word": " a", "probability": 0.97705078125}, {"start": 891.16, "end": 891.58, "word": " predicate.", "probability": 0.96923828125}], "temperature": 1.0}, {"id": 35, "seek": 91802, "start": 892.38, "end": 918.02, "text": " Does it give you a full meaning? Yes. Okay. Now, in fact, it gives a full meaning in the sentence. When you say, which is made of gold, what is it? Or it is made of gold. When you read the whole sentence, he has bought a chain, and you read the other clause, it gives a full meaning, a complete sense, right?", "tokens": [4402, 309, 976, 291, 257, 1577, 3620, 30, 1079, 13, 1033, 13, 823, 11, 294, 1186, 11, 309, 2709, 257, 1577, 3620, 294, 264, 8174, 13, 1133, 291, 584, 11, 597, 307, 1027, 295, 3821, 11, 437, 307, 309, 30, 1610, 309, 307, 1027, 295, 3821, 13, 1133, 291, 1401, 264, 1379, 8174, 11, 415, 575, 4243, 257, 5021, 11, 293, 291, 1401, 264, 661, 25925, 11, 309, 2709, 257, 1577, 3620, 11, 257, 3566, 2020, 11, 558, 30], "avg_logprob": -0.2246093748137355, "compression_ratio": 1.7657142857142858, "no_speech_prob": 0.0, "words": [{"start": 892.38, "end": 892.72, "word": " Does", "probability": 0.84326171875}, {"start": 892.72, "end": 892.88, "word": " it", "probability": 0.9365234375}, {"start": 892.88, "end": 893.1, "word": " give", "probability": 0.875}, {"start": 893.1, "end": 893.46, "word": " you", "probability": 0.9580078125}, {"start": 893.46, 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This group of words contains a subject and a predicate. And of course, the predicate contains a finite verb. It has a finite verb. A verb which has a tense. What are the types of clauses? It is very easy. You remember an adjective phrase?", "tokens": [823, 11, 718, 311, 574, 13, 639, 1594, 295, 2283, 8306, 257, 3983, 293, 257, 3852, 8700, 13, 400, 295, 1164, 11, 264, 3852, 8700, 8306, 257, 19362, 9595, 13, 467, 575, 257, 19362, 9595, 13, 316, 9595, 597, 575, 257, 18760, 13, 708, 366, 264, 3467, 295, 49072, 30, 467, 307, 588, 1858, 13, 509, 1604, 364, 44129, 9535, 30], "avg_logprob": -0.19191027889328618, "compression_ratio": 1.4970760233918128, "no_speech_prob": 0.0, "words": [{"start": 918.64, "end": 918.96, "word": " Now,", "probability": 0.82958984375}, {"start": 919.44, "end": 919.8, "word": " let's", "probability": 0.919921875}, {"start": 919.8, "end": 920.04, "word": " look.", "probability": 0.955078125}, {"start": 920.16, "end": 920.34, "word": " This", "probability": 0.8544921875}, {"start": 920.34, "end": 920.76, "word": " group", "probability": 0.9345703125}, {"start": 920.76, "end": 921.0, "word": " of", "probability": 0.9697265625}, {"start": 921.0, "end": 921.4, "word": " words", "probability": 0.841796875}, {"start": 921.4, "end": 922.64, "word": " contains", "probability": 0.8076171875}, {"start": 922.64, "end": 922.94, "word": " a", "probability": 0.9873046875}, {"start": 922.94, "end": 923.26, "word": " subject", "probability": 0.95947265625}, {"start": 923.26, "end": 923.64, "word": " and", "probability": 0.93896484375}, {"start": 923.64, "end": 923.82, "word": " a", "probability": 0.98095703125}, {"start": 923.82, "end": 924.28, "word": " predicate.", "probability": 0.96337890625}, {"start": 925.04, "end": 925.28, "word": " And", "probability": 0.87255859375}, {"start": 925.28, "end": 925.52, "word": " of", "probability": 0.7841796875}, {"start": 925.52, "end": 925.76, "word": " course,", "probability": 0.95361328125}, {"start": 925.88, "end": 926.0, "word": " the", "probability": 0.9111328125}, {"start": 926.0, "end": 926.42, "word": " predicate", "probability": 0.958251953125}, {"start": 926.42, "end": 927.1, "word": " contains", "probability": 0.8896484375}, {"start": 927.1, "end": 927.34, "word": " a", "probability": 0.99658203125}, {"start": 927.34, "end": 928.02, "word": " finite", "probability": 0.9736328125}, {"start": 928.02, "end": 928.48, "word": " verb.", "probability": 0.8896484375}, {"start": 928.72, "end": 929.14, "word": " It", "probability": 0.84716796875}, {"start": 929.14, "end": 929.56, "word": " has", "probability": 0.94287109375}, {"start": 929.56, "end": 929.76, "word": " a", "probability": 0.99755859375}, {"start": 929.76, "end": 930.22, "word": " finite", "probability": 0.947265625}, {"start": 930.22, "end": 930.58, "word": " verb.", "probability": 0.89208984375}, {"start": 931.04, "end": 931.24, "word": " A", "probability": 0.96728515625}, {"start": 931.24, "end": 931.54, "word": " verb", "probability": 0.8876953125}, {"start": 931.54, "end": 931.82, "word": " which", "probability": 0.83056640625}, {"start": 931.82, "end": 932.16, "word": " has", "probability": 0.9443359375}, {"start": 932.16, "end": 932.36, "word": " a", "probability": 0.98388671875}, {"start": 932.36, "end": 932.62, "word": " tense.", "probability": 0.919921875}, {"start": 933.28, "end": 933.52, "word": " What", "probability": 0.8876953125}, {"start": 933.52, "end": 933.94, "word": " are", "probability": 0.93603515625}, {"start": 933.94, "end": 934.28, "word": " the", "probability": 0.92041015625}, {"start": 934.28, "end": 935.84, "word": " types", "probability": 0.1875}, {"start": 935.84, "end": 936.1, "word": " of", "probability": 0.97119140625}, {"start": 936.1, "end": 936.54, "word": " clauses?", "probability": 0.9423828125}, {"start": 937.4, "end": 937.92, "word": " It", "probability": 0.9345703125}, {"start": 937.92, "end": 938.08, "word": " is", "probability": 0.9111328125}, {"start": 938.08, "end": 938.32, "word": " very", "probability": 0.85302734375}, {"start": 938.32, "end": 938.66, "word": " easy.", "probability": 0.90380859375}, {"start": 939.02, "end": 939.16, "word": " You", "probability": 0.91650390625}, {"start": 939.16, "end": 939.64, "word": " remember", "probability": 0.87548828125}, {"start": 939.64, "end": 942.46, "word": " an", "probability": 0.39501953125}, {"start": 942.46, "end": 944.4, "word": " adjective", "probability": 0.90771484375}, {"start": 944.4, "end": 945.14, "word": " phrase?", "probability": 0.81591796875}], "temperature": 1.0}, {"id": 37, "seek": 95870, "start": 946.92, "end": 958.7, "text": " What is an adjective phrase? What is it? It is the one which describes the noun. And the adjective clause is the one which", "tokens": [708, 307, 364, 44129, 9535, 30, 708, 307, 309, 30, 467, 307, 264, 472, 597, 15626, 264, 23307, 13, 400, 264, 44129, 25925, 307, 264, 472, 597], "avg_logprob": -0.22991071375352995, "compression_ratio": 1.3820224719101124, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 946.9200000000001, "end": 947.48, "word": " What", "probability": 0.415283203125}, {"start": 947.48, "end": 947.66, "word": " is", "probability": 0.89892578125}, {"start": 947.66, "end": 947.86, "word": " an", "probability": 0.75634765625}, {"start": 947.86, "end": 948.24, "word": " adjective", "probability": 0.91748046875}, {"start": 948.24, "end": 948.9, "word": " phrase?", "probability": 0.794921875}, {"start": 950.54, "end": 950.72, "word": " What", "probability": 0.450927734375}, {"start": 950.72, "end": 950.9, "word": " is", "probability": 0.9345703125}, {"start": 950.9, "end": 951.18, "word": " it?", "probability": 0.9462890625}, {"start": 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about the noun phrase? It's the object or the subject. The object or the subject. And the noun clause is also used as the subject and the object. Now look at the first sentence. Who wants to read? Najwa. You may sit wherever you like. What would you tell about this sentence?", "tokens": [823, 437, 466, 264, 23307, 9535, 30, 467, 311, 264, 2657, 420, 264, 3983, 13, 440, 2657, 420, 264, 3983, 13, 400, 264, 23307, 25925, 307, 611, 1143, 382, 264, 3983, 293, 264, 2657, 13, 823, 574, 412, 264, 700, 8174, 13, 2102, 2738, 281, 1401, 30, 31576, 4151, 13, 509, 815, 1394, 8660, 291, 411, 13, 708, 576, 291, 980, 466, 341, 8174, 30], "avg_logprob": -0.20288825373757968, "compression_ratio": 1.6964285714285714, "no_speech_prob": 0.0, "words": [{"start": 981.7, "end": 982.08, "word": " Now", "probability": 0.76123046875}, {"start": 982.08, "end": 982.32, "word": " what", "probability": 0.52099609375}, {"start": 982.32, "end": 982.72, "word": " about", "probability": 0.91455078125}, {"start": 982.72, "end": 983.26, "word": " the", "probability": 0.90380859375}, {"start": 983.26, "end": 983.58, "word": " noun", "probability": 0.70166015625}, {"start": 983.58, "end": 984.08, "word": " phrase?", "probability": 0.728515625}, {"start": 984.4, "end": 984.98, "word": " It's", "probability": 0.6710205078125}, {"start": 984.98, "end": 985.26, "word": " the", "probability": 0.84033203125}, {"start": 985.26, "end": 985.6, "word": " object", "probability": 0.92529296875}, {"start": 985.6, "end": 985.96, "word": " or", "probability": 0.92919921875}, {"start": 985.96, "end": 986.26, "word": " the", "probability": 0.8642578125}, {"start": 986.26, "end": 986.7, "word": " subject.", "probability": 0.96875}, {"start": 986.94, "end": 987.06, "word": " The", "probability": 0.57666015625}, {"start": 987.06, "end": 987.44, "word": " object", "probability": 0.9404296875}, {"start": 987.44, "end": 987.72, "word": " or", "probability": 0.94970703125}, {"start": 987.72, "end": 987.88, "word": " the", "probability": 0.90185546875}, {"start": 987.88, "end": 988.24, "word": " subject.", "probability": 0.9775390625}, {"start": 988.64, "end": 989.28, "word": " And", "probability": 0.666015625}, {"start": 989.28, "end": 989.5, "word": " the", "probability": 0.916015625}, {"start": 989.5, "end": 989.72, "word": " noun", "probability": 0.6728515625}, {"start": 989.72, "end": 990.26, "word": " clause", "probability": 0.88525390625}, {"start": 990.26, "end": 990.8, "word": " is", "probability": 0.94189453125}, {"start": 990.8, "end": 991.26, "word": " also", "probability": 0.84375}, {"start": 991.26, "end": 991.68, "word": " used", "probability": 0.90625}, {"start": 991.68, "end": 991.98, "word": " as", "probability": 0.9521484375}, {"start": 991.98, "end": 992.14, "word": " the", "probability": 0.8681640625}, {"start": 992.14, "end": 992.54, "word": " subject", "probability": 0.96630859375}, {"start": 992.54, "end": 992.82, "word": " and", "probability": 0.9189453125}, {"start": 992.82, "end": 992.92, "word": " the", "probability": 0.76513671875}, {"start": 992.92, "end": 993.2, "word": " object.", "probability": 0.9755859375}, {"start": 995.88, "end": 996.52, "word": " Now", "probability": 0.341552734375}, {"start": 996.52, "end": 996.8, "word": " look", "probability": 0.845703125}, {"start": 996.8, "end": 996.92, "word": " at", "probability": 0.96728515625}, {"start": 996.92, "end": 997.08, "word": " the", "probability": 0.9140625}, {"start": 997.08, "end": 997.46, "word": " first", "probability": 0.89697265625}, {"start": 997.46, "end": 998.26, "word": " sentence.", "probability": 0.92919921875}, {"start": 998.78, "end": 998.9, "word": " Who", "probability": 0.8642578125}, {"start": 998.9, "end": 999.2, "word": " wants", "probability": 0.830078125}, {"start": 999.2, "end": 999.4, "word": " to", "probability": 0.96826171875}, {"start": 999.4, "end": 999.66, "word": " read?", "probability": 0.97509765625}, {"start": 1000.22, "end": 1000.56, "word": " Najwa.", "probability": 0.929443359375}, {"start": 1003.7, "end": 1004.34, "word": " You", "probability": 0.86376953125}, {"start": 1004.34, "end": 1004.9, "word": " may", "probability": 0.93994140625}, {"start": 1004.9, "end": 1005.34, "word": " sit", "probability": 0.92236328125}, {"start": 1005.34, "end": 1005.82, "word": " wherever", "probability": 0.9404296875}, {"start": 1005.82, "end": 1006.24, "word": " you", "probability": 0.97119140625}, {"start": 1006.24, "end": 1006.54, "word": " like.", "probability": 0.92236328125}, {"start": 1006.68, "end": 1007.08, "word": " What", "probability": 0.350830078125}, {"start": 1007.08, "end": 1007.3, "word": " would", "probability": 0.90771484375}, {"start": 1007.3, "end": 1007.46, "word": " you", "probability": 0.9658203125}, {"start": 1007.46, "end": 1007.66, "word": " tell", "probability": 0.8505859375}, {"start": 1007.66, "end": 1007.96, "word": " about", "probability": 0.8896484375}, {"start": 1007.96, "end": 1008.18, "word": " this", "probability": 0.8720703125}, {"start": 1008.18, "end": 1008.56, "word": " sentence?", "probability": 0.92431640625}], "temperature": 1.0}, {"id": 40, "seek": 103953, "start": 1011.01, "end": 1039.53, "text": " Okay, there is a subject and a predicate. Good. So the underlying group of words. Adverbic clause. Very good. Thank you. You miss it where? Where? It qualifies the verb, right? You miss it where? Wherever you like. Thank you very much. Read the other one, please. Yes, you. Yes. 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Thank you. Yes. Who wants to comment on this clause? Yeah. Please comment on this clause because it describes how they behave. How? He behaves how? As one might expect him to do. Okay. He behaves how? Okay. Next one, please. 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If you eat too much. This is conditional. When you eat too much, you will be ill. Now, what would you say about adverbic clauses? Tell me. It's your turn to explain. 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The first volunteer, she, ya, nada, gone. It does the work of the adverb. Again. It does the work of the adverb. Okay. So it describes the verb. That's it, simply. It describes the verb. It does the work of the adverb. Okay? Now look at this exercise. 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Why? Because you have done this. Because you have done this. This is what?", "tokens": [1436, 291, 362, 1096, 341, 11, 286, 4393, 9842, 291, 13, 1545, 30, 1436, 291, 362, 1096, 341, 13, 1436, 291, 362, 1096, 341, 13, 639, 307, 437, 30], "avg_logprob": -0.34869790971279147, "compression_ratio": 1.64, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1120.4199999999998, "end": 1121.08, "word": " Because", "probability": 0.045166015625}, {"start": 1121.08, "end": 1121.64, "word": " you", "probability": 0.88916015625}, {"start": 1121.64, "end": 1122.02, "word": " have", "probability": 0.7890625}, {"start": 1122.02, "end": 1124.5, "word": " done", "probability": 0.830078125}, {"start": 1124.5, "end": 1124.84, "word": " this,", "probability": 0.9013671875}, {"start": 1124.96, "end": 1125.12, "word": " I", "probability": 0.93310546875}, {"start": 1125.12, "end": 1125.44, "word": " shall", "probability": 0.865234375}, {"start": 1125.44, "end": 1126.22, "word": " punish", "probability": 0.95751953125}, {"start": 1126.22, "end": 1127.1, "word": " you.", "probability": 0.8671875}, {"start": 1127.1, "end": 1127.5, "word": " Why?", "probability": 0.4521484375}, {"start": 1131.42, "end": 1132.08, "word": " Because", "probability": 0.254638671875}, {"start": 1132.08, "end": 1136.24, "word": " you", "probability": 0.90478515625}, {"start": 1136.24, "end": 1136.5, "word": " have", "probability": 0.82080078125}, {"start": 1136.5, "end": 1136.78, "word": " done", "probability": 0.83154296875}, {"start": 1136.78, "end": 1137.08, "word": " this.", "probability": 0.87451171875}, {"start": 1137.42, "end": 1138.08, "word": " Because", "probability": 0.39404296875}, {"start": 1138.08, "end": 1138.66, "word": " you", "probability": 0.94775390625}, {"start": 1138.66, "end": 1138.94, "word": " have", "probability": 0.94189453125}, {"start": 1138.94, "end": 1139.2, "word": " done", "probability": 0.9228515625}, {"start": 1139.2, "end": 1139.48, "word": " this.", "probability": 0.9404296875}, {"start": 1139.56, "end": 1139.7, "word": " This", "probability": 0.73876953125}, {"start": 1139.7, "end": 1139.86, "word": " is", "probability": 0.9404296875}, {"start": 1139.86, "end": 1140.16, "word": " what?", "probability": 0.93359375}], "temperature": 1.0}, {"id": 45, "seek": 116535, "start": 1142.78, "end": 1165.36, "text": " An adverbic clause. Thank you very much. Good. Yes, please. Next one. Number two. Why? Why did I speak to his brother? No, no, no. She. This is for her. Yeah, go on. Where is the adverbic clause? 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Now, what does in English, what does as mean? Because. Okay, good. Okay, so as he was not there. Thank you very much. Next one. 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Though he began late. Very good. Thank you. Yeah. Will you wait till I return? Yeah. Will I return? Where is the adverb closed? Till I return. Till I return. Thank you very much. Yes, please. 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Just as he entered the room. Okay. Now, when did the clock what? Struck. If I begin with dead, what shall I say? One speaker. When did the clock strike? Take care, okay? When did the clock strike? 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Adjective clauses, okay? Now, number one. Read, please. Say, a little lamb, a little cat. Okay? You know the lamb? Okay, good. Whose fleece?", "tokens": [1999, 1020, 488, 49072, 13, 1999, 1020, 488, 49072, 11, 1392, 30, 823, 11, 1230, 472, 13, 17604, 11, 1767, 13, 6463, 11, 257, 707, 10097, 11, 257, 707, 3857, 13, 1033, 30, 509, 458, 264, 10097, 30, 1033, 11, 665, 13, 28463, 25146, 384, 30], "avg_logprob": -0.20794547745522032, "compression_ratio": 1.3333333333333333, "no_speech_prob": 0.0, "words": [{"start": 1255.75, "end": 1256.43, "word": " Adjective", "probability": 0.9365234375}, {"start": 1256.43, "end": 1256.93, "word": " clauses.", "probability": 0.93896484375}, {"start": 1259.43, "end": 1260.11, "word": " Adjective", "probability": 0.9239908854166666}, {"start": 1260.11, "end": 1260.61, "word": " clauses,", "probability": 0.9541015625}, {"start": 1260.81, "end": 1260.97, "word": " okay?", "probability": 0.861328125}, {"start": 1262.51, "end": 1263.19, "word": " Now,", "probability": 0.93408203125}, {"start": 1263.45, "end": 1263.77, "word": " number", "probability": 0.916015625}, {"start": 1263.77, "end": 1264.15, "word": " one.", "probability": 0.85205078125}, {"start": 1264.75, "end": 1265.01, "word": " Read,", "probability": 0.880859375}, {"start": 1265.13, "end": 1265.43, "word": " please.", "probability": 0.81396484375}, {"start": 1267.33, "end": 1268.01, "word": " Say,", "probability": 0.53076171875}, {"start": 1268.13, "end": 1268.19, "word": " a", "probability": 0.1949462890625}, {"start": 1268.19, "end": 1268.53, "word": " little", "probability": 0.86669921875}, {"start": 1268.53, "end": 1269.09, "word": " lamb,", "probability": 0.86962890625}, {"start": 1269.17, "end": 1269.27, "word": " a", "probability": 0.98583984375}, {"start": 1269.27, "end": 1269.51, "word": " little", "probability": 0.87548828125}, {"start": 1269.51, "end": 1270.03, "word": " cat.", "probability": 0.9482421875}, {"start": 1270.77, "end": 1271.11, "word": " Okay?", "probability": 0.84765625}, {"start": 1271.43, "end": 1272.05, "word": " You", "probability": 0.9375}, {"start": 1272.05, "end": 1272.21, "word": " know", "probability": 0.89599609375}, {"start": 1272.21, "end": 1272.39, "word": " the", "probability": 0.638671875}, {"start": 1272.39, "end": 1272.65, "word": " lamb?", "probability": 0.86572265625}, {"start": 1273.45, "end": 1274.13, "word": " Okay,", "probability": 0.377685546875}, {"start": 1274.71, "end": 1275.01, "word": " good.", "probability": 0.93212890625}, {"start": 1276.15, "end": 1276.49, "word": " Whose", "probability": 0.857421875}, {"start": 1276.49, "end": 1277.03, "word": " fleece?", "probability": 0.883056640625}], "temperature": 1.0}, {"id": 50, "seek": 129229, "start": 1277.55, "end": 1292.29, "text": " Whose fleece was white as snow. Okay, now the underlined words, whose fleece was as white as snow. Yes. Yes, what would you comment? What would you say about this group of words? Yeah.", "tokens": [28463, 25146, 384, 390, 2418, 382, 5756, 13, 1033, 11, 586, 264, 833, 13564, 2283, 11, 6104, 25146, 384, 390, 382, 2418, 382, 5756, 13, 1079, 13, 1079, 11, 437, 576, 291, 2871, 30, 708, 576, 291, 584, 466, 341, 1594, 295, 2283, 30, 865, 13], "avg_logprob": -0.2764295073265725, "compression_ratio": 1.5040650406504066, "no_speech_prob": 0.0, "words": [{"start": 1277.55, "end": 1277.89, "word": " Whose", "probability": 0.4580078125}, {"start": 1277.89, "end": 1278.29, "word": " fleece", "probability": 0.936279296875}, {"start": 1278.29, "end": 1278.55, "word": " was", "probability": 0.9365234375}, {"start": 1278.55, "end": 1278.93, "word": " white", "probability": 0.52783203125}, {"start": 1278.93, "end": 1279.25, "word": " as", "probability": 0.95263671875}, {"start": 1279.25, "end": 1280.09, "word": " snow.", "probability": 0.6875}, {"start": 1280.43, "end": 1280.47, "word": " Okay,", "probability": 0.3818359375}, {"start": 1280.99, "end": 1281.31, "word": " now", "probability": 0.9375}, {"start": 1281.31, "end": 1281.83, "word": " the", "probability": 0.77880859375}, {"start": 1281.83, "end": 1282.53, "word": " underlined", "probability": 0.801513671875}, {"start": 1282.53, "end": 1283.01, "word": " words,", "probability": 0.8720703125}, {"start": 1283.79, "end": 1284.11, "word": " whose", "probability": 0.673828125}, {"start": 1284.11, "end": 1284.65, "word": " fleece", "probability": 0.9423828125}, {"start": 1284.65, "end": 1284.97, "word": " was", "probability": 0.95263671875}, {"start": 1284.97, "end": 1285.91, "word": " as", "probability": 0.462890625}, {"start": 1285.91, "end": 1286.29, "word": " white", "probability": 0.921875}, {"start": 1286.29, "end": 1286.63, "word": " as", "probability": 0.95751953125}, {"start": 1286.63, "end": 1286.99, "word": " snow.", "probability": 0.80224609375}, {"start": 1287.27, "end": 1287.35, "word": " Yes.", "probability": 0.78125}, {"start": 1287.51, "end": 1287.69, "word": " Yes,", "probability": 0.71044921875}, {"start": 1287.77, "end": 1287.91, "word": " what", "probability": 0.9326171875}, {"start": 1287.91, "end": 1288.07, "word": " would", "probability": 0.85009765625}, {"start": 1288.07, "end": 1288.19, "word": " you", "probability": 0.9599609375}, {"start": 1288.19, "end": 1288.57, "word": " comment?", "probability": 0.951171875}, {"start": 1288.75, "end": 1288.87, "word": " What", "probability": 0.8759765625}, {"start": 1288.87, "end": 1289.05, "word": " would", "probability": 0.9248046875}, {"start": 1289.05, "end": 1289.19, "word": " you", "probability": 0.96240234375}, {"start": 1289.19, "end": 1289.37, "word": " say", "probability": 0.947265625}, {"start": 1289.37, "end": 1289.67, "word": " about", "probability": 0.900390625}, {"start": 1289.67, "end": 1289.87, "word": " this", "probability": 0.9404296875}, {"start": 1289.87, "end": 1290.19, "word": " group", "probability": 0.96630859375}, {"start": 1290.19, "end": 1290.37, "word": " of", "probability": 0.97021484375}, {"start": 1290.37, "end": 1290.65, "word": " words?", "probability": 0.83984375}, {"start": 1291.65, "end": 1292.29, "word": " Yeah.", "probability": 0.55322265625}], "temperature": 1.0}, {"id": 51, "seek": 132445, "start": 1295.69, "end": 1324.45, "text": " It is an adjective clause. Very good. Thank you. Why it is an adjective clause? Yes, please. It has a subject and a precedence. A predicate. And it behaves as an adjective. Okay, thank you. Behaves describes the noun. Naveen, number two. The letter from money which was badly needed. Okay, what type of money? Okay, money. It describes what? Money. Which was badly needed. Yes, go on Naveen. 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Money. Okay, it is an adjective clause. Thank you very much. Why it is an adjective clause, Yasmeen? Because it describes the noun. Money. What type of money? Okay, thank you. The other one, please. 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Okay, it means people who die. It describes what? The noun. Thank you. 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Contains a subject and a predicate as the other clauses, good. It describes a noun and behave as adjectives. Okay, good. Thank you very much. Now look at the exercise. Number one, read the introduction. 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The house. Which house? Please, we want one speaker. Okay? One speaker. Don't talk together. She's speaking. Yeah, she can. Which house? That I live in. Very good. Now, when I say the house, it can be any house, right?", "tokens": [440, 1782, 300, 286, 1621, 294, 13, 440, 1782, 13, 3013, 1782, 30, 2555, 11, 321, 528, 472, 8145, 13, 1033, 30, 1485, 8145, 13, 1468, 380, 751, 1214, 13, 1240, 311, 4124, 13, 865, 11, 750, 393, 13, 3013, 1782, 30, 663, 286, 1621, 294, 13, 4372, 665, 13, 823, 11, 562, 286, 584, 264, 1782, 11, 309, 393, 312, 604, 1782, 11, 558, 30], "avg_logprob": -0.2037080152710872, "compression_ratio": 1.5506329113924051, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1404.15, "end": 1404.57, "word": " The", "probability": 0.560546875}, {"start": 1404.57, "end": 1404.85, "word": " house", "probability": 0.88525390625}, {"start": 1404.85, "end": 1405.19, "word": " that", "probability": 0.71875}, {"start": 1405.19, "end": 1405.71, "word": " I", "probability": 0.87451171875}, {"start": 1405.71, "end": 1405.97, "word": " live", "probability": 0.88916015625}, {"start": 1405.97, "end": 1406.45, "word": " in.", "probability": 0.80517578125}, {"start": 1407.29, "end": 1407.83, "word": " The", "probability": 0.27783203125}, {"start": 1407.83, "end": 1409.51, "word": " house.", "probability": 0.76904296875}, {"start": 1411.23, "end": 1411.63, "word": " Which", "probability": 0.85498046875}, {"start": 1411.63, "end": 1412.11, "word": " house?", "probability": 0.86962890625}, {"start": 1413.01, "end": 1413.65, "word": " Please,", "probability": 0.74755859375}, {"start": 1413.89, "end": 1414.03, "word": " we", "probability": 0.92626953125}, {"start": 1414.03, "end": 1414.35, "word": " want", "probability": 0.853515625}, {"start": 1414.35, "end": 1414.61, "word": " one", "probability": 0.90966796875}, {"start": 1414.61, "end": 1415.07, "word": " speaker.", "probability": 0.8994140625}, {"start": 1415.49, "end": 1415.71, "word": " Okay?", "probability": 0.76220703125}, {"start": 1416.49, "end": 1416.75, "word": " One", "probability": 0.90478515625}, {"start": 1416.75, "end": 1417.21, "word": " speaker.", "probability": 0.86474609375}, {"start": 1417.35, "end": 1417.57, "word": " Don't", "probability": 0.963623046875}, {"start": 1417.57, "end": 1417.89, "word": " talk", "probability": 0.89111328125}, {"start": 1417.89, "end": 1418.27, "word": " together.", "probability": 0.83203125}, {"start": 1418.65, "end": 1418.93, "word": " She's", "probability": 0.78857421875}, {"start": 1418.93, "end": 1419.41, "word": " speaking.", "probability": 0.88232421875}, {"start": 1420.11, "end": 1420.59, "word": " Yeah,", "probability": 0.82666015625}, {"start": 1420.77, "end": 1420.99, "word": " she", "probability": 0.91162109375}, {"start": 1420.99, "end": 1421.37, "word": " can.", "probability": 0.95263671875}, {"start": 1421.93, "end": 1422.19, "word": " Which", "probability": 0.89306640625}, {"start": 1422.19, "end": 1422.65, "word": " house?", "probability": 0.869140625}, {"start": 1424.13, "end": 1424.77, "word": " That", "probability": 0.81884765625}, {"start": 1424.77, "end": 1426.43, "word": " I", "probability": 0.978515625}, {"start": 1426.43, "end": 1426.81, "word": " live", "probability": 0.9384765625}, {"start": 1426.81, "end": 1427.19, "word": " in.", "probability": 0.9306640625}, {"start": 1427.31, "end": 1427.65, "word": " Very", "probability": 0.72216796875}, {"start": 1427.65, "end": 1427.89, "word": " good.", "probability": 0.919921875}, {"start": 1428.35, "end": 1428.55, "word": " Now,", "probability": 0.94384765625}, {"start": 1428.61, "end": 1428.75, "word": " when", "probability": 0.93896484375}, {"start": 1428.75, "end": 1428.91, "word": " I", "probability": 0.998046875}, {"start": 1428.91, "end": 1429.11, "word": " say", "probability": 0.94384765625}, {"start": 1429.11, "end": 1429.31, "word": " the", "probability": 0.75927734375}, {"start": 1429.31, "end": 1429.61, "word": " house,", "probability": 0.8798828125}, {"start": 1429.69, "end": 1429.79, "word": " it", "probability": 0.94287109375}, {"start": 1429.79, "end": 1429.95, "word": " can", "probability": 0.94189453125}, {"start": 1429.95, "end": 1430.11, "word": " be", "probability": 0.95849609375}, {"start": 1430.11, "end": 1430.35, "word": " any", "probability": 0.90087890625}, {"start": 1430.35, "end": 1430.67, "word": " house,", "probability": 0.876953125}, {"start": 1430.75, "end": 1431.01, "word": " right?", "probability": 0.9111328125}], "temperature": 1.0}, {"id": 56, "seek": 145105, "start": 1432.03, "end": 1451.05, "text": " The adjective also specifies the noun, right? The adjective, when I say girl, it can be any girl, right? But the tall girl, it makes the noun specific. House, which house? That I live in.", "tokens": [440, 44129, 611, 1608, 11221, 264, 23307, 11, 558, 30, 440, 44129, 11, 562, 286, 584, 2013, 11, 309, 393, 312, 604, 2013, 11, 558, 30, 583, 264, 6764, 2013, 11, 309, 1669, 264, 23307, 2685, 13, 4928, 11, 597, 1782, 30, 663, 286, 1621, 294, 13], "avg_logprob": -0.2179361910869678, "compression_ratio": 1.504, "no_speech_prob": 0.0, "words": [{"start": 1432.03, "end": 1432.29, "word": " The", "probability": 0.83251953125}, {"start": 1432.29, "end": 1432.81, "word": " adjective", "probability": 0.95166015625}, {"start": 1432.81, "end": 1433.49, "word": " also", "probability": 0.8408203125}, {"start": 1433.49, "end": 1434.49, "word": " specifies", "probability": 0.946533203125}, {"start": 1434.49, "end": 1434.73, "word": " the", "probability": 0.904296875}, {"start": 1434.73, "end": 1434.95, "word": " noun,", "probability": 0.9580078125}, {"start": 1435.23, "end": 1435.53, "word": " right?", "probability": 0.88671875}, {"start": 1436.47, "end": 1436.83, "word": " The", "probability": 0.798828125}, {"start": 1436.83, "end": 1437.35, "word": " adjective,", "probability": 0.97412109375}, {"start": 1437.71, "end": 1437.93, "word": " when", "probability": 0.9267578125}, {"start": 1437.93, "end": 1438.09, "word": " I", "probability": 0.994140625}, {"start": 1438.09, "end": 1438.31, "word": " say", "probability": 0.9453125}, {"start": 1438.31, "end": 1438.73, "word": " girl,", "probability": 0.7021484375}, {"start": 1439.27, "end": 1439.47, "word": " it", "probability": 0.931640625}, {"start": 1439.47, "end": 1439.67, "word": " can", "probability": 0.92724609375}, {"start": 1439.67, "end": 1439.85, "word": " be", "probability": 0.95458984375}, {"start": 1439.85, "end": 1440.13, "word": " any", "probability": 0.91796875}, {"start": 1440.13, "end": 1440.37, "word": " girl,", "probability": 0.8359375}, {"start": 1440.47, "end": 1440.79, "word": " right?", "probability": 0.8271484375}, {"start": 1441.17, "end": 1441.43, "word": " But", "probability": 0.908203125}, {"start": 1441.43, "end": 1441.67, "word": " the", "probability": 0.80224609375}, {"start": 1441.67, "end": 1442.29, "word": " tall", "probability": 0.845703125}, {"start": 1442.29, "end": 1442.77, "word": " girl,", "probability": 0.78662109375}, {"start": 1443.65, "end": 1444.55, "word": " it", "probability": 0.406005859375}, {"start": 1444.55, "end": 1444.89, "word": " makes", "probability": 0.424560546875}, {"start": 1444.89, "end": 1445.09, "word": " the", "probability": 0.908203125}, {"start": 1445.09, "end": 1445.45, "word": " noun", "probability": 0.98095703125}, {"start": 1445.45, "end": 1446.77, "word": " specific.", "probability": 0.88232421875}, {"start": 1446.93, "end": 1447.31, "word": " House,", "probability": 0.76611328125}, {"start": 1447.45, "end": 1447.67, "word": " which", "probability": 0.9501953125}, {"start": 1447.67, "end": 1448.19, "word": " house?", "probability": 0.87548828125}, {"start": 1448.79, "end": 1449.31, "word": " That", "probability": 0.35009765625}, {"start": 1449.31, "end": 1450.53, "word": " I", "probability": 0.98681640625}, {"start": 1450.53, "end": 1450.85, "word": " live", "probability": 0.947265625}, {"start": 1450.85, "end": 1451.05, "word": " in.", "probability": 0.94384765625}], "temperature": 1.0}, {"id": 57, "seek": 147512, "start": 1451.84, "end": 1475.12, "text": " That I live in. Yeah, thank you. I have a little shadow which goes in and out with me. Which goes in and out with me. Thank you. That's right. Thank you. Yeah? The dog that bites doesn't bite. Adjective clauses that bites doesn't bite. That bites doesn't. Okay, the dog. Now, again, where is the adjective clause?", "tokens": [663, 286, 1621, 294, 13, 865, 11, 1309, 291, 13, 286, 362, 257, 707, 8576, 597, 1709, 294, 293, 484, 365, 385, 13, 3013, 1709, 294, 293, 484, 365, 385, 13, 1044, 291, 13, 663, 311, 558, 13, 1044, 291, 13, 865, 30, 440, 3000, 300, 26030, 1177, 380, 7988, 13, 1999, 1020, 488, 49072, 300, 26030, 1177, 380, 7988, 13, 663, 26030, 1177, 380, 13, 1033, 11, 264, 3000, 13, 823, 11, 797, 11, 689, 307, 264, 44129, 25925, 30], "avg_logprob": -0.32145578323340995, "compression_ratio": 1.8470588235294119, "no_speech_prob": 0.0, "words": [{"start": 1451.84, "end": 1452.14, "word": " That", "probability": 0.374267578125}, {"start": 1452.14, "end": 1452.38, "word": " I", "probability": 0.841796875}, {"start": 1452.38, "end": 1452.66, "word": " live", "probability": 0.935546875}, {"start": 1452.66, "end": 1452.92, "word": " in.", "probability": 0.93994140625}, {"start": 1453.18, "end": 1453.34, "word": " Yeah,", "probability": 0.5673828125}, 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That bites. Okay? The dog that bites. Which dog? That bites. Okay. Thank you. Yes, please. He tells a tale that sounds untrue. That sounds untrue. Okay, good. Thank you. And finally. Yes? It is an owl. Owl and that one. That's not a nobody and a god. That's not. 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1507.11, "end": 1533.71, "text": " Now, which wind? Which wind? That blows nobody any good. Okay? That blows nobody any good. Okay? It describes what? The noun. Good. Now, you can look at the answers. And finally, noun clauses.", "tokens": [823, 11, 597, 2468, 30, 3013, 2468, 30, 663, 18458, 5079, 604, 665, 13, 1033, 30, 663, 18458, 5079, 604, 665, 13, 1033, 30, 467, 15626, 437, 30, 440, 23307, 13, 2205, 13, 823, 11, 291, 393, 574, 412, 264, 6338, 13, 400, 2721, 11, 23307, 49072, 13], "avg_logprob": -0.2927295918367347, "compression_ratio": 1.5078125, "no_speech_prob": 0.0, "words": [{"start": 1507.11, "end": 1508.03, "word": " Now,", "probability": 0.270263671875}, {"start": 1508.37, "end": 1508.67, "word": " which", "probability": 0.8994140625}, {"start": 1508.67, "end": 1509.19, "word": " wind?", "probability": 0.91162109375}, {"start": 1509.93, "end": 1510.41, "word": " Which", "probability": 0.413330078125}, {"start": 1510.41, "end": 1510.81, "word": " wind?", "probability": 0.8876953125}, {"start": 1512.93, "end": 1513.85, "word": " That", "probability": 0.736328125}, {"start": 1513.85, "end": 1515.29, "word": " blows", "probability": 0.69970703125}, {"start": 1515.29, "end": 1516.17, "word": " nobody", "probability": 0.916015625}, {"start": 1516.17, "end": 1516.57, "word": " any", "probability": 0.89013671875}, {"start": 1516.57, "end": 1517.15, "word": " good.", "probability": 0.88720703125}, {"start": 1517.39, "end": 1517.69, "word": " Okay?", "probability": 0.53369140625}, {"start": 1518.57, "end": 1519.07, "word": " That", "probability": 0.66015625}, {"start": 1519.07, "end": 1519.57, "word": " blows", "probability": 0.7568359375}, {"start": 1519.57, "end": 1520.99, "word": " nobody", "probability": 0.92724609375}, {"start": 1520.99, "end": 1521.43, "word": " any", "probability": 0.9140625}, {"start": 1521.43, "end": 1521.73, "word": " good.", "probability": 0.9287109375}, {"start": 1521.95, "end": 1522.33, "word": " Okay?", "probability": 0.62353515625}, {"start": 1522.39, "end": 1522.57, "word": " It", "probability": 0.91650390625}, {"start": 1522.57, "end": 1523.09, "word": " describes", "probability": 0.86376953125}, {"start": 1523.09, "end": 1523.53, "word": " what?", "probability": 0.94091796875}, {"start": 1524.79, "end": 1524.93, "word": " The", "probability": 0.57763671875}, {"start": 1524.93, "end": 1525.15, "word": " noun.", "probability": 0.58349609375}, {"start": 1525.91, "end": 1526.27, "word": " Good.", "probability": 0.63720703125}, {"start": 1526.87, "end": 1527.49, "word": " Now,", "probability": 0.9501953125}, {"start": 1527.75, "end": 1527.97, "word": " you", "probability": 0.9619140625}, {"start": 1527.97, "end": 1528.23, "word": " can", "probability": 0.94482421875}, {"start": 1528.23, "end": 1528.45, "word": " look", "probability": 0.96533203125}, {"start": 1528.45, "end": 1528.57, "word": " at", "probability": 0.96337890625}, {"start": 1528.57, "end": 1528.71, "word": " the", "probability": 0.9189453125}, {"start": 1528.71, "end": 1529.19, "word": " answers.", "probability": 0.8642578125}, {"start": 1530.15, "end": 1530.35, "word": " And", "probability": 0.92822265625}, {"start": 1530.35, "end": 1530.93, "word": " finally,", "probability": 0.82275390625}, {"start": 1531.71, "end": 1531.95, "word": " noun", "probability": 0.43115234375}, {"start": 1531.95, "end": 1533.71, "word": " clauses.", "probability": 0.521484375}], "temperature": 1.0}, {"id": 60, "seek": 153955, "start": 1534.97, "end": 1539.55, "text": " Now Nick closes. Who wants to start? Who wants to speak? Now it's your turn, Morida.", "tokens": [823, 9449, 24157, 13, 2102, 2738, 281, 722, 30, 2102, 2738, 281, 1710, 30, 823, 309, 311, 428, 1261, 11, 5146, 2887, 13], "avg_logprob": -0.2908528782427311, "compression_ratio": 1.0897435897435896, "no_speech_prob": 0.0, "words": [{"start": 1534.97, "end": 1535.31, "word": " Now", "probability": 0.56982421875}, {"start": 1535.31, "end": 1535.55, "word": " Nick", "probability": 0.318359375}, {"start": 1535.55, "end": 1535.95, "word": " closes.", "probability": 0.416015625}, {"start": 1536.17, "end": 1536.35, "word": " Who", "probability": 0.72607421875}, {"start": 1536.35, "end": 1536.73, "word": " wants", "probability": 0.8681640625}, {"start": 1536.73, "end": 1536.97, "word": " to", "probability": 0.97265625}, {"start": 1536.97, "end": 1537.35, "word": " start?", "probability": 0.89697265625}, {"start": 1537.45, "end": 1537.57, "word": " Who", "probability": 0.857421875}, {"start": 1537.57, "end": 1537.85, "word": " wants", "probability": 0.8447265625}, {"start": 1537.85, "end": 1537.99, "word": " to", "probability": 0.9736328125}, {"start": 1537.99, "end": 1538.23, "word": " speak?", "probability": 0.9736328125}, {"start": 1538.35, "end": 1538.47, "word": " Now", "probability": 0.9091796875}, {"start": 1538.47, "end": 1538.71, "word": " it's", "probability": 0.90771484375}, {"start": 1538.71, "end": 1538.87, "word": " your", "probability": 0.8955078125}, {"start": 1538.87, "end": 1539.17, "word": " turn,", "probability": 0.8310546875}, {"start": 1539.23, "end": 1539.55, "word": " Morida.", "probability": 0.571533203125}], "temperature": 1.0}, {"id": 61, "seek": 156728, "start": 1540.64, "end": 1567.28, "text": " I expect that I shall get a prize. Yes, what would you say about this sentence? That I shall get a prize. It has a subject and a predicate. A predicate, so it is a clause. So, what type of a clause? It's not a clause. Why? Because it has a subject. It is a subject. Very good. It is the object. Where is the object of the sentence? 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That I shall get a prize, okay? So this is the object, right? This is the object. Of course, because it is the object, this clause is an object, it is a noun clause. Next one. That you should say this is very strange. A subject and a predicate. Where is the subject and where is the predicate? That you should say they are predicate.", "tokens": [286, 2066, 437, 30, 663, 286, 4393, 483, 257, 12818, 11, 1392, 30, 407, 341, 307, 264, 2657, 11, 558, 30, 639, 307, 264, 2657, 13, 2720, 1164, 11, 570, 309, 307, 264, 2657, 11, 341, 25925, 307, 364, 2657, 11, 309, 307, 257, 23307, 25925, 13, 3087, 472, 13, 663, 291, 820, 584, 341, 307, 588, 5861, 13, 316, 3983, 293, 257, 3852, 8700, 13, 2305, 307, 264, 3983, 293, 689, 307, 264, 3852, 8700, 30, 663, 291, 820, 584, 436, 366, 3852, 8700, 13], "avg_logprob": -0.2121048867702484, "compression_ratio": 1.8967391304347827, "no_speech_prob": 0.0, "words": [{"start": 1568.63, "end": 1568.95, "word": " I", "probability": 0.7783203125}, {"start": 1568.95, "end": 1569.43, "word": " expect", "probability": 0.91796875}, {"start": 1569.43, "end": 1569.73, "word": " what?", "probability": 0.86669921875}, {"start": 1570.23, "end": 1570.53, "word": " That", "probability": 0.79736328125}, {"start": 1570.53, "end": 1570.77, "word": " I", "probability": 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Okay. Now where is the clause? Where is the clause? Okay, thank you. And where is the subject of the sentence? That you should say this is very strange. Where is the subject of the sentence?", "tokens": [2305, 307, 264, 3983, 30, 1033, 13, 823, 689, 307, 264, 25925, 30, 2305, 307, 264, 25925, 30, 1033, 11, 1309, 291, 13, 400, 689, 307, 264, 3983, 295, 264, 8174, 30, 663, 291, 820, 584, 341, 307, 588, 5861, 13, 2305, 307, 264, 3983, 295, 264, 8174, 30], "avg_logprob": -0.1943749949336052, "compression_ratio": 1.717741935483871, "no_speech_prob": 0.0, "words": [{"start": 1598.9, "end": 1599.38, "word": " Where", "probability": 0.483154296875}, {"start": 1599.38, "end": 1599.54, "word": " is", "probability": 0.9013671875}, {"start": 1599.54, "end": 1599.72, "word": " the", "probability": 0.90625}, {"start": 1599.72, "end": 1600.08, "word": " subject?", "probability": 0.955078125}, {"start": 1607.3, "end": 1607.78, "word": " Okay.", "probability": 0.2093505859375}, {"start": 1610.74, "end": 1611.22, "word": " Now", "probability": 0.88134765625}, {"start": 1611.22, "end": 1611.44, "word": " where", "probability": 0.55517578125}, {"start": 1611.44, "end": 1611.6, "word": " is", "probability": 0.93017578125}, {"start": 1611.6, "end": 1611.78, "word": " the", "probability": 0.79736328125}, {"start": 1611.78, "end": 1612.14, "word": " clause?", "probability": 0.8740234375}, {"start": 1612.82, "end": 1612.96, "word": " Where", "probability": 0.4814453125}, {"start": 1612.96, "end": 1613.12, "word": " is", "probability": 0.93310546875}, {"start": 1613.12, "end": 1613.26, "word": " the", "probability": 0.841796875}, {"start": 1613.26, "end": 1613.6, "word": " clause?", "probability": 0.85791015625}, {"start": 1616.44, "end": 1616.92, "word": " Okay,", "probability": 0.69384765625}, {"start": 1617.02, "end": 1617.26, "word": " thank", "probability": 0.83349609375}, {"start": 1617.26, "end": 1617.42, "word": " you.", "probability": 0.96142578125}, {"start": 1617.52, "end": 1617.72, "word": " And", "probability": 0.884765625}, {"start": 1617.72, "end": 1617.92, "word": " where", "probability": 0.923828125}, {"start": 1617.92, "end": 1618.08, "word": " is", "probability": 0.935546875}, {"start": 1618.08, "end": 1618.24, "word": " the", "probability": 0.91943359375}, {"start": 1618.24, "end": 1618.64, "word": " subject", "probability": 0.96533203125}, {"start": 1618.64, "end": 1618.98, "word": " of", "probability": 0.96435546875}, {"start": 1618.98, "end": 1619.16, "word": " the", "probability": 0.9130859375}, {"start": 1619.16, "end": 1619.58, "word": " sentence?", "probability": 0.93896484375}, {"start": 1619.78, "end": 1620.04, "word": " That", "probability": 0.6923828125}, {"start": 1620.04, "end": 1620.22, "word": " you", "probability": 0.85498046875}, {"start": 1620.22, "end": 1620.52, "word": " should", "probability": 0.9658203125}, {"start": 1620.52, "end": 1620.76, "word": " say", "probability": 0.94580078125}, {"start": 1620.76, "end": 1621.02, "word": " this", "probability": 0.86474609375}, {"start": 1621.02, "end": 1621.22, "word": " is", "probability": 0.83642578125}, {"start": 1621.22, "end": 1622.08, "word": " very", "probability": 0.5791015625}, {"start": 1622.08, "end": 1622.46, "word": " strange.", "probability": 0.89794921875}, {"start": 1622.54, "end": 1622.72, "word": " Where", "probability": 0.8447265625}, {"start": 1622.72, "end": 1622.86, "word": " is", "probability": 0.93359375}, {"start": 1622.86, "end": 1623.0, "word": " the", "probability": 0.91552734375}, {"start": 1623.0, "end": 1623.26, "word": " subject", "probability": 0.96337890625}, {"start": 1623.26, "end": 1623.5, "word": " of", "probability": 0.95458984375}, {"start": 1623.5, "end": 1623.66, "word": " the", "probability": 0.90771484375}, {"start": 1623.66, "end": 1623.96, "word": " sentence?", "probability": 0.9326171875}], "temperature": 1.0}, {"id": 64, "seek": 164797, "start": 1625.63, "end": 1647.97, "text": " Okay, read it, read it again. That you… Okay, it is the subject of the sentence. Good. And because this clause is used as the subject of the sentence, it is what? It is a noun clause, okay? So, what are noun clauses?", "tokens": [1033, 11, 1401, 309, 11, 1401, 309, 797, 13, 663, 291, 1260, 1033, 11, 309, 307, 264, 3983, 295, 264, 8174, 13, 2205, 13, 400, 570, 341, 25925, 307, 1143, 382, 264, 3983, 295, 264, 8174, 11, 309, 307, 437, 30, 467, 307, 257, 23307, 25925, 11, 1392, 30, 407, 11, 437, 366, 23307, 49072, 30], "avg_logprob": -0.23314144736842105, "compression_ratio": 1.5755395683453237, "no_speech_prob": 0.0, "words": [{"start": 1625.6299999999999, "end": 1626.11, "word": " Okay,", "probability": 0.57958984375}, {"start": 1626.41, "end": 1626.77, "word": " read", "probability": 0.93896484375}, {"start": 1626.77, "end": 1626.95, "word": " it,", "probability": 0.958984375}, {"start": 1627.03, "end": 1627.17, "word": " read", "probability": 0.96826171875}, {"start": 1627.17, "end": 1627.31, "word": " it", "probability": 0.95361328125}, {"start": 1627.31, "end": 1627.63, "word": " again.", "probability": 0.9521484375}, {"start": 1627.77, "end": 1627.93, "word": " That", "probability": 0.57568359375}, {"start": 1627.93, "end": 1631.93, "word": " you…", "probability": 0.444091796875}, {"start": 1631.93, "end": 1631.93, "word": " Okay,", "probability": 0.34130859375}, {"start": 1635.53, "end": 1635.67, "word": " it", "probability": 0.92822265625}, {"start": 1635.67, "end": 1635.85, "word": " is", "probability": 0.91162109375}, {"start": 1635.85, "end": 1636.69, "word": " the", "probability": 0.6123046875}, {"start": 1636.69, "end": 1637.09, "word": " subject", "probability": 0.9697265625}, {"start": 1637.09, "end": 1637.39, "word": " of", "probability": 0.97119140625}, {"start": 1637.39, "end": 1637.55, "word": " the", "probability": 0.91064453125}, {"start": 1637.55, "end": 1638.07, "word": " sentence.", "probability": 0.94091796875}, {"start": 1638.29, "end": 1638.65, "word": " Good.", "probability": 0.8037109375}, {"start": 1638.85, "end": 1638.99, "word": " And", "probability": 0.9111328125}, {"start": 1638.99, "end": 1639.45, "word": " because", "probability": 0.88818359375}, {"start": 1639.45, "end": 1640.13, "word": " this", "probability": 0.93603515625}, {"start": 1640.13, "end": 1640.59, "word": " clause", "probability": 0.8447265625}, {"start": 1640.59, "end": 1640.85, "word": " is", "probability": 0.9501953125}, {"start": 1640.85, "end": 1641.21, "word": " used", "probability": 0.91162109375}, {"start": 1641.21, "end": 1641.45, "word": " as", "probability": 0.9638671875}, {"start": 1641.45, "end": 1641.65, "word": " the", "probability": 0.8857421875}, {"start": 1641.65, "end": 1642.05, "word": " subject", "probability": 0.9638671875}, {"start": 1642.05, "end": 1642.31, "word": " of", "probability": 0.96875}, {"start": 1642.31, "end": 1642.49, "word": " the", "probability": 0.904296875}, {"start": 1642.49, "end": 1642.93, "word": " sentence,", "probability": 0.93505859375}, {"start": 1643.07, "end": 1643.17, "word": " it", "probability": 0.94189453125}, {"start": 1643.17, "end": 1643.33, "word": " is", "probability": 0.9306640625}, {"start": 1643.33, "end": 1643.63, "word": " what?", "probability": 0.90771484375}, {"start": 1644.21, "end": 1644.69, "word": " It", "probability": 0.9365234375}, {"start": 1644.69, "end": 1644.89, "word": " is", "probability": 0.90966796875}, {"start": 1644.89, "end": 1645.05, "word": " a", "probability": 0.96337890625}, {"start": 1645.05, "end": 1645.25, "word": " noun", "probability": 0.78564453125}, {"start": 1645.25, "end": 1645.73, "word": " clause,", "probability": 0.896484375}, {"start": 1645.87, "end": 1646.11, "word": " okay?", "probability": 0.90087890625}, {"start": 1646.45, "end": 1646.83, "word": " So,", "probability": 0.87109375}, {"start": 1646.97, "end": 1647.05, "word": " what", "probability": 0.94921875}, {"start": 1647.05, "end": 1647.29, "word": " are", "probability": 0.9384765625}, {"start": 1647.29, "end": 1647.53, "word": " noun", "probability": 0.8603515625}, {"start": 1647.53, "end": 1647.97, "word": " clauses?", "probability": 0.8916015625}], "temperature": 1.0}, {"id": 65, "seek": 167624, "start": 1648.72, "end": 1676.24, "text": " Noun clauses also it contains by subject and predicate and maybe it should be object or subject. So, thank you very much. A noun clause is, you know, it contains a subject and a predicate as all the other clauses and it is the subject or the object of the sentence.", "tokens": [426, 1733, 49072, 611, 309, 8306, 538, 3983, 293, 3852, 8700, 293, 1310, 309, 820, 312, 2657, 420, 3983, 13, 407, 11, 1309, 291, 588, 709, 13, 316, 23307, 25925, 307, 11, 291, 458, 11, 309, 8306, 257, 3983, 293, 257, 3852, 8700, 382, 439, 264, 661, 49072, 293, 309, 307, 264, 3983, 420, 264, 2657, 295, 264, 8174, 13], "avg_logprob": -0.2433401590487996, "compression_ratio": 1.7272727272727273, "no_speech_prob": 0.0, "words": [{"start": 1648.72, "end": 1649.02, "word": " Noun", "probability": 0.614501953125}, {"start": 1649.02, "end": 1649.38, "word": " clauses", "probability": 0.79443359375}, {"start": 1649.38, "end": 1650.32, "word": " also", "probability": 0.5341796875}, {"start": 1650.32, "end": 1650.58, "word": " it", "probability": 0.5029296875}, {"start": 1650.58, "end": 1651.08, "word": " contains", "probability": 0.81640625}, {"start": 1651.08, "end": 1651.44, "word": " by", "probability": 0.40966796875}, {"start": 1651.44, "end": 1652.22, "word": " subject", "probability": 0.91162109375}, {"start": 1652.22, "end": 1652.92, "word": " and", "probability": 0.93017578125}, {"start": 1652.92, "end": 1654.3, "word": " predicate", "probability": 0.501220703125}, {"start": 1654.3, "end": 1656.72, "word": " and", "probability": 0.376708984375}, {"start": 1656.72, "end": 1657.68, "word": " maybe", "probability": 0.9189453125}, {"start": 1657.68, "end": 1658.26, "word": " it", "probability": 0.95166015625}, {"start": 1658.26, "end": 1658.78, "word": " should", "probability": 0.9658203125}, {"start": 1658.78, "end": 1659.18, "word": " be", "probability": 0.9521484375}, {"start": 1659.18, "end": 1660.6, "word": " object", "probability": 0.853515625}, {"start": 1660.6, "end": 1661.06, "word": " or", "probability": 0.92333984375}, {"start": 1661.06, "end": 1662.74, "word": " subject.", "probability": 0.6865234375}, {"start": 1662.92, "end": 1663.06, "word": " So,", "probability": 0.37451171875}, {"start": 1663.4, "end": 1663.84, "word": " thank", "probability": 0.814453125}, {"start": 1663.84, "end": 1664.0, "word": " you", "probability": 0.96533203125}, {"start": 1664.0, "end": 1664.2, "word": " very", "probability": 0.85400390625}, {"start": 1664.2, "end": 1664.52, "word": " much.", "probability": 0.91552734375}, {"start": 1664.62, "end": 1664.74, "word": " A", "probability": 0.92724609375}, {"start": 1664.74, "end": 1664.92, "word": " noun", "probability": 0.9287109375}, {"start": 1664.92, "end": 1665.54, "word": " clause", "probability": 0.88330078125}, {"start": 1665.54, "end": 1666.9, "word": " is,", "probability": 0.546875}, {"start": 1667.24, "end": 1667.42, "word": " you", "probability": 0.88427734375}, {"start": 1667.42, "end": 1667.64, "word": " know,", "probability": 0.88818359375}, {"start": 1667.78, "end": 1667.96, "word": " it", "probability": 0.94580078125}, {"start": 1667.96, "end": 1668.62, "word": " contains", "probability": 0.9072265625}, {"start": 1668.62, "end": 1669.16, "word": " a", "probability": 0.9130859375}, {"start": 1669.16, "end": 1669.54, "word": " subject", "probability": 0.96923828125}, {"start": 1669.54, "end": 1669.9, "word": " and", "probability": 0.93798828125}, {"start": 1669.9, "end": 1670.06, "word": " a", "probability": 0.93896484375}, {"start": 1670.06, "end": 1670.5, "word": " predicate", "probability": 0.96142578125}, {"start": 1670.5, "end": 1671.22, "word": " as", "probability": 0.81689453125}, {"start": 1671.22, "end": 1671.68, "word": " all", "probability": 0.94677734375}, {"start": 1671.68, "end": 1671.84, "word": " the", "probability": 0.90869140625}, {"start": 1671.84, "end": 1672.08, "word": " other", "probability": 0.89697265625}, {"start": 1672.08, "end": 1672.56, "word": " clauses", "probability": 0.93701171875}, {"start": 1672.56, "end": 1673.74, "word": " and", "probability": 0.5947265625}, {"start": 1673.74, "end": 1673.98, "word": " it", "probability": 0.95458984375}, {"start": 1673.98, "end": 1674.14, "word": " is", "probability": 0.94189453125}, {"start": 1674.14, "end": 1674.32, "word": " the", "probability": 0.9013671875}, {"start": 1674.32, "end": 1674.7, "word": " subject", "probability": 0.9697265625}, {"start": 1674.7, "end": 1675.04, "word": " or", "probability": 0.9541015625}, {"start": 1675.04, "end": 1675.2, "word": " the", "probability": 0.87744140625}, {"start": 1675.2, "end": 1675.48, "word": " object", "probability": 0.974609375}, {"start": 1675.48, "end": 1675.76, "word": " of", "probability": 0.96875}, {"start": 1675.76, "end": 1675.92, "word": " the", "probability": 0.9150390625}, {"start": 1675.92, "end": 1676.24, "word": " sentence.", "probability": 0.9462890625}], "temperature": 1.0}, {"id": 66, "seek": 170567, "start": 1677.61, "end": 1705.67, "text": " I hope it is clear. Now look at the exercise. Yes, you there at the back. Start the introduction. Yeah. Now I wonder. Yeah, go on. I wonder what?", "tokens": [286, 1454, 309, 307, 1850, 13, 823, 574, 412, 264, 5380, 13, 1079, 11, 291, 456, 412, 264, 646, 13, 6481, 264, 9339, 13, 865, 13, 823, 286, 2441, 13, 865, 11, 352, 322, 13, 286, 2441, 437, 30], "avg_logprob": -0.22734374552965164, "compression_ratio": 1.3272727272727274, "no_speech_prob": 0.0, "words": [{"start": 1677.61, "end": 1677.87, "word": " I", "probability": 0.873046875}, {"start": 1677.87, "end": 1678.15, "word": " hope", "probability": 0.90966796875}, {"start": 1678.15, "end": 1678.31, "word": " it", "probability": 0.91748046875}, {"start": 1678.31, "end": 1678.45, "word": " is", "probability": 0.82763671875}, {"start": 1678.45, "end": 1678.83, "word": " clear.", "probability": 0.90380859375}, {"start": 1680.17, "end": 1680.67, "word": " Now", "probability": 0.85791015625}, {"start": 1680.67, "end": 1680.93, "word": " look", "probability": 0.78173828125}, {"start": 1680.93, "end": 1681.07, "word": " at", "probability": 0.96923828125}, {"start": 1681.07, "end": 1681.17, "word": " the", "probability": 0.8994140625}, {"start": 1681.17, "end": 1681.89, "word": " exercise.", "probability": 0.947265625}, {"start": 1682.35, "end": 1682.61, "word": " Yes,", "probability": 0.89892578125}, {"start": 1682.71, "end": 1682.85, "word": " you", "probability": 0.95849609375}, {"start": 1682.85, "end": 1683.17, "word": " there", "probability": 0.87451171875}, {"start": 1683.17, "end": 1685.57, "word": " at", "probability": 0.447509765625}, {"start": 1685.57, "end": 1685.75, "word": " the", "probability": 0.92578125}, {"start": 1685.75, "end": 1686.11, "word": " back.", "probability": 0.87451171875}, {"start": 1687.77, "end": 1688.13, "word": " Start", "probability": 0.67529296875}, {"start": 1688.13, "end": 1690.19, "word": " the", "probability": 0.6337890625}, {"start": 1690.19, "end": 1690.67, "word": " introduction.", "probability": 0.92138671875}, {"start": 1698.27, "end": 1698.99, "word": " Yeah.", "probability": 0.2386474609375}, {"start": 1701.25, "end": 1701.97, "word": " Now", "probability": 0.91796875}, {"start": 1701.97, "end": 1702.31, "word": " I", "probability": 0.853515625}, {"start": 1702.31, "end": 1702.77, "word": " wonder.", "probability": 0.88623046875}, {"start": 1702.91, "end": 1703.07, "word": " Yeah,", "probability": 0.5771484375}, {"start": 1703.13, "end": 1703.25, "word": " go", "probability": 0.96923828125}, {"start": 1703.25, "end": 1703.49, "word": " on.", "probability": 0.94580078125}, {"start": 1704.47, "end": 1704.85, "word": " I", "probability": 0.9580078125}, {"start": 1704.85, "end": 1705.25, "word": " wonder", "probability": 0.89404296875}, {"start": 1705.25, "end": 1705.67, "word": " what?", "probability": 0.9267578125}], "temperature": 1.0}, {"id": 67, "seek": 173371, "start": 1708.07, "end": 1733.71, "text": " Okay, good. What's that? Very good. One. It is one clause. Thank you. Your neighbor. Yeah. Okay. I feel what? Just a minute. Just a minute. I feel what? What's the answer to what? Okay. So where is the clause?", "tokens": [1033, 11, 665, 13, 708, 311, 300, 30, 4372, 665, 13, 1485, 13, 467, 307, 472, 25925, 13, 1044, 291, 13, 2260, 5987, 13, 865, 13, 1033, 13, 286, 841, 437, 30, 1449, 257, 3456, 13, 1449, 257, 3456, 13, 286, 841, 437, 30, 708, 311, 264, 1867, 281, 437, 30, 1033, 13, 407, 689, 307, 264, 25925, 30], "avg_logprob": -0.22057291716337205, "compression_ratio": 1.5, "no_speech_prob": 0.0, "words": [{"start": 1708.07, "end": 1708.45, "word": " Okay,", "probability": 0.67822265625}, {"start": 1708.55, "end": 1708.81, "word": " good.", "probability": 0.9033203125}, {"start": 1708.95, "end": 1709.27, "word": " What's", "probability": 0.912109375}, {"start": 1709.27, "end": 1709.67, "word": " that?", "probability": 0.94140625}, {"start": 1711.27, "end": 1711.57, "word": " Very", "probability": 0.62060546875}, {"start": 1711.57, "end": 1711.87, "word": " good.", "probability": 0.9189453125}, {"start": 1712.01, "end": 1712.23, "word": " One.", "probability": 0.2347412109375}, {"start": 1713.21, "end": 1713.69, "word": " It", "probability": 0.8857421875}, {"start": 1713.69, "end": 1713.85, "word": " is", "probability": 0.79248046875}, {"start": 1713.85, "end": 1714.09, "word": " one", "probability": 0.91796875}, {"start": 1714.09, "end": 1714.43, "word": " clause.", "probability": 0.90087890625}, {"start": 1714.55, "end": 1714.71, "word": " Thank", "probability": 0.8330078125}, {"start": 1714.71, "end": 1714.85, "word": " you.", "probability": 0.962890625}, {"start": 1714.91, "end": 1715.07, "word": " Your", "probability": 0.66015625}, {"start": 1715.07, "end": 1715.41, "word": " neighbor.", "probability": 0.8037109375}, {"start": 1717.49, "end": 1717.63, "word": " Yeah.", "probability": 0.422607421875}, {"start": 1723.53, "end": 1724.01, "word": " Okay.", "probability": 0.6494140625}, {"start": 1724.55, "end": 1724.89, "word": " I", "probability": 0.94970703125}, {"start": 1724.89, "end": 1725.27, "word": " feel", "probability": 0.9697265625}, {"start": 1725.27, "end": 1725.63, "word": " what?", "probability": 0.93798828125}, {"start": 1726.63, "end": 1727.11, "word": " Just", "probability": 0.71630859375}, {"start": 1727.11, "end": 1728.03, "word": " a", "probability": 0.998046875}, {"start": 1728.03, "end": 1728.23, "word": " minute.", "probability": 0.9208984375}, {"start": 1728.43, "end": 1728.53, "word": " Just", "probability": 0.397216796875}, {"start": 1728.53, "end": 1728.73, "word": " a", "probability": 0.99853515625}, {"start": 1728.73, "end": 1728.87, "word": " minute.", "probability": 0.9306640625}, {"start": 1729.03, "end": 1729.19, "word": " I", "probability": 0.94921875}, {"start": 1729.19, "end": 1729.47, "word": " feel", "probability": 0.96923828125}, {"start": 1729.47, "end": 1729.73, "word": " what?", "probability": 0.94580078125}, {"start": 1729.79, "end": 1730.03, "word": " What's", "probability": 0.931640625}, {"start": 1730.03, "end": 1730.17, "word": " the", "probability": 0.92529296875}, {"start": 1730.17, "end": 1730.49, "word": " answer", "probability": 0.955078125}, {"start": 1730.49, "end": 1730.71, "word": " to", "probability": 0.9384765625}, {"start": 1730.71, "end": 1730.99, "word": " what?", "probability": 0.912109375}, {"start": 1731.99, "end": 1732.47, "word": " Okay.", "probability": 0.83154296875}, {"start": 1732.63, "end": 1732.81, "word": " So", "probability": 0.962890625}, {"start": 1732.81, "end": 1733.05, "word": " where", "probability": 0.6064453125}, {"start": 1733.05, "end": 1733.17, "word": " is", "probability": 0.90771484375}, {"start": 1733.17, "end": 1733.33, "word": " the", "probability": 0.80419921875}, {"start": 1733.33, "end": 1733.71, "word": " clause?", "probability": 0.87158203125}], "temperature": 1.0}, {"id": 68, "seek": 175753, "start": 1735.25, "end": 1757.53, "text": " Where is it? Read it again. Read the clause only. That I shall fail. Thank you. Good. It is a noun clause because it is the object of the sentence. The one behind you, Yasmeen. Behind you. That you have come against me.", "tokens": [2305, 307, 309, 30, 17604, 309, 797, 13, 17604, 264, 25925, 787, 13, 663, 286, 4393, 3061, 13, 1044, 291, 13, 2205, 13, 467, 307, 257, 23307, 25925, 570, 309, 307, 264, 2657, 295, 264, 8174, 13, 440, 472, 2261, 291, 11, 30557, 1398, 268, 13, 20475, 291, 13, 663, 291, 362, 808, 1970, 385, 13], "avg_logprob": -0.18900767543859648, "compression_ratio": 1.4666666666666666, "no_speech_prob": 0.0, "words": [{"start": 1735.25, "end": 1735.59, "word": " Where", "probability": 0.64111328125}, {"start": 1735.59, "end": 1735.81, "word": " is", "probability": 0.9111328125}, {"start": 1735.81, "end": 1736.07, "word": " it?", "probability": 0.58837890625}, {"start": 1736.39, "end": 1736.71, "word": " Read", "probability": 0.8984375}, {"start": 1736.71, "end": 1736.87, "word": " it", "probability": 0.90869140625}, {"start": 1736.87, "end": 1737.15, "word": " again.", "probability": 0.9501953125}, {"start": 1737.23, "end": 1737.45, "word": " Read", "probability": 0.88330078125}, {"start": 1737.45, "end": 1737.73, "word": " the", "probability": 0.8837890625}, {"start": 1737.73, "end": 1738.21, "word": " clause", "probability": 0.8798828125}, {"start": 1738.21, "end": 1738.83, "word": " only.", "probability": 0.892578125}, {"start": 1741.51, "end": 1742.01, "word": " That", "probability": 0.4384765625}, {"start": 1742.01, "end": 1742.25, "word": " I", "probability": 0.90478515625}, {"start": 1742.25, "end": 1742.51, "word": " shall", "probability": 0.93115234375}, {"start": 1742.51, "end": 1742.87, "word": " fail.", "probability": 0.96044921875}, {"start": 1742.97, "end": 1743.17, "word": " Thank", "probability": 0.6982421875}, {"start": 1743.17, "end": 1743.41, "word": " you.", "probability": 0.90283203125}, {"start": 1743.53, "end": 1743.75, "word": " Good.", "probability": 0.86328125}, {"start": 1743.99, "end": 1744.31, "word": " It", "probability": 0.92626953125}, {"start": 1744.31, "end": 1744.45, "word": " is", "probability": 0.85595703125}, {"start": 1744.45, "end": 1744.63, "word": " a", "probability": 0.9140625}, {"start": 1744.63, "end": 1744.81, "word": " noun", "probability": 0.8076171875}, {"start": 1744.81, "end": 1745.31, "word": " clause", "probability": 0.8359375}, {"start": 1745.31, "end": 1746.21, "word": " because", "probability": 0.76416015625}, {"start": 1746.21, "end": 1746.43, "word": " it", "probability": 0.939453125}, {"start": 1746.43, "end": 1746.57, "word": " is", "probability": 0.8935546875}, {"start": 1746.57, "end": 1746.71, "word": " the", "probability": 0.89599609375}, {"start": 1746.71, "end": 1747.01, "word": " object", "probability": 0.86474609375}, {"start": 1747.01, "end": 1747.23, "word": " of", "probability": 0.9560546875}, {"start": 1747.23, "end": 1747.41, "word": " the", "probability": 0.8955078125}, {"start": 1747.41, "end": 1747.87, "word": " sentence.", "probability": 0.91845703125}, {"start": 1748.03, "end": 1748.15, "word": " The", "probability": 0.84033203125}, {"start": 1748.15, "end": 1748.35, "word": " one", "probability": 0.8603515625}, {"start": 1748.35, "end": 1748.81, "word": " behind", "probability": 0.94140625}, {"start": 1748.81, "end": 1749.01, "word": " you,", "probability": 0.96484375}, {"start": 1749.09, "end": 1749.43, "word": " Yasmeen.", "probability": 0.7902018229166666}, {"start": 1752.23, "end": 1752.73, "word": " Behind", "probability": 0.369140625}, {"start": 1752.73, "end": 1753.27, "word": " you.", "probability": 0.96142578125}, {"start": 1755.61, "end": 1756.11, "word": " That", "probability": 0.8759765625}, {"start": 1756.11, "end": 1756.31, "word": " you", "probability": 0.90185546875}, {"start": 1756.31, "end": 1756.57, "word": " have", "probability": 0.94189453125}, {"start": 1756.57, "end": 1756.81, "word": " come", "probability": 0.63818359375}, {"start": 1756.81, "end": 1757.13, "word": " against", "probability": 0.85302734375}, {"start": 1757.13, "end": 1757.53, "word": " me.", "probability": 0.951171875}], "temperature": 1.0}, {"id": 69, "seek": 178781, "start": 1760.75, "end": 1787.81, "text": " Okay, that you have come. What pleases me? That you have come. Why is it a noun clause? Why is it a noun clause? It is the subject of the sentence. It is the subject of the sentence. Thank you. Next one. He implied that he would come with a noun clause because it is the subject and object of the sentence.", "tokens": [1033, 11, 300, 291, 362, 808, 13, 708, 3362, 1957, 385, 30, 663, 291, 362, 808, 13, 1545, 307, 309, 257, 23307, 25925, 30, 1545, 307, 309, 257, 23307, 25925, 30, 467, 307, 264, 3983, 295, 264, 8174, 13, 467, 307, 264, 3983, 295, 264, 8174, 13, 1044, 291, 13, 3087, 472, 13, 634, 32614, 300, 415, 576, 808, 365, 257, 23307, 25925, 570, 309, 307, 264, 3983, 293, 2657, 295, 264, 8174, 13], "avg_logprob": -0.2787500047683716, "compression_ratio": 2.033112582781457, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 1760.75, "end": 1761.13, "word": " Okay,", "probability": 0.50048828125}, {"start": 1761.45, "end": 1761.69, "word": " that", "probability": 0.7724609375}, {"start": 1761.69, "end": 1761.87, "word": " you", "probability": 0.943359375}, {"start": 1761.87, "end": 1762.13, "word": " have", "probability": 0.93994140625}, {"start": 1762.13, "end": 1762.41, 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Okay, it is the object. Thank you. And the last one? Yes? I thought that it would be a fine day. That it would be a fine day. It's now closed because it's the object of Islam. Thank you very much. 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Okay? It contains different sentences, different phrases, and different clauses. Underline. Read. The underline, not now. This is homework.", "tokens": [639, 307, 364, 5380, 13, 1033, 30, 467, 8306, 819, 16579, 11, 819, 20312, 11, 293, 819, 49072, 13, 6974, 1889, 13, 17604, 13, 440, 833, 1889, 11, 406, 586, 13, 639, 307, 14578, 13], "avg_logprob": -0.24500866731007895, "compression_ratio": 1.3416666666666666, "no_speech_prob": 0.0, "words": [{"start": 1811.06, "end": 1811.4, "word": " This", "probability": 0.78466796875}, {"start": 1811.4, "end": 1811.64, "word": " is", "probability": 0.94580078125}, {"start": 1811.64, "end": 1812.52, "word": " an", "probability": 0.73681640625}, {"start": 1812.52, "end": 1813.2, "word": " exercise.", "probability": 0.95556640625}, {"start": 1813.9, "end": 1814.06, "word": " Okay?", "probability": 0.374755859375}, {"start": 1814.64, "end": 1814.92, "word": " It", "probability": 0.95556640625}, {"start": 1814.92, "end": 1815.56, "word": " contains", "probability": 0.90673828125}, {"start": 1815.56, "end": 1816.22, "word": " different", "probability": 0.90673828125}, {"start": 1816.22, "end": 1817.34, "word": " sentences,", "probability": 0.95751953125}, {"start": 1817.66, "end": 1817.96, "word": " different", "probability": 0.88232421875}, {"start": 1817.96, "end": 1818.54, "word": " phrases,", "probability": 0.84814453125}, {"start": 1819.16, "end": 1819.22, "word": " and", "probability": 0.93505859375}, {"start": 1819.22, "end": 1819.64, "word": " different", "probability": 0.88623046875}, {"start": 1819.64, "end": 1820.24, "word": " clauses.", "probability": 0.95458984375}, {"start": 1821.02, "end": 1822.04, "word": " Underline.", "probability": 0.8212890625}, {"start": 1822.46, "end": 1823.38, "word": " Read.", "probability": 0.8466796875}, {"start": 1824.36, "end": 1824.74, "word": " The", "probability": 0.74609375}, {"start": 1824.74, "end": 1825.42, "word": " underline,", "probability": 0.924560546875}, {"start": 1825.5, "end": 1825.66, "word": " not", "probability": 0.8857421875}, {"start": 1825.66, "end": 1826.02, "word": " now.", "probability": 0.94189453125}, {"start": 1826.94, "end": 1827.18, "word": " This", "probability": 0.59326171875}, {"start": 1827.18, "end": 1827.46, "word": " is", "probability": 0.95068359375}, {"start": 1827.46, "end": 1828.06, "word": " homework.", "probability": 0.88671875}], "temperature": 1.0}, {"id": 72, "seek": 184647, "start": 1828.91, "end": 1846.47, "text": " Okay? And read the underlined group of words carefully. Decide whether it is a phrase or a clause. And what type of a phrase or what type of a clause. Then tick the right box there. Is that okay? Yes. Thank you very much and see you on Saturday.", "tokens": [1033, 30, 400, 1401, 264, 833, 13564, 1594, 295, 2283, 7500, 13, 12427, 482, 1968, 309, 307, 257, 9535, 420, 257, 25925, 13, 400, 437, 2010, 295, 257, 9535, 420, 437, 2010, 295, 257, 25925, 13, 1396, 5204, 264, 558, 2424, 456, 13, 1119, 300, 1392, 30, 1079, 13, 1044, 291, 588, 709, 293, 536, 291, 322, 8803, 13], "avg_logprob": -0.17825521056850752, "compression_ratio": 1.490909090909091, "no_speech_prob": 2.384185791015625e-06, "words": [{"start": 1828.91, "end": 1829.43, "word": " Okay?", "probability": 0.595703125}, {"start": 1830.21, "end": 1830.41, "word": " And", "probability": 0.49072265625}, {"start": 1830.41, "end": 1830.81, "word": " read", "probability": 0.9443359375}, {"start": 1830.81, "end": 1831.03, "word": " the", "probability": 0.92626953125}, {"start": 1831.03, "end": 1831.63, "word": " underlined", "probability": 0.830078125}, {"start": 1831.63, "end": 1832.01, "word": " group", "probability": 0.9296875}, 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b/PL9fwy3NUQKwbIzP2HcHyqZInR8Lh3hu8w/gCmrApI29w0_raw.srt @@ -0,0 +1,1456 @@ +1 +00:00:21,510 --> 00:00:24,290 +Okay. Good morning to you all. Good morning. How + +2 +00:00:24,290 --> 00:00:29,670 +are you? Fine. Feeling well today? Yes. Not bad. + +3 +00:00:29,950 --> 00:00:32,990 +Not bad. Okay. Say Alhamdulillah. Alhamdulillah. + +4 +00:00:33,450 --> 00:00:37,450 +Now, can you give me a sentence? Any sentence. + +5 +00:00:37,590 --> 00:00:39,790 +Think of a sentence. Give me a sentence, Murida. + +6 +00:00:40,050 --> 00:00:44,050 +Ali drinks milk. Ali drinks milk. Good. Milk. Ali + +7 +00:00:44,050 --> 00:00:50,900 +drinks. Good. Now, another one. Yeah. Good, thank + +8 +00:00:50,900 --> 00:00:57,200 +you very much. Now, when I say he, Ali, drinks + +9 +00:00:57,200 --> 00:01:00,720 +milk. + +10 +00:01:03,260 --> 00:01:11,340 +Now, can I say Ali drink? Can I say Ali drink? No. + +11 +00:01:12,200 --> 00:01:19,140 +Why not? Because it is... Okay, so we want to say + +12 +00:01:19,140 --> 00:01:23,860 +that the verb should agree with the subject. The + +13 +00:01:23,860 --> 00:01:26,400 +verb should agree with the subject. There should + +14 +00:01:26,400 --> 00:01:30,780 +be what? There should be subject. + +15 +00:01:32,680 --> 00:01:38,100 +There should be subject-verb agreement. There + +16 +00:01:38,100 --> 00:01:43,840 +should be subject-verb agreement. He is. She is. + +17 +00:01:44,060 --> 00:01:51,140 +You are. I am. She works. You work. I play. You + +18 +00:01:51,140 --> 00:01:54,120 +play. She plays. Okay, this is called what? + +19 +00:01:54,640 --> 00:01:58,620 +Subject. So again, the subject should agree with + +20 +00:01:58,620 --> 00:02:03,020 +the verb. Certain verbs need certain subjects. + +21 +00:02:03,200 --> 00:02:10,680 +Okay? Now, if you look at the sentence, if I say + +22 +00:02:10,680 --> 00:02:19,570 +car, it is one. Singular, thank you. Two cars. Two + +23 +00:02:19,570 --> 00:02:24,230 +cars. How did I make the plural? How did I make + +24 +00:02:24,230 --> 00:02:28,570 +the plural? By adding? Okay, thank you very much. + +25 +00:02:28,690 --> 00:02:33,230 +So, when we add S to the number, to the singular, + +26 +00:02:34,330 --> 00:02:39,390 +it becomes what? Okay, now we say friends are + +27 +00:02:39,390 --> 00:02:46,230 +important and I like my classes. How did we make + +28 +00:02:46,230 --> 00:02:51,090 +the plural? What did we add? S or ES. So some + +29 +00:02:51,090 --> 00:02:58,700 +nouns. Take S and others take ES. Okay, now a + +30 +00:02:58,700 --> 00:03:04,420 +final S or ES is added to the singular and it + +31 +00:03:04,420 --> 00:03:10,800 +becomes what? Plural. This can be applied to nouns + +32 +00:03:10,800 --> 00:03:15,500 +and to verbs. We have singular nouns and singular + +33 +00:03:15,500 --> 00:03:20,920 +verbs. What is a singular verb? What is a singular + +34 +00:03:20,920 --> 00:03:29,270 +verb? Can you give me an example? Verb, a singular + +35 +00:03:29,270 --> 00:03:36,750 +verb. Now, when I say R, is it a verb? Yes, R is a + +36 +00:03:36,750 --> 00:03:41,330 +verb. Is it singular or plural? Can you give me a + +37 +00:03:41,330 --> 00:03:45,710 +singular verb? Yes, is. You are right. Thank you. + +38 +00:03:45,890 --> 00:03:51,730 +And? Was, good. Who's the speaker? Okay. Thank + +39 +00:03:51,730 --> 00:03:55,330 +you. Am. Work. Very good. Thank you very much. So + +40 +00:03:55,330 --> 00:04:00,430 +we have singular verbs and we have singular nouns. + +41 +00:04:01,210 --> 00:04:04,570 +Yeah. Singular verbs and singular nouns, plural + +42 +00:04:04,570 --> 00:04:11,050 +verbs and plural nouns. And the general rule is + +43 +00:04:11,050 --> 00:04:16,270 +that singular + +44 +00:04:16,270 --> 00:04:21,310 +verbs go with singular Nouns and plural verbs go + +45 +00:04:21,310 --> 00:04:24,090 +with the plural nouns, plural with the plural and + +46 +00:04:24,090 --> 00:04:28,150 +singular with singular. Okay, again, how can we + +47 +00:04:28,150 --> 00:04:31,010 +make the plural from nouns? Can you repeat please? + +48 +00:04:31,950 --> 00:04:33,070 +By adding. + +49 +00:04:37,090 --> 00:04:41,450 +That's it. Just add S or ES to the noun, and it + +50 +00:04:41,450 --> 00:04:44,770 +turns into what? Plural. Now, what about the verb? + +51 +00:04:45,530 --> 00:04:48,070 +What about the verb? If you look at this sentence, + +52 +00:04:48,230 --> 00:04:54,790 +Mona works. Jihad watches. They watch. We watch. + +53 +00:04:55,510 --> 00:05:01,310 +We work. He works. She works. How did we make that + +54 +00:05:01,310 --> 00:05:07,450 +plural from the verb? By adding S or E? Okay, + +55 +00:05:07,570 --> 00:05:10,510 +thank you. So again Marwa, can you tell me how do + +56 +00:05:10,510 --> 00:05:14,230 +we make the plural from the nouns and the verbs? + +57 +00:05:15,430 --> 00:05:19,690 +We just add S or ES. Good, thank you very much. We + +58 +00:05:19,690 --> 00:05:28,850 +add S or ES. Okay. Now, you remember we talked + +59 +00:05:28,850 --> 00:05:35,430 +about The pronunciation of the ED. When we talked + +60 +00:05:35,430 --> 00:05:39,630 +about regular and irregular verbs. Okay, this ED + +61 +00:05:39,630 --> 00:05:43,370 +with a regular verb can be pronounced in three + +62 +00:05:43,370 --> 00:05:48,110 +ways. It can be what? T sound, can be D sound. + +63 +00:05:48,850 --> 00:05:54,870 +Okay, who can remind us when do we pronounce it T, + +64 +00:05:55,430 --> 00:05:58,290 +when D and when ED? Yes, please. + +65 +00:06:03,810 --> 00:06:06,710 +Voiceless sound. Very good. So this is voiceless + +66 +00:06:06,710 --> 00:06:12,130 +after voiceless. Thank you. Voiced after voiced. + +67 +00:06:12,410 --> 00:06:17,410 +Good. Thank you very much. Now we have the same + +68 +00:06:17,410 --> 00:06:22,930 +story. With the S, okay? And with the ES in the + +69 +00:06:22,930 --> 00:06:26,590 +plural. How do we pronounce them? So when we + +70 +00:06:26,590 --> 00:06:31,410 +pronounce the ED in the regular verbs, we consider + +71 +00:06:31,410 --> 00:06:35,930 +what? Voiced and voiceless sounds, okay? Now the + +72 +00:06:35,930 --> 00:06:39,370 +same thing we consider. If you look at this word, + +73 +00:06:40,190 --> 00:06:44,950 +who can read? Yes, please. Seats. Seats. Seats. + +74 +00:06:45,410 --> 00:06:51,470 +Look, S is what? S. Voiceless. And T is voiceless. + +75 +00:06:51,710 --> 00:06:57,830 +So how did we pronounce it? Seats. Okay, again. + +76 +00:06:58,610 --> 00:07:06,390 +Now, yes please, Yasmin. Okay, S. Why S? It is a + +77 +00:07:06,390 --> 00:07:08,870 +voiceless after a voiceless sound. Thank you. + +78 +00:07:09,350 --> 00:07:15,850 +Khadija? Backs. Okay, why S? Voiceless after + +79 +00:07:15,850 --> 00:07:19,770 +voiceless, okay? So again, voiceless after + +80 +00:07:19,770 --> 00:07:22,130 +voiceless. Look at these words, they end with + +81 +00:07:22,130 --> 00:07:26,810 +voiceless sounds. So we need, we pronounce it C, + +82 +00:07:26,990 --> 00:07:32,310 +sabacs, okay? Seats and so on. It is C sound after + +83 +00:07:32,310 --> 00:07:38,250 +voiceless. Remember that this is not a syllable, + +84 +00:07:38,850 --> 00:07:44,250 +okay? Now, seats is one syllable. All of it is one + +85 +00:07:44,250 --> 00:07:47,450 +syllable. Okay? It is not considered a complete + +86 +00:07:47,450 --> 00:07:50,570 +syllable. If you look at the new group of words, + +87 +00:07:50,690 --> 00:07:55,190 +can you please read dua? Read the first one. Seed. + +88 +00:07:55,290 --> 00:08:02,390 +Look again. Seeds. Seeds. Okay? Why did she say Z? + +89 +00:08:02,950 --> 00:08:08,850 +Final S. This is Z. Why? Yes, Ken. It is? Voiced + +90 +00:08:08,850 --> 00:08:12,870 +after voiced. This sound, D sound is what? Voice. + +91 +00:08:13,010 --> 00:08:19,830 +Thank you. Next one, please. Okay. So again, why + +92 +00:08:19,830 --> 00:08:25,470 +did we pronounce it Z sound? Voiced after voiced. + +93 +00:08:25,710 --> 00:08:29,670 +Okay. Z is what? A voiced sound. Thank you. Yes, + +94 +00:08:29,730 --> 00:08:35,220 +Sahar. What about this one? Back. Voice after + +95 +00:08:35,220 --> 00:08:38,080 +voice. Thank you very much. Again. Yes, please. + +96 +00:08:40,470 --> 00:08:43,270 +voiced after voiced. Thank you very much. Now + +97 +00:08:43,270 --> 00:08:46,670 +again, this group, in this group, we pronounce the + +98 +00:08:46,670 --> 00:08:51,670 +final S as what? Z sound. Because it is voiced + +99 +00:08:51,670 --> 00:08:56,230 +after what? Voiced. And this is not a syllable. + +100 +00:08:56,510 --> 00:09:00,670 +This sound, Z sound is not a syllable. Okay? All + +101 +00:09:00,670 --> 00:09:03,590 +the word seeds is one syllable. It is not + +102 +00:09:03,590 --> 00:09:06,710 +considered, this sound is not considered a + +103 +00:09:06,710 --> 00:09:09,150 +syllable. Now look at the new group. Can you + +104 +00:09:09,150 --> 00:09:15,640 +please read the first one? Dishes. Dishes. Dishes. + +105 +00:09:16,060 --> 00:09:22,300 +We have schwa and z sound. Okay. Yes, Shayma. How + +106 +00:09:22,300 --> 00:09:25,080 +many syllables do we have? Two syllables. Two + +107 +00:09:25,080 --> 00:09:26,660 +syllables. Thank you very much. We have two + +108 +00:09:26,660 --> 00:09:34,050 +syllables. So this is, this E is after Okay. S-H, + +109 +00:09:34,170 --> 00:09:39,430 +we pronounce it what? Dishes. Dishes. Thank you. + +110 +00:09:39,650 --> 00:09:42,590 +Next one, please. Read it. Catches. Catches. + +111 +00:09:43,270 --> 00:09:45,830 +Kisses. Kisses. Thank you very much. Yes, please. + +112 +00:09:46,090 --> 00:09:51,270 +Mixes. Mixes. Yeah. Prizes. Prizes. Yeah. Edges. + +113 +00:09:51,970 --> 00:09:55,770 +Edges. Now, how many syllables do we have here in + +114 +00:09:55,770 --> 00:09:58,890 +dishes? Very good. We have two syllables. Thank + +115 +00:09:58,890 --> 00:10:07,540 +you. Now, after... after yes please read after yes + +116 +00:10:07,540 --> 00:10:18,860 +read okay + +117 +00:10:18,860 --> 00:10:22,280 +okay + +118 +00:10:22,280 --> 00:10:22,940 +okay + +119 +00:10:29,660 --> 00:10:33,280 +Thank you very much. So it is one syllable by + +120 +00:10:33,280 --> 00:10:37,880 +itself. Okay, now look at the spelling. Now this + +121 +00:10:37,880 --> 00:10:43,940 +is saying and song, verb and noun. Okay, verb and + +122 +00:10:43,940 --> 00:10:50,420 +noun. Now, how can we look for most of the verbs + +123 +00:10:50,420 --> 00:10:55,140 +and nouns? For most of the verbs and nouns, we add + +124 +00:10:55,140 --> 00:11:00,520 +what? To make it plural, in general, in general, + +125 +00:11:00,720 --> 00:11:04,340 +most of the words. By word, we mean what? Verb or + +126 +00:11:04,340 --> 00:11:08,100 +noun. Simply, we add what? S. So most of the + +127 +00:11:08,100 --> 00:11:11,600 +words, most, not all of the words in English take + +128 +00:11:11,600 --> 00:11:15,500 +S to be plural, whether they are nouns or verbs. + +129 +00:11:15,640 --> 00:11:21,020 +Look, sing, this is a verb, sings. Song, song. So + +130 +00:11:21,020 --> 00:11:25,840 +simply, we add what? S. But some words need what? + +131 +00:11:26,620 --> 00:11:31,840 +ES for example. Yes, please read. Watches. Thank + +132 +00:11:31,840 --> 00:11:36,520 +you. Next one. Watches. Thank you. Next. Thank + +133 +00:11:36,520 --> 00:11:42,420 +you. Yes, please. Next one. Buzzes. Yes, read it. + +134 +00:11:43,660 --> 00:11:47,340 +Buzzes. Okay. Next one. Boxes. Boxes. Thank you. + +135 +00:11:47,480 --> 00:11:58,300 +So, after what? Look. CH. We add what? We add ES. + +136 +00:11:58,920 --> 00:12:04,320 +So for most of the words, we add S, only S. But + +137 +00:12:04,320 --> 00:12:08,040 +for some words which have these endings, okay, you + +138 +00:12:08,040 --> 00:12:12,260 +add what? ES. And the words, and we make the + +139 +00:12:12,260 --> 00:12:17,040 +plural of the nouns and the verbs. Now, what about + +140 +00:12:17,040 --> 00:12:23,680 +toy and buy? You have a noun and a verb. Each one + +141 +00:12:23,680 --> 00:12:29,690 +ends with? Why? The Y is preceded by a vowel. + +142 +00:12:30,290 --> 00:12:34,830 +Okay, the Y is preceded by a vowel. When we add S + +143 +00:12:34,830 --> 00:12:40,510 +to a word ends with Y preceded by a vowel, how do + +144 +00:12:40,510 --> 00:12:47,750 +we write it? Just add. Okay, no change happens. + +145 +00:12:48,330 --> 00:12:52,810 +Just add the S after the Y. Okay? It is preceded + +146 +00:12:52,810 --> 00:12:58,490 +by a vowel. Now, what about baby and cry? They end + +147 +00:12:58,490 --> 00:13:03,530 +with Y. Okay, noun and verb preceded by a + +148 +00:13:03,530 --> 00:13:08,850 +consonant. Okay, thank you. How did we add the S? + +149 +00:13:12,580 --> 00:13:16,300 +Thank you very much. Good. So we change it into + +150 +00:13:16,300 --> 00:13:22,940 +what? I and we add ES. Okay, now please you have + +151 +00:13:22,940 --> 00:13:25,320 +two minutes. Look at your book and do this + +152 +00:13:25,320 --> 00:13:27,040 +exercise. Only two minutes. + +153 +00:13:45,070 --> 00:13:49,730 +Finished? Please check your answers. Check your + +154 +00:13:49,730 --> 00:13:50,130 +answers. + +155 +00:14:16,980 --> 00:14:21,320 +Who got a full mark? Really? Congratulations. + +156 +00:14:21,940 --> 00:14:26,340 +Wonderful. Okay. Do you want to ask about any + +157 +00:14:26,340 --> 00:14:26,780 +point? + +158 +00:14:29,960 --> 00:14:35,820 +Okay. Now look at this rule. Look at this rule. + +159 +00:14:37,840 --> 00:14:41,500 +When we started, we said what? When we started + +160 +00:14:41,500 --> 00:14:47,780 +talking about subject, verb, subject agreement. + +161 +00:14:48,780 --> 00:14:55,300 +What did we say? Yeah, Marwa? Okay, thank you. And + +162 +00:14:55,300 --> 00:14:59,320 +plural? That's right. Can you give me an example? + +163 +00:15:01,120 --> 00:15:04,320 +Singular with singular, plural with plural, yeah? + +164 +00:15:05,980 --> 00:15:08,860 +Ali is a student. Very good. Thank you. Another + +165 +00:15:08,860 --> 00:15:14,840 +example. Yeah. The boys are playing. Very good. + +166 +00:15:15,160 --> 00:15:18,060 +Singular with singular and plural with plural. + +167 +00:15:18,500 --> 00:15:20,700 +That's right. Thank you very much. Now look at + +168 +00:15:20,700 --> 00:15:23,560 +this example. Naveen, could you read the example + +169 +00:15:23,560 --> 00:15:29,280 +please? I have a place in Boston. Again, again, + +170 +00:15:29,400 --> 00:15:33,900 +read it again. Okay. Thank you. My friend lives in + +171 +00:15:33,900 --> 00:15:36,840 +Boston. Thank you. My friend lives in Boston. + +172 +00:15:37,000 --> 00:15:42,500 +Where does your friend live? Again. My friend. My + +173 +00:15:42,500 --> 00:15:47,760 +friend. Again. My friend lives in Boston. Where + +174 +00:15:47,760 --> 00:15:54,120 +does your friend live? My friend. Okay. Listen to + +175 +00:15:54,120 --> 00:15:57,860 +me again. Listen to her. My friend lives in + +176 +00:15:57,860 --> 00:15:59,780 +Boston. Where does your friend live? + +177 +00:16:03,290 --> 00:16:06,650 +Okay. Her friend lives in Cairo. Where does your + +178 +00:16:06,650 --> 00:16:11,090 +friend live? Very good. Thank you. My friend lives + +179 +00:16:11,090 --> 00:16:14,150 +in Cairo. Thank you. Where does your friend live? + +180 +00:16:17,810 --> 00:16:21,390 +Okay. Thank you. My friend eats chicken. What does + +181 +00:16:21,390 --> 00:16:26,670 +your friend eat? She eats potato. Thank you. My + +182 +00:16:26,670 --> 00:16:29,290 +friend eats fish. What does your friend eat? + +183 +00:16:33,610 --> 00:16:37,190 +Okay, thank you. My friend works in a factory. + +184 +00:16:37,330 --> 00:16:42,180 +Where does your friend work? In a hospital. Works + +185 +00:16:42,180 --> 00:16:45,000 +in a hospital. Thank you very much. So, my friend + +186 +00:16:45,000 --> 00:16:51,120 +works. This is a singular noun with a singular + +187 +00:16:51,120 --> 00:16:56,340 +verb. Okay. Now, my friend works. My friend works. + +188 +00:16:56,520 --> 00:17:00,080 +My friend lives. Singular with singular. Okay. + +189 +00:17:00,500 --> 00:17:04,920 +What about the plural? Yes, read it please. Read. + +190 +00:17:07,260 --> 00:17:10,280 +Thank you. My friends live in Boston. Where do + +191 +00:17:10,280 --> 00:17:15,840 +your friends live? My friends live in Cairo. Very + +192 +00:17:15,840 --> 00:17:19,000 +good. My friends live in Cairo. Where do your + +193 +00:17:19,000 --> 00:17:23,740 +friends live? My friends live in Gaza. Thank you. + +194 +00:17:24,160 --> 00:17:26,780 +My friends work at school. Where do your friends + +195 +00:17:26,780 --> 00:17:31,420 +work? My friends work at school. Where do your + +196 +00:17:31,420 --> 00:17:37,040 +friends work? Okay, thank you. My friends work in + +197 +00:17:37,040 --> 00:17:41,620 +a hospital. Good. Where do your friends work? + +198 +00:17:43,140 --> 00:17:45,940 +Okay, work in a company. Thank you very much. + +199 +00:17:46,060 --> 00:17:52,180 +Again, plural noun with a plural. Okay, good. Now + +200 +00:17:52,180 --> 00:17:57,770 +look. My brother and sister. My brother and + +201 +00:17:57,770 --> 00:18:02,550 +sister. How many persons? Two. Okay. Singular or + +202 +00:18:02,550 --> 00:18:05,750 +plural? Plural. Okay, thank you. Now, my brother + +203 +00:18:05,750 --> 00:18:12,610 +and sister are live, do, eat, play, live in + +204 +00:18:12,610 --> 00:18:18,180 +Boston. My brother, sister and? okay this is a + +205 +00:18:18,180 --> 00:18:22,880 +group of people it is also plural live in boston + +206 +00:18:22,880 --> 00:18:29,340 +so now we use and to connect one to plural or + +207 +00:18:29,340 --> 00:18:35,280 +three plural singular nouns okay when we use and + +208 +00:18:35,280 --> 00:18:39,970 +to connect singular nouns We, they become what? + +209 +00:18:40,330 --> 00:18:43,910 +Yes, my brother, sister. This is singular and this + +210 +00:18:43,910 --> 00:18:47,530 +is singular. But they are, they make one group. + +211 +00:18:47,870 --> 00:18:51,290 +They become plural. We use and to make a group, + +212 +00:18:51,550 --> 00:18:55,150 +live. They become plural noun and they need a + +213 +00:18:55,150 --> 00:19:02,290 +plural verb. Okay. Now, yes or no? What do you + +214 +00:19:02,290 --> 00:19:04,650 +want? To read? Okay, go on. + +215 +00:19:07,730 --> 00:19:12,430 +Thank you very much. Every man, woman and child + +216 +00:19:12,430 --> 00:19:16,910 +needs love. Now every student in the class has a + +217 +00:19:16,910 --> 00:19:23,330 +book, right? Every student, everyone here is a + +218 +00:19:23,330 --> 00:19:29,130 +student, right? Okay, so with every, look, we use + +219 +00:19:29,130 --> 00:19:34,530 +a singular We use a singular noun. Every student + +220 +00:19:34,530 --> 00:19:41,010 +has a book. Okay? Now every man, woman and child + +221 +00:19:41,010 --> 00:19:46,750 +needs. What type of verb do we use? Yeah? Singular + +222 +00:19:46,750 --> 00:19:50,670 +verb. Very good. We use a singular verb. So now + +223 +00:19:50,670 --> 00:19:56,710 +each the same. Each followed + +224 +00:19:56,710 --> 00:20:01,600 +by. A singular noun. Very good. A singular noun. + +225 +00:20:02,340 --> 00:20:08,760 +Now, each book and magazine is. Each book and + +226 +00:20:08,760 --> 00:20:12,100 +magazine is. It means the book is listed and the + +227 +00:20:12,100 --> 00:20:17,040 +magazine is listed. Now, with each and every, we + +228 +00:20:17,040 --> 00:20:21,680 +use singular nouns and we use what? Singular + +229 +00:20:21,680 --> 00:20:25,100 +verbs. Thank you. Now, look at this sentence. + +230 +00:20:26,980 --> 00:20:29,540 +Yeah, who can read the sentence? Yes, please read + +231 +00:20:29,540 --> 00:20:33,100 +it Khadija. That book on political parties is + +232 +00:20:33,100 --> 00:20:36,840 +interesting. Thank you. That book on political + +233 +00:20:36,840 --> 00:20:40,140 +parties. Where is the verb? Where is the noun and + +234 +00:20:40,140 --> 00:20:44,900 +where is the verb in the sentence? Yes, Dua. The + +235 +00:20:44,900 --> 00:20:49,810 +book noun is the verb. That's right. This is the + +236 +00:20:49,810 --> 00:20:54,210 +book, this is the noun, it is the subject, and is + +237 +00:20:54,210 --> 00:20:58,250 +what? Is the verb. They are separated by a phrase. + +238 +00:20:59,070 --> 00:21:03,530 +Okay? They are separated by a phrase. Does this + +239 +00:21:03,530 --> 00:21:07,790 +interruption affect the agreement between the verb + +240 +00:21:07,790 --> 00:21:12,370 +and the subject? No. Okay? Look, on political + +241 +00:21:12,370 --> 00:21:15,130 +parties, + +242 +00:21:16,420 --> 00:21:19,700 +So we don't look at the phrase, we look at the + +243 +00:21:19,700 --> 00:21:25,300 +noun. Even if it is separated by a phrase. The + +244 +00:21:25,300 --> 00:21:26,920 +other sentence, read it please. + +245 +00:21:31,040 --> 00:21:35,540 +Thank you. The ideas in that book, look, in that + +246 +00:21:35,540 --> 00:21:39,260 +book, this is another prepositional phrase. Okay? + +247 +00:21:39,520 --> 00:21:45,580 +It is another phrase. So this interrupts what? The + +248 +00:21:45,580 --> 00:21:50,120 +subject and the verb, but it doesn't affect the + +249 +00:21:50,120 --> 00:21:55,020 +agreement. Okay? So don't look at the phrase or + +250 +00:21:55,870 --> 00:22:00,190 +the clause or whatever comes between them. You + +251 +00:22:00,190 --> 00:22:03,550 +look at the verb. This is the verb. Ideas are. + +252 +00:22:04,030 --> 00:22:08,210 +Book is. Okay? Yes, look at the noun and look at + +253 +00:22:08,210 --> 00:22:11,650 +the verb. So we say the book is and the ideas are. + +254 +00:22:12,010 --> 00:22:16,690 +Can you read it please? Read. Sometimes a phrase + +255 +00:22:16,690 --> 00:22:22,650 +or a clause separates a subject from itself. Yeah. + +256 +00:22:22,990 --> 00:22:29,750 +These interrupting Structures. Structures do not + +257 +00:22:29,750 --> 00:22:35,590 +affect basic agreement. In the first sentence, the + +258 +00:22:35,590 --> 00:22:41,150 +interrupting prepositional phrase on political + +259 +00:22:41,150 --> 00:22:47,210 +party does not change the fact that the verb is + +260 +00:22:47,210 --> 00:22:50,710 +must agree with the subject clause. Okay, thank + +261 +00:22:50,710 --> 00:22:53,970 +you very much. Thank you. Now, I want to give you + +262 +00:22:53,970 --> 00:22:58,200 +another sentence. Now look at this sentence. + +263 +00:23:03,740 --> 00:23:05,140 +Burning, + +264 +00:23:08,080 --> 00:23:08,460 +rainy, + +265 +00:23:11,760 --> 00:23:12,640 +forests, + +266 +00:23:16,320 --> 00:23:19,960 +cause, causes, + +267 +00:23:29,300 --> 00:23:31,860 +Look at this sentence. Which answer is right? + +268 +00:23:33,400 --> 00:23:36,120 +Which answer is right? Causes burning rainy + +269 +00:23:36,120 --> 00:23:42,020 +forests. Cause or causes? Yes, please. + +270 +00:23:44,780 --> 00:23:51,960 +Cause. Why cause? Because forest is plural. Okay, + +271 +00:23:52,180 --> 00:23:57,510 +now listen. Burning rainy forests. Where is the + +272 +00:23:57,510 --> 00:24:02,510 +subject? Burning the forest, the act of, the + +273 +00:24:02,510 --> 00:24:07,950 +process of, okay? The act of or the process of, we + +274 +00:24:07,950 --> 00:24:11,350 +don't look at forests, okay? Because this is where + +275 +00:24:11,350 --> 00:24:15,250 +is the subject, okay? This is the sub, burning it, + +276 +00:24:15,430 --> 00:24:22,010 +it causes, it causes, okay? It causes, right? + +277 +00:24:22,650 --> 00:24:23,290 +Okay. + +278 +00:24:38,650 --> 00:24:41,190 +Look at the other group of sentences. Naveen, + +279 +00:24:41,250 --> 00:24:43,810 +would you read the first one? The book that I got + +280 +00:24:43,810 --> 00:24:46,490 +from my parents was very interesting. Very good. + +281 +00:24:47,070 --> 00:24:50,170 +The book was very interesting. Which book? + +282 +00:24:53,530 --> 00:24:58,870 +That I got from my parents. That I got from my + +283 +00:24:58,870 --> 00:25:03,230 +parents. This is a clause. This clause describes + +284 +00:25:03,230 --> 00:25:07,720 +the noun. It is an adjective clause. What does the + +285 +00:25:07,720 --> 00:25:11,740 +adjective do? It describes the noun. When I say + +286 +00:25:11,740 --> 00:25:14,340 +wither, what type of wither? You know what type of + +287 +00:25:14,340 --> 00:25:18,460 +wither? I don't know. But when I say cold wither, + +288 +00:25:19,480 --> 00:25:24,540 +cold, this is adjective, described the noun. So + +289 +00:25:24,540 --> 00:25:29,760 +this clause that I got from my parents, okay, + +290 +00:25:30,100 --> 00:25:33,980 +describes the noun. It is an adjective. Clause. + +291 +00:25:34,240 --> 00:25:39,600 +Anyhow, now the book was very interesting. Now the + +292 +00:25:39,600 --> 00:25:44,520 +subject and the verb are interrupted by a clause. + +293 +00:25:45,520 --> 00:25:48,640 +Does this interruption affect the relation between + +294 +00:25:48,640 --> 00:25:52,100 +the subject and the verb? No. Now look, the book + +295 +00:25:52,100 --> 00:25:56,880 +is what? Singular. It needs what? A singular verb. + +296 +00:25:57,380 --> 00:26:00,360 +Thank you. Yes, read the other one please, Murida. + +297 +00:26:04,140 --> 00:26:11,240 +Very good. The books where? Plural and plural. The + +298 +00:26:11,240 --> 00:26:16,180 +noun and the verb are also interrupted by another + +299 +00:26:16,180 --> 00:26:20,700 +adjective clause. I bought at the bookstore. So + +300 +00:26:20,700 --> 00:26:23,700 +this interruption again doesn't affect the + +301 +00:26:23,700 --> 00:26:27,020 +relation or the agreement between the subject and + +302 +00:26:27,020 --> 00:26:32,020 +the verb. Okay. Yes. Yeah, please Khadija read. In + +303 +00:26:32,020 --> 00:26:34,300 +the above sentences, the interrupting adjective + +304 +00:26:34,300 --> 00:26:36,980 +clause don't change the fact that the verb was + +305 +00:26:36,980 --> 00:26:40,840 +aware must agree with the subject box. Okay, thank + +306 +00:26:40,840 --> 00:26:43,860 +you very much. So these adjective clauses don't + +307 +00:26:43,860 --> 00:26:48,880 +change the fact. Okay, good. Now, what do you + +308 +00:26:48,880 --> 00:26:53,480 +think of reading? What do you think of reading? + +309 +00:26:54,840 --> 00:27:00,460 +Yes, please. Reading is interesting. Very good. + +310 +00:27:01,600 --> 00:27:04,740 +Reading is interesting. Yes. What do you think of + +311 +00:27:04,740 --> 00:27:07,840 +reading? Reading is very useful. Reading is very + +312 +00:27:07,840 --> 00:27:10,560 +useful. Thank you. What do you think of walking? + +313 +00:27:11,800 --> 00:27:16,460 +What do you think of walking? Walking makes us + +314 +00:27:16,460 --> 00:27:21,170 +healthy. Is healthy. Very good. Yeah. Walking. + +315 +00:27:21,630 --> 00:27:26,330 +Walking is very interesting. Now walking. It is + +316 +00:27:26,330 --> 00:27:30,890 +like what? Watching. Watching old movies is fun. + +317 +00:27:31,450 --> 00:27:35,930 +This is a gerund. Okay? This is a gerund. Watching + +318 +00:27:35,930 --> 00:27:40,390 +movies is fun. And you know the gerund, this is + +319 +00:27:40,390 --> 00:27:44,130 +the subject of the verb. we say it is it a + +320 +00:27:44,130 --> 00:27:49,010 +singular or a plural noun yes singular we say + +321 +00:27:49,010 --> 00:27:54,110 +watching it is what it is what it is fun it is fun + +322 +00:27:54,110 --> 00:27:58,650 +okay watching is fun walking is fun reading is and + +323 +00:27:58,650 --> 00:28:03,930 +so on so this is again another Singular, it is + +324 +00:28:03,930 --> 00:28:07,510 +treated as a singular noun. It is the subject, we + +325 +00:28:07,510 --> 00:28:12,170 +say this is called a gerund, okay? Infinitive plus + +326 +00:28:12,170 --> 00:28:18,730 +ing and it needs a singular verb. Now we have an + +327 +00:28:18,730 --> 00:28:23,610 +exercise. Three minutes, I'd like you to do the + +328 +00:28:23,610 --> 00:28:27,650 +exercise, okay? Go on please, do this exercise. + +329 +00:28:34,590 --> 00:28:37,070 +Okay, go on. Please check your answers. + +330 +00:28:46,010 --> 00:28:48,330 +Check the answers. Finished? + +331 +00:29:05,230 --> 00:29:12,300 +The last one? Read it, read it please. I love to + +332 +00:29:12,300 --> 00:29:16,040 +go to shopping when I am on vacation, but I don't + +333 +00:29:16,040 --> 00:29:19,480 +buy many things. I love to go shopping. A interest + +334 +00:29:19,480 --> 00:29:22,540 +shopping is cheaply made. Okay, so this is a + +335 +00:29:22,540 --> 00:29:25,280 +group. A lot of the staff, this is a group. One. + +336 +00:29:25,960 --> 00:29:31,520 +Okay? Yeah. One. It is one group, okay? We deal it + +337 +00:29:31,520 --> 00:29:34,300 +as one group. Yes, read it. Number six. The + +338 +00:29:34,300 --> 00:29:37,800 +professor and the student agree or agrees on the + +339 +00:29:37,800 --> 00:29:42,010 +point. Yeah, what do you think? Why agree? Again, + +340 +00:29:42,430 --> 00:29:45,610 +how many? The professor and the student. How many + +341 +00:29:45,610 --> 00:29:48,390 +people? Two. Two. Is it plural or singular? + +342 +00:29:48,850 --> 00:29:52,850 +Plural. Okay, so they agree. They agree, right? + +343 +00:29:53,450 --> 00:29:56,830 +The professor agrees. The student agrees. The + +344 +00:29:56,830 --> 00:30:02,530 +professor and the student agree, okay? Yes please, + +345 +00:30:02,770 --> 00:30:04,930 +read it. Almost every professor agrees. Listen, + +346 +00:30:05,070 --> 00:30:08,150 +listen please. Almost every professor agrees. + +347 +00:30:08,150 --> 00:30:10,690 +Which one you are reading? Seven. Number seven, + +348 +00:30:10,750 --> 00:30:10,910 +yeah. + +349 +00:30:21,180 --> 00:30:27,380 +Now we say every student in the class has a book. + +350 +00:30:28,160 --> 00:30:32,460 +Every student in the class has a book, right? Or + +351 +00:30:32,460 --> 00:30:36,200 +each student has a book, right? Yes, please. Nine. + +352 +00:30:38,210 --> 00:30:42,970 +Tomatoes are easy to grow. Growing tomatoes is + +353 +00:30:42,970 --> 00:30:47,150 +especially easy. Yeah, growing is. Growing is. + +354 +00:30:47,270 --> 00:30:53,450 +Watching is. Reading is. Walking is. Okay? Other + +355 +00:30:53,450 --> 00:30:54,090 +questions? + +356 +00:30:56,790 --> 00:31:01,610 +Other questions? Who got a full mark? Really? + +357 +00:31:02,050 --> 00:31:06,990 +Wonderful. Good number. Wonderful. The last one. + +358 +00:31:07,550 --> 00:31:10,510 +What about the last one? Aha, you asked about it. + +359 +00:31:10,710 --> 00:31:13,230 +Okay, good, never mind. One mistake, next time + +360 +00:31:13,230 --> 00:31:17,330 +you'll get a full mark. Are there any questions on + +361 +00:31:17,330 --> 00:31:18,050 +the exercise? + +362 +00:31:21,190 --> 00:31:23,290 +Are there any questions on the exercise? + +363 +00:31:28,190 --> 00:31:30,450 +Thank you very much. This is enough for today. + +364 +00:31:32,450 --> 00:31:34,050 +This is enough for the lecture. + diff --git a/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/-rwa1tQb068.srt b/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/-rwa1tQb068.srt new file mode 100644 index 0000000000000000000000000000000000000000..0d967416afcce6d78488e15356d3de409baf02ce --- /dev/null +++ b/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/-rwa1tQb068.srt @@ -0,0 +1,1535 @@ +1 +00:00:20,700 --> 00:00:27,360 +بسم الله الرحمن الرحيم in the previous meetings we + +2 +00:00:27,360 --> 00:00:31,940 +defined beta and we said beta is a measure of + +3 +00:00:31,940 --> 00:00:37,660 +systemic risk. Okay, today we are going to estimate + +4 +00:00:37,660 --> 00:00:43,340 +beta and to see how the beta for portfolio is + +5 +00:00:43,340 --> 00:00:48,770 +calculated. Beta could be estimated using Excel. لذلك + +6 +00:00:48,770 --> 00:00:54,950 +الطلاب في الإنتجار المالي سيشاهد كيف يتم تخصيص + +7 +00:00:54,950 --> 00:00:58,730 +بيتا على Excel أو تخصيص مالي أو قادر على الاختيار + +8 +00:00:58,730 --> 00:01:04,890 +من مصادر مختلفة من الإنترنت. إذا كنا نذهب إلى Yahoo + +9 +00:01:04,890 --> 00:01:14,650 +إذا كنا نفتح Yahoo وكما ترى هذا Yahoo وهو + +10 +00:01:14,650 --> 00:01:21,060 +لـ IBM. إذا كنت تنظر إلى، إذا تنظر إلى البيانات لـ + +11 +00:01:21,060 --> 00:01:27,900 +IBM، هنا الـ Closing Price، وهذه الـ Open Price، وهذه + +12 +00:01:27,900 --> 00:01:31,200 +الـ Bid Price، وهذه الـ Ask Price، وهذه الـ Beta. + +13 +00:01:31,200 --> 00:01:46,950 +Beta يقل 0.65. 0.65 يعني أن IBM لديه بيانات أقل. إذا + +14 +00:01:46,950 --> 00:01:55,650 +ارتفع السوق 10%، سيرتفع الـ IBM 6 + +15 +00:01:55,650 --> 00:02:06,710 +.5% لأن الـ Beta 0.65. إذا أردت تخطيط الـ Beta + +16 +00:02:06,710 --> 00:02:11,230 +باستخدام Excel، فانتقل فقط إلى الأسعار التاريخية مثل + +17 +00:02:11,230 --> 00:02:14,110 +هذا. + +18 +00:02:18,860 --> 00:02:22,920 +هذه هي السعر التاريخي للبيتا، خذ السعر التقريبي، + +19 +00:02:22,920 --> 00:02:27,080 +وهذا هو السعر التقريبي ثم + +20 +00:02:27,080 --> 00:02:32,860 +اشتري الـ S&P، هذا هو IBM. + +21 +00:02:36,010 --> 00:02:43,130 +أنت تخطيط عادة IBM، ثم تخطيط عادة S&P500. لماذا S + +22 +00:02:43,130 --> 00:02:49,850 +&P500؟ لأن S&P500، أما الـ IBM موجودة موجودة في شركة + +23 +00:02:49,850 --> 00:02:53,970 +New York Stock Exchange، و S&P500 هو نموذج شركة New + +24 +00:02:53,970 --> 00:03:02,910 +York Stock Exchange. أنت تخطيط الـ R من IBM، و R من S + +25 +00:03:02,910 --> 00:03:12,470 +&P500، ثم تخطيط السلوب. سأريك كيف يعمل. سلوب عودة S + +26 +00:03:12,470 --> 00:03:30,710 +&P500 مختارة من عودة IBM. نحن + +27 +00:03:30,710 --> 00:03:37,600 +لدينا بيتا أكثر من Yahoo Finance لـ Apple, Dell, + +28 +00:03:38,000 --> 00:03:42,260 +HP, American Electronic Power, Duke Energy، و + +29 +00:03:42,260 --> 00:03:48,380 +Center Point Energy. ما نلاحظه إذا حصلنا على بيتا + +30 +00:03:48,380 --> 00:03:53,980 +من Yahoo Finance، لدينا هذه البيتا. ولكن إذا حصلنا + +31 +00:03:53,980 --> 00:03:59,940 +على بيتا من MSN، لدينا هذه البيتا. ما نلاحظه في هذا، + +32 +00:03:59,940 --> 00:04:01,760 +لدينا بيتا مختلفة من مصادر مصادر مصادر مصادر مصادر + +33 +00:04:01,760 --> 00:04:04,040 +مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر + +34 +00:04:04,040 --> 00:04:04,300 +مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر + +35 +00:04:04,300 --> 00:04:08,070 +مصادر مصادر مصادر مصادر مصادر. هذا المشكلة إذا + +36 +00:04:08,070 --> 00:04:12,590 +حصلنا على الـ Ready Beta من المصادر المختلفة. + +37 +00:04:12,590 --> 00:04:15,670 +لماذا؟ + +38 +00:04:15,670 --> 00:04:25,070 +لأنهم يستخدمون فترة مختلفة في الـ Estimate Beta. ما + +39 +00:04:25,070 --> 00:04:29,570 +نلاحظه في إضافة إلى التغيير في Beta بين Yahoo + +40 +00:04:29,570 --> 00:04:35,980 +Finance و Microsoft Money، الكمبيوتر Beta أكبر من الـ + +41 +00:04:35,980 --> 00:04:45,820 +Utility Beta. انظر هنا، Apple 2.9، Dell 1.80، HP 1 + +42 +00:04:45,820 --> 00:04:52,240 +.27، ولكن إذا نظر إلى الـ Utilities، مقارنة مع + +43 +00:04:52,240 --> 00:04:58,540 +الكمبيوتر والسوفتوير، لدينا Beta أقل. Why? Because + +44 +00:04:58,540 --> 00:05:01,460 +computers and softwares are working in the high + +45 +00:05:01,460 --> 00:05:05,100 +risk environments compared to the utilities. + +46 +00:05:05,100 --> 00:05:08,620 +Utilities like the energy companies. So the demand + +47 +00:05:08,620 --> 00:05:11,740 +in the energy companies is lower than the demand + +48 +00:05:11,740 --> 00:05:16,260 +or the risk. The companies working in the computer + +49 +00:05:16,260 --> 00:05:20,400 +and software is subject to higher risk than the + +50 +00:05:20,400 --> 00:05:24,260 +companies working in the energy industries. وهذا + +51 +00:05:24,260 --> 00:05:28,060 +السبب أن بيطة في الكمبيوتر والبرنامج أكبر من + +52 +00:05:28,060 --> 00:05:35,260 +بيطات في الشركات المستخدمة، حسنًا؟ هل لديك أسئلة؟ + +53 +00:05:35,260 --> 00:05:41,740 +بالتأكيد؟ حسنًا، إذا نظرنا مرة أخرى إلى الطابق 8 + +54 +00:05:41,740 --> 00:05:46,180 +نلاحظ + +55 +00:05:46,180 --> 00:05:50,020 +أن الشركات المستخدمة لديها بيطات أقل. + +56 +00:05:53,720 --> 00:06:04,240 +How we calculate beta by using formulas if + +57 +00:06:04,240 --> 00:06:11,140 +we have if + +58 +00:06:11,140 --> 00:06:14,880 +we have observation about the return of IBM or the + +59 +00:06:14,880 --> 00:06:19,380 +return of Dell، والتحقيق من السوق، السوق تم تحقيقه + +60 +00:06:19,380 --> 00:06:25,660 +من S&P500، لدينا التحقيق هنا وتحقيق هنا، حسنًا؟ + +61 +00:06:25,660 --> 00:06:34,600 +لذلك، قررنا بيتا هو التغيير في عدد التحقيق لأن + +62 +00:06:34,600 --> 00:06:42,200 +التغيير في تحقيق السوق أو بطريقة أخرى، تحقيق + +63 +00:06:42,200 --> 00:06:51,630 +Dell من التغيير من عودة السوق. إذا قمنا بتوصيل هذا + +64 +00:06:51,630 --> 00:07:02,090 +باستخدام مقارنة، إذا كنا باستخدام مقارنة، لدينا + +65 +00:07:02,090 --> 00:07:07,650 +هذه المقارنة، هذا + +66 +00:07:07,650 --> 00:07:16,430 +الواقع X هو عودة السوق، والواقع Y هو دولة. هذا Dim + +67 +00:07:16,430 --> 00:07:21,850 +وهذا عودة السوق. حسنًا، + +68 +00:07:21,850 --> 00:07:25,530 +فالبيتا + +69 +00:07:25,530 --> 00:07:29,490 +الآن هي أسلوب هذه + +70 +00:07:29,490 --> 00:07:35,590 +الاتصالات. وكيف يمكننا تخيل أسلوبها؟ أسلوب هذه + +71 +00:07:35,590 --> 00:07:41,790 +المنطقة تم تخيله باستخدام Tan θ. Tan θ هي + +72 +00:07:41,790 --> 00:07:44,130 +ارتفاع مقطع الرأس. + +73 +00:07:50,420 --> 00:07:53,820 +Okay, this is we can estimate this by using Excel + +74 +00:07:53,820 --> 00:08:00,500 +sheet. Just put in the Excel, do slope, then put the + +75 +00:08:00,500 --> 00:08:10,660 +Rm then Ri's, you will get the beta. This is in the + +76 +00:08:10,660 --> 00:08:21,110 +Excel sheet. Tan θ, this is θ, rise divided by + +77 +00:08:21,110 --> 00:08:29,130 +run. Run المقابل عن المجاور. هذا توجيه ولا لا؟ Just + +78 +00:08:29,130 --> 00:08:36,770 +to remind you if + +79 +00:08:36,770 --> 00:08:43,160 +this is for Dell. هذا لهم. إذا كان لدينا شركة أخرى، + +80 +00:08:43,160 --> 00:08:50,400 +دعونا نقول إذا قمنا بإضافة طاقة، + +81 +00:08:50,400 --> 00:08:55,940 +على سبيل المثال، شركة طاقة، ولدينا الملاحظة، سنقوم + +82 +00:08:55,940 --> 00:09:00,960 +بالمقارنة R من شركة طاقة مع Rm، وسيكون لدينا مثل + +83 +00:09:00,960 --> 00:09:05,400 +هذا. ما + +84 +00:09:05,400 --> 00:09:11,820 +نلاحظه، السلوب من هذا أعلى من السلوب من هذا. يعني أن + +85 +00:09:11,820 --> 00:09:17,900 +بيتا من Dell أعلى من بيتا من... انظر إلى السلوب. + +86 +00:09:17,900 --> 00:09:24,960 +السلوب... السلوب من Tan θ. هنا θ هنا أقل من + +87 +00:09:24,960 --> 00:09:30,720 +θ هنا. θ هي الزاوية، فالثيتا هنا أقل من θ + +88 +00:09:30,720 --> 00:09:41,360 +هنا. لذلك السلوب والبيتا of R energy is less than + +89 +00:09:41,360 --> 00:09:49,840 +the slope of of Dell. Okay, this + +90 +00:09:49,840 --> 00:09:57,480 +is by using the chart, okay. + +91 +00:10:10,800 --> 00:10:19,320 +Slope is equal to tan θ. Tan θ tan θ + +92 +00:10:19,320 --> 00:10:22,680 +Okay. + +93 +00:10:22,680 --> 00:10:33,300 +Rise divided by run. Rm divided by Ri, but + +94 +00:10:33,300 --> 00:10:36,840 +this is for the beta for the individual stock. + +95 +00:10:39,300 --> 00:10:44,880 +العادة من السوق، را را را را را را را را را را را + +96 +00:10:44,880 --> 00:10:47,120 +را را را را را را را را را را را را را را را را + +97 +00:10:47,120 --> 00:10:47,300 +را را را را را را را را را را را را را را را را + +98 +00:10:47,300 --> 00:10:48,880 +را را را را را را را را را را را را را را را را + +99 +00:10:48,880 --> 00:10:49,360 +را را را را را را را را را را را را را را را را + +100 +00:10:49,360 --> 00:11:04,460 +را را را را را را را را را را را + +101 +00:11:04,460 --> 00:11:06,520 +ر + +102 +00:11:09,400 --> 00:11:15,520 +The beta of portfolio is equal to the proportion + +103 +00:11:15,520 --> 00:11:22,440 +of beta for each stock. So it is w1 times beta of + +104 +00:11:22,440 --> 00:11:30,260 +the stock number one plus w2 beta two plus wn beta + +105 +00:11:30,260 --> 00:11:36,440 +n. Okay, so this is the beta of portfolio. + +106 +00:11:41,390 --> 00:11:43,490 +على سبيل المثال، إذا كان لدينا مثلًا مثلًا مثلًا + +107 +00:11:43,490 --> 00:11:44,250 +مثلًا مثلًا مثلًا مثلًا مثلًا مثلًا مثلًا مثلًا + +108 +00:11:44,250 --> 00:11:46,370 +مثلًا مثلًا مثلًا مثلن مثلن مثلن مثلن مثلن مثلن + +109 +00:11:46,370 --> 00:11:47,570 +مثلن مثلن مثلن مثلن مثلن مثلن مثلن مثلن مثلن مثلن + +110 +00:11:47,570 --> 00:11:49,530 +مثلن مثلن مثلن مثلن مثلن مثلن مثلن مثلن مثلن مثلن + +111 +00:11:49,530 --> 00:12:10,170 +مثلن مثلن مثلن مثلن مثلن مث + +112 +00:12:10,200 --> 00:12:19,060 +لـ HP هو 1.28$، وانتج + +113 +00:12:19,060 --> 00:12:30,880 +...انتج... دعونا نقول أننا نستخدم 2000$ في Apple، و + +114 +00:12:30,880 --> 00:12:40,150 +2000$ في Dell، و 1000$ في HP. إذا ما هو الـ Beta؟ وهو + +115 +00:12:40,150 --> 00:12:48,490 +كمية من الـ Portfolio، حسنًا؟ فالآن فقط لكي نتخيل الضغط، + +116 +00:12:48,490 --> 00:12:52,970 +نريد أن نعرف الضغط، لأننا لدينا بيتا هنا، ولكننا لا + +117 +00:12:52,970 --> 00:12:59,930 +نعرف الضغط. الضغط هو 2000 مقال 5000، لأننا نستخدم 5000 + +118 +00:13:03,810 --> 00:13:11,750 +والـ 5000، 2000 في Apple، 2000 في Dell، 1000 في HP. فـ 2000 + +119 +00:13:11,750 --> 00:13:22,010 +مقاطع 5000 هو 40%. 40 + +120 +00:13:22,010 --> 00:13:29,490 +% وهو 40%، وهو 20%. هل هذا صحيح؟ + +121 +00:13:32,410 --> 00:13:40,830 +الآن بيطة بسيطة جدا، فقط هذه، وهذه بيطة المساعدة + +122 +00:13:40,830 --> 00:13:41,290 +المساعدة المساعدة المساعدة المساعدة المساعدة + +123 +00:13:41,290 --> 00:13:43,170 +المساعدة المساعدة المساعدة المساعدة المساعدة + +124 +00:13:43,170 --> 00:13:45,210 +المساعدة المساعدة المساعدة المساعدة المساعدة + +125 +00:13:45,210 --> 00:13:46,150 +المساعدة المساعدة المساعدة المساعدة المساعدة + +126 +00:13:46,150 --> 00:13:54,130 +المساعدة المساعدة المساعدة المساعدة + +127 +00:13:54,130 --> 00:14:01,750 +المس + +128 +00:14:08,570 --> 00:14:16,350 +سهل جدا، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، + +129 +00:14:16,350 --> 00:14:19,090 +نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، + +130 +00:14:19,090 --> 00:14:20,850 +نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، + +131 +00:14:20,850 --> 00:14:21,410 +نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، + +132 +00:14:21,410 --> 00:14:27,450 +نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، + +133 +00:14:27,450 --> 00:14:30,990 +نعم، نعم، نعم، نعم، نعم + +134 +00:14:38,900 --> 00:14:44,740 +ما هو النتيجة؟ 1.93 + +135 +00:14:44,740 --> 00:14:52,040 +مليون دولار. حسنًا، دعونا نسألكم سؤال صغير. إذا كنت + +136 +00:14:52,040 --> 00:14:59,660 +أرغب في إزالة بيطة هذا الوصف، ما يمكنني فعله؟ إذا + +137 +00:14:59,660 --> 00:15:01,040 +كنت أرغب في إزالة بيطة هذا الوصف، ما يمكنني فعله؟ + +138 +00:15:01,040 --> 00:15:02,280 +إذا كنت أرغب في إزالة بيطة هذا الوصف، ما يمكنني + +139 +00:15:02,280 --> 00:15:07,440 +فعله؟ إذا كنت أرغب في إضافة بيطة لهذا الـ Portfolio، + +140 +00:15:07,440 --> 00:15:11,820 +لأن كما قلنا إنهم يتعاملون ببيطة ويعاملون عدد + +141 +00:15:11,820 --> 00:15:15,900 +التعامل إذا كنت أرغب في إضافة بيطة لهذا + +142 +00:15:15,900 --> 00:15:22,020 +البرتفاليون لذا ماذا يمكنني فعله؟ إضافة + +143 +00:15:22,020 --> 00:15:25,720 +دل + +144 +00:15:31,430 --> 00:15:37,610 +أو إزالة أبل؟ نعم سوف نزال أبل لأنها لديها بيطة + +145 +00:15:37,610 --> 00:15:41,470 +أكبر منها فالبيطة + +146 +00:15:41,470 --> 00:15:45,430 +في الميزانية ستزال أكبر، نعم أنت محق، لكن إذا أردت + +147 +00:15:45,430 --> 00:15:53,020 +أن أزيل بيطة، ميزانية البيطة، ماذا يمكنني فعل؟ أو + +148 +00:15:53,020 --> 00:16:00,020 +HP لذلك سأزيد المشاركة لـ DELL لذلك دعنا + +149 +00:16:00,020 --> 00:16:05,700 +نعود إلى مفهومنا لـ Beta Beta هو مقارنة من المخاطر + +150 +00:16:05,700 --> 00:16:11,700 +السيستمية ومقارنة من المشاركة لكل أمن في المخاطر + +151 +00:16:11,700 --> 00:16:16,540 +السيستمية لذلك كما نشاهد في هذا المثال هنا نشاهد + +152 +00:16:16,540 --> 00:16:22,580 +أن إذا أزدنا المشاركة الأعلى للسوق البرتفاليو + +153 +00:16:22,580 --> 00:16:29,820 +بيتا أو البرتفوليو بيتا البرتفوليو بيتا + +154 +00:16:29,820 --> 00:16:31,400 +البرتفوليو بيتا البرتفوليو بيتا البرتفوليو بيتا + +155 +00:16:31,400 --> 00:16:31,940 +البرتفوليو بيتا البرتفوليو بيتا البرتفوليو بيتا + +156 +00:16:31,940 --> 00:16:32,020 +البرتفوليو بيتا البرتفوليو بيتا البرتفوليو بيتا + +157 +00:16:32,020 --> 00:16:36,980 +البرتفوليو بيتا البرتفوليو + +158 +00:16:36,980 --> 00:16:41,880 +بيتا البرتفوليو بيتا البرتفوليو بيتا + +159 +00:16:58,880 --> 00:17:06,180 +أنت تذهب إلى ال .. أين هو .. نعم تزيد عمليات ال + +160 +00:17:06,180 --> 00:17:06,940 +beta للأسفل + +161 +00:17:21,890 --> 00:17:26,910 +Okay so this is typically what the formula is the + +162 +00:17:26,910 --> 00:17:30,490 +proportion of portfolio investment in asset one + +163 +00:17:30,490 --> 00:17:34,630 +beta of asset one the proportion of asset two beta + +164 +00:17:34,630 --> 00:17:42,820 +till the look at the W and beta okay اعتبر هذا + +165 +00:17:42,820 --> 00:17:47,560 +المثال هنا هو مشابه لمثالنا اعتبر بورفوليو مجتمع + +166 +00:17:47,560 --> 00:17:51,780 +من أربع استثمار مع بيتاس مرتفعة لذا لدينا أربع + +167 +00:17:51,780 --> 00:18:04,980 +استثمار أربع استثمار 1.5 البيتاس 1.5.75 1.80 و 0.60 + +168 +00:18:04,980 --> 00:18:12,620 +إذا استثميت مرتفع In each investment what will be + +169 +00:18:12,620 --> 00:18:17,700 +the beta for the portfolio؟ So now what is the + +170 +00:18:17,700 --> 00:18:21,240 +way؟ + +171 +00:18:21,240 --> 00:18:28,300 +Yes As in here if we invest equal amount in each + +172 +00:18:28,300 --> 00:18:30,780 +investment what will be the beta for the + +173 +00:18:30,780 --> 00:18:40,350 +portfolio؟ صحيح 25% نعم صحيح 25% 25% 25% كيف + +174 +00:18:40,350 --> 00:18:47,570 +نستخدمها لأنها تحتوي على نفس الشيء فقط كم أشياء + +175 +00:18:47,570 --> 00:18:50,710 +لدينا احد اثنين اثنين اثنين اثنين اثنين اثنين + +176 +00:18:50,710 --> 00:18:51,790 +اثنين اثنين اثنين اثنين اثنين اثنين اثنين اثنين + +177 +00:18:51,790 --> 00:18:52,190 +اثنين اثنين اثنين اثنين اثنين اثنين اثنين اثنين + +178 +00:18:52,190 --> 00:18:52,610 +اثنين اثنين اثنين اثنين اثنين اثنين اثنين اثنين + +179 +00:18:52,610 --> 00:18:54,030 +اثنين اثنين اثنين اثنين اثنين اثنين اثنين اثنين + +180 +00:18:54,030 --> 00:19:02,110 +اثنين اثنين اثنين اثنين اثنين الطريقة هي بسيطة + +181 +00:19:02,110 --> 00:19:11,990 +فقط إضافة المشاركة 1.5 X 0.25 Plus 0.75 X 0.25 + +182 +00:19:11,990 --> 00:19:21,510 +Plus 1.80 X 0.25 Plus 0.60 X 0.25 ثم ستحصل على + +183 +00:19:21,510 --> 00:19:23,990 +البيتا للميكروفونت + +184 +00:19:33,600 --> 00:19:45,240 +ماذا؟ 1.16 1.16 فـ 1.16% نعم فالنتيجة 1.16 1.16 نعم + +185 +00:19:45,240 --> 00:19:52,080 +بيتا إذا + +186 +00:19:52,080 --> 00:19:58,220 +كان لدينا خمس أمنات ماذا هي المشاركة لكل واحدة؟ 20 + +187 +00:19:58,220 --> 00:19:58,740 +% + +188 +00:20:13,680 --> 00:20:22,360 +أي سؤال؟ حسنًا، هذا هو النتائج 1.16. الآن خطوط + +189 +00:20:22,360 --> 00:20:25,980 +السوق الحماية وCAPM الخطوط السوق الحماية وخطوط + +190 +00:20:25,980 --> 00:20:39,020 +السوق الحماية ما هي + +191 +00:20:39,020 --> 00:20:42,520 +خطوط السوق الحماية؟ بالتالي، باعتبار الـ Efficient + +192 +00:20:42,520 --> 00:20:47,360 +Market Hypothesis باعتبار + +193 +00:20:47,360 --> 00:20:52,440 +الـ Efficient Market Hypothesis كل الأمانات يجب أن + +194 +00:20:52,440 --> 00:20:56,280 +تكون مواجهة في خطة السوق الأمانية، فهذه خطة السوق + +195 +00:20:56,280 --> 00:21:04,810 +الأمانية، إذا كان لدينا شركة A مثلاً إذا كان لدينا + +196 +00:21:04,810 --> 00:21:09,710 +شركات A,B,C هذه الشركات يجب أن تكون مواصلة في + +197 +00:21:09,710 --> 00:21:14,430 +خطوات السحر ماذا + +198 +00:21:14,430 --> 00:21:22,790 +هو الوضع خلف خطوات السحر؟ خطوة السحر هي + +199 +00:21:22,790 --> 00:21:26,890 +مبادرة + +200 +00:21:26,890 --> 00:21:35,600 +على الفكرة أن كل أشياء أو كل سحرتفكير الـ risk and + +201 +00:21:35,600 --> 00:21:42,800 +return فهذا هو الوصف ال risk وهذا هو الوصف ال + +202 +00:21:42,800 --> 00:21:47,780 +return كل + +203 +00:21:47,780 --> 00:21:52,660 +الأمانات يجب أن تكون مواصلة في خطة السوق الأمانية + +204 +00:21:52,660 --> 00:21:59,280 +هناك اتفاق بين ال risk و return هذا باعتبار + +205 +00:21:59,280 --> 00:22:06,400 +الـ Hypothesis المفتوح الشركات المفيدة من الحيوانات + +206 +00:22:06,400 --> 00:22:14,480 +التجارية يعتقدون أن هناك اتفاق بين الضرر والعادة، + +207 +00:22:14,480 --> 00:22:20,440 +لكن الحيوانات التجارية المفقودة تعتقدون أنه لا + +208 +00:22:20,440 --> 00:22:25,410 +يوجد خطوط تجارة الأمان أو أن الأمانات ليست موظفة في + +209 +00:22:25,410 --> 00:22:31,170 +خطة السوق الساقية، فهناك مقارنة. على سبيل المثال، + +210 +00:22:31,170 --> 00:22:35,050 +إذا كنا ننظر إلى A باعتبار مفارقة السوق الساقية، + +211 +00:22:35,050 --> 00:22:46,490 +فهي مقارنة ضد اعتبار السوق الساقية باعتبار مفارقة + +212 +00:22:46,490 --> 00:22:51,590 +السوق الساقية. ولكن اعتقاد المحادثات عن المحادثات + +213 +00:22:51,590 --> 00:22:51,870 +عن المحادثات عن المحادثات عن المحادثات عن + +214 +00:22:51,870 --> 00:22:52,590 +المحادثات عن المحادثات عن المحادثات عن المحادثات + +215 +00:22:52,590 --> 00:22:55,990 +عن المحادثات عن المحادثات عن المحادثات عن + +216 +00:22:55,990 --> 00:22:57,270 +المحادثات عن المحادثات عن المحادثات عن المحادثات + +217 +00:22:57,270 --> 00:22:58,110 +عن المحادثات عن المحادثات عن المحادثات عن + +218 +00:22:58,110 --> 00:22:59,590 +المحادثات عن المحادثات عن المحادثات عن المحادثات + +219 +00:22:59,590 --> 00:23:00,430 +عن المحادثات عن المحادثات عن المحادثات عن + +220 +00:23:00,430 --> 00:23:00,690 +المحادثات عن المحادثات عن المحادثات عن المحادثات + +221 +00:23:00,690 --> 00:23:06,250 +عن المحادثات عن المحادثات عن المحادثات عن + +222 +00:23:06,250 --> 00:23:16,430 +المحادثات عن المحادثات عن المحادثات + +223 +00:23:16,430 --> 00:23:16,530 +عن المح + +224 +00:23:19,540 --> 00:23:25,020 +إذا بدأنا هنا هذا خطر حر، فالخطر يقوم بالإيقاع 0 + +225 +00:23:25,020 --> 00:23:36,980 +فالخطر هو 0 وخطر الخطر الحر هو دعنا نقول 6% الخطر + +226 +00:23:36,980 --> 00:23:43,280 +هو 0 وعند خطر 0 الترجمة هي 6% حسنًا دعنا نتحرك إلى + +227 +00:23:43,280 --> 00:23:55,370 +الأعلى لننقل للأعلى، لننظر إلى A إذا نظرنا إلى A ثم + +228 +00:23:55,370 --> 00:24:04,350 +كما نرى، هذه المنطقة غير مخاطرة، وهذه + +229 +00:24:04,350 --> 00:24:08,790 +المنطقة غير مخاطرة + +230 +00:24:12,060 --> 00:24:15,640 +هذا اللي تحت السيستماتيك هذا السيستماتيك وهذا + +231 +00:24:15,640 --> 00:24:20,220 +السيستماتيك لأن السيستماتيك لأن السيستماتيك لأن + +232 +00:24:20,220 --> 00:24:20,840 +السيستماتيك لأن السيستماتيك لأن السيستماتيك لأن + +233 +00:24:20,840 --> 00:24:21,560 +السيستماتيك لأن السيستماتيك لأن السيستماتيك لأن + +234 +00:24:21,560 --> 00:24:22,520 +السيستماتيك لأن السيستماتيك لأن السيستماتيك لأن + +235 +00:24:22,520 --> 00:24:26,880 +السيستماتيك لأن السيستماتيك لأن السيستماتيك لأن + +236 +00:24:26,880 --> 00:24:29,540 +السيستماتيك لأن السيستماتيك لأن السيستماتيك لأن + +237 +00:24:29,540 --> 00:24:29,960 +السيستماتيك لأن السيستماتيك لأن السيستماتيك لأن + +238 +00:24:29,960 --> 00:24:39,660 +السيستماتيك لأن السيست + +239 +00:24:40,020 --> 00:24:43,340 +risk with this return and this is called risk + +240 +00:24:43,340 --> 00:24:50,060 +premium okay + +241 +00:24:50,060 --> 00:24:56,600 +how we estimate a to + +242 +00:24:56,600 --> 00:25:04,860 +estimate a so ra is equal to rf this rf we know + +243 +00:25:04,860 --> 00:25:11,810 +what is rf plus لأن هذا موجود في اللحظة، لذلك نريد + +244 +00:25:11,810 --> 00:25:18,090 +أن نعرف أسلوب هذه اللحظة، لذلك بيتا، أسلوب هذه + +245 +00:25:18,090 --> 00:25:27,830 +اللحظة هي الفرق بين الـ RM، هذا RM مانس RM، + +246 +00:25:27,830 --> 00:25:34,130 +ماركت رتن مانس الـ Risk Free، هذا ماركت رتن، + +247 +00:25:34,130 --> 00:25:39,030 +انظر هنا، هذا ماركت رتن، وهذه المنطقة المخصصة + +248 +00:25:39,030 --> 00:25:43,510 +للمخاطر لذلك لدينا هذه المنطقة هذه المنطقة هي + +249 +00:25:43,510 --> 00:25:50,470 +المخاطر المخصصة انظر في الشارت هذا في الرقم الأحمر + +250 +00:25:50,470 --> 00:25:56,910 +مجموعة + +251 +00:25:56,910 --> 00:26:02,110 +A لأنه موجود في المجموعة المخصصة أو في المجموعة + +252 +00:26:02,110 --> 00:26:04,970 +الخاصة المخصصة المخصصة الـ RF + +253 +00:26:06,570 --> 00:26:14,190 +بسبب أن الـRf هو الوضع التجريبي لذا لدينا فقط هذا، + +254 +00:26:14,190 --> 00:26:19,230 +فهذه الخطوة مناسبة هذه الخطوة لدينا هذه الخطوة، + +255 +00:26:19,230 --> 00:26:24,670 +نسمي هذه الخطوة Risky Premium ببساطة المشاركة هنا، + +256 +00:26:24,670 --> 00:26:32,630 +هذا Risky Premium، هذا بيتا هو السلوك، هذا الـRf هو + +257 +00:26:32,630 --> 00:26:33,050 +ME + +258 +00:26:36,490 --> 00:26:46,330 +التحقيق لـ A يقل لـ risk-free plus beta times risk + +259 +00:26:46,330 --> 00:26:54,990 +premium هذه المشاركة تسمى كمبيوتر أساتذة قيمة هذا + +260 +00:26:54,990 --> 00:26:59,350 +المقارنة تسمى كمبيوتر أساتذة قيمة + +261 +00:27:05,850 --> 00:27:17,390 +هل لدي سؤال؟ لا؟ نعم؟ لا؟ حسنًا + +262 +00:27:17,390 --> 00:27:22,930 +إذا شغلنا في .. في اتصالين أو دعنا نقول في اتصالين + +263 +00:27:22,930 --> 00:27:32,910 +اثنين إذا شغلنا في اتصالين اثنين في A نعتبر A + +264 +00:27:32,910 --> 00:27:33,530 +مصادر خطر + +265 +00:27:38,660 --> 00:27:47,760 +نحن نعتبر A أساتذة خطرية ودعونا نرى لماذا Y هي + +266 +00:27:47,760 --> 00:28:03,760 +أساتذة خطرية هذا هو السبب Y هو خطر خفيف الآن + +267 +00:28:03,760 --> 00:28:13,680 +سؤال واحد ماذا هو بيطة الـ Risk Free؟ ماذا هو بيطة + +268 +00:28:13,680 --> 00:28:24,180 +الـ Risk Free Asset؟ Zero لأنها Zero فهي Zero ماذا + +269 +00:28:24,180 --> 00:28:35,960 +هو Return الـ Risk Free؟ 6% نعم 6% الآن إذا دفعنا إذا + +270 +00:28:35,960 --> 00:28:39,680 +قمنا بإصلاح مواصلة مواصلة، انظر إلى هذه المواصلة، + +271 +00:28:39,680 --> 00:28:43,100 +إذا كنا نقوم بالاستثمار في مواصلة مواصلة مواصلة + +272 +00:28:43,100 --> 00:28:45,400 +مواصلة مواصلة مواصلة مواصلة مواصلة مواصلة مواصلة + +273 +00:28:45,400 --> 00:28:45,780 +مواصلة مواصلة مواصلة مواصلة مواصلة مواصلة مواصلة + +274 +00:28:45,780 --> 00:28:46,120 +مواصلة مواصلة مواصلة مواصلة مواصلة مواصلة مواصلة + +275 +00:28:46,120 --> 00:28:48,240 +مواصلة مواصلة مواصلة مواصلة مواصلة مواصلة مواصلة + +276 +00:28:48,240 --> 00:28:49,720 +مواصلة مواصلة مواصلة مواصلة مواصلة مواصلة مواصلة + +277 +00:28:49,720 --> 00:28:56,760 +مواصلة مواصلة مواصلة مواصلة مواصلة مواصلة مواصلة م + +278 +00:29:19,770 --> 00:29:27,470 +Okay؟ So The + +279 +00:29:27,470 --> 00:29:30,290 +return of portfolio or the expected return of this + +280 +00:29:30,290 --> 00:29:34,510 +portfolio is equal to risk-free + +281 +00:29:38,480 --> 00:29:51,960 +plus the weight average of RM minus RF the + +282 +00:29:51,960 --> 00:29:59,660 +weight average of RM minus RF this area why + +283 +00:29:59,660 --> 00:30:03,840 +exclude the weight average of RF because it is + +284 +00:30:03,840 --> 00:30:04,100 +zero + +285 +00:30:08,380 --> 00:30:15,960 +فالصيغة كانت مثلًا Rf plus W of Rn for the beta + +286 +00:30:15,960 --> 00:30:25,120 +plus W of Rn minus Rf this + +287 +00:30:25,120 --> 00:30:28,460 +is for the risky assets and this is for non-risky + +288 +00:30:28,460 --> 00:30:34,520 +assets for non-risky assets is equal to zero. + +289 +00:30:34,520 --> 00:30:55,180 +نتركها فقط لدينا هذه المقارنة فقط نتركها + +290 +00:30:55,180 --> 00:31:00,240 +فقط لدينا هذه المقارنة + +291 +00:31:00,240 --> 00:31:00,580 +فقط نتركها فقط نتركها فقط + +292 +00:31:03,670 --> 00:31:13,890 +حسنًا، فإننا نشرح الـ CAPM نظر + +293 +00:31:13,890 --> 00:31:17,030 +إلى إعادة الميزانية المتوقعة هي الـ Risk-free plus + +294 +00:31:17,030 --> 00:31:23,430 +الطريقة من منحنى الميزانية، إعادة الميزانية minus + +295 +00:31:23,430 --> 00:31:28,370 +RF حسنًا، + +296 +00:31:28,370 --> 00:31:35,020 +فنشرح هذا الشارتهذا 6% هو الريسك فري وهذا + +297 +00:31:35,020 --> 00:31:41,880 +مجموعه السوق ونقوم فقط بتكليف بيتا هنا هذا ما هو + +298 +00:31:41,880 --> 00:31:49,860 +هذه المنطقة؟ ريسك بريميوم وكيف نقوم بتكليف بيتا؟ + +299 +00:31:49,860 --> 00:31:58,120 +فقط لتذكرك بيتا هي تان θ تان θ + +300 +00:32:00,930 --> 00:32:06,550 +rise divided by run this area divided by this area + +301 +00:32:06,550 --> 00:32:12,650 +okay you can do it in excel or you can do it in + +302 +00:32:12,650 --> 00:32:19,110 +calculator because + +303 +00:32:19,110 --> 00:32:24,370 +it is in here slope rise divided by run this is + +304 +00:32:24,370 --> 00:32:29,410 +the slope of this okay + +305 +00:32:30,430 --> 00:32:37,190 +المنحدر لهذا الزاوية هي هذه المنطقة مقابل هذه + +306 +00:32:37,190 --> 00:32:41,530 +المنطقة، ما المقابل فيهم، وما المقابل لازم نعرف + +307 +00:32:41,530 --> 00:32:46,910 +مقابل الزاوية، وما الزاوية لازم نعرف مقابل الزاوية، و + +308 +00:32:46,910 --> 00:32:48,170 +نعرف مقابل الزاوية، وما الزاوية لازم نعرف مقابل + +309 +00:32:48,170 --> 00:32:49,550 +الزاوية، وما الزاوية لازم نعرف مقابل الزاوية، و لا + +310 +00:32:49,550 --> 00:32:51,470 +زاوية لازم نعرف مقابل الزاوية، و لا زاوية لازم نعرف + +311 +00:32:51,470 --> 00:32:57,610 +مقابل الزاوية، و لا زاوية لازم نعرف مقابل الز + +312 +00:32:59,220 --> 00:33:05,460 +الرحيل هو المجاور، فهذه المنطقة مختلفة من هذه + +313 +00:33:05,460 --> 00:33:10,480 +المنطقة، فهي 8% من هذه المنطقة، آسف 6% إلى 8% + +314 +00:33:10,480 --> 00:33:20,460 +مقارنة بشيء 0.03 مقارنة ب0.6، هذا 0.6 وهذا 0.3، + +315 +00:33:20,460 --> 00:33:29,060 +فهذا 0.6 وهذا 0.3 أو ثلاثة اختر فقط اختر هذا و + +316 +00:33:29,060 --> 00:33:31,060 +اختر هذا واختر هذا واختر هذا واختر هذا و + +317 +00:33:31,060 --> 00:33:31,240 +اختر هذا واختر هذا واختر هذا واختر هذا واختر + +318 +00:33:31,240 --> 00:33:33,340 +هذا واختر هذا واختر هذا واختر هذا واختر هذا + +319 +00:33:33,340 --> 00:33:34,920 +واختر هذا واختر هذا واختر هذا واختر هذا واختر + +320 +00:33:34,920 --> 00:33:37,380 +هذا واختر هذا واختر هذا واختر هذا واختر هذا + +321 +00:33:37,380 --> 00:33:42,460 +واختر هذا واختر هذا واختر هذا واختر هذا واختر + +322 +00:33:42,460 --> 00:33:42,520 +هذا واختر هذا واختر هذا واختار هذا واختار هذا + +323 +00:33:42,520 --> 00:33:43,140 +واختر هذا واختار هذا واختار هذا واختار هذا واختار + +324 +00:33:43,140 --> 00:33:46,060 +هذا واختار هذا واختار هذا واختار هذا واختار هذا + +325 +00:33:46,060 --> 00:33:51,060 +واختر هذا واخت + +326 +00:33:59,410 --> 00:34:04,830 +عودة إلى فكرة نفسنا إذا + +327 +00:34:04,830 --> 00:34:14,610 +كان لدينا اختيار أن نستخدم 100% في الأصول أو في + +328 +00:34:14,610 --> 00:34:16,330 +الأصول الخاصة في الأصول الخاصة في الأصول + +329 +00:34:16,330 --> 00:34:17,810 +الخاصة في الأصول الخاصة في الأصول الخاصة في + +330 +00:34:17,810 --> 00:34:18,370 +الخاصة في الأصول الخاصة في الأصول الخاصة في + +331 +00:34:18,370 --> 00:34:18,610 +الخاصة في الأصول الخاصة في الأصول الخاصة في + +332 +00:34:18,610 --> 00:34:18,810 +الخاصة في الأصول الخاصة في الأصول الخاصة في + +333 +00:34:18,810 --> 00:34:18,850 +الخاصة في الأصول الخاصة في الأصول الخاصة في + +334 +00:34:18,850 --> 00:34:19,950 +الخاصة في الأصول الخاصة في الأصول الخاصة في + +335 +00:34:19,950 --> 00:34:30,270 +الأصول الخاصة في إذا قررنا إضافة أصول خطر للوصف + +336 +00:34:30,270 --> 00:34:37,450 +بمثال 20% فهذا + +337 +00:34:37,450 --> 00:34:48,210 +خطر وهذا خطر، فكيف يتأثر بيتا؟ بيتا ستزيد + +338 +00:34:50,810 --> 00:34:57,210 +Okay if we add more risky assets the beta increases + +339 +00:34:57,210 --> 00:35:05,230 +if we look at R R for instance is 6% so it will + +340 +00:35:05,230 --> 00:35:12,270 +increase and so on if we invest all our money on + +341 +00:35:12,270 --> 00:35:17,910 +the risky assets بيتا سيزداد وعادة تزداد عادة + +342 +00:35:17,910 --> 00:35:22,730 +تزداد عادة تزداد ولا يوجد بيتا بدون نقطة نعم حسنًا + +343 +00:35:22,730 --> 00:35:29,630 +انظر إلى ما قلته هنا هو موضح في هذا الشارع حسنًا + +344 +00:35:29,630 --> 00:35:33,350 +نحن لدينا اختيارين عندما أتكلم عن ماركت بورتفوليو + +345 +00:35:33,350 --> 00:35:38,480 +ماركت بورتفوليو هو هذا ماركت بورتفوليو هذا هو + +346 +00:35:38,480 --> 00:35:42,000 +مجموعة الأسعار الموجودة في الأسعار تعتبر مجموعة + +347 +00:35:42,000 --> 00:35:44,280 +الأسعار الموجودة في الأسعار موجودة في الأسعار + +348 +00:35:44,280 --> 00:35:45,940 +موجودة في الأسعار موجودة في الأسعار موجودة في + +349 +00:35:45,940 --> 00:35:46,440 +الأسعار موجودة في الأسعار موجودة في الأسعار موجودة + +350 +00:35:46,440 --> 00:35:47,780 +في الأسعار موجودة في الأسعار موجودة في الأسعار + +351 +00:35:47,780 --> 00:35:48,800 +موجودة في الأسعار موجودة في الأسعار موجودة في + +352 +00:35:48,800 --> 00:35:50,200 +الأسعار موجودة في الأسعار موجودة في الأسعار موجودة + +353 +00:35:50,200 --> 00:35:50,300 +في الأسعار موجودة في الأسعار موجودة في الأسعار + +354 +00:35:50,300 --> 00:35:54,560 +موجودة + +355 +00:35:54,560 --> 00:36:04,760 +في الأسعار موجودة في الأسعار موجودة في الأسعار موج + +356 +00:36:06,160 --> 00:36:11,240 +100% من المال اللي مستخدمه ريسك فري ثم قيمة + +357 +00:36:11,240 --> 00:36:18,860 +الوظيفة المتوقعة 6% وBeta 0% لأنه إذا وضعنا + +358 +00:36:18,860 --> 00:36:34,220 +المقارنة بـ Beta Portfolio W Beta ريسك فري + +359 +00:36:34,610 --> 00:36:42,390 +فهذا يعني هنا فالخطر صحيح فهو صحيح فهو + +360 +00:36:42,390 --> 00:36:45,890 +صحيح فهو صحيح فهو صحيح فهو صحيح فهو صحيح + +361 +00:36:53,150 --> 00:36:59,230 +20% لـ Portfolio فهذا 80% ريسك مغلق Portfolio 0 + +362 +00:36:59,230 --> 00:37:03,770 +.20% ثم إتجار الإتجار أعلى من السابق الآن فإننا + +363 +00:37:03,770 --> 00:37:08,250 +نزعج هذا المجموعة من المجموعة من الأموال الرئيسية + +364 +00:37:08,250 --> 00:37:17,370 +ماركت بيتا أو آسف Portfolio بيتا 0.4% ثم هذا 8% + +365 +00:37:17,370 --> 00:37:27,560 +حسنًا مرة أخرى 60% ما نشاهده نحن نلاحظ أننا نزعج + +366 +00:37:27,560 --> 00:37:34,740 +الاستثمار في الاستثمار البيتا أكثر والعادة + +367 +00:37:34,740 --> 00:37:40,180 +المتوقعة أكثر وهنا + +368 +00:37:40,180 --> 00:37:49,570 +نستخدم 120% لماذا هو الـ-20%؟ بشكل عام، الفور هو + +369 +00:37:49,570 --> 00:37:59,090 +الـ100% وهذا هو الـ0%، ماذا يعني 120% و-20%؟ لماذا + +370 +00:37:59,090 --> 00:38:03,310 +هذا؟ + +371 +00:38:03,310 --> 00:38:07,150 +حسنًا؟ + +372 +00:38:07,150 --> 00:38:10,630 +نعم؟ لا؟ + +373 +00:38:16,330 --> 00:38:19,790 +this is one hundred percent how it is one hundred + +374 +00:38:19,790 --> 00:38:27,410 +twenty percent sorry okay what exactly here in the + +375 +00:38:27,410 --> 00:38:35,370 +risk-free there is a short sell short selling you + +376 +00:38:35,370 --> 00:38:41,240 +are selling the treasury bills باستخدام صفقات قصيرة + +377 +00:38:41,240 --> 00:38:46,540 +نحن سنتحدث عن هذا في الاستثمار فقط تبقى هذا في + +378 +00:38:46,540 --> 00:38:51,600 +عقبك لخطوات الاستثمار لماذا هذا مقل من 20%؟ أنا + +379 +00:38:51,600 --> 00:38:56,660 +لست أسألك عن هذا في .. في تقرير التداول التداول + +380 +00:38:56,660 --> 00:39:00,280 +التداول؟ حسنًا + +381 +00:39:00,280 --> 00:39:11,130 +نحن نتحدث عن الـ .. الـ CAPM والخطوط التأكيدية Okay + +382 +00:39:11,130 --> 00:39:17,930 +so next meeting we will talk about .. we take some + +383 +00:39:17,930 --> 00:39:21,450 +examples of the expected rate of return and + +384 +00:39:21,450 --> 00:39:26,810 +expected market. Yes okay أعطيكم العامة diff --git a/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/0FwafSm1yrQ_postprocess.srt b/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/0FwafSm1yrQ_postprocess.srt new file mode 100644 index 0000000000000000000000000000000000000000..62735741aa28ae225b4d8abe9470e234e92f5b15 --- /dev/null +++ b/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/0FwafSm1yrQ_postprocess.srt @@ -0,0 +1,1548 @@ +1 +00:00:21,460 --> 00:00:25,760 +بسم الله الرحمن الرحيم اليوم سأتحدث عن مقارنة + +2 +00:00:25,760 --> 00:00:30,160 +الاستثمارات الأخرى في السنة السابقة كنت أتحدث عن + +3 +00:00:30,160 --> 00:00:35,220 +قيمة الـ Net Present Value وقيمة الميزانية العامة + +4 +00:00:35,220 --> 00:00:40,720 +قبل أن أبدأ بالتحدث عن هذا الموضوع من المهم أن + +5 +00:00:40,720 --> 00:00:45,250 +نعرف أسلوب قيمة الـ Net Present Valueوأحد + +6 +00:00:45,250 --> 00:00:50,510 +المقاومات المهمة في قيمة LitPresent هي أنها لا + +7 +00:00:50,510 --> 00:00:55,330 +تتعامل مع الاختلاف بين المجموعات. على سبيل المثال، + +8 +00:00:55,330 --> 00:01:01,940 +إذا كان لدينا اثنين مشروعينالوحدة من المشروع 100 + +9 +00:01:01,940 --> 00:01:06,580 +ألف دولار والمستخدم الأول في المشروع الثانوي 50 + +10 +00:01:06,580 --> 00:01:12,180 +ألف دولار فهو صعب التقار بين المشروع 100 ألف دولار + +11 +00:01:12,180 --> 00:01:17,740 +والمشروع 50 ألف دولار ففي هذه الحالة المعرفة + +12 +00:01:17,740 --> 00:01:22,950 +الماليةprovide with other investment criteria + +13 +00:01:22,950 --> 00:01:29,830 +including the BI profitability index and the IRR + +14 +00:01:29,830 --> 00:01:36,450 +Internal Rate of Return the payback period so we + +15 +00:01:36,450 --> 00:01:45,010 +will talk about these criteria okay so the BI is + +16 +00:01:45,010 --> 00:01:48,820 +similar to the net present valueبقى انستد of + +17 +00:01:48,820 --> 00:01:56,800 +discounted the cash flow the + +18 +00:01:56,800 --> 00:02:01,280 +initial cash flow so this is the cash flow minus + +19 +00:02:01,280 --> 00:02:04,860 +the initial cash flow this is okay so this is the + +20 +00:02:04,860 --> 00:02:10,140 +net present value instead of doing this what we do + +21 +00:02:10,140 --> 00:02:13,660 +is just the cash flow divided by the initial cash + +22 +00:02:13,660 --> 00:02:18,810 +flowوالدفع المالي الذي أعنيه المعرفة بالمعرفة + +23 +00:02:18,810 --> 00:02:24,230 +المعرفة المعرفة المعرفة المعرفة المعرفة المعرفة + +24 +00:02:24,230 --> 00:02:25,630 +المعرفة المعرفة المعرفة المعرفة المعرفة المعرفة + +25 +00:02:25,630 --> 00:02:30,230 +المعرفة المعرفة المعرفة المعرفة المعرفة المعرفة + +26 +00:02:30,230 --> 00:02:30,590 +المعرفة المعرفة المعرفة المعرفة المعرفة المعرفة + +27 +00:02:30,590 --> 00:02:35,150 +المعرفة المعرفة المعرفة المعرفة المعرفة المعرفة + +28 +00:02:35,150 --> 00:02:44,970 +المعرفة المعرفة المع + +29 +00:02:46,480 --> 00:02:51,580 +لأننا لدينا مرتبة من الدولار + +30 +00:02:51,580 --> 00:02:54,620 +الدولار والدولار مرتبط الدولار والدولار مرتبط + +31 +00:02:54,620 --> 00:02:58,440 +الدولار دولار + +32 +00:02:58,440 --> 00:02:58,560 +دولار دولار دولار دولار دولار دولار دولار دولار + +33 +00:02:58,560 --> 00:02:58,720 +دولار دولار دولار دولار دولار دولار دولار دولار + +34 +00:02:58,720 --> 00:02:58,780 +دولار دولار دولار دولار دولار دولار دولار دولار + +35 +00:02:58,780 --> 00:02:58,900 +دولار دولار دولار دولار دولار دولار دولار دولار + +36 +00:02:58,900 --> 00:02:59,120 +دولار دولار دولار دولار دولار دولار دولار دولار + +37 +00:02:59,120 --> 00:02:59,180 +دولار دولار دولار دولار دولار دولار دولار دولار + +38 +00:02:59,180 --> 00:03:02,700 +دولار دولار دولار دولار دولار دولار + +39 +00:03:02,700 --> 00:03:06,920 +دولار دولار دولار دولار دولار دولار + +40 +00:03:06,920 --> 00:03:10,940 +دولار + +41 +00:03:14,310 --> 00:03:17,510 +مرة أخرى، فهذا هو الهجوم المدفع المدفع المدفع + +42 +00:03:17,510 --> 00:03:20,290 +المدفع المدفع المدفع المدفع المدفع المدفع المدفع + +43 +00:03:20,290 --> 00:03:23,090 +المدفع المدفع المدفع المدفع المدفع المدفع المدفع + +44 +00:03:23,090 --> 00:03:26,370 +المدفع المدفع المدفع المدفع المدفع المدفع المدفع + +45 +00:03:26,370 --> 00:03:26,970 +المدفع المدفع المدفع المدفع المدفع المدفع المدفع + +46 +00:03:26,970 --> 00:03:26,990 +المدفع المدفع المدفع المدفع المدفع المدفع المدفع + +47 +00:03:26,990 --> 00:03:30,270 +المدفع المدفع المدفع المدفع المدفع + +48 +00:03:30,270 --> 00:03:36,010 +المدفع المدفع المد + +49 +00:03:36,610 --> 00:03:40,630 +1 plus k raised to the power 2 and cash flow + +50 +00:03:40,630 --> 00:03:44,630 +coming in the end year divided by or discounted by + +51 +00:03:44,630 --> 00:03:53,750 +divided by the initial cash flow okay so this is + +52 +00:03:53,750 --> 00:03:56,110 +profitability index what exactly means + +53 +00:03:56,110 --> 00:04:02,090 +profitability index what is the dollar return or + +54 +00:04:02,090 --> 00:04:02,850 +in other words + +55 +00:04:09,510 --> 00:04:16,310 +ماذا هو عدد العودة؟ ماذا هو عدد عدد عدد عدد عدد + +56 +00:04:16,310 --> 00:04:17,890 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +57 +00:04:17,890 --> 00:04:17,950 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +58 +00:04:17,950 --> 00:04:18,770 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +59 +00:04:18,770 --> 00:04:21,270 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +60 +00:04:21,270 --> 00:04:28,810 +عدد عدد عدد عدد عد + +61 +00:04:29,710 --> 00:04:34,770 +ماذا هو الوصول للـ$1؟ 7% على سبيل المثال أو 8%؟ + +62 +00:04:34,770 --> 00:04:48,790 +هذه هي فكرة الـ Profitability Index وخيار + +63 +00:04:48,790 --> 00:04:56,810 +البيئة الوظيفة مع البيئة الأعلى مقبولوالمشروع مع + +64 +00:04:56,810 --> 00:05:02,090 +الـ lower bi ليس مقبولًا ومقرر + +65 +00:05:02,090 --> 00:05:14,390 +.. مقرر خياراتنا إذا بي أقل واحد، يعني أننا على + +66 +00:05:14,390 --> 00:05:18,590 +الجانب، تعرفين ماذا يعني على الجانب، حسنا؟ + +67 +00:05:22,340 --> 00:05:29,320 +لو بي اكتر من واحد نقبل المشروع لو بي اقل من واحد + +68 +00:05:29,320 --> 00:05:37,140 +نقبل المشروع عندما + +69 +00:05:37,140 --> 00:05:42,060 +بي اكتر من واحد يعني ان قيمة الانتقال الحقيقي اكتر + +70 +00:05:42,060 --> 00:05:45,540 +من + +71 +00:05:45,540 --> 00:05:51,750 +واحدإذا الـ PI هو 1، فقيمة الـ net present value + +72 +00:05:51,750 --> 00:05:57,470 +هي 0، فهي + +73 +00:05:57,470 --> 00:06:01,170 +اقل لـ 0، + +74 +00:06:01,170 --> 00:06:02,610 +لذلك كون حذرا في الأسئلة المختلفة + +75 +00:06:07,030 --> 00:06:11,270 +Okay, so this is the decision criteria of the PI, + +76 +00:06:11,610 --> 00:06:14,210 +if the PI is equal one, we are on the edge, we are + +77 +00:06:14,210 --> 00:06:16,870 +either accept or reject the project, it depends on + +78 +00:06:16,870 --> 00:06:20,750 +the philosophy of the management, if PI is greater + +79 +00:06:20,750 --> 00:06:24,170 +than one, it means the cash inflows is greater + +80 +00:06:24,170 --> 00:06:29,000 +than the initial cashلذلك عندما نقبل المشروع إذا + +81 +00:06:29,000 --> 00:06:31,800 +البيانات أقل من واحدة هذا يعني أن المال خارج + +82 +00:06:31,800 --> 00:06:37,260 +القواعد أو قيمة المبادرة أكبر من المال في القواعد + +83 +00:06:37,260 --> 00:06:43,700 +في هذه الحالة ننجح من المشروع و مرة أخرى جمال + +84 +00:06:43,700 --> 00:06:49,200 +البيانات نستطيع نقل بين مشروعين مختلفين ومشروعين + +85 +00:06:49,200 --> 00:06:53,840 +مختلفين ومشروعين مختلفينOkay, be careful for the + +86 +00:06:53,840 --> 00:06:58,780 +importance of the BI. BI is similar to the + +87 +00:06:58,780 --> 00:07:01,360 +negative present value, but the importance of it + +88 +00:07:01,360 --> 00:07:04,460 +is address the weaknesses of negative present + +89 +00:07:04,460 --> 00:07:10,660 +value. So, we can apply the .. we can drag between + +90 +00:07:10,660 --> 00:07:14,060 +the different projects. Okay. + +91 +00:07:21,520 --> 00:07:24,020 +لذلك مرة أخرى إذا البيانات أقل من واحد فالمشروع + +92 +00:07:24,020 --> 00:07:27,260 +يجب أن يتم إقلاقه إذا كان أقل من واحد فالقيم + +93 +00:07:27,260 --> 00:07:33,360 +الموجودة ستكون مفاجئة حسنا، سنرى هذا المشكلة تخطيط + +94 +00:07:33,360 --> 00:07:38,000 +أفضل مستخدم لـ ProjectLong تعرفين ProjectLong، + +95 +00:07:38,000 --> 00:07:42,440 +الشخص السابق ProjectLong من المتوقع أن يقدم خمس + +96 +00:07:42,440 --> 00:07:47,260 +سنوات من تدخل المال ويتطلب تدخل قيمة أولى 100 ألف + +97 +00:07:47,260 --> 00:07:53,580 +دولارالقيمة المناسبة لتخصيص PI من project long هو + +98 +00:07:53,580 --> 00:07:59,040 +70% هل project long فرصة استثمار جيدة؟ دعونا نعود + +99 +00:07:59,040 --> 00:08:07,200 +إلى project long دعونا نعود لنرى هل هذا project + +100 +00:08:07,200 --> 00:08:07,800 +long؟ + +101 +00:08:21,530 --> 00:08:25,450 +نعم هذا الوضع الوضع الوضع الوضع الوضع الوضع الوضع + +102 +00:08:25,450 --> 00:08:31,190 +الوضع الوضع الوضع الوضع الوضع الوضع + +103 +00:08:31,190 --> 00:08:36,470 +الوضع الوضع الوضع الوضع الوضع الوضع الوضع الوضع + +104 +00:08:36,470 --> 00:08:36,930 +الوضع الوضع الوضع الوضع الوضع الوضع الوضع الوضع + +105 +00:08:36,930 --> 00:08:37,230 +الوضع الوضع الوضع الوضع الوضع الوضع الوضع الوضع + +106 +00:08:37,230 --> 00:08:40,130 +الوضع الوضع الوضع الوضع الوضع الوضع الوضع الوضع + +107 +00:08:40,130 --> 00:08:40,210 +الوضع الوضع الوضع الوضع الوضع الوضع الوضع الوضع + +108 +00:08:40,210 --> 00:08:43,370 +الوضع الوضع + +109 +00:08:43,370 --> 00:08:53,840 +اللذلك لدينا 1,2,3,4,5 وفي السنة الأولى لدينا 70 + +110 +00:08:53,840 --> 00:09:01,340 +,000 وفي السنة الأخرى 30,000,30,000,25,000 و10,000 + +111 +00:09:01,340 --> 00:09:06,180 +إذا أردنا نقل البيانات بسهولة بسهولة بسهولة بسهولة + +112 +00:09:06,180 --> 00:09:11,340 +بسهولة بسهولة بسهولة بسهولة بسهولةinflows divided + +113 +00:09:11,340 --> 00:09:14,880 +by the initial investments so for example 70 + +114 +00:09:14,880 --> 00:09:19,760 +divided by 1 plus 0.17 the discount is raised to + +115 +00:09:19,760 --> 00:09:27,120 +the power 1 30 1.17 raised to the power 2 30 1.17 + +116 +00:09:27,120 --> 00:09:32,980 +raised to the power 3 plus 25 1.17 raised to the + +117 +00:09:32,980 --> 00:09:37,540 +power 4 and + +118 +00:09:39,200 --> 00:09:51,720 +مع 10 1.17 5 مقارنة ب100000$ مقارنة + +119 +00:09:51,720 --> 00:09:57,320 +ب100000$ إذا كانت النتيجة أكبر من 1 سنقبل المشروع + +120 +00:09:57,320 --> 00:10:02,190 +إذا كانت النتيجة أقل من 1إذا كانت النتيجة أقل من + +121 +00:10:02,190 --> 00:10:07,230 +1، فقيمة الـ net present هو نقل، إذا كانت النتيجة + +122 +00:10:07,230 --> 00:10:11,010 +أكبر من 1، فقيمة الـ net present هي 1، لأن هذا + +123 +00:10:11,010 --> 00:10:15,110 +يشبه + +124 +00:10:15,110 --> 00:10:19,800 +قيمة الـ net presentOkay try to do it one point + +125 +00:10:19,800 --> 00:10:25,200 +eighteen one point eighteen one point eighteen one + +126 +00:10:25,200 --> 00:10:27,300 +point eighteen one point eighteen one point + +127 +00:10:27,300 --> 00:10:27,440 +point eighteen one point eighteen one point + +128 +00:10:27,440 --> 00:10:27,460 +point eighteen one point eighteen one point + +129 +00:10:27,460 --> 00:10:27,580 +eighteen one point eighteen one point eighteen one + +130 +00:10:27,580 --> 00:10:27,660 +point eighteen one point eighteen one point + +131 +00:10:27,660 --> 00:10:27,720 +eighteen one point eighteen one point eighteen one + +132 +00:10:27,720 --> 00:10:27,740 +eighteen one point eighteen one point eighteen one + +133 +00:10:27,740 --> 00:10:27,840 +point eighteen one point eighteen one point + +134 +00:10:27,840 --> 00:10:28,560 +eighteen one point eighteen one point eighteen one + +135 +00:10:28,560 --> 00:10:31,780 +point eighteen one point eighteen one point + +136 +00:10:31,780 --> 00:10:37,600 +eighteen one point eighteen one + +137 +00:10:37,600 --> 00:10:38,020 +point eighteen + +138 +00:10:42,750 --> 00:10:46,130 +من المنصة المالية أو من المنصة الدولية من المنصة + +139 +00:10:46,130 --> 00:10:55,110 +الدولية من المنصة + +140 +00:10:55,110 --> 00:11:03,910 +الدولية من المنصة الدولية من المنصة الدولية + +141 +00:11:03,910 --> 00:11:09,710 +من المنصة الدولية من المنصة الدولية من المنصة + +142 +00:11:09,710 --> 00:11:11,590 +الدولية من المنصة الدولية من المنصة الدولية من + +143 +00:11:11,590 --> 00:11:12,630 +المنصة الدولية من المنصة الدولية من المنصة الدولية + +144 +00:11:12,630 --> 00:11:20,800 +المنصة الدولprojects generate 18% okay any + +145 +00:11:20,800 --> 00:11:27,820 +question okay let's go back to the to the project + +146 +00:11:27,820 --> 00:11:36,140 +to the pi and see the answer okay + +147 +00:11:36,140 --> 00:11:40,060 +okay + +148 +00:11:40,060 --> 00:11:42,820 +so the answer is 1.18 + +149 +00:11:50,920 --> 00:11:59,600 +وهذا مثال أخر P&G Pharmaceutical تعتبر انهيارات في + +150 +00:11:59,600 --> 00:12:01,800 +نظام تدخل مادة تدخل مادة تدخل مادة تدخل مادة تدخل + +151 +00:12:01,800 --> 00:12:03,800 +مادة تدخل مادة تدخل مادة تدخل مادة تدخل مادة تدخل + +152 +00:12:03,800 --> 00:12:04,580 +مادة تدخل مادة تدخل مادة تدخل مادة تدخل مادة تدخل + +153 +00:12:04,580 --> 00:12:05,880 +مادة تدخل مادة تدخل مادة تدخل مادة تدخل مادة تدخل + +154 +00:12:05,880 --> 00:12:11,280 +مادة تدخل مادة تدخل مادة تدخل مادة تدخل + +155 +00:12:19,490 --> 00:12:24,750 +الانفصال الأولى هنا هو 50 ألف دولار لذلك نعود إلى + +156 +00:12:24,750 --> 00:12:32,710 +أسلحة Streamline وانفصالنا الأولى هو 50 ألف دولار + +157 +00:12:32,710 --> 00:12:36,090 +ومن + +158 +00:12:36,090 --> 00:12:37,730 +المتوقع أن نقدر نقدر نقدر نقدر نقدر نقدر نقدر نقدر + +159 +00:12:37,730 --> 00:12:38,310 +نقدر نقدر نقدر نقدر نقدر نقدر نقدر نقدر نقدر نقدر + +160 +00:12:38,310 --> 00:12:38,350 +نقدر نقدر نقدر نقدر نقدر نقدر نقدر نقدر نقدر نقدر + +161 +00:12:38,350 --> 00:12:40,690 +نقدر نقدر نقدر نقدر نقدر نقدر نقدر نقدر نقدر نقدر + +162 +00:12:40,690 --> 00:12:40,790 +نقدر نقدر نقدر نقدر نقدر نقدر نقدر نقدر نقدر نقدر + +163 +00:12:40,790 --> 00:12:46,290 +نقدر نقدر نقدر نقدر نقدر نقدر نقدر نقدر نقدر + +164 +00:12:48,550 --> 00:12:51,450 +القانون المالي هو مثل هذا ، لذلك الانيشا دي فيسكت + +165 +00:12:51,450 --> 00:12:58,190 +هي 50 ألف دولار ، لذلك لدينا 50 ألف ، 15 ألف ، 8 ، + +166 +00:12:58,190 --> 00:13:02,630 +10 ، 12 ، 14 و 16 + +167 +00:13:06,760 --> 00:13:11,120 +Okay, so what is the PI if considering that the K + +168 +00:13:11,120 --> 00:13:17,820 +is 10% K is the discounted rate Okay, it's again + +169 +00:13:17,820 --> 00:13:25,840 +very simple and 15 divided 1 plus 10 raised to the + +170 +00:13:25,840 --> 00:13:34,850 +power 1 8000 1.10 raised to the power2 10 1.10 3 + +171 +00:13:34,850 --> 00:13:55,450 +12 1.10 4 14 10 5 16 1.10 6 50 again if + +172 +00:13:55,450 --> 00:13:59,380 +the result is greater than 1نقبل المشروع إذا كان + +173 +00:13:59,380 --> 00:14:09,720 +أقل من 1 نقل المشروع 1.07 فماذا يعني هذا يا فاطمة؟ + +174 +00:14:09,720 --> 00:14:17,580 +هذا يعني أقل من 1 إلى 1، نقبل المشروع من المنصة + +175 +00:14:17,580 --> 00:14:24,500 +الدولية، هل تعرفين ماذا يعني؟كل 1 دولار جمع إلى 1 + +176 +00:14:24,500 --> 00:14:32,520 +.077% نعم انت محق ان تجمع 1 أو 7 ولكن من المنطقة + +177 +00:14:32,520 --> 00:14:39,600 +الدولية إذا كنت اقوم باستخدام 1 دولار فرصتي 7% انه + +178 +00:14:39,600 --> 00:14:46,600 +حسن لكن إذا كنا نقارن هذا مع السابق السابق + +179 +00:14:46,600 --> 00:14:48,540 +هو أكتر مفيد من هذا + +180 +00:14:55,150 --> 00:15:06,890 +حسنًا ، أعود إلى السؤال ، فهو + +181 +00:15:06,890 --> 00:15:16,770 +مثال آخر إذا كنت ترغب في رؤيته ، والقيم + +182 +00:15:16,770 --> 00:15:20,490 +الحاضرة لـ okay ، سنرى الأثارات الأخرى في + +183 +00:15:23,250 --> 00:15:34,090 +الان قيمة الدفع الداخلية IRR مايعنيه + +184 +00:15:34,090 --> 00:15:41,430 +IRR قيمة الدفع الداخلية IRR + +185 +00:15:41,430 --> 00:15:47,930 +IRR + +186 +00:15:47,930 --> 00:15:51,110 +هو عندما تتجه إلى الهجوم الأول + +187 +00:15:54,280 --> 00:15:59,820 +is equal the + +188 +00:15:59,820 --> 00:16:10,800 +cash inflow or the cash inflow in other words when + +189 +00:16:10,800 --> 00:16:14,680 +the cash flow the initial cash flow or the cash + +190 +00:16:14,680 --> 00:16:21,680 +out of flow is equal to the cash inflow okay I + +191 +00:16:21,680 --> 00:16:25,970 +will ask myselfعندما يكوين الـ Cash Outflow يكوين + +192 +00:16:25,970 --> 00:16:32,790 +Cash Inflow أو في كلمات أخرى، في مدرسة ما يكوين + +193 +00:16:32,790 --> 00:16:40,370 +Cash Inflow يكوين Cash Outflow من + +194 +00:16:40,370 --> 00:16:43,990 +المنصة + +195 +00:16:43,990 --> 00:16:49,590 +المثبتية، هذا Cash Inflow عندما يكوين Cash Outflow + +196 +00:16:50,780 --> 00:16:53,700 +Okay, so the cash .. this is the cash in the first + +197 +00:16:53,700 --> 00:17:00,300 +year one plus K raised to the power one then cash + +198 +00:17:00,300 --> 00:17:04,000 +flow for the second year one plus K raised to the + +199 +00:17:04,000 --> 00:17:09,600 +power two plus cash inflow for the n number of + +200 +00:17:09,600 --> 00:17:16,120 +years plus K I will ask myself at what rate .. so + +201 +00:17:16,120 --> 00:17:19,540 +when I'm asking at what rate I'm asking about at + +202 +00:17:19,540 --> 00:17:20,100 +what K + +203 +00:17:23,040 --> 00:17:28,560 +على مدرسة واحدة بمعرفة ان الـ cash inflows يكوين + +204 +00:17:28,560 --> 00:17:38,060 +مدرسة الـ initial cash flow لذلك سوف نحاول هذا في + +205 +00:17:38,060 --> 00:17:43,060 +هذه المدرسة تجعل مدرسة الـ initial cash flow يكوين + +206 +00:17:43,060 --> 00:17:46,480 +مدرسة الـ cash inflows لذلك قيمة الـ net present + +207 +00:17:46,480 --> 00:17:48,400 +value في هذه الحالة يكوين نصف + +208 +00:17:51,290 --> 00:17:55,610 +عندما انا اجهزة الانفلو المالية هي المالية + +209 +00:17:55,610 --> 00:17:59,830 +الخارجية المالية او الاستثمارات الأولى في هذه + +210 +00:17:59,830 --> 00:18:02,830 +الحالة قيمة الانترنت الموجودة هي 0 اذا قيمة + +211 +00:18:02,830 --> 00:18:06,790 +الانترنت موجودة عندما قيمة الانترنت موجودة هي + +212 +00:18:06,790 --> 00:18:12,050 +المالية المالية المالية خارجية المالية المالية + +213 +00:18:12,050 --> 00:18:13,190 +المالية الخارجية المالية المالية المالية الخارجية + +214 +00:18:13,190 --> 00:18:14,190 +المالية المالية المالية الخارجية المالية المالية + +215 +00:18:14,190 --> 00:18:14,330 +المالية المالية المالية المالية المالية المالية + +216 +00:18:14,330 --> 00:18:14,690 +المالية المالية المالية المالية المالية المالية + +217 +00:18:14,690 --> 00:18:14,770 +المالية المالية المالية المالية المالية المالية + +218 +00:18:14,770 --> 00:18:20,060 +المالية الماليةor in ten the rate of return so how + +219 +00:18:20,060 --> 00:18:25,260 +we answer this is a trial and error this is the + +220 +00:18:25,260 --> 00:18:31,480 +answer from the exam perspective because you may + +221 +00:18:31,480 --> 00:18:36,090 +waste your time in looking what is the bestIrr I + +222 +00:18:36,090 --> 00:18:40,510 +will try to make them groups your answer should be + +223 +00:18:40,510 --> 00:18:45,030 +between 15 and 20 for instance so you don't need + +224 +00:18:45,030 --> 00:18:49,510 +to look in 14 or to look in the 17 or in the in 25 + +225 +00:18:49,510 --> 00:18:55,670 +just focus your triangular between 15 and 20 try + +226 +00:18:55,670 --> 00:18:58,610 +to narrow down your focus if I'm wearing your + +227 +00:18:58,610 --> 00:19:04,690 +shoes I will try the first thing 1717 في الأوسط + +228 +00:19:04,690 --> 00:19:12,430 +إذا كانت قيمة الـ net present هو أكتر من 17 احاولي + +229 +00:19:12,430 --> 00:19:17,590 +شيء أكتر من 17 إذا كانت 17 تجعل نتيجة نتيجة نتيجة + +230 +00:19:17,590 --> 00:19:18,010 +نتيجة نتيجة نتيجة نتيجة نتيجة نتيجة نتيجة نتيجة + +231 +00:19:18,010 --> 00:19:20,090 +نتيجة نتيجة نتيجة نتيجة نتيجة نتيجة نتيجة نتيجة + +232 +00:19:20,090 --> 00:19:20,250 +نتيجة نتيجة نتيجة نتيجة نتيجة نتيجة نتيجة نتيجة + +233 +00:19:20,250 --> 00:19:20,490 +نتيجة نتيجة نتيجة نتيجة نتيجة نتيجة نتيجة نتيجة + +234 +00:19:20,490 --> 00:19:20,690 +نتيجة نتيجة نتيجة نتيجة نتيجة نتيجة نتيجة نتيجة + +235 +00:19:20,690 --> 00:19:28,050 +نتيجة نتيجة + +236 +00:19:36,910 --> 00:19:40,770 +لذلك، قيمة الدفع الداخلية للinvestment متشابهة + +237 +00:19:40,770 --> 00:19:45,510 +لـYield to Maturity من مجموعة مخصصة في القرن 9 + +238 +00:19:45,510 --> 00:19:50,150 +سنتحدث عن هذا في القرن 9 إذا كان لدينا وقت لكن + +239 +00:19:50,150 --> 00:19:52,470 +بالتأكيد لا يوجد لدينا وقت لذلك قيمة الـNet + +240 +00:19:52,470 --> 00:19:56,950 +Present Value قيمة الـNet Present Value هي قيمة + +241 +00:19:56,950 --> 00:20:03,290 +الانفلو الأولى باعتبار أنها تأخذ أقل أو أقل صين + +242 +00:20:06,090 --> 00:20:10,590 +وإضافة لهم قانون الـ Stream Cash Flow لكي في + +243 +00:20:10,590 --> 00:20:12,750 +النهاية يكون لديك إزالة أزالة أزالة أزالة أزالة + +244 +00:20:12,750 --> 00:20:15,230 +أزالة أزالة أزالة أزالة أزالة أزالة أزالة أزالة + +245 +00:20:15,230 --> 00:20:17,130 +أزالة أزالة أزالة أزالة أزالة أزالة أزالة أزالة + +246 +00:20:17,130 --> 00:20:18,050 +أزالة أزالة أزالة أزالة أزالة أزالة أزالة أزالة + +247 +00:20:18,050 --> 00:20:19,710 +أزالة أزالة أزالة أزالة أزالة أزالة أزالة أزالة + +248 +00:20:19,710 --> 00:20:23,050 +أزالة أزالة أزالة أزالة أزالة أزالة أزالة أزالة + +249 +00:20:23,050 --> 00:20:29,510 +أزالة أزالة أزالة أزالة أ + +250 +00:20:35,570 --> 00:20:43,290 +إذا IRR أقل من K، فننقل المشروع، وإذا IRR أقل من + +251 +00:20:43,290 --> 00:20:49,030 +K، فنحن على الجانب، يعني نحن مقفلين هنا، على + +252 +00:20:49,030 --> 00:20:55,470 +الجانب، نحن على الجانب، نقبل أو ننقل، فهو 50-50، + +253 +00:20:55,470 --> 00:20:59,210 +حسنًا؟ + +254 +00:20:59,210 --> 00:21:02,290 +عود + +255 +00:21:02,290 --> 00:21:03,430 +إلى المشروع Long + +256 +00:21:06,430 --> 00:21:12,400 +فى project longمن المتوقع أن يقدم خمس سنة من + +257 +00:21:12,400 --> 00:21:16,380 +المستخدمات المالية وأن يتطلب انهيار مستخدم 100 ألف + +258 +00:21:16,380 --> 00:21:18,280 +دولار المستخدم المستخدم المستخدم المستخدم المستخدم + +259 +00:21:18,280 --> 00:21:18,440 +المستخدم المستخدم المستخدم المستخدم المستخدم + +260 +00:21:18,440 --> 00:21:19,980 +المستخدم المستخدم المستخدم المستخدم المستخدم + +261 +00:21:19,980 --> 00:21:21,900 +المستخدم المستخدم المستخدم المستخدم المستخدم + +262 +00:21:21,900 --> 00:21:22,940 +المستخدم المستخدم المستخدم المستخدم المستخدم + +263 +00:21:22,940 --> 00:21:22,960 +المستخدم المستخدم المستخدم المستخدم المستخدم + +264 +00:21:22,960 --> 00:21:23,640 +المستخدم المستخدم المستخدم المستخدم المستخدم + +265 +00:21:23,640 --> 00:21:25,460 +المستخدم المستخدم المستخدم المستخدم المستخدم + +266 +00:21:25,460 --> 00:21:39,420 +المستخدم المستخدم المستخدم المستخدم المستخدم + +267 +00:21:40,880 --> 00:21:49,480 +بسبب أن الـ 17% يبدو كإشارة يمكنك تجربة أشياء أكتر + +268 +00:21:49,480 --> 00:21:59,540 +من 17 أو أقل من 17 و ترى إذا حاولت IRR أكتر من 17 + +269 +00:22:01,290 --> 00:22:07,030 +على سبيل المثال، تحاول الـ 18% و تجد أن الـ 18% + +270 +00:22:07,030 --> 00:22:10,750 +ينتج قيمة محفظة محفظة محفظة محفظة محفظة محفظة + +271 +00:22:10,750 --> 00:22:11,870 +محفظة محفظة محفظة محفظة محفظة محفظة محفظة محفظة + +272 +00:22:11,870 --> 00:22:13,450 +محفظة محفظة محفظة محفظة محفظة محفظة محفظة محفظة + +273 +00:22:13,450 --> 00:22:13,710 +محفظة محفظة محفظة محفظة محفظة محفظة محفظة محفظة + +274 +00:22:13,710 --> 00:22:17,310 +محفظة محفظة محفظة محفظة محفظة محفظة محفظة محفظة + +275 +00:22:17,310 --> 00:22:25,510 +محلذلك، هل تتذكر هذا الـ Cash Stream؟ 100,000$ هي + +276 +00:22:25,510 --> 00:22:29,770 +الانتجار الانيشاني والدفع المالي في السنة 170,000$ + +277 +00:22:29,770 --> 00:22:34,150 +وفي السنة 5 هو 10,000$، فماذا يمكنني فعله؟ + +278 +00:22:39,950 --> 00:22:46,090 +الأول هو تجربة شيء يمكنك تجربه بالـ 18% و ترى ما + +279 +00:22:46,090 --> 00:22:52,710 +هو النتيجة او تجرب 14% ثم ترى النتيجة حسنا، انظر + +280 +00:22:52,710 --> 00:22:56,670 +هنا نعم، + +281 +00:22:56,670 --> 00:23:02,890 +إنه مثل تجربة وخطأ حسنا، قبل أن نظهر طريقة الحلول + +282 +00:23:02,890 --> 00:23:08,590 +دعونا أولا ننظر إلى الحلول التي سنجد أنها 27% + +283 +00:23:11,400 --> 00:23:14,540 +دسكوتed project capital for one year through five + +284 +00:23:14,540 --> 00:23:19,440 +years which is 27% كيف نحصل على 27%؟ بمجرد تجربة + +285 +00:23:19,440 --> 00:23:31,120 +وخطأ هذا يستخدم بالإكسل في مجلسك ليس مثل هذا، إنه + +286 +00:23:31,120 --> 00:23:34,560 +مثل إعطاءك إشعارات عن كيفية إجابة هذه السؤال + +287 +00:23:38,220 --> 00:23:42,660 +لا تحتاج حتى لكي تحاول خطأ ، لا تحتاج حتى .. على + +288 +00:23:42,660 --> 00:23:51,260 +سبيل المثال، إذا قيمة الـ net present if K == 70 + +289 +00:23:51,260 --> 00:23:54,940 +% K + +290 +00:23:54,940 --> 00:23:58,640 +هو 70% ويعني نتيجة نتيجة نتيجة نتيجة نتيجة نتيجة + +291 +00:23:58,640 --> 00:24:00,820 +نتيجة نتيجة نتيجة نتيجة نتيجة نتيجة نتيجة نتيجة + +292 +00:24:00,820 --> 00:24:02,080 +نتيجة نتيجة نتيجة نتيجة نتيجة نتيجة نتيجة نتيجة + +293 +00:24:02,080 --> 00:24:02,340 +نتيجة نتيجة نتيجة نتيجة نتيجة نتيجة نتيجة نتيجة + +294 +00:24:02,340 --> 00:24:06,130 +نتيجة نتيجة نتيجة نتيجة نتيجgreater than 17 + +295 +00:24:06,130 --> 00:24:09,770 +percent yes definitely yes you don't need even to + +296 +00:24:09,770 --> 00:24:15,610 +do calculations okay is greater than so the + +297 +00:24:15,610 --> 00:24:20,530 +possibility of IRR the possibility of IRR one is + +298 +00:24:20,530 --> 00:24:28,690 +less than 17 percent is equal 17 percent is + +299 +00:24:28,690 --> 00:24:36,810 +greater than 17 percent no oneneither so very + +300 +00:24:36,810 --> 00:24:41,170 +simple just go to the greater than however some + +301 +00:24:41,170 --> 00:24:45,950 +students they they should think twice because they + +302 +00:24:45,950 --> 00:24:48,850 +don't understand what is exactly the IRR means + +303 +00:24:48,850 --> 00:24:51,990 +just in one second take it is greater than 70 + +304 +00:24:51,990 --> 00:24:56,970 +percent it doesn't need that much thinking on okay + +305 +00:24:56,970 --> 00:25:05,320 +yes again try train yourself now ifالقيم التجارية + +306 +00:25:05,320 --> 00:25:13,980 +الموجودة في البرنامج تقريبًا هي 0 وK + +307 +00:25:13,980 --> 00:25:22,320 +هي 17% ماذا يعني IRR؟ ماذا يعني IRR إذا؟ انظر إلى + +308 +00:25:22,320 --> 00:25:28,560 +ال .. لديك الـ less than 17% و equal 17% لديك الـ + +309 +00:25:28,560 --> 00:25:35,080 +equal لأن إذا استخدمت 17%القيمة الموجودة على + +310 +00:25:35,080 --> 00:25:42,420 +الانترنت هي 0 وهذه هي التقنية لـ IRR حسنا، لكن + +311 +00:25:42,420 --> 00:25:51,920 +المشكلة هي كما ذكرت في كل مرة المشكلة هي، على + +312 +00:25:51,920 --> 00:25:55,740 +الرغم من أن جمال المفاتيح لـ IRR لديه بعض + +313 +00:25:55,740 --> 00:26:03,220 +المقاومات المقاومات لـ IRR لديها أحيانًا أكتر + +314 +00:26:03,220 --> 00:26:09,760 +إجاباتعلى سبيل المثال، إذا كان لدينا نقاط خاطئة من + +315 +00:26:09,760 --> 00:26:16,560 +المدفع، فهو يتجنب أكتر من إحدى IRR إذا كان لدي + +316 +00:26:16,560 --> 00:26:18,420 +أكتر من إحدى IRR إذا كان لدي أكتر من إحدى IRR إذا + +317 +00:26:18,420 --> 00:26:18,440 +كان لدي أكتر من إحدى IRR إذا كان لدي أكتر من إحدى + +318 +00:26:18,440 --> 00:26:19,360 +IRR إذا كان لدي أكتر من إحدى IRR إذا كان لدي أكتر + +319 +00:26:19,360 --> 00:26:19,560 +لدي أكتر من إحدى IRR إذا كان لدي أكتر من إحدة IRR + +320 +00:26:19,560 --> 00:26:22,660 +إذا كان لدي أكتر من إحدة IRR إذا كان لدي أكتر من + +321 +00:26:22,660 --> 00:26:31,710 +إحدة IRR إذا كان لدي أكتر من إحدةإذا كان لدينا هذا + +322 +00:26:31,710 --> 00:26:36,430 +15000$ للمقالات الأولى وفي السنة الأولى لدينا + +323 +00:26:36,430 --> 00:26:40,630 +10000$ في السنة الثانية لدينا 20000$ في السنة + +324 +00:26:40,630 --> 00:26:48,770 +الثالثة لدينا أقل من 5000$ لدينا اتفاقات اولى + +325 +00:26:48,770 --> 00:26:52,950 +اتفاقات اولى اتفاقات اولى اتفاقات اولى اتفاقات + +326 +00:26:52,950 --> 00:26:53,630 +اولى اتفاقات اولى اتفاقات اولى اتفاقات اولى + +327 +00:26:53,630 --> 00:26:54,190 +اتفاقات اولى اتفاقات اولى اتفاقات اولى اتفاقات + +328 +00:26:54,190 --> 00:26:54,250 +اولى اتفاقات اولى اتفاقات اولى + +329 +00:27:02,660 --> 00:27:06,920 +Okay, so this is the weaknesses of IRR Okay, + +330 +00:27:07,160 --> 00:27:10,100 +because of these weaknesses, we cannot say hands + +331 +00:27:10,100 --> 00:27:14,040 +off and stop What is the solution? The solution by + +332 +00:27:14,040 --> 00:27:18,520 +MIRR Modified + +333 +00:27:18,520 --> 00:27:22,540 +Internal Rate of Return What it means modified + +334 +00:27:22,540 --> 00:27:28,920 +internal rate of return is to try to manipulateالـ + +335 +00:27:28,920 --> 00:27:33,360 +Cash Streams. على سبيل المثال، انظر إلى هذا المثال + +336 +00:27:33,360 --> 00:27:39,660 +هنا، ماذا نستطيع أن نفعل؟ ما هي الاختيار؟ أن نخلص + +337 +00:27:39,660 --> 00:27:52,860 +من اهتمام نمط الـ Cash Negative. فماذا تعتقد؟ نريد + +338 +00:27:52,860 --> 00:27:57,860 +أن نخلص من المعنى الـ Negative.بضيف خمسين where + +339 +00:27:57,860 --> 00:28:02,780 +fifty where to this okay + +340 +00:28:02,780 --> 00:28:06,400 +very simple انا بكون عندي اتنين و باخد مثال فاصل + +341 +00:28:06,400 --> 00:28:12,520 +لل IRR so try to make your mind up نفس ال line try + +342 +00:28:12,520 --> 00:28:17,260 +ازيد من الأول three ازيد من الأول من الدنيا by + +343 +00:28:17,260 --> 00:28:19,720 +five thousand بضيفها على الرمز الخمسة و خمسين you + +344 +00:28:19,720 --> 00:28:26,200 +are right but wrong it's how it comesانها نصف و + +345 +00:28:26,200 --> 00:28:31,340 +نصف انت محق بسبب كلمة أولى اللي قلت لك دعنا نضيف + +346 +00:28:31,340 --> 00:28:36,960 +المال من خلالها لأول استثمار استثمار الانيش نعم صح + +347 +00:28:36,960 --> 00:28:42,100 +ولكن هذا غير صح لانك لا تعتبر قيمة الوقت المالي + +348 +00:28:42,100 --> 00:28:47,900 +حسنًا، كيف يمكننا أن نخلص من هذا المشكلة؟ بسيطة + +349 +00:28:47,900 --> 00:28:53,870 +جدالا تطير في الأرض، فهي فقط هنا، وهو بسيط جدًا + +350 +00:28:53,870 --> 00:28:58,710 +هنا هذا المال خارج القانون يأتي في الكتارجير، لذلك + +351 +00:28:58,710 --> 00:29:06,210 +ماذا إذا انا اختيار هذا 1 plus K رزق القوة 3 وعودة + +352 +00:29:06,210 --> 00:29:10,870 +إلى 50 ألف دولار حسنًا، + +353 +00:29:10,870 --> 00:29:17,670 +لذلك ما فعلته هنا هو فقط اختيارالـ 5000 دولار بـ 1 + +354 +00:29:17,670 --> 00:29:21,610 +plus k ريز to the power 3 لأنه يأتي في الثالث عام + +355 +00:29:21,610 --> 00:29:26,470 +لذا في هنا نضيف الى 50,000 دولار لذا نعم أنت محق + +356 +00:29:26,470 --> 00:29:31,300 +لكن مرة أخرى لديك قليل من الخطأالخطأ الصغير هو + +357 +00:29:31,300 --> 00:29:35,520 +أننا نقوم بإدارة هذا بإدارة قيمة الوقت من المال ثم + +358 +00:29:35,520 --> 00:29:40,080 +بسيط جدا فقط اضيف الـ 5000 اشترك الـ 5000 في + +359 +00:29:40,080 --> 00:29:46,360 +الانتجار الأولى و بعدها اعود لإجابة ال IRR طبيعي + +360 +00:29:46,360 --> 00:29:50,700 +جدًا، حسنا؟ + +361 +00:29:50,700 --> 00:29:59,200 +لذلك هذا هو المشكلة التعامل مع ال IRR، فقط لحظة + +362 +00:30:01,580 --> 00:30:04,600 +مشكلة مع IRR ومشكلة بالدفع المستقبلية مع اتفاقات + +363 +00:30:04,600 --> 00:30:07,700 +مفارقة مع اتفاقات + +364 +00:30:07,700 --> 00:30:09,520 +مفارقة مع اتفاقات مفارقة مع اتفاقات مفارقة مع + +365 +00:30:09,520 --> 00:30:10,280 +اتفاقات مفارقة مع اتفاقات مفارقة مع اتفاقات مفارقة + +366 +00:30:10,280 --> 00:30:10,740 +مع اتفاقات مفارقة مع اتفاقات مفارقة مع اتفاقات + +367 +00:30:10,740 --> 00:30:12,060 +مفارقة مع اتفاقات مفارقة مع اتفاقات مفارقة مع + +368 +00:30:12,060 --> 00:30:15,460 +اتفاقات مفارقة مع اتفاقات مفارقة مع اتفاقات مفارقة + +369 +00:30:15,460 --> 00:30:22,580 +مع اتفاقات مفارقة مع اتفاقات مفارقة مع اتفاقات + +370 +00:30:22,580 --> 00:30:29,160 +مفارقة مع اتفاهي نقل أو نقل. Cash inflow تتبع + +371 +00:30:29,160 --> 00:30:34,180 +عملية إخراج الـ Cash كما في حالة دفعية نت present + +372 +00:30:34,180 --> 00:30:38,080 +value أكبر من 0 تشير إلى أن الـ IRR أقل من السعر + +373 +00:30:38,080 --> 00:30:42,760 +المستخدم لتحسين نت present value نت present value + +374 +00:30:42,760 --> 00:30:45,420 +يؤدي إلى الاختيار المناسب في كتابة الـ + +375 +00:30:45,420 --> 00:30:47,480 +conventional وكتابة الـ unconventional cash flow + +376 +00:30:47,480 --> 00:30:53,990 +لذلك مع إشارة نقل بخيربالتالي، هذا البرنامج يستخدم + +377 +00:30:53,990 --> 00:30:58,110 +قيمة Net Present while تجارب تجارب تجارب تجارب + +378 +00:30:58,110 --> 00:30:58,910 +تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب + +379 +00:30:58,910 --> 00:30:58,990 +تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب + +380 +00:30:58,990 --> 00:30:59,030 +تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب + +381 +00:30:59,030 --> 00:30:59,210 +تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب + +382 +00:30:59,210 --> 00:31:17,010 +تجارب تجارب تجارب تجارب تجارب تجارب تج + +383 +00:31:17,510 --> 00:31:21,090 +في هذه الحالة سيكون لدينا أكثر من واحد IRR نحن + +384 +00:31:21,090 --> 00:31:27,250 +لدينا IRR 10% ونحن لدينا IRR 20% لذلك ما يمكننا + +385 +00:31:27,250 --> 00:31:34,870 +فعله ما يمكننا فعله هو أن نجعل ال .. سنعود في + +386 +00:31:34,870 --> 00:31:37,890 +المجلد التالف عن هذا الموضوع لأننا لا نحب التحدث + +387 +00:31:37,890 --> 00:31:42,470 +عنه شكرا جزيلا وإن شاء الله نشوفكم يعني + diff --git a/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/2LnOF1vYj7Y_raw.json b/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/2LnOF1vYj7Y_raw.json new file mode 100644 index 0000000000000000000000000000000000000000..e49de27b32d64a80349aa8a1f75e87c9e9bb12d4 --- /dev/null +++ b/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/2LnOF1vYj7Y_raw.json @@ -0,0 +1 @@ +{"segments": [{"id": 1, "seek": 4742, "start": 20.82, "end": 47.42, "text": "احنا بسم الله الرحمن الرحيم في chapter four .. chapter four .. ال chapter السابق كح .. كنا نحكي عن ال cash flow 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Yes, very simple. Economic change, sorry? Economic change, so what they .. 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Yes? No? Okay, let's see this example here, example 5.1 Suppose that you deposited 500$ in your investments or in your saving account that earns 5% annual interest How much will you have in your account after two years using a simple interest?", "tokens": [8297, 11, 604, 1168, 30, 1079, 30, 883, 30, 1033, 11, 718, 311, 536, 341, 1365, 510, 11, 1365, 1025, 13, 16, 21360, 300, 291, 42002, 5923, 3, 294, 428, 13784, 420, 294, 428, 6816, 2696, 300, 46936, 1025, 4, 9784, 1179, 1012, 709, 486, 291, 362, 294, 428, 2696, 934, 732, 924, 1228, 257, 2199, 1179, 30], "avg_logprob": -0.2666843099109197, "compression_ratio": 1.4943181818181819, "no_speech_prob": 0.0, "words": [{"start": 1563.52, "end": 1563.88, "word": "Okay,", "probability": 0.501953125}, {"start": 1564.02, "end": 1564.14, "word": " any", "probability": 0.326171875}, {"start": 1564.14, "end": 1564.54, "word": " question?", "probability": 0.74951171875}, {"start": 1566.78, "end": 1567.58, "word": " Yes?", "probability": 0.58544921875}, {"start": 1567.78, "end": 1568.1, "word": " No?", "probability": 0.8134765625}, {"start": 1570.2, "end": 1571.0, "word": " Okay,", "probability": 0.62939453125}, {"start": 1571.34, "end": 1573.4, "word": " let's", "probability": 0.931884765625}, {"start": 1573.4, "end": 1573.6, "word": " see", "probability": 0.91650390625}, {"start": 1573.6, "end": 1573.96, "word": " this", "probability": 0.9375}, {"start": 1573.96, "end": 1574.34, "word": " example", "probability": 0.978515625}, {"start": 1574.34, "end": 1574.58, "word": " here,", "probability": 0.7998046875}, {"start": 1574.66, "end": 1574.94, "word": " example", "probability": 0.85546875}, {"start": 1574.94, "end": 1575.24, "word": " 5", "probability": 0.921875}, {"start": 1575.24, "end": 1575.7, "word": ".1", "probability": 0.98486328125}, {"start": 1575.7, "end": 1576.28, "word": " Suppose", "probability": 0.308837890625}, {"start": 1576.28, "end": 1576.58, "word": " that", "probability": 0.927734375}, {"start": 1576.58, "end": 1576.76, "word": " you", "probability": 0.98193359375}, {"start": 1576.76, "end": 1577.2, "word": " deposited", "probability": 0.9306640625}, {"start": 1577.2, "end": 1578.02, "word": " 500", "probability": 0.6083984375}, {"start": 1578.02, "end": 1578.46, "word": "$", "probability": 0.853515625}, {"start": 1578.46, "end": 1578.9, "word": " in", "probability": 0.9365234375}, {"start": 1578.9, "end": 1579.1, "word": " your", "probability": 0.89697265625}, {"start": 1579.1, "end": 1579.68, "word": " investments", "probability": 0.78125}, {"start": 1579.68, "end": 1580.08, "word": " or", "probability": 0.876953125}, {"start": 1580.08, "end": 1580.24, "word": " in", "probability": 0.85888671875}, {"start": 1580.24, "end": 1580.4, "word": " your", "probability": 0.8896484375}, {"start": 1580.4, "end": 1580.66, "word": " saving", "probability": 0.76025390625}, {"start": 1580.66, "end": 1581.1, "word": " account", "probability": 0.71142578125}, {"start": 1581.1, "end": 1581.94, "word": " that", "probability": 0.56591796875}, {"start": 1581.94, "end": 1582.48, "word": " earns", "probability": 0.68408203125}, {"start": 1582.48, "end": 1583.2, "word": " 5", "probability": 0.94482421875}, {"start": 1583.2, "end": 1583.64, "word": "%", "probability": 0.96044921875}, {"start": 1583.64, "end": 1584.1, "word": " annual", "probability": 0.9326171875}, {"start": 1584.1, "end": 1584.84, "word": " interest", "probability": 0.9296875}, {"start": 1584.84, "end": 1585.42, "word": " How", "probability": 0.5966796875}, {"start": 1585.42, "end": 1585.82, "word": " much", "probability": 0.9169921875}, {"start": 1585.82, "end": 1586.18, "word": " will", "probability": 0.86669921875}, {"start": 1586.18, "end": 1586.34, "word": " you", "probability": 0.97216796875}, {"start": 1586.34, "end": 1586.78, "word": " have", "probability": 0.9521484375}, {"start": 1586.78, "end": 1587.5, "word": " in", "probability": 0.95361328125}, {"start": 1587.5, "end": 1587.66, "word": " your", "probability": 0.88525390625}, {"start": 1587.66, "end": 1588.02, "word": " account", "probability": 0.92138671875}, {"start": 1588.02, "end": 1588.48, "word": " after", "probability": 0.83544921875}, {"start": 1588.48, "end": 1588.74, "word": " two", "probability": 0.5810546875}, {"start": 1588.74, "end": 1589.14, "word": " years", "probability": 0.9306640625}, {"start": 1589.14, "end": 1590.38, "word": " using", "probability": 0.59619140625}, {"start": 1590.38, "end": 1590.64, "word": " a", "probability": 0.97119140625}, {"start": 1590.64, "end": 1590.84, "word": " simple", "probability": 0.8134765625}, {"start": 1590.84, "end": 1591.28, "word": " interest?", "probability": 0.94287109375}], "temperature": 1.0}, {"id": 62, "seek": 161862, "start": 1591.9, "end": 1618.62, "text": "Okay, so let's use this time So, 500$ for two years, is it right? So, you will invest 500$ for two years Let's see, the sample interest and compound interest and the I is 5%", "tokens": [8297, 11, 370, 718, 311, 764, 341, 565, 407, 11, 5923, 3, 337, 732, 924, 11, 307, 309, 558, 30, 407, 11, 291, 486, 1963, 5923, 3, 337, 732, 924, 961, 311, 536, 11, 264, 6889, 1179, 293, 14154, 1179, 293, 264, 286, 307, 1025, 4], "avg_logprob": -0.35738033056259155, "compression_ratio": 1.3622047244094488, "no_speech_prob": 0.0, "words": [{"start": 1591.9, "end": 1592.72, "word": "Okay,", "probability": 0.228759765625}, {"start": 1593.46, "end": 1594.12, "word": " so", "probability": 0.31298828125}, {"start": 1594.12, "end": 1594.48, "word": " let's", "probability": 0.9326171875}, {"start": 1594.48, "end": 1594.88, "word": " use", "probability": 0.88134765625}, {"start": 1594.88, "end": 1595.26, "word": " this", "probability": 0.95703125}, {"start": 1595.26, "end": 1596.0, "word": " time", "probability": 0.77685546875}, {"start": 1596.0, "end": 1599.38, "word": " 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"text": "525x1.05 فماذا؟ 26.25 فماذا؟ 551.25 فماذا؟ 551.25 فماذا؟ 551.25 فماذا؟ 551.25 فماذا؟ 551.25 فماذا؟ 551.25 فماذا؟ 551.25 فماذا؟", "tokens": [20, 6074, 87, 16, 13, 13328, 6156, 2304, 45636, 995, 22807, 7551, 13, 6074, 6156, 2304, 45636, 995, 22807, 1025, 18682, 13, 6074, 6156, 2304, 45636, 995, 22807, 1025, 18682, 13, 6074, 6156, 2304, 45636, 995, 22807, 1025, 18682, 13, 6074, 6156, 2304, 45636, 995, 22807, 1025, 18682, 13, 6074, 6156, 2304, 45636, 995, 22807, 1025, 18682, 13, 6074, 6156, 2304, 45636, 995, 22807, 1025, 18682, 13, 6074, 6156, 2304, 45636, 995, 22807, 1025, 18682, 13, 6074, 6156, 2304, 45636, 995, 22807], "avg_logprob": -0.33979669392827044, "compression_ratio": 4.390243902439025, "no_speech_prob": 0.0, "words": [{"start": 1771.5599999999997, "end": 1772.9599999999998, "word": "525x1", "probability": 0.4151611328125}, {"start": 1772.9599999999998, "end": 1774.36, "word": ".05", "probability": 0.951904296875}, {"start": 1774.36, "end": 1777.4, "word": " فماذا؟", 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{"start": 1375.03, "end": 1375.19, "word": " the", "probability": 0.91650390625}, {"start": 1375.19, "end": 1375.61, "word": " payments", "probability": 0.3779296875}, {"start": 1375.61, "end": 1377.37, "word": " we", "probability": 0.50732421875}, {"start": 1377.37, "end": 1377.51, "word": " don't", "probability": 0.979248046875}, {"start": 1377.51, "end": 1377.65, "word": " know", "probability": 0.9013671875}, {"start": 1377.65, "end": 1377.79, "word": " the", "probability": 0.9140625}, {"start": 1377.79, "end": 1378.21, "word": " payments", "probability": 0.86865234375}, {"start": 1378.21, "end": 1379.61, "word": " so", "probability": 0.6923828125}, {"start": 1379.61, "end": 1380.07, "word": " just", "probability": 0.92236328125}, {"start": 1380.07, "end": 1380.27, "word": " to", "probability": 0.95947265625}, {"start": 1380.27, "end": 1380.65, "word": " formulate", "probability": 0.9150390625}, {"start": 1380.65, "end": 1381.13, "word": " things", "probability": 0.8623046875}, 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divided by I. Be careful here. Before answering this question, be careful. This is the payment, okay?", "tokens": [2407, 1951, 264, 26179, 321, 362, 472, 3175, 472, 6666, 472, 1804, 286, 6005, 281, 264, 1347, 426, 6666, 538, 286, 13, 879, 5026, 510, 13, 4546, 13430, 341, 1168, 11, 312, 5026, 13, 639, 307, 264, 10224, 11, 1392, 30], "avg_logprob": -0.37127975693770815, "compression_ratio": 1.3357142857142856, "no_speech_prob": 0.0, "words": [{"start": 1388.64, "end": 1388.82, "word": "و", "probability": 0.2509765625}, {"start": 1388.82, "end": 1388.96, "word": " within", "probability": 0.04754638671875}, {"start": 1388.96, "end": 1389.16, "word": " the", "probability": 0.78173828125}, {"start": 1389.16, "end": 1389.52, "word": " brackets", "probability": 0.96630859375}, {"start": 1389.52, "end": 1389.78, "word": " we", "probability": 0.63720703125}, {"start": 1389.78, "end": 1390.14, "word": " have", "probability": 0.96875}, {"start": 1390.14, "end": 1391.04, "word": " one", "probability": 0.43408203125}, {"start": 1391.04, "end": 1391.8, "word": " minus", 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0.7171630859375}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 1807.743125, "duration_after_vad": 1659.417499999997} \ No newline at end of file diff --git a/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/BPd1_JMnA9E_postprocess.srt b/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/BPd1_JMnA9E_postprocess.srt new file mode 100644 index 0000000000000000000000000000000000000000..afd87d30ee732ed40c9df003c30a1bb2692261bf --- /dev/null +++ b/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/BPd1_JMnA9E_postprocess.srt @@ -0,0 +1,1672 @@ +1 +00:00:20,430 --> 00:00:23,730 +ال .. المرة الفاتة كنا نحكي عن موضوع ال .. ال + +2 +00:00:23,730 --> 00:00:27,930 +ethics in finance و هذا كتير مهم .. this is a very + +3 +00:00:27,930 --> 00:00:30,750 +important subject in finance some people they + +4 +00:00:30,750 --> 00:00:34,690 +underestimate the importance of ethics the ethical + +5 +00:00:34,690 --> 00:00:38,070 +things or the ethical behavior of managers may + +6 +00:00:38,070 --> 00:00:41,150 +lead the business to the bankruptcy ممكن يودي + +7 +00:00:41,150 --> 00:00:45,280 +الشركات لل .. لل .. للإفلاسيعني مثلا لو جينا حكينا + +8 +00:00:45,280 --> 00:00:48,740 +أنه في new projects or new installments and you + +9 +00:00:48,740 --> 00:00:52,680 +asking your brother to run this okay because your + +10 +00:00:52,680 --> 00:00:57,040 +brother is a contractor this is unethics so try to + +11 +00:00:57,040 --> 00:01:03,120 +consider many examples in the ethicsوما يدفع إلى + +12 +00:01:03,120 --> 00:01:10,440 +تأثير الإبداع على السوق والسوق + +13 +00:01:10,440 --> 00:01:17,580 +مليئة بالقصص بالإبداع من المديرين دعوني أعطيكم + +14 +00:01:17,580 --> 00:01:23,280 +مثال آخر، على سبيل المثال، شركة تقرر تطوير نوع + +15 +00:01:23,280 --> 00:01:29,730 +جديدو لا أحد يعرف، فقط مجلد الوزيرات يعرف أن + +16 +00:01:29,730 --> 00:01:33,790 +الشركة قرر تطوير نوع جديد من أجهزتها واحد من مجلد + +17 +00:01:33,790 --> 00:01:39,330 +الوزيرات اتصل به أو أقربه، تسمع، هناك أخبار أن + +18 +00:01:39,330 --> 00:01:42,330 +الشركة تريد تطوير نوع جديد من الأجهزة، تحاول أن + +19 +00:01:42,330 --> 00:01:48,330 +تشتر الأموال، فما يعني هذا؟ يعني أن المعلومات تم + +20 +00:01:48,330 --> 00:01:52,210 +إطلاقها للناس الذين لا يسمحوا بالعرف عن هذه + +21 +00:01:52,210 --> 00:01:57,450 +المعلوماتهذه غير صحيحة احاول أن تفكر في العديد من + +22 +00:01:57,450 --> 00:02:03,290 +الأشياء غير صحيحة من الوظيفة ومن + +23 +00:02:03,290 --> 00:02:07,630 +الموظفين عن هذا الموضوع مجرد مثال أخر أتذكر بين + +24 +00:02:07,630 --> 00:02:15,210 +شركات سيارة أنا لا أعرف إذا BMW وNissan أعتقد أنني + +25 +00:02:15,210 --> 00:02:20,090 +نسيت على أي حال واحد من الوظيفة أطلق تصميم الجهاز + +26 +00:02:21,830 --> 00:02:26,190 +of .. of the car to the competitors يعني راح أخد + +27 +00:02:26,190 --> 00:02:29,530 +التصميمات تبع ال motor و تبع السيارة و وداها ل ال + +28 +00:02:29,530 --> 00:02:33,810 +competitors this is ethics or unethics؟ this is + +29 +00:02:33,810 --> 00:02:38,070 +unethics مثلا if you are working in the company + +30 +00:02:38,070 --> 00:02:41,650 +and you know the customers and when you go home + +31 +00:02:41,650 --> 00:02:45,110 +لما ترجعوا ع البيت in the lunch time with your mom + +32 +00:02:45,110 --> 00:02:48,170 +and dad talking about your customersit is + +33 +00:02:48,170 --> 00:02:52,130 +unethics، مظبوط ولا لأ؟ هذا اللي بيصير، يعني في + +34 +00:02:52,130 --> 00:02:56,370 +وقت الأكل، أقول أه والله فلان إيجاه وفلان إيجات + +35 +00:02:56,370 --> 00:02:59,010 +وفلان إيجات وفلان إيجات وفلان إيجات وفلان إيجات + +36 +00:02:59,010 --> 00:02:59,330 +وفلان إيجات وفلان إيجات وفلان إيجات وفلان إيجات + +37 +00:02:59,330 --> 00:03:02,130 +وفلان إيجات وفلان إيجات وفلان إيجات وفلان إيجات + +38 +00:03:02,130 --> 00:03:05,710 +وفلان إيجات وفلان إيجات وفلان إيجات وفلان إيجات + +39 +00:03:05,710 --> 00:03:09,820 +وفلان إيجات وفلانin their use or in their interest + +40 +00:03:09,820 --> 00:03:13,540 +يعني مثلا الشركة اللي أخدت التصميمات راحت صممت + +41 +00:03:13,540 --> 00:03:17,820 +بذكر الماخ اللي هي سيارة الماخ اللي بتاعة ال اظن + +42 +00:03:17,820 --> 00:03:24,440 +تويوتا ميزوبيشي سيارة ميزوبيشي الماخ الماخ 3 الماخ + +43 +00:03:24,440 --> 00:03:29,620 +3 looks like BMWفال design تبعها similar to BMW، + +44 +00:03:29,620 --> 00:03:33,580 +بالظبط زي BMW، طب شو اللي صار؟ واحد من المدرأ سر + +45 +00:03:33,580 --> 00:03:36,240 +بال design وداله لشركة أخرى، الشركة الأخرى راحت + +46 +00:03:36,240 --> 00:03:39,620 +صنعت السيارة و طبعا BMW بتطلع و راجوا سيارتهم تمشي + +47 +00:03:39,620 --> 00:03:44,240 +في الشارعفي الحالة هذه مبيعات متسوبيشي راحت AS go + +48 +00:03:44,240 --> 00:03:47,740 +down صار في متسوبيشي .. this is unethical behavior + +49 +00:03:47,740 --> 00:03:53,240 +from the .. from the managers ف you should + +50 +00:03:53,240 --> 00:03:56,600 +consider this because of ethics .. ethical things + +51 +00:03:56,600 --> 00:04:05,340 +in 2002 the federal committee issue act known as + +52 +00:04:05,340 --> 00:04:12,880 +Sarbanes-Oxley Actسوف نتكلم عن سيربينز فقط تذكر + +53 +00:04:12,880 --> 00:04:21,420 +هذا هذا + +54 +00:04:21,420 --> 00:04:30,160 +معروف ك S O X سيربينز اوكسلي اكت ماهو هذا؟ بسبب + +55 +00:04:30,160 --> 00:04:36,840 +مشكلة الشركة بشكل عام الشركات + +56 +00:04:39,670 --> 00:04:43,270 +electing the board of directors okay and then the + +57 +00:04:43,270 --> 00:04:47,110 +board of directors hiring the managers managers + +58 +00:04:47,110 --> 00:04:52,330 +known as agents so managers known as agents + +59 +00:04:52,330 --> 00:04:56,870 +considered + +60 +00:04:56,870 --> 00:05:01,870 +as agents now managers what is the role of manager + +61 +00:05:01,870 --> 00:05:11,290 +is to achieve the interest of the ownersمديرين + +62 +00:05:11,290 --> 00:05:17,030 +يحصلوا على مهتمة المستخدمين، وهذا يعني أنهم يعملوا + +63 +00:05:17,030 --> 00:05:23,650 +على محافظة المستخدمين، والمديرين لديها مهتمتها لو + +64 +00:05:23,650 --> 00:05:31,410 +كانوا المديرين يركزوا فقط على مهتمتهم ولا يهتموا + +65 +00:05:31,410 --> 00:05:38,370 +بمهتمة المستخدم، فهذا ليس إيثيكسأو هذا يسبب في + +66 +00:05:38,370 --> 00:05:45,530 +مشكلة الشركات. لذلك، كيف تأكد الشركات أن المديرين + +67 +00:05:45,530 --> 00:05:49,310 +يحصلوا على مهارة المستخدم؟ هذا هو السؤال الكبير. + +68 +00:05:49,750 --> 00:05:56,410 +هذا هو السبب لما يأتي SOX لتأكد أن المديرين يحصلوا + +69 +00:05:56,410 --> 00:06:03,510 +على مهارة المستخدم أو مهمة الشركةلأن في الماضي إذا + +70 +00:06:03,510 --> 00:06:07,730 +كانت الرئيس لديه مشروع .. دعوني أقول عن هذا المثال + +71 +00:06:07,730 --> 00:06:11,910 +هنا إذا كان لديهم مشروع و كانوا يعتقدون أن هذا + +72 +00:06:11,910 --> 00:06:17,250 +المشروع سيساعدهم، فسيقررون أن يبدأوا على هذا + +73 +00:06:17,250 --> 00:06:22,190 +المشروع إذا كانوا يعتقدون أن هذا المشروع قد ينتهي + +74 +00:06:22,190 --> 00:06:27,530 +في إخراجهم، فلربما لا يقوموا باختيار هذه القرارةSo + +75 +00:06:27,530 --> 00:06:31,950 +in other words they evaluate the interest more + +76 +00:06:31,950 --> 00:06:33,130 +than the interest of the owners + +77 +00:06:36,580 --> 00:06:40,600 +هذا هو المشكلة الوظيفة الوظيفة الوظيفة موجودة + +78 +00:06:40,600 --> 00:06:44,320 +عندما أحد أو أكتر شخص يعرف كالعامل العامل هو الحمد + +79 +00:06:44,320 --> 00:06:48,860 +لله يتعامل مع أحد أو أكتر شخص لتخطيط على محافظته + +80 +00:06:48,860 --> 00:06:53,920 +أكتر شخص، مديرين في شركة، المديرين هم الوظيفين كما + +81 +00:06:53,920 --> 00:06:59,920 +أشرح هنا والمحافظين هم العاملين الآن مشكلة الوظيفة + +82 +00:06:59,920 --> 00:07:04,960 +حدثت عندما كان هناك اتفاق بين المحافظين والمديرين + +83 +00:07:05,550 --> 00:07:10,570 +بتكون في conflict between them okay such problems + +84 +00:07:10,570 --> 00:07:13,490 +are likely to arise more when the managers have + +85 +00:07:13,490 --> 00:07:16,010 +little or no ownership on the fair the problem + +86 +00:07:16,010 --> 00:07:18,390 +when the managers are not the owner of the + +87 +00:07:18,390 --> 00:07:21,350 +business لأن ممكن يكون ال manager مالهوش علاقة في + +88 +00:07:21,350 --> 00:07:26,210 +.. مش .. مش owner so they .. they are working on + +89 +00:07:26,210 --> 00:07:32,010 +their interestمثلًا هذا المثال لا تقوم بتحقيق + +90 +00:07:32,010 --> 00:07:35,710 +مشروع خطر لخوف أن تخسر عملات تخسر عملات تخسر عملات + +91 +00:07:35,710 --> 00:07:37,270 +تخسر عملات تخسر عملات تخسر عملات تخسر عملات تخسر + +92 +00:07:37,270 --> 00:07:39,350 +عملات تخسر عملات تخسر عملات تخسر عملات تخسر عملات + +93 +00:07:39,350 --> 00:07:41,390 +تخسر عملات تخسر عملات تخسر عملات تخسر عملات تخسر + +94 +00:07:41,390 --> 00:07:44,470 +عملات تخسر عملات تخسر عملات تخسر عملات تخسر عملات + +95 +00:07:44,470 --> 00:07:50,630 +تخسر عملات تخسر عملات تخسر + +96 +00:07:50,630 --> 00:07:54,730 +عملات تخسر + +97 +00:07:54,730 --> 00:07:59,970 +عWhat it means agents problem again people + +98 +00:07:59,970 --> 00:08:02,350 +evaluate their interests or managers evaluate + +99 +00:08:02,350 --> 00:08:06,430 +their interests more than the owners So what is + +100 +00:08:06,430 --> 00:08:10,790 +the solution؟ شو الحل؟ إنه إحنا ال managers في + +101 +00:08:10,790 --> 00:08:13,550 +عندهم interest و ال owners they have their own + +102 +00:08:13,550 --> 00:08:17,170 +interest is the solution to ignore the interest of + +103 +00:08:17,170 --> 00:08:21,070 +managers؟ No، so what is the solution هنا؟ + +104 +00:08:30,000 --> 00:08:35,020 +مستوى النجاح نعم + +105 +00:08:35,020 --> 00:08:43,580 +انت محق احد المفاوضات كما قالت هي مرتبط مستوى + +106 +00:08:43,580 --> 00:08:46,820 +الانسانتيف او مستوى الانسانتيف او مستوى الانسانتيف + +107 +00:08:46,820 --> 00:08:47,900 +او مستوى الانسانتيف او مستوى الانسانتيف او مستوى + +108 +00:08:47,900 --> 00:08:49,480 +الانسانتيف او مستوى الانسانتيف او مستوى الانسانتيف + +109 +00:08:49,480 --> 00:08:54,560 +او مستوى الانسانتيف + +110 +00:08:56,710 --> 00:09:00,490 +for instance to the extent you achieve the + +111 +00:09:00,490 --> 00:09:05,770 +business strategy you will get more incentives so + +112 +00:09:05,770 --> 00:09:08,970 +in this in the same time we consider the business + +113 +00:09:08,970 --> 00:09:12,170 +strategy and we consider the personal interest of + +114 +00:09:12,170 --> 00:09:19,550 +managers يعني هان فيها يعني انه احنا حققنا + +115 +00:09:19,550 --> 00:09:22,370 +الاستراتيجية تبع المنشأة و في نفس اللحظة ان المدرة + +116 +00:09:22,370 --> 00:09:27,240 +اعطانا حقوقهمbecause at the end of the day + +117 +00:09:27,240 --> 00:09:31,020 +managers are human beings المدرسة هم أشخاص ناس + +118 +00:09:31,020 --> 00:09:36,680 +humans و ال humans لهم حقوقهم so in this way we + +119 +00:09:36,680 --> 00:09:41,640 +can sort out this problem another thing we can + +120 +00:09:41,640 --> 00:09:48,180 +sort this out مين ممكن يقترحت؟ managers should + +121 +00:09:48,180 --> 00:09:52,720 +make their objectives with the firm objectives + +122 +00:09:55,570 --> 00:10:00,770 +yes you are right so it means business as you said + +123 +00:10:00,770 --> 00:10:06,830 +consider the objectives of managers and the + +124 +00:10:06,830 --> 00:10:09,410 +business itself should help managers to achieve + +125 +00:10:09,410 --> 00:10:12,970 +their objectives as well يعني كمان الشركة نفسها + +126 +00:10:12,970 --> 00:10:16,920 +بتساعد المدرسة أن هم يحققوا أهدافهمnot ignoring + +127 +00:10:16,920 --> 00:10:21,280 +them يعني زي ما انا بحقق أهدافك managers working + +128 +00:10:21,280 --> 00:10:25,380 +hard to achieve the business objectives برضه ال + +129 +00:10:25,380 --> 00:10:28,600 +business should consider the managers objective + +130 +00:10:28,600 --> 00:10:36,620 +okay هذا برضه حل آخر okay anything else okay by + +131 +00:10:36,620 --> 00:10:39,160 +monitoring ممكن احنا نعمل monitoring to the + +132 +00:10:39,160 --> 00:10:44,400 +managersإنراقب ال managers by the board of + +133 +00:10:44,400 --> 00:10:48,400 +directors and ensure managers achieve the business + +134 +00:10:48,400 --> 00:10:54,240 +interest we can give + +135 +00:10:54,240 --> 00:10:58,440 +them ownership ممكن نعطيهم honors يعني نعطيهم + +136 +00:10:58,440 --> 00:11:08,200 +bonuses so as you see here monitoring + +137 +00:11:10,630 --> 00:11:13,890 +كتابة مقالات، مقابلة، مقابلين، جميع هذه الأشياء + +138 +00:11:13,890 --> 00:11:21,310 +تحفظ و تأكد من أن قرار القرارين يصلحوا بأهداف + +139 +00:11:21,310 --> 00:11:25,550 +المعظمين يعني أي مشروع، نحفظه و نرى ماهي هذه + +140 +00:11:25,550 --> 00:11:31,900 +المشروعتحسن قيمة الشركة أو لا تحسن قيمة الشركة أو + +141 +00:11:31,900 --> 00:11:39,480 +لا تحسن قيمة الشركة أو لا تحسن قيمة + +142 +00:11:39,480 --> 00:11:52,220 +الشركة أو لا تحسن قيمة الشركة أو لا تحسن قيمة + +143 +00:11:52,220 --> 00:11:55,360 +الشركة أو لا تحسن قيمة الشركة أو لا تحسن قيمة + +144 +00:11:55,360 --> 00:11:55,840 +الشركة أو لا تحسن قيمة الشركة أو لا تحسن قيمة + +145 +00:11:55,840 --> 00:11:56,820 +الشركة أو لا تحسن قيمة الشركة أو لا تحسن قيمة + +146 +00:11:56,820 --> 00:11:57,400 +الشركة أو لا تحسن قيمة الشركة أو لا تحسن قيمة + +147 +00:11:57,400 --> 00:11:59,330 +الشركة أو لا تحسن قيمة الشهؤلاء الرقمين الرقمين + +148 +00:11:59,330 --> 00:12:06,610 +الرقمين الرقمين الرقمين الرقمين الرقمين الرقمين + +149 +00:12:06,610 --> 00:12:07,730 +الرقمين الرقمين الرقمين الرقمين الرقمين الرقمين + +150 +00:12:07,730 --> 00:12:08,790 +الرقمين الرقمين الرقمين الرقمين الرقمين الرقمين + +151 +00:12:08,790 --> 00:12:11,850 +الرقمين الرقمين الرقمين الرقمين الرقمين الرقمين + +152 +00:12:11,850 --> 00:12:11,870 +الرقمين الرقمين الرقمين الرقمين الرقمين الرقمين + +153 +00:12:11,870 --> 00:12:12,250 +الرقمين الرقمين الرقمين الرقمين الرقمين الرقمين + +154 +00:12:12,250 --> 00:12:26,770 +الرقمين الرقمين الرقمين الرقمين الرقمين + +155 +00:12:27,710 --> 00:12:30,750 +it means the dollar today is not equal to the + +156 +00:12:30,750 --> 00:12:39,030 +dollar tomorrow okay take this example here بدنا + +157 +00:12:39,030 --> 00:12:52,230 +المحاية so + +158 +00:12:52,230 --> 00:13:00,240 +the value of moneyإذا كان لديك 100 دولار اليوم، هل + +159 +00:13:00,240 --> 00:13:13,800 +100 دولار اليوم يقل 100 دولار بعد 1 عام؟ لأ لأ لأ + +160 +00:13:13,800 --> 00:13:16,500 +لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ + +161 +00:13:16,500 --> 00:13:16,600 +لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ + +162 +00:13:16,600 --> 00:13:16,640 +لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ + +163 +00:13:16,640 --> 00:13:16,660 +لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ + +164 +00:13:16,660 --> 00:13:24,210 +لأ لأ لأ لأ لأ لأ لأ لبتتناخص why it's keep + +165 +00:13:24,210 --> 00:13:28,070 +diminishing because of the inflation because of + +166 +00:13:28,070 --> 00:13:31,310 +the inflation the higher the inflation rate the + +167 +00:13:31,310 --> 00:13:35,630 +higher the diminishing value so this is why the + +168 +00:13:35,630 --> 00:13:43,830 +100$ today is not equal it could be equal 95$ ممكن + +169 +00:13:43,830 --> 00:13:51,530 +تساوي 95$بالنسبة للمستخدم، إذا أردنا أن نستخدم 100 + +170 +00:13:51,530 --> 00:13:57,830 +دولار، فإن قيمة المستخدم أو إعادة 100 دولار يجب أن + +171 +00:13:57,830 --> 00:14:04,790 +تتجاوز 100 دولار بعد 100 دولار. يمكن أن يكون 106 + +172 +00:14:04,790 --> 00:14:09,250 +دولار. ففي هذه الحالة، كم هو مستخدمنا؟ + +173 +00:14:12,150 --> 00:14:16,050 +معموماتنا كم؟ إذا كان لدينا 100 دولار اليوم + +174 +00:14:16,050 --> 00:14:23,090 +ودفعناه لسنة و بعد سنة نحصل على 106 ماهي الحصة + +175 +00:14:23,090 --> 00:14:31,110 +الحقيقية؟ لدينا 2 إجابات لدينا 6 و لدينا 11 ماذا + +176 +00:14:31,110 --> 00:14:38,370 +يعني 11؟ كم شخص يقول 11؟ فقط ارفع يديك فقط 2 كم + +177 +00:14:38,370 --> 00:14:39,850 +شخص يقول 6؟ + +178 +00:14:44,060 --> 00:14:51,020 +يعني في معايا 100 دولار استثمرتهم لعند السنة + +179 +00:14:51,020 --> 00:14:54,840 +الجاية جابولي 106 دولار في شغلة مهمة ان ال + +180 +00:14:54,840 --> 00:14:59,520 +inflation value خمسة دولار تنسوش ان قيمة ال 100 + +181 +00:14:59,520 --> 00:15:06,300 +دولار صارت 95 دولار في المستقبل يعني انخفضت قيمة + +182 +00:15:06,300 --> 00:15:07,500 +العملة بتاعتنا + +183 +00:15:10,760 --> 00:15:22,780 +Try to think أرباحنا 11%؟ 11% طيب إذا كان إحنا إذا + +184 +00:15:22,780 --> 00:15:27,840 +كان إحنا عندنا كام ال inflation rate ال inflation + +185 +00:15:27,840 --> 00:15:37,050 +rate كده؟ 5% طيب ال 100 دولارإذا احنا لازم تكون + +186 +00:15:37,050 --> 00:15:45,530 +مية و خمسة اذا جداش + +187 +00:15:45,530 --> 00:15:51,110 +الربح الفعلي دولار واحد احنا ربحنا بس دولار + +188 +00:15:51,110 --> 00:15:54,350 +ماربحنا ستة ولا ربحنا احداشر دولار just one dollar + +189 +00:15:54,350 --> 00:15:58,550 +ليش؟ خليني بالمنطقة ال 100 دولار اللي استثمرت فيه + +190 +00:15:58,550 --> 00:16:04,120 +اللي كانت معايا بجيبتي جداش بتجيب بعد سنة؟هى نفسها + +191 +00:16:04,120 --> 00:16:08,740 +تساوى 105 دولار طبعا هى نفسها بتجيب ال 105 دولار + +192 +00:16:08,740 --> 00:16:11,660 +يعني احنا بال 100 دولار مثلا نشري كيسة طحين + +193 +00:16:11,660 --> 00:16:17,180 +بالعربي بقت سنة الطحين رتفع بصينا ندفع 105 دولار + +194 +00:16:17,180 --> 00:16:21,460 +ال 100 دولارها بيساوى 105 دولار طبيعى طبعا اذا ال + +195 +00:16:21,460 --> 00:16:24,320 +investment value هى what is the exceed of the + +196 +00:16:24,320 --> 00:16:27,480 +inflation rate هى اللى بتزيد عن ال inflation rate + +197 +00:16:27,480 --> 00:16:30,220 +اذا احنا ال principle تبعتنا اللى بدأنا فيها 100 + +198 +00:16:30,220 --> 00:16:35,150 +لكن في عندى انا 105مية و خمسة دولار لنفترض ان هنا + +199 +00:16:35,150 --> 00:16:38,250 +ال sugar is equal one hundred dollar و ال sugar + +200 +00:16:38,250 --> 00:16:41,690 +صار برضه مية و مية .. طب قداش انا اربحت؟ في المية + +201 +00:16:41,690 --> 00:16:44,250 +و ستة اذا انا اربحت مية و ستة اذا just one dollar + +202 +00:16:44,250 --> 00:16:49,230 +the profits هذا the .. the importance of inflation + +203 +00:16:49,230 --> 00:16:53,310 +rate اه تفكر السنة الخمسة و تسعين؟ شو ال خمسة و + +204 +00:16:53,310 --> 00:16:58,070 +تسعين؟ بقى مية و خمسة اه في الحالة هذه ان المية و + +205 +00:16:58,070 --> 00:17:00,250 +الدولار انقلت قيمتها يعني المية و الدولار اتضلت في + +206 +00:17:00,250 --> 00:17:06,040 +جيبتي قيمتها الفعلية 95التلات ديانير .. التلات + +207 +00:17:06,040 --> 00:17:12,140 +ديانير .. ال three .. التلات ديانير قبل اربعين سنة + +208 +00:17:12,140 --> 00:17:16,920 +كنا نشتري فيهم دلمان في الذاتون اليوم التلات + +209 +00:17:16,920 --> 00:17:22,600 +ديانير ولا إشي لكن جداش قيمتهم قيمتهم الحقيقية + +210 +00:17:22,600 --> 00:17:27,900 +الآن nothing ولا إشي يعني قيمتهم الحقيقية زي ما + +211 +00:17:27,900 --> 00:17:33,240 +قلنا ال 100 دولار بتضلها تنزل هناالـ 100 دولار في + +212 +00:17:33,240 --> 00:17:38,580 +الحالة تبعتنا 95 إذا ضلنا نمشي مع الزمن مع ال time + +213 +00:17:38,580 --> 00:17:42,060 +هتظلها ال 100 دولار ممكن تساوي 5 دولارات قيمة + +214 +00:17:42,060 --> 00:17:48,420 +فعلية مثلا بعد 30 سنة زي ما التلات دالينير كانت + +215 +00:17:48,420 --> 00:17:53,360 +ثمنهم دلمين أرض في الزتون بعدين في معمرور الزمن + +216 +00:17:53,360 --> 00:17:58,920 +مشيت مشيت التلات دالينير عايشت فكتير cases بتمر + +217 +00:17:58,920 --> 00:18:04,510 +علينا بالقصص هذهوبالتالي هان the time value of + +218 +00:18:04,510 --> 00:18:07,190 +money ليش؟ إذا to protect the money from + +219 +00:18:07,190 --> 00:18:10,410 +diminishing we have to invest عشان هيك ربنا سبحانه + +220 +00:18:10,410 --> 00:18:13,670 +وتعالى بيقول والذين يكنزون الذهب أو الفضة ولا + +221 +00:18:13,670 --> 00:18:17,050 +يفقونها في سبيل الله يوم يحمي عليها في نار جهنم + +222 +00:18:17,050 --> 00:18:20,570 +فتكوا بها جباههم وجنوبهم وظهورهم هذا ما كنزتم + +223 +00:18:20,570 --> 00:18:24,300 +لأنفسكم فذوقوا ما كنتم تكنزونفي سبيل الله ايش + +224 +00:18:24,300 --> 00:18:28,460 +بيقولوا العلماء بيقولوا انه لما انسان يفتح مصنع + +225 +00:18:28,460 --> 00:18:32,180 +اكم واحد بيشغل في المصنع هذا في سبيل الله شوفت اكم + +226 +00:18:32,180 --> 00:18:35,120 +واحد احنا شغلنا في المصنع لما هدول we keep the + +227 +00:18:35,120 --> 00:18:39,140 +gold بس for saving انه احنا بس بنخزله معناه الكلام + +228 +00:18:39,140 --> 00:18:42,420 +انه احنا في ناس اخرين المفروض احنا نشغلهم وما + +229 +00:18:42,420 --> 00:18:49,480 +شغلنا همش فهمتوا كيف؟ وبالتالي هم ال saving to + +230 +00:18:49,480 --> 00:18:55,320 +invest to protectthe money from diminishing إحنا + +231 +00:18:55,320 --> 00:18:59,240 +بنحمل أموال من الخفاض، يعني لو حاجة بتاعة زمان + +232 +00:18:59,240 --> 00:19:02,960 +هوشت لها مئة دولار أو عشرين ألف دنار وحطتهم دولار + +233 +00:19:02,960 --> 00:19:09,640 +ليهم، مش هيسوي إشي لكن if she invest it means the + +234 +00:19:09,640 --> 00:19:12,700 +investment will exceed the value of the + +235 +00:19:12,700 --> 00:19:16,480 +diminishing اللي هو ال 105 المفروض، فال 106 صار + +236 +00:19:16,480 --> 00:19:18,680 +عندنا دولار واحد زيادة + +237 +00:19:21,320 --> 00:19:25,100 +بالتالي، في المستقبل، ستحصل على أكتر من 1 دولار + +238 +00:19:25,100 --> 00:19:30,880 +كما قلنا أننا 100 دولار لازم تكون أكتر من الدولار + +239 +00:19:30,880 --> 00:19:35,560 +اللي هينخفض كما أنك ستحصل على الانترست على انتقالك + +240 +00:19:35,560 --> 00:19:39,800 +وانتقالك الانتقال الانتقالي الدولار هناك تجارب + +241 +00:19:39,800 --> 00:19:43,900 +ريسكت ريتين، هذا هو الرقم الثاني الرقم الثاني + +242 +00:19:48,130 --> 00:19:51,990 +we only take risk when we expect to be compensated + +243 +00:19:51,990 --> 00:19:56,110 +for the extra risk with additional return طيب + +244 +00:19:56,110 --> 00:20:02,690 +خلّيني أعطيكم مثال مثال بسيط جدا very simple وهنا + +245 +00:20:02,690 --> 00:20:05,870 +بتسير المشاكل اللي عندنا في غزة كتير وانا بحب أركز + +246 +00:20:05,870 --> 00:20:10,570 +برا تحت some local stories واحد بقال جالك تعالي + +247 +00:20:10,570 --> 00:20:12,670 +استثمر معايا قلنا له okay قدرش تعطينا؟ هو بيقولك + +248 +00:20:12,670 --> 00:20:18,710 +عشرة في المية okayطب واحد عنده tunnels بيستثمر بال + +249 +00:20:18,710 --> 00:20:23,990 +tunnels طب ال tunnels مخاطر ولا لأ؟ مخاطر جداش + +250 +00:20:23,990 --> 00:20:28,510 +الاستثمار بيعطيك 200% يعني العشر تلاف دولار بتعمل + +251 +00:20:28,510 --> 00:20:32,890 +عشرين ألف دولار احنا we look at the benefits only + +252 +00:20:32,890 --> 00:20:35,570 +احنا بننظر على ال benefits we are not looking at + +253 +00:20:35,570 --> 00:20:39,680 +the riskلأنه بيجي الزلمة هذا بصرخ بعد يومين ايه + +254 +00:20:39,680 --> 00:20:42,380 +مصارية راحت و اه مصارية يعني الزلمة جابلنا كاميون + +255 +00:20:42,380 --> 00:20:45,580 +بشوفه انا very relaxed يعني بتطلع فيه لأنه زي + +256 +00:20:45,580 --> 00:20:51,050 +الطبيب اللي بيشوف مريضالطبيب بتعامل مع المريض ان + +257 +00:20:51,050 --> 00:20:54,910 +هو مريض بالاخير patient وهذا ال case الموجود وهذا + +258 +00:20:54,910 --> 00:20:58,310 +الإنسان اللى وجع في مشكلة وراحت مصري اه I look at + +259 +00:20:58,310 --> 00:21:01,730 +him صحيح my heart with him but this is the real + +260 +00:21:01,730 --> 00:21:05,630 +case هذا وضع طبيعي سير ليش because you invest your + +261 +00:21:05,630 --> 00:21:11,450 +money in a risky asset and because of this you are + +262 +00:21:11,450 --> 00:21:15,030 +in this caseوانت في هذه الحالة يعني you invest + +263 +00:21:15,030 --> 00:21:18,650 +your money يعني مثلا قبل من يومين واحد حاطط مصاريف + +264 +00:21:18,650 --> 00:21:23,390 +في .. في شغل كتير خطرة في استثمار واحد جايله قعدت + +265 +00:21:23,390 --> 00:21:26,590 +أربعين ألف دولار وانا برفحك خلال يومين في .. بدون + +266 +00:21:26,590 --> 00:21:29,830 +بيشتريه شغلات معينة مثلا بال .. بدون تجاهات مش + +267 +00:21:29,830 --> 00:21:33,030 +موجودة في السوق بعطيك فوقيهم كمان أربعين ألف دولار + +268 +00:21:33,030 --> 00:21:37,510 +وراحوا البضاعة ماوستطعتش وراحوا الأربعين ألف دولار + +269 +00:21:37,510 --> 00:21:41,880 +that's itلكن هدول 30 thousand دولار if you put in + +270 +00:21:41,880 --> 00:21:46,580 +the supermarket يعني مش صعب ي .. صعب يروحوا والله + +271 +00:21:46,580 --> 00:21:49,680 +إذا أنت حاططهم في مثلا if you invest in مثلا + +272 +00:21:49,680 --> 00:21:52,460 +حاططهم مرابحة في البنك because it is a very secure + +273 +00:21:52,460 --> 00:21:58,380 +مش هيروح فهذا ال risk if you are asking for higher + +274 +00:21:58,380 --> 00:22:02,180 +return you have to hold higher riskبقى المشكلة أن + +275 +00:22:02,180 --> 00:22:05,080 +بعض الناس تبقى قادة في عقلها إن كنت أريد أن أحافظ + +276 +00:22:05,080 --> 00:22:08,260 +على أعلى ريسك أو عقل أعلى، فهذا يعني أنه يجب أن + +277 +00:22:08,260 --> 00:22:11,000 +أحافظ على أعلى ريسك أو عقل أعلى، فهذا يعني أنه يجب + +278 +00:22:11,000 --> 00:22:11,640 +أن أحافظ على أعلى ريسك أو عقل أعلى، فهذا يعني أنه + +279 +00:22:11,640 --> 00:22:12,860 +يجب أن أحافظ على أعلى ريسك أو عقل أعلى، فهذا يعني + +280 +00:22:12,860 --> 00:22:16,440 +أنه يجب أن أحافظ على أعلى ريسك أو عقل أعلى، فهذا + +281 +00:22:16,440 --> 00:22:21,060 +يعني أنه يجب + +282 +00:22:21,060 --> 00:22:24,240 +أن أحافظ على أعلى ريسك أو عقل أعلى، فهذا يعني أنه + +283 +00:22:24,240 --> 00:22:33,550 +يجب أن أحافظ على أيعني بطريقة أخرى أنه قد يفقد 60 + +284 +00:22:33,550 --> 00:22:40,410 +ألف دولار هذا هو عليك أن تشاهد الصورة الواضحة ليس + +285 +00:22:40,410 --> 00:22:46,230 +بالنسبة لجمال ال 60 ألف دولار عليك أن تشاهد قيمة + +286 +00:22:46,230 --> 00:22:51,690 +ال 60 ألف دولار المفقودة هذا هو المخاطر لماذا هو + +287 +00:22:51,690 --> 00:22:53,970 +المخاطر؟ لأننا غير متأكدين + +288 +00:22:56,510 --> 00:22:59,190 +to take sixty thousand dollar if we are certain + +289 +00:22:59,190 --> 00:23:03,290 +خدوا باعكوا إذا هذا متأكد هذا عرض عليك العرض و قال + +290 +00:23:03,290 --> 00:23:06,970 +لك أنا بعرف if he certain that he will make sixty + +291 +00:23:06,970 --> 00:23:11,970 +thousand dollar he may not coming to you شفتوا + +292 +00:23:11,970 --> 00:23:15,090 +كيف؟ إذا هو متأكد مية في المية هيعمل ستين ألف + +293 +00:23:15,090 --> 00:23:19,070 +دولار مش هيجيك so why he or she coming to you + +294 +00:23:19,070 --> 00:23:23,730 +because he is uncertainلتصبح 60 ألف دولار أو + +295 +00:23:23,730 --> 00:23:28,270 +لتخسره 60 ألف دولار لذلك هو يأتي إليك كبير كبير + +296 +00:23:28,270 --> 00:23:30,770 +كبير كبير كبير كبير كبير كبير كبير كبير كبير كبير + +297 +00:23:30,770 --> 00:23:31,290 +كبير كبير كبير كبير كبير كبير كبير كبير كبير كبير + +298 +00:23:31,290 --> 00:23:31,430 +كبير كبير كبير كبير كبير كبير كبير كبير كبير كبير + +299 +00:23:31,430 --> 00:23:34,590 +كبير كبير كبير كبير كبير كبير كبير كبير كبير كبير + +300 +00:23:34,590 --> 00:23:37,430 +كبير كبير كبير كبير كبير كبير كبير كبير كبير كبير + +301 +00:23:37,430 --> 00:23:40,770 +كبير كبير كبير كبير كبير كبير كبير كبير كبير كبير + +302 +00:23:40,770 --> 00:23:44,210 +كبير + +303 +00:23:44,210 --> 00:23:47,910 +كب + +304 +00:23:49,040 --> 00:23:55,120 +وهذا يمكنك أن تخسر 5 ألف دولار هنا إذا كنت تخسر + +305 +00:23:55,120 --> 00:24:09,260 +البرمجة 60 ÷ 40 فهنا 3 وهنا 20 لديك 1.150 + +306 +00:24:09,260 --> 00:24:15,540 +% الأربعة ستكون 150% لكن انظر هنا احتمالات الخسارة + +307 +00:24:15,540 --> 00:24:25,860 +كم؟ 5 على 40يعني تمن، شيء بسيط، because the + +308 +00:24:25,860 --> 00:24:32,320 +uncertainty is minimized الاحتمالية عدم التأكد + +309 +00:24:32,320 --> 00:24:38,040 +انخفضت this is why investors are risk-averse ال + +310 +00:24:38,040 --> 00:24:42,180 +investors مالهم بتجنبوا المخاطر if you are more + +311 +00:24:42,180 --> 00:24:46,320 +risk-averse it means you are less likely to lose + +312 +00:24:46,320 --> 00:24:50,880 +your moneyيعني انت احتمالات تخسر هتكون ضعيفة زي ما + +313 +00:24:50,880 --> 00:24:54,860 +احنا شوفنا هان تربح 5000 دولار هذا الزلمة يعني + +314 +00:24:54,860 --> 00:25:00,700 +متأكد درجة كبيرة انه 5000 دولار يحصل عليهم okay + +315 +00:25:00,700 --> 00:25:04,040 +فكل ما احنا بدرجة التأكد بتزيد كل ما الأرباح + +316 +00:25:04,040 --> 00:25:08,780 +تبعتنا بتنخفض و الخسائر تبعتنا بتنخفض مش كل + +317 +00:25:08,780 --> 00:25:16,070 +البورصة طبعا الاسهم مش كلها اغلبها من وجهة نظركأه + +318 +00:25:16,070 --> 00:25:20,270 +higher risk فى عندنا higher risk و في عندنا lower + +319 +00:25:20,270 --> 00:25:23,090 +risk it depends on the on the stock itself + +320 +00:25:23,090 --> 00:25:30,510 +according to your question you + +321 +00:25:30,510 --> 00:25:41,070 +should think in this way this + +322 +00:25:41,070 --> 00:25:45,660 +is the risk and this is the returnالكثير من + +323 +00:25:45,660 --> 00:25:50,300 +المخاطر التي تحملها أكتر إجابة لديك لذلك إذا قمنا + +324 +00:25:50,300 --> 00:25:54,980 +بمقارنة A مع B هذا مصدر A وهذا مصدر B أيه يحمل + +325 +00:25:54,980 --> 00:26:03,600 +المخاطر الأكتر؟ B لأنك تحمل المخاطر الأكترهنا ثم a + +326 +00:26:03,600 --> 00:26:07,060 +الmarket الاجتماعي تجمعك مع اعضاء اعضاء اعضاء + +327 +00:26:07,060 --> 00:26:08,320 +اعضاء اعضاء اعضاء اعضاء اعضاء اعضاء اعضاء اعضاء + +328 +00:26:08,320 --> 00:26:11,420 +اعضاء اعضاء اعضاء اعضاء اعضاء اعضاء اعضاء اعضاء + +329 +00:26:11,420 --> 00:26:12,480 +اعضاء اعضاء اعضاء اعضاء اعضاء اعضاء اعضاء اعضاء + +330 +00:26:12,480 --> 00:26:14,200 +اعضاء اعضاء اعضاء اعضاء اعضاء اعضاء اعضاء اعضاء + +331 +00:26:14,200 --> 00:26:15,360 +اعضاء اعضاء اعضاء اعضاء اعضاء اعضاء اعضاء اعضاء + +332 +00:26:15,360 --> 00:26:22,760 +اعضاء اعضاء اعضاء اعضاء اعضاء اعضاء اعضاء اعضاء ا + +333 +00:26:24,440 --> 00:26:28,520 +والعادة الأقل إذا تنظر إلى هنا هذا لا عدد عدد عدد + +334 +00:26:28,520 --> 00:26:29,360 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +335 +00:26:29,360 --> 00:26:30,440 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +336 +00:26:30,440 --> 00:26:30,580 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +337 +00:26:30,580 --> 00:26:30,640 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +338 +00:26:30,640 --> 00:26:33,760 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +339 +00:26:33,760 --> 00:26:46,920 +عدد عدد عدد عدد عدد عد + +340 +00:26:48,890 --> 00:26:52,570 +وانظر إلى هنا هذا هو الاتجار المتوقع لأخذ أداء + +341 +00:26:52,570 --> 00:26:58,690 +أضافى فهذا أداء أضافى الذي تحملينه و لأن هذا أداء + +342 +00:26:58,690 --> 00:27:05,490 +أضافى مجتمعك قام بتجاربك لأداء أضافى اضافى اضافى + +343 +00:27:05,490 --> 00:27:10,790 +اضافى اضافى اضافى اضافى اضافى اضافى اضافى اضافى + +344 +00:27:10,790 --> 00:27:10,970 +اضافى اضافى اضافى اضافى اضافى اضافى اضافى اضافى + +345 +00:27:10,970 --> 00:27:11,410 +اضافى اضافى اضافى اضافى اضافى اضافى اضافى اضافى + +346 +00:27:11,410 --> 00:27:17,050 +اضافى اضافى اضافى اض + +347 +00:27:18,040 --> 00:27:22,700 +يعني اللي بده يروح يستثمر في هاي يروح يحط مصاري + +348 +00:27:22,700 --> 00:27:27,100 +with unknown investment or certain investments I + +349 +00:27:27,100 --> 00:27:32,620 +think from my point of view he should reserve the + +350 +00:27:32,620 --> 00:27:37,260 +ICU unit in the Al Shafia hospital و الله trust me + +351 +00:27:37,260 --> 00:27:42,560 +sooner or later اللي بيستثمر في استثمارات خاطرة + +352 +00:27:44,450 --> 00:27:48,910 +يحاول أنه يتأكد أن غرف ال ICU محجوزة له في + +353 +00:27:48,910 --> 00:27:56,650 +المستقبل لأن المال عزيز على الناس تمام؟ المال عزيز + +354 +00:27:56,650 --> 00:28:02,750 +على الناس و أنا شوفت أمثلة كثيرة أمثلة كثيرة بيكون + +355 +00:28:02,750 --> 00:28:06,410 +بنا آدم طبيعي و بيستثمر و تقوله يا بنا آدم هتجرب + +356 +00:28:06,410 --> 00:28:09,350 +على الشغل اوه انت مش بتفهم انت بالكلام هذا بالاخير + +357 +00:28:09,350 --> 00:28:15,800 +بتعرف انه زنب في المستشفىلأ مجنين كثير هيك بال + +358 +00:28:15,800 --> 00:28:20,620 +heart attack اه لأنه المشكلة تروح واحد يعني اذا ما + +359 +00:28:20,620 --> 00:28:24,040 +اعطيتكوا مثال جابلنا كام يوم واحد ماخد ال .. تبع + +360 +00:28:24,040 --> 00:28:27,540 +الوكالة اللي هو ال .. ايش بيسموه الادخار تبع + +361 +00:28:27,540 --> 00:28:32,480 +الوكالة تبعه ورايح يستثمر فيه في شغلات خاطرة الزنا + +362 +00:28:32,480 --> 00:28:35,960 +ما بده يعمل big hit يعني طيب و بعدين راحوا المصاري + +363 +00:28:35,960 --> 00:28:38,660 +عليه و اين بده يسطح هذا البن آدم؟ اه + +364 +00:28:41,110 --> 00:28:44,650 +فبين المشكلة؟ المشكلة أنه هو .. he .. he doesn't + +365 +00:28:44,650 --> 00:28:46,810 +understand there is a relationship between risk + +366 +00:28:46,810 --> 00:28:49,790 +and return مش فاهم العلاقة هذه he just understands + +367 +00:28:49,790 --> 00:28:54,790 +if I have higher return I will still keep the + +368 +00:28:54,790 --> 00:28:59,110 +minimum risk هذه ال story الموجودة في راسه okay + +369 +00:28:59,110 --> 00:29:01,570 +عشان هيك لما احنا بنشوف هدول these people يعني + +370 +00:29:01,570 --> 00:29:05,990 +احنا it's okay you lose your money ف this is the + +371 +00:29:05,990 --> 00:29:10,710 +storyولكن الناس تعرفوا عن هذه الحكومة في النهاية، + +372 +00:29:10,710 --> 00:29:18,150 +في الأخير لم يعرفوا عن هذه الحكومة ومع ذلك الـ + +373 +00:29:18,150 --> 00:29:22,370 +Cash flows of the brands هم مصادر القيم دعونا قبل + +374 +00:29:22,370 --> 00:29:30,810 +أن نغادر تفكيركم بالأمر الثالث نحن عندما نتكلم عن + +375 +00:29:30,810 --> 00:29:35,120 +cash flow يجب أن نركز على اتنين أشياءالجزء + +376 +00:29:35,120 --> 00:29:39,260 +التعليمي من المال المجتمعي والمجتمع الاجتماعي + +377 +00:29:39,260 --> 00:29:45,200 +والمجتمع الاجتماعي والمجتمع الاجتماعي والمجتمع + +378 +00:29:45,200 --> 00:29:49,940 +الاجتماعي ومجتمع الاجتماعي ومجتمع الاجتماعي ومجتمع + +379 +00:29:49,940 --> 00:29:55,340 +الاجتماعي ومجتمع الاجتماعي ومجتمع الاجتماعي ومجتمع + +380 +00:29:55,340 --> 00:29:57,120 +الاجتماعي ومجتمع الاجتماعي ومجتمع الاجتماعي ومجتمع + +381 +00:29:57,120 --> 00:29:57,180 +الاجتماعي ومجتمع الاجتماعي ومجتمع الاجتماعي ومجتمع + +382 +00:29:57,180 --> 00:30:03,080 +الاجتماعي ومجتمع الاجتماعي ومجتمع الاجتماعي ومجتمع + +383 +00:30:03,080 --> 00:30:04,460 +الاجتما + +384 +00:30:10,210 --> 00:30:12,590 +هل المستثمرين بيركزوا على ال profit و لا على ال + +385 +00:30:12,590 --> 00:30:17,030 +cash؟ على ال profit، حسنًا، فبالنسبة لك، + +386 +00:30:17,030 --> 00:30:21,210 +المستثمرين يبحثون عن ال profit، وهو غير صحيح + +387 +00:30:21,210 --> 00:30:27,090 +تمامًا، لماذا؟ لأن ال profit مخطئ، هل هو صح؟ ال + +388 +00:30:27,090 --> 00:30:32,850 +profit مهم، لكن ليس إلى مدى ما يتجه إلى مهمة ال + +389 +00:30:32,850 --> 00:30:33,230 +cash + +390 +00:30:36,210 --> 00:30:41,390 +why؟ why؟ is like if we have one hundred dollar as + +391 +00:30:41,390 --> 00:30:48,450 +a profit this is as a paper profit you see this is + +392 +00:30:48,450 --> 00:30:53,570 +paper profit this is in the accounting but cash it + +393 +00:30:53,570 --> 00:30:58,850 +is real you have cashلنرى على سبيل المثال هذا + +394 +00:30:58,850 --> 00:31:02,630 +المثال إذا كان لديك سامسونج هاتف موبايل و قررت أن + +395 +00:31:02,630 --> 00:31:08,210 +تشتري هذا لتساوي هذا السامسونج 300 دولار الآن + +396 +00:31:08,210 --> 00:31:15,350 +سأطلب منك وشترته في 250 دولار لذلك تجعل 50 دولار + +397 +00:31:15,350 --> 00:31:20,750 +حسنًا؟ الأن دعنا نعتبر هذه الحالة شترت 250 دولار + +398 +00:31:20,750 --> 00:31:27,000 +وشترت هذا في 350 دولار لذلك تجعل 50 دولارmy + +399 +00:31:27,000 --> 00:31:31,440 +question is to you did you receive cash؟ هل انتوا + +400 +00:31:31,440 --> 00:31:37,280 +بعتوا cash؟ this is questionableبيقولي لأ I only + +401 +00:31:37,280 --> 00:31:41,980 +receive one hundred dollar أنا ميتها الدولار and + +402 +00:31:41,980 --> 00:31:45,900 +she promise me to pay it later بيقولك okay because + +403 +00:31:45,900 --> 00:31:49,140 +she promise you you do this you bought it two + +404 +00:31:49,140 --> 00:31:52,540 +hundred fifty now you only have one hundred dollar + +405 +00:31:52,540 --> 00:31:57,360 +so you have one hundred minus you have minus one + +406 +00:31:57,360 --> 00:32:00,140 +hundred fifty dollar cash you are in deficit now + +407 +00:32:00,140 --> 00:32:06,660 +انت عندك عجزDo you have real profit؟ عندك real + +408 +00:32:06,660 --> 00:32:10,700 +profit؟ فش انت ال galaxy تبعكم انتوا اشتريتهوا 250 + +409 +00:32:10,700 --> 00:32:15,420 +$ بيعتوه 300 بال paper بالورق بس صح ولا لأ ارباحكم + +410 +00:32:15,420 --> 00:32:19,500 +بال paper 50$ بقى in real انتوا في جيبتكوا دخل 150 + +411 +00:32:19,500 --> 00:32:27,300 +$ ودفعتوا 250$ اه ودفعتوا اخدتوا 100$ فصفة انه + +412 +00:32:27,300 --> 00:32:34,030 +انتوا deficit معاكوا عاجز 150$لما ال customer يدفع + +413 +00:32:34,030 --> 00:32:37,610 +كسعيتها, we consider this. So this is the problem + +414 +00:32:37,610 --> 00:32:41,390 +of cash. So generally speaking, to extend the + +415 +00:32:41,390 --> 00:32:45,170 +profit, generate cash, this is the issue. Okay, so + +416 +00:32:45,170 --> 00:32:48,090 +we stop here and think on the economic things of + +417 +00:32:48,090 --> 00:32:51,590 +incremental and the profit and on Saturday we will + +418 +00:32:51,590 --> 00:32:55,190 +finish chapter one, okay؟ دي هتكمل عادي + diff --git a/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/BQGlVtONd7I_postprocess.srt b/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/BQGlVtONd7I_postprocess.srt new file mode 100644 index 0000000000000000000000000000000000000000..58d3fb1763d6bcefe35296b001b25cb0a5fec460 --- /dev/null +++ b/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/BQGlVtONd7I_postprocess.srt @@ -0,0 +1,1920 @@ +1 +00:00:19,480 --> 00:00:22,800 +لقاء الماضي كنا نحكي بال .. بال income statements + +2 +00:00:22,800 --> 00:00:26,620 +و ال .. ال components of the income statements + +3 +00:00:26,620 --> 00:00:31,120 +خلينا بس أنه أنا أذكركم just remind you in the + +4 +00:00:31,120 --> 00:00:35,520 +main account in the income statements بس .. بسمع + +5 +00:00:35,520 --> 00:00:39,460 +بعض تذكر ال .. الحسابات الرئيسية بال income + +6 +00:00:39,460 --> 00:00:44,100 +statements احنا كنا نبدأ بال sales okay we start + +7 +00:00:44,100 --> 00:00:51,300 +sales then we deduct the cost ofquotes of goods + +8 +00:00:51,300 --> 00:00:55,620 +sold بطلع + +9 +00:00:55,620 --> 00:01:01,580 +لنا ل gross ل profits then we deduct the operating + +10 +00:01:01,580 --> 00:01:06,300 +expenses expenses + +11 +00:01:06,300 --> 00:01:09,000 +so we have operating + +12 +00:01:13,310 --> 00:01:22,550 +income so we deduct the interest I so we get the + +13 +00:01:22,550 --> 00:01:29,950 +pre-tax income or EBT evening before tax which is + +14 +00:01:29,950 --> 00:01:36,530 +this the same then we deduct the tax we end with + +15 +00:01:36,530 --> 00:01:43,250 +net incomeOkay? So this is the story of preparing + +16 +00:01:43,250 --> 00:01:47,190 +the income statement Now, for the income statement + +17 +00:01:47,190 --> 00:01:52,050 +for the net income how we manage the net income? + +18 +00:01:53,210 --> 00:01:58,570 +So net income here generally we have two main + +19 +00:01:58,570 --> 00:02:03,930 +policies to think on the income statement or in + +20 +00:02:03,930 --> 00:02:11,210 +the income profits The first one isلتدفعهم .. + +21 +00:02:11,210 --> 00:02:19,130 +تدفعهم كدفع .. دفع أو لتدفع .. لتدفع .. لتدفع .. + +22 +00:02:19,130 --> 00:02:23,890 +لتدفع .. لتدفع .. لتدفع .. لتدفع .. لتدفع .. لتدفع + +23 +00:02:23,890 --> 00:02:27,210 +.. لتدفع .. لتدفع .. لتدفع .. لتدفع .. لتدفع .. + +24 +00:02:27,210 --> 00:02:27,310 +لتدفع .. لتدفع .. لتدفع .. لتدفع .. لتدفع .. لتدفع + +25 +00:02:27,310 --> 00:02:28,450 +لتدفع .. لتدفع .. لتدفع .. لتدفع .. لتدفع .. لتدفع + +26 +00:02:28,450 --> 00:02:35,890 +.. لتدفع .. لتدفع .. لتدفع + +27 +00:02:38,670 --> 00:02:43,770 +Okay, so let's consider this case if we look at + +28 +00:02:43,770 --> 00:02:48,790 +When + +29 +00:02:48,790 --> 00:02:53,330 +we evaluate any stock R, this is the return of a + +30 +00:02:53,330 --> 00:02:58,070 +particular stock R the return of a particular + +31 +00:02:58,070 --> 00:03:07,030 +stock which is equal the dividends yield plus + +32 +00:03:07,940 --> 00:03:11,280 +السيارات السياسية، فالسيارات السياسية تأتي من + +33 +00:03:11,280 --> 00:03:17,800 +الاستثمار، وهو السيارات السياسية من + +34 +00:03:17,800 --> 00:03:22,720 +نظر المعرفة، مرة أخرى، هذا هو R، الدفع هو دفع + +35 +00:03:22,720 --> 00:03:30,590 +تقرير D مقاطع B نوتD هي الدفعات وP0 هي الأسعار في + +36 +00:03:30,590 --> 00:03:38,890 +أسعار الأشعار plus P1 minus P0 divided by P0 انظر + +37 +00:03:38,890 --> 00:03:44,370 +إلى هذه الاثنين السيطرات الأولى دفعات تأثير على + +38 +00:03:44,370 --> 00:03:50,990 +هذا الجزء الـ return earnings تأثير على هذا الجزء + +39 +00:03:53,720 --> 00:04:00,160 +بعض المستخدمين يبحثون عن ميزة الميزة والمستخدمين + +40 +00:04:00,160 --> 00:04:06,340 +يبحثون عن ميزة الميزة المالية هذا هو السبب في أن + +41 +00:04:06,340 --> 00:04:14,280 +الشركات يكونوا حذرين في إتجار كمية تدفع وكمية تدفع + +42 +00:04:14,280 --> 00:04:19,920 +ميزة للميزة لأنها تأثر على ميزة الميزة وميزة + +43 +00:04:19,920 --> 00:04:24,160 +الميزة وميزة الميزة وميزة الميزة وميزة الميزةعن + +44 +00:04:24,160 --> 00:04:29,500 +سبيل المثال، إذا قررنا أن ندفع نصف دفعات ونبقى كل + +45 +00:04:29,500 --> 00:04:38,660 +أرباحنا، فسنحفظ هذا، لكن في الاخرى، إذا قررنا أن + +46 +00:04:38,660 --> 00:04:48,030 +نبقى لا أرباح، فسنحفظ هذابعض المديرين يقومون + +47 +00:04:48,030 --> 00:04:49,770 +بإزالة ما بين اتصالات الاساسية بين الاتصالات + +48 +00:04:49,770 --> 00:04:51,290 +الاساسية بين الاتصالات الاساسية بين الاتصالات + +49 +00:04:51,290 --> 00:04:53,390 +الاساسية بين الاتصالات الاساسية بين الاتصالات + +50 +00:04:53,390 --> 00:04:53,930 +الاساسية بين الاتصالات الاساسية بين الاتصالات + +51 +00:04:53,930 --> 00:04:54,390 +الاساسية بين الاتصالات الاساسية بين الاتصالات + +52 +00:04:54,390 --> 00:05:00,250 +الاساسية بين الاتصالات الاساسية بين الاتصالات + +53 +00:05:00,250 --> 00:05:02,490 +الاساسية بين الاتصالات الاساسية بين الاتصالات + +54 +00:05:02,490 --> 00:05:03,670 +الاساسية بين الاتصالات الاساسية بين الاتصالات + +55 +00:05:03,670 --> 00:05:03,770 +الاساسية بين الاتصالات الاساسية بين الاتصالات + +56 +00:05:03,770 --> 00:05:09,650 +الاساسية بين الاتصالات ال + +57 +00:05:14,380 --> 00:05:22,940 +إذا كان لدينا رجل قديم ورحل وعمره 60 سنة، فهو في + +58 +00:05:22,940 --> 00:05:30,640 +عمره 60 سنة هذا الرجل يفضل دفعات أو عودة دفعات، + +59 +00:05:30,640 --> 00:05:34,940 +دفعات، دفعات، دفعات، دفعات، دفعات، دفعات، دفعات، + +60 +00:05:34,940 --> 00:05:35,100 +دفعات، دفعات، دفعات، دفعات، دفعات، دفعات، دفعات، + +61 +00:05:35,100 --> 00:05:35,120 +دفعات، دفعات، دفعات، دفعات، دفعات، دفعات، دفعات، + +62 +00:05:35,120 --> 00:05:39,440 +دفعات، دفعات، دفعات، دفعات، دفعات، دف + +63 +00:05:42,020 --> 00:05:45,320 +focus on this dividends or in return earnings + +64 +00:05:45,320 --> 00:05:49,120 +still in dividends okay let's take another example + +65 +00:05:49,120 --> 00:05:56,980 +a businessman with 40 years old where + +66 +00:05:56,980 --> 00:06:01,960 +he focus in return earnings he prefer the capital + +67 +00:06:01,960 --> 00:06:09,420 +gains okayالفرق الرئيسي مع 50 سنة والرجل مع 60 سنة + +68 +00:06:09,420 --> 00:06:14,880 +يحتاج إلى المال، يحتاج إلى المدفعات لتأكيد حياته + +69 +00:06:14,880 --> 00:06:18,660 +أو حياته، فبعض المستخدمين، مرة أخرى، بعض + +70 +00:06:18,660 --> 00:06:23,020 +المستخدمين يبحثون عن المدفعات لأنه يعتمد على + +71 +00:06:23,020 --> 00:06:27,120 +الموضوع والمستخدمين الآخرين يبحثون عن الميزة، مرة + +72 +00:06:27,120 --> 00:06:33,230 +أخرى، يعتمد على الموضوعلذلك الشركات ترغب في تحقيق + +73 +00:06:33,230 --> 00:06:38,410 +أو توفير نظرية المستخدمين لدينا نظرية مختلفة لدينا + +74 +00:06:38,410 --> 00:06:42,530 +نحتاجات مختلفة لذلك يجب أن نتعامل مع كل هذه + +75 +00:06:42,530 --> 00:06:46,990 +الاحتياطات باستخدام فهم كيف نشتري الانتجار + +76 +00:06:46,990 --> 00:06:50,050 +الانتجار الانتجار الانتجار بين الانتجارات والدفعات + +77 +00:06:50,050 --> 00:06:50,610 +الانتجار الانتجار الانتجار الانتجار الانتجار + +78 +00:06:50,610 --> 00:06:52,010 +الانتجار الانتجار الانتجار الانتجار الانتجار + +79 +00:06:52,010 --> 00:06:53,430 +الانتجار الانتجار الانتجار الانتجار الانتجار + +80 +00:06:53,430 --> 00:06:54,410 +الانتجار الانتجار الانتجار الانتجار الانتجار + +81 +00:06:54,410 --> 00:06:58,690 +الانتجار + +82 +00:06:58,690 --> 00:07:02,780 +الانالـ Return Earnings Year، إذا تنظر إلى الـ + +83 +00:07:02,780 --> 00:07:06,380 +Return Earnings، الـ Return Earnings تبقى موجودة + +84 +00:07:06,380 --> 00:07:10,160 +في ال .. في الـ Balance Sheet، ف .. ف .. فنفهم + +85 +00:07:10,160 --> 00:07:14,880 +الفرق بين الـ Dividends Yield و الـ Capital Gains، + +86 +00:07:14,880 --> 00:07:21,500 +هل هذا واضح الأن؟ حسنًا، دعنا نرى الاتصال بين الـ + +87 +00:07:21,500 --> 00:07:29,620 +Income Statement و الـ Balance Sheetخلّيني أشوف ال + +88 +00:07:29,620 --> 00:07:37,460 +income statement and the balance sheet let's + +89 +00:07:37,460 --> 00:07:46,560 +go back again this is the net income we + +90 +00:07:46,560 --> 00:07:49,140 +say this is dividends and this is return earnings + +91 +00:07:49,140 --> 00:07:55,060 +if you look at the balance sheet statement so this + +92 +00:07:55,060 --> 00:07:57,480 +is the balance sheet statement here is the asset + +93 +00:07:58,240 --> 00:08:04,200 +and here is the liabilities and as we said before + +94 +00:08:04,200 --> 00:08:09,420 +this is quarters, this is current assets and here + +95 +00:08:09,420 --> 00:08:13,200 +current liabilities, fixed assets, long term + +96 +00:08:13,200 --> 00:08:15,900 +liabilities and equity + +97 +00:08:18,810 --> 00:08:22,810 +لذلك الـ Return Earnings والتواصل بين الـ Net + +98 +00:08:22,810 --> 00:08:26,870 +Income و الـ Balance Sheet الـ Return Earnings يتم + +99 +00:08:26,870 --> 00:08:32,910 +تضمينه في الـ Balance Sheet حسنا؟ لذلك نعتبر هذا + +100 +00:08:32,910 --> 00:08:43,070 +كجزء معين، كجزء مهم في ال .. في الاستثمار حسنا، + +101 +00:08:43,070 --> 00:08:47,720 +لذلك الـ Return Earnings هنافي هذا المكان، يعطي + +102 +00:08:47,720 --> 00:08:57,620 +فرصة لعملية تدفع هذه الجزيرة فإذا + +103 +00:08:57,620 --> 00:09:05,180 +الـ 10 أعصاب تأتي من الـ Net Income كإيقوة، فإذا + +104 +00:09:05,180 --> 00:09:09,820 +كان لدينا فرصة لتدفع لوقت طويل، لأن هنا هي فرصة + +105 +00:09:09,820 --> 00:09:17,930 +للدفع، فلدينا مصالح أو مصالح كافيةالعامة من هذه + +106 +00:09:17,930 --> 00:09:21,030 +الجزيرة من الـ Return Earnings لذا ما أريد أن + +107 +00:09:21,030 --> 00:09:26,670 +أقوله في هذه الجزيرة عامة عامة عامة عامة عامة عامة + +108 +00:09:26,670 --> 00:09:27,810 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +109 +00:09:27,810 --> 00:09:29,170 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +110 +00:09:29,170 --> 00:09:29,390 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +111 +00:09:29,390 --> 00:09:32,790 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +112 +00:09:32,790 --> 00:09:43,210 +عامة عامة عامة عامة عامة عامة عامة عامة + +113 +00:09:43,210 --> 00:09:50,640 +عوالمقالات أو المال أو المدفوعات، سنرى أن الـ + +114 +00:09:50,640 --> 00:09:55,660 +Retail Earnings أقل من أي عملية أخرى، هذا هو السبب + +115 +00:09:55,660 --> 00:10:00,980 +لمجموعة يفضلون أن تحتفظ بأموالها بدل أن تدفعهم، + +116 +00:10:00,980 --> 00:10:07,160 +لذلك هذا هو الاتصال بين الوصفات الدفعية ومقالات + +117 +00:10:07,160 --> 00:10:08,500 +الدفعية، هل هناك أسئلة؟ + +118 +00:10:11,920 --> 00:10:14,760 +كما أشرح هنا، ماذا يمكن للشركة أن تفعل مع الـ Net + +119 +00:10:14,760 --> 00:10:17,860 +Income؟ كما أشرح في هذا البرنامج، تدفع المال + +120 +00:10:17,860 --> 00:10:22,420 +وانتقل للشركات وإذا + +121 +00:10:22,420 --> 00:10:26,340 +تنظر إلى هذا المثال هنا، تحقق مثال واحد واثنين إذا + +122 +00:10:26,340 --> 00:10:31,100 +نعود إلى مثال واحد واثنين، فانتقل إلى مثل واحد فقط + +123 +00:10:31,100 --> 00:10:33,960 +تذكر في مقالات الشركة ونسبة الـ Net Income 90 + +124 +00:10:33,960 --> 00:10:40,900 +مليون فنحن لدينا 90 مليون هنا كنسبة Net Incomeوهي + +125 +00:10:40,900 --> 00:10:43,860 +لديها 35 مليون شيرات ممتازة، ماذا سيكون ال .. + +126 +00:10:43,860 --> 00:10:48,700 +حسنا، هذا مثال واحد مثال اتسابق اتسابق اتسابق + +127 +00:10:48,700 --> 00:10:48,900 +اتسابق اتسابق اتسابق اتسابق اتسابق اتسابق اتسابق + +128 +00:10:48,900 --> 00:10:49,100 +اتسابق اتسابق اتسابق اتسابق اتسابق اتسابق اتسابق + +129 +00:10:49,100 --> 00:10:53,320 +اتسابق اتسابق اتسابق اتسابق اتسابق اتسابق اتسابق + +130 +00:10:53,320 --> 00:11:03,780 +اتسابق اتسابق اتسابق اتسابق اتسابق اتسابق ا + +131 +00:11:04,180 --> 00:11:06,880 +العامات التي تستخدمها الـ Return هي نسبة نت + +132 +00:11:06,880 --> 00:11:10,860 +الانقام مقاومة نت الانقام 90 مقاومة مقاومة 20 + +133 +00:11:10,860 --> 00:11:12,200 +مقاومة مقاومة مقاومة مقاومة مقاومة مقاومة مقاومة + +134 +00:11:12,200 --> 00:11:16,180 +مقاومة مقاومة مقاومة مقاومة مقاومة مقاومة مقاومة + +135 +00:11:16,180 --> 00:11:17,340 +مقاومة مقاومة مقاومة مقاومة مقاومة مقاومة مقاومة + +136 +00:11:17,340 --> 00:11:17,440 +مقاومة مقاومة مقاومة مقاومة مقاومة مقاومة مقاومة + +137 +00:11:17,440 --> 00:11:21,160 +مقاومة مقاومة مقاومة مقاومة مقاومة مقاومة + +138 +00:11:21,160 --> 00:11:32,320 +مقاومة مقا + +139 +00:11:33,110 --> 00:11:38,970 +الـ income statement of Boswell دعونا نعود و نرى + +140 +00:11:38,970 --> 00:11:42,130 +انظروا + +141 +00:11:42,130 --> 00:11:45,750 +إلى هذه الاختصارات ما نفهمه من هذه الاختصارات + +142 +00:11:45,750 --> 00:11:50,150 +أولاً عندما تنظر إلى الـ income statement يجب أن + +143 +00:11:50,150 --> 00:11:54,890 +تركز على أربع موقعات الرئيسية أعني من المنطقة + +144 +00:11:54,890 --> 00:11:58,140 +الدولية و ليس من المنطقة الأساسيةI'm not looking + +145 +00:11:58,140 --> 00:12:03,100 +at how they arrange, how they locate, how they + +146 +00:12:03,100 --> 00:12:06,780 +calculate these statements I'm looking for four + +147 +00:12:06,780 --> 00:12:11,200 +main figures this is the first one the gross + +148 +00:12:11,200 --> 00:12:16,020 +profits then I will look at the net income which + +149 +00:12:16,020 --> 00:12:19,980 +is this one and I will look at the earnings before + +150 +00:12:19,980 --> 00:12:23,500 +tax this one and I will look at the net income + +151 +00:12:23,500 --> 00:12:29,400 +this oneهذه هي الأولى أو أهم .. أهم مصادر المصادر + +152 +00:12:29,400 --> 00:12:36,480 +المهمة في مصادر الميزانية الآن ما هي المهمة من هذه + +153 +00:12:36,480 --> 00:12:41,620 +المصادر؟ لكي نعرف المهمة من هذه المصادر، يجب أن + +154 +00:12:41,620 --> 00:12:46,900 +نقارن هذه المصادر مع السائقين على سبيل المثال، هذا + +155 +00:12:46,900 --> 00:12:49,680 +المصادر، الـ Gross Profits، نقارنه مع السائقين، + +156 +00:12:49,680 --> 00:12:54,700 +لنرى كيف تساعد السائقين في هذه المصادرwhy the + +157 +00:12:54,700 --> 00:12:59,980 +sales why sales is important yeah this this is a + +158 +00:12:59,980 --> 00:13:05,500 +question to you why sales is important because it + +159 +00:13:05,500 --> 00:13:08,280 +generated profit this is the first one okay what + +160 +00:13:08,280 --> 00:13:18,700 +else because it generated profits okay yes yes + +161 +00:13:18,700 --> 00:13:25,700 +because it is the main source of fundsوبسبب أنها + +162 +00:13:25,700 --> 00:13:30,600 +الرئيسية، تتمثل أكتر من مصادر الأموال في الشبكة، + +163 +00:13:30,600 --> 00:13:39,280 +حسنا؟ هذا .. هذا حسنًا، ماذا أخرى؟ نعم، + +164 +00:13:39,280 --> 00:13:45,780 +لأن السوق مرتبط بشركات المستخدمين والسوق مرتبط + +165 +00:13:45,780 --> 00:13:52,060 +بشركات المستخدمين وسوق مرتبط بشركات المستخدمين + +166 +00:13:52,060 --> 00:13:53,720 +وسوق مرتبط بشركات المستخدمين وسوق مرتبط بشركات + +167 +00:13:53,720 --> 00:13:58,360 +المستخدمينإذا كانت السيارات عالية، فهذا يعني أن + +168 +00:13:58,360 --> 00:14:04,840 +الشركة مقبولة للمستخدمين إذا كانت السيارات تتخلص، + +169 +00:14:04,840 --> 00:14:14,900 +فهذا يعني أن الشركة قد تحدي المشاكل، فالسيارات + +170 +00:14:14,900 --> 00:14:19,420 +تمنح الشركة إشعارات في الشركة أو إشعارات قديمة + +171 +00:14:19,420 --> 00:14:24,270 +للشركةإذا كانت السياسة بخير، فالعمل بخير، إذا لم + +172 +00:14:24,270 --> 00:14:28,650 +يكن السياسة بخير، فعلينا تحقق أسلوب التجارب أو + +173 +00:14:28,650 --> 00:14:31,710 +الأشياء التجاربية في العمل، لهذا السبب أن العمل + +174 +00:14:31,710 --> 00:14:37,160 +مهمنحن ننظر إلى الـ Gross Profits نقوم بتقارير هذه + +175 +00:14:37,160 --> 00:14:42,940 +الأشياء مع المخلوقات لنرى إفعالة وإفعالة المخلوقات + +176 +00:14:42,940 --> 00:14:46,780 +على سبيل المثال إذا كنا نتكلم عن Gross Profits هنا + +177 +00:14:46,780 --> 00:14:54,280 +ونقل 675 إلى 2700 + +178 +00:14:54,280 --> 00:15:03,400 +يعطي 25% إذا قمت بتقرير هذا على هذاما يعنيه 25% + +179 +00:15:03,400 --> 00:15:11,040 +يعني أن 1 دولار مستقبل في السوق يتجارب 25 دولار في + +180 +00:15:11,040 --> 00:15:19,440 +السوق كمحافظة عامة 25% يعني هنا 25 + +181 +00:15:19,440 --> 00:15:27,800 +% يعني 1 دولار في السوق يتجارب أو ينتج 25 دولار في + +182 +00:15:31,150 --> 00:15:31,950 +Okay, + +183 +00:15:34,350 --> 00:15:38,150 +we expect that this figure or this percentage to + +184 +00:15:38,150 --> 00:15:43,170 +be high to consume the other expenses because when + +185 +00:15:43,170 --> 00:15:49,040 +you go down, this rate diminishesdiminish، + +186 +00:15:49,040 --> 00:15:53,840 +gradually diminish it may reach to around 8% or 6% + +187 +00:15:53,840 --> 00:15:58,860 +so if this rate is high so the other expenses + +188 +00:15:58,860 --> 00:16:02,780 +eating less from the main account just try to + +189 +00:16:02,780 --> 00:16:06,100 +figure out what I'm saying here if for instance if + +190 +00:16:06,100 --> 00:16:11,860 +this is just only 15% we don't have room you know + +191 +00:16:11,860 --> 00:16:15,720 +room we don't have room we don't have not room + +192 +00:16:15,720 --> 00:16:20,530 +this roomwe don't have space yes yes so we don't + +193 +00:16:20,530 --> 00:16:26,070 +have room to consume the expenses so in in order + +194 +00:16:26,070 --> 00:16:30,270 +to to have space or to have a room to generate or + +195 +00:16:30,270 --> 00:16:35,470 +to cover our expenses this rate should be high and + +196 +00:16:35,470 --> 00:16:39,970 +just think of it if you generate here 40 percent + +197 +00:16:39,970 --> 00:16:43,530 +let's see 40 percent it means you have more room + +198 +00:16:43,530 --> 00:16:48,700 +to have more expensesto cover expenses and you + +199 +00:16:48,700 --> 00:16:52,060 +have the rest but if you have a very narrow space + +200 +00:16:52,060 --> 00:16:57,920 +or very narrow room if we have 10% so we may + +201 +00:16:57,920 --> 00:17:01,760 +challenge problems so this is the idea of + +202 +00:17:01,760 --> 00:17:07,940 +understanding the first part of of the income + +203 +00:17:07,940 --> 00:17:11,620 +statement which is the most important one because + +204 +00:17:11,620 --> 00:17:15,300 +it holds the higher expenses expensive comparing + +205 +00:17:15,300 --> 00:17:16,160 +with other expenses + +206 +00:17:19,180 --> 00:17:30,220 +لنعود إلى ال .. ال .. المثال فالـ + +207 +00:17:30,220 --> 00:17:34,720 +marketing department يجب أن يعمل صعبًا لإيجاد أكتر + +208 +00:17:34,720 --> 00:17:41,620 +شركات و لإنقاذ قيمة الشركات على مستوى أقل لإنقاذ + +209 +00:17:41,620 --> 00:17:44,940 +أكتر شركات، حسنا؟ + +210 +00:17:47,850 --> 00:17:56,270 +Okay and let's see Go + +211 +00:17:56,270 --> 00:18:05,910 +back to the So + +212 +00:18:05,910 --> 00:18:09,050 +interpreting the profitability you look at these + +213 +00:18:09,050 --> 00:18:12,770 +four main accounts these profit margins, gross + +214 +00:18:12,770 --> 00:18:13,450 +profit margin + +215 +00:18:16,500 --> 00:18:21,940 +يجب أن يكونوا مراقبينه جيدا ومقارنة بالسنوات + +216 +00:18:21,940 --> 00:18:26,340 +السابقة ومنافسة شركات محافظة والـ + +217 +00:18:26,340 --> 00:18:29,720 +GAAP والتعامل مع التعامل مع التعامل مع التعامل مع + +218 +00:18:29,720 --> 00:18:30,800 +التعامل مع التعامل مع التعامل مع التعامل مع + +219 +00:18:30,800 --> 00:18:32,540 +التعامل مع التعامل مع التعامل مع التعامل مع + +220 +00:18:32,540 --> 00:18:33,200 +التعامل مع التعامل مع التعامل مع التعامل مع + +221 +00:18:33,200 --> 00:18:34,260 +التعامل مع التعامل مع التعامل مع التعامل مع + +222 +00:18:34,260 --> 00:18:36,200 +التعامل مع التعامل مع التعامل مع التعامل مع + +223 +00:18:36,200 --> 00:18:44,760 +التعامل مع التعامل مع التعاملوالدفعات المقبلة + +224 +00:18:44,760 --> 00:18:49,160 +تعتمد عليها ويعاملينها يهتمون بها هذا يعني أن + +225 +00:18:49,160 --> 00:18:53,760 +الرئيسين يبحثون + +226 +00:18:53,760 --> 00:19:01,680 +بطريقة حسنة عن أهمية الوصول للمقالات لأنها مرتبطة + +227 +00:19:01,680 --> 00:19:07,920 +بالدفعات المقبلة وللدفعات طويلة وكذلك في تحسين + +228 +00:19:07,920 --> 00:19:12,120 +قيمة الشركةدعونا نعود إلى الانتباه لـ + +229 +00:19:12,120 --> 00:19:16,300 +Profitability، نعم، هنا الـ Gross Profit Margin + +230 +00:19:16,300 --> 00:19:20,800 +كما أشرحت، الـ Gross Profit مقاطعه من الأسهم، لذا + +231 +00:19:20,800 --> 00:19:30,140 +نحن لدينا 25% أشرح هذا، 1 دولار يجري 25 سنة و الـ + +232 +00:19:30,140 --> 00:19:37,480 +Markup هو 75% ال Markup هو مكمل، لذا الـ 75% يعني + +233 +00:19:38,400 --> 00:19:43,260 +واحد دولار مستثمر في هذا الشركة أسعار 75 سنة + +234 +00:19:43,260 --> 00:19:47,000 +كسلزاة + +235 +00:19:47,000 --> 00:19:53,400 +أسعار أسعار أسعار أسعار أسعار أسعار قيمة تعمل تعمل + +236 +00:19:53,400 --> 00:19:59,600 +تعمل تعمل تعمل تعمل تعمل تعمل تعمل تعمل تعمل تعمل + +237 +00:19:59,600 --> 00:20:04,790 +تعمل تعمل تعمل تعمل تعملثم 382 مليون مقارنة ب2000 + +238 +00:20:04,790 --> 00:20:13,170 +مليون وهذا 14% إذا تقارن 14% مع 25% ف25% هي حوالي + +239 +00:20:13,170 --> 00:20:23,970 +10% ف10% هي المساعدات العملية فالفرق بين 14% و25% + +240 +00:20:23,970 --> 00:20:33,980 +هو حوالي 10% فهذا 10% يمثل المساعدات العمليةوإذا + +241 +00:20:33,980 --> 00:20:41,160 +كنت تقارن هذا الـ 10% مع 25% فهو يعتبر نصف منه، + +242 +00:20:41,160 --> 00:20:48,240 +فهذا هو 10% مقارنه + +243 +00:20:48,240 --> 00:20:59,070 +مع 25% 10% هو الفرق بين هذا و25%هذا السبب فيه أنه + +244 +00:20:59,070 --> 00:21:03,010 +من المهم إن نجتمع أكتر شركات أو أكتر مقارنة نت + +245 +00:21:03,010 --> 00:21:09,970 +الروحية لكي نكون مرتاحين في العمل مقارنة نت + +246 +00:21:09,970 --> 00:21:13,830 +الروحية، مقارنة نت الروحية هي مقارنة نت الروحية أو + +247 +00:21:13,830 --> 00:21:13,930 +مقارنة نت الروحية مقارنة نت الروحية هي مقارنة نت + +248 +00:21:13,930 --> 00:21:15,370 +الروحية أو مقارنة نت الروحية مقارنة نت الروحية + +249 +00:21:15,370 --> 00:21:15,450 +مقارنة نت الروحية مقارنة نت الروحية مقارنة نت + +250 +00:21:15,450 --> 00:21:18,110 +الروحية مقارنة نت الروحية مقارنة نت الروحية مقارنة + +251 +00:21:18,110 --> 00:21:23,170 +نت الروحية مقارنة نت الروحية مق + +252 +00:21:30,700 --> 00:21:32,400 +على عدد المستخدمين المستخدمين المستخدمين + +253 +00:21:32,400 --> 00:21:36,540 +المستخدمين المستخدمين المستخدمين + +254 +00:21:36,540 --> 00:21:48,900 +المستخدمين + +255 +00:21:48,900 --> 00:21:51,400 +المستخدمين المستخدمين المستخدمين المستخدمين + +256 +00:21:51,400 --> 00:21:59,220 +المستخدم + +257 +00:22:02,950 --> 00:22:14,730 +7.58% لذلك ما تشاهده في هذه الفيجوريات الأولى 25% + +258 +00:22:14,730 --> 00:22:26,190 +والثاني 14.17% والثالث 7.58% + +259 +00:22:26,190 --> 00:22:30,450 +فماذا تشاهد؟ + +260 +00:22:30,450 --> 00:22:37,350 +مجموعات المال 25%مقارنة نت البروفيط هي 14% ثم نت + +261 +00:22:37,350 --> 00:22:46,930 +البروفيط هي 7.58% او 58% ما تلاحظه في هذه الحالة + +262 +00:22:46,930 --> 00:22:54,550 +نت البروفيط يتخلص؟ + +263 +00:22:54,550 --> 00:22:58,670 +نعم لماذا هذا؟ + +264 +00:23:04,200 --> 00:23:13,540 +بسبب الاسعار، بسبب الاسعار، نعم، لذا إذا تنظر إلى + +265 +00:23:13,540 --> 00:23:21,340 +7.15%، فهي نصف من 14%، وهذه .. الفرق بينها هي + +266 +00:23:21,340 --> 00:23:24,980 +حوالي 10%، لذلك هنا، الاسعار التي تعمل هنا تعتبر + +267 +00:23:24,980 --> 00:23:31,500 +حوالي 10% من الاسعار، والدفعات والدفعات تعتبر + +268 +00:23:31,500 --> 00:23:40,960 +حوالي 8% من الشركةلذلك دفعات ودفعات يأكلون حوال 8% + +269 +00:23:40,960 --> 00:23:49,860 +من الدفع اللي مرتفع أو اذا كنا نتكلم عن هذه الحاجة + +270 +00:23:49,860 --> 00:23:55,940 +الوظيفة الوظيفة تأكل حوال 10% من الدفع اللي مرتفع + +271 +00:23:55,940 --> 00:24:04,810 +لذا هذا مهم هذا شركة مستقلI mean it's fine to this + +272 +00:24:04,810 --> 00:24:08,490 +business but the problem in companies if we have a + +273 +00:24:08,490 --> 00:24:15,070 +problem like this if we have here 10% so we don't + +274 +00:24:15,070 --> 00:24:24,010 +have room 3% then we end with minus 7% in order to + +275 +00:24:24,010 --> 00:24:27,410 +secure ourselves in this area we have to maximize + +276 +00:24:27,410 --> 00:24:31,330 +this area in order to be in a safe place + +277 +00:24:36,840 --> 00:24:43,580 +try to do this check point 3.1 this + +278 +00:24:43,580 --> 00:24:47,260 +is about GAAP products under the GAAP you know + +279 +00:24:47,260 --> 00:24:52,980 +GAAP company GAAP use the following information to + +280 +00:24:52,980 --> 00:24:57,920 +construct an income statement okay for GAAP you + +281 +00:24:57,920 --> 00:25:05,180 +don't know GAAP GAAP what this for GAAP what this + +282 +00:25:05,180 --> 00:25:17,070 +forSports? No. No, this company. Gap? Yes. Yeah, + +283 +00:25:17,190 --> 00:25:21,090 +dresses. Yeah, Gap. It's .. it's a well-known + +284 +00:25:21,090 --> 00:25:28,060 +brand name. Okay? Gap.Okay so gallup old navy + +285 +00:25:28,060 --> 00:25:32,180 +banana rubric, pepper lime and atleta brand names + +286 +00:25:32,180 --> 00:25:36,380 +use the scrambled information .. scrambled .. + +287 +00:25:36,380 --> 00:25:40,280 +مبعترة مخربطة يعني حسابات مخربطة scrambled + +288 +00:25:40,280 --> 00:25:42,360 +information below to calculate the firm's gross + +289 +00:25:42,360 --> 00:25:46,420 +profits .. بدنا ال gross profits operating income + +290 +00:25:47,370 --> 00:25:51,350 +and net income for the year ended January 31st of + +291 +00:25:51,350 --> 00:25:55,650 +2009 then calculate the firms earning per share + +292 +00:25:55,650 --> 00:25:58,610 +and dividends per share بدنا نحسب ال dividends per + +293 +00:25:58,610 --> 00:26:01,410 +share هاي هما ال .. ال .. ال accounts اللي موجودون + +294 +00:26:01,410 --> 00:26:04,210 +عندنا طب ا follow the .. the rules that I + +295 +00:26:04,210 --> 00:26:07,890 +explained before gross profits then operating net + +296 +00:26:07,890 --> 00:26:11,630 +income then the pre-tax profit then the net income + +297 +00:26:11,630 --> 00:26:17,830 +okay this is the rulesوانتقل إلى استخدام استخدام + +298 +00:26:17,830 --> 00:26:18,950 +استخدام استخدام استخدام استخدام استخدام استخدام + +299 +00:26:18,950 --> 00:26:26,110 +استخدام استخدام استخدام استخدام استخدام استخدام + +300 +00:26:26,110 --> 00:26:27,710 +استخدام استخدام استخدام استخدام استخدام استخدام + +301 +00:26:27,710 --> 00:26:27,730 +استخدام استخدام استخدام استخدام استخدام استخدام + +302 +00:26:27,730 --> 00:26:30,290 +استخدام استخدام استخدام استخدام استخدام استخدام + +303 +00:26:30,290 --> 00:26:30,770 +استخدام استخدام استخدام استخدام استخدام استخدام + +304 +00:26:30,770 --> 00:26:30,850 +استخدام استخدام استخدام استخدام استخدام استخدام + +305 +00:26:30,850 --> 00:26:31,610 +استخدام استخدام استخدام استخدام استخدام استخدام + +306 +00:26:31,610 --> 00:26:43,130 +استخدام استخدام استخدام استخدام + +307 +00:26:43,130 --> 00:26:52,590 +استخاستخدام هذه المعلومات ثم ستحصل على تقنية + +308 +00:26:52,590 --> 00:26:58,590 +تقنيات تقنية + +309 +00:26:58,590 --> 00:27:02,810 +تقنية تقنية تقنية تقنية تقنية تقنية تقنية تقنية + +310 +00:27:02,810 --> 00:27:03,330 +تقنية تقنية تقنية تقنية تقنية تقنية تقنية تقنية + +311 +00:27:03,330 --> 00:27:03,350 +تقنية تقنية تقنية تقنية تقنية تقنية تقنية تقنية + +312 +00:27:03,350 --> 00:27:03,570 +تقنية تقنية تقنية تقنية تقنية تقنية تقنية تقنية + +313 +00:27:03,570 --> 00:27:10,090 +تقنية تقنية تقنية تقنية تقنية تقنية تقنية تقنية + +314 +00:27:10,090 --> 00:27:15,210 +تقن + +315 +00:27:16,110 --> 00:27:20,490 +التي تم إجراءها من المديرين، لذلك التجارب لديها + +316 +00:27:20,490 --> 00:27:27,070 +تأثير مباشر على عملية المشروع ولكن علينا أن ندفع + +317 +00:27:27,070 --> 00:27:33,450 +التجارب لأن الحكومات يجب أن تدفع عملياتها لتحميل + +318 +00:27:33,450 --> 00:27:37,330 +المشروع كوربيت + +319 +00:27:37,330 --> 00:27:42,670 +تاكس، تجارب التجارب مستخدمة باستخدام تجارب تجارب + +320 +00:27:42,670 --> 00:27:47,740 +مستخدمةand the tax rate on corporate income what + +321 +00:27:47,740 --> 00:27:50,400 +it means taxable income what it means taxable + +322 +00:27:50,400 --> 00:27:55,580 +income sorry + +323 +00:27:55,580 --> 00:28:02,240 +yes okay + +324 +00:28:02,240 --> 00:28:07,700 +what else taxable + +325 +00:28:07,700 --> 00:28:11,100 +income after + +326 +00:28:11,100 --> 00:28:19,040 +taxafter tax or before tax before tax before tax + +327 +00:28:19,040 --> 00:28:25,960 +earning before tax earning before tax yes or pre + +328 +00:28:25,960 --> 00:28:35,220 +-tax or EBT earning before tax okay so you are + +329 +00:28:35,220 --> 00:28:42,200 +right taxable income is the income subject to tax + +330 +00:28:44,450 --> 00:28:47,710 +this is fine what is the income that subject to + +331 +00:28:47,710 --> 00:28:52,850 +tax as we explained this is gross profits we don't + +332 +00:28:52,850 --> 00:29:00,050 +need this we have the gross profits then we have + +333 +00:29:00,050 --> 00:29:09,210 +operating profits we have then pre-tax this + +334 +00:29:09,210 --> 00:29:16,510 +is the taxable incomepre-tax or we can use the + +335 +00:29:16,510 --> 00:29:24,750 +term of evening before tax is + +336 +00:29:24,750 --> 00:29:32,250 +this taxable at a particular tax rate? this tax + +337 +00:29:32,250 --> 00:29:37,340 +rate differs from business to businessfor instance + +338 +00:29:37,340 --> 00:29:41,580 +smaller companies paying lower rates however the + +339 +00:29:41,580 --> 00:29:49,760 +larger companies paying higher rates okay now + +340 +00:29:49,760 --> 00:29:54,640 +so we know the tax rates we have a term tax rates + +341 +00:29:54,640 --> 00:29:59,940 +and we have term of marginalized tax or tax + +342 +00:29:59,940 --> 00:30:04,970 +marginsلنرى الاختلاف الرئيسي بين هذه الدفعات، انظر + +343 +00:30:04,970 --> 00:30:09,290 +إلى هذا البيانات هنا، تقسيم تجارب التجارب تقسيم + +344 +00:30:09,290 --> 00:30:13,970 +تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب + +345 +00:30:13,970 --> 00:30:14,030 +تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب + +346 +00:30:14,030 --> 00:30:14,050 +تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب + +347 +00:30:14,050 --> 00:30:14,650 +تجارب تجارب تجارب تجارب + +348 +00:30:29,430 --> 00:30:35,510 +So if we have sixty thousand dollar what is the + +349 +00:30:35,510 --> 00:30:43,990 +marginal tax? twenty five percent do some + +350 +00:30:43,990 --> 00:30:47,250 +calculations how much we should pay to the + +351 +00:30:47,250 --> 00:30:52,710 +government? just sixty thousand dollar how much it + +352 +00:30:52,710 --> 00:30:57,330 +means sixty thousand times twenty five percent + +353 +00:30:57,330 --> 00:31:07,980 +this is what you mean?Okay ten thousand okay + +354 +00:31:07,980 --> 00:31:12,040 +so ten thousand here what is the rest where is the + +355 +00:31:12,040 --> 00:31:16,180 +rest yes + +356 +00:31:16,180 --> 00:31:23,240 +fifty thousand percent times fifteen percent okay + +357 +00:31:23,240 --> 00:31:27,420 +so you sum this with this this is the tax to the + +358 +00:31:27,420 --> 00:31:29,200 +government is this right + +359 +00:31:32,010 --> 00:31:39,130 +نعم نفعلها حسنا هذا صحيح لذلك نحن ننظر إلى ال 50 + +360 +00:31:39,130 --> 00:31:47,010 +,000 ندفع 50,000 أولا و في 15% نحن نحصل على هذه + +361 +00:31:47,010 --> 00:31:52,910 +الدفعة ثم بقيةها 10,000 مرة في 25% نحن نحصل على + +362 +00:31:52,910 --> 00:31:56,910 +هذه الدفعة ثم مع هذا الجزء ومع هذا الجزء نحصل على + +363 +00:31:56,910 --> 00:32:03,910 +دفعة دفعة حسنا فهذا .. أسفة؟60 ألف عشرة تلاف عشرة + +364 +00:32:03,910 --> 00:32:07,990 +تلاف، هلا بناخد ال 50 ألف لها، ماشي 60 .. عندنا 60 + +365 +00:32:07,990 --> 00:32:13,350 +ألف في ال income أول واحدة كم هتاخد منها؟ 50 ألف، + +366 +00:32:13,350 --> 00:32:18,570 +نضربها في ال 15%، خلصنا، بزيد كم؟ عشر تلاف، نضربها + +367 +00:32:18,570 --> 00:32:23,430 +في ال .. في ال 25%، that's it خليني أخد مثال آخر + +368 +00:32:30,930 --> 00:32:36,810 +لو كان عندى مئة ألف the + +369 +00:32:36,810 --> 00:32:45,170 +taxable income is one hundred thousand if we + +370 +00:32:45,170 --> 00:32:49,010 +have one hundred thousand what is the tax? + +371 +00:32:52,850 --> 00:32:54,170 +what we can do then? + +372 +00:32:58,610 --> 00:33:03,730 +من أول الشهرة؟ Yes. من أول الشهرة؟ Yes. من أول + +373 +00:33:03,730 --> 00:33:05,230 +الشهرة؟ Yes. من أول الشهرة؟ Yes. من أول الشهرة؟ + +374 +00:33:05,230 --> 00:33:06,510 +Yes. من أول الشهرة؟ Yes. من أول الشهرة؟ Yes. من + +375 +00:33:06,510 --> 00:33:07,110 +أول الشهرة؟ Yes. من أول الشهرة؟ Yes. من أول + +376 +00:33:07,110 --> 00:33:07,370 +الشهرة؟ Yes. من أول الشهرة؟ Yes. من أول الشهرة؟ + +377 +00:33:07,370 --> 00:33:07,650 +Yes. من أول الشهرة؟ Yes. من أول الشهرة؟ Yes. من + +378 +00:33:07,650 --> 00:33:08,630 +Yes. من أول الشهرة؟ Yes. من أول الشهرة؟ Yes. من + +379 +00:33:08,630 --> 00:33:17,990 +أول الشهرة؟ Yes. من أول الشهرة؟ Yes. من أول + +380 +00:33:17,990 --> 00:33:22,630 +الشهرة؟ + +381 +00:33:22,630 --> 00:33:27,350 +Yes. من أول الشهرة؟ + +382 +00:33:27,350 --> 00:33:35,980 +Yesthirty four percent and you sum this okay so + +383 +00:33:35,980 --> 00:33:45,240 +this is the taxes yes okay خلّيني أعيدك أول مرة + +384 +00:33:45,240 --> 00:33:48,780 +احنا إذا معاك انت خمسين ألف إذا أربحت خمسين ألف + +385 +00:33:48,780 --> 00:33:52,940 +بدك تدفع خمس عشر في الدمية لهم إذا أربحت من خمسين + +386 +00:33:52,940 --> 00:33:55,700 +ألف لخمس وسبعين ألف يعني كده احنا أضفناها خمس + +387 +00:33:55,700 --> 00:34:01,610 +وعشرين ألفتمام؟ هنربح 25% طيب الـ 25 ألف التانية + +388 +00:34:01,610 --> 00:34:06,490 +التالتة هنربحها هندفع عليها 34% خلينا step by step + +389 +00:34:06,490 --> 00:34:11,410 +أول 50 ألف دفعنا عليهم 15% ربحنا احنا 100 ألف + +390 +00:34:11,410 --> 00:34:18,170 +خلصنا نيجي هالي قداش ندفع عليها 25 ألف الذئب + +391 +00:34:18,170 --> 00:34:22,110 +التانية هندفع عليها 25% هاي ال 25 ألف التانية + +392 +00:34:22,110 --> 00:34:28,810 +ضربناها 25% طيب في 25 ألف البعديهااربعة و تلاتين + +393 +00:34:28,810 --> 00:34:33,010 +فمية اربعة و تلاتين فمية okay so تتفقق و بنجمع هذا + +394 +00:34:33,010 --> 00:34:37,070 +ال tax اللى هندفعه لمنى لل governments this tax to + +395 +00:34:37,070 --> 00:34:44,390 +be paid to the governments في + +396 +00:34:44,390 --> 00:34:47,490 +هذا + +397 +00:34:47,490 --> 00:34:55,950 +ال range هنيجي هتكون اربعة و تلاتين فمية هدول + +398 +00:34:55,950 --> 00:35:00,670 +هندفعه من الحكومةدريبة على الجزء هذا و دريبة على + +399 +00:35:00,670 --> 00:35:05,370 +الجزء هذا و دريبة على الجزء هذا و + +400 +00:35:05,370 --> 00:35:07,510 +احنا دفعنا دريبة على الجزء كله، احنا دفعين، بس + +401 +00:35:07,510 --> 00:35:12,470 +الجزء .. بنفعش نروح .. نروح ندفع دريبة ل .. + +402 +00:35:12,470 --> 00:35:15,470 +الشركات الصغيرة تدفع نفس الدريبة للشركات الكبيرة + +403 +00:35:15,470 --> 00:35:18,730 +يعني الشركات الصغيرة تدفع نفس دريبة الشركات + +404 +00:35:18,730 --> 00:35:24,570 +الصغيرة فإيش بنسوي؟ كل ما احنا بزيد ال income كل + +405 +00:35:24,570 --> 00:35:28,770 +ما الدريبة هتزيدلو ع كلامك بده نمشي إيش بنسوي؟ لو + +406 +00:35:28,770 --> 00:35:32,910 +أنا 100 ألف هطبقها على 15% كل الشركات بتدفع نفس ال + +407 +00:35:32,910 --> 00:35:36,290 +rate فكل ما بزيد ال income تبعيه كل ما أنا برفع + +408 +00:35:36,290 --> 00:35:43,190 +معدل الضريبة هاي + +409 +00:35:43,190 --> 00:35:48,860 +100 ألف أه يعني جزك نطبقها هانلأ مش هيك بتصير لإن + +410 +00:35:48,860 --> 00:35:53,080 +هاد الدريبة مدفوعة بس على 25 ألف هان إيش معناه + +411 +00:35:53,080 --> 00:35:57,180 +الدريبة is .. إيش معناه marginal .. marginal tax + +412 +00:35:57,180 --> 00:36:02,400 +is the additional one dollar to be taxed يعني إذا + +413 +00:36:02,400 --> 00:36:04,500 +احنا ربحنا one dollar زيادة كده إيش هناخد عليه + +414 +00:36:04,500 --> 00:36:08,820 +دريبة مش as a sum ال 100 ألف ناخدها زي ما هي و + +415 +00:36:08,820 --> 00:36:12,120 +نضربها في الرقم يعنيش نضربها هان طب إحنا إجينا ال + +416 +00:36:12,120 --> 00:36:20,500 +100 ألف ع كلامك وجعت هان صح؟this is unfair هيتلع + +417 +00:36:20,500 --> 00:36:25,100 +عليها 100 ألف في 34% كتير فإيش بنسول okay كم هذه + +418 +00:36:25,100 --> 00:36:28,200 +نصيبة؟ خمسين ألف okay كم هذه نصيبة؟ خمسة و عشرين + +419 +00:36:28,200 --> 00:36:31,400 +ألف okay هى خمسة و سبعين كدهش ضال؟ خمسة و عشرين + +420 +00:36:31,400 --> 00:36:36,880 +ألف كل واحدة مضربها في اللقبالة هذا بيسموه ال + +421 +00:36:36,880 --> 00:36:37,960 +marginal tax rate + +422 +00:36:45,390 --> 00:36:49,070 +Okay so corporate tax rates the table reveals that + +423 +00:36:49,070 --> 00:36:54,910 +the following tax rate range from 15% to 39% يعني + +424 +00:36:54,910 --> 00:37:00,270 +15% 39% من أعلى إشي لأقل إشي بتلاحظوا the tax rate + +425 +00:37:00,270 --> 00:37:03,190 +is increased till here this is the peak then it's + +426 +00:37:03,190 --> 00:37:09,010 +go down then okay yes tax rates are progressive + +427 +00:37:10,400 --> 00:37:13,860 +larger corporations with higher profits will tend + +428 +00:37:13,860 --> 00:37:16,560 +to pay more taxes compared with the smaller firms + +429 +00:37:16,560 --> 00:37:20,260 +note in addition to federal tax a firm may face + +430 +00:37:20,260 --> 00:37:25,200 +state and city taxes يعني كمان بدفعوا ضريبة ال + +431 +00:37:25,200 --> 00:37:30,340 +city taxes marginal and average tax rates while + +432 +00:37:30,340 --> 00:37:33,080 +analyzing the tax consequences of a new business + +433 +00:37:33,080 --> 00:37:35,560 +venture the appropriate tax rate is the marginal + +434 +00:37:35,560 --> 00:37:41,260 +tax rate اللي هو ال marginalحسب قداش احنا بناخد + +435 +00:37:41,260 --> 00:37:45,720 +income مش مرة واحدة نضرب الطريقة marginal tax rate + +436 +00:37:45,720 --> 00:37:48,460 +is the tax rate that company will pay on its next + +437 +00:37:48,460 --> 00:37:52,220 +dollar as I explained on its next dollar of the + +438 +00:37:52,220 --> 00:37:55,620 +taxable income to the next dollar not as a lump + +439 +00:37:55,620 --> 00:38:00,280 +sum average tax rate is the total taxes paid + +440 +00:38:00,280 --> 00:38:06,060 +dividend divided by the taxable income average tax + +441 +00:38:06,060 --> 00:38:11,540 +ratesبعدين بدنا نعرف جداش ال average tax rate إيش + +442 +00:38:11,540 --> 00:38:16,740 +بنسوي؟ بنطلع ال total هذا و بنجسمه على ال 100000 + +443 +00:38:16,740 --> 00:38:20,180 +بتطلع ال average tax rate بتتوقعوا على جداش مكون + +444 +00:38:20,180 --> 00:38:24,660 +ال average tax rate في الحالة هذه؟ يعني اتوقعوا + +445 +00:38:24,660 --> 00:38:32,680 +ليه جداش؟ تقريبا 22% لكن لو احنا ضلبناها ب 34% + +446 +00:38:32,680 --> 00:38:37,070 +هنتفع تلاها 34% فاحنا هذا is fairيعني ال average + +447 +00:38:37,070 --> 00:38:42,630 +tax rate is fair in this case okay + +448 +00:38:42,630 --> 00:38:48,050 +and this is the explanation of the tax rate + +449 +00:38:48,050 --> 00:38:52,170 +taxable income fifty thousands لو احنا رجعنا ل + +450 +00:38:52,170 --> 00:38:56,070 +this which is similar to this fifty thousand + +451 +00:38:56,070 --> 00:39:01,180 +seventy five نرجع لهدولهي خمسين ألف طلعوها + +452 +00:39:01,180 --> 00:39:05,320 +accumulative fifty thousands دفعناهم بعدين هنضيف + +453 +00:39:05,320 --> 00:39:11,540 +ال 25 ألف هيصير كام؟ هنضيف ال 25 ألف هيصير 100 ألف + +454 +00:39:11,540 --> 00:39:16,920 +okayfifty .. fifteen percent, twenty-five percent, + +455 +00:39:17,020 --> 00:39:20,100 +thirty-four percent قيمة ال tax سبعة تلاف و خمسمية + +456 +00:39:20,100 --> 00:39:23,740 +في الخمسين ألف ستلاف و متان و خمسين في الخمسة و + +457 +00:39:23,740 --> 00:39:26,240 +عشرين في المية في الخمسة و عشرين ألف تمام تلاف و + +458 +00:39:26,240 --> 00:39:29,700 +خمسمية في الاربعة و تلاتين و خمسين و عشرين بتلع + +459 +00:39:29,700 --> 00:39:34,520 +عادل أرقام و double check اه try to double check + +460 +00:39:34,520 --> 00:39:34,820 +this + +461 +00:39:39,260 --> 00:39:43,440 +Average tax rates as we see here the total tax + +462 +00:39:43,440 --> 00:39:53,540 +اللي هندفعه 22250 okay 2250 divided by 100000$ so + +463 +00:39:53,540 --> 00:40:03,780 +the average tax is 22.25% okay andعشان تاكس ريت 39 + +464 +00:40:03,780 --> 00:40:07,520 +% كما يجب على الشركة أن تدفع 39% من دولارها الاخر + +465 +00:40:07,520 --> 00:40:14,660 +لذلك الآن لدولار الاخر إذا كنت تدخل هنا إذا كانت + +466 +00:40:14,660 --> 00:40:20,660 +الشركة تدفع 100 ألف أكتر من 1 دولار الشركة ستدفع + +467 +00:40:20,660 --> 00:40:28,000 +39% لذلك الدولار الاخر وعادية تاكس ريت هي كما نقل + +468 +00:40:29,190 --> 00:40:32,130 +على دولار التجارب التالف من دولار تجارب تجارب + +469 +00:40:32,130 --> 00:40:34,650 +تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب + +470 +00:40:34,650 --> 00:40:35,430 +تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب + +471 +00:40:35,430 --> 00:40:37,050 +تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب + +472 +00:40:37,050 --> 00:40:38,070 +تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب + +473 +00:40:38,070 --> 00:40:38,530 +تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب + +474 +00:40:53,070 --> 00:40:57,450 +and the taxable dividends okay next meeting please + +475 +00:40:57,450 --> 00:41:02,530 +just read the previous chapters and inshallah + +476 +00:41:02,530 --> 00:41:05,190 +we'll talk about the dividends and talk about the + +477 +00:41:05,190 --> 00:41:10,250 +balance sheets and do the checkpoints اه do the + +478 +00:41:10,250 --> 00:41:14,250 +checkpoints a checkpoint is 3.1 تحاولوا تشتغلوها + +479 +00:41:14,250 --> 00:41:17,290 +وإذا أنتم فيه عندكم مشكلة بس تتعجبونا فيها okay + +480 +00:41:17,290 --> 00:41:18,050 +الله يعطيكوا العافية + diff --git a/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/BQGlVtONd7I_raw.json b/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/BQGlVtONd7I_raw.json new file mode 100644 index 0000000000000000000000000000000000000000..36a3d04b8394b3601b1a3ed2ac9cae4ecc7fc14b --- /dev/null +++ b/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/BQGlVtONd7I_raw.json @@ -0,0 +1 @@ +{"segments": [{"id": 1, "seek": 4692, "start": 19.48, "end": 46.92, "text": "لقاء الماضي كنا نحكي بال .. بال income statements و ال .. ال components of the income statements خلينا بس أنه أنا أذكركم just remind 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No. No, this company. Gap? Yes. Yeah, dresses. Yeah, Gap. It's .. it's a well-known brand name. Okay? 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"end": 1543.72, "word": " ال", "probability": 0.82763671875}, {"start": 1543.72, "end": 1543.98, "word": " gross", "probability": 0.85546875}, {"start": 1543.98, "end": 1544.48, "word": " profits", "probability": 0.48291015625}, {"start": 1544.48, "end": 1545.9, "word": " operating", "probability": 0.763671875}, {"start": 1545.9, "end": 1546.42, "word": " income", "probability": 0.95751953125}], "temperature": 1.0}, {"id": 57, "seek": 157379, "start": 1547.37, "end": 1573.79, "text": "and net income for the year ended January 31st of 2009 then calculate the firms earning per share and dividends per share بدنا نحسب ال dividends per share هاي هما ال .. ال .. ال accounts اللي موجودون عندنا طب ا follow the .. the rules that I explained before gross profits then operating net income then the pre-tax profit then the net income okay this is the rules", "tokens": [474, 2533, 5742, 337, 264, 1064, 4590, 7061, 10353, 372, 295, 11453, 550, 8873, 264, 18055, 12353, 680, 2073, 293, 39675, 680, 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as a sum ال 100 ألف ناخدها زي ما هي و نضربها في الرقم يعنيش نضربها هان طب إحنا إجينا ال 100 ألف ع كلامك وجعت هان صح؟", "tokens": [1211, 10721, 37893, 39896, 4117, 39894, 9381, 13546, 5296, 28814, 1863, 8032, 18513, 32748, 16572, 49401, 3714, 3215, 5172, 2407, 27884, 4724, 3794, 15844, 3552, 5551, 46538, 8032, 7649, 11933, 1829, 8592, 20449, 8315, 3224, 32748, 16572, 49401, 307, 4386, 11933, 1829, 8592, 20449, 8315, 3224, 16885, 4386, 16885, 3366, 307, 264, 4497, 472, 7241, 281, 312, 3366, 292, 37495, 22653, 11933, 15730, 1975, 5016, 8315, 12602, 49628, 8315, 472, 7241, 30767, 1829, 18513, 3660, 9122, 3215, 3224, 11933, 1829, 8592, 8032, 1863, 47283, 3215, 47356, 11778, 16572, 49401, 37893, 382, 257, 2408, 2423, 2319, 5551, 46538, 8717, 47283, 3215, 11296, 30767, 1829, 19446, 39896, 4032, 8717, 11242, 25513, 11296, 8978, 34892, 4587, 2304, 37495, 22653, 8592, 8717, 11242, 25513, 11296, 8032, 7649, 23032, 3555, 11933, 5016, 8315, 11933, 7435, 1829, 8315, 2423, 2319, 5551, 46538, 6225, 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"probability": 0.89404296875}, {"start": 2223.35, "end": 2223.63, "word": " down", "probability": 0.869140625}, {"start": 2223.63, "end": 2223.87, "word": " then", "probability": 0.47412109375}, {"start": 2223.87, "end": 2225.23, "word": " okay", "probability": 0.80712890625}, {"start": 2225.23, "end": 2226.59, "word": " yes", "probability": 0.8564453125}, {"start": 2226.59, "end": 2227.71, "word": " tax", "probability": 0.73046875}, {"start": 2227.71, "end": 2228.01, "word": " rates", "probability": 0.9326171875}, {"start": 2228.01, "end": 2228.39, "word": " are", "probability": 0.9638671875}, {"start": 2228.39, "end": 2229.01, "word": " progressive", "probability": 0.87255859375}], "temperature": 1.0}, {"id": 81, "seek": 225788, "start": 2230.4, "end": 2257.88, "text": "larger corporations with higher profits will tend to pay more taxes compared with the smaller firms note in addition to federal tax a firm may face state and city taxes يعني كمان بدفعوا ضريبة ال city taxes marginal and average tax rates while analyzing the tax consequences of a new business venture the appropriate tax rate is the marginal tax rate اللي هو ال marginal", "tokens": [2200, 1321, 17676, 365, 2946, 17982, 486, 3928, 281, 1689, 544, 10041, 5347, 365, 264, 4356, 18055, 3637, 294, 4500, 281, 6019, 3366, 257, 6174, 815, 1851, 1785, 293, 2307, 10041, 37495, 22653, 9122, 2304, 7649, 47525, 5172, 3615, 14407, 48812, 16572, 49401, 2423, 2307, 10041, 16885, 293, 4274, 3366, 6846, 1339, 23663, 264, 3366, 10098, 295, 257, 777, 1606, 18474, 264, 6854, 3366, 3314, 307, 264, 16885, 3366, 3314, 13672, 1829, 31439, 2423, 16885], "avg_logprob": -0.18143502897337863, "compression_ratio": 1.5856573705179282, "no_speech_prob": 1.1920928955078125e-07, "words": [{"start": 2230.4, "end": 2230.96, "word": "larger", "probability": 0.7249755859375}, {"start": 2230.96, "end": 2231.54, "word": " corporations", "probability": 0.60791015625}, {"start": 2231.54, "end": 2231.86, "word": " with", "probability": 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2253.08, "end": 2253.4, "word": " venture", "probability": 0.93359375}, {"start": 2253.4, "end": 2253.66, "word": " the", "probability": 0.69140625}, {"start": 2253.66, "end": 2254.16, "word": " appropriate", "probability": 0.76806640625}, {"start": 2254.16, "end": 2254.58, "word": " tax", "probability": 0.94580078125}, {"start": 2254.58, "end": 2254.84, "word": " rate", "probability": 0.96240234375}, {"start": 2254.84, "end": 2255.06, "word": " is", "probability": 0.96826171875}, {"start": 2255.06, "end": 2255.24, "word": " the", "probability": 0.8828125}, {"start": 2255.24, "end": 2255.56, "word": " marginal", "probability": 0.91845703125}, {"start": 2255.56, "end": 2255.9, "word": " tax", "probability": 0.93896484375}, {"start": 2255.9, "end": 2256.36, "word": " rate", "probability": 0.89013671875}, {"start": 2256.36, "end": 2257.42, "word": " اللي", "probability": 0.978759765625}, {"start": 2257.42, "end": 2257.5, "word": " هو", "probability": 0.98876953125}, {"start": 2257.5, 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الأسماء الأسماء + +23 +00:01:49,550 --> 00:01:50,870 +الأسماء الأسماء الأسماء الأسماء الأسماء الأسماء + +24 +00:01:50,870 --> 00:01:53,850 +الأسماء الأسماء الأسماء الأسماء الأسماء الأسماء + +25 +00:01:53,850 --> 00:01:56,310 +الأسماء الأسماء الأسماء الأسماء الأسماء الأسماء + +26 +00:01:56,310 --> 00:01:59,530 +الأسماء الأسماء الأسماء الأسماء الأسماء الأسماء + +27 +00:01:59,530 --> 00:02:10,970 +الأسماء الأسماء الأسماء الأسماء الأسماء + +28 +00:02:11,390 --> 00:02:15,570 +عن كم وقت تستخدمها لتحويل المصادر المستقبلية إلى + +29 +00:02:15,570 --> 00:02:20,970 +المال بمعنى كم مرة نستطيع تحويل المصادر + +30 +00:02:20,970 --> 00:02:25,670 +المستقبلية إلى المال في عام، والشيء نفسه عندما + +31 +00:02:25,670 --> 00:02:29,610 +نتحدث عن المصادر كم وقت يستخدمها لتحويل المصادر + +32 +00:02:29,610 --> 00:02:31,810 +إلى المال، هذا المهم + +33 +00:02:36,680 --> 00:02:40,440 +الحصة المستخدمة مقومة بمقارنة عامة، تجارب التجارب + +34 +00:02:40,440 --> 00:02:44,620 +كم ساعة تستخدمها لتحويل الحصة المستخدمة إلى المال + +35 +00:02:44,620 --> 00:02:48,240 +نقل الحصة المستخدمة للحصة المستخدمة للحصة + +36 +00:02:48,240 --> 00:02:48,380 +المستخدمة للحصة المستخدمة للحصة المستخدمة للحصة + +37 +00:02:48,380 --> 00:02:52,440 +المستخدمة للحصة المستخدمة للحصة المستخدمة للحصة + +38 +00:02:52,440 --> 00:02:56,420 +المستخدمة للحصة المستخدمة للحصة المستخدمة للحصة + +39 +00:02:56,420 --> 00:02:56,640 +المستخدمة للحصة المستخدمة للحصة المستخدمة للحصة + +40 +00:02:56,640 --> 00:02:59,220 +المستخدمة للحصة المستخدمة للحصة المستخدمة للحصة + +41 +00:02:59,220 --> 00:03:04,260 +المستخدمة للحصة + +42 +00:03:08,390 --> 00:03:12,750 +لذلك إذا كان لدينا يومين أفضل من أن يكون لدينا يومين + +43 +00:03:12,750 --> 00:03:16,330 +أكبر، دعونا... على سبيل المثال إذا عمر التجارب + +44 +00:03:16,330 --> 00:03:20,230 +العادل عمر + +45 +00:03:20,230 --> 00:03:23,270 +التجارب عمر التجارب عمر تجارب عمر تجارب عمر تجارب + +46 +00:03:23,270 --> 00:03:25,110 +عمر تجارب عمر تجارب عمر تجارب عمر تجارب عمر تجارب + +47 +00:03:25,110 --> 00:03:27,230 +عمر تجارب عمر تجارب عمر تجارب عمر تجارب عمر تجارب + +48 +00:03:27,230 --> 00:03:29,230 +عمر تجارب عمر تجارب عمر تجارب عمر تجارب عمر تجارب + +49 +00:03:29,230 --> 00:03:32,910 +عمر تجارب عمر تجارب عمر + +50 +00:03:32,910 --> 00:03:37,390 +تجارب عمر + +51 +00:03:37,390 --> 00:03:37,470 +تج + +52 +00:03:40,630 --> 00:03:46,270 +collecting periods which is indicate company A may + +53 +00:03:46,270 --> 00:03:53,470 +have more liquidity than company B, okay, some in + +54 +00:03:53,470 --> 00:03:58,050 +some cases people calculate the account receivable + +55 +00:03:58,050 --> 00:04:02,630 +by the account receivable turnover instead of + +56 +00:04:02,630 --> 00:04:05,250 +using average collection periods, they are using + +57 +00:04:05,250 --> 00:04:08,410 +account + +58 +00:04:08,410 --> 00:04:10,010 +receivable turnover + +59 +00:04:12,430 --> 00:04:15,230 +كيف يفعلون هذا هو أنهم يقومون بتقليل المستخدم + +60 +00:04:15,230 --> 00:04:20,250 +المستخدم المستخدم + +61 +00:04:20,250 --> 00:04:28,110 +المستخدم المستخدم المستخدم المستخدم المستخدم + +62 +00:04:28,110 --> 00:04:31,090 +المستخدم المستخدم المستخدم المستخدم المستخدم + +63 +00:04:31,090 --> 00:04:34,670 +المستخدم المستخدم المستخدم المستخدم المستخدم + +64 +00:04:34,670 --> 00:04:36,750 +المستخدم المستخدم المستخدم المستخدم المستخدم + +65 +00:04:36,750 --> 00:04:37,070 +المستخدم المستخدم المستخدم المستخدم المستخدم + +66 +00:04:37,070 --> 00:04:41,650 +المستخدم المستخدم المستخدم المستخدم المستخدم + +67 +00:04:41,650 --> 00:04:41,770 +المستخدم المستخدم المستخدم المستخدم المستخدم + +68 +00:04:41,770 --> 00:04:44,150 +المستخدم المستخدم المستخدم،النتائج ستكون في + +69 +00:04:44,150 --> 00:04:49,850 +الوقت المناسب لذلك باعتبار هذا الواقع المستقبلي كم + +70 +00:04:49,850 --> 00:04:58,890 +مرة تحول الشركة الواقع المستقبلي إلى مال، نتوقع + +71 +00:04:58,890 --> 00:05:02,750 +أن الشركة تكون لديها زيارة أكثر من الشركة الأخرى + +72 +00:05:02,750 --> 00:05:07,110 +على سبيل المثال إذا ما زالت لدينا شركة A وشركة B + +73 +00:05:07,110 --> 00:05:15,990 +إذا كانت شركة A لديها ثلاث مرات وشركة + +74 +00:05:15,990 --> 00:05:28,160 +B لديها 15 مرة، يعني أن هذا It takes 13 times to + +75 +00:05:28,160 --> 00:05:31,360 +convert asset into cash, so if you convert this + +76 +00:05:31,360 --> 00:05:36,800 +into days you just need to do 360 divided by 30 + +77 +00:05:36,800 --> 00:05:40,500 +times, you get the number of days, you can do it in + +78 +00:05:40,500 --> 00:05:44,580 +different ways لو + +79 +00:05:44,580 --> 00:05:47,260 +this is 30 times a year + +80 +00:05:50,260 --> 00:05:55,680 +تقوم بتحويل المصادر المستقبلية إلى المال 30 مرة + +81 +00:05:55,680 --> 00:06:04,460 +في السنة، الآن أنا أسألك ماذا؟ 30 أو 15؟ 30 مرة هو + +82 +00:06:04,460 --> 00:06:08,980 +أكثر من 15 مرة، حسنًا، + +83 +00:06:08,980 --> 00:06:12,420 +هذا + +84 +00:06:12,420 --> 00:06:16,040 +هو طريقة تخطيط مصادر المال اليومي 2500 مليون مليون + +85 +00:06:16,040 --> 00:06:19,070 +مليون مليون مليون مليون مليون مليون مليونaccount + +86 +00:06:19,070 --> 00:06:22,110 +receivable divided by credits daily credit sales + +87 +00:06:22,110 --> 00:06:25,270 +so this is the account receivable divided by daily + +88 +00:06:25,270 --> 00:06:30,430 +credit sales, you have 20 days, so it takes 20 days + +89 +00:06:30,430 --> 00:06:34,950 +to convert the account receivable into cash, you + +90 +00:06:34,950 --> 00:06:38,190 +can compare this with the peer group or with the + +91 +00:06:38,190 --> 00:06:45,390 +industrial level and then judge on this result، وهذا + +92 +00:06:45,390 --> 00:06:48,190 +الـ account receivable turned over، وهذا مخصص على + +93 +00:06:48,190 --> 00:06:54,490 +الوقت، وهذا مخصص على عدد الأيام، وهذا مخصص على الوقت + +94 +00:06:54,490 --> 00:06:59,550 +ومجدداً يعني شركات دفعات عامة مختلفة من الـ + +95 +00:06:59,550 --> 00:07:07,650 +account receivable ونتيجة في الوقت 17 مرة، تأخذ كل + +96 +00:07:07,650 --> 00:07:13,950 +ال...ال...ال account receivable هو مقفل 17 مرة + +97 +00:07:13,950 --> 00:07:24,210 +أو مقفل 17 مرة في العمل في العمل + +98 +00:07:24,210 --> 00:07:24,650 +في العمل في العمل في العمل في العمل في العمل في + +99 +00:07:24,650 --> 00:07:24,890 +في العمل في العمل في العمل في العمل في العمل في + +100 +00:07:24,890 --> 00:07:25,050 +في العمل في العمل في العمل في العمل في العمل في + +101 +00:07:25,050 --> 00:07:25,130 +العمل في العمل في العمل في العمل في العمل في العمل + +102 +00:07:25,130 --> 00:07:25,190 +في العمل في العمل في العمل في العمل في العمل في + +103 +00:07:25,190 --> 00:07:27,050 +في العمل في العمل في العمل في العمل في العمل في + +104 +00:07:27,050 --> 00:07:39,870 +العمل في العمل في العمل في العمل في العمل في العمل + +105 +00:07:39,870 --> 00:07:48,500 +في، ننتقل لتعريف المال ومقالات شركة Aswell لديك + +106 +00:07:48,500 --> 00:07:58,520 +قيمة الأسعار 1980 مقالة 229 مقالة لديك 8.63 مرة + +107 +00:07:58,520 --> 00:08:04,640 +هذا يعني أننا عملنا تغيير المصادر إلى المال 8.63 + +108 +00:08:04,640 --> 00:08:09,880 +مرة في السنة، إذا أردت تغييرها إلى أيام فتفعل 360 + +109 +00:08:09,880 --> 00:08:22,360 +أو 65 مرة، مع 8.63 تحصل على عدد الأيام ونتوقع + +110 +00:08:22,360 --> 00:08:27,600 +أن أعلى عدد الإنتاج الذي يتم تحويله يكون أفضل أو + +111 +00:08:27,600 --> 00:08:35,860 +يكون أفضل بالنسبة للعمل، في peer group peer group is + +112 +00:08:35,860 --> 00:08:39,160 +like you compare yourself with the industry or + +113 +00:08:39,160 --> 00:08:42,880 +with the competitors زي معظم؟ معظم؟ yes يعني احنا + +114 +00:08:42,880 --> 00:08:48,220 +مش بنحسبوش؟ no this is your competitors the peer + +115 +00:08:48,220 --> 00:08:52,480 +group is your competitors you comparing this 8.63 + +116 +00:08:52,480 --> 00:08:59,890 +for instance this 8.63 with the peer group، والـ + +117 +00:08:59,890 --> 00:09:04,970 +Inventory هي 8.63 مرة، وإذا كانت الـ peer group 9 + +118 +00:09:04,970 --> 00:09:09,910 +أو 11، فهذا يعني أننا لدينا مشاكل في الـ Inventory + +119 +00:09:09,910 --> 00:09:15,070 +لأن الـ peer group أعلى في الوقت الذي يقوم بتحويل + +120 +00:09:15,070 --> 00:09:21,210 +الـ Inventory إلى الـ Cash من شركة PassWell، سنعود + +121 +00:09:21,210 --> 00:09:27,310 +في التفاصيل عن الـ Inventory turnover عندما نتحدث + +122 +00:09:27,310 --> 00:09:33,750 +عن تسريح الأسعار أو عملية تسريح الأسعار بالنسبة + +123 +00:09:33,750 --> 00:09:42,150 + لعدد الأيام، كما فعلت 365×8.63 لذلك يحتاج إلى 42 + +124 +00:09:42,150 --> 00:09:45,870 +يومًا لتغيير الـ Inventory إلى الـ Cash، لذلك + +125 +00:09:45,870 --> 00:09:47,310 +السيكلة تتحرك مثل هذا + +126 +00:09:52,380 --> 00:09:59,060 +هذا هو الانفجار ثم + +127 +00:09:59,060 --> 00:10:05,260 +نقوم بتحويل الانفجار إلى السوق ثم السوق إلى المال + +128 +00:10:05,260 --> 00:10:08,960 +لذلك + +129 +00:10:08,960 --> 00:10:15,440 +يستغرق حوالي 42 يومًا لتحويل الانفجار إلى مال، وقت + +130 +00:10:15,440 --> 00:10:18,360 +هذا حوالي 42 يومًا + +131 +00:10:21,410 --> 00:10:28,790 +Okay, so around one month and a half for + +132 +00:10:28,790 --> 00:10:36,370 +the two days, Can + +133 +00:10:36,370 --> 00:10:40,450 +a firm have too much liquidity? Yes, is good for + +134 +00:10:40,450 --> 00:10:44,030 +business having too much liquidity? No, why not? + +135 +00:10:46,530 --> 00:10:49,270 +Yes, because they are missing the opportunity for + +136 +00:10:49,270 --> 00:10:55,080 +investment، السؤال هو إذا كان لديه الكثير من المال + +137 +00:10:55,080 --> 00:11:02,520 +جيد للعمل أم لا؟ لا، لماذا؟ لأنه لا يوجد فرصة + +138 +00:11:02,520 --> 00:11:07,740 +لـ investments، دعونا نذهب إلى المنتجات هذه + +139 +00:11:07,740 --> 00:11:17,620 +المنتجات تجمع مواقع Dell, Apple و HP، والثلاث شركات + +140 +00:11:17,620 --> 00:11:22,920 +تعمل في الكمبيوتر أو دعنا نقول البرنامج، الـhardware + +141 +00:11:22,920 --> 00:11:26,420 +لذلك + +142 +00:11:26,420 --> 00:11:31,500 +يو بوس طلب منك أن تنظر إلى ميزة ديلز لذلك يجب أن + +143 +00:11:31,500 --> 00:11:35,680 +ننظر إلى ميزة ديلز ونقوم بالتحقق من قدرتها على + +144 +00:11:35,680 --> 00:11:40,800 +وقتها باستخدام المعلومات التالية وسنقوم بتقارير + +145 +00:11:40,800 --> 00:11:47,780 +ديلز مع الشركات الأخرى، أبل وHP لذلك لديك هذه + +146 +00:11:47,780 --> 00:11:50,200 +الواقعات الحالية الواقعات المستحيلة من + +147 +00:11:50,200 --> 00:11:52,960 +المال الانفجارات الأسعار مستخدمات الأسعار + +148 +00:11:52,960 --> 00:11:54,740 +ومستخدمات الأسعار ومستخدمات الأسعار ومستخدمات + +149 +00:11:54,740 --> 00:11:54,900 +الأسعار ومستخدمات الأسعار ومستخدمات الأسعار + +150 +00:11:54,900 --> 00:11:54,920 +ومستخدمات الأسعار ومستخدمات الأسعار ومستخدمات + +151 +00:11:54,920 --> 00:11:55,060 +ومستخدمات الأسعار ومستخدمات الأسعار ومستخدمات + +152 +00:11:55,060 --> 00:12:03,800 +ومستخدمات الأسعار ومستخدمات + +153 +00:12:03,800 --> 00:12:08,700 +الأسعار + +154 +00:12:08,700 --> 00:12:13,760 +وم + +155 +00:12:14,590 --> 00:12:19,570 +بإمكاننا أن نقوم بهذا أن الديل يحتوي على عدد + +156 +00:12:19,570 --> 00:12:25,090 +عدد عدد عدد عدد عدد عدد + +157 +00:12:25,090 --> 00:12:25,430 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +158 +00:12:25,430 --> 00:12:25,710 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +159 +00:12:25,710 --> 00:12:25,770 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +160 +00:12:25,770 --> 00:12:26,150 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +161 +00:12:26,150 --> 00:12:38,990 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +162 +00:12:38,990 --> 00:12:49,780 +علذلك لديك 1.56 وهو 1.65 ومازال التقرير أكبر من + +163 +00:12:49,780 --> 00:12:58,180 +التقرير، لذلك لديك مقارنة سيئة مع .. ولكن إذا + +164 +00:12:58,180 --> 00:13:05,630 +قررتي على هذا بشأن نفسك، ستجد أنه بخير أنا أقصد + +165 +00:13:05,630 --> 00:13:10,650 +بدون أن ننظر إلى الـ HP أو أبل لأنها أكبر من واحد + +166 +00:13:10,650 --> 00:13:17,110 +واحد بخير إذا كانت الـ Asset Test واحدة فهي جيدة + +167 +00:13:17,110 --> 00:13:20,130 +للعمل الآن انظر إلى الـ Account Receivable الـ + +168 +00:13:20,130 --> 00:13:26,590 +Account Receivable هو 7.15 مرات في السنة وهو 6 + +169 +00:13:26,590 --> 00:13:35,530 +مرات في السنة هو أفضل من عمليات الهاتف المستخدم + +170 +00:13:35,530 --> 00:13:37,430 +المستخدم المستخدم المستخدم المستخدم المستخدم + +171 +00:13:37,430 --> 00:13:38,230 +المستخدم المستخدم المستخدم المستخدم المستخدم + +172 +00:13:38,230 --> 00:13:38,430 +المستخدم المستخدم المستخدم المستخدم المستخدم + +173 +00:13:38,430 --> 00:13:39,530 +المستخدم المستخدم المستخدم المستخدم المستخدم + +174 +00:13:39,530 --> 00:13:40,550 +المستخدم المستخدم المستخدم المستخدم المستخدم + +175 +00:13:40,550 --> 00:13:40,830 +المستخدم المستخدم المستخدم المستخدم المستخدم + +176 +00:13:40,830 --> 00:13:40,870 +المستخدم المستخدم المستخدم المستخدم المستخدم + +177 +00:13:40,870 --> 00:13:41,250 +المستخدم المستخدم المستخدم المستخدم المستخدم + +178 +00:13:41,250 --> 00:13:42,590 +المستخدم المستخدم المستخدم المستخدم المستخدم + +179 +00:13:42,590 --> 00:13:48,070 +المستخدم المستخدم المستخدم المستخدم المستخدم + +180 +00:13:48,070 --> 00:13:52,850 +المستخدم الم + +181 +00:13:56,320 --> 00:14:05,940 +التحديث والتحديث العزيزي والتحديث العزيزي والتحديث + +182 +00:14:05,940 --> 00:14:07,480 +العزيزي والتحديث العزيزي والتحديث العزيزي والتحديث + +183 +00:14:07,480 --> 00:14:07,500 +العزيزي والتحديث العزيزي والتحديث العزيزي والتحديث + +184 +00:14:07,500 --> 00:14:07,620 +العزيزي والتحديث العزيزي والتحديث العزيزي والتحديث + +185 +00:14:07,620 --> 00:14:07,840 +العزيزي والتحديث العزيزي والتحديث العزيزي والتحديث + +186 +00:14:07,840 --> 00:14:09,220 +العزيزي والتحديث العزيزي والتحديث العزيزي والتحديث + +187 +00:14:09,220 --> 00:14:16,760 +العزيزي والتحديث العزيزي والتحديث العزيزي والتحديث + +188 +00:14:16,760 --> 00:14:23,180 +العزيزي والتحديث العزيز + +189 +00:14:28,940 --> 00:14:34,600 +تعود إلى الـ checkpoints و تحاول تفكير أين المشكلة + +190 +00:14:34,600 --> 00:14:40,520 +ربما المشكلة في أسعار السوق أو ربما المشكلة في + +191 +00:14:40,520 --> 00:14:47,180 +المال نفسه، فتحاول تفكير و تحكم في المشكلة. الآن + +192 +00:14:47,180 --> 00:14:49,620 +سوف نتحرك إلى الـ capital structure ratios + +193 +00:14:57,800 --> 00:15:03,620 +القيمة الواقعية تقوم + +194 +00:15:03,620 --> 00:15:09,680 +بتقاط مدى ما يعتمد عملية الشركة على المالأو كم + +195 +00:15:09,680 --> 00:15:15,820 +قيمة تستخدمها وكم قيمة تستخدمها ، لذلك كما قلت + +196 +00:15:15,820 --> 00:15:22,140 +قرار اقتصادي مرتبط بالانتصارات الانتصارات + +197 +00:15:22,140 --> 00:15:27,340 +الانتصارات الانتصارات الانتصارات + +198 +00:15:27,340 --> 00:15:29,200 +الانتصارات الانتصارات الانتصارات الانتصارات + +199 +00:15:29,200 --> 00:15:29,320 +الانتصارات الانتصارات الانتصارات الانتصارات + +200 +00:15:29,320 --> 00:15:30,700 +الانتصارات الانتصارات الانتصارات الانتصارات + +201 +00:15:30,700 --> 00:15:30,740 +الانتصارات الانتصارات الانتصارات الانتصارات + +202 +00:15:30,740 --> 00:15:30,800 +الانتصارات الانتصارات الانتصارات الانتصارات + +203 +00:15:30,800 --> 00:15:38,400 +الانتصارات هذا بالنسبة للسياسة المالية، فهو فقط + +204 +00:15:38,400 --> 00:15:42,280 +لأذكركم بمقال T، هنا هي المواصفات الحالية وهنا + +205 +00:15:42,280 --> 00:15:46,620 +المواصفات المقلية التي تنتهي مع المواصفات الكاملة، + +206 +00:15:46,620 --> 00:15:50,760 +والآن هنا هي المواصفات المقلية أو المواصفات + +207 +00:15:50,760 --> 00:15:54,880 +الحالية وهنا لدينا المواصفات المدتنية، هذا الجزء + +208 +00:15:54,880 --> 00:15:56,720 +معروف كمواصفات كامة + +209 +00:16:00,200 --> 00:16:06,900 +والعقود المجتمعية تعتبر عقود وهي الميزة الآن + +210 +00:16:06,900 --> 00:16:13,920 +السؤال هو إذا كانت الشركة تستخدم عقود أو ميزة أو + +211 +00:16:13,920 --> 00:16:14,940 +ميزة أو ميزة أو ميزة أو ميزة أو ميزة أو ميزة أو + +212 +00:16:14,940 --> 00:16:15,680 +ميزة أو ميزة أو ميزة أو ميزة أو ميزة أو ميزة أو + +213 +00:16:15,680 --> 00:16:18,720 +ميزة أو ميزة أو ميزة أو ميزة أو ميزة أو ميزة أو + +214 +00:16:18,720 --> 00:16:20,140 +ميزة أو ميزة أو ميزة أو ميزة أو ميزة أو ميزة أو + +215 +00:16:20,140 --> 00:16:26,180 +ميزة أو ميزة أو ميزة أو ميزة أو + +216 +00:16:26,180 --> 00:16:34,120 +ميزة أو والاقتصاد ما هي أفضل أسلحة لعمل الشباب أفضل + +217 +00:16:34,120 --> 00:16:38,800 +أسلحة لعمل الشباب التي تتجارب أكثر الميزة أو أكثر + +218 +00:16:38,800 --> 00:16:42,340 +ميزة أو أكثر ميزة أو أكثر ميزة أو أكثر ميزة أو + +219 +00:16:42,340 --> 00:16:42,380 +أكثر ميزة أو أكثر ميزة أو أكثر ميزة أو أكثر ميزة + +220 +00:16:42,380 --> 00:16:43,260 +أو أكثر ميزة أو أكثر ميزة أو أكثر ميزة أو أكثر + +221 +00:16:43,260 --> 00:16:44,020 +ميزة أو أكثر ميزة أو أكثر ميزة أو أكثر ميزة أو + +222 +00:16:44,020 --> 00:16:49,500 +أكثر ميزة أو أكثر ميزة أو أكثر ميزة أو أكثر ميزة + +223 +00:16:49,500 --> 00:16:56,870 +أو معرفة قيمة الشركة لا نستطيع نقول 50% هو أفضل + +224 +00:16:56,870 --> 00:17:01,010 +للشركة لا نستطيع نقول 60% أو 70%، فهو يعتمد على + +225 +00:17:01,010 --> 00:17:05,910 +مدى قيمة الشركة هذه هي القيمة الأفضل للشركة تقوم + +226 +00:17:05,910 --> 00:17:15,990 +بمعرفة قيمة الشركة، هذه هي القرارة فقط القيمة + +227 +00:17:15,990 --> 00:17:20,760 +الشركة تتعرف على طريقة إيجار أساتها الشركة كيف + +228 +00:17:20,760 --> 00:17:24,580 +يمكننا تقيم هذا؟ هناك العديد من الحيوانات التي + +229 +00:17:24,580 --> 00:17:27,680 +يمكننا تقيمها والحيوانات المهمة هي الحيوانات الـ + +230 +00:17:27,680 --> 00:17:36,480 +Debt وحيوانات الوقت المهتم بالها فالأولة التي هي + +231 +00:17:36,480 --> 00:17:40,500 +الحيوانات الـ Debt هي ترميها كعامل المساعدة + +232 +00:17:40,500 --> 00:17:43,200 +المجتمعية المجتمعية المجتمعية المجتمعية المجتمعية + +233 +00:17:43,200 --> 00:17:46,380 +المجتمعية المجتمعية المجتمعية المجتمعية المجتمعية + +234 +00:17:46,380 --> 00:17:47,620 +المجتمعية المجتمعية المجتمعية المجتمعية المجتمعية + +235 +00:17:47,620 --> 00:17:48,060 +المجتمعية المجتمعية المجتمعية المجتمعية المجتمعية + +236 +00:17:48,060 --> 00:17:48,220 +المجتمعية المجتمعية المجتمعية المجتمعية المجتمعية + +237 +00:17:48,220 --> 00:17:56,160 +المجتمعية من أين ندفع الواقعات الكاملة؟ أو كم + +238 +00:17:56,160 --> 00:18:03,140 +نستخدم المال لدفع الواقعات الكاملة؟ لذلك نستطيع + +239 +00:18:03,140 --> 00:18:06,760 +تطبيق هذا الوضع بـ Total Liabilities ÷ Total + +240 +00:18:06,760 --> 00:18:20,350 +Assets وعندما نفعل هذا نحصل على 1012.50 ÷ 1764 نحصل + +241 +00:18:20,350 --> 00:18:29,810 +على نتيجة 57.40% ما يعنيه هذا الوضع فالنتيجة هي + +242 +00:18:29,810 --> 00:18:34,590 +حوالي 57% ما يعنيه هذا الوضع + +243 +00:18:38,090 --> 00:18:44,570 +ماذا يعني ال 57%؟ يعني أن 57% من مالاتنا هي + +244 +00:18:44,570 --> 00:18:52,850 +المال المالية نعم من المال ما هي المال؟ ما هي + +245 +00:18:52,850 --> 00:18:56,130 +المساعدات الكاملة ما هي المساعدات الكاملة قصة قصة قصة + +246 +00:18:56,130 --> 00:18:58,910 +قصة قصة قصة قصة قصة قصة قصة قصة قصة قصة قصة + +247 +00:18:58,910 --> 00:18:59,570 +قصة قصة قصة قصة قصة قصة قصة قصة قصة قصة قصة + +248 +00:18:59,570 --> 00:19:00,990 +قصة قصة قصة قصة قصة قصة قصة قصة قصة قصة قصة + +249 +00:19:00,990 --> 00:19:02,610 +قصة قصة قصة ق + +250 +00:19:05,420 --> 00:19:10,660 +على سبيل المثال أعطيك الأساتيات الأساتيات الكاملة + +251 +00:19:10,660 --> 00:19:17,520 +و أعطيك الميزانية ثم أنا أغلق ما هي الميزانيات إذا + +252 +00:19:17,520 --> 00:19:21,860 +أعطيك الميزانيات الأقصر فباستخدام + +253 +00:19:21,860 --> 00:19:25,680 +هذه الميزانية تستطيع أن تعطي الميزانيات الأطول + +254 +00:19:25,680 --> 00:19:31,280 +الميزانيات الكاملة ثم الميزانية الكاملة هي + +255 +00:19:31,280 --> 00:19:34,220 +الميزانية أقل الميزانية أقل الميزانية + +256 +00:19:36,680 --> 00:19:41,700 +العقل الكام لو كنت تعرف العقل الكام وكنت تعرف + +257 +00:19:41,700 --> 00:19:46,520 +العقل الأقل يمكنك أن تعرف العقل الأطول، لهذا السبب + +258 +00:19:46,520 --> 00:19:50,980 +أنا أحاول أن أتعرف على إجابتك، فهذه هي المقالات، + +259 +00:19:50,980 --> 00:19:59,040 +ثم تذهب حتى تخلص العقل الأقل والعقل الأطول من + +260 +00:19:59,040 --> 00:19:59,660 +المقالة + +261 +00:20:02,470 --> 00:20:08,710 +حسنًا، فالسؤال الآن هو إذا كان أكثر من نصف من + +262 +00:20:08,710 --> 00:20:13,670 +الأموال الكاملة مدفونة من المال، هل تعتقد أن هذا + +263 +00:20:13,670 --> 00:20:21,130 +خطر للعمل؟ نعم، لأن أكثر من 50% من الأموال مدفونة، + +264 +00:20:21,130 --> 00:20:26,090 +هذا يعني أن الآخر نصف منها مدفونة من المال + +265 +00:20:29,770 --> 00:20:33,410 +تقريبًا تقريبًا تقريبًا تقريبًا تقريبًا تقريبًا تقريبًا + +266 +00:20:33,410 --> 00:20:36,270 +تقريبًا تقريبًا تقريبًا تقريبًا تقريبًا تقريبًا تقريبًا + +267 +00:20:36,270 --> 00:20:36,810 +تقريبًا تقريبًا تقريبًا تقريبًا تقريبًا تقريبًا تقريبًا + +268 +00:20:36,810 --> 00:20:37,850 +تقريبًا تقريبًا تقريبًا تقريبًا تقريبًا تقريبًا تقريبًا + +269 +00:20:37,850 --> 00:20:37,890 +تقريبًا تقريبًا تقريبًا تقريبًا تقريبًا تقريبًا تقريبًا + +270 +00:20:37,890 --> 00:20:38,070 +تقريبًا تقريبًا تقريبًا تقريبًا تقريبًا تقريبًا تقريبًا + +271 +00:20:38,070 --> 00:20:38,090 +تقريبًا تقريبًا تقريبًا + +272 +00:20:44,700 --> 00:20:48,560 +أي أسئلة في هذه المقارنة؟ هناك الكثير من المقارنات + +273 +00:20:48,560 --> 00:20:52,520 +الأخرى مرتبطة بها ولكننا نركز هنا على المقارنات + +274 +00:20:52,520 --> 00:20:58,680 +المهمة. المقارنة الثانوية هي الوقت المهتم. هذه + +275 +00:20:58,680 --> 00:21:05,640 +مقارنة كم مرة تغطي شركة شركة شركة شركة شركة شركة + +276 +00:21:05,640 --> 00:21:08,000 +شركة شركة شركة شركة شركة شركة شركة شركة شركة شركة + +277 +00:21:08,000 --> 00:21:11,480 +شركة شركة شركة شركة شركة شركة شركة + +278 +00:21:11,480 --> 00:21:12,700 +شركة شركة شركة شركة شركة شركة شركة شركة شركة شركة + +279 +00:21:12,700 --> 00:21:18,130 +شركة شركة شركة شرك بقيمة الهجوم والتأكيد + +280 +00:21:18,130 --> 00:21:27,230 +هو عدد المرات وكما ترى هنا 5.38 مرات ما يعني هذا + +281 +00:21:27,230 --> 00:21:34,850 +يعني أن عمل الهجوم أو عمل الهجوم عمل الهجوم + +282 +00:21:34,850 --> 00:21:35,130 +يغطي + +283 +00:21:42,380 --> 00:21:46,880 +الدفع هو 5 + +284 +00:21:46,880 --> 00:21:51,420 +.8 مرات، في + +285 +00:21:51,420 --> 00:21:56,000 +كلمات أخرى، يمكننا أن نضعها بطرق مختلفة، فقط + +286 +00:21:56,000 --> 00:22:01,200 +نقل 1 إلى 5.38 + +287 +00:22:03,370 --> 00:22:14,030 +فاعلها واحد مقابل 5.38 هو حوالي 13% 14% 18% نعم + +288 +00:22:14,030 --> 00:22:24,310 +فقط قبل واحد واحد مقابل 5.38 18 + +289 +00:22:24,310 --> 00:22:32,490 +% ماذا يعني هذا يعني + +290 +00:22:34,330 --> 00:22:44,710 +الدفع الهجومي يمثل 18% من الدفع الهجومي يمثل + +291 +00:22:44,710 --> 00:22:48,870 +18% من الدفع الهجومي على سبيل المثال إذا كان لديك + +292 +00:22:48,870 --> 00:23:03,450 +100$ كدفع هجومي منهم 18$ كدفع هجومي 18% يعني + +293 +00:23:04,730 --> 00:23:11,890 +الدفعات أو دفعات الدفع تمثل 18% من الدفع العام في + +294 +00:23:11,890 --> 00:23:22,090 +كلمة أخرى إذا كان لديك دفع عام 100$ منهم 18$ يجب + +295 +00:23:22,090 --> 00:23:27,430 +أن تدفعهم كدفع دفع دفع دفع دفع دفع دفع دفع دفع + +296 +00:23:27,430 --> 00:23:27,650 +دفع دفع دفع دفع دفع دفع دفع دفع دفع دفع دفع + +297 +00:23:27,650 --> 00:23:30,170 +دفع دفع دفع دفع دفع دفع دفع دفع + +298 +00:23:31,560 --> 00:23:38,100 +5.38 مرات تزداد، على سبيل المثال، إذا كانت مجموعة + +299 +00:23:38,100 --> 00:23:46,640 +الأعضاء 9 مرات، ماذا تعتقد؟ هل هذا أفضل للعمل أو + +300 +00:23:46,640 --> 00:23:53,020 +ماذا تعتقد؟ لديه 9 مرات أو 5 مرات، وهو جيد للعمل؟ + +301 +00:23:54,560 --> 00:23:59,220 +five times okay let's agree with you that five + +302 +00:23:59,220 --> 00:24:02,460 +times is much better than this do it in different + +303 +00:24:02,460 --> 00:24:07,040 +way let's think in a different way okay so we + +304 +00:24:07,040 --> 00:24:11,560 +divided one five point three eights حكينا عن ال + +305 +00:24:11,560 --> 00:24:16,730 +five point three eights times مع ذلك الوقت .. الوقت + +306 +00:24:16,730 --> 00:24:20,590 +الذي يتم تغييره الهدف يعني كم مرة تغير الهدف + +307 +00:24:20,590 --> 00:24:27,470 +التجاربية تغطي أسعار الهدف، حسنًا؟ لذلك .. نحن نفضل + +308 +00:24:27,470 --> 00:24:34,070 +أن هذا الـT يكون عاليًا لعمل الشركة، حسنًا؟ هذه + +309 +00:24:34,070 --> 00:24:40,770 +التحقيقات تساعدك في فهم مقاومة المال إذا + +310 +00:24:40,770 --> 00:24:46,380 +قمت بقراءة هذا المثال هنا هي تكون لديك المال الكامل + +311 +00:24:46,380 --> 00:24:53,260 +لـ Home Depots وLouis لديك المال الكامل للعامة + +312 +00:24:53,260 --> 00:24:54,840 +العامة العامة العامة العامة العامة العامة العامة + +313 +00:24:54,840 --> 00:24:55,560 +العامة العامة العامة العامة العامة العامة العامة + +314 +00:24:55,560 --> 00:24:56,060 +العامة العامة العامة العامة العامة العامة العامة + +315 +00:24:56,060 --> 00:24:57,300 +العامة العامة العامة العامة العامة العامة العامة + +316 +00:24:57,300 --> 00:24:58,100 +العامة العامة العامة العامة العامة العامة العامة + +317 +00:24:58,100 --> 00:25:00,980 +العامة العامة العامة العامة العامة العامة العامة + +318 +00:25:00,980 --> 00:25:05,040 +العامة العامة العامة العامة العامة العامة العامة + +319 +00:25:05,040 --> 00:25:09,240 +العامة + +320 +00:25:09,240 --> 00:25:15,110 +العام in Home Depots and Louis is 43 percent it means + +321 +00:25:15,110 --> 00:25:20,010 +the debt ratio in Home Depots is higher than the + +322 +00:25:20,010 --> 00:25:27,330 +Louis the time interest earned is 24 and in Louis is + +323 +00:25:27,330 --> 00:25:32,170 +33 what it means then what it means the 24 for + +324 +00:25:32,170 --> 00:25:40,070 +Home Depots and 33 for Louis the times interest earned + +325 +00:25:40,070 --> 00:25:45,550 +which is preferable + +326 +00:25:45,550 --> 00:25:54,630 +33 okay what it means 33 how much interest from + +327 +00:25:54,630 --> 00:25:58,790 +mine how much I pay for the loans the interest + +328 +00:25:58,790 --> 00:26:03,210 +from the loans again say it again the interest + +329 +00:26:03,210 --> 00:26:07,220 +that I pay for the loans how much interest you + +330 +00:26:07,220 --> 00:26:16,740 +mean how much times no look + +331 +00:26:16,740 --> 00:26:24,820 +at this 33 here 33 this is not interest times what + +332 +00:26:24,820 --> 00:26:28,820 +it means exactly what it means say it again how + +333 +00:26:28,820 --> 00:26:29,200 +many times + +334 +00:26:33,260 --> 00:26:36,700 +no how much is the operating income cover from the + +335 +00:26:36,700 --> 00:26:40,840 +interest yes so this is different things we may + +336 +00:26:40,840 --> 00:26:43,960 +give you like true or false and we will say this + +337 +00:26:43,960 --> 00:26:47,200 +is what you say is false but what she said is true + +338 +00:26:47,200 --> 00:26:52,140 +so how many times that the operating income covers + +339 +00:26:52,140 --> 00:26:58,650 +the interest expense okay so be careful in هو كيف + +340 +00:26:58,650 --> 00:27:06,430 +تقوم بتحسين المقارنة وهذه + +341 +00:27:06,430 --> 00:27:13,050 +هي الحلقة لـ Capital Structure على سبيل المثال + +342 +00:27:13,050 --> 00:27:18,090 +الآن سنتحدث عن مقارنة الوثيقة الهجومية الهجومية + +343 +00:27:18,090 --> 00:27:25,170 +الهجومية الهجومية الهجومية الهجومية + +344 +00:27:25,170 --> 00:27:25,670 +الهجومية + +345 +00:27:29,650 --> 00:27:33,210 +مقارنة فعالية عملية أصول تقوم بمقارنة فعالية + +346 +00:27:33,210 --> 00:27:37,150 +عملية أصول في استخدام أصولها لإنتاج سائل. السؤال + +347 +00:27:37,150 --> 00:27:43,490 +الكبير لهذا هو إلى ما يستخدم أصول الأصول التي + +348 +00:27:43,490 --> 00:27:47,790 +يحتوي على أصول كاملة وأصول مستقلة لإنتاج أو إنتاج + +349 +00:27:47,790 --> 00:27:54,330 +سائل، لذلك أكثر أصول تنتج سائل، أكثر أصول تنتج + +350 +00:27:54,330 --> 00:28:01,020 +سائل، أكثر أصول تنتج سائل، أكثر أصول تنتج بإمكاننا + +351 +00:28:01,020 --> 00:28:05,060 +تغطي هذا باستخدام مقارنة الـ turnover للأموال من + +352 +00:28:05,060 --> 00:28:07,920 +الأموال الكاملة للأموال الكاملة للأموال المقاومة + +353 +00:28:07,920 --> 00:28:10,120 +المقاومة المقاومة المقاومة المقاومة المقاومة + +354 +00:28:10,120 --> 00:28:10,840 +المقاومة المقاومة المقاومة المقاومة المقاومة + +355 +00:28:10,840 --> 00:28:11,120 +المقاومة المقاومة المقاومة المقاومة المقاومة + +356 +00:28:11,120 --> 00:28:11,260 +المقاومة المقاومة المقاومة المقاومة المقاومة + +357 +00:28:11,260 --> 00:28:11,760 +المقاومة المقاومة المقاومة المقاومة المقاومة + +358 +00:28:11,760 --> 00:28:12,060 +المقاومة المقاومة المقاومة المقاومة المقاومة + +359 +00:28:12,060 --> 00:28:16,840 +المقاومة المقاومة المقاومة المقا + +360 +00:28:17,490 --> 00:28:26,530 +مقارنة بـ 191 لديك 1.37 ما يعنيه .. ما يعنيه أن 1 + +361 +00:28:26,530 --> 00:28:33,070 +دولار مستثمر في الاستخدام المجموعة يجري 1.37 سلسلة + +362 +00:28:33,070 --> 00:28:38,750 +أو 1 دولار في السلسلة إذا كنت تقارن هذا مع ال .. + +363 +00:28:38,750 --> 00:28:45,830 +مع المجموعة المشرفة ترى أن شركتنا أفضل من المجموعة + +364 +00:28:45,830 --> 00:28:50,570 +المشرفة Okay, just to prepare your mind in terms of + +365 +00:28:50,570 --> 00:28:53,630 +your assignments, how we calculate the peer group, + +366 +00:28:54,110 --> 00:28:56,930 +the peer group is the average of the industry, so + +367 +00:28:56,930 --> 00:28:59,350 +be careful when you are writing your assignment on + +368 +00:28:59,350 --> 00:29:03,170 +this, and إن شاء الله after the mid exam, I will + +369 +00:29:03,170 --> 00:29:07,110 +arrange a meeting for you to train you how to + +370 +00:29:07,110 --> 00:29:09,650 +write your assignments or how to write academic + +371 +00:29:09,650 --> 00:29:11,230 +assignments, okay? + +372 +00:29:14,440 --> 00:29:22,880 +للعام 2009 تقريبًا تقريبًا تقريبًا تقريبًا + +373 +00:29:22,880 --> 00:29:28,880 +تقريبًا تقريبًا + +374 +00:29:28,880 --> 00:29:32,700 +تقريبًا تقريبًا تقريبًا تقريبًا تقريبًا تقريبًا + +375 +00:29:32,700 --> 00:29:33,000 +تقريبًا تقريبًا تقريبًا تقريبًا تقريبًا تقريبًا + +376 +00:29:33,000 --> 00:29:33,020 +تقريبًا تقريبًا تقريبًا تقريبًا تقريبًا تقريبًا + +377 +00:29:33,020 --> 00:29:38,120 +تقريبًا تقريبًا تقريبًا تقريبًا + +378 +00:29:38,120 --> 00:29:44,140 +تقريبًا تقريبًا + +379 +00:29:44,140 --> 00:29:48,850 +تقريبًا أين نستطيع الحصول على الواقعيات الواقعية + +380 +00:29:48,850 --> 00:29:54,390 +تأتي من الواقعيات + +381 +00:29:54,390 --> 00:29:55,890 +المستقلة المستقلة المستقلة المستقلة المستقلة + +382 +00:29:55,890 --> 00:29:55,910 +المستقلة المستقلة المستقلة المستقلة المستقلة + +383 +00:29:55,910 --> 00:29:56,350 +المستقلة المستقلة المستقلة المستقلة المستقلة + +384 +00:29:56,350 --> 00:30:00,050 +المستقلة المستقلة المستقلة المستقلة المستقلة + +385 +00:30:00,050 --> 00:30:05,750 +المستقلة المستقلة المستقلة المستقلة المستقلة + +386 +00:30:05,750 --> 00:30:06,810 +المستقلة المستقلة المستقلة المستقلة المستقلة + +387 +00:30:06,810 --> 00:30:09,890 +المستقلة المستقلة المستقلة المستقلة المستقلة + +388 +00:30:09,890 --> 00:30:10,130 +المستقلة المستقلة المستقلة المستقلة المستقلة + +389 +00:30:10,130 --> 00:30:16,570 +المستقلة المستقلة المستقلة نحصل في عام 2009 1.94$ 1 + +390 +00:30:16,570 --> 00:30:21,610 +.94$ يعني أن 1 دولار مستقبله في مصالح مستقبل + +391 +00:30:21,610 --> 00:30:24,490 +مستقبل مستقبل مستقبل 1.94$ + +392 +00:30:36,170 --> 00:30:42,050 +حسنًا، إذا قمت بتجميلهم جميعًا، ستحصل على نسبة 1.37 + +393 +00:30:42,050 --> 00:30:43,130 +أكثر من أكثر من أكثر من أكثر من أكثر من أكثر من + +394 +00:30:43,130 --> 00:30:44,410 +أكثر من أكثر من أكثر من أكثر من أكثر من أكثر من + +395 +00:30:44,410 --> 00:30:45,310 +أكثر من أكثر من أكثر من أكثر من أكثر من أكثر من + +396 +00:30:45,310 --> 00:30:48,030 +أكثر من أكثر من أكثر من أكثر من أكثر من أكثر من + +397 +00:30:48,030 --> 00:30:53,370 +أكثر من أكثر من أكثر من أكثر من أكثر من أكثر من + +398 +00:30:53,370 --> 00:30:59,630 +أكثر من أكثر + +399 +00:30:59,630 --> 00:31:02,910 +من أك + +400 +00:31:03,810 --> 00:31:07,930 +Receivable turnover و Inventory turnover Receivable + +401 +00:31:07,930 --> 00:31:12,970 +turnover مدى إلى مدى ما أو كم طول من الشركة + +402 +00:31:12,970 --> 00:31:18,510 +لتحويل الـ Account receivable إلى الـ Cash أو ماهي + +403 +00:31:18,510 --> 00:31:24,310 +فترة التحويل لـ Account receivable كيف نستطيع تخطيط + +404 +00:31:24,310 --> 00:31:28,430 +هذا؟ Receivable turnover هو مجموعات المدفوعات + +405 +00:31:28,430 --> 00:31:33,820 +المقاومة بمجموعة الـ Account receivable وهو 16.67 + +406 +00:31:33,820 --> 00:31:40,040 +مرات وهذا في الوقت وإذا أردنا تحويل هذا إلى أيام + +407 +00:31:40,040 --> 00:31:48,940 +يمكنك تحويله إلى 365 مرات و 16.67 مرات وستحصل على + +408 +00:31:48,940 --> 00:31:49,840 +عدد الأيام + +409 +00:31:53,120 --> 00:31:57,880 +So the more times you are circulating .. the more + +410 +00:31:57,880 --> 00:32:00,880 +times you are circulating the account receivable, + +411 +00:32:01,420 --> 00:32:04,860 +the less number of days you need to convert + +412 +00:32:04,860 --> 00:32:09,460 +account receivable into cash So say it again, the + +413 +00:32:09,460 --> 00:32:14,160 +more time that we have to convert account + +414 +00:32:14,160 --> 00:32:18,620 +receivable into cash, the less number of days that + +415 +00:32:18,620 --> 00:32:24,470 +we need to convert account receivable into cash على + +416 +00:32:24,470 --> 00:32:31,830 +سبيل المثال إذا كانت شركة A الـ account turnover + +417 +00:32:31,830 --> 00:32:42,130 +لشركة A هي 17 مرات ولكن لشركة B هي 15 مرات لذلك + +418 +00:32:42,130 --> 00:32:49,810 +نحن نفضل A لأن A لديها مجتمع أفضل من شركة B هذا + +419 +00:32:49,810 --> 00:32:56,980 +يعني الشركة لديها أقل أيام لتحويل أصولها لتحويل الـ + +420 +00:32:56,980 --> 00:32:59,540 +account receivable إلى الـ cash كيف يمكننا التخيل + +421 +00:32:59,540 --> 00:33:07,080 +هذا فقط 365 مقاطع 17 و 365 مقاطع 15 مقاطع 365 + +422 +00:33:07,080 --> 00:33:08,700 +مقاطع 16 مقاطع 16 مقاطع 15 مقاطع 16 مقاطع 16 مقاطع + +423 +00:33:08,700 --> 00:33:08,980 +16 مقاطع 16 مقاطع 16 مقاطع 16 مقاطع 16 مقاطع 16 + +424 +00:33:08,980 --> 00:33:12,230 +مقاطع 16 مقاطع 16 مقاطع 16 مقاطع 16 21 أيام و 24 + +425 +00:33:12,230 --> 00:33:16,410 +أيام لذلك نحتاج 21 يومًا هنا لتحويل الاسم المستقبلي + +426 +00:33:16,410 --> 00:33:21,350 +إلى cash ولكن هنا نحتاج 24 يومًا لتحويل الاسم + +427 +00:33:21,350 --> 00:33:27,530 +المستقبلي إلى cash الآن للإيقاع التحويل المستقبلي + +428 +00:33:27,530 --> 00:33:28,810 +نفس الأشياء + +429 +00:33:32,580 --> 00:33:35,860 +يمكن أن يتم تخطيطه بقيمة الأسعار التي تم تحويلها + +430 +00:33:35,860 --> 00:33:37,080 +إلى الأسعار التي تم تحويلها إلى الأسعار التي تم + +431 +00:33:37,080 --> 00:33:37,540 +تحويلها إلى الأسعار التي تم تحويلها إلى الأسعار + +432 +00:33:37,540 --> 00:33:39,080 +التي تم تحويلها إلى الأسعار التي تم تحويلها إلى + +433 +00:33:39,080 --> 00:33:41,840 +الأسعار التي تم تحويلها إلى الأسعار التي تم + +434 +00:33:41,840 --> 00:33:43,680 +تحويلها إلى الأسعار التي تم تحويلها إلى الأسعار + +435 +00:33:43,680 --> 00:33:46,240 +التي تم تحويلها إلى الأسعار التي تم تحويلها إلى + +436 +00:33:46,240 --> 00:33:48,400 +الأسعار التي تم تحويلها إلى الأسعار التي تم + +437 +00:33:48,400 --> 00:33:49,300 +تحويلها إلى الأسعار التي تم تحويلها إلى الأسعار + +438 +00:33:49,300 --> 00:33:52,080 +التي تم تحويلها إلى الأسعار التي تم تحويلها إلى + +439 +00:33:52,080 --> 00:33:57,040 +الأسعار التي تم تحويلها إلى الأسعار التي بالنسبة + +440 +00:33:57,040 --> 00:34:05,340 +للساعات فقط قمنا بتقسيمها من 365 إلى 3.36 ونحتاج + +441 +00:34:05,340 --> 00:34:13,240 +حوالي 92 أو 93 يومًا لـ .. 109 + +442 +00:34:13,240 --> 00:34:20,820 +أيام لتحويل المصادر إلى المال أو لـ 10 عبر المصادر + +443 +00:34:20,820 --> 00:34:24,360 +لـ 10 عبر المصادر + +444 +00:34:28,620 --> 00:34:33,520 +عندما نضيف جميع النتائج مع بعض نحو الـ 10 عشوائية + +445 +00:34:33,520 --> 00:34:36,660 +عشوائية عشوائية عشوائية عشوائية عشوائية عشوائية + +446 +00:34:36,660 --> 00:34:37,960 +عشوائية عشوائية عشوائية عشوائية عشوائية عشوائية + +447 +00:34:37,960 --> 00:34:38,500 +عشوائية عشوائية عشوائية عشوائية عشوائية عشوائية + +448 +00:34:38,500 --> 00:34:39,100 +عشوائية عشوائية عشوائية عشوائية عشوائية عشوائية + +449 +00:34:39,100 --> 00:34:51,240 +عشوائية عشوائية عشوائية عش + +450 +00:34:54,020 --> 00:34:59,280 +we just put click on the ... on the ... on the one that + +451 +00:34:59,280 --> 00:35:02,680 +we prefer for this is preferable, the password is + +452 +00:35:02,680 --> 00:35:05,040 +preferable and in terms of fixed asset is + +453 +00:35:05,040 --> 00:35:09,080 +preferable ... preferable too and in receivable as + +454 +00:35:09,080 --> 00:35:13,420 +well, so ... but we have problems in inventory + +455 +00:35:13,420 --> 00:35:20,280 +turnover المجموعات مخصصة ومفيدة أكثر من المجموعات + +456 +00:35:20,280 --> 00:35:24,220 +المخصصة أيضًا مفيدة أكثر من المجموعات المخصصة + +457 +00:35:24,220 --> 00:35:30,920 +ومخصصة التجارب مخصصة أيضًا ولكن المشكلة في تغيير + +458 +00:35:30,920 --> 00:35:36,240 +المخصصة لذلك يجب أن نعرف لماذا هذه المشكلة ربما + +459 +00:35:36,240 --> 00:35:41,670 +لدينا مخصصة تغيير وربما ندفع المال أكثر إلى + +460 +00:35:41,670 --> 00:35:47,170 +الْمَصَادِرِ و نبقى بعض المواد غير محتاجة مواد غير + +461 +00:35:47,170 --> 00:35:52,450 +محتاجة في المصادر، يجب أن نفكر في طرق المصادر، + +462 +00:35:52,450 --> 00:35:55,850 +يمكننا أن نستخدم طرق غير مفيدة في البقاء في + +463 +00:35:55,850 --> 00:36:00,450 +المصادربعض الشركات تستخدم just in time وبعض الشركات + +464 +00:36:00,450 --> 00:36:06,470 +تستخدم طرح أخرى لتعامل الانفجار لذلك يمكن أن + +465 +00:36:06,470 --> 00:36:14,190 +تركز على الانفجار و تحسن الوضع هنا سوف نتحدث الآن + +466 +00:36:14,190 --> 00:36:19,050 +عن مقارنة الفائزة هل هناك أسئلة قبل أن نتحرك إلى + +467 +00:36:19,050 --> 00:36:20,610 +مقارنة الفائزة؟ + +468 +00:36:28,180 --> 00:36:33,780 +Okay, any question? + +469 +00:36:33,780 --> 00:36:38,480 +Okay, the profitability ratios measures to the + +470 +00:36:38,480 --> 00:36:42,260 +extent that business generate profits from + +471 +00:36:42,260 --> 00:36:46,820 +different areas from the gross, from the operating + +472 +00:36:46,820 --> 00:36:54,860 +and after paying interest and taxes وهي الأشياء + +473 +00:36:54,860 --> 00:36:56,880 +الرئيسية، الأشياء الثانوية تساعدنا في تحقيق + +474 +00:36:56,880 --> 00:36:57,680 +الميزانيات في تحقيق الميزانيات تساعدنا في تحقيق + +475 +00:36:57,680 --> 00:37:00,160 +الميزانيات تساعدنا في تحقيق الميزانيات تساعدنا في + +476 +00:37:00,160 --> 00:37:03,840 +تحقيق الميزانيات تساعدنا في تحقيق الميزانيات + +477 +00:37:03,840 --> 00:37:05,960 +تساعدنا في تحقيق الميزانيات تساعدنا في تحقيق + +478 +00:37:05,960 --> 00:37:06,460 +الميزانيات تساعدنا في تحقيق الميزانيات تساعدنا في + +479 +00:37:06,460 --> 00:37:10,500 +تحقيق الميزانيات تساعدنا في تحقيق الميزانيات + +480 +00:37:10,500 --> 00:37:19,040 +تساعدنا في تحقيق الميزانيات تساعدنا + +481 +00:37:19,040 --> 00:37:22,120 +في تحقيق الميزانية + +482 +00:37:26,740 --> 00:37:32,100 +إذا اتجارات أساسية فأنّ الانتجارات الأولى هي التحكم + +483 +00:37:32,100 --> 00:37:36,620 +بالسعر كيف ننظر إلى السعر ونعرف أن السعر يأتي من + +484 +00:37:36,620 --> 00:37:40,120 +السعر الخاص بالمواد التي يتم تحقيقها ويأتي من + +485 +00:37:40,120 --> 00:37:42,240 +السعر الخاص بالمواد التي يتم تحقيقها ويأتي من + +486 +00:37:42,240 --> 00:37:43,520 +السعر الخاص بالمواد التي يتم تحقيقها ويأتي من + +487 +00:37:43,520 --> 00:37:43,620 +السعر الخاص بالمواد التي يتم تحقيقها ويأتي من + +488 +00:37:43,620 --> 00:37:44,180 +السعر الخاص بالمواد التي يتم تحقيقها ويأتي من + +489 +00:37:44,180 --> 00:37:46,320 +السعر الخاص بالمواد التي يتم تحقيقها ويأتي من + +490 +00:37:46,320 --> 00:37:46,960 +السعر الخاص بالمواد التي يتم تحقيقها ويأتي من + +491 +00:37:46,960 --> 00:37:55,580 +السعر الخاص بالمواد التي يتم تحقيقها و + +492 +00:37:57,680 --> 00:38:01,960 +عن كيفية استخدام السوق وكيفية إدارة الأجهزة + +493 +00:38:01,960 --> 00:38:07,380 +والأجهزة والشبكات في إجراء السوق، فنحن نبحث عن + +494 +00:38:07,380 --> 00:38:11,260 +الاثنين الأهم الأشياء عندما نقوم بالتأكيد عمليات + +495 +00:38:11,260 --> 00:38:19,560 +التسريب والسعر والإيقاف من استخدام السوق. الأول هو + +496 +00:38:19,560 --> 00:38:24,560 +عمليات التسريب عمليات التسريب هي عمليات التسريب + +497 +00:38:24,560 --> 00:38:25,900 +مقاطعة بالسوق + +498 +00:38:28,400 --> 00:38:37,380 +وإذا تخطط هذا الـ Gross Profits 650 مليون و 2500 + +499 +00:38:37,380 --> 00:38:47,360 +مليون، فتحصل على 26% 26% يعني أن 1 دولار في السوق + +500 +00:38:47,360 --> 00:38:54,350 +يحصل على 26 دولار as gross profits so it means in + +501 +00:38:54,350 --> 00:38:58,010 +other words one dollar in sales this is the one + +502 +00:38:58,010 --> 00:39:06,790 +dollar in sales twenty six cents is gross profits + +503 +00:39:06,790 --> 00:39:18,550 +and seventy four is cost of goods so we think that + +504 +00:39:18,550 --> 00:39:24,140 +this is high إذا كنت تنظر إلى هذه المنطقة هنا هي + +505 +00:39:24,140 --> 00:39:30,040 +عالية لأن هناك ... نعم هناك مكان لاستخدام أسعار + +506 +00:39:30,040 --> 00:39:34,640 +أخرى ولكن لاحقًا هذا مقارنة مع ... مع أسعار الأسعار + +507 +00:39:34,640 --> 00:39:41,520 +قليلًا، لذلك بخير إذا كنا نفكر في كيف نحفظ أسعار + +508 +00:39:41,520 --> 00:39:45,580 +الأسعار ونفكر في كيف نستطيع تنظيم هذا + +509 +00:39:52,440 --> 00:39:56,780 +الثاني هو مقارنة + +510 +00:39:56,780 --> 00:39:57,940 +الناتج الناتج الناتج الناتج الناتج الناتج الناتج + +511 +00:39:57,940 --> 00:39:58,780 +الناتج الناتج الناتج الناتج الناتج الناتج الناتج + +512 +00:39:58,780 --> 00:39:59,720 +الناتج الناتج الناتج الناتج الناتج الناتج الناتج + +513 +00:39:59,720 --> 00:39:59,880 +الناتج الناتج الناتج الناتج الناتج الناتج الناتج + +514 +00:39:59,880 --> 00:40:00,040 +الناتج الناتج الناتج الناتج الناتج الناتج الناتج + +515 +00:40:00,040 --> 00:40:00,080 +الناتج الناتج الناتج الناتج الناتج الناتج الناتج + +516 +00:40:00,080 --> 00:40:14,960 +الناتج الناتج الناتج الناتج النا + +517 +00:40:16,110 --> 00:40:18,790 +والحصول على مستخدم مستخدم مستخدم مستخدم مستخدم + +518 +00:40:18,790 --> 00:40:19,430 +مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم + +519 +00:40:19,430 --> 00:40:21,210 +مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم + +520 +00:40:21,210 --> 00:40:22,270 +مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم + +521 +00:40:22,270 --> 00:40:26,230 +مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم + +522 +00:40:26,230 --> 00:40:28,030 +مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم + +523 +00:40:28,030 --> 00:40:28,350 +مستخدم مستخدم مستخدم مستخ + +524 +00:40:31,600 --> 00:40:36,920 +مرة أخرى نحن لدينا 26% من مجموعات البروفيت والنت + +525 +00:40:36,920 --> 00:40:41,200 +البروفيت + +526 +00:40:41,200 --> 00:40:49,420 +المعمل هو 14% فقط انظر لهذا وانظر لهذا لماذا + +527 +00:40:49,420 --> 00:40:52,600 +مجموعات + +528 +00:40:52,600 --> 00:40:58,420 +البروفيت المعمل أو البروفيت المعمل تتخلص من 14%؟ + +529 +00:40:58,420 --> 00:41:04,660 +نعم أي مقارنة؟ أنت محق مقارنة عملية عملية عملية + +530 +00:41:04,660 --> 00:41:06,420 +عملية عملية عملية عملية عملية عملية عملية عملية + +531 +00:41:06,420 --> 00:41:10,240 +عملية عملية عملية + +532 +00:41:10,240 --> 00:41:12,200 +عملية عملية عملية عملية عملية عملية عملية عملية + +533 +00:41:12,200 --> 00:41:12,320 +عملية عملية عملية عملية عملية عملية عملية عملية + +534 +00:41:12,320 --> 00:41:12,340 +عملية عملية عملية عملية عملية عملية عملية عملية + +535 +00:41:12,340 --> 00:41:12,720 +عملية عملية عملية عملية عملية عملية عملية عملية + +536 +00:41:12,720 --> 00:41:12,740 +عملية عملية عملية عملية عملية عملية عملية عملية + +537 +00:41:12,740 --> 00:41:29,780 +عملية عملية عملية عملية عملية عملية عمل + +538 +00:41:30,730 --> 00:41:36,770 +على سبيل المثال في هذا البرنامج نحتاج 74% من + +539 +00:41:36,770 --> 00:41:41,690 +الأسعار لتغطي أسعار الأسعار والباقية هي البرنامج + +540 +00:41:41,690 --> 00:41:47,990 +العامة ولكن هنا نحتاج 12% لتغطي الأسعار الأسعار + +541 +00:41:47,990 --> 00:41:55,010 +العملية، فالاثنين الأشياء مهمة + +542 +00:41:55,010 --> 00:42:03,790 +بالمقارنة مع المجموعة العامة هي 15% وهو أكثر من + +543 +00:42:03,790 --> 00:42:11,710 +شركتنا، أو شركتنا، لذلك يعني أنها أقل فائدة من + +544 +00:42:11,710 --> 00:42:16,970 +مجموعة العضلات، حسنًا، + +545 +00:42:16,970 --> 00:42:23,170 +لـ 2009، إذا تخططنا هذا لـ 2009، مجموعة العمل، إذا + +546 +00:42:23,170 --> 00:42:24,810 +رأينا أن السعر هو 2500 + +547 +00:42:27,280 --> 00:42:31,280 +والدفع التجاري هو 350 مليون دولار تقريبًا تقريبًا + +548 +00:42:31,280 --> 00:42:34,380 +تقريبًا تقريبًا تقريبًا تقريبًا تقريبًا تقريبًا تقريبًا + +549 +00:42:34,380 --> 00:42:37,220 +تقريبًا تقريبًا تقريبًا تقريبًا تقريبًا تقريبًا تقريبًا + +550 +00:42:37,220 --> 00:42:37,340 +تقريبًا تقريبًا تقريبًا تقريبًا تقريبًا تقريبًا تقريبًا + +551 +00:42:37,340 --> 00:42:54,620 +تقريبًا تقريبًا تقريبًا تقريبًا تق + +552 +00:42:55,760 --> 00:42:59,080 +بالتالي فان جنرلت 0.14% من النار المستخدمة لكل + +553 +00:42:59,080 --> 00:43:04,060 +دولار مستخدم في السوق فتفكر + +554 +00:43:04,060 --> 00:43:12,300 +أنك عندما تتعامل مع مقارنة النار المستخدمة نحن + +555 +00:43:12,300 --> 00:43:20,460 +لدينا فاس 26% ثم نحن لدينا 14% ثم سنرى فهذا هو + +556 +00:43:20,460 --> 00:43:20,940 +مقارنة النار المستخدمة + +557 +00:43:25,800 --> 00:43:27,580 +مقارنة وهذه مقارنة التجارب التجريبية التجريبية + +558 +00:43:27,580 --> 00:43:29,600 +التجريبية التجريبية التجريبية التجريبية التجريبية + +559 +00:43:29,600 --> 00:43:30,600 +التجريبية التجريبية التجريبية التجريبية التجريبية + +560 +00:43:30,600 --> 00:43:31,780 +التجريبية التجريبية التجريبية التجريبية التجريبية + +561 +00:43:31,780 --> 00:43:32,320 +التجاربية التجاربية التجاربية التجاربية التجاربية + +562 +00:43:32,320 --> 00:43:34,460 +التجاربية التجاربية التجاربية التجاربية التجاربية + +563 +00:43:34,460 --> 00:43:36,140 +التجاربية التجاربية التجاربية التجاربية التجاربية + +564 +00:43:36,140 --> 00:43:36,520 +التجاربية التجاربية التجاربية التجاربية التجاربية + +565 +00:43:36,520 --> 00:43:40,700 +التجاربية + +566 +00:43:40,700 --> 00:43:44,080 +التجاربية + +567 +00:43:44,080 --> 00:43:54,060 +التجاربية التجاربية + +568 +00:43:54,060 --> 00:43:59,150 +التجOkay, but if we have problems in generating + +569 +00:43:59,150 --> 00:44:03,810 +gross, it means we may face challenges in the + +570 +00:44:03,810 --> 00:44:07,290 +operating expenses and paying interest and taxes + +571 +00:44:07,290 --> 00:44:10,710 +So this is the most important one + +572 +00:44:15,200 --> 00:44:19,600 +وأيضًا مشكلة مهمة، قيمة الأسعار التي تم تحفظها هي + +573 +00:44:19,600 --> 00:44:28,160 +أعلى قيمة في المشروع لأن المشروع يعتمد على هذا، + +574 +00:44:28,160 --> 00:44:31,840 +وفي الواضح أنه يعتمد على هذا في المشروع التصنيعي + +575 +00:44:31,840 --> 00:44:35,700 +الآن، + +576 +00:44:35,700 --> 00:44:38,640 +انظر إلى مجموعة النات بروفت متساومة بمجموعة النات + +577 +00:44:38,640 --> 00:44:40,340 +بروفِت متساومة + +578 +00:44:47,940 --> 00:44:58,020 +و 8.71 دولار يعني 1 دولار في السوق يجعل 8.71 دولار + +579 +00:44:58,020 --> 00:45:01,820 +أساساً أساساً 8.71 دولار في السوق يجعل 8.71 دولار + +580 +00:45:01,820 --> 00:45:06,180 +أساساً 8.71 دولار أساساً 8.71 دولار أساساً 8.71 + +581 +00:45:06,180 --> 00:45:07,160 +دولار أساساً 8.71 دولار أساساً 8.71 دولار أساساً 8 + +582 +00:45:07,160 --> 00:45:09,900 +.71 دولار أساساً 8.71 دولار أساساً 8.71 دولار + +583 +00:45:09,900 --> 00:45:13,060 +دولار أساساً 8.71 دولار أساساً 8.71 دولار أساساً 8 + +584 +00:45:13,060 --> 00:45:17,080 +.71 دولار أساساً 8.71 دولار أساساً 85% 5.30% + +585 +00:45:17,080 --> 00:45:29,820 +للأهداف والدفعات وهنا 12% يستخدمها لأسعار العمل أو + +586 +00:45:29,820 --> 00:45:39,880 +الأسعار العملية ونحن لدينا 74% لسعر الأسعار نقوم + +587 +00:45:39,880 --> 00:45:45,100 +باستخدام 2 أشياء في الوقت المناسب والسعر نقوم + +588 +00:45:45,100 --> 00:45:53,980 +باستخدام 2 أشياء في الوقت المناسب والآن + +589 +00:45:53,980 --> 00:45:59,620 +نتحدث عن .. فهل يوجد أسئلة مرتبطة مع مجموعة + +590 +00:45:59,620 --> 00:46:05,720 +الإنترنت؟ مجموعة الإنترنت والمجموعة العاملة؟ أي + +591 +00:46:05,720 --> 00:46:11,750 +أسئلة؟ حسناً دعونا نتحرك إلى المقارنة الأخرى للتفويت + +592 +00:46:11,750 --> 00:46:19,850 +وهذا يقوم بمقارنة إيجابية أساتذ في تجريم السالز أو + +593 +00:46:19,850 --> 00:46:28,790 +تجريم الأرباح تجريم التفويت على أساتذ تجريم + +594 +00:46:28,790 --> 00:46:34,350 +التفويت على أساتذ هذا يتم تخطيطه بمجموعة تجريم + +595 +00:46:34,350 --> 00:46:37,690 +التفويت على أساتذ تجريم تفويت على أساتذ تجريم + +596 +00:46:37,690 --> 00:46:37,730 +تفويت على أساتذ تجريم تفويت على أساتذ تجريم تفويت + +597 +00:46:37,730 --> 00:46:38,030 +على أساتذ تجريم تفويت على أساتذ تجريم تفويت على + +598 +00:46:38,030 --> 00:46:41,710 +تجريم تفوdivided by the total assets it means the + +599 +00:46:41,710 --> 00:46:44,590 +one dollar invested in total assets how much + +600 +00:46:44,590 --> 00:46:49,330 +generate as operating income okay or in other + +601 +00:46:49,330 --> 00:46:53,010 +words how many times the operating income covers + +602 +00:46:53,010 --> 00:46:56,810 +the total assets this is in other words let's see + +603 +00:46:56,810 --> 00:46:59,170 +the this here + +604 +00:47:09,620 --> 00:47:15,540 +ماذا غير صح؟ حسناً، فمجموعة نت الروحية هي نت + +605 +00:47:15,540 --> 00:47:19,520 +الإنقام مقاطعة السوق، أعتقد أننا نتحدث عن هذا + +606 +00:47:19,520 --> 00:47:28,060 +المجموعة تعمل على أساتذ، كما قلنا في الأسلحة + +607 +00:47:28,060 --> 00:47:31,800 +الأولى، هي مرتبطة بالتحكم في الأسعار والإيقاع في + +608 +00:47:31,800 --> 00:47:32,020 +الأسعار، + +609 +00:47:35,870 --> 00:47:40,570 +إذا الـ Operating Return on Assets هو مجموعة من + +610 +00:47:40,570 --> 00:47:45,070 +اثنين أشياء مجموعة من بعض الأشياء من الميزة التي + +611 +00:47:45,070 --> 00:47:49,470 +تقوم بمقارنة فعالية الروحانية أو مقارنة الروحانية + +612 +00:47:49,470 --> 00:47:54,550 +والتي تأتي من الـ Balance Sheet التي تقوم بمقارنة + +613 +00:47:54,550 --> 00:47:58,670 +فعالية الروحانية لذلك عندما نتحدث عن Operating + +614 +00:47:58,670 --> 00:48:01,530 +Return on Assets لدينا مقارنة الروحانية + +615 +00:48:04,610 --> 00:48:08,870 +والسعر المستفيد والمستفيدات والمستفيدات + +616 +00:48:08,870 --> 00:48:12,590 +والمستفيدات والمستفيدات والمستفيدات والمستفيدات + +617 +00:48:12,590 --> 00:48:17,150 +والمستفيدات والمستفيدات والمستفيدات والمستفيدات + +618 +00:48:17,150 --> 00:48:19,170 +والمستفيدات والمستفيدات والمستفيدات والمستفيدات + +619 +00:48:19,170 --> 00:48:21,370 +والمستفيدات والمستفيدات والمستفيدات والمستفيدات + +620 +00:48:21,370 --> 00:48:21,390 +والمستفيدات والمستفيدات والمستفيدات والمستفيدات + +621 +00:48:21,390 --> 00:48:21,430 +والمستفيدات والمستفيدات والمستفيدات والمستفيدات + +622 +00:48:21,430 --> 00:48:22,750 +والمستفيدات والمستفيدات والمستفيدات والمستفيدات + +623 +00:48:22,750 --> 00:48:27,620 +والمستفيدات والمستفيد مع المحافظة المحافظة المحافظة + +624 +00:48:27,620 --> 00:48:27,780 +المحافظة المحافظة المحافظة المحافظة المحافظة + +625 +00:48:27,780 --> 00:48:31,340 +المحافظة المحافظة المحافظة المحافظة المحافظة + +626 +00:48:31,340 --> 00:48:36,360 +المحافظة المحافظة المحافظة المحافظة المحافظة + +627 +00:48:36,360 --> 00:48:40,260 +المحافظة المحافظة المحافظة المحافظة + +628 +00:48:40,260 --> 00:48:40,800 +المحافظة المحافظة المحافظة المحافظة المحافظة + +629 +00:48:40,800 --> 00:48:40,860 +المحافظة المحافظة المحافظة المحافظة المحافظة + +630 +00:48:40,860 --> 00:48:48,380 +المحافظة المحافظة المح + +631 +00:48:48,440 --> 00:48:55,640 +إذا كان لديك الميزة العملية من الوصفة والميزة + +632 +00:48:55,640 --> 00:48:56,260 +العملية من الميزة العملية من الميزة العملية من + +633 +00:48:56,260 --> 00:48:57,040 +من الميزة العملية من الميزة العملية من الميزة + +634 +00:48:57,040 --> 00:48:58,460 +العملية من الميزة العملية من الميزة العملية من + +635 +00:48:58,460 --> 00:48:59,020 +الميزة العملية من الميزة العملية من الميزة العملية + +636 +00:48:59,020 --> 00:49:01,220 +من الميزة العملية من الميزة العملية من الميزة + +637 +00:49:01,220 --> 00:49:01,400 +العملية من الميزة العملية من الميزة العملية من + +638 +00:49:01,400 --> 00:49:02,060 +الميزة العملية من الميزة العملية من الميزة العملية + +639 +00:49:02,060 --> 00:49:02,700 +من الميزة العملية من الميزة العملية من الميزة + +640 +00:49:02,700 --> 00:49:07,580 +العملية من + +641 +00:49:07,580 --> 00:49:09,040 +الميزة + +642 +00:49:19,730 --> 00:49:25,470 +هو لديه عدد عملية أكثر على أساتيات أو عاملات أكثر + +643 +00:49:25,470 --> 00:49:31,030 +من الـ peer group كيف نتخيل هذا؟ كيف نحصل على الـ + +644 +00:49:31,030 --> 00:49:36,520 +19%؟ فقط اذهب للـreturn on asset is equal to + +645 +00:49:36,520 --> 00:49:39,400 +operating profit margin and I showed you how is + +646 +00:49:39,400 --> 00:49:43,780 +how we estimate this total asset turnover so sales + +647 +00:49:43,780 --> 00:49:47,040 +divided by total sales we have fourteen percent + +648 +00:49:47,040 --> 00:49:50,760 +times one point thirty seven and we have the same + +649 +00:49:50,760 --> 00:49:54,040 +okay + +650 +00:49:54,040 --> 00:50:00,100 +the + +651 +00:50:00,100 --> 00:50:01,140 +importance of + +652 +00:50:06,370 --> 00:50:12,510 +مهمة استعمال الـ Return on Assets هو كما قلنا إنها + +653 +00:50:12,510 --> 00:50:15,990 +تأثير على المعاملات السعية أو المعاملات التجاربية + +654 +00:50:15,990 --> 00:50:22,650 +ومعاملات الإيفيشنس أو استخدام الممارسة، لذلك من + +655 +00:50:22,650 --> 00:50:29,170 +المهم أن ننظر إلى كيف نقدر نقل المساعدة وكما ذكرنا + +656 +00:50:29,170 --> 00:50:33,590 +سابقاً عن الانفجار لأننا نلاحظ أن الانفجار مرتفع + +657 +00:50:33,590 --> 00:50:39,610 +في الـ Password لذلك يجب أن نفكر وكما ذكرنا عندما + +658 +00:50:39,610 --> 00:50:45,150 +أتكلم عن 74% إنه مرتفع لذلك يجب أن نفكر على قيم + +659 +00:50:45,150 --> 00:50:49,190 +السعيد الذي تم صنعه لذلك النتيجة هي أن الشركة يجب + +660 +00:50:49,190 --> 00:50:53,630 +أن تحقق قيم السعيد الذي تم صنعه وخدمات العمل لنرى + +661 +00:50:53,630 --> 00:51:00,380 +إذا كان هناك فرصة لتقسيم القيم ولكن عندما ألاحظ أنه + +662 +00:51:00,380 --> 00:51:08,120 +26% من الأسعار الزراعية ويعني أن المساعدة 74% بشكل + +663 +00:51:08,120 --> 00:51:13,260 +عام، لدينا مشكلة في أسعار الأسعار وهذا سيؤثر على + +664 +00:51:13,260 --> 00:51:20,090 +الترتيب على الأموال وهو واضح جداً ونختم الأشياء + +665 +00:51:20,090 --> 00:51:26,610 +الأخرى، عادة على المصادر لأن عامة أسعار السعوديين + +666 +00:51:26,610 --> 00:51:29,810 +لديها فرصة عامة عامة عامة عامة عامة عامة عامة عامة + +667 +00:51:29,810 --> 00:51:30,030 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +668 +00:51:30,030 --> 00:51:30,230 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +669 +00:51:30,230 --> 00:51:31,030 +عامة عامة عامة + +670 +00:51:37,230 --> 00:51:41,170 +هذه محاولات التحقيق لتحقيق مستخدم التحقيق على + +671 +00:51:41,170 --> 00:51:44,550 +مستخدم الأسعار لديك مصادر مستخدم مستخدم مستخدم + +672 +00:51:44,550 --> 00:51:45,110 +مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم + +673 +00:51:45,110 --> 00:51:45,270 +مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم + +674 +00:51:45,270 --> 00:51:45,790 +مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم + +675 +00:51:45,790 --> 00:51:49,190 +مستخدم مستخدم مستخدم مستخدم + +676 +00:51:49,190 --> 00:51:56,720 +مستخدم مستخدم الـ Return on Assets لأنك لديك الـ + +677 +00:51:56,720 --> 00:52:00,800 +Total Assets تفضل هذه التخطيطات الـ Operating + +678 +00:52:00,800 --> 00:52:03,740 +Return on Assets لديك الـ Operating Profit Margin + +679 +00:52:03,740 --> 00:52:05,200 +مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة + +680 +00:52:05,200 --> 00:52:05,580 +مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة + +681 +00:52:05,580 --> 00:52:06,500 +مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة + +682 +00:52:06,500 --> 00:52:07,380 +مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة + +683 +00:52:07,380 --> 00:52:10,140 +مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة + +684 +00:52:10,140 --> 00:52:10,380 +مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة + +685 +00:52:10,380 --> 00:52:10,700 +مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة + +686 +00:52:10,700 --> 00:52:18,240 +مرة مرة مرة مرة + +687 +00:52:26,480 --> 00:52:37,040 +تأخذ واحد دقيقة لتحقق النتائج إعادة + +688 +00:52:37,040 --> 00:52:42,000 +العمل + +689 +00:52:42,000 --> 00:52:53,280 +هي 18% 18.55% 10.65 10.98 1.74 1.60 27 + +690 +00:52:57,610 --> 00:53:11,590 +4.76 2.95 لنبدأ + +691 +00:53:11,590 --> 00:53:12,310 +بالأول + +692 +00:53:14,930 --> 00:53:20,330 +العادة العملية على الأساتيات هي 18.51% في الـ Home + +693 +00:53:20,330 --> 00:53:25,890 +Depot 2007 بالمقارنة بلويس هي 18.55% ماذا تعتقدين + +694 +00:53:25,890 --> 00:53:33,130 +عن هذا؟ الثاني، لكن ليس هناك اختلاف مهم بينهم، نعم + +695 +00:53:33,130 --> 00:53:38,410 +أنت محق، نحن نفضل الثاني، ولكن لا اختلاف مهم بين + +696 +00:53:38,410 --> 00:53:43,880 +الأول والثاني، حسناً؟ انظروا إلى الشخص الثاني يعمل + +697 +00:53:43,880 --> 00:53:52,980 +مقارنة الروحانية 10.65% و 10.98% فماذا تعتقد؟ خلود + +698 +00:53:52,980 --> 00:53:58,740 +ماذا تعتقد؟ هل + +699 +00:53:58,740 --> 00:54:06,490 +تعتقد أن هناك اختلاف كبير بينهم؟ لا لا اختلاف Okay, + +700 +00:54:06,510 --> 00:54:14,110 +total asset turnover is 1.74 and 1.69 what it + +701 +00:54:14,110 --> 00:54:18,310 +means this? it means the assets generating more + +702 +00:54:18,310 --> 00:54:23,130 +sales than the second one which means they have + +703 +00:54:23,130 --> 00:54:27,190 +more efficiency in terms of managing the assets + +704 +00:54:27,190 --> 00:54:32,770 +but still the 1.74 is not that big difference + +705 +00:54:32,770 --> 00:54:37,000 +between them الآن انظر إلى الـ account receivable + +706 +00:54:37,000 --> 00:54:43,560 +turnover نحن لدينا 27 و 291 أعتقد أن هناك شيء خاطئ + +707 +00:54:43,560 --> 00:54:50,320 +مع الـ 291 يعني أنه كل 2 أيام أو كل يوم ونصف + +708 +00:54:50,320 --> 00:54:56,100 +يقومون بتحويل الـ account receivable إلى cash يجب + +709 +00:54:56,100 --> 00:54:59,160 +أن نفكر مرتين في هذا الموضوع الـ Inventory + +710 +00:54:59,160 --> 00:55:01,680 +turnover ماذا تفكر؟ + +711 +00:55:09,220 --> 00:55:18,140 +الأولى ما زالت لا اختلاف كبير 4.76 و 4.30 أكثر + +712 +00:55:18,140 --> 00:55:19,200 +أكثر أكثر أكثر أكثر أكثر أكثر أكثر أكثر أكثر أكثر + +713 +00:55:19,200 --> 00:55:19,240 +أكثر أكثر أكثر أكثر أكثر أكثر أكثر أكثر أكثر أكثر + +714 +00:55:19,240 --> 00:55:19,720 +أكثر أكثر أكثر أكثر أكثر أكثر أكثر أكثر أكثر أكثر + +715 +00:55:19,720 --> 00:55:20,800 +أكثر أكثر أكثر أكثر أكثر أكثر أكثر أكثر أكثر أكثر + +716 +00:55:20,800 --> 00:55:27,260 +أكثر أكثر أكثر أكثر أكثر أكثر أكثر أكثر أكثر + +717 +00:55:27,260 --> 00:55:30,590 +استخدام الواحدة لأنها استخدام واحدة مستقل تتحول + +718 +00:55:30,590 --> 00:55:32,070 +إلى واحدة مستقل تتحول إلى واحدة مستقل تتحول إلى + +719 +00:55:32,070 --> 00:55:33,450 +واحدة مستقل تتحول إلى واحدة مستقل تتحول إلى واحدة + +720 +00:55:33,450 --> 00:55:36,050 +مستقل تتحول إلى واحدة مستقل تتحول إلى واحدة مستقل + +721 +00:55:36,050 --> 00:55:39,690 +تتحول إلى واحدة + +722 +00:55:39,690 --> 00:55:42,670 +مستقل تتحول إلى واحدة مستقل تتحول إلى واحدة مستقل + +723 +00:55:42,670 --> 00:55:45,830 +تتحول إلى واحدة مستقل تتحول إلى واحدة مستقل تتحول + +724 +00:55:45,830 --> 00:55:47,190 +إلى واحدة مستقل تتحول إلى واحدة مستقل تتحول إلى + +725 +00:55:47,190 --> 00:55:51,850 +واحدة مستقل تتحول إلى واحدة مستقل تتحول إلى واحدة + +726 +00:55:55,220 --> 00:55:56,380 +هي عملية عملية عملية عملية عملية عملية عملية عملية + +727 +00:55:56,380 --> 00:55:57,660 +عملية عملية عملية عملية عملية عملية عملية عملية + +728 +00:55:57,660 --> 00:55:58,780 +عملية عملية عملية عملية عملية عملية عملية عملية + +729 +00:55:58,780 --> 00:55:58,940 +عملية عملية عملية عملية عملية عملية عملية عملية + +730 +00:55:58,940 --> 00:56:01,320 +عملية عملية عملية عملية عملية عملية عملية عملية + +731 +00:56:01,320 --> 00:56:01,860 +عملية عملية عملية عملية عملية عملية عملية عملية + +732 +00:56:01,860 --> 00:56:06,400 +عملية عملية عملية عملية عملية عملية عملية عملية + +733 +00:56:06,400 --> 00:56:06,560 +عملية عملية عملية عملية عملية عملية عملية عملية + +734 +00:56:06,560 --> 00:56:08,580 +عملية عملية + +735 +00:56:12,600 --> 00:56:17,100 +للاستماع لهذا، نستخدم ثلاث مقارنة، واحد، اثنان، + +736 +00:56:17,100 --> 00:56:22,500 +وثلاثة. الأول هو مقارنة التفويت، والثاني هو مقارنة + +737 +00:56:22,500 --> 00:56:29,180 +التفويت والثالث هو المزيد من الميزة. نتحدث عن + +738 +00:56:29,180 --> 00:56:34,080 +مقارنة التفويت، نتحدث عن مقارنة التفويت، ولكن الآن + +739 +00:56:34,080 --> 00:56:40,580 +مقارنة الميزة. ما يعني مقارنة الميزة، نعم، one + +740 +00:56:40,580 --> 00:56:42,900 +divided by one minus the debt ratios. + +741 +00:56:46,620 --> 00:56:49,820 +فهو one divided by one minus the debt ratios. + +742 +00:56:53,000 --> 00:56:58,600 +ودفع دفع الدفع الدفع دفع دفع دفع دفع دفع دفع دفع + +743 +00:56:58,600 --> 00:56:58,620 +دفع دفع دفع دفع دفع دفع دفع دفع دفع دفع دفع + +744 +00:56:58,620 --> 00:56:59,400 +دفع دفع دفع دفع دفع دفع دفع دفع دفع دفع دفع + +745 +00:56:59,400 --> 00:57:05,560 +دفع دفع دفع دفع دفع دفع دفع + +746 +00:57:05,560 --> 01:00:14,440 +Okay, total liabilities and equity Okay, + +747 +00:57:14,900 --> 00:57:20,860 +so now this is the equity multiplier The more debt + +748 +00:57:20,860 --> 00:57:24,940 +ratios that we have The more debt ratios that we + +749 +00:57:24,940 --> 00:57:29,400 +have The higher the equity multipliers or the more + +750 +00:57:29,400 --> 00:57:34,160 +equity multipliers For instance, if the debt ratio + +751 +00:57:34,160 --> 00:57:34,920 +is zero + +752 +00:57:38,450 --> 00:57:42,150 +الـ debt ratio هو نصف، هذا يعني أننا لدينا واحدة + +753 +00:57:42,150 --> 00:57:47,630 +اقتصادية بدأت من واحدة و + +754 +00:57:47,630 --> 00:57:57,770 +أكثر الـ debts اللي لدينا أكثر الـ debts اللي لدينا أكثر + +755 +00:57:57,770 --> 00:58:01,050 +ABS أو فان فاليو + +756 +00:58:10,100 --> 00:58:17,780 +على سبيل المثال، لتحفز قيمة الشركة، يتم تحفيز أو + +757 +00:58:17,780 --> 00:58:24,460 +تزيد قيمة الوظيفة وقد شرحت هذا في تحفيز الوظيفة + +758 +00:58:24,460 --> 00:58:32,240 +عندما نتحدث عن مقاومة الوظيفة نحن + +759 +00:58:32,240 --> 00:58:36,500 +نتحدث عن .. مقاومة الوظيفة هي مثل هذه، لدينا مصدر + +760 +00:58:37,730 --> 00:58:44,150 +وهنا لدينا كتابة لتضغط هذه الكتابة إذا كانت هذه + +761 +00:58:44,150 --> 00:58:52,470 +كتابة تقارن مع هذه كتابة + +762 +00:58:52,470 --> 00:58:55,570 +حسب + +763 +00:58:55,570 --> 00:59:02,960 +الفيزياء في الفيزياء إذا قمنا بتضغط هذه الكتابة هذا + +764 +00:59:02,960 --> 00:59:08,980 +الوضع سيكون أقوى من هذا لأنه أكثر من هذا لذلك الـD + +765 +00:59:08,980 --> 00:59:19,100 +الوضع أكثر من الوضع هنا تعتبر الـD هنا مقالات و + +766 +00:59:19,100 --> 00:59:24,880 +تعتبر الـEBS نفس الـEBS هنا و الـEBS أيضًا نفس الـEBS هنا + +767 +00:59:24,880 --> 00:59:31,850 +نفس الـEBS هنا لذلك القوة هي الـEBS المزيد من الفرق + +768 +00:59:31,850 --> 00:59:35,530 +اللي لدينا، المزيد من الفرق اللي لدينا، المزيد من + +769 +00:59:35,530 --> 00:59:35,550 +الفرق اللي لدينا، المزيد من الفرق اللي لدينا، + +770 +00:59:35,550 --> 00:59:36,090 +المزيد من الفرق اللي لدينا، المزيد من الفرق اللي + +771 +00:59:36,090 --> 00:59:36,150 +لدينا، المزيد من الفرق اللي لدينا، المزيد من الفرق + +772 +00:59:36,150 --> 00:59:36,190 +الفرق اللي لدينا، المزيد من الفرق اللي لدينا، + +773 +00:59:36,190 --> 00:59:36,810 +المزيد من الفرق اللي لدينا، المزيد من الفرق اللي + +774 +00:59:36,810 --> 00:59:38,790 +لدينا، المزيد من الفرق اللي لدينا، المزيد من الفرق + +775 +00:59:38,790 --> 00:59:43,170 +اللي لدينا، المزيد + +776 +00:59:43,170 --> 00:59:46,870 +من الفرق اللي لدينا، المزيد + +777 +00:59:46,870 --> 00:59:51,230 +من الفرق + +778 +00:59:51,230 --> 00:59:53,790 +اللي لدينا، المزيد + +779 +00:59:57,510 --> 01:00:01,830 +في شركة A نحن نحن نحن نحن نحن نحن نحن نحن نحن + +780 +01:00:01,830 --> 01:00:02,850 +نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن + +781 +01:00:02,850 --> 01:00:04,130 +نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن + +782 +01:00:04,130 --> 01:00:07,050 +نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن + +783 +01:00:07,050 --> 01:00:07,290 +نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن + +784 +01:00:07,290 --> 01:00:08,770 +نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن + +785 +01:00:08,770 --> 01:00:15,210 +نحن نحن + +786 +01:00:15,210 --> 01:00:21,200 +نحن أو 700 and the debt the equity is 300 so we + +787 +01:00:21,200 --> 01:00:25,500 +have one million here we have 300 and 700 now + +788 +01:00:25,500 --> 01:00:30,300 +consider this case the profits the + +789 +01:00:30,300 --> 01:00:35,880 +profit is let's say one hundred dollar and here + +790 +01:00:35,880 --> 01:00:39,360 +one hundred dollar الآن دعونا نقوم بتخطيط الـ EBS + +791 +01:00:39,360 --> 01:00:45,320 +لكثير الـ EBS يتم تخطيطه كـ Net Income Divided By + +792 +01:00:45,320 --> 01:00:48,980 +The Number Of Shares Outstanding Now ما هي الـ net + +793 +01:00:48,980 --> 01:00:53,260 +income هنا هو 100 number of shares outstanding إذا + +794 +01:00:53,260 --> 01:01:01,200 +كان هذا قيمة أعلى هو 300 وهنا 100 مقابل 700 ما هي + +795 +01:01:01,200 --> 01:01:10,500 +الـ EBS هنا هو 33% الـ EBS هنا 14% So in this case + +796 +01:01:10,500 --> 01:01:17,300 +the profit is the same but what is the .. the + +797 +01:01:17,300 --> 01:01:20,000 +difference is the capital structure وهي we depend + +798 +01:01:20,000 --> 01:01:23,560 +on more debts So what is the result? We end with + +799 +01:01:23,560 --> 01:01:31,020 +33 percent as ABS وهنا 14% كـ EBS إذا دفعنا 1 دولار + +800 +01:01:31,020 --> 01:01:36,640 +في هذه الشركة سنحصل على 33 سنة ولكن إذا دفعنا 1 + +801 +01:01:36,640 --> 01:01:43,300 +دولار هنا سنحصل على 14 سنة فهو + +802 +01:01:43,300 --> 01:01:49,420 +حسن للدفع لـ A لأننا قمنا بمعالجة الـ EBS أو قمنا + +803 +01:01:49,420 --> 01:01:55,000 +بمعالجة قيمة الـ FAM لماذا؟ لأن الـ debt هذا السبب أنه + +804 +01:01:55,000 --> 01:01:59,820 +مهم أن تضمن المال المعادل المعادل التي تعتبر المال + +805 +01:01:59,820 --> 01:02:03,000 +حسنا + +806 +01:02:03,000 --> 01:02:08,440 +فهذا هو السبب وأكثر ما نعتمد على المال أكثر ما + +807 +01:02:08,440 --> 01:02:15,060 +نحفزه حسنا دعونا نذهب هكذا اتغيرت هذه الوضعية بفعل + +808 +01:02:15,060 --> 01:02:23,200 +حسنا 100 مال و900 مال لدينا 100 هنا + +809 +01:02:26,110 --> 01:02:32,710 +لذلك نحصل على 100% من الأرباح، لذلك إذا كنت قمت + +810 +01:02:32,710 --> 01:02:35,930 +ببيع واحد دولار، فنحصل على واحد دولار، لكن + +811 +01:02:35,930 --> 01:02:41,050 +الأرباح مازالت نفسها، لا تغيير في الأرباح، لكن + +812 +01:02:41,050 --> 01:02:47,030 +المشكلة بهذا أنها تحفز الأرباح وتحفز الفوز، إنها + +813 +01:02:47,030 --> 01:02:49,690 +تحافظ على ترتيب أعلى وفي نفس الوقت تحافظ على أعلى + +814 +01:02:49,690 --> 01:02:57,810 +أسرار، إذا كنا نخسر 100$ لذلك فالفكرة ستتغير، لذلك + +815 +01:02:57,810 --> 01:03:03,850 +نخسر هنا 100 أو 1 دولار ونخسر فقط 13 أو 14 سنة، + +816 +01:03:03,850 --> 01:03:11,170 +لذلك نفضل B على A بسبب مصطلح الكفة، حسنا؟ + +817 +01:03:14,040 --> 01:03:17,320 +هو كيف نقوم بالتخطيط للحصول على حصولة عملية عامة + +818 +01:03:17,320 --> 01:03:22,940 +بقية السعوانات ونقوم بالتحديث + +819 +01:03:22,940 --> 01:03:31,810 +عن نتيجة السعوانات الـ 22% هو الوصول من مرة 2.16 + +820 +01:03:31,810 --> 01:03:38,670 +مرة 1.37 مرة 7.6% نحن لدينا 22% بالمقارنة بالجماعة + +821 +01:03:38,670 --> 01:03:45,110 +العامة، شركة PassWell لديها إرجاع أعلى على المال + +822 +01:03:45,110 --> 01:03:51,150 +لماذا؟ لأن الـ Net Profits إذا نظرنا إلى المجموعات + +823 +01:03:51,150 --> 01:03:56,760 +المجتمعة هي أعلى استخدام السوق يكون أعلى من هذا، + +824 +01:03:56,760 --> 01:03:59,840 +ولكن مجموعة الناتس بروفت أقل من هذا، ولكن المشكلة + +825 +01:03:59,840 --> 01:04:04,260 +هي أن الـ equity multiplier يقوم بإعادة قيمة + +826 +01:04:04,260 --> 01:04:05,820 +الشركة، إعادة الاستثمار بالاستثمار بالاستثمار + +827 +01:04:05,820 --> 01:04:09,280 +بالاستثمار بالاستثمار بالاستثمار بالاستثمار + +828 +01:04:09,280 --> 01:04:10,400 +بالاستثمار بالاستثمار بالاستثمار بالاستثمار + +829 +01:04:10,400 --> 01:04:10,480 +بالاستثمار بالاستثمار بالاستثمار بالاستثمار + +830 +01:04:10,480 --> 01:04:11,100 +بالاستثمار بالاستثمار بالاستثمار بالاستثمار + +831 +01:04:11,100 --> 01:04:11,260 +بالاستثمار بالاستثمار بالاستثمار بالاستثمار + +832 +01:04:11,260 --> 01:04:14,800 +بالاستثمار بالاستثمار بالاستثمار بالا + +833 +01:04:17,300 --> 01:04:19,960 +Okay we stop here to talk about the market value + +834 +01:04:19,960 --> 01:04:25,240 +ratios next meeting okay this is the last one or + +835 +01:04:25,240 --> 01:04:28,740 +the last meeting in the chapter four okay + +836 +01:04:28,740 --> 01:04:30,720 +إن شاء الله see you إن شاء الله on Wednesday diff --git a/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/Dp9dBSqc0t8_postprocess.srt b/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/Dp9dBSqc0t8_postprocess.srt new file mode 100644 index 0000000000000000000000000000000000000000..96e21ac77020194d8e8bc2f5b10c17035f5a6ef4 --- /dev/null +++ b/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/Dp9dBSqc0t8_postprocess.srt @@ -0,0 +1,3344 @@ +1 +00:00:20,750 --> 00:00:24,870 +بسم الله الرحمن الرحيم أول شي نحكيلكوا كل عام طوب + +2 +00:00:24,870 --> 00:00:31,210 +خير مناسبة عيد القطح المبارك وإن شاء الله يعني + +3 +00:00:31,210 --> 00:00:34,210 +ربنا سبحانه و تعالى يعيدوا علينا بالخير وعلى الأمة + +4 +00:00:34,210 --> 00:00:37,030 +الإسلامية إن شاء الله و الأمة العربية وكل الشعوب + +5 +00:00:37,030 --> 00:00:42,590 +العالم إن شاء الله المرة الفاتة كنا نحكي بال + +6 +00:00:42,590 --> 00:00:47,330 +liquidity management or liquidity ratios and we + +7 +00:00:47,330 --> 00:00:51,270 +categorized liquidityإلى عملية الميزة العامة + +8 +00:00:51,270 --> 00:00:54,330 +ومجموعات + +9 +00:00:54,330 --> 00:00:57,990 +الميزة الوحيدة لذلك نقوم بمقارنة الميزة عامة بشكل + +10 +00:00:57,990 --> 00:01:03,790 +عام ونقوم بمقارنة الميزة عامة لكل أجهزة في الميزة + +11 +00:01:03,790 --> 00:01:06,790 +الحالية بشكل + +12 +00:01:06,790 --> 00:01:09,970 +عام مقارنة الميزة عامة بشكل عام بشكل عام بشكل عام + +13 +00:01:09,970 --> 00:01:14,750 +بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل + +14 +00:01:14,750 --> 00:01:15,590 +عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام + +15 +00:01:15,590 --> 00:01:15,710 +بشكل عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل + +16 +00:01:15,710 --> 00:01:17,410 +عام بشكل عام بشكل عام بشكل عام بشكل عام بشكل ع + +17 +00:01:17,450 --> 00:01:23,770 +مقارنة الأسعار ونقول أن مقارنة الأسعار هي أكتر أو + +18 +00:01:23,770 --> 00:01:29,230 +أهم من المقارنة الحقيقية الآن سنتحدث عن مقارنة + +19 +00:01:29,230 --> 00:01:34,710 +الأسعار بالنسبة لجمهور أسعار الأسعار الخاصة سنرى + +20 +00:01:34,710 --> 00:01:39,750 +مقارنة الأسعار أو مقارنة الأسعار التي يمكن تحقيقها + +21 +00:01:39,750 --> 00:01:46,590 +ومقارنة الأسعار التي تحقيقهاالهم من هذه الاثنين .. + +22 +00:01:46,590 --> 00:01:49,550 +الاسماء الاسماء الاسماء الاسماء الاسماء الاسماء + +23 +00:01:49,550 --> 00:01:50,870 +الاسماء الاسماء الاسماء الاسماء الاسماء الاسماء + +24 +00:01:50,870 --> 00:01:53,850 +الاسماء الاسماء الاسماء الاسماء الاسماء الاسماء + +25 +00:01:53,850 --> 00:01:56,310 +الاسماء الاسماء الاسماء الاسماء الاسماء الاسماء + +26 +00:01:56,310 --> 00:01:59,530 +الاسماء الاسماء الاسماء الاسماء الاسماء الاسماء + +27 +00:01:59,530 --> 00:02:10,970 +الاسماء الاسماء الاسماء الاسماء الاسماء الاس + +28 +00:02:11,390 --> 00:02:15,570 +عن كم وقت تستخدمها لتحويل المصادر المستقبلية إلى + +29 +00:02:15,570 --> 00:02:20,970 +المال بمعنى كم مرات نستطيع تحويل المصادر + +30 +00:02:20,970 --> 00:02:25,670 +المستقبلية إلى المال في عام والشيء نفسه عندما + +31 +00:02:25,670 --> 00:02:29,610 +نتحدث عن المصادر كم وقت يستخدمها لتحويل المصادر + +32 +00:02:29,610 --> 00:02:31,810 +إلى المال هذا المهم + +33 +00:02:36,680 --> 00:02:40,440 +الحصة المستخدمة مقومة بمقارنة عامة تجارب التجارب + +34 +00:02:40,440 --> 00:02:44,620 +كم ساعة تستخدمها لتحويل الحصة المستخدمة إلى المال + +35 +00:02:44,620 --> 00:02:48,240 +نقل الحصة المستخدمة للحصة المستخدمة للحصة + +36 +00:02:48,240 --> 00:02:48,380 +المستخدمة للحصة المستخدمة للحصة المستخدمة للحصة + +37 +00:02:48,380 --> 00:02:52,440 +المستخدمة للحصة المستخدمة للحصة المستخدمة للحصة + +38 +00:02:52,440 --> 00:02:56,420 +المستخدمة للحصة المستخدمة للحصة المستخدمة للحصة + +39 +00:02:56,420 --> 00:02:56,640 +المستخدمة للحصة المستخدمة للحصة المستخدمة للحصة + +40 +00:02:56,640 --> 00:02:59,220 +المستخدمة للحصة المستخدمة للحصة المستخدمة للحصة + +41 +00:02:59,220 --> 00:03:04,260 +المستخدمة للحصة + +42 +00:03:08,390 --> 00:03:12,750 +لذلك إذا كان لدينا يومين أفضل من يكون لدينا يومين + +43 +00:03:12,750 --> 00:03:16,330 +أكبر، دعونا .. على سبيل المثال إذا عمر التجارب + +44 +00:03:16,330 --> 00:03:20,230 +العادل عمر + +45 +00:03:20,230 --> 00:03:23,270 +التجارب عمر التجارب عمر تجارب عمر تجارب عمر تجارب + +46 +00:03:23,270 --> 00:03:25,110 +عمر تجارب عمر تجارب عمر تجارب عمر تجارب عمر تجارب + +47 +00:03:25,110 --> 00:03:27,230 +عمر تجارب عمر تجارب عمر تجارب عمر تجارب عمر تجارب + +48 +00:03:27,230 --> 00:03:29,230 +عمر تجارب عمر تجارب عمر تجارب عمر تجارب عمر تجارب + +49 +00:03:29,230 --> 00:03:32,910 +عمر تجارب عمر تجارب عمر + +50 +00:03:32,910 --> 00:03:37,390 +تجارب عمر + +51 +00:03:37,390 --> 00:03:37,470 +تج + +52 +00:03:40,630 --> 00:03:46,270 +collecting periods which is indicate company A may + +53 +00:03:46,270 --> 00:03:53,470 +have more liquidity than company B okay some in + +54 +00:03:53,470 --> 00:03:58,050 +some cases people calculate the account receivable + +55 +00:03:58,050 --> 00:04:02,630 +by the account receivable turnover instead of + +56 +00:04:02,630 --> 00:04:05,250 +using average collection periods they are using + +57 +00:04:05,250 --> 00:04:08,410 +account + +58 +00:04:08,410 --> 00:04:10,010 +receivable turnover + +59 +00:04:12,430 --> 00:04:15,230 +كيف يفعلون هذا هو انهم يقومون بتقليل المستخدم + +60 +00:04:15,230 --> 00:04:20,250 +المستخدم المستخدم + +61 +00:04:20,250 --> 00:04:28,110 +المستخدم المستخدم المستخدم المستخدم المستخدم + +62 +00:04:28,110 --> 00:04:31,090 +المستخدم المستخدم المستخدم المستخدم المستخدم + +63 +00:04:31,090 --> 00:04:34,670 +المستخدم المستخدم المستخدم المستخدم المستخدم + +64 +00:04:34,670 --> 00:04:36,750 +المستخدم المستخدم المستخدم المستخدم المستخدم + +65 +00:04:36,750 --> 00:04:37,070 +المستخدم المستخدم المستخدم المستخدم المستخدم + +66 +00:04:37,070 --> 00:04:41,650 +المستخدم المستخدم المستخدم المستخدم المستخدم + +67 +00:04:41,650 --> 00:04:41,770 +المستخدم المستخدم المستخدم المستخدم المستخدم + +68 +00:04:41,770 --> 00:04:44,150 +المستخدم المستخدم المستخدم المستالنتائج ستكون في + +69 +00:04:44,150 --> 00:04:49,850 +الوقت المناسب لذلك باعتبار هذا الواقع المستقبلي كم + +70 +00:04:49,850 --> 00:04:58,890 +مرة تحول الشركة الواقع المستقبلي إلى المالونتوقع + +71 +00:04:58,890 --> 00:05:02,750 +أن الشركة تكون لديها زيارة أكتر من الشركة الأخرى + +72 +00:05:02,750 --> 00:05:07,110 +على سبيل المثال إذا ما زالت لدينا شركة A وشركة B + +73 +00:05:07,110 --> 00:05:15,990 +إذا كانت شركة A لديها ثلاثة مرات وشركة + +74 +00:05:15,990 --> 00:05:28,160 +B لديها 15 مرات يعني أن هذا Ait takes 13 times to + +75 +00:05:28,160 --> 00:05:31,360 +convert asset into cash so if you convert this + +76 +00:05:31,360 --> 00:05:36,800 +into days you just need to do 360 divided by 30 + +77 +00:05:36,800 --> 00:05:40,500 +times you get the number of days you can do it in + +78 +00:05:40,500 --> 00:05:44,580 +different ways لو + +79 +00:05:44,580 --> 00:05:47,260 +this is 30 times a year + +80 +00:05:50,260 --> 00:05:55,680 +تقوم بتحويل المصادر المستقبلية إلى المال 30 مرتين + +81 +00:05:55,680 --> 00:06:04,460 +في السنة الآن أنا أسألك ماذا؟ 30 او 15؟ 30 مرات هو + +82 +00:06:04,460 --> 00:06:08,980 +أكتر من 15 مرات حسنًا + +83 +00:06:08,980 --> 00:06:12,420 +هذا + +84 +00:06:12,420 --> 00:06:16,040 +هو طريقة تخطيط مصادر المال اليومي 2500 مليون مليون + +85 +00:06:16,040 --> 00:06:19,070 +مليون مليون مليون مليون مليون مليون مليونaccount + +86 +00:06:19,070 --> 00:06:22,110 +receivable divided by credits daily credit sales + +87 +00:06:22,110 --> 00:06:25,270 +so this is the account receivable divided by daily + +88 +00:06:25,270 --> 00:06:30,430 +credit sales you have 20 days so it takes 20 days + +89 +00:06:30,430 --> 00:06:34,950 +to convert the account receivable into cash you + +90 +00:06:34,950 --> 00:06:38,190 +can compare this with the peer group or with the + +91 +00:06:38,190 --> 00:06:45,390 +industrial level and then judge on this resultوهذا + +92 +00:06:45,390 --> 00:06:48,190 +الـ account receivable turned over وهذا مخصص على + +93 +00:06:48,190 --> 00:06:54,490 +الوقت وهذا مخصص على عدد الأيام وهذا مخصص على الوقت + +94 +00:06:54,490 --> 00:06:59,550 +ومجدداً يعني شركات دفعات عامة مختلفة من الـ + +95 +00:06:59,550 --> 00:07:07,650 +account receivable ونتيجة في الوقت 17 مرات تأخذ كل + +96 +00:07:07,650 --> 00:07:13,950 +ال .. ال .. ال account receivableهو مقفل 17 مرات + +97 +00:07:13,950 --> 00:07:24,210 +أو مقفل 17 مرات في العمل في العمل + +98 +00:07:24,210 --> 00:07:24,650 +في العمل في العمل في العمل في العمل في العمل في + +99 +00:07:24,650 --> 00:07:24,890 +في العمل في العمل في العمل في العمل في العمل في + +100 +00:07:24,890 --> 00:07:25,050 +في العمل في العمل في العمل في العمل في العمل في + +101 +00:07:25,050 --> 00:07:25,130 +العمل في العمل في العمل في العمل في العمل في العمل + +102 +00:07:25,130 --> 00:07:25,190 +في العمل في العمل في العمل في العمل في العمل في + +103 +00:07:25,190 --> 00:07:27,050 +في العمل في العمل في العمل في العمل في العمل في + +104 +00:07:27,050 --> 00:07:39,870 +العمل في العمل في العمل في العمل في العمل في العمل + +105 +00:07:39,870 --> 00:07:48,500 +فيوانتقل لتعريف المال ومقالات شركة Aswell لديك + +106 +00:07:48,500 --> 00:07:58,520 +قيمة الأسعار 1980 مقالة 229 مقالات لديك 8.63 مرات + +107 +00:07:58,520 --> 00:08:04,640 +هذا يعني أننا عملنا تغيير المصادر إلى المال 8.63 + +108 +00:08:04,640 --> 00:08:09,880 +مرات في السنة إذا أردت تغييرها إلى أيام فتفعل 360 + +109 +00:08:09,880 --> 00:08:22,360 +أو 65 مراتمع 8.63 تحصل على عدد الأيام ونتوقع + +110 +00:08:22,360 --> 00:08:27,600 +أن أعلى عدد الانتجار التي يتم تحويله يكون أفضل أو + +111 +00:08:27,600 --> 00:08:35,860 +يكون أفضل بالنسبة للعملفي peer group peer group is + +112 +00:08:35,860 --> 00:08:39,160 +like you compare yourself with the industry or + +113 +00:08:39,160 --> 00:08:42,880 +with the competitors زي معظم؟ معظم؟ yes يعني احنا + +114 +00:08:42,880 --> 00:08:48,220 +مش بنحسبوش؟ no this is your competitors the peer + +115 +00:08:48,220 --> 00:08:52,480 +group is your competitors you comparing this 8.63 + +116 +00:08:52,480 --> 00:08:59,890 +for instance this 8.63 with the peer groupوالـ + +117 +00:08:59,890 --> 00:09:04,970 +Inventory هي 8.63 مرات وإذا كانت الـ peer group 9 + +118 +00:09:04,970 --> 00:09:09,910 +أو 11، فهذا يعني أننا لدينا مشاكل في الـ Inventory + +119 +00:09:09,910 --> 00:09:15,070 +لأن الـ peer group أعلى في الوقت اللي يقوم بتحويل + +120 +00:09:15,070 --> 00:09:21,210 +الـ Inventory إلى الـ Cash من شركة PassWellسنعود + +121 +00:09:21,210 --> 00:09:27,310 +في التفاصيل عن الـ Inventory turnover عندما نتحدث + +122 +00:09:27,310 --> 00:09:33,750 +عن تسريح الأسعار أو عملية تسريح الأسعار بالنسبة + +123 +00:09:33,750 --> 00:09:42,150 +لعدد الأيام كما فعلت 365×8.63 لذلك يحتاج إلى 42 + +124 +00:09:42,150 --> 00:09:45,870 +أيام لتغيير الـ Inventory إلى الـ Cash لذلك + +125 +00:09:45,870 --> 00:09:47,310 +السيكلة تتحرك مثل هذا + +126 +00:09:52,380 --> 00:09:59,060 +هذا هو الانفجار ثم + +127 +00:09:59,060 --> 00:10:05,260 +نقوم بتحويل الانفجار إلى السوق ثم السوق إلى المال + +128 +00:10:05,260 --> 00:10:08,960 +لذلك + +129 +00:10:08,960 --> 00:10:15,440 +يستغرق حوالي 42 أيام لتحويل الانفجار إلى المال وقت + +130 +00:10:15,440 --> 00:10:18,360 +هذا حوالي 42 أيام + +131 +00:10:21,410 --> 00:10:28,790 +Okay, so around one month and a half for + +132 +00:10:28,790 --> 00:10:36,370 +the two days Can + +133 +00:10:36,370 --> 00:10:40,450 +a firm have too much liquidity? Yes, is good for + +134 +00:10:40,450 --> 00:10:44,030 +business having too much liquidity? No, why not? + +135 +00:10:46,530 --> 00:10:49,270 +Yes, because they are missing the opportunity for + +136 +00:10:49,270 --> 00:10:55,080 +investmentالسؤال هو إذا كان لديه الكثير من المال + +137 +00:10:55,080 --> 00:11:02,520 +جيد للعمل أم لا؟ لا لماذا؟ فإنه لا يوجد فرصة + +138 +00:11:02,520 --> 00:11:07,740 +للinvestments دعونا نذهب إلى الانتجارات هذه + +139 +00:11:07,740 --> 00:11:17,620 +الانتجارات تجمع مواقع ديل، أبل وHPوالثلاث شركات + +140 +00:11:17,620 --> 00:11:22,920 +تعمل في الكمبيوتر أو دعنا نقول البرنامج الهاردوير + +141 +00:11:22,920 --> 00:11:26,420 +لذلك + +142 +00:11:26,420 --> 00:11:31,500 +يو بوس طلب منك أن تنظر إلى ميزة ديلز لذلك يجب أن + +143 +00:11:31,500 --> 00:11:35,680 +ننظر إلى ميزة ديلز ونقوم بالتحقق من قدرتها على + +144 +00:11:35,680 --> 00:11:40,800 +وقتها باستخدام المعلومات التالية وسنقوم بتقارير + +145 +00:11:40,800 --> 00:11:47,780 +ديلز مع الشركات الأخرى، أبل وHPلذلك لديك هذه + +146 +00:11:47,780 --> 00:11:50,200 +الواقعات الواقعات الحالية الواقعات المستحيلة من + +147 +00:11:50,200 --> 00:11:52,960 +المال الانفجارات الأسعار مستخدمات الأسعار + +148 +00:11:52,960 --> 00:11:54,740 +ومستخدمات الأسعار ومستخدمات الأسعار ومستخدمات + +149 +00:11:54,740 --> 00:11:54,900 +الأسعار ومستخدمات الأسعار ومستخدمات الأسعار + +150 +00:11:54,900 --> 00:11:54,920 +ومستخدمات الأسعار ومستخدمات الأسعار ومستخدمات + +151 +00:11:54,920 --> 00:11:55,060 +ومستخدمات الأسعار ومستخدمات الأسعار ومستخدمات + +152 +00:11:55,060 --> 00:12:03,800 +ومستخدمات الأسعار ومستخدمات + +153 +00:12:03,800 --> 00:12:08,700 +الأسعار + +154 +00:12:08,700 --> 00:12:13,760 +وم + +155 +00:12:14,590 --> 00:12:19,570 +بإمكاننا أن نقوم بهذا أن الديل يحتوي على عدد عدد + +156 +00:12:19,570 --> 00:12:25,090 +عدد عدد عدد عدد عدد عدد + +157 +00:12:25,090 --> 00:12:25,430 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +158 +00:12:25,430 --> 00:12:25,710 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +159 +00:12:25,710 --> 00:12:25,770 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +160 +00:12:25,770 --> 00:12:26,150 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +161 +00:12:26,150 --> 00:12:38,990 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +162 +00:12:38,990 --> 00:12:49,780 +علذلك لديك 1.56 وهو 1.65 ومازال التقرير أكبر من + +163 +00:12:49,780 --> 00:12:58,180 +التقرير، لذلك لديك مقارنة سيئة مع .. ولكن إذا + +164 +00:12:58,180 --> 00:13:05,630 +قررتي على هذا بشأن نفسك، ستجد أنه بخيرأنا أقصد + +165 +00:13:05,630 --> 00:13:10,650 +بدون أن ننظر إلى الـ HP أو أبل لأنها أكبر من واحد + +166 +00:13:10,650 --> 00:13:17,110 +واحد بخير إذا كانت الـ Asset Test واحدة فهي جيدة + +167 +00:13:17,110 --> 00:13:20,130 +للعمل الآن انظر إلى الـ Account Receivable الـ + +168 +00:13:20,130 --> 00:13:26,590 +Account Receivable هو 7.15 مرات في السنة وهو 6 + +169 +00:13:26,590 --> 00:13:35,530 +مرات في السنةهو أفضل من عمليات الهاتف المستخدم + +170 +00:13:35,530 --> 00:13:37,430 +المستخدم المستخدم المستخدم المستخدم المستخدم + +171 +00:13:37,430 --> 00:13:38,230 +المستخدم المستخدم المستخدم المستخدم المستخدم + +172 +00:13:38,230 --> 00:13:38,430 +المستخدم المستخدم المستخدم المستخدم المستخدم + +173 +00:13:38,430 --> 00:13:39,530 +المستخدم المستخدم المستخدم المستخدم المستخدم + +174 +00:13:39,530 --> 00:13:40,550 +المستخدم المستخدم المستخدم المستخدم المستخدم + +175 +00:13:40,550 --> 00:13:40,830 +المستخدم المستخدم المستخدم المستخدم المستخدم + +176 +00:13:40,830 --> 00:13:40,870 +المستخدم المستخدم المستخدم المستخدم المستخدم + +177 +00:13:40,870 --> 00:13:41,250 +المستخدم المستخدم المستخدم المستخدم المستخدم + +178 +00:13:41,250 --> 00:13:42,590 +المستخدم المستخدم المستخدم المستخدم المستخدم + +179 +00:13:42,590 --> 00:13:48,070 +المستخدم المستخدم المستخدم المستخدم المستخدم + +180 +00:13:48,070 --> 00:13:52,850 +المستخدم الم + +181 +00:13:56,320 --> 00:14:05,940 +التحديث والتحديث العزيزي والتحديث العزيزي والتحديث + +182 +00:14:05,940 --> 00:14:07,480 +العزيزي والتحديث العزيزي والتحديث العزيزي والتحديث + +183 +00:14:07,480 --> 00:14:07,500 +العزيزي والتحديث العزيزي والتحديث العزيزي والتحديث + +184 +00:14:07,500 --> 00:14:07,620 +العزيزي والتحديث العزيزي والتحديث العزيزي والتحديث + +185 +00:14:07,620 --> 00:14:07,840 +العزيزي والتحديث العزيزي والتحديث العزيزي والتحديث + +186 +00:14:07,840 --> 00:14:09,220 +العزيزي والتحديث العزيزي والتحديث العزيزي والتحديث + +187 +00:14:09,220 --> 00:14:16,760 +العزيزي والتحديث العزيزي والتحديث العزيزي والتحديث + +188 +00:14:16,760 --> 00:14:23,180 +العزيزي والتحديث العزيز + +189 +00:14:28,940 --> 00:14:34,600 +تعود إلى الـ checkpoints و تحاول تفكير أين المشكلة + +190 +00:14:34,600 --> 00:14:40,520 +ربما المشكلة في أسعار السوق أو ربما المشكلة في + +191 +00:14:40,520 --> 00:14:47,180 +المال نفسه، فتحاول تفكير و تحكم في المشكلة. الآن + +192 +00:14:47,180 --> 00:14:49,620 +سوف نتحرك إلى الـ capital structure ratios + +193 +00:14:57,800 --> 00:15:03,620 +القيمة الواقعية تقوم + +194 +00:15:03,620 --> 00:15:09,680 +بتقاط مدى ما يعتمد عملية الشركة على المالأو كم + +195 +00:15:09,680 --> 00:15:15,820 +قيمة تستخدمها وكم قيمة تستخدمها ، لذلك كما قلت + +196 +00:15:15,820 --> 00:15:22,140 +قرار اقتصادي مرتبط بالانتصارات الانتصارات + +197 +00:15:22,140 --> 00:15:27,340 +الانتصارات الانتصارات الانتصارات + +198 +00:15:27,340 --> 00:15:29,200 +الانتصارات الانتصارات الانتصارات الانتصارات + +199 +00:15:29,200 --> 00:15:29,320 +الانتصارات الانتصارات الانتصارات الانتصارات + +200 +00:15:29,320 --> 00:15:30,700 +الانتصارات الانتصارات الانتصارات الانتصارات + +201 +00:15:30,700 --> 00:15:30,740 +الانتصارات الانتصارات الانتصارات الانتصارات + +202 +00:15:30,740 --> 00:15:30,800 +الانتصارات الانتصارات الانتصارات الانتصارات + +203 +00:15:30,800 --> 00:15:38,400 +الانتصاراتهذا بالنسبة للسياسة المالية، فهو فقط + +204 +00:15:38,400 --> 00:15:42,280 +لأذكركم بمقال T، هنا هي المواصفات الحالية وهنا + +205 +00:15:42,280 --> 00:15:46,620 +المواصفات المقلية التي تنتهي مع المواصفات الكاملة، + +206 +00:15:46,620 --> 00:15:50,760 +والآن هنا هي المواصفات المقلية أو المواصفات + +207 +00:15:50,760 --> 00:15:54,880 +الحالية وهنا لدينا المواصفات المدتنية، هذا الجزء + +208 +00:15:54,880 --> 00:15:56,720 +معروف كمواصفات كامة + +209 +00:16:00,200 --> 00:16:06,900 +والعقود المجتمعية تعتبر عقود وهي الميزة الآن + +210 +00:16:06,900 --> 00:16:13,920 +السؤال هو إذا كانت الشركة تستخدم عقود أو ميزة او + +211 +00:16:13,920 --> 00:16:14,940 +ميزة او ميزة او ميزة او ميزة او ميزة او ميزة او + +212 +00:16:14,940 --> 00:16:15,680 +ميزة او ميزة او ميزة او ميزة او ميزة او ميزة او + +213 +00:16:15,680 --> 00:16:18,720 +ميزة او ميزة او ميزة او ميزة او ميزة او ميزة او + +214 +00:16:18,720 --> 00:16:20,140 +ميزة او ميزة او ميزة او ميزة او ميزة او ميزة او + +215 +00:16:20,140 --> 00:16:26,180 +ميزة او ميزة او ميزة او ميزة او + +216 +00:16:26,180 --> 00:16:34,120 +ميزة اووالاقتصاد ما هي أفضل أسلحة لعمل الشباب أفضل + +217 +00:16:34,120 --> 00:16:38,800 +أسلحة لعمل الشباب التي تتجارب أكتر الميزة أو أكتر + +218 +00:16:38,800 --> 00:16:42,340 +ميزة أو أكتر ميزة أو أكتر ميزة أو أكتر ميزة أو + +219 +00:16:42,340 --> 00:16:42,380 +أكتر ميزة أو أكتر ميزة أو أكتر ميزة أو أكتر ميزة + +220 +00:16:42,380 --> 00:16:43,260 +أو أكتر ميزة أو أكتر ميزة أو أكتر ميزة أو أكتر + +221 +00:16:43,260 --> 00:16:44,020 +ميزة أو أكتر ميزة أو أكتر ميزة أو أكتر ميزة أو + +222 +00:16:44,020 --> 00:16:49,500 +أكتر ميزة أو أكتر ميزة أو أكتر ميزة أو أكتر ميزة + +223 +00:16:49,500 --> 00:16:56,870 +أومعرفة قيمة الشركة لا نستطيع نقول 50% هو أفضل + +224 +00:16:56,870 --> 00:17:01,010 +للشركة لا نستطيع نقول 60% أو 70%، فهو يعتمد على + +225 +00:17:01,010 --> 00:17:05,910 +مدى قيمة الشركة هذه هي القيمة الأفضل للشركة تقوم + +226 +00:17:05,910 --> 00:17:15,990 +بمعرفة قيمة الشركة، هذه هي القرارة فقط القيمة + +227 +00:17:15,990 --> 00:17:20,760 +الشركة تتعرف على طريقة إيجار أساتها الشركةكيف + +228 +00:17:20,760 --> 00:17:24,580 +يمكننا تقيم هذا؟ هناك العديد من الحيوانات التي + +229 +00:17:24,580 --> 00:17:27,680 +يمكننا تقيمها والحيوانات المهمة هي الحيوانات الـ + +230 +00:17:27,680 --> 00:17:36,480 +Debt وحيوانات الوقت المهتم بالها فالأولة التي هي + +231 +00:17:36,480 --> 00:17:40,500 +الحيوانات الـ Debt هي ترميها كعامل المساعدة + +232 +00:17:40,500 --> 00:17:43,200 +المجتمعية المجتمعية المجتمعية المجتمعية المجتمعية + +233 +00:17:43,200 --> 00:17:46,380 +المجتمعية المجتمعية المجتمعية المجتمعية المجتمعية + +234 +00:17:46,380 --> 00:17:47,620 +المجتمعية المجتمعية المجتمعية المجتمعية المجتمعية + +235 +00:17:47,620 --> 00:17:48,060 +المجتمعية المجتمعية المجتمعية المجتمعية المجتمعية + +236 +00:17:48,060 --> 00:17:48,220 +المجتمعية المجتمعية المجتمعية المجتمعية المجتمعية + +237 +00:17:48,220 --> 00:17:56,160 +المجتمعية الممن أين ندفع الواقعات الكامة؟ أو كم + +238 +00:17:56,160 --> 00:18:03,140 +نستخدم المال لدفع الواقعات الكامة؟ لذلك نستطيع + +239 +00:18:03,140 --> 00:18:06,760 +تطبيق هذا الوضع بـ Total Liabilities ÷ Total + +240 +00:18:06,760 --> 00:18:20,350 +Assetsوعندما نفعل هذا نحصل على 1012.50 ÷ 1764 نحصل + +241 +00:18:20,350 --> 00:18:29,810 +على نتيجة 57.40% مايعنيه هذا الوضع فالنتيجة هي + +242 +00:18:29,810 --> 00:18:34,590 +حوالي 57% مايعنيه هذا الوضع + +243 +00:18:38,090 --> 00:18:44,570 +ماذا يعني ال 57%؟ يعني أن 57% من مالاتنا هي + +244 +00:18:44,570 --> 00:18:52,850 +المالات المالية نعم من المالات ماهي المالات؟ ماهي + +245 +00:18:52,850 --> 00:18:56,130 +المساعدات الكامة ماهي المساعدات الكامة قصة قصة قصة + +246 +00:18:56,130 --> 00:18:58,910 +قصة قصة قصة قصة قصة قصة قصة قصة قصة قصة قصة قصة + +247 +00:18:58,910 --> 00:18:59,570 +قصة قصة قصة قصة قصة قصة قصة قصة قصة قصة قصة قصة + +248 +00:18:59,570 --> 00:19:00,990 +قصة قصة قصة قصة قصة قصة قصة قصة قصة قصة قصة قصة + +249 +00:19:00,990 --> 00:19:02,610 +قصة قصة قصة ق + +250 +00:19:05,420 --> 00:19:10,660 +على سبيل المثال أعطيك الأساتيات الأساتيات الكاملة + +251 +00:19:10,660 --> 00:19:17,520 +و أعطيك الميزانية ثم انا أغلق ما هي الميزانيات إذا + +252 +00:19:17,520 --> 00:19:21,860 +أعطيك الميزانيات الأقصر فباستخدام + +253 +00:19:21,860 --> 00:19:25,680 +هذه الميزانية تستطيع أن تعطي الميزانيات الأطول + +254 +00:19:25,680 --> 00:19:31,280 +الميزانيات الكاملة ثم الميزانية الكاملة هي + +255 +00:19:31,280 --> 00:19:34,220 +الميزانية أقل الميزانية أقل الميزانية + +256 +00:19:36,680 --> 00:19:41,700 +العقل الكام لو كنت تعرف العقل الكام وكنت تعرف + +257 +00:19:41,700 --> 00:19:46,520 +العقل الأقل يمكنك أن تعرف العقل الأطول، لهذا السبب + +258 +00:19:46,520 --> 00:19:50,980 +أنا أحاول أن أتعرف على إجابتك، فهذه هي المقالات، + +259 +00:19:50,980 --> 00:19:59,040 +ثم تذهب حتى تخلص العقل الأقل والعقل الأطول من + +260 +00:19:59,040 --> 00:19:59,660 +المقالة + +261 +00:20:02,470 --> 00:20:08,710 +حسنًا، فالسؤال الآن هو إذا كان أكثر من نصف من + +262 +00:20:08,710 --> 00:20:13,670 +الأموال الكامة مدفونة من المال، هل تعتقد أن هذا + +263 +00:20:13,670 --> 00:20:21,130 +خطر للعمل؟ نعم، لأن أكثر من 50% من الأموال مدفونة، + +264 +00:20:21,130 --> 00:20:26,090 +هذا يعني أن الآخر نصف منها مدفونة من المال + +265 +00:20:29,770 --> 00:20:33,410 +تقريبا تقريبا تقريبا تقريبا تقريبا تقريبا تقريبا + +266 +00:20:33,410 --> 00:20:36,270 +تقريبا تقريبا تقريبا تقريبا تقريبا تقريبا تقريبا + +267 +00:20:36,270 --> 00:20:36,810 +تقريبا تقريبا تقريبا تقريبا تقريبا تقريبا تقريبا + +268 +00:20:36,810 --> 00:20:37,850 +تقريبا تقريبا تقريبا تقريبا تقريبا تقريبا تقريبا + +269 +00:20:37,850 --> 00:20:37,890 +تقريبا تقريبا تقريبا تقريبا تقريبا تقريبا تقريبا + +270 +00:20:37,890 --> 00:20:38,070 +تقريبا تقريبا تقريبا تقريبا تقريبا تقريبا تقريبا + +271 +00:20:38,070 --> 00:20:38,090 +تقريبا تقريبا تقريب + +272 +00:20:44,700 --> 00:20:48,560 +أي أسئلة في هذه المقارنة؟ هناك الكثير من المقارنات + +273 +00:20:48,560 --> 00:20:52,520 +الأخرى مرتبطة بها ولكننا نركز هنا على المقارنات + +274 +00:20:52,520 --> 00:20:58,680 +المهمة. المقارنة الثانوية هي الوقت المهتم. هذه + +275 +00:20:58,680 --> 00:21:05,640 +مقارنة كم مرة تغطي شركة شركة شركة شركة شركة شركة + +276 +00:21:05,640 --> 00:21:08,000 +شركة شركة شركة شركة شركة شركة شركة شركة شركة شركة + +277 +00:21:08,000 --> 00:21:11,480 +شركة شركة شركة شركة شركة شركة شركة + +278 +00:21:11,480 --> 00:21:12,700 +شركة شركة شركة شركة شركة شركة شركة شركة شركة شركة + +279 +00:21:12,700 --> 00:21:18,130 +شركة شركة شركة شركبقيمة الهجوم والتأكيد + +280 +00:21:18,130 --> 00:21:27,230 +هو عدد المرات وكما ترى هنا 5.38 مرات ما يعني هذا + +281 +00:21:27,230 --> 00:21:34,850 +يعني ان عملي الهجوم أو عملي الهجوم عملي الهجوم + +282 +00:21:34,850 --> 00:21:35,130 +يغطي + +283 +00:21:42,380 --> 00:21:46,880 +الدفع هو 5 + +284 +00:21:46,880 --> 00:21:51,420 +.8 مرات، في + +285 +00:21:51,420 --> 00:21:56,000 +كلمات أخرى، يمكننا أن نضعها بطريقات مختلفة، فقط + +286 +00:21:56,000 --> 00:22:01,200 +نقل 1 إلى 5.38 + +287 +00:22:03,370 --> 00:22:14,030 +فاعلها واحد مقابل 5.38 هو حوالي 13% 14% 18% نعم + +288 +00:22:14,030 --> 00:22:24,310 +فقط قبل واحد واحد مقابل 5.38 18 + +289 +00:22:24,310 --> 00:22:32,490 +% ماذا يعني هذا يعني + +290 +00:22:34,330 --> 00:22:44,710 +الدفع الهجومي يمثل 18% من الدفع الهجومي يمثل + +291 +00:22:44,710 --> 00:22:48,870 +18% من الدفع الهجومي على سبيل المثال إذا كان لديك + +292 +00:22:48,870 --> 00:23:03,450 +100$ كدفع الهجومي منهم 18$ كدفع الهجومي 18% يعني + +293 +00:23:04,730 --> 00:23:11,890 +الدفعات أو دفعات الدفع يمثل 18% من الدفع العام في + +294 +00:23:11,890 --> 00:23:22,090 +كلمة أخرى إذا كان لديك دفع عام 100$ منهم 18$ يجب + +295 +00:23:22,090 --> 00:23:27,430 +أن تدفعهم كدفع دفع دفع دفع دفع دفع دفع دفع دفع دفع + +296 +00:23:27,430 --> 00:23:27,650 +دفع دفع دفع دفع دفع دفع دفع دفع دفع دفع دفع دفع + +297 +00:23:27,650 --> 00:23:30,170 +دفع دفع دفع دفع دفع دفع دفع دفع دفع + +298 +00:23:31,560 --> 00:23:38,100 +5.38 مرات تزداد، على سبيل المثال، إذا كانت مجموعة + +299 +00:23:38,100 --> 00:23:46,640 +الأعضاء 9 مرات، ماذا تعتقد؟ هل هذا أفضل للعمل أو + +300 +00:23:46,640 --> 00:23:53,020 +ماذا تعتقد؟ لديه 9 مرات أو 5 مرات، وهو جيد للعمل؟ + +301 +00:23:54,560 --> 00:23:59,220 +five times okay let's agree with you that five + +302 +00:23:59,220 --> 00:24:02,460 +times is much better than this do it in different + +303 +00:24:02,460 --> 00:24:07,040 +way let's think in different way okay so we + +304 +00:24:07,040 --> 00:24:11,560 +divided one five point three eights حكينا عن ال + +305 +00:24:11,560 --> 00:24:16,730 +five point three eights timesمع ذلك الوقت .. الوقت + +306 +00:24:16,730 --> 00:24:20,590 +الذي يتم تغييره الهدف يعني كم مرة تغيّر الهدف + +307 +00:24:20,590 --> 00:24:27,470 +التجاربية تغطي أسعار الهدف، حسنا؟ لذلك .. نحن نفضر + +308 +00:24:27,470 --> 00:24:34,070 +أن هذا الـT يكون عالي لعمل الشركة، حسنا؟ هذه + +309 +00:24:34,070 --> 00:24:40,770 +التحقيقات تساعدك في فهم مقاومة مقاومة المال إذا + +310 +00:24:40,770 --> 00:24:46,380 +قمت بقراءة هذا المثال هناهي تكون لديك المال الكام + +311 +00:24:46,380 --> 00:24:53,260 +لـ Home Depots وLouis لديك المال الكام للعامة + +312 +00:24:53,260 --> 00:24:54,840 +العامة العامة العامة العامة العامة العامة العامة + +313 +00:24:54,840 --> 00:24:55,560 +العامة العامة العامة العامة العامة العامة العامة + +314 +00:24:55,560 --> 00:24:56,060 +العامة العامة العامة العامة العامة العامة العامة + +315 +00:24:56,060 --> 00:24:57,300 +العامة العامة العامة العامة العامة العامة العامة + +316 +00:24:57,300 --> 00:24:58,100 +العامة العامة العامة العامة العامة العامة العامة + +317 +00:24:58,100 --> 00:25:00,980 +العامة العامة العامة العامة العامة العامة العامة + +318 +00:25:00,980 --> 00:25:05,040 +العامة العامة العامة العامة العامة العامة العامة + +319 +00:25:05,040 --> 00:25:09,240 +العامة + +320 +00:25:09,240 --> 00:25:15,110 +العامin debots and Louis is 43 percent it means + +321 +00:25:15,110 --> 00:25:20,010 +the debt ratio in in debots is higher than the + +322 +00:25:20,010 --> 00:25:27,330 +Louis the time interest هي is 24 and in Louis is + +323 +00:25:27,330 --> 00:25:32,170 +33 what it means then what it means the 24 for + +324 +00:25:32,170 --> 00:25:40,070 +debots and 33 for Louisthe times interest ends and + +325 +00:25:40,070 --> 00:25:45,550 +which is preferable + +326 +00:25:45,550 --> 00:25:54,630 +33 okay what it means 33 how much interest from + +327 +00:25:54,630 --> 00:25:58,790 +mine how much I pay for the loans the interest + +328 +00:25:58,790 --> 00:26:03,210 +from the loans again say it again the interest + +329 +00:26:03,210 --> 00:26:07,220 +that I pay for the loanshow much interest you + +330 +00:26:07,220 --> 00:26:16,740 +means how much times no look + +331 +00:26:16,740 --> 00:26:24,820 +at this 33 here 33 this is not interest times what + +332 +00:26:24,820 --> 00:26:28,820 +it means exactly what it means say it again how + +333 +00:26:28,820 --> 00:26:29,200 +many times + +334 +00:26:33,260 --> 00:26:36,700 +no how much is the operating income cover from the + +335 +00:26:36,700 --> 00:26:40,840 +interest yes so this is different things we may + +336 +00:26:40,840 --> 00:26:43,960 +give you like true or false and we will say this + +337 +00:26:43,960 --> 00:26:47,200 +is what you say is false but what she said is true + +338 +00:26:47,200 --> 00:26:52,140 +so how many times that the operating income covers + +339 +00:26:52,140 --> 00:26:58,650 +the interest expense okay so be careful inهو كيف + +340 +00:26:58,650 --> 00:27:06,430 +تقوم بتحسين المقارنة وهذه + +341 +00:27:06,430 --> 00:27:13,050 +هي الحلقة لـ Capital Structure على سبيل المثال + +342 +00:27:13,050 --> 00:27:18,090 +الآن سنتحدث عن مقارنة الوثيقة الهجومية الهجومية + +343 +00:27:18,090 --> 00:27:25,170 +الهجومية الهجومية الهجومية الهجومية + +344 +00:27:25,170 --> 00:27:25,670 +الهجومية + +345 +00:27:29,650 --> 00:27:33,210 +مقارنة إفعالية عملية أسطس تقوم بمقارنة إفعالية + +346 +00:27:33,210 --> 00:27:37,150 +عملية أسطس في إستخدام أسطسها لإنتاج سائل.السؤال + +347 +00:27:37,150 --> 00:27:43,490 +الكبير لهذا هو إلى ما يستخدم أسطس الأسطس التي + +348 +00:27:43,490 --> 00:27:47,790 +يحتوي على أسطس كام و أسطس مستقل لإنتاج أو إنتاج + +349 +00:27:47,790 --> 00:27:54,330 +سائل، لذلك أكتر أسطس ينتج سائل، أكتر أسطس ينتج + +350 +00:27:54,330 --> 00:28:01,020 +سائل، أكتر أسطس ينتج سائل، أكتر أسطس ينتجبإمكاننا + +351 +00:28:01,020 --> 00:28:05,060 +تغطي هذا باستخدام مقارنة الـ turnover للأموال من + +352 +00:28:05,060 --> 00:28:07,920 +الأموال الكامة للأموال الكامة للأموال المقاومة + +353 +00:28:07,920 --> 00:28:10,120 +المقاومة المقاومة المقاومة المقاومة المقاومة + +354 +00:28:10,120 --> 00:28:10,840 +المقاومة المقاومة المقاومة المقاومة المقاومة + +355 +00:28:10,840 --> 00:28:11,120 +المقاومة المقاومة المقاومة المقاومة المقاومة + +356 +00:28:11,120 --> 00:28:11,260 +المقاومة المقاومة المقاومة المقاومة المقاومة + +357 +00:28:11,260 --> 00:28:11,760 +المقاومة المقاومة المقاومة المقاومة المقاومة + +358 +00:28:11,760 --> 00:28:12,060 +المقاومة المقاومة المقاومة المقاومة المقاومة + +359 +00:28:12,060 --> 00:28:16,840 +المقاومة المقاومة المقاومة المقا + +360 +00:28:17,490 --> 00:28:26,530 +مقارنة بـ 191 لديك 1.37 مايعنيه .. مايعنيه أن 1 + +361 +00:28:26,530 --> 00:28:33,070 +دولار مستثمر في الاستخدام المجموعة يجري 1.37 سلسلة + +362 +00:28:33,070 --> 00:28:38,750 +أو 1 دولار في السلسلة إذا كنت تقارن هذا مع ال .. + +363 +00:28:38,750 --> 00:28:45,830 +مع المجموعة المشرفة ترى أن شركتنا أفضل من المجموعة + +364 +00:28:45,830 --> 00:28:50,570 +المشرفةOkay, just to pair your mind in terms of + +365 +00:28:50,570 --> 00:28:53,630 +your assignments, how we calculate the peer group, + +366 +00:28:54,110 --> 00:28:56,930 +the peer group is the average of the industry, so + +367 +00:28:56,930 --> 00:28:59,350 +be careful when you are writing your assignment on + +368 +00:28:59,350 --> 00:29:03,170 +this, and inshallah after the mid exam, I will + +369 +00:29:03,170 --> 00:29:07,110 +arrange a meeting for you to train you how to + +370 +00:29:07,110 --> 00:29:09,650 +write your assignments or how to write academic + +371 +00:29:09,650 --> 00:29:11,230 +assignments, okay? + +372 +00:29:14,440 --> 00:29:22,880 +للعام 2009 تقريبًا تقريبًا تقريبًا تقريبًا + +373 +00:29:22,880 --> 00:29:28,880 +تقريبًا تقريبًا + +374 +00:29:28,880 --> 00:29:32,700 +تقريبًا تقريبًا تقريبًا تقريبًا تقريبًا تقريبًا + +375 +00:29:32,700 --> 00:29:33,000 +تقريبًا تقريبًا تقريبًا تقريبًا تقريبًا تقريبًا + +376 +00:29:33,000 --> 00:29:33,020 +تقريبًا تقريبًا تقريبًا تقريبًا تقريبًا تقريبًا + +377 +00:29:33,020 --> 00:29:38,120 +تقريبًا تقريبًا تقريبًا تقريبًا + +378 +00:29:38,120 --> 00:29:44,140 +تقريبًا تقريبًا + +379 +00:29:44,140 --> 00:29:48,850 +تقريمن أين نستطيع الحصول على الواقعيات الواقعية + +380 +00:29:48,850 --> 00:29:54,390 +تأتي من الواقعيات + +381 +00:29:54,390 --> 00:29:55,890 +المستقلة المستقلة المستقلة المستقلة المستقلة + +382 +00:29:55,890 --> 00:29:55,910 +المستقلة المستقلة المستقلة المستقلة المستقلة + +383 +00:29:55,910 --> 00:29:56,350 +المستقلة المستقلة المستقلة المستقلة المستقلة + +384 +00:29:56,350 --> 00:30:00,050 +المستقلة المستقلة المستقلة المستقلة المستقلة + +385 +00:30:00,050 --> 00:30:05,750 +المستقلة المستقلة المستقلة المستقلة المستقلة + +386 +00:30:05,750 --> 00:30:06,810 +المستقلة المستقلة المستقلة المستقلة المستقلة + +387 +00:30:06,810 --> 00:30:09,890 +المستقلة المستقلة المستقلة المستقلة المستقلة + +388 +00:30:09,890 --> 00:30:10,130 +المستقلة المستقلة المستقلة المستقلة المستقلة + +389 +00:30:10,130 --> 00:30:16,570 +المستقلة المستقلة المستقفنحصل في عام 2009 1.94$ 1 + +390 +00:30:16,570 --> 00:30:21,610 +.94$ يعني أن 1 دولار مستقبله في مصالح مستقبل + +391 +00:30:21,610 --> 00:30:24,490 +مستقبل مستقبل مستقبل 1.94$ + +392 +00:30:36,170 --> 00:30:42,050 +حسنًا، إذا قم بتجميلهم جميعًا، ستحصل على نسبة 1.37 + +393 +00:30:42,050 --> 00:30:43,130 +اكتر من اكتر من اكتر من اكتر من اكتر من اكتر من + +394 +00:30:43,130 --> 00:30:44,410 +اكتر من اكتر من اكتر من اكتر من اكتر من اكتر من + +395 +00:30:44,410 --> 00:30:45,310 +اكتر من اكتر من اكتر من اكتر من اكتر من اكتر من + +396 +00:30:45,310 --> 00:30:48,030 +اكتر من اكتر من اكتر من اكتر من اكتر من اكتر من + +397 +00:30:48,030 --> 00:30:53,370 +اكتر من اكتر من اكتر من اكتر من اكتر من اكتر من + +398 +00:30:53,370 --> 00:30:59,630 +اكتر من اكتر + +399 +00:30:59,630 --> 00:31:02,910 +من اك + +400 +00:31:03,810 --> 00:31:07,930 +Receivable turnover وInventory turnover Receivable + +401 +00:31:07,930 --> 00:31:12,970 +turnover مدرسة إلى مدرسة ما أو كم طول من الشركة + +402 +00:31:12,970 --> 00:31:18,510 +لتحويل الـAccount receivable إلى الـCash أو ماهي + +403 +00:31:18,510 --> 00:31:24,310 +فترة التجارب لـAccount receivable كيف نستطيع تخطيط + +404 +00:31:24,310 --> 00:31:28,430 +هذا؟ Receivable turnover هو مجموعات المدفوع + +405 +00:31:28,430 --> 00:31:33,820 +المقاومة بمجموعة الـAccount receivableوهو 16.67 + +406 +00:31:33,820 --> 00:31:40,040 +مرات وهذا في الوقت وإذا أردنا تحويل هذا إلى أيام + +407 +00:31:40,040 --> 00:31:48,940 +يمكنك تحويله إلى 365 مرات و16.67 مرات وستحصل على + +408 +00:31:48,940 --> 00:31:49,840 +عدد الأيام + +409 +00:31:53,120 --> 00:31:57,880 +So the more times you are circulating .. the more + +410 +00:31:57,880 --> 00:32:00,880 +times you are circulating the account receivable, + +411 +00:32:01,420 --> 00:32:04,860 +the less number of days you need to convert + +412 +00:32:04,860 --> 00:32:09,460 +account receivable into cash So say it again, the + +413 +00:32:09,460 --> 00:32:14,160 +more time that we have to convert account + +414 +00:32:14,160 --> 00:32:18,620 +receivable into cash, the less number of days that + +415 +00:32:18,620 --> 00:32:24,470 +we need to convert account receivable into cashعلى + +416 +00:32:24,470 --> 00:32:31,830 +سبيل المثال إذا كانت شركة A الـ account turnover + +417 +00:32:31,830 --> 00:32:42,130 +لشركة A هي 17 مرات ولكن لشركة B هي 15 مرات لذلك + +418 +00:32:42,130 --> 00:32:49,810 +نحن نفضر A لأن A لديها مجتمع أفضل من شركة B هذا + +419 +00:32:49,810 --> 00:32:56,980 +يعنيالشركة لديها أقل أيام لتحويل أساته لتحويل الـ + +420 +00:32:56,980 --> 00:32:59,540 +account receivable إلى الـ cash كيف يمكننا التخيل + +421 +00:32:59,540 --> 00:33:07,080 +هذا فقط 365 مقاطع 17 و 365 مقاطع 15 مقاطع 365 + +422 +00:33:07,080 --> 00:33:08,700 +مقاطع 16 مقاطع 16 مقاطع 15 مقاطع 16 مقاطع 16 مقاطع + +423 +00:33:08,700 --> 00:33:08,980 +16 مقاطع 16 مقاطع 16 مقاطع 16 مقاطع 16 مقاطع 16 + +424 +00:33:08,980 --> 00:33:12,230 +16 مقاطع 16 مقاطع 16 مقاطع 16 مقاطع 1621 أيام و 24 + +425 +00:33:12,230 --> 00:33:16,410 +أيام لذلك نحتاج 21 أيام هنا لتحويل الاسم المستقبلي + +426 +00:33:16,410 --> 00:33:21,350 +إلى cash ولكن هنا نحتاج 24 أيام لتحويل الاسم + +427 +00:33:21,350 --> 00:33:27,530 +المستقبلي إلى cash الآن للإيقاع التحويل المستقبلي + +428 +00:33:27,530 --> 00:33:28,810 +نفس الأشياء + +429 +00:33:32,580 --> 00:33:35,860 +يمكن أن يتم تخطيطه بقيمة الأسعار التي تم تحويلها + +430 +00:33:35,860 --> 00:33:37,080 +إلى الأسعار التي تم تحويلها إلى الأسعار التي تم + +431 +00:33:37,080 --> 00:33:37,540 +تحويلها إلى الأسعار التي تم تحويلها إلى الأسعار + +432 +00:33:37,540 --> 00:33:39,080 +التي تم تحويلها إلى الأسعار التي تم تحويلها إلى + +433 +00:33:39,080 --> 00:33:41,840 +الأسعار التي تم تحويلها إلى الأسعار التي تم + +434 +00:33:41,840 --> 00:33:43,680 +تحويلها إلى الأسعار التي تم تحويلها إلى الأسعار + +435 +00:33:43,680 --> 00:33:46,240 +التي تم تحويلها إلى الأسعار التي تم تحويلها إلى + +436 +00:33:46,240 --> 00:33:48,400 +الأسعار التي تم تحويلها إلى الأسعار التي تم + +437 +00:33:48,400 --> 00:33:49,300 +تحويلها إلى الأسعار التي تم تحويلها إلى الأسعار + +438 +00:33:49,300 --> 00:33:52,080 +التي تم تحويلها إلى الأسعار التي تم تحويلها إلى + +439 +00:33:52,080 --> 00:33:57,040 +الأسعار التي تم تحويلها إلى الأسعار التيبالنسبة + +440 +00:33:57,040 --> 00:34:05,340 +للساعات فقط قمنا بتقسيمها من 365 إلى 3.36 ونحتاج + +441 +00:34:05,340 --> 00:34:13,240 +حوالي 92 أو 93 أيام ل .. 109 + +442 +00:34:13,240 --> 00:34:20,820 +أيام لتحويل المصادر إلى المال أو لـ 10 عبر المصادر + +443 +00:34:20,820 --> 00:34:24,360 +لـ 10 عبر المصادر + +444 +00:34:28,620 --> 00:34:33,520 +عندما نضيف جميع النتائج مع بعض نحو الـ 10 عشوائية + +445 +00:34:33,520 --> 00:34:36,660 +عشوائية عشوائية عشوائية عشوائية عشوائية عشوائية + +446 +00:34:36,660 --> 00:34:37,960 +عشوائية عشوائية عشوائية عشوائية عشوائية عشوائية + +447 +00:34:37,960 --> 00:34:38,500 +عشوائية عشوائية عشوائية عشوائية عشوائية عشوائية + +448 +00:34:38,500 --> 00:34:39,100 +عشوائية عشوائية عشوائية عشوائية عشوائية عشوائية + +449 +00:34:39,100 --> 00:34:51,240 +عشوائية عشوائية عشوائية عش + +450 +00:34:54,020 --> 00:34:59,280 +we just put click on .. on the .. on the one that + +451 +00:34:59,280 --> 00:35:02,680 +we prefer for this is preferable, the password is + +452 +00:35:02,680 --> 00:35:05,040 +preferable and in terms of fixed asset is + +453 +00:35:05,040 --> 00:35:09,080 +preferable .. preferable too and in receivable as + +454 +00:35:09,080 --> 00:35:13,420 +well, so .. but we have problems in inventory + +455 +00:35:13,420 --> 00:35:20,280 +turnoverالمجموعات مخصصة ومفيدة أكتر من المجموعات + +456 +00:35:20,280 --> 00:35:24,220 +المخصصة أيضًا مفيدة أكتر من المجموعات المخصصة + +457 +00:35:24,220 --> 00:35:30,920 +ومخصصة التجارب مخصصة أيضًا ولكن المشكلة في تغيير + +458 +00:35:30,920 --> 00:35:36,240 +المخصصة لذلك يجب أن نعرف لماذا هذا المشكلة ربما + +459 +00:35:36,240 --> 00:35:41,670 +لدينا مخصصة تغييرو ربما ندفع المال أكتر إلى + +460 +00:35:41,670 --> 00:35:47,170 +المصادر و نبقى بعض المادات غير محتاجة مادات غير + +461 +00:35:47,170 --> 00:35:52,450 +محتاجة في المصادر، يجب أن نفكر في طرق المصادر، + +462 +00:35:52,450 --> 00:35:55,850 +يمكننا أن نستخدم طرق غير مفيدة في البقاء في + +463 +00:35:55,850 --> 00:36:00,450 +المصادربعض الشركات يستخدمون just in وبعض الشركات + +464 +00:36:00,450 --> 00:36:06,470 +يستخدمون طرح أخرى لتعامل الانفجار لذلك يمكن أن + +465 +00:36:06,470 --> 00:36:14,190 +تركز على الانفجار و تحسن الوضع هنا سوف نتحدث الآن + +466 +00:36:14,190 --> 00:36:19,050 +عن مقارنة الفائزة هل هناك أسئلة قبل أن نتحرك إلى + +467 +00:36:19,050 --> 00:36:20,610 +مقارنة الفائزة؟ + +468 +00:36:28,180 --> 00:36:33,780 +Okay, any question؟ + +469 +00:36:33,780 --> 00:36:38,480 +Okay, the profitability ratios measures to the + +470 +00:36:38,480 --> 00:36:42,260 +extent that business generate profits from + +471 +00:36:42,260 --> 00:36:46,820 +different areas from the gross, from the operating + +472 +00:36:46,820 --> 00:36:54,860 +and after paying interest and taxesوهي الأشياء + +473 +00:36:54,860 --> 00:36:56,880 +الرئيسية، الأشياء الثانوية تساعدنا في تحقيق + +474 +00:36:56,880 --> 00:36:57,680 +الميزانيات في تحقيق الميزانيات تساعدنا في تحقيق + +475 +00:36:57,680 --> 00:37:00,160 +الميزانيات تساعدنا في تحقيق الميزانيات تساعدنا في + +476 +00:37:00,160 --> 00:37:03,840 +تحقيق الميزانيات تساعدنا في تحقيق الميزانيات + +477 +00:37:03,840 --> 00:37:05,960 +تساعدنا في تحقيق الميزانيات تساعدنا في تحقيق + +478 +00:37:05,960 --> 00:37:06,460 +الميزانيات تساعدنا في تحقيق الميزانيات تساعدنا في + +479 +00:37:06,460 --> 00:37:10,500 +تحقيق الميزانيات تساعدنا في تحقيق الميزانيات + +480 +00:37:10,500 --> 00:37:19,040 +تساعدنا في تحقيق الميزانيات تساعدنا + +481 +00:37:19,040 --> 00:37:22,120 +في تحقيق الميزاني + +482 +00:37:26,740 --> 00:37:32,100 +إذا اتجارات أساسية فام الانتجارات الأولى هي التحكم + +483 +00:37:32,100 --> 00:37:36,620 +بالسعر كيف ننظر إلى السعر ونعرف أن السعر يأتي من + +484 +00:37:36,620 --> 00:37:40,120 +السعر الخاص بالمواد التي يتم تحقيقها ويأتي من + +485 +00:37:40,120 --> 00:37:42,240 +السعر الخاص بالمواد التي يتم تحقيقها ويأتي من + +486 +00:37:42,240 --> 00:37:43,520 +السعر الخاص بالمواد التي يتم تحقيقها ويأتي من + +487 +00:37:43,520 --> 00:37:43,620 +السعر الخاص بالمواد التي يتم تحقيقها ويأتي من + +488 +00:37:43,620 --> 00:37:44,180 +السعر الخاص بالمواد التي يتم تحقيقها ويأتي من + +489 +00:37:44,180 --> 00:37:46,320 +السعر الخاص بالمواد التي يتم تحقيقها ويأتي من + +490 +00:37:46,320 --> 00:37:46,960 +السعر الخاص بالمواد التي يتم تحقيقها ويأتي من + +491 +00:37:46,960 --> 00:37:55,580 +السعر الخاص بالمواد التي يتم تحقيقها و + +492 +00:37:57,680 --> 00:38:01,960 +عن كيفية استخدام السوق وكيفية إدارة الأجهزة + +493 +00:38:01,960 --> 00:38:07,380 +والأجهزة والشبكات في إجراء السوق، فنحن نبحث عن + +494 +00:38:07,380 --> 00:38:11,260 +الاثنين الأهم الأشياء عندما نقوم بالتأكيد عمليات + +495 +00:38:11,260 --> 00:38:19,560 +التسريب والسعر والإيقاف من استخدام السوق.الأول هو + +496 +00:38:19,560 --> 00:38:24,560 +عمليات التسريب عمليات التسريب هي عمليات التسريب + +497 +00:38:24,560 --> 00:38:25,900 +مقاطعة بالسوق + +498 +00:38:28,400 --> 00:38:37,380 +وإذا تخطط هذا الـ Gross Profits 650 مليون و 2500 + +499 +00:38:37,380 --> 00:38:47,360 +مليون، فتحصل على 26% 26% يعني أن 1 دولار في السوق + +500 +00:38:47,360 --> 00:38:54,350 +يحصل على 26 دولارas gross profits so it means in + +501 +00:38:54,350 --> 00:38:58,010 +other words one dollar in sales this is the one + +502 +00:38:58,010 --> 00:39:06,790 +dollar in sales twenty six cents is gross profits + +503 +00:39:06,790 --> 00:39:18,550 +and seventy four is cost of goods so we think that + +504 +00:39:18,550 --> 00:39:24,140 +this is highإذا كنت تنظر إلى هذه المنطقة هنا هي + +505 +00:39:24,140 --> 00:39:30,040 +عالية لأن هناك .. نعم هناك مكان لإستخدام أسعار + +506 +00:39:30,040 --> 00:39:34,640 +أخرى ولكن لاحقًا هذا مقارنة مع .. مع أسعار الأسعار + +507 +00:39:34,640 --> 00:39:41,520 +قليلاً، لذلك بخير إذا كنا نفكر في كيف نحفظ أسعار + +508 +00:39:41,520 --> 00:39:45,580 +الأسعار ونفكر في كيف نستطيع تنظيم هذا + +509 +00:39:52,440 --> 00:39:56,780 +الثاني هو مقارنة + +510 +00:39:56,780 --> 00:39:57,940 +الناتج الناتج الناتج الناتج الناتج الناتج الناتج + +511 +00:39:57,940 --> 00:39:58,780 +الناتج الناتج الناتج الناتج الناتج الناتج الناتج + +512 +00:39:58,780 --> 00:39:59,720 +الناتج الناتج الناتج الناتج الناتج الناتج الناتج + +513 +00:39:59,720 --> 00:39:59,880 +الناتج الناتج الناتج الناتج الناتج الناتج الناتج + +514 +00:39:59,880 --> 00:40:00,040 +الناتج الناتج الناتج الناتج الناتج الناتج الناتج + +515 +00:40:00,040 --> 00:40:00,080 +الناتج الناتج الناتج الناتج الناتج الناتج الناتج + +516 +00:40:00,080 --> 00:40:14,960 +الناتج الناتج الناتج الناتج النا + +517 +00:40:16,110 --> 00:40:18,790 +والحصول على مستخدم مستخدم مستخدم مستخدم مستخدم + +518 +00:40:18,790 --> 00:40:19,430 +مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم + +519 +00:40:19,430 --> 00:40:21,210 +مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم + +520 +00:40:21,210 --> 00:40:22,270 +مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم + +521 +00:40:22,270 --> 00:40:26,230 +مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم + +522 +00:40:26,230 --> 00:40:28,030 +مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم + +523 +00:40:28,030 --> 00:40:28,350 +مستخدم مستخدم مستخدم مستخ + +524 +00:40:31,600 --> 00:40:36,920 +مرة أخرى نحن لدينا 26% من مجموعات البروفيط والنت + +525 +00:40:36,920 --> 00:40:41,200 +البروفيط + +526 +00:40:41,200 --> 00:40:49,420 +المعمل هو 14% فقط انظر لهذا وانظر لهذا لماذا + +527 +00:40:49,420 --> 00:40:52,600 +مجموعات + +528 +00:40:52,600 --> 00:40:58,420 +البروفيط المعمل أو البروفيط المعمل تتخلص من 14%؟ + +529 +00:40:58,420 --> 00:41:04,660 +نعمأي مقارنة؟ انت محق مقارنة عملية عملية عملية + +530 +00:41:04,660 --> 00:41:06,420 +عملية عملية عملية عملية عملية عملية عملية عملية + +531 +00:41:06,420 --> 00:41:10,240 +عملية عملية عملية + +532 +00:41:10,240 --> 00:41:12,200 +عملية عملية عملية عملية عملية عملية عملية عملية + +533 +00:41:12,200 --> 00:41:12,320 +عملية عملية عملية عملية عملية عملية عملية عملية + +534 +00:41:12,320 --> 00:41:12,340 +عملية عملية عملية عملية عملية عملية عملية عملية + +535 +00:41:12,340 --> 00:41:12,720 +عملية عملية عملية عملية عملية عملية عملية عملية + +536 +00:41:12,720 --> 00:41:12,740 +عملية عملية عملية عملية عملية عملية عملية عملية + +537 +00:41:12,740 --> 00:41:29,780 +عملية عملية عملية عملية عملية عملية عمل + +538 +00:41:30,730 --> 00:41:36,770 +على سبيل المثال في هذا البرنامج نحتاج 74% من + +539 +00:41:36,770 --> 00:41:41,690 +الأسعار لتغطي أسعار الأسعار والباقية هي البرنامج + +540 +00:41:41,690 --> 00:41:47,990 +العامة ولكن هنا نحتاج 12% لتغطي الأسعار الأسعار + +541 +00:41:47,990 --> 00:41:55,010 +العملية، فالاتنين الأشياء مهمة + +542 +00:41:55,010 --> 00:42:03,790 +بالمقارنة مع المجموعة العامة هي 15%وهو أكتر من + +543 +00:42:03,790 --> 00:42:11,710 +شركتنا، او شركتنا، لذلك يعني أنها أقل مفيدة من + +544 +00:42:11,710 --> 00:42:16,970 +مجموعة العضلات، حسنًا، + +545 +00:42:16,970 --> 00:42:23,170 +لـ 2009، إذا تخططنا هذا لـ 2009، مجموعة العمل، إذا + +546 +00:42:23,170 --> 00:42:24,810 +رأينا أن السعر هو 2500 + +547 +00:42:27,280 --> 00:42:31,280 +والدفع التجاري هو 350 مليون دولار تقريبا تقريبا + +548 +00:42:31,280 --> 00:42:34,380 +تقريبا تقريبا تقريبا تقريبا تقريبا تقريبا تقريبا + +549 +00:42:34,380 --> 00:42:37,220 +تقريبا تقريبا تقريبا تقريبا تقريبا تقريبا تقريبا + +550 +00:42:37,220 --> 00:42:37,340 +تقريبا تقريبا تقريبا تقريبا تقريبا تقريبا تقريبا + +551 +00:42:37,340 --> 00:42:54,620 +تقريبا تقريبا تقريبا تقريبا تق + +552 +00:42:55,760 --> 00:42:59,080 +بالتالي فان جنرلت 0.14% من النار المستخدمة لكل + +553 +00:42:59,080 --> 00:43:04,060 +دولار مستخدم في السوق فتفكر + +554 +00:43:04,060 --> 00:43:12,300 +أنك عندما تتعامل مع مقارنة النار المستخدمة نحن + +555 +00:43:12,300 --> 00:43:20,460 +لدينا فاس 26% ثم نحن لدينا 14% ثم سنرى فهذا هو + +556 +00:43:20,460 --> 00:43:20,940 +مقارنة النار المستخدمة + +557 +00:43:25,800 --> 00:43:27,580 +مقارنة وهذه مقارنة التجارب التجاربية التجاربية + +558 +00:43:27,580 --> 00:43:29,600 +التجاربية التجاربية التجاربية التجاربية التجاربية + +559 +00:43:29,600 --> 00:43:30,600 +التجاربية التجاربية التجاربية التجاربية التجاربية + +560 +00:43:30,600 --> 00:43:31,780 +التجاربية التجاربية التجاربية التجاربية التجاربية + +561 +00:43:31,780 --> 00:43:32,320 +التجاربية التجاربية التجاربية التجاربية التجاربية + +562 +00:43:32,320 --> 00:43:34,460 +التجاربية التجاربية التجاربية التجاربية التجاربية + +563 +00:43:34,460 --> 00:43:36,140 +التجاربية التجاربية التجاربية التجاربية التجاربية + +564 +00:43:36,140 --> 00:43:36,520 +التجاربية التجاربية التجاربية التجاربية التجاربية + +565 +00:43:36,520 --> 00:43:40,700 +التجاربية + +566 +00:43:40,700 --> 00:43:44,080 +التجاربية + +567 +00:43:44,080 --> 00:43:54,060 +التجاربية التجاربية + +568 +00:43:54,060 --> 00:43:59,150 +التجOkay, but if we have problems in generating + +569 +00:43:59,150 --> 00:44:03,810 +gross, it means we may face challenges in the + +570 +00:44:03,810 --> 00:44:07,290 +operating expenses and paying interest and taxes + +571 +00:44:07,290 --> 00:44:10,710 +So this is the most important one + +572 +00:44:15,200 --> 00:44:19,600 +وأيضًا مشكلة مهمة، قيمة الأسعار التي تم تحفظها هي + +573 +00:44:19,600 --> 00:44:28,160 +أعلى قيمة في المشروع لأن المشروع يعتمد على هذا، + +574 +00:44:28,160 --> 00:44:31,840 +وفي الواضح أنه يعتمد على هذا في المشروع التصنيعي + +575 +00:44:31,840 --> 00:44:35,700 +الآن، + +576 +00:44:35,700 --> 00:44:38,640 +انظر إلى مجموعة النات بروفت متساومة بمجموعة النات + +577 +00:44:38,640 --> 00:44:40,340 +بروفت متساومة + +578 +00:44:47,940 --> 00:44:58,020 +و 8.71 دولار يعني 1 دولار في السوق يجعل 8.71 دولار + +579 +00:44:58,020 --> 00:45:01,820 +أساساً أساساً 8.71 دولار في السوق يجعل 8.71 دولار + +580 +00:45:01,820 --> 00:45:06,180 +أساساً 8.71 دولار أساساً 8.71 دولار أساساً 8.71 + +581 +00:45:06,180 --> 00:45:07,160 +دولار أساساً 8.71 دولار أساساً 8.71 دولار أساساً 8 + +582 +00:45:07,160 --> 00:45:09,900 +.71 دولار أساساً 8.71 دولار أساساً 8.71 دولار + +583 +00:45:09,900 --> 00:45:13,060 +دولار أساساً 8.71 دولار أساساً 8.71 دولار أساساً 8 + +584 +00:45:13,060 --> 00:45:17,080 +.71 دولار أساساة 8.71 دولار أساساة 85% 5.30% + +585 +00:45:17,080 --> 00:45:29,820 +للأهداف والدفعات وهنا 12% يستخدمها لأسعار العمل أو + +586 +00:45:29,820 --> 00:45:39,880 +الأسعار العملية ونحن لدينا 74% لسعر الأسعارنقوم + +587 +00:45:39,880 --> 00:45:45,100 +باستخدام 2 أشياء في الوقت المناسب والسعر نقوم + +588 +00:45:45,100 --> 00:45:53,980 +باستخدام 2 أشياء في الوقت المناسب والان + +589 +00:45:53,980 --> 00:45:59,620 +نتحدث عن .. فهل يوجد أسئلة مرتبطة مع مجموعة + +590 +00:45:59,620 --> 00:46:05,720 +الانترنت؟ مجموعة الانترنت والمجموعة العاملة؟ أي + +591 +00:46:05,720 --> 00:46:11,750 +أسئلة؟ حسنادعونا نتحرك إلى المقارنة الاخرى للتفويت + +592 +00:46:11,750 --> 00:46:19,850 +وهذا يقوم بمقارنة إيجابية أساتز في تجريم السالز أو + +593 +00:46:19,850 --> 00:46:28,790 +تجريم الأرباح تجريم التفويت على أساتز تجريم + +594 +00:46:28,790 --> 00:46:34,350 +التفويت على أساتز هذا يتم تخطيطه بمجموعة تجريم + +595 +00:46:34,350 --> 00:46:37,690 +التفويت على أساتز تجريم تفويت على أساتز تجريم + +596 +00:46:37,690 --> 00:46:37,730 +تفويت على أساتز تجريم تفويت على أساتز تجريم تفويت + +597 +00:46:37,730 --> 00:46:38,030 +على أساتز تجريم تفويت على أساتز تجريم تفويت على + +598 +00:46:38,030 --> 00:46:41,710 +تجريم تفوdivided by the total assets it means the + +599 +00:46:41,710 --> 00:46:44,590 +one dollar invested in total assets how much + +600 +00:46:44,590 --> 00:46:49,330 +generate as operating income okay or in other + +601 +00:46:49,330 --> 00:46:53,010 +words how many times the operating income covers + +602 +00:46:53,010 --> 00:46:56,810 +the total assets this is in other words let's see + +603 +00:46:56,810 --> 00:46:59,170 +the this here + +604 +00:47:09,620 --> 00:47:15,540 +ماذا غير صح؟ حسنا، فمجموعة نت الروحية هي نت + +605 +00:47:15,540 --> 00:47:19,520 +الانقام مقاطعة السوق، أعتقد أننا نتحدث عن هذا + +606 +00:47:19,520 --> 00:47:28,060 +المجموعة تعمل على أساتز، كما قلنا في الأسلحة + +607 +00:47:28,060 --> 00:47:31,800 +الأولى، هي مرتبطة بالتحكم في الأسعار والإيقاع في + +608 +00:47:31,800 --> 00:47:32,020 +الأسعار، + +609 +00:47:35,870 --> 00:47:40,570 +إذا الـ Operating Return on Assets هو مجموعة من + +610 +00:47:40,570 --> 00:47:45,070 +اتنين أشياء مجموعة من بعض الأشياء من الميزة التي + +611 +00:47:45,070 --> 00:47:49,470 +تقوم بمقارنة افعالية الروحانية أو مقارنة الروحانية + +612 +00:47:49,470 --> 00:47:54,550 +والتي تأتي من الـ Balance Sheet التي تقوم بمقارنة + +613 +00:47:54,550 --> 00:47:58,670 +افعالية الروحانية لذلك عندما نتحدث عن Operating + +614 +00:47:58,670 --> 00:48:01,530 +Return on Assets لدينا مقارنة الروحانية + +615 +00:48:04,610 --> 00:48:08,870 +والسعر المستفيد والمستفيدات والمستفيدات + +616 +00:48:08,870 --> 00:48:12,590 +والمستفيدات والمستفيدات والمستفيدات والمستفيدات + +617 +00:48:12,590 --> 00:48:17,150 +والمستفيدات والمستفيدات والمستفيدات والمستفيدات + +618 +00:48:17,150 --> 00:48:19,170 +والمستفيدات والمستفيدات والمستفيدات والمستفيدات + +619 +00:48:19,170 --> 00:48:21,370 +والمستفيدات والمستفيدات والمستفيدات والمستفيدات + +620 +00:48:21,370 --> 00:48:21,390 +والمستفيدات والمستفيدات والمستفيدات والمستفيدات + +621 +00:48:21,390 --> 00:48:21,430 +والمستفيدات والمستفيدات والمستفيدات والمستفيدات + +622 +00:48:21,430 --> 00:48:22,750 +والمستفيدات والمستفيدات والمستفيدات والمستفيدات + +623 +00:48:22,750 --> 00:48:27,620 +والمستفيدات والمستفيدمع المحافظة المحافظة المحافظة + +624 +00:48:27,620 --> 00:48:27,780 +المحافظة المحافظة المحافظة المحافظة المحافظة + +625 +00:48:27,780 --> 00:48:31,340 +المحافظة المحافظة المحافظة المحافظة المحافظة + +626 +00:48:31,340 --> 00:48:36,360 +المحافظة المحافظة المحافظة المحافظة المحافظة + +627 +00:48:36,360 --> 00:48:40,260 +المحافظة المحافظة المحافظة المحافظة + +628 +00:48:40,260 --> 00:48:40,800 +المحافظة المحافظة المحافظة المحافظة المحافظة + +629 +00:48:40,800 --> 00:48:40,860 +المحافظة المحافظة المحافظة المحافظة المحافظة + +630 +00:48:40,860 --> 00:48:48,380 +المحافظة المحافظة المح + +631 +00:48:48,440 --> 00:48:55,640 +إذا كان لديك الميزة العملية من الوصفة والميزة + +632 +00:48:55,640 --> 00:48:56,260 +العملية من الميزة العملية من الميزة العملية من + +633 +00:48:56,260 --> 00:48:57,040 +من الميزة العملية من الميزة العملية من الميزة + +634 +00:48:57,040 --> 00:48:58,460 +العملية من الميزة العملية من الميزة العملية من + +635 +00:48:58,460 --> 00:48:59,020 +الميزة العملية من الميزة العملية من الميزة العملية + +636 +00:48:59,020 --> 00:49:01,220 +من الميزة العملية من الميزة العملية من الميزة + +637 +00:49:01,220 --> 00:49:01,400 +العملية من الميزة العملية من الميزة العملية من + +638 +00:49:01,400 --> 00:49:02,060 +الميزة العملية من الميزة العملية من الميزة العملية + +639 +00:49:02,060 --> 00:49:02,700 +من الميزة العملية من الميزة العملية من الميزة + +640 +00:49:02,700 --> 00:49:07,580 +العملية من + +641 +00:49:07,580 --> 00:49:09,040 +الميزة + +642 +00:49:19,730 --> 00:49:25,470 +هو لديه عدد عملية أكتر على أساتيات أو عاملات أكتر + +643 +00:49:25,470 --> 00:49:31,030 +من الـ peer group كيف نتخيل هذا؟ كيف نحصل على الـ + +644 +00:49:31,030 --> 00:49:36,520 +19%؟ فقط اذهب للـreturn on asset is equal to + +645 +00:49:36,520 --> 00:49:39,400 +operating profit margin and I showed you how is + +646 +00:49:39,400 --> 00:49:43,780 +how we estimate this total asset turnover so sales + +647 +00:49:43,780 --> 00:49:47,040 +divided by total sales we have fourteen percent + +648 +00:49:47,040 --> 00:49:50,760 +times one point thirty seven and we have the same + +649 +00:49:50,760 --> 00:49:54,040 +okay + +650 +00:49:54,040 --> 00:50:00,100 +the + +651 +00:50:00,100 --> 00:50:01,140 +importance of + +652 +00:50:06,370 --> 00:50:12,510 +مهمة إستعمال الـ Return on Assets هو كما قلنا إنها + +653 +00:50:12,510 --> 00:50:15,990 +تأثير على المعاملات السعية أو المعاملات التجاربية + +654 +00:50:15,990 --> 00:50:22,650 +ومعاملات الإيفيشنس أو إستخدام الممارسة، لذلك من + +655 +00:50:22,650 --> 00:50:29,170 +المهم أن ننظر إلى كيف نقدر نقل المساعدةو كما ذكرنا + +656 +00:50:29,170 --> 00:50:33,590 +سابقًا عن الانفجار لأننا نلاحظ أن الانفجار مرتفع + +657 +00:50:33,590 --> 00:50:39,610 +في الـ Password لذلك يجب أن نفكر و كما ذكرنا عندما + +658 +00:50:39,610 --> 00:50:45,150 +أتكلم عن 74% إنه مرتفع لذلك يجب أن نفكر على قيم + +659 +00:50:45,150 --> 00:50:49,190 +السعيد اللذي تم صنعه لذلك النتيجة هي أن الشركة يجب + +660 +00:50:49,190 --> 00:50:53,630 +أن تحقق قيم السعيد اللذي تم صنعه وخدمات العمل لنرى + +661 +00:50:53,630 --> 00:51:00,380 +إذا كان هناك فرصة لتقسيم القيمولكن عندما ألاحظ أنه + +662 +00:51:00,380 --> 00:51:08,120 +26% من الأسعار الزراعية ويعني أن المساعدة 74% بشكل + +663 +00:51:08,120 --> 00:51:13,260 +عام، لدينا مشكلة في أسعار الأسعار وهذا سيأثر على + +664 +00:51:13,260 --> 00:51:20,090 +الترتيب على الأموال وهو واضح جداونختم الأشياء + +665 +00:51:20,090 --> 00:51:26,610 +الأخرى، عادة على المصادر لأن عامة أسعار السعوديين + +666 +00:51:26,610 --> 00:51:29,810 +لديها فرصة عامة عامة عامة عامة عامة عامة عامة عامة + +667 +00:51:29,810 --> 00:51:30,030 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +668 +00:51:30,030 --> 00:51:30,230 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +669 +00:51:30,230 --> 00:51:31,030 +عامة عامة عامة + +670 +00:51:37,230 --> 00:51:41,170 +هذه محاولات التحقيق لتحقيق مستخدم التحقيق على + +671 +00:51:41,170 --> 00:51:44,550 +مستخدم الأسعار لديك مصادر مستخدم مستخدم مستخدم + +672 +00:51:44,550 --> 00:51:45,110 +مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم + +673 +00:51:45,110 --> 00:51:45,270 +مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم + +674 +00:51:45,270 --> 00:51:45,790 +مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم مستخدم + +675 +00:51:45,790 --> 00:51:49,190 +مستخدم مستخدم مستخدم مستخدم + +676 +00:51:49,190 --> 00:51:56,720 +مستخدم مستخدمالـ Return on Assets لأنك لديك الـ + +677 +00:51:56,720 --> 00:52:00,800 +Total Assets تفضل هذه التخطيطات الـ Operating + +678 +00:52:00,800 --> 00:52:03,740 +Return on Assets لديك الـ Operating Profit Margin + +679 +00:52:03,740 --> 00:52:05,200 +مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة + +680 +00:52:05,200 --> 00:52:05,580 +مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة + +681 +00:52:05,580 --> 00:52:06,500 +مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة + +682 +00:52:06,500 --> 00:52:07,380 +مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة + +683 +00:52:07,380 --> 00:52:10,140 +مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة + +684 +00:52:10,140 --> 00:52:10,380 +مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة + +685 +00:52:10,380 --> 00:52:10,700 +مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة + +686 +00:52:10,700 --> 00:52:18,240 +مرة مرة مرة مرة + +687 +00:52:26,480 --> 00:52:37,040 +تأخذ واحد دقيقة لتحقق النتائج إعادة + +688 +00:52:37,040 --> 00:52:42,000 +العمل + +689 +00:52:42,000 --> 00:52:53,280 +هي 18% 18.55% 10.65 10.98 1.74 1.60 27 + +690 +00:52:57,610 --> 00:53:11,590 +4.76 2.95 لنبدأ + +691 +00:53:11,590 --> 00:53:12,310 +بالأولة + +692 +00:53:14,930 --> 00:53:20,330 +العادة العملية على الأساتيات هي 18.51% في الـ Home + +693 +00:53:20,330 --> 00:53:25,890 +Depot 2007 بالمقارنة بلويس هي 18.55% ماذا تعتقدين + +694 +00:53:25,890 --> 00:53:33,130 +عن هذا؟ الثاني، لكن ليس هناك اختلاف مهم بينهم، نعم + +695 +00:53:33,130 --> 00:53:38,410 +أنت محق، نحن نفضع الثاني، ولكن لا اختلاف مهم بين + +696 +00:53:38,410 --> 00:53:43,880 +الأول والثاني، حسنا؟انظروا إلى الشخص الثاني يعمل + +697 +00:53:43,880 --> 00:53:52,980 +مقارنة الروحانية 10.65% و 10.98% فماذا تعتقد؟ خلود + +698 +00:53:52,980 --> 00:53:58,740 +ماذا تعتقد؟ هل + +699 +00:53:58,740 --> 00:54:06,490 +تعتقد أن هناك اختلاف كبير بينهم؟ لا لا اختلافOkay, + +700 +00:54:06,510 --> 00:54:14,110 +total asset turnover is 1.74 and 1.69 what it + +701 +00:54:14,110 --> 00:54:18,310 +means this? it means the assets generating more + +702 +00:54:18,310 --> 00:54:23,130 +sales than the second one which means they have + +703 +00:54:23,130 --> 00:54:27,190 +more efficiency in terms of managing the assets + +704 +00:54:27,190 --> 00:54:32,770 +but still the 1.74 is not that big difference + +705 +00:54:32,770 --> 00:54:37,000 +between themالان انظر إلى الـ account receivable + +706 +00:54:37,000 --> 00:54:43,560 +turnover نحن لدينا 27 و 291 اعتقد ان هناك شيء خاطئ + +707 +00:54:43,560 --> 00:54:50,320 +مع الرويس 291 يعني انه كل 2 أيام او كل يوم و نصف + +708 +00:54:50,320 --> 00:54:56,100 +يقوموا بتحويل ال account receivable الى cash يجب + +709 +00:54:56,100 --> 00:54:59,160 +أن نفكر مرتين في هذا الموضوع الـ Inventory + +710 +00:54:59,160 --> 00:55:01,680 +turnover ماذا تفكر؟ + +711 +00:55:09,220 --> 00:55:18,140 +الأولى ما زالت لا اختلاف كبير 4.76 و 4.30 اكتر + +712 +00:55:18,140 --> 00:55:19,200 +اكتر اكتر اكتر اكتر اكتر اكتر اكتر اكتر اكتر اكتر + +713 +00:55:19,200 --> 00:55:19,240 +اكتر اكتر اكتر اكتر اكتر اكتر اكتر اكتر اكتر اكتر + +714 +00:55:19,240 --> 00:55:19,720 +اكتر اكتر اكتر اكتر اكتر اكتر اكتر اكتر اكتر اكتر + +715 +00:55:19,720 --> 00:55:20,800 +اكتر اكتر اكتر اكتر اكتر اكتر اكتر اكتر اكتر اكتر + +716 +00:55:20,800 --> 00:55:27,260 +اكتر اكتر اكتر اكتر اكتر اكتر اكتر اكتر اكتر + +717 +00:55:27,260 --> 00:55:30,590 +ااستخدام الواحدة لأنها استخدام واحدة مستقل تتحول + +718 +00:55:30,590 --> 00:55:32,070 +إلى واحدة مستقل تتحول إلى واحدة مستقل تتحول إلى + +719 +00:55:32,070 --> 00:55:33,450 +واحدة مستقل تتحول إلى واحدة مستقل تتحول إلى واحدة + +720 +00:55:33,450 --> 00:55:36,050 +مستقل تتحول إلى واحدة مستقل تتحول إلى واحدة مستقل + +721 +00:55:36,050 --> 00:55:39,690 +تتحول إلى واحدة + +722 +00:55:39,690 --> 00:55:42,670 +مستقل تتحول إلى واحدة مستقل تتحول إلى واحدة مستقل + +723 +00:55:42,670 --> 00:55:45,830 +تتحول إلى واحدة مستقل تتحول إلى واحدة مستقل تتحول + +724 +00:55:45,830 --> 00:55:47,190 +إلى واحدة مستقل تتحول إلى واحدة مستقل تتحول إلى + +725 +00:55:47,190 --> 00:55:51,850 +واحدة مستقل تتحول إلى واحدة مستقل تتحول إلى واحدة + +726 +00:55:55,220 --> 00:55:56,380 +هي عملية عملية عملية عملية عملية عملية عملية عملية + +727 +00:55:56,380 --> 00:55:57,660 +عملية عملية عملية عملية عملية عملية عملية عملية + +728 +00:55:57,660 --> 00:55:58,780 +عملية عملية عملية عملية عملية عملية عملية عملية + +729 +00:55:58,780 --> 00:55:58,940 +عملية عملية عملية عملية عملية عملية عملية عملية + +730 +00:55:58,940 --> 00:56:01,320 +عملية عملية عملية عملية عملية عملية عملية عملية + +731 +00:56:01,320 --> 00:56:01,860 +عملية عملية عملية عملية عملية عملية عملية عملية + +732 +00:56:01,860 --> 00:56:06,400 +عملية عملية عملية عملية عملية عملية عملية عملية + +733 +00:56:06,400 --> 00:56:06,560 +عملية عملية عملية عملية عملية عملية عملية عملية + +734 +00:56:06,560 --> 00:56:08,580 +عملية عملية + +735 +00:56:12,600 --> 00:56:17,100 +لإستماع هذا، نستخدم ثلاث مقارنة، واحد، اثنان، + +736 +00:56:17,100 --> 00:56:22,500 +وثلاثة. الأول هو مقارنة التفويت، والثاني هو مقارنة + +737 +00:56:22,500 --> 00:56:29,180 +التفويت والثالث هو المزيد من الميزة. نتحدث عن + +738 +00:56:29,180 --> 00:56:34,080 +مقارنة التفويت، نتحدث عن مقارنة التفويت، ولكن الآن + +739 +00:56:34,080 --> 00:56:40,580 +مقارنة الميزة. ما يعني مقارنة الميزةنعم, one + +740 +00:56:40,580 --> 00:56:42,900 +divided by one minus the debt ratios. + +741 +00:56:46,620 --> 00:56:49,820 +فهو one divided by one minus the debt ratios. + +742 +00:56:53,000 --> 00:56:58,600 +ودفع دفع الدفع الدفع دفع دفع دفع دفع دفع دفع دفع + +743 +00:56:58,600 --> 00:56:58,620 +دفع دفع دفع دفع دفع دفع دفع دفع دفع دفع دفع دفع + +744 +00:56:58,620 --> 00:56:59,400 +دفع دفع دفع دفع دفع دفع دفع دفع دفع دفع دفع دفع + +745 +00:56:59,400 --> 00:57:05,560 +دفع دفع دفع دفع دفع دفع دفع + +746 +00:57:05,560 --> 00:57:14,440 +دOkay, total liabilities and equity Okay, + +747 +00:57:14,900 --> 00:57:20,860 +so now this is the equity multiplier The more debt + +748 +00:57:20,860 --> 00:57:24,940 +ratios that we have The more debt ratios that we + +749 +00:57:24,940 --> 00:57:29,400 +have The higher the equity multipliers or the more + +750 +00:57:29,400 --> 00:57:34,160 +equity multipliers For instance, if the debt ratio + +751 +00:57:34,160 --> 00:57:34,920 +is zero + +752 +00:57:38,450 --> 00:57:42,150 +الدت ريشو هو نصف، هذا يعني أننا لدينا واحدة + +753 +00:57:42,150 --> 00:57:47,630 +اقتصادية بدأت من واحدة و + +754 +00:57:47,630 --> 00:57:57,770 +أكثر الدتات اللي لدينا أكتر الدتات اللي لدينا أكتر + +755 +00:57:57,770 --> 00:58:01,050 +ABS أو فان فاليو + +756 +00:58:10,100 --> 00:58:17,780 +على سبيل المثال، لتحفز قيمة الشركة، يتم تحفز أو + +757 +00:58:17,780 --> 00:58:24,460 +تزيد قيمة الوظيفة وقد أشرحت هذا في تحفز الوظيفة + +758 +00:58:24,460 --> 00:58:32,240 +عندما نتحدث عن مقاومة الوظيفة نحن + +759 +00:58:32,240 --> 00:58:36,500 +نتحدث عن .. مقاومة الوظيفة هي مثل هذه، لدينا مصدر + +760 +00:58:37,730 --> 00:58:44,150 +وهنا لدينا كتابة لتضغط هذه الكتابة إذا كانت هذه + +761 +00:58:44,150 --> 00:58:52,470 +كتابة تقارن مع هذه كتابة + +762 +00:58:52,470 --> 00:58:55,570 +بحسب + +763 +00:58:55,570 --> 00:59:02,960 +الفيزياء في الفيزياء إذا قمنا بتضغط هذه الكتابةهذا + +764 +00:59:02,960 --> 00:59:08,980 +الوضع سيكون أقوى من هذا لأنه أكتر من هذا لذلك الـD + +765 +00:59:08,980 --> 00:59:19,100 +الوضع أكتر من الوضع هنا تعتبر الـD هنا مقالات و + +766 +00:59:19,100 --> 00:59:24,880 +تعتبر النبي نفس النبي هنا و EBS أيضًا النبي هنا + +767 +00:59:24,880 --> 00:59:31,850 +نفس النبي هنا لذلك القوة هي EBSالمزيد من الفرق + +768 +00:59:31,850 --> 00:59:35,530 +اللي لدينا، المزيد من الفرق اللي لدينا، المزيد من + +769 +00:59:35,530 --> 00:59:35,550 +الفرق اللي لدينا، المزيد من الفرق اللي لدينا، + +770 +00:59:35,550 --> 00:59:36,090 +المزيد من الفرق اللي لدينا، المزيد من الفرق اللي + +771 +00:59:36,090 --> 00:59:36,150 +لدينا، المزيد من الفرق اللي لدينا، المزيد من الفرق + +772 +00:59:36,150 --> 00:59:36,190 +الفرق اللي لدينا، المزيد من الفرق اللي لدينا، + +773 +00:59:36,190 --> 00:59:36,810 +المزيد من الفرق اللي لدينا، المزيد من الفرق اللي + +774 +00:59:36,810 --> 00:59:38,790 +لدينا، المزيد من الفرق اللي لدينا، المزيد من الفرق + +775 +00:59:38,790 --> 00:59:43,170 +اللي لدينا، المزيد + +776 +00:59:43,170 --> 00:59:46,870 +من الفرق اللي لدينا، المزيد + +777 +00:59:46,870 --> 00:59:51,230 +من الفرق + +778 +00:59:51,230 --> 00:59:53,790 +اللي لدينا، المزيد + +779 +00:59:57,510 --> 01:00:01,830 +في شركة ايه نحن نحن نحن نحن نحن نحن نحن نحن نحن + +780 +01:00:01,830 --> 01:00:02,850 +نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن + +781 +01:00:02,850 --> 01:00:04,130 +نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن + +782 +01:00:04,130 --> 01:00:07,050 +نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن + +783 +01:00:07,050 --> 01:00:07,290 +نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن + +784 +01:00:07,290 --> 01:00:08,770 +نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن نحن + +785 +01:00:08,770 --> 01:00:15,210 +نحن نحن + +786 +01:00:15,210 --> 01:00:21,200 +نحن نأو 700 and the debt the equity is 300 so we + +787 +01:00:21,200 --> 01:00:25,500 +have one million here we have 300 and 700 now + +788 +01:00:25,500 --> 01:00:30,300 +consider this case the profits the + +789 +01:00:30,300 --> 01:00:35,880 +profit is let's say one hundred dollar and here + +790 +01:00:35,880 --> 01:00:39,360 +one hundred dollarالان دعونا نقوم بتخطيط ال EBS + +791 +01:00:39,360 --> 01:00:45,320 +لكتير ال EBS يتم تخطيطه كـ Net Income Divided By + +792 +01:00:45,320 --> 01:00:48,980 +The Number Of Shares Outstanding Now ماهي ال net + +793 +01:00:48,980 --> 01:00:53,260 +income هنا هو 100 number of shares outstanding إذا + +794 +01:00:53,260 --> 01:01:01,200 +كان هذا قيمة أعلى هو 300 وهنا 100 مقاتل 700 ماهي + +795 +01:01:01,200 --> 01:01:10,500 +ال EBS هنا هو 33% ال EBS هنا 14%So in this case + +796 +01:01:10,500 --> 01:01:17,300 +the profit is the same but what is the .. the + +797 +01:01:17,300 --> 01:01:20,000 +difference is the capital structure وهي we depend + +798 +01:01:20,000 --> 01:01:23,560 +on more debts So what is the result? We end with + +799 +01:01:23,560 --> 01:01:31,020 +33 percent as ABSوهنا 14% كـ EBS إذا دفعنا 1 دولار + +800 +01:01:31,020 --> 01:01:36,640 +في هذه الشركة سنحصل على 33 سنة ولكن إذا دفعنا 1 + +801 +01:01:36,640 --> 01:01:43,300 +دولار هنا سنحصل على 14 سنة فهو + +802 +01:01:43,300 --> 01:01:49,420 +حسن للدفع لـ A لأننا قمنا بمعالجة الـ EBS أو قمنا + +803 +01:01:49,420 --> 01:01:55,000 +بمعالجة قيمة الـ FAM لماذا؟ لأن الدفعهذا السبب انه + +804 +01:01:55,000 --> 01:01:59,820 +مهم ان تضمن المال المعادل المعادل التي تعتبر المال + +805 +01:01:59,820 --> 01:02:03,000 +حسنا + +806 +01:02:03,000 --> 01:02:08,440 +فهذا هو السبب و أكتر ما نعتمد على المال أكتر ما + +807 +01:02:08,440 --> 01:02:15,060 +نحفزه حسنا دعونا نذهب هكذا اتغير هذه الوضعية بفعل + +808 +01:02:15,060 --> 01:02:23,200 +حسنا 100 مال و 900 مال لدينا 100 هنا + +809 +01:02:26,110 --> 01:02:32,710 +لذلك نحصل على 100% من الأرباح ، لذلك إذا كنت قمت + +810 +01:02:32,710 --> 01:02:35,930 +ببيع واحد دولار ، فنحصل على واحد دولار ، لكن + +811 +01:02:35,930 --> 01:02:41,050 +الأرباح مازالت نفسها ، لا تغيير في الأرباح ، لكن + +812 +01:02:41,050 --> 01:02:47,030 +المشكلة بهذا أنها تحفز الأرباح و تحفز الفوز ، إنها + +813 +01:02:47,030 --> 01:02:49,690 +تحافظ على ترتيب أعلى وفي نفس الوقت تحافظ على أعلى + +814 +01:02:49,690 --> 01:02:57,810 +أسرار ، إذا كنا نخسر 100$لذلك فالفكرة ستتغير، لذلك + +815 +01:02:57,810 --> 01:03:03,850 +نخسر هنا 100 او 1 دولار ونخسر فقط 13 او 14 سنة، + +816 +01:03:03,850 --> 01:03:11,170 +لذلك نفضل B على A بسبب مصطلح الكفة، حسنا؟ + +817 +01:03:14,040 --> 01:03:17,320 +هو كيف نقوم بالتخطيط للحصول على حصولة عملية عامة + +818 +01:03:17,320 --> 01:03:22,940 +بقية السعوانات ونقوم بالتحديث + +819 +01:03:22,940 --> 01:03:31,810 +عن نتيجة السعواناتالـ 22% هو الوصول من مرة 2.16 + +820 +01:03:31,810 --> 01:03:38,670 +مرة 1.37 مرة 7.6% نحن لدينا 22% بالمقارنة بالجماعة + +821 +01:03:38,670 --> 01:03:45,110 +العامة، شركة PassWell لديها إرجع أعلى على المال + +822 +01:03:45,110 --> 01:03:51,150 +لماذا؟ لأن الـ Net Profits إذا نظرنا إلى المجموعات + +823 +01:03:51,150 --> 01:03:56,760 +المجتمعة هي أعلىاستخدام السوق يكون أعلى من هذا، + +824 +01:03:56,760 --> 01:03:59,840 +ولكن مجموعة الناتس بروفت أقل من هذا، ولكن المشكلة + +825 +01:03:59,840 --> 01:04:04,260 +هي أن الـ equity multiplier يقوم بإعادة قيمة + +826 +01:04:04,260 --> 01:04:05,820 +الشركة، إعادة الاستثمار بالاستثمار بالاستثمار + +827 +01:04:05,820 --> 01:04:09,280 +بالاستثمار بالاستثمار بالاستثمار بالاستثمار + +828 +01:04:09,280 --> 01:04:10,400 +بالاستثمار بالاستثمار بالاستثمار بالاستثمار + +829 +01:04:10,400 --> 01:04:10,480 +بالاستثمار بالاستثمار بالاستثمار بالاستثمار + +830 +01:04:10,480 --> 01:04:11,100 +بالاستثمار بالاستثمار بالاستثمار بالاستثمار + +831 +01:04:11,100 --> 01:04:11,260 +بالاستثمار بالاستثمار بالاستثمار بالاستثمار + +832 +01:04:11,260 --> 01:04:14,800 +بالاستثمار بالاستثمار بالاستثمار بالا + +833 +01:04:17,300 --> 01:04:19,960 +Okay we stop here to talk about the market value + +834 +01:04:19,960 --> 01:04:25,240 +ratios next meeting okay this is the last one or + +835 +01:04:25,240 --> 01:04:28,740 +the last meeting in the chapter four okay + +836 +01:04:28,740 --> 01:04:30,720 +Inshallah see you Inshallah on Wednesday + diff --git a/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/DyGvjx_0RPg_raw.json b/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/DyGvjx_0RPg_raw.json new file mode 100644 index 0000000000000000000000000000000000000000..317b32c3f1fe4595e5d903e936d1b9f687090c3d --- /dev/null +++ b/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/DyGvjx_0RPg_raw.json @@ -0,0 +1 @@ +{"segments": [{"id": 1, "seek": 4765, "start": 18.51, "end": 47.65, "text": "بسم الله الرحمن الرحيم اللي قال فات we talk about the cash flow statements and the main parts of the cash flow الأجزاء الرئاسية في ال cash flow في ال cash .. the cash flow statement includes three main steps the first one cash flow from operating cash flow from investing cash flow from financing then you have the in the cash flow balance just I'm revising the cash flow 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بالعودة ومشاركته + +8 +00:00:43,320 --> 00:00:46,420 +بالعودة ومشاركته بالعودة ومشاركته بالعودة ومشار + +9 +00:00:47,450 --> 00:00:58,390 +وأشياء أخرى مرتبطة بالسوق الاجتماعي، حسنا؟ لتعرف + +10 +00:00:58,390 --> 00:01:01,790 +الأهداف، الأساسيات المستخدمة في هذه القصة، الأول + +11 +00:01:01,790 --> 00:01:05,370 +شيء هو التخطيط من الواقع ورسالة الترجمة المتوقعة، + +12 +00:01:05,370 --> 00:01:10,130 +لذلك يجب أن تختار ما يعني رسالة الترجمة المتوقعة + +13 +00:01:10,130 --> 00:01:16,130 +وما يعني رسالة الترجمة المتوقعة، وخطوات مختلفة من + +14 +00:01:16,130 --> 00:01:20,740 +الرسالةوفي نفس الوقت، يجب أن يكون هناك علاقة بين + +15 +00:01:20,740 --> 00:01:26,020 +الضرر والعادة.الأساس + +16 +00:01:26,020 --> 00:01:29,460 +الثاني، أو الأساس الثاني، يشير إلى أساسية تاريخية + +17 +00:01:29,460 --> 00:01:33,240 +محافظات المحافظات المالية، فسنتحدث عن محافظة + +18 +00:01:33,240 --> 00:01:39,640 +الولايات المتحدة، محافظة البحر، ومحافظة التطوروأرى + +19 +00:01:39,640 --> 00:01:45,840 +وأقارب بينهم وخيرًا سنتحدث عن مقاومة الترجمة التي + +20 +00:01:45,840 --> 00:01:49,000 +هي مقارنة جيومترية ضد عملية عملية عملية عملية + +21 +00:01:49,000 --> 00:01:50,300 +عملية عملية عملية عملية عملية عملية عملية عملية + +22 +00:01:50,300 --> 00:01:51,680 +عملية عملية عملية عملية عملية عملية عملية عملية + +23 +00:01:51,680 --> 00:01:52,560 +عملية عملية عملية عملية عملية عملية عملية عملية + +24 +00:01:52,560 --> 00:01:52,700 +عملية عملية عملية عملية عملية عملية عملية عملية + +25 +00:01:52,700 --> 00:01:54,700 +عملية عملية عملية عملية عملية عملية عملية عملية + +26 +00:01:54,700 --> 00:01:59,010 +عمليestimate the geometric and the arithmetic and + +27 +00:01:59,010 --> 00:02:02,810 +they have a question in the exam about the + +28 +00:02:02,810 --> 00:02:07,670 +geometric and arithmetic okay so this is the + +29 +00:02:07,670 --> 00:02:12,830 +principles and we'll talk about the hypothesis of + +30 +00:02:12,830 --> 00:02:16,170 +market efficiency what it means market efficiency + +31 +00:02:16,170 --> 00:02:18,670 +and what is the implication of the market + +32 +00:02:18,670 --> 00:02:24,630 +efficiencyوفي النهاية سنتحدث عن أسلحة المفروضة + +33 +00:02:24,630 --> 00:02:30,310 +التي موجودة في هذه القصة القصة المستخدمة في هذه + +34 +00:02:30,310 --> 00:02:37,390 +القصة هي تغيير الهجوم والإعادة وسنتحدث عن هذا في + +35 +00:02:37,390 --> 00:02:41,630 +القصة الأولى قصة نمبر واحدة قصة نمبر أربعة قصة + +36 +00:02:41,630 --> 00:02:42,950 +نمبر واحدة قصة نمبر واحد قصة نمبر واحد قصة نمبر + +37 +00:02:42,950 --> 00:02:43,070 +واحد قصة نمبر واحد قصة نمبر واحد قصة نمبر واحد قصة + +38 +00:02:43,070 --> 00:02:43,670 +نمبر واحد قصة نمبر واحد قصة نمبر واحد قصة نمبر + +39 +00:02:43,670 --> 00:02:44,290 +واحد قصة نمبر واحد قصة نمبر واحد قصة نمبر واحد قصة + +40 +00:02:44,290 --> 00:02:50,390 +نمبر واحد قصة نمبر واحد قصة نمبرالان ماهي قيمة + +41 +00:02:50,390 --> 00:02:54,070 +الوصول وماهي قيمة الوصول المتوقعة وماهي المخاطر + +42 +00:02:55,550 --> 00:03:03,710 +تحاول ان تفهم الفرق بين الواقعي والمتوقع حسنا، + +43 +00:03:03,710 --> 00:03:07,390 +ماهو الواقع؟ الواتر الواقع أو الواتر المالي يقوم + +44 +00:03:07,390 --> 00:03:13,030 +بإيقاف أو خسارة مستخدم، هذا الواقع هو حجم الواتر + +45 +00:03:13,030 --> 00:03:16,470 +الحقيقي، أنا أتكلم عن حجم الواتر الحقيقي، على سبيل + +46 +00:03:16,470 --> 00:03:24,500 +المثال، إذا شاءت أنك شتت شركة بالتيلهل تعرفين + +47 +00:03:24,500 --> 00:03:31,760 +بالتل؟ إذا شركة بالتل شركة بالتل قامت بشرقة بالتل + +48 +00:03:31,760 --> 00:03:39,360 +بقيمة 7.5 دولار يوم السابق و اليوم هي 7 دولار فهذا + +49 +00:03:39,360 --> 00:03:45,520 +يوم السابق و هذا اليوم و تعتبر أنه لا يوجد مجموعة + +50 +00:03:45,520 --> 00:03:51,120 +من المال لا يوجد تدفع تدفع تدفع ماذا يعني تدفع؟ + +51 +00:03:51,120 --> 00:03:57,240 +تدفع يعني دفعاتبالتالي، لا يوجد إخراج، فهي نقطة. + +52 +00:03:57,280 --> 00:04:00,040 +فما هي عادة المال؟ + +53 +00:04:04,520 --> 00:04:09,960 +ماذا هو الـ cash-return؟ حسنا، 7 دولار، ماذا؟ سعر + +54 +00:04:09,960 --> 00:04:16,060 +السحب، اضافة إلى 0، لسنا لدينا دفعات، اضافة إلى + +55 +00:04:16,060 --> 00:04:21,540 +سعر السحب، 6.5، فالـ cash-return في هذه الحالة هو + +56 +00:04:21,540 --> 00:04:33,360 +0.5 دولار، حسنا؟ تعتبر بالتل 0.25 + +57 +00:04:35,520 --> 00:04:39,060 +$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$ + +58 +00:04:39,060 --> 00:04:48,360 +$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$ + +59 +00:04:48,360 --> 00:04:52,240 +$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$ + +60 +00:04:52,240 --> 00:04:52,240 +$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$ + +61 +00:04:52,240 --> 00:05:00,100 +$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$$ + +62 +00:05:00,100 --> 00:05:01,760 +$$$ + +63 +00:05:05,450 --> 00:05:09,270 +فقط قمت بتقسيم هذه المقارنة بمقارنة هذه المقارنة + +64 +00:05:09,270 --> 00:05:18,650 +فقط قمت بتقسيمها بمقارنة السعر الأول فقط + +65 +00:05:18,650 --> 00:05:29,470 +لكي أسمح لكم أن عادة المال هي نفس السعر النهائي P1 + +66 +00:05:29,470 --> 00:05:34,530 +او Pout + +67 +00:05:35,560 --> 00:05:43,640 +-B0 هو الأسعار وانتبه ان هذا دولار ودولار ودولار + +68 +00:05:43,640 --> 00:05:44,080 +ودولار ودولار ودولار ودولار ودولار ودولار ودولار + +69 +00:05:44,080 --> 00:05:46,580 +ودولار ودولار ودولار ودولار ودولار ودولار ودولار + +70 +00:05:46,580 --> 00:05:46,760 +ودولار ودولار ودولار ودولار ودولار ودولار ودولار + +71 +00:05:46,760 --> 00:05:46,840 +ودولار ودولار ودولار ودولار ودولار ودولار ودولار + +72 +00:05:46,840 --> 00:05:48,380 +ودولار ودولار ودولار ودولار ودولار ودولار ودولار + +73 +00:05:48,380 --> 00:05:50,080 +ودولار ودولار ودولار ودولار ودولار ودولار ودولار + +74 +00:05:50,080 --> 00:06:00,280 +ودولار ودولار ودولار ودولار ودولار ودولار ودولار + +75 +00:06:00,280 --> 00:06:01,600 +ود + +76 +00:06:04,190 --> 00:06:09,450 +هذا هو المشكلة المشكلة المشكلة المشكلة المشكلة + +77 +00:06:09,450 --> 00:06:11,050 +المشكلة المشكلة المشكلة المشكلة المشكلة المشكلة + +78 +00:06:11,050 --> 00:06:12,030 +المشكلة المشكلة المشكلة المشكلة المشكلة المشكلة + +79 +00:06:12,030 --> 00:06:14,970 +المشكلة المشكلة المشكلة المشكلة المشكلة المشكلة + +80 +00:06:14,970 --> 00:06:17,250 +المشكلة المشكلة المشكلة المشكلة المشكلة المشكلة + +81 +00:06:17,250 --> 00:06:17,410 +المشكلة المشكلة المشكلة المشكلة المشكلة المشكلة + +82 +00:06:17,410 --> 00:06:17,410 +المشكلة المشكلة المشكلة المشكلة المشكلة المشكلة + +83 +00:06:17,410 --> 00:06:17,410 +المشكلة المشكلة المشكلة المشكلة المشكلة المشكلة + +84 +00:06:17,410 --> 00:06:21,310 +المشكلة المشكلة المشكلة المشكلة المشكلة المشكلة + +85 +00:06:21,310 --> 00:06:24,590 +المشكلة المشكلة الم + +86 +00:06:36,880 --> 00:06:42,660 +تأخذ هذا المثال هنا، انت شرحت في شركة أبل، هل + +87 +00:06:42,660 --> 00:06:50,560 +تعرفين أبل؟ لـ 95 دولار و قبل عام 200 دولار، لم + +88 +00:06:50,560 --> 00:06:54,780 +تدفع الشركة أي دفعات في ذلك الوقت، ماذا سيكون عدد + +89 +00:06:54,780 --> 00:06:58,960 +الدفعات على هذه الدفعات؟ حاولي ان تفعلها، نريد عدد + +90 +00:06:58,960 --> 00:07:01,360 +الدفعات، ماهو عدد الدفعات؟ + +91 +00:07:07,480 --> 00:07:11,620 +بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس + +92 +00:07:11,620 --> 00:07:14,100 +بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس + +93 +00:07:14,100 --> 00:07:17,020 +بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس + +94 +00:07:17,020 --> 00:07:18,260 +بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس + +95 +00:07:18,260 --> 00:07:18,260 +بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس + +96 +00:07:18,260 --> 00:07:18,260 +بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس بس + +97 +00:07:18,260 --> 00:07:24,200 +بس بس بس بس بس بس بس بس بس بس + +98 +00:07:42,540 --> 00:07:52,700 +105 وانت ترى 105 حسنا نستطيع ان نتكلم عن قيمة الـ + +99 +00:07:52,700 --> 00:07:57,860 +10 حاول ان تتكلم عن قيمة الـ 10 1 + +100 +00:07:57,860 --> 00:08:02,600 +.1 1.1 + +101 +00:08:02,600 --> 00:08:04,320 +هل انت متأكد؟ حسنا + +102 +00:08:07,200 --> 00:08:10,660 +one point one one point one one point one one + +103 +00:08:10,660 --> 00:08:11,460 +point one point one point one point one point one + +104 +00:08:11,460 --> 00:08:11,680 +point one point one point one point one point one + +105 +00:08:11,680 --> 00:08:11,700 +point one point one point one point one point one + +106 +00:08:11,700 --> 00:08:11,720 +point one point one point one point one point one + +107 +00:08:11,720 --> 00:08:11,800 +point one point one point one point one point one + +108 +00:08:11,800 --> 00:08:12,700 +point one point one point one point one point one + +109 +00:08:12,700 --> 00:08:12,700 +point one point one point one point one point one + +110 +00:08:12,700 --> 00:08:12,760 +point one point one point one point one point one + +111 +00:08:12,760 --> 00:08:12,760 +point one point one point one point one point one + +112 +00:08:12,760 --> 00:08:12,760 +point one point one point one point one point one + +113 +00:08:12,760 --> 00:08:18,120 +point one point one point one point one point one + +114 +00:08:18,120 --> 00:08:18,120 +point one point one point one point one point one + +115 +00:08:18,120 --> 00:08:18,120 +point one point one point one point one point one + +116 +00:08:18,120 --> 00:08:18,300 +point one point one point one point one point one + +117 +00:08:18,300 --> 00:08:18,300 +point one point one point one point one point one + +118 +00:08:18,300 --> 00:08:19,760 +point one point one point one point one point one + +119 +00:08:19,760 --> 00:08:21,320 +point one point one point one point one point one + +120 +00:08:21,320 --> 00:08:22,180 +point one point one point one point one point one + +121 +00:08:22,180 --> 00:08:24,940 +point one point one point one point one point one + +122 +00:08:24,940 --> 00:08:24,940 +point one point one point one point one point one + +123 +00:08:24,940 --> 00:08:26,900 +point one point one point one point one point one + +124 +00:08:26,900 --> 00:08:31,380 +point one point one + +125 +00:08:32,290 --> 00:08:35,370 +So this is two hundred minus ninety five divided + +126 +00:08:35,370 --> 00:08:45,410 +by ninety five then this is the answer this is why + +127 +00:08:45,410 --> 00:08:51,230 +I say are you sure okay so the result should be as + +128 +00:08:51,230 --> 00:08:51,610 +a percent + +129 +00:08:57,870 --> 00:09:00,730 +انظر إلى الطابق السادسة واحد في الطابق السادسة + +130 +00:09:00,730 --> 00:09:04,870 +واحد سنجد بعض الأمثلة عن كيفية تخطيط عدسة العودة + +131 +00:09:04,870 --> 00:09:09,090 +الواقعية عدسة العودة الواقعية عدسة عدسة عدسة عدسة + +132 +00:09:09,090 --> 00:09:10,230 +عدسة عدسة عدسة عدسة عدسة عدسة عدسة عدسة عدسة عدسة + +133 +00:09:10,230 --> 00:09:12,710 +عدسة عدسة عدسة عدسة عدسة عدسة عدسة عدسة عدسة عدسة + +134 +00:09:12,710 --> 00:09:13,230 +عدسة عدسة عدسة عدسة عدسة عدسة عدسة عدسة عدسة عدسة + +135 +00:09:13,230 --> 00:09:23,010 +عدسة عدسة عدسة عدسة عدسة عد + +136 +00:09:23,940 --> 00:09:29,320 +ووالماردز هذا هو السعر الأول في القسم A وهذا هو + +137 +00:09:29,320 --> 00:09:33,860 +السعر النهائي وهناك دفعة مالية وهذا هو العدالة + +138 +00:09:33,860 --> 00:09:38,740 +نتخيل العدالة باسم دولار عدالة دولار ورق عدالة + +139 +00:09:38,740 --> 00:09:45,300 +عدالة عدالة عدالة عدالة + +140 +00:09:45,300 --> 00:09:45,400 +عدالة عدالة عدالة عدالة عدالة عدالة عدالة عدالة + +141 +00:09:53,690 --> 00:09:59,290 +هذه الجمهور و هذه الجمهور تفعيل ال CS واحد و + +142 +00:09:59,290 --> 00:10:05,290 +المدرسة في النهاية تحاول تفعيل ال Walmart للمدرسة + +143 +00:10:05,290 --> 00:10:15,930 +تحاول تفعيل أفضلك تعال هنا انها + +144 +00:10:15,930 --> 00:10:20,650 +فقط بسيطة جدا لتفعيل هذاOkay and you don't need to + +145 +00:10:20,650 --> 00:10:35,230 +see this these answers okay okay + +146 +00:10:35,230 --> 00:10:36,870 +so no answers + +147 +00:10:50,340 --> 00:10:55,860 +السعر الانتقالي هو السعر الذي اشترينا السوق والسعر + +148 +00:10:55,860 --> 00:11:01,680 +الانتقالي هو السعر الذي اشترينا السوق والسعر + +149 +00:11:01,680 --> 00:11:03,540 +الانتقالي هو السعر الانتقالي هو السعر الانتقالي هو + +150 +00:11:03,540 --> 00:11:03,540 +السعر الانتقالي هو السعر الانتقالي هو السعر + +151 +00:11:03,540 --> 00:11:03,540 +الانتقالي هو السعر الانتقالي هو السعر الانتقالي هو + +152 +00:11:03,540 --> 00:11:05,160 +السعر الانتقالي هو السعر الانتقالي هو السعر + +153 +00:11:05,160 --> 00:11:08,560 +الانتقالي هو السعر الانتقالي هو السعر الانتقالي هو + +154 +00:11:08,560 --> 00:11:10,920 +السعر الانتقالي هو السعر الانتقالي هو السعر + +155 +00:11:10,920 --> 00:11:18,160 +الانتقالي هو السعر الانتقالي هو السعر الانتقاليلا + +156 +00:11:18,160 --> 00:11:23,020 +لا في الاجامعات لا تحتاج هذه الوقت حسنا + +157 +00:11:23,020 --> 00:11:27,700 +حسنا دعنا نبدأ من الجمهور الأول من هنا ماذا عن + +158 +00:11:27,700 --> 00:11:32,340 +الجمهور الأول الشركة الأولة الدولار الواطن ماهو + +159 +00:11:32,340 --> 00:11:38,700 +الدولار الواطن تلاتة اتس كمان خطأ كمان كمان كمان + +160 +00:11:38,700 --> 00:11:41,380 +كمان كمان كمان كمان كمان كمان كمان كمان كمان كمان + +161 +00:11:41,380 --> 00:11:44,620 +كمان كمان كمان كمان كمان كمان كمان كمان كمان كمان + +162 +00:11:44,620 --> 00:11:45,100 +كمان كمان كمان كمان كمان كمان كمان كمان كمان كمان + +163 +00:11:45,100 --> 00:11:45,140 +كمان كمان كمان كمان كمان كمان كمان كمان كمان كمان + +164 +00:11:45,140 --> 00:11:49,770 +كمان كمان كمان كمانعن طريق النهاية .. نهاية .. + +165 +00:11:49,770 --> 00:11:56,470 +أكتر من هذا .. أكتر من هذا .. أكتر من هذا .. أكتر + +166 +00:11:56,470 --> 00:11:58,010 +من هذا .. أكتر من هذا .. أكتر من هذا .. أكتر من + +167 +00:11:58,010 --> 00:11:58,010 +هذا .. أكتر من هذا .. أكتر من هذا .. أكتر من هذا + +168 +00:11:58,010 --> 00:11:58,470 +.. أكتر من هذا .. أكتر من هذا .. أكتر من هذا .. + +169 +00:11:58,470 --> 00:12:00,370 +أكتر من هذا .. أكتر من هذا .. أكتر من هذا .. أكتر + +170 +00:12:00,370 --> 00:12:02,470 +من هذا .. أكتر من هذا .. أكتر من هذا .. أكتر من + +171 +00:12:02,470 --> 00:12:03,470 +هذا .. أكتر من هذا .. أكتر من هذا .. أكتر من هذا + +172 +00:12:03,470 --> 00:12:03,970 +.. أكتر من هذا .. أكتر من هذا .. أكتر من هذا .. + +173 +00:12:03,970 --> 00:12:07,530 +أكتر من هذا .. أكتر من هذا .. أكتر من هذا .. أكتر + +174 +00:12:07,530 --> 00:12:15,270 +من + +175 +00:12:15,270 --> 00:12:21,450 +هذا .. أنرى الثاني نعم + +176 +00:12:21,450 --> 00:12:25,510 +نعم نعم + +177 +00:12:25,510 --> 00:12:30,410 +نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم + +178 +00:12:30,410 --> 00:12:31,310 +نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم + +179 +00:12:31,310 --> 00:12:32,730 +نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم + +180 +00:12:32,730 --> 00:12:32,730 +نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم + +181 +00:12:32,730 --> 00:12:32,730 +نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم + +182 +00:12:32,730 --> 00:12:32,750 +نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم + +183 +00:12:32,750 --> 00:12:32,750 +نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم + +184 +00:12:32,750 --> 00:12:34,870 +نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم + +185 +00:12:34,870 --> 00:12:39,650 +نعم نعم نعم نعم نعم نعم نعم نعم نعم ن + +186 +00:12:41,600 --> 00:12:48,000 +مع الدفع الماضي يعني حوالي 16 17 مانا 16 مانا 16 + +187 +00:12:48,000 --> 00:12:49,820 +مانا 16 مانا 16 مانا 16 مانا 16 مانا 16 مانا 16 + +188 +00:12:49,820 --> 00:12:51,680 +مانا 16 مانا 16 مانا 16 مانا 16 مانا 16 مانا 16 + +189 +00:12:51,680 --> 00:12:53,740 +مانا 16 مانا 16 مانا 16 مانا 16 مانا 16 مانا 16 + +190 +00:12:53,740 --> 00:12:53,740 +مانا 16 مانا 16 مانا 16 مانا 16 مانا 16 مانا 16 + +191 +00:12:53,740 --> 00:12:53,780 +مانا 16 مانا 16 مانا 16 مانا 16 مانا 16 مانا 16 + +192 +00:12:53,780 --> 00:12:53,820 +مانا 16 مانا 16 مانا 16 مانا 16 مانا 16 مانا 16 + +193 +00:12:53,820 --> 00:12:53,860 +مانا 16 مانا 16 مانا 16 مانا 16 مانا 16 مانا 16 + +194 +00:12:53,860 --> 00:12:55,340 +مانا 16 مانا 16 مانا 16 مانا 16 مانا 16 مانا 16 + +195 +00:12:55,340 --> 00:13:02,100 +مانا 16 مانا + +196 +00:13:02,100 --> 00:13:06,680 +16 + +197 +00:13:07,370 --> 00:13:16,490 +Okay the third yes say + +198 +00:13:16,490 --> 00:13:20,710 +it + +199 +00:13:20,710 --> 00:13:26,050 +again the result the dollar return no no tell me + +200 +00:13:26,050 --> 00:13:31,240 +the dollar return what is the dollar returnyes you + +201 +00:13:31,240 --> 00:13:36,020 +are right and the red is 94 yes excellent okay so + +202 +00:13:36,020 --> 00:13:48,040 +we have this it's fine and this group yes are you + +203 +00:13:48,040 --> 00:13:55,740 +sure yes are you sure yes okay carry on 17 + +204 +00:13:55,740 --> 00:14:04,510 +.5 17 or 70سبنتين سبنتين yes okay + +205 +00:14:04,510 --> 00:14:12,190 +so seventeen your rights okay at the end at the + +206 +00:14:12,190 --> 00:14:19,870 +end people at the end okay so I know because they + +207 +00:14:19,870 --> 00:14:26,640 +coming they came late so it cost themعلى أية حال + +208 +00:14:26,640 --> 00:14:35,980 +فقط لدينا النهارة 49 plus 1 يعني حوالي 50 شيء مقصد + +209 +00:14:35,980 --> 00:14:42,960 +55 مقصد فهو مقصد مقصد 5 مقصد و 9 مقصد 9% هذه هي + +210 +00:14:42,960 --> 00:14:47,560 +السرعة التي حصلت عليها هذا بسيط جدا ولكن أقترحك أن + +211 +00:14:47,560 --> 00:14:53,120 +تدرس نفسك على هذا لأن كل شيء مخصص لانه لا يأخذ وقت + +212 +00:14:53,120 --> 00:15:07,970 +كبير في فعل هذاbig analysis okay so let's + +213 +00:15:07,970 --> 00:15:14,770 +go back to the to + +214 +00:15:14,770 --> 00:15:18,730 +here you have any question in this okay + +215 +00:15:23,700 --> 00:15:31,700 +ما نشاهده في الـ Table 7-1 نشاهد أنه يمكن أن يكون + +216 +00:15:31,700 --> 00:15:37,220 +في نقل ويمكن أن يكون في اضافة كما نشاهده في شركة + +217 +00:15:37,220 --> 00:15:43,140 +والمارتز ويستمتع + +218 +00:15:43,140 --> 00:15:46,500 +بمعادلة المستخدام الممكن للعودة حيث كل مستخدم + +219 +00:15:46,500 --> 00:15:50,480 +الممكن للعودة يتواجد بمعادلة المستخدام + +220 +00:15:52,390 --> 00:15:57,470 +التجارب السابقة ليست إشارة لتجارب المستقبل، إذا + +221 +00:15:57,470 --> 00:16:03,650 +عدت إلى هنا، يظن بعض الناس أن الأسعار مع أسعار + +222 +00:16:03,650 --> 00:16:07,850 +أعلى هي أفضل المستخدمين، وهو غير صحيح تمامًا. + +223 +00:16:12,300 --> 00:16:20,800 +مثل هذه الأسعار 37 دولار أو 15 دولار و تجعلها 45% + +224 +00:16:20,800 --> 00:16:25,740 +فهذا لا يعني أن السعر هو إشارة جيدة إذا كانت + +225 +00:16:25,740 --> 00:16:31,220 +الشركة مستفيدة أو لا الجسم الكبير ليس إشارة للوضع + +226 +00:16:31,220 --> 00:16:36,980 +الصحيح لذلك تفكر في هذه الوضعية انظر إلى السعر لأن + +227 +00:16:36,980 --> 00:16:45,380 +السعر ربما مخطئ أو مخطئالان نعرف ماذا يعني إعادة + +228 +00:16:45,380 --> 00:16:51,640 +الوصول الواقعي الواقعي + +229 +00:16:51,640 --> 00:16:58,200 +هو الواقع الواقعي لكن الواقع الواقعي هو ما تتوقعه + +230 +00:16:58,200 --> 00:17:06,820 +كبار المستخدمين فقط لكي أكتشف + +231 +00:17:10,350 --> 00:17:19,930 +إذا سعر الـ Paletel الان هو 6.5 دولار، هذا هو + +232 +00:17:19,930 --> 00:17:24,410 +السعر الحقيقي أو السعر الحقيقي أو السعر الحقيقي، + +233 +00:17:24,410 --> 00:17:28,270 +الآن ما تتوقعه، ما تتوقعه هو السعر، هل هذا السعر + +234 +00:17:28,270 --> 00:17:33,910 +الحقيقي يتفضل مع حالة الشركة الحقيقية أو لا؟ هذه + +235 +00:17:33,910 --> 00:17:37,510 +هي السؤال دعونا نأخذ 2 شخص هنا + +236 +00:17:40,590 --> 00:17:48,190 +و هذا الشخص ينظر إلى هذا السعر هذا + +237 +00:17:48,190 --> 00:17:53,630 +الشخص لا ينظر إلى السعر هو عاد إلى السعر ولكنه غير + +238 +00:17:53,630 --> 00:17:59,490 +معلوم غير معلوم لا يعرف أي شيء عن السعر هو ينظر + +239 +00:17:59,490 --> 00:18:05,070 +إلى أشياء أخرى ولكنه جديد في السوق لذلك لايوجد + +240 +00:18:05,070 --> 00:18:12,340 +معلومات عن السعرSo if he or she expect the price + +241 +00:18:12,340 --> 00:18:18,820 +what do you think؟ he can expect the price close + +242 +00:18:18,820 --> 00:18:23,420 +to the real price or not؟ we don't know okay for + +243 +00:18:23,420 --> 00:18:26,200 +instance he may expect the price could be seven + +244 +00:18:26,200 --> 00:18:32,200 +but this guy he has experienceأو لديها تجربة + +245 +00:18:32,200 --> 00:18:38,000 +فالسعر ربما قريب جدا من السعر الحقيقي أو تجارب + +246 +00:18:38,000 --> 00:18:44,300 +العمل الحقيقية يمكن أن يكون 6.6.6.6.6.6.6.6.6.6.6 + +247 +00:18:44,300 --> 00:18:48,180 +.6.6.6 + +248 +00:18:48,180 --> 00:18:49,280 +.6.6.6.6.6.6.6.6.6.6.6.6.6.6.6.6.6.6.6.6.6.6.6.6.6 + +249 +00:18:49,280 --> 00:18:49,800 +.6.6.6.6.6.6.6.6.6.6.6.6.6.6.6.6.6.6.6.6.6.6.6.6.6 + +250 +00:18:49,800 --> 00:18:53,820 +.6.6.6.6.6.6.6.6.6.6.6.6.6.6.6.6.6.6.6.6.6.6.6 + +251 +00:18:53,820 --> 00:18:59,040 +.6 + +252 +00:18:59,040 --> 00:19:07,980 +.6.السعر هو 6.C6.O3 في هذه الحالة، هذا الرحل + +253 +00:19:07,980 --> 00:19:15,340 +المعلق لديه فهم أفضل أو أقرار أفضل للسعر من هذا + +254 +00:19:15,340 --> 00:19:22,240 +الشخص ما هي القصة هنا؟ القصة هي أكتر أنك معلق، + +255 +00:19:22,240 --> 00:19:32,950 +أكتر ..السعر المتوقع قريب من السعر الحقيقي. أكيد + +256 +00:19:32,950 --> 00:19:36,590 +أكيد أكيد أكيد أكيد أكيد أكيد أكيد أكيد أكيد أكيد + +257 +00:19:36,590 --> 00:19:38,510 +أكيد أكيد أكيد أكيد أكيد أكيد أكيد أكيد أكيد أكيد + +258 +00:19:38,510 --> 00:19:38,530 +أكيد أكيد أكيد أكيد أكيد أكيد أكيد أكيد أكيد أكيد + +259 +00:19:38,530 --> 00:19:40,530 +أكيد أكيد أكيد أكيد أكيد أكيد أكيد أكيد أكيد أكيد + +260 +00:19:40,530 --> 00:19:41,010 +أكيد أكيد أكيد أكيد أكيد أكيد أكيد أكيد أكيد أكيد + +261 +00:19:41,010 --> 00:19:43,730 +أكيد أكيد أكيد أكيد أكيد أكيد أكيد أكيد أكيد أكيد + +262 +00:19:43,730 --> 00:19:51,430 +أكيد أكيد أكيد أكيد أكيد أكيد أكيد + +263 +00:19:51,430 --> 00:19:59,090 +أالمزيد من الناس غير معلومين في السوق، المزيد منهم + +264 +00:19:59,090 --> 00:20:05,030 +غير متأكدين أو غير مفيدين من السعر، فهو يعتمد على + +265 +00:20:05,030 --> 00:20:09,870 +من يتحكم في السوق، المستخدمين غير معلومين أو غير + +266 +00:20:09,870 --> 00:20:12,830 +مستخدمين غير معلومين، فإذا كان لدينا مستخدمين غير + +267 +00:20:12,830 --> 00:20:17,230 +معلومين مع المعلومات الخاصة، ففي هذه الحالة، السعر + +268 +00:20:17,230 --> 00:20:21,370 +المتوقع هو قريب من السعر الحقيقي أو السعر الواقعي + +269 +00:20:24,120 --> 00:20:30,780 +حسنًا، هذه هي القصة عن كيف نستطيع أن نتوقع أو + +270 +00:20:30,780 --> 00:20:36,920 +نتكلم عن السعر المتوقع قبل + +271 +00:20:36,920 --> 00:20:43,300 +أن نتكلم عن هذا، دعنا نجرح ما قلته من وجهة المقاطع + +272 +00:20:43,300 --> 00:20:47,320 +هذا + +273 +00:20:47,320 --> 00:20:50,700 +المقاطع، هذا هو الوقت T + +274 +00:20:53,810 --> 00:21:00,090 +وهذا هو السعر، نشاهد السعر في الـ Paris Science + +275 +00:21:00,090 --> 00:21:04,870 +Exchange أو أي مؤتمر وفي + +276 +00:21:04,870 --> 00:21:09,250 +اليوم الأول نشاهد السعر هنا وفي اليوم الثاني نشاهد + +277 +00:21:09,250 --> 00:21:12,630 +السعر هنا وفي اليوم الثالث هو هنا وفي اليوم الرابع + +278 +00:21:12,630 --> 00:21:14,050 +وكذلك في أيام أخرى + +279 +00:21:17,080 --> 00:21:26,000 +ولذلك، السعر يتفلق مثل هذا يتفلق + +280 +00:21:26,000 --> 00:21:32,380 +مثل هذا، هذا هو السعر هذا حقيقي لأننا نلاحظ هذا + +281 +00:21:32,380 --> 00:21:41,760 +خلف هذا هذا ما في السوق ولكن إذا كنا نرغب في + +282 +00:21:41,760 --> 00:21:48,070 +التخطيط للشخص المتوقع الشخص المتوقع مثل هذاهذا هو + +283 +00:21:48,070 --> 00:21:53,790 +المتوقع نحن سنحاول أن نتوقع أن السعر موجود في هذه + +284 +00:21:53,790 --> 00:21:57,330 +المنطقة فهذه + +285 +00:21:57,330 --> 00:22:02,810 +المنطقة معروفة كخطأ المنطقة + +286 +00:22:02,810 --> 00:22:09,850 +من هنا إلى هنا هي خطأ وهنا + +287 +00:22:09,850 --> 00:22:12,750 +لدينا خطأ وهنا لدينا خطأ + +288 +00:22:17,170 --> 00:22:20,370 +ويمكننا التخيل هذا باستخدام الـ Variance أو الـ + +289 +00:22:20,370 --> 00:22:26,310 +Sigma أو أشياء أخرى من المخاطر في + +290 +00:22:26,310 --> 00:22:29,750 +هذا السوق، نعتبر هناك علاقة بين المتعرفين في هذه + +291 +00:22:29,750 --> 00:22:32,110 +الأسواق ولمتعرفين في هذه الأسواق، ولكننا لا نعرفها + +292 +00:22:32,110 --> 00:22:36,850 +دعونا نأخذ مقارنة أخرى لنقارن بين اتين مقارنتين + +293 +00:22:36,850 --> 00:22:41,730 +هذا في .. دعونا نقول في باريستان Stock Exchange + +294 +00:22:41,730 --> 00:22:43,870 +دعونا نرى في مؤتمرات أخرى + +295 +00:22:51,850 --> 00:22:54,670 +في اليوم الأول، اليوم الثاني، اليوم الثالث وكذلك + +296 +00:22:54,670 --> 00:23:02,590 +نأخذ هذه الملاحظة و + +297 +00:23:02,590 --> 00:23:08,250 +.. + +298 +00:23:08,250 --> 00:23:18,830 +حسنا دعونا نرى فهذا + +299 +00:23:18,830 --> 00:23:28,530 +هو السعر الحقيقيو سنلاحظ الـ expected الـ expected + +300 +00:23:28,530 --> 00:23:37,450 +هو مثل هذا، انظر الخطأ دعونا نرى ان هذا في جوردان، + +301 +00:23:37,450 --> 00:23:43,910 +هذا محافظة شركة شرق او جوردان، فقط نقارن بين اتين + +302 +00:23:43,910 --> 00:23:44,630 +شركات مدينة + +303 +00:23:48,250 --> 00:23:53,830 +هذا هو الخطأ وهذا هو الخطأ، ماذا تعتقدين بالمقارنة + +304 +00:23:53,830 --> 00:23:58,930 +بين هذه السوق وهذه السوق؟ + +305 +00:23:58,930 --> 00:24:03,990 +هذه السوق غير مفيدة، لا تتجاوز قيمتها بالمقارنة مع + +306 +00:24:03,990 --> 00:24:08,770 +ال .. أجل أجل أجل أجل أجل أجل أجل أجل أجل أجل أجل + +307 +00:24:08,770 --> 00:24:08,910 +أجل أجل أجل أجل أجل أجل أجل أجل أجل أجل أجل أجل + +308 +00:24:08,910 --> 00:24:09,490 +أجل أجل أجل أجل أجل أجل أجل أجل أجل أجل أجل أجل + +309 +00:24:09,490 --> 00:24:09,490 +أجل أجل أجل أجل أجل أجل أجل أجل أجل أجل أجل أجل + +310 +00:24:09,490 --> 00:24:23,070 +أجل أجل أجل أجل أجل أجأنت محق ، لأن الخطأ قريب من + +311 +00:24:23,070 --> 00:24:28,770 +السعر المتوقع ولكن هنا الخطأ كبير + +312 +00:24:28,770 --> 00:24:36,810 +و بعيد من السعر المتوقع، فهذه هي الحالة في السوق ، + +313 +00:24:36,810 --> 00:24:42,110 +فالسعر المتوقع من السعر الحقيقي يعني أننا نحفز + +314 +00:24:42,110 --> 00:24:47,920 +الخطأOkay, now in this course or in this chapter, + +315 +00:24:48,040 --> 00:24:50,820 +we will measure the return, the expected return, + +316 +00:24:51,200 --> 00:24:55,860 +and we will expect this area, the error or the + +317 +00:24:55,860 --> 00:24:57,980 +risk. We consider this is the risk. + +318 +00:25:09,520 --> 00:25:11,820 +How we calculate the expected rate of return? + +319 +00:25:16,280 --> 00:25:21,080 +عادة الـ expected rate of return بسيطة للغاية الـ + +320 +00:25:21,080 --> 00:25:28,980 +expected r هو اقل لصمة الـ probability of I of + +321 +00:25:28,980 --> 00:25:36,060 +times by the ri حسنا، + +322 +00:25:36,060 --> 00:25:42,020 +خذ هذا المثال هنا إذا كان لدينا ثلاث حالات، اثنين، + +323 +00:25:42,020 --> 00:25:50,830 +ثلاثبعض الواقعات المختلفة بي هذه في حالة الـ POOM + +324 +00:25:50,830 --> 00:25:56,310 +هذه في حالة الـ Moderate وهذه في حالة الـ + +325 +00:25:56,310 --> 00:26:06,550 +Recession حسنا، هذه هي الحالة وهذه هي الواقعة في + +326 +00:26:06,550 --> 00:26:13,870 +حالة الـ POOM 30% وفي حالة الـ Moderateلدينا حتى + +327 +00:26:13,870 --> 00:26:23,610 +40% وفي حالة التجارب لدينا 30% لذلك نتوقع في حالة + +328 +00:26:23,610 --> 00:26:32,990 +POM أن عادة السوق R هي 15% في حالة Moderate نتوقع + +329 +00:26:32,990 --> 00:26:37,270 +أن السعر هو 10% في حالة التجارب نتوقع أن السعر + +330 +00:26:37,270 --> 00:26:45,630 +يكون 7%الان نريد ان نخطط ر اذا + +331 +00:26:45,630 --> 00:26:55,970 +اذا اذا + +332 +00:26:55,970 --> 00:27:07,970 +اذا اذا اذا اذا اذا + +333 +00:27:07,970 --> 00:27:12,830 +اذا اذا اذا اذاهذا هو عدد الترجمة المتوقع لـ R + +334 +00:27:12,830 --> 00:27:18,170 +لذلك نسمي هذا عدد الترجمة المتوقع لـ 10 دقيقة + +335 +00:27:18,170 --> 00:27:20,670 +دقيقة دقيقة دقيقة دقيقة دقيقة دقيقة دقيقة دقيقة + +336 +00:27:20,670 --> 00:27:20,750 +دقيقة دقيقة دقيقة دقيقة دقيقة دقيقة دقيقة دقيقة + +337 +00:27:20,750 --> 00:27:22,250 +دقيقة دقيقة دقيقة دقيقة دقيقة دقيقة ديكتر ديكتر + +338 +00:27:22,250 --> 00:27:28,950 +ديكتر ديكتر ديكتر ديكتر ديكتر ديكتر ديكتر + +339 +00:27:28,950 --> 00:27:32,210 +ديكتر + +340 +00:27:36,780 --> 00:27:40,000 +هذا هو قيمة الـ 10 إذا كنا نريد أن نتخيل الـ risk + +341 +00:27:40,000 --> 00:27:41,920 +سنرى كيف نتخيل ال risk + +342 +00:28:02,940 --> 00:28:05,620 +So it is estimated as the average of the possible + +343 +00:28:05,620 --> 00:28:08,380 +returns where each possible return is weighed by + +344 +00:28:08,380 --> 00:28:13,340 +probability that it occurs And this is the example + +345 +00:28:13,340 --> 00:28:19,420 +It looks like our equation was different I like + +346 +00:28:19,420 --> 00:28:23,420 +this just small equationsوهذا expected rate of + +347 +00:28:23,420 --> 00:28:28,520 +return is rate of return R1 times probability of + +348 +00:28:28,520 --> 00:28:33,320 +B1 and then R2 times probability of B2 and Rn + +349 +00:28:33,320 --> 00:28:43,660 +times V0 لذلك نجمع هذا بال R ال R المتوقع هو سم R + +350 +00:28:43,660 --> 00:28:47,540 +I times VI هذا هو + +351 +00:28:53,700 --> 00:29:02,460 +حسنًا الان افعلها لدينا كلمة A لدينا كلمة B لدينا + +352 +00:29:02,460 --> 00:29:09,060 +كلمة .. حسنًا افعل هذا هل يمكنك فعل هذا؟ استخدم ال + +353 +00:29:09,060 --> 00:29:14,740 +.. استخدم ال .. ال .. ال .. ال .. ال .. ال .. ال + +354 +00:29:14,740 --> 00:29:14,900 +.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. + +355 +00:29:14,900 --> 00:29:15,340 +ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال + +356 +00:29:15,340 --> 00:29:16,340 +.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. + +357 +00:29:16,340 --> 00:29:17,420 +ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال + +358 +00:29:17,420 --> 00:29:17,480 +.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. + +359 +00:29:17,480 --> 00:29:17,760 +ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال + +360 +00:29:17,760 --> 00:29:17,800 +.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. + +361 +00:29:17,800 --> 00:29:17,800 +ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال + +362 +00:29:17,800 --> 00:29:21,760 +.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. + +363 +00:29:22,460 --> 00:29:29,460 +يجب أن يكون 100% الآن كلمة C في 20% يمكننا أن نحصل + +364 +00:29:29,460 --> 00:29:35,240 +على 9000$ نهاية السعر السابق هذا هو السعر البداية + +365 +00:29:35,240 --> 00:29:41,360 +حسنا و حاول أن تفعل هذا + +366 +00:29:47,820 --> 00:29:51,880 +احاول ان تفعل هذا سأرى كيف يمكنك فعل هذا لديك + +367 +00:29:51,880 --> 00:29:55,500 +الإجابة في النهاية ولكن اريد ان اتفق إذا كنت + +368 +00:29:55,500 --> 00:30:03,000 +مفهومة او ليس مفهومة فقط فعلها نعم نعم هذا الجمهور + +369 +00:30:03,000 --> 00:30:08,060 +فعلا فعلا فعلا فعلا فعلا فعلا فعلا فعلا فعلا فعلا + +370 +00:30:08,060 --> 00:30:10,240 +فعلا فعلا فعلا + +371 +00:30:20,950 --> 00:30:30,270 +وفي النهاية سوف نجمع الفيجورين مرة + +372 +00:30:30,270 --> 00:30:40,990 +أخرى كلمة B هي probability بي بي بي بي بي بي بي بي + +373 +00:30:40,990 --> 00:30:44,210 +بي + +374 +00:30:44,210 --> 00:30:45,590 +بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي + +375 +00:30:45,590 --> 00:30:49,970 +بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي + +376 +00:30:49,970 --> 00:30:49,970 +بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي + +377 +00:30:49,970 --> 00:30:49,970 +بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي + +378 +00:30:49,970 --> 00:30:49,970 +بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي بي + +379 +00:30:49,970 --> 00:30:56,370 +بي بي بي بي برغم هذا، كيف تتخيل عادة العودة؟ مثل + +380 +00:30:56,370 --> 00:31:00,550 +هذا، ولكننا لا نحصل على الحصول على الحصول على + +381 +00:31:00,550 --> 00:31:00,550 +الحصول على الحصول على الحصول على الحصول على الحصول + +382 +00:31:00,550 --> 00:31:01,690 +على الحصول على الحصول على الحصول على الحصول على + +383 +00:31:01,690 --> 00:31:03,290 +الحصول على الحصول على الحصول على الحصول على الحصول + +384 +00:31:03,290 --> 00:31:03,830 +على الحصول على الحصول على الحصول على الحصول على + +385 +00:31:03,830 --> 00:31:05,450 +الحصول على الحصول على الحصول على الحصول على الحصول + +386 +00:31:05,450 --> 00:31:05,530 +على الحصول على الحصول على الحصول على الحصول على + +387 +00:31:05,530 --> 00:31:05,530 +الحصول على الحصول على الحصول على الحصول على الحصول + +388 +00:31:05,530 --> 00:31:05,530 +على الحصول على الحصول على الحصول على الحصول على + +389 +00:31:05,530 --> 00:31:05,530 +الحصول على الحصول على الحصول على الحصول على الحصول + +390 +00:31:05,530 --> 00:31:09,310 +على الحصول على الحصول على الحصول على الحصول على + +391 +00:31:09,310 --> 00:31:17,090 +الحصول على الحص + +392 +00:31:19,160 --> 00:31:27,420 +القسم الأول، هل أنت محق؟ في حالة التجارب، ما هو .. + +393 +00:31:27,420 --> 00:31:33,620 +هذا هو ما يتوقع في حالة التجارب، الـR المتوقع في + +394 +00:31:33,620 --> 00:31:43,420 +حالة التجارب، و القسم الثاني، 3.6%، والنسبة + +395 +00:31:43,420 --> 00:31:53,410 +الثالثة،11% لذلك في النهاية فقط تجمع هذا لديك 12.6 + +396 +00:31:53,410 --> 00:31:58,070 +% هو عدد الترجمة المتوقع عدد الترجمة المتوقع عدد + +397 +00:31:58,070 --> 00:31:58,630 +الترجمة المتوقع عدد الترجمة المتوقع عدد الترجمة + +398 +00:31:58,630 --> 00:32:01,750 +المتوقع عدد الترجمة المتوقع عدد الترجمة المتوقع + +399 +00:32:01,750 --> 00:32:02,730 +عدد الترجمة المتوقع عدد الترجمة المتوقع عدد + +400 +00:32:02,730 --> 00:32:02,730 +الترجمة المتوقع عدد الترجمة المتوقع عدد الترجمة + +401 +00:32:02,730 --> 00:32:02,730 +المتوقع عدد الترجمة المتوقع عدد الترجمة المتوقع + +402 +00:32:02,730 --> 00:32:03,470 +عدد الترجمة المتوقع عدد الترجمة المتوقع عدد + +403 +00:32:03,470 --> 00:32:09,270 +الترجمة المتوقع عدد الترجمة المتوقع عدد الترجمة + +404 +00:32:09,270 --> 00:32:12,570 +المتوقع عدد + +405 +00:32:12,570 --> 00:32:21,480 +الترجمة المتوقعماذا بالضبط يعني ان تنظر إلى هذا + +406 +00:32:21,480 --> 00:32:25,060 +الشارت انه + +407 +00:32:25,060 --> 00:32:32,300 +بالضبط يعني هذا لدينا هذه الملاحظة في حالة .. في + +408 +00:32:32,300 --> 00:32:35,980 +حالة growth في حالة recession لدينا الملاحظة هنا + +409 +00:32:35,980 --> 00:32:45,240 +وفي حالة moderate مثلا هنا وفي حالة growth لدينا + +410 +00:32:45,240 --> 00:32:52,790 +الملاحظة هنايبدو هكذا فالعامة + +411 +00:32:52,790 --> 00:33:00,410 +او الاتجاه المتوقع هو دعنا نرى هي حوالي هنا + +412 +00:33:00,410 --> 00:33:03,770 +الاتجاه + +413 +00:33:03,770 --> 00:33:08,110 +المتوقع هذا هو المنطقة المتوقعة الآن ماهي الخطأ + +414 +00:33:08,110 --> 00:33:14,390 +إذا كنا نريد أن نخطط الخطأ فهذه المنطقة 12.6% هذا + +415 +00:33:14,390 --> 00:33:24,360 +هو الاتجاه المتوقعالان ماهي الخطأ في تخطيط الـAR؟ + +416 +00:33:24,360 --> 00:33:31,840 +فالخطأ هو هذا، على سبيل المثال الـrecession، minus + +417 +00:33:31,840 --> 00:33:37,780 +هذا، هذا هو الخطأ، و هذا minus هذا و هذا minus هذا + +418 +00:33:38,500 --> 00:33:44,320 +difference between the expected rate of return and + +419 +00:33:44,320 --> 00:33:52,620 +the probability of the cases here okay this is by + +420 +00:33:52,620 --> 00:33:59,080 +using the chart let's see by using the variance or + +421 +00:33:59,080 --> 00:34:04,360 +the standard deviation or by using sigma sigma of + +422 +00:34:04,360 --> 00:34:27,100 +RRi-RiRiRiRiRiRiRi + +423 +00:34:36,940 --> 00:34:45,080 +Okay, how we calculate this؟ So this + +424 +00:34:45,080 --> 00:34:50,500 +is 12.6% Measuring risk Standard deviation is + +425 +00:34:50,500 --> 00:34:53,140 +given by square root of the variance and is more + +426 +00:34:53,140 --> 00:34:56,940 +commonly used It's more commonly used, but it is + +427 +00:34:56,940 --> 00:35:03,640 +not the accurate It has some consensus Sorry؟ + +428 +00:35:10,870 --> 00:35:15,450 +خلّيني أقارنها بإستخدامات ممكنة للإستخدام، لدينا + +429 +00:35:15,450 --> 00:35:18,130 +بيانات محافظة الولايات المتحدة، وكما تعرفين بيانات + +430 +00:35:18,130 --> 00:35:22,550 +محافظة الولايات المتحدة هي أقل أسرع و أقل أسرع و + +431 +00:35:22,550 --> 00:35:25,570 +أقل أسرع و أقل أسرع و أقل أسرع و أقل أسرع و أقل + +432 +00:35:25,570 --> 00:35:25,890 +أسرع و أقل أسرع و أقل أسرع و أقل أسرع و أقل أسرع و + +433 +00:35:25,890 --> 00:35:27,310 +أقل أسرع و أقل أسرع و أقل أسرع و أقل أسرع و أقل + +434 +00:35:27,310 --> 00:35:30,390 +أسرع و أقل أسرع و أقل أسرع و أقل أسرع و + +435 +00:35:36,050 --> 00:35:38,230 +حسنًا، فإن مجموعة المفروضات التي تحتوي على إستخدام + +436 +00:35:38,230 --> 00:35:41,770 +المستخدام تحتوي على كل المستخدامات الممكنة منها مع + +437 +00:35:41,770 --> 00:35:46,730 +المفروضات المرتبطة بها دعونا نلقي نظرة على الـ7 + +438 +00:35:46,730 --> 00:35:52,750 +هذه اللي هي اللي بلو، هذه اللي هي اللي هي اللي هي + +439 +00:35:52,750 --> 00:35:53,330 +اللي هي اللي هي اللي هي اللي هي اللي هي اللي هي + +440 +00:35:53,330 --> 00:35:53,630 +اللي هي اللي هي اللي هي اللي هي اللي هي اللي هي + +441 +00:35:53,630 --> 00:35:55,350 +اللي هي اللي هي اللي هي اللي هي اللي هي اللي هي + +442 +00:35:55,350 --> 00:35:55,950 +اللي هي اللي هي اللي هي اللي هي اللي هي اللي هي + +443 +00:35:55,950 --> 00:35:55,970 +اللي هي اللي هي اللي هي اللي هي اللي هي اللي هي + +444 +00:35:55,970 --> 00:35:55,970 +اللي هي اللي هي اللي هي اللي هي اللي هي اللي هي + +445 +00:35:55,970 --> 00:36:02,970 +اللي هي اللي هي اللي هي اللي هي اللي هي اللي + +446 +00:36:02,970 --> 00:36:08,940 +هي اللهو مستقل هنا و لا يوجد فلكتوات فقط إذا كنت + +447 +00:36:08,940 --> 00:36:13,960 +تنظر إلى هذا هنا لا يوجد فلكتوات فعلا فإن مستقل أو + +448 +00:36:13,960 --> 00:36:21,600 +سيجما يقل إلى نصف إذا كنا نلاحظ مثل هذا لا تغيير + +449 +00:36:21,600 --> 00:36:28,820 +فما هو الخطأ؟أو إذا كنت تشاهد مثلًا الـ Linear، + +450 +00:36:28,820 --> 00:36:32,160 +فلا يوجد خطأ هنا ولكن إذا كنت تشاهد مثلًا هذا، + +451 +00:36:32,160 --> 00:36:39,520 +فهناك خطأ فقط لكي ترى ماذا يعني الخطأ ولكن انظر + +452 +00:36:39,520 --> 00:36:47,800 +إلى الأسعار، الأسعار مفتوحة من 10 + +453 +00:36:47,800 --> 00:36:57,080 +% إلى 5% إلى 15% إلى 25% إلى 40%Okay, so this is + +454 +00:36:57,080 --> 00:37:02,240 +the possible returns. But in the case of treasury + +455 +00:37:02,240 --> 00:37:04,800 +bills, this is the small one, the majority are + +456 +00:37:04,800 --> 00:37:10,200 +five percent or most of them five percent. So we + +457 +00:37:10,200 --> 00:37:14,320 +summarize in this case that + +458 +00:37:16,200 --> 00:37:22,640 +السوق يحافظ على إعادة أعلى من عمليات المحافظة وفي + +459 +00:37:22,640 --> 00:37:27,080 +الوقت نفسه يحافظ على أعلى حرارة إذا كنت تنظر، هذا + +460 +00:37:27,080 --> 00:37:34,900 +هو البيانات للسوق إذا كنت تنظر إلى بيانات السوقهو + +461 +00:37:34,900 --> 00:37:42,160 +نقل من 10% لـ 5% و 15% و 25% فهو مفتوح بالنسبة + +462 +00:37:42,160 --> 00:37:50,940 +للأسعار الخاصة 5% و 5% فلا تتغير اي شيء فالخطر أو + +463 +00:37:50,940 --> 00:37:53,160 +الانتجار العام هو نقل + +464 +00:38:07,000 --> 00:38:13,800 +كيف نقوم بتخطيط ال .. كيف نقوم بتخطيط ال .. كيف + +465 +00:38:13,800 --> 00:38:13,800 +نقوم بتخطيط ال .. كيف نقوم بتخطيط ال .. كيف نقوم + +466 +00:38:13,800 --> 00:38:13,800 +بتخطيط ال .. كيف نقوم بتخطيط ال .. كيف نقوم بتخطيط + +467 +00:38:13,800 --> 00:38:13,840 +ال .. كيف نقوم بتخطيط ال .. كيف نقوم بتخطيط ال .. + +468 +00:38:13,840 --> 00:38:14,160 +كيف نقوم بتخطيط ال .. كيف نقوم بتخطيط ال .. كيف + +469 +00:38:14,160 --> 00:38:14,160 +نقوم بتخطيط ال .. كيف نقوم بتخطيط ال .. كيف نقوم + +470 +00:38:14,160 --> 00:38:14,560 +بتخطيط ال .. كيف نقوم بتخطيط ال .. كيف نقوم بتخطيط + +471 +00:38:14,560 --> 00:38:15,480 +ال .. كيف نقوم بتخطيط ال .. كيف نقوم بتخطيط ال .. + +472 +00:38:15,480 --> 00:38:34,720 +كيف + +473 +00:38:34,720 --> 00:38:40,090 +نقوم بتخطSo enjoy in the exam Yes السلام عليكم + diff --git a/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/EHr5CKkd8R4_postprocess.srt b/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/EHr5CKkd8R4_postprocess.srt new file mode 100644 index 0000000000000000000000000000000000000000..fa6df37877038ec81a5766d4090dede2982acfae --- /dev/null +++ b/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/EHr5CKkd8R4_postprocess.srt @@ -0,0 +1,1564 @@ +1 +00:00:20,690 --> 00:00:23,570 +بسم الله الرحمن الرحيم، in the previous meetings + +2 +00:00:23,570 --> 00:00:27,550 +we talked about the average rate of return and the + +3 +00:00:27,550 --> 00:00:34,210 +measure of riskنقوم بتقيم عدد العودة باستخدام عدد + +4 +00:00:34,210 --> 00:00:36,610 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +5 +00:00:36,610 --> 00:00:36,870 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +6 +00:00:36,870 --> 00:00:38,770 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +7 +00:00:38,770 --> 00:00:39,670 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +8 +00:00:39,670 --> 00:00:43,270 +عدد عدد عدد عدد عدد عدد + +9 +00:00:43,270 --> 00:00:56,590 +عدد عد + +10 +00:00:56,990 --> 00:01:03,510 +and to give more light on the geometric we will + +11 +00:01:03,510 --> 00:01:06,450 +compare between the geometric and arithmetic + +12 +00:01:06,450 --> 00:01:11,870 +average rate of return the first question is what + +13 +00:01:11,870 --> 00:01:15,350 +is the difference between geometric and arithmetic + +14 +00:01:15,350 --> 00:01:20,550 +okay what is geometric and what is the arithmetic + +15 +00:01:22,640 --> 00:01:25,360 +Okay, arithmetic average may not always capture + +16 +00:01:25,360 --> 00:01:29,000 +the true rate of return on an investment in some + +17 +00:01:29,000 --> 00:01:33,240 +cases geometric or compounded be more appropriate + +18 +00:01:33,240 --> 00:01:38,300 +measure of return because the arithmetic has some + +19 +00:01:38,300 --> 00:01:44,280 +weaknesses in estimating the rate of return so we + +20 +00:01:44,280 --> 00:01:48,060 +apply the geometric to address the weaknesses of + +21 +00:01:48,060 --> 00:01:53,030 +the arithmetic or the arithmetic rate of returnعلى + +22 +00:01:53,030 --> 00:01:57,970 +سبيل المثال، تخيل أنك أشتريت أسعار لـ 25$ تخيل أنك + +23 +00:01:57,970 --> 00:01:58,970 +أشتريت أسعار لـ 25$ تخيل أنك أشتريت أسعار لـ 25$ + +24 +00:01:58,970 --> 00:01:59,570 +تخيل أنك أشتريت أسعار لـ 25$ تخيل أنك أشتريت أسعار + +25 +00:01:59,570 --> 00:02:02,830 +لـ 25$ تخيل أنك أشتريت أسعار لـ 25$ تخيل أنك + +26 +00:02:02,830 --> 00:02:04,510 +أشتريت أسعار لـ 25$ تخيل أنك أشتريت أسعار لـ 25$ + +27 +00:02:04,510 --> 00:02:05,270 +تخيل أنك أشتريت أسعار لـ 25$ تخيل أنك أشتريت أسعار + +28 +00:02:05,270 --> 00:02:08,890 +لـ 25$ تخيل أنك أشتريت أسعار لـ 25$ تخيل أنك + +29 +00:02:08,890 --> 00:02:19,570 +أشتريت أسعار لـ 25 + +30 +00:02:21,770 --> 00:02:23,750 +What is the average rate of these investments? + +31 +00:02:24,830 --> 00:02:27,930 +This is very very simple what we can do it started + +32 +00:02:27,930 --> 00:02:38,530 +30 then 25 then 15 okay so 30 25 and 15 + +33 +00:02:42,040 --> 00:02:50,020 +العادة تستخدم تقسيم المقاطع السابقة تقسيمها P1-P0 + +34 +00:02:50,020 --> 00:02:59,320 +Divided by P0 ب 25 ثم + +35 +00:02:59,320 --> 00:03:08,560 +30 ثم 30 ثم 15so in this here thirty minus twenty + +36 +00:03:08,560 --> 00:03:13,740 +five divided by twenty five then fifteen minus + +37 +00:03:13,740 --> 00:03:21,780 +thirty divided by thirty twenty percent and this + +38 +00:03:21,780 --> 00:03:26,620 +the second minus fifty percent so the average is + +39 +00:03:26,620 --> 00:03:29,880 +twenty + +40 +00:03:29,880 --> 00:03:44,640 +percent plus minus fifty percentمع 2 20-50-30-15% + +41 +00:03:44,640 --> 00:03:50,700 +هل هذا صحيح؟ فهذا + +42 +00:03:50,700 --> 00:03:57,340 +هو عدد عدد العودة هذا عدد عدد عدد العودة يعتمد على + +43 +00:03:57,340 --> 00:04:07,430 +الأساسيات الارثمالية كيف نخطط هذا 30-25ثم 15-30 + +44 +00:04:07,430 --> 00:04:15,670 +نحن نخبره عن هذا وانت + +45 +00:04:15,670 --> 00:04:21,250 +ترى هذا النتائج 15% ولكن إذا كنا نخبره بطريقات + +46 +00:04:21,250 --> 00:04:27,050 +مختلفة، تعتبر هذه الحالة ما فعلناه أو كيف نخبره عن + +47 +00:04:27,050 --> 00:04:33,910 +الارثماتيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيك + +48 +00:04:35,280 --> 00:04:41,600 +أو عادة عادة عادة + +49 +00:04:41,600 --> 00:04:45,040 +عادة عادة عادة عادة عادة عادة عادة عادة عادة عادة + +50 +00:04:45,040 --> 00:04:48,000 +عادة عادة عادة عادة عادة عادة عادة عادة عادة عادة + +51 +00:04:48,000 --> 00:04:48,080 +عادة عادة عادة عادة عادة عادة عادة عادة عادة عادة + +52 +00:04:48,080 --> 00:04:50,500 +عادة عادة عادة عادة عادة عادة عادة عادة عادة عادة + +53 +00:04:50,500 --> 00:04:51,260 +عادة عادة عادة عادة عادة عادة عادة عادة عادة عادة + +54 +00:04:51,260 --> 00:04:51,760 +عادة عادة عادة عادة عادة عادة عادة عادة عادة عادة + +55 +00:04:51,760 --> 00:04:54,260 +عادة عادة عادة عادة عادة عادة عادة عادة عادة عادة + +56 +00:04:54,260 --> 00:04:55,060 +عادة + +57 +00:05:02,160 --> 00:05:08,260 +ولذلك نعتبر أن هذا هو الانتقال وهذا هو النهاية في + +58 +00:05:08,260 --> 00:05:15,740 +هذه الحالة .. في هذه الحالة، السعر يتحرك من 25 + +59 +00:05:15,740 --> 00:05:24,040 +دولار إلى 15 دولار، لذلك يتخيل الثقافة، الثقافة أو + +60 +00:05:24,040 --> 00:05:33,200 +نرى ثقافة الترجمة إذا كنا نعتبر هذا اكس و Y اكسهذه + +61 +00:05:33,200 --> 00:05:40,240 +اكسس X وهذه اكسس Y في عادة الترجمه السعر يتحرك من + +62 +00:05:40,240 --> 00:05:44,880 +25 إلى 30 ثم 30 إلى 15 لكن في الجيومتريك + +63 +00:05:44,880 --> 00:05:51,860 +الجيومتريك يعتبر تحرك كل هذا من 25 إلى 15 في كلمات + +64 +00:05:51,860 --> 00:05:59,320 +أخرى الجيومتريك يعتبر عدد الترجمه أو عدد الترجمه + +65 +00:06:04,460 --> 00:06:09,100 +the arithmetic again is based on the simple + +66 +00:06:09,100 --> 00:06:15,040 +average rate of return based on the simple average + +67 +00:06:15,040 --> 00:06:18,540 +rate of return however the geometric is based on + +68 +00:06:18,540 --> 00:06:24,040 +the compounded rate of return okay the compounded + +69 +00:06:31,510 --> 00:06:36,270 +الاريثماتيك يتخيل بسبب عمره يولي أو يومي أو بسبب + +70 +00:06:36,270 --> 00:06:38,910 +عمره يولي أو يومي أو بسبب عمره يولي أو يومي أو + +71 +00:06:38,910 --> 00:06:39,890 +بسبب عمره يولي أو بسبب عمره يولي أو بسبب عمره يولي + +72 +00:06:39,890 --> 00:06:42,370 +أو بسبب عمره يولي أو بسبب عمره يولي أو بسبب عمره + +73 +00:06:42,370 --> 00:06:42,830 +يولي أو بسبب عمره يولي أو بسبب عمره يولي أو بسبب + +74 +00:06:42,830 --> 00:06:43,310 +عمره يولي أو بسبب عمره يولي أو بسبب عمره يولي أو + +75 +00:06:43,310 --> 00:06:50,390 +أو بسبب عمره يولي أو بسبب عمره يولي أو بسبب عمره + +76 +00:06:50,390 --> 00:06:58,910 +يولي أو + +77 +00:07:03,710 --> 00:07:11,490 +geometric is equal to the roots, the n roots of + +78 +00:07:11,490 --> 00:07:18,550 +the summation of one plus or the multiplied of one + +79 +00:07:18,550 --> 00:07:26,490 +plus r minus one and consider this is one, ri + +80 +00:07:29,240 --> 00:07:35,420 +لنعود إلى المثال السابق في المثال السابق بدأنا بـ + +81 +00:07:35,420 --> 00:07:45,340 +25 ثم 30 ثم تنزل إلى 15 دولار و كما تخططنا عادية + +82 +00:07:45,340 --> 00:07:53,970 +30, 25 و15 هي عادية .. كم عادية هذا؟لأ، لأ، هذا + +83 +00:07:53,970 --> 00:08:04,430 +الـ 20% 20% وهو مناسب 50% فكيف نتخيله ببساطة هذه + +84 +00:08:04,430 --> 00:08:19,190 +المثالة هي هكذا 1 plus 0.20 times 1 minus 50 + +85 +00:08:21,620 --> 00:08:30,660 +أو 0.15 okay and raised to the power one divided + +86 +00:08:30,660 --> 00:08:37,420 +by two minus one so + +87 +00:08:37,420 --> 00:08:44,540 +what is the result negative 22.5 22.5 22.5 are you + +88 +00:08:44,540 --> 00:08:48,760 +sure negative are you sure + +89 +00:08:51,920 --> 00:08:55,860 +ماذا تقول؟ يجب أن تكون تحقق مرتفع مرتفع مرتفع + +90 +00:08:55,860 --> 00:09:01,000 +مرتفع مرتفع مرتفع مرتفع + +91 +00:09:01,000 --> 00:09:11,980 +مرتفع مرتفع مرتفع مرتفع + +92 +00:09:11,980 --> 00:09:15,240 +مرتفع مرتفع + +93 +00:09:18,630 --> 00:09:26,750 +ولكن هذا هو سلوب أو هذا هو عدد التجارب التي تتحرك + +94 +00:09:26,750 --> 00:09:33,050 +من 25 إلى 15 دولار لذلك سنعتبر هذا .. لأنها تتحرك + +95 +00:09:33,050 --> 00:09:40,880 +خلال فترة من الوقت ، إنها تتجارب من 25 إلى 15هذا + +96 +00:09:40,880 --> 00:09:44,700 +لا يعني ان هذا في واحد قطع من 25 إلى 15 ، فهذا + +97 +00:09:44,700 --> 00:09:48,380 +يتجول في مدينة ومدينة، يتجول في السنوات، يتجول في + +98 +00:09:48,380 --> 00:09:55,360 +الأيام، فالفكرة هي الـ Geometric هي المزيد من + +99 +00:09:55,360 --> 00:10:01,240 +العودة في طريق المحركات + +100 +00:10:04,870 --> 00:10:09,910 +فهي في الاريثماتيك الـ-15% هي عملة الاريثماتيك + +101 +00:10:09,910 --> 00:10:15,890 +البسيطة بينما الـ-22% هي عملة الاريثماتيك البسيطة + +102 +00:10:15,890 --> 00:10:20,690 +المجموعة؟ نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، + +103 +00:10:20,690 --> 00:10:21,390 +نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، + +104 +00:10:21,390 --> 00:10:21,790 +نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، + +105 +00:10:21,790 --> 00:10:23,270 +نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، نعم، + +106 +00:10:23,270 --> 00:10:28,150 +نعم، نعم، نعم، نعم، + +107 +00:10:28,150 --> 00:10:31,390 +نعم، + +108 +00:10:31,390 --> 00:10:36,970 +نbecause geometric reflect the risk, the risk of + +109 +00:10:36,970 --> 00:10:40,770 +the business others + +110 +00:10:40,770 --> 00:10:45,210 +prefer the average or arithmetic because + +111 +00:10:45,210 --> 00:10:51,870 +arithmetic reflect the periods of returnإذا قمت + +112 +00:10:51,870 --> 00:10:54,870 +بالتخطيط يعتمد على عودة عامة، فهو بخير لتطبيق + +113 +00:10:54,870 --> 00:11:03,290 +الارثماتيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكي + +114 +00:11:10,430 --> 00:11:13,090 +لذلك مرة أخرى، عدد المستوى الجيوميطيكي للعودة يجيب + +115 +00:11:13,090 --> 00:11:17,270 +على السؤال ما كان عدد الثقافة لعبادتك، ففي هذه + +116 +00:11:17,270 --> 00:11:23,670 +الحالة عدد الثقافة هو 22% ولكن إذا كنا نتكلم عن + +117 +00:11:23,670 --> 00:11:27,930 +الارثماتيك، فإن الارثماتيك ليس مفهوم عن عدد + +118 +00:11:27,930 --> 00:11:33,690 +الثقافة للعودة، فإن الارثماتيك مفهوم عن مصممة + +119 +00:11:33,690 --> 00:11:38,100 +السنواتI'm not considering the whole periods of + +120 +00:11:38,100 --> 00:11:41,820 +the investments. The arithmetic average rate of + +121 +00:11:41,820 --> 00:11:44,200 +return answer the question what was the average of + +122 +00:11:44,200 --> 00:11:47,160 +the yearly rate of return, yearly or daily rate of + +123 +00:11:47,160 --> 00:11:49,580 +return or quarterly rate of return. I'm not + +124 +00:11:49,580 --> 00:11:54,380 +considering the whole investments or the whole + +125 +00:11:54,380 --> 00:11:56,820 +performance of the investmentsعن طريق هذا + +126 +00:11:56,820 --> 00:12:01,820 +الجيومتريك هو 1 plus rate of return times rate of + +127 +00:12:01,820 --> 00:12:06,760 +return of the second year and till year n raised + +128 +00:12:06,760 --> 00:12:10,100 +to the power of 1 divided by n وهو ما يمكننا أن + +129 +00:12:10,100 --> 00:12:17,580 +نضعه تحت القواعد minus 1 عملت + +130 +00:12:17,580 --> 00:12:19,100 +جيومتريك rate of return + +131 +00:12:24,250 --> 00:12:29,950 +We don't need this 25 okay + +132 +00:12:29,950 --> 00:12:34,050 +so if we have this this this stock this is + +133 +00:12:34,050 --> 00:12:40,210 +different one and we start the business by 25$ we + +134 +00:12:40,210 --> 00:12:45,440 +can do it again this oneبدأنا بـ 25 دولار ثم في + +135 +00:12:45,440 --> 00:12:50,380 +السنة الأولى .. لذلك مستقبلنا 25 دولار مستقبلنا + +136 +00:12:50,380 --> 00:12:53,640 +مستقبلنا عندما قلت مستقبلنا مستقبلنا تعتبر هذه + +137 +00:12:53,640 --> 00:12:58,240 +السطحانة تبدأ بـ 0, 1, 2 مستقبلنا مستقبلنا يبدأ بـ + +138 +00:12:58,240 --> 00:13:03,880 +25 دولار ثم في نهاية العام 35 دولار ثم في نهاية + +139 +00:13:03,880 --> 00:13:09,620 +العام الثانوية 17.5 دولار لذلك باستخدام الشارتفي + +140 +00:13:09,620 --> 00:13:15,880 +هذا الشارت ، لذلك في إزارة هنا بدأت بـ 25 ، هذا 5 + +141 +00:13:15,880 --> 00:13:25,840 +، هذا 10 ، 20, 25 ، لذلك كانت هنا ، حسنًا 25 ثم + +142 +00:13:25,840 --> 00:13:32,200 +تتحرك إلى .. في السنة الثانوية تتحرك إلى 35 ، هذا + +143 +00:13:32,200 --> 00:13:39,110 +35ثم في السنة الثانية، تتحرك إلى 17.5، لذا دعنا + +144 +00:13:39,110 --> 00:13:45,810 +نذهب، دعنا نذهب هنا، حسنًا؟ لذلك، عمليات الثقافة + +145 +00:13:45,810 --> 00:13:52,760 +على مقارنة الجيومتريكي هي أقلhow it was here 25 + +146 +00:13:52,760 --> 00:13:57,920 +and then 35 and here is 17.5 if we want to + +147 +00:13:57,920 --> 00:14:00,940 +calculate the average rate of return for the + +148 +00:14:00,940 --> 00:14:08,940 +arithmetic just do this 25 35 and 17.5 do like + +149 +00:14:08,940 --> 00:14:14,980 +this 35 minus 25 divided by 25 and then 17.5 minus + +150 +00:14:14,980 --> 00:14:18,140 +35 divided by 17.5 + +151 +00:14:21,620 --> 00:14:25,620 +Okay so this is forty percent and this is minus + +152 +00:14:25,620 --> 00:14:30,820 +fifty percent then forty percent minus fifty + +153 +00:14:30,820 --> 00:14:37,640 +percent divided by two we have minus five percent + +154 +00:14:37,640 --> 00:14:44,150 +this is based on the arithmeticبسيطة على + +155 +00:14:44,150 --> 00:15:04,970 +الارثماتيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكي + +156 +00:15:10,910 --> 00:15:17,650 +yes 23 so it moved to this year 23 okay is it is + +157 +00:15:17,650 --> 00:15:23,170 +it right according to the average the price + +158 +00:15:23,170 --> 00:15:29,640 +dropped to the 23 but this is not rightتتقل إلى 17 + +159 +00:15:29,640 --> 00:15:36,760 +.5، هذا هو السبب ان الاريثماتيك لا يتفكر باستخدام + +160 +00:15:36,760 --> 00:15:45,360 +في الوقت كله، فهو فقط عدد الوقت، لكن اعود للتعامل + +161 +00:15:45,360 --> 00:15:52,910 +بالجيومتريك، الجيومتريك 40%just do it in this way + +162 +00:15:52,910 --> 00:16:00,330 +one point forty times point fifty okay raised to + +163 +00:16:00,330 --> 00:16:04,370 +the power one divided by two minus one negative + +164 +00:16:04,370 --> 00:16:08,290 +sixteen + +165 +00:16:08,290 --> 00:16:15,500 +point forty مش خمسين مش حاجيتها واحد point خمسةما + +166 +00:16:15,500 --> 00:16:20,640 +واحد one plus minus fifty one plus minus fifty + +167 +00:16:20,640 --> 00:16:27,060 +percent this is minus okay + +168 +00:16:27,060 --> 00:16:33,180 +so + +169 +00:16:33,180 --> 00:16:39,460 +minus fifty percent is minus one and you will see + +170 +00:16:41,620 --> 00:16:48,720 +طبعا تحاول ان ترى 25 + +171 +00:16:48,720 --> 00:16:52,940 +$ x 1-60.33 + +172 +00:17:16,390 --> 00:17:26,350 +على أية حال، انظر + +173 +00:17:26,350 --> 00:17:31,670 +إلى الجانب الأسفل الخارجي، هل مجرد عدد عدد عدد عدد + +174 +00:17:31,670 --> 00:17:31,910 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +175 +00:17:31,910 --> 00:17:33,790 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +176 +00:17:33,790 --> 00:17:33,890 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +177 +00:17:33,890 --> 00:17:35,490 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +178 +00:17:35,490 --> 00:17:41,050 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +179 +00:17:41,050 --> 00:17:45,520 +عددلذلك في هذه الحالة هنا إذا كنت تتوقع انتقال + +180 +00:17:45,520 --> 00:17:51,080 +السنة المقبلة تستخدم الارثماتيك لكن إذا كنت تتوقع + +181 +00:17:51,080 --> 00:17:53,880 +انتقال السنة المقبلة عامة عامة عامة عامة عامة عامة + +182 +00:17:53,880 --> 00:17:56,520 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +183 +00:17:56,520 --> 00:17:58,380 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +184 +00:17:58,380 --> 00:17:58,700 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +185 +00:17:58,700 --> 00:18:04,120 +عامة عامة عامة عامة عامة عامة عامة عامة عامة + +186 +00:18:08,370 --> 00:18:13,890 +خمس سنة قبل ماري أختي أعطاه 10 ألف دولار من + +187 +00:18:13,890 --> 00:18:17,810 +المحافظة بالمحافظة بالمحافظة بالمحافظة بالمحافظة + +188 +00:18:17,810 --> 00:18:19,490 +بالمحافظة بالمحافظة بالمحافظة بالمحافظة بالمحافظة + +189 +00:18:19,490 --> 00:18:22,210 +بالمحافظة بالمحافظة بالمحافظة بالمحافظة بالمحافظة + +190 +00:18:22,210 --> 00:18:22,230 +بالمحافظة بالمحافظة بالمحافظة بالمحافظة بالمحافظة + +191 +00:18:22,230 --> 00:18:22,930 +بالمحافظة بالمحافظة بالمحافظة بالمحافظة بالمحافظة + +192 +00:18:22,930 --> 00:18:28,190 +بالمحافظة بالمحافظة + +193 +00:18:28,190 --> 00:18:33,670 +بالمحافظة + +194 +00:18:33,670 --> 00:18:36,270 +بالم + +195 +00:18:36,920 --> 00:18:42,900 +فهي ترغب في التعامل لتقرر اذا كانت تعمل جيدا او لا + +196 +00:18:42,900 --> 00:18:46,240 +تعمل جيدا او + +197 +00:18:46,240 --> 00:18:46,260 +لا تعمل جيدا او لا تعمل جيدا او لا تعمل جيدا او لا + +198 +00:18:46,260 --> 00:18:46,440 +تعمل جيدا او لا تعمل جيدا او لا تعمل جيدا او لا + +199 +00:18:46,440 --> 00:18:46,580 +تعمل جيدا او لا تعمل جيدا او لا تعمل جيدا او لا + +200 +00:18:46,580 --> 00:18:47,020 +تعمل جيدا او لا تعمل جيدا او لا تعمل جيدا او لا + +201 +00:18:47,020 --> 00:18:49,100 +تعمل جيدا او لا تعمل جيدا او لا تعمل جيدا او لا + +202 +00:18:49,100 --> 00:19:01,580 +تعمل جيدا او لا تعمل جيدا او + +203 +00:19:01,580 --> 00:19:05,180 +لا تعمل جيد + +204 +00:19:07,600 --> 00:19:10,840 +if you are interested in excel why I'm applying + +205 +00:19:10,840 --> 00:19:14,800 +excel because in your assignments I think it's + +206 +00:19:14,800 --> 00:19:24,120 +important to apply excel I think yes you try so + +207 +00:19:24,120 --> 00:19:32,480 +this is here and zero one two + +208 +00:19:36,910 --> 00:19:44,290 +أنا لا أحب أن أسمع هذا لماذا؟ لأنك يجب أن تعرف لدي + +209 +00:19:44,290 --> 00:19:49,090 +وقت فارغ فارغ فارغ فارغ فارغ فارغ فارغ فارغ فارغ + +210 +00:19:49,090 --> 00:19:50,050 +فارغ فارغ فارغ فارغ فارغ فارغ فارغ فارغ فارغ فارغ + +211 +00:19:50,050 --> 00:19:51,550 +فارغ فارغ فارغ فارغ فارغ فارغ فارغ فارغ فارغ فارغ + +212 +00:19:51,550 --> 00:19:54,910 +فارغ فارغ فارغ فارغ فارغ فارغ فارغ فارغ فارغ فارغ + +213 +00:19:54,910 --> 00:19:54,970 +فارغ فارغ فارغ فارغ فارغ فارغ + +214 +00:20:16,970 --> 00:20:20,190 +and in the second year eleven thousand + +215 +00:20:25,440 --> 00:20:31,500 +أنا ماكنتش خلتش .. ده بتاعتها واسمها كمان .. كمان + +216 +00:20:31,500 --> 00:20:38,020 +.. كمان .. كمان + +217 +00:20:55,620 --> 00:20:59,740 +ماشي بقى ماشي بقى ماشي بقى ماشي بقى ماشي بقى ماشي + +218 +00:20:59,740 --> 00:21:04,580 +بقى + +219 +00:21:19,600 --> 00:21:25,220 +دكتور التاني ليش هيك تيجي صوت مع بعض؟ تاني واحدة + +220 +00:21:25,220 --> 00:21:30,710 +تاني قيمةبعد ما قصتش عشان طالع بيبقى سنة اثنان + +221 +00:21:30,710 --> 00:21:37,650 +اثنان اثنان اثنان اثنان اثنان اثنان اثنان اثنان + +222 +00:21:37,650 --> 00:21:37,730 +اثنان اثنان اثنان اثنان اثنان اثنان اثنان اثنان + +223 +00:21:37,730 --> 00:21:37,830 +اثنان اثنان اثنان اثنان اثنان اثنان اثنان اثنان + +224 +00:21:37,830 --> 00:21:38,190 +اثنان اثنان اثنان اثنان اثنان اثنان اثنان اثنان + +225 +00:21:38,190 --> 00:21:41,890 +اثنان اثنان اثنان اثنان اثنان اثنان اثنان اثنان + +226 +00:21:41,890 --> 00:21:45,070 +اثنان اثن + +227 +00:21:46,870 --> 00:21:54,670 +Okay now the average according to eleven thousands + +228 +00:21:54,670 --> 00:22:01,510 +minus ten thousands divided by ten thousands okay + +229 +00:22:01,510 --> 00:22:05,130 +and just double it okay + +230 +00:22:08,770 --> 00:22:14,630 +الان اذا كنت تريد ان تقوم بالتقارير بالمقارنة تقول + +231 +00:22:14,630 --> 00:22:18,410 +ان هذا + +232 +00:22:18,410 --> 00:22:21,290 +مقارنة اذا كنت تريد ان تقوم بالتقارير بالمقارنة + +233 +00:22:21,290 --> 00:22:24,770 +اذا كنت تريد ان تقوم بالتقارير بالمقارنة اذا كنت + +234 +00:22:24,770 --> 00:22:24,850 +تريد ان تقوم بالتقارير بالمقارنة اذا كنت تريد ان + +235 +00:22:24,850 --> 00:22:26,790 +اذا كنت تريد ان تقوم بالتقارير بالمقارنة اذا كنت + +236 +00:22:26,790 --> 00:22:29,530 +تريد ان تقوم بالمقار + +237 +00:22:32,410 --> 00:22:41,970 +8% اذا + +238 +00:22:41,970 --> 00:22:46,230 +كنا نعمل تخطيط الجيومتريك + +239 +00:22:51,140 --> 00:22:59,480 +the geometric fortunately the excel help us to use + +240 +00:22:59,480 --> 00:23:05,020 +geometric because it has built in function built + +241 +00:23:05,020 --> 00:23:08,380 +in function so they have function so just little + +242 +00:23:08,380 --> 00:23:13,500 +change because geometricلن تقبل القيم بالصين + +243 +00:23:13,500 --> 00:23:16,580 +المفقودة، لذلك يجب أن نحاول أن نفعلها بطريقة + +244 +00:23:16,580 --> 00:23:20,180 +مختلفة، إنها نفس الشيء، يمكنك أن تفعلها في عادية + +245 +00:23:20,180 --> 00:23:23,700 +أيضًا، يمكنك أن تفعل هذا في عادية، سأريك كيف يعمل + +246 +00:23:23,700 --> 00:23:31,080 +في عادية، حسنًا، بي وان مقاطع بي نوت، حسنًا؟ + +247 +00:23:33,080 --> 00:23:37,380 +عن طريق التخطيط الجيومتريك هو جيومتريك فقط تختار + +248 +00:23:37,380 --> 00:23:45,220 +جيومتريك حسنا و اضغط على هذا و اغلق هذا اقل من + +249 +00:23:45,220 --> 00:23:50,960 +واحد هذا هو الجيومتريك يمكنك تطبيق الجيومتريك عادة + +250 +00:23:50,960 --> 00:23:56,260 +على هذا لا يجب عليك التخطيط هذا سأريك كيف يعمل + +251 +00:23:56,260 --> 00:24:01,440 +حسنا اترك هذا اذا لم نكن لديه هذا حسنا + +252 +00:24:03,570 --> 00:24:09,710 +it's equal the average okay this is the average + +253 +00:24:09,710 --> 00:24:18,530 +minus one that's it okay so this is the average + +254 +00:24:18,530 --> 00:24:23,210 +rate of return and this is the geometric + +255 +00:24:29,560 --> 00:24:35,600 +Okay as we observe the geometric is this time okay + +256 +00:24:35,600 --> 00:24:39,060 +let's + +257 +00:24:39,060 --> 00:24:47,820 +go back to the to our example here remind + +258 +00:24:47,820 --> 00:24:50,100 +me to talk about your assignments in the last five + +259 +00:24:50,100 --> 00:24:55,560 +minutes okay if you want to to draw the charts for + +260 +00:24:55,560 --> 00:24:58,600 +this one okay in excel + +261 +00:25:01,590 --> 00:25:06,810 +مهم ان تستخدم مهارتك + +262 +00:25:06,810 --> 00:25:18,710 +حسنا، + +263 +00:25:18,710 --> 00:25:23,550 +هذا الـ chart في اكسل هذه السنة من .. يمكنك تغيير + +264 +00:25:23,550 --> 00:25:27,950 +السنة من 0 إلى 4 يمكنك تغييرها إلى P + +265 +00:25:36,650 --> 00:25:42,090 +تغييرهم لكي يكونون واحدة لذلك في السنة واحدة هنا + +266 +00:25:42,090 --> 00:25:46,170 +هذه السنة أزرع سنة واحدة ثم اثنان اثنان اثنان + +267 +00:25:46,170 --> 00:25:48,050 +اثنان اثنان اثنان اثنان اثنان اثنان اثنان اثنان + +268 +00:25:48,050 --> 00:25:48,610 +اثنان اثنان اثنان اثنان اثنان اثنان اثنان اثنان + +269 +00:25:48,610 --> 00:25:50,030 +اثنان اثنان اثنان اثنان اثنان اثنان اثنان اثنان + +270 +00:25:50,030 --> 00:25:50,050 +اثنان اثنان اثنان اثنان اثنان اثنان اثنان اثنان + +271 +00:25:50,050 --> 00:26:01,610 +اثنان اثنان اثن + +272 +00:26:03,320 --> 00:26:08,800 +هي أعلى من هذه المنطقة هنا تان فيتا وهذا من ناحية + +273 +00:26:08,800 --> 00:26:14,060 +الارثماتيكية دعونا نرى كيف تعمل لنرى بالضبط + +274 +00:26:14,060 --> 00:26:18,480 +مايعنيه ماهي الفرق بين الجيومتريك والارثماتيكي + +275 +00:26:18,480 --> 00:26:23,160 +الجيومتريك هو المتحرك من هذا النقطة إلى هذا النقطة + +276 +00:26:25,030 --> 00:26:29,430 +ونعتبر هذا حركة عضوية وهذا البرامج هي البرامج من + +277 +00:26:29,430 --> 00:26:31,510 +هنا إلى هذا النقطة لكن + +278 +00:26:31,510 --> 00:26:47,550 +الاريثماتيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكيكي + +279 +00:26:50,080 --> 00:26:55,720 +هذه اللحظة تعتبرها جيومتريكيا أو تعتبرها رحلات + +280 +00:26:55,720 --> 00:27:03,760 +البرامج و .. + +281 +00:27:03,760 --> 00:27:06,560 +أعتقد أن هناك بعض الأشياء المتحركة في الجانب + +282 +00:27:06,560 --> 00:27:11,160 +العام، حسنًا؟ فهذه هي فكرة جيومتريكيا تقارن مع + +283 +00:27:11,160 --> 00:27:16,380 +البرامج العلمية حسنًا؟ + +284 +00:27:20,480 --> 00:27:26,540 +ونرى الانتقال من هذا ونجيب + +285 +00:27:26,540 --> 00:27:37,360 +المشكلة هذا مثال أخر، هذا مثال أخر، يمكنك تطبيقه + +286 +00:27:37,360 --> 00:27:43,700 +مثل هذا يبدأ من 10 ألف ويمكنك تطبيقه مثل هذا + +287 +00:27:46,690 --> 00:27:50,850 +What determines the stock prices؟ this is very + +288 +00:27:50,850 --> 00:27:58,290 +important and this is a big question what + +289 +00:27:58,290 --> 00:28:03,730 +determines the stock prices؟ information okay you + +290 +00:28:03,730 --> 00:28:08,710 +are right information what + +291 +00:28:08,710 --> 00:28:10,930 +else? + +292 +00:28:11,770 --> 00:28:16,920 +what do you mean by information?sorry? information + +293 +00:28:16,920 --> 00:28:19,360 +about the market information about the market, so + +294 +00:28:19,360 --> 00:28:22,980 +if you want to invest in Peltel you are looking on + +295 +00:28:22,980 --> 00:28:26,220 +information about the markets, not Peltel يعني + +296 +00:28:26,220 --> 00:28:30,720 +بشكل عام In general, what is the information you + +297 +00:28:30,720 --> 00:28:33,980 +are looking for? about the stocks, the price of + +298 +00:28:33,980 --> 00:28:39,360 +the stocks you are right, but I want to know what + +299 +00:28:39,360 --> 00:28:44,640 +is the level of your in-depth understandingمعلومات + +300 +00:28:44,640 --> 00:28:49,840 +حسنا اذا تتكلم عن بالتل المعلومات كم عميل يعملون + +301 +00:28:49,840 --> 00:28:54,960 +في بالتل؟ لا حسنا لا ماهي ايجار بالتل؟ نعم تتكلم + +302 +00:28:54,960 --> 00:28:59,340 +عن هذا حسنا كم عميل مستخدم؟ كم عميل مستخدم؟ نعم + +303 +00:28:59,340 --> 00:29:08,640 +حسنا سوف يؤثر على شركاتي أو ما فيها حسنا نعم تتكلم + +304 +00:29:08,640 --> 00:29:15,020 +عن المال؟ نعم نعم نعميمكنك تحدث عن مصطلح الدفع + +305 +00:29:15,020 --> 00:29:21,920 +يمكنك تحدث عن مقارنة المصالح يمكنك تحدث عنها هذه + +306 +00:29:21,920 --> 00:29:26,740 +المعلومات الأساسية لذلك يمكننا أن نختار المعلومات + +307 +00:29:26,740 --> 00:29:32,400 +إلى ثلاث مستوى أساسي المعلومات التاريخية عن تجارب + +308 +00:29:32,400 --> 00:29:38,620 +السعر يمكننا أن نتحدث عن المعلومات الأساسية التي + +309 +00:29:38,620 --> 00:29:41,120 +متوفرة بشكل عام للمستخدمين + +310 +00:29:42,640 --> 00:29:47,240 +و نستطيع أن نتكلم عن المعلومات الحقيقية المعلومات + +311 +00:29:47,240 --> 00:29:49,760 +الحقيقية، المعلومات الحقيقية، هذا النوع من + +312 +00:29:49,760 --> 00:29:54,120 +المعلومات هي للدراسين، + +313 +00:29:54,120 --> 00:29:58,420 +أنا لا أقصد أن الدراسين، الناس الذين يعملون في + +314 +00:29:58,420 --> 00:30:05,040 +الشبكة، إنها ليست مثل هذا، إنها يعني حتى الشرفات + +315 +00:30:05,040 --> 00:30:08,740 +اللي لم يكنوا يعرفوا، وميكانيزمات السوق المالي + +316 +00:30:10,130 --> 00:30:15,350 +الناس لديها الـ Speculators لديها الـ Insiders + +317 +00:30:15,350 --> 00:30:23,350 +لدعونا نرى ال Dealers + +318 +00:30:24,640 --> 00:30:29,860 +يمكنه أن يعرف مستوى المطاولة والتطبيق على مجموعات + +319 +00:30:29,860 --> 00:30:34,140 +معينة، هذا في المعلومات الداخلية، وسنشرح هذا في + +320 +00:30:34,140 --> 00:30:37,380 +الانتجارات في التفاصيل أو في التفاصيل في + +321 +00:30:37,380 --> 00:30:45,680 +الانتجارات، ماذا يعني بالضبط المعلومات؟ فالسعر + +322 +00:30:45,680 --> 00:30:49,420 +عامًا يتم تأثيره بالمعلومات + +323 +00:30:51,710 --> 00:31:00,390 +والإعلان مرتبط بشركات الانتجار الانتجار + +324 +00:31:00,390 --> 00:31:01,850 +الانتجار الانتجار الانتجار الانتجار الانتجار + +325 +00:31:01,850 --> 00:31:02,110 +الانتجار الانتجار الانتجار الانتجار الانتجار + +326 +00:31:02,110 --> 00:31:02,290 +الانتجار الانتجار الانتجار الانتجار الانتجار + +327 +00:31:02,290 --> 00:31:02,350 +الانتجار الانتجار الانتجار الانتجار الانتجار + +328 +00:31:02,350 --> 00:31:02,670 +الانتجار الانتجار الانتجار الانتجار الانتجار + +329 +00:31:02,670 --> 00:31:15,830 +الانتجار الانتجار الانتجار الانتجار الانتجار ال + +330 +00:31:21,380 --> 00:31:24,840 +people influenced in the bad news more than in the + +331 +00:31:24,840 --> 00:31:30,500 +good news for instance yes if you have issues of + +332 +00:31:30,500 --> 00:31:34,780 +your friends you influenced issues like concerns + +333 +00:31:34,780 --> 00:31:38,000 +if you have trouble with your friends you remember + +334 +00:31:38,000 --> 00:31:40,620 +these issues more than if you have a good + +335 +00:31:40,620 --> 00:31:42,300 +friendship + +336 +00:31:44,330 --> 00:31:47,830 +الناس تفكير الأخبار السيئة أكتر من الأخبار الجيدة، + +337 +00:31:47,830 --> 00:31:51,050 +فإن عدد الأخبار الجيدة أقل من عدد الأخبار السيئة + +338 +00:31:51,050 --> 00:31:54,630 +ليس عددها أقل من عددها أقل من عددها أقل من عددها + +339 +00:31:54,630 --> 00:31:54,870 +أقل من عددها أقل من عددها أقل من عددها أقل من + +340 +00:31:54,870 --> 00:31:56,950 +عددها أقل من عددها أقل من عددها أقل من عددها أقل + +341 +00:31:56,950 --> 00:31:57,270 +من عددها أقل من عددها أقل من عددها أقل من عددها + +342 +00:31:57,270 --> 00:31:59,050 +أقل من عددها أقل من عددها أقل من عددها أقل من + +343 +00:31:59,050 --> 00:32:03,940 +عددها أقل من عددها أقل من عددها أقفي نهاية اليوم + +344 +00:32:03,940 --> 00:32:07,600 +كانت تتفضل الأخبار السيئة والأخبار الجيدة، ولكن + +345 +00:32:07,600 --> 00:32:11,600 +الناس عندما تأخذ القرارات تتفضلوا أكتر على الأخبار + +346 +00:32:11,600 --> 00:32:16,540 +السيئة من الأخبار الجيدة. منذ أن شركات الولايات + +347 +00:32:16,540 --> 00:32:20,000 +المتحدة عملوا بشكل جيد عامًا في السنوات السادسة، + +348 +00:32:20,000 --> 00:32:25,900 +عادات السوق كانت مفيدة أيضًا.هذا يجعلنا نتكلم عن + +349 +00:32:25,900 --> 00:32:30,180 +الهيبوتسيس الواقعي، إذا كنا نتكلم عن المعلومات، + +350 +00:32:30,180 --> 00:32:34,140 +بعض الشركات تتفرج المعلومات بشكل صحيح، وغير ذلك لا + +351 +00:32:34,140 --> 00:32:39,560 +تتفرج المعلومات، لذلك لدينا عاملات واقعية وليس + +352 +00:32:39,560 --> 00:32:46,320 +واقعية، عاملات واقعية تتفرج المعلوماتباعتبار هذا + +353 +00:32:46,320 --> 00:32:50,500 +المفهوم، قمنا بإعجاب محافظات أفضل إلى ثلاثة + +354 +00:32:50,500 --> 00:32:57,300 +مقالات، فإعجاب محافظة الأفضل تقول بأن أسعار + +355 +00:32:57,300 --> 00:33:02,040 +الحماية تتضمن بشكل صحيح أسعار المال المتوقع من + +356 +00:33:02,040 --> 00:33:08,580 +المستقبل، لذلك المعلومات تساعدنا في توقيع مستقبل + +357 +00:33:08,580 --> 00:33:09,000 +المستقبل المستقبل المستقبل المستقبل المستقبل + +358 +00:33:09,000 --> 00:33:09,500 +المستقبل المستقبل المستقبل المستقبل المستقبل + +359 +00:33:09,500 --> 00:33:11,000 +المستقبل المستقبل المستقبل المستقبل المستقبل + +360 +00:33:11,000 --> 00:33:12,860 +المستقبل المستقبل المستقبل المستقبل المستقبل + +361 +00:33:12,860 --> 00:33:12,900 +المستقبل المستقبل المستقبل المستقبل المستقبل + +362 +00:33:12,900 --> 00:33:15,140 +المستقبل المستقبل المستقبل المالـ Efficient Market + +363 +00:33:15,140 --> 00:33:18,560 +هو مجتمع فيه جميع المعلومات المتوفرة، جميع + +364 +00:33:18,560 --> 00:33:22,420 +المعلومات المتوفرة، بما في ذلك المعلومات الخاصة، + +365 +00:33:22,420 --> 00:33:25,360 +المعلومات المتوفرة للجمهور والمعلومات التاريخية، + +366 +00:33:25,360 --> 00:33:29,480 +هذه المعلومات يجب أن تكون تفكيرة في قيمة الأسعار + +367 +00:33:31,090 --> 00:33:38,190 +وهذا فقط، إنه أيضًا سرعة التي تتواصل مع هذه + +368 +00:33:38,190 --> 00:33:43,050 +المعلومات، لذلك لدينا اتفاقين، الأول هو أن + +369 +00:33:43,050 --> 00:33:46,810 +المعلومات تتواصل مع السعر، والاتفاق الثاني هو + +370 +00:33:46,810 --> 00:33:51,760 +السرعة التي تتواصل مع المعلوماتولكن هذا لأن هذا + +371 +00:33:51,760 --> 00:33:57,140 +كتاب أساسي جدًا، فهو فقط يعتبر إذا كانت المعلومات + +372 +00:33:57,140 --> 00:34:02,400 +مظهرة في السعر أو لا، في كتابات أخرى يتكلمون عن + +373 +00:34:02,400 --> 00:34:09,360 +سرعة تحسين السعرماركت افضل هو ماركت فيها كل + +374 +00:34:09,360 --> 00:34:12,240 +المعلومات المتوفرة تم تشغيلها تماما في أسعار + +375 +00:34:12,240 --> 00:34:17,240 +الأمانات وإعادة المستخدمين إلى الاستثمار لا يمكن + +376 +00:34:17,240 --> 00:34:21,920 +تخطيطها، لا يمكنك تخطيطها حتى لو كانت لديك + +377 +00:34:21,920 --> 00:34:26,660 +إعلانات، انت هنا لإعلاناتك، لذلك صعب تخطيط أين + +378 +00:34:26,660 --> 00:34:31,440 +يذهب الأسعار وهذا يذكرنا أن نتكلم عن الـRandom + +379 +00:34:31,440 --> 00:34:39,490 +Walkإذا كنا نتكلم عن الأسعار في السوق، فسيبقى + +380 +00:34:39,490 --> 00:34:44,430 +الأسعار في مجموعة محددة، لا تعرفين ذلك، وكانت هذه + +381 +00:34:44,430 --> 00:34:47,570 +المجموعة في الأسعار الأسعارية ويمكننا أن نسميها + +382 +00:34:47,570 --> 00:34:50,990 +إلى ثلاث مستوى، أسلوب ضعيف، أسلوب مستوي، أسلوب + +383 +00:34:50,990 --> 00:34:55,830 +ضعيف، أسلوب ضعيفوهو مفهوم في قيمة التاريخ + +384 +00:34:55,830 --> 00:35:02,250 +المستقبلي والمفهوم هو + +385 +00:35:02,250 --> 00:35:05,370 +المعلومات المفتوحة ومتوفرة للجمهور ومتوفرة للجمهور + +386 +00:35:05,370 --> 00:35:09,590 +ومتوفرة للجمهور ومتوفرة للجمهور ومتوفرة للجمهور + +387 +00:35:09,590 --> 00:35:18,050 +ومتوفرة للجمهورwe have only in the next meeting on + +388 +00:35:18,050 --> 00:35:20,690 +wednesday just we need 10 minutes 10-15 minutes + +389 +00:35:20,690 --> 00:35:25,350 +and we will finish this chapter okay so see you on + +390 +00:35:25,350 --> 00:35:28,670 +wednesday any question؟ نحكي عن ال assignment yes + +391 +00:35:28,670 --> 00:35:30,390 +okay شكرا + diff --git a/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/L81-Eyv6sr4.srt b/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/L81-Eyv6sr4.srt new file mode 100644 index 0000000000000000000000000000000000000000..2673db876d6902dd4a4ff40aa4f23068a6a5479f --- /dev/null +++ b/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/L81-Eyv6sr4.srt @@ -0,0 +1,1939 @@ +1 +00:00:19,930 --> 00:00:23,330 +بسم الله الرحمن الرحيم الذي قايل فات أنه كنا نحكي + +2 +00:00:23,330 --> 00:00:26,090 +عن ال investment companies نحكي عن ال financial + +3 +00:00:26,090 --> 00:00:29,330 +intermediaries just to remind you about the + +4 +00:00:29,330 --> 00:00:31,730 +financial.. the main financial intermediaries + +5 +00:00:31,730 --> 00:00:35,090 +نشوف + +6 +00:00:35,090 --> 00:00:37,910 +من هم ال main financial intermediaries commercial + +7 +00:00:37,910 --> 00:00:45,570 +banks خليني أشوف investment companies هاي investment + +8 +00:00:45,570 --> 00:00:49,070 +companies investment companies investment + +9 +00:00:49,070 --> 00:00:58,690 +companies industrial banks و ال agricultural banks + +10 +00:00:58,690 --> 00:01:06,850 +what else we have more financial investment banks yes + +11 +00:01:06,850 --> 00:01:13,870 +investment banks okay what what else finance + +12 +00:01:13,870 --> 00:01:20,170 +companies yeah finance companies corporate companies we + +13 +00:01:20,170 --> 00:01:28,890 +still have mutual funds mutual funds what else + +14 +00:01:28,890 --> 00:01:36,610 +hedge funds yes hedge funds exchange traded funds yeah exchange + +15 +00:01:36,610 --> 00:01:42,130 +traded funds exchange traded funds ETFs exchange + +16 +00:01:42,130 --> 00:01:47,710 +traded funds okay so most of them are financial + +17 +00:01:47,710 --> 00:01:51,610 +institutions play as financial intermediaries to + +18 +00:01:51,610 --> 00:01:54,090 +facilitate the relationship between savers and + +19 +00:01:54,090 --> 00:01:59,650 +borrowers okay any question about these financial + +20 +00:01:59,650 --> 00:02:01,610 +institutions no + +21 +00:02:08,430 --> 00:02:17,650 +الشركات الاستثمارية هي شركات تستثمر موارد الشخصيات + +22 +00:02:17,650 --> 00:02:21,610 +والعمل في شركات مجتمعات جديدة كما ترى هنا، هي + +23 +00:02:21,610 --> 00:02:25,790 +المجتمعات المالية التي تجمع موارد الشخصيات والعمل + +24 +00:02:25,790 --> 00:02:31,450 +وتستثمر المال في الأصول المشهودة من شركات أخرى + +25 +00:02:31,450 --> 00:02:39,560 +فقط لشركات استثمارية هذه الشركات فقط تجمع المساعدة + +26 +00:02:39,560 --> 00:02:44,040 +من المستخدمين و تقوم بالاستثمار في شركات أخرى لشركات + +27 +00:02:44,040 --> 00:02:47,200 +الاستثمار هذه هي المركز الرئيسي لشركات + +28 +00:02:47,200 --> 00:02:51,600 +الاستثمارية في + +29 +00:02:51,600 --> 00:02:57,220 +الشركات الاستثمارية أيضًا لدينا مصارف مصارف + +30 +00:02:57,220 --> 00:03:00,680 +مصارف مصارف مصارف مصارف مصارف مصارف مصارف مصارف + +31 +00:03:00,680 --> 00:03:01,920 +مصارف مصارف مصارف مصارف مصارف مصارف مصارف مصارف + +32 +00:03:01,920 --> 00:03:02,000 +مصارف مصارف مصارف مصارف مصارف مصارف مصارف مصارف + +33 +00:03:02,000 --> 00:03:02,420 +مصارف مصارف مصارف مصارف مصارف مصارف مصارف مصارف + +34 +00:03:02,420 --> 00:03:12,190 +مصارف مصارف مصارف mutual funds stating + +35 +00:03:12,190 --> 00:03:15,750 +a particular objective they have their own + +36 +00:03:15,750 --> 00:03:20,710 +objective let's consider one of their objectives to + +37 +00:03:20,710 --> 00:03:25,170 +invest in + +38 +00:03:25,170 --> 00:03:31,550 +telecommunications in + +39 +00:03:31,550 --> 00:03:35,710 +Ghana okay + +40 +00:03:36,520 --> 00:03:41,600 +هذا هو الهدف الرئيسي لتطوير التجارب التجارية في + +41 +00:03:41,600 --> 00:03:49,880 +غانا و هم يبحثون عن أموال من المستخدمين الصغير و + +42 +00:03:49,880 --> 00:03:54,540 +تعتبر أن المستخدم الصغير فقط لديه 100 دولار فإذا + +43 +00:03:54,540 --> 00:04:00,440 +كان لديك 100 دولار يمكنك + +44 +00:04:00,440 --> 00:04:06,100 +أن تستخدم الممارسات التي تجمع 100 دولار من + +45 +00:04:06,100 --> 00:04:10,220 +المستخدمين، ربما 200، 100، لكن على الأقل قيمة الـ + +46 +00:04:10,220 --> 00:04:17,020 +net asset value وسأتحدث عن هذا، قيمة ال net asset value تبدأ + +47 +00:04:17,020 --> 00:04:21,660 +من 100 دولار وتهدف المستخدمين الصغيرين، لأن + +48 +00:04:21,660 --> 00:04:26,250 +المستخدم الصغير لا يمكن أن يشتري الـ 100 دولار + +49 +00:04:26,250 --> 00:04:30,990 +مباشرة من السوق المالي، فالأموال المالية تعطيه + +50 +00:04:30,990 --> 00:04:34,730 +فرصة لتقليل المالية باستخدام الأموال المالية + +51 +00:04:34,730 --> 00:04:37,370 +باستخدام الأموال المالية باستخدام الأموال المعلقة + +52 +00:04:37,370 --> 00:04:38,090 +أو المعلقة من قبل + +53 +00:04:41,290 --> 00:04:47,010 +وعندما يحصلوا على هذا المبلغ، يدخلوا إلى غانا + +54 +00:04:47,010 --> 00:04:53,330 +ويبدأوا بالاستثمار وهذه الأجهزة، الـ 100 دولار، + +55 +00:04:53,330 --> 00:05:00,150 +معروفة كـ Net Asset Value وهو محسوب على أساس أسعار + +56 +00:05:00,150 --> 00:05:05,940 +اليومية، والمستخدمين يستطيعون أن يشتروا و يبيعوا قيمة + +57 +00:05:05,940 --> 00:05:12,820 +لأسهمهم كل يوم إذا كنت تريد أن تخلص شركتك من + +58 +00:05:12,820 --> 00:05:17,240 +المال الموجود فانت بسهولة تفعلها في السوق المالي أو في + +59 +00:05:17,240 --> 00:05:21,660 +المال الموجود فالمال الموجود فالمال الموجود فالمال الموجود فالمال الموجود فالمال الموجود + +60 +00:05:21,660 --> 00:05:24,540 +فالمال الموجود فالمال الموجود فالمال الموجود فالمال الموجود فالمال الموجود فالمال الموجود + +61 +00:05:24,540 --> 00:05:24,820 +فالمال الموجود فالمال الموجود فالمال الموجود فالمال الموجود فالمال الموجود فالمال الموجود + +62 +00:05:24,820 --> 00:05:24,900 +فالمال الموجود فالمال الموجود فالمال الموجود فالمال الموجود فالمال الموجود فالمال الموجود + +63 +00:05:24,900 --> 00:05:26,300 +فالمال الموجود فالمال الموجود فالمال الموجود فالمال الموجود فالمال الموجود فالمال الموجود + +64 +00:05:26,750 --> 00:05:30,890 +individuals meaning small investors can invest in + +65 +00:05:30,890 --> 00:05:33,350 +mutual funds by buying shares in the mutual fund + +66 +00:05:33,350 --> 00:05:38,190 +at net asset value net asset value is calculated + +67 +00:05:38,190 --> 00:05:42,370 +daily based on the total value of the fund divided + +68 +00:05:42,370 --> 00:05:45,230 +by the number of mutual fund shares outstanding + +69 +00:05:45,230 --> 00:05:50,470 +okay let's for instance take this example here how + +70 +00:05:50,470 --> 00:05:52,230 +they calculated the net asset value + +71 +00:05:55,610 --> 00:06:00,150 +دعونا نرى أنهم جمعوا 100 دولار 300 دولار وكذلك + +72 +00:06:00,150 --> 00:06:08,350 +لذلك الآن هي 5 مليون دولار أنتجوها إلى شرائح، فـ 5 + +73 +00:06:08,350 --> 00:06:16,030 +مليون دفع 5 مليون شرائح، فهي 1 دولار على سبيل + +74 +00:06:16,030 --> 00:06:23,370 +المثال، فهذه شريحة واحدة اسمها قيمة نت أسيط نت + +75 +00:06:23,370 --> 00:06:29,010 +أسيط قيمة هذه المجموعة الواحدة تسمى في الماليات + +76 +00:06:29,010 --> 00:06:33,530 +المالية كـ one net asset value أنهم يبدأوا بالعمل + +77 +00:06:33,530 --> 00:06:38,110 +يقوموا بالاستثمار في غانا ويجعلوا أرباح فهذا يعني + +78 +00:06:38,110 --> 00:06:44,090 +أن قيمة الماليات المالية تزداد دعونا نقول إنها + +79 +00:06:44,090 --> 00:06:51,670 +تزداد حتى سبع مليون دفع سبع مليون إلى خمس مليون + +80 +00:06:53,760 --> 00:06:58,620 +القيم الـ net asset value فقط قمت بتقسيم هذا الـ 7 إلى 5 + +81 +00:06:58,620 --> 00:07:07,140 +ستأخذ القيم هذا هو قيم قيم net asset value وهذا يعتمد + +82 +00:07:07,140 --> 00:07:11,420 +على العمل اليومي إذا كنت تريد أن تبيعه الآن أو + +83 +00:07:11,420 --> 00:07:12,840 +يوميا يمكنك أن تفعل ذلك + +84 +00:07:15,760 --> 00:07:19,440 +نحن لدينا أعتقد اتفاقين مختلفين من mutual funds نحن + +85 +00:07:19,440 --> 00:07:23,920 +لدينا mutual funds و no load mutual funds و سن .. + +86 +00:07:23,920 --> 00:07:26,140 +الاختلاف الرئيسي بين mutual funds و no load mutual funds + +87 +00:07:26,140 --> 00:07:29,820 +و no load mutual funds هو الكميشن في ال .. في ال mutual + +88 +00:07:29,820 --> 00:07:34,500 +funds أنت تشتري و تبيع من خلال البروكر لذا يجب أن + +89 +00:07:34,500 --> 00:07:38,840 +تدفع كميشن لكن في ال mutual funds و no load mutual funds + +90 +00:07:38,840 --> 00:07:43,640 +أنت تشتري و تبيع مباشرة مع mutual funds أو مع شركة + +91 +00:07:43,640 --> 00:07:56,070 +الاستثمار و لا تدفع أي مدفوعات إذا كما أشرح هنا نحن + +92 +00:07:56,070 --> 00:07:59,350 +لدينا mutual funds مشابه لـ mutual funds مشابه + +93 +00:07:59,350 --> 00:08:02,530 +لـ mutual funds مشابه لـ mutual funds مشابه لـ mutual funds + +94 +00:08:02,530 --> 00:08:03,790 +لـ mutual funds مشابه لـ mutual funds مشابه لـ mutual funds + +95 +00:08:03,790 --> 00:08:05,910 +لـ mutual funds مشابه لـ mutual funds مشابه لـ mutual funds + +96 +00:08:05,910 --> 00:08:05,930 +لـ mutual funds مشابه لـ mutual funds مشابه لـ mutual funds + +97 +00:08:05,930 --> 00:08:10,150 +لـ mutual funds مشابه + +98 +00:08:10,150 --> 00:08:11,530 +لـ mutual funds مشابه لمص + +99 +00:08:15,790 --> 00:08:22,790 +نحن نتكلم عن شركات الاستثمارات شركات + +100 +00:08:22,790 --> 00:08:29,350 +الاستثمارات مسؤولة في إصدار mutual funds mutual funds وهذه + +101 +00:08:29,350 --> 00:08:37,450 +mutual funds mutual funds وإصدار ETFs مختلفة + +102 +00:08:37,450 --> 00:08:41,970 +الفرق الرئيسي بين mutual funds mutual funds و ETFs المال الموجود فان يمكن أن + +103 +00:08:41,970 --> 00:08:46,830 +يتم شراءها من خلال الـ mutual funds أو من خلال الـ mutual funds أو + +104 +00:08:46,830 --> 00:08:53,070 +من خلال الـ mutual funds نفسها صندوق السمارة تروح مباشرة على + +105 +00:08:53,070 --> 00:08:55,890 +مدير الصندوق تشتري و تبيع منه أو تروح على الـ mutual funds + +106 +00:08:55,890 --> 00:08:59,290 +هي اللي أسست الصندوق و تشتري مباشرة + +107 +00:08:59,290 --> 00:09:05,430 +however the ETFs you have to trade ETFs through the + +108 +00:09:05,430 --> 00:09:06,270 +financial market + +109 +00:09:09,430 --> 00:09:13,650 +من مجتمع الأسعار التي تسمى Exchange Traded Funds هي + +110 +00:09:13,650 --> 00:09:16,570 +مشابهة لـ Mutual Fund إلا أن الـ ownership shares + +111 +00:09:16,570 --> 00:09:19,610 +في الـ ETFs يمكن أن يتم شراؤها ويتم استخدامها في مجتمع + +112 +00:09:19,610 --> 00:09:28,010 +الأسعار عامة ETFs تدخل.. قبل أن أشرح هذا في + +113 +00:09:28,010 --> 00:09:34,250 +مجموعات الاستثمارات في ETFs ماذا يفعلون بالضبط ETFs + +114 +00:09:34,250 --> 00:09:37,730 +هم + +115 +00:09:37,730 --> 00:09:46,580 +مجموعات تدخل تصميم البورفوليو تعتمد + +116 +00:09:46,580 --> 00:09:50,440 +على مؤشر مؤشر + +117 +00:09:50,440 --> 00:09:50,500 +تعتمد على مؤشر تعتمد على مؤشر تعتمد على مؤشر + +118 +00:09:50,500 --> 00:09:52,820 +تعتمد على مؤشر تعتمد على مؤشر تعتمد على مؤشر + +119 +00:09:52,820 --> 00:09:54,720 +تعتمد على مؤشر تعتمد على مؤشر تعتمد على مؤشر + +120 +00:09:54,720 --> 00:09:55,520 +تعتمد على مؤشر تعتمد على مؤشر تعتمد على مؤشر + +121 +00:09:55,520 --> 00:09:55,720 +تعتمد على مؤشر تعتمد على مؤشر تعتمد على مؤشر + +122 +00:09:55,720 --> 00:09:56,720 +تعتمد على مؤشر تعتمد on index تعتمد on index + +123 +00:09:56,720 --> 00:10:04,760 +تعتمد on index تعتمد on index تعتمد on + +124 +00:10:06,370 --> 00:10:13,830 +Paris Stock Exchange لديها مؤشر هذا المؤشر يمثل + +125 +00:10:13,830 --> 00:10:18,490 +الشركات الموجودة في السوق المالي الموجودة هنا + +126 +00:10:18,490 --> 00:10:24,550 +Paris Stock Exchange لديها حوالي 40 شركة أو أكثر + +127 +00:10:24,550 --> 00:10:31,930 +من 40 شركة من 1,2,3 إلى 40 شركة عندما يرغبون في + +128 +00:10:31,930 --> 00:10:36,610 +بناء المؤشر، الـ index, they selected the best for + +129 +00:10:36,610 --> 00:10:41,710 +instance the best ten companies in the index and + +130 +00:10:41,710 --> 00:10:47,050 +bought it in the index why they forming up index? + +131 +00:10:47,630 --> 00:10:49,750 +because index giving the direction of the + +132 +00:10:49,750 --> 00:10:54,990 +financial market هو مثل أفضل 10 شركات في السوق + +133 +00:10:54,990 --> 00:11:00,230 +المالي أنا لا أحتاج أن أعتبر كل الشركات الموجودة + +134 +00:11:00,230 --> 00:11:03,910 +في السوق المالي بقى فقط أحتاج أن أخذ أفضل 10 شركات + +135 +00:11:03,910 --> 00:11:10,690 +وهذه الأفضل 10 شركات تعتبر كإشارة للعمل أخذ مثال + +136 +00:11:10,690 --> 00:11:17,550 +آخر دعونا نرى لندن Stock Exchange لندن Stock + +137 +00:11:17,550 --> 00:11:23,960 +Exchange الـ LSE كان لديه أكثر من 5000 شركة، واحد، + +138 +00:11:23,960 --> 00:11:27,480 +اثنان، أكثر من خمس أو أكثر من 6000 شركة، والآن + +139 +00:11:27,480 --> 00:11:33,560 +نريد أن نبني Index، فإن Index يعرف باسم FTSE 100 + +140 +00:11:34,690 --> 00:11:39,670 +sorry for the index of Palestine is known as القدس + +141 +00:11:39,670 --> 00:11:44,610 +index مؤشر القدس for the London Stock Exchange they + +142 +00:11:44,610 --> 00:11:49,770 +call it the 4100 Financial Times Stock Exchange 4100 + +143 +00:11:49,770 --> 00:11:54,350 +index so what it means 4100 it means the best one + +144 +00:11:54,350 --> 00:12:00,330 +hundred companies لذلك يأخذونه ويضعوه كإشارة أو + +145 +00:12:00,330 --> 00:12:06,190 +كتابة لذلك الانتجارات أو الـ ATF لا يحتاجون أن + +146 +00:12:06,190 --> 00:12:10,870 +يضيعوا وقتهم يبحثون عن ما هو أفضل لأن السوق + +147 +00:12:10,870 --> 00:12:15,510 +الانتجاري نفسه قام بتوصيل أفضل 100 شركة لذلك إذا + +148 +00:12:15,510 --> 00:12:18,450 +كنت ترغب في الانتجار في الأول 30 تستطيع أن تفعلها + +149 +00:12:18,450 --> 00:12:22,110 +أو إذا كنت ترغب في الانتجار في الأول 50 تستطيع أن + +150 +00:12:22,110 --> 00:12:25,710 +تفعلها أو في الأول 100 تستطيع أن تفعلها أو في + +151 +00:12:25,710 --> 00:12:29,910 +الواقع 250، لأن السوق المالي يرقمهم باعتبار + +152 +00:12:29,910 --> 00:12:36,510 +تجاربهم، خاصة في اقتصاد السوق، لذلك الـ ATF هم + +153 +00:12:36,510 --> 00:12:42,670 +يستثمرون في الانتجارات، حسنًا؟ واحدة من الشرائعات + +154 +00:12:42,670 --> 00:12:48,760 +من الانتجارات هي الخطر القليل لأنك تستثمر مع أفضل + +155 +00:12:48,760 --> 00:12:53,140 +شركات لذا دعنا .. هنا أنت الـ .. الـ .. الـ .. الـ .. + +156 +00:12:53,140 --> 00:12:53,520 +الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ + +157 +00:12:53,520 --> 00:12:53,660 +.. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ + +158 +00:12:53,660 --> 00:12:54,820 +الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ + +159 +00:12:54,820 --> 00:12:55,800 +.. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. + +160 +00:12:55,800 --> 00:12:55,840 +الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ + +161 +00:12:55,840 --> 00:12:57,960 +.. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. + +162 +00:12:57,960 --> 00:12:59,200 +الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ + +163 +00:12:59,200 --> 00:12:59,280 +.. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. + +164 +00:12:59,280 --> 00:12:59,580 +الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ + +165 +00:12:59,580 --> 00:12:59,680 +.. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. + +166 +00:12:59,680 --> 00:13:01,540 +الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ .. الـ + +167 +00:13:01,540 --> 00:13:06,400 +.. + +168 +00:13:06,400 --> 00:13:09,360 +الـ .. الـ .. + +169 +00:13:22,840 --> 00:13:31,040 +SMB 500 the SMB Standard & Poor's 500 Standard & + +170 +00:13:31,040 --> 00:13:35,840 +Poor's 500 يمثل شركة the New York Stock Exchange شركة + +171 +00:13:35,840 --> 00:13:41,220 +the New York Stock Exchange تحتوي على ألف شركات the SMB + +172 +00:13:41,220 --> 00:13:45,360 +500 تحتوي فقط على أول 500 شركات في شركات الولايات + +173 +00:13:45,360 --> 00:13:51,520 +المتحدة لذا لا أحتاج لأستثمار المال في كل جميع + +174 +00:13:51,520 --> 00:13:56,120 +شركات الولايات المتحدة فقط في الأول خمس مائة شركات + +175 +00:13:56,120 --> 00:13:57,940 +إذا أردت أن أقوم بالاستثمار في أول خمس مائة شركات، + +176 +00:13:57,940 --> 00:14:00,660 +أول خمس مائة شركات حسنًا، ثاني أول خمس مائة شركات + +177 +00:14:00,660 --> 00:14:01,480 +حسنًا، ثاني أول خمس مائة شركات حسنًا، ثاني أول خمس + +178 +00:14:01,480 --> 00:14:01,520 +مائة شركات حسنًا، ثاني أول خمس مائة شركات حسنًا، + +179 +00:14:01,520 --> 00:14:01,780 +ثاني أول خمس مائة شركات حسنًا، ثاني أول خمس مائة + +180 +00:14:01,780 --> 00:14:02,860 +شركات حسنًا، ثاني أول خمس مائة شركات حسنًا، ثاني + +181 +00:14:02,860 --> 00:14:18,260 +أول خمس مائة شركات حسنًا، + +182 +00:14:18,260 --> 00:14:27,210 +كما قلت مؤشر فاند و ETF يقدمون طريقة مفيدة + +183 +00:14:27,210 --> 00:14:32,630 +لتحسين وتقليل المخاطر لأننا نقوم بالاستثمار في + +184 +00:14:32,630 --> 00:14:39,990 +شركات مختلفة 100 في مجالين مختلفين هذا في التعامل، + +185 +00:14:39,990 --> 00:14:44,590 +هذا في الغزو، هذا في الانتجار، وهكذا هتش فاند + +186 +00:14:44,590 --> 00:14:48,070 +هتش فاند هو + +187 +00:14:49,550 --> 00:14:55,230 +invest their money in a high-risk investment it + +188 +00:14:55,230 --> 00:15:00,990 +means hedge من اللي اللي what is the type of + +189 +00:15:00,990 --> 00:15:04,510 +people investing in the hedge funds الـ gamblers الـ + +190 +00:15:04,510 --> 00:15:09,510 +gamblers بيعملوا hedging بيعملوا تحوّل فهم بتاخدوا + +191 +00:15:09,510 --> 00:15:12,050 +مخاطر عالية so hedge funds are similar to mutual + +192 +00:15:12,050 --> 00:15:16,100 +funds اعتبارًا هنا، لكنهم يعتمدون على أكثر أكثر أكثر + +193 +00:15:16,100 --> 00:15:16,340 +أكثر أكثر أكثر أكثر أكثر أكثر أكثر أكثر أكثر أكثر + +194 +00:15:16,340 --> 00:15:18,080 +أكثر أكثر أكثر أكثر أكثر أكثر أكثر أكثر أكثر أكثر + +195 +00:15:18,080 --> 00:15:20,020 +أكثر أكثر أكثر أكثر أكثر أكثر أكثر أكثر أكثر أكثر + +196 +00:15:20,020 --> 00:15:22,120 +أكثر أكثر أكثر أكثر أكثر أكثر أكثر أكثر أكثر أكثر + +197 +00:15:22,120 --> 00:15:41,060 +أكثر أكثر أكثر أكثر أكثر أكثر أكثر أكثر أكثر + +198 +00:15:41,180 --> 00:15:46,520 +هم يأخذون الاستثمار للاستمتاع، هل تعرفين هذا؟ هناك + +199 +00:15:46,520 --> 00:15:52,560 +بعض المستثمرين يأخذون الاستثمار كجولة، كاستمتاع، + +200 +00:15:52,560 --> 00:15:56,480 +ليس كاستخدام فوائد فقط، لأن الفوائد يتم حفظها من + +201 +00:15:56,480 --> 00:16:00,820 +المناطق الأخرى، مثل ما يحصل عندما تجول في قطار، + +202 +00:16:00,820 --> 00:16:06,660 +هذا للاستمتاع Okay. Yes, this is a particular + +203 +00:16:06,660 --> 00:16:10,060 +investment. So because of this, they arrange or + +204 +00:16:10,060 --> 00:16:15,920 +they are doing some hedging funds the Private + +205 +00:16:15,920 --> 00:16:21,000 +equity firms, private equity firms, this is a new + +206 +00:16:21,000 --> 00:16:22,260 +business field. + +207 +00:16:25,450 --> 00:16:29,270 +they invest their money in two different areas, in + +208 +00:16:29,270 --> 00:16:33,410 +the first one, in the venture companies, which is a + +209 +00:16:33,410 --> 00:16:38,550 +new companies or a new fields, and this is a unique + +210 +00:16:38,550 --> 00:16:48,500 +field. ولذلك هذه الشركات تجمع لتجمع المال من + +211 +00:16:48,500 --> 00:16:52,300 +المشروع والعمل وتُصَنَّع هذه الأموال لشركات مجتهدة + +212 +00:16:52,300 --> 00:16:59,670 +جديدة ولدينا مثال عظيم مثل Google غوغل بدأت من المال + +213 +00:16:59,670 --> 00:17:04,830 +من .. من هؤلاء الناس، من الـ private equity funds، + +214 +00:17:04,830 --> 00:17:09,690 +لذلك هذه الشركات فقط استخدمتها لكشف شركة جديدة + +215 +00:17:09,690 --> 00:17:14,690 +وليس فقط شركة جديدة، شركة جديدة في تطبيقات جديدة، + +216 +00:17:14,690 --> 00:17:18,790 +تطبيقات جديدة، أفكار جديدة، أفكار جديدة، ومنطقًا + +217 +00:17:18,790 --> 00:17:25,230 +جديدة، حسنًا؟ مجال جديد؟ نعم، مثل الاستثمار في شيء + +218 +00:17:25,230 --> 00:17:32,860 +مثل Facebook هذه الشركات مهتمة بذلك لأنها تتحمل حرصًا + +219 +00:17:32,860 --> 00:17:36,860 +عاليًا والناس لا يعرفون أين تذهب هذه الشركة مثل + +220 +00:17:36,860 --> 00:17:40,860 +أنها تستثمر في WhatsApp لأن هذا مجال جديد والناس + +221 +00:17:40,860 --> 00:17:47,000 +ربما أو ربما لا تقبل هذه الشركة هذه الشركات + +222 +00:17:47,000 --> 00:17:50,140 +الشركات الخاصة تحتوي على اتصالات كاملة وشركات + +223 +00:17:50,140 --> 00:17:52,840 +شركات شركات شركات شركات شركات شركات شركات شركات + +224 +00:17:52,840 --> 00:17:57,720 +شركات شركات و Leveraged Buyout Firms الـ Leveraged + +225 +00:17:57,720 --> 00:18:04,640 +Buyout Firms مختلفة من الـ Venture الـ Leveraged + +226 +00:18:04,640 --> 00:18:09,780 +Buyout Firms هي الشركات التي تتعاني من مشكلة + +227 +00:18:09,780 --> 00:18:14,000 +محددة، فشركات الـ Private Equity Firms تركز على + +228 +00:18:14,000 --> 00:18:19,920 +هذه الشركات وتحاول أن تعطيها بعض المشاركة ومدعومة + +229 +00:18:19,920 --> 00:18:25,620 +لكي تساعدهم to overcome their problems, and when + +230 +00:18:25,620 --> 00:18:30,180 +they pass their problems, they sell these companies + +231 +00:18:30,180 --> 00:18:34,440 +by debts بيبقوا هاب الديون okay, so this is the + +232 +00:18:34,440 --> 00:18:38,530 +main difference between VC and LBO. But the second + +233 +00:18:38,530 --> 00:18:43,110 +company, holding company قابضة يعني شركات التعبير + +234 +00:18:43,110 --> 00:18:45,330 +اللي فيها؟ it's a corporation اه هي it's a corporation + +235 +00:18:45,330 --> 00:18:48,870 +هي شركة عادية okay. بقي suffering يعني بيكون عندهم + +236 +00:18:48,870 --> 00:18:52,710 +مشكلة في الـ .. they are not performing well يعني + +237 +00:18:52,710 --> 00:18:57,410 +زي القابضة شركة corporation مش شرط تبقي you know + +238 +00:18:57,410 --> 00:19:00,800 +what it means holding company. هبتشتري شركات تعبانة + +239 +00:19:00,800 --> 00:19:04,060 +.. تعبانة .. مش شرطك لأ .. يعني أنت بتحكي + +240 +00:19:04,060 --> 00:19:07,200 +Volkswagen شركة قابضة .. بتشتري شركات تعبانة .. + +241 +00:19:07,200 --> 00:19:10,480 +أقول لك شركات تعبانة اشتريها .. أنا أودي .. مش هاللي + +242 +00:19:10,480 --> 00:19:13,580 +شركة أودي .. شركة تعبانة أودي .. Skoda .. + +243 +00:19:13,580 --> 00:19:17,720 +Lamborghini .. مش تعبانين هدول الشركات .. Skoda .. + +244 +00:19:21,350 --> 00:19:25,410 +مش ضروري تكون holding company هذه شركة بتطلع + +245 +00:19:25,410 --> 00:19:28,750 +الشركات اللي في عندها مشاكل بتروح إيا بتشتريها + +246 +00:19:28,750 --> 00:19:33,870 +بالدين، بتروح بتساعدهم، بتقدم لهم مساعدات وكذا + +247 +00:19:33,870 --> 00:19:38,770 +وكذا، performing well، بعدين بتبيعها، بس بالـ + +248 +00:19:38,770 --> 00:19:42,590 +holding companies لأ الـ holding companies they .. + +249 +00:19:42,590 --> 00:19:45,070 +they .. the issue of a holding company is to + +250 +00:19:45,070 --> 00:19:49,520 +control over these companies. يصادروا زي فكرة + +251 +00:19:49,520 --> 00:19:53,640 +Volkswagen .. Volkswagen acquisition .. يعني الـ + +252 +00:19:53,640 --> 00:19:58,060 +Volkswagen كم شركة عندهم؟ عدى الـ VW نفسها والـ + +253 +00:19:58,060 --> 00:20:02,240 +Audi عندهم ويمكن دخلوا على الـ BMW ودخلوا على الـ + +254 +00:20:02,240 --> 00:20:05,380 +limousine وأخروا واشترَوا شركة Skoda .. عبدالله + +255 +00:20:05,380 --> 00:20:10,960 +كمان واشترَوا شركة هاي الـ .. في شركة خامسة اشترَوا + +256 +00:20:10,960 --> 00:20:14,810 +وخمس شركات تحتيهم وهذول شركات مش عاملين صح ولا + +257 +00:20:14,810 --> 00:20:17,790 +لأ؟ دكتور هل بتعني بتشتريها على أي أساس اللي + +258 +00:20:17,790 --> 00:20:21,010 +بتبيعها؟ يعني شخص طيب، مبيّت ولا مبيّت؟ أعطيكي + +259 +00:20:21,010 --> 00:20:25,930 +مثال، هلأ لما الـ .. يعني الله سمح الله، الـ mobile + +260 +00:20:25,930 --> 00:20:30,150 +phone ينكسر، بتلاقي ألف واحد بيديه يشتريه in a lower + +261 +00:20:30,150 --> 00:20:34,410 +price because they will fix it up and sell it in a + +262 +00:20:34,410 --> 00:20:37,870 +higher price. These expert people لإنه they are hiring + +263 +00:20:37,870 --> 00:20:41,610 +expert people هم بيكونوا مشغلين ناس عندهم خبرة + +264 +00:20:42,540 --> 00:20:45,620 +Okay, they diagnose the issues or the problems of + +265 +00:20:45,620 --> 00:20:48,860 +these companies, they are helping them out, okay, + +266 +00:20:49,000 --> 00:20:52,940 +and when they pass the issues or the problems, + +267 +00:20:53,560 --> 00:20:58,180 +they sell it to the investors زي ما أنتم هان + +268 +00:20:58,180 --> 00:21:01,040 +شايفين, venture companies raise money from + +269 +00:21:01,040 --> 00:21:05,220 +investors, particularly wealthy individuals لأن هادي + +270 +00:21:05,220 --> 00:21:08,940 +new ventures, ما نفعش أن احنا نروح .. نروح على new + +271 +00:21:08,940 --> 00:21:13,540 +projects واحنا يعني تعبانين لأن because this new + +272 +00:21:13,540 --> 00:21:16,300 +project is holding a higher risk and we don't know + +273 +00:21:16,300 --> 00:21:20,260 +if it will go on or .. we don't know where is the + +274 +00:21:20,260 --> 00:21:24,280 +future of these companies that they then used to + +275 +00:21:24,280 --> 00:21:27,600 +provide financing for private startup companies + +276 +00:21:27,600 --> 00:21:31,870 +when they are first founded. For example, venture + +277 +00:21:31,870 --> 00:21:37,270 +capital firm Kleiner, Perkins, Caufield & Byers + +278 +00:21:37,270 --> 00:21:41,990 +KPCB was involved in initial financing of Google + +279 +00:21:41,990 --> 00:21:46,190 +يعني Google هذه الشركة أجت من هدول الناس هم اللي + +280 +00:21:46,190 --> 00:21:50,270 +عملوها، طبعًا؟ يعني زي الأفكار الرياضية بتيجي، مين + +281 +00:21:50,270 --> 00:21:53,470 +بتتحمل الموضوع؟ تعالوا، إحنا فكرة رياضية بنعمل + +282 +00:21:53,470 --> 00:21:56,070 +استثمارات في هذا المجال، Google لسه new things + +283 +00:21:56,070 --> 00:22:00,900 +كانت قبل 15 سنة Okay طيب إحنا بنشتغل فيه، تعالوا، + +284 +00:22:00,900 --> 00:22:06,280 +بيحطوا هالنصارى تلعبهم، بي say Google Now شغلتهم، + +285 +00:22:06,280 --> 00:22:09,000 +بعدين شغلة تانية، مش بس هيك بيعملوا على ال + +286 +00:22:09,000 --> 00:22:12,820 +venture، لأ كمان شركات شوية هيك وضعها مش تمام، + +287 +00:22:12,820 --> 00:22:15,840 +بيدخلوا على وضع الشركة، بيساعدوها، leverage + +288 +00:22:15,840 --> 00:22:18,860 +buyouts, acquire established firms that typically + +289 +00:22:18,860 --> 00:22:22,520 +have not been performing very well with the + +290 +00:22:22,520 --> 00:22:25,060 +objective of making them profitable again يعني + +291 +00:22:25,060 --> 00:22:28,340 +رجعوهم for the healthy companies and selling them + +292 +00:22:28,340 --> 00:22:33,100 +وبعدين يبقوهم and LBO typically uses debts to + +293 +00:22:33,100 --> 00:22:35,800 +fund .. هم ايش بيستخدموا؟ بيستخدموا الديون .. ديون + +294 +00:22:35,800 --> 00:22:40,500 +اه .. debt to fund the purchase of a firm يعني + +295 +00:22:40,500 --> 00:22:44,160 +أروحوا بالدايلو عشان يشتروا ال fans ال bio + +296 +00:22:44,160 --> 00:22:48,080 +transactions grow from seven يعني شوف قداشة السرعة + +297 +00:22:48,080 --> 00:22:50,900 +صارت سبعة و نص مليار دولار في الواحد تسعين لخمسمية + +298 +00:22:50,900 --> 00:22:54,780 +مليار دولار ل 2006 صار حجم الاستثمارات في هدول + +299 +00:22:54,780 --> 00:22:58,320 +الشركات جريت احنا يكون عندنا شغلات متخدمة يعني + +300 +00:22:58,320 --> 00:23:03,800 +يكون الشركات تعبانة و كذا و بساعدوهم يعني زي احنا + +301 +00:23:03,800 --> 00:23:07,320 +.. انا كنت يعني ادرست في .. في .. في جامعات + +302 +00:23:07,320 --> 00:23:12,610 +بريطانيا كيف .. يعني في طلاب يكونوا ضعافين بيجوا + +303 +00:23:12,610 --> 00:23:15,910 +يقولولهم تعالوا انتوا ضعاف مش انكم مش ضعاف يعني في + +304 +00:23:15,910 --> 00:23:19,450 +مشكلة عندكم ف they assign a particular teachers + +305 +00:23:19,450 --> 00:23:24,190 +for them بيكون عندهم teachers مخصصين يتعاملوا مع + +306 +00:23:24,190 --> 00:23:29,410 +هدول الطلاب مش ال teachers رعوتهم المباشرين لأ + +307 +00:23:29,410 --> 00:23:33,750 +بقعد معهم okay listen to them بعدين they suggest + +308 +00:23:33,750 --> 00:23:37,980 +things to help them يحاولوا هم يساعدوهم بالاخير to + +309 +00:23:37,980 --> 00:23:40,260 +overcome it is like this company يتعالوا ليش انتوا + +310 +00:23:40,260 --> 00:23:43,300 +تعبانين؟ في challenges، في مشاكل، في managers مش + +311 +00:23:43,300 --> 00:23:48,980 +قوين، نرتبلهم أمورهم وشركات + +312 +00:23:48,980 --> 00:23:51,960 +اللي بتشتغل الشغل هاد prominent اللي private + +313 +00:23:51,960 --> 00:23:55,760 +equity firms include surplus, capital management, + +314 +00:23:56,060 --> 00:24:00,400 +tbh, tbg and caravess group + +315 +00:24:02,440 --> 00:24:06,400 +في حد عنده سؤال على هدول؟ أه كثير رائعين هدول ال + +316 +00:24:06,400 --> 00:24:09,380 +financial institutions ماعرفش أول مرة they said .. + +317 +00:24:09,380 --> 00:24:10,920 +the first time to know about these financial + +318 +00:24:10,920 --> 00:24:19,460 +institutions؟ أه تفضل الشركات اللي بتشجع بتخلي + +319 +00:24:19,460 --> 00:24:24,060 +الشركات بتعبئل شخص مضاد شخص اللي هم يرجع يبيعوها + +320 +00:24:24,060 --> 00:24:29,650 +شخص اللي يرجع يبيعه الشركة طبعا هم أصلا بياخدوهم .. + +321 +00:24:29,650 --> 00:24:33,750 +بتعاقدوا معاهم .. بتعاقدوا معاهم أنه إحنا .. هذه + +322 +00:24:33,750 --> 00:24:36,850 +شغلتنا لأنه أصلا لما يكون الواحد مكسور أو هذا .. + +323 +00:24:36,850 --> 00:24:42,850 +بده حل .. بده حل فبيجي و ب .. بيعملوا عقد معاهم و + +324 +00:24:42,850 --> 00:24:46,270 +بساعدوهم و بالأخير الشرط أنه ي sell them back .. + +325 +00:24:46,270 --> 00:24:49,990 +يبيعوها هذه الشركة زي بالظبط ما كان في .. بتعرفوا + +326 +00:24:49,990 --> 00:24:53,330 +البنك العربي في عمان؟ كان عنده .. كان في بنك .. + +327 +00:24:53,330 --> 00:24:57,580 +أذكر بنك إسلامي أو إش زي هيك كان وضعه مش كتير طبعا + +328 +00:24:57,580 --> 00:25:01,520 +فالبنك العربي قرر ان هم يساعدوا هذا ال bank فعملوا + +329 +00:25:01,520 --> 00:25:03,360 +البنك العربي .. ايه اللي هو البنك العربي الإسلامي + +330 +00:25:03,360 --> 00:25:06,200 +الدولي .. الدولي ال international islamic bank .. + +331 +00:25:06,200 --> 00:25:08,160 +the Arab international islamic bank فهذا ال case + +332 +00:25:08,160 --> 00:25:12,600 +كان .. بيعوا البنك .. كيف انه .. طبعا هم صلحوا + +333 +00:25:12,600 --> 00:25:16,530 +الإدارة تبعه و رتبوا ال bank و بعدين اشتروهم فصار + +334 +00:25:16,530 --> 00:25:21,950 +belong them فهذه الشركات اللي ممكن .. فهم they are + +335 +00:25:21,950 --> 00:25:24,730 +targeting these companies هم بيركزوا على هذه + +336 +00:25:24,730 --> 00:25:30,530 +الشركات دكتور it must be a company yes not a + +337 +00:25:30,530 --> 00:25:34,250 +person no it's a company ليش belong to him؟ لأنه + +338 +00:25:34,250 --> 00:25:38,830 +ليش؟ why بكتوب in a publication last semester a + +339 +00:25:38,830 --> 00:25:42,830 +person but I forget his name that he was buying + +340 +00:25:42,830 --> 00:25:43,730 +companies + +341 +00:25:48,480 --> 00:25:56,390 +scandal of what؟ he always buy .. there is + +342 +00:25:56,390 --> 00:25:58,990 +something for individuals there is something for + +343 +00:25:58,990 --> 00:26:01,690 +individuals there are some companies for + +344 +00:26:01,690 --> 00:26:05,670 +individuals okay but not the private equity + +345 +00:26:05,670 --> 00:26:08,530 +companies similar to them لأ و في أكتر من هيك + +346 +00:26:08,530 --> 00:26:10,930 +عندهم financial institutions كتير developed أكتر + +347 +00:26:10,930 --> 00:26:14,110 +مننا يعني أعطيكوا مثال من الشغلات أنا اقترحتها + +348 +00:26:14,110 --> 00:26:17,450 +يعني على يعني على الحكومة اللي هانو يعني المؤسسات + +349 +00:26:17,450 --> 00:26:21,830 +بتعرفوا ال ال orphanages اللي هو الأيتام اللي هانو + +350 +00:26:23,010 --> 00:26:25,770 +و ال .. some mental ill people يعني و حتى الناس + +351 +00:26:25,770 --> 00:26:28,050 +المتخرفين شويه عقليا، فإيه إيش اللي بيصير معاهم؟ + +352 +00:26:28,050 --> 00:26:31,870 +هدول أكيد في إلهم inherit، فيلهم ورثات، يعني + +353 +00:26:31,870 --> 00:26:34,790 +بيورثوا شغلات من .. من أبوه، من أمه، من .. يعني + +354 +00:26:34,790 --> 00:26:37,470 +الأخر في عنده ورثة، فإيه إيش اللي بيصير معاهم؟ + +355 +00:26:37,470 --> 00:26:41,990 +بيصير معاهم إنه ممكن إذا أخوه الكبير أو أخته أو أي + +356 +00:26:41,990 --> 00:26:47,060 +حد بتاخدها لل inheritage كله و مابيعطوهاش بصرف الولد + +357 +00:26:47,060 --> 00:26:50,680 +في الشارع أو البنت يعني مالهاش حد اللي .. او يعني + +358 +00:26:50,680 --> 00:26:53,220 +ب .. يعني بتعرفوا احنا مجتمعات شرقية و إيش اللي + +359 +00:26:53,220 --> 00:26:58,680 +بيصير بتعرفوا أكتر منهم ففي مؤسسات متخصصة لهدو + +360 +00:26:58,680 --> 00:27:01,640 +الأشياء فأي واحد من هدول الأيتام أو من ال mentally + +361 +00:27:01,640 --> 00:27:06,300 +اللي فيه إله ثروة هم هدول الناس بيجوا .. بيجوا و + +362 +00:27:06,300 --> 00:27:09,100 +بياخدوا الثروة هذه و هم بيعملوا investments + +363 +00:27:09,100 --> 00:27:13,220 +بيرجعلوا عادي اه and they are specialized in this + +364 +00:27:14,220 --> 00:27:18,760 +طبعا هذا كلام by law يعني المحكمة لازم تقرر أنه + +365 +00:27:18,760 --> 00:27:22,700 +لازم احنا نعمل هيك لإن .. لأنه بتعرفوا .. نزاعات + +366 +00:27:22,700 --> 00:27:25,880 +.. كتير في بيصير نزاعات اه ولا ناس keen و كذا و + +367 +00:27:25,880 --> 00:27:30,990 +بضحكوا عليه و يلا فاهمتوا كيف أو إذا كانت متزوجة + +368 +00:27:30,990 --> 00:27:35,670 +تكون تحت سيطرة الزوج وإذا كان مثلا هو ولا هي وحدان + +369 +00:27:35,670 --> 00:27:39,030 +يمكن أن تكون تحت سيطرة الناس الأقوية it is unfair + +370 +00:27:39,030 --> 00:27:42,910 +فبصير هذا المؤسسة ال financial institutions is in + +371 +00:27:42,910 --> 00:27:47,150 +charge in helping this guy on how to invest their + +372 +00:27:47,150 --> 00:27:53,790 +money فبصرفوله مصاريفه و بيحطوله واحد يعني يعمله + +373 +00:27:53,790 --> 00:27:57,070 +consultation وكذا ممكن يودّوه على مدارس على جامعات + +374 +00:27:57,070 --> 00:28:04,320 +على كذا و بيصير يعني يعني، نيح في المجتمع، هذا .. + +375 +00:28:04,320 --> 00:28:06,720 +يعني ماعرفش، هل مجتمعنا ممكن يعاني من شغلات زي + +376 +00:28:06,720 --> 00:28:11,840 +هيك؟ و لا أنا aggressive يعني؟ هو أكيد بعالي، بس + +377 +00:28:11,840 --> 00:28:15,440 +مش طريقة جميلة اللي يحب يساعد .. أه بالظبط، فهذه + +378 +00:28:15,440 --> 00:28:17,820 +ال financial institutions بتشتغل الشغل العالي، + +379 +00:28:17,820 --> 00:28:23,620 +خاصة ال mental ill كمان، تتفاجأوا يعني بعض الناس + +380 +00:28:23,620 --> 00:28:27,540 +اللي يعني .. احنا بنسميهم هان ع البركة و لا لأ؟ أه + +381 +00:28:28,310 --> 00:28:33,350 +يعني هذا بيكون له مثلا إلا يكون له ورثة معينة، + +382 +00:28:33,350 --> 00:28:36,970 +طبعا هذه المفروض الورثة تكون حقه، طب لأن هذا + +383 +00:28:36,970 --> 00:28:40,230 +الإنسان مايعرفش يديرها، فمين بيديه يديرها؟ بيديه + +384 +00:28:40,230 --> 00:28:44,490 +يديرها يا أخوك الكبير يا حد من جماعة .. بالظبط + +385 +00:28:44,490 --> 00:28:47,130 +مثلا، وبالتالي هذه ال institutions بتيجي + +386 +00:28:47,130 --> 00:28:50,070 +specialized هدول الناس ل mentally ill people + +387 +00:28:51,020 --> 00:28:54,640 +بياخدوا لهذا و بيصير هم يعملوا adopting له و هم + +388 +00:28:54,640 --> 00:28:58,160 +بيعملوله الاستثمارات أكتر من هيك سووا أكتر من هيك + +389 +00:28:58,160 --> 00:29:03,480 +صاروا يعملوا business باسمهم، شوفوا لوين، يعني أنا + +390 +00:29:03,480 --> 00:29:07,620 +شوفت business لهدول الناس، بس، يعني بتلاقي mall + +391 +00:29:07,620 --> 00:29:12,660 +ولا فندق كبير، بس investment لهدول الناس، مالهم مش + +392 +00:29:12,660 --> 00:29:16,240 +حاجة يعني، هم حاجة أكتر مننا the financial markets + +393 +00:29:16,240 --> 00:29:19,440 +place securities market هذا ال second thing in + +394 +00:29:19,440 --> 00:29:23,360 +this chapter the securities traded in the + +395 +00:29:23,360 --> 00:29:26,640 +financial markets ايش هي الأوراق المالية اللي + +396 +00:29:26,640 --> 00:29:32,320 +بتتداولها في السوق المالي وحكينا احنا we have + +397 +00:29:32,320 --> 00:29:36,580 +money market securities and we have capital market + +398 +00:29:36,580 --> 00:29:43,320 +securities ان هدول النوعين في ال securities what + +399 +00:29:43,320 --> 00:29:48,100 +it means security فى ناس بيقولوا security اللى هى + +400 +00:29:48,100 --> 00:29:51,720 +الأمن بقى security it means ham is different + +401 +00:29:51,720 --> 00:29:56,580 +security is a financial security this is the + +402 +00:29:56,580 --> 00:29:59,160 +meaning of security if you google it or if you + +403 +00:29:59,160 --> 00:30:02,900 +looking for the translation so security is the + +404 +00:30:02,900 --> 00:30:06,700 +peace or the safety things بقى security is the + +405 +00:30:06,700 --> 00:30:11,860 +financial security so security is a financial + +406 +00:30:11,860 --> 00:30:15,900 +instruments or financial claim ويمكن أن تأخذ شركة + +407 +00:30:15,900 --> 00:30:26,860 +تسمى اقتصاد او مالات اذا لدينا شركة شركة + +408 +00:30:26,860 --> 00:30:38,460 +تسمى اقتصاد او مالات او مالات شركة تسمى اقتصاد او + +409 +00:30:38,460 --> 00:30:41,020 +مالات او مالات او مالات او مالات او مالات او مالات + +410 +00:30:41,020 --> 00:30:41,600 +او مالات او مالات او مالات او مالات او مالات او + +411 +00:30:41,600 --> 00:30:42,550 +او مالات او مالات او مالات او مالات او موشركة + +412 +00:30:42,550 --> 00:30:46,090 +واحدة لتجارب الأمانات التي تم تجاربها الشركات + +413 +00:30:46,090 --> 00:30:50,050 +العامة لنا + +414 +00:30:50,050 --> 00:30:58,590 +لدينا اتجارات مختلفة تتجارب في هذه الأمانات فهذه + +415 +00:30:58,590 --> 00:31:03,670 +الأمانات تم تجاربها في أماكن أساسية أو في أماكن + +416 +00:31:03,670 --> 00:31:07,250 +ثانوية ما هو الفرق بين أماكن أساسية وثانوية؟ + +417 +00:31:11,970 --> 00:31:18,450 +Okay The first time The first time Okay You know + +418 +00:31:18,450 --> 00:31:23,490 +the process of issuing the .. how .. is it through + +419 +00:31:23,490 --> 00:31:25,130 +the financial market or through the investment + +420 +00:31:25,130 --> 00:31:25,530 +bank? + +421 +00:31:31,010 --> 00:31:39,150 +Okay, so okay, you are + +422 +00:31:39,150 --> 00:31:44,210 +right. So what is the difference between primary + +423 +00:31:44,210 --> 00:31:46,030 +and secondary? The purpose of the primary market + +424 +00:31:46,030 --> 00:31:49,250 +is to raise money for corporations, to raise money + +425 +00:31:49,250 --> 00:31:52,930 +for purposes. Okay. But for the secondary market is + +426 +00:31:52,930 --> 00:31:55,650 +to help people to transfer the ownership between + +427 +00:31:55,650 --> 00:31:57,410 +investors. Okay. + +428 +00:31:59,950 --> 00:32:09,410 +Okay. So again, أنت محق، السوق الرئيسي يتداول + +429 +00:32:09,410 --> 00:32:15,410 +الأموال المطلوبة الأولى للمرة الأولى في السوق + +430 +00:32:15,410 --> 00:32:19,630 +الرئيسي هو + +431 +00:32:19,630 --> 00:32:24,310 +الأموال المطلوبة الأولى للمرة الأولى على سبيل + +432 +00:32:24,310 --> 00:32:30,770 +المثال، إذا أردنا أن نبدأ شركة جديدة، هذا البرنامج + +433 +00:32:30,770 --> 00:32:36,200 +يسمى كـ Primary Market.بالتالي، بروسسة السوق + +434 +00:32:36,200 --> 00:32:42,380 +الأساسي، إذا كنا نريد أن نبدأ شركة جديدة مع قيمة + +435 +00:32:42,380 --> 00:32:48,180 +واحد مليون دولار على سبيل المثال، فيجب أن ندخل من + +436 +00:32:48,180 --> 00:32:53,980 +خلال شركة Investment Bank وشركة + +437 +00:32:53,980 --> 00:32:58,360 +Investment Bank تتعامل مع المستثمرين، المستثمرين + +438 +00:32:58,360 --> 00:32:59,800 +يعرفون كـ Investors + +439 +00:33:02,860 --> 00:33:09,320 +عشان 1 مليون دولار والآن المستخدمين يشترون هذا + +440 +00:33:09,320 --> 00:33:16,040 +الـ 1 مليون دولار من مجموعة الاستثمار، فهم يدفعون 1 + +441 +00:33:16,040 --> 00:33:21,420 +مليون دولار لمجموعة الاستثمار وبعدها مجموعة + +442 +00:33:21,420 --> 00:33:27,080 +الاستثمار تدفعها إلى الشركة، المستخدم... + +443 +00:33:27,080 --> 00:33:32,720 +ليس مجموعة الاستثمار، المستخدم، الشخصيات هنا تعتبرها + +444 +00:33:32,720 --> 00:33:40,440 +مستخدمين كمستخدمين كمستخدمين، فالمستخدمين يستخدمون + +445 +00:33:40,440 --> 00:33:44,120 +الشركة في المرة الأولى من خلال مجموعة الاستثمار، + +446 +00:33:44,120 --> 00:33:51,440 +حسنًا؟ فمجموعة الاستثمار تتعامل مع شركات على حسب + +447 +00:33:51,440 --> 00:33:57,790 +هذه الشركة، حسنًا؟ هذا في السوق الأساسي، وهذا يعني + +448 +00:33:57,790 --> 00:34:03,890 +عملية إنتاج أسهم جديدة لشركة جديدة، يعني عملية + +449 +00:34:03,890 --> 00:34:08,470 +production for new shares، يعني إنتاج أسهم جديدة + +450 +00:34:08,470 --> 00:34:17,090 +for a new company، بعد 2-3 سنة وبعد أن هذه الشركة + +451 +00:34:17,090 --> 00:34:23,450 +تحقق مصادر السوق الماليين، فهذه الشركة تذهب إلى + +452 +00:34:25,380 --> 00:34:31,280 +Secondary Market بعد + +453 +00:34:31,280 --> 00:34:38,680 +2 أو 3 سنة باعتبار حالة الماركت المالية، ويعني أن + +454 +00:34:38,680 --> 00:34:44,020 +الـ Secondary Market هي الأوراق المالية التي تم شرحها قبلها في + +455 +00:34:44,020 --> 00:34:49,900 +الـ Primary Market، فلا شركة تستطيع الذهاب إلى + +456 +00:34:49,900 --> 00:34:55,580 +الـ Secondary Market إلا بعد أن تشهد في السوق الأساسي، وكان يبقى على + +457 +00:34:55,580 --> 00:35:02,100 +الأقل لـ 2 أو 3 سنة لتحقق حالة صحية، هذه الشركة بعد + +458 +00:35:02,100 --> 00:35:07,440 +ذلك إذا كانت بخير وكانت مليئة بالوضع، فهو يذهب إلى + +459 +00:35:07,440 --> 00:35:13,900 +السوق الثانوي، فهذه هي فكرة السوق الأساسي والثانوي. + +460 +00:35:13,900 --> 00:35:18,000 +إذا + +461 +00:35:18,000 --> 00:35:19,140 +تنظر إلى الشارتات + +462 +00:35:28,020 --> 00:35:35,480 +انظروا إلى الشارت في هذه الشاشة في هذه الشاشة + +463 +00:35:35,480 --> 00:35:42,520 +تشاهد الـ Step one التي هنا هي السوق الرئيسي، لذلك + +464 +00:35:42,520 --> 00:35:47,380 +الـ Security step one يتخلصون من المال كما شرحنا + +465 +00:35:47,380 --> 00:35:52,440 +لك، لذلك الشركات تستخدم الـ Security من خلال + +466 +00:35:52,440 --> 00:35:55,500 +مجموعات الاستثمار، والاستثمارات تدفع المال إلى + +467 +00:35:55,500 --> 00:35:59,800 +الشركة أو الشركات. هذه المرحلة الأولى، المرحلة + +468 +00:35:59,800 --> 00:36:04,660 +الثانية، الشركات تستثمر في تجارب تجارب تجارب تجارب + +469 +00:36:04,660 --> 00:36:06,840 +تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب + +470 +00:36:06,840 --> 00:36:07,120 +تجارب تجارب تجارب تجارب تجارب تجارب تجارب تجارب + +471 +00:36:07,120 --> 00:36:26,220 +تجارب تجارب تجارب تجارب تجارب + +472 +00:36:27,640 --> 00:36:31,240 +عندما يكون في السوق المالي، التداولات تتعامل بين + +473 +00:36:31,240 --> 00:36:37,920 +المستخدمين في السوق الثانوي، لذلك إنهم يتعاملون أو + +474 +00:36:37,920 --> 00:36:42,740 +يتعاملون بمجموعات من أنفسهم أو بين أنفسهم في السوق + +475 +00:36:42,740 --> 00:36:49,520 +الثانوي، حسنًا؟ لذلك، هذا هو الـ Process أو الفرق + +476 +00:36:49,520 --> 00:36:53,480 +بين السوق الأساسي والسوق الثانوي، هذا يجمع + +477 +00:36:53,480 --> 00:36:59,010 +الـ Process لإعطاء المال في السوق المالي. لسا... next + +478 +00:36:59,010 --> 00:37:02,310 +meeting, we'll talk about the types of securities + +479 +00:37:02,310 --> 00:37:07,070 +so in Saturday, next Saturday, this is the last + +480 +00:37:07,070 --> 00:37:11,630 +thing in chapter two, try to prepare chapter three + +481 +00:37:11,630 --> 00:37:15,070 +so we will start chapter three in Monday and + +482 +00:37:15,070 --> 00:37:19,750 +Wednesday, so Saturday we'll talk about the... we + +483 +00:37:19,750 --> 00:37:24,350 +finish chapter two and Monday and Wednesday we'll + +484 +00:37:24,350 --> 00:37:27,430 +talk about chapter three, okay. إن شاء الله أشوفكم + +485 +00:37:27,430 --> 00:37:31,130 +على خير يوم السبت و... و Happy weekend إن شاء الله diff --git a/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/L81-Eyv6sr4_raw.json 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"probability": 0.7302734375}, {"start": 253.8, "end": 254.08, "word": " عن", "probability": 0.84033203125}, {"start": 254.08, "end": 254.8, "word": " هذا،", "probability": 0.48199462890625}, {"start": 254.8, "end": 254.9, "word": " قيمة", "probability": 0.9412434895833334}, {"start": 254.9, "end": 255.48, "word": " ال", "probability": 0.56298828125}, {"start": 255.48, "end": 255.48, "word": " net", "probability": 0.56396484375}, {"start": 255.48, "end": 255.92, "word": " asset", "probability": 0.90283203125}, {"start": 255.92, "end": 257.02, "word": " تبدأ", "probability": 0.7183837890625}, {"start": 257.02, "end": 257.44, "word": " من", "probability": 0.98388671875}, {"start": 257.44, "end": 257.78, "word": " 100", "probability": 0.80322265625}, {"start": 257.78, "end": 258.22, "word": " دولار", "probability": 0.9353841145833334}, {"start": 258.22, "end": 260.42, "word": " وتهجم", "probability": 0.4219970703125}, {"start": 260.42, "end": 261.08, "word": " المستخدمين", "probability": 0.830859375}, {"start": 261.08, "end": 261.32, "word": " الصغيرين،", "probability": 0.782080078125}, {"start": 261.32, "end": 261.66, "word": " لأن", "probability": 0.90478515625}, {"start": 261.66, "end": 262.34, "word": " المستخدم", "probability": 0.9569091796875}, {"start": 262.34, "end": 262.34, "word": " الصغير", "probability": 0.8294270833333334}, {"start": 262.34, "end": 262.66, "word": " لا", "probability": 0.9130859375}, {"start": 262.66, "end": 262.72, "word": " يمكن", "probability": 0.77685546875}, {"start": 262.72, "end": 262.92, "word": " أن", "probability": 0.2493896484375}, {"start": 262.92, "end": 264.28, "word": " يشتري", "probability": 0.741455078125}], "temperature": 1.0}, {"id": 10, "seek": 27808, "start": 264.97, "end": 278.09, "text": "الـ 100 دولار مباشرة من السوق المالي، فالأموال المالية يعطيهم فرصة لتقليل المالية باستخدام الاموال المالية باستخدام الاموال المالية باستخدام الاموال المعلقة أو المعلقة من قبل", "tokens": [6027, 39184, 2319, 11778, 12610, 9640, 3714, 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غانا ويبدأوا بالاستثمار وهذه الأجهزة، الـ100 دولار، معروفة كـ Net Asset Value وهو مخصص على أساس أسعار اليومية", "tokens": [2407, 3615, 41260, 15042, 7251, 5016, 36520, 14407, 15844, 23758, 2423, 2407, 11242, 3615, 12399, 7251, 3215, 9778, 1211, 14407, 30731, 32771, 7649, 995, 4032, 1829, 44510, 10721, 14407, 20666, 995, 14851, 12984, 2304, 9640, 4032, 3224, 24192, 16247, 7435, 3224, 11622, 3660, 12399, 2423, 39184, 6879, 11778, 12610, 9640, 12399, 20449, 32887, 5172, 3660, 9122, 39184, 6188, 1018, 3854, 39352, 37037, 2407, 3714, 9778, 9381, 9381, 15844, 5551, 3794, 32277, 5551, 3794, 3615, 9640, 45595, 20498, 10632], "avg_logprob": -0.6871044032181366, "compression_ratio": 1.4659090909090908, "no_speech_prob": 0.0, "words": [{"start": 281.29, "end": 282.65, "word": "وعندما", "probability": 0.62957763671875}, {"start": 282.65, "end": 283.61, "word": " يحصلوا", "probability": 0.629791259765625}, {"start": 283.61, "end": 283.61, "word": " على", "probability": 0.55908203125}, {"start": 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Skoda .. Lamborghini .. مش تعبانين هدول الشركات .. 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--> 00:00:25,670 +بسم الله الرحمن الرحيم اليوم سوف نتكلم عن المقال 6 + +2 +00:00:25,670 --> 00:00:31,610 +مقال الوقت من المال و سنركز على المدفوعات في + +3 +00:00:31,610 --> 00:00:37,330 +المقال السابق المقال 5 نتكلم عن و نتكلم عن و نتكلم + +4 +00:00:37,330 --> 00:00:41,490 +عن مقال الوقت من المال باستخدام واحد من المدفوعات + +5 +00:00:41,490 --> 00:00:46,790 +فالمختلف هو اليوم أننا نتكلم عن المدفوعات سنركز + +6 +00:00:46,790 --> 00:00:51,010 +على المدفوعاتفي القصة الخامسة فقط لأذكركم بقية + +7 +00:00:51,010 --> 00:00:59,210 +القصة الخامسة خمسة عامة نقل واحد عقد واحد لوقت + +8 +00:00:59,210 --> 00:01:05,950 +معين، على سبيل المثال لمدة خمس سنة أو + +9 +00:01:05,950 --> 00:01:17,780 +نقل قيمة مستقبلية واحدة مرة اليومما هي قيمة + +10 +00:01:17,780 --> 00:01:21,460 +المستقبل في هذه الحالة؟ ما هي قيمة المستقبل لدفع + +11 +00:01:21,460 --> 00:01:31,560 +واحد فقط في نهاية السنة الخامسة أو نستطيع أن نتحدث + +12 +00:01:31,560 --> 00:01:35,920 +عن ما هي القيمة الحالية لدفع يأتي بعد خمس سنة + +13 +00:01:35,920 --> 00:01:37,180 +اليوم + +14 +00:01:38,950 --> 00:01:42,470 +أنا أتكلم في القصة الخامسة عن واحد من الواجبات + +15 +00:01:42,470 --> 00:01:45,710 +الواحدة إما نتكلم عن قيمة الوقت أو قيمة المستقبل + +16 +00:01:45,710 --> 00:01:50,230 +ولكن اليوم انا مركز على الانهيوتيات مايعنيه + +17 +00:01:50,230 --> 00:01:57,750 +الانهيوتيات ولماذا نستخدم الانهيوتيات انهيوتيات + +18 +00:01:57,750 --> 00:02:07,680 +تدفع أو تحصل على واجبات أو واجبات عاديةعامة او + +19 +00:02:07,680 --> 00:02:14,580 +عامة متساومة لوقت محدد انت + +20 +00:02:14,580 --> 00:02:21,200 +تحصل على او تدفع عامة عامة + +21 +00:02:21,200 --> 00:02:25,280 +متساومة لوقت محدد على سبيل المثال إذا كنت تنظر إلى + +22 +00:02:25,280 --> 00:02:30,220 +هذا الوقت نحن + +23 +00:02:30,220 --> 00:02:38,580 +لدينا 1,2,3,4,5,6 سنةوإذا أحصلت على ألف دولار في + +24 +00:02:38,580 --> 00:02:46,060 +كل عام، فهذا يسمى بـ annuities هذا يسمى بـ + +25 +00:02:46,060 --> 00:02:50,540 +annuities إذا أحصلت على ألف دولار في كل عام، فهذا + +26 +00:02:50,540 --> 00:02:50,820 +عام، فهذا يسمى بـ annuities إذا أحصلت على ألف + +27 +00:02:50,820 --> 00:02:51,680 +على ألف دولار في كل عام، فهذا يسمى بـ annuities + +28 +00:02:51,680 --> 00:02:52,280 +إذا أحصلت على ألف دولار في كل عام، فهذا يسمى بـ + +29 +00:02:52,280 --> 00:02:54,560 +annuities إذا أحصلت على ألف دولار في كل عام، فهذا + +30 +00:02:54,560 --> 00:02:58,820 +يسمى بـ annuities إذا أحصلت على ألف دولار في كل + +31 +00:02:58,820 --> 00:03:05,830 +عام، فone thousand two thousand one thousand three + +32 +00:03:05,830 --> 00:03:09,650 +thousand so this is not annuity or this is not + +33 +00:03:09,650 --> 00:03:14,210 +regular annuity okay so we solve this problem out + +34 +00:03:14,210 --> 00:03:17,210 +by using different equations on different formulas + +35 +00:03:17,210 --> 00:03:23,700 +but the idea is hereالقانون هو أنك تحصل على أو أنك + +36 +00:03:23,700 --> 00:03:31,260 +تدفع دفعات في فترة قصيرة من الوقت، فهو في 6 سنة أو + +37 +00:03:31,260 --> 00:03:37,820 +10 سنة أو 15 سنة والدفعات عادية، فالسؤال هو لماذا + +38 +00:03:37,820 --> 00:03:41,200 +الناس يستخدمون القانون؟ لماذا الناس يستخدمون + +39 +00:03:41,200 --> 00:03:48,760 +القانون؟الناس تتلقى هذه الماليات لو أردت أن تشتري + +40 +00:03:48,760 --> 00:03:53,540 +منزل أو لو أردت أن شخص ما يشتري منزل وان هذا + +41 +00:03:53,540 --> 00:04:00,320 +المنزل بعد 10 سنة يكلف 50 ألف دولار، فماذا يجب + +42 +00:04:00,320 --> 00:04:03,840 +عليك أن تدفع تدفعات عادية لإنقاذ هذا المنزل؟ + +43 +00:04:06,950 --> 00:04:10,990 +مثل آخر مثلًا، أنت الآن في دراسة مدرسة وانت تريد + +44 +00:04:10,990 --> 00:04:17,010 +الذهاب إلى MBA لتدرس MBA، فماذا .. ما هي الدفعات + +45 +00:04:17,010 --> 00:04:20,070 +التي يجب أن تقوم بإنقاذها لكي تغطي دفع الدراسة + +46 +00:04:20,070 --> 00:04:24,910 +MBA؟ إذا دفع الدراسة MBA دفع دفع دفع دفع دفع دفع + +47 +00:04:24,910 --> 00:04:25,370 +دفع دفع دفع دفع دفع دفع دفع دفع دفع دفع دفع دفع + +48 +00:04:25,370 --> 00:04:25,670 +دفع دفع دفع دفع دفع دفع دفع دفع دفع دفع دفع دفع + +49 +00:04:25,670 --> 00:04:33,670 +دفع دف + +50 +00:04:38,130 --> 00:04:46,850 +بنكات يستخدمون مفروضات لتحرير المستخدمين لو أعطوا + +51 +00:04:46,850 --> 00:04:50,350 +مستخدمين مستخدمين لتحرير المستخدمين فكيف سيكون + +52 +00:04:50,350 --> 00:04:54,790 +المستخدمين يدفعون المستخدمين لتحرير المستخدمين لو + +53 +00:04:54,790 --> 00:05:01,790 +.. دعنا نقول إن المستخدم 100000$ فكيف سيكون + +54 +00:05:01,790 --> 00:05:08,060 +المستخدمين يدفعونالعامة العامة لإعادة 100 ألف + +55 +00:05:08,060 --> 00:05:11,740 +دولار على سبيل المثال يمكنهم أن يدفعوا 1000 دولار + +56 +00:05:11,740 --> 00:05:20,220 +لفترة قصيرة أو 500 دولار لكل عام لإعادة 100 ألف + +57 +00:05:20,220 --> 00:05:26,120 +دولار هذه هي المفروضات ومفروضات المفروضات + +58 +00:05:38,650 --> 00:05:43,330 +learning objectives of this chapter annuities, we + +59 +00:05:43,330 --> 00:05:45,050 +should know different types of annuities, + +60 +00:05:46,330 --> 00:05:49,790 +perpetuities, the difference between annuity and + +61 +00:05:49,790 --> 00:05:52,130 +perpetuity, you know the difference between + +62 +00:05:52,130 --> 00:05:56,990 +annuity and perpetuity? annuity as we explained + +63 +00:05:56,990 --> 00:06:02,980 +before it has limited period of timefor instance + +64 +00:06:02,980 --> 00:06:08,000 +you have six years, ten years and so on but for + +65 +00:06:08,000 --> 00:06:13,740 +perpetuity for unlimited period of time we invest + +66 +00:06:13,740 --> 00:06:20,660 +in a particular investment for infinity okay for + +67 +00:06:20,660 --> 00:06:24,060 +instance you are investing الوقف الاستثمار فيه + +68 +00:06:24,060 --> 00:06:29,060 +الوقف مثلا في building نحط فيه استثمار لما لنهائي + +69 +00:06:29,730 --> 00:06:32,830 +يعني كأن واحد شارع عمارة and he or she doesn't + +70 +00:06:32,830 --> 00:06:40,630 +think to sell this so it is perpetuity so + +71 +00:06:40,630 --> 00:06:42,810 +this is the difference between the perpetuities + +72 +00:06:42,810 --> 00:06:46,970 +and annuities so perpetuity is unlimited period of + +73 +00:06:46,970 --> 00:06:50,530 +time or unlimited payments فهي we have limited + +74 +00:06:50,530 --> 00:06:54,190 +payments number three complex cash flow streams + +75 +00:06:54,190 --> 00:06:58,010 +complex cash flow stream it doesn't follow the + +76 +00:06:58,010 --> 00:07:03,450 +annuityas as I said you receive one thousand + +77 +00:07:03,450 --> 00:07:05,630 +dollar in the first year and one thousand five + +78 +00:07:05,630 --> 00:07:09,750 +hundred in the second and so on so this is not + +79 +00:07:09,750 --> 00:07:13,330 +follow the the regular payments + +80 +00:07:15,420 --> 00:07:20,360 +لذلك قبل أن تحرر المشاكل يجب أن تفكر إذا كانت هذه + +81 +00:07:20,360 --> 00:07:22,840 +مجالية أو مستمرية أو مجاليات عمليات عمليات عمليات + +82 +00:07:22,840 --> 00:07:24,940 +عمليات عمليات عمليات عمليات عمليات عمليات عمليات + +83 +00:07:24,940 --> 00:07:28,840 +عمليات + +84 +00:07:28,840 --> 00:07:29,720 +عمليات عمليات عمليات عمليات عمليات عمليات عمليات + +85 +00:07:29,720 --> 00:07:32,960 +عمليات عمليات عمليات عمليات عمليات عمليات عمليات + +86 +00:07:32,960 --> 00:07:43,000 +عمليات عمليات عمليات عمليات عمليات عمليات عملي + +87 +00:07:43,450 --> 00:07:48,390 +مختلف بين عامة الانهيوتي وانهيوتي قادمة فما هو + +88 +00:07:48,390 --> 00:07:55,350 +الفرق بينهم؟ تأخذ هذا المثال هنا واحد اثنين اثنين + +89 +00:07:55,350 --> 00:07:58,230 +اثنين اثنين وخمس وخمس وخمس وخمس وخمس وخمس وخمس + +90 +00:07:58,230 --> 00:08:08,230 +وخمس وخمس وخمس وخمس وخمس وخمس وخمس وخمس وخمس + +91 +00:08:08,230 --> 00:08:08,430 +وخمس وخمس وخمس وخمس وخمس وخمس وخمس وخمس وخمس وخمس + +92 +00:08:08,430 --> 00:08:13,120 +وخمس وخمس وخمس وخمس وخمس وخat the beginning of the + +93 +00:08:13,120 --> 00:08:16,560 +year or at the end of the year if the payment + +94 +00:08:16,560 --> 00:08:20,360 +coming at the end of the year is in here so it is + +95 +00:08:20,360 --> 00:08:27,420 +known as ordinary ordinary payments if + +96 +00:08:27,420 --> 00:08:33,060 +it's coming here if it's coming here and so on but + +97 +00:08:33,060 --> 00:08:37,220 +if the payment coming at the beginning it's here + +98 +00:08:37,220 --> 00:08:44,130 +so it is dueالان من نظر المعرفة أو من نظر + +99 +00:08:44,130 --> 00:08:49,450 +الاستثمار ماهي الفرق بين ordinary و due هناك فرق + +100 +00:08:49,450 --> 00:08:54,690 +كبير بينهم لأن في ال due نحن لدينا أكتر مكان + +101 +00:08:54,690 --> 00:08:59,090 +لإستثمار مالنا ولكن في ال ordinary نحن لدينا أقل + +102 +00:08:59,090 --> 00:09:02,170 +مكان أو أقل غرفة لإستثمار مالنا تأكد من هذا المثال + +103 +00:09:02,170 --> 00:09:09,170 +على + +104 +00:09:09,170 --> 00:09:09,910 +سبيل المثال هنا + +105 +00:09:13,600 --> 00:09:24,140 +انت تدفع ألف دولار كل عام لخمس + +106 +00:09:24,140 --> 00:09:29,700 +سنة تعتبر + +107 +00:09:29,700 --> 00:09:41,380 +الحالة عادية وحالة أخرى قدرة تشاهد الفرق الأن حسنا + +108 +00:09:44,820 --> 00:09:56,920 +1,2,3,4,5 لذا لدينا ألف هنا و 1,2,3,4,5 لذا لدينا + +109 +00:09:56,920 --> 00:10:04,560 +ألف ألف ألف ألف ألف ألف و ألف ألف و ألف ألف حسنًا + +110 +00:10:04,560 --> 00:10:10,940 +إذا كنا نعتقد أن هذا عادى هذا عادى فالدفع يأتي من + +111 +00:10:10,940 --> 00:10:16,280 +هناأذا كم ساعة تستخدم لتستخدم هذا هو أول 1000$ + +112 +00:10:16,280 --> 00:10:22,860 +لخمس سنة حسنا نستخدم المعلومات + +113 +00:10:22,860 --> 00:10:28,480 +الخاصة بنا من القصة الخامسة فهذا 1000$ استخدم حتى + +114 +00:10:28,480 --> 00:10:33,720 +خمس سنة كم ساعة تستخدم؟ واحد اثنى اثنى اثنى اربع + +115 +00:10:33,720 --> 00:10:36,420 +اربع اربع اربع اربع اربع اربع اربع اربع اربع اربع + +116 +00:10:36,420 --> 00:10:36,460 +اربع اربع اربع اربع اربع اربع اربع اربع اربع اربع + +117 +00:10:36,460 --> 00:10:36,820 +اربع اربع اربع اربع اربع اربع اربع اربع اربع اربع + +118 +00:10:36,820 --> 00:10:37,240 +اربع اربع اربع اربع اربع اربع اربع اربع اربع اربع + +119 +00:10:37,240 --> 00:10:40,400 +اربع اربع + +120 +00:10:40,400 --> 00:10:48,120 +اربI هي المهتمة ، لذلك الـ N هنا هو 4 سنة لأن 1,2 + +121 +00:10:48,120 --> 00:10:52,680 +,3,4 وانت + +122 +00:10:52,680 --> 00:10:57,060 +تفعل نفس الشيء ، قيمة المستقبل 1 plus I بقية 3 + +123 +00:10:57,060 --> 00:11:04,080 +وهنا قيمة المستقبل 1 plus I بقية 2 وهنا قيمة + +124 +00:11:04,080 --> 00:11:08,800 +المستقبل 1 plus I بقية 1 وهنا قيمة المستقبل هي + +125 +00:11:08,800 --> 00:11:17,960 +قيمة الحالةبسبب 1 plus I بقية 0 وهو 1 فقط + +126 +00:11:17,960 --> 00:11:25,340 +تصور هذه الحالة وانظر .. وانظر + +127 +00:11:25,340 --> 00:11:31,440 +ال .. إذا كان هذا عادى، انظر إنه قدر، إذا كان قدر، + +128 +00:11:31,440 --> 00:11:40,310 +اخذ نفس الاتصالOkay starting by one two three four + +129 +00:11:40,310 --> 00:11:48,150 +five so here is zero one two three four five we + +130 +00:11:48,150 --> 00:11:50,570 +starting from here + +131 +00:11:53,480 --> 00:11:58,780 +ولدينا ألف واحد و ألف واحد و ألف واحد و ألف واحد و + +132 +00:11:58,780 --> 00:12:01,100 +ألف واحد و ألف واحد و ألف واحد و ألف واحد و ألف + +133 +00:12:01,100 --> 00:12:01,120 +واحد و ألف واحد و ألف واحد و ألف واحد و ألف واحد و + +134 +00:12:01,120 --> 00:12:01,360 +ألف واحد و ألف واحد و ألف واحد و ألف واحد و ألف + +135 +00:12:01,360 --> 00:12:01,440 +واحد و ألف واحد و ألف واحد و ألف واحد و ألف واحد و + +136 +00:12:01,440 --> 00:12:01,460 +ألف واحد و ألف واحد و ألف واحد و ألف واحد و ألف + +137 +00:12:01,460 --> 00:12:02,860 +واحد و ألف واحد و ألف واحد و ألف واحد و ألف واحد و + +138 +00:12:02,860 --> 00:12:03,460 +ألف واحد و ألف واحد و ألف واحد و ألف واحد و ألف + +139 +00:12:03,460 --> 00:12:03,980 +واحد و ألف واحد و ألف واحد و ألف واحد و ألف واحد و + +140 +00:12:03,980 --> 00:12:08,040 +ألف واحد و ألف واحد و ألف واحد و + +141 +00:12:08,040 --> 00:12:16,820 +ألف واحد و + +142 +00:12:16,820 --> 00:12:21,010 +أولكن في هذه الحالة هنا فقط لدينا 4 عامة إذا كنت + +143 +00:12:21,010 --> 00:12:25,730 +تقارن بين هذه الأسلحة والهذه الأسلحة أو هذه + +144 +00:12:25,730 --> 00:12:28,370 +الأسلحة المالية والهذه الأسلحة المالية الأسلحة + +145 +00:12:28,370 --> 00:12:32,650 +المالية لذلك هنا فإنها أعلى للقوة 4 ولكن هنا فإنها + +146 +00:12:32,650 --> 00:12:38,650 +أعلى للقوة 5 اذهب للأسلحة الثانية فهي قيمة + +147 +00:12:38,650 --> 00:12:45,370 +المستقبل 1 plus I 1234أخذ الثالث قيمة مستقبلية + +148 +00:12:45,370 --> 00:12:47,490 +واحدة اكتر من اكتر من اكتر من اكتر من اكتر من اكتر + +149 +00:12:47,490 --> 00:12:47,830 +من اكتر من اكتر من اكتر من اكتر من اكتر من اكتر من + +150 +00:12:47,830 --> 00:12:50,350 +اكتر من اكتر من اكتر من اكتر من اكتر من اكتر من + +151 +00:12:50,350 --> 00:12:56,270 +اكتر من اكتر من اكتر من اكتر من اكتر من اكتر من + +152 +00:12:56,270 --> 00:12:56,410 +اكتر من اكتر من اكتر من اكتر من اكتر من اكتر من + +153 +00:12:56,410 --> 00:12:58,230 +اكتر من اكتر من اكتر من اكتر من اكتر من اكتر من + +154 +00:12:58,230 --> 00:13:02,730 +اكتر من اكتر من اكتر من اكتر من اكتر من ا + +155 +00:13:07,770 --> 00:13:11,850 +In the beginning of the fifth year, we have one + +156 +00:13:11,850 --> 00:13:15,410 +year to invest, so future value one plus I and one + +157 +00:13:15,410 --> 00:13:19,090 +year So we have more room or we have more space to + +158 +00:13:19,090 --> 00:13:25,330 +invest our cash flows So this is ordinary and this + +159 +00:13:25,330 --> 00:13:29,130 +is due Any question related to this? + +160 +00:13:39,190 --> 00:13:44,830 +للفورمولة الفورمولة هنا وانت تلاحظ اننا نستخدم + +161 +00:13:44,830 --> 00:13:52,750 +الفورمولة في خطة 5 نستخدمها نستخدمها نستخدمها + +162 +00:13:52,750 --> 00:13:53,490 +نستخدمها نستخدمها نستخدمها نستخدمها نستخدمها + +163 +00:13:53,490 --> 00:13:54,130 +نستخدمها نستخدمها نستخدمها نستخدمها نستخدمها + +164 +00:13:54,130 --> 00:13:57,590 +نستخدمها نستخدمها نستخدمها نستخدمها نستخدمها + +165 +00:13:57,590 --> 00:13:58,210 +نستخدمها نستخدمها نستخدمها نستخدمها نستخدمها + +166 +00:13:58,210 --> 00:13:58,590 +نستخدمها نستخدمها نستخدمها نستخدمها نستخدمها + +167 +00:13:58,590 --> 00:14:03,350 +نستخدمها نستخدمها نستخدمها نستخدمها نستخ + +168 +00:14:06,790 --> 00:14:16,670 +الدفعات هذه الدفعات لأنها عامة واحدة أكتر I باور N + +169 +00:14:16,670 --> 00:14:26,210 +مختلفة من I أقل واحدة لذلك هذه هي الفورمولة هذا هو + +170 +00:14:26,210 --> 00:14:33,870 +الفورمولة لهذا وما هي الفرصة بينها فقط + +171 +00:14:33,870 --> 00:14:40,890 +يضيف واحدة أكترI to this formula okay so we will + +172 +00:14:40,890 --> 00:14:46,330 +see + +173 +00:14:46,330 --> 00:15:03,230 +okay + +174 +00:15:04,530 --> 00:15:10,090 +فنحن نعرف الفرق بين عادية عيوبة وعيوبة قدرة ونحن + +175 +00:15:10,090 --> 00:15:13,850 +نتكلم + +176 +00:15:13,850 --> 00:15:19,070 +الآن فقط عن عيوبة المستقبل عيوبة المستقبل إذا أحنا + +177 +00:15:19,070 --> 00:15:24,970 +نحصل على عيوبة في المستقبل ما هي عيوبة ما هي عيوبة + +178 +00:15:24,970 --> 00:15:30,450 +المستقبل اليوم إذا عيوبة هذا إذا كنا ندفع عيوبة + +179 +00:15:30,450 --> 00:15:30,850 +عادية + +180 +00:15:35,550 --> 00:15:40,470 +الثاني يتخيل قيمة الحصول على مستمر مستمر ومستمر + +181 +00:15:40,470 --> 00:15:43,250 +مستمر مستمر مستمر مستمر مستمر مستمر مستمر مستمر + +182 +00:15:43,250 --> 00:15:43,410 +مستمر مستمر مستمر مستمر مستمر مستمر مستمر مستمر + +183 +00:15:43,410 --> 00:15:44,270 +مستمر مستمر مستمر مستمر مستمر مستمر مستمر مستمر + +184 +00:15:44,270 --> 00:15:48,550 +مستر مستر مستر مستر مستر مستر مستر مستر مستر مستر + +185 +00:15:48,550 --> 00:15:49,090 +مستر مستر مستر مستر مستر مستر مستر مستر مستر مستر + +186 +00:15:49,090 --> 00:15:49,170 +مستر مستر مستر مستر مستر مستر مستر مستر مستر مستر + +187 +00:15:49,170 --> 00:15:53,030 +مستر مستر مستر مستر مستر مستر مستر مستر مستر مستر + +188 +00:15:53,030 --> 00:15:56,290 +مستر مستر م + +189 +00:15:58,970 --> 00:16:03,810 +كما أعطيكم مثلًا في الانسانية الإسلامية لدينا شيء + +190 +00:16:03,810 --> 00:16:07,750 +يسمى الوخف الوخف هذا لمرحلة غير محددة من الوقت، + +191 +00:16:07,750 --> 00:16:11,270 +لذلك إذا دفعنا للوخف هذا يعني أننا لسنا لدينا + +192 +00:16:11,270 --> 00:16:14,530 +مرحلة غير محددة من الوقت للinvestments لذلك نحصل + +193 +00:16:14,530 --> 00:16:23,050 +في كل عام مقدمة معينة لإنفانية وإذا هذا يتزام لرقم + +194 +00:16:23,050 --> 00:16:25,530 +تزام معين لذلك سنرى كيف يمكننا أن نتعامل مع هذا + +195 +00:16:25,530 --> 00:16:31,170 +المشكلةفي التعامل التقليدي، لدينا شيء معروف بـ + +196 +00:16:31,170 --> 00:16:36,690 +Perpetuity Bonds Perpetuity Bonds يدفع الهدايا + +197 +00:16:36,690 --> 00:16:44,390 +لمرات غير محدودة، للمحافظين على المعاملات، لذلك + +198 +00:16:44,390 --> 00:16:49,710 +لديها عاملات عامة في الحياة الحقيقيةعن هذا الموضوع + +199 +00:16:49,710 --> 00:16:53,350 +رقم ثلاثة تخطيط قيمة الحاضر والحاضر ومستقبل قيمة + +200 +00:16:53,350 --> 00:16:56,210 +مجموعات تجارب تجارب المال إذا كان لدينا تجارب غير + +201 +00:16:56,210 --> 00:17:00,950 +عامة كيف نستطيع أن نتعامل معها؟ الرقم يتضمن في هذه + +202 +00:17:00,950 --> 00:17:04,430 +القصة وقد تحدثنا عنها في القصة واحدة المال لديه + +203 +00:17:04,430 --> 00:17:12,330 +قيمة ومستقبل مصادر قيمة وفي مجلسك أسئلتك عن الفرق + +204 +00:17:12,330 --> 00:17:14,010 +بين إعادة المصادر و + +205 +00:17:16,140 --> 00:17:19,140 +والاستخدام الوزارة الوزارة الاستخدام الوزارة + +206 +00:17:19,140 --> 00:17:22,280 +الاستخدام هي تأثيرها من المال الواقعي من المال + +207 +00:17:22,280 --> 00:17:25,960 +الواقعي لأن المستخدمين ينظروا إلى مجموعات المال + +208 +00:17:25,960 --> 00:17:29,420 +والمال والمال والمال والمال والمال والمال والمال + +209 +00:17:29,420 --> 00:17:29,580 +والمال والمال والمال والمال والمال والمال والمال + +210 +00:17:29,580 --> 00:17:31,260 +والمال والمال والمال والمال والمال والمال والمال + +211 +00:17:31,260 --> 00:17:31,760 +والمال والمال والمال والمال والمال والمال والمال + +212 +00:17:31,760 --> 00:17:32,160 +والمال والمال والمال والمال والمال والمال والمال + +213 +00:17:32,160 --> 00:17:32,840 +والمال والمال والمال والمال والمال والمال والمال + +214 +00:17:32,840 --> 00:17:34,920 +والمال + +215 +00:17:38,750 --> 00:17:41,870 +Annuity is a series of equal dollar payments, + +216 +00:17:42,170 --> 00:17:45,330 +regular payments that are made at the end of + +217 +00:17:45,330 --> 00:17:48,430 +equidistant points in time such as monthly, + +218 +00:17:48,650 --> 00:17:52,950 +quarterly, annually or over a finite period of + +219 +00:17:52,950 --> 00:17:57,050 +time If payments are made at the end of each + +220 +00:17:57,050 --> 00:18:00,030 +period, the annuity is referred to as ordinary + +221 +00:18:00,030 --> 00:18:01,610 +annuity + +222 +00:18:04,000 --> 00:18:08,200 +See this example here, how much money will you + +223 +00:18:08,200 --> 00:18:12,240 +accumulate by the end of year 10? So when you are + +224 +00:18:12,240 --> 00:18:14,520 +answering .. when you are answering or handling + +225 +00:18:14,520 --> 00:18:18,800 +the question to be a professional I think it's + +226 +00:18:18,800 --> 00:18:22,880 +fine to .. to have this margin space here and to + +227 +00:18:22,880 --> 00:18:25,100 +write the information that's coming from the + +228 +00:18:25,100 --> 00:18:29,530 +questionit's important and try to think what is + +229 +00:18:29,530 --> 00:18:32,850 +the examiners will ask you this is a good approach + +230 +00:18:32,850 --> 00:18:38,010 +just to try to guess how much money will you + +231 +00:18:38,010 --> 00:18:42,670 +accumulate by the end of year 10 so we have n is + +232 +00:18:42,670 --> 00:18:48,990 +equal 10 just do like in this way if at the end of + +233 +00:18:48,990 --> 00:18:52,990 +year 10 if you deposit three thousand dollar is + +234 +00:18:52,990 --> 00:18:57,140 +this future value or this is paymentThis is + +235 +00:18:57,140 --> 00:18:59,900 +present value or payment so this is the payment + +236 +00:18:59,900 --> 00:19:04,240 +the payments and this is annual payments and + +237 +00:19:04,240 --> 00:19:09,510 +regular paymentsلأن في محافظتك .. دعنا نرى في + +238 +00:19:09,510 --> 00:19:14,070 +محافظتك الأخيرة محافظتك ليست حالة لك هل هذا عرض + +239 +00:19:14,070 --> 00:19:18,210 +عادل، هل هذا عرض عطالة أو هذا ليس عطالة، هل هذا + +240 +00:19:18,210 --> 00:19:23,410 +كاشف كمplex؟ لا، هذا ليس .. ليس بقى بسيط كما تفكر + +241 +00:19:23,410 --> 00:19:30,750 +حاول أن تجهز عقلك، تفكر كيف تتعامل مع السؤال، لذا + +242 +00:19:30,750 --> 00:19:37,930 +عرضها 3000 دولاركل عام ل10 سنة لذا لدينا 10 سنة في + +243 +00:19:37,930 --> 00:19:47,150 +محافظة تقريبا 5% لذا I هو 5% في محافظة تقريبا 5% + +244 +00:19:47,150 --> 00:19:51,510 +لذا كم سيكومل المال عندما تعرف ماذا يعني اكومليت + +245 +00:19:51,510 --> 00:19:56,590 +اكومليت يعني المستقبل ماهي قيمة المستقبل لذا نحتاج + +246 +00:19:56,590 --> 00:20:02,990 +قيمة المستقبلماهي قيمة المستقبل؟ أولا قبل أن أسأل + +247 +00:20:02,990 --> 00:20:08,510 +أو أجاب هذا السؤال أريد فقط أن أدخل عقلك إلى هذا + +248 +00:20:08,510 --> 00:20:14,110 +الشيء في + +249 +00:20:14,110 --> 00:20:17,690 +السؤالين لدينا اختيارات، الكثير من الأختيارات. + +250 +00:20:18,070 --> 00:20:24,150 +يمكنني أن أعطيك الـ N أو المساعدة و I سأسألك عن + +251 +00:20:24,150 --> 00:20:31,370 +قيمة المستقبلor I may give you N payments and ask + +252 +00:20:31,370 --> 00:20:39,370 +you about the I or I may give you N and I'm asking + +253 +00:20:39,370 --> 00:20:45,370 +you about the payment or the last case is I'm + +254 +00:20:45,370 --> 00:20:48,590 +asking you about what are they what how long it + +255 +00:20:48,590 --> 00:20:53,530 +takes to invest a particular amount of money at a + +256 +00:20:53,530 --> 00:20:59,560 +particular interest rateوالقيم المستقبلية X هذه هي + +257 +00:20:59,560 --> 00:21:04,300 +الاختيارات للسؤالين يمكنني أن أطلب منك ان تعطلي + +258 +00:21:04,300 --> 00:21:07,740 +قيم المستقبلية او ماهي قيم المستقبلية او ماهي + +259 +00:21:07,740 --> 00:21:11,060 +المساعدة او ماهي المساعدة الأخرى او ماهي عدد + +260 +00:21:11,060 --> 00:21:17,240 +الوقتات تعتبر هذه الحالة حسنا؟ + +261 +00:21:17,240 --> 00:21:21,080 +في هذه الحالة نحن نسأل عن قيم المستقبلية + +262 +00:21:21,080 --> 00:21:28,320 +فالفورميلة هيالقيم المستقبلية، وانتباه، هذه هي + +263 +00:21:28,320 --> 00:21:32,520 +مفروضة مفروضة مستقبلية مستقبلية مستقبلية مستقبلية + +264 +00:21:32,520 --> 00:21:33,880 +مستقبلية مستقبلية مستقبلية مستقبلية مستقبلية + +265 +00:21:33,880 --> 00:21:35,760 +مستقبلية مستقبلية مستقبلية مستقبلية مستقبلية + +266 +00:21:35,760 --> 00:21:36,900 +مستقبلية مستقبلية مستقبلية مستقبلية مستقبلية + +267 +00:21:36,900 --> 00:21:38,260 +مستقبلية مستقبلية مستقبلية مستقبلية مستقبلية + +268 +00:21:38,260 --> 00:21:38,620 +مستقبلية مستقبلية مستقبلية مستقبلية مستقبلية + +269 +00:21:38,620 --> 00:21:43,820 +مستقبلية مستقبلية مستقبلية مستقبلية + +270 +00:21:43,820 --> 00:21:50,460 +مستقبلية مست + +271 +00:21:52,050 --> 00:21:58,950 +One plus I, I is five percent, so O five raised to + +272 +00:21:58,950 --> 00:22:07,590 +the power ten minus one divided by point O five So + +273 +00:22:07,590 --> 00:22:10,950 +the future value is, let's see the answer in here + +274 +00:22:10,950 --> 00:22:14,230 +As you see this is the + +275 +00:22:19,290 --> 00:22:29,030 +وهو 37000$ 740$ إذا كان لديك كالكولاتور المالي، + +276 +00:22:29,030 --> 00:22:33,310 +يمكنك استخدام الـ N و In this way أو باستخدام + +277 +00:22:33,310 --> 00:22:38,270 +Excel، باستخدام قيمة المستقبل، باستخدام قيمة البيع + +278 +00:22:38,270 --> 00:22:38,730 +و البيع + +279 +00:22:47,140 --> 00:22:51,220 +how much money will you accumulate by the end of + +280 +00:22:51,220 --> 00:22:57,360 +year 10 if you deposit each for the next 10 years + +281 +00:22:57,360 --> 00:22:59,860 +in a saving account that earns 5% + +282 +00:23:04,080 --> 00:23:06,160 +سحب الحفاظ على الحفاظ على الحفاظ على الحفاظ على + +283 +00:23:06,160 --> 00:23:10,960 +الحفاظ على الحفاظ على الحفاظ على الحفاظ على الحفاظ + +284 +00:23:10,960 --> 00:23:13,000 +على الحفاظ على الحفاظ على الحفاظ على الحفاظ على + +285 +00:23:13,000 --> 00:23:13,760 +الحفاظ على الحفاظ على الحفاظ على الحفاظ على الحفاظ + +286 +00:23:13,760 --> 00:23:15,500 +على الحفاظ على الحفاظ على الحفاص على الحفاص على + +287 +00:23:15,500 --> 00:23:17,300 +الحفاص على الحفاص على الحفاص على الحفاص على الحفاص + +288 +00:23:17,300 --> 00:23:26,380 +الحفاص على الحفاص على الحفاص على الحفاص على الحفاص + +289 +00:23:26,380 --> 00:23:31,360 +على الحفاص على الحفاص على الحفاص علىالأولى لذلك + +290 +00:23:31,360 --> 00:23:35,320 +عندما نستخدم at the end هذا يعني أننا نستخدم عادية + +291 +00:23:35,320 --> 00:23:38,460 +عادية + +292 +00:23:38,460 --> 00:23:44,500 +في هذه الحالة نعرف القيم من I وقيم المستقبل في + +293 +00:23:44,500 --> 00:23:50,460 +المقارنة ونحتاج لنقرر قيم الدفع اختيار هذا المثال + +294 +00:23:50,460 --> 00:23:56,940 +هنا مثال 6.2 اعترض أنك ترغب أن تكون لديك 2500 + +295 +00:23:59,440 --> 00:24:09,020 +قبل 6 سنة لتدفع تجاربك على بيت جديد لتدفع + +296 +00:24:09,020 --> 00:24:24,280 +تجاربك + +297 +00:24:24,280 --> 00:24:25,020 +على بيت جديد + +298 +00:24:28,040 --> 00:24:31,360 +I gave my student last year question looks like + +299 +00:24:31,360 --> 00:24:34,980 +this but the problem is just only one or two + +300 +00:24:34,980 --> 00:24:38,780 +students answer this question what I've done is + +301 +00:24:38,780 --> 00:24:47,260 +like the house is worth + +302 +00:24:47,260 --> 00:24:54,450 +one hundred thousand dollar it is wealthولكن عندما + +303 +00:24:54,450 --> 00:25:01,470 +تكون لديك المال ستدفع 35000 للمساعدة أو للمساعدين + +304 +00:25:01,470 --> 00:25:07,690 +والبقية + +305 +00:25:07,690 --> 00:25:14,070 +ستدفعها بأخذ دفع من البنك، فماذا نستطيع فعله في + +306 +00:25:14,070 --> 00:25:18,270 +هذه الحالة؟I am deducted لخمسة و تلاتين ألف من + +307 +00:25:18,270 --> 00:25:21,690 +مائة ألف So what is the future value that you will + +308 +00:25:21,690 --> 00:25:25,330 +pay؟ خمسين و سبعين ألف Yes, no, sixty five + +309 +00:25:25,330 --> 00:25:28,630 +thousand But most of the students sought out by + +310 +00:25:28,630 --> 00:25:31,550 +taking the one hundred thousand dollar not this + +311 +00:25:31,550 --> 00:25:34,870 +because here you paid you already paid thirty five + +312 +00:25:34,870 --> 00:25:39,430 +thousand so be careful this in this case how much + +313 +00:25:39,430 --> 00:25:44,130 +you will invest in your money okay + +314 +00:25:45,820 --> 00:25:51,500 +مثلا إذا كنت ترغب أن تحصل على 25000 فالقيم + +315 +00:25:51,500 --> 00:26:02,040 +المقابلة هنا 25000 إذا كنت تقوم بإصلاح عامة عامة + +316 +00:26:02,040 --> 00:26:08,720 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +317 +00:26:08,720 --> 00:26:18,110 +عامة عامة عامة عامة عامةعامة الاستثمار 7% ونحن + +318 +00:26:18,110 --> 00:26:23,090 +نسأل عن الواجبات ونحن لا نعرف الواجبات و N هي 10 + +319 +00:26:23,090 --> 00:26:30,850 +سنة و 6 سنة نعم + +320 +00:26:30,850 --> 00:26:31,190 +نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم + +321 +00:26:31,190 --> 00:26:31,370 +نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم + +322 +00:26:31,370 --> 00:26:32,870 +نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم + +323 +00:26:32,870 --> 00:26:33,790 +نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم + +324 +00:26:33,790 --> 00:26:33,810 +نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم نعم + +325 +00:26:33,810 --> 00:26:40,490 +نعم + +326 +00:26:40,490 --> 00:26:50,010 +نعم نهذه هي الفورمولة هنا نعرف أن قيمة المستقبل + +327 +00:26:50,010 --> 00:27:03,450 +25000 لا نعرف المدفع نعرف أن 1 plus I هو 0.076-1 + +328 +00:27:03,450 --> 00:27:07,170 +مقاطع 0.07 + +329 +00:27:16,520 --> 00:27:19,280 +هل نعرف القيامة او لا نعرف القيامة؟ لذلك نسأل عن + +330 +00:27:19,280 --> 00:27:27,400 +القيامة بسيطة فقط افعل التخطيطات من هذا ثم اختلطها + +331 +00:27:27,400 --> 00:27:32,920 +على 25000 والتخطيطات من هذا ستحصل على القيامة + +332 +00:27:32,920 --> 00:27:36,320 +دعونا + +333 +00:27:36,320 --> 00:27:43,100 +نرى هنا قيمة المستقبل هذه هي المثلثة هنا 25000 لا + +334 +00:27:43,100 --> 00:27:44,040 +نعرف القيامة + +335 +00:27:46,660 --> 00:27:53,200 +هذه هي التخطيطات لهذا المجلد هذا المجلد هو 7.153 + +336 +00:27:53,200 --> 00:27:55,640 +مليون دولار فقط قمت بتحويره إلى 25000 مليون دولار + +337 +00:27:55,640 --> 00:27:57,540 +في 7.153 مليون دولار في 7.153 مليون دولار في 7.153 + +338 +00:27:57,540 --> 00:27:59,540 +مليون دولار في 7.153 مليون دولار في 7.153 مليون + +339 +00:27:59,540 --> 00:28:02,020 +دولار في 7.153 مليون دولار في 7.153 مليون دولار في + +340 +00:28:02,020 --> 00:28:02,240 +7.153 مليون دولار في 7.153 مليون دولار في 7.153 + +341 +00:28:02,240 --> 00:28:02,260 +دولار في 7.153 مليون دولار في 7.153 مليون دولار في + +342 +00:28:02,260 --> 00:28:08,240 +7.153 مليون دولار في 7.153 مليون د + +343 +00:28:20,170 --> 00:28:31,970 +Okay, double check this how + +344 +00:28:31,970 --> 00:28:38,290 +much must you deposit in a savings account earning + +345 +00:28:38,290 --> 00:28:42,850 +eight percent okay so it's I is equal eight + +346 +00:28:42,850 --> 00:28:48,950 +percent annual interest it is annual interestIn + +347 +00:28:48,950 --> 00:28:52,250 +order to accumulate 5000$ accumulate it means + +348 +00:28:52,250 --> 00:28:58,510 +future so the future value is 5000$ to accumulate + +349 +00:28:58,510 --> 00:29:03,610 +5000$ at the end of 10 years so we have n is 10 + +350 +00:29:03,610 --> 00:29:06,670 +years let's solve this problem using the + +351 +00:29:06,670 --> 00:29:09,830 +mathematical formulas so we have I we have future + +352 +00:29:09,830 --> 00:29:15,380 +value we have n what we want the paymentبشكل مشابه + +353 +00:29:15,380 --> 00:29:18,900 +للقبل لذلك قيمة المستقبل مرة أخرى قيمة المستقبل + +354 +00:29:18,900 --> 00:29:24,680 +واحد قيمة المستقبل هي اكتشاف المال مرة واحدة + +355 +00:29:24,680 --> 00:29:27,080 +اكتشاف واحدة اكتشاف واحدة اكتشاف واحد اكتشاف واحد + +356 +00:29:27,080 --> 00:29:28,480 +اكتشاف واحد اكتشاف واحد اكتشاف واحد اكتشاف واحد + +357 +00:29:28,480 --> 00:29:29,500 +اكتشاف واحد اكتشاف واحد اكتشاف واحد اكتشاف واحد + +358 +00:29:29,500 --> 00:29:29,620 +اكتشاف واحد اكتشاف واحد اكتشاف واحد اكتشاف واحد + +359 +00:29:29,620 --> 00:29:31,180 +اكتشاف واحد اكتشاف واحد اكتشاف واحد اكتشاف واحد + +360 +00:29:31,180 --> 00:29:39,220 +اكتشاف واحد اكتشاف واحد اكتشاف + +361 +00:29:39,220 --> 00:29:42,580 +واحد اكتشاف + +362 +00:29:42,580 --> 00:29:50,140 +واحد ا10 minus 1 divided by 0.08 just very simple + +363 +00:29:50,140 --> 00:30:00,640 +do the calculations here 5000 just carry on 345$ 0 + +364 +00:30:00,640 --> 00:30:10,580 +.15 okay so as you see the paymentوانت تحصل على + +365 +00:30:10,580 --> 00:30:16,240 +345$ إذا كان لديك كاركولاتور علمي أو كاركولاتور + +366 +00:30:16,240 --> 00:30:18,580 +اقتصادي هذا بسيط جدا يمكنك أن تفعله، هل هناك أحد + +367 +00:30:18,580 --> 00:30:23,860 +يستخدم كاركولاتور اقتصادي؟ لا؟ حسنا، ويمكنك + +368 +00:30:23,860 --> 00:30:25,760 +استخدام شريط إكسل أيضا + +369 +00:30:35,910 --> 00:30:41,590 +Okay so far we talked about if we don't know the + +370 +00:30:41,590 --> 00:30:46,410 +future value if we don't know N and if we don't + +371 +00:30:46,410 --> 00:30:50,570 +know the payment now the I this is much + +372 +00:30:50,570 --> 00:30:54,230 +complicated because we need to do like try and + +373 +00:30:54,230 --> 00:30:59,610 +error it's not like the in chapter 5 it's not the + +374 +00:30:59,610 --> 00:31:00,790 +same things + +375 +00:31:06,750 --> 00:31:10,410 +بإمكانك أيضًا تحلل عدد الدفع التي يجب أن تنتهي على + +376 +00:31:10,410 --> 00:31:14,630 +عملياتك التي ستسمح لك عملياتك أن تنمو إلى عدد معين + +377 +00:31:14,630 --> 00:31:22,190 +من المال بوقت مقتنع في هذه الحالة، نعرف قيم N، + +378 +00:31:22,190 --> 00:31:28,470 +نعرف الدفع، نعرف قيم المستقبل، لكننا لا نعرف I، لا + +379 +00:31:28,470 --> 00:31:35,310 +نعرف عدد الدفعأخذ هذا المثال هنا في 20 سنة تتمنى + +380 +00:31:35,310 --> 00:31:40,470 +أن تنقل 100 ألف دولار، هل هذا قيمة أو قيمة + +381 +00:31:40,470 --> 00:31:45,630 +المستقبل؟ قيمة المستقبل، نعم إنها قيمة المستقبل، + +382 +00:31:45,630 --> 00:31:49,170 +تجاه دراسة دراسة طفولتك في المدرسة الدراسية، إذا + +383 +00:31:49,170 --> 00:31:54,590 +كنت ممكن أن تنقل 2500 دولار في نهاية كل عام، فهذه + +384 +00:31:54,590 --> 00:32:00,440 +هي القيمةللعام الماضي 20 سنة هذا N ماهي عدد + +385 +00:32:00,440 --> 00:32:02,480 +الترجمة التي يجب عليك أن تقوم بها في مستخدمك + +386 +00:32:02,480 --> 00:32:07,900 +لإنهاء مهتمتك لذلك نحتاج إلى I نحتاج إلى C + +387 +00:32:07,900 --> 00:32:13,380 +باستخدام الواقعات العلمية نعرف قيمة المستقبل نعرف + +388 +00:32:13,380 --> 00:32:20,800 +المدافعين نعرف ان ال N هو 20 ومع نفس الواقع 1 plus + +389 +00:32:20,800 --> 00:32:29,230 +I مقاطع I مقاطع I لكننا لا نعرفالـ I في هذه الحالة + +390 +00:32:29,230 --> 00:32:35,190 +ما يمكننا أن نفعله أولاً هو 100000 ÷ 2500 يعني + +391 +00:32:35,190 --> 00:32:40,470 +تحصل على 40 هذا أولاً ثم يجب أن تحرر هذا بالنسبة + +392 +00:32:40,470 --> 00:32:44,410 +لتحرر هذا، يجب أن يكون هذا الجانب اليميني يقل + +393 +00:32:44,410 --> 00:32:50,910 +الجانب اليساري هذا يجب أن يكون 40 ما يمكننا أن + +394 +00:32:50,910 --> 00:32:56,850 +نفعله هو التجارب الخاطئتحاول على سبيل المثال 10% + +395 +00:32:56,850 --> 00:33:00,650 +الترتيب + +396 +00:33:00,650 --> 00:33:06,390 +هو أن تحاول 10% إذا كان هذا أكبر من 40 فتحاول + +397 +00:33:06,390 --> 00:33:13,570 +بقيمة الأسعار أقل من 10% وكذلك ومن خلال الـ + +398 +00:33:13,570 --> 00:33:16,290 +Advanced Finance نستطيع استخدام أفعال معينة محددة + +399 +00:33:16,290 --> 00:33:19,410 +لتحرير هذا الموضوع ولكن في هذه الحالة في مستوىك لا + +400 +00:33:19,410 --> 00:33:23,260 +تحتاج إلى تطبيق هذه الأفعالOkay, so in a + +401 +00:33:23,260 --> 00:33:25,920 +particular .. so you can .. we can use formulas to + +402 +00:33:25,920 --> 00:33:28,920 +.. to solve this problem out by using mathematical + +403 +00:33:28,920 --> 00:33:36,280 +solutions But we can use Excel sheets Okay, we can + +404 +00:33:36,280 --> 00:33:38,880 +apply Excel sheets. I will show you how we can + +405 +00:33:38,880 --> 00:33:43,200 +apply Excel sheets So using Excel + +406 +00:34:03,120 --> 00:34:10,420 +عن طريق اكسل شيط اعود ل .. يجب أن نستخدم حركة + +407 +00:34:10,420 --> 00:34:18,740 +معروفة باسمة ريتز حركة + +408 +00:34:18,740 --> 00:34:23,960 +ريتز + +409 +00:34:23,960 --> 00:34:29,520 +اكسل شيط اكسل + +410 +00:34:29,520 --> 00:34:29,620 +شيط اكسل شيط اكسل شيط اكسل شيط اكسل شيط اكسل شيط + +411 +00:34:29,620 --> 00:34:35,690 +شيط اكسل شيط اكسل شوالقيم الحاضرة وقيم المستقبل + +412 +00:34:35,690 --> 00:34:40,170 +لذلك ال NBA هو عدد المدعومات كم عدد المدعومات لكم + +413 +00:34:40,170 --> 00:34:43,250 +عدد السنين لذلك نحن لدينا عشر سنين فقط تطبيق هذا + +414 +00:34:43,250 --> 00:34:46,630 +في المقارنة لكي ترى كيف يمكنك تطبيقه المدعومات + +415 +00:34:46,630 --> 00:34:54,930 +2500 مليون القيم الحاضرة اليوم هي أزرع وقيم + +416 +00:34:54,930 --> 00:35:00,770 +المستقبل 100000$ لذلك هذه هي الفورمولةOkay, see + +417 +00:35:00,770 --> 00:35:05,910 +how we can apply this in Excel Okay, I think you + +418 +00:35:05,910 --> 00:35:12,170 +are familiar in Excel Because you have Excel Okay, + +419 +00:35:12,370 --> 00:35:19,610 +so the first one is Ampere So how much هي Ampere? + +420 +00:35:21,290 --> 00:35:27,590 +Twenty Okay, and the second is PMT + +421 +00:35:29,980 --> 00:35:41,360 +بمت كم؟ 2500 ثم بي في زرع مستقبلية مستقبلية + +422 +00:35:41,360 --> 00:35:51,800 +مستقبلية مستقبلية مستقبلية مستقبلية مستقبلية + +423 +00:35:58,530 --> 00:36:00,750 +Okay, so if we have one hundred thousand in here + +424 +00:36:00,750 --> 00:36:03,950 +So what is the formula that we will apply the + +425 +00:36:03,950 --> 00:36:07,110 +formula is known as rate just to remember this. So + +426 +00:36:07,110 --> 00:36:11,790 +it's equal rate You + +427 +00:36:11,790 --> 00:36:14,790 +can apply the formulas by just filling these + +428 +00:36:14,790 --> 00:36:19,950 +things the factors or By doing the functions put + +429 +00:36:19,950 --> 00:36:27,560 +in the functions in here and hereالرقم من الواجبات + +430 +00:36:27,560 --> 00:36:39,600 +هو هذا الواجبات هو هذا 2500 القيم الحالية هي 0 قيم + +431 +00:36:39,600 --> 00:36:44,460 +المستقبل هي 100000 ورقم + +432 +00:36:44,460 --> 00:36:53,280 +الواجبات هي هذا حسنا دعونا نعود يجب أن يكون الوقت + +433 +00:36:56,630 --> 00:37:07,430 +It should be like this one hundred thousand okay + +434 +00:37:07,430 --> 00:37:10,610 +is + +435 +00:37:10,610 --> 00:37:22,650 +equal to rate the + +436 +00:37:22,650 --> 00:37:33,430 +paymentالدفع هو الـ NPR20 والدفع + +437 +00:37:33,430 --> 00:37:38,110 +هنا هو هذا والقيم + +438 +00:37:38,110 --> 00:37:46,930 +المستقبلية يجب أن تكون هذه والنسبة + +439 +00:37:46,930 --> 00:37:50,310 +يجب + +440 +00:37:50,310 --> 00:38:01,740 +أن تكون 0 او 1أنا لا أعرف لماذا يوجد مشكلة هنا هذا + +441 +00:38:01,740 --> 00:38:05,920 +هو الرقم 20 2500 + +442 +00:38:05,920 --> 00:38:11,640 +0 100000 لا أعرف لماذا يوجد مشكلة هنا + +443 +00:38:27,310 --> 00:38:35,810 +عشان ايه ايه ايه + +444 +00:38:35,810 --> 00:38:44,410 +ايه ايه + +445 +00:38:44,410 --> 00:38:49,770 +ايه ايه ايه ايه + +446 +00:38:54,430 --> 00:38:59,030 +Okay and you can do the format sales. We will do + +447 +00:38:59,030 --> 00:39:08,230 +it again And It's + +448 +00:39:08,230 --> 00:39:12,910 +five point eighty five percent Okay So why it is + +449 +00:39:12,910 --> 00:39:17,550 +minus because it is cash out of loan we saved So + +450 +00:39:17,550 --> 00:39:22,490 +the rate is one hundred thousand dollarsإذا قمت + +451 +00:39:22,490 --> 00:39:27,390 +بهذا الـ minus حسنا، + +452 +00:39:27,390 --> 00:39:31,170 +هل تريد أن تفعلها مرة أخرى؟ أوه، هذا هو الامر، + +453 +00:39:31,170 --> 00:39:35,070 +حسنًا لماذا + +454 +00:39:35,070 --> 00:39:43,550 +هنا 6.7%؟ سأتفقده + +455 +00:39:50,920 --> 00:39:56,720 +خلّيني أخبرك عن مثلًا آخر هذا + +456 +00:39:56,720 --> 00:40:04,660 +ليس 5000 دولار هذا مثلًا آخر سأخبرك عن مثلًا آخر + +457 +00:40:04,660 --> 00:40:06,880 +سأخبرك عن مثلًا آخر سأخبرك عن مثلًا آخر سأخبرك عن + +458 +00:40:06,880 --> 00:40:14,180 +مثلًا آخر سأخبرك عن مثلًا آخر سأخبرك + +459 +00:40:14,180 --> 00:40:18,120 +عن مثلًا آخر سأخبرك عن مثلًا آخر سأخبرك عن مثلًا + +460 +00:40:18,120 --> 00:40:24,340 +آخرOkay, so what we want him here To know how long + +461 +00:40:24,340 --> 00:40:29,820 +it takes. So we need to calculate N Okay, + +462 +00:40:30,100 --> 00:40:38,200 +we have to calculate N So + +463 +00:40:38,200 --> 00:40:43,580 +we apply the formula here In + +464 +00:40:43,580 --> 00:40:44,200 +this case + +465 +00:40:47,840 --> 00:40:53,560 +the same formula the future value is equal fifty + +466 +00:40:53,560 --> 00:40:59,660 +thousand dollar the payment is five thousand six + +467 +00:40:59,660 --> 00:41:05,040 +thousand I is five percent and we want to + +468 +00:41:05,040 --> 00:41:08,340 +calculate N okay so we will leave this question + +469 +00:41:08,340 --> 00:41:11,620 +for the next meeting and we will answer this okay + +470 +00:41:11,620 --> 00:41:14,700 +ان شاء الله نشوفكم اللقاء الجاي عشان نحل هذا + +471 +00:41:14,700 --> 00:41:16,200 +المثال okay اعطوكوا العافية + diff --git a/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/LQ-9DmDDwYg_raw.json b/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/LQ-9DmDDwYg_raw.json new file mode 100644 index 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1829, 3224, 1975, 1829, 3224, 1975, 1829, 3224, 1975, 1829, 3224, 1975, 1829, 3224, 1975, 1829, 3224, 1975, 1829, 3224, 1975, 1829, 3224, 1975, 1829, 3224], "avg_logprob": -0.5645161098049533, "compression_ratio": 2.9583333333333335, "no_speech_prob": 5.960464477539063e-08, "words": [{"start": 2307.31, "end": 2308.71, "word": "عشان", "probability": 0.5736490885416666}, {"start": 2308.71, "end": 2309.13, "word": " ايه", "probability": 0.30084228515625}, {"start": 2309.13, "end": 2309.19, "word": " ايه", "probability": 0.5274251302083334}, {"start": 2309.19, "end": 2315.81, "word": " ايه", "probability": 0.6337076822916666}, {"start": 2315.81, "end": 2316.05, "word": " ايه", "probability": 0.7444661458333334}, {"start": 2316.05, "end": 2324.41, "word": " ايه", "probability": 0.8234049479166666}, {"start": 2324.41, "end": 2326.21, "word": " ايه", "probability": 0.8663736979166666}, {"start": 2326.21, "end": 2326.65, "word": " ايه", "probability": 0.8932291666666666}, {"start": 2326.65, 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We will do it again And It's five point eighty five percent Okay So why it is minus because it is cash out of loan we saved So the rate is one hundred thousand dollars", "tokens": [8297, 293, 291, 393, 360, 264, 7877, 5763, 13, 492, 486, 360, 309, 797, 400, 467, 311, 1732, 935, 26348, 1732, 3043, 1033, 407, 983, 309, 307, 3175, 570, 309, 307, 6388, 484, 295, 10529, 321, 6624, 407, 264, 3314, 307, 472, 3262, 4714, 3808], "avg_logprob": -0.3563179399656213, "compression_ratio": 1.385135135135135, "no_speech_prob": 0.0, "words": [{"start": 2334.4300000000003, "end": 2335.11, "word": "Okay", "probability": 0.04205322265625}, {"start": 2335.11, "end": 2335.79, "word": " and", "probability": 0.349853515625}, {"start": 2335.79, "end": 2336.85, "word": " you", "probability": 0.8623046875}, {"start": 2336.85, "end": 2337.07, "word": " can", "probability": 0.9638671875}, {"start": 2337.07, "end": 2337.23, "word": " do", "probability": 0.9375}, {"start": 2337.23, "end": 2337.41, "word": " the", 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مثلًا آخر سأخبرك عن مثلًا آخر سأخبرك عن مثلًا آخر سأخبرك عن مثلًا آخر سأخبرك عن مثلًا آخر سأخبرك عن مثلًا آخر سأخبرك عن مثلًا آخر", "tokens": [9778, 1211, 11703, 9957, 1829, 5551, 9778, 26890, 4117, 18871, 50113, 1211, 14111, 995, 19753, 34740, 23758, 32239, 3794, 23777, 11778, 12610, 9640, 23758, 50113, 1211, 14111, 995, 19753, 34740, 8608, 10721, 9778, 26890, 4117, 18871, 50113, 1211, 14111, 995, 19753, 34740, 8608, 10721, 9778, 26890, 4117, 18871, 50113, 1211, 14111, 995, 19753, 34740, 8608, 10721, 9778, 26890, 4117, 18871, 50113, 1211, 14111, 995, 19753, 34740, 8608, 10721, 9778, 26890, 4117, 18871, 50113, 1211, 14111, 995, 19753, 34740, 8608, 10721, 9778, 26890, 4117, 18871, 50113, 1211, 14111, 995, 19753, 34740, 8608, 10721, 9778, 26890, 4117, 18871, 50113, 1211, 14111, 995, 19753, 34740, 8608, 10721, 9778, 26890, 4117, 18871, 50113, 1211, 14111, 995, 19753, 34740, 8608, 10721, 9778, 26890, 4117, 18871, 50113, 1211, 14111, 995, 19753, 34740], "avg_logprob": -0.2746062865407448, 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So we need to calculate N Okay, we have to calculate N So we apply the formula here In this case", "tokens": [8297, 11, 370, 437, 321, 528, 796, 510, 1407, 458, 577, 938, 309, 2516, 13, 407, 321, 643, 281, 8873, 426, 1033, 11, 321, 362, 281, 8873, 426, 407, 321, 3079, 264, 8513, 510, 682, 341, 1389], "avg_logprob": -0.2354029589577725, "compression_ratio": 1.3391304347826087, "no_speech_prob": 0.0, "words": [{"start": 2419.94, "end": 2420.3, "word": "Okay,", "probability": 0.432373046875}, {"start": 2420.46, "end": 2420.72, "word": " so", "probability": 0.578125}, {"start": 2420.72, "end": 2420.98, "word": " what", "probability": 0.94580078125}, {"start": 2420.98, "end": 2421.12, "word": " we", "probability": 0.9443359375}, {"start": 2421.12, "end": 2421.38, "word": " want", "probability": 0.91650390625}, {"start": 2421.38, "end": 2421.58, "word": " him", "probability": 0.66748046875}, {"start": 2421.58, "end": 2421.86, "word": " here", "probability": 0.8134765625}, {"start": 2421.86, "end": 2422.76, "word": " To", "probability": 0.428466796875}, {"start": 2422.76, "end": 2423.74, "word": " know", "probability": 0.568359375}, {"start": 2423.74, "end": 2424.08, "word": " how", "probability": 0.9287109375}, {"start": 2424.08, "end": 2424.34, "word": " long", "probability": 0.9345703125}, {"start": 2424.34, "end": 2424.48, "word": " it", "probability": 0.9599609375}, {"start": 2424.48, "end": 2424.8, "word": " takes.", "probability": 0.81640625}, {"start": 2424.9, "end": 2425.22, "word": " So", "probability": 0.9755859375}, {"start": 2425.22, "end": 2425.44, "word": " we", "probability": 0.95556640625}, {"start": 2425.44, "end": 2425.62, "word": " need", "probability": 0.9384765625}, {"start": 2425.62, "end": 2425.76, "word": " to", "probability": 0.97607421875}, {"start": 2425.76, "end": 2426.14, "word": " calculate", "probability": 0.927734375}, {"start": 2426.14, "end": 2426.48, "word": " N", "probability": 0.399658203125}, {"start": 2426.48, "end": 2429.82, "word": " Okay,", "probability": 0.705078125}, {"start": 2430.1, "end": 2430.58, "word": " we", "probability": 0.9609375}, {"start": 2430.58, "end": 2431.58, "word": " have", "probability": 0.951171875}, {"start": 2431.58, "end": 2431.74, "word": " to", "probability": 0.97021484375}, {"start": 2431.74, "end": 2432.28, "word": " calculate", "probability": 0.92138671875}, {"start": 2432.28, "end": 2433.0, "word": " N", "probability": 0.84033203125}, {"start": 2433.0, "end": 2438.2, "word": " So", "probability": 0.95361328125}, {"start": 2438.2, "end": 2438.4, "word": " we", "probability": 0.9501953125}, {"start": 2438.4, "end": 2438.7, "word": " apply", "probability": 0.9365234375}, {"start": 2438.7, "end": 2438.92, "word": " the", "probability": 0.92724609375}, {"start": 2438.92, "end": 2439.26, "word": " formula", "probability": 0.9296875}, {"start": 2439.26, "end": 2440.28, "word": " here", "probability": 0.8408203125}, {"start": 2440.28, "end": 2443.58, "word": " In", "probability": 0.84716796875}, {"start": 2443.58, "end": 2443.8, "word": " this", "probability": 0.95654296875}, {"start": 2443.8, "end": 2444.2, "word": " case", "probability": 0.9208984375}], "temperature": 1.0}, {"id": 90, "seek": 247619, "start": 2447.84, "end": 2476.2, "text": "the same formula the future value is equal fifty thousand dollar the payment is five thousand six thousand I is five percent and we want to calculate N okay so we will leave this question for the next meeting and we will answer this okay ان شاء الله نشوفكم اللقاء الجاي عشان نحل هذا المثال okay اعطوكوا العافية", "tokens": [3322, 912, 8513, 264, 2027, 2158, 307, 2681, 13442, 4714, 7241, 264, 10224, 307, 1732, 4714, 2309, 4714, 286, 307, 1732, 3043, 293, 321, 528, 281, 8873, 426, 1392, 370, 321, 486, 1856, 341, 1168, 337, 264, 958, 3440, 293, 321, 486, 1867, 341, 1392, 16472, 13412, 16606, 21984, 8717, 8592, 38688, 24793, 13672, 4587, 16606, 25724, 47302, 6225, 8592, 7649, 8717, 5016, 1211, 23758, 9673, 12984, 6027, 1392, 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0.783203125}, {"start": 2454.0, "end": 2455.28, "word": " dollar", "probability": 0.5859375}, {"start": 2455.28, "end": 2456.54, "word": " the", "probability": 0.318359375}, {"start": 2456.54, "end": 2456.98, "word": " payment", "probability": 0.95751953125}, {"start": 2456.98, "end": 2458.52, "word": " is", "probability": 0.96337890625}, {"start": 2458.52, "end": 2458.8, "word": " five", "probability": 0.68798828125}, {"start": 2458.8, "end": 2459.24, "word": " thousand", "probability": 0.86474609375}, {"start": 2459.24, "end": 2459.66, "word": " six", "probability": 0.697265625}, {"start": 2459.66, "end": 2460.14, "word": " thousand", "probability": 0.875}, {"start": 2460.14, "end": 2461.44, "word": " I", "probability": 0.673828125}, {"start": 2461.44, "end": 2462.38, "word": " is", "probability": 0.94970703125}, {"start": 2462.38, "end": 2463.06, "word": " five", "probability": 0.85791015625}, {"start": 2463.06, "end": 2463.5, "word": " percent", "probability": 0.95703125}, {"start": 2463.5, "end": 2464.04, "word": " and", "probability": 0.9580078125}, {"start": 2464.04, "end": 2464.36, "word": " we", "probability": 0.94384765625}, {"start": 2464.36, "end": 2464.92, "word": " want", "probability": 0.91455078125}, {"start": 2464.92, "end": 2465.04, "word": " to", "probability": 0.974609375}, {"start": 2465.04, "end": 2465.6, "word": " calculate", "probability": 0.939453125}, {"start": 2465.6, "end": 2466.36, "word": " N", "probability": 0.68798828125}, {"start": 2466.36, "end": 2467.06, "word": " okay", "probability": 0.6796875}, {"start": 2467.06, "end": 2467.4, "word": " so", "probability": 0.72265625}, {"start": 2467.4, "end": 2467.58, "word": " we", "probability": 0.92236328125}, {"start": 2467.58, "end": 2467.72, "word": " will", "probability": 0.83837890625}, {"start": 2467.72, "end": 2467.88, "word": " leave", "probability": 0.95556640625}, {"start": 2467.88, "end": 2468.04, "word": " this", "probability": 0.93603515625}, {"start": 2468.04, "end": 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"word": " شاء", "probability": 0.970458984375}, {"start": 2472.0, "end": 2472.14, "word": " الله", "probability": 0.95849609375}, {"start": 2472.14, "end": 2472.8, "word": " نشوفكم", "probability": 0.9466552734375}, {"start": 2472.8, "end": 2473.42, "word": " اللقاء", "probability": 0.8017578125}, {"start": 2473.42, "end": 2473.78, "word": " الجاي", "probability": 0.607666015625}, {"start": 2473.78, "end": 2474.08, "word": " عشان", "probability": 0.96728515625}, {"start": 2474.08, "end": 2474.42, "word": " نحل", "probability": 0.9835611979166666}, {"start": 2474.42, "end": 2474.7, "word": " هذا", "probability": 0.90234375}, {"start": 2474.7, "end": 2475.38, "word": " المثال", "probability": 0.8846028645833334}, {"start": 2475.38, "end": 2475.66, "word": " okay", "probability": 0.6904296875}, {"start": 2475.66, "end": 2475.88, "word": " اعطوكوا", "probability": 0.6682535807291666}, {"start": 2475.88, "end": 2476.2, "word": " العافية", "probability": 0.8553059895833334}], "temperature": 1.0}], "language": "ar", "language_probability": 1.0, "duration": 2477.26725, "duration_after_vad": 2271.8612499999917} \ No newline at end of file diff --git a/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/PchAu9C6Hwo_postprocess.srt b/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/PchAu9C6Hwo_postprocess.srt new file mode 100644 index 0000000000000000000000000000000000000000..9760f96d070e68ce51392ce1b555d40daf5361f3 --- /dev/null +++ b/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/PchAu9C6Hwo_postprocess.srt @@ -0,0 +1,1872 @@ +1 +00:00:20,700 --> 00:00:25,100 +بسم الله الرحمن الرحيم في الاجتماع الأخير اتكلم عن + +2 +00:00:25,100 --> 00:00:33,760 +كيف نصنع beta كيف نقدم beta و اليوم سأتكلم عن مثل + +3 +00:00:33,760 --> 00:00:38,680 +كابم كيف نقدم كابم مثل هذا المثل يمكنك الذهاب لمثل + +4 +00:00:38,680 --> 00:00:43,920 +هذا المثل سنجرح مثل هذا المثل بطاقة مثل هذه حسنا؟ + +5 +00:00:43,920 --> 00:00:51,770 +لذلك سنستخدم كابمالمقارنة التي اتكلمت عنها في + +6 +00:00:51,770 --> 00:00:58,210 +المقابلة السابقة فقط لأذكركم بمعرفة كبام المعادة + +7 +00:00:58,210 --> 00:01:06,070 +المتوقعة هي مفهوم رف رف هو الـ risk-free plus beta + +8 +00:01:06,070 --> 00:01:14,070 +RM minus RF ونحن نشرح بأن هذا RM minus RF هو الـ + +9 +00:01:14,070 --> 00:01:14,910 +risk premium + +10 +00:01:17,810 --> 00:01:21,190 +وهذا بيطا بيطا هو عدد عدد عدد عدد عدد عدد عدد عدد + +11 +00:01:21,190 --> 00:01:21,290 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +12 +00:01:21,290 --> 00:01:26,050 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +13 +00:01:26,050 --> 00:01:26,190 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +14 +00:01:26,190 --> 00:01:27,150 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +15 +00:01:27,150 --> 00:01:47,170 +عدد عدد عد + +16 +00:01:48,320 --> 00:01:55,140 +حسنًا، لدينا ثلاثة مستخدمات مختلفة، Apple، Dell و + +17 +00:01:55,140 --> 00:02:03,860 +HP، البيتا من Apple هي 2.90 و من ال Yahoo، Dell 1 + +18 +00:02:03,860 --> 00:02:13,130 +.81 و 1.27هذه بيطة كمعرفة من يهوو بيطة كمعرفة من + +19 +00:02:13,130 --> 00:02:24,330 +أمازون هي 2.58% لأبل 1.37% لديل 1.47% ل HP إذا كنا + +20 +00:02:24,330 --> 00:02:31,490 +نريد أن نعرف عدد العودة المتوقع من عدد عدد عدد عدد + +21 +00:02:31,490 --> 00:02:31,790 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +22 +00:02:31,790 --> 00:02:32,750 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +23 +00:02:32,750 --> 00:02:36,230 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +24 +00:02:36,230 --> 00:02:42,490 +عوالـ RM الـ + +25 +00:02:42,490 --> 00:02:47,410 +risk-free بالنسبة لل .. بالنسبة للأمثلة ال risk + +26 +00:02:47,410 --> 00:02:53,870 +-free هو 4.5% و + +27 +00:02:53,870 --> 00:03:06,750 +RM minus RF هو 6% نعم ال risk premium هو 6%دعونا + +28 +00:03:06,750 --> 00:03:17,770 +نطبق أولاً ما لدينا هو الوصول المتوقع لـ Apple يقل + +29 +00:03:17,770 --> 00:03:24,550 +الـ Rescue Free 4.5% plus Beta ماهي Beta لـ Apple؟ + +30 +00:03:24,550 --> 00:03:28,710 +2.9×6 + +31 +00:03:28,710 --> 00:03:33,630 +% فتحاول + +32 +00:03:33,630 --> 00:03:43,260 +تخطيط هذا21.90% 21.90% فهذا هو حجم الوقت المتوقع + +33 +00:03:43,260 --> 00:03:49,060 +للعادة فهو + +34 +00:03:49,060 --> 00:03:53,020 +صح؟ نعم فقط دوبل تشك + +35 +00:04:11,980 --> 00:04:18,340 +حسنا دعونا نحاول ديل دعونا + +36 +00:04:18,340 --> 00:04:23,060 +نحاول ديل مرة + +37 +00:04:23,060 --> 00:04:32,000 +أخرى، عدد المعادلة المتوقع لديل 4.5% أكتر من 4.5% + +38 +00:04:32,000 --> 00:04:33,000 +أكتر من 4.5% أكتر من 4.5% أكتر من 4.5% أكتر من 4.5 + +39 +00:04:33,000 --> 00:04:33,180 +% أكتر من 4.5% أكتر من 4.5% أكتر من 4.5% أكتر من 4 + +40 +00:04:33,180 --> 00:04:37,670 +من 4.5% أكتر من 4.5% أكتر من 4.5% أكتر من 41.81×6% + +41 +00:04:37,670 --> 00:04:42,130 +تذكر أن 6% هو الفرصة بين إعادة السوق وإعادة + +42 +00:04:42,130 --> 00:04:52,610 +المخاطر حسنًا، فإذا النتيجة ما هي 15.36 + +43 +00:04:52,610 --> 00:04:58,070 +% الأخيرة لتخطيط قيمة إعادة الـ HP + +44 +00:05:02,900 --> 00:05:10,780 +4.5% 4.5% 4.5% 4.5% 4.5% 4.5% 4.5% 4.5% 4.5% 4.5% + +45 +00:05:10,780 --> 00:05:11,240 +4.5% 4.5% 4.5% 4.5% 4.5% 4.5% 4.5% 4.5% 4.5% 4.5% + +46 +00:05:11,240 --> 00:05:11,780 +4.5% 4.5% 4.5% 4.5% 4.5% 4.5% 4.5% 4.5% 4.5% 4.5% + +47 +00:05:11,780 --> 00:05:12,260 +4.5% 4.5% 4.5% 4.5% 4.5% 4.5% 4.5% 4.5% 4.5% 4.5% + +48 +00:05:12,260 --> 00:05:15,420 +4.5% 4.5% 4.5% 4.5% 4.5% 4.5% + +49 +00:05:31,270 --> 00:05:35,890 +بيتا هي and the expected rate of return in here + +50 +00:05:35,890 --> 00:05:41,570 +what you observe say + +51 +00:05:41,570 --> 00:05:45,390 +there is a positive relation a positive relation + +52 +00:05:45,390 --> 00:05:52,350 +say it again please yes increases yes that's right + +53 +00:05:52,350 --> 00:05:54,030 +okay anything else + +54 +00:05:56,900 --> 00:06:01,940 +عندما تزداد بيتا، فرق المطاولة للعودة تزداد، + +55 +00:06:01,940 --> 00:06:07,500 +لماذا؟ لأن هناك حرارة إضافية، لأن هناك حرارة + +56 +00:06:07,500 --> 00:06:14,280 +إضافية، لذلك المؤسسات يطلبون التجارب لتحميل حرارة + +57 +00:06:14,280 --> 00:06:26,080 +إضافية، أي سؤال؟ + +58 +00:06:29,020 --> 00:06:37,040 +Okay, so we can conclude that increases in beta as + +59 +00:06:37,040 --> 00:06:40,680 +we observe in this line increases in beta will + +60 +00:06:40,680 --> 00:06:51,180 +increase the required rate of return Okay, + +61 +00:06:51,300 --> 00:06:53,760 +the last things just remind you with the key terms + +62 +00:06:54,620 --> 00:06:59,920 +مقارنة بيطا هي مقارنة تجارب السيستماتيك والمقارنة + +63 +00:06:59,920 --> 00:07:03,220 +هي مقارنة تجارب كل حماية في تجارب السيستماتيك، + +64 +00:07:03,220 --> 00:07:08,640 +كمعاملة تسوي الأسطس المالية تسوي قيمة العودة في + +65 +00:07:08,640 --> 00:07:16,370 +تجارب معينةالتقارير هو التقارير الوحيد بين + +66 +00:07:16,370 --> 00:07:23,650 +اتجارتين. باستخدام الانتجار نستطيع ان نحرر فرصة + +67 +00:07:23,650 --> 00:07:29,790 +فرصة غير مستسامةالـ device for risk هذا مرتبط + +68 +00:07:29,790 --> 00:07:30,470 +بالرغم من الرغم من الرغم من الرغم من الرغم من + +69 +00:07:30,470 --> 00:07:32,410 +الرغم من الرغم من الرغم من الرغم من الرغم من الرغم + +70 +00:07:32,410 --> 00:07:32,790 +من الرغم من الرغم من الرغم من الرغم من الرغم من + +71 +00:07:32,790 --> 00:07:34,450 +الرغم من الرغم من الرغم من الرغم من الرغم من الرغم + +72 +00:07:34,450 --> 00:07:36,950 +من الرغم من الرغم من الرغم من الرغم من الرغم من + +73 +00:07:36,950 --> 00:07:37,030 +الرغم من الرغم من الرغم من الرغم من الرغم من الرغم + +74 +00:07:37,030 --> 00:07:38,190 +من الرغم من الرغم من الرغم من الرغم من الرغم من + +75 +00:07:38,190 --> 00:07:44,030 +الرغم من الرغم من الرغم من الرغم من + +76 +00:07:48,630 --> 00:07:53,850 +بورتفاليو بيتا مجرد شعور البرتفالي لتغيير + +77 +00:07:53,850 --> 00:07:59,390 +الأساسيات في الأسواق سيكورتي ماركت لاين تظهر الشيء + +78 +00:07:59,390 --> 00:08:04,450 +بإن كل السيكورتيات يجب أن تكون تظهر في سيكورتي + +79 +00:08:04,450 --> 00:08:08,150 +ماركت لاين ونفسنا نشرح الفرق بين حرص مستعمر + +80 +00:08:08,150 --> 00:08:11,030 +ومستعمر غير مستعمر حرص مستعمر حرص غير مستعمر حرص + +81 +00:08:11,030 --> 00:08:12,810 +غير مستعمر حرص غير مستعمر حرص غير مستعمر حرص غير + +82 +00:08:12,810 --> 00:08:17,370 +مستعمر حرص غير مستعمر حرص غير مستعمر حرص + +83 +00:08:20,660 --> 00:08:31,400 +Okay so now moving to chapter eleven sorry + +84 +00:08:31,400 --> 00:08:35,280 +I + +85 +00:08:35,280 --> 00:08:41,480 +think we have only one chapter after this okay + +86 +00:08:41,480 --> 00:08:46,220 +let's move to this chapter then we will talk okay + +87 +00:08:47,430 --> 00:08:52,790 +Save your discussion to the last chapter. Okay now + +88 +00:08:52,790 --> 00:08:58,350 +investment decision criteria and you know + +89 +00:08:58,350 --> 00:09:03,250 +companies to + +90 +00:09:03,250 --> 00:09:07,890 +keep themselves growing and stable and to compete + +91 +00:09:07,890 --> 00:09:14,690 +in the market they should suggest investment + +92 +00:09:14,690 --> 00:09:20,490 +opportunitiesلأن هناك اتفاق في السوق و لأن هناك + +93 +00:09:20,490 --> 00:09:28,950 +اتفاق في السوق و أن الشركات يجب أن تتعامل على فرصة + +94 +00:09:28,950 --> 00:09:37,090 +الاستثمار لكي تتعامل في السوق، فهذا + +95 +00:09:37,090 --> 00:09:42,950 +الفيديو يركز على قرار الإستثمار وكيف نقدر + +96 +00:09:43,840 --> 00:09:53,260 +الفرصات في السوق أو في السوق لماذا من المهم أن + +97 +00:09:53,260 --> 00:10:00,860 +ندرس الاستثمار؟ لأن الاستثمار يأثر على قيمة السوق + +98 +00:10:00,860 --> 00:10:06,800 +والقيمة السوقية كما ذكرنا قبلها لديها تأثير مباشر + +99 +00:10:06,800 --> 00:10:13,380 +على مجموعات الماللذلك، لكي نقوم بالتحقيق أو لكي + +100 +00:10:13,380 --> 00:10:14,660 +نقوم بالتحقيق أو لكي نقوم بالتحقيق أو لكي نقوم + +101 +00:10:14,660 --> 00:10:16,840 +بالتحقيق أو لكي نقوم بالتحقيق أو لكي نقوم بالتحقيق + +102 +00:10:16,840 --> 00:10:17,980 +أو لكي نقوم بالتحقيق أو لكي نقوم بالتحقيق أو لكي + +103 +00:10:17,980 --> 00:10:19,460 +نقوم بالتحقيق أو لكي نقوم بالتحقيق أو لكي نقوم + +104 +00:10:19,460 --> 00:10:23,180 +بالتحقيق أو لكي نقوم بالتحقيق أو لكي نقوم بالتحقيق + +105 +00:10:23,180 --> 00:10:26,400 +أو لكي نقوم بالتحقيق أو لكي نقوم بالتحقيق أو لكي + +106 +00:10:26,400 --> 00:10:28,060 +نقوم بالتحقيق أو لكي نقوم بالتحقيق أو لكي نقوم + +107 +00:10:28,060 --> 00:10:38,940 +بالتحقيق أو + +108 +00:10:38,940 --> 00:10:44,360 +لكي نالمحتوى الصحيح والأولى مهتمين للتعليم + +109 +00:10:44,360 --> 00:10:49,380 +والقواعد تتطور في هذا الحلقه مقارنة كفاية المدفع + +110 +00:10:49,380 --> 00:10:56,940 +فقط لأذكركم في هذا الحلقه نحن نتكلم عن هذا الاسم + +111 +00:10:56,940 --> 00:11:04,760 +Fixed Assets فهذا يسمى كفاية المدفع أو Investment + +112 +00:11:09,570 --> 00:11:16,610 +هذه المنطقة اللي نتكلم عنها في هذا الفيديو So an + +113 +00:11:16,610 --> 00:11:19,390 +overview of capital budgeting how we take + +114 +00:11:19,390 --> 00:11:23,870 +decisions related to the capital budgeting using + +115 +00:11:23,870 --> 00:11:26,650 +the net present value one of the most important + +116 +00:11:29,120 --> 00:11:34,500 +الخاصة هي أننا نتعامل بالعمل ونستخدم خاصة أخرى من + +117 +00:11:34,500 --> 00:11:38,360 +المستخدمات مثل أسعار الميزانية العامة، عدد الدفع + +118 +00:11:38,360 --> 00:11:42,620 +الداخلي، ومقالات الدفع الداخلية وخاصة أخرى لماذا + +119 +00:11:42,620 --> 00:11:48,820 +قمنا بتقرير هذا؟ لأن هذا هو أهم شيء وكثير من العمل + +120 +00:11:48,820 --> 00:11:55,470 +يستخدمون قيمة الانترنتثم نتكلم عن الهدف الواقعي + +121 +00:11:55,470 --> 00:12:01,090 +للدراسة المالية في حياة العمل. وخلاصًا، الكلمات + +122 +00:12:01,090 --> 00:12:06,550 +المهمة المستخدمة واجهتها في هذه القصة، الهدف + +123 +00:12:06,550 --> 00:12:09,810 +الأساسي للتعلم هو أنه يفهم كيف تنفيذ مصادر وخطوط + +124 +00:12:09,810 --> 00:12:16,270 +استثمار مستخدمبسبب أننا نعيش في مجالات مقارنة + +125 +00:12:16,270 --> 00:12:23,050 +وإمكانات الاستثمار محدودة جدًا، فما هي الأدوات + +126 +00:12:23,050 --> 00:12:27,470 +التي يمكننا إستخدامها لتعامل مع إمكانات الاستثمار؟ + +127 +00:12:27,470 --> 00:12:33,710 +ثانيًا، تحقق إمكانات الاستثمار، وفي الأولة، نعرف + +128 +00:12:33,710 --> 00:12:38,490 +إمكانات الاستثمار الرئيسيةنحن نحاول أن نفكر في أين + +129 +00:12:38,490 --> 00:12:43,230 +ندفع المال لنا لدينا فرصة مختلفة، دعنا نقول خمس + +130 +00:12:43,230 --> 00:12:47,290 +فرصة، و الآن في الـ number two لنقوم بالتعامل + +131 +00:12:47,290 --> 00:12:53,130 +بينهم و لنرى إذا واحد أفضل من اتين أو خمس أفضل من + +132 +00:12:53,130 --> 00:12:56,290 +واحد فإن نقوم بالتعامل في هذه الفرصة باستخدام قيمة + +133 +00:12:56,290 --> 00:13:04,170 +موجودة فيها، وهي عملية أهمية لنقوم بتعامل قيمة + +134 +00:13:04,170 --> 00:13:05,510 +موجودة في مجموعات المال + +135 +00:13:08,560 --> 00:13:13,620 +سنقوم بتطبيقات أخرى مثلًا نسبة المستخدمات نسبة + +136 +00:13:13,620 --> 00:13:14,580 +المستخدمات نسبة المستخدمات نسبة نسبة نسبة نسبة + +137 +00:13:14,580 --> 00:13:15,200 +نسبة نسبة نسبة نسبة نسبة نسبة نسبة نسبة نسبة نسبة + +138 +00:13:15,200 --> 00:13:18,720 +نسبة نسبة نسبة نسبة نسبة نسبة نسبة نسبة نسبة نسبة + +139 +00:13:18,720 --> 00:13:19,640 +نسبة نسبة نسبة نسبة نسبة نسبة نسبة نسبة نسبة نسبة + +140 +00:13:19,640 --> 00:13:20,220 +نسبة نسبة نسبة نسبة نسبة نسبة نسبة نسبة نسبة نسبة + +141 +00:13:20,220 --> 00:13:25,780 +نسبة نسبة نسبة نسبة نسبة + +142 +00:13:25,780 --> 00:13:29,160 +نسبة نسبة نسبة نسبة نسبة نسبة نسبة نسبة نسبة نسبة + +143 +00:13:29,160 --> 00:13:32,200 +نسبة + +144 +00:13:32,200 --> 00:13:35,840 +نسبة + +145 +00:13:36,170 --> 00:13:40,390 +أدرس كيف يصنعوا أفكار مرتبطة بالفرصات المستخدمة + +146 +00:13:40,390 --> 00:13:47,670 +فقط تعتبر هذا المثال هنا إذا كنت رئيس شركة، دعنا + +147 +00:13:47,670 --> 00:13:54,570 +نقول شركة موجودة وانت تفكر في المستقبل وانت لديك + +148 +00:13:54,570 --> 00:13:58,550 +المال اضافي لتشغيل + +149 +00:13:58,550 --> 00:14:04,770 +مستخدم جديدماذا هو البرنامج؟ وانا أعرف أنك في + +150 +00:14:04,770 --> 00:14:09,130 +الوظيفة التجارية لأن فقط تفكير في هنا في التعامل + +151 +00:14:09,130 --> 00:14:14,270 +أو الانبعاد ما يمكنك أن تفعله لتنمية فرص الانبعاد + +152 +00:14:14,270 --> 00:14:20,110 +أو فكيرات مرتبطة بالفرص الانبعاد فماذا يمكنك أن + +153 +00:14:20,110 --> 00:14:23,510 +تفعله؟ لأن هذا هو النقطة البداية في فهم الانبعاد + +154 +00:14:23,510 --> 00:14:32,600 +حسنا، فماذا يمكنك أن تفعله؟ أنت مدير ولسه مااخدناش + +155 +00:14:32,600 --> 00:14:34,580 +strategic management .. no this is in strategic + +156 +00:14:34,580 --> 00:14:39,160 +management .. sorry .. most .. I think most of + +157 +00:14:39,160 --> 00:14:42,100 +students are enrolled in the strategic management + +158 +00:14:42,100 --> 00:14:45,260 +.. so why you asking me oh we have strategic + +159 +00:14:45,260 --> 00:14:49,260 +management we don't have time and so now .. sorry + +160 +00:14:49,260 --> 00:14:56,230 +say it again pleaseplanning okay planning of what? + +161 +00:14:57,130 --> 00:14:59,530 +planning ال .. ال .. ال .. ال .. ال .. ال .. ال .. + +162 +00:14:59,530 --> 00:14:59,950 +ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال + +163 +00:14:59,950 --> 00:15:01,050 +.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. + +164 +00:15:01,050 --> 00:15:01,250 +ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال + +165 +00:15:01,250 --> 00:15:02,190 +.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. + +166 +00:15:02,190 --> 00:15:03,950 +ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال + +167 +00:15:03,950 --> 00:15:03,970 +.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. + +168 +00:15:03,970 --> 00:15:04,190 +ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال + +169 +00:15:04,190 --> 00:15:05,430 +.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. + +170 +00:15:05,430 --> 00:15:05,450 +ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال + +171 +00:15:05,450 --> 00:15:06,950 +ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال + +172 +00:15:06,950 --> 00:15:12,210 +.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. + +173 +00:15:18,760 --> 00:15:22,040 +it's what analysis for the environment to see + +174 +00:15:22,040 --> 00:15:26,040 +compared to the market performance what's the + +175 +00:15:26,040 --> 00:15:30,280 +market need then we look to our internal + +176 +00:15:30,280 --> 00:15:33,120 +environment what we have what do you mean internal + +177 +00:15:33,120 --> 00:15:37,320 +environment? it's the ability of the organization + +178 +00:15:37,320 --> 00:15:41,160 +to serve the needs of the marketOkay, so you are + +179 +00:15:41,160 --> 00:15:44,640 +observing what the external environment needs or + +180 +00:15:44,640 --> 00:15:47,520 +asking, then you move to the internal environment + +181 +00:15:47,520 --> 00:15:51,560 +whether to match the ability of .. Okay, but in + +182 +00:15:51,560 --> 00:15:57,960 +practice they do this؟ This is in academic you are + +183 +00:15:57,960 --> 00:16:01,140 +right, but in practice academic life is different + +184 +00:16:01,140 --> 00:16:10,240 +So let's talk about Appleهل أبل تذهب إلى الوضع + +185 +00:16:10,240 --> 00:16:14,800 +الخارجي و تسألهم ماذا يمكننا أن نفعل؟ او هم لديهم + +186 +00:16:14,800 --> 00:16:18,580 +شيء مختلف؟ هم لديهم شيء مختلف؟ هم لديهم شيء مختلف؟ + +187 +00:16:18,580 --> 00:16:20,740 +هم لديهم شيء مختلف؟ هم لديهم شيء مختلف؟ هم لديهم + +188 +00:16:20,740 --> 00:16:25,680 +شيء مختلف؟ هم لديهم + +189 +00:16:25,680 --> 00:16:30,760 +شيء مختلف؟ هم + +190 +00:16:33,770 --> 00:16:38,470 +بعض الوقت عندما نتحدث عن شركات كبيرة، الشركات + +191 +00:16:38,470 --> 00:16:42,530 +الكبيرة تحاول أن تسيطر على المشروع أو يعرفها + +192 +00:16:42,530 --> 00:16:46,950 +كمعلمة في المشروع، هذا مثال بسيط جدا، أنت محق، نحن + +193 +00:16:46,950 --> 00:16:51,310 +ننظر إلى البيئة الخارجية، ثم نقابل البيئة الداخلية + +194 +00:16:51,310 --> 00:16:57,030 +ونرى، نستطيع أن يكون هناك عالم معرفة ونسألهم ما هي + +195 +00:16:57,030 --> 00:17:01,430 +فرصة الاستثمار، نستطيع أن نسأل الحكومة، نسأل + +196 +00:17:01,430 --> 00:17:09,160 +الشركات التجارية، هذا بخيرولكن لشركات كبيرة، أول + +197 +00:17:09,160 --> 00:17:16,760 +خطوة هي أن تطلبوا من عميلها عميلها عميلها + +198 +00:17:16,760 --> 00:17:17,640 +عميلها عميلها عميلها عميلها عميلها عميلها عميلها + +199 +00:17:17,640 --> 00:17:17,660 +عميلها عميلها عميلها عميلها عميلها عميلها عميلها + +200 +00:17:17,660 --> 00:17:17,840 +عميلها عميلها عميلها عميلها عميلها عميلها عميلها + +201 +00:17:17,840 --> 00:17:17,860 +عميلها عميلها عميلها عميلها عميلها عميلها عميلها + +202 +00:17:17,860 --> 00:17:29,600 +عميلها عميلها عميلها عميلها عميلها + +203 +00:17:29,600 --> 00:17:36,840 +علماذا؟ لأن الوظيفة العملية الأسفة تتقابل مباشرة + +204 +00:17:36,840 --> 00:17:41,860 +مع المستخدمين ويعرفوا بالضبط ما يريده المستخدمين + +205 +00:17:41,860 --> 00:17:46,960 +مثلما يكونوا لديهم المعلومات أو البيانات عن + +206 +00:17:46,960 --> 00:17:50,220 +المستخدمين، ماذا يتبعه المستخدم، ماذا يحتاجه، ماذا + +207 +00:17:50,220 --> 00:17:51,720 +يحتاجه، ماذا يحتاجه، ماذا يحتاجه، ماذا يحتاجه، + +208 +00:17:51,720 --> 00:17:51,800 +ماذا يحتاجه، ماذا يحتاجه، ماذا يحتاجه، ماذا + +209 +00:17:51,800 --> 00:17:52,480 +يحتاجه، ماذا يحتاجه، ماذا يحتاجه، ماذا يحتاجه، + +210 +00:17:52,480 --> 00:17:52,760 +ماذا يحتاجه، ماذا يحتاجه، ماذا يحتاجه، ماذا + +211 +00:17:52,760 --> 00:17:56,860 +يحتاجه، ماذا يحتاجه + +212 +00:18:00,080 --> 00:18:03,800 +So first of all they try to generate ideas from + +213 +00:18:03,800 --> 00:18:08,280 +the business and involve all of the business + +214 +00:18:08,280 --> 00:18:12,480 +levels in taking the opportunity or investment + +215 +00:18:12,480 --> 00:18:16,560 +opportunities. They are involved in all of the + +216 +00:18:16,560 --> 00:18:20,550 +business processعلى سبيل المثال، إذا كنا نتكلم عن + +217 +00:18:20,550 --> 00:18:24,890 +الـ IOG هنا في مدرسة الإسلامية في غزا من المهم أن + +218 +00:18:24,890 --> 00:18:29,310 +نتكلم عن مستوى التدريب الأسفل أو أن نتكلم عن مستوى + +219 +00:18:29,310 --> 00:18:32,950 +التدريب الأسفل لأنهم يتقابلوا مع الطلاب ويعرفوا ما + +220 +00:18:32,950 --> 00:18:39,350 +يريده الطلاب هذا مهم، ثم هذه الأفكار تذهب إلى + +221 +00:18:39,350 --> 00:18:42,270 +مستوى التدريب الأعلى وفي مستوى التدريب الأعلى + +222 +00:18:42,270 --> 00:18:47,810 +يفكروا في مجالات مختلفة، على سبيل المثال إذاجميع + +223 +00:18:47,810 --> 00:18:55,170 +مرحلات الوظيفة تقدم 100 أفكار وفقًا للحفظ العلمي + +224 +00:18:55,170 --> 00:19:03,570 +ربما فقط 3% من هذه الأفكار مقبولة، فمن 100 أفكار + +225 +00:19:03,570 --> 00:19:10,710 +فقط لدينا 3% من هذه الأفكار، ففقًا للعمل، أكتر + +226 +00:19:10,710 --> 00:19:13,830 +تخلص أفكار، أكتر يمكنك أن تقاتل في السوق + +227 +00:19:16,800 --> 00:19:19,900 +Okay, so out of one hundred ideas you have three + +228 +00:19:19,900 --> 00:19:24,800 +acceptable ideas So + +229 +00:19:24,800 --> 00:19:28,360 +this is just very little example how they do their + +230 +00:19:28,360 --> 00:19:32,000 +business or a particular example in create + +231 +00:19:32,000 --> 00:19:37,980 +investment opportunities Do + +232 +00:19:37,980 --> 00:19:39,840 +you think it's important to involve lower + +233 +00:19:39,840 --> 00:19:41,000 +management level? Yes + +234 +00:19:44,300 --> 00:19:47,000 +هي هي they collect information but in a different + +235 +00:19:47,000 --> 00:19:52,340 +way؟ yes but starting from the business for + +236 +00:19:52,340 --> 00:19:57,360 +instance if you talk about the palatial they first + +237 +00:19:57,360 --> 00:20:00,500 +start the people who are interfaced with the + +238 +00:20:00,500 --> 00:20:03,520 +customers they are working in palatial if you talk + +239 +00:20:03,520 --> 00:20:07,560 +about pop bank of Palestineالأولاء يسألونهم ما + +240 +00:20:07,560 --> 00:20:11,700 +يمكننا أن نفعله، أعطينا فكرة، لأنهم الناس الذين + +241 +00:20:11,700 --> 00:20:15,620 +يعرفوا ما هي حركتهم المستخدمين وما هي حركتهم + +242 +00:20:15,620 --> 00:20:20,360 +المستخدمين وما هي مناسبة للمستخدمين، لأنهم أول مرة + +243 +00:20:20,360 --> 00:20:28,530 +مع المستخدمينفي النهاية، نحن نمتزج مستخدمنا، فمن + +244 +00:20:28,530 --> 00:20:32,210 +يعرف المستخدمين؟ الناس الذين يعملون في المشروع، + +245 +00:20:32,210 --> 00:20:35,990 +وفي الواضح أنهم يقعدون مقابل مقابل مع مستخدمهم، + +246 +00:20:35,990 --> 00:20:39,690 +وليس مع المستخدمين الذين يقعدون في مصطلح طبيعي + +247 +00:20:39,690 --> 00:20:40,090 +للهواء + +248 +00:20:43,530 --> 00:20:47,230 +لأنهم فقط يقفزون الشركة من طريق طريق طريق طريق + +249 +00:20:47,230 --> 00:20:47,410 +طريق طريق طريق طريق طريق طريق طريق طريق طريق طريق + +250 +00:20:47,410 --> 00:20:48,530 +طريق طريق طريق طريق طريق طريق طريق طريق طريق طريق + +251 +00:20:48,530 --> 00:20:48,590 +طريق طريق طريق طريق طريق طريق طريق طريق طريق طريق + +252 +00:20:48,590 --> 00:20:50,150 +طريق طريق طريق طريق طريق طريق طريق طريق طريق طريق + +253 +00:20:50,150 --> 00:20:50,590 +طريق طريق طريق طريق طريق طريق طريق طريق طريق طريق + +254 +00:20:50,590 --> 00:20:51,170 +طريق طريق طريق طريق طريق طريق طريق طريق طريق طريق + +255 +00:20:51,170 --> 00:20:57,170 +طريق طريق طريق طريق طريق طريق + +256 +00:21:09,100 --> 00:21:15,720 +ليس فقط عمل أشياء تدخل البيانات، إنها أشياء + +257 +00:21:15,720 --> 00:21:20,840 +مستخدمة جدًا كابلان و نورتون، هل تعرفون كابلان و + +258 +00:21:20,840 --> 00:21:25,540 +نورتون؟ كابلان و نورتون الذين قموا بحفظ شيء يسمى + +259 +00:21:25,540 --> 00:21:26,400 +بالنسبة بالنسبة بالنسبة بالنسبة بالنسبة بالنسبة + +260 +00:21:26,400 --> 00:21:31,060 +بالنسبة بالنسبة بالنسبة بالنسبة بالنسبة بالنسبة + +261 +00:21:31,060 --> 00:21:31,160 +بالنسبة بالنسبة بالنسبة بالنسبة بالنسبة بالنسبة + +262 +00:21:31,160 --> 00:21:31,200 +بالنسبة بالنسبة بالنسبة بالنسبة بالنسبة بالن + +263 +00:21:34,030 --> 00:21:38,870 +balance scorecard. It is a strategic tool to + +264 +00:21:38,870 --> 00:21:41,750 +develop the strategic performance of the business. + +265 +00:21:43,090 --> 00:21:46,730 +Norton and Kaplan they want to show the importance + +266 +00:21:46,730 --> 00:21:50,510 +even for the cleaners in the business. He came to + +267 +00:21:50,510 --> 00:21:54,650 +the cleaner and asked him what is what you working + +268 +00:21:54,650 --> 00:21:59,910 +and he said just I'm cleaninghe said okay it means + +269 +00:21:59,910 --> 00:22:02,790 +you are not doing anything you are just cleaning + +270 +00:22:02,790 --> 00:22:06,850 +we can't bring anyone and clean this he want to + +271 +00:22:06,850 --> 00:22:10,110 +tell him a message that he is important to the + +272 +00:22:10,110 --> 00:22:15,490 +business so what is the message if you stop + +273 +00:22:15,490 --> 00:22:19,500 +cleaningSo the students or the let's say the + +274 +00:22:19,500 --> 00:22:22,080 +customers they are not feeling well and they will + +275 +00:22:22,080 --> 00:22:24,960 +leave this business, this is very simple, we are + +276 +00:22:24,960 --> 00:22:28,540 +not talking about the services itself or the + +277 +00:22:28,540 --> 00:22:30,520 +mobile phone industries, we are looking at the + +278 +00:22:30,520 --> 00:22:35,830 +cleaners, to what extent they are importantبالعمل + +279 +00:22:35,830 --> 00:22:40,710 +وفي نفس الوضع نحن ننظر إلى الناس التي تتعامل مع + +280 +00:22:40,710 --> 00:22:45,890 +المستخدمين هذه هي طريقة نجتمع فرصة الاستثمار + +281 +00:22:45,890 --> 00:22:51,630 +بالإضافة إلى ما قلتيت نستطيع رؤية أصدقائنا ولكن + +282 +00:22:51,630 --> 00:22:56,570 +المشكلة في رؤية أصدقائك أنك تحاول أن تتعقب عليهم + +283 +00:22:56,570 --> 00:23:02,790 +فهو مثلyou are copying others, so there is no + +284 +00:23:02,790 --> 00:23:05,890 +creativity in your business because you are + +285 +00:23:05,890 --> 00:23:08,550 +copying them, see what they are doing, they are + +286 +00:23:08,550 --> 00:23:11,670 +providing touchscreen, mobile phones, then you can + +287 +00:23:11,670 --> 00:23:15,310 +do this, so there is no creativity in doing this, + +288 +00:23:15,550 --> 00:23:20,880 +if you ask the government the sameالمهم أن تكون + +289 +00:23:20,880 --> 00:23:25,300 +لديك فكرة مخلصة باستخدام مصادر مختلفة ومصادر + +290 +00:23:25,300 --> 00:23:28,080 +مختلفة المصادر المصادر المخلصة تتطور في هذا + +291 +00:23:28,080 --> 00:23:33,100 +الفيديو كاش فلوز هم مصادر قيمة مهم جدًا ما تجعل + +292 +00:23:33,100 --> 00:23:34,920 +مصادر مصادر كاش فلوزك تجعل مصادر كاش فلوزك تجعل + +293 +00:23:34,920 --> 00:23:39,500 +مصادر كاش فلوزك تجعل مصادر كاش فلوزك تجعل مصادر + +294 +00:23:39,500 --> 00:23:41,840 +كاش فلوزك تجعل مصادر كاش فلوزك تجعل مصادر كاش + +295 +00:23:41,840 --> 00:23:42,680 +فلوزك تجعل مصادر كاش فلوزك تجعل مصادر كاش فلوزك + +296 +00:23:42,680 --> 00:23:47,280 +تجعل مصادر كاش ف + +297 +00:23:49,590 --> 00:23:52,910 +بسبب أن المال لا يأتي فقط في السنة الأولى، بل يأتي + +298 +00:23:52,910 --> 00:23:56,790 +في الحياة المتطورة، فالمال لديه قيمة في الوقت. + +299 +00:23:59,010 --> 00:24:03,110 +هناك اتفاق بين المساعدة والعادة، لدينا فرصة + +300 +00:24:03,110 --> 00:24:08,550 +للاستثمار مختلفة، فهذه الفرصة للاستثمار لديها فرصة + +301 +00:24:08,550 --> 00:24:11,650 +مختلفة وعادة مختلفة، لذلك نريد أن نتعامل مع + +302 +00:24:11,650 --> 00:24:16,540 +المساعدة والعادة لكل فرصةوالعامات السوقية تشير إلى + +303 +00:24:16,540 --> 00:24:21,280 +المعلومات إذا كان لدينا مشروع انفجار ناجح سينفع + +304 +00:24:21,280 --> 00:24:26,400 +على عاملنا لأن المستخدمين سينفعوا عن هذه الفرصة + +305 +00:24:26,400 --> 00:24:32,780 +ومن ثم يشيروا إلى حركتهم على السعر دعونا نتحدث عن + +306 +00:24:32,780 --> 00:24:40,600 +تنظيم المصادر الماليةهذا مثال بسيط عن ديزني لاند، + +307 +00:24:40,600 --> 00:24:46,260 +قرر ديزني لاند ان يستخدم 70.5 مليون دولار لبناء + +308 +00:24:46,260 --> 00:24:50,700 +مدينة ديزني لاند بارك في كاريفوريا، كمثال لتخزين + +309 +00:24:50,700 --> 00:24:56,760 +المالوبالتالي، ديزني افتح مدارس مهمة في أورلاند، + +310 +00:24:56,760 --> 00:25:01,180 +توكيو، باري وفي أكتر مرحلة استثمتت 3.5 مليون لبناء + +311 +00:25:01,180 --> 00:25:06,160 +مدارس مهمة فماذا بالضبط يعني أن الاستثمار المالي + +312 +00:25:06,160 --> 00:25:11,500 +يتضمن استثمارات أصغر أو اختيارات أصغر + +313 +00:25:14,610 --> 00:25:18,990 +هذا لا يعني أنك تقرر خيار كبير، انت فقط تقرر خيار + +314 +00:25:18,990 --> 00:25:22,310 +مرتبط بهذا الموضوع. على سبيل المثال، إذا كنت تقرر + +315 +00:25:22,310 --> 00:25:24,910 +ان تقرر ان تقرر ان تقرر ان تقرر ان تقرر ان تقرر ان + +316 +00:25:24,910 --> 00:25:24,990 +تقرر ان تقرر ان تقرر ان تقرر ان تقرر ان تقرر ان + +317 +00:25:24,990 --> 00:25:25,470 +تقرر ان تقرر ان تقرر ان تقرر ان تقرر ان تقرر ان + +318 +00:25:25,470 --> 00:25:27,910 +تقرر ان تقرر ان تقرر ان تقرر ان تقرر ان تقرر ان + +319 +00:25:27,910 --> 00:25:29,570 +تقرر ان تقرر ان تقرر ان تقرر ان تقرر ان تقرر ان + +320 +00:25:29,570 --> 00:25:36,230 +تقرر ان تقرر ان تقرر ان + +321 +00:25:36,230 --> 00:25:43,200 +تقتقريرات مختلفة في فهم فرصة الاستثمار وانت تفكر + +322 +00:25:43,200 --> 00:25:52,200 +في تقريرات في أفريقيا، في أسيا، في روسيا، في + +323 +00:25:52,200 --> 00:25:56,040 +البلدان المختلفة، لذلك ليس مرتبط بالقرار هذا فقط، + +324 +00:25:56,040 --> 00:26:00,520 +إنه مرتبط بالقرار الوضعي، القرارات التجارية + +325 +00:26:00,520 --> 00:26:04,280 +التجارية مهمة في تصميم نجاح الشركات + +326 +00:26:08,050 --> 00:26:11,090 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +327 +00:26:11,090 --> 00:26:11,690 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +328 +00:26:11,690 --> 00:26:12,210 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +329 +00:26:12,210 --> 00:26:15,490 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +330 +00:26:15,490 --> 00:26:18,930 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +331 +00:26:18,930 --> 00:26:19,670 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +332 +00:26:19,670 --> 00:26:25,510 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +333 +00:26:25,510 --> 00:26:34,390 +عامة عامة عامة + +334 +00:26:34,390 --> 00:26:41,360 +عامة عاملتنشيط رئيسين ناجحين رئيسين ناجحين + +335 +00:26:41,360 --> 00:26:46,600 +يتجاربون جميع مستوى التعامل للعمل لتنشيط الأفكار + +336 +00:26:46,600 --> 00:26:52,500 +لذلك بعد وقت طويل لديهم تجربة جيدة في تنشيط + +337 +00:26:52,500 --> 00:27:01,960 +الأفكار وإستعمال هذه الأفكار طبيعي + +338 +00:27:03,470 --> 00:27:07,230 +البرمجة الكفاءة تحتوي على اتفاقين واثنين وفي بعض + +339 +00:27:07,230 --> 00:27:11,390 +الأثارات الأخرى لدينا اتفاقين في اتفاقين في + +340 +00:27:11,390 --> 00:27:13,270 +اتفاقين اتفاقين في اتفاقين في اتفاقين في اتفاقين + +341 +00:27:13,270 --> 00:27:15,030 +اتفاقين في اتفاقين في اتفاقين في اتفاقين في + +342 +00:27:15,030 --> 00:27:15,250 +اتفاقين في اتفاقين في اتفاقين في اتفاقين في + +343 +00:27:15,250 --> 00:27:16,070 +اتفاقين في اتفاقين في اتفاقين في اتفاقين في + +344 +00:27:16,070 --> 00:27:18,590 +اتفاقين في اتفاقين في اتفاقين في اتفاقWhat are the + +345 +00:27:18,590 --> 00:27:21,790 +promising investment opportunities is important by + +346 +00:27:21,790 --> 00:27:25,510 +consulting the staff, by consulting the external + +347 +00:27:25,510 --> 00:27:28,930 +environment, expertise, consulting the academic + +348 +00:27:28,930 --> 00:27:31,670 +university professors, consulting the government, + +349 +00:27:31,990 --> 00:27:34,610 +consulting all of these people to generate more + +350 +00:27:34,610 --> 00:27:40,270 +ideasالفترة الثانية، قيمة تخلق مميزة للمجارات + +351 +00:27:40,270 --> 00:27:44,210 +المختلفة تم تحقيقها بشكل مستمر، فنحن نتحقق كل هذه + +352 +00:27:44,210 --> 00:27:48,110 +المجارات كما قلت، إذا كان لدينا 100 فكرة، فننتهي + +353 +00:27:48,110 --> 00:27:55,290 +ب3 فكرة، ليس محتاجًا أن نطبق الـ100 فكرة، إذا كان + +354 +00:27:55,290 --> 00:28:03,050 +لدينا 100 فكرة، فننتهي ب3 فكرة، ليس محتاجًا أن + +355 +00:28:03,050 --> 00:28:03,890 +نطبق الـ100 فكرة، إذا كان لدينا 100 فكرة، فنطبق + +356 +00:28:03,890 --> 00:28:04,630 +الـ100 فكرة، إذا كان لدينا 100 فكرة، فنطبق الـ100 + +357 +00:28:04,630 --> 00:28:05,170 +فكرة، إذا كان لدينا 100 فكرة، فنطبق الـ100 فكرة، + +358 +00:28:05,170 --> 00:28:07,700 +إذا كان لدينا 100 فكلأننا نركز على إيقاف + +359 +00:28:07,700 --> 00:28:13,320 +مستخدماتنا المالية، وليس بسهولة أن تجد نفسك نفسك + +360 +00:28:13,320 --> 00:28:14,080 +نفسك نفسك نفسك نفسك نفسك نفسك نفسك نفسك نفسك نفسك + +361 +00:28:14,080 --> 00:28:20,720 +نفسك نفسك نفسك نفسك نفسك نفسك نفسك نفسك نفسك نفسك + +362 +00:28:20,720 --> 00:28:32,380 +نفسك نفسك نفسك نفسك نفسك نفسك نفسك نفسك نفسك + +363 +00:28:33,760 --> 00:28:37,680 +هذا هو السبب في الولايات المتحدة وفي الولايات + +364 +00:28:37,680 --> 00:28:42,260 +المتحدة انهم يتحركوا إلى البيئة التي تحتوي على + +365 +00:28:42,260 --> 00:28:48,480 +تقنيات تقنيات مثل أفريقيا مثل الشرق الأوسط مثل بعض + +366 +00:28:48,480 --> 00:28:53,120 +المكانات في أسيا في بعض المكانات في أستيران + +367 +00:28:53,120 --> 00:28:57,580 +ومقارنات أخرى تقنيات + +368 +00:28:57,580 --> 00:29:05,070 +جيدة تكون أكتر ممكن تجدها في مؤتمرات أقل تقنياتوهي + +369 +00:29:05,070 --> 00:29:08,210 +مجالات المغامرات للمدخل الجديد مرتفعة جدًا لكي + +370 +00:29:08,210 --> 00:29:09,950 +تبقى مختارين + +371 +00:29:13,630 --> 00:29:18,830 +from the place where is the environment with high + +372 +00:29:18,830 --> 00:29:21,270 +competitive to the environment with a low + +373 +00:29:21,270 --> 00:29:24,870 +competitive this is why the business and this is + +374 +00:29:24,870 --> 00:29:27,270 +why the MNC multinational corporations they are + +375 +00:29:27,270 --> 00:29:32,130 +focusing invest in Africa go to the Africa and see + +376 +00:29:32,130 --> 00:29:38,040 +there is cities follow the Chineseنعم، انظروا + +377 +00:29:38,040 --> 00:29:42,060 +لهذه، لديهم مكانين معينة و لديهم كل الشركات و هم + +378 +00:29:42,060 --> 00:29:45,360 +يقومون بالعمل من أفريقيا و إذا كنت تنظر إلى + +379 +00:29:45,360 --> 00:29:51,200 +أفريقيا أيضًا، لديك أشخاص فرنسيين يعملون عملهم لأن + +380 +00:29:51,200 --> 00:29:58,620 +إذا دفعوا المال إلى فرنسا، فرق العودة أقل من ما + +381 +00:29:58,620 --> 00:30:00,760 +يفترض في أفريقيا + +382 +00:30:03,190 --> 00:30:08,850 +النفس الشيء إذا تتكلم عن بعض المكان في إيسيرون، + +383 +00:30:08,850 --> 00:30:14,250 +وهذا هو السبب في اليوم عندما استمتعت للأخبار عن + +384 +00:30:14,250 --> 00:30:18,550 +أوكراين، ان المستخدم الذقني لا يحب أن يتعامل مع + +385 +00:30:18,550 --> 00:30:21,370 +البلدين الأوروبية + +386 +00:30:24,010 --> 00:30:28,110 +لأنهم يريدون أن يحافظوا على المال لأنهم لايرغبون + +387 +00:30:28,110 --> 00:30:31,910 +في الانضمام إلى البلدان الأوروبية لأنهم يخسروا + +388 +00:30:31,910 --> 00:30:34,330 +فرصة المقابلة الأسفة + +389 +00:30:38,650 --> 00:30:42,270 +هذا السبب هنا في باريستان وخاصة في غزا ستريب وويست + +390 +00:30:42,270 --> 00:30:46,970 +بانك انه يشكل من نحو التقديم إذا كنت تنظر إلى + +391 +00:30:46,970 --> 00:30:53,430 +المعاملات التعاملية لدينا فقط شركة واحدة وهي فقط + +392 +00:30:53,430 --> 00:30:58,110 +شركة واحدة في السوق فإذا أفتحنا هذا السوق لشركات + +393 +00:30:58,110 --> 00:31:05,350 +أخرى فسيحصل تفويت من المستخدمين ومن المستخدمين + +394 +00:31:05,350 --> 00:31:07,430 +الخاص بالمستخدمين + +395 +00:31:09,500 --> 00:31:14,520 +لدينا ثلاثة نوعات من المشروعات المالية والأول هو + +396 +00:31:14,520 --> 00:31:18,340 +المشروعات المالية والثانية هي المشروعات التجاربية + +397 +00:31:18,340 --> 00:31:23,320 +والثالثة هي المشروعات المصطلحية والأول هو + +398 +00:31:23,320 --> 00:31:30,700 +المشروعات المالية المشروعات المالية تركز على فرصة + +399 +00:31:30,700 --> 00:31:39,510 +تجارب عاليةعلى سبيل المثال، لديه خطوط صناعة جديدة، + +400 +00:31:39,510 --> 00:31:46,090 +تحضير أجهزة جديدة، تحضير أجهزة جديدة، هذه هي + +401 +00:31:46,090 --> 00:31:50,070 +المشروعات المركزية للتعامل مع المستخدمين الاخر هو + +402 +00:31:50,070 --> 00:31:54,810 +التحدث عن تقسيم الأسعار، فهم يركزون على كيفية + +403 +00:31:54,810 --> 00:31:59,270 +تقسيم الأسعارfor instance they try to replace the + +404 +00:31:59,270 --> 00:32:01,830 +machine, the old machines with the new machines or + +405 +00:32:01,830 --> 00:32:07,310 +they try to see how we can reduce the cost of our + +406 +00:32:07,310 --> 00:32:13,870 +labor or workforce I don't mean here in the cost + +407 +00:32:13,870 --> 00:32:21,170 +reduction that to kick out workersمايعنيه هو تحسين + +408 +00:32:21,170 --> 00:32:25,870 +إيجابية العمليين لإنهم يستطيعوا تقليل أسعارهم + +409 +00:32:25,870 --> 00:32:32,090 +دعونا نأخذ مثال هنا سأعطيك مثال صغير من مجتمعنا + +410 +00:32:32,090 --> 00:32:39,450 +إذا كان لديك مشكلة في هاتفكهو مفتوح و بعدها الـ + +411 +00:32:39,450 --> 00:32:44,310 +Paltel أو الجامعة تطلب منك أن تدعو 199 او 144 انا + +412 +00:32:44,310 --> 00:32:49,410 +لا اعرف نعم 199 او 144 حسنًا PIE 144 نعم يا عزيزي + +413 +00:32:49,410 --> 00:32:53,350 +كيف يمكنني أن أساعدك؟ حسنًا قال لدي مشكلة في حياتي + +414 +00:32:53,350 --> 00:32:59,870 +هذا بلا بلا بلا القصة هي الرجل أو الفتاة المقفلة + +415 +00:32:59,870 --> 00:33:05,370 +في المكان يجيب على هاتفك 24 ساعات الآن هناك مبنى + +416 +00:33:06,590 --> 00:33:10,590 +هذا المبنى يمكن أن يكون شرحه بالبالتين، فالبالتين + +417 +00:33:10,590 --> 00:33:14,850 +يدفعون الشرح و يدفعون الضوء و يدفعون الحماية و + +418 +00:33:14,850 --> 00:33:21,050 +يدفعون كل شيء لهذا الرجل أو هذه الفتاة. كيف نقدر + +419 +00:33:21,050 --> 00:33:25,690 +أن نقل الأسعار؟ بعض الناس يعتقدون أن نقل الأسعار + +420 +00:33:25,690 --> 00:33:31,530 +هو فقط إخراج أو تقليل عدد العاملين، لا شيء يتحرك + +421 +00:33:31,530 --> 00:33:38,040 +هكذاOkay okay that's fine what the idea if you are + +422 +00:33:38,040 --> 00:33:42,360 +working home so we cannot pay your bill we cannot + +423 +00:33:42,360 --> 00:33:45,820 +pay for your security we cannot pay you for your + +424 +00:33:45,820 --> 00:33:50,780 +light so we can like save a lot of money of doing + +425 +00:33:50,780 --> 00:33:54,860 +this for instance in the UK if you have a problem + +426 +00:33:54,860 --> 00:34:00,520 +in your landline you just dial 144 hi someone in + +427 +00:34:00,520 --> 00:34:04,880 +India is answering your phoneوالذي يجلس مع أطفاله + +428 +00:34:04,880 --> 00:34:09,420 +وعائلته ويجيب على اتصالك وانه او انها تتعامل مع + +429 +00:34:09,420 --> 00:34:14,200 +اتصالك بطريقة مفيدة، فهذا مثل أننا نقوم بتقلي + +430 +00:34:14,200 --> 00:34:19,410 +الcostلماذا يجب أن يبقى هذا الرجل أو الفتاة في + +431 +00:34:19,410 --> 00:34:26,170 +المبنى؟ هو مثلًا مقفل في المبنى و يشربه بالكافي و + +432 +00:34:26,170 --> 00:34:32,010 +بالطي و بالضوء و بالأمان و بالسيارة و بكل شيء فقط + +433 +00:34:32,010 --> 00:34:36,530 +يا عزيزي أبقى في منزلك و أفعل عملك في المنزل فماذا + +434 +00:34:36,530 --> 00:34:41,170 +بالضبط فعلنا هو أننا نقوم بإنقاذ الأسعار ولكننا + +435 +00:34:41,170 --> 00:34:46,740 +يجب أن ندرس هؤلاء الناس على فعل هذاOkay، so this + +436 +00:34:46,740 --> 00:34:49,100 +is what I mean cost reduction investments + +437 +00:34:49,100 --> 00:34:52,380 +Mandatory + +438 +00:34:52,380 --> 00:34:57,480 +investments sometimes the government asking the + +439 +00:34:57,480 --> 00:35:03,580 +businesses to have investments related to the for + +440 +00:35:03,580 --> 00:35:06,500 +instance to the greenpeacerelated to the + +441 +00:35:06,500 --> 00:35:10,160 +environment this is neither revenue enhancing + +442 +00:35:10,160 --> 00:35:14,840 +projects nor cost reduction so it's related to the + +443 +00:35:14,840 --> 00:35:18,580 +environment let's say for instance here in the IOG + +444 +00:35:18,580 --> 00:35:21,120 +if the government is coming to say look how many + +445 +00:35:21,120 --> 00:35:25,740 +students that we have we have 25 students okay see + +446 +00:35:25,740 --> 00:35:33,050 +each student should have one meter squaredالحكومة + +447 +00:35:33,050 --> 00:35:37,430 +تقول بسبب أن هذه الأشياء المحيطية، كل طلاب يملك 1 + +448 +00:35:37,430 --> 00:35:41,150 +متر مكسور، لذلك الآن الشركة الشرقية يجب أن تفكر، + +449 +00:35:41,150 --> 00:35:46,250 +حسنا دعنا نريد أن نحصل على أكتر أرض، هذا ليس مرتبط + +450 +00:35:46,250 --> 00:35:50,350 +بالتحسين الدولي أو تحسين الأسعار، إنه مرتبط + +451 +00:35:50,350 --> 00:35:52,370 +بالحكومات التي تتبعها الحكومات + +452 +00:35:55,250 --> 00:36:03,290 +على سبيل المثال، إذا كان لدينا مصنع في الجبهة، على + +453 +00:36:03,290 --> 00:36:06,830 +سبيل المثال، وقامت بالتحرير، فسيطلب الحكومة أن + +454 +00:36:06,830 --> 00:36:12,030 +تقوم باستثناء لمنطقة المجتمع، فهذا مرتبط + +455 +00:36:12,030 --> 00:36:13,770 +بالاستثناء المجلد + +456 +00:36:20,380 --> 00:36:24,300 +قبل أن يكون هناك إبتكار ، الفيرم يريد أن يتأكد من + +457 +00:36:24,300 --> 00:36:29,580 +أنه سيخلق قيمة قبل أن تبدأ عملك عملك عليك أن تقرر + +458 +00:36:29,580 --> 00:36:35,840 +كيف يتأثر على قيمة الفيرم لتحرير احتمالية أو + +459 +00:36:35,840 --> 00:36:39,900 +استفادة من اقتراحات الاستثمار نستطيع استخدام عديد + +460 +00:36:39,900 --> 00:36:42,660 +من الأدوات التعليمية مثل Net Present Value + +461 +00:36:42,660 --> 00:36:47,000 +وEquivalent Annual Costالنسبة للأسعار هي أنهم + +462 +00:36:47,000 --> 00:36:49,440 +يدفعوا عمل إعادة إعادة و يقوموا بإعادة إعادة و + +463 +00:36:49,440 --> 00:36:50,360 +يقوموا بإعادة و يقوموا بإعادة و يقوموا بإعادة و + +464 +00:36:50,360 --> 00:36:53,320 +يقوموا بإعادة و يقوموا بإعادة و يقوموا بإعادة و + +465 +00:36:53,320 --> 00:36:54,920 +يقوموا بإعادة و يقوموا بإعادة و يقوموا بإعادة و + +466 +00:36:54,920 --> 00:36:56,320 +يقوموا بإعادة و يقوموا بإعادة و يقوموا بإعادة و + +467 +00:36:56,320 --> 00:36:57,400 +يقوموا بإعادة و يقوموا بإعادة و يقوموا بإعادة و + +468 +00:36:57,400 --> 00:37:02,160 +يقوموا بإعادة و يقوموا بإعادة و يقوموا بإعادة و ي + diff --git a/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/UtzTTGLnfWY.srt b/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/UtzTTGLnfWY.srt new file mode 100644 index 0000000000000000000000000000000000000000..031ad57c55a7a81cb5046cac82f496998ec44ea6 --- /dev/null +++ b/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/UtzTTGLnfWY.srt @@ -0,0 +1,1987 @@ +1 +00:00:20,200 --> 00:00:22,920 +بسم الله الرحمن الرحيم، as I said in the first + +2 +00:00:22,920 --> 00:00:27,600 +five minutes, we hope you did enjoy the weekend + +3 +00:00:27,600 --> 00:00:35,900 +and you read around the finance and just + +4 +00:00:35,900 --> 00:00:38,940 +to summarize what I said in the previous meeting, + +5 +00:00:40,440 --> 00:00:43,860 +we talked about your course plan, the importance + +6 +00:00:43,860 --> 00:00:47,500 +of your course plan and to commit to this course + +7 +00:00:47,500 --> 00:00:55,180 +plan، ومهمة الانبعاث الانبعاث عامة تركز على ثلاث + +8 +00:00:55,180 --> 00:01:02,520 +أشياء أو ثلاث قرارات. أول قرار مرتبط بالـ Capital + +9 +00:01:02,520 --> 00:01:08,680 +Budgeting. كيف نستخدم قطعنا؟ و فقط لأذكركم عندما + +10 +00:01:08,680 --> 00:01:16,160 +أتكلم عن هذا هو موقع T وقد قمنا بالقرصين هنا هو + +11 +00:01:16,160 --> 00:01:22,070 +Capital Budgeting أو في بعض الأحيان نسميها كبيتال + +12 +00:01:22,070 --> 00:01:30,050 +إكسبنتور. وهذه هي أسلوب الكبيتل، وهذه + +13 +00:01:30,050 --> 00:01:33,610 +هي القرار الأول يجب أن نأخذه، وهذه القرار الثاني في + +14 +00:01:33,610 --> 00:01:38,590 +الواقع. ومن ثم كيف نجمع هذه المنطقة من هذه المنطقة، + +15 +00:01:38,590 --> 00:01:43,590 +هذه هي القرارات الثلاثة، ونعتبر هذه القرارات قرارات + +16 +00:01:43,590 --> 00:01:53,230 +طويلة المدى. قرارات لماذا أنا أتكلم عن هذه المنطقة؟ + +17 +00:01:53,230 --> 00:01:58,290 +لأنها مرتبطة بالاختيارات الإقصائية ومرتبطة + +18 +00:01:58,290 --> 00:02:02,470 +بالمال. التواصل التواصل + +19 +00:02:02,470 --> 00:02:05,450 +التواصل التواصل التواصل التواصل التواصل التواصل + +20 +00:02:05,450 --> 00:02:05,690 +التواصل التواصل التواصل التواصل التواصل التواصل + +21 +00:02:05,690 --> 00:02:05,830 +التواصل التواصل التواصل التواصل التواصل التواصل + +22 +00:02:05,830 --> 00:02:06,450 +التواصل التواصل التواصل التواصل التواصل التواصل + +23 +00:02:06,450 --> 00:02:07,950 +التواصل التواصل التواصل التواصل التواصل التواصل + +24 +00:02:07,950 --> 00:02:09,130 +التواصل التواصل التواصل التواصل التواصل التواصل + +25 +00:02:09,130 --> 00:02:11,690 +التواصل التواصل التواصل التواصل التواصل التواصل + +26 +00:02:11,690 --> 00:02:17,510 +التواصل. والأهم من الانبعاث هو كيف تتعامل مع + +27 +00:02:17,510 --> 00:02:21,070 +الانبعاث الكفائية وكيف تتعامل مع الانبعاث الكفائية + +28 +00:02:21,070 --> 00:02:26,830 +وكيف تتعامل مع الانبعاث بينهم الآن. + +29 +00:02:26,830 --> 00:02:33,310 +لماذا ندرس الانبعاث؟ ندرس الانبعاث. لماذا ندرس + +30 +00:02:33,310 --> 00:02:38,130 +الانبعاث؟ هل مهم أن ندرس الانبعاث؟ هل مهم؟ نعم. + +31 +00:02:38,130 --> 00:02:40,970 +لماذا نعم؟ أو لو لا؟ لماذا لا؟ لماذا لا؟ + +32 +00:02:45,400 --> 00:02:50,480 +قالوا يجب أن تعملوا قرار جيد يتعلق بماذا؟ قراراتك، + +33 +00:02:50,480 --> 00:02:59,080 +قراراتك ماذا؟ قرارات حياة شخصية، حياة عالمية، حياة + +34 +00:02:59,080 --> 00:02:59,880 +مشروعية، حياة مشروعية، حياة مشروعية، حياة مشروعية، + +35 +00:02:59,880 --> 00:03:01,460 +حياة مشروعية، حياة مشروعية، حياة مشروعية، حياة + +36 +00:03:01,460 --> 00:03:02,100 +مشروعية، حياة مشروعية، حياة مشروعية، حياة مشروعية، + +37 +00:03:02,100 --> 00:03:02,520 +حياة مشروعية، حياة مشروعية، حياة مشروعية، حياة + +38 +00:03:02,520 --> 00:03:03,500 +مشروعية، حياة مشروعية، حياة مشروعية، حياة مشروعية، + +39 +00:03:03,500 --> 00:03:08,180 +حياة مشروعية، حياة مشروعية، حياة مشروdecisions + +40 +00:03:08,180 --> 00:03:12,420 +sometimes hard decisions in terms of your personal + +41 +00:03:12,420 --> 00:03:16,660 +life. buying a house or not buying a house. buying a + +42 +00:03:16,660 --> 00:03:19,740 +car or not buying a car. joining the college or not + +43 +00:03:19,740 --> 00:03:22,240 +joining the college. taking the degree or not + +44 +00:03:22,240 --> 00:03:25,780 +taking the degree. This is the financial decisions + +45 +00:03:25,780 --> 00:03:31,240 +influence on your life. So if you don't have a + +46 +00:03:31,240 --> 00:03:36,680 +knowledge on how finance is important in your life + +47 +00:03:36,680 --> 00:03:41,400 +so you may end up with the wrong decision. This is + +48 +00:03:41,400 --> 00:03:46,040 +from the personal point of view. في نظر المهندس، + +49 +00:03:46,040 --> 00:03:51,500 +يعني كما قالت، من الواقع الواقعي للشركات، للعمل، + +50 +00:03:51,500 --> 00:03:58,240 +العمل مضمون لاختيار خيارات اقتصادية لأن تأثيرها + +51 +00:03:58,240 --> 00:04:03,160 +على استراتيجية العمل، تأثيرها على نظرها، قيمها + +52 +00:04:03,160 --> 00:04:11,800 +ومهمة العمل، لهذا السبب هي ... هي مهمة Finance, the + +53 +00:04:11,800 --> 00:04:14,960 +importance of finance, finance is like integral + +54 +00:04:14,960 --> 00:04:18,820 +part of all aspects of business. We have + +55 +00:04:18,820 --> 00:04:24,120 +marketing, we have production, we have marketing + +56 +00:04:24,120 --> 00:04:30,600 +mix, we have IT departments, finance intervene in + +57 +00:04:30,600 --> 00:04:34,990 +all business aspects, so as integral part. هذا هو + +58 +00:04:34,990 --> 00:04:39,810 +المهم في التخلص، لذلك لدينا الكثير من الأمثلة عن + +59 +00:04:39,810 --> 00:04:45,430 +الاختيارات التخلصية، هل يمكنك أن تعطيني أمثلة + +60 +00:04:45,430 --> 00:04:51,370 +لحياة مشروعية، لعمل، اختيارات تخلصية؟ كما قلت، في + +61 +00:04:51,370 --> 00:04:54,930 +حياة شخصية، تشتري منزل أو لا تشتري منزل، ولكن + +62 +00:04:54,930 --> 00:05:00,270 +لعمل، ماهي خيارات التخلص يجب أن تأخذ العمل ويكون + +63 +00:05:00,270 --> 00:05:06,060 +لديه جانب تخلصي؟ Yes. Opening, opening new branches. + +64 +00:05:06,060 --> 00:05:14,760 +Closing old branches. Hiring or + +65 +00:05:14,760 --> 00:05:19,580 +firing. Hiring employees or firing employees. Yes. + +66 +00:05:19,580 --> 00:05:27,100 +Buying machines or not buying machines. Yes. + +67 +00:05:27,100 --> 00:05:33,690 +Yeah. Invest in the inventory. هو قرار اقتصادي؟ لماذا + +68 +00:05:33,690 --> 00:05:38,890 +هو قرار اقتصادي؟ لماذا هو قرار اقتصادي؟ كما قالت + +69 +00:05:38,890 --> 00:05:43,270 +بيشتغل أسلوب أو لا بيشتغل أسلوب. لماذا هو قرار + +70 +00:05:43,270 --> 00:05:52,030 +اقتصادي؟ هل هذا مرتبط بالتعامل بأسلوب Fixed؟ لماذا + +71 +00:05:52,030 --> 00:05:55,970 +هو قرار اقتصادي؟ + +72 +00:05:55,970 --> 00:06:03,300 +نعم. هل هذا يتأثر على ميكروفت أو كيبوتين؟ Okay, it + +73 +00:06:03,300 --> 00:06:10,820 +could be. Yes, you're right. Yes. + +74 +00:06:10,820 --> 00:06:14,300 +You're + +75 +00:06:14,300 --> 00:06:19,780 +right. Yeah. Anything else? Because at the end of the + +76 +00:06:19,780 --> 00:06:24,900 +day you have to pay money. Yes, you have to pay + +77 +00:06:24,900 --> 00:06:30,250 +money. So listen here, just to differentiate between + +78 +00:06:30,250 --> 00:06:35,150 +finance and other aspects of business. نحن لدينا + +79 +00:06:35,150 --> 00:06:39,770 +أسباب أساسية أساسية تلقى رقمين في الشبكة الاقتصادي + +80 +00:06:39,770 --> 00:06:47,170 +والاستخدام. كما قلت اقتصادي اشتراء واستخدام لديه + +81 +00:06:47,170 --> 00:06:52,450 +سلسلة هي أشياء اقتصادية. ما هي الجزء الاقتصادي من + +82 +00:06:52,450 --> 00:06:57,710 +شراء هذه السلسلة؟ كم ينتج هذه السلسلة؟ هذا خيار + +83 +00:06:57,710 --> 00:07:03,680 +اقتصادي جدًا. القرار المالي هو الجزء المالي من + +84 +00:07:03,680 --> 00:07:06,680 +القرار المالي لأنه في نهاية اليوم علينا أن ندفع + +85 +00:07:06,680 --> 00:07:13,440 +المال لتشتري هذه السيارة. التعامل التعامل هو تسجيل + +86 +00:07:13,440 --> 00:07:20,020 +التجارب. تسجيل السيارة في المقالات أو في المقالات + +87 +00:07:20,020 --> 00:07:25,630 +هو التعامل. تأخذ القرار نفسه هو القرار المالي. ماذا + +88 +00:07:25,630 --> 00:07:31,630 +سندفع للهاتف؟ وإذا لم ندفع للهاتف، ما هي + +89 +00:07:31,630 --> 00:07:36,750 +الاختيارات الأخرى؟ لهذا السبب خطوة صغيرة بين + +90 +00:07:36,750 --> 00:07:41,130 +الأشياء الاقتصادية والأشياء التخزينية، التخزينية + +91 +00:07:41,130 --> 00:07:47,300 +بالنسبة لإختيار القرار. الشركة تنتج وهي تحتوي على + +92 +00:07:47,300 --> 00:07:51,260 +اقتصاد مستوى وقيمة اقتصادية. ولكن المشكلة هي أن + +93 +00:07:51,260 --> 00:07:57,640 +الاختيار الأساسي يأتي ويقول ما هي الـ E. كل يوم في + +94 +00:07:57,640 --> 00:08:01,020 +حياة العمل يجب أن نأخذ بعض الاختيارات الأساسية في + +95 +00:08:01,020 --> 00:08:06,910 +مجموعة قصيرة وفي مجموعة طويلة. هي as some examples + +96 +00:08:06,910 --> 00:08:09,470 +هي how will general motors. This is a stand for + +97 +00:08:09,470 --> 00:08:13,170 +general motors. A strategic decision to invest 740 + +98 +00:08:13,170 --> 00:08:16,310 +million dollars to produce Chevy Volt require the + +99 +00:08:16,310 --> 00:08:19,530 +expertise of different disciplines within the + +100 +00:08:19,530 --> 00:08:23,650 +business school such as marketing, management, + +101 +00:08:24,070 --> 00:08:27,290 +accounting, operations, management and finance. + +102 +00:08:28,810 --> 00:08:37,290 +والخدمة تعمل في كل هذه الأشياء والخدمة + +103 +00:08:37,290 --> 00:08:40,250 +تحتاج إلى المعرفة تحتاج إلى الأدوات. إذا كنت تعود + +104 +00:08:40,250 --> 00:08:44,090 +إلى الصفحات السابقة، إذا كنت تنظر إلى هنا معرفة + +105 +00:08:44,090 --> 00:08:49,530 +الأدوات المالية. دعونا نعود إلى السؤال الشخصي عن + +106 +00:08:49,530 --> 00:08:55,080 +شراء منزل أو لا شراء منزل. نحن يجب أن نكون معروفين + +107 +00:08:55,080 --> 00:09:03,340 +من أدوات التمويل. حسنًا، اشتري منزل إذا + +108 +00:09:03,340 --> 00:09:09,320 +قررت أو قد قررت أن تشتري منزل الأن الان التمويل + +109 +00:09:09,320 --> 00:09:16,740 +يأتي ويسألك كيف ستشتري منزل. التمويل + +110 +00:09:18,780 --> 00:09:22,380 +إذا كانت المنزل 100 ألف دولار على سبيل المثال + +111 +00:09:22,380 --> 00:09:25,780 +وكانت لديك 100 ألف دولار، لذا يمكنك أن تأخذ القرار + +112 +00:09:25,780 --> 00:09:31,000 +يمكنك أن تأخذ القرار، حسنا؟ لذا يمكنك أن تأخذ + +113 +00:09:31,000 --> 00:09:38,040 +القرار. ولكن بعض الأحيان لديك 100 ألف دولار، ولكن + +114 +00:09:38,040 --> 00:09:42,780 +تفكر لماذا يجب أن أشتري المنزل من مالي؟ لذا حسنًا + +115 +00:09:42,780 --> 00:09:48,830 +سأشتري 50 ألف دولار من 100,000 دعوة، وبعدها تدفع + +116 +00:09:48,830 --> 00:09:55,230 +الأخرى من البنك. لذلك يجب أن تعرف الأدوات، يجب أن + +117 +00:09:55,230 --> 00:09:59,190 +تكون لديك قليل من التجربة من مستوى الشخصي. ماذا هي + +118 +00:09:59,190 --> 00:10:02,890 +قيمة التمويل المقتصرة من البنك؟ هذا في مستوى + +119 +00:10:02,890 --> 00:10:11,980 +الشخصي. هذا مثال صغير. إذا لم تكن لديك مال في صندوقك + +120 +00:10:11,980 --> 00:10:18,040 +، لذلك تبدأ بـ 0 دولار أو تستخدم 0 دولار. ما هي + +121 +00:10:18,040 --> 00:10:23,500 +التغييرات؟ لذلك يجب أن تفكر بطريقات مختلفة في + +122 +00:10:23,500 --> 00:10:30,440 +التفكير في الحصول على محافظة محافظة محافظة محافظة + +123 +00:10:30,440 --> 00:10:35,260 +محافظة محافظة محافظة محافظة محافظة محافظة محافظة + +124 +00:10:35,260 --> 00:10:38,320 +محافظة محافظة محافظة محافظة محافظة محافظة محافظة + +125 +00:10:38,320 --> 00:10:38,780 +محافظة محافظة محافظة محافظة محافظة محافظة محافظة + +126 +00:10:38,780 --> 00:10:38,840 +محافظة محافظة محافظة محافظة محافظة محافظة محاف + +127 +00:10:39,490 --> 00:10:45,930 +العلم الخاص بالتمويل مهم، هذا في مستوى شخصيك، وإذا + +128 +00:10:45,930 --> 00:10:50,370 +كنا نتكلم عن مستوى الشركة ومستوى العمل، فهناك علم + +129 +00:10:50,370 --> 00:10:53,790 +كبير، ويجب أن تكون هناك علم كبير في فهم أدوات + +130 +00:10:53,790 --> 00:11:00,890 +التمويل، لماذا هو العلم؟ العلم .. الفرق بين العلم + +131 +00:11:00,890 --> 00:11:09,420 +هو أن العلم يأتي من البيانات. وهذه هي المعرفة + +132 +00:11:13,920 --> 00:11:22,240 +العلم هو كيف تقرر البيانات وكيف تفهمها. أعرف أن + +133 +00:11:22,240 --> 00:11:26,760 +هناك دولة مفتوحة المواجهة مفتوحة والأشياء الأخرى + +134 +00:11:26,760 --> 00:11:32,020 +المالية مفتوحة. لكن كيف تقررها؟ الطريقة التي تقوم + +135 +00:11:32,020 --> 00:11:35,680 +بتجارب هذه التغييرات في عقلكم وتقوم بتأخير المعرفة + +136 +00:11:35,680 --> 00:11:40,060 +أو تقررها. بعض الناس فقط يدخلوا أشياء في عقلهم ولا + +137 +00:11:40,060 --> 00:11:44,640 +يعرفون كيف تستخدم هذه البيانات. ومن الممكن أنهم لا + +138 +00:11:44,640 --> 00:11:49,240 +يستخدموا هذه الأدوات لتأخذ اختياراتهم الشخصية، + +139 +00:11:49,240 --> 00:11:52,620 +إنهم يعرفون أن هذه الأدوات متوفرة، والمعارف + +140 +00:11:52,620 --> 00:11:55,040 +متوفرة، والمعارف متوفرة، ومعارفات متوفرة، + +141 +00:11:55,040 --> 00:11:55,140 +ومعارفات متوفرة، ومعارفات متوفرة، ومعارفات متوفرة، + +142 +00:11:55,140 --> 00:11:55,660 +ومعارفات متوفرة، ومعارفات متوفرة، ومعارفات متوفرة، + +143 +00:11:55,660 --> 00:11:56,860 +ومعارفات متوفرة، ومعارفات متوفرة، ومعارفات متوفرة، + +144 +00:11:56,860 --> 00:12:02,900 +ومعارفات متوفرة، ومعارفات متوفرة، ومعارفات + +145 +00:12:03,850 --> 00:12:06,970 +الذين ليسوا معروفين من الناس الذين + +146 +00:12:06,970 --> 00:12:10,710 +يستخدمون رأسهم في الاختيارات، ونفس الشيء بالنسبة + +147 +00:12:10,710 --> 00:12:15,270 +للحياة المستخدمة، لذلك الكثير من الاختيارات + +148 +00:12:15,270 --> 00:12:20,370 +البشرية يتطلبون معرفة اقتصادية، + +149 +00:12:20,370 --> 00:12:24,870 +على سبيل المثال، شرح منزل، شراء سيارة وكذلك + +150 +00:12:24,870 --> 00:12:30,410 +وكذلك بدلاً من شرح منزل، يمكنك شرح منزل على سبيل + +151 +00:12:30,410 --> 00:12:34,110 +المثال إذا تتكلم في بعض الأماكن في دبي على سبيل + +152 +00:12:34,110 --> 00:12:40,710 +المثال إذا كنت تتخيل شراء منزل أو بناء منزل، بناء + +153 +00:12:40,710 --> 00:12:45,750 +منزل هو أغلى من شراء منزل، نعم إذا كنت تتكلم في + +154 +00:12:45,750 --> 00:12:49,610 +لندن على سبيل المثال، بناء منزل هو أغلى من شراء + +155 +00:12:49,610 --> 00:12:50,170 +منزل + +156 +00:12:54,220 --> 00:12:57,480 +القرار الصحيح عندما تقول حسنًا، بيع المنزل هو + +157 +00:12:57,480 --> 00:13:01,960 +القرار الأفضل، لا أحيانًا الحياة لا تتحرك مثل هذا + +158 +00:13:01,960 --> 00:13:08,800 +لذلك في النهاية يجب أن تكون لديك المعرفة بثلاثة + +159 +00:13:08,800 --> 00:13:13,000 +أشكال مؤسسات، نتحدث + +160 +00:13:13,000 --> 00:13:18,660 +عن حياة شخصية، سنتحدث عن حياة مصرفية أو حياة مؤسسة + +161 +00:13:19,720 --> 00:13:29,120 +بشكل عام مؤسسات موجودة في ثلاثة، شركات مؤسسات + +162 +00:13:29,120 --> 00:13:31,960 +مؤسسات مؤسسات مؤسسات مؤسسات مؤسسات مؤسسات مؤسسات + +163 +00:13:31,960 --> 00:13:32,020 +مؤسسات مؤسسات مؤسسات مؤسسات مؤسسات مؤسسات مؤسسات + +164 +00:13:32,020 --> 00:13:33,940 +مؤسسات مؤسسات مؤسسات مؤسسات مؤسسات مؤسسات مؤسسات + +165 +00:13:33,940 --> 00:13:35,940 +مؤسسات مؤسسات مؤسسات مؤسسات مؤسسات مؤسسات مؤسسات + +166 +00:13:35,940 --> 00:13:37,560 +مؤسسات مؤسسات مؤسسات مؤسسات مؤسسات مؤسسات مؤسسات + +167 +00:13:37,560 --> 00:13:44,340 +مؤسسات مؤسسات مؤسسات مؤسسات م + +168 +00:13:49,150 --> 00:13:55,230 +the managers between two to five or more, two or + +169 +00:13:55,230 --> 00:14:02,650 +more corporations, many many managers manage the + +170 +00:14:02,650 --> 00:14:07,970 +company, okay, raise your voice, أعلى صوتك again, yes + +171 +00:14:07,970 --> 00:14:12,550 +no no just carry on, okay, carry on بقى just raise + +172 +00:14:12,550 --> 00:14:17,900 +your voice، the sole company for managers is only one + +173 +00:14:17,900 --> 00:14:22,980 +person؟ managers or owners? owners, because we + +174 +00:14:22,980 --> 00:14:27,540 +managers are related to the corporations, okay, + +175 +00:14:27,540 --> 00:14:32,180 +corporations and owners are two or more and they + +176 +00:14:32,180 --> 00:14:33,180 +are partnerships + +177 +00:14:36,670 --> 00:14:40,850 +more than ... okay, public, okay, so what other things + +178 +00:14:40,850 --> 00:14:43,810 +what other differences between the sole + +179 +00:14:43,810 --> 00:14:49,750 +proprietorship the partners and from + +180 +00:14:49,750 --> 00:14:54,130 +the capital, okay, raise your voice please + +181 +00:14:54,130 --> 00:14:58,510 +proprietorship + +182 +00:15:00,630 --> 00:15:07,190 +أسعارها أقل من المشاركة، ومشاركتها أقل من الشركات + +183 +00:15:07,190 --> 00:15:16,570 +هل تفكرين لماذا؟ لماذا الشركة أعلى في الشركات؟ هذا + +184 +00:15:16,570 --> 00:15:21,870 +واحد من الأشياء الرئيسية، المشاركات أعلى في الشركات + +185 +00:15:21,870 --> 00:15:25,950 +وليس في المشاركات ومشاركتها + +186 +00:15:32,180 --> 00:15:39,120 +Okay, could be, yeah, this area here, yes, the events + +187 +00:15:39,120 --> 00:15:43,200 +also on the liability of the types of + +188 +00:15:43,200 --> 00:15:46,500 +organizations, and we saw in the partnership and in + +189 +00:15:46,500 --> 00:15:49,680 +the partnership there are limited liability for + +190 +00:15:49,680 --> 00:15:52,300 +yeah, this is one of the main differences, but for + +191 +00:15:52,300 --> 00:15:54,980 +the corporation it's unlimited, it depends on how + +192 +00:15:54,980 --> 00:16:01,000 +much they invest, unlimited, are you sure على + +193 +00:16:01,000 --> 00:16:06,600 +المقاومة، نعم، دعونا نعود إلى الـ .. أنت محقة عندما + +194 +00:16:06,600 --> 00:16:13,320 +تقولين على المقاومة، لماذا الكابيتل أكبر في حالة + +195 +00:16:13,320 --> 00:16:18,900 +الشركات؟ لأنها بسيطة جدًا، إذا كان لدينا مثلًا أنا + +196 +00:16:18,900 --> 00:16:24,280 +أذهب للبنك وأسأل عن قرض، وأنا لدي مقاومة مثلًا وهي + +197 +00:16:24,280 --> 00:16:32,660 +مثلًا ممثل الشركة السعودية، وإذا بالتل يذهب للبنك، + +198 +00:16:32,660 --> 00:16:38,080 +فماذا تعتقدين؟ البنك يعطي بالتل أكثر مني أو أنا أكثر + +199 +00:16:38,080 --> 00:16:42,220 +من بالتل؟ بالتل بالتل بالتل بالطبع، لأن البنك يثق + +200 +00:16:42,220 --> 00:16:49,650 +بالتل أكثر مني لأنها شركة عامة، they recover their + +201 +00:16:49,650 --> 00:16:53,910 +debt easily، بقى me I may have risk بقبولهم، they + +202 +00:16:53,910 --> 00:16:58,830 +may not have risk، this is the issues، one thing is + +203 +00:16:58,830 --> 00:17:01,930 +more honors، the second thing is the trust or the + +204 +00:17:01,930 --> 00:17:09,940 +credibility، القدرات القدرات الشركات أكبر من القدرات + +205 +00:17:09,940 --> 00:17:15,840 +الناس أو القدرات الشركات الإدارية والمفاتيح على + +206 +00:17:15,840 --> 00:17:21,760 +سبيل المثال، إذا مات هذا الرجل، فمن سيحفظ القدرات؟ + +207 +00:17:24,360 --> 00:17:28,580 +يجب أن نسميها الانهيارات، وتفعل الأشياء، وتأخذ + +208 +00:17:28,580 --> 00:17:33,160 +الاختصارات القانونية، ولكن بالنسبة للشركات، إذا + +209 +00:17:33,160 --> 00:17:38,260 +مديرها ماتت، ليس هذا مشكلة كبيرة، هناك أشخاص آخرين + +210 +00:17:38,260 --> 00:17:42,580 +يستطيعون أو الشركة نفسها هي المسؤولة عن إعادة + +211 +00:17:42,580 --> 00:17:48,340 +قدراتها، حسنًا؟ فالرغم من ذلك، ما هي أشياء أخرى أو + +212 +00:17:48,340 --> 00:17:52,970 +اختلافات أخرى بين، There is more conflict and + +213 +00:17:52,970 --> 00:17:59,990 +overlap in the corporation. I like what you said. + +214 +00:18:00,390 --> 00:18:01,410 +What they call this? + +215 +00:18:05,770 --> 00:18:13,030 +هذا التعارض بين من ومن؟ دعنا نتحمل في هذا + +216 +00:18:13,030 --> 00:18:15,810 +الموضوع، لا تتحرك في هذا الموضوع، فقط في هذا + +217 +00:18:15,810 --> 00:18:20,970 +الموضوع، التعارض بين من؟ بين من؟ بين الرئيسين + +218 +00:18:20,970 --> 00:18:27,450 +والمعاملين، هذا ما يسمونه مشكلة الشركة، هناك مشكلة + +219 +00:18:27,450 --> 00:18:31,250 +تسمى مشكلة الشركة، هل تعرفين مشكلة الشركة؟ + +220 +00:18:36,570 --> 00:18:40,250 +Okay, we will go back, just write this down in your + +221 +00:18:40,250 --> 00:18:42,890 +margin, then we will go back. This is not the time + +222 +00:18:42,890 --> 00:18:46,550 +to talk about this، Okay, what what do you think? + +223 +00:18:48,370 --> 00:18:57,070 +Say it again، Yes, yeah is limited or unlimited، In + +224 +00:18:57,070 --> 00:19:03,170 +the corporations is unlimited، Is limited، Yeah, + +225 +00:19:03,350 --> 00:19:08,470 +yeah, you're right. So as as she said، السنة الحياة + +226 +00:19:08,470 --> 00:19:15,550 +للعمل بالنسبة للمؤسسات هي غير محددة، ولكن في الـ .. + +227 +00:19:15,550 --> 00:19:20,010 +في الـ .. مؤسسات ومشاركتها الوحيدة هي محددة، دعونا + +228 +00:19:20,010 --> 00:19:21,890 +نرى على سبيل المثال، هل يمكنك أن تعطينا مثال عن + +229 +00:19:21,890 --> 00:19:25,350 +مؤسسة ومشاركتها الوحيدة؟ هنا، من حياتك الحقيقية + +230 +00:19:25,350 --> 00:19:31,550 +ماركتين، ميني ماركتين، هل يمكنك أن تتذكر على سبيل + +231 +00:19:42,720 --> 00:19:49,020 +عندما كانت الجزيرة محطمة في الحرب؟ في أي موقع؟ + +232 +00:20:03,180 --> 00:20:09,980 +لما صار الحرب القصة، فخسر صاحب المطعم، ومارجعش and + +233 +00:20:09,980 --> 00:20:13,660 +closed down، any example from your tiny streets + +234 +00:20:13,660 --> 00:20:20,220 +just an example، just go back in your before 15 + +235 +00:20:20,220 --> 00:20:24,280 +years and just flashing back، remember some stores + +236 +00:20:24,280 --> 00:20:28,340 +some shops and closed down، did you remember this، I + +237 +00:20:28,340 --> 00:20:34,880 +remember many of them، I remember many of them، ممكن + +238 +00:20:34,880 --> 00:20:38,960 +يكون واحد selling Falafel for instance، this is + +239 +00:20:38,960 --> 00:20:41,840 +sole proprietorship and closed down because the + +240 +00:20:41,840 --> 00:20:45,240 +man is died، because sometimes a conflict between + +241 +00:20:45,240 --> 00:20:49,600 +the partners for instance X and his wife، X and his + +242 +00:20:49,600 --> 00:20:55,820 +sons، X and his cousins، this is examples of the + +243 +00:20:55,820 --> 00:21:04,260 +partnerships، but as as she said، الشركات لديها حياة + +244 +00:21:04,260 --> 00:21:07,360 +أكثر، هل يمكنك أن تعطي أمثلة لشركات لديها أكثر من + +245 +00:21:07,360 --> 00:21:13,020 +100 سنة؟ نعم، هل يمكنك أن تعطي أمثلة لشركات لديها + +246 +00:21:13,020 --> 00:21:19,900 +أكثر من 100 سنة؟ ماذا هذا؟ فقط 40 سنة، لا لا، أكثر + +247 +00:21:19,900 --> 00:21:26,100 +من 100 سنة، هل أنتي متأكدة؟ أنت مجدد الـ 80s، 1800 + +248 +00:21:26,100 --> 00:21:32,750 +شيء فقط، تذكر شركة معينة، Okay, I will give you a + +249 +00:21:32,750 --> 00:21:38,190 +company، Coca-Cola، Yes, eighteen ninety something + +250 +00:21:38,190 --> 00:21:45,550 +Okay, another example، This، Yes, maybe Nestle، Steel + +251 +00:21:45,550 --> 00:21:50,270 +Industries، We have hundreds of examples on + +252 +00:21:50,270 --> 00:21:56,430 +companies with more than one hundred years، So, the + +253 +00:21:56,430 --> 00:22:03,890 +thing is as she said، الشركة الوحيدة لديها عيوب غير + +254 +00:22:03,890 --> 00:22:06,610 +محددة، ماذا يعني عبارة عن، عبارة عن، عبارة غير محددة + +255 +00:22:06,610 --> 00:22:11,350 +عبارة عن + +256 +00:22:11,350 --> 00:22:16,390 +عبارة + +257 +00:22:16,390 --> 00:22:22,670 +غير محددة، الـ personal accounts، حسناً دعونا نقرر ما + +258 +00:22:22,670 --> 00:22:27,210 +قلناه كما قلناه هنا، الـ business firms، الشركات + +259 +00:22:27,210 --> 00:22:28,770 +العامة العامة العامة العامة العامة العامة العامة + +260 +00:22:28,770 --> 00:22:29,790 +العامة العامة العامة العامة العامة العامة العامة + +261 +00:22:29,790 --> 00:22:31,650 +العامة العامة العامة عامة عامة عامة عامة عامة عامة + +262 +00:22:31,650 --> 00:22:33,630 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +263 +00:22:33,630 --> 00:22:33,670 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +264 +00:22:33,670 --> 00:22:37,210 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +265 +00:22:37,210 --> 00:22:46,550 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عام + +266 +00:22:46,590 --> 00:22:53,770 +للـ LLC لا يوجد تجارب مرتبطة مرتبطة، لأن خاطرات + +267 +00:22:53,770 --> 00:23:00,650 +الشركات مرتبطة + +268 +00:23:00,650 --> 00:23:04,430 +مرتبطة مرتبطة مرتبطة مرتبطة مرتبطة مرتبطة مرتبطة + +269 +00:23:04,430 --> 00:23:11,200 +مرتبطة مرتبطة مرتبطة مرتبطة مرتبطة، لذلك يأخذ + +270 +00:23:11,200 --> 00:23:15,860 +الحكومة ضريبة مرتين، واحدة من الأرباح، وواحدة من + +271 +00:23:15,860 --> 00:23:19,860 +المدفوعات، فهذه ضريبة مرتين، ولكن في هذا البرنامج + +272 +00:23:19,860 --> 00:23:24,440 +الوحيد، يأخذون ضريبة من تكلفة الحصول، فقط مرة + +273 +00:23:24,440 --> 00:23:29,820 +واحدة، فهذه الفرصة هنا هي الشركات، والفرصة في + +274 +00:23:29,820 --> 00:23:36,580 +البرنامج الوحيد، وفي الاتصالات فقط نركز على + +275 +00:23:36,580 --> 00:23:41,140 +الاتصالات، هنا في الاتصالات يفعلون بعض التغييرات + +276 +00:23:41,140 --> 00:23:45,200 +الصغيرة في الاتصالات، نحن لدينا اتصالات عامة ونحن + +277 +00:23:45,200 --> 00:23:49,200 +لدينا اتصالات محددة، ما هي الفرق بين اتصالات عامة + +278 +00:23:49,200 --> 00:23:57,680 +ومحددة؟ اتصالات عامة هي مصادر الشركة ومسؤولة في + +279 +00:23:57,680 --> 00:24:04,440 +إدارة الشركة، ولكن اتصالات محددة، انتبه، المشاركون + +280 +00:24:04,440 --> 00:24:09,060 +المحدودين هم فقط المشاركون أو المهندسين في الشبكة، + +281 +00:24:09,060 --> 00:24:14,160 +هم ليسوا مسؤولين في إدارة الشبكة ما هي مصطلحات + +282 +00:24:14,160 --> 00:24:19,660 +هذا؟ مصطلحات هذا هو أن المشاركين المحدودين ليسوا + +283 +00:24:19,660 --> 00:24:25,200 +مشاركين ليسوا + +284 +00:24:25,200 --> 00:24:29,580 +مشاركين ليسوا مشاركين ليسوا + +285 +00:24:29,580 --> 00:24:39,150 +مشاركين لما يعنيه قيادات محددة؟ يعني قيادات + +286 +00:24:40,880 --> 00:24:45,880 +المشاركات المحددة مستخدمة فقط للمال أو للمقدمات + +287 +00:24:45,880 --> 00:24:49,140 +التي تستخدمها في الشركة ولكن للمشاركات المحددة + +288 +00:24:49,140 --> 00:24:53,360 +المستخدمة، هذا يعني أنها لديها مشاركات مستخدمة غير + +289 +00:24:53,360 --> 00:24:58,760 +المقدمات التي تستخدمها في الشركة على سبيل المثال، + +290 +00:24:58,760 --> 00:25:02,540 +إذا كانت الشركة تتعامل مع مشاكل ومحاولات الشركة، + +291 +00:25:02,540 --> 00:25:05,760 +فالمشاركات، إذا كانوا مشاركات عامة، يمكنهم أن + +292 +00:25:05,760 --> 00:25:10,360 +يدفعوا أكثر مما يقوموا باستخدامه في الشركة و + +293 +00:25:10,360 --> 00:25:16,500 +هذا يسبب في مصادر اكتشاف شخصية هذا لا يحدث في + +294 +00:25:16,500 --> 00:25:19,080 +الشركات ولا يحدث في LLT + +295 +00:25:26,170 --> 00:25:31,050 +إذا كنت تحلم هذه الليلة لافتخار الصدر، فبإمكانك أن + +296 +00:25:31,050 --> 00:25:34,130 +تفعلها. لا عليك أن تتحدث مع آخرين لأنها قرار بسيط + +297 +00:25:34,130 --> 00:25:39,270 +جداً. ضريبة على الضريبة الشخصية كما قلت. لكن المفاجأة + +298 +00:25:39,270 --> 00:25:43,070 +هي مستوى الشخصي لتجارب الشركة ومن الممكن أن تتجه + +299 +00:25:43,070 --> 00:25:49,360 +لشركتك الشخصية سيزز على موت المستخدمين، يعني إذا + +300 +00:25:49,360 --> 00:25:54,080 +مات المستخدمين، فالعمل سيغلق مرتبطات مشابه + +301 +00:25:54,080 --> 00:25:58,880 +للمستخدمية الوحيدة، ولكن تتجاوز عدد المستخدمين + +302 +00:25:58,880 --> 00:26:04,280 +وليس هناك اختلاف بين المشاركات مشابه للمشاركة + +303 +00:26:04,280 --> 00:26:10,660 +السابقة ومباشرة وسهولة تبدأ الدفع للشخصيات مثلًا + +304 +00:26:10,660 --> 00:26:13,600 +مرة واحدة مرة واحدة مرة واحدة مرة واحدة مرة واحدة + +305 +00:26:13,600 --> 00:26:13,840 +مرة واحدة مرة واحدة مرة واحدة مرة واحدة مرة واحدة + +306 +00:26:13,840 --> 00:26:14,520 +مرة واحدة مرة واحدة مرة واحدة مرة واحدة مرة واحدة + +307 +00:26:14,520 --> 00:26:17,240 +مرة واحدة مرة واحدة مرة واحدة مرة واحدة مرة واحدة + +308 +00:26:17,240 --> 00:26:18,740 +مرة واحدة مرة واحدة مرة واحدة مرة واحدة مرة واحدة + +309 +00:26:18,740 --> 00:26:20,560 +مرة واحدة مرة واحدة مرة واحدة مرة واحدة مرة واحدة + +310 +00:26:20,560 --> 00:26:23,940 +مرة واحدة مرة واحدة مرة واحدة مرة واحدة مرة واحدة + +311 +00:26:23,940 --> 00:26:37,060 +مرة واحدة مرة واحدة + +312 +00:26:38,060 --> 00:26:41,160 +الشركات لا تريد أن تأخذ المخاطر مجتمع مجتمع مجتمع + +313 +00:26:41,160 --> 00:26:47,760 +مجتمع مجتمع مجتمع مجتمع مجتمع + +314 +00:26:47,760 --> 00:26:56,000 +مجتمع مجتمع مجتمع الشركات هي صورة كبيرة من الشركات + +315 +00:26:56,000 --> 00:27:00,880 +و إنتاجها أنها غير موجودة وغير موجودة وموجودة فقط + +316 +00:27:00,880 --> 00:27:04,720 +في التفكير في القواعد يجب أن تذهب من خلال القوانين + +317 +00:27:04,720 --> 00:27:09,360 +وفي بعض الأحيان يستغرقها أكثر من عامين لإبداء هذا + +318 +00:27:09,360 --> 00:27:13,740 +العمل ولكن في مقارنة مع المصادر السابقة يمكنك أن + +319 +00:27:13,740 --> 00:27:20,130 +تحلم الليلة وفي الصباح يمكنك أن تفتح عملك فهذا هو + +320 +00:27:20,130 --> 00:27:26,710 +...الشركات تستطيع تسوية وتكون تسوية بشريتها و + +321 +00:27:26,710 --> 00:27:30,790 +تسوية بشريتها وتسوية بشريتها وتسوية بشريتها و + +322 +00:27:30,790 --> 00:27:31,270 +تسوية بشريتها وتسوية بشريتها وتسوية بشريتها و + +323 +00:27:31,270 --> 00:27:31,370 +تسوية بشريتها وتسوية بشريتها وتسوية بشريتها و + +324 +00:27:31,370 --> 00:27:32,550 +تسوية بشريتها وتسوية بشريتها وتسوية بشريتها و + +325 +00:27:32,550 --> 00:27:33,050 +تسوية بشريتها وتسوية بشريتها وتسوية بشريتها و + +326 +00:27:33,050 --> 00:27:36,810 +تسوية بشريتها وتسوية بشريتها وتسوية بشريتها و + +327 +00:27:36,810 --> 00:27:43,150 +تسوية بشريتها و تسوية + +328 +00:27:43,150 --> 00:27:49,190 +بشريتها + +329 +00:27:51,260 --> 00:27:54,260 +الشركة مستعمرة بشكل حقيقي بشركاتها الحالية + +330 +00:27:54,260 --> 00:28:02,120 +فالشركات هنا هي شركات + +331 +00:28:02,120 --> 00:28:07,300 +أو شركات شركات + +332 +00:28:07,300 --> 00:28:14,920 +ثم الشركات تختار مجلد المديرين ثم مجلد المديرين + +333 +00:28:14,920 --> 00:28:20,690 +يختار مديرين أو رئيسين المديرين يعملون على محافظة + +334 +00:28:20,690 --> 00:28:24,470 +مؤسسات الـ Stockholders مؤسسات الـ Board of + +335 +00:28:24,470 --> 00:28:28,110 +Directors تم اختيارها من مؤسسات الشركات الشركات + +336 +00:28:28,110 --> 00:28:29,150 +الشركات الشركات الشركات الشركات الشركات الشركات + +337 +00:28:29,150 --> 00:28:29,290 +الشركات الشركات الشركات الشركات الشركات الشركات + +338 +00:28:29,290 --> 00:28:29,670 +الشركات الشركات الشركات الشركات الشركات الشركات + +339 +00:28:29,670 --> 00:28:30,770 +شركات الشركات شركات شركات شركات شركات شركات شركات + +340 +00:28:30,770 --> 00:28:30,870 +شركات + +341 +00:28:36,120 --> 00:28:39,460 +Liability of owners limited to invested funds. If + +342 +00:28:39,460 --> 00:28:43,800 +for instance, the investors here invest one + +343 +00:28:43,800 --> 00:28:47,460 +million dollars, so the investors are only liable + +344 +00:28:47,460 --> 00:28:50,600 +for one million dollars. But in the case of the + +345 +00:28:50,600 --> 00:28:54,580 +sole and the partnerships is unlimited + +346 +00:28:57,690 --> 00:29:01,550 +Life of corporation as some students said is not + +347 +00:29:01,550 --> 00:29:05,290 +tied to the owner, so the lifespan is greater than + +348 +00:29:05,290 --> 00:29:09,050 +the others, easier to transfer the ownership, for + +349 +00:29:09,050 --> 00:29:11,110 +instance if I'm the owner of this business, I can + +350 +00:29:11,110 --> 00:29:13,110 +sell the shares to the other people, so the + +351 +00:29:13,110 --> 00:29:16,310 +ownership is transferred from people to another, + +352 +00:29:16,790 --> 00:29:20,010 +it's like you can go to the financial market and + +353 +00:29:20,010 --> 00:29:24,900 +do it أسهل أن تحفز المال إذا طلبت من البنك أن يعطيك + +354 +00:29:24,900 --> 00:29:29,600 +مالاً أو دفعات، يمكنك بسهولة الحصول على دفعات مثل + +355 +00:29:29,600 --> 00:29:33,200 +هذه، المفادة هي أن القوانين الأكبر يمكنها أن تأخذ + +356 +00:29:33,200 --> 00:29:39,840 +2 أو 3 عاماً لإبداء هذه الشركة و المشكلة التجارية + +357 +00:29:39,840 --> 00:29:44,180 +التقسيمية، كيف تقضي هذه المفادلات بالنسبة + +358 +00:29:44,180 --> 00:29:52,480 +للمستخدمات والمؤسسات، فالـ hybrid هي الحلول، LLC + +359 +00:29:52,480 --> 00:29:57,020 +هي الحلول، هي إزالة المفادلات من كلا + +360 +00:30:00,580 --> 00:30:05,160 +هذه الشركات المشتركة تقدم مقاومة بين شركات وشركات + +361 +00:30:05,160 --> 00:30:07,060 +شركات وشركات وشركات وشركات وشركات وشركات وشركات + +362 +00:30:07,060 --> 00:30:07,120 +وشركات وشركات وشركات وشركات وشركات وشركات وشركات + +363 +00:30:07,120 --> 00:30:09,660 +وشركات وشركات وشركات وشركات وشركات وشركات وشركات + +364 +00:30:09,660 --> 00:30:10,900 +وشركات وشركات وشركات وشركات وشركات وشركات وشركات + +365 +00:30:10,900 --> 00:30:18,340 +وشركات وشركات وشركات وشركات وشركات وشركات وشركات + +366 +00:30:18,340 --> 00:30:21,280 +وشرك + +367 +00:30:21,500 --> 00:30:25,840 +الأول هو أنك لا تحتاج أن تدفع تقسيم مرتفعة مرتفعة + +368 +00:30:25,840 --> 00:30:28,880 +مرتفعة مرتفعة مرتفعة مرتفعة مرتفعة مرتفعة مرتفعة + +369 +00:30:28,880 --> 00:30:33,280 +مرتفعة مرتفعة مرتفعة + +370 +00:30:35,250 --> 00:30:39,470 +المفادات المشاركة هي أنها لديها قيادات غير محدودة + +371 +00:30:39,470 --> 00:30:44,370 +ولكن في هذه المجموعة لديها قيادات محدودة. الآن + +372 +00:30:44,370 --> 00:30:48,570 +الضرائب المتسللة في واحد من المفاداة من الشركات + +373 +00:30:48,570 --> 00:30:55,390 +ولكن هنا ليس مشكلة هذا السبب أن بعض الشركات تفضل + +374 +00:30:55,390 --> 00:31:02,590 +أن تذهب إلى الـ LLC لإبداء LLC ومثال أساسي أو مثال + +375 +00:31:02,590 --> 00:31:08,930 +حقيقي للـ LLC هو KPMG كمبيوتر KPMG هو مثال حقيقي لل + +376 +00:31:08,930 --> 00:31:17,290 +LLC مثال حقيقي لشركات مثل Google, Yahoo, British + +377 +00:31:17,290 --> 00:31:22,190 +Petroleum جنرال موتورز، جنرال إلكتريكس، بالتل، + +378 +00:31:22,190 --> 00:31:26,870 +Vodafone، Bank of Palestine، AIB لذلك لدينا الكثير + +379 +00:31:26,870 --> 00:31:35,270 +من الأمثلة عن الشركات حسنًا كما يبدو أن الشركات + +380 +00:31:35,270 --> 00:31:39,830 +السعودية تقدم هذه تبدو مثل الـ LLC مرة أخرى تقدم + +381 +00:31:39,830 --> 00:31:43,110 +لعبات محددة وأنا أشرح هذا بينما يسمح لشركات + +382 +00:31:43,110 --> 00:31:46,250 +الشركات العامة أن تكون تجارباً كإذا كانوا شركات + +383 +00:31:46,250 --> 00:31:50,680 +متشاركة فقط تجارة واحدة تجارة واحدة تجارة واحدة + +384 +00:31:50,680 --> 00:31:52,140 +تجارة واحدة تجارة واحدة تجارة واحدة تجارة واحدة + +385 +00:31:52,140 --> 00:31:53,240 +تجارة واحدة تجارة واحدة تجارة واحدة تجارة واحدة + +386 +00:31:53,240 --> 00:31:55,560 +تجارة واحدة تجارة واحدة تجارة واحدة تجارة واحدة + +387 +00:31:55,560 --> 00:32:04,800 +تجارة واحدة تجارة واحدة تجارة واحدة تجارة واحدة + +388 +00:32:04,800 --> 00:32:07,760 +تجارة واحدة تجارة واحدة تجارة واحدة تجارة واحدة + +389 +00:32:07,760 --> 00:32:14,400 +تجارة واحدة + +390 +00:32:16,000 --> 00:32:20,720 +الشركات المستخدمة مستخدمة ومستخدمة ومستخدمة + +391 +00:32:20,720 --> 00:32:22,620 +ومستخدمة ومستخدمة ومستخدمة ومستخدمة ومستخدمة + +392 +00:32:22,620 --> 00:32:25,780 +ومستخدمة ومستخدمة ومستخدمة ومستخدمة ومستخدمة + +393 +00:32:25,780 --> 00:32:27,080 +ومستخدمة ومستخدمة ومستخدمة ومستخدمة ومستخدمة + +394 +00:32:27,080 --> 00:32:27,220 +ومستخدمة ومستخدمة ومستخدمة ومستخدمة ومستخدمة + +395 +00:32:27,220 --> 00:32:27,240 +ومستخدمة ومستخدمة ومستخدمة ومستخدمة ومستخدمة + +396 +00:32:27,240 --> 00:32:33,800 +ومستخدمة ومستخدمة ومستخدمة ومستخدمة ومستخدمة + +397 +00:32:33,800 --> 00:32:40,640 +ومستخدمة ومستخدمة + +398 +00:32:40,640 --> 00:32:45,780 +ومستخدمة + +399 +00:32:46,120 --> 00:32:52,240 +هل يتغير الحصة؟ نعم هنا لكنه يجب أن يتحرر وينتهي + +400 +00:32:52,240 --> 00:32:57,720 +ويتخلص من هنا نفس الشيء هنا لكن هنا لا لأن إذا .. + +401 +00:32:57,720 --> 00:33:03,120 +دعنا نقول إن الحصة ماتت يعني أن الشركات ستتحرك إلى + +402 +00:33:03,120 --> 00:33:08,220 +الناس الآخرين إلى زوجته إلى أبنائه إلى أبنائها إلى + +403 +00:33:08,220 --> 00:33:08,360 +أبنائها إلى أبناء أبناء أبناء أبناء أبناء أبناء + +404 +00:33:08,360 --> 00:33:08,660 +أبناء أبناء أبناء أبناء أبناء أبناء أبناء أبناء + +405 +00:33:08,660 --> 00:33:09,780 +أبناء أبناء أبناء أبناء أبناء أبناء أبناء أبناء + +406 +00:33:09,780 --> 00:33:12,080 +أبناء أبناء أبناء أبناء أبناء أبناء أبناء + +407 +00:33:13,780 --> 00:33:19,640 +this is the comparison of ... of different types of + +408 +00:33:19,640 --> 00:33:24,900 +the business any question related to this? any + +409 +00:33:24,900 --> 00:33:35,030 +question? okay no question? example هوكي بي ام جي + +410 +00:33:35,030 --> 00:33:41,730 +كي بي ام جي كي بي ام جي كي + +411 +00:33:41,730 --> 00:33:46,690 +بي ام جي كي بي ام جي كي بي ام جي كي بي + +412 +00:33:46,690 --> 00:33:48,650 +ام جي كي بي ام جي كي بي ام جي كي بي ام جي كي بي + +413 +00:33:48,650 --> 00:33:51,870 +جي كي بي ام جي كي بي ام جي كي بي ام جي كي بي ام جي + +414 +00:33:51,870 --> 00:33:52,330 +كي بي ام جي كي بي ام جي كي بي ام جي كي بي ام جي كي + +415 +00:33:52,330 --> 00:33:54,570 +بي ام جي كي بي ام جي كي بي ام جي كي بي ام جي كي بي + +416 +00:33:54,570 --> 00:34:06,040 +ام جي كي بي ام جي كي بي ام جي كي بي ام جي مثال + +417 +00:34:06,040 --> 00:34:10,380 +للشركات لدينا الكثير من المثال للشركات ولكن أكون + +418 +00:34:10,380 --> 00:34:16,180 +حذرًا هذه أشكال مؤسسة بسيطة هذا ليس كل شركات مؤسسة + +419 +00:34:16,180 --> 00:34:25,740 +مثلاً لدينا الشركات لدينا شركات مصممة لأنك قد سألت + +420 +00:34:25,740 --> 00:34:36,240 +عنها لذا قصة حياتنا هي مثل هذه بدأت بصول الناس تعرف + +421 +00:34:36,240 --> 00:34:40,200 +بعضها البعض و تصبحوا شركات اشتراك مع بعضها البعض + +422 +00:34:40,200 --> 00:34:44,420 +الناس تريدون أن تفتحوا معرفتهم مع أشخاص مختلفة مثل + +423 +00:34:44,420 --> 00:34:51,160 +الشركات الشركات تريدون أن تعرفوا ما هي البلد + +424 +00:34:51,160 --> 00:34:55,580 +التالفة و تعملوا شركات مع بعضها البعض إذا كانوا + +425 +00:34:55,580 --> 00:34:57,240 +يريدون أن يعملوا شركات مختلفة مع بعضها البعض إذا + +426 +00:34:57,240 --> 00:34:58,680 +كانوا يريدون أن يعملوا شركات مختلفة مع بعضها البعض + +427 +00:34:58,680 --> 00:34:59,140 +إذا كانوا يريدون أن يعملوا شركات مختلفة مع بعضها + +428 +00:34:59,140 --> 00:35:00,640 +البعض إذا كانوا يريدون أن يعملوا شركات مختلفة مع + +429 +00:35:05,210 --> 00:35:10,890 +وهو مجتمع .. بعض المجتمعات من الشركة فهذه هي قصة + +430 +00:35:10,890 --> 00:35:15,970 +أخرى شركات .. نحن نتكلم عنها .. فهي حسنا .. نتكلم + +431 +00:35:15,970 --> 00:35:20,450 +عن هذا .. هذه قصة كبيرة عن شركات ومجتمعين مجتمعين + +432 +00:35:20,450 --> 00:35:23,930 +مجتمعين مجتمعين مجتمعين مجتمعين مجتمعين مجتمعين + +433 +00:35:23,930 --> 00:35:23,990 +مجتمعين مجتمعين مجتمعين مجتمعين مجتمعين مجتمعين + +434 +00:35:23,990 --> 00:35:24,050 +مجتمعين مجتمعين مجتمعين مجتمعين مجتمعين مجتمعين + +435 +00:35:24,050 --> 00:35:24,070 +مجتمعين مجتمعين مجتمعين مجتمعين مجتمعين مجتمعين + +436 +00:35:24,070 --> 00:35:24,330 +مجتمعين مجتمعين مجتمعين مجتمعين مجتمعين + +437 +00:35:35,750 --> 00:35:38,630 +كيف تشبه الإنسان الإنسان الإنسان الإنسان الإنسان + +438 +00:35:38,630 --> 00:35:39,310 +الإنسان الإنسان الإنسان الإنسان الإنسان الإنسان + +439 +00:35:39,310 --> 00:35:40,530 +الإنسان الإنسان الإنسان الإنسان الإنسان الإنسان + +440 +00:35:40,530 --> 00:35:44,870 +الإنسان الإنسان الإنسان الإنسان الإنسان الإنسان + +441 +00:35:44,870 --> 00:35:49,550 +الإنسان الإنسان الإنسان الإنسان الإنسان الإنسان + +442 +00:35:49,550 --> 00:35:50,530 +الإنسان الإنسان الإنسان الإنسان الإنسان الإنسان + +443 +00:35:50,530 --> 00:35:50,570 +الإنسان الإنسان الإنسان الإنسان الإنسان الإنسان + +444 +00:35:50,570 --> 00:36:01,950 +الإنسان الإنسان + +445 +00:36:03,390 --> 00:36:07,170 +if you say هي the board of director here and he is + +446 +00:36:07,170 --> 00:36:12,730 +the chief executive officer here and he is the + +447 +00:36:12,730 --> 00:36:18,750 +chief financial officer then + +448 +00:36:18,750 --> 00:36:21,970 +the chief of financial officer .. chief of + +449 +00:36:21,970 --> 00:36:29,710 +financial officer here and doing like this مصطلح + +450 +00:36:29,710 --> 00:36:34,330 +مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح + +451 +00:36:34,330 --> 00:36:39,070 +مصطلح مصطلح مصطلح مصطلح + +452 +00:36:39,070 --> 00:36:43,770 +مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح + +453 +00:36:43,770 --> 00:36:43,850 +مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح + +454 +00:36:43,850 --> 00:36:58,010 +مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصط + +455 +00:36:58,230 --> 00:37:03,730 +الصحيفة الاجتماعية وفي الواضح أنهم يقومون بالتخطيط + +456 +00:37:03,730 --> 00:37:12,670 +في الشبكة لديهم رؤية الشبكة لديهم مهمة الشبكة لذا + +457 +00:37:12,670 --> 00:37:17,930 +هم يعملون في مستوى استراتيجي هذا مهم و لفعل هذا + +458 +00:37:17,930 --> 00:37:23,570 +لديهم اثنين عمليات أساسية عمليات مرتبطة بالأسلحة + +459 +00:37:25,810 --> 00:37:30,710 +التحقيقات هنا مرتبطة بخيارات الاستخدام التحقيقات + +460 +00:37:30,710 --> 00:37:33,110 +هنا مرتبطة باختيار الاستخدام الاستخدام الاستخدام + +461 +00:37:33,110 --> 00:37:33,670 +الاستخدام الاستخدام الاستخدام الاستخدام الاستخدام + +462 +00:37:33,670 --> 00:37:37,770 +الاستخدام الاستخدام الاستخدام الاستخدام الاستخدام + +463 +00:37:37,770 --> 00:37:39,850 +الاستخدام الاستخدام الاستخدام الاستخدم الاستخدم + +464 +00:37:39,850 --> 00:37:40,010 +الاستخدم الاستخدم الاستخدم الاستخدم الاستخدم + +465 +00:37:40,010 --> 00:37:40,130 +الاستخدم الاستخدم الاستخدام الاستخدام الاستخدام + +466 +00:37:40,130 --> 00:37:42,530 +الاستخدم الاستخدام الاستخدام الاستخدام الاستخدام + +467 +00:37:42,530 --> 00:37:49,470 +الاستخدام الاستخدام الاستخدام + +468 +00:37:49,470 --> 00:37:53,910 +الاستخدام + +469 +00:37:53,910 --> 00:37:59,550 +الاستماع النهاية كما تشاهد، كما أشرح في تاريخ MESA + +470 +00:37:59,550 --> 00:38:07,120 +إذا كنت تنظر إلى هذا التاريخ مغلق جدا الصحيفة + +471 +00:38:07,120 --> 00:38:11,720 +الأمريكية المالية هنا هي المسؤولة عن التخطيط + +472 +00:38:11,720 --> 00:38:15,900 +الأمريكي التخطيط كما قلت هي تخطيط مثل التخطيط + +473 +00:38:15,900 --> 00:38:19,220 +التخطيط الأمريكي التخطيط التخطيط التخطيط التخطيط + +474 +00:38:19,220 --> 00:38:20,140 +التخطيط التخطيط التخطيط التخطيط التخطيط التخطيط + +475 +00:38:20,140 --> 00:38:20,480 +التخطيط التخطيط التخطيط التخطيط التخطيط التخطيط + +476 +00:38:20,480 --> 00:38:22,560 +التخطيط التخطيط التخطيط التخطيط التخطيط التخطيط + +477 +00:38:22,560 --> 00:38:24,300 +التخطيط التخطيط التخطيط التخطيط التخطيط التخطيط + +478 +00:38:24,300 --> 00:38:29,460 +التخطيط التخطيط التخطيط التخطيط + +479 +00:38:32,040 --> 00:38:36,580 +يحتاجون أن يكونوا حذرين في إدارة الأشياء التجارية + +480 +00:38:36,580 --> 00:38:42,120 +والتحكم فيها التجارة هي مرتبطة بالاستثمارات المهمة + +481 +00:38:42,120 --> 00:38:46,740 +هي إدارة المال المدفع المدفع المدفع المدفع المدفع + +482 +00:38:46,740 --> 00:38:50,340 +المدفع المدفع المدفع المدفع المدفع المدفع المدفع + +483 +00:38:50,340 --> 00:38:52,680 +المدفع المدفع المدفع المدفع المدفع المدفع المدفع + +484 +00:38:52,680 --> 00:38:53,780 +المدفع المدفع المدفع المدفع المدفع المدفع المدفع + +485 +00:38:53,780 --> 00:38:54,420 +المدفع المدفع المدفع المدفع المدفع المدفع المدفع + +486 +00:38:54,420 --> 00:38:54,640 +المدفع المدفع المدفع المدفع المدفع المدفع المدفع + +487 +00:38:54,640 --> 00:38:54,820 +المدفع المدفع المدفع المدفع المدفع المدفع المدفع + +488 +00:38:54,820 --> 00:38:55,300 +المدفع المدفع المدفع المدفع المدفع المدفع المدفع + +489 +00:38:55,300 --> 00:38:58,860 +المدفع المدفع + +490 +00:39:13,810 --> 00:39:22,130 +سنوقف هنا و فقط لأذكركم أن ما تحدثنا عنه اليوم هو + +491 +00:39:22,130 --> 00:39:27,730 +مهمة الانبعاث والطرق التي يتجاوزها المؤسسة + +492 +00:39:27,730 --> 00:39:33,010 +والأخيرة هي كيف تتجاوز الانبعاث في مصمم المؤسسة + +493 +00:39:35,880 --> 00:39:39,160 +عندما تعود، عندما تذهب إلى المنزل، اقرأ فقط حول هذه + +494 +00:39:39,160 --> 00:39:42,400 +القصة وفي المقابلة التالية إن شاء الله سأنتهي هذه + +495 +00:39:42,400 --> 00:39:48,600 +القصة و أذهب إلى القصة الثانية مرة أخرى، نشكر + +496 +00:39:48,600 --> 00:39:55,720 +الناس خلف السجن أو خلف المسرح أنهم يلاحظونا و + +497 +00:39:55,720 --> 00:39:59,120 +يحاولون أن يساعدونا لإصلاح الموضوع بشكل صحيح diff --git a/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/fQFzcZ704vA_postprocess.srt b/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/fQFzcZ704vA_postprocess.srt new file mode 100644 index 0000000000000000000000000000000000000000..51e4e123e5157f55254012315256395eef8d6890 --- /dev/null +++ b/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/fQFzcZ704vA_postprocess.srt @@ -0,0 +1,2160 @@ +1 +00:00:20,270 --> 00:00:25,350 +بسم الله الرحمن الرحيم this + +2 +00:00:25,350 --> 00:00:30,190 +course is about financial management okay today + +3 +00:00:30,190 --> 00:00:34,430 +inshallah I will give you a brief on this course + +4 +00:00:34,430 --> 00:00:38,410 +focusing on the main objective of financial + +5 +00:00:38,410 --> 00:00:43,990 +management or the main objective of this coursethe + +6 +00:00:43,990 --> 00:00:48,130 +.. talk about the textbook and how we are marking + +7 +00:00:48,130 --> 00:00:52,050 +the assignment and exams and finally some + +8 +00:00:52,050 --> 00:00:54,770 +regulations related to this course first of all + +9 +00:00:54,770 --> 00:01:00,930 +you .. in order to see the .. the course plan you + +10 +00:01:00,930 --> 00:01:06,830 +should go to the .. to my website okay in the IOG + +11 +00:01:06,830 --> 00:01:14,020 +go to the مساخاتثم هذا هو خطة دراساتنا الاناليزية + +12 +00:01:14,020 --> 00:01:17,240 +الاناليزية الاناليزية الاناليزية الاناليزية + +13 +00:01:17,240 --> 00:01:19,900 +الاناليزية الاناليزية الاناليزية الاناليزية + +14 +00:01:19,900 --> 00:01:20,920 +الاناليزية الاناليزية الاناليزية الاناليزية + +15 +00:01:20,920 --> 00:01:24,260 +الاناليزية الاناليزية الاناليزية الاناليزية + +16 +00:01:24,260 --> 00:01:25,440 +الاناليزية الاناليزية الاناليزية الاناليزية + +17 +00:01:25,440 --> 00:01:26,940 +الاناليزية الاناليزية الاناليزية الاناليزية + +18 +00:01:26,940 --> 00:01:28,700 +الاناليزية الاناليزية الاناليزية الاناليزية + +19 +00:01:28,700 --> 00:01:28,940 +الاناليزية الاناليزية الاناليزية الاناليزية + +20 +00:01:28,940 --> 00:01:38,520 +الاناليزية الاناليزية الان + +21 +00:01:40,670 --> 00:01:46,650 +إذا كنت تذهب إلى خطة البرامج الخاصة بنا هنا خطة + +22 +00:01:46,650 --> 00:01:52,050 +البرامج الخاصة بنا فاكتشف + +23 +00:01:52,050 --> 00:01:55,990 +هنا خطة البرامج الخاصة بنا فاكتشف هنا خطة البرامج + +24 +00:01:55,990 --> 00:02:01,130 +الخاصة بنا خطة البرامج الخاصة بنا + +25 +00:02:04,570 --> 00:02:10,410 +والقادة في المدرسة هي أنا وهذه إيميلي وائل أبدايا + +26 +00:02:10,410 --> 00:02:14,370 +وهذه إيميلي إذا كان لديك أي مشكلة فإيميلي لي + +27 +00:02:18,960 --> 00:02:22,760 +Aims are prerequisites. It's important to have + +28 +00:02:22,760 --> 00:02:25,620 +some principles in microeconomics and accounting + +29 +00:02:25,620 --> 00:02:27,920 +as well As you see it's highly recommended that + +30 +00:02:27,920 --> 00:02:33,380 +students have a knowledge about the principles of + +31 +00:02:33,380 --> 00:02:38,420 +microeconomics and microeconomics in addition to + +32 +00:02:38,420 --> 00:02:45,900 +the statistics and accounting Aims + +33 +00:02:45,900 --> 00:02:51,130 +and description of this bookكما ترى، هذه الدراسة + +34 +00:02:51,130 --> 00:02:56,190 +تهتم بإعطاء وإيقاف فهم الأدوات الأساسية والأساسيات + +35 +00:02:56,190 --> 00:03:02,830 +الأساسية. لذلك، مهمة عمل هذا العمل هو أن يكون هناك + +36 +00:03:02,830 --> 00:03:06,590 +خلفية للخدمة. لسنا نتكلم عن المواضيع الخارقة + +37 +00:03:06,590 --> 00:03:08,130 +الخارقة الخارقة الخارقة الخارقة الخارقة الخارقة + +38 +00:03:08,130 --> 00:03:09,290 +الخارقة الخارقة الخارقة الخارقة الخارقة الخارقة + +39 +00:03:09,290 --> 00:03:11,070 +الخارقة الخارقة الخارقة الخارقة الخارقة الخارقة + +40 +00:03:11,070 --> 00:03:14,070 +الخارقة الخارقة الخارقة الخارقة الخارقة الخارقة + +41 +00:03:14,070 --> 00:03:14,870 +الخارقة الخارقة الخارقة الخارقة الخارقة الخارقة + +42 +00:03:14,870 --> 00:03:16,970 +الخارقة الخارقة الخارقة الخارلترسم صورة كبيرة من + +43 +00:03:16,970 --> 00:03:20,830 +التعامل، عليك أن تكون لديك مؤسسة في التعامل، لذلك + +44 +00:03:20,830 --> 00:03:28,610 +سوف نركز على مصادر التعامل التي + +45 +00:03:28,610 --> 00:03:32,350 +يتضمن مصادر التعامل، مصادر التعامل ومصادر تدفع + +46 +00:03:32,350 --> 00:03:40,140 +المالسنتحدث عن قيمة الأسعار، قيمة المعاملات وRisk + +47 +00:03:40,140 --> 00:03:45,800 +and Return Investment Management ومنطقات هذه + +48 +00:03:45,800 --> 00:03:49,980 +الموضوعات لإنهاء + +49 +00:03:49,980 --> 00:03:54,000 +هذه الهدفات، يجب أن تقضي المعاملات، بإضافة إلى أن + +50 +00:03:54,000 --> 00:03:57,700 +تقوم ببعض المهاجمات. منذ البداية، من المهم أن + +51 +00:03:57,700 --> 00:04:05,670 +تختار شركة معينة من المعاملات الماليةتكون لديك S + +52 +00:04:05,670 --> 00:04:10,210 +&P500 او FTSE 100 او من مجتمع المجتمع المجتمع + +53 +00:04:10,210 --> 00:04:14,270 +المجتمع المجتمع المجتمع المجتمع المجتمع المجتمع + +54 +00:04:14,270 --> 00:04:14,470 +المجتمع المجتمع المجتمع المجتمع المجتمع المجتمع + +55 +00:04:14,470 --> 00:04:16,150 +المجتمع المجتمع المجتمع المجتمع المجتمع المجتمع + +56 +00:04:16,150 --> 00:04:18,290 +المجتمع المجتمع المجتمع المجتمع المجتمع المجتمع + +57 +00:04:18,290 --> 00:04:19,350 +المجتمع المجتمع المجتمع المجتمع المجتمع المجتمع + +58 +00:04:19,350 --> 00:04:19,830 +المجتمع المجتمع المجتمع المجتمع المجتمع المجتمع + +59 +00:04:19,830 --> 00:04:20,130 +المجتمع المجتمع المجتمع المجتمع المجتمع المجتمع + +60 +00:04:20,130 --> 00:04:30,070 +المجتم + +61 +00:04:31,400 --> 00:04:34,740 +أيضًا يمكنك إختيار شركة مخصصة من ماركتنا الموجودة، + +62 +00:04:34,740 --> 00:04:37,620 +على سبيل المثال، يمكنك إختيار شركة من شركة + +63 +00:04:37,620 --> 00:04:44,800 +Palestine Stock Exchange، دعنا نقول عن بالتل أو + +64 +00:04:44,800 --> 00:04:48,020 +يمكنك أن تتحدث عن بانكو بالستان أو عرب اسلاميك + +65 +00:04:48,020 --> 00:04:53,220 +بانك، بديكو، بيك، أي شركة التي تستطيع الحصول عليها + +66 +00:04:53,220 --> 00:04:58,090 +أو الحصول على مصادرهاتحاول تفكير من البداية عن + +67 +00:04:58,090 --> 00:05:06,890 +شركة معينة لأنها مهمة للوصول لتلقاء عملياتك ثم + +68 +00:05:06,890 --> 00:05:13,750 +السنوات أو القصص مختلفة على سنوات مختلفة لذا لدينا + +69 +00:05:13,750 --> 00:05:17,890 +16 سنوات كما تعلمين في السنة الأولى سنتحدث عن + +70 +00:05:17,890 --> 00:05:22,570 +أساسات التدفقOkay, why we are studying finance? + +71 +00:05:22,830 --> 00:05:25,550 +What is the importance of finance? And what are + +72 +00:05:25,550 --> 00:05:29,310 +the main principles of finance? In the second + +73 +00:05:29,310 --> 00:05:31,290 +week, we will talk about firms and financial + +74 +00:05:31,290 --> 00:05:36,370 +markets because trading the securities, I mean the + +75 +00:05:36,370 --> 00:05:41,330 +investment tools, it should be traded in the + +76 +00:05:41,330 --> 00:05:47,470 +financial market. If you don't haveمعرفة كيف تعمل + +77 +00:05:47,470 --> 00:05:53,610 +السوق الاجتماعي يعني أنك لا تفهم كيف تتجه الانتجار + +78 +00:05:53,610 --> 00:05:58,950 +من الجزء السياسي إلى الجزء المفقود فهذا مهم في هذه + +79 +00:05:58,950 --> 00:06:02,390 +الفترة ثلاثة أسابيع تفهيم الانتجار الاجتماعي كما + +80 +00:06:02,390 --> 00:06:05,390 +قلت والتي تحتوي على بلنشيط الانتجار الاجتماعي + +81 +00:06:05,390 --> 00:06:09,650 +ومعرفة الانتجار الاجتماعي هنا لا أطلب منك أن تجهز + +82 +00:06:09,650 --> 00:06:16,410 +هذه المعرفة هذا ليس مهمتيهو كيف تفهم جزء من هذه + +83 +00:06:16,410 --> 00:06:22,810 +الاختصارات ومفروضية هذه الاختصارات لأن الفرق بين + +84 +00:06:22,810 --> 00:06:30,210 +المال ومنطقات أخرى أو مدرسات أخرى في الوظيفة دعونا + +85 +00:06:30,210 --> 00:06:36,290 +نعتبرها الاقتصاد المال ينفجر بين الاقتصاد والمعرفة + +86 +00:06:36,290 --> 00:06:43,030 +كما قلت المعرفة هي تسجيل التعاملاتالعالمية هي أن + +87 +00:06:43,030 --> 00:06:46,830 +ترى إفعالة وإفعالة لشركة معينة على سبيل المثال، + +88 +00:06:46,830 --> 00:06:50,930 +ولكن الواقعية هي أن ترى إذا كنت تشتري أو تسوي هذه + +89 +00:06:50,930 --> 00:06:54,250 +الشركة، لذلك الواقعية مرتبطة بشكل كبير مع + +90 +00:06:54,250 --> 00:06:56,610 +الاختيارات المالية أو المالية + +91 +00:06:58,920 --> 00:07:01,660 +في الأسبوع السادسة و السادسة سنتحدث عن قيمة وقت + +92 +00:07:01,660 --> 00:07:06,340 +المال لأن اليوم الواحد دولار لا يقل الواحد دولار + +93 +00:07:06,340 --> 00:07:09,720 +غير اليوم كيف نستطيع أن نفتح هذه النظرات على + +94 +00:07:09,720 --> 00:07:17,460 +مستخدماتنا، لذا إذا انتقلت 100 اليوم، ما هي الميزة + +95 +00:07:17,460 --> 00:07:25,740 +من 100 في المستقبل؟ كم تتوقع منه في المستقبل؟ وهذه + +96 +00:07:25,740 --> 00:07:31,320 +التحقيقات يجب أن تغطي رقم الانفلاحسوف نتكلم عن عمل + +97 +00:07:31,320 --> 00:07:36,080 +وقت المال في الأسبوع 8 و9 سنتكلم عن رسق و عادة وهو + +98 +00:07:36,080 --> 00:07:41,340 +عامل اختيار بين رسق و عادة أكتر رسق تحمله تسأل عن + +99 +00:07:41,340 --> 00:07:49,450 +أكتر عادة ومدار التجارب ستكون في الأسبوع 8في السنة + +100 +00:07:49,450 --> 00:07:54,210 +10 و11 سنتحدث عن نظرية السوق المالية نظرية السوق + +101 +00:07:54,210 --> 00:07:57,590 +المالية هي حاولة تتعامل مع مدارس مالية مختلفة + +102 +00:07:57,590 --> 00:08:04,560 +بالنسبة للأسعار بالنسبة للدفعاتوفي الأسبوع 12 و13 + +103 +00:08:04,560 --> 00:08:08,720 +سنتحدث عن قرارات اختيارات الاستثمار، كيف نتعامل مع + +104 +00:08:08,720 --> 00:08:13,560 +اختلافات الاستثمار باستخدام الكثير من الأدوات، بما + +105 +00:08:13,560 --> 00:08:18,000 +في ذلك قيمة الدفع الداخلية لـ IRR، قيمة مالية + +106 +00:08:18,000 --> 00:08:23,040 +الانترنت، MIR، XIRR، XMIR، لدينا الكثير من الأدوات + +107 +00:08:23,040 --> 00:08:28,670 +التي يمكننا استخدامها للتعامل مع مشروع الاستثمارفي + +108 +00:08:28,670 --> 00:08:33,350 +الساعة 14 سنتحدث عن قيمة المال وفي الساعة 15 + +109 +00:08:33,350 --> 00:08:36,710 +سنتحدث عن قيمة الأسعار وفي الساعة 16 ستحدث عن + +110 +00:08:36,710 --> 00:08:41,810 +محافظتك الأخيرة ماركنجنا + +111 +00:08:41,810 --> 00:08:49,870 +يتجه بهذه الطريقة ماركنجنا + +112 +00:08:49,870 --> 00:08:53,350 +في محافظتك الثانوية الثالثة + +113 +00:08:56,620 --> 00:09:03,660 +مارك و سنقرر كيف نتناقض على هذا الوقت الساعة + +114 +00:09:03,660 --> 00:09:07,720 +اكتشاف اكتشاف اكتشاف اكتشاف اكتشاف اكتشاف اكتشاف + +115 +00:09:07,720 --> 00:09:08,180 +اكتشاف اكتشاف اكتشاف اكتشاف اكتشاف اكتشاف اكتشاف + +116 +00:09:08,180 --> 00:09:08,740 +اكتشاف اكتشاف اكتشف اكتشف اكتشف اكتشف اكتشف اكتشف + +117 +00:09:08,740 --> 00:09:09,180 +اكتشف اكتشف اكتشف اكتشف اكتشف اكتشف اكتشف اكتشف + +118 +00:09:09,180 --> 00:09:09,260 +اكتشف اكتشف اكتشف اكتشف اكتشف اكتشف اكتشف اكتشف + +119 +00:09:09,260 --> 00:09:09,600 +اكتشف اكتشف + +120 +00:09:26,090 --> 00:09:29,110 +if you are not writing the assignment properly + +121 +00:09:29,110 --> 00:09:33,090 +according to your academic level now you are in + +122 +00:09:33,090 --> 00:09:35,390 +the fourth year or in the third year it means you + +123 +00:09:35,390 --> 00:09:39,310 +should think that you are in the third year you + +124 +00:09:39,310 --> 00:09:42,070 +are not in the secondary school you are in the + +125 +00:09:42,070 --> 00:09:46,390 +university so try to think how to write a proper + +126 +00:09:46,390 --> 00:09:50,140 +assignmenthow to think, the writing style, the + +127 +00:09:50,140 --> 00:09:52,760 +format of your writing, the referencing style and + +128 +00:09:52,760 --> 00:09:57,040 +other areas of writing and by the way I will do + +129 +00:09:57,040 --> 00:10:01,920 +like workshop like the previous or last year for + +130 +00:10:01,920 --> 00:10:05,940 +the students how to write the assignments it's + +131 +00:10:05,940 --> 00:10:09,560 +important because I try to put my efforts in this + +132 +00:10:09,560 --> 00:10:16,830 +because it's influence on your evaluationnot just + +133 +00:10:16,830 --> 00:10:20,630 +rushing the assignment like rushing just be + +134 +00:10:20,630 --> 00:10:24,090 +careful when you are writing the assignment as the + +135 +00:10:24,090 --> 00:10:26,770 +assignment reflects that you are in the third or + +136 +00:10:26,770 --> 00:10:31,560 +in the fourth year of your degreeand the final + +137 +00:10:31,560 --> 00:10:38,220 +exam fifty okay about your textbook it's fine to + +138 +00:10:38,220 --> 00:10:41,840 +talk about your textbook this book financial + +139 +00:10:41,840 --> 00:10:45,760 +management principles and applications for titman + +140 +00:10:45,760 --> 00:10:50,280 +this book the important of this book considering + +141 +00:10:50,280 --> 00:10:53,620 +that the people or the students they have very + +142 +00:10:53,620 --> 00:10:56,280 +little and the little experience in economic and + +143 +00:10:56,280 --> 00:11:01,090 +accountingهو مثلًا تحاول ان تتعامل معك في الاقتصاد + +144 +00:11:01,090 --> 00:11:06,190 +و الاستخدام خطوة بعد خطوة وهو الطريقة الأمريكية + +145 +00:11:06,190 --> 00:11:08,810 +وهي مختلفة من الطريقة البريطانية لأن الطريقة + +146 +00:11:08,810 --> 00:11:12,410 +البريطانية تعتبر أن الطلاب يمتلك فهم فهم فهم فهم + +147 +00:11:12,410 --> 00:11:13,970 +فهم فهم فهم فهم فهم فهم فهم فهم فهم فهم فهم فهم + +148 +00:11:13,970 --> 00:11:13,990 +فهم فهم فهم فهم فهم فهم فهم فهم فهم فهم فهم فهم + +149 +00:11:13,990 --> 00:11:15,210 +فهم فهم فهم فهم فهم فهم فهم فهم فهم فهم فهم فهم + +150 +00:11:15,210 --> 00:11:17,810 +فهم فهم فهم فهم فهم فهم فهم فهم فهم فهم فهم فهم + +151 +00:11:17,810 --> 00:11:22,410 +فهم فهم فهم فهم فهم فهمأنا لا أرغب أن أقول أن آخر + +152 +00:11:22,410 --> 00:11:31,030 +مقالة من كتاب آخر كانت مبنيه على مرحلة صالحة في + +153 +00:11:31,030 --> 00:11:36,710 +الاقتصادي وأسعار الاقتصادي وهذا الكتاب فقط يساعدك + +154 +00:11:36,710 --> 00:11:39,770 +في فهم الاقتصادي وأسعار الاقتصادي + +155 +00:11:45,150 --> 00:11:48,870 +أرجوك للمستخدمين اللي يتكلم عن الهاتف يوجد بعض + +156 +00:11:48,870 --> 00:11:52,490 +الأشياء الاثيقالية في الدراسة تعالي على وقتك يا + +157 +00:11:52,490 --> 00:11:57,350 +عزيزي إنه مهم و سأقوم + +158 +00:11:57,350 --> 00:12:01,910 +بتدخل نقطة المشاركة كل مرة أراك تكتب أو تستخدم + +159 +00:12:01,910 --> 00:12:05,610 +هاتفك لأنني + +160 +00:12:05,610 --> 00:12:11,710 +وضعت هاتفي على مقعدي لذا أعتقد أنك أكتر مهم مني + +161 +00:12:11,710 --> 00:12:16,910 +لذا أرجوbe humble and put your mobile on you + +162 +00:12:16,910 --> 00:12:22,730 +switch it off okay يعني انا بعتقد ان انتوا اهم مني + +163 +00:12:22,730 --> 00:12:25,970 +بكتير فعشان هيك لان انا مش مهم كتير حطيت ال mobile + +164 +00:12:25,970 --> 00:12:30,470 +في الشنطة ف please كونوا متواضعين معايا و حطوا + +165 +00:12:30,470 --> 00:12:33,310 +موبايلاتكم switch it off or keep it silent in your + +166 +00:12:33,310 --> 00:12:38,310 +bags because if I saw you or if I see you texting + +167 +00:12:38,310 --> 00:12:43,310 +it means you underestimate me you know this + +168 +00:12:47,600 --> 00:12:52,400 +please leave it off in your bag handouts the + +169 +00:12:52,400 --> 00:12:56,100 +handouts please print the week's handout هذا ليش + +170 +00:12:56,100 --> 00:13:01,140 +أنا الصبح بدأت to see print the week's handout + +171 +00:13:01,140 --> 00:13:04,020 +before you coming to the class and bring them with + +172 +00:13:04,020 --> 00:13:08,860 +you جيبهم معاك don't leave it at your mom bring it + +173 +00:13:08,860 --> 00:13:12,040 +with you because sometimes if you don't understand + +174 +00:13:12,040 --> 00:13:17,550 +something you just write on the marginأو في بعض + +175 +00:13:17,550 --> 00:13:20,390 +الأحيان يمكنك أن تسألني بعض الأسئلة، فاكتشف فقط + +176 +00:13:20,390 --> 00:13:25,510 +السؤال وإذا كان لديك فرصة لتسأل هذه السؤالة، + +177 +00:13:25,510 --> 00:13:32,950 +فيمكنك أن تسألها و أرجو و أرجو و أرجو أن تحضر + +178 +00:13:32,950 --> 00:13:37,170 +كالكولاتور علمي معك، لأنك لا يمكنك أن تستخدم + +179 +00:13:37,170 --> 00:13:38,230 +موبايلك + +180 +00:13:40,380 --> 00:13:44,640 +انت ممنوع تستخدم موبايلك في المدرسة أو في التجارة + +181 +00:13:44,640 --> 00:13:49,260 +ايضا انا اعرف بعض المدرسين انهم لديهم موبايل لكسر + +182 +00:13:49,260 --> 00:13:54,880 +جدا و هم يحبون ان يبقوا موبايلهم معاهم لذا ارجو في + +183 +00:13:54,880 --> 00:13:59,620 +هذه الوقت ابقى بعيدا لساعة واحدة في موبايلك و لا + +184 +00:13:59,620 --> 00:14:04,040 +تستخدمه كمساعدة احضر المساعدة معك حسنا اذا هذا ما + +185 +00:14:04,040 --> 00:14:10,780 +.. اي سؤال مرتبط بالمدرسة؟ لا شيء؟ حسناthank you + +186 +00:14:10,780 --> 00:14:13,580 +very much and we will carry on in chapter one + +187 +00:14:13,580 --> 00:14:19,220 +suppliers as a student as I'm treated you nicely + +188 +00:14:19,220 --> 00:14:21,880 +during the course you should treated me nicely at + +189 +00:14:21,880 --> 00:14:24,760 +the end of the course by submitted a good + +190 +00:14:24,760 --> 00:14:29,720 +assignment again the problem was our students + +191 +00:14:29,720 --> 00:14:34,100 +think or thought that their teachers are not + +192 +00:14:34,100 --> 00:14:38,740 +reading their assignments which which this is this + +193 +00:14:38,740 --> 00:14:45,310 +is problemهذه السبب ان انا اختار 10 مرات من + +194 +00:14:45,310 --> 00:14:53,570 +الوصفات لذلك اصبح 10% ثم 50% سنتحدث عن هذا اذا + +195 +00:14:53,570 --> 00:14:58,270 +وعدتني ان انا افعل وصفة صحيحه سأفعلها 20% اذا كنت + +196 +00:14:58,270 --> 00:15:06,170 +سعيد بذلك فهي حسنة اذا كنت سعيد بذلك فهي حسنة اذا + +197 +00:15:06,170 --> 00:15:06,650 +كنت سعيد بذلك فهي حسنة اذا كنت سعيد بذلك فهي حسنة + +198 +00:15:06,650 --> 00:15:10,970 +اذا كنت سعيد بذلك فهي حسنةلذا إذا كانت 20% عليك أن + +199 +00:15:10,970 --> 00:15:21,790 +تعدني أنا حذرا جدا في قراءة مهمتك ماذا + +200 +00:15:21,790 --> 00:15:27,270 +تعتقد؟ 10% أو .. حسنا فقط ارفع يديك 10% حسنا دعنا + +201 +00:15:27,270 --> 00:15:33,260 +نتحدث أولا حسنا دعنا نحاول أن نثبتهملا من الأول + +202 +00:15:33,260 --> 00:15:39,240 +نشوف how is your assignment okay so leave it as as + +203 +00:15:39,240 --> 00:15:44,800 +it is then we will decide okay that's fine do you + +204 +00:15:44,800 --> 00:15:48,360 +agree with with her yes okay so we will leave this + +205 +00:15:48,360 --> 00:15:54,540 +we will negotiate this after the midterm exam okay + +206 +00:15:54,540 --> 00:15:57,520 +we will discuss this after the midterm exam if you + +207 +00:15:57,520 --> 00:16:02,150 +are happy with my markingأنا لا أتكلم عن مرحلة + +208 +00:16:02,150 --> 00:16:06,230 +الوظيفة، أنا أتكلم عن مرحلة الوظيفة لذلك يمكننا أن + +209 +00:16:06,230 --> 00:16:12,010 +نتناقض أو نقول حسنًا 10% و نستطيع أن نتحرك إلى 20% + +210 +00:16:12,010 --> 00:16:20,250 +حسنًا، هذه مشاكل جيدة و بوليتيكية جيدة، لذلك يا + +211 +00:16:20,250 --> 00:16:23,910 +عزيزي فاهموا الولايات المتحدة؟ هل أنت مرتاحة مع + +212 +00:16:23,910 --> 00:16:30,670 +علاقات المستخدمين؟هو أشياء جديدة لك او كنت تعرف + +213 +00:16:30,670 --> 00:16:36,090 +عنها؟ انت تقبل علاقات مصادر المصادر بالنسبة لتعامل + +214 +00:16:36,090 --> 00:16:43,530 +استراتيجي؟ انا كتابة و أنا طلاب كمصادر و كمصادر + +215 +00:16:43,530 --> 00:16:49,390 +نعرف هذا نعرف هذا انا كتابة و انا طلاب و انا مصادر + +216 +00:16:50,200 --> 00:16:56,360 +هو للمرة الأولى، لكن كيف أتيت العلاقة بين العاملين + +217 +00:16:56,360 --> 00:17:04,760 +والمديرين؟ من هو المستخدم ومن هو المصادر؟ نعم، + +218 +00:17:04,760 --> 00:17:09,820 +فأفكر بهذه الطريقة، أنت ومامك، يمكن أن تكون علاقة + +219 +00:17:09,820 --> 00:17:15,180 +مستخدم ومصادر، فهو يعني أنه يتفكير هذه الفهمة في + +220 +00:17:15,180 --> 00:17:17,640 +حياتك الحقيقية، في حياتك العمل، + +221 +00:17:19,580 --> 00:17:23,660 +يعطيك عمل صحيح وهو السبب انه يسمى Quality + +222 +00:17:23,660 --> 00:17:30,640 +Management في الوقت نفسه؟ ليس في الوقت نفسه الان + +223 +00:17:30,640 --> 00:17:38,200 +انا انا المصطلح لان انا مصطلح الوضع لك وانت الآن + +224 +00:17:38,200 --> 00:17:43,980 +مصطلح الوضع في التجارة او التجارة انت مصطلح وانا + +225 +00:17:43,980 --> 00:17:51,680 +مصطلح هذا هو الامرwhen you are writing your exam + +226 +00:17:51,680 --> 00:17:55,580 +be careful there is somebody on this universe + +227 +00:17:55,580 --> 00:17:59,540 +reading your assignments you should make them to + +228 +00:17:59,540 --> 00:18:02,480 +enjoy in reading your assignment not just okay + +229 +00:18:02,480 --> 00:18:07,050 +this is rubbish leave it hereit's like invite them + +230 +00:18:07,050 --> 00:18:09,750 +to read sometimes you have a good piece of + +231 +00:18:09,750 --> 00:18:13,110 +knowledge on your assignment but the problem is + +232 +00:18:13,110 --> 00:18:18,210 +you have a bad presenting your knowledge as a + +233 +00:18:18,210 --> 00:18:21,130 +quality management you have to present them nicely + +234 +00:18:21,130 --> 00:18:24,350 +and looking after many things when you are + +235 +00:18:24,350 --> 00:18:27,790 +presenting things okay now let's talk about + +236 +00:18:27,790 --> 00:18:32,800 +chapter one any comments before startingبالتأكيد، + +237 +00:18:32,800 --> 00:18:40,500 +الكتاب المتوفر في مزارة أفاق، فهو متوفر حسنا، + +238 +00:18:40,500 --> 00:18:47,540 +دعونا نبدأ من القصة الأولى كما + +239 +00:18:47,540 --> 00:18:55,520 +قلت في الانتقال للخدمة، القصة الأولى تعطيك بعض + +240 +00:18:55,520 --> 00:19:01,050 +الأساس والقواعد الخدمةوخصوصًا يجيب على السؤال + +241 +00:19:01,050 --> 00:19:06,990 +لماذا ندرس التخزين؟ وما هي المناطق التي تحتاجها + +242 +00:19:06,990 --> 00:19:14,910 +التخزين؟ هذا هو نقطة البداية لنا دعونا نرى المحتوى + +243 +00:19:14,910 --> 00:19:19,630 +الصحيح لدينا المهارات التعليمية ثم الانتقال + +244 +00:19:19,630 --> 00:19:25,610 +والمقالات المهمةسنتحدث عن مهارات التعليم، تقريبًا، + +245 +00:19:25,610 --> 00:19:28,870 +سنتحدث عن التعليم، تقريبًا، تقريبًا، تقريبًا، + +246 +00:19:28,870 --> 00:19:29,150 +تقريبًا، تقريبًا، تقريبًا، تقريبًا، تقريبًا، + +247 +00:19:29,150 --> 00:19:29,930 +تقريبًا، تقريبًا، تقريبًا، تقريبًا، تقريبًا، + +248 +00:19:29,930 --> 00:19:30,570 +تقريبًا، تقريبًا، تقريبًا، تقريبًا، تقريبًا، + +249 +00:19:30,570 --> 00:19:42,030 +تقريبًا، تقريبًا، تقريبًا، تقريبًا، + +250 +00:19:42,030 --> 00:19:49,450 +تقوالانتقال ومعرفة التعامل، ثلاثة أسلوب مؤسسات مثل + +251 +00:19:49,450 --> 00:19:53,370 +الـ Sold Proprietorship والمشاركات والمؤسسات + +252 +00:19:53,370 --> 00:20:00,430 +والمؤسسات والمشاركات والمؤسسات ومشاركات + +253 +00:20:00,430 --> 00:20:01,210 +ومشاركات ومشاركات ومشاركات ومشاركات ومشاركات + +254 +00:20:01,210 --> 00:20:01,310 +ومشاركات ومشاركات ومشاركات ومشاركات ومشاركات + +255 +00:20:01,310 --> 00:20:10,330 +ومشاركات ومشاركات ومشاركات ومشاركات ومشارك + +256 +00:20:12,010 --> 00:20:16,690 +Learning Objectives نحن نهتم في هذه القصة بالفهم + +257 +00:20:16,690 --> 00:20:20,330 +عن مهمة الانتجار في كلا الأماكن في حياتك الشخصية + +258 +00:20:20,330 --> 00:20:25,850 +وفي حياتك الوظيفة حياتك الشخصية يعني عندما تتعامل + +259 +00:20:25,850 --> 00:20:30,610 +مع الناس في مستوى شخصيك على سبيل المثال إذا كان + +260 +00:20:30,610 --> 00:20:34,530 +لديك 100 دولار كيف تستخدم 100 دولار في حياتك + +261 +00:20:34,530 --> 00:20:42,110 +الشخصية كيف تقوم بتقاطهم؟وفي حياتك المستخدمة، يعني + +262 +00:20:42,110 --> 00:20:45,690 +عندما تتعامل مع قرارات الاستثمار، كيف تقوم + +263 +00:20:45,690 --> 00:20:49,950 +بتقليلهم أو كيف تقوم بتقليل هذه المستخدمات؟ عندما + +264 +00:20:49,950 --> 00:20:55,470 +نتحدث عن المستخدم، المستخدم يهتم في إنتاج أو إعادة + +265 +00:20:55,470 --> 00:21:02,070 +الوالدة، ولكن في حياتك المستخدمة، هي كيف تناسب هذه + +266 +00:21:02,070 --> 00:21:06,810 +المال لتجعل الحياة أكثر مناسبة، انت لا تهتم في + +267 +00:21:06,810 --> 00:21:11,180 +إجراء نفعWhen you are spending your money on + +268 +00:21:11,180 --> 00:21:13,700 +foods, it doesn't mean you are generating profits + +269 +00:21:14,600 --> 00:21:17,920 +Okay, so it's what's how much you spend in foods, + +270 +00:21:18,040 --> 00:21:20,120 +how much you spend in tourists, how much you spend + +271 +00:21:20,120 --> 00:21:24,840 +in this is like how to structure you or divide + +272 +00:21:24,840 --> 00:21:29,380 +your business, your money. And professional lives + +273 +00:21:29,380 --> 00:21:31,960 +and identify the three primary business decisions, + +274 +00:21:32,920 --> 00:21:35,580 +three primary business decisions, how to get the + +275 +00:21:35,580 --> 00:21:38,240 +funds, how to invest the funds and how to fund + +276 +00:21:38,240 --> 00:21:41,720 +this. We will go back to this point and find the + +277 +00:21:41,720 --> 00:21:43,900 +key differences between three major legal forms of + +278 +00:21:43,900 --> 00:21:48,530 +business.ما هي الفرق بين الـ SoulTrader والمشاركات + +279 +00:21:48,530 --> 00:21:57,470 +والمؤسسات؟ ويجب أن تعطينا مثال عن هذه الشركات افهم + +280 +00:21:57,470 --> 00:22:01,310 +رولة الرئيس المالي، إذا كنت رئيس مالي، ما هي + +281 +00:22:01,310 --> 00:22:07,290 +مفروضاتك وما هي مهمة الرئيس المالي؟ ثم اشرح ال 4 + +282 +00:22:07,290 --> 00:22:08,150 +أساسي المال + +283 +00:22:11,420 --> 00:22:13,740 +Can you give me examples of financial decisions + +284 +00:22:13,740 --> 00:22:15,340 +faced in your probation? + +285 +00:22:18,020 --> 00:22:24,020 +In this introduction you should know financial + +286 +00:22:24,020 --> 00:22:28,460 +decisions, this is like ice break question just to + +287 +00:22:28,460 --> 00:22:32,360 +see to what extent you understand finance Can you + +288 +00:22:32,360 --> 00:22:36,180 +give me examples of any financial decision in your + +289 +00:22:36,180 --> 00:22:40,300 +personal life or in your professional life?Can you + +290 +00:22:40,300 --> 00:22:48,560 +give me any example؟ if you want to buy a car you + +291 +00:22:48,560 --> 00:22:51,940 +have just only one alternative to buy a car or to + +292 +00:22:51,940 --> 00:22:58,160 +not buying a car okay so these are investment + +293 +00:22:58,160 --> 00:23:02,140 +alternatives you have two alternatives is buying a + +294 +00:23:02,140 --> 00:23:07,320 +car or not buying a carهذه اختيارات مالية مشابهة + +295 +00:23:07,320 --> 00:23:13,260 +لشركة تشتر أو لا تشتر اشركة او مشابهة لشركة تشتر + +296 +00:23:13,260 --> 00:23:19,840 +لتصنع المجالات او تشتر الناس لتصنع المجالات لديك + +297 +00:23:19,840 --> 00:23:25,860 +مجالات تشتر او لديك مجالات تشتر او لديك مجالات + +298 +00:23:25,860 --> 00:23:29,200 +تشتر او لديك مجالات تشتر او لديك مجالات تشتر او + +299 +00:23:29,200 --> 00:23:29,500 +لديك مجالات تشتر او لديك مجالات تشتر او لديك + +300 +00:23:29,500 --> 00:23:35,820 +تشتر او لديك مجالات تشتر او لديك مجالاتhow I spend + +301 +00:23:35,820 --> 00:23:42,120 +it or I keep it or spend it okay so this is the + +302 +00:23:42,120 --> 00:23:46,360 +personal decision what other if someone wants to + +303 +00:23:46,360 --> 00:23:51,120 +buy a land or he wants to invest the money okay + +304 +00:23:51,120 --> 00:23:55,280 +buying a land or buying a real estate or for + +305 +00:23:55,280 --> 00:24:01,810 +instance starting a businessأو انتقل ماله في هذا + +306 +00:24:01,810 --> 00:24:06,690 +أو .. حسنا هذا يعني أنك تركز على نوع واحد من + +307 +00:24:06,690 --> 00:24:10,670 +القرارات مثل كيف تقوم بالاستثمار أو أين تقوم + +308 +00:24:10,670 --> 00:24:16,250 +بالاستثمار؟ كيف تقوم بالاستثمار؟ + +309 +00:24:16,250 --> 00:24:18,130 +كيف تقوم بالاستثمار؟ كيف تقوم بالاستثمار؟ كيف تقوم + +310 +00:24:18,130 --> 00:24:18,530 +بالاستثمار؟ كيف تقوم بالاستثمار؟ كيف تقوم + +311 +00:24:18,530 --> 00:24:20,370 +بالاستثمار؟ كيف تقوم بالاستثمار؟ كيف تقوم + +312 +00:24:20,370 --> 00:24:27,870 +بالاستثمار؟ كيف تقوم بالاستثمار؟ كيف + +313 +00:24:27,870 --> 00:24:28,010 +تقوم بالاست + +314 +00:24:32,850 --> 00:24:38,070 +yes so it's like fund how to to get money or how + +315 +00:24:38,070 --> 00:24:41,230 +to get fund from the other alternatives it's like + +316 +00:24:41,230 --> 00:24:44,650 +you are talking some some students asking or + +317 +00:24:44,650 --> 00:24:47,750 +saying the other alternatives that's available to + +318 +00:24:47,750 --> 00:24:51,090 +the to the to the person to invest as as you said + +319 +00:24:51,090 --> 00:24:55,280 +you you asking from where you get the fundمن + +320 +00:24:55,280 --> 00:25:00,400 +الاحتياطات من المساعدات وما إلى ذلك، حسنا؟ هذه + +321 +00:25:00,400 --> 00:25:07,620 +مثالات عن الاختيارات المالية دعونا + +322 +00:25:07,620 --> 00:25:12,480 +نبدأ بالتجارب المالية، ماذا هي التجارب المالية؟ + +323 +00:25:12,480 --> 00:25:19,840 +ماذا هي التجارب المالية؟ حاول أن تقرأ هذا وانتقل + +324 +00:25:19,840 --> 00:25:24,120 +ما هو الاختصار أو ماذا بالضبط يعني التجارب المالية + +325 +00:25:36,230 --> 00:26:00,270 +take one to two minutes okay + +326 +00:26:00,270 --> 00:26:02,190 +so what is finance + +327 +00:26:05,090 --> 00:26:09,990 +انت فقط لديك اتصالين او اتصالين و نصف ولكن لتفهم + +328 +00:26:09,990 --> 00:26:18,090 +هذا يحتاج الهاردوريك انت + +329 +00:26:18,090 --> 00:26:26,310 +تبدأ بإزالة مصادر مصادر مصادر مصادر مصادر مصادر + +330 +00:26:26,310 --> 00:26:27,950 +مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر + +331 +00:26:27,950 --> 00:26:28,350 +مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر + +332 +00:26:28,350 --> 00:26:28,370 +مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر + +333 +00:26:28,370 --> 00:26:28,390 +مصادر مصادر مصادر مصادر مصادر مصادر مصادر مصادر + +334 +00:26:28,390 --> 00:26:32,230 +مصادر مصادر مصادر مصادر مصادر + +335 +00:26:32,230 --> 00:26:33,350 +مص + +336 +00:26:35,970 --> 00:26:39,770 +رقم المال لماذا نحصل على المال لماذا نحتاج المال + +337 +00:26:39,770 --> 00:26:48,850 +نبدأ برقم المال أو بشيء آخر فهو مهتم بالعمل لتحقيق + +338 +00:26:48,850 --> 00:26:57,510 +الprofit هذا هو مهتم بالعمل أنت محق هذا + +339 +00:26:57,510 --> 00:27:00,950 +مرة + +340 +00:27:00,950 --> 00:27:07,270 +أخرى كما قالت هذا هو المهتمينولكن ليس التخزين هذا + +341 +00:27:07,270 --> 00:27:11,730 +هدف المهتم بالتخزين نعم انت محق إذا كنا نتكلم عن + +342 +00:27:11,730 --> 00:27:16,970 +ماذا هي مهتمتنا لكن ماذا بالضبط التخزين؟ لأننا + +343 +00:27:16,970 --> 00:27:19,610 +نفعل هذا ونفعل هذا ونفعل هذا ونفعل هذا ونفعل هذا + +344 +00:27:19,610 --> 00:27:19,730 +ونفعل هذا ونفعل هذا ونفعل هذا ونفعل هذا ونفعل هذا + +345 +00:27:19,730 --> 00:27:20,290 +ونفعل هذا ونفعل هذا ونفعل هذا ونفعل هذا ونفعل هذا + +346 +00:27:20,290 --> 00:27:21,350 +ونفعل هذا ونفعل هذا ونفعل هذا ونفعل هذا ونفعل هذا + +347 +00:27:21,350 --> 00:27:25,470 +ونفعل هذا ونفعل هذا + +348 +00:27:25,470 --> 00:27:32,190 +ونفعل + +349 +00:27:33,550 --> 00:27:38,490 +الأول هو أننا لدينا إستثمارات إستثمارات إستثمارات + +350 +00:27:38,490 --> 00:27:44,850 +إستثمارات إستثمارات إستثمارات + +351 +00:27:44,850 --> 00:27:51,010 +إستثمارات إستثمارات إستثمارات إستثمارات إستثمارات + +352 +00:27:51,010 --> 00:27:52,330 +إستثمارات إستثمارات إستثمارات إستثمارات إستثمارات + +353 +00:27:52,330 --> 00:28:02,890 +إستثمارات إستثمارات إستثمارات إستثمارات إستثمارات + +354 +00:28:03,850 --> 00:28:12,770 +لتثق بمالنا في A أو في B أو في C يجب أن تقرر من + +355 +00:28:12,770 --> 00:28:19,130 +النظر المالي اذا كنت تقرر تثق في A, B أو C؟ على + +356 +00:28:19,130 --> 00:28:23,630 +سبيل المثال، مجلس التسويق يقرر تحسين السوق، هذا + +357 +00:28:23,630 --> 00:28:28,670 +حسن، ما هي التغييرات للعمل هذا؟مثلًا، الأولى + +358 +00:28:28,670 --> 00:28:37,390 +التانية هي الانتجار لشركة تسويس جديدة والثانية + +359 +00:28:37,390 --> 00:28:42,470 +التانية هي القيامة والثالثة التانية مثلًا هي + +360 +00:28:42,470 --> 00:28:48,470 +الانتجار للشركات التي تسوي + +361 +00:28:48,470 --> 00:28:51,850 +السوق لذلك لدينا ثلاثة تانية تانية تانية تانية + +362 +00:28:51,850 --> 00:28:54,250 +تانية تانية تانية تانية تانية تانية تانية تانية + +363 +00:28:54,250 --> 00:28:54,930 +تانية تانية تانية تانية تانية تانية تانية تانية + +364 +00:28:54,930 --> 00:28:55,070 +تانية تانية تانية تانية تانية تانية تانية تانية + +365 +00:28:55,070 --> 00:28:55,170 +تانية تانية تانية تانية تانية تانية تانية تانية + +366 +00:28:55,170 --> 00:28:58,960 +تانية تانية تانية تانيةالخدمات الاجتماعية لديها + +367 +00:28:58,960 --> 00:29:04,940 +خيار الأخير لأنه في نهاية اليوم تدفع المال إلى هذه + +368 +00:29:04,940 --> 00:29:09,600 +المشروعات لذلك لدينا ثلاثة إستخدامات A, B أو C + +369 +00:29:09,600 --> 00:29:12,640 +نحفظهم + +370 +00:29:12,640 --> 00:29:20,920 +كما ترى هنا كيف يحفظ الناس و المشروعات نحفظ هذه + +371 +00:29:20,920 --> 00:29:29,280 +الفرصة و نستطيع الذهاب إلى Bإذا قررنا على B نحتاج + +372 +00:29:29,280 --> 00:29:36,300 +إلى كابيتل وانتبهوا عندما نقول كابيتل لا يعني أمرا + +373 +00:29:36,300 --> 00:29:43,020 +كابيتل ليس أمرا لماذا؟ لأنه من المنصب التحقيقي + +374 +00:29:43,020 --> 00:29:47,620 +وكما قلت من قبل هذا هو التحقيق T هى المواصفات + +375 +00:29:47,620 --> 00:29:51,840 +الحالية هي المواصفات الحالية وهي المواصفات + +376 +00:29:51,840 --> 00:29:54,940 +والمواصفات والمواصفات والمواصفات والمواصفات + +377 +00:29:54,940 --> 00:30:01,520 +والمواصفاتهذه المنطقة الأسفل هي المصادر وهذه + +378 +00:30:01,520 --> 00:30:07,620 +المنطقة هنا هي مصادر الانتجار لا تنسى + +379 +00:30:07,620 --> 00:30:14,300 +هذا وهذه المنطقة هي مصادر الانتجار هذه + +380 +00:30:14,300 --> 00:30:22,900 +المنطقة في الجهة اليسارك هي المصادر وهذه + +381 +00:30:22,900 --> 00:30:27,600 +المنطقة هي مصادر الانتجارالسياسة المالية تعني إذا + +382 +00:30:27,600 --> 00:30:33,940 +كنت تعتمد على او تعتمد على المال او تعتمد على + +383 +00:30:33,940 --> 00:30:40,440 +المال اذا + +384 +00:30:40,440 --> 00:30:45,760 +مرة أخرى اندريس كابيتل اعزز أي جزء؟ هذا الجزء او + +385 +00:30:45,760 --> 00:30:52,380 +هذا الجزء؟ هذا الجزء نحن نتكلم عن هذا الجزء من أين + +386 +00:30:52,380 --> 00:30:58,240 +نحصل الكابيتل؟تتعامل مع شركات مشهورة او تدفع المال + +387 +00:30:58,240 --> 00:31:04,340 +من البنك يجب ان تقرر ان تدفع المال من البنك تدفع + +388 +00:31:04,340 --> 00:31:05,860 +المال من البنك تدفع المال من البنك تدفع المال من + +389 +00:31:05,860 --> 00:31:05,940 +المال من البنك تدفع المال من البنك تدفع المال من + +390 +00:31:05,940 --> 00:31:07,760 +البنك تدفع المال من البنك تدفع المال من البنك تدفع + +391 +00:31:07,760 --> 00:31:08,980 +المال من البنك تدفع المال من البنك تدفع المال من + +392 +00:31:08,980 --> 00:31:09,280 +البنك تدفع المال من البنك تدفع المال من البنك تدفع + +393 +00:31:09,280 --> 00:31:13,680 +المال من البنك تدفع المال من البنك تدفع المال من + +394 +00:31:13,680 --> 00:31:15,460 +البنك + +395 +00:31:24,550 --> 00:31:30,330 +الحصة الحالية حسنا في المستخدمات هل تعتقد أن + +396 +00:31:30,330 --> 00:31:35,170 +المستخدمات مستخدمات مستخدمات مستخدمات مستخدمات + +397 +00:31:35,170 --> 00:31:35,510 +مستخدمات مستخدمات مستخدمات مستخدمات مستخدمات + +398 +00:31:35,510 --> 00:31:36,150 +مستخدمات مستخدمات مستخدمات مستخدمات مستخدمات + +399 +00:31:36,150 --> 00:31:37,290 +مستخدمات مستخدمات مستخدمات مستخدمات مستخدمات + +400 +00:31:37,290 --> 00:31:39,650 +مستخدمات مستخدمات مستخدمات مستخدمات مستخدمات + +401 +00:31:39,650 --> 00:31:39,690 +مستخدمات مستخدمات مستخدمات مستخدمات مستخدمات + +402 +00:31:39,690 --> 00:31:39,770 +مستخدمات مستخدمات مستخدمات مستخدمات مستخدمات + +403 +00:31:39,770 --> 00:31:45,010 +مستخدمات مستخدمات مستخدمات مستخدمات مستخدمات + +404 +00:31:45,010 --> 00:31:51,510 +مست + +405 +00:31:51,750 --> 00:31:53,950 +الشركات الموجودة في هذه المواصفات في الواقع + +406 +00:31:53,950 --> 00:31:56,690 +التعليمي I know you know the components of the + +407 +00:31:56,690 --> 00:31:58,970 +current asset and the component of the fixed asset + +408 +00:31:58,970 --> 00:32:02,970 +and the other areas of accounting بقى is how to + +409 +00:32:02,970 --> 00:32:07,390 +manage this to understand the functions of each + +410 +00:32:07,390 --> 00:32:10,270 +component it needs some understanding some + +411 +00:32:10,270 --> 00:32:16,020 +knowledge in financeهذه المنطقة هي أساسية المال من + +412 +00:32:16,020 --> 00:32:21,080 +أين يأتي المال وهذه المنطقة كيف نستخدمه أو أين + +413 +00:32:21,080 --> 00:32:27,100 +نستخدم مالنا؟ نستخدم مالنا في أساتذ مخصصة أو + +414 +00:32:27,100 --> 00:32:33,000 +نستخدم مالنا في بعض الأشياء المحفظة وأشياء أخرى، + +415 +00:32:33,000 --> 00:32:39,160 +فأنت ترى هذه الأشياء الصغيرةأعطوني صورة عبارة عن + +416 +00:32:39,160 --> 00:32:45,240 +ما هو الانبعاث لكي تفهم ما هو الانبعاث يجب أن تعرف + +417 +00:32:45,240 --> 00:32:51,400 +عن استخدام الاستثمار أو فرصة الاستثمار و لدينا + +418 +00:32:51,400 --> 00:32:57,940 +آلاف فرص موفقة في حياتنا ثم الشيء الثاني هو أن + +419 +00:32:57,940 --> 00:33:03,020 +تعرف كيف تنزل هذا المكان هذا المال لديك العديد من + +420 +00:33:03,020 --> 00:33:08,960 +التغييرات أيضًا ثم كيف تستخدم هذاكما تعرفين من + +421 +00:33:08,960 --> 00:33:13,500 +وجهة الوصفة، تعرفين أن هذا مصدر المال و تعرفين أن + +422 +00:33:13,500 --> 00:33:19,580 +هذا استخدام المال، هل هذا صح؟ هذا مصدر المال و هذا + +423 +00:33:19,580 --> 00:33:26,960 +استخدام المال، مصدر المال هو من أين يأتي المال و + +424 +00:33:26,960 --> 00:33:33,740 +من هنا أين يذهب المال، نحضره من هنا و ندفعه هنا + +425 +00:33:34,790 --> 00:33:41,530 +بالنسبة للمستخدم، هذه المنطقة ممتازة في إصلاح + +426 +00:33:41,530 --> 00:33:45,100 +الأموالهذه المنطقة هذا هو السبب في اسمها + +427 +00:33:45,100 --> 00:33:50,020 +Investment هذه المنطقة ليست مخصصة في إجراء أرباح + +428 +00:33:50,020 --> 00:33:55,860 +لأن المشركات اللي موجودة هنا مخصصة في إنتاج خدمات + +429 +00:33:55,860 --> 00:33:59,940 +ومساعدات إذا كانت هذه المشركات قادرة على إنتاج + +430 +00:33:59,940 --> 00:34:03,780 +أشياء فإنها يعني أننا لا نستطيع إجراء شركات وشركات + +431 +00:34:03,780 --> 00:34:07,960 +لا نستطيع إنتاج مال ومن ثم لا نكون لدينا أرباح هل + +432 +00:34:07,960 --> 00:34:14,550 +رأيت هذه القصة؟ قصة طويلة؟ فقط من القليلالصورة إذا + +433 +00:34:14,550 --> 00:34:19,790 +وضعت في عقلك هذه الفهمية عن المشروع كيف هي التخزين + +434 +00:34:19,790 --> 00:34:27,850 +مثل مخدرات موجودة في كل مكان لأنها مثل إعادة توقف + +435 +00:34:27,850 --> 00:34:36,810 +لكل شخص لأن إذا لم تكن لديك تحسينات مستخدمية لعمل + +436 +00:34:36,810 --> 00:34:38,550 +عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل + +437 +00:34:38,550 --> 00:34:39,030 +عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل + +438 +00:34:39,030 --> 00:34:39,090 +عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل + +439 +00:34:39,090 --> 00:34:39,130 +عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل عمل + +440 +00:34:39,130 --> 00:34:43,070 +عمل عمل عمل عمل عمل عمل عمل عمل عمل عأفضل استخدام + +441 +00:34:43,070 --> 00:34:43,810 +استخدام استخدام استخدام استخدام استخدام استخدام + +442 +00:34:43,810 --> 00:34:45,890 +استخدام استخدام استخدام استخدام استخدام استخدام + +443 +00:34:45,890 --> 00:34:47,950 +استخدام استخدام استخدام استخدام استخدام استخدام + +444 +00:34:47,950 --> 00:34:49,850 +استخدام استخدام استخدام استخدام استخدام استخدام + +445 +00:34:49,850 --> 00:34:50,430 +استخدام استخدام استخدام استخدام استخدام استخدام + +446 +00:34:50,430 --> 00:34:56,110 +استخدام استخدام استخدام استخدام استخدام استخدام + +447 +00:34:56,110 --> 00:34:58,090 +استخدام استخدام استخدام استخدام استخدام استخدام + +448 +00:34:58,090 --> 00:35:01,110 +استخدام + +449 +00:35:17,830 --> 00:35:24,410 +الان اعتقد انك تعرفين لماذا نقرر + +450 +00:35:24,410 --> 00:35:25,850 +اننا نقرر اننا نقرر اننا نقرر اننا نقرر اننا نقرر + +451 +00:35:25,850 --> 00:35:28,830 +اننا نقرر اننا نقرر اننا نقرر اننا نقرر اننا نقرر + +452 +00:35:28,830 --> 00:35:29,250 +اننا نقرر اننا نقرر اننا نقرر اننا نقرر اننا نقرر + +453 +00:35:29,250 --> 00:35:46,090 +اننا نقرر اننا نقرر اننا نقرر اننا نقرر اننا + +454 +00:35:46,090 --> 00:35:53,880 +نالثلاث أسئلة تتعلق بالدراسة عن المال أولا ماهي + +455 +00:35:53,880 --> 00:35:56,560 +المستخدمات المستخدمة المستخدمة المستخدمة المستخدمة + +456 +00:35:56,560 --> 00:35:58,160 +المستخدمة المستخدمة المستخدمة المستخدمة المستخدمة + +457 +00:35:58,160 --> 00:36:02,100 +المستخدمة المستخدمة المستخدمة المستخدمة المستخدمة + +458 +00:36:02,100 --> 00:36:02,400 +المستخدمة المستخدمة المستخدمة المستخدمة المستخدمة + +459 +00:36:02,400 --> 00:36:02,620 +المستخدمة المستخدمة المستخدمة المستخدمة المستخدمة + +460 +00:36:02,620 --> 00:36:05,080 +المستخدمة المستخدمة المستخدمة المستخدمة المستخدمة + +461 +00:36:05,080 --> 00:36:09,820 +المستخدمة + +462 +00:36:09,820 --> 00:36:17,550 +المستخدمة المستخدمة المستخدمة المستInvest in the + +463 +00:36:17,550 --> 00:36:24,390 +fixed asset needs long term decision okay Invest + +464 +00:36:24,390 --> 00:36:27,710 +.. I think one of students said if the current + +465 +00:36:27,710 --> 00:36:30,890 +asset is investment yes right but this short term + +466 +00:36:30,890 --> 00:36:35,630 +investment okay short term investment so in in + +467 +00:36:35,630 --> 00:36:40,010 +when we talk about the long term investments okay + +468 +00:36:40,010 --> 00:36:45,740 +isيجب أن نتعامل مع هذه السؤال خلال دراساتنا + +469 +00:36:45,740 --> 00:36:50,620 +بالخدمة. في نهاية هذه الدراسة يجب أن نسأل نفسنا + +470 +00:36:50,620 --> 00:36:55,860 +هذه السؤالة ماذا هو أو ما هي الاختيارات طوال الوقت + +471 +00:36:55,860 --> 00:37:03,360 +التي يجب أن ناخدها لكي نحفز حياتنا وهذه الاختيارات + +472 +00:37:03,360 --> 00:37:05,620 +المعروفة بـ Capital Budgeting هل تتذكرين عندما كنت + +473 +00:37:05,620 --> 00:37:09,260 +اكتشف Capital Budgeting؟ نعم تتذكرين هذا فقط تحاول + +474 +00:37:11,770 --> 00:37:15,710 +Complete the picture, see the full picture, okay? + +475 +00:37:16,370 --> 00:37:18,850 +Put the components of this picture together, this + +476 +00:37:18,850 --> 00:37:22,730 +is capital budgeting, this is decisions And the + +477 +00:37:22,730 --> 00:37:25,530 +second, how should the firm fund this investment? + +478 +00:37:26,070 --> 00:37:29,230 +You remember the previous slide, this slide is + +479 +00:37:29,230 --> 00:37:32,210 +related to the F, it's like you are narrating a + +480 +00:37:32,210 --> 00:37:37,540 +storyوكل جزء من القصة مرتبط بالقصة السابقة و القصة + +481 +00:37:37,540 --> 00:37:42,200 +الثانية إذا خسرت أحد جزء من القصة، فهذا يعني أنك + +482 +00:37:42,200 --> 00:37:49,940 +مفهوم، حسنا؟ إنها مثل المعرفة، هذا هو السبب في أن + +483 +00:37:49,940 --> 00:37:53,700 +بعض المدرسات العمل لايحبون أن يدرسوا الانترنت لأن + +484 +00:37:53,700 --> 00:37:59,560 +كل شيء مرتبط بالقصة السابقة و القصة السابقة، لكن + +485 +00:37:59,560 --> 00:38:04,760 +أعتقد أن هذا بسيط جدا، انت فقط تتبعكيف يجب أن + +486 +00:38:04,760 --> 00:38:09,200 +الناس يدفع هذه الدفعات؟ كيف يمكننا أن ندفع هذه + +487 +00:38:09,200 --> 00:38:14,480 +الدفعات؟ من هنا، من المقاومة، فهذه هي المقاومة + +488 +00:38:14,480 --> 00:38:24,020 +ماذا في 1 مليون دولار؟ ماذا في .. و تفكر في + +489 +00:38:24,020 --> 00:38:26,100 +تغييرات مختلفة، على سبيل المثال عندك 1 مليون + +490 +00:38:26,100 --> 00:38:31,580 +دولار، هل تدفع في هذا 1 مليون دولار؟ في حصتك؟ + +491 +00:38:31,580 --> 00:38:32,440 +كلهم؟ + +492 +00:38:34,740 --> 00:38:39,900 +لا قالت بالتأكيد نعم بالتأكيد لا انا لا انا لا انا + +493 +00:38:39,900 --> 00:38:40,260 +لا انا لا انا لا انا لا انا لا انا لا انا لا انا + +494 +00:38:40,260 --> 00:38:42,320 +لا انا لا انا لا انا لا انا لا انا لا انا لا انا + +495 +00:38:42,320 --> 00:38:55,000 +لا انا لا انا لا انا + +496 +00:38:55,000 --> 00:38:55,300 +لا انا لا انا لا انا لا انا لا انا لا انا لا انا + +497 +00:38:55,300 --> 00:38:56,780 +لا انا لا انا لا انا لا انا لا انا لا انا لا انا + +498 +00:38:56,780 --> 00:38:56,820 +لا انا لا انا لا انا لا انا لا انا لا انا لا انا + +499 +00:38:56,820 --> 00:39:01,880 +لا اإذا كان لديك 1 مليون دولار في حصتك، فهو بخير، + +500 +00:39:01,880 --> 00:39:09,320 +يمكنك أن تبدأ بـ500 ألف دولار ويمكنك أن تدفع 500 + +501 +00:39:09,320 --> 00:39:15,620 +ألف دولار من البنك والباقية 500 ألف دولار يمكنك أن + +502 +00:39:15,620 --> 00:39:19,700 +تفتحه في مشروع جديد، فتنتهي منه ب2 مشروع لكن + +503 +00:39:19,700 --> 00:39:26,480 +المشكلة هيإذا لم تنجحوا في إجراء عملكم، في إجراء + +504 +00:39:26,480 --> 00:39:26,820 +عملكم عملكم عملكم عملكم عملكم عملكم عملكم عملكم + +505 +00:39:26,820 --> 00:39:27,440 +عملكم عملكم عملكم عملكم عملكم عملكم عملكم عملكم + +506 +00:39:27,440 --> 00:39:28,860 +عملكم عملكم عملكم عملكم عملكم عملكم عملكم عملكم + +507 +00:39:28,860 --> 00:39:30,020 +عملكم عملكم عملكم عملكم عملكم عملكم عملكم عملكم + +508 +00:39:30,020 --> 00:39:32,060 +عملكم عملكم عملكم عملكم عملكم عملكم عملكم عملكم + +509 +00:39:32,060 --> 00:39:33,300 +عملكم عملكم عملكم عملكم عملكم عملكم عملكم عملكم + +510 +00:39:33,300 --> 00:39:33,840 +عملكم عملكم عملكم عملكم عملكم عملكم عملكم عملكم + +511 +00:39:33,840 --> 00:39:39,820 +عملكم عملكم عملكم عملكم عملكم + +512 +00:39:39,820 --> 00:39:47,890 +عملكم عملكم عملكم عملكم عملكم عملكم عوفي نفس الوقت + +513 +00:39:47,890 --> 00:39:52,490 +أنت تطلب الـ higher return لأنك تبقى 1 مليون دولار + +514 +00:39:52,490 --> 00:39:58,230 +وانت تدفع 1 مليون دولار من المصادر الأخرى، فهذه هي + +515 +00:39:58,230 --> 00:40:02,390 +التغييرات الانتجارية التي تقولها الناس المهمين، + +516 +00:40:02,390 --> 00:40:07,750 +الناس الذكيين، يفكرون بطريقات مختلفة ليس فقط لأن + +517 +00:40:07,750 --> 00:40:12,530 +لدي 100 دولار، يعني أنني يجب أن أدفع 100 دولار في + +518 +00:40:12,530 --> 00:40:17,200 +هذه الانتجارةلا اذا لم تكن لديك 1 مليون دولار + +519 +00:40:17,200 --> 00:40:23,160 +فلديك 0 دولار. هل يمكنك أن تبدأ الشركة؟ نعم، لازم + +520 +00:40:23,160 --> 00:40:28,200 +تبدأ الشركة. أكتر الناس اللي بدأت شركتها كانت بدأت + +521 +00:40:28,200 --> 00:40:29,400 +بدأت بدأت بدأت بدأت بدأت بدأت بدأت بدأت بدأت بدأت + +522 +00:40:29,400 --> 00:40:29,420 +بدأت بدأت بدأت بدأت بدأت بدأت بدأت بدأت بدأت بدأت + +523 +00:40:29,420 --> 00:40:29,440 +بدأت بدأت بدأت بدأت بدأت بدأت بدأت بدأت بدأت بدأت + +524 +00:40:29,440 --> 00:40:29,620 +بدأت بدأت بدأت بدأت بدأت بدأت بدأت بدأت بدأت بدأت + +525 +00:40:29,620 --> 00:40:41,460 +بدأ + +526 +00:40:42,450 --> 00:40:48,730 +بقى relaxing is giving you opportunity to be + +527 +00:40:48,730 --> 00:40:54,610 +behind okay so let's stop in this point in the + +528 +00:40:54,610 --> 00:40:58,870 +second one how should the fam fund these + +529 +00:40:58,870 --> 00:41:04,210 +investments okay نجح ل end اللحظة هذه و كيف + +530 +00:41:04,210 --> 00:41:07,690 +المستوى اللي بعد ده كويس ولا صعب شهد اه؟ + +531 +00:41:20,190 --> 00:41:26,830 +طيب احنا .. طيب we stop in the second point okay + +532 +00:41:26,830 --> 00:41:34,250 +and in the next meeting we will talk about the why + +533 +00:41:34,250 --> 00:41:39,190 +study financeSo in the first one we talk about + +534 +00:41:39,190 --> 00:41:41,990 +what finance and then in the next meeting we will + +535 +00:41:41,990 --> 00:41:45,890 +talk why study finance and the .. we will ask + +536 +00:41:45,890 --> 00:41:48,750 +about different organizations forms So prepare + +537 +00:41:48,750 --> 00:41:51,410 +yourself in reading the first chapter because + +538 +00:41:51,410 --> 00:41:54,830 +maybe .. maybe the second two chapters .. second + +539 +00:41:54,830 --> 00:41:57,610 +two meetings we will finish this chapter Okay + +540 +00:41:57,610 --> 00:41:58,950 +thank you very much and take care + diff --git a/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/msVijzGt2kg_postprocess.srt b/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/msVijzGt2kg_postprocess.srt new file mode 100644 index 0000000000000000000000000000000000000000..149dc880dc6e79c088c3e005601a59852865172d --- /dev/null +++ b/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/msVijzGt2kg_postprocess.srt @@ -0,0 +1,1576 @@ +1 +00:00:19,690 --> 00:00:25,430 +بسم الله الرحمن الرحيم الفاكو + +2 +00:00:25,430 --> 00:00:30,790 +نحكي عن ال internal rate of return ال IRR and we + +3 +00:00:30,790 --> 00:00:36,710 +talk about the IRR and its present valueوقد ذكرنا + +4 +00:00:36,710 --> 00:00:42,870 +أن IRR لديه بعض المشاكل واحدة من هذه المشاكل أنه + +5 +00:00:42,870 --> 00:00:47,070 +إذا كان لدينا بعض الانتجارات الخاطئة، على سبيل + +6 +00:00:47,070 --> 00:00:50,230 +المثال إذا كنت تنظر إلى هذا المثال هنا، إذا كان + +7 +00:00:50,230 --> 00:00:57,270 +لدينا الانتجارات المالية على + +8 +00:00:57,270 --> 00:01:03,070 +سبيل المثال 10 ألف دولار، حسنا؟ ولدينا انتجارات + +9 +00:01:03,070 --> 00:01:09,970 +الانتجارات 3000 دولار 2000 دولار وانظر هنا اقل من + +10 +00:01:09,970 --> 00:01:19,070 +3000 دولار وهنا 4000 دولار او اذا 6000 دولار في + +11 +00:01:19,070 --> 00:01:31,610 +هذه الحالة اذا استخدمنا IRR سوف ننتهي مع 2 IRR هذا + +12 +00:01:31,610 --> 00:01:41,020 +المشكلةإذا تنظر إلى هذا المثال في هنا لدينا + +13 +00:01:41,020 --> 00:01:50,140 +في الـ 10% قيمة الـ net present value هي 0 ثم في + +14 +00:01:50,140 --> 00:01:56,260 +الـ 20% قيمة الـ net present value هي أيضًا 0 لذلك + +15 +00:01:56,260 --> 00:02:01,560 +هذا هو المشكلة للـ IRR المسألة كيف نستخدمها لتنصيب + +16 +00:02:01,560 --> 00:02:06,170 +هذا المشكلةباستخدام الـ Modified Internal Rate of + +17 +00:02:06,170 --> 00:02:12,030 +Return ماهي الهدف من خلال الـ AMIRAR اللي هو + +18 +00:02:12,030 --> 00:02:20,010 +Modified Internal Rate of Return هو أن نحاول إزالة + +19 +00:02:20,010 --> 00:02:24,670 +تأثير الـ Negative Side لذلك نحن نسأل نفسنا أين هو + +20 +00:02:24,670 --> 00:02:33,700 +الـ Cash Outflow في هنا، هذا هو Cash Outflowفنحن + +21 +00:02:33,700 --> 00:02:42,860 +نحاول أن نتخلص من هذا و نضيفه للاتجارات الأولى ثم + +22 +00:02:42,860 --> 00:02:49,720 +نتخلص من كيف نفعل هذا كيف + +23 +00:02:49,720 --> 00:02:55,400 +نفعل هذا هذا يأتي في السنة الثالثة أربعة ألف واحدة + +24 +00:02:55,400 --> 00:03:02,420 +تخلص من واحدة اضافة ككالـ K هنا هو قيمة المصادر + +25 +00:03:02,420 --> 00:03:10,980 +كما ذكرت قبلها ثم لدينا على سبيل المثال 3,1 + +26 +00:03:10,980 --> 00:03:17,060 +ونستخدم الـ K في 10% أعلى إلى 3 أعلى تخيل هذا + +27 +00:03:17,060 --> 00:03:23,940 +أرجوك نعم في المفارقة فقط لأريك كيف يعمل + +28 +00:03:29,000 --> 00:03:38,120 +2.2 ، ف2.2 هو اتفاق الخروج من المال ، لذلك هنا + +29 +00:03:38,120 --> 00:03:45,600 +نقوم الأن بإتفاق النتائج وانتظروا الآن كيف يبدو + +30 +00:03:45,600 --> 00:03:49,120 +أسلوب الهاتف ، حسنًا ، لذلك لدينا نصف ، لدينا واحد + +31 +00:03:49,120 --> 00:03:55,200 +، لدينا اثنين ، لدينا ثلاثة ولدينا أربعة ، اضافنا + +32 +00:03:55,200 --> 00:04:02,460 +10على 2.2 ، لذلك نحن لدينا 12.2 ، لذلك الاستثمار + +33 +00:04:02,460 --> 00:04:08,200 +الأول يصبح 12.2. الأن نحن لدينا 3 ألف ، نحن لدينا + +34 +00:04:08,200 --> 00:04:13,820 +2 ألف وماذا لدينا هنا؟ نحن لدينا 0 ، نعم أنت محق، + +35 +00:04:13,820 --> 00:04:20,900 +ونحن لدينا هنا 6. ثم نقوم بتخطيط IRR كمعروف، تجارب + +36 +00:04:20,900 --> 00:04:28,450 +وخطأ.هذه هي الفكرة عن IRR Modify Internal Rate of + +37 +00:04:28,450 --> 00:04:33,470 +Return هل + +38 +00:04:33,470 --> 00:04:42,990 +لديك أسئلة؟ هل + +39 +00:04:42,990 --> 00:04:46,990 +لديك أسئلة عن IRR؟ هل لديك أسئلة؟ + +40 +00:05:06,200 --> 00:05:10,360 +لذلك مدفع الـ Internal Rate of Return يتعامل مع + +41 +00:05:10,360 --> 00:05:15,440 +مشكلة عدد مرتبط IRR كما ذكرت هذا يتم فعله بإعادة + +42 +00:05:15,440 --> 00:05:22,440 +تحويل المال لكي يكون هناك تغيير واحد من إشارة + +43 +00:05:22,440 --> 00:05:26,740 +المال على الحياة، لذلك إذا كنت تشاهد هنا فقط لدينا + +44 +00:05:26,740 --> 00:05:31,510 +إشارات positiveبالـ Cash Cash Flow أو بـ Discount + +45 +00:05:31,510 --> 00:05:35,310 +Cash Flow و لدينا فقط إحدى الإشارات الخاطئة في + +46 +00:05:35,310 --> 00:05:40,710 +الانتجارات الأولى فهذه + +47 +00:05:40,710 --> 00:05:45,050 +هي الأولى أسابيع كما فعلناها هنا أول أسابيع هو + +48 +00:05:45,050 --> 00:05:50,830 +تخلص من الـ Cash Outflow و إضافة إلى الانتجارات + +49 +00:05:50,830 --> 00:05:55,210 +الأولى ثم أسابيع أخرى هي تخلص من IRR + +50 +00:05:57,190 --> 00:06:04,570 +إلا فإننا سننتهي بـ2 IRR في هذه الحالة سنحصل على + +51 +00:06:04,570 --> 00:06:09,090 +عدة IRR ولكن في هذه الحالة فإننا سنحصل على فقط 1 + +52 +00:06:09,090 --> 00:06:17,430 +IRR فهذه هي الطريقة التي قمنا بإزالة تأثير عدد كاش + +53 +00:06:17,430 --> 00:06:17,570 +مستخدم + +54 +00:06:23,210 --> 00:06:27,150 +Okay, you can take this example as well. So how + +55 +00:06:27,150 --> 00:06:32,070 +many cash out of flow we have here? We have the + +56 +00:06:32,070 --> 00:06:36,030 +initial investment and we have the negative cash + +57 +00:06:36,030 --> 00:06:39,870 +flow. So what we can do? Yeah, we discounted this. + +58 +00:06:40,030 --> 00:06:44,690 +We discounted this by 12%. Okay, let's do it + +59 +00:06:44,690 --> 00:06:45,310 +together here. + +60 +00:06:52,560 --> 00:07:01,900 +بعد ذلك قبلنا هذا 310200 310200 + +61 +00:07:01,900 --> 00:07:11,780 +÷ 0.1 plus K هو 12%² فماذا + +62 +00:07:11,780 --> 00:07:12,740 +هو النتيجة؟ + +63 +00:07:25,210 --> 00:07:28,030 +Two hundred and forty seven thousand two hundred + +64 +00:07:28,030 --> 00:07:36,350 +and thirty seven forty seven two hundred and + +65 +00:07:36,350 --> 00:07:44,090 +ninety okay so what is the streamline looks like + +66 +00:07:44,090 --> 00:07:47,730 +the new streamline looks like so we have here zero + +67 +00:07:47,730 --> 00:07:52,330 +we have one and we have two + +68 +00:07:54,960 --> 00:08:02,900 +ففي 2 نحن لدينا 0 في 1 نحن لدينا 40 ألف او 540 ألف + +69 +00:08:02,900 --> 00:08:15,320 +و5 ألف وانتشار الاستثمار هو 2 3 5 ألف و 2 4 7 2 90 + +70 +00:08:15,320 --> 00:08:21,600 +فما هو الأن 482 + +71 +00:08:24,770 --> 00:08:31,550 +290 وnegative و الأن نستخدم + +72 +00:08:31,550 --> 00:08:35,350 +IRR نستخدم IRR نستخدم IRR نستخدم IRR نستخدم IRR + +73 +00:08:35,350 --> 00:08:37,030 +نستخدم IRR نستخدم IRR نستخدم IRR نستخدم IRR نستخدم + +74 +00:08:37,030 --> 00:08:39,210 +IRR نستخدم IRR نستخدم IRR نستخدم IRR نستخدم IRR + +75 +00:08:39,210 --> 00:08:40,130 +نستخدم IRR نستخدم IRR نستخدم IRR نستخدم IRR نستخدم + +76 +00:08:40,130 --> 00:08:40,230 +IRR نستخدم IRR نستخدم IRR نستخدم IRR نستخدم IRR + +77 +00:08:40,230 --> 00:08:41,770 +نستخدم IRR نستخدم IRR نستخدم IRR نستخدم IRR نستخدم + +78 +00:08:41,770 --> 00:08:41,870 +IRR نستخدم IRR نستخدم IRR نستخدم IRR نستخدم IRR + +79 +00:08:41,870 --> 00:08:43,970 +نستخدم IRR نستخدم IRR نستخدم IRR نستخدم IRR + +80 +00:08:47,090 --> 00:08:55,890 +انت ترى؟ نعم هذا 482.90$ و 290$ و لدينا هذا و 0$ + +81 +00:08:55,890 --> 00:08:59,930 +بالنسبة لتجاربك يمكنني أسألك كيف نستخدمها لتنصيب + +82 +00:08:59,930 --> 00:09:06,510 +هذا المشكلة أعني أعطيك الـ Streamline و أنا أطلب + +83 +00:09:06,510 --> 00:09:10,690 +منك أن تقوم بإعادة Streamline باستخدام قيمة عادية + +84 +00:09:10,690 --> 00:09:16,900 +تغييرها للداخل فقط فعلها بهذه الطريقةكما ذكرت في + +85 +00:09:16,900 --> 00:09:26,560 +هذا المثال حسنا؟ + +86 +00:09:26,560 --> 00:09:40,680 +حسنا، + +87 +00:09:40,680 --> 00:09:41,300 +و الأن مرات الدفع + +88 +00:09:50,470 --> 00:09:57,170 +الان ماذا يعني بيباك الوقت؟ بيباك + +89 +00:09:57,170 --> 00:10:05,110 +الوقت يعني كم وقت يستغرق لكي تدفع أو دعنا نقول لكي + +90 +00:10:05,110 --> 00:10:09,730 +تدفع لدفع مستخدمنا الأول؟ على سبيل المثال، إذا + +91 +00:10:09,730 --> 00:10:17,880 +مستخدمك الأول هو 10 ألف دولار، فكيف ستبعد 10 ألف + +92 +00:10:17,880 --> 00:10:22,320 +دولار كم وقت استخدامه؟ في هذه الحالة نحن نسأل عن + +93 +00:10:22,320 --> 00:10:28,340 +عدد السنوات أو عن الوقتات وهذه هي السؤال الأولى + +94 +00:10:28,340 --> 00:10:34,000 +عندما تجيب على ما إذا اقبلت أو اقفلت انفصارك كم + +95 +00:10:34,000 --> 00:10:39,390 +وقت استخدامه؟Okay it takes two years, three years + +96 +00:10:39,390 --> 00:10:43,490 +or whatever So the decision in this case depends + +97 +00:10:43,490 --> 00:10:46,830 +on that the project with the shorter period is + +98 +00:10:46,830 --> 00:10:50,550 +more acceptable than the project with the longer + +99 +00:10:50,550 --> 00:10:56,030 +period So if I'm trade-off between two projects + +100 +00:10:56,030 --> 00:11:03,270 +project A and project Bوفترة التدفع من project A + +101 +00:11:03,270 --> 00:11:08,370 +هي ثلاث سنوات وهذه خمس سنوات لذلك بالتأكيد سأقبل + +102 +00:11:08,370 --> 00:11:17,410 +project A حسنا مرة أخرى هناك مشكلة في هذا الموضوع + +103 +00:11:17,410 --> 00:11:24,390 +هل يمكنك تفكير ماهي المشكلة؟ نعم الأول هو عمل وقت + +104 +00:11:24,390 --> 00:11:26,430 +المال دعونا نفكر في هذه الحالة + +105 +00:11:33,240 --> 00:11:42,440 +إذا كان لدينا هذه الانفصالات، فهذه هي الانفصالات + +106 +00:11:42,440 --> 00:11:52,740 +المالية وهذه + +107 +00:11:52,740 --> 00:11:56,060 +هي الانفصالات المالية، فالانفصال الأول هو 10 ألف + +108 +00:11:56,060 --> 00:12:01,920 +دولارخلاص، هذه هي الانتجارات الأولى في السنة واحدة + +109 +00:12:01,920 --> 00:12:07,660 +نحن نحصل على ثلاثة ألف في السنة ثلاثة ألف ثم السنة + +110 +00:12:07,660 --> 00:12:15,560 +ثلاثة أربع ألف ودعنا نقول 2500 و4000 هذا هو مجموعة + +111 +00:12:15,560 --> 00:12:21,780 +المال السابق السؤال الأول المستخدمين يسألون أنفسهم + +112 +00:12:21,780 --> 00:12:29,860 +كم وقت تستغرق لإعادة المالOkay this is the initial + +113 +00:12:29,860 --> 00:12:35,560 +question that they asking So how they do this it + +114 +00:12:35,560 --> 00:12:41,040 +is very simple let's take the first one is 3000 + +115 +00:12:41,040 --> 00:12:54,820 +how much I need I need 7000 yes if we add up so we + +116 +00:12:54,820 --> 00:13:03,830 +need 5000إذا قمنا بإضافة أربعة آلاف فهو ثلاثة او + +117 +00:13:03,830 --> 00:13:07,190 +خمس او خمس او خمس او خمس او خمس او خمس او خمس او + +118 +00:13:07,190 --> 00:13:08,150 +خمس او خمس او خمس او خمس او خمس او خمس او خمس او + +119 +00:13:08,150 --> 00:13:09,050 +خمس او خمس او خمس او خمس او خمس او خمس او خمس او + +120 +00:13:09,050 --> 00:13:09,150 +خمس او خمس او خمس او خمس او خمس او خمس او خمس او + +121 +00:13:09,150 --> 00:13:11,490 +خمس او خمس او خمس او خمس او خمس او خمس او خمس او + +122 +00:13:11,490 --> 00:13:21,770 +خمس او خمس او خمس او خمس او + +123 +00:13:21,770 --> 00:13:25,350 +خمس + +124 +00:13:26,720 --> 00:13:31,080 +Spend or spend in the year four it means one + +125 +00:13:31,080 --> 00:13:34,040 +thousand divided by two thousand five hundred + +126 +00:13:34,040 --> 00:13:38,840 +Okay, so it's point four what it means it means it + +127 +00:13:38,840 --> 00:13:46,000 +takes three Years and point four of the year So if + +128 +00:13:46,000 --> 00:13:50,820 +you convert it to the month just time point four + +129 +00:13:50,820 --> 00:13:51,900 +times twelve + +130 +00:13:56,410 --> 00:14:03,790 +.4×12 4.8 تقريبًا خمس أشهر فهو يأخذ حوالي ثلاث سنة + +131 +00:14:03,790 --> 00:14:11,050 +وخمس أشهر إذا كنت ترغب في تسجيله على مدى الأيام + +132 +00:14:11,050 --> 00:14:15,910 +فقط مرة.4×365 + +133 +00:14:19,210 --> 00:14:24,350 +لذلك يستغرق ثلاث سنوات و 146 + +134 +00:14:24,350 --> 00:14:30,230 +يوم. لذلك هنا سنوات و هنا يوم. رقم الأيام. إذا كنت + +135 +00:14:30,230 --> 00:14:33,790 +ترغب في التخلص من السنة مرة مرة مرة مرة مرة مرة + +136 +00:14:33,790 --> 00:14:33,850 +مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة + +137 +00:14:33,850 --> 00:14:35,430 +مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة + +138 +00:14:35,430 --> 00:14:36,330 +مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة + +139 +00:14:36,330 --> 00:14:37,510 +مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة + +140 +00:14:37,510 --> 00:14:37,770 +مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة مرة + +141 +00:14:37,770 --> 00:14:41,410 +مرة مرة مرة مرة + +142 +00:14:41,410 --> 00:14:42,810 +م + +143 +00:14:45,460 --> 00:14:53,480 +على فترة وقت المال اللي هو هذا هو مرتبط + +144 +00:14:53,480 --> 00:14:59,100 +بقيمة وقت المال أو مرتبط بوقت كم يتطلب لإعادة + +145 +00:14:59,100 --> 00:15:04,000 +المال أو لإعادة المال ولكن الـ net present value + +146 +00:15:04,000 --> 00:15:11,040 +أو ال IRR يستخدم ميثوطات مختلفة لإيجاب ممكنة + +147 +00:15:11,040 --> 00:15:18,220 +المشروع مرة أخرىكما ذكرت في الـ IRR وNet Present + +148 +00:15:18,220 --> 00:15:26,400 +Value يعني أن كلهم لديهم بعض المقالات المقالات من + +149 +00:15:26,400 --> 00:15:38,760 +هذا كما ذكرت أن عدد المساعدة لا يهتم بمهمة عدد وقت + +150 +00:15:38,760 --> 00:15:43,560 +المال على سبيل المثال إذا كنت تنظر إلى هذا المثال + +151 +00:15:43,560 --> 00:15:50,670 +هنالسنا نهتم في وقت ما يأتي المال من المدفع. نهتم + +152 +00:15:50,670 --> 00:15:56,570 +فقط في وقت ما نستطيع أن نعيد المال لنا. لذلك + +153 +00:15:56,570 --> 00:16:01,710 +نتعامل 3000$ في السنة الأولى ب2000$ في السنة + +154 +00:16:01,710 --> 00:16:09,250 +الثانوية وهذا غير صحيح لأنقيمة 4 ألف دولار تأتي في + +155 +00:16:09,250 --> 00:16:14,610 +الثالث عام ليس مثل قيمة 4 ألف دولار تأتي في السنة + +156 +00:16:14,610 --> 00:16:21,770 +الأولى، حسنًا؟ لهذا السبب مهمة تغيير عدالة التدفع + +157 +00:16:21,770 --> 00:16:26,410 +لتفكير قيمة الوقت من المال، هذا هو المشكلة الأولى + +158 +00:16:26,410 --> 00:16:34,510 +المشكلة الثانوية هي أننا نغيّر تدفع المال خارج + +159 +00:16:34,510 --> 00:16:42,040 +عدالة التدفعننظر إلى هنا على سبيل المثال في هذا + +160 +00:16:42,040 --> 00:16:52,300 +المثال هنا ننسى 4000$ و 2500$ و هنا ننسى 2500$ + +161 +00:16:56,210 --> 00:17:00,310 +تعتبر ألف واحدة ونغلق ألف وخمس ألف وخمس ألف وخمس + +162 +00:17:00,310 --> 00:17:02,430 +ألف وخمس ألف وخمس ألف وخمس ألف وخمس ألف وخمس ألف + +163 +00:17:02,430 --> 00:17:03,770 +وخمس ألف وخمس ألف وخمس ألف وخمس ألف وخمس ألف وخمس + +164 +00:17:03,770 --> 00:17:04,770 +ألف وخمس ألف وخمس ألف وخمس ألف وخمس ألف وخمس ألف + +165 +00:17:04,770 --> 00:17:05,930 +وخمس ألف وخمس ألف وخمس ألف وخمس ألف وخمس ألف وخمس + +166 +00:17:05,930 --> 00:17:07,390 +ألف وخمس ألف وخمس ألف وخمس ألف وخمس ألف وخمس ألف + +167 +00:17:07,390 --> 00:17:25,050 +وخمس ألف وخمس ألف وخمس ألف وخمس ألف وخمس + +168 +00:17:30,750 --> 00:17:36,090 +هذا هو المشكلة. المشكلة الثانية هي عندما نحصل على + +169 +00:17:36,090 --> 00:17:36,970 +مستخدمات مجموعة و مجموعة و مجموعة مجموعة مجموعة + +170 +00:17:36,970 --> 00:17:37,730 +مجموعة مجموعة مجموعة مجموعة مجموعة مجموعة مجموعة + +171 +00:17:37,730 --> 00:17:38,690 +مجموعة مجموعة مجموعة مجموعة مجموعة مجموعة مجموعة + +172 +00:17:38,690 --> 00:17:40,810 +مجموعة مجموعة مجموعة مجموعة مجموعة مجموعة مجموعة + +173 +00:17:40,810 --> 00:17:41,170 +مجموعة مجموعة مجموعة مجموعة مجموعة مجموعة مجموعة + +174 +00:17:41,170 --> 00:17:48,610 +مجموعة مجموعة مجموعة مجموعة + +175 +00:17:48,610 --> 00:17:56,670 +مجموعة مجموع + +176 +00:17:57,920 --> 00:18:04,580 +نعيد مالنا في ثلاث سنة، هذا حسنًا، هذا مقبول، لكن + +177 +00:18:04,580 --> 00:18:09,060 +في هذا المثال نعيد مالنا في ثلاث وخمس أشهر، لذلك + +178 +00:18:09,060 --> 00:18:15,260 +ليس مقبولًا.السؤال هو من قام بالمعاملات لمرحلة + +179 +00:18:15,260 --> 00:18:22,100 +الوقت؟ نعم، لذلك المشكلة هي أن كل مشروع له مميزته + +180 +00:18:23,780 --> 00:18:30,060 +أفضالها أو لديها مصادر مختلفة لذلك المهم في + +181 +00:18:30,060 --> 00:18:37,460 +الانتقال لا يوجد اتفاق بين الاناليست المالي ماهي + +182 +00:18:37,460 --> 00:18:42,160 +السنة المقبولة في الانتقال نحن لا نستطيع أن نقول + +183 +00:18:42,160 --> 00:18:46,880 +حسنًا ثلاث سنة حسنًا خمس سنة حسنًا و لا نستطيع أن + +184 +00:18:46,880 --> 00:18:50,840 +نحكم في هذا هذا هو المشكلة لكننا نستطيع أن نحكم في + +185 +00:18:50,840 --> 00:19:00,530 +ال 10%الـ IRR هو أفضل من 8% من الـ IRR هذا بسيط + +186 +00:19:00,530 --> 00:19:10,510 +جدا ولكن بمعنى فترة الدفع لا يوجد نقطة مفهومة فهذه + +187 +00:19:10,510 --> 00:19:11,450 +هي المشكلة + +188 +00:19:22,100 --> 00:19:26,580 +بعض الوقت من الوقت من الوقت من الوقت من الوقت من + +189 +00:19:26,580 --> 00:19:30,460 +الوقت + +190 +00:19:30,460 --> 00:19:36,460 +من الوقت من الوقت من الوقت من الوقت من الوقت من + +191 +00:19:36,460 --> 00:19:41,660 +الوقت من الوقت + +192 +00:19:41,660 --> 00:19:43,700 +من الوقت + +193 +00:19:45,030 --> 00:19:51,230 +فقمنا بالتخلص من حجم المال ثم نفعلها مرة أخرى + +194 +00:19:51,230 --> 00:20:08,990 +دعونا نرى مثلنا حسنا اذا اعتبر ال K يقل 5% لذلك + +195 +00:20:08,990 --> 00:20:12,270 +الان نريد ان نعود و نتخلص من السنوات التالية + +196 +00:20:16,940 --> 00:20:29,440 +مع 1 اضافة K هي 5% أعلى 1 ثم 2000 1 اضافة K أعلى 2 + +197 +00:20:29,440 --> 00:20:48,830 +4000 1.05 أعلى 3 ثم 2500 1.05 أعلىماذا يوجد هنا 4 + +198 +00:20:48,830 --> 00:20:57,790 +ألف 4 ألف 4 ألف 4 ألف 1.05⁵ + +199 +00:20:57,790 --> 00:21:03,690 +5 فماذا + +200 +00:21:03,690 --> 00:21:11,490 +هي النتائج هنا ماذا + +201 +00:21:11,490 --> 00:21:17,800 +تعتقد؟الوقت المدفع يأخذ وقت أطول أو أقصر؟ هذه + +202 +00:21:17,800 --> 00:21:22,020 +السؤال للناس + +203 +00:21:22,020 --> 00:21:28,760 +الذين يأتوا في اللحظة ماذا تفكر؟ في هنا الوقت + +204 +00:21:28,760 --> 00:21:35,480 +المدفع في هذه الحالة يأخذ وقت أطول أو أقصر؟ لا + +205 +00:21:35,480 --> 00:21:36,540 +تحتاج حتى أن تفكر + +206 +00:21:41,280 --> 00:21:45,000 +مقارنة مع هذه النتائج هل يستغرق وقت أطول أو أقل + +207 +00:21:45,000 --> 00:21:54,040 +وقت أطول نعم بالتأكيد يستغرق وقت أطول لأنك قد قفلت + +208 +00:21:54,040 --> 00:21:57,700 +المال لذا عليك المزيد من الوقت لكي تقوم بإعادة + +209 +00:21:57,700 --> 00:22:05,010 +قيمة القفل لذلك بالتأكيد يستغرق وقت أطولOkay so + +210 +00:22:05,010 --> 00:22:08,250 +careful in the multiple choice questions sometimes + +211 +00:22:08,250 --> 00:22:11,270 +in your multiple choice questions you don't even + +212 +00:22:11,270 --> 00:22:17,730 +need to use the calculator you don't even just if + +213 +00:22:17,730 --> 00:22:20,450 +for instance if we calculate the the payback + +214 +00:22:20,450 --> 00:22:26,330 +period is three years then we use the modified + +215 +00:22:26,330 --> 00:22:30,980 +payback periods what is the resultsاستخدم الاختيار + +216 +00:22:30,980 --> 00:22:38,140 +المرتبط 1,2,3,4 نتيجة يقل ل3 سنة او اكتر من 3 سنة + +217 +00:22:38,140 --> 00:22:40,780 +او اكتر من 3 سنة او اكتر من 3 سنة او اكتر من 3 سنة + +218 +00:22:40,780 --> 00:22:44,600 +او اكتر من 3 سنة او + +219 +00:22:44,600 --> 00:22:44,920 +اكتر من 3 سنة او اكتر من 3 سنة او اكتر من 3 سنة او + +220 +00:22:44,920 --> 00:22:45,320 +اكتر من 3 سنة او اكتر من 3 سنة او اكتر من 3 سنة او + +221 +00:22:45,320 --> 00:22:50,180 +اكتر من 3 سنة او اكتر من 3 سنة او اكتر من 3 سنة او + +222 +00:22:50,180 --> 00:22:51,180 +اكتر + +223 +00:23:01,620 --> 00:23:08,980 +اوكي فقط اصطحب رأسك اوكي اذا ماهو النتائج؟ نعم + +224 +00:23:08,980 --> 00:23:17,140 +الأولة؟ اوكي + +225 +00:23:17,140 --> 00:23:28,040 +اغنوه ال .. اوكي اغنوه ال .. اوكي اغنوه ال ..four + +226 +00:23:28,040 --> 00:23:32,440 +hundred fifty five fifty five two thousand fifty + +227 +00:23:32,440 --> 00:23:38,720 +six fifty six like this three thousand one hundred + +228 +00:23:38,720 --> 00:23:44,340 +thirty four thirty three four thirty four okay now + +229 +00:23:44,340 --> 00:23:47,460 +what + +230 +00:23:47,460 --> 00:23:53,130 +we have you can use different methodologiesSo just + +231 +00:23:53,130 --> 00:23:57,610 +add up 2800 to 1000, add up with this, here we + +232 +00:23:57,610 --> 00:24:06,230 +have 2857, add this 1800 to .. لا لا لا do it in + +233 +00:24:06,230 --> 00:24:10,730 +different way, just add this to this one + +234 +00:24:14,250 --> 00:24:20,130 +أنا أحاول أن أستخدم ميثوبة مختلفة 4671 + +235 +00:24:20,130 --> 00:24:21,950 +ميثوبة مختلفة ميثوبة مختلفة ميثوبة مختلفة ميثوبة + +236 +00:24:21,950 --> 00:24:22,610 +مختلفة ميثوبة مختلفة ميثوبة مختلفة ميثوبة مختلفة + +237 +00:24:22,610 --> 00:24:22,810 +ميثوبة مختلفة ميثوبة مختلفة ميثوبة مختلفة ميثوبة + +238 +00:24:22,810 --> 00:24:24,710 +مختلفة ميثوبة مختلفة ميثوبة مختلفة ميثوبة مختلفة + +239 +00:24:24,710 --> 00:24:26,350 +ميثوبة مختلفة ميثوبة مختلفة ميثوبة مختلفة مختلفة + +240 +00:24:26,350 --> 00:24:27,190 +ميثوبة مختلفة مختلفة مختلفة مختلفة مختلفة مختلفة + +241 +00:24:27,190 --> 00:24:30,950 +مختلفة + +242 +00:24:30,950 --> 00:24:42,070 +مختلفة مختلفة مختلف + +243 +00:24:42,590 --> 00:24:50,990 +الآخر هو ثلاث سنوات و ربما 11 أشهر لأننا على + +244 +00:24:50,990 --> 00:25:02,730 +الجانب كيف نضيف هذا فقط اختلط 182 اختلط ب 2056 + +245 +00:25:02,730 --> 00:25:08,910 +182 + +246 +00:25:08,910 --> 00:25:18,700 +4%0.08 ، لذلك 0.08 مرات ب .. دعنا نرى 12 أشهر + +247 +00:25:18,700 --> 00:25:21,760 +لأننا + +248 +00:25:21,760 --> 00:25:26,500 +لدينا ثلاث سنوات فقط + +249 +00:25:26,500 --> 00:25:30,520 +فقط أشهر فقط فقط فقط فقط فقط فقط فقط فقط فقط فقط + +250 +00:25:30,520 --> 00:25:30,560 +فقط فقط فقط فقط فقط فقط فقط فقط فقط فقط فقط فقط + +251 +00:25:30,560 --> 00:25:30,700 +فقط فقط فقط فقط فقط فقط فقط فقط فقط فقط فقط فقط + +252 +00:25:30,700 --> 00:25:32,440 +فقط فقط فقط فقط فقط فقط فقط فقط فقط فقط فقط فقط + +253 +00:25:32,440 --> 00:25:40,160 +فقط فقط فقط فقط فقط + +254 +00:25:40,160 --> 00:25:44,500 +فقطبعد أن قمنا بالتخلص من المال يستغرق ثلاث سنوات + +255 +00:25:44,500 --> 00:26:01,120 +و 11 أشهر لذلك يستغرق وقت طويل حسنا؟ + +256 +00:26:01,120 --> 00:26:06,220 +هل لدي + +257 +00:26:06,220 --> 00:26:11,990 +أسئلة؟ أنا أستخدم اتصالين مختلفةانت فقط تحاول + +258 +00:26:11,990 --> 00:26:19,350 +تفكير في طريقات مختلفة حسنا؟ حسنا اخذ صورتك + +259 +00:26:53,640 --> 00:26:59,460 +Okay I think + +260 +00:26:59,460 --> 00:27:02,860 +I shouldn't answer this question just keep focus + +261 +00:27:02,860 --> 00:27:05,500 +on it this is more important than what you asking + +262 +00:27:12,740 --> 00:27:18,880 +what i did in thisهذه هي قيمة المال هي 2800 دولار + +263 +00:27:18,880 --> 00:27:25,920 +والثانوية هي المجموعة 1800 مليون مليون مليون مليون + +264 +00:27:25,920 --> 00:27:26,480 +مليون مليون مليون مليون مليون مليون مليون مليون + +265 +00:27:26,480 --> 00:27:26,860 +مليون مليون مليون مليون مليون مليون مليون مليون + +266 +00:27:26,860 --> 00:27:29,960 +مليون مليون مليون مليون + +267 +00:27:29,960 --> 00:27:30,200 +مليون مليون مليون مليون مليون مليون مليون مليون + +268 +00:27:30,200 --> 00:27:32,540 +مليون مليون مليون مليون مليون مليون مليون مليون + +269 +00:27:32,540 --> 00:27:32,740 +مليون مليون مليون مليون مليون مليون مليون مليون + +270 +00:27:32,740 --> 00:27:32,760 +مليون مليون مليون مليون مليون مليون مليون مليون + +271 +00:27:32,760 --> 00:27:41,100 +مليون مليون + +272 +00:27:45,660 --> 00:27:51,740 +و 182 مقارنة 182 مع 2000 هي تأتي في نهاية العام + +273 +00:27:51,740 --> 00:27:57,740 +انا + +274 +00:27:57,740 --> 00:28:03,580 +استخدمت اتصالين مختلفة لماذا؟ لأن في بعض الكتب + +275 +00:28:03,580 --> 00:28:07,320 +يوجد هذه التفكيرات وفي كتب أخرى يوجد هذه التفكيرات + +276 +00:28:07,320 --> 00:28:12,800 +لذلك انت مخلص لتفعل ما تريده في نهاية اليوم تحصل + +277 +00:28:12,800 --> 00:28:20,820 +على نفس التجاربطيب فقط توقف هنا تفعل الاختصار، هذا + +278 +00:28:20,820 --> 00:28:31,220 +يبدأ بال .. ثم اضيف هو مثل هذا ثم + +279 +00:28:31,220 --> 00:28:34,460 +لديك 10 ألف .. توقف، حسنًا ، لذلك 10 ألف ، لقد + +280 +00:28:34,460 --> 00:28:42,420 +استخدمت .. لذلك 10 ألف ، لديك فقط اضافة 182 حسنًا + +281 +00:28:42,420 --> 00:28:43,760 +، لذلك اختلط ب .. + +282 +00:28:46,820 --> 00:28:52,840 +انت تستخدم كل هذا الـ2000 من المنطقة المالية انت + +283 +00:28:52,840 --> 00:29:01,180 +تستخدم كل الـ2000 و2056 وانت لديك المزيد اضافة 182 + +284 +00:29:01,180 --> 00:29:04,620 +حسنا؟ + +285 +00:29:04,620 --> 00:29:12,120 +لذا حاول ان تستخدم مصممة هذه المقاومة حسنا؟ + +286 +00:29:27,160 --> 00:29:32,960 +ماذا هو الجمال أو الاحتياطات للوقت المدفع أو الوقت + +287 +00:29:32,960 --> 00:29:33,400 +المدفع + +288 +00:29:36,500 --> 00:29:42,660 +مهمة الـ Modified و Payback period كلاها أسهل ان + +289 +00:29:42,660 --> 00:29:48,660 +تفهمها و تجهزها ايضا لا يوجد حتى مهارات مثالية + +290 +00:29:48,660 --> 00:29:54,700 +لتخطيط ال period payback و payback modified okay + +291 +00:29:54,700 --> 00:30:00,920 +هذه هي الأشياء و + +292 +00:30:00,920 --> 00:30:05,130 +مرة أخرىإذا كانت المدفعات مفيدة من المدافعات + +293 +00:30:05,130 --> 00:30:07,590 +والمدفعات المدفعات المدفعات المدفعات المدفعات + +294 +00:30:07,590 --> 00:30:10,890 +المدفعات المدفعات المدفعات مدفعات مدفعات مدفعات + +295 +00:30:10,890 --> 00:30:17,370 +مدفعات مدفعات مدفعات مدفعات مدفعات + +296 +00:30:22,630 --> 00:30:29,590 +لتأكيد أنهم يحفظوا مالهم في الأسابيع الأولى في + +297 +00:30:29,590 --> 00:30:36,990 +حياة المشروع لذلك يتفكير رغبات المشروع لذلك يمكن + +298 +00:30:36,990 --> 00:30:41,150 +أن يكون بيباك كإشارة عظيمة لرغبات رغبات بيباك في + +299 +00:30:41,150 --> 00:30:45,930 +أول عام المال أعني أسابيع الأولى أو الـ 30 مليون + +300 +00:30:45,930 --> 00:30:50,330 +دولار عامة عامة عامة عامة عامة عامة عامة عامة عامة + +301 +00:30:51,740 --> 00:30:54,840 +لأن إذا كانت المالية تأتي في اللحظة، فهذا يعني + +302 +00:30:54,840 --> 00:30:59,300 +أننا لدينا خطر لذلك نريد أن نحافظ على ال .. حسنًا، + +303 +00:30:59,300 --> 00:31:01,800 +كما تعلمون في الطريقة الإيجابية، قالوا نتلاهم على + +304 +00:31:01,800 --> 00:31:06,640 +الفلوس، هل تعرفين ماذا يعني؟ أظهروا المال، حسنًا، + +305 +00:31:06,640 --> 00:31:10,200 +المال يأتي بسرعة، هو حسنًا، إذا كانت تأتي في + +306 +00:31:10,200 --> 00:31:19,360 +اللحظة، فهو يعني أننا قد نكون مضطرين للخطر حسنًا، + +307 +00:31:19,360 --> 00:31:20,020 +هذا حسنًا + +308 +00:31:23,380 --> 00:31:26,920 +مدفع مدفع مدفع مدفع مدفع مدفع مدفع مدفع مدفع مدفع + +309 +00:31:26,920 --> 00:31:28,900 +مدفع مدفع مدفع مدفع مدفع مدفع مدفع مدفع مدفع مدفع + +310 +00:31:28,900 --> 00:31:29,780 +مدفع مدفع مدفع مدفع مدفع مدفع مدفع مدفع مدفع مدفع + +311 +00:31:29,780 --> 00:31:34,220 +مدفع مدفع مدفع مدفع مدفع مدفع مدفع مدفع مدفع مدفع + +312 +00:31:34,220 --> 00:31:37,360 +مدفع مدفع مدفع مدفع مدفع مدفع مدفع مدفع مدفع مدفع + +313 +00:31:37,360 --> 00:31:47,620 +مدفع مدفع مدفع مدفع مدفع مدفع + +314 +00:31:52,800 --> 00:31:56,140 +التأكيد لتحفة المال الخاص بك في السنوات الأولى هي + +315 +00:31:56,140 --> 00:32:01,020 +أفضل من السنوات الأخيرة بالنسبة إذا كنت تقوم + +316 +00:32:01,020 --> 00:32:05,640 +بإطلاق أشياء جديدة لأشركتك وشركات أخرى تستخدمها + +317 +00:32:05,640 --> 00:32:12,040 +ويمكنهم إطلاق كتابة من أشركتك لتأكد من تحفة المال + +318 +00:32:12,040 --> 00:32:14,160 +الخاص بك + +319 +00:32:15,200 --> 00:32:19,320 +الوقت التدفع يكون مفيد عندما يتم تدفع المال + +320 +00:32:19,320 --> 00:32:23,060 +والمديرين يريدون أن يعرفون كم من الوقت قبل أن يتم + +321 +00:32:23,060 --> 00:32:29,920 +تدفع المال للمديرين التدفعيين لأنهم لديهم سلسلة + +322 +00:32:29,920 --> 00:32:34,380 +تدفع، لذلك يفكرون حسنًا عند ما يمكنني أن أعيد + +323 +00:32:34,380 --> 00:32:39,080 +المال، ثم نبدأ مشروع جديد وتدفع جديد وما إلى ذلك + +324 +00:32:45,530 --> 00:32:50,270 +هذه المقارنة تظهر مقارنة + +325 +00:32:50,270 --> 00:32:54,830 +ما بين قيمة متوفرة IR مقارنة مقارنة مقارنة مقارنة + +326 +00:32:54,830 --> 00:32:55,070 +مقارنة مقارنة مقارنة مقارنة مقارنة مقارنة مقارنة + +327 +00:32:55,070 --> 00:32:56,850 +مقارنة مقارنة مقارنة مقارنة مقارنة مقارنة مقارنة + +328 +00:32:56,850 --> 00:32:57,870 +مقارنة مقارنة مقارنة مقارنة مقارنة مقارنة مقارنة + +329 +00:32:57,870 --> 00:33:10,450 +مقارن + +330 +00:33:11,380 --> 00:33:13,300 +بالتالي، باعتبار المحافظة والاستثمار الأخير في + +331 +00:33:13,300 --> 00:33:20,360 +المحافظة والاستثمار في المحافظة + +332 +00:33:20,360 --> 00:33:21,060 +والاستثمار في المحافظة والاستثمار في المحافظة + +333 +00:33:21,060 --> 00:33:25,100 +والاستثمار في المحافظة والاستثمار في المحافظة + +334 +00:33:25,100 --> 00:33:28,480 +والاستثمار في المحافظة والاستثمار في المحافظة + +335 +00:33:28,480 --> 00:33:28,940 +والاستثمار في المحافظة والاستثمار في المحافظة + +336 +00:33:28,940 --> 00:33:28,980 +والاستثمار في المحافظة والاستثمار في المحافظة + +337 +00:33:28,980 --> 00:33:33,780 +والاستثمار في المحافظة والاستثمار في المحافظة + +338 +00:33:33,780 --> 00:33:39,080 +والاستثمار في المحافظة وال + +339 +00:33:43,210 --> 00:33:46,170 +كما نرى، النتائج تظهر أن طريقة Net Present Value + +340 +00:33:46,170 --> 00:33:49,670 +وIRR هي أكتر مشهورة، وكذلك في الكثير من الشركات + +341 +00:33:49,670 --> 00:33:53,770 +التي تستخدم طريقة Payback Period إذا كنت تنظر إلى + +342 +00:33:53,770 --> 00:33:58,250 +هذا التاريخ، ما تشاهده هو عدد الدفع الداخلي + +343 +00:33:58,250 --> 00:34:04,390 +والنتائج Net Present Value هي أكتر عادة تستخدمه + +344 +00:34:04,390 --> 00:34:09,610 +الرئيس الدولي أو الرئيسات الدوليةوانتجة الاستثمار + +345 +00:34:09,610 --> 00:34:15,050 +هي الأقل التي تستخدمها الرئيس الأمريكي والرئيس + +346 +00:34:15,050 --> 00:34:20,590 +الانتجة، حسنا؟ لذلك، على الرغم من ذلك، الوقت + +347 +00:34:20,590 --> 00:34:25,590 +التجاربي لازم يكون مهم، لكن ليس في نفس ال .. أو + +348 +00:34:25,590 --> 00:34:28,570 +ليس مشابه إلى IRR وقيمة الانتجة الأمريكية، إذا + +349 +00:34:28,570 --> 00:34:34,790 +رأيت هنا تقريبًا لدينا 80%من الرئيسين باستخدام + +350 +00:34:34,790 --> 00:34:40,710 +قيمة IRR وNet Present وقبل 60% باستخدام فترة + +351 +00:34:40,710 --> 00:34:46,130 +التدفع والتي تسجل تقريبًا لـ 30% من مجموعة + +352 +00:34:46,130 --> 00:34:50,250 +profitability index فهذا + +353 +00:34:50,250 --> 00:34:57,790 +يشد أضواء أكتر على مهمة قيمة Net Present وIRR + +354 +00:35:00,410 --> 00:35:06,090 +Okay any question of this only important of its + +355 +00:35:06,090 --> 00:35:15,550 +present value and IRR okay key terms just to say + +356 +00:35:15,550 --> 00:35:20,310 +goodbye to the this chapter okay oh don't say + +357 +00:35:20,310 --> 00:35:22,510 +goodbye please sorry + +358 +00:35:24,380 --> 00:35:28,660 +أنا لا أعرف، في الدراسة، حسنًا، فإن أقول وداعا بـ + +359 +00:35:28,660 --> 00:35:32,200 +Capital Rationing Capital Rationing يعني إذا كان + +360 +00:35:32,200 --> 00:35:37,480 +لدينا مستخدمين مختلفين وكان علينا الإختيار فقط من + +361 +00:35:37,480 --> 00:35:40,960 +واحد من المستخدمين، هذا هو Capital Rationing انت + +362 +00:35:40,960 --> 00:35:45,280 +تحرر المستخدمين، انت ترى أن هذه المستخدمين باعتبار + +363 +00:35:45,280 --> 00:35:49,560 +IRR تحرر مثلًا باعتبار الـ net present value ومن + +364 +00:35:49,560 --> 00:35:54,740 +ثم تتعامل بين المشروعينمدفع المدفع المدفع المدفع + +365 +00:35:54,740 --> 00:35:57,780 +المدفع المدفع المدفع المدفع المدفع المدفع المدفع + +366 +00:35:57,780 --> 00:36:02,200 +المدفع المدفع المدفع المدفع المدفع المدفع المدفع + +367 +00:36:02,200 --> 00:36:02,500 +المدفع المدفع المدفع المدفع المدفع المدفع المدفع + +368 +00:36:02,500 --> 00:36:04,060 +المدفع المدفع المدفع المدفع المدفع المدفع المدفع + +369 +00:36:04,060 --> 00:36:06,440 +المدفع المدفع المدفع المدفع المدفع المدفع المدفع + +370 +00:36:06,440 --> 00:36:08,960 +المدفع المدفع المدفع المدفع المدفع المدفع المدفع + +371 +00:36:08,960 --> 00:36:10,660 +المدفع المدفع المدفع المدفع المدفع المدفع المدفع + +372 +00:36:10,660 --> 00:36:11,540 +المدفع المدفع المدفع + +373 +00:36:23,180 --> 00:36:26,600 +بسبب أسلحة IRR نقوم باستخدام Modified Internal + +374 +00:36:26,600 --> 00:36:31,260 +Rate of Return وسنريكم كيف نستخدمها لإيقاف إتصال + +375 +00:36:31,260 --> 00:36:40,520 +أو إشارة المال مجموعة مخصوصة مستثمرات إذا كان + +376 +00:36:40,520 --> 00:36:44,520 +لدينا مستثمرات مختلفة نستطيع استخدام IRR نستطيع + +377 +00:36:44,520 --> 00:36:49,060 +استخدام PI نستطيع استخدام عدالة المالto a trade + +378 +00:36:49,060 --> 00:36:50,940 +-off between different projects and different + +379 +00:36:50,940 --> 00:36:55,770 +investmentsالقيم الانتقالية فقط تذكرنا أن القيم + +380 +00:36:55,770 --> 00:37:01,190 +الانتقالية هي القيم الانتقالية هي المساعدة على + +381 +00:37:01,190 --> 00:37:02,210 +المساعدة على المساعدة على المساعدة على المساعدة + +382 +00:37:02,210 --> 00:37:03,070 +على المساعدة على المساعدة على المساعدة على + +383 +00:37:03,070 --> 00:37:03,390 +المساعدة على المساعدة على المساعدة على المساعدة + +384 +00:37:03,390 --> 00:37:04,630 +على المساعدة على المساعدة على المساعدة على + +385 +00:37:04,630 --> 00:37:04,910 +المساعدة على المساعدة على المساعدة على المساعدة + +386 +00:37:04,910 --> 00:37:05,130 +على المساعدة على المساعدة على المساعدة على + +387 +00:37:05,130 --> 00:37:12,870 +على المساعدة على المساعدة على المساعدة + +388 +00:37:12,870 --> 00:37:21,040 +على المساعدة على المساعدة على المساعدOkay see you + +389 +00:37:21,040 --> 00:37:25,240 +ان شاء الله on Saturday what I'm going to do + +390 +00:37:25,240 --> 00:37:32,620 +listen please is to how to write financial report + +391 +00:37:33,670 --> 00:37:37,350 +Okay so I'm inviting you to attend the class of + +392 +00:37:37,350 --> 00:37:43,050 +writing financial reports okay that's it okay انا + +393 +00:37:43,050 --> 00:37:46,830 +بقولكم يعني الحمد لله سلمتكم بالفصل و شكرا كتير + +394 +00:37:46,830 --> 00:37:48,350 +لكم على hosting + diff --git a/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/n2wvBqVJ0_c_raw.srt b/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/n2wvBqVJ0_c_raw.srt new file mode 100644 index 0000000000000000000000000000000000000000..c38a80a1b8868e31eb088f13fc7c334f2dc5d28a --- /dev/null +++ b/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/n2wvBqVJ0_c_raw.srt @@ -0,0 +1,2204 @@ +1 +00:00:18,440 --> 00:00:22,460 +بسم الله الرحمن الرحيم اللي قال فات احنا حكينا عن + +2 +00:00:22,460 --> 00:00:27,600 +ال .. ال taxation أه و we defined the .. the + +3 +00:00:27,600 --> 00:00:32,280 +income tax and the marginal tax okay you try to do + +4 +00:00:32,280 --> 00:00:35,280 +the .. the examples and the questions in your + +5 +00:00:35,280 --> 00:00:39,600 +handbook it's important fine? today I'm going to + +6 +00:00:39,600 --> 00:00:44,260 +talk about the balance sheets and the related .. + +7 +00:00:44,260 --> 00:00:46,680 +the .. the accounts related to the balance sheets + +8 +00:00:47,990 --> 00:00:57,350 +Okay. So now what is the balance sheet? In a + +9 +00:00:57,350 --> 00:01:01,310 +specific dates or period of time because it is now + +10 +00:01:01,310 --> 00:01:06,670 +picture let's see as as she said which is totally + +11 +00:01:06,670 --> 00:01:12,050 +right is a snapshot now it's taking a snapshot of + +12 +00:01:12,050 --> 00:01:14,830 +the financial position let's see for example if I + +13 +00:01:14,830 --> 00:01:19,200 +take a picture now for this classهذه الصورة ستتغير + +14 +00:01:19,200 --> 00:01:26,040 +بعد 1 ثانية إذا أخذ صورة أخرى صورة جديدة لا تتناسب + +15 +00:01:26,040 --> 00:01:32,200 +مع الصورة السابقة لذلك الوضع الانتجار الانتجار + +16 +00:01:32,200 --> 00:01:38,440 +الانتجار + +17 +00:01:38,440 --> 00:01:40,700 +الانتجار الانتجار الانتجار الانتجار الانتجار + +18 +00:01:40,700 --> 00:01:40,860 +الانتجار الانتجار الانتجار الانتجار الانتجار + +19 +00:01:40,860 --> 00:01:40,860 +الانتجار الانتجار الانتجار الانتجار الانتجار + +20 +00:01:40,860 --> 00:01:40,860 +الانتجار الانتجار الانتجار الانتجار الانتجار + +21 +00:01:40,860 --> 00:01:40,860 +الانتجار الانتجار الانتجار الانتجار الانتجار + +22 +00:01:40,860 --> 00:01:40,860 +الانتجار الانتجار الانتجار الانتجار الانتجار + +23 +00:01:40,860 --> 00:01:44,540 +الانتجار الانت + +24 +00:01:47,390 --> 00:01:50,370 +yes raise your voice the income statement contains + +25 +00:01:50,370 --> 00:01:53,850 +the revenue and the expense of the corporation or + +26 +00:01:53,850 --> 00:01:56,230 +the firm but for the balance sheet it contains the + +27 +00:01:56,230 --> 00:02:00,810 +assets in terms of time in terms of time income + +28 +00:02:00,810 --> 00:02:04,130 +statement is for a period of time yeah covers for + +29 +00:02:04,130 --> 00:02:06,690 +one year for instance or one quarter + +30 +00:02:10,220 --> 00:02:14,100 +نعم الآن أو في موقع معين .. نعم أنت محق ، فالـ + +31 +00:02:14,100 --> 00:02:19,300 +balance sheets يعطيك الصورة من الموقع المالي في + +32 +00:02:19,300 --> 00:02:23,460 +موقع معين في وقت محدد ، ولكن الوصولة الاجتماعي + +33 +00:02:23,460 --> 00:02:27,700 +تعطيك النتائج للعمل في السنة السابقة أو القارة + +34 +00:02:27,700 --> 00:02:30,960 +السابقة هناك اختلاف كبير بين ال balance sheets و + +35 +00:02:30,960 --> 00:02:35,480 +الوصولة الاجتماعية حسنًا + +36 +00:02:35,480 --> 00:02:40,310 +، بمعنى عام ال balance sheetsrepresent by the T + +37 +00:02:40,310 --> 00:02:43,890 +account so in your left hand side you have assets + +38 +00:02:43,890 --> 00:02:53,530 +and your right hand side you have liabilities okay + +39 +00:02:53,530 --> 00:02:58,010 +just to give more names for the assets is the uses + +40 +00:02:58,010 --> 00:03:01,630 +of funds and this is the sources of funds + +41 +00:03:04,630 --> 00:03:13,550 +نحن قمنا بتقسيم الميزانيات إلى أربعة مثل هذه هنا + +42 +00:03:13,550 --> 00:03:17,610 +لدينا الميزانيات الحالية وهنا + +43 +00:03:17,610 --> 00:03:21,150 +لدينا الميزانيات التقسيمية وهنا لدينا الميزانيات + +44 +00:03:21,150 --> 00:03:24,370 +التقسيمية او + +45 +00:03:24,370 --> 00:03:29,410 +ميزانيات الحالية ميزانيات + +46 +00:03:29,410 --> 00:03:36,420 +الحالية وقمنا بتقسيمها إلى أربعةالـ Long Term + +47 +00:03:36,420 --> 00:03:45,220 +Liabilities وEquity وShareholder هذه + +48 +00:03:45,220 --> 00:03:51,780 +الأشياء ونستطيع أن نمثل هذا الـ T Account باستخدام + +49 +00:03:51,780 --> 00:03:58,620 +هذه الفormula Total Assets equal Total + +50 +00:03:58,620 --> 00:04:03,970 +Liabilities أو دعنا نقول ليس Total Liabilityأو نعم + +51 +00:04:03,970 --> 00:04:09,030 +تولي المساعدات بالكامل بلس تولي المساعدات بالكامل + +52 +00:04:09,030 --> 00:04:14,190 +اكوتي اكوتي + +53 +00:04:14,190 --> 00:04:21,890 +بخير فهذه هي الفورمولة اذا + +54 +00:04:21,890 --> 00:04:27,150 +تولي المساعدات بالكامل تولي المساعدات بالكامل تولي + +55 +00:04:27,150 --> 00:04:33,810 +المساعدات بالكامل تولي المساعدات بالكامل- total + +56 +00:04:33,810 --> 00:04:39,210 +liabilities okay + +57 +00:04:39,210 --> 00:04:43,450 +so this part is equal to this part minus this part + +58 +00:04:43,450 --> 00:04:50,290 +so equity is equal to total assets minus total + +59 +00:04:50,290 --> 00:04:53,390 +liabilities total liabilities includes the current + +60 +00:04:53,390 --> 00:05:00,470 +liabilities plus the long term liabilities okay + +61 +00:05:02,800 --> 00:05:17,840 +لنعود إلى الحصول على المساعدات الحالية قبل + +62 +00:05:17,840 --> 00:05:21,080 +أن أتكلم عن الحصول على المساعدات الحالية التعاملات + +63 +00:05:21,080 --> 00:05:29,300 +من الواضحات الواضحة هي مجرد قيمة تاريخية لا تنسى + +64 +00:05:29,300 --> 00:05:30,240 +القيمة التاريخية + +65 +00:05:35,960 --> 00:05:40,800 +القيم التاريخية ما يعنيه مقرر على قيم التاريخية + +66 +00:05:40,800 --> 00:05:47,420 +يعني .. نعم مقرر الأسات على قيمهم على قيمهم ماذا + +67 +00:05:47,420 --> 00:05:56,680 +عن الاسات الحالية أو الـ Cash؟ نعم باستخدام هذا + +68 +00:05:56,680 --> 00:06:03,670 +أنت محق لكن فقط لتعريف هذاالقيم التاريخية، جميع + +69 +00:06:03,670 --> 00:06:08,190 +التجارب التي موجودة في الـ Panetsheets مقومة بنسبة + +70 +00:06:08,190 --> 00:06:12,650 +على القيم التاريخية، بإمكانية الـ Cash لأن الـ + +71 +00:06:12,650 --> 00:06:16,410 +Cash هو Cash، ما هي القيم التاريخية لـ 100 دولار؟ + +72 +00:06:16,410 --> 00:06:22,060 +هي 100 دولاربالاستثناء من المال كل التعاملات في + +73 +00:06:22,060 --> 00:06:27,960 +قيمة تاريخية مقررة في قيمة تاريخية مقررة مقررة + +74 +00:06:27,960 --> 00:06:28,400 +مقررة مقررة مقررة مقررة مقررة مقررة مقررة مقررة + +75 +00:06:28,400 --> 00:06:28,760 +مقررة مقررة مقررة مقررة مقررة مقررة مقررة مقررة + +76 +00:06:28,760 --> 00:06:29,040 +مقررة مقررة مقررة مقررة مقررة مقررة مقررة مقررة + +77 +00:06:29,040 --> 00:06:33,460 +مقررة مقررة مقررة مقررة مقررة مقررة مقررة مقررة + +78 +00:06:33,460 --> 00:06:38,540 +مقررة مقررة مقررة + +79 +00:06:48,270 --> 00:06:56,110 +the machine is now say for instance fifty thousand + +80 +00:06:56,110 --> 00:07:01,370 +dollar look at the machine the machine is fifty + +81 +00:07:01,370 --> 00:07:04,550 +thousand dollar now or let's say the building or + +82 +00:07:04,550 --> 00:07:10,310 +the machine the building is + +83 +00:07:10,310 --> 00:07:14,910 +seventy thousand dollar now let's focus at the + +84 +00:07:14,910 --> 00:07:23,230 +buildingهذا مقرر بحسب قيمة التاريخ المبنى مقرر + +85 +00:07:23,230 --> 00:07:27,030 +بحسب قيمة التاريخ المبنى مقرر بحسب قيمة تاريخ + +86 +00:07:27,030 --> 00:07:27,610 +المبنى مقرر بحسب قيمة تاريخ المبنى مقرر بحسب قيمة + +87 +00:07:27,610 --> 00:07:29,590 +تاريخ المبنى مقرر بحسب قيمة تاريخ المبنى مقرر بحسب + +88 +00:07:29,590 --> 00:07:31,310 +قيمة تاريخ المبنى مقرر بحسب قيمة تاريخ المبنى مقرر + +89 +00:07:31,310 --> 00:07:38,730 +بحسب قيمة تاريخ المبنى مقرر بحسب قيمة تاريخ المبنى + +90 +00:07:38,730 --> 00:07:44,990 +مقرر بحسب قيمة تاريخ المبنى مقرر بحسب قيمة تاريخ + +91 +00:07:44,990 --> 00:07:54,810 +المبنى مقرر بحبعد الانتقال ماهو الانتقال؟ لماذا + +92 +00:07:54,810 --> 00:08:02,510 +الانتقال مهم؟ لأن المواد تتخلص من وقتها لأن المواد + +93 +00:08:02,510 --> 00:08:08,310 +تتخلص من وقتها لأن المواد تتخلص من وقتها لأن + +94 +00:08:08,310 --> 00:08:09,430 +المواد تتخلص من وقتها لأن المواد تتخلص من وقتها + +95 +00:08:09,430 --> 00:08:09,470 +لأن المواد تتخلص من وقتها لأن المواد تتخلص من + +96 +00:08:09,470 --> 00:08:09,470 +وقتها لأن المواد تتخلص من وقتها لأن المواد تتخلص + +97 +00:08:09,470 --> 00:08:09,470 +من وقتها لأن المواد تتخلص من وقتها لأن المواد + +98 +00:08:09,470 --> 00:08:09,510 +تتخلص من وقتها لأن المواد تتخلص من وقتها لأن + +99 +00:08:09,510 --> 00:08:09,910 +المواد تتخلص من وقتها لأن المواد تتخلص من وقتها ل + +100 +00:08:11,840 --> 00:08:16,840 +عن هذا الشركة أو المديرين يجب أن يفكروا أنه بعد + +101 +00:08:16,840 --> 00:08:21,780 +مرور وقت يجب أن يشتروا مبنى جديد أو جهاز جديد حسنا + +102 +00:08:21,780 --> 00:08:29,040 +فالأمر الأن هو 70 ألف دولار هذا بعد التقرير بعد + +103 +00:08:29,040 --> 00:08:37,500 +التقرير ربما هذا كان شرح قبل ثلاث سنة + +104 +00:08:40,710 --> 00:08:47,490 +وقيمة هذا كانت 100 ألف دولار وكانت مدفوعة ل 10 سنة + +105 +00:08:47,490 --> 00:08:55,970 +1,2,3,4,5 إلى 10 سنة ، لذلك كل عام يجب أن ندفع 10 + +106 +00:08:55,970 --> 00:09:02,770 +ألف دولار هذا لثلاث سنوات 100 ألف دولار ، لذلك + +107 +00:09:02,770 --> 00:09:11,320 +ندفع 10 لكل عام إلى اليوم 70 ألف دولارOkay. So it + +108 +00:09:11,320 --> 00:09:15,200 +means after 10 years, we will have $100,000 + +109 +00:09:15,200 --> 00:09:21,720 +thinking that we will buy a new building. This is + +110 +00:09:21,720 --> 00:09:26,580 +the idea of depreciation. Now, this is not the + +111 +00:09:26,580 --> 00:09:32,120 +story now. My question is now, today according to + +112 +00:09:32,120 --> 00:09:34,840 +the our book value, which is the historical value, + +113 +00:09:35,640 --> 00:09:40,920 +so the new building here is $70,000إذا تنظر إلى + +114 +00:09:40,920 --> 00:09:46,160 +هذا هو قيمة الكتابة قيمة الكتابة هي نفسها قيمة + +115 +00:09:46,160 --> 00:09:53,840 +التاريخية ولكن المشكلة إذا ننظر إلى قيمة السوق + +116 +00:09:53,840 --> 00:09:56,920 +لعملية + +117 +00:09:56,920 --> 00:10:05,320 +المبنى ربما قيمة السوق 150 ألف دولار وهي مختلفةهذا + +118 +00:10:05,320 --> 00:10:07,440 +هو المشكلة في الـ Balance Sheet في الـ Balance + +119 +00:10:07,440 --> 00:10:12,280 +Sheet نحن مقيمين التجارب على قيمة التاريخ وليس على + +120 +00:10:12,280 --> 00:10:19,860 +قيمة السوق، حسنًا؟ فالـ + +121 +00:10:19,860 --> 00:10:25,260 +Balance Sheet ليس يعطيك ما هي الموقع الواقعي للعمل + +122 +00:10:25,260 --> 00:10:29,560 +هناك، + +123 +00:10:29,560 --> 00:10:29,800 +حسنًا؟ + +124 +00:10:45,130 --> 00:10:49,750 +الان كما أشرح في الـ Balance Sheets، هذه أساتية + +125 +00:10:49,750 --> 00:10:54,990 +عامة وهذه قيمة عامة وكما قمنا بتقسيمها لثلاثة قطع + +126 +00:10:54,990 --> 00:10:59,650 +في القيمة العامة و2 قطع في الأساتية العامة + +127 +00:10:59,650 --> 00:11:03,430 +الأساتية العامة تحتوي على الأساتيات الحالية + +128 +00:11:03,430 --> 00:11:09,150 +والأساتيات العامة، الأساتيات الحالية تحتوي على + +129 +00:11:09,150 --> 00:11:11,490 +الأساتيات العامة التي تحتوي على الأساطيات العامة + +130 +00:11:11,490 --> 00:11:16,850 +التي تحتوي على الأساطيات العامةOkay so these are + +131 +00:11:16,850 --> 00:11:26,630 +short term assets short assets or let's say liquid + +132 +00:11:26,630 --> 00:11:31,550 +assets comparing with the with the long term + +133 +00:11:31,550 --> 00:11:36,670 +assets so what it means liquid يعني what it means + +134 +00:11:36,670 --> 00:11:40,530 +liquid some people saying something okay + +135 +00:11:44,740 --> 00:11:48,580 +السرعة التي تستطيع تحويل مصادر إلى مصادر حسنًا، + +136 +00:11:48,580 --> 00:11:55,100 +ولكن هذا ليس .. دعنا نقول المفهوم الوطني لهذا، أنت + +137 +00:11:55,100 --> 00:11:59,480 +محق، هو السرعة التي تستطيع تحويل مصادر إلى مصادر، + +138 +00:11:59,480 --> 00:12:05,440 +هذا حسنًا، بدون تغييرات في السعر، بدون تغييرات أو + +139 +00:12:05,440 --> 00:12:11,300 +بدون معلومات عن قيمة المصادرأو تأثير كبير على قيمة + +140 +00:12:11,300 --> 00:12:15,980 +الحيوانات دعونا نرى على سبيل المثال أعطيك مثلا فقط + +141 +00:12:15,980 --> 00:12:22,260 +مثال صغير فقط هنا إذا كان عليك أن ترى ما يعنيه + +142 +00:12:22,260 --> 00:12:28,820 +المال إذا كان لديك اتصالات موبايل اتصالات + +143 +00:12:28,820 --> 00:12:31,160 +موبايل اتصالات اتصالات موبايل اتصالات موبايل + +144 +00:12:31,160 --> 00:12:33,560 +اتصالات موبايل اتصالات موبايل اتصالات موبايل + +145 +00:12:33,560 --> 00:12:33,720 +اتصالات موبايل اتصالات موبايل اتصالات موبايل + +146 +00:12:33,720 --> 00:12:35,280 +اتصالات موبايل اتصالات موبايل اتصالات موبايل + +147 +00:12:35,280 --> 00:12:38,020 +اتصالات موبايل اتصالات موبايل اتصالات موبايل + +148 +00:12:38,020 --> 00:12:38,420 +اتصالات + +149 +00:12:41,040 --> 00:12:47,560 +وانت قررت تسوي من هناك وهو أنك تستطيع تسوي أسهل من + +150 +00:12:47,560 --> 00:12:56,780 +الجالكسيا لذلك هي أكتر مليونية يمكنك بسهولة تسوي + +151 +00:12:56,780 --> 00:13:02,800 +الجالكسيا إلى السوق بدون اشكال على السعر ولكن اذا + +152 +00:13:02,800 --> 00:13:06,980 +كنت تريد تسوي سوني تستطيع تفعل هذا ولكن يمكنك أن + +153 +00:13:06,980 --> 00:13:13,400 +تنتظر لوقت طويلويمكن أن يتأثر على قيمة سوني، + +154 +00:13:13,400 --> 00:13:20,760 +لماذا؟ لأن الجالاكسي ممكن تسويقه، ممكن تسويقه، + +155 +00:13:20,760 --> 00:13:29,940 +ممكن تسويقه من سوني، لهذا السبب الجالاكسي أكتر + +156 +00:13:29,940 --> 00:13:34,880 +مدعوم من سونيوإذا تنظر إلى المصادر الحالية + +157 +00:13:34,880 --> 00:13:39,440 +بالمقارنة بالمصادر السلوكية المصادر الحالية هي + +158 +00:13:39,440 --> 00:13:43,040 +أكتر من المصادر السلوكية المصادر السلوكية المصادر + +159 +00:13:43,040 --> 00:13:43,940 +السلوكية المصادر السلوكية المصادر السلوكية المصادر + +160 +00:13:43,940 --> 00:13:43,940 +السلوكية المصادر السلوكية المصادر السلوكية المصادر + +161 +00:13:43,940 --> 00:13:44,600 +السلوكية المصادر السلوكية المصادر السلوكية المصادر + +162 +00:13:44,600 --> 00:13:47,580 +السلوكية المصادر السلوكية المصادر السلوكية المصادر + +163 +00:13:47,580 --> 00:13:49,400 +السلوكية المصادر السلوكية المصادر السلوكية المصادر + +164 +00:13:49,400 --> 00:13:56,280 +السلوكية المصادر + +165 +00:13:56,280 --> 00:14:02,070 +السلوكية المصادر السلوكيةالحصول على حصار أقل من + +166 +00:14:02,070 --> 00:14:05,630 +المال من المال من المال من المال من المال من المال + +167 +00:14:05,630 --> 00:14:06,590 +من المال من المال من المال من المال من المال من + +168 +00:14:06,590 --> 00:14:07,690 +المال من المال من المال من المال من المال من المال + +169 +00:14:07,690 --> 00:14:07,690 +من المال من المال من المال من المال من المال من + +170 +00:14:07,690 --> 00:14:07,730 +المال من المال من المال من المال من المال من المال + +171 +00:14:07,730 --> 00:14:07,990 +من المال من المال من المال من المال من المال من + +172 +00:14:07,990 --> 00:14:08,550 +المال من المال من المال من المال من المال من المال + +173 +00:14:08,550 --> 00:14:08,970 +من المال من المال من المال من المال من المال من + +174 +00:14:08,970 --> 00:14:09,190 +المال من المال من المال من المال من المال من المال + +175 +00:14:09,190 --> 00:14:10,670 +من المال من المال من المال من المال من المال من + +176 +00:14:10,670 --> 00:14:10,670 +المال من المال من المال من المال من المال من المال + +177 +00:14:10,670 --> 00:14:10,670 +من المال من المال من المال من المال من المال من + +178 +00:14:10,670 --> 00:14:14,830 +المال من المال من المال من المال من + +179 +00:14:14,830 --> 00:14:15,370 +المال + +180 +00:14:29,300 --> 00:14:35,360 +الحصة المستقبلية يمكن أن تكون 80% من الحصة + +181 +00:14:35,360 --> 00:14:40,260 +المستقبلية 60% من الحصة المستقبلية كحصة مستقبلية + +182 +00:14:40,260 --> 00:14:47,300 +تستطيع تحويلها إلى حصة مستقبلية تستطيع + +183 +00:14:47,300 --> 00:14:48,420 +تحويلها إلى حصة مستقبلية تستطيع تحويلها إلى حصة + +184 +00:14:48,420 --> 00:14:52,080 +مستقبلية تستطيع تحويلها إلى حصة مستقبلية تستطيع + +185 +00:14:52,080 --> 00:14:53,200 +تحويلها إلى حصة مستقبلية تستطيع تحويلها إلى حصة + +186 +00:14:53,200 --> 00:14:53,680 +مستقبلية تستطيع تحويلها إلى حصة مستقبلية + +187 +00:14:57,760 --> 00:15:06,020 +أنا أقول إنها أقل ملحوظة، إنها أقل ملحوظة أساتز، + +188 +00:15:06,020 --> 00:15:11,880 +إنها ملحوظة، لكنها أقل ملحوظة، هذا يعني أننا قد + +189 +00:15:11,880 --> 00:15:15,680 +نحتاج وقت أكتر لتحويلها إلى المال، لأن الانفجار + +190 +00:15:15,680 --> 00:15:19,800 +أحيانًا قد يكون مواد عامة، لذلك نحتاج لتحويل مواد + +191 +00:15:19,800 --> 00:15:24,900 +عامة إلى شركات أو أشركات، ثم أشركات إلى شركات، ثم + +192 +00:15:24,900 --> 00:15:31,270 +شركات إلى المالهذا هو عملية تحويل المصادر إلى + +193 +00:15:31,270 --> 00:15:36,650 +المال مثل المصادر، المصادر مستحيلة للحصول عليها + +194 +00:15:36,650 --> 00:15:43,310 +مثل الـ debtors أو مصادر الديتز يجب أن تجمع المال + +195 +00:15:43,310 --> 00:15:53,330 +من السوق أو من الناس ثم تحويلها إلى المال المصادر + +196 +00:15:55,880 --> 00:15:58,760 +التي تحتوي على المصادر، المصادر، المبنى، المصادر + +197 +00:15:58,760 --> 00:16:06,600 +ومصادر غير مستخدمين هذه مصادر طويلة وقلت إن هذه + +198 +00:16:06,600 --> 00:16:12,080 +فرصة شرح للعمل لماذا هي مصادر طويلة؟ لأنها + +199 +00:16:12,080 --> 00:16:19,520 +لإستخدام أكتر من عام واحدمقارنة مع الواحدات + +200 +00:16:19,520 --> 00:16:21,980 +الحالية الواحدات الحالية هي في أقل من عام واحد + +201 +00:16:21,980 --> 00:16:25,480 +السنة الواحدات السعودية نستخدمها ليس لتساوي + +202 +00:16:25,480 --> 00:16:33,000 +نستخدمها لتصنيع واحدة أخرى لتصنيع مصادر لتصنيع + +203 +00:16:33,000 --> 00:16:34,880 +الوضع والوضع والوضع والوضع والوضع والوضع والوضع + +204 +00:16:34,880 --> 00:16:37,500 +والوضع والوضع والوضع والوضع والوضع والوضع والوضع + +205 +00:16:37,500 --> 00:16:39,140 +والوضع والوضع والوضع والوضع والوضع والوضع والوضع + +206 +00:16:39,140 --> 00:16:39,380 +والوضع والوضع والوضع والوضع والوضع والوضع والوضع + +207 +00:16:39,380 --> 00:16:43,420 +والوضع والوضع والوضع والوضع والوضع والوضع والوضع + +208 +00:16:44,030 --> 00:16:48,310 +أنت تشتري الاسلحة لأستثمار هذه الاسلحة ستصنع شيء + +209 +00:16:48,310 --> 00:16:53,930 +ثم تسعى هذه الأجهزة وما إلى ذلك أسلحة، أرض وأشياء + +210 +00:16:53,930 --> 00:17:00,630 +أخرى مصادرة على أسلحة فهذا هو الجانب اليساري إذا + +211 +00:17:00,630 --> 00:17:05,470 +كنت تنظر إلى الجانب اليساري لدينا المساعدات + +212 +00:17:05,470 --> 00:17:10,650 +الحالية مرة أخرى المساعدات الحالية هي المساعدات + +213 +00:17:10,650 --> 00:17:16,470 +قصيرةوالسلسلات القصيرة تحتوي على مستخدمات مستخدمات + +214 +00:17:16,470 --> 00:17:19,090 +مستخدمات مستخدمات مستخدمات مستخدمات مستخدمات + +215 +00:17:19,090 --> 00:17:19,870 +مستخدمات مستخدمات مستخدمات مستخدمات مستخدمات + +216 +00:17:19,870 --> 00:17:19,870 +مستخدمات مستخدمات مستخدمات مستخدمات مستخدمات + +217 +00:17:19,870 --> 00:17:20,530 +مستخدمات مستخدمات مستخدمات مستخدمات مستخدمات + +218 +00:17:20,530 --> 00:17:21,270 +مستخدمات مستخدمات مستخدمات مستخدمات مستخدمات + +219 +00:17:21,270 --> 00:17:27,230 +مستخدمات مستخدمات مستخدمات مستخدمات مستخدمات + +220 +00:17:27,230 --> 00:17:31,310 +مستخدمات + +221 +00:17:31,310 --> 00:17:35,590 +مستخدمات مستخدمات + +222 +00:17:36,490 --> 00:17:40,670 +هذه المنطقة مؤسسة من هذه المنطقة المواصفات + +223 +00:17:40,670 --> 00:17:44,590 +الحالية، نعود إلى هنا هذه المواصفات الحالية وهذه + +224 +00:17:44,590 --> 00:17:48,270 +المساعدات الحالية، لذلك نمسك مواصفات الحالية من + +225 +00:17:48,270 --> 00:17:54,430 +المساعدات الحالية الفرق بينهم، فالفرق بين هذه + +226 +00:17:54,430 --> 00:18:00,190 +المنطقة وهذه المنطقة هي نت ويركينج كابيتال + +227 +00:18:16,870 --> 00:18:24,250 +بشكل عام، هذا المصادر التواصلية هذا + +228 +00:18:24,250 --> 00:18:29,290 +المصادر التواصلية مصادر التواصلية هي اكتشاف + +229 +00:18:29,290 --> 00:18:32,230 +المصادر التواصلية او مصادر المصادر التواصلية او + +230 +00:18:32,230 --> 00:18:34,270 +مصادر المصادر التواصلية او مصادر المصادر التواصلية + +231 +00:18:34,270 --> 00:18:36,230 +او مصادر المصادر التواصلية او مصادر المصادر + +232 +00:18:36,230 --> 00:18:36,910 +التواصلية او مصادر المصادر التواصلية او مصادر + +233 +00:18:36,910 --> 00:18:36,970 +المصادر التواصلية او مصادر المصادر التواصلية او + +234 +00:18:36,970 --> 00:18:38,930 +مصادر المصادر التواصلية او مصادر المصادر التواصلية + +235 +00:18:38,930 --> 00:18:45,990 +او مصادر المصادر التواصلية او مصادر المصاد + +236 +00:18:48,400 --> 00:18:52,680 +this is good for the business many stars but if + +237 +00:18:52,680 --> 00:18:56,140 +the answer is negative it means we don't have + +238 +00:18:56,140 --> 00:18:59,420 +stars it means this is very bad to the business + +239 +00:18:59,420 --> 00:19:05,860 +this is a negative signs to the healthy situation + +240 +00:19:05,860 --> 00:19:09,280 +of the business so it's early indicator for the + +241 +00:19:09,280 --> 00:19:13,180 +business that we may have problems or challenges + +242 +00:19:13,180 --> 00:19:17,500 +in managing this business okay + +243 +00:19:25,570 --> 00:19:28,730 +الفرق بين الوثيقة الحالية والوثيقة الحالية هي + +244 +00:19:28,730 --> 00:19:38,850 +المهم أن نرى كيف نستعيد الوثيقة الحالية هذا يعني + +245 +00:19:38,850 --> 00:19:43,750 +أن الوثيقة الحالية يجب أن تتسلق؟ نعم لأن الوثيقة + +246 +00:19:43,750 --> 00:19:47,440 +الحالية .. أسف قولها مرة أخرىالأموال الحالية يجب + +247 +00:19:47,440 --> 00:19:50,820 +أن تتجاوز .. تتجاوز المساعدات الحالية كيف نجد + +248 +00:19:50,820 --> 00:19:55,480 +الأموال الحالية من المساعدات الحالية؟ نجد + +249 +00:19:55,480 --> 00:19:58,120 +المساعدات الحالية من المساعدات الحالية نقوم + +250 +00:19:58,120 --> 00:20:00,420 +باستخدام المساعدة ونقوم بعمل عملية عملية عملية + +251 +00:20:00,420 --> 00:20:06,340 +عملية عملية عملية عملية عملية عملية عملية عملية + +252 +00:20:06,340 --> 00:20:06,440 +عملية عملية عملية عملية عملية عملية عملية عملية + +253 +00:20:06,440 --> 00:20:06,440 +عملية عملية عملية عملية عملية عملية عملية عملية + +254 +00:20:06,440 --> 00:20:06,440 +عملية عملية عملية عملية عملية عملية عملية عملية + +255 +00:20:06,440 --> 00:20:15,480 +عملية عملية عملية عملية عملية عملية عملية عمل + +256 +00:20:16,130 --> 00:20:19,810 +بسبب أن الـ networking capital يعطيك plus أو + +257 +00:20:19,810 --> 00:20:25,290 +minus، إلى مستوى ما يكون plus بخير و minus بخير أو + +258 +00:20:25,290 --> 00:20:28,550 +مقبول، على سبيل المثال، إذا كان لديك إضاءة أحمر، + +259 +00:20:28,550 --> 00:20:33,550 +إلى مستوى ما يكون أحمر أحمر، ترى؟ أو إلى مستوى ما + +260 +00:20:33,550 --> 00:20:38,210 +يكون أحمر أحمر أكترفالـ positive .. الـ plus أو + +261 +00:20:38,210 --> 00:20:42,590 +الـ minus ليس يعطيك الـ to what extent this is .. + +262 +00:20:42,590 --> 00:20:46,610 +positive هو حسنًا، فالـ positive نسميه positive، + +263 +00:20:46,610 --> 00:20:48,210 +فهو حسنًا، فمع كم أكتر أكتر أكتر أكتر أكتر أكتر + +264 +00:20:48,210 --> 00:20:49,150 +أكتر أكتر أكتر أكتر أكتر أكتر أكتر أكتر أكتر أكتر + +265 +00:20:49,150 --> 00:20:51,490 +أكتر أكتر أكتر أكتر أكتر أكتر أكتر أكتر أكتر أكتر + +266 +00:20:51,490 --> 00:20:52,450 +أكتر أكتر أكتر أكتر أكتر أكتر أكتر أكتر أكتر أكتر + +267 +00:20:52,450 --> 00:21:05,030 +أكتر أكتر أكتر أكتر أكتر أك + +268 +00:21:06,350 --> 00:21:11,250 +20 ألف دولار سنرى إنه حسنًا لكن إذا كانت المصادر + +269 +00:21:11,250 --> 00:21:19,890 +التواصلية 100 ألف دولار ما هو أفضل هذا أو هذا؟ نعم + +270 +00:21:19,890 --> 00:21:28,270 +100 ألف ربما صح و ربما خطأ لماذا؟ قرار المشروع + +271 +00:21:28,270 --> 00:21:34,050 +دعونا نرى قرار المشروع انظر إلى هذا انا أشرح هذا + +272 +00:21:34,050 --> 00:21:40,160 +في الاناليز الماليةالصحيحين السياسيين يجلسون في + +273 +00:21:40,160 --> 00:21:44,800 +عقلهم ماهي قيمة المساعدة المقبولة أو ماهي قيمة + +274 +00:21:44,800 --> 00:21:47,360 +المساعدة المقبولة لـ Networking Capital قيمة + +275 +00:21:47,360 --> 00:21:53,100 +المساعدة المقبولة موجودة في المنطقة هنا على سبيل + +276 +00:21:53,100 --> 00:21:57,000 +المثال يقولون هذا 10 ألف دولار وهذا 30 ألف دولار + +277 +00:21:57,000 --> 00:22:00,640 +إذا + +278 +00:22:00,640 --> 00:22:05,400 +كانت Networking Capital موجودة في هذه المنطقة فهي + +279 +00:22:05,400 --> 00:22:11,050 +بخيرإذا كانت هذه المنطقة موجودة في هذه المنطقة، + +280 +00:22:11,050 --> 00:22:14,870 +وهذا يعني أن قيمة التواصل هي مثل هذا، فهي تقريبًا + +281 +00:22:14,870 --> 00:22:20,450 +تذهب إلى نقل، فهذه المنطقة في نقل، لذلك يمكن أن + +282 +00:22:20,450 --> 00:22:24,610 +يكونوا يجلسوا في Tresk، لذلك يحاولوا أن يبقوا قيمة + +283 +00:22:24,610 --> 00:22:29,680 +التواصل في هذه المنطقة، وإذاالسياسة المالية تتجاوز + +284 +00:22:29,680 --> 00:22:33,160 +30 ألف دولار، وهذا يعني أنهم لديهم إيقاف أكتر + +285 +00:22:33,160 --> 00:22:39,300 +وإنهم يفقدوا فرصة الاستثمار، هذا لا يعني أنك لديك + +286 +00:22:39,300 --> 00:22:44,780 +إيقاف عالي، هذا بخير للعمل، هذا يعني أن إذا كان + +287 +00:22:44,780 --> 00:22:48,900 +لديك إيقاف أكتر من ما تريده، فهذا يعني أنك تفقد + +288 +00:22:48,900 --> 00:22:55,410 +فرصة الاستثمارthis is why after this part after 30 + +289 +00:22:55,410 --> 00:23:03,010 +thousands we are thinking here to invest to + +290 +00:23:03,010 --> 00:23:11,790 +invest you may invest in short or in long it + +291 +00:23:11,790 --> 00:23:18,220 +depends onللموضوع إذا كنت تبقى نفسك عامًا أعلى هذه + +292 +00:23:18,220 --> 00:23:22,100 +السرعة فهو بخير لإستثمارات طويلة إذا كان هذا عامًا + +293 +00:23:22,100 --> 00:23:25,860 +فهو بخير لإستثمارات قصيرة فهو بخير لإستثمارات + +294 +00:23:25,860 --> 00:23:25,860 +قصيرة فهو بخير لإستثمارات قصيرة فهو بخير + +295 +00:23:25,860 --> 00:23:25,880 +لإستثمارات قصيرة فهو بخير لإستثمارات قصيرة فهو + +296 +00:23:25,880 --> 00:23:28,060 +بخير لإستثمارات قصيرة فهو بخير لإستثمارات قصيرة + +297 +00:23:28,060 --> 00:23:35,020 +فهو بخير لإستثمارات قصيرة فهو بخير لإستثمارات + +298 +00:23:35,020 --> 00:23:41,540 +قصيرة فهو بخير لإستثمارات قصيرة فهو بخير لإستثمار + +299 +00:23:42,520 --> 00:23:45,600 +preferable if you are floating above this place + +300 +00:23:45,600 --> 00:23:49,480 +for just season for summer for instance okay then + +301 +00:23:49,480 --> 00:23:52,140 +just invest in summer and you can liquidate it in + +302 +00:23:52,140 --> 00:23:56,060 +winter or in autumn so this is the idea of + +303 +00:23:56,060 --> 00:24:02,300 +networking capital okay any + +304 +00:24:02,300 --> 00:24:02,640 +question? + +305 +00:24:14,390 --> 00:24:20,250 +هل لديك أسئلة عن شريط البيانات؟ نحن + +306 +00:24:20,250 --> 00:24:24,010 +نتكلم عن المساعدات الحالية في حياته الحيوانات + +307 +00:24:24,010 --> 00:24:29,470 +الحالية الآن للمساعدات السلوكية المساعدات السلوكية + +308 +00:24:29,470 --> 00:24:34,430 +المساعدات المساعدة تدفع المساعدات المحفظة دعونا + +309 +00:24:34,430 --> 00:24:39,990 +نعود إلى هذا إذا + +310 +00:24:39,990 --> 00:24:45,110 +كنا نتكلم عن هذه المساعدات الحاليةوهو الـ long + +311 +00:24:45,110 --> 00:24:51,390 +term liabilities الـ long term liabilities من + +312 +00:24:51,390 --> 00:24:55,290 +الأموال المحفوظة والأموال الحالية من الأموال + +313 +00:24:55,290 --> 00:24:58,570 +الحالية هذا ما يسمونه في الهدف الهدف المحفوظ هو + +314 +00:24:58,570 --> 00:25:05,110 +الهدف المحفوظ الهدف المحفوظ + +315 +00:25:05,110 --> 00:25:08,830 +هو الهدف المحفوظ هو الهدف المحفوظ المشكلة أنه + +316 +00:25:08,830 --> 00:25:14,090 +أحيانًانجد الأموال الحالية .. أسف .. الأموال + +317 +00:25:14,090 --> 00:25:20,170 +المستقبلية من المساعدات الحالية نعم وما نسميه هذا + +318 +00:25:20,170 --> 00:25:28,650 +.. نسميه هذا عملية التدخل العضوى نعم، إنهم يأخذون + +319 +00:25:28,650 --> 00:25:35,810 +المخاطر، هذا عضوى لماذا يفعلون هذا؟ لماذا .. بعض + +320 +00:25:35,810 --> 00:25:41,220 +المديرين .. المديرات الماليةهي تدفع المصادر + +321 +00:25:41,220 --> 00:25:45,940 +المقاومة من المساعدات الحالية لماذا؟ + +322 +00:25:45,940 --> 00:25:54,520 +هل تعرفين لماذا؟ لماذا تدفع المصادر المقاومة من + +323 +00:25:54,520 --> 00:25:58,420 +المساعدات الحالية ماهي الفرق بين المساعدات الحالية + +324 +00:25:58,420 --> 00:26:04,140 +ومساعدات طويلة بالنسبة لسعر المساعدة التي تدفع + +325 +00:26:04,140 --> 00:26:10,150 +المساعدة الحالية أو المساعدة الطويلة؟السلسلات + +326 +00:26:10,150 --> 00:26:12,710 +السلسلة السلسلة السلسلة السلسلة السلسلة السلسلة + +327 +00:26:12,710 --> 00:26:17,390 +السلسلة السلسلة السلسلة السلسلة + +328 +00:26:17,390 --> 00:26:19,890 +السلسلة السلسلة السلسلة السلسلة السلسلة السلسلة + +329 +00:26:19,890 --> 00:26:19,890 +السلسلة السلسلة السلسلة السلسلة السلسلة السلسلة + +330 +00:26:19,890 --> 00:26:25,230 +السلسلة السلسلة السلسلة السلسلة السلسلة السلسلة + +331 +00:26:25,230 --> 00:26:29,230 +السلسلة السلسلة السلسلة السلسلة السلسلة السلسلة + +332 +00:26:29,230 --> 00:26:34,850 +السلسلة السلسلة السلسلة السلسلة السلسلة السلسلة + +333 +00:26:34,850 --> 00:26:36,030 +السلسلة السلسلة السلسلة السلسلة السلسلة السلسلة + +334 +00:26:36,030 --> 00:26:36,030 +السلسلة السلسلة السلسلة السلسلة السلسلة السلسلة + +335 +00:26:36,030 --> 00:26:41,250 +السلسلة السلسلة السللأن في مقتصر قصير من الوقت، + +336 +00:26:41,250 --> 00:26:44,490 +كانوا يجب أن يدفعوا أكتر من المال، وهذا هو السبب + +337 +00:26:44,490 --> 00:26:47,110 +في أنها عضوية، لذلك قاموا بالتضغط على الأسعار + +338 +00:26:47,110 --> 00:26:51,750 +لتنمية أكتر من المال، لكي يستعينوا المساعدات + +339 +00:26:51,750 --> 00:26:55,510 +الحالية، لأنهم يشتروا على أجهزة وأجهزة من + +340 +00:26:55,510 --> 00:26:59,910 +المساعدات الحاليةإلا إذا كنت تستخدم دولة لعام 10 + +341 +00:26:59,910 --> 00:27:04,050 +سنة فإنك تستخدم دولة لعام واحد لعام واحد لعام واحد + +342 +00:27:04,050 --> 00:27:10,990 +لعام يعني أنك تضغط على مصالحك أنت تضغط على الأسعار + +343 +00:27:10,990 --> 00:27:15,090 +لتصنع المزيد من المال ويمكنك أن تتعامل مع المحاولة + +344 +00:27:15,090 --> 00:27:20,570 +فهذه هي الفرق بين الانتجار الهجومي والانتجار + +345 +00:27:20,570 --> 00:27:23,990 +المحافظي و + +346 +00:27:25,600 --> 00:27:28,980 +القرارات المستقبلية أو القرارات المستقبلية كما قلت + +347 +00:27:28,980 --> 00:27:34,120 +إنها وقت أكتر ومعروفة أكتر من القرارات المستقبلية + +348 +00:27:34,120 --> 00:27:36,980 +على سبيل المثال إذا ذهبت إلى الحكومة وكانت تريد أن + +349 +00:27:36,980 --> 00:27:42,200 +تشتري منزل لديك اختيارين اما القرارات المستقبلية + +350 +00:27:42,200 --> 00:27:45,740 +أو القرارات المستقبلية بعض الناس تذهب إلى القرارات + +351 +00:27:45,740 --> 00:27:48,620 +المستقبلية حسنا هذا بخير ولكن المشكلة أنك يجب أن + +352 +00:27:48,620 --> 00:27:53,460 +تدفع أكتر من المال في فترة قصيرة من الوقت + +353 +00:27:56,500 --> 00:27:59,520 +السلسلات السلسلات السلسلات السلسلات السلسلات + +354 +00:27:59,520 --> 00:27:59,940 +السلسلات السلسلات السلسلات السلسلات السلسلات + +355 +00:27:59,940 --> 00:28:05,380 +السلسلات السلسلات السلسلات السلسلات السلسلات + +356 +00:28:05,380 --> 00:28:09,000 +السلسلات السلسلات السلسلات السلسلات السلسلات + +357 +00:28:09,000 --> 00:28:12,120 +السلسلات السلسلات السلسلات السلسلات السلسلات + +358 +00:28:12,120 --> 00:28:14,140 +السلسلات السلسلات السلسلات السلسلات السلسلات + +359 +00:28:14,140 --> 00:28:16,880 +السلسلات السلسلات السلسلات السلسلات السلسلات + +360 +00:28:16,880 --> 00:28:19,880 +السلسلات السلسلات السلسلات السلسلات السلسلات + +361 +00:28:19,880 --> 00:28:25,720 +السلسلات السلسلات السلسلات السلسلات السلس + +362 +00:28:28,950 --> 00:28:34,170 +العامة الشركات التي هي الأخيرة اللتي تحتوي على + +363 +00:28:34,170 --> 00:28:37,350 +قيمة الـ Bar من الشركات أو من الشركات أو من + +364 +00:28:37,350 --> 00:28:37,730 +الشركات أو من الشركات أو من الشركات أو من الشركات + +365 +00:28:37,730 --> 00:28:41,070 +أو من الشركات أو من الشركات أو من الشركات أو من + +366 +00:28:41,070 --> 00:28:42,310 +الشركات أو من الشركات أو من الشركات أو من الشركات + +367 +00:28:42,310 --> 00:28:44,710 +أو من الشركات أو من الشركات أو من الشركات أو من + +368 +00:28:44,710 --> 00:28:45,530 +الشركات أو من الشركات أو من الشركات أو من الشركات + +369 +00:28:45,530 --> 00:28:46,470 +أو من الشركات أو من الشركات أو من الشركات أو من + +370 +00:28:46,470 --> 00:28:48,130 +الشركات أو من الشركات أو من الشركات أو من الشركات + +371 +00:28:48,130 --> 00:28:49,350 +أو من الشركات أو من الشركات أو من الشركات أو من + +372 +00:28:49,350 --> 00:28:50,050 +الشركات أو من الشركات أو من الشركات أو من الشركات + +373 +00:28:50,050 --> 00:28:51,830 +أو من الشركات أو من الشركات أو من الشركات أو من + +374 +00:28:51,830 --> 00:29:00,270 +الشركات أو من الشركات أو من الشركات أوOkay and you + +375 +00:29:00,270 --> 00:29:04,970 +have face value sometimes you have initial value + +376 +00:29:04,970 --> 00:29:08,130 +Okay + +377 +00:29:08,130 --> 00:29:12,130 +what is the difference between the bar value and + +378 +00:29:12,130 --> 00:29:19,810 +the face value The + +379 +00:29:19,810 --> 00:29:26,750 +bar value this is an accounting The + +380 +00:29:26,750 --> 00:29:27,710 +bar value of the stock + +381 +00:29:32,170 --> 00:29:37,270 +yes the price + +382 +00:29:37,270 --> 00:29:44,550 +when the first issue not now be careful yes when + +383 +00:29:44,550 --> 00:29:49,810 +the first issue they issuing a price and + +384 +00:29:49,810 --> 00:29:54,750 +it's one dollar for the common stocks generally it + +385 +00:29:54,750 --> 00:29:56,910 +is one dollar for the common stocks and ten dollar + +386 +00:29:56,910 --> 00:30:03,130 +for the preferred stocksالسعر السوقي مختلف من + +387 +00:30:03,130 --> 00:30:06,330 +السعر الحصري السعر السوقي هو السعر الحقيقي في + +388 +00:30:06,330 --> 00:30:10,870 +السوق وهناك اختلاف بين السعر الحصري والسعر السوقي + +389 +00:30:10,870 --> 00:30:15,730 +السعر السوقي أو السعر السوقي هو السعر في الواقع + +390 +00:30:15,730 --> 00:30:21,470 +التي تتحرك السوق في السوق المالي ولكن السعر الحصري + +391 +00:30:21,470 --> 00:30:37,390 +هو السعرعندما نقوم بإطلاق أربع سنة قبل قبل قبل + +392 +00:30:37,390 --> 00:30:41,730 +قبل قبل قبل قبل قبل قبل قبل قبل قبل قبل قبل قبل + +393 +00:30:41,730 --> 00:30:41,730 +قبل قبل قبل قبل قبل قبل قبل قبل قبل قبل قبل قبل + +394 +00:30:41,730 --> 00:30:41,730 +قبل قبل قبل قبل قبل قبل قبل قبل قبل قبل قبل قبل + +395 +00:30:41,730 --> 00:30:41,810 +قبل قبل قبل قبل قبل قبل قبل قبل قبل قبل قبل قبل + +396 +00:30:41,810 --> 00:30:42,090 +قبل قبل قبل قبل قبل قبل قبل قبل قبل قبل قبل قبل + +397 +00:30:42,090 --> 00:30:42,090 +قبل قبل قبل قبل قبل قبل قبل قبل قبل قبل قبل قبل + +398 +00:30:42,090 --> 00:30:42,090 +قبل قبل قبل قبل قبل قبل قبل قبل قبل قبل قبل قبل + +399 +00:30:42,090 --> 00:30:42,090 +قبل قبل قبل قبل قبل قبل قبل قبل قبل قبل قبل قبل + +400 +00:30:42,090 --> 00:30:47,190 +قبل قبل قبل قبل + +401 +00:30:47,190 --> 00:30:47,390 +ق + +402 +00:30:55,720 --> 00:31:01,380 +yes the same initial value the same لأ لأ be + +403 +00:31:01,380 --> 00:31:07,060 +careful here this one and this one the same but + +404 +00:31:07,060 --> 00:31:12,360 +when we say initial value for the accountants they + +405 +00:31:12,360 --> 00:31:18,760 +consider is the same for finance modern finance + +406 +00:31:18,760 --> 00:31:21,480 +they consider the initial value is something + +407 +00:31:21,480 --> 00:31:29,040 +differentالقيم الأولى هي القيم الحقيقية للشركة أو + +408 +00:31:29,040 --> 00:31:34,260 +الشركة التي لا أحد يعرف ما هي القيم الأولى هي + +409 +00:31:34,260 --> 00:31:39,400 +المتوقعة أو دعنا نقول القيم الحقيقية التي ليست + +410 +00:31:39,400 --> 00:31:44,440 +ملاحظة من المبادئ لا + +411 +00:31:44,440 --> 00:31:47,240 +أحد في المبادئ يعرف ما هي القيم الأولى أو ما هي + +412 +00:31:47,240 --> 00:31:51,660 +القيم الحقيقيةقيمة المشروع يجب أن نقوم ببعض + +413 +00:31:51,660 --> 00:31:57,820 +التخطيطات لكي نعرف قيمة البداية أو القيمة الحقيقية + +414 +00:31:57,820 --> 00:32:02,880 +هل تعرف شخص في هذا العالم يعرف قيمة الحقيقية؟ لا + +415 +00:32:02,880 --> 00:32:09,860 +لأن هذا القيمة البداية مثلًا + +416 +00:32:09,860 --> 00:32:12,560 +موقعه من المستخدمين و لأن لدينا الكثير من + +417 +00:32:12,560 --> 00:32:16,300 +المستخدمين حسنًا دعوني أعطيك مثلًا من القيمة + +418 +00:32:16,300 --> 00:32:16,540 +البداية + +419 +00:32:19,780 --> 00:32:27,940 +أو ما يسمونه قيمة عامة عامة عامة عامة عامة عامة + +420 +00:32:27,940 --> 00:32:35,140 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +421 +00:32:35,140 --> 00:32:37,200 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +422 +00:32:37,200 --> 00:32:42,000 +عامة عامة عامة عامة عامة عامة عامة + +423 +00:32:42,000 --> 00:32:47,420 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +424 +00:32:47,420 --> 00:32:47,420 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +425 +00:32:47,420 --> 00:32:47,420 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +426 +00:32:47,420 --> 00:32:50,850 +عامة عامة عامة عامة عامة عامة عامة عامة عهذا لـ + +427 +00:32:50,850 --> 00:32:59,410 +IBM هذا هو السعر اللي فلكتويت ل IBM هذا هو السعر + +428 +00:32:59,410 --> 00:33:04,450 +السوقي أين هو القيم الأولى أو القيم المستخدمة + +429 +00:33:04,450 --> 00:33:12,170 +القيم المستخدمة في مكان ما هنا هذا هو القيم الأولى + +430 +00:33:12,170 --> 00:33:20,040 +لهذا وهوقيمة السوق التي تتحرك حول قيمة الانترنت + +431 +00:33:20,040 --> 00:33:28,840 +لأن لا أحد يعرف، فالناس فقط تتحرك حولها، حسنًا؟ هي + +432 +00:33:28,840 --> 00:33:32,600 +مثلًا، القطار مخفي، و الناس تحاول أن تتوقع هذه + +433 +00:33:32,600 --> 00:33:33,900 +القطار، هم يذهبون على الأعلى، هم يذهبون على + +434 +00:33:33,900 --> 00:33:36,500 +الأسفل، هم يحاولون أن يحصلوا على هذه القطار، ولكن + +435 +00:33:36,500 --> 00:33:40,700 +لا أحد يحصل على هذه القطار. أحيانًا، هذا القيم + +436 +00:33:40,700 --> 00:33:46,690 +الانترنتهذا في IBM إذا كنت تنظر إلى شركة أخرى، + +437 +00:33:46,690 --> 00:33:53,490 +انظر إلى هنا قيمة الـ Intrinsic هي بعيدة + +438 +00:33:53,490 --> 00:33:59,110 +عن قيمة السوق، لذلك هذا السوق ليس مفيداً، هذا + +439 +00:33:59,110 --> 00:34:02,210 +السوق مفيداً عالياً، إذا كنت تنظر إلى هذا مرة أخرى + +440 +00:34:03,930 --> 00:34:08,170 +So the intrinsic value is very close to the .. the + +441 +00:34:08,170 --> 00:34:11,130 +more you are expected the .. the price, the more + +442 +00:34:11,130 --> 00:34:14,010 +you are close to the initial value. The more you + +443 +00:34:14,010 --> 00:34:16,150 +are knowledgeable about the business, the more you + +444 +00:34:16,150 --> 00:34:19,470 +are close to the intrinsic value. Not the bar + +445 +00:34:19,470 --> 00:34:23,250 +value, + +446 +00:34:23,330 --> 00:34:26,610 +the bar value is something .. is accounting. ال + +447 +00:34:26,610 --> 00:34:28,890 +bar value هي إيش بال accounting؟ accounting أول ما + +448 +00:34:28,890 --> 00:34:31,150 +تصدرش الأسهم هي بتصدر في bar value + +449 +00:34:34,750 --> 00:34:38,930 +نعم، فهنا هو قيمة الكتابة، تتكلم عن قيمة الكتابة، + +450 +00:34:38,930 --> 00:34:43,390 +فقيمة الكتابة هي قيمة الشركة في الوثيقة، في + +451 +00:34:43,390 --> 00:34:47,210 +الوثيقة الأساسية، إذا + +452 +00:34:47,210 --> 00:34:50,770 +كنا نقارن قيمة الكتابة مع .. مع ال .. مع الـ + +453 +00:34:50,770 --> 00:34:58,170 +Initial أو السعر السوقي، هذا قيمة الوثيقة و هذا + +454 +00:34:58,170 --> 00:35:01,550 +دعنا نقول قيمة السوق + +455 +00:35:03,100 --> 00:35:06,840 +القيمة البقية تدفع إلى مستخدمين غير معلومين غير + +456 +00:35:06,840 --> 00:35:13,120 +معلومين لأنك أول مرة تعرف أن هذه قيمة بقيمة عندما + +457 +00:35:13,120 --> 00:35:17,000 +نتعامل مع المستخدمين في الشبكات وفي السوق أكتر من + +458 +00:35:17,000 --> 00:35:22,420 +المستخدمين أعني مستخدمين غير معلومين هم ينظرون إلى + +459 +00:35:22,420 --> 00:35:29,630 +التعامل هم لا ينظرون إلى التعاملأنت ترى؟ لذلك + +460 +00:35:29,630 --> 00:35:32,810 +يتعاملون بالعمل باستخدام الـ balance sheet و + +461 +00:35:32,810 --> 00:35:36,830 +باستخدام الـ income statement كيف انا كمعرفة + +462 +00:35:36,830 --> 00:35:40,670 +اقتصادية لأعرف أن هؤلاء المستخدمين ينظروا إلى هذا + +463 +00:35:40,670 --> 00:35:44,430 +و هؤلاء المستخدمين ينظروا إلى هذا نحن نقوم + +464 +00:35:44,430 --> 00:35:47,770 +باستخدام قيمة الـ booking book value معظم + +465 +00:35:47,770 --> 00:35:54,630 +المستخدمين ينظروا إلى قيمة ال booking لأنهم لاعرفة + +466 +00:35:54,630 --> 00:35:58,170 +على قيم الأخرى من الأسعار على سبيل المثال، أنت أول + +467 +00:35:58,170 --> 00:36:02,390 +مرة تعرف عن قيم الأولى، أنت أول مرة تعرف عن قيم + +468 +00:36:02,390 --> 00:36:06,950 +الانتقال، أنت أول مرة تعرف أن هناك فرق بين قيم + +469 +00:36:06,950 --> 00:36:10,110 +السوق وقيم المشروع، إذا ذهبت إلى السوق، ترى، يا + +470 +00:36:10,110 --> 00:36:14,090 +عزيزي، انظر إلى قيم المشروع، أنت تخطأ نفسك، لأن + +471 +00:36:14,090 --> 00:36:19,870 +قيم المشروع هو قيم التعامل، وليس تفكير أفعال العمل + +472 +00:36:21,240 --> 00:36:26,900 +وبهذه الطريقة نقوم بتقاط إلى مدى أنك غير معروف أنك + +473 +00:36:26,900 --> 00:36:36,820 +لا تعرف عن الشركة بالمناسبة + +474 +00:36:36,820 --> 00:36:43,960 +هذا ليس المجال للتحدث ولكن المجال للتحدث ما أريدك + +475 +00:36:43,960 --> 00:36:50,150 +تعرفه هو أن السوق لديه قيمة كبيرةالقيمة المهمة على + +476 +00:36:50,150 --> 00:36:56,530 +مستوىك هي قيمة الاختصارولكن لماذا أقول هذا، فقط + +477 +00:36:56,530 --> 00:37:00,770 +لأرى إن في المستقبل، أخبرتني المدرسة الآن أن هناك + +478 +00:37:00,770 --> 00:37:06,070 +قيم أخرى، لذلك، كون حذرا، هناك قيم أخرى للسوق، ليس + +479 +00:37:06,070 --> 00:37:10,830 +فقط قيم الـ Bar القيم الـ Bar مقررة في الـ Balance + +480 +00:37:10,830 --> 00:37:17,210 +Sheet وليس تفكير تجارب الشبكة الحقيقية إذا أردت أن + +481 +00:37:17,210 --> 00:37:20,710 +تنظر إلى تجارب الشبكة الحقيقية، تنظر إلى قيم السوق + +482 +00:37:21,500 --> 00:37:23,880 +and then you estimate the initial value or + +483 +00:37:23,880 --> 00:37:26,580 +intrinsic value compare between them you see how + +484 +00:37:26,580 --> 00:37:28,500 +they are far away from the business and you are + +485 +00:37:28,500 --> 00:37:34,240 +decide where you go in the investments and this is + +486 +00:37:34,240 --> 00:37:37,800 +will cover in investments my student investments + +487 +00:37:38,290 --> 00:37:40,130 +وهي دراسات عملية عملية عملية عملية عملية عملية + +488 +00:37:40,130 --> 00:37:42,170 +عملية عملية عملية عملية عملية عملية عملية عملية + +489 +00:37:42,170 --> 00:37:47,550 +عملية عملية عملية عملية عملية عملية عملية عملية + +490 +00:37:47,550 --> 00:37:51,430 +عملية عملية عملية عملية عملية عملية عملية عملية + +491 +00:37:51,430 --> 00:37:51,730 +عملية عملية عملية عملية عملية عملية عملية عملية + +492 +00:37:51,730 --> 00:37:51,810 +عملية عملية عملية عملية عملية عملية عملية عملية + +493 +00:37:51,810 --> 00:37:51,810 +عملية عملية عملية عملية عملية عملية عملية عملية + +494 +00:37:51,810 --> 00:37:51,810 +عملية عملية عملية عملية عملية عملية عملية عملية + +495 +00:37:51,810 --> 00:37:51,810 +عملية عملية عملية عملية عملية عملية عملية عملية + +496 +00:37:51,810 --> 00:38:02,970 +عملية عملية + +497 +00:38:02,970 --> 00:38:04,770 +عوالمستخدمين المستخدمين المستخدمين المستخدمين + +498 +00:38:04,770 --> 00:38:06,370 +المستخدمين المستخدمين المستخدمين المستخدمين + +499 +00:38:06,370 --> 00:38:09,630 +المستخدمين المستخدمين المستخدمين المستخدمين + +500 +00:38:09,630 --> 00:38:10,650 +المستخدمين المستخدمين المستخدمين المستخدمين + +501 +00:38:10,650 --> 00:38:11,610 +المستخدمين المستخدمين المستخدمين المستخدمين + +502 +00:38:11,610 --> 00:38:12,930 +المستخدمين المستخدمين المستخدمين المستخدمين + +503 +00:38:12,930 --> 00:38:13,430 +المستخدمين المستخدمين المستخدمين المستخدمين + +504 +00:38:13,430 --> 00:38:13,530 +المستخدمين المستخدمين المستخدمين المستخدمين + +505 +00:38:13,530 --> 00:38:13,570 +المستخدمين المستخدمين المستخدمين المستخدمين + +506 +00:38:13,570 --> 00:38:15,570 +المستخدمين المستخدمين المستخدمين المستخدمين + +507 +00:38:15,570 --> 00:38:32,570 +المستخدمين المستخدمين المستخدمين المستخدمين المست + +508 +00:38:32,820 --> 00:38:38,900 +فقط قبل أن أترك هذه الاجتماعات سأعطيكم + +509 +00:38:38,900 --> 00:38:46,060 +مثال في محادثة كبيرة دعونا نرى الأول + +510 +00:38:46,060 --> 00:38:51,340 +مرة تسجل شركة شركات تسجل شركات بقيم أقصى على سبيل + +511 +00:38:51,340 --> 00:38:55,660 +المثال إذا كانوا يحتاجون 10 مليون دولار قيم أقصى + +512 +00:38:55,660 --> 00:39:01,220 +لكل شركة 1 دولار لذا يجب أن يسجلوا 10 مليون شركات + +513 +00:39:02,050 --> 00:39:09,490 +على قيمة البر واحد دولار لكل شئ لدينا 10 مليون شئ + +514 +00:39:09,490 --> 00:39:22,070 +دعونا نرى في 1990 هذا في 1990 حوالي 23 سنة لهذه + +515 +00:39:22,070 --> 00:39:29,030 +الشركة الآن نحن في 2013 نريد أن نطلق شركات أضافية + +516 +00:39:32,140 --> 00:39:37,160 +نعود إلى قيمة الواحدة قيمة الواحدة دولار هذا حسنًا + +517 +00:39:37,160 --> 00:39:42,880 +ولكن المشكلة هي أن سعر هذا الشركة ليس واحد دولار + +518 +00:39:42,880 --> 00:39:52,360 +ربما في السوق الآن السعر هو 76 دولار لقيمة السوق + +519 +00:39:52,360 --> 00:39:57,840 +لقيمة السوق فقيمة السوق 76 دولار هذا غير صحيح + +520 +00:39:57,840 --> 00:40:03,240 +للمستخدمين القديمينto pay or to let's say to sell + +521 +00:40:03,240 --> 00:40:07,900 +new stocks I mean additional stocks be careful the + +522 +00:40:07,900 --> 00:40:12,680 +company wanted to to issue additional stocks it is + +523 +00:40:12,680 --> 00:40:16,740 +unfair that new comers new investors to buy one + +524 +00:40:16,740 --> 00:40:21,020 +dollar if you pay one dollar it means me and you + +525 +00:40:21,020 --> 00:40:28,460 +the sameالسعر 76 دولار في السوق لذلك ما يفعله + +526 +00:40:28,460 --> 00:40:33,580 +المستخدم انت تدفع 76 دولار لكي تشتري هذا 1 دولار + +527 +00:40:33,580 --> 00:40:35,100 +لكي تشتري هذا 1 دولار لكي تشتري هذا 1 دولار لكي + +528 +00:40:35,100 --> 00:40:35,560 +تشتري هذا 1 دولار لكي تشتري هذا 1 دولار لكي تشتري + +529 +00:40:35,560 --> 00:40:37,800 +هذا 1 دولار لكي تشتري هذا 1 دولار لكي تشتري هذا 1 + +530 +00:40:37,800 --> 00:40:39,040 +دولار لكي تشتري هذا 1 دولار لكي تشتري هذا 1 دولار + +531 +00:40:39,040 --> 00:40:42,420 +لكي تشتري هذا 1 دولار لكي تشتري هذا 1 دولار لكي + +532 +00:40:42,420 --> 00:40:45,420 +تشتري هذا 1 دولار لكي تشتري هذا 1 دولار لكي تشتري + +533 +00:40:45,420 --> 00:40:50,340 +هذا 1 دولار لكي تشتري هذا75 دولار. لذلك في النهاية + +534 +00:40:50,340 --> 00:40:56,420 +تدفع 76 دولار. لذلك 75 دولار هي تجارب للمستخدمين + +535 +00:40:56,420 --> 00:41:02,920 +القديمين. نعم التجارب لأنهم بالفعل أخذوا خطر في + +536 +00:41:02,920 --> 00:41:08,760 +1990. لذلك 75 دولار مثلًا يعطيهم فرصة للتطور. + +537 +00:41:11,270 --> 00:41:15,390 +Okay, so this is the idea of paid in capital is + +538 +00:41:15,390 --> 00:41:18,230 +the additional amount, see the additional amount, + +539 +00:41:18,310 --> 00:41:25,530 +75$, the firm raised when it sold the shares Okay, + +540 +00:41:27,730 --> 00:41:34,750 +what wrong?على سبيل المثال، قيمة شركة DLK هي 2 + +541 +00:41:34,750 --> 00:41:39,370 +دولار وشركة DLK لديها 30 مليون شرح ممتازة بحيث + +542 +00:41:39,370 --> 00:41:43,530 +قيمة شركة DLK لديها 60 مليون شرح ممتازة إذا كانت + +543 +00:41:43,530 --> 00:41:44,990 +الشركات تم إطلاق 240 مليون و 180 مليون شرح ممتازة + +544 +00:41:44,990 --> 00:41:47,590 +بحيث كانت الشركة تم إطلاق 240 مليون شرح ممتازة + +545 +00:41:47,590 --> 00:41:48,730 +بحيث كانت الشركة تم إطلاق 140 مليون شرح ممتازة + +546 +00:41:48,730 --> 00:41:50,830 +بحيث كانت الشركة تم إطلاق 140 مليون شرح ممتازة + +547 +00:41:50,830 --> 00:41:52,170 +بحيث كانت الشركة تم إطلاق 140 مليون شرح ممتازة + +548 +00:41:52,170 --> 00:41:57,800 +بحيث كانت الشركة تم إطلاق 140 مليونوإن شاء الله في + +549 +00:41:57,800 --> 00:42:01,060 +المقابلة القادمة سنكمل ونتحدث عن المثال، فقط + +550 +00:42:01,060 --> 00:42:07,420 +أذكرني أن أتحدث عن هذا المثال لإختلاف بين قيمة الـ + +551 +00:42:07,420 --> 00:42:08,520 +bar و قيمة البيت + diff --git a/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/pVpkbdHrxJ4_postprocess.srt b/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/pVpkbdHrxJ4_postprocess.srt new file mode 100644 index 0000000000000000000000000000000000000000..e3f25d2283d0f12a25fdd6f6ccf567c6660c953f --- /dev/null +++ b/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/pVpkbdHrxJ4_postprocess.srt @@ -0,0 +1,1660 @@ +1 +00:00:21,110 --> 00:00:26,970 +بسم الله الرحمن الرحيم in chapter seven we talk + +2 +00:00:26,970 --> 00:00:33,250 +about risk and return okay in this chapter we will + +3 +00:00:33,250 --> 00:00:40,480 +talk about risk and return but by ..في نقطة نظرية + +4 +00:00:40,480 --> 00:00:46,840 +كابتنال ماركت ما يقول نظرية كابتنال ماركت عن + +5 +00:00:46,840 --> 00:00:54,940 +الهجوم والعودة هذه هي فكرة هذا الحلقه موجودة + +6 +00:00:54,940 --> 00:01:01,000 +في هذه الصفحه التعليقات المستخدمة في هذا الحلقه + +7 +00:01:01,000 --> 00:01:05,460 +وهي الـ key terms سنتحدث عن الهجوم والعودة والهجوم + +8 +00:01:05,460 --> 00:01:05,820 +الهجوم + +9 +00:01:09,890 --> 00:01:15,810 +ثم نتكلم عن ماذا يعني البرتفاليو ثم نتكلم عن + +10 +00:01:15,810 --> 00:01:19,630 +الأشياء المرتبطة بالسيستماتيك ريسك وماركت + +11 +00:01:19,630 --> 00:01:25,390 +البرتفاليو ثم نتكلم عن سيكورتي ماركت لاين وKABAM + +12 +00:01:25,390 --> 00:01:34,970 +KABAM تعني كابتل أسس مودي قيمةمع ذلك مرة أخرى CAPM + +13 +00:01:34,970 --> 00:01:38,230 +هو Model Capital Asset Pricing هذا الموديل تم + +14 +00:01:38,230 --> 00:01:46,150 +تطبيقه من شارب وهو + +15 +00:01:46,150 --> 00:01:51,650 +فائتش نوبل برايس وفي + +16 +00:01:51,650 --> 00:01:57,410 +نهاية هذا الحلقه سنتحدث عن كلمات أساسية لهذا + +17 +00:01:57,410 --> 00:02:02,090 +الحلقهالهدف الرئيسي للتعرف هي تخطيط مراتة الترجمه + +18 +00:02:02,090 --> 00:02:06,110 +المتوقعة للترجمه للترجمه + +19 +00:02:06,110 --> 00:02:11,210 +للترجمه للترجمه للترجمه للترجمه للترجمه للترجمه + +20 +00:02:11,210 --> 00:02:11,730 +للترجمه للترجمه للترجمه للترجمه للترجمه للترجمه + +21 +00:02:11,730 --> 00:02:11,830 +للترجمه للترجمه للترجمه للترجمه للترجمه للترجمه + +22 +00:02:11,830 --> 00:02:11,870 +للترجمه للترجمه للترجمه للترجمه للترجمه للترجمه + +23 +00:02:11,870 --> 00:02:18,530 +للترجمه للترجمه للترجمه للترجمه للترجمه + +24 +00:02:18,530 --> 00:02:28,220 +للترجمه للترجعن طريق فهم المهارات التدريسية مصطلح + +25 +00:02:28,220 --> 00:02:36,540 +portfolio مصطلح portfolio مصطلح مصطلح مصطلح مصطلح + +26 +00:02:36,540 --> 00:02:38,600 +مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح + +27 +00:02:38,600 --> 00:02:38,740 +مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح + +28 +00:02:38,740 --> 00:02:41,600 +مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح مصطلح + +29 +00:02:41,600 --> 00:02:45,360 +مصطلح + +30 +00:02:45,360 --> 00:02:49,740 +مصطلح مصطلح + +31 +00:02:49,740 --> 00:02:55,890 +ميمكنك انتقال هذا الـ 1000 دولار في واحدة من + +32 +00:02:55,890 --> 00:03:02,130 +الانتقالات الوحيدة يمكنك انتقالها في العديد من + +33 +00:03:02,130 --> 00:03:08,750 +الانتقالات المختلفة 1,2,3,4 لذلك البرتفاليو يحتوي + +34 +00:03:08,750 --> 00:03:14,410 +على الـ 1,2,3,4 المهمة الرئيسية لهذا البرتفاليو هو + +35 +00:03:14,410 --> 00:03:19,470 +تقليل الرخصة وإعادة إعادة عودتها البرتفاليو هو + +36 +00:03:19,470 --> 00:03:20,910 +مجموعة أشخاص مختلفة + +37 +00:03:24,880 --> 00:03:32,520 +ولكن في هذا الانتجار نحن مواجهين ضرر واحد من + +38 +00:03:32,520 --> 00:03:36,940 +الانتجارات المحددة ولكننا نستطيع أن نتخلص من فرصة + +39 +00:03:36,940 --> 00:03:42,100 +ضرر واحدة من الانتجارات باستخدام الانتجارات + +40 +00:03:42,100 --> 00:03:47,900 +التجارية هذا هو المعنى من الانتجارات التجارية + +41 +00:03:47,900 --> 00:03:50,940 +وسنقوم باستخدام الانتجارات التجارية التجارية + +42 +00:03:50,940 --> 00:03:55,480 +التجاريةReturns using Capital Asset Pricing Model + +43 +00:03:55,480 --> 00:04:00,680 +The Capital Asset Pricing Model R is equal to risk + +44 +00:04:00,680 --> 00:04:06,460 +-free plus beta RM minus RF So we'll talk in + +45 +00:04:06,460 --> 00:04:11,860 +details about this model So the RI is the required + +46 +00:04:11,860 --> 00:04:15,660 +rate of return of I is equal to risk-free plus + +47 +00:04:15,660 --> 00:04:22,740 +beta Beta is the systematic risk measuresوقت خطر + +48 +00:04:22,740 --> 00:04:27,380 +أو عادة السوق وخلاص من الخطر نحن سنتحدث عن هذا + +49 +00:04:27,380 --> 00:04:33,100 +الموضوع المصطلحات تتعامل مع هذا الموضوع المصطلحات + +50 +00:04:33,100 --> 00:04:37,140 +تتعامل مع خطر + +51 +00:04:37,140 --> 00:04:42,400 +و عادة السوق في هذا الحلقه هناك خطر و عادة السوق + +52 +00:04:42,400 --> 00:04:46,000 +نستخدم خطر و عادة السوق لنقوم باستخدام بورتفاليو + +53 +00:04:48,210 --> 00:04:53,370 +في الحلقات السابقة نتحدث عن الانتجارات الوحيدة RI، + +54 +00:04:53,370 --> 00:04:57,730 +ولكن اليوم سنتحدث عن ال RP، الوصول إلى البرتفاليو + +55 +00:04:57,730 --> 00:05:04,710 +وكيف يتأثر الوصول إلى البرتفاليو برغم أهداف السوق + +56 +00:05:07,550 --> 00:05:09,670 +والأفكار المفيدة لـ Portfolio Diversification على + +57 +00:05:09,670 --> 00:05:11,510 +الرغم من الرغم من الرغم من الرغم من الرغم من الرغم + +58 +00:05:11,510 --> 00:05:11,710 +من الرغم من الرغم من الرغم من الرغم من الرغم من + +59 +00:05:11,710 --> 00:05:13,370 +الرغم من الرغم من الرغم من الرغم من الرغم من الرغم + +60 +00:05:13,370 --> 00:05:13,630 +من الرغم من الرغم من الرغم من الرغم من الرغم من + +61 +00:05:13,630 --> 00:05:15,130 +الرغم من الرغم من الرغم من الرغم من الرغم من الرغم + +62 +00:05:15,130 --> 00:05:15,170 +من الرغم من الرغم من الرغم من الرغم من الرغم من + +63 +00:05:15,170 --> 00:05:17,890 +الرغم من الرغم من الرغم من الرغم من الرغم من الرغم + +64 +00:05:17,890 --> 00:05:18,170 +من الرغم من الرغم من الرغم من الرغم من الرغم من + +65 +00:05:18,170 --> 00:05:26,850 +الرغم من الرغم من الرغم من الرغم من الرغم من الرغم + +66 +00:05:26,850 --> 00:05:34,770 +من الرغم من + +67 +00:05:42,880 --> 00:05:49,420 +دعنا نعتبر هذا المثال مثالًا هنا إذا قمنا + +68 +00:05:49,420 --> 00:05:58,280 +بالاستثمار في A وB أساتذين أو أساتذين خطرين، هذا + +69 +00:05:58,280 --> 00:06:05,020 +هو الميزانية، لذلك لدينا A وB إذا كنا نريد أن + +70 +00:06:05,020 --> 00:06:10,200 +نتخطى الخطر، عادة B، هذا يعني عادة B عادة + +71 +00:06:10,200 --> 00:06:11,780 +الميزانية، + +72 +00:06:14,050 --> 00:06:20,750 +سأرى ما هي المقادة لـ A وما هي المقادة لـ B، ففي + +73 +00:06:20,750 --> 00:06:27,070 +هذه اللحظة ما هي الطريقات الطريقة لـ A وطريقة لـ B + +74 +00:06:27,070 --> 00:06:30,590 +كم نقوم بالاستثمار في A وكم نقوم بالاستثمار في B؟ + +75 +00:06:30,590 --> 00:06:38,130 +إذا قلنا إن هذا 1000$، البرتفالي عام و 30% في A + +76 +00:06:38,130 --> 00:06:39,910 +و70% في B + +77 +00:06:43,630 --> 00:06:49,650 +وهذا يعني أن عادة البرتفالي هي الطريقة من A مرتفعة + +78 +00:06:49,650 --> 00:07:00,730 +من A مرتفعة من B مرتفعة من B مرتفعة من B مرتفعة من + +79 +00:07:00,730 --> 00:07:01,110 +B مرتفعة من B مرتفعة من B مرتفعة من B مرتفعة من B + +80 +00:07:01,110 --> 00:07:05,710 +مرتفعة من B مرتفعة من A مرتفعة من A مرتفعة من A + +81 +00:07:05,710 --> 00:07:07,830 +مرتفعة من A مرتفعة من A مرتفعة من A مرتفعة من A + +82 +00:07:07,830 --> 00:07:10,070 +مرتفعة من A مرتفعة من A مرتفعة من A مرتفعة من A + +83 +00:07:10,070 --> 00:07:23,620 +مرتفعةإذا إعادة A هي 12% وإعادة P هي 20%، فالإعادة + +84 +00:07:23,620 --> 00:07:30,840 +P هي 30%×12 + +85 +00:07:30,840 --> 00:07:38,260 +% 70%×20 + +86 +00:07:38,260 --> 00:07:52,100 +%والنتيجة هي 17.6% لذلك + +87 +00:07:52,100 --> 00:08:01,580 +إجابة البرتفاليو B هي عدد ميزة عدد عدد عدد عدد عدد + +88 +00:08:01,580 --> 00:08:01,900 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +89 +00:08:01,900 --> 00:08:02,940 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +90 +00:08:02,940 --> 00:08:03,300 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +91 +00:08:03,300 --> 00:08:05,740 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +92 +00:08:05,740 --> 00:08:10,060 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +93 +00:08:10,060 --> 00:08:10,500 +ع + +94 +00:08:16,280 --> 00:08:22,080 +W1R1 W2R2 WNRN + +95 +00:08:22,080 --> 00:08:30,160 +So this is the return of portfolio the + +96 +00:08:30,160 --> 00:08:33,820 +question is is this work for the sigma for the + +97 +00:08:33,820 --> 00:08:41,240 +risk so if we want to calculate sigma bSigma for + +98 +00:08:41,240 --> 00:08:47,160 +the portfolio do you think w one sigma one plus w + +99 +00:08:47,160 --> 00:08:54,180 +two sigma two plus wn sigma n do you think this is + +100 +00:08:54,180 --> 00:08:59,840 +right yes or no so + +101 +00:08:59,840 --> 00:09:03,760 +when we calculate the return of portfolio we use + +102 +00:09:03,760 --> 00:09:08,580 +this equation does this same thing is right + +103 +00:09:11,290 --> 00:09:16,730 +لأ لأ لأ لأ لأ لأ + +104 +00:09:16,730 --> 00:09:16,890 +لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ + +105 +00:09:16,890 --> 00:09:20,090 +لأ لأ لأ لأ لأ لأ + +106 +00:09:20,090 --> 00:09:20,610 +لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ + +107 +00:09:20,610 --> 00:09:22,110 +لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ + +108 +00:09:22,110 --> 00:09:23,450 +لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ + +109 +00:09:23,450 --> 00:09:29,690 +لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ لأ + +110 +00:09:29,690 --> 00:09:40,190 +لأ + +111 +00:09:41,440 --> 00:09:49,120 +ولكن سيجما بي هو تأثير عن التعاون بين عادة a و + +112 +00:09:49,120 --> 00:09:53,260 +عادة b فالرسك + +113 +00:09:53,260 --> 00:10:01,300 +هو تأثير عن روه بمعاملة روه روه هي التعاون بين + +114 +00:10:01,300 --> 00:10:08,230 +عادة a و عادة bولكن هذا ليس صحيح في حالة الترجمه + +115 +00:10:08,230 --> 00:10:14,650 +لذلك الترجمه ليس مؤثر على التقريب بين الترجمه لـ A + +116 +00:10:14,650 --> 00:10:22,410 +و الترجمه لـ B لذلك، لكي أتخيل هذا لكي أتخيل سيجما + +117 +00:10:22,410 --> 00:10:31,810 +بي سيجما بي هو ايضا قصة + +118 +00:10:33,150 --> 00:10:41,250 +و1 squared sigma 1 squared plus w2 squared sigma 2 + +119 +00:10:41,250 --> 00:10:56,530 +squared plus 2 w1 w2 rho 1 2 sigma 1 sigma 2 okay + +120 +00:10:56,530 --> 00:10:58,930 +this is very simple + +121 +00:11:02,220 --> 00:11:07,120 +هذا فقط نعتبر أننا لدينا اتفاقين + +122 +00:11:07,120 --> 00:11:14,520 +اثنين إذا كان لدينا اتفاقين ثلاثة حسنا؟ + +123 +00:11:14,520 --> 00:11:17,500 +أنا لا أريد أن أدخل في التفاصيل عن هذا أقصد أن + +124 +00:11:17,500 --> 00:11:23,800 +يكون هناك ثلاثة أو أربع أمنين لأن في الدراسة + +125 +00:11:23,800 --> 00:11:28,660 +الاتفاقية سنتحدث في التفاصيل عن التخطيط لـ Sigma B + +126 +00:11:28,660 --> 00:11:38,670 +أو البرتفاضات Sigma Bهذه هي المثالة للعودة + +127 +00:11:38,670 --> 00:11:42,710 +والإشارة دعونا ندخل في التفاصيل عن هذا الموضوع فقط + +128 +00:11:42,710 --> 00:11:47,730 +أقدم لك تفاصيل Portfolio Returns و Portfolio Risk + +129 +00:11:47,730 --> 00:11:52,070 +بمعالجة + +130 +00:11:52,070 --> 00:11:56,470 +الهواتف المناسبة يمكننا أن ندفع رحلة Portfolioولم + +131 +00:11:56,470 --> 00:11:58,830 +يتخلص من تخلص المستخدم المتوقع من المستخدم، هذا هو + +132 +00:11:58,830 --> 00:12:03,490 +الاسبب لتصميم المستخدم المتوقع المتوقع المتوقع + +133 +00:12:03,490 --> 00:12:06,390 +المتوقع المتوقع المتوقع المتوقع المتوقع المتوقع + +134 +00:12:06,390 --> 00:12:06,810 +المتوقع المتوقع المتوقع المتوقع المتوقع المتوقع + +135 +00:12:06,810 --> 00:12:07,230 +المتوقع المتوقع المتوقع المتوقع المتوقع المتوقع + +136 +00:12:07,230 --> 00:12:09,930 +المتوقع المتوقع المتوقع المتوقع المتوقع المتوقع + +137 +00:12:09,930 --> 00:12:10,330 +المتوقع المتوقع المتوقع المتوقع المتوقع المتوقع + +138 +00:12:10,330 --> 00:12:12,470 +المتوقع المتوقع المتوقع المتوقع المتوقع المتوقع + +139 +00:12:12,470 --> 00:12:13,790 +المتوقع المتوقع المتوقع المتوقع المتوقع المتوقع + +140 +00:12:23,380 --> 00:12:28,720 +ما يعنيه؟ مايعنيه لا شيء لذلك، لماذا البرتفاليو + +141 +00:12:28,720 --> 00:12:35,820 +مستحيل؟ لأنه يزيد عدد العودة ويقل عدد الفرصة عدد + +142 +00:12:35,820 --> 00:12:38,640 +البرتفاليو يعيد عدد عدد عدد فرصة البرتفاليو مرة + +143 +00:12:38,640 --> 00:12:42,240 +أخرى، مع تدفع مناسبة نستطيع أن ندفع عدد فرصة + +144 +00:12:42,240 --> 00:12:44,980 +البرتفاليو بدون أن ندفع عدد عدد عدد فرصة + +145 +00:12:44,980 --> 00:12:49,600 +البرتفاليو المتوقع لذلك، هذا مهم جدًا. يمكن أن يتم + +146 +00:12:49,600 --> 00:12:55,420 +إزالة بعض الفرصةبالنسبة للخطط غير مستسامية، نستطيع + +147 +00:12:55,420 --> 00:13:01,540 +إزالة أو إزالة طريقًا تأثير الخطط غير مستسامية، + +148 +00:13:01,540 --> 00:13:04,760 +وسأتكلم عن ما يعنيه خطط غير مستسامية، بعض الخطط + +149 +00:13:04,760 --> 00:13:10,260 +يمكن تخلصها من وجه التدوير، والخطط التي يمكن + +150 +00:13:10,260 --> 00:13:13,900 +تخلصها ليست بالتأكيد موجودة في مجتمع الأسعار + +151 +00:13:17,160 --> 00:13:23,080 +هذا الخطر اللي انامه لا يوجد تجارب لهذا الخطر + +152 +00:13:24,650 --> 00:13:27,170 +لتخطيط عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +153 +00:13:27,170 --> 00:13:32,730 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +154 +00:13:32,730 --> 00:13:34,950 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +155 +00:13:34,950 --> 00:13:35,170 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +156 +00:13:35,170 --> 00:13:53,570 +عدد عد + +157 +00:13:54,740 --> 00:13:59,460 +with an expected rate of return minus 32 so the R + +158 +00:13:59,460 --> 00:14:05,660 +so if we say this is the way this is for C and + +159 +00:14:05,660 --> 00:14:12,720 +this is R the R is minus 32 percent for C and + +160 +00:14:12,720 --> 00:14:17,000 +75 percent of your money is in stock Apple so this + +161 +00:14:17,000 --> 00:14:19,160 +is in Apple you know Apple + +162 +00:14:24,070 --> 00:14:29,570 +Okay, so in apple with an expected rate of return + +163 +00:14:29,570 --> 00:14:32,290 +one hundred twenty percent. So we have seventy + +164 +00:14:32,290 --> 00:14:35,810 +five percent weight and What will be the expected + +165 +00:14:35,810 --> 00:14:39,490 +rate of return on you on this portfolio? So the + +166 +00:14:39,490 --> 00:14:42,430 +rates of this portfolio is equal to the weight of + +167 +00:14:42,430 --> 00:14:48,550 +C Times the R of C plus the weight of Apple Times + +168 +00:14:48,550 --> 00:15:01,980 +the R of Apple OkaySo 25% times minus 32% plus 75% + +169 +00:15:01,980 --> 00:15:11,320 +times 120% 82% look at here if we invest only in + +170 +00:15:11,320 --> 00:15:19,320 +the city bank we will lose minus 32% and if we + +171 +00:15:19,320 --> 00:15:25,400 +invest only in the appleسنحصل على 120% ولكن + +172 +00:15:25,400 --> 00:15:30,400 +الترتيب في الـ investment in two هو 82% هذا يعني + +173 +00:15:30,400 --> 00:15:37,360 +أن ترتيب أبل تغيّر فرصة فرصة فرصة فرصة فرصة فرصة + +174 +00:15:37,360 --> 00:15:43,060 +فرصة city bank في كلمة + +175 +00:15:43,060 --> 00:15:50,200 +أخرى، البرتفالي يتخلص من إدارة ترتيب أبل + +176 +00:15:52,910 --> 00:15:59,010 +Okay, so this is the formula then W1 times the + +177 +00:15:59,010 --> 00:16:03,990 +expected return of 1 W2 times Wn times the + +178 +00:16:03,990 --> 00:16:07,550 +expected rate of return of 2 Take this example + +179 +00:16:07,550 --> 00:16:15,490 +here Calculating + +180 +00:16:15,490 --> 00:16:16,950 +portfolio expected rate of return + +181 +00:16:19,740 --> 00:16:26,480 +بيني سمسون لديها عمل فرص عام و هي تفكير كيف تستخدم + +182 +00:16:26,480 --> 00:16:33,640 +حصتها والدها تفكير انها لا تستخدم اكثر من 25% من + +183 +00:16:33,640 --> 00:16:42,500 +حصتها في عمليها وهو Emerson Electric ف25% من المال + +184 +00:16:42,500 --> 00:16:56,090 +هي 25% في EmersonSo we'll invest in Emerson So + +185 +00:16:56,090 --> 00:16:59,370 +here Emerson the weight is 25% + +186 +00:17:04,260 --> 00:17:07,100 +So she is considering investing the remaining or + +187 +00:17:07,100 --> 00:17:11,900 +the rest 75% in combination of a risk-free + +188 +00:17:11,900 --> 00:17:14,220 +investment in the United States treasury bills + +189 +00:17:14,220 --> 00:17:21,660 +currently paying 4% So the 75% with the .. فى + +190 +00:17:21,660 --> 00:17:25,200 +combination .. فى combination of .. risk-free + +191 +00:17:25,200 --> 00:17:29,830 +investmentOkay a combination of risk-free + +192 +00:17:29,830 --> 00:17:31,610 +investment in United States treasury bills + +193 +00:17:31,610 --> 00:17:37,330 +currently paying 4% So we have 4% are .. So how + +194 +00:17:37,330 --> 00:17:42,290 +much is the return of Emerson? 75% a combination + +195 +00:17:42,290 --> 00:17:45,890 +of risk-free investment in United States treasury + +196 +00:17:45,890 --> 00:17:50,910 +bills currently paying 4% So this is 4% for the + +197 +00:17:50,910 --> 00:17:51,570 +treasury bills + +198 +00:17:54,450 --> 00:17:57,770 +and Starbucks common stocks you know Starbucks + +199 +00:17:57,770 --> 00:18:07,010 +okay Starbucks two months ago they launch a new + +200 +00:18:07,010 --> 00:18:12,950 +services tea shop the tea shop we know coffee shop + +201 +00:18:12,950 --> 00:18:18,270 +but they Starbucks launch a new product or new + +202 +00:18:18,270 --> 00:18:23,700 +services tea shopانستدفت كافي شاب او in addition + +203 +00:18:23,700 --> 00:18:26,960 +to the coffee shop in this shop they only serving + +204 +00:18:26,960 --> 00:18:31,860 +the tea so people they they want tea just go to + +205 +00:18:31,860 --> 00:18:35,980 +the Starbucks in the branch of tea shop and they + +206 +00:18:35,980 --> 00:18:40,160 +they have hundreds of different types of tea with + +207 +00:18:40,160 --> 00:18:47,380 +different taste people love the some people love + +208 +00:18:47,380 --> 00:18:50,180 +the tea shop so this is important for Starbucks + +209 +00:18:51,780 --> 00:18:57,160 +الشركات الرئيسية لل .. الشركات الرئيسية لل + +210 +00:18:57,160 --> 00:19:04,020 +Starbucks كوستا .. كوستا ليست كوستا .. كوستا هي + +211 +00:19:04,020 --> 00:19:07,920 +الشركات الرئيسية لل Starbucks على أية حال ، أبو + +212 +00:19:07,920 --> 00:19:11,660 +فيني قد انتقل إلى مجتمع السوق لعامين ومن المفروض + +213 +00:19:11,660 --> 00:19:19,080 +أن فيني قد تتوقع 9% في أمريسون 9% في أمريسون ، فرق + +214 +00:19:19,080 --> 00:19:28,210 +9% في أمريسونوهو قبل عامين و 9% من شرائه أمريكا و + +215 +00:19:28,210 --> 00:19:36,290 +12% من شركة ستاربوكس و ستاربوكس 12 + +216 +00:19:36,290 --> 00:19:43,250 +% من شركة ستاربوكس و بينهم قرروا أن يضعوا 25% في + +217 +00:19:43,250 --> 00:19:47,590 +أمريكا و 25% في ستاربوكس + +218 +00:19:51,280 --> 00:19:56,120 +والباقية يبقى 50% في حملة الحملة ترى أنك يجب أن + +219 +00:19:56,120 --> 00:20:00,380 +تكون لديك طاولة مثل هذه وعندما تسكين أو تسكين + +220 +00:20:00,380 --> 00:20:09,480 +فالشخص يحاول أن يضع بطريقة صحيحة لا تتحرك إلى + +221 +00:20:09,480 --> 00:20:12,900 +النقطة التالية إلا إذا فانت فاهم ماهي الشخص لهذا + +222 +00:20:12,900 --> 00:20:13,220 +الموضوع + +223 +00:20:16,700 --> 00:20:22,620 +عن طريق تحقيق المستخدم، تحقيق المستخدم، تحقيق + +224 +00:20:22,620 --> 00:20:23,200 +المستخدم، تحقيق المستخدم، تحقيق المستخدم، تحقيق + +225 +00:20:23,200 --> 00:20:23,360 +المستخدم، تحقيق المستخدم، تحقيق المستخدم، تحقيق + +226 +00:20:23,360 --> 00:20:27,220 +المستخدم، تحقيق المستخدم، تحقيق المستخدم، تحقيق + +227 +00:20:27,220 --> 00:20:30,120 +المستخدم، تحقيق المستخدم، تحقيق المستخدم، تحقيق + +228 +00:20:30,120 --> 00:20:35,560 +المستخدم، تحقيق المستخدم، تحقيق المستخدم، تحقيق + +229 +00:20:35,560 --> 00:20:41,280 +المستخدم، تحقيق المستخدم، تحقيق المستخدم، تحقيق + +230 +00:20:41,280 --> 00:20:56,990 +المستخدم، تحقيهذا هو إرجاع هذا البرتفالي فإن + +231 +00:20:56,990 --> 00:21:05,330 +إرجاع البرتفالي هو ثم 7% إذا + +232 +00:21:05,330 --> 00:21:12,090 +نعود و نتعامل بالإرجاع سنرى أن ستاربوكس ترغب في + +233 +00:21:12,090 --> 00:21:17,120 +أعلى عدد إرجاعلماذا؟ لأنه موضوع للرغم من السيئة + +234 +00:21:17,120 --> 00:21:21,200 +الأعلى، بيانات المحافظة اقترحوا الرغم من السيئة + +235 +00:21:21,200 --> 00:21:25,900 +الأسفة، لهذا السبب لديها قيمة إعادة أسفة أعلى + +236 +00:21:25,900 --> 00:21:32,240 +أبرسون إلكتريك مستقل، ولكن أعتقد أن ستاربوكس + +237 +00:21:32,240 --> 00:21:37,960 +وغيرهاالشركات المرتبطة هي تقريبا أقل حرارة + +238 +00:21:37,960 --> 00:21:44,360 +بالمقارنة مع اخر حرارات مثل عملية عملية عملية + +239 +00:21:44,360 --> 00:21:44,420 +عملية عملية عملية عملية عملية عملية عملية عملية + +240 +00:21:44,420 --> 00:21:44,760 +عملية عملية عملية عملية عملية عملية عملية عملية + +241 +00:21:44,760 --> 00:21:45,940 +عملية عملية عملية عملية عملية عملية عملية عملية + +242 +00:21:45,940 --> 00:21:46,140 +عملية عملية عملية عملية عملية عملية عملية عملية + +243 +00:21:46,140 --> 00:21:46,940 +عملية عملية عملية عملية عملية عملية عملية عملية + +244 +00:21:46,940 --> 00:21:52,300 +عملية عملية + +245 +00:21:52,300 --> 00:22:02,560 +عملية + +246 +00:22:02,560 --> 00:22:12,530 +عفي السوق العالمي لتحدث عن T-Shirt فهذه + +247 +00:22:12,530 --> 00:22:21,110 +هي عادة من هذا الوصف وهذه + +248 +00:22:21,110 --> 00:22:27,350 +هي الاناليزة هذا مثال أخر هنا إذا أردت أن تنظر إلى + +249 +00:22:27,350 --> 00:22:31,850 +check + +250 +00:22:31,850 --> 00:22:38,450 +point 8.1العادة المتوقعة للعودة لـ Portfolio + +251 +00:22:38,450 --> 00:22:44,730 +كومبوز 50% في تجارب البيلز 25% في Emerson Electric + +252 +00:22:44,730 --> 00:22:51,950 +والتقليد 25% تاربوكس السوق 7% تلاقوا أننا رفعنا + +253 +00:22:51,950 --> 00:22:55,470 +لعدة التجارب البيلز كعادة المتوقعة للعودة هذه + +254 +00:22:55,470 --> 00:22:59,890 +تقنية صحيحة لأن هذه العودة تعتمد على أنها غير + +255 +00:22:59,890 --> 00:23:04,460 +خطريةمثلًا، إذا قمت بتحقيق شريحة مالية مالية مالية + +256 +00:23:04,460 --> 00:23:04,580 +مالية مالية مالية مالية مالية مالية مالية مالية + +257 +00:23:04,580 --> 00:23:04,640 +مالية مالية مالية مالية مالية مالية مالية مالية + +258 +00:23:04,640 --> 00:23:08,300 +مالية مالية مالية مالية مالية مالية مالية + +259 +00:23:13,810 --> 00:23:19,470 +هذا فقط نتيجة ممكنة هذا ليس حاليًا لأي إستخدام أخر + +260 +00:23:19,470 --> 00:23:23,430 +يمكننا أن نتخلص من قيمة المستقبل للميزانية في نفس + +261 +00:23:23,430 --> 00:23:27,830 +الطريقة باستخدام تأثير الميزانية في الميزانية + +262 +00:23:27,830 --> 00:23:32,370 +باستخدام تأثير الميزانية في الميزانية في الميزانية + +263 +00:23:32,370 --> 00:23:36,190 +باستخدام تأثير الميزانية + +264 +00:23:36,190 --> 00:23:36,570 +في الميزانية في الميزانية في الميزانية في + +265 +00:23:36,570 --> 00:23:36,730 +الميزانية في الميزانية في الميزانية في الميزانية + +266 +00:23:36,730 --> 00:23:37,010 +في الميزانية في الميزانية في الميزانية في + +267 +00:23:37,010 --> 00:23:37,290 +الميزانية في الميزانية في الميزانية في الميزانية + +268 +00:23:37,290 --> 00:23:41,630 +في الميزانية في الميزانية في الميزانية + +269 +00:23:41,630 --> 00:23:53,330 +فيعند إعادة سطربوكس ستتغير الوضع بالكامل فقط اقوم + +270 +00:23:53,330 --> 00:24:00,310 +بالتخصيص و اقوم بالتخصيص ولكن سطربوكس + +271 +00:24:00,310 --> 00:24:08,670 +12% وإمارسون 8% وليس 9% وسنرى كيف ستتغير عدد الوضع + +272 +00:24:08,670 --> 00:24:09,010 +بالكامل + +273 +00:24:12,450 --> 00:24:23,070 +فهو 9% لماذا 9%؟ لأن الاريسون أزالة ما + +274 +00:24:23,070 --> 00:24:29,430 +يمكننا + +275 +00:24:29,430 --> 00:24:34,290 +أن نتعرف عنه هو البرتفالية يمكن أن يكون بورتفاليه + +276 +00:24:34,290 --> 00:24:39,710 +أقل حرارة من حرارة عادية لإستخدامه في البرتفالي + +277 +00:24:41,000 --> 00:24:43,620 +النقطة الثانية لإنقاذ الرخصية من خلال الـ + +278 +00:24:43,620 --> 00:24:47,300 +diversification هي أن تجمع المستخدمين الذين لا + +279 +00:24:47,300 --> 00:24:52,900 +يتجمعون مع بعضًا لتجمع المستخدمين الذين لا يتجمعون + +280 +00:24:52,900 --> 00:24:56,100 +بعضًا لتجمع + +281 +00:24:56,100 --> 00:25:01,120 +المستخدمين الذين لا يتجمعون مع بعضًا لتجمع + +282 +00:25:01,120 --> 00:25:01,400 +المستخدمين الذين لا يتجمعون مع بعضًا لتجمع + +283 +00:25:01,400 --> 00:25:03,440 +المستخدمين الذين لا يتجمعون مع بعضًا لتجمع + +284 +00:25:03,440 --> 00:25:07,880 +المستخدمين الذين لا يتجمعون مع بعضًا لتجمع + +285 +00:25:07,880 --> 00:25:10,720 +المستخدمين الذين لا يتجمعون مع بعضًا لتجمع الم + +286 +00:25:11,290 --> 00:25:17,150 +التقارير بين الأسات أو الأمانات ولكن في الحالة + +287 +00:25:17,150 --> 00:25:21,470 +لتقرير الـ Sigma B أو المقارنة العامة من + +288 +00:25:21,470 --> 00:25:28,530 +البرتفاليو يجب أن نعود ونعتبر التقارير بين A وB + +289 +00:25:28,530 --> 00:25:32,970 +لتقرير + +290 +00:25:32,970 --> 00:25:42,920 +التقارير يجب أن نقرر رو رو هي التقارير بينانتقل من + +291 +00:25:42,920 --> 00:25:50,060 +واحد إلى نقل واحد من خلال نقل نقل نقل + +292 +00:25:50,060 --> 00:25:55,140 +نقل نقل + +293 +00:25:55,140 --> 00:25:59,920 +نقل نقل نقل نقل نقل نقل نقل نقل نقل نقل نقل نقل + +294 +00:25:59,920 --> 00:26:00,540 +نقل نقل نقل نقل نقل نقل نقل نقل نقل نقل نقل نقل + +295 +00:26:15,360 --> 00:26:22,020 +سنرى الفورمولة هنا صفحة صفحة صفحة صفحة صفحة صفحة + +296 +00:26:22,020 --> 00:26:22,480 +صفحة صفحة صفحة + +297 +00:26:35,380 --> 00:26:39,220 +مساعدة المستخدم الثاني المساعدة المستخدم الثاني + +298 +00:26:39,220 --> 00:26:40,060 +المساعدة المساعدة المساعدة المساعدة المساعدة + +299 +00:26:40,060 --> 00:26:40,460 +المساعدة المساعدة المساعدة المساعدة المساعدة + +300 +00:26:40,460 --> 00:26:42,340 +المساعدة المساعدة المساعدة المساعدة المساعدة + +301 +00:26:42,340 --> 00:26:44,120 +المساعدة المساعدة المساعدة المساعدة المساعدة + +302 +00:26:44,120 --> 00:26:45,000 +المساعدة المساعدة المساعدة المساعدة المساعدة + +303 +00:26:45,000 --> 00:26:45,960 +المساعدة المساعدة المساعدة المساعدة المساعدة + +304 +00:26:45,960 --> 00:26:46,100 +المساعدة المساعدة المساعدة المساعدة المساعدة + +305 +00:26:46,100 --> 00:27:03,960 +المساعدة المساعدة المساعدة المساعدة المسا + +306 +00:27:03,980 --> 00:27:08,960 +وهنا لا يوجد مشكلة في هذه الحالة إنها مثلًا W1 + +307 +00:27:08,960 --> 00:27:13,160 +Sigma 1 plus W2 وهو مشابه إلى عدد العودة ولكن + +308 +00:27:13,160 --> 00:27:17,720 +عندما نضيف هذا هذا هو الشيء المهم جدًا لأنه لديه + +309 +00:27:17,720 --> 00:27:22,140 +تأثير مباشر على مقارنة أساسية الميزانية للميزانية + +310 +00:27:22,140 --> 00:27:27,400 +فمرة أخرى الـRaw هي مقارنة عدد العودة بين عدد عدد + +311 +00:27:27,400 --> 00:27:28,380 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +312 +00:27:28,380 --> 00:27:30,080 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد عدد + +313 +00:27:30,080 --> 00:27:32,090 +عدد عدد عدد عدد عدد عدد عدد عدد عدد عدبالتالي، + +314 +00:27:32,090 --> 00:27:35,710 +الوثيقة رو تشير إلى مقارنة مقارنة بين مقارنة + +315 +00:27:35,710 --> 00:27:36,270 +مقارنة مقارنة مقارنة مقارنة مقارنة مقارنة مقارنة + +316 +00:27:36,270 --> 00:27:37,250 +مقارنة مقارنة مقارنة مقارنة مقارنة مقارنة مقارنة + +317 +00:27:37,250 --> 00:27:37,810 +مقارنة مقارنة مقارنة مقارنة مقارنة مقارنة مقارنة + +318 +00:27:37,810 --> 00:27:39,950 +مقارنة مقارنة مقارنة مقارنة مقارنة مقارنة مقارنة + +319 +00:27:39,950 --> 00:27:47,330 +مقارنة مقارنة + +320 +00:27:47,330 --> 00:27:56,370 +مقارنة مOkay very simple I will show you in the + +321 +00:27:56,370 --> 00:27:59,810 +lab how we can calculate this and by the way in + +322 +00:27:59,810 --> 00:28:02,650 +your assignment you have to calculate this not in + +323 +00:28:02,650 --> 00:28:04,650 +the financial management assignment in the + +324 +00:28:04,650 --> 00:28:07,910 +financial analysis and I delivered the assignments + +325 +00:28:07,910 --> 00:28:12,690 +in the website okay just take a look at this okay + +326 +00:28:12,690 --> 00:28:15,770 +so very enjoyment many enjoyments around + +327 +00:28:18,550 --> 00:28:23,090 +حسنًا إذا قمنا بالتخطيط الوضعي الوضعي الوضعي + +328 +00:28:23,090 --> 00:28:25,230 +الوضعي الوضعي الوضعي الوضعي الوضعي الوضعي الوضعي + +329 +00:28:25,230 --> 00:28:29,750 +الوضعي الوضعي الوضعي + +330 +00:28:29,750 --> 00:28:31,790 +الوضعي الوضعي الوضعي الوضعي الوضعي الوضعي الوضعي + +331 +00:28:31,790 --> 00:28:36,190 +الوضعي الوضعي الوضعي الوضعي الوضعي الوضعي الوضعي + +332 +00:28:36,190 --> 00:28:47,050 +الوض + +333 +00:28:48,450 --> 00:28:52,990 +دعونا نعود إلى المثال الـ Starbucks إذا كان لدينا + +334 +00:28:52,990 --> 00:29:00,450 +مجموعة تحتوي أو تجمع Starbucks و Costa، فانتجتان + +335 +00:29:00,450 --> 00:29:04,450 +شركات تعمل في نفس المنطقة، لذا نتوقع أن التقارير + +336 +00:29:04,450 --> 00:29:11,580 +بينهم سيكون عالي، لذلك صعب أن يكونtwo two + +337 +00:29:11,580 --> 00:29:14,140 +companies working in the same area in the in the + +338 +00:29:14,140 --> 00:29:17,860 +same portfolio okay take another example google + +339 +00:29:17,860 --> 00:29:21,720 +and yahoo so both google and yahoo together it + +340 +00:29:21,720 --> 00:29:25,540 +doesn't mean anything just there is no + +341 +00:29:25,540 --> 00:29:28,990 +diversificationعلى الرغم من أن لدينا اتصالات + +342 +00:29:28,990 --> 00:29:32,170 +مختلفة لكن اتصالات مختلفة تعمل في نفس المنطقة و + +343 +00:29:32,170 --> 00:29:36,010 +يقاتلوا بعضها البعض ولكن انظر هنا في هذه الحالة + +344 +00:29:36,010 --> 00:29:41,770 +لدينا أبل و لدينا كوك أبل تعمل في مجالات مختلفة و + +345 +00:29:41,770 --> 00:29:49,150 +كوك ولكنهم لديهم راو هو 0.75 فهذه + +346 +00:29:49,150 --> 00:29:56,950 +أشياء مذهلة عندما تبحث عنالـ Apple و Coca-Cola على + +347 +00:29:56,950 --> 00:30:00,370 +أية حال سوف نشاهد مثال مختلف حاول أن تدرس نفسك فقط + +348 +00:30:00,370 --> 00:30:03,870 +تحميل بعض البيانات من الـ London Stock Exchange أو + +349 +00:30:03,870 --> 00:30:10,130 +من الـ Palestine Stock Exchange أو من New York + +350 +00:30:10,130 --> 00:30:15,070 +Stock Exchange وحاول تحميل الوصول اليومي لتشاهد + +351 +00:30:15,070 --> 00:30:20,740 +التعامل بين الشركات المختلفةكيف نتخيل الـR بسيطة + +352 +00:30:20,740 --> 00:30:23,940 +جدا رمز رمز رمز رمز رمز رمز رمز رمز رمز رمز رمز + +353 +00:30:23,940 --> 00:30:26,300 +رمز رمز رمز رمز رمز رمز رمز رمز رمز رمز رمز رمز + +354 +00:30:26,300 --> 00:30:30,400 +رمز رمز رمز رمز رمز رمز رمز رمز رمز رمز رمز رمز + +355 +00:30:30,400 --> 00:30:32,600 +رمز رمز رمز رمز رمز رمز رمز رمز رمز رمز رمز رمز + +356 +00:30:32,600 --> 00:30:34,800 +رمز رمز رمز رمز رمز رمز رمز رمز رمز رمز رمز رمز + +357 +00:30:34,800 --> 00:30:45,400 +رمز رمز رمز رمز رمز رمز رمز رمز رمز رمز ر + +358 +00:30:47,740 --> 00:30:55,840 +Okay so the root of w one squared so fifty squared + +359 +00:30:55,840 --> 00:31:05,660 +times fourteen squared plus fifty squared fourteen + +360 +00:31:05,660 --> 00:31:12,600 +squared then plus two weight + +361 +00:31:12,600 --> 00:31:13,280 +fifty + +362 +00:31:30,460 --> 00:31:34,540 +مش فارقين يعني مش فارقين + +363 +00:31:40,160 --> 00:31:49,700 +هذه وهذه اول اشياء هذه بقى فوق 90 + +364 +00:31:49,700 --> 00:31:54,940 +يعني this is sigma square w this is what you mean + +365 +00:31:54,940 --> 00:32:04,740 +it means w one squared sigma one squared اه + +366 +00:32:04,740 --> 00:32:06,120 +اشياء اه okay okay + +367 +00:32:10,380 --> 00:32:14,920 +Okay and this So + +368 +00:32:14,920 --> 00:32:21,200 +this is right here Okay So + +369 +00:32:21,200 --> 00:32:28,460 +the expected rate of return is 14 Then As we said + +370 +00:32:28,460 --> 00:32:32,740 +here, now the most important thing is here The + +371 +00:32:32,740 --> 00:32:38,840 +point 75, the correlation coefficient If we change + +372 +00:32:38,840 --> 00:32:39,220 +this + +373 +00:32:42,900 --> 00:32:46,380 +سيتغير الانتجة العامة فإن انتجة الانتجة العامة في + +374 +00:32:46,380 --> 00:32:53,880 +هذا الميزاني 18.7% إذا أخذنا عملة عملة عملة عملة + +375 +00:32:53,880 --> 00:32:59,660 +عملة أبل وكوكاكو كمية مالية ستجعل ميزانيا ميزانيا + +376 +00:32:59,660 --> 00:33:01,980 +عملة عملة عملة عملة عملة عملة عملة عملة عملة عملة + +377 +00:33:01,980 --> 00:33:02,280 +عملة عملة عملة عملة عملة عملة عملة عملة عملة عملة + +378 +00:33:02,280 --> 00:33:02,380 +عملة عملة عملة عملة عملة + +379 +00:33:09,040 --> 00:33:15,120 +بالنسبة للتواصل مثلا sigma b بدون أن نعتبر تأثير + +380 +00:33:15,120 --> 00:33:22,780 +الرقم فسيكون مثل هذا نقطة و 50 مرة و 20 مرة هي + +381 +00:33:22,780 --> 00:33:32,240 +sigma و نقطة و 50 مرة و 20 مرة فسigma b ستكون 20% + +382 +00:33:35,890 --> 00:33:41,810 +لكن المشكلة هي أن هناك مقارنة بين الاتنين الشركات + +383 +00:33:41,810 --> 00:33:48,190 +منذ أن المقارنة أقل من واحدة لذا فهي 0.775 فإنها + +384 +00:33:48,190 --> 00:33:56,310 +تقل رحلة البرتفاليو إلى 0.18% وستشاهد الانفلوكسية + +385 +00:33:56,310 --> 00:34:03,270 +إذا عدت إلى 18.7% لذلك هذه التقليل بسبب + +386 +00:34:05,010 --> 00:34:10,890 +ليس مقارنة مناسبة بين A وB لذلك الـ 25% يجعل + +387 +00:34:10,890 --> 00:34:18,430 +المقارنة أو يجعل المقارنة أقل من الشركات الوحيدة + +388 +00:34:18,430 --> 00:34:27,670 +حسنًا، + +389 +00:34:27,670 --> 00:34:29,430 +انظر إلى هذا التعريف + +390 +00:34:33,060 --> 00:34:39,300 +هذه هي مقاومة التقارير إذا + +391 +00:34:39,300 --> 00:34:44,000 +كانت واحدة التقارير بين اتنين شركات فالخطر في هنا + +392 +00:34:44,000 --> 00:34:50,080 +هذا هو الخطر إذا كانت أقل من واحدة فالخطر قريب من + +393 +00:34:50,080 --> 00:34:54,120 +نصف لذلك + +394 +00:34:54,120 --> 00:34:59,060 +أقل التقارير بين اتنين شركات واحدة أكتر من + +395 +00:34:59,060 --> 00:35:08,130 +الافعاليات من تقليل الخطربالنسبة لهذا المقارنة إذا + +396 +00:35:08,130 --> 00:35:10,110 +كانت مقارنة مقارنة مقارنة مقارنة مقارنة مقارنة + +397 +00:35:10,110 --> 00:35:10,550 +مقارنة مقارنة مقارنة مقارنة مقارنة مقارنة مقارنة + +398 +00:35:10,550 --> 00:35:13,630 +مقارنة مقارنة مقارنة مقارنة مقارنة مقارنة مقارنة + +399 +00:35:13,630 --> 00:35:14,590 +مقارنة مقارنة مقارنة مقارنة مقارنة مقارنة مقارنة + +400 +00:35:14,590 --> 00:35:24,330 +مقارنة مقارنة مقارنة مقارنة مقارنة مقارنة مقارنة + +401 +00:35:24,330 --> 00:35:29,510 +مقار + +402 +00:35:30,690 --> 00:35:35,590 +أسعار مع مقاومة أقل من نصف لتحصل على أفضل من + +403 +00:35:35,590 --> 00:35:42,530 +الانتجارات انظر إلى هذا الفيجوري من نقل من واحد + +404 +00:35:42,530 --> 00:35:46,130 +لدينا مقاومة عامة نصف نصف انظر إلى الـ retain ليس + +405 +00:35:46,130 --> 00:35:51,930 +مدهشا ليس مدهشا من نقطة أو من المقاومة مقاومة + +406 +00:35:51,930 --> 00:35:57,010 +التعامل لكن انظر إلى واحدIt is the highest, the + +407 +00:35:57,010 --> 00:36:00,150 +highest standard deviation or the highest. So the + +408 +00:36:00,150 --> 00:36:05,010 +format here or the formula is the standard + +409 +00:36:05,010 --> 00:36:10,610 +deviation of the portfolio is influenced by the + +410 +00:36:10,610 --> 00:36:16,610 +correlation between the assets. The more we reduce + +411 +00:36:16,610 --> 00:36:19,930 +the correlation between the assets, the more we + +412 +00:36:19,930 --> 00:36:23,810 +benefit from the diversification. Okay. + +413 +00:36:26,430 --> 00:36:33,790 +والتقارير يتواصل من plus one to minus one سوف + +414 +00:36:33,790 --> 00:36:40,530 +أتوقف هنا و أراكم في المجلد القادم. أراكم ان شاء + +415 +00:36:40,530 --> 00:36:42,730 +الله في اليوم الماضي و تكمنوا عافية + diff --git a/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/wj8N04gixi0.srt b/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/wj8N04gixi0.srt new file mode 100644 index 0000000000000000000000000000000000000000..3a0b5cea7ec7c2277dbddd8fc5f94511bf1d6662 --- /dev/null +++ b/PL9fwy3NUQKwbz0wqqxAKev7f0n-My8_SD/wj8N04gixi0.srt @@ -0,0 +1,1391 @@ +1 +00:00:20,820 --> 00:00:26,120 +ال... المرة الفاتة حكينا بال... حكينا بالألفة + +2 +00:00:26,120 --> 00:00:31,540 +Geometric method وحكينا بال... بال standard + +3 +00:00:31,540 --> 00:00:36,200 +deviation والـ risk and how we evaluate risk today + +4 +00:00:36,200 --> 00:00:38,200 +I'm going to talk about the efficient market + +5 +00:00:38,200 --> 00:00:44,470 +hypothesis ما يعنيه Hypothesis السوق المفيد يعني أن + +6 +00:00:44,470 --> 00:00:52,310 +كل المعلومات المتوفرة يجب أن تكون مجموعة في السعر، + +7 +00:00:52,310 --> 00:00:58,530 +فهذه هي Hypothesis السوق المفيد إذا لم يفشل السعر أن + +8 +00:00:58,530 --> 00:01:02,990 +يتفرج على المعلومات المتوفرة، يعني أن السوق غير + +9 +00:01:02,990 --> 00:01:10,380 +مفيد. السؤال هو ما هي المعلومات؟ نستطيع أن نسجل + +10 +00:01:10,380 --> 00:01:13,820 +المعلومات إلى ثلاثة مقالات أساسية، الأولى هي + +11 +00:01:13,820 --> 00:01:17,300 +المعلومات التاريخية، والثانية هي المعلومات الشخصية + +12 +00:01:17,300 --> 00:01:21,740 +أو المعلومات الأساسية، والثالثة هي المعلومات + +13 +00:01:21,740 --> 00:01:26,440 +الخاصة، إلى مدى ما يشبه مجتمعات هذه المعلومات + +14 +00:01:26,440 --> 00:01:31,380 +تعتبر مجتمعات قوية أو مجتمعات قوية أو مجتمعات قوية + +15 +00:01:31,380 --> 00:01:37,960 +أو قوية. General speaking in the efficient market + +16 +00:01:37,960 --> 00:01:42,440 +hypothesis people or investors cannot get abnormal + +17 +00:01:42,440 --> 00:01:46,800 +rate of return because the efficient market + +18 +00:01:46,800 --> 00:01:52,240 +treated people fairly and the return is equal the + +19 +00:01:52,240 --> 00:02:00,040 +risk. نحن لدينا اتصالين مختلفة بعض الانتجار الانتجار + +20 +00:02:00,040 --> 00:02:05,840 +الانتجاري يجدون أن السوق أفضل والآخرين يجدون أن + +21 +00:02:05,840 --> 00:02:12,300 +السوق ليس أفضل. أعتقد أنه لا مشكلة بين الانتجارين + +22 +00:02:12,300 --> 00:02:17,220 +إذا كان السوق أفضل أو ليس أفضل بشكل عام بالنسبة + +23 +00:02:17,220 --> 00:02:21,860 +للسوق الانتجاري يمكن أن يكون غير أفضل في اتصال + +24 +00:02:21,860 --> 00:02:26,170 +قصير. في الفترة القصيرة في الفترة القصيرة أقصد في + +25 +00:02:26,170 --> 00:02:35,270 +فترة قصيرة لنرى أقل من أقل + +26 +00:02:35,270 --> 00:02:41,370 +من عام واحد في يوم و أشهر محدد. لذلك نستطيع أن + +27 +00:02:41,370 --> 00:02:44,590 +نعتبر أن السوق غير إيجابي، ولكن في الوقت الطويل هو + +28 +00:02:44,590 --> 00:02:47,310 +غير إيجابي، ولكن في الفترة القصيرة إذا تكلمنا عن + +29 +00:02:47,310 --> 00:02:51,190 +الفترة القصيرة، في الفترة القصيرة السوق هو إيجابي. + +30 +00:02:52,870 --> 00:02:58,530 +هذه هي فكرة Hypothesis السوق الواضح أنه ممكن أن يكون + +31 +00:02:58,530 --> 00:03:12,010 +هناك تجارب + +32 +00:03:12,010 --> 00:03:16,950 +مفيدة مفيدة مفيدة مفيدة مفيدة مفيدة مفيدة مفيدة + +33 +00:03:16,950 --> 00:03:16,970 +مفيدة مفيدة مفيدة مفيدة مفيدة مفيدة مفيدة مفيدة + +34 +00:03:16,970 --> 00:03:16,990 +مفيدة مفيدة مفيدة مفيدة مفيدة مفيدة مفيدة مفيدة + +35 +00:03:16,990 --> 00:03:17,450 +مفيدة مفيدة مفيدة مفيدة مفيدة مفيدة مفيدة مفيد + +36 +00:03:17,980 --> 00:03:23,820 +والفكرة الرئيسية لهذه التقريرية هي المعلومات + +37 +00:03:23,820 --> 00:03:32,320 +المتوفرة أو المعلومات المتوفرة هي أن كل + +38 +00:03:32,320 --> 00:03:37,100 +المعلومات عن محافظة السلاسل تم تفكيرها تماما في + +39 +00:03:37,100 --> 00:03:42,120 +أسعار السوق. ففي السوق الضعيف فإن السوق الضعيف فقط + +40 +00:03:42,120 --> 00:03:47,880 +تفكير أسعار السوق التاريخية. هذا يعني أن جميع السعر + +41 +00:03:47,880 --> 00:03:52,300 +والسطوع السعر أعني السعر السوقي والسطوع هو السطوع + +42 +00:03:52,300 --> 00:03:57,600 +التجاربي. المعلومات تم تفكيرها في الأمن على سبيل + +43 +00:03:57,600 --> 00:04:03,380 +المثال. إذا كان لديك السلسلة الوقت هذه سلسلة الوقت + +44 +00:04:03,380 --> 00:04:11,760 +لإنها وقت يقول أي يوم وهذا هو السعر هذه + +45 +00:04:11,760 --> 00:04:19,520 +هي السعر. هو يقوم بتحقيق الأسعار والتداول أيضًا يقوم + +46 +00:04:19,520 --> 00:04:24,900 +بتحقيق التداول هو أو هي لا يستطيع الحصول على أفضل + +47 +00:04:24,900 --> 00:04:31,920 +من هذه التحقيقات لأن هذه أسعار تاريخية. وهذا السبب + +48 +00:04:31,920 --> 00:04:37,180 +إذا كان المستخدمين يعتبروا التحقيق أو يضعوا الكثير + +49 +00:04:37,180 --> 00:04:41,040 +من الوقت على فهم التحقيق، فلن يتمكنوا من الحصول من + +50 +00:04:41,040 --> 00:04:47,160 +هذا التحقيق لأنه بالفعل مرتبط في السوق المالي، + +51 +00:04:47,160 --> 00:04:49,600 +خصوصًا في الأسلحة الأسلحة الأسلحة الأسلحة الأسلحة + +52 +00:04:49,600 --> 00:04:51,120 +الأسلحة الأسلحة الأسلحة الأسلحة الأسلحة الأسلحة + +53 +00:04:51,120 --> 00:04:53,300 +الأسلحة الأسلحة الأسلحة الأسلحة الأسلحة الأسلحة + +54 +00:04:53,300 --> 00:04:55,140 +الأسلحة الأسلحة الأسلحة الأسلحة الأسلحة الأسلحة + +55 +00:04:55,140 --> 00:05:00,710 +الأسلحة الأسلحة الأسلحة الأسلحة الأسلحة الأهو يشبه + +56 +00:05:00,710 --> 00:05:04,050 +البيانات الأساسية البيانات الأساسية أو البيانات + +57 +00:05:04,050 --> 00:05:08,050 +المتوفرة بشكل عام. البيانات الأساسية تتضمن البيانات + +58 +00:05:08,050 --> 00:05:09,330 +الأساسية البيانات الأساسية البيانات الأساسية + +59 +00:05:09,330 --> 00:05:09,910 +البيانات الأساسية البيانات الأساسية البيانات + +60 +00:05:09,910 --> 00:05:10,270 +الأساسية البيانات الأساسية البيانات الأساسية + +61 +00:05:10,270 --> 00:05:10,690 +البيانات الأساسية البيانات الأساسية البيانات + +62 +00:05:10,690 --> 00:05:11,490 +الأساسية البيانات الأساسية البيانات الأساسية + +63 +00:05:11,490 --> 00:05:12,790 +البيانات الأساسية البيانات الأساسية البيانات + +64 +00:05:12,790 --> 00:05:13,030 +الأساسية البيانات الأساسية البيانات الأساسية + +65 +00:05:13,030 --> 00:05:14,270 +البيانات الأساسية البيانات الأساسية البيانات + +66 +00:05:14,270 --> 00:05:18,310 +الأساسية البيانات + +67 +00:05:18,310 --> 00:05:21,010 +الأساسية + +68 +00:05:25,890 --> 00:05:29,490 +ولكن إذا كانوا المستخدمين يدخلوا مجتمع أساسي، في + +69 +00:05:29,490 --> 00:05:34,990 +مجتمع أساسي، إذا كانوا الناس يتعاملوا مع المعلومات + +70 +00:05:34,990 --> 00:05:40,300 +الأساسية، فهم يستطيعون الحصول على إيجار. والعكس من + +71 +00:05:40,300 --> 00:05:43,480 +ذلك، إذا كانوا يفعلوا ذلك في مجتمع متوسط، فلا + +72 +00:05:43,480 --> 00:05:46,080 +يمكنهم الحصول على إيجارات، لأن في السوق الضعيف، + +73 +00:05:46,080 --> 00:05:50,600 +السوق الضعيف فقط يتم تفكير المعلومات التاريخية، + +74 +00:05:50,600 --> 00:05:54,520 +ولكن في المعلومات الأساسية والمعلومات التاريخية تم + +75 +00:05:54,520 --> 00:06:00,600 +تفكيرها في مجتمعات متوسط، فهذه هي فكرة مجتمعات + +76 +00:06:00,600 --> 00:06:01,160 +متوسط. + +77 +00:06:03,980 --> 00:06:07,640 +للعامات القوية، العامات القوية تشير إلى البيانات + +78 +00:06:07,640 --> 00:06:15,600 +التاريخية والبيانات الأساسية والبيانات الخاصة. لذا + +79 +00:06:15,600 --> 00:06:19,440 +ثلاثة أشياء مختلفة من البيانات تشير إلى الأسعار + +80 +00:06:19,440 --> 00:06:22,580 +وما + +81 +00:06:22,580 --> 00:06:27,020 +يعنيه البيانات الخاصة في البيانات الخاصة يعني + +82 +00:06:27,020 --> 00:06:28,720 +المعلومات + +83 +00:06:33,110 --> 00:06:39,970 +هو المعلومات المرتبطة بالمخلوقات + +84 +00:06:39,970 --> 00:06:51,470 +المخلوقات السوق. هذه هي المعلومات الخاصة وهي + +85 +00:06:51,470 --> 00:06:57,270 +مفتوحة فقط للمحافظين المخلوقات المخلوقات المخلوقات + +86 +00:06:57,270 --> 00:06:59,330 +المخلوقات المخلوقات المخلوقات المخلوقات المخلوقات + +87 +00:06:59,330 --> 00:07:04,980 +المخلوقات المخلوقات أو بعض الاستثمارات الانستجرامية + +88 +00:07:04,980 --> 00:07:09,760 +في هذا المستوى، لا يجب أن ندخل في مقدمة على فهم من + +89 +00:07:09,760 --> 00:07:13,680 +هم الشركات المدخلين، ولكن في دراسة الانستجرامات + +90 +00:07:13,680 --> 00:07:18,960 +تدخل عن من هم الشركات المدخلين، ولكن بمعرفة عامة، + +91 +00:07:18,960 --> 00:07:22,060 +المعلومات الخاصة هي المعلومات المرتبطة بالشركات + +92 +00:07:22,060 --> 00:07:26,920 +المدخلين، على سبيل المثال، أعطيك مثال عن المعلومات + +93 +00:07:26,920 --> 00:07:27,100 +الخاصة. + +94 +00:07:32,480 --> 00:07:37,960 +مثلًا، هذا هو السوق الاجتماعي هؤلاء هم المحادثين + +95 +00:07:37,960 --> 00:07:46,060 +المحادثين هنا وهم السوق الاجتماعي هنا لا يوجد + +96 +00:07:46,060 --> 00:07:51,940 +اتصال مباشر بين المستخدمين مع السوق الاجتماعي هنا + +97 +00:07:51,940 --> 00:07:58,280 +هم المخاطرين المخاطرين + +98 +00:07:58,280 --> 00:08:03,990 +هنا لديهم محفظة دعونا نرى إن هذا هو المحفظة. دعونا + +99 +00:08:03,990 --> 00:08:11,170 +نقول أن هذا الانفجار لإي بي أم. الانفجار + +100 +00:08:11,170 --> 00:08:16,770 +فقط يعرف مستوى المستوى المقابل لانفجار السوق أعني + +101 +00:08:16,770 --> 00:08:25,010 +انفجار السوق. دعونا نقول أن بعض المصادق يطلبون أن + +102 +00:08:25,010 --> 00:08:28,910 +يشتروا لإي + +103 +00:08:28,910 --> 00:08:29,250 +بي أم + +104 +00:08:32,630 --> 00:08:38,550 +الـ IBM هنا... الانفجار لـ IBM يجب أن يكون في هذا + +105 +00:08:38,550 --> 00:08:44,210 +المستوى يجب أن يكون في هذا المستوى... الأن هو في + +106 +00:08:44,210 --> 00:08:48,370 +هذا المستوى الأن + +107 +00:08:48,370 --> 00:08:53,450 +أكثر شراء الأسعار سيجعل هذه اللحظة تنزل + +108 +00:08:56,520 --> 00:09:02,840 +لتكون قريب من خطة الانفجار المفضلة، وإذا أصبحت + +109 +00:09:02,840 --> 00:09:07,140 +قريب من هذا الموضوع، فإن المحقق يحاول أن يجعل + +110 +00:09:07,140 --> 00:09:14,520 +السعر يتحرك لإنقاذ المستخدمين المضافين، فمن يعرف + +111 +00:09:14,520 --> 00:09:19,700 +الانفجار فقط المدخلين يعرفون الانفجار. لا يجب أن + +112 +00:09:19,700 --> 00:09:24,020 +نتكلم عن هذا في التفاصيل، لكن هذه هي الفكرة عن + +113 +00:09:24,020 --> 00:09:27,820 +المعلومات الخاصة، لا نقصد أن المعلومات الخاصة هي + +114 +00:09:27,820 --> 00:09:32,340 +... المعلومات الخاصة مثل بعض القرارات أو بعض + +115 +00:09:32,340 --> 00:09:36,720 +الترتيبات للعمل، حسنًا؟ لأن هذه المعلومات الأساسية + +116 +00:09:36,720 --> 00:09:40,840 +مرتبطة بالإعلانات عن هذا + +117 +00:09:45,280 --> 00:09:52,580 +والحبثة بشركة strong market هي أن المعلومات + +118 +00:09:52,580 --> 00:09:58,980 +المرتبطة لشركة معينة غير متوقعة والمعلومات غير + +119 +00:09:58,980 --> 00:10:04,560 +متوقعة، لا أحد يستطيع أن يتوقع ما هي المعلومات + +120 +00:10:04,560 --> 00:10:08,760 +الجديدة أو ما هي المعلومة. هذه السوق، الـ Strong + +121 +00:10:08,760 --> 00:10:13,500 +Market Hypothesis تشير إلى المعلومات التاريخية، + +122 +00:10:13,500 --> 00:10:17,860 +تشير إلى المعلومات الأساسية وتشير إلى المعلومات + +123 +00:10:17,860 --> 00:10:22,040 +الخاصة، + +124 +00:10:22,040 --> 00:10:30,320 +لكن السؤال هل نحن لدينا حيوانات قوية أو لا؟ أو + +125 +00:10:30,320 --> 00:10:36,180 +هل نحن نعتقد أن السوق 100% مفيد أو لا؟ هذه السؤال + +126 +00:10:36,180 --> 00:10:44,300 +الكبير، بشكل عام، السوق مفيد بشكل مزعج، ليس مفيد + +127 +00:10:44,300 --> 00:10:44,780 +100%. + +128 +00:10:51,500 --> 00:10:57,980 +لماذا؟ لأن هناك بعض الانفلوانات تجعل السعر يتجاوز + +129 +00:10:57,980 --> 00:11:06,580 +من أصولها وهناك قيمة خاطئة في السوق والقيمة + +130 +00:11:06,580 --> 00:11:11,120 +الخاطئة تعتبر غير مفيدة. السوق الانجلاليين يتوقعوا + +131 +00:11:11,120 --> 00:11:15,960 +أن يكونوا على الأقل ضعيفين وعلى الأقل مفيدين وهذا + +132 +00:11:15,960 --> 00:11:20,300 +على الأقل، ولكن إذا أردنا نتحدث عن الـ Hypothesis + +133 +00:11:20,300 --> 00:11:25,900 +السلوكيلدينا أفكار حول هذا الموضوع. إذا كانت هناك + +134 +00:11:25,900 --> 00:11:29,400 +استراتيجية مفيدة بسيطة فإن استراتيجية كانت تدفع + +135 +00:11:29,400 --> 00:11:33,480 +إهتمام المستخدمين الذين بإمتلاك استراتيجية كانوا + +136 +00:11:33,480 --> 00:11:36,860 +يقاتلوا الناس من خارج الأموال. على سبيل المثال إذا + +137 +00:11:36,860 --> 00:11:39,920 +كانت + +138 +00:11:39,920 --> 00:11:46,920 +السوق مفيدة لا يعني أن السوق مفيدة 100%. + +139 +00:11:50,230 --> 00:11:57,690 +نعتبر أن إذا كانت السوق مفيدة فكل السوق الموجود في + +140 +00:11:57,690 --> 00:12:04,330 +خطوط السوق الحماية كل السوق. ولكن أحيانًا التجارب + +141 +00:12:04,330 --> 00:12:11,810 +الـ risk and return لا تعمل جيدًا أحيانًا + +142 +00:12:13,150 --> 00:12:17,250 +this relationship deviates from its intrinsic + +143 +00:12:17,250 --> 00:12:22,090 +value or intrinsic line, so the institutional + +144 +00:12:22,090 --> 00:12:29,750 +investors try to keep this deviation to its origin + +145 +00:12:31,090 --> 00:12:34,390 +Okay, I know this is very complicated for your head + +146 +00:12:34,390 --> 00:12:40,130 +but this is the idea of what I mean if if the + +147 +00:12:40,130 --> 00:12:43,330 +return if the relationship between the risk and + +148 +00:12:43,330 --> 00:12:48,270 +return is not going well, I mean this is the risk + +149 +00:12:48,270 --> 00:12:52,540 +and this is the return for this stock، ويجب أن يكون + +150 +00:12:52,540 --> 00:12:58,340 +هنا، وليس في هذه المنطقة، لذلك ميكانيزم السوق + +151 +00:12:58,340 --> 00:13:04,600 +يحاول أن يدفع هذا السوق إلى أن يكون في أصله، لذلك + +152 +00:13:04,600 --> 00:13:10,780 +هذه المنطقة معروفة، هذه المنطقة معروفة، وإذا كانت + +153 +00:13:10,780 --> 00:13:17,160 +معروفة، يعني أن السوق غير إيجابي، ولكن السوق غير + +154 +00:13:17,160 --> 00:13:20,780 +إيجابي في ثانوية معينة فقط، في ثانوية أو ثلاثة + +155 +00:13:20,780 --> 00:13:26,160 +ثانويات، ولكن في طرح طويلة السوق يكون إيجابيًا، لهذا + +156 +00:13:26,160 --> 00:13:30,240 +السبب، الناس اللي فوزوا نوبل برايز، نحن لدينا + +157 +00:13:30,240 --> 00:13:36,200 +أفعالين مختلفة، الشيلر قال إن السوق ليس إيجابيًا + +158 +00:13:36,200 --> 00:13:39,580 +وغينفاما قال إن السوق يكون إيجابيًا، لذلك لدينا + +159 +00:13:39,580 --> 00:13:45,410 +أفعالين مختلفة، لكن في الأوسطان كلا الناس صحيحة + +160 +00:13:45,410 --> 00:13:50,750 +بالنسبة للتقريب والمستقبل. في التقريب، في ثانوية + +161 +00:13:50,750 --> 00:13:53,590 +معينة، السوق ليس مفيد، ولكن إذا كنا نتكلم عن + +162 +00:13:53,590 --> 00:13:55,430 +المستقبل، فالسوق مفيد. + +163 +00:13:59,490 --> 00:14:04,510 +فأعتقد أن هذا ما يجب أن نقوله. لن نتوقع أن السوق + +164 +00:14:04,510 --> 00:14:09,750 +المالي يكون مفيد بطريقة قوية. نتوقع أن السوق سيكون + +165 +00:14:09,750 --> 00:14:14,310 +مفيد بشكل مجلس. ولكن ليس بشكل مميز، لا يوجد شيء + +166 +00:14:14,310 --> 00:14:20,950 +مميز، فقط الله مميز، يواجه المعلومات التي مجتمعها + +167 +00:14:20,950 --> 00:14:24,970 +خاصة، حتى لو كان لدينا المعلومات الخاصة، وهذه + +168 +00:14:24,970 --> 00:14:32,110 +المعلومات قد تتواجه بعد وقت طويل، دعنا نقول، على + +169 +00:14:32,110 --> 00:14:37,050 +سبيل المثال، لماذا نقول هذا؟ + +170 +00:14:40,230 --> 00:14:45,210 +إذا كنا في هنا، ولدينا معلومات جديدة، لدينا إعلان + +171 +00:14:45,210 --> 00:14:52,870 +جديد، معلومات جديدة، الآن نحن في وقت T، والمعلومات في + +172 +00:14:52,870 --> 00:15:00,930 +وقت، دعونا نقول في وقت 1، في هذه الحالة، في هذه + +173 +00:15:00,930 --> 00:15:05,970 +الحالة، المعلومات الجديدة لا يجب أن تتأثر على عادة + +174 +00:15:05,970 --> 00:15:12,310 +الأسهم، ولكن ما قد يحدث هو أنه بسبب المعلومات + +175 +00:15:12,310 --> 00:15:16,350 +الجديدة، ربما السعر أو محافظة الأسعار تتحرك حول + +176 +00:15:16,350 --> 00:15:23,270 +قيمة الانترنت، وإذا كانت تتحرك إلى الأسفل، بعد وقت + +177 +00:15:23,270 --> 00:15:28,510 +و5 ثانية، ستذهب إلى أصلها، أو إذا كانت تتحرك إلى + +178 +00:15:28,510 --> 00:15:34,570 +الأعلى، بعد وقت، وقت، ستذهب إلى أصلها، وهو فقط غير + +179 +00:15:34,570 --> 00:15:39,390 +مفيد، لذلك بسبب هذا الموضوع الناس، وخصوصًا + +180 +00:15:39,390 --> 00:15:42,670 +المستخدمين + +181 +00:15:42,670 --> 00:15:48,830 +المستخدمين الذين يلاحظون هذا، ويحاولون + +182 +00:15:48,830 --> 00:15:53,910 +أن يستخدموا مالهم في الأسعار المفارقة، لماذا + +183 +00:15:53,910 --> 00:15:57,590 +يستخدموا؟ لأن في الأسعار المفارقة يحصلوا على عدد + +184 +00:15:57,590 --> 00:16:00,450 +أعلى، هذا هو الأول، الشيء الثاني هو أن تبقى + +185 +00:16:00,450 --> 00:16:04,800 +الأسعار على أصلها، لذلك يحاولون أن يقوموا بإصلاح + +186 +00:16:04,800 --> 00:16:10,860 +السوق، لذلك يلاحظوا أين المسارات. إذا كان هناك + +187 +00:16:10,860 --> 00:16:15,720 +مسارات، فإنهم يدخلوا في السوق أولًا، لحصول على عدد + +188 +00:16:15,720 --> 00:16:20,500 +أعلى، ثانيًا، لإصلاح السوق. لذلك يجعلون السوق مصادر + +189 +00:16:21,870 --> 00:16:24,630 +هذه السبب، لأنه في الفترة لدينا شركات غير إيجابية + +190 +00:16:24,630 --> 00:16:29,430 +وفي المدى لدينا شركات إيجابية، السوق سيكونوا غير + +191 +00:16:29,430 --> 00:16:33,670 +إيجابيين بما يكفي لإعطاء بعض المستخدمين فرصة + +192 +00:16:33,670 --> 00:16:37,710 +لإعادة قيمة الحصول على المعلومات، لأنهم لديهم + +193 +00:16:37,710 --> 00:16:41,150 +المعلومات الخاصة، ولكن ليسوا غير إيجابيين، فهناك + +194 +00:16:41,150 --> 00:16:45,430 +أسهل المال يمكن أن يتم صنعه في السوق الإيجابيين، في + +195 +00:16:45,430 --> 00:16:48,550 +السوق الإيجابيين، هيبثيز، هيبثيز على الوصولة بأن + +196 +00:16:48,550 --> 00:16:56,600 +المستخدمين كجماعة، مفهوم، هذه النظرات تم تحديدها، + +197 +00:16:56,600 --> 00:16:59,700 +لسنا نعتبرها باعتبار النظرات الأخيرة في السوق + +198 +00:16:59,700 --> 00:17:04,980 +الماليين، النظرات الأساسية للسوق الماليين التي تم + +199 +00:17:04,980 --> 00:17:09,440 +دعمها أوجين فامر، قالت إن السوق مفيد بسبب أن + +200 +00:17:09,440 --> 00:17:15,860 +المستخدمين غير حسنين، حسنين، المستخدمين غير حسنين، + +201 +00:17:15,860 --> 00:17:20,690 +لكن في الحقيقة بأعتبار النظرات التعاملية، العاملين + +202 +00:17:20,690 --> 00:17:24,450 +ليسوا غير صحيحين، غير صحيحين، لأن إذا كانت لديك + +203 +00:17:24,450 --> 00:17:30,130 +المعلومات، وهذه المعلومات صحيحة، وصحيحة، بعض الناس + +204 +00:17:30,130 --> 00:17:37,030 +لديها انتباهات مختلفة لهذه المعلومات، على سبيل + +205 +00:17:37,030 --> 00:17:43,210 +المثال، إذا قررت الشركة تدفع دفعات، تدفع دفعات، و + +206 +00:17:47,580 --> 00:17:51,960 +these people know that tomorrow or now the market + +207 +00:17:51,960 --> 00:17:56,820 +or today it is announced that this company will + +208 +00:17:56,820 --> 00:18:01,850 +pay out، هذا حسنًا، بعض الناس تقرر هذا بطريقات + +209 +00:18:01,850 --> 00:18:04,250 +مختلفة، بعض الناس تقول إنه ليس كثير من المال، لا + +210 +00:18:04,250 --> 00:18:12,030 +يمكن أن يتفكر في السوق، ربما هذا .. هذا .. هو مال + +211 +00:18:12,030 --> 00:18:14,950 +من الـ retained earnings من السنوات السابقة، وما + +212 +00:18:14,950 --> 00:18:18,690 +إلى ذلك، لذلك، منافسات مختلفة، مع منافسات مختلفة + +213 +00:18:18,690 --> 00:18:22,790 +ماذا + +214 +00:18:22,790 --> 00:18:26,740 +إذا كانت الاستثمارات غير عقلية، and this is not + +215 +00:18:26,740 --> 00:18:30,340 +rational if they have different interpretations + +216 +00:18:30,340 --> 00:18:37,240 +okay, so if I give you, you ask me about your exam + +217 +00:18:37,240 --> 00:18:42,330 +or your quiz, I say fine، ما يعنيه fine، بعض الناس + +218 +00:18:42,330 --> 00:18:48,390 +يقولون fine، لديهم تلقاءات مختلفة، fine لك مختلفة + +219 +00:18:48,390 --> 00:18:53,850 +من fine لك ولأشخاص آخرين، فالأشياء تعتمد على مدى + +220 +00:18:53,850 --> 00:19:00,010 +فهمك هذه المعلومة، ونفقنا أن الناس لديها تلقاءات + +221 +00:19:00,010 --> 00:19:04,870 +مختلفة، يعتمد على نفسك، يعتمد على فهمك، وهذا + +222 +00:19:04,870 --> 00:19:06,810 +يجعلنا نتحدث عن نظر التعامل + +223 +00:19:09,510 --> 00:19:19,250 +هناك مثال جميل هنا، إذا + +224 +00:19:19,250 --> 00:19:28,150 +كان لدينا مجموعة من الحيوانات، دعونا + +225 +00:19:28,150 --> 00:19:31,230 +نرى فالقون + +226 +00:19:38,350 --> 00:19:43,870 +إيش معناه اللي فعلتونها؟ سمك كبير، يعني إيش اللي + +227 +00:19:43,870 --> 00:19:50,350 +أمركن بيها هيك، anyway + +228 +00:19:50,350 --> 00:19:58,550 +إيش إبن السقور، ولا إيش بتبينته؟ بغض النظر، we have + +229 +00:20:05,830 --> 00:20:12,910 +في عندنا مجموعة سقور مثلًا، وفي عندنا طير هان، شوفوا + +230 +00:20:12,910 --> 00:20:17,750 +ال misinterpretation، وفي عندنا هان طير فهو he + +231 +00:20:17,750 --> 00:20:23,810 +observing this group، then هذا في different kind + +232 +00:20:23,810 --> 00:20:27,550 +يعني نوع آخر، يعني نفترض أن هو كان نسر مثلًا، أو + +233 +00:20:27,550 --> 00:20:32,050 +نفترض أنه حمامة مثلًا، بقى ساكيد راح يكلوها، and some + +234 +00:20:32,050 --> 00:20:38,300 +people observing، people think هدول هما سقور، and if + +235 +00:20:38,300 --> 00:20:41,640 +this guy joined this group، they think this guy + +236 +00:20:41,640 --> 00:20:48,540 +also سقر، but in reality is not، so it doesn't mean + +237 +00:20:48,540 --> 00:20:52,620 +that the company announced dividends it is a good + +238 +00:20:52,620 --> 00:20:56,940 +company، okay, so this is the idea، it doesn't mean + +239 +00:20:56,940 --> 00:21:01,930 +this guy joined this group is strong، So what's + +240 +00:21:01,930 --> 00:21:04,270 +what's exactly going in the financial markets if + +241 +00:21:04,270 --> 00:21:07,270 +we have a good student sitting in this area for + +242 +00:21:07,270 --> 00:21:09,850 +instance، and we know this student sitting in this + +243 +00:21:09,850 --> 00:21:13,730 +area، and if another student sit with them، maybe + +244 +00:21:13,730 --> 00:21:16,890 +people think، oh، they are all of these students are + +245 +00:21:16,890 --> 00:21:19,770 +strong، but in reality not + +246 +00:21:21,490 --> 00:21:29,750 +ماذا بالضبط يحدث إذا كانوا الناس يكتبون ويكتبون + +247 +00:21:29,750 --> 00:21:30,370 +ويكتبون ويكتبون ويكتبون ويكتبون ويكتبون ويكتبون + +248 +00:21:30,370 --> 00:21:30,890 +ويكتبون ويكتبون ويكتبون ويكتبون ويكتبون ويكتبون + +249 +00:21:30,890 --> 00:21:31,350 +ويكتبون ويكتبون ويكتبون ويكتبون ويكتبون ويكتبون + +250 +00:21:31,350 --> 00:21:32,410 +ويكتبون ويكتبون ويكتبون ويكتبون ويكتبون ويكتبون + +251 +00:21:32,410 --> 00:21:32,710 +ويكتبون ويكتبون ويكتبون ويكتبون ويكتبون ويكتبون + +252 +00:21:32,710 --> 00:21:43,290 +ويكتبون ويكتبون ويكت + +253 +00:21:43,560 --> 00:21:47,140 +Don't think people put their heads and dries + +254 +00:21:47,140 --> 00:21:51,880 +things doing busy and sweating، okay, it doesn't + +255 +00:21:51,880 --> 00:21:55,780 +mean that they are working hard، it means yes + +256 +00:21:59,940 --> 00:22:07,280 +فبعض الناس عندما ألاحظ هذا، أنا غير عقل لو أعتقد أن + +257 +00:22:07,280 --> 00:22:11,500 +الناس مشغولة في فعل الأشياء الصحيحة، فهم يفعلون + +258 +00:22:11,500 --> 00:22:14,840 +الأشياء الصحيحة، ربما لا يفعلون الأشياء الصحيحة + +259 +00:22:14,840 --> 00:22:20,560 +لأنني ألاحظ هذا، دعونا نتحدث عن السوق، الخاصة، إذا + +260 +00:22:20,560 --> 00:22:25,160 +كنت تلاحظ بعض المستخدمين يأخذون قرارات، وانت تعرف أن + +261 +00:22:25,160 --> 00:22:31,880 +هؤلاء المستخدمين مستخدمين عالميين، وانت تشاهدهم لأن + +262 +00:22:31,880 --> 00:22:36,300 +لديك اعتبار أن هم مستخدمين عالميين، لديهم سيارة + +263 +00:22:36,300 --> 00:22:41,260 +عظيمة، لديهم مرساديس بنز، لديهم أشياء مثل هذه، ثم + +264 +00:22:41,260 --> 00:22:46,080 +إذا كنت تشاهدهم، تشاهدهم أنك تعتقد أنهم يأخذون + +265 +00:22:46,080 --> 00:22:51,680 +القرار الصحيح، فانت تحاول تسجيلهم، you try to cope + +266 +00:22:51,680 --> 00:22:56,540 +with them, you try to join them، and then what's + +267 +00:22:56,540 --> 00:22:59,220 +happened، you are irrational because you have to + +268 +00:22:59,220 --> 00:23:03,360 +know maybe these people not taking the right + +269 +00:23:03,360 --> 00:23:06,400 +decision، and this is lead us to talk about the + +270 +00:23:06,400 --> 00:23:12,440 +herd theory، herd، this is herd، the herd theory، + +271 +00:23:12,440 --> 00:23:17,300 +نظرية القطيع، نظرية القطيع بتقول أن هدول are strong + +272 +00:23:17,300 --> 00:23:20,620 +but it doesn't mean all of them are strong or + +273 +00:23:20,620 --> 00:23:24,920 +strong and you join them because you think oh I'm + +274 +00:23:24,920 --> 00:23:27,340 +strong because I'm with this guy but generally + +275 +00:23:27,340 --> 00:23:34,140 +not, maybe this .. يعني إذا واحد بتاخذ قرار صح هو + +276 +00:23:34,140 --> 00:23:38,080 +إيش اللي بيصير؟ هو موجود واحد هنا، he's the leader + +277 +00:23:39,790 --> 00:23:45,710 +وكلهم يتبعونه، فالرجل يقف ويقول اه انهم يتبعونه ثم + +278 +00:23:45,710 --> 00:23:54,090 +أنه أو أنها تتبع الاستجابة لكنها مثل مقاطعهم، لكن + +279 +00:23:54,090 --> 00:23:57,330 +هذا يعني أن هذا الرجل راسيونال ربما، لكن هؤلاء + +280 +00:23:57,330 --> 00:24:01,450 +الرجلين ليسوا راسيونال، واحد منهم يمكن أن يفعل + +281 +00:24:01,450 --> 00:24:03,590 +الأشياء الصحيحة في الاختبار وآخرين لا + +282 +00:24:06,590 --> 00:24:13,450 +الخيارات مرة أخرى، بعض المستخدمين ليسوا حسنيين، إذا + +283 +00:24:13,450 --> 00:24:14,530 +لم يكن المستخدمون يعملون عملية عملية عملية عملية + +284 +00:24:14,530 --> 00:24:15,430 +عملية عملية عملية عملية عملية عملية عملية عملية + +285 +00:24:15,430 --> 00:24:15,750 +عملية عملية عملية عملية عملية عملية عملية عملية + +286 +00:24:15,750 --> 00:24:16,910 +عملية عملية عملية عملية عملية عملية عملية عملية + +287 +00:24:16,910 --> 00:24:19,030 +عملية عملية عملية عملية عملية عملية عملية عملية + +288 +00:24:19,030 --> 00:24:24,670 +عملية عملية عملية عملية عملية عملية عملية عملية + +289 +00:24:24,670 --> 00:24:29,550 +عملية هذه الأشياء الجديدة التي تتجه إلى التعامل + +290 +00:24:29,550 --> 00:24:34,410 +هي التعامل التجاري وهي أشياء جديدة ومعروفة جدًا + +291 +00:24:34,410 --> 00:24:39,610 +لأنها تتعامل في سيكولوجيك الخاص بك، فالمعارف لا + +292 +00:24:39,610 --> 00:24:41,930 +يمكن أن تتعامل بشكل صحيح حتى مع المعلومات الشخصية + +293 +00:24:41,930 --> 00:24:47,410 +لأن الناس لديها مفهومات مختلفة، على سبيل المثال، + +294 +00:24:47,410 --> 00:24:54,990 +نحن لدينا بعض المستثمرين أو الطلاب if I + +295 +00:24:54,990 --> 00:24:59,690 +give them very simple question they may get wrong + +296 +00:24:59,690 --> 00:25:02,810 +answers because they don't think our teacher give + +297 +00:25:02,810 --> 00:25:06,230 +us like this question so he or she think this is + +298 +00:25:06,230 --> 00:25:09,130 +very complicated and try to treat the questions in + +299 +00:25:09,130 --> 00:25:12,940 +this way لذلك مرة أخرى، فإن مؤمننا في هذه الأسواق + +300 +00:25:12,940 --> 00:25:17,620 +قد يتفاجأ عندما يعلن الوظيفة أنهم لديهم الكثير من + +301 +00:25:17,620 --> 00:25:21,300 +الوثيقة في رأيهم من شركاتهم من خلال قيمة حقيقية + +302 +00:25:21,300 --> 00:25:24,860 +ويحاولون تغيير الكثير من الضغط على المعلومات + +303 +00:25:24,860 --> 00:25:28,160 +المقدمة من خلال الوظيفة إذا كانوا لديهم معلومات + +304 +00:25:28,160 --> 00:25:33,320 +جديدة، فهي تفكرون أنهم لديهم وثقة في رأيهم، فالأمر + +305 +00:25:33,320 --> 00:25:36,270 +يجب أن يكون بهذه الطريقة بالتالي، هذه المعلومات + +306 +00:25:36,270 --> 00:25:39,570 +الجديدة، حتى إذا كانت مواصلة ومتوفرة بشكل مباشر، + +307 +00:25:39,570 --> 00:25:43,590 +لم تكن تماما مواصلة في أسعار السوقية + +308 +00:25:43,590 --> 00:25:49,670 +لأننا لدينا مقالات مختلفة مقالات مقالات مقالات + +309 +00:25:49,670 --> 00:25:49,770 +مقالات مقالات مقالات مقالات مقالات مقالات مقالات + +310 +00:25:49,770 --> 00:25:49,830 +مقالات مقالات مقالات مقالات مقالات مقالات مقالات + +311 +00:25:49,830 --> 00:25:55,610 +مقالات مقالات مقالات مقالات مقالات مقالات مق هذه + +312 +00:25:55,610 --> 00:25:59,410 +منطقة مهمة جدًا ومنطقة مرتبطة في عالم السوق + +313 +00:25:59,410 --> 00:26:01,290 +التقليدي التقليدي التقليدي التقليدي التقليدي + +314 +00:26:01,290 --> 00:26:01,450 +التقليدي التقليدي التقليدي التقليدي التقليدي + +315 +00:26:01,450 --> 00:26:01,890 +التقليدي التقليدي التقليدي التقليدي التقليدي + +316 +00:26:01,890 --> 00:26:03,410 +التقليدي التقليدي التقليدي التقليدي التقليدي + +317 +00:26:03,410 --> 00:26:04,690 +التقليدي التقليدي التقليدي التقليدي التقليدي + +318 +00:26:04,690 --> 00:26:06,130 +التقليدي التقليدي التقليدي التقليدي التقليدي + +319 +00:26:06,130 --> 00:26:06,590 +التقليدي التقليدي التقليدي التقليدي التقليدي + +320 +00:26:06,590 --> 00:26:06,750 +التقليدي التقليدي التقليدي التقليدي التقليدي + +321 +00:26:06,750 --> 00:26:15,510 +التقليدي التقليدي التقليدي التقليدي التق + +322 +00:26:16,430 --> 00:26:20,570 +ممتنة في إعادة الأسهم، هذا يتجارب ممتنة وإعادة + +323 +00:26:20,570 --> 00:26:25,570 +الإعادة وفي نهاية ونهاية التجارب التجاربية هذه بعض + +324 +00:26:25,570 --> 00:26:30,730 +الدراسات التي تسجل تجارب الأسهم وما إذا كانت السوق + +325 +00:26:30,730 --> 00:26:33,750 +مفيدة أو لا إذا كانت السوق مفيدة أو لا إذا كانت + +326 +00:26:33,750 --> 00:26:36,710 +السوق مفيدة أو لا إذا كانت السوق مفيدة أو لا إذا + +327 +00:26:36,710 --> 00:26:37,650 +كانت السوق مفيدة أو لا إذا كانت السوق مفيدة أو لا + +328 +00:26:37,650 --> 00:26:38,490 +إذا كانت السوق مفيدة أو لا إذا كانت السوق مفيدة أو + +329 +00:26:38,490 --> 00:26:38,930 +لا إذا كانت السوق مفيدة أو لا إذا كانت السوق مفيدة + +330 +00:26:38,930 --> 00:26:41,830 +أو لا إذا كانت السوق مفيدة أو لا إذا كانت السوق + +331 +00:26:41,830 --> 00:26:42,410 +مفيدة أو لا + +332 +00:26:45,540 --> 00:26:50,140 +باستخدام فرصة التسويق كما أشرحت في المقال السابق + +333 +00:26:50,140 --> 00:26:55,320 +أكثر إثارة مقالية تشير إلى أن هذه الأمور اختلطت + +334 +00:26:55,320 --> 00:27:02,600 +كثيرًا بعد 2000 لماذا اختلطت؟ لأن مجموعات المؤسسات + +335 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annuity and how we + +3 +00:00:30,920 --> 00:00:34,940 +amortize loans okay today I'm going to talk about + +4 +00:00:34,940 --> 00:00:41,160 +three things first about the annuitied you okay + +5 +00:00:41,160 --> 00:00:46,980 +annuitied you and the second we'll talk about so + +6 +00:00:46,980 --> 00:00:48,040 +this is annuitied you + +7 +00:00:53,670 --> 00:01:01,010 +الثانية سنتحدث عن الانتقال والثالثة + +8 +00:01:01,010 --> 00:01:07,030 +سنتحدث عن الانتقال المشكلة المشكلة المشكلة المشكلة + +9 +00:01:07,030 --> 00:01:07,290 +المشكلة المشكلة المشكلة المشكلة المشكلة المشكلة + +10 +00:01:07,290 --> 00:01:07,290 +المشكلة المشكلة المشكلة المشكلة المشكلة المشكلة + +11 +00:01:07,290 --> 00:01:07,450 +المشكلة المشكلة المشكلة المشكلة المشكلة المشكلة + +12 +00:01:07,450 --> 00:01:08,670 +المشكلة المشكلة المشكلة المشكلة المشكلة المشكلة + +13 +00:01:08,670 --> 00:01:09,310 +المشكلة المشكلة المشكلة المشكلة المشكلة المشكلة + +14 +00:01:09,310 --> 00:01:10,030 +المشكلة المشكلة المشكلة المشكلة المشكلة المشكلة + +15 +00:01:10,030 --> 00:01:10,070 +المشكلة المشكلة المشكلة المشكلة المشكلة المشكلة + +16 +00:01:10,070 --> 00:01:18,050 +المشكلة المشكلة المش + +17 +00:01:19,190 --> 00:01:21,930 +كما قلت قبلها في المقابلة الأولى في هذا الشانتر + +18 +00:01:21,930 --> 00:01:26,330 +أتكلم عن الانعكاسين + +19 +00:01:26,330 --> 00:01:31,210 +الأول هو ordinary والثاني هو الانعكاس الواحد just + +20 +00:01:31,210 --> 00:01:35,350 +to remind you with the difference between them and + +21 +00:01:35,350 --> 00:01:42,010 +if we have this cash flow stream okay so according + +22 +00:01:42,010 --> 00:01:43,190 +to the annuity due + +23 +00:01:46,430 --> 00:01:53,390 +الدفع يأتي بدفع او اخرى في البداية من السنوات ولكن + +24 +00:01:53,390 --> 00:02:01,590 +هذا لـDue ولكن لـ Ordinary Annuity في النهاية من + +25 +00:02:01,590 --> 00:02:09,010 +السنوات فكيف تأثير هذه الحكومة على المقارنة؟ فاقوم + +26 +00:02:09,010 --> 00:02:14,850 +بالمزيد من المقارنة بـ 1 plus I 1 plus I + +27 +00:02:17,630 --> 00:02:22,230 +فاكتشف هذا بواسطة one plus I على سبيل المثال إذا + +28 +00:02:22,230 --> 00:02:27,510 +كان لديك مجموعة cash flow وكانت + +29 +00:02:27,510 --> 00:02:31,190 +مجموعة مجنوعة مجانية مجانية مجانية مجانية مجانية + +30 +00:02:31,190 --> 00:02:31,210 +مجانية مجانية مجانية مجانية مجانية مجانية مجانية + +31 +00:02:31,210 --> 00:02:31,390 +مجانية مجانية مجانية مجانية مجانية مجانية مجانية + +32 +00:02:31,390 --> 00:02:31,430 +مجانية مجانية مجانية مجانية مجانية مجانية مجانية + +33 +00:02:31,430 --> 00:02:31,890 +مجانية مجانية مجانية مجانية مجانية مجانية مجانية + +34 +00:02:31,890 --> 00:02:31,890 +مجانية مجانية مجانية مجانية مجانية مجانية مجانية + +35 +00:02:31,890 --> 00:02:37,230 +مجانية مجانية مجانية + +36 +00:02:37,230 --> 00:02:43,130 +مجانية + +37 +00:02:48,150 --> 00:02:54,270 +Okay and for the future value annuity if we talk + +38 +00:02:54,270 --> 00:03:04,290 +about future value annuity okay so Brazil value is + +39 +00:03:04,290 --> 00:03:11,810 +times by one one plus I okay raised to the power N + +40 +00:03:11,810 --> 00:03:17,630 +this is the future value for generalالآن نريد أن + +41 +00:03:17,630 --> 00:03:21,410 +نقوم بإعادة هذه المقارنة باعتبار الـ annuity و + +42 +00:03:21,410 --> 00:03:29,550 +باعتبار قيمة الوقت الحاضر اعود للأمثلة و للمواصفات + +43 +00:03:29,550 --> 00:03:35,030 +و فقط توقع النتائج بواسطة 1 plus I إذا توقعت + +44 +00:03:35,030 --> 00:03:39,070 +النتائج بواسطة 1 plus I ستحصل على annuity + +45 +00:03:43,950 --> 00:03:48,210 +ذا إذا تنظر إلى هنا قيمة المستقبلية لـ annuity هذا + +46 +00:03:48,210 --> 00:03:50,870 +لقيمة المستقبلية هي الوضع الـ payment one plus I + +47 +00:03:50,870 --> 00:03:55,610 +ريزة للقوة N مناسة واحدة مباشرة ب I مباشرة بواحدة + +48 +00:03:55,610 --> 00:03:56,630 +مباشرة ب I مباشرة بواحدة مباشرة مباشرة مباشرة + +49 +00:03:56,630 --> 00:03:57,870 +مباشرة مباشرة مباشرة مباشرة مباشرة مباشرة مباشرة + +50 +00:03:57,870 --> 00:04:00,970 +مباشرة مباشرة مباشرة مباشرة مباشرة مباشرة مباشرة + +51 +00:04:00,970 --> 00:04:01,530 +مباشرة مباشرة مباشرة مباشرة مباشرة مباشرة مباشرة + +52 +00:04:01,530 --> 00:04:01,530 +مباشرة مباشرة مباشرة مباشرة مباشرة مباشرة مباشرة + +53 +00:04:01,530 --> 00:04:05,830 +مباشرة مباشرة مباشرة + +54 +00:04:05,830 --> 00:04:08,930 +م + +55 +00:04:11,920 --> 00:04:16,960 +يجب أن نكمل هذا بالـ 1 plus I ما هو السبب خلف هذا؟ + +56 +00:04:16,960 --> 00:04:30,940 +لماذا نكمل بـ 1 plus I؟ انظر إلى هذا الطريق انظر + +57 +00:04:30,940 --> 00:04:36,320 +إلى هذا الوضع هنا هذا يبدأ بالـ 0 هو 1 2 3 إلى + +58 +00:04:36,320 --> 00:04:36,920 +Alpha + +59 +00:04:39,350 --> 00:04:45,270 +للـ ordinary annuity كما قلنا إنه يبدأ من نهاية + +60 +00:04:45,270 --> 00:04:55,630 +الوقت لذلك نحن الوقت 1 plus I ريزة لقوة N ولكن + +61 +00:04:55,630 --> 00:05:03,250 +لـ Du نحن لدينا هذا الوقت لذا يجب أن نمزج المقارنة + +62 +00:05:03,250 --> 00:05:07,530 +بـ 1 plus I لأننا لدينا هذا المقارنة لدينا واحد + +63 +00:05:07,530 --> 00:05:12,310 +سنة تبقىعلى قيمة المستقبلية و 1 سنة تبقى للقيمة + +64 +00:05:12,310 --> 00:05:18,110 +الحالية هذا هو السبب لاننا نكمل العامة بالـ 1 plus + +65 +00:05:18,110 --> 00:05:23,990 +I لأن نحن لدينا واحد فترة ليست تعتبر في النظر + +66 +00:05:23,990 --> 00:05:29,870 +العادل وفي الانعكاس العادل ولكن يجب أن نعتبر هذا + +67 +00:05:29,870 --> 00:05:33,530 +عندما نتخيل هذا على النظر الانعكاسي هذا هو السبب + +68 +00:05:33,530 --> 00:05:38,930 +لاننا نتخيل هذا على الوقت 1 plus Iو في نفس الشيء + +69 +00:05:38,930 --> 00:05:43,730 +للقيم الحاضر للقيم + +70 +00:05:43,730 --> 00:05:49,430 +الحاضر اولا المعاملات اولا المعاملات اولا مانوس + +71 +00:05:49,430 --> 00:05:51,590 +واحد واحد اكتر اكتر اكتر اكتر اكتر اكتر اكتر اكتر + +72 +00:05:51,590 --> 00:05:52,470 +اكتر اكتر اكتر اكتر اكتر اكتر اكتر اكتر اكتر اكتر + +73 +00:05:52,470 --> 00:05:54,550 +اكتر اكتر اكتر اكتر اكتر اكتر اكتر اكتر اكتر اكتر + +74 +00:05:54,550 --> 00:05:54,990 +اكتر اكتر اكتر اكتر اكتر اكتر اكتر اكتر اكتر اكتر + +75 +00:05:54,990 --> 00:06:02,890 +اكتر اكتر اكتر اكتر اكتر اكتر ا + +76 +00:06:08,310 --> 00:06:12,870 +هذه هي الفكرة أو الفرق بين الـ annuity due و + +77 +00:06:12,870 --> 00:06:18,450 +ordinary annuity اعود + +78 +00:06:18,450 --> 00:06:24,410 +للأمثلة أو تجارب المثال مرة أخرى انظر للأمثلة مرة + +79 +00:06:24,410 --> 00:06:28,070 +أخرى وانظر إلى أين اتخذنا قيمة المستقبل لعام 10 + +80 +00:06:28,070 --> 00:06:37,330 +عام عشان 3000$ يعني 5% يكون 37734 + +81 +00:06:37,330 --> 00:06:41,640 +$يجب أن تطبق هذه المقارنة لتخطيط الـ value التي + +82 +00:06:41,640 --> 00:06:46,440 +قمت بها، لذلك الـ payments مرة واحدة أكتر من I + +83 +00:06:46,440 --> 00:06:57,120 +مقارنة ب I و بعد هذا واحدة أكتر من I تحاول ان تقوم + +84 +00:06:57,120 --> 00:07:02,280 +بالتخطيط بنفسك لتر الاختلاع بين هذا والأخر + +85 +00:07:07,020 --> 00:07:13,000 +Apply this equation okay Apply + +86 +00:07:13,000 --> 00:07:20,080 +this equation okay So what is the payment? 3000 + +87 +00:07:20,080 --> 00:07:31,740 +one plus I I is five percent or O five raised to + +88 +00:07:31,740 --> 00:07:47,810 +the power ten-1 ÷ I هو 0.5 ثم الوقت 1 plus 0.5 39 + +89 +00:07:47,810 --> 00:07:52,810 +,620 + +90 +00:07:52,810 --> 00:07:58,790 +ما رأيك؟ أفضل + +91 +00:07:58,790 --> 00:08:00,050 +جدًا للمستخدمين + +92 +00:08:02,640 --> 00:08:08,300 +and you with the due or the or + +93 +00:08:08,300 --> 00:08:11,900 +ordinary okay go back to the ordinary or calculate + +94 +00:08:11,900 --> 00:08:21,920 +the space on the ordinary and see the results the + +95 +00:08:21,920 --> 00:08:27,640 +ordinary due yeah because you have moreyes cash + +96 +00:08:27,640 --> 00:08:31,680 +flows or you get benefit more in this but it + +97 +00:08:31,680 --> 00:08:36,480 +depends on you as investors when you get the cash + +98 +00:08:36,480 --> 00:08:45,520 +flow or when you deposit the cash flow okay and + +99 +00:08:45,520 --> 00:08:51,380 +you can do it in excel okay + +100 +00:08:56,570 --> 00:09:12,270 +go to the excel okay + +101 +00:09:12,270 --> 00:09:20,030 +in + +102 +00:09:20,030 --> 00:09:23,990 +excel we have payments + +103 +00:09:25,920 --> 00:09:36,080 +we have I و we have M and we want to calculate the + +104 +00:09:36,080 --> 00:09:40,660 +future value okay so what is the payment three + +105 +00:09:40,660 --> 00:09:51,520 +thousand okay let's see to see okay I five percent + +106 +00:09:53,710 --> 00:09:57,550 +ن هي تن و الأن نريد أن نتخيل قيمة المستقبل لذلك + +107 +00:09:57,550 --> 00:10:04,210 +قيمة المستقبل هي مثل هذا و انا قيمة المستقبل قيمة + +108 +00:10:04,210 --> 00:10:16,430 +المستقبل ريز هو 5% ثم الواجب هو 3000 ثم + +109 +00:10:16,430 --> 00:10:18,150 +قيمة الوضع هو + +110 +00:10:23,940 --> 00:10:32,720 +Sorry؟ We want the payments. Okay, we have .. + +111 +00:10:32,720 --> 00:10:36,080 +Okay, we need the payments. The payment is three + +112 +00:10:36,080 --> 00:10:42,540 +thousand and the type here is important. If you + +113 +00:10:42,540 --> 00:10:43,100 +put zero + +114 +00:10:49,160 --> 00:10:52,100 +العامة كم مرات؟ + +115 +00:11:15,390 --> 00:11:21,610 +لنعود و تلت تلت تلت تلت تلت تلت تلت تلت تلت تلت + +116 +00:11:21,610 --> 00:11:26,890 +تلت تلت تلت تلت تلت تلت تلت تلت تلت + +117 +00:11:26,890 --> 00:11:28,050 +تلت تلت تلت تلت تلت تلت تلت تلت تلت تلت تلت تلت + +118 +00:11:28,050 --> 00:11:28,050 +تلت تلت تلت تلت تلت تلت تلت تلت تلت تلت تلت تلت + +119 +00:11:28,050 --> 00:11:28,050 +تلت تلت تلت تلت تلت تلت تلت تلت تلت تلت تلت تلت + +120 +00:11:28,050 --> 00:11:28,070 +تلت تلت تلت تلت تلت تلت تلت تلت تلت تلت تلت تلت + +121 +00:11:28,070 --> 00:11:28,070 +تلت تلت تلت تلت تلت تلت + +122 +00:11:44,010 --> 00:11:53,290 +الدفعات 3000 والنسبة هي إذا وضعت زرع وإذا وضعت + +123 +00:11:53,290 --> 00:11:57,530 +واحد فهي مختلفة فانتج الفرصة الآن + +124 +00:12:14,520 --> 00:12:21,460 +الأن اعود للإيقاع هنا إذا كنت تلاعب في الوقت نحن + +125 +00:12:21,460 --> 00:12:28,440 +نحضر واحدة وانها عادية وإذا كنت تقرأ هذا وإذا كنت + +126 +00:12:28,440 --> 00:12:32,460 +تحضر زرع فانت + +127 +00:12:32,460 --> 00:12:36,800 +تحضر عادية فانت + +128 +00:12:36,800 --> 00:12:44,120 +ترى الفرصة الأن فانت تحضر ثلاث سبع ألفOkay so this + +129 +00:12:44,120 --> 00:12:49,200 +is the difference between the annuity due and the + +130 +00:12:49,200 --> 00:12:52,920 +ordinary okay + +131 +00:12:52,920 --> 00:12:58,080 +and the difference is worth we will see we will + +132 +00:12:58,080 --> 00:13:04,400 +calculate this based + +133 +00:13:04,400 --> 00:13:09,540 +on the annuity and one based on the ordinary due + +134 +00:13:09,540 --> 00:13:12,200 +and to find the difference between them + +135 +00:13:35,740 --> 00:13:40,600 +سنقوم باستخدام مقارنة المقارنة باستخدام مقارنة الـ + +136 +00:13:40,600 --> 00:13:46,800 +Annuated U و سنرى الفرصة الموجودة في المقارنة + +137 +00:13:46,800 --> 00:13:48,480 +الموجودة في المقارنة الموجودة في المقارنة الموجودة + +138 +00:13:48,480 --> 00:13:49,080 +في المقارنة الموجودة في المقارنة الموجودة في + +139 +00:13:49,080 --> 00:13:51,600 +المقارنة الموجودة في المقارنة الموجودة في المقارنة + +140 +00:13:51,600 --> 00:13:53,320 +الموجودة في المقارنة الموجودة في المقارنة الموجودة + +141 +00:13:53,320 --> 00:13:53,320 +في المقارنة الموجودة في المقارنة الموجودة في + +142 +00:13:53,320 --> 00:13:53,320 +المقارنة الموجودة في المقارنة الموجودة في المقارنة + +143 +00:13:53,320 --> 00:13:53,340 +الموجودة في المقارنة الموجودة في المقارنة الموجودة + +144 +00:13:53,340 --> 00:14:04,780 +في المقار + +145 +00:14:12,080 --> 00:14:15,000 +1886 what do you think this difference why this + +146 +00:14:15,000 --> 00:14:19,060 +difference from where this difference is coming it + +147 +00:14:19,060 --> 00:14:25,780 +means + +148 +00:14:25,780 --> 00:14:29,740 +you have more cash flow means more one year cash + +149 +00:14:29,740 --> 00:14:33,080 +flow or the difference is in calculating the + +150 +00:14:33,080 --> 00:14:33,460 +interest + +151 +00:14:43,130 --> 00:14:47,110 +more period it means more cash flows or more + +152 +00:14:47,110 --> 00:14:58,330 +interest it means + +153 +00:14:58,330 --> 00:15:03,670 +we add a new year or a new cash flowأو قيمة جديدة + +154 +00:15:03,670 --> 00:15:07,390 +لأن + +155 +00:15:07,390 --> 00:15:15,890 +القيمة تتجمد و نضع قيمة واحدة أكتر من السنة و ليس + +156 +00:15:15,890 --> 00:15:22,070 +كاشفلو لأن الكاشفلو مقفل ولكن إذا كنت تنظر إلى هنا + +157 +00:15:22,070 --> 00:15:25,450 +على سبيل المثال فقط لثلاث سنوات إذا كان لدينا واحد + +158 +00:15:25,450 --> 00:15:30,760 +اثنان ثلاثانظروا إلى الفرق، وهو يبدأ بالزيرو، وهذا + +159 +00:15:30,760 --> 00:15:35,860 +هو الزيرو، وهذا هو واحد، وهذا هو بداية العام، وهذا + +160 +00:15:35,860 --> 00:15:40,820 +هو نهاية العام، وهذا هو بداية العام، وهذا هو نهاية + +161 +00:15:40,820 --> 00:15:44,200 +العام، وهذا هو نفس الشيء، لذلك إذا كانت المال يأتي + +162 +00:15:44,200 --> 00:15:46,900 +من هنا، ستستخدم هذه المالية لعامين + +163 +00:15:49,570 --> 00:15:55,850 +فانت فقط تستثمر لهذه الانتصارين وانت تستثمر لهذه + +164 +00:15:55,850 --> 00:15:57,310 +الانتصارين وانت تستثمر لهذه الانتصارين وانت تستثمر + +165 +00:15:57,310 --> 00:15:57,790 +لهذه الانتصارين وانت تستثمر لهذه الانتصارين وانت + +166 +00:15:57,790 --> 00:15:58,050 +تستثمر لهذه الانتصارين وانت تستثمر لهذه الانتصارين + +167 +00:15:58,050 --> 00:15:58,070 +وانت تستثمر لهذه الانتصارين وانت تستثمر لهذه + +168 +00:15:58,070 --> 00:16:01,630 +الانتصارين وانت تستثمر لهذه الانتصارين وانت تستثمر + +169 +00:16:01,630 --> 00:16:04,710 +لهذه الانتصارين وانت تستثمر لهذه الانتصارين وانت + +170 +00:16:04,710 --> 00:16:09,070 +تستثمر لهذه الانتصارين وانت تستثمر لهذه الانتصارين + +171 +00:16:09,070 --> 00:16:10,670 +وانت تستثمر لهذه الانت + +172 +00:16:14,500 --> 00:16:24,440 +والثاني هو one year + +173 +00:16:24,440 --> 00:16:29,880 +والثالث هو zero انظر + +174 +00:16:29,880 --> 00:16:34,380 +إلى الانتقال + +175 +00:16:34,380 --> 00:16:37,400 +الواسع الواسع الواسع الواسع الواسع الواسع الواسع + +176 +00:16:37,400 --> 00:16:37,400 +الواسع الواسع الواسع الواسع الواسع الواسع الواسع + +177 +00:16:37,400 --> 00:16:37,420 +الواسع الواسع الواسع الواسع الواسع الواسع الواسع + +178 +00:16:37,420 --> 00:16:40,720 +الواسع الواسع الواسع الواسع الواسع الواسع الواسع + +179 +00:16:40,720 --> 00:16:40,720 +الواسع الواسع الواسع الواسع الواسع الواسع الواسع + +180 +00:16:40,720 --> 00:16:40,720 +الواسع الواسع الواسع الواسع الواسع الواسع الواسع + +181 +00:16:40,720 --> 00:16:40,720 +الواسع الواسع الواسع الواسع الواسع الواسع الواسع + +182 +00:16:40,720 --> 00:16:40,720 +الواسع + +183 +00:16:43,820 --> 00:16:55,460 +ثم هذه 2 سنة و هذه 1 سنة لأنك + +184 +00:16:55,460 --> 00:16:59,220 +لديك أكتر فرصة لكي تستخدم المال لكي تستخدم المال + +185 +00:16:59,220 --> 00:17:05,080 +لكي تستخدم المال لكي تستخدم المال لكي تستخدم المال + +186 +00:17:05,080 --> 00:17:10,240 +لكي تستخدم المال لكي تستخدم المال لكي تستخدم + +187 +00:17:17,590 --> 00:17:18,250 +any question? + +188 +00:17:21,650 --> 00:17:27,490 +so try to recall the questions and do the same + +189 +00:17:33,980 --> 00:17:37,100 +تذكر الـ Checkpoint 6.2 البرنامج Check Yourself + +190 +00:17:37,100 --> 00:17:41,280 +حيث قمنا بتقيم قيمة الوقت لـ 10 سنة عامة عامة عامة + +191 +00:17:41,280 --> 00:17:43,980 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +192 +00:17:43,980 --> 00:17:45,800 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +193 +00:17:45,800 --> 00:17:46,600 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +194 +00:17:46,600 --> 00:17:48,960 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +195 +00:17:48,960 --> 00:17:51,500 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +196 +00:17:51,500 --> 00:18:02,160 +عامة عامة عامة عامة عامة عامة عامة عامة عام + +197 +00:18:03,510 --> 00:18:08,270 +العامة الحاضره هي عامة عامة عامة عامة عامة عامة + +198 +00:18:08,270 --> 00:18:15,070 +عامة عامة عامة عامة عامة + +199 +00:18:16,220 --> 00:18:22,000 +-1 ÷ 1 plus I raised to the power N okay divided + +200 +00:18:22,000 --> 00:18:27,060 +by I but don't forget to multiply this by 1 plus I + +201 +00:18:27,060 --> 00:18:30,300 +I'm + +202 +00:18:30,300 --> 00:18:36,350 +talking about this is a U with a Uالسؤال هو الـ + +203 +00:18:36,350 --> 00:18:39,030 +Annuated U's، حسنًا، تذكر الـ Checkpoint، تحقق + +204 +00:18:39,030 --> 00:18:42,670 +نفسك مشكلة حيث قمنا بتخصيص قيمة الحضارة، قيمة + +205 +00:18:42,670 --> 00:18:47,450 +الحضارة لكي تكون مثل هذه، لذلك نريد أن نتخصص قيمة + +206 +00:18:47,450 --> 00:18:51,930 +الـ Annuated U، لكنه يتم تخصيصه باستخدام قيمة + +207 +00:18:51,930 --> 00:18:56,210 +الحضارة Annuated، يتم تخصيصه، لذلك الآن فقط تجهز + +208 +00:18:56,210 --> 00:19:01,510 +هذا المثال أو هذه المقالة واضع قيمة الـ Annuated + +209 +00:19:01,510 --> 00:19:02,870 +U، + +210 +00:19:04,820 --> 00:19:10,540 +انظر إلى ما سيكون قيمة الـ $ 10,000 في البداية من + +211 +00:19:10,540 --> 00:19:16,440 +كل عام لإنقاذك، على سبيل المثال، كانت المالات + +212 +00:19:16,440 --> 00:19:23,620 +انقذتك، لذلك في هذه الحالة، انقذتك وتحاول ان تفعل + +213 +00:19:23,620 --> 00:19:29,200 +التخطيطات هنا قيمة الـ $ 10,000 + +214 +00:19:31,480 --> 00:19:40,600 +one minus one one plus I I is point ten point ten + +215 +00:19:40,600 --> 00:19:48,980 +raised to the power ten divided by point ten and + +216 +00:19:48,980 --> 00:19:55,160 +here one plus point ten okay so do the + +217 +00:19:55,160 --> 00:20:05,170 +calculations and let's seeشكرا لك لإكسل لعمل هذا + +218 +00:20:05,170 --> 00:20:13,770 +العمل جيدا و أصحاب الانترنت يستمتعون بإكسل + +219 +00:20:13,770 --> 00:20:21,810 +الانترنت او + +220 +00:20:21,810 --> 00:20:22,570 +الانترنت او الانترنت او الانترنت او الانترنت + +221 +00:20:29,680 --> 00:20:36,760 +و I هو 10% و + +222 +00:20:36,760 --> 00:20:56,500 +N هو 10 و الأن نريد أن نتخيل قيمة الوقت لذلك + +223 +00:20:56,500 --> 00:20:56,880 +قيمة الوقت + +224 +00:21:05,070 --> 00:21:12,550 +سوف اذهب الى الـ is equal present value او + +225 +00:21:12,550 --> 00:21:27,610 +اذهب الى ال .. السعر هو 10% رقم السفر هو 10 رقم + +226 +00:21:27,610 --> 00:21:30,430 +السفر هو 10 ألف و الأن + +227 +00:21:33,750 --> 00:21:37,970 +هذا الوقت زرعه او واحد اذا واحد + +228 +00:24:40,110 --> 00:24:48,750 +from the discount rate okay is it clear this yes + +229 +00:24:48,750 --> 00:24:55,830 +make your mind up try to think okay + +230 +00:24:55,830 --> 00:24:59,150 +it + +231 +00:24:59,150 --> 00:25:02,730 +means in other words we save one year from the + +232 +00:25:02,730 --> 00:25:06,310 +discounted we are not discounted one year one + +233 +00:25:06,310 --> 00:25:10,630 +thousand is one thousand but in the ordinarythis + +234 +00:25:10,630 --> 00:25:13,690 +is is discounted the first payment is discounted + +235 +00:25:13,690 --> 00:25:20,250 +again this is why the payments or the present + +236 +00:25:20,250 --> 00:25:25,190 +value in the ordinary sorry in the annuitied you + +237 +00:25:25,190 --> 00:25:29,210 +is greater than the present value in the ordinary + +238 +00:25:29,210 --> 00:25:35,170 +okay there + +239 +00:25:35,170 --> 00:25:41,280 +are pet pettiesso this is the second things that I + +240 +00:25:41,280 --> 00:25:46,640 +will talk about what it means perpetuity okay what + +241 +00:25:46,640 --> 00:25:51,960 +it means perpetuity in any language in Hindu, in + +242 +00:25:51,960 --> 00:25:56,180 +Dutch it's like any maturity but it has no + +243 +00:25:56,180 --> 00:25:59,700 +maturity no maturity okay can you give example of + +244 +00:25:59,700 --> 00:26:05,240 +this you are right وقف yes + +245 +00:26:05,240 --> 00:26:11,780 +وقفوقف for instance in the Muslim countries we + +246 +00:26:11,780 --> 00:26:18,980 +have things known as الوقف وقف okay أرض وقف أو + +247 +00:26:18,980 --> 00:26:24,760 +ممكن it's not necessary to be وقف maybe + +248 +00:26:24,760 --> 00:26:29,120 +some you know some charity organizations they + +249 +00:26:29,120 --> 00:26:35,040 +invest they invest their money and they state this + +250 +00:26:35,040 --> 00:26:36,560 +investment for + +251 +00:26:39,400 --> 00:26:43,600 +unlimited period of time or forever، this is on + +252 +00:26:43,600 --> 00:26:47,320 +forever، this business is on forever like the + +253 +00:26:47,320 --> 00:26:51,930 +charity organizationفي البلدان المسلمة، نحن نعرف + +254 +00:26:51,930 --> 00:26:55,810 +شيء في الوخف، وفي المسلمين، يعرفون الـ trash + +255 +00:26:55,810 --> 00:26:59,930 +يمتلون مبادئهم، وهذه المبادئ تدفع مهاجمات الـ + +256 +00:26:59,930 --> 00:27:07,330 +trash، فهذا معروف كالتعذيب التعذيب التعذيبي + +257 +00:27:07,330 --> 00:27:10,610 +التعذيبي + +258 +00:27:10,610 --> 00:27:13,030 +التعذيبي التعذيبي التعذيبي التعذيبي التعذيبي + +259 +00:27:13,030 --> 00:27:13,630 +التعذيبي التعذيبي التعذيبي التعذيبي التعذيبي + +260 +00:27:13,630 --> 00:27:14,230 +التعذيبي التعذيبي التعذيبي التعذيبي التعذيبي + +261 +00:27:14,230 --> 00:27:14,230 +التعذيبي التعذيبي التعذيبي التعذيبي التعذيبي + +262 +00:27:14,230 --> 00:27:16,370 +التعذيبي التعذيبي التعذيبي التعذيبي التعذيبي التع + +263 +00:27:17,680 --> 00:27:24,240 +هذه السلامة ، لذلك هذه السلامة تستغرق مؤسسات أو + +264 +00:27:24,240 --> 00:27:34,080 +مؤسسات الحكومة لفترة غير محدودة لإستمرار مهم + +265 +00:27:34,080 --> 00:27:38,980 +للحكومة مهم للشركات المشتركة مهم للعديد من + +266 +00:27:38,980 --> 00:27:49,350 +المسلسلين لتأكيد نطاق المال لعملاتهمOkay, this is + +267 +00:27:49,350 --> 00:27:54,510 +why it's called perpetuity because unlimited Okay, + +268 +00:27:54,870 --> 00:28:01,010 +and you cannot liquidate this to cash, into cash + +269 +00:28:01,010 --> 00:28:05,470 +Another example here, the IUG, Islamic University + +270 +00:28:05,470 --> 00:28:10,290 +of Gaza, they offer the investments or invest in + +271 +00:28:10,290 --> 00:28:15,510 +something looks like the perpetuityأجهزة جديدة + +272 +00:28:15,510 --> 00:28:22,010 +وانبعاث جديد لدفع المدرسات السيئة لذلك ال .. ال .. + +273 +00:28:22,010 --> 00:28:24,090 +ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال + +274 +00:28:24,090 --> 00:28:26,290 +.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. + +275 +00:28:26,290 --> 00:28:26,290 +ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال + +276 +00:28:26,290 --> 00:28:27,010 +.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. + +277 +00:28:27,010 --> 00:28:27,350 +ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال + +278 +00:28:27,350 --> 00:28:27,970 +.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. + +279 +00:28:27,970 --> 00:28:30,030 +ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال + +280 +00:28:30,030 --> 00:28:30,030 +.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. + +281 +00:28:30,030 --> 00:28:30,230 +ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال + +282 +00:28:30,230 --> 00:28:30,230 +.. ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. + +283 +00:28:30,230 --> 00:28:36,990 +ال .. ال .. ال .. ال .. ال .. ال .. ال .. ال .. + +284 +00:28:36,990 --> 00:28:38,870 +ال + +285 +00:28:45,620 --> 00:28:51,760 +لأهداف محددة ولأشياء محددة نحن + +286 +00:28:51,760 --> 00:28:55,360 +لدينا أربع مرات من الـ Perpetuity نحن لدينا مستوى + +287 +00:28:55,360 --> 00:29:01,300 +Perpetuity ونحن لدينا مستوى Growth Perpetuity وهو + +288 +00:29:01,300 --> 00:29:04,980 +بسيط جدا لتحسين هذا هو بسيط جدا بسيط جدا ال + +289 +00:29:04,980 --> 00:29:09,260 +Perpetuity هي مبادرة تستمر دائما أو ليس لديها + +290 +00:29:09,260 --> 00:29:13,240 +مدرسة على سبيل المثال مجموعة دفع على شركة أفضل + +291 +00:29:13,240 --> 00:29:17,890 +السوقهناك اتجارات عامة من الانتقال الانتقال + +292 +00:29:17,890 --> 00:29:25,350 +الانتقال الانتقال يبدو مثل هذا على سبيل المثال بعد + +293 +00:29:25,350 --> 00:29:32,530 +خمس سنوات هذا الانتقال يزداد يزداد كل خمس سنوات + +294 +00:29:32,530 --> 00:29:38,530 +ويبدو مثل هذا كل + +295 +00:29:38,530 --> 00:29:41,930 +مرة محددة يزداد + +296 +00:29:44,510 --> 00:29:48,950 +مثلًا مرة أخرى، إذا كانوا يحصلوا على أرباح، إذا + +297 +00:29:48,950 --> 00:29:53,130 +كانوا يصنعوا أرباح، فإنهم يحفظوا هذه الأرباح أو + +298 +00:29:53,130 --> 00:29:58,130 +يحفظوا هذه الأرباح ويقوموا بـ Growth ويقوموا بـ + +299 +00:29:58,130 --> 00:30:05,810 +Expansion ويبدو مثل هذا، ولكن مستمرية المستوى يبدو + +300 +00:30:05,810 --> 00:30:12,570 +مثل هذا، مقفلة، مجموعة المال مقفلة، لا تغير + +301 +00:30:19,330 --> 00:30:22,950 +in the .. in Gaza we have many examples of + +302 +00:30:22,950 --> 00:30:27,910 +perpetuity funds مثلا بساتين street شوفوا شارع + +303 +00:30:27,910 --> 00:30:34,170 +البساتين هذا للوقف وهذا إلى مال نهاية بياخدوا + +304 +00:30:34,170 --> 00:30:40,550 +إيجار من ال .. من المنتفعين لمصلحة الوزارة الأوقاف + +305 +00:30:40,550 --> 00:30:45,930 +فكرة ال .. ال perpetuity is another for alpha ال + +306 +00:30:45,930 --> 00:30:52,300 +cash flowالأولى لـ Alpha فهي غير محدودة فالتنمية + +307 +00:30:52,300 --> 00:31:00,580 +التنمية هي أن هذا الشركة تنمو خلال ثلاث سنوات أو + +308 +00:31:00,580 --> 00:31:07,740 +خلال خمس سنوات أو مهما تنمو تنمو تنمو تنمو تنمو + +309 +00:31:07,740 --> 00:31:09,800 +تنمو تنمو تنمو تنمو تنمو تنمو تنمو تنمو تنمو تنمو + +310 +00:31:09,800 --> 00:31:09,800 +تنمو تنمو تنمو تنمو تنمو تنمو تنمو تنمو تنمو تنمو + +311 +00:31:09,800 --> 00:31:09,920 +تنمو تنمو تنمو تنمو تنمو تنمو تنمو تنمو تنمو تنمو + +312 +00:31:09,920 --> 00:31:15,500 +تنمو تنمو تنمو تنمو تنمو تن + +313 +00:31:16,580 --> 00:31:21,600 +the payment is the payment the cash flow and I is + +314 +00:31:21,600 --> 00:31:25,440 +interest rate or the income rate or the مضاربة + +315 +00:31:25,440 --> 00:31:30,380 +rate or whatever okay any rate I recommend you to + +316 +00:31:30,380 --> 00:31:33,100 +to read about financial islamic financial + +317 +00:31:33,100 --> 00:31:38,520 +transactions okay this is important انا باخد + +318 +00:31:38,520 --> 00:31:40,660 +course هلأ بال .. بال .. بال islamic financial + +319 +00:31:40,660 --> 00:31:47,930 +transactions عساس ا see اهأه, so this is important + +320 +00:31:47,930 --> 00:31:51,110 +because it's important to include the Islamic + +321 +00:31:51,110 --> 00:31:56,650 +financial securities in financial management okay + +322 +00:31:56,650 --> 00:32:02,930 +two weeks ago, London issued the first Islamic + +323 +00:32:02,930 --> 00:32:09,310 +sukuk in London which cost him 200 million dollar + +324 +00:32:09,310 --> 00:32:15,020 +and they issued the financial Islamic indexهذه قبل + +325 +00:32:15,020 --> 00:32:20,700 +أسبوعين، طبعاً كيف نقوم بتخطيط هذا، قيمة الحصول + +326 +00:32:20,700 --> 00:32:23,020 +على مستوى مستوى مستوى مستوى مستوى مستوى مستوى + +327 +00:32:23,020 --> 00:32:25,660 +مستوى مستوى مستوى + +328 +00:32:27,360 --> 00:32:31,180 +بقيمة 7% تقريبًا، فقيمة الـ present value هي + +329 +00:32:31,180 --> 00:32:33,440 +تقريبًا الـ payment تقريبًا من I، فتقريبًا 600 + +330 +00:32:33,440 --> 00:32:39,560 +تقريبًا من 7، تقريبًا 8000، ولكن إذا كان لدينا + +331 +00:32:39,560 --> 00:32:44,560 +تقريبات فتقريبًا I minus J، فتقريبًا I minus J، + +332 +00:32:44,560 --> 00:32:50,540 +وهذا يذكرك بمحافظة الأسهم، كيف تتخيل قيمة المحافظة + +333 +00:32:50,540 --> 00:32:54,540 +الأسهم في الاستثمار. فقيمة ال present of level + +334 +00:32:54,540 --> 00:32:58,650 +perpetuity، ما هي قيمة ال present؟مستمرًا من 500 + +335 +00:32:58,650 --> 00:33:04,110 +دفعات عامًا تدفع إلى الـ 8% الموجود فقط قطع 500 من + +336 +00:33:04,110 --> 00:33:12,870 +8% فهذا 500 من 8% وهو نفس الشيء ما هو قيمة الـ + +337 +00:33:12,870 --> 00:33:18,890 +Stream Payments مميزة لـ 90,000 دفعات عامًا 90,000 + +338 +00:33:18,890 --> 00:33:30,510 +من 9% فهو نفس الشيءللمزيد من الوقت، في المزيد من + +339 +00:33:30,510 --> 00:33:33,130 +الوقت اللي يزال المال يزال يزال يزال يزال يزال + +340 +00:33:33,130 --> 00:33:35,070 +يزال يزال يزال يزال يزال يزال يزال يزال يزال يزال + +341 +00:33:35,070 --> 00:33:35,070 +يزال يزال يزال يزال يزال يزال يزال يزال يزال يزال + +342 +00:33:35,070 --> 00:33:35,230 +يزال يزال يزال يزال يزال يزال يزال يزال يزال يزال + +343 +00:33:35,230 --> 00:33:35,230 +يزال يزال يزال يزال يزال يزال يزال يزال يزال يزال + +344 +00:33:35,230 --> 00:33:38,470 +يزال يزال يزال يزال يزال يزال يزال يزال يزال يزال + +345 +00:33:38,470 --> 00:33:42,430 +يزال يزال يزال يزال يزال يزال يزال يزال يزال يزال + +346 +00:33:42,430 --> 00:33:45,330 +يزال يز + +347 +00:33:47,500 --> 00:33:51,400 +ماذا هو قيمة البرازن بين مجموعات المال الذي يدفع + +348 +00:33:51,400 --> 00:33:55,640 +500 دولار في نهاية السنة واحدة ولكنها تنزل في قيمة + +349 +00:33:55,640 --> 00:34:01,380 +4% في كل عام باستخدام قيمة الانترنت التي تستخدمها + +350 +00:34:01,380 --> 00:34:11,920 +لتخلص المال هي 8% ف500 مق 8% مق 4% فهذا + +351 +00:34:11,920 --> 00:34:17,600 +هو الإجابة ترى الإجابة هناالان مباركات المال + +352 +00:34:17,600 --> 00:34:24,300 +المشكلة المشكلة + +353 +00:34:24,300 --> 00:34:26,520 +المشكلة المشكلة المشكلة المشكلة المشكلة المشكلة + +354 +00:34:26,520 --> 00:34:26,880 +المشكلة المشكلة المشكلة المشكلة المشكلة المشكلة + +355 +00:34:26,880 --> 00:34:37,120 +المشكلة المشكلة المشكلة + +356 +00:34:37,120 --> 00:34:42,500 +المشكلة المشكلة المشكلة المشكلة المشكلة المشكلة + +357 +00:34:42,500 --> 00:34:42,660 +المشكلة المشكلة المشكلة المشكلة المشكلة المشكلة + +358 +00:34:42,660 --> 00:34:42,660 +المشكلة المشكلة المشكلة المشكلة المشكلة المشكلة + +359 +00:34:42,660 --> 00:34:42,660 +المشكلة المشكلة المشكلة المشكلة المشكلة المشكلة + +360 +00:34:42,660 --> 00:34:42,660 +المشكلة المشكلة المشكلة المشكلة المشكلة المشكلة + +361 +00:34:42,660 --> 00:34:42,740 +المشكلة المشكلة المشكلة المشكلة المشكلة المشكلة + +362 +00:34:42,740 --> 00:34:42,880 +المشكل + +363 +00:34:46,670 --> 00:34:50,570 +مجموعة المال يأتي من خلال عقد غير عادل تعتبر هذه + +364 +00:34:50,570 --> 00:34:54,070 +الحالة حسنًا + +365 +00:34:54,070 --> 00:35:02,890 +لدينا هنا ألف دولار وحسنًا لدينا ألف واثنين واثنين + +366 +00:35:02,890 --> 00:35:07,310 +واثنين واثنين واثنين واثنين واثنين واثنين واثنين + +367 +00:35:07,310 --> 00:35:07,310 +واثنين واثنين واثنين واثنين واثنين واثنين واثنين + +368 +00:35:07,310 --> 00:35:07,370 +واثنين واثنين واثنين واثنين واثنين واثنين واثنين + +369 +00:35:07,370 --> 00:35:09,850 +واثنين واطنين واطنين واطنين واطنين واطنين واطنين + +370 +00:35:09,850 --> 00:35:12,690 +واطنين واطنين واطنين واطنين واطنين واطنين واطنإذا + +371 +00:35:12,690 --> 00:35:16,050 +أردنا نخطط قيمة الوقت من هذا، لا يمكننا أن نطبق + +372 +00:35:16,050 --> 00:35:24,950 +قيمة الوقت أو قيمة المستقبل لأننا لدينا .. بالحظ، + +373 +00:35:24,950 --> 00:35:32,130 +و هذا جيد لكم في هذه القصة لأن هذه القصة هي لأطفال + +374 +00:35:32,130 --> 00:35:32,650 +المدرسة + +375 +00:35:35,990 --> 00:35:41,790 +هذا مشكلة بسيطة جدا ولكن في الـ Complex Cash Flows + +376 +00:35:41,790 --> 00:35:46,950 +لدينا بعض القيامة كيف نستخدمها لكي نكون عامة أو + +377 +00:35:46,950 --> 00:35:50,050 +عامة على سبيل المثال، انظر لهذا، ما يمكننا أن + +378 +00:35:50,050 --> 00:35:57,430 +نفعله، نفعله مثل هذا ألف و ألف و نحن لدينا ألف هنا + +379 +00:35:57,430 --> 00:36:06,160 +و ألف هنا، إنه نفس الشيءفهذا مقيم 2000 مقيم 1000 + +380 +00:36:06,160 --> 00:36:13,900 +مقيم 1000 فهنا نحن لدينا نسخة عادية وهنا نحن لدينا + +381 +00:36:13,900 --> 00:36:17,320 +نسخة عادية تأتي هنا ونسخة عادية تأتي في النهاية + +382 +00:36:17,320 --> 00:36:24,360 +لذلك بدلا من استخدام هذه التقنيات فنحن فقط في + +383 +00:36:24,360 --> 00:36:30,300 +اتصالين اثنين نخلص هذا المشكلة حسنا؟ تعتبر هذه + +384 +00:36:30,300 --> 00:36:30,360 +الحالة + +385 +00:36:41,040 --> 00:36:45,480 +احد اثنين اثنين + +386 +00:36:45,480 --> 00:36:51,160 +اثنين اثنين اثنين اثنين اثنين اثنين اثنين اثنين + +387 +00:36:51,160 --> 00:36:51,160 +اثنين اثنين اثنين اثنين اثنين اثنين اثنين اثنين + +388 +00:36:51,160 --> 00:36:51,260 +اثنين اثنين اثنين اثنين اثنين اثنين اثنين اثنين + +389 +00:36:51,260 --> 00:36:52,580 +اثنين اثنين اثنين اثنين اثنين اثنين اثنين اثنين + +390 +00:36:52,580 --> 00:36:52,660 +اثنين اثنين اثنين اثنين اثنين اثنين اثنين اثنين + +391 +00:36:52,660 --> 00:36:53,760 +اثنين اثنين اثنين اثنين اثنين اثنين اثنين اثنين + +392 +00:36:53,760 --> 00:37:06,300 +اثنين اثنين اثنين اثنين اثنين اث + +393 +00:37:07,210 --> 00:37:11,370 +1 plus I raised to the power 2 and this is 1 plus + +394 +00:37:11,370 --> 00:37:14,950 +I raised to the power 3 if we want to calculate + +395 +00:37:14,950 --> 00:37:21,690 +the present value and we have the sum of these but + +396 +00:37:21,690 --> 00:37:25,950 +other people they may use different techniques + +397 +00:37:25,950 --> 00:37:33,970 +okay this is you can calculate this four thousands + +398 +00:37:33,970 --> 00:37:41,300 +this is looks like annuityوانت ممكن تخلص من خلاص + +399 +00:37:41,300 --> 00:37:47,580 +من هذا الواحد لذا يمكننا أن نستخدم او هذه تقنية + +400 +00:37:47,580 --> 00:37:52,960 +واحدة يمكنك استخدام تقنية أخرى حسنا هذه 2000 2000 + +401 +00:37:52,960 --> 00:38:00,060 +2000 هل هذا صح؟ وهنا 2000 2000بإمكاننا تخلص من هذا + +402 +00:38:00,060 --> 00:38:07,440 +باستخدام تخطيط هذه المالية كمجال وهذه كمجال في + +403 +00:38:07,440 --> 00:38:14,740 +نهاية اليوم باستخدام هذا أو هذا ستجد نفس النتائج + +404 +00:38:14,740 --> 00:38:21,640 +هذا بسيط جدا دعونا نذهب إلى + +405 +00:38:24,480 --> 00:38:27,000 +or the idea of the complex. So the cash flows + +406 +00:38:27,000 --> 00:38:29,360 +streamed in the business world may not always + +407 +00:38:29,360 --> 00:38:33,940 +involve one type of cash flows Regular. The cash + +408 +00:38:33,940 --> 00:38:38,980 +flows may have a mixed pattern maybe after the + +409 +00:38:38,980 --> 00:38:41,740 +second year you get cash out of flow not cash + +410 +00:38:41,740 --> 00:38:47,450 +inflowسوف تأخذ صورة نجاتية على سبيل المثال مجموعات + +411 +00:38:47,450 --> 00:38:49,210 +تدفع المال مختلفة مع مجموعات تدفع المال مختلفة مع + +412 +00:38:49,210 --> 00:38:50,130 +مجموعات تدفع المال مختلفة مع مجموعة تدفع المال + +413 +00:38:50,130 --> 00:38:52,350 +مختلفة مع مجموعة تدفع المال مختلفة مع مجموعة تدفع + +414 +00:38:52,350 --> 00:38:55,010 +المال مختلفة مع مجموعة تدفع المال مختلفة مع مجموعة + +415 +00:38:55,010 --> 00:38:55,090 +تدفع المال مختلفة مع مجموعة تدفع المال مختلفة مع + +416 +00:38:55,090 --> 00:38:55,090 +مجموعة تدفع المال مختلفة مع مجموعة تدفع المال + +417 +00:38:55,090 --> 00:38:58,190 +مختلفة مع مجموعة تدفع المال مختلفة + +418 +00:38:58,190 --> 00:39:04,050 +مع مجموعة + +419 +00:39:04,050 --> 00:39:07,250 +تدفع المال م + +420 +00:39:14,110 --> 00:39:19,930 +ماذا نستطيع أن نفعل هو أننا نبدأ من هنا 500 دولار + +421 +00:39:19,930 --> 00:39:26,350 +تم تخلصه من كما قلنا هنا 1 اضافة I أعلى للقوة N 1 + +422 +00:39:26,350 --> 00:39:32,050 +ثم هذا أعلى للقوة 2 وهذا أعلى للقوة 3 انتهينا من + +423 +00:39:32,050 --> 00:39:42,260 +هذا الآن انت تخلص من هذابعد 1,2,3,4,5,6,7 سنة عامة + +424 +00:39:42,260 --> 00:39:47,660 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +425 +00:39:47,660 --> 00:39:48,240 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +426 +00:39:48,240 --> 00:39:48,260 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +427 +00:39:48,260 --> 00:39:48,360 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +428 +00:39:48,360 --> 00:39:48,380 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +429 +00:39:48,380 --> 00:39:49,640 +عامة عامة عامة عامة عامة عامة عامة عامة عامة عامة + +430 +00:39:49,640 --> 00:40:05,800 +عامة عامة عامة عامة عامة عامة عامة عام + +431 +00:40:06,660 --> 00:40:12,360 +look at this example what + +432 +00:40:12,360 --> 00:40:15,660 +is + +433 +00:40:15,660 --> 00:40:17,920 +the present value of cash flows of five hundred + +434 +00:40:17,920 --> 00:40:23,340 +dollars at the end of years through three at the + +435 +00:40:23,340 --> 00:40:25,420 +end of years through three so it means + +436 +00:40:30,790 --> 00:40:35,590 +الدفعات من نقل 800 في نهاية السنة الرابعة لذا نحن + +437 +00:40:35,590 --> 00:40:43,590 +لدينا واحد اثنان ثلاث نحن نحصل على 500 دولار حسنا + +438 +00:40:43,590 --> 00:40:48,730 +ثم في السنة الرابعة لدينا واحد اثنان ثلاث في السنة + +439 +00:40:48,730 --> 00:40:53,770 +الرابعة نحن نحصل على نقل 800 لذا نحن لدينا نقل 800 + +440 +00:40:53,770 --> 00:41:00,160 +ودفعات 800 في نهاية السنة الرابعة هي 5 من 10so + +441 +00:41:00,160 --> 00:41:08,200 +five six seven eight nine and ten five hundred + +442 +00:41:08,200 --> 00:41:17,320 +five hundred five hundred and five hundred sorry + +443 +00:41:17,320 --> 00:41:24,760 +او eight hundred okay eight eight + +444 +00:41:28,340 --> 00:41:37,420 +ماذا نستطيع أن نفعل بهذا؟ أولاً، + +445 +00:41:37,420 --> 00:41:44,280 +لدينا هذه الميزة المفروضة + +446 +00:41:44,280 --> 00:41:49,480 +على الميزة كل + +447 +00:41:49,480 --> 00:41:55,380 +هذه الميزة كميزة مفروضة وانت تضيف الميزة الموجودة + +448 +00:41:55,380 --> 00:42:00,720 +في الميزةمرة واحدة اقل واحدة واحدة اكتر واحدة اكتر + +449 +00:42:00,720 --> 00:42:02,520 +واحدة اكتر واحدة اكتر واحدة اكتر واحدة اكتر واحدة + +450 +00:42:02,520 --> 00:42:04,380 +اكتر واحدة اكتر واحدة اكتر واحدة اكتر واحدة اكتر + +451 +00:42:04,380 --> 00:42:04,420 +واحدة اكتر واحدة اكتر واحدة اكتر واحدة اكتر واحدة + +452 +00:42:04,420 --> 00:42:08,180 +اكتر واحدة اكتر واحدة اكتر واحدة اكتر واحدة اكتر + +453 +00:42:08,180 --> 00:42:10,740 +واحدة اكتر واحدة اكتر واحدة اكتر واحدة اكتر واحدة + +454 +00:42:10,740 --> 00:42:12,080 +اكتر واحدة اكتر واحدة اكتر واحدة اكتر واحدة اكتر + +455 +00:42:12,080 --> 00:42:25,020 +واحدة اكتر واحدة + +456 +00:42:28,170 --> 00:42:33,390 +هذا لديه تخصيص خاص لانه + +457 +00:42:33,390 --> 00:42:38,310 +يأتي بعد 4 سنة لديه تخصيص خاص لانه يأتي بعد 4 سنة + +458 +00:42:38,310 --> 00:42:41,930 +لديه تخصيص خاص لانه يأتي بعد 4 سنة لديه تخصيص خاص + +459 +00:42:41,930 --> 00:42:41,930 +لانه يأتي بعد 4 سنة لديه تخصيص خاص لانه يأتي بعد 4 + +460 +00:42:41,930 --> 00:42:41,930 +سنة لديه تخصيص خاص لانه يأتي بعد 4 سنة لديه تخصيص + +461 +00:42:41,930 --> 00:42:42,070 +خاص لانه يأتي بعد 4 سنة لديه تخصيص خاص لانه يأتي + +462 +00:42:42,070 --> 00:42:44,370 +بعد 4 سنة لديه تخصيص خاص لانه يأتي بعد 4 سنة لديه + +463 +00:42:44,370 --> 00:42:48,810 +تخصيص خاص لانه يأتي بعد 4 سنة لديه + +464 +00:42:48,810 --> 00:42:56,530 +تخصيص خاص لانone divided by one plus I raised to + +465 +00:42:56,530 --> 00:43:01,830 +the power one two three four five six seven sorry + +466 +00:43:01,830 --> 00:43:09,210 +one two three four five six yes okay six payments + +467 +00:43:09,210 --> 00:43:17,310 +divided by I and that's it then you get the + +468 +00:43:17,310 --> 00:43:20,910 +results when + +469 +00:43:20,910 --> 00:43:24,120 +you get the resultsهذا النتيجة التي قمت بإعطائها + +470 +00:43:24,120 --> 00:43:33,220 +تسكت في السنة الخامسة في السنة + +471 +00:43:33,220 --> 00:43:36,600 +الخامسة في السنة + +472 +00:43:36,600 --> 00:43:37,380 +الخامسة في السنة الخامسة في السنة الخامسة في السنة + +473 +00:43:37,380 --> 00:43:37,820 +الخامسة في السنة الخامسة في السنة الخامسة في السنة + +474 +00:43:37,820 --> 00:43:37,820 +الخامسة في السنة الخامسة في السنة الخامسة في السنة + +475 +00:43:37,820 --> 00:43:38,460 +الخامسة في السنة الخامسة في السنة الخامسة في السنة + +476 +00:43:38,460 --> 00:43:38,460 +الخامسة في السنة الخامسة في السنة الخامسة في السنة + +477 +00:43:38,460 --> 00:43:38,500 +الخامسة في السنة الخامسة في السنة الخامسة في السنة + +478 +00:43:38,500 --> 00:43:40,460 +الخامسة في السنة الخامسة في السنة الخامسة في السنة + +479 +00:43:40,460 --> 00:43:48,360 +الخامسة في السنة الخامسة في + +480 +00:43:48,360 --> 00:43:49,040 +السنة + +481 +00:43:53,440 --> 00:43:59,780 +مثل ما فعلناه هنا في الأول ثلاث سنة ثم هذه ثم تفعل + +482 +00:43:59,780 --> 00:44:06,300 +الواجبات في البداية من السنوات لمدة خمس سنة في + +483 +00:44:06,300 --> 00:44:12,880 +نهاية السنة الرابعة و تحاول ان تفعلها بنفسك و ترى + +484 +00:44:12,880 --> 00:44:13,280 +النتائج + +485 +00:44:21,760 --> 00:44:23,720 +هذا هو العملي المعامل المعامل المعامل المعامل + +486 +00:44:23,720 --> 00:44:25,040 +المعامل المعامل المعامل المعامل المعامل المعامل + +487 +00:44:25,040 --> 00:44:27,700 +المعامل المعامل المعامل المعامل المعامل المعامل + +488 +00:44:27,700 --> 00:44:34,480 +المعامل المعامل المعامل المعامل المعامل المعامل + +489 +00:44:34,480 --> 00:44:38,700 +المعامل المعامل المعامل المعامل المعامل المعامل + +490 +00:44:38,700 --> 00:44:39,840 +المعامل المعامل المعامل المعامل المعامل المعامل + +491 +00:44:39,840 --> 00:44:41,480 +المعامل المعامل المعامل المعامل المعامل المعامل + +492 +00:44:41,480 --> 00:44:42,000 +المعامل المعامل المعامل المعامل المعامل المعامل + +493 +00:44:42,000 --> 00:44:45,220 +المعامل المعامل المعامل المعامل المعامل المعامل + +494 +00:44:45,220 --> 00:44:51,750 +المعامل المعامل المعand this is the end of chapter + +495 +00:44:51,750 --> 00:44:56,210 +six on Saturday we will talk about chapter seven + +496 +00:44:56,210 --> 00:45:01,770 +so prepare yourself okay I may ask Noor to to do + +497 +00:45:01,770 --> 00:45:08,590 +some calculations and to answer and to answer the + +498 +00:45:08,590 --> 00:45:12,330 +questions okay يعطيكم العافية +