This O work O was O supported O by O grants O from O the B-ORG Laboratory I-ORG of I-ORG Parasite I-ORG and I-ORG Vector I-ORG Biology I-ORG MOH I-ORG China I-ORG No. O WSBKTKT201402 B-AWARD to O ZL O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 81371841 B-AWARD to O JC O and O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG China I-ORG No. O ZR2014YL031 B-AWARD to O HL O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O National B-ORG Science I-ORG Fund I-ORG of I-ORG China I-ORG grant O no. O 21390201 B-AWARD the O Major O projects O of O natural B-ORG science I-ORG research I-ORG in I-ORG Jiangsu I-ORG Province I-ORG grant O no. O 15KJA530002 B-AWARD fund O from O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Materials-Oriented I-ORG Chemical I-ORG Engineering I-ORG ZK201605 O KL15-07 O CAS B-ORG Key I-ORG Laboratory I-ORG of I-ORG Bio-based I-ORG Materials I-ORG no. O KLBM2016009 B-AWARD and O the O Priority O Academic O Program O from O Development O of O Jiangsu O Higher O Education O Institutions O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31700065 B-AWARD the B-ORG Shandong I-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O ZR2017BC040 B-AWARD and O the B-ORG Innovation I-ORG Project I-ORG of I-ORG the I-ORG Shandong I-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG No. O 201604 B-AWARD The O dHCP O project O was O funded O by O the O European O Research O Council O under O the O European B-ORG Union I-ORG Seventh I-ORG Framework I-ORG Programme I-ORG FR/2007-2013)/ERC O Grant I-ORG Agreement I-ORG no. O 319456 B-AWARD The O authors O acknowledge O infrastructure O support O from O the O National O Institute O for O Health O Research O Mental O Health O Biomedical O Research O Centre O at O South O London O Maudsley O NHS O Foundation O Trust O King’s O College O London O the O National O Institute O for O Health O Research O Mental O Health O Biomedical O Research O Centre O at O Guys O and O St O Thomas’ O Hospitals O NHS O Foundation O Trust O The O study O was O supported O in O part O by O the O Wellcome B-ORG Engineering I-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG Centre I-ORG for I-ORG Medical I-ORG Engineering I-ORG at O King’s O College O London O grant O WT B-AWARD 203148/Z/16/Z O and O the O Medical B-ORG Research I-ORG Council I-ORG UK) O grant O MR/K006355/1 B-AWARD Support O was O also O provided O by O EU-AIMS—a B-ORG European I-ORG Innovative I-ORG Medicines I-ORG Initiative I-ORG Flemish B-ORG Research I-ORG Foundation I-ORG grant O number O 12ZV420N B-AWARD to O D.C O Sir O Henry O Dale O Fellowship O jointly O funded O by O the O Wellcome B-ORG Trust I-ORG and O the O Royal B-ORG Society I-ORG grant O 206675/Z/17/Z B-AWARD to O J.O O G.M O received O support O from O the O Sackler B-ORG Institute I-ORG for I-ORG Translational I-ORG Neurodevelopment I-ORG at O King’s O College O London O and O from O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG NIHR I-ORG Maudsley I-ORG Biomedical I-ORG Research I-ORG Centre I-ORG BRC O The O views O expressed O are O those O of O the O authors O and O not O necessarily O those O of O the O NHS O the O NIHR O the O Department O of O Health O Medical O Research O Council O Centre O for O Neurodevelopmental O Disorders O King’s O College O London O grant O MR/N026063/1 O to O J.O O A.D.E O and O G.M O This O work O was O supported O by O the O JPND B-ORG I-ORG DEMTEST I-ORG 01ED1201A O PRIORITY B-ORG FP7-KBBE-2007-2A O Robert B-ORG Koch I-ORG Institute I-ORG through I-ORG funds I-ORG 1369-341 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81370751 O Guangdong B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2014A030313502 O Guangzhou B-ORG City I-ORG Science I-ORG and I-ORG Technology I-ORG Administration I-ORG 201510010014 O Guangdong B-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG Foundation I-ORG 2013B021800273 O and O Guangdong B-ORG Education I-ORG Department I-ORG Foundation I-ORG 2014KTSCX101 O EPSRC B-ORG Grant O EP/H0313671 O to O D.B O in O part O EP/G0395851 B-AWARD to O D.B O D.O O Leverhulme B-ORG Trust I-ORG Grant O RP2013-K-017 O to O D.B O A.S O Swiss B-ORG National I-ORG Science I-ORG Foundation I-ORG Grant O 31003A O 166684 I-AWARD to O A.S O AWM O Mentor O Travel O Grant O National B-ORG Science I-ORG Foundation I-ORG Grants O DMS-1406481 B-AWARD DMS-1600365 B-AWARD to O D.O O The O open O access O publication O charge O for O this O paper O has O been O waived O by O Oxford O University O Press O –NAREditorial O Board O members O are O entitled O to O one O freepaper O per O year O in O recognition O of O their O work O on O behalf O of O the O journal O This O research O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No: O 5177060654 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No: O 2017M611560 B-AWARD Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2009DFB60160 O Yunnan O Hu O Zhiyu O Expert O Workstation O [2014 O 5). O We O also O would O like O to O thank O the O Center B-ORG for I-ORG Advanced I-ORG Electronic I-ORG Materials I-ORG and I-ORG Devices I-ORG AEMD I-ORG of O Shanghai B-ORG Jiao I-ORG Tong I-ORG University I-ORG and O Instrumental B-ORG Analysis I-ORG Center I-ORG and O the O startup O fund O of O Shanghai B-ORG Jiao I-ORG Tong I-ORG University I-ORG This O work O was O supported O by O the B-ORG Key I-ORG Laboratory I-ORG of I-ORG Marine I-ORG Ecology I-ORG and I-ORG Environmental I-ORG Science I-ORG and I-ORG Engineering I-ORG SOA I-ORG No. O MESE-2017-07 B-AWARD the B-ORG Open I-ORG Foundation I-ORG of I-ORG Fishery I-ORG Sciences I-ORG in I-ORG the I-ORG First-Class I-ORG Subjects I-ORG of I-ORG Zhejiang I-ORG grant O number O 20160009 B-AWARD and O the B-ORG Fund I-ORG of I-ORG Key I-ORG Laboratory I-ORG of I-ORG South I-ORG China I-ORG Sea I-ORG Fishery I-ORG Resources I-ORG Exploitation I-ORG I-ORG Utilization I-ORG Ministry I-ORG of I-ORG Agriculture I-ORG P. I-ORG R. I-ORG China I-ORG grant O number O FREU2016-03 B-AWARD This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O 2018YFD0500204 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grants O 31970074 O and O 31770087 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG grants O 2662017PY112 B-AWARD This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31602095 B-AWARD the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-37 O and O the B-ORG Central I-ORG Public I-ORG Interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG Y2016CG23 O The O funder O played O no O role O in O the O design O as O well O as O conclusion O of O the O study O D.B O was O supported O by O the O Healthy O Brains O Healthy O Lives O initiative O Canada B-ORG First I-ORG Research I-ORG Excellence I-ORG Fund I-ORG and O by O the O CIFAR B-ORG Artificial I-ORG Intelligence I-ORG Chairs I-ORG program I-ORG Canada B-ORG Institute I-ORG for I-ORG Advanced I-ORG Research I-ORG D.B O was O also O funded O by O the O Deutsche B-ORG Forschungsgemeinschaft I-ORG DFG O BZ2/2–1 B-AWARD BZ2/3–1 B-AWARD and O BZ2/4–1 B-AWARD International B-ORG Research I-ORG Training I-ORG Group I-ORG IRTG2150 B-AWARD Amazon O AWS O Research O Grant O 2016 O and O 2017 O as O well O as O the O START B-ORG Program I-ORG of I-ORG the I-ORG Faculty I-ORG of I-ORG Medicine I-ORG 126/16 O and O Exploratory B-ORG Research I-ORG Space I-ORG OPSF449 O RWTH O Aachen O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81572262 O Jiangsu B-ORG Province’s I-ORG Key I-ORG Provincial I-ORG Talents I-ORG Program I-ORG ZDRCA2016028 O 333 B-ORG High I-ORG Class I-ORG Talented I-ORG Man I-ORG Project I-ORG BRA2016516 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institution I-ORG of I-ORG China I-ORG 18KJB320006 O and O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG 2017YFC1309201 O This O research O was O funded O by O the O Science O Challenge O Project O No.TZ2016001 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 11602251 B-AWARD 51372188 I-AWARD 51861145306 I-AWARD and I-AWARD 51872212 O and O by O the O 111 B-ORG Project I-ORG B13035 B-AWARD This O research O was O also O supported O by O the O International B-ORG Science I-ORG Technology I-ORG Cooperation I-ORG Program I-ORG of I-ORG China I-ORG 2014DFA53090 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG China I-ORG 2016CFA006 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG WUT O 2017YB004 B-AWARD 2018III016 B-AWARD and O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Advanced I-ORG Technology I-ORG for I-ORG Materials I-ORG Synthesis I-ORG and I-ORG Processing I-ORG WUT O Grant I-AWARD No. I-AWARD 2019-KF-12 O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 81473180 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province O grant O number O H2017206158 B-AWARD and O the O Key B-ORG Project I-ORG of I-ORG Hebei I-ORG Medical I-ORG Science O grant O number O 20170472 B-AWARD P.C O was O supported O by O The B-ORG University I-ORG of I-ORG Adelaide I-ORG through O an O International B-AWARD Post-Graduate I-AWARD Research I-AWARD Scholarship O and O through O the O Royal B-ORG Society I-ORG of I-ORG South I-ORG Australia I-ORG D.W O was O supported O by O The O University B-ORG of I-ORG Canberra I-ORG M.S O received O funding O from O The O Australian B-ORG Antarctic I-ORG Division I-ORG science O project O 2355 B-AWARD A.C O and O M.S O received O funding O for O this O project O through O Australian B-ORG Research I-ORG Council I-ORG linkage O grant O LP0991985 B-AWARD which O also O supported O L.C O in O this O project O M.S O and O P.C O received O funding O for O this O project O from O the O Sir B-ORG Mark I-ORG Mitchell I-ORG Foundation I-ORG This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31561143006 B-AWARD Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG China I-ORG No. O ZR2014YL014 B-AWARD and O the O Taishan B-ORG Scholars I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG China I-ORG No. O 2016-2020 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O grants O from O CNPq B-ORG 455294/2014-3 B-AWARD and O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG Grant O numbers O HL074237 B-AWARD HL101434 B-AWARD and O HL072751 B-AWARD Work O in O MPM’s O lab O is O supported O by O the O Medical B-ORG Research I-ORG Council I-ORG UK I-ORG MC_U105663142 B-AWARD and O by O a O Wellcome B-ORG Trust I-ORG Investigator O award O to O MPM O 110159/Z/15/Z B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81502616 B-AWARD the O National B-ORG Social I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.16BGL183 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG No. O 2017JM8013 B-AWARD and O No. O 2015JM8415 B-AWARD This O study O was O financially O supported O by O the O key B-ORG social I-ORG development I-ORG projects I-ORG of I-ORG key I-ORG R I-ORG I-ORG D I-ORG plans I-ORG in I-ORG Jiangsu I-ORG Province I-ORG BE2019708 O key B-ORG technical I-ORG research I-ORG projects I-ORG of I-ORG environmental I-ORG protection I-ORG in I-ORG Jiangsu I-ORG Province I-ORG 2018008 O and O program B-ORG B I-ORG for I-ORG Outstanding I-ORG PhD I-ORG candidate I-ORG of I-ORG Nanjing I-ORG University I-ORG No.201901B032 O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 11904193 O and O 51973100 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG China I-ORG No. O ZR2019BF031 B-AWARD State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Bio-Fibers I-ORG and I-ORG Eco-Textiles I-ORG Qingdao I-ORG university I-ORG RZ2000003334 O and O ZDKT202108 B-AWARD and O the O National B-ORG Key I-ORG Research I-ORG Development I-ORG Project I-ORG 2019YFC0121402 O This O work O was O financially O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFD0500103 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31772747 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Research I-ORG Program I-ORG during I-ORG the I-ORG 13th I-ORG Five-Year I-ORG Plan I-ORG Period I-ORG of I-ORG the I-ORG Jilin I-ORG Educational I-ORG Committee I-ORG No. O JJKH20190172KJ B-AWARD and O the O Program B-ORG for I-ORG JLU I-ORG Science I-ORG and I-ORG Technology I-ORG Innovative I-ORG Research I-ORG Team I-ORG JLUSTIRT B-ORG No. O 2017TD-28 B-AWARD This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG grant O no. O 2013BAD01B07 B-AWARD 2012BAD01B07 O the B-ORG National I-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O no. O 2013AA102706 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG no. O 2015ZCQ-YL-03 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O Basic O Science O Research O Program O through O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O Nos O 2021R1I1A1A01049542 B-AWARD and O NRF-2022R1A2B5B03002312 B-AWARD the O Korea B-ORG Institute I-ORG of I-ORG Marine I-ORG Science I-ORG and I-ORG Technology I-ORG Promotion I-ORG KIMST O funded O by O the O Ministry B-ORG of I-ORG Oceans I-ORG and I-ORG Fisheries I-ORG MOF O 20210469 O and O the O European B-ORG Marine I-ORG Biological I-ORG Resource I-ORG Centre I-ORG EMBRC)-France I-ORG whose O French O state O funds O are O managed O by O the O ANR O within O the O “Investing O for O the O future O program” O under O reference O ANR-10-INBS-02 B-AWARD This O study O was O part O of O VAA O fellowship O from O the O Andalucía B-ORG Talent-Hub I-ORG Program I-ORG launched I-ORG by I-ORG the I-ORG Andalusian I-ORG Knowledge I-ORG Agency I-ORG co-funded I-ORG by I-ORG the I-ORG European I-ORG Union’s I-ORG Seventh I-ORG Framework I-ORG Program I-ORG Marie I-ORG Skłodowska-Curie I-ORG actions I-ORG COFUND–Grant O Agreement I-AWARD nº291780 O and O the O Junta B-ORG de I-ORG Andalucía I-ORG ICR O grant O number O FPU13/01993 B-AWARD was O supported O by O the O Spanish B-ORG Ministry I-ORG of I-ORG Education O This O study O was O also O partially O funded O by O the O Regional B-ORG Ministry I-ORG of I-ORG Health I-ORG of I-ORG the I-ORG Junta I-ORG de I-ORG Andalucía I-ORG PI-0395-2016 O and O the O University B-ORG of I-ORG Granada I-ORG Plan I-ORG Propio I-ORG de I-ORG Investigación I-ORG 2016 I-ORG Excellence I-ORG actions I-ORG Units I-ORG of I-ORG Excellence I-ORG Unit I-ORG of I-ORG Excellence I-ORG on I-ORG Exercise I-ORG and I-ORG Health I-ORG UCEES O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O is O supported O by O the O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG CIHR O HOP B-AWARD 81389 I-AWARD to O L.K O Nankai B-ORG University I-ORG starting O fund O ZB15006101 O to O M. O W O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81571991 O to O M. O W O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the B-ORG Central I-ORG Level I-ORG Scientific I-ORG Research I-ORG Institutes I-ORG for I-ORG Basic I-ORG R I-ORG I-ORG D I-ORG Special I-ORG Fund I-ORG Business I-ORG Grant O No.1610322015014 O the B-ORG Earmarked I-ORG Fund I-ORG for I-ORG Modern I-ORG China I-ORG Wool I-ORG I-ORG Cashmere I-ORG Technology I-ORG Research I-ORG System I-ORG Grant O No.nycytx-40-3 O and O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG for I-ORG Young I-ORG Scholars I-ORG of I-ORG China I-ORG Grant O No.31402057 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81771338 B-AWARD the B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG grant O number O 2016YFC1101501 B-AWARD the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG grant O number O XDA16020103 O and O the B-ORG Youth I-ORG Innovation I-ORG Promotion I-ORG Association I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG 2016291 B-AWARD Grant O to O X.L O This O work O was O supported O by O The O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No.81300779 O Zhenzhen O Zhang O The O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province I-ORG of O China O Grant O No.20180550524 O Xiuhong O Qin O The O Foundation B-ORG of I-ORG Liaoning I-ORG Educational I-ORG Committee I-ORG Grant O No. O LQ2017016 B-AWARD Xiuhong O Qin O in O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O funded O by O Haitao B-ORG Ding I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Joint I-ORG Fund I-ORG Project O grant O number O U1864206 B-AWARD Haitao B-ORG Ding I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation O grant O number O 51905045 B-AWARD Niaona B-ORG Zhang I-ORG of I-ORG the I-ORG Jilin I-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Plan I-ORG Project O grant O number O 20220203166SF B-AWARD and O Niaona B-ORG Zhang I-ORG of I-ORG the I-ORG Open I-ORG Fund I-ORG of O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Automotive I-ORG Simulation I-ORG and I-ORG Control I-ORG of I-ORG Jilin I-ORG University I-ORG grant O number O 20210237 B-AWARD This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32102134 O Key B-ORG R&D I-ORG plan I-ORG of I-ORG Shandong I-ORG Province I-ORG 2022CXGC010603 O Jiangsu B-ORG Agriculture I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Fund I-ORG CX(22)3073 O and O Yangzhou B-ORG University I-ORG High-level I-ORG Talent I-ORG Research I-ORG Fund I-ORG Project I-ORG 137012132 O Jiangsu B-ORG University I-ORG Student I-ORG Training I-ORG Program I-ORG 202211117088Y O and O sponsored O by O a O project O Funded O by O the O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0907100 O the O Guangdong B-ORG Provincial I-ORG Medical I-ORG Science I-ORG Research I-ORG Fundation O Guangdong O China O A2018141 O the B-ORG Guangdong I-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation O Guangdong O China O 2015A030313891 O The O Guangzhou O Biobank O Cohort O Study O GBCS O Cardiovascular O Disease O Sub-study O was O funded O by O an O NSFC/RGC O No. O 30518001 O HKU720/05 O grant O The O GBCS O was O funded O by O the O University O of O Hong O Kong O Foundation O for O Educational O Development O and O Research O Hong O Kong O the O Guangzhou O Public O Health O Bureau O and O the O Guangzhou O Science O and O Technology O Bureau O Guangzhou O China O and O The O University O of O Birmingham O UK. O This O research O was O funded O by O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq O grant O number O 141341/2020-3 B-AWARD Paraiba B-ORG State I-ORG Research I-ORG Foundation I-ORG FAPESQ O grant O number O 2002/2022 B-AWARD Coordination B-ORG of I-ORG Improvement I-ORG of I-ORG Higher I-ORG Education I-ORG Personnel—Brazil I-ORG CAPES)—grant O number O 88887.513720/2020-00 B-AWARD and O Universidad B-ORG Militar I-ORG Nueva I-ORG Granada I-ORG UMNG O grant O number O IMP-CIAS-2924 B-AWARD 2020 O Supported O by O Scientific B-ORG and I-ORG technological I-ORG innovation I-ORG joint I-ORG capital I-ORG projects I-ORG of I-ORG Fujian I-ORG Province I-ORG China I-ORG No. O 2016Y9031 B-AWARD Minimally B-ORG invasive I-ORG medical I-ORG center I-ORG of I-ORG Fujian I-ORG Province I-ORG No. O 2017]171 B-AWARD Startup B-ORG Fund I-ORG for I-ORG scientific I-ORG research I-ORG Fujian I-ORG Medical I-ORG University I-ORG No. O 2016QH024 B-AWARD Fujian B-ORG province I-ORG medical I-ORG innovation I-ORG project I-ORG 2015-CXB-16 O The O funding O bodies O were O neither O involved O in O the O design O of O the O study O nor O in O the O collection O analysis O or O interpretation O of O data O nor O in O the O writing O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Research I-ORG Foundation I-ORG NRF-2017R1D1A3B03030972 O the B-AWARD National I-AWARD Scientist I-AWARD Honor I-AWARD Program O the B-ORG Korea I-ORG Health I-ORG Technology I-ORG R&D I-ORG Project I-ORG HI18C0158 O and O the B-AWARD Bio I-AWARD I-AWARD Medical I-AWARD Technology I-AWARD Development I-AWARD Program I-AWARD of I-AWARD the I-AWARD National I-AWARD Research I-AWARD Foundation I-AWARD NRF I-AWARD funded O by O the B-ORG Ministry I-ORG of I-ORG Science I-ORG O ICT B-ORG 2017M3A9G7073521 O to O J.-A O L. O and O by O the O Basic O Science O Research O Program O through O the O NRF O NRF-2018R1D1A1B07048822 O to O D.-J.J O TTJC O was O funded O by O the O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG of O Australia O 1053226 O MA O was O funded O by O a O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG AFL O Fellowship O BB/M013596/1 O MH O was O funded O by O a O grant O from O the O Wellcome B-ORG Trust I-ORG 098282 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O SMH O is O aMedical O Research I-ORG Council(MRC O Scientist O with O MRC O Programme O Grant O G1001029 B-AWARD and O MR/N021231/1 B-AWARD andBiotechnology O and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council(BBSRC O BB/K010115/1 B-AWARD support O CLH O had O a O MRC O PhD O studentship O RDK O was O funded O by O BBSRC O BB/I025883/1 O andWellcome O Trust(101529/Z/13/Z O The O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31670407 O the O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG for I-ORG Social I-ORG Livelihood I-ORG of I-ORG Chongqing I-ORG cstc2016shmszx80107 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG XDJK2018B021 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81472987 B-AWARD and O 81773441 B-AWARD Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O No. O 7162094 B-AWARD and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG P.R I-ORG China I-ORG Grant O No. O 2016YFC1000501 B-AWARD This O work O was O financially O supported O by O the O Hubei B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O no. I-AWARD 2019CFB265 O the O Research B-ORG and I-ORG Innovation I-ORG Initiatives I-ORG of I-ORG WHPU I-ORG Grant O no. I-AWARD 2019Y03 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O no. I-AWARD 31700100 O The O Funding O bodies O were O not O involved O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O made O possible O by O a O grant O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81700451 O to O Z.Z O Q.J O was O supported O by O the O Chinese B-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG Initiative I-ORG for I-ORG Innovative I-ORG Medicine I-ORG CAMS-I2M O the O National O Natural O Science O Foundation O of O China O 81771620 O Q.L O was O supported O by O the O Beijing B-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospitals I-ORG Incubating I-ORG Program I-ORG PX2020054 O This O research O was O funded O by O the O Korea B-ORG Drug I-ORG Development I-ORG Fund I-ORG KDDF-20160803 O Ministry B-ORG of I-ORG Science I-ORG ICT I-ORG and I-ORG Future I-ORG Planning I-ORG 2016-935470 O and O Small B-ORG and I-ORG Medium I-ORG Business I-ORG Administration I-ORG C0406256 O This O study O was O funded O by O the O European B-ORG Research I-ORG Council I-ORG ERC O and O InflammaTENSION O ERC-CoG-726318 B-AWARD to O T.J.G O and O by O National B-ORG Science I-ORG Centre I-ORG of I-ORG Poland I-ORG grant O 2997/B/P01/2009/36 O and O British B-ORG Heart I-ORG Foundation I-ORG RE/13/5/30177 O This O work O was O partially O supported O by O the O grants O of O NIH/NCI B-ORG CA165980 O CA177665 B-AWARD and O CA112557 B-AWARD and O NIH/NIEHS B-ORG ES000260 B-AWARD as O well O as O Key B-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Team I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2013TD10 O The B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grants O 81570884 B-AWARD 81770961 O the B-ORG SMC-ChenXing I-ORG Yong I-ORG Scholar I-ORG Program I-ORG 2016 O Class I-AWARD A) O and O the B-ORG Shanghai I-ORG Municipal I-ORG Education I-ORG Commission-Gaofeng I-ORG Clinical I-ORG Medicine I-ORG Grant I-ORG 20152223 O Innovation B-ORG Fund I-ORG for I-ORG Translational I-ORG Medicine I-ORG 15ZH1005 O Ph.D B-ORG Programs I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG JiaoTong I-ORG University I-ORG School I-ORG of I-ORG Medicine I-ORG BXJ201834 O Innovative B-ORG research I-ORG team I-ORG of I-ORG high-level I-ORG local I-ORG universities I-ORG in I-ORG Shanghai I-ORG Department O of I-AWARD Ophthalmology I-AWARD Shanghai I-AWARD Ninth I-AWARD People I-AWARD Hospital O The O Interdisciplinary O Program O of O Shanghai O Jiao O Tong O University O YG2016MS02 O The O funders O had O no O role O in O the O design O of O the O study O nor O in O the O collection O analysis O and O interpretation O of O data O or O in O writing O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 51777149 B-AWARD and O 11927801 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of O China O grant O number O XJJ2018027 B-AWARD and O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China O grant O number O 2017YFF0209703 B-AWARD LZ O received O the O fundings O for O this O research O from O the B-ORG National I-ORG Key I-ORG Research I-ORG I-ORG Development I-ORG Program O grant O number O 2018YFD1000601 B-AWARD and O Key B-ORG Agricultural I-ORG Project I-ORG of I-ORG Department I-ORG of I-ORG Science I-ORG I-ORG Technology I-ORG of I-ORG Guizhou O grant O number O 2019]2377 B-AWARD and O Research B-ORG and I-ORG Innovation I-ORG Team I-ORG Foundation I-ORG of I-ORG Guizhou I-ORG Province I-ORG Education I-ORG Department O grant O numner O 2014]45 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O N.N.M.Z O is O supported O by O Ministry B-ORG of I-ORG Higher I-ORG Education I-ORG Fundamental O Research O Grant O Scheme O FRGS/1/2020/SKK0/UKM/03/3 B-AWARD S.E.S O is O supported O by O Akademi B-ORG Sains I-ORG Malaysia-Majlis I-ORG Kanser I-ORG Negara I-ORG MAKNA O Cancer O Research O Award O JJ-2020-001 B-AWARD and O Higher B-ORG Institute I-ORG Centre I-ORG of I-ORG Excellence I-ORG Grant O HICoE O AKU49 B-AWARD This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51603029 B-AWARD and O 51773028 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017M623001 O and O National B-ORG Postdoctoral I-ORG Program I-ORG for I-ORG Innovative I-ORG Talents I-ORG BX201700044 O The O present O study O is O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81771602 B-AWARD to O Bin O Liu O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2017A030313826 B-AWARD to O Bin O Liu O Sun B-ORG Yat-Sen I-ORG University I-ORG Clinical I-ORG Research I-ORG 5010 I-ORG Program I-ORG No.2016014 O to O Bin O Liu O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 16ykpy19 B-AWARD to O Bin O Liu O and O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2017A020214014 B-AWARD to O Zilian O Wang O The O funding O bodies O had O no O role O in O the O design O of O study O collection O analysis O and O interpretation O of O data O or O in O writing O of O the O manuscript O This O work O has O been O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC1600802 O XL O is O supported O by O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Cotton I-ORG Biology I-ORG Open I-ORG Fund I-ORG CB2018A22 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Henan I-ORG Province I-ORG of O China O 182300410083 O XYP O is O supported O by O the O Natural B-ORG Science I-ORG Program I-ORG of I-ORG the I-ORG Educational I-ORG Commission I-ORG of I-ORG Henan I-ORG Province I-ORG of I-ORG China I-ORG 18A310013 O Publication O costs O for O this O work O were O funded O the O Science B-ORG and I-ORG Technique I-ORG Foundation I-ORG of I-ORG Henan I-ORG Province I-ORG 182102310644 O This O work O was O supported O by O the O National B-ORG Basic I-ORG Research I-ORG Programs I-ORG of I-ORG China I-ORG No. O 2017YFA0105001 B-AWARD and I-AWARD 2016YFC1000606 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Project O No. O 31671544 B-AWARD and I-AWARD 31371506 O and O the O Key B-ORG Research I-ORG I-ORG Development I-ORG Program I-ORG of I-ORG Guangzhou I-ORG Regenerative I-ORG Medicine I-ORG and I-ORG Health I-ORG Guangdong I-ORG Laboratory I-ORG No. O 018GZR110104002 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O authors O are O grateful O for O financial O support O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 11674199 O 11774208 I-AWARD 11804200 I-AWARD 61205174 O Shandong B-ORG Province I-ORG Natural I-ORG Science I-ORG Foundation I-ORG ZR2017BA004 O 2017GGX20120 I-AWARD ZR2016FP01 I-AWARD ZR2017BA018 O Shandong B-ORG Province I-ORG Youth I-ORG Foundation I-ORG ZR2018QF006 O and O the O China B-ORG Postdoctoral I-ORG science I-ORG Foundation I-ORG 2016M602177 O This O work O was O supported O by O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Hunan I-ORG Province I-ORG 2022SK2079 O 2018SK2090 B-AWARD 2019SK2221 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan-Youth I-ORG Foundation I-ORG Project I-ORG 2020JJ5701 O 2019JJ50696 B-AWARD Program B-ORG of I-ORG Hunan I-ORG Human I-ORG Biobank I-ORG 2020TP3003 O European B-ORG Union I-ORG 765492 O to O M.H O Spanish B-ORG Government I-ORG AGL2017-88702-C2-2-R O to O M.H O J.L.O O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III O FEDER O funds O PIE16/00045 O to O J.A.M O Chair O ‘Doctors O Galera-Requena O in O cancer O stem O cell O research’ O to O JMA O and O by O the O Ministry B-ORG of I-ORG Education I-ORG of I-ORG Spain I-ORG FPU13/05662 O to O R.L O IFI16/00041 B-AWARD to O E.A O Strategic O Research O Area O SFO O program O of O the O Swedish O Research O Council O to O V.R O through O Stockholm O University O to O B.F O Funding O for O open O access O charge O Spanish O Government O AGL2017-88702-C2-2-R O This O research O was O funded O by O “BK O 21 O Plus O Project O Seoul O National I-ORG University I-ORG Interdisciplinary O Program O in O Landscape O Architecture O a O global O leadership O program O toward O innovative O green O infrastructure O the O Korea B-ORG Environmental I-ORG Industry I-ORG and I-ORG Technology I-ORG Institute I-ORG KEITI O grant O number O 2014-001-310007” O “the O Ministry O of O Education O of O the O Republic O of O Korea O and O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG under O grant O number O NRF-2017S1A5A8020226” O “Creative-Pioneering O Researchers I-AWARD Program I-AWARD through O Seoul O National O University O grant O number O 500-20170162” O “the O Ministry O of O Education O of O the O Republic O of O Korea O and O the O National O Research O Foundation O of O Korea O grant O number O NRF-2017S1A3A2066771” O and O “Korea O Environmental O Industry O and O Technology O Institute O KEITI O through O the O Climate O Change O Response O Technology O Project O funded O by O the O Korea O Ministry O of O Environment O MOE O grant O number O 201800131002” B-AWARD L.B O acknowledges O the O support O from O Else B-ORG Kröner I-ORG Fresenius I-ORG Center I-ORG and I-ORG DFG I-ORG project O number O ID O 413655771 B-AWARD Furthermore O L.B O thanks O the O European B-ORG Research I-ORG Council I-ORG ERC O for O a O Consolidator O Grant O ImmunoChip O 101045415 B-AWARD and O Helmholtz B-ORG Initiative I-ORG and I-ORG Networking I-ORG Fund I-ORG Monash-Helmholtz O Laboratory O for O Radio-Immuno-Theranostics O MHELTHERA O project O ID: O InterLabs-0031 B-AWARD This O work O was O supported O by O the O Chinese B-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG 31501250 O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0300306 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017M611255 O and O the O Shenyang B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 17-231-1-37 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O Financial B-ORG support I-ORG was I-ORG provided I-ORG by I-ORG the I-ORG China I-ORG Ocean I-ORG Mineral I-ORG Resources I-ORG R&D I-ORG Association I-ORG COMRA O program O No. O DY135-B2-01 I-AWARD to O Z.S O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 42176134 I-AWARD to O L.J O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2021TQ0397 I-AWARD to O S.W O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2018YFC0310701 I-AWARD to O Z.S O the O Scientific B-ORG Research I-ORG Foundation I-ORG of I-ORG Third I-ORG Institute I-ORG of I-ORG Oceanography I-ORG MNR I-ORG No. O 2019021 I-AWARD to O Z.S O the O IRP B-ORG 1211 I-ORG MicrobSea I-ORG No. O IRP1211 I-AWARD to O K.A O and O Z.S O the O National O Natural O Science O Foundation O of O China O No. O 91951201 I-AWARD to O X.Z O and O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2021YFF0501304 I-AWARD to O X.Z O This O research O was O funded O by O the O 973 B-ORG program I-ORG 2013CB955700 B-AWARD the O NSFC B-ORG projects I-ORG 41422603 B-AWARD and I-AWARD 91428308 O the O SOA B-ORG projects I-ORG GASI-03-01-02-03 B-AWARD and I-AWARD GASI-03-01-02-05 O The O cruise O was O supported O by O 973 B-ORG CHOICE-C I-ORG II I-ORG 2015CB954000 B-AWARD This O work O was O funded O by O FONDECYT B-ORG grant I-ORG 1130483 B-AWARD to O CC O Figueroa O and O Iniciativa B-ORG Científica I-ORG Milenio I-ORG ICM I-ORG NC120027 B-AWARD GI O Ballesteros O was O funded O by O CONICYT B-ORG PhD I-ORG fellowship I-ORG 21120371 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O in O part O by O grants O from O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universitiesn I-ORG of I-ORG China I-ORG Program O No. O 2662015PY018 B-AWARD the O 111 B-ORG Project I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG B08032 O the O National B-ORG 973 I-ORG Pre-project I-ORG 2010CB134401 O and O the O National B-ORG Transgenic I-ORG Project I-ORG 2009ZX08009-119B O SP O was O supported O by O a O R@MAP B-ORG Professor I-ORG grant I-ORG at I-ORG University I-ORG of I-ORG Melbourne I-ORG and I-ORG a I-ORG ChangJiang I-ORG scholarship I-ORG 52204-14004 O This O study O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundations I-ORG of I-ORG China I-ORG No. O 81971986 O and O the B-ORG General I-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG the I-ORG Education I-ORG Department I-ORG of I-ORG Zhejiang I-ORG Province I-ORG of I-ORG China I-ORG No. O Y201942210 O and O the B-ORG Planned I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Wenzhou I-ORG no. O Y20170204 O This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 31672643 B-AWARD 31372533 B-AWARD 31502152 B-AWARD the O General O Program O of O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG of O China O No. O BK20191145 B-AWARD Three O New O Projects O of O Agricultural B-ORG Aquaculture I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O Y2018-17 B-AWARD and O the O Special B-ORG Fund I-ORG of I-ORG Jiangsu I-ORG Province I-ORG for I-ORG the I-ORG Transformation I-ORG of I-ORG Scientific I-ORG and I-ORG Technological I-ORG Achievements I-ORG No. O BA2015167 B-AWARD This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2019YFA0210202 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.61771096 O and O No. O 61671116 B-AWARD and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No.ZYGX2019J012 O and O No.ZYGX2019Z006 O The O authors O gratefully O acknowledge O assistance O from O the B-ORG National I-ORG Key I-ORG Research I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0201404 O and O 2018YFD0200100 B-AWARD the B-ORG National I-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32060622 O the B-ORG Outstanding I-ORG Young I-ORG Scientific I-ORG and I-ORG Technological I-ORG Talents I-ORG Project I-ORG of I-ORG Guizhou I-ORG Province I-ORG [2019]5646 O and O the B-ORG Construction I-ORG Project I-ORG of I-ORG Key I-ORG Laboratories I-ORG from I-ORG the I-ORG Education I-ORG Department I-ORG of I-ORG Guizhou I-ORG Province I-ORG QJHKY O 2018 I-AWARD 001 O This O work O was O supported O by O Project B-ORG of I-ORG Education I-ORG Department I-ORG in I-ORG Sichuan O China O 18ZB0633 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Southwest I-ORG Medical I-ORG University I-ORG No. O 2017-ZRZD-022 B-AWARD and O 2018-ZRZD-011 B-AWARD and O National B-ORG Undergraduate I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Project I-ORG No.201816032021 O The O funders O had O no O role O in O study O design O data O collection O and O interpretation O or O the O decision O to O submit O the O work O for O publication O This O research O was O funded O by O the O STI B-ORG 2030—Major I-ORG Projects I-ORG No. O 2021ZD0201301 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 12101133 B-AWARD and O Shanghai B-ORG Sailing I-ORG Program I-ORG No. O 21YF1402300 B-AWARD This O work O was O also O supported O by O Shanghai B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG No. O 2021SHZDZX0103 B-AWARD This O research O was O funded O by O the O Guizhou O Provincial I-ORG Department I-ORG of I-ORG Education I-ORG Young I-ORG Science I-ORG and I-ORG Technology I-ORG Talent I-ORG Growth I-ORG Project O grant O No. O Qian B-AWARD Jiao I-AWARD Ji I-AWARD 2022 I-AWARD 119 O Guizhou B-ORG University I-ORG Natural I-ORG Science I-ORG Special I-ORG Special I-ORG Post I-ORG Scientific I-ORG Research I-ORG Fund I-ORG Project I-ORG grant O No. O Guida B-AWARD Tegang I-AWARD Hezi I-AWARD 2022 I-AWARD 17 O Strategic B-ORG Pilot I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG grant O No. O XDA28080304 B-AWARD The B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O No. O 2021YFD1600401 B-AWARD and O The B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Guizhou I-ORG Province I-ORG grant O No. O Qian B-AWARD Ke I-AWARD He I-AWARD Zhi I-AWARD Cheng I-AWARD 2021 I-AWARD Generally I-AWARD 200 O Economic B-ORG and I-ORG Social I-ORG Research I-ORG Council I-ORG Studentship O ES/J500215/1 O Prins B-ORG Bernhard I-ORG Cultuurfonds I-ORG grant O E/30/30.13.0630/HVH/IE O and O University B-ORG of I-ORG York I-ORG Research I-ORG Priming I-ORG Fund I-ORG H0022034 O to O Rob O Jenkins O This O work O was O supported O by O grants O from O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81773734 B-AWARD to O XH O Li O Hunan B-ORG Young I-ORG Talent I-ORG grant I-ORG 2017RS3060 O to O XH O Li O and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG Central I-ORG South I-ORG University I-ORG Grant O No. O 2018zzts863 B-AWARD to O YY O Cao O This O study O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFA0104800 O 2016YFC1101400 O Nature B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31470947 O 31771062 O and O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2017SZ0031 O We O thank O all O of O these O funds O for O the O collection O analysis O and O explanation O of O the O article O data O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 11604154 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O BK20181315 B-AWARD the O Agricultural B-ORG Machinery I-ORG Three I-ORG New I-ORG Project I-ORG No. O SZ120170036 B-AWARD the O Asia O hub O on O WEF O and O Agriculture O the O NAU-MSU O Joint O Project O No. O 2017-H-11 B-AWARD and O the O Key O Research O Plan O of O Yangzhou O No. O YZ2018038 B-AWARD This O work O was O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Henan I-ORG Province I-ORG No. O 162300410040 O Outstanding B-ORG Youth I-ORG Science I-ORG Foundation I-ORG of I-ORG Henan I-ORG University I-ORG No. O yqpy20140036 O Science B-ORG and I-ORG Technology I-ORG Development I-ORG Program I-ORG of I-ORG Henan I-ORG Province I-ORG No. O 132300410274 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81301963 O This O work O was O supported O by O the O grants O from O Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG JCYJ20220530143406015 O JCYJ20210324121802008 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82204424 O the O Natural B-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG 2021R1001003 O 2021J011343 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2021M691895 O His O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 41504027 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG Grant O No. O 2017CFB520 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No. O 2042017kf0201 B-AWARD and O the O Basic B-ORG Scientific I-ORG Research I-ORG Projects I-ORG of I-ORG Liaoning I-ORG Higher I-ORG Education I-ORG Institutions I-ORG LJ2017FAL005 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81400857 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2021A1515011527 O and O the O Pearl B-ORG River I-ORG S&T I-ORG Nova I-ORG Program I-ORG of I-ORG Guangzhou I-ORG No. O 201610010093 O S.T O was O supported O by O EPSRC B-ORG DTG O doctoral O award O 1265509 B-AWARD M.W O M.C O and O D.H O were O supported O by O BBSRC B-ORG grants O BB/L006340/1 B-AWARD and O BB/M017982/1 B-AWARD B.F O was O supported O by O the O Medical B-ORG Research I-ORG Council O Grant O reference O MR/M013170/1 B-AWARD This O work O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81573748 O 81770668 B-AWARD The O study O was O sponsored O by O the O Program B-ORG of I-ORG Shanghai I-ORG Academic I-ORG Research I-ORG Leader I-ORG 16XD1401900 O as O well O as O by O a O grant O [2017]485 O from O the O Shanghai B-ORG Leadership I-ORG Training I-ORG Program I-ORG in I-ORG 2017 O The O funding O bodies O did O not O contribute O to O the O design O of O the O study O collection O analysis O and O interpretation O of O data O and O in O manuscript O writing O This O study O was O financially O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0905100 O the O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG CIFMS O 2016-I2M-1-002 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81571863 O 81871574 B-AWARD the O Key B-ORG Laboratory I-ORG of I-ORG craniofacial I-ORG congenital I-ORG malformation I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG 2018PT31051 O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 31960698 B-AWARD and O 31760732 B-AWARD the B-ORG Science I-ORG and I-ORG Technology I-ORG Fund I-ORG of I-ORG Guizhou I-ORG Province I-ORG Grant O Nos O QKHJ-2020-1Y134 B-AWARD the B-ORG Transformation I-ORG and I-ORG Industrialization I-ORG of I-ORG Scientific I-ORG and I-ORG Technological I-ORG Achievements I-ORG of I-ORG Guizhou I-ORG Province I-ORG Grant O No. O QKHKY-2017-055 B-AWARD and O the B-ORG Agricultural I-ORG Research I-ORG Project I-ORG of I-ORG Guizhou I-ORG Province I-ORG Grant O No. O QKHZC-2016-2588 B-AWARD The O authors O are O grateful O for O National O project O funding O for O Key B-ORG R I-ORG I-ORG D I-ORG programs I-ORG under O Grant O No. O 2018YFC0808500 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O No. O 51376088 B-AWARD Key B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O No. O 51834007 B-AWARD The O funder O provided O a O role O in O study O design O formal O analysis O and O publication O decisions O of O the O manuscript O We O thank O the O financial O support O from O NSFC-Guangdong B-ORG Joint I-ORG funding I-ORG China I-ORG No. O U1801256 O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFA0201002 O Guangdong B-ORG Provincial I-ORG Foundation I-ORG 2016KQNCX035 O NSFC B-ORG grant I-ORG No. O 51803064 I-AWARD 51571094 I-AWARD 51431006 I-AWARD 51561135014 I-AWARD U1501244 O Program B-ORG for I-ORG Chang I-ORG Jiang I-ORG Scholars I-ORG and I-ORG Innovative I-ORG Research I-ORG Teams I-ORG in I-ORG Universities I-ORG No. O IRT_17R40 O and O Guangdong B-ORG Innovative I-ORG Research I-ORG Team I-ORG Program I-ORG No. O 2013C102 O This O study O was O supported O by O the O Open B-ORG Projects I-ORG of I-ORG the I-ORG Discipline I-ORG of I-ORG Chinese I-ORG Medicine I-ORG of I-ORG Nanjing I-ORG University I-ORG of I-ORG Chinese I-ORG Medicine I-ORG Supported I-ORG by I-ORG the I-ORG Subject I-ORG of I-ORG Academic I-ORG priority I-ORG discipline I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O Grant O number O ZYX03KF047 B-AWARD the O Research B-ORG Foundation I-ORG of I-ORG Education I-ORG Bureau I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grant O number O 16KJA360001 B-AWARD Postgraduate B-ORG Research I-ORG I-ORG Practice I-ORG Innovation I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grant O number O KYCX19_1239 B-AWARD KYCX19_1227 O This O work O was O supported O by O grants O from O the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2014AA093515 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31300062 O the O Introduction B-ORG Project I-ORG of I-ORG Academic I-ORG and I-ORG Technology I-ORG Leaders I-ORG in I-ORG Anhui I-ORG University I-ORG 32030066 O National B-ORG Innovation I-ORG Experiment I-ORG Program I-ORG for I-ORG University I-ORG Students I-ORG 201510357026 O This O work O was O supported O by O Hawaiian B-ORG Community I-ORG Foundation I-ORG 16CON-78919 O and O National B-ORG Institute I-ORG of I-ORG Health I-ORG NIGMS I-ORG P20GM125508 O grants O to O Masato O Yoshizawa O and O a O National B-ORG Science I-ORG Foundation I-ORG award O DEB-1556819 B-AWARD to O Megan O L. O Porter O supported O this O research O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31670851 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC1306605 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG of I-ORG China I-ORG 18KJD520003 O This O work O was O supported O by O the O grants O from O Shanghai B-ORG Municipal I-ORG Education I-ORG Commission I-ORG for O promoting O public O health O in O students O No. O HJTY-2014-A10 B-AWARD and O the O Ministry B-ORG of I-ORG Education I-ORG of I-ORG Humanities I-ORG and I-ORG Social I-ORG Science I-ORG Project I-ORG No. O 17YJC890036 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81703252 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O CRACKIT23 B-ORG challenge I-ORG award I-ORG NC/CO16206/1 O European B-ORG Research I-ORG Council I-ORG #614620 B-AWARD MRC B-ORG Confidence I-ORG in I-ORG Concept I-ORG award I-ORG MC_PC_15030 O RP B-ORG Fighting I-ORG Blindness I-ORG Innovation I-ORG grant I-ORG GR584 O and I-AWARD GR585 O CRACKIT23 O award O to O Biosciences O Institute O Faculty O of O Medical O Sciences O Newcastle O University O UK. O provided O support O in O the O form O of O salaries O for O authors O MG, O BH, O VC, O but O did O not O have O any O additional O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O specific O roles O of O these O authors O are O articulated O in O the O ‘author O contributions’ O section O The O research O was O supported O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2572015CA17 O 2572014EA04 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31502013 O 31170368 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG C2015060 O and O Open B-ORG Project I-ORG Program I-ORG of I-ORG the I-ORG Key I-ORG Laboratory I-ORG of I-ORG Vegetation I-ORG Ecology I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG Northeast I-ORG Normal I-ORG University I-ORG 130026529 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O O 81872685 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG Grant O O 2017JJ3215 B-AWARD and O Open O Project O of O Key B-ORG Laboratory I-ORG of I-ORG Environmental I-ORG Pollution I-ORG Monitoring I-ORG and I-ORG Disease I-ORG Control I-ORG Guizhou I-ORG Medical I-ORG University I-ORG Grant O GMU-2017-HJZ-05 O None O of O the O funding O that O we O had O received O plays O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O supported O by O the O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG XDA0810405 O FEBL B-ORG Program I-ORG 2016FBZ05 O and O MOST B-ORG 973 I-ORG Project I-ORG 2010CB126305 O of O China O This O work O was O financially O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hainan I-ORG 322MS131 O 220RC702 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41776093 O and O Financial B-ORG Fund I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Agriculture I-ORG and I-ORG Rural I-ORG Affairs I-ORG P. I-ORG R. I-ORG China I-ORG NFZX2023 O This O work O was O supported O by O Shandong B-ORG Excellent I-ORG Young I-ORG Scientist I-ORG Award I-ORG Fund I-ORG BS2014YY031 O Foundation B-ORG of I-ORG University I-ORG of I-ORG Jinan I-ORG XBS1519 O XKY1324 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31100088 O 31300045 B-AWARD 51208290 B-AWARD 31372356 B-AWARD Shandong B-ORG province I-ORG science I-ORG and I-ORG technology I-ORG development I-ORG plan I-ORG 2013GSF12006 O A O Project B-ORG of I-ORG Shandong I-ORG Province I-ORG Higher I-ORG Educational I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG YE13 O Open B-ORG Foundation I-ORG of I-ORG Xinjiang I-ORG Production I-ORG I-ORG Construction I-ORG Corps I-ORG Key I-ORG Laboratory I-ORG of I-ORG Protection I-ORG and I-ORG Utilization I-ORG of I-ORG Biological I-ORG Resources I-ORG in I-ORG Tarim I-ORG Basinand I-ORG BYBR1405 O BRYB1501 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the B-ORG Doctor I-ORG Launch I-ORG Fund I-ORG of I-ORG Guangdong I-ORG Provincial I-ORG People's I-ORG hospital I-ORG grant O number O 2020bq11 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grants O 82002928 B-AWARD 81902828 B-AWARD 81602645 B-AWARD 81071851 B-AWARD 81001189 B-AWARD National O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG Grant O 2016A030313768 B-AWARD 2018A030313292 B-AWARD Medical B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG B2019039 O Bo O Chen O Research B-ORG Funds I-ORG from I-ORG Guangzhou I-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 201707010418 O 201804010430 B-AWARD This O work O was O supported O by O grants O from O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. I-AWARD 2018YFC1105800 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. I-AWARD 81671841 O and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No. I-AWARD 22221818014 O This O study O was O funded O by O the O Science O and O Technology O Plan O Project O of O the O Henan B-ORG Provincial I-ORG Department I-ORG of I-ORG Housing I-ORG and I-ORG Urban-Rural I-ORG Development I-ORG HNJS-2022-K44 O the O Opening O Foundation O of O the O Henan B-ORG Key I-ORG Laboratory I-ORG of I-ORG Grain I-ORG and I-ORG Oil I-ORG Storage I-ORG Facility I-ORG and I-ORG Safety I-ORG 2021KF-B05 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 2020JM-230 O This O work O was O financially O supported O by O the B-ORG earmarked I-ORG fund I-ORG for I-ORG Modern I-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG CARS-37 O the B-ORG Agricultural I-ORG Research I-ORG Center I-ORG at I-ORG Washington I-ORG State I-ORG University I-ORG College I-ORG of I-ORG Agricultural I-ORG Human I-ORG and I-ORG Natural I-ORG Resource I-ORG Sciences I-ORG 17A-3019-8663 O Washington B-ORG Grain I-ORG Commission I-ORG 126593 O China B-ORG Scholarship I-ORG Council I-ORG 201406350114 O and O the B-ORG Program I-ORG for I-ORG Changjiang I-ORG Scholar I-ORG and I-ORG Innovation I-ORG Research I-ORG Team I-ORG in I-ORG University I-ORG IRT1191 O Beijing O Sunlon O Livestock O Development O Co. O Ltd O provided O support O in O the O form O of O salaries O for O authors O GG, O GD, O and O XL O and O assisted O in O measurement O and O data O collection O for O this O study O The O funder O had O no O additional O role O in O study O design O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O byThe O Alzheimer's I-ORG Society[Grant O numbers O AS-PG-2013-005 B-AWARD AS-JF-16b-004 B-AWARD 510)],ARUK[Grant O number O ARUK-PPG2017A-7],10.13039/501100000406Motor B-AWARD Neurone I-ORG Disease I-ORG Association[Grant O number O Sweeney/Oct15/884-792 B-AWARD and10.13039/100010269Wellcome O Trust[Grant O number O 204829 B-AWARD This O research O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 71673116 B-AWARD to O XF, O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O SBK2015021674 B-AWARD to O JY, O and O the O Humanistic B-ORG and I-ORG Social I-ORG Science I-ORG Foundation I-ORG from I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG Grant O 16YJAZH007 B-AWARD to O XF. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq O 140224/2013-0 B-AWARD Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG do I-ORG Rio I-ORG de I-ORG Janeiro I-ORG FAPERJ O E-26/110.168/2014 B-AWARD Instituto O Nacional O de O Ciência O e O Tecnologia O em O Entomologia O Molecular O INCT O and O the O National B-ORG Institue I-ORG of I-ORG Health I-ORG NIH O UO1 B-AWARD AI115595 O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O No. O 51205212 B-AWARD Natural B-ORG Science I-ORG Fund I-ORG of I-ORG Jiangsu I-ORG Province I-ORG of I-ORG China I-ORG under O Grant O No. O BK2012233 B-AWARD Nantong B-ORG City I-ORG Applied I-ORG Basic I-ORG Research I-ORG Project I-ORG JC22022074 O and O Instruments B-ORG and I-ORG Equipment I-ORG Open I-ORG Fund I-ORG of I-ORG Nantong I-ORG University I-ORG KFJN2235 O The O current O research O was O supported O by O the O Open B-ORG Fund I-ORG of I-ORG Anhui I-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Local I-ORG Animal I-ORG Genetic I-ORG Resources I-ORG Conservation I-ORG and I-ORG Biobreeding I-ORG AKLGRCB2017008 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Province I-ORG 1808085QC61 O Programs O for O the O Key B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Anhui I-ORG Province I-ORG 1704a07020091 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Research O was O supported O by O research O grants O from O the O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq;http://cnpq.br O Brazil O 590106/2011-2 O to O MUF O the O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo I-ORG FAPESP;http://www.fapesp.br O Brazil O 2010/51835-7 O to O MUF O and O the O National B-ORG Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases I-ORG NIAID O National O Institutes O of O Health O NIH;https://www.niaid.nih.gov O USA O International O Centers O of O Excellence O in O Malaria O Research O ICEMR O program O U19 B-AWARD AI089681 I-AWARD to O Joseph O M. O Vinetz O University O of O California O San O Diego O PTR O was O supported O by O a O scholarship O from O CNPq O which O also O provided O a O senior O researcher O scholarship O to O MUF O RMG-L O 2010/51938-0 O NFL O 2013/26928-0 O and O SB O 2013/23770-6 O were O supported O by O scholarships O from O FAPESP O and O TCO O was O supported O by O a O scholarship O from O the O Coordenação O de O Aperfeiçoamento O de O Pessoal O de O Nível O Superior O CAPES;http://www.capes.gov.br O Brazil O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O in O part O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31701114 B-AWARD G. O Wan O 81602972 B-AWARD X. O Xiong O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017A010105004 B-AWARD X. O Wu O 2017A010103009 B-AWARD 2017B020227009 B-AWARD B. O Wei O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG University-Key I-ORG Cultivation I-ORG Project I-ORG of I-ORG Young I-ORG Teacher I-ORG in I-ORG Sun I-ORG Yat-Sen I-ORG University I-ORG 17ykzd11 B-AWARD G. O Wan O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 16ykjc23 B-AWARD B. O Wei O The O funders O were O not O involved O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32201491 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2021M690847 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG of I-ORG China I-ORG 21KJB220011 O the O science B-ORG and I-ORG technology I-ORG innovation I-ORG Program I-ORG of I-ORG Hunan I-ORG Province I-ORG 2021RC2106 O Deputy B-ORG General I-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Jiangsu I-ORG Province I-ORG FZ20211507 O Innovation B-ORG Training I-ORG Program I-ORG for I-ORG College I-ORG students I-ORG of I-ORG Nanjing I-ORG Forestry I-ORG University I-ORG 202110298118H O Hunan B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 2022JJ40007 O Jiangsu B-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Fund I-ORG CX(22)3047 O Funding O for O this O project O has O been O provided O in O part O by O Nestlé O Purina O to O pay O for O personnel O salaries O and O sequencing O W.C.W O and O R.M O Wisdom O Health O unit O of O Mars O Veterinary O to O pay O for O personnel O salaries O L.A.L O Zoetis O to O pay O for O RNA O sequencing O used O in O annotation O L.A.L O the O University O of O Missouri O College O of O Veterinary O Medicine O Gilbreath-McLorn O endowment O was O used O for O the O BioNano O optical O map O L.A.L O and O Winn B-ORG Feline I-ORG Foundation I-ORG W15-008 B-AWARD W.J.M O Winn B-ORG Feline I-ORG Foundation/Miller I-ORG Trust I-ORG MT14-009 B-AWARD W.J.M O https://www.winnfelinefoundation.org O and O Morris B-ORG Animal I-ORG Foundation I-ORG D16FE-011 B-AWARD W.J.M O https://www.morrisanimalfoundation.org O were O all O used O for O PacBio O sequencing O The O funders O had O no O role O in O study O design O data O collection O data O analysis O interpretation O of O results O or O decision O to O publish O This O work O is O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81803664 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M630902 O Program B-ORG of I-ORG Survey I-ORG and I-ORG Monitoring I-ORG of I-ORG Chinese I-ORG Medicines I-ORG for I-ORG National I-ORG Drugs I-ORG [2017 O 66 O China O Hunan O Provincial O Science O O Technology O Department O 2016SK3001 O Program O of O Standardization O ofPoria O cocos(ZYBZH-Y-HUN-22 O and O key O project O at O central O government O level O for O the O ability O establishment O of O sustainable O use O for O valuable O Chinese O medicine O resources O 2060302 O This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0100400 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31601385 O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG 2016ZX08012-002 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20160429 O and I-AWARD BK20180107 O European B-ORG Union's I-ORG Horizon I-ORG 2020 I-ORG research I-ORG and I-ORG innovation I-ORG programme I-ORG under O grant O agreement O 634890 O Engineering B-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG through O a O Healthcare O Technologies O Challenge O Award O RKN O EP/N020901/1 O Physical B-ORG Sciences I-ORG for I-ORG Health I-ORG Centre I-ORG for I-ORG Doctoral I-ORG Training I-ORG NW) O EP/L016346/1 O Funding O for O open O access O charge O University O of O Birmingham O This O work O was O financially O supported O by O the O earmarked O fund O for O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-14 O the O Key B-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG in I-ORG Henan I-ORG Province I-ORG 151100111200 O and O Science-Technology B-ORG Foundation I-ORG for I-ORG Outstanding I-ORG Young I-ORG Scientists I-ORG of I-ORG Henan I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG 2013YQ27 O Authors O declare O that O none O of O the O funding O bodies O have O any O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O as O well O as O in O writing O the O manuscript O This O report O presents O independent O research O commissioned O and O funded O by O the O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG NIHR I-ORG Policy I-ORG Research I-ORG Programme O conducted O through O the O Policy O Research O Unit O in O Cancer O Awareness O Screening O and O Early O Diagnosis O PR-PRU-1217-21601 B-AWARD The O views O expressed O are O those O of O the O authors O and O not O necessarily O those O of O the O NIHR O the O Department O of O Health O and O Social O Care O or O its O arm’s-length O bodies O or O other O government O departments O This O study O is O also O relates O to O the O NIHR B-ORG Programme I-ORG Grants I-ORG for I-ORG Applied I-ORG Research I-ORG PGfAR I-ORG SPOtting I-ORG Cancer I-ORG among I-ORG Comorbidities I-ORG SPOCC O programme O supporting O clinical O decision O making O in O patients O with O symptoms O of O cancer O and O pre-existing O conditions O NIHR201070 O GL O is O supported O by O Cancer B-ORG Research I-ORG UK I-ORG Advanced O Clinician O Scientist O Fellowship O 18081/A18180 B-AWARD CR O acknowledges O funding O from O Cancer B-ORG Research I-ORG UK-Early I-ORG Detection I-ORG and I-ORG Diagnosis I-ORG Committee I-ORG grant O number O EDDCPJT\100018 B-AWARD This O work O was O supported O by O the O program O for O Brain O Mapping O by O Integrated O Neurotechnologies O for O Disease O Studies O from O the O Japan B-ORG Agency I-ORG for I-ORG Medical I-ORG Research I-ORG and I-ORG Development I-ORG Grant O Number O JP21dm0207001 B-AWARD to O HO O Japan B-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG Grant O Number O JP20H03630 B-AWARD to O JH O and O “MRI O platform” O as O a O program O of O Project O for O Promoting O Public O Utilization O of O Advanced O Research O Infrastructure O of O the O Ministry B-ORG of I-ORG Education I-ORG Culture I-ORG Sports I-ORG Science I-ORG and I-ORG Technology I-ORG Japan I-ORG Grant O Number O JPMXS0450400622 B-AWARD This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31871710 O and O 31971946 B-AWARD the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG S2022ZD03 O and O the O Chinese B-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG in I-ORG China I-ORG 2060302-2-19 O This O research O was O supported O in O part O by O the O European B-ORG Research I-ORG Council I-ORG ERC O through O Starting O Grant O BEACON O Agreement O No. O 677854 B-AWARD by O the O U.K O Engineering B-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG EPSRC O through O the O project O COPES O EP/N021738/1 O and O by O the O British B-ORG Council I-ORG Institutional O Link O Program O under O Grant O NO. O 173605884 B-AWARD This O research O was O supported O by O Heilongjiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG C2018004 O to O HW, O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31100470 O to O ZW, O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2572015CA14 O to O HW. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O is O supported O by O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG under O grant O 62063011 B-AWARD the O Yunnan B-ORG Major I-ORG Scientific I-ORG and I-ORG Technological I-ORG Projects I-ORG under O grant O 202202AG050002 B-AWARD and O the O Open B-ORG Foundation I-ORG of I-ORG Key I-ORG Laboratory I-ORG in I-ORG Software I-ORG Engineering I-ORG of I-ORG Yunnan I-ORG Province I-ORG under O grant O no. O 2020SE502 B-AWARD This O research O was O funded O by O the O Japan B-ORG Agency I-ORG for I-ORG Medical I-ORG Research I-ORG and I-ORG Development I-ORG grant O numbers O 16dk0110018h0001 B-AWARD 17dk0110018h0002 B-AWARD and O 18dk0110018h0003 B-AWARD JSPS B-ORG KAKENHI I-ORG grant O numbers O 16K11907 B-AWARD 19K19342 B-AWARD 20H03903 B-AWARD and O 22K17296 B-AWARD and O MHLW B-ORG GA I-ORG Program I-ORG grant O number O 20GA1003 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31802069 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0500505 O and O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2019M662270 O This O work O was O sponsored O by O Innovation B-ORG Foundation I-ORG for I-ORG Doctor I-ORG Dissertation I-ORG of I-ORG Northwestern I-ORG Polytechnical I-ORG University I-ORG Grant O No. B-AWARD CX201829 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. B-AWARD 51775443 O and O the O 111 B-ORG Project I-ORG Grant O No. B-AWARD B13044 O This O work O was O financially O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.31670975 O the B-ORG Research I-ORG Project I-ORG of I-ORG Shaanxi I-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Biotechnology I-ORG No. O 14JS088 O and O the B-ORG Project I-ORG Serving I-ORG the I-ORG local I-ORG Shaanxi I-ORG Provincial I-ORG Education I-ORG Department I-ORG No. O 15JF032 O The O funding O bodies O had O no O roles O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O study O was O funded O by O several O grants O showed O as O follow O Cooperation B-ORG Project I-ORG Between I-ORG Lanzhou I-ORG University I-ORG and I-ORG Jinchuan I-ORG Nonferrous I-ORG Metals I-ORG Corporation I-ORG No. B-AWARD JKB20120013 O National O Major O Special O Project O of O Cancer O Screening O Program O in O Urban O Area O of O China O National O Health O Commission O of O People’s O Republic O of O China O CanSPUC O No. O CZB20120064 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81673248 O The O Fundamental O Research O Funds O for O the O Central O Universities O No.lzujbky-2017-k04 O Also O the O author O was O sponsored O by O the O China B-ORG Scholarship I-ORG Council I-ORG No. O 20160618 O as O a O joint O Ph.D O student O studied O at O Yale O University O and O Lanzhou O University O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31870837 O the O Scientific O Research O Grant O of O Ningbo B-ORG University I-ORG 215-432000282 O and O the O Ningbo B-ORG Top I-ORG Talent I-ORG Project I-ORG 215-432094250 O This O work O was O supported O by O the O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 82170854 B-AWARD 82100901 B-AWARD 81870579 B-AWARD 81870545 B-AWARD 81570715 B-AWARD 81170736 B-AWARD Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 7202163 O Beijing B-ORG Municipal I-ORG Science I-ORG I-ORG Technology I-ORG Commission I-ORG Z201100005520011 O National B-ORG High I-ORG Level I-ORG Hospital I-ORG Clinical I-ORG Research I-ORG Funding I-ORG 2022-PUMCH-C-019 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC2001100 O and O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG CIFMS2021-1-I2M-002 O CIFMS2017-I2M-1-008 B-AWARD This O research O was O supported O by O The B-ORG Xiamen I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG 3502Z20164020 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG 2018J01153‚ O 2019J01551 B-AWARD The B-ORG Project I-ORG Funding I-ORG for I-ORG the I-ORG Training I-ORG of I-ORG Young I-ORG Talents I-ORG in I-ORG the I-ORG Health I-ORG System I-ORG of I-ORG Fujian I-ORG Province I-ORG 2014-ZQNJC-42 O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2013B022000069 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 8187111677 O This O study O was O supported O by O the O Leading B-ORG Project I-ORG Foundation I-ORG of I-ORG Science I-ORG Department I-ORG of I-ORG Fujian I-ORG Province I-ORG 2018N0022 O the O Major B-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Fujian I-ORG Province I-ORG China I-ORG 2019NZ09005 O and O the O Fujian B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Fujian I-ORG Province I-ORG China I-ORG 2016J01168 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31500070 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20150136 O BK20150151 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG JUSRP51705A O This O work O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFA0201001 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 11627801 O and I-AWARD 51675174 O and O Scientific B-ORG Research I-ORG Fund I-ORG of I-ORG Hunan I-ORG Provincial I-ORG Education I-ORG Department I-ORG 16A202 O and I-AWARD 16C0626 O This O study O was O supported O by O funds O from O the O National B-ORG Institute I-ORG of I-ORG Arthritis I-ORG and I-ORG Musculoskeletal I-ORG and I-ORG Skin I-ORG Diseases I-ORG award O number O F32 B-AWARD AR067050 I-AWARD AGM O and O the O National B-ORG Institute I-ORG of I-ORG Neurological I-ORG Disorders I-ORG and I-ORG Stroke I-ORG award O number O P01 B-AWARD NS069539 I-AWARD SJT O SMvdM O of O the O National O Institutes O of O Health O the O Prinses B-ORG Beatrix I-ORG Spierfonds I-ORG W.OP14-01 O SMvdM O and O the O European B-ORG Union’s I-ORG Seventh I-ORG Framework I-ORG Program I-ORG IDEAL I-ORG FP7/2007-2011 O BTH O under O grant O agreement O no. O 259679 B-AWARD This O research O was O funded O by O The B-ORG Spanish I-ORG Nuclear I-ORG Safety I-ORG Council I-ORG 2696/SRO O I.L O was O supported O by O a O Fellowship O of O the O ‘University O Junior O International O Entrepreneurs’ O program O UJIE O 2019 O of O University B-ORG of I-ORG Valencia I-ORG and I-ORG Generalitat I-ORG Valenciana O N.S.O O was O supported O by O the O Universidad B-ORG de I-ORG Alicante O Ministerio O de O Universidades O and O the O European O Union O “NextGeneration O EU/PRTR” O through O 2022–2024 O Margarita O Salas O grant O MARSALAS22-23 O This O research O was O supported O by O ALiCE B-ORG LA/P/0045/2020 O and O LSRE-LCM B-ORG UIDB/50020/2020 O and O UIDP/50020/2020 B-AWARD funded O by O national B-ORG funds I-ORG through I-ORG FCT/MCTES I-ORG PIDDAC O Pedro O Velho O is O grateful O for O the O funding O support O from O FCT O 2021.06626.BD O This O work O was O supported O by O the O Heilongjiang B-ORG Natural I-ORG Science I-ORG Foundation I-ORG C2017039 O the O Project O of O Heilongjiang B-ORG Education I-ORG Department I-ORG 12531178 O Fundamental O Research O Funds O for O the O Heilongjiang B-ORG Provincial I-ORG Universities I-ORG KJCXZD201717 O and O the O PhD B-ORG Research I-ORG Fund I-ORG XKB201914 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O has O been O conducted O thanks O to O the O support O of O Projects O PID2020-116002RB-100/AEI/10.13039/501100011033 B-AWARD HORRADIONEX O and O PDC2021-120771-I00/AEI/10.13039/501100011033/European B-AWARD Union I-ORG Next I-ORG Generation I-ORG EU/PRTR I-ORG REVERDECE O The O authors O would O also O like O to O thank O the O MICIM B-ORG for I-ORG the I-ORG pre-doctoral I-ORG contract I-ORG PRE2021-098535 O of O Andrés O Caño O Blanes O and O the O government O of O the O Autonomous B-ORG Community I-ORG of I-ORG Madrid I-ORG for I-ORG the I-ORG Contrato I-ORG de I-ORG Garantía I-ORG Juvenil O PEJ-2020-TL/AMB-19344 O of O Queralt O Belen O Marzal O This O study O was O supported O by O the B-ORG Qingdao I-ORG Startup I-ORG and I-ORG Innovation I-ORG Leader I-ORG Talent I-ORG Plan O 13-CX-3 B-AWARD 201409-201709 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O 81472542 B-AWARD the B-ORG Chinese I-ORG Medicine I-ORG Projects I-ORG in I-ORG Shandong I-ORG Province O 2021Z036 B-AWARD the B-ORG Key I-ORG research I-ORG and I-ORG development I-ORG project I-ORG of I-ORG Shandong I-ORG Province O 2019GSF107025 B-AWARD This O study O is O supported O by O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG Grant O No. O 2013B051000035 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 81571926 B-AWARD 81401628 B-AWARD 81372090 B-AWARD 81772127 B-AWARD 81500493 B-AWARD Guangzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Grant O Nos O 201508030003 B-AWARD and O 201607010233 B-AWARD Outstanding B-ORG Young I-ORG Teacher I-ORG Training I-ORG Program I-ORG of I-ORG Sun I-ORG Yat-sen I-ORG University O China O Grant O No. O 17ykpy55 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG Grant O No. O 2015A030313098 B-AWARD JWP O received O funding O from O National B-ORG Institutes I-ORG of I-ORG Health I-ORG 5R01GM112697-02 O https://www.nih.gov O John B-ORG Templeton I-ORG Foundation I-ORG #48503 O https://templeton.org O and O National B-ORG Science I-ORG Foundation I-ORG IIS-1344257 O https://www.nsf.gov O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O IMI-EU B-ORG HARMONY I-ORG grant O number O 116026 B-AWARD and O 945406 B-AWARD to O G.C O by O EU B-ORG Horizon I-ORG 2020 I-ORG programme I-ORG GenoMed4All I-ORG grant O number O 101017549 B-AWARD to O G.C O and O by O the O AIRC B-ORG Foundation I-ORG Associazione I-ORG Italiana I-ORG per I-ORG la I-ORG Ricerca I-ORG contro I-ORG il I-ORG Cancro I-ORG Milan I-ORG Italy O grant O number O 26216 B-AWARD to O G.C O This O work O is O funded O by O Barrow B-ORG Neurological I-ORG Foundation I-ORG 4003032226 O the O Flinn B-ORG Foundation I-ORG 2190 O the B-ORG National I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81671050 O This O research O was O supported O by O Korea O Institute O of O Science B-ORG and I-ORG Technology I-ORG Future I-ORG Resource I-ORG Program I-ORG 2E29400 O and O was O sponsored O by O China B-ORG Scholarship I-ORG Council I-ORG 201808260042 O Furthermore O the O financial O supports O of O the O Future B-ORG Material I-ORG Discovery I-ORG Program I-ORG 2016M3D1A1027666 O and O the O Basic B-ORG Science I-ORG Research I-ORG Program I-ORG 2017R1A2B3009135 O through O the O National O Research O Foundation O of O Korea O are O appreciated O This O work O was O supported O by O grants O from O the O National B-ORG Laboratory I-ORG of I-ORG HIRFL I-ORG 2016-HIRFL-ZD-00095 O 2016-HIRFL-ZD-00014 I-AWARD and I-AWARD 2017-HIRFL-ZD-000770 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 11105193 B-AWARD the O CAS B-ORG Light I-ORG of I-ORG West I-ORG China I-ORG Talent I-ORG Training I-ORG Programme I-ORG Ke-Fa-Ren-Zi O 2015 I-AWARD No. I-AWARD 77 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Gansu I-ORG Provincial I-ORG Sci I-ORG and I-ORG Tech I-ORG Department I-ORG No. O 1506RJZA293 B-AWARD and O the O National B-ORG Major I-ORG Scientific I-ORG and I-ORG Technological I-ORG Special I-ORG Project I-ORG for I-ORG “Significant I-ORG New I-ORG Drugs I-ORG Development” I-ORG No. O 2017ZX09101002-003-001 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Basic I-ORG Survey I-ORG Project I-ORG 2017FY101302 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 71373170 O and O 61673085 B-AWARD the O Shanxi B-ORG Postgraduate I-ORG Teaching I-ORG Reform I-ORG Project I-ORG SD18100402 O and O the O Shanxi B-ORG Planning I-ORG Office I-ORG of I-ORG Philosophy I-ORG and I-ORG Social I-ORG Sciences I-ORG 2019B091 O The O research O was O partially O supported O by O the O Russian B-ORG Science I-ORG Foundation I-ORG Grant O №16-13-00053 O and O the O Ministry B-ORG of I-ORG Education I-ORG and I-ORG Science I-ORG of I-ORG the I-ORG Republic I-ORG of I-ORG Kazakhstan I-ORG Project O No. O AP05130148 B-AWARD The O education O activity O of O Ph.D O and O students O involved O into O this O work O is O supported O by O Act O 211 O of O Government B-ORG of I-ORG the I-ORG Russian I-ORG Federation O agreement O No. O 02.A03.21.0006 B-AWARD This O study O is O supported O by O the B-ORG China I-ORG International I-ORG Food I-ORG and I-ORG Medicine I-ORG Exchange I-ORG Center I-ORG of I-ORG NMPA I-ORG Commissioned I-ORG Research I-ORG Project I-ORG “International I-ORG Publicity I-ORG on I-ORG the I-ORG Safety I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine” I-ORG Z0531 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Public I-ORG Welfare I-ORG Research I-ORG Institutes I-ORG Z0546 O Scientific B-ORG Research I-ORG Innovation I-ORG Team I-ORG Project I-ORG of I-ORG China I-ORG Academy I-ORG of I-ORG Chinese I-ORG Medical I-ORG Sciences I-ORG PY1303 O Research B-ORG Project I-ORG of I-ORG Postgraduate I-ORG Education I-ORG and I-ORG Teaching I-ORG Reform I-ORG of I-ORG China I-ORG Academy I-ORG of I-ORG Chinese I-ORG Medical I-ORG Sciences I-ORG JG201703 O The O funders O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O D010202 B-AWARD the O Youth B-ORG Program I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 41701426 B-AWARD Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O ZR2017BD030 B-AWARD and O Hebei B-ORG Provincial I-ORG Education I-ORG Science I-ORG Planning I-ORG Project I-ORG No. O 2202008 B-AWARD This O research O was O supported O by O the O New B-ORG Liberal I-ORG Arts I-ORG Research I-ORG and I-ORG Reform I-ORG Practice I-ORG Project I-ORG of I-ORG Henan I-ORG Province I-ORG 2021JGLX068&2021JGLX070 O Philosophy B-ORG and I-ORG Social I-ORG Science I-ORG Planning I-ORG Project I-ORG of I-ORG Henan I-ORG Province I-ORG 2022BJJ069 O and O National B-ORG Social I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21BJY016 O This O work O was O funded O by O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDA24010308-2 O a O grant O from O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2022YFF1000302 O and O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 31972826 O and O 32102838 B-AWARD We O acknowledge O the O support O of O the O Agricultural O Experiment O Station O Hatch O Project O grant O no. O CA-R-PPA-6689-H B-AWARD the B-ORG US I-ORG National I-ORG Science I-ORG Foundation I-ORG grant O nos O EF-0410408 B-AWARD CRR-0120778 B-AWARD and O DEB-1442537 O the O Japan B-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG JSPS O Institutional O Program O for O Young O Researchers O on O Overseas O Visits O and O the O JSPS O KAKENHI O grant O nos O 24780151 B-AWARD and O 16H06196 B-AWARD We O also O thank O Dr. O Jan O Colpaert O and O two O anonymous O reviewers O for O their O valuable O comments O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O U1806201 O 61671261 B-AWARD 61431004 I-AWARD 61771271 O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG No. O 2016GGX101007 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2017T100490 B-AWARD the O University O Science O and O Technology O Planning O Project O of O Shandong O Province O No. O J17KA058 B-AWARD J17KB154 O the O Natural O Science O Foundation O of O ShanDong O Province O No. O ZR2017BF036 O and O the O Applied O Basic O Research O Projects O of O QingDao O No. O 17-1-1-4-jch O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31771246 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG 2018YFC0831101 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG SZU I-ORG 000174 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O current O study O was O supported O by O grant O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81573206 O Yunnan B-ORG Applied I-ORG Basic I-ORG Research I-ORG Projects I-ORG 2016FA034 O The B-ORG PUMC I-ORG Youth I-ORG Fund I-ORG 3332019111 O Special B-ORG Funds I-ORG for I-ORG High-level I-ORG Healthy I-ORG Talents I-ORG of I-ORG Yunnan I-ORG Province I-ORG D-201669 O and O L-201615 B-AWARD CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG 2016-I2M-2-001 O Yunnan O Provincial O Science O and O Technology O Department O 2019HC0060 O Association O Foundation O Program O of O Yunnan O Provincial O Science O and O Technology O Department O and O Kunming O Medical O University O 2017FR467–077 O and O 2017FE467–012 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Funding O was O provided O by O the O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG MOP-130269 O PTJ-148535 B-AWARD and O PTJ-153330 B-AWARD PI: O LB O The O National B-ORG Institutes I-ORG of I-ORG Health I-ORG R01 O NS115845 I-AWARD and O R25 B-AWARD HD105583 O PI: O S-LL O The O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG GNT1020526 O GNT1045617 B-AWARD and O GNT1094974 B-AWARD PI: O AB O Brain O Foundation O Wicking O Trust O Collie O Trust O Sidney O and O Fiona O Myer O Family O Foundation O and O National O Heart O Foundation O Future O Leader O Fellowship O 100,784 O PI: O AB O Study O funders O had O no O role O in O study O design O data O collection O analysis O interpretation O or O manuscript O writing O This O project O was O funded O by O the O Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG ZR2017MD031 O Liaoning B-ORG BaiQianWan I-ORG Talents I-ORG Program I-ORG No. O 2014Q110 B-AWARD and O Research B-ORG Fund I-ORG of I-ORG Shandong I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2015TDJH101 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O NSFC-Henan B-ORG joint I-ORG grant I-ORG U1804107 O the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-40-K04 O the O Program B-ORG for I-ORG Innovation I-ORG Research I-ORG Team I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG IRT16R23 O and O the O Key B-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Project I-ORG of I-ORG Henan I-ORG Province I-ORG 151100110800 O This O research O is O partially O supported O by O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O No: O 7172251 B-AWARD and O National B-ORG Socical I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O No: O 13AYY004 B-AWARD and O General B-ORG Programs I-ORG funded I-ORG in I-ORG China-Japan I-ORG Friendship I-ORG Hospital I-ORG grant O No: O 2015-1-MS-5 B-AWARD and O Projects O funded O in O China B-ORG Rehabilitation I-ORG Research I-ORG Center I-ORG for I-ORG Hearing I-ORG and I-ORG Speech I-ORG Impairment I-ORG grant O No: O 201404 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript.The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the B-ORG Young I-ORG Scientists I-ORG Fund I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41506178 O the O National O Natural O Science O Foundation O of O China O 81673348 O and O the B-ORG National I-ORG Major I-ORG Scientific I-ORG and I-ORG Technological I-ORG Special I-ORG Project I-ORG for I-ORG “Significant I-ORG New I-ORG Drugs I-ORG Development” I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2013ZX09J13110-07B O This O work O was O supported O by O the O Norwegian B-ORG Veterinary I-ORG Institute I-ORG project O number O 12081 B-AWARD Norwegian B-ORG University I-ORG of I-ORG Life I-ORG Sciences I-ORG project O number O 1351051009 B-AWARD and O Norwegian B-ORG Environment I-ORG Agency I-ORG project O number O 3201040004 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Program O No. O 81603418 B-AWARD the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG Program O No. O H2016062 B-AWARD and O the B-ORG University I-ORG Nursing I-ORG Program I-ORG for I-ORG Young I-ORG Scholars I-ORG with I-ORG Creative I-ORG Talents I-ORG in I-ORG Heilongjiang I-ORG Province I-ORG Program O No. O UNPYSCT-2016075 B-AWARD and O the O First O Affiliated O Hospital O of O Harbin O Medical O University O Science O Research O Funds O Program O No. O 2017Y014 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51872300 O and I-AWARD U1832110 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG BX20190338 O and O the O W. B-ORG C. I-ORG Wong I-ORG Education I-ORG Foundation I-ORG rczx0800 O for O financially O supporting O this O work O The O authors O would O also O like O to O sincerely O thank O Qing O Huang O at O NIMTE O Qiang O Zhao O at O Nanjing O University O of O Posts O and O Telecommunications O NJUPT O for O allowing O us O accessing O the O fluorescence O spectrophotometer O and O photoluminescence O spectrometer O in O their O labs O and O thank O Feiyang O Li O at O NJUPT O helped O to O measure O the O FL O and O RTP O decay O spectra O This O study O was O funded O by O the B-ORG independent I-ORG project I-ORG of I-ORG Institute I-ORG of I-ORG Basic I-ORG Research I-ORG in I-ORG Clinical I-ORG Medicine I-ORG China I-ORG Academy I-ORG of I-ORG Chinese I-ORG Medical I-ORG Sciences I-ORG nos O Z0603 B-AWARD the B-ORG independent I-ORG project I-ORG of I-ORG China I-ORG Academy I-ORG of I-ORG Chinese I-ORG Medical I-ORG Sciences I-ORG nos.201904 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81230086 B-AWARD and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG for I-ORG Young I-ORG Scholars I-ORG of I-ORG China I-ORG No. O 81001583 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O byWellcome O Trust[grant O numbers O WT091681MA B-AWARD received O by O TDG O and O WT092606AIA B-AWARD received O by O CIP O and O YK];U.K O Biotechnology I-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council[grant O number O BB/J009849/1 B-AWARD received O by O CIP O and O YK, O joint O with O Quoc O Vuong O NPO O NeuroCreative O Lab O award O received O by O YK; O National B-ORG Institutes I-ORG of I-ORG Health I-ORG intramural O contract O received O by O CIP O and O YK; O NIH O extramural O grant O theNational O Institutes O of O Health[grant O number O R01-DC04290 B-AWARD received O by O Matthew O Howard O III O joint O with O TDG O and O CIP O This O work O was O supported O by O grant O number O RTI2018-094652-B-I00 B-AWARD funded O by O Ministerio B-ORG de I-ORG Ciencia I-ORG e I-ORG Innovación I-ORG and O Agencia B-ORG Estatal I-ORG de I-ORG Investigación O MCIN/AEI/10.13039/501100011033 B-AWARD and O by O “European O Regional O Development O Fund O ERDF O A O way O of O making O Europe” O and O by O grant O Proyecto O Intramural O 202340E012 B-AWARD funded O by O Consejo B-ORG Superior I-ORG de I-ORG Investigaciones I-ORG Científicas I-ORG CSIC O The O work O was O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0101900 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31672164 O Agriculture B-ORG and I-ORG Rural I-ORG Affairs I-ORG Commission I-ORG of I-ORG Shanghai I-ORG municipality I-ORG Agriculture O Applied O Technology O Development O Program O HuNongKeGong B-AWARD Grant I-AWARD No. I-AWARD 2015-6-1-7 O This O work O was O supported O by O grants O from O the B-ORG Chinese I-ORG National I-ORG Science I-ORG Foundation I-ORG Projects I-ORG 81372669 O 31470800 B-AWARD and O 31270867 B-AWARD the B-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Liaoning I-ORG province I-ORG China I-ORG 2012225020 O and O the B-ORG Project I-ORG of I-ORG Chinese I-ORG Ministry I-ORG of I-ORG Health I-ORG W2012RQ23 O This O work O was O supported O by O the O Japan B-ORG Ministry I-ORG of I-ORG Education I-ORG Culture I-ORG Sports I-ORG Science I-ORG and I-ORG Technology I-ORG MEXT O a O Grant-in-Aid O for O Scientific O Basic O Research O A) O No. O 20H00336 B-AWARD the O MEXT B-ORG ARIM I-ORG Japan I-ORG Advanced I-ORG Research I-ORG Infrastructure I-ORG for I-ORG Materials I-ORG and I-ORG Nanotechnology I-ORG in I-ORG Japan I-ORG of I-ORG Waseda I-ORG University O a O Grant-in-Aid O for O Early-Career O Scientists O No. O 22K15152 B-AWARD AMED B-ORG under O Grant O Number O JP22gm1610004 B-AWARD and O JST B-ORG ACT-X I-ORG Grant O Number O JPMJAX21KA B-AWARD Japan O These O are O Project O funded O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC0806900 O NSFC B-ORG 71841018 O and O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation O grant O number O 2019M650753 B-AWARD The O first O two O are O professor O Lei’s O second O author O founding O The O third O project O is O Doc O Meng’s O funding O This O research O was O funded O by O Anhui B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation O grant O number O 2008085MF182 B-AWARD Anhui B-ORG Provincial I-ORG DOHURD I-ORG Science I-ORG Foundation O grant O number O 2022-YF077 B-AWARD University B-ORG Synergy I-ORG Innovation I-ORG Program I-ORG of I-ORG Anhui I-ORG Province O grant O number O GXXT-2021-028 B-AWARD Program B-ORG of I-ORG Natural I-ORG Science I-ORG Research I-ORG Project I-ORG of I-ORG Anhui I-ORG Province I-ORG of I-ORG China O grant O number O KJ2021JD16 B-AWARD KJ2021A0622 B-AWARD This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 21806186 O 82073135 B-AWARD 82072374 B-AWARD 82002239 B-AWARD 81972776 B-AWARD 818030025 B-AWARD 81772928 B-AWARD and O 81772901 B-AWARD the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG 2019RS1005 O 2020JJ4766 B-AWARD and O 2020JJ4125 B-AWARD Fundamental O Research O Funds O for O Central B-ORG Universities I-ORG of I-ORG the I-ORG Central I-ORG South I-ORG University I-ORG 1053320190609 O CSU B-ORG Innovation-Driven I-ORG funding O 20180026040002 O 2021zzts0318 B-AWARD The O project O was O funded O by: O The O Oxford O Foundation O for O Theoretical O Neuroscience O and O Artificial O Intelligence O J.B.I O was O supported O by O the O Economic B-ORG and I-ORG Social I-ORG Research I-ORG Council I-ORG ESRC O grant O no. O ES/J500112/1 B-AWARD and O the O Engineering B-ORG and I-ORG Physical I-ORG Science I-ORG Research I-ORG Council I-ORG EPSRC O grant O no. O EP/N509711/1 B-AWARD N.A O was O supported O by O the O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG BBSRC O grant O no. O BB/J014427/1 B-AWARD J.M.G O and O M.J.B O were O supported O by O the O Medical B-ORG Research I-ORG Council I-ORG MRC O grant O no. O MR/K005480/1 B-AWARD and O a O Wellcome B-ORG Trust I-ORG Strategic I-ORG Award I-ORG grant O no. O WT101092MA B-AWARD This O research O was O funded O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82171898 O The O Doctor O Launch O Fund O of O National O Natural O Science O Foundation O of O Guangdong O Provincial O People’s O Hospital O 8210111541 O High-level B-ORG Hospital I-ORG Construction I-ORG Project I-ORG DFJH202109 O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangzhou I-ORG City I-ORG 202002030236 O Beijing B-ORG Medical I-ORG Award I-ORG Foundation I-ORG YXJL-2020-0941-0758 O and O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG 2022A1515012277 O Funding O sources O were O not O involved O in O the O study O design O data O collection O analysis O and O interpretation O writing O of O the O report O or O decision O to O submit O the O article O for O publication O The O present O study O was O funded O by O the O National B-ORG key I-ORG research I-ORG and I-ORG development I-ORG program I-ORG of I-ORG China I-ORG during I-ORG the I-ORG “14th I-ORG Five-Year I-ORG Plan I-ORG 2022YFD1700103 O The B-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Projects I-ORG of I-ORG Hunan I-ORG Province I-ORG 2020SK2033 O The B-ORG Science I-ORG and I-ORG Technology I-ORG development I-ORG program I-ORG guided I-ORG by I-ORG the I-ORG central I-ORG government I-ORG of I-ORG Hunan I-ORG Province I-ORG 2022ZYC04 O This O project O was O funded O by O Région B-ORG Auvergne-Rhône-Alpes I-ORG Pack O Ambition O project O NEW_MEG B-AWARD This O project O was O partly O funded O by O France O Life O Imaging O WP2 O O 4) O grant O “Infrastructure O d’avenir I-ORG en I-ORG Biologie I-ORG Santé” O ANR-11-INBS-0006 B-AWARD TG O is O supported O by O the O Labex B-ORG Cortex I-ORG ANR-11-LABX-0042 O This O research O was O financially O supported O by O the O Key B-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG Science I-ORG I-ORG Technology I-ORG Plan I-ORG No.2015B020233018 O the B-ORG Foundation I-ORG of I-ORG China I-ORG No.61471228 O and O The B-ORG Research I-ORG Start-up I-ORG Fund I-ORG Subsidized I-ORG Project I-ORG of I-ORG Shantou I-ORG University O China O Grant O No: O NTF17016 B-AWARD This O work O was O funded O by O the O Science B-ORG and I-ORG Technology I-ORG Fund I-ORG Planning I-ORG Projects I-ORG of O Qingdao O City O 21-1-4-ny-7-nsh O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR202103020217 O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG 2021LZGC001 O and O the O Taishan B-ORG Scholar I-ORG Construction I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ts20190946 O of O China O This O work O was O sponsored O by O the B-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Cotton I-ORG Biology I-ORG Open I-ORG Fund I-ORG Grant O No. O CB2016B01 B-AWARD the B-ORG “Seven I-ORG Crop I-ORG Breeding” I-ORG National I-ORG Major I-ORG Project I-ORG Grant O 2016YFD0101006 B-AWARD and O the B-ORG Genetically I-ORG Modified I-ORG Organism I-ORG Breeding I-ORG Major I-ORG Project I-ORG Grant O no. O 2014ZX08005-002 B-AWARD the B-ORG Program I-ORG of I-ORG National I-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O no. O 31071751 B-AWARD YH O received O the O fundings O The O funders O had O no O role O in O study O design O This O study O was O supported O financially O by O Guangzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG key I-ORG projects I-ORG No. O 201604020100 B-AWARD Guangdong B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG No. O 2017A020211017 B-AWARD and O Supporting B-ORG Foundation I-ORG of I-ORG Sun I-ORG Yat-sen I-ORG University I-ORG No. O 17ykjc17 B-AWARD The O corresponding O author O had O full O access O to O all O data O in O the O study O and O had O final O responsibility O for O the O decision O to O submit O for O publication O The O funding O bodies O of O this O study O had O no O role O in O the O study O design O collection O analysis O and O interpretation O of O data O or O writing O of O the O manuscript O Research O reported O in O this O publication O was O partially O supported O by O grants O from O the O National B-ORG Institute I-ORG of I-ORG Diabetes I-ORG and I-ORG Digestive I-ORG and I-ORG Kidney I-ORG Diseases I-ORG awarded O to O Dr. O Poston O R01DK064284 B-AWARD and O DK064284-S O an O Institutional O Development O Award O IDeA O Center O of O Biomedical O Research O Excellence O award O from O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG of O the O National O Institutes O of O Health O awarded O to O Dr. O Patterson O P20GM113125 B-AWARD and O the O University B-ORG of I-ORG Delaware I-ORG Research I-ORG Fund I-ORG awarded O to O Dr. O Patterson O 16A01366 B-AWARD The O funders O played O no O role O in O the O design O of O the O study O and O data O collection O analysis O interpretation O of O data O and O in O the O writing O of O this O manuscript O This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG China I-ORG grant O number O 2021J01831 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 32001713 B-AWARD 22038012 B-AWARD the O Research B-ORG Foundation I-ORG of I-ORG Jimei I-ORG University I-ORG grant O number O ZQ2020006 B-AWARD ZR2020004 B-AWARD and O the O Xiamen B-ORG Ocean I-ORG and I-ORG Fishery I-ORG Development I-ORG Special I-ORG Fund I-ORG project I-ORG 21CZP005HJ07 O This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81700829 O and O the O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O LY19H120006 O and O Medical B-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Provincial I-ORG Health I-ORG Commission I-ORG No. O 2018KY924 O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG LY20H120009 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31751003 O the O Health B-ORG Commission I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2022KY168 O and O the O Beijing B-ORG Bethune I-ORG Charitable I-ORG Foundation I-ORG BJ-GY2021013J O This O work O is O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2018YFA0703700 B-AWARD the O Shanghai B-ORG Municipal I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O No. O 20ZR1403200 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 61774040 B-AWARD 61774042 B-AWARD the O National B-ORG Young I-ORG 1000 I-ORG Talent I-ORG Plan I-ORG of I-ORG China O “First-Class O Construction” O project O of O Fudan O University O No. O XM03170477 B-AWARD and O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG ASIC I-ORG I-ORG System I-ORG Fudan I-ORG University I-ORG No. O 2018MS001 B-AWARD This O work O was O supported O by O grants O from O the O National O Natural B-ORG Science I-ORG Foundation I-ORG NSFC I-ORG of I-ORG China I-ORG U1705233 O 32272155 B-AWARD 32072103 B-AWARD 31701463 B-AWARD and O 31601337 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG of I-ORG China I-ORG 2021N5007 O and O 2017N0006 B-AWARD and O the O Special B-ORG Fund I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG of I-ORG Fujian I-ORG Agriculture I-ORG and I-ORG Forestry I-ORG University I-ORG KFb22010XA O and O KFb22011XA B-AWARD We O gratefully O acknowledge O funding O for O materials O statistics O and O travel O expenses O to O the O Foundation O for O Pathobiochemistry O and O Molecular O Diagnostics O German O Society O of O Clinical O Chemistry O and O Laboratory O Medicine O Germany O The O work O in O University O of O Valencia O was O financed O byCICYT-FEDER(AGL2008−02591-C02-01 O andMINECO-FEDER(AGL2012−39503-C02-01 O The O work O at O Universitario O Miguel O Servet O Zaragoza O Spain O was O funded O byFondo O de I-ORG Investigación I-ORG Sanitaria(FIS O PI15/01983 B-AWARD Work O in O Swansea O was O supported O by O theUK O Biotechnology I-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council(BBSRC O grant O numbers O BB/I001735/1 B-AWARD and O BB/L001942/1 B-AWARD Singapore B-ORG Ministry I-ORG of I-ORG Health I-ORG Open I-ORG Fund-Large I-ORG Collaborative I-ORG Grant O MOH-OFLCG18May-0002 O Lee O Kong O Chian O School O of O Medicine O Start O Up O Grant O from O Singapore O Ministry O of O Education O #002642-00001 O and O National B-ORG Medical I-ORG Research I-ORG Council-Translational I-ORG and I-ORG Clinical I-ORG Research I-ORG NMRC/TCR/013-NNI/2014 O awarded O to O K.L.L O and O Khoo B-ORG Pilot I-ORG Award I-ORG Duke/Duke-NUS/RECA(Pilot)/2016/0023 O awarded O to O K.L.L O and O T.P.Y O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 81202419 B-AWARD and O 81773866 B-AWARD the O Scientific O Research O Start-up O Funds O of O Jianghan B-ORG University I-ORG grant O numbers O 08190001 B-AWARD 2021yb138 B-AWARD and O 2019037 B-AWARD the O Scientific O Research O Project O Funding O of O Jianghan O University O grant O numbers O 08190006 B-AWARD 06210035 B-AWARD and O by O the O Wuhan B-ORG Municipal I-ORG Education I-ORG Bureau I-ORG CXY202204 O This O study O was O supported O by O grants O from O the O National B-ORG Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute I-ORG R01HL104608 O R01HL117004 B-AWARD R01HL128439 B-AWARD R01HL135156 B-AWARD X01HL134589 B-AWARD National B-ORG Institute I-ORG of I-ORG Environmental I-ORG Health I-ORG Sciences I-ORG R01ES015794 O R21ES24844 B-AWARD National B-ORG Institute I-ORG on I-ORG Minority I-ORG Health I-ORG and I-ORG Health I-ORG Disparities I-ORG P60MD006902 O R01MD010443 B-AWARD RL5GM118984 B-AWARD National B-ORG Institute I-ORG of I-ORG Neurological I-ORG Disorders I-ORG and I-ORG Stroke I-ORG R01NS051630 O P01NS097206 B-AWARD U54NS091859 B-AWARD National B-ORG Science I-ORG Foundation I-ORG ACI O 1443054 O IIS B-AWARD 1350885 O Tobacco-Related B-ORG Disease I-ORG Research I-ORG Program I-ORG 24RT-0025 O The O Genes-Environments O and O Admixture O in O Latino O Americans O GALA O II) O Study O the O Study O of O African O Americans O Asthma O Genes O and O Environments O SAGE O Study O and O E.G.B O are O supported O by O the O Sandler O Family O Foundation O the O American O Asthma O Foundation O the O RWJF O Amos O Medical O Faculty O Development O Program O and O the O Harry O Wm. O and O Diana O V. O Hind O Distinguished O Professor O in O Pharmaceutical O Sciences O II. O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 62272485 B-AWARD and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Xinjiang I-ORG Uygur I-ORG Autonomous I-ORG Region I-ORG Grant O No.2020DO1A131 O under O the O cooperation O this O work O was O successfully O established O and O conducted O This O work O was O mainly O supported O by O the O project O sponsored O by O the O Undergraduate B-ORG Training I-ORG Programs I-ORG for I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG of I-ORG Yangtze I-ORG University I-ORG under O Grant O Yz2021040 B-AWARD and O Teaching B-ORG Research I-ORG Fund I-ORG of I-ORG Yangtze I-ORG University I-ORG Grant O No. O JY2020101 B-AWARD The O project O enabled O us O to O purchase O and O establish O a O smart O retail O container O and O conduct O the O experiments O in O this O article O to O complete O the O recognition O of O smart O retail O goods O under O occlusion O This O work O was O supported O in O part O by O Grant O 2017ZX09304026 B-AWARD from O the B-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG for I-ORG Significant I-ORG New I-ORG Drugs I-ORG Creation O Grant O 81871107 B-AWARD and O 81870048 B-AWARD from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O Grant O BJ-2018-137 B-AWARD from O the B-ORG Beijing I-ORG Hospital I-ORG Nova I-ORG Project I-ORG This O work O was O supported O by O Proyecto B-ORG Interdisciplina I-ORG UC I-ORG No O 10/2013 B-AWARD Fondecyt B-ORG Postdoctorado I-ORG 3160525 O and O Fondecyt B-ORG de I-ORG Iniciacion I-ORG 11130518 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O manuscript O is O based O upon O work O supported O by O the O Natural O Resources O Conservation O Service O U.S B-ORG Department I-ORG of I-ORG Agriculture O under O No. O 69-3A75-16-013 B-AWARD Additional O funding O was O provided O by O the O Agricultural B-ORG Research I-ORG Service O U.S O Department O of O Agriculture O under O Agreement O No. O 58-3070-5-007 B-AWARD and O by O the O U.S B-ORG Geological I-ORG Survey I-ORG 104 B-AWARD b) I-AWARD program O administered O through O the O Oklahoma O Water O Resources O Center O This O work O was O supported O by O the O National B-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG of I-ORG China I-ORG U1304813 O the B-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Henan I-ORG Province I-ORG of I-ORG China I-ORG 17A310032 O Young B-ORG Teacher I-ORG Special I-ORG Fund I-ORG of I-ORG Zhengzhou I-ORG University I-ORG 1421328055 O Foundation B-ORG and I-ORG Frontier I-ORG Technology I-ORG Research I-ORG Project I-ORG in I-ORG Henan I-ORG Province I-ORG 142300410325 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20171231 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. I-AWARD 31472223 O grants O from O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG No. O 2015BAD12B05 O China B-ORG Agricultural I-ORG Research I-ORG System I-ORG CARS-43-8 O and O Special B-ORG Fund I-ORG for I-ORG Key I-ORG Laboratory I-ORG of I-ORG Animal I-ORG Diseases I-ORG and I-ORG Human I-ORG Health I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2016JPT0004 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O is O supported O by O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Grant O No. O XDB31000000 B-AWARD the O Joint B-ORG Fund I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China-Yunnan I-ORG Province I-ORG Grant O No. O U1902203 B-AWARD Southeast B-ORG Asia I-ORG Biodiversity I-ORG Research I-ORG Institute I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Grant O No. O 151C53KYSB20200019 B-AWARD and O the O CAS B-ORG 135 I-ORG program I-ORG Grant O No. O 2017XTBG-T01 B-AWARD Arshad O Ali O is O supported O by O Hebei B-ORG University I-ORG Grant O No. O 521100221033 B-AWARD This O research O was O funded O by O the O Open B-ORG Project I-ORG of I-ORG Key I-ORG Laboratory I-ORG in I-ORG Xinjiang I-ORG Uygur I-ORG Autonomous I-ORG Region I-ORG of I-ORG China I-ORG 2022D04082 O the O Independent B-ORG Research I-ORG Project I-ORG of I-ORG the I-ORG Xinjiang I-ORG Institute I-ORG of I-ORG Ecology I-ORG and I-ORG Geography I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG E2500201 O Natural B-ORG Science I-ORG Foundation I-ORG Research I-ORG Program I-ORG of I-ORG Shaanxi I-ORG 2021JQ-684 O Shaanxi B-ORG Province I-ORG Key I-ORG R&D I-ORG Program I-ORG Project I-ORG 2023-YBSF-475 O Xi’an B-ORG Polytechnic I-ORG University I-ORG transverse I-ORG research I-ORG project I-ORG 2023KJ-020 O Xi’an B-ORG Polytechnic I-ORG University I-ORG Ph.D I-ORG Research I-ORG Startup I-ORG Fund I-ORG BS201921 O and O Domestic B-ORG Visiting I-ORG Scholar I-ORG Program I-ORG of I-ORG Xi’an I-ORG Polytechnic I-ORG University I-ORG DP20200110 O This O work O was O supported O by O The O Natural B-ORG Youth I-ORG Science I-ORG Foundation I-ORG of I-ORG Shanxi I-ORG province I-ORG Grant O No. O 202103021223005 B-AWARD the O fund O for O Shanxi O “1331” O project O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Plan I-ORG for I-ORG colleges I-ORG and I-ORG universities I-ORG in I-ORG Shanxi I-ORG Province I-ORG 2022L575 O The O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG in I-ORG Higher I-ORG School I-ORG in I-ORG Shanxi I-ORG J2020383 O Teaching B-ORG Reform I-ORG and I-ORG Innovation I-ORG Project I-ORG of I-ORG Education I-ORG Department I-ORG of I-ORG Shanxi I-ORG Province I-ORG J20221195 O and O Teaching B-ORG Reform I-ORG and I-ORG Innovation I-ORG Project I-ORG of I-ORG Taiyuan I-ORG University I-ORG jg202205 O The O study O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 81670339 B-AWARD and O 81970311 B-AWARD the O Beijing B-ORG Lisheng I-ORG Cardiovascular I-ORG Pilot I-ORG Foundation I-ORG Grant O No. O LHJJ201612127 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG Grant O No. O 2014B070706010 B-AWARD The O funding O bodies O played O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2018YFD B-AWARD 0201000 O the O Heilongjiang B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O C2016051 B-AWARD and O the O Heilongjiang B-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG Foundation I-ORG No. O 2019CGJL002 B-AWARD The O funding O bodies O played O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2018YFD0900804 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31872569 B-AWARD and O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG No. O XDB42000000 B-AWARD Field O experiments O were O approved O by O National O Natural O Science O Foundation O of O China O Project O number O 31401955 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O authors O are O grateful O for O the O financial O support O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0201600 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41601267 O the O Project B-ORG of I-ORG China I-ORG Ministry I-ORG of I-ORG Agriculture I-ORG 2110402 O and O Beijing B-ORG Agriculture I-ORG Innovation I-ORG Consortium I-ORG BAIC01-2019 O the O over O the O years O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the B-ORG Key I-ORG Program I-ORG of I-ORG Joint I-ORG Funds I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 21242015 B-AWARD the B-ORG Major I-ORG Scientific I-ORG and I-ORG Technological I-ORG Project I-ORG in I-ORG Anhui I-ORG Province I-ORG No. O 17030701029 B-AWARD and O the B-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG Department I-ORG of I-ORG Education I-ORG of I-ORG Anhui I-ORG Province I-ORG No. O GXXT-2019-032 B-AWARD Ethel O Moore O Alzheimer’s O Program O National B-ORG Institutes I-ORG of I-ORG Health O Grant/Award O Number O T32 B-AWARD NS082168 O National B-ORG Institute I-ORG on I-ORG Aging O Grant/Award O Number O R01 B-AWARD AG054370 O R21 B-AWARD AG057200 O T32 B-AWARD AG020499 O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health O Grant/Award O Number O R03 B-AWARD MH109336 O National B-ORG Institute I-ORG of I-ORG Child I-ORG Health I-ORG and I-ORG Human I-ORG Development O Grant/Award O Number O R01 B-AWARD HD091658 O National B-ORG Institute I-ORG of I-ORG Nursing I-ORG Research O Grant/Award O Number O R01 B-AWARD NR014810 O State O of O Florida O Education O National B-ORG Institute I-ORG of I-ORG Neurological I-ORG Disorders I-ORG and I-ORG Stroke O Grant/Award O Number O R01 B-AWARD NS082386 O R01 B-AWARD NS096008 O UH3 B-AWARD NS095553 O This O research O was O funded O by O Jiangsu B-ORG Post-Doctoral I-ORG Fund O grant O number O 1107030170 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 81671807 B-AWARD and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities O grand O number O 2242018K3DN05 B-AWARD and O 2242017K40236 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 71704045 B-AWARD 71804141 B-AWARD and O 71502047 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities O grant O number O JZ2017HGBZ0924 B-AWARD and O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation O grant O number O 2017M620459 B-AWARD and O 2018T111080 B-AWARD This O work O was O supported O by O Shahroud B-ORG University I-ORG of I-ORG Medical I-ORG Sciences I-ORG Grant O Number O 99135 B-AWARD 140068 O Vice-chancellery B-ORG for I-ORG research I-ORG and I-ORG technology I-ORG at I-ORG Iranian I-ORG Ministry I-ORG of I-ORG Health I-ORG and I-ORG Medical I-ORG Education I-ORG Grant O Number O 2302 B-AWARD and O World B-ORG Health I-ORG Organization I-ORG WHO O References O 2021/1169483-0 B-AWARD and O 2022/1217943-1 B-AWARD This O research O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG LC2015006 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31101845 O and O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Veterinary I-ORG Biotechnology I-ORG Foundation I-ORG SKLVBF201611 O This O work O was O financially O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31700708 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O BK20170181 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O JUSRP11960 B-AWARD This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81500490 O Application B-ORG Research I-ORG of I-ORG Capital I-ORG Clinical I-ORG Character I-ORG Z151100004015215 O and O Annual B-ORG Project I-ORG of I-ORG Air I-ORG Force I-ORG General I-ORG Hospital I-ORG KZ2015026 O and O KZ2016021 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O nos O 22075185 B-AWARD 51773118 B-AWARD 51902073 B-AWARD and O 52272291 B-AWARD the B-ORG Guangdong I-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG grant O no. O 2019A1515111040 B-AWARD and O the B-ORG funding I-ORG program I-ORG of I-ORG Foshan I-ORG supporting I-ORG policies I-ORG for I-ORG promoting I-ORG the I-ORG service I-ORG industry I-ORG of I-ORG scientific I-ORG achievements I-ORG in I-ORG universities I-ORG grant O no. O 2019XCC08 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 41907037 B-AWARD 41977125 B-AWARD the O Research B-ORG Foundation I-ORG of I-ORG Education I-ORG Bureau I-ORG of I-ORG Hunan I-ORG Province O China O grant O number O 22A0608 B-AWARD and O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG Hunan I-ORG Province I-ORG grant O number O 2021NK2030 B-AWARD This O work O is O financed O by O national O funds O through O FCT—Foundation O for I-ORG Science I-ORG and I-ORG Technology O I.P O within O the O scope O of O the O projects O LA/P/0069/2020 B-AWARD granted O to O the O Associate O Laboratory O ARNET O UIDB/04292/2020—granted B-AWARD to O MARE—Marine O and O Environmental O Sciences O Centre O and O UIDP/50017/2020+UIDB/50017/2020 B-AWARD by O FCT/MTCES O granted O to O CESAM—Centre O for O Environmental O and O Marine O Studies O This O research O was O co-financed O by O the O project O AlgaMar4antivirus—Marine O MacroalgaE O in O the O prevention O and O treatment O of O ANTIviral O diseases O Coronavirus O SARS-CoV-2 O FA_07_2018_009 O funded O by O the O Blue B-ORG Fund I-ORG under O Public O Notice O No. O 7 O 2018—Scientific O Research O and O Marine O Technology O Silvia O Lomartire O thanks O the O Foundation O for O Science O and O Technology O FCT O for O the O financial O support O granted O through O the O doctoral O grant O 2021.05005.BD B-AWARD Ana O M. O M. O Gonçalves O acknowledges O the O University B-ORG of I-ORG Coimbra I-ORG for O the O contract O IT057-18-7253 B-AWARD National B-ORG Research I-ORG Foundation I-ORG NRF I-ORG of I-ORG Korea O Genomics O Program O 2016M3C9A3945893 O Basic B-ORG Science I-ORG Research I-ORG Program I-ORG NRF O 2017R1E1A1A03070107 O NRF-2018R1A5A1024340 O Bio-Synergy B-ORG Research I-ORG Project I-ORG NRF-2017M3A9C4065956 O Funding O for O open O access O charge O NRF O NRF-2016M3C9A3945893 O This O work O was O partly O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81872459 O 81803050 O the B-ORG Commission I-ORG Young I-ORG and I-ORG Middle-aged I-ORG Talents I-ORG Training I-ORG Project I-ORG of I-ORG Fujian I-ORG Health I-ORG Commission I-ORG No. O 2019-ZQNB-25 B-AWARD and O the B-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Projects I-ORG of I-ORG Xiamen I-ORG Science I-ORG I-ORG Technology I-ORG Bureau I-ORG No. O 3502Z20174070 B-AWARD This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 31470535 B-AWARD 31472210 B-AWARD Natural B-ORG Science I-ORG Basic I-ORG Research I-ORG Plan I-ORG in I-ORG Shaanxi I-ORG Province I-ORG of I-ORG China I-ORG grant O number O 2014JM3060 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG grant O number O 2014M562456 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 8002-7215616001 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O NIGMS B-ORG grant O GM50936 B-AWARD and O NCATS B-ORG grant O 1UL1TR002389-01 B-AWARD to O DKB O DFR O was O partly O supported O by O the O NIH B-ORG Genetics I-ORG I-ORG Regulation I-ORG Training I-ORG Grant I-ORG T32 O GM07197 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81572608 B-AWARD 81172422 B-AWARD Wuhan B-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG No. O 2017060201010170 B-AWARD and O the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2015AA020301 B-AWARD This O study O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81573898 B-AWARD No. O 81473640 B-AWARD and O No. O 81273742 B-AWARD the O Scientific B-ORG Research I-ORG Key I-ORG Program I-ORG of I-ORG Beijing I-ORG Municipal I-ORG Commission I-ORG of I-ORG Education I-ORG KZ201310025023 O and O the O Program B-ORG of I-ORG Changcheng I-ORG Scholars I-ORG for I-ORG the I-ORG Importation I-ORG and I-ORG Development I-ORG of I-ORG High-Caliber I-ORG Talents I-ORG Project I-ORG of I-ORG Beijing I-ORG Municipal I-ORG Institutions I-ORG CIT&TCD20140329 O This O work O was O supported O by O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Science I-ORG XDA20100102 O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2014CB138706 O Changjiang B-ORG Scholars I-ORG and I-ORG Innovative I-ORG Research I-ORG Team I-ORG in I-ORG University I-ORG IRT17R50 O and O The B-ORG 111 I-ORG project I-ORG B12002 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 61401363 B-AWARD K.Z O Natural B-ORG Sciences I-ORG and I-ORG Engineering I-ORG Research I-ORG Council I-ORG of I-ORG Canada I-ORG NSERC I-ORG Collaborative I-ORG Research I-ORG and I-ORG Development I-ORG Grants I-ORG Grant O No. O CRDPJ B-AWARD 446638-12 O K.H O Science B-ORG and I-ORG Technology I-ORG on I-ORG Avionics I-ORG Integration I-ORG Laboratory I-ORG and I-ORG Aeronautical I-ORG Science I-ORG Foundation I-ORG Grant O No. O 20155153034 B-AWARD K.Z O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No. O 3102016AXXX005 B-AWARD 3102015BJIIJGZ009 O K.Z O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O BEATS O Study O was O supported O by O the O Health B-ORG Research I-ORG Council I-ORG of I-ORG New I-ORG Zealand I-ORG Emerging O Researcher O First O Grant O 14/565 O the O National B-ORG Heart I-ORG Foundation I-ORG of I-ORG New I-ORG Zealand I-ORG 1602 O and I-AWARD 1615 O a O Lottery B-ORG Health I-ORG Research I-ORG Grant O Applic O 341129 O a O University B-ORG of I-ORG Otago I-ORG Research O Grant O UORG O 2014 O the O Dunedin O City O Council O and O internal O grants O from O the O School O of O Physical O Education O Sport O and O Exercise O Sciences O University O of O Otago O This O work O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0300602 O 2016YFD0300209 I-AWARD to O WY O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG 31571615 O to O WY O and O Program B-ORG on I-ORG Industrial I-ORG Technology I-ORG System I-ORG of I-ORG National I-ORG Soybean I-ORG CARS-04-PS19 O to O WY O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O NVK O a O CPRIT O scholar O in O Cancer O Research O thanks O the O Cancer B-ORG Prevention I-ORG and I-ORG Research I-ORG Institute I-ORG of I-ORG Texas I-ORG CPRIT O for O their O generous O support O CPRIT O grant O RR150044 B-AWARD This O work O was O also O supported O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIGMS O R35GM129294 B-AWARD to O NK) O and O the O Welch B-ORG Foundation I-ORG C-1930 O to O NVK O This O work O was O supported O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81700955 B-AWARD Nature B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG of I-ORG China I-ORG grant O number O 304220100140 B-AWARD and O Independent B-ORG Research I-ORG Projects I-ORG of I-ORG Wuhan I-ORG University I-ORG of I-ORG China I-ORG grant O number O 304-2042016KF1004 B-AWARD This O research O was O funded O by O the O Comunidad B-ORG de I-ORG Madrid I-ORG S2018/EMT-4459 O RETOPROSOST-2-CM B-AWARD Program O the O AEI/FEDER/UE B-ORG BIO2015-73697-JIN O FungiQuorum O the O MCIN/AEI B-ORG PID2020-114210RB-I00 O MICODE O and O the O MCIN/AEI/“NextGenerationEU”/PRTR B-ORG TED2021-130096B-I00 O DEMO O This O study O was O supported O by O grants O from O the O General O Program O of O National O Natural O Scientific O Foundation O of O China O No. O 81970923 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFC1000505 B-AWARD Key B-ORG Research I-ORG Program I-ORG of I-ORG Provincial I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG No. O 2017ACA181 B-AWARD and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG No. O 2017CFB212 B-AWARD This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFA0500902 B-AWARD to O Mingxi O Liu O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31771651 O and O 31571538 B-AWARD to O Zuomin O Zhou O 31571536 B-AWARD 31771654 B-AWARD and O 31530047 B-AWARD to O Mingxi O Liu O the O Natural B-ORG Science I-ORG Fund I-ORG for I-ORG Colleges I-ORG and I-ORG Universities I-ORG in I-ORG Jiangsu I-ORG Province I-ORG 16KJA310003 B-AWARD to O Mingxi O Liu O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grants O No. O BK20190081 B-AWARD to O Mingxi O Liu O and O the O Qing O Lan O Project O to O Mingxi O Liu O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O Grants O from O Jiangsu B-ORG Provincial I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG to O Ailiang O Zhang O Z201614 O Changzhou B-ORG High-Level I-ORG Medical I-ORG Talents I-ORG Training I-ORG Project I-ORG to O Jinbo O Liu O 2016ZCLJ005 O and O the O Science B-ORG and I-ORG Technology I-ORG Bureau I-ORG of I-ORG Changzhou I-ORG to O Ailiang O Zhang O No. O CJ20130029 B-AWARD This O research O was O supported O by O the O Zhejiang B-ORG provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Y18C040006 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31370042 O the O College O students’ O Innovation B-ORG and I-ORG Entrepreneurship I-ORG Project I-ORG in I-ORG China I-ORG No. O 201810345043 B-AWARD the O College B-ORG students I-ORG in I-ORG Zhejiang I-ORG Normal I-ORG University I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Plan I-ORG 2018-317 O for O the O study O design O data O collection O and O analyses O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O No. O 81803466 B-AWARD the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Program I-ORG Grant O No. O 2017zx09101001 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG Grant O No. O 2018A030310095 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Foundation I-ORG Guangzhou I-ORG Grant O No. O 201707010103 B-AWARD This O work O was O financially O supported O by O the O project O “Program O for I-ORG the I-ORG conservation I-ORG of I-ORG wild I-ORG populations I-ORG of I-ORG Gossypium I-ORG hirsutum I-ORG in I-ORG Mexico” O DGAP003/WN003/18 B-AWARD Dirección O General O del O Sector O Primario O y O Recursos O Naturales O Renovables O DGSPRNR O that O belongs O to O the O SEMARNAT O and O CONABIO O and O the O project O UNAM-PAPIIT B-ORG No. O IN214719 B-AWARD Alejandra O Hernández-Terán O is O a O doctoral O student O from O Programa O de O Doctorado O en O Ciencias O Biomédicas O Universidad O Nacional O Autónoma O de O México O UNAM O and O was O supported O by O CONACYT B-ORG scholarship O no. O 66025 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O partially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32272742 O 32202508 B-AWARD the O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG LY20C150001 O and O the O National B-ORG College I-ORG Students I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Training I-ORG Program I-ORG 202210341024 O This O research O was O supported O by O Key-Area B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2018B030331001 O 2018B030338001 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant I-ORG 31930047 O 31700936 B-AWARD National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC1310503 O 2020YFC2008503 B-AWARD Scientific B-ORG and I-ORG Technological I-ORG Innovation I-ORG 2030 I-ORG Key I-ORG Project I-ORG 2022ZD0209800 O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Science I-ORG XDB32030103 O National B-ORG Special I-ORG Support I-ORG Grant I-ORG W02020453 O NSFC-Guangdong B-ORG Joint I-ORG Fund I-ORG U20A6005 O the O Guangdong B-ORG Provincial I-ORG Grant I-ORG 2017A030310496 O Shenzhen B-ORG Infrastructure I-ORG for I-ORG Brain I-ORG Analysis I-ORG and I-ORG Modeling I-ORG ZDKJ20190204002 O Shenzhen B-ORG Governmental I-ORG Basic I-ORG Research I-ORG Grants I-ORG JCYJ20160531174444711 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31600181 B-AWARD Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O LQ16C020003 B-AWARD and I-AWARD LY17B020012 O and O Zhejiang B-ORG Provincial I-ORG Major I-ORG Agriculture I-ORG Science I-ORG and I-ORG Technology I-ORG Special I-ORG Sub-project I-ORG Grant O No. O 2016C02050-10-3 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O United B-ORG Nations I-ORG Development I-ORG Programme I-ORG No. O CSP-2016-057 B-AWARD National B-ORG Commission I-ORG of I-ORG Natural I-ORG Protected I-ORG Areas I-ORG Mexico O No. O FN009 B-AWARD O No. O KN003 B-AWARD National B-ORG Forestry I-ORG Commission I-ORG Mexico O No. O 137252 B-AWARD Ministry B-ORG of I-ORG Environment I-ORG and I-ORG Natural I-ORG Resources I-ORG Mexico O No. O S0010-1108099 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Key I-ORG Clinical I-ORG Specialty I-ORG Discipline I-ORG Construction I-ORG Program I-ORG of I-ORG China I-ORG No. O 2012 B-AWARD 649 O Key B-ORG Projects I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG of I-ORG Fujian I-ORG Province I-ORG No. O 2014Y0025 B-AWARD and O Youth B-ORG scientific I-ORG research I-ORG subject I-ORG of I-ORG Fujian I-ORG provincial I-ORG health I-ORG and I-ORG family I-ORG planning I-ORG commission I-ORG No. O 2015-1-37 B-AWARD The O funding O body O had O no O role O in O the O study O design O data O collection O and O analysis O or O preparation O of O manuscript O This O work O was O supported O by O a O New O Investigator O Operating O Grant O from O Research B-ORG Manitoba I-ORG formerly O Manitoba O Health O Research O Council)—New O Investigator O Operating O grant O number O 796 B-AWARD the O Developmental B-ORG Origins I-ORG of I-ORG Chronic I-ORG Disease I-ORG in I-ORG Children I-ORG Network I-ORG DEVOTION O grant O number O PHP3 B-AWARD and O in O part O by O the O Lawson B-ORG Foundation I-ORG grant O number O GRT2015-6 B-AWARD This O work O was O supported O by O grants O from O the O Ministry B-ORG of I-ORG National I-ORG Defense-Medical I-ORG Affairs I-ORG Bureau I-ORG MND-MAB-111-144 O to O G.-S.C O the O Teh-Tzer O Study O Group O for O Human B-ORG Medical I-ORG Research I-ORG Foundation I-ORG A1111035 O to O S.-M.H O and O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG MOST–111-2320-B-016-012 O to O S.-M.H O Taiwan O This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG 2017YFA0103803 O 2016YFA0500903 B-AWARD 2016YFA0503300 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31571538 O 31771651 B-AWARD 31890784 B-AWARD and O 31701300 B-AWARD and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grants O No. O BK20190081 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51708095 O 51578117 B-AWARD 51722803 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2412017QD027 O 2412018ZD013 B-AWARD 2412018ZD042 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Jilin I-ORG Province I-ORG 20180520168JH O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017M611302 O 2018T110241 B-AWARD for O their O financial O support O We O also O thank O Dr. O Yanhong O Xiao O and O Dr. O Nan O Lu, O Experiment O Center O of O School O of O Environment O Northeast O Normal O University O for O assistance O with O our O experimental O data O acquisition O This O work O was O funded O by O the O Guizhou B-ORG Province I-ORG high-level I-ORG talent I-ORG innovation I-ORG and I-ORG entrepreneurship I-ORG merit I-ORG funding I-ORG project I-ORG No. O 202104 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Project I-ORG 2020M683657XB O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 31900020 O the O Science B-ORG and I-ORG Technology I-ORG Foundation I-ORG of I-ORG Guizhou I-ORG Province I-ORG [2020]1Y058 O and O the O academic O emerging O project O of O the O Guizhou B-ORG Institute I-ORG of I-ORG Technology I-ORG GZLGXM-15 O Secretary B-ORG of I-ORG Science I-ORG Technology I-ORG and I-ORG Higher I-ORG Professional I-ORG and I-ORG Technological I-ORG Education I-ORG of I-ORG the I-ORG State I-ORG of I-ORG Pará I-ORG SECTET O 09/2021 B-AWARD Amazon B-ORG Foundation I-ORG for I-ORG Research I-ORG Support I-ORG FAPESPA)—#006/2020 O and O 060/2020 B-AWARD The B-ORG Coordination I-ORG for I-ORG the I-ORG Improvement I-ORG of I-ORG Higher I-ORG Education I-ORG Personnel I-ORG CAPES I-ORG National I-ORG Council I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Development I-ORG CNPQ)—#401235/2020-3 O The O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31871656 O the O National B-ORG Program I-ORG on I-ORG Key I-ORG Basic I-ORG Research I-ORG Project I-ORG 2015CB150205 O and O the O New B-ORG Century I-ORG Talents I-ORG Support I-ORG Program I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG NCET110172 O The O funding O bodies O were O not O involved O in O the O design O of O the O study O data O collection O interpretation O of O data O or O in O writing O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 62273360 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG Grant O No. O 2020JJ4382 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG Central I-ORG South I-ORG University I-ORG 2021zzts0180 O This O work O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD060040301 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 41601045 B-AWARD 31570632 B-AWARD 41571094 B-AWARD and O the O talents O introduction O program O in O Hebei B-ORG Agricultural I-ORG University I-ORG YJ201918 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Department B-ORG of I-ORG Veterans I-ORG Affairs I-ORG the I-ORG Veterans I-ORG Health I-ORG Administration I-ORG the I-ORG Office I-ORG of I-ORG Research I-ORG and I-ORG Development I-ORG Clinical I-ORG Sciences I-ORG R&D I-ORG CSRD I-ORG I01 I-ORG CX002015 B-AWARD Anat O Galor O Biomedical B-ORG Laboratory I-ORG R&D I-ORG BLRD I-ORG Service I-ORG I01 I-ORG BX004893 B-AWARD Anat O Galor O Rehabilitation B-ORG R&D I-ORG RRD I-ORG I21 I-ORG RX003883 B-AWARD Anat O Galor O the O Department B-ORG of I-ORG Defense I-ORG Gulf I-ORG War I-ORG Illness I-ORG Research I-ORG Program I-ORG GWIRP O W81XWH-20-1-0579 B-AWARD Anat O Galor O the O Department B-ORG of I-ORG Defense I-ORG Vision I-ORG Research I-ORG Program I-ORG VRP O W81XWH-20-1-0820 B-AWARD Anat O Galor O the O National B-ORG Eye I-ORG Institute I-ORG R01EY026174 B-AWARD Anat O Galor O and O R61EY032468 B-AWARD Anat O Galor O the O NIH B-ORG Center I-ORG Core I-ORG Grant O P30EY014801 B-AWARD institutional O and O Research B-ORG to I-ORG Prevent I-ORG Blindness I-ORG Unrestricted I-ORG Grant O GR004596 B-AWARD institutional O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 62275017 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG No. O 2022YFF0609500 B-AWARD SongShan B-ORG Laboratory(No O YYJC072022008 B-AWARD and O the O BIT B-ORG Research I-ORG and I-ORG Innovation I-ORG Promoting I-ORG Project I-ORG Grant O No. O 2022YCXY034 B-AWARD This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0501707 O the O National B-ORG Key I-ORG Technology I-ORG R&D I-ORG Program I-ORG 2015BAC01B03 O and O the O West B-ORG Young I-ORG Scholars I-ORG Project I-ORG of I-ORG The I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XAB2015A05 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O the O Earmarked B-ORG Fund I-ORG of I-ORG Anhui I-ORG Fishery I-ORG Research I-ORG System I-ORG No. O 2016-84 O Anhui B-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG Technology I-ORG Innovation I-ORG Team I-ORG No. O 2019YL026 O and O Chinese B-ORG agriculture I-ORG research I-ORG system I-ORG No. O CARS-48 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the B-ORG Youth I-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG 2015YNQ16 O to O WD, O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31501261 O to O WD, O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2015YL074 O to O WD O and O the B-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG of I-ORG Sweetpotato I-ORG CARS-11-B-11 O and O CARS-10-B-8 O to O LZ. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O National B-ORG Basic I-ORG Research I-ORG 973 I-ORG Program I-ORG of O China O 2012CB114204 O the O National B-ORG Transgenic I-ORG Project I-ORG 2013ZX08002003 B-AWARD the O Major B-ORG Program I-ORG of I-ORG the I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31430060 B-AWARD and O the O Shandong B-ORG Province I-ORG Postdoctoral I-ORG Innovation I-ORG Project I-ORG 201202016 B-AWARD This O study O was O supported O by O research O grants O from O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 201762014 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31772414 O and O Industrial B-ORG Development I-ORG Project I-ORG of I-ORG Qingdao I-ORG City I-ORG 17-3-3-64-nsh O to O Qi O Li. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O 863 B-ORG Program I-ORG No. O 2012AA02A515 B-AWARD No. O 2012AA021802 B-AWARD the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81773818 B-AWARD No. O 81273596 B-AWARD No. O 30900799 B-AWARD and O No. O 81671326 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG No. O 2017YFC0909303 B-AWARD No. O 2016YFC0905000 B-AWARD No. O 2016YFC0905002 B-AWARD No. O 2016YFC1200200 B-AWARD and O No. O 2016YFC0906400 B-AWARD the O 4th B-ORG Three-year I-ORG Action I-ORG Plan I-ORG for I-ORG Public I-ORG Health I-ORG of I-ORG Shanghai I-ORG No. O 15GWZK0101 B-AWARD the O Shanghai B-ORG Pujiang I-ORG Program I-ORG No. O 17PJD020 B-AWARD and O the O Shanghai B-ORG Key I-ORG Laboratory I-ORG of I-ORG Psychotic I-ORG Disorders I-ORG No. O 13dz2260500 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Funding O was O received O from O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFA0301204 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 11774202 O 51231007 O and O the O 111 B-ORG Project I-ORG B13029 O J.Z O D.R O R.D O and O S.G O were O partially O funded O by O UKRI B-ORG Biotechnology I-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council's I-ORG Designing I-ORG Future I-ORG Wheat I-ORG Cross-Institute I-ORG Strategic I-ORG Programme I-ORG BB/P016855/1 O to O Prof O Graham O Moore O BBS/E/J/000PR9781 B-AWARD to O S.G O and O BBS/E/T/000PR9785 B-AWARD to O J.Z O D.R O R.D O and O J.B O were O partially O supported O by O the O Core B-ORG Strategic I-ORG Programme I-ORG grant O BB/CSP17270/1 B-AWARD at O the O Earlham O Institute O D.R O J.B O and O A.B O were O also O partially O supported O by O Bayer/BASF's B-ORG G4T I-ORG grant O GP125JZ1J B-AWARD awarded O to O J.Z O This O study O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31660240 B-AWARD and O No. O 31660304 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFB0308401 B-AWARD Applied B-ORG Basic I-ORG Research I-ORG Foundation I-ORG of I-ORG Yunnan I-ORG Province I-ORG No. O 2016FD018 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 12171387 O M.S. O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M631134 O M.S O 2020T130095ZX B-AWARD M.S. O Young B-ORG Talent I-ORG Support I-ORG Program I-ORG of I-ORG Shaanxi I-ORG University I-ORG Association I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG 20210307 O M.S. O This O work O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O U180120050 B-AWARD 61702192 B-AWARD and O U1636218 B-AWARD Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG 201704020043 O Natural O Science O Foundation O of O Guangdong O Province O of O China O 2018A030310407 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2018ZD11 O The O experimental O research O at O Solvay O S.A O was O made O possible O thanks O to O financial O support O from O the O Brussels B-ORG Capital I-ORG region I-ORG by I-ORG the I-ORG INNOVIRIS I-ORG Explore I-ORG program O project O “P-SCOPE” O 2019-RDIR-48 O Part O of O the O modelling O work O leading O to O this O paper O has O been O funded O by O the O ICON B-ORG project I-ORG “ProPeL” I-ORG HBC.2019.0094 O which O fits O in O the O MacroModelMat O M3) O research O program O coordinated O by O Siemens O Siemens O Digital O Industries O Software O Belgium O and O funded O by O SIM O Strategic O Initiative O Materials O in O Flanders O and O VLAIO O Flemish O government O agency O Flanders O Innovation O O Entrepreneurship O R.D.B O Sevenois O acknowledges O the O financial O support O of O the O “Fonds O Wetenschappelijk I-ORG Onderzoek” O FWO O fellowship O 12R3221N B-AWARD The O financial O support O from O the O Special B-ORG Research I-ORG Fund I-ORG program I-ORG by I-ORG Ghent I-ORG University I-ORG “Bijzonder O Onderzoek O Fonds” O BOF.STG.2018.0030.01 B-AWARD is O also O gratefully O acknowledged O which O has O made O possible O to O generate O the O key O modeling O and O theoretical O foundations O to O accomplish O this O research O This O research O was O funded O by O Guangdong B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 2017A030313158 O Modern B-ORG Agricultural I-ORG Industrial I-ORG Technology I-ORG System I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2019KJ127 O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG of I-ORG China I-ORG 2019B1515210020 O and O Guangdong B-ORG Provincial I-ORG Promotion I-ORG Project I-ORG on I-ORG Preservation I-ORG and I-ORG Utilization I-ORG of I-ORG Local I-ORG Breed I-ORG of I-ORG Livestock I-ORG and I-ORG Poultry I-ORG No.2018-143 O This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81130026 B-AWARD 81672215 B-AWARD 81702182 B-AWARD and O 81874028 B-AWARD National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG Grant O No. O 2016YFC1000805 B-AWARD Postgraduate B-ORG research I-ORG and I-ORG innovation I-ORG project I-ORG of I-ORG Chongqing I-ORG Grant O No. O CYB17143 B-AWARD The B-ORG clinical I-ORG research I-ORG project I-ORG of I-ORG the I-ORG Second I-ORG Affiliated I-ORG Hospital I-ORG of I-ORG Army I-ORG Medical I-ORG University I-ORG Grant O No. O 2015YLC22 B-AWARD This O research O was O funded O by O the O Bundesministerium B-ORG für I-ORG Bildung I-ORG und I-ORG Forschung I-ORG BMBF I-ORG funded I-ORG ERA-NET I-ORG program I-ORG Psi-Alc I-ORG FKZ O 01EW1908 O the O BMBF-funded B-ORG SysMedSUDs I-ORG consortium I-ORG FKZ O 01ZX1909A O Deutsche B-ORG Forschungsgemeinschaft I-ORG DFG O German O Research O Foundation)—Project-ID O ME B-AWARD 5279/3-1 I-AWARD and O Project-ID O 402170461–RR B-AWARD 265 I-AWARD and O European B-ORG Union’s I-ORG Horizon I-ORG 2020 I-ORG program O 668863-SyBil-AA O This O study O was O funded O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. I-AWARD 81772154 O The B-ORG Major I-ORG Infectious I-ORG Diseases I-ORG Such I-ORG as I-ORG AIDS I-ORG and I-ORG Viral I-ORG Hepatitis I-ORG Prevention I-ORG and I-ORG Control I-ORG Technology I-ORG Major I-ORG Projects I-ORG Grant O No. I-AWARD 2018ZX10712001 O and O Non-profit B-ORG Central I-ORG Research I-ORG Institute I-ORG Fund I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG Grant O No. I-AWARD 2018RC310027 O This O work O was O funded O by O National O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O Grant O Number O 81772778 O to O J.J O Shandong O Province I-ORG Key I-ORG Research I-ORG I-ORG Development I-ORG Program O Grant O Number O 2017GSF18175 O to O J.J O and O Fundamental O Research I-ORG Funds I-ORG of I-ORG Qilu I-ORG Hospital I-ORG of I-ORG Shangdong I-ORG University O Grant O Number O 2082015QLMS44 O to O J.J O This O project O carried O out O with O the O support O of O the O Explore B-ORG and I-ORG Innovative I-ORG Projects I-ORG of I-ORG doctoral I-ORG students I-ORG in I-ORG Central I-ORG South I-ORG University I-ORG 2015zzts118 O the O National B-ORG Key I-ORG Clinical I-ORG Specialist I-ORG Construction I-ORG Projects I-ORG (2012)No O 650 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81370143,81170036 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31600952 O and O 31271272 B-AWARD the O Start-Up B-ORG Research I-ORG Funding I-ORG of I-ORG Jiangsu I-ORG University I-ORG for I-ORG Distinguished I-ORG Scholars I-ORG 4111330006 O and O the O Postgraduate B-ORG Research I-ORG Practice I-ORG Innovation I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG KYCX22_3608 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 61504048 B-AWARD 51672109 B-AWARD 21505050 B-AWARD 21707043 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG for I-ORG Excellent I-ORG Young I-ORG Scholars I-ORG ZR2016JL015 O ZR2017BEE005 B-AWARD and O Technological B-ORG Development I-ORG Program I-ORG in I-ORG Shandong I-ORG Province I-ORG Education I-ORG Department I-ORG Grant O No. O J15LJ06 B-AWARD This O work O was O supported O by O funding O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81872368 O 81641051 B-AWARD Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Commission I-ORG Key I-ORG Projects I-ORG of I-ORG Fundamental I-ORG Research I-ORG and I-ORG Program I-ORG for I-ORG Building I-ORG Shenzhen I-ORG City I-ORG State I-ORG Key I-ORG Laboratories I-ORG JCYJ20180508152130899 O GuoKeFaJi B-AWARD 2018]38 O ZDSYS20140509172959975 B-AWARD GJHZ20140416153844269 B-AWARD JCYJ20140418112611757 B-AWARD JCYJ20130402145002438 B-AWARD and O Shenzhen B-ORG Development I-ORG and I-ORG Reform I-ORG Commission I-ORG Subject I-ORG Construction I-ORG Project I-ORG 2017]1434 B-AWARD This O study O was O supported O by O the O Scientific B-ORG Research I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG grant O number O 201840336 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG grant O number O 17ZR1427100 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 81300771 B-AWARD 31871281 B-AWARD 81400397 B-AWARD The O Project B-ORG of I-ORG Key I-ORG Disciplines I-ORG of I-ORG Medicine I-ORG in I-ORG Yangpu I-ORG District I-ORG of I-ORG Shanghai I-ORG grant O number O YP19ZA01 B-AWARD and O the O Shanghai B-ORG Jiao I-ORG Tong I-ORG Univ I-ORG Liberal I-ORG Arts I-ORG and I-ORG Sciences I-ORG Cross-Disciplinary I-ORG Project I-ORG grant O number O YG2014QN13 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Special O Fund O for O Agro-scientific B-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG of I-ORG China I-ORG 201303047 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG 18ZR1450000 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41576167 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Chunbo O Chen O is O currently O receiving O a O grant O #2014001 O from O the O Guangdong B-ORG Province I-ORG Hospital I-ORG Association I-ORG Scientific I-ORG Research I-ORG Foundation I-ORG and O a O grant O #201343 O from O the O Guangdong B-ORG General I-ORG Hospital I-ORG Scientific I-ORG Research I-ORG Foundation O Bo O Lv O is O currently O receiving O a O grant O #2013B021800158 O from O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG China O Bei O Hu O is O currently O receiving O a O grant O #2014A020212236 O from O the O Science O and O Technology O Planning O Project O of O Guangdong O Province O China O a O grant O #20181003 O from O the O Administration B-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG of I-ORG Guangdong I-ORG Province I-ORG China O and O a O grant O from O Guangdong B-ORG Medical I-ORG Scientific I-ORG Research I-ORG Foundation I-ORG #A2018034 O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81170937 B-AWARD the B-ORG Project I-ORG for I-ORG Culturing I-ORG Leading I-ORG Talents I-ORG in I-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG of I-ORG Beijing I-ORG Z171100001117169 O and O the B-ORG Liaoning I-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2013023014 O to I-AWARD FW O We O thank O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U20A2001 O 42276114 B-AWARD 82104228 B-AWARD the O Key-Area B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2020B1111030005 O and O the O GDAS B-ORG Special I-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Grant O No. O 2021GDASYL–20210103057 B-AWARD for O the O generous O support O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31630011 B-AWARD Science B-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2013B021800042 B-AWARD and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2015A030313784 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32270760 O and O 81902844 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Project O No. O 2021CDJYGRH-004 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Chongqing I-ORG China I-ORG CSTB2022NSCQ-MSX0832 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG National I-ORG Key I-ORG R&D I-ORG Project O 2022YFF0710700 O This O study O has O received O funding O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81471652 O 81771824 O 11705112 O 81701681 B-AWARD 81227901 B-AWARD 61231004 B-AWARD 81501616 O 81671854 O and O 81771924 B-AWARD the B-ORG Precision I-ORG Medicine I-ORG Key I-ORG Innovation I-ORG Team I-ORG Project I-ORG YT1601 O the B-ORG Social I-ORG Development I-ORG Projects I-ORG of I-ORG Key I-ORG R&D I-ORG programme I-ORG in I-ORG Shanxi I-ORG Province I-ORG 201703D321016 O and B-ORG the I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Shanxi I-ORG Province I-ORG 201601D021162 O the O China O Postdoctoral O Science O Foundation O 2017M621108 O the O Natural O Science O Foundation O of O Shanxi O Province O 201601D021162 O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFA0205200 O 2017YFC1308700 O 2017YFC1308701 O and O 2017YFC1309100 B-AWARD the B-ORG Science I-ORG and I-ORG Technology I-ORG Service I-ORG Network I-ORG Initiative I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG KFJ-SW-STS-160 O Present O work O was O supported O by O Chinese B-ORG Society I-ORG of I-ORG Endocrinology I-ORG the I-ORG Key I-ORG Laboratory I-ORG for I-ORG Endocrine I-ORG and I-ORG Metabolic I-ORG Diseases I-ORG of I-ORG Ministry I-ORG of I-ORG Health I-ORG 1994DP131044 O the B-ORG National I-ORG Key I-ORG New I-ORG Drug I-ORG Creation I-ORG and I-ORG Manufacturing I-ORG Program I-ORG of I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2012ZX09303006-001 O the B-ORG National I-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 863 O Program O 2011AA020107 B-AWARD National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG 288 I-ORG 2011ZX09307-001-08 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O U1604172 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Henan I-ORG Province I-ORG co-established I-ORG by I-ORG the I-ORG province I-ORG and I-ORG the I-ORG ministry I-ORG No. O 201701002 O and O the O Science B-ORG and I-ORG Technology I-ORG Colleges I-ORG Innovation I-ORG Team I-ORG Support I-ORG Program I-ORG of I-ORG Henan I-ORG Province I-ORG No. O 18IRTSTHN024 O This O research O was O supported O by O Program B-ORG of I-ORG International I-ORG Science I-ORG and I-ORG Technology I-ORG Cooperation I-ORG 2011DFB31580 O the B-ORG National I-ORG Key I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2012BAD38B03 O and O the B-ORG Project I-ORG of I-ORG the I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2013C02019-1 O This O study O was O supported O by O the O Specialized O Research O Fund O for O the O Doctoral B-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG 20110141110019 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 31270278 B-AWARD and O 31570220 B-AWARD the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG No. O XDPB02 B-AWARD and O the O Wuhan B-ORG Botanical I-ORG Garden I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG No. O Y655261W03 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31100072 O 41776175 B-AWARD and O 31600286 B-AWARD and O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG CAAS-ASTIP-2013-OCRI O JJ, O FR, O and O EM O were O supported O by O Agence B-ORG Nationale I-ORG de I-ORG la I-ORG Recherche I-ORG ANR-10-LABEX-04 O GRAL I-AWARD Labex O Grenoble O Alliance O for O Integrated O Structural O Cell O Biology O ANR-11-BTBR-0008 B-AWARD Océanomics O IDEX O UGA O CDP O Glyco@Alps O Institut O Carnot O 3BCAR O This O work O was O financially O supported O by O the B-ORG Chinese I-ORG Academic I-ORG Project I-ORG B I-ORG XDB15030103 O National B-ORG Project I-ORG 2016YFC0501202 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41571255 O 31370144 O and O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jilin I-ORG Province I-ORG 20140101017JC O Science B-ORG and I-ORG Technology I-ORG Development I-ORG Project I-ORG of I-ORG Jilin I-ORG Province I-ORG 20180519002JH O the B-ORG Key I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG KFZD-SW-112 O the O Natural O Science O Foundation O of O Jilin O Province O 20140101017JC O and O the O 135 O Project O of O Northeast O Institute O of O Geography O and O Agroecology O Y6H2043001 O This O work O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51871069 O Fundamental O Research O Funds O for O the O Central O Universities O 3072019CF1004 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG of O China O E2017030 O and O Foundation O of O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Rare I-ORG Earth I-ORG Resources I-ORG Utilization I-ORG RERU2018017 O The O authors O thank O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 21977001 B-AWARD and O 21602029 B-AWARD the O Horizontal B-ORG cooperation I-ORG project I-ORG of I-ORG Fuyang I-ORG municipal I-ORG government I-ORG Nos O XDHX201722 B-AWARD and O XDHX2016026 B-AWARD Anhui B-ORG Province I-ORG Foundation I-ORG No. O 18030701213 B-AWARD Horizontal B-ORG cooperation I-ORG project I-ORG of I-ORG Yifan I-ORG Pharmaceutical I-ORG Co I-ORG Ltd I-ORG HX2019033 O and O Technological B-ORG Fund I-ORG of I-ORG Fuyang I-ORG normal I-ORG university I-ORG 2017FSKJ16 O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 42177361 O This O work O is O supported O by O a O special O fund O of O Beijing B-ORG Key I-ORG Laboratory I-ORG of I-ORG Indoor I-ORG Air I-ORG Quality I-ORG Evaluation I-ORG and I-ORG Control I-ORG No. O BZ0344KF21-06 B-AWARD and O by O the O Fundamental B-ORG Research I-ORG Funds O for O the O Central O Universities O FRF-TP-18-071A1 O This O research O was O funded O by O the O Graduate B-ORG Student I-ORG Scientific I-ORG Research I-ORG Innovation I-ORG Projects I-ORG in I-ORG Jiangsu I-ORG province I-ORG Project O Number O SJCX22-XY054 B-AWARD the O Open B-ORG Fund I-ORG of I-ORG Key I-ORG Laboratory I-ORG for I-ORG Advanced I-ORG Technology I-ORG in I-ORG Environmental I-ORG Protection I-ORG of I-ORG Jiangsu I-ORG Province I-ORG JBGS026 O and O the O Industry–Academia–Research B-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province O grant O number O BY2022456 B-AWARD This O research O was O supported O in O part O by O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG under O grant O 2018ZX10715003-002 B-AWARD WY O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG under O grant O 2017YFC1703900 B-AWARD SY O the O Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG under O grant O 2018PTDJ0084 B-AWARD YL O and O the O US O National B-ORG Science I-ORG Foundation I-ORG NSF O under O grant O 1652107 B-AWARD XW O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O work O of O Katerina O Sam O was O supported O by O Czech B-ORG Science I-ORG Foundation I-ORG Grants O 18-23794Y B-AWARD and O the O infrastructure O and O logistics O of O the O project O was O financially O supported O by O the O European B-ORG Science I-ORG Foundation I-ORG 669609 B-AWARD grant O the O Darwin B-ORG Initiative I-ORG for I-ORG the I-ORG Survival I-ORG of I-ORG Species I-ORG grant O 22-002 B-AWARD and O the O Christensen B-ORG Foundation I-ORG grant O 2016-8734 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O CAMS O Innovation O Fund O for O Medical O Science O CAMS-I2M,2016-I2M-3-021 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.819272949 O Sub-Item B-ORG of I-ORG the I-ORG Important I-ORG and I-ORG Special I-ORG Project I-ORG of I-ORG the I-ORG Science I-ORG and I-ORG Technology I-ORG Ministry I-ORG of I-ORG China I-ORG No.2018ZX10734404 O and O the O Basical B-ORG Scientific I-ORG Research I-ORG Fund I-ORG Projects I-ORG of I-ORG Chinese B-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG No.2018PT31013 O The O funders O had O no O role O in O study O design O data O collection O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O byAcademia O Sinica O Taipei O TaiwangrantAS‐iMATE‐107‐31;National O Health I-ORG Research I-ORG InstitutesgrantNHRI‐EX105‐10507EC O NHRI‐EX106‐10507EC I-AWARD NHRI‐EX107‐10507EC;Taipei O Veterans I-ORG General I-ORG Hospital O TaiwangrantV104‐B015 O V105C‐166 I-AWARD V106C‐153 I-AWARD V107C‐152 I-AWARD VGHUST106‐G7‐5‐1 I-AWARD VGHUST107‐G7‐1‐3;2017 O Global O ASPIRE O Transthyretin O TTR O Amyloidosis O Competitive O Research O Grant O AwardsgrantWI229986;Ministry O of I-ORG Science I-ORG and I-ORG Technology I-ORG TaiwangrantsMOST O 105‐2314‐B‐075 I-AWARD ‐066and105‐2113‐M‐001 O ‐021 I-AWARD ‐MY2;Yen O Tjing I-ORG Ling I-ORG Medical I-ORG FoundationgrantCI‐106‐6 O This O research O was O supported O by O Basic B-ORG Science I-ORG Research I-ORG Program I-ORG through I-ORG the I-ORG National I-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O funded O by O the O Ministry O of O Education O NRF-2020R1I1A2066868 O the O National O Research O Foundation O of O Korea O NRF O grant O funded O by O the O Korea O government O MSIT O No. O 2020R1A5A2019413 B-AWARD a O grant O of O the O Korea O Health O Technology O R&D O Project O through O the O Korea O Health O Industry O Development O Institute O KHIDI O funded O by O the O Ministry B-ORG of I-ORG Health I-ORG I-ORG Welfare I-ORG Republic I-ORG of I-ORG Korea I-ORG grant O number O HF20C0038 B-AWARD and O the O innovation O network O support O Program O through O the O INNOPOLIS O funded O by O Ministry B-ORG of I-ORG Science I-ORG and I-ORG ICT I-ORG 2022-IT-RD-0205-01-101 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O to O MQ O Shahid O 31850410472 O the O Guangzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Key I-ORG Program I-ORG to O XD O Liu O 201707020015 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG of I-ORG China I-ORG to O MQ O Shahid O 2017A030313142 O This O work O was O funded O by O Agriculture B-ORG and I-ORG Agri-Food I-ORG Canada’s O Genomics O Research O and O Development O Initiative O and O AgriInnovation O Program O Projects O J-000008 B-AWARD and O J-001580 B-AWARD and O by O the O Canadian B-ORG National I-ORG Wheat I-ORG Improvement I-ORG Program I-ORG Cluster I-ORG Project O J-000412 B-AWARD X.H O was O funded O by O the O China B-ORG Scholarship I-ORG Council I-ORG under O the O MOE-AAFC O Program O Funding O bodies O played O no O role O in O the O design O of O the O study O nor O in O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O The O study O was O financially O supported O by O grants O from O the B-ORG Administration I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Province O Program O Number O 2010ZA057 B-AWARD 2014ZB060 B-AWARD the B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG the I-ORG Health I-ORG Department I-ORG of I-ORG Zhejiang I-ORG Province O Program O Number O 2013KYA071 B-AWARD and O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O Program O Number O 81471532 B-AWARD 81402353 B-AWARD This O project O was O funded O through O NIH B-ORG grant I-ORG GM59962 B-AWARD and O the O NSF B-ORG PGRP I-ORG grant I-ORG IOS-1237975 B-AWARD Benjamin O Schwessinger O was O supported O by O a O Human B-ORG Frontiers I-ORG Science I-ORG Program I-ORG long-term I-ORG postdoctoral I-ORG fellowship I-ORG LT000674/2012 O and O a O Discovery B-ORG Early I-ORG Career I-ORG Research I-ORG Award I-ORG DE150101897 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 32102541 B-AWARD and O 32160787 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Province I-ORG grant O number O 20212BAB215016 B-AWARD the O Technology B-ORG System I-ORG of I-ORG Modern I-ORG Agricultural I-ORG Poultry I-ORG Industry I-ORG of I-ORG Jiangxi I-ORG Province I-ORG JXARS-09 O and O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Jiangxi I-ORG Provincial I-ORG Education I-ORG Department I-ORG grant O numbers O GJJ210407 B-AWARD and O GJJ190243 B-AWARD This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG program I-ORG of I-ORG China I-ORG grant O no. O 2016YFD0500307 B-AWARD CS O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 81772205 B-AWARD CS I-AWARD and O grant O no. O 81361128017 B-AWARD CS O and O the O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG grant O no. O 2016-12M-2-002 B-AWARD LX) O to O CS. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Project O No. O 31800012 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangzhou I-ORG No. O 201804020018 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG No. O 2018A0303130164 B-AWARD and O GDAS’ B-ORG Special I-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG No. O 2020GDASYL-20200104011 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFA0104100 O and O Shenzhen B-ORG Engineering I-ORG Laboratory I-ORG for I-ORG Innovative I-ORG Molecular I-ORG Diagnostics I-ORG grant O DRC-SZ B-AWARD 2016 I-AWARD 884 O funded O by O Development O and O Reform O Commission O of O Shenzhen O Municipality O and O Shenzhen B-ORG Key I-ORG Laboratory I-ORG of I-ORG Neurogenomics I-ORG CXB201108250094A O funded O by O Science O Technology O and O Innovation O Commission O of O Shenzhen O Municipality O D.C O is O supported O by O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG grant O 2017M622795 B-AWARD The O work O at O the O HZI O was O mainly O supported O in O part O by O grants O from O the O EU B-ORG PANFLUVAC O 044115 I-AWARD and O TRANSVAC B-AWARD 228403 O and O BMBF O in O the O context O of O the O programs O Gerontosys B-ORG 2 I-ORG Gerontoshield O 0315890 O and O EuroNanoMed B-ORG HCVAX O 13N11739 O In O addition O M.V.S O was O in O part O supported O by O a O fellowship O from O the O German O Academic O Exchange O Service O DAAD O and O a O fellowship O from O the O National B-ORG Scientific I-ORG and I-ORG Technical I-ORG Research I-ORG Council I-ORG CONICET O Argentina O ANPCYT O FONCYT/PICT B-AWARD 04393-2018 O This O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grants O #81572233 O 91420301 O 61403367 O the O Shenzhen B-ORG Basic I-ORG Research I-ORG Grant I-ORG #JCYJ20150401150223634 O the O Shenzhen B-ORG High-level I-ORG Oversea I-ORG Talent I-ORG Program I-ORG Shenzhen I-ORG Peacock I-ORG Plan I-ORG Grants O #KQCX2015033117354152 O KQJSCX20160301141522 O the O Shenzhen B-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG Scientific I-ORG Research I-ORG Project I-ORG SZXJ2017072 O and O the O Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Nanshan I-ORG District I-ORG #2017012 O This O research O was O funded O by O Jiangxi B-ORG Province I-ORG Key I-ORG R&D I-ORG Program I-ORG Project I-ORG 20202BBGL73016 O Jiangxi B-ORG Clinical I-ORG Research I-ORG Center I-ORG for I-ORG Gastroenterology I-ORG 20201ZDG02007 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81860122 O and O Jiangxi B-ORG Province I-ORG Outstanding I-ORG Youth I-ORG Talent I-ORG Funding I-ORG Program I-ORG 20192BCBL23021 O This O study O was O supported O by O grants O to O Jun O Liu O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81372919 B-AWARD Guangzhou B-ORG Science I-ORG Technology I-ORG and I-ORG Innovation I-ORG Commission I-ORG No. O 201604020100 B-AWARD Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG 201601010270 O 2017010160489 B-AWARD 201704030083 B-AWARD Pearl B-ORG River I-ORG S&T I-ORG Nova I-ORG Program I-ORG of I-ORG Guangzhou I-ORG 201710010155 O 201806010072 B-AWARD and O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Guangdong I-ORG province I-ORG 2015A010101313 O 2017A050506011 B-AWARD 2017B090911012 B-AWARD CJ O was O supported O by O a O Career O Development O Award O from O the O Medical B-ORG Research I-ORG Council I-ORG Grant O G0800311 B-AWARD and O a O grant O from O the O Rosetrees B-ORG Trust I-ORG and O the O Stoneygate O Trust O M370 O MiP O was O supported O by O a O PhD O Fellowship O from O the O National B-ORG Heart I-ORG and I-ORG Lung I-ORG Institute I-ORG Foundation O registered O charity O number O 1048073 B-AWARD FK O was O supported O by O a O Wellcome O Trust O grant O 109058/Z/15/Z O and O AV O by O European O Respiratory O Society O and O the O Asociación O Latinoamericana O de O Tórax O joint O long-term O Research O Fellowship O 2019 O Number O LTRF O 201901-00546 O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81770566 B-AWARD 82000599 O NHC B-ORG Key I-ORG Laboratory I-ORG of I-ORG Echinococcosis I-ORG Prevention I-ORG and I-ORG Control I-ORG No. O 2021WZK1004 B-AWARD and O Health B-ORG Commission I-ORG of I-ORG the I-ORG Tibet I-ORG Autonomous I-ORG Region I-ORG No. O 311220432 B-AWARD This O research O was O funded O by O “Yangfan B-ORG Plan” I-ORG Innovation I-ORG Team I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017YT05N093 O State’s B-ORG Key I-ORG Project I-ORG of I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG China I-ORG 2020YFC1908900 O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG 2021A1515012263 O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG China I-ORG 202002030365 O and O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG 2021B1515020068 O This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2021YFB3200402 O the O Natural B-ORG Science I-ORG Foundation I-ORG Committee I-ORG NSFC O Grant O Nos O 62020106006 B-AWARD and O 62101208 B-AWARD and O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2021M691196 O This O study O was O supported O by O grants O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC1004800 O the O Key B-ORG Projects I-ORG Jointly I-ORG Constructed I-ORG by I-ORG the I-ORG Ministry I-ORG and I-ORG the I-ORG Province I-ORG of I-ORG Zhejiang I-ORG Medical I-ORG and I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG WKJ-ZJ-2005 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82071640 O 31701260 B-AWARD This O work O was O supported O by O the O 100th O Anniversary O Chulalongkorn O University O Fund O for O a O doctoral O scholarship O to O Supansa O Tuanthap O in O the O Inter-Department O Program O of O Biomedical O Sciences O Faculty O of O Graduate O School O Chulalongkorn O University O Bangkok O Thailand O the O National O Research O Council O of O Thailand O the O Research O Chair O Grant O from O NSTDA B-ORG P-15-50004 O the O Thailand B-ORG Research I-ORG Fund I-ORG RTA6080012 O and O the O Center B-ORG of I-ORG Excellence I-ORG in I-ORG Clinical I-ORG Virology I-ORG GCE O 59-009-30-005 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2017BC082 O the O Specific O Funds O of O the O Central B-ORG Guidance I-ORG for I-ORG Local I-ORG Science I-ORG and I-ORG Technology I-ORG Taishan I-ORG Scholars I-ORG Project I-ORG ts201712080 O Agricultural B-ORG Science I-ORG and I-ORG Technological I-ORG Innovation I-ORG Project I-ORG of I-ORG Shandong I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Science I-ORG CXGC2018E21 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31902062 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0503104 O Guangdong B-ORG Key I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2018B020202001 B-AWARD 2017A020208036 I-AWARD 2017B090901050 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2018A030313686 O and O Guangdong O Modern O Agricultural O Industry O Technology O System O Program O 2018LM2176 O 2018LM1142 O Biological O Resources O Program O Chinese O Academy O of O Sciences O KFJ-BRP-007 O Guangzhou O Science O and O Technology O Program O 201904010305),Guangdong O Provincial O Key O Laboratory O of O Applied O Botany O South O China O Botanical O Garden O Chinese O Academy O of O Sciences O AB2018002 O AB2018026 O The O Project O was O also O supported O by O Program O from O Core O Botanical O Gardens O Chinese O Academy O of O Sciences O The O funding O bodies O played O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81172266 O the O Science B-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BE2010719 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK2011859 O and O the O Jiangsu B-ORG Innovation I-ORG of I-ORG Medical I-ORG Team I-ORG and I-ORG Leading I-ORG Talents I-ORG Cultivation I-ORG LJ201127 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Science B-ORG and I-ORG Technology I-ORG Fundamental I-ORG Resources I-ORG Investigation I-ORG Program I-ORG 2022FY100904 O the O Research B-ORG Units I-ORG of I-ORG Adaptive I-ORG Evolution I-ORG and I-ORG Control I-ORG of I-ORG Emerging I-ORG Viruses I-ORG Chinese I-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG 2018RU009 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2021YFC0863400 O 2022YFC2604100 B-AWARD and O the O Innovation B-ORG Team I-ORG and I-ORG Talents I-ORG Cultivation I-ORG Program I-ORG of I-ORG the I-ORG National I-ORG Administration I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG ZYYCXTD-D-202208 O This O work O was O supported O by O German B-ORG Research I-ORG Council I-ORG DFG-Unite O and O intramural O funds O from O National B-ORG Center I-ORG for I-ORG Tumor I-ORG diseases I-ORG NCT3.0_2015.21/22 O NCT-PRO I-AWARD and I-AWARD Biodose I-AWARD programs O This O work O was O supported O in O part O by O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH-1P01CA257904-01A1 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O project O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81902225 O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG LQ18H060002 O and O Zhejiang B-ORG Medical I-ORG and I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 2019KY384 O This O work O was O financially O supported O by O the B-ORG Lingang I-ORG Laboratory I-ORG Grant O No. O LG-QS-202205-11 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 82272857 B-AWARD and O the B-ORG Shanghai I-ORG Committee I-ORG of I-ORG Science I-ORG and I-ORG Technology O China O Grant O No. O 19411951700 B-AWARD This O study O was O supported O by O a O grant O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.31660728 O a O grant O from O the O project O for O the B-ORG First-class I-ORG discipline I-ORG construction I-ORG Biology I-ORG of I-ORG Ningxia I-ORG Universities I-ORG NXYLXK2017B05 O Major B-ORG Innovation I-ORG Projects I-ORG for I-ORG Building I-ORG First-class I-ORG Universities I-ORG in I-ORG Western I-ORG China I-ORG ZKZD2017001 O and O a O grant O from O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Ningxia I-ORG NZ15017 O These O funding O play O no O role O in O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 51502272 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG grant O number O LY19E080003 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG China I-ORG University I-ORG of I-ORG Geosciences I-ORG Wuhan O grant O number O G1323511668 B-AWARD Opening O Fund O of O State O Key O Laboratory O of O Silicate O Materials O for O Architectures O Wuhan O University O of O Technology O grant O number O SYSJJ2018-15 B-AWARD Opening O Fund O of O Engineering O Research O Center O of O Nano-Geo O Materials O of O Ministry O of O Education O China O University O of O Geosciences O grant O number O NGM2018KF011 B-AWARD and O Science O and O Technology O Project O of O Hubei O Transportation O Department O grant O number O 2017-538-1-1 O This O research O was O supported O by O the O Australian B-ORG Research I-ORG Council I-ORG DP160102400 O the O Australian B-ORG National I-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG 1078037 O 1078901 I-AWARD 1103418 I-AWARD 1107258 I-AWARD 1127440 I-AWARD and I-AWARD 1113400 O and O the O Sylvia O O Charles O Viertel O Charitable O Foundation O Riccardo O Marioni O was O supported O by O Alzheimer’s B-ORG Research I-ORG UK I-ORG Major I-ORG Project I-ORG Grant I-ORG ARUK-PG2017B-10 O Generation O Scotland O received O core O support O from O the O Chief B-ORG Scientist I-ORG Office I-ORG of I-ORG the I-ORG Scottish I-ORG Government I-ORG Health I-ORG Directorates I-ORG CZD/16/6 O and O the O Scottish B-ORG Funding I-ORG Council I-ORG HR03006 O Genotyping O and O DNA O methylation O profiling O of O the O GS:SFHS O samples O was O carried O out O by O the O Genetics O Core O Laboratory O at O the O Wellcome O Trust O Clinical O Research O Facility O Edinburgh O Scotland O and O was O funded O by O the O Medical B-ORG Research I-ORG Council I-ORG UK I-ORG and I-ORG the I-ORG Wellcome I-ORG Trust I-ORG Wellcome O Trust O Strategic O Award O “STratifying O Resilience O and O Depression O Longitudinally” O (STRADL O Reference O 104036/Z/14/Z B-AWARD This O research O was O supported O by O a O grant O from O the O National B-ORG Institute I-ORG of I-ORG Biological I-ORG Resources I-ORG NIBR O funded O by O the O Ministry O of O Environment O MOE O of O the O Republic O of O Korea O grant O number O NIBR201928201 B-AWARD and O funded O by O Cooperative O Research O Program O for O Agriculture O Science O O Technology O Development O of O Rural B-ORG Development I-ORG Administration O Republic O of O Korea O grant O number O PJ012653 B-AWARD This O research O also O was O supported O by O the O Collaborative O Genome O Program O of O the O Korea O Institute O of O Marine O Science O and O Technology O Promotion O KIMST O funded O by O the O Ministry B-ORG of I-ORG Oceans I-ORG and I-ORG Fisheries I-ORG MOF O grant O number O 20180430 B-AWARD This O work O was O supported O by O National B-ORG Science I-ORG Foundation I-ORG Cooperative I-ORG agreement I-ORG no. O DBI-0939454 B-AWARD BEACON O Center O National B-ORG Institutes I-ORG of I-ORG Health I-ORG Grants I-ORG R01 B-AWARD GM088344 O and O Army B-ORG Research I-ORG Office I-ORG Grant I-ORG W911NF-12-1-0390 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG 2018ZX10101004 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81372043 O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 7162199 O and O Interdisciplinary O medicine O seed O Fund O of O Peking O University O BMU2018MX014 O All O the O funding O bodies O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG grant O number O 2016YFC1101103 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Fund I-ORG grant O number O 81970843 B-AWARD the B-ORG Project I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Plan I-ORG of I-ORG Southwest I-ORG Hospital I-ORG grant O number O SWH2017JCZD-08 B-AWARD and O the B-ORG National I-ORG Science I-ORG Fund I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG grant O number O 31625011 B-AWARD This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 21337001 B-AWARD and O 21607011 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province O grant O number O ZR2018MB043 B-AWARD the B-ORG Fundamental I-ORG Research I-ORG Fund I-ORG of I-ORG Shandong I-ORG University O grant O number O 2018JC027 B-AWARD and O Focus O on O research O and O development O plan O in O Shandong O province O grant O number O 2019GSF109037 O ZonMW B-ORG 40-42600-98-417 O NWO B-ORG 313-99-310 O and O the B-ORG Federal I-ORG State I-ORG of I-ORG Lower I-ORG Saxony I-ORG R2N O provided O funding O for O this O project O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31872475 O Sichuan B-ORG Veterinary I-ORG Medicine I-ORG and I-ORG Drug I-ORG Innovation I-ORG Group I-ORG of I-ORG China I-ORG Agricultural I-ORG Research I-ORG System I-ORG CARSSVDIP O China O Agricultural O Research O System O CARS-42-17 O and O Sichuan B-ORG Province I-ORG Research I-ORG Programs I-ORG 2017JY0014 O This O research O was O funded O by O Project B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2013B022000003 O Key B-ORG project I-ORG of I-ORG Dongguan I-ORG City I-ORG 201310810102 O and O Medical B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG A2014860 O The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O financial O support O of O the O Science O and O Technology O Planning O Project O of O Sichuan O Province O of O China O 2016NYZ0053-4 O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O responsible O person O of O the O Science O and O Technology O Planning O Project O of O Sichuan O Province O of O China O 2016NYZ0053-4 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31571661 B-AWARD Science B-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Sichuan I-ORG Province I-ORG of I-ORG China I-ORG 2017JY0012 B-AWARD Specific B-ORG Foundation I-ORG of I-ORG Agronomy I-ORG nyhyzx3-15 B-AWARD is O Min O Zhang O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O a O grant O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41506170 O 31672672 B-AWARD and O 31872195 B-AWARD Shandong B-ORG Province I-ORG Key I-ORG Research I-ORG and I-ORG Invention I-ORG Program I-ORG 2017GHY15102 O 2017GHY15106 B-AWARD Qingdao B-ORG Source I-ORG Innovation I-ORG Program I-ORG 17-1-1-57-jch O Marine B-ORG Fishery I-ORG Institute I-ORG of I-ORG Zhejiang I-ORG Province I-ORG Key I-ORG Laboratory I-ORG of I-ORG Mariculture I-ORG and I-ORG Enhancement I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2016KF002 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2018YFD0901204 O STS B-ORG project I-ORG KFZD-SW-106 O ZSSD-019 B-AWARD Qingdao B-ORG National I-ORG Laboratory I-ORG for I-ORG Marine I-ORG Science I-ORG and I-ORG Technology I-ORG 2015ASKJ02 O and O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-47 O This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81903842 O 81573953 B-AWARD 81703753 O 81973634 B-AWARD Zhejiang B-ORG Chinese I-ORG Medical I-ORG University I-ORG Startup O Funding O 111100E014 O Zhejiang B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG 2018C37045 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG LY18H290006 O Zhejiang B-ORG Provincial I-ORG Medical I-ORG and I-ORG Healthy I-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG WKJ-ZJ-1728 O 2016KYB220 O and O Program B-ORG of I-ORG Zhejiang I-ORG Provincial I-ORG TCM I-ORG Sci-tech I-ORG Plan I-ORG 2016ZZ012 O 2018ZY006 I-AWARD 2018ZB044 I-AWARD 2019ZZ010 O 2020ZZ005 B-AWARD This O work O was O supported O by O the O USDA B-ORG National I-ORG Institute I-ORG of I-ORG Food I-ORG and I-ORG Agriculture I-ORG under O award O numbers O 2017-67013-26195 B-AWARD and O 2021-67013-33840 B-AWARD to O Y.W O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 3220249317 B-AWARD to O H.L O and O 32172588 B-AWARD to O Z.W O and O HAAFS B-ORG International I-ORG Science I-ORG and I-ORG Technology I-ORG Cooperation I-ORG Project I-ORG 2023-KJCXZX-JZS-GH01 O to O Z.W O USDA O is O an O equal O opportunity O provider O and O employer O The O present O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 81373627 B-AWARD 81774300 B-AWARD the B-ORG science I-ORG and I-ORG technology I-ORG research I-ORG project I-ORG of I-ORG Henan I-ORG province I-ORG Grant O No. O 182102310595 B-AWARD and O the B-ORG Open I-ORG Project I-ORG Fund I-ORG of I-ORG Henan I-ORG Key I-ORG Laboratory I-ORG of I-ORG Zhang I-ORG Zhongjing I-ORG Formulae I-ORG and I-ORG Herbs I-ORG for I-ORG Immunoregulation I-ORG Grant O No. O kfkt201703 B-AWARD Dr. O NQ O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31670118 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG LR15H030002 O Dr. O WF O was O supported O by O the B-ORG Key I-ORG Subject I-ORG of I-ORG Clinical I-ORG Medical I-ORG Engineering I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. O G3221 O S&T B-ORG Major I-ORG Project I-ORG of I-ORG China I-ORG 2017ZX10203205 O and O the B-ORG Major I-ORG Scientific I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2017C03028 O This O work O was O supported O in O part O by O Jiangsu B-ORG Provincial I-ORG Medical I-ORG Youth I-ORG Talent I-ORG QNRC2016034 O Jiangsu B-ORG Province I-ORG Health I-ORG Department I-ORG Program I-ORG Grant I-ORG Z201411 O Key B-ORG Project I-ORG supported I-ORG by I-ORG Medical I-ORG Science I-ORG and I-ORG technology I-ORG development I-ORG Foundation I-ORG Nanjing I-ORG Department I-ORG of I-ORG Health I-ORG JQX14006 O This O work O was O supported O by O the O Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation O China O ZR2016EMB09 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51703102 O 51373082 B-AWARD and O 51673103 O and O the O Shandong B-ORG Provincial I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG 2016GGX102011 O and O 2018GGX103049 B-AWARD This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81471690 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG for I-ORG Young I-ORG Scientists I-ORG No. O 81701734 B-AWARD the O 5th O phase O “333 O talent O project” O training O funds O of O Jiangsu O province O Science B-ORG and I-ORG Technology I-ORG Plan I-ORG of I-ORG Jiangsu I-ORG Province-Standardization I-ORG of I-ORG Diagnosis I-ORG and I-ORG Treatment I-ORG of I-ORG Key I-ORG Diseases I-ORG Project I-ORG No. O BE2015635 B-AWARD and O Key B-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Fund I-ORG of I-ORG Nanjing I-ORG Medical I-ORG University I-ORG No. O 2017NJMUZD039 B-AWARD None O of O these O agencies O were O involved O in O designing O analyzing O or O interpreting O the O study O results O N.M.W O is O supported O by O a O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG Early I-ORG Career I-ORG Fellowship I-ORG grant O number O APP1104818 B-AWARD D.M.E O is O funded O by O an O Australian B-ORG Research I-ORG Council I-ORG Future I-ORG Fellowship I-ORG grant O number O FT130101709 B-AWARD and O a O Medical B-ORG Research I-ORG Council I-ORG programme I-ORG grant I-ORG grant O number O MC_UU_12013/4 B-AWARD Access O to O the O UKBB O study O data O was O funded O by O University B-ORG of I-ORG Queensland I-ORG Early I-ORG Career I-ORG Researcher I-ORG Grant I-ORG 2014002959 O This O study O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32072257 O Training B-ORG plan I-ORG for I-ORG academic I-ORG and I-ORG technical I-ORG leaders I-ORG of I-ORG major I-ORG disciplines I-ORG in I-ORG Jiangxi I-ORG Province-Young I-ORG Talents I-ORG Project I-ORG 20212BCJ23037 O and O the O Graduate B-ORG Innovation I-ORG Special I-ORG Fund I-ORG of I-ORG Jiangxi I-ORG Province I-ORG YC2021-S041 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31811530297 O and O Guangdong B-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Applied I-ORG Botany I-ORG South I-ORG China I-ORG Botanical I-ORG Garden I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG AB2018014 O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG 201707020035 O and O Chang O Hungta O Science O Foundation O of O Sun O Yat-sen O University O The O funding O body O played O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 51675393 B-AWARD Engineering B-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG EPSRC O grant O no. O EP/N018524/1 B-AWARD the O Royal B-ORG Society I-ORG grant O no. O IEC\NSFC\181018 B-AWARD the B-ORG Special I-ORG Fund I-ORG for I-ORG Key I-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Hubei I-ORG Province I-ORG grant O no. O 2017AAA111 B-AWARD the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG grant O no. O 2016-YB-021 B-AWARD and O the O Chinese B-ORG Government I-ORG Scholarship I-ORG by I-ORG the I-ORG China I-ORG Scholarship I-ORG Council I-ORG grant O no. O 201706950051 B-AWARD This O work O was O supported O by O grants O from O the B-ORG National I-ORG Science I-ORG I-ORG Technology I-ORG Pillar I-ORG Program I-ORG during I-ORG the I-ORG Twelfth I-ORG Five-year I-ORG Plan I-ORG Period I-ORG 2014BAI09B10 O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017A030312003 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81572658 O the B-ORG Program I-ORG of I-ORG Introducing I-ORG Talents I-ORG of I-ORG Discipline I-ORG to I-ORG Universities I-ORG B14035 O and O the B-ORG Innovation I-ORG Team I-ORG Development I-ORG Plan I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG No. O IRT_17R110 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31701898 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province O China O BK20160567 O the O Science O Fund O of O Jiangsu O Vocational O College O of O Agriculture O and O Forestry O 2017kj06 O 2019kj011 O the O Six B-ORG Talent I-ORG Peaks I-ORG Project I-ORG in I-ORG Jiangsu I-ORG Province I-ORG NY-019 O NY-156 O and O the O Blue O Project O of O Jiangsu O Province O This O study O was O supported O by O Tianjin B-ORG Research I-ORG Program I-ORG of I-ORG Application I-ORG Foundation I-ORG and I-ORG Advanced I-ORG Technology I-ORG number O 14CYBJC29800 B-AWARD Tianjin B-ORG Municipal I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O 17JCYBJC26000 B-AWARD and O Science B-ORG and I-ORG technology I-ORG innovation I-ORG fund I-ORG projects I-ORG of I-ORG Tianjin I-ORG Institute I-ORG of I-ORG Urology I-ORG number O MNYB201503 B-AWARD The O funding O bodies O played O no O role O in O the O design O of O the O study O data O collection O analysis O or O interpretation O of O data O This O work O was O supported O by O a O shared O PhD O studentship O between O the O Medical O and O Dental O Schools O at O Cardiff O University O to O Ann O Ager O and O Vera O Knäuper O Vera O Knäuper O was O supported O by O Cancer B-ORG Research I-ORG UK I-ORG C28140/A9961 O and O by O the O Arthritis B-ORG Research I-ORG UK I-ORG 17503 O Ann O Ager O was O supported O by O project O grants O from O the O Wellcome B-ORG Trust I-ORG 094511/Z/10/Z O and O the O Medical B-ORG Research I-ORG Council I-ORG UK I-ORG MR/L008742/1 O This O research O was O founded O by O Haitao O Ding O of O the O National B-ORG Natural I-ORG Science I-ORG Joint I-ORG Fund I-ORG Project O grant O number O U1864206 B-AWARD Niaona O Zhang O of O the O Jilin B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Plan I-ORG Project O grant O number O 20220203166SF B-AWARD Niaona O Zhang O of O the O Open O Fund O of O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Automotive I-ORG Simulation I-ORG and I-ORG Control I-ORG of I-ORG Jilin I-ORG University O grant O number O 20210237 B-AWARD This O study O was O supported O by O VectorNet B-ORG and O its O funding O agencies O ECDC O and O EFSA O contract O number O OC/EFSA/AHAW/2013/02 B-AWARD FS O was O partially O funded O by O the O European B-ORG Commission I-ORG Framework I-ORG Program I-ORG Seven I-ORG Award I-ORG “InfraVec” I-ORG project O number O 228421 B-AWARD and O by O Elanco B-ORG Animal I-ORG Health I-ORG project O number O BIOIT140021 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31801368 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG province I-ORG of I-ORG China I-ORG 2022-NLTS-19-02 O and O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2022MD713775 O S.S.K O was O supported O by O Natural B-ORG Environment I-ORG Research I-ORG Council I-ORG NERC I-ORG Advanced O Fellowship O NE/J019100/1 B-AWARD and O European B-ORG Research I-ORG Council I-ORG Starting O grant O no. O 640004 B-AWARD S.J.C O was O supported O by O the O Natural B-ORG Sciences I-ORG and I-ORG Engineering I-ORG Research I-ORG Council I-ORG NSERC I-ORG and I-ORG the I-ORG Canada I-ORG Research I-ORG Chairs I-ORG Program O B.A O was O supported O by O a O NERC O standard O grant O NE/K00400X/1 B-AWARD This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O 2019YFA0904800 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grants O 81872800 I-AWARD and O 82173746 B-AWARD and O the O 111 B-ORG Project I-ORG Grant O BP0719034 O This O research O was O funded O by O the O National B-ORG Institute I-ORG of I-ORG Advanced I-ORG Analytical I-ORG Science I-ORG and I-ORG Technology I-ORG INCTAA O CNPq O 573894/2008-6 I-AWARD and O FAPESP B-AWARD 2008/57808-1 O and O the O National B-ORG Council I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Development I-ORG CNPq O 407080/2021-0 O 306054/2020-5 B-AWARD and O S. B-AWARD Cadore I-AWARD productivity I-AWARD grant O This O study O was O financed O in O part O by O the O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior—Brasil I-ORG CAPES)—Finance O Code O 001 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 51375460 B-AWARD Young B-ORG talent I-ORG training I-ORG project I-ORG of I-ORG Zhejiang I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences(2016R23R08E05 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG grant O no. O LQ17C150003 B-AWARD Scientific B-ORG and I-ORG Technological I-ORG Program I-ORG of I-ORG Hangzhou I-ORG 2015R23A70D05 O This O research O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 21672082 B-AWARD 31671214 B-AWARD Shandong B-ORG Key I-ORG Development I-ORG Project I-ORG No. O 2016GSF201209 B-AWARD the O Young B-ORG Taishan I-ORG Scholars I-ORG Program I-ORG No. O tsqn20161037 B-AWARD Shandong B-ORG Talents I-ORG Team I-ORG Cultivation I-ORG Plan I-ORG of I-ORG University I-ORG Preponderant I-ORG Discipline I-ORG No. O 10027 B-AWARD Fund B-ORG of I-ORG Shandong I-ORG Province I-ORG Natural I-ORG Science I-ORG Foundation I-ORG ZR2017BH038 O Scientific B-ORG Research I-ORG fund I-ORG of I-ORG University I-ORG of I-ORG Jinan I-ORG Nos O XKY1609 B-AWARD 160100202 B-AWARD the O Shanghai B-ORG “ChenGuang” I-ORG Project I-ORG No. O 16CG42 B-AWARD and O the O Shanghai B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG No. O 2017YQ052 B-AWARD and O by O the O Brazilian B-ORG Government I-ORG Agencies I-ORG FAP/DF I-ORG No. O 0193.001020/2015 I-AWARD and O CNPq B-ORG No. O 447.628/2014-3 B-AWARD S.S.C.R O is O funded O by O a O strategic O award O from O the O Wellcome B-ORG Trust I-ORG for O the O Centre O for O Immunity O Infection O and O Evolution O no O 095831 B-AWARD and O a O Royal B-ORG Society I-ORG Newton O International O Fellowship O NF140517 O T.M O by O the O National B-ORG Science I-ORG Foundation I-ORG NSF O CAREER O CCF-1452795 B-AWARD and O CCF-1319469 B-AWARD grants O and O G.E.D O by O the O Eck O Institute O for O Global O Health O and O the O NIGMS O R01-GM087508 O This O project O was O supported O by O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH O grant O R24-GM078274 O to O M.E.P O The O funding O bodies O did O not O have O a O role O in O the O design O of O the O study O data O collection O analysis O interpretation O of O data O writing O the O manuscript O nor O the O decision O to O publish O The O present O study O is O supported O by O the O National B-ORG Parasitic I-ORG Resources I-ORG Center I-ORG NPRC-2019-194-30 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31560179 B-AWARD No. O 21866020 B-AWARD the O Nanchang B-ORG University I-ORG College I-ORG Students’ I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Training I-ORG Program I-ORG No. O 2018388 B-AWARD and O Nanchang B-ORG University’s I-ORG Scientific I-ORG Research I-ORG Training I-ORG Program I-ORG 20190402197 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 81470788 B-AWARD 81770511 O the O Project B-ORG of I-ORG Key I-ORG Laboratory I-ORG of I-ORG the I-ORG Education I-ORG Department I-ORG of I-ORG Liaoning I-ORG grant O no. O LS201601 B-AWARD and O the O Outstanding B-ORG Scientific I-ORG Fund I-ORG of I-ORG Shengjing I-ORG Hospital I-ORG grant O no. O 201502 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Russian B-ORG Foundation I-ORG for I-ORG Basic I-ORG Research I-ORG grant O no.15-04-01857 O 16-34-00714 B-AWARD Russian B-ORG Science I-ORG Foundation I-ORG grant O no.15-15-20026 O and O the O granting B-AWARD program I-AWARD for I-AWARD “Molecular I-AWARD and I-AWARD Cell I-AWARD Biology” I-AWARD of O the O Russian B-ORG Academy I-ORG of I-ORG Sciences O Editing O and O publishing O costs O have O been O paid O for O by O a O grant O from O the O Russian O Science O Foundation O grant O no.15-15-20026 O This O study O was O supported O by O the O Alexander O von O Humboldt O Fellowship O a O grant O from O the O Russian B-ORG Foundation I-ORG for I-ORG Basic I-ORG Research I-ORG № O 19-58-55001 B-AWARD a O grant O from O the O Deutsche B-ORG Forschungsgemeinschaft I-ORG DFG O SFB824/3 B-AWARD BMBF B-ORG 01GU0823 O 02NUK038A B-AWARD BMWi O AiF O project O Germany O and O the O Technische O Universität O München O TUM O within O the O DFG O funding O programme O Open O Access O Publishing O Zsolt O Balogi O was O funded O by O UP O MS O KA-2018-05 O Huile O Gao O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81961138009).László O Vígh O was O funded O by O the O GINOP-2.3.2-15-2016-00060 O grant O This O study O was O funded O by O the O Fondo B-ORG de I-ORG Investigaciones I-ORG Sanitarias I-ORG Instituto I-ORG Carlos I-ORG III I-ORG Fondo I-ORG Europeo I-ORG de I-ORG Desarrollo I-ORG Regional I-ORG FEDER I-ORG PI O 080012 O PI B-AWARD 1100625 O to O JN O and O Grup B-ORG de I-ORG Suport I-ORG a I-ORG la I-ORG Recerca I-ORG of I-ORG the I-ORG Generalitat I-ORG de I-ORG Catalunya I-ORG 2014SGR0903 O to O JB. O This O research O was O supported O jointly O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41501308 O 41201238 O Chinese B-ORG National I-ORG Key I-ORG Basic I-ORG Research I-ORG Special I-ORG Funds I-ORG 2015BAD23B04 O and O Chinese B-ORG Special I-ORG Fund I-ORG for I-ORG Agro-scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG 201303104 O 201503124 O Research B-ORG Fund I-ORG for I-ORG the I-ORG Doctoral I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG of I-ORG China I-ORG 20120204120012 O This O work O was O supported O by O the O Tianjin B-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG Grant I-ORG 2017057 O to O Chunze O Zhang O the O Open B-ORG Research I-ORG Foundation I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Medicinal I-ORG Chemical I-ORG Biology I-ORG NanKai I-ORG University I-ORG 2018094 O to O Chunze O Zhang O the B-ORG Key I-ORG Technologies I-ORG R I-ORG I-ORG D I-ORG Program I-ORG of I-ORG Tianjin I-ORG Grant O 19YFZCSY00420 B-AWARD to O Chunze O Zhang O and O 18JCYBJC28100 B-AWARD to O Xichuan O Li O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O 81872236 B-AWARD to O Xichuan O Li O and O the O Foundation B-ORG of I-ORG Tianjin I-ORG Medical I-ORG University I-ORG Cancer I-ORG Institute I-ORG and I-ORG Hospital I-ORG 1707 O to O Jie O Zhang O This O work O was O supported O by O the O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG NIHR O Oxford O Biomedical O Research O Centre O grant O BRC-1215-20008 B-AWARD to O the O Oxford O University O Hospitals O NHS O Foundation O Trust O and O the O University O of O Oxford O The O views O expressed O are O those O of O the O author(s O and O not O necessarily O those O of O the O NHS O the O NIHR O or O the O Department O of O Health O and O Social O Care O Professor O Savulescu’s O work O supported O by O Wellcome B-ORG Trust I-ORG Grant O WT203132/Z/16/Z B-AWARD through O his O involvement O with O the O Murdoch O Children’s O Research O Institute O received O funding O from O the O Victorian O State O Government O through O the O Operational O Infrastructure O Support O OIS O Program O The O Wellcome B-ORG Centre I-ORG for O Ethics O and O Humanities O is O supported O by O a O Wellcome O Centre O Grant O 203132/Z/16/Z O This O work O was O supported O by O the O support O project O for O the O Disciplinary O group O of O Psychology O and O Neuroscience O Xinxiang O Medical O University O this O work O was O supported O by O grants O from O the O Medical B-ORG Technology I-ORG Foundation I-ORG of I-ORG Henan I-ORG Province I-ORG Grant O Numbers O 142300410025 B-AWARD 112102310211 B-AWARD Scientific B-ORG Research I-ORG Fund I-ORG of I-ORG Xinxiang I-ORG Medical I-ORG University I-ORG Grant O Number O 2013ZD117 B-AWARD and O Ministry B-ORG of I-ORG Health I-ORG research I-ORG fund I-ORG projects I-ORG in I-ORG China I-ORG Grant O Number O 20090103 B-AWARD Henan B-ORG Provincial I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Project I-ORG Grant O Number O 102101310400 B-AWARD This O work O was O supported O by O the O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG CIHR O RNL-132178 O to O GZ) O http://webapps O cihr-irsc.gc.ca/cfdd/db_search O Science B-ORG and I-ORG Technology I-ORG Development I-ORG Plan I-ORG of I-ORG Jilin I-ORG Province I-ORG 20180101302JC O to O WZ O Youth B-ORG technology I-ORG backbone I-ORG training I-ORG program I-ORG of I-ORG Health I-ORG department I-ORG of I-ORG Jilin I-ORG Province I-ORG 2017Q020 O to O WZ O China O Canadian O Institutes O of O Health O Research O CIHR O operating O grant O MOP192552 B-AWARD to O GS O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O research O was O supported O by O grants O from O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Council I-ORG 110-2314-B-182-057-MY3 O 110-2314-B-182A-076-MY3 B-AWARD National B-ORG Health I-ORG Research I-ORG Institutes I-ORG NHRI-EX111-11022NI O and O the O Chang B-ORG Gung I-ORG Medical I-ORG Foundation I-ORG Grant I-ORG CMRP8L1331 O CMRPG8M1091 B-AWARD CIRPG8M0091 B-AWARD to O M.-H.T O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 71473104 O the B-ORG Major I-ORG Program I-ORG of I-ORG the I-ORG National I-ORG Social I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 18ZDA081 O the O China O Centre O for O Economic O Development O and O Innovation O Strategy O Research O founded O by O Jinan O University O the B-ORG Humanities I-ORG and I-ORG Social I-ORG Research I-ORG Project I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG 18YJC790207 O This O study O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 41662024 B-AWARD and O U20A20267 B-AWARD Key B-ORG project I-ORG of I-ORG Jiangxi I-ORG Provincial I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG Grant O Nos O 20212BBG71011 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG China I-ORG 20202ACBL213006 O This O work O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51877046 B-AWARD Jihua B-ORG Laboratory I-ORG Projects I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 18002U100 B-AWARD and O Pioneering B-ORG Project I-ORG of I-ORG Academy I-ORG for I-ORG Engineering I-ORG and I-ORG Technology I-ORG of I-ORG Fudan I-ORG University I-ORG No. O gyy2018-002 B-AWARD This O research O was O funded O by O the O National B-ORG Science I-ORG Foundation I-ORG Grant O No. O 1356857 B-AWARD the O Center B-ORG for I-ORG Retirement I-ORG Research I-ORG project O BC14-D3 B-AWARD pursuant O to O a O grant O from O the O U.S O Social O Security O Administration O and O by O the O National B-ORG Institute I-ORG on I-ORG Aging I-ORG T32 O AG000221 O P30 B-AWARD AG012846 O K99 B-AWARD AG056599 O All O findings O and O conclusions O are O those O of O the O authors O and O do O not O represent O the O views O of O the O National O Science O Foundation O the O Social O Security O Administration O the O Center O for O Retirement O Research O or O the O National O Institute O on O Aging O This O study O is O covered O by O University O of O Michigan O IRB O approval O HUM00109579 O Restricted O data O from O the O Health O and O Retirement O Study O was O received O under O contract O 2015-031 O The O Health O and O Retirement O Study O HRS O is O sponsored O by O the O National O Institute O on O Aging O grant O number O NIA O U01AG009740 O and O the O Social O Security O Administration O and O conducted O by O the O University O of O Michigan O UM) O under O UM O Health O Sciences O IRB O Protocols O HUM00056464 O HUM00061128 O and O HUM00002562 O This O work O was O supported O by O the B-ORG Science I-ORG and I-ORG Technology I-ORG Infrastructure I-ORG Construction I-ORG Program I-ORG of I-ORG Fujian I-ORG Province I-ORG grant O no. O 2014Y2005 B-AWARD the B-ORG Youth I-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG Fujian I-ORG Provincial I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG grant O no. O 2017-1-85 B-AWARD the B-ORG Startup I-ORG Fund I-ORG for I-ORG scientific I-ORG research I-ORG Fujian I-ORG Medical I-ORG University I-ORG grant O no. O 2016QH081 B-AWARD the B-ORG Scientific I-ORG Innovation I-ORG Project I-ORG of I-ORG Fujian I-ORG Provincial I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG grant O no. O 2014-CXB-24 B-AWARD the B-ORG Project I-ORG of I-ORG Fuzhou I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG grant O no. O 2016-s-124-9 B-AWARD and O 2016-s-124-4 B-AWARD and O the B-ORG Scientific I-ORG Foundation I-ORG of I-ORG Fuzhou I-ORG Health I-ORG Department I-ORG grant O no. O 2015-S-wq13 B-AWARD Carlos O N. O Ibarra-Cerdeña O CNIC O was O funded O with O a O graduate O scholarship O from O CONACYT O Consejo O Nacional O de O Ciencia O y O Tecnología O for O his O PhD O studies O in O the O Biomedical O Sciences O Program O of O the O UNAM O Universidad O Nacional O Autónoma O de O Mexico O fulfilled O in O part O by O this O study O Janine O Ramsey O was O funded O by O CONACyT B-ORG FONSEC I-ORG 161405 B-AWARD and O CONACyT B-ORG SEP I-ORG 166828 B-AWARD Víctor O Sánchez-Cordero O was O funded O by O PAPIIT-UNAM B-ORG IN209314 B-AWARD Christopher O R. O Stephens O was O funded O by O PAPIIT-UNAM O IN113414 B-AWARD y O CONACyT B-ORG Fronteras I-ORG grant O FC-2015-2/1093 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Breast O Cancer O Research O Program O Breakthrough O Award O BC141727 B-AWARD from O the O Department B-ORG of I-ORG Defense I-ORG https://cdmrp.army.mil O R00 O Pathway O to O Independence O award O ES022633 B-AWARD from O the O National B-ORG Institute I-ORG of I-ORG Environmental I-ORG Health I-ORG Sciences I-ORG https://www.niehs.nih.gov O and O R01 O award O CA218112 B-AWARD from O the O National B-ORG Cancer I-ORG Institute I-ORG https://www.cancer.gov O to O S.A.R O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Science-Technology B-ORG Project I-ORG of I-ORG Henan I-ORG province I-ORG 172102110244 O Central B-ORG Public-Interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG 1610192017709 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31272140 O and O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG ASTIP O CAAS-ASTIP O This O study O was O supported O by O research O funding O from O FEDER B-ORG funds O CIBERONC O CB16/12/00284 O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III I-ORG ISCIII O grants O PI18/1472 B-AWARD PI19/00812 B-AWARD and O PI22/01633 B-AWARD Fundació B-ORG La I-ORG Marató I-ORG de I-ORG TV3 I-ORG grant O 228/C/2020 B-AWARD as O well O as O from O the O Conselleria B-ORG de I-ORG Educación I-ORG Cultura I-ORG y I-ORG Deporte I-ORG CIGE/2021/015 B-AWARD M.S O is O the O recipient O of O the O “Clinico O Junior O 2019” O CLJUN19005SANT O and O Rio B-ORG Hortega I-ORG CM22/00191 O fellowships O granted O by O the O Asociación B-ORG Española I-ORG contra I-ORG el I-ORG Cáncer I-ORG AECC O and O the O ISCIII O respectively O A.L O is O the O recipient O of O the O APOSTD/2021/212 B-AWARD Generalitat B-ORG Valenciana I-ORG post-doctoral O fellowship O This O work O was O supported O by O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81200576 B-AWARD Wenzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG grant O number O Y20170047 B-AWARD National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG grant O number:2016YFC1305202 O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG grant O number O LQ12H07003 B-AWARD Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O LY14H070007 B-AWARD This O research O was O supported O by O the O Research B-ORG and I-ORG Innovation I-ORG Projects I-ORG of I-ORG ZhongNan I-ORG University I-ORG of I-ORG Economics I-ORG and I-ORG Law I-ORG grant O No.202310307 B-AWARD Youth B-ORG Project I-ORG of I-ORG Gansu I-ORG Natural I-ORG Science I-ORG Foundation I-ORG 22JR5RA542 O General B-ORG Project I-ORG of I-ORG Gansu I-ORG Philosophy I-ORG and I-ORG Social I-ORG Science I-ORG Foundation I-ORG 2022YB014 O Lanzhou B-ORG Philosophy I-ORG and I-ORG Social I-ORG Science I-ORG Planning I-ORG Project I-ORG 22-A42 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 72034003 O 72243006 B-AWARD 71874074 B-AWARD and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG lzujbky-2021-sp72 O This O research O was O funded O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG of I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG the I-ORG People’s I-ORG Republic I-ORG of I-ORG China I-ORG 2022YFC2409700 O and O 2022YFC2401804 B-AWARD the O Key-Area B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2020B0101020001 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31971318 O 81973001 B-AWARD and O 22027810 B-AWARD This O research O was O funded O by O the O following O Spanish O institutions O the O Ministry B-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG MICYT O Grant O MAT2002-01831 B-AWARD the O Ministry B-ORG for I-ORG Education I-ORG and I-ORG Science I-ORG MEC O Grant O BIA2005-08965 B-AWARD the O Ministry B-ORG for I-ORG Science I-ORG and I-ORG Innovation I-ORG MICINN O Grant O BIA2008-06810 B-AWARD the O Ministry B-ORG for I-ORG Economy I-ORG and I-ORG Competitiveness I-ORG MINECO O Grant O BIA2011-27870 B-AWARD and O Junta B-ORG de I-ORG Castilla I-ORG y I-ORG León I-ORG JCyL O Grants O SA067A05 B-AWARD SA111A07 B-AWARD SA039A08 B-AWARD and O SA132G18 B-AWARD This O work O was O supported O by O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81471881 O 81772101 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG of I-ORG China I-ORG 2017A030313900 O and O President B-ORG Foundation I-ORG of I-ORG Nanfang I-ORG Hospital I-ORG 2016Z010 O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2016YFD0101802 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 3181101544 O and O Henan B-ORG Major I-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG 181100110200 O of O China O The O supporters O did O not O play O any O role O in O the O design O analysis O or O interpretation O of O this O study O and O the O relevant O data O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. B-AWARD 81400756 I-AWARD and I-AWARD No. I-AWARD 81202022 O the B-ORG Public I-ORG Welfare I-ORG Technology I-ORG project I-ORG of I-ORG Science I-ORG Technology I-ORG Department I-ORG of I-ORG Zhejiang I-ORG Province I-ORG Grant O No. O 2014C33184 B-AWARD Zhejiang B-ORG health I-ORG Bureau I-ORG Grant O No. O 2016KYA093 B-AWARD and O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O LY16H160028 B-AWARD The O research O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0300209 O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG 31571615 O and O the O Program B-ORG on I-ORG Industrial I-ORG Technology I-ORG System I-ORG of I-ORG National I-ORG Soybean I-ORG CARS-04-PS19 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O Beijing B-ORG Municipal I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Beijing I-ORG Municipal I-ORG Education I-ORG Commission I-ORG Science I-ORG I-ORG Technology I-ORG Plan I-ORG Key I-ORG Joint I-ORG Project O grant O number O KZ202010011016 B-AWARD Beijing B-ORG Engineering I-ORG Technology I-ORG Research I-ORG Center I-ORG Platform I-ORG Construction I-ORG Project O grant O number O 19008022080 B-AWARD The B-ORG Construction I-ORG of I-ORG High-precision I-ORG Disciplines I-ORG in I-ORG Beijing-Food I-ORG Science I-ORG I-ORG Engineering O grant O number O 19008021085 B-AWARD and O Cultivation B-ORG Project I-ORG of I-ORG Double I-ORG First-Class I-ORG Disciplines I-ORG of I-ORG Food I-ORG Science I-ORG and I-ORG Engineering I-ORG Beijing I-ORG Technology I-ORG I-ORG Business I-ORG University O grant O number O BTBUYXTD202208 B-AWARD This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31671837 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG China I-ORG No. O 20224ACB205011 O and O the O Training B-ORG Plan I-ORG for I-ORG the I-ORG Main I-ORG Subject I-ORG of I-ORG Academic I-ORG Leaders I-ORG of I-ORG Jiangxi I-ORG Province I-ORG No. O 20172BCB22006 O This O study O was O partially O sponsored O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 81761148029 O 81725009 B-AWARD 82030049 B-AWARD 82021002 B-AWARD 81971641 B-AWARD Ministry O of O Science O and O Technology O of O China O MOST O 2021YFA110004500 O 2021YFE0108300 O Clinical B-ORG Research I-ORG Plan I-ORG of I-ORG SHDC I-ORG SHDC2020CR1038B O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG 2030 I-ORG Major I-ORG Projects I-ORG 2022ZD0211600 O Swiss O National O Science O Foundation O project O nos O 185028 O 188355 O and O 169876 O and O National O Research O Foundation O of O Korea O NRF-2017K2A9A2A10013554 O VG O has O received O fundings O from O the O Velux O Foundation O the O Schmidheiny O Foundation O and O research/teaching O support O through O her O institution O from O Siemens O Healthineers O GE O Healthcare O Roche O Merck O Cerveau O Technologies O and O Life O Molecular O Imaging O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32160224 O 12132006 B-AWARD the O Guizhou B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG ZK[2022]349 O 2021-5637 B-AWARD ZK2021-029 B-AWARD ZK2022-397 B-AWARD the O Youth B-ORG Science I-ORG and I-ORG Technology I-ORG Talents I-ORG Growth I-ORG Project I-ORG of I-ORG Guizhou I-ORG Ordinary I-ORG Colleges I-ORG and I-ORG Universities I-ORG KY[2022]220 O the O Science B-ORG and I-ORG Technology I-ORG Fund I-ORG Project I-ORG of I-ORG Guizhou I-ORG Provincial I-ORG Health I-ORG Commission I-ORG gzwkj2022-228 O gzwkj2022-444 B-AWARD the O Excellent B-ORG Young I-ORG Talents I-ORG Plan I-ORG of I-ORG Guizhou I-ORG Medical I-ORG University I-ORG 2021-101 O the O Cultivation B-ORG Project I-ORG for I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21NSFCP38 O the O High-Level B-ORG Talent I-ORG Initiation I-ORG Project I-ORG of I-ORG Guizhou I-ORG Medical I-ORG University I-ORG J[2021 O 029 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 81571273 B-AWARD 81571274 B-AWARD and O 81501125 B-AWARD Omics-based B-ORG precision I-ORG medicine I-ORG of I-ORG epilepsy I-ORG being I-ORG entrusted I-ORG by I-ORG Key I-ORG Research I-ORG Project I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG Grant O No. O 2016YFC0904400 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG Grant O No. O 2014A030313489 B-AWARD and O Medical B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG Grant O No. O A2013268 B-AWARD The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG 2018-I2M-1-004 O the O Chinese B-ORG Medical I-ORG Association I-ORG clinical I-ORG medical I-ORG research I-ORG specific I-ORG fund I-ORG 18010310760 O the O National B-ORG “13th I-ORG Five-Year” I-ORG Plan I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG 2018YFC1003601 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 3332018187 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81803116 O and O Suzhou B-ORG Science I-ORG I-ORG Technology I-ORG Planning I-ORG Project I-ORG sys2018077 O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31601551 B-AWARD and O 31671931 B-AWARD Natural O Science O Foundation O of O Hunan O Province O No. O 2019J50240 O Scientific B-ORG Research I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Provincial I-ORG Education I-ORG Department I-ORG No. O 18B118 B-AWARD and O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2019M650187 B-AWARD This O work O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grants O No. O 61931011 I-AWARD No. I-AWARD 61872178 I-AWARD No. I-AWARD 61827801 I-AWARD No. I-AWARD 61702545 I-AWARD No. I-AWARD 61702525 I-AWARD and I-AWARD No. I-AWARD 61631020 O in O part O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. B-AWARD 021014380079 O and O in O part O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG under O Grant O No. B-AWARD BK20181251 I-AWARD 1. O Chao O F. O Grant O Number O 2019BS03009 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Inner I-ORG Mongolia,http://kjt.nmg.gov.cn/2 O Chao O F. O Grant O Number O NJZY19230 B-AWARD the O College B-ORG and I-ORG University I-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG Inner I-ORG Mongolia,http://jyt.nmg.gov.cn/3 O Chao O F. O Grant O Number O 2018JYYB16 B-AWARD the O Scientific B-ORG Research I-ORG Projects I-ORG of I-ORG Hulunbuir I-ORG University,http://www.hlbrc.cn/4 O Chao O F. O Grant O Number O 2018BS48 B-AWARD the O PhD B-ORG Foundation I-ORG Project I-ORG of I-ORG Hulunbuir I-ORG University,http://www.hlbrc.cn/The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Province B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG No. O 2017A030313200 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31400544 B-AWARD the O Distinguish B-ORG Young I-ORG Scientist I-ORG Starting I-ORG Grant I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2017KQNCX016 B-AWARD and O the O Innovation B-ORG and I-ORG Entrepreneurship I-ORG Training I-ORG Program I-ORG for I-ORG College I-ORG Students I-ORG of I-ORG South I-ORG China I-ORG Agricultural I-ORG University I-ORG No. O 201910564396 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O by O the O Joint B-ORG programme I-ORG of I-ORG the I-ORG Israel I-ORG Science I-ORG Foundation I-ORG and I-ORG the I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 2482/16 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31661143045 O International B-ORG Atomic I-ORG Energy I-ORG Agency I-ORG CRP O No. I-AWARD 17153 I-AWARD and I-AWARD No. I-AWARD 18269 O Agricultural B-ORG public I-ORG welfare I-ORG industry I-ORG research I-ORG supported O by O Ministry O of O Agriculture O of O People’s O Republic O of O China O 201503137 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2662015PY148 O This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O 81660131 B-AWARD to O Zhu O Yongjun O and O the B-ORG Hainan I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Hainan I-ORG Province O 20168301 B-AWARD to O Zhu O Yongjun O and O Science B-ORG and I-ORG Technology I-ORG Cooperation I-ORG Project I-ORG from I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Hainan I-ORG Province O ZDYF2019215 B-AWARD to O Zhu O Yongjun O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.32001648 O 32160538 B-AWARD and O the O Science B-ORG Funds I-ORG of I-ORG Shihezi I-ORG University I-ORG No. O CXPY201901 B-AWARD RCZK201919 B-AWARD ZZZC201911A B-AWARD CXBJ202108 B-AWARD Key B-ORG Laboratory I-ORG for I-ORG Nutrition I-ORG and I-ORG Safety I-ORG of I-ORG Xinjiang I-ORG Specialty I-ORG Foods I-ORG Shihezi I-ORG City I-ORG of I-ORG Eighth I-ORG Division I-ORG grant O number O 2022PT02 B-AWARD and O Innovative B-ORG team-building I-ORG plan I-ORG for I-ORG key I-ORG field I-ORG projects I-ORG in I-ORG Xinjiang I-ORG Production I-ORG and I-ORG Construction I-ORG Corps I-ORG grant O number O 2019CB007 B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundations I-ORG of I-ORG China I-ORG grant O No. O 81771632 B-AWARD and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG grant O No. O 2016YFC1000500 B-AWARD to O Qiang O Li; O by O the O National O Natural O Science O Foundations O of O China O grant O No. O 81470442 B-AWARD 81741081 B-AWARD 81873481 B-AWARD and O 81170147 B-AWARD 973 B-ORG Program I-ORG grant O No. O 2013CB945401 B-AWARD to O Yonghao O Gui O and O by O the O Shanghai B-ORG Key I-ORG Laboratory I-ORG of I-ORG Birth I-ORG Defects I-ORG grant O No. O 13DZ2260600 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Instituto B-ORG Politécnico I-ORG de I-ORG Lisboa I-ORG Lisbon I-ORG Portugal I-ORG for O funding O the O Project O “Resistance O modulation O and O epigenetic O divergence O in O resistant O phenotypic O profiles O ofStaphylococcus O aureus” O IPL/2020 O EpiResistanceSA I-AWARD ESTeSL O H&TRC O authors O gratefully O acknowledge O the O FCT/MCTES B-ORG national I-ORG support I-ORG through O the O UIDB/05608/2020 B-AWARD and O UIDP/05608/2020 B-AWARD This O work O was O also O supported O by O the O project O grant O DSAIPA/DS/0117/2020 B-AWARD from O FCT B-ORG Portugal I-ORG This O research O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2018YFD0500600 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31772637 B-AWARD and O Henan B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 162300410048 B-AWARD The O authors O acknowledge O that O this O work O was O supported O by O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2014CB542300 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81101330 O 31271378 B-AWARD 81250044 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK2012014 O and O the O Research O Special O Fund O for O Public B-ORG Welfare I-ORG Industry I-ORG of I-ORG Health I-ORG 201302018 O This O work O was O also O supported O by O the O Program B-ORG for I-ORG New I-ORG Century I-ORG Excellent I-ORG Talents I-ORG in I-ORG University I-ORG from O Ministry O of O Education O of O China O NCET-12-0261 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 81570127 B-AWARD O 81370638 B-AWARD O 81530046 B-AWARD the B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG of I-ORG China I-ORG 2016B030230003 O the B-ORG Foundation I-ORG for I-ORG Innovative I-ORG Research I-ORG Groups I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81621001 O Milstein O Medical O Asian O American O Partnership O MMAAP O Foundation O and O the O Beijing O Municipal O Science O and O Technology O Program O Z151100004015164 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O no. O 51974187 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province I-ORG Grant O no. O 2019-MS-242 B-AWARD and O Liaoning B-ORG Provincial I-ORG Education I-ORG Department I-ORG focusing I-ORG on I-ORG tackling I-ORG key I-ORG problems I-ORG Grant O no. O LZGD2020004 B-AWARD Funding O was O provided O by O the O Minnesota B-ORG Turkey I-ORG Research I-ORG and I-ORG Promotion I-ORG Council I-ORG award O 2013-01 B-AWARD University B-ORG of I-ORG Minnesota I-ORG MNDrive B-AWARD Initiative O University O of O Minnesota O Rapid B-AWARD Agricultural I-AWARD Response I-AWARD Funds O and O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG PharmacoNeuroImmunology O Fellowship O NIH/NIDA O T32 O DA007097-32 B-AWARD awarded O to O JC. O This O work O was O supported O by O the O Canadian B-ORG Poultry I-ORG Research I-ORG Council I-ORG http://cp-rc.ca O AMN088 B-AWARD received O by O MFA O the O Alberta B-ORG Agriculture I-ORG and I-ORG Forestry I-ORG http://www.agric.gov.ab.ca/app21/ministrypage O 2016R003R B-AWARD received O by O MFA O and O the O Natural B-ORG Sciences I-ORG and I-ORG Engineering I-ORG Research I-ORG Council I-ORG of I-ORG Canada I-ORG http://www.nserc-crsng.gc.ca/index_eng.asp O CRDPJ/491522-2015 B-AWARD received O by O MFA O This O work O was O supported O by O a O Key B-ORG Project I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O Grant O ID: O 8177060452 B-AWARD This O work O was O supported O by O Key B-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Sichuan I-ORG Province O Grant O ID: O 2017SZ0067 B-AWARD and O 1.3.5 B-ORG project I-ORG for I-ORG disciplines I-ORG of I-ORG excellence O West O China O Hospital O Sichuan O University O Grant O ID: O ZY2016104 B-AWARD The O funding O bodies O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O The O present O study O was O supported O by O the O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81673181 O 81703244 B-AWARD Guangzhou B-ORG Science I-ORG Technology I-ORG and I-ORG Innovation I-ORG Commission I-ORG 201508030037 O and O Guangdong B-ORG Provincial I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2014A020213022 O This O work O was O supported O by O the O National B-ORG Aeronautics I-ORG and I-ORG Space I-ORG Administration I-ORG NASA O grant O number O NNL15AA16C B-AWARD Air B-ORG Force I-ORG Office I-ORG of I-ORG Scientific I-ORG Research I-ORG AFOSR O grant O number O FA9550-16-1-0401 B-AWARD US B-ORG Department I-ORG of I-ORG Energy I-ORG DOE O grant O number O DE-NE B-AWARD 0000726 O Office O of O Nuclear O Energy O ONE O grant O number O DE-NE O 0008400 O and O Office O of O Naval O Research O ONR O grant O number O N00014-17-1-2829 O This O work O was O supported O by O grants O from O the O Spanish B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Innovation I-ORG MICINN O the O Carlos B-ORG III I-ORG Health I-ORG Institute/European I-ORG Regional I-ORG Development I-ORG Fund I-ORG ERDF O MICINN O ISCIII/FEDER O Red O RedIAPP B-AWARD RD06/0018 O Research O Groups O RD16/0007/0003 O RD16/0007/0004 O RD16/0007/0008 O the O Health O Research O Fund O PI10/01088 O PI10/02077 I-AWARD PI10/02043 O PI13/01930 B-AWARD and O the O Regional B-ORG Health I-ORG Management I-ORG of I-ORG Castile I-ORG and I-ORG León I-ORG GRS O 635/A/11 O GRS B-AWARD 906/B/14 O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61107055 O the B-ORG Specialized I-ORG Research I-ORG Fund I-ORG for I-ORG the I-ORG Doctoral I-ORG Program I-ORG of I-ORG Jiangsu I-ORG University I-ORG of I-ORG Technology I-ORG KYY17011 O and O the B-ORG Jiangsu I-ORG Province I-ORG Key I-ORG Laboratory I-ORG of I-ORG Materials I-ORG Surface I-ORG Science I-ORG and I-ORG Technology I-ORG KFBM20170003 O This O work O was O supported O by O a O British B-ORG Heart I-ORG Foundation I-ORG programme I-ORG grant O PG/18/4/33541 O to O J.A.M O and O N.S.K O a O British B-ORG Heart I-ORG Foundation I-ORG Intermediate I-ORG Basic I-ORG Science I-ORG Research I-ORG Fellowship I-ORG FS/16/1/31699 O to O N.S.K O an O Imperial B-ORG College I-ORG Junior I-ORG Research I-ORG Fellowship I-ORG PS2129 O to O N.S.K O a O Royal B-ORG Society I-ORG Research I-ORG Grant O RG150248 O to O N.S.K O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81470572 O to O Y.Z O and O 81370384 B-AWARD to O B.L O the O Intramural B-ORG Program I-ORG of I-ORG the I-ORG NIH I-ORG National I-ORG Institute I-ORG of I-ORG Environmental I-ORG Health I-ORG Sciences I-ORG Z01 O ES025034 I-AWARD to O D.C.Z O a O grant O from O the O Singapore B-ORG Ministry I-ORG of I-ORG Education I-ORG under I-ORG its I-ORG Singapore I-ORG Ministry I-ORG of I-ORG Education I-ORG Academic I-ORG Research I-ORG Fund I-ORG Tier I-ORG 2 I-ORG to O X.W O and O W.W O MOE2014-T2-1-036 B-AWARD and O Start-Up O grants O from O the O Lee O Kong O Chian O School O of O Medicine O Nanyang O Technological O University O to O X.W O and O W.W O Swedish B-ORG Research I-ORG Council I-ORG 2017-02577 O to O P-J.J O Innovative B-ORG Medicines I-ORG Initiative I-ORG EU/EFPIA O ULTRA-DD O 115766 B-AWARD to O P-J.J O Stockholm B-ORG County I-ORG Council I-ORG ALF O 20160378 B-AWARD to O P-J.J O the O Swedish B-ORG Rheumatism I-ORG Association I-ORG R-755861 O to O P-J.J O King O Gustaf O V’s O 80-year O foundation O to O P-J.J O Funds O from O Karolinska O Institutet O to O P-J.J O Cancerfonden O to O P-J.J O Radiumhemmets O forskningsfonde O to O P-J.J O The O research O has O been O funded O by O the O European B-ORG Research I-ORG Council I-ORG ERC O under O the O European O Community’s O Horizon O 2020 O Program O ERC O grant O 81995 B-AWARD K.T.-R O the O Distinguished O Professorship O program O of O the O Helmholtz O Society O K.T.-R O the O University O of O Vienna O research O platforms O Rhythms O of O Life O F.R O and O K.T.-R O and O Single-Cell O Regulation O of O Stem O Cells O F.R O Austrian B-ORG Science I-ORG Fund I-ORG Fonds O zur O Förderung O der O Wissenschaftlichen O Forschung O FWF O projects O I2972 B-AWARD F.R O and O SFB B-AWARD F78 I-AWARD F.R O and O K.T.-R O A.W.S O is O a O recipient O of O a O DOC O Fellowship O of O the O Austrian B-ORG Academy I-ORG of I-ORG Sciences I-ORG at O the O Max O Perutz O Labs O The O work O was O supported O by O The B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC1101605 O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81190133 O and O 51172171 O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG 2015CFB551 O the O Key O Technology O Research O and O Development O Program O of O Hubei O province O 2015BAA085 O and O the O Science O and O Technology O Project O of O Wuhan O 2015060101010032 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 51771119 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG Grant O No. O 17ZR1419600 B-AWARD and O Shanghai B-ORG Engineering I-ORG Technology I-ORG Research I-ORG Center I-ORG of I-ORG High-Performance I-ORG Medical I-ORG Device I-ORG Materials I-ORG No. O 20DZ2255500 B-AWARD This O research O was O supported O by O grants O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81571658 B-AWARD and O 81201082 B-AWARD to O X. O X. O Du O the O National O Natural O Science O Foundation O of O China O No. O 81271302 B-AWARD to O J. O R. O Liu O the B-ORG Research I-ORG Innovation I-ORG Project I-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG No. O 14JC1404300 B-AWARD to O J. O R. O Liu O and O the B-ORG Open I-ORG Fund I-ORG of I-ORG the I-ORG National I-ORG Key I-ORG Laboratory I-ORG of I-ORG Medical I-ORG and I-ORG Neurobiology I-ORG of I-ORG Fudan I-ORG University I-ORG No. O SKLMN2014001 B-AWARD to O J. O R. O Liu O by O a O project O 2015 O from O SHSMU-ION O Research O Center O for O Brain O Disorders O to O J. O R. O Liu O by O the B-ORG Clinical I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG Shanghai I-ORG ShenKang I-ORG Hospital I-ORG Development I-ORG Center I-ORG No. O SHDC12015310 B-AWARD to O J. O R. O Liu O and O by O a B-ORG biomedicine I-ORG key I-ORG project I-ORG from I-ORG Shanghai I-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG No. O 16411953100 B-AWARD to O J.R O Liu O This O research O was O funded O by O National O Key O R&D O Program O of O China O 2018YFD0501800 O Key O Technology O R&D O Program O of O Ningxia O 2017BY078 O O 2018BFF02001 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31802084 O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-37 O and O Chinese B-ORG Universities I-ORG Scientific I-ORG Fund I-ORG 2019TC001 O I-AWARD 2019TC156 O The O APC O was O funded O by O the O same O funds O described O above O This O work O was O supported O by O the O grants O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No.2016YFC1101400 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81570976 B-AWARD and I-AWARD 81870768 O the O Scientific B-ORG Young I-ORG Alma I-ORG of I-ORG Shaanxi I-ORG province I-ORG 2018KJXX-015 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81272139 O and O the O Zhejiang B-ORG Provincial I-ORG Program I-ORG for I-ORG the I-ORG Cultivation I-ORG of I-ORG High-level I-ORG Innovative I-ORG Health I-ORG Talents I-ORG 2016-6 O to O QS; O and O the O National O Natural O Science O Foundation O of O China O 81270068 O and O 81570071 B-AWARD Zhejiang B-ORG Health I-ORG Bureau I-ORG Cultivation I-ORG Plan I-ORG 2014PYA020 O and O Zhejiang B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG 2015C33256 O to O JX. O The O authors O are O grateful O for O the O financial O support O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 52278236 O 52172013 B-AWARD the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Projects I-ORG in I-ORG Anhui I-ORG Province I-ORG 202004b11020033 O 202104a07020018 B-AWARD the O Cultivation B-ORG Project I-ORG of I-ORG Scientific I-ORG Research I-ORG Reserve I-ORG of I-ORG Anhui I-ORG Jianzhu I-ORG University I-ORG 2021XMK02 O and O the O Excellent B-ORG Scientific I-ORG Research I-ORG and I-ORG Innovation I-ORG Team I-ORG of I-ORG Universities I-ORG in I-ORG Anhui I-ORG Province I-ORG 2022AH010017 O This O research O was O supported O by O grants O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0500800 O the O China B-ORG Agricultural I-ORG Research I-ORG System I-ORG CARS-42-17 O the O Special B-ORG Fund I-ORG for I-ORG Key I-ORG Laboratory I-ORG of I-ORG Animal I-ORG Disease I-ORG and I-ORG Human I-ORG Health I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2016JPT0004 O and O the O International B-ORG S&T I-ORG Cooperation I-ORG Program I-ORG of I-ORG Sichuan I-ORG Province I-ORG Grant O No. O 2017HH0026 B-AWARD This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20161110 O to O Quan’an O Zhang O the O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O JX10231802 B-AWARD to O Jinyan O Wang O Postgraduate O Research O and O Practice B-ORG Innovation I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG SJCX17_0387 O to O Jinyan O Wang O the O Science B-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Health I-ORG vocational I-ORG college I-ORG JKC201948 O to O Jinyan O Wang O and O the O Science B-ORG and I-ORG Technology I-ORG Development I-ORG Fund I-ORG of I-ORG Nanjing I-ORG Medical I-ORG University I-ORG NMUB2019235 O to O Jinyan O Wang O Nanjing B-ORG health I-ORG science I-ORG and I-ORG Technology I-ORG Development I-ORG Fund I-ORG YKK18201 O to O Yan O Yang O Science O and O technology O development O fund O of O Nanjing O Medical O University O 2017NJMUZD091 O to O Yan O Yang O and O the O Research O and O development O fund O of O Kangda B-ORG College I-ORG of I-ORG Nanjing I-ORG Medical I-ORG University I-ORG KD2017KYJJYB017 O to O Yan O Yang O This O research O was O funded O by O the O Engineering B-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG UK) O IAA O Impact I-AWARD Support I-AWARD Fund I-AWARD Award I-AWARD via O University O of O Manchester O the O Swiss B-ORG Agency I-ORG for I-ORG Development I-ORG and I-ORG Cooperation I-ORG project O no. O 7F-09963.01.01 B-AWARD the O Natural O Environmental O Research O Council O UK) O NE/R003386/1 O and O DST B-ORG India O DST/TM/INDO-UK/2K17/55(C O I-AWARD 55(G O This O study O was O funded O by O the O “13th O Five-Year” O plan O for O the O development O of O philosophy O and O social O sciences O in O Guangzhou O 2018GZGJ67 O from O the O Guangzhou B-ORG Association I-ORG of I-ORG Social I-ORG Science I-ORG Societies I-ORG http://www.gzsk.org.cn O the O Special O Funds O for O Provincial O Health O and O Family O Planning O Development O of O Guangdong O in O China O in O 2016 O AIDS O prevention O project O 2100409 B-AWARD from O Department B-ORG of I-ORG Finance I-ORG of I-ORG Guangdong I-ORG Province I-ORG http://czt.gd.gov.cn O and O the O Young B-ORG Scientists I-ORG Fund I-ORG 81703282 O from O the O National O Natural O Science O Foundation O of O China O http://www.nsfc.gov.cn O The O funding O bodies O had O no O role O of O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O writing O of O the O manuscript O This O study O was O funded O by O Singapore B-ORG Institute I-ORG of I-ORG Technology I-ORG Ignition O Grant O R-MOE-E103-F019 O and O ACP O was O funded O by O Singapore B-ORG Food I-ORG Story I-ORG Theme I-ORG 2—1st O Alternative O Protein O Seed O Challenge O Grant O W20W2D0013 O and O W20W2D0019 B-AWARD and O Singapore B-ORG Food I-ORG Story I-ORG R&D I-ORG Programme I-ORG Industry I-ORG Alignment I-ORG Fund I-ORG Pre-positioning I-ORG IAF-PP I-ORG Theme I-ORG 2—Advanced O Biotech-based O Protein O Production O Grant O A21H7a0131 O and O H21H8a0005 B-AWARD This O work O was O supported O in O part O by O the O Liaoning O Provincial O Natural O Science O Foundation O of O China O under O Grant O 2020-MS-031 O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O 61821005,51809256 B-AWARD in O part O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG under O Grant O No. O 2016YFC0300801 B-AWARD 2016YFC0301601 I-AWARD 2016YFC0300604 I-AWARD 2017YFC1405401 O in O part O by O the O Strategic O Priority O Research O Program O of O the O Chinese O Academy O of O Sciences O under O Grant O No. O XDA13030203 O in O part O by O the O Instrument O Developing O Project O of O the O Chinese O Academy O of O Sciences O under O Grant O No. O YZ201441 O in O part O by O the O LiaoNing O Revitalization O Talents O Program O under O Grant O No. O XLYC1902032 O in O part O by O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG under O Grant O No. O 2019M662874 B-AWARD and O in O part O by O the O State O Key O Laboratory O of O Robotics O at O Shenyang O Institute O of O Automation O under O Grant O 2017-Z13 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31660584 B-AWARD and O No. O 31260473 B-AWARD the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-23-C-07 O and O the O Major B-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG Fund I-ORG of I-ORG Gansu I-ORG Province I-ORG No. O 17ZD2NA015 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O is O supported O by O a O grant O from O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 61402326 B-AWARD Peiyang B-ORG Scholar I-ORG Program I-ORG of I-ORG Tianjin I-ORG University I-ORG no. O 2016XRG-0009 B-AWARD and O the O Tianjin B-ORG Research I-ORG Program I-ORG of I-ORG Application I-ORG Foundation I-ORG and I-ORG Advanced I-ORG Technology I-ORG 16JCQNJC00200 O Financial O support O was O received O from O the O Cochrane B-ORG Methods I-ORG Innovation I-ORG Funds I-ORG Round I-ORG 2 I-ORG MTH001F O and O Cochrane B-ORG Trusted I-ORG methods I-ORG and I-ORG Support I-ORG for I-ORG Cochrane I-ORG Reviews I-ORG of I-ORG Prognostic I-ORG studies O KGMM O received O a O grant O from O the O Netherlands B-ORG Organization I-ORG for I-ORG Scientific I-ORG Research I-ORG ZONMW O 918.10.615 B-AWARD and O 91208004 B-AWARD and O from O the O CREW B-ORG NHS I-ORG project O grant O number O 2013T083 B-AWARD co-funded O by O the O Dutch O Heart O Society O TPAD O was O supported O by O the O Netherlands O Organization O for O Scientific O Research O 91617050 O This O research O was O funded O by O the O Foundation B-ORG for I-ORG Research I-ORG and I-ORG Innovation I-ORG Support I-ORG of I-ORG Espírito I-ORG Santo I-ORG FAPES O grant O number O 917/2022 B-AWARD the O National B-ORG Council I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Development I-ORG CNPq O grant O number O 309535/2021-2 B-AWARD and O the O Brazilian B-ORG Federal I-ORG Agency I-ORG for I-ORG Support I-ORG and I-ORG Evaluation I-ORG of I-ORG Graduate I-ORG Education I-ORG CAPES O finance O code O 001 B-AWARD This O project O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 21675071 B-AWARD and O 31701827 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG Mayor I-ORG China O ZR2017CM009 B-AWARD and O the O Shandong B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Plan I-ORG J12LE07 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31772321 O the O Beijing B-ORG Municipal I-ORG National I-ORG Science I-ORG Foundation I-ORG KZ201610020019 O and O the B-ORG Scientific I-ORG Research I-ORG Quality I-ORG Improvement I-ORG Funds I-ORG of I-ORG Beijing I-ORG University I-ORG of I-ORG Agriculture I-ORG YQ201604 O and O Earmarked O Fund O for O Beijing O Leaf O Vegetables O Innovation O Team O of O Modern O Agro-industry O Technology O Research O System O BLVT-21 O This O work O was O supported O in O part O by O the O National O Research O Foundation O of O Korea O NRF O grant O funded O by O the B-ORG Korea I-ORG Government I-ORG MSIT O No. O 2021R1F1A1064358 B-AWARD and O in O part O by O the O Institute O of O Information O and O Communications O Technology O Planning O and O Evaluation O IITP O grant O funded O by O the O Korean B-ORG government I-ORG MSIT O No. O 2021-0-02087 B-AWARD Application O Techniques O of O the O 3D O Semantic O Scene O Reconfiguration O for O Social O Interaction-based O Multi-Robot O Autonomous O Navigation O and O in O part O by O the O Government-wide O R&D O Fund O for O Infections O Disease O Research O GFID O funded O by O the O Ministry B-ORG of I-ORG the I-ORG Interior I-ORG and I-ORG Safety I-ORG Republic I-ORG of I-ORG Korea I-ORG grant O number O 20014854 B-AWARD This O analysis O received O no O specific O grant O from O any O funding O agency O commercial O or O not-for-profit O sectors O Born O in O Bradford O BiB O receives O core O infrastructure O funding O from O the O Wellcome B-ORG Trust I-ORG WT101597MA O and O a O joint O grant O from O the O UK B-ORG Medical I-ORG Research I-ORG Council I-ORG MRC I-ORG and I-ORG UK I-ORG Economic I-ORG and I-ORG Social I-ORG Science I-ORG Research I-ORG Council I-ORG ESRC O MR/N024397/1 O and O one O from O the O British B-ORG Heart I-ORG Foundation I-ORG BHF O CS/16/4/32482 O The O National O Institute O for O Health O Research O Yorkshire O and O Humber O ARC O and O Clinical O Research O Network O both O provide O support O for O BiB O research O SLOPE O was O supported O by O an O Academy B-ORG of I-ORG Medical I-ORG Sciences I-ORG and I-ORG Wellcome I-ORG Trust I-ORG Grant O AMS_HOP001\1060 O This O work O was O supported O by O a O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O grant O funded O by O the O Korean O government O NRF-2018R1D1A1B07048376 O a O grant O from O the O Marine O Biotechnology O Program O funded O by O the O Ministry B-ORG of I-ORG Oceans I-ORG and I-ORG Fisheries I-ORG 20150220 O and O a O grant O from O the O Samsung B-ORG Biomedical I-ORG Research I-ORG Institute I-ORG SMX1180141 O The O authors O are O grateful O to O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32272466 O for O its O support O This O research O was O also O supported O by O the O Key B-ORG R&D I-ORG Program I-ORG of I-ORG Shanwei I-ORG 2022A008 O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG 2021A1515010644 O 2021A1515110396 B-AWARD and O Guangzhou B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG 202201010008 O The O current O study O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG grant O nos O BK20171474 B-AWARD BK20180501 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 31572647 B-AWARD the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG grant O no. O B200202142 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG grant O no. O 2019M651666 B-AWARD and O the B-ORG CAS I-ORG Pioneer I-ORG Hundred I-ORG Talents I-ORG Program I-ORG grant O no. O 2018-085 B-AWARD This O research O was O sponsored O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO. O 31371872),http://fund.sciencenet.cn/index.php/item/view/207237 B-AWARD the O Public B-ORG Projects I-ORG of I-ORG Zhejiang I-ORG Province I-ORG NO. O 2015C32017),http://www.zjkjt.gov.cn/news/node01/detail0101/2015/0101_61846.htm B-AWARD the O Program B-ORG of I-ORG Health I-ORG and I-ORG Medicine I-ORG Science I-ORG in I-ORG Zhejiang I-ORG Province I-ORG NO. O 2015RCA003),http://www.doc88.com/p-6572488490711.html B-AWARD Major B-ORG Science I-ORG and I-ORG Technology I-ORG Special I-ORG Projects I-ORG of I-ORG Zhejiang I-ORG China I-ORG NO. O 2013C03045-1 B-AWARD and O Zhejiang O Provincial O Program O for O the O Cultivation O of O High-level O Innovative O Health O Talents,http://www.decmin.com/zj_view.asp?id=919 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O Guangxi B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2022GXNSFBA035448 O Guangxi B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG GuiKe O AA22068099 O and O the O National B-ORG Modern I-ORG Agricultural I-ORG Industry I-ORG Technology I-ORG System I-ORG Guangxi I-ORG Dairy I-ORG Buffalo I-ORG In I-ORG novation I-ORG Team I-ORG Project I-ORG nycytxgxcxtd-2021-21-03 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31772643 B-AWARD the O Special B-ORG Research I-ORG Funding I-ORG for I-ORG Discipline I-ORG Construction I-ORG in I-ORG Sichuan I-ORG Agricultural I-ORG University I-ORG No. O 03570126 B-AWARD and O Sichuan B-ORG Longda I-ORG Animal I-ORG Husbandry I-ORG Science I-ORG and I-ORG Technology I-ORG Co I-ORG Ltd I-ORG No. O 2015SCLD001 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 51504168 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG no. O 2015CFB230 B-AWARD and O Science B-ORG Foundation I-ORG of I-ORG Wuhan I-ORG Institute I-ORG of I-ORG Technology I-ORG no. O K201754 B-AWARD This O study O was O supported O in O part O through O the O Johns B-ORG Hopkins I-ORG Center I-ORG of I-ORG Excellence I-ORG in I-ORG Regulatory I-ORG Science I-ORG and I-ORG Innovation I-ORG U01FD004977-03 O through O the O National B-ORG Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute I-ORG of O the O National O Institutes O of O Health O T32HL139426 O and O through O the O National B-ORG Institute I-ORG of I-ORG Diabetes I-ORG and I-ORG Digestive I-ORG and I-ORG Kidney I-ORG Diseases I-ORG R01DK120518 O The O funding O sources O had O no O role O in O the O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31501759 O 31601766 B-AWARD National B-ORG Key I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0100204-25 O Key B-ORG Technology I-ORG R I-ORG I-ORG D I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BE2016379 O and O Jiangsu B-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Fund I-ORG JASTIF O CX B-AWARD 16) I-AWARD 1012 O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Key B-ORG Special I-ORG Project I-ORG of I-ORG National I-ORG Key I-ORG R&D I-ORG Plan I-ORG No. O 2019YFC1907200 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 52078394 B-AWARD 52234004 B-AWARD and O 51461135003 B-AWARD and O Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG No. O 2021YJ0530 B-AWARD National B-ORG key I-ORG research I-ORG and I-ORG development I-ORG program I-ORG 2018YFD0502000 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG #31360537 O 31660640 I-AWARD 31860628 O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Inner I-ORG Mongolia I-ORG #2017MS0356 O The B-ORG Major I-ORG projects I-ORG of I-ORG Inner I-ORG Mongolia I-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2016ZD02 O The O funding O bodies O played O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31160039 B-AWARD and O 31570307 B-AWARD the O Russian B-ORG Foundation I-ORG for I-ORG Basic I-ORG Research I-ORG grant O 18-54-54005 B-AWARD Viet-a O and O the O Federal B-ORG Agency I-ORG for I-ORG Scientific I-ORG Organizations I-ORG Program I-ORG for I-ORG Bioresource I-ORG Collections I-ORG Russia I-ORG 0126-2017-0005 O The O work O of O Maxim O S. O Nuraliev O was O carried O out O in O accordance O to O Government O order O for O the O Lomonosov B-ORG Moscow I-ORG State I-ORG University I-ORG project O No. O AAAA-A16-116021660105-3 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Vietnam B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG grant O number O NĐT/IT/21/19 B-AWARD the O Vietnam B-ORG National I-ORG Foundation I-ORG for I-ORG Science I-ORG I-ORG Technology I-ORG Development I-ORG NAFOSTED O grant O number O 108.05-2017.30 B-AWARD and O the O Vietnam B-ORG National I-ORG University I-ORG VNU-HCM O grant O number O C2021-18-10/HĐ-KHCN B-AWARD This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41430749 O 31670433 B-AWARD 31470524 B-AWARD 31500427 B-AWARD 31570512 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2014 O T70949 O 2015 B-AWARD M582735 O and O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Frozen I-ORG Soil I-ORG Engineering I-ORG SKLFSE200901 O This O work O was O supported O by O National B-ORG Key I-ORG R I-ORG I-ORG D I-ORG Program I-ORG for I-ORG Crop I-ORG Breeding I-ORG 2017YFD0102000 O National B-ORG Key I-ORG Technology I-ORG Support I-ORG Program I-ORG of I-ORG China I-ORG 2015BAD02B02 O and O Jiangsu B-ORG Collaborative I-ORG Innovation I-ORG Center I-ORG for I-ORG Modern I-ORG Crop I-ORG Production I-ORG project I-ORG No.10 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Financial O support O for O this O study O was O provided O by O National B-ORG Aeronautics I-ORG and I-ORG Space I-ORG Administration’s O Applied O Sciences O Program O in O Health O and O Air O Quality O Grant O NNX15AF36G B-AWARD OCW O also O acknowledges O support O from O the O National B-ORG Science I-ORG Foundation I-ORG Graduate O Research O Fellowship O Grant O No. O 1650042 B-AWARD CMB O acknowledges O support O from O the O Pacific O Southwest O Regional O Center O of O Excellence O for O Vector-Borne O Diseases O funded O by O the O U.S B-ORG Centers I-ORG for I-ORG Disease I-ORG Control I-ORG and I-ORG Prevention I-ORG Cooperative O Agreement O U01CK000516 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31360041 B-AWARD and I-AWARD 31660052 O the O 2011 B-ORG Collaboration I-ORG Innovation I-ORG Center I-ORG Construction I-ORG Program I-ORG of I-ORG Guizhou I-ORG Province I-ORG no. O 2014]01 B-AWARD and O the O High-level B-ORG Innovation I-ORG Talents I-ORG Training I-ORG Program I-ORG of I-ORG Guizhou I-ORG Province I-ORG no. O 2016]4003 B-AWARD This O work O was O supported O by O the O CAMS B-ORG Initiative I-ORG for I-ORG Innovative I-ORG Medicine I-ORG 2017-I2M-3-001 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81771757 O 81671620 I-AWARD 81971545 O the O Capital B-ORG Health I-ORG Research I-ORG and I-ORG Development I-ORG Special I-ORG 2020-2-4017 O the O Nonprofit O Central O Research O Institute O Fund O of O the O Chinese O Academy O of O Medical O Sciences O NWB20203346 O and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFC0901500 O This O study O was O supported O by O grants O from O the B-ORG Public I-ORG Welfare I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG of I-ORG China I-ORG 2014C37006 O Wenzhou B-ORG Science I-ORG and I-ORG Technology I-ORG project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG of I-ORG China(Y20130164)Zhejiang O Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant I-ORG LQ17H120009 O Wenzhou O Science O and O Technology O project O of O Zhejiang O Province O of O China O Y20140217 O This O work O was O partly O supported O by O the O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81672797 O 81530043 B-AWARD and I-AWARD 81930085 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFA0107500 O and O the B-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Radiation I-ORG Medicine I-ORG and I-ORG Protection I-ORG GZN1201804 O GZN1201903 O This O work O was O supported O by O funding O from O the O European O Union's O Horizon B-ORG 2020 I-ORG research O and O innovation O program O under O Marie O Skłodowska-Curie O Grant O agreement O no. O 751699 B-AWARD to O UK, O through O a O MRC/BBSRC B-ORG Grant O MR/N007174/1 O to O UK O and O WG, O a O MRC O Grant O MR/S037713/1 O to O WG O and O a O NERC B-ORG Innovation O People O scheme O award O NE/S006257/1 O to O WG. O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 32102679 B-AWARD 31972685 B-AWARD and O 31920103015 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG grant O number O 2020M681741 B-AWARD the B-ORG 111 I-ORG Project I-ORG D18007 O and O the B-ORG Priority I-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG grant O number O PAPD B-AWARD This O work O was O funded O in O part O by O grants O from O the O Cystic B-ORG Fibrosis I-ORG Foundation I-ORG HOGAN19G0 O STANTO19R0 B-AWARD the O National B-ORG Science I-ORG Foundation I-ORG 1458359 O the O Gordon B-ORG and I-ORG Betty I-ORG Moore I-ORG Foundation I-ORG GBMF O 4552 B-AWARD and O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG T32 O GM008704 O R01 B-AWARD HG010067 O R01 B-AWARD CA237170 O and O R01 B-AWARD CA200854 O This O research O was O funded O by O the O National B-ORG Eye I-ORG Institute I-ORG grants O R01EY030054-01A1 B-AWARD and O R01EY023315 B-AWARD M.A.-S O the O American B-ORG Heart I-ORG Association I-ORG Grant O 18CDA34080403 B-AWARD A.S.I O NIH O core O grant O P30EY004068 O to O the O Department O of O Ophthalmology O Visual O and O Anatomical O Sciences O OVAS O and O a O Research O to O Prevent O Blindness O unrestricted O grant O to O the O Department O of O OVAS O Wayne O State O University O Detroit O MI, O USA O Chinese O Cultural O Bureau O to O F.W O and O M.W O Research O reported O in O this O publication O was O additionally O supported O by O The O Macular O Degeneration O Foundation O The O Carl O Marshall O Reeves O O Mildred O Almen O Reeves O Foundation O Inc O the B-ORG National I-ORG Institutes I-ORG of I-ORG Health I-ORG Core O Grant O EY014800 B-AWARD Unrestricted O Grant O from O Research O to O Prevent O Blindness O Inc O New O York O NY, O to O the O Department O of O Ophthalmology O O Visual O Sciences O University O of O Utah O Eunice O Kennedy O Shriver O National O Institute O of O Child O Health O O Human O Development O and O the O Office O of O Research O on O Women’s O Eye O Health O of O the O National O Institutes O of O Health O under O Award O K12HD08582 B-AWARD The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O national O Institutes O of O Health O This O work O was O funding O by O Marie B-ORG Sklodowska-Curie I-ORG Research I-ORG and I-ORG Innovation I-ORG Staff I-ORG Exchanges I-ORG RISE O under O the O grant O agreement O No O 823989 B-AWARD “IONBIKE” O CONICET B-ORG PIP O 11220200101353CO O ANPCyT B-ORG PICT-2020-03156 O and O the O National B-ORG University I-ORG of I-ORG the I-ORG Litoral I-ORG C.A.I O I-AWARD D I-AWARD 50620190100117LI O and O Fundação B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG a I-ORG Tecnologia I-ORG 2020.01555.CEECIND O UIDB/50006/2020 B-AWARD and O UIDP/50006/2020 B-AWARD This O work O was O financially O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41872239 O and O 91955311 B-AWARD the O Second B-ORG Tibetan I-ORG Plateau I-ORG Scientific I-ORG Expedition I-ORG and I-ORG Research I-ORG Program I-ORG 2019QZKK0708 O and O the O China B-ORG Geological I-ORG Survey I-ORG DD20221644 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Youth I-ORG Foundation I-ORG of I-ORG China I-ORG 61803128 O 61501149 O Postdoctoral B-ORG Fund I-ORG of I-ORG China I-ORG 2016M601437 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG LH2019F026 O This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFB0903800 B-AWARD the B-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Advanced I-ORG Power I-ORG Transmission I-ORG Technology I-ORG Grant O No. O GEIRI-SKL-2018-014 B-AWARD and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No. O 2019MS011,2019MS083 B-AWARD 2016YQ08 O This O work O was O supported O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20191160 O Open B-ORG Research I-ORG of I-ORG the I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Computer I-ORG Architecture I-ORG CARCH201901 O QingLan B-ORG Project I-ORG and I-ORG Changzhou I-ORG Sci&Tech I-ORG Program I-ORG CJ20200071 B-AWARD 2020029 O This O work O was O supported O by O the O Army B-ORG Research I-ORG Office I-ORG through O Grant O No. O W911NF-18-1-0345 B-AWARD TC O the O NIH B-ORG through O Grant O No. O R01HL146552 B-AWARD TC O and O the O NSF B-ORG through O Grant O No. O DMS-1814090 B-AWARD MRD O The O funders O had O no O role O in O the O design O and O conduct O of O the O study O the O collection O management O analysis O and O interpretation O of O the O data O the O preparation O or O review O of O the O article O or O the O decision O to O submit O the O article O for O publication O This O work O was O supported O by O the O Fondo B-ORG Nacional I-ORG de I-ORG Desarrollo I-ORG Científico I-ORG y I-ORG Tecnológico I-ORG FONDECYT I-ORG grant O 1160627 B-AWARD to O Juan O C. O Opazo O by O the O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG CIHR I-ORG grant O MOP B-AWARD 133711 I-AWARD and O by O the O Natural B-ORG Sciences I-ORG and I-ORG Engineering I-ORG Research I-ORG Council I-ORG of I-ORG Canada I-ORG NSERC I-ORG Dicovery I-ORG Grant I-ORG grant O application O No. O 418113-2012 B-AWARD NSERC I-AWARD PIN I-AWARD 392027 I-AWARD to O Roberto O Araya O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the B-ORG National I-ORG key I-ORG research I-ORG and I-ORG development I-ORG plan I-ORG project I-ORG No. O 2016YFD0500904 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG C2016028 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O No. O 31302127 B-AWARD and O Fund B-ORG of I-ORG Heilongjiang I-ORG Province I-ORG Education I-ORG Department I-ORG 12541003 O The O funding O bodies O played O no O role O in O the O design O of O the O study O data O collection O analysis O interpretation O or O in O writing O the O manuscript O This O work O was O supported O by O the O UK O Engineering B-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG grant O numbers O EP/L016044/1 B-AWARD EP/S024093/1 B-AWARD the O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG grant O number O BB/P010008/1 B-AWARD and O the O Wellcome B-ORG Trust I-ORG grant O number O 212203/Z/18/Z B-AWARD Aditi O Agrawal O acknowledges O EPSRC O and O F. O Hoffmann‐La O Roche O Ltd O for O studentship O support O via O the O Centre O for O Doctoral O Training O in O Systems O Approaches O to O Biomedical O Science O D.J.G O acknowledges O support O from O the O EPSRC O Centres O for O Doctoral O Training O Programme O Jonathan O Cooper O Gary O R. O Mirams O Michael O Clerx O and O David O J. O Gavaghan O acknowledge O support O from O a O BBSRC O project O grant O Gary O R. O Mirams O and O Michael O Clerx O acknowledge O support O from O the O Wellcome O Trust O via O a O Wellcome O Trust O Senior O Research O Fellowship O to O G.R.M O This O research O was O funded O in O whole O or O in O part O by O the O Wellcome O Trust O 212203/Z/18/Z O Open O access O funding O provided O by O Umea O University O This O work O was O supported O by O project O grants O from O the O Swedish B-ORG Research I-ORG Council I-ORG grants O 2015-03007 O 2015-06824 B-AWARD 2018-02914 B-AWARD Kempe B-ORG Foundations I-ORG grants O JCK-1527 O JCK-1724 B-AWARD and O HEC B-ORG Pakistan I-ORG Grant O 8666/Punjab/NRPU/2017 O The O work O was O performed O as O part O of O the O Umeå O Centre O for O Microbial O Research O UCMR O Linnaeus O Program O at O The O Laboratory O for O Molecular O Infection O Medicine O Sweden O MIMS O with O support O from O Umeå O University O and O the O Swedish O Research O Council O grants O 2007-8673 O and O 2016-06598 O The O funders O had O no O role O in O study O design O data O collection O and O interpretation O or O the O decision O to O submit O the O work O for O publication O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 62175070 O 61875057 O The B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG China I-ORG 2021A1515012652 O and O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG 2019050001 O This O project O was O funded O by O a O Wellcome B-ORG Trust I-ORG Intermediate I-ORG Clinical I-ORG Fellowship I-ORG Grant O No. O 098522 B-AWARD awarded O to O RTM O LBS O was O supported O by O MRC B-ORG Programme O Grant O MR/N002970/1 B-AWARD RAA O was O supported O by O MRC O Programme O Grant O G1100357/1 O RMS O was O supported O by O MRC O Programme O Grant O G33253 O This O work O was O undertaken O in O the O MRC B-ORG Centre I-ORG for O Reproductive O Health O which O is O funded O by O the O MRC O Centre O grant O MR/N022556/1 B-AWARD The O funding O bodies O had O no O input O into O the O conduct O of O the O research O or O the O production O of O this O manuscript O The O authors O have O declared O no O conflicts O of O interest O This O study O was O funded O by O an O IBioIC O PhD O studentship O L.W O a O Leverhulme B-ORG Trust I-ORG Research O Project O H.D O and O M.H.T O project O no. O RPG-2014-418 O a O Leverhulme O Trust–Royal O Society I-ORG Africa O award O K.K O and O H.D O AA090088 B-AWARD the O jointly O funded O UK O Medical B-ORG Research I-ORG Council–UK O Department O for O International O Development O MRC/DFID O concordat O agreement O African O Research O Leaders O Award O K.K O and O H.D O MR/S00520X/1 B-AWARD and O the O Royal O Society–NSFC O Newton O Mobility O Grant O Award O IEC\NSFC\170617 O to O H.D O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81701341 O and I-AWARD 81801343 O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Liwan I-ORG District I-ORG of I-ORG GuangZhou I-ORG 202004034 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0906300 O Science B-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Guangdong I-ORG Province I-ORG Major I-ORG Science I-ORG and I-ORG Technology I-ORG 2016B010108003 O and O Guangzhou B-ORG Municipal I-ORG Psychiatric I-ORG Disease I-ORG Clinical I-ORG Transformation I-ORG Laboratory I-ORG 201805010009 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Wellcome B-ORG Trust I-ORG 097419/Z/11/Z O and O Science B-ORG Foundation I-ORG Ireland I-ORG 12IA1343 O FAPESP B-ORG Process O 2014/04811-6 O for O the O Research O Internships O Abroad O BEPE O allowed O THRP O to O visit O UCD O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O partly O funded O by O the O European B-ORG Union’s I-ORG Horizon I-ORG 2020 I-ORG research I-ORG and I-ORG innovation I-ORG program I-ORG under O grant O agreement O No O 874724 B-AWARD Equal-Life O Equal-Life O is O part O of O the O European O Human O Exposome O Network O Data O collection O in O FinnTwin12 O has O been O supported O by O National B-ORG Institute I-ORG of I-ORG Alcohol I-ORG Abuse I-ORG and I-ORG Alcoholism I-ORG grants O AA-12502 B-AWARD AA-00145 B-AWARD and O AA-09203 B-AWARD to O R. O J. O Rose O and O the O Academy B-ORG of I-ORG Finland I-ORG grants O 100499 B-AWARD 205585 B-AWARD 118555 B-AWARD 141054 B-AWARD 264146 B-AWARD 308248 B-AWARD 312073 B-AWARD and O 336823 B-AWARD to O J.K O J.K O acknowledges O support O by O the O Academy O of O Finland O grants O 265240 B-AWARD 263278 B-AWARD and O 352792 B-AWARD This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFE019550 O 2017YFC1308501 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2019QNA5027 O K20200185 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31627802 O 81571769 B-AWARD the O Zhejiang B-ORG Laboratory I-ORG 2018EB0ZX01 O Zhejiang O University O Education O Foundation O Global O Partnership O Fund O and O Zhejiang O Province O Key O R&D O Programs O 2018C01037 O 2020C03039 O This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. I-AWARD 81100412 O the B-ORG 59th I-ORG General I-ORG Project I-ORG of I-ORG China I-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. I-AWARD 2016M592038 O and O the B-ORG Key I-ORG Project I-ORG of I-ORG the I-ORG Supporting I-ORG Program I-ORG for I-ORG Excellent I-ORG Young I-ORG Talents I-ORG in I-ORG Colleges I-ORG and I-ORG Universities I-ORG in I-ORG 2016 I-ORG Grant O No. I-AWARD gxyqZD2016059 O This O work O was O supported O by O National O High-level O personnel O of O special O support O program O 2014189 O YangFan O Innovative O O Entepreneurial O Research O Team O Project O 201312H05 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21701051 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017A030313051 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2016M600705 O Fundamental O Research O Funds O for O the O Central O Universities O and O Guangdong O Frontier O Key O Technological O Innovation O Special O Funds O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81502616 B-AWARD the O National B-ORG Social I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 16BGL183 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG No. O 2017JM8013 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O BBSRC(studentship B-ORG BB/K011782/1),MRC(project B-AWARD MR/P026362/1),Wellcome B-AWARD Trust(programme O 086867/Z/08/Z B-AWARD andArthritis O Research I-ORG UK(Career O Development O Fellowship O 19909 B-AWARD to O LVN O This O research O was O funded O by O Agenzia B-ORG Spaziale I-ORG Italiana I-ORG ASI O Italy O grant O number O 2016-6-U.0 B-AWARD European B-ORG Space I-ORG Agency I-ORG ESA O grant O number O CORA-2017-IBER_001 B-AWARD Fondazione O Cassa O di O Risparmio O di O Firenze O Italy O and O a O Research O Grant O from O the O University B-ORG of I-ORG Pisa I-ORG PRA O 2019 O This O research O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31500177 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O GK201603065 B-AWARD and O Shaanxi B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG No. O 2016JQ3025 B-AWARD The O funding O body O didn’t O participate O any O activities O regarding O the O paper O including O design O of O the O study O sampling O collection O analysis O data O interpretation O and O in O manuscript O writing O This O work O is O supported O in O part O by O grants O from O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O China O 2017A030310094 O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou O China O 201707010218 O Agricultural B-ORG basic I-ORG long-term I-ORG scientific I-ORG and I-ORG technological I-ORG work I-ORG ZX01S200101 O and O Provincial O Science O and O technology O project O of O Guangdong O 2014B070706013 O 2016B070701011 O 2017B030314173 O and O 2017A070702006 O This O study O was O supported O by O grants O from O the B-ORG Non-profit I-ORG Central I-ORG Research I-ORG Institute I-ORG Fund I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG 2018PT32029 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. I-AWARD 81570195 O the B-ORG Beijing I-ORG Natural I-ORG Science I-ORG Foundation I-ORG grant O no. I-AWARD 7142130 O the B-ORG Specialized I-ORG Research I-ORG Fund I-ORG for I-ORG the I-ORG Doctoral I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG grant O no. I-AWARD 2013110611000 O the B-ORG Peking I-ORG Union I-ORG Medical I-ORG College I-ORG New I-ORG Star I-ORG 2011 O for I-AWARD J. I-AWARD Li O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 32260293 B-AWARD the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Gansu I-ORG Province I-ORG no. O 21JR11RA023 B-AWARD the B-ORG Scientific I-ORG Research I-ORG Project I-ORG for I-ORG Colleges I-ORG and I-ORG Universities I-ORG of I-ORG Gansu I-ORG Province I-ORG no. O 2022QB-017 B-AWARD the B-ORG Research I-ORG Fund I-ORG for I-ORG Humanities I-ORG and I-ORG Social I-ORG Sciences I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG no. O 20XJAZH006 B-AWARD the B-ORG Foundation I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG no. O 31920220061 B-AWARD 31920220041 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31261140363 O 31301102 B-AWARD National B-ORG and I-ORG International I-ORG Bioscience I-ORG and I-ORG Biotechnology I-ORG Cooperation I-ORG Project I-ORG from I-ORG China I-ORG Research I-ORG Seed I-ORG Collection I-ORG and I-ORG Reproduction I-ORG in I-ORG Biofuel I-ORG Crops I-ORG 2008DFA32030 O Scholarship B-ORG Foundation I-ORG of I-ORG China I-ORG 201503260021 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hainan I-ORG Province I-ORG 20163118 O and O A B-ORG New I-ORG Type I-ORG of I-ORG Molecular I-ORG Breeding I-ORG Technology I-ORG Based I-ORG on I-ORG the I-ORG Second I-ORG Generation I-ORG Sequencing I-ORG P153020016 O The O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31902222 O Y.W O 31672498 B-AWARD H.Z O and O 31872431 B-AWARD F.H O Science B-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Zhejiang I-ORG Province O China O 2016C02054-11 O F.H O and O the O Modern B-ORG Agroindustry I-ORG Technology I-ORG Research I-ORG System I-ORG CARS-44 O F.H O and O H.Z O This O work O was O financially O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC1403000/2016YFC1403002 O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDA13020500 O and O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG 2015BAL04B04 O The O funding O agencies O had O no O role O in O the O design O analysis O and O interpretation O of O the O data O or O writing O of O the O manuscript O This O work O was O jointly O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 82073546 B-AWARD 82073533 B-AWARD 81773416 B-AWARD the O Nutrition B-ORG Research I-ORG Foundation I-ORG of I-ORG the I-ORG Chinese I-ORG Nutrition I-ORG Society I-ORG No. O CNS-ZD2019049 B-AWARD and O the O 5010 O Program O for O Clinical O Researches O No. O 2007032 B-AWARD of O Sun B-ORG Yat-Sen I-ORG University I-ORG Guangzhou O China O This O study O was O supported O by O the O Project B-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Simulation I-ORG and I-ORG Regulation I-ORG of I-ORG Water I-ORG Cycle I-ORG in I-ORG River I-ORG Basin I-ORG SKL2018CG02 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51439007 B-AWARD and O the O IWHR B-ORG Research I-ORG and I-ORG Development I-ORG Support I-ORG Program I-ORG WE0145B532017 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2019YFA0210201 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 11974433 O 91833301 B-AWARD 11974122 B-AWARD 52072416 B-AWARD 51702372 B-AWARD Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG 2021A1515012636 O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG 202002030102 O 202102020810 B-AWARD and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Sun I-ORG Yat-sen I-ORG University I-ORG 22lgqb18 O This O study O was O partially O supported O by O the O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81572067 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG No.2016J05185 O and O the O Youth B-ORG Foundation I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG Fujian I-ORG Province O No.2016-1-55 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 31700568 B-AWARD the O Certificate B-ORG of I-ORG China I-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG grant O number O 2018T110989 B-AWARD the O China O Postdoctoral O Science O Foundation O grant O number O 2016M602705 B-AWARD and O the O College O Students’ O Innovation O and O Entrepreneurship O Training O Program O of O Sichuan O Province O grant O number O 201810626117 B-AWARD This O work O was O supported O by O the B-ORG science I-ORG and I-ORG technology I-ORG department’s I-ORG major I-ORG program I-ORG of I-ORG Henan I-ORG China I-ORG 161100311100 O the B-ORG national I-ORG health I-ORG and I-ORG family I-ORG planning I-ORG commission I-ORG in I-ORG China I-ORG 201601010 O The B-ORG education I-ORG department’s I-ORG Project I-ORG of I-ORG Henan I-ORG China I-ORG 19A320052 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O numbers O 11505060 B-AWARD 11875129 B-AWARD and O 11435010 B-AWARD the O Beijing B-ORG Nova I-ORG Program O grant O number O xx2018057 B-AWARD the O Fund O of O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Intense I-ORG Pulsed I-ORG Radiation I-ORG Simulation I-ORG and I-ORG Effect O grant O number O SKLIPR1810 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities O grant O number O 2018YQ01 B-AWARD The O APC O was O funded O by O the O National O Natural O Science O Foundation O of O China O grant O number O 11875129 O This O research O was O performed O in O the O framework O of O the O state O assignment O of O FASO B-ORG Russia I-ORG theme O No. O 0149-2018-0009 B-AWARD and O was O supported O by O RFBR B-ORG grant O 16-04-00064 B-AWARD sample O collections O and O preparation O of O manuscript O and O RSF B-ORG grant O 14-50-00029 B-AWARD molecular O analysis O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O main O RYK O iNCK O trial O was O funded O by O Grand B-ORG Challenges I-ORG Canada I-ORG S4 O 0230-01 O UBS B-ORG Optimus I-ORG Foundation I-ORG 6793_UBSOF O and O SKM O was O the O recipient O of O the O March O of O Dimes B-ORG Foundation I-ORG Basil I-ORG O’Connor I-ORG Starter I-ORG Scholar I-ORG Award I-ORG #5-FY14-48 O for O this O work O Baby O Hero O https://babyhe.ro O further O supported O the O study O SKM O received O support O from O the O Canadian O Child O Health O Clinician O Scientist O Program O Career O Development O Award O JD O received O support O from O the O Division O of O Neonatology O at O the O University O of O Toronto O The O funders O of O the O study O had O no O role O in O study O design O data O collection O analysis O and O interpretation O This O work O was O supported O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG National I-ORG Institute I-ORG of I-ORG Neurological I-ORG Disorders I-ORG and I-ORG Stroke I-ORG 5R01NS043788-04 B-AWARD http://www.ninds.nih.gov O GEH O National B-ORG Institutes I-ORG of I-ORG Health I-ORG National I-ORG Institute I-ORG of I-ORG Eunice I-ORG Kennedy I-ORG Shriver I-ORG National I-ORG Institute I-ORG of I-ORG Child I-ORG Health I-ORG I-ORG Human I-ORG Development O 5U01HD066435-05 B-AWARD https://www.nichd.nih.gov O GEH O Pilot B-ORG and I-ORG Feasibility I-ORG grant I-ORG from I-ORG Clinical I-ORG Nutrition I-ORG Research I-ORG Unit I-ORG of I-ORG Maryland O P30DK072488 B-AWARD http://grantome.com/grant/NIH/P30-DK072488-05S1 O GEH O National B-ORG Institute I-ORG of I-ORG Health I-ORG National I-ORG Center I-ORG for I-ORG Research I-ORG Resources O 5G12RR017581-05 B-AWARD http://www.nih.gov/about/almanac/organization/NCRR.htm O MK O National B-ORG Institutes I-ORG of I-ORG Health I-ORG National I-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences O 5S06GM051971-05 B-AWARD http://www.nigms.nih.gov/Pages/default.aspx O MK O TEDCO O Technology O Development O Corporation O of O Maryland,http://tedco.md/)/U.S O Army O contract O Q81XWH-07-2-0055 O MK. O TEDCO O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O project O was O supported O by O an O NSF B-ORG Career O grant O 0953390 B-AWARD and O Army B-ORG Research I-ORG Office I-ORG grant O W911NF-14-1-0556 B-AWARD awarded O to O RRD O and O a O Howard B-ORG Hughes I-ORG Medical I-ORG Institute I-ORG grant O 52006933 B-AWARD through O the O Precollege O and O Undergraduate O Science O Education O Program O http://www.hhmi.org/grants/office/undergrad O awarded O to O NC O State O University O DJF O and O HLM O were O supported O by O NSF O grant O 1319293 B-AWARD awarded O to O RRD O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG BB/J015881/1 O Medical B-ORG Research I-ORG Council I-ORG MC_ O U12266B O Wellcome B-ORG Trust I-ORG 101472/Z/13/Z O The O present O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31770537 B-AWARD Lanzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG Project O 2017-RC-64 O Gansu B-ORG Administration I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG Project I-ORG GZK-2019-47 O Cuiying B-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG Program I-ORG of I-ORG Lanzhou I-ORG University I-ORG Second I-ORG Hospital I-ORG CY2017-QN20 O This O project O was O funded O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31800301 O Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG for I-ORG Chinese I-ORG Academy I-ORG of I-ORG Tropical I-ORG Agricultural I-ORG Sciences I-ORG 1630052016009 O 1630052019021 O and O the B-ORG International I-ORG Science I-ORG and I-ORG Technology I-ORG Cooperation I-ORG Program I-ORG of I-ORG China I-ORG 2014DFA30680 O The O funding O bodies O didn’t O participate O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O financially O supported O by O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Special O Fund O CXZX2017189 O Study O on O excavation O and O utilization O of O germplasm O resources O and O sub-tropical O fruit O trees O and O special O industrial O horticultural O crops O including O daisies O in O Fujian O province O The B-ORG Science I-ORG and I-ORG Technology I-ORG Plan O Major O projects O of O Fujian O Province O 2015NZ0002-1 O and O FAFU B-ORG innovation I-ORG funds I-ORG KF2015108 B-AWARD I-AWARD CXZX2016118 I-AWARD helped O with O study O design O data O collection O and O analyses O in O our O study O This O work O was O supported O by O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG of I-ORG China I-ORG CAAS-ASTIP-2015-LIHPS O the B-ORG Selection I-ORG of I-ORG Scientific I-ORG Research I-ORG Topics I-ORG for I-ORG Significant I-ORG Production I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG CAAS-ZDXT2018006 O the B-ORG Modern I-ORG China I-ORG Wool I-ORG Cashmere I-ORG Technology I-ORG Research I-ORG System I-ORG CARS-39-02 O Key O Research O the O Development O Program O of O Gansu O Provincial-Agricultural O Project O 17YF1NA069 O and O the O Central B-ORG Level I-ORG Scientific I-ORG Research I-ORG Institutes I-ORG for I-ORG Basic I-ORG R&D I-ORG Special I-ORG Fund I-ORG Business I-ORG 1610322019011 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O General B-ORG Projects I-ORG of I-ORG Humanities I-ORG and I-ORG Social I-ORG Sciences I-ORG Planning I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG 19YJCZH092 O the O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG LY17G030035 O the O National B-ORG Statistical I-ORG Science I-ORG Project I-ORG China I-ORG 2018LY29 O and O the O National B-ORG College I-ORG Students’ I-ORG Innovative I-ORG Entrepreneurial I-ORG Training I-ORG Program I-ORG of I-ORG China I-ORG 201810338044 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81873635 O 81902553 B-AWARD 82172685 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG 2019JJ50942 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2021T140750 O This O work O is O supported O by O the O National B-ORG Cancer I-ORG Institute I-ORG at I-ORG National I-ORG Institutes I-ORG of I-ORG Health I-ORG P01 O CA098993 I-AWARD to O SD O the O National B-ORG Institute I-ORG of I-ORG Environmental I-ORG Health I-ORG Sciences I-ORG at O the O National O Institutes O of O Health O 2-K99ES024417 O to O AP O and O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG of O the O National O Institutes O of O Health O Institutional O Development O Award O IDeA O grant O P20GM103449 O to O the O Vermont O Genetics O Network O VGN O This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFC0501707 B-AWARD the O Fund B-ORG Project I-ORG of I-ORG Shaanxi I-ORG Key I-ORG Laboratory I-ORG of I-ORG Land I-ORG Consolidation I-ORG 2019-JC15 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41771557 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O program O 451-03-47/2023-01/200134 B-AWARD of O the O Ministry B-ORG of I-ORG Science I-ORG Technological I-ORG Development I-ORG and I-ORG Innovations I-ORG of I-ORG the I-ORG Republic I-ORG of I-ORG Serbia O the O project O 142-451-3187/2022-01/01 B-AWARD financed O by O the O Provincial B-ORG Secretariat I-ORG for I-ORG Higher I-ORG Education I-ORG and I-ORG Scientific I-ORG Research I-ORG of I-ORG the I-ORG Autonomous I-ORG Province I-ORG of I-ORG Vojvodina O as O well O as O the O bilateral O project O between O the O Republic O of O Serbia O and O Hungary O financed O by O the O Ministry B-ORG of I-ORG Education I-ORG Science I-ORG and I-ORG Technological I-ORG development I-ORG of O the O Republic O of O Serbia O project O number O 451-03-01345/2020-09/7 B-AWARD and O by O the O Hungarian O National O Office O for O Research O Development O and O Innovation O NKFI O project O number O 2019-2.1.11-TÉT-2020-00249 O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG China I-ORG 2016YFD0500202-1 O and O 2016YFD0501601 O by O the O Jiangsu B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG BK20150444 O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31502076 O by O the O Postdoctoral B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG China I-ORG 1501015B O by O the B-ORG Special I-ORG Financial I-ORG Grant I-ORG from I-ORG the I-ORG China I-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2016T90515 O by O the O ‘Qing O Lan O Project’ O of O Higher O Education O Institutions O of O Jiangsu O Province O China O by O the O ‘High-end O talent O support O program’ O of O Yangzhou O University O China O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Higher I-ORG Education I-ORG Institutions I-ORG of I-ORG Jiangsu I-ORG Province I-ORG China I-ORG 15KJB230006 O by O the B-ORG earmarked I-ORG fund I-ORG for I-ORG Modern I-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG nycytx-41-G07 O and O by O A O Project O Funded O by O the O Priority O Academic O Program O Development O of O Jiangsu O Higher O Education O Institutions O PAPD O This O work O was O supported O by O a O PhD O grant O from O the O China B-ORG Scholarship I-ORG Council I-ORG CSC O 2011633060 O and O a O co-grant O from O Ghent B-ORG University I-ORG BOF O 01SC3312 O for O Xiuqin O WU. O The O isotope O and O fatty O acid O analyses O were O supported O by O the O Flemish B-ORG Science I-ORG Foundation I-ORG through O project O 3G.0192.09 B-AWARD and O Ghent B-ORG University I-ORG through I-ORG GOA-project I-ORG 01GA1911W O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG GM008224 O National B-ORG Cancer I-ORG Institute I-ORG CA206573 O National B-ORG Institute I-ORG of I-ORG Neurological I-ORG Disorders I-ORG and I-ORG Stroke I-ORG NS083660 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 32122067 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20200084 O and O BK20220155 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG JUSRP622013 B-AWARD This O work O is O Supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.51875004 O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No.3172004 O the O China O Scholarship O Council O CSC O for O one-year O study O in O University O of O Alberta O for O Fan O Jiang O International B-ORG Research I-ORG Cooperation I-ORG Seed I-ORG Fund I-ORG of I-ORG Beijing I-ORG University I-ORG of I-ORG Technology I-ORG No.2018B16 O the O open O project O of O Beijing O Engineering O Researching O Center O of O Laser O Technology O BG0046-2018-09 O and O start-up O funding O from O Beijing O University O of O Technology O This O work O is O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2018YFB1801101 O the O National B-ORG Science I-ORG Fund I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG No. O 61925102 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO. O 92167202 O NO. B-AWARD 62201086 O and O NO. B-AWARD 62101069 O and O BUPT-CMCC B-ORG Joint I-ORG Innovation I-ORG Center I-ORG CMYJY-202000276 O This O research O was O funded O by O ERDF B-ORG project I-ORG no. O 1.1.1.1/19/A/089 B-AWARD “Birch O bark O as O a O valuable O renewable O raw O material O for O producing O formaldehyde-free O particle O boards O and O suberinic O acids O polyols O for O the O development O of O polyurethanes” O and O partly O funded O by O “BarkBuild—Tree O bark I-ORG as I-ORG a I-ORG re-newable I-ORG source I-ORG of I-ORG wood I-ORG protection I-ORG materials I-ORG for I-ORG building I-ORG applications” O ES O RTD/2022/14 I-AWARD within O ERA-NET O Cofund O Action O “ForestValue—Innovating O the O forest-based O bioeconomy” O Project O BarkBuild O is O supported O under O the O umbrella O of O ERA-NET O Cofund O ForestValue O by O Valsts O izglītības O attīstības O aģentūra O Latvia O Vinnova O Sweden O Ministry O of O Education O Science O and O Sport O MIZS O Slovenia O Academy O of O Finland O The O Research O Council O of O Norway O and O The O National O Science O Centre O Poland O ForestValue O has O received O funding O from O the O European B-ORG Union’s I-ORG Horizon I-ORG 2020 I-ORG re-search I-ORG and I-ORG innovation I-ORG programme I-ORG under O grant O agreement O No. O 773324 B-AWARD This O publication O was O supported O by O the O Latvian B-ORG Academy I-ORG of I-ORG Sciences I-ORG and I-ORG Czech I-ORG Academy I-ORG of I-ORG Sciences I-ORG mobility I-ORG project I-ORG “Innovative I-ORG bio-based I-ORG polyols I-ORG and I-ORG advanced I-ORG methods I-ORG of I-ORG their I-ORG characterization” O project O No. O LZA-22-02 B-AWARD This O work O was O supported O by O the O “National O Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China” O 2017YFD0501200 O and O the O “National O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China” O 31711540022 O and O the O “China O Postdoctoral I-ORG Science I-ORG Foundation” O 2018M641567 O This O study O was O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG Grant O No. O 2018YFA0902500 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG Grant O No. O 2018A030313139 B-AWARD Joint O R&D O Project O of O Shenzhen-Hong O Kong O Innovation O Grant O No. O SGLH20180622152010394 O Hong O Kong O Innovation O and O Technology O Commission O TCFS O GHP/087/18SZ O and O sponsored O by O the O Shenzhen O Taifeng O East O Marine O Biotechnology O Co. O Ltd O Natural O Science O Foundation O of O Shenzhen O Grant O No. O KQJSCX20180328093806045 O Shenzhen O science O and O technology O application O demonstration O project O Grant O No. O KJYY20180201180253571 O and O Shenzhen B-ORG peacock I-ORG plan I-ORG Grant O No. O 827-000192 B-AWARD This O work O was O supported O by O grants O from O National O Science O and O Technology B-ORG Major I-ORG Project I-ORG for I-ORG Infectious I-ORG Diseases I-ORG of I-ORG China I-ORG 2012ZX10004503 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81201289 O the O International O Science O O Technology O Cooperation O Program O of O China O 2011DFA31030 O and O Deutsche B-ORG Forschungsgemeinschaft I-ORG DFG O Transregio I-AWARD TRR60 O This O work O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG 13th I-ORG Five-Year I-ORG Plan I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG No. O 2017YFD0400200 B-AWARD The O central B-ORG government I-ORG supports O the O reform O and O development O of O local O colleges O and O universities O to O fund O talent O training O projects O No. O 202012-202312 B-AWARD Talent B-ORG Foundation I-ORG of I-ORG the I-ORG Central I-ORG Government I-ORG Supporting I-ORG Local I-ORG Universities I-ORG No. O 2020GSP08 B-AWARD Harbin B-ORG University I-ORG of I-ORG Commerce I-ORG Graduate I-ORG Innovation I-ORG Fund I-ORG YJSCX2018-483HSD O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61705025 O the O Program B-ORG for I-ORG Innovation I-ORG Team I-ORG Building I-ORG at I-ORG Institutions I-ORG of I-ORG Higher I-ORG Education I-ORG in I-ORG Chongqing I-ORG CXTDX201601034 O the O Chongqing O Municipal O Key O Laboratory O of O Institutions O of O Higher O Education O Grant O No. I-AWARD 2017]3 O the O Program O of O Chongqing O Development O and O Reform O Commission O Grant O No. I-AWARD 2017[1007 O the O Chongqing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG cstc2018jcyjAX0817 O and O the O Science O and O Technology O Project O Affiliated O with O the O Education O Department O of O Chongqing O Municipality O KJQN201801217 O KJ1710247 O This O study O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2021YFC2102400 O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Animal I-ORG Nutrition I-ORG Project I-ORG 2004DA125184G2101 O the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG of I-ORG MOF I-ORG and I-ORG MARA I-ORG CARS-41 O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG cxgc-ias-16 O and O the O Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG 2022-YWF-ZYSQ-03 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Funds I-ORG of I-ORG China I-ORG 31570167 O 81401368 B-AWARD Shandong B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Program I-ORG 2014GSF121004 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG China(ZR2014HP025 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 42271283 B-AWARD Social B-ORG Science I-ORG Research I-ORG Fund I-ORG Project I-ORG of I-ORG Henan I-ORG Polytechnic I-ORG University I-ORG Nos O SKJZD2020-03 B-AWARD Program O for O Innovative O Research O Team O in O Philosophy O and O Social O Science O in O University B-ORG of I-ORG Henan I-ORG Province I-ORG Grant O No. O 2022-CXTD-02 B-AWARD This O work O was O supported O by O Sundhed B-ORG og I-ORG Sygdom I-ORG Det I-ORG Frie I-ORG Forskningsråd I-ORG 12-126802)http://ufm.dk/forskning-og-innovation/rad-og-udvalg/det-frie-forskningsrad(JBC O Novo B-ORG Nordisk I-ORG Fonden O NNF14CC0001)http://www.novonordiskfonden.dk/da(JBC O and O Kræftens B-ORG Bekæmpelse I-ORG The O Danish O Cancer O Society O R72-A4487-13-S2)https://www.cancer.dk/(JBC O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Key B-ORG Discipline I-ORG Research I-ORG Capacity I-ORG Improvement I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2021ZDJS006 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2021A1515010781 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32072730 O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangzhou I-ORG 202102080162 O and O the O Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG No. O 110243160002002 B-AWARD This O work O was O supported O by O a O National B-ORG Sciences I-ORG Foundation I-ORG of I-ORG China I-ORG award I-ORG http://www.nsfc.gov.cn/)(81471945 O to O Y. O Hu. O This O fund O provided O the O publication O This O work O was O supported O by O a O Natural B-ORG Science I-ORG Foundation I-ORG Project I-ORG of I-ORG CQ I-ORG CSTC I-ORG http://www.cstc.gov.cn/)(cstc2014jcyjA10075 O to O Y. O Hu. O This O fund O provided O the O data O collection O and O analysis O This O work O was O supported O by O a O Major B-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG program I-ORG http://www.nhfpc.gov.cn/)(2013ZX10002002 O to O AL.H O This O fund O provided O study O design O This O work O was O supported O by O a O Chongqing B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG http://www.cqhrss.gov.cn/u/cqhrss O Xm2014006 O to O Z.T O This O fund O provided O the O data O collection O and O analysis O This O work O was O supported O by O the B-ORG Scientific I-ORG and I-ORG Technological I-ORG Research I-ORG Program I-ORG of I-ORG Chongqing I-ORG Municipal I-ORG Education I-ORG Commission I-ORG http://www.cqedu.cn O KJ1400205 O to O Z.T O This O fund O provided O the O data O collection O and O analysis O This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project O Grant O Number O 2022YFE0198100 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province O Grant O Number O SBK20220085 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities O Grant O Number O ZJ21195012 B-AWARD and O ZJ21195017 B-AWARD and O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O funded O by O Ministry O of O Education O Science O and O Technology O Grant O Numbers O 2021R1A4A2001968 B-AWARD and O 2021K1A3A1A61003041 B-AWARD This O work O was O supported O by O the B-ORG national I-ORG basic I-ORG research I-ORG program I-ORG of I-ORG China I-ORG 2014CB O 542300 O and O the B-ORG research I-ORG special I-ORG fund I-ORG for I-ORG public I-ORG welfare I-ORG industry I-ORG of I-ORG health I-ORG of I-ORG China I-ORG NO. O 201302018 B-AWARD to O C.Y.Z O the B-ORG national I-ORG natural I-ORG science I-ORG foundation I-ORG of I-ORG China I-ORG NSFC O 81472021 B-AWARD and O 81672102 B-AWARD to O C.Z O the O national O natural O science O foundation O of O China O NSFC O 81401257 B-AWARD and O the B-ORG natural I-ORG science I-ORG foundation I-ORG of I-ORG Jiangsu I-ORG province I-ORG BK20140730 O to O C.W O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG LY15H180007 B-AWARD the O Medical B-ORG and I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2015KYB153 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81471704 B-AWARD supported O in O data O retrieval O and O statistics O This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2020YFF0305905 O Second B-ORG Tibetan I-ORG Plateau I-ORG Scientific I-ORG Expedition I-ORG and I-ORG Research I-ORG Program I-ORG STEP O 2019QZKK0201 O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Hebei I-ORG Academy I-ORG of I-ORG Sciences I-ORG 22107 O 22103 B-AWARD Basic B-ORG Research I-ORG Program I-ORG of I-ORG Shanxi I-ORG Province I-ORG 202203021211258 O 20210302123248 B-AWARD Shanxi B-ORG philosophy I-ORG and I-ORG social I-ORG science I-ORG planning I-ORG project I-ORG 2022YJ039 O University B-ORG Philosophy I-ORG and I-ORG Social I-ORG Science I-ORG Research I-ORG Project I-ORG of I-ORG Shanxi I-ORG Province I-ORG 2021W038 O This O work O was O supported O by: O Aarhus B-ORG University I-ORG Grant O number O 17117581 B-AWARD Central B-ORG Denmark I-ORG Region I-ORG Grant O number O A-111 B-AWARD 1-15-1-72-13-09 O The B-ORG Health I-ORG Foundation I-ORG Grant O number O 16-13-0098 B-AWARD The O Committee B-ORG of I-ORG Multipractice I-ORG Studies I-ORG in I-ORG General I-ORG Practice I-ORG Grant O number O 16-1461 B-AWARD and O TrygFonden B-ORG Grant O number O 119795 B-AWARD This O study O was O supported O by O grants O from O the O European B-ORG Community's I-ORG Seventh I-ORG Framework I-ORG Programme I-ORG MODHEP O consortium O the O Italian B-ORG Association I-ORG for I-ORG Research I-ORG on I-ORG Cancer I-ORG AIRC O grant O MFAG B-AWARD to O SG O the O Italian B-ORG Ministry I-ORG of I-ORG Health I-ORG Grant O GR B-AWARD to O SG) O and O the O Italian B-ORG Ministry I-ORG of I-ORG Education I-ORG University I-ORG and I-ORG Research I-ORG FIRB O Grant O INCA B-AWARD to O GN O AC O was O supported O by O Fondazione O Umberto O Veronesi O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O project O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 82071678 B-AWARD and O 82171683 B-AWARD the O Shanghai B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG Research I-ORG Fund I-ORG No. O 21140903800 B-AWARD the O Clinical B-ORG Research I-ORG Plan I-ORG of I-ORG SHDC I-ORG No. O SHDC2020CR2059B B-AWARD and O the O Key B-ORG Research I-ORG Project I-ORG of I-ORG Pudong I-ORG New I-ORG Area I-ORG Population I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG No. O PW2020E-1 B-AWARD DA O acknowledges O British B-ORG Heart I-ORG Foundation I-ORG Accelerator O Award O AA/18/5/34222 O Diabetes B-ORG UK I-ORG Grant O 19/0005973 O Barts O Charity O Grant O MRC O 0215 O Wellcome B-ORG Trust I-ORG 221604/Z/20/Z O for O funding O her O work O MJS O British O Heart O Foundation O Programme O Grant O RG/12/4/29426 O This O research O is O funded O by O the O the O Social B-ORG Undertakings I-ORG and I-ORG Livelihood I-ORG Security I-ORG Technology I-ORG Innovation I-ORG Projects I-ORG of I-ORG Chongqing I-ORG CSTC2015SHMSZX80020 O the O Project B-ORG of I-ORG Youth I-ORG Fund I-ORG of I-ORG Southwest I-ORG University I-ORG No. O 20700926 B-AWARD and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG XDJK2017D078 O The O funding O bodies O had O no O role O in O study O design O data O collection O or O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O in O part O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0113201 O the O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG LSY19H180002 O the O Medical B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2017PY013 O and O 2018PY005 B-AWARD and O the B-ORG Key I-ORG Laboratory I-ORG of I-ORG Radiation I-ORG Physics I-ORG and I-ORG Technology I-ORG Sichuan I-ORG University I-ORG Ministry I-ORG of I-ORG Education I-ORG 2018SCURPT09 O This O research O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31601979 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0500501 O the B-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG ASTIP-IAS07 O and O National B-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG 2012BAD39B01 O in O China O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31660584 B-AWARD and O No. O 31260473 B-AWARD the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-23-C-07 O and O the O Major B-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG Fund I-ORG of I-ORG Gansu I-ORG Province I-ORG No. O 17ZD2NA015 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O H.-J.C O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 11647001 B-AWARD and O 11804004 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2020M681973 B-AWARD Anhui B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 1708085QA11 B-AWARD and O Overseas B-ORG Visiting I-ORG and I-ORG Training I-ORG Program I-ORG for I-ORG Outstanding I-ORG Young I-ORG Backbone I-ORG Teachers I-ORG of I-ORG Universities I-ORG gxgwfx2021024 O This O work O was O supported O by O the O Key B-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG ZDRW-ZS-2016-3 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31470231 O Yanping O Zhang O is O supported O by O the O Youth B-ORG Innovation I-ORG Promotion I-ORG Association I-ORG CAS I-ORG No. O 2014076 O This O work O was O supported O by O the B-ORG Hong I-ORG Kong I-ORG Scholar I-ORG Program I-ORG XJ2018052 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61774021 O and O 61504010 B-AWARD the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2018XKJC05 O and O the B-ORG Fund I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Information I-ORG Photonics I-ORG and I-ORG Optical I-ORG Communications I-ORG Beijing I-ORG University I-ORG of I-ORG Posts I-ORG and I-ORG Telecommunications I-ORG P. I-ORG R. I-ORG China I-ORG IPOC2017ZT02 O This O research O was O funded O by O National B-ORG Research I-ORG Development I-ORG and I-ORG Innovation I-ORG Office I-ORG KMR_12-1-2012-0436 O nkfih.gov.hu O European B-ORG Cooperation I-ORG in I-ORG Science I-ORG and I-ORG Technology I-ORG 9878-3/2016/FEKUT,www.cost.eu O and O Hungarian B-ORG Government I-ORG Research O Centre I-AWARD of I-AWARD Excellence I-AWARD I-AWARD 11476-3/2016/FEKUT,www.nemzetikivalosag.hu O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Authors O who O received O the O funding O BF O TK O KS O CB O EL O ZC O GB O BU O ÁH O JC. O The O research O was O also O funded O by O the O owners O of O Applied O Cell O Technology O ltd O These O funders O provided O support O in O the O form O of O salaries O for O authors O BF, O KS, O CB, O EL, O JC O but O did O not O have O any O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O does O not O alter O our O adherence O to O PLOS O ONE O policies O on O sharing O data O and O materials O The O specific O roles O of O these O authors O are O articulated O in O the O authors’ O contribution O section O Design O of O the O study O and O collection O of O data O were O supported O by O the B-ORG National I-ORG Science I-ORG Grant I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG 81425001/H0104 O the B-ORG National I-ORG Key I-ORG Technology I-ORG Support I-ORG Program I-ORG from I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2015BAI12B11 O and O the B-ORG Beijing I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG D151100002115004 O This O study O is O supported O by O a O research O grant O from O the O KU B-ORG Leuven I-ORG Research O Fund O IDO O program O IDO/12/011 O ERC B-ORG Starting I-ORG Grant I-ORG N° O 241426 B-AWARD FWO B-ORG N° O G.0544.10N B-AWARD and O Human B-ORG Frontier I-ORG Science I-ORG Program I-ORG RGP0050/2013 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG No. O 1610172019010 O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-14-1-17 O National B-ORG Infrastructure I-ORG for I-ORG Crop I-ORG Germplasm I-ORG Resources I-ORG NCGRC-2022-016 O National B-ORG Program I-ORG for I-ORG Crop I-ORG Germplasm I-ORG Protection I-ORG of I-ORG China I-ORG 19221888-4 O and O Intellectual B-ORG Property I-ORG Project I-ORG of I-ORG Gansu I-ORG Province I-ORG 21 O ZSCQ026 O This O work O is O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81402732 O and O 81672020 B-AWARD Jiangsu B-ORG Province I-ORG Science I-ORG I-ORG Technology I-ORG Demonstration I-ORG Project I-ORG for I-ORG Emerging I-ORG Infectious I-ORG Diseases I-ORG Control I-ORG and I-ORG Prevention I-ORG No.BE2015714 O and O Scientific B-ORG and I-ORG technological I-ORG development I-ORG foundation I-ORG of I-ORG Wuxi I-ORG CSE31N1515 O The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O manuscript O preparation O This O work O is O supported O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2019YFB1600500 O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51775053 O and O the O Changjiang B-ORG Scholars I-ORG and I-ORG Innovative I-ORG Research I-ORG Team I-ORG in I-ORG University I-ORG IRT_17R95 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61373057 O to O Xiaobo O Li, O 61775139 B-AWARD to O Linhua O Jiang O the O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG LY17F020003 O to O Xiaobo O Li O the O Zhejiang B-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Digital I-ORG Design I-ORG and I-ORG Intelligent I-ORG Manufacturing I-ORG of I-ORG Characteristic I-ORG Cultural I-ORG and I-ORG Creative I-ORG Products I-ORG 2016E10007 O to O Xiaobo O Li O the O Shanghai B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 15ZR1420800 O to O Sihua O Peng O and O the O Jiaxing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 2015AY23012 O to O Jingyu O Wang O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O number O 2016YFA0101403 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 31660346 B-AWARD Yunnan B-ORG Medical I-ORG Scientific I-ORG Research I-ORG Foundation I-ORG grant O number O 2017NS248 B-AWARD and O Yunnan B-ORG Young I-ORG Leaders I-ORG in I-ORG Academic I-ORG and I-ORG Technical I-ORG Talents I-ORG Project I-ORG grant O number O 2012HB040 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O authors O acknowledge O financial O support O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81602718 O No. B-AWARD 81771839 O No. B-AWARD 81572999 I-AWARD and O No. B-AWARD 81773272 O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Oncogenes I-ORG and I-ORG Related I-ORG Genes I-ORG No.91-17-20 O Medical-Engineering B-ORG Joint I-ORG Funds I-ORG from I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG No. O YG2017QN43 O Shanghai B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG No. O 20174Y0123 O This O research O was O funded O by O National B-ORG agricultural I-ORG product I-ORG quality I-ORG and I-ORG safety I-ORG risk I-ORG assessment I-ORG project I-ORG of I-ORG China I-ORG GJFP201700302 O Xinjiang B-ORG Innovation I-ORG and I-ORG Development I-ORG Project I-ORG 2016D04016 O received O by O C.W O and O Xinjiang B-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG youth I-ORG fund I-ORG xjnkq-2015033 O received O by O W.H O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31601802 B-AWARD and O 31401932 B-AWARD the B-ORG Youth I-ORG Talent I-ORG Development I-ORG Plan I-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Agricultural I-ORG System I-ORG of I-ORG China I-ORG Grant O No. O 20160111 B-AWARD and O the B-ORG Shanghai I-ORG Municipal I-ORG Agricultural I-ORG Commission I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 20130510 B-AWARD This O work O supported O by O European B-ORG Commission I-ORG grant O number O NMP3-SL-2012-280670 B-AWARD Office B-ORG of I-ORG Energy I-ORG Efficiency I-ORG and I-ORG Renewable I-ORG Energy I-ORG grant O number O DE-AC02-07CH11358 B-AWARD Office B-ORG of I-ORG Science I-ORG grant O number O DE-AC02-76SF00515 B-AWARD The O study O was O supported O by O the O funding O of O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81771861 O 81971646 O Shanghai B-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG Program I-ORG No.18410711200 O 19142202100 O and O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No.2019YFC1604605 O The O study O was O supported O by O following O grants O Ministry B-ORG of I-ORG Health I-ORG Czech I-ORG Republic—conceptual I-ORG development I-ORG of I-ORG research I-ORG organization I-ORG MH O CZ—DRO I-AWARD FNOL I-AWARD 00098892 O Internal B-ORG Grant I-ORG Agency I-ORG of I-ORG the I-ORG Palacký I-ORG University I-ORG in I-ORG Olomouc I-ORG IGA O UP I-AWARD LF_2018_005 O IGA_LF_2019_003 B-AWARD Technology B-ORG Agency I-ORG of I-ORG the I-ORG Czech I-ORG Republic I-ORG TACR O TE02000058 O The B-ORG National I-ORG Center I-ORG for I-ORG Medical I-ORG Genomics I-ORG NCMG O LM2015091 O National B-ORG Programme I-ORG of I-ORG Sustainability I-ORG NPU O LO1304 O and O European B-ORG Regional I-ORG Development I-ORG Fund—Project I-ORG ENOCH I-ORG No. O CZ.02.1.01/0.0/0.0/16_019/0000868 B-AWARD There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 21773058 B-AWARD U1704251 I-AWARD 21733011 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFA0403101 O Project B-ORG funded I-ORG by I-ORG China I-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2017M622349 B-AWARD and O the O 111 B-ORG Project I-ORG No. O D17007 B-AWARD This O work O was O also O supported O by O the O High O Performance O Computing O Center O of O Henan O Normal O University O This O research O was O funded O by O the O New B-ORG Jersey I-ORG Commission I-ORG on I-ORG Spinal I-ORG Cord I-ORG Research I-ORG NJCSCR O 15IRG006 B-AWARD L.C O the O NIH B-ORG Biotechnology I-ORG Pre-Doctoral I-ORG Training I-ORG Fellowship I-ORG T32GM008339 B-AWARD T.C O and O B.R O and O the O NJCSCR B-ORG graduate I-ORG fellowship I-ORG 22FEL016 B-AWARD Z.F O This O work O was O supported O by O theNatural O Science I-ORG Foundation I-ORG of I-ORG China(No O 51202107 B-AWARD a O grant O from O theOpening O Funding I-ORG of I-ORG National I-ORG Laboratory I-ORG of I-ORG Solid I-ORG State I-ORG Microstructure(No O M26017 B-AWARD andFoundation O of I-ORG Henan I-ORG Educational I-ORG Committee(No O 16A140028 B-AWARD This O work O was O financed O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81572421 B-AWARD the B-ORG Jiangsu I-ORG Provincial I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Program I-ORG No. O H201555 B-AWARD Huai’an B-ORG Governmental I-ORG Science I-ORG Developing I-ORG program I-ORG No. O HACZ2014002 B-AWARD In O all O cases O the O funders O had O no O role O in O study O design O data O collection O analysis O and O interpretation O of O data O or O in O the O writing O of O the O manuscript O and O decision O to O submit O it O for O publication O This O project O was O supported O by O grants O from O Key B-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG of I-ORG Nanjing I-ORG Medicine I-ORG ZDX16001 O to O SW; O The O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81802093 B-AWARD to O HS; O Innovation B-ORG team I-ORG of I-ORG Jiangsu I-ORG provincial I-ORG health-strengthening I-ORG engineering I-ORG by I-ORG science I-ORG and I-ORG education I-ORG CXTDB2017008 O Jiangsu B-ORG Youth I-ORG Medical I-ORG Talents I-ORG Training I-ORG Project I-ORG to O BH O QNRC2016066 O and O YP O QNRC2016074 O grants O from O Key O Project O of O Science O and O Technology O Development O of O Nanjing O Medicine O ZKX18030 O breast O cancer O Jiangsu B-ORG 333 I-ORG High-level I-ORG Talents I-ORG Cultivating I-ORG Project I-ORG to O BH O Gastric O cancer O no. O BRA201702 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 61675104 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG grant O no. O LY19F050002 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Ningbo I-ORG grant O no. O 2018A610316 B-AWARD the O K.C O Wong O Magna O Fund O in O Ningbo O University O China O Applied O Basic O Research O Project O of O Shanxi O Province O grant O no. O 201701D221096 O and O the O Science O and O Technology O Innovation O Project O of O University O of O Shanxi O Province O grant O no. O 2019L0746 O This O work O is O supported O by O Fundamental O Research O Funds O for O the O Central B-ORG Universities I-ORG of I-ORG Southwest I-ORG University I-ORG under O XDJK2016C005 B-AWARD and I-AWARD XDJK2017A002 O Postdoctoral B-ORG Science I-ORG Foundation I-ORG of I-ORG Chongqing I-ORG xm2014097 O and O Program B-ORG for I-ORG the I-ORG Youth I-ORG Talent I-ORG in I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Chongqing I-ORG cstc2014kjrc-qnrc50006 O This O work O was O supported O by O the O National B-ORG Social I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 15BTY023 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of O China O Grant O No. O 31500961and B-AWARD 31971099 B-AWARD as O a O key O project O of O the O Science B-ORG and I-ORG Education I-ORG Department I-ORG of I-ORG the I-ORG General I-ORG Administration I-ORG of I-ORG Sport I-ORG of I-ORG China I-ORG No. O 2017B009 B-AWARD the O Postgraduate B-ORG Research I-ORG Innovation I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG KYCX19_0738 B-AWARD and O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O Special B-ORG Fund I-ORG For I-ORG High-level I-ORG Talents I-ORG in I-ORG Beijing I-ORG Health I-ORG System I-ORG Project I-ORG 2011-3-079 O Beijing B-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospitals I-ORG Clinical I-ORG Medicine I-ORG Development I-ORG of I-ORG Special I-ORG Funding I-ORG Support I-ORG XMLX201502 O and I-AWARD XMLX201602 O and O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG China I-ORG 2018ZX09711003 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O authors O would O like O to O thank O the O Hong B-ORG Kong I-ORG General I-ORG Research I-ORG Fund I-ORG HKU172057/15E O Dr. O Y. O Mao O acknowledges O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51608329 O and O Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG Program I-ORG JCYJ20160520165135743 O This O work O was O supported O by O the B-ORG Jiangsu I-ORG Provincial I-ORG Medical I-ORG Youth I-ORG Talent I-ORG QNRC2016800 O the B-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Xuzhou I-ORG KC16SL111 O the B-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG H2017081 O and O the O Key O Medical B-ORG Subjects I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BE2015627 O This O study O was O realized O within O bilateral O project O cooperation O between O Serbia O and O Slovenia O supported O by O the O Ministry B-ORG of I-ORG Education I-ORG Science I-ORG and I-ORG Technological I-ORG Development I-ORG of I-ORG the I-ORG Republic I-ORG of I-ORG Serbia I-ORG Grant O No. O III46002 B-AWARD the O Slovenian B-ORG Research I-ORG Agency I-ORG ARRS O and O the O Ministry B-ORG of I-ORG Agriculture I-ORG Forestry I-ORG and I-ORG Food I-ORG grant O No. O L4 B-AWARD 5522 I-AWARD and O BI-RS/16-17-010 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31472054 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Nos O 2016YFC1000600 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG Central I-ORG South I-ORG University I-ORG Nos O 2019zzts715 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG Health I-ORG Commission I-ORG of I-ORG Hunan I-ORG Province(Grant O Number O C2019073 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82100846 O 82170870 B-AWARD 82120108008 B-AWARD Shanghai B-ORG Sailing I-ORG Program I-ORG 20YF1423500 O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG 19140902400 O Clinical B-ORG Research I-ORG Plan I-ORG of I-ORG SHDC I-ORG SHDC2020CR4006 O The O funders O played O no O role O in O the O design O or O conduction O of O the O study O in O the O collection O management O analysis O or O interpretation O of O the O data O or O in O the O preparation O review O or O approval O of O the O article O The B-ORG Strategic I-ORG Leading I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG “Black I-ORG soil I-ORG conservation I-ORG cultivation I-ORG tillage I-ORG and I-ORG recycling I-ORG agricultural I-ORG technology I-ORG systems” I-ORG No. O XDA28020400 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 41877024 B-AWARD and O the O Key B-ORG Laboratory I-ORG Foundation I-ORG of I-ORG Mollisols I-ORG Agroecology I-ORG 2020ZKHT-05 O This O work O was O supported O by O a O bilateral O interaction O project O Revisiting O DeHu O funded O by O the O Hungarian B-ORG National I-ORG Research I-ORG Development I-ORG and I-ORG Innovation I-ORG Office I-ORG grant O number O TéT_12_DE-1-2013-0007 B-AWARD to O AT] O and O the O German B-ORG Ministry I-ORG of I-ORG Education I-ORG and I-ORG Research I-ORG grant O number O 01DS14037 B-AWARD to O TL O Furthermore O TL O acknowledges O funding O to O this O work O by O the O European B-ORG Research I-ORG Council I-ORG ERC O under O the O European O Union’s O Seventh O Framework O Programme O FP7/2007-2013 O grant O agreement O No. O 616644 B-AWARD POLLOX O AS O was O supported O by O a O grant O of O the O Deutsche B-ORG Forschungsgemeinschaft I-ORG DFG O within O the O Priority O Program O ‘Biological O transformation O of O hydrocarbons O in O the O absence O of O oxygen’ O SPP O 1319 O grant O LU B-AWARD 118/4-2 O IS O was O supported O by O the O János O Bolyai O Research O Grant O of O the O Hungarian O Academy O of O Sciences O Haizhibao O company O supported O travel O expenses O and O incentives O for O consulting O Haizhibao O company O provided O support O in O the O form O of O consulting O incentive O for O author O S.M O Kim O but O did O not O have O any O additional O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O specific O roles O of O these O authors O are O articulated O in O the O ‘author O contributions’ O section O This O does O not O alter O our O adherence O to O PLOS O ONE O policies O on O sharing O data O and O materials O Additionally O this O research O was O a O part O of O the O project O 20170071 O entitled O “Future O Marine O Technology O Development” O funded O by O the O Ministry B-ORG of I-ORG Oceans I-ORG and I-ORG Fisheries O Republic O of O Korea O Open B-ORG Foundation I-ORG of I-ORG the I-ORG Heilongjiang I-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Environmental I-ORG Microbiology I-ORG and I-ORG Recycling I-ORG of I-ORG Argo-Waste I-ORG in I-ORG Cold I-ORG Region I-ORG 201707 O and O Scientific B-ORG Research I-ORG Staring I-ORG Foundation I-ORG in I-ORG HBAU I-ORG XZR2014-15 O No O additional O external O funding O was O received O for O this O study O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFB1107202 O 2017YFB1104700 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 91750205 B-AWARD 61774155 B-AWARD 61705227 B-AWARD K.C O Wong O Education O Foundation O GJTD-2018-08 O Scientific O Research O Project O of O the O Chinese O Academy O of O Sciences O QYZDB-SSW-SYS038 O Bill O O Melinda O Gates O Foundation O of O the O US O OPP1157723 O The O Key O Program O of O the O International O Partnership O Program O of O CAS O 181722KYSB20160015 O Jilin O Science O and O Technology O Department O Project O 20180414019GH O Chinese O Academy O of O Sciences O President’s O International O Fellowship O Initiative O PIFI O 2018VSA0001 O MEPhI O Academic O Excellence O Project O Contract O No. O 02.a03.21.0005 O for O the O access O to O the O infrastructure O and O scientific O databases O Russian B-ORG Science I-ORG Foundation I-ORG Project O 19-72-30012 B-AWARD for O the O development O of O theoretical O model O Deutsche B-ORG Forschungsgemeinschaft I-ORG DFG O IV I-AWARD 122/4-1 O GA B-AWARD 465/15-2 O and O Government O of O the O Russian O Federation O Grant O 074-U01 O for O ITMO O University O for O accessing O preliminary O treatment O of O the O samples O This O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 31800963 B-AWARD 81621003 B-AWARD and O 81820108018 B-AWARD the O Program O for O Changjiang O Scholars O and O Innovative O Research O Team O in O University O PCSIRT O Grant O No. O IRT16R52 O of O China O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2019 B-AWARD M653421 O and O the O Postdoctoral O Interdisciplinary O Research O Project O of O Sichuan O University O Dr O Gong O would O also O like O to O acknowledge O the O support O from O his O Changjiang B-ORG Scholar I-ORG Professorship I-ORG Award I-ORG Award O No. O T2014190 B-AWARD of O China O and O the O American O CMB B-ORG Distinguished O Professorship O Award O Award O No. O F510000/G16916411 B-AWARD administered O by O the O Institute O of O International O Education O USA O This O work O was O supported O by O theBritish O Heart I-ORG Foundation(RG/13/2/30098),British O Medical O Research O Council(K013351),the O British O Health O and O Safety O Executive O the O British O Department O of O Health O the O British O Stroke O Association(TSA O 2008/05 O the O USNational O Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute(R01HL036310 O and O the O USNational O Institute I-ORG on I-ORG Aging(R01AG013196andR01AG034454 O M.K O is O additionally O supported O by O a O professorial O fellowship O from O the O Economic O and O Social O Research O Council O and O by O NordForsk O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 12222201 O 82273500 B-AWARD U20A20390 B-AWARD 11827803 B-AWARD and O 11972351 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG ZG140S1971 O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2021YFA0719302 O Peking B-ORG University I-ORG Health I-ORG Science I-ORG Center-X I-ORG Cross I-ORG Seed I-ORG Fund I-ORG BMU2020MX014 O and O Incubation B-ORG fund I-ORG for I-ORG reserve I-ORG candidates I-ORG of I-ORG Peking I-ORG University I-ORG Third I-ORG Hospital I-ORG BYSYFY2021007 O This O work O was O supported O by O theQuanzhou O Science I-ORG and I-ORG Technology I-ORG Bureauunder O Grant O number O 2018Z010 B-AWARD and O the O work O was O also O supported O by O theFujian O science I-ORG and I-ORG technology I-ORG departmentunder O Grant O number O 2019R0057 B-AWARD and O the O work O was O also O supported O by O the10.13039/501100003815Huaqiao O Universityunder O Grant O number O 17BS201 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 31270160 B-AWARD J1310037 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province O China O grant O number O LY12C03003 B-AWARD and O the O Zhejiang B-ORG Public I-ORG Welfare I-ORG Technology I-ORG Application I-ORG Research I-ORG Project I-ORG grant O numbers O 2016C33084 B-AWARD This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31902282 O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Qinghai I-ORG Agriculture I-ORG and I-ORG Pastoral I-ORG Department I-ORG NMSY-2018-07 O and O Qinghai B-ORG province I-ORG Major I-ORG R&D I-ORG and I-ORG Transformation I-ORG Project I-ORG 2018-NK-125 O The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O or O writing O of O the O manuscript O This O research O was O funded O by O the O National O Key O R&D O Program O of O China O 2016YFD0400505 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31671851 O Tianjin B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG 19YFLHSN00030 O 18PTSYJC00140 O Tianjin B-ORG Municipal I-ORG Education I-ORG Commission I-ORG 2018ZD08 O TD13-5013 O Tianjin O Municipal O Human O Resource O and O Social O Security O Bureau O TJQYBSH2018010 O and O Key O Laboratory O of O Industrial O Fermentation O Microbiology O Education O Ministry O of O China O 2018KF005 O This O study O is O supported O in O part O by O Taiwan B-ORG Ministry I-ORG of I-ORG Health I-ORG and I-ORG Welfare I-ORG Clinical I-ORG Trial I-ORG Center I-ORG MOHW106-TDU-B-212-113004 O China B-ORG Medical I-ORG University I-ORG Hospital I-ORG Academia I-ORG Sinica I-ORG Taiwan I-ORG Biobank I-ORG Stroke I-ORG Biosignature I-ORG Project I-ORG BM10601010036 O Taiwan B-ORG Clinical I-ORG Trial I-ORG Consortium I-ORG for I-ORG Stroke I-ORG MOST O 106-2321-B-039-005 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tencológico I-ORG CNPq O fellowship O 308903/2021-8 B-AWARD Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG CAPES O Finance O Code O 001 O and O fellowship O 1594978 B-AWARD and O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo I-ORG FAPESP O grant O numbers O 2017/24856-2 B-AWARD 2013/20094-0 B-AWARD 2013/11164-4 B-AWARD and O 2009/12202-1 B-AWARD This O study O was O supported O by O grants O of O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81700658 O and I-AWARD 81771722 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG 2016JJ4105 O the O New B-ORG Xiangya I-ORG Talent I-ORG Project I-ORG of I-ORG the I-ORG Third I-ORG Xiangya I-ORG Hospital I-ORG of I-ORG Central I-ORG South I-ORG University I-ORG JY201629 O and O the O University B-ORG Student I-ORG Innovation I-ORG Program I-ORG of I-ORG Central I-ORG South I-ORG University I-ORG ZY20180983 O and I-AWARD ZY20180988 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O work O in O our O groups O are O funded O by O Health B-ORG Research I-ORG Board I-ORG grant O number O HRA-POR-2014-643 B-AWARD Science B-ORG Foundation I-ORG Ireland I-ORG SFI O grant O co-funded O under O the O European O Regional O Development O Fund O grant O Number O 13/RC/2073 B-AWARD SFI O Starting O Investigator O Grant O grant O number O 15/SIRG/3528 B-AWARD EU O H2020 O MSCA O ITN-675448 O TRAINERS O EU O H2020 O MSCA O RISE-734749 O INSPIRED O and O Irish B-ORG Research I-ORG Council I-ORG Fellowship O grant O number O GOIPD/2014/53 B-AWARD This O work O was O supported O by O the B-ORG Japan I-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG Grants-in-Aid I-ORG for I-ORG Scientific I-ORG Research I-ORG JSPS O KAKENHI O Grant O Number O 16K08560 B-AWARD the B-ORG Smoking I-ORG Research I-ORG Foundation I-ORG Grant O Number O 2019-22 B-AWARD and O the O Vehicle B-ORG Racing I-ORG Commemorative I-ORG Foundation I-ORG 2020 B-AWARD This O work O was O supported O by O grants O of O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81973663 O 81873269 B-AWARD and O 81602917 B-AWARD the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC1705500 O and O Talent B-ORG Project I-ORG of I-ORG Zhejiang I-ORG Association I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG 2018YCGC003 O This O work O was O sponsored O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFD0500404 B-AWARD awarded O to O YQ, O Program B-ORG of I-ORG International I-ORG S&T I-ORG Cooperation I-ORG No. O 2014DFE30140 B-AWARD and O the O FP-7 B-ORG project I-ORG LinkTADs I-ORG No.613804 O awarded O to O ZM. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Austrian B-ORG Science I-ORG Fund I-ORG FWF O project O P O 27687-N29 B-AWARD the O Deutsche B-ORG Forschungsgemeinschaft I-ORG DFG O Ha I-AWARD 6300/3-2 O and O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDB26000000 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Funding O for O this O work O was O provided O by O the O National B-ORG Aeronautics I-ORG and I-ORG Space I-ORG Administration I-ORG Astrobiology O Institute O NNA17BB05A O FR, O the O National B-ORG Science I-ORG Foundation I-ORG DEB-1457701 O MDH O O FR, O and O the O John B-ORG Templeton I-ORG Foundation I-ORG 43285 O MDH O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Hungarian B-ORG Scientific I-ORG Research I-ORG Fund I-ORG NKFIH O K116855 B-AWARD K124298 B-AWARD KH126885 B-AWARD to O L.N O GINOP-2.3.2-15-2016-0006 O GINOP-2.1.7-15-2016-01487 O NIH B-ORG R01DK115924 O Campus O Hungary O Scholarship O at O Centro O Nacional O de O Análisis O Genómico O to O A.H O American B-ORG Heart I-ORG Association I-ORG AHA O 17POST33660450 O to O B.D O Funding O for O open O access O charge O Hungarian O Scientific O Research O Fund O NKFIH O K116855 O K124298 O KH126885 O NIH O R01DK115924 O GINOP O 2.1.7-15-2016-01487 O GINOP O 2.3.2-15-2016-0006 O This O work O was O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O number O 2016YFD0500206 B-AWARD State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Veterinary I-ORG Etiological I-ORG Biology I-ORG Grant O number O SKLVEB2018KFKT006 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O number O 31772775 B-AWARD and O the O Priority O Academic O Program O Development O of O Jiangsu O Higher O Education O Institutions O PAPD O This O research O was O funded O by O a O grant O from O the O Japan B-ORG Agency I-ORG for I-ORG Medical I-ORG Research I-ORG and I-ORG Development I-ORG AMED O Grant O Number O JP16K1310001h0001 B-AWARD Health B-ORG Science I-ORG and I-ORG Labor I-ORG Research I-ORG Grants I-ORG HSLRG O Grant O Number O H30-Iryou-Ippan-013 B-AWARD of O the O Ministry O of O Health O Labour O and O Welfare O and O the O Japan B-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG JSPS I-ORG Grants-in-Aid I-ORG for I-ORG Scientific I-ORG Research I-ORG KAKENHI O Grant O Numbers O JP18H04126 B-AWARD JP20H00623 B-AWARD and O JP18K17390 B-AWARD This O work O was O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG LY17H030009 O and O LQ17H070002 B-AWARD Health B-ORG Bureau I-ORG of I-ORG Hangzhou I-ORG 2015A10 O Traditional B-ORG Chinese I-ORG Medicine I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2018ZA098 O Hangzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG 20163501Y09 O and O 20170533B42 B-AWARD This O work O was O supported O by O the O Australian B-ORG Research I-ORG Council I-ORG Discovery I-ORG Program I-ORG grant O number O DP130101421 B-AWARD awarded O to O TA O O WL; O Australian B-ORG Research I-ORG Council I-ORG Super I-ORG Science I-ORG Program I-ORG grant O number O FS110200046 B-AWARD awarded O to O TA; O and O the O Australian B-ORG Research I-ORG Council I-ORG Centre I-ORG of I-ORG Excellence I-ORG for I-ORG Coral I-ORG Reef I-ORG Studies I-ORG grant O number O CE0561435 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O Grants O from O the B-ORG Chinese I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O no. O 81671616 B-AWARD and O 81471603 B-AWARD Jiangsu B-ORG Provincial I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Foundation I-ORG Grant O no. O H201317 B-AWARD and O H201623 B-AWARD Science B-ORG Foundation I-ORG of I-ORG Nantong I-ORG City I-ORG Grant O no. O MS32015021 B-AWARD MS2201564 B-AWARD MS22016028 B-AWARD and O MS22016019 B-AWARD Science B-ORG and I-ORG Technology I-ORG Foundation I-ORG of I-ORG Nantong I-ORG City I-ORG Grant O no. O HS2014071 B-AWARD and O HS2016003 B-AWARD This O project O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 11872207 B-AWARD Aeronautical B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 20180952007 B-AWARD and O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Mechanics I-ORG and I-ORG Control I-ORG of I-ORG Mechanical I-ORG Structures I-ORG Grant O No. O MCMS-I-0520G01 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O no. O 51375380 B-AWARD Open B-ORG project I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG for I-ORG Strength I-ORG and I-ORG Vibration I-ORG of I-ORG Mechanical I-ORG Structures I-ORG of I-ORG China I-ORG Grant O no. O SV2016-KF-10 B-AWARD Shaanxi B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O no. O 2014JM2-5082 B-AWARD and O Scientific B-ORG Research I-ORG Program I-ORG of I-ORG Shaanxi I-ORG Provincial I-ORG Education I-ORG Department I-ORG of I-ORG China I-ORG Grant O no. O 15JS068 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O China B-ORG Scholarship I-ORG Council I-ORG CSC O 201606290095 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O Grant O No. O 51175432 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No. O 3102014JCS05007 B-AWARD the O Innovation O Platform O of O Biofabrication O Grant O No. O 17SF0002 B-AWARD the O Key O Research O and O Development O program O of O Shaanxi O Province O Grant O No. O 2018ZDXM-GY-133 B-AWARD and O Natural B-ORG Sciences I-ORG and I-ORG Engineering I-ORG Research I-ORG Council I-ORG of I-ORG Canada I-ORG NSERCRGPIN-2014-05648 O This O research O was O supported O by O the O Climate B-AWARD Change I-AWARD Adaptation I-AWARD Research I-AWARD Program I-AWARD of O National B-ORG Institute I-ORG for I-ORG Environmental I-ORG Studies I-ORG of I-ORG Japan I-ORG NIES O the O Environment O Research O and O Technology O Development O Fund O of O the O Environmental B-ORG Restoration I-ORG and I-ORG Conservation I-ORG Agency I-ORG of O Japan O S-14-5 O the O Climate O Change O Correspondence O Program O of O the O Ministry B-ORG of I-ORG Environment I-ORG of O Republic O of O Korea O 2014001310010 O the O National B-ORG Research I-ORG Foundation I-ORG NRF O of O Republic O of O Korea O MSIP O No.2017R1C1B2002663 O and O the O Basic O Science O Research O Program O through O the O NRF O funded O by O the O Ministry B-ORG of I-ORG Education I-ORG of O Korea O NRF-2018R1D1A1B07049034 O The O funding O source O had O no O role O in O the O study O design O in O the O collection O analysis O and O interpretation O of O data O in O the O writing O of O the O report O or O in O the O decision O to O submit O the O article O for O publication O The O Brazilian B-ORG Council I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Development I-ORG process O 154062/2014-6 B-AWARD provided O a O master O scholarship O for O the O author O Gabriel O L. O Osés O Micro-Raman O equipment O Astrobiology O Laboratory O Institute O of O Astronomy O Geophysics O and O Atmospheric O Sciences O University O of O São O Paulo O USP O update O was O funded O by O the O São B-ORG Paulo I-ORG Research I-ORG Foundation I-ORG FAPESP B-ORG project O 2012/18936-0 B-AWARD EDXRF O equipment O Institute O of O Physics O USP O acquisition O was O funded O by O FAPESP O process O 2012/00202-0 B-AWARD The B-ORG Brazilian I-ORG Nanotechnology I-ORG National I-ORG Laboratory I-ORG offered O their O SEM O equipment O under O the O Quanta O 15068 B-AWARD 16826 B-AWARD 16923 B-AWARD and O 18363 B-AWARD proposals O The O Brazilian B-ORG Synchrotron I-ORG Light I-ORG Laboratory I-ORG enabled O SXS O analyses O under O the O SXS O 14563 B-AWARD proposal O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O Chongqing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG cstc2018jcyjAX0203 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81701146 O Third B-ORG Military I-ORG Medical I-ORG University I-ORG “Miaopu” I-ORG talents I-ORG scheme I-ORG XZ-2019-505-064 O and O Southwest B-ORG Hospital I-ORG Science I-ORG Foundation I-ORG SWH2018QNKJ-02 O This O work O was O supported O by O National O Key O R&D O Plan O No. O 2016YFC1304104 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81400018 I-AWARD 81570028 I-AWARD and I-AWARD 81770039 O Shandong B-ORG Province I-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O ZR2017PH066 B-AWARD National O Basic O Research O Program O of O China O 973 O Program O No. O 2012CB933304 O National B-ORG Key I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG No. O 2013BAI09B00 B-AWARD Zhongshan O Hospital O Clinical O Research O Foundation O No. O 2016ZSLC05 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG No. O 15ZR1406400 B-AWARD and O Shanghai O Three-Year O Plan O of O the O Key O Subjects O Construction O in O Public O Health-Infectious O Diseases O and O Pathogenic O Microorganism O No. O 15GWZK0102 O This O work O was O supported O in O part O by O Project O PID2019-109481GB-100 B-AWARD of O the O Spanish B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Innovation O by O Project O 1264182-F B-AWARD of O the O Andalusian B-ORG Regional I-ORG Government O by O Project O PP2019-Submod-1.2 B-AWARD of O the O Cordoba B-ORG University I-ORG and O by O Project O AC25_2017 B-AWARD of O the O University B-ORG of I-ORG Informatics I-ORG Sciences I-ORG The O present O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81700562 O the B-ORG Shanxi I-ORG Province I-ORG 136 I-ORG Revitalization I-ORG Medical I-ORG Project I-ORG General O Surgery O Department O 2021YZ13 O the B-ORG Shanxi I-ORG Provincial I-ORG Guiding I-ORG Science I-ORG and I-ORG Technology I-ORG Special I-ORG Project I-ORG 2021XM42 O This B-ORG study I-ORG obtained I-ORG the I-ORG grants I-ORG from I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG R&D I-ORG Projects I-ORG of I-ORG Shanxi I-ORG Province I-ORG 201803D31151 O Excellent B-ORG Youth I-ORG Cultivation I-ORG Project I-ORG of I-ORG Shanxi I-ORG Province I-ORG 202103021222013 O This O study O was O funded O by O Beijing B-ORG Nova I-ORG Program I-ORG No. O Z1511000003150128 O Science B-ORG and I-ORG Technology I-ORG Special I-ORG Fund I-ORG for I-ORG Social I-ORG Development I-ORG of I-ORG Hainan I-ORG 2015SF45 O and O Hebei B-ORG Province I-ORG health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG Research I-ORG Fund I-ORG Project I-ORG 20181578 O This O study O was O supported O by O the O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81172832 O 81771723 B-AWARD Sichuan B-ORG Youth I-ORG Science I-ORG and I-ORG Technology I-ORG Foundation I-ORG No.2013JQ0020 O Special B-ORG Program I-ORG for I-ORG Sichuan I-ORG Youth I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG No.2014TD0010 O and O grant O from O Health B-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG Sichuan I-ORG Province I-ORG No.110190 O The O funding O body O did O not O have O any O role O in O the O study O design O nor O the O data O collection O analysis O and O interpretation O as O well O as O writing O of O the O manuscript O The O making O of O this O work O received O financial O support O by O the B-ORG Brazilian I-ORG National I-ORG Council I-ORG of I-ORG Technological I-ORG and I-ORG Scientific I-ORG Development I-ORG CNPq O Process O 155750/2019-4 B-AWARD Minas B-ORG Gerais I-ORG Research I-ORG Funding I-ORG Foundation I-ORG Fapemig O Process O RED-00132-16 B-AWARD and O Coordination B-ORG for I-ORG the I-ORG Improvement I-ORG of I-ORG Higher I-ORG Education I-ORG Personnel I-ORG CAPES O Process O 0622/2020/464 B-AWARD 88881.506612/2020-01 O and O Petrobras B-ORG SIGITEC O 2017/00587-2 O ANP B-AWARD n° I-AWARD 21035-1 O This O study O was O financially O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0502304 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31672562 O China–South B-ORG Africa I-ORG Joint I-ORG Research I-ORG Project I-ORG CS08-L13 O NBCIS B-ORG CARS-37 O ASTIP(CAAS-ASTIP-2016-LVRI B-ORG Jiangsu O Co-innovation O Center O Program O for O the O Prevention O and O Control O of O Important O Animal O Infectious O Diseases O and O Zoonoses O The O funders O had O no O role O in O the O study O design O data O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O or O decision O to O publish O This O work O was O supported O by O theUK O Biotechnology I-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council(BBSRC O BB/L027534/1 O aEuropean O Research I-ORG Councilgrant O ERC-2014-CoG O Grant O No O 646657 B-AWARD to O CK; O and O aWellcome O Trustgrant O Joint O Senior O Investigator O Award O No O 098433 B-AWARD to O JG. O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31670672 B-AWARD the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG Grant O No. O 2015BAD04B0302 B-AWARD and O the O Graduate B-ORG Innovation I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Agricultural I-ORG University I-ORG Grant O No. O 2019ysj-14 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31670692 O the O Basic B-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG Y2021GH06 O and O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG CAAS-ASTIP-2023-TRICAAS O This O work O was O supported O in O part O by O Grants-in-Aid B-ORG for I-ORG Scientific I-ORG Research I-ORG from I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG Culture I-ORG Sports I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Japan I-ORG 17K07579 O to O J O Abe O by O the B-ORG National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O nos O 31501330 B-AWARD to O M O Xu, O the B-ORG Program I-ORG of I-ORG the I-ORG General I-ORG Program I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O nos O 31771815 B-AWARD to O B O Liu O by O the O National O Natural O Science O Foundation O of O China O grant O nos O 31725021 B-AWARD to O F O Kong O and O by O the B-ORG Natural I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFE0111000 O and I-AWARD 2016YFD0100400 O to O F O Kong O This O study O was O supported O by O Support B-AWARD Project I-AWARD of I-AWARD Strategic I-AWARD Research I-AWARD Center I-AWARD in I-AWARD Private I-AWARD Universities I-AWARD from O the O MEXT B-ORG grants O from O the O Japan B-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG 15K15353 O to O SI, O 17H04205 B-AWARD to O KH-I O and O 16K09809 B-AWARD to O KI O and O Practical B-AWARD Research I-AWARD for I-AWARD Innovative I-AWARD Cancer I-AWARD Control I-AWARD JP18ck0106194 O and O Project B-AWARD for I-AWARD Cancer I-AWARD Research I-AWARD And I-AWARD Therapeutic I-AWARD Evolution I-AWARD P-CREATE O from O Japan O Agency O for O Medical O Research O and O Development O AMED O This O study O was O supported O by O the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFA0605100 O the B-ORG Key I-ORG Research I-ORG Program I-ORG of I-ORG Frontier I-ORG Sciences I-ORG CAS I-ORG QYZDJ-SSW-SMC027 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O nos O 31330008 B-AWARD 31370250 B-AWARD and O 31770238 B-AWARD and O the B-ORG Youth I-ORG Innovation I-ORG Promotion I-ORG Association I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG 2012070 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O grant O number O 81502860 B-AWARD the O Jiangsu B-ORG Provincial I-ORG Medical I-ORG Youth I-ORG Talent I-ORG under O grant O number O QNRC2016547 B-AWARD the B-ORG “333” I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG under O grant O number O BRA2017538 B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.31271135 O the O Scientific B-ORG Research I-ORG Fund I-ORG of I-ORG Hunan I-ORG Provincial I-ORG Education I-ORG Department I-ORG No.14C0705 O and O the O Cooperative B-ORG Innovation I-ORG Center I-ORG of I-ORG Engineering I-ORG and I-ORG New I-ORG Products I-ORG for I-ORG Developmental I-ORG Biology I-ORG of I-ORG Hunan I-ORG Province I-ORG No. O 20134486 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the B-ORG Key I-ORG Research I-ORG Project I-ORG of I-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG 2016YFD0500108 O the B-ORG Chinese I-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG 31672572 O the B-ORG Key I-ORG Project I-ORG of I-ORG Agriculture I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Shanghai I-ORG 2016043 O and O the B-ORG Foundation I-ORG of I-ORG Shanghai I-ORG Key I-ORG Laboratory I-ORG of I-ORG Veterinary I-ORG Biotechnology I-ORG klab201712 O The O funders O had O no O role O in O the O study O design O data O collection O analysis O and O interpretation O or O the O decision O to O submit O this O work O for O publication O ARW O and O TMF O are O supported O by O the O European B-ORG Research I-ORG Council I-ORG grant O 323195 B-AWARD SZ-245 I-AWARD 50371-GLUCOSEGENES-FP7-IDEAS-ERC O RMF O is O a O Sir O Henry O Dale O Fellow O Wellcome O Trust I-ORG and O Royal B-ORG Society O grant O 104150/Z/14/Z B-AWARD RB O is O funded O by O the O Wellcome O Trust O and O Royal O Society O grant O 104150/Z/14/Z O JT O is O funded O by O the O European O Regional O Development O Fund O and O a O Diabetes O Research O and O Wellness O Foundation O fellowship O SEJ O is O funded O by O the O Medical B-ORG Research I-ORG Council I-ORG grant O MR/M005070/1 B-AWARD MAT O MNW O and O AM O are O supported O by O the O Wellcome O Trust O Institutional O Strategic O Support O Award O WT097835MF O HY O is O funded O by O a O European O Research O Council O award O 323195 O The O funders O had O no O influence O on O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Special B-ORG Foundation I-ORG for I-ORG Emerging I-ORG Interdisciplinary I-ORG Field I-ORG Research I-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Health I-ORG Commission I-ORG Grant O No. O 2022JC004 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 82272040 B-AWARD the O First B-ORG Affiliated I-ORG Hospital I-ORG of I-ORG Naval I-ORG Medical I-ORG University I-ORG Shanghai I-ORG Changhai I-ORG Hospital I-ORG “Guhai I-ORG Plan I-ORG in I-ORG the I-ORG 14th I-ORG Five-Year I-ORG Plan I-ORG period” I-ORG Grant O No. O GH145-22 B-AWARD and O the O “Discipline B-ORG Construction I-ORG Climbing I-ORG 234 I-ORG Plan” I-ORG of I-ORG Shanghai I-ORG Changhai I-ORG Hospital I-ORG of I-ORG Naval I-ORG Medical I-ORG University I-ORG Grant O No. O 2019YPT002 B-AWARD and O 2020YPT002 B-AWARD This O work O was O supported O by O Japan O Society O for O the O Promotion O of O Science O Grants-in-Aid O for O Scientific O Research O Grants-in-Aid O for I-ORG Scientific I-ORG Research I-ORG B) O Grant O Number O JP23300160 B-AWARD to O YK] O and O Grants-in-Aid O for I-ORG Scientific I-ORG Research I-ORG S) O Grant O Number O JP16H06383 B-AWARD to O YK O Challenging O Exploratory I-ORG Research O Grant O Number O JP15K15625 B-AWARD to O YK O Grant-in-Aid O for I-ORG Research I-ORG Activity I-ORG start-up O Grant O Number O JP23890253 B-AWARD to O YS O and O Grant-in-Aid O for I-ORG Young I-ORG Scientists I-ORG B) O Grant O Number O JP15K18393 B-AWARD to O YS O https://www.jsps.go.jp/index.html O Accessed O 2016-12-19 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Jilin B-ORG Scientific I-ORG and I-ORG Technological I-ORG Development I-ORG Program I-ORG No. O 20230201090GX B-AWARD 20210101175JC B-AWARD the O Capital B-ORG Construction I-ORG Funds I-ORG within I-ORG the I-ORG Jilin I-ORG Province I-ORG budget I-ORG grant O 2022C043-2 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Research I-ORG Project I-ORG of I-ORG the I-ORG Education I-ORG Department I-ORG of I-ORG Jilin I-ORG Province I-ORG No. O JJKH20191309KJ B-AWARD and O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Experts I-ORG Project I-ORG No. O G2021130003L B-AWARD Ministerio B-ORG de I-ORG Economía I-ORG y I-ORG Competitividad I-ORG Spain O CGL2017-89160P O to O M.S O A.B O AGAUR B-ORG Generalitat O de I-ORG Catalunya O 2017SGR-1379 O to O A.R O Secretaria O d’Universitats O i O Recerca O del O Departament O d’Empresa O i O Coneixement O Generalitat O de O Catalunya O FI-DGR2015 O to O M.C.-Z O Departament O de O Genètica O i O de O Microbiologia O UAB O PIF O to O J.M.-M O Servei O de O Genòmica O i O Bioinformàtica O de O la O UAB O Funding O for O open O access O charge O Ministerio O de O Economía O y O Competitividad O Spain O The O results O of O the O project O were O created O with O the O financial O support O of O the O provider O Czech B-ORG Science I-ORG Foundation I-ORG within O the O project O No. O GA19-09980S B-AWARD Authors O thank O the O Research O Infrastructure O RECETOX O RI O No. O LM2018121 B-AWARD financed O by O the O Ministry B-ORG of I-ORG Education I-ORG Youth I-ORG and I-ORG Sports O and O Operational B-ORG Programme I-ORG Research I-ORG Development I-ORG and I-ORG Education—project O CETOCOEN O EXCELLENCE O No. O CZ.02.1.01/0.0/0.0/17_043/0009632 B-AWARD for O supportive O background O This O work O was O supported O from O the O European B-ORG Union’s I-ORG Horizon I-ORG 2020 I-ORG research O and O innovation O programme O under O grant O agreement O No. O 857560—CETOCOEN B-AWARD Excellence O This O publication O reflects O only O the O author's O view O and O the O European O Commission O is O not O responsible O for O any O use O that O may O be O made O of O the O in-formation O it O contains O The O research O was O also O supported O by O the O long-term O research O development O project O of O the O Institute B-ORG of I-ORG Botany I-ORG RVO O 67985939 O This O work O was O supported O by O Brazilian B-ORG grants I-ORG from I-ORG Conselho I-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq I-ORG grant I-ORG call I-ORG Universal I-ORG #405027/2021-4 O 427946/2018-2 B-AWARD CNPq B-ORG senior I-ORG research I-ORG fellowship I-ORG #309633/2021-4 O 307852/2019-9 B-AWARD 307689/2022-0 B-AWARD PPSUS B-ORG grant I-ORG funded I-ORG by I-ORG Decit/SCTIE/MS I-ORG intermediated I-ORG by I-ORG CNPq I-ORG with I-ORG the I-ORG support I-ORG of I-ORG Fundação I-ORG Araucária I-ORG and I-ORG SESA-PR I-ORG agreement O 041/2017 B-AWARD PRONEX B-ORG grant I-ORG supported I-ORG by I-ORG SETI/Fundação I-ORG Araucária I-ORG and I-ORG MCTI/CNPq I-ORG and I-ORG Governo I-ORG do I-ORG Estado I-ORG do I-ORG Paraná I-ORG agreement O 014/2017 B-AWARD Pesquisa B-ORG Básica I-ORG e I-ORG Aplicada I-ORG Grant I-ORG supported I-ORG by I-ORG SETI/Fundação I-ORG Araucária I-ORG UEL I-ORG #PBA2022011000198 O and O CAPES B-ORG finance O code O 001 O and O PROAP O process O 88881.652033/2021-1 O under O the O support O 487/2021 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31371065 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG No. O 17ZR1425800 B-AWARD This O work O was O supported O by O Medical B-ORG Professional I-ORG Cross I-ORG Research I-ORG Fund I-ORG Project I-ORG of I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG YG2015MS14 O This O study O was O supported O by O Initial B-ORG Scientific I-ORG Research I-ORG Fund I-ORG for I-ORG High-Level I-ORG Talents I-ORG of I-ORG Chengde I-ORG Medical I-ORG University I-ORG Grant O Numbers O 201809 B-AWARD 201901 B-AWARD Scientific B-ORG and I-ORG Technological I-ORG Research I-ORG Projects I-ORG of I-ORG Hebei I-ORG Higher I-ORG Education I-ORG Grant O Number O ZD2019084 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG Grant O Number O H2020406049 B-AWARD and O Medical B-ORG Science I-ORG Research I-ORG Foundation I-ORG of I-ORG Health I-ORG Commission I-ORG of I-ORG Hebei I-ORG Province I-ORG Grant O Number O 20190857 B-AWARD This O work O was O supported O in O part O by O Key B-ORG Discipline I-ORG Construction I-ORG in I-ORG Pudong I-ORG New I-ORG Area I-ORG Health I-ORG System I-ORG No.PWzx2014-14 O Pudong B-ORG New I-ORG Area I-ORG Science I-ORG and I-ORG Technology I-ORG Development-Innovation I-ORG Fund I-ORG No. O PKJ2013-Y39 B-AWARD and O Research B-ORG Grant I-ORG for I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Pudong I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG of I-ORG Shanghai I-ORG Grant O No. O PW2015B-4 B-AWARD The O funder O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0102000 O 2017YFD0100905 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31501311 I-AWARD 31771781 O and O the B-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG of I-ORG Sichuan I-ORG Province I-ORG No. O 2016HH0048 O Project O and O publication O costs O are O supported O by O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 5182018 O and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG PYBZ1834 O of O J.G O Y.W O is O partly O supported O by O a O grant O from O US B-ORG National I-ORG Science I-ORG Foundation I-ORG III-1526415 O The O funding O body O didn’t O play O any O roles O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O mainly O supported O by O the O International B-ORG Development I-ORG Research I-ORG Centre I-ORG IDRC O InnoVet-AMR O program O grant O no. O 109047 B-AWARD to O M.S O and O M.G O and O by O the O Natural B-ORG Sciences I-ORG and I-ORG Engineering I-ORG Research I-ORG Council I-ORG of I-ORG Canada I-ORG NSERC O through O grants O to O M.S O no. O 342150 B-AWARD and O to O M.G O no. O 04435 B-AWARD Partial O support O was O provided O by O Canadian B-ORG Glycomics I-ORG Network O funded O by O Networks O of O Centres O of O Excellence O of O Canada O grant O TP-6 B-AWARD to O M.S O M.G O and O R.R O and O Fonds O de O recherche O du O Québec—Nature O et O technologies O FRQNT O grant O no. O 2018-PR-206110 O to O M.S O M.G O and O R.R O The O research O was O funded O by O aNatural O Environment I-ORG Research I-ORG Council I-ORG NERC)GrantNE/D014166/1to O R.J.A O as O principal O investigator O A.C.B O was O supported O during O part O of O the O writing O of O this O paper O by O funding O fromEuropean O Commission I-ORG 7th I-ORG Framework I-ORG Programme I-ORG Capacities I-ORG Work I-ORG Programme(FP7-REGPOT O 2010-1),Grant O No.264125EcoGenes O This O work O was O supported O by O grants O from O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC1313300 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017A030313485 O 2014A030312015 O the O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangdong I-ORG 2019B020227002 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grants O 81872579 O 81573108 B-AWARD 81573191 B-AWARD New B-ORG Century I-ORG Excellent I-ORG Talents I-ORG in I-ORG University I-ORG from I-ORG Ministry I-ORG of I-ORG Education I-ORG NCET-13-0124 O and O Postgraduate B-ORG Research I-ORG I-ORG Practice I-ORG Innovation I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG KYCX17_0188 O and O Zhejiang B-ORG Province I-ORG Public I-ORG Technology I-ORG Application I-ORG Research I-ORG Project I-ORG No. O 2016C33218 B-AWARD This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Fund I-ORG of I-ORG China I-ORG Grant O 31701534 B-AWARD the B-ORG Tianjin I-ORG outstanding I-ORG talent I-ORG training I-ORG program I-ORG the I-ORG Tianjin I-ORG Science I-ORG I-ORG Technology I-ORG Planning I-ORG Project I-ORG Grant O 14ZCZDSY00157 B-AWARD and O 15PTCYSY00020 B-AWARD and O Yantai B-ORG Marine I-ORG economy I-ORG innovation I-ORG development I-ORG demonstration I-ORG project I-ORG Grant O YHCX-SW-L-201703 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 81570690 B-AWARD 81873611 I-AWARD and I-AWARD 81700633 O the O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Team I-ORG of I-ORG Henan I-ORG Grant O No. O 17IRTSTHN020 B-AWARD the O Foundation B-ORG for I-ORG Leading I-ORG Personnel I-ORG of I-ORG the I-ORG Central I-ORG Plains I-ORG of I-ORG China I-ORG Grant O No. O 194200510006 B-AWARD and O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2018M642797 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32201320 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2021M693450 O and O the O earmarked B-ORG fund I-ORG for I-ORG Modern I-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG CARS-08 O The O work O was O supported O by O Grant O 078937 B-AWARD from O The B-ORG Wellcome I-ORG Trust O The O authors O gratefully O acknowledge O the O support O by O the O project O LO1509 B-AWARD of O the O Ministry B-ORG of I-ORG Education I-ORG Youth I-ORG and I-ORG Sports I-ORG of I-ORG the I-ORG Czech I-ORG Republic I-ORG and O by O Operational O Program O Prague O – O Competitiveness O project O CZ.2.16/3.1.00/24023 O supported O by O EU. B-ORG This O work O was O supported O by O the O Hungarian B-ORG National I-ORG Research I-ORG Development I-ORG and I-ORG Innovation I-ORG Office I-ORG NKFI O NKFI-137793 B-AWARD and O by O the O European B-ORG Union O co-financed O by O the O European O Social O Fund O EFOP-3.6.1.-16-2016-00004 B-AWARD New B-ORG National I-ORG Excellence I-ORG Program I-ORG of I-ORG the I-ORG Ministry I-ORG for I-ORG Innovation I-ORG and I-ORG Technology O Project O no. O TKP2021-EGA-17 B-AWARD has O been O implemented O with O the O support O provided O by O the O NKFI O This O study O was O supported O by O the B-ORG Small I-ORG Scale I-ORG Characteristic I-ORG Teaching I-ORG Reform I-ORG Project I-ORG of I-ORG Peking I-ORG Union I-ORG Medical I-ORG College I-ORG Hospital I-ORG No. O 2014zlgc0140 I-AWARD and I-AWARD 2104zlgc0136 O to O Hui O Pan O the B-ORG Young I-ORG Teacher I-ORG Training I-ORG Program I-ORG of I-ORG Peking I-ORG Union I-ORG Medical I-ORG College I-ORG No. O 14-2014zlgc0717 O to O Nai-Xin O Liang O and O Teaching O Reform O Project O of O Peking O Union O Medical O College O Hospital O No. O 2014zlgc0135 O to O Nai-Xin O Liang O This O research O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG program I-ORG of I-ORG China I-ORG under O Grant O No. O 2022YFA1200118 B-AWARD China B-ORG National I-ORG Funds I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scientists I-ORG under O Grant O 61825403 B-AWARD The B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grants O 61921005 B-AWARD and O 61674078 B-AWARD and O Nanjing O Scientific O O Technological O Talents O Program O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81788101 O 81622028 B-AWARD 31470813 B-AWARD 1000 O Talents O Plan O Youth O program O to O L.S O CAMS B-ORG Innovation O Fund O for O Medical O Sciences O CIFMS O 2016-I2M-3-020 O Chinese B-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG 2016ZX310192 O 2016RC310037 B-AWARD 2016RC310031 B-AWARD Funding O for O open O access O charge O National O Natural O Science O Foundation O of O China O CAMS O Innovation O Fund O for O Medical O Sciences O NSFC B-ORG 12002390 O 12062018 B-AWARD 12172333 B-AWARD Program B-ORG for I-ORG Young I-ORG Talents I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG in I-ORG Universities I-ORG of I-ORG Inner I-ORG Mongolia I-ORG Autonomous I-ORG Region I-ORG NJYT22075 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Inner I-ORG Mongolia I-ORG 2020MS01015 O Basic B-ORG Science I-ORG Research I-ORG Fund I-ORG in I-ORG the I-ORG Universities I-ORG Directly I-ORG under I-ORG the I-ORG Inner I-ORG Mongolia I-ORG Autonomous I-ORG Region I-ORG JY20220063 O JY20220331 B-AWARD This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81672113 O to O J.L O 31801099 B-AWARD to O Y.Z O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG C2018202083 O to O J.L O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG BMU2017YJ004 O to O Y.Z O The O funding O body O has O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 61504084 B-AWARD the O Basical B-ORG Research I-ORG Program I-ORG of I-ORG Shenzhen I-ORG Grant O No. O JCYJ20160307144047526 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG SZU I-ORG Grant O No. O 201554 B-AWARD Grant O No. O 827-000187 B-AWARD National B-ORG Institute I-ORG of I-ORG Diabetes I-ORG and I-ORG Digestive I-ORG and I-ORG Kidney I-ORG Diseases I-ORG T32 O DK007734 O National B-ORG Institute I-ORG of I-ORG Environmental I-ORG Health I-ORG Sciences I-ORG R01 O ES023485 O U2C B-AWARD ES030163 O and O National B-ORG Institutes I-ORG of I-ORG Health O Office O of O the O Director O S10 O OD018006 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O NO. O 81301912 B-AWARD Beijing B-ORG Municipal I-ORG Health I-ORG System I-ORG High-level I-ORG Health I-ORG Person I-ORG Foundation I-ORG Project I-ORG Grant O NO. O 2014-3-005 B-AWARD and O Beijing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG Capital O Features O Z161100000516083 B-AWARD to O Qin O Li O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 51402198 I-AWARD 21671139 I-AWARD 21201123 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province I-ORG 201602592 O 20170540715 O and O Educational O Bureau O of O Liaoning O Province O for O the O Fundamental B-ORG Research I-ORG of I-ORG Key I-ORG Lab I-ORG LZ2016003 O LQ2017005 I-AWARD L2017LZD002 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31372427 O The B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0501200 O and O Heilongjiang B-ORG Province I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG C2016030 O The O research O was O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFB1104700 O 2018YFB1107202 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 91750205 B-AWARD 61774155 I-AWARD 61705227 O Bill O and O Melinda O Gates O Foundation O of O the O US O OPP1157723 O Scientific B-ORG Research I-ORG Project I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG QYZDB-SSW-SYS038 O Jilin O Provincial O Science O and O Technology O Development O Project O 20180414019GH O and O The O Key O Program O of O the O International O Partnership O Program O of O CAS O 181722KYSB20160015 O R.A.G O thanks O the O financial O support O from O the O Chinese O Academy O of O Sciences O President’s O International O Fellowship O Initiative O Grant O No. O 2018VSA0001 O Funding O and O financial O support O have O been O received O from O STFC B-ORG ST/N005406/1 O BBSRC B-ORG BB/N012690/1 O BB/P00220X/1 O EPSRC B-ORG EP/N013905/1 O EP/P001114/1 O Find O A O Better O Way O SUPA O the O Royal O Society O RS O the O Royal O Society O of O Edinburgh O RSE O NHS O Greater O Glasgow O O Clyde O and O Linn O Products O Ltd O and O the O University O of O the O West O of O Scotland O University O of O Glasgow O and O University O of O Strathclyde O are O gratefully O acknowledged O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82003983 O the O Central B-ORG Public I-ORG Scientific I-ORG Research I-ORG Institution I-ORG Fundamental I-ORG Project I-ORG 2022-JYB-JBZR-003 O and O the O Open B-ORG Project I-ORG of I-ORG Key I-ORG Laboratory I-ORG of I-ORG Molecular I-ORG Pharmacology I-ORG and I-ORG Drug I-ORG Evaluation I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG P202201 O This O work O was O supported O by O grants O from O the O Chinese B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2011CB100100 O the B-ORG China I-ORG Agricultural I-ORG Research I-ORG System I-ORG CARS-3-1-1 O the B-ORG National I-ORG High-Tech I-ORG R I-ORG I-ORG D I-ORG Program I-ORG of I-ORG China I-ORG 2012AA101105 O the B-ORG Six I-ORG Talent I-ORG Peaks I-ORG Project I-ORG in I-ORG Jiangsu I-ORG Province I-ORG 2013NY-049 O and O the B-ORG Key I-ORG R I-ORG I-ORG D I-ORG Program I-ORG in I-ORG Jiangsu I-ORG Province I-ORG BE2015352-3 O This O study O was O supported O by O the O grants O from O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG public I-ORG welfare I-ORG research I-ORG institutes I-ORG No. O ZXKT17049 B-AWARD Beijing B-ORG Nova I-ORG Program I-ORG No. O Z181100006218020 B-AWARD the B-ORG Major I-ORG Science I-ORG and I-ORG Technology I-ORG Programs I-ORG in I-ORG Yunnan I-ORG Province I-ORG No. O 2016ZF001-001 B-AWARD and O the B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Yantai I-ORG No. O 2015ZH071 B-AWARD We O are O funded O by O the O German B-ORG Ministry I-ORG of I-ORG Education I-ORG and I-ORG Research I-ORG BMBF O grants O 01IS18074E B-AWARD 01IS16003B O by O DFG B-ORG grant O MA B-AWARD 5030/3-1 O and O by O the O EU B-ORG EFRE/Thüringer I-ORG Aufbaubank I-ORG TAB O grant O 2015FE9033 B-AWARD The O project O was O supported O by O the O Program O for O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31472300 O http://www.nsfc.gov.cn O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG LY17C190003 O http://www.zjnsf.gov.cn O and O Young B-ORG Talent I-ORG Cultivation I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Association I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG 2016YCGC003 O http://www.zast.org.cn O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O by O Ministry B-ORG of I-ORG Business I-ORG Innovation I-ORG and I-ORG Employment O New O Zealand O MAUX1309 O Singapore-New B-ORG Zealand I-ORG Foods I-ORG for I-ORG Health I-ORG Grant I-ORG BMRC O grant I-AWARD 14/1/16/24/008 O and O the O Mexican B-ORG National I-ORG Council I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG Scholarship O No. I-AWARD 383233 O This O work O was O supported O by O the O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG funding O reference O number O RN304779 B-AWARD O 379428 O Author O AM O the O Campus B-ORG France I-ORG Eiffel O Excellence O Scholarship O 895191H O Author O AM O and O the O Mitacs B-ORG GobaLink O program O IT10648 O Author O AM O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O present O study O was O supported O by O the O Fund B-ORG of I-ORG the I-ORG National I-ORG Nature I-ORG Science I-ORG Foundations I-ORG grant O no. O 81202387 B-AWARD and O the O Sichuan B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG no. O 2013JY0013/2014JY0213 B-AWARD and O the B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Sichuan I-ORG University I-ORG for I-ORG outstanding I-ORG young I-ORG scholars I-ORG no. O 2013SCU04A22 B-AWARD The B-ORG seventh I-ORG new I-ORG century I-ORG education I-ORG reform I-ORG projects I-ORG sponsored I-ORG by I-ORG Sichuan I-ORG University I-ORG no.(SCUY7093 O Demonstration B-ORG project I-ORG of I-ORG Chengdu I-ORG science I-ORG and I-ORG technology I-ORG 2015-HM02-00075-SF O This O work O was O supported O by O theBill O I-ORG Melinda I-ORG Gates I-ORG Foundation I-ORG Seattle I-ORG WA[grant O number O OPP1052535 B-AWARD theUnited O States I-ORG Agency I-ORG for I-ORG International I-ORG Development I-ORG Washington I-ORG D.C.[grant O number O BFS-G-11-00002 B-AWARD and O theUnited O States I-ORG Borlaug I-ORG Fellows I-ORG in I-ORG Global I-ORG Food I-ORG Security I-ORG Awarded I-ORG to I-ORG Purdue I-ORG University I-ORG Washington I-ORG D.C.[grant O number O A11023.2 B-AWARD This O work O was O supported O by O the B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Province I-ORG No.1708085MH230 O and O the B-ORG Nature I-ORG Science I-ORG Key I-ORG Program I-ORG of I-ORG College I-ORG and I-ORG University I-ORG of I-ORG Anhui I-ORG Province I-ORG No.KJ2015A269 O and O KJ2016A488 B-AWARD and O Key B-ORG projects I-ORG of I-ORG support I-ORG program I-ORG for I-ORG outstanding I-ORG young I-ORG talents I-ORG in I-ORG Colleges I-ORG and I-ORG Universities I-ORG of I-ORG Anhui I-ORG Province I-ORG No. O gxyqZD2016160 O This O work O was O partly O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Programs I-ORG of I-ORG China I-ORG No. O 2017YFC1200201 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81741062 B-AWARD and O 31572525 O Jiangsu B-ORG Provincial I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Projects I-ORG No. O BE2017693 B-AWARD Projects B-ORG of I-ORG the I-ORG State I-ORG Forestry I-ORG Administration I-ORG No.2130211 O and O Blood O Systems O Research O Institute O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31770322 O to O S.Y O the O Project O of O Sichuan B-ORG Province I-ORG Youth I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Team I-ORG 20CXTD0062 O to O S.Y O and O the O Applied B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG Sichuan I-ORG Province I-ORG 20YYJC4388 O to O Z.-W.Z O MWS O would O like O to O acknowledge O the O support O of O the O Canadian O Institutes O of O Health O Research O CIHR O and O Scottish O Rite O Charitable O Foundation O HC O is O supported O by O grant O R01 B-AWARD MH094400 O Creation O of O DNA O and O cell O lines O was O supported O by O the O National B-ORG Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences I-ORG of O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG under O Award O Number O 1ULTR001067 B-AWARD The O project O described O was O supported O by O Award O Number O P30CA042014 B-AWARD from O the O National B-ORG Cancer I-ORG Institute I-ORG The O authors O would O like O to O acknowledge O FAPESP B-ORG 2017/10728-2 O 2018/06475-4 B-AWARD 2018/07707-6 B-AWARD 2018/05421-8 B-AWARD Capes B-ORG Finance O code O 001 B-AWARD and O CNPq B-ORG 301436/2017-7 O 308569/2018-0 B-AWARD for O their O financial O support O This O project O has O been O funded O in O whole O or O in O part O with O Federal O funds O from O the O National B-ORG Cancer I-ORG Institute O National O Institutes O of O Health O under O Contract O No. O HHSN261200800001E B-AWARD The O content O of O this O publication O does O not O necessarily O reflect O the O views O or O policies O of O the O Department O of O Health O and O Human O Services O nor O does O mention O of O trade O names O commercial O products O or O organizations O imply O endorsement O by O the O U.S O Government O Additionally O we O acknowledge O supplementary O funds O from O the O Delaney B-ORG AIDS I-ORG Research I-ORG Enterprise I-ORG to O Defeat O HIV O DARE O collaboratory O funded O by O NIAID O NIH O U19 O AI096109 O VV O is O supported O by O a O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG of O Australia O Career O Development O Fellowship O 1067590 O MPD O is O supported O by O an O NHMRC O Senior O Research O Fellowship O 1080001 O and O Program O Grant O 1052979 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O is O supported O by O the O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Fund I-ORG of I-ORG Henan I-ORG Agricultural I-ORG University I-ORG KJCX2019A10 O Earmarked B-ORG Fund I-ORG for O China O Agriculture O Research O System O NO. O CARS-27 O Key B-ORG Scientific I-ORG Research I-ORG Projects I-ORG of I-ORG Henan I-ORG Province I-ORG Grant O Nos O 16A210029 B-AWARD 18B210006 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O financially O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFC1601704 B-AWARD 2018YFC1604202 O 2018YFC160015 O 2017YFC1601806 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31601552 O 21603087 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O BK20160178 B-AWARD Forestry O Science O and O Technology O Innovation O and O Extension O Project O of O Jiangsu O Province O No. O LYKJ O 2017 O 26) O and O the O National O First-class O Discipline O Program O of O Food O Science O and O Technology O JUFSTR20180509 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51706063 O Young B-ORG Key I-ORG Teachers I-ORG Training I-ORG Program I-ORG of I-ORG Henan I-ORG Higher I-ORG Education I-ORG Institutions I-ORG 2018GGJS028];Henan O Youth I-ORG Talent I-ORG Project I-ORG 2019HYTP026 O This O work O was O supported O by O National B-ORG Health I-ORG Research I-ORG Institutes I-ORG of I-ORG Taiwan I-ORG NHRI-105A1-PDCO-0316164 O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Taiwan I-ORG MOST104-2221-E-037-001-MY3 O MOST104-2320-B-037-032-MY2 O Kaohsiung B-ORG Medical I-ORG University I-ORG Research I-ORG Foundation I-ORG KMU-M104010 O NSYSU-KMU B-ORG Joint I-ORG Research I-ORG Project I-ORG NSYSUKMU105-I007 O and O Center B-ORG of I-ORG Excellence I-ORG for I-ORG Environmental I-ORG Medicine I-ORG KMU-TP104A25 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O material O is O based O upon O work O funded O by O the O Nature O and O Science O Foundation O of O China O Grant O No. O 81570869 O Nature O and O Science O Foundation O of O Zhejiang O Province O China O Grant O No. O Y2110784 O Zhejiang B-ORG Provincial I-ORG Foundation I-ORG of I-ORG China I-ORG for I-ORG Distinguished I-ORG Young I-ORG Talents I-ORG in I-ORG Medicine I-ORG and I-ORG Health I-ORG Grant O No. B-AWARD 2010QNA018 O Foundation B-ORG of I-ORG Wenzhou I-ORG City I-ORG Science I-ORG I-ORG Technology I-ORG Bureau I-ORG Grant O No. B-AWARD Y20140705 O and O Engineering B-ORG Development I-ORG Project I-ORG of I-ORG Ophthalmology I-ORG and I-ORG Optometry I-ORG Grant O No. B-AWARD GCKF201601 O The O funding O sources O were O not O involved O in O study O design O in O the O collection O analysis O and O interpretation O of O data O in O the O writing O of O the O report O or O in O the O decision O to O submit O the O article O for O publication O This O research O was O funded O by O the O Guizhou B-ORG domestic I-ORG first-class I-ORG construction I-ORG project I-ORG (Chinese B-AWARD Materia I-AWARD Medica I-AWARD GNYL I-AWARD 2017 I-AWARD 008 O Guizhou B-ORG Province I-ORG Miao I-ORG Medicine I-ORG key I-ORG Laboratory I-ORG Project I-ORG Qianmiao B-AWARD medicine I-AWARD K I-AWARD Zi I-AWARD 2017 I-AWARD 027 O and O Miao B-ORG Nationality I-ORG Medicine I-ORG Research I-ORG Synergy I-ORG Innovation I-ORG Center I-ORG Project I-ORG Grant B-AWARD No. I-AWARD Qian I-AWARD Jiao I-AWARD He I-AWARD Xie I-AWARD Tong I-AWARD Chuang I-AWARD Xin I-AWARD Zi I-AWARD 2015 I-AWARD 05th I-AWARD The O funding O bodies O play O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O Funding O for O the O TEMPER O study O was O provided O by O Cancer B-ORG Research I-ORG UK I-ORG grant O C1495/A13305 B-AWARD from O the O Population O Research O Committee O with O additional O support O from O the O Medical B-ORG Research I-ORG Council I-ORG MC_EX_UU_G0800814 O and O the O MRC B-ORG London I-ORG Hub I-ORG for I-ORG Trial I-ORG Methodology I-ORG Research I-ORG MC_UU_12023/24 O This O study O was O supported O by O the O Japan B-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG 22K16009 O to O YS, O 18H02788 O to O TA, O 26670322 O to O AT, O and O 17K11661 O to O Kiminori O N]; O Japan B-ORG Science I-ORG and I-ORG Technology I-ORG Agency I-ORG JPMJCE O 1301 I-AWARD to O TA, O AT, O and O Kiminori O N, O JPMJPF2108 O to O AT O and O Kiminori O N]; O Ministry B-ORG of I-ORG Agriculture I-ORG Forestry I-ORG and I-ORG Fisheries O Japan O 14538261 O to O AT O the O Japan B-ORG Foundation I-ORG for I-ORG Aging I-ORG and I-ORG Health I-ORG 2015-58-2 O to O SU O and O the O Mitsubishi B-ORG Foundation I-ORG 10492 O to O AT O This O work O was O supported O by O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U1805231 O 31602046 B-AWARD and O 31302050 B-AWARD the O FAFU B-ORG Program I-ORG for I-ORG Promising I-ORG Academic I-ORG Youngsters O 2014 O and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0500205 B-AWARD This O study O was O supported O by O the O Technology B-ORG Commission I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2013B020304002 O Foundation B-ORG of I-ORG Young I-ORG Creative I-ORG Talents I-ORG in I-ORG Higher I-ORG Education I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017KQNCX020 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31572089 O and O Modern B-ORG Agricultural I-ORG Industry I-ORG Technology I-ORG System I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2016LM1128 O The O funders O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O Data O collection O and O analysis O and O interpretation O are O supported O by O NSF B-ORG China I-ORG 31771580 O and I-AWARD 81702795 O Department B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2017FZ0034 O and O 2019JDTD0020 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2018NZD17 O and O Academic O and O Technology O Leader O Foundation O of O Sichuan O Province O [2016 O 183–29 O Study O design O and O writing O is O supported O by O NSF31771580 O and O intramural O funding O of O West O China O Second O University O Hospital O During O the O whole O course O process O the O study O design O reagent O purchase O and O clinical O data O collection O are O mainly O supported O by O the O “Eastern O Scholar” O Fund O and O the O “Guangxi O Bagui O Scholar” O fund O Data O analysis O and O data O interpretation O of O Whole O Exome O Sequencing O are O mainly O supported O by O National B-ORG key I-ORG research I-ORG and I-ORG development I-ORG program I-ORG 2018YFC1002501 O and O the B-ORG Major I-ORG Research I-ORG Plan I-ORG of I-ORG the I-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Foundation I-ORG of I-ORG Guangxi I-ORG Grant O No.AB16380214 O Manuscript O preparation O is O supported O by O “YUMIAOJIHUA” B-ORG Project I-ORG of I-ORG The I-ORG Maternal I-ORG I-ORG Child I-ORG Health I-ORG Hospital I-ORG of I-ORG Guangxi I-ORG Zhuang I-ORG Autonomous I-ORG Region I-ORG GXWCH-YMJH-2017005 O This O work O was O supported O by O the O National B-ORG Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases O the O National O Institutes O of O Health O NIH O grant O number O UM1AI069465 B-AWARD PIs O Flexner O and O Gupta O for O the O BWI O CTU O for O Byramjee O Jeejeebhoy O Government O Medical O College O HIV O Clinical O Trials O Site O Additional O support O was O provided O by O Fogarty B-ORG International I-ORG Center O NIH O grant O number1D43TW009574 O PI: O Robert O Bollinger O It O is O also O supported O by O NIH B-ORG Eunice I-ORG Kennedy I-ORG Shriver I-ORG National I-ORG Institute I-ORG of I-ORG Child I-ORG Health I-ORG I-ORG Human I-ORG Development I-ORG Foundation I-ORG for I-ORG AIDS I-ORG Research I-ORG amfAR O supported O by O funds O from O the O US O National O Institutes O of O Health O NIH O for O contributions O to O the O International O Epidemiologic O Databases O to O Evaluate O AIDS O IeDEA O a O project O of O the O NIH O National O Institutes O of O Allergy O and O Infectious O Diseases O NIAID O U01AI069907 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31972540 B-AWARD the O Project B-ORG of I-ORG Swine I-ORG Innovation I-ORG Team I-ORG in I-ORG Guangdong I-ORG Modern I-ORG Agricultural I-ORG Research I-ORG System I-ORG 2019KJ26 O and O the O Pearl B-ORG River I-ORG Nova I-ORG Program I-ORG of I-ORG Guangzhou I-ORG Grant O No. O 201906010011 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31702087 O 31672391 I-AWARD 31701144 O the O Key B-ORG project I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31790414 O and O the O National B-ORG Swine I-ORG Industry I-ORG Technology I-ORG System I-ORG CARS-35 O This O work O was O supported O by O the B-ORG German I-ORG Federal I-ORG Ministry I-ORG of I-ORG Education I-ORG and I-ORG Research I-ORG BMBF O under O the O grant O 01GY1141 O and O by O the O Research B-ORG Council I-ORG of I-ORG Norway I-ORG grant O no. O 190756 B-AWARD Directorate B-ORG for I-ORG Health I-ORG and I-ORG Social I-ORG Affairs I-ORG the I-ORG Norwegian I-ORG Dam I-ORG Foundation I-ORG grant O no. O 2008/2/0306 B-AWARD and O the O Norwegian O Center O for O Violence O and O Traumatic O Stress O Studies O This O work O was O supported O by O The B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG of I-ORG the I-ORG 13th I-ORG Five-Year I-ORG Plan I-ORG No.2016YFC1306205 O the B-ORG provincial I-ORG key I-ORG disciplines I-ORG of I-ORG Zhejiang I-ORG traditional I-ORG Chinese I-ORG medcine I-ORG combination O of O traditional O Chinese O and O Western O medicine O No.2017-XK-A41 O Technological B-ORG Research I-ORG Program I-ORG of I-ORG Zhejiang I-ORG 2015C33178 O made O contributions O to O the O design O of O the O study O data O collection O and O analysis O This O study O was O funded O by O the B-ORG State I-ORG Key I-ORG Project I-ORG on I-ORG Infection I-ORG Disease I-ORG of I-ORG China I-ORG No. O 2018ZX10723204-003 O the B-ORG Chinese I-ORG Ministry I-ORG of I-ORG Public I-ORG Health I-ORG for I-ORG Key I-ORG Clinical I-ORG Project I-ORG No. O 2010 I-AWARD 493-51 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81502530 O 81874189 B-AWARD and O 81874149 B-AWARD Student B-ORG innovation I-ORG project I-ORG of I-ORG Huazhong I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2019A0020 O This O study O was O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG No. O LY17H030008 B-AWARD the O joint O construction O of O projects O by O provinces O and O the O ministry O of O education O No. O 2014PYA002 O Traditional B-ORG Chinese I-ORG Medicine I-ORG Research I-ORG Project I-ORG of I-ORG Zhejiang I-ORG No.2020ZB009 O and O Medical B-ORG and I-ORG Health I-ORG research I-ORG fund I-ORG project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. O 2017KY190 B-AWARD This O work O was O supported O by O grants O 31472268 B-AWARD and O 31502147 B-AWARD from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O 2016FBZ05 B-AWARD from O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Freshwater I-ORG Ecology I-ORG and I-ORG Biotechnology O grant O XDJK2018B025 B-AWARD from O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Ministry O of O Education O of O China O The O funding O body O didn’t O play O any O roles O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O FundingThis O work O was O supported O by O the O following O projects O 1. O Inner B-ORG Mongolia I-ORG Autonomous I-ORG Region I-ORG Natural I-ORG Science I-ORG Fund I-ORG Project O No. O 2018LH03003 B-AWARD 2. O Scientific B-ORG research I-ORG project I-ORG of I-ORG institutions I-ORG of I-ORG higher I-ORG learning I-ORG in I-ORG Inner I-ORG Mongolia I-ORG autonomous I-ORG region O No. O NJZZ18203 B-AWARD 3. O Major B-ORG science I-ORG and I-ORG technology I-ORG projects I-ORG of I-ORG Inner I-ORG Mongolia I-ORG autonomous I-ORG region O No. O ZDZX2018009 B-AWARD This O study O was O financially O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81670957 B-AWARD 81700938 B-AWARD and O 81772876 B-AWARD seed O grants O from O the O PKU B-ORG School I-ORG of I-ORG Stomatology I-ORG for I-ORG PostDoc I-ORG YS0203 O a O grant O of O Peking B-ORG University I-ORG School I-ORG and I-ORG Hospital I-ORG of I-ORG Stomatology I-ORG PKUSS20140104 O and O the O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 7172239 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O theBill O I-ORG Melinda I-ORG Gates I-ORG FoundationGrant O 51251 B-AWARD www.gatesfoundation.org O theWellcome O TrustGrant O 086546 B-AWARD www.wellcome.ac.uk O theUS O National I-ORG Institutes I-ORG of I-ORG Health I-ORG NIH)grant O R03AI092121 B-AWARD and O theNIH O Early I-ORG IndependenceAward O grant O 1DP5OD009162 B-AWARD Office O of O the O Director O and O the O National O Institute O of O Dental O and O Craniofacial O Research O www.nih.gov O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81201328 B-AWARD the O Fujian B-ORG Provincial I-ORG Funds I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scientists I-ORG in I-ORG Colleges I-ORG and I-ORG Universities I-ORG China I-ORG Grant O No. O JA13134 B-AWARD and O the O Medical B-ORG Elite I-ORG Cultivation I-ORG Program I-ORG of I-ORG Fujian I-ORG China I-ORG Grant O No. O 2015-ZQN-ZD-15 B-AWARD This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81673023 O 81872501 B-AWARD 81502068 B-AWARD Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 7172177 O and O the O Nonprofit B-ORG Central I-ORG Research I-ORG Institute I-ORG Fund I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG 2018PT32014 O G.B O was O supported O by O grants O from O LOTO B-ORG Onlus I-ORG Italy O CF B-AWARD 91359630372 O The O research O was O partially O funded O by O a O grant O awarded O by O Fondazione B-ORG del I-ORG Monte I-ORG di I-ORG Bologna I-ORG e I-ORG Ravenna I-ORG ID O ROL:FDM/3107 B-AWARD Prot I-AWARD 534bis/2014 O and O by O a O grant O awarded O by O Fondazione B-ORG Cassa I-ORG di I-ORG Risparmio I-ORG in I-ORG Bologna I-ORG 2020_19078 O to O D.T O This O research O was O funded O by O Consejo B-ORG Nacional I-ORG de I-ORG Ciencia I-ORG y I-ORG Tecnología I-ORG CONACYT I-ORG México O Grants O Numbers O A1-S-7495 B-AWARD by O Programa B-ORG de I-ORG Apoyo I-ORG a I-ORG Proyectos I-ORG de I-ORG Investigación I-ORG e I-ORG Innovación I-ORG Tecnológica I-ORG PAPIIT O Grant O Numbers O IN202219 B-AWARD and O IN200922 B-AWARD of O the O Universidad O Nacional O Autónoma O de O México O UNAM O and O by O Programa B-ORG de I-ORG Apoyo I-ORG a I-ORG la I-ORG Investigación I-ORG y I-ORG el I-ORG Posgrado I-ORG PAIP O Grant O Number O 5000-9105 B-AWARD This O work O was O supported O by O Technology B-ORG Program I-ORG of I-ORG Gansu I-ORG Province I-ORG Grant O No. O 1604FKCA110 B-AWARD Grant O No. O 1606RJZA087 B-AWARD and O Grant O No. O 1610RJZA060 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG China I-ORG Grant O No. O lzujbky-2017-197 B-AWARD the O Project B-ORG of I-ORG Lanzhou I-ORG City I-ORG for I-ORG Innovative I-ORG and I-ORG Entrepreneurial I-ORG Talents I-ORG Grant O No. O 2017-RC-73 B-AWARD and O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Lanzhou I-ORG City I-ORG Grant O No. O 2015-3-93 B-AWARD Grant O No. O 2016-3-75 B-AWARD and O Grant O No. O 2017-4-122 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O numbers O 51708429 B-AWARD the O Open B-ORG Projects I-ORG Foundation I-ORG of I-ORG Engineering I-ORG Research I-ORG Center I-ORG of I-ORG Disaster I-ORG Prevention I-ORG and I-ORG Mitigation I-ORG of I-ORG Southeast I-ORG Coastal I-ORG Engineering I-ORG Structures I-ORG of I-ORG Fujian I-ORG Province I-ORG University O grant O number O 2022009 B-AWARD and O the O Plan B-ORG of I-ORG Outstanding I-ORG Young I-ORG and I-ORG Middle-aged I-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG Team I-ORG in I-ORG Universities I-ORG of I-ORG Hubei I-ORG Province O grant O number O T2020010 B-AWARD This O work O was O supported O by O the O Basic O Science O Research O Program O Grant O No. O 2014R1A1A2058183 B-AWARD 2018R1D1A1B07048696 B-AWARD 2019R1A2C2084122 O and O MRC O grant O 2018R1A5A2020732 O through O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O funded O by O the O Ministry O of O Science O O ICT O MSIT O by O the O Ministry B-ORG of I-ORG Trade I-ORG Industry I-ORG and I-ORG Energy I-ORG under O the O Industrial O Technology O Innovation O Program O 10080726 O 20000843 B-AWARD and O by O the O Ministry B-ORG of I-ORG Health I-ORG and I-ORG Welfare O Republic O of O Korea O HI18C2391 O This O work O was O supported O by O grants O 2018-775 O from O the O Asan B-ORG Institute I-ORG for I-ORG Life I-ORG Sciences O Asan O Medical O Center O Seoul O Korea O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81960054 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Province I-ORG 20192BAB205010 O and O the O Technological B-ORG Project I-ORG of I-ORG Health I-ORG Commission I-ORG of I-ORG Jiangxi I-ORG Province I-ORG 20195128 O The O funders O had O no O role O in O the O design O or O execution O of O this O study O The O Australian B-ORG Research I-ORG Council I-ORG Discovery O grant O DP120104146 B-AWARD awarded O to O JSK O and O SCD O supported O the O sequencing O work O P.Y.N O acknowledges O postdoctoral O fellowship O from O The B-ORG Research I-ORG Foundation I-ORG – I-ORG Flanders I-ORG FWO O 12S9618N B-AWARD This O work O was O also O supported O by O the O European B-ORG Research I-ORG Council I-ORG ERC O under O the O European O Union’s O Horizon O 2020 O research O and O innovation O programme O grant O number O ERC-StG B-AWARD 679056 I-AWARD HOTSPOT O via O a O grant O to O L.Y O YVdP O acknowledges O funding O from O the O European O Research O Council O ERC O under O the O European O Union’s O Horizon O 2020 O research O and O innovation O program O grant O agreement O No O 833522 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31372024 O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-30 O and O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG CAAS-ASTIP-2015-ZFRI O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81970980 B-AWARD Liaoning B-ORG Province I-ORG Colleges I-ORG and I-ORG Universities I-ORG Basic I-ORG Research I-ORG Project I-ORG No. O LFWK201717 B-AWARD Liaoning B-ORG Provincial I-ORG Key I-ORG Research I-ORG Plan I-ORG Guidance I-ORG Project I-ORG No. O 2018225078 B-AWARD Liaoning B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Guidance I-ORG Project I-ORG No. O 2019-ZD-0749 B-AWARD Shenyang B-ORG Major I-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG No. O 19-112-4-027 B-AWARD Shenyang B-ORG Young I-ORG and I-ORG Middle-aged I-ORG Technological I-ORG Innovation I-ORG Talent I-ORG Plan I-ORG No. O RC200060 O Shenyang B-ORG National I-ORG Laboratory I-ORG for I-ORG Materials I-ORG Science I-ORG No. O 2015RP04 O the O Second O Batch O of O Medical B-ORG Education I-ORG Scientific I-ORG Research I-ORG Projects I-ORG of O the O 13th O Five-Year O Plan O of O China O Medical O University O No. O YDJK2018017 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Supported O in O part O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG for I-ORG Young I-ORG Scholars I-ORG Grant O No. O 81600762(Jing B-AWARD Zhao O the O National O Natural O Science O Foundation O of O China O Grant O No. O 81570879 B-AWARD O 81770955(Xingtao B-AWARD Zhou O and O the O Project B-ORG of I-ORG Shanghai I-ORG Science I-ORG and I-ORG Technology O Grant O No O 17140902900 O O 17411950201(Xingtao B-AWARD Zhou O The O funders O have O no O financial O orproprietary O interest O in O the O materials O and O products O presented O herein O This O article O presents O independent O research O funded O by O the O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG NIHR O under O its O Research O for O Patient O Benefit O programme O Grant O number O PB-PG-0110-21342 B-AWARD The O views O expressed O are O those O of O the O author(s O and O not O necessarily O those O of O the O NHS O the O NIHR O or O the O Department O of O Health O It O was O also O supported O by O Genesis B-ORG Breast I-ORG Cancer I-ORG Prevention I-ORG Grant O number O GA09-001/GA10-002 B-AWARD DGE O EFH O SA O and O AH O are O supported O by O the O NIHR O Manchester O Biomedical O Research O Centre O IS-BRC-1215-20007 O DGE O is O an O NIHR O senior O investigator O ARB O and O JC O were O supported O by O Cancer B-ORG Research I-ORG UK I-ORG Grant O number O C569/A16891 B-AWARD Funders O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O or O in O writing O the O manuscript O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 81601427 B-AWARD and O 81671612 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG grant O numbers O 2016A030313307 B-AWARD 2017A030313470 B-AWARD and O 2017A030313576 B-AWARD State O Scholarship O Fund O from O China B-ORG Scholarship I-ORG Council I-ORG file O number O 201806385034 B-AWARD and O Yat-Sen O Scholarship O for O Young O Scientists O to O Mo O YQ O The O work O was O sponsored O by O the O National B-ORG Key I-ORG Sci-Tech I-ORG Special I-ORG Project I-ORG of I-ORG China I-ORG No. O 2018ZX10302207 B-AWARD the O Beijing B-ORG Hospitals I-ORG Authority I-ORG Incubating I-ORG Program I-ORG PX2018060 O and O the O Beijing B-ORG Hospitals I-ORG Authority I-ORG Youth I-ORG Programme I-ORG QML20181803 O This O research O was O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG NO. O 2018YFA0903000 I-AWARD 2020YFC2005405 I-AWARD 2020YFA0712100 I-AWARD 2020YFC0840805 O Funds O for O First-class B-ORG Discipline I-ORG Construction I-ORG NO. O XK1805 I-AWARD NO. I-AWARD XK1803-06 O Inner B-ORG Mongolia I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG NO. O 2019ZD006 O NSFC-MFST B-ORG project I-ORG China-Mongolia O NO. O 31961143024 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG Central I-ORG Universities I-ORG NO. O BUCTRC201917 I-AWARD BUCTZY2022 O Innovation O O Transfer O Fund O of O Peking O University O Third O Hospital O BYSYZHKC2022114 O Financial O support O was O provided O by O competitive O grants O 25922-N B-AWARD and O 61710 B-AWARD awarded O to O J.F.O B-ORG from O Consejo O Nacional O de O Ciencia O y O Tecnología O CONACyT O and O by O the O Departamento O de O Biología O Evolutiva O INECOL B-ORG to I-ORG J.F.O I-ORG 20030/10563 O R.A.J O was O supported O by O a O Master B-ORG of I-ORG Science I-ORG scholarship I-ORG 261227 O and O a O mixed O scholarship O from O CONACyT O and O by O a O scholarship O from O INECOL O Programa O de O Becas O de O Fomento O al O Incremento O de O la O Productividad O Acadímica O Secretaría O de O Posgrado O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81360404,http://www.nsfc.gov.cn O Guangxi B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 0832013,http://gxnsf.gxsti.net/stms/login.jsp O Innovation B-ORG Project I-ORG of I-ORG Guangxi I-ORG Graduate I-ORG Education I-ORG 201010598RY10 O funding O receiver O XLN O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81374063 O the O Science B-ORG and I-ORG Technology I-ORG Foundation I-ORG of I-ORG Guizhou I-ORG Province I-ORG 2010-C-527 O 2011-5086 B-AWARD and O Key B-ORG Laboratory I-ORG Special I-ORG Development I-ORG Program I-ORG of I-ORG Qinghai I-ORG Province I-ORG 2014-Z-Y02 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Brazilian B-ORG Research I-ORG Council I-ORG CNPq O through O a O ”Science O without O Borders“ O scholarship O grant O number O 201873/2014-1 B-AWARD and O the O European B-ORG Research I-ORG Council I-ORG grant O ERC-2014-STG-638333 B-AWARD to O M.E.B O J.H O and O G.B O received O support O from O the O French B-ORG excellence I-ORG projects I-ORG Labex I-ORG CEBA O ANR-10-LABX-25-01 O and O Labex B-ORG TULIP I-ORG ANR-10-LABX-0041 O This O work O was O performed O within O the O framework O of O the O PhyloAlps O project O whose O sequencing O was O funded O by O France B-ORG Génomique I-ORG ANR-10-INBS-09-08 O P.A.C O is O funded O by O a O Royal B-ORG Society I-ORG University I-ORG Research I-ORG Fellowship I-ORG URF120119 O M.R.M O was O supported O by O NSF B-ORG grant O DEB-11456884 B-AWARD M.R.D O by O Dimensions B-ORG NASA I-ORG grant O DEB-1342782 B-AWARD and O DEB-1457748 B-AWARD to O E.A.K O S.L O received O funding O from O the O LabexOSUG@2020 B-ORG ANR10 O LABX56 O and O the O project O Origin-Alps B-ORG ANR-16-CE93-0004 O Any O opinions O findings O and O conclusions O or O recommendations O expressed O in O this O material O are O those O of O the O authors O and O do O not O necessarily O reflect O the O views O of O the O National O Science O Foundation O This O work O was O supported O by O the O Basic O Science O Research O Capacity O Enhancement O Project O through O Korea B-ORG Basic I-ORG Science I-ORG Institute I-ORG National O Research O Facilities O and O Equipment O Center O grant O funded O by O the O Ministry B-ORG of I-ORG Education I-ORG grant O No. O 2021R1A6C101A432 B-AWARD Bio O O Medical O Technology O Development O Program O of O the O National O Research O Foundation O NRF O O funded O by O the O Korean B-ORG government I-ORG MSIT O grant O No. O 2020M3A9E4104384 B-AWARD and O the O National O Research O Foundation O of O Korea O NRF O grant O funded O by O the O Ministry O of O Education O No. O 2022R1A2C1092597 B-AWARD This O research O was O partially O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2019YFC1711701 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U1913216 O 61803364 B-AWARD U1713219 B-AWARD and O Shenzhen B-ORG Fundamental I-ORG Research I-ORG Project I-ORG JCYJ20180302145549896 O This O work O was O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG OCE-1155290 O and O EAR-1151682 B-AWARD to O C.S.C O and O OCE-1558738 B-AWARD and O MGG B-AWARD OCE-1558712 I-AWARD to O G.W.L O the O National B-ORG Aeronautics I-ORG and I-ORG Space I-ORG Administration I-ORG Exobiology O NNX12AG20G B-AWARD to O C.S.C O D.E O and O G.W.L O and O NNX15AM11G B-AWARD to O D.E O the O Office B-ORG of I-ORG Naval I-ORG Research I-ORG N00014-17-1-2640 O to O C.S.C O and O N00014-17-1-2641 B-AWARD to O D.E O the O USDA O National B-ORG Institute I-ORG of I-ORG Food I-ORG and I-ORG Agriculture I-ORG Agriculture O and O Food O Research O Initiative O grant O number O 2012-68003-30155 B-AWARD to O R.M.M O and O the O University B-ORG of I-ORG Delaware I-ORG Doctoral O Dissertation O Fellowship O to O S.M.M O Computational O infrastructure O support O by O the O University O of O Delaware O CBCB O Core O Facility O funded O by O Delaware O INBRE O grant O number O NIH B-AWARD P20 I-AWARD GM103446 O and O the O Delaware O Biotechnology O Institute O This O work O was O supported O by O the O Transgenic B-ORG Project I-ORG from I-ORG the I-ORG Ministry I-ORG of I-ORG Agriculture I-ORG 2014ZX08009-051B O to O JL O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81370151 O and O 81570046 B-AWARD to O DG, O 31701185 B-AWARD to O HQ O and O 81700054 B-AWARD to O YZ O the O Shenzhen B-ORG Municipal I-ORG Basic I-ORG Research I-ORG Program I-ORG JCYJ20150729104027220 O to O DG O and O JCYJ20160520174217859 B-AWARD to O HQ O Shenzhen B-ORG University I-ORG Interdisciplinary I-ORG Innovation I-ORG Team I-ORG Project I-ORG 000003 O to O DG O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017A030310450 O to O HQ O Research B-ORG Project I-ORG of I-ORG Shenzhen I-ORG Technology I-ORG University I-ORG 201731 O to O HQ O This O work O was O financially O supported O in O part O by O grants O from O the B-ORG Central I-ORG Government I-ORG guided I-ORG Local I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Funds I-ORG 2023ZY1016 O the B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2021C02009 O and O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 31900395 O 32001456 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O grant O GM088274 B-AWARD to O JDW O from O the O U.S O National B-ORG Institutes I-ORG of I-ORG Health I-ORG General O Medical O Sciences O and O grant O IOS–1126998 B-AWARD to O KLC O from O the O U.S O National B-ORG Science I-ORG Foundation O Additional O support O came O from O Grant O DE-FG02-91ER20021 B-AWARD to O the O Plant O Research O Laboratory O from O the O Division O of O Chemical O Sciences O Geosciences O and O Biosciences O Office O of O Basic O Energy O Sciences O U.S B-ORG Department I-ORG of I-ORG Energy I-ORG The O following O funding O was O received O from O the O National B-ORG Research I-ORG Development I-ORG and I-ORG Innovation I-ORG Office O Hungary O grants O NNE-129617 B-AWARD to O M.A.D O K-124922 B-AWARD to O A.D O PD-143268 B-AWARD to O A.K O F.R.W O was O supported O by O the O grant O SA-111/2021 B-AWARD from O Loránd B-ORG Eötvös I-ORG Research I-ORG Network O Hungary O J.S.J O was O supported O by O the O National B-ORG Science I-ORG Technology I-ORG Council I-ORG Taiwan O NSTC107-2923-M-006-002-MY3 B-AWARD JWQ O was O supported O by O Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Committee I-ORG JCYJ20170307161326613 O and O General B-ORG Research I-ORG Fund I-ORG of I-ORG Hong I-ORG Kong I-ORG HKBU O 12301415 O HH O was O supported O by O China O and O Agencia B-ORG Nacional I-ORG de I-ORG Promoción I-ORG Científica I-ORG y I-ORG Tecnológica O Argentina O 0850 O and I-AWARD 0122 O JCHI O received O a O PhD O studentship O from O Hong O Kong O Baptist O University O BVB O was O supported O by O a O postdoctoral O fellowship O of O the O FWO O Vlaanderen O 12N3915N O and O a O grant O from O the O French O Agence O Nationale O de O la O Recherche O ANR-JCJC-EVOLINK O This O study O was O supported O by O the O Foundation O from O Jiangsu B-ORG University I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Clinical I-ORG Medicine I-ORG major O project O Grant O No. O JLY20180013 B-AWARD Wuxi B-ORG Youth I-ORG Projection I-ORG of I-ORG Health I-ORG and I-ORG family I-ORG planning I-ORG commission I-ORG No. O Q201756 B-AWARD Wuxi B-ORG Scientific I-ORG and I-ORG Technological I-ORG Development I-ORG of I-ORG Medical I-ORG and I-ORG Health I-ORG Guidance I-ORG Programs I-ORG No. O NZ2019014 B-AWARD and O Kunshan B-ORG Major I-ORG Project I-ORG of I-ORG Social I-ORG Research I-ORG and I-ORG Development I-ORG No. O KS19038 B-AWARD This O study O was O supported O by O grants O from O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo—Fapesp I-ORG 2011/02746-4 O and I-AWARD 2012/17626-2 O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico—CNPq I-ORG 471382/2011-6 O and O the O European B-ORG Research I-ORG Council I-ORG iPlasticity O 322742 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O manuscript O was O supported O in O part O by O the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 863 O Program O of O China O under O Grant O No. O 2015AA015701 B-AWARD to O XD, O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Jilin I-ORG Province I-ORG under O Grant O No. O 20150204081GX B-AWARD to O XD, O the O 13th B-ORG Five-Year I-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Project I-ORG of I-ORG the I-ORG Education I-ORG Department I-ORG of I-ORG Jilin I-ORG Province I-ORG under O Grant O No. O 2016-378 B-AWARD to O HQ O and O the O Industrial B-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG Jilin I-ORG Province I-ORG Development I-ORG and I-ORG Reform I-ORG Commission I-ORG under O Grant O No. O 2014Y113 B-AWARD to O XD. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-15 O Core B-ORG Research I-ORG Budget I-ORG of I-ORG the I-ORG Non-profit I-ORG Governmental I-ORG Research I-ORG Institution I-ORG 1610172014003 O and O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG CAAS-ASTIP-2013-OCRI O This O research O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG NingXia I-ORG Hui I-ORG Autonomous I-ORG Region I-ORG 2021AAC03185 O the O Research B-ORG Startup I-ORG Foundation I-ORG of I-ORG North I-ORG Minzu I-ORG University I-ORG 2020KYQD23 O the O First-Class B-ORG Disciplines I-ORG Foundation I-ORG of I-ORG NingXia I-ORG Grant O No. O NXYLXK2017B09 B-AWARD and O the O Major B-ORG Project I-ORG of I-ORG North I-ORG Minzu I-ORG University I-ORG 2019MS003 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG NO.2021YFB3200201 O Youth B-ORG Foundation I-ORG of I-ORG Fujian I-ORG Natural I-ORG Science I-ORG NO.2021J05174 O Foshan B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG 2018IT100252 O This O work O was O supported O by O aWellcome O Trust I-ORG Fellowship I-ORG in I-ORG Basic I-ORG Biomedical I-ORG Sciences[grant O number O 100246/Z/12/Z B-AWARD to O B.R O anEngineering O Physical I-ORG Sciences I-ORG Research I-ORG Councildoctoral O scholarship O to O S.D O EPSRC O ref O EP/G03706X/1 B-AWARD theCanadian O Institutes I-ORG of I-ORG Health I-ORG Research[MOP O 142424 I-AWARD to O T.A.Q O and O theNova O Scotia I-ORG Health I-ORG Research I-ORG Foundation[MED-EST-2014-9582 O to O T.A.Q O and O a O Marie O Skłodowska-Curie O Individual O Fellowship O from O the O H2020 O EU O Framework O Programme O for O Research O and O Innovation O Proposal O No: O 655020-DTI4micro-MSCA-IF-EF-ST O to O E.Z O This O research O was O funded O by O the O National B-ORG Science I-ORG Council I-ORG of O Taiwan O 103-2113-M-002-012 O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Taiwan I-ORG 105-2113-M-002-011 O and I-AWARD 106-2314-B-002-022-MY3 O and O National B-ORG Taiwan I-ORG University I-ORG Hospital I-ORG 107-003785 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 30470606 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Youth I-ORG Fund I-ORG Project I-ORG Grant O No. O 81403243 B-AWARD and O the B-ORG Chinese I-ORG Medicine I-ORG Science I-ORG and I-ORG Technology I-ORG project I-ORG of I-ORG Chongqing I-ORG Municipal I-ORG Health I-ORG Bureau I-ORG Grant I-ORG 2012-2-128 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31770322 O to O S.Y O the O Project O of O Sichuan B-ORG Province I-ORG Youth I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Team I-ORG 20CXTD0062 O to O S.Y O and O the O Applied B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG Sichuan I-ORG Province I-ORG 20YYJC4388 O to O Z.-W.Z O Research O was O supported O with O grants O from O the O German B-ORG Academic I-ORG Exchange I-ORG Agency I-ORG DAAD O A/96/05802 O A/03/22260 B-AWARD the O Secretary B-ORG Research I-ORG and I-ORG Technology I-ORG of I-ORG National I-ORG University I-ORG of I-ORG Río I-ORG Cuarto I-ORG SECyT-UNRC O PPI I-AWARD 18C/225 O National B-ORG Agency I-ORG of I-ORG Scientific I-ORG and I-ORG Technological I-ORG Promotion I-ORG ANPCyT O and O Fund B-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Research I-ORG FONCyT O Grant O PICT O 0932/2012 B-AWARD to O Adolfo O L. O Martino O Ulrich B-ORG Sinsch I-ORG was I-ORG funded I-ORG by I-ORG the I-ORG German I-ORG Academic I-ORG exchange I-ORG agency I-ORG DAAD O 961 I-AWARD 501 I-AWARD 027 I-AWARD 3; O 961 B-AWARD 501 I-AWARD 006 I-AWARD 5), O and O the O Volkswagenstiftung B-ORG #I/71 O 710 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O is O partially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 61672125 B-AWARD 61300086 I-AWARD 61432003 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG DUT15QY15 O the O Hong B-ORG Kong I-ORG Scholar I-ORG Program I-ORG No. O XJ2015008 B-AWARD and O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG Nos O 2013ZX04005-021 B-AWARD 2014ZX001011 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O is O supported O by O the O CHINA-CANADA B-ORG Joint I-ORG Initiative I-ORG on I-ORG Alzheimer’s I-ORG Disease I-ORG and I-ORG Related I-ORG Disorders I-ORG 81261120571 O Key B-ORG Medical I-ORG Professional I-ORG Development I-ORG Plan I-ORG of I-ORG Beijing I-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospitals I-ORG ZY201301 O China B-ORG National I-ORG Nature I-ORG Science I-ORG Foundation I-ORG 81530036 O Beijing O Scholars O Program O and O Beijing O Municipal O Science O O Technology O Commission O Z161100000216137 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31370245 O 31500454 O and O a O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG MOST I-ORG Grant I-ORG 2011FY120200-4 O 2012FY110400 O as O well O as O Southeast B-ORG Asia I-ORG Biodiversity I-ORG Research I-ORG Institute I-ORG Chinese I-ORG Academy I-ORG of I-ORG Science I-ORG Y4ZK111B01 O This O research O was O funded O by O the B-ORG National I-ORG Program I-ORG of I-ORG Key I-ORG Basic I-ORG Research I-ORG Project I-ORG 2014CB138703-2 O the B-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG ASTIP-IAS14 O and O the B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2017YFE0111000 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31501795 O 31501610 B-AWARD the B-ORG fundamental I-ORG research I-ORG funds I-ORG for I-ORG the I-ORG central I-ORG universities I-ORG KJQN201659 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG funded I-ORG project I-ORG 2014M560432 O 2015T80563 O and O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG in I-ORG China I-ORG BK20140695 O The O funding O bodies O had O no O role O in O study O design O data O collection O and O analysis O and O in O writing O the O manuscript O This O study O was O supported O by O the B-ORG Program I-ORG for I-ORG Innovative I-ORG Research I-ORG Team I-ORG 2011-CXTD-09 O of O Beijing O University O of O Chinese O Medicine O the B-ORG grant I-ORG of I-ORG Research I-ORG Capacity I-ORG Building I-ORG No. O 201207007 O from O the O State O Administration O of O Traditional O Chinese O Medicine O of O China O GY O Yang O and O JP O Liu O was O were O partially O funded O by O grant O number O R24 B-AWARD AT001293 I-AWARD from O the B-ORG National I-ORG Center I-ORG for I-ORG Complementary I-ORG and I-ORG Alternative I-ORG Medicine I-ORG NCCAM O of O the O US O National O Institutes O of O Health O www.nccam.nih.gov O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51904083 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guizhou I-ORG Province I-ORG Qian O Ke I-AWARD He I-AWARD Ji I-AWARD Chu I-AWARD 2020]1Y221 O Growth B-ORG Project I-ORG of I-ORG Young I-ORG Scientific I-ORG and I-ORG Technological I-ORG Talents I-ORG in I-ORG Universities I-ORG of I-ORG Guizhou I-ORG Province I-ORG Qian B-AWARD Jiao I-AWARD He I-AWARD KY I-AWARD Zi I-AWARD 2021)262 O and O Guizhou B-ORG Institute I-ORG of I-ORG Technology I-ORG high-level I-ORG talent I-ORG research I-ORG launch I-ORG project I-ORG XJGC20190963 O The O study O was O supported O by O the O Fund O of O Guangxi B-ORG Provincial I-ORG Health I-ORG Bureau I-ORG Scientific I-ORG Research I-ORG Project I-ORG Z2013201 O Z2014055 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangxi I-ORG China I-ORG 2015GXNSFCA139009 O and O the B-ORG Fund I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 81360327 I-AWARD NSFC I-AWARD 81560469 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Experiments O equipments O and O animal O housing O was O supported O by O grants O to O MCM O from O the O University O of O Geneva O Switzerland O the O Swiss B-ORG National I-ORG Science I-ORG Foundation I-ORG FNSNF O grants O CR32I3_162743 B-AWARD and O 31003A_179431 B-AWARD the O SystemsX.ch B-ORG initiative O project O EpiPhysX B-AWARD and O the O International B-ORG Human I-ORG Frontier I-ORG Science I-ORG Program I-ORG Organisation I-ORG HFSP O RGP0019/2017 B-AWARD The O funding O bodies O played O no O role O in O the O design O of O the O study O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O funded O by O the O Department B-ORG of I-ORG Scientific I-ORG Research I-ORG Project I-ORG in I-ORG Heilongjiang I-ORG Province O grant O number O LH2022B022 O and O the O APC O was O funded O by O Tianze O Liu O Jiamusi O University I-ORG Horizontal I-ORG Research I-ORG Project O grant O number O 210428001 O 021040301 B-AWARD and O the O APC O was O funded O by O Shuang O Liu O the O Innovation B-ORG and I-ORG Entrepreneurship I-ORG Project I-ORG for I-ORG College I-ORG Students I-ORG in I-ORG Heilongjiang I-ORG Province O grant O number O S202210222018 O and O the O APC O was O funded O by O Tianze O Liu O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 62105056 B-AWARD the O Special B-ORG Projects I-ORG in I-ORG Key I-ORG Fields I-ORG of I-ORG Regular I-ORG Colleges I-ORG and I-ORG Universities I-ORG in I-ORG Guang-dong I-ORG Province I-ORG no. O 2022ZDZX1046 B-AWARD the O Engineering B-ORG Technology I-ORG Research I-ORG Center I-ORG of I-ORG Colleges I-ORG and I-ORG Universities I-ORG in I-ORG Guang-dong I-ORG Province I-ORG no. O 2021GCZX005 B-AWARD and O the O Innovation B-ORG Team I-ORG of I-ORG Colleges I-ORG and I-ORG Universities I-ORG in I-ORG Guang-dong I-ORG Province I-ORG no. O 2021KCXTD040 B-AWARD This O work O was O supported O by O Japan B-ORG Agency I-ORG for I-ORG Medical I-ORG Research I-ORG and I-ORG Development I-ORG AMED O grant O number O of O 16ck0106133h0103 B-AWARD and O 16ck0106136h0103 B-AWARD to O TW O Ministry B-ORG of I-ORG Education I-ORG Culture I-ORG Sports I-ORG Science I-ORG and I-ORG Technology I-ORG grant O number O of O 221S0001 B-AWARD and O 26293226 B-AWARD to O TW O the B-ORG Japanese I-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science O DC1 O grant O number O of O 24.6916 B-AWARD to O SF O This O work O is O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Project O Number O 81101671 B-AWARD and O 81301904 B-AWARD for O the O design O of O the O study O and O collection O and O the O funder O is O the O last O corresponding O author O and O the O first O author O respectively O Medical B-ORG Scientific I-ORG Technology I-ORG and I-ORG Research I-ORG Fund I-ORG of I-ORG Guangdong I-ORG Project O Number O A2016023 B-AWARD for O the O animal O experiment O and O data O analysis O Special B-ORG Project I-ORG by I-ORG Guangdong I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG 2018YJ021 O for O the O interpretation O of O data O The O funder O of O the O last O two O funds O is O the O last O corresponding O author O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81771250 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province O China O 2020J011059 O 2020R1011004 B-AWARD 2021J01374 B-AWARD High-level B-ORG hospital I-ORG foster I-ORG grants I-ORG from I-ORG Fujian I-ORG Provincial I-ORG Hospital I-ORG Fujian I-ORG province O China O 2020HSJJ07 O Medical B-ORG innovation I-ORG project I-ORG of I-ORG Fujian I-ORG Province I-ORG 2021CXB002 O Fujian B-ORG Research I-ORG and I-ORG Training I-ORG Grants I-ORG for I-ORG Young I-ORG and I-ORG Middle-aged I-ORG Leaders I-ORG in I-ORG Healthcare I-ORG 2022 O This O research O was O financially O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O U1505243 B-AWARD 51805460 B-AWARD the O Science O and O Technology O Planning O Project O of O Fujian O Province O No. O 2018J01529 O 2018J01082 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 20720180067 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2018A030313522 B-AWARD and O the O Science O and O Technology O Planning O Project O of O Shenzhen O Municipality O in O China O No. O JCYJ20180306173000073 O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81870105 B-AWARD 81770107 B-AWARD and O 81920108004 O Key B-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Hunan I-ORG Provincial I-ORG Health I-ORG Commission I-ORG No.20201921 O and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFA0107800 O This O research O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31870081 O the O Special B-ORG Program I-ORG of I-ORG Talents I-ORG Development I-ORG for I-ORG Excellent I-ORG Youth I-ORG Scholars I-ORG in I-ORG Tianjin I-ORG TJTZJH-QNBJRC-2-10 O the O Youth B-ORG Innovation I-ORG Promotion I-ORG Association I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG 2016164 O and O the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Tianjin I-ORG 15PTCYSY00020 O and O 14ZCZDSY00157 B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81901071 O and O 81970993 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG 2019J01297 O and O 2019J05072 B-AWARD the O Medical O Innovation O Grant O of O Fujian O Province O 2019-CX-36 O and O Fujian B-ORG Medical I-ORG University I-ORG XRCZX2017007 O and O XRCZX2017019 B-AWARD The O funders O had O no O role O in O the O design O of O the O study O in O the O collection O analyses O or O interpretation O of O data O in O the O writing O of O the O manuscript O or O in O the O decision O to O publish O the O results O This O work O was O partly O supported O by O the O Earmarked B-ORG Fund I-ORG for I-ORG Hebei I-ORG Lays I-ORG Innovation I-ORG Team I-ORG of I-ORG Modern I-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG HBCT2018150210 O Science B-ORG and I-ORG Technology I-ORG Project I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG 18227517D O and O by O grants O for O one-hundred B-ORG outstanding I-ORG innovative I-ORG talents I-ORG from I-ORG Hebei I-ORG institution I-ORG of I-ORG higher I-ORG learning I-ORG SLRC2017039 O This O research O was O supported O by O a O grant O 2013ZX10002002-003-002 O from O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Projects O a O grant O 81301395 O from O the O Chinese B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG and O a O grant O cstc2015jcyjA10003 O from O the O Chongqing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG This O study O was O funded O by O Zhejiang B-ORG Province I-ORG Natural I-ORG Science I-ORG Foundation I-ORG NO. O LQ18H060001 B-AWARD Zhejiang B-ORG Province I-ORG Medical I-ORG and I-ORG Health I-ORG project I-ORG NO. O 2018269731 B-AWARD Zhejiang B-ORG Province I-ORG Chinese I-ORG Medicine I-ORG Project I-ORG NO. O 2015ZB028 B-AWARD and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China(NO O 81602312 B-AWARD The O funding O played O role O in O collecting O the O case O buying O the O literatures O of O nodular O fasciitis O and O analyzing O the O features O of O nodular O fasciitis O This O research O was O funded O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China O grant O number O 2017YFC0803901 B-AWARD Heilongjiang O highway O survey O and O design O institute O project O grant O number O 2018006 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 51108136 B-AWARD and O China B-ORG Scholarship I-ORG Council I-ORG Scholarship O grant O number O 201806120277 B-AWARD This O research O was O funded O by O grants O from O the O N.L B-ORG Tartar I-ORG foundation I-ORG FS009N-AMMS O and O the O Agricultural B-ORG Research I-ORG Foundation I-ORG VMD512-ALX9 O of O Oregon O State O University O to O M.R.S O and O by O grants O IFP-2020-122 O from O Ministry B-ORG of I-ORG Education I-ORG Saudi I-ORG Arabia I-ORG to O S.B O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81770458 B-AWARD 81500389 B-AWARD Key B-ORG Project I-ORG of I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 2017ZDCXL-SF-02-04-01 O and O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC1311505 O Dr. O Rasooly’s O effort O was O supported O by O the O Pediatric O Hospital O Epidemiology O and O Outcomes O Training O PHEOT O Program O at O The O Children’s O Hospital O of O Philadelphia O funded O by O Institutional O Research O Training O Grant O 5T32HD060550-09 B-AWARD from O the O Eunice B-ORG Kennedy I-ORG Shriver I-ORG National I-ORG Institute I-ORG of I-ORG Child I-ORG Health I-ORG and I-ORG Human I-ORG Development I-ORG of O the O National O Institutes O of O Health O This O study O is O supported O by O Cooperative O Agreement O 1U01HL143475-01 B-AWARD from O the O National B-ORG Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute I-ORG of O the O National O Institutes O of O Health O Bonafide O PI O Dr. O Bonafide’s O effort O developing O this O protocol O was O supported O by O Career O Development O Award O 5K23HL116427-04 B-AWARD from O the O National O Heart O Lung O and O Blood O Institute O of O the O National O Institutes O of O Health O Bonafide O PI O Dr. O Wolk O is O an O investigator O with O the O Implementation O Research O Institute O IRI O at O the O George O Warren O Brown O School O of O Social O Work O Washington O University O in O St. O Louis O through O an O award O from O the O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health I-ORG 5R25MH08091607 O and O the O Department O of O Veterans O Affairs O Health O Services O Research O O Development O Service O Quality O Enhancement O Research O Initiative O QUERI O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81771936 I-AWARD to O JSL O No. B-AWARD 81801796 I-AWARD to O YT) O and O Major B-ORG Scientific I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Lab I-ORG 2018DG0ZX01 O to O JSL O which O provide O financial O support O in O the O design O of O study O analysis O of O data O and O writing O the O manuscript O the O National O Natural O Science O Foundation O of O China O No. O 81672916 I-AWARD to O JL) O and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFC0908200 I-AWARD to O KD O which O provide O financial O support O in O analysis O and O interpretation O of O data O This O research O was O supported O by O the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0505903 O FLL O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2015ZCQ-BH-01 O FHY O and O the B-ORG National I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31670428 O FLL O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O C.-S.C O is O supported O by O NSF B-ORG DMS B-AWARD 1813071 I-AWARD and O DMS B-AWARD 1253481 O W.-C.L O is O supported O by O the O General B-ORG Research I-ORG Fund I-ORG of I-ORG the I-ORG Research I-ORG Grants I-ORG Council I-ORG of I-ORG the I-ORG Hong I-ORG Kong I-ORG Special I-ORG Administrative I-ORG Region I-ORG project O no. O CityU B-AWARD 11303117 O and O CityU B-ORG Strategic I-ORG Research I-ORG Grant I-ORG project O no. O CityU B-AWARD 11300518 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 31871571 B-AWARD the O Shanxi B-ORG Modern I-ORG Agricultural I-ORG Industry I-ORG Technology I-ORG System I-ORG coarse O cereals O grant O number O 2022-03 B-AWARD and O the O Scientific B-ORG and I-ORG Technological I-ORG Innovation I-ORG Fund I-ORG of I-ORG Shanxi I-ORG Agricultural I-ORG University O grant O numbers O 2018YJ17 B-AWARD and O 2020BQ32 B-AWARD This O research O was O funded O by O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Taiwan O grants O number O MOST B-AWARD 108-2811-B-006-501 O MOST B-AWARD 108-2811-B-006-525 O MOST B-AWARD 106-2314-B-006-074-MY3 O MOST B-AWARD 109-2314-B-006-078 O and O MOST B-AWARD 109-2314-B-006-084-MY3 O National B-ORG Cheng I-ORG Kung I-ORG University O the O grant O number O HUA B-AWARD 109-3-7-156 O National O Cheng O Kung O University O Hospital O grant O number O NCKUH-10902034 B-AWARD and O Chi B-ORG Mei I-ORG Medical I-ORG Center I-ORG for O financial O support O the O grants O number O CMNCKU10505 B-AWARD CMNCKU10609 B-AWARD and O CMNCKU10715 B-AWARD This O work O is O funded O by O the O Special B-ORG Scientific I-ORG Research I-ORG Fund I-ORG of I-ORG Public I-ORG Welfare I-ORG Profession I-ORG of I-ORG Ministry I-ORG of I-ORG Water I-ORG Resources I-ORG of I-ORG China I-ORG no. O 200701022 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG nos O 61427802 B-AWARD 41330634 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG China I-ORG nos O 2-9-2015-071 B-AWARD 2-9-2017-089 B-AWARD This O research O is O supported O by O National B-ORG Social I-ORG Science I-ORG Fund I-ORG Project I-ORG of I-ORG China I-ORG 15BGL041 O Social B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG 15YBA014 O and O Key B-ORG Project I-ORG of I-ORG Education I-ORG Office I-ORG of I-ORG Hunan I-ORG Province(17A014 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Conicyt-PIA B-ORG Concurso I-ORG AFB I-ORG 170001 B-AWARD Fondap B-ORG 150900007 B-AWARD MAIA O STIC-AmSud O and O CONICYT B-ORG PFCHA/BECA I-ORG DOCTORADO I-ORG NACIONAL I-ORG 2014/FOLIO B-AWARD 21140124 I-AWARD granted O to O A.D.G O This O research O was O partially O supported O by O the O supercomputing O infrastructure O of O the O NLHPC O ECM-02 O and O ANR-16-CE23-0001 O ASTER O project O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81871709 B-AWARD the O National B-ORG Key I-ORG Programs I-ORG for I-ORG Infectious I-ORG Diseases I-ORG of I-ORG China I-ORG No. O 2017ZX10103008-005 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province O China O No. O LY16H200001 B-AWARD the O Scientific B-ORG Research I-ORG Projects I-ORG of I-ORG Education I-ORG of I-ORG Zhejiang I-ORG Province O China O No. O Y201534117 B-AWARD and O the O Scientific B-ORG Technology I-ORG Projects I-ORG of I-ORG Health I-ORG and I-ORG the I-ORG Family I-ORG Planning I-ORG Commission I-ORG of O Zhejiang O Province O No. O 2015KYB149 B-AWARD This O work O was O financially O supported O by O grants O from O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2018LC017 O the O National B-ORG Technical I-ORG System I-ORG of I-ORG Watermelon I-ORG and I-ORG Melon I-ORG Industry I-ORG CARS-25 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0100705 O Shandong B-ORG Provincial I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2019GNC106029 O and O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG Shandong I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG CXGC2018E08 O The O funding O bodies O played O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O The O study O received O the O following O grants O No.81400990 B-AWARD the O National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O No. B-AWARD 2014A030310197 I-AWARD the O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG of I-ORG China O No. B-AWARD 2016A020215113 I-AWARD the O Science I-ORG and I-ORG Technology I-ORG Plan I-ORG of I-ORG Guangdong I-ORG Province I-ORG of I-ORG China O No. B-AWARD 2016B017 I-AWARD the O President I-ORG Funding I-ORG of I-ORG Nanfang I-ORG Hospital I-ORG Southern I-ORG Medical I-ORG University O and O Ref B-AWARD No.17102915 I-AWARD Hong O Kong I-ORG RGC I-ORG GRF I-ORG Grant O This O work O was O funded O by O the O Czech B-ORG Academy I-ORG of I-ORG Sciences I-ORG RVO O 86652036 B-AWARD the O Czech B-ORG Science I-ORG Foundation I-ORG 21-31806 O 5R01CA249248-02 B-AWARD from O the O NIH B-ORG and O the O project O National B-ORG Institute I-ORG for I-ORG Cancer I-ORG Research I-ORG Programme O EXCELES O ID O Project O No. O LX22NPO5102 B-AWARD This O study O was O supported O by O the O Scientific B-ORG and I-ORG Technological I-ORG Support I-ORG Plan I-ORG Projects I-ORG of I-ORG China O No. B-AWARD 2007BAI05B05 O Medical B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Henan I-ORG Province O No. B-AWARD 201602012 O and O the O Youth B-ORG Fund I-ORG of I-ORG the I-ORG First I-ORG Affiliated I-ORG Hospital I-ORG of I-ORG Zhengzhou I-ORG University I-ORG [2012]233 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O under O Grants O 81402851 O 81573281 B-AWARD and O 81603529 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province O under O Grant O BK20140957 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities O under O Grant O 2015ZD009 B-AWARD and O Jiangsu B-ORG Qing I-ORG Lan I-ORG Project I-ORG Top-notch I-ORG Academic I-ORG Programs I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions O under O Grant O TAPP-PPZY2015A070 O Children’s O Hospital O Foundation O and O University O of O Queensland O Strategic O Funding O H2020 B-ORG European I-ORG Research I-ORG Council O Grant/Award O Number O 771057 B-AWARD H2020 B-ORG Marie I-ORG Skłodowska-Curie I-ORG Actions O Grant/Award O Number O 721567 B-AWARD Medical O Research O Council O Professorship O Award O Grant/Award O Number O G19/2 O MRC O Integrative O Epidemiology O Unit O University O of O Bristol O Grant/Award O Number O MC_UU_00011/7 O Sir O Henry O Wellcome O Postdoctoral O Fellowship O ZonMw B-ORG Grant/Award O Numbers O 531003014 B-AWARD 849200011 B-AWARD The O main O work O was O supported O from O the O Opening B-ORG Project I-ORG of I-ORG National I-ORG Engineering I-ORG Research I-ORG Center I-ORG for I-ORG Oil-tea I-ORG Camellia I-ORG 2014CY01 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21176106 O 21407046 B-AWARD Part O of O the O support O was O from O and O Fundamental O Research O Funds O for O the O Central O Universities O JUSRP51635B O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Pulp I-ORG and I-ORG Paper I-ORG Engineering I-ORG 201513 O and O Key O Laboratory O of O Advanced O Textile O Materials O and O Manufacturing O Technology O 2015002 O This O work O was O supported O by O the O Medical B-ORG Research I-ORG Council I-ORG MRC O grants O G0900278 B-AWARD and O U117532067 B-AWARD the O Wellcome B-ORG Trust I-ORG grant O 087792 B-AWARD and O the O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG David O Phillips O Research O Fellowship O to O E.W.T O grant O BB/D02014X/1 B-AWARD We O are O also O grateful O to O Imperial O College O for O an O Imperial O College O President O and O Rector's O award O and O the O Student O Opportunities O Fund O for O funding O We O are O grateful O to O Prof O Deborah O Smith O University O of O York O Dr O J. O Hutton O Imperial O College O and O colleagues O for O helpful O discussions O and O Diamond O Light O Source O Harwell O UK) O for O provision O of O excellent O synchrotron O radiation O facilities O This O work O was O supported O by O the O American B-ORG Foundation I-ORG of I-ORG Suicide I-ORG Prevention I-ORG grant O number O SRG-0-169-12 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangxi I-ORG Province I-ORG grant O number O 2014GXNSFBA118163 B-AWARD and O the O Innovation B-ORG Project I-ORG of I-ORG Guangxi I-ORG Graduate I-ORG Education I-ORG grant O number O YCSW2019100 B-AWARD and O JGY2019048 O and O was O carried O out O in O Hunan O Shandong O and O Guangxi O provinces O in O China O The O funding O sources O had O no O such O involvement O in O the O conduct O of O the O research O or O preparation O of O the O article O This O research O was O funded O by O research O grants O from O Spanish B-ORG Agencia I-ORG Estatal I-ORG de I-ORG Investigación I-ORG and I-ORG European I-ORG Fund I-ORG of I-ORG Regional I-ORG Development I-ORG PID2019-103969RB-C31/AEI/10.13039/501100011033 O and O Xunta B-ORG de I-ORG Galicia I-ORG Axudas O para O a O consolidación O e O estruturación O de O unidades O de O investigación O competitivas O e O outras O accións O de O fomento O nas O universidades O do O SUG O ED431B B-AWARD 2022/01 O to O J.L.S O J.C O and O S.C O were O recipients O of O a O predoctoral O fellowship O Program O FPU O from O Spanish B-ORG Ministerio I-ORG de I-ORG Educación O Cultura O y O Deporte O FPU19/00122 O and O FPU16/00045 B-AWARD respectively O A.M.B O was O recipient O of O a O postdoctoral O fellowship O Program O Juan O de O la O Cierva O Incorporación O from O Spanish B-ORG Ministerio I-ORG de I-ORG Ciencia I-ORG e I-ORG Innovación I-ORG IJC2019-039166-I O This O work O has O been O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61201153 O the B-ORG National I-ORG 973 I-ORG Program I-ORG of I-ORG China I-ORG under I-ORG Grant I-ORG 2012CB315805 O CCF B-ORG Venus I-ORG Research I-ORG Project I-ORG CCF-VenustechRP2016004 O Prospective B-ORG Research I-ORG Project I-ORG on I-ORG Future I-ORG Networks I-ORG in I-ORG Jiangsu I-ORG Future I-ORG Networks I-ORG Innovation I-ORG Institute I-ORG BY2013095-2-16 O This O paper O was O partly O supported O by O the O grants O from O the O Key B-ORG Project I-ORG from I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 50637020 O Tianjin B-ORG Municipal I-ORG Health I-ORG Burea I-ORG Fund I-ORG 2011KZ106 O Tianjin B-ORG Municipal I-ORG Education I-ORG Commission I-ORG Fund I-ORG 20120127 O and O Tianjin B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG Fund I-ORG 14JCYBJC28400 O This O research O was O funded O by O ANPCyT B-ORG grant O number O PICT B-AWARD 2014-1314 O CONICET B-ORG grant O number O 112-201101-00432 B-AWARD and O UNMdP B-ORG grant O number O 15/G527 B-AWARD This O work O was O supported O by O Shanghai B-ORG Shen I-ORG Kang I-ORG Hospital I-ORG Development I-ORG Center I-ORG Municipal I-ORG Hospital I-ORG New I-ORG Frontier I-ORG Technology I-ORG Joint I-ORG Project I-ORG SHDC12017105 O the O Key B-ORG project I-ORG of I-ORG Chongqing I-ORG Natural I-ORG Science I-ORG Foundation I-ORG cstc2020jcyj-zdxmX0011 O Chongqing O Natural O Science O Foundation O cstc2020jcyj-msxmX0012 O This O study O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG Program I-ORG 2021YFD1600200 O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG 25-LZIHPS-01 O the O National B-ORG Beef I-ORG Cattle I-ORG Industry I-ORG Technology I-ORG and I-ORG System I-ORG CARS-37 O the O Gansu B-ORG Basic I-ORG Research I-ORG Innovation I-ORG Group I-ORG Program I-ORG Research I-ORG on I-ORG Innovation I-ORG of I-ORG Yak I-ORG Molecular I-ORG Breeding I-ORG Technology I-ORG 20JR5RA580 O the O Science B-ORG and I-ORG Technology I-ORG Aid I-ORG Qinghai I-ORG Cooperation I-ORG Special I-ORG Project I-ORG 2020-QY-212 O and O the O Special B-ORG Fund I-ORG for I-ORG Basic I-ORG Research I-ORG Business I-ORG Expenses I-ORG of I-ORG the I-ORG Central-level I-ORG Public I-ORG Welfare I-ORG Research I-ORG Institutes I-ORG 1610322022008 O This O study O was O supported O by O the O financial O support O from O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M640837 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD1000601 O the O Guangdong B-ORG Natural I-ORG Science I-ORG Foundation I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholar I-ORG 2016A030306039 O and O the O Guangdong O Provincial O Special O Fund O For O Modern O Agriculture O Industry O Technology O Innovation O Teams O 2019LM1143 O This O paper O is O supported O by O Heilongjiang B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Project I-ORG Code O LH2019G012 B-AWARD PhD B-ORG Startup I-ORG Fund I-ORG Code O XDB201810 B-AWARD and O Research B-ORG and I-ORG Cultivation I-ORG Fund I-ORG Code O RRCPY201804 B-AWARD from O Heillongjiang O Bayi O Agriculture O University O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Fundación B-ORG Séneca I-ORG grant O number O 22080/JLI/22 B-AWARD and O by O the O Institute B-ORG of I-ORG Health I-ORG “Carlos I-ORG III” I-ORG ISCIII O co-funded O by O the O Fondo O Europeo O de O Desarrollo O Regional-FEDER O grant O number O PI20/00505 B-AWARD M.A.M-S O was O supported O by O PFIS O predoctoral O fellowship O from O the O ISCIII O F121/0003 O ISCIII O Spain O co-funded O by O the O Fondo O Europeo O de O Desarrollo O Regional O FEDER O B.R-M O was O supported O by O the O “Miguel B-ORG Servet I-ORG Type I-ORG I” I-ORG program I-ORG CP19/00098 O ISCIII O Spain O co-funded O by O the O Fondo O Europeo O de O Desarrollo O Regional-FEDER O The O funding O organizations O played O no O role O in O the O design O of O the O study O review O and O interpretation O of O the O data O or O final O approval O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Project O No. O 61505069 B-AWARD 61705087 I-AWARD 61675092 I-AWARD 61705089 I-AWARD 61775084 O National B-ORG Major I-ORG Project I-ORG of I-ORG China I-ORG Project O No. O J–GFZX0205010501.12 B-AWARD GFZX0205010501.24–J O Guangdong B-ORG Special I-ORG Support I-ORG Program I-ORG Project O No. O 2016TQ03X962 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG Project O No. O 2015A030306046 B-AWARD 2016A030310098 I-AWARD 2016A030311019 O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Guangzhou I-ORG Project O No. O 201605030002 B-AWARD 201607010134 I-AWARD 201704030105 O and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG (Project O No. O 21619409 B-AWARD 21619410 O The O study O was O supported O in O part O by O research O grants O from O the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No O 2017YFC1310100 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No O 81772448 B-AWARD 81501099 B-AWARD and O 81861138008 B-AWARD and O the B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG No O 2016ZDJS07A11 B-AWARD China O This O work O was O supported O by O an O Economic B-ORG Development I-ORG and I-ORG Innovation I-ORG Operative I-ORG Programme I-ORG Grant O GINOP B-AWARD 2.3.2-15-2016-00048 I-AWARD to O PH; O a O Human B-ORG Resources I-ORG Development I-ORG Operational I-ORG Programme I-ORG of I-ORG the I-ORG European I-ORG Union I-ORG and I-ORG the I-ORG Hungarian I-ORG Government I-ORG EFOP-3.6.2-16-2017-0006 B-AWARD and I-AWARD EFOP-3.6.3-VEKOP-16-2017-00009 I-AWARD to O PH; O and O by O New B-ORG National I-ORG Excellence I-ORG Program I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Human I-ORG Capacities O ÚNKP-17-3-II B-AWARD and I-AWARD ÚNKP-18-3-I I-AWARD to O ZS. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Research O reported O in O this O publication O was O supported O by O the O National B-ORG Cancer I-ORG Institute I-ORG R01CA197488 O BACH O National B-ORG Institute I-ORG of I-ORG Diabetes I-ORG and I-ORG Digestive I-ORG and I-ORG Kidney I-ORG Diseases I-ORG R01DK099528 O BACH O and O the O National B-ORG Institute I-ORG of I-ORG Biomedical I-ORG Imaging I-ORG and I-ORG Bioengineering I-ORG T32EB019944 O JEC O JL O The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O NIH O The O authors O are O also O grateful O for O additional O funding O provided O by O the O Department O of O Chemical O O Biomolecular O Engineering O BACH O and O the O Carl O R. O Woese O Institute O for O Genomic O Biology O BACH O at O the O University O of O Illinois O at O Urbana-Champaign O Development O and O maintenance O of O the O GBM O PDC O models O was O supported O by O Mayo O Clinic O the O Mayo O SPORE O in O Brain O Cancer O P50 O CA108961 O and O the O Mayo B-ORG Clinic I-ORG Brain I-ORG Tumor I-ORG Patient-Derived I-ORG Xenograft I-ORG National I-ORG Resource I-ORG R24 O NS092940 O This O study O was O supported O by O the O Basic O Science O Research O Program O from O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O funded O by O the O Ministry O of O Education O 2017R1D1A1B04033060 O by O the O Korea B-ORG Institute I-ORG of I-ORG Energy I-ORG Technology I-ORG Evaluation I-ORG and I-ORG Planning I-ORG KETEP O and O the O Ministry O of O Trade O Industry O O Energy O MOTIE O Nos O 20172510102150 B-AWARD and O 20172510102160 B-AWARD and O by O 2017 O Research O Grant O from O Kangwon B-ORG National I-ORG University O Korea O No. O 520170539 B-AWARD This O study O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 61602419 B-AWARD the O Chinese B-ORG medicine I-ORG research I-ORG foundation I-ORG project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG grant O number O 2018ZA037 B-AWARD of O China O Zhejiang B-ORG provincial I-ORG medicine I-ORG and I-ORG health I-ORG discipline I-ORG platform I-ORG project I-ORG grant O number O 2018RC058 B-AWARD Zhejiang B-ORG provincial I-ORG health I-ORG department I-ORG platform I-ORG backbone I-ORG project I-ORG grant O number O 2016147237 B-AWARD The O funders O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O funded O by O the O UC O Davis O School O of O Medicine O Dean’s O Fellowship O to O A.W O awards O National B-ORG Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute I-ORG of O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH O under O Award O Number O U54HL119893 B-AWARD and O by O the O National B-ORG Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences I-ORG through O grant O number O UL1 B-AWARD TR001860 O NIH O grants O 5R01NS100761-02 B-AWARD and O R03HD091601-01 B-AWARD Shriners B-ORG Hospitals I-ORG for I-ORG Children I-ORG research O grants O 85119-NCA-18 O 87200-NCA-19 B-AWARD 85108-NCA-19 B-AWARD and O the O March B-ORG of I-ORG Dimes I-ORG Foundation I-ORG Basil O O’Connor O Starter O Scholar O Research O Award O 5FY1682 O This O study O was O supported O by O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG No. O 2012B031800176 B-AWARD Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangzhou I-ORG City I-ORG China I-ORG No. O 201300000140 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81573638 O Science B-ORG Program I-ORG for I-ORG Overseas I-ORG Scholar I-ORG of I-ORG Guangzhou I-ORG University I-ORG of I-ORG Chinese I-ORG Medicine I-ORG Torch I-ORG Program I-ORG No. O XH20150107 B-AWARD and O The B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2016A030313859 B-AWARD This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0201104 O 2018YFD0300900 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31872017 O 31571971 I-AWARD 31371904 I-AWARD 31801787 I-AWARD 31901925 O Zhejiang O Provincial O Natural O Science O Foundation O of O China O LZ19C140002 O Zhejiang B-ORG Provincial I-ORG Project I-ORG 2017C02002 O 2019C02006 B-AWARD 2020C02006 O Shanghai O Agriculture O Applied O Technology O Development O Program O 2019-02-08-00-08-F01150 O the O Fundamental O Research O Funds O for O the O Central O Universities O Dabeinong O Funds O for O Discipline O Development O and O Talent O Training O in O Zhejiang O University O and O Key O Subject O Construction O Program O of O Zhejiang O for O Modern O Agricultural O Biotechnology O and O Crop O Disease O Control O This O study O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 41571048 B-AWARD the B-ORG Key I-ORG National I-ORG R I-ORG I-ORG D I-ORG program I-ORG of I-ORG China I-ORG Grant O No. O 2016YFC0500502 B-AWARD and O the B-ORG State I-ORG Key I-ORG Basic I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG of I-ORG China I-ORG Grant O No. O 2014CB138803 B-AWARD This O study O is O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG No. O C2018201139 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 31872274 B-AWARD 31702043 I-AWARD and I-AWARD 32070473 O and O the O Post-graduate’s B-ORG Innovation I-ORG Fund I-ORG Project I-ORG of I-ORG Hebei I-ORG University I-ORG No. O hbu2019ss022 B-AWARD There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O study O was O supported O by O the O Science B-ORG and I-ORG Technology I-ORG Development I-ORG Plan I-ORG of I-ORG Jilin I-ORG Province I-ORG No: O 20160520148JH B-AWARD the B-ORG Training I-ORG Program I-ORG for I-ORG Youth I-ORG in I-ORG the I-ORG Health I-ORG and I-ORG Family I-ORG Plan I-ORG ning I-ORG Commission I-ORG of I-ORG Jilin I-ORG Province I-ORG No: O 2017Q018 B-AWARD the B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG in I-ORG Chinese I-ORG Medicine I-ORG of I-ORG Jilin I-ORG Province I-ORG No: O 2017244 B-AWARD the B-ORG scientific I-ORG and I-ORG technological I-ORG research I-ORG project I-ORG of I-ORG the I-ORG education I-ORG department I-ORG of I-ORG Jilin I-ORG Rrovince I-ORG N0: O JJKH20180199KJ B-AWARD This O work O was O supported O by O the O Dup15q B-ORG Alliance I-ORG 20182241 O Saravanapandian O the O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health I-ORG of O the O National O Institute O of O Health O T32MH073526 B-AWARD Saravanapandian O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG R01 O GM111378-01A1 I-AWARD Senturk O and O the O UCLA O Intellectual B-ORG and I-ORG Developmental I-ORG Disabilities I-ORG Research I-ORG Center I-ORG U54HD087101-04 B-AWARD Jeste O The O work O was O supported O by O the O Chinese B-ORG National I-ORG Science I-ORG Foundation I-ORG 31070972 O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG 16ZR1418300 O the O Program O for O Innovative O Research O Team O of O Shanghai O Municipal O Education O Commission O the O Shanghai B-ORG Eastern I-ORG Scholar I-ORG Program I-ORG J50201 O and O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2012CB910401 O All O of O the O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O in O part O by O Shanghai B-ORG Science I-ORG I-ORG Technology I-ORG Support I-ORG Program I-ORG 13431900401 O Shanghai B-ORG Science I-ORG I-ORG Technology I-ORG Innovation I-ORG Action I-ORG Program I-ORG 15140904800 O the B-ORG National I-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81373964 O and O the B-ORG National I-ORG Science I-ORG I-ORG technology I-ORG Major I-ORG Project I-ORG of I-ORG China I-ORG 2014ZX09301-306-03 O through O grants O to O Dr. O Xuan O Liu O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O is O supported O by O Hainan B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 2019RC018 B-AWARD and O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hainan[617048 O 2018CXTD333 O and O by O the O Science B-ORG and I-ORG Technology I-ORG Research I-ORG Project I-ORG of I-ORG Chongqing I-ORG Education I-ORG Commission I-ORG KJQN201800442 O and O by O the O Special B-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG Philosophy I-ORG and I-ORG Social I-ORG Sciences I-ORG of I-ORG Chongqing I-ORG Medical I-ORG University I-ORG 201703 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.31572612 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG No. O 2015A030313150 O Special B-ORG Fund I-ORG for I-ORG Marine I-ORG Fisheries-Scientific I-ORG Research I-ORG of I-ORG Guangdong I-ORG Province I-ORG A201501A04 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O NSFC B-ORG 81670154/H0812,81470355/H1616 O and I-AWARD 81100378/H0812 O Projects O 201707010352 O 1201410214 I-AWARD 2014A030313492 I-AWARD 201528042 O from O the O Foundation B-ORG of I-ORG Guangzhou I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Committee I-ORG Bureau I-ORG of I-ORG Education I-ORG of I-ORG Guangzhou I-ORG Municipality I-ORG GD-NSF I-ORG and I-ORG Guangdong I-ORG special I-ORG support I-ORG scheme I-ORG to O XS O The O National B-ORG Funds I-ORG for I-ORG developing I-ORG local I-ORG colleges I-ORG and I-ORG universities I-ORG B16056001 O GD-NSF B-ORG for I-ORG research I-ORG team I-ORG 2018B030312001 O NSFC O 81272451/H1609 O 81472762/H1609 O and O MOE B-ORG 20134423110002 O to O JL O This O work O is O supported O by: O 1) O the O Project B-ORG of I-ORG Guangdong I-ORG Education I-ORG Bureau I-ORG which O involves O the O graduate O training O of O government O university O and O enterprise O by O the O Southern O University O of O Science O and O Technology—Leju O Shenzhen O Robotic O Corporation O NO. O Y01331833 B-AWARD 2) O the O public B-ORG welfare I-ORG technology I-ORG research I-ORG project I-ORG of I-ORG Zhejiang I-ORG Provinces I-ORG Science I-ORG Foundation I-ORG in I-ORG China I-ORG The O effect O model O construction O and O 3D O visualization O of O auricular O point O pivot O regulation O of O brain O neural O NO. O LGF20F020009 B-AWARD and O 3) O the O key B-ORG R&D I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Province I-ORG focusing I-ORG on I-ORG the I-ORG research I-ORG and I-ORG application I-ORG development I-ORG of I-ORG medical I-ORG nursing I-ORG care I-ORG robot I-ORG and I-ORG elderly I-ORG care I-ORG service I-ORG system I-ORG of I-ORG internet I-ORG hospitals O Research O on O intelligent O service O technology O and O equipment O of O health O and O elderly O care-support O the O research O and O application O development O of O medical O nursing O care O robot O and O elderly O care O service O system O of O internet O hospitals O NO. O 2020C03107 B-AWARD This O work O is O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 31970463 B-AWARD Laboratory B-ORG of I-ORG Lingnan I-ORG Modern I-ORG Agriculture I-ORG Project I-ORG NZ2021021 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2022A1515010498 O This O work O was O financially O supported O by O National O Science O and O Technology O Major O Projects O for O “Major O New I-ORG Drugs I-ORG Innovation I-ORG and I-ORG Development” O 2018ZX09711003-008-002 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG 18RZ1419700 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81973487 O 81573617 B-AWARD Funding O was O provided O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos.31572306 O 31272343 O the O Chinese B-ORG Universities I-ORG Scientific I-ORG Fund I-ORG YQ2013010 O and O the O West B-ORG Light I-ORG Foundation I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG 2012DF06 O to O Wu O Dai O This O work O was O supported O by O the O Basic O Research O Program O NRF-2017R1C1B2010278 O the O Nano⋅Material O Technology O Development O Program O NRF-2016M3A7B4900121 O and O the O Convergence O Technology O Development O Program O for O Bionic O Arm O NRF-2014M3C1B2048175 O through O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O grant O funded O by O the O Ministry O of O Science O and O ICT O Also O this O research O has O been O conducted O with O the O support O of O the O Korea B-ORG Institute I-ORG of I-ORG Industrial I-ORG Technology I-ORG kitech O JA-19-0001 O and O the O Gyeonggi-Do B-ORG Technology I-ORG Development I-ORG Program I-ORG kitech O IZ-19-0003 O as O “development O of O smart O textronic O products O based O on O electronic O fibers O and O textiles” O This O work O was O supported O by O the O National B-ORG Institute I-ORG of I-ORG Dental I-ORG and I-ORG Craniofacial I-ORG Research I-ORG NIDCR O U01 O DE025188 O the O National B-ORG Institute I-ORG of I-ORG Biomedical I-ORG Imaging I-ORG and I-ORG Bioengineering I-ORG R01 O EB020527 O and O the O National B-ORG Cancer I-ORG Institute I-ORG U01 O CA217851 O all O of O the O NIH O The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O NIH O The O funders O did O not O play O a O role O in O the O design O and O execution O of O this O study O The O studies O on O BLV O were O supported O by O Grants-in-Aid O for O Scientific O Research O A O 08021470 O A O 16H02590 O B O 10004294 O and O C O 25450405 O from O the O Japan B-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG JSPS O by O a O grant O from O Integration B-ORG Research I-ORG for I-ORG Agriculture I-ORG and I-ORG Interdisciplinary I-ORG Fields I-ORG in I-ORG Japan I-ORG 14538311 O and O by O a O grant O from O the O Project B-ORG of I-ORG the I-ORG NARO I-ORG Bio-oriented I-ORG Technology I-ORG Research I-ORG Advancement I-ORG Institution I-ORG the O special O scheme O project O on O regional O developing O strategy O Grant O No. O 16817983 B-AWARD This O work O was O supported O by O grants O of O National B-ORG Key I-ORG R&D I-ORG Projects I-ORG No. O 2017YFD0501104 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31672590 B-AWARD and O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG No. O 201803020005 B-AWARD This O work O was O supported O by O Ministry B-ORG of I-ORG Education I-ORG Culture I-ORG Sports I-ORG Science I-ORG and I-ORG Technology I-ORG 25293104 O 26640114 I-AWARD 15H02657 I-AWARD 16H05191 I-AWARD and I-AWARD 211S0002 O to O Yoshio O Yamaoka O National B-ORG Institutes I-ORG of I-ORG Health I-ORG DK62813 O to O Yoshio O Yamaoka O and O Ministry B-ORG of I-ORG Research I-ORG Technology I-ORG and I-ORG Higher I-ORG Education I-ORG of I-ORG Indonesia I-ORG for I-ORG World I-ORG Class I-ORG Professor I-ORG Program I-ORG no. O 105/D2.3/KP/2017 O to O Muhammad O Miftahussurur O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the B-ORG National I-ORG Social I-ORG Science I-ORG Foundation I-ORG project O 15CGL046 I-AWARD and O 16CGL046 B-AWARD the B-ORG Youth I-ORG Foundation I-ORG of I-ORG Humanities I-ORG and I-ORG Social I-ORG Sciences I-ORG by I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG the I-ORG People’s I-ORG Republic I-ORG of I-ORG China I-ORG project O 15YJCZH118 B-AWARD the B-ORG Scientific I-ORG Research I-ORG Projects I-ORG by I-ORG the I-ORG State I-ORG Ethnic I-ORG Affairs I-ORG Commission I-ORG projects O MSQ16002 O and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG projects O CSY16018 I-AWARD and O 2018QN050 B-AWARD This O study O was O funded O by O grants O of O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81660584 B-AWARD the B-ORG programs I-ORG for I-ORG New I-ORG Century I-ORG Excellent I-ORG Talents I-ORG in I-ORG University I-ORG NCET-13-0760 O Young B-ORG Talents’ I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG Hainan I-ORG Association I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG No. O 201509 B-AWARD Key B-ORG Research I-ORG Program I-ORG of I-ORG Hainan I-ORG Province I-ORG ZDYF2017099 O and O Key B-ORG lab I-ORG of I-ORG tropical I-ORG pharmaceutical I-ORG herb I-ORG chemistry I-ORG of I-ORG Hainan I-ORG province I-ORG Open I-ORG Fund I-ORG in I-ORG Hainan I-ORG Normal I-ORG University I-ORG No. O 201602 B-AWARD are O gratefully O acknowledged O JX O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Shenzhen B-ORG Natural I-ORG Science I-ORG Fund I-ORG the O Stable O Support O Plan O Program O 20220810124046002 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Council I-ORG of I-ORG Shenzhen I-ORG Nos O JCYJ20200109114237902 B-AWARD KQTD20170810105439418 B-AWARD and O the O joint O funding O program O of O Guang B-ORG Dong I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG and O Hongkong O Innovation O and O Technology O No. O 2021A0505110015 B-AWARD This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31602186 O Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG China I-ORG ZR2014CZ004 O ZR2014CQ051 B-AWARD and O University B-ORG Independent I-ORG Innovation I-ORG Project I-ORG of I-ORG Jinan I-ORG China I-ORG 200906020 O This O study O was O supported O by O the O Key B-ORG Project I-ORG of I-ORG Nanjing I-ORG Command I-ORG 14ZX25 O Key B-ORG Medicine I-ORG Project I-ORG of I-ORG PLA I-ORG CNJ15J004 O Cooperate B-ORG Project I-ORG of I-ORG Fujian I-ORG Province I-ORG 2015I0013 O and O Key O Project O of O Nanjing O Command O 15DX024 O This O work O was O supported O by O Laboratory B-ORG of I-ORG Lingnan I-ORG Modern I-ORG Agriculture I-ORG Project I-ORG NZ2021009 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2021A1515012479 O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD1000404 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31672188 O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG 2021A1515111227 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31601377 O the O “Young B-ORG Talents” I-ORG Project I-ORG of I-ORG Northeast I-ORG Agricultural I-ORG University I-ORG 17QC02 O and O the O Heilongjiang B-ORG Provincial I-ORG government I-ORG Postdoctoral I-ORG Foundation I-ORG of I-ORG China I-ORG LBH-Z16188 O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81771589 B-AWARD the B-ORG Program I-ORG of I-ORG Tianjin I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG grant O number O 18ZXDBSY00170 B-AWARD and O the B-ORG Key I-ORG Project I-ORG of I-ORG Tianjin I-ORG Health I-ORG Care I-ORG Professionals I-ORG grant O number O 16KG166 B-AWARD The O fund O body O was O not O involved O in O the O project O design O data O collection O analysis O etc O This O study O was O supported O in O part O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81772257 O Youth B-ORG cultivation I-ORG program I-ORG of I-ORG Southern I-ORG Medical I-ORG University I-ORG PY2018N076 O and O Medical B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG A2019557 O Funded O by O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31460595 O Major B-ORG Projects I-ORG of I-ORG Jiangxi I-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG 2015ACF60019 O Jiangxi B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Landing I-ORG Project I-ORG KJLD14102 O and O Science B-ORG Technology I-ORG Program I-ORG of I-ORG Jiangxi I-ORG Education I-ORG Department I-ORG GJJ14781 O This O work O was O supported O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.U1605213 O and O 31872564 B-AWARD Earmarked B-ORG Fund I-ORG for I-ORG Modern I-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG No. O CARS-49 O Key B-ORG S I-ORG I-ORG T I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG No. O 2016GGH4513 O and O Xiamen B-ORG Southern I-ORG Oceanographic I-ORG Center I-ORG No. O 18GZY012HJ02 O This O work O was O co-funded O by O the B-ORG National I-ORG Science I-ORG Foundation I-ORG of I-ORG China(No.8133016,81630038,81771634 O the O Major I-ORG State I-ORG Basic I-ORG Research I-ORG Development I-ORG Program(2017YFA0104200 O Grants B-ORG from I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG of I-ORG Sichuan I-ORG Province(2014SZ0149,2016TD0002 O and O the O Grant I-ORG of I-ORG clinical I-ORG discipline I-ORG program(neonatology)from I-ORG Ministry I-ORG of I-ORG Health I-ORG of I-ORG China(1311200003303 O The O funder O had O no O role O in O the O study O design O data O collection O data O analysis O and O interpretation O preparation O of O the O manuscript O or O decision O to O publish O This O work O was O supported O by O the O Russian B-ORG Science I-ORG Foundation I-ORG project O nos O 17-75-20205 B-AWARD K.S.A O for O the O LС-MS/MS O analysis O and O 14-50-00131 B-AWARD G.P.A O for O the O in O vitro O experiments O the O Russian B-ORG Foundation I-ORG for I-ORG Basic I-ORG Research I-ORG projects O nos O 18-34-00622 B-AWARD K.S.A O 16-04-01414 B-AWARD V.O.S O 17-00-00172 B-AWARD M.A.L O 16-04-01209 B-AWARD M.S.P O and O 17-29-06056 B-AWARD M.S.P O the O Scholarship B-ORG of I-ORG the I-ORG President I-ORG of I-ORG the I-ORG Russian I-ORG Federation I-ORG SP-4811.2018.4 B-AWARD V.O.S O the O Grant B-ORG of I-ORG the I-ORG President I-ORG of I-ORG the I-ORG Russian I-ORG Federation I-ORG МК-6894.2018.4 B-AWARD G.P.A O the O Program B-ORG of I-ORG the I-ORG Presidium I-ORG of I-ORG the I-ORG Russian I-ORG Academy I-ORG of I-ORG Sciences I-ORG “Molecular I-ORG and I-ORG Cellular I-ORG Biology” I-ORG project O no. B-AWARD 0101-2015-0027 I-AWARD M.S.P O This O study O was O funded O by O National B-ORG Youth I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81403045 O Guangxi B-ORG Youth I-ORG Science I-ORG Foundation I-ORG 2014GXNSFBA118204 O and O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG China I-ORG 2012ZX09304006 O This O research O was O funded O by O Universiti B-ORG Kebangsaan I-ORG Malaysiagrant I-ORG GGPM-2021-059 O the O Ministry B-ORG of I-ORG Higher I-ORG Education I-ORG grant O FRGS/1/2021/TK0/UKM/02/27 O and O Dana B-ORG Pecutan I-ORG Universiti I-ORG Kebangsaan I-ORG Malaysia I-ORG PP-SELFUEL-2023 O This O work O was O supported O by O the O ‘Deutsche O Forschungsgemeinschaft’ O SCHU O 2927/3-1 I-AWARD to O Wiebke O Schuett O and O Simon O C. O Griffith O an O ARC O Future I-ORG Fellowship I-ORG Grant I-ORG to O Simon O C. O Griffith O FT130101253 O and O the O Joint B-ORG Degree I-ORG International I-ORG Macquarie I-ORG University I-ORG Research I-ORG Excellence I-ORG Scholarship I-ORG to O Caterina O Funghi O iMQRES O I-AWARD 2016204 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O Beijing B-ORG Postdoctoral I-ORG Research I-ORG Foundation I-ORG Grant O No. O ZZ2019-04 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81802550 B-AWARD and O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2019M660041 B-AWARD This O research O was O financially O supported O by O the O Sub-project B-ORG of I-ORG the I-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2017YFC050410501 O the O Special O Fund O for O Forestry B-ORG Scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG No. O 201404303-05 B-AWARD the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG of I-ORG China I-ORG 2015BAD07B30103 O the O Special O Fund O for O Forest B-ORG Scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Welfare I-ORG 201304216 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Wellcome B-ORG Trust O Grant/Award O Number O 11122/Z/18/Z B-AWARD Kidney B-ORG Research I-ORG UK, O Grant/Award O Number O SF1/2014 B-AWARD Horizon B-ORG 2020 I-ORG Framework I-ORG Programme O Grant/Award O Number O 825392 B-AWARD This O work O has O been O supported O in O part O by O the O Key B-ORG Program I-ORG of I-ORG Zhejiang I-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG LZ20H160001 O Key B-ORG Research I-ORG I-ORG Development I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2021C03126 O Medical B-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Key I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Provincial I-ORG Health I-ORG Commission I-ORG WKJ-ZJ-2007 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG 20JC1413800 O Zhejiang B-ORG Medical I-ORG and I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG 2022KY939 O and O Hangzhou B-ORG Medical I-ORG and I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG Z20210025 O and O 0020190490 B-AWARD Czech B-ORG Ministry I-ORG of I-ORG Education I-ORG LM2015047 O LM2015055 B-AWARD CZ.02.1.01/0.0/0.0/16_013/0001761 B-AWARD CZ.02.1.01/0.0/0.0/16_026/0008451 B-AWARD Raft4Biotech O and O SinFonia O from O the O European B-ORG Union I-ORG 720776 O 814418 B-AWARD The O MetaCentrum B-ORG and I-ORG CERIT-SC I-ORG are O acknowledged O for O providing O access O to O computing O facilities O LM2010005 O CZ.1.05/3.2.00/08.0144 B-AWARD Funding O for O open O access O charge O Czech O Ministry O of O Education O This O study O is O funded O by O the10.13039/100000865Bill O I-ORG Melinda I-ORG Gates I-ORG Foundation[OPP1084286 O OPP1117483 B-AWARD and10.13039/100004330GlaxoSmithKline[90063241 O EDM O was O also O supported O by O theFogarty O International I-ORG Center I-ORG of I-ORG the I-ORG National I-ORG Institutes I-ORG of I-ORG Healthunder O Award O Number O K01TW009988 B-AWARD for O the O research O reported O in O this O publication O The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O Bill O O Melinda O Gates O Foundation O GlaxoSmithKline O or O the O National O Institutes O of O Health O The O study O was O supported O by O research O grants O from O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG 2014CB541801 O National B-ORG key I-ORG research I-ORG and I-ORG development I-ORG program I-ORG 2016YFA0501303 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31521003 O 31630088 I-AWARD 31571293 O International B-ORG S&T I-ORG Cooperation I-ORG Program I-ORG of I-ORG China I-ORG 2013DFA30870 O 111 O Project O B13016 O Shanghai O Committee O of O Science O and O Technology O Funds O 17ZR1420200 O and O US O NIH O NIAID O U01 O 1U01AI090909 O Computational O support O was O provided O by O the O High-End O Computing O Center O located O at O Fudan O University O This O work O was O supported O by O the O Wellcome B-ORG Trust I-ORG WT098610 O who O funded O the O study O and O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O 098610/Z/12/Z O D.A.L O is O supported O by O the O Medical B-ORG Research I-ORG Council I-ORG MC_UU_12013/5 O and O by O the O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG NF-SI-0611–10196 O L.S O is O supported O by O a O Wellcome B-ORG Senior I-ORG Research I-ORG Fellowship I-ORG in I-ORG Clinical I-ORG Science I-ORG 098504/Z/12/Z O In O addition O to O the O International O Psoriasis O Council O funding O is O acknowledged O from O a O Medical O Research O Council O MRC O Stratified O Medicine O award O MR/L011808/1 O to O C.E.M.G O N.J.R O R.B.W O C.H.S O R.C.T O M.A.S O and O J.N.B O and O The O Psoriasis O Association O RG2/10 O S.K.M O was O funded O by O a O MRC O Clinical O Training O Fellowship O MR/L001543/1 O C.E.M.G O is O a O National O Institute O for O Health O Research O NIHR O Senior O Investigator O The O research O was O supported O by O the O NIHR O Biomedical O Research O Centre O based O at O Guy's O and O St O Thomas O NHS O Foundation O Trust O and O King's O College O London O and O by O the O NIHR O Biomedical O Research O Centre O at O South O London O and O Maudsley O NHS O Foundation O Trust O and O King's O College O London O The O views O expressed O are O those O of O the O authors O and O not O necessarily O those O of O the O NHS O NIHR O Department O of O Health O or O King's O College O London O We O gratefully O acknowledge O capital O equipment O funding O from O the O Maudsley B-ORG Charity I-ORG grant O 980 B-AWARD and O Guy's O and O St O Thomas's O Charity O grant O STR130505 O We O acknowledge O use O of O the O British O 1958 O Birth O Cohort O DNA O collection O funded O by O the O MRC O grant O G0000934 B-AWARD and O the O Wellcome B-ORG Trust I-ORG grant O 068545/Z/02 B-AWARD This O work O was O also O supported O by O the O German O Federal O Ministry O of O Education O and O Research O BMBF O within O the O framework O of O the O e:Med O research O and O funding O concept O sysINFLAME O grant O 01ZX1306A O The O project O received O infrastructure O support O from O the O DFG O Excellence O Cluster O No. O 306 O Inflammation O at O Interfaces O and O the O PopGen O Biobank O Kiel O Germany O grant O 01EY1103 O The O KORA O research O platform O KORA O Cooperative O Research O in O the O Region O of O Augsburg O was O initiated O and O financed O by O the O Helmholtz O Zentrum O München O – O German O Research O Center O for O Environmental O Health O which O is O funded O by O BMBF O and O by O the O State O of O Bavaria O Furthermore O KORA O research O was O supported O within O the O Munich O Center O of O Health O Sciences O MC O Health O Ludwig-Maximilians-Universität O as O part O of O LMUinnovativ O SHIP O Study O of O Health O in O Pomerania O is O part O of O the O Community O Medicine O Research O net O CMR O of O the O University O of O Greifswald O Germany O which O is O funded O by O BMBF O grants O 01ZZ9603 O 01ZZ0103 O and O 01ZZ0403 O and O the O Ministry O of O Cultural O Affairs O as O well O as O the O Social O Ministry O of O the O Federal O State O of O Mecklenburg-West O Pomerania O and O the O network O Greifswald O Approach O to O Individualized O Medicine O GANI_MED O funded O by O BMBF O grant O 03IS2061A O Exome O Chip O data O have O been O supported O by O BMBF O grant O no. O 03Z1CN22 O and O the O Federal O State O of O Mecklenburg-West O Pomerania O Parts O of O the O study O were O supported O by O the O BMBF O Metarthros O grant O 01EC1407A O to O A.R O and O U.H O A.F O receives O an O endowment O professorship O by O the O Foundation O for O Experimental O Medicine O Zürich O Switzerland O This O work O was O also O supported O by O awards O from O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG R01AR042742 O R01AR050511 B-AWARD R01AR054966 B-AWARD R01AR063611 B-AWARD R01AR065183 B-AWARD to O J.T.E O as O well O as O a O GAIN O award O from O the O Foundation O for O the O National O Institutes O of O Health O to O G.R.A O J.T.E O and O T.T O are O supported O by O the O Ann O Arbor O Veterans O Affairs O Hospital O J.E.G O is O supported O by O the O Taubman O Medical O Research O Institute O as O the O Frances O and O Kenneth O Eisenberg O Emerging O Scholar O Funding O to O pay O the O Open O Access O publication O charges O for O this O article O was O provided O by O the O International O Psoriasis O Council O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31572352 B-AWARD 41706153 B-AWARD 31771649 B-AWARD Qingdao B-ORG National I-ORG Laboratory I-ORG for I-ORG Marine I-ORG Science I-ORG and I-ORG Technology I-ORG QNLM2016ORP0301 O and O the O Taishan B-ORG Scholar I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG China I-ORG 201502035 O This O work O was O supported O by O grants O from O the B-ORG Scientific I-ORG Research I-ORG Fund I-ORG of I-ORG Hunan I-ORG Provincial I-ORG Education I-ORG Department I-ORG China I-ORG No. O 22A0188 B-AWARD Hunan B-ORG Provincial I-ORG University I-ORG Student I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Training I-ORG Program I-ORG 202210538006 O the O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG of I-ORG Hunan I-ORG Province I-ORG No. O 2020RC2059 B-AWARD the O Program B-ORG of I-ORG Hunan I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Team I-ORG No. O 2021RC4063 B-AWARD Scientific B-ORG Innovation I-ORG Fund I-ORG for I-ORG Talent I-ORG Introduction I-ORG of I-ORG Central I-ORG South I-ORG University I-ORG of I-ORG forestry I-ORG and I-ORG technology I-ORG 2018YJ011 O the O Scientific B-ORG Innovation I-ORG Fund I-ORG for I-ORG Post-graduates I-ORG of I-ORG Central I-ORG South I-ORG University I-ORG of I-ORG Forestry I-ORG and I-ORG Technology I-ORG CX20201009 O and O CX20202012 B-AWARD and O the O Hunan B-ORG Provincial I-ORG Innovation I-ORG Foundation I-ORG for I-ORG Postgraduate I-ORG CX20200695 O and O CX20200725 B-AWARD This O research O was O funded O by O ‘Science O and I-ORG Technology I-ORG Program I-ORG of I-ORG Suqian I-ORG H201709)’ O Shanghai B-ORG Leading I-ORG Academic I-ORG Discipline I-ORG Project I-ORG B502 O and O Shanghai B-ORG Key I-ORG Laboratory I-ORG Project I-ORG 08DZ2230500 O This O work O has O been O financially O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 61973127 B-AWARD Guangdong B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG Grant O No. O 2022A1515011416 B-AWARD and O Young B-ORG Scholars I-ORG Launching I-ORG Fund I-ORG Grant O No. O 10-00-309-008-01 B-AWARD This O project O was O supported O by O the O Project O of O Outstanding O Youth O Science O Foundation O of O China O 51425801 O Project O of O Chongqing O Science O and O Technology O Committee O cstc2015jcyjA00022 O Scientific B-ORG and I-ORG Technological I-ORG Research I-ORG Program I-ORG of I-ORG Chongqing I-ORG Municipal I-ORG Education I-ORG Commission I-ORG KJ1710237 O to O FL O Open B-ORG Foundation I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG Breeding I-ORG Base I-ORG of I-ORG Mountain I-ORG Bridge I-ORG and I-ORG Tunnel I-ORG Engineering I-ORG CQSLBF-Y16-6 O to O FL O Open B-ORG Foundation I-ORG of I-ORG Engineering I-ORG Research I-ORG Center I-ORG of I-ORG Bridge I-ORG Structure I-ORG and I-ORG Material I-ORG in I-ORG the I-ORG Mountainous I-ORG Area I-ORG Ministry I-ORG of I-ORG Education I-ORG QLGCZX-JJ2015-4 O to O FL O and O Disaster O Prevention O and O Disaster O Mitigation O and O Safety O of O Engineering O Structure O in O Three O Gorges O Reservoir O The O innovation O team O of O the O Chongqing O Education O Committee O CXTDX201601034 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O J.F O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81702455 O Y.Z O is O supported O by O the B-ORG Research I-ORG Special I-ORG Fund I-ORG for I-ORG Public I-ORG Welfare I-ORG Industry I-ORG of I-ORG Health I-ORG 201402008 O and O the B-ORG National I-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2014AA020610 O This O work O was O supported O by O the O Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG HRFRI I-ORG NO. O HSY201705M B-AWARD the O Special O Fund O for O Agro-scientific B-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG Grant O No. O 201203085 B-AWARD and O the O Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG CAFS I-ORG NO. O 2017HY-ZD1009 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O present O study O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81801727 O 81671712 B-AWARD and O 21807059 B-AWARD and O the O Ningxia B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2019BEG03018 O J. O Zhu O thanks O the O support O from O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20180711 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG for I-ORG Colleges I-ORG and I-ORG Universities I-ORG in I-ORG Jiangsu I-ORG Province I-ORG 17KJB350005 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81802299 O the O Chinese B-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG 2016-I2M-1-001 O 2017-I2M-1-005 O the B-ORG National I-ORG Key I-ORG Basic I-ORG Research I-ORG Development I-ORG Plan I-ORG 2018YFC1312105 O and O the O Beijing B-ORG Municipal I-ORG Science I-ORG I-ORG Technology I-ORG Commission I-ORG Z181100001918002 O DB, O CB, O BS, O SR O and O JB O were O supported O from O the O Deutsche B-ORG Forschungsgemeinschaft I-ORG DFG I-ORG within I-ORG the I-ORG Priority I-ORG Programme I-ORG DynaTrait I-ORG SPP O 1704 O grants O SU B-ORG 217/14-1 B-AWARD RA B-ORG 1898/1-1 B-AWARD and O BO B-ORG 3245/14-1 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O financially O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 31672414 B-AWARD 31272435 B-AWARD 31772588 B-AWARD the O Funds O of O Shandong“Double B-ORG Tops” I-ORG Program I-ORG SYL2017YSTD12 O and O Shandong B-ORG Agricultural I-ORG Breed I-ORG Project I-ORG 2019LZGC019 O The O funding O body O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81670159 O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG CIFMS O 2016-I2M-3-004 O Peking B-ORG Union I-ORG Medical I-ORG College I-ORG Youth I-ORG Fund I-ORG 2017320022 O This O research O was O funded O by O the O German B-ORG Research I-ORG Foundation I-ORG Deutsche O Forschungsgemeinschaft O Grant O No. O 1862/3-1 B-AWARD to O A.C O the O Hellenic B-ORG Foundation I-ORG for I-ORG Research I-ORG and I-ORG Innovation I-ORG 3222 O to O A.C O and O the O European B-ORG Research I-ORG Council I-ORG DEMETINL O to O T.C O This O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81771062 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG grant O number O 22Y21901000 B-AWARD and O the O Research B-ORG Discipline I-ORG fund I-ORG from I-ORG Shanghai I-ORG Ninth I-ORG People’s I-ORG Hospital I-ORG grant O number O KQYJXK2020 B-AWARD This O work O was O supported O by O the O Research B-ORG and I-ORG Innovation I-ORG Initiatives I-ORG of I-ORG WHPU I-ORG 2022Y16 O the O Scientific B-ORG Research I-ORG Foundation I-ORG of I-ORG Wuhan I-ORG Polytechnic I-ORG University I-ORG 118-53210052171 O 118-53210052144 B-AWARD and O 118-53210052136 B-AWARD and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2020YFE0205300 O This O work O was O supported O by O the O Sci-tech O Project O of O the O “12th O Five O year-plan” O of O China O 2010BACO1A11 O from O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG the I-ORG People's I-ORG Republic I-ORG of I-ORG China I-ORG http://www.most.gov.cn O granted O to O Congde O Huang O the O Crop O Breeding O Research O Project O of O the O “12th O Five-year-plan” O of O Sichuan O Province O 2011NZ0098-10 O form O the O Department B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Sichuan I-ORG Province I-ORG http://www.scst.gov.cn O granted O to O Congde O Huang O and O the O joint O Ph.D O program O grant O 201706910038 O from O the O China B-ORG Scholarship I-ORG Council I-ORG http://www.csc.edu.cn O granted O to O Shixing O Zhou O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81773620 O and O 81573332 B-AWARD 31872746 B-AWARD National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2015CB931800 O Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Funds I-ORG No. O 18431902800 B-AWARD The O authors O thank O USDA-ARS B-ORG Appropriated I-ORG Project I-ORG 5062-21220-021-00 B-AWARD USDA-ARS O National O Plant O Disease O Recovery O System O the O Durable O Rust O Resistance O in O Wheat O project O MNR O Saskatchewan B-ORG Agriculture I-ORG Development I-ORG Fund I-ORG project I-ORG 20080009 O CAM O Agriculture O and O Agri-Food O Canada O Growing O Forward O CWH O TF, O CAM O and O as O part O of O CTAG O a O Genome O Prairie O project O funded O by O Genome O Canada O Saskatchewan O Ministry O of O Agriculture O and O Western O Grain O Research O Foundation O CAM O for O financial O support O This O project O was O also O supported O through O a O grant O CIM/2007/084 B-AWARD provided O by O Australian B-ORG Centre I-ORG of I-ORG International I-ORG Agricultural I-ORG Research O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O No. O 81501431 B-AWARD 81874038 O 81771498 O 81600506 O 81671557 O 81672422 O and O 81721091 O National B-ORG S&T I-ORG Major I-ORG Project I-ORG of I-ORG China I-ORG grant O No. O 2018ZX10301201-008 B-AWARD 2017ZX10203205 B-AWARD and I-AWARD SQ2018YFC200043 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG grant O No.2017464 O Major B-ORG program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O No.91542205 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG grant O No.LY15H030012 O LY16H270001 O The O present O study O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81501359 B-AWARD and O No. O 81671553 B-AWARD Wuxi B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Fund I-ORG Project I-ORG CSE31N1713 O and O Wuxi B-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Committee I-ORG Youth I-ORG Project I-ORG Q201765 O The O funding O body O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81101483 O to O X. O Zhang O Program B-ORG for I-ORG New I-ORG Century I-ORG Excellent I-ORG Talents I-ORG in I-ORG University I-ORG NCET-11-0933 O to O X. O Zhang O Leader B-ORG talent I-ORG cultivation I-ORG plan I-ORG of I-ORG innovation I-ORG team I-ORG in I-ORG Hebei I-ORG province I-ORG LJRC001 O to O X. O Zhang O and O Leader B-ORG talent I-ORG cultivation I-ORG plan I-ORG of I-ORG innovation I-ORG team I-ORG in I-ORG Tangshan I-ORG city I-ORG 2060402 O to O X. O Zhang O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Natural B-ORG Science I-ORG Fund I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG of I-ORG Zhejiang I-ORG Province I-ORG LR22H260001 O XL O CRUK O Career B-ORG Development I-ORG Fellowship I-ORG C31250/A22804 O ET O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81970494 O and O Key B-ORG Project I-ORG of I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG of I-ORG Hunan I-ORG Province I-ORG 2019SK2041 O XYW O C.B O was O supported O by O the O Institut O National O de O la O Santé O et O de O la O Recherche O Médicale O Inserm O Plan O Cancer O O Formation O à O la O recherche O translationnelle O A.E O by O the O association O d’aide O en O Cancérologie O de O Saint-Cloud O ARCS O and O Y.K O by O the O Institut B-ORG National I-ORG du I-ORG Cancer O INCa O INCa-DGOS-9963 O INCa-11692 O SIRIC O INCa-DGOS-4654 O and O the O Fondation O pour O la O Recherche O Medicale O FRM O The O experimental O work O was O supported O by O grants O from O the O Ligue B-ORG Nationale I-ORG Contre I-ORG le I-ORG Cancer I-ORG Labelisation O Inserm O PC201317 O Institut B-ORG Curie I-ORG Incentive O and O Cooperative O Program O Tumor O Micro-environment O PIC B-AWARD TME/T-MEGA O PIC3i O CAFi O ICGex O ANR-10-EQPX-03 O SIRIC O INCa-DGOS-4654 O and O INCa O STROMAE O INCa-DGOS-9963 O CaLYS O INCa-11692 O INCa-DGOS-Inserm-12554 O F.M-G O acknowledges O both O the O Association O “Le O cancer O du O sein O Parlons-en” O and O the O Simone O and O Cino O del O Duca O Foundation O for O attribution O of O their O “Grand O Prix” O F.M-G O is O very O grateful O to O all O her O funders O for O providing O support O throughout O the O years O This O work O was O supported O by O the O Peking B-ORG University I-ORG School I-ORG and I-ORG Hospital I-ORG of I-ORG Stomatology I-ORG YS020218 O Beijing B-ORG Municipal I-ORG Science I-ORG I-ORG Technology I-ORG Commission I-ORG Z181100001618008 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81641034 O This O work O was O supported O by O the O China B-ORG Ocean I-ORG Mineral I-ORG Resources I-ORG Research I-ORG and I-ORG Development I-ORG Association I-ORG (DY135-B-01 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG (41776170 O and I-AWARD 41606145 O Scientific B-ORG Research I-ORG Foundation I-ORG of I-ORG Third I-ORG Institute I-ORG of I-ORG Oceanography I-ORG SOA O 2016039 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81773180 B-AWARD 21705127 B-AWARD 91853123 B-AWARD and O 81800655 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2019M653715 B-AWARD and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG Grant O No: O 2018JM7086074 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O grants O obtained O from O Specialized B-ORG Research I-ORG Fund I-ORG for I-ORG the I-ORG Doctoral I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG No.20110101110101 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 41676166 B-AWARD Specialized B-ORG Research I-ORG Fund I-ORG for I-ORG the I-ORG Doctoral I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG of I-ORG China I-ORG grant O number O 20134402110005 B-AWARD Guangdong B-ORG Specialized I-ORG Project I-ORG for I-ORG Discipline I-ORG Improvement I-ORG grant O number O 2012gjhz0008 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O authors O would O like O to O acknowledge O the O support O by O Czech B-ORG Science I-ORG Foundation I-ORG project O GA23-06369S B-AWARD and O Charles B-ORG University I-ORG UNCE/SCI/010 O SVV-2020-260590 B-AWARD PRIMUS/19/SCI/05 B-AWARD M. O Bartoš O acknowledges O the O support O by O the O ESF B-ORG under O the O project O CZ.02.2.69/0.0/0.0/20_079/0017436 B-AWARD The O study O was O conducted O at O the O CANAM B-ORG Centre O of O Accelerators O and O Nuclear O Analytical O Methods O infrastructure O LM B-AWARD 2015056 O This O publication O was O supported O by O OP B-ORG RDE I-ORG MEYS I-ORG Czech I-ORG Republic I-ORG under O the O project O CANAM B-AWARD OP, I-AWARD CZ.02.1.01/0.0/0.0/16_013/0001812 O The O scientific O results O were O obtained O with O the O support O of O the O GACR B-ORG Project O No. O 22-10536S B-AWARD and O the B-ORG University I-ORG of I-ORG J. I-ORG E. I-ORG Purkyne I-ORG project O UJEP-SGS-2021-53-005-2 B-AWARD The O present O work O was O financially O supported O by O the O Guangdong O Technological O Innovation O Strategy O of O Special O Funds O Key-Area O of I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province O grant O number O 2018B020205003 B-AWARD National O Key O R&D O Program O of O China O grant O number O 2018YFC1602500 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 31730070 B-AWARD and I-AWARD 31701195 O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG grant O number O 2017A070702018 B-AWARD GDAS’ B-ORG Special I-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG grant O number O 2017GDASCX-0201 B-AWARD and O the O 1000-Youth O Elite O Program O and O the O 111 O Project O The O funding O bodies O were O not O involved O in O the O design O of O the O study O and O collection O analysis O interpretation O of O data O and O writing O of O the O manuscript O This O study O was O funded O by O the O Chinese B-ORG State I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O No. O 81970798 B-AWARD National B-ORG Science I-ORG and I-ORG Technology I-ORG Key I-ORG R&D I-ORG Program I-ORG Grant O No. O 2019YFC0118402 B-AWARD Capital’s B-ORG Funds I-ORG for I-ORG Health I-ORG Improvement I-ORG and I-ORG Research I-ORG of I-ORG China I-ORG Grant O No. O CFH-2020-2-40911 B-AWARD Young B-ORG Scientists I-ORG Fund I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 82201180 B-AWARD and O the O Peking B-ORG University I-ORG Medicine I-ORG Fund I-ORG of I-ORG Fostering I-ORG Young I-ORG Scholars’ I-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG BMU2022PYB018 O The O study O was O supported O by O the O National O Institute O On O Aging O under O Award O Number O AG055184 B-AWARD and O by O CTSA O Award O Number O UL1TR002243 B-AWARD from O the O National B-ORG Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences O Dr. O Shoemaker O and O Dr. O Akers O are O supported O by O the O Strategically O Focused O Research O Network O Award O from O the O American B-ORG Heart I-ORG Association O 18SFRN34110369 B-AWARD REDCap O is O supported O in O part O by O the O National O Institutes O of O Health O NIH/NCATS O UL1 O TR000445 B-AWARD The O statements O in O this O work O are O solely O the O responsibility O of O the O authors O and O do O not O necessarily O represent O official O views O of O the O National B-ORG Institute I-ORG on I-ORG Aging O the O National O Center O for O Advancing O Translational O Sciences O the O National O Institutes O of O Health O or O the O American O Heart O Association O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O the O research O support O of O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81202459 O 21505009 O by O the O Chongqing B-ORG Graduate I-ORG Student I-ORG Research I-ORG Innovation I-ORG Project I-ORG CYB14027 O and O by O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG CDJZR14468801 O CDJKXB14011 I-AWARD 2015CDJXY O This O research O was O funded O by O the O Foundation B-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG FCT I-ORG Portugal I-ORG through I-ORG national I-ORG funds I-ORG FCT/MCTES I-ORG to I-ORG iMed.ULisboa I-ORG UIDP/04138/2020 O UIDB/04138/2020 B-AWARD and O MEtRICs B-ORG UIDP/04077/2020 O UIDB/04077/2020 B-AWARD research O projects O as O well O as O doctoral B-ORG scholarship I-ORG SFRH/BD/125310/2016 O granted O to O the O first O author O This O work O was O supported O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG http://www.nsfc.gov.cn O 31330061 O the B-ORG National I-ORG GMO I-ORG project I-ORG http://www.nmp.gov.cn/zxjs/200901/t20090113_2113.htm(2013ZX08009-003-001 O and O the B-ORG Shanghai I-ORG Committee I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG http://www.stcsm.gov.cn O 14JC1406700 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O Guangzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 3030901006039 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81570862 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2014A030313197 O The O funding O body O had O no O role O in O the O design O of O the O study O collection O analysis O interpretation O of O data O or O in O writing O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81702063 B-AWARD 81871703 B-AWARD the O Guangzhou B-ORG Science I-ORG Technology I-ORG and I-ORG Innovation I-ORG Commission I-ORG grant O number O 201707010296 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG grant O number O 2015A030310439 B-AWARD Guangdong B-ORG Provincial I-ORG Hospital I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG grant O number O YN2018QJ01 B-AWARD This O research O was O supported O by O the O Basic O Science O Research O Program O through O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O funded O by O the O Ministry O of O Education O Science O and O Technology O 2013068067 O and O by O the O Brain O Korea O 21 O Graduate O Programme O of O the O Korean O Ministry O of O Education O Science O and O Technology O Seoul O National O University O Hospital O the O Korean O Society O of O Hypertension O 2013 O the O SK B-ORG Telecom I-ORG Research I-ORG Fund I-ORG 3420130290 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 31460265 B-AWARD Funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20161380 O to O SX; O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31572151 O and O 31770387 B-AWARD to O RW; O the O Undergraduate B-ORG Training I-ORG Programs I-ORG for I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG of I-ORG Anhui I-ORG Province I-ORG S201910879203 O to O SY. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Yunnan B-ORG Science I-ORG and I-ORG Technology I-ORG Talent I-ORG and I-ORG Platform I-ORG Program I-ORG 2017HC019 O Yunnan B-ORG Joint I-ORG Support I-ORG for I-ORG National I-ORG Program I-ORG 2015GA009 O Yunnan B-ORG Province I-ORG Major I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 2017ZF007 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O U1702282 O The O funders O have O no O role O in O the O design O collection O analysis O interpretation O of O data O and O in O writing O the O manuscript O of O the O study O The O author(s O disclose O receipt O of O the O following O financial O support O for O the O research O authorship O and/or O publication O of O this O article O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 51808419 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2017M622540 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG WUT O 2019IVB064 B-AWARD 2018IVA008 O and O the O Major O Special O Research O and O Development O Programs O of O Hubei O Province O Grant O No. O 2018AAA001 O A.P O gratefully O acknowledges O the O INSPIRE O programme O Department O of O Science O and O Technology O Government O of O India O for O awarding O a O senior O research O fellowship O R.D.M O gratefully O acknowledges O a O national O postdoctoral O fellowship O from O SERB-India O U.H O gratefully O acknowledges O the O Council O of O Scientific O and O Industrial O Research O CSIR O of O the O Government O of O India O for O a O fellowship O S.G.R O acknowledges O the O Indian O Institute O of O Science O Education O and O Research O Kolkata O for O a O fellowship O W.L.L O gratefully O acknowledges O the O University O of O Wolverhampton O Early O Researcher O Award O Scheme O for O financial O support O J.G.H O gratefully O acknowledges O funding O from O the O Royal B-ORG Society I-ORG RG160449 O the O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG BBSRC O Networks O in O Industrial O Biotechnology O and O Bioenergy O NIBB O FoodWasteNet O FWN O grant O BB/L0137971/1 B-AWARD for O a O Proof O of O Concept O Grant O and O the O Engineering B-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG EPSRC O First O Grant O EP/R003823/1 O supporting O G.R.H O This O work O was O supported O by O a O Newton O Bhabha O PhD O Placement O Programme O grant O under O the O UK-India O Newton O Bhaba O Fund O Partnership O which O is O funded O by O the O UK O Department O of O Business O Energy O and O Industrial O Strategy O BEIS O the O Indian O Department O of O Science O and O Technology O DST O and O Department O of O Biotechnology O DBT O and O delivered O by O the O British O Council O The O APC O was O funded O by O Lancaster O University O This O research O was O funded O by O Key B-ORG Points I-ORG of I-ORG Natural I-ORG Science I-ORG in I-ORG Colleges I-ORG and I-ORG Universities I-ORG of I-ORG the I-ORG Anhui I-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG Nos O 2022AH052188 B-AWARD Research B-ORG Center I-ORG of I-ORG Environmental I-ORG monitoring I-ORG and I-ORG Control I-ORG Kjcxpt202004 O and O Academic B-ORG and I-ORG technical I-ORG leader I-ORG rc2021dtr06 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81891012 B-AWARD the O Chinese B-ORG Medicine I-ORG Science I-ORG and I-ORG Technology I-ORG Industry I-ORG Innovation I-ORG Team I-ORG Program I-ORG of I-ORG Sichuan I-ORG Province I-ORG grant O number O 2022C001 B-AWARD and O the O Chengdu B-ORG University I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG “Xinglin I-ORG Scholars” I-ORG Discipline I-ORG Talent I-ORG Research I-ORG Promotion I-ORG Program I-ORG grant O number O XCZX2022010 B-AWARD This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Project O no. O 81971753 B-AWARD Program B-ORG for I-ORG Medical I-ORG Key I-ORG Department I-ORG of I-ORG Shanghai I-ORG Grant O No. O ZK2019C01 B-AWARD The B-ORG Outstanding I-ORG Clinical I-ORG Discipline I-ORG Project I-ORG of I-ORG Shanghai I-ORG Pudong I-ORG Grant O No. O PWYgy2018-09 B-AWARD The B-ORG fund I-ORG of I-ORG Key I-ORG Disciplines I-ORG Group I-ORG Construction I-ORG Project I-ORG of I-ORG Pudong I-ORG Health I-ORG Bureau I-ORG of I-ORG Shanghai I-ORG Grant O No. O PWZxq2017-11 B-AWARD Program B-ORG for I-ORG Outstanding I-ORG Leader I-ORG of I-ORG Shanghai I-ORG Grant O No. O 046 B-AWARD This O work O was O supported O by O grant O 81430075 B-AWARD from O the O National B-ORG Natural I-ORG Science I-ORG Key I-ORG Foundation I-ORG of I-ORG China I-ORG Xiang O Chen O grant O 81620108024 B-AWARD from O International B-ORG Cooperation I-ORG and I-ORG Exchanges I-ORG National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Xiang O Chen O and O grant O 81572677 B-AWARD from O the O National O Natural O Science O Foundation O of O China O Weiqi O Zeng).http://www.nsfc.gov.cn O This O research O was O funded O by O the O Guizhou B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Project O grant O number O Qiankehe B-AWARD Support I-AWARD 2021 I-AWARD General I-AWARD 111 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 3226180451 B-AWARD Education B-ORG Department I-ORG of I-ORG Guizhou I-ORG Province I-ORG Scientific I-ORG Research I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG Institutions I-ORG Young O Scientific O Program O grant O number O Qianjiaoji B-AWARD 2022 I-AWARD No. I-AWARD 118 O Research B-ORG Funds I-ORG for I-ORG Introduced I-ORG Talents I-ORG of I-ORG Guizhou I-ORG University O grant O number O Guizhou B-AWARD University I-AWARD renjihezi I-AWARD 2021 I-AWARD No. I-AWARD 34. I-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81271489 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG No. O H2015206392 B-AWARD Government B-ORG Sponsored I-ORG Provincial I-ORG Clinical I-ORG Medicine I-ORG Talents I-ORG Program I-ORG No. O LS201605 B-AWARD and O Major B-ORG medical I-ORG research I-ORG projects I-ORG from I-ORG Health I-ORG Commission I-ORG of I-ORG Hebei I-ORG Province I-ORG No. O zd2013085 B-AWARD The O funders O have O no O roles O in O the O design O of O the O study O the O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 52278500 O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF-2021R1I1A2048618 O and O 2021R1C1C1010087 B-AWARD and O the O Research B-ORG Foundation I-ORG of I-ORG Education I-ORG Bureau I-ORG of I-ORG Hunan I-ORG Province I-ORG of I-ORG China I-ORG 21B0470 O 21A0293 B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31670074 O and O 21661140002 O the O 973 O program O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG China I-ORG 2015CB554202 O and O Shanghai B-ORG Science I-ORG I-ORG Technology I-ORG Specific I-ORG Projects I-ORG 124119a6100 O This O work O was O supported O by O the O Wellcome B-ORG Trust I-ORG through O a O Intermediate O Fellowship O in O Public O Health O and O Tropical O Medicine O to O FO O 102350 O This O work O was O also O supported O by O The O Engineering B-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG EPSRC O EP/J009733/1 O EP/K034995/1 B-AWARD EP/N508792/1 B-AWARD and O EP/N007417/1 B-AWARD and O Medical B-ORG Research I-ORG Council I-ORG MRC O MR/P025501/1 O FB O is O supported O by O an O AXA B-ORG Research I-ORG Fund I-ORG fellowship O 14-AXA-PDOC-130 O and O a O European O Molecular O Biology O Organization O EMBO O Long O Term O fellowship O 43-2014 O MV O is O funded O under O the O MRC/Department O for O International O Development O Concor-dat O agreement O which O is O part O of O EU O EDCTP2 O programme O MR/N015320/1 O This O research O was O funded O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Nos O 2017YFC0803506 B-AWARD 2017YFC0822003 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG China I-ORG Grant O No. O 2018JKF217 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 61503387 B-AWARD 61772539 O This O work O was O funded O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG #2016YFC0207000 O 2016 O the B-ORG Guangdong I-ORG Provincial I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG provided I-ORG financial I-ORG support I-ORG in I-ORG the I-ORG form I-ORG of I-ORG Natural I-ORG Science I-ORG Founding I-ORG #2014A050503027 O 2014 O and O the B-ORG Liaoning I-ORG Provincial I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG provided I-ORG financial I-ORG support I-ORG in I-ORG the I-ORG form I-ORG of I-ORG Natural I-ORG Science I-ORG Founding I-ORG #2013225049 O 2013 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 41305138 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2017M621700 B-AWARD and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No.2018YFC1507604 O This O work O was O supported O by O grants O from O Priority B-ORG of I-ORG Shanghai I-ORG key I-ORG discipline I-ORG of I-ORG medicine I-ORG 2017ZZ02020 O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2016YFC1306805 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81471359 O Shanghai B-ORG Science I-ORG and I-ORG technology I-ORG committee I-ORG 14411963400 O The O funder O had O no O role O in O the O design O collection O management O analysis O and O approval O of O manuscript O or O decision O to O submit O the O manuscript O for O publication O The O current O thesis O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81573650 O the O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Special I-ORG Foundation I-ORG of I-ORG China I-ORG 2015CB554405 O and O the O Chinese B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017M621041 O This O research O is O supported O by O Shandong B-ORG Province I-ORG Outstanding I-ORG Young I-ORG Scientists I-ORG Award I-ORG Fund I-ORG BS2014HZ022 O Shandong B-ORG Province I-ORG Natural I-ORG Science I-ORG Foundation I-ORG ZR2015DL001 O The O Foundation B-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Coal I-ORG Mine I-ORG Disaster I-ORG Dynamics I-ORG and I-ORG Control O Chongqing O University O No.2011DA105287-ZD201402 O Startup O Fund O Scientific O Research O Project O of O Qufu B-ORG Normal I-ORG University I-ORG BSQD20130102 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O Supported O by O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG No. O 2013B021800189 I-AWARD No. I-AWARD 2014A070713041 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.31500712 O and O the O Guangzhou B-ORG city-level I-ORG key I-ORG disciplines I-ORG and I-ORG specialties I-ORG of I-ORG Immunology I-ORG No. O B127007 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O theUK O Medical I-ORG Research I-ORG Council(MC_A060_5PR10 O We O are O very O grateful O to O all O the O patients O and O their O families O for O enabling O this O research O We O also O thank O Dr O Elisabeth O Murray O for O helpful O comments O and O Dr O Elias O Mouchlianitis O for O helping O with O data O collection O A.J.H O was O supported O in O part O by O theWellcome O Trust(204277/Z/16/Z O J.S.S O was O supported O in O part O by O a O Scholar O Award O from O theJames O S. I-ORG McDonnell I-ORG Foundationand O in O part O by O BBSRC O grant O number O BB/L02263X/1 B-AWARD The O full O data O and O analysis O scripts O are O available O here:http://www.mrc-cbu.cam.ac.uk/people/rik.henson/personal/data4papers O This O work O was O supported O by: O HM, O R01NS091075 B-AWARD National B-ORG Institute I-ORG of I-ORG Neurological I-ORG Disorders I-ORG and I-ORG Stroke I-ORG National I-ORG Institutes I-ORG of I-ORG Health,https://www.ninds.nih.gov O HM, O 17-00832 B-AWARD Canon B-ORG Medical I-ORG Systems I-ORG Corporation,https://global.medical.canon O JMD O KL2TR001413 B-AWARD National B-ORG Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences I-ORG National I-ORG Institutes I-ORG of I-ORG Health,https://ncats.nih.gov O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No O 2018YFB1105702 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 81971760 B-AWARD 81801845 B-AWARD Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Program O JCYJ20220531091802006 B-AWARD and O the O Shenzhen B-ORG Fundamental I-ORG Research I-ORG Program I-ORG Grant O No O JCYJ20190807160811355 B-AWARD This O study O was O supported O in O part O by O the O Core O Research O for O Evolutional O Science O and O Technology O CREST O programme O JPMJCR13W3 O from O the O Japan B-ORG Science I-ORG and I-ORG Technology I-ORG Agency I-ORG JST O to O S.M O the O Advanced B-AWARD Genome I-AWARD Research I-AWARD and I-AWARD Bioinformatics I-AWARD Study I-AWARD to I-AWARD Facilitate I-AWARD Medical I-AWARD Innovation I-AWARD from O Japan B-ORG Agency I-ORG for I-ORG Medical I-ORG Research I-ORG and I-ORG Development I-ORG AMED O to O S.M O the O Leading B-AWARD Advanced I-AWARD Projects I-AWARD for I-AWARD Medical I-AWARD Innovation I-AWARD LEAP I-AWARD from O AMED O to O M.H O a O Grant-in-Aid O for O Japan B-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG JSPS O Fellows O 267812 O to O S.N O and O a O Grant-in-Aid O for O JSPS O Research O Fellow O JP18J13422 O to O Y.S O Supercomputing O facilities O were O provided O in O part O by O the O Information O Technology O Center O and O the O Human O Genome O Center O of O The O University O of O Tokyo O This O study O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31330079 O 31672548 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0501305 O 2017YFD0500400 B-AWARD 2016YFD0500707 B-AWARD the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-35 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Henan I-ORG Province I-ORG 162300410129 O The O funding O body O was O solely O involved O in O funding O and O had O no O role O in O the O design O of O the O study O the O collection O analysis O and O interpretation O of O the O data O or O in O writing O the O manuscript O This O work O was O funded O by O U.S O National O Institutes O of O Health O NIH O National B-ORG Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute I-ORG Grant O R01-HL108927 B-AWARD NIH O National B-ORG Institute I-ORG of I-ORG Diabetes I-ORG and I-ORG Digestive I-ORG and I-ORG Kidney I-ORG Diseases I-ORG Grant O P30-DK065988 B-AWARD the O UK O Cystic B-ORG Fibrosis I-ORG Trust I-ORG INOVCF O SRC003 B-AWARD and O Cystic B-ORG Fibrosis I-ORG Foundation I-ORG Grants O R026-CR11 B-AWARD and O TARRAN17G0 B-AWARD The O authors O thank O FWO-Vlaanderen B-ORG https://www.fwo.be O for O the O research O grant O G0821.13 B-AWARD T.H O is O a O Ph.D O fellow O of O FWO-Vlaanderen O D.A.V O is O a O postdoctoral O fellow O supported O by O the O FWO O and O EU’s O Horizon B-ORG 2020 I-ORG research O and O innovation O programme O Marie O Skłodowska-Curie O Grant O Agreement O No. O 665501 B-AWARD https://ec.europa.eu/programmes/horizon2020 O H.V.O O acknowledges O that O the O research O leading O to O these O results O has O received O funding O from O the O European B-ORG Research I-ORG Council I-ORG under O the O European O Union’s O Seventh O Framework O Programme O FP7/2007–2013 O ERC O Grant O Agreement O No. O 308223 B-AWARD https://ec.europa.eu/research/fp7/index_en.cfm O P.V.L O would O like O to O acknowledge O the O support O by O BMBF O LiSym O https://www.bmbf.de O INSERM O –PhysiCancer O https://www.inserm.fr O ITMO O –INVADE O https://itcancer.aviesan.fr O EU O 7th O Framework O Programme O NOTOX O https://ec.europa.eu/research/fp7/index_en.cfm O and O ANR O –iLite O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG project O grant O number O 61672067 B-AWARD Beijing B-ORG Municipal I-ORG Natural I-ORG Science I-ORG Foundation I-ORG grant O number O KZ201710005005 B-AWARD and O the O International B-ORG Research I-ORG Cooperation I-ORG Seed I-ORG Fund I-ORG of I-ORG Beijing I-ORG University I-ORG of I-ORG Technology I-ORG grant O number O 2018B21 B-AWARD This O study O was O financially O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81372984 O and O the O Science O and O Technology O Innovation O Committee O of O Shenzhen O Municipality O JCYJ20170817094634747 O awarded O to O J.T O as O well O as O grants O from O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2016M602531 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017A030310140 O awarded O to O B.R O the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0505702 O Shanxi B-ORG Philosophy I-ORG and I-ORG Social I-ORG Sciences I-ORG Planning I-ORG Project I-ORG 2018B05 O and O Shanxi B-ORG Soft I-ORG Science I-ORG Research I-ORG Project I-ORG 2017041031-3 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O No. O 81874143 B-AWARD and O No. O 31971192 B-AWARD National B-ORG Key I-ORG Basic I-ORG Research I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O No. O 2014CBA02001 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Beijing I-ORG Municipality I-ORG grant O No. O 7192035 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Program O No. O 81801054 B-AWARD the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Program O No. O BK20180166 B-AWARD and O the B-ORG Wuxi I-ORG municipal I-ORG health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG Fund I-ORG Program O No. O Q201722 B-AWARD This O work O has O been O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31100522 B-AWARD National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2012AA020402 B-AWARD the O Special O Program O for O Applied O Research O on O Super B-ORG Computation I-ORG of I-ORG the I-ORG NSFC-Guangdong I-ORG Joint I-ORG Fund I-ORG the O second O phase O under O Grant O No. O U1501501 B-AWARD and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2016YXMS017 O The O funding O body O had O no O role O in O the O design O of O the O study O collection O analysis O or O interpretation O of O data O or O in O writing O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81500213 O the O Science B-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG of I-ORG Sichuan I-ORG Provincial I-ORG Education I-ORG Department I-ORG China I-ORG 17ZA0019 O the O Basic B-ORG and I-ORG Frontier I-ORG Research I-ORG Projects I-ORG of I-ORG Chongqing I-ORG China I-ORG cstc2014jcyjA10017 O and O the O Science B-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Chengdu I-ORG China I-ORG 2015-HM01-00032-SF O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grants O No. I-AWARD 51602200 I-AWARD 61874074 I-AWARD and I-AWARD 21603192 O Educational B-ORG Commission I-ORG of I-ORG Guangdong I-ORG Province I-ORG Grant O No. I-AWARD 2016KZDXM008 O and O the O Thousand O Young O Talents O Program O of O China O This O work O was O partially O supported O by O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG Grant O No. I-AWARD 2016B050501005 O the O Educational O Commission O of O Guangdong O Province O Grant O No. I-AWARD 2016KCXTD006 O the O China O Postdoctoral O Science O Foundation O Grant O No. O 2019M653006 O and O Shenzhen B-ORG Peacock I-ORG Plan I-ORG Grant O No. I-AWARD KQTD2016053112042971 O F.C O thanks O the O Outstanding O Young O Scholar O project O 8S0256 O from O South O China O Normal O University O for O its O support O The O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O T2288101 B-AWARD U2241273 B-AWARD 12172034 B-AWARD 11827803 B-AWARD U20A20390 B-AWARD Beijing B-ORG Municipal I-ORG Natural I-ORG Science I-ORG Foundation I-ORG 7212205 O the B-ORG 111 I-ORG project I-ORG B13003 O and O the O Fundamental O Research O Funds O for O the O Central O Universities O This O study O was O supported O mainly O by O grants O from O American B-ORG Heart I-ORG Association I-ORG Scientist O Development O Grant O 12SDG12050083 O to O G.D O National B-ORG Institute I-ORG of I-ORG Health I-ORG R21HL102773 O R21HD090680 B-AWARD R01HL118245 B-AWARD to O G.D O and O National B-ORG Science I-ORG Foundation I-ORG CBET-1263455 O CBET-1350240 O to O G.D O This O study O received O funding O from O the O Austrian B-ORG Science I-ORG Fund I-ORG grant O number O I4216 B-AWARD the O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG grant O number O 161787 B-AWARD the O Swedish B-ORG Research I-ORG Council I-ORG grant O number O 2018-00940 B-AWARD and O from O the O Portuguese O Foundation O for O Science O and O Technology O O FCT O grant O number O UIDB/04521/2020 O The O research O is O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0403302 O 2016YFD0200700 B-AWARD Support O also O came O from O the O Science B-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG of I-ORG Yangling I-ORG 2018GY-03 O and O the O Humanities B-ORG and I-ORG Social I-ORG Science I-ORG Program I-ORG of I-ORG Northwest I-ORG A&F I-ORG University I-ORG Z109021405 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG 2018YFE02013 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61873333 O Key B-ORG research I-ORG and I-ORG development I-ORG plan I-ORG of I-ORG Shandong I-ORG Province I-ORG 2019TSLH0301 O 2019GHZ004 B-AWARD The O article O publication O was O supported O by O National B-ORG Funds I-ORG through I-ORG FCT—Fundação I-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG a I-ORG Tecnologia I-ORG I.P O within O CINTESIS O R O O D O Unit O reference O UIDB/4255/2020 B-AWARD and O within O the O scope O of O the O project O RISE O Associated B-ORG Laboratory I-ORG reference O LA/P/0053/2020 B-AWARD ASB O acknowledges O FCT-supported B-ORG funds I-ORG from O UnIC@RISE O UIDB/00051/2020 O O UIDP/00051/2020 B-AWARD This O work O was O supported O by O Beijing B-ORG Hospitals I-ORG Authority I-ORG Youth I-ORG Programme I-ORG grant O number O QMS20180805 B-AWARD Cultivate B-ORG Foundation I-ORG of I-ORG Capital I-ORG Medical I-ORG University I-ORG grant O number O PYZ2018154 B-AWARD Top-notch B-ORG Youth I-ORG Project I-ORG of O the O Supporting O Plan O for O the O Construction O of O High-level O Teachers O in O Beijing-affiliated O Universities O grant O number O CIT&TCD201904093 B-AWARD Beijing B-ORG Municipal I-ORG Commission I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG grant O number O Z171100001017077 B-AWARD Beijing B-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospitals I-ORG Clinical I-ORG Medicine I-ORG Development I-ORG of I-ORG Special I-ORG Funding I-ORG Support I-ORG grant O number O XMLX201404 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by: O 1. O Foundation B-ORG for I-ORG the I-ORG National I-ORG Institutes I-ORG of I-ORG Health O Award O Number O R21 B-AWARD AI114259 O Recipient O Bettina O C. O Fries O 2. O Alpha B-ORG Omega I-ORG Foundation O Award O Number O Carolyn B-AWARD L. I-AWARD Kuckein I-AWARD Student I-AWARD Research I-AWARD Fellowship O Recipient O Natalie O A. O Mackow O and O 3. O Infectious B-ORG Diseases I-ORG Society I-ORG of I-ORG America O Award O Number O Medical B-AWARD Scholars I-AWARD Program O Recipient O Natalie O A. O Mackow O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O authors O gratefully O acknowledge O the O financial O support O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81771968 O No.81472842 O No.81560495 O and O No.81773222 O the O Shanghai B-ORG Municipal I-ORG Education I-ORG Commission-Gaofeng I-ORG Clinical I-ORG Medicine I-ORG Grant I-ORG Support O No.20181705 O and O the O Shanghai B-ORG Talent I-ORG Development I-ORG Fund I-ORG No.2017053 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31171608 O the O Special B-ORG Innovative I-ORG Province I-ORG Construction I-ORG in I-ORG Anhui I-ORG Province I-ORG 15czs08032 O the O Special B-ORG Project I-ORG for I-ORG Central I-ORG Guiding I-ORG Science I-ORG and I-ORG Technology I-ORG Innovatio I-ORG of I-ORG Region I-ORG in I-ORG Anhui I-ORG Province I-ORG 2016080503B024 O and O the O Programme B-ORG for I-ORG Changjiang I-ORG Scholars I-ORG and I-ORG Innovative I-ORG Research I-ORG Team I-ORG in I-ORG University I-ORG IRT1101 O Rebecca O E. O Hewitt O conducted O this O study O as O part O of O a O US B-ORG National I-ORG Science I-ORG Foundation I-ORG NSF I-ORG International I-ORG Research I-ORG Experience I-ORG for I-ORG Students I-ORG grant O OISE O 0854350 O to O Christopher O B. O Anderson O Further O support O to O Rebecca O E. O Hewitt O came O from O an O NSF B-ORG Graduate I-ORG Research I-ORG Fellowship I-ORG DGE-0639280 O and O 1242789 B-AWARD Alaska B-ORG EPSCoR I-ORG EPS-0701898 O as O well O as O from O the O Bonanza B-ORG Creek I-ORG Long-Term I-ORG Ecological I-ORG Research I-ORG NSF O DEB-1636476 I-AWARD and O USDA B-ORG Forest I-ORG Service I-ORG PNW I-ORG Research I-ORG Station I-ORG JVA-11261952-231 B-AWARD Lab O reagents O and O materials O were O funded O by O an O NSF O grant O ARC-0632332 O to O Donald O Lee O Taylor O and O by O the O University O of O North O Texas O Office O of O the O Vice-President O for O Research O to O Christopher O B. O Anderson O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O study O was O founded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 82004176 B-AWARD Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Sichuan I-ORG Province I-ORG China I-ORG Grant O No. O 2022YFS0251 B-AWARD Project B-ORG of I-ORG TCM I-ORG Administration I-ORG of I-ORG Sichuan I-ORG Province I-ORG Grant O No. O 2021MS451 B-AWARD Scientific B-ORG Research I-ORG Project I-ORG of I-ORG Sichuan I-ORG Maternal I-ORG and I-ORG Child I-ORG Health I-ORG Association I-ORG Grant O No. O 21FX02 B-AWARD Ministerio B-ORG de I-ORG Economía I-ORG y I-ORG Competitividad O AGL2014-54124R B-AWARD Consejo B-ORG Superior I-ORG de I-ORG Investigaciones I-ORG Científicas O 201540E084 B-AWARD Ministerio B-ORG de I-ORG Educación I-ORG Cultura I-ORG y I-ORG Deporte O FPU15/01630 B-AWARD This O work O was O supported O by O the B-ORG Youth I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Health I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Pudong I-ORG New I-ORG Area I-ORG Project O no. O PW2020B-5 B-AWARD the B-ORG Health I-ORG Industry I-ORG Clinical I-ORG Research I-ORG Project I-ORG of I-ORG Shanghai I-ORG Health I-ORG Commission I-ORG Project O no. O 20224Y0393 B-AWARD the B-ORG Outstanding I-ORG Clinical I-ORG Discipline I-ORG Project I-ORG of I-ORG Shanghai I-ORG Pudong I-ORG Grant O No. O PWYgy2021-04 B-AWARD the O Young B-ORG Medical I-ORG Talents I-ORG Training I-ORG Program I-ORG of I-ORG Pudong I-ORG Health I-ORG Committee I-ORG of I-ORG Shanghai I-ORG Grant O No. O PWRq B-AWARD 2021-08 O the O Outstanding B-ORG Leaders I-ORG Training I-ORG Program I-ORG of I-ORG Pudong I-ORG Hospital I-ORG affiliated I-ORG to I-ORG Fudan I-ORG University I-ORG Grant O No. O LX202201 B-AWARD the O Project B-ORG of I-ORG Key I-ORG Medical I-ORG Specialty I-ORG and I-ORG Treatment I-ORG Center I-ORG of I-ORG Pudong I-ORG Hospital I-ORG of I-ORG Fudan I-ORG University I-ORG Project O no. O Tszb2023-05 B-AWARD the O Talents B-ORG Training I-ORG Program I-ORG of I-ORG Pudong I-ORG Hospital I-ORG affiliated I-ORG to I-ORG Fudan I-ORG University I-ORG Project O no. O PX202001 B-AWARD and O the O Scientific B-ORG Research I-ORG Foundation I-ORG provided I-ORG by I-ORG Pudong I-ORG Hospital I-ORG affiliated I-ORG to I-ORG Fudan I-ORG University I-ORG Project O no. O YJRCJJ201906 B-AWARD This O work O was O supported O in O part O by O the O Department O for O the O Economy O Northern O Ireland O the O Cystic B-ORG Fibrosis I-ORG Foundation I-ORG WELDON18G0 O and O the O Rosetrees B-ORG Trust I-ORG A2450 O CT O and O SW O are O funded O by O the O Medical B-ORG Research I-ORG Council I-ORG MR/T016760/1 O and I-AWARD MR/P022847/1 O This O work O was O supported O by O the O Korea O Institute O of O Energy O Technology O Evaluation O and O Planning O KETEP O and O the O Ministry B-ORG of I-ORG Trade I-ORG Industry I-ORG I-ORG Energy I-ORG MOTIE I-ORG of I-ORG the I-ORG Republic I-ORG of I-ORG Korea O Grant O Number O 20163010012200 B-AWARD and O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O grant O funded O by O the O Korea O Government O MSIP O Grant O Number O 2018R1A2B2003826 B-AWARD This O study O also O received O partial O support O from O Korea B-ORG Electric I-ORG Power I-ORG Corporation I-ORG KEPCO O Grant O Number O O CX72170049 B-AWARD This O work O was O supported O by O the B-ORG National I-ORG High-tech I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2012AA02A510 O Beijing O China O the B-ORG Chinese I-ORG National I-ORG Nature I-ORG Science I-ORG Foundation I-ORG Grant O numbers O 81370219 B-AWARD and O 81400267 B-AWARD Beijing O China O and O the B-ORG Supporting I-ORG Project I-ORG of I-ORG Sichuan I-ORG Provincial I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Grant O numbers O 2012FZ0065 B-AWARD and O 2014SZ0004 B-AWARD Sichuan O China O This O work O was O supported O primarily O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81470461 O and O 81270251 B-AWARD to O Dr O Han O and O the B-ORG Scientific I-ORG fund I-ORG for I-ORG Outstanding I-ORG People I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG JC2016018 O to O Dr O Han).The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61572521 O the O Innovative B-ORG Research I-ORG Team I-ORG in I-ORG Engineering I-ORG University I-ORG of I-ORG People’s I-ORG Armed I-ORG Police I-ORG China I-ORG No. O KYTD201805 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG China I-ORG No. O 2021JM-252 O and O the O National B-ORG Social I-ORG Science I-ORG Fund I-ORG of I-ORG China I-ORG No. O 20XTQ007 O This O study O was O supported O by O research O grants O from O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2016A030313010 O 2018A030313506 B-AWARD The B-ORG Basic I-ORG Research I-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Innovation I-ORG Commission I-ORG of I-ORG Shenzhen I-ORG JCYJ20160429185525629 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shenzhen I-ORG University I-ORG General I-ORG Hospital I-ORG 0000040558 O This O trial O was O supported O by O grants O from O the B-ORG National I-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81572665 O 81172041 O 81472525 O the O International B-ORG Cooperation I-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2014A050503033 O 2016A050502011 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2013B021800141 O and O the O Foundation B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG of I-ORG Guangzhou I-ORG City I-ORG 2014Y2-00179 O The O first O five O funders O supported O the O design O of O the O study O and O data O collection O The O latter O two O funders O supported O data O analysis O and O manuscript O writing O This O project O was O funded O by O the O Czech B-ORG Science I-ORG Foundation I-ORG 16‐11164Y O the O Grant B-ORG Agency I-ORG of I-ORG the I-ORG Charles I-ORG University I-ORG GAUK O No. O 356217 B-AWARD and O the O Charles O University O PRIMUS/17/SCI/8 O and O UNCE204069 B-AWARD The O study O was O supported O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 3332021024 O the O Yunnan B-ORG Provincial I-ORG Cardiovascular I-ORG Disease I-ORG Clinical I-ORG Medical I-ORG Center I-ORG Project I-ORG FZX2019-06-01 O and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2022YFC2503402 O This O work O was O supported O by O The B-ORG European I-ORG Society I-ORG of I-ORG Contraception I-ORG and I-ORG Reproductive I-ORG Health I-ORG grant O no. O 8006970 B-AWARD Uppsala-Örebro B-ORG Regional I-ORG Research I-ORG Council I-ORG grant O no. O RFR B-AWARD 12712 O and O Uppsala B-ORG University I-ORG grant O no. O 464408792 B-AWARD The O funding O sources O were O not O involved O in O the O study O design O collection O analysis O and O interpretation O of O data O in O the O writing O of O the O report O or O in O the O decision O to O submit O the O article O for O publication O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG 2018YFE0182500 O the O foundation O of O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG via I-ORG Special I-ORG Research I-ORG Assistant I-ORG Program I-ORG No. O E20458YZ B-AWARD CAS B-ORG “Light I-ORG of I-ORG West I-ORG China” I-ORG Program I-ORG LICP I-ORG Cooperation I-ORG Foundation I-ORG for I-ORG Young I-ORG Scholars I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2022YFN0019 O and O the O scientific O research O programs O of O Shandong B-ORG Laboratory I-ORG of I-ORG Yantai I-ORG Advanced I-ORG Materials I-ORG and I-ORG Green I-ORG Manufacturing I-ORG E1R03SXM04 O and O AMGM2021A10 B-AWARD MG, O LG O and O HS O are O funded O by O the O Medical B-ORG Research I-ORG Council I-ORG MC_UU_12017/12 O O MC_UU_12017/13 B-AWARD and O the O Scottish O Government O Chief B-ORG Scientist I-ORG Office I-ORG SPHSU12 O O SPHSU13 B-AWARD MB O is O funded O by O the O Economic B-ORG and I-ORG Social I-ORG Research I-ORG Council I-ORG ES/N00812X/1 O These O funding O bodies O had O no O role O in O the O design O analysis O or O interpretation O of O the O study O or O in O writing O the O manuscript O Understanding O Society O is O an O initiative O funded O by O the O Economic O and O Social O Research O Council O and O various O Government O Departments O with O scientific O leadership O by O the O Institute O for O Social O and O Economic O Research O University O of O Essex O and O survey O delivery O by O NatCen O Social O Research O and O Kantar O Public O The O research O data O are O distributed O by O the O UK O Data O Service O SN O 6614 O This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFA0503800 O Ministry B-ORG of I-ORG Agriculture I-ORG of I-ORG the I-ORG People's I-ORG Republic I-ORG of I-ORG China I-ORG Grant O No. O 2016ZX08009003-003 B-AWARD and O the B-ORG Spanish I-ORG Ministry I-ORG of I-ORG Economy I-ORG MINECO I-ORG and I-ORG fondos I-ORG FEDER I-ORG grant O BIO2014 B-AWARD 57011-R O MN O is O a O Severo O Ochoa O postdoctoral O researcher O We O thank O Florian O Chevalier O and O Maryline O Liêvre O for O some O of O the O BRC1 O cDNA O clones O with O deletions O and O point O mutations O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81772639 B-AWARD 81672443 B-AWARD 81672960 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Beijing I-ORG No. O 7192157 B-AWARD the O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG CIFMS O No.2016-I2M-1-001 O and O the O Non-profit B-ORG Central I-ORG Research I-ORG Institute I-ORG Fund I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG No. O 2018PT32014 B-AWARD No. O 2018PT32002 B-AWARD Jiquan O Liu O is O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 31771072 B-AWARD The O URL O ishttp://www.nsfc.gov.cn O Jiquan O Liu O is O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O numbers O 2017YFC0114106 B-AWARD The O URL O ishttp://www.most.gov.cn/kjjh O Weiling O Hu O is O supported O by O Zhejiang B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG grant O numbers O LGF18H160012 B-AWARD The O URL O ishttp://www.zjkjt.gov.cn O The O research O leading O to O these O results O has O received O funding O from O the O European O Union’s O Seventh B-ORG Framework I-ORG Programme I-ORG FP7/2007–2013 O and O Horizon B-ORG 2020 I-ORG Framework O Programme O under O grant O agreements O No O 245058 B-AWARD and O No O 633571 B-AWARD respectively O and O from O the O Fundação B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG a I-ORG Tecnologia O through O the O research O unit O GREEN-IT O UID/Multi/04551/2013 O and O through O the O research O project O under O the O grant O agreement O no. O PTDC/AGR-ALI/099285/2008 B-AWARD MLA O and O MCVP O were O supported O by O Fundação O para O a O Ciência O e O a O Tecnologia O SFRH/BD/77723/2011 O FCT O Investigator O 2015 O contract O O IF/01337/2014 B-AWARD respectively O This O work O was O supported O by O the O National B-ORG Transgenic I-ORG Major I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016ZX08004001-006 B-AWARD the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG for I-ORG Crop I-ORG Breeding I-ORG No. O 2016YFD0102105 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Program I-ORG for I-ORG Innovation I-ORG Talents I-ORG of I-ORG Harbin I-ORG No. O 2014RFQYJ016 B-AWARD No. O 2014RFXYJ011 B-AWARD and O the O Project B-ORG of I-ORG Heilongjiang I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG HAAS O No. O 2017BZ12 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2018YFA0704200 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 51977204 B-AWARD U1832213 B-AWARD and O 51721005 B-AWARD the O Key B-ORG Research I-ORG Program I-ORG of I-ORG Frontier I-ORG Sciences I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG QYZDJ-SSW-JSC026 O and O the O International B-ORG Partnership I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Grant O No. O 182111KYSB20160014 B-AWARD This O trial O was O conducted O at O the O MRC O Epidemiology O Unit O in O Cambridge O UK. O It O was O funded O by O the O Medical B-ORG Research I-ORG Council I-ORG MC_U106179474 O the O Sixth B-ORG Framework I-ORG Programme I-ORG LSHM-CT-2006-037197 O and O the O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG RP-PG-0606-1259 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81672255 O Jiangsu B-ORG Higher I-ORG Institutions’ I-ORG Excellent I-ORG Innovative I-ORG Team I-ORG for I-ORG Philosophy I-ORG and I-ORG Social I-ORG Sciences I-ORG 2017STD006 O the O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG JX10231801 O and O the O Hospital B-ORG Construction I-ORG Fund I-ORG on I-ORG Key I-ORG Clinical I-ORG Specialty I-ORG of I-ORG the I-ORG Affiliated I-ORG Sir I-ORG Run I-ORG Run I-ORG Hospital I-ORG of I-ORG Nanjing I-ORG Medical I-ORG University I-ORG YFZDXK02-7 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O authors O are O grateful O for O the O funds O of O the O Jihua B-ORG Laboratory I-ORG Foundation I-ORG of I-ORG the I-ORG Guangdong I-ORG Province I-ORG Laboratory I-ORG of I-ORG China I-ORG X190071UZ190 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 62171142 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2021A1515011908 O the O Guangdong B-ORG Province I-ORG Key I-ORG Areas I-ORG R&D I-ORG Program I-ORG 2022B0303030002 O the O Guangdong O Province O Key O Areas O R&D O Program O 2020B0101320002 O the O Guangzhou B-ORG Key I-ORG R&D I-ORG Program I-ORG 202206030008 O the O International B-ORG Science I-ORG and I-ORG Technology I-ORG Cooperation I-ORG Project I-ORG of I-ORG Huangpu I-ORG 2021GH13 O and O GDAS’ B-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG 2022GDASZH-2022010108 O This O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O U1609209 B-AWARD 51375348 I-AWARD 71671130 O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG SZU I-ORG grant O number O 2017023 B-AWARD and O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Funds I-ORG grant O number O LR15E050003 B-AWARD LQ18F050006 O Guangdong B-ORG Innovation I-ORG Team I-ORG of I-ORG Seafood I-ORG Green I-ORG Processing I-ORG Technology I-ORG 2019KCXTD011 O Modern B-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG of I-ORG China I-ORG CARS-48 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Youth O Program O 32202086 O Scientific B-ORG and I-ORG Technological I-ORG Innovation I-ORG Strategy I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2022A05036 O Guangdong B-ORG General I-ORG Universities I-ORG Young I-ORG Innovative I-ORG Talents I-ORG Project I-ORG 2020KQNCX028 O General B-ORG transfer I-ORG payment I-ORG fund I-ORG project I-ORG of I-ORG fishery I-ORG development I-ORG support I-ORG policy I-ORG in I-ORG Guangdong I-ORG Province I-ORG in O 2022 O 2022-440000-45060100-9680 O This O work O was O supported O by O Development B-ORG Program I-ORG for I-ORG Basic I-ORG Research I-ORG of I-ORG China I-ORG 2013CB967402 O Longhua B-ORG Medical I-ORG Project I-ORG of I-ORG State I-ORG Clinical I-ORG Research I-ORG Center I-ORG of I-ORG TCM I-ORG in I-ORG Longhua I-ORG Hospital I-ORG LYTD-21 O and O JDZX2012123 B-AWARD and O State B-ORG Key I-ORG and I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 91229123 O and O 91019004 B-AWARD This O work O was O supported O by O the O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 3172404 O the B-ORG earmarked I-ORG fund I-ORG for I-ORG Shandong I-ORG Modern I-ORG Agro-Industry I-ORG Technology I-ORG Research I-ORG System I-ORG SDAIT-14 O and O Seed B-ORG Project I-ORG of I-ORG Shandong I-ORG Province I-ORG 2017LZGC009 O The O funding O bodies O did O not O contribute O to O the O design O of O the O study O sample O collection O analysis O interpretation O of O data O or O in O writing O the O manuscript O The O Spanish B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Innovation I-ORG Grant O TIN2011-27479-C04-01 B-AWARD the O Government B-ORG of I-ORG Aragón I-ORG and I-ORG the I-ORG European I-ORG Social I-ORG Fund I-ORG Grupo O consolidado I-AWARD T27 I-AWARD GISED O the O Spanish B-ORG Ministry I-ORG of I-ORG Education I-ORG FPU O AP2010-1058 O the O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III I-ORG FIS-PI14/00070 O the O Departamento B-ORG de I-ORG Ciencia I-ORG Tecnología I-ORG y I-ORG Universidad I-ORG of I-ORG the I-ORG Government I-ORG of I-ORG Aragón I-ORG Grupo O consolidado I-AWARD B33 O and O FEDER B-AWARD Funding I-AWARD Program I-AWARD from O the O European B-ORG Union O CIBERER O is O an O initiative O of O the O Instituto O de O Salud O Carlos O III O This O research O was O funded O by O the O Natural B-ORG Sciences I-ORG and I-ORG Engineering I-ORG Research I-ORG Council I-ORG NSERC I-ORG of I-ORG Canada I-ORG through I-ORG NSERC I-ORG Discovery I-ORG Grants I-ORG RGPIN-04945-2017 O and O RGPIN-05669-2020 B-AWARD Agriculture B-ORG and I-ORG Agri-Food I-ORG Canada I-ORG AgriScience I-ORG BioProducts I-ORG Cluster I-ORG Grant I-ORG ASC-03 O D. O Levin O and O through O the O Canada B-ORG Research I-ORG Chairs I-ORG Program I-ORG Grant O No. O 950-231971 B-AWARD to O N. O Budisa O We O gratefully O acknowledge O the O support O of O the O TU O Berlin O Open O Access O Publication O Fund O This O study O was O supported O by O grants O from O the O National B-ORG Health I-ORG Research I-ORG Institute I-ORG NHRI-EX107-10736SI O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Taiwan I-ORG 106-2314-B-182A-141 O MY3 O and O Chang B-ORG Gung I-ORG Memorial I-ORG Hospital O Taiwan O CMRPG8G1341 O and O 8F1562 B-AWARD However O these O organizations O had O no O part O in O the O study O design O data O collection O and O analysis O publication O decisions O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Chinese B-ORG National I-ORG Programs I-ORG for I-ORG Brain I-ORG Science I-ORG and I-ORG Brain-like I-ORG Intelligence I-ORG Technology I-ORG grant O number O 2021ZD0200800 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81971254 B-AWARD 81771440 B-AWARD Shanghai B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG grant O number O 2017SHZDZX01 B-AWARD the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG grant O number O 2016YFC1306800 B-AWARD 2016YFC1306900 B-AWARD and O the O Interdisciplinary B-ORG Program I-ORG of I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG grant O number O ZH2018ZDA40 B-AWARD This O study O gain O the O funding O support O of O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No O 70973025 B-AWARD Shanghai B-ORG Public I-ORG Health I-ORG Key I-ORG Discipline I-ORG Construction I-ORG Project-Health I-ORG Economics I-ORG No O 12GWZX0601 O Shanghai B-ORG Public I-ORG Health I-ORG Senior I-ORG Professional I-ORG Oversea I-ORG Fellowship I-ORG GWHW2012S10 O and O Shanghai B-ORG Public I-ORG Health I-ORG Excellent I-ORG Discipline I-ORG Leadership I-ORG Program I-ORG GWDTR201205 O This O research O was O funded O by O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31870333 O Qinghai O Province O International O Cooperation O Project O 2018-HZ-812 O Qinghai O Province O Applied O Basic O Research O Project O 2020-ZJ-905 O Qinghai O Province O Major O Science O and O Technology O Project O 2020-SF-A2 O Shandong B-ORG Provincial I-ORG Science I-ORG Foundation I-ORG ZR2017MH024 O Qinghai O Province O High-end O Innovative O Thousand O Talents O Program O and O Youth B-ORG Innovation I-ORG Promotion I-ORG Association O CAS B-AWARD This O study O was O funded O by O two O Innovational B-ORG Research I-ORG Incentives I-ORG Scheme I-ORG Vidi I-ORG grants O from O the O Netherlands O Organisation O for O Health O Research O and O Development O ZonMw O 91714371 I-AWARD to O C.A.R O and O ZonMw B-AWARD 016.146.310 I-AWARD to O J.R.G O a O ZonMw B-ORG Priority I-ORG Medicines I-ORG PM-Rare I-ORG grant I-ORG 113303006 O to O C.A.R O the B-ORG Netherlands I-ORG CardioVascular I-ORG Research I-ORG Initiative I-ORG CVON I-ORG Dutch O Heart O Foundation O Dutch O Federation O of O University O Medical O Centres O ZonMw O and O the O Royal O Netherlands O Academy O of O Sciences O PREDICT2 O CVON2018-30 I-AWARD to O C.A.R O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81071639 O and O the O Program B-ORG for I-ORG Changjiang I-ORG Scholars I-ORG and I-ORG Innovative I-ORG Research I-ORG Team I-ORG in I-ORG University I-ORG IRT0935 O and O also O by O the O Applied B-ORG and I-ORG Basic I-ORG Research I-ORG Project I-ORG of I-ORG Sichuan I-ORG Province O China O 2015JY0044 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81772338 O 81572122 B-AWARD the O Shanghai B-ORG Leading I-ORG Talent I-ORG Plan I-ORG 043 O and O the O Interdisciplinary B-ORG Program I-ORG of I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG YG2017ZD05 O This O research O was O funded O by O Tianjin B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG 22YFFCYS00060 O Central-Guided B-ORG Local I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Fund I-ORG Projects I-ORG 22ZYCGSN00110 O and O Beijing B-ORG Postdoctoral I-ORG Research I-ORG Foundation I-ORG 2022-ZZ-121 O This O study O was O supported O by O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG 2017-I2M-3-007 O The B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFA0101000 O 2016YFA0101003 O Beijing B-ORG Key I-ORG Laboratory I-ORG of I-ORG New I-ORG Drug I-ORG Development I-ORG and I-ORG Clinical I-ORG Trial I-ORG of I-ORG Stem I-ORG Cell I-ORG Therapy I-ORG BZ0381 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81473450 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O No.61803077 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG under O Grant O No.F2016501080 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG under O Grant O No. O N172304024 B-AWARD This O research O was O funded O by O the B-ORG Department I-ORG of I-ORG Education I-ORG of I-ORG Anhui I-ORG Province I-ORG of I-ORG China I-ORG KJ2019A0470 O KJ2020A0222 B-AWARD KJ2019A0943 B-AWARD KJ2019A0946 B-AWARD KJ2021A1227 B-AWARD the O Research O and O development O project O entrusted O by O the O enterprise O research B-ORG on I-ORG antioxidant I-ORG biological I-ORG activity I-ORG of I-ORG quercetin I-ORG 2022HZ049 O the B-ORG Quality I-ORG Engineering I-ORG Project I-ORG of I-ORG the I-ORG Anhui I-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG in O 2021 O 2021jyxm0824),the O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Province I-ORG of I-ORG China I-ORG 1608085MH227 O the B-ORG Quality I-ORG Engineering I-ORG Project I-ORG of I-ORG Anhui I-ORG University I-ORG of I-ORG Chinese I-ORG Medicine I-ORG in O 2021 O 2021zlgc042 O and O the B-ORG Anhui I-ORG University I-ORG of I-ORG Chinese I-ORG Medicine I-ORG annual I-ORG innovation I-ORG training I-ORG program I-ORG for I-ORG College I-ORG Students I-ORG 2017142 O 2017171 B-AWARD This O work O was O supported O by O the O Fundamental O Research O Funds O for O Industry-University-Research B-ORG in I-ORG Hefei I-ORG University I-ORG of I-ORG Technology I-ORG XC2016JZBZ03 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG JZ2017HGTA0228 O the B-ORG innovation I-ORG Project I-ORG for I-ORG College I-ORG Students I-ORG 2017CXCYS235 O Wanjiang B-ORG Institute I-ORG of I-ORG Poultry I-ORG Technology I-ORG XC2015AKKG002 O and O the O Science B-ORG and I-ORG Technology I-ORG Bureau I-ORG of I-ORG AnHui I-ORG XC2015XKKJ02 O XC2015AKKG003 B-AWARD This O study O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFC1200500 O the B-ORG Fourth I-ORG Round I-ORG of I-ORG Three-Year I-ORG Public I-ORG Health I-ORG Action I-ORG Plan I-ORG of I-ORG Shanghai I-ORG China I-ORG No. O 15GWZK0101 O and O the O Science B-ORG and I-ORG Technology I-ORG Plan I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG Jiangxi I-ORG Province I-ORG No. O 20172002 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 32260653 B-AWARD Top B-ORG Technology I-ORG Talent I-ORG Project I-ORG from I-ORG Guizhou I-ORG Education I-ORG Department I-ORG of I-ORG China I-ORG Grant O No. O Qian B-AWARD jiao I-AWARD ji I-AWARD 2022]074 O Guizhou B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG of I-ORG China I-ORG Grant O No. O ZK B-AWARD 2021]142 O Talent B-ORG Introduction I-ORG Research I-ORG Project I-ORG of I-ORG Guizhou I-ORG University I-ORG of I-ORG China I-ORG Grant O No. O 2020]35 B-AWARD Cultivation B-ORG Project I-ORG of I-ORG Guizhou I-ORG University I-ORG of I-ORG China O Grant O No. O 2020]24 B-AWARD and O Grant O No. O 2019]13 B-AWARD and O Key B-ORG research I-ORG and I-ORG development I-ORG projects I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG Grant O No. O 2021YFD1601000 B-AWARD This O study O was O financially O supported O by O grants O BTPR8501 O and I-AWARD BTPR9389 O from O the O Department B-ORG of I-ORG Biotechnology I-ORG Govt I-ORG of I-ORG India I-ORG to O PG, O and O grants O from O the O American B-ORG Heart I-ORG Association I-ORG SDG O 0635155N O and O the O National B-ORG Institute I-ORG of I-ORG Health I-ORG USA I-ORG HL095676 O to O YP. O This O study O has O received O funding O from O the O Beijing B-ORG Scholar I-ORG 2015 B-AWARD Zhenchang O Wang O Beijing B-ORG Key I-ORG Clinical I-ORG Discipline I-ORG Funding I-ORG No. O 2021-135 O and O Capital's B-ORG Funds I-ORG for I-ORG Health I-ORG Improvement I-ORG and I-ORG Research I-ORG No. O 2022-1-1111 I-AWARD This O work O was O supported O by O grants O from O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973Program O Grant O No. O 2014CB965000 O project O 1 O No. O 2014CB965001 B-AWARD and O project O 3 O No. O 2014CB965003 B-AWARD Innovative B-ORG Research I-ORG Groups I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81221001 O to O JZ O the O National O Natural O Science O Foundation O of O China O 81401704 O to O YL O Joint B-ORG Research I-ORG Fund I-ORG for I-ORG Overseas I-ORG Chinese I-ORG Hong I-ORG Kong I-ORG and I-ORG Macao I-ORG Young I-ORG Scientists I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG #81329002 O to O JZ O National B-ORG Institutes I-ORG of I-ORG Health O 2R56NS041858-15A1 O JZ O 1R01NS097195-01 B-AWARD JZ O and O R03 B-AWARD NS094071-01 I-AWARD YH O Shanghai B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG 20134y159 O to O YL O and O Yingcai B-ORG Plan I-ORG of I-ORG Tongji I-ORG University I-ORG 1500219116 O to O YL O This O review O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG Grant O No. O 2014FWPT07 B-AWARD the O Wuzhong B-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Talent I-ORG Project I-ORG of I-ORG Suzhou I-ORG Grant O No. O WC201526 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81270348 B-AWARD The O work O was O supported O by O grants O from O the O Modern B-ORG Agricultural I-ORG Industrial I-ORG System I-ORG Special I-ORG Funding I-ORG grant O numbers O CARS-44-A-1 B-AWARD Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG grant O numbers O PAPD B-AWARD 2014-134 O and O General O Program O of O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Higher I-ORG Education I-ORG Institutions I-ORG of I-ORG Jiangsu I-ORG Province I-ORG 16KJB230001 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O Spanish B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Innovation I-ORG MICINN O the B-ORG Carlos I-ORG III I-ORG Health I-ORG Institute/European I-ORG Regional I-ORG Development I-ORG Fund I-ORG ERDF O MICINN O ISCIII/FEDER O Red O RedIAPP I-AWARD RD06/0018 I-AWARD Research I-AWARD Groups I-AWARD RD16/0007/0003 I-AWARD RD16/0007/0004 I-AWARD RD16/0007/0008 O the O Health O Research O Fund O PI10/01088 O PI10/02077 I-AWARD PI10/02043 O PI13/01930 B-AWARD and O the O Regional B-ORG Health I-ORG Management I-ORG of I-ORG Castile I-ORG and I-ORG León I-ORG GRS O 635/A/11 O GRS B-AWARD 906/B/14 O This O work O was O supported O by O a O Sichuan B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG 2016SZ0010 O DS O received O fellowship O support O from O the O China B-ORG Scholarship I-ORG Council I-ORG 201708210187 O HY O is O a O postdoctoral O 11.N3.615N O and O JVD O is O a O predoctoral O 11.ZU.117N O FWO-research B-ORG fellow O The O present O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG No. O 18ZR1437000 B-AWARD the O Shanghai B-ORG Pujiang I-ORG Program I-ORG No. O 16PJC076 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 31371056 B-AWARD 31470051 I-AWARD 31701041 O the O Shanghai B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning—China I-ORG ZHYY-ZXYJHZX-2-22 O and O the O Shanghai B-ORG City I-ORG Committee I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Key I-ORG Project I-ORG No. O 17080503200 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Project O No. O 32170004 B-AWARD U2102220 B-AWARD Yunnan B-ORG Fundamental I-ORG Research I-ORG Project I-ORG Grant O No. O 202001AS070043 B-AWARD and O High-level B-ORG Talents I-ORG Program I-ORG of I-ORG Yunnan I-ORG Province I-ORG YNQR-QNRC-2018-111 O and O the O Science B-ORG Foundation I-ORG of I-ORG Education I-ORG Department I-ORG of I-ORG Yunnan I-ORG Province I-ORG 2023Y0724 O This O work O was O supported O by O the O College B-ORG Students’ I-ORG Scientific I-ORG Research I-ORG Fund I-ORG of I-ORG Wannan I-ORG Medical I-ORG College I-ORG grant O number O WK2014S28 B-AWARD University B-ORG Student I-ORG Innovative I-ORG Entrepreneurship I-ORG Training I-ORG Project I-ORG of I-ORG Anhui I-ORG Province I-ORG grant O number O 201410368067 B-AWARD 201510368036 B-AWARD Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Anhui I-ORG Province I-ORG of I-ORG China I-ORG grant O number O 1704a0802154 B-AWARD This O work O was O supported O by O Chinese B-ORG Cassava I-ORG Agro-technology I-ORG Research I-ORG System I-ORG CARS-11-YNSJ O Yunnan B-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Biological I-ORG Big I-ORG Data I-ORG 2018DG024 O and O the O Science B-ORG and I-ORG Technology I-ORG Plan I-ORG Projects I-ORG of I-ORG Yunnan I-ORG Province I-ORG 2016FD024 O Shanghua O Zheng O acknowledges O support O from O the O National B-ORG Science I-ORG Foundation I-ORG of O US O grant O no. O DMS O 1001855 B-AWARD Li O Guo O acknowledges O support O from O the O Engineering B-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG of O UK O grant O no. O EP/I037474/1 B-AWARD and O the O Austrian B-ORG Science I-ORG Fund I-ORG grant O no. O P30052 B-AWARD Markus O Rosenkranz O acknowledges O support O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 11601199 B-AWARD and O the O Foundation B-ORG of I-ORG Jiangxi I-ORG Provincial I-ORG Education I-ORG Department I-ORG grant O no. O GJJ160336 B-AWARD This O work O was O supported O by O the O Beijing O Advanced O Innovation O Center O for O Food O Nutrition O and O Human O Health O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31970717 O 82170429 O the O Chinese B-ORG Universities I-ORG Scientific I-ORG Fund I-ORG 2020TC015 O and O the O Beijing B-ORG Municipal I-ORG Natural I-ORG Science I-ORG Foundation I-ORG 7222111 O This O research O was O supported O by O the B-ORG National I-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF I-ORG funded O by O the O Ministry O of O Science O ICT O O Future O Planning O 2015R1C1A1A01051769 O by O the O Basic B-ORG Science I-ORG Research I-ORG Program I-ORG through I-ORG the I-ORG National I-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF I-ORG funded I-ORG by I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG ICT I-ORG and I-ORG future I-ORG Planning I-ORG 2016R1A2B4007870 O by O the B-ORG Pioneer I-ORG Research I-ORG Center I-ORG Program I-ORG through O the O National O Research O Foundation O of O Korea O funded O by O the O Ministry O of O Science O ICT O Future O Planning O 2014M3C1A3053036 O and O by O a O grant O of O the O Korea O Health O Technology O R&D O Project O through O the B-ORG Korea I-ORG Health I-ORG Industry I-ORG Development I-ORG Institute I-ORG KHIDI O funded O by O the O Ministry O of O Health O O Welfare O Republic O of O Korea O grant O number O HI14C2084 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O National B-ORG Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute I-ORG provided O funding O for O the O OPACH O study O grant O number O RO1 B-AWARD HL105065 I-AWARD to O AZL O Funding O also O came O from O a O training O grant O provided O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG grant O numbers O T32HL079891 B-AWARD to O JB O The O Women’s O Health O Initiative O program O was O funded O by O the O National O Heart O Lung O and O Blood O Institute O National O Institutes O of O Health O US O Department O of O Health O and O Human O Services O contract O numbers O HHSN268201600018C B-AWARD HHSN268201600001C I-AWARD HHSN268201600002C I-AWARD HHSN268201600003C I-AWARD and I-AWARD HHSN268201600004C O The O current O analysis O was O partially O funded O by O a O program O project O grant O supported O by O the O National B-ORG Institute I-ORG on I-ORG Aging I-ORG 1P01AG052352-01A1 O PI O AZL O All O funding O agencies O had O no O role O in O the O design O of O the O study O and O collection O analysis O or O interpretation O of O data O and O and O no O role O in O writing O the O manuscript O This O study O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0500602 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31570470 O 31870456 O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2412018ZD010 O and O the B-ORG Program I-ORG of I-ORG Introducing I-ORG Talents I-ORG of I-ORG Discipline I-ORG to I-ORG Universities I-ORG B16011 O to O WS. O This O work O was O supported O by O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo I-ORG O FAPESP O Grant O 2017/26872-5 B-AWARD to O CDG O and O 2016/02012-4 B-AWARD to O SMO O and O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG O CNPq O Grant O 308144/2014-7 B-AWARD to O SMO O Brazil O ADG O was O supported O by O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG – O CAPES O Finance O Code O 001 B-AWARD This O work O was O supported O by O the O British B-ORG Heart I-ORG Foundation I-ORG BHF O RG/12/10/29802 I-AWARD C.H.O O A.F.J O and O M.B.C O PG/14/65/31055 B-AWARD C.H.O O A.F.J O and O grants O from O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH O HL091071 I-AWARD H.H.P O HL107200 B-AWARD H.H.P O and O D.M.R O HL066941 B-AWARD H.H.P O and O D.M.R O HL115933 B-AWARD H.H.P O and O D.M.R O AG052722 B-AWARD H.H.P O and O the O Veterans B-ORG Affairs I-ORG Administration I-ORG VA O Merit O BX001963 B-AWARD H.H.P O and O BX000783 B-AWARD D.M.R. O This O work O was O supported O by O the O funding O from O National B-ORG Key I-ORG Research I-ORG Program I-ORG Contract O No.2016YFA0501703 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31601074 B-AWARD 61872094 B-AWARD 61832019 B-AWARD and O Shanghai B-ORG Jiao I-ORG Tong I-ORG University I-ORG School I-ORG of I-ORG Medicine I-ORG Contract O No. O YG2017ZD14 B-AWARD This O research O was O funded O by O National O key O R O O D O Program O of O China O grant O number O 2018YFD0901003 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province O grant O number O ZR201807110008 B-AWARD Shandong O Provincial O Key O R O O D O Program O grant O number O 2017GHY15128 O China B-ORG Agriculture I-ORG Research I-ORG System O grant O number O CARS-46 B-AWARD Jiangsu B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Program O grant O number O LYG-SZ201815 B-AWARD This O study O was O supported O by O the O grants O from O the O Luxembourg O Centre O for O Systems O Biomedicine O and O the O University O of O Luxembourg O Genetics B-ORG of I-ORG Prion I-ORG Susceptibility I-ORG in I-ORG vitro I-ORG NIH O P01 I-AWARD NS041997 O Center B-ORG for I-ORG Systems I-ORG Biology I-ORG NIH O 2P50GM076547-06A O DOD O Awards O W911NF-10-2-0111 O W81XWH-09-1-0107 O and O DAMD17–03-1-0321 O and O the O Institute B-ORG for I-ORG Basic I-ORG Science I-ORG IBS-R013-A1 O from O Korean O Ministry O of O Science O and O ICT O This O work O was O supported O by O Special B-ORG Research I-ORG Projects I-ORG of I-ORG Education I-ORG Department I-ORG of I-ORG Shaanxi I-ORG provincial I-ORG Government I-ORG no. O 15JK1782 B-AWARD ‘Cyanine O Talent’ O of O Xianyang O Normal O College O no. O XSYQL201710 O Innovative O Entrepreneurship O Training O Program O for O College O Students O of O Shannxi O Province O no. O 2515 O Innovative B-ORG Entrepreneurship I-ORG Training I-ORG Program I-ORG for I-ORG College I-ORG Students I-ORG of I-ORG Xianyang I-ORG Normal I-ORG College I-ORG no. O 2017065 B-AWARD and O University B-ORG students I-ORG innovation I-ORG and I-ORG entrepreneurship I-ORG base I-ORG team I-ORG project O no. O XSYC201710 B-AWARD This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 21606262 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG no. O 2017A030311003 B-AWARD Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG China I-ORG no. O 201707010473 B-AWARD and O Ordinary B-ORG University I-ORG Innovation I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG grant O no. O 2016KTSCX062 B-AWARD This O work O was O supported O in O part O by O Shanghai B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG Grant O No. O 2017SHZDZX01 B-AWARD the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0908105 O 2019YFA0905401 I-AWARD and I-AWARD 2016YFC1306900 O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U1804284 O 81421061 I-AWARD 81701321 I-AWARD 31571012 I-AWARD 91849104 I-AWARD 31770800 I-AWARD 81571329 I-AWARD 81501154 I-AWARD and I-AWARD 81871051 O Shanghai B-ORG Hospital I-ORG Development I-ORG Center I-ORG SHDC12016115 O Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Committee I-ORG 17JC1402900 O and I-AWARD 17490712200 O and O shanghai B-ORG municipal I-ORG health I-ORG commission I-ORG ZK2015B01 O and I-AWARD 201540114 O The O funding O bodies O did O not O participate O in O the O design O of O the O study O in O collection O analysis O and O interpretation O of O data O or O in O writing O the O manuscript O Financial O support O for O this O study O was O provided O by O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Xiamen I-ORG City I-ORG No. O 3502Z20151257 O Science B-ORG and I-ORG Technology I-ORG Key I-ORG Project I-ORG of I-ORG Fujian I-ORG Province I-ORG No. O 2015NZ0002-1 O and O Fujian B-ORG Institute I-ORG of I-ORG Subtropical I-ORG Botany I-ORG Foundation I-ORG No. O 20150318-1 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC0310903 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 41876161 B-AWARD and I-AWARD 21572210 O NSFC-Shandong O Joint O Fund O for O Marine O Science O Research O Centers O Grant O No. O U1606403 O and O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG of I-ORG Shandong I-ORG Province I-ORG Grant O No. O 2018CXGC1304 B-AWARD Financial O support O was O provided O by O Major B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG for I-ORG Water I-ORG Pollution I-ORG Control I-ORG and I-ORG Treatment I-ORG 2014ZX07305001 O National B-ORG major I-ORG scientific I-ORG instrument I-ORG equipment I-ORG development I-ORG project I-ORG 2017YFF0408500 O and O special B-ORG fund I-ORG of I-ORG State I-ORG Key I-ORG Joint I-ORG Laboratory I-ORG of I-ORG Environment I-ORG Simulation I-ORG and I-ORG Pollution I-ORG Control I-ORG 17Y01ESPCT O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O U1603232 B-AWARD the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2018YFD0502100 B-AWARD the O Autonomous B-ORG Region I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG No. O 2017B01005-2-1 B-AWARD and O the O Xinjiang B-ORG Agricultural I-ORG University I-ORG Graduate I-ORG Research I-ORG and I-ORG Innovation I-ORG Project I-ORG No. O XJAUGRI2017033 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O by O Army B-ORG Research I-ORG Office I-ORG http://www.arl.army.mil O W911NF-12–1–0390 B-AWARD the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG R01 O GM088344 O and O the O National B-ORG Science I-ORG Foundation I-ORG Cooperative O agreement O no. O DBI-0939454 B-AWARD BEACON O Center O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O financially O supported O by O the O innovation B-ORG project I-ORG of I-ORG Shanghai I-ORG University I-ORG of I-ORG TCM I-ORG no. O ZYX-CXYJ-018 B-AWARD Shanghai B-ORG Municipal I-ORG Education I-ORG Committee I-ORG no. O 2013JW17 B-AWARD and O Innovation B-ORG Project I-ORG for I-ORG Undergraduates I-ORG of I-ORG Shanghai I-ORG University I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG 2019SHUTCM183 O Neither O the O funding O source O nor O the O sponsor O had O any O role O in O the O design O of O this O study O or O its O execution O analyses O interpretation O of O the O data O or O decision O to O submit O results O The O work O of O ENS O IAI O DSK O IVS O AIG O LVS O and O VIT O was O supported O by O the O Russian B-ORG Science I-ORG Foundation I-ORG Grant O 16-14-00215 B-AWARD http://rscf.ru/en O The O work O of O IEK O was O supported O by O the O Russian B-ORG Foundation I-ORG for I-ORG Basic I-ORG Research I-ORG Grant O 18-04-01366 B-AWARD http://www.rfbr.ru/rffi/eng O The O work O of O SCRL O was O supported O by O a O Medical B-ORG Research I-ORG Council I-ORG Grant O MR B-AWARD L021676 I-AWARD https://mrc.ukri.org O GRM O RWB O LH, O AG O received O no O specific O funding O for O this O work O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG in I-ORG Shaanxi I-ORG Province I-ORG of I-ORG China O grant O number O 2023-YBGY-333 B-AWARD and O 2020ZDLGY14-05 B-AWARD the O Natural B-ORG Science I-ORG Basic I-ORG Research I-ORG Program I-ORG in I-ORG Shaanxi I-ORG Province I-ORG of I-ORG China O grant O number O 2022JQ-024 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG on I-ORG Applied I-ORG Physical I-ORG Chemistry I-ORG Laboratory I-ORG of I-ORG China O grant O number O WDYX22614260202 B-AWARD Supported O by O a O grant O 2022B0202060006 O from O Guangdong B-ORG Key I-ORG Areas I-ORG R&D I-ORG Program I-ORG Project O a O grant O CARS-01 O from O the O National B-ORG Rice I-ORG Industry I-ORG Technology I-ORG System I-ORG of I-ORG China O and O the O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG 2021A1515010410 O China O This O work O was O sponsored O by O Special B-ORG Research I-ORG Grant I-ORG for I-ORG Non-profit I-ORG Public I-ORG Service I-ORG Grant O No. O 201402004 B-AWARD Recipient O YWX O Guangdong B-ORG province I-ORG science I-ORG and I-ORG technology I-ORG plan I-ORG project I-ORG Grant O No. O 2016A02021800 B-AWARD Recipient O YWX O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Project I-ORG Grant O No. B-AWARD 81370765 O Recipient O CQZ O and O Science B-ORG and I-ORG Information I-ORG Technology I-ORG of I-ORG Guangzhou I-ORG Grant O No. O 201300000097 B-AWARD Recipient O CQZ O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC1105201 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81472043 O 81871743 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 2017ZDJC-12 O and O Shanghai B-ORG Nature I-ORG Science I-ORG Foundation(19ZR1464800 O This O work O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. I-AWARD 41576163 O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG for I-ORG Blue I-ORG Granary I-ORG 2018YFD0901500 O Shanghai B-ORG Sailing I-ORG Program I-ORG 17YF1407900 O the O Ocean B-ORG Public I-ORG Welfare I-ORG Scientific I-ORG Research I-ORG Project I-ORG China I-ORG 201205010 O and O the O Jiangsu B-ORG marine I-ORG science I-ORG and I-ORG technology I-ORG innovation I-ORG project I-ORG HY2017-4 O This O work O was O supported O by O the O Key B-ORG Laboratory I-ORG of I-ORG New I-ORG Technology I-ORG for I-ORG Construction I-ORG of I-ORG Cities I-ORG in I-ORG Mountain I-ORG Area I-ORG LNTCCMA-20230108 O the O Systematic B-ORG Project I-ORG of I-ORG Guangxi I-ORG Key I-ORG Laboratory I-ORG of I-ORG Disaster I-ORG Prevention I-ORG and I-ORG Engineering I-ORG Safety I-ORG 2021ZDK015 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 42207189 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 11672080 B-AWARD 31700815 O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFC0803802 B-AWARD the O Chongqing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O cstc2018jcyjAX0086 B-AWARD and O Shandong B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under I-ORG Grant I-ORG No. O ZR2018LA011 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31702187 O the O Key B-ORG Project I-ORG of I-ORG Shaanxi I-ORG Natural I-ORG Science I-ORG Basic I-ORG Research I-ORG Plan I-ORG 2022JZ-12 O the O Key B-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG Education I-ORG Department I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 22JY017 O and O the O Scientific B-ORG Research I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG University I-ORG of I-ORG Technology I-ORG SLGKYXM2202 O This O work O was O supported O in O data O analysis O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grants O No.31701238 O Key B-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG Hebei I-ORG Provience I-ORG China O No.182777105D O and O Key B-ORG Project I-ORG Plan I-ORG of I-ORG Medical I-ORG Science I-ORG Research I-ORG in I-ORG Hebei I-ORG Province I-ORG China I-ORG No.20180706 O This O work O was O funded O by O the O Education B-ORG Department I-ORG of I-ORG Henan I-ORG province I-ORG No. O 16A180030 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Henan I-ORG province I-ORG No. O 172102110103 B-AWARD the O National O fund O pre-research O projects O No. O 2018YZ10 B-AWARD 2018YZ14 B-AWARD and O the O Scientific O Research O Projects O for O High O Level O Talents O No. O 2014BZ02 B-AWARD 2014BZ03 B-AWARD and O 2014BZ07 B-AWARD of O Luoyang B-ORG Institute I-ORG of I-ORG Science I-ORG and I-ORG Technology O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 22064010 O and O 51862014 B-AWARD the O Key B-ORG R I-ORG I-ORG D I-ORG Program I-ORG of I-ORG Jiangxi I-ORG Province I-ORG 20192ACB60011 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Province I-ORG 20202ACBL213009 O and O 20212BAB203019 B-AWARD the O Thousand B-ORG Talent I-ORG Project I-ORG of I-ORG Jiangxi I-ORG Province I-ORG JXSQ2019201016 O and O the O Special B-ORG Research I-ORG on I-ORG Camphor I-ORG Tree I-ORG of I-ORG the I-ORG Jiangxi I-ORG Province I-ORG Department I-ORG of I-ORG Forestry I-ORG 2020CXZX07 O for O their O financial O support O of O this O work O ADDITION–Cambridge O was O supported O by O the O Wellcome B-ORG Trust I-ORG grant O reference O no. O G061895 B-AWARD the O Medical B-ORG Research I-ORG Council I-ORG MRC O grant O reference O no. O G0001164 O and O MRC O Epidemiology O Unit O programme O MC_UU_12015/4 B-AWARD the O NIHR O Health B-ORG Technology I-ORG Assessment I-ORG Programme I-ORG grant O reference O no. O 08/116/300 B-AWARD NIHR O Programme B-ORG Grants I-ORG for I-ORG Applied I-ORG Research I-ORG RP-PG-0606-1259 O NHS O Research O and O Development O R&D O support O funding O including O the O Primary O Care O Research O and O Diabetes O Research O Networks O and O the O NIHR O SJG O and O NJW O are O NIHR O senior O investigators O The O University O of O Cambridge O has O received O salary O support O in O respect O of O SJG O from O the O NHS O in O the O East O of O England O through O the O Clinical O Academic O Reserve O Bio-Rad O provided O equipment O for O HbA1ctesting O during O the O screening O phase O The O study O sponsors O were O not O involved O in O the O design O of O the O study O the O collection O analysis O and O interpretation O of O data O writing O the O report O or O the O decision O to O submit O the O report O for O publication O The O project O was O supported O by O a O grant O from O the B-ORG National I-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG 973 I-ORG Program I-ORG of I-ORG China I-ORG No. O 2015CB150300 O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFD0501200 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31602041 O the B-ORG Opening I-ORG Fund I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Veterinary I-ORG Etiological I-ORG Biology I-ORG No. O SKLVEB2016KFKT018 O and O the B-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG of I-ORG Jiaxing I-ORG No. O 2016AY23025 O This O research O was O funded O by O the O National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O Grant O Number O 21902157 O the O National O Natural O Science O Foundation O of O China O Grant O Number O 22172068 O Starting O Fund O for O Scientific O Research O of O High-Level O Talents O Anhui B-ORG Agricultural I-ORG University O Grant O Number O rc382108 O Key O Research I-ORG and I-ORG Development I-ORG Plan I-ORG of I-ORG Anhui I-ORG Province O Grant O Number O 2022e07020037 O and O Natural O Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province O Grant O Number O BK20221485 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O number O 81974350 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Grant O number O 2020CFA019 B-AWARD and O the O Research B-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG HUST O YCJJ202201023 B-AWARD This O research O was O funded O by O the O Chongqing B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG China O grant O number O CSTB2022NSCQ-BHX0687 B-AWARD Chongqing B-ORG Medical I-ORG Scientific I-ORG Research I-ORG Project I-ORG Joint I-ORG project I-ORG of I-ORG Chongqing I-ORG Health I-ORG Commission I-ORG and I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG China O grant O number O 2023MSXM006 B-AWARD and O the O Chongqing B-ORG Medical I-ORG and I-ORG Pharmaceutical I-ORG College I-ORG China O grant O number O YGZ2021133 B-AWARD This O work O was O supported O by O Medical O Research O Council O Doctoral O Training O Centre O scholarship O MR/K501281/1 O Imperial O College O scholarship O EP/M506345/1 O La O Caixa O studentship O to O A.R.M O FCT(BD/52036/2012 B-ORG to O A.L.N O British B-ORG Heart I-ORG Foundation I-ORG program O grant O RG/15/5/31446 O to O C.E O and O E.P O BHF B-ORG Chair O to O CE O CH/15/31199 O European B-ORG Commission I-ORG FGENTCARD O LSHG-CT-2006-037683 B-AWARD to O D.G O J.K.N O and O M.E.D O This O work O was O supported O in O part O by O Grant O 7172193 B-AWARD from O the O Beijing B-ORG Natural I-ORG Science I-ORG Foundation O Grant O 2017ZX09304026 B-AWARD from O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG for I-ORG Significant I-ORG New I-ORG Drugs I-ORG Creation O Grant O 81571384 B-AWARD from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O Grant O BJ-2018-137 B-AWARD from O the O Beijing B-ORG Hospital I-ORG Nova I-ORG Project I-ORG This O research O was O funded O by O the O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG 2020A1515110284 O the O Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG ZR2020QB158 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32161133013 O 32170038 B-AWARD and O 32201245 B-AWARD This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61403196 O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20140837 O the B-ORG Specialized I-ORG Research I-ORG Fund I-ORG for I-ORG the I-ORG Doctoral I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG of I-ORG China I-ORG 20133218120018 O and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG NS2014030 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2016YFA0602503 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 41701099 B-AWARD 41775116 B-AWARD 61871204 B-AWARD and B-AWARD 31470501 O and O Open B-ORG Fund I-ORG Project I-ORG of I-ORG Fujian I-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Information I-ORG Processing I-ORG and I-ORG Intelligent I-ORG Control I-ORG Grant O No. I-AWARD MJUKF-IPIC201812 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 31860176 B-AWARD the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shaanxi I-ORG grant O number O 2020ZDLSF06-06 B-AWARD the O Natural B-ORG Science I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG Shaanxi I-ORG grant O number O 2023-JC-QN-0245 B-AWARD the O Xi’an B-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG grant O number O 22FWQY14 B-AWARD and O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Gansu I-ORG grant O number O 20YF3FA037 B-AWARD The O authors O also O thank O Ecological O protection O and O high-quality O development O team O of O the O Qinling O Mountains O and O inland O river O basins O Key O Laboratory O for O ecological O restoration O and O high O quality O development O of O Qinling O Mountains O in O the O upper O and O middle O reaches O of O the O Yellow O River O Xi’an O Key O Laboratory O of O Plant O stress O physiology O and O ecological O restoration O technology O This O study O was O supported O by O the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 863 O Programme O No. O 2012AA10A402 B-AWARD 2012AA10A408 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31502156 B-AWARD 31502146 I-AWARD 31128017 O and O the O National B-ORG Flatfish I-ORG Industry I-ORG System I-ORG Construction I-ORG Programme I-ORG No. O nycytx-50-G03 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O EU B-ORG project O 2014-2020.4.01.15-0013 B-AWARD Swedish B-ORG Research I-ORG Council I-ORG VR-NT O 2017-03691 B-AWARD E.R.d.S O is O grateful O to O FAPESP B-ORG for O support O under O grant O 2022/03056-6 B-AWARD RNB O acknowledges O CNPq B-ORG for O a O fellowship O #402154/2022-3 O The O Brazilian O Nanotechnology O National O Laboratory O LNNano O is O acknowledged O for O granting O access O to O AFM B-ORG instruments I-ORG under O proposals O 20220321 B-AWARD and O 20230730 B-AWARD This O study O was O funded O by O the O earmarked B-ORG fund I-ORG for O CARS36 B-AWARD Heilongjiang B-ORG Province I-ORG Natural I-ORG Science I-ORG Foundation I-ORG for O Joint O Guide O Project O LH2022C030 O the O Young B-ORG Talents” I-ORG Project I-ORG of I-ORG Northeast I-ORG Agricultural I-ORG University I-ORG 2021 O and O the O Key B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Henan I-ORG No. O 222102110391 B-AWARD This O study O was O partially O supported O by O UCB B-ORG Pharma I-ORG grant O n. O RS235/12 B-AWARD AIRC B-ORG grant O n. O 14455 B-AWARD and O EPIGEN B-ORG grant O n. O 13/05/R/42 B-AWARD The O work O presented O in O this O paper O was O carried O out O thanks O to O the O support O of O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 61472166 B-AWARD the O Youth B-ORG Foundation I-ORG Project I-ORG of I-ORG Humanities I-ORG and I-ORG Social I-ORG Sciences I-ORG Research I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG in I-ORG China I-ORG grant O number O 17YJC870011 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG of I-ORG China I-ORG grant O number O BK20161199 B-AWARD the O Jiangsu B-ORG Overseas I-ORG Research I-ORG I-ORG Training I-ORG Program I-ORG for I-ORG University I-ORG Prominent I-ORG Young I-ORG I-ORG Middle-aged I-ORG Teachers I-ORG and I-ORG Presidents I-ORG grant O number O 201613 B-AWARD and O the O Planning B-ORG Foundation I-ORG Project I-ORG of I-ORG Humanities I-ORG and I-ORG Social I-ORG Sciences I-ORG Research I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG in I-ORG China I-ORG grant O number O 19YJA870005 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O We O acknowledge O the O financial O support O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81703360 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG Nos O ZR2016HB43 B-AWARD JQ201721 B-AWARD the B-ORG Young I-ORG Taishan I-ORG Scholars I-ORG Program I-ORG tsqn20161037 O and O the O Shandong O Talents O Team O Cultivation O Plan O of O University O Preponderant O Discipline O No. O 10027 B-AWARD This O work O was O funded O by O the O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG grant O number O 2019A1515110360 B-AWARD Guangdong B-ORG University I-ORG Teachers’ I-ORG Characteristic I-ORG Innovation I-ORG Research I-ORG Project I-ORG grant O number O 2021XJZZ12 B-AWARD Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG grant O number O 2022A1515010761 B-AWARD and O Foshan B-ORG Technology I-ORG Project I-ORG grant O number O 1920001000409 B-AWARD and O grant O number O CGZ0400191 B-AWARD The O present O study O was O supported O by O the O National B-ORG Cancer I-ORG Center I-ORG Research I-ORG and I-ORG Development I-ORG Fund I-ORG 23-A-16 O 23-A-17 I-AWARD 26-A-4 O and O Health O and O Labour O Sciences O Research O Expenses O for O Commission O Applied O Research B-ORG for I-ORG Innovative I-ORG Treatment I-ORG of I-ORG Cancer I-ORG from I-ORG the I-ORG Ministry I-ORG of I-ORG Health I-ORG Labour I-ORG and I-ORG Welfare I-ORG H26-applied-general-043,046 O Furthermore O this O research O was O supported O by O the O Practical O Research O for O Innovative O Cancer O Control O 15ck0106046h0002 O 15ck0106049h0002 O from O Japan B-ORG Agency I-ORG for I-ORG Medical I-ORG Research I-ORG and I-ORG Development O AMED O The O funding O source O had O no O role O in O the O design O data O collection O interpretation O of O data O or O writing O of O the O manuscript O for O the O present O clinical O study O This O research O was O funded O by O the O National B-ORG Aeronautics I-ORG and I-ORG Space I-ORG Administration I-ORG under O Grant O NNX16AT80A B-AWARD the O National B-ORG Science I-ORG Foundation I-ORG under O Grant O IIS-1528145 B-AWARD the O Air B-ORG Force I-ORG Office I-ORG of I-ORG Scientific I-ORG Research I-ORG with O Sponsor O Award O 3003832414 B-AWARD and O the O Airbus B-ORG Group O with O Sponsor O Award O 127302 B-AWARD Jennifer O Im O was O supported O by O an O Interdisciplinary B-AWARD Fellowship I-AWARD Program I-AWARD Award I-AWARD 2017–18 O from O the O Canadian B-ORG Frailty I-ORG Network O which O is O funded O by O the O Government O of O Canada’s O Networks O of O Centres O of O Excellence O Funding O was O provided O by O the O Health B-ORG System I-ORG Performance I-ORG Research I-ORG Network O Health O System O Performance O Research O Network O which O receives O funding O from O the O Ontario O Ministry O of O Health O and O Long-Term O Care O Health O Services O Research O Fund O #06034 B-AWARD and O the O Ontario O SPOR O Support O Unit O the O Temmy B-ORG Latner I-ORG Centre I-ORG for I-ORG Palliative I-ORG Care I-ORG through O the O Golda B-AWARD Fine I-AWARD Award O and O the O Trillium B-ORG Health I-ORG Partners I-ORG Foundation I-ORG through O a O fund O dedicated O to O the O senior O author O Dr. O Mathias I-AWARD Gysler I-AWARD Research I-AWARD Chair I-AWARD in I-AWARD Patient I-AWARD and I-AWARD Family I-AWARD Centered I-AWARD Care O The O findings O interpretations O and O conclusions O reported O in O this O study O solely O reflect O the O opinions O of O the O authors O and O are O independent O from O the O funders O This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0201305 O Huazhong B-ORG Agricultural I-ORG University I-ORG Scientific I-ORG I-ORG Technological I-ORG Self-Innovation I-ORG Foundation I-ORG 2016RC010 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31872143 O to O Zhulong O Chan O and O the B-ORG Youth I-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Hubei I-ORG Education I-ORG Department I-ORG Q20182702 O to O Wenli O Quan O Xun O Liu O acknowledges O the O support O from O the O China O Scholarship O Council O 2016–2020 O The O funding O bodies O had O no O roles O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O Japan B-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG KAKENHI O Grants O 26860059 B-AWARD 16H06215 B-AWARD and O 19H03381 B-AWARD to O Y.S O 16K08278 B-AWARD and O 19K07125 B-AWARD to O H.Y O and O 26293021 B-AWARD and O 18KK0218 B-AWARD to O Y.I O Experiments O in O Nagoya O Japan O were O also O supported O by O a O grant-in-aid O from O Takeda O Science O Foundation O Salt B-ORG Science I-ORG Research I-ORG Foundation I-ORG Grant1637 O and O Mitsui O Sumitomo O Insurance O Welfare O Foundation O to O Y.S O Studies O in O Calgary O Canada O were O funded O by O a O University B-ORG of I-ORG Calgary I-ORG research O grant O 100575 O This O study O was O supported O by O the B-ORG Strategic I-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Grant O No. O XDA16030400 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31621004 B-AWARD 31422038 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG Grant O No. O 2017YFA0103803 B-AWARD the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2014CB964800 B-AWARD CAS B-ORG Key I-ORG Projects I-ORG Grant O No. O QYZDY-SSW-SMC022 B-AWARD QYZDB-SSW-SMC002 B-AWARD This O work O was O supported O by O the O Key B-ORG R&D I-ORG Project I-ORG of I-ORG Hubei I-ORG Province I-ORG Social O Development O China O 2022BCA018 O to O K.H O the O Open O Project O Funding O of O the O Key B-ORG Laboratory I-ORG of I-ORG Fermentation I-ORG Engineering I-ORG Ministry O of O Education O 202209FE06 O to O Y.W O the O Initial B-ORG Project I-ORG for I-ORG High I-ORG Level I-ORG Talents I-ORG of I-ORG HBUT I-ORG 337193 O to O K.H O cooperative O Innovation B-ORG Center I-ORG of I-ORG Industrial I-ORG Fermentation I-ORG Ministry O of O Education O O Hubei O Province O China O 2022KF16 O to O K.H O This O research O was O supported O by O the O National B-ORG Key I-ORG Technology I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG grant O no. O 2021YFD2100605 B-AWARD Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG grant O no. O 4202014 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O nos O 62006008 B-AWARD and O 61873027 B-AWARD Humanity B-ORG and I-ORG Social I-ORG Science I-ORG Youth I-ORG Foundation I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG grant O no. O 20YJCZH229 B-AWARD Social B-ORG Science I-ORG Research I-ORG Common I-ORG Program I-ORG of I-ORG Beijing I-ORG Municipal I-ORG Commission I-ORG of I-ORG Education I-ORG grant O no. O SM202010011013 B-AWARD This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O nos O 51974339 B-AWARD and O 51674270 B-AWARD National B-ORG Major I-ORG Project I-ORG grant O no. O 2017ZX05009-003 B-AWARD Major B-ORG project I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 51490650 B-AWARD and O the O Foundation B-ORG for I-ORG Innovative I-ORG Research I-ORG Groups I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O nos O 51821092 B-AWARD and O 51521063 B-AWARD This O work O was O supported O by O Research O Projects O of O Gansu B-ORG Provincial I-ORG Hospital I-ORG Grant O no. I-AWARD 17GSSY9-1 I-AWARD and O 18GSSY7-3 O the O National B-ORG Social I-ORG Science I-ORG Fund I-ORG of I-ORG China I-ORG Grant O no. O 19ZDA142 B-AWARD and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O no. I-AWARD 18LZUJBWZX006 I-AWARD and I-AWARD Grant I-AWARD no.2019jbkyzy002 O Evidence-based O Social O Science O Research O This O research O is O supported O by O awards O from O the B-ORG National I-ORG Bio I-ORG and I-ORG Agro-Defense I-ORG Facility I-ORG Transition I-ORG Fund I-ORG the I-ORG USDA I-ORG National I-ORG Institute I-ORG of I-ORG Food I-ORG and I-ORG Agriculture I-ORG Hatch-Multistate I-ORG project O grant O number O 1021491 O USDA B-ORG ARS I-ORG Non-Assistance I-ORG Cooperative I-ORG Agreements O grant O numbers O 58-8064-8-011 O 58-8064-9-007 B-AWARD 58-3020-9-020 B-AWARD 59-0208-9-222 B-AWARD USDA B-ORG NIFA I-ORG Award I-ORG 2022-67015-36516 B-AWARD and O USDA B-ORG NIFA I-ORG Subaward I-ORG 25-6226-0633-002 B-AWARD National B-ORG Pork I-ORG Board I-ORG Grant O grant O number O 18-059 O Department B-ORG of I-ORG Homeland I-ORG Security O grant O number O 70RSAT19CB0000027 O This O work O was O supported O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21575103 O 61376082 B-AWARD 31671421 B-AWARD and O 81472683 B-AWARD 863 B-ORG program I-ORG 2015AA020403 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2016YFC0900100 O This O research O was O funded O by O the O Open B-ORG Foundation I-ORG of I-ORG Hubei I-ORG Key I-ORG Laboratory I-ORG of I-ORG Pollutant I-ORG Analysis I-ORG I-ORG Reuse I-ORG Technology I-ORG Hubei O Normal O University O PA220103 O graduate B-ORG innovative I-ORG research I-ORG project I-ORG construction I-ORG of I-ORG Hubei I-ORG Normal I-ORG University I-ORG No. O 20220454 B-AWARD and O the B-ORG College I-ORG Students’ I-ORG Innovative I-ORG Entrepreneurial I-ORG Training I-ORG Plan I-ORG Program I-ORG No. O 202210513014 B-AWARD No. O D202210513073 B-AWARD This O work O was O supported O by O the O Dirección B-ORG General I-ORG de I-ORG Investigación I-ORG Científica I-ORG y I-ORG Técnica I-ORG Spanish O Government O projects O CGL2013–49097-C2 B-AWARD CGL2016–75694-P B-AWARD and O CGL2017–84297-R B-AWARD and O the O Generalitat B-ORG de I-ORG Catalunya I-ORG “Ajuts O a O grups O de O recerca O consolidats” O 2017SGR01116 B-AWARD S.G O benefitted O from O a O Ramón B-ORG y I-ORG Cajal O contract O RYC-2014-16608 O from O the O government O of O Spain O This O study O was O supported O by O the O Academic B-ORG Leader I-ORG Program I-ORG of I-ORG Wuhan I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG Grant O No. O 201150530155 B-AWARD the O Clinical B-ORG Medical I-ORG Research I-ORG Program I-ORG of I-ORG Wuhan I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG Grant O No. O WX15A02 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG Grant O No. O CFC1045 B-AWARD as O well O as O the O Science B-ORG Technology I-ORG and I-ORG Innovation I-ORG Commission I-ORG of I-ORG Shenzhen I-ORG Municipality I-ORG Grant O No. O JCYJ20140419122040615 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 81371983 B-AWARD the O Social B-ORG Development I-ORG of I-ORG Technology I-ORG Research I-ORG Projects I-ORG of I-ORG Gansu I-ORG Province I-ORG grant O no. O S04671 B-AWARD and O the O Youth B-ORG Science I-ORG and I-ORG Technology I-ORG Foundation I-ORG of I-ORG Gansu I-ORG Province I-ORG grant O no. O 1606RJYA300 B-AWARD This O study O was O supported O by O The B-ORG PhD I-ORG Start-up I-ORG Fund I-ORG of I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province I-ORG China I-ORG 201501010 O Foundation B-ORG of I-ORG Liaoning I-ORG Educational I-ORG Committee I-ORG L2015597 O and O The B-ORG Scientific I-ORG Start-up I-ORG Fund I-ORG for I-ORG Youth I-ORG of I-ORG School I-ORG of I-ORG Stomatology I-ORG K10159-15-01 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O sponsored O and O conducted O in O sites O corresponding O to O Centro O Latino O Americano O de O Investigación O en O Malaria O CLAIM O sponsored O by O NIAID/ICEMR B-ORG U19AI089702 O Colciencias B-ORG 360-2011 O 458-2012 B-AWARD 719-2013 B-AWARD and O Colombian B-ORG Presidential I-ORG Agency I-ORG of I-ORG International I-ORG Cooperation I-ORG 045-2013 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O A.G O acknowledges O support O from O the O EPSRC B-ORG under O grant O no. O EP/K024116/1 B-AWARD R.A.J O and O D.A.W O acknowledge O support O from O the O French-Argentinian B-ORG collaborative I-ORG project O PICS B-AWARD 06687 O H.M.P O acknowledges O support O from O SECyT-UNC B-ORG CONICET I-ORG and I-ORG ANPCyT B-ORG D.A.W O acknowledges O support O from O UBACyT O grant O no. O 20020130100406BA B-AWARD and O ANPCyT O grant O no. O PICT-2010 B-AWARD 02483 O This O study O was O supported O by O the B-ORG Guangdong I-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG 2023A1515012192 O 2023A1515030108 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81600751 O 81700820 B-AWARD and O the B-ORG Pearl I-ORG River I-ORG Nova I-ORG Program I-ORG of I-ORG Guangzhou I-ORG 201806010167 O This O research O was O funded O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O number O 2016YFD0400601 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 31671859 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG grant O number O k3080215804 B-AWARD and O the O Beijing B-ORG Advanced I-ORG Innovation I-ORG Center I-ORG for I-ORG Food I-ORG Nutrition I-ORG and I-ORG Human I-ORG Health O Beijing O Technology O and O Business O University O grant O number O 20181034 B-AWARD This O work O was O funded O by O 1) O The B-ORG Earmarked I-ORG Fund I-ORG for I-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-45),http://www.moa.gov.cn/zwllm/tzgg/tz/201703/t20170320_5530342.htm O Jiashou O Liu O 2) O The B-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG Supporting I-ORG Program I-ORG of I-ORG China I-ORG 2012BAD25B08),http://program.most.gov.cn O Jiashou O Liu O 3) O The B-ORG China I-ORG Three I-ORG Gorges I-ORG Corporation I-ORG Project I-ORG CT-12-08-01),http://www.ctg.com.cn/sxjt/kjcx/_301965/index.html O Zhongjie O Li O and O Jiashou O Liu O 4) O The B-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Freshwater I-ORG Ecology I-ORG and I-ORG Biotechnology I-ORG 2014FBZ04),http://febl.ihb.cas.cn O Jiashou O Liu O and O Zhongjie O Li; O 5) O USDA O National O Institute O of O Food O and O Agriculture O Hatch O Project O 230537 O Brian O R. O Murphy O and O 6) O The O Acorn O Alcinda O Foundation O Lewes O Delaware O USA O Brian O R O Murphy O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 52277134 O 51907007 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Beijing I-ORG Municipality I-ORG 3212034 O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Laser I-ORG Interaction I-ORG with I-ORG Matter I-ORG SKLLIM2112 O and O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Intense I-ORG Pulsed I-ORG Radiation I-ORG Simulation I-ORG and I-ORG Effect I-ORG SKLIPR1906 O This O work O was O supported O by O the B-ORG Young I-ORG Core I-ORG Plan I-ORG of I-ORG the I-ORG Beijing I-ORG Academy I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG BJAST O No. O 201528 B-AWARD the O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 8142017 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 41475133 B-AWARD This O work O is O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81670806 B-AWARD 81972133 B-AWARD 81300716 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O xzy012019094 B-AWARD Natural B-ORG Science I-ORG Basic I-ORG Research I-ORG Project I-ORG of I-ORG Shaanxi I-ORG Province I-ORG No. O 2017JM8015 B-AWARD This O research O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O No.51878567 O and O the O China B-ORG Railway I-ORG Corporation I-ORG Science I-ORG And I-ORG Technology I-ORG Research I-ORG And I-ORG Development I-ORG Program O grant O No. O P2018G007 B-AWARD and O No. O P2018G048 B-AWARD and O Chengdu B-ORG Science I-ORG and I-ORG Technology I-ORG Project O grant O No. O 2022-XT00-00002-GX B-AWARD This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81602907 B-AWARD and O 81702606 B-AWARD the O funds O from O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Jilin I-ORG Province I-ORG 20170520007JH O and O the O funds O from O Commission B-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG of I-ORG Jilin I-ORG Province I-ORG 2017Q037 O The O National O Natural O Science O Foundation O of O China O plays O role O in O study O design O and O in O writing O the O manuscript O the O others O play O role O in O collection O analysis O and O interpretation O of O data O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81870550 B-AWARD Innovation B-ORG Seed I-ORG Fund I-ORG Development I-ORG Project I-ORG of I-ORG Wuhan I-ORG University I-ORG School I-ORG of I-ORG Medicine I-ORG Grant O No. O TFZZ2018009 B-AWARD and O Medical B-ORG Science I-ORG Advancement I-ORG Program I-ORG Basic I-ORG Medical I-ORG Sciences I-ORG of I-ORG Wuhan I-ORG University I-ORG Grant O No. O TFJC2018001 B-AWARD This O study O was O funded O by O the O Open B-ORG Project I-ORG Program I-ORG of I-ORG China-Canada I-ORG Joint I-ORG Lab I-ORG of I-ORG Food I-ORG Nutrition I-ORG and I-ORG Health O Beijing O Technology O and O Business O University O BTBU O KFKT-ZJ-201801 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81903316 O Major B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Medicine I-ORG and I-ORG Health I-ORG of I-ORG Zhejiang I-ORG Province I-ORG grant O WKJ-ZJ-1911 B-AWARD and O Social B-ORG Development I-ORG Scientific I-ORG Research I-ORG Projects I-ORG of I-ORG the I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG of I-ORG Hangzhou I-ORG grant O 20180417A02 B-AWARD I-AWARD 20180533B84 O JF O was O supported O by O the O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health I-ORG of O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG under O Award O Number O T32MH073526 B-AWARD The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O National O Institutes O of O Health O This O work O was O also O funded O by O grant O 20144605 B-AWARD from O the O Dup15q B-ORG Alliance I-ORG SSJ O received O funding O http://www.dup15q.org O R01 B-AWARD GM111378-01A1 I-AWARD from O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG DS O received O funding O https://www.nigms.nih.gov O National O Institute O of O Mental O Health O K23MH094517-01 B-AWARD SSJ O received O funding O https://www.nimh.nih.gov O and O National B-ORG Institute I-ORG of I-ORG Child I-ORG Health I-ORG and I-ORG Human I-ORG Development I-ORG U54HD087101 B-AWARD SSJ O and O PG O received O funding O https://www.nichd.nih.gov O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Shinan B-ORG District I-ORG Science I-ORG and I-ORG Technology I-ORG Foundation I-ORG Qingdao O 2022-2-027-ZH O Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG YSFRI I-ORG CAFS I-ORG 20603022022005 O Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG CAFS I-ORG NO.2020TD39 O This O study O was O financially O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2018YFD1000200 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31772275 O and O the B-ORG Natural I-ORG Science I-ORG Fund I-ORG for I-ORG Excellent I-ORG Young I-ORG Scholars I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2018JL014 O The O funders O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the B-ORG project-sponsored I-ORG by I-ORG SRF I-ORG for I-ORG ROCS I-ORG SEM I-ORG K513901814 O the B-ORG Soochow I-ORG University I-ORG high-level I-ORG scientific I-ORG research I-ORG foundation I-ORG for I-ORG the I-ORG introduction I-ORG talent I-ORG Q413900612 O Pre-research B-ORG foundation I-ORG for I-ORG nature I-ORG science I-ORG of I-ORG Soochow I-ORG University I-ORG Q313904713 O and O Key B-ORG technologies I-ORG of I-ORG prevention I-ORG and I-ORG control I-ORG of I-ORG diseases I-ORG and I-ORG infectious I-ORG diseases I-ORG in I-ORG Suzhou I-ORG City(Gwzx201506、Gwzx201605、 O Gwzx201706 B-AWARD This O study O was O partially O supported O by O grants O from O the O Xunta B-ORG de I-ORG Galicia I-ORG AC: O IN606A-2021/015 B-AWARD TS: O IN607D B-AWARD 2020/09 O and O IN607A2022/07 B-AWARD DRS O IN606B-2021/010 B-AWARD the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Innovation I-ORG TS: O RTI2018-102165-B-I00 B-AWARD TS: O RTC2019-007373-1 B-AWARD and O TS: O PDC2022-134000-I00 B-AWARD and O the O Institute B-ORG of I-ORG Health I-ORG Carlos I-ORG III I-ORG TS: O PI22/00938 B-AWARD and O CB22/05/00067 B-AWARD This O research O was O supported O by O CIBER B-ORG Consorcio I-ORG Centro I-ORG de I-ORG Investigación I-ORG Biomédica I-ORG en I-ORG Red I-ORG Enfermedades I-ORG Neurodegnerativas I-ORG CIBERNED O CB22_05_00067 O Instituto O de O Salud O Carlos O III O Ministerio O de O Ciencia O e O Innovación O and O Unión O Europea O – O European O Regional O Development O Fund O Furthermore O this O study O was O also O supported O by O grants O from O the O INTERREG B-ORG Atlantic I-ORG Area I-ORG TS: O EAPA_791/2018 B-AWARD NEUROATLANTIC I-AWARD project O INTER-REG B-ORG V I-ORG A I-ORG España I-ORG Portugal I-ORG POCTEP O TS: O 0624_2IQBIONEURO_6_E B-AWARD European B-ORG Commission I-ORG under I-ORG the I-ORG PANA I-ORG project I-ORG Call O H2020-NMP-2015 B-AWARD two-stage O grant O 686009 B-AWARD and O the O European O Regional O Development O Fund O ERDF O Moreover O TS O CPII17/00027 O was O recipient O of O a O research O contract O from O the O Miguel B-ORG Servet I-ORG Program I-ORG from I-ORG ISCIII O Finally O D.R.-S O CD21/00166 O is O recipient O of O a O postdoctoral O research O contract O from O the O Sara B-ORG Borrel I-ORG Program I-ORG from I-ORG ISCIII O The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Precision O Medicine O Research O Program O of O the O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG KJZD-EW-L14 O Strategic O Priority O Research O Program O of O the O Chinese O Academy O of O Sciences O XDA01040407 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31471395 O 91019024 B-AWARD 31540033 B-AWARD and O 31100558 B-AWARD National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 O Program O 2012CB518302 B-AWARD and O 2013CB911001 B-AWARD and O 100 O Talents O Project O The O work O was O funded O by O the O National B-ORG Planning I-ORG Office I-ORG of I-ORG Philosophy I-ORG and I-ORG Social I-ORG Science I-ORG of O China O No. O 16FJY008 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 11801060 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG No. O ZR2016FM26 B-AWARD This O work O was O supported O by O the O Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Committee I-ORG Basic O Science O Research O Grant O JCYJ20170818154941048 B-AWARD to O ZHOU O Haokui O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0907505 O and I-AWARD 2018YFA0900704 O Key B-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG KFZD-SW-219-5 O and O International B-ORG Partnership I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG 153D31KYSB20170121 O This O work O was O also O funded O by O the O Shenzhen B-ORG Peacock I-ORG Team I-ORG Plan I-ORG KQTD2015033117210153 O and I-AWARD KQTD2016112915000294 O Financial O support O was O also O provided O by O the O Bio-Med O Big O Data O Center O of O PICB O of O SINH O and O Shandong B-ORG Academician I-ORG Workstation I-ORG Program I-ORG 170401 B-AWARD to O ZHAO O Guo-Ping O Shandong O Children’s O Microbiome O Center O Qilu O Children’s O Hospital O of O Shandong O University O This O work O was O financially O supported O by O the O National B-ORG Key I-ORG Research I-ORG Project I-ORG Grant O no. O 2016YFD0101601 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O no. O 31371699 B-AWARD National B-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Plan I-ORG Grant O no. O 2013BAD04B01 B-AWARD and O 2014BAD01B09 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Beijing I-ORG Grant O no. O 5131001 B-AWARD Special B-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Ability I-ORG Construction I-ORG of I-ORG BAAFS I-ORG Grant O no. O KJCX20140405 B-AWARD and O Shanxi B-ORG Province I-ORG Science I-ORG Foundation I-ORG for I-ORG Youths I-ORG Grant O no. O 2015021145 B-AWARD National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH O AG059217 B-AWARD O AG061875 B-AWARD for O TYH O NIH O AG062257 B-AWARD AG057509 B-AWARD AG054111 B-AWARD and O AG020670 B-AWARD for O HZ; O NIH O AG057981 B-AWARD BrightFocus B-ORG Foundation I-ORG A2016346F B-AWARD Alzheimer B-ORG Association I-ORG AARG-17-500335 B-AWARD O Florida B-ORG Department I-ORG of I-ORG Health I-ORG 8AZ07 B-AWARD for O CL. O This O investigation O is O financially O supported O by O Science B-ORG Center I-ORG for I-ORG Gas I-ORG Turbine I-ORG Project I-ORG P2022-C-IV-002-001 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Chain I-ORG under O grant O No.51601158 O Key-Area B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2020B0101330001 O and O the O Project B-ORG Funding I-ORG to I-ORG the I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG the I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Sichuan I-ORG Province I-ORG Grant O No. O 2021ZYCD003 B-AWARD and O 2021ZYD0099 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81772428 O the O Special B-ORG Program I-ORG of I-ORG Guangdong I-ORG Frontier I-ORG and I-ORG Key I-ORG Technological I-ORG Innovation I-ORG 2015B010125006 O the O High-level B-ORG University I-ORG Construction I-ORG Funding I-ORG of I-ORG Guangdong I-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG LC2016ZD032 O Australia O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG Grant O 1158402 O Ningbo B-ORG Science I-ORG Technology I-ORG and I-ORG People-Benefit I-ORG Program I-ORG 2017C50048 O and O Ningbo B-ORG Medical I-ORG Science I-ORG Technology I-ORG Program I-ORG 2016A22 O D.L.H.B O is O a O Welcome B-ORG senior I-ORG clinical I-ORG scientist I-ORG ref O no. O 095698z/11/z B-AWARD and O 202747/z/16/z B-AWARD M.C O received O a O Fondecyt B-ORG Regular I-ORG 2016/1161019 O and O an O Early O Career O Research O grant O from O IASP B-ORG 20 O to O perform O this O work O I.F O received O a O Fondecyt O de O Iniciación O grant O number O 2014/11140440 B-AWARD that O contributed O to O this O work O This O research O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0201300 O the O Guangdong O Provincial O Special O Fund O for O Modern B-ORG Agriculture I-ORG Industry I-ORG Technology I-ORG Innovation I-ORG Teams I-ORG Department I-ORG of I-ORG Agriculture I-ORG and I-ORG Rural I-ORG Affairs I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2019KJ125 B-AWARD the O Innovation B-ORG Team I-ORG of I-ORG Modern I-ORG Agricultural I-ORG Industry I-ORG Generic I-ORG Key I-ORG Technology I-ORG R&D I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2019KJ134 O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC1200600 O and O the O Open O Fund O of O the O Guangxi B-ORG Key I-ORG Laboratory I-ORG of I-ORG Biology I-ORG for I-ORG Crop I-ORG Diseases I-ORG and I-ORG Insect I-ORG Pests I-ORG China I-ORG 2016-KF-3 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Beijing B-ORG Municipal I-ORG Science I-ORG I-ORG Technology I-ORG Commission I-ORG No: O Z171100001017197 B-AWARD the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No: O 2016YFC0103003 B-AWARD the B-ORG National I-ORG Basic I-ORG Research I-ORG Program I-ORG program I-ORG 973 I-ORG of I-ORG China I-ORG 2013CB733805 O and O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81070925 O 81471767 B-AWARD The O funding O body O had O no O role O or O interference O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O in O part O by O the O Shanghai B-ORG Municipality I-ORG Health I-ORG Bureau I-ORG Youth I-ORG Project I-ORG 2013-121 O the O Shanghai B-ORG Municipality I-ORG Jinshan I-ORG District I-ORG Health I-ORG Bureau I-ORG Youth I-ORG Project I-ORG JSKJ-KTQN-2013-02 O and O Shanghai B-ORG Municipality I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG Project I-ORG 13ZR1405800 O This O work O was O supported O by O open O project O of O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Fiber I-ORG Material I-ORG Modification I-ORG KF2203 O hydrogen O energy O special O project O Science B-ORG and I-ORG Technology I-ORG Committee I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG No. O 19511106703 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 2232020G-12 B-AWARD C.W O acknowledges O the O support O from O the O National O Key O R&D O Program O on O Nano O Science O O Technology O of O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of O China O 2017YFA0207301 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21925110 O 21890751 B-AWARD and O 91745113 B-AWARD the O National O Program O for O Support O of O Top-notch O Young O Professionals O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG WK2060190084 O the O Major O Program O of O Development B-ORG Foundation I-ORG of I-ORG Hefei I-ORG Center I-ORG for I-ORG Physical I-ORG Science I-ORG and I-ORG Technology I-ORG 2016FXZY001 O and O the O Users O with O Excellence O Project O of O Hefei B-ORG Science I-ORG Center I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG 2021HSC-UF004 O Y.X O acknowledges O the O support O from O the O Strategic O Priority O Research O Program O of O Chinese O Academy O of O Sciences O XDB36000000 O J.P O acknowledges O the O support O from O the O National O Natural O Science O Foundation O of O China O 22005284 O Y.G O acknowledges O the O support O from O the O National O Natural O Science O Foundation O of O China O U2032161 O W.B O acknowledges O the O support O from O the O National O Natural O Science O Foundation O of O China O U1832168 O and O the O Anhui B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG 1808085MB26 O This O work O was O supported O by O Stiftelserna B-ORG Wilhelm I-ORG och I-ORG Martina I-ORG Lundgrens I-ORG 2015-0349 O Stiftelsen B-ORG Handlanden I-ORG Hjalmar I-ORG Svenssons I-ORG HJSV2014045 O Gun B-ORG och I-ORG Bertil I-ORG Stohnes I-ORG 20140106 O Fredrik B-ORG och I-ORG Ingrid I-ORG Thurings I-ORG Stiftelse I-ORG 20131211 O Sigurd B-ORG och I-ORG Elsa I-ORG Goljes I-ORG Minne I-ORG LA20l3-0235 O and O Swedish B-ORG Society I-ORG of I-ORG Medicine I-ORG SLS-348481 O and O Göteborgs B-ORG Läkaresällskap I-ORG 183/13 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O The O British B-ORG Academy I-ORG Grant O number O PF110041 B-AWARD to O V.S O and O the O Medical B-ORG Research I-ORG Council I-ORG Grant O numbers O MC_PC_13027 B-AWARD MC_UU_12017/12 B-AWARD MC_UU_12017/14 B-AWARD to O S.C O and O the O Chief B-ORG Scientist I-ORG Office I-ORG of I-ORG the I-ORG Scottish I-ORG Government I-ORG Health I-ORG Directorates I-ORG Grant O numbers O SPHSU12 B-AWARD and O SPHSU14 B-AWARD to O S.C O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O Grant O number O 51805143 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG Grant O number O E2019202131 B-AWARD and O Project B-ORG Support I-ORG for I-ORG the I-ORG Introduced I-ORG Overseas I-ORG Students I-ORG of I-ORG Hebei I-ORG Province I-ORG Grant O number O C20190324 B-AWARD This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 11204163 B-AWARD and O no. O 61704098 B-AWARD Doctoral B-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG no. O BS2013SF018 B-AWARD and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shangdong I-ORG Province I-ORG no. O ZR2017BF025 B-AWARD This O study O was O sponsored O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81701180 O 81701229 B-AWARD and O 81701230 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20160605 O BK20160607 B-AWARD and O the O Shanghai B-ORG Sailing I-ORG Program I-ORG 19YF1430100 O There O was O no O relationship O with O any O industry O The O study O was O financially O supported O by O grants O from O the B-ORG Medical I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG grant O number O A2013432 B-AWARD the B-ORG Science I-ORG and I-ORG Technology I-ORG planning I-ORG project I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG grant O number O 2012B031800489 B-AWARD the B-ORG Postgraduate I-ORG Cultivation I-ORG of I-ORG Guangdong I-ORG Medical I-ORG University I-ORG China I-ORG grant O number O YC1201 B-AWARD This O work O was O supported O by O a O grant O from O the O Department B-ORG of I-ORG Health I-ORG Policy I-ORG Research I-ORG Program I-ORG Policy O Research O Unit O in O Behaviour O and O Health O PR-UN-0409-10109 O the O Medical B-ORG Research I-ORG Council I-ORG Unit O Programme O number O MC_UU_12015/3 B-AWARD and O the O British B-ORG Heart I-ORG Foundation I-ORG Intermediate O Basic O Science O Research O Fellowship O grant O FS/12/58/29709 B-AWARD to O KW O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFA0106700 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 91753137 O 31471252 B-AWARD 31771462 B-AWARD 81772614 B-AWARD U1611261 B-AWARD 31801105 B-AWARD 81802438 B-AWARD Program O for O Guangdong B-ORG Introducing I-ORG Innovative I-ORG and I-ORG Entrepreneurial I-ORG Teams I-ORG 2017ZT07S096 O Guangdong B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2018A030313323 O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou O China O 201604020003 O and O 201604046001 B-AWARD Fundamental O Research O Funds O for O the O Central O Universities O SYSU O 19ykpy184 O Funding O for O open O access O charge O National O Key O R&D O Program O of O China O 2017YFA0106700 O National O Natural O Science O Foundation O of O China O 91753137 O 31471252 O 31771462 O 81772614 O U1611261 O 31801105 O 81802438 O Program O for O Guangdong O Introducing O Innovative O and O Entrepreneurial O Teams O 2017ZT07S096 O Guangdong O Natural O Science O Foundation O 2018A030313323 O Science O and O Technology O Program O of O Guangzhou O China O 201604020003 O and O 201604046001 O Fundamental O Research O Funds O for O the O Central O Universities O SYSU O 19ykpy184 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61731008 O 61871428 B-AWARD U1809205 O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG of O China O LJ19H180001 O and O by O the O King B-ORG Abdullah I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG KAUST O Office O of O Sponsored O Research O OSR O under O award O no. O URF/1/3450-01 B-AWARD This O work O was O partially O supported O by O EP/J019305/1 B-AWARD for O E.I.P B-ORG EP/J019321/1 B-AWARD for O P.M B-ORG EP/J019569/1 B-AWARD for O J.-M.V.-B B-ORG and I-ORG O.T O This O work O was O also O supported O by: O EPSRC B-ORG grant O nos O EP/K032208/1 B-AWARD Parts O of O the O research O presented O in O this O paper O were O carried O out O on O the O High O Performance O Computing O Cluster O supported O by O the O Research O and O Specialist O Computing O Support O service O at O the O University O of O East O Anglia O This O research O was O funded O by O São B-ORG Paulo I-ORG Research I-ORG Foundation I-ORG FAPESP O grants O 2011/13630-7 B-AWARD 2016/25201-7 B-AWARD Coordination B-ORG for I-ORG the I-ORG Improvement I-ORG of I-ORG Higher I-ORG Education I-ORG Personnel I-ORG CAPES O finance O code O 001 B-AWARD and O National B-ORG Council I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Development I-ORG grants O 306345/2016-1 B-AWARD and O 301924/2019-8 B-AWARD We O gratefully O acknowledge O financial O support O from O the O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG 18ZR1434200 O the O Social B-ORG Development I-ORG Project I-ORG of I-ORG Yangzhou I-ORG Key I-ORG Research I-ORG Program I-ORG YZ2015070 O Shanghai B-ORG Municipal I-ORG Education I-ORG Commission—Gaofeng I-ORG Clinical I-ORG Medicine I-ORG Grant O Support O 20171906 O the O Excellent B-ORG Youth I-ORG Scholars I-ORG of I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG School I-ORG of I-ORG Medicine I-ORG 17XJ11004 O and O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Molecular I-ORG Engineering I-ORG of I-ORG Polymers I-ORG Fudan O University O K2018-02 B-AWARD This O work O was O supported O by O grants O from O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Taiwan I-ORG MOST O 104-3113-B-076–001 I-AWARD MOST I-AWARD 104–2321-B-010-017 I-AWARD MOST105-2321-B-010-008 I-AWARD MOST105-2325-B-010-007 I-AWARD MOST I-AWARD 106-2321-B-010–005 I-AWARD MOST I-AWARD 106-3011-B-010-001 I-AWARD MOST I-AWARD 106-2320-B-010-018 O and O the O Ministry B-ORG of I-ORG Education I-ORG Aiming I-ORG for I-ORG the I-ORG Top I-ORG University I-ORG Plan I-ORG 106AC-P645 O 106AC-P632 I-AWARD 105AC-P645 I-AWARD 104AC-P693 O and O Cheng B-ORG Hsin I-ORG General I-ORG Hospital I-ORG Foundation I-ORG CY10625 O CY10727 O and O Yen B-ORG Tjing I-ORG Ling I-ORG Medical I-ORG Foundation I-ORG CI-107-9 O This O work O was O supported O by O the O Croatian B-ORG Science I-ORG Foundation O grant O number O 7235 B-AWARD http://www.hrzz.hr/default.aspx?ID=47 O European O Community’s O Seventh B-ORG Framework I-ORG Programme I-ORG FP7/2007–2013 O https://ec.europa.eu/research/fp7/index_en.cfm O BioStruct-X O grant O number O 283570 B-AWARD the O Croatian B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Education I-ORG funding O Bilateral O project O with O Austria O number O 533-19 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. B-AWARD 31872296 I-AWARD and I-AWARD No. I-AWARD 31972618 O the O Chongqing B-ORG Research I-ORG Program I-ORG of I-ORG Basic I-ORG Research I-ORG and I-ORG Frontier I-ORG Technology I-ORG Grant O No. B-AWARD CSTC2017JCYJAX0090 I-AWARD and I-AWARD No. I-AWARD CSTC2018JCYJAX0396 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of O China O Grant O No. B-AWARD XDJK2018AB001 O We O would O like O to O thank O Editage O for O polishing O the O English O in O the O manuscript O This O work O was O supported O in O part O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG 2019YFD0902005 O the O Key-Area B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2020B1111030004 O the O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Zhanjiang I-ORG City I-ORG 2019A01015 O 2019A01033 B-AWARD and O the O Innovative B-ORG Team I-ORG Program I-ORG of I-ORG High I-ORG Education I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2021KCXTD021 O The O work O was O supported O by O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2019M650057 B-AWARD the O National B-ORG Science I-ORG Foundation I-ORG for I-ORG Young I-ORG Scientists I-ORG of I-ORG China I-ORG Grant O No.81600777 O and O the O Basic B-ORG Research I-ORG Fund I-ORG for I-ORG Young I-ORG Instructors I-ORG of I-ORG Higher I-ORG Education I-ORG in I-ORG Liaoning I-ORG Province I-ORG Grant O No. O LQNK201717 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31560547 B-AWARD the O Talents B-ORG of I-ORG Guizhou I-ORG Science I-ORG and I-ORG Technology I-ORG Cooperation I-ORG Platform I-ORG [2017]5603 O the O Scientific B-ORG and I-ORG Technological I-ORG Innovation I-ORG Platform I-ORG of I-ORG Guizhou I-ORG Province I-ORG No. O 2014-4003 B-AWARD and O the O Research B-ORG institutions I-ORG Enterprise I-ORG Action I-ORG Program I-ORG of I-ORG Guizhou I-ORG Province I-ORG No. O 2014-4007 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31960116 O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2018YFD0201504 O the O Educational O Commission O of O Jiangxi O Province O of O China O GJJ180747 O and O Science B-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Jiangxi I-ORG Province I-ORG 20171BCB23074 O the O earmarked O fund O for O Jiangxi O Agriculture O Research O System O JXARS-07 O and O Key B-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG of I-ORG Jiangxi I-ORG Province I-ORG 20192BBF60057 O This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFA0701200 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Tianjin I-ORG No. O 17JCZDJC38600 B-AWARD the O Postdoctoral B-ORG Innovative I-ORG Talent I-ORG Support I-ORG Program I-ORG of I-ORG China I-ORG BX20190230 O This O work O was O partially O supported O by O a O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O grant O grant O no O 81471781 B-AWARD and O a O National B-ORG major I-ORG scientific I-ORG instruments I-ORG and I-ORG equipment I-ORG development I-ORG projects I-ORG grant O grant O no O 2012YQ160203 B-AWARD to O Dr. O Shengrong O Sun O This O work O was O also O supported O by O a O NSFC O grant O grant O no O 81502665 B-AWARD to O Yimin O Zhang O and O a O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG China I-ORG grant O to O Shan O Zhu O grant O no O 2042014kf0189 B-AWARD This O research O was O funded O by O the O grant O projects O of O the O Czech B-ORG Ministry I-ORG of I-ORG Health I-ORG NU22-03-00276 B-AWARD and O DRO-VFN-64165 B-AWARD Charles B-ORG University I-ORG projects O Cooperatio O research O area O DIAG O and O SVV260516 B-AWARD Ministry O of O Education O Youths O and O Sports O of O the O Czech O Republic O programme O EXCELES O no. O LX22NPO05102 B-AWARD funded O by O the O European B-ORG Union–Next I-ORG Generation I-ORG EU O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51705104 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG HIT O NSRIF I-AWARD 2018 I-AWARD 35 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017M610206 O and I-AWARD 2018T110289 O and O Heilongjiang O Postdoctoral O Fund(LBH-Z16079 O and O LBH-TZ1703 O We O thank O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21504105 O 21444007 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20130345 O BK20130008 B-AWARD Open B-ORG Project I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Physical I-ORG Chemistry I-ORG of I-ORG Solid I-ORG Surfaces I-ORG in I-ORG Xiamen I-ORG University I-ORG 201201 O Initial O Fund O for O Talents O of O Fuzhou O University O XRC-1542 O and O Opening B-ORG Measuring I-ORG Fund I-ORG of I-ORG Precious I-ORG Apparatus I-ORG of I-ORG Fuzhou I-ORG University I-ORG 2016T031 O for O their O financial O support O Authors O are O supported O by O a O National B-ORG Institutes I-ORG of I-ORG Health I-ORG K12HD068371 B-AWARD BL) O and O a O Burroughs B-ORG Wellcome I-ORG Fund I-ORG Clinical O Scientist O Award O in O Translational O Research O 1008496 B-AWARD an O American B-ORG Heart I-ORG Association I-ORG Established O Investigator O Award O 13EIA13460001 B-AWARD March B-ORG of I-ORG Dimes I-ORG Foundation I-ORG 6-FY13-167 B-AWARD and O the O Indiana O University O Health O – O Indiana O University O School O of O Medicine O Strategic O Research O Initiative O and O Physician O Scientist O Initiative O SW O This O research O was O funded O by O grants O from O the O Inner B-ORG Mongolia I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG No. O 2019ZD08 B-AWARD 2019ZD031 B-AWARD 2020ZD0007 B-AWARD and O 2021ZD0024 B-AWARD the O Xilingol B-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG No. O 202002 B-AWARD and O 202120 B-AWARD the O State B-ORG Key I-ORG Laboratory I-ORG for I-ORG Reproductive I-ORG Regulation I-ORG and I-ORG Breeding I-ORG of I-ORG Grassland I-ORG Livestock I-ORG 2021ZZ0204 O the O “Grassland B-ORG Talents” I-ORG Scholars I-ORG Program I-ORG CYYC6068 O of O the O Inner O Mongolia O Autonomous O Region O China O the O High-level O Talents O Import O Program O of O Inner B-ORG Mongolia I-ORG University I-ORG No. O 21400-5165112 B-AWARD China O and O the O High O Level O Overseas O Talents O Project O [2018 O No. I-AWARD 190 O from O the O Ministry B-ORG of I-ORG Human I-ORG Resources I-ORG and I-ORG Social I-ORG Security I-ORG China O the O agricultural O breeding O special O project O “Tan B-ORG sheep I-ORG line I-ORG breeding” I-ORG of I-ORG the I-ORG Ningxia I-ORG Hui I-ORG Autonomous I-ORG Region I-ORG 2013NYYZ04 O China O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31802158 O Chongqing B-ORG Research I-ORG Program I-ORG of I-ORG Basic I-ORG Research I-ORG and I-ORG Frontier I-ORG Technology I-ORG cstc2017jcyjAX0361 O and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG XDJK2019C093 O This O work O was O supported O by O grants O from O the O Project B-ORG of I-ORG China I-ORG Agriculuture I-ORG Research I-ORG System I-ORG CARS-06-13.5-A28 O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG Shanxi I-ORG Province I-ORG 201703D211007 O the O Key B-ORG Scientific I-ORG and I-ORG Technological I-ORG Project I-ORG of I-ORG Shanxi I-ORG Province I-ORG 2015-TN-09 O Science B-ORG I-ORG Technology I-ORG Innovation I-ORG Foundation I-ORG of I-ORG Shanxi I-ORG Agricultural I-ORG University I-ORG 2016YJ05 O the O Program B-ORG for I-ORG the I-ORG Top I-ORG Young I-ORG Innovative I-ORG Talents I-ORG of I-ORG Shanxi I-ORG Agricultural I-ORG University I-ORG TYIT201406 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O received O funding O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 11601324 B-AWARD and O 62175037 B-AWARD the O Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Action I-ORG Plan I-ORG No. O 20JC1416500 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG No. O 15zr1420800 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31470693 O 31100503 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG LY18C160006 O the B-ORG Central I-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG 1610212018004 O 1610212016017 B-AWARD and O the B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG CAAS-ASTIP-2014-TRICAAS O This O study O was O supported O by O a O grant O from O the O Ministry B-ORG of I-ORG Health I-ORG Labour I-ORG and I-ORG Welfare I-ORG of O Japan O for O Research O on O Rare O Intractable O Diseases O in O the O Kidney O and O Urinary O Tract O H24-nanchitou O nan)-ippan-041 I-AWARD to O Kazumoto O Iijima O in O the O “Research O on O Measures O for O Intractable O Diseases” O Project O Grants-in-Aid O for O Scientific O Research O KAKENHI O from O the O Ministry B-ORG of I-ORG Education I-ORG Culture I-ORG Sports I-ORG Science I-ORG and I-ORG Technology I-ORG of O Japan O subject O ID: O 15K09691 B-AWARD to O Kandai O Nozu O and O 17H04189 B-AWARD to O Kazumoto O Iijima O and O a O Grant O from O the O Japan B-ORG Agency I-ORG for I-ORG Medical I-ORG Research I-ORG and I-ORG Development O AMED O subject O ID: O 7930006 B-AWARD to O Kandai O Nozu O This O research O was O funded O by O the O Heilongjiang B-ORG Province I-ORG million I-ORG project I-ORG 2021ZX12B02 O Key B-ORG and I-ORG R&D I-ORG projects I-ORG in I-ORG Shandong I-ORG Province I-ORG 2022CXGC010603 O the O National B-ORG key I-ORG R&D I-ORG plan I-ORG 2021YFD2100401 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 32202228 O the O Heilongjiang B-ORG Province I-ORG key I-ORG R&D I-ORG plan I-ORG GA21B001 O the O Heilongjiang B-ORG Province I-ORG Major I-ORG Achievements I-ORG Transformation I-ORG Project I-ORG CG19A002 O and O the O China B-ORG Fund I-ORG on I-ORG the I-ORG surface I-ORG of I-ORG a I-ORG postdoctoral I-ORG project I-ORG 2022M721995 O This O study O was O funded O by O an O Open B-ORG Project I-ORG of I-ORG the I-ORG Key I-ORG Laboratory I-ORG of I-ORG Grassland I-ORG Ecosystem I-ORG Gansu I-ORG Agricultural I-ORG University I-ORG Ministry I-ORG of I-ORG Education I-ORG KLGE202204 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32272566 O the O Industrial B-ORG Support I-ORG Program I-ORG Project I-ORG 2022CYZC-47 O of O Gansu O Provincial O Education O Department O the O Technology B-ORG Support I-ORG Program I-ORG of I-ORG Gansu I-ORG Forestry I-ORG and I-ORG Grassland I-ORG Administration I-ORG LCJ20210020 O the O Funding B-ORG for I-ORG Discipline I-ORG team I-ORG Construction I-ORG of I-ORG Gansu I-ORG Agricultural I-ORG University I-ORG 2500011004 O This O work O was O supported O by O grants O fromNatural O Sciences I-ORG and I-ORG Engineering I-ORG Research I-ORG Council I-ORG of I-ORG Canada I-ORG NSERC I-ORG CGS;443206-2013to O E.C O and O Discovery O Grant312201-2010to O L.J.C.),Fonds O Québecois I-ORG de I-ORG la I-ORG Recherche I-ORG sur I-ORG la I-ORG Nature I-ORG et I-ORG les I-ORG Technologies(176498-2013to O E.C.),McGill O University(00286to O E.C O andCanada O Research I-ORG Chair I-ORG research I-ORG funds(950-228 O 344to O L.J.C O This O study O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31701155 O the O Chinese B-ORG PLA I-ORG General I-ORG Hospital I-ORG Medical I-ORG large I-ORG data I-ORG project I-ORG No.2016MBD-002 O the O Chinese B-ORG PLA I-ORG General I-ORG Hospital I-ORG Translational I-ORG Medicine I-ORG Project I-ORG No.2016-TM-013 O and O the O Biological B-ORG Medicine I-ORG and I-ORG Life I-ORG Science I-ORG Cultivation I-ORG Foundation I-ORG of I-ORG Beijing I-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG No.Z151100003915075 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O Open B-ORG Foundation I-ORG of I-ORG Key I-ORG Laboratory I-ORG of I-ORG Parasite I-ORG and I-ORG Vector I-ORG Biology I-ORG Ministry I-ORG of I-ORG Health I-ORG grant O No. O WSBKFKT-201603 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81460507 B-AWARD Key B-ORG Laboratory I-ORG Program I-ORG of I-ORG Jiangxi I-ORG Province I-ORG 20192BCD40006 O Jiangxi B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG 20203BBGL73168 O Science B-ORG and I-ORG technology I-ORG plan I-ORG of I-ORG Jiangxi I-ORG Provincial I-ORG Health I-ORG Commission I-ORG 202211332 O and O 20201116 B-AWARD and O Leading B-ORG discipline I-ORG program I-ORG in I-ORG Jiangxi I-ORG Province I-ORG Item I-ORG 2021030107 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O paper O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O numbers O 32073008 B-AWARD and O 32273170 B-AWARD the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China O grant O number O 2020YFD0900900 B-AWARD the O 2020 B-ORG Li I-ORG Ka I-ORG Shing I-ORG Foundation I-ORG Cross-Disciplinary I-ORG Research I-ORG Grant O grant O number O 2020LKSFG01E B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O grant O number O 2214050002866 B-AWARD The O APC O was O funded O by O the O National O Natural O Science O Foundation O of O China O This O work O was O supported O by O the O Deutsche B-ORG Forschungsgemeinschaft I-ORG grant O no. O MA-1426/21-1 B-AWARD the O European B-ORG Research I-ORG Council I-ORG grant O no. O 666053 B-AWARD and O the O Volkswagen B-ORG Foundation I-ORG grant O no. O 93046 B-AWARD This O work O was O supported O in O part O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grants O 61833016 B-AWARD and O 6227814 B-AWARD the O Shaanxi B-ORG Outstanding I-ORG Youth I-ORG Science I-ORG Foundation I-ORG under O Grant O 2020JC-34 B-AWARD and O the O Shaanxi B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Team I-ORG under O Grant O No. O 2022TD-24 B-AWARD This O research O was O supported O byCancer O Research I-ORG UK[Grant O C570/A16491],Medical B-AWARD Research I-ORG Council(Grant O MR/K02700X/1 B-AWARD and O Oxford O University O BHF O Centre O of O Research O Excellence O British O Heart I-ORG Foundationgrant O RE/13/1/30181 B-AWARD to O B.J.C O This O work O was O supported O by O grants O from O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2018YFD0501605 O 2016YFD0500507 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2662018PY079 O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Animal I-ORG Nutrition I-ORG Open I-ORG Program I-ORG 2004DA125184F1721 O The O authors O gratefully O acknowledge O the O key O research O and O development O program O of O Shandong O Province O 2021ZLGX01 O the O financial O support O from O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2021QE229 O China B-ORG Postdoctoral I-ORG Science I-ORG foundation I-ORG 2022M710077 O and O Taishan B-ORG Scholar I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG This O study O was O supported O China B-ORG Medical I-ORG University I-ORG by O grant O CMU107-N-07 B-AWARD for O Dr. O Hsu O the B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology O grant O 102-2320-B-038-039-MY3 B-AWARD for O Dr. O Lee O and O the B-ORG Health I-ORG and I-ORG welfare I-ORG surcharge I-ORG of I-ORG tobacco I-ORG products I-ORG grant O MOHW107-TDU-B-212-114014 B-AWARD for O Dr. O Lee O Meanwhile O this O study O was O financially O supported O by O the O “TMU O Research O Center O of O Cancer O Translational O Medicine” O from O The O Featured O Areas O Research O Center O Program O within O the O framework O of O the O Higher O Education O Sprout O Project O by O the O Ministry O of O Education O MOE O in O Taiwan O None O of O the O funding O bodies O were O involved O in O the O design O of O the O study O the O collection O analysis O and O interpretation O of O the O data O or O the O writing O of O the O manuscript O The O study O was O supported O by O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG in I-ORG Tibet I-ORG Autonomous I-ORG Region I-ORG XZ202201ZY0004N O the O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Gansu I-ORG Province I-ORG 22JR5RA463 O and O the O Special B-ORG Item I-ORG of I-ORG Regional I-ORG Collaborative I-ORG Innovation I-ORG in I-ORG Tibet I-ORG Autonomous I-ORG Region I-ORG QYXTZX-LS2021-01 O This O work O was O supported O by O grants O to O C.E.B O from O Cystic B-ORG Fibrosis I-ORG Canada I-ORG CFC O 3172 O and O from O the O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG CIHR O MOP-125855 O and O to O C.M.D O from O Cystic O Fibrosis O Canada O CFC O 480991 O and O from O the O Natural B-ORG Sciences I-ORG and I-ORG Engineering I-ORG Research I-ORG Council I-ORG of I-ORG Canada I-ORG NSERC O Discovery O grant O RGPIN-2016-05577 O The O work O was O funded O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC1001401 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31590832 O 31771633 O 81100423 B-AWARD and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20150320 O This O work O was O supported O by: O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31701329 B-AWARD 81573530 O Fujian-Taiwan B-ORG Joint I-ORG Innovative I-ORG Center I-ORG for I-ORG Germplasm I-ORG Resources I-ORG and I-ORG Cultivation I-ORG of I-ORG Crop I-ORG Fujian O 2011 O Program O No.2015-75 O China O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG No. O 2016J01100 B-AWARD and O the O Project B-ORG Funded I-ORG by I-ORG China I-ORG Postdoral I-ORG Science I-ORG Foundation I-ORG No. O 2015M580560 B-AWARD This O research O was O funded O by O the O Jiangsu B-ORG Maternal I-ORG and I-ORG Child I-ORG Health I-ORG Research I-ORG Project I-ORG F202144 O Zhenjiang B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Fund I-ORG Key O R&D O Plan—Social O development O SH2022098 B-AWARD the O Jiangsu B-ORG Province I-ORG and I-ORG Education I-ORG Ministry I-ORG Co-sponsored I-ORG Synergistic I-ORG Innovation I-ORG Center I-ORG of I-ORG Modern I-ORG Agricultural I-ORG Equipment I-ORG of I-ORG China I-ORG XTCX2026 O and O the O National B-ORG Foreign I-ORG Experts I-ORG Program I-ORG Project I-ORG of I-ORG China I-ORG G2022014094L O and O DL2022014006L B-AWARD The O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 52000127 O the B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Xi’an I-ORG 22GXFW0018 O and O 2017071CG/RC034(SXSF002 O the O China B-ORG Scholarship I-ORG Council I-ORG 201906875037 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 2017JQ5074 O This O work O was O supported O by O ERC O Advanced O Grants O from O the O Ideas O programme O of O the O European O Union O Seventh B-ORG Framework I-ORG Programme I-ORG AdvG-2012-321670 O and O Horizon B-ORG 2020 I-ORG Programme O AdvG-2017-785809 O to O G.V.d.B O by O the O Methusalem B-ORG programme I-ORG of I-ORG the I-ORG Flemish I-ORG Government I-ORG through O the O University O of O Leuven O to O G.V.d.B O and O I.V O Ilse O Vanhorebeek O METH14/06 B-AWARD and O by O the O Agency O for O Innovation O through O Science O and O Technology O Flanders O Belgium O through O the O University O of O Leuven O to O G.V.d.B O IWT/070695/TBM B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No.2017YFC1310500 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81671402 O and O the O Shanghai B-ORG Science I-ORG Technology I-ORG Committee I-ORG No.15411961400 O This O research O is O funded O by O the O Youth B-ORG Project I-ORG of I-ORG the I-ORG National I-ORG Social I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 15CTQ023 B-AWARD to O FW, O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O No. O 9174029 B-AWARD to O FW, O General B-ORG Project I-ORG of I-ORG Beijing I-ORG Education I-ORG Commission I-ORG Social I-ORG Science I-ORG Grant O No. O SM201610005002 B-AWARD to O FW, O and O the O 15th B-ORG Graduate I-ORG Science I-ORG and I-ORG Technology I-ORG Fund I-ORG Project I-ORG of I-ORG Beijing I-ORG University I-ORG of I-ORG Technology I-ORG Grant O No. O ykj-2016-00326 B-AWARD to O XW. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The B-ORG National I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31500308 O the O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG LQ16C040001 O and O the O Zhejiang B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG for I-ORG College I-ORG Students I-ORG 2019R434006 O funded O this O work O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O National B-ORG Institute I-ORG of I-ORG Biological I-ORG Resources I-ORG NIBR201922101 O the O Next-Generation O Biogreen21 O program O PJ013194 O Rural B-ORG Development I-ORG Administration O Korea O and O the O Myongji B-ORG University I-ORG Research I-ORG Year I-ORG Grant I-ORG 2020 O The O funding O bodies O played O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O The O study O was O supported O by O the O Grants-in-Aid B-ORG for I-ORG Scientific I-ORG Research I-ORG A) I-ORG from I-ORG the I-ORG Japan I-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG JSPS O Grant O No. O 16H02590 B-AWARD This O research O was O also O supported O by O grants O from O the B-ORG Project I-ORG of I-ORG the I-ORG NARO I-ORG Bio-oriented I-ORG Technology I-ORG Research I-ORG Advancement I-ORG Institution I-ORG the I-ORG Special I-ORG Scheme I-ORG Project I-ORG on I-ORG Regional I-ORG Developing I-ORG Strategy I-ORG Grant O No. O 16817983 B-AWARD and O the O Special B-ORG Scheme I-ORG Project I-ORG on I-ORG Vitalizing I-ORG Management I-ORG Entities I-ORG of I-ORG Agriculture I-ORG Forestry I-ORG and I-ORG Fisheries I-ORG Grant O No. O 16930548 B-AWARD Kyaw O Kyaw O Moe O is O a O JSPS O International O Research O Fellow O FY2018 O Invitational O Fellowship O for O Research O in O Japan O Long-term O RV O received O support O from O CAPES B-ORG Brazilian O Federal O Agency O for O Support O and O Evaluation O of O Graduate O Education O BEX O 10615/14-8 O www.iie.org/programs/capes O PNM O JM O PM O appreciate O funding O from O the O USDA-ARS B-ORG National B-AWARD Sclerotinia I-AWARD Initiative I-AWARD https://www.ars.usda.gov/plains-area/docs/white-mold-research/research O PM O QS O appreciate O funding O from O the O USDA B-ORG National I-ORG Institute I-ORG of I-ORG Food I-ORG and I-ORG Agricultural I-ORG NIFA I-ORG Agriculture I-ORG and I-ORG Food I-ORG Research I-ORG Initiative I-ORG AFRI I-ORG Project I-ORG 2009-0192 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O project O was O supported O by O the B-ORG National I-ORG Key I-ORG research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFA0900302 O the B-ORG National I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31970045 O the B-ORG Program I-ORG for I-ORG Advanced I-ORG Talents I-ORG within I-ORG Six I-ORG Industries I-ORG of I-ORG Jiangsu I-ORG Province I-ORG 2015-SWYY-010 O the B-ORG National I-ORG First-class I-ORG Discipline I-ORG Program I-ORG of I-ORG Light I-ORG Industry I-ORG Technology I-ORG and I-ORG Engineering I-ORG LITE2018-12 O the B-ORG Program I-ORG of I-ORG Introducing I-ORG Talents I-ORG of I-ORG Discipline I-ORG to I-ORG Universities I-ORG 111-2-06 O and O Top-notch O Academic O Programs O Project O of O Jiangsu O Higher O Education O Institutions O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81773696 B-AWARD and O 81473183 B-AWARD the B-ORG Postgraduate I-ORG Research I-ORG I-ORG Practice I-ORG Innovation I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG KYCX17_2042 O and O the O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG the I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutes I-ORG PAPD O This O work O was O supported O by O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG ASTIP-TRIC04 O the O Key B-ORG S&T I-ORG project I-ORG of I-ORG China I-ORG National I-ORG Tobacco I-ORG Corporation I-ORG 110201601022(LS-02 O and O the O Science B-ORG Foundation I-ORG for I-ORG Young I-ORG Scholars I-ORG of I-ORG Institute I-ORG of I-ORG Tobacco I-ORG Research I-ORG of I-ORG CAAS I-ORG 2015B03 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O National B-ORG Institutes I-ORG of I-ORG Health I-ORG R01GM052426 O to O J.J.H O T32GM068411 B-AWARD to O K.J.M O JSPS B-ORG KAKENHI O JP18H05534 O to O H.K O Platform O Project O for O Supporting O Drug O Discovery O and O Life O Science O Research O BINDS O from O AMED B-ORG JP20am0101076 O to O H.K O JST B-ORG ERATO O JPMJER1901 O to O H.K O JST O PRESTO O JPMJPR19K6 O to O G.H O Funding O for O open O access O charge O NIH O R01GM052426 O This O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81471365 O Beijing O Municipal O Science O O Tech O Commission O Z161100002616017 O Beijing B-ORG Institute I-ORG for I-ORG Brain I-ORG Disorders I-ORG PXM2015_014226_000051 O Beijing B-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospitals I-ORG ZYLX201403 O and I-AWARD 2011-2012-02 O This O study O was O funded O by O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG 304184 O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG 001 O and O Hospital B-ORG de I-ORG Clínicas I-ORG de I-ORG Porto I-ORG Alegre I-ORG 2016 O This O work O was O funded O by O the O Ministerio O de O Ciencia O Innovación O y O Universidades O of O Spain O and O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III I-ORG PI16/00528 O PI16/00946 B-AWARD PI16/01207 B-AWARD and O PI16/01276 B-AWARD co-funded O by O the O Spanish B-ORG Biobank I-ORG Network I-ORG PT13/0010/0030 O PT17/0015/0001 B-AWARD PT17/0015/0021 B-AWARD PT17/0015/0049 B-AWARD PT17/0015/0018 B-AWARD PT17/0015/0002 B-AWARD PT17/0015/0016 B-AWARD PT17/0015/0038 B-AWARD PT17/0015/0027 B-AWARD PT17/0015/0004 B-AWARD PT17/0015/0047 B-AWARD PT17/0015/0014 B-AWARD PT17/0015/0041 B-AWARD and O PT17/0015/0006 B-AWARD European O Regional O Development O Fund O FEDER O “A O way O to O make O Europe” O and O granted O by O Conselleria B-ORG d’Innovació I-ORG Recerca I-ORG i I-ORG Turisme I-ORG del I-ORG Govern I-ORG de I-ORG les I-ORG Illes I-ORG Balears I-ORG TEC/002/2017 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51905445 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 2018JQ5020 O and O Fundamental B-ORG Research I-ORG Funds I-ORG of I-ORG the I-ORG Central I-ORG Universities I-ORG 31020190503005 O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences O GM094513-01 B-AWARD Defense B-ORG Advanced I-ORG Research I-ORG Projects I-ORG Agency O BC110089 B-AWARD American B-ORG Heart I-ORG Association O 16PRE27510016 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 61704034 B-AWARD the O Key B-ORG Platforms I-ORG and I-ORG Research I-ORG Projects I-ORG of I-ORG Department I-ORG of I-ORG Education I-ORG of I-ORG Guangdong I-ORG Province I-ORG Grant O No. O 2016KTSCX034 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG Grant O No. O 2018A0303130199 B-AWARD and I-AWARD 2017A030313632 O This O work O is O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Stem I-ORG Cell I-ORG and I-ORG Translation I-ORG Research I-ORG NO. O 2016YFA0102000 B-AWARD to O C.-W.D O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO. O 81570121 B-AWARD to O C.-W.D O NO. O 31530017 B-AWARD and O 81372349 B-AWARD to O B.-B.Z O NO. O 81500112 B-AWARD to O H.L O and O The B-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Pudong I-ORG District I-ORG Shanghai I-ORG Municipality I-ORG NO. O PKJ2015-Y04 B-AWARD to O C.-W.D O and O by O Innovation B-ORG Program I-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Education I-ORG Commission I-ORG NO. O 15ZZ052 B-AWARD to O C.-W.D O This O work O was O partly O supported O by O the O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81672797 O and I-AWARD 81472612 O the B-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Beijing I-ORG City I-ORG Z151100003915076 O the O Beijing B-ORG Nova I-ORG Program I-ORG Interdisciplinary I-ORG Studies I-ORG Cooperative I-ORG Project I-ORG Z161100004916043 O and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC1303501 O and I-AWARD 2016YFC1303504 O This O study O was O supported O by O grants O from O the O Scientific B-ORG and I-ORG technological I-ORG innovation I-ORG joint I-ORG capital I-ORG projects I-ORG of I-ORG Fujian I-ORG Province I-ORG 2016Y9031),Construction O Project I-ORG of I-ORG Fujian I-ORG Province I-ORG Minimally I-ORG Invasive I-ORG Medical I-ORG Center I-ORG No. O 2017]171),The O second I-ORG batch I-ORG of I-ORG special I-ORG support I-ORG funds I-ORG for I-ORG Fujian I-ORG Province I-ORG innovation I-ORG and I-ORG entrepreneurship I-ORG talents I-ORG 2016B013),Youth B-AWARD scientific I-ORG research I-ORG subject I-ORG of I-ORG Fujian I-ORG provincial I-ORG health I-ORG and I-ORG family I-ORG planning I-ORG commission I-ORG No. O 2015-1-37),QIHANG O funds I-ORG of I-ORG Fujian I-ORG Medical I-ORG University I-ORG No.2016QH025 O These O funding O bodies O had O no O involvement O in O the O design O of O the O study O collection O analysis O and O interpretation O of O data O or O writing O of O the O manuscript O This O work O was O supported O by O the O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG Nos O 19PJ1408600 B-AWARD Shanghai O Pujiang O Program O 18142202100 B-AWARD 17JC1400804 B-AWARD CAS B-ORG Key I-ORG Laboratory I-ORG of I-ORG Interfacial I-ORG Physics I-ORG and I-ORG Technology I-ORG CASKL-IPT1702 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Nos O 3290008414 B-AWARD 3290008413 B-AWARD The O funding O agencies O had O no O role O in O study O design O data O collection O data O analysis O interpretation O and O writing O of O the O manuscript O E.B O A.J.P.B O and O A.W O are O supported O by O the O Wellcome B-ORG Trust I-ORG Strategic O Award O grant O 097377 B-AWARD and O the O MRC O Centre O for O Medical O Mycology O grant O MR/N006364/2 B-AWARD at O the O University O of O Aberdeen O AB O was O also O supported O by O the O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG BBSRC O BB/K017365/1 O and O the O Medical B-ORG Research I-ORG Council I-ORG MR/M026663/1 O The O work O in O this O paper O is O funded O by O a O BBSRC O EASTBIO O grant O BB/M010996/1 O awarded O to O AW. O National B-ORG Science I-ORG Centre O Poland O 2013/11/13/NZ1/00089 O 2013/09/N/NZ1/01103 B-AWARD to O M.S O 2014/12/W/NZ1/00463 B-AWARD to O M.N O POIR.04.04.00-00-5E63/18-00 O project O to O R.J.S O within O the O First O TEAM O program O of O the O Foundation O for O Polish O Science O co-financed O by O the O European O Union O under O the O European B-ORG Regional I-ORG Development I-ORG Fund O the O experiments O were O performed O using O the O CePT O infrastructure O financed O by O the O European O Union O European O Regional O Development O Fund O Innovative O Economy O 2007–13 O agreement O no. O POIG.02.02.00-14-024/08-00 B-AWARD Next O Generation O Sequencing O Platform O at O the O International B-ORG Institute I-ORG of I-ORG Molecular I-ORG and I-ORG Cell I-ORG Biology I-ORG in I-ORG Warsaw I-ORG 6405/IA/1789/2014 O Funding O for O open O access O charge O POIR.04.04.00-00-5E63/18-00 O project O Foundation O for O Polish O Science O This O study O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanxi I-ORG Province I-ORG 201701D21059 O an B-ORG Art I-ORG Disciplinary I-ORG Project I-ORG of I-ORG Shanxi I-ORG Province I-ORG 2017F06 O and O the O 13th B-ORG Five-Year I-ORG Education I-ORG Science I-ORG Project I-ORG of I-ORG Shanxi I-ORG Province I-ORG GH-17059 O and O the O Special O Projects O for O the O Platform O and O Talents O of O Xinzhou O 20180601 O The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Key B-ORG Research I-ORG Program I-ORG of I-ORG Frontier I-ORG Sciences I-ORG of I-ORG CAS O grant O number O ZDBS-LY-SM024 B-AWARD The B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China O grant O number O 2019YFA0110302 B-AWARD the O General B-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 32270879 B-AWARD International B-ORG Science I-ORG and I-ORG Technology I-ORG Cooperation I-ORG Project I-ORG re-innovation I-ORG industrialization I-ORG 2012C14028 O National B-ORG Natural I-ORG Science I-ORG Fund I-ORG 81201782 O Medical B-ORG and I-ORG Health I-ORG science I-ORG and I-ORG technology I-ORG project I-ORG in I-ORG Zhejiang I-ORG province I-ORG 2014KYB085 O The O authors O gratefully O acknowledge O the O financial O support O of O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31271925 O the O Special B-ORG Project I-ORG on I-ORG the I-ORG Integration I-ORG of I-ORG Industry I-ORG Education I-ORG and I-ORG Research I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG No. O 2013B090600015 O and O the O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG China I-ORG No. O 2014J4100192 O This O study O was O supported O by O the O Biostatistics O Core O of O the O University O of O Minnesota O Masonic O Cancer O Center O funded O by O the O National B-ORG Cancer I-ORG Institute I-ORG 5P30CA077598 O to O CTL O and O XL, O by O the O National B-ORG Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute I-ORG 5R01HL094183 O to O JLT O JSA O and O XL, O and O by O the O Clinical O and O Translational O Science O Institute O of O University O of O Minnesota O National O Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences I-ORG UL1TR002494 B-AWARD The O funding O body O played O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and/or O in O writing O the O manuscript O This O work O was O supported O by O the B-ORG National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Number O 71473202 B-AWARD the O National O Natural O Science O Foundation O of O China O Grant O Number O 71463007 B-AWARD and O the O National B-ORG Social I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Number O 16BGL097 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81173107];Science O and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG 2013B021100018];Industry-university-research O Collaborative I-ORG Innovation I-ORG Major I-ORG Projects I-ORG of I-ORG Guangzhou I-ORG Science I-ORG Technology I-ORG Innovation I-ORG Commission I-ORG 201604020164 O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32025032 O the O Youth B-ORG Innovation I-ORG Promotion I-ORG Association I-ORG CAS I-ORG 2022078 O and O the O Agricultural B-ORG Breeding I-ORG Project I-ORG of I-ORG Ningxia I-ORG Hui I-ORG Autonomous I-ORG Region I-ORG NXNYYZ20210104 O This O study O was O supported O by O the O Research B-ORG Program I-ORG Sponsored I-ORG by I-ORG Gansu I-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Aridland I-ORG Crop I-ORG Science I-ORG Gansu I-ORG Agricultural I-ORG University I-ORG GSCS-2017-3 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31760407 O China B-ORG Agriculture I-ORG Research I-ORG System-Potato I-ORG CARS-09-P14 O Biological B-ORG Technology I-ORG Fund I-ORG of I-ORG Gansu I-ORG province I-ORG of I-ORG China I-ORG GNSW-2016-27 O Special B-ORG funds I-ORG for I-ORG discipline I-ORG construction I-ORG of I-ORG Gansu I-ORG Agricultural I-ORG University I-ORG GSAU-XKJS-2018-161 O The O funding O agency O was O not O involved O in O the O design O of O the O study O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31271721 O and O 31571661 B-AWARD the O Committee B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Fuling I-ORG of I-ORG Chongqing I-ORG FLKJ-2015ABB1048 O and O Chongqing B-ORG Industry I-ORG and I-ORG Trade I-ORG Polytechnic I-ORG ZR201507 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O research O was O supported O by O the O following O grants O JSPS B-ORG KAKENHI I-ORG No. O 25460546 B-AWARD MW,https://www.jsps.go.jp/english/index.html O Research B-ORG on I-ORG Emerging I-ORG and I-ORG Re-emerging I-ORG Infectious I-ORG Diseases I-ORG from I-ORG the I-ORG Ministry I-ORG of I-ORG Health I-ORG Labor I-ORG and I-ORG Welfare I-ORG of I-ORG Japan I-ORG No. O 14525508 B-AWARD KK,http://www.mhlw.go.jp/english O Research B-ORG Program I-ORG on I-ORG Emerging I-ORG and I-ORG Re-emerging I-ORG Infectious I-ORG Diseases I-ORG from I-ORG the I-ORG Japan I-ORG Agency I-ORG for I-ORG Medical I-ORG Research I-ORG and I-ORG Development I-ORG AMED I-ORG No. O 26361101 B-AWARD KK,http://www.amed.go.jp/en O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O original O studies O or O specimen O analyses O were O funded O through O the O Australian B-ORG National I-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG NHMRC O grant I-AWARD numbers I-AWARD 212044 I-AWARD 436023 I-AWARD 100009 I-AWARD 1023781 O and O Studies O 3–4 O through O two O Healthway B-ORG grants O grant O numbers I-AWARD 6028 I-AWARD and I-AWARD 10564 O The O Darwin O component O of O the O paper O is O associated O with O an O NHMRC B-ORG Centre I-ORG for I-ORG Research I-ORG Excellence I-ORG in I-ORG Otitis I-ORG Media I-ORG of I-ORG Aboriginal I-ORG and I-ORG Torres I-ORG Strait I-ORG Islander I-ORG Children I-ORG grant O number I-AWARD 1078557 O and O an O NHMRC O Centre O for O Research O Excellence O in O Lung O Health O of O Aboriginal O and O Torres O Strait O Islander O Children O grant O number O 1040830 O RM O is O supported O by O NHMRC O Frank O Fenner O Early O Career O Fellowship O 1034703 O DL O was O funded O through O NHMRC O program O grant O number O 353514 O AC O is O supported O by O NHMRC O Practitioner O Fellowship O 545216 O AL O is O supported O by O NHMRC O Elizabeth O Blackburn O Research O Fellowship O 1020561 O KH O is O supported O by O NHMRC O Early O Career O Fellowship O 1072870 O The O funders O had O no O role O in O study O design O collection O and O analysis O of O data O decision O to O publish O or O writing O of O the O manuscript O This O work O was O supported O by O the O Austrian B-ORG Science I-ORG Fund I-ORG V O 569-N31 O Austrian B-ORG Research I-ORG Promotion I-ORG Agency I-ORG FFG O 845638 O European B-ORG Union’s I-ORG H2020 I-ORG Programme I-ORG 645751 O Spanish B-ORG R&D&I I-ORG Programme I-ORG TIN2015–70560 O Andalusian B-ORG R&D&I I-ORG Programme I-ORG P12–TIC-1867 O This O work O was O supported O by O the O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31370135 O the O Fundamental B-ORG Research I-ORG Funds I-ORG of I-ORG Shandong I-ORG University I-ORG No. O 2015JC005 O and O the O Science B-ORG and I-ORG Technology I-ORG for I-ORG Department I-ORG of I-ORG Shandong I-ORG Province I-ORG 2014GGE27075 O This O work O was O supported O by O grants O from O the B-ORG Medical I-ORG and I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG I-ORG Youth I-ORG Talent I-ORG Project I-ORG Grant O No: O 2019RC018 B-AWARD 2019330974 O the O Chinese B-ORG Medicine I-ORG Research I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Province I-ORG Grant O No: O 2016ZB016 B-AWARD and O the O Medical B-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Provincial I-ORG Health I-ORG Commission I-ORG Grant O No: O 2017KY200 B-AWARD This O study O was O supported O by O the O Foundation B-ORG for I-ORG Innovative I-ORG Research I-ORG Team I-ORG of I-ORG Hubei I-ORG University I-ORG of I-ORG Medicine I-ORG Grant O Number O FDFR201603 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Number O 81802046 B-AWARD the O Education B-ORG Agency I-ORG Major I-ORG Project I-ORG of I-ORG Hubei I-ORG Province I-ORG of I-ORG China I-ORG Grant O Number O D20162101 B-AWARD and O Innovation B-ORG and I-ORG Entrepreneurship I-ORG Training I-ORG Program I-ORG for I-ORG College I-ORG Students I-ORG Grant O Number O 201710929040 B-AWARD the O cost O of O experiments O comes O from O these O funding O The O funder O only O provided O economic O support O and O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O Education B-ORG Department I-ORG of I-ORG Jilin I-ORG Province I-ORG grant O No. O JJKH20190032KJ B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grants O Nos O 81671177 B-AWARD and I-AWARD 31401123 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jilin I-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Plan I-ORG Project I-ORG No. O 20190201043JC B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31771595 O 31701244 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 20002150001 O 22120180549 B-AWARD Natural B-ORG Science I-ORG Fund I-ORG of I-ORG Hebei I-ORG Province I-ORG of I-ORG China I-ORG C2018209119 O Scientific B-ORG and I-ORG Technological I-ORG Research I-ORG Project I-ORG of I-ORG Higher I-ORG Education I-ORG of I-ORG Hebei I-ORG Province I-ORG BJ2019040 O and O Doctoral B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG North I-ORG China I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG BS2017063 O This O work O was O supported O by O USAID B-ORG AID-BFS-P-13-00002 B-AWARD the O Bill B-ORG and I-ORG Melinda I-ORG Gates I-ORG Foundation I-ORG grant O OPP1078791 B-AWARD and O USDA B-ORG ARS I-ORG CRIS I-ORG project I-ORG 5348-32000-034-00D O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81573948 I-AWARD and O No. B-AWARD 81874390 O Shanghai B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 21ZR1464100 O Special O Project O for O Biomedical O Science O and O Technology O Support O of O the O “Science O and O Technology O Innovation O Action O Plan” O of O Shanghai O Science O and O Technology O Commission O in O 2022 O No. O 22S11901700 O and O the B-ORG Shanghai I-ORG Key I-ORG Specialty I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Clinical I-ORG Medicine I-ORG No. O shslczdzk01201 O The O funding O bodies O played O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O study O was O supported O by O research O grants O to O Dr. O Hon-Yen O Wu O from O the O National B-ORG Health I-ORG Research I-ORG Institutes I-ORG Taiwan I-ORG NHRI-EX106-10510PC O NHRI-EX107-10510PC B-AWARD and O the O Far B-ORG Eastern I-ORG Memorial I-ORG Hospital I-ORG New I-ORG Taipei I-ORG City I-ORG Taiwan I-ORG FEMH-EX106-10510PC O FEMH-EX107-10510PC B-AWARD as O well O as O by O research O grants O to O Dr. O Mei-Ju O Ko O from O the O Department B-ORG of I-ORG Health I-ORG Taipei I-ORG City I-ORG Government I-ORG Taipei I-ORG Taiwan I-ORG 10301-62-030 O 10501-62-004 B-AWARD and O Taipei B-ORG City I-ORG Hospital I-ORG Ren-Ai I-ORG Branch I-ORG Taipei I-ORG Taiwan I-ORG No.15 O 2015 O No.14 B-AWARD 2016 O The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O financially O supported O by O the O Heilongjiang B-ORG Province I-ORG Postdoctoral I-ORG Research I-ORG Startup I-ORG Fund I-ORG LBH-Q20066 O Innovation O of O Specific O Japonica O Rice O Varieties O in O Northeast O China O Key B-ORG Research I-ORG I-ORG Development I-ORG Program I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG GA21B002 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 32101748 B-AWARD the B-ORG Extension I-ORG of I-ORG Chinese I-ORG Mitten I-ORG Crab I-ORG Eriocheir I-ORG Sinensis I-ORG Aquaculture I-ORG Technology I-ORG that O was O found O from O Shanghai O Agricultural O Commission O grant O number O 2015D1-7 B-AWARD the B-ORG Aquaculture I-ORG Engineering I-ORG Research I-ORG Platform I-ORG in O Shanghai O Established O by O Shanghai O Science O and O Technology O Commission O grant O number O 16DZ2281200 B-AWARD and O the B-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG grant O number O CARS-48 B-AWARD This O work O was O supported O by O the10.13039/501100000265United O Kingdom I-ORG Medical I-ORG Research I-ORG Council[grant O number O MR/N013638/1 B-AWARD and O the10.13039/100010663European O Research I-ORG Council I-ORG under I-ORG the I-ORG European I-ORG Union's I-ORG Seventh I-ORG Framework I-ORG Programme[FP7/2007–2013/ERC O grant O agreement O number O 668954 B-AWARD The O Centre O for O Global O NCDs O is O supported O by O the10.13039/100004440Wellcome O Trust I-ORG Institutional I-ORG Strategic I-ORG Support I-ORG Fund[097834/Z/11/B O This O research O was O partly O supported O by O JST-PRESTO B-ORG JST-CREST I-ORG Grant O Nos O JPMJCR1524 B-AWARD JPMJCR15Q5 O and O JPMJCR18T3 O Grants-in-Aid B-ORG for I-ORG Scientific I-ORG Research I-ORG Grant O Nos O 25220910 B-AWARD 25707030 O 15H05882 O 15H05883 O 16H02209 O and O 17H01052 O the O Center O for O Spintronics O Research O Network O CSRN O and O Collaborative O Research O Center O on O Energy O Materials O E-IMR O The O work O at O IQM O was O supported O by O the O US B-ORG Department I-ORG of I-ORG Energy I-ORG office I-ORG of I-ORG Basic I-ORG Energy I-ORG Sciences I-ORG Division I-ORG of I-ORG Materials I-ORG Sciences I-ORG and I-ORG Engineering I-ORG under O grant O DE-SC0019331 B-AWARD This O study O was O funded O by O the O Malaria O in O Pregnancy O Consortium O through O a O grant O from O the O Bill B-ORG I-ORG Melinda I-ORG Gates I-ORG Foundation I-ORG 46099 O the O Pregvax O Consortium O through O a O grant O from O the O European B-ORG Union’s I-ORG Seventh I-ORG Framework I-ORG Programme I-ORG FP7-2007-HEALTH I-ORG PREGVAX O 201588 O and O the O Spanish B-ORG Government I-ORG EUROSALUD O 2008 I-AWARD Programme O and O Pfizer O Inc O through O an O investigator-initiated O research O grant O WS394663 O LR O was O supported O by O an O NHMRC O Early O Career O Fellowship O #1016443 O The O funders O had O no O role O in O study O design O data O collection O and O analyses O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O numbers O 31600580 B-AWARD and O 31971720 B-AWARD the O Research O Fund O for O Advanced O Talents O of O Northwest O A&F O University O grant O numbers O Z111021501 O Talent B-ORG Support I-ORG of I-ORG Shaanxi I-ORG Province O grant O numbers O A279021715 B-AWARD and O A279021830 B-AWARD and O Open O Research O Fund O of O Qinling O National O Forest O Ecosystem O Research O Station O grant O numbers O K3180218026 B-AWARD the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities O grant O numbers O 2452019175 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG to O K.Q O No.81670775 O the O Nutricia B-ORG Research I-ORG Foundation I-ORG The O Netherlands O grants O 2014-07 B-AWARD 2015-E2 I-AWARD to O K.Q O the O Research B-ORG Funds I-ORG of I-ORG Profession I-ORG Quota I-ORG Budget I-ORG from I-ORG Beijing I-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG 2017-bjsekyjs O to O K.Q O and O Funds B-ORG for I-ORG High-Level I-ORG Technical I-ORG Talents I-ORG in I-ORG the I-ORG Beijing I-ORG Health I-ORG System I-ORG Discipline O Backbone I-AWARD 2009-3-40 I-AWARD to O K.Q O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 61471223 B-AWARD 61601263 B-AWARD the O Shandong B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG Nos O 2014GSF118030 B-AWARD 2015GSF118179 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG No. O ZR2015FQ016 B-AWARD This O study O was O funded O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81500275 O and O 81672781 O Guangdong B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2016A030313080 O and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 21616323 O The O funding O body O provided O financial O support O only O no O participation O in O the O design O of O the O study O collection O analysis O or O interpretation O of O data O nor O in O writing O the O manuscript O National B-ORG Grant I-ORG Program I-ORG on I-ORG Key I-ORG Infectious I-ORG Disease I-ORG 2018ZX10301-101 O to O J.-H.W O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 81572001 O 81873965 B-AWARD NSFC-NIH B-ORG joint O grant O 81561128009 O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG CAS O QYZDB-SSW-SMC059 O Instrument B-ORG Developing I-ORG Project I-ORG of I-ORG CAS I-ORG YZ201649 O NSFC O 31800152 O to O W.-W.S O Funding O for O open O access O charge O National O Grant O Program O on O Key O Infectious O Disease O 2018ZX10301-101 O Natural O Science O Foundation O of O China O NSFC O 81572001 O 81873965 O NSFC-NIH O joint O grant O 81561128009 O Chinese O Academy O of O Sciences O CAS O QYZDB-SSW-SMC059 O Instrument O Developing O Project O of O CAS O YZ201649 O NSFC O 31800152 O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 32272937 B-AWARD the B-ORG special I-ORG funds I-ORG for I-ORG the I-ORG Efficient I-ORG Ecological I-ORG Agriculture I-ORG Innovation I-ORG Project I-ORG of I-ORG the I-ORG Taishan I-ORG Industry I-ORG Leading I-ORG Talent I-ORG Program I-ORG No. O LJNY202003 B-AWARD and O the B-ORG earmarked I-ORG fund I-ORG for I-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-44 O This O research O was O supported O by O the O Volkswagen B-ORG Foundation I-ORG project O number O 84816 B-AWARD the O Seventh B-ORG Framework I-ORG Programme I-ORG IRSES O of O the O European O Commission O CINAR-PATHOBACTER O 247658 O the O European B-ORG Cooperation I-ORG in I-ORG Science I-ORG and I-ORG Technology I-ORG BMBS B-AWARD COST I-AWARD Action I-AWARD BM1102 O and O by O the O Ministero B-ORG dell'Istruzione I-ORG dell'Università I-ORG e I-ORG della I-ORG Ricerca I-ORG project O protocol O 2012A4F828 B-AWARD 002 O The O article O processing O charge O was O funded O by O the O German O Research O Foundation O DFG O and O the O Albert O Ludwigs O University O Freiburg O in O the O funding O programme O Open O Access O Publishing O The O current O study O was O supported O by O grants O from O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG China I-ORG 2016YFC1304902 O the B-ORG Outstanding I-ORG Academic I-ORG Leaders I-ORG of I-ORG Shanghai I-ORG Health I-ORG System I-ORG program I-ORG 2017BR008 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81974118,81800702 O and O Shanghai B-ORG Municipal I-ORG Education I-ORG Commission–Gaofeng I-ORG Clinical I-ORG Medicine I-ORG Grant I-ORG Support I-ORG 20152527 O This O research O was O funded O by O Sichuan B-ORG Sex I-ORG Sociology I-ORG and I-ORG Sex I-ORG Education I-ORG Research I-ORG Centre I-ORG SXJYB1905 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 4045F41120040 O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2022C03038 O and O Hangzhou B-ORG Municipal I-ORG Health I-ORG Commission I-ORG 2021WJCY130 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC:31672106 O Zhongyuan B-ORG Science I-ORG Technology I-ORG Innovation I-ORG Leaders I-ORG 194200510007 O and O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD1000105 O The O funding O bodies O had O no O role O in O the O design O of O the O study O collection O analysis O or O interpretation O of O data O or O in O writing O the O manuscript O This O research O was O funded O by O the O Shan B-ORG Dong I-ORG Province I-ORG Nature I-ORG Science I-ORG Foundation I-ORG under O grant O ZR2022MF283 B-AWARD Discipline O with O Strong O Characteristics O of O Liaocheng B-ORG University-Intelligent I-ORG Science I-ORG and I-ORG Technology I-ORG under O Grant O 31946220821B0849 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O 62071496 B-AWARD This O work O was O supported O by O FONDECYT B-ORG 113.0256 O VRID_UDEC B-ORG 216.037.021-1.0 O and O Comisión B-ORG Nacional I-ORG de I-ORG Investigación I-ORG Científica I-ORG y I-ORG Tecnológica I-ORG CONICYT O 63130071 O Beca O Doctoral O to O AVS O The O research O reported O in O this O publication O was O supported O by O the O National B-ORG Institute I-ORG of I-ORG Nursing I-ORG Research I-ORG NINR O of O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH O under O Award O Number O F31NR013102 B-AWARD The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O National O Institutes O of O Health O This O work O was O also O supported O by O the O NIH/NINR O T32NR007077 B-AWARD the O University O of O California O Los O Angeles O UCLA O National B-ORG Institute I-ORG for I-ORG Occupational I-ORG Safety I-ORG and I-ORG Health I-ORG NIOSH O 2 B-AWARD T42 I-AWARD OH I-AWARD 8412-8 O the O UCLA O Institute O of O American O Cultures O IAC O and O the O 2011–2013 O Navajo O Nation O This O work O was O supported O by O grants O from O the B-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG of I-ORG Suzhou I-ORG No. O SYS201612 B-AWARD No. O SYS201749 B-AWARD the B-ORG Jiangsu I-ORG Provincial I-ORG Medical I-ORG Youth I-ORG Talent I-ORG No. O QNRC2016746 B-AWARD the B-ORG Societal I-ORG and I-ORG Developmental I-ORG Project I-ORG of I-ORG Suzhou I-ORG No. O SS201630 B-AWARD the B-ORG Suzhou I-ORG Key I-ORG Laboratory I-ORG for I-ORG Respiratory I-ORG Medicine I-ORG No. O SZS201617 B-AWARD the B-ORG Clinical I-ORG Medical I-ORG Center I-ORG of I-ORG Suzhou I-ORG No. O Szzx201502 B-AWARD the B-ORG Jiangsu I-ORG Provincial I-ORG Key I-ORG Medical I-ORG Discipline I-ORG No. O ZDXKB2016007 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81802885 B-AWARD No. O 81702870 B-AWARD the B-ORG Foundation I-ORG of I-ORG Health I-ORG Care I-ORG Rejuvenation I-ORG by I-ORG Science I-ORG and I-ORG Education I-ORG No. O KJXW2016003 B-AWARD and O the O Clinical O Key O Specialty O Project O of O China O This O research O was O funded O by O São B-ORG Paulo I-ORG State I-ORG Research I-ORG Support I-ORG Foundation I-ORG FAPESP O grant O number O 2018/23898-6 B-AWARD the O National B-ORG Council I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Development I-ORG CNPq O grant O number O 427602/2018-10 B-AWARD and O Coordination B-ORG for I-ORG the I-ORG Improvement I-ORG of I-ORG Higher I-ORG Education I-ORG Personnel I-ORG CAPES I-ORG scholarship I-ORG to O I.F O grant O number O 88887.185627/2018-00 B-AWARD This O study O was O supported O by O the O Taishan B-ORG Scholar I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG No. O tsqn201812159 B-AWARD the B-ORG Foundation I-ORG of I-ORG Clinical I-ORG Pharmacy I-ORG of I-ORG Chinese I-ORG Medical I-ORG Association I-ORG No. O LCYX-M008 B-AWARD and O Excellent B-ORG Youth I-ORG Foundation I-ORG Program I-ORG for I-ORG Developing I-ORG Health I-ORG by I-ORG Relying I-ORG on I-ORG Science I-ORG and I-ORG Education I-ORG of I-ORG Lianyungang I-ORG No. O QN1601 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O M.L O gratefully O acknowledges O the O support O of O the O Templeton B-ORG World I-ORG Charity I-ORG Foundation I-ORG grant O TWCF0606 B-AWARD and O the O John B-ORG Templeton I-ORG Foundation I-ORG grant O 62212 B-AWARD J.B O gratefully O acknowledges O the O support O of O the O National B-ORG Science I-ORG Foundation I-ORG NAIRI O award O 2020247 B-AWARD DMREF O award O 2118988 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31860123 O 31560153 B-AWARD Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDA26010101 O the O Second B-ORG Tibetan I-ORG Plateau I-ORG Scientific I-ORG Expedition I-ORG and I-ORG Research I-ORG STEP I-ORG program I-ORG 2019QZKK0301 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O by O the O National B-ORG Science I-ORG Fund I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG grant O no. O 81525023 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 81903373 B-AWARD the O National O Science O and O Technology O Major O Project O of O China O grant O no. O 2017ZX10103009–005 O and O the O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG NIHR O grant O no. O 16/137/109 B-AWARD using O UK O aid O from O the O UK O Government O to O support O global O health O research O The O views O expressed O in O this O publication O are O those O of O the O author(s O and O not O necessarily O those O of O the O NIHR O or O the O UK O Department O of O Health O and O Social O Care O Aase B-ORG og I-ORG Ejnar I-ORG Danielsens I-ORG Fond O 10-000145 B-AWARD The B-ORG Danish I-ORG Heart I-ORG Foundation O 08-10-R68-A2189-B999-22496 B-AWARD The B-ORG Lundbeck I-ORG Foundation O R118-2012-11710 B-AWARD This O research O was O funded O by O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG in I-ORG Taiwan I-ORG under O grant O MOST B-AWARD 111-2221-E-038-008 I-AWARD and O Taipei B-ORG Medical I-ORG University I-ORG Hospital I-ORG under O grant O 110IIT02 B-AWARD This O research O was O also O supported O by O the O University B-ORG System I-ORG of I-ORG Taipei I-ORG Joint I-ORG Research I-ORG Program I-ORG under O grant O 105TMU-TMUH-14 B-AWARD The O author O is O indebted O to O ONR B-ORG Departmental I-ORG Research I-ORG Initiative I-ORG ‘Sea O State O and O Boundary O Layer O Physics O of O the O Emerging O Arctic O Ocean’ O award O no. O N00014-131-0279 B-AWARD EU B-ORG FP7 I-ORG grant O no. O SPA-2013.1.1-06 O and O the O University O of O Otago O for O their O support O This O work O was O supported O by O EPSRC B-ORG grant O no. O EP/K032208/1 B-AWARD This O work O was O supported O by: O DEB-1242241 B-AWARD DEB-1242260 B-AWARD Dimensions B-ORG of I-ORG Biodiversity I-ORG DEB-1136626 B-AWARD DEB-1146440 B-AWARD Graduate B-ORG Research I-ORG Fellowships I-ORG DGE-0903734 B-AWARD and O DGE-1452154 B-AWARD and O Partnerships B-ORG for I-ORG International I-ORG Research I-ORG and I-ORG Education I-ORG PIRE O OISE B-AWARD 0730218 I-AWARD from O the O U.S B-ORG National I-ORG Science I-ORG Foundation I-ORG CICESE I-ORG internal O project O O0F092 B-AWARD SAGARPA-FIRCO B-ORG grant O RGA-BCS-12-000003 B-AWARD UCMEXUS B-ORG grant O CN-13-617 B-AWARD and O CB-CONACYT B-ORG grants O 106925 B-AWARD and O 157993 B-AWARD There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81670777 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. O LY18H310010 O the O Natural O Science O Foundation O of O Zhejiang O Province O No. O LZ19H020001 O and O Key B-ORG Medical I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. O WKJ-ZJ-1625 O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81703871 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province I-ORG 2020-MS-265 O and O the O Scientific B-ORG Research I-ORG Fund I-ORG of I-ORG Liaoning I-ORG Provincial I-ORG Education I-ORG Department I-ORG LZ2019045 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O grants O from O the O Bill B-ORG and I-ORG Melinda I-ORG Gates I-ORG Foundation I-ORG to O Syed O Asad O Ali O OPP1138727 B-AWARD and O Sean O Moore O OPP1144149 B-AWARD Fogarty B-ORG International I-ORG Center I-ORG of I-ORG the I-ORG National I-ORG Institutes I-ORG of I-ORG Health I-ORG grants O no. O K43TW010697 B-AWARD NTI O and O D43TW007585 B-AWARD SAA O SRM O and O by O the O National B-ORG Institute I-ORG of I-ORG Diabetes I-ORG and I-ORG Digestive I-ORG and I-ORG Kidney I-ORG Diseases I-ORG NIDDK O of O the O National O Institutes O of O Health O under O award O number O K23DK117061 B-AWARD SS O This O study O was O supported O by O the O National B-ORG Key I-ORG Project I-ORG of I-ORG Water I-ORG Pollution I-ORG Control I-ORG and I-ORG Management I-ORG No. O 2012ZX07313001 O Shaanxi B-ORG Science I-ORG I-ORG Technology I-ORG Co-ordination I-ORG I-ORG Innovation I-ORG Project I-ORG 2016TZC-S-19-3 O and O the O Program B-ORG for I-ORG Innovative I-ORG Research I-ORG Team I-ORG in I-ORG Shaanxi I-ORG Province I-ORG PIRT O No. O 2013KCT-13 O The O Quinact O trial O was O co-funded O by O Fonds B-ORG Wetenschappelijk I-ORG Onderzoek I-ORG FWO O Grant O reference O G.078.11 B-AWARD to O JPVg O Vlaamse B-ORG Interuniversitaire I-ORG Raad-Universitaire O Ontwikkelings O Samenwerking O VLIR-UOS O Grant O reference O ZRDC2012MP076 B-AWARD to O JPVg O PL O European B-ORG and I-ORG Developing I-ORG Countries I-ORG Clinical I-ORG Trials I-ORG Partnership I-ORG EDCTP O Grant O reference O MS.2010.10800.004 B-AWARD to O JPVg O and O the O Belgian B-ORG Technical I-ORG Cooperation-Programme I-ORG d’Etudes I-ORG et I-ORG d’Expertises-in I-ORG the I-ORG Democratic I-ORG Republic I-ORG of I-ORG Congo I-ORG BTC O Grant O reference O FEE/06/12 B-AWARD to O PL O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Shanghai B-ORG Jiao I-ORG Tong I-ORG University I-ORG Yi I-ORG Gong I-ORG Jiao I-ORG Cha I-ORG Funding I-ORG YG2016MS74 O to O Qifeng O Li O Shanghai B-ORG Shen I-ORG Kang I-ORG Hospital I-ORG Development I-ORG Center I-ORG Funding I-ORG 16CR2031B O to O Jie O Ma O Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Committee I-ORG Funding I-ORG 17411951800 O to O Jie O Ma O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81572761 O and I-AWARD 81772655 I-AWARD to O Yujie O Tang O 81500601 B-AWARD to O Chenran O Zhang O and O 81702453 B-AWARD to O Yang O Zhao O This O work O was O funded O by O research O grants O from O the O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG Sex O differences O Catalyst O grant O SVB B-AWARD 145590 I-AWARD to O N.S O N.P O and O Cystic B-ORG Fibrosis I-ORG Canada I-ORG Discovery O grants O 3180 B-AWARD N.P O and O 3029 B-AWARD to O N.S O and O N.P O M.A.K O is O a O recipient O of O Mitacs B-ORG Accelerate B-AWARD postdoctoral I-AWARD fellowship I-AWARD and O Cystic O Fibrosis O Canada O matching O funds O 3180 O to O NP O WCC O is O currently O receiving O a O Grant O TTCRD-104-07 O from O Taichung B-ORG Tzuchi I-ORG Hospital O CCT O is O currently O receiving O Grants O DMR-104-014 O MOHW105-TDU-B-212-133019 B-AWARD from O China B-ORG Medical I-ORG University I-ORG Hospital O and O Taiwan O Ministry B-ORG of I-ORG Health I-ORG and I-ORG Welfare I-ORG Clinical O Trial O and O Research O Center O of O Excellence O For O the O remaining O authors O none O were O declared O This O work O was O supported O by O grants O from O the O Research B-ORG Project I-ORG of I-ORG Fudan I-ORG University I-ORG Shanghai I-ORG Cancer I-ORG Center I-ORG YJ201401 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81572583 O 81502278 I-AWARD 81372848 I-AWARD 81370075 O the B-ORG Municipal I-ORG Project I-ORG for I-ORG Developing I-ORG Emerging I-ORG and I-ORG Frontier I-ORG Technology I-ORG in I-ORG Shanghai I-ORG Hospitals I-ORG SHDC12010116 O the B-ORG Cooperation I-ORG Project I-ORG of I-ORG Conquering I-ORG Major I-ORG Diseases I-ORG in I-ORG Shanghai I-ORG Municipality I-ORG Health I-ORG System I-ORG 2013ZYJB0302 O the B-ORG Innovation I-ORG Team I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG IRT1223 O and O the B-ORG Shanghai I-ORG Key I-ORG Laboratory I-ORG of I-ORG Breast I-ORG Cancer O 12DZ2260100 O The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81860355 O 2015 O Ningxia B-ORG Scientific I-ORG and I-ORG technological I-ORG innovation I-ORG leader I-ORG training I-ORG project I-ORG KJT2015020 O First-class B-ORG Discipline I-ORG construction I-ORG of I-ORG clinical I-ORG medicine I-ORG of I-ORG Ningxia I-ORG Medical I-ORG University I-ORG NXYLXUK2017A05 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Ningxia I-ORG Province I-ORG of I-ORG China I-ORG 2018AAC03088 O This O research O was O funded O in O part O by O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Taiwan I-ORG Government I-ORG MOST-105-2314-B-038 O 034 I-AWARD MY3 O Shin B-ORG Kong I-ORG Wu I-ORG Ho-Su I-ORG Memorial I-ORG Hospital I-ORG SKH-8302-105-DR-12 O and O Taipei B-ORG Medical I-ORG University I-ORG SKH-TMU-100-03 O This O work O was O supported O by O Japan B-ORG Science I-ORG and I-ORG Technology I-ORG Agency I-ORG Advanced O Integrated O Intelligence O Public/Private O R&D O Investment O Strategic O Expansion O Program O JPMJCR18Y3 O Ministry B-ORG of I-ORG Education I-ORG Culture I-ORG Sports I-ORG Science I-ORG and I-ORG Technology/Japan O Society O for O the O Promotion O of O Science O KAKENHI O 17H06410 O to O Y.S O 19K20409 O to O Y.S O 19K06502 O to O Y.S O 19K06077 O to O Y.S O and O Japan B-ORG Agency I-ORG for I-ORG Medical I-ORG Research I-ORG and I-ORG Development I-ORG JP19ak0101122 O to O Y.S O JP19am0401023 O to O Y.S O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21476212 O Science B-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2018C02038 O and O Bureau B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Zhoushan I-ORG 2017C41005 O This O work O was O jointly O funded O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC0407200 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M640499 O and O the O research O project O from O Nanjing B-ORG Hydraulic I-ORG Research I-ORG Institute I-ORG Y118009 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Projects O 51473164 B-AWARD and O 51673186 B-AWARD the O joint O funded O program O of O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG and I-ORG Japan I-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG GJHZ1519 O and O the O Special B-ORG Fund I-ORG for I-ORG Industrialization I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Cooperation I-ORG between I-ORG Jilin I-ORG Province I-ORG and I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG 2017SYHZ0021 O This O work O was O supported O by O the O PhD O Start-up O Fund B-ORG of I-ORG Guangdong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG NO.2016A030310329 O the B-ORG Special I-ORG Program I-ORG for I-ORG Outstanding I-ORG Young I-ORG Teachers I-ORG of I-ORG Guangdong I-ORG Ocean I-ORG University I-ORG NO.HDYQ2017002 O the B-ORG Program I-ORG for I-ORG Scientific I-ORG Research I-ORG Start-up I-ORG Funds I-ORG of I-ORG Guangdong I-ORG Ocean I-ORG University I-ORG NO.R17040 O and O the O Fund O of O Guangdong O Provincial O Natural O Science O Foundation O NO.2016A030313752 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32271584 O 32071520 B-AWARD and O 31600445 B-AWARD the O Natural B-ORG Science I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG Shaanxi I-ORG 2020JM-286 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG GK202103072 O College B-ORG Students’ I-ORG Innovative I-ORG Entrepreneurial I-ORG Training I-ORG Plan I-ORG Program I-ORG 202210718052 O This O work O was O supported O by O the O Korea B-ORG Healthcare I-ORG Technology I-ORG Research I-ORG I-ORG Development I-ORG Project I-ORG Ministry I-ORG of I-ORG Health I-ORG and I-ORG Welfare I-ORG Republic I-ORG of I-ORG Korea I-ORG HR16C0002 O and O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O grants O 2017R1A6A3A04008889 O and O 2021R1C1C1013187 B-AWARD and O the O R&BD B-ORG Program I-ORG through I-ORG the I-ORG INNOPOLIS I-ORG funded I-ORG by I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG ICT I-ORG 2022-IT-RD-0397 O This O work O was O financially O supported O by O the O Centers O of O Genomic O and O Precision O Medicine O National O Taiwan O University O Taipei O Taiwan O This O study O was O also O supported O by O the O following O research O grants O NTU-107L9014 B-ORG NTU-108L901403 O from O Ministry O of O Education O Taiwan O MOST O 106-2314-B-002-229-MY3 B-AWARD MOST O 107-3017-F-002-002 B-AWARD MOST O 107-2314-B-002 B-AWARD 210 I-AWARD MY3 O 108-2314-B-002 B-AWARD 075 I-AWARD MY3 O MOST O 108-3017-F-002-004 B-AWARD from O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology O Taiwan O YongLin O Chair O Grant O S-01 O from O National O Taiwan O University O NTUH-107-S3837 B-AWARD and O NTUH-108-010 B-AWARD from O National B-ORG Taiwan I-ORG University I-ORG Hospital O This O research O was O supported O by O the O Rare B-ORG Tumor I-ORG Research I-ORG Special I-ORG Project I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82141104 O the O National O Natural O Science O Foundation O of O China O U21A20374 O and O 82141129 B-AWARD the O Shanghai B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG 21JC1401500 O the O Scientific B-ORG Innovation I-ORG Project I-ORG of I-ORG Shanghai I-ORG Education I-ORG Committee I-ORG 2019-01-07-00-07-E00057 O the O Clinical B-ORG Research I-ORG Plan I-ORG of I-ORG Shanghai I-ORG Hospital I-ORG Development I-ORG Center I-ORG SHDC2020CR1006A O and O the O Xuhui B-ORG District I-ORG Artificial I-ORG Intelligence I-ORG Medical I-ORG Hospital I-ORG Cooperation I-ORG Project I-ORG 2021-011 O This O research O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province O China O No. O 2015CFA091 B-AWARD XH O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Program O No. O 2015PY181 B-AWARD XH O No. O 2662017PY104(XH B-AWARD and O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0501500 B-AWARD XH I-AWARD Huiping O Zhou O is O a O VA B-ORG Research I-ORG Career I-ORG Scientist I-ORG IK6BX004477 O this O work O was O supported O by O a O VA B-ORG Merit I-ORG Award I-ORG I01BX004033 B-AWARD VA B-ORG ShEEP I-ORG grants I-ORG 1IS1BX005517-01 O and O 1IS1BX004777-01 B-AWARD and O National B-ORG Institutes I-ORG of I-ORG Health I-ORG Grants I-ORG R01 B-AWARD DK104893 O R01DK-057543 B-AWARD and O R21 B-AWARD AA026629-01 I-AWARD This O study O was O supported O by O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico—CNPq O Proc O nos O 401962/2016-4 B-AWARD and O 304992/2015-1 B-AWARD Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo O FAPESP O Proc O No O 2016/22196-2 B-AWARD and O CAPES/Alexander O von O Humboldt O Proc O No. O 88881.136128/2017-01 O Further O by O the O project B-ORG EXCELLENCE I-ORG CZ.02.1.01/0.0/0.0/15_003/0000460 B-AWARD OP O RDE O and O with O the O institutional O support O RVO O 67985904 O PR O S.R.M O received O fellowship O from O FAPESP O 2017/16328-6 O This O study O has O been O financed O partially O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U1505251 O 71532014 B-AWARD the O National B-ORG Key I-ORG Technology I-ORG R&D I-ORG Program I-ORG 2015BAI06B02 O the O STS B-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG KFZD-SW-202 O KFJ-SW-STS-161 B-AWARD the O Guangdong B-ORG Innovation I-ORG Research I-ORG Team I-ORG Funds I-ORG for I-ORG Image-Guided I-ORG Therapy I-ORG 2011S013 O Key B-ORG Program I-ORG for I-ORG the I-ORG Guangdong I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Fund I-ORG 2015B020233011 O 2014B010111008 B-AWARD the O Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Fund I-ORG JCYJ20160229200556939 O the O Technology B-ORG Innovation I-ORG Fund I-ORG of I-ORG Shenzhen I-ORG Peacock I-ORG Talent I-ORG KQJSCX2016030114125686 O and O Nanshan B-ORG District I-ORG Project I-ORG of I-ORG Shenzhen I-ORG KC2015JSJS0014A O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0200400 O the B-ORG National I-ORG Basic I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2013CB127604 O and O the B-ORG Postgraduate I-ORG Practical I-ORG Innovation I-ORG Project I-ORG of I-ORG Yangzhou I-ORG University I-ORG XSJCX18_068 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31601899 O 31670414 I-AWARD and I-AWARD 31470477 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG 2016J01104 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017M612111 O 2018T110635 O State O Key O Laboratory O of O Ecological O Pest O Control O for O Fujian O and O Taiwan O Crops O Fujian O Provincial O Excellent O Youth O Science O Foundation O 2017J06010 O Central O Guidance O on O the O Development O of O Local O Science O and O Technology O Fujian O 2017L3003 O and O Fujian-Taiwan O Joint O Innovative O Center O for O Germplasm O Resources O and O cultivation O of O crop O FJ2011 O Program O NO. O 2015-75 O China O This O work O was O partially O supported O by O a O compensatory O measure O established O by O the O Term O of O Adjustment O of O Conduct O of O responsibility O of O PetroRio O conducted O by O the O Ministério O Público O Federal-MPF/RJ O with O the O implementation O of O the O Fundo O Brasileiro O para O a O Biodiversidade—FUNBIO O Grant O 16/2017 O to O FGA O and O partially O supported O by O the O Strategic O Funding O UID/Multi B-AWARD 04423/2019 I-AWARD through O national O funds O provided O by O FCT B-ORG and I-ORG European I-ORG Regional I-ORG Development I-ORG Fund I-ORG ERDF O in O the O framework O of O the O program O PT2020 O This O research O was O conducted O under O SISBIO O Collection O of O Species O Permit O number O 10707 O issued O by O ICMBio O Brazilian O Environmental O Agency O Grants O for O TPF O were O provided O by O the O Fundação O Carlos O Chagas O Filho O de O Amparo O à O Pesquisa O do O Estado O do O Rio O de O Janeiro—FAPERJ O PDR10 O E-26/202.301/2018 I-AWARD and O E-26/202.302/2018 B-AWARD This O work O was O supported O by O grants O from O the O US B-ORG National I-ORG Institutes I-ORG of I-ORG Health I-ORG https://www.nih.gov O HL070041 B-AWARD and O US B-ORG American I-ORG Heart I-ORG Association I-ORG http://www.heart.org/HEARTORG O 13GRNT16810043 B-AWARD to O MK O and O JSPS B-ORG KAKENHI I-ORG https://www.jsps.go.jp/english/index.html O Grant O Number O 22227005 B-AWARD to O SIshiwata O and O by O The B-ORG Japan I-ORG Science I-ORG and I-ORG Technology I-ORG Agency I-ORG http://www.jst.go.jp/EN O Grant O Number O JPMJPR15F5 B-AWARD to O MS O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O co-funded O by O the O Swiss-African O Research O Cooperation O SARECO O Samuel O Fuhrimann’s O effort O was O supported O by O two O professorial O fellowships O of O the O Swiss B-ORG National I-ORG Science I-ORG Foundation I-ORG SNSF O grant O numbers O TMSGI3_211325 B-AWARD Daniel O Marcu’s O effort O was O funded O by O the O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG BBSRC)—Doctoral O Training O Partnership O grant O numbers O 100275665RA1 B-AWARD Liana O Maree’s O effort O was O funded O by O Senate B-ORG Research I-ORG Funding I-ORG Department I-ORG of I-ORG Research I-ORG Development I-ORG University I-ORG of I-ORG the I-ORG Western I-ORG Cape I-ORG AR20/10/2 O Leslie O Petrik’s O effort O was O funded O by O the O Meerwissen B-ORG project I-ORG African I-ORG penguins I-ORG and I-ORG blue I-ORG economy I-ORG Building I-ORG a I-ORG foundation I-ORG to I-ORG prevent I-ORG extinction I-ORG project O processing O number O 19.2036.2-002.00 B-AWARD contract O number O 81255032 B-AWARD The O research O was O supported O by O the O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG CN) O 31671646 O Guangxi B-ORG innovation-driven I-ORG development I-ORG special I-ORG funding I-ORG project I-ORG Guike-AA17204070 O High B-ORG Level I-ORG Innovation I-ORG Team I-ORG and I-ORG Outstanding I-ORG Scholar I-ORG in I-ORG Guangxi I-ORG Colleges I-ORG and I-ORG Universities I-ORG 2016 O and O Guangxi B-ORG Hundred-Talents I-ORG Program I-ORG 2015 O The O funding O body O had O no O role O in O study O design O data O collection O analyses O and O interpretation O decision O to O publish O or O preparation O of O manuscript O This O work O was O supported O by O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81671379 B-AWARD 81670226 O Guangdong B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Foundation I-ORG Nos O 2017A020215085 B-AWARD 2017A020215130 B-AWARD Guangdong B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No: O 2018A030313807 B-AWARD and O Shenzhen B-ORG Natural I-ORG Science I-ORG Foundation I-ORG JCYJ20180306180229307 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Contract O grant O number O 81671126 B-AWARD and O 81730048 B-AWARD to O X.L O 81471390 B-AWARD to O N.M O 81371290 B-AWARD to O Z.R.M O Beijing B-ORG High-level I-ORG Personnel I-ORG Funds I-ORG Contract O grant O number O 2013-2-19 B-AWARD to O Z.R.M O and O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Contract O grant O number O 2016YFC0100100 B-AWARD to O X.L O Medical B-ORG and I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Zhejiang I-ORG Province I-ORG Contract O grant O number O 2015KYA080 B-AWARD to O Z.Q.X O This O work O was O supported O by O the O National B-ORG Special I-ORG Foundation I-ORG for I-ORG Transgenic I-ORG Species I-ORG of I-ORG China I-ORG 2014ZX0800950B-003 O to O Yiqiang O Zhao O Whole B-ORG Genome I-ORG Analysis I-ORG and I-ORG Introduction I-ORG of I-ORG Important I-ORG Functional I-ORG Genes I-ORG in I-ORG Animals I-ORG 948 O Program O 2012-G1 O 4)) O to O Xiaoxiang O Hu, O and O the O National B-ORG Program I-ORG on I-ORG the I-ORG Key I-ORG Basic I-ORG Research I-ORG Project I-ORG 973 O Program O 2014CB138501 O to O Ran O Zhang O This O research O was O funded O by O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG 973 I-ORG program I-ORG in I-ORG China I-ORG No.2014CB138705 O the B-ORG earmarked I-ORG fund I-ORG for I-ORG Modern I-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG No. O CARS-34 O and O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 31872997 O The O funding O bodies O had O no O role O in O study O design O data O collection O analysis O and O interpretation O decision O to O public O or O manuscript O preparation O The O research O was O supported O by O the O Hainan B-ORG Provincial I-ORG Joint I-ORG Project I-ORG of I-ORG Sanya I-ORG Yazhou I-ORG Bay I-ORG Science I-ORG and I-ORG Technology I-ORG City I-ORG No. O 520LH016 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 52068061 B-AWARD and O the O Key B-ORG R&D I-ORG Program I-ORG of I-ORG Hubei I-ORG Province I-ORG No. O 20211G0098 B-AWARD This O study O was O supported O in O part O by O grants O from O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2022YFS0132 O Key B-ORG Research I-ORG Program I-ORG of I-ORG National I-ORG Clinical I-ORG Research I-ORG Center I-ORG for I-ORG Geriatrics I-ORG Z20191004 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81970715 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2021TQ0227 O and O Innovation B-ORG Spark I-ORG Project I-ORG of I-ORG Sichuan I-ORG University I-ORG 2018SCUH0065 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No: O 81571452 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG Grant O No: O 2017A030310191 B-AWARD and O Clinical B-ORG Medical I-ORG Project I-ORG 5010 I-ORG of I-ORG Sun I-ORG Yat-sen I-ORG University O China O Grant O No: O 2012004 B-AWARD This O work O was O supported O by O grants O from O the O Chinese B-ORG Ministry I-ORG of I-ORG Health I-ORG 2012ZX O 10001006 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31370182 O and O 81271812 B-AWARD and O 111 B-ORG Project I-ORG B08011 O This O research O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0300504 O 2017YFD0100501 B-AWARD LiaoNing B-ORG Revitalization I-ORG Talents I-ORG Program I-ORG XLYC1807233 O Program B-ORG for I-ORG Liaoning I-ORG Excellent I-ORG Talents I-ORG in I-ORG University I-ORG LR2017007 O This O research O was O funded O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG No. O 2019YFC1605800 B-AWARD Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BE2022370 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Higher I-ORG Education I-ORG Institutions I-ORG of I-ORG Jiangsu I-ORG Province O China O 20KJB240001 O This O work O was O supported O by O the O National B-ORG High-Tech I-ORG Research I-ORG and I-ORG Development I-ORG Programs I-ORG of I-ORG China I-ORG “863 O Program” O for O the O 12th O Five-Year O Plants O No. O 2013AA102902 B-AWARD Agro-scientific B-ORG Research I-ORG in O the O Public O Interest O under O Grant O 201303104 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31601256 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Number O 81672546 B-AWARD to O LZ; O 81772703 B-AWARD to O YG; O and O 81422035 B-AWARD and O 81672541 B-AWARD to O WC O the O Clinical B-ORG Features I-ORG Research I-ORG of I-ORG Capital I-ORG Z151100004015173 O to O LZ O the O Capital B-ORG Health I-ORG Research I-ORG and I-ORG Development I-ORG of I-ORG Special I-ORG 2016-1-4077 O to O LZ O CAS B-ORG Strategic I-ORG Priority I-ORG Research I-ORG Program I-ORG XDA16010102 O to O WC O and O the O National B-ORG Basic I-ORG Research I-ORG Programme I-ORG 2016YFC0900303 O to O WC O SAR O was O supported O by O grants O from O the O PAHO B-ORG ME/CNT/1500013.001 O and O the O Mexican B-ORG Government O Consejo O Nacional O de O Ciencia O y O Tecnología O CONACyT O SALUD-2013-01-202475 B-AWARD and O Comisión B-AWARD de I-AWARD Equidad I-AWARD y I-AWARD Género I-AWARD de I-AWARD las I-AWARD Legislaturas I-AWARD LX-LXI I-AWARD y I-AWARD Comisión I-AWARD de I-AWARD Igualdad I-AWARD de I-AWARD Género I-AWARD de I-AWARD la I-AWARD Legislatura I-AWARD LXII I-AWARD de I-AWARD la I-AWARD H. I-AWARD Cámara I-AWARD de I-AWARD Diputados I-AWARD de I-AWARD la I-AWARD República I-AWARD Mexicana I-AWARD This O research O was O funded O by O the O Ministry B-ORG of I-ORG Education I-ORG in I-ORG China I-ORG Project I-ORG of I-ORG Humanities I-ORG and I-ORG Social I-ORG Sciences I-ORG Grant O number O 21YJC890020 B-AWARD Chengdu B-ORG Normal I-ORG University I-ORG Teaching I-ORG Reform I-ORG Project I-ORG Grant O number O 2021JG49 B-AWARD Chengdu B-ORG Normal I-ORG University I-ORG Model I-ORG Course I-ORG Curriculum O Civics” O Grant O number O XJKCSZKC2023 B-AWARD Chengdu B-ORG Normal I-ORG University I-ORG Project I-ORG Grant O number O CS21SC03 B-AWARD Chengdu B-ORG World I-ORG Event I-ORG City I-ORG Research I-ORG Center I-ORG Grant O number O CDMC2022B05 B-AWARD Sichuan B-ORG Province I-ORG first-class I-ORG undergraduate I-ORG online I-ORG course I-ORG Teach O you O to O practice O good O temperament O O Yoga O Grant O number O 2022SJYLKC02 B-AWARD all O awarded O to O XL. O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 81430099 B-AWARD 31500704 B-AWARD and O 81904142 B-AWARD Projects B-ORG of I-ORG International I-ORG Cooperation I-ORG and I-ORG Exchanges I-ORG grant O number O 2014DFA32950 B-AWARD and O research O program O from O Beijing B-ORG University I-ORG of I-ORG Chinese I-ORG Medicine I-ORG grant O numbers O 1000041510049 B-AWARD BUCM-2019-JCRC006 B-AWARD and O 2019-JYB-TD013 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Stem O Cell O and O Translational O Research O 2016YFA0101202 B-AWARD NSFC B-ORG grant I-ORG 81530075 O and O 81472741 B-AWARD Fudan B-ORG University I-ORG Research I-ORG Foundation I-ORG IDH O 1340042 O Research B-ORG Foundation I-ORG of I-ORG the I-ORG Fudan I-ORG University I-ORG Shanghai I-ORG Cancer I-ORG Center I-ORG YJRC1603 O and O the B-ORG MOST I-ORG grant I-ORG 2015CB553800 O This O research O was O financially O supported O by O the O Program O for O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51674089 B-AWARD 51704076 B-AWARD Excellent B-ORG Youth I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG of I-ORG China I-ORG No. O JC2018002 B-AWARD and O the O Youth B-ORG Fund I-ORG of I-ORG Northeast I-ORG Petroleum I-ORG University I-ORG No. O 2018QNL-17 B-AWARD This O work O had O been O based O on O a O previously O published O meeting O abstract O IBRO O Reports O vol O 6, O Supplement O Pages O S249 O This O study O was O carried O out O with O the O support O of O Cooperative O Research O Program O for O Agriculture O Science O and O Technology O Development O Project O No.PJ01321101 O Rural B-ORG Development I-ORG Administration O Republic O of O Korea O and O supported O by O Korea O Institute O of O Planning O and O Evaluation O for O Technology O in O Food O Agriculture O and O Forestry O IPET O through O High O Value-added O Food O Technology O Development O Program O funded O by O Ministry B-ORG of I-ORG Agriculture I-ORG Food I-ORG and I-ORG Rural I-ORG Affairs I-ORG MAFRA O 117055-3 O and O supported O by O Basic O Science O Research O Program O through O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O funded O NRF-2017R1D1A1B03033271 O This O work O was O supported O by: O Medical B-ORG Research I-ORG Council I-ORG Doctoral I-ORG Training I-ORG Centre I-ORG scholarship I-ORG MR/K501281/1 O Imperial B-ORG College I-ORG scholarship I-ORG EP/M506345/1 O La O Caixa O studentship O to O A.R.M O a O Rutherford O Fund O Fellowship O at O Health B-ORG Data I-ORG Research I-ORG UK I-ORG MR/S004033/1 O to O J.M.P O European B-ORG Commission I-ORG FGENTCARD O LSHG-CT-2006-037683 B-AWARD to O D.G O and O J.K.N O NMR O experiments O were O run O in O the O Clinical O Phenome O Centre O which O is O supported O by O the O NIHR O Imperial O Biomedical O Research O Centre O based O at O Imperial O College O Healthcare O National O Health O Service O NHS O Trust O and O Imperial O College O London O The O views O expressed O are O those O of O the O author(s O and O not O necessarily O those O of O the O NHS O the O NIHR O or O the O Department O of O Health O This O work O was O supported O by O Boston O University O Horace O H. O Rackham O School O of O Graduate O Studies O University O of O Michigan O Leakey O Foundation O Nacey O Maggioncalda O Foundation O National B-ORG Geographic I-ORG Society O Grant O Number O 9824-15 B-AWARD National B-ORG Institute I-ORG on I-ORG Aging O Grant O Number O 5R01AG049395 B-AWARD National B-ORG Science I-ORG Foundation O Grant O Number O 0416125,0849380,1355014,1521528,9807448,BCS-1540259,BCS-1613393,DGE-1256260 B-AWARD University O of O New O Mexico O University O of O Wisconsin-Madison O John O D. O MacArthur O Fellowship O Program O Wenner-Gren O Foundation O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81771843 B-AWARD Science O and O Technology B-ORG Developing I-ORG Program I-ORG of I-ORG Shandong I-ORG Provincial I-ORG Government I-ORG of I-ORG China I-ORG No. O 2017GSF18107 B-AWARD and O the B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Planning I-ORG of I-ORG Jinan I-ORG City I-ORG in I-ORG Shandong I-ORG province I-ORG of I-ORG China I-ORG No. O 201704084 B-AWARD This O research O was O funded O by O The O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61771195 B-AWARD The O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG No. O F2018502047 B-AWARD The O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 2020MS098 B-AWARD This O research O was O partially O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31961133006 O the O National O Key O Research O and O Development O Program O of O China O 2017YFB0309302 O the O Shanghai B-ORG Pujiang I-ORG Program I-ORG 18PJD013 O and O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2011CB707406 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81790631 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC2000500 O the O National O Natural O Science O Foundation O of O China O 81570512 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG China I-ORG LQ19H030007 O The O funding O provides O research O expenditure O for O the O present O study O i.e O reagents O and O consumables O for O related O experiments O This O work O was O supported O by O the O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG of I-ORG the I-ORG Fujian I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG STIT O 2017-1-1 O the O National B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2016YFD0101801 O the O Special B-ORG Foundation I-ORG of I-ORG Non-Profit I-ORG Research I-ORG Institutes I-ORG of I-ORG Fujian I-ORG Province I-ORG 2018R1101013-4 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31521064 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality O Grant O Number:19ZR1430000 O Hospital B-ORG Innovation I-ORG Project O Grant O Number O CK2019004 B-AWARD Hospital B-ORG Cross-Multidisciplinary I-ORG Project O Grant O Number:JYJC201911 O This O research O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81670946 O and O Beijing B-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospitals I-ORG Clinical I-ORG Medicine I-ORG Development I-ORG of I-ORG Special I-ORG Funding I-ORG Support I-ORG code O XMLX201507 B-AWARD and O Beijing B-ORG Tongren I-ORG Hospital I-ORG Capital I-ORG Medical I-ORG University I-ORG scientific I-ORG research I-ORG backbone I-ORG fund I-ORG 2015-YJJ-GGL-002 O This O study O was O supported O by O grants O from O the O Guizhou B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Project I-ORG No. O 2021-General B-AWARD 415 O the O Guizhou B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2020-1Y404 O and O the O Guizhou B-ORG Provincial I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Training I-ORG Project I-ORG for I-ORG College I-ORG Students I-ORG No. O S202110660009 B-AWARD No. O S202210660145 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51802042 O 51832002 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017A030310570 O 2018A030313353 B-AWARD Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG 201904010357 O This O work O is O supported O by O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG program I-ORG of I-ORG Jiangsu I-ORG province I-ORG BE2016612 O Jiangsu B-ORG Provincial I-ORG Key I-ORG Medical I-ORG Center I-ORG YXZXB2016004 O and O the O Fundamental O Research O Funds O for O the O Central O University O from O Peking B-ORG Union I-ORG Medical I-ORG College I-ORG 3332018186 O The O first O and O second O authors O are O the O funding O receivers O whom O have O contributed O in O the O review O designing O and O manuscript O writing O This O work O was O supported O by O the O Key O Project O from O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG grant O number O 2018ZX09721003 B-AWARD Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG grant O number O 7171004 B-AWARD and O Scientific O Research O Incubation O Fund O of O Beijing O Children's O Hospital O Capital B-ORG Medical I-ORG University I-ORG grant O number O GPY201711 B-AWARD This O study O was O funded O by O the O National B-ORG Research I-ORG Foundation I-ORG NRF O A0Z631 O the O Research B-ORG Committee I-ORG School I-ORG of I-ORG Medicine I-ORG of I-ORG the I-ORG University I-ORG of I-ORG Pretoria I-ORG RESCOM O AD546 O the O Research B-ORG Development I-ORG Program I-ORG of I-ORG the I-ORG University I-ORG of I-ORG Pretoria I-ORG A0Z311 O and O the O South B-ORG African I-ORG Medical I-ORG Research I-ORG Council I-ORG A1A083 O This O study O was O supported O by O the B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 2009BAI77B08 O Shanghai B-ORG One I-ORG Hundred I-ORG Talent I-ORG Project I-ORG in I-ORG health I-ORG division I-ORG XBR2011015 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81371486 O These O experiments O were O supported O by O grants O from O Pearl B-ORG River I-ORG Nova I-ORG Program I-ORG of I-ORG Guangzhou I-ORG Grant O No. O 201710010030 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81572014 B-AWARD the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2015AA020934 B-AWARD National B-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG of I-ORG China I-ORG No. O 2016YFC1200500 B-AWARD grant O from O the O Doctoral B-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG of I-ORG China I-ORG Grant O No. O 20120171120049 B-AWARD and O grant O from O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG Grant O No. O S2012040007256 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 51675397 B-AWARD 11702202 O The O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG No. O 2018JZ5005 B-AWARD China B-ORG Scholarship I-ORG Council I-ORG No. O 201706965037 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O JB180414 B-AWARD The O 111 O Project O No. O B14042 B-AWARD This O study O was O supported O in O part O by O Taiwan’s B-ORG Ministry I-ORG of I-ORG Health I-ORG and I-ORG Welfare I-ORG Clinical I-ORG Trial I-ORG Center I-ORG MOHW110-TDU-B-212-124004 O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG MOST O 110-2321-B-039-003 O and O China B-ORG Medical I-ORG University I-ORG Hospital I-ORG DMR-111-228 O The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O the O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81621064 O and O 81361138020 B-AWARD Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 7172136 O and O the B-ORG CAMS I-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG 2017-12M-1-012 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O No. O 81471209 B-AWARD 81641055 B-AWARD 81000504 B-AWARD to O XL O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG grant O No. O 7132112 B-AWARD to O XL O and O Distinguished B-ORG Professor I-ORG of I-ORG Cheung I-ORG Kong I-ORG Scholars I-ORG Program I-ORG grant O No. O T2014251 B-AWARD to O XJ O This O research O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG grant O number O LQ23H280016 B-AWARD Key B-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG grant O number O 2017C02012-4 B-AWARD Scientific B-ORG research I-ORG and I-ORG development I-ORG fund I-ORG of I-ORG Zhejiang I-ORG Agriculture I-ORG and I-ORG Forestry I-ORG University I-ORG grant O number O 2016FR010 B-AWARD and O Zhejiang B-ORG Province I-ORG Basic I-ORG Public I-ORG Welfare I-ORG Research I-ORG Program I-ORG Project I-ORG grant O number O LGG21H280001 B-AWARD This O work O was O supported O by O grants O from O Livionex O Flow O through O NIH O SBIR O Phase O I, O NIAMS O R43 O AR062419 O and O by O the O Army B-ORG Navy I-ORG NIH I-ORG Air I-ORG Force I-ORG VA I-ORG and I-ORG Health I-ORG Affairs I-ORG to O support O the O AFIRM O II O effort O under O Award O No. O W81XWH-13-2-0054 B-AWARD The O US O Army O Medical O Research O Acquisition O Activity O 820 O Chandler O Street O Fort O Detrick O MD O 21702–5014 O is O the O awarding O and O administering O acquisition O office O Opinions O interpretations O conclusions O and O recommendations O are O those O of O the O authors O and O are O not O necessarily O endorsed O by O the O Department O of O Defense O Support O was O also O provided O in O part O by O National B-ORG Institute I-ORG of I-ORG Environmental I-ORG Health I-ORG Sciences I-ORG P30 O ES006676 O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG P50 O GM060338 I-AWARD to O DNH O and O R01 B-AWARD GM112936 I-AWARD to O CCF O and O Shriners B-ORG Hospitals I-ORG for I-ORG Children I-ORG 84202 O to O AE O and O 80500 B-AWARD to O DNH O None O of O the O study O sponsors O had O any O role O in O the O study O design O in O the O collection O analysis O or O interpretation O of O the O data O in O the O writing O of O the O report O or O in O the O decision O to O submit O the O article O for O publication O This O research O was O funded O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Provincial I-ORG Universities I-ORG 2022KYYWF-0298 O the O Research B-ORG Fund I-ORG of I-ORG the I-ORG Fourth I-ORG Affiliated I-ORG Hospital I-ORG of I-ORG Harbin I-ORG Medical I-ORG University I-ORG No. O HYDSYRCYJ02 B-AWARD the O Harbin B-ORG Medical I-ORG University I-ORG High-Level I-ORG Introduction I-ORG of I-ORG Talent I-ORG Research I-ORG Start-up I-ORG Fund I-ORG No. O 31011210004 B-AWARD and O the O National B-ORG Science I-ORG Foundation I-ORG No. O 22002096 B-AWARD The O authors O are O grateful O for O the O financial O support O provided O by O the O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior—Brasil I-ORG CAPES O No.76 O de I-AWARD 14/04/2010 O Decanato B-ORG de I-ORG Pesquisa I-ORG e I-ORG Inovação I-ORG e I-ORG de I-ORG Pós-Graduação I-ORG grant O nos O DPI/DPG O No. O 23106.011913/2023-73 B-AWARD and O Fundação B-ORG de I-ORG Apoio I-ORG à I-ORG Pesquisa I-ORG do I-ORG Distrito I-ORG Federal I-ORG No. O 03/2016 B-AWARD This O research O was O funded O by O the O University-Industry O Collaboration O Program O UIM/329 O Innovation O and O Technology O Fund O Hong O Kong O government O Hong O Kong O SAR O China O and O Lee’s O Pharmaceutical O HK) O Ltd O V.W.Y.L O also O received O research O funding O from O the O General B-ORG Research I-ORG Fund I-ORG #17114814 O 17121616 B-AWARD 14168517 B-AWARD Research O Impact O Fund O #R4015-19F O R4017-18 O the O Health B-ORG and I-ORG Medical I-ORG Research I-ORG Fund I-ORG HMRF#15160691 O the O Health O and O Medical O Research O Fund O the O Food O and O Health O Bureau O The O Government O of O the O Hong O Kong O Special O Administrative O Region O China O and O the O Hong B-ORG Kong I-ORG Cancer I-ORG Fund O Hong O Kong O SAR O China O Y.L O received O funding O supports O Postdoctoral O Hub O PH-ITF O Ref O PiH/052/18 B-AWARD of I-AWARD UIM/329 O from O the O Innovation O and O Technology O Fund O Hong O Kong O government O V.W.Y.L O and O Y.L O also O received O research O funding O from O the O Lee O Hysan O Foundation O Research O Grant O and O Endowment O Fund O Research O Grant O Schemes O 2018–2019 O CA11281 O V.W.Y.L O and O 2019–2020 O CA11286 O V.W.Y.L O United O College O the O Chinese O University O of O Hong O Kong O Hong O Kong O SAR O China O This O work O was O supported O by O theNational O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China(51875109 O theChina O Postdoctoral I-ORG Science I-ORG Foundation(2016M600641 O and O theNatural O Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province(2018A030310546 O This O work O was O supported O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O No.81573125 O No. I-AWARD 81872621 I-AWARD and I-AWARD No.81102130 O toProf.Longying O Zha O in O the O design O of O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O China O No. O 2014A030313313 O toProf.Longying O Zha O in O the O collection O of O data O the O Research B-ORG Start-up I-ORG Plan I-ORG of I-ORG Southern I-ORG Medical I-ORG University I-ORG No.CX2016N012 O toProf.Longying O Zha O in O the O analysis O and O interpretation O of O data O and O the O Scientific B-ORG Enlightenment I-ORG Plan I-ORG of I-ORG Southern I-ORG Medical I-ORG University I-ORG No. O B219339024 O toProf O Longying O Zha O and O Yuanhao O Wei O in O the O collection O of O data O This O project O was O supported O by O The B-ORG National I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2014CB910600 O The B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81273540 O and I-AWARD 81472684 O and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2042017KF0242 O This O work O was O supported O by O the O grants O of O the O Zhejiang B-ORG Province I-ORG Public I-ORG Welfare I-ORG Technology I-ORG Application I-ORG Research I-ORG Project I-ORG LGN18C150007 O the O Young O talents O training O program O of O Zhejiang B-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG 2017R05R08E01 O and O the O Public B-ORG development I-ORG special I-ORG of I-ORG Zhejiang I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG 617CF0101G O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior O Brazil O CAPES O Finance O Code I-AWARD 001 O CAPES O also O provided O financial O support O to O P.K.F.S O PhD O scholarship O and O PDSE O to O visit O the O Kapheim's O Laboratory O CNPq O O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG granted O research O sponsorship O to O M.C.A O 306932/2016-4 O and O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo I-ORG FAPESP O supported O research O projects O by O M.C.A O 2013/12530-4 O and O 2016/24669-5 B-AWARD This O project O is O supported O by O Agriculture O and O Food O Research O Initiative O competitive O award O no. O 2018-67014-27542 B-AWARD from O the O USDA O National B-ORG Institute I-ORG of I-ORG Food I-ORG and I-ORG Agriculture O This O research O was O supported O by O the O Utah B-ORG Agricultural I-ORG Experiment I-ORG Station I-ORG Project O 1297 B-AWARD Utah O State O University O and O approved O as O journal O paper O number O 9235 O 1. O Research B-ORG on I-ORG the I-ORG impact I-ORG of I-ORG wind I-ORG erosion I-ORG on I-ORG organic I-ORG carbon I-ORG in I-ORG arid I-ORG areas I-ORG based I-ORG on I-ORG polynuclide I-ORG combined I-ORG tracer I-ORG analysis O 41661057 O 2. O Characteristics B-ORG of I-ORG the I-ORG unorganized I-ORG dust I-ORG emission I-ORG project I-ORG and I-ORG its I-ORG impact I-ORG on I-ORG the I-ORG surrounding I-ORG vegetation O 41601572 O 3. O Xinjiang B-ORG Uygur I-ORG Autonomous I-ORG Region I-ORG innovation I-ORG environment I-ORG Construction I-ORG special I-ORG project I-ORG I-ORG Science I-ORG and I-ORG technology I-ORG innovation I-ORG base I-ORG construction I-ORG project I-ORG PT2107 O 4. O The B-ORG Strategic I-ORG Pilot I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XAD20040400 O The O authors O are O grateful O for O the O financial O support O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0400902 O Nation B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31872907 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Beijing I-ORG KM201610858001 O This O work O was O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32001919 O Young B-ORG Elite I-ORG Scientists I-ORG Sponsorship I-ORG Program I-ORG by I-ORG CAST I-ORG 2022QNRC001 O and O the O Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG No. O 1610162022048 B-AWARD FM O and O MD O were O supported O by O the O Deutsche B-ORG Forschungsgemeinschaft I-ORG grant O DU1319/1-1 B-AWARD CQ O is O funded O by O an O EPSRC B-ORG Career I-ORG Acceleration I-ORG Fellowship—EP/H003851/1 O CdeV O were O supported O by O the O EU B-ORG EraNet I-ORG BiodivErsA I-ORG program I-ORG BioMarKs I-ORG grant O 2008-6530 B-AWARD and O the O French B-ORG government I-ORG “Investissements I-ORG d’Avenir” I-ORG project I-ORG OCEANOMICS I-ORG ANR-11-BTBR-0008 O and O the O EU B-ORG FP7 I-ORG program I-ORG MicroB3 I-ORG contract O number O 287589 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O T.J O is O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 31470453 B-AWARD X.-D.Z O by O the O National O Natural O Science O Foundation O of O China O no. O 11401562 B-AWARD Q.-Q.H O by O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG nos O 2013M541036 B-AWARD and O 2014T70122 B-AWARD T.J O J.-J.W O and O R.M O by O the O European B-ORG Research I-ORG Council I-ORG AdG O 249347 O Y.T O by O the O National O Natural O Science O Foundation O of O China O nos O 31270439 B-AWARD and O 11471311 B-AWARD T.J O Q.-Q.H O J.-J.W O R.M O and O Y.T O are O also O funded O by O an O International O Partnership O grant O from O the O British B-ORG Academy I-ORG IPM O 120180 O This O work O was O supported O by O the O project O SAF B-AWARD 2010‐22241 I-AWARD Ministerio O de I-ORG Ciencia I-ORG e I-ORG Innovación O Oscar O Molina O is O the O recipient O of O a O grant O fromUniversitat O Autònoma I-ORG de I-ORG Barcelona(UAB/PIF2007 O and O a O mobility O studentship O from O the O same O institution O UAB/ESTPIF0042 O Emanuela O Volpi O is O supported O by O theWellcome O Trust(Wellcome O Trust O Core O Award O 090532/Z/09/Z B-AWARD The O Authors O would O like O to O thank O the O Staff O at O the O Molecular O Cytogenetics O and O Microscopy O Core O of O the O Wellcome O Trust O Centre O for O Human O Genetics O University O of O Oxford O for O expert O technical O assistance O The O DNA O probes O for O Fiber-FISH O were O kindly O provided O by O the O Wellcome O Trust O Sanger O Institute O Cambridge O U.K O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 52202113 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2021M702550 B-AWARD the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Programs I-ORG of I-ORG Shaanxi I-ORG No. O 2020SF-426 B-AWARD 2021GY-295 B-AWARD and O the O Lifting B-ORG Program I-ORG for I-ORG Young I-ORG Talents I-ORG of I-ORG Shaanxi I-ORG Science I-ORG and I-ORG Technology I-ORG Association I-ORG No. O 20220422 B-AWARD This O study O was O financially O supported O by O the O Fundação O Faculdade O de O Medicina O FFM O Conselho O Regional O de O Medicina O do O Estado O de O São O Paulo O Cremesp O and O Conselho O Federal O de O Medicina O CFM O agreement O 0075/2015 O which O also O contributed O by O making O their O database O fully O available O This O study O was O also O funded O by O the O UK O Medical B-ORG Research I-ORG Council I-ORG MRC/R022747/1 O and O the O Fundação O de O Amparo O à O Pesquisa O do O Estado O de O São O Paulo O FAPESP O project O number O 17/50356-7 B-AWARD Mario O Scheffer O was O given O a O postdoctoral O fellowship O from O the O Fundacion B-ORG Carolina I-ORG and O Tordesillas O Group O “Convocatória O C. I-AWARD 2018 O Estancia O Corta O Posdoctorale.” O Alex O Jones O Flores O Cassenote O was O given O a O postdoctoral O fellowship O from O the O Coordination O of O Superior O Level O Staff O Improvement O O CAPES B-ORG 88882.315718/2019-01 O This O study O was O funded O by O the O Basic B-ORG Science I-ORG Research I-ORG Program I-ORG through I-ORG the I-ORG National I-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG ICT I-ORG I-ORG Future I-ORG Planning I-ORG Republic I-ORG of I-ORG Korea I-ORG Grant O number O 2017R1A2B3008214 B-AWARD to O Eun O Lee O the O Korea B-ORG Health I-ORG Technology I-ORG R&D I-ORG Project I-ORG through I-ORG the I-ORG Korea I-ORG Health I-ORG Industry I-ORG Development I-ORG Institute I-ORG the I-ORG Ministry I-ORG of I-ORG Health I-ORG and I-ORG Welfare I-ORG Republic I-ORG of I-ORG Korea I-ORG Grant O number O HI13C0715 B-AWARD to O Hyeon O Chan O Kim O and O the O Intelligence B-ORG Information I-ORG Expansion I-ORG Support I-ORG System I-ORG for I-ORG Private I-ORG Organizations I-ORG supervised I-ORG by I-ORG the I-ORG National I-ORG IT I-ORG Industry I-ORG Promotion I-ORG Agency I-ORG Grant O number O A0602-19-1009 B-AWARD to O Eun O Lee O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O partly O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG grant O no. O 2018YFD0500600 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 31572409 B-AWARD Hubei B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 2018CFA071 B-AWARD This O research O was O funded O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O No. O 81872673 B-AWARD the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O No. O 2017YFC1200203 B-AWARD the B-ORG Original I-ORG Research I-ORG Support I-ORG Project I-ORG of I-ORG Fudan I-ORG University I-ORG grant O No. O IDF201011 B-AWARD to O LJ. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG grant O number O ZR2021ME119 B-AWARD ZR2022QE138 B-AWARD and O ZR2017BEE016 B-AWARD funded O by O Scientific B-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Higher I-ORG Education I-ORG Institution I-ORG of I-ORG Xinjiang I-ORG grant O number O XJEDU2021Y014 B-AWARD funded O by O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Yantai I-ORG University I-ORG grant O number O TM17B19 B-AWARD This O research O was O supported O by O Hainan B-ORG Yazhou I-ORG Bay I-ORG Seed I-ORG Laboratory I-ORG project O of O B21HJ1002 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 32272169 B-AWARD 32172037 B-AWARD and O 32000377 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grant O No. O BK20201322 B-AWARD This O research O was O funded O by O the O “National O Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China O grant O number O 2017YFB0307600” B-AWARD “Natural O Science I-ORG Foundation I-ORG of I-ORG China O grant O number O U1663226” B-AWARD and O the O “Fundamental O Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities O grant O number O DUT17ZD103” B-AWARD This O work O was O supported O by O grants O from O the O Deutsche B-ORG Forschungsgemeinschaft I-ORG DFG O German O Research O Foundation)—Project-ID O 431984000-SFB B-AWARD 1453 O to O E.N.-H O G.W O I.J.F O T.W O and O A.G O and O by O the O Swiss B-ORG National I-ORG Science I-ORG Foundation I-ORG SNF O via O the O NCCR O Kidney.CH O and O project O 310030_189102/1 O and O the O European B-ORG Union’s I-ORG Horizon I-ORG 2020 I-ORG research I-ORG and I-ORG innovation I-ORG programme I-ORG under O an O ERC-StrG O DiRECT O grant O agreement O No. O 804474 B-AWARD to O S.S.L O This O work O was O supported O by O the O JSPS B-ORG KAKENHI I-ORG 263395 O Grants-in-Aid B-ORG for I-ORG Scientific I-ORG Research I-ORG 15H05790 O 15H1155 B-AWARD 15K15417 B-AWARD Japan B-ORG Science I-ORG and I-ORG Technology I-ORG Agency I-ORG Precursory I-ORG Research I-ORG for I-ORG Embryonic I-ORG Science I-ORG and I-ORG Technology I-ORG PRESTO O 16021031300 O and O Japan B-ORG Agency I-ORG for I-ORG Medical I-ORG Research I-ORG and I-ORG Development I-ORG AMED O 16ek0410011h0003 O 16he0902003h0002 B-AWARD This O work O was O supported O by O the O German B-ORG Research I-ORG Foundation I-ORG DFG O priority O program O SPP2002 O ‘Small O Proteins O in O Prokaryotes O an O Unexplored O World’ O grants O grant O SH580/7–1 B-AWARD and O SH580/7–2 B-AWARD to O CMS O grant O BA O 2168/21–2 O to O RB, O grant O BE O 3869/5–1 O and O BE O 3869/5–2 O to O DB, O and O grant O Ev O 42/7–1 O to O EEH O Additional O funding O was O received O from O the O Swiss B-ORG National I-ORG Science I-ORG Foundation I-ORG grant O 197391 B-AWARD to O CHA O and O from O DFG O GRK2355 O project O number O 325443116 O to O EEH O and O Germany's O Excellence O Strategy O CIBSS—EXC-2189–Project O ID O 390939984 O to O RB. O Computational O resources O were O provided O by O the O BMBF-funded O de.NBI B-ORG Cloud O within O the O German O Network O for O Bioinformatics O Infrastructure O de.NBI O 031A532B O 031A533A B-AWARD 031A533B B-AWARD 031A534A B-AWARD 031A535A B-AWARD 031A537A B-AWARD 031A537B B-AWARD 031A537C B-AWARD 031A537D B-AWARD 031A538A B-AWARD This O research O was O funded O by O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG Grant O No. O 2019GSF109036 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 41977124 B-AWARD Science B-ORG and I-ORG Technology I-ORG Support I-ORG Plan I-ORG for I-ORG Youth I-ORG Innovation I-ORG of I-ORG Colleges I-ORG and I-ORG Universities I-ORG in I-ORG Shandong I-ORG Province I-ORG Grant O No. O 2020KJD005 B-AWARD This O study O was O funded O by O the O Health B-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG Sichuan(No O 16PJ484 B-AWARD Sichuan B-ORG Medical I-ORG Association I-ORG No. O S16070 B-AWARD and O Clinical B-ORG Research I-ORG and I-ORG Transformation I-ORG Project I-ORG of I-ORG Sichuan I-ORG provincial I-ORG People’s I-ORG Hospital(No O 2018LY09 B-AWARD These O funding O sources O had O no O role O in O the O design O of O the O study O and O did O not O have O any O role O in O collection O analysis O and O interpretation O of O data O or O in O writing O the O manuscript O This O research O was O funded O by O National B-ORG S&T I-ORG Major I-ORG Project I-ORG No. O 2018ZX10301201 B-AWARD 2017ZX10203205 B-AWARD Innovative B-ORG Research I-ORG Groups I-ORG of I-ORG NSFC I-ORG No. O 81721091 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82027803 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Fund I-ORG No. O 81472870 O the O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG CIFMS O No. O 2016-I2M-1-002 O and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFC0901501 O The O present O research O was O supported O by O the O National B-ORG Institute I-ORG on I-ORG Drug I-ORG Abuse I-ORG # O DA037911 B-AWARD to O CF O the O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG # O FRN B-AWARD 156272 I-AWARD to O CF O and O the O Natural B-ORG Sciences I-ORG and I-ORG Engineering I-ORG Research I-ORG Council I-ORG of I-ORG Canada I-ORG # O RGPIN-2020-04703 B-AWARD to O CF O AM O was O supported O by O the O Laszlo O and O Etelka O Kollar O Fellowship O from O the O Faculty O of O Medicine O and O Health O Sciences O McGill O University O and O by O a O Postgraduate O Scholarship-Doctoral O PGS O D) O from O the O Natural O Sciences O and O Engineering O Research O Council O of O Canada O NSERC O This O work O was O supported O in O part O by O the O Social B-ORG Sciences I-ORG and I-ORG Humanities I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG under O Grant O 18YJC88002 B-AWARD in O part O by O the O Guangdong B-ORG Provincial I-ORG Key I-ORG Platform I-ORG and I-ORG Major I-ORG Scientific I-ORG Research I-ORG Projects I-ORG Featured I-ORG Innovation I-ORG Projects I-ORG under O Grant O 2017GXJK136 B-AWARD and O in O part O by O the O Guangzhou B-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Education I-ORG Project I-ORG under O Grant O 201709P14 B-AWARD The O study O was O supported O by O the O Joint B-ORG Research I-ORG Fund I-ORG for I-ORG Overseas I-ORG Natural I-ORG Science I-ORG of I-ORG China I-ORG 31429004 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31871482 O the O Key B-ORG Program I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81521002 O and O the O Science B-ORG Fund I-ORG for I-ORG Creative I-ORG Research I-ORG Groups I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81730038 O This O work O was O supported O by O the O Office B-ORG of I-ORG Naval I-ORG Research I-ORG Global I-ORG ONRG O grant O number O N00014-17-S-B001 B-AWARD SOR O Dr. O Christopher O A. O Lowry O is O supported O by O the O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health I-ORG grant O number O 1R21MH116263 B-AWARD the O Department O of O the O Navy O Office B-ORG of I-ORG Naval I-ORG Research I-ORG Multidisciplinary I-ORG University I-ORG Research I-ORG Initiative I-ORG MURI I-ORG Award I-ORG grant O number O N00014-15-1-2809 B-AWARD Department B-ORG of I-ORG Veterans I-ORG Affairs I-ORG Office I-ORG of I-ORG Research I-ORG and I-ORG Development I-ORG VA-ORD I-ORG RR&D I-ORG Small I-ORG Projects I-ORG in I-ORG Rehabilitation I-ORG Research I-ORG SPiRE O I21 O grant O number O 1 B-AWARD I21 I-AWARD RX002232-01 O Colorado B-ORG Clinical I-ORG I-ORG Translational I-ORG Sciences I-ORG Institute I-ORG CCTSI I-ORG Center I-ORG for I-ORG Neuroscience I-ORG grant O number O CNSTT-15-145 B-AWARD the O Colorado B-ORG Department I-ORG of I-ORG Public I-ORG Health I-ORG and I-ORG Environment I-ORG CDPHE O grant O number O DCEED-3510 B-AWARD and O the O Alfred O P. O Sloan O Foundation O grant O number O G-2016-7077 O Christopher O A. O Lowry O serves O on O the O Scientific O Advisory O Board O of O Immodulon O Therapeutics O Ltd O This O research O was O funded O by: O 1) O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O numbers O 81670472 B-AWARD 81672344 I-AWARD 81700502 I-AWARD and I-AWARD 81800538 O 2) O the O Outstanding B-ORG Young I-ORG Medical I-ORG Personnel I-ORG Training I-ORG Program I-ORG of I-ORG Shanghai I-ORG Health I-ORG Commission O grant O number O 2017YQ041 B-AWARD 3) O the O Yangfan B-ORG Project I-ORG of I-ORG Shanghai I-ORG Science I-ORG and I-ORG Technology I-ORG Commission O grant O number O 18YF1420000 B-AWARD 4) O the O Health B-ORG System I-ORG Innovation I-ORG Project I-ORG of I-ORG Shanghai I-ORG Putuo I-ORG Science I-ORG and I-ORG Technology I-ORG Commission O grant O number O ptkwws201901 B-AWARD The O present O study O was O supported O by O the O Jiangsu B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG grant O no. O BE2016750 B-AWARD Foundation B-ORG for I-ORG Key I-ORG Medical I-ORG Talents I-ORG in I-ORG Jiangsu I-ORG Province I-ORG grant O no. O ZDRCA2016096 B-AWARD Family B-ORG Planning I-ORG Research I-ORG Project I-ORG of I-ORG the I-ORG Army I-ORG grant O no. O 16JS012 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG grant O no. O BK20170620 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG grant O no. O 2017M613434 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O nos O 81701431 B-AWARD 81701440 B-AWARD and O 31701304 B-AWARD and O Six B-ORG Talent I-ORG Peaks I-ORG Project I-ORG in I-ORG Jiangsu I-ORG Province I-ORG grant O no. O 2017-WSW-033 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 31771941 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Key I-ORG Project I-ORG of I-ORG Henan I-ORG province I-ORG No. O 222102110040 B-AWARD the O Key B-ORG Scientific I-ORG Research I-ORG Projects I-ORG of I-ORG Universities I-ORG in I-ORG Henan I-ORG Province I-ORG No. O 21A550009 B-AWARD 22A550007 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Key I-ORG Project I-ORG of I-ORG Xinxiang I-ORG city I-ORG No. O GG2021022 B-AWARD This O work O was O supported O by O Wellcome B-ORG grant O number O 203105 B-AWARD Newcastle O University O Centre O for O Ageing O and O Vitality O supported O by O the B-ORG Biotechnology I-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG grant O number O L016354 B-AWARD UK O NIHR O Biomedical O Research O Centre O for O Ageing O and O Age-related O disease O award O to O the O Newcastle O upon O Tyne O Hospitals O NHS O Foundation O Trust O National O Institute O for O Health O Research O NIHR O and O the O UK O NHS O Specialist O Commissioners O which O funds O the O “Rare O Mitochondrial O Disorders O of O Adults O and O Children” O Diagnostic O Service O in O Newcastle O upon O Tyne O http://www.newcastle-mitochondria.com O This O work O also O received O infrastructure O support O from O the O Medical B-ORG Research I-ORG Council I-ORG MRC I-ORG Mitochondrial I-ORG Disease I-ORG Patient I-ORG Cohort I-ORG Study I-ORG UK I-ORG A I-ORG Natural I-ORG History I-ORG Study I-ORG and I-ORG Patient I-ORG Registry I-ORG grant O number O REC B-AWARD ref I-AWARD 13/NE/0326 O and O the O NIHR O Biomedical O Research O Centre O Newcastle O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81200491 O to O J.J O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2012CB966902 O to O D.M O Jiangsu B-ORG Province I-ORG Ordinary I-ORG University I-ORG Innovative I-ORG Research I-ORG Project I-ORG CXZZ12_0557 O and O Nanjing B-ORG Medical I-ORG University I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Fund I-ORG Project I-ORG 2010NJMU036 O to O J.J O The O research O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41571230 O 41230854 B-AWARD J1103510 B-AWARD the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 O grant O No. O 2015CB150504 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2662015PY016 O 2662015PY116 B-AWARD This O study O was O supported O in O part O by O Grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81371866 O International B-ORG Cooperation I-ORG Project I-ORG of I-ORG Guangzhou I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG 2016201604030021 O and O the B-ORG National I-ORG Grant I-ORG Program I-ORG on I-ORG key I-ORG Infectious I-ORG Disease I-ORG 2014ZX10002002-002 O The O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81400187 O and O 81230015 B-AWARD CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG 2016-I2M-1-002 O and O the O Beijing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG Z151100003915078 O This O work O was O supported O by O Artificial B-ORG Intelligence I-ORG Project I-ORG 2018AAA0102301 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 11401017 O 11671025 B-AWARD and O 11290141 B-AWARD Fundamental B-ORG Research I-ORG of I-ORG Civil I-ORG Aircraft I-ORG No. O MJ-F-2012-04 B-AWARD No O funding O body O played O any O role O in O the O design O of O the O study O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O study O was O supported O by O the B-ORG National I-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG of I-ORG China I-ORG NO.81870498,81500558 O Natural B-ORG Sciences I-ORG Foundation I-ORG of I-ORG Hunan I-ORG province I-ORG 2018JJ3785 O and O by O the O New B-ORG Xiangya I-ORG talent I-ORG projects I-ORG of I-ORG the I-ORG third I-ORG Xiangya I-ORG hospital I-ORG of I-ORG Central I-ORG South I-ORG University I-ORG 20180303 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O This O research O was O funded O by O the O Directorate B-ORG of I-ORG Research I-ORG Technology I-ORG and I-ORG Community I-ORG Services O the O Directorate B-ORG General I-ORG of I-ORG Higher I-ORG Education I-ORG Research I-ORG and I-ORG Technology O the O Indonesian B-ORG Ministry I-ORG of I-ORG Education I-ORG Culture I-ORG Research I-ORG and I-ORG Technology O grant O number O 157/E5/PG.02.00.PT/2022 B-AWARD No B-AWARD 1989.9/LL5-INT/PG.02.00/2022 O and O 028/Penel./LPPM-USD/V/2022 B-AWARD The O work O was O supported O by O the O grant O of O Key B-ORG projects I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG the I-ORG People’s I-ORG Republic I-ORG of I-ORG China I-ORG with I-ORG Yunnan I-ORG University I-ORG Applied I-ORG Basic I-ORG Research I-ORG Project I-ORG of I-ORG Yunnan I-ORG No. O 2018FD005 B-AWARD Major B-ORG science I-ORG and I-ORG technology I-ORG projects I-ORG of I-ORG Yunnan I-ORG Province I-ORG No. O 2018ZG016 B-AWARD The B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Yunnan I-ORG No. O 2017FB108 B-AWARD 2019FB136 O The B-ORG Scientific I-ORG Research I-ORG Fund I-ORG of I-ORG Yunnan I-ORG province I-ORG of I-ORG China I-ORG Kunming I-ORG Medical I-ORG University I-ORG Joint I-ORG Research I-ORG Project I-ORG No. O 2018FE001(-312 B-AWARD 2017FE467(-122 O The B-ORG Fund I-ORG of I-ORG Yunnan I-ORG Provincial I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG No. O 2018NS0283 B-AWARD 2016NS237 I-AWARD 2017NS213 I-AWARD 2018NS0234 O Yunnan B-ORG health I-ORG training I-ORG project I-ORG of I-ORG high I-ORG level I-ORG talents I-ORG No. O D-2017054 B-AWARD Yunnan B-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Clinical I-ORG Virology I-ORG No. O 2018DG010 B-AWARD The B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81860281 B-AWARD 82060669 O This O research O was O funded O by O the O Innovation B-ORG Team I-ORG and I-ORG Talents I-ORG Cultivation I-ORG Program I-ORG of I-ORG National I-ORG Administration I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine O grant O number O ZYYCXTD-D-202205 B-AWARD China B-ORG Agriculture I-ORG Research I-ORG System I-ORG of I-ORG MOF I-ORG and I-ORG MARA I-ORG CARS-21 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 32272007 B-AWARD This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32172902 O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2022YFD1801102 O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Gansu I-ORG Province I-ORG 20YF8NA028 O Special B-ORG project I-ORG for I-ORG transformation I-ORG of I-ORG scientific I-ORG and I-ORG technological I-ORG achievements I-ORG in I-ORG Inner I-ORG Mongolia I-ORG Autonomous I-ORG Region I-ORG of I-ORG China I-ORG 2021CG0024-02 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O No. I-AWARD 81874227 O Guangzhou B-ORG Health I-ORG Care I-ORG and I-ORG Cooperative I-ORG Innovation I-ORG Major I-ORG Project I-ORG No.201704020224 O Training B-ORG Project I-ORG of I-ORG Young I-ORG teacher I-ORG of I-ORG Sun I-ORG Yat-Sen I-ORG University I-ORG H1617 O and O the B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Huizhou I-ORG 170520181743174/2017Y229 O and O 180529101741637/2018Y305 B-AWARD This O work O has O been O carried O out O within O the O framework O of O the O EUROfusion O Consortium O funded O by O the O European B-ORG Union I-ORG via O the O Euratom O Research O and O Training O Programme O grant O agreement O No. O 101052200—EUROfusion B-AWARD Views O and O opinions O expressed O are O however O those O of O the O author(s O only O and O do O not O necessarily O reflect O those O of O the O European O Union O or O the O European O Commission O Neither O the O European O Union O nor O the O European O Commission O can O be O held O responsible O for O them O AP O also O acknowledges O with O thanks O the O financial O support O provided O by O “Strengthening O of O the O capacity O of O doctoral O studies O at O the O University B-ORG of I-ORG Latvia I-ORG within O the O framework O of O the O new O doctoral O model” O No. O 8.2.2.0/20/I/006 B-AWARD and O Scientific O Research O Project O for O Students O and O Young O Researchers O Nr. O SJZ/2021/5 B-AWARD implemented O at O the O Institute B-ORG of I-ORG Solid I-ORG State I-ORG Physics I-ORG University I-ORG of I-ORG Latvia I-ORG This O research O was O funded O by O theEunice O Kennedy I-ORG Shriver I-ORG National I-ORG Institute I-ORG on I-ORG Child I-ORG Health I-ORG and I-ORG Development(R21 O HD073610 O Principal O Investigators O Reed O and O Raj O Elizabeth O Reed O was O also O supported O by O theNational O Institute I-ORG of I-ORG Mental I-ORG Health(K01MH099969 O Principal O Investigator O Reed O Marissa O Salazar O was O supported O by O theNational O Institute I-ORG of I-ORG Drug I-ORG Abuse(T32 O DA023356 O Principal O Investigator O Strathdee O This O study O was O supported O by O Region B-ORG Örebro I-ORG län O Sweden O OLL-878081 O Nyckelfonden B-ORG Sweden I-ORG OLL-881491 O and O Analytic B-ORG Imaging I-ORG Diagnostics I-ORG Arena I-ORG AIDA O Sweden O The O main O funding O body O of O The O Swedish O CArdioPulmonary O bioImage O Study O SCAPIS O is O the O Swedish O Heart O and O Lung O Foundation O The O study O is O also O funded O by O the O Knut O and O Alice O Wallenberg O Foundation O the O Swedish O Research O Council O and O VINNOVA O Sweden’s O Innovation O Agency O In O addition O the O SCAPIS O pilot O received O support O from O the O Sahlgrenska O Academy O at O University O of O Gothenburg O and O Region O Västra O Götaland O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Project O No. O 21605047 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG Project O No. O 2017JJ3080 B-AWARD and O Hunan B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG Project O No. O 17C0627 B-AWARD This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81572012 O 81772217 B-AWARD 20180907 B-AWARD Guangdong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Project I-ORG 2016A030311025 O 2017A030313694 B-AWARD Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2018A050506038 O and O Key O project O of O Guangzhou O science O research O 201904020011 O to O H.J.P O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Fujian I-ORG Province O China O Grant O No. O 2017J01621 B-AWARD Fujian B-ORG Key I-ORG Laboratory I-ORG of I-ORG Innate I-ORG Immune I-ORG Biology I-ORG Grant O No. O 2015J1001 B-AWARD Fujian B-ORG Public I-ORG Welfare I-ORG Fund I-ORG Grant O No. O 2018R1023-15 B-AWARD This O work O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51507144 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O XDJK2019B021 O the B-ORG Chongqing I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG CSTC O No. O cstc2016jcyjA0400 O and O the O project O of O China O Scholarship O Council O CSC O This O study O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 31601351 B-AWARD to O Zemao O Yang O the O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG grant O number O ASTIP-IBFC01 B-AWARD to O Jianguang O Su, O the O National B-ORG Key I-ORG Technology I-ORG Support I-ORG Program I-ORG grant O number O 2013BAD01B03-13 B-AWARD to O Jianguang O Su, O and O the O Germplasm B-ORG Resources I-ORG Protection I-ORG Project I-ORG grant O number O 2016NWB044 B-AWARD to O Jianguang O Su. O This O research O was O funded O by O National O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O numbers O 21672082 O 81803438 O Natural O Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province O grant O numbers O ZR2019YQ31 O ZR2017BH038 I-AWARD JQ201721 I-AWARD ZR2018ZC0944 O Young O Taishan I-ORG Scholars I-ORG Program O grant O number O tsqn20161037 O and O Shandong O Talents I-ORG Team I-ORG Cultivation I-ORG Plan I-ORG of I-ORG University I-ORG Preponderant I-ORG Discipline O grant O number O 10027 O This O work O was O supported O by O the O Clinical B-ORG Research I-ORG Plan I-ORG of I-ORG SHDC I-ORG 16CR2042B O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81770023 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG 17ZR1418400 O This O work O was O financially O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Chongqing I-ORG grant O numbers O cstc2018jcyjA0864 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 31270091 B-AWARD 20762015 B-AWARD National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG grant O numbers O 2020YFC1522500 B-AWARD Chongqing B-ORG Key I-ORG Project I-ORG of I-ORG Cultural I-ORG Relics I-ORG Science I-ORG and I-ORG Technology I-ORG Protection I-ORG grant O numbers O 50000023T000002739316 B-AWARD and O Self-Supporting B-ORG Project I-ORG of I-ORG Chongqing I-ORG China I-ORG Three I-ORG Gorges I-ORG Museum I-ORG grant O numbers O 3GM2022-KTZ07 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81901006 O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG 2020A1515110051 O Scientific B-ORG Research I-ORG Talent I-ORG Cultivation I-ORG Project I-ORG of I-ORG Stomatological I-ORG Hospital I-ORG Southern I-ORG Medical I-ORG University I-ORG RC202005 O and O Science B-ORG Research I-ORG Cultivation I-ORG Program I-ORG of I-ORG Stomatological I-ORG Hospital I-ORG Southern I-ORG Medical I-ORG University I-ORG PY2020002 O This O work O is O supported O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos.81290342,31560049 O Yunnan B-ORG Province I-ORG Applied I-ORG Basic I-ORG Research I-ORG Projects I-ORG No.2016FB029 O The B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC1201904 O Development B-ORG Grant I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Infectious I-ORG Disease I-ORG Prevention I-ORG and I-ORG Control I-ORG No.2014SKLID103 O This O work O was O supported O by O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG 2021A1515110277 O Shenzhen B-ORG Natural I-ORG Science I-ORG Fund I-ORG 20200811205344001 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 12074 O 268 O the B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2018B030311048 O the B-ORG Shenzhen I-ORG Natural I-ORG Science I-ORG Fund I-ORG the O Stable O Support O Plan O Program O 20200814164819001 B-AWARD and O ARC B-ORG DECRA I-ORG fellowship I-ORG Grant O No. O DE210100692 B-AWARD The O PR-Louis B-ORG Stokes I-ORG Alliance I-ORG for I-ORG Minority I-ORG Participation I-ORG Bridge I-ORG to I-ORG the I-ORG Doctorate I-ORG Fellowship I-ORG HRD-0601843 O the O Ronald B-ORG E. I-ORG McNair I-ORG Program I-ORG of I-ORG the I-ORG University I-ORG of I-ORG Puerto I-ORG Rico I-ORG at I-ORG Humacao I-ORG P217A070213 O and O the O Center B-ORG for I-ORG Applied I-ORG Tropical I-ORG Ecology I-ORG and I-ORG Conservation I-ORG HRD-0734826 O provided O funding O to O Wilfredo O Falcón O in O partial O support O of O this O project O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Thailand B-ORG Research I-ORG Fund I-ORG and O Mahidol B-ORG University O grant O numbers O BRG6080006 B-AWARD IRN58W0002 B-AWARD and O IRN60W0002 O and O by O Mahidol O University O grant O number O A46/2562 B-AWARD The O APC O was O funded O by O the O Thailand O Research O Fund O and O Mahidol O University O C.C O was O supported O by O a O 2017 O Mahidol O University O Postgraduate O Scholarship O for O International O Students O J.J O is O supported O by O a O scholarship O from O the O Thailand O Research O Fund O grant O number O IRN5802PHDW04 B-AWARD under O IRN58W0002 O A.H O is O supported O by O a O scholarship O from O the O Thailand B-ORG Graduate I-ORG Institute I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG TGIST O Ph.D O Scholarship O grant O number O TG-22-14-59-005D B-AWARD This O work O was O supported O by O the B-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Projects I-ORG for O “Major O New O Drug O Innovation O and O Development” O 2013ZX09501014 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31521062 O 81270883 B-AWARD 30870996 B-AWARD 81471063 B-AWARD 31221002 B-AWARD 81170100 B-AWARD 81630008 B-AWARD and O 81370234 B-AWARD and O the B-ORG National I-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2013CB531200 O and O 2012CB518000 B-AWARD This O research O was O funded O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2022YFC2601200 B-AWARD the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31900317 B-AWARD the O National B-ORG Science I-ORG I-ORG Technology I-ORG Fundamental I-ORG Resources I-ORG Investigation I-ORG Program I-ORG of I-ORG China I-ORG No. O 2022FY100500 B-AWARD the O project O of O the O Northeast B-ORG Asia I-ORG Biodiversity I-ORG Research I-ORG Center I-ORG No. O NABRI202203 B-AWARD and O a O grant O No. O Y229YX5105 B-AWARD from O the O Key B-ORG Laboratory I-ORG of I-ORG the I-ORG Zoological I-ORG Systematics I-ORG and I-ORG Evolution I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences O This O study O was O funded O by O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Liwan I-ORG District I-ORG of I-ORG Guangzhou I-ORG 202004034 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82101609 O Scientific B-ORG Research I-ORG Project I-ORG of I-ORG Guangzhou I-ORG Bureau I-ORG of I-ORG Education I-ORG 202032762 O Guangzhou B-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 20211A011045 O Guangzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG and I-ORG Integrated I-ORG Traditional I-ORG Chinese I-ORG and I-ORG Western I-ORG Medicine I-ORG 20212A011018 O China B-ORG International I-ORG Medical I-ORG Exchange I-ORG Foundation I-ORG Z-2018-35-2002 O Guangzhou B-ORG Clinical I-ORG Characteristic I-ORG Technology I-ORG Project I-ORG 2019TS67 O and O Science B-ORG and I-ORG Technology I-ORG Program I-ORG Project I-ORG of I-ORG Guangzhou I-ORG 202102020658 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O Young O Offender O Institution O study O was O funded O by O the O Medical B-ORG Research I-ORG Council I-ORG and O the O Chief B-ORG Scientist I-ORG Office I-ORG grant O numbers O MC_UU_12017/11 B-AWARD and O SPHSU11 B-AWARD The O THRIVE O study O including O the O THRIVE O mother O study O reported O here O was O funded O by O the O Medical O Research O Council O and O the O Chief O Scientist O Office O grant O number O MC_UU_12017/11 O and O the O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG NIHR O grant O number O 11/3002.01 B-AWARD The O THRIVE O father O study O was O funded O as O a O Medical O Research O Council O doctoral O studentship O grant O number O 1310508 B-AWARD The O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O no. O 41676137 B-AWARD 31502169 B-AWARD AoShan B-ORG Talents I-ORG Program I-ORG supported I-ORG by I-ORG Qingdao I-ORG National I-ORG Laboratory I-ORG for I-ORG Marine I-ORG Science I-ORG and I-ORG Technology I-ORG no. O 2015ASTP-ES05 B-AWARD and O the O NSFC-Shandong B-ORG Joint I-ORG Fund I-ORG for I-ORG Marine I-ORG Ecology I-ORG and I-ORG Environmental I-ORG Sciences I-ORG no. O U1606404 B-AWARD The O present O research O was O supported O with O the O following O funding O sources O 1. O Contrato O Puente O Funder O Universidad B-ORG de I-ORG Almería O Award O Number O Contrato B-AWARD Puente I-AWARD Plan I-AWARD Propio I-AWARD 2016 O Authors O who O received O a O salary O Esteban O Salmerón O Sánchez O 2. O European B-ORG Social I-ORG Fund I-ORG and I-ORG Czech I-ORG Republic I-ORG Government O Award O Number O CZ.1.07/2.3.00/30.0022 B-AWARD Authors O who O received O a O salary O Stanislav O Španiel O 3. O Czech B-ORG Science I-ORG Foundation O Award O Number O 16-10809S B-AWARD Authors O who O received O a O salary O Stanislav O Španiel O 4. O Spanish B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Innovation O Award O Number O CGL2007-63563 B-AWARD 5. O Consejeria B-ORG de I-ORG Economía I-ORG Innovación I-ORG y I-ORG Ciencia I-ORG of I-ORG the I-ORG Junta I-ORG de I-ORG Andalucia I-ORG co-financed I-ORG with I-ORG FEDER O Award O Number O PO7-RNM-03217 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2019A1515010914 O Sanming B-ORG Project I-ORG of I-ORG Medicine I-ORG in I-ORG Shenzhen I-ORG SZSM201502035 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81701529 B-AWARD Special O Funds O for O Science O Technology O Development O of O Guangdong O Province O 2017A020214006 O and O National O Key O Research O O Developmental O Program O of O China O 2018YFC1003900 O The O work O is O partially O funded O by O Medical B-ORG University I-ORG of I-ORG Lodz I-ORG grant O no. O 503/3–015-01/503–31-006 B-AWARD National B-ORG Science I-ORG Centre I-ORG in I-ORG Poland I-ORG research O project O No. O 2016/21/D/NZ7/01548 B-AWARD and O the O Academy B-ORG of I-ORG Finland I-ORG grant O number O 307057 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21675091 O 21574072 B-AWARD 51703105 B-AWARD 21874078 B-AWARD the O Taishan B-ORG Young I-ORG Scholar I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG tsqn20161027 O the O Major O Science O and O Technology O Innovation O Project O of O Shandong O Province O 2018CXGC1407 O the O Key O Research O and O Development O Project O of O Shandong O Province O 2016GGX102028 O 2016GGX102039 B-AWARD 2017GGX20111 B-AWARD the O Project O of O Shandong O Province O Higher O Educational O Science O and O Technology O Program O J15LC20 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2017BEM012 O the O People’s O Livelihood O Science O and O Technology O Project O of O Qingdao O 166257nsh O 173378nsh B-AWARD the O Innovation O Leader O Project O of O Qingdao O 168325zhc O and O the O First O Class O Discipline O Project O of O Shandong O Province O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O U1801681 B-AWARD 82001768 B-AWARD Key B-ORG Areas I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Guangdong I-ORG Grant O No. O 2019B020235001 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No. O 20ykpy102 B-AWARD Guangdong B-ORG Province I-ORG Universities I-ORG and I-ORG Colleges I-ORG Pearl I-ORG River I-ORG Scholar I-ORG Funded I-ORG Scheme I-ORG 2017 O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG Grant O No. O 2019A1515110189 B-AWARD Guangdong B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2017A030313777 B-AWARD Medical B-ORG science I-ORG and I-ORG Technology I-ORG Research I-ORG Fund I-ORG of I-ORG Guangdong I-ORG Province I-ORG Grant O No. O A2020074 B-AWARD The O funding O bodies O played O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81602426 B-AWARD Science B-ORG and I-ORG Technology I-ORG Projects I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG grant O number O 2014A020212100 B-AWARD and I-AWARD 2016A020215082 O the O Medical B-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Fund I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG grant O number O A2015003 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG grant O number O 2016A030310198 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O by O Beijing B-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospitals’ I-ORG Ascent I-ORG Plan I-ORG DFL20190203 B-AWARD Beijing B-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospitals I-ORG Clinical I-ORG Medicine I-ORG Development I-ORG of I-ORG Special I-ORG Funding I-ORG Support I-ORG ZYLX201704 O National B-ORG Key I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2015BAll6H00 O and O High B-ORG Level I-ORG Health I-ORG Technical I-ORG Personnel I-ORG of I-ORG Bureau I-ORG of I-ORG Health I-ORG in I-ORG Beijing I-ORG 2014-2-005 O Brazilian B-ORG Council I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Development I-ORG CNPq O for O the O scholarship O and O the O Brazilian O Agricultural O Research O Corporation O Embrapa O SEG B-AWARD 20.18.01.021.00.00 O Brazilian B-ORG agency I-ORG Coordenação I-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior—Programa I-ORG de I-ORG Apoio I-ORG à I-ORG Pós-Graduação I-ORG CAPES-PROAP O n. B-AWARD 8881.707827/2022-01 O and O Coordenação B-ORG de I-ORG Aperfeicoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG n. O 001 O This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG foundation I-ORG of I-ORG China I-ORG 82170523 O Key B-ORG Medical I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Shanxi I-ORG Province I-ORG 2020XM01 O Shanxi B-ORG “1331” I-ORG Project I-ORG Quality I-ORG and I-ORG Efficiency I-ORG Improvement I-ORG Plan I-ORG 1331KFC O and O Basic B-ORG Research I-ORG Program I-ORG of I-ORG Shanxi I-ORG Province I-ORG 202103021223238 O A.F O was O funded O by O a O CRUK O studentship O C16420/A12995 O E.C O by O CRUK O and O Barts B-ORG Charity I-ORG grants O A27781 O G-002189 B-AWARD and O L.F O by O a O Breast B-ORG Cancer I-ORG Now I-ORG project O award O 2017NovPR988 O This O work O was O also O supported O by O a O Cancer B-ORG Research I-ORG UK I-ORG Centre O Grant O to O Barts O Cancer O Institute O A25137 O This O research O was O funded O by O ANR-16-CE07-0024 B-AWARD GATE I-AWARD from O the O French B-ORG state I-ORG managed O by O the O National O Research O Agency O under O the O Investments O for O the O Future O program O Shiwei O Ren O thanks O the O China B-ORG Scholarship I-ORG Council I-ORG for O a O PhD O fellowship O No. O 201808070090 B-AWARD and O the O fellowship O of O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2022TQ0399 B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC1000402 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 81571445 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2016A030313178 O for O X.F O the O Guangdong B-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Prevention I-ORG and I-ORG Control I-ORG for I-ORG Severe I-ORG Clinical I-ORG Animal I-ORG Disease I-ORG 2013A061401013 O for O S.L O and O X.F O the O Shenzhen B-ORG Basic I-ORG Research I-ORG Fund I-ORG JCYJ20150521094519488 O for O X.F O and O JCYJ20170413165233512 O for O J.Z O and O X.F O the O Public B-ORG Welfare I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017A020211033 O for O J.Z O the O Natural O Science O Foundation O of O Research O Team O 2016A030312006 O and O the O Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG JCYJ20150521094519473 O and O JCYJ20160429191503002 B-AWARD for O L.C O The O work O was O supported O by O grants O from O the O French B-ORG Agence I-ORG Nationale I-ORG de I-ORG la I-ORG Recherche I-ORG to O M.J O and O V.V O ANR-18-CE11-0014-02 O from O the O Fond B-ORG de I-ORG la I-ORG Recherche I-ORG Médicale I-ORG FRM O grant O “Equipe O 2017” O DEQ20170336754 B-AWARD to O M.J O and O from O the O FINOVI O Fundation O to O M.J O and O V.V O We O acknowledge O the O Synchrotron O SOLEIL O for O the O allocation O of O beamtime O on O Proxima1 O and O Swing O This O work O used O the O platforms O of O the O Grenoble B-ORG Instruct-ERIC I-ORG center I-ORG ISBG O UAR B-AWARD 3518 I-AWARD CNRS-CEA-UGA-EMBL O within O the O Grenoble O Partnership O for O Structural O Biology O PSB O supported O by O FRISBI B-ORG ANR-10-INBS-0005-02 O and O GRAL O financed O within O the O University B-ORG Grenoble I-ORG Alpes I-ORG graduate I-ORG school I-ORG Ecoles O Universitaires O de O Recherche O CBH-EUR-GS O ANR-17-EURE-0003 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21276196 O and O 21406167 B-AWARD Key B-ORG Project I-ORG of I-ORG Chinese I-ORG Ministry I-ORG of I-ORG Education I-ORG 213004A O and O Tianjin B-ORG Programs I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG 15ZCZDSY00510 O The O authors O are O grateful O to O the O EU B-ORG PRIMA I-ORG program O and O the O Portuguese O Foundation O for O Science O and O Technology O FCT O for O funding O the O ArtiSaneFood O project O PRIMA/0001/2018 O and O for O financial O support O through O national O funds O FCT/MCTES B-ORG to O CIMO O UIDB/00690/2020 O and O SusTEC O LA/P/0007/2021 O This O study O was O supported O by O FCT O under O the O scope O of O the O strategic O funding O of O UIDB/04469/2020 B-AWARD unit O and O BioTecNorte O operation O NORTE-01-0145-FEDER-000004 O funded O by O the O European B-ORG Regional I-ORG Development I-ORG Fund I-ORG under O the O scope O of O Norte2020—Programa O Operacional O Regional O do O Norte O This O work O has O been O supported O by O the O Ministry B-ORG of I-ORG Science I-ORG Technological I-ORG Development I-ORG and I-ORG Innovation I-ORG of I-ORG the I-ORG Republic I-ORG of I-ORG Serbia I-ORG 451-03-47/2023-01/200007 O B.N O Silva O and O M. O Añibarro-Ortega O acknowledge O the O financial O support O provided O by O FCT O through O the O Ph.D O grants O SFRH/BD/137801/2018 O and O 2020.06297.BD O respectively O E. O Pereira O 2021.03908.CEECIND O R.C O Calhelha O L. O Barros O and O U. O Gonzales-Barron O acknowledge O the O national O funding O by O FCT O P.I O through O the O Individual O and O Institutional O Scientific O Employment O Program O contract O C. O Caleja O is O grateful O for O her O contract O through O the O project O Healthy-PETFOOD O POCI-01-0247-FEDER-047073 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31260545 O Special B-ORG Fund I-ORG for I-ORG Agro-scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG 201303059 O Natural B-ORG Science I-ORG Foundation I-ORG Project I-ORG of I-ORG Inner I-ORG Mongolia I-ORG Autonomous I-ORG Region I-ORG 2014BS0333 O and O Young B-ORG Scholars I-ORG Innovative I-ORG Foundation I-ORG for I-ORG Academy I-ORG of I-ORG Agriculture I-ORG and I-ORG Stockbreeding I-ORG Sciences I-ORG of I-ORG Inner I-ORG Mongolia I-ORG Autonomous I-ORG Region I-ORG 2013QNJJM05 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81830120 B-AWARD to O QL O National O Natural O Science O Foundation O of O China O No. O 81573749 B-AWARD to O QJ O National O Natural O Science O Foundation O of O China O No. O 81673783 B-AWARD No. O 81874405 B-AWARD to O XL O National O Natural O Science O Foundation O of O China O No. O 81603457 B-AWARD to O ZFH O National O Natural O Science O Foundation O of O China O No. O 81874399 B-AWARD to O HRZ O Science B-ORG Foundation I-ORG of I-ORG Shanghai I-ORG Committee I-ORG of I-ORG Science I-ORG Project I-ORG No. O 16401970500 B-AWARD to O QL O Shanghai B-ORG Rising-Star I-ORG Program I-ORG No. O 18QA1404100 B-AWARD to O XL O The O present O work O was O supported O by O a O personalized O medicine O grant O from O Alpe O D’HuZes O AdH)/KWF O PROPER O entitled O “Near-patient O prostate O cancer O models O for O the O assessment O of O disease O prognosis O and O therapy” O UL2014-7058 O SNF B-AWARD 31003A_169352 I-AWARD from O Swiss B-ORG National I-ORG Science I-ORG Foundation O FP7 O GA O 316125 O from O European O Commission O and O a O MAESTRO O grant O 2012/06/A O NZ1/0008 O from O National B-ORG Science I-ORG Center I-ORG This O work O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31601292 O and I-AWARD 31570335 O the O International B-ORG Science I-ORG and I-ORG Technology I-ORG Cooperation I-ORG and I-ORG Exchanges I-ORG Program I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2017HH0076 O the O Applied B-ORG Basic I-ORG Research I-ORG Programs I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2016JY0010 O and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0101000 O 2016YFD0102000 I-AWARD and I-AWARD 2016YFD0100100 O Department B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Government I-ORG of I-ORG India I-ORG for O the O project O grant O to O conduct O this O study O Project O code O SR/SO/AS-08/2009 B-AWARD NPM B-ORG was O funded O by O Rufford O Small O Grants O #14448-1 O and O Mohammed B-ORG Bin I-ORG Zayed I-ORG Species I-ORG Conservation I-ORG Fund I-ORG #12053708 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2017YFC0108500 O the O National B-ORG Key I-ORG Technology I-ORG Support I-ORG Program I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2015BAI01B11 O and O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 11805247 O This O work O was O supported O by O the O China B-ORG Natural I-ORG National I-ORG Science I-ORG Foundation I-ORG 81573067 O and O 81901972 B-AWARD the B-ORG Joint I-ORG construction I-ORG project I-ORG between I-ORG Jilin I-ORG province I-ORG and I-ORG provincial I-ORG colleges I-ORG SXGJQY2017-12 O the O Jilin B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Plan I-ORG 20190304044YY O the O Innovative B-ORG special I-ORG industry I-ORG fund I-ORG project I-ORG in I-ORG Jilin I-ORG province I-ORG 2018C049-2 O and O the B-ORG Open I-ORG Research I-ORG Project I-ORG of I-ORG the I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Industrial I-ORG Control I-ORG Technology I-ORG Zhejiang I-ORG University I-ORG China I-ORG ICT1800381 O Jilin O Province I-ORG Department I-ORG of I-ORG Education I-ORG no. O JJKH20191063KJ B-AWARD Jilin B-ORG City I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Development I-ORG Plan I-ORG Project I-ORG 201831745 O and O Jilin O Medical I-ORG College I-ORG Doctoral I-ORG Research I-ORG Foundation I-ORG Project I-ORG JYBS2018011 O We O would O like O to O thank O Editage O www.editage.cn O for O English O language O editing O This O work O was O supported O by O the O National B-ORG Research I-ORG Development I-ORG and I-ORG Innovation I-ORG Office I-ORG under O the O contract O number O 2020-1.1.6-JÖVŐ-2021-00004 B-AWARD and O by O the O ELTE B-ORG Thematic I-ORG Excellence I-ORG Programme I-ORG supported I-ORG by I-ORG the I-ORG Hungarian I-ORG Ministry I-ORG for I-ORG Innovation I-ORG and I-ORG Technology I-ORG SzintPlusz_1117 O This O study O was O supported O by O the O National B-ORG Laboratories I-ORG Excellence I-ORG program I-ORG as O part O of O the O National O Tumor O Biology O Laboratory O project O 2022-2.1.1-NL-2022-00010 O by O the O Hungarian B-ORG Thematic I-ORG Excellence I-ORG Programme I-ORG TKP2021-EGA-44 O and O by O the O National B-ORG Drug I-ORG Research I-ORG and I-ORG Development I-ORG Laboratory I-ORG PharmaLab I-ORG project I-ORG RRF-2.3.1-21-2022-00015 O sponsored O by O the O NRDI O Office O This O study O was O partially O supported O by O a O grant O subwencja O naukowa O of O the O University B-ORG of I-ORG Szczecin I-ORG Poland I-ORG Institute O of O Marine O and O Environmental O Studies O 503-0013-230000-01 B-AWARD awarded O to O WP O and O a O grant-in-aid O from O the O Japan B-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG KAKEN O No. O 19H03032 B-AWARD awarded O to O SO. O Additionally O UMS B-ORG Project I-ORG SDN0073-2019 B-AWARD was O awarded O to O BAVM O E.J.B O receives O funding O from O the O U.K O Medical B-ORG Research I-ORG Council I-ORG MR/P012418/1 O ERA-NET B-ORG NEURON B-AWARD MR/R005532/1 O the O International B-ORG Spinal I-ORG Research I-ORG Trust I-ORG BBS002 O and O the O Rosetrees B-ORG Trust I-ORG A1384 O This O work O was O supported O by O a O Longer O and O Larger O LoLa O grant O from O theBiotechnology O and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG BBSRCgrant O numbers O BB/G020744/1 B-AWARD BB/G019177/1 B-AWARD BB/G019274/1 B-AWARD and O BB/G018553/1 B-AWARD the O UK O Department O for O Environment O Food O and O Rural O Affairs O and O Zoetis O formerly O Pfizer O Animal O Health O awarded O to O the O Bacterial O Respiratory O Diseases O of O Pigs-1 O Technology O BRaDP1T O consortium O MTGH O was O supported O by O theWellcome O Trust(grant O number O 098051 B-AWARD RS O and O LF O were O supported O by O theHungarian O Scientific I-ORG Research I-ORG Fund(OTKA O 112826 O Genome O sequencing O was O provided O by O MicrobesNG O www.microbesng.uk O which O is O supported O by O theBBSRC(grant O number O BB/L024209/1 B-AWARD This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51675242 O 51605439 B-AWARD Six B-ORG Talent I-ORG Peaks I-ORG Project I-ORG in I-ORG Jiangsu I-ORG Province I-ORG No. O GDZB-019 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20180875 O BK20180873 B-AWARD and O Natural O Science O Research O in O Universities O of O Jiangsu O Province O 18KJB460005 O This O work O were O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81572707 B-AWARD and O 81772973 B-AWARD to O S O M), O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province I-ORG No.20170540256 O to O X O H), O and O Basic B-ORG Scientific I-ORG Research I-ORG Projects I-ORG of I-ORG Institutions I-ORG of I-ORG Higher I-ORG Learning I-ORG of I-ORG Liaoning I-ORG Province I-ORG LQ2017012 O to O Y O Y). O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31970196 O to O Z.L O 31570286 B-AWARD to O H.G O 31670277 B-AWARD to O K.Z O 31770318 B-AWARD to O Y.M O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2019YFA0903904 B-AWARD and O Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG KQTD20190929173906742 O to O H.G O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG 15JC1400800 O to O G.R O and O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG of I-ORG China I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG ASTIP-TRI02 O to O Y.G O This O work O was O supported O by O the O National B-ORG Basic I-ORG S&T I-ORG Resources I-ORG Survey I-ORG Project I-ORG of I-ORG China I-ORG #2017FY100602 O the O Earmarked O Fund O for O the O Modern B-ORG Agro-Industry I-ORG Technology I-ORG Research I-ORG System I-ORG #CARS-34 O to O XZ O and O the O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 I-ORG Program I-ORG #2014CB138705 O to O XM. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2016JX05 O Forestry B-ORG Public I-ORG Welfare I-ORG Projects I-ORG Special I-ORG Fund I-ORG of I-ORG China I-ORG 201304301 O and O Beijing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG Z141100006014031 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O study O was O supported O by O the O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG China I-ORG 201510010040 O China B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG 2015A030313152 O Guangdong B-ORG Provincial I-ORG Government I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2013B010404015 O 2016A040403049 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2016A030303005 O Funders O had O no O role O in O study O design O data O collection O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O State O funding O from O the O Agence B-ORG Nationale I-ORG de I-ORG la I-ORG Recherche I-ORG under O “Investissements O d’avenir” O program O ANR-10-IAHU-01 O and I-AWARD ANR-21-CE18-0066-01 O by O the O European B-ORG Research I-ORG Council I-ORG 865797 O DITSB O and O by O Fondation B-ORG pour I-ORG la I-ORG Recherche I-ORG Médicale I-ORG FRM O PLP202110014595 O This O study O was O supported O by O the O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG HH, O RP-PG-0407–10314 B-AWARD Wellcome B-ORG Trust I-ORG HH, O 086091/Z/08/Z B-AWARD and O the O Medical B-ORG Research I-ORG Council I-ORG Prognosis I-ORG Research I-ORG Strategy I-ORG PROGRESS I-ORG Partnership I-ORG HH, O G0902393/99558 B-AWARD and O by O awards O to O establish O the O Farr O Institute O of O Health O Informatics O Research O at O UCL O Partners O HH, O SD O from O the O Medical O Research O Council O Arthritis O Research O UK, O British O Heart O Foundation O Cancer O Research O UK, O Chief O Scientist O Office O Economic O and O Social O Research O Council O Engineering O and O Physical O Sciences O Research O Council O National O Institute O for O Health O Research O National O Institute O for O Social O Care O and O Health O Research O and O Wellcome O Trust O HH, O grant O MR/K006584/1 O This O study O was O carried O out O on O behalf O of O the O CArdiovascular O disease O research O using O LInked O Bespoke O studies O and O Electronic O health O Records O CALIBER O programme O GDB O is O a O member O of O the O Alzheimer O Scotland O Dementia O Research O Centre O funded O by O Alzheimer O Scotland O and O the O University O of O Edinburgh O Centre O for O Cognitive O Ageing O and O Cognitive O Epidemiology O part O of O the O cross O council O Lifelong O Health O and O Wellbeing O Initiative O G0700704 O 84698 O Funding O from O the O BBSRC O EPSRC O ESRC O and O MRC O is O gratefully O acknowledged O SD O is O supported O by O a O UCL O Provost’s O Strategic O Development O Fund O Fellowship O JG O was O funded O by O an O NIHR O Doctoral O Fellowship O DRF-2009–02–50 O MK O is O supported O by O the O Medical O Research O Council O K013351 O the O National O Heart O Lung O and O Blood O Institute O HL36310 O the O National O Institute O of O Aging O AG034454 O and O a O professorial O fellowship O from O the O Economic O and O Social O Research O Council O This O article O presents O independent O research O funded O in O part O by O the O NIHR O The O views O expressed O are O those O of O the O authors O and O not O necessarily O those O of O the O NHS O the O NIHR O or O the O Department O of O Health O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O grants O from O the O Ningxia B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2021AAC03014 O National B-ORG Key I-ORG Research I-ORG I-ORG Developmental I-ORG Program I-ORG of I-ORG Ningxia I-ORG 2021BEF02029 O National B-ORG Key I-ORG Research I-ORG I-ORG Developmental I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC1003701 O and O Institution B-ORG of I-ORG Higher I-ORG Education I-ORG Projects I-ORG of I-ORG Building I-ORG First-class I-ORG Discipline I-ORG Construction I-ORG in I-ORG Ningxia I-ORG Region I-ORG Biology O NXYLXK2017B05 O This O work O was O supported O in O part O by O grants O from O the O following O sources O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81972636 O 81872281 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG 2019JJ40175 O 2019JJ40183 B-AWARD 2018JJ1013 B-AWARD 2017JJ2210 B-AWARD the B-ORG Research I-ORG Project I-ORG of I-ORG Health I-ORG Commission I-ORG of I-ORG Hunan I-ORG Province I-ORG 20201020 O B20180400 B-AWARD B20180582 B-AWARD and O Ascend B-ORG Foundation I-ORG of I-ORG National I-ORG cancer I-ORG center I-ORG NCC2018b68 O This O work O was O supported O by O grants O from O the B-ORG National I-ORG Science I-ORG I-ORG Technology I-ORG Pillar I-ORG Program I-ORG during I-ORG the I-ORG Twelfth I-ORG Five-year I-ORG Plan I-ORG Period I-ORG 2014BAI09B10 O the B-ORG Health I-ORG I-ORG Medical I-ORG Collaborative I-ORG Innovation I-ORG Project I-ORG of I-ORG Guangzhou I-ORG City I-ORG China I-ORG 201400000001 O and O the B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Guangzhou I-ORG City I-ORG China I-ORG 14570006 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG of O Australia O APP1112681 O to I-AWARD D.J.M B-AWARD by O core O funding O from O the O European B-ORG Molecular I-ORG Biology I-ORG Laboratory I-ORG D.J.M O core O funding O from O Cancer B-ORG Research I-ORG UK I-ORG A17197 O to I-AWARD A.T.L.L O the O United B-ORG Kingdom I-ORG Medical I-ORG Research I-ORG Council I-ORG studentship O to O K.R.C B-AWARD and O the O Oxford B-ORG Single I-ORG Cell I-ORG Biology I-ORG Consortium I-ORG Q.F.W O This O work O was O financed O by O Fundação B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG a I-ORG Tecnologia O I.P O Lisbon O Portugal O in O the O scope O of O the O projects O UIDP/04378/2020 B-AWARD UIDB/04378/2020 B-AWARD and O PTDC/BTA-BTA/30902/2017 B-AWARD of O the O Research O Unit O on O Applied O Molecular O Biosciences—UCIBIO O and O the O project O LA/P/0140/2020 B-AWARD of O the O Associate B-ORG Laboratory I-ORG Institute I-ORG for I-ORG Health I-ORG and I-ORG Bioeconomy—i4HB O The O work O was O also O supported O through O the O projects O UIDB/50006/2020 B-AWARD and O UIDP/50006/2020 B-AWARD funded O by O FCT/MCTES B-ORG through O national O funds O This O research O was O partly O supported O by O Beijing B-ORG Nova I-ORG Program I-ORG xx2016120 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81101107 O 31640035 B-AWARD and O 71661167001 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Beijing I-ORG Municipality I-ORG 4162008 O and O Beijing O Municipal O Education O Commission O PXM2017_014204_500012 O This O research O was O funded O by O the O Ningbo B-ORG Public I-ORG Welfare I-ORG Key I-ORG Project I-ORG 2022S148 O the O Wenzhou B-ORG Major I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG ZN2021002 O and O the O Ningbo B-ORG “3315 I-ORG series I-ORG program” I-ORG for I-ORG high-level I-ORG talents I-ORG 2020B-34-G O This O work O was O supported O by O Medical B-ORG Research I-ORG Council O MC_U105178778 B-AWARD Dr. O Benjamin O J O Nichols O British B-ORG Heart I-ORG Foundation O PG/14/25/30726 B-AWARD Dr. O Benjamin O J O Nichols O Ministry B-ORG of I-ORG Science I-ORG Research I-ORG and I-ORG the I-ORG Arts I-ORG of I-ORG Baden-Württemberg I-ORG Az: B-AWARD 32-7533.-6-10/15/5 O Manfred O Frick O Deutsche B-ORG Forschungsgemeinschaft O Research B-AWARD training I-AWARD group I-AWARD GRK I-AWARD 2203 O Manfred O Frick O The O work O was O financially O supported O by O the O Slovenian B-ORG Research I-ORG Agency O research O core O funding O No. O P2-0412 B-AWARD and O P2-0089 B-AWARD postdoctoral B-ORG project I-ORG No. O Z2-2644 B-AWARD ARRS B-ORG project I-ORG No. O J23034 B-AWARD J2-3040 B-AWARD J2-3046 B-AWARD J3-3079 B-AWARD J7-4420 B-AWARD and O bilateral B-ORG ARRS I-ORG project I-ORG No. O BI-FR/23-24-PROTEUS-005 B-AWARD The O authors O appreciate O the O support O of O the O National B-ORG Science I-ORG Centre I-ORG Poland I-ORG within O the O programs O MAESTRO O grant O number O 2020/38/A/ST3/00214 B-AWARD SONATA O grant O numbers O 2021/43/D/ST3/01444 B-AWARD and O 2020/39/D/ST3/03000 B-AWARD and O OPUS O LAP O 2021/43/I/ST3/01357 O Work O by O W.P O and O W.A.T O at O MIT O was O supported O by O the O U.S B-ORG Department I-ORG of I-ORG Energy I-ORG Office I-ORG of I-ORG Science I-ORG Basic I-ORG Energy I-ORG Sciences O under O award O number O DE-SC0019345 B-AWARD This O study O has O been O partially O supported O through O the O EUR B-ORG grant O NanoX O no. O ANR-17-EURE-0009 B-AWARD in O the O framework O of O the O “Programme O des O Investissements O d’Avenir” O This O work O was O funded O by O the O National B-ORG Key I-ORG Technologies I-ORG R&D I-ORG Program I-ORG No. O 2015BAI13B09 B-AWARD the O Research B-ORG Foundation I-ORG of I-ORG Beijing I-ORG Friendship I-ORG Hospital I-ORG Capital I-ORG Medical I-ORG University I-ORG No. O yyqdkt2018-10 B-AWARD and O Wu B-ORG Jieping I-ORG Medical I-ORG Foundation I-ORG No. O 320.6750.19089-37 B-AWARD This O project O was O made O possible O by: O The O Center B-ORG for I-ORG Health I-ORG Effects I-ORG of I-ORG Environmental I-ORG Contamination I-ORG Seed I-ORG Grants O FY B-AWARD 2010 O the O National B-ORG Center I-ORG for I-ORG Research I-ORG Resources O a O part O of O the O National O Institutes O of O Health O NIH O UL1RR024979 B-AWARD and O KO1HL080966 B-AWARD National B-ORG Institute I-ORG of I-ORG Environmental I-ORG Health I-ORG Sciences O P30 B-AWARD ES005605 I-AWARD and O National B-ORG Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases O NO1-AI-30040-01 B-AWARD Funding O sources O did O not O participate O in O the O design O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31670772 B-AWARD 81870517 B-AWARD 81500534 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG Grant O No. O 18140900302),The B-AWARD National B-ORG Research I-ORG Foundation I-ORG for I-ORG the I-ORG Doctoral I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG of I-ORG China I-ORG No.20130142120072 O and O Innovation B-ORG Foundation I-ORG of I-ORG Huazhong I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG No.1802030 O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 51478190 B-AWARD and O 51278200 B-AWARD Guangdong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Key I-ORG Project I-ORG Grant O No. O 2014A030311014 B-AWARD and O Guangzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG Grant O No. O 201510010288 B-AWARD We O acknowledge O financial O support O from O ERC B-ORG advanced I-ORG grant I-ORG ERC-ADG-2015 O n° I-AWARD 694812–Hypoximmuno O ERC-2020-PoC O 957565-AUTO.DISTINCT O Authors O also O acknowledge O financial O support O from O the O European B-ORG Union’s I-ORG Horizon I-ORG 2020 I-ORG Research I-ORG and I-ORG Innovation I-ORG Programme I-ORG under O the O following O grant O agreements O ImmunoSABR B-AWARD n° I-AWARD 733008 O MSCA-ITN-PREDICT B-AWARD n° I-AWARD 766276 O CHAIMELEON B-AWARD n° I-AWARD 952172 O EuCanImage B-AWARD n° I-AWARD 952103 O JTI-IMI2-2020-23-two-stage B-AWARD IMI-OPTIMA I-AWARD n° I-AWARD 101034347 O and O TRANSCAN B-ORG Joint I-ORG Transnational I-ORG Call I-ORG 2016 I-ORG JTC2016 O CLEARLY I-AWARD n° I-AWARD UM I-AWARD 2017-8295 O This O work O was O supported O by O the O Dutch B-ORG Cancer I-ORG Society I-ORG KWF O Kankerbestrijding O Project O number O 14449/2021-PoC B-AWARD This O study O has O received O funding O from O the O China B-ORG Scholarship I-ORG Council I-ORG No. O 202006675008 B-AWARD This O work O was O supported O by O the O Guangxi B-ORG Zhuang I-ORG Autonomous I-ORG Region I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG Foundation I-ORG Z2016627 O Key B-ORG R&D I-ORG Program I-ORG of I-ORG Guangxi I-ORG Zhuang I-ORG Autonomous I-ORG Region I-ORG AB16380229 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81260121 O The O funders O had O no O role O in O study O design O collection O analysis O interpretation O of O data O writing O the O report O nor O in O the O decision O to O submit O the O report O for O publication O This O work O was O supported O by O the O Generalitat B-ORG de I-ORG Catalunya I-ORG 2017-SGR-292 O H2020 B-ORG Marie I-ORG Skłodowska-Curie I-ORG Actions I-ORG ITN/ETN O I-AWARD 642642 O Spanish B-ORG Government I-ORG MAT2017-86357-C3-1-R O associated B-AWARD FEDER O The O project O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Project O No. O 31872511 B-AWARD and O in O part O by O the O Applied B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG Sichuan I-ORG Province I-ORG Project O No. O 2021YJ0289 B-AWARD and O in O part O by O the O Initial B-ORG Foundation I-ORG of I-ORG Scientific I-ORG Research I-ORG for I-ORG the I-ORG Introduction I-ORG of I-ORG Talents I-ORG Project O No. O RQD2021075 B-AWARD This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81801444 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Province I-ORG 1808085QH267 O and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG WK9110000049 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 31472194 B-AWARD 31272530 B-AWARD 31172291 B-AWARD the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Nos O 2016YFD0500102 B-AWARD 2016YFD0500707 B-AWARD and O the O Youth B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Jilin I-ORG Province I-ORG No. O 20160520033JH B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFA0506100 O the B-ORG International I-ORG Joint I-ORG Research I-ORG Grant I-ORG of I-ORG Fujian I-ORG Agriculture I-ORG and I-ORG Forestry I-ORG University I-ORG KXGH170102 O the B-ORG National I-ORG Science I-ORG Foundation I-ORG Grant I-ORG 31870170 O and O the O Fok O Ying O Tung O Education O Foundation O 161027 O to O Xu O Chen O The O funding O bodies O did O not O play O any O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O L.P O was O supported O by O the O FNS B-ORG project I-ORG REEFISH I-ORG no. O 310030E-164294 B-AWARD J.C.S O was O supported O by O the O European B-ORG Research I-ORG Council I-ORG ERC-2012-StG-310886-HISTFUNC O and O also O considers O this O work O a O contribution O to O his O VILLUM O Investigator O project O ‘Biodiversity O Dynamics O in O a O Changing O World’ O funded O by O VILLUM B-ORG FONDEN I-ORG grant O no. O 16549 B-AWARD N.E.Z O was O supported O by O the O SNSF B-ORG grants O 31003A_149508/1 B-AWARD and I-AWARD 310030L_170059 I-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 31901690 B-AWARD the O Scientific O Research O Fund O Project O of O Department B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Sichuan I-ORG Province I-ORG grant O number O 2018JY0149 B-AWARD and O the O Scientific O Research O Foundation O of O Sichuan B-ORG Agricultural I-ORG University I-ORG grant O number O 03120321 B-AWARD This O study O was O supported O by O grants O from O the B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Guangzhou I-ORG city O no. O 201707010387 B-AWARD the B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG no. O 2014A020212626 B-AWARD the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O China O No: O 2016A030313575 B-AWARD and O the B-ORG National I-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 81501677 B-AWARD No: O 81772095 B-AWARD The O funding O bodies O had O no O involvement O in O the O design O of O the O study O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81830005 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2019YFA0110204 O and O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG CIFMS O 2016-I2M-1-007 O The O HAPO O study O was O funded O by O the O National B-ORG Institute I-ORG of I-ORG Child I-ORG Health I-ORG and I-ORG Human I-ORG Development I-ORG grant O no. O R01-HD34242 B-AWARD and O the O National B-ORG Institute I-ORG of I-ORG Diabetes I-ORG and I-ORG Digestive I-ORG and I-ORG Kidney I-ORG Diseases I-ORG grant O no. O R01-HD34243 B-AWARD The O HAPO O follow-up O study O at O the O Hong O Kong O Center O was O supported O by O the O funding O from O the O General B-ORG Research I-ORG Fund I-ORG of I-ORG the I-ORG Research I-ORG Grants I-ORG Council I-ORG of I-ORG the I-ORG Hong I-ORG Kong I-ORG SAR I-ORG China I-ORG grants O CUHK B-AWARD 473408 I-AWARD and O in O part O CUHK O 471713 O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG MOP-133458 O University B-ORG of I-ORG Saskatchewan I-ORG College O of O Medicine O Bridge O Funding O CoMBRIDGE O Natural B-ORG Sciences I-ORG and I-ORG Engineering I-ORG Research I-ORG Council I-ORG of I-ORG Canada I-ORG RGPIN-2018-06335 O Canadian O Network O on O Hepatitis O C O CanHepC O Training O Program O Doctoral O Research O Fellowships O to O R.K O Natural O Sciences O and O Engineering O Research O council O of O Canada O Undergraduate O Summer O Research O Awards O NSERC-USRA O to O S.G O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 31871111 B-AWARD Youth B-ORG Innovation I-ORG Promotion I-ORG Association I-ORG CAS O grant O number O 2020088 B-AWARD the O Scientific B-ORG and I-ORG Technological I-ORG Innovation I-ORG Programs I-ORG of I-ORG Higher I-ORG Education I-ORG Institutions I-ORG in I-ORG Shanxi O grant O number O 2022L341 B-AWARD and O the O Basic B-ORG Research I-ORG Fund I-ORG of I-ORG People’s I-ORG Public I-ORG Security I-ORG University I-ORG of I-ORG China O grant O number O 2016JKF01314 B-AWARD Research O operating O funding O was O provided O by O the O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG Grant O O 101051 B-AWARD Saskatchewan B-ORG Health I-ORG Research I-ORG Foundation I-ORG Grant O O 2776 B-AWARD Western B-ORG College I-ORG of I-ORG Veterinary I-ORG Medicine I-ORG Research I-ORG Trust I-ORG Grant O O 417785 B-AWARD Infrastructure O funding O was O provided O by O the O Canada B-ORG Foundation I-ORG for I-ORG Innovation I-ORG John O R. O Evans O Leaders O Fund O Project O O 32512 B-AWARD The O funding O agencies O had O no O roles O in O study O design O data O collection O and O analysis O data O interpretation O or O writing O of O the O manuscript O This O study O was O supported O by O the B-ORG funding I-ORG from I-ORG the I-ORG Open I-ORG Project I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Key I-ORG Laboratory I-ORG of I-ORG Zoonosis I-ORG R1507 O A B-ORG Project I-ORG Funded I-ORG by I-ORG the I-ORG Priority I-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O and O the B-ORG University I-ORG Graduate I-ORG Scientific I-ORG Research I-ORG Innovation I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG CXLX_1431 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O European B-ORG Commission’s O Horizon O 2020 O research O and O innovation O programme O under O the O Marie O Skłodowska-Curie O MSCA O grant O agreement O No O 956481 B-AWARD through O the O RASOPTA O Ph.D O fellowship O M.T O was O supported O through O “Plan O Nacional I-ORG de I-ORG Investigación” O with O reference O PID2020-113221RB-I00 B-AWARD and O a O Ramon B-ORG y I-ORG Cajal I-ORG contract I-ORG with O reference O RYC2019-026841-I B-AWARD L.T O was O supported O by O the O “Agencia O Estatal I-ORG de I-ORG Investigación” O with O a O “Plan O Nacional O de O Investigación” O with O reference O PID2020-117557RB-C21 B-AWARD This O work O was O supported O by O the O Commission B-ORG of I-ORG the I-ORG European I-ORG Communities I-ORG Fifth I-ORG Framework I-ORG Programme I-ORG ‘Quality O of O Life O and O Management O of O Living O Resources’ O grant O number O QLK6-CT-2001-00258 B-AWARD Arthritis B-ORG Research I-ORG UK I-ORG grant O number O 20380 B-AWARD and O the O UK O National B-ORG Osteoporosis I-ORG Society I-ORG grant O number O 120/152 B-AWARD This O report O includes O independent O research O supported O by O the O National O Institute O for O Health O Research O Biomedical O Research O Unit O Funding O Scheme O The O views O expressed O in O this O publication O are O those O of O the O author(s O and O not O necessarily O those O of O the O NHS O the O National O Institute O for O Health O Research O or O the O Department O of O Health O The O pQCT O measurements O were O funded O through O a O research O grant O from O Central O Manchester O Universities O Hospitals O NHS O Foundation O Trust O Endowment O Funds O Dr. O K.A.W O is O supported O by O the O Nutrition O and O Bone O Health O Core O Program O at O MRC O Human O Nutrition O Research O funded O by O the O UK O Medical O Research O Council O grant O number O U10596037 O The O financial O sponsors O played O no O role O in O the O design O execution O analysis O and O interpretation O of O data O or O writing O of O this O study O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2021YFD1601002 B-AWARD the O Central B-ORG Guidance I-ORG on I-ORG Local I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Fund I-ORG of I-ORG Guizhou I-ORG Province I-ORG Grant O No. O 2022]4038 B-AWARD the O Youth B-ORG Fund I-ORG of I-ORG Guizhou I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG Grant O No. O 2021]21 B-AWARD and O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guizhou I-ORG Province(Grant O No. O 2020]4008 B-AWARD 2022]key023 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O under O Grant O Nos O 61731014 B-AWARD 61671316 B-AWARD and O 61601319 B-AWARD the O Research O Project O Supported O by O Shanxi O Scholarship O Council O of O China O under O Grant O No. O 2017-key-2 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanxi I-ORG Province I-ORG under O Grant O No. O 201801D121145 B-AWARD and O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG of I-ORG Shanxi I-ORG Province I-ORG under O Grant O No. O 201703D321037 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O No. O U21A2009 B-AWARD Natural O Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province O grant O number O 2018JJ2162 O and O the O State B-ORG Scholarship I-ORG Found I-ORG of I-ORG China I-ORG Scholarship I-ORG Council I-ORG CSC O grant O number O No: O 2016-3035 O This O research O was O funded O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2017YFF0204802 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 51775380 B-AWARD 51835007 B-AWARD 51721003 B-AWARD and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Tianjin I-ORG Grant O No. O 18JCYBJC19400 B-AWARD This O research O was O supported O by O a O grant O from O the O National B-ORG Institutes I-ORG of I-ORG Health/National O Institute I-ORG on I-ORG Aging I-ORG R01 O AG008235 O to O RAD O who O also O acknowledges O support O from O the O Canada O Research O Chairs O program O SWSM O was O supported O by O grants O from O the O National O Institutes O of O Health/National O Institute O on O Aging O R21 O AG045575 O and O the O Natural B-ORG Sciences I-ORG and I-ORG Engineering I-ORG Research I-ORG Council I-ORG of I-ORG Canada I-ORG 418676-2012 O This O research O was O funded O by O Grant O Number O R21TR001722 B-AWARD from O the O National B-ORG Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences I-ORG NCATS O Grant O Number O R01LM011986 B-AWARD from O the O National B-ORG Library I-ORG of I-ORG Medicine I-ORG NLM O and O Grant O Number O R01GM122845 B-AWARD from O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG NIGMS O of O the O National O Institute O of O Health O NIH O This O study O was O supported O by O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III I-ORG CIBERobn O under O Grant O CB12/03/30007 B-AWARD The O Basque B-ORG Government I-ORG under O Grant O IT1482-22 B-AWARD and O Synergic O R&D O Projects O in O New O and O Emerging O Scientific O Areas O on O the O Frontier O of O Science O and O Interdisciplinary O Nature O of O The B-ORG Community I-ORG of I-ORG Madrid I-ORG METAINFLAMATIONY2020/BIO-6600 O Laura O Isabel O Arellano-García O is O a O recipient O of O a O doctoral O fellowship O from O the O Gobierno O Vasco O This O work O was O funded O by O the O University B-ORG of I-ORG Vigo O grants O C11 B-AWARD and O ABH1-V231 B-AWARD Xunta B-ORG de I-ORG Galicia I-ORG Cluster O of O Agricultural O Research O and O Development—CITACA O Strategic O Partnership O grant O ED431E B-AWARD 2018/07 O the B-ORG “Network I-ORG for I-ORG the I-ORG Sustainable I-ORG Use I-ORG of I-ORG Natural I-ORG and I-ORG Agrifood I-ORG Resources” I-ORG REDUSO O grant O ED431D B-AWARD 2017/18 O and O PT B-ORG national I-ORG funds I-ORG FCT/MCTES O Fundação O para O a O Ciência O e O Tecnologia O and O Ministério O da O Ciência O Tecnologia O e O Ensino O Superior O through O projects O UIDB/50006/2020 B-AWARD and O UIDP/50006/2020 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51905388 O 51875416 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M632928 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG 2019CFB111 O and O the O Open O Fund O of O Hubei O Key O Laboratory O of O Mechanical O Transmission O and O Manufacturing O Engineering O 2018A08 O This O study O was O supported O by O The B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Chinahttp://www.most.gov.cn/(2017YFC0306600 O Sanya O Key O Laboratory O Programhttp://zwzx.sanya.gov.cn/(L1501 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Chinahttp://www.nsfc.gov.cn/(41576127 O Hundred B-ORG Talents I-ORG Program I-ORG of I-ORG CAShttp://www.cas.cn/(SIDSSE–BR–201401 O received O by O HZ. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O grants O from O Youth B-ORG Talents I-ORG Training I-ORG Program I-ORG of I-ORG Shandong I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG SAAS-YTTP-2014 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31371255 O 31271328 B-AWARD 31401049 B-AWARD and O the O Cow B-ORG Innovation I-ORG Team I-ORG of I-ORG the I-ORG Shandong I-ORG Province I-ORG Modern I-ORG Agricultural I-ORG Industry I-ORG Technology I-ORG System I-ORG SDAIT-12-011-02 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O SPIRITS B-AWARD Supporting O Program O for O Interaction-based O Initiative O Team O Studies O to O M.K O from O Kyoto B-ORG University I-ORG http://research.kyoto-u.ac.jp/service/topic/spirits/lists/h26list/sprits_h26ja_kumeta O the O Advanced O Research O O Development O Programs O for O Medical O Innovation O from O the O Japan B-ORG Agency I-ORG for I-ORG Medical I-ORG Research I-ORG and I-ORG Development I-ORG No. O 16gm5810018h0001 B-AWARD to O S.H.Y O http://www.amed.go.jp/koubo/010720160323_kettei_kadai02.html O and O KAKENHI O Challenging O Research O Exploratory O No. O JP17K19394 B-AWARD to O M.K O from O Japan B-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 61971026 B-AWARD 81871505 B-AWARD This O work O was O sponsored O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Beijing I-ORG Municipality I-ORG 4202053 O and O Beijing B-ORG University I-ORG of I-ORG Chemical I-ORG Technology I-ORG Grant O Nos O buctrc201905 B-AWARD buctylkjcx06 B-AWARD This O work O was O also O funded O by O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG XK1802-4 O PYBZ1830 B-AWARD This O research O was O funded O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 81974540 B-AWARD 82274290 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Grant O No. O 2023-JC-QN-0257 B-AWARD Key B-ORG Research I-ORG I-ORG Development I-ORG Program I-ORG of I-ORG Shaanxi I-ORG Program O No. O 2022ZDLSF02-09 B-AWARD and O the O Innovation B-ORG Capability I-ORG Support I-ORG Program I-ORG of I-ORG Shaanxi I-ORG Program O No. O 2021TD-58 B-AWARD This O work O was O supported O by O the B-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2023NSFSC1987 O and O in O part O by O the B-ORG Postgraduate I-ORG Innovation I-ORG Fund I-ORG Project I-ORG of I-ORG Sichuan I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Engineering I-ORG under O grant O Y2022147 B-AWARD and O the B-ORG Artificial I-ORG Intelligence I-ORG Key I-ORG Laboratory I-ORG of I-ORG Sichuan I-ORG Province I-ORG grant O number O 2019RZJ04 B-AWARD Development O of O research O in O this O article O was O supported O by O the O financing O provided O to O the O Mexican O National O Institute O of O Public O Health O Spanish O acronym O INSP O by O Sanofi B-ORG under O registration O number O DIREGL07857 B-AWARD S.B O the O Fogarty B-ORG International I-ORG Center I-ORG of O the O National O Institutes O of O Health O http://www.fic.nih.gov/Pages/Default.aspx O under O Award O Number O R03TW009061 B-AWARD S.B O A.P.-T O Also O is O supported O in O part O by O the O Robert B-ORG Wood I-ORG Johnson I-ORG Foundation I-ORG grant O under O Award O Number O 74155 B-AWARD C.H.-A O K.M.-H O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81770152 B-AWARD and O 91642111 B-AWARD the O Guangdong B-ORG Provincial I-ORG Applied I-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG I-ORG Development I-ORG Program I-ORG No. O 2016B020237006 B-AWARD and O the O Guangzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG Nos O 201510010211 B-AWARD 20180710004 B-AWARD and O 201803040017 B-AWARD The O current O research O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Number O 31800477 B-AWARD the O Anhui B-ORG Provincial I-ORG National I-ORG Science I-ORG Foundation I-ORG Grant O Numbers O 1808085MC69 B-AWARD the O Anhui B-ORG Agricultural I-ORG University I-ORG Provincial I-ORG Innovation I-ORG fund I-ORG Grant O Number O 201910364259 B-AWARD and O the O Anhui B-ORG Agricultural I-ORG University I-ORG Innovation I-ORG Foundation I-ORG for I-ORG Postgraduate I-ORG under O Grant O Numbers O 2019ysj-15 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC20160905200 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81600824 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2016A030310220 O 2018A030310278 B-AWARD 2015A030313880 B-AWARD Young B-ORG Teachers I-ORG Training I-ORG Program I-ORG of I-ORG Sun I-ORG Yat-sen I-ORG University I-ORG 16ykpy46 O 17ykpy73 B-AWARD Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG 201707010106 O 201804010459 B-AWARD and O the O Young B-ORG Elite I-ORG Scientist I-ORG Sponsorship I-ORG Program I-ORG by I-ORG CAST I-ORG 2016QNRC001 O The O study O performance O was O financially O supported O by O HiPP O GmbH O O Co. O Vertrieb O KG O Pfaffenhofen O Germany O who O supplied O the O respective O formulae O during O the O intervention O period O and O provided O support O in O the O form O of O salaries O for O the O authors O BK, O MF, O HD, O VG O but O did O not O have O any O additional O role O in O the O data O analysis O decision O to O publish O or O preparation O of O the O manuscript O MF O carried O out O analyses O while O she O was O employed O at O the O Dr. O von O Hauner O Children’s O Hospital O Munich O Div O of O Metabolic O and O Nutritional O Medicine O She O is O now O an O employee O of O HiPP O GmbH O O Co. O Vertrieb O KG. O BT O is O an O employee O of O HiPP O GmbH O O Co. O Vertrieb O KG. O Furthermore O the O authors’ O work O is O financially O supported O in O part O by O the O Commission O of O the O European O Communities O Early B-ORG Nutrition I-ORG Projects O FP7-289346 O DYNAHEALTH B-ORG H2020-633595 O and O LIFECYCLE B-ORG H2020-SC1-2016-RTD O and O the O European O Research O Council O Advanced O Grant O META-GROWTH B-ORG ERC-2012-AdG O 322605 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grants O 61772176 B-AWARD 61402153 B-AWARD and O 61370169 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O 2016M602247 B-AWARD the O Plan O for O Scientific O Innovation O Talent O of O Henan O Province O Grant O 184100510003 O the O Key O Scientific O and O Technological O Project O of O Henan O Province O Grant O 182102210362 O the O Young O Scholar O Program O of O Henan O Province O Grant O 2017GGJS041 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Henan I-ORG Province I-ORG Grants O 182300410130 B-AWARD 182300410368 B-AWARD and O 182300410306 O and O the O Ph.D O Research O Foundation O of O Henan O Normal O University O Grant O qd15132 O TheStrategic O Research I-ORG Programme I-ORG in I-ORG Diabetes I-ORG at I-ORG Karolinska I-ORG Institutet(Swedish O Research O Council O grant O No O 2009-1068 B-AWARD Sweden;European O Research I-ORG Council(ICEBERG O ERC-2009-AdG233285),European B-AWARD Union I-ORG Swedish I-ORG Research I-ORG CouncilDistinguished O Professor O Award O 2015-00165 O Sweden;The O Swedish I-ORG Diabetes I-ORG Foundation(DIA2015-052 O Sweden;Swedish O Foundation I-ORG for I-ORG Strategic I-ORG Research(SRL10-0027 O Sweden;Diabetes O Wellness I-ORG Network(783_2015PG O Sweden;Novo O Nordisk I-ORG Foundation(NNF14OC0011493 O NNF17OC0030088 B-AWARD and O NNF14OC0009941 B-AWARD Denmark O andStockholm O County I-ORG Council(20150326 O Sweden O supported O this O research O This O work O was O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG No. O 2017J01567 B-AWARD Science B-ORG Foundation I-ORG of I-ORG the I-ORG Education I-ORG Department I-ORG of I-ORG Fujian I-ORG Province I-ORG No. O JA15476 B-AWARD and O the B-ORG Program I-ORG for I-ORG Fujian I-ORG Normal I-ORG University I-ORG Innovation I-ORG Team I-ORG “Probability I-ORG and I-ORG Statistics I-ORG Theory I-ORG and I-ORG Application” I-ORG No. O IRTL1704 B-AWARD This O work O was O supported O in O part O by O grants O from O the O Beijing B-ORG Municipal I-ORG National I-ORG Science I-ORG Foundation I-ORG No. O 6172014 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31401873 B-AWARD Beijing B-ORG Municipal I-ORG Department I-ORG of I-ORG Organization I-ORG 2016000021223ZK22 O National B-ORG Key I-ORG Technology I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2015BAD02B00 O 2014BAD01B09 I-AWARD and I-AWARD 2012BAD02B03 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0100204 O 2017YFD0102000 O Beijing B-ORG Municipal I-ORG Science I-ORG I-ORG Technology I-ORG Commission I-ORG D171100002517001 O Seed B-ORG Bureau I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Agriculture I-ORG China I-ORG 11162130109236051 O and O Beijing B-ORG Academy I-ORG of I-ORG Agricultural I-ORG and I-ORG Forestry I-ORG Sciences I-ORG QNJJ201501 O KJCX20161503 I-AWARD KJCX2017102 I-AWARD KJCX20170402 I-AWARD JNKYT201601 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National O Key O R&D O Program O of O China O Project O No. O 2017YFC0703000 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Project O Nos O 51778102 B-AWARD and I-AWARD 51978126 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Project O No. O DUT18LK35 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province I-ORG of O China O Project O No. O 20180550763 B-AWARD This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81471295 O and O No.81671075 O to O Lu O Shen O No.81701134 O to O Bin O Jiao O the O National B-ORG Key I-ORG Plan I-ORG for I-ORG Scientific I-ORG Research I-ORG and I-ORG Development I-ORG of I-ORG China I-ORG No.2016YFC1306000 O to O Beisha O Tang O the O Xiangya B-ORG Hospital I-ORG Youth I-ORG Scientific I-ORG Research I-ORG Fund I-ORG No.2016Q01 O to O Bin O Jiao O This O work O was O funded O by O the O Rongxiang B-ORG Regenerative I-ORG Medicine I-ORG Foundation I-ORG of I-ORG Shandong I-ORG University I-ORG 2019SDRX-17 O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 82071470 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2020MH278 O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31571822 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O BK20160493 B-AWARD the O Social O Development O Project O of O Jiangsu O Province O No. O BE2017683 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2015M571691 B-AWARD the O Senior O Talent O Scientific O Research O Initial O Funding O Project O of O Jiangsu O University O No. O 15JDG17 O O 15JDG061 O the O 2015 O International O Postdoctoral O Exchange O Fellowship O Program O of O China O the O 2014 O Excellent O Key O Young O Teachers O Project O of O Jiangsu O University O and O the O Qing O Lan O Project O of O Jiangsu O Province O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O No. O 31700338 B-AWARD and O 31860118 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG 1610322019012 O and O 1610322019013 B-AWARD and O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG CAASASTIP-2019-LIHPS-08 O The O funding O bodies O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O in O writing O the O manuscript O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG China I-ORG No. O 81471670 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2014M560791 B-AWARD 2015T81037 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG China I-ORG No. O 2014qngz-04 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Plan I-ORG of I-ORG Innovation I-ORG Project I-ORG Shaanxi I-ORG province I-ORG China I-ORG No. O 2015KTCL03-06 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Ministerio B-ORG de I-ORG Ciencia I-ORG e I-ORG Innovación O Spain O http://www.idi.mineco O gob.es O and O European O Regional O Development O fund O http://ec.europa.eu/regional_policy/en/funding/erdf O Grant O BIO2010-17853 B-AWARD awarded O to O FG; O Ministerio B-ORG de I-ORG Economía I-ORG y I-ORG Competitividad O Spain O http://www.idi.mineco.gob.es O and O European O Regional O Development O fund O http://ec.europa.eu/regional_policy/en/funding/erdf O Grant O BIO2013-420173-P B-AWARD awarded O to O FG; O and O Consejo B-ORG Superior I-ORG de I-ORG Investigaciones I-ORG Científicas O Spain O http://www.csic.es O JAE-Predoc B-AWARD 2010 I-AWARD scholarship O awarded O to O AJ-F O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O Ministry B-ORG of I-ORG Economy I-ORG Industry I-ORG and I-ORG Competitiveness O SAF201679311-R B-AWARD to O MDP O Spanish B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Innovation O PID2019-108659RB-I00 B-AWARD to O AMM O UCLM/ERDF B-ORG 2020-GRIN-29101 B-AWARD 2021-GRIN-30974 B-AWARD to O MDP O 2020-GRIN-29145 B-AWARD 2022-GRIN-34200 B-AWARD to O AMM O Autonomous B-ORG Government I-ORG of I-ORG Castilla-La I-ORG Mancha/ERDF O SBPLY/21/180501/000093 B-AWARD to O AMM O and O IUB O This O study O was O supported O by O grant O No. O 81771323 B-AWARD of O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O No. O A2019488 B-AWARD of O Medical B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG of I-ORG China O and O grant O No. O 201849 B-AWARD of O Scientific B-ORG Research I-ORG Project I-ORG of I-ORG Pingshan I-ORG District I-ORG Health I-ORG System I-ORG of I-ORG Shenzhen I-ORG City I-ORG This O work O was O supported O by O the O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31872804 O 31701064 B-AWARD National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0201300 O and O Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG 2018JZ0060 O to O Dr. O Kai O Shu O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81372894 B-AWARD 81072198 B-AWARD 81272182 B-AWARD Hunan B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 10JJ6035 B-AWARD the B-ORG Key I-ORG Project I-ORG of I-ORG Hunan I-ORG Provincial I-ORG Education I-ORG Department I-ORG No. O 10A104 B-AWARD 16K077 B-AWARD and O the O construct O program O of O the O key O discipline O in O Hunan O Province O China O Basic O Medicine O Sciences O in O University O of O South O China O This O research O was O funded O by O the O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O Postgraduate B-ORG Research I-ORG I-ORG Practice I-ORG Innovation I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province O grant O numbers O SJCX22_1657 B-AWARD Postgraduate B-ORG Research I-ORG I-ORG Practice I-ORG Innovation I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Ocean I-ORG University O grant O numbers O KYCX2022-29 B-AWARD and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 62071207 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Any O authors O did O not O receive O a O salary O from O any O of O the O funders O This O study O was O financially O supported O by O grant O PICT-2016-3721 B-AWARD I-AWARD Préstamo I-AWARD BID I-AWARD from O Agencia B-ORG Nacional I-ORG de I-ORG Promoción I-ORG Científica I-ORG y I-ORG Tecnológica I-ORG to O REV O and O AAB O REV O AAB O LBG O and O ENS O were O supported O by O Facultad O de O Ciencias O Exactas O Químicas O y O Naturales O Universidad B-ORG Nacional I-ORG de I-ORG Misiones I-ORG Proyecto O de I-AWARD Investigación I-AWARD 16Q634 O REV O AR O and O AAB O were O supported O by O Facultad O de O Ciencias O Naturales O y O Museo O Universidad B-ORG Nacional I-ORG de I-ORG La I-ORG Plata I-ORG Proyecto O Nacional I-AWARD de I-AWARD Incentivos I-AWARD Docentes I-AWARD N870 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81800858 O the B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Committee I-ORG of I-ORG Shenzhen I-ORG Grant O no. O JCYJ20210324125614039 B-AWARD the B-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG the I-ORG Chinese I-ORG Medicine I-ORG Education I-ORG Association I-ORG 2022KTM028 O the B-ORG Shenzhen I-ORG Fund I-ORG for I-ORG Guangdong I-ORG Provincial I-ORG High-level I-ORG Clinical I-ORG Key I-ORG Specialties I-ORG SZGSP014 O and O the B-ORG Sanming I-ORG Project I-ORG of I-ORG Medicine I-ORG in I-ORG Shenzhen I-ORG SZSM202011015 O National B-ORG Cancer I-ORG Institute I-ORG NCI O grant O O R00207736 B-AWARD FKT O QJ, O DHL O American B-ORG Cancer I-ORG Society I-ORG Research I-ORG Scholar I-ORG Grant O O RSG2012401CCE B-AWARD FKT O NS O National B-ORG Cancer I-ORG Institute I-ORG Cancer I-ORG Center I-ORG support O grant O P30 O CA016058 I-AWARD FKT O XM, O SKC O The O WHI O program O is O funded O by O the O National B-ORG Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute I-ORG NHLBI I-ORG National I-ORG Institutes I-ORG of I-ORG Health I-ORG U.S I-ORG Department I-ORG of I-ORG Health I-ORG and I-ORG Human I-ORG Services I-ORG through O contracts O 75N92021D00001 B-AWARD 75N92021D00002 B-AWARD 75N92021D00003 B-AWARD 75N92021D00004 B-AWARD 75N92021D00005 B-AWARD Metabolomic O analysis O in O the O WHI O was O funded O by O the O NHLBI O through O contract O HHSN268201300008C B-AWARD This O work O was O supported O by O a O grant O from O National B-ORG Key I-ORG Technology I-ORG Support I-ORG Program I-ORG 2014BAD13B03 O to O YLW O Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG 2019YFH0035 O to O MFJ O and O The O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31172198 O to O MFJ O The O funders O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O project O was O supported O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81801019 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M640929 O and O Sichuan O Science O and O Technology O Program O 2019JDRC0099 O to O X.Y O and O National B-ORG Institutes I-ORG of I-ORG Health I-ORG DE O 024000 O to O J.B.B O and O J.A.H O In O addition O funds O from O Nobel B-ORG Biocare I-ORG Services I-ORG AG I-ORG Kloten O Switzerland O were O used O to O support O this O research O 2015-1400 O This O reports O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO. O 81390083 B-AWARD Natural B-ORG Science I-ORG Youth I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Province I-ORG No. O 20171BAB215054 B-AWARD and O Key B-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Jiangxi I-ORG Province I-ORG No. O 20071BBG70049 B-AWARD This O work O was O supported O by O the O China B-ORG National I-ORG Center I-ORG for I-ORG Biotechnology I-ORG Development I-ORG 2020YFC0843800 O the O National O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81788101 O 81922028 B-AWARD and O the O Youth B-ORG Innovation I-ORG Promotion I-ORG Association I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG 2019442 O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31570681 O and O 31800574 B-AWARD CR, O the O funder O of O NSF O 31570681 O conceived O this O study O JD, O the O funder O of O NSF O 31800574 O Dalian B-ORG Minzu I-ORG University I-ORG Doctor I-ORG Scientific I-ORG Research I-ORG Foundation I-ORG 0701110152 O and O University B-ORG Innovation I-ORG Groups I-ORG Foundation I-ORG of I-ORG Dalian I-ORG 201865 O performed O the O experiments O and O wrote O the O manuscript O This O study O was O funded O by O the O National B-ORG Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases I-ORG to O JS O AI110638 O and I-AWARD AI130889 O the O U.S B-ORG Department I-ORG of I-ORG Energy I-ORG to O BRU O DESC0015662 O and O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG to O CEC O GMS O GM104603 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O European B-ORG Union’s I-ORG Horizon I-ORG 2020 I-ORG research I-ORG and I-ORG innovation I-ORG programme I-ORG under I-ORG the I-ORG Marie I-ORG Skłodowska-Curie I-ORG Grant I-ORG Agreement I-ORG No. O 812660 B-AWARD DohART-NET O for O B.S O and O T.F O the O Friedrich B-ORG Bauer I-ORG Foundation I-ORG Reg O Nr-28/21 O for O P.S O as O well O as O by O the O German B-ORG Center I-ORG for I-ORG Cardiovascular I-ORG Research I-ORG DZHK81Z0600207 O to O D.M O and O P.S O and O the B-ORG Dutch I-ORG CardioVascular I-ORG Alliance I-ORG An I-ORG initiative I-ORG with I-ORG support I-ORG of I-ORG the I-ORG Dutch I-ORG Heart I-ORG Foundation I-ORG Grants O 2020B008 B-AWARD RECONNEXT I-AWARD to O D.M O This O research O was O funded O by O the O Project O of O Sustainable B-ORG Utilization I-ORG of I-ORG Famous I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG Resources I-ORG grant O no. O 2060302 B-AWARD The O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG 2017YFC1701600 O and O National B-ORG project I-ORG cultivation I-ORG fund I-ORG of I-ORG Anhui I-ORG University I-ORG of I-ORG Chinese I-ORG Medicine I-ORG 2020py02 O provided O experimental O support O Publication O costs O were O supported O by O the O Natural B-ORG Science I-ORG Research I-ORG Grant I-ORG of I-ORG Higher I-ORG Education I-ORG of I-ORG Anhui I-ORG Province I-ORG KJ2018ZD028 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O by O the O Special B-ORG Fund I-ORG for I-ORG Forest I-ORG Scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Welfare I-ORG no. O 201504401 B-AWARD the O National B-ORG Science I-ORG I-ORG Technology I-ORG Pillar I-ORG Program I-ORG no. O 2015BAC05B01 B-AWARD Sichuan B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG no. O 2016FZ0042 B-AWARD and O the O Composition B-ORG and I-ORG Characteristics I-ORG of I-ORG Biological I-ORG Soil I-ORG Crusts I-ORG in I-ORG the I-ORG Alpine I-ORG Sand I-ORG Dunes I-ORG on I-ORG the I-ORG Northwest I-ORG of I-ORG Sichuan I-ORG no. O 2019CZZX24 B-AWARD This O study O is O partly O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81972324 B-AWARD the O China B-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG Grant O No. O 2016-I2M-3-019 B-AWARD and O by O the O non-profit B-ORG Central I-ORG Research I-ORG Institute I-ORG Fund I-ORG of I-ORG Chinese I-ORG of I-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG grant O no.2018PT32014 O This O work O was O supported O by O National B-ORG Institute I-ORG on I-ORG Aging I-ORG NIA O Contracts B-AWARD N01-AG-6–2101 I-AWARD N01-AG-6–2103 I-AWARD and I-AWARD N01-AG-6–2106 O National O Institute O on O Aging O NIA O Grant B-AWARD R01-AG028050 O and O National B-ORG Institute I-ORG of I-ORG Nursing I-ORG Research I-ORG Grant B-AWARD R01-NR012459 O This O work O was O also O supported O in O part O by O the O Intramural B-AWARD Research I-AWARD Program I-AWARD of O the O National O Institutes O of O Health O NIA O MMM O is O supported O by O the O Epidemiology O of O Aging O training O grant O at O the O University O of O Pittsburgh O NIA O T32-AG0001810 B-AWARD RAM O is O supported O through O the O Canadian B-ORG Cancer I-ORG Society I-ORG grant O 704735 O This O work O constitutes O PhD O research O funded O by O the O UK O Economic B-ORG and I-ORG Social I-ORG Research I-ORG Council I-ORG ESRC O +4 O PhD I-AWARD Studentship O The O study O was O supported O by O the O Bill O O Melinda O Gates O Foundation O grants O to O the O ALPHA B-ORG Network I-ORG OPP1082114 O the O MeSH B-ORG Consortium I-ORG OPP1120138 O and O the O HIV B-ORG Modelling I-ORG Consortium I-ORG OPP1084364 O The O Kisesa O HDSS O is O a O member O of O the O INDEPTH O Network O and O has O received O funding O from O the O Global B-ORG Fund I-ORG to O Fight O AIDS O Tuberculosis O and O Malaria O TNZ-405-GO4-H O TNZ-911-G14-S O canSAR O is O funded O by O the O Cancer B-ORG Research I-ORG UK I-ORG Drug O Discovery O Committee O strategic O award O ‘canSAR O enhancing O the O drug O discovery O knowledgebase’ O C35696/A23187 O Paul O Workman O and O Bissan O Al-Lazikani O are O funded O by O the O Institute O of O Cancer O Research O Costas O Mitsopoulos O and O Bugra O Ozer O are O funded O by O Cancer O Research O UK O core O funding O to O the O ICR’s B-ORG CRUK I-ORG Cancer I-ORG Therapeutic I-ORG Unit I-ORG C309/A25144 O Funding O for O open O access O charge O The O Charity O Open O Access O Fund O Albert O A. O Antolin O is O a O Henry B-ORG Wellcome I-ORG Research I-ORG Fellow O 204735/Z/16/Z O This O study O was O financially O supported O by O the O Excellent B-ORG Youth I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Scientific I-ORG Committee I-ORG SBK2015010297 O the O National B-ORG Key I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2014BAC08B04 O and O Key B-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BE2013704 O This O work O was O supported O by O a O Natural B-ORG Sciences I-ORG and I-ORG Engineering I-ORG Research I-ORG Council I-ORG of I-ORG Canada I-ORG Discovery I-ORG Grant I-ORG grant O number O 435596-2013 B-AWARD to O JMF O a O Human B-ORG Frontiers I-ORG Science I-ORG Program I-ORG Young I-ORG Investigator I-ORG Grant I-ORG grant O number O RGP0006/2015 B-AWARD to O JMF O SP O was O supported O by O an O Early B-ORG Career I-ORG Researcher I-ORG Award I-ORG of I-ORG Ontario I-ORG Canada I-ORG to O JMF O ER15-11-217 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Our O work O is O supported O by O grants O from O Consejo B-ORG Nacional I-ORG de I-ORG Investigaciones I-ORG Científicas I-ORG y I-ORG Técnicas I-ORG CONICET O PIP O 2021-2023 I-AWARD GI-11220200101549CO B-AWARD and O PUE B-AWARD 22920170100033 O Agencia B-ORG Nacional I-ORG de I-ORG Promoción I-ORG Científica I-ORG y I-ORG Tecnológica I-ORG ANPCyT O PICT2019-01664 O and O Universidad B-ORG de I-ORG Buenos I-ORG Aires I-ORG UBACYT O 2018-2020 I-AWARD 20020170100082BA O This O work O was O funded O by O Zhejiang B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Public I-ORG Welfare I-ORG Project I-ORG grant O no. O LGF18H160019 B-AWARD LGF20H160016 B-AWARD the B-ORG Scientific I-ORG Technology I-ORG Projects I-ORG of I-ORG Health I-ORG and I-ORG Medicine I-ORG of I-ORG Zhejiang I-ORG Province I-ORG grant O no. O WKJ-ZJ-1830 B-AWARD 2019KY207 B-AWARD and O Huzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Fund I-ORG grant O no. O 2017GY33 B-AWARD Financial O support O was O provided O by O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo–FAPESP I-ORG proc O 2011/03358-8 I-AWARD and O 2013/05120-4–scholarships B-AWARD granted O to O LP O Poli O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico–CNPq I-ORG proc O 475212/2011-8–research O grant O and O proc B-AWARD 307515/2015-0–research O scholarship O to O AI O Coan O and O proc B-AWARD 307907/2015-5–research O scholarship O to O LG O Temponi O and O Pró-Reitoria B-ORG de I-ORG Pesquisa I-ORG da I-ORG UNESP–PROPe I-ORG proc O 0330/019/13 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2020YFA0908200 O 2021YFA1101300 B-AWARD to O H.L O This O study O was O also O supported O partially O by O the O Major O Project O of O “Brain O Science I-ORG and I-ORG Brain-inspired I-ORG Research” O 2022ZD0211803 O to O L.Z O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82030032 O 32070960 B-AWARD 82261138555 B-AWARD to O L.Z O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG 2022CFA004 O to O L.Z O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2023A1515010483 O to O L.C O The O South-Eastern B-ORG Norway I-ORG Regional I-ORG Health I-ORG Authority I-ORG Project O numbers O 2016092 B-AWARD 2017058 B-AWARD 2020069 B-AWARD the O Norwegian B-ORG Cancer I-ORG Society I-ORG Project O number O 190397 B-AWARD the O Norwegian B-ORG Radium I-ORG Hospital I-ORG Research I-ORG Foundation I-ORG Project O number O SE1701 B-AWARD and O Internal B-ORG Funds I-ORG of I-ORG Akershus I-ORG University I-ORG Hospital I-ORG 2019 I-ORG project O number O 080 B-AWARD This O work O was O supported O by O the O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo I-ORG FAPESP O 2008/01724-4 B-AWARD 2018/25747-5 B-AWARD 2020/02207-5 B-AWARD 2021/14650-3 B-AWARD the O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG CAPES O Financial O Code O 001 B-AWARD and O the O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq O 312020/2019-8 B-AWARD This O work O was O supported O by O the O Young B-ORG Talent I-ORG Fund I-ORG of I-ORG University I-ORG Association I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG in I-ORG Shaanxi I-ORG China I-ORG 20170202 O Postdoctoral B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG 2017BSHEDZZ107 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2452018126 O and O Ph.D B-ORG research I-ORG start-up I-ORG foundation I-ORG of I-ORG Northwest I-ORG A&F I-ORG University I-ORG 2452016203 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O MOE B-ORG AcRF I-ORG Tier O 1 O Grant O No. O RG93/15 B-AWARD the O Joint B-ORG WASP/NTU I-ORG Programme I-ORG Project O No. O M4082189 B-AWARD and O the O DSAIR@NTU B-ORG Grant O Project O No. O M4082418 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O No. O 51968014 B-AWARD the O Guangxi B-ORG Natural I-ORG Science I-ORG Foundation I-ORG China I-ORG grant O No. O 2022GXNSFAA035553 B-AWARD 2020 B-AWARD GXNSFBA I-AWARD 297034 O and O Key B-ORG R&D I-ORG projects I-ORG in I-ORG the I-ORG Guangxi I-ORG Autonomous I-ORG Region I-ORG grant O No. O AA20302006 B-AWARD Guangxi B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Special I-ORG Project I-ORG grant O No. O Guike B-AWARD AA22068073 O and O Guangxi B-ORG Key I-ORG Laboratory I-ORG of I-ORG New I-ORG Energy I-ORG and I-ORG Building I-ORG Energy I-ORG Saving I-ORG Foundation I-ORG Nos O 22-J-21-7,20 B-AWARD This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2021YEB2900703 O the O BUPT B-ORG Excellent I-ORG PhD I-ORG Students’ I-ORG Foundation I-ORG CX2022308 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 62075014 O This O project O was O financially O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31625004 O and I-AWARD 31872653 O the O 111 B-ORG Project I-ORG B14027 O and O the O PLUS3 B-AWARD grant O from O the O Boehringer B-ORG Ingelheim I-ORG Foundation O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscrip O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31600296 B-AWARD Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Henan I-ORG Province I-ORG China I-ORG No. O 162102110097 B-AWARD and O Educational B-ORG Commission I-ORG of I-ORG Henan I-ORG Province I-ORG No. O 16A210033 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O Scientific B-ORG and I-ORG Technological I-ORG Research I-ORG Project I-ORG of I-ORG Jilin I-ORG Province I-ORG No. O 201201077 B-AWARD the O ‘Twelfth O Five-Year’ O Scientific B-ORG and I-ORG Technological I-ORG Research I-ORG Project I-ORG of I-ORG Education I-ORG Department I-ORG of I-ORG Jilin I-ORG Province I-ORG 2013 O No. I-AWARD 349 O Natural B-ORG Science I-ORG Foundation I-ORG Project I-ORG of I-ORG Shandong I-ORG Province I-ORG No. O ZR2011HL005 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O no. O 51975219 B-AWARD Basic B-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG of I-ORG GuangDong I-ORG Province I-ORG grant O number O no. O 2022A1515220053 B-AWARD and O the O Guangdong B-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG recognized I-ORG scientific I-ORG research I-ORG projects I-ORG of I-ORG ordinary I-ORG universities I-ORG grant O number O no. O 2020KQNCX103 B-AWARD This O study O was O financially O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Xinjiang I-ORG Uygur I-ORG Autonomous I-ORG Region I-ORG in I-ORG China I-ORG 2020D01C004 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81801008 O the O Scientific O Research O Project O of O Traditional O Chinese O Medicine O Bureau O of O Guangdong O Province O 20221267 O and O the O Science B-ORG Research I-ORG Cultivation I-ORG Program I-ORG of I-ORG Stomatological I-ORG Hospital I-ORG Southern I-ORG Medical I-ORG University I-ORG PY2021019 O and O PY2021003 B-AWARD This O research O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC0310900 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41476108 O the O Scientific B-ORG and I-ORG Technological I-ORG Innovation I-ORG Project I-ORG of I-ORG Qingdao I-ORG National I-ORG Laboratory I-ORG for I-ORG Marine I-ORG Science I-ORG and I-ORG Technology I-ORG 2016ASKJ08 O and I-AWARD 2015ASKJ02 O and O the O NSFC-Shandong O Joint O Fund O for O Marine O Science O Research O Centers O U1606403 O This O material O is O based O on O work O supported O by O Diabetes B-ORG UK I-ORG Grant O 15/0005284 B-AWARD H. O Chichger O American B-ORG Heart I-ORG Association I-ORG Grant O 13POST16860031 B-AWARD H. O Chichger O and O Wellcome B-ORG Trust I-ORG Vacation O Studentship O 202624/Z/16/Z B-AWARD P. O Lizunkova O and O H. O Chichger O The O sponsor O had O no O role O in O the O design O or O conduct O of O this O research O This O research O was O financially O supported O by O various O organizations O including O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 32172259 B-AWARD and O U1904110 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Henan I-ORG Province I-ORG grant O number O 212300410033 B-AWARD the O Program B-ORG for I-ORG the I-ORG Top I-ORG Young I-ORG Talents I-ORG of I-ORG Henan I-ORG Associate I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG 2021 I-ORG and I-ORG the I-ORG Innovative I-ORG Funds I-ORG Plan I-ORG of I-ORG Henan I-ORG University I-ORG of I-ORG Technology I-ORG 2021ZKCJ03 O This O research O was O funded O by O the O Fundamental B-ORG Research I-ORG Projects I-ORG of I-ORG Science I-ORG I-ORG Technology I-ORG Innovation I-ORG and I-ORG Development I-ORG Plan I-ORG in I-ORG Yantai I-ORG City I-ORG grant O number O 2022JCYJ035 B-AWARD the O Modern B-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG in I-ORG Shandong I-ORG Province I-ORG grant O number O SDAIT-26-05 B-AWARD and O the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG grant O number O 2017YFC1600702 B-AWARD This O study O was O funded O by O a O grant O from O the O American B-ORG Heart I-ORG Association I-ORG 13SDG17080033 O with O support O from O the O National B-ORG Institute I-ORG on I-ORG Aging I-ORG P30AG028740 O the O National B-ORG Center I-ORG for I-ORG Medical I-ORG Rehabilitation I-ORG Research I-ORG P2CHD086851 O T32HD071866 O and O the O University O of O Alabama O at O Birmingham O Center O for O Exercise O Medicine O Professional O effort O for O L.C.B O and O T.W.B O was O also O supported O by O R01AG056769 B-AWARD from O the O National O Institute O on O Aging O This O work O received O funding O from O theBritish O Heart I-ORG Foundation[PG/13/46/30329 O RG/17/12/33167 B-AWARD theEuropean O Union's I-ORG Seventh I-ORG Framework I-ORG Programme[FP7/2007-2013,project O EarlyNutrition O grant O agreement O n°289346],MRC O Metabolic I-ORG Diseases I-ORG Unitaward O MC_UU_12012/4 O andBritish O Heart I-ORG Foundation I-ORG Studentship[(to O JB) O FS/14/59/31282 B-AWARD LD O is O a O Sir O Henry O Wellcome O Post-Doctoral O Fellow O 106026/Z/14/Z O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31270344 O MICINN B-ORG Spain I-ORG BIO2014-54441-P O International B-ORG Science I-ORG I-ORG Technology I-ORG Cooperation I-ORG Project I-ORG supported I-ORG by I-ORG Jilin I-ORG Provincial I-ORG Science I-ORG I-ORG Technology I-ORG Department I-ORG China I-ORG 20190201013JC O PROGRAMA B-ORG ESTATAL I-ORG DE I-ORG INVESTIGACIÓN I-ORG CIENTÍFICA I-ORG Y I-ORG TÉCNICA I-ORG DE I-ORG EXCELENCIA I-ORG Spain I-ORG BIO2015-71703-REDT O BIO2017-90877-REDT O European B-ORG Cooperation I-ORG in I-ORG Science I-ORG and I-ORG Technology I-ORG EUROCAROTEN O OC-2015-1-19780 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O China B-ORG Modern I-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG CARS-36 O Research B-ORG Program I-ORG of I-ORG Hebei I-ORG Province I-ORG 16226604D O Hebei B-ORG Dairy I-ORG Cattle I-ORG Innovation I-ORG Team I-ORG of I-ORG Modern I-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG HBCT2018120203 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31872330 O and O the O Program B-ORG for I-ORG Changjiang I-ORG Scholar I-ORG and I-ORG Innovation I-ORG Research I-ORG Team I-ORG in I-ORG University I-ORG IRT_15R62 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O or O in O the O decision O to O publish O or O in O preparing O the O paper O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31272442 O and O National B-ORG Transgenic I-ORG New I-ORG Species I-ORG Breeding I-ORG Program I-ORG of I-ORG China I-ORG 2014ZX08006-01B O and O National B-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Higher I-ORG Education I-ORG Institutions I-ORG of I-ORG Anhui I-ORG Province I-ORG KJ2016A227 O This O work O was O supported O by O grants O from O the O Key B-ORG Innovation I-ORG Plan I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG KSCX2-EW-N-004 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 30970341 O and I-AWARD 31572258 O and O the O Open B-ORG Foundation I-ORG from I-ORG the I-ORG Qinghai I-ORG Key I-ORG Laboratory I-ORG of I-ORG Tibetan I-ORG Medicine I-ORG Pharmacology I-ORG and I-ORG Safety I-ORG Evaluation I-ORG 2014-ZY-03 O This O research O was O funded O by O National B-ORG Institutes I-ORG of I-ORG Health O grant O number O R01AI159454 B-AWARD R01CA227699 B-AWARD R01AI139401 B-AWARD R01EB029805 B-AWARD and O RadXRad B-ORG Program I-ORG grant O U01AA029348 B-AWARD National B-ORG Science I-ORG Foundation O grant O number O NSF B-AWARD RAPID I-AWARD 20-27778 O CBET B-AWARD 20-29215 I-AWARD Major B-ORG Research I-ORG Projects I-ORG in I-ORG Philosophy I-ORG and I-ORG Social I-ORG Sciences I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG grant O no.17JZD013 O recipient O Jie O Huang O Support B-ORG Plan I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG Talents I-ORG in I-ORG Henan I-ORG Institutions I-ORG of I-ORG Higher I-ORG Learning I-ORG humanities O and O social O sciences O grant O no. O 2021-CX-54 B-AWARD recipient O Jie O Huang O and O Youth B-ORG Project I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 72203197 B-AWARD recipient O Jie O Huang O Nanhu O Scholars O Program O for O Young O Scholars O of O Xinyang O Normal O University O grant O no. O 2023019 O recipient O Jie O Huang O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O Key B-ORG Project I-ORG of I-ORG NSFC-Henan I-ORG Province I-ORG Joint I-ORG Fund I-ORG U1704233 O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-40-K04 O and O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017M520301 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 32172933 B-AWARD and O 31872528 B-AWARD the O Key B-ORG R&D I-ORG Program I-ORG of I-ORG Ningxia I-ORG Hui I-ORG Autonomous I-ORG Region I-ORG of I-ORG China O grant O number O 21BEF02019 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Ningxia I-ORG Hui I-ORG Autonomous I-ORG Region O grant O number O 2022AAC02072 B-AWARD This O research O was O funded O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O no. O 2021YFD2200700 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG China I-ORG grant O no. O 2572022DQ01 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O nos O 32001332 B-AWARD and O 32001331 B-AWARD This O work O was O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG province I-ORG 2015A030310078 O Guangdong B-ORG Medical I-ORG Research I-ORG Foundation(A2018103 O and O Shantou B-ORG Science I-ORG and I-ORG Technology I-ORG Fund I-ORG 2017026 O This O research O is O funded O by O Shanghai B-ORG Municipal I-ORG Education I-ORG Commission O grant O number O ZZSDJU19012 B-AWARD Shanghai B-ORG CCP I-ORG Committee I-ORG of I-ORG Education I-ORG and I-ORG Health I-ORG Work O grant O number O TZYJ-2019-B37 B-AWARD and O Shanghai B-ORG Dianji I-ORG University O grant O number O 19AR20 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81773944];Natural O Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20180927];the O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG for I-ORG Youths I-ORG BK20170516];Wuxi O City I-ORG Health I-ORG Planning I-ORG Commission I-ORG project I-ORG MS201815];Young O Medicine I-ORG Focus I-ORG Talent I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG QNRC2016206];Postgraduate O Research I-ORG by I-ORG Practice I-ORG Innovation I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG KYCX18_2382 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81660421 O 81860450 O the O High-level B-ORG Personnel I-ORG Funded I-ORG Projects I-ORG grant O number O 2011 B-AWARD The O Science B-ORG and I-ORG Technology I-ORG benefits I-ORG of I-ORG Zunyi I-ORG and I-ORG the I-ORG First I-ORG People’s I-ORG Hospital I-ORG of I-ORG Zunyi I-ORG Joint I-ORG Research I-ORG and I-ORG Development I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG grant O number O 2011)24 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG benefits I-ORG of I-ORG Guizhou I-ORG grant O number O 2010)66 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O study O and O article O processing O were O supported O by O grants O given O to O author O Guang O Wang O from O the O Capital B-ORG Clinical I-ORG Research I-ORG Foundation I-ORG of I-ORG Beijing I-ORG Municipal I-ORG Commission I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG No. O Z161100000516069 B-AWARD grants O from O the O Chinese B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 81600657 B-AWARD Beijing B-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospitals’ I-ORG Youth I-ORG Programme I-ORG QML20150308 O given O to O author O Jia O Liu O and O by O funding O provided O by O the O Bayer O Healthcare O China O and O Double O Crane O Pharma O This O study O was O partially O funded O by O the O Research B-ORG and I-ORG Education I-ORG Fund I-ORG of I-ORG the I-ORG Hospital I-ORG de I-ORG Clínicas I-ORG de I-ORG Porto I-ORG Alegre I-ORG FIPE/HCPA O grant O number O n°130484 B-AWARD 1.893.438 B-AWARD 3.313.746 B-AWARD 2015-0279 B-AWARD 18-0178 B-AWARD and O 2018-0642 B-AWARD L.d.O.C O and O L.B.D O received O a O scholarship O from O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG CAPES)-finance O code O 001 B-AWARD S.C.F O has O a O fellowship O of O CNPq B-ORG no O 309023/2015-7 B-AWARD This O study O was O supported O by O grants O from O the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0501409-02 O the B-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG CAAS-XTCX2016011-01 O and O the B-ORG National I-ORG Chicken I-ORG Industry I-ORG Technology I-ORG System I-ORG of I-ORG China I-ORG CARS-41 O This O work O was O supported O by O the O National O Institute O of O Health O NIH O National B-ORG Institute I-ORG on I-ORG Deafness I-ORG and I-ORG Other I-ORG Communication I-ORG Disorders I-ORG Grant O No. O R01DC003083 B-AWARD R.Y.L O the O Acoustical B-ORG Society I-ORG of I-ORG America I-ORG Frederick B-AWARD V. I-AWARD Hunt I-AWARD Postdoctoral I-AWARD Research I-AWARD Fellowship I-AWARD in I-AWARD Acoustics I-AWARD M.W O and O in O part O by O NIH O Eunice B-ORG Kennedy I-ORG Shriver I-ORG National B-ORG Institute I-ORG of I-ORG Child I-ORG Health I-ORG and I-ORG Human I-ORG Development I-ORG Grant O No. O T32HD007489 B-AWARD Z.E.P O and O U54HD090256 B-AWARD to O the O University O of O Wisconsin-Madison O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O foundation O of O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG and O Science O Grant/Award O Number O 81874105 B-AWARD National B-ORG Clinical I-ORG Research I-ORG Center I-ORG for I-ORG Gynecological I-ORG Oncology O Grant/Award O Number O 2015BAI13B05 B-AWARD National O Natural O Science O Foundation O of O China O and O Science O Grant/Award O Number O 81372809 B-AWARD and O National B-ORG Key I-ORG Research I-ORG I-ORG Development I-ORG Program I-ORG of I-ORG China O Grant/Award O Number O 2016YFC1302903 B-AWARD The O funding O sources O acknowledged O the O design O of O the O study O but O did O not O influence O the O process O of O our O study O including O data O collection O analysis O and O interpretation O and O the O reporting O of O results O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81970980 B-AWARD the O Zhejiang B-ORG Health I-ORG Department I-ORG Co-construction I-ORG Key I-ORG Projects I-ORG of I-ORG Provinces I-ORG and I-ORG Ministries I-ORG WKJ-ZJ-2023 O Liaoning B-ORG Province I-ORG Colleges I-ORG and I-ORG Universities I-ORG Basic I-ORG Research I-ORG Project I-ORG No. O LFWK201717 B-AWARD The O Liaoning B-ORG Provincial I-ORG Key I-ORG Research I-ORG Plan I-ORG Guidance I-ORG Project I-ORG No. O 2018225078 B-AWARD The O Liaoning B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Guidance I-ORG Project I-ORG No. O 2019-ZD-0749 B-AWARD the O Central B-ORG Government I-ORG of I-ORG Liaoning I-ORG Province I-ORG to I-ORG Guide I-ORG Local I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Project I-ORG No. O 2017108001 B-AWARD the O Shenyang B-ORG Major I-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG No. O 19-112-4-027 B-AWARD Shenyang B-ORG Young I-ORG and I-ORG Middle-aged I-ORG Technological I-ORG Innovation I-ORG Talent I-ORG Plan I-ORG No. O RC200060 B-AWARD the O Second B-ORG Batch I-ORG of I-ORG Medical I-ORG Education I-ORG Scientific I-ORG Research I-ORG Projects I-ORG of I-ORG the I-ORG 13th I-ORG Five-Year I-ORG Plan I-ORG of I-ORG China I-ORG Medical I-ORG University I-ORG No. O YDJK2018017 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2018YFD0100306 O and O 2018YFD0100800 B-AWARD the O Key B-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Henan I-ORG Province I-ORG of I-ORG China I-ORG 192102110032 O and O the O Key B-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG Henan I-ORG Higher I-ORG Education I-ORG Institutions I-ORG 19A210016 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O project O was O granted O financial O support O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 22005060 B-AWARD Grant O No. O 21962003 B-AWARD and O Grant O No. O 22265001 B-AWARD Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Jiangxi I-ORG Province I-ORG Grant O No. O 20202BBEL53032 B-AWARD and O Major B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Jiangxi I-ORG Province I-ORG “The I-ORG Open I-ORG Competition I-ORG Mechanism I-ORG to I-ORG Select I-ORG the I-ORG Best I-ORG Candidates” I-ORG Grant O No. O 20212AAF01006 B-AWARD This O work O was O supported O by O Zhejiang B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG grants O no. O LGF22H160017 B-AWARD to O M.C O and O LGF22H160046 B-AWARD to O H.L O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 82104445 B-AWARD to O H.L O and O Jinhua B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG grants O no. O 2021-3-040 B-AWARD to O K.J O and O 2021-3-046 B-AWARD to O H.L O The O study O design O was O supported O by O the O National B-ORG key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC1310300 O 2016YFC1306600 B-AWARD the O data O collection O was O supported O by O Projects B-ORG of I-ORG National I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81400925,81471148,81703825 O the O data O input O and O analysis O were O supported O by O Projects B-ORG of I-ORG the I-ORG Shanghai I-ORG Committee I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 17401901000 O and O SHSMU-ION B-ORG Research I-ORG Center I-ORG for I-ORG Brain I-ORG Disorders I-ORG 2015NKX007 O The O funding O body O was O not O involved O in O the O data O interpretation O and O writing O This O research O was O funded O by O FWO O and O F.R.S.-FNRS O under O the O Excellence O of O Science O Program O EOS O MODEL-IDI B-ORG Ref O number O 30826052 B-AWARD and O CD-INFLADIS B-ORG Ref O number O 40007512 B-AWARD A.C.P O is O funded O by O FCT B-ORG SFRH/BD/14611/2019 B-AWARD I.S.L O was O funded O by O FCT O SFRH/BD/114552/2016 B-AWARD and O is O funded O by O MODEL-IDI O Ref O number O 30826052 O A.C.M O was O funded O by O FCT O SFRH/BD/104599/2014 B-AWARD R.G O was O funded O by O FCT O IF B-AWARD 01495/2015 I-AWARD The O National B-ORG Natural I-ORG Science I-ORG Foundations I-ORG of I-ORG China I-ORG Nos O 61674124 O 11604275 O 11304257 B-AWARD and O 61227009 B-AWARD the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFB0400801 B-AWARD the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG of I-ORG China I-ORG No. O 2014J01026 O 2016J01037 B-AWARD and O 2015J01028 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Nos O 20720160122 O 20720150033 B-AWARD and O 20720160044 B-AWARD provided O support O in O writing O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81672922 O Medical B-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Provincial I-ORG Health I-ORG Commission I-ORG No. O 2017174160 O Wenzhou B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG No. O Y20160044 O Innovation B-ORG Discipline I-ORG of I-ORG Zhejiang I-ORG Province I-ORG in I-ORG Nucleic I-ORG Acid I-ORG Molecular I-ORG Diagnostics I-ORG No. O 437201702G O and O Key B-ORG Discipline I-ORG of I-ORG Zhejiang I-ORG Province I-ORG in I-ORG Medical I-ORG Technology I-ORG First O Class O Category O A) O No.437601607 O This O work O is O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 11704055 B-AWARD 31670516 B-AWARD 31470552 B-AWARD the O Liaoning B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O No. O 20180510021 B-AWARD the O Dalian B-ORG High-level I-ORG Talents I-ORG Innovation I-ORG Supporting I-ORG Program I-ORG Grant O No. O 2017RQ073 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No. O 3132019212 B-AWARD and O 3132019348 B-AWARD The O authors O are O thankful O for O the O financial O support O provided O by O the O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG do I-ORG Rio I-ORG de I-ORG Janeiro I-ORG FAPERJ I-ORG Brazil—grantnumber O E26/202.227/2018 O and O E26/204.078/2022 O the O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq)—grantnumber O 313119/2020-1 O and O the O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG CAPES I-ORG Brazil—FinanceCode001 O The O authors O acknowledge O the O financial O assistance O provided O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31600770 B-AWARD the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2014CB541603 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O Nos O 10611CDJXZ238826 B-AWARD and O 106112017CDJXY230006 B-AWARD This O research O was O supported O by O the O Basic O Science O Research O Program O of O the O National O Research O Foundation O of O Korea O NRF O and O Rural O Development O Administration O funded O by O the O Ministry B-ORG of I-ORG Education I-ORG No. O 2014R1A6A3A04059193 B-AWARD Science B-ORG and I-ORG Technology I-ORG No. O 2014R1A1A2059813 B-AWARD and O Cooperative O Research O Program O for O Agriculture B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG No. O PJ0137522019 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O authors O acknowledge O the O financial O support O from O the O advanced O research O fund O of O Shaanxi B-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG SUST O 2017BJ-34 O the O Natural B-ORG Science I-ORG Basic I-ORG Research I-ORG Plan I-ORG in I-ORG Shaanxi I-ORG Province I-ORG of I-ORG China I-ORG 2023-JC-YB-114 O and O 2018JQ2016 B-AWARD and O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Pulp I-ORG and I-ORG Paper I-ORG Engineering I-ORG South O China O University O of O Technology O No. O 201604 B-AWARD This O work O was O supported O by O the O project O of O Chengdu B-ORG Giant I-ORG Panda I-ORG Breeding I-ORG Research I-ORG Foundation I-ORG CPF2014-03 O Chengdu B-ORG Research I-ORG Base I-ORG of I-ORG Giant I-ORG Panda I-ORG Breeding I-ORG 2021CPB-B07 O Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG 2020YFH0145 O 2021YFH0157 B-AWARD and O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2022YFD1301300 O This O work O was O supported O by O the O Major B-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG of I-ORG Guangdong I-ORG Province I-ORG no. O 2015B020225005 B-AWARD the O Basic B-ORG Research I-ORG Fund I-ORG of I-ORG Shenzhen I-ORG City I-ORG JCYJ20150402111430633 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31300813 O This O work O was O supported O by O the O Regionale B-ORG Foskningsfond I-ORG Vestalandet I-ORG project O Utvikling O av O en O sesonguavhengig O protokoll O for O intensiv O produksjon O av O regnbueørret O O. O mykiss O Development O of O a O season O independent O protocol O for O the O intensive O production O of O rainbow O trout O O. O mykiss O RFFVest O project I-AWARD 248020 O the O CtrlAQUA B-ORG SFI O Centre O for O Closed-Containment O Aquaculture O programme O SFI O project I-AWARD 237856 O and O by O Japan O Society O for O the O Promotion O of O Science O Bilateral O Joint O Research O Project O Open O Partnership O with O Norway O This O work O also O received O funding O from O the O MASTS B-ORG pooling O initiative O The O Marine O Alliance O for O Science O and O Technology O for O Scotland O grant O SASG9 B-AWARD and O their O support O is O gratefully O acknowledged O MASTS O is O funded O by O the O Scottish O Funding O Council O grant O reference O HR09011 O and O contributing O institutions O This O work O was O funded O by O the B-ORG University I-ORG Nursing I-ORG Program I-ORG for I-ORG Young I-ORG Scholar I-ORG with I-ORG Creative I-ORG Talents I-ORG in I-ORG Heilongjiang I-ORG Province I-ORG UNPYSCT-2016012 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31101868 O Financial B-ORG Assistance I-ORG from I-ORG Postdoctoral I-ORG Scientific I-ORG Research I-ORG Developmental I-ORG Fund I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG LBH-Q16013 O Scientific B-ORG Research I-ORG Foundation I-ORG for I-ORG the I-ORG Returned I-ORG Overseas I-ORG Chinese I-ORG Scholars I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG LC2017007 O The O authors O are O grateful O for O financial O support O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 51522503 B-AWARD and O support O from O Program B-ORG for I-ORG New I-ORG Century I-ORG Excellent I-ORG Talents I-ORG in I-ORG University I-ORG NCET-13-0175 O This O work O was O also O supported O partially O by O the O High-level B-ORG university I-ORG construction I-ORG fund I-ORG for I-ORG SUSTech I-ORG G01256018 O We O are O grateful O to O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21776112 O O 21506073 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20171135 O the O national B-ORG first-class I-ORG discipline I-ORG program I-ORG of I-ORG Light I-ORG Industry I-ORG Technology I-ORG and I-ORG Engineering I-ORG LITE2018-07 O the O Program O of O Introducing O Talents O of O Discipline O to O Universities O 111-2-06 O and O Top-notch O Academic O Programs O Project O of O Jiangsu O Higher O Education O Institutions O for O the O financial O support O of O this O research O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32070301 O 31872659 O the O National B-ORG Genetically I-ORG Modified I-ORG Organisms I-ORG Breeding I-ORG Major I-ORG Projects I-ORG 2016ZX08009002 O and O Exploration B-ORG project I-ORG of I-ORG Center I-ORG for I-ORG Practical I-ORG Courses I-ORG in I-ORG the I-ORG Life I-ORG Sciences I-ORG of I-ORG China I-ORG Agricultural I-ORG University I-ORG 20210102 O 20210103 O We O acknowledge O the O Medical B-ORG Research I-ORG Council I-ORG for O Award O Number O MR/K010174/1 B-AWARD Principal O Investigator O NMF O the O Bill B-ORG and I-ORG Melinda I-ORG Gates I-ORG Foundation I-ORG for O Award O Number O OPP1092240 B-AWARD NMF O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG for O Award O Number O 1U01GM110721-01 B-AWARD Principal O Investigator O NMF O the O EU B-ORG for O Award O Number O 278433-PREDEMICS B-AWARD to O CAD O and O the O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG for O Award O Number O HPRU-2012-10080 B-AWARD Principal O Investigator O NMF O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O funds O from O The B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0100103 O the O Nanning B-ORG Comprehensive I-ORG Test I-ORG Station I-ORG of I-ORG National I-ORG Rice I-ORG Industry I-ORG Technology I-ORG System I-ORG CARS-01-88 O the O Special O Fund O for O Guangxi O Science O and O Technology O Base O and O Talents O AD17129064 O the O Guangxi B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2018GXNSFAA281202 O the O Guangxi O Science O and O Technology O Base O and O Special O Talents O GuiKe O AD18050003 O and O the O Open O Subject O of O Key O Laboratory O of O Rice O Genetics O and O Breeding O in O Guangxi O 160-380-16-9 O The O authors O acknowledge O support O by O the O Medical B-ORG Research I-ORG Council I-ORG UK O G0501494 O G1100090 B-AWARD and O MR/L023091/1 B-AWARD the O Wellcome B-ORG Trust I-ORG 076343 O Asthma B-ORG UK I-ORG AUK-IG-2016-338 O Breast B-ORG Cancer I-ORG Now I-ORG 147 O working O in O partnership O with O Walk O the O Walk O Cancer B-ORG Research I-ORG UK I-ORG C30122/A11527 O and O C30122/A15774 B-AWARD and O CRUK/NIHR O in O England/DoH O for O Scotland O Wales O and O Northern O Ireland O Experimental O Cancer O Medicine O Centre O C10355/A15587 O The O research O was O supported O by O the O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG NIHR O Biomedical O Research O Centre O BRC O based O at O Guy’s O and O St O Thomas’ O NHS O Foundation O Trust O and O King’s O College O London O IS-BRC-1215-20006 O The O authors O are O solely O responsible O for O study O design O data O collection O analysis O decision O to O publish O and O preparation O of O the O manuscript O The O views O expressed O are O those O of O the O authors O and O not O necessarily O those O of O the O NHS O the O NIHR O or O the O Department O of O Health O This O work O was O supported O in O whole O or O in O part O by O the O Al B-ORG Jalila I-ORG Foundation O internal O grant O awards O from O Mohammed B-ORG Bin I-ORG Rashid I-ORG University I-ORG of I-ORG Medicine I-ORG and I-ORG Health I-ORG Sciences I-ORG MBRU)—College O of O Medicine O MBRU-CM-RG2018-04 O MBRU-CM-RG2018-05 B-AWARD MBRU-CM-RG2020-02 B-AWARD and O MBRU-CM-RG2020-12 B-AWARD Sandooq B-ORG Al I-ORG Watan I-ORG Research I-ORG I-ORG Development I-ORG Grant I-ORG SWARD-F2018-002 O AlMahmeed B-ORG Collaborative I-ORG Research I-ORG Awards I-ORG ALM1801 O ALM20-0074 B-AWARD and O Al O Jalila O Foundation O Grant O AJF201763 O Dr. O Nasna O Nassir O was O supported O by O MBRU O Post-Doctoral O Fellow O Award O MBRU-PD-2020-02 O Dr. O Richa O Tambi O was O supported O by O MBRU O Post-Doctoral O Fellow O Award O MBRU-PD-2020-04 O The O study O was O funded O by O the O Qatar B-ORG National I-ORG Research I-ORG Fund I-ORG – O National O Priorities O Research O Program O NPRP O O 5-1327-2-568 B-AWARD the O Charité O – O Universitätsmedizin O Berlin O owned O funding O the O Swedish B-ORG Heart I-ORG and I-ORG Lung I-ORG Foundation I-ORG grant O 20120811 B-AWARD 20160584 O the O Russian O Federation O RF O Government O # O 075-15-2019-1885 O and O the O agreement O concerning O research O and O education O of O doctors O at O the O Sahlgrenska B-ORG University I-ORG Hospital I-ORG LUA O ALF I-AWARD ALFGBG-534591 I-AWARD and I-AWARD 725601 O The O funder O ASR O Advanced O Sleep O Research O GmbH O provided O support O in O the O form O of O salary O for O author O KL. O The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O specific O roles O of O these O authors O are O articulated O in O the O ‘author O contributions’ O section O This O research O was O funded O by O the B-ORG Jiangsu I-ORG Graduate I-ORG Research I-ORG and I-ORG Practice I-ORG Innovation I-ORG Project I-ORG Grant O NO. O SJCX21_0344 B-AWARD Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Housing I-ORG and I-ORG Urban-Rural I-ORG Development I-ORG PRC I-ORG Grant O NO. O 2018-K9-074;2019-K-140 B-AWARD and O Nanjing B-ORG Forestry I-ORG University I-ORG Youth I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Fund I-ORG Grant O NO. O CX2019031 B-AWARD This O work O was O supported O by O the O KU B-ORG Leuven I-ORG C3 O project O C32/17/007 B-AWARD C3 O project O C3/21/014 B-AWARD ID-N O project O IDN/20/011 B-AWARD and O Research B-ORG Foundation–Flanders I-ORG FWO-SBO O project O S003923N B-AWARD The O KU O Leuven O XCT O Core O facility O received O funding O from O the O Hercules B-ORG Foundation I-ORG Flanders I-ORG I013518N O This O research O was O funded O by O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG Grant O No O 1126955 B-AWARD Cancer B-ORG Institute I-ORG of I-ORG New I-ORG South I-ORG Wales O TPG B-AWARD 182165 I-AWARD and O SW-TCRC B-ORG Partner I-ORG Program I-ORG grant O 2019 B-AWARD This O research O was O supported O by O the O California B-ORG Breast I-ORG Cancer I-ORG Research I-ORG Program I-ORG grant O number O 20IB-0114 B-AWARD and O 16ZB-8501 B-AWARD The O parent O study O the O California O Teachers O Study O was O supported O by O the O National B-ORG Cancer I-ORG Institute I-ORG of O the O National O Institutes O of O Health O under O award O numbers O U01-CA199277 B-AWARD P30-CA033572 B-AWARD P30-CA023100 B-AWARD UM1-CA164917 B-AWARD and O R01-CA077398 B-AWARD E.L O was O supported O by O a O Career O Catalyst O Grant O CCR15333900 B-AWARD from O Susan B-ORG G. I-ORG Komen I-ORG Foundation O while O part O of O this O research O was O conducted O The O APC O was O funded O by O Susan O G. O Komen O Foundation O This O work O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC1102605 O 2016YFC1102603 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81870786 O the O Medical B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG B2018119 O the O Science B-ORG Foundation I-ORG of I-ORG Southern I-ORG Medical I-ORG University I-ORG PY2018N093 O This O project O was O supported O by O the O German B-ORG Academic I-ORG Exchange I-ORG Service I-ORG DAAD O project O ID: O 57589445 B-AWARD the O German B-ORG Research I-ORG Foundation I-ORG DFG O DE O no. O 1593/5-1 B-AWARD and O the O TÜBITAK B-ORG project O no. O 121N190 B-AWARD This O work O was O supported O by O grants O from O the O “Fondo O de I-ORG Investigaciones I-ORG Sanitarias” O FIS O PI17-01489 O the O Miguel O Servet O Program O CP11/00147 O del O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III I-ORG AAS O and O the O Ministerio B-ORG de I-ORG Economía I-ORG y I-ORG Competitividad–FEDERER I-ORG RTC-2016-4990-1 O IPA O was O supported O by O “Ayudas O para O la O contratación O de O ayudantes O de O investigación O cofinanciadas O por O el O Fondo O Social O Europeo O a O través O del O Programa O Operativo O de O Empleo O Juvenil O y O la O Iniciativa O de O Empleo O Juvenil O YEI),” O and O SER O was O supported O by O FPI-CEU O predoctoral O fellowship O This O research O was O funded O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2020YFA0210800 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 21974022 B-AWARD and O 22027805 B-AWARD Major B-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Fujian I-ORG Province I-ORG 2020HZ06006 O PD O is O supported O by O grants O from O the O Department B-ORG of I-ORG Defense I-ORG CA201135 O and O the O American B-ORG Gastroenterological I-ORG Association I-ORG Research I-ORG Scholar I-ORG Award I-ORG 2021RSA-12522 O The O Flow O Cytometry O Core O Laboratory O is O sponsored O in O part O by O the O NIH B-ORG COBRE I-ORG program I-ORG of I-ORG the I-ORG NCRR I-ORG P20 B-AWARD RR016443 I-AWARD and O The B-ORG University I-ORG of I-ORG Kansas I-ORG Cancer I-ORG Center I-ORG P30CA168524–01 B-AWARD grants O This O study O was O financially O supported O by O grants O from O Medical O excellent O youth O training O program O of O Shanghai B-ORG Municipal I-ORG Health I-ORG Bureau I-ORG #2017YQ073 O Multiple O discipline O research O program O of O Shanghai B-ORG Jiao I-ORG Tong I-ORG University(#YG2016MS34 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG #81400723 O The O funders O of O this O study O do O not O have O any O roles O in O study O design O data O collection O analysis O result O interpretation O writing O and O the O decision O to O submit O the O manuscript O for O publication O This O study O was O supported O by O research O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31602153 O Laboratory B-ORG for I-ORG Marine I-ORG Fisheries I-ORG Science I-ORG and I-ORG Food I-ORG Production I-ORG Processes I-ORG Qingdao I-ORG National I-ORG Laboratory I-ORG for I-ORG Marine I-ORG Science I-ORG and I-ORG Technology I-ORG China I-ORG P. I-ORG R. I-ORG China I-ORG 2016LMFS-B02 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2016CQ32 O and O the B-ORG Key I-ORG Laboratory I-ORG of I-ORG Mariculture I-ORG Ministry I-ORG of I-ORG Education I-ORG Ocean I-ORG University I-ORG of I-ORG China I-ORG KLM2018004 O The O funding O bodies O did O not O contribute O to O the O design O of O the O study O sample O collection O analysis O interpretation O of O data O or O in O writing O the O manuscript O This O research O was O supported O by O Shenzhen B-ORG Healthcare I-ORG Research I-ORG Project I-ORG No. O SZFZ2017024 B-AWARD the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIAID O 1R01AI114310 O and O the O UNC-South B-ORG China I-ORG STD I-ORG Research I-ORG Training I-ORG Center I-ORG FIC O 1D43TW009532 O The O funders O played O no O role O in O any O part O of O the O study O This O work O was O supported O by O a O National B-ORG Institute I-ORG of I-ORG Health I-ORG Research I-ORG NIHR O Collaboration O for O Leadership O in O Applied O Health O Research O and O Care O CLAHRC O implementation O grant O KRD/012/001/006 O an O NIHR B-ORG applied I-ORG programme I-ORG grant I-ORG RP-PG-0407-10044 O and O an O Economic B-ORG and I-ORG Social I-ORG Research I-ORG Council I-ORG ESRC O research O grant O RES-177-25-0016 O The O views O expressed O are O those O of O the O authors O and O not O necessarily O those O of O the O NHS O the O NIHR O or O the O Department O of O Health O The O funders O had O no O role O in O study O design O data O collection O and O analysis O Research O grant O AGL2013-43571-P B-AWARD Ministerio O de I-ORG Economía I-ORG y I-ORG Competitividad I-ORG MINECO I-ORG FEDER O HA. O Research O grant O UJA2014/07/02 B-AWARD Plan O Propio I-ORG UJA O HA. O Research B-ORG Team I-ORG EI_BIO1_2017 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the O U.S O Army O Medical B-ORG Research I-ORG and I-ORG Materiel I-ORG Command I-ORG through O grant O number O W81XWH-11-1-0781 B-AWARD Supplemental O support O was O provided O by O the O Analytical O Core O of O the O Center O for O Appalachian O Research O in O Environmental O Sciences O National B-ORG Institute I-ORG of I-ORG Environmental I-ORG Health I-ORG Sciences I-ORG grant O number O 1P30ES026529-01A1 B-AWARD This O research O was O supported O by O the O Biostatistics O and O Bioinformatics O Cancer O Research O Informatics O and O Biospecimen O and O Tissue O Procurement O Shared O Resources O of O the O University O of O Kentucky O Markey O Cancer O Center O which O is O funded O by O the O National B-ORG Cancer I-ORG Institute I-ORG through O P30CA177558 B-AWARD This O work O was O supported O by O The O National O Nature O Science O Foundation O of O China O 81502015 O and O Shanghai B-ORG Rising-Star I-ORG Program I-ORG 16QA1402700 O to O Ji-Lin O Wang O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG from O Hua O Xiong O 81570494 O the O National O Nature O Science O Foundation O of O China O 81572326 O and O National O Natural O Science O Foundation–Outstanding O Youth O Foundation O 81322036 O to O Jie O Xu, O the B-ORG Major I-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81530072 O the O Projects O of O International O Cooperation O and O Exchanges O NSFC O 81320108024 O and O the O Innovative O group O projects O 81421001 O to O Jing-Yuan O Fang O This O work O was O supported O by O grants O from O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG 2013BAD20B03 O Key B-ORG Project I-ORG from I-ORG the I-ORG Government I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 2013KTZB02-03-1 O a O Public B-ORG Welfare I-ORG Project I-ORG from I-ORG the I-ORG Ministry I-ORG of I-ORG Forestry I-ORG 201304110 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 2014YB074 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31372019 O Talents B-ORG Supporting I-ORG Plan I-ORG of I-ORG Shaanxi I-ORG Province I-ORG a I-ORG special I-ORG fund I-ORG from I-ORG the I-ORG Key I-ORG laboratory I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 2015SZS-10 O a O special B-ORG fund I-ORG from I-ORG NWAFU I-ORG for I-ORG the I-ORG jujube I-ORG experimental I-ORG station I-ORG XTG2015002 O and O the B-ORG United I-ORG States I-ORG National I-ORG Science I-ORG Foundation I-ORG IOS-1539831 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 51605139 B-AWARD and O 51505479 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grant O No. O BK20160867 B-AWARD the O Fundamental O Research O Funds O for O the O Central O Universities O Grant O No. O 2017B12814 O and O 2018B48414 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2016M591752 O and O the O Jiangsu B-ORG Planned I-ORG Projects I-ORG for I-ORG Postdoctoral I-ORG Research I-ORG Funds I-ORG Grant O No. O 1501041A B-AWARD This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG No. O 2016YFA0300801 B-AWARD the B-ORG Sichuan I-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Project I-ORG No. O 2016GZ0250 B-AWARD and O the B-ORG International I-ORG Cooperation I-ORG Project I-ORG 2013HH0003 B-AWARD and O 111 B-ORG Project I-ORG No. O B13042 B-AWARD Lindsay O Reed O is O supported O by O a O King’s O College O London O Health O Faculty O PhD O Studentship O funded O by O the O Medical B-ORG Research I-ORG Council I-ORG grant O 1524896 B-AWARD Work O at O King’s O College O London O is O supported O by O Cancer B-ORG Research I-ORG UK I-ORG Grant O C313/A14329 B-AWARD Wellcome B-ORG Trust I-ORG Grants O 101126/Z/13/Z B-AWARD and O 101126/B/13/Z B-AWARD Natural B-ORG Environment I-ORG Research I-ORG Council I-ORG Grant O NE/L006782/1 B-AWARD and O in O part O by O the O National O Institute O for O Health O Research O Health O Protection O Research O Unit O NIHR O HPRU O in O Health O Impact O of O Environmental O Hazards O at O King’s O College O London O in O partnership O with O Public O Health O England O PHE O The O views O expressed O are O those O of O the O authors O and O not O necessarily O those O of O the O NHS O the O NIHR O the O Department O of O Health O or O PHE O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31771582 O and O 31271445 B-AWARD the O Guangdong B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 2017A030313131 O the O “Thousand B-ORG Hundred I-ORG and I-ORG Ten” I-ORG Project I-ORG of I-ORG the I-ORG Department I-ORG of I-ORG Education I-ORG of I-ORG Guangdong I-ORG Province I-ORG of I-ORG China O the O Basic O and O Applied O Research O Major O Projects O of O Guangdong O Province O of O China O 2017KZDXM035 O and O 2018KZDXM036 B-AWARD the O “Yang B-ORG Fan” I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG of I-ORG China I-ORG Andy O T. I-AWARD Y. I-AWARD Lau-2016 I-AWARD and O Yan-Ming B-AWARD Xu-2015 O and O the O Shantou B-ORG Medical I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG 200624165260857 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51807136 O 51537008 I-AWARD and I-AWARD U1966203 O Project O supported O by O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Power I-ORG Transmission I-ORG Equipment I-ORG and I-ORG System I-ORG Security I-ORG SKLD19KM08 O National B-ORG Postdoctoral I-ORG Program I-ORG for I-ORG Innovative I-ORG Talents I-ORG BX201700168 O This O study O is O supported O by O Beijing B-ORG Talents I-ORG Project I-ORG Funding I-ORG for I-ORG High-level I-ORG Talents I-ORG in I-ORG Beijing I-ORG Municipal I-ORG Health I-ORG System I-ORG 2014-3-088 O WL O National B-ORG Major I-ORG Scientific I-ORG Instruments I-ORG and I-ORG Equipment I-ORG Development I-ORG Project I-ORG ZDYZ2015-2 O JZ O Beijing B-ORG You’an I-ORG Hospital I-ORG Hepatic I-ORG Disease I-ORG I-ORG HIV I-ORG Fund I-ORG 20150203 O JZ O The O fundings O had O no O role O in O the O study O design O collection O analysis O and O interpretation O of O data O writing O of O the O manuscript O or O the O decision O to O submit O the O manuscript O for O publication O The O current O study O was O supported O by O the O Young B-ORG Fund I-ORG of I-ORG the I-ORG Shanghai I-ORG Municipal I-ORG Health I-ORG Commission I-ORG 20194Y0443 O the O Dietary B-ORG Nutrition I-ORG Research I-ORG and I-ORG Education I-ORG Foundation I-ORG of I-ORG the I-ORG Danone I-ORG Nutrition I-ORG Center I-ORG DIC2019-03 O outstanding B-ORG young I-ORG talents I-ORG in I-ORG the I-ORG Shanghai I-ORG municipal I-ORG public I-ORG health I-ORG system’s I-ORG three-year I-ORG plan I-ORG 2020–2022 O GWV-10.3-YQ22 O an B-ORG academic I-ORG leader I-ORG in I-ORG the I-ORG Shanghai I-ORG municipal I-ORG public I-ORG health I-ORG system’s I-ORG three-year I-ORG plan I-ORG 2020-2022 O GWV-10.2-XD18 O and O key B-ORG disciplines I-ORG in I-ORG the I-ORG Shanghai I-ORG municipal I-ORG public I-ORG health I-ORG system’s I-ORG three-year I-ORG plan I-ORG 2020-2022 O GWV-10.1-XK11 O This O research O was O funded O by O the O support O provided O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 51507081 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG KJQN201623 O and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0700800 O This O work O was O funded O by O the O Jilin B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Projects I-ORG 20190303120SF O Jilin B-ORG Province I-ORG Key I-ORG Technology I-ORG R&D I-ORG Project I-ORG 20180101212NY O and O Changchun B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 18DY023 O This O study O was O supported O in O part O by O Jiangsu B-ORG Province I-ORG Natural I-ORG Science I-ORG Foundation I-ORG BK20151584 O Jiangsu B-ORG Top I-ORG Expert I-ORG Program I-ORG in I-ORG Six I-ORG Professions I-ORG WSW-028 O and O Jiangsu B-ORG Province I-ORG key I-ORG research I-ORG and I-ORG development I-ORG plan I-ORG BE2016789 O This O study O was O supported O by O the O non-profit B-ORG organization I-ORG Fördergemeinschaft I-ORG Deutsche I-ORG Kinderherzzentren I-ORG grant O number O W-B-016/2016 B-AWARD The O Competence O Network O for O Congenital O Heart O Defects O received O funding O from O the O German B-ORG Federal I-ORG Ministry I-ORG of I-ORG Education I-ORG and I-ORG Research O grant O number O 01GI0601 B-AWARD until O 2014 O and O the O DZHK O German O Centre O for O Cardiovascular O Research O as O of O 2015 O Reference O data O from O the O MoMo O Study O The O MoMo O Study O is O funded O by O the O Federal O Ministry O of O Education O and O Research O funding O reference O number O 01ER1503 B-AWARD within O the O research O program O ´long-term O studies O in O public O health O research O This O work O was O supported O by O the O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2021YFD1401100 O the O Jiangsu B-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Independent I-ORG Innovation I-ORG Fund I-ORG CX(22)3018 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31871965 O 32072395 B-AWARD and O the O China B-ORG Scholarship I-ORG Council I-ORG 202003250119 O The O article O processing O charge O APC O was O funded O by O Ministry B-ORG of I-ORG Education I-ORG grant O number O 3500-1205080302 B-AWARD This O research O was O funded O by O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG the I-ORG People’s I-ORG Republic I-ORG of I-ORG China I-ORG grant O number O 0001-56105602 B-AWARD and O Capital B-ORG Medical I-ORG University I-ORG grant O number O PYZ2017107 B-AWARD XSKY202105 B-AWARD XSKY2015060 B-AWARD This O work O was O supported O by O Samsung B-ORG Research O Funding O Center O of O Samsung O Electronics O No. O SRFC-IT1901-06 O and O by O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea(NRF O grant O funded O by O the O Korea O government(MSIT O No. O 2019R1C1C1008462 O The O present O research O has O been O conducted O by O the O Research O Grant O of O Kwangwoon B-ORG University I-ORG in O 2020 B-AWARD Országos B-ORG Tudományos I-ORG Kutatási I-ORG Alapprogramok I-ORG HU) I-ORG Grant O Nos O F5254 B-AWARD T29703 I-AWARD and I-AWARD A08-1-2009-0051 I-AWARD funded O field O observation O design O data O acquisition O data O managament O analysis O and O preparing O the O publication O Nemzeti B-ORG Kutatási I-ORG és I-ORG Fejlesztési I-ORG Program I-ORG HU) I-ORG Grant O Nos O NKFP B-AWARD 3B-0008/2002 I-AWARD and I-AWARD NKFP I-AWARD 6-0013/2005 I-AWARD funded O data O acquisition O and O managament O Sixth B-ORG Framework I-ORG Programme I-ORG BE) O GOCE-CT-2003-505298 B-AWARD funded O data O acquisition O and O managament O LIFE B-ORG Programme I-ORG BE) I-ORG Grant O No. O LIFE08 B-AWARD ENV/IT/000399 I-AWARD funded O data O acquisition O and O managament O Seventh B-ORG Framework I-ORG Programme I-ORG BE) O FP7-262060 B-AWARD funded O data O acquisition O and O managament O Gazdaságfejlesztési B-ORG és I-ORG Innovációs I-ORG Operatív I-ORG Program I-ORG HU) I-ORG GINOP B-AWARD 2.3.3-15-2016-00019 I-AWARD funded O preparing O the O publication O This O research O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 21905069 B-AWARD U21A20307 B-AWARD the O Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Committee I-ORG Nos O ZDSYS20190902093220279 B-AWARD KQTD20170809110344233 B-AWARD GXWD20201230155427003-20200821181245001 B-AWARD GXWD20201230155427003-20200821181809001 B-AWARD and O ZX20200151 B-AWARD the O Department B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2020A1515110879 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31900233 O Shandong B-ORG Key I-ORG R&D I-ORG Program I-ORG 2019GSF107088 O the O Outstanding B-ORG Youth I-ORG Innovation I-ORG Team I-ORG of I-ORG Shandong I-ORG High I-ORG Universities I-ORG 2019kJe117 O and O the O open O funds O of O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Plant I-ORG Physiology I-ORG and I-ORG Biochemistry I-ORG SKLPPBKF2201 O This O study O was O supported O by O the O National B-ORG High I-ORG Technology I-ORG Research I-ORG Development I-ORG 863 I-ORG Plan I-ORG 2009AA101104 O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 I-ORG 2011CB109306 O the O National B-ORG Cotton I-ORG Industry I-ORG Technology I-ORG System I-ORG CARS-18 O and O the O Scientific B-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Higher I-ORG Education I-ORG Institution I-ORG of I-ORG Xinjiang O China O XJEdu O 2006I59 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O National B-ORG Research I-ORG Foundation O South O Africa O CPRR O grant O number O 118546 B-AWARD IRG—China/South B-ORG Africa I-ORG Research I-ORG Cooperation I-ORG Programme I-ORG Grant O Unique O Number O 132793 B-AWARD We O also O thank O the O financial O support O of O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG International I-ORG Cooperation I-ORG Project I-ORG of I-ORG China I-ORG 2021YFE0106500 O This O study O was O financially O supported O by O the O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG No. O 2015CB453302 O to O SD, O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 40976084 O to O HT O and O the O NSFC-Shandong B-ORG Joint I-ORG Fund I-ORG for I-ORG Marine I-ORG Science I-ORG Research I-ORG Centre I-ORG No. O U1606404 O to O SD. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Anhui I-ORG Province I-ORG No. O 202104f06020005 B-AWARD University B-ORG Youth I-ORG Talent I-ORG Support I-ORG Program I-ORG of I-ORG Anhui I-ORG Province I-ORG No. O gxyq2022024 B-AWARD and O Research B-ORG Projects I-ORG of I-ORG Anhui I-ORG Polytechnic I-ORG University I-ORG No. O Xjky2022081 B-AWARD Xjky2020037 B-AWARD China O This O study O was O funded O by O the O Auckland B-ORG Medical I-ORG Research I-ORG Foundation I-ORG Project O grant O 9101/3709989 B-AWARD and O The B-ORG University I-ORG of I-ORG Auckland I-ORG FRDF O grant I-AWARD 9101/3704255 O AC O was O funded O by O a O Royal B-ORG Society I-ORG of I-ORG New I-ORG Zealand I-ORG Rutherford I-ORG Foundation I-ORG Post-Doctoral I-ORG Research I-ORG Fellowship I-ORG grant O 9101/3709428 B-AWARD This O work O is O supported O in O part O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangxi I-ORG No. O 2021GXNSFAA075005 B-AWARD the O funding O Nos O T3120099202 B-AWARD and O T3120097921 B-AWARD for O the O Bagui B-ORG Talent I-ORG of I-ORG Guangxi I-ORG Province I-ORG Talent I-ORG Model I-ORG Base I-ORG No. O AD19110157 B-AWARD Disinfection B-ORG Robot I-ORG Based I-ORG on I-ORG High I-ORG Power I-ORG AlGaN-based I-ORG UV-LEDs O No. O BB31200014 B-AWARD the O Guangxi B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG No. O AD19245132 B-AWARD the O Guangxi B-ORG University I-ORG Foundation I-ORG No. O A3120051010 B-AWARD and O the O Guangxi B-ORG Science I-ORG and I-ORG Technology I-ORG Base I-ORG and I-ORG Talent I-ORG Special I-ORG Project I-ORG No. O AD20238093 B-AWARD This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31870114 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2018YFD1100503 B-AWARD and O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Urban I-ORG Water I-ORG Resources I-ORG and I-ORG Environment I-ORG Harbin O Institute O of O Technology O No. O 2019DX02 B-AWARD This O work O was O supported O by O ‘Innovation O enhancement O engineering O project O department B-ORG of I-ORG finance I-ORG Sichuan I-ORG province’ O 2016GXTZ-004 O ‘Applied O and O basic O research O department B-ORG of I-ORG science I-ORG and I-ORG technology I-ORG Sichuan I-ORG province’ O 17YYJC0208 O and O ‘Research O thesis O founds O Sichuan B-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences’ O 2017LWJJ-003 O This O work O was O supported O by O the B-ORG Youth I-ORG Medical I-ORG Talent I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG QNRC2016292 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 63, B-AWARD 2018M632371 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grant O Nos O BK20141161 B-AWARD and O BK20150251 B-AWARD We O thank O AJE O for O its O linguistic O assistance O during O the O preparation O of O this O manuscript O This O work O was O supported O by O grants O from O Cancer B-ORG Research I-ORG UK I-ORG A16893 O PS O Medical B-ORG Research I-ORG Council I-ORG MR/M015610/1 O HMK O STARPAC O clinical O trial O is O supported O by O grants O from O Medical O Research O Council O MR/M015610/1 O HMK O and O Celgene B-ORG Sarl O AX-CL-Panc-PI-003922 O HMK O The O funders O had O no O role O in O the O design O of O the O study O or O collection O analysis O or O interpretation O of O data O or O writing O of O the O manuscript O This O work O was O supported O by O the O Sao B-ORG Paulo I-ORG Research I-ORG Foundation I-ORG FAPESP O Grant O Numbers O 2015/50122-0 B-AWARD and I-AWARD 2018/06205-7 O DFG-IRTG B-ORG Grant O Number O 1740/2 B-AWARD CNPq B-ORG Grant O Number O 420338/2018-7 B-AWARD CAPES B-ORG Grant O Number O 23038.014333/2020-46 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81460394 O Shenzhen B-ORG science I-ORG and I-ORG technology I-ORG innovation I-ORG committee I-ORG foundation I-ORG JCYJ20160429172357927 O and O Sanming B-ORG Project I-ORG of I-ORG Medicine I-ORG in I-ORG Shenzhen I-ORG SZSM201406007 O This O work O was O funded O by O Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG China I-ORG Grant O No. O ZR2019BEE036 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2018M642627 B-AWARD National B-ORG Engineering I-ORG Laboratory I-ORG for I-ORG Ultra I-ORG High I-ORG Voltage I-ORG Engineering I-ORG Technology I-ORG Grant O No. O NEL201802 B-AWARD This O work O received O funding O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 22168036 B-AWARD the B-ORG Central I-ORG Government I-ORG Funds I-ORG for I-ORG Local I-ORG Science I-ORG and I-ORG Technological I-ORG Development O No. O XZ202201YD0020C B-AWARD and O Tibet B-ORG University I-ORG Postgraduate I-ORG Students’ I-ORG High-Level I-ORG Talent I-ORG Training I-ORG Plan I-ORG Project I-ORG No. O 2020-GSP-S040 B-AWARD No. O 2020-GSP-S039 B-AWARD This O work O was O supported O by O grants O from O the O São B-ORG Paulo I-ORG Research I-ORG Foundation I-ORG FAPESP O project O numbers O 2018/03917-6 B-AWARD and O 18/10990-1 B-AWARD the O National B-ORG Council I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Development I-ORG CNPq O project O number O 440379/2016-4 B-AWARD the O Coordination B-ORG for I-ORG the I-ORG Improvement I-ORG of I-ORG Higher I-ORG Education I-ORG Personnel I-ORG CAPES O project O number O 88881.130767/2016-01 B-AWARD and O the O Research B-ORG Foundation I-ORG – I-ORG Flanders I-ORG FWO-Vlaanderen O project O number O G0F8822N B-AWARD Ana O Carolina O de O Carvalho O and O Rebeca O F. O Rocha O are O recipients O of O FAPESP B-ORG scholarships I-ORG project O numbers O 2018/02993-0 B-AWARD and O 2018/02594-9 B-AWARD respectively O Maurício O Lacerda O Nogueira O is O partially O supported O by O the O Centers O for O Research O in O Emerging O Infectious O Disease O via O The O Coordinating O Research O on O Emerging O Arboviral O Threats O Encompassing O the O Neotropics O CREATE-NEO O grant O U01AI151807 B-AWARD awarded O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH/USA O MLN O and O REM O are O CNPq O Research O Fellows O OBH O and O MCJM O are O funded O by O the O Wellcome B-ORG Trust I-ORG 087622/Z/08/2 O and O the O Oxford O Martin O School O KAJ O and O JEB O are O funded O by O Wellcome B-ORG Trust I-ORG Biomedical I-ORG Resource I-ORG Grant O 104992 O CS O is O funded O by O the O German B-ORG Research I-ORG Foundation I-ORG DFG O grant O SCHO1322/1 O XW O and O ACR O are O supported O by O the O CDC O The O study O has O been O funded O by O a O Spanish B-ORG Ministry I-ORG of I-ORG Science I-ORG grant I-ORG project I-ORG CGL2012-39953-C02-01 O IM O received O funding O from O the O People O Programme O Marie O Curie O Actions O of O the O European B-ORG Union’s I-ORG Seventh I-ORG Framework I-ORG Programme I-ORG FP7/2007–2013 O under O REA B-ORG grant I-ORG agreement I-ORG PIOF-GA-2011-301257 B-AWARD VS O was O funded O by O a O Tomsk O State O University O TSU O Russia O PhD O fellowship O PC O and O IM O were O partially O funded O by O a O Bioflora O grant O cofunded O by O the O Spanish O Aragon O Government O and O the O European O Social O Fund O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O ISCIIII-FEDER B-ORG and O ISCIII-RETICS B-ORG REDinREN B-ORG grant O numbers O PI17/00257 B-AWARD PI21/01292 B-AWARD RICORS B-AWARD RD21/0005/0016 O Marató B-ORG TV3 I-ORG 2020 I-ORG 421/C/2020 B-AWARD Marató B-ORG TV3 I-ORG 2021 I-ORG 215/C/2021 B-AWARD and B-ORG ERA-PerMed-JTC I-ORG 2022 I-ORG ONAKI-ICI B-AWARD AC22/00029 I-AWARD This O work O was O supported O by O Russian B-ORG Foundation I-ORG for I-ORG Basic I-ORG Research,http://www.rfbr.ru/rffi/ru O 17-54-12041-NNIO B-AWARD Dr. O Alexander O Averianov O Deutsche B-ORG Forschungsgemeinschaft,http://www.dfg.de O MA B-AWARD 1643/22-1 I-AWARD Prof O Thomas O Martin O Zoological B-ORG Institute I-ORG Russian I-ORG Academy I-ORG of I-ORG Sciences O АААА-А17-117022810195-3 B-AWARD Dr. O Alexander O Averianov O and O Program O of O the O Russian O Academy O of O Sciences O Presidium O Evolution O of O the O organic O world O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21703114 O 51773102 O Key B-ORG Research I-ORG Project I-ORG of I-ORG Shandong I-ORG Province I-ORG 2018GGX102011 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2016BP03 O and O Foundation O of O Qingdao O University O 41117010117 O Financial O support O for O this O project O was O provided O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grants O 31770476 B-AWARD and O 314704651 B-AWARD Publication O costs O were O funded O by O the B-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-32 O In O addition O graduate O student O salary O and O tuition O support O was O provided O by O the O Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG for I-ORG Chinese I-ORG Academy I-ORG of I-ORG Tropical I-ORG Agricultural I-ORG Sciences I-ORG 1630052019020 O The O funding O bodies O had O no O role O in O the O design O of O the O study O and O no O role O in O the O collection O analysis O and O interpretation O of O data O or O in O writing O the O manuscript O This O work O was O supported O by O the B-ORG Guangdong I-ORG Province I-ORG Key I-ORG Field I-ORG R&D I-ORG Program I-ORG Project I-ORG 2020B090922004 O the B-ORG Wuyi I-ORG University I-ORG Scientific I-ORG Research I-ORG Foundation I-ORG AL2018011 O 2019AL009 B-AWARD and O 2018TP013 B-AWARD the B-ORG Jiangmen I-ORG City I-ORG Fundamental I-ORG and I-ORG Applied I-ORG Fundamental I-ORG Research I-ORG Fund I-ORG 2020030102130005402 O the B-ORG Guangdong-Hong I-ORG Kong-Macao I-ORG Joint I-ORG Research I-ORG and I-ORG Development I-ORG Fund I-ORG of I-ORG Wuyi I-ORG University I-ORG 2019WGALH22 O the B-ORG Wuyi I-ORG University I-ORG Joint I-ORG Training I-ORG Postgraduate I-ORG Demonstration I-ORG Base I-ORG Fund I-ORG 503170060251 O and O the B-ORG Key I-ORG Technology I-ORG Research I-ORG projects I-ORG in I-ORG Inner I-ORG Mongolia I-ORG Autonomous I-ORG Region I-ORG 2021GG0274 O This O work O was O supported O by O grants O from O the O INSERM O French O National O Institute O for O Health O and O Medical O Research O the O French O Ministry O of O Higher O Education O Research O and O Innovation O the O Foundation B-ORG for I-ORG Medical I-ORG Research I-ORG FRM/N°DEQ20140329555 O and O the O Regional O Council O of O Lower O Normandy O This O project O is O also O part O of O the O following O European O research O programs O 1/ O European B-ORG Marie I-ORG Curie I-ORG International I-ORG Training I-ORG Network I-ORG “NeuroInflammation O FP7 B-AWARD 2/ O NeuroAtlantic B-ORG An I-ORG Atlantic I-ORG innovation I-ORG platform I-ORG on I-ORG diagnosis I-ORG and I-ORG treatment I-ORG of I-ORG neurological I-ORG diseases I-ORG and I-ORG aging O EAPA_791/2018-NEUROATLANTIC B-AWARD 3/ O H2020 B-ORG International I-ORG Marie I-ORG Curie I-ORG Training I-ORG Network I-ORG ENTRAIN I-ORG Neuroinflammation O H2020-MSCA-ITN-2018 B-AWARD number I-AWARD 813294 I-AWARD This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0100600 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31571944 O and O the O Young B-ORG Elite I-ORG Scientist I-ORG Sponsorship I-ORG of I-ORG China I-ORG Association I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG 2015QNRC001 O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2020YFA0711700 B-AWARD and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 12002303 B-AWARD and O ZJU-ZCCC B-ORG Institute I-ORG of I-ORG Collaborative I-ORG Innovation I-ORG No. O ZDJG2021002 B-AWARD The O authors O have O benefited O from O the O communication O with O Guannan O Wang O of O Zhejiang O University O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 I-ORG Program I-ORG 2011CB505300 O 2011CB505303 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81603258 O 333 B-ORG High-level I-ORG Talents I-ORG Training I-ORG Project I-ORG Funded I-ORG by I-ORG Jiangsu I-ORG Province I-ORG BRA2016387 O and O the B-ORG Priority I-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O This O study O was O jointly O supported O by O the O National O R&D O Plan O of O China O 2017YFC0803906 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 51408049 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG funded O project O Grant O No. O 2016M590914 B-AWARD the O Shaanxi B-ORG Postdoctoral I-ORG Science I-ORG Research I-ORG project I-ORG Grant O No. O 2016BSHEDZZ134 B-AWARD and O the O Open O Foundation O Projects O of O the O State O Key O Laboratory O of O Road O Engineering O Safety O and O Health O in O Cold O and O High-Altitude O Regions O Grant O No. O YGY2017KYPT-01 B-AWARD This O study O was O partially O supported O by O grants O from O the O Spanish B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Innovation I-ORG SAF2017-84267-R O Xunta B-ORG de I-ORG Galicia I-ORG Consellería O Educación O IN607A2018/3 B-AWARD Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III I-ORG ISCIII O PI17/00540 O and O PI17/01103 B-AWARD Spanish O Research O Network O on O Cerebrovascular O Diseases O RETICS-INVICTUS O PLUS O RD16/0019 O and O by O the O European O Union O FEDER O program O Furthermore O Tomás O Sobrino O CPII17/00027 O and O Francisco O Campos O CPII19/00020 O are O recipients O of O research O contracts O from O the O Miguel O Servet O Program O of O Instituto O de O Salud O Carlos O III O María O Pérez-Mato O is O a O Sara O Borrell O Researcher O CD19/00033 O The O sponsors O did O not O participate O in O the O study O design O collection O analysis O or O interpretation O of O the O data O writing O the O report O or O in O the O decision O to O submit O the O paper O for O publication O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31872407 B-AWARD Major B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Inner I-ORG Mongolia I-ORG No. O 2019ZD008 B-AWARD and O Foundation B-ORG for I-ORG High-level I-ORG Talents I-ORG of I-ORG Inner I-ORG Mongolia I-ORG University I-ORG No. O 12000-15031908 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O No. O 61906159 B-AWARD in O part O by O the O Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG under O Grant O No. O 2018JY0607 B-AWARD in O part O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG under O Grant O No. O JBK1901030 B-AWARD No. O JBK1801080 B-AWARD This O work O was O supported O by: O 1. O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG High I-ORG Efficient I-ORG Ground I-ORG and I-ORG Aerial I-ORG Spraying I-ORG Technology I-ORG and I-ORG Intelligent I-ORG Equipment I-ORG China O grant O number O 2016YFD0200700;http://service.most.gov.cn/2015tztg_all/20160622/1108.html B-AWARD funding O institution O Ministry O of O Agriculture O of O the O People's O Republic O of O China O the O author O receiving O the O funding O Yubin O Lan O role O of O funder O in O this O study O study O design O decision O to O publish O 2: O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG China O grant O number O 2017A020208046;http://www.gdstc.gov.cn B-AWARD funding O institution O Department O of O Science O and O Technology O of O Guangdong O Province O China O the O author O receiving O the O funding O Jizhong O Deng O role O of O funder O in O this O study O study O design O decision O to O publish O 3: O The B-ORG National I-ORG Natural I-ORG Science I-ORG Fund I-ORG China O grant O number O 61675003;http://www.nsfc.gov.cn/publish/portal0 B-AWARD funding O institution O National O Natural O Science O Foundation O of O China O the O author O receiving O the O funding O Xiaoling O Deng O role O of O funder O in O this O study O study O design O preparation O of O the O manuscript O This O work O was O supported O by O the O Spanish O Ministry O for O Economy O and O Competitiveness O formerly O known O as O Innovation O and O Science O with O the O projects O IBERYCA B-ORG CGL2017-84723-P O VERONICA B-ORG CGL2013-42271-P O and O MyFUNCO B-ORG CGL2011-29585-C02-02 O and O the O project O REMEDINAL B-ORG 3-CM I-ORG ref O S2013/MAE-2719 B-AWARD funded O by O the O Comunidad O de O Madrid O Dulce O Flores-Rentería O holds O a O pre-doctoral O fellowship O awarded O by O the O Mexican O Council O of O Science O and O Technology O CONACyT O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O in O part O by O a O grant O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81302144 O and O the O Guangdong B-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG 2012B061700087 O and O Guangzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG key I-ORG projects I-ORG 201508020247 O This O work O was O supported O by O the O Scientific B-ORG and I-ORG Technological I-ORG Innovation I-ORG Project I-ORG Financially I-ORG Supported O by O Qingdao O National O Laboratory O for O Marine O Science O and O Technology O No. O 2016ASKJ14 B-AWARD the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG grant O number O XDA11030202 B-AWARD the O NSFC–Shandong B-ORG Joint I-ORG Fund I-ORG for I-ORG Marine I-ORG Ecology I-ORG and I-ORG Environmental I-ORG Sciences I-ORG grant O number O U1406403 B-AWARD and O the O Innovation B-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG International I-ORG Partnership I-ORG Project I-ORG Team I-ORG grant O number O 20140491526 B-AWARD This O study O is O partly O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81972324 B-AWARD the O China B-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG Grant O No. O 2016-I2M-3-019 B-AWARD and O by O the B-ORG non-profit I-ORG Central I-ORG Research I-ORG Institute I-ORG Fund I-ORG of I-ORG Chinese I-ORG of I-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG Grant O No. O 2018PT32014 B-AWARD This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG 2016YFA0601102 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31570099 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG 19ZR1475500 O This O work O was O supported O by O Brazilian O grants O from O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq I-ORG grant I-ORG call I-ORG Universal I-ORG #405027/2021-4 O 427946/2018-2 B-AWARD CNPq B-ORG senior I-ORG research I-ORG fellowship I-ORG #309633/2021-4 O 307852/2019-9 B-AWARD Fundação B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG do I-ORG Ensino I-ORG Superior I-ORG Particular I-ORG FUNADESP O grant O number O 5301159 B-AWARD research O fellowship O PPSUS O grant O funded O by O Decit/SCTIE/MS B-ORG intermediated I-ORG by I-ORG CNPq I-ORG with O support O of O Fundação O Araucária O and O SESA-PR O agreement O 041/2017 B-AWARD PRONEX O grant O supported O by O SETI/Fundação B-ORG Araucária I-ORG and I-ORG MCTI/CNPq I-ORG and I-ORG Governo I-ORG do I-ORG Estado I-ORG do I-ORG Paraná I-ORG agreement O 014/2017 B-AWARD and O CAPES B-ORG finance O code O 001 B-AWARD This O work O was O supported O in O part O by O grants O from O Kaohsiung B-ORG Armed I-ORG Forces I-ORG General I-ORG Hospital I-ORG Zuoying I-ORG Branch I-ORG ZAFGH105-10 O the O Ministry B-ORG of I-ORG Health I-ORG and I-ORG Welfare I-ORG MHW-10347 O and O Kaohsiung B-ORG Veterans I-ORG General I-ORG Hospital I-ORG Taiwan I-ORG VGHKS105-134 O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG Grant O Number O 14ZR1438700 B-AWARD the O National B-ORG Basic I-ORG Research I-ORG Programme I-ORG of I-ORG China I-ORG 973 O programme O Grant O Number O 2015CB554501 B-AWARD and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Number O 81473758 B-AWARD This O work O was O supported O by O theMedical O Research I-ORG CouncilGrant O MR/K00414X/1 B-AWARD andArthritis O Research I-ORG UK, I-ORG ARUK)Grant O 19891 B-AWARD as O part O of O the O MRC-ARUK O Centre O for O Musculoskeletal O Ageing O Research,The O Dunhill I-ORG Medical I-ORG TrustGrant O R364/1112 B-AWARD to O KS, O PJA O DJW O MVN O O JPW O and O the O Physiological O Society O awarded O to O PJA O O KS O This O work O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81602492 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFA0201402 O and O by O the O National B-ORG Major I-ORG Scientific I-ORG and I-ORG Technological I-ORG Special I-ORG Project I-ORG for I-ORG “Significant I-ORG New I-ORG Drugs I-ORG Development” I-ORG No. O 2018ZX09733001 O This O study O was O supported O by O The O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2018YFB1600902 B-AWARD to O YP, O The O MOE B-ORG Layout I-ORG Foundation I-ORG of I-ORG Humanities I-ORG and I-ORG Social I-ORG Sciences I-ORG No. O 18YJAZH009 B-AWARD to O GC O and O The O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51778063 B-AWARD to O LX. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O in O part O by O the O GRMH-GDL B-ORG Start-up I-ORG Research I-ORG Grant I-ORG 1101201204 O to O H.W O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81770158 O to O C.Z O and O the O Pearl B-ORG River I-ORG S&T I-ORG Nova I-ORG Program I-ORG of I-ORG Guangzhou O China O 201906010002 O to O C.Z O The O work O of O K-FX O and O XT O was O supported O by O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81570061 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0901502 O the O Beijing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG Z151100003915126 O and O the O Chinese B-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG CAMS I-ORG Initiative I-ORG for I-ORG Innovative I-ORG Medicine I-ORG 2017-12M-2-001 O This O work O was O supported O by O the B-ORG Consulting I-ORG Service I-ORG for I-ORG Center I-ORG of I-ORG Excellence I-ORG in I-ORG Global I-ORG Health I-ORG Policy I-ORG Development I-ORG and I-ORG Governance I-ORG in I-ORG China I-ORG GHSP-CS-OP3-02 O the B-ORG Three-year I-ORG Action I-ORG Plan I-ORG on I-ORG Public I-ORG Health I-ORG Phase I-ORG IV, I-ORG Shanghai I-ORG China I-ORG 15GWZK0801 O and O the B-ORG National I-ORG Key I-ORG R I-ORG I-ORG D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC09070000 O The O funders O had O no O role O in O study O design O preparation O and O decision O to O publish O of O the O manuscript O This O work O is O finically O supported O by O the O Project O of O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O grant O nos O 61705138 B-AWARD 61675137 B-AWARD Guangdong B-ORG Natural I-ORG Science I-ORG Foundation I-ORG grant O nos O 2017A030310033 B-AWARD Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Commission I-ORG of I-ORG Shenzhen I-ORG grant O nos O JCYJ20170818093743767 B-AWARD JCYJ20160307143716576 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG grant O no. O 2016M600669 B-AWARD Development O and O Reform O Commission O of O Shenzhen O Municipality O Foundation O This O work O was O supported O by O the B-ORG Special I-ORG Fund I-ORG for I-ORG Health-scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG of I-ORG China I-ORG Program I-ORG 201002021 O to O Yu-Xing O Ni, O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81472010 O to O Yu-Xing O Ni O and O the B-ORG Shanghai I-ORG Three-Year I-ORG Plan I-ORG of I-ORG the I-ORG Key I-ORG Subjects I-ORG Construction I-ORG in I-ORG Public I-ORG Health-Infectious I-ORG Diseases I-ORG and I-ORG Pathogenic I-ORG Microorganism I-ORG 15GWZK0102 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O preparation O of O the O manuscript O or O decision O for O publication O This O research O was O funded O by O the O National B-ORG Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute I-ORG NHLBI O grants O HL095701 B-AWARD S.A.P O and O the O American B-ORG Heart I-ORG Association O grant O 20POST35120466 B-AWARD C.-L.H O The O project O described O was O supported O by O the O National B-ORG Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences O National O Institutes O of O Health O through O Grant O UL1TR002003 B-AWARD This O work O was O supported O by O the O Wellcome B-ORG Trust I-ORG 106698 O the O Asian B-ORG Development I-ORG Bank I-ORG TA-8763 O the O Bill B-ORG and I-ORG Melinda I-ORG Gates I-ORG Foundation I-ORG BMGF O OPP1089413 O and O the O Department B-ORG of I-ORG Foreign I-ORG Affairs I-ORG and I-ORG Trade I-ORG Australian I-ORG Government I-ORG 71215 O This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG China I-ORG 2021YFA1000102 O and O 2021YFA1000103 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 61873280 B-AWARD 61972416 B-AWARD 62272479 B-AWARD 62202498 B-AWARD Taishan B-ORG Scholarship I-ORG tsqn201812029 O Foundation B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG of I-ORG Jinan I-ORG 201907116 O Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG ZR2021QF023 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 21CX06018A O Spanish B-ORG project I-ORG PID2019-106960GB-I00 B-AWARD Juan B-ORG de I-ORG la I-ORG Cierva I-ORG IJC2018-038539-I B-AWARD All O authors O are O funded O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH/NIAID O Grant O R01AI103629 B-AWARD E.M.L O C.C.K O and O L.N O are O also O funded O by O the O ME B-ORG Association I-ORG Grant O PF8947_ME B-AWARD Association O T.G.C O is O also O funded O by O the O Medical B-ORG Research I-ORG Council I-ORG UK O Grants O MR/K000551/1 B-AWARD MR/M01360X/1 B-AWARD MR/N010469/1 B-AWARD and O MC_PC_15103 B-AWARD The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O National O Institutes O of O Health O This O research O received O funds O from O CN00000041 O “National O Center O for O Gene O Therapy O and O Drugs O based O on O RNA O Technology” O funded O by O the B-ORG European I-ORG Union I-ORG NextGenerationEU I-ORG and O financed O by O PNRR B-AWARD MUR-M4C2—Investimento O 1.4 O CUP B-ORG UNINA O E63C22000940007 B-AWARD M. O Terracciano O acknowledges O financial O support O from O PON-AIM B-ORG RTDA_L1 I-ORG AIM O 1873131-2 O S. O Račkauskas O acknowledges O funding O from O the O European B-ORG Regional I-ORG Development I-ORG Fund I-ORG project O No. O 01.2.2-LMT-K-718-02-0011 B-AWARD under O a O grant O agreement O with O the O Research O Council O of O Lithuania O LMTLT O Sjors O Overman O would O like O to O acknowledge O funding O received O for O this O project O from O the O Netherlands B-ORG Organisation I-ORG for I-ORG Scientific I-ORG Research I-ORG NWO O as O part O of O the O NWO‐vidi O project O “Calibrating O Public O Accountability” O 452‐14‐008 O Madalina O Busuioc O would O like O to O acknowledge O funding O received O for O this O project O from O the O European B-ORG Research I-ORG Council I-ORG ERC O under O the O European O Union's O Horizon O 2020 O research O and O innovation O program O grant O agreement O 716439 B-AWARD Matthew O Wood O would O like O to O acknowledge O funding O received O for O this O project O from O the O Economic B-ORG and I-ORG Social I-ORG Research I-ORG Council I-ORG ESRC O grant O number O ES/L010925/1 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O no. O 11402153 B-AWARD and O the O Talent B-ORG Introduction I-ORG Scientific I-ORG Research I-ORG Projects I-ORG Funded I-ORG Start-Up I-ORG Funds I-ORG No. O 2082204174089 B-AWARD and O the O Excellent B-ORG Young I-ORG Scientist I-ORG Foundation I-ORG No. O 2082604184338 B-AWARD of O Sichuan O University O of O China O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O design O of O the O article O was O inspired O by O the O Beijing B-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospital I-ORG Youth I-ORG Program I-ORG QML20171901 O project O The O cost O of O authors O participating O in O the O meta-analysis O methodology O training O is O funded O by O the O Beijing O Municipal O Administration O of O Hospital O Youth O Program O QML20171901 O and O Beijing B-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospitals I-ORG Clinical I-ORG Medicine I-ORG Development I-ORG of I-ORG Special I-ORG Funding I-ORG Support I-ORG ZYLX201807 O project O and O writing O training O is O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81901355 O and O Beijing B-ORG Municipal I-ORG Natural I-ORG Science I-ORG Foundation I-ORG 7192081 O No O investigator O benefited O from O participating O in O the O study O This O work O is O supported O by O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG LY19H080009 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grants O 81470305-H0812 O U1404806 B-AWARD University B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Talent I-ORG Support I-ORG Program I-ORG of I-ORG Henan I-ORG Province I-ORG 17HASTIT046 O This O work O was O supported O by O the O Medical B-ORG Research I-ORG Council I-ORG MC_UU_12013/4 B-AWARD and I-AWARD MC_UU_12013/8 O This O work O was O also O supported O by O the O following O grants O 1R01MH101244-02 B-AWARD Statistical O methods O for O studies O of O rare O variants O and O 1R01MH107649-01 B-AWARD Methods O for O linking O GWAS O peaks O to O function O in O psychiatric O disease O D.M.E O is O supported O by O an O Australian O Research O Council O Future O Fellowship O FT130101709 O This O work O was O in O part O supported O by O Cancer B-ORG Research I-ORG UK I-ORG programme I-ORG grant O number O C18281/A19169 B-AWARD the O Integrative O Cancer O Epidemiology O Programme O P.H O is O a O Cancer B-ORG Research I-ORG UK I-ORG Population I-ORG Research I-ORG Fellow O grant O number O C52724/A20138 B-AWARD This O work O was O supported O by: O Fondo B-ORG di I-ORG ateneo I-ORG per I-ORG la I-ORG ricerca I-ORG di I-ORG base O ORSA229281 B-AWARD to O E.C O and O A.A.P O research O funding O from O PRIN B-ORG 2020YRETTX_001 B-AWARD to O A.A.P O Cariplo B-ORG Foundation I-ORG n.2016-0874 O to O A.A.P O Ministry B-ORG of I-ORG Health I-ORG RF-2016-02364864 O to O A.A.P O This O study O was O funded O by O the B-ORG National I-ORG Key I-ORG Technologies I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG during I-ORG the I-ORG 11th I-ORG and I-ORG 12th I-ORG Five I-ORG Year I-ORG Plan I-ORG Period I-ORG 2008ZX1002-006 O 2012ZX10002007-001-040 B-AWARD and O 2013ZX10002004-002-003 B-AWARD Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG 10411955300 O and O 09XD1403200 B-AWARD Shanghai B-ORG Municipal I-ORG Health I-ORG Bureau I-ORG XBR2011012 O This O work O was O supported O by O NHC B-ORG Key I-ORG Laboratory I-ORG of I-ORG Birth I-ORG Defects I-ORG and I-ORG Reproductive I-ORG Health I-ORG 2020cstc-jxj1-01703 O the B-ORG Key I-ORG Project I-ORG of I-ORG Chongqing I-ORG Natural I-ORG Science I-ORG Foundation I-ORG cstc2020jcyj-zdxmX0011 O and O the B-ORG General I-ORG Program I-ORG of I-ORG Chongqing I-ORG Natural I-ORG Science I-ORG Foundation I-ORG cstc2020jcyj-msxmX0012 O This O research O was O carried O out O within O the O National O Biodiversity O Future O Center O S.c.a.r.l O Piazza O Marina O 61 O c/o O Palazzo O Steri O Palermo O Italy O and O received O funding O from O the O European B-ORG Union I-ORG Next-Generation I-ORG EU I-ORG PIANO O NAZIONALE O DI O RIPRESA O E O RESILIENZA O PNRR)—MISSIONE O 4 O COMPONENTE O 2, O INVESTIMENTO O 1.4 O C.I O CN00000033)—CUP B-AWARD UNIPA I-ORG B73C22000790001 B-AWARD CUP B-ORG UNISA I-ORG D43C22001260001 B-AWARD This O work O was O supported O by O the O following O projects O “Hantavirus O Ecology O and O Disease O in O Chile” O grant O National B-ORG Institute I-ORG of I-ORG Health—ICIDR O 1 I-AWARD U19 I-AWARD AI45452-01 I-AWARD Eduardo O Palma O DIUC B-ORG grant O 213.113.85-1AP B-AWARD Enrique O Rodríguez-Serrano O FONDECYT B-ORG grants O 1130467–1170761 B-AWARD Eduardo O Palma O 1140692–1170815 B-AWARD Cristian O E. O Hernandez O and O 1170486 B-AWARD Enrique O Rodríguez-Serrano O and O by O CONICYT B-ORG Magister I-ORG National I-ORG scholarship O year O 2015 O O 22150880 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O project O was O financially O supported O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG project O No. O XDJK2019B003 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG project O No. O 51601154 B-AWARD 51871036 B-AWARD and O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Solidification I-ORG Processing I-ORG in I-ORG NPU O Grant O No. O SKLSP201920 B-AWARD The O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31660649 B-AWARD Guangxi B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG GKAA16450002 O and O Guangxi B-ORG Natural I-ORG Fund I-ORG program I-ORG 2017GXNSFAA198108 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81902962 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2019M653224 O the O Planned O Science O and O Technology O Project O of O Guangdong O Province O 2019B020230002 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017A030312003 O National O Natural O Science O Foundation O of O China O 81803049 O Health O O Medical O Collaborative O Innovation O Project O of O Guangzhou O City O China O 201803040003 O Innovation O Team O Development O Plan O of O the O Ministry O of O Education O No. O IRT_17R110 O This O research O was O supported O by O the O Peking B-ORG University I-ORG People's I-ORG Hospital I-ORG Research I-ORG and I-ORG Development I-ORG Fund I-ORG RDB2009-44 O Shangdong B-ORG Province I-ORG Young I-ORG and I-ORG Middle-Aged I-ORG Scientists I-ORG Research I-ORG Awards I-ORG Fund I-ORG No.BS2014YY060 O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 O Program I-AWARD 2011CB510200).http://www.most.gov.cn/tztg/201010/W020101021511061090978.pdf O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81101280 B-AWARD by O the O National B-ORG Special I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG for I-ORG Major I-ORG Infectious I-ORG Diseases I-ORG of I-ORG China I-ORG Grant O Nos O 2012ZX10004-220 B-AWARD 2016ZX10004222-004 O the O China B-ORG UK I-ORG Global I-ORG Health I-ORG Support I-ORG Programme I-ORG GHSP-CS-OP101 O the O Forth B-ORG Round I-ORG of I-ORG Three-Year I-ORG Public I-ORG Health I-ORG Action I-ORG Plan I-ORG of I-ORG Shanghai I-ORG China(No O 15GWZK0101 B-AWARD GWIV-29 O High O Resolution O Remote O Sensing O Monitoring O Progect O No. O 10-Y30B11-9001-14/16 O The O open O project O from O Key O Laboratory O of O Parasite O and O Vector O Biology O Ministry O of O Health O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O Jiangsu B-ORG Collaborative I-ORG Innovation I-ORG Center I-ORG of I-ORG Chinese I-ORG Medicinal I-ORG Resources I-ORG Industrialization I-ORG Grant O No. I-AWARD ZDXM-HT-1-5 I-AWARD and I-AWARD ZDXM-3-24 O the O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG ysxk-2014 O and O 2017 B-ORG Chinese I-ORG Medicine I-ORG Public I-ORG Health I-ORG Service I-ORG Subvention I-ORG Special I-ORG National I-ORG traditional I-ORG Chinese I-ORG Medicine I-ORG Resource I-ORG Survey I-ORG Project I-ORG Caishe O 2017 I-AWARD 66 O Jin-Ao O Duan O was O the O host O of O the O above-mentioned O four O projects O This O research O was O also O supported O by O the O National O Natural O Science O Foundation O of O China(Grant O No. O 81573520 O and O Jianguo O Chao O was O the O host O of O this O project O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.91959114 O 81872106 B-AWARD 82272804 B-AWARD to O Yang O Zhao O and O No.81970270 O to O Tong O Liu O the O Scientific B-ORG and I-ORG Technological I-ORG Research I-ORG Program I-ORG of I-ORG Tianjin I-ORG Municipal I-ORG Education I-ORG Commission I-ORG No.2021YJSB278 O to O Yunpeng O Zhang O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Tianjin I-ORG No.19JCZDJC33900 O to O Yang O Zhao O Tianjin B-ORG Science I-ORG Fund I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG No.20JCJQJC00270 O to O Yang O Zhao O Scientific B-ORG and I-ORG Technological I-ORG Research I-ORG Program I-ORG of I-ORG Tianjin I-ORG Health I-ORG Commission I-ORG No.TJWJ2022XK015 O to O Yang O Zhao O and O the O Tianjin B-ORG Key I-ORG Medical I-ORG Discipline I-ORG Specialty I-ORG Construction I-ORG Project O No.TJYXZDXK-029A O TJYXZDXK-070C B-AWARD The O APC O was O funded O by O 91959114 O 2021YJSB278 O 81970270 O and O 82170327 O This O research O was O funded O by O the O Humanities O and O Social O Sciences O Research O of O the O Ministry O of O Education O of O China O 18YJCZH184 O the O National B-ORG Social I-ORG Science I-ORG Fund I-ORG of I-ORG China I-ORG 19CGL002 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Tianjin I-ORG 19JCQNJC14800 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M640232 O the B-ORG National I-ORG Science I-ORG Foundation I-ORG DMS-1737861 O DMS-1558127 O and O the O James O S. O McDonnell O Foundation O 21st O Century O Science O Initiative O in O Studying O Complex O Systems O Scholar O Award O UHC O Scholar O Award O 220020472 O This O paper O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 52174125 O and O 52004171 B-AWARD Fundamental B-ORG Research I-ORG Program I-ORG of I-ORG Shanxi I-ORG Province-Outstanding I-ORG Youth I-ORG Cultivation I-ORG Project I-ORG in I-ORG Shanxi I-ORG Province I-ORG 202103021222008 O Research B-ORG Project I-ORG supported I-ORG by I-ORG Shanxi-Zheda I-ORG Institute I-ORG of I-ORG Advanced I-ORG Materials I-ORG and I-ORG Chemical I-ORG Engineering I-ORG 2022SX-TD010 O Research B-ORG Project I-ORG Supported I-ORG by I-ORG Shanxi I-ORG Scholarship I-ORG Council I-ORG of I-ORG China I-ORG 2020-044 O Distinguished B-ORG Youth I-ORG Funds I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51925402 O Tencent B-ORG Foundation I-ORG or I-ORG XPLORER I-ORG PRIZE I-ORG Shanxi I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG Funds I-ORG 20201102004 O and O Open O Funds O of O Education B-ORG Ministry I-ORG Key I-ORG Laboratory I-ORG of I-ORG Coal I-ORG Mine I-ORG Safe I-ORG and I-ORG Efficient I-ORG Mining I-ORG JYBSYS20206 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 81671896 B-AWARD the O Military B-ORG Medical I-ORG Innovation I-ORG Project I-ORG grant O No. O 18CXZ032 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG grant O No. O 2019A1515012088 B-AWARD and O the O Guangdong B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG grant O No. O 2017A020215055 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O Million O Women O Study O is O funded O by O the O UK O Medical B-ORG Research I-ORG Council I-ORG grant O no. O MR/K02700X/1 B-AWARD and O by O Cancer B-ORG Research I-ORG UK I-ORG grant O no. O C570/A16491 B-AWARD BJC O acknowledges O support O from O the O BHF B-ORG Centre I-ORG of I-ORG Research I-ORG Excellence I-ORG Oxford I-ORG British O Heart O Foundation O grant O RE/13/1/30181 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Institutional O research O funding O was O provided O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. B-AWARD 81570195 O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O No. B-AWARD 7182128 O the O Peking B-ORG Union I-ORG Medical I-ORG College I-ORG New I-ORG Star I-ORG 2011 O to O LJ O the O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG Grant O No. B-AWARD 2016-12M-1-002 O and O The B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. B-AWARD 2016YFC0901503 O This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81961128023 B-AWARD and O 82261128001 B-AWARD National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFE0124700 B-AWARD International B-ORG Atomic I-ORG Energy I-ORG Agency I-ORG CRP O E43032 I-AWARD and O RAS6092 B-AWARD Shanghai B-ORG Municipal I-ORG Health I-ORG Commission I-ORG 2020CXJQ01 O GWV-10.1-XK07 B-AWARD and O in O part O by O the O Gates B-ORG Foundation I-ORG Healthy I-ORG Birth I-ORG Growth I-ORG I-ORG Development I-ORG knowledge I-ORG integration I-ORG HBGDki I-ORG project I-ORG No. O OPP1153191 B-AWARD This O work O was O supported O by O Delta B-ORG Stewardship I-ORG Council I-ORG grant O 1470 O awarded O to O N.A.F O A.E.T O and O R.E.C O the O University B-ORG of I-ORG California I-ORG Davis I-ORG Agricultural I-ORG Experiment I-ORG Station I-ORG grant O 2098-H O awarded O to O N.A.F O and O grant O 2252-H O awarded O to O A.E.T O and O the O Department B-ORG of I-ORG Water I-ORG Resources I-ORG grant O 4600010855 O awarded O to O N.A.F O This O study O was O supported O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81470978 B-AWARD 81279834 B-AWARD Major B-ORG Program I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG No. O 2015B020226005 B-AWARD Key B-ORG Project I-ORG of I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG No. O 2015A030311040 B-AWARD Leading B-ORG Scientific I-ORG Technical I-ORG and I-ORG Innovation I-ORG Talents I-ORG of I-ORG Guangdong I-ORG Special I-ORG Support I-ORG Program I-ORG No. O 510204006192 B-AWARD The O funding O organizations O did O not O have O any O role O in O the O study O design O collection O analysis O or O interpretation O of O data O in O writing O of O the O manuscript O or O in O the O decision O to O submit O the O article O for O publication O This O work O is O partly O supported O by O Department O of O Reproduction O and O Genetics O and O nephropathy O This O work O was O supported O by O Key B-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG No.BM2015020 O Nanjing B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Project I-ORG No.201503010 O Nanjing B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG No.2014020008 O foundation B-ORG of I-ORG Nanjing I-ORG General I-ORG Hospital I-ORG of I-ORG Nanjing I-ORG Military I-ORG Command I-ORG PLA I-ORG No.2015046 O foundation O of O Nanjing O General O Hospital O of O Nanjing O Military O Command O PLA O No.2014044 O This O study O was O funded O by O Central B-ORG Government I-ORG Guides I-ORG Local I-ORG Science I-ORG Development I-ORG Project I-ORG China I-ORG Grant O No. O YDZX20193700004393 B-AWARD Special O Project I-ORG for I-ORG Demonstration I-ORG and I-ORG Guidance I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Benefiting I-ORG the I-ORG people I-ORG of I-ORG Qingdao I-ORG China I-ORG Grant O No. O 21-1-4-ny-6nsh B-AWARD and O Modern B-ORG Agricultural I-ORG Industry I-ORG Technology I-ORG System I-ORG Project I-ORG Shandong I-ORG Province I-ORG China I-ORG Grant O No. O SDAIT-05-06 B-AWARD The O funders O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O grants O from O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0500800 O China B-ORG Agricultural I-ORG Research I-ORG System I-ORG CARS-42-17 O Sichuan B-ORG Veterinary I-ORG Medicine I-ORG and I-ORG Drug I-ORG Innovation I-ORG Group I-ORG of I-ORG China I-ORG Agricultural I-ORG Research I-ORG System I-ORG SCCXTD-2020-18 O and O Integration B-ORG and I-ORG Demonstration I-ORG of I-ORG Key I-ORG Technologies I-ORG for I-ORG Goose I-ORG Industrial I-ORG Chain I-ORG in I-ORG Sichuan I-ORG Province I-ORG 2018NZ0005 O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81573602 B-AWARD No. O 81673600 B-AWARD No. O 81673559 B-AWARD No. O 81503331 B-AWARD the O Opening B-ORG Project I-ORG of I-ORG Zhejiang I-ORG Provincial I-ORG First-rate I-ORG Subject I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG Zhejiang I-ORG Chinese I-ORG Medical I-ORG University I-ORG No. O Ya2017004 B-AWARD and O 2017005 B-AWARD the O Public B-ORG Welfare I-ORG Application I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. O 2017C33174 B-AWARD and O the O Traditional O Chinese O Medicine O Key O Scientific O Research O Fund O Project O of O Zhejiang O Province O No. O 2018ZY004 B-AWARD This O research O was O supported O by O Hebei B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Project I-ORG E2022209036 O Key B-ORG R I-ORG I-ORG D I-ORG project I-ORG in I-ORG Hebei I-ORG Province I-ORG 22323601D O and O National B-ORG College I-ORG Students’ I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Training I-ORG Program O 202210081029 B-AWARD This O research O was O funded O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2021YFB3802300 O the O Guangdong B-ORG Major I-ORG Project I-ORG of I-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG 2021B0301030001 O the O National B-ORG Key I-ORG Laboratory I-ORG of I-ORG Shock I-ORG Wave I-ORG and I-ORG Detonation I-ORG Physics I-ORG Grant O Nos O JCKYS2022212004 B-AWARD and O Sichuan B-ORG Province I-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG G226 O This O work O was O financially O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China O No. O 2018YFC0310800 B-AWARD the O China B-ORG Ocean I-ORG Mineral I-ORG Resources I-ORG R I-ORG I-ORG D I-ORG Association I-ORG COMRA I-ORG Special I-ORG Foundation I-ORG No. O DY135-E2-2-03 B-AWARD DY135-E2-2-06 B-AWARD and O DY135-E2-3-04 B-AWARD the O Senior B-ORG User I-ORG Project I-ORG of I-ORG RV I-ORG KEXUE I-ORG No. O KEXUE2018G25 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O No. O 31572229 B-AWARD and O 41606155 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O grants O from O the B-ORG Science I-ORG and I-ORG technology I-ORG project I-ORG in I-ORG Wuhu I-ORG NO.2013cxy04 O Anhui B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG to O Yao O Zhang O NO.1508085MH149 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO.81200632 O This O work O was O supported O by O the O Frontier O Science O and O Technology O Innovation O Project O in O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG under O Grant O No. O 2016QY11W2003 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG under O Grant O No. O 2018JJ3607 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O No. O 51575517 B-AWARD and O National O Technology O Foundation O Project O under O Grant O No. O 181GF22006 O This O research O was O funded O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2020YFE0202300 O the O Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG JCYJ20200109150650397 O and O JCYJ20190813104211014 B-AWARD the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG Cooperation I-ORG and I-ORG Innovation I-ORG Mission I-ORG CAAS-XTCX2016001 O and O the O Young B-ORG Elite I-ORG Scientists I-ORG Sponsorship I-ORG Program I-ORG by I-ORG CAST I-ORG YESS O 2020QNRC001 B-AWARD This O research O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31972157 O the O Lingnan B-ORG Modern I-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Guangdong I-ORG Laboratory I-ORG Independent I-ORG Scientific I-ORG Research I-ORG Project I-ORG NZ2021032 O the O Fund B-ORG of I-ORG Guangdong I-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Food I-ORG Quality I-ORG and I-ORG Safety I-ORG China I-ORG 2018KF001 O and O the O Guangdong B-ORG Province I-ORG Universities I-ORG and O Colleges O Pearl O River O Scholar O Funded O Scheme O 2017 O This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31670895 B-AWARD 71673254 B-AWARD The B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of O China—The O construction O and O promotion O of O the O demonstration O system O of O based O on O telemedicine/Mhealth O network O Grant O No. O 2017YFC0909900 B-AWARD Program B-ORG of I-ORG Science I-ORG I-ORG Technology I-ORG of I-ORG Henan I-ORG Province I-ORG Grant O No. O 201602037 B-AWARD Special O funds O from O central O government O for O the O guidance O of O local O science O and O technology O development O Construction O and O demonstration O of O telemedicine O big O data O application O system O for O precision O medicine O Special O funds O of O major O science O and O technology O project O in O Henan O province O 2016 O Construction O and O demonstration O application O of O medical O and O health O big O data O analysis O system O based O on O telemedicine O cloud O platform O Grant O No. O 151100310800 O Doctor O research O team O fund O from O the O first O affiliated O hospital O of O Zhengzhou O University O for O the O in-hospital O Interdisciplinary O Collaboration O Research O The O impact O of O air O pollution O exposure O levels O on O lung O cancer O and O its O potential O molecular O mechanism O based O on O satellite O remote O sense O big O data O Grant O No. O 2016-BSTDJJ-15 O This O work O is O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21504031 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20150135 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2015M570404 O the O Talent O Scientific O Research O Fund O of O LSHU O No. O 2016XJJ-010 O the O 2016 O General O Project O of O Education O Department O of O Liaoning O Province O No. O L2016003 O the O Doctoral O Research O Fund O of O Liaoning O Science O and O Technology O Department O No. O 20170520158 O and O the O Opening O Funds O of O Key O Laboratory O of O Synthetic O and O Biological O Colloids O Ministry O of O Education O Jiangnan O University O JDSJ2018-05 O This O work O was O supported O by O the B-ORG Key-Area I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2018B030331001 O the B-ORG Strategic I-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDB32030200 O and O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31830035 O This O study O was O supported O by O the O Clinical B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG of I-ORG Jinan I-ORG City I-ORG No:201805040 O Medicine B-ORG and I-ORG Health I-ORG Science I-ORG Technology I-ORG Development I-ORG of I-ORG Shandong I-ORG Province I-ORG No:2017WS191 O Cardiovascular B-ORG Multidisciplinary I-ORG Integrated I-ORG Research I-ORG Fund I-ORG No: O CIMF-Z-2016-23-1823 B-AWARD The O data O collection O and O analysis O were O supported O by O a O grant O from O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG grant O number O ZR201702210404 B-AWARD None O of O the O funders O were O involved O in O the O design O of O the O study O data O collection O analysis O interpretation O of O data O or O manuscript O preparation O This O research O is O supported O by O the O following O three O funds O 1) O The B-ORG Start-Up I-ORG Funding I-ORG for I-ORG New I-ORG Faculty I-ORG at I-ORG Peking I-ORG University I-ORG Shenzhen I-ORG Graduate I-ORG School I-ORG 1270110033 O 2) O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG 2021A1515110537 O and O 3) O NSFC B-ORG Study O on O comprehensive O evaluation O and O planning O response O strategy O of O rural O community O resilience O in O post-disaster O reconstruction O area O 51908475 O This O study O was O supported O by O the O Scientific B-ORG and I-ORG Technological I-ORG Cooperation I-ORG and I-ORG Exchange I-ORG program I-ORG of I-ORG the I-ORG Science I-ORG and I-ORG Technology I-ORG Agency I-ORG of I-ORG Shanxi I-ORG grant O number O 202104041101044 B-AWARD the O Scientific B-ORG and I-ORG Technological I-ORG Innovation I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG Institutions I-ORG in I-ORG Shanxi I-ORG Province I-ORG grant O number O 2022L499 B-AWARD and O the O Shanxi B-ORG Scholarship I-ORG Council I-ORG of I-ORG China I-ORG grant O number O 2022–022 B-AWARD This O research O was O partially O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 319763 B-AWARD the B-ORG Scientific I-ORG Research I-ORG Fund I-ORG of I-ORG Hunan I-ORG Provincial I-ORG Education I-ORG Department I-ORG 21A0614 O and O the B-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG Huaihua I-ORG China I-ORG 2021R3102 O We O thank O NSF B-ORG DEB O 948930 O of O the O USA O and O Biosilva B-ORG #5 O PICT B-ORG 2016-1421 O and O PICT O 2014-0662 O of O Argentina O This O work O was O supported O by O theEconomic O and I-ORG Social I-ORG Research I-ORG Council(ES/K0001892/1 O theNetherlands O Organisation I-ORG for I-ORG Scientific I-ORG Research(Veni O Award I-AWARD 451-11-002 O and O aMarie O Curie I-ORG Career I-ORG Integration I-ORG Grant(PCIG11-GA-2012-322256 O to O E.S.C O Funding O to O pay O the O Open O Access O publication O charges O for O this O article O was O provided O by O an O ESRC O grant O to O E.S.C O ES/K001892/1 O and O from O Bangor O University's O RCUK O Open O Access O Block O Grant O This O study O was O subsidized O by O tobacco O industry O Screening B-ORG of I-ORG new I-ORG high I-ORG quality I-ORG flue-cured I-ORG tobacco I-ORG varieties I-ORG in I-ORG Qingyang I-ORG 201862100020017 O Research B-ORG and I-ORG application I-ORG of I-ORG tobacco I-ORG and I-ORG water I-ORG fertilizer I-ORG integration I-ORG in I-ORG Qingyang I-ORG 201862100020016 O Development B-ORG and I-ORG application I-ORG of I-ORG rapid I-ORG detection I-ORG method I-ORG for I-ORG Tobacco I-ORG virus I-ORG SCYC201804 O and O Research B-ORG and I-ORG Application I-ORG of I-ORG Green I-ORG Prevention I-ORG and I-ORG Control I-ORG Technology I-ORG in I-ORG Tobacco I-ORG virus I-ORG in I-ORG Jiangxi I-ORG 201701002 O This O research O was O funded O by O the O Ligue B-ORG contre I-ORG le I-ORG Cancer-Septentrion I-ORG Comité O du I-AWARD Nord I-AWARD Comité I-AWARD du I-AWARD Pas-de-Calais O the O Association B-ORG Laurette I-ORG Fugain I-ORG ALF-2016/05 O the O Association B-ORG pour I-ORG la I-ORG Recherche I-ORG sur I-ORG le I-ORG Cancer I-ORG ARC-SFI20111203669 O the O FEDER-Région O Nord-Pas-de-Calais O the O SIRIC O ONCOLille O Grant O INCa-DGOS-Inserm I-AWARD 6041 O and O the O Institut O pour O la O Recherche O sur O le O Cancer O de O Lille O IRCL B-AWARD This O work O was O supported O by O the O National B-ORG 973 I-ORG Program I-ORG 2015CB553904 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81490753 O 81830086 I-AWARD and I-AWARD 81672455 O the O Beijing B-ORG Nova I-ORG Program I-ORG xx2018040 O and O the O CAMS B-ORG Initiative I-ORG for I-ORG Innovative I-ORG Medicine I-ORG 2017-I2M-3-004 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O in O part O by O the O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG LY16H160004 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG 17ZR1422500 O and O 19ZR1456300 B-AWARD Shanghai B-ORG Municipal I-ORG Population I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG 201540304 O and O Interdisciplinary B-ORG Program I-ORG of I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG YG2016MS26 O This O work O was O supported O by O the O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo I-ORG FAPESP I-ORG grants O to O GMC O 2013/04516-1 O and O ASH O 2011/14080-0 O by O the O Conselho B-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG grant O to O GMC O 140808/2016-7 O by O the O Instituto B-ORG Venezolano I-ORG de I-ORG Investigaciones I-ORG Científicas I-ORG IVIC I-ORG grant O to O AR O 1096 O and O by O the O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG de I-ORG Minas I-ORG Gerais I-ORG FAPEMIG I-ORG grant O to O DR O APQ-02490-12 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O grants O from O the O Joint O Program O on O the O Science B-ORG and I-ORG Technology I-ORG Collaboration I-ORG of I-ORG Southwest I-ORG Medical I-ORG University I-ORG and I-ORG the I-ORG Government I-ORG of I-ORG Luzhou I-ORG City I-ORG 2018LZXNYD-PT04 O the O Science B-ORG Technology I-ORG Support I-ORG Plan I-ORG Projects I-ORG of I-ORG Luzhou I-ORG 2015LZCYD-S02 O and O the O Program O of O Southwest O Medical O University O 2017-ZRQN-005 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Okinawa O Prefectural O Government O Japan B-ORG Agency I-ORG for I-ORG Medical I-ORG Research I-ORG and I-ORG Development O Grant O Number O JP18gm1010005 B-AWARD Japan B-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science O Grant O Number O 16K09933,18K08431 B-AWARD Ministry B-ORG of I-ORG Internal I-ORG Affairs I-ORG and I-ORG Communications O Grant O Number O 172107106 O The O work O was O undertaken O with O the O support O of O The O Centre B-ORG for I-ORG the I-ORG Development I-ORG and I-ORG Evaluation I-ORG of I-ORG Complex I-ORG Interventions I-ORG for I-ORG Public I-ORG Health I-ORG Improvement I-ORG DECIPHer O a O UKCRC O Public O Health O Research O Centre O of O Excellence O Joint O funding O MR/KO232331/1 O from O the O British O Heart O Foundation O Cancer O Research O UK, O Economic O and O Social O Research O Council O Medical O Research O Council O the O Welsh O Government O and O the O Wellcome O Trust O under O the O auspices O of O the O UK O Clinical O Research O Collaboration O is O gratefully O acknowledged O CW O is O funded O by O a O Cancer B-ORG Research I-ORG UK I-ORG Population I-ORG Research I-ORG Postdoctoral I-ORG Fellowship I-ORG C60153/A23895 O The O UK B-ORG Medical I-ORG Research I-ORG Council I-ORG and I-ORG Wellcome I-ORG Grant O ref O 102215/2/13/2 B-AWARD and O the O University O of O Bristol O provide O core O support O for O ALSPAC O These O funding O bodies O had O no O role O in O the O design O analysis O or O interpretation O of O the O study O or O in O writing O the O manuscript O This O publication O is O the O work O of O the O authors O and O they O will O serve O as O guarantors O for O the O contents O of O this O paper O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51603027 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Chongqing I-ORG No. O cstc2016jcyjA0519 B-AWARD and O cstc2018jcyjAX0565 B-AWARD Scientific B-ORG and I-ORG Technological I-ORG Research I-ORG Program I-ORG of I-ORG Chongqing I-ORG Municipal I-ORG Education I-ORG Commission I-ORG Grant O No. O KJ1600920 B-AWARD SL O received O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG 2018J01700 O and O the B-ORG Research I-ORG Fund I-ORG of I-ORG the I-ORG Education I-ORG Department I-ORG of I-ORG Fujian I-ORG Province I-ORG JA12098 O ZL O received O the B-ORG Major I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Fujian I-ORG Province I-ORG 2015NZ0002-1 O and O the B-ORG Program I-ORG for I-ORG High-level I-ORG University I-ORG Construction I-ORG of I-ORG the I-ORG Fujian I-ORG Agriculture I-ORG and I-ORG Forestry I-ORG University I-ORG 612014028 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O MAM O acknowledges O support O from O the O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG FDN-143288 O the O BC O Cancer O Foundation O Genome B-ORG Canada I-ORG 212SEQ O and O Genome B-ORG British I-ORG Columbia I-ORG 202SEQ O We O are O grateful O for O support O from O the O Canada O Foundation O for O Innovation O and O the O National B-ORG Cancer I-ORG Institute O National O Institutes O of O Health O under O Contract O No. O HHSN261200800001E B-AWARD The O content O of O this O publication O does O not O necessarily O reflect O the O views O of O policies O of O the O Department O of O Health O and O Human O Services O nor O does O mention O of O trade O names O commercial O products O or O organizations O imply O endorsement O by O the O U.S O Government O This O study O was O supported O by O the O Natural B-ORG Sciences I-ORG Foundation I-ORG of I-ORG China I-ORG Science I-ORG 81872959 O 81373920 B-AWARD 30801522 B-AWARD the O Yong B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Team I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2019CXTD0055 O and O the O China B-ORG scholarship I-ORG foundation I-ORG 201708510027 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O Chinese B-ORG Foundation I-ORG for I-ORG Hepatitis I-ORG Prevention I-ORG and I-ORG Control-TianQing I-ORG Liver I-ORG Disease I-ORG Research I-ORG Fund I-ORG No. O TQGB20150231 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG of I-ORG China I-ORG No. O H2015106081 B-AWARD and O the O Hebei B-ORG Medical I-ORG Research I-ORG Foundation I-ORG No. O 20150893 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O grants O WQ20123700079 B-AWARD from O One B-ORG Thousand I-ORG Talents I-ORG Plan I-ORG of I-ORG China I-ORG www.1000plan.org O tshw20120743 B-AWARD from O Taishan B-ORG Scholar I-ORG Plan I-ORG of I-ORG Shandong I-ORG Province O 2014QN021 B-AWARD from O Youth B-ORG Foundation I-ORG of I-ORG Shandong I-ORG Academy I-ORG of I-ORG Sciences I-ORG and O BS2014SW030 B-AWARD from O Science B-ORG Foundation I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG of I-ORG Shandong I-ORG Province I-ORG http://www.sdnsf.gov.cn O This O work O was O supported O by O grants O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31201657 B-AWARD the B-ORG major I-ORG program I-ORG of I-ORG Yangling I-ORG Agricultural I-ORG Hi-tech I-ORG Industry I-ORG Demo I-ORG Zone I-ORG synergy I-ORG innovation I-ORG for I-ORG cooperation I-ORG in I-ORG production I-ORG study I-ORG and I-ORG research I-ORG 2016CXY-11 O and O the B-ORG project I-ORG for I-ORG Agriculture I-ORG Sci-Tech I-ORG demonstration I-ORG and I-ORG extension I-ORG of I-ORG Yangling I-ORG Agricultural I-ORG Hi-tech I-ORG Industry I-ORG Demo I-ORG Zone I-ORG TS-2016-18 O The O study O was O performed O in O State O Key O Laboratory O of O Crop O Stress O Biology O for O Arid O Areas O Northwest O A&F O University O and O Key O Laboratory O of O Protected O Horticulture O Engineering O in O Northwest O China O Ministry O of O Agriculture O the O People’s O Republic O of O China O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No O 81700553 B-AWARD the O Stem B-ORG Cell I-ORG and I-ORG Translational I-ORG Research I-ORG the I-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFA0101001 B-AWARD and O the O Postdoctoral B-ORG Research I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 2017M183789 B-AWARD This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81702577 O and O Natural B-ORG Science I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG Shaanxi I-ORG No. O 2018JQ8035 B-AWARD and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O XZY012019105 B-AWARD This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31872407 O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG Central I-ORG Nonprofit I-ORG Research I-ORG Institutes I-ORG 1610332018008 O the B-ORG Chinese I-ORG National I-ORG Key I-ORG Basic I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2014CB138804 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O the O manuscript O preparation O This O research O was O supported O by O the O Bio&Medical O Technology O Development O Program O of O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O funded O by O the O Ministry O of O Science O ICT O O Future O Planning O NRF-2014M3A9D7034335 O and O by O the O research O program O of O Korea B-ORG Institute I-ORG of I-ORG Oriental I-ORG Medicine I-ORG No. O K16091 B-AWARD This O study O was O provided O with O bioresources O from O National B-ORG Biobank I-ORG of I-ORG Korea O the O Centers O for O Disease O Control O and O Prevention O Republic O of O Korea O 4845-301 O 4851-302 I-AWARD and I-AWARD 307 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O project O was O supported O by O the O National B-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG 81141019 O to O CW; O Hainan B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Key I-ORG Program I-ORG ZDXM2014062 O to O CW; O Hainan B-ORG Province I-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG 813227 O to O CW; O Hainan B-ORG Province I-ORG Medical I-ORG Scientific I-ORG Research I-ORG Subject I-ORG Qiong2012PT-73 O to O CW; O and O Binzhou B-ORG Medical I-ORG College I-ORG Scientific I-ORG Plan I-ORG and I-ORG Research I-ORG Foundation I-ORG BY2015KJ17 O to O XL. O The O research O is O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0307701 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41427803 O and O Open B-ORG Fund I-ORG of I-ORG Qingdao I-ORG National I-ORG Laboratory I-ORG for I-ORG Marine I-ORG Science I-ORG and I-ORG Technology I-ORG QNLM2016ORP0414 O The O Geneva O team O was O supported O by O grants O from O the O Swiss B-ORG National I-ORG Science I-ORG Foundation I-ORG 310000-141162 O the O Juvenile B-ORG Diabetes I-ORG Research I-ORG Foundation I-ORG 40-2011-11 O and O the O European B-ORG Union I-ORG IMIDIA O C2008-T7 O The O Leuven O team O is O supported O by O a O grant O from O the O KUL B-ORG GOA O 2014/010 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O with O the O funding O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 31772861 B-AWARD and O 31372546 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG of O China O Grant O No. O 2018Y0078 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Major/Special I-ORG Project I-ORG of I-ORG Fujian I-ORG Province I-ORG No. O 2016NZ0001-3 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 31400602 O the O Henan B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Breakthrough I-ORG Project I-ORG 172102310054 O and O the O Applied B-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Fund I-ORG of I-ORG Luoyang I-ORG Normal I-ORG University I-ORG 2015-YYJJ-003 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O work O was O supported O by O The B-ORG National I-ORG Key I-ORG Basic I-ORG Research I-ORG Development I-ORG Plan I-ORG 973 O Plan I-AWARD 2014CB542006 O International B-ORG Science I-ORG and I-ORG Technology I-ORG Corporation I-ORG and I-ORG Exchange I-ORG Project I-ORG 2015DFA31090 O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG CIFMS I-ORG 2016-I2M-1-001 O This O study O was O funded O by O the O Nature B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 81871967 O Social B-ORG Development I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG of I-ORG China I-ORG No.BE2018604 O Jiangsu B-ORG Provincial I-ORG Medical I-ORG Talent I-ORG and I-ORG the I-ORG Nanjing I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG No.201803028 O The O funding O bodies O supported O the O H&E O R&F O SMA O staining O experiments O and O article O polishing O The O funding O bodies O had O no O role O in O the O design O of O the O study O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O sponsored O by O the O Humanities O and O Social O Sciences O Project O of O the O Ministry B-ORG of I-ORG Education I-ORG of I-ORG China I-ORG No. O 17YJA190018 B-AWARD the O Philosophy B-ORG and I-ORG Social I-ORG Science I-ORG Project I-ORG of I-ORG Henan I-ORG Province I-ORG No. O 2017BJY004 B-AWARD Henan B-ORG University I-ORG Philosophy I-ORG and I-ORG Social I-ORG Science I-ORG Innovation I-ORG Team I-ORG No. O 2019CXTD009 B-AWARD and O Program B-ORG for I-ORG Science I-ORG I-ORG Technology I-ORG Innovation I-ORG Talents I-ORG in I-ORG Universities I-ORG of I-ORG Henan I-ORG Province I-ORG Humanities O and O social O sciences O No. O 2021-CX-032 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31400202 O to O CX O and O 31900197 B-AWARD to O YW O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jilin I-ORG Province I-ORG 20200201112JC O to O YW O and O Young B-ORG Science I-ORG and I-ORG Technology I-ORG Talent I-ORG Foundation I-ORG of I-ORG Jilin I-ORG Province I-ORG QT202018 O to O YW O The O study O was O funded O by O the O National B-ORG Natural I-ORG Scientific I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31670982 B-AWARD Clinical B-ORG Medicine I-ORG Plus I-ORG X-Young I-ORG Scholars I-ORG Project I-ORG of I-ORG Peking I-ORG University I-ORG PKU2018LCXQ009 O and O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China(2018YFF0301100)in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O supported O by O the O Swiss B-ORG National I-ORG Science I-ORG Foundation I-ORG Grant O P2BEP3_168670 B-AWARD to O R.S O by O the O Rosetrees B-ORG Trust I-ORG Grant O A1699 B-AWARD to O A.D.H O and O M.A.L-R O by O the O Medical B-ORG Research I-ORG Council I-ORG Grant O MR/R023883/1 B-AWARD to O M.A.L-R O and O by O the O European B-ORG Research I-ORG Council I-ORG Grant O GAP O 670428 B-AWARD to O M.A.L-R O This O work O was O financial O supported O by O the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2012AA10A411 B-AWARD The B-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG and I-ORG Comprehensive I-ORG Strategy I-ORG Cooperation I-ORG Projects I-ORG in I-ORG Guangdong I-ORG Province I-ORG Grant O No. O 2011A090100040 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31000189 B-AWARD This O work O is O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81601677 O Medical B-ORG Research I-ORG Funding I-ORG of I-ORG PLA I-ORG of I-ORG China I-ORG AWS14C003 O and O 17QNP005 B-AWARD and O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG for I-ORG Academicians I-ORG of I-ORG Chongqing I-ORG cstc2017jcyj-yszxX0007 O This O work O was O supported O by O the O CAMS B-ORG Initiative I-ORG for I-ORG Innovative I-ORG Medicine I-ORG grant O number O 2017-I2M-3-001 B-AWARD received O by O C.Li O the O Capital B-ORG Medical I-ORG Research I-ORG and I-ORG Development I-ORG Fund I-ORG grant O number O 2016-4-40112 B-AWARD received O by O C.Li O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O number O 2016YFC0901500 B-AWARD received O by O C.Li O the O State B-ORG Key I-ORG Project I-ORG Clinical I-ORG Cohort I-ORG Study I-ORG of I-ORG Rare I-ORG Diseases I-ORG Rare I-ORG Lung I-ORG Disease I-ORG Research I-ORG Group I-ORG in I-ORG China I-ORG 2016YFC0901502 O received O by O X.Tian O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O presented O was O partially O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2022YFB2902600 B-AWARD the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 62171234 B-AWARD and O No. O U21A20450 B-AWARD and O the O Jiangsu B-ORG Province I-ORG Basic I-ORG Research I-ORG Project I-ORG No. O BK20192002 B-AWARD This O project O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grants O 81400862 B-AWARD 81401606 B-AWARD and O 81701880 B-AWARD the O Key B-ORG Project I-ORG in I-ORG the I-ORG Science I-ORG I-ORG Technology I-ORG Program I-ORG of I-ORG Sichuan I-ORG Province I-ORG Grant O No: O 2019YFS0322 B-AWARD and O the O Science B-ORG Foundation I-ORG for I-ORG The I-ORG Excellent I-ORG Youth I-ORG Scholars I-ORG of I-ORG Sichuan I-ORG University I-ORG Grants O 2015SU04A15 B-AWARD The O work O was O supported O by O the O Key B-ORG Project I-ORG and I-ORG Special I-ORG Foundation I-ORG of I-ORG Research I-ORG Development I-ORG and I-ORG Promotion I-ORG in I-ORG Henan I-ORG Province I-ORG China I-ORG 222102110070 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31800165 O 32000147 B-AWARD Research B-ORG start-up I-ORG fund I-ORG to I-ORG young I-ORG talents I-ORG of I-ORG Henan I-ORG Agricultural I-ORG University I-ORG 30500686 O and O Program B-ORG for I-ORG Innovative I-ORG Research I-ORG Team I-ORG in I-ORG Science I-ORG and I-ORG Technology I-ORG in I-ORG University I-ORG of I-ORG Henan I-ORG Province I-ORG 221RTSTHN0230 O This O work O was O financially O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31672455 B-AWARD the B-ORG Outstanding I-ORG Young I-ORG Talent I-ORG Fund I-ORG from I-ORG Key I-ORG Projects I-ORG in I-ORG Hubei I-ORG Province I-ORG Natural I-ORG Science I-ORG Foundation I-ORG NSF O 2018CFA077 O and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG CZT18002 O CZT18003 O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 82070674 B-AWARD the O Sichuan B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG Project I-ORG no. O 2019YFG0036 B-AWARD the O Sichuan B-ORG Natural I-ORG Science I-ORG Foundation I-ORG no. O 2022NSFSC0805 B-AWARD and O the O 1.3.5 B-ORG Project I-ORG for I-ORG Disciplines I-ORG of I-ORG Excellence I-ORG West I-ORG China I-ORG Hospital I-ORG Sichuan I-ORG University I-ORG no. O ZY2017308 B-AWARD This O work O was O supported O by O grants O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81672896 B-AWARD NO. O 81272532 B-AWARD the B-ORG Jiangsu I-ORG Province I-ORG Clinical I-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG Clinical O Research O Center O BL2012008 B-AWARD and O the B-ORG Priority I-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG JX10231801 O This O work O was O supported O by O the B-ORG National I-ORG Science I-ORG Grant I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG grant O number O 81425001/H0104 B-AWARD the B-ORG National I-ORG Key I-ORG Technology I-ORG Support I-ORG Program I-ORG from I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG grant O number O 2015BAI12B11 B-AWARD and O the B-ORG Beijing I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG grant O number O D151100002115004 B-AWARD This O research O was O funded O by O the O Hong B-ORG Kong I-ORG Baptist I-ORG University I-ORG FRG2/17-18/003 O the O Health B-ORG and I-ORG Medical I-ORG Research I-ORG Fund I-ORG HMRF/14150561 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 201575121and O 21775131 B-AWARD China O the O Hong O Kong O Baptist O University O Century O Club O Sponsorship O Scheme O 2018 O China O the O Interdisciplinary O Research O Matching O Scheme O RC-IRMS/16-17/03 O China O the O Interdisciplinary O Research O Clusters O Matching O Scheme O RC-IRCs/17-18/03 O China O the O Collaborative O Research O Fund O C5026-16G O China O the O SKLEBA O and O HKBU O Strategic O Development O Fund O SKLP_1718_P04 O China O the O Science O and O Technology O Development O Fund O the O Macau O SAR O File O no. O 0072/2018/A2 O and O SKL-QRCM-2017-2019 O and O the O University B-ORG of I-ORG Macau I-ORG MYRG2018-00187-ICMS O China O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 31600394 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Foundation I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Forestry I-ORG grant O number O CAFYBB2007008 B-AWARD the O State B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O number O 2016YFC0500806 B-AWARD the O Funding B-ORG of I-ORG Basic I-ORG Scientific I-ORG Research I-ORG Operations I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Forestry I-ORG grant O number O CAFYBB2020MB007 B-AWARD and O the O Central B-ORG and I-ORG local I-ORG science I-ORG and I-ORG technology I-ORG development I-ORG fund I-ORG project I-ORG Grant O Nos O 2022ZY0177 B-AWARD This O research O was O supported O by O the O Shenzhen B-ORG Municipal I-ORG Government I-ORG of I-ORG China I-ORG Peacock I-ORG Plan I-ORG No. O KQTD2015033017150531 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2018YFD0900301-05 B-AWARD and O the O Qingdao B-ORG Applied I-ORG Basic I-ORG Research I-ORG Projects I-ORG Grant O No. O 19-6-2-33-cg B-AWARD This O research O was O supported O by O Taizhou B-ORG university I-ORG Foundation I-ORG 2017PY034 O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG LQ19C030001 O the B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2016F50024 O and O the B-ORG Major I-ORG scientific I-ORG and I-ORG technological I-ORG projects I-ORG for I-ORG breeding I-ORG new I-ORG varieties I-ORG of I-ORG Agriculture I-ORG of I-ORG Zhejiang I-ORG Province I-ORG China I-ORG 2016C02056-12 O This O research O was O funded O by O the O SERB B-ORG EMR/2016/007845 O DBT B-ORG BT/PR14240/MED/29/985/2015 O and O MoE-IISc-STARS B-ORG STARS/APR2019/BS/584/FS O India O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61501228 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG No. O BK20140825 O Aeronautical B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.20152052029 O No.20182052012 O Basic B-ORG Research I-ORG No. O NS2015040 O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH)-funded I-ORG Research I-ORG Resource I-ORG for I-ORG Biomedical I-ORG Glycomics I-ORG P41GM10349010 O NIH–funded B-ORG Orbitrap I-ORG Fusion I-ORG Tribrid I-ORG Mass I-ORG Spectrometer I-ORG 1S10OD018530 O to O P.A O Bill B-ORG and I-ORG Melinda I-ORG Gates I-ORG Foundation I-ORG OPP1173478 O “Microbiome O and O Metabolomic O Analysis O of O Selected O PROVIDE O Samples” O This O work O was O supported O by O Key B-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG Hainan I-ORG Province I-ORG grant O number O ZDYF2016128 B-AWARD ZDYF2017092 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 21102184 B-AWARD 81573508 B-AWARD 81773640 B-AWARD 81874327 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O number O 2016YFC1306900 B-AWARD 2016YFC0905002 B-AWARD and O the O Strategy-Oriented B-ORG Special I-ORG Project I-ORG of I-ORG Central I-ORG South I-ORG University I-ORG in I-ORG China I-ORG grant O number O ZLXD2017003 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the B-ORG Coordenação I-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior—Brasil I-ORG CAPES O for O the O financial O support O for O this O study O finance O Code O 001 B-AWARD Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo I-ORG FAPESP O Grants O 2019/06170-1 B-AWARD and O 2013/07296-2 B-AWARD CEPID O and O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPQ O Grant O No. O 312530/2018-8 B-AWARD Research O reported O in O this O publication O was O supported O by O aGates O Grand I-ORG Challenges I-ORG Explorationsgrant O OPP1172004 O theEunice O Kennedy I-ORG Shriver I-ORG National I-ORG Institute I-ORG of I-ORG Child I-ORG Health I-ORG I-ORG Human I-ORG Development I-ORG of I-ORG the I-ORG National I-ORG Institutes I-ORG of I-ORG Health(F31HD097841 O C.R O and O F32HD100202 B-AWARD E.M.L O and O theNational O Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases I-ORG of I-ORG the I-ORG National I-ORG Institutes I-ORG of I-ORG Health(K01AI11628 O A.L.D O The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O National O Institutes O of O Health O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 81672376 B-AWARD the B-ORG Youth I-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG Fujian I-ORG Provincial I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG grant O nos O 2017-1-85 B-AWARD 2017-2-60 B-AWARD and O 2018-1-93 B-AWARD the B-ORG Fuzhou I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG grant O no. O 2017-S-wt2 B-AWARD and O the B-ORG Startup I-ORG Fund I-ORG for I-ORG scientific I-ORG research I-ORG Fujian I-ORG Medical I-ORG University I-ORG grant O nos O 2016QH080 B-AWARD 2016QH081 B-AWARD and O 2018QH1198 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31672554 O Key B-ORG scientific I-ORG and I-ORG technological I-ORG project I-ORG of I-ORG Jilin I-ORG Province I-ORG 20140204076NY O Funding B-ORG of I-ORG world I-ORG bank I-ORG financed I-ORG project I-ORG of I-ORG Jilin I-ORG Province I-ORG 2011-Y20 O and O the B-ORG program I-ORG Supported I-ORG by I-ORG Jilin I-ORG University I-ORG for I-ORG the I-ORG Excellent I-ORG Youth I-ORG Scholars I-ORG 419080500593 O This O work O was O funded O by O NIH/NIA B-ORG P30-AG-028716 B-AWARD VBK O China B-ORG Health I-ORG Ministry I-ORG Program I-ORG 201302007 O and O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 81702185 O This O work O was O supported O by O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG No. O 2013ZX10004-101 I-AWARD and O No. B-AWARD 2015ZX09J15105-001-001 O the O Science B-ORG and I-ORG Technology I-ORG Major I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2012A080203005 O and O the O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Tianjin I-ORG No. O 15PTGCSY00150 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund O CAFS O 2016RC-LX05 O the O Earmarked B-ORG Fund I-ORG for I-ORG Modern I-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG CARS-48 O the O Pearl B-ORG River I-ORG S&T I-ORG Nova I-ORG Program I-ORG of I-ORG Guangzhou I-ORG 2014J2200018 O and O the O Guangdong B-ORG Special I-ORG Support I-ORG Program I-ORG 00-201620641 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 81573023 B-AWARD no. O 31601075 B-AWARD no. O 31571363 B-AWARD and O no. O 31100912 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG no. O 2016YFC1303200 B-AWARD and O Shanghai B-ORG Municipal I-ORG Health I-ORG Commission I-ORG no. O 2019CXJQ03 B-AWARD This O study O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81602103 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20160114 O Distinguished B-ORG Young I-ORG Scholar I-ORG Project I-ORG of I-ORG Medical I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Foundation I-ORG of I-ORG Nanjing I-ORG Department I-ORG of I-ORG Health I-ORG JQX17005 O Key B-ORG Project I-ORG of I-ORG Medical I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Foundation I-ORG of I-ORG Nanjing I-ORG Department I-ORG of I-ORG Health I-ORG YKK16114 O Medical B-ORG Research I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Provincial I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Q2017007 O and O Wu B-ORG Jieping I-ORG Medical I-ORG Foundation I-ORG 320.2710.1817 O This O research O was O funded O by O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Republic I-ORG of I-ORG Korea I-ORG NRF-2022R1A2C1003638 O the O Basic B-ORG Research I-ORG Lab I-ORG Program I-ORG 2022R1A4A1025557 O through O the O NRF O of O Republic O of O Korea O funded O by O the O Ministry O of O Science O and O ICT O the O Republic B-ORG of I-ORG Korea I-ORG Institute I-ORG of I-ORG Planning I-ORG and I-ORG Evaluation I-ORG for I-ORG Technology I-ORG in I-ORG Food I-ORG Agriculture I-ORG Forestry I-ORG and I-ORG Fisheries I-ORG IPET O through O Agriculture O Food O and O Rural O Affairs O Convergence O Technologies O Program O for O Educating O Creative O Global O Leader O funded O by O Ministry O of O Agriculture O Food O and O Rural O Affairs O MAFRA O 320005-4 B-AWARD the O National B-ORG IT I-ORG Industry I-ORG Promotion I-ORG Agency I-ORG NIPA I-ORG of I-ORG Republic I-ORG of I-ORG Korea I-ORG grant O funded O by O the O Republic O of O Korea O government O MSIT)(S2005-22-1031 O and O the O Global B-ORG Research I-ORG and I-ORG Development I-ORG Centre I-ORG GRDC O Program O through O the O NRF O of O Republic O of O Korea O funded O by O the O Ministry O of O Science O and O ICT O 2017K1A4A3014959 O This O research O was O funded O by O the O Zhejiang B-ORG Natural I-ORG Science I-ORG Foundation O grant O number O LY20C170002 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation O grant O number O 31772677 O The O APC O was O funded O by O the O Zhejiang B-ORG Provincial I-ORG Public I-ORG Welfare I-ORG Technology I-ORG Application I-ORG Research I-ORG Project O grant O number O LGN21C010001 O This O study O was O supported O by O The O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grants O 82000073 B-AWARD The O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Nankai I-ORG University I-ORG Grant O 735-63221434 B-AWARD and O The O Foundation B-ORG of I-ORG Organ I-ORG Fibrosis I-ORG Druggability I-ORG Joint I-ORG Research I-ORG Centre I-ORG of I-ORG Nankai I-ORG and I-ORG Guokaixingcheng I-ORG Grant O 735-F1040051 B-AWARD This O work O was O supported O by O grants O from O the B-ORG State I-ORG Key I-ORG Basic I-ORG Research I-ORG and O Development B-ORG Program I-ORG of I-ORG China I-ORG 2014CB147301 O 2016YFD0101003 B-AWARD and O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2014CQ055 O This O work O was O supported O by O the O Educational B-ORG Commission I-ORG of I-ORG Guangdong I-ORG Province O China O 2021ZDZX2051 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O China O 2023A1515012637 O Li B-ORG Ka I-ORG Shing I-ORG Foundation I-ORG Cross-Disciplinary I-ORG Research I-ORG Grant O 2020LKSFG02E O The O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFA0900501 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31700085 O and O the O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG President’s O International O Fellowship O Initiative O CAS O PIFI O 2018VBA0013 O to O VM O and O 2018PB0036 B-AWARD to O TC O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81200770 B-AWARD and O 81571213 B-AWARD the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG grant O number O 2017YFA0104304 B-AWARD 13th B-ORG Jiangsu I-ORG Province I-ORG Six I-ORG talent I-ORG peaks I-ORG project I-ORG C O type O the B-ORG Nanjing I-ORG Medical I-ORG Science I-ORG and I-ORG technique I-ORG Development I-ORG Foundation I-ORG grant O number O QRX17006 B-AWARD The O authors O are O grateful O to O the O Foundation B-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG FCT O Portugal O for O financial O support O through O national O funds O FCT/MCTES O PIDDAC O to O CIMO O UIDB/00690/2020 O and O UIDP/00690/2020 B-AWARD and O SusTEC O LA/P/0007/2021 O National O funding O by O FCT B-ORG P.I O through O the O scientific O employment O program-contract O for O M.I.D O CEECINST O J. O Pinela O CEECIND/01011/2018 O R.C.C O CEECINST O and O L.B O CEECINST O contracts O and O B.R.A B-ORG PhD I-ORG grant O SFRH/BD/136370/2018 O and O COVID/BD/152908/2022 B-AWARD To O the O MICINN B-ORG for O the O Juan O de O la O Cierva O Formación O contract O for O T.C.S.P.P O FJC20120-045405-I O R.C.G.C O is O a O research O grant O recipient O of O Cesumar O Institute O of O Science O Technology O and O Innovation O ICETI O This O work O was O supported O by O the O Youth B-ORG Fund I-ORG of I-ORG the I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG of I-ORG China I-ORG grant O number I-AWARD BK20160216 O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Normal I-ORG University I-ORG grant O number I-AWARD 15XLR028 O the B-ORG Project I-ORG for I-ORG Extramural I-ORG Scientists I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Agro-biotechnology I-ORG grant B-AWARD number I-AWARD 2017SKLAB7-3 O and O the B-ORG Youth I-ORG Fund I-ORG of I-ORG the I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Beijing I-ORG grant O number I-AWARD 7194290 O This O research O was O supported O by O the O Basic O Science O Research O Program O through O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O funded O by O the O Ministry O of O Education O Science O and O Technology O 2015R1A1A1A05001599 O and O by O the O Ministry O of O Science O and O ICT O Republic O of O Korea O 2018R1C1B5045006 O The O authors O also O wish O to O acknowledge O the O financial O support O of O the O Korean B-ORG Society I-ORG of I-ORG Nephrology I-ORG Chong O Kun I-AWARD Dang I-AWARD 2016 O and O Soonchunhyang B-ORG University I-ORG Research B-AWARD Fund I-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32070630 O and O 32100477 B-AWARD the O National B-ORG Key I-ORG R&D I-ORG Project I-ORG of I-ORG China I-ORG 2018YFA0800102 O the O National O Natural O Science O Foundation O of O China O 82100171 O the O Ningbo B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2018A610326 O the O Medical B-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Provincial I-ORG Health I-ORG Commission I-ORG 2019KY574 O and O the O Zhejiang B-ORG Innovation I-ORG Team I-ORG Grant I-ORG 2020R01006 O The O authors O acknowledge O the O support O from O the O Farr O Institute O of O Health O Informatics O Research O and O Dundee O University O Medical O School O This O work O was O supported O by O the O Medical B-ORG Research I-ORG Council I-ORG MRC O grant O number O MR/M501633/1 B-AWARD PI: O Andrew O Morris O and O the O Wellcome B-ORG Trust I-ORG grant O number O WT086113 B-AWARD through O the O Scottish O Health O Informatics O Programme O SHIP O PI: O Andrew O Morris O SHIP O is O a O collaboration O between O the O Universities O of O Aberdeen O Dundee O Edinburgh O Glasgow O and O St O Andrews O and O the O Information O Services O Division O of O NHS O Scotland O This O project O has O also O received O funding O from O the O European B-ORG Union's I-ORG Horizon I-ORG 2020 I-ORG research I-ORG and I-ORG innovation I-ORG programme I-ORG under O grant O agreement O No O 633 B-AWARD 983 I-AWARD PI: O Maria-Christina O Zennaro O This O work O was O supported O by O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O 81402564 B-AWARD to O Yuqing O Yao O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O 81773375 B-AWARD to O Yuqing O Yao O and O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China O grant O 2015AA020904 B-AWARD to O Yuqing O Yao O This O work O was O supported O by O theCritical O Path I-ORG Initiative I-ORG of I-ORG the I-ORG U.S I-ORG Food I-ORG and I-ORG Drug I-ORG Administration(contract O U18 B-AWARD FD004034 O andthe O Bill I-ORG and I-ORG Melinda I-ORG Gates I-ORG Foundation(OOP10396210 O CCY O acknowledges O support O from O theNational O Science I-ORG Foundation I-ORG Graduate I-ORG Research I-ORG Fellowship I-ORG Program(Grant O Number O 1256065 B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 21772233 B-AWARD 21977117 B-AWARD 81730100 B-AWARD 21807104 B-AWARD and O 81922067 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O BK20190306 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 2632020TD037 B-AWARD and O 2181900125 B-AWARD and O the O Postgraduate B-ORG Research I-ORG I-ORG Practice I-ORG Innovation I-ORG Programme I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O KYCX18_0790 B-AWARD This O work O was O supported O by O the O European B-ORG Union’s I-ORG Seventh I-ORG Framework I-ORG Programme I-ORG EU I-ORG FP7 I-ORG project O “ADITEC” O HEALTH-F4-2011-280873 O and O EU B-ORG Horizon I-ORG 2020 I-ORG project O “TBVAC O 2020” O grant O 643381 O to O SHEK O In O addition O the O work O was O supported O in O parts O by O a O Reinhard O Koselleck-Grant O of O the O Deutsche B-ORG Forschungsgemeinschaft I-ORG ME B-AWARD 2764/1-1 I-AWARD to O FM. O The O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 30572162 B-AWARD the O Liaoning B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG No. O 2013225021 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province I-ORG No. O 201602817 B-AWARD and O the O Shenyang B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG F16-102-4-00 O This O study O was O supported O by O the O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2014CB954100 O the O Large-scale B-ORG Scientific I-ORG Facilities I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Grant O No: O 2017-LSFGBOWS-01 B-AWARD Major B-ORG program I-ORG of I-ORG CAS I-ORG Kunming I-ORG Institute I-ORG of I-ORG Botany I-ORG 2014KIB02 O and O the O Applied B-ORG Fundamental I-ORG Research I-ORG Foundation I-ORG of I-ORG Yunnan I-ORG Province I-ORG 2014GA003 O This O work O was O supported O by O Natural B-ORG Science I-ORG Funding I-ORG of I-ORG China I-ORG 31671869 O 31471598 B-AWARD 31571852 B-AWARD and O 31601487 B-AWARD Natural B-ORG Science I-ORG Funding I-ORG of I-ORG Jiangsu I-ORG BK20151544 O Natural B-ORG Science I-ORG Funding I-ORG of I-ORG Zhejiang I-ORG LQ16C200002 O and O the O “333 B-ORG Project” I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BRA2017450 O This O work O was O supported O by O the O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG NIHR O Comprehensive O Biomedical O Research O Centre O at O Imperial O College O London O Grant O Ref O P45272 B-AWARD and O by O the O Genesis B-ORG Research I-ORG Trust I-ORG Grant O Ref O P51389 B-AWARD DAM O is O supported O by O a O Career O Development O Award O from O the O Medical B-ORG Research I-ORG Council I-ORG MR/L009226/1 O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 31160530 B-AWARD and I-AWARD 31360634 O the O Science B-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG of I-ORG Jiangxi I-ORG Province I-ORG 20122BBF60074 O and O the O Project B-ORG of I-ORG Education I-ORG Department I-ORG in I-ORG Jiangxi I-ORG Province I-ORG GJJ13289 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O Guangdong B-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG Funding O 2015A020213004 O 2013A020229005 B-AWARD and O 2014A040401041 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 11661026 O as O well O as O the O Guangxi B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2014GXNSFBA118016 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81360232 O Department B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Guiyang I-ORG City I-ORG 2019133 O 20199138 O and O Key B-ORG Laboratory I-ORG of I-ORG Adult I-ORG Stem I-ORG Cell I-ORG Transformation I-ORG Research I-ORG Chinese I-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences/Stem I-ORG Cell I-ORG and I-ORG Tissue I-ORG Engineering I-ORG Research I-ORG Center I-ORG Guizhou I-ORG Medical I-ORG University I-ORG 2018YB04 O The O funder O has O no O role O in O the O design O of O the O study O data O collection O and O analysis O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG grant O number O DFSA B-AWARD 201210 I-AWARD to O L.C.K O Cancer O Research O UK O grant O number O C1418/A414134 O to O J.W O and O a O Beeson O Career O Development O Award O from O the O American B-ORG Federation I-ORG for I-ORG Aging I-ORG Research I-ORG grant O number O K23AG040779 B-AWARD to O S.J.L O A.S O holds O the O British O Heart O Foundation O Chair O of O Psychology O at O University O College O London O The O English O Longitudinal O Study O of O Ageing O is O funded O by O the O National B-ORG Institute I-ORG on I-ORG Aging I-ORG grant O numbers O 2RO1AG7644-01A1 B-AWARD 2RO1AG017644 O and O a O consortium O of O UK O government O departments O coordinated O by O the O Office O for O National O Statistics O This O research O was O funded O by O grants O from O The B-ORG Key I-ORG research I-ORG and I-ORG development I-ORG project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2021C02054 O Key B-ORG Scientific I-ORG and I-ORG Technological I-ORG Grant I-ORG of I-ORG Zhejiang I-ORG for I-ORG Breeding I-ORG New I-ORG Agricultural I-ORG Varieties I-ORG 2021C02066-12 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2022YFD2200402 O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG High-end I-ORG Foreign I-ORG Expert I-ORG Introduction I-ORG Program I-ORG G2021016035L O “Pioneer” B-ORG and I-ORG “Leading I-ORG Goose” I-ORG R&D I-ORG Program I-ORG of I-ORG Zhejiang I-ORG 2022C02009 O The O authors O disclosed O receipt O of O the O following O financial O support O for O the O research O authorship O and/or O publication O of O this O article O Basic O Science O Research O Program O through O National O Research O Foundation O of O Korea O funded O by O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG ICT I-ORG NRF-2016R1A2B3009660;www.nrf.re.kr O to O H-IK O the O Biomedical O Integrated O Technology O Research O Project O through O a O grant O provided O by O Gwangju B-ORG Institute I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG NN16540;www.gist.ac.kr O to O H-IK O in O 2017 O and O the O Research B-ORG Institute I-ORG of I-ORG Clinical I-ORG Medicine I-ORG Chonnam I-ORG University I-ORG Hospital I-ORG CRI O 13072-3;www.cnuh.com O to O M-CL O This O work O is O supported O by O the O Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG 2019JDJQ0003 O Open B-ORG Project I-ORG Program I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Marine I-ORG Resource I-ORG Utilization I-ORG in I-ORG South I-ORG China I-ORG Sea I-ORG 2019010 O and O Dongguan B-ORG Introduction I-ORG Program I-ORG of I-ORG Leading I-ORG Innovative I-ORG and I-ORG Entrepreneurial I-ORG Talents I-ORG This O research O was O funded O by O the O FP7 B-ORG People I-ORG Marie-Curie I-ORG Actions I-ORG MRTN-CT-019564 O to O EFK O FP7 B-ORG Ideas I-ORG European I-ORG Research I-ORG Council I-ORG 283503 O to O KH O H2020 B-ORG European I-ORG Research I-ORG Council I-ORG 724703 O to O KH) O and O Deutsche B-ORG Forschungsgemeinschaft I-ORG DFG O FOR I-AWARD 2237 I-AWARD to O KH O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Project O 51801149 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Project O 2017M620448 B-AWARD and O the O Fund B-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG for I-ORG Strength I-ORG and I-ORG Vibration I-ORG of I-ORG Mechanical I-ORG Structures I-ORG Project O SV2019−KF−10 B-AWARD This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81774386 B-AWARD the B-ORG Fujian I-ORG Rehabilitation I-ORG Technology I-ORG of I-ORG Collaborative I-ORG Innovation I-ORG Center I-ORG Support I-ORG Project I-ORG Grant O Nos O X2012004 B-AWARD X2016001 B-AWARD and O X2017002 B-AWARD the O Fujian B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 2015J01335 B-AWARD Science B-ORG and I-ORG technology I-ORG innovation I-ORG platform I-ORG project I-ORG of I-ORG Fujian I-ORG University I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG Grant O No. O X2015024 B-AWARD This O study O was O sponsored O by O the O EuroQol B-ORG Research I-ORG Foundation I-ORG EQ O project I-AWARD 2016440 O to O HWL O Center B-ORG for I-ORG Drug I-ORG Evaluation I-ORG #10542652 O to O HWL O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Taiwan I-ORG NSC102-2320-B-039-007 O to O HWL O and O the O National B-ORG Health I-ORG Research I-ORG Institute I-ORG Taiwan I-ORG Grant O NHRI-EX103-10318PC O NHRI-EX104-10318PC O NHRI-EX105-10318PC O and O NHRI-EX106-10318PC B-AWARD to O HWL O in O the O preparation O and O implementation O stage O in O the O past O few O years O The O sponsors O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O The O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG 2016YFD0100202 O National O Key O Research O and O Development O Plan O 2018YFD0100500 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG XDJK2019C099 O the O Department O of O Agriculture O projects O of O modern O agricultural O technology O system O CARS-12 O CARS-13 O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31871653 O the O 111 O Project O B12006 O This O project O was O supported O by O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG U54GM111274 O the O National B-ORG Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases I-ORG U19AI117891 O and O the O National B-ORG Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute I-ORG U01HL139483 O This O research O was O funded O by O the O Basic B-ORG scientific I-ORG research I-ORG business I-ORG fee I-ORG youth I-ORG project I-ORG of I-ORG provincial I-ORG colleges I-ORG and I-ORG universities I-ORG in I-ORG Heilongjiang I-ORG Province I-ORG KYYWF10236180111 O the O Excellent B-ORG innovation I-ORG team I-ORG construction I-ORG project I-ORG of I-ORG basic I-ORG scientific I-ORG research I-ORG business I-ORG cost I-ORG of I-ORG colleges I-ORG and I-ORG universities I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG KYYWF10236190302 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG QC2017023 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 82173619 B-AWARD the O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation O grant O number O 2023A1515011242 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province O grant O number O 2020B1212030008 B-AWARD Supported O by O a O grant O U01 O IP000662 O from O the O Centers B-ORG for I-ORG Disease I-ORG Control I-ORG and I-ORG Prevention O The O views O expressed O herein O are O those O of O those O authors O and O not O those O of O the O Centers O for O Disease O Control O and O Prevention O Also O supported O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG UL1 O RR024153 I-AWARD and O UL1TR000005 B-AWARD and O by O the O National B-ORG Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases I-ORG R01 O AI116575 O This O work O was O supported O by O the O Carlos B-ORG Chagas I-ORG Filho I-ORG Foundation I-ORG for I-ORG Research I-ORG Support I-ORG of I-ORG Rio I-ORG de I-ORG Janeiro I-ORG State I-ORG FAPERJ)—Cientista I-ORG do I-ORG Nosso I-ORG Estado I-ORG CNE O grant O number O E-26/201.077/2021 B-AWARD Apoio B-ORG aos I-ORG Programas I-ORG e I-ORG Cursos I-ORG de I-ORG Pós-graduação I-ORG Stricto I-ORG Sensu I-ORG do I-ORG Estado I-ORG do I-ORG Rio I-ORG de I-ORG Janeiro I-ORG grant O number O E-26/210.136/2021 B-AWARD and O Rede B-ORG NanoSaude I-ORG grant O number O E-26/010.000981/2019 B-AWARD Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq)—Bolsa I-ORG Produtividade I-ORG em I-ORG Pesquisa I-ORG PQ-2 I-ORG grant O number O 309522/2020-0 B-AWARD to O Eduardo O Ricci-Júnior O This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0500502 O the B-ORG Special I-ORG Fund I-ORG for I-ORG Agro-scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG 201503134 O the B-ORG Program I-ORG for I-ORG Changjiang I-ORG Scholars I-ORG and I-ORG Innovative I-ORG Research I-ORG Team I-ORG in I-ORG University I-ORG IRT_17R50 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31660670 O and O the B-ORG Fund I-ORG of I-ORG Innovative I-ORG Talent I-ORG Cultivation I-ORG Lanzhou I-ORG University I-ORG 2022017zrit07 O This O work O was O supported O by O the O European B-ORG Commission I-ORG Horizon2020 O nr. O 660328 B-AWARD European B-ORG Regional I-ORG Development I-ORG Fund I-ORG MIND O nr. O 122035 B-AWARD and O the O Netherlands B-ORG Organisation I-ORG for I-ORG Scientific I-ORG Research I-ORG NWO-ALW O Open O Competition O nr. O 824.14.022 B-AWARD This O study O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31801406 O the O Hangzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Guidance I-ORG program I-ORG 20163501Y79 O the O Youth B-ORG Talent I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG 2016R25R08E01 O and O the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-16-S05 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O NO.61473176 O NO.61573225 O and O NO.61903226 O the O Taishan B-ORG Scholar I-ORG Project I-ORG of I-ORG Shandong I-ORG Province I-ORG Grant O NO.TSQN201812092 O Youth O Innovation O Technology O Project O of O Higher O School O in O Shandong O Province O Grant O NO.2019KJN005 O and O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG Grant O NO.2019GGX101072 O Agence B-ORG Nationale I-ORG de I-ORG la I-ORG Recherche I-ORG ANR O project O ANR-13-BSV5-0003-01 B-AWARD http://www.agence-nationale-recherche.fr O Conseil B-ORG Régional I-ORG d'Aquitaine I-ORG 20071303002PFM O http://www.aquitaine.fr O and O FEDER B-ORG 31486/08011464 O http://www.europe-en-france.gouv.fr/Configuration-Generale-Pages-secondaires/FEDER O are O also O acknowledged O for O their O financial O supports O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFB0700203 O National B-ORG Natural I-ORG Science I-ORG of I-ORG China I-ORG Grant O No O 51501106 B-AWARD The O Materials O Genome O Engineering O of O Rare O and O Precious O Metals O in O Yunnan O 2018ZE007 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG Grant O No. O 17ZR1440800 B-AWARD This O research O project O is O supported O by O a O cooperative O agreement O U01 O NS041588 O co-funded O by O the O National B-ORG Institute I-ORG of I-ORG Neurological I-ORG Disorders I-ORG and I-ORG Stroke I-ORG NINDS O and O the O National O Institute O on O Aging O NIA O National O Institutes O of O Health O Department O of O Health O and O Human O Service O and O investigator-initiated O grant O R01NS061846 B-AWARD from O the O NINDS O Additional O funding O was O supported O by O the O MOE B-ORG Ministry I-ORG of I-ORG Education I-ORG in I-ORG China I-ORG Project I-ORG of I-ORG Humanities I-ORG and I-ORG Social I-ORG Sciences I-ORG 20YJC890053 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG GK201803095 O and O an O unrestricted O research O grant O from O the O Coca-Cola O Company O The O funders O had O no O role O in O the O design O and O conduct O of O the O study O collection O management O analysis O and O interpretation O of O the O data O preparation O review O or O approval O of O the O manuscript O or O the O decision O to O submit O the O manuscript O for O publication O H2020 B-ORG Marie I-ORG Skłodowska-Curie I-ORG Actions I-ORG 713683 O COFUNDfellowsDTU O Environmental B-ORG Technology I-ORG Development I-ORG Program I-ORG MUDP O MST-141-01415 O Independent B-ORG Research I-ORG Fund I-ORG Denmark I-ORG DFF O 4184-00121B O Funding O for O open O access O charge O H2020 O Marie O Skłodowska-Curie O Actions O This O work O was O supported O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U1205122 O and O 31602207 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG 2016J05081 O National B-ORG ‘863’ I-ORG Project I-ORG of I-ORG China I-ORG 2012AA10A403 O and O the O Foundation B-ORG for I-ORG Innovation I-ORG Research I-ORG Team I-ORG of I-ORG Jimei I-ORG University I-ORG 2010A02 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O performed O in O the O State O Key O Laboratory O of O Kidney O Diseases O 2011DAV00088 O and O supported O by O the O Foundation B-ORG for I-ORG National I-ORG Clinical I-ORG Research I-ORG Center I-ORG 2015BAI12B06 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG 2016YFC1103004 O the O Four-hundred B-ORG Project I-ORG of I-ORG Chinese I-ORG PLA I-ORG General I-ORG Hospital I-ORG MJ201407 O the O Chinese B-ORG Academy I-ORG of I-ORG Engineering I-ORG Consulting I-ORG Research I-ORG Project I-ORG 2017-XZ-08 O and O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC0114503 O The O opinions O results O and O conclusions O reported O in O this O paper O were O those O of O the O authors O and O were O independent O from O the O funding O sources O This O work O was O supported O by O Zhejiang B-ORG Province I-ORG Health I-ORG Medicine I-ORG Science I-ORG and I-ORG Technology I-ORG Backbone I-ORG Platform I-ORG Project I-ORG 2016RCA004 O Youth B-ORG research I-ORG fund I-ORG project I-ORG of I-ORG Zhejiang I-ORG Cancer I-ORG Hospital I-ORG QN201804 O and O Zhejiang B-ORG Province I-ORG Health I-ORG Medicine I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG 2020KY082 O The O funding O body O played O no O role O in O the O design O of O study O collection O analysis O and O interpretation O of O data O or O in O writing O the O manuscript O This O research O was O funded O by O The O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 52178158 B-AWARD and O The O Excellent B-ORG Young I-ORG and I-ORG Middle-aged I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Team I-ORG Plan I-ORG of I-ORG Hubei I-ORG Provincial I-ORG Department I-ORG of I-ORG Education O grant O number O Zy2022e004 B-AWARD National B-ORG College I-ORG Students’ I-ORG innovation I-ORG and I-ORG entrepreneurship I-ORG training I-ORG program O grant O number O 202110488009 B-AWARD This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O nos O 31600792 B-AWARD and O 31771065 B-AWARD Post-Doctor B-ORG Research I-ORG Project I-ORG West I-ORG China I-ORG Hospital I-ORG Sichuan I-ORG University I-ORG no. O 2018HXBH053 B-AWARD 1.3.5 B-ORG project I-ORG for I-ORG disciplines I-ORG of I-ORG excellence I-ORG West I-ORG China I-ORG Hospital I-ORG Sichuan I-ORG University I-ORG ZYJC18002 O and O Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG 2019JDRC0020 O M.B.C-G O was O funded O by O the O Cambridge O Biomedical O Research O Centre O Metabolism O Endocrinology O and O Bone O theme O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG NIHR O grant O number O IS-BRC-1215-20014 B-AWARD and O Sparks B-ORG grant O number O 14CAM03 B-AWARD and O C.Z O and O R.J.M.F O by O the O Dr O Miriam O and O Shelson O G O Adelson O Medical O Research O Foundation O the O UK O Multiple O Sclerosis O Society O MS50 O and O a O core O support O grant O from O the O Wellcome B-ORG Trust I-ORG and O MRC O to O the O Wellcome O Trust-Medical O Research O Council O Cambridge O Stem O Cell O Institute O 203151/Z/16/Z O This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0100304 O 2017YFD0100402 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province O China O BK20160447 O the B-ORG Project I-ORG of I-ORG Breeding I-ORG of I-ORG Key I-ORG New I-ORG Varieties I-ORG in I-ORG Jiangsu I-ORG Province I-ORG PZCZ201702 O the B-ORG Jiangsu I-ORG Province I-ORG 333 I-ORG Project I-ORG BRA2016145 O the B-ORG Molecular I-ORG Breeding I-ORG Technology I-ORG Construction I-ORG of I-ORG Public I-ORG Service I-ORG Platform I-ORG Yangzhou I-ORG City I-ORG YZ2017170 O Yangzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Modern O Agriculture O YZ2018048 B-AWARD Rice B-ORG Industry I-ORG Technology I-ORG System I-ORG of I-ORG Yangzhou I-ORG Comprehensive I-ORG Experimental I-ORG Station I-ORG Yangzhou I-ORG Jiangsu I-ORG Province I-ORG China I-ORG CARS-01-60 O This O research O was O supported O by O the B-ORG National I-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG NIGMS-U01GM132771 O other B-ORG related I-ORG NIH I-ORG grants O are O also O recognized O e.g O U24MD015970 B-AWARD UL1TR002378 B-AWARD and O U54MD007584 B-AWARD We O also O acknowledge O the O support O of O the B-ORG 2019 I-ORG RCMI I-ORG Program I-ORG National I-ORG Conference O which O was O made O possible O in O part O by O grant O U13MD014961 B-AWARD This O study O was O supported O by O Science B-ORG and I-ORG Technology I-ORG Plan I-ORG Grant I-ORG of I-ORG Guangzhou I-ORG 201607010130 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2015A030313813 O The B-ORG Project I-ORG for I-ORG Key I-ORG Medicine I-ORG Discipline I-ORG Construction I-ORG of I-ORG Guangzhou I-ORG Municipality I-ORG 2017-2019-07 O and O Medical B-ORG and I-ORG Health I-ORG science I-ORG and I-ORG technology I-ORG Project I-ORG of I-ORG Guangzhou I-ORG 20171A011275).The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31271655 B-AWARD the O Project O Funded O by O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2015M580560 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG No. O 2016J01100 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81401682 O the O Programs B-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG of I-ORG Henan I-ORG Province I-ORG 172102310649 O and O the B-ORG Key I-ORG Scientific I-ORG Research I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG of I-ORG Henan I-ORG Province I-ORG 19B310006 O This O research O was O supported O by O grants O 2011E3300300 B-AWARD 2012E3301100 I-AWARD and I-AWARD 2013E3301600 I-AWARD from O Research B-ORG of I-ORG Korea I-ORG Centers I-ORG for I-ORG Disease I-ORG Control I-ORG and I-ORG Prevention O by O the B-ORG Pioneer I-ORG Research I-ORG Center I-ORG Program I-ORG through I-ORG the I-ORG National I-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG funded O by O the O Ministry O of O Science O ICT O Future O Planning O 2014M3C1A3053036 O and O Basic B-ORG Science I-ORG Research I-ORG Program I-ORG through I-ORG the I-ORG National I-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O funded O by O the O Ministry O of O Science O ICT O and O future O Planning O 2016R1A2B4007870 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O paper O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 71862026,http://www.nsfc.gov.cn O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018T110209,http://jj.chinapostdoctor.org.cn O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Inner I-ORG Mongolia I-ORG 2018MS07006,http://kjt.nmg.gov.cn O and O State B-ORG Scholarship I-ORG Found I-ORG of I-ORG China I-ORG Scholarship I-ORG Council I-ORG 201808155025,https://www.csc.edu.cn O Jianwei O Ren O received O these O awards O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Inner O Mongolia O Branch O of O Agricultural O Bank O of O China O provided O support O in O the O form O of O salaries O for O Chunhua O Chen O but O did O not O have O any O additional O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O specific O roles O of O these O authors O are O articulated O in O the O ‘author O contributions’ O section O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFA0301300 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O Nos.61671090 O and I-AWARD 61875021 O BUPT B-ORG Excellent I-ORG Ph.D I-ORG Students I-ORG Foundation I-ORG CX2018114 O Fund B-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Information I-ORG Photonics I-ORG and I-ORG Optical I-ORG Communications I-ORG IPOC20172204 O Guangxi O Key O Laboratory O of O Wireless O Wideband O Communication O and O Signal O Processing O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Beijing I-ORG 2192036 O This O work O was O supported O by O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG 2014A020212415 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017A030313664 O and O the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Guangzhou I-ORG Yuexiu I-ORG District I-ORG 2017-W O S-008 O to O XYP O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 71303161 B-AWARD 71503173 B-AWARD the O Youth B-ORG Project I-ORG of I-ORG the I-ORG Philosophy I-ORG and I-ORG Social I-ORG Science I-ORG Research I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG Grant O No. O 13YJC790057 B-AWARD the O Social B-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province I-ORG Grant O No. O L16BGL038 B-AWARD and O the O Program O for O Liaoning O Excellent O Talents O in O University O Grant O No. O WJQ2015026 B-AWARD This O work O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O No. O 62072319 B-AWARD the O Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG under O Grant O No. O 2023YFQ0022 B-AWARD and O No. O 2022YFG0041 B-AWARD the O Luzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG R&D I-ORG Program I-ORG No. O 2022CDLZ-6 B-AWARD This O research O was O funded O in O part O by O the O Million O Dollar O Bike O Ride O Orphan O Disease O Center O at O the O University O of O Pennsylvania O #MDBR-18-127-SR O to O R.A.C O the O National O Institutes O of O Health O National B-ORG Cancer I-ORG Institute I-ORG #R01CA204345 O to O R.A.C O the O National O Institutes O of O Health O National B-ORG Institute I-ORG of I-ORG Neurological I-ORG Disorders I-ORG and I-ORG Stroke I-ORG Grant O R01NS073854 O to O C.E.S O and O a O grant O from O the O South B-ORG Carolina I-ORG Department B-AWARD of I-AWARD Disabilities I-AWARD and I-AWARD Special I-AWARD Needs I-AWARD to O C.E.S O This O study O was O funded O by O Research B-ORG Foundation I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG of I-ORG Shaanxi I-ORG China I-ORG 2015SZS-15-05 O Collaborative B-ORG innovation I-ORG center I-ORG Research I-ORG Foundation I-ORG QBXT-Z(P)-15-28 O the B-ORG China I-ORG Scholarship I-ORG Council I-ORG CSC I-ORG Foundation I-ORG 201608615024 O Special B-ORG Scientists’ I-ORG Foundations I-ORG of I-ORG Shaanxi I-ORG University I-ORG of I-ORG Technology I-ORG SLGKYQD2014-2-18 O and O Research O Foundations O of O Shaanxi O University O of O Technology O SLGQD13-13 O AHA B-ORG development O grant O 14SDG20040003 O to O F.F O NIH-R35 B-ORG grant O GM118141 O to O A.B O MDA B-ORG grant O MDA-381828 O to O A.B O PAPIIT-UNAM B-ORG grant O IN209217 O to O X.P.M O Funding O for O open O access O charge O NIH-R35 O grant O GM118141 O This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 51802223 B-AWARD and O the O Project O Funded O by O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2016T90689 O 2015M580642 O and O Taizhou B-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG TG201817 O This O work O was O supported O by O the O Jilin B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG Grants O 20111807 B-AWARD and O 20140414014GH B-AWARD and O 20150101176 B-AWARD to O JWC O the O Platform B-ORG Construction I-ORG Project I-ORG of I-ORG Development I-ORG and I-ORG Reform I-ORG Commission I-ORG of I-ORG Jilin I-ORG Province I-ORG Grant O 2014N147 B-AWARD to O JWC O the B-ORG Bethune I-ORG Program I-ORG B I-ORG of I-ORG Jilin I-ORG University I-ORG Grant O 2012202 B-AWARD to O JWC O the O National B-ORG Major I-ORG Scientific I-ORG and I-ORG Technological I-ORG Special I-ORG Project I-ORG Grant O 2013ZX09102032 B-AWARD to O JTC O and O the B-ORG Key I-ORG Scientific I-ORG Project I-ORG of I-ORG Jilin I-ORG Province I-ORG 20140204024YY O to O JTC O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 61901056 B-AWARD the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Robotics I-ORG and I-ORG Systems I-ORG HIT O grant O no. O SKLRS-2021-KF-10 B-AWARD and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG CHD I-ORG grant O no. O 300102251203 B-AWARD The O study O was O supported O in O part O by O the O National B-ORG Space I-ORG Biomedical I-ORG Research I-ORG Institute I-ORG through O NCC B-AWARD 9-58 I-AWARD MB O Centers B-ORG of I-ORG Biomedical I-ORG Research I-ORG Excellence I-ORG P20 O GM109005 O MHJ O and O National B-ORG Institutes I-ORG of I-ORG Health I-ORG R01CA122023 O DZ O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0100301 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31701391 O 31701054 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG 2015CFA006 O This O work O was O supported O in O part O by O the O Anhui B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O 2108085MF200 B-AWARD in O part O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Provincial I-ORG Education I-ORG Department I-ORG under O Grant O no. O KJ2020A0307 B-AWARD and O in O part O by O Graduate B-ORG Innovation I-ORG Fund I-ORG of I-ORG Anhui I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG under O Grant O No. O 2022CX2082 B-AWARD This O work O was O supported O by O the O Guangdong B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG http://www.gdstc.gov.cn O through O grant O 2015A030313500 B-AWARD to O PG, O by O the O Provincial B-ORG Key I-ORG International I-ORG Cooperative I-ORG Research I-ORG Platform I-ORG and I-ORG the I-ORG Major I-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG Guangdong I-ORG Higher I-ORG Education I-ORG http://www.gdhed.edu.cn O through O grant O 2015KGJHZ015 B-AWARD to O PG, O and O by O the O Science B-ORG and I-ORG Technology I-ORG Plan I-ORG of I-ORG Guangdong I-ORG of I-ORG China I-ORG http://www.gdstc.gov.cn O through O grant O 2016B020201001 B-AWARD to O RL. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O Basic B-ORG Science I-ORG Special I-ORG Project I-ORG of I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2013FY110300 O the O Knowledge B-ORG Innovation I-ORG Project I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG KSCX2-EW-J-2 O and O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31572260 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Forestry B-ORG Science I-ORG I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG Shangdong I-ORG Province I-ORG LYCX01-2018-05 O to O KW; O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.31500264 O to O XG O and O the O Collection B-ORG and I-ORG Protection I-ORG of I-ORG Featured I-ORG Rare I-ORG and I-ORG Endangered I-ORG Forest I-ORG Tree I-ORG Germplasm I-ORG Resources I-ORG 2016LZGC038 O to O KW. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 31670710 B-AWARD 31670708 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Proj O No. I-AWARD 2015ZCQ-SB-02 O and O the O Beijing B-ORG Municipal I-ORG Science I-ORG I-ORG Technology I-ORG Commission I-ORG Z161100001116084 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Financial O support O from O FCT O – O Fundação B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG a I-ORG Tecnologia I-ORG through O the O project O UID/MAT/04674/2019 B-AWARD CIMA O Universidade O da O Madeira O and O the O Deutsche B-ORG Forschungsgemeinschaft I-ORG DFG-Research O Training I-AWARD Group I-AWARD 1932)Stochastic O Models O for O Innovations O in O the O Engineering O Sciencesis O gratefully O acknowledged O S. O Desmettre O is O also O supported O by O the O Austrian B-ORG Science I-ORG Fund I-ORG FWF O project O F5508-N26 B-AWARD which O is O part O of O the O Special O Research O ProgramQuasi-Monte O Carlo O Methods O Theory O and O Applications O Moreover O the O authors O gratefully O acknowledge O support O from O NAWI O Graz O The O present O study O was O financially O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grants I-ORG 31070744 O 81573561 I-AWARD and I-AWARD 81774000 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG South-Central I-ORG University I-ORG for I-ORG Nationalities I-ORG CZY20004 O CZP17060 I-AWARD and I-AWARD CZP17048 O Wuhan B-ORG Applied I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2017060201010217 O and O Fund B-ORG for I-ORG Key I-ORG Laboratory I-ORG Construction I-ORG of I-ORG Hubei I-ORG Province I-ORG Grant O No. O 2018BFC360 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the O Key B-ORG Project I-ORG for I-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0201900 O the O National B-ORG Natural I-ORG Science I-ORG Funds I-ORG of I-ORG China I-ORG 31621064 O the O State B-ORG Key I-ORG Laboratory I-ORG for I-ORG Biology I-ORG of I-ORG Plant I-ORG Diseases I-ORG and I-ORG Insect I-ORG Pests I-ORG SKLOF201708 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Financial O support O was O provided O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81460156 B-AWARD 81660363 B-AWARD 81260278 B-AWARD Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Leading I-ORG Academics I-ORG of I-ORG National I-ORG High-level I-ORG Personnel I-ORG of I-ORG Special I-ORG Support I-ORG Program I-ORG GKFZ-2018-29 O Guizhou B-ORG High-Level I-ORG Innovative I-ORG Talent I-ORG Support I-ORG Program I-ORG No. O QKH-RC-20154028 B-AWARD and O Science B-ORG and I-ORG Technology I-ORG Foundation I-ORG of I-ORG Guizhou I-ORG No. O QKH-2017-1422 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC1602800 O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U1603112 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20180038 O BK20171461 B-AWARD the B-ORG Six I-ORG Talent I-ORG Peaks I-ORG Project I-ORG in I-ORG Jiangsu I-ORG Province I-ORG 2015-JY-009 O and O the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2012AA021705 O This O research O benefitted O from O funding O from O the O National B-ORG Research I-ORG Foundation I-ORG South O Africa O grant O no. O 74691 B-AWARD the O Oppenheimer B-ORG Memorial I-ORG Trust I-ORG OMT O ref O 19671/02 B-AWARD the O former O Institute O for O Geo O and O Bioarchaeology O of O the O Vrije O Universiteit O Amsterdam O and O the O Centre O for O International O Cooperation O CIS O of O the O Vrije O Universiteit O Amsterdam O Ref O Mbeki O GRD O is O funded O by O the O European B-ORG Research I-ORG Council I-ORG under I-ORG the I-ORG European I-ORG Union's I-ORG Seventh I-ORG Framework I-ORG Programme I-ORG FP7/2007-2013 O O ERC B-ORG Synergy I-ORG grant I-ORG agreement O no O 319209 B-AWARD This O present O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 81770803 B-AWARD key B-ORG Program I-ORG of I-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Education I-ORG Committee I-ORG grant O no. O KJ2019A0353 B-AWARD Science B-ORG and I-ORG Technology I-ORG Development I-ORG Fund I-ORG of I-ORG the I-ORG First I-ORG Affiliated I-ORG Hospital I-ORG of I-ORG Bengbu I-ORG Medical I-ORG College I-ORG grant O no. O BYYFYKJ201716 B-AWARD and O Key B-ORG Project I-ORG of I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Bengbu I-ORG Medical I-ORG College I-ORG grant O no. O BYKY1736ZD B-AWARD The O funding O body O played O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81670329 O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG CIFMS O Nos O 2016-I2M-1-011 B-AWARD 2016-I2M-3-011 B-AWARD and O National B-ORG Key I-ORG R&D I-ORG Programs I-ORG of I-ORG China I-ORG 2017YFC1103603 O This O research O was O supported O by O the O MN O Futures O Program O of O the O University O of O Minnesota O by O the O Skippy O Frank O Fund O for O Life O Sciences O and O Translational O Research O by O Morris B-ORG Animal I-ORG Foundation I-ORG Grant O D15CA-047 B-AWARD and O by O the O Animal O Cancer O Care O and O Research O Program O of O the O University O of O Minnesota O The O Spanish O Government O is O acknowledged O for O funding O under O the O project O number O MAT2017-83631-C3 O The O Basque B-ORG Government I-ORG is O acknowledged O for O funding O under O the O project O number O IT1245-19 B-AWARD Portions O of O this O work O were O conducted O in O the O Minnesota O Nano O Center O which O is O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG through O the O National O Nano O Coordinated O Infrastructure O Network O NNCI O under O Award O Number O ECCS-1542202 B-AWARD 1) O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81472058 B-AWARD 2) O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Plan I-ORG of I-ORG Hunan I-ORG No. O 2018SK2105 B-AWARD 3) O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Plan I-ORG of I-ORG Changsha I-ORG No. O KQ1606001 B-AWARD 4) O The B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG Central I-ORG South I-ORG University I-ORG No. O 2019ZZTS809 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O the O Project B-ORG of I-ORG Zhejiang I-ORG Science I-ORG and I-ORG technology I-ORG 2015C37022 O the O Medical B-ORG Health I-ORG Platform I-ORG Program I-ORG of I-ORG Zhejiang I-ORG China I-ORG 2013ZD025 O and O the O Zhejiang B-ORG research I-ORG project I-ORG of I-ORG commonweal I-ORG technology I-ORG 2017C33186 O This O study O was O supported O by O Key B-ORG R&D I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2020C03010 O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21575128 O and O 81773632 B-AWARD and O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG LZ19H300001 O This O research O was O supported O by O a O grant O NRF-2020R1A2C1007473 O from O the O Basic O Science O Research O Program O through O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea O funded O by O the O Ministry O of O Education O Science O and O Technology O It O was O also O supported O by O the O Commercialization’s B-ORG Promotion I-ORG Agency I-ORG for I-ORG R&D I-ORG Outcomes I-ORG COMPA O grant O funded O by O the O Korean O government O MSIT O No. O 2022C100 B-AWARD Chonnam B-ORG National I-ORG University I-ORG Grant O number O 2019-0234 B-AWARD and O Chonnam B-ORG National I-ORG University I-ORG Hospital I-ORG Biomedical I-ORG Research I-ORG Institute I-ORG grant O No. O CRI18035-1 B-AWARD This O research O was O funded O by O the O Major B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Inner I-ORG Mongolia I-ORG Autonomous I-ORG Region I-ORG grant O number O 2020ZD0003-3 B-AWARD “Assume B-ORG Leadership” I-ORG Project I-ORG of I-ORG Inner I-ORG Mongolia I-ORG Autonomous I-ORG Region I-ORG grant O number O 2022JBGS0024-03 B-AWARD National B-ORG Key I-ORG R&D I-ORG Program I-ORG Supported I-ORG Project I-ORG grant O number O 2021YFD1300902 B-AWARD This O work O was O supported O by O grants O from O Jiangsu B-ORG Province’s I-ORG Key I-ORG Provincial I-ORG Talents I-ORG Program I-ORG No.ZDRCA201604 O the B-ORG “333 I-ORG high I-ORG level I-ORG talents I-ORG Project” I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O BRA2015326 B-AWARD and O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81570363 B-AWARD and O Shanghai B-ORG Hospital I-ORG Development I-ORG Center I-ORG Project I-ORG SHDC12017X24 O The O funders O had O no O role O in O the O data O analysis O and O manuscript O preparation O This O work O has O been O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG nos O 61673143 B-AWARD and O 31671187 B-AWARD the O Postdoctoral B-ORG Scientific I-ORG Research I-ORG Developmental I-ORG Fund O no. O LBH-Q16166 B-AWARD and O the O University B-ORG Nursing I-ORG Program I-ORG for I-ORG Young I-ORG Scholars I-ORG with I-ORG Creative I-ORG Talents I-ORG in I-ORG Heilongjiang I-ORG Province O no. O UNPYSCT-2017061].Conflict B-AWARD of O interest O None O declared O SP O supported O by O National B-ORG Multiple I-ORG Sclerosis I-ORG Society I-ORG Project O Grant O no. O RG4398A1/1 B-AWARD International O Progressive O Multiple O Sclerosis O Alliance O Challenge O Award O no. O PA0065 O Multiple B-ORG Sclerosis I-ORG Research I-ORG Australia I-ORG and O Trish O Multiple O Sclerosis O Research O Foundation O no. O 15-022 B-AWARD and O Bethlehem B-ORG Griffiths I-ORG Research I-ORG Foundation I-ORG no. O BGRF1706 B-AWARD This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32101975 O 32022066 B-AWARD Modern B-ORG Agricultural I-ORG Technical I-ORG Foundation I-ORG of I-ORG China I-ORG CARS-42-25 O Zhejiang B-ORG Province I-ORG Natural I-ORG Science I-ORG Foundation I-ORG LQ22C200017 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Ningbo I-ORG 2022J086 O The O work O received O financial O support O from O the O São B-ORG Paulo I-ORG Research I-ORG Foundation I-ORG FAPESP O Process O 2018/06739-1 B-AWARD This O study O was O financed O in O part O by O the O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior—Brasil I-ORG CAPES)—Finance O Code O 001 B-AWARD Mike O T. O John O was O supported O by O the O National B-ORG Institute I-ORG of I-ORG Dental I-ORG and I-ORG Craniofacial I-ORG Research I-ORG of I-ORG the I-ORG National I-ORG Institutes I-ORG of I-ORG Health I-ORG USA O under O the O Award O Number O R01DE028059 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81703709 B-AWARD 81703425 B-AWARD the O Project B-ORG Funds I-ORG from I-ORG Science I-ORG and I-ORG Technology I-ORG Council I-ORG of I-ORG Liaoning I-ORG Province I-ORG No. O 2010225034 B-AWARD and O the O Doctoral B-ORG Start-up I-ORG Fund I-ORG Program I-ORG of I-ORG Liaoning I-ORG Province I-ORG China I-ORG No. O 201601186 B-AWARD California B-ORG Institute I-ORG of I-ORG Regenerative I-ORG Medicine I-ORG GC1R-06673-C O to O M.H O National B-ORG Institutes I-ORG of I-ORG Health I-ORG 5U54HG007990-04 O National B-ORG Human I-ORG Genome I-ORG Research I-ORG Institute I-ORG 2U41HG002371-18 O Funding O for O open O access O charge O Chan-Zuckerberg B-ORG Initiative O grant O 182809 B-AWARD This O study O was O support O by O a O grant O from O Nanjing B-ORG City I-ORG Committee I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 201503013 O a O grant O from O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20161107 O a O grant O from O Jiangsu B-ORG Provincial I-ORG Department I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG LZ13182 O and O a O grant O from O Key B-ORG Project I-ORG of I-ORG Nanjing I-ORG Municipal I-ORG Health I-ORG Bureau I-ORG zkx13022 O All O these O funding O bodies O provided O necessary O financial O support O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O This O work O was O supported O by O COLCIENCIAS B-ORG Colombia O Grant O 120340820464 B-AWARD Pontificia B-ORG Universidad I-ORG Javeriana O Bogotá O D.C O Colombia O Grant O 00004554 B-AWARD and O by O Michael O E. O DeBakey O Veterans O Affairs O Medical O Center O Internal O Project O and O the O Baylor O College O of O Medicine O United O States O Dr. O Graham O was O supported O in O part O by O the O Office B-ORG of I-ORG Research I-ORG and I-ORG Development I-ORG Medical I-ORG Research I-ORG Service I-ORG Department I-ORG of I-ORG Veterans I-ORG Affairs O Public O Health O Service O Grant O DK56338 B-AWARD which O funds O the O Texas B-ORG Medical I-ORG Center I-ORG Digestive I-ORG Diseases I-ORG Center I-ORG and O DK067366 B-AWARD This O study O was O supported O by O grant O from O the O National B-ORG Science I-ORG Foundation I-ORG for I-ORG Young I-ORG Scientists I-ORG of I-ORG China I-ORG grant O no. O 81800325 B-AWARD and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 81270286 B-AWARD Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangzhou I-ORG City I-ORG grant O no. O 201906010089 B-AWARD The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O the O decision O to O publish O or O the O preparation O of O the O manuscript O The O work O was O not O funded O by O any O industry O sponsors O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O 61662069 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG under O Grant O 2017M610817 B-AWARD and O the B-ORG Foundation I-ORG for I-ORG Excellent I-ORG Young I-ORG Teachers I-ORG by I-ORG Northwest I-ORG Normal I-ORG University I-ORG under O Grant O NWNU-LKQN-14-7 B-AWARD This O research O was O funded O by O Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG ZR2020MF091 O Key B-ORG Lab I-ORG of I-ORG Intelligent I-ORG and I-ORG Green I-ORG Flexographic I-ORG Printing I-ORG ZBKT202101 O Qilu B-ORG University I-ORG of I-ORG Technology I-ORG Shandong I-ORG Academy I-ORG of I-ORG Sciences I-ORG Pilot I-ORG Project I-ORG for I-ORG Integrating I-ORG Science I-ORG Education I-ORG and I-ORG Industry I-ORG 2022PX078 O A O Project O of O Shandong B-ORG Province I-ORG Higher I-ORG Educational I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG J17KA178 O Foundation O ZZ20210108 O of O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Biobased I-ORG Material I-ORG and I-ORG Green I-ORG Papermaking I-ORG Qilu I-ORG University I-ORG of I-ORG Technology I-ORG Shandong I-ORG Academy I-ORG of I-ORG Sciences I-ORG This O study O was O funded O in O part O by O Qatar B-ORG National I-ORG Research I-ORG Fund’s I-ORG National I-ORG Priorities I-ORG Research I-ORG Program I-ORG NPRP11S-0110-180250 O and O Path B-ORG to I-ORG Precision I-ORG Medicine I-ORG Program I-ORG PPM1-1229-15002 O and O Sidra B-ORG Medicine’s I-ORG Precision I-ORG Medicine I-ORG Program I-ORG Internal I-ORG Research I-ORG Fund I-ORG IRF O 2019 O SDR200054 B-AWARD and O SDR400034 B-AWARD This O work O was O financially O supported O by O the O National B-ORG Major I-ORG New I-ORG Drugs I-ORG Innovation I-ORG and I-ORG Development I-ORG 2017ZX09301060 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC1708004 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31370379 O the O Special O Fund O for O Basic O Scientific O Research O of O Central O Colleges O South-Central O University O for O Nationalities O CZP18004 O and O Hubei O Provincial O Technical O Innovation O Program O 2017AHB067 O Partially O supported O by O Deutsche B-ORG Forschungsgemeinschaft I-ORG SFB-TR36 O T.B O Deutsche B-ORG Krebshilfe I-ORG 111546 O T.B O and O the O Berlin B-ORG Institute I-ORG of I-ORG Health I-ORG CRG-1 O T.B O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O Humanities B-ORG and I-ORG Social I-ORG Sciences I-ORG Fund I-ORG 20YJC630238 O funded O by O China’s O Ministry O of O Education.http://www.moe.gov.cn O YZ O received O the O funding O This O research O also O was O supported O by O Decision-making B-ORG Consultation I-ORG Program I-ORG 2019-A-016 O and O University B-ORG Thinkbank I-ORG Content I-ORG Building I-ORG Project I-ORG 2019 O XUANCHUAN I-AWARD 1-2 O funded O by O Shanghai O government.http://www.fzzx.sh.gov.cn O andwww.shanghai.gov.cn O HL O received O the O fundings O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O in O part O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81502144 O 81472369 B-AWARD Beijing B-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospitals I-ORG Clinical I-ORG Medicine I-ORG Development I-ORG of I-ORG Special I-ORG Funding I-ORG Support I-ORG ZYLX201508 O Beijing B-ORG Health I-ORG System I-ORG Top I-ORG Level I-ORG Health I-ORG Technical I-ORG Personnel I-ORG Training I-ORG Plan I-ORG 20153079 O This O work O was O supported O by O Cancer B-ORG Research I-ORG UK I-ORG grant O no. O C570/A16491 B-AWARD the O UK O Medical B-ORG Research I-ORG Council I-ORG grant O no. O MR/K02700X/1 B-AWARD and O the O Wellcome B-ORG Trust O Our O Planet O Our O Health O Livestock O Environment O and O People—LEAP O award O number O 205212/Z/16/Z B-AWARD K.E.B O is O supported O by O the O Girdlers O New O Zealand O Health O Research O Council O Fellowship O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O authors O had O full O access O to O the O data O and O analyses O and O were O solely O responsible O for O the O decision O to O submit O for O publication O This O study O was O funded O by O the B-ORG National I-ORG Key I-ORG R I-ORG I-ORG D I-ORG Program I-ORG of I-ORG China I-ORG 2019YFC1605402 O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31372454 O and O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grants O 81130079 B-AWARD and O 91232302 B-AWARD to O Y.M O L), O the O Key B-ORG Project I-ORG of I-ORG United I-ORG Fund I-ORG of I-ORG National I-ORG Natural I-ORG and I-ORG Guangdong I-ORG Province I-ORG U1301223 O to O H.Y O S), O and O the O Medical B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG A2016304 O to O S. O W). O This O work O was O supported O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No. O 3332022159 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Sichuan I-ORG Grant O No. O 2019YFS0105 B-AWARD the O Fundamental O Research O Funds O for O the O Central O Universities O Grant O No. O 3332018126 B-AWARD and O the O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG Grant O No. O CIFMS B-AWARD 2021-I2M-1-060 B-AWARD This O work O was O supported O by O Taiwan B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG grant I-ORG MOST104-2628-B-039-001-MY4 O Taiwan B-ORG Ministry I-ORG of I-ORG Health I-ORG and I-ORG Welfare I-ORG Clinical I-ORG Trial I-ORG and I-ORG Research I-ORG Center I-ORG of I-ORG Excellence I-ORG grant I-ORG MOHW105-TDU-B-212-133019 O National O Health O Research O Institute O NHRI-EX107-10705BI O and O China B-ORG Medical I-ORG University I-ORG grant I-ORG CMU105-S-41 O This O work O was O supported O by O theNational O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China(NSFC O 51371176 O 51571197 B-AWARD and O 51671194 B-AWARD and O theFrontier O Science I-ORG Key I-ORG Programs I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences(QYZDJ-SSW-JSC010 O Dong O Chen O was O supported O by O the O Special O Program O for O Applied O Research O onSuper O Computation I-ORG of I-ORG the I-ORG NSFC-Guangdong I-ORG Joint I-ORG Fund(the O second O phase O under O Grant O No. O U1501501 B-AWARD This O work O was O supported O by O European B-ORG Community's I-ORG Research I-ORG Infrastructure I-ORG Action I-ORG 262044 B-AWARD Mr. O Agoston O Torok O and O Elena O Kokkinara O Magyar B-ORG Tudományos I-ORG Akadémia I-ORG HU) I-ORG Young B-AWARD Researcher I-AWARD Fellowship I-AWARD Mr. O Agoston O Torok O European B-ORG Union I-ORG Seventh I-ORG Framework I-ORG Programme I-ORG EU I-ORG FP7 I-ORG vere B-AWARD wp1 I-AWARD Dr. O Elisa O Raffaella O Ferré O and O Prof O Patrick O Haggard O BIAL B-ORG 269/14 B-AWARD Dr. O Elisa O Raffaella O Ferré O and O Prof O Patrick O Haggard O Economic B-ORG and I-ORG Social I-ORG Research I-ORG Council I-ORG Professorial B-AWARD Fellowship I-AWARD Prof O Patrick O Haggard O European B-ORG Research I-ORG Council I-ORG Advanced B-AWARD Grant I-AWARD HUMVOL I-AWARD Prof O Patrick O Haggard O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61966035 O and O 62266043 B-AWARD the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U1803261 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG XinJiang I-ORG Uygur I-ORG Autonomous I-ORG Region I-ORG 2021D01C077 O and O the O Autonomous B-ORG Region I-ORG Graduate I-ORG Innovation I-ORG Project I-ORG XJ2019G069 O XJ2021G062 B-AWARD and O XJ2020G074 B-AWARD This O study O was O jointly O supported O by O The B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0506603 O Bureau B-ORG of I-ORG International I-ORG Co-operation I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG 132C35KYSB20150005 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41661144032 O and O Chinese O Academy O of O Sciences-The O World O Academy O of O Sciences O CAS−TWAS O President’s O Fellowship O Program O for O international O Ph.D O students O at O University O of O Chinese O Academy O of O Sciences O UCAS O China O This O work O was O supported O by O JSPS B-ORG KAKENHI I-ORG grant O no. O JP B-AWARD 20K09824 O a O Grant B-ORG on I-ORG Rare I-ORG and I-ORG Intractable I-ORG Diseases I-ORG from I-ORG the I-ORG Ministry I-ORG of I-ORG Health I-ORG Labour I-ORG and I-ORG Welfare I-ORG of I-ORG Japan I-ORG grant O no. O 22FC0201 B-AWARD and O a O Research B-ORG Program I-ORG on I-ORG Emerging I-ORG and I-ORG Re-emerging I-ORG Infectious I-ORG Diseases I-ORG grant I-ORG from I-ORG the I-ORG Japan I-ORG Agency I-ORG for I-ORG Medical I-ORG Research I-ORG and I-ORG Development I-ORG AMED I-ORG grant O no. O JP21fk0108124j B-AWARD This O project O was O supported O by O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2014CB138501 O the O 948 B-ORG Program I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Agriculture I-ORG of I-ORG China I-ORG 2012-G1(4 O and O the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2011AA100301 O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O numbers O 22207020 B-AWARD and O U1812403 B-AWARD Guizhou B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Projects O grant O numbers O QKHJC-ZK[2021]ZD017 B-AWARD QKHZC[2022]YB191 B-AWARD QKHJC-ZK B-AWARD 2022]YB392 O and O QKHZYD[2022]4015 B-AWARD “Light B-ORG of I-ORG the I-ORG West” I-ORG Talent I-ORG Cultivation I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences O grant O numbers O RZ B-AWARD 2022]4 I-AWARD for O L. O Wang O GMU B-ORG J O 2020]006 I-AWARD 19NSP078 I-AWARD 20NSP065 O and O 100 B-ORG Leading I-ORG Talents I-ORG of I-ORG Guizhou I-ORG Province I-ORG for O W. B-AWARD Zhu I-AWARD This O work O was O supported O by O the O National B-ORG Key I-ORG R I-ORG I-ORG D I-ORG projects I-ORG in I-ORG China I-ORG 2016YFA0600801 O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 O Program O 2015CB150802 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31470527 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O in O part O by O a O National B-ORG Science I-ORG Foundation I-ORG Grant O MCB1412411 O a O Laboratory O Directed O Research O and O Development O Program O of O Lawrence B-ORG Berkeley I-ORG National I-ORG Laboratory I-ORG under I-ORG U.S I-ORG Department I-ORG of I-ORG Energy I-ORG Contract O No. O DE-AC02-05CH11231 B-AWARD and O USDA B-ORG National I-ORG Institute I-ORG of I-ORG Food I-ORG and I-ORG Agriculture I-ORG Hatch O project O CA-B-MIC-0129-H B-AWARD to O NLG O This O research O was O funded O by O the O National B-ORG Nature I-ORG Science I-ORG Fund I-ORG of I-ORG China I-ORG 62103297 O 61973227 B-AWARD and O 52072408 B-AWARD the O Young B-ORG Elite I-ORG Scientists I-ORG Sponsorship I-ORG Program I-ORG by I-ORG CAST I-ORG YESS20210078 O the O Guangxi B-ORG Key I-ORG Laboratory I-ORG of I-ORG Automatic I-ORG Detecting I-ORG Technology I-ORG and I-ORG Instruments I-ORG YQ22206 O and O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Dynamic I-ORG Measurement I-ORG Technology I-ORG North I-ORG University I-ORG of I-ORG China I-ORG 2022-SYSJJ-09 O This O trial O was O supported O by O the O the O CAMS B-ORG Initiative I-ORG for I-ORG Innovative I-ORG Medicine I-ORG grant O number O 2016-I2M-1-001 B-AWARD the O National B-ORG Key I-ORG Projects I-ORG of I-ORG Research I-ORG and I-ORG Development I-ORG of I-ORG China I-ORG grant O number O 2016YFC0904600 B-AWARD and O Non-profit B-ORG Central I-ORG Research I-ORG Institue I-ORG Fund I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG grant O number O 2018PT32011 B-AWARD This O research O was O funded O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program O grant O number O 2018YFD1000200 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 31672102 B-AWARD and O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation O grant O numbers O 2015M580881 B-AWARD and O 2016T90952 B-AWARD The O authors O work O in O this O field O has O been O supported O by O grants O from O theMedical O Research I-ORG Council(G1100357 O to O RAA),Medical O Research I-ORG Scotland(354FRG O to O AJC O and O theRoyal O Society(RG140503 O to O AJC O This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0501009 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31272620 O and O the B-ORG Chengdu I-ORG Giant I-ORG Panda I-ORG Breeding I-ORG Research I-ORG Foundation I-ORG CPF2015-4 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O project O was O funded O by O a O grant O from O the O Agency B-ORG for I-ORG Healthcare I-ORG Research I-ORG and I-ORG Quality I-ORG U19HS021114 B-AWARD to O PI O Carole O Lannon O for O “Pursuing O Perfection O in O Pediatric O Therapeutics.” O Dr. O Brinkman O was O supported O by O Award O Number O K23MH083027 B-AWARD from O the O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health O Dr. O Lipstein O was O supported O by O award O number O K23HD073149 B-AWARD from O the O Eunice B-ORG Kennedy I-ORG Shriver I-ORG National I-ORG Institute I-ORG of I-ORG Child I-ORG Health I-ORG and I-ORG Human I-ORG Development O The O funding O sources O had O no O role O in O study O design O in O the O collection O analysis O and O interpretation O of O data O in O the O writing O of O the O report O and O in O the O decision O to O submit O the O article O for O publication O This O study O was O supported O by O grants O from O the B-ORG medical-engineering I-ORG cross I-ORG fund I-ORG of I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG No. O YG2017MS13 B-AWARD the O International B-ORG Foundation I-ORG of I-ORG Translational I-ORG Medicine I-ORG for I-ORG abroad I-ORG Scholars I-ORG and I-ORG Students I-ORG U.S I-ORG and I-ORG China I-ORG No. O UCTMP2015-03C001 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81272401 B-AWARD and O the B-ORG pre-research I-ORG fund I-ORG of I-ORG Shanghai I-ORG sixth I-ORG People’s I-ORG Hospital I-ORG LYZY-0229 O The O Project O Supported O by O Medical B-ORG Scientific I-ORG and I-ORG Technology I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG Grant O No. O A2017569 B-AWARD Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG Grant O No. O JCYJ20170307095222274 B-AWARD and O Health B-ORG and I-ORG Family I-ORG Commission I-ORG of I-ORG Shenzhen I-ORG Municipality I-ORG Foundation I-ORG Grant O No. O SZBC2017002 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 51672220 O and O 111 B-ORG Program I-ORG B08040 O of O MOE O the O National B-ORG Defense I-ORG Science I-ORG Foundation I-ORG 32102060303 O the O Xi'an B-ORG Science I-ORG and I-ORG Technology I-ORG Foundation I-ORG the I-ORG Shaanxi I-ORG Provincial I-ORG Science I-ORG Foundation I-ORG and I-ORG NPU I-ORG Gaofeng I-ORG Project O 17GH020824 O of O China O This O work O was O supported O by O grants O from O the O Anhui B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG Demonstration I-ORG Project I-ORG No. O 201707d08050003 B-AWARD and O the O Anhui B-ORG Province I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG No. O 201904a07020032 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O Nos O 81570403 B-AWARD 81371284 B-AWARD and O U1732157 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Program B-ORG of I-ORG Excellent I-ORG Innovation I-ORG Talents I-ORG Guizhou I-ORG Province I-ORG No. O 20154021 B-AWARD the O Program B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Talents I-ORG Team I-ORG Guizhou I-ORG Province I-ORG No. O 20144001 B-AWARD the O Key B-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG in I-ORG Guizhou I-ORG Province I-ORG NY O 2010 I-AWARD 3026 O and O the O International B-ORG Cooperation I-ORG Base I-ORG for I-ORG Insect I-ORG Evolutionary I-ORG Biology I-ORG and I-ORG Pest I-ORG Control I-ORG No. O 20165802 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG to O JS O No. O 31571188 B-AWARD to O XHJ O No. O 31071012 B-AWARD and O to O FFL O No. O 31570906 B-AWARD from O the O Scientific B-ORG Research I-ORG Program I-ORG of I-ORG Shaanxi I-ORG Provincial I-ORG Education I-ORG Department I-ORG to O XHJ O No. O 18JK1197 B-AWARD and O from O the O Natural B-ORG Science I-ORG Basic I-ORG Research I-ORG Plan I-ORG in I-ORG Shaanxi I-ORG Province I-ORG of I-ORG China I-ORG to O JS O No. O 2014JZ2-004 B-AWARD These O funding O bodies O had O no O role O in O design O of O the O study O in O collection O analysis O and O interpretation O of O the O data O and O in O writing O the O manuscript O This O research O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2022YFC2302702 O the O Project B-ORG of I-ORG the I-ORG Priority I-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O and O the O 111 O Project O D18007 B-AWARD the O Development B-ORG Grant I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Infectious I-ORG Disease I-ORG Prevention I-ORG and I-ORG Control I-ORG 2015SKLID505 O and O the O United B-ORG States I-ORG National I-ORG Institutes I-ORG of I-ORG Health I-ORG U01 I-ORG AI151810 O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21971212 O Key B-ORG Project I-ORG of I-ORG Innovation I-ORG Research I-ORG 2035 I-ORG Pilot I-ORG Plan I-ORG of I-ORG Southwest I-ORG University I-ORG SWU-XDZD22007 O Chongqing B-ORG Special I-ORG Foundation I-ORG for I-ORG Postdoctoral I-ORG Research I-ORG Proposal I-ORG Xm2015031 O This O work O was O supported O by O the O Shenghua B-ORG Professorship I-ORG Supporting I-ORG grant I-ORG from I-ORG Central I-ORG South I-ORG University I-ORG No. O 202033001 O Guoqing O Hu, O Xunjie O Cheng O Liheng O Tan O Innovation B-ORG Fund I-ORG for I-ORG graduate I-ORG students I-ORG of I-ORG Central I-ORG South I-ORG University I-ORG No. O 2018zzts845 B-AWARD Liheng O Tan O and O NIH/NIAID B-ORG grant O R37-AI32042-19 B-AWARD Yang O Yang O There O was O no O additional O external O funding O received O for O this O study O The O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 21705072 B-AWARD Colleges B-ORG and I-ORG Universities I-ORG in I-ORG Henan I-ORG Province I-ORG Key I-ORG Science I-ORG and I-ORG Research I-ORG Project I-ORG No. O 17A150039 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province I-ORG 20180550016 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O Grant O Number O 52100071 B-AWARD Natural O Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grants O No O BK20181466 B-AWARD People’s B-ORG Livelihood I-ORG Projects I-ORG of I-ORG Suzhou I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG Grants O No O SS2019028 B-AWARD and O Environmental B-ORG Protection I-ORG Project I-ORG from I-ORG Suzhou I-ORG Ecological I-ORG and I-ORG Environmental I-ORG Protection I-ORG Bureau I-ORG Grants O No O B201903 B-AWARD Foreign B-ORG Cooperation I-ORG Project I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2012DFA30490 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2014AA020606 O and O Beijing O Municipal B-ORG Administration I-ORG of I-ORG Hospitals I-ORG Clinical I-ORG Medicine I-ORG Development I-ORG of I-ORG Special I-ORG Funding I-ORG Support I-ORG ZYLX201713 O play O important O roles O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O Svenska B-ORG Lakaresallskapet I-ORG 2018 O SLS-788751 B-AWARD Bengt B-ORG Ihres I-ORG foundation I-ORG 2018 O SLS-788731 B-AWARD Gastrologisk B-ORG forskningsfond I-ORG 2018 O SLS-783091 B-AWARD These O were O not O involved O in O the O study O design O collecting O or O interpreting O the O data O or O drafting O the O manuscript O This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81471900 O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2015A030311001 O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG 201508020262 O This O work O was O supported O by O the O Nankai O laboratory O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. B-AWARD 21777113 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Tianjin I-ORG City I-ORG Grant O No. B-AWARD 15JCQNJC08800 O the O National B-ORG Undergraduate I-ORG Training I-ORG Programs I-ORG for I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG No. O 201610060037 I-AWARD and I-AWARD 201710060027 O and O the O Training O Project O of O the O Innovation O Team O of O Colleges O and O Universities O in O Tianjin O And O the O grant O recipient O is O corresponding O author O Lei O Huang O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O grants O from O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O No. O 2016YFD0101400 B-AWARD the B-ORG National I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG Transgenic I-ORG Crops I-ORG of I-ORG China I-ORG grant O No. O 2016ZX08005005 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O Nos O 31621005 B-AWARD and O 31701474 B-AWARD This O research O was O funded O by O Universidad B-ORG de I-ORG Buenos I-ORG Aires I-ORG grants O 20020170100339BA B-AWARD and O 20020170100065BA B-AWARD National B-ORG Research I-ORG Council I-ORG of I-ORG Argentina I-ORG CONICET I-ORG grant O number O 11220200100114CO B-AWARD National B-ORG Agency I-ORG of I-ORG Scientific I-ORG and I-ORG Technical I-ORG Research I-ORG grant O number O PICT-2020-00437 B-AWARD and O European B-ORG Regional I-ORG Development I-ORG Fund I-ORG grant O number O ED431C B-AWARD 2018/05 O This O work O is O supported O by O the O European O Community O under O the10.13039/501100010767Innovative O Medicines I-ORG Initiative(IMI O Programme O through O Grant O Agreement O number O 115336 B-AWARD MIP-DILI O andJanssen O PharmaceuticaN.V O agreement O ICD O 387882 B-AWARD as O part O of O the O Drug O Safety O Centre O supported O by O the10.13039/501100000265Medical O Research I-ORG Council[grant O number O G0700654 B-AWARD to O LK O OD] O was O funded O by O an O MRC O Case O Award O in O collaboration O with O AstraZeneca O This O work O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31271925 O and O the O Special B-ORG Project I-ORG on I-ORG the I-ORG Integration I-ORG of I-ORG Industry I-ORG Education I-ORG and I-ORG Research I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG No. O 2013B090600015 O as O well O as O the O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG China I-ORG No. O 2014J4100192 O M. O C. O Otero O Consejo O de O Investigaciones O de O la O Universidad O Nacional O de O Tucumán O PIUNT O 2018 O 26/D645 B-AWARD and O PIUNT B-ORG 2014 O D527)http://scait.ct.unt.edu.ar/programas-y-proyectos-de-investigacion B-AWARD Agencia O Nacional O de O Promoción O Científica O y O Tecnológica O PICT O 2014-1334)http://www.agencia.mincyt.gob.ar/frontend/agencia/instrumento/24 B-AWARD This O study O was O supported O by O Key B-ORG Research I-ORG Program I-ORG of I-ORG Frontier I-ORG Sciences I-ORG CAS I-ORG QYZDJ-SSW-SMC027 O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2017YFA0605100 B-AWARD and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31330008 B-AWARD This O study O was O funded O by O NSFC O National O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China)-Yunnan O Joint O Fund O Grant O No. O U1302262 B-AWARD Science B-ORG and I-ORG Technology I-ORG Basic I-ORG Resources I-ORG Investigation I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2017FY100100 B-AWARD National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2017YFC0505200 B-AWARD Yunnan B-ORG Science I-ORG and I-ORG Technology I-ORG Talents I-ORG and I-ORG Platform I-ORG Program I-ORG for I-ORG Key I-ORG Laboratory I-ORG Construction I-ORG Grant O No. O 2018DG004 B-AWARD Yunnan O Science O and O Technology O Innovation O Team O Program O for O PSESP O Plant O Species I-ORG with I-ORG Extremely I-ORG Small I-ORG Populations O Conservation O and O Utilization O Grant O No. O 2019HC015 B-AWARD and O STS O Program O of O the O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG “Full O Cover O Conservation O Project O of O Native O Plants O in O Southwestern O China” O KFJ-3W-No1 O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG 2016YFD0500606 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31800105 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2018A030310486 O ‘Climbing B-ORG plan’ I-ORG supported I-ORG by I-ORG Guangdong I-ORG University I-ORG students’ I-ORG Special I-ORG Fund I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG and I-ORG Cultivation I-ORG pdjh2020b0043 O Guangdong B-ORG Provincial I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG Project I-ORG 2019B020212002 O This O research O was O supported O by O funds O from O the O Translational B-ORG Medicine I-ORG Special I-ORG Foundation I-ORG of I-ORG China I-ORG Russia I-ORG Medical I-ORG Research I-ORG Center I-ORG no. O 201519 I-AWARD and I-AWARD CR1418 O the O T B-ORG echnological I-ORG and I-ORG Innovative I-ORG Talent I-ORG Foundation I-ORG of I-ORG Harbin I-ORG 2012RFXXS041 O and O the O Hai B-ORG Yan I-ORG Foundation I-ORG of I-ORG the I-ORG Cancer I-ORG Hospital I-ORG of I-ORG Harbin I-ORG Medical I-ORG University I-ORG JJQN2016-02 O This O material O is O based O upon O work O supported O by O the O National B-ORG Oceanic I-ORG and I-ORG Atmospheric I-ORG Administration I-ORG Chesapeake O Bay O Office O https://chesapeakebay.noaa.gov O grant O number O NA11NMF4570218 B-AWARD RDS O the O Environmental B-ORG Protection I-ORG Agency I-ORG EPA O STAR O Fellowship O https://www.epa.gov/research-fellowships/science-achieve-results-star-graduate-fellowships O under O grant O number O FP91767501 B-AWARD CNG O and O the O National B-ORG Science I-ORG Foundation I-ORG Administration O GK-12 O program O http://www.vims.edu/education/graduate/gk12/fellows/index.php O under O grant O number O DGE-0840804 B-AWARD CNG O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Number O 81202127 B-AWARD the B-ORG Zhejiang I-ORG Medical I-ORG and I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Plans I-ORG Grant O Numbers O 2012KYA031 B-AWARD and O 2013KYB033 B-AWARD and O the B-ORG Zhejiang I-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O Number O LY16H160036 B-AWARD This O article O was O made O open O access O with O the O financial O support O of O King’s O College O London O This O study O was O supported O financially O by O the B-ORG National I-ORG Key I-ORG Laboratory I-ORG Breeding I-ORG Base I-ORG of I-ORG Dermatology I-ORG of I-ORG China I-ORG 4601007103 O the B-ORG Key I-ORG Laboratory I-ORG of I-ORG Dermatology I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG 4601007102 O and O the B-ORG Cultivation I-ORG of I-ORG fund I-ORG winners I-ORG of I-ORG innovative I-ORG research I-ORG groups I-ORG 4601011224 O This O research O was O supported O by O Basic O Science O Research O Program O through O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O funded O by O the O Ministry O of O Education O 2017R1D1A1B03030060 O the B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG ICT I-ORG MSIT O 2012K1A4A3053142 O and O by O a O grant O of O the O Korea O Health O Technology O R&D O Project O through O the O Korea O Health O Industry O Development O Institute O KHIDI O funded O by O the O Ministry B-ORG of I-ORG health I-ORG I-ORG Welfare I-ORG Republic I-ORG of I-ORG Korea I-ORG grant O number O HI15C1524 B-AWARD FW O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61472086 O and O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0902100 O RC O was O supported O by O the O Retinal B-ORG Research I-ORG Foundation I-ORG Foundation I-ORG Fighting I-ORG Blindness I-ORG BR-GE-0613-0618-BCM O and O the O National B-ORG Eye I-ORG Institute I-ORG R01EY022356 O R01EY018571 B-AWARD R01EY020540 B-AWARD This O research O was O funded O by O the O Austrian B-ORG Science I-ORG Fund I-ORG FWF O I2463-B21 B-AWARD the O German B-ORG Research I-ORG Foundation I-ORG DFG O 407626949 B-AWARD and O the O Research B-ORG Foundation I-ORG Flanders I-ORG FWO O Vlaanderen O This O work O was O funded O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 30901356 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No.3082008 O Ph.D O Programs B-ORG Foundation I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG No.20090141120014 O and O Research B-ORG Foundation I-ORG of I-ORG Health I-ORG Department I-ORG of I-ORG Hubei I-ORG Province I-ORG No. O JX4B67 B-AWARD The O study O sponsors O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Anming O Yu O is O employed O by O Stago O Diagnosis O Company O Stago O Diagnosis O Company O provided O support O by O the O supply O of O partial O D-dimer O testing O reagents O and O some O technic O support O and O paid O the O salary O for O author O AY, O but O did O not O have O any O additional O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Anming O Yu O is O the O one O who O supported O technical O support O This O specific O role O of O this O author O is O articulated O in O the O ‘author O contributions’ O section O This O work O was O supported O by O the O CIHR B-ORG Foundation I-ORG Grant I-ORG Program I-ORG 201610FDN-375469 O CIHR/IDRC B-ORG team I-ORG grant I-ORG 149783 O and O the O Canada B-ORG Research I-ORG Chair I-ORG Program I-ORG CIHR O 950-231075 O to O K.P O This O research O was O funded O by O grants O from O the O British B-ORG Heart I-ORG Foundation I-ORG ref O PG/11/51/28986 B-AWARD and O SP B-AWARD 14/4/31123 O The O funder O had O no O involvement O in O data O analysis O data O interpretation O or O writing O of O the O paper O DAL O works O in O a O unit O that O receives O funding O from O the O University O of O Bristol O and O UK O Medical B-ORG Research I-ORG Council I-ORG MC_UU_1201/5 O she O is O also O a O UK B-ORG National I-ORG Institute I-ORG of I-ORG Health I-ORG and I-ORG Research I-ORG Senior O Investigator O NF-SI-0166-10196 O This O work O is O supported O by O the O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Plan I-ORG of I-ORG Southwest I-ORG Hospital I-ORG No. O SWH2016ZDCX2014 O and O SWH2016JCYB-04 B-AWARD Third B-ORG Military I-ORG Medical I-ORG University I-ORG Foundation I-ORG Grant O No. I-AWARD 2016XPY12 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51703243 O This O work O was O partly O supported O by O funds O of O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG MOST O 111-2320-B-037-015-MY3 O the O National B-ORG Sun I-ORG Yat-sen I-ORG University–KMU I-ORG Joint I-ORG Research I-ORG Project I-ORG #NSYSUKMU O 112-P06 O the O Kaohsiung B-ORG Medical I-ORG University I-ORG KMU-DK(A)112008 O and O the O Kaohsiung B-ORG Medical I-ORG University I-ORG Research I-ORG Center I-ORG KMU-TC108A04 O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 21878152 B-AWARD No. O 21776133 O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O 55129017 O Jiangsu B-ORG Province I-ORG Policy I-ORG Guidance I-ORG Program I-ORG No. O BZ2018025 B-AWARD Nanjing B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG No. O 201818026 B-AWARD and O The B-ORG Jiangsu I-ORG Synergetic I-ORG Innovation I-ORG Center I-ORG for I-ORG Advanced I-ORG Bio-Manufacture I-ORG No. O XTB1804 B-AWARD This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31601520 B-AWARD the O Technology B-ORG Innovation I-ORG Fund I-ORG of I-ORG Chongqing I-ORG Grant O No. O cstc2016shms-ztzx80005 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG funded I-ORG project I-ORG Grant O No. O 2016M592620 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No. O XDJK2016C060 B-AWARD and O SWU115083 B-AWARD and O the O Chongqing B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG funded O project O Grant O No. O Xm2016119 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O project O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 61805053 B-AWARD the O Guangxi B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG Grant O Nos O AD19110038 B-AWARD AD19110003 B-AWARD the O Scientific B-ORG Research I-ORG Foundation I-ORG of I-ORG Guangxi I-ORG Education I-ORG Department I-ORG Grant O No. O 2019KY03927 B-AWARD the O Scientific B-ORG Research I-ORG Foundation I-ORG of I-ORG Guangxi I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Grant O No. O 19Z07 B-AWARD and O the B-ORG Innovation I-ORG Project I-ORG of I-ORG Guangxi I-ORG Graduate I-ORG Education I-ORG Grant O No. O YCSW2021135 B-AWARD This O research O was O funded O by O the B-ORG Shenzhen I-ORG Key I-ORG Laboratory I-ORG of I-ORG Renal O grant B-AWARD number I-AWARD ZDSYS201504301616234 O Youth B-ORG Research I-ORG Cadre I-ORG Cultivation I-ORG Project I-ORG of I-ORG Shenzhen I-ORG People’s I-ORG Hospital O grant B-AWARD number I-AWARD SYKYPY201904 O and O Guangdong B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG China O grant B-AWARD number I-AWARD A2019416 I-AWARD Thanks O for O support O of O Study B-ORG and I-ORG demonstration I-ORG of I-ORG high I-ORG efficiency I-ORG planting I-ORG technology I-ORG of I-ORG alfalfa I-ORG in I-ORG Zhongyuan I-ORG humid I-ORG region(No.201403048-6 O China B-ORG Forage I-ORG and I-ORG Grass I-ORG Research I-ORG System(No.CARS-34)and O The B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.31172261 O Hongqi O Du O designed O the O experiment O performed O most O of O the O research O analyzed O the O data O and O drafted O the O manuscript O Yinghua O Shi O plays O role O in O drafting O and O revising O the O manuscript O Chengzhang O Wang O designed O the O experiment O supervised O the O study O and O revised O the O manuscript.Defeng O Li, O Wenna O Fan,Yanhua O Wang O and O Guoqiang O Wang O give O some O helps O in O the O process O of O study O Support O was O provided O by O the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Shanxi I-ORG Province I-ORG Grant O No. O 20140313013-5 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanxi I-ORG Province I-ORG Grant O No. O 201701D221173 B-AWARD http://www.sxinfo.gov.cn O Shanxi B-ORG Province I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG Science I-ORG and I-ORG Technology I-ORG Grant O No. O 201601054 B-AWARD http://www.sxwsjs.gov.cn O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81770802 O and O 81270397 B-AWARD National B-ORG Key I-ORG R I-ORG I-ORG D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC1309601 O and O Shanghai B-ORG Municipal I-ORG Education I-ORG Commission-Gaofeng I-ORG Clinical I-ORG Medicine I-ORG Grant I-ORG Support I-ORG 20152232 O This O research O has O been O carried O out O in O the O context O of O a O project O funded O by O the O “Plan O Nacional I-ORG Sobre I-ORG Drogas” O of O the O Spanish B-ORG “Ministerio I-ORG de I-ORG Sanidad” I-ORG 2020/021 O within O the O SUN O Project O which O since O its O inception O has O also O received O other O funding O from O the O Government B-ORG of I-ORG Navarra I-ORG 24/1999 O 96/2000 B-AWARD 36/2001 B-AWARD 43/2002 B-AWARD 36/2008 B-AWARD 45/2011 B-AWARD 7/2011 B-AWARD 122/2014 B-AWARD the O “Instituto O de I-ORG Salud I-ORG Carlos I-ORG III” O 01/0619 O PI030678 B-AWARD PI040233 B-AWARD PI050976 B-AWARD PI070240 B-AWARD PI070312 B-AWARD PI081943 B-AWARD PI042241 B-AWARD PI080819 B-AWARD PI1002293 B-AWARD PI1002658 B-AWARD RD06/0045 B-AWARD PI13/00615 B-AWARD PI14/01668 B-AWARD PI14/01798 B-AWARD PI14/01764 B-AWARD PI17/01795 B-AWARD PI20/00564 B-AWARD and O the O “Plan O Nacional O Sobre O Drogas” O 2010/087 O as O well O as O the O University O of O Navarra O itself O In O addition O the O principal O investigator O of O the O article O has O carried O out O this O research O thanks O to O an O FPU O grant O Formación O de O Profesorado O Universitario O from O the O Spanish B-ORG “Ministerio I-ORG de I-ORG Universidades” I-ORG FPU20/05413 O This O work O was O supported O by O the O Medical B-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Foshan I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG Foshan I-ORG City I-ORG China I-ORG Grant O No. I-AWARD 20190260 O and O the O Foshan B-ORG Science I-ORG and I-ORG Technology I-ORG Bureau O Foshan O City O China O Grant O No. I-AWARD 2220001004005 O We O thank O LetPub B-ORG www.letpub.com O for O its O linguistic O assistance O during O the O preparation O of O this O manuscript O Contract O No. O PR_230111J463Y B-AWARD Supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO.81571425 O NO. B-AWARD 81771566 O Scientific B-ORG and I-ORG Technological I-ORG Research I-ORG Program I-ORG of I-ORG Chongqing I-ORG Municipal I-ORG Education I-ORG Commission I-ORG KJ1600229 B-AWARD Postgraduate B-ORG scientific I-ORG research I-ORG innovation I-ORG project I-ORG of I-ORG Chongqing I-ORG Medical I-ORG university(CYB16105 O This O research O is O supported O by O the O Humanities B-ORG and I-ORG Social I-ORG Sciences I-ORG planning I-ORG funds I-ORG project I-ORG under I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG the I-ORG PRC I-ORG grant O no. O 17YJCZH047 B-AWARD Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG grant O no. O 9174041 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG grant O no. O 2-9-2015-303 B-AWARD and O the O fund O from O Key B-ORG Laboratory I-ORG of I-ORG Carrying I-ORG Capacity I-ORG Assessment I-ORG for I-ORG Resource I-ORG and I-ORG Environment I-ORG Ministry I-ORG of I-ORG Land I-ORG and I-ORG Resources I-ORG grant O no. O CCA2017.11 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 82172229 B-AWARD No. O 81971851 B-AWARD Natural B-ORG Science I-ORG Basic I-ORG Research I-ORG Plan I-ORG in I-ORG Shaanxi I-ORG Province I-ORG of I-ORG China I-ORG No. O 2022JM-600 B-AWARD and O the O Foundation B-ORG of I-ORG Xijing I-ORG Hospital I-ORG Grants I-ORG No. O XJZT21CM33 B-AWARD This O work O was O supported O by O UNLP B-ORG X053 O X701 B-AWARD CONICET O PIP O 2051 O ANPCyT B-ORG PICT O 2019-2322 O PICT B-AWARD 2017-2251 O PICT B-AWARD 2016-4597 O and O the O Spanish B-ORG Government I-ORG RTI2018-095038-B-I00 O We O acknowledge O support O from O Australian B-ORG Research I-ORG Council I-ORG grant O nos O FL160100168 B-AWARD FL150100133 I-AWARD FT170100254 I-AWARD and I-AWARD FT140101062 O Leverhulme B-ORG Trust I-ORG RPG-2015-422 B-AWARD and I-AWARD EM-2017-047/4 O and O NERC B-ORG NE/K008862/1 B-AWARD The O work O is O supported O by O the O State B-ORG Administration I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG project I-ORG 201507003 O Also O funded O by O National B-ORG Nature I-ORG Fund I-ORG 81503515 O Also O funded O by O the O Science B-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2014A020221088 O This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG Grant O No. O 2018YFB0803402 B-AWARD and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanxi I-ORG Province I-ORG Grant O No. O 201701D111002 B-AWARD and O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shanxi I-ORG Province I-ORG Grant O No. O 201903D121121 B-AWARD This O research O was O funded O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O number O 2019YFB1600500 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 51775053 B-AWARD the O Key O Research O and O Development O Program O of O Shannxi O grant O number O 2019ZDLGY03-09-02 O and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG grant O number O CHD B-AWARD 300102220202 O This O study O was O supported O in O part O by O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81830064 O 81721092 B-AWARD and O 81701906 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG 2017YFC1103300 O Funds B-ORG Chinese I-ORG PLA I-ORG General I-ORG Hospital I-ORG for I-ORG Military I-ORG Medical I-ORG Innovation I-ORG Research I-ORG Project I-ORG CX19026 O the O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG CIFMS O 2019-I2M-5-059 B-AWARD and O the O Military B-ORG Medical I-ORG Research I-ORG and I-ORG Development I-ORG Projects I-ORG AWS17J005 O 2019–126 B-AWARD and O Fostering O Funds O of O Chinese O PLA O General O Hospital O for O National B-ORG Distinguished I-ORG Young I-ORG Scholar I-ORG Science I-ORG Fund I-ORG 2017-JQPY-002 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.21804045 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG No. O 2018J05020 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Xiamen I-ORG City I-ORG No.3502Z20183027 O and O 3502Z20183040 O Electronic O Information O and O Control O of O Fujian O University O Engineering O Research O Center O Minjiang O University O No. O 2018-MS5-129 O Promotion O Program O for O Young O and O Middle-aged O Teacher O in O Science O and O Technology O Research O of O Huaqiao O University O ZQN-PY612 O This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2016YFE0113300 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2016M591306 B-AWARD the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG Grant O No. O ASTIP-FRI07 B-AWARD and O the O Fundamental O Research O Funds O for O Central O Non-profit O Scientific O Institution O Grant O No. O 1610382018003 B-AWARD and O the O Foundation O of O Key O Laboratory O of O Industrial O Fermentation O Microbiology O of O Ministry O of O Education O and O Tianjin O Key O Lab O of O Industrial O Microbiology O Tianjin O University O of O Science O O Technology O Grant O No. O 2017KF002 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China–Henan I-ORG Joint I-ORG Fund I-ORG U2004147 O Joint B-ORG Funds I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG and I-ORG Henan I-ORG Province I-ORG U22A20537 O Higher B-ORG Education I-ORG School I-ORG Young I-ORG Backbone I-ORG Teacher I-ORG Training I-ORG Program I-ORG of I-ORG Henan I-ORG Province I-ORG 2021GGJS096 O and O Key O Research I-ORG and I-ORG Development I-ORG and I-ORG Promotion I-ORG Project I-ORG in I-ORG Henan I-ORG Province I-ORG 222102110089 O This O work O was O funded O by O the O U.S O National B-ORG Science I-ORG Foundation I-ORG Award O No. O 1030845 B-AWARD to O TBC O and O TTV O www.nsf.gov O Australian B-ORG Research I-ORG Council I-ORG Award O DP170101288 B-AWARD to O TTV O www.arc.gov.au O and O Joint B-ORG Fire I-ORG Science I-ORG Program I-ORG Graduate O Research O Innovation O Award O 17-2-01-4 B-AWARD KR O and O TTV O www.firescience.gov O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG China I-ORG Grant O Number O 328201911 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG under O Grant O F2019402206 B-AWARD the O Research B-ORG Program I-ORG for I-ORG Top-notch I-ORG Young I-ORG Talents I-ORG in I-ORG Higher I-ORG Education I-ORG Institutions I-ORG of I-ORG Hebei I-ORG Province O China O under O Grant O BJ2017037 B-AWARD Natural O Science O Foundation O of O China O No.61971032 O and O the O Fundamental O Research O Funds O for O the O Central O Universities O No.FRF-TP-18-008A3 O The O APC O was O funded O by O Fundamental O Research O Funds O for O the O Central O Universities O of O China O Grant O and O Higher O Education O Department O of O the O Ministry O of O Education O Industry-university O Cooperative O Education O Project O The O research O was O supported O by O the O grants O no. O 61106127 B-AWARD from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O no. O 2013CFA088 B-AWARD from O the O Science B-ORG Foundation I-ORG of I-ORG Educational I-ORG Commission I-ORG of I-ORG Hubei I-ORG Province I-ORG of I-ORG China I-ORG and O no. O 2015D-5006-0404 B-AWARD from O Petro B-ORG China I-ORG Innovation I-ORG Foundation I-ORG This O work O was O funded O in O part O by O the O following O grants O Agency B-ORG for I-ORG Health I-ORG Care I-ORG Research I-ORG and I-ORG Quality I-ORG www.ahrq.gov O HS09699 B-AWARD National B-ORG Center I-ORG for I-ORG Injury I-ORG Prevention I-ORG and I-ORG Control I-ORG https://www.cdc.gov/injury O CE001589 B-AWARD UC B-ORG Center I-ORG for I-ORG Health I-ORG Quality I-ORG and I-ORG Innovation I-ORG health.universityofcalifornia.edu/innovation-center O HL120466 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Major I-ORG Development I-ORG Program I-ORG of I-ORG Transgenic I-ORG Breeding I-ORG 2014ZX0800953B O the O National B-ORG Natural I-ORG Science I-ORG Foundations I-ORG of I-ORG China I-ORG 31661143013 O the O State B-ORG High-tech I-ORG Development I-ORG Plan I-ORG 2013AA102503 O and O the O National O Natural O Science O Foundations O of O China O 31272419 O Funding O for O open O access O charge O Ministry O of O Agriculture O of O China O MAS O acknowledges O financial O support O by O the O EPSRC-funded O UCL B-ORG Centre I-ORG for I-ORG Doctoral I-ORG Training I-ORG in I-ORG Medical I-ORG Imaging I-ORG EP/L016478/1 O AA O holds O an O MRC O eMedLab O Medical O Bioinformatics O Career O Development O Fellowship O This O work O was O supported O by O the O Medical B-ORG Research I-ORG Council I-ORG grant O number O MR/L016311/1 B-AWARD The O research O leading O to O these O results O has O received O funding O from O the O program O “Investissements O d’avenir” O ANR-10-IAIHU-06 B-AWARD Agence O Nationale O de O la O Recherche-10-IA O Institut O Hospitalo-Universitaire-6 O and O from O the O “Contrat O d’Interface O Local” O program O to O OC) O from O Assistance O Publique-Hôpitaux O de O Paris O AP-HP O Data O and/or O research O tools O used O in O the O preparation O of O this O manuscript O were O obtained O and O analyzed O from O the O controlled O access O datasets O distributed O from O the O NIMH-supported O research O Domain O Criteria O Database O RDoCdb O RDoCdb O is O a O collaborative O informatics O system O created O by O the O National O Institute O of O Mental O Health O to O store O and O share O data O resulting O from O grants O funded O through O the O Research O Domain O Criteria O RDoC O project O Dataset O identifier(s O 2607 O Data O collection O and O sharing O for O this O project O was O funded O by O the O Pediatric O Imaging O Neurocognition O and O Genetics O Study O PING O National O Institutes O of O Health O Grant O RC2DA029475 O IMAGEN O was O supported O by O the O European O Union-funded O FP6 O LSHM-CT-2007-037286 O The O funders O had O no O role O in O study O design O data O collection O except O for O PING O and O IMAGEN O grants O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O project O was O supported O by O the O Scientific B-ORG Research I-ORG Topics I-ORG of I-ORG Jiangsu I-ORG Provincial I-ORG Health I-ORG Commission I-ORG No. O H2018027 O the O Science B-ORG and I-ORG Education I-ORG to I-ORG Promote I-ORG Health I-ORG of I-ORG Suzhou I-ORG KJXW2016034 O and O the B-ORG Suzhou I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Plan I-ORG Project I-ORG SYSD2018146 O This O research O was O funded O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province O No: O 2022-MS-363 B-AWARD Basic B-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG Education I-ORG Department I-ORG of I-ORG Liaoning I-ORG Province O No: O LJKMZ20220735 B-AWARD Shenyang B-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG No: O 20-205-4-070 B-AWARD This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 20976097 B-AWARD 21076116 B-AWARD and O 21211120165 B-AWARD 21311120297 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2018MEE048 O and O the O PetroChina B-ORG Innovation I-ORG Foundation I-ORG 2010D-5006-0405 O This O work O was O supported O by O the O Development B-ORG of I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG under O grants O 2014CB910402 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O grants O No. O 31870923 O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG under O grants O 2017YFF0205404 O and O the O Beijing B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG under O grants O Z181100003818023 O This O research O was O funded O by O the O Scientific B-ORG Research I-ORG Foundation I-ORG of I-ORG Third I-ORG Institute I-ORG of I-ORG Oceanography I-ORG Ministry I-ORG of I-ORG Natural I-ORG Resources I-ORG MNR O No. O 2016019 B-AWARD the O Fujian B-ORG Natural I-ORG Science I-ORG Foundation I-ORG China I-ORG No. O 2021J011190 B-AWARD the O high-level B-ORG talents I-ORG research I-ORG project I-ORG of I-ORG Xiamen I-ORG University I-ORG of I-ORG Technology I-ORG No. O YKJ20004R B-AWARD and O the O Fujian B-ORG educational I-ORG research I-ORG projects I-ORG of I-ORG young I-ORG and I-ORG middle-aged I-ORG teachers I-ORG No. O JAT200453 B-AWARD This O work O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 82172206 B-AWARD Zhejiang B-ORG Provincial I-ORG Medical I-ORG and I-ORG Healthy I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 2023RC183 B-AWARD and O Zhejiang B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG China I-ORG LGF22H150002 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31770774 O the O Provincial B-ORG Major I-ORG Project I-ORG of I-ORG Basic I-ORG or I-ORG Applied I-ORG Research I-ORG in I-ORG Natural I-ORG Science O Guangdong O Provincial O Education O Department O 2016KZDXM038 O and O the O Higher B-ORG Education I-ORG Reform I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2019268 O The O funder O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the O Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG grant O number O 2021YJ0375 B-AWARD the O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG CAS I-ORG “Light I-ORG of I-ORG West I-ORG China” I-ORG Program I-ORG grant O number O E0R2170 B-AWARD and O the O Youth B-ORG Fund I-ORG of I-ORG Institute I-ORG of I-ORG Mountain I-ORG Hazards I-ORG and I-ORG Environment I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG grant O number O SDS-QN-1904 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 22135001 O and O 22075315 B-AWARD the O Youth B-ORG Innovation I-ORG Promotion I-ORG Association I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG 2019317 O and O the O Scientific O Experimental O System O in O Near O Space O of O the O Chinese O Academy O of O Sciences O XDA17020304 O This O study O was O supported O by O the O Grant O from O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG No. O 2016YFC0906102 B-AWARD three O Grants O from O the O National B-ORG Natural I-ORG Science I-ORG Fund I-ORG Nos O 81870478 B-AWARD 81425008 B-AWARD and O 81621092 B-AWARD and O the O Grant O from O Peking B-ORG University I-ORG Health I-ORG Science I-ORG Center I-ORG No. O BMU2017CJ002 B-AWARD This O work O was O supported O by O the O Wellcome B-ORG Trust I-ORG 107392 O This O work O was O also O conducted O using O the O UK B-ORG Biobank I-ORG Resource I-ORG under O Application O Number O 23773 B-AWARD R.N.H O is O funded O by O the O Medical B-ORG Research I-ORG Council I-ORG SUAG/010 O RG91365 O The O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81470093 O and I-AWARD 81672025 O Jiangsu B-ORG Province’s I-ORG Outstanding I-ORG Medical I-ORG Academic I-ORG Leader I-ORG Program I-ORG LJ201154 O Jiangsu B-ORG Province’s I-ORG Clinical I-ORG Medicine I-ORG and I-ORG Technology I-ORG Special I-ORG Program I-ORG BL2012034 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG for I-ORG Young I-ORG Scholar I-ORG BK20160121).The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O in O part O by O the O Grants-in-Aid O for O Brain O Mapping O by O Integrated O Neurotechnologies O for O Disease O Studies O 15653129 O a O Grant-in-Aid O for O Scientific O Research O C O 15K09977 O to O YK O and O Grants-in-Aid O for O Young O Scientists O B O 16K19790 O to O MK O and O 16K19789 B-AWARD to O KT) O from O the O Japan B-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science O Research O and O Development O Grants O for O Dementia O 16768966 O from O the O Japan B-ORG Agency I-ORG for I-ORG Medical I-ORG Research I-ORG and I-ORG Development O and O Core B-ORG Research I-ORG for I-ORG Evolutional I-ORG Science I-ORG and I-ORG Technology I-ORG JPMJCR1652 O from O the O Japan O Science O and O Technology O Agency O The O funders O had O no O role O in O the O design O and O conduct O of O the O study O collection O management O analysis O and O interpretation O of O the O data O preparation O review O or O approval O of O the O manuscript O and O decision O to O submit O the O manuscript O for O publication O This O work O was O supported O by O the O Doctoral B-ORG Funding I-ORG of I-ORG Inner I-ORG Mongolia I-ORG Minzu I-ORG University I-ORG BS660 O Outstanding B-ORG Talents I-ORG of I-ORG Henan I-ORG Agricultural I-ORG University I-ORG 30500996 O Key B-ORG Scientific I-ORG Research I-ORG Projects I-ORG of I-ORG Colleges I-ORG and I-ORG Universities I-ORG in I-ORG Henan I-ORG Province I-ORG 23A230008 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32202877 O and O the O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Fund I-ORG of I-ORG Henan I-ORG Agricultural I-ORG University I-ORG KJCX2021A06 O Bong-Sung O Kim O is O supported O by O “START,” O a O program O for O young O scientists O of O the O Medical B-ORG Faculty I-ORG at I-ORG the I-ORG RWTH I-ORG Aachen I-ORG University I-ORG Project O number O 691346 B-AWARD START I-AWARD 2013-2 O and O the O Research O Fellowship O Program O of O the O German B-ORG Research I-ORG Foundation I-ORG Deutsche I-ORG Forschungsgemeinschaft I-ORG DFG O GZ: O KI B-AWARD 1973/1-1 O Norbert O Pallua O is O supported O by O DFG O grant O PA B-AWARD 1271/5-1 O Jürgen O Bernhagen O is O supported O by O DFG O grants O SFB1123/P03 B-AWARD SFB/TRR57-P07 B-AWARD and O DFG O BE1977/7-1 B-AWARD as O well O as O by O DFG O within O the O framework O of O the O Munich O Cluster O for O Systems O Neurology O EXC O 1010 O SyNergy O Richard O Bucala O is O supported O by O National B-ORG Institute I-ORG of I-ORG Health I-ORG NIH I-ORG R01 B-AWARD AI042310 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 61671458 B-AWARD 61701515 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Grant O No. O 2018JJ3608 B-AWARD and O the O Research O Project O of O the O National O University O of O Defense O Technology O Grant O No. O ZK170204 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2017M613367 B-AWARD This O research O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O 62061009 B-AWARD in O part O by O the O Fund O of O Key B-ORG Laboratory I-ORG of I-ORG Cognitive I-ORG Radio I-ORG and I-ORG Information I-ORG Processing I-ORG Ministry I-ORG of I-ORG Education I-ORG Guilin O University O of O Electronic O Technology O under O Grant O CRKL190110 B-AWARD and O in O part O by O the O Basic B-ORG Scientific I-ORG Research I-ORG Ability I-ORG Improvement I-ORG Project I-ORG for I-ORG Young I-ORG and I-ORG Middle-aged I-ORG Teachers I-ORG of I-ORG Universities I-ORG in I-ORG Guangxi I-ORG Province I-ORG 2020KY05029 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 82102230 B-AWARD and O 82072012 B-AWARD the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2018YFE0205000 B-AWARD and O the O 111 B-ORG Project I-ORG of I-ORG China I-ORG No. O B07014 B-AWARD L.C O was O a O recipient O of O the O joint O scholarship O of O UA O and O China B-ORG Scholarship I-ORG Council I-ORG CSC201506350012 O and O was O also O supported O by O a O Wine B-ORG Australia I-ORG supplementary O scholarship O AGW O Ph1512 O The O Australian B-ORG Research I-ORG Council I-ORG Training O Centre O for O Innovative O Wine O Production O www.ARCwinecentre.org.au O project O number O IC170100008 B-AWARD is O funded O by O the O Australian O Government O with O additional O support O from O Wine O Australia O and O industry O partners O The O University O of O Adelaide O is O the O member O of O the O Wine O Innovation O Cluster O This O work O was O supported O by O grants O from O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG 20ZR1446200 O Research B-ORG Foundation I-ORG of I-ORG Shanghai I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG 201940219 O Xinhua B-ORG Hospital I-ORG 18YJ02 O Shanghai B-ORG Key I-ORG Laboratory I-ORG of I-ORG Pediatric I-ORG Gastroenterology I-ORG and I-ORG Nutrition I-ORG 17DZ2272000 O and O Foundation B-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Health I-ORG Commission I-ORG Key O weak I-AWARD discipline I-AWARD construction I-AWARD project I-AWARD 2019ZB0101 O This O study O was O funded O by O grants O from O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2014A030312011 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31601917 O and O the O Guangdong B-ORG Sailing I-ORG Program I-ORG 2014YT02H042 O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31702187 O the O Key B-ORG Project I-ORG of I-ORG Shaanxi I-ORG Natural I-ORG Science I-ORG Basic I-ORG Research I-ORG Plan I-ORG 2022JZ-12 O the O Key B-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG Education I-ORG Department I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 22JY017 O the O Open B-ORG Project I-ORG of I-ORG the I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Silkworm I-ORG Genome I-ORG Biology I-ORG sklsgb-2019KF04 O and O the O Scientific B-ORG Research I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG University I-ORG of I-ORG Technology I-ORG SLGKYXM2202 O The O funding O for O the O STAMP O trial O was O provided O by O the O Joint B-ORG Global I-ORG Health I-ORG Trials I-ORG Scheme I-ORG of O the O UK O Department O of O Health O and O Social O Care O the O Department O for O International O Development O the O Global O Challenges O Research O Fund O the O Medical O Research O Council O and O Wellcome B-ORG Trust I-ORG MR/M007375/1 O AG-W O has O received O a O Royal B-ORG College I-ORG of I-ORG Physicians I-ORG London O JMGP B-AWARD Fellowship O ELC O has O received O a O Wellcome O Trust O Fellowship O WT200901/Z/16/Z O Funding O for O LAM-RCT O was O provided O by O the O European O Developing O Clinical O Trials O Partnership O the O South O African O Medical O Research O Council O and O the O South O African O National O Research O Foundation O for O the O TB O Neat O project O The O MSF O cohort O study O at O Homa O Bay O County O Hospital O Kenya O was O funded O by O Medecins O Sans O Frontières O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O partially O funded O by O the O Canadian B-ORG Institutes I-ORG for I-ORG Health I-ORG Research I-ORG under O Grant B-AWARD HIV/AIDS I-AWARD Operating I-AWARD Grant I-AWARD 2010 I-AWARD and I-AWARD 2012 O and O the O United B-ORG States I-ORG Agency I-ORG for I-ORG International I-ORG Development I-ORG under O Grant O 674-A-00-OIO-00034-00 B-AWARD Authors’ O time O was O supported O by O the O National B-ORG Institute I-ORG of I-ORG Child I-ORG Health I-ORG and I-ORG Human I-ORG Development I-ORG under O Grant O R01-HD077873 B-AWARD and O the O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health I-ORG under O Grant O F31-MH103078 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O a O grant O to O HW O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31770708 B-AWARD a O grant O to O JW O from O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2016YFD0600104 B-AWARD grants O to O HW O from O the O Science B-ORG Foundation I-ORG of I-ORG the I-ORG Beijing I-ORG Academy I-ORG of I-ORG Agriculture I-ORG and I-ORG Forestry I-ORG Sciences I-ORG Grant O No. O KJCX20170203 B-AWARD and O the O National O Natural O Science O Foundation O of O China O Grant O No. O 31270593 B-AWARD and O a O grant O to O YC O from O the O National B-ORG Key I-ORG Program I-ORG on I-ORG Transgenic I-ORG Research I-ORG of I-ORG China I-ORG Grant O No. O 2018ZX0802002 B-AWARD This O work O was O supported O by O research O grants O from O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Taiwan I-ORG to O C.-Y.T O 105-2320-B-002-054-MY3 O 102-2320-B-002-021-MY3 B-AWARD and O C.-J.J O 105-2320-B-010-016-MY3 O from O National B-ORG Institutes I-ORG of I-ORG Health O USA O R01GM065447 O to O T.-Y.C O and O from O the O Brain O Research O Center O National O Yang-Ming O University O for O The O Featured O Areas O Research O Center O Program O within O the O framework O of O the O Higher B-AWARD Education I-AWARD Sprout I-AWARD Project I-AWARD by O the O Ministry B-ORG of I-ORG Education I-ORG in O Taiwan O to O C.-J.J O This O work O was O supported O by O the O Yunnan B-ORG Province I-ORG Education I-ORG Department I-ORG Fund I-ORG Project I-ORG grant O No: O 2014Z053 B-AWARD the O Yunnan B-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG grant O No: O 2016NS126 B-AWARD and O the O Kunming B-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Personnel I-ORG Training I-ORG Project I-ORG grant O No: O sw-78 B-AWARD The O funding O bodies O have O the O role O in O the O design O of O the O study O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the O Youth B-ORG Foundation I-ORG of I-ORG Educational I-ORG Committee I-ORG of I-ORG Hebei I-ORG Province I-ORG grant O no. O QN2017123 B-AWARD Undergraduate B-ORG Training I-ORG Programs I-ORG for I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG of I-ORG North I-ORG China I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG grant O no. O X2016161 B-AWARD to O KZ, O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 31371282 B-AWARD to O XW, O National O Natural O Science O Foundation O of O China O grant O no. O 31501072 B-AWARD to O TL, O National B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG province I-ORG grant O no. O C2016209097 B-AWARD to O WG, O China-Hebei B-ORG 100 I-ORG Scholars I-ORG Supporting I-ORG Project I-ORG grant O no. O E2013100003 B-AWARD to O XW. O The O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81872255 O and O 62041101 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20200710 O the O Social B-ORG Devel-opment I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BE2022812 O the O Leading-edge B-ORG Technology I-ORG Programme I-ORG of I-ORG Jiangsu I-ORG Natural I-ORG Science I-ORG Foundation I-ORG BK20212021 O This O work O is O funded O by O Medicine B-ORG and I-ORG Engineering I-ORG Interdisciplinary I-ORG Research I-ORG Fund I-ORG of I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG No. O YG2020YQ06 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG No. O 2018YFC1705100 B-AWARD and O 2018YFC1705103 B-AWARD Science B-ORG and I-ORG Technology I-ORG Commission I-ORG Shanghai I-ORG Municipality I-ORG No. O 20JC1410204 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 71673187 B-AWARD This O research O was O funded O by O INSERM B-ORG grant O number O INSERM-2020-2024 B-AWARD CNRS B-ORG grant O number O CNRS-2020-2024 B-AWARD University B-ORG of I-ORG Paris-Cité O grant O number O UPC-2020-2024 B-AWARD Labex B-ORG Inflamex O grant O number O Inflamex-2020-2024 B-AWARD Vaincre B-ORG la I-ORG mucoviscidose I-ORG VLM O grant O number O VLM-2020-2022 B-AWARD and O The B-ORG Tunisian I-ORG DGRST O grant O number O DGRST-2020-2024 B-AWARD This O study O was O funded O by O the O Chinese B-ORG Academy I-ORG of I-ORG Engineering I-ORG 2020-KYGG-01-06 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 72042013 O and O Peking B-ORG University I-ORG Health I-ORG Science I-ORG Center I-ORG BMU2020HKYZX001 O This O work O was O supported O by O Secretaría O de O Ciencia O y O Tecnología O Universidad O Nacional O de O Córdoba O Grant O number O 05/C642 O Agencia B-ORG Nacional I-ORG de I-ORG Promoción I-ORG Científica I-ORG y I-ORG Tecnológica I-ORG ANPCyT O Fondo O para O la O Investigación O Científica O y O Tecnológica O PICT O 2013-2885 O Consejo B-ORG Nacional I-ORG de I-ORG Investigaciones I-ORG Científicas I-ORG y I-ORG Técnicas I-ORG CONICET O PIP O 11220120100620 O and O by O Ministerio B-ORG de I-ORG Ciencia I-ORG y I-ORG Tecnología I-ORG Gobierno I-ORG de I-ORG la I-ORG Provincia I-ORG de I-ORG Córdoba I-ORG 1143/10 O This O study O was O funded O by O the O following O National B-ORG Nature I-ORG Science I-ORG Foundations I-ORG of I-ORG China I-ORG NSFC O No. O 12175153 B-AWARD No. O 12075156 B-AWARD Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation O 2021A1515010048 B-AWARD Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Program O JCYJ20210324095007020 B-AWARD JCYJ20200109105201936 B-AWARD 20200803105052010 B-AWARD This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 81500490 B-AWARD BRL O 81770635 B-AWARD LHH O 81470883 B-AWARD LHH O and O 81770632(LX B-AWARD and O Three B-ORG engineering I-ORG training I-ORG funds I-ORG in I-ORG Shenzhen I-ORG Grant O No. O SYJY201713(LSW B-AWARD in O data O acquisition O and O manuscript O drafting O Shanghai B-ORG Rising-Star I-ORG Program I-ORG Grant O No. O 17QA1405500 B-AWARD LHH O Shanghai B-ORG Outstanding I-ORG Youth I-ORG Doctor I-ORG Training I-ORG Program I-ORG Grant O No. O AB83030002015034 B-AWARD LHH O and O Shanghai B-ORG Youth I-ORG Top-notch I-ORG Talent I-ORG Program I-ORG Grant O No. O HZW2016FZ67 B-AWARD LHH O in O conception O design O data O interpretation O and O manuscript O revise O This O work O was O supported O by O the O Sub-Project O of O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Plan I-ORG of I-ORG the I-ORG Twelfth I-ORG Five-Year I-ORG Plan I-ORG in I-ORG China I-ORG 2015BAD04B03 O and O 2015BAD04B01 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG International I-ORG Center I-ORG for I-ORG Bamboo I-ORG and I-ORG Rattan I-ORG 1632017018 O and O the O Science B-ORG Technology I-ORG and I-ORG Innovation I-ORG Committee I-ORG of I-ORG Shenzhen I-ORG Municipality I-ORG JCYJ20160331190123578 O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2019YFB1309500 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 91948202 O and O 51822502 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG HIT.BRETIV.201903 O and O the O Fundamental O Research O Funds O for O the O Central O Universities O FRFCU9803500621 O This O research O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 41571524 B-AWARD the O National B-ORG Social I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 15BGL041 B-AWARD the O Social B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG No. O 15YBA014 B-AWARD and O the O Collaborative B-ORG Innovation I-ORG Center I-ORG for I-ORG the I-ORG Development I-ORG of I-ORG Modern I-ORG Services I-ORG and I-ORG New I-ORG Urbanization I-ORG in I-ORG Hunan I-ORG Province I-ORG No. O CIC1502 B-AWARD This O research O was O funded O by O National O Key O R&D O Program O of O China O 2018YFD0901103 O NSFC B-ORG 31872540 O 41706170 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG LY18C190004 O LY19H030001 I-AWARD LQ20D060001 O Medical O Science O and O Technology O of O Zhejiang O Province O 2018KY726 O 2018KY710 O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-50 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Ningbo I-ORG 2019A610326 O and O Ningbo O Programs O for O Science O and O Technology O Development O 2019C50095,2017C110026 O K.C O Wong O Magna O Fund O in O Ningbo O University O This O study O was O supported O in O part O by O grants O from O the O Programs B-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81572372 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG ‘Major I-ORG Chronic I-ORG Non-Infectious I-ORG Disease I-ORG Research’ I-ORG of I-ORG China I-ORG No. O 2016YFC1303202 B-AWARD and O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG ‘Precision I-ORG Medicine I-ORG Research’ I-ORG of I-ORG China I-ORG No. O 2017YFC0908304 B-AWARD The O work O was O financially O supported O by O grants O from O the10.13039/501100001809National O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China(91751207 O 31770093 B-AWARD the10.13039/501100012166National O Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China(2016YFA0601103 O and O the10.13039/501100007129Natural O Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG China(ZR2016CM03 O ZR2017ZB0210 B-AWARD This O work O was O funded O by O the O National O Institute O of O Health O Common O Themes O in O Reproductive O Diversity O program O for O a O Predoctoral O Fellowship O to O SPS O grant O number O 2 B-AWARD T32 I-AWARD HD049336-11A1 O the O National B-ORG Science I-ORG Foundation I-ORG IOS-1257474 O to O E.D.K O a O FRSP B-AWARD grant O from O Indiana B-ORG University I-ORG to O E.D.K O and O by O an O Institutional O Development O Award O IDeA O from O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG of O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG under O grant O number O P20GM103443 B-AWARD through O the O South O Dakota O Biomedical O Research O Infrastructure O Network O SD O BRIN O core O facilities O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O F.J.P O acknowledges O financial O support O from O ANID B-ORG Fondecyt O Iniciación O en O Investigación O 2020 O grant O no. O 11200032 B-AWARD ANID O Fondecyt O grant O no. O 1210312 B-AWARD “Millennium B-ORG Nucleus I-ORG in I-ORG NanoBioPhysics” I-ORG project O NNBP B-AWARD NCN2021_021 O N.M.M O acknowledges O support O from O AFOSR B-ORG FA2386-21-1-4081 O FA9550-19-1-0272 B-AWARD FA9550-23-1-0034 B-AWARD and O ARO B-ORG W911NF2210247 O W911NF2010013 B-AWARD F.A.-A O acknowledges O financial O support O from O ANID B-ORG Subvención I-ORG a I-ORG la I-ORG Instalación I-ORG en I-ORG la I-ORG Academia I-ORG SA77210018 B-AWARD and O ANID B-ORG Proyecto I-ORG Basal I-ORG AFB I-ORG 220001 B-AWARD P.V O acknowledges O support O from O ANID O Fondecyt O grant O no. O 1210312 O and O ANID O PIA/Basal O grant O no. O AFB O 220001 O The O study O was O supported O by O theNational O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China(31370707,31000322 O the O Basic O Research O Fund O ofCAF(CAFYBB2007043,200714 O and O the O Huimin O Project O of O theMinistry O of I-ORG Science I-ORG and I-ORG Technology(2012GS610203 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O contract O No. O 31471202 B-AWARD Lei O Zhang O and O No. O 81670822 B-AWARD Ye O Wang O the O Shandong B-ORG Provincial I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG under O contract O No. O 2016YYSP009 B-AWARD Lei O Zhang O Weihai B-ORG Technique I-ORG Extension I-ORG Project I-ORG under O contract O No. O 2016GNS023 B-AWARD Lei O Zhang O and O the O Qingdao B-ORG Key I-ORG Research I-ORG project I-ORG No. O 17-3-3-10-nsh B-AWARD Chunling O Zhang O Lei O Zhang O is O also O supported O by O the O Taishan B-ORG Scholars I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG No. O tshw20120206 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2021YFB3802100 O 2021YFB3802105 B-AWARD Major B-ORG Project I-ORG of I-ORG Sichuan I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG 2022ZDZX0029 O the O International B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Cooperation I-ORG Project I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2021YFH0131 O National O Natural O Science O Foundation O of O China O 52002256 O the O Science O and O Technology O Cooperation O Program O of O Sichuan O University O and O Panzhihua O City O 2021 O Sichuan O University O ‘Zero O to O one’ O Innovation O Research O Project O 0082604151276 O This O work O was O supported O by O Portuguese O funds O through O FCT O Fundação O para I-ORG a I-ORG Ciência I-ORG e I-ORG a I-ORG Tecnologia O I.P O in O the O framework O of O the O project O PTDC/BTM-MAT/4156/2021 B-AWARD D.M O acknowledges O FCT O for O her O Ph.D O scholarship O UI/BD/150831/2021 O V.L O for O her O Assistant O Researcher O contract O under O the O “Concurso O Estímulo I-ORG ao I-ORG Emprego I-ORG Científico I-ORG Individual—4.ª I-ORG Edição” O 2021.00472.CEECIND O and O S.D.S O for O her O contract O under O the O Norma B-ORG Transitória–DL57/2016/CP/CP1360/CT0013 O Funded O by O TN: O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health I-ORG Grant O No. O R25 B-AWARD MH067127)https://www.nimh.nih.gov/index.shtml O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O the O manuscript O DC: O National B-ORG Institute I-ORG on I-ORG Drug I-ORG Abuse I-ORG Grant O No. O 1 O R03DA041891 B-AWARD 01A1)https://www.drugabuse.gov O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O the O manuscript.https://www.nimhd.nih.gov/programs/extramural/loan-repayment.htmlNational O Institute I-ORG on I-ORG Minority I-ORG Health I-ORG and I-ORG Health I-ORG Disparities I-ORG Loan O Repayment O Program O Grant O No. O L60 B-AWARD MD006269 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O the O manuscript O Peter O E. O Mortimer O thanks O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG and I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG for O financial O support O under O the O following O grant O 41761144055 B-AWARD Dhanushka O Wanasinghe O would O like O to O thank O CAS B-ORG President’s I-ORG International I-ORG Fellowship I-ORG Initiative I-ORG PIFI O for O funding O his O postdoctoral O research O number O 2019PC0008 B-AWARD and O the O 64th B-ORG batch I-ORG of I-ORG China I-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG grant O no O Y913083271 B-AWARD Nalin O Wijayawardene O thanks O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O NSFC O 31950410558 B-AWARD This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 81770832 B-AWARD 31372276 B-AWARD the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG grant O no. O 2015CB943100 B-AWARD the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG grant O no. O 2016ZX08006-001 B-AWARD 2016ZX08010-003 B-AWARD the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Animal I-ORG Nutrition I-ORG grant O no. O 2004DA125184G1602 B-AWARD and O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG grant O no. O ASTIP-IAS05 B-AWARD and O ASTIP-IAS-TS-4 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the B-ORG Special I-ORG Program I-ORG for I-ORG Diagnosis I-ORG and I-ORG Treatment I-ORG Technology I-ORG of I-ORG Clinical I-ORG Key I-ORG Diseases I-ORG in I-ORG Suzhou I-ORG LCZX202001 O Medical B-ORG and I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG in I-ORG Suzhou I-ORG SKY2022003 O Jiangsu B-ORG Provincial I-ORG Key I-ORG Medical I-ORG Discipline I-ORG JSDW202242 O This O work O was O supported O by O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG Grant O number O 2014BAI06B02 B-AWARD the O Chinese B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O numbers O 81170730 B-AWARD 81570709 B-AWARD 81500605 B-AWARD the O Foundation B-ORG of I-ORG Key I-ORG Laboratory I-ORG in I-ORG Department I-ORG of I-ORG Education I-ORG of I-ORG Liaoning I-ORG Province I-ORG Government I-ORG in I-ORG China I-ORG Grant O number O LZ2014035 B-AWARD the O Liaoning B-ORG Science I-ORG Public I-ORG Research I-ORG Funds I-ORG Grant O number O 2014001001/GY2014-A-001 B-AWARD the O Key B-ORG Platform I-ORG Foundation I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG for I-ORG the I-ORG Universities I-ORG in I-ORG Liaoning I-ORG Province I-ORG Grant O number O 16010 B-AWARD the O Shenyang B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG Grant O number O 17-230-9-02 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG of O China O No. O 31370185 B-AWARD the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of O China O No. O 2011CB504800 B-AWARD the O National B-ORG Infrastructure I-ORG of I-ORG Natural I-ORG Resources I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG No.2011-572 O to O Prof O C O Zheng O and O the O National O Science O and O Technology O Infrastructure O Grant O NSTI-CR15 O and O NSTI-CR16 O and O the O Fundamental O Research O Funds O for O the O Central O Universities O 2042018kf0241 O to O Dr. O Chao O Shen O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O partially O financed O by O Secretaria B-ORG de I-ORG Investigación I-ORG y I-ORG Posgrado I-ORG projects O 20120971 B-AWARD 20121594 B-AWARD 20130059 B-AWARD 20130089 B-AWARD 20140781 B-AWARD 20140465 B-AWARD 20150998 B-AWARD 20150117 B-AWARD CONACyT B-ORG 108230 B-AWARD and O institutional O fund O CONACyT B-ORG Fronteras I-ORG de I-ORG la I-ORG Ciencia I-ORG 292/2016 B-AWARD José O F O Domínguez-Contreras O benefited O from O Consejo B-ORG Nacional I-ORG de I-ORG Ciencia I-ORG y I-ORG Tecnología I-ORG doctoral I-ORG 328943 O and O postdoctoral B-ORG 291053 O estancias O posdoctorales O nacionales O 2016-1 O scholarships O This O work O was O partially O supported O via O the O PANGAS O Science O Coordination O by O the O David B-ORG and I-ORG Lucile I-ORG Packard I-ORG Foundation I-ORG grants O 2013-39400 B-AWARD 2015-62798 B-AWARD There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O research O for O this O paper O is O funded O by O the O HICoE-MoHE B-ORG Grant I-ORG Air-Ocean-Interaction I-ORG IOES-2014 O IOES-2014F B-AWARD University B-ORG of I-ORG Malaya I-ORG Research I-ORG Grant I-ORG UMRG I-ORG RG206-13SUS O Knowledge B-ORG Management I-ORG Grant I-ORG RU009K-2015 O RU009E-2015 B-AWARD Fundamental B-ORG Research I-ORG Grant I-ORG Scheme I-ORG FRGS I-ORG FP018-2012A O and O the O University B-ORG of I-ORG Malaya I-ORG Postgraduate I-ORG Research I-ORG Fund I-ORG PPP I-ORG PO029-2014A O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31600223 B-AWARD Hong B-ORG Kong I-ORG Scholars I-ORG Program I-ORG XJ2017017 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No. O GK201803041 B-AWARD and O GK201901004 B-AWARD State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Cotton I-ORG Biology I-ORG Open I-ORG Fund I-ORG Grant O No. O CB2018A03 B-AWARD National B-ORG Undergraduate I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Training I-ORG Program I-ORG Grant O No. O cx2018143 B-AWARD Natural O Science O Basic O Research O Plan O in O Shaanxi O Province O of O China O Grant O No. O 2018JZ3006 O and O 2019JM-491 O Shaanxi O Youth O Entrusted O Talents O Program O Grant O No. O 20190205 O Shaanxi O Postdoctoral O Project O Grant O No. O 2018BSHYDZZ76 O and O Diligent B-ORG Research I-ORG and I-ORG Innovation I-ORG Fund I-ORG Project I-ORG Grant O No. O KY2018YB003 B-AWARD The O funding O bodies O provided O the O financial O support O to O the O research O projects O but O didn’t O involved O in O study O design O data O collection O analysis O or O preparation O of O the O manuscript O We O gratefully O acknowledge O the O financial O support O of O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 21466037 B-AWARD the O science O and O technology O major O program O of O the O Yunnan B-ORG Education I-ORG Bureau I-ORG ZD2014009 O and O the O Traditional B-ORG Chinese I-ORG Medicine I-ORG Joint I-ORG Project I-ORG of I-ORG Yunnan I-ORG applied O basic O research O U2016XX O This O work O was O funded O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jilin I-ORG Province I-ORG of I-ORG China I-ORG No. O 20170101003JC B-AWARD the B-ORG Strategic I-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG No. O XDA16010403 B-AWARD and O Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG No. O 1610342016003 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O the O preparation O of O the O manuscript O This O work O was O supported O by O the O Technology B-ORG and I-ORG Demonstration I-ORG of I-ORG Ecological I-ORG Protection I-ORG and I-ORG Exploitation I-ORG and I-ORG Utilization I-ORG of I-ORG Biological I-ORG Resources I-ORG in I-ORG Northeast I-ORG Forest I-ORG Region I-ORG 2016YFC0500306 O the O Construction B-ORG of I-ORG China I-ORG Botanical I-ORG Garden I-ORG Alliance I-ORG Key I-ORG Project I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG KFJ-3W-No1 O the O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG Science I-ORG and I-ORG Technology I-ORG Resources I-ORG Popularization I-ORG Capacity I-ORG Building I-ORG F16-191-5-00 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O U.C O has O been O supported O by O SZN O OU O PhD O fellowship O and O by O short-term O fellowships O from O EMBO B-ORG 7534 O and O The O Company O of O Biologists O DEVTF-171108 O P.O O has O been O supported O by O SZN O OU O PhD O fellowship O A.S O is O supported O by O NIH B-ORG grant O HD084814 B-AWARD and O C.J.J O is O supported O by O an O NSF B-ORG Graduate B-AWARD Research I-AWARD Fellowship I-AWARD This O research O was O funded O by O the O National B-ORG Science I-ORG Foundation’s O Division O of O Materials O Science O Biomaterials O Program O DMR-BMAT O under O grant O number O 2100978 B-AWARD The O authors O also O acknowledge O the O support O of O the O National B-ORG Institute I-ORG on I-ORG Minority I-ORG Health I-ORG and I-ORG Health I-ORG Disparities I-ORG through O grant O number O 5U54MD013376 B-AWARD and O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG through O grant O number O 5UL1GM118973 B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31760567 O 31460505 B-AWARD the O science O and O technology O research O project O of O the O Education B-ORG Department I-ORG of I-ORG Jiangxi I-ORG Province I-ORG Gjj150382 O and O the O key O projects O of O Weinan B-ORG Normal I-ORG University I-ORG 16ZRRC01 O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31201934 O the O Zhejiang B-ORG Provincial I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG programs I-ORG 2019C02052-2 O the O Projects O of O Zhejiang B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Plans I-ORG 2016C02054-7 O and O the O Young O Talent O Training O Project O of O Zhejiang B-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG 10102000617CF0101G/003/003 O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O developed O within O the O scope O of O the O CICS-UBI O projects O UIDB/00709/2020 B-AWARD and O UIDP/00709/2020 B-AWARD financed O by O national O funds O through O the B-ORG Portuguese I-ORG Foundation I-ORG for I-ORG Science I-ORG and I-ORG Technology/MCTES O This O work O was O also O supported O by O national O funds O from O FCT—Fundação B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG a I-ORG Tecnologia O I.P O in O the O scope O of O the O project O UIDP/04378/2020 B-AWARD and O UIDB/04378/2020 B-AWARD of O the O Research O Unit O on O Applied O Molecular O Biosciences—UCIBIO O and O the O project O LA/P/0140/2020 B-AWARD of O the B-ORG Associate I-ORG Laboratory I-ORG Institute I-ORG for I-ORG Health I-ORG and I-ORG Bioeconomy—i4HB O Diana O Gomes O also O acknowledges O the O doctoral O fellowship O from O FCT O ref O 2020.06792.BD B-AWARD Diana O Costa O acknowledges O FCT O her O Assistant O Researcher O Contract O 2021.03946.CEECIND B-AWARD The O microscopy O facility O used O in O the O development O of O this O work O is O part O of O the O PPBI-Portuguese B-ORG Platform I-ORG of I-ORG BioImaging I-ORG and O is O partially O supported O by O the O Project O POCI-01-0145-FEDER-022122 B-AWARD This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0101906 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31401729 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG 2016JJ4051 O This O work O was O sponsored O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG project O 31822058 O 31672656 O 31872602 O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG 2019A1515011441 O and O The B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Fund I-ORG Macau I-ORG SAR I-ORG 0058/2018/A2 O JR O and O KAL O were O supported O by O The O Wellcome B-ORG Trust I-ORG https://wellcome.ac.uk O and O The O Royal O Society O https://royalsociety.org O grant O no. O 107652/Z/15/Z B-AWARD KAL O This O study O was O supported O in O part O by O the O Division O of O Intramural O Research O National O Institute O of O Allergy O and O Infectious O Disease O National B-ORG Institutes I-ORG of I-ORG Health O https://www.nih.gov O and O by O a O cooperative O agreement O W81XWH-07-2-0067 O between O the O Henry O M. O Jackson O Foundation O for O the O Advancement O of O Military O Medicine O Inc O and O the O U.S O Department O of O Defense O DOD O CF O was O supported O by O the O Bridging O the O Evolution O and O Epidemiology O of O HIV O in O Europe O BEEHIVE O study O via O a O European B-ORG Research I-ORG Council I-ORG Advanced O Grant O grant O number O PBDR-339251 B-AWARD https://erc.europa.eu O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O LY14H060001 B-AWARD Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Huzhou I-ORG City I-ORG grant O number O 2016GY26 B-AWARD Zhejiang B-ORG Provincial I-ORG Technological I-ORG Research I-ORG Project I-ORG for I-ORG Public I-ORG Welfare I-ORG grant O number O 2017C33227 B-AWARD This O research O was O funded O by O the O Key B-ORG R&D I-ORG Program I-ORG of I-ORG Shandong I-ORG province I-ORG No. O 2019JZZY011104 B-AWARD and O College B-ORG Youth I-ORG Innovation I-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Programme I-ORG of I-ORG Shandong I-ORG province I-ORG No. O 2020KJK003 B-AWARD and O Key B-ORG support I-ORG projects I-ORG inheritance I-ORG and I-ORG development I-ORG of I-ORG traditional I-ORG Chinese I-ORG Medicine I-ORG of I-ORG the I-ORG State I-ORG Administration I-ORG of I-ORG traditional I-ORG Chinese I-ORG medicine I-ORG No. O 2021242 B-AWARD and O the B-ORG Scientific I-ORG Foundation I-ORG of I-ORG Binzhou I-ORG Medical I-ORG University I-ORG BY2021KYQD26 O This O study O was O financially O supported O by O Key O Laboratory O of O Medical O Antibacterial O Materials O of O Shandong O Province O and O Yantai O Medical O Antibacterial O Material O Innovation O Service O Platform O This O work O was O supported O by O the O Beijing B-ORG Nova I-ORG Program I-ORG Z181100006218116 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC1200502 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31970178 O and O the O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 5204039 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG 2014J4100133 O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2013B021800147 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG for I-ORG Youth I-ORG of I-ORG China I-ORG 81101451 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O RAK O is O supported O by O the O Sir O HenryWellcome O Trust(grant O number O 107392/Z/15/Z B-AWARD and O the O UKMedical O Research I-ORG Council I-ORG Programme(MC-A060-5PR61 O The O NSPN O cohort O was O supported O by O a O strategic O award O by O the O Wellcome O Trust O to O theUniversity O of I-ORG Cambridge I-ORG and I-ORG University I-ORG College I-ORG London(095844/Z/11/Z O This O project O has O received O funding O from O theEuropean O Union’s I-ORG Horizon I-ORG 2020research O and O innovation O programme O under O grant O agreement O No O 732592 B-AWARD This O work O was O funded O by O the O Faculty B-ORG of I-ORG Medicine I-ORG Chiang I-ORG Mai I-ORG University I-ORG Grant O no. O 055-2564 B-AWARD the O Post-Doctoral B-ORG Fellowship I-ORG Program I-ORG Chiang I-ORG Mai I-ORG University I-ORG Grant O no. O 9/2022 B-AWARD and O the O Royal B-ORG Golden I-ORG Jubilee I-ORG Scholarship I-ORG PhD I-ORG Program I-ORG RGJ O Grant O No. O PHD/0172/2558 B-AWARD This O research O was O supported O by O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2014CB138400 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31400136 O the B-ORG Key I-ORG Project I-ORG of I-ORG the I-ORG Fujian I-ORG Province I-ORG Education I-ORG Department I-ORG JK2014011 O and O the O FAFU B-ORG Foundation I-ORG for I-ORG Outstanding I-ORG Youth I-ORG XJQ201507 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31301368 O the B-ORG 863 I-ORG Project I-ORG of I-ORG China I-ORG 2013AA102601 O and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0101400 O This O work O was O supported O by O the O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG Grant O No. O 2016YFD0500606 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31772776 B-AWARD Key-Area B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG Grant O No. O 2019B020217002 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Major B-ORG State I-ORG Basic I-ORG Research I-ORG Development I-ORG Program I-ORG of O China O No. O 2012CB114500 B-AWARD National O “Twelfth O Five-year” O Plan O for O Science B-ORG I-ORG Technology I-ORG Support I-ORG Development I-ORG Program I-ORG of O China O No. O 2012BAD01B0201 B-AWARD and O the O Bamboo/Tree B-ORG Breeding I-ORG Project I-ORG of O Zhejiang O Province O “Twelfth O Five-Year” O Plan O No. O 2012C12908-11 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG 2030 I-ORG 2022ZD0400801 O Chongqing B-ORG Agricultural I-ORG and I-ORG Rural I-ORG Committee I-ORG Project I-ORG cqnyncw-kqlhtxm O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31830067 O and O 32201741 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Chongqing I-ORG CSTB2022NSCQ-LZX0034 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82273034 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2022MC035 O and O Shandong B-ORG Youth I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Team I-ORG 2022KJ298 O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81301203 O 81471627 B-AWARD and O 81200919 B-AWARD Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG 17411953700 O Specialized B-ORG Research I-ORG Fund I-ORG for I-ORG the I-ORG Doctoral I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG of I-ORG China I-ORG 20130071130011 O and O Shanghai B-ORG Health I-ORG System I-ORG Important I-ORG Disease I-ORG Joint I-ORG Research I-ORG Project I-ORG 2013ZYJB009 O This O work O was O supported O by O FEDER/Ministerio O de O Ciencia O Innovación O y O Universidades–Agencia O Estatal O de O Investigación O SAF2017-87349-R O and O ISCIII B-ORG PIE14/00034 O the O Catalan B-ORG government I-ORG 2017 O SGR I-AWARD 1604 O Fundació O la O Marató O de O TV3 O Grant O 20152031 O and O FWO B-ORG SBO-140028 O to O FC. O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 31201586 B-AWARD Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangdong I-ORG China I-ORG grant O no. O 2014A020208138 B-AWARD and O 2015A020208018 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG grant O no. O 2016A030307016 B-AWARD National B-ORG Undergraduate I-ORG Training I-ORG Programs I-ORG for I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG grant O no.201510579240 O and O 201510579300 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Lingnan I-ORG Normal I-ORG University I-ORG grant O no. O LZL1507 B-AWARD All O these O funding O play O roles O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O grants O from O the O National B-ORG Science I-ORG Fund I-ORG of I-ORG China I-ORG 21803026 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20180854 O the O Hong B-ORG Kong I-ORG Research I-ORG Grants I-ORG Council I-ORG GRF O 17302419 O The O University O of O Hong O Kong O Development O Fund O 2013–2014 O project O “New O Ultrafast O Spectroscopy O Experiments O for O Shared O Facilities” O Major O Program O of O Guangdong O Basic O and O Applied O Research O 2019B030302009 O and O the O University O Project O of O Introduction O and O Cultivation O of O Leading O Talents O Grant O No. O gxfxZD2016044 O The O authors O acknowledge O the O funding O received O from O the O European B-ORG Research I-ORG Council I-ORG under O the O European O Union’s O Seventh O Framework O Programme O FP/2007-2013)/ERC O Grant O Agreement O No. O 306622 B-AWARD ERC O Starting O Grant O “Multi-field O and O Multi-scale O Computational O Approach O to O Design O and O Durability O of O PhotoVoltaic O Modules”—CA2PVM O JR O acknowledges O the O support O of O the O projects O funded O by O the O Spanish B-ORG Ministry I-ORG of O Economy O and O Competitiveness/FEDER O Projects O MAT2015-71036-P B-AWARD and O MAT2015-71309-P B-AWARD and O the O Andalusian B-ORG Government I-ORG Projects O of O Excellence O Nos O TEP-7093 B-AWARD and O P12-TEP-1050 B-AWARD This O research O was O funded O by O the O Fundação B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG Tecnologia/Ministério I-ORG da I-ORG Ciência I-ORG Tecnologia I-ORG e I-ORG Ensino I-ORG Superior I-ORG FCT/MCTES O Portugal O grant O PTDC/BBB-BMD/4497/2014 B-AWARD to O A.B O through O national O funds O to O iNOVA4Health B-ORG UIDB/04462/2020 O and O UIDP/04462/2020 B-AWARD and O the O Associate B-ORG Laboratory I-ORG LS4FUTURE I-ORG LA/P/0087/2020 O This O work O was O supported O by O grants O from O the B-ORG Anhui I-ORG Provincial I-ORG Laboratory I-ORG of I-ORG Applied I-ORG Basis I-ORG and I-ORG Development I-ORG of I-ORG Internal I-ORG Medicine I-ORG of I-ORG Modern I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG 2016080503B041 O the O 12th B-ORG batch I-ORG of I-ORG ‘115’ I-ORG Innovation I-ORG team I-ORG of I-ORG Anhui I-ORG Province I-ORG Anhui O Talent I-AWARD Office I-AWARD 2019 I-AWARD No. I-AWARD 1), O the O Anhui B-ORG Famous I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG Liu I-ORG Jian I-ORG Studio I-ORG Construction I-ORG Project I-ORG [2018 O No. I-AWARD 11 O the O Anhui B-ORG Province I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG Leading I-ORG Talent I-ORG Project I-ORG [2018 O No. I-AWARD 23 O This O work O was O supported O by O Taipei B-ORG Veterans I-ORG General I-ORG Hospital I-ORG V101E1-013 O V102C-155 B-AWARD V102E1-006 B-AWARD and O V103C-151 B-AWARD to O JW O Chen O Taiwan’s O National B-ORG Science I-ORG Council I-ORG NSC O 101-2314-B-010-058-MY3 I-AWARD to O JW O Chen O and O the B-ORG UST-UCSD I-ORG International I-ORG Center I-ORG of I-ORG Excellence I-ORG in I-ORG Advanced I-ORG Bio-engineering I-ORG sponsored I-ORG by I-ORG the I-ORG Taiwan I-ORG National I-ORG Science I-ORG Council I-ORG I-RiCE I-ORG Program I-ORG NSC-99-2911-I-009-101 O to O JW O Chen O The O funding O body O has O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the B-ORG key I-ORG research I-ORG and I-ORG development I-ORG program I-ORG of I-ORG Ningxia I-ORG Grant O No. O 2016BZ0602 B-AWARD National B-ORG Twelfth I-ORG Five-Year I-ORG Plan I-ORG for I-ORG Science I-ORG I-ORG Technology I-ORG Support I-ORG Key I-ORG Technology I-ORG Research I-ORG and I-ORG Industry I-ORG Demonstration I-ORG of I-ORG High I-ORG Quality I-ORG Fruit I-ORG Wine I-ORG Grant O No. O 2012BAD31B07 B-AWARD and O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG for I-ORG Grape I-ORG Grant O No. O CARS-30-zp-9 B-AWARD The O authors O also O sincerely O thanked O Dr. O Zheng O Li O from O the O Food O Science O and O Human O Nutrition O Department O at O the O University O of O Florida O for O the O paper O revision O discussion O suggestion O and O paper O editing O This O study O was O primarily O sponsored O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81903415 B-AWARD the O Postdoctoral O Research O Foundation O of O Sichuan B-ORG University I-ORG grant O number O 2018SCU12014 B-AWARD and O Key O R&D O Project O of O Sichuan B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG grant O number O 2020YFS0215 B-AWARD Yue O Ma O was O supported O by O the O National O Natural O Science O Foundation O of O China O grant O number O 81803332 B-AWARD Xing O Zhao O was O supported O by O the O National O Natural O Science O Foundation O of O China O grant O number O 81773548 B-AWARD The O funding O body O has O not O been O involved O with O the O study O design O nor O the O conduct O of O the O study O This O research O was O funded O by O the O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 3184056 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51805023 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 1175279 B-AWARD and O Fundamental O Research O Funds O for O the O Central O Universities O No. O FRF-TP-17-057A1 O Hospital B-ORG Militar I-ORG Central I-ORG 2016-099 O the O Government B-ORG Institute I-ORG of I-ORG Science I-ORG Technology I-ORG and I-ORG Innovation I-ORG Francisco I-ORG Jose I-ORG de I-ORG Caldas—COLCIENCIAS I-ORG Grant O 130865740792 B-AWARD and O Universidad B-ORG El I-ORG Bosque I-ORG UB2016 O This O study O was O funded O by O the O National B-ORG Science I-ORG Fund I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG 81025019 O and O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2012CB517603 O for O Prof O Junfeng O Zhang O the O Nanjing B-ORG University I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Pharmaceutical I-ORG Biotechnology I-ORG Independent I-ORG Research I-ORG Grant I-ORG ZZYJ-SN-201405 O and O the O Project B-ORG of I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20161478 O for O Dr. O Zhi O Ding O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O is O supported O by O the O University B-ORG Nature I-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG Anhui I-ORG Province I-ORG grant O number O KJ2017A832 B-AWARD and O Program B-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG of I-ORG Anhui I-ORG Province I-ORG grant O number O 1704a0802158 B-AWARD and O the O Natural B-ORG science I-ORG foundation I-ORG project I-ORG of I-ORG Anhui I-ORG Province I-ORG grant O number O 1408085QH174 B-AWARD They O fully O financed O the O costs O of O the O study O and O contributed O to O the O design O of O the O study O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O grants O from O the O Gordon B-ORG and I-ORG Betty I-ORG Moore I-ORG Foundation I-ORG through O Grant O GBMF2550.06 B-AWARD to O S.C.G O and O from O the O National B-ORG Science I-ORG Foundation I-ORG Plant I-ORG Genome I-ORG Research I-ORG Program I-ORG IOS-1546218 O the O Zegar B-ORG Family I-ORG Foundation I-ORG A16-0051 O and O the O NYU B-ORG Abu I-ORG Dhabi I-ORG Research I-ORG Institute I-ORG G1205 O to O M.D.P O The O funding O body O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O Electron O microscopy O was O funded O by O the O Molecular O Foundry O which O is O supported O by O the B-ORG Office I-ORG of I-ORG Science O the O Office O of O Basic O Energy O Sciences O the O U.S O Department O of O Energy O under O Contract O No. O DE-AC02-05CH11231 B-AWARD The O inclusion O of O GaN O materials O was O supported O by O DTRA B-ORG contract I-ORG HDTRA1-17-1-0032 B-AWARD The O Center O for O Visualizing O Catalytic O Processes O is O sponsored O by O the O Danish B-ORG National I-ORG Research I-ORG Foundation I-ORG DNRF146 O The O research O was O supported O by O Basic B-ORG Research I-ORG on I-ORG the I-ORG Frontier I-ORG and I-ORG Application I-ORG of I-ORG Chongqing I-ORG City I-ORG under O grant O cstc2015jcyjA40006 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61702059 B-AWARD Postgraduate O Educational O Grant O of O Chongqing O City O yjg20163062 O Educational O Grant O of O Chongqing O University O 2016Y25 O Research O Fund O of O Guangxi O Key O Lab O of O Multisource O Information O Mining O O Security O MIMS18-03 O and O Project O No. O 2018CDGFCH0020 B-AWARD supported O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG This O work O was O supported O by O grant O 220020240 B-AWARD from O the O James B-ORG S. I-ORG McDonnell I-ORG Foundation O 21st O Century O Science O Scholar O in O Understanding O Human O Cognition O Program O and O grant O ES/N01846X/1 B-AWARD from O the O Economic B-ORG and I-ORG Social I-ORG Research I-ORG Council I-ORG of O the O United O Kingdom O This O project O has O received O funding O from O the O European B-ORG Research I-ORG Council I-ORG ERC O under O the O European O Union’s O Horizon O 2020 O research O and O innovation O programme O grant O agreement O No. O 820185 B-AWARD All O three O were O granted O to O MN. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Seehttps://www.jsmf.org/,https://esrc.ukri.org/andhttps://ec.europa.eu O This O project O was O funded O by O the O grants O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC I-ORG No: O 31201996 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017A030303075 O and O Science B-ORG and I-ORG technology I-ORG innovation I-ORG project I-ORG for I-ORG undergraduate I-ORG of I-ORG Guangdong I-ORG Ocean I-ORG University I-ORG qhjh2017kj11 O This O work O was O supported O by O Eli B-ORG Lilly I-ORG and I-ORG Company I-ORG AbbVie I-ORG GK, I-ORG Sun I-ORG Pharma I-ORG Maruho I-ORG Takagi I-ORG Dermatology I-ORG Foundation I-ORG JSPS I-ORG KAKENHI I-ORG Grant O Number O JP22H04922 B-AWARD AdAMS O and O MEXT B-ORG Promotion I-ORG of I-ORG Distinctive I-ORG Joint I-ORG Research I-ORG Center I-ORG Program I-ORG Grant O Number O FY2021-2023 B-AWARD JPMXP0621467949 O and O KAKENHI O Grand O Number O 22K08379 B-AWARD This O research O was O partially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O nos O 31471847 B-AWARD and O 31572092 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Service I-ORG Network I-ORG Initiative I-ORG of I-ORG Chinese I-ORG Academy I-ORG grant O no. O KFJ-EW-STS-076 B-AWARD and O the O Crop B-ORG Germplasm I-ORG Conservation I-ORG Project I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 2016NWB027 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 81701412 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG Grant O no. O 2018CFB491 B-AWARD the O China B-ORG Scholarship I-ORG Council I-ORG no. O 201806275007 B-AWARD the O Hubei O Chenguang O Talented O Youth O Development O Foundation O Class O B O project O in O 2018 O and O the O Merck O Serono O China O Research O Fund O for O Fertility O Experts O no. O MerckSerono_CREATE-2016141 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 81272613 B-AWARD Hebei B-ORG high-level I-ORG talent I-ORG cultivation I-ORG plan I-ORG in I-ORG University I-ORG grant O numbers O GCC2014050 B-AWARD and O Key B-ORG Project I-ORG of I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG province I-ORG of I-ORG China I-ORG grant O numbers O H2017209233 B-AWARD The O funding O bodies O did O not O have O any O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O of O the O manuscript O National B-ORG Major I-ORG Scientific I-ORG Research I-ORG Instrument I-ORG Development I-ORG Project I-ORG of I-ORG China I-ORG Grant O No. O 51927804 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 61378083 B-AWARD 61405159 B-AWARD 11504294 B-AWARD Major B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 91123030 B-AWARD Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Team I-ORG Project I-ORG of I-ORG Shaanxi I-ORG Province I-ORG No. O S2018-ZC-TD-0061 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Education I-ORG Department I-ORG of I-ORG Shaanxi I-ORG Provincial I-ORG Government I-ORG No. O 18JK0791 B-AWARD College B-ORG Student I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Training I-ORG Program I-ORG of I-ORG Shaanxi I-ORG Province I-ORG No. O S202010697021 B-AWARD The O work O reported O in O this O paper O was O supported O by O The O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG during I-ORG the I-ORG Thirteenth I-ORG Five-year I-ORG Plan I-ORG Period I-ORG 2017YFC0602901 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51274250 O and O The O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG Central I-ORG South I-ORG University I-ORG 2017zzts204 O Current O study O partially O supported O by O the O Suomen B-ORG Kulttuurirahasto I-ORG grant O No. O 00190188 B-AWARD China B-ORG Scholarship I-ORG Council I-ORG CSC O No. O 201706410089 B-AWARD and O the O INFOTECH B-ORG and I-ORG the I-ORG Academy I-ORG of I-ORG Finland I-ORG project O 325097 B-AWARD The O authors O also O acknowledge O the O contribution O of O Russian B-ORG Science I-ORG Foundation I-ORG Project O 19-72-30012 B-AWARD and O Project O 22-65-00096 B-AWARD I.M O acknowledges O the O support O from O the O Leverhulme B-ORG Trust I-ORG and I-ORG The I-ORG Royal I-ORG Society I-ORG Ref O no O APX\R1\211232 B-AWARD APEX I-AWARD Awards I-AWARD 2021 O This O study O was O supported O by O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2016YFA0201600 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21777036 O 21477029 B-AWARD 91543206 B-AWARD 51673019 B-AWARD the O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG XDA09040400 O and O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Integrated I-ORG Management I-ORG of I-ORG Pest I-ORG Insects I-ORG and I-ORG Rodents I-ORG ChineseIPM1613 O This O work O was O financially O supported O by O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2018YFD0501904 B-AWARD the O Key B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Hainan I-ORG ZDKJ2016017-01 O Special O Funding O Projects O for O Local B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Guided I-ORG by I-ORG the I-ORG Central I-ORG Committee I-ORG ZY2017HN07 O the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-38 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51578526 B-AWARD 51727812 O 51525805 O by O Chongqing O Research O Program O of O Basic O Research O and O Frontier O Technology O No. O cstc2015jcyjBX0063 O and O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Chongqing I-ORG No. O cstc2018jcyjAX0327 B-AWARD and O by O Youth B-ORG Innovation I-ORG Promotion I-ORG Association I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG No. O 2016341 B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Heart I-ORG Blood I-ORG Lung I-ORG Institute I-ORG R56HL126754-01A1 O 1 B-AWARD R01 I-AWARD HL136647 O KW O is O also O supported O by O a O Gilead B-ORG CF I-ORG Research I-ORG Scholars I-ORG award I-ORG app_00b072 O and O a O UC B-ORG Davis I-ORG WCMC I-ORG pilot I-ORG grant O DK097154 O where O metabolomics O data O were O collected O This O work O was O supported O by O the O Beijing B-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospital I-ORG Clinical I-ORG Medicine I-ORG Development I-ORG of I-ORG Special I-ORG Funding I-ORG Support I-ORG ZYLX201701 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81472789 B-AWARD and O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG No. O 2014CBA02002 B-AWARD This O work O was O supported O by O the B-ORG Competitive I-ORG Allocation I-ORG of I-ORG funds I-ORG project I-ORG of I-ORG comprehensive I-ORG strategic I-ORG cooperation I-ORG Between I-ORG Guangdong I-ORG Province I-ORG and I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG grant O numbers O 2013B091100011 B-AWARD Natural O Science O Foundation O of O Guangdong O Province O in O 2017 O ‘Regulation O mechanism O of O altered O hepatic O glucose O production O of O bioactive O combinatorial O saponins O fromMomordica O charantiaassociated O with O AMPK O phosphorylation’ O Innovative B-ORG Research I-ORG Team I-ORG Project I-ORG for I-ORG Modern I-ORG Agricultural I-ORG Industry I-ORG Technology I-ORG System I-ORG of I-ORG Guangdong I-ORG Province I-ORG grant O numbers O 2016LM2151 B-AWARD and O the B-ORG Guangdong I-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG grant O numbers O 2016B070701012 B-AWARD 2016A040403081 O This O research O was O funded O by O the B-ORG Instituto I-ORG de I-ORG Salud I-ORG Carlos I-ORG III/Agencia O Estatal O de O Investigación O PI18/00825 O “Dieta O y O actividad O física O en O embarazo O y O tras O el O nacimiento O y O longitud O del O telómero O en O niños O y O adolescentes O Proyecto O TeloDiPA” O and O European O Regional O Development O Fund O ERDF O “Una O manera O de O hacer O Europa” O the B-ORG Generalitat I-ORG Valenciana I-ORG GVA/2021/191 O CIAICO/2021/132 B-AWARD the O Instituto O de O Salud O Carlos O III O FIS-PI09/00090 O PI04/2018 B-AWARD PI09/02311 B-AWARD PI13/02429 B-AWARD PI16/1288 B-AWARD PI18/00909 B-AWARD PI19/1338 B-AWARD and O FIS-PI18/01142 B-AWARD incl O ERFD B-ORG funds O PS20/0006 B-AWARD the O Department B-ORG of I-ORG Health I-ORG of I-ORG the I-ORG Basque I-ORG Government I-ORG 2013111089 O the O Instituto O de O Salud O Carlos O III O FIS-PI13/02187 O and O FIS-PI18/01142 O incl O ERFD O funds O the O Department O of O Health O of O the O Basque O Government O 2015111065 O and O the O Provincial B-ORG Government I-ORG of I-ORG Gipuzkoa I-ORG DFG15/221 O and O annual O agreements O with O the O municipalities O of O the O study O area O Zumarraga O Urretxu O Legazpi O Azkoitia O y O Azpeitia O y O Beasain O Obra O Social O Cajastur/Fundación O Liberbank O and O Universidad O de O Oviedo O and O Gobierno O de O España O through O Ministerio B-ORG de I-ORG Universidades I-ORG under O the O grants O CAS21/00008 B-AWARD and O NextGenerationEU O DPB O was O supported O by O the O Miguel O Hernández O University O Ayudas O Movilidad O Internacional O 2021 O Erasmus O 2021 O during O the O development O of O this O study O In O addition O DM O holds O a O postdoctoral O grant O by O the O Flemish B-ORG Scientific I-ORG Fund I-ORG FWO O grant O 12X9620N B-AWARD The O funders O had O no O role O in O the O design O of O the O study O collection O management O analysis O and O interpretation O of O the O data O preparation O review O or O approval O and O submission O of O the O manuscript O The O APC O was O funded O by O PI18/00825 O This O study O was O supported O in O part O by O Taiwan B-ORG Ministry I-ORG of I-ORG Health I-ORG and I-ORG Welfare I-ORG Clinical I-ORG Trial I-ORG Center I-ORG MOHW109-TDU-B-212-114004 O China B-ORG Medical I-ORG University I-ORG CMU110-AWARD-01 O and O China B-ORG Medical I-ORG University I-ORG Hospital I-ORG DMR-HHC-110-4 O DMR-112-009 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 11472031 B-AWARD 11572028 B-AWARD National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG 2017YFB0702501 O of O China O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20161366 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31371887 O the B-ORG 111 I-ORG Project I-ORG from I-ORG Education I-ORG Ministry I-ORG of I-ORG China I-ORG B07049 O and O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-28 O This O work O was O supported O by O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Program I-ORG of I-ORG China I-ORG No. O 2018ZX10713001 B-AWARD to O YS O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG of I-ORG China I-ORG No. O 2016YFC1201900 B-AWARD to O JC) O and O the O Scientific B-ORG Research I-ORG Project I-ORG of I-ORG Health I-ORG Department I-ORG Heilongjiang I-ORG Province I-ORG No. O 2011-202 I-AWARD to O FY O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Office B-ORG of I-ORG the I-ORG Assistant I-ORG Secretary I-ORG of I-ORG Defense I-ORG for I-ORG Health I-ORG Affairs I-ORG through O the O Reconstructive O Transplant O Research O Program O Technology/Investigator-Initiated O Research O Award O under O Award O No. O W81XWH-16-RTRP-IIRA B-AWARD Opinions O interpretations O conclusions O and O recommendations O are O those O of O the O authors O and O are O not O necessarily O endorsed O by O the O Department B-ORG of I-ORG Defense I-ORG W81XWH-17-1-0630 O This O work O was O funded O by O the O Texas B-ORG Engineering I-ORG Experiment I-ORG Station I-ORG TEES O through O a O TEES O Professorship O to O A.G.-E O TEES-246413 O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG #31260264 O the B-ORG High I-ORG Talent I-ORG Introduction I-ORG Project I-ORG of I-ORG Yunnan I-ORG province I-ORG #2013HA026 O and O the O National B-ORG Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases O National O Institutes O of O Health O NIH O U19AI089672 O Work O on O absence O seizures O in O our O labs O has O been O or O is O supported O by O the O Wellcome B-ORG Trust I-ORG grant O 91882 B-AWARD to O V.C O the O MRC B-ORG grant O G0900671 B-AWARD to O V.C O the O EU O grant O ITN B-ORG Marie I-ORG Sklodowska-Curie I-ORG 722053 B-AWARD to O V.C O grant O COST B-ORG Action I-ORG CM1103 B-AWARD to O G.D O the O CNRS B-ORG grant O LIA B-AWARD 528 I-AWARD to O N.L O R.C.L O and O V.C O the O Malta B-ORG Council I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG MCST I-ORG R&I I-ORG grant O R&I-2013-014 B-AWARD to O G.D O and O V.C O the O Hungarian B-ORG Scientific I-ORG Research I-ORG Fund I-ORG grant O NN125601 B-AWARD to O M.L.L O and O the O Hungarian B-ORG Brain I-ORG Research I-ORG Program I-ORG grant O KTIA_NAP_13-2-2014-0014 B-AWARD to O M.L.L O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 91648109 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2016M591774 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20160520 O BK20160544 B-AWARD Natural O science O fund O for O colleges O and O universities O in O Jiangsu O Province O 16KJB460005 O and O Senior O Talent O Scientific O Research O Fund O of O Jiangsu O University O 15JDG035 O This O research O was O funded O by O professor O Keqiang O Zhang O And O this O research O received O founding O from O the O Academician B-ORG Expert I-ORG Workstation I-ORG of I-ORG Yunnan I-ORG Province I-ORG 202105AF150075 O the O Major B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Yunnan I-ORG Province I-ORG 202102AE090011 O the O Modern B-ORG Agricultural I-ORG Industry I-ORG Technology I-ORG System-National I-ORG Dairy I-ORG Cow I-ORG Industry I-ORG Technology I-ORG System I-ORG CARS-36 O and O the O Youth B-ORG Foundation I-ORG for I-ORG Basic I-ORG Research I-ORG of I-ORG Yunnan I-ORG Province I-ORG 2019FD120 O The O work O is O supported O by O the O National B-ORG Sharing I-ORG Service I-ORG Platform I-ORG for I-ORG Parasite I-ORG Resources I-ORG TDRC-22 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31560179 B-AWARD 31460156 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Province I-ORG No. O 20171BAB205108 B-AWARD and O the O Student’s B-ORG Platform I-ORG for I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Training I-ORG Program I-ORG No. O 2017262 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanxi I-ORG Province I-ORG under O Grant O 201701D21059 B-AWARD a B-ORG Project I-ORG of I-ORG Key I-ORG Basic I-ORG Research I-ORG in I-ORG Humanities I-ORG and I-ORG Social I-ORG Sciences I-ORG of I-ORG Shanxi I-ORG Colleges I-ORG and I-ORG Universities I-ORG under O Grant O 20190130 B-AWARD an O Art I-ORG and I-ORG Science I-ORG Planning I-ORG Project I-ORG of I-ORG Shanxi I-ORG Province I-ORG under O Grant O 2017F06 B-AWARD and O the O Platform B-ORG and I-ORG Personnel I-ORG Specialty I-ORG of I-ORG Xinzhou I-ORG under O Grant O 20180601 B-AWARD to O JC. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O financially O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG Grant O 2017A030313188[R.-L.W. B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O 31470576[R.-L.W B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG Grant O 2019B030301007[J.-E.Z. B-AWARD This O research O was O funded O by O the O National B-ORG Key I-ORG R I-ORG I-ORG D I-ORG Program I-ORG of I-ORG China O grant O number O 2022YFD1401000 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities O grant O number O 2572022BE04 B-AWARD Fundamental O Research O Funds O for O the O Central O Universities O grant O number O 2572022DP03 B-AWARD and O Heilongjiang B-ORG Province I-ORG Postdoctoral I-ORG Funding I-ORG Program O grant O number O LBH-Z22047 B-AWARD This O work O is O supported O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2017YFE0112000 B-AWARD Shanghai B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG Grant O No. O 2017SHZDZX01 B-AWARD and O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant I-ORG Grant O No. O 2018T110346 B-AWARD and O No. O 2018M632019 B-AWARD This O study O was O supported O by O Ministry B-ORG of I-ORG Education I-ORG Youth I-ORG and I-ORG Sport I-ORG of I-ORG Czech I-ORG Republic I-ORG NPU O I I-AWARD MSMT-7778/2014 O Internal B-ORG grant I-ORG of I-ORG Faculty I-ORG of I-ORG Medicine I-ORG and I-ORG Dentistry I-ORG Palacky I-ORG University I-ORG Olomouc I-ORG LF_2015_008 O Ministry O of O Health O of O Czech O Republic O 15-30585A O and O EU B-ORG operation I-ORG program I-ORG CZ.1.07/2.3.00/30.0004 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81860755 B-AWARD 21606137 B-AWARD the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Programme I-ORG of I-ORG Ningxia I-ORG grant O number O 2018BFH02001 B-AWARD and O 2018BFH03023 B-AWARD Ningxia B-ORG University’s I-ORG First-Class I-ORG Subject I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG Construction I-ORG Project I-ORG grant O number O NXYLXK2017A06 B-AWARD This O work O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81502798 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG No.2015A030310399 O and O The B-ORG Maternal I-ORG and I-ORG Children I-ORG Nutrition I-ORG and I-ORG Care I-ORG Fund I-ORG of I-ORG Biostime I-ORG No.BINCMYF15006 O The O funding O sponsors O had O no O role O in O the O design O of O the O study O in O the O collection O analyses O or O interpretation O of O data O in O the O writing O of O the O manuscript O and O in O the O decision O to O publish O the O results O Mao O Zhang O is O funded O by O the O Welfare B-ORG Scientific I-ORG Research I-ORG Project I-ORG from I-ORG the I-ORG Chinese I-ORG Ministry I-ORG of I-ORG Health I-ORG 2015SQ00050 O the O Key B-ORG Program I-ORG Co-sponsored I-ORG by I-ORG Zhejiang I-ORG Province I-ORG and I-ORG National I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG China I-ORG 2018271879 O and O the O Welfare B-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG LGF18H150003 O These O agencies O provided O financial O support O but O were O not O involved O in O any O other O aspect O of O the O research O D.B O has O received O funding O from O an O MRC O Clinical O Research O Training O Fellowship O MR/L002043/1 O an O NIHR O Clinical O Lectureship O and O the O Academy B-ORG of I-ORG Medical I-ORG Sciences I-ORG SGL020\1087 O HH O is O a O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG NIHR O Senior O Investigator O This O study O is O part O of O the O BigData@Heart O Consortium O that O is O funded O by O the O Innovative O Medicines O Initiative-2 O Joint O Undertaking O under O grant O agreement O No. O 116074 O This O Joint O Undertaking O receives O support O from O the O European O Union’s O Horizon O 2020 O research O and O innovation O programme O and O EFPIA O it O is O chaired O by O DE O Grobbee O and O SD O Anker O partnering O with O 20 O academic O and O industry O partners O and O ESC O This O work O is O supported O by O Health O Data O Research O UK, O which O is O funded O by O the O UK O Medical B-ORG Research I-ORG Council O Engineering O and O Physical O Sciences O Research O Council O Economic O and O Social O Research O Council O Department O of O Health O and O Social O Care O England O Chief O Scientist O Office O of O the O Scottish O Government O Health O and O Social O Care O Directorates O Health O and O Social O Care O Research O and O Development O Division O Welsh O Government O Public O Health O Agency O Northern O Ireland O British O Heart O Foundation O and O Wellcome O This O study O was O supported O by O National O Institute O for O Health O Research O RP-PG-0407-10314 O Wellcome B-ORG Trust I-ORG 086091/Z/08/Z O This O study O was O supported O by O the O Farr O Institute O of O Health O Informatics O Research O at O UCL O Partners O from O the O Medical O Research O Council O Arthritis O Research O UK, O British O Heart O Foundation O Cancer O Research O UK, O Chief O Scientist O Office O Economic O and O Social O Research O Council O Engineering O and O Physical O Sciences O Research O Council O National O Institute O for O Health O Research O National O Institute O for O Social O Care O and O Health O Research O and O Wellcome O Trust O MR/K006584/1 O This O paper O represents O independent O research O part O funded O AGI O SD) O by O the O National O Institute O for O Health O Research O NIHR O Biomedical O Research O Centre O at O University O College O London O Hospitals O This O work O was O financially O supported O by O the B-ORG Major I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG for I-ORG Water I-ORG Pollution I-ORG Control I-ORG and I-ORG Treatment I-ORG Grant O No.2012ZX07103-005 O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No.2017YFC0403205 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 51809226 B-AWARD 51609209 O the O Natural O Science O Foundation O of O Jiangsu O Province O Grants O No. O BK20160471 O the O China O Postdoctoral O Science O Foundation O funded O project O Grant O No. O 2018M632390 B-AWARD the O Jiangsu O Planned O Projects O for O Postdoctoral O Research O Funds O Grant O No.2018K124C O the O Jiangsu O Funded O the O Recruitment O of O Postdoctoral O Project O Grant O No. O 2018Z051 B-AWARD This O research O was O funded O by O the O Highlands B-ORG and I-ORG Islands I-ORG Enterprise I-ORG HMS O 9353763 O Tenovus B-ORG Scotland O #G19.03 O and O Rosetrees B-ORG Trust I-ORG #A2819 O This O work O was O funded O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0201000 O the O basic I-ORG research I-ORG funding I-ORG from I-ORG Institute I-ORG of I-ORG Plant I-ORG Protection I-ORG China I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Science I-ORG S2018XM11 O and O Beijing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG Z161100001316007 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG China I-ORG 32172591 O the O Modern B-ORG Agricultural I-ORG Industrial I-ORG Technology I-ORG System I-ORG Funding I-ORG of I-ORG Shandong I-ORG Province I-ORG China I-ORG SDAIT-05 O the O Project B-ORG of I-ORG 20 I-ORG New I-ORG Items I-ORG for I-ORG Universities I-ORG in I-ORG Jinan I-ORG Shandong I-ORG No. O 202228058 B-AWARD the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-23-G13 O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG SAAS I-ORG CXGC2022D01 O CXGC2021B17 B-AWARD and O CXGC2022F20 B-AWARD and O the O Open B-ORG Project I-ORG Program I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Crop I-ORG Stress I-ORG Biology I-ORG for I-ORG Arid I-ORG Areas I-ORG NWAFU I-ORG Yangling I-ORG Shaanxi I-ORG China I-ORG CSBAA202207 O This O work O was O supported O partially O by O the O National O High-tech O R&D O Program O of O China O 015AA034601 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51772096 O 91333122 I-AWARD 51372082 I-AWARD 51402106 O and O 11504107 O Ph.D O Programs O Foundation O of O Ministry O of O Education O of O China O 20130036110012 O Par-Eu O Scholars O Program O Beijing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG Z161100002616039 O and O The B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2016JQ01 O 2015ZZD03 I-AWARD 2015ZD07 I-AWARD 2017ZZD02 O This O work O was O supported O by O the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2014AA06A514 O the O Zhejiang B-ORG Province I-ORG Public I-ORG Welfare I-ORG Technology I-ORG Application I-ORG Research I-ORG Project I-ORG LGF20B070001 O the O Key O Discipline O of O Zhejiang O Province O in O Medical O Technology O First O Class O Category O A), O and O the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Wenzhou I-ORG S20170016 O This O work O was O supported O in O part O by O American B-ORG Heart I-ORG Association I-ORG 15SDG25710441 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81571669 O 81229001 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shenzhen I-ORG JCYJ20160331185933583 O GJHZ20150316143320494 I-AWARD KQCX2015033117354154 O This O work O was O supported O by O Science B-ORG Foundation I-ORG for I-ORG Youth I-ORG of I-ORG Nanjing I-ORG University I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG 13XZR04 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG institutions I-ORG of I-ORG China I-ORG 14KJD330001 O Research B-ORG and I-ORG innovation I-ORG program I-ORG of I-ORG graduate I-ORG students I-ORG in I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG institution(CXLX13_576 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81473458 O and O 81473593 B-AWARD L. O Cardone-Noott O was O supported O by O the O Engineering B-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG EP/G03706X/1 O B. O Rodriguez O A. O Bueno-Orovio O and O A. O Mincholé O were O supported O by O B. O Rodriguez’ O Welcome B-ORG Trust I-ORG Senior I-ORG Research I-ORG Fellowship I-ORG in I-ORG Basic I-ORG Biomedical I-ORG Science I-ORG 100246/Z/12/Z O and O the O British B-ORG Heart I-ORG Foundation I-ORG Centre I-ORG of I-ORG Research I-ORG Excellence I-ORG RE/13/1/30181 O This O research O was O funded O by O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation O grant O number O 2022M721077 B-AWARD the O Hubei B-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Center I-ORG Project O grant O number O 2021-620-000-001-008 B-AWARD and O the O Construction B-ORG of I-ORG a I-ORG Modern I-ORG Agricultural I-ORG Industrial I-ORG Technology I-ORG System O grant O number O CRAS-23 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31870183 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanxi I-ORG Province I-ORG 201901D111223 O and O Southeast B-ORG Asia I-ORG Biodiversity I-ORG Research I-ORG Institute I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Y4ZK111B01 O This O work O was O supported O by O the O program O for O national O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31470995 O Key B-ORG Institute I-ORG of I-ORG Humanities I-ORG and I-ORG Social I-ORG Science I-ORG MOE I-ORG 16JJD880025 O and O the O Project B-ORG to I-ORG Research I-ORG Base I-ORG of I-ORG Capital I-ORG Distribution I-ORG Industry I-ORG ‘Study I-ORG on I-ORG the I-ORG Circulation I-ORG of I-ORG Fresh I-ORG Agricultural I-ORG Products I-ORG in I-ORG Capital’ I-ORG No.JD-YB-2019-017 O This O work O was O supported O partly O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 82071186 B-AWARD Clinical B-ORG Trials I-ORG from I-ORG the I-ORG Affiliated I-ORG Drum I-ORG Tower I-ORG Hospital I-ORG Medical I-ORG School I-ORG of I-ORG Nanjing I-ORG University I-ORG No. O 2022-LCYG-MS-05 B-AWARD National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2022YFA1105300 B-AWARD and O Jiangsu B-ORG Province I-ORG Senior I-ORG Health I-ORG Project I-ORG No. O LKZ2023014 B-AWARD The O design O and O initiation O of O the O study O were O supported O by O the O National B-ORG Key I-ORG R I-ORG I-ORG D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0505200 O Sample O collection O and O main O body O of O the O work O were O funded O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31772377 B-AWARD 31770588 B-AWARD Genome O sequencing O and O publication O costs O of O this O article O were O supported O by O the O International B-ORG Partnership I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG No. O 151853KYSB20170026 B-AWARD Scientific O Research O Foundation O of O the O Education O Department O of O Human O Resources O and O Social O Security O of O Yunnan O Province O China O and O Scientific O Research O Foundation O of O Kunming O Institute O of O Botany O Chinese O Academy O of O Sciences O The O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31671721 O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2015CB150205 O and O the O Program B-ORG for I-ORG New I-ORG Century I-ORG Excellent I-ORG Talents I-ORG in I-ORG University I-ORG NCET110172 O This O study O was O supported O by O grants O from O the O Young B-ORG Backbone I-ORG Support I-ORG Project I-ORG of I-ORG China I-ORG Medical I-ORG University I-ORG No. O QGZ2018067 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province I-ORG No. O 20180550420 B-AWARD and O the O Liaoning B-ORG Province I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Guidance I-ORG Plan I-ORG Project I-ORG No. O 2019 B-AWARD JH8/10300015 O This O study O was O funded O by O the O SNSF B-ORG 3100A0-133032/1 O and O 31003A-149605 B-AWARD to O MRS-V O 31003A-149506 B-AWARD to O TMS O the O Forschungskredit B-ORG of I-ORG the I-ORG University I-ORG of I-ORG Zurich I-ORG No. O 8264 B-AWARD to O CK) O and O the O JSPS B-ORG KAKENHI I-ORG 26800270 O Grant-in-Aid I-AWARD for I-AWARD Young I-AWARD Scientists I-AWARD B I-AWARD to O SH O The O research O of O AVDG O was O co-financed O by O the O European B-ORG Union I-ORG European I-ORG Social I-ORG Fund I-ORG and I-ORG Greek I-ORG national I-ORG funds I-ORG through O the O Operational O Program O “Education O and O Lifelong O Learning” O of O the O National O Strategic O Reference O Framework O NSRF)-Research O Funding O Program O THALIS–UOA O “Island O biodiversity O and O cultural O evolution” O MIS375910 O KA:70/3/11669 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O is O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 81571481 B-AWARD and O no.81370737 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG of O China O 2017CFA017 B-AWARD and O Medical B-ORG Science I-ORG Advancement I-ORG Program I-ORG Basic I-ORG Medical I-ORG Sciences I-ORG of I-ORG Wuhan I-ORG University O grant O no. O TFJC2018001 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O U1866212 B-AWARD the O Foundation B-ORG for I-ORG Fundamental I-ORG Research I-ORG of I-ORG China I-ORG Grant O No. O JSZL2016110B003 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2018M633460 B-AWARD and O the O 111 B-ORG project I-ORG Grant O No. O B12026 B-AWARD This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFA09013400 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21908239 O and O the O Tianjin B-ORG Synthetic I-ORG Biotechnology I-ORG Innovation I-ORG Capacity I-ORG Improvement I-ORG Project I-ORG TSBICIP-PTJS-001 O J.S.C O is O a O Meinig O Family O Investigator O in O the O Life O Sciences O This O work O is O based O on O research O conducted O at O the O NE-CAT O beamlines O 24-ID-C O and O 24-ID-E O under O the O under O the O general O user O proposals O GUP-51113 O and O GUP-41829 O PI: O J.S.C O NE-CAT O beamlines O are O funded O by O the O National O Institute O of O General O Medical O Sciences O from O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG P30 O GM124165];The O Pilatus O 6M O detector O on O 24-ID-C O beam O line O is O funded O by O a O NIH-ORIP B-ORG HEI I-ORG grant O S10 O RR029205 O This O research O used O resources O of O the O Advanced O Photon O Source O a O U.S B-ORG Department I-ORG of I-ORG Energy I-ORG DOE O Office O of O Science O User O Facility O operated O for O the O DOE O Office O of O Science O by O Argonne O National O Laboratory O DE-AC02-06CH11357 O Funding O for O open O access O charge O Laboratory O departmental O funds O This O work O was O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grant O No. O BK2012760 B-AWARD College B-ORG Students I-ORG Innovation I-ORG Project I-ORG for I-ORG the I-ORG R&D I-ORG of I-ORG Novel I-ORG Drugs I-ORG Grant O No. O J1310032 B-AWARD National O College O Students O innovation O and O entrepreneurship O training O program O Grant O No. O 201810316057G O and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No. O 2632018ZD09 B-AWARD National B-ORG Nature I-ORG Scientific I-ORG Foundation I-ORG of I-ORG China I-ORG 61561036 O 61702290 B-AWARD Program O for O Young B-ORG Talents I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG in I-ORG Universities I-ORG of I-ORG Inner I-ORG Mongolia I-ORG Autonomous I-ORG Region I-ORG NJYT-18-B01 O Fund B-ORG for I-ORG Excellent I-ORG Young I-ORG Scholars I-ORG of I-ORG Inner I-ORG Mongolia I-ORG 2017JQ04 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O in O part O by O The B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG Health I-ORG Planning I-ORG Commission I-ORG Foundation I-ORG of I-ORG Jilin I-ORG Province I-ORG Grand O No. I-AWARD 20152027 O the B-ORG Special I-ORG Health I-ORG Foundation I-ORG of I-ORG Jilin I-ORG Province I-ORG Grand O No. I-AWARD 3D5177793429 O the B-ORG Social I-ORG Development I-ORG Foundation I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Jilin I-ORG Province I-ORG Grand O No. I-AWARD 20170204046SF O This O study O was O supported O by O Province B-ORG science I-ORG and I-ORG technology I-ORG in I-ORG the I-ORG Anhui I-ORG offends I-ORG pass I-ORG item I-ORG No. O 1604a0802072 B-AWARD 2016 O Anhui B-ORG provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 1708085QH220 B-AWARD 2017 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81172172 B-AWARD 2011 O This O study O was O supported O by O the O foundation O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFC1309004 B-AWARD Chinese B-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG CAMS I-ORG Initiative I-ORG for I-ORG Innovative I-ORG Medicine I-ORG No. O 2016-I2M-1-002 B-AWARD 2017-I2M-1-005 B-AWARD National B-ORG Human I-ORG and I-ORG Population I-ORG Scientific I-ORG Data I-ORG Sharing I-ORG Platform I-ORG No. O 2015KJRK1L01 B-AWARD and O Pathology B-ORG Research I-ORG Center I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG No. O 2016ZX310176-2 B-AWARD This O research O was O funded O by O Jiangsu B-ORG Province’s I-ORG Outstanding I-ORG Medical I-ORG Academic I-ORG Leader I-ORG program I-ORG CXTDA2017029 O Nanjing B-ORG Medical I-ORG Technology I-ORG Development I-ORG Funds I-ORG YKK16220 O Nanjing B-ORG Medical I-ORG Science I-ORG and I-ORG technique I-ORG Development I-ORG Foundation I-ORG QRX17197 O and O Jiangsu B-ORG Program I-ORG for I-ORG Young I-ORG Medical I-ORG Talents I-ORG QNRC2016528 O The O iHealt(H O study O is O primarily O supported O by O grant O 10111501 B-AWARD by O the O Health B-ORG and I-ORG Medical I-ORG Research I-ORG Fund I-ORG Food O and O Health O Bureau O Government O of O the O Hong O Kong O SAR O PR O of O China O and O to O a O smaller O extent O by O grant O 5R01HL111378 B-AWARD 02 I-AWARD by O the O National B-ORG Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute–National I-ORG Institutes I-ORG of I-ORG Health I-ORG USA O The O funding O bodies O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O EC O is O supported O by O an O Australian B-ORG Research I-ORG Council I-ORG Future O Fellowship O FT3 O 140100085 O This O work O was O financially O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 52201178 B-AWARD Natural B-ORG Science I-ORG Research I-ORG Project I-ORG of I-ORG Colleges I-ORG and I-ORG Universities I-ORG in I-ORG Hebei I-ORG Province I-ORG grant O no. O QN2022005 B-AWARD Scientific B-ORG Research I-ORG Project I-ORG of I-ORG Student I-ORG Science I-ORG and I-ORG Technology I-ORG Fund I-ORG KBY202204 O National B-ORG Project I-ORG of I-ORG Undergraduate I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG grant O no. O 202210077001 B-AWARD and O Guide B-ORG Local I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Development I-ORG of I-ORG Hebei I-ORG Provincial I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 206Z1501G O This O research O was O funded O by O Fundação B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG a I-ORG Tecnologia I-ORG FCT O through O the O individual O grant O with O number O 2020.04531.BD B-AWARD through O the O support O of O CERENA B-ORG Strategic O Project O FCT-UIDB/04028/2020 B-AWARD and O through O the O support O of O CDRSP B-ORG Strategic O Projects O UIDB/04044/2020 B-AWARD and O UIDP/04044/2020 B-AWARD and O Associate B-ORG Laboratory I-ORG ARISE I-ORG LA/P/0112/2020 B-AWARD The O research O was O also O funded O by O the O Portugal2020 B-ORG projects I-ORG “Low I-ORG carbon I-ORG concrete I-ORG organic I-ORG shape I-ORG structures I-ORG by I-ORG 3D I-ORG printing” I-ORG reference O POCI-01-0247-FEDER-047074 B-AWARD and O “Add.Mortar-sistema B-ORG de I-ORG extrusão I-ORG para I-ORG fabrico I-ORG aditivo I-ORG com I-ORG argamassa” I-ORG reference O CENTRO-01-0145-FEDER-181263 B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81372571 B-AWARD the O Sun B-ORG Yat-Sen I-ORG University I-ORG Clinical I-ORG Research I-ORG 5010 I-ORG Program I-ORG No. O 2012010 B-AWARD the O State B-ORG “973 I-ORG Program” I-ORG of I-ORG China I-ORG No. O 2014CB542005 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 17ykzd34 B-AWARD This O research O was O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31401820 O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG KJQN201538 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province O China O BK20140702 O and O Agricultural B-ORG Independent I-ORG Innovation I-ORG Fund I-ORG of I-ORG Jiangsu I-ORG Province I-ORG China I-ORG CX(11)4004 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31771841 O and O 31501246 B-AWARD the B-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2013B020301014 O 2013B050800021 I-AWARD 2015A030313565 I-AWARD 2015B020231006 I-AWARD 2016B020201003 I-AWARD 2017A030311007 O the B-ORG Modern I-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG CARS-13 O the B-ORG Research I-ORG and I-ORG Demonstration I-ORG of I-ORG Agricultural I-ORG Technology I-ORG Demand I-ORG in I-ORG Guangdong I-ORG 2016LM3161 O 2016LM3164 O the B-ORG Key I-ORG Discipline I-ORG Construction I-ORG of I-ORG the I-ORG Guangdong I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG 201609 O and O the B-ORG Special I-ORG Foundation I-ORG of I-ORG President I-ORG of I-ORG the I-ORG Guangdong I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG 201831 O This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0200400 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31420103919 O 31571982 B-AWARD 31772171 B-AWARD Funds B-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG from I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG CAAS-XTCX2016015 O the B-ORG Agriculture I-ORG Research I-ORG System I-ORG of I-ORG China I-ORG CARS-23-D-02 O and O Hunan B-ORG Talent I-ORG Project I-ORG 2016RS2019 O None O of O the O funding O bodies O played O any O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O financially O supported O by O the B-ORG Sichuan I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG No. O 2019YJ0257 B-AWARD the O National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31902153 B-AWARD and O the B-ORG Program I-ORG of I-ORG the I-ORG National I-ORG Beef I-ORG Cattle I-ORG and I-ORG Yak I-ORG Industrial I-ORG Technology I-ORG System I-ORG No. O CARS-37 B-AWARD The O funding O body O had O no O role O in O the O design O of O the O study O sample O collection O data O analysis O and O manuscript O writing O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 31873034 B-AWARD the O China B-ORG Agricultural I-ORG University—DaBeinong I-ORG Group I-ORG Professional I-ORG Degree I-ORG Graduate I-ORG Joint I-ORG Training I-ORG Reform I-ORG Project I-ORG grant O number O CAU-DBN B-AWARD PDG-JTRP O and O the O Key B-ORG R&D I-ORG Plan I-ORG of I-ORG Hainan I-ORG Province I-ORG Project O No. O ZDYF2023XDNY038 B-AWARD This O work O was O supported O by O the O Brazilian B-ORG National I-ORG Council I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Development I-ORG CNPQ O process O number O 128495/2020-0 B-AWARD São B-ORG Paulo I-ORG Research I-ORG Foundation I-ORG FAPESP O processes O number O 2017/11259-6 B-AWARD 2019/13570-6 B-AWARD 2019/13716-0 B-AWARD 2021/15016-6 B-AWARD and O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior—Brasil I-ORG CAPES)—Finance O Code O 001 B-AWARD This O study O was O supported O by O grants O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 91332201 O 81071019 I-AWARD 81500907 I-AWARD 31471027 O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG 13JC1401501 O and O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG Foundation I-ORG of I-ORG China I-ORG 2016YFC1306403 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 22008038 B-AWARD the O Open O Fund O for O Key B-ORG Lab I-ORG of I-ORG Guangdong I-ORG High I-ORG Property I-ORG and I-ORG Functional I-ORG Macromolecular I-ORG Materials O grant O number O 20170004 B-AWARD and O the O Qingyuan B-ORG Science I-ORG and I-ORG Technology I-ORG Project O grant O number O 2021SJXM020 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81973131 B-AWARD 81903395 B-AWARD 82003520 B-AWARD and O 81803319 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2021YFC2500400 O and O the O Basic B-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG 2021B1515420007 O This O research O was O supported O by O grant O from O the B-ORG Ministry I-ORG of I-ORG Agriculture I-ORG of I-ORG China I-ORG for I-ORG Transgenic I-ORG Research I-ORG 2018ZX08009003 O and O 2018ZX0800920B B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31830064 O and O 31671652 B-AWARD Jiangsu B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Program I-ORG BE2017368 O the B-ORG Project I-ORG for I-ORG Major I-ORG New I-ORG Varieties I-ORG of I-ORG Agriculture I-ORG in I-ORG Jiangsu I-ORG Province I-ORG PZCZ201701 O Jiangsu B-ORG Natural I-ORG Science I-ORG Foundation I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG BK30180024 O and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG KYTZ201601 O This O work O was O also O supported O by O the O Key O Laboratory O of O Biology O Genetics O and O Breeding O of O Japonica O Rice O in O Mid-lower O Yangtze O River O Ministry O of O Agriculture O P.R O China O and O the O Jiangsu O Collaborative O Innovation O Center O for O Modern O Crop O Production O The O funding O organizations O played O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O funded O by O Centro B-ORG de I-ORG Química I-ORG Estrutural I-ORG is O a O Research O Unit O RU) O funded O by O Fundação B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG Tecnologia O projects O UIDB/00100/2020 B-AWARD and O UIDP/00100/2020 B-AWARD Institute B-ORG of I-ORG Molecular I-ORG Sciences I-ORG is O an O Associate O Laboratory O funded O by O FCT O project O LA/P/0056/2020 B-AWARD Research B-ORG Institute I-ORG for I-ORG Medicines I-ORG is O a O RU O funded O by O FCT O project O UIDB/04138/2020 B-AWARD and O UIDP/04138/2020 B-AWARD IBEB B-ORG is O a O RU O funded O by O FCT O project O UIDB/00645/2020 B-AWARD and O UIDP/00645/2020 B-AWARD BioISI B-ORG is O a O RU O funded O by O FCT O projects O UIDB/04046/2020 B-AWARD and O UIDP/04046/2020 B-AWARD Authors O also O acknowledge O financial B-ORG support I-ORG by O project O PTDC/BIA-BQM/28355/2017 B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Institute I-ORG on I-ORG Aging I-ORG AG049503 O the O National B-ORG Institute I-ORG on I-ORG Alcohol I-ORG Abuse I-ORG and I-ORG Alcoholism I-ORG AA021492 O the O National B-ORG Institute I-ORG on I-ORG Drug I-ORG Abuse I-ORG DA15035 O and O the O National B-ORG Cancer I-ORG Institute I-ORG CA169807 O CA178331 B-AWARD at O the O National O Institutes O of O Health O This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Grants O No. O 2017YFD0300100 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grants O No. O BK20180537 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG funded I-ORG project I-ORG Grants O No. O 2017M621757 B-AWARD and O the O Jiangsu B-ORG Province I-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG funded I-ORG project I-ORG Grants O No. O 2018K230C B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanxi I-ORG Province I-ORG grant B-AWARD number I-AWARD 201701D21059 O the O Key B-ORG Research I-ORG Base I-ORG Project I-ORG of I-ORG Humanities I-ORG and I-ORG Social I-ORG Sciences I-ORG in I-ORG Colleges I-ORG and I-ORG universities I-ORG of I-ORG Shanxi I-ORG Province I-ORG 20190130 B-AWARD the O Art B-ORG and I-ORG Science I-ORG Planning I-ORG Project I-ORG of I-ORG Shanxi I-ORG Province I-ORG grant B-AWARD number I-AWARD 2017F06 O the O Platform B-ORG and I-ORG Personnel I-ORG Specialty I-ORG of I-ORG Xinzhou I-ORG 20180601 B-AWARD and O the O Education B-ORG Science I-ORG Planning I-ORG Project I-ORG of I-ORG the I-ORG 13th I-ORG Five-year I-ORG Plan I-ORG of I-ORG the I-ORG Key I-ORG Discipline I-ORG Project I-ORG of I-ORG Shanxi I-ORG province I-ORG grant B-AWARD number I-AWARD GH-17059 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O authors O would O like O to O thank O the O Ministry B-ORG of I-ORG Education I-ORG Science I-ORG and I-ORG Technological I-ORG Development I-ORG of I-ORG the I-ORG Republic I-ORG of I-ORG Serbia O Project O No. O 451-03-47/2023-01/200134 B-AWARD the O European B-ORG Cooperation I-ORG in I-ORG Science I-ORG and I-ORG Technology I-ORG COST O Action I-AWARD Essence I-AWARD CA1911 O and O the O Technology B-ORG Agency I-ORG of I-ORG the I-ORG Czech I-ORG Republic O grant O number O TN02000020 B-AWARD for O their O financial O support O EuroHeart B-ORG II I-ORG project O grant O number O 2010 B-AWARD 12 I-AWARD 04 I-AWARD funded O all O partners O from O 2009 O to O 2013 O In O addition O to O the O EuroHeart O grant O The O Social O and O Public O Health O Sciences O Unit O in O Glasgow O is O funded O by O theMedical O Research I-ORG Council(MC_UU_12017/5 O and O theChief O Scientist I-ORG Office I-ORG of I-ORG the I-ORG Scottish I-ORG Government I-ORG Health I-ORG Directorates(SPHSU2 O This O research O was O funded O by O National B-ORG Institute I-ORG of I-ORG Cancers I-ORG UH3CA239682 O National B-ORG Institute I-ORG of I-ORG Dental I-ORG and I-ORG Craniofacial I-ORG Research I-ORG R01DE030682 O and O R01DE030682-02S1 B-AWARD of O the O National O Institutes O of O Health O NIH O Tobacco-Related B-ORG Disease I-ORG Research I-ORG Program I-ORG T31IR1825 O H.W O is O partially O supported O by O the O startup O funds O No. O WIUCASQD2021014 B-AWARD and O No. O WIUCASQD2022005 B-AWARD from O the O Wenzhou B-ORG Institute I-ORG University I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG UCAS O Z.C.O.Y O was O supported O by O the O Major B-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O under O Grant O No. O 22193032 B-AWARD R.P O acknowledges O the O support O of O UCAS O and O funding O from O the O Key B-ORG Program I-ORG of I-ORG NSFC I-ORG under O Grant O No.12034019 O This O work O was O supported O by O the O financial O support O from O the O National O Natural O Science O Foundation O of O China B-ORG Youth I-ORG Fund I-ORG No. O 51605356 B-AWARD the B-ORG 111Project I-ORG B17034 O and O the B-ORG Innovative I-ORG Research I-ORG Team I-ORG Development I-ORG Program I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG No. O IRT_17R83 B-AWARD the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG WUT:2019III112CG O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2018YFB1106700 B-AWARD Wuhan B-ORG University I-ORG of I-ORG Technology I-ORG Technology O Transfer O Jingmen O Center O Industrial O Fund O Project O WHUTJMZX-2022JJ-07 O The O PREDIMED-Plus O trial O was O supported O by O the O official O Spanish O Institutions O for O funding O scientific O biomedical O research O CIBER O Fisiopatología O de O la O Obesidad O y O Nutrición O CIBERobn O and O Instituto O de O Salud O Carlos O III O ISCIII O through O the O Fondo O de O Investigación O para O la O Salud O FIS O which O is O co-funded O by O the O European B-ORG Regional I-ORG Development I-ORG Fund I-ORG four O coordinated O Fondo O de O Investigaciones O Sanitarias O projects O leaded O by O J.S.-S O and O J.V O including O the O following O projects O PI13/00673 O PI13/00492 O PI13/00272 O PI13/01123 O PI13/00462 O PI13/00233 O PI13/02184 O PI13/00728 O PI13/01090 O PI13/01056 O PI14/01722 O PI14/00636 O PI14/00618 O PI14/00696 O PI14/01206 O PI14/01919 O PI14/00853 O PI14/01374 O PI14/00972 O PI14/00728 O PI14/01471 O PI16/00473 O PI16/00662 O PI16/01873 O PI16/01094 O PI16/00501 O PI16/00533 O PI16/00381 O PI16/00366 O PI16/01522 O PI16/01120 O PI17/00764 O PI17/01183 O PI17/00855 O PI17/01347 O PI17/00525 O PI17/01827 O PI17/00532 O PI17/00215 O PI17/01441 O PI17/00508 O PI17/01732 O and O PI17/00926 O the O Especial O Action O Project O entitled O Implementación O y O evaluación O de O una O intervención O intensiva O sobre O la O actividad O física O Cohorte O PREDIMED-Plus O grant O to O J.S.-S O European B-ORG Research I-ORG Council I-ORG Advanced O Research I-AWARD Grant I-AWARD 2014–2019 I-AWARD 340918 O to O M.Á.M.-G O the O Recercaixa O grant O to O J.S.-S O 2013ACUP00194 O grants O from O the O Consejería O de O Salud O de O la O Junta O de O Andalucía O PI0458/2013 O PS0358/2016 O and O PI0137/2018 O a O grant O from O the O Generalitat B-ORG Valenciana I-ORG PROMETEO/2017/017 O a O SEMERGEN O grant O a O CICYT O grant O provided O by O the O Ministerio O de O Ciencia O Innovación O y O Universidades O AGL2016-75329-R O and O funds O from O the O European O Regional O Development O Fund O CB06/03 O Food O companies O Hojiblanca O Lucena O Spain O and O Patrimonio O Comunal O Olivarero O Madrid O Spain O donated O extra O virgin O olive O oil O and O the O Almond O Board O of O California O Modesto O CA, O USA O American O Pistachio O Growers O Fresno O CA, O USA O and O Paramount O Farms O Wonderful O Company O LLC O Los O Angeles O CA, O USA O donated O nuts O J.K O was O supported O by O the O “FOLIUM” O program O within O the O FUTURMed O project O entitled O Talent O for O the O medicine O within O the O future O from O the O Fundació O Institut O d’Investigació O Sanitària O Illes O Balears O This O call O was O co-financed O at O 50% O with O charge O to O the O Operational O Program O FSE O 2014-2020 O of O the O Balearic O Islands O Financial O support O was O provided O by O projects O INTRAMURAL B-ORG CSIC B-AWARD 201330E065 O PopComics B-ORG CTM2017-88080 O and O CTM2007-66635 B-AWARD from O the O Spanish B-ORG Government O Funding O was O also O provided O by O the O Catalan B-ORG Government I-ORG consolidated O research O groups O 2017SGR378 B-AWARD 2017SGR1120 B-AWARD and O 2017SGR1521 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O China B-ORG National I-ORG Key I-ORG Technologies I-ORG R&D I-ORG Program I-ORG in O the O 11th O 5-year O plan O of O China O No. O 2009BAI77B02 B-AWARD the O Hunan B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 2017JJ3082 B-AWARD and O the O Hunan B-ORG Provincial I-ORG Social I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 16YBA154 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the O Preventive B-ORG Medicine I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Provincial I-ORG Health I-ORG Department I-ORG Grant O No. O Y2013051 B-AWARD Jiangsu B-ORG Department I-ORG of I-ORG Health I-ORG Grant O No. O H201330 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81373125 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No.61402371 O Natural B-ORG Science I-ORG Basic I-ORG Research I-ORG Plan I-ORG in I-ORG Shaanxi I-ORG Province I-ORG of I-ORG China I-ORG Grant O Nos O 2015JM6317 B-AWARD The B-ORG Seed I-ORG Foundation I-ORG of I-ORG Innovation I-ORG and I-ORG Creation I-ORG for I-ORG Graduate I-ORG Students I-ORG in I-ORG NPU I-ORG Grant O No. O Z2016121 B-AWARD Z2016024 B-AWARD The O authors O gratefully O acknowledge O the O support O and O financial O assistance O provided O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O Nos O 61502230 B-AWARD 61501224 B-AWARD and O 61073197 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG under O Grant O No. O BK20150960 B-AWARD the O National O Key O R&D O Program O of O China O under O Grant O No. O 2018YFC0808500 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG of I-ORG China I-ORG under O Grant O No. O 15KJB520015 B-AWARD the O National O Engineering O Research O Center O Program O of O Communications O and O Networking O under O Grant O No. O GCZX012 B-AWARD and O the O Nanjing O Municipal O Science O and O Technology O Plan O Project O under O Grant O No. O 201608009 B-AWARD This O work O was O supported O by O the O key O project O of O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31672294 B-AWARD 31872584 B-AWARD the O Beijing B-ORG Earmarked I-ORG Fund I-ORG for I-ORG Modern I-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG Systems I-ORG SCGWZJ O 20201104-4 O the O Innovation B-ORG Capability I-ORG Support I-ORG Program I-ORG of I-ORG Shaanxi I-ORG 2018TD-021 O and O the O Se-enriched B-ORG Special I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG China I-ORG Institute I-ORG of I-ORG Se-enriched I-ORG Industry I-ORG 2018FXZX02-04 O This O work O was O financially O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG Project O 2016YFC1101201 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31901735 O and O 31600807 B-AWARD the B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG China I-ORG LY19H120002 O and O the O Project O of O State O Key O Laboratory O of O Ophthalmology O Optometry O and O Visual O Science O Wenzhou B-ORG Medical I-ORG University I-ORG K171204 O This O work O was O supported O by O the O Technology O Innovation O Program O 20011100 O funded O by O the O Ministry B-ORG of I-ORG Trade I-ORG Industry I-ORG I-ORG Energy I-ORG MOTIE O Republic O of O Korea O This O work O was O also O supported O by O the O Technology O Innovation O Program O 20009983 O funded O by O the O Ministry B-ORG of I-ORG Trade I-ORG Industry I-ORG and I-ORG Energy I-ORG MOTIE O Republic O of O Korea O Finally O this O work O was O supported O by O a O grant O 20010265 O from O the O Korea B-ORG Ministry I-ORG of I-ORG Trade I-ORG Industry I-ORG and I-ORG Energy I-ORG MOTIE I-ORG Republic I-ORG of I-ORG Korea I-ORG This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Nos O 2018YFC1312600 O 2018YFC1312601 O and O 2017YFC0110304 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81830036 B-AWARD 81771255 O and O 81971106 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Nos O BK20170363 B-AWARD and O BK20180204 B-AWARD Suzhou O Key O Medical O Centre O No. O Szzx201501 O Jiangsu O Provincial O Medical O Key O Talent O Grant O No. O ZDRCA2016040 O Scientific O Department O of O Jiangsu O Province O No. O BE2017656 O Suzhou O Science O and O Technology O No. O SS2019056 O Jiangsu O Commission O of O Health O No. O K2019001 O and O Gusu B-ORG Health I-ORG Personnel I-ORG Training I-ORG Project I-ORG No. O GSWS2019030 B-AWARD This O work O was O supported O by O the O Nanyang B-ORG Technological I-ORG University I-ORG NAP-SUG];NICHD O Intramural O Research I-AWARD Program O European B-ORG Research I-ORG Council I-ORG 695300-HKADeC-ERC-2015-AdG O This O work O was O supported O by O the O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG 2017-I2M-3001 O the O Capital B-ORG Medical I-ORG Research I-ORG and I-ORG Development I-ORG Fund I-ORG 2016-4-40112 O and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0901500 O The O study O was O supported O in O part O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U1501224 O the O Natural B-ORG Science I-ORG Foundation I-ORG Team I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2018B03031200 O the O Science B-ORG and I-ORG Technology I-ORG Developmental I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017B020226003 O and O the O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG City I-ORG 201604020118 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 91542121 O 81571603 B-AWARD 81701615 O the O Capital B-ORG Foundation I-ORG of I-ORG Medical I-ORG Developments O No: O 2016-2-4063 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG Foundation I-ORG of I-ORG Beijing I-ORG No: O Z151100004015143 B-AWARD and O China-Japan B-ORG Friendship I-ORG Hospital I-ORG Funds I-ORG for I-ORG Young I-ORG Scholars I-ORG 2014-3-QN-25 O This O research O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2017YFA0603304 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 41671149 B-AWARD and O the O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG Strategic I-ORG Priority I-ORG Research I-ORG Program I-ORG Grant O No. O XDA19040101 B-AWARD This O research O was O partly O supported O by O research O grants O of O Shenzhen B-ORG Basic I-ORG Research I-ORG Program I-ORG JCYJ20210324130209023 O Shenzhen-Hong B-ORG Kong-Macau I-ORG S&T I-ORG Program I-ORG Category O C) O SGDX20201103095002019 O Mainland-Hong B-ORG Kong I-ORG Joint I-ORG Funding I-ORG Scheme I-ORG MHKJFS O MHP/005/20 O Project B-ORG of I-ORG Strategic I-ORG Importance I-ORG Fund I-ORG P0035421 O and O Projects B-ORG of I-ORG RISA I-ORG P0043001 O from O The O Hong O Kong O Polytechnic O University O This O study O was O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG I-ORG Developmental I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC1001103 O and O the B-ORG Clinical I-ORG Research I-ORG Startup I-ORG Program I-ORG of I-ORG Southern I-ORG Medical I-ORG University I-ORG by I-ORG High-level I-ORG University I-ORG Construction I-ORG Funding I-ORG of I-ORG Guangdong I-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG LC2016ZD010 O and O Clinical B-ORG Research I-ORG Program I-ORG of I-ORG Nanfang I-ORG Hospital I-ORG Southern I-ORG Medical I-ORG University(2018CR016 O This O research O was O funded O by O Natural B-ORG Science I-ORG Research I-ORG Project I-ORG of I-ORG Educational I-ORG Department I-ORG of I-ORG Anhui I-ORG Province O grant O numbers O KJ2021A0668 B-AWARD and O KJ2020A05280 B-AWARD This O research O was O also O funded O by O Fuyang B-ORG Normal I-ORG University I-ORG Youth I-ORG Fund O grant O number O XJRCXM202233 B-AWARD and O Collaborative B-ORG Education I-ORG Project I-ORG of I-ORG Education I-ORG Ministry O grant O number O 202102153069 B-AWARD This O work O was O supported O by O grants O from O the O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG CIHR O FC O – I-AWARD MOP102532 O the O Alzheimer B-ORG Society I-ORG Canada O FC O – I-AWARD ASC I-AWARD 0516 O and O the O Canada B-ORG Foundation I-ORG for I-ORG Innovation I-ORG 10307 O D. O Arsenault O held O studentships B-AWARD from O the O CIHR O and O Physiotek O This O work O was O funded O by O grants O from O Innovative B-ORG Research I-ORG Team I-ORG Program I-ORG in I-ORG Education I-ORG Department I-ORG of I-ORG Sichuan I-ORG Province I-ORG No.2013TD0015 O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG 2015BAD12N05 O the O Integration B-ORG and I-ORG Demonstration I-ORG of I-ORG Key I-ORG Technologies I-ORG for I-ORG Duck I-ORG Industrial I-ORG in I-ORG Sichuan I-ORG Province I-ORG 2014NZ0030 O and O China B-ORG Agricultural I-ORG Research I-ORG System I-ORG CARS-43-8 O This O study O was O supported O by O CONCYTEC B-ORG Peru O under O the O contract O No O 164-2016-FONDECYT B-AWARD Lima O Peru O Incentive B-ORG for I-ORG Research I-ORG of I-ORG the I-ORG Universidad I-ORG Peruana I-ORG de I-ORG Ciencias I-ORG Aplicadas I-ORG No. O UPC-A-057-2020 B-AWARD Lima O Peru O This O research O was O supported O by O the O Bio B-ORG I-ORG Medical I-ORG Technology I-ORG Development I-ORG Program I-ORG of I-ORG the I-ORG National I-ORG Research I-ORG Foundation I-ORG NRF I-ORG funded I-ORG by I-ORG the I-ORG Korean I-ORG government I-ORG MSIT O No. O 2015M3A9B6073666 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O is O supported O by O research O grants O from O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 7174350 O Beijing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG Z161100005016021 O National B-ORG key I-ORG research I-ORG and I-ORG development I-ORG program I-ORG 2016YFC1303603 O and O State B-ORG Key I-ORG Development I-ORG Program I-ORG of I-ORG Basic I-ORG Research I-ORG of I-ORG China I-ORG 973 O programs O 2013CB530800 B-AWARD The O funding O body O had O no O involvement O in O any O stage O of O the O study O The O laboratory O is O supported O by O the O Laboratoire B-ORG d’Excellence I-ORG Revive I-ORG Investissement O d’Avenir I-AWARD ANR-10-LABX-73 O the O Fondation B-ORG Leducq I-ORG grant O 13CVD01 B-AWARD CardioStemNet B-AWARD project O and O Agence B-ORG Nationale I-ORG pour I-ORG la I-ORG Recherche I-ORG ANR O grant O RHU B-AWARD CARMMA I-AWARD ANR-15-RHUS-0003 I-AWARD This O study O was O funded O by O funds O from O Agència B-ORG de I-ORG Gestió I-ORG d’Ajuts I-ORG Universitaris I-ORG de I-ORG Recerca I-ORG AGAUR O 2017 I-AWARD SGR I-AWARD 357 I-AWARD to O Cristóbal O Richart O the O Grup B-ORG de I-ORG Recerca I-ORG en I-ORG Medicina I-ORG Aplicada I-ORG URV I-ORG 2016 O PFR-URV-B2-72 I-AWARD to O Cristóbal O Richart O the O Investigador B-ORG actiu I-ORG Program I-ORG from I-ORG the I-ORG URV I-ORG 2021-10-837-AUGUET O to O Teresa O Auguet O and O own O financing O The O SABRE O study O was O funded O at O baseline O by O the O Medical O Research O Council O Diabetes B-ORG UK I-ORG and O the O British B-ORG Heart I-ORG Foundation O At O follow-up O the O study O was O funded O by O the O Wellcome B-ORG Trust I-ORG 067100 O 37055891 B-AWARD and O 086676/7/08/Z O the O British O Heart O Foundation O PG/06/145 O PG/08/103/26133 O PG/12/29/29497 B-AWARD and O CS/13/1/30327 O and O Diabetes O UK O 13/0004774 O The O study O team O also O acknowledges O the O support O of O the O National O Institute O of O Health O Research O Clinical O Research O Network O NIHR O CRN O ADH O and O NC O work O in O a O unit O that O receives O support O from O the O UK O Medical O Research O Council O MC_UU_12019/1 O This O study O was O supported O by O the B-ORG Shenzhen I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG JCYJ20210324102607021 O Shenzhen O Double O Chain O Project O for O Innovation O and O Development O Industry O supported O by O Bureau B-ORG of I-ORG Industry I-ORG and I-ORG Information I-ORG Technology I-ORG of I-ORG Shenzhen I-ORG 201806081524201510 O Clinical O Research O Project O of O Shezhen B-ORG Second I-ORG People’s I-ORG Hospital I-ORG 20200601027-FS01 O Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG RCYX20210609103902019 O This O research O was O supported O by O the O National B-ORG Research I-ORG Council I-ORG of I-ORG Science I-ORG I-ORG Technology I-ORG NST O grant O by O MSIT O No. O CAP20013-000 B-AWARD the B-ORG Institute I-ORG of I-ORG Information I-ORG I-ORG Communications I-ORG Technology I-ORG Planning I-ORG I-ORG Evaluation I-ORG IITP I-ORG grant I-ORG funded O by O MSIT O No. O 2021-0-00725 B-AWARD Development O of O Monitoring O Intelligence O System O Technology O based O on O Multimodal O Sensing O for O Monitoring O the O Risk O of O Infectious O Diseases O in O Confined O Spaces O and O the O Korea B-ORG Research I-ORG Institute I-ORG of I-ORG Bioscience I-ORG and I-ORG Biotechnology I-ORG KRIBB O Research O Initiative O Program O KGM5472221 O and O KGM4542323 B-AWARD Finally O the O authors O acknowledge O funding O from O the O Korea B-ORG Institute I-ORG of I-ORG Planning I-ORG and I-ORG Evaluation I-ORG for I-ORG Technology I-ORG in I-ORG Food I-ORG Agriculture I-ORG and I-ORG Forestry I-ORG IPET O and O the O Korea O Smart O Farm O R&D O Foundation O KosFarm O through O the O Smart O Farm O Innovation O Technology O Development O Program O funded O by O the O Ministry O of O Agriculture O Food O and O Rural O Affairs O MAFRA O and O the O Ministry O of O Science O and O ICT O MSIT O Rural O Development O Administration O RDA O 421042-04 O The O funding O agencies O had O no O role O in O study O design O in O the O collection O analysis O and O interpretation O of O data O in O the O writing O of O the O report O and O in O the O decision O to O submit O the O article O for O publication O The O study O was O supported O by O grants O from O the O Nature B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG #81072495 O the O Science B-ORG and I-ORG Technology I-ORG Key I-ORG Projects I-ORG of I-ORG Zhejiang I-ORG province I-ORG China I-ORG #2010C33006 O 2017C03053 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Projects I-ORG of I-ORG Hangzhou I-ORG China I-ORG #20140733Q18 O 20150733Q22 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O No. O 71503068,http://www.nsfc.gov.cnand B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG in I-ORG Key I-ORG Research I-ORG Areas I-ORG for I-ORG the I-ORG Central I-ORG Universities O No. O 2015B09614 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities O No. O 2014B15114http://www.moe.edu.cn B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O financial O support O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21775117 O U21A20337 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shannxi I-ORG Province I-ORG 2020JC-06 O the O Key B-ORG R&D I-ORG Plan I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 2021SF-168 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 22127803HZ O SY6J007 B-AWARD This O work O was O supported O by O the O Natural B-ORG Science I-ORG Research I-ORG Project I-ORG of I-ORG Education I-ORG Department I-ORG of I-ORG Anhui I-ORG Province I-ORG Grant O No. O KJ2013Z332 B-AWARD Anhui B-ORG provincial I-ORG College I-ORG Students I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Program I-ORG Training I-ORG Project I-ORG Grant O NO. O AH201310368141 B-AWARD Humanities B-ORG and I-ORG Social I-ORG Science I-ORG Research I-ORG Project I-ORG of I-ORG Education I-ORG Department I-ORG of I-ORG Anhui I-ORG Province I-ORG Grant O No. O SK2019A0228 B-AWARD The O funder O had O no O influence O on O data O collection O data O analysis O or O writing O of O the O manuscript O This O study O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG contract O No. O 51775068 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2022CDJXY-010 O and O Chongqing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG general I-ORG project I-ORG No. O cstc2021jcyj-msxmX1085 B-AWARD The O present O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 81572421 B-AWARD the O Jiangsu B-ORG Provincial I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Program O grant O no. O H201555 B-AWARD and O Huai’an B-ORG Governmental I-ORG Science I-ORG Developing I-ORG program I-ORG grant O no. O HACZ2014002 B-AWARD The O funding O body O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O The O study O was O supported O by O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 7182131 B-AWARD CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences O CIFMS O No.2018-I2M-AI-004 O and O the O Non-profit B-ORG Central I-ORG Research I-ORG Institute I-ORG Fund I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG No.2019XK320004 O who O helped O with O data O collection O and O language O editing O This O study O was O financially O supported O by O the O National B-ORG Youth I-ORG Science I-ORG Fund I-ORG Project I-ORG 31301992 O Shanxi B-ORG Agricultural I-ORG University I-ORG Youth I-ORG Innovation I-ORG Talent I-ORG Support I-ORG Fund I-ORG Project I-ORG BJRC201603 O Shanxi B-ORG Youth I-ORG Science I-ORG Fund I-ORG Project I-ORG 201601D202065 O and O National O Science O Fund O Project O 31472115 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O a O research O grant O from O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Taiwan I-ORG 103-2314-B-182A-097 O NMRPG3D0381 O Chang B-ORG Gung I-ORG Memorial I-ORG Hospital I-ORG Taiwan I-ORG CMRPG3F0461 O and O St. B-ORG Paul’s I-ORG Hospital I-ORG Taiwan I-ORG SPMRP-U1-5006 O The O funders O had O no O role O in O the O design O of O this O study O nor O the O collection O analysis O and O interpretation O of O data O nor O in O the O writing O of O this O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31472021 B-AWARD the O project O for O Endangered B-ORG Wildlife I-ORG Investigation I-ORG Supervision I-ORG and I-ORG Industry I-ORG Regulation I-ORG of I-ORG the I-ORG National I-ORG Forestry I-ORG and I-ORG Grassland I-ORG Bureau I-ORG of I-ORG China I-ORG No. O 2019072-HN-001 B-AWARD and O the O project O for O Endangered B-ORG Wildlife I-ORG Protection I-ORG of I-ORG Hunan I-ORG Forestry I-ORG Bureau I-ORG of I-ORG China I-ORG No. O HNYB-2019001 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC1406505 O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31702340 O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG China I-ORG No. O 201804020073 B-AWARD Institution B-ORG of I-ORG South I-ORG China I-ORG Sea I-ORG Ecology I-ORG and I-ORG Environmental I-ORG Engineering I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG No. O ISEE2018PY03 B-AWARD This O research O was O supported O by O the O Ministry B-ORG of I-ORG Higher I-ORG Education I-ORG Malaysia’s I-ORG Fundamental I-ORG Research I-ORG Grant I-ORG Scheme I-ORG FP032-2014B O University B-ORG Malaya’s I-ORG Grant I-ORG BK018-2015 O and O University B-ORG of I-ORG Malaya’s I-ORG Postgraduate I-ORG Research I-ORG Grants I-ORG PG130-2013A O PG212-2014B B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 61561012 B-AWARD the O Guangxi B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 2014GXNSFAA118393 B-AWARD the O Guangxi B-ORG Key I-ORG Laboratory I-ORG of I-ORG Automatic I-ORG Detecting I-ORG Technology I-ORG and I-ORG Instruments I-ORG Grant O No. O YQ16106 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Research I-ORG Project I-ORG of I-ORG Guangxi I-ORG Department I-ORG of I-ORG Education I-ORG Grant O No. O KY2015YB110 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Applied B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG Sichuan I-ORG Province I-ORG Sichuan I-ORG No. O 2019YJ0549 B-AWARD Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG Seedling I-ORG engineering I-ORG program I-ORG No. O 201958 B-AWARD Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG program I-ORG No. O 2019YFG0154 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31522056 O 61705092 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2015BAD12B01 O 2018YFD0500100 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG of I-ORG China I-ORG BK20170194 O the O Priority O Academic O Program O Development O of O Jiangsu O Higher O Education O Institutions O PAPD O Jiangsu O Key O Research O and O Development O Program O BE2018709 O This O work O was O supported O by O the O National B-ORG Counsel I-ORG of I-ORG Technological I-ORG and I-ORG Scientific I-ORG Development I-ORG CNPq O process O 142211/2012-5 B-AWARD to O FBQ O Coordination B-ORG for I-ORG the I-ORG Improvement I-ORG of I-ORG Higher I-ORG Education I-ORG Personnel I-ORG CAPES O process O BEX O 14209/13-6 B-AWARD to O FBQ O and O São B-ORG Paulo I-ORG Research I-ORG Foundation I-ORG FAPESP O process O 2011/09477-9 B-AWARD to O Eduardo O Almeida O Support O was O also O provided O from O the O University B-ORG of I-ORG Minnesota I-ORG Agricultural I-ORG Experiment I-ORG Station I-ORG projects O 017-17 B-AWARD and I-AWARD 017-29 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O key O project O of O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 72033009 O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG 10-IAED-01-2022 O ASTIP-IAED-2022-01 B-AWARD the O National B-ORG Social I-ORG Science I-ORG Youth I-ORG Fund I-ORG Project I-ORG 22CGL025 O and O the B-ORG special I-ORG fund I-ORG of I-ORG basic I-ORG scientific I-ORG research I-ORG business I-ORG of I-ORG central I-ORG public I-ORG welfare I-ORG research I-ORG institutes I-ORG 1610052022028 O 161005202106 B-AWARD This O study O was O funded O by O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG Grant O No. O 201806020068 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O China O 10151006001000013 O Traditional B-ORG Chinese I-ORG Medicine I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Guangzhou I-ORG City O China O 20172A011004 O and O Medical B-ORG and I-ORG Health I-ORG Technology I-ORG General I-ORG Guidance I-ORG Project I-ORG of I-ORG Guangzhou I-ORG City O China O 20171A011025 O 20181A011002 B-AWARD This O research O was O carried O out O with O support O from O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0101500 O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31571615 O and O Program B-ORG on I-ORG Industrial I-ORG Technology I-ORG System I-ORG of I-ORG National I-ORG Soybean I-ORG CARS-04-PS19 O This O study O was O supported O by O Projects B-ORG of I-ORG Development I-ORG and I-ORG Application I-ORG of I-ORG Suitable I-ORG Health I-ORG Technology I-ORG of I-ORG Shanghai I-ORG Hospital I-ORG Development I-ORG Center I-ORG SHDC O No. O SHDC12014226 B-AWARD Three O Year O Action O Plan O for O Strengthening B-ORG Public I-ORG Health I-ORG System I-ORG in I-ORG Shanghai I-ORG No. O GWIV-12 B-AWARD Projects B-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG No. O 2016ZB0102-01 B-AWARD and O Project B-ORG of I-ORG Characteristic I-ORG Medical I-ORG Specialty I-ORG in I-ORG Minhang I-ORG Shanghai I-ORG No. O 2017MWTZ20 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDA17010503 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31800073 O Youth B-ORG Innovation I-ORG Promotion I-ORG Association I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG 2018117 O This O study O was O supported O by O the B-ORG Key I-ORG Discipline I-ORG Construction I-ORG Project I-ORG of I-ORG Acupuncture I-ORG Moxibustion I-ORG and I-ORG Massage I-ORG of I-ORG Chongqing I-ORG Health I-ORG Commission I-ORG 472020320220021 O College B-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG of I-ORG Chongqing I-ORG Medical I-ORG University I-ORG No: O 2021-ZDXK-D04 B-AWARD Joint B-ORG Project I-ORG of I-ORG Chongqing I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG and I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG No: O ZY201801007 B-AWARD and O Chongqing B-ORG Yuzhong I-ORG District I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG No: O 20200116 B-AWARD This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD1000703 O I-AWARD 2018YFD1000700 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 31571648 O the B-ORG National I-ORG Barley I-ORG and I-ORG Highland I-ORG Barley I-ORG Industrial I-ORG Technology I-ORG Specially I-ORG Constructive I-ORG Foundation I-ORG of I-ORG China I-ORG CARS-05 O and O a B-ORG Project I-ORG Funded I-ORG by I-ORG the I-ORG Priority I-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O This O work O was O partly O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC0910502 B-AWARD to O W.H.C O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61932008 O 61772368 B-AWARD 61572363 B-AWARD all O to O X.M.Z O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC0910500 O to O X.M.Z O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG 17ZR1445600 O to O X.M.Z O Shanghai B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG 2018SHZDZX01 O to O X.M.Z O and O ZJLab O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O Shanghai B-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG 2013ZYJB1001 O the O Biomedical B-ORG Engineering I-ORG Cross I-ORG Research I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG YG2015MS18 O and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2016YFC0903303 O They O have O no O role O in O study O design O data O collection O and O analysis O results O interpretation O or O in O preparation O review O and O approval O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 21776020 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province I-ORG No. O 2019-MS-019 B-AWARD and O the O Science B-ORG Foundation I-ORG of I-ORG Dalian I-ORG Polytechnic I-ORG University I-ORG No. O 61010201 B-AWARD The O research O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20192007 O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51875128 B-AWARD 51805497 I-AWARD 51605301 I-AWARD 51635005 O and O Six B-ORG Talent I-ORG Peaks I-ORG in I-ORG Jiangsu I-ORG Province I-ORG GDZB-069 O This O study O was O supported O by O grants O from O the B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Xiamen O China O NO. O 3502Z20154021 B-AWARD and O 3502Z20164023 B-AWARD the B-ORG Medical I-ORG Innovative I-ORG Project I-ORG of I-ORG Fujian I-ORG provincial I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG commission I-ORG No. O 2015-CXB-40 B-AWARD and O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81401945 B-AWARD The O funding O body O had O no O role O in O study O design O data O collection O and O analysis O interpretation O of O data O or O writing O of O the O manuscript O KDH O is O supported O by O an O Australian B-ORG Research I-ORG Council I-ORG Future I-ORG Fellowship I-ORG FT130100637 O and O an O Honorary O National B-ORG Heart I-ORG Foundation I-ORG of I-ORG Australia I-ORG Future O Leader O Fellowship O 100370 O RL O is O supported O by O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG Early O Career O Fellowship O 1089415 O The O funders O were O not O involved O in O the O design O of O the O study O the O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O funded O partly O by O a O grant O from O the O Japan B-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG KAKENHI I-ORG No. O 22K09668 B-AWARD a O Health B-ORG Labor I-ORG Sciences I-ORG Research I-ORG grant O H30-Nanchitou O Nan)-Ippan-016 O and O the O Society B-ORG for I-ORG Promotion I-ORG of I-ORG International I-ORG Oto-Rhino-Laryngology I-ORG SPIO I-ORG Japan I-ORG SODA I-ORG TOYOJI I-ORG SPIO I-ORG Research I-ORG Grant O 2022 O No. O SR22001 B-AWARD This O work O was O supported O in O part O by O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81425022 O U1501223 B-AWARD and O 41406195 B-AWARD the O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG XDA11030403 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2016A030312014 O The O research O was O funded O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31771942 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG CN) O 17ZR142600 O and O Shanghai B-ORG Local I-ORG Capacity I-ORG Building I-ORG Projects I-ORG 16090503800 O This O study O was O supported O by O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81525016 O 81772145 B-AWARD 81770013 B-AWARD Shenzhen B-ORG Science I-ORG I-ORG Technology I-ORG Grant I-ORG JSGG20160427104724699 O JCYJ20170412101048337 B-AWARD JCYJ20170412151620658 B-AWARD and O Sanming B-ORG Project I-ORG of I-ORG Medicine I-ORG in I-ORG Shenzhen I-ORG GCZX2015043015340574 O This O work O was O supported O by O the O Excellent B-ORG Youth I-ORG Fund I-ORG of I-ORG Jiangsu I-ORG Natural I-ORG Science I-ORG Foundation I-ORG BK20220116 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31801699 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Jiangsu I-ORG Province I-ORG BK2018904 O and O the B-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG High I-ORG Technology I-ORG for I-ORG Plant I-ORG Protection I-ORG zhizhong2021-07 O Funding O was O provided O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 21307076 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG of I-ORG Shandong I-ORG University I-ORG No. O 2014TB003 B-AWARD and O the O Seventh B-ORG Framework I-ORG Programme I-ORG FP7-PEOPLE-2011-IRSES B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Portugal B-ORG Foundation I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG strategic O projects O UIDB/04539/2020 B-AWARD UIDP/04539/2020 B-AWARD and O LA/P/0058/2020 B-AWARD CIBB O PTDC/DTP-DES/1082/2014 B-AWARD POCI-01-0145-FEDER-016657 O CENTRO-01-0246-FEDER-000010 B-AWARD Multidisciplinary O Institute I-ORG of I-ORG Ageing I-ORG in I-ORG Coimbra O and O FCT-Post-doctoral B-ORG Fellowship I-ORG SPP O SFRH/BPD/116061/2016 B-AWARD P.J.D O was O supported O by O an O MRC B-ORG PhD O studentship O in O the O College O of O Medicine O and O Veterinary O Medicine O University O of O Edinburgh O Work O was O supported O by O grants O to O M.J.S O and O P.R O from O the O Wellcome B-ORG Trust I-ORG 082407 O to O M.J.S O from O MRC O J008893 O and O to O R.B O and O J.T O from O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG DK43200 O This O research O was O supported O by O Portuguese O national O funds O from O FCT—Foundation O for I-ORG Science I-ORG and I-ORG Technology I-ORG through O project O UID/Multi/04326/2016 B-AWARD and O by O FCT O and O the O European B-ORG Regional I-ORG Development I-ORG Fund I-ORG FEDER O under O projects O 22153-01/SAICT/2016 B-AWARD to O the O National B-ORG Infrastruture I-ORG of I-ORG Distributed I-ORG Computing I-ORG of I-ORG Portugal O ALG-01-0145-FEDER-022121 B-AWARD and O ALG-01-0145-FEDER-022231 B-AWARD and O co-funds O from O MAR2020 B-AWARD operational O programme O of O the O European B-ORG Maritime I-ORG and I-ORG Fisheries I-ORG Fund I-ORG project O SARDINOMICS O MAR-01.04.02-FEAMP-0024 B-AWARD The O EMBRIC O configurator O service O received O funding O from O the O European O Union's O Horizon B-ORG 2020 I-ORG research O and O innovation O programme O under O grant O agreement O No. O 654008 B-AWARD Funding O for O this O work O was O provided O by O Zhejiang B-ORG Province I-ORG Health I-ORG Bureau I-ORG 2017ky062 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG LY15H030012 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No.81200267 O The O funding O sources O had O no O role O in O the O study O design O collection O analysis O and O interpretation O of O the O data O in O the O writing O of O the O report O or O in O the O decision O to O submit O the O paper O for O publication O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD1000800 O and O 2019YFD1000300 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31772358 O and O 31872158 B-AWARD and O Earmarked B-ORG Fund I-ORG for I-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG CAS-23 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61501039 O the O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2162017 O the O Beijing B-ORG Municipal I-ORG Education I-ORG Commission I-ORG KM201710015005 O the O Research O and O Development O Program O of O BIGC O Ec201808 O the O Beijing O Municipal O Science O O Technology O Commission O Z181100004418004 O the O Programme O of O Key O Technologies O of O Thin O Film O Printing O Electronics O 04190118002/042 O and O the O Programme O of O Flexible O Printed O Electronic O Materials O and O Technology O Innovation O 04190118002/092 O and O 04190118003/002 O The O authors O are O grateful O for O the O financial O support O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81202483,81773668 O Liaoning B-ORG Natural I-ORG Science I-ORG Foundation I-ORG for I-ORG Excellent I-ORG Talents I-ORG in I-ORG university I-ORG LR O 2015020543 O Scientific B-ORG Research I-ORG Foundation I-ORG for O the O Rturuned O Overseas O Chinese O Scholars O by O State O Education O Ministry O 201303003 O Science B-ORG and I-ORG Technology I-ORG project I-ORG of I-ORG Shenyang I-ORG F15-139-9-06 O F15-199-1-24 B-AWARD This O work O was O financially O supported O by O the O Natural B-ORG Sciences I-ORG Fund I-ORG for I-ORG Colleges I-ORG and I-ORG Universities I-ORG in I-ORG Jiangsu I-ORG Province I-ORG Grant O Nos O 22KJD560003 B-AWARD the O Nantong B-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG Grant O Nos O MS22022067 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 52208395 B-AWARD and O 51808298 B-AWARD This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 81660334 B-AWARD Guangxi B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2017GXNSFAA198190 O 2018GXNSFAA050099 B-AWARD National B-ORG Key I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG China I-ORG 2018ZX10101002-001-006 O and O Guangxi B-ORG Collaborative I-ORG Innovation I-ORG Center I-ORG for I-ORG Biomedicine I-ORG GCICB-IE-2018010 O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0201001 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31850410469 O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG LY18C150001 O the O Fundamental O Research O Funds O for O the O Central O Universities O 2019FZA6008 O Henan B-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG HAUST O Research O Start-up O Fund O for O New O Faculty O 13480058 O and O the O Key O Laboratory O of O Horticultural O Crop O Growth O and O Quality O Control O in O Protected O Environment O of O Luoyang O City O The O work O was O funded O by O Cancer O Research O UK O CRUK O via O core-funding O to O the O CRUK B-ORG Manchester I-ORG Institute I-ORG grant O no. O A27412 B-AWARD the O CRUK B-ORG Manchester I-ORG Centre I-ORG grant O no. O A25254 B-AWARD and O the O CRUK B-ORG Beatson I-ORG Institute I-ORG grant O no. O A17196 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O paper O was O sponsored O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81571656 I-AWARD and O No. B-AWARD 61603399 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFC0107105 B-AWARD the O Innovation B-ORG Foundation I-ORG of I-ORG Tangdu I-ORG Hospital I-ORG No. O 2016LCYJ011 B-AWARD and O Key B-ORG Project I-ORG for I-ORG Science I-ORG Research I-ORG and I-ORG Development I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 2017SF-012 O This O work O has O been O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFE0204900 O to O F.C O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81530088 O to O F.C O 81973142 B-AWARD to O Y.W O the O US O National B-ORG Institutes I-ORG of I-ORG Health I-ORG CA209414 O CA092824 I-AWARD and I-AWARD ES000002 I-AWARD to O D.C.C O The O funding O sponsors O had O no O role O in O study O design O collection O analysis O and O interpretation O of O data O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Instituto B-ORG Nacional I-ORG de I-ORG Investigación I-ORG y I-ORG Tecnología I-ORG Agraria I-ORG y I-ORG Alimentaria I-ORG INIA,http://www.inia.es O grant O RTA2014-00058-C03-01 B-AWARD JLRV O was O funded O by O the O European B-ORG Social I-ORG Fund I-ORG https://ec.europa.eu/social O fellowship O number O 01/14-FSE-0 B-AWARD and O CB O by O Generalitat B-ORG Valenciana I-ORG https://www.gva.es O ACIF/2016/117 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O grants O from O the O National O Science O and O Technology O Major O Project O 2020ZX09201021 O the O Medical O artificial O intelligence O project O of O Sun O Yat‐Sen O Memorial O Hospital O YXRGZN201902 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81572596 O 81972471 B-AWARD U1601223 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017A030313828 O the O Guangzhou O Science O and O Technology O Major O Program O 201704020131 O the O Guangdong B-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG 2017B030314026 O the O Special O Funds O for O the O Cultivation O of O Guangdong O College O Students’ O Scientific O and O Technological O Innovation O pdjh2019a0212 O National O Students’ O Innovation O and O Entrepreneurship O training O program O 201910571001 O and O Guangdong O Medical O University O College O Students’ O Innovation O Experiment O Project O ZZZF001 O This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2022MC113 O the O Project B-ORG of I-ORG Shandong I-ORG Province I-ORG Higher I-ORG Educational I-ORG Youth I-ORG Innovation I-ORG Science I-ORG and I-ORG Technology I-ORG Program O 2019RWF003 O the O Supporting B-ORG Fund I-ORG for I-ORG Teachers’ I-ORG research I-ORG of I-ORG Jining I-ORG Medical I-ORG University I-ORG JYFC2019KJ011 O JYFC2019RW007 B-AWARD the O Special B-ORG Project I-ORG of I-ORG Innovation I-ORG Quality I-ORG of I-ORG Educational I-ORG Sciences I-ORG Planning I-ORG of I-ORG Shandong I-ORG Province O 2022CYB207 O and O the O College B-ORG Students I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Training I-ORG Program I-ORG cx2021142 O This O work O was O supported O by O the O MRC B-ORG Network I-ORG of I-ORG Hubs I-ORG for I-ORG Trials I-ORG Methodology I-ORG Research I-ORG MR/L004933/1-R/N/P/B1 O GMW O was O supported O by O Cancer B-ORG Research I-ORG UK. O APM O was O supported O by O the O Medical B-ORG Research I-ORG Council I-ORG MC_UP_1302/2 O TJ O was O funded O by O a O Senior O Research O Fellowship O NIHR-SRF-2015-08-001 O supported O by O the O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research O SBL O was O funded O by O grant O C5529/A16895 B-AWARD from O Cancer O Research O UK. O CJW O was O supported O in O this O work O by O NHS O Lothian O via O the O Edinburgh O Clinical O Trials O Unit O CY O is O funded O by O grant O C22436/A15958 B-AWARD from O Cancer O Research O UK. O The O views O expressed O in O this O publication O are O those O of O the O authors O and O not O necessarily O those O of O the O NHS O the O National O Institute O for O Health O Research O or O the O Department O of O Health O This O work O was O coordinated O by O the O NIHR O Statistics O Group O Early O Phase O Clinical O Trials O section O and O the O original O workshop O generating O the O project O was O funded O by O the O NIHR O Office O for O Clinical O Research O Infrastructure O NOCRI O This O research O was O funded O by O ICSC B-ORG – I-ORG Centro I-ORG Nazionale I-ORG di I-ORG Ricerca I-ORG in I-ORG High I-ORG Performance I-ORG Computing I-ORG Big I-ORG Data I-ORG and I-ORG Quantum I-ORG Computing I-ORG funded I-ORG by I-ORG European I-ORG Union–NextGenerationEU-PNRR O Missione B-AWARD 4 I-AWARD Componente I-AWARD 2 I-AWARD Investimento I-AWARD 1.4 O R.I O and O F.S O thank O CNR B-ORG progetti@cnr/UCATAG4 O for O financial O support O Q.X O was O funded O by O the O China B-ORG Scholarship I-ORG Council I-ORG CSC O No. O 202108370212 B-AWARD and O Y.L O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 11904149 B-AWARD J.C O thanks O Ministerio B-ORG de I-ORG Universidades I-ORG Plan I-ORG de I-ORG Recuperación I-ORG Transformación I-ORG y I-ORG Resiliencia I-ORG and I-ORG UAM I-ORG for O funding O the O research O stay O in O Pisa O with O a O requalification O program O CA2/RSUE/2021-00890 O This O research O was O funded O by O the O Scientific B-ORG and I-ORG Technological I-ORG Innovation I-ORG of I-ORG Blue I-ORG Granary I-ORG grant O no. O 2018YFD0900402 B-AWARD the O Key B-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 31830103 B-AWARD and O the O National O Natural O Science O Foundation O of O China O Shan O Dong O grant O no. O U2106232 B-AWARD This O research O was O funded O by O Jinggangshan B-ORG University I-ORG Doctoral I-ORG Research I-ORG Project I-ORG Grant O No. O JRB2201 B-AWARD Guangxi B-ORG Philosophy I-ORG and I-ORG Social I-ORG Science I-ORG Planning I-ORG Research I-ORG Project I-ORG Grant O No. O 18FGL007 B-AWARD 2022 B-ORG Shanghai I-ORG Philosophy I-ORG and I-ORG Social I-ORG Science I-ORG Planning I-ORG Project I-ORG Grant O No. O 2022ZJB007 B-AWARD and O Shanghai B-ORG Pujiang I-ORG Program I-ORG Grant/Award O No. O 22PJC042 B-AWARD This O study O was O funded O by O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 30701074 B-AWARD and I-AWARD 81373523 O the O Postdoctoral B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 200403649 B-AWARD and O the O Innovation B-ORG Fundation I-ORG of I-ORG Guangzhou I-ORG University I-ORG of I-ORG Chinese I-ORG Medicine(grant O number O k2004039 B-AWARD This O material O is O based O upon O work O funded O by O the O Nature O and O Science O Foundation O of O China O Grant O No. O 81570869 O Nature O and O Science O Foundation O of O Zhejiang O Province O China O Grant O No. O Y2110784 O Zhejiang B-ORG Provincial I-ORG Foundation I-ORG of I-ORG China I-ORG for I-ORG Distinguished I-ORG Young I-ORG Talents I-ORG in I-ORG Medicine I-ORG and I-ORG Health I-ORG Grant O No. B-AWARD 2010QNA018 O Foundation B-ORG of I-ORG Wenzhou I-ORG City I-ORG Science I-ORG I-ORG Technology I-ORG Bureau I-ORG Grant O No. B-AWARD Y20140705 O and O Engineering B-ORG Development I-ORG Project I-ORG of I-ORG Ophthalmology I-ORG and I-ORG Optometry I-ORG Grant O No. B-AWARD GCKF201601 O The O funding O sources O were O not O involved O in O any O part O of O this O study O This O research O was O partly O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 82071186 B-AWARD and O Clinical B-ORG Trials I-ORG from I-ORG the I-ORG Affiliated I-ORG Drum I-ORG Tower I-ORG Hospital I-ORG Medical I-ORG School I-ORG of I-ORG Nanjing I-ORG University I-ORG No. O 2022-LCYG-MS-05 B-AWARD National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2022YFA1105300 B-AWARD and O Jiangsu B-ORG Province I-ORG Senior I-ORG Health I-ORG Project I-ORG No. O LKZ2023014 B-AWARD None O of O the O authors O have O a O conflict O of O interest O financial O or O otherwise O directly O or O indirectly O related O to O this O work O This O work O was O supported O by O National B-ORG Genetically I-ORG Modified I-ORG New I-ORG Varieties I-ORG of I-ORG Major I-ORG Projects I-ORG of I-ORG China I-ORG 2015ZX08002-004 O 2015ZX08010-004 O International B-ORG S I-ORG I-ORG T I-ORG Cooperation I-ORG Key I-ORG Projects I-ORG of I-ORG Chinese I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG grant O No. O 2009DFB30340 B-AWARD Research B-ORG Fund I-ORG for I-ORG the I-ORG Doctoral I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG of I-ORG China I-ORG Grant O no. O 2012014211075 B-AWARD Open B-ORG Research I-ORG Fund I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Hybrid I-ORG Rice I-ORG in I-ORG Wuhan I-ORG University I-ORG in I-ORG China I-ORG Grant O no. O KF201302 B-AWARD The O SGC O is O a O registered O charity O number O 1097737 O that O receives O funds O from O AbbVie B-ORG Bayer I-ORG Pharma I-ORG AG, I-ORG Boehringer I-ORG Ingelheim I-ORG Canada I-ORG Foundation I-ORG for I-ORG Innovation I-ORG Eshelman I-ORG Institute I-ORG for I-ORG Innovation I-ORG Genome I-ORG Canada I-ORG Innovative I-ORG Medicines I-ORG Initiative I-ORG EU/EFPIA O ULTRA-DD O grant O no. O 115766 B-AWARD Janssen B-ORG Merck I-ORG KGaA I-ORG Darmstadt I-ORG Germany I-ORG MSD I-ORG Novartis I-ORG Pharma I-ORG AG, I-ORG Ontario I-ORG Ministry I-ORG of I-ORG Economic I-ORG Development I-ORG and I-ORG Innovation I-ORG Pfizer I-ORG São I-ORG Paulo I-ORG Research I-ORG Foundation-FAPESP I-ORG Takeda I-ORG and I-ORG Wellcome I-ORG 106169/ZZ14/Z O This O work O was O partly O supported O by O the O NIH B-ORG Common I-ORG Fund I-ORG Illuminating I-ORG the I-ORG Druggable I-ORG Genome I-ORG IDG I-ORG program I-ORG NIH O Grant O U24DK116204 B-AWARD We O are O grateful O for O LC−MS/HRMS O support O provided O by O Dr. O Brandie O Ehrmann O and O Diane O E. O Weatherspoon O in O the O Mass O Spectrometry O Core O Laboratory O at O the O University O of O North O Carolina O at O Chapel O Hill O The O core O is O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG under O grant O no. O CHE-1726291 B-AWARD The O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21805218 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG 2018CFB348 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG WUT O 2018III023 O This O study O was O supported O by O the O Sao B-ORG Paulo I-ORG Research I-ORG Foundation I-ORG FAPESP O through O the O grant O numbers O 2015/12944-9 B-AWARD and O 2020/14786-0 B-AWARD to O A.L O 2020/02469-0 B-AWARD to O Y.F O and O 2020/11182-6 B-AWARD to O R.S.M O A.L O is O also O supported O by O Fundo B-ORG Especial I-ORG de I-ORG Saúde I-ORG para I-ORG Imunização I-ORG em I-ORG Massa I-ORG e I-ORG Controle I-ORG de I-ORG Doenças I-ORG FESIMA I-ORG CAF I-ORG Nº O 001/2021 B-AWARD and O 060/2021 B-AWARD A.C.d.C O is O supported O by O a O scholarship O from O Hospital B-ORG das I-ORG Clínicas I-ORG Faculty I-ORG of I-ORG Medicine I-ORG University I-ORG of I-ORG São I-ORG Paulo I-ORG HCFMUSP O with O funds O donated O by O NUBANK O under O the O HCCOMVIDA B-AWARD scheme O This O study O was O financially O supported O by O the O Research B-ORG Foundation I-ORG of I-ORG Education I-ORG Bureau I-ORG of I-ORG Hunan I-ORG Province I-ORG China I-ORG Grant O No. O 20C0938 B-AWARD the B-ORG science I-ORG and I-ORG technology I-ORG innovation I-ORG Program I-ORG of I-ORG Hunan I-ORG Province I-ORG Grant O No. O 2021RC2082 B-AWARD the O Key B-ORG project I-ORG of I-ORG Hunan I-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG Grant O No. O 22A0155 B-AWARD The B-ORG Forestry I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholarship I-ORG Grant O No. O XLKJ202205 B-AWARD the O Open B-ORG Project I-ORG of I-ORG Horticulture I-ORG Discipline I-ORG of I-ORG Hunan I-ORG Agricultural I-ORG University I-ORG Grant O No. O 2021YYXK001 B-AWARD the O National B-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Training I-ORG Program I-ORG for I-ORG College I-ORG Students I-ORG Grant O No. O 202112653017X B-AWARD and O the O Innovation B-ORG and I-ORG Entrepreneurship I-ORG Training I-ORG Program I-ORG of I-ORG Hunan I-ORG Province I-ORG for I-ORG College I-ORG Students I-ORG Grant O No. O 201941937227 B-AWARD This O study O was O financially O supported O by O The O Ta-Tung O Kidney O Foundation O Taiwan O National B-ORG Science I-ORG Council I-ORG grant O NSC O 96-2314-B-002-164 O NSC O 96-2314-B-002-033-MY3 O NSC O 97-2314-B-002-155-MY2 O NSC O 98-2314-B-002-155-MY4 O 101-2314-B-002-085-MY3 B-AWARD 102-2314-B-002-140-MY2 I-AWARD 104-2314-B-002-125-MY3 O NTUH B-ORG 106-FTN20 O 106-P02 I-AWARD UN106-014 I-AWARD 106-S3582 I-AWARD 105-P05 I-AWARD VN105-04 I-AWARD 105-S3061 I-AWARD VN104-07 I-AWARD 104-S2718 O and O NTUH O 098-001177 O NTUH O 100-001667 O This O study O was O also O supported O by O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG MOST O of O the O Re-public O of O China O Taiwan O grant O number O MOST B-AWARD 106-2321-B-182-002 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O Swedish B-ORG Research I-ORG Council I-ORG 2016-01381 O MC, O 65X-03522-43-3 B-AWARD AEGP O the O Swedish B-ORG Heart I-ORG and I-ORG Lung I-ORG Foundation I-ORG 20140448 O MC, O 20170124 B-AWARD MC O by O Research O Funds O from O the O Karolinska B-ORG Institutet I-ORG 2-560/2015 O MC O and O Her O Highness O The O Crown O Princess O Lovisa’s O Fund O for O Scientific O Research O The O study O was O supported O by O grants O from O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III I-ORG FEDER I-ORG and I-ORG Next I-ORG Generation I-ORG UE I-ORG PI21/00174 O O PMP21/00052 B-AWARD Cifuentes O R O has O a O PFIS O contract O de O la O Morena-Barrio O ME O has O a O Ramon O y O Cajal O RYC2021-031000-I O from O Ministerio B-ORG de I-ORG Ciencia I-ORG e I-ORG Innovación O Bravo-Pérez O C O has O a O Juan B-ORG Rodés I-ORG fellowship I-ORG JR22/00041 O de O la O Morena-Barrio O B O has O a O postdoctoral O contract O from O CIBERER O P O Garrido-Rodríguez O has O a O predoctoral O contract O from O CIBERER O This O research O was O funded O by O National O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 31961143010 O 31970010 B-AWARD Beijing O Innovation I-ORG Consortium I-ORG of I-ORG Agriculture I-ORG Research I-ORG System O grant O number O BAIC03-01 O and O CAS O Engineering I-ORG Laboratory I-ORG for I-ORG Advanced I-ORG Microbial I-ORG Technology I-ORG of I-ORG Agriculture O grant O number O KFJ-PTXM-016 O This O project O is O supported O by O NSFC B-ORG 31571332 O 91440105 B-AWARD Guangdong B-ORG Innovation I-ORG Research I-ORG Team I-ORG Fund I-ORG 2014ZT05S078 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 009339 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG SZU I-ORG 827-000191 O National B-ORG Institutes I-ORG of I-ORG Health I-ORG GM061146 O and O Gordon B-ORG and I-ORG Betty I-ORG Moore I-ORG Foundation I-ORG GBMF3046 O This O study O was O supported O by O the O National B-ORG Cancer I-ORG Institute I-ORG P30CA177558 O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG P20GM121327 O National B-ORG Institutes I-ORG of I-ORG Health I-ORG DP7OD020317 O U.S B-ORG Department I-ORG of I-ORG Labor I-ORG OD-23804-12-75-4-11 O and O National O Institute O of O General O Medical O Sciences O R01GM140282 O This O work O was O supported O by O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O grant O funded O by O the O Korea O government O MSIT O No. O NRF-2018R1C1B6005095 B-AWARD the O Center O for O Women O In O Science O Engineering O and O Technology O WISET O grant O under O the O Program O for O Returners O into O R&D O No. O WISET-2018-803 O the O National B-ORG Research I-ORG Council I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG No. O CAP-18-02-KRIBB B-AWARD and O the O Korea B-ORG Research I-ORG Institute I-ORG of I-ORG Bioscience I-ORG and I-ORG Biotechnology I-ORG KRIBB O Research B-AWARD Initiative I-AWARD Program I-AWARD This O work O was O supported O by O project O RTI2018-094907-B-I00 B-AWARD from O the O Ministerio B-ORG de I-ORG Ciencia I-ORG Innovación I-ORG y I-ORG Universidades I-ORG MCIU O Madrid O Spain O project O FEI16/54 B-AWARD from O the O Universidad B-ORG Complutense I-ORG de I-ORG Madrid I-ORG UCM O and O project O PR75/18–21627 B-AWARD from O Santander/UCM B-ORG Javier O Feito O was O supported O by O a O FEI16/54 O contract O from O UCM O and O held O a O predoctoral O contract O from O the O UCM O Carlos O Araújo O and O Sara O Arbulu O held O a O FEI16/54 O contract O from O the O UCM O This O research O was O funded O by O the O Swedish B-ORG Cancer I-ORG Society I-ORG Cancerfonden O grant O numbers O 20-0815 B-AWARD PjF I-AWARD and O 20 B-AWARD 0814 I-AWARD UsF O the O Swedish B-ORG Research I-ORG Council I-ORG Vetenskapsrådet O grant O numbers O 2019-00986 B-AWARD and O 2022-00556 B-AWARD and O the O Ministry B-ORG of I-ORG Health I-ORG and I-ORG Higher I-ORG Education I-ORG of I-ORG the I-ORG Russian I-ORG Federation I-ORG grant O number O 075-15-2022-1103 B-AWARD This O research O was O funded O by O the O Science B-ORG and I-ORG Technology I-ORG Research I-ORG Projects I-ORG in I-ORG Universities I-ORG in I-ORG Hebei I-ORG Province I-ORG grant O QN2022019 B-AWARD by O the O PhD B-ORG fund I-ORG of I-ORG Hebei I-ORG University I-ORG of I-ORG Chinese I-ORG Medicine I-ORG grant O BSZ2021019 B-AWARD and O by O the O Hebei B-ORG technological I-ORG innovation I-ORG center I-ORG of I-ORG chiral I-ORG medicine I-ORG grant O ZXJJ20210102 B-AWARD This O study O was O funded O by O National B-ORG Nonprofit I-ORG Institute I-ORG Research I-ORG Grant I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG No.2014-30 O Funder O ZYR,http://www.iarrp.cn/sites/IARRP O the O Special B-ORG Fund I-ORG for I-ORG Agro-scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG No.201403019 O Funder O GQH,http://www.moa.gov.cn O National B-ORG Key I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No.2013BAD05B04F02 O Funder O ZYR,http://www.most.gov.cn O and O the O Major B-ORG State I-ORG Basic I-ORG Research I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No.2012CB417104 O Funder O ZYR,http://www.most.gov.cn O ZYR O and O GQH O designed O the O study O and O helped O write O the O manuscript O ZYR O also O contributed O to O analyzing O the O data O and O providing O reagents/materials/analysis O tools O This O work O was O partially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 81627805 O 61805102 O Shenzhen B-ORG Basic I-ORG Research I-ORG Project I-ORG JCYJ20160329150236426 O JCYJ20170413140519030 O Research O Grants O Council O of O the O Hong O Kong O Special O Administrative O Region O 21205016 O 11215817 O 11101618 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 21618319 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81802471 B-AWARD 81872502 B-AWARD 81972758 B-AWARD 31870805 B-AWARD Science B-ORG Foundation I-ORG of I-ORG Peking I-ORG University I-ORG Cancer I-ORG Hospital I-ORG No. O 202207 B-AWARD Hygiene B-ORG and I-ORG Health I-ORG Development I-ORG Scientific I-ORG Research I-ORG Fostering I-ORG Plan I-ORG of I-ORG Haidian I-ORG District I-ORG Beijing I-ORG HP2022-19-503002 O and O Beijing B-ORG Hospitals I-ORG Authority I-ORG Youth I-ORG Programme I-ORG QML20211103 O This O work O is O supported O by O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Key I-ORG Project I-ORG on I-ORG Major I-ORG Infectious I-ORG Diseases I-ORG 2017ZX10303401 O BWS17J034 O for O analysis O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 31170884 B-AWARD for O designing O the O study O the O Science B-ORG Fund I-ORG of I-ORG Jiangsu I-ORG Province I-ORG China I-ORG No. O BE2018617 B-AWARD for O interpretation O the O study O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 82273373 B-AWARD 81802548 B-AWARD 81860451 B-AWARD Yunnan B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O No. O 202001AW070001 B-AWARD 202201AY070001-045 B-AWARD 202101AY070001-014 B-AWARD Yunnan B-ORG Health I-ORG Training I-ORG Project I-ORG of I-ORG High-Level I-ORG Talents I-ORG for O P.G O Grant O No. O H2018070 B-AWARD Yunnan B-ORG Chronic I-ORG Kidney I-ORG Disease I-ORG Clinical I-ORG Medical I-ORG Research I-ORG Center I-ORG Project I-ORG Grant O No. O 202102AA100060 B-AWARD Provincial B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Yunnan-Kunming I-ORG Medical I-ORG University I-ORG Joint I-ORG Foundation I-ORG Grant O No. O 2019FE001-136 B-AWARD Funding O for O young O doctors O for O P.G O from O the O 1st B-ORG Affiliated I-ORG Hospital I-ORG of I-ORG Kunming I-ORG Medical I-ORG University I-ORG Grant O No. O 2017BS016 B-AWARD This O work O was O supported O by O Science O and O Technology O Innovation O Fund O of O Shanxi B-ORG Agricultural I-ORG University I-ORG No. O 2017YJ05 O Outstanding O Doctor O Award O of O Shanxi B-ORG Province I-ORG No. O SXYBKY201713 O and O University O Science O and O Technology O Innovation O Project O of O Department B-ORG of I-ORG Education I-ORG of I-ORG Shanxi I-ORG Province I-ORG No. O 2020L0158 O This O work O was O financially O supported O by O the O Yunnan B-ORG Fundamental I-ORG Research I-ORG Projects I-ORG grant O NO. O 202101AT070057 B-AWARD Yunnan B-ORG Major I-ORG Science I-ORG and I-ORG Technology I-ORG Special I-ORG Plan O Development O and O Application O of O Key O Technologies O for O Efficient O Production O and O Utilization O of O Swine O and O Chicken O Feed O in O Yunnan O Plateau O grant O NO. O 202202AE090024 B-AWARD and O Innovation B-ORG Guidance I-ORG and I-ORG Technological I-ORG Enterprise I-ORG Cultivation I-ORG Project I-ORG in I-ORG Yunnan I-ORG Province O Yunnan O Science O and O Technology O Mission O Project O grant O NO. O 2021104BI090017 B-AWARD This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81471690 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG for I-ORG Young I-ORG Scientists I-ORG 81701734 O Science B-ORG and I-ORG Technology I-ORG Plan I-ORG of I-ORG Jiangsu I-ORG Province I-ORG I-ORG standardization I-ORG of I-ORG diagnosis I-ORG and I-ORG treatment I-ORG of I-ORG key I-ORG diseases I-ORG project I-ORG BE2015635 O None O of O these O agencies O were O involved O in O designing O analyzing O or O interpreting O the O study O results O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81473538 B-AWARD 81773837 B-AWARD 81873189 B-AWARD Six B-ORG Talent I-ORG Peaks I-ORG Project I-ORG in I-ORG Jiangsu I-ORG Province I-ORG No. O YY-026 B-AWARD the O Key O R O O D O Program O of O Ningxia O Hui O Autonomous O Region O East-West O Science O and O Technology O Cooperation O No. O 2017BY079 O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-21 O and O Postgraduate O Research O O Practice O Innovation O Program O of O Jiangsu O Province O KYCX19_1249 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81671437 B-AWARD 81771558 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG grant O number O 2020JJ4814 B-AWARD and O the O Postgraduate B-ORG Independent I-ORG Exploration I-ORG and I-ORG Innovation I-ORG Project I-ORG of I-ORG Central I-ORG South I-ORG University I-ORG China I-ORG grant O number O 2020zzts285 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O D.R.W O has O been O supported O by O Cancer B-ORG Research I-ORG UK I-ORG C54019/A27535 O Cancer B-ORG Research I-ORG Institute I-ORG CRI3128 O and O Worldwide B-ORG Cancer I-ORG Research I-ORG 21-0073 O I.D O was O supported O by O a O Medical O Research O Council O IMPACT O iCASE O PhD O Studentship O with O AstraZeneca O B.C.K O was O supported O by O Cancer O Research O UK O SEBSTF-2021\100002 O This O work O was O supported O by O the B-ORG Middle-aged I-ORG Backbone I-ORG Personnel I-ORG Training I-ORG Program I-ORG of I-ORG Shenyang I-ORG Pharmaceutical I-ORG University I-ORG ZQN2016011 O Scientific B-ORG Research I-ORG Fund I-ORG of I-ORG Liaoning I-ORG Provincial I-ORG Education I-ORG Department I-ORG 2020LZD02 O Inter-school B-ORG Cooperation I-ORG Project I-ORG of I-ORG General I-ORG Undergraduate I-ORG Universities I-ORG in I-ORG Liaoning I-ORG Province I-ORG 2020-181 O Project B-ORG of I-ORG Shenyang I-ORG Key I-ORG Laboratory I-ORG of I-ORG Functional I-ORG Drug I-ORG Carrier I-ORG Materials I-ORG Grant O No. O 19-110-4-08 B-AWARD This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81571040 O 81300925 B-AWARD 61501452 B-AWARD National B-ORG and I-ORG Provincial I-ORG Postdoctoral I-ORG Project I-ORG BE179 O 1501076A B-AWARD 6th B-ORG Peak I-ORG Talent I-ORG Project I-ORG WSN-O50 O Key B-ORG Project I-ORG of I-ORG Nanjing I-ORG Health I-ORG Bureau I-ORG ZKX14027 O Key B-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG of I-ORG Jiangsu I-ORG BE2016613 O BE2016010-3 B-AWARD BE2016010-4 B-AWARD BE2016605 B-AWARD BE2017663 B-AWARD Virtual O Reality O Key O Laboratory O of O Intelligent O Interaction O and O Application O Technology O of O Suzhou O Foundation B-ORG of I-ORG Key I-ORG Laboratory I-ORG in I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Project I-ORG of I-ORG Suzhou I-ORG SYG201606 O SZS201609 B-AWARD SYG201706 B-AWARD SYG201707 B-AWARD SND B-ORG Medical I-ORG Plan I-ORG Project I-ORG 2016Z010 O and O National B-ORG 863 I-ORG Program I-ORG of I-ORG China I-ORG 2015AA020514 O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31530079 O to O GFZ O and O 31572620 B-AWARD to O LL, O in O oyster O cultivation O sample O collection O and O experiments O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG “Western I-ORG Pacific I-ORG Ocean I-ORG System I-ORG Structure I-ORG Dynamics I-ORG and I-ORG Consequences” I-ORG XDA586 O 11020305 O in O data O analysis O and O interpretation O and O the O Earmarked B-ORG Fund I-ORG for I-ORG Modern I-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG CARS-49 O in O manuscript O drafting O and O publication O This O study O was O supported O partially O by O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Taiwan I-ORG MOST-104-2314-B-002-109-MY3 O the O Ministry B-ORG of I-ORG Health I-ORG and I-ORG Welfare O Taiwan O MOHW106-TDU-B-211-113002 O and O the O National B-ORG Taiwan I-ORG University I-ORG Hospital I-ORG NTUH104 O M2926 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31971902 O 31771830 B-AWARD 31701335 B-AWARD the O “111” B-ORG Project I-ORG B12006 O and O National B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0100500 O Thanks O to O the O China O Scholarship O Council O CSC O for O its O support O Authors O acknowledge O the O funding O from O Stiftelsen B-ORG Längmanska I-ORG Kulturfonden O No. O BA18-0708 B-AWARD and O Adlerbertska O Forskningsstiftelsen O Sweden O No. O 09/2017 O The O authors O also O acknowledge O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo I-ORG FAPESP O No. O 12/24574-3 B-AWARD and O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG CAPES O No. O 99999.007057/2015-06 B-AWARD and O No. O 99999.006332/2015-03 B-AWARD This O study O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81901823 O 81771810 B-AWARD 61571343 B-AWARD 61671339 B-AWARD 61432014 B-AWARD and O 61772402 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0100300 O the O National B-ORG 630 I-ORG High-Level I-ORG Talents I-ORG Special I-ORG Support I-ORG Program I-ORG of I-ORG China I-ORG CS31117200001 O the O Project B-ORG Funded I-ORG by I-ORG China I-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2019M653659 B-AWARD and O the O Natural B-ORG Science I-ORG Basic I-ORG Research I-ORG Plan I-ORG in I-ORG Shaanxi I-ORG Province I-ORG of I-ORG China I-ORG No. O 2019JQ-198 B-AWARD The O authors O have O no O competing O interest O related O to O the O study O This O research O was O funded O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31672337 O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG KYZ201405 O the B-ORG Australian I-ORG Research I-ORG Council I-ORG DP120100240 O to O RS) O and O Australia-China B-ORG Science I-ORG I-ORG Research I-ORG Fund I-ORG ACSRF00980 O to O RS O Q.F O is O grateful O to O the O University O of O Aberdeen O Elphinstone O Scholarship O and O Scottish O Funding O Council/ScotCHEM O for O financial O support O through O the O PEER/PERCE O Funding O FM O thanks O the B-ORG University I-ORG of I-ORG the I-ORG Philippines I-ORG for O the B-AWARD Faculty I-AWARD Reps I-AWARD and I-AWARD Staff I-AWARD Development I-AWARD Program I-AWARD FRAS I-AWARD DP) I-AWARD for I-AWARD the I-AWARD PhD I-AWARD grant I-AWARD fellowship O HD O and O KK O thank O the O financial O supports O of O Leverhulme B-ORG Trust-Royal O Society O Africa O award O AA090088 O and O the O jointly O funded O UK O Medical B-ORG Research I-ORG Council-UK O Department O for O International O Development O MRC/DFID O Concordat O agreement O African O Research O Leaders O Award O MR/S00520X/1 O This O project O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21576160 O Science B-ORG and I-ORG Technology I-ORG Research I-ORG Project I-ORG of I-ORG Shaanxi I-ORG Province I-ORG Academy I-ORG of I-ORG Sciences I-ORG 2018nk-01 O 2018k-09 B-AWARD Shaanxi B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 2017NY-192 O 2018NY-152 B-AWARD 2019NY-209 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O funding O from O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG Central I-ORG Non-profit I-ORG Scientific I-ORG Institution I-ORG Y2017XM04 O the O Elite B-ORG Young I-ORG Scientists I-ORG Program I-ORG of I-ORG CAAS I-ORG and I-ORG Shenzhen I-ORG science I-ORG and I-ORG technology I-ORG research I-ORG funding I-ORG JSGG20160429104101251 O and O Guangxi B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2016GXNSFBA380221 O This O work O was O supported O by O Russian B-ORG Foundation I-ORG for I-ORG Basic I-ORG Research I-ORG and I-ORG Moscow I-ORG city I-ORG Government I-ORG according O to O the O project O No O 21-33-70003 B-AWARD Financial O support O from O the O CNRS O the O Conseil B-ORG Régional I-ORG de I-ORG Bourgogne I-ORG PARI O IME I-AWARD SMT8 I-AWARD and I-AWARD PARI I-AWARD II I-AWARD CDEA I-AWARD programs O and O the O European B-ORG Regional I-ORG Development I-ORG Fund I-ORG FEDER O is O also O acknowledged O E.V.E O is O grateful O to O the O French B-ORG government I-ORG and O French O embassy O in O Russia O for O the O SSTE-2016 B-AWARD grant O This O work O was O carried O out O in O the O frame O of O the O International O Associated O French–Russian O Laboratory O of O Macrocycle O Systems O and O Related O Materials O LIA O LAMREM O of O CNRS O and O RAS O This O project O was O supported O by O the O US O National O Institutes O of O Health O NIH O and O National B-ORG Institute I-ORG on I-ORG Drug I-ORG Abuse I-ORG NIDA O grants O P30DA027828 B-AWARD PI: O CHB O R01DA038466 B-AWARD PI: O GAA O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health I-ORG NIMH O grants O R01MH072961 B-AWARD and O R01MH092950 B-AWARD PI: O GAA O NIMH O and O NIDA O grant O R01DA035145 O BM O Agency B-ORG for I-ORG Healthcare I-ORG Research I-ORG and I-ORG Quality I-ORG grant O F32HS024192 B-AWARD PI: O MS) O and O National O Institute O on O Minority O Health O and O Health O Disparities O NIMHD O grant O U01MD011281 O PI: O BM O We O also O acknowledge O the O NIH O supported O Third O Coast O Center O for O AIDS O Research O for O creating O a O supportive O environment O for O HIV/AIDS O research O P30AI117943 O This O study O was O supported O by O research O grants O of O the O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG MOP-111012 O to O N.P O and O Cystic B-ORG Fibrosis I-ORG Canada I-ORG Discovery O Grant O 3180 B-AWARD to O N.P O H.J.H O is O a O recipient O of O an O Ontario O Graduate O Scholarship O OGS O Ontario O Student O Opportunity O Trust O Fund/Restracomp O studentship O of O SickKids O and O The O University B-ORG of I-ORG Toronto I-ORG Fellowships O UTF O M.A.K O is O a O recipient O of O a O Mitacs O Elevate O Postdoctoral O Fellowship O This O study O was O supported O by O the O Research B-ORG Program I-ORG for I-ORG Key I-ORG Technologies I-ORG of I-ORG Sponge I-ORG City I-ORG Construction I-ORG and I-ORG Management I-ORG in I-ORG Guyuan I-ORG City I-ORG No. O SCHM-2018 B-AWARD to O Miansong O Huang O the O China B-ORG Major I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG for I-ORG Water I-ORG Pollution I-ORG Control I-ORG and I-ORG Treatment I-ORG No. O 2017ZX07101003 B-AWARD to O Jian O Liu O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 41601333 B-AWARD to O Ruilian O Sun O Miansong O Huang O is O employed O by O a O commercial O company O Beijing O Capital O Co O Ltd O and O the O funder O provided O support O in O the O form O of O salaries O for O Miansong O Huang O but O did O not O have O any O additional O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O specific O roles O of O the O author O are O articulated O in O the O “author O contributions” O section O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 21571101 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG in O China O Grant O No. O BK20161543 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG of I-ORG China I-ORG Grant O No. O 15KJB430016 B-AWARD This O work O was O supported O by O Program B-ORG of I-ORG Shanghai I-ORG Academic/Technology I-ORG Research I-ORG Leader I-ORG Grant O Number O 17XD1403500 B-AWARD Innovation B-ORG Project I-ORG for I-ORG Undergraduates I-ORG of I-ORG Shanghai I-ORG University I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG 2019SHUTCM182 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Number O 81773927 B-AWARD 81573814 B-AWARD and O Xinglin B-ORG Young I-ORG Scholar I-ORG 2017.10-2020.9 O to I-AWARD Jiaye I-AWARD Jiang O At O the O time O that O the O study O was O conducted O A.J O Farias O was O a O postdoctoral O fellow O supported O by O a O University O of O Texas O Health O Science O Center O at O Houston O School O of O Public O Health’s O Cancer O Education O and O Career O Development O Program O grant O from O the O National B-ORG Cancer I-ORG Institute I-ORG R25-CA57712 O which O funded O the O study O design O of O the O study O analysis O interpretation O of O the O data O and O writing O the O manuscript O This O study O was O also O supported O in O part O by O grants O to O X.L O Du O from O the O Agency B-ORG for I-ORG Healthcare I-ORG Research I-ORG and I-ORG Quality I-ORG R01-HS018956 O and O the O Cancer B-ORG Prevention I-ORG and I-ORG Research I-ORG Institute I-ORG of I-ORG Texas I-ORG RP130051 O This O work O was O supported O by O the O Open B-ORG Topic I-ORG of I-ORG Dental I-ORG and I-ORG Jaw I-ORG Disease I-ORG Clinical I-ORG Medical I-ORG Research I-ORG Center I-ORG of I-ORG Shaanxi I-ORG province I-ORG grant#2017YHJB05 O LN O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shaanxi I-ORG province I-ORG grant O 2017SF-106 O FW O the O program B-ORG for I-ORG young I-ORG researcher I-ORG grant I-ORG of I-ORG Xi’an I-ORG Jiao I-ORG Tong I-ORG University I-ORG School I-ORG and I-ORG Hospital I-ORG of I-ORG Stomatology I-ORG grant O 2016-04 O FW O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O 81500840 O RRL O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O No.61575019 O No.11474018 O No.61775013 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG under O Grant O No.2016YFB0401302 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG under O Grant O No.2016JBM066 O This O research O was O funded O by O the O Key B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Henan I-ORG Province I-ORG under O grants O 212102110234 B-AWARD 222102320080 B-AWARD and O 232102111124 B-AWARD the O Colleges B-ORG and I-ORG Universities I-ORG Key I-ORG Research I-ORG Project I-ORG of I-ORG Henan I-ORG Province I-ORG under O grant O 22A210013 B-AWARD and O the O Major B-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG in I-ORG Xinxiang I-ORG City I-ORG Henan I-ORG Province I-ORG under O grant O 21ZD003 B-AWARD This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31470675 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O BLX2013026 B-AWARD and O the O National B-ORG Training I-ORG Program I-ORG of I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG for I-ORG Undergraduates I-ORG No. O 201510022069 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O the O Wellcome B-ORG Trust I-ORG K.C O Grant O number O 204615/Z/16/Z B-AWARD the O National B-ORG Centre I-ORG for I-ORG the I-ORG Replacement I-ORG Refinement I-ORG and I-ORG Reduction I-ORG of I-ORG Animals I-ORG in I-ORG Research I-ORG J.L.S O and O J.M O Grant O number O NC/W001136/1 B-AWARD and O the O Spanish B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Innovation I-ORG A.C O Grant O number O PID2019-1946GB-100 B-AWARD AC O is O a O Serra O Húnter O fellow O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 60907003 B-AWARD 61805278 O 11374251 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation O grant O number O 2018M633704 B-AWARD the O Foundation O of O NUDT O grant O number O JC13-02-13 O ZK17-03-01 O the O Hunan O Provincial O Natural O Science O Foundation O of O China O grant O number O 2019JJ40280 O and O 13JJ3001 O Research O and O Development O Plan O of O key O areas O in O Hunan O Province O in O 2019 O grant O number O 2019GK2101 O and O the O Program B-ORG for I-ORG New I-ORG Century I-ORG Excellent I-ORG Talents I-ORG in I-ORG University O grant O number O NCET-12-0142 B-AWARD This O research O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31571702 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG KYZ201711 O and O the O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O program I-AWARD 809001 O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31620103913 O and O U2003118 B-AWARD Natural B-ORG Science I-ORG Basic I-ORG Research I-ORG Plan I-ORG in I-ORG Shaanxi I-ORG Province I-ORG of I-ORG China I-ORG 2020JZ-12 O National B-ORG “111 I-ORG plan” I-ORG BP0719026 O and O Shaanxi B-ORG Innovation I-ORG Team I-ORG Project I-ORG 2018TD-004 O We O appreciate O the O financial O support O of O the O German B-ORG Research I-ORG Foundation I-ORG DFG O graduate O school O welisa O No. O 1505/2 B-AWARD and O the O DFG O ELAINE O No. O 1270/1 B-AWARD SS O is O grateful O to O the O KarriereWegeMentoring-Programme O of O the O University O Medical O Center O Rostock O European O Social I-ORG Fund I-ORG for I-ORG Germany I-ORG and O the O state O of O Mecklenburg-Vorpommern O ESF/14-SM-A41-0005/15 B-AWARD HR O is O currently O supported O by O the O German B-ORG Ministry I-ORG of I-ORG Education I-ORG and I-ORG Research I-ORG BMBF O FKZ O 13GW0109D B-AWARD The O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 12064036 B-AWARD No. O 12204324 B-AWARD the O Program B-ORG for I-ORG Changjiang I-ORG Scholars I-ORG and I-ORG Innovative I-ORG Research I-ORG Team I-ORG in I-ORG University I-ORG No. O IRT_15R46 B-AWARD Yangtze B-ORG River I-ORG scholar I-ORG research I-ORG project I-ORG of I-ORG Shihezi I-ORG University I-ORG No. O CJXZ201601 B-AWARD Shihezi B-ORG University I-ORG Young I-ORG Innovative I-ORG Talents I-ORG Cultivation I-ORG Program I-ORG No. O CXPY202114 B-AWARD High-level B-ORG talent I-ORG scientific I-ORG research I-ORG start-up I-ORG project I-ORG No. O RCZK202008 B-AWARD This O work O was O supported O by O grants O from O UK B-ORG Research I-ORG and I-ORG Innovation I-ORG MR/T020504/1 B-AWARD to O LFS O the O Integrated B-ORG Biological I-ORG Imaging I-ORG Network I-ORG IBIN4LS O to O LFS O Yorkshire’s O Brain O Tumour O Charity O and O OSCARs O Paediatric O Brain O Tumour O Charity O Joint O Infrastructure O funding O to O LFS O the O British O Neuropathology O Society O Small O Grant O Award O to O SA O and O Health O Data O Research O UK, O an O initiative O funded O by O UK O Research O and O Innovation O Department O of O Health O and O Social O Care O England O and O the O devolved O administrations O and O leading O medical O research O charities O Work O in O the O Ihrie O lab O is O supported O by O the O US O National B-ORG Institutes I-ORG of I-ORG Health I-ORG R01NS118580 O and O a O supplement O to O U54CA217450 B-AWARD to O RAI O the O Ben O O Catherine O Ivy O Foundation O RAI O and O a O gift O from O the O Michael O David O Greene O Brain O Cancer O Fund O at O the O Vanderbilt–Ingram O Cancer O Center O RAI O This O study O was O supported O by O the O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG No. O 2017-I2M-1-009 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 3332018136 B-AWARD Peking B-ORG Union I-ORG Medical I-ORG College I-ORG Graduate I-ORG Student I-ORG Innovation I-ORG Fund I-ORG 2017-1002-2-25 O and O Young O Scientists O Fund O of O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81702933 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61332013 B-AWARD No. O 61672161 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFB1001400 B-AWARD and O the O China B-ORG Scholarship I-ORG Council I-ORG No. O 201706290110 B-AWARD This O work O was O supported O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG grant O no. O 2018YFB1305400 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O nos O 61673246 B-AWARD and O 81301294 B-AWARD the O key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shandong I-ORG province I-ORG grant O no. O 2016GSF201168 B-AWARD and O the O Research B-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Jinan I-ORG grant O no. O 201907064 B-AWARD This O work O was O supported O by O BBSRC/DBT B-ORG grant O BB/L004690/1 O to O P.M O and O by O the O Government B-ORG of I-ORG India I-ORG grant O BT/IN/Indo-UK/FADH/46/SM/2013 O to O S.M O S.Y O received O support O from O an O ICAR B-ORG International I-ORG Fellowship I-ORG awarded O by O Government O of O India O Work O at O MRC-CVR O UK O was O supported O by O Wellcome O Trust O grant O 092806/B/10/Z O Interactions O between O co-authors O were O also O supported O by O the O EU B-AWARD H2020 I-AWARD PALE-Blu I-AWARD grant O project O No: I-AWARD 727393-2 O This O study O was O supported O by O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 O Program O grant O number O 2012CB955504 B-AWARD the O National B-ORG Major I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG grant O number O 2016YFC1200802 B-AWARD and O the O China B-ORG Prosperity I-ORG Strategic I-ORG Programme I-ORG Fund I-ORG SPF O 2015–16 O Project O Code O 15LCI1 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Key O Research O and O Development O Program O of O Zhejiang O Province O grant O no. O 2018C02012 O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O no. O 2017YFD0400800 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 31501474 B-AWARD the O Natural O Science O Foundation O of O Zhejiang O Province O grant O no. O LY15C200007 O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities O Fujian O Province O “2011 O Collaborative O Innovation O Center” O of O Chinese O Oolong O Tea O Project O Fujian O Educational O Department O 2015 O No.75 O and O the O 2016 O Project O of O Funding O Municipal O Project O RF O and O DN O acknowledge O collaborative O funding O from O the O Agence B-ORG Nationale I-ORG de I-ORG la I-ORG Recherche I-ORG project O “IMP-REGULOME,” O ANR-18-CE12-0022-02 B-AWARD RF O acknowledges O funding O from O the O Fondation B-ORG pour I-ORG la I-ORG Recherche I-ORG Médicale I-ORG FRM O DEQ20150331703 B-AWARD the O ANR O ANR-13-BSV2-0014 O and O Labex O “Epigenmed,” O and O the O ANR O “Investissement O d’avenir” O programme O ANR-10-LABX-12-01 O DN O acknowledges O funding O from O the O Fondation B-ORG ARC I-ORG PJA20141201727 O the O FRM O AJE20140630069 O the O ANR O ANR-14-ACHN-0009-01 O and O the O Fondation B-ORG Bettencourt-Schueller O The O funding O bodies O had O no O role O in O the O design O of O the O study O the O collection O analysis O and O interpretation O of O the O data O and O in O the O writing O the O manuscript O This O work O was O supported O by O grants O from O the B-ORG Foundation I-ORG of I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2014C33153 O the B-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Health I-ORG Department I-ORG 2014KYB218 O and I-AWARD 2017KY717 O and O the B-ORG Foundation I-ORG of I-ORG Taizhou I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG 14SF05,1301KY36 O and I-AWARD 1201KY22 O This O work O was O supported O by O the O Project O for O the O Technical B-ORG System I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicinal I-ORG Material I-ORG Industry I-ORG in I-ORG Henan I-ORG Province I-ORG YuCaiKe O 2022 I-AWARD No.24 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U1804233 O 31870093 B-AWARD 31800096 B-AWARD 31872092 B-AWARD 31872157 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Henan I-ORG Province I-ORG 182300410082 O the O Key B-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Henan I-ORG Province I-ORG 212102110475 O the O Henan B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG Joint I-ORG Fund I-ORG 222103810057 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD1000800 O the O Innovative B-ORG Research I-ORG Team I-ORG in I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG the I-ORG University I-ORG of I-ORG Henan I-ORG Province I-ORG 23IRTSTHN024 O and O Student B-ORG research I-ORG training I-ORG program I-ORG SRTP I-ORG project I-ORG of I-ORG Henan I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2022509 O 2022475 B-AWARD This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 11771152 B-AWARD 11901203 B-AWARD 11971176 B-AWARD Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG 2019B151502062 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG funded I-ORG project I-ORG No. O 2019M662895 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2019MS111 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O We O acknowledge O financial O support O from O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2018YFD0700303 B-AWARD Jiangsu B-ORG Province I-ORG Key I-ORG Laboratory I-ORG Project I-ORG of I-ORG Advanced I-ORG Food I-ORG Manufacturing I-ORG Equipment I-ORG and I-ORG Technology I-ORG No. O FMZ202003 B-AWARD and O the O National B-ORG First-Class I-ORG Discipline I-ORG Program I-ORG of I-ORG Food I-ORG Science I-ORG and I-ORG Technology I-ORG No. O JUFSTR20180205 B-AWARD all O of O which O enabled O us O to O carry O out O this O study O This O work O was O supported O by O grants O from O the B-ORG national I-ORG key I-ORG R&D I-ORG program I-ORG of I-ORG China I-ORG 2018YFC0116800 O 2016YFC0905200 B-AWARD the B-ORG program I-ORG for I-ORG the I-ORG Changjiang I-ORG scholars I-ORG and I-ORG innovative I-ORG research I-ORG team I-ORG IRT13082 O the B-ORG national I-ORG natural I-ORG science I-ORG foundation I-ORG of I-ORG China I-ORG 81800882 O 81630023 B-AWARD 81870698 B-AWARD Beijing B-ORG municipal I-ORG administration I-ORG of I-ORG hospitals’ I-ORG mission I-ORG plan I-ORG SML20150203 O Beijing B-ORG municipal I-ORG administration I-ORG of I-ORG hospitals’ I-ORG Dengfeng I-ORG plan I-ORG DFL20190202 O Beijing B-ORG municipal I-ORG administration I-ORG of I-ORG hospitals I-ORG clinical I-ORG medicine I-ORG development I-ORG of I-ORG special I-ORG funding I-ORG support I-ORG XMLX201816 O and O capital B-ORG health I-ORG development I-ORG foundation I-ORG 2016-1-2052 O This O research O was O funded O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG Grant O No. O 2018YFA0702900 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 51774265 B-AWARD the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG China I-ORG Grant O No. O 2019ZX06004010 B-AWARD Program O of O CAS O Interdisciplinary O Innovation O Team O and O Youth O Innovation O Promotion O Association O CAS O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 82102532 I-AWARD to O NW O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG project I-ORG of I-ORG Xi’an I-ORG 21YXYJ0121 O to O NW O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 2021JM-287 O to O XYM O 2022JM-449 B-AWARD to O NW O This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG of I-ORG China I-ORG Programs I-ORG 81702775 O 81861138015 B-AWARD 31771641 B-AWARD 31961133024 B-AWARD 31601106 B-AWARD 81530043 B-AWARD and O 81571612 B-AWARD grants O from O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFA0107500 O and O 2018YFC1704300 B-AWARD Scientific B-ORG Innovation I-ORG Project I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDA16020403 O Ministry B-ORG of I-ORG Foreign I-ORG Affairs I-ORG and I-ORG International I-ORG Cooperation I-ORG Italy-China I-ORG Science I-ORG and I-ORG Technology I-ORG Cooperation I-ORG PGR00961 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81672991 O and O 81874139 B-AWARD S. O Liu O 81672787 B-AWARD Y. O Tao O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2015CB553903 O Y. O Tao O and O the O Hunan B-ORG Provincial I-ORG Key I-ORG Area I-ORG R&D I-ORG Programmes I-ORG 2019SK2253 O This O work O was O supported O in O parts O by O the O Medical B-ORG Research I-ORG Council I-ORG 95505126 O to O AW, O Royal B-ORG Society I-ORG UF100419 O to O JM O and O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG BB/R000352/1 O to O GEB O and O AW. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81601452 B-AWARD the O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 7174295 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG No. O 2016YFC0902500 B-AWARD This O work O was O supported O by O theEnvironmental O Protection I-ORG Agency(EPA O 2014-CCRP-MS.24),Innovationsfonden B-AWARD Denmark(COMETS O 4106-00033A O andScience O Foundation I-ORG Ireland I-ORG SFI I-ORG MaREI I-ORG Centre(12/RC/2302 O This O study O was O supported O by O the O National B-ORG Science I-ORG Centre I-ORG Poland O under O grant O no. O 2017/25/N/NZ7/01705 B-AWARD A.L O and O T.R O acknowledge O the O financial O support O of O the O Polish B-ORG Ministry I-ORG of I-ORG Science O grant O no. O 0911/SBAD/2207 B-AWARD M.F O acknowledges O the O Polish B-ORG National I-ORG Agency I-ORG for I-ORG Academic I-ORG Exchange I-ORG for O the O Bekker O programme O no O PPN/BEK/2020/1/00357 B-AWARD M.H O is O member O of O the O Center O of O Excellence O “Towards O Personalized O Medicine” O operating O under O the O Excellence O Initiative—Research O University O at O Nicolaus O Copernicus O University O in O Torun O Poland O This O work O has O been O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O No. O 31701415 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O Nos O 2018YFD0100803 B-AWARD and O 2016YFD0100801 B-AWARD and O Chinese B-ORG Universities I-ORG Scientific I-ORG Fund I-ORG grant O No. O 2019TC153 B-AWARD This O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81371367 O 81471256 B-AWARD the O Youth B-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81401013 O and O the B-ORG Key I-ORG Talents I-ORG of I-ORG Young I-ORG Medicine I-ORG in I-ORG Jiangsu I-ORG Province I-ORG QNRC2016696 O QNRC2016692 B-AWARD This O work O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2017YFD0101804 O the O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG CAAS-ASTIP-2013-IVFCAAS O the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 863 O Program I-AWARD 2012AA100101 O the O Key O Projects O in O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Pillar I-ORG Program I-ORG during I-ORG the I-ORG Twelfth I-ORG Five-Year I-ORG Plan I-ORG Period I-ORG 2012BAD02B01 O the O Modern B-ORG Agro-Industry I-ORG Technology I-ORG Research I-ORG System I-ORG CARS-25-B-01 O and O the O Project B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Beijing I-ORG Municipality I-ORG Z141105002314020-1 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O We O would O like O to O thank O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41101254 O the O International B-ORG Partnership I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences O Grant O No. O 161461KYSB20170013 B-AWARD and O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017M623266 O for O funding O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81503327 B-AWARD the B-ORG scientific I-ORG research I-ORG project I-ORG of I-ORG Chinese I-ORG medicine I-ORG management I-ORG of I-ORG Shaanxi I-ORG Province I-ORG China I-ORG ZYMS008 O and O the B-ORG key I-ORG research I-ORG and I-ORG development I-ORG plan I-ORG of I-ORG Shaanxi I-ORG Province I-ORG China I-ORG 2017SF-136 O This O work O was O supported O by O the O grant O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81803778 B-AWARD the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. O 2018C0302 B-AWARD the O Public B-ORG Welfare I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG Nos O 2016C37101 B-AWARD 2017C33216 I-AWARD and I-AWARD LGF18H160035 O the O Science B-ORG and I-ORG Technology I-ORG Development I-ORG Project I-ORG of I-ORG Lishui I-ORG City I-ORG Nos O 2016GYX39 B-AWARD 2017ZDXK07 I-AWARD and I-AWARD 2017ZDXK09 O and O High-level B-ORG Talent I-ORG Project I-ORG of I-ORG Lishui I-ORG City I-ORG Nos O 2016RC22 B-AWARD and I-AWARD 2018RC17 O This O project O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81303278 O the O Provincial B-ORG Scientific I-ORG Research I-ORG Special I-ORG Foundation I-ORG of I-ORG Henan I-ORG University I-ORG of I-ORG Chinese I-ORG Medicine I-ORG 2014KYYWF-QN19 O and O Scientific B-ORG and I-ORG Technologically I-ORG Innovative I-ORG Talents I-ORG of I-ORG Henan I-ORG University I-ORG of I-ORG Chinese I-ORG Medicine I-ORG 2015XCXRC03 O This O study O was O supported O by O the O Project B-ORG of I-ORG the I-ORG NARO I-ORG Bio-oriented I-ORG Technology I-ORG Research I-ORG Advancement I-ORG Institution I-ORG Research O program O on O development O of O innovative O technology O grant O no. O 29018C B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32001842 O and O the O Natural B-ORG Science I-ORG Special I-ORG Special I-ORG Post I-ORG Scientific I-ORG Research I-ORG Fund I-ORG Project I-ORG of I-ORG Guizhou I-ORG University O grant O No. O 2020(12 B-AWARD This O research O was O financially O supported O by O the O Key B-ORG Deployment I-ORG Project I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG ZDRW-ZS-2016-3 O the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2015AA020202 O and O Tianjin B-ORG Key I-ORG Technology I-ORG R&D I-ORG program I-ORG of I-ORG Tianjin I-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG 14ZCZDSY00067 O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 61901483 B-AWARD and O 62061136011 B-AWARD the O Research B-ORG Fund I-ORG Program I-ORG of I-ORG the I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG High-Performance I-ORG Computing I-ORG Grant O No. O 202001-02 B-AWARD and O the O Autonomous B-ORG Project I-ORG of I-ORG the I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG High-Performance I-ORG Computing I-ORG Grant O No. O 202101-15 B-AWARD This O study O was O supported O by O the O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81802918 O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG China I-ORG 2018ZX10305409-001-001 O the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2019A1515011565 O 2018A030310007 O the O Science B-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG Bureau I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG 20181273 O and O the O Medical B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangmen I-ORG Central I-ORG Hospital I-ORG J201801 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O National O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 51627805 O Department O of I-ORG Finance I-ORG of I-ORG Jilin I-ORG Province O grant O number O QT10646 O Department O of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Jilin I-ORG Province O grant O number O 20160101138JC O Natural O Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O grant O number O 2018A0303130019 O Department O of I-ORG Education I-ORG of I-ORG Guangdong I-ORG Province O grant O number O 2016KQNCX168 O and O Dongguan O University I-ORG of I-ORG Technology O grant O number O KCYCXPT2016003 O This O study O was O funded O in O part O by O the O Startup B-ORG Foundation I-ORG for I-ORG Advanced I-ORG Talents I-ORG and I-ORG the I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Foundation I-ORG at I-ORG Yangzhou I-ORG University I-ORG 137011856 O H.S O the O Innovative B-ORG Training I-ORG Grant I-ORG of I-ORG College I-ORG Students I-ORG in I-ORG Jiangsu I-ORG Province I-ORG 202111117097Y O Y.G O and O H.S O the O Distinguished B-ORG Doctoral I-ORG Program I-ORG of I-ORG Green I-ORG Yang I-ORG Golden I-ORG Phoenix I-ORG of I-ORG Yangzhou I-ORG City I-ORG 137012751 O 2021 O to O S.Y O and O the O Talent B-ORG Introduction I-ORG Fund I-ORG of I-ORG Yangzhou I-ORG University I-ORG 137012455 O to O S.Y O This O research O was O funded O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 82001918 B-AWARD the O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O numbers O LR23F010003 B-AWARD LTGY23H180015 B-AWARD and O LQ19E050011 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Special I-ORG Project I-ORG of I-ORG the I-ORG Institute I-ORG of I-ORG Wenzhou I-ORG Zhejiang I-ORG University O grant O number O XMGL-KJZX-202203 B-AWARD This O work O was O funded O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 22179108 O the B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Projects I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 2020GXLH-Z-032 O the B-ORG Doctoral I-ORG Re-search I-ORG Start-up I-ORG Fund I-ORG project I-ORG of I-ORG Xi’an I-ORG Polytechnic I-ORG University I-ORG 107020589 O the B-ORG Shaanxi I-ORG Provincial I-ORG High-Level I-ORG Talents I-ORG Introduction I-ORG Project I-ORG Youth O Talent I-AWARD Fund O This O study O was O supported O by O grant O from O the B-ORG Application I-ORG Research I-ORG and I-ORG Demonstration I-ORG I-ORG Promotion I-ORG of I-ORG Hainan I-ORG Province I-ORG No. O ZDXM2014074 O the B-ORG Medical I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. O 2017KYB521 O and O the B-ORG Key I-ORG Project I-ORG of I-ORG Medical I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Hangzhou I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG No. O 2018Z01 O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 51805044 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province O grant O number O 2018JQ5064 B-AWARD and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities O grant O numbers O 300102258202 B-AWARD and O 300102258402 B-AWARD This O research O was O funded O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG 5R01HL089315-11 O YJW O the O American B-ORG Heart I-ORG Association I-ORG 18POST33990223 O HW; O 17POST33410497 B-AWARD MJP O the O National B-ORG Science I-ORG Foundation I-ORG GRFP O DGE-1147470 O ANS O and O LMS O and O the O Thoracic B-ORG Surgery I-ORG Foundation I-ORG Resident O Research I-AWARD Award I-AWARD 2019-2021 O YZ O The O ENVIRONAGE O birth O cohort O is O supported O by O the O European B-ORG Research I-ORG Council I-ORG ERC-2012-StG.310898 O by O the O Flemish B-ORG Scientific I-ORG Fund I-ORG FWO O G.0.733.15.N O and O the O Special O Research O Fund O BOF O of O Hasselt O University O This O work O was O also O supported O by O funding O from O the O US O National B-ORG Institute I-ORG of I-ORG Environmental I-ORG Health I-ORG Sciences I-ORG R21ES022694 O and O R01ES021733 B-AWARD This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 91546101 O 81300750 B-AWARD the B-ORG Outstanding I-ORG Young I-ORG Teacher I-ORG Cultivation I-ORG Projects I-ORG in I-ORG Guangdong I-ORG Province I-ORG YQ2015006 O the B-ORG Guangdong I-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG of I-ORG China I-ORG 2014A030306030 O the B-ORG Youth I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Talents I-ORG Funds I-ORG in I-ORG a I-ORG Special I-ORG Support I-ORG Plan I-ORG for I-ORG High I-ORG Level I-ORG Talents I-ORG in I-ORG Guangdong I-ORG Province I-ORG 2014TQ01R573 O The O sponsors O and O funding O organizations O had O no O role O in O the O design O or O performance O of O this O research O This O work O was O supported O by O National B-ORG Institutes I-ORG of I-ORG Health/National I-ORG Cancer I-ORG Institute I-ORG CA136526 B-AWARD Mayo B-ORG Clinic I-ORG Pancreatic I-ORG SPORE I-ORG P50 B-AWARD CA102701 O and O Mayo B-ORG Clinic I-ORG Center I-ORG for I-ORG Cell I-ORG Signaling I-ORG in I-ORG Gastroenterology I-ORG P30 B-AWARD DK84567 I-AWARD to O MEF-Z O This O work O was O supported O by O grants O from O the O Health O O Medical O Collaborative O Innovation O Project O of O Guangzhou O City O China O No. O 201400000001 O the O Sun B-ORG Yat-sen I-ORG University I-ORG Clinical I-ORG Research I-ORG 5010 I-ORG Program I-ORG No. O 2012011 O the B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Guangzhou I-ORG City I-ORG China I-ORG No. O 14570006 O and O the B-ORG Planned I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2013B020400004 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O grants O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81871675 B-AWARD and O No. O 81430052 B-AWARD and O grant O of O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG MOST O No: O 2018YFA0507300 B-AWARD to O Chuan O Su, O and O the B-ORG grant I-ORG from I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81871676 B-AWARD to O Xiaojun O Chen O and O the O grant O from O National O Natural O Science O Foundation O of O China O No. O 81900562 B-AWARD to O Liyang O Dong O The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG Project I-ORG Funding I-ORG 2018YFD1000607 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31772285 O Foundation B-ORG for I-ORG 100 I-ORG Innovative I-ORG Talents I-ORG of I-ORG Hebei I-ORG Province I-ORG SLRC2019031 O Hebei O Distinguished O Young O Scholar O C201620 O 4145 O and O Hebei O Special O Funds O for O Intellectual O Introduction O and O Talent O Training O A20160 O 02054 O These O funding O bodies O had O no O role O in O the O design O of O the O study O sample O collection O analysis O or O interpretation O of O data O and O in O writing O the O manuscript O This O study O was O funded O by O Chinese B-ORG National I-ORG Major I-ORG Project I-ORG for I-ORG New I-ORG Drug I-ORG Innovation I-ORG 2017ZX09304015 O 2019ZX09201002 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81472752 O 81871739 B-AWARD and O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG CIFMS O 2016-I2M-1-001 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31460499 O the O Science B-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG Gansu I-ORG Province I-ORG 18ZD2NA006 O and O the O Forestry B-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG of I-ORG Gansu I-ORG Province I-ORG 2015kj023 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31560075 O 31460046 B-AWARD 31760047 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Province I-ORG 20161BAB214149 O and O Foundation B-ORG of I-ORG Chinese I-ORG medicine I-ORG research I-ORG of I-ORG health I-ORG and I-ORG family I-ORG planning I-ORG commission I-ORG of I-ORG Jiangxi I-ORG province I-ORG 2017B0700 O This O research O was O supported O by O the O International O Wheat O Yield O Partnership O through O grants O provided O by O the O Grains B-ORG Research I-ORG and I-ORG Development I-ORG Corporation I-ORG US00082 O and O CIMMYT B-ORG IWYP89FP O TNB O was O supported O by O the O Australian B-ORG Research I-ORG Council I-ORG DP150103863 O and O LP130100183 B-AWARD and O the O National B-ORG Science I-ORG Foundation I-ORG Award O 1557906 O This O work O was O supported O by O the O USDA B-ORG National I-ORG Institute I-ORG of I-ORG Food I-ORG and I-ORG Agriculture O Hatch B-AWARD project I-AWARD 1016439 I-AWARD This O study O was O funded O by O grants O from O the O National B-ORG Distinguished I-ORG Young I-ORG Scientists I-ORG Grant I-ORG of I-ORG China I-ORG 81325009 O and O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81270168 O 81530058 B-AWARD FCao O BWS12J037 O Innovation B-ORG Team I-ORG Development I-ORG Grant I-ORG by I-ORG China I-ORG Department I-ORG of I-ORG Education I-ORG IRT1053 O and O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2012CB518101 O The O authors O acknowledge O the O funding O from O the O German B-ORG Research I-ORG Foundation I-ORG DFG O within O the O priority O program O 2171 O Dynamic O wetting O of O flexible O adaptive O and O switchable O surfaces O project O ID: O 422798085 B-AWARD and O under O Germany’s B-ORG Excellence I-ORG Strategy–EXC-2193/1–390951807 O This O work O was O funded O by O the O German B-ORG Federal I-ORG Ministry I-ORG for I-ORG Economic I-ORG Affairs I-ORG and I-ORG Energy I-ORG BMWi O within O the O Central O Innovation O Programme O for O Medium-Sized O Companies O ZIM O funding O code O ZF4052421AP9 B-AWARD CC O acknowledges O the O support O of O the B-ORG SciSIP I-ORG Program I-ORG of I-ORG the I-ORG National I-ORG Science I-ORG Foundation I-ORG Award O 1633286 O the O support O of O Microsoft O Azure O Sponsorship O Data O sourced O from O Dimensions O an O inter-linked O research O information O system O provided O by O Digital O Science O https://www.dimensions.ai O MS O acknowledges O the O support O of O the B-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG the I-ORG Republic I-ORG of I-ORG Korea I-ORG and I-ORG the I-ORG National I-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF-2018S1A3A2075114 O and O partial O support O from O the O Yonsei B-ORG University I-ORG Research O Fund O of O 2019-22-0066 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Norges B-ORG Forskningsråd O 244526 B-AWARD Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico O 479201/2008 B-AWARD 0. O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo O 2007/07805-3 B-AWARD and O 2008/07358-0 B-AWARD The O six O sites O of O the O Breast O Cancer O Family O Registry O were O supported O by O grant O UM1 B-AWARD CA164920 I-AWARD from O the O USA O National B-ORG Cancer I-ORG Institute O This O work O was O also O supported O by O grants O to O kConFab O and O the O kConFab O Follow-Up O Study O from O Cancer B-ORG Australia I-ORG grant O numbers O 809195 B-AWARD 1100868 O the O Australian O National O Breast O Cancer O Foundation O grant O number O IF O 17 O kConFab O the O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG grant O numbers O 454508 B-AWARD 288704 I-AWARD 145684 O the O National B-ORG Institute I-ORG of I-ORG Health I-ORG U.S.A O grant O number O 1RO1CA159868 B-AWARD the O Queensland O Cancer O Fund O the O Cancer O Councils O of O New O South O Wales O Victoria O Tasmania O and O South O Australia O and O the O Cancer O Foundation O of O Western O Australia O grant O numbers O not O applicable O RDK O is O supported O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG National I-ORG Cancer I-ORG Institute I-ORG Cancer I-ORG Epidemiology I-ORG Training I-ORG Grant I-ORG grant O number O T32-CA009529 B-AWARD KAP O is O an O Australian O National O Breast O Cancer O Foundation O Practitioner O Fellow O This O study O was O supported O by O the O Ministry B-ORG of I-ORG Science I-ORG Innovation I-ORG and I-ORG Universities/the O European O Regional O Development O Fund O RTI2018-093525-B-I00 O Madrid O Spain O the O European B-ORG Union’s I-ORG Horizon I-ORG 2020 I-ORG Research I-ORG and I-ORG Innovation I-ORG Programme I-ORG under I-ORG the I-ORG Marie I-ORG Sklodowska-Curie I-ORG grant I-ORG agreement O No O 891663 O the O Seneca B-ORG Foundation I-ORG Murcia I-ORG Spain I-ORG Grant O Number O 19892/GERM/15 B-AWARD 20780/PD/18 B-AWARD and O the O Research B-ORG Council I-ORG FORMAS I-ORG Stockholm I-ORG Sweden I-ORG Projects O 2017-00946 I-AWARD and I-AWARD 2019-00288 O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 61805254 B-AWARD the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O no. O 2016YFC1400602 B-AWARD the B-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Instrument I-ORG and I-ORG Equipment I-ORG Function I-ORG Development I-ORG Technology I-ORG Innovation I-ORG Project I-ORG grant O no. O Y93H3g1251 B-AWARD the B-ORG Anhui I-ORG Provincial I-ORG Excellent I-ORG Youth I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 1908085J23 B-AWARD and O the B-ORG Marine I-ORG National I-ORG Laboratory I-ORG Open I-ORG Foundation I-ORG Program I-ORG of I-ORG China I-ORG grant O no. O QNLM2016ORP0312 B-AWARD This O work O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O 61672540 O 61379057 B-AWARD and O 61309001 B-AWARD the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG under O Grant O 2017JJ2057 O Project B-ORG of I-ORG Education I-ORG Department I-ORG of I-ORG Hunan I-ORG Province I-ORG 18A397 O and O the B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Yiyang I-ORG City I-ORG under O grant O YK1645 O This O project O was O supported O by O the O Grant O Agency O of O the O Ministry O of O Health O of O the O Czech O Republic O AZVNV18-03-00199 O the O Grant B-ORG Agency I-ORG of I-ORG the I-ORG Czech I-ORG Republic I-ORG GACR18-09709S O and O the O Charles B-ORG University I-ORG Grant I-ORG Agency I-ORG GAUK O 302119 O We O are O thankful O to O Charles O University O Research O Centre O program O UNCE/MED/006 O “University O Centre O of O Clinical O and O Experimental O Liver O Surgery” O and O National O Sustainability O Program O I O NPU O I) O Nr. O LO1503 O provided O by O the O Ministry O of O Education O Youth O and O Sports O of O the O Czech O Republic O This O article O is O based O upon O work O from O COST O Action O CA17118 B-AWARD supported O by O COST O European O Cooperation I-ORG in I-ORG Science I-ORG and I-ORG Technology).www.cost.eu O The O authors O are O supported O by O the O Aeronautical B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 2012ZD51043 B-AWARD Fanzhou B-ORG Youth I-ORG Scientific I-ORG Funds I-ORG No. O 20100504 B-AWARD Chinese O Government O Fundamental O Research O Funds O for O the O Central O Universities O No. O YWF-14-HKXY-017 O YWF-13-HKXY-033 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61403016 O This O study O was O supported O by O the O research O grants O from O the O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG 14DZ2260200 O Shanghai B-ORG Clinical I-ORG Medical I-ORG Center I-ORG for I-ORG Kidney I-ORG Disease I-ORG Project I-ORG support I-ORG by I-ORG Shanghai I-ORG Municipal I-ORG Health I-ORG Commission I-ORG 2017ZZ01015 O Shanghai B-ORG Municipal I-ORG Hospital I-ORG Frontier I-ORG Technology I-ORG Project I-ORG supported I-ORG by I-ORG Shanghai I-ORG ShenKang I-ORG Hospital I-ORG Development I-ORG Center I-ORG SHDC12018127 O and O the B-ORG Xiamen I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG in I-ORG 2018 I-ORG 3502Z20184009 O These O funding O have O no O role O in O the O design O of O study O data O collection O analysis O and O neither O interpretation O of O data O nor O writing O of O the O manuscript O This O research O was O funded O by O the O Natural B-ORG Science I-ORG Research I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG of I-ORG China I-ORG Grant O No. O 15KJB430011 B-AWARD and O six B-ORG talent I-ORG peaks I-ORG project I-ORG in I-ORG Jiangsu I-ORG Province I-ORG Grant O No. O 2015-XCL-028 B-AWARD and O policy B-ORG guiding I-ORG plan I-ORG university-industry I-ORG cooperation)-prospective I-ORG joint I-ORG research I-ORG project I-ORG BY2016073-02 O This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under I-ORG Grant I-ORG number O 71704070 B-AWARD Ministry B-ORG of I-ORG Education I-ORG for I-ORG the I-ORG Humanities I-ORG and I-ORG Social I-ORG Sciences I-ORG Research I-ORG Young I-ORG Fund I-ORG on I-ORG the I-ORG West I-ORG and I-ORG Borderland I-ORG Project I-ORG number O 17XJC790002 B-AWARD Guangdong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under I-ORG Grant I-ORG number O 2017A030313443];and B-AWARD Program B-ORG of I-ORG Lanzhou I-ORG University I-ORG of I-ORG Finance I-ORG and I-ORG Economics I-ORG under I-ORG Grant I-ORG number O Lzufe2018B-06 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 22008037 O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2020YFB0408100 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG of I-ORG China I-ORG 2023A1515011751 O and O NSFC B-ORG U20A20340 O This O is O independent O research O funded O by O the O UK O National O Institute O for O Health O Research O School O for O Public O Health O Research O NIHR O SPHR O The O views O expressed O are O those O of O the O author(s O and O not O necessarily O those O of O the O National O Health O Service O the O NIHR O or O the O Department O of O Health O The O NIHR O SPHR O is O a O partnership O between O the O Universities O of O Sheffield O Bristol O Cambridge O UCL O The O London O School O for O Hygiene O and O Tropical O Medicine O The O Peninsula O College O of O Medicine O and O Dentistry O the O LiLaC O collaboration O between O the O Universities O of O Liverpool O and O Lancaster O and O Fuse O the O Centre O for O Translational O Research O in O Public O Health O a O collaboration O between O Newcastle O Durham O Northumbria O Sunderland O and O Teesside O Universities O This O work O was O also O supported O by O the O Medical B-ORG Research I-ORG Council I-ORG Unit O Programme O numbers O MC_UU_12015/7 B-AWARD and O MC_UU_12015/2 B-AWARD and O undertaken O under O the O auspices O of O the O Centre O for O Diet O and O Activity O Research O a O United B-ORG Kingdom I-ORG Clinical I-ORG Research I-ORG Collaboration I-ORG UKCRC O Public O Health O Research O Centre O of O Excellence O which O is O funded O by O the O British O Heart O Foundation O Cancer O Research O UK, O Economic O and O Social O Research O Council O Medical O Research O Council O the O NIHR O and O the O Wellcome B-ORG Trust I-ORG RES-590-28-0002 O KH O is O a O Sir O Henry O Wellcome O Postdoctoral O Fellow O Wellcome O Trust O Grant O 107337/Z/15/Z B-AWARD The O present O study O was O funded O by O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq I-ORG Fundação I-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG do I-ORG Rio I-ORG Grande I-ORG do I-ORG Sul I-ORG FAPERGS O EDITAL B-AWARD PRONEX I-AWARD FAPERGS/CNPq I-AWARD 12/2014 I-AWARD processo I-AWARD 16/2551-0000492-7 O Fundo B-ORG de I-ORG Incentivo I-ORG à I-ORG Pesquisa I-ORG e I-ORG Eventos I-ORG do I-ORG Hospital I-ORG de I-ORG Clínicas I-ORG de I-ORG Porto I-ORG Alegre I-ORG FIPE-HCPA O n. O 150218 B-AWARD and O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG O Brasil O CAPES O O Finance B-AWARD Code I-AWARD 001 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG 2021A1515012480 O the O Guangzhou B-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG in I-ORG the I-ORG Key I-ORG Fields I-ORG China I-ORG 202103030003 O and O the O R&D B-ORG Plan I-ORG Project I-ORG in I-ORG the I-ORG Key I-ORG Fields I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG 2022B1111080007 O The O study O was O also O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2022YFC2403102 O This O research O was O supported O by O the O following O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31672363 O 31872262 B-AWARD the O National B-ORG Key I-ORG Program I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Foundation I-ORG Work I-ORG of I-ORG China I-ORG 2015FY210300 O and O the O Science B-ORG and I-ORG Technology I-ORG Research I-ORG Program I-ORG of I-ORG Chongqing I-ORG Municipal I-ORG Education I-ORG Commission I-ORG KJQN201800527 O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. I-AWARD 2016YFC0204402 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. I-AWARD 21304007 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No. I-AWARD JD1904 O This O work O was O partially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61702325 O National B-ORG Key I-ORG R&D I-ORG Program I-ORG Projects I-ORG 2018YFD0701003 O and O Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Action I-ORG Plan I-ORG 16391902900 O Publication O costs O were O funded O by O the O National O Natural O Science O Foundation O of O China O 61702325 O The O work O is O supported O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG Central I-ORG Universities I-ORG 2017B19714 O and O 2017B07414 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20180500 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jilin I-ORG Engineering I-ORG Normal I-ORG University I-ORG XYB201814 O Key B-ORG Projects I-ORG of I-ORG President I-ORG Foundation I-ORG of I-ORG Nanfang I-ORG Hospital I-ORG Southern I-ORG Medical I-ORG University I-ORG 2017A001 O Shanghai B-ORG Wang I-ORG Zhengguo I-ORG Trauma I-ORG Medical I-ORG Development I-ORG Foundation I-ORG 2017KJB-GK-001 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG Approval O no. O 2018A030313640 B-AWARD 2019A1515012176 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81101366 O This O work O was O supported O by O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Hainan I-ORG Province I-ORG ZDYF2019073 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31860702 O and O Hainan B-ORG University I-ORG Research O Fund O hdkytg201702 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82171546 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Province I-ORG 2008085MH277 O Anhui B-ORG Provincial I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG 2022e07020011 O We O thank O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O No. O 11704263 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG grant O No. O F2018501063 B-AWARD Hebei B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG Research I-ORG Funds I-ORG grant O No. O 18273902D B-AWARD for O financial O support O This O work O was O performed O in O part O at O the O Melbourne O Centre O for O Nanofabrication O MCN O in O the O Victorian O Node O of O the O Australian O National O Fabrication O Facility O ANFF O This O study O was O funded O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51879130 B-AWARD the B-ORG higher I-ORG discipline I-ORG innovation I-ORG and I-ORG talent I-ORG introduction I-ORG base I-ORG of I-ORG Henan I-ORG Province I-ORG No. O CXJD2019001 B-AWARD and O key B-ORG research I-ORG and I-ORG development I-ORG projects I-ORG of I-ORG Henan I-ORG Province I-ORG No. O 221111520600 B-AWARD This O study O was O funded O by O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG No.18080503100 O Shanghai B-ORG Education I-ORG Scientific I-ORG Research I-ORG Project I-ORG No.C160030 O Shanghai B-ORG Pujiang I-ORG Program I-ORG No.17PJC085 O The O authors O were O supported O by O the O National B-ORG High-Tech I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2013AA01A606 O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2014CB744600 O the O Key B-ORG Research I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG CAS I-ORG KJZD-EWL04 O the O CAS B-ORG Strategic I-ORG Priority I-ORG Research I-ORG Program I-ORG XDA06030800 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG NO. O BLX2015-42 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31370591 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No. O DL13CA07 B-AWARD Postdoctoral B-ORG Science I-ORG Start-up I-ORG Foundation I-ORG of I-ORG the I-ORG Heilongjiang I-ORG Province I-ORG Grant O No. O LBH-Q14012 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61574114 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFB0400801 B-AWARD the B-ORG fundamental I-ORG research I-ORG funds I-ORG for I-ORG the I-ORG central I-ORG universities I-ORG Z201805198 O SRL O is O an O Australian O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG NHMRC O Practitioner O Fellow O This O work O was O supported O by O grants O from O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH O U19-AI096109 B-AWARD and O 1R56AI095073-01A1 B-AWARD SRL O and O PUC O R21DA031036 B-AWARD and O R21AI106472 B-AWARD DV O the O American B-ORG Foundation I-ORG for I-ORG AIDS I-ORG Research I-ORG SS, O PUC O SRL O and O the O NHMRC O 491154 O and O 1002761 B-AWARD This O work O was O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31560222 O the O Science B-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG of I-ORG Guizhou I-ORG province I-ORG 20172558 O 20172557 B-AWARD 20175788 B-AWARD 20191404 B-AWARD the O USDA-NIFA B-ORG SCRI I-ORG grant I-ORG 2017-51181-26834 O the O Guizhou B-ORG Top I-ORG Level I-ORG Innovation I-ORG Talents I-ORG Cultivation I-ORG Project I-ORG 20164003 O the O Talent B-ORG Base I-ORG for I-ORG Germplasm I-ORG Resources I-ORG Utilization I-ORG and I-ORG Innovation I-ORG of I-ORG Characteristic I-ORG Plant I-ORG in I-ORG Guizhou I-ORG RCJD2018-14 O and O the O Genetically B-ORG Breeding I-ORG Major I-ORG Project I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Agriculture I-ORG of I-ORG China I-ORG 2016ZX08010-003 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O by O National B-ORG High-tech I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Grant O 2012AA021404 B-AWARD and O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant,2018M630382 O the O Nature B-ORG Science I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG Grant O QC2012C115 B-AWARD and O Academy B-ORG Level I-ORG Project I-ORG of I-ORG Heilongjiang I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences(Grant,2017BZ02 O The O authors O gratefully O acknowledge O funding O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 51875176 B-AWARD and O 51741503 B-AWARD the B-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Solidification I-ORG Processing I-ORG in I-ORG NWPU I-ORG grant O no. O SKLSP201631 B-AWARD the O Natural O Science O Foundation O of O Henan O Province O 162300410085 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG grant O no. O 2016M590677 B-AWARD and O National O Key O R&D O Program O of O China O 2017YFB0306400 O This O work O was O financially O supported O by O the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-47 O the O Guangzhou B-ORG Science I-ORG Technology I-ORG and I-ORG Innovation I-ORG Commission I-ORG Project I-ORG No. O 201510010071 B-AWARD and O the O Guangdong B-ORG Ocean I-ORG and I-ORG Fishery I-ORG Bureau I-ORG Project I-ORG 20164200042090023 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81503308 O 81673600 B-AWARD and O 81473147 B-AWARD the O Project B-ORG of I-ORG Administration I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG of I-ORG Jiangsu I-ORG Province I-ORG YB2015007 O the O Top-notch B-ORG Academic I-ORG Programs I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PPZY2015A070 O the O Postgraduate B-ORG Research I-ORG Innovation I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG KYLX16_1160 O the O Project B-ORG Funded I-ORG by I-ORG the I-ORG Priority I-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O the O Top-notch O Academic O Programs O Project O of O Jiangsu O Higher O Education O Institutions O TAPP O and O the O Open B-ORG Project I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Key I-ORG Laboratory I-ORG for I-ORG Pharmacology I-ORG and I-ORG Safety I-ORG Evaluation I-ORG of I-ORG Chinese I-ORG Materia I-ORG Medica I-ORG Nanjing I-ORG University I-ORG of I-ORG Chinese I-ORG Medicine I-ORG JKLPSE201608 O This O research O was O supported O by O the O Open B-ORG Project I-ORG Program I-ORG of I-ORG Hebei I-ORG Province I-ORG Collaborative I-ORG innovation I-ORG center I-ORG for I-ORG sustainable I-ORG utilization I-ORG of I-ORG water I-ORG resources I-ORG and I-ORG optimization I-ORG of I-ORG industrial I-ORG structure I-ORG XTZX202105 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG D2020504014 O Basic B-ORG Scientific I-ORG Research I-ORG Funds I-ORG of I-ORG China I-ORG Geological I-ORG Survey I-ORG SK202111 O This O work O was O supported O by O the O National B-ORG Science I-ORG Council I-ORG 99-2113-M-002-008-MY3 O to O N.C O 99-2320-B-002-058-MY3 B-AWARD and O 100-2325-B-002-019 B-AWARD to O T.L O National B-ORG Taiwan I-ORG University I-ORG College I-ORG of I-ORG Medicine I-ORG 99R311001 O to O N.C O and O T.L O and O National B-ORG Health I-ORG Research I-ORG Institute I-ORG EX100-9939NI O to O T.L O This O research O was O funded O by O the O projects O of O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0201300 O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-29 O Jiangsu O Agricultural O Industry O Technology O System O JATS O 417 O Jiangsu O Key O Agricultural O for O New O Cultivars O Innovation O PZCZ201723 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O NO.31901975 O and O 31972384 B-AWARD and O Jiangsu B-ORG Agriculture I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Fund I-ORG CX(19 O 2029 O This O research O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81901769 B-AWARD 82001852 B-AWARD 81727805 B-AWARD 82151316 B-AWARD the O Key B-ORG R&D I-ORG plan I-ORG of I-ORG Hubei I-ORG Province I-ORG grant O number O 2022BCA050 B-AWARD the O Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG under O Grant O SGDX20190917094601717 B-AWARD and O JCYJ20210324141216040 B-AWARD The O research O was O funded O by O the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China O grant O number O 2018 B-AWARD YFD0200303 O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 51875217 B-AWARD the B-ORG key I-ORG R&D I-ORG Program I-ORG of I-ORG Guangdong O grant O number O 2019B020221003 B-AWARD the B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars O grant O number O 2019B151502056 B-AWARD the O Earmarked B-ORG Fund I-ORG for I-ORG Modern I-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System O grant O number O CARS-01-43 B-AWARD L.Q O This O research O was O supported O by O National O Institutes O of O Health O NIH O grants O from O the O National B-ORG Center I-ORG for I-ORG Complementary I-ORG and I-ORG Integrative I-ORG Health I-ORG NCCIH O R61AT009333 B-AWARD Hecht O Epel O the O National B-ORG Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute I-ORG NHLBI O K23HL133442 B-AWARD Mason O the O National B-ORG Institute I-ORG of I-ORG Diabetes I-ORG and I-ORG Digestive I-ORG and I-ORG Kidney I-ORG Diseases I-ORG NIDDK O K01DK107456 B-AWARD Saslow O and O NCCIH O K24AT007827 O Hecht O This O study O is O funded O by O the O National B-ORG Institute I-ORG of I-ORG Diabetes I-ORG and I-ORG Digestive I-ORG and I-ORG Kidney I-ORG Diseases I-ORG of O the O National O Institutes O of O Health O 5R01DK109913 O 2P30DK092949 O and O P30DK092950 O the O National B-ORG Cancer I-ORG Institute I-ORG of O the O National O Institutes O of O Health O 1P50CA244431 O and O the O Centers B-ORG for I-ORG Disease I-ORG Control I-ORG and I-ORG Prevention I-ORG U48DP006395 O The O study O sponsor O was O not O involved O in O study O design O data O collection O analyses O or O reporting O of O findings O The O findings O and O conclusions O in O this O article O are O those O of O the O authors O and O do O not O necessarily O represent O the O official O positions O of O the O National O Institutes O of O Health O or O Centers O for O Disease O Control O and O Prevention O This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0900705 O Basic B-ORG Scientific I-ORG Fund I-ORG for I-ORG National I-ORG Public I-ORG Research I-ORG Institutes I-ORG of I-ORG China I-ORG 2022Q10 O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangxi I-ORG AA21196002 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32000074 O 42176130 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2021MD044 O Tai B-ORG Mountain I-ORG Industry I-ORG Leading I-ORG Talent I-ORG of I-ORG Shandong I-ORG 2019TSCYCX-06 O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG 2021TZXD008 O Biosafety B-ORG Research I-ORG Program I-ORG 20SWAQX04 O Shandong B-ORG Program I-ORG of I-ORG Qingdao I-ORG Pilot I-ORG National I-ORG Laboratory I-ORG for I-ORG Marine I-ORG Science I-ORG and I-ORG Technology I-ORG 2022QNLM030003-1 O and O Future B-ORG Industry I-ORG Cultivation I-ORG Project I-ORG of I-ORG Qingdao I-ORG 23-1-4-xxgg-20-nsh O This O work O was O supported O by O the O Guangdong B-ORG Medical I-ORG Research I-ORG Foundation O Grant O Number O A2017047 B-AWARD National B-ORG Institute I-ORG of I-ORG Neurological I-ORG Disorders I-ORG and I-ORG Stroke O Grant O Number I-AWARD R01NS098772 O and O National B-ORG Institute I-ORG on I-ORG Drug I-ORG Abuse O Grant O Number I-AWARD R01DA042852 O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 22102156 I-AWARD and O 21875221 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2021TQ0295 O and O 2022M712865 B-AWARD the O Distinguished B-ORG Young I-ORG Scholars I-ORG Innovation I-ORG Team I-ORG of I-ORG Zhengzhou I-ORG University I-ORG No. O 32320275 O and O the O Academic B-ORG Degrees I-ORG and I-ORG Graduate I-ORG Education I-ORG Reform I-ORG Project I-ORG of I-ORG Henan I-ORG Province I-ORG 2021 O SJGLX I-AWARD 093Y O This O work O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0100903 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31370222 O 31425018 O National B-ORG Program I-ORG on I-ORG the I-ORG Development I-ORG of I-ORG Basic I-ORG Research I-ORG 2013CB126900 O Specialized B-ORG Research I-ORG Fund I-ORG for I-ORG the I-ORG Doctoral I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG 20130146110012 O and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2015PY003 O 2013PY062 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O National B-ORG Marine I-ORG Economic I-ORG Innovation I-ORG and I-ORG Development I-ORG Project I-ORG 16PYY007SF17 O United B-ORG Fujian I-ORG Provincial I-ORG Health I-ORG and I-ORG Education I-ORG Project I-ORG for I-ORG Tacking I-ORG the I-ORG Key I-ORG Research I-ORG WKJ2016-2-22 O and O Subsidized B-ORG Project I-ORG for I-ORG Cultivating I-ORG Postgraduates’ I-ORG Innovative I-ORG Ability I-ORG in I-ORG Scientific I-ORG Research I-ORG of I-ORG Huaqiao I-ORG University I-ORG 1611315029 O This O work O was O supported O by O Immunexpress O the O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG University O College O London O Hospitals O Biomedical O Research O Centre O NIHR O fellowship O award O to O LS O CS_2016_16_007 O Wellcome B-ORG Trust I-ORG awards O to O MN O 207511/Z/17/Z O and O EG O 107311/Z/15/Z O and O Medical B-ORG Research I-ORG Council I-ORG award O to O JR O MR/L001756/1 O This O study O was O supported O by O a O grant O from O the O Youth B-ORG Development I-ORG Fund I-ORG of I-ORG The I-ORG First I-ORG Hospital I-ORG of I-ORG Jilin I-ORG University I-ORG JDYY52015019 O to O Baochang O Qi O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81172183 B-AWARD to O Tiecheng O Yu. O This O project O was O also O supported O by O AO B-ORG Trauma I-ORG Asia I-ORG Pacific I-ORG Ref O AOTAP15-01 B-AWARD to O Baochang O Qi O and O in O part O by O National B-ORG Institutes I-ORG of I-ORG Health I-ORG grants I-ORG GM-51477 B-AWARD GM-60475 I-AWARD AI-080582 I-AWARD and I-AWARD T32GM103702 I-AWARD to O W.G.J O The O funding O bodies O did O not O have O any O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O The O work O was O financially O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 31300426 B-AWARD and O 31870635 B-AWARD the B-ORG Open I-ORG fund I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Tea I-ORG Plant I-ORG Biology I-ORG and I-ORG Utilization I-ORG SKLTOF201801109 O and O the B-ORG Anhui I-ORG Provinical I-ORG Important I-ORG Science I-ORG I-ORG Technology I-ORG Specific I-ORG Projects I-ORG 201903a06020019 O Funding O was O provided O by O National B-ORG Institute I-ORG on I-ORG Drug I-ORG Abuse I-ORG NIDA O Grant O R25DA037190 O The O Lifespan/Brown O Criminal O Justice O Research O Program O on O Substance O Use O HIV O and O Comorbidities O The B-ORG Providence/Boston I-ORG Center I-ORG for I-ORG AIDS I-ORG Research I-ORG Grant O P30AI042853 O and O The B-ORG Boston I-ORG Obesity I-ORG Research I-ORG Center I-ORG Grant O P30DK046200 O The O authors O thank O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grants O 81570884 I-AWARD 81770961 O the B-ORG SMC-ChenXing I-ORG Yong I-ORG Scholar I-ORG Program I-ORG 2016 O Class I-AWARD A) O and O the B-ORG Shanghai I-ORG Municipal I-ORG Education I-ORG Commission-Gaofeng I-ORG Clinical I-ORG Medicine I-ORG Grant I-ORG 20152223 O and O Innovation B-ORG Fund I-ORG for I-ORG Translational I-ORG Medicine I-ORG 15ZH1005 O Ph.D B-ORG Programs I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG JiaoTong I-ORG University I-ORG School I-ORG of I-ORG Medicine I-ORG BXJ201834 O The O funders O had O no O role O in O the O design O of O the O study O or O in O the O collection O analysis O and O interpretation O of O data O or O in O writing O the O manuscript O This O research O was O funded O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 82101789 B-AWARD Changsha B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O No. O Kq2202369 B-AWARD General B-ORG project I-ORG of I-ORG Hunan I-ORG Provincial I-ORG Health I-ORG Commission I-ORG Grant O No. O B202305026242 B-AWARD This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 21606211 B-AWARD Science B-ORG and I-ORG Technique I-ORG Foundation I-ORG Foundation I-ORG and I-ORG Frontier I-ORG Projects I-ORG of I-ORG He’nan I-ORG Province O grant O number O 152300410127 B-AWARD and O Doctoral B-ORG Research I-ORG Fund I-ORG of I-ORG Zhengzhou I-ORG University I-ORG of I-ORG Light I-ORG Industry O grant O number O 2014BSJJ056 B-AWARD This O research O has O received O funding O from O the O European B-ORG Union I-ORG Seventh I-ORG Framework I-ORG Programme O under O grant O agreement O no. O 604391 B-AWARD Graphene B-ORG Flagship I-ORG EPSRC I-ORG award O no. O EP/I023879/1 B-AWARD and O AFOSR/EOARD B-ORG award O no. O FA8655-12-1-2058 B-AWARD One O of O the O authors O Z-L.L O is O grateful O to O the O China O Scholarship O Council O for O financial O support O This O work O was O supported O by O Project B-ORG of I-ORG Science I-ORG and I-ORG Technique I-ORG of I-ORG Henan I-ORG China I-ORG No. O 092102310007 B-AWARD Project O of O Medical B-ORG Science I-ORG and I-ORG Technique I-ORG of I-ORG Henan I-ORG China I-ORG No. O 201304053 B-AWARD and O the B-ORG Special I-ORG Funding I-ORG of I-ORG the I-ORG Henan I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Talent I-ORG Project I-ORG No.4045 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O paper O This O work O was O supported O by O the O EU B-ORG Grant O No. O 2D-SMARTiES B-AWARD ERC-StG-101042680 O the O Plan B-ORG Gent I-ORG of I-ORG Excellence I-ORG of I-ORG the I-ORG Generalitat I-ORG Valenciana I-ORG Grant O No. O CDEIGENT/2019/022 B-AWARD the O Spanish B-ORG MIU I-ORG Grant O No. O FPU21/04195 B-AWARD and O the O Excellence B-ORG Unit I-ORG María I-ORG de I-ORG Maeztu I-ORG Grant O No. O CEX2019-000919-M B-AWARD from O the O Spanish O MICINN O This O work O was O supported O by O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo O research O grant O 2015/21072-5 B-AWARD to O M.P O 2016/15603-0 B-AWARD to O M.P O and O M.L.C.G O 2016/00696-3 B-AWARD to O G.E.R O 2018/18545-4 B-AWARD to O M.F.M.S O and O 2017/07725-1 O to O A.R.M.S O and O G.E.R O and O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior—Brasil O CAPES)—Finance O Code I-AWARD 001 I-AWARD to O M.F.M.S O M.P O and O M.L.C.G O are O recipients O of O a O research O award O 30395/2021-0 B-AWARD from O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico O CNPq O Brazil O This O research O was O supported O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 22022YFD1301003 O 2022YFD1301004 B-AWARD The B-ORG earmarked I-ORG fund I-ORG for I-ORG CARS I-ORG CARS-36 O The B-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG ASTIP-IAS12 O the O Xinjiang B-ORG Tianshan I-ORG Innovation I-ORG Team I-ORG 2022D14016 O and O Xinjiang B-ORG science I-ORG and I-ORG technology I-ORG projects I-ORG 2022A02006-3-1 O This O work O was O supported O in O part O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG no. O 2016YFC1102003 B-AWARD Chengdu B-ORG science I-ORG and I-ORG technology I-ORG project I-ORG no. O 2017-CY02-00032-GX B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 81801852 B-AWARD and O National O Key O Research O and O Development O Program O of O China O no. O 2017YFB0702604 B-AWARD This O research O was O funded O by O the O National B-ORG Nature I-ORG Science I-ORG Foundations I-ORG of I-ORG China I-ORG NSFC I-ORG 31272051 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0200400 O the O Special B-ORG Program I-ORG for I-ORG New I-ORG Transgenic I-ORG Variety I-ORG Breeding I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG China I-ORG 2016ZX08012005 O and O the O Research B-ORG Grant I-ORG from I-ORG the I-ORG Innovation I-ORG Project I-ORG for I-ORG Graduate I-ORG Student I-ORG of I-ORG Jiangsu I-ORG Province I-ORG KYLX16_1063 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O number O 82060492 O the B-ORG National I-ORG College I-ORG Students’ I-ORG Innovative I-ORG Entrepreneurial I-ORG Training I-ORG Plan I-ORG Program I-ORG Grant O numbers O 202110403003 O and O 202210403001 O and O the B-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Training I-ORG Program I-ORG for I-ORG College I-ORG Students I-ORG in I-ORG Jiangxi I-ORG Province I-ORG Grant O number O S202210403002 O This O work O was O supported O by O Doctoral B-ORG Foundation I-ORG of I-ORG Southwest I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Nos O 19zx7156 B-AWARD and O 20zx7121 B-AWARD Industry-University B-ORG Cooperation I-ORG Collaborative I-ORG Education I-ORG Project I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG grant O number O 202101097010 B-AWARD and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Sichuan I-ORG Province I-ORG Nos O 2022NSFSC0953 B-AWARD 2021YFG0374 B-AWARD and O 2022YFG0259 B-AWARD This O study O was O funded O by O grants O from O the O National B-ORG Clinical I-ORG Research I-ORG Center I-ORG for I-ORG Geriatric I-ORG Diseases I-ORG of I-ORG China I-ORG No. O NCRCG-PLAGH-2017008 B-AWARD WU B-ORG JIEPING I-ORG MEDICAL I-ORG FOUNDATION I-ORG No. O 320.6750.18383 B-AWARD and O Beijing B-ORG Municipal I-ORG Capital I-ORG Specialized I-ORG Clinical I-ORG Application I-ORG Research I-ORG Program I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG Foundation O No. O Z161100000116054 B-AWARD The O work O was O supported O by O Major B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG for I-ORG Water I-ORG Pollution I-ORG Control I-ORG and I-ORG Treatment I-ORG 2012ZX07201002-6 O National B-ORG Scientific I-ORG Funding I-ORG of I-ORG China I-ORG no. O 51378003 B-AWARD and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG FRF-BD-17-014A O This O work O was O supported O by O the10.13039/501100001809National O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China[grant O numbers O 81970003 B-AWARD 31500143 B-AWARD theNational O Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG China[grant O numbers O 2018ZX10102001 B-AWARD 2017ZX10103011 B-AWARD and10.13039/501100004000Guangzhou O Science I-ORG and I-ORG Technology I-ORG Program I-ORG key I-ORG projects[grant O number O 201803040004 B-AWARD This O study O was O supported O by O the O General B-ORG Program I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 31372406 B-AWARD and I-AWARD 31571432 O the O Hunan B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 2018JJ2177 B-AWARD and O the O Research B-ORG Foundation I-ORG of I-ORG Hunan I-ORG Provincial I-ORG Education I-ORG Department I-ORG China I-ORG Grant O No. O 15A086 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the B-ORG Fund I-ORG of I-ORG Transgenic I-ORG Breeding I-ORG for I-ORG Soybean I-ORG Resistance I-ORG to I-ORG Soybean I-ORG mosaic I-ORG virus I-ORG 2016ZX08004-004 O , O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG KYT201801 O Program O for O Changjiang O Scholars O and O Innovative O Research O Team O in O University O PCSIRT_17R55 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31571690 O the O National O Soybean O Industrial O Technology O System O of O China O CARS-004 O Jiangsu O Collaborative O Innovation O Center O for O Modern O Crop O Production O JCIC-MCP O and O the O National O Key O R&D O Program O of O China O 2017YFD0101501 O The O authors O received O funding O from O RH B-ORG Forskningspulje O R143-A6132-B3632 B-AWARD Savværksejer B-ORG Jeppe I-ORG Juhl I-ORG og I-ORG Hustru I-ORG Ovita I-ORG Juhls I-ORG Mindelegat O 27062019 B-AWARD Deutsche B-ORG Forschungsgemeinschaft I-ORG DFG O DFG B-AWARD DR I-AWARD 323/5-1 I-AWARD DFG I-AWARD DR I-AWARD 323/10-1 I-AWARD and I-AWARD FP7 O 602150 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O financially O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC1600904 O 2017YFD0401200 O Jiangsu B-ORG Agriculture I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Fund I-ORG CX(17)1003 B-AWARD Open B-ORG Foundation I-ORG of I-ORG Beijing I-ORG Advanced I-ORG Innovation I-ORG Center I-ORG for I-ORG Food I-ORG Nutrition I-ORG and I-ORG Human I-ORG Health I-ORG 20182014 O China B-ORG Agriculture I-ORG Research I-ORG System(CARS-02-32 O Zhejiang B-ORG Food I-ORG and I-ORG Drug I-ORG Administration I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 2018 O 201802 O 201811 O Science B-ORG and I-ORG technology I-ORG research I-ORG and I-ORG development I-ORG promotion I-ORG project I-ORG of I-ORG Beijing I-ORG Vocational I-ORG College I-ORG of I-ORG Agriculture I-ORG XY-YT-16-44 O National B-ORG first-class I-ORG discipline I-ORG program I-ORG of I-ORG Food I-ORG Science I-ORG and I-ORG Technology I-ORG JUFSTR20180203 O This O work O was O funded O in O part O by O the O Division B-ORG of I-ORG Chemical I-ORG Bioengineering I-ORG Environmental I-ORG and I-ORG Transport I-ORG Systems O National B-ORG Science I-ORG Foundation I-ORG Energy O for O Sustainability O program O CBET-1133319 O NSF O REU O program O EEC-1156933 O the O Iowa B-ORG Energy I-ORG Center I-ORG 12-06 O and O the O Iowa O State O University O Bioeconomy O Institute O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFA0901702 O Tianjin B-ORG Key I-ORG Medical I-ORG Discipline I-ORG Specialty I-ORG Construction I-ORG Project I-ORG TJYXZDXK-056B O the O Shandong B-ORG Key I-ORG R&D I-ORG Program I-ORG 2019GSF107088 O and O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG ZR2020MC077 O ZR202111220001 B-AWARD The O project O was O supported O by O grants O from O the B-ORG Natural I-ORG and I-ORG Science I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Provence I-ORG No. O ZD2019C003 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Nos O 2572017ET01 B-AWARD and O 2572017EA05 B-AWARD Foundation B-ORG of I-ORG Shanghai I-ORG Science I-ORG and I-ORG Technology I-ORG Committee I-ORG China I-ORG No. O 17391900600 B-AWARD the O Fund B-ORG of I-ORG Shanghai I-ORG Engineering I-ORG Research I-ORG Center I-ORG of I-ORG Plant I-ORG Germplasm I-ORG Resources I-ORG No. O 17DZ2252700 B-AWARD The O funding O agencies O of O this O study O had O no O role O in O the O design O of O the O study O data O collection O and O analysis O interpretation O of O data O the O decision O to O submit O the O report O for O publication O or O preparation O of O the O manuscript O This O work O was O partially O supported O by O the O Cohort O Study O of O Cerebral O White O Matter O Change O SWATCH O Multicenter O Network O ChiCTR1800015295 O This O study O was O supported O by O the O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81571086 B-AWARD 81870889 B-AWARD 81600978 B-AWARD 81200965 B-AWARD and O 81430022 B-AWARD National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFC1305804 B-AWARD and O 2017YFC1310200 B-AWARD Doctoral B-ORG Innovation I-ORG Fund I-ORG of I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG School I-ORG of I-ORG Medicine I-ORG No. O BXJ201913 B-AWARD Shanghai B-ORG Municipal I-ORG Education I-ORG Commission-Gaofeng I-ORG Clinical I-ORG Medicine I-ORG Grant I-ORG Support I-ORG No. O 20161401 B-AWARD Interdisciplinary B-ORG Project I-ORG of I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG No. O YG2016MS64 B-AWARD the O Research B-ORG Fund I-ORG for I-ORG the I-ORG Doctoral I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG No. O 20110073120088 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Shanghai I-ORG No. O 15ZR1426700 B-AWARD and O Guang B-ORG Ci I-ORG Qing I-ORG Nian I-ORG Grant I-ORG No. O GCQN-2017-A03 B-AWARD This O study O was O supported O by O funding O from O the O High B-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 863 O Program O No.2013AA102902 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31601256 B-AWARD the O special O fund O for O Agro-scientific B-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG 201303104 O and O the O 111 B-ORG Project I-ORG of I-ORG Chinese I-ORG Education I-ORG Ministry I-ORG B12007 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O authors O gratefully O acknowledge O the O financial O support O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 21808039 B-AWARD No. O 21676058 B-AWARD No. O 51873042 B-AWARD and O No. O 21706038 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2018A030310525 B-AWARD No. O 2016A030313694 B-AWARD W.J O Lin O also O acknowledges O the O financial O support O provided O by O the O Research O Fund O Program O GC201807 O of O Guangdong B-ORG Provincial I-ORG Key I-ORG Lab I-ORG of I-ORG Green I-ORG Chemical I-ORG Product I-ORG Technology O and O the O “One-Hundred B-ORG Young I-ORG Talents” I-ORG of I-ORG Guangdong I-ORG University I-ORG of I-ORG Technology I-ORG No. O 220413593 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31670978/31370991/21676041 O the O Fok B-ORG Ying I-ORG Tung I-ORG Education I-ORG Foundation I-ORG 132027 O the O State O Key O Laboratory O of O Fine O Chemicals O KF1111 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG 20180510028 O This O research O was O funded O by O the O National B-ORG Science I-ORG Foundation I-ORG IOS-0951010 O to O R.W.C O Postdoctoral O Research O Fellowship O in O Biology O 1711141 B-AWARD to O M.L.H O an O American B-ORG Society I-ORG of I-ORG Naturalists I-ORG Graduate B-AWARD Research I-AWARD Award I-AWARD to O M.L.H O the O Mildred O E. O Mathias O Graduate O Student B-AWARD Research I-AWARD Grant I-AWARD to O B.J.P O and O the O Animal B-ORG Behavior I-ORG Society I-ORG Student O Research O Grant O to O B.J.P O L.K O was O supported O by O Jill O Barrett O Biology O Undergraduate O Research O Program O at O Mills O College O J.E.S O was O funded O by O the O Letts-Villard O Endowed O Professorship O in O Natural O Sciences O at O Mills O College O the O Undergraduate B-AWARD Education I-AWARD Program I-AWARD of O the O W. B-ORG M. I-ORG Keck I-ORG Foundation O the O Barrett O Foundation O and O the O Joseph O and O Vera O Long O Foundation O This O work O was O supported O by O the O Guangdong B-ORG Natural I-ORG Science I-ORG Funds I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG 2016A030306047 O Pearl O River O S&T O Nova O Program O of O Guangzhou O 201610010138 O the O Youth B-ORG Innovation I-ORG Promotion I-ORG Association I-ORG CAS I-ORG 2017398 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31771423 B-AWARD This O work O was O also O supported O by O the O Ministry O of O Science O and O Technology O of O Taiwan O 105-2311-B-002-012-MY3 O and O 106-2313-B-002-003 O and O National O Taiwan O University O NTU-AS O 108L104310 O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 62001281 B-AWARD the O Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Committee I-ORG No. O 22dz1204300 B-AWARD and O the O Shanghai B-ORG Outstanding I-ORG Academic I-ORG Leaders I-ORG Plan I-ORG No. O 20XD1421700 B-AWARD This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0101805 O the O Shanghai B-ORG Agriculture I-ORG Applied I-ORG Technology I-ORG Development I-ORG Program I-ORG China I-ORG Grant O No. O G2016060105 B-AWARD and O the O Youth B-ORG Talent I-ORG Development I-ORG Plan I-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Agricultural I-ORG System I-ORG China I-ORG Grant O No. O 20180116 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 31971714 B-AWARD Educational B-ORG Commission I-ORG of I-ORG Liaoning I-ORG Province I-ORG of I-ORG China O grant O number O LJK0687 B-AWARD and O Shenyang B-ORG Agricultural I-ORG University I-ORG Student I-ORG Innovation I-ORG and I-ORG Venture I-ORG Fund O grant O number O SNDC301 B-AWARD This O study O was O financially O supported O by O the O Key B-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG the I-ORG Higher I-ORG Education I-ORG Institutions I-ORG of I-ORG Henan I-ORG Province I-ORG 21A210022 O the O Research B-ORG and I-ORG Practice I-ORG Project I-ORG of I-ORG Higher I-ORG Education I-ORG Teaching I-ORG Reform I-ORG in I-ORG Henan I-ORG Province I-ORG 2021SJGLX086 O and O the O Open B-ORG Research I-ORG Project I-ORG of I-ORG the I-ORG Innovation I-ORG Center I-ORG for I-ORG the I-ORG Efficient I-ORG Use I-ORG of I-ORG Nitrogen I-ORG Fertilizer I-ORG from I-ORG Henan I-ORG Xinlianxin I-ORG Chemical I-ORG Industry I-ORG Group I-ORG Co I-ORG Ltd I-ORG 30801723 O This O research O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81602196,81874087 O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFA0101200 O 2016YFC1201801 O and O the O Chongqing B-ORG Basic I-ORG Research I-ORG Project I-ORG cstc2016jcyjA2194 O The O funds O mentioned O were O used O for O the O design O of O the O study O the O collection O analysis O and O interpretation O of O the O data O as O well O as O the O writing O of O the O manuscript O Jiangsu B-ORG Provincial I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Special I-ORG Fund I-ORG BE2015666 O Jiangsu B-ORG Innovative I-ORG team I-ORG leading I-ORG talent I-ORG fund I-ORG CXTDC2016006 O Jiangsu B-ORG Natural I-ORG Science I-ORG Foundation I-ORG BK20171304 O Jiangsu B-ORG six I-ORG high I-ORG peak I-ORG talent I-ORG fund I-ORG WSW-205 O Jiangsu B-ORG 333 I-ORG talent I-ORG fund I-ORG BRA2016140 O and O Suqian B-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Project I-ORG S201522 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31671688 B-AWARD the B-ORG Meritocracy I-ORG Research I-ORG Funds I-ORG of I-ORG China I-ORG West I-ORG Normal I-ORG University I-ORG Grant O No. O 17YC145 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG of I-ORG China I-ORG West I-ORG Normal I-ORG University I-ORG Grant O No. O 17E055 B-AWARD This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0201900 O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-15-19 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG Central I-ORG Non-profit I-ORG Scientific I-ORG Institution I-ORG Y2018PT73 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Special B-ORG Funds I-ORG for I-ORG Industrial I-ORG Technology I-ORG Innovation I-ORG of I-ORG Suzhou I-ORG SYS201567 B-AWARD to O Jianrong O Dai O Clinical B-ORG Medical I-ORG Centers I-ORG of I-ORG Suzhou I-ORG SZZX201505 B-AWARD to O Jianrong O Dai O Introduce B-ORG Project I-ORG of I-ORG Clinical I-ORG Medicine I-ORG Experts I-ORG of I-ORG Suzhou I-ORG SZYJTD201707 B-AWARD to O Jianrong O Dai O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61601332 O 31301148 B-AWARD the O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG LQ16F010009 O the O Public B-ORG Welfare I-ORG Technology I-ORG Application I-ORG Research I-ORG Plan I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Science I-ORG and I-ORG Technology I-ORG Department(2017C32103 O and O the O Special B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG for I-ORG Seeds I-ORG and I-ORG Seedlings I-ORG of I-ORG Wenzhou I-ORG City(N20160017 O The O funders O played O no O role O in O study O design O data O collection O analysis O or O interpretation O of O the O data O Our O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Fund I-ORG of I-ORG China I-ORG No. O 31360521 O Science B-ORG and I-ORG technology I-ORG project I-ORG of I-ORG Jiangxi I-ORG Province I-ORG 20132BAB214013 O 2013BBG7004 O and O Doctoral B-ORG Scientific I-ORG Fund I-ORG Project I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG 20123603120003 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Support O was O provided O by O Grantová B-ORG Agentura I-ORG Univerzita I-ORG Karlova O 355511 B-AWARD to O MSc O Markéta O Knitlová O SVV B-ORG Programme I-ORG Charles I-ORG University O 260313/2016 B-AWARD to O MSc O Markéta O Knitlová O Grantová B-ORG Agentura I-ORG České I-ORG Republiky O 13-08169S B-AWARD to O Dr. O Ivan O Horáček O This O work O is O supported O by O the O NSFC B-ORG Excellent I-ORG Young I-ORG Scholars I-ORG Program O under O Grants O 61722212 B-AWARD in O part O by O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grants O 61873212 B-AWARD 61861146002 B-AWARD 61732012 B-AWARD in O part O by O the O West B-ORG Light I-ORG Foundation I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences O Grants O 2017-XBZG-BR-001 B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 863 O Program O 2014AA020610 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81771489 O 81672495 B-AWARD Beijing B-ORG Municipal I-ORG Science I-ORG I-ORG Technology I-ORG Commission I-ORG Z171100000117002 O Beijing B-ORG Talents I-ORG Fund I-ORG 2015000021223ZK24 O and O China B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2017YFC0908300 O Xinjiang B-ORG Uygur I-ORG Autonomous I-ORG Region I-ORG Natural I-ORG Science I-ORG Fund I-ORG Project I-ORG 2018D01C092 O This O work O was O supported O by: O The B-ORG Public I-ORG Welfare I-ORG Scientific I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Wenzhou I-ORG City I-ORG No.Y20140743 O The B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No.2016C37132 O and O The B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province(No.LY17H040009 O This O work O was O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81200826 B-AWARD Special B-ORG Funding I-ORG for I-ORG Development I-ORG of I-ORG Clinical I-ORG Medicine I-ORG by I-ORG Beijing I-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospitals I-ORG No. O XMLX201301 B-AWARD and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFB1101200 B-AWARD This O work O was O supported O by O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG of I-ORG China I-ORG 2015BAD01B01-1 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31671664 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0100101 O 2016YFD0100301 O CAAS B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG National I-ORG Infrastructure I-ORG for I-ORG Crop I-ORG Germplasm I-ORG Resources I-ORG NICGR2017-01 O and O Protective B-ORG Program I-ORG of I-ORG Crop I-ORG Germplasm I-ORG of I-ORG China I-ORG 2017NWB036-01 O 2017NWB036-12-2 O The O work O was O sponsored O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81772338 O and O 81572122 B-AWARD the O Interdisciplinary B-ORG Program I-ORG of I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG YG2017ZD05 O and O the O Shanghai B-ORG Leading I-ORG Talent I-ORG Plan I-ORG 043 O This O research O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81371207 O 81171047 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG of I-ORG China I-ORG BK20170129 O and O Key B-ORG Talent’s I-ORG of I-ORG 13th I-ORG Five-Year I-ORG Plan I-ORG for I-ORG Strengthening I-ORG Health I-ORG of I-ORG Jiangsu I-ORG Province I-ORG ZDRCA2016069 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Numbers O 81772152 B-AWARD 81701977 B-AWARD the B-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Infectious I-ORG Disease I-ORG Prevention I-ORG and I-ORG Control I-ORG Grant O Number O 2015SKLID504 B-AWARD and O the O National B-ORG Basic I-ORG Research I-ORG Priorities I-ORG Program I-ORG of I-ORG China I-ORG Grant O Number O 2015CB554201 B-AWARD This O research O was O funded O by O Characteristic B-ORG Innovation I-ORG Project I-ORG Natural I-ORG Science I-ORG of I-ORG Ordinary I-ORG Colleges I-ORG and I-ORG Universities I-ORG in I-ORG Guangdong I-ORG Province I-ORG Grant O No. O 2021KTSCX111 B-AWARD Shenzhen B-ORG Pingshan I-ORG District I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Special I-ORG Supporting I-ORG Project I-ORG Grant O No. O PSKG202006 B-AWARD Self-made B-ORG instrument I-ORG project I-ORG of I-ORG Shenzhen I-ORG Technology I-ORG University I-ORG Grant O No. O JSZZ202102023 B-AWARD Stable B-ORG support I-ORG fund I-ORG for I-ORG higher I-ORG education I-ORG institutions I-ORG of I-ORG Shenzhen I-ORG General O project O Grant O No. O 20220718183230002 B-AWARD This O research O was O partly O supported O by O German B-ORG Research I-ORG Foundation I-ORG DFG O AL902/4-1 B-AWARD to O B.A.www.dfg.de O the O PLANTFOODSEC B-ORG project I-ORG of I-ORG the I-ORG European I-ORG Union I-ORG FP7/2007-2013 O No. O 261752,https://cordis.europa.eu/project/rcn/100052_en.html B-AWARD and O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2017M622304 I-AWARD support O to O ZG,www.chinapostdoctor.org.cn O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Funding O for O this O study O was O provided O by O the O Health B-ORG Research I-ORG Board I-ORG of I-ORG Ireland I-ORG health O research O award O HRA-PHS/2015/1142 O and O a O Science B-ORG Foundation I-ORG Ireland-Brazil O International O Strategic O Cooperation O Award O 13/ISCA/2843 O to O DJH O MAP O and O AES O Support O for O this O study O was O also O provided O by O the O COST O Action O CA17118 O supported O by O COST O European O Cooperation O in O Science O and O Technology,www.cost.eu O to O DJH O VV, O and O PV. O The O co-authors O from O the O Czech O Republic O received O support O from O the O Ministry B-ORG of I-ORG Health I-ORG of I-ORG the I-ORG Czech I-ORG Republic I-ORG AZV O 15-27580A I-AWARD and O AZV B-AWARD NV I-AWARD 18-03-00199 O Natural B-ORG Sciences I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province O Grant/Award O Number O BK20221268 B-AWARD Genetic B-ORG improvement I-ORG of I-ORG sea I-ORG bream I-ORG and I-ORG creation I-ORG of I-ORG new I-ORG strains O Grant/Award O Number O PZCZ201744 B-AWARD Jiangsu B-ORG Province I-ORG “333 I-ORG Project” I-ORG Talent I-ORG Funding I-ORG “Exploring O the O low O temperature O tolerance O mechanism O and O genetic O mechanism O of O black O porgy O based O on O whole O genome O and O transcriptome O data” O Grant/Award O Number O BRA2020372 B-AWARD Jiangsu B-ORG Provincial I-ORG Agricultural I-ORG Project I-ORG “Conservation I-ORG and I-ORG renewal I-ORG of I-ORG improved I-ORG aquatic I-ORG species” O Grant/Award O Number O 2021-SJ-032 B-AWARD Major B-ORG agricultural I-ORG technology I-ORG collaborative I-ORG promotion I-ORG project O “Green O and O healthy O culture O technology O of O marine O economic O fish” O Grant/Award O Number O 2021-ZYXT-09 B-AWARD This O study O was O supported O by O the O Hainan B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Special I-ORG Fund I-ORG ZDYF2023XDNY084 O the O China B-ORG Earmarked I-ORG Fund I-ORG for I-ORG Modern I-ORG Agroindustry I-ORG Technology I-ORG Research I-ORG System I-ORG CARS-25 O and O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG CAAS-ASTIP O the O Xinjiang B-ORG Production I-ORG and I-ORG Construction I-ORG Corps’ I-ORG Scientific I-ORG and I-ORG Technological I-ORG Research I-ORG Plan I-ORG Project I-ORG in I-ORG Agriculture I-ORG 2022AB015 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0201300 O Financial O support O was O provided O by O University B-ORG Medicine I-ORG Greifswald O Germany O grant O number O 97237000;https://www.medizin.uni-greifswald.de B-AWARD recipient O HNL O Deutsche B-ORG Forschungsgemeinschaft I-ORG DFG O Germany O grant O number O SI-2147/1–1;http://www.dfg.de B-AWARD recipient O NS) O and O Peter B-ORG und I-ORG Traudl I-ORG Engelhorn I-ORG Stiftung O Germany O https://engelhorn-stiftung.de O recipient O MM O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O grants O from O the O Collaborative B-ORG Innovation I-ORG Center I-ORG for I-ORG Brain I-ORG Science I-ORG of I-ORG Chongqing I-ORG NO.4174D7 O and O the O Technology B-ORG Innovation I-ORG and I-ORG Application I-ORG Demonstration I-ORG Project I-ORG of I-ORG Chongqing I-ORG NO. O cstc2018jscx-msybX0092 B-AWARD the O Clinical B-ORG New I-ORG Technology I-ORG Key I-ORG Project I-ORG of I-ORG Southwest I-ORG Hospital I-ORG NO. O SWH2016JSTSZD-04 B-AWARD SWH2017ZDCX2010 B-AWARD The O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Fund I-ORG of I-ORG China I-ORG Grant O No. O 31971785 B-AWARD 31501219 O 41801245 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG China I-ORG Grant O No. O 2020TC036 B-AWARD and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2016YFD0200600-2016YFD0200602 B-AWARD And O the O article O processing O charge O APC O was O funded O by O the O National O Natural O Science O Fund O of O China O Grant O No. O 31971785 O This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFA0604403 O and O 2016YFA0602301 B-AWARD the O Joint B-ORG Fund I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U19A2023 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jilin I-ORG Province I-ORG China I-ORG 20170101013JC O This O work O was O supported O by O theDepartment O for I-ORG International I-ORG Cooperation O Barcelona O City O Hall O Spain O Grant O No. O 12S05844 B-AWARD theAga O Khan I-ORG Foundation(AKF O and O theGlobal O Alliance I-ORG for I-ORG Vaccination I-ORG and I-ORG Immunization(GAVI O Grant O Numbers O 1415-MOZ-19a-X B-AWARD 1415-MOZ-24a-Y B-AWARD The O sponsors O of O the O study O had O no O role O in O study O design O data O collection O data O analysis O data O interpretation O or O writing O of O the O report O except O for O the O Agha O Kahn O Foundation O which O participated O in O the O study O design O and O data O collection O The O study O was O coordinated O by O the O Centro O de O Investigação O em O Saúde O de O Manhiça O CISM O Mozambique O in O collaboration O with O the O Universidade O Eduardo O Mondlane O Faculdade O de O Medicina O Maputo O Mozambique O and O the O Barcelona O Institute O for O Global O Health O ISGlobal)/Barcelona O Centre O for O International O Health O Research O Hospital O Clínic-Universitat O de O Barcelona O Spain O This O work O was O supported O by O the O Open B-ORG Financial I-ORG Grant I-ORG from I-ORG Qingdao I-ORG National I-ORG Laboratory I-ORG for I-ORG Marine I-ORG Science I-ORG and I-ORG Technology I-ORG No. O QNLM2016ORP0302 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 41376145 B-AWARD 41706155 B-AWARD the O Scientific B-ORG and I-ORG Technical I-ORG Innovation I-ORG Council I-ORG of I-ORG Shenzhen I-ORG No. O KQJSCX20170330110206042 B-AWARD the O Foundation B-ORG for I-ORG Distinguished I-ORG Young I-ORG Talents I-ORG in I-ORG Higher I-ORG Education I-ORG of I-ORG Guangdong I-ORG China I-ORG Grant O 2014KQNCX126 B-AWARD and O the B-ORG 62st-class I-ORG General I-ORG Financial I-ORG Grant I-ORG from I-ORG the I-ORG China I-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2017M622754 B-AWARD This O research O was O funded O by O the O NSFC O under O Grant O No. O U1836107 O 61602132 O 61562027 O and O 61572158 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Province I-ORG under O Grant O No. O 20181BAB202024 B-AWARD and O Education B-ORG Department I-ORG of I-ORG Jiangxi I-ORG Province I-ORG under O Grant O No. O GJJ170413 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2018M640368 B-AWARD Lau’s O work O is O supported O by O grants O from O the O RGC O of O the O Hong O Kong O SAR O Projects O CityU O 11502115 O and O CityU O 11525716 O the O NSFC B-ORG Basic I-ORG Research I-ORG Program I-ORG Project O 71671155 B-AWARD and O the O CityU O Shenzhen O Research O Institute O This O study O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81500431 B-AWARD 81770561 B-AWARD and O 81970499 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O BK20151039 B-AWARD Six B-ORG Talent I-ORG Peaks I-ORG Project I-ORG in I-ORG Jiangsu I-ORG Province I-ORG No. O 2018-WSW-003 B-AWARD and O Jiangsu O Province O Leading O Talents O and O Innovation O Team O No. O CXTDA2017033 O The O funding O agencies O did O not O have O a O role O in O the O design O of O the O study O or O the O collection O analysis O and O interpretation O of O data O This O work O was O supported O by O grants O from O theNational O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China(81900916),Beijing O Municipal I-ORG Administration I-ORG of I-ORG Hospitals’ I-ORG Youth I-ORG Programme(QML20190208 O thePriming O Scientific I-ORG Research I-ORG Foundation I-ORG for I-ORG the I-ORG Senior I-ORG Researcher I-ORG in I-ORG Beijing I-ORG TongRen I-ORG Hospital I-ORG Capital I-ORG Medical I-ORG University(2017-YJJ-GGL-005),10.13039/501100012166National O Key I-ORG R&D I-ORG Program I-ORG of I-ORG China(2018YFC0116800 O the O program O forChangjiang O Scholars I-ORG and I-ORG Innovative I-ORG Research I-ORG Team(IRT13082),Beijing O Scientific I-ORG and I-ORG Technological I-ORG Overall I-ORG Plan(Z171100000117002),10.13039/501100009331Beijing O Municipal I-ORG Administration I-ORG of I-ORG Hospitals I-ORG Clinical I-ORG Medicine I-ORG Development I-ORG of I-ORG Special I-ORG Funding I-ORG Support(XMLX201816),10.13039/501100004826Beijing O Natural I-ORG Science I-ORG Foundation(7194247 O Public O Welfare O Development O and O Reform O Pilot O Project O 2019-10 O andBeijing O Municipal I-ORG Administration I-ORG of I-ORG Hospitals I-ORG incubating I-ORG Program(PX20190007 O This O work O was O supported O by O grants O from O 1. O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81403110 B-AWARD URL:http://www.nsfc.gov.cn O 2. O Shanghai B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG grant O number O ZY3-CCCX-3-5001 B-AWARD URL:http://www.wsjsw.gov.cn/wsj O 3. O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG grant O number O 15DZ2292000 B-AWARD URL:http://www.stcsm.gov.cn O This O research O is O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No: O 61672124 B-AWARD the B-ORG Password I-ORG Theory I-ORG Project I-ORG of I-ORG the I-ORG 13th I-ORG FiveYear I-ORG Plan I-ORG National I-ORG Cryptography I-ORG Development I-ORG Fund I-ORG No: O MMJJ20170203 B-AWARD Liaoning B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Leading I-ORG Talents I-ORG Program I-ORG Project I-ORG No: O XLYC1802013 B-AWARD Key B-ORG R&D I-ORG Projects I-ORG of I-ORG Liaoning I-ORG Province I-ORG No: O 2019020105-JH2/103 B-AWARD and O Jinan B-ORG City I-ORG ‘20 I-ORG universities’ I-ORG Funding I-ORG Projects I-ORG Introducing I-ORG Innovation I-ORG Team I-ORG Program I-ORG No: O 2019GXRC031 B-AWARD to O XW. O This O work O was O funded O by O the O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2015CB755704 O to O HWM O the O Major B-ORG Research I-ORG Plan I-ORG of I-ORG Tianjin I-ORG 16YFXTsf00460 O to O HWM O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21390201 O and O 21621004 B-AWARD to O XMZ O the O Key B-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG ZDRW-ZS-2016-3 O to O HWM O the O National B-ORG Science I-ORG Foundation I-ORG for I-ORG Young I-ORG Scholars I-ORG of I-ORG China I-ORG 41306123 O to O WX O the B-ORG State I-ORG Key I-ORG R&D I-ORG project I-ORG of I-ORG China I-ORG 2016YFA0601101 O to O WX) O and O the O National O Science O Foundation O of O China O 91428308 O to O WX O Wellcome B-ORG Trust I-ORG 108433/Z/15/Z O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG BB/N00521X/1 O BB/N019172/1 B-AWARD BB/L024136/1 B-AWARD National B-ORG Science I-ORG Foundation I-ORG Division I-ORG of I-ORG Biological I-ORG Infrastructure I-ORG 1458808 O Intramural O Research O Program O of O the O National O Library O of O Medicine O at O National O Institutes O of O Health/DHHS O ELIXIR O the O research O infrastructure O for O life-science O data O the O European O Molecular O Biology O Laboratory O core O funds O Funding O for O open O access O charge O Wellcome O Trust O and O Research O Councils O UK O RCUK O Funding O for O this O work O was O provided O by O The O Perelman O School O of O Medicine O EAH O The B-ORG Charles I-ORG E I-ORG Kaufman I-ORG Foundation I-ORG Grant O KA2016_85225 B-AWARD to O EAH O The B-ORG Whitehall I-ORG Foundation I-ORG Grant O 2016-12-33 B-AWARD to O EAH O and O The B-ORG National I-ORG Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences I-ORG 5UL1TR000003 O GRG O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O work O was O supported O by O the O National O Key O R&D O Program O of O China O 2018YFC1604204-3 O the O National O First-class O Discipline O Program O of O Food O Science O and O Technology O JUFSTR20180302 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61378037 O the O Postdoctoral B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG of I-ORG China I-ORG 2019K241 O and O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0400402 O This O research O was O funded O by O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Pharmaceutical I-ORG Biotechnology I-ORG Nanjing I-ORG University O grant O number O “KF-202204” O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O “82074003” O the O Sichuan B-ORG Administration I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine O grant O number O “2022C010” O and O the O technology B-ORG innovation I-ORG research I-ORG and I-ORG development I-ORG project I-ORG of I-ORG Chengdu I-ORG Science I-ORG and I-ORG Technology I-ORG project O grant O number O “2021-YF05-00447-SN” O This O work O was O supported O by O the O Canada B-ORG Excellence I-ORG Research I-ORG Chairs I-ORG Government I-ORG of I-ORG Canada I-ORG photonics O innovation];Centre O National I-ORG de I-ORG la I-ORG Recherche I-ORG Scientifique I-ORG MI O I-AWARD µHPI];Fonds O de I-ORG Recherche I-ORG du I-ORG Québec I-ORG I-ORG Nature I-ORG et I-ORG Technologies I-ORG strategic O cluster];Natural O Sciences I-ORG and I-ORG Engineering I-ORG Research I-ORG Council I-ORG of I-ORG Canada I-ORG strategic O project I-AWARD grant];ANR O French I-ORG research I-ORG agency I-ORG ANR-12-SEED-0001 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O No. O 81702023 B-AWARD The O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grant O No. O BK20171049 B-AWARD Technology B-ORG Development I-ORG Foundation I-ORG of I-ORG Nanjing I-ORG Medical I-ORG University I-ORG Grant O No. O NMUB2018292 B-AWARD Jiangsu B-ORG Students’ I-ORG Platform I-ORG for I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Training I-ORG Program I-ORG Grant O No. O 201910312013Z B-AWARD This O study O were O funded O by O the O financial O support O of O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No: O 31271925 B-AWARD the O Special B-ORG Project I-ORG on I-ORG the I-ORG Integration I-ORG of I-ORG Industry I-ORG Education I-ORG and I-ORG Research I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG No: O 2013B090600015 B-AWARD and O the O Science I-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG China I-ORG No: O 2014J410019 B-AWARD This O paper O was O supported O by O the O Polish B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Higher I-ORG Education I-ORG Grants O Nos O 1883/P01/2007/32 B-AWARD IPY/25/2007 B-AWARD and O 3290/B/P01/2009/36 O Faculty B-ORG of I-ORG Biology I-ORG University I-ORG of I-ORG Gdańsk I-ORG 538-L120-B949-15 O and O Polish-Norwegian B-ORG Research I-ORG Fund I-ORG Grant O No. O PNRF-234-AI-1/07 B-AWARD Alkekonge O The O contribution O of O Agata O Weydmann-Zwolicka O was O supported O by O Grant O No. O 2017/27/B/NZ8/01056 B-AWARD from O the O National B-ORG Science I-ORG Centre I-ORG Poland I-ORG This O study O was O funded O by O scientific O research O program O of O the O Shanghai B-ORG Municipal I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG No. O 201540091 B-AWARD the O Innovation-oriented O Science O and O Technology O Grant O from O NPFPC B-ORG Key I-ORG Laboratory I-ORG of I-ORG Reproduction I-ORG Regulation I-ORG No.CX2017-5 O and O the O United B-ORG Nations I-ORG Population I-ORG Fund I-ORG Grant O No.PL-SSA20 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O study O design O and O clinical O data O collection O were O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81500732 B-AWARD The O statistical O analysis O was O supported O by O the O National O Natural O Science O Foundation O of O China O No. O 81700843 B-AWARD The O imageological O examination O was O supported O by O Bethune-Langmu B-ORG eye I-ORG research I-ORG fund I-ORG for I-ORG the I-ORG young I-ORG and I-ORG middle-aged I-ORG ophthalmologist I-ORG BJ-LM2018001J O The O manuscript O writing O and O polishing O were O supported O by O Shanghai B-ORG Pujiang I-ORG Program I-ORG No. O 16PJ1408500 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO. O 82204794 B-AWARD Medical B-ORG and I-ORG Health I-ORG Technology I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG NO. O 202002070917 B-AWARD and O Shandong B-ORG Province I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG NO. O 2020Q003 B-AWARD This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 51702227 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanxi I-ORG Province O China O Grant O No. O 201701D221071 B-AWARD and O China B-ORG Scholarship I-ORG Council I-ORG Grant O No.201706935017 O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51603090 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2018M630516 O Provincial O Policy O Guidance O Program O International O Scientific O and O Technological O Cooperation O No. O BZ2018032 O and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG JUSRP51907A O This O work O was O supported O in O part O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81600070 B-AWARD No. O 91442109 B-AWARD and O No. O 31470883 B-AWARD in O part O by O the O Beijing B-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospitals’ I-ORG Mission I-ORG Plan I-ORG No. O SML20150301 B-AWARD and O in O part O by O the O Chinese B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG for I-ORG the I-ORG establishment I-ORG of I-ORG GCP I-ORG evaluation I-ORG systems I-ORG in I-ORG respiratory I-ORG diseases I-ORG 2014ZX09303302 O This O study O was O funded O by O the B-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Freshwater I-ORG Ecology I-ORG and I-ORG Biotechnology I-ORG 2016FBZ08 O the B-ORG National I-ORG Major I-ORG Basic I-ORG Research I-ORG Program I-ORG 2015ZX07503-005-003 O the B-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Grant I-ORG QYZDY-SSW-SMC004 O and O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31400215 O This O work O was O supported O by O grants O from O theSwedish O Research I-ORG Council(2011-488,2013-3477 O theSwedish O Radiation I-ORG Safety I-ORG Authority(2012-2021,2013-2982 O theSwedish O Federal I-ORG Government I-ORG under I-ORG the I-ORG LUA/ALF I-ORG agreement(ALFGBG-136281,ALFGBG-428961 O and O theHealth O and I-ORG Medical I-ORG Care I-ORG Committee I-ORG of I-ORG the I-ORG Region I-ORG Västra I-ORG Götaland(VGFOUREG-81341,VGFOUREG-483951 O Funding O to O pay O the O Open O Access O publication O charges O for O this O article O was O provided O by O the O Swedish O Research O Council O This O work O was O supported O in O part O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81202032 O 81172140 I-AWARD 81272532 O by O the O Jiangsu B-ORG 233 I-ORG Province I-ORG Clinical I-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG Clinical O Research O Center O BL2012008 B-AWARD the O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG JX10231801 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31700319 B-AWARD 31870354 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No. O 2412017QD026 B-AWARD and O Project O funded O by O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2018M631852 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFB0305700 O the B-ORG Key I-ORG project I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Advanced I-ORG Welding I-ORG and I-ORG Joining I-ORG AWJ-19Z04 O International B-ORG Cooperation I-ORG Project I-ORG 2015DFA50470 O the B-ORG Qing I-ORG Lan I-ORG Project I-ORG Six I-ORG talent I-ORG peaks I-ORG project I-ORG in I-ORG Jiangsu I-ORG Province I-ORG XCL-022 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51475220 O This O project O was O funded O by O research O funds O from O a O competitive O grant O 155686 O from O the O Consejo B-ORG Nacional I-ORG de I-ORG Ciencia I-ORG y I-ORG Tecnología I-ORG CONACyT I-ORG awarded O to O J.F.O O the O Departamento B-ORG de I-ORG Biología I-ORG Evolutiva I-ORG INECOL I-ORG to O J.F.O O 20030/10563 O and O from O Universidad B-ORG Nacional I-ORG Autónoma I-ORG de I-ORG México I-ORG UNAM I-ORG PAPIIT I-ORG research I-ORG funds I-ORG IN217511 O IN216514 O to O M.C.A O S.D.I O was O supported O by O a O Master O of O Science O scholarship O from O CONACyT O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Research O reported O in O this O publication O was O supported O by O the O National B-ORG Institute I-ORG on I-ORG Drug I-ORG Abuse I-ORG awards O K99DA041494 O R00DA041494 B-AWARD 9K24DA040489 O the O National B-ORG Institute I-ORG on I-ORG Minority I-ORG Health I-ORG and I-ORG Health I-ORG Disparities I-ORG awards O P20MD002288 O U54MD002266 B-AWARD the O National B-ORG Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases I-ORG award O P30AI050409 O and O the O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health I-ORG awards O R01MH100021 O P30MH116867 B-AWARD of O the O National O Institutes O of O Health O The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O National O Institute O on O Drug O Abuse O the O National O Institute O on O Minority O Health O and O Health O Disparities O the O National O Institute O of O Allergy O and O Infectious O Diseases O the O National O Institute O of O Mental O Health O or O the O National O Institutes O of O Health O This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG C2019204270 O the O Science B-ORG and I-ORG Technology I-ORG Research I-ORG Project I-ORG of I-ORG the I-ORG Universities I-ORG of I-ORG Hebei I-ORG Province I-ORG QN2019159 O and O Research B-ORG Foundations I-ORG for I-ORG Returned I-ORG Scholars I-ORG from I-ORG Overseas I-ORG of I-ORG the I-ORG Human I-ORG Resources I-ORG Dept I-ORG of I-ORG Hebei I-ORG Province I-ORG C20190345 O Funds O were O used O for O the O design O of O the O study O sample O collection O analysis O or O interpretation O of O data O and O in O writing O the O manuscript O This O work O is O financially O supported O by O Key B-ORG Project I-ORG of I-ORG Science I-ORG I-ORG Technology I-ORG Research I-ORG of I-ORG Higher I-ORG Education I-ORG Institutions I-ORG of I-ORG Hebei I-ORG Province O China O ZD2018059 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2016M600190 O Innovation B-ORG I-ORG Entrepreneurship I-ORG Training I-ORG Program I-ORG of I-ORG Hebei I-ORG University I-ORG of I-ORG Technology I-ORG 201710080052 O and O Guangdong B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 2017A050506009 O This O work O was O supported O by O the O Danish O Council O for O Independent O Research O Sundhed O og I-ORG Sygdom I-ORG Det I-ORG Frie I-ORG Forskningsråd I-ORG DK O DFF-1333-00192 O Fonden O af O 17-12-1981 O DANIDA[grant B-ORG 104.Dan.8-920 B-AWARD and O European B-ORG Union I-ORG FP7 I-ORG support I-ORG for I-ORG OPTIMUNISE I-ORG grant O Health-F3-2011-261375 B-AWARD The O Bandim O Health O Project O received O support O from O Danish O National O Research O Foundation O Danmarks O Grundforskningsfond O via O support O to O CVIVA O grant O DNRF108 B-AWARD CSB O holds O a O starting O grant O from O the O European B-ORG Research I-ORG Council I-ORG grant O ERC-2009-StG-243149 B-AWARD SB O received O one O year O of O salary O from O Odense O University O Hospital O Odense O Universitetshospital O grant O A70 B-AWARD The O funding O agencies O had O no O role O in O the O collection O analysis O and O interpretation O of O data O in O the O writing O of O the O manuscript O and O in O the O decision O to O submit O the O article O for O publication O L.K O is O thankful O for O the O support O of O the O Natural O Science O Foundation O of O Jiangsu O Higher O Education O Institutions O of O China O Grant O No. O 17KJB180003 O the O Natural O Science O Foundation O of O Jiangsu B-ORG Normal I-ORG University I-ORG Grant O No. O 17XLR037 B-AWARD and O the O Jiangsu O Specially-Appointed O Professor O program O Y.Z O would O like O to O thank O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31471937 O for O their O support O This O work O is O supported O by O the O Deutsche B-ORG Forschungsgemeinschaft I-ORG grant O to O Ralf B-AWARD Kaldenhoff O This O work O is O also O part O of O the O MaxSynBio O consortium O which O is O jointly O funded O by O the O Federal O Ministry O of O Education O and O Research O of O Germany O and O the O Max O Planck O Society O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81902532 O 81904218 B-AWARD 82072773 B-AWARD and O 82203456 B-AWARD the O fellowship O of O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2022M712255 O and O the O Spark O Project O of O Sichuan B-ORG University I-ORG No. O 2082604401223 B-AWARD This O work O was O supported O by O Mega-projects B-ORG of I-ORG Science I-ORG Research I-ORG for I-ORG the I-ORG 12th I-ORG Five-Year I-ORG Plan I-ORG of I-ORG China I-ORG 2011ZX09401-007 O to O JS O National B-ORG Science I-ORG and I-ORG Technology I-ORG Infrastructure I-ORG Program I-ORG of I-ORG China I-ORG 2012BAI30B001 O to O JS O One B-ORG Hundred I-ORG Person I-ORG Project I-ORG of I-ORG The I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Applied I-ORG Basic I-ORG Research I-ORG Programs I-ORG of I-ORG Qinghai I-ORG Province I-ORG 2015-ZJ-733 O to O JS O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 81520108014 B-AWARD 81771800 B-AWARD and O 81829003 B-AWARD the O State’s B-ORG Key I-ORG Project I-ORG of I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG of I-ORG China I-ORG 2016YFA0201402 O and O the O International B-ORG Cooperation I-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG of I-ORG Sichuan I-ORG 2017HH0045 O This O work O is O supported O by O the B-ORG 863 I-ORG project I-ORG 2013AA102504 O the B-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG Programs I-ORG of I-ORG China I-ORG 2011BAD28B02 O National B-ORG Key I-ORG Technologies I-ORG R&D I-ORG Program I-ORG 2012BAD12B01 O Beijing B-ORG Dairy I-ORG Industry I-ORG Innovation I-ORG Team I-ORG China I-ORG Agricultural I-ORG Research I-ORG System I-ORG CARS-37 O and O Xinjiang B-ORG Province I-ORG Key I-ORG Technology I-ORG Integration I-ORG and I-ORG Demonstration I-ORG Program I-ORG 201230116 O We O are O deeply O grateful O to O all O donors O who O participated O in O this O program O The O funding O body O did O not O participate O in O the O design O of O the O study O and O collection O analysis O interpretation O of O data O or O in O writing O the O manuscript O This O work O is O supported O by O Public O Health O Service O grant O R01AI041757 B-AWARD from O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG and O a O grant O from O the O Xiamen B-ORG Southern I-ORG Oceanographic I-ORG Center I-ORG 17GYY002NF02 B-AWARD XW O wishes O to O acknowledge O support O from O the O Shenzhen B-ORG Committee I-ORG of I-ORG Scientific I-ORG and I-ORG Technical I-ORG Innovation I-ORG grant O JCYJ20150402102135492 B-AWARD ZL O is O supported O by O a O Tang O Pre-doctoral O Fellowship O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O South B-ORG African I-ORG National I-ORG Research I-ORG Foundation—Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Professional I-ORG Development I-ORG Programme I-ORG Doctoral O Grant O NRF O PDP I-AWARD Fellowship I-AWARD UID I-AWARD 88608 O N O Mahaye O N O Musee O the O Council B-ORG for I-ORG Scientific I-ORG and I-ORG Industrial I-ORG Research I-ORG CSIR I-ORG South I-ORG Africa I-ORG ECSD001 O N O Mahaye O and O the O Water B-ORG Research I-ORG Commission I-ORG WRC O K5/2509/1 O N O Musee O N O Mahaye O This O research O was O funded O by O grants O from O the O Convenio O de O Desempeño O en O Educación O Superior O Regional O UTA1795 B-AWARD MINEDUC O Chile O Proyecto O UTA B-AWARD Mayor I-AWARD 9728-20 I-AWARD Universidad O de I-ORG Tarapacá I-ORG Chile O and O Fondo B-ORG de I-ORG innovación I-ORG para I-ORG la I-ORG competitividad I-ORG regional I-ORG FIC-R O COD O BIP B-AWARD 400374240 O Año O 2021 O GORE O Arica O y O Parinacota O Chile O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 31571178 B-AWARD to O L.Y.Z O no. O 31771578 B-AWARD to O L.J.W O no. O 92068206 B-AWARD to O W.J.Z O The O work O was O also O supported O by O the B-ORG Guangdong I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG 2019B020234003 O to O W.J.Z O and O the O Guangdong B-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Precision I-ORG Medicine I-ORG for I-ORG Gastrointestinal I-ORG Cancer I-ORG 2020B121201004 O to O W.J.Z O This O work O was O funded O by O a O University B-ORG of I-ORG Leeds I-ORG 110 B-AWARD Anniversary I-AWARD Research I-AWARD Scholarship I-AWARD and O Wellcome B-ORG Trust I-ORG Institutional B-AWARD Strategic I-AWARD Support I-AWARD Fund I-AWARD Fellowship I-AWARD to O M.I.K O This O work O was O supported O by O the O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG NIHR O infrastructure O at O Leeds O The O views O expressed O are O those O of O the O authors O and O not O necessarily O those O of O the O National O Health O Service O the O NIHR O or O the O Department O of O Health O It O was O also O supported O by O a O GSK/Royal B-AWARD Academy I-ORG of I-ORG Engineering I-ORG Research I-AWARD Chairmanship I-AWARD to O N.K O and O an O NIHR O Research B-AWARD Professorship I-AWARD and O NIHR O Senior O Investigator O Award O to O D.G.J O The O study O was O supported O by O grants O from O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFC1308900 B-AWARD 2017YFC0908400 O which O help O the O writing O and O publication O of O the O manuscript O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O No. O 81371715 B-AWARD which O help O the O study O design O Beijing B-ORG Municipal I-ORG Science I-ORG I-ORG Technology I-ORG Commission I-ORG grant O No. O Z161100000516060 B-AWARD and O Beijing B-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospital’s I-ORG Youth I-ORG Program I-ORG QML20161102 O which O help O the O analysis O and O interpretation O of O data O This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0500800 O the B-ORG China I-ORG Agricultural I-ORG Research I-ORG System I-ORG CARS-42-17 O and O the B-ORG Sichuan I-ORG Veterinary I-ORG Medicine I-ORG and I-ORG Drug I-ORG Innovation I-ORG Group I-ORG of I-ORG China I-ORG Agricultural I-ORG Research I-ORG System I-ORG CARS-SVDIP O This O study O is O supported O in O part O by O grants O from O the O Ministry B-ORG of I-ORG Health I-ORG and I-ORG Welfare O Taiwan O MOHW107-TDU-B-212-123004 O Children’s B-ORG Hospital I-ORG of I-ORG China I-ORG Medical I-ORG University I-ORG DMR-106-052 O China B-ORG Medical I-ORG University I-ORG Hospital I-ORG DMR-107-026 O and I-AWARD DMR-107-176 O Academia B-ORG Sinica I-ORG Taiwan I-ORG Biobank I-ORG Stroke I-ORG Biosignature I-ORG Project I-ORG BM10701010021 O Taiwan B-ORG Clinical I-ORG Trial I-ORG Consortium I-ORG for I-ORG Stroke I-ORG MOST O 106-2321-B-039-005 O Tseng-Lien O Lin O Foundation O Taichung O Taiwan O Taiwan O Brain O Disease O Foundation O Taipei O Taiwan O and O Katsuzo O and O Kiyo O Aoshima O Memorial O Funds O Japan O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O Atherosclerosis O Risk O in O Communities O study O has O been O funded O in O whole O or O in O part O with O federal O funds O from O the O National B-ORG Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute I-ORG National I-ORG Institutes I-ORG of I-ORG Health I-ORG Department I-ORG of I-ORG Health I-ORG and I-ORG Human I-ORG Services O under O contract O nos O HHSN268201700001I B-AWARD HHSN268201700002I B-AWARD HHSN268201700003I B-AWARD HHSN268201700005I B-AWARD and O HHSN268201700004I B-AWARD Research O reported O in O this O publication O was O supported O by O the O National B-ORG Heart I-ORG Lung I-ORG And I-ORG Blood I-ORG Institute I-ORG of I-ORG the I-ORG National I-ORG Institutes I-ORG of I-ORG Health I-ORG under O Award O Number O K24HL148521 B-AWARD and O by O American B-ORG Heart I-ORG Association I-ORG grant O 16EIA26410001 B-AWARD Alonso O The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O National O Institutes O of O Health O The O study O was O supported O by O a O Maryland B-ORG Agriculture I-ORG Experimental I-ORG Station I-ORG Grant O MD-ENST-2956 B-AWARD USDA B-ORG Multistate I-ORG project O MD-ENST-1443 B-AWARD and O an O NSF-Couple B-ORG Natural I-ORG Human I-ORG Systems I-ORG Program I-ORG award O DEB-1211797 O to O Paul O T. O Leisnham O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Taiwan I-ORG grant O no. O MOST104-2320-B-037-018 B-AWARD url:http://www.most.gov.tw O to O PYC O Chi-Mei B-ORG Medical I-ORG Center I-ORG and I-ORG Kaohsiung I-ORG Medical I-ORG University I-ORG Research I-ORG Foundation I-ORG grant O no. O 103CM-KMU-06 B-AWARD URL:http://devel.kmu.edu.tw/index.php/en-GB O to O PYC O Center B-ORG for I-ORG Infectious I-ORG Disease I-ORG and I-ORG Cancer I-ORG Research I-ORG Kaohsiung I-ORG Medical I-ORG University I-ORG grant O no. O KMU-TP104E12 B-AWARD URL:http://devel.kmu.edu.tw/index.php/en-GB O to O YCT O Wei B-ORG Gong I-ORG Memorial I-ORG Hospital I-ORG grant O no. O 105-1-001 B-AWARD URL:http://www.weigong.org.tw/eng-index.html O to O PHC O and O Chi-Mei B-ORG Foundation I-ORG Medical I-ORG Center I-ORG grant O no. O CLFHR10127 B-AWARD URL:http://www.chimei.org.tw/main/clh_department/79052/index.htm O to O YCY O The O funders O had O no O role O in O the O design O of O the O study O the O collection O and O analysis O of O data O the O decision O to O publish O or O the O preparation O of O the O manuscript O This O research O was O funded O by O the O Scientific B-ORG Research I-ORG Foundation I-ORG of I-ORG Third I-ORG Institute I-ORG of I-ORG Oceanography I-ORG Ministry I-ORG of I-ORG Natural I-ORG Resources I-ORG grant O number O 2022024 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2021YFC3100503 O and O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 42106143 B-AWARD 42006098 B-AWARD 42006128 B-AWARD This O work O was O supported O by O grants O of O the O National O Institute O of O Health O NIH O National B-ORG Cancer I-ORG Institute I-ORG NCI O The O Ponce O Health O Sciences O University O and O Moffitt O Cancer O Center O Partnership O for O Excellence O in O Cancer O Research O U54 O grant O CA163071 B-AWARD for O BRCA O analysis O and O 1SC1CA182845 B-AWARD for O ancestry O and O haplotype O analyses O with O the O technical O support O of O the O Ponce O Research O Institute O Molecular O and O Genomics O Core O M.A.G.I.C O NIH-National O Institute I-ORG on I-ORG Minority I-ORG Health I-ORG and I-ORG Health I-ORG Disparities I-ORG NIMHD O MD007579 B-AWARD and O the O intramural O research O program O of O the O Division O of O Cancer O Epidemiology O and O Genetics O National O Cancer O Institute O National O Institutes O of O Health O Patient O recruitment O was O supported O by O grants O from O the O NIH-National O Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG NIGMS O S06-GM008239 O and O 9SC1CA182846 B-AWARD Study O also O partially O supported O by O The O University O of O Puerto O Rico O and O The O University O of O Texas O MD O Anderson O Cancer O Center O Partnership O for O Excellence O in O Cancer O Research O U54 O grant O CA096297/CA096300 B-AWARD from O the O NCI O NIH O San O Juan O cohort O H O Diaz-Zabala O received O a O fellowship O from O NIH-NIGMS O R25GM082406 O This O work O was O supported O financially O by O Natural B-ORG Resources I-ORG Development I-ORG Special I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grant O No. O JSZRHYKJ202113 B-AWARD National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 51908253 B-AWARD Zhenjiang B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG Project I-ORG Dantu I-ORG KeyResearch I-ORG and I-ORG Development I-ORG Plan I-ORG Project I-ORG Grant O No. O 2020106 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31801841 O Taishan B-ORG Scholar I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG tstp20221134 O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG Foundation I-ORG Grant O No. O CARS-27 B-AWARD The O project O was O supported O by O Science B-ORG and I-ORG Technology I-ORG Specific I-ORG Projects I-ORG in I-ORG Agricultural I-ORG High-tech I-ORG Industrial I-ORG Demonstration I-ORG Area I-ORG of I-ORG the I-ORG Yellow I-ORG River I-ORG Delta I-ORG 2022SZX34 O Graduate B-ORG innovation I-ORG program I-ORG of I-ORG Qingdao I-ORG Agricultural I-ORG University I-ORG QNYCX21039 O European O Molecular O Biology O Laboratory O Horizon B-ORG 2020 I-ORG Programme O of O the O European O Union O under O COMPARE O 643476 O EMBRIC B-ORG 654008 O ELIXIR-EXCELERATE B-ORG 676559 O UK O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG under O Metagenomics O Portal O II O BB/M011755/1 O Metagenomics O Portal O III O BB/R015228/1 O MG-RAST-EBI O BB/N018354/1 O RNA O Central O BB/N019199/1 O Gordon O and O Betty O Moore O Foundation O UniEuk O Funding O for O open O access O charge O European O Molecular O Biology O Laboratory O This O work O was O supported O by O State B-ORG Key I-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81330042 O Special B-ORG Program I-ORG for I-ORG Sino-Russian I-ORG Joint I-ORG Research I-ORG Sponsored I-ORG by I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG China I-ORG 2014DFR31210 O International B-ORG Cooperation I-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81620108018 O and O Key B-ORG Program I-ORG Sponsored I-ORG by I-ORG the I-ORG Tianjin I-ORG Science I-ORG and I-ORG Technology I-ORG Committee I-ORG China I-ORG 13RCGFSY19000 O 14ZCZDSY00044 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG project O No. O 6162014 B-AWARD Science B-ORG and I-ORG technology I-ORG project I-ORG of I-ORG Beijing I-ORG Municipal I-ORG Administration I-ORG Center I-ORG of I-ORG Parks I-ORG Project O NO. O zx B-AWARD 2018014 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG project O No. O 31870573 B-AWARD Each O fund O supports O the O experimental O material O cost O and O paper O revision O fee O etc O This O work O was O supported O by O grants O to O TTT O from O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo I-ORG FAPESP O grants O 2008/58106-0 B-AWARD and O 2014/13933-8 B-AWARD and O from O the O Brazilian B-ORG National I-ORG Council I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Development I-ORG CNPq O 477335/2009-8 B-AWARD and O by O a O grant O to O AMLAE O from O Fundação O de O Amparo O à O Pesquisa O FAPESP O grant O 2009/51723-7 B-AWARD GAC O and O RDM O were O supported O by O a O fellowship O from O FAPESP O 2009/13463-3 O and O 2014/01600-4 B-AWARD and O 2012/19987-7 B-AWARD respectively O MATM O received O a O fellowship O from O CNPq B-ORG and I-ORG FAPESP I-ORG 150441/2016-9 O and O 2012/23200-2 B-AWARD respectively O TTT O received O a O fellowship O from O CNPq O 307502/2011-2 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O U22A20142 B-AWARD the O Hebei B-ORG Province I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG No. O 20314305D B-AWARD China B-ORG Huaneng I-ORG Group I-ORG Co I-ORG Ltd I-ORG Headquarters I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG HNKJ20-H88 O This O project O was O sponsored O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Chongqing I-ORG China I-ORG grant O Nos O CSTC2019JCYJ-MSXMX0527 B-AWARD CSTC2018JCYJAX0382 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O No. O 31970484 B-AWARD and O Program B-ORG of I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG grant O No. O 2018FY100405 B-AWARD This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2016YFD0500707 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31872489 O Modern O Agro-Industry I-ORG Technology I-ORG Research I-ORG System I-ORG CARS-36 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O a O National B-ORG Institute I-ORG of I-ORG Environmental I-ORG Health I-ORG Sciences I-ORG Grant O No. O P42 B-AWARD ES010337 O OPT3 O transport O analyses O were O funded O by O the O Chemical B-ORG Sciences I-ORG Geosciences I-ORG and I-ORG Biosciences I-ORG Division I-ORG of I-ORG the I-ORG Office I-ORG of I-ORG Basic I-ORG Energy I-ORG Sciences I-ORG at I-ORG the I-ORG US I-ORG Department I-ORG of I-ORG Energy I-ORG DE-FG02-03ER15449 O Research O was O supported O by O a O US B-ORG National I-ORG Science I-ORG Foundation I-ORG Arabidopsis I-ORG 2010 I-ORG grant O IOB O 0419695 I-AWARD to O J.I.S O and O a O US B-ORG National I-ORG Science I-ORG Foundation I-ORG CAREER I-ORG grant O IOS-1252706 O to O D.G.M.C O D.G.M.C O also O received O support O from O the O University B-ORG of I-ORG Missouri I-ORG Research I-ORG Board I-ORG Grant O Project O CB000519).59Fe B-AWARD and35S-glutathione O experiments O were O supported O by O the O Department O of O Energy O Projects O for O Interrogations O of O Biological O Systems O DE-SC0002040 B-AWARD to O S.S O J O T.O.J O was O supported O by O the O UCSD-Salk B-ORG IGERT I-ORG Plant I-ORG Systems I-ORG Biology I-ORG Interdisciplinary I-ORG Graduate I-ORG Training I-ORG Program I-ORG Grant O No. O 0504645 B-AWARD and O D.W.D O by O the O NIH-NIBIB B-ORG Training I-ORG Grant I-ORG 5 O T32 I-AWARD EB004822 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81170807 O No.81873651 B-AWARD and O No.81972487 B-AWARD the O Major B-ORG Scientific I-ORG Research I-ORG Projects I-ORG of I-ORG Hunan I-ORG health I-ORG and I-ORG family I-ORG planning I-ORG commission I-ORG A2017011 O and O the O Scientific B-ORG Research I-ORG Fund I-ORG of I-ORG Education I-ORG Department I-ORG of I-ORG Hunan I-ORG Province I-ORG No.16B230 O The O funding O body O didn’t O have O any O role O in O the O design O collection O analysis O and O interpretation O of O data O or O in O the O writing O of O the O manuscript O This O work O was O financially O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31972271 O the B-ORG operational I-ORG funds I-ORG of I-ORG the I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Ecological I-ORG Pest I-ORG Control I-ORG for I-ORG Fujian-Taiwan I-ORG Crops I-ORG KEA17002A O the B-ORG Joint I-ORG International I-ORG Research I-ORG Laboratory I-ORG of I-ORG Ecological I-ORG Pest I-ORG Control I-ORG Educational O Ministry O of O China O KJG18018A O the B-ORG 111 I-ORG Program I-ORG in O China O KRA16001A O and O Science B-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG the I-ORG Fujian I-ORG Province I-ORG 2018NZ0002-1 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O by O The B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31471417 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2016M600466 O Specialized B-ORG Research I-ORG Fund I-ORG for I-ORG the I-ORG Doctoral I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG 20130101110104863 O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG LY15C130003 O This O study O was O funded O by O the O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG APP1042343 O University B-ORG of I-ORG Queensland I-ORG International I-ORG Scholarship I-ORG 44078179 O and O the O Excellent B-ORG Talents I-ORG Fund I-ORG Program I-ORG of I-ORG Peking I-ORG University I-ORG Health I-ORG Science I-ORG Center I-ORG BMU2017YJ002 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Analysis O of O morphology O in O this O work O was O carried O on O the O equipment O acquired O as O part O of O the O Innovative O Economy O Operational O Programme O conducted O by O the O Museum O and O Institute O of O Zoology O Polish O Academy O of O Sciences O Project O No. O WND-POIG.01.03.01-00-133/09 B-AWARD co-financed O by O the O European O Union O from O the O European B-ORG Regional I-ORG Development I-ORG Fund I-ORG 0.5 O The O technical O support O for O the O realization O of O this O work O was O also O provided O within O the O frame O of O the O project O ‘Centrum O of O Excellence O for O Parasitology’ O No. O 26220120022 B-AWARD supported O by O the O operating O program O ‘Research O and O Development’ O funded O by O the O European B-ORG Fund I-ORG for I-ORG Regional I-ORG Development I-ORG 0.4 O and O project O VEGA B-ORG 2/0013/16 B-AWARD 0.1 O This O work O was O supported O by O National B-ORG Science I-ORG Centre I-ORG Poland I-ORG 2013/09/N/ST8/00309 O Norwegian B-ORG Research I-ORG Council I-ORG 228415 O and O BMBF O Germany O GoBone O German-Polish I-ORG bilateral I-ORG project I-ORG 01DS16010A B-AWARD This O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31571120 O Shenzhen B-ORG Basic I-ORG Research I-ORG Project I-ORG JCYJ20180305124305294 O JCYJ20150729104249783 B-AWARD and O Guangdong-Government B-ORG Funding I-ORG for I-ORG Scientific I-ORG Research I-ORG 2015KCXTD009 O 2016KZDXM009 B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31440025 O Key B-ORG Projects I-ORG of I-ORG Natural I-ORG Science I-ORG Research I-ORG in I-ORG Anhui I-ORG Colleges I-ORG and I-ORG Universities I-ORG KJ2018A0339 O Fuyang B-ORG Normal I-ORG University I-ORG Research I-ORG Project I-ORG 2018HXXM21 O and O National B-ORG Training I-ORG Programs I-ORG of I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG for I-ORG Undergraduates I-ORG 201610371025 O This O work O was O supported O by O the O Clinical B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BL2012002 O the O Scientific B-ORG Research I-ORG Project I-ORG of I-ORG Nanjing I-ORG Province I-ORG 201402007 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20161385 O This O study O was O supported O by O grants O from O the B-ORG State I-ORG Commission I-ORG of I-ORG Science I-ORG I-ORG Technology I-ORG of I-ORG China I-ORG 2016YFC0104100 O the B-ORG Jiangsu I-ORG Province I-ORG Science I-ORG I-ORG Technology I-ORG Department I-ORG BE2018618 O and O the B-ORG Nanjing I-ORG Medical I-ORG Science I-ORG and I-ORG Technique I-ORG Development I-ORG Foundation I-ORG QRX17174 O We O thank O the O patients O for O their O participation O help O and O time O in O assisting O with O this O study O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82172256 O 92169105 I-AWARD 81861138044 I-AWARD and I-AWARD M-0060 O the O National B-ORG Scientific I-ORG and I-ORG Technological I-ORG Major I-ORG Project I-ORG of I-ORG China I-ORG 2017ZX10202203 O and O the O Hubei B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2022CFB565 O This O work O was O supported O in O part O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O No. O 61701197 B-AWARD and O 62161052 B-AWARD in O part O by O the O open O research O fund O of O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Integrated I-ORG Services I-ORG Networks I-ORG under O Grant O No. O ISN23-11 B-AWARD in O part O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG under O Grant O No. O 2021YFA1000500(4 B-AWARD in O part O by O in O part O by O National B-ORG Social I-ORG State I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O No. O 21XSH007 B-AWARD in O part O by O Yunnan B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O No. O 202201AT070021 B-AWARD in O part O by O the B-ORG 111 I-ORG Project I-ORG under O Grant O No. O B23008 B-AWARD in O part O by O the O project O of O Changzhou B-ORG Key I-ORG Laboratory I-ORG of I-ORG 5G+ I-ORG Industrial I-ORG Internet I-ORG Fusion I-ORG Application I-ORG under O Grant O No. O CM20223015 B-AWARD This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 81600402 B-AWARD 81470788 B-AWARD the O Project B-ORG of I-ORG Key I-ORG Laboratory I-ORG of O the O Education O Department O of O Liaoning O Province O grant O number O LS201601 B-AWARD and O the O Outstanding B-ORG Scientific I-ORG Fund I-ORG of I-ORG Shengjing I-ORG Hospital I-ORG grant O number O 201502 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0100301 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31671602 O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG and I-ORG the I-ORG Cooperation I-ORG and I-ORG Innovation I-ORG Mission I-ORG CAAS-ZDXT2018001 O and O the O National O Natural O Science O Foundation O of O China O 31301285 O This O work O was O supported O by O the O Medical B-ORG Research I-ORG Council I-ORG grant O MR/L009226/1 B-AWARD the O Comprehensive O Biomedical O Research O Centre O at O Imperial O College O London O of O the O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG grant O P45272 B-AWARD Imperial O National O Health O Service O Trust O and O by O the O Genesis B-ORG Research I-ORG Trust I-ORG grant O P51389 B-AWARD This O research O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG No. O 2020JQ-056 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2019M663700 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities O Xi’an O Jiaotong O University O China O No. O sxxj022019024 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51675242 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20180873 O the O University B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG 18KJB460006 O and O the O Jiangsu O Key O Laboratory O of O Precision O and O Micro-Manufacturing O Technology O This O work O was O supported O by O grants O from O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 O Program O No. O 2014CB542300 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31271378 O the O Research B-ORG Special I-ORG Fund I-ORG for I-ORG Public I-ORG Welfare I-ORG Industry I-ORG of I-ORG Health I-ORG No. O 201302018 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O BE2016737 O This O project O is O funded O by O the O National B-ORG Key I-ORG R I-ORG I-ORG D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0500804 O A O Key O Project O of O Anhui B-ORG Province I-ORG Education I-ORG Department I-ORG No: O KJ2016A822 O and O the B-ORG Program I-ORG of I-ORG Anhui I-ORG Science I-ORG and I-ORG Technology I-ORG University I-ORG No: O ZRC2016497 O This O research O was O supported O by O the B-ORG National I-ORG Major I-ORG Scientific I-ORG Equipment I-ORG program I-ORG grant O no. O 2012YQ12008003 B-AWARD China O and O the B-ORG Special I-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG Health I-ORG Professions I-ORG grant O no. O 201302015 B-AWARD China O The O authors O were O supported O by O the B-ORG Shanghai I-ORG Committee I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG grant O no. O 13430710500 B-AWARD China O the B-ORG New I-ORG Technology I-ORG Research I-ORG Project I-ORG Shanghai I-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG SHDC12014114 O and I-AWARD 2013SY058 O and O the B-ORG Shanghai I-ORG Natural I-ORG Science I-ORG Foundation I-ORG no. O 14ZR1405400 B-AWARD The O funders O had O no O role O in O the O design O and O conduct O of O the O study O collection O management O analysis O and O interpretation O of O the O data O preparation O review O or O approval O of O the O manuscript O and O decision O to O submit O the O manuscript O for O publication O This O research O was O supported O by O The O Natural B-ORG science I-ORG foundation I-ORG of I-ORG Qinghai I-ORG province I-ORG 2020-ZJ-965Q O The B-ORG open I-ORG project I-ORG of I-ORG Qinghai I-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Animal I-ORG Ecological I-ORG Genomics O Xining O QHEG-2019-04 O The B-ORG Chunhui I-ORG project I-ORG of I-ORG the I-ORG ministry I-ORG of I-ORG education I-ORG 2016CH04 O This O study O was O funded O in O part O by O grants O from O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG the I-ORG Taiwanese I-ORG Government I-ORG MOST-103-2314-B-016-021 O the O National B-ORG Defense I-ORG Medical I-ORG Research I-ORG MAB-104-008 O and O the O Teh-Tzer B-ORG Study I-ORG Group I-ORG for I-ORG Human I-ORG Medical I-ORG Research I-ORG Foundation I-ORG A1011070 O A1021012 I-AWARD and I-AWARD A1031056 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81774358 O Fok B-ORG Ying-Tong I-ORG Education I-ORG Foundation I-ORG of I-ORG China I-ORG No.151042 O Pearl B-ORG River I-ORG Scholars I-ORG Department I-ORG of I-ORG Education I-ORG Guangdong I-ORG Province I-ORG Guangdong O teacher's I-AWARD letter[2017]number79 O Scientific B-ORG Research I-ORG Team I-ORG Training I-ORG Project I-ORG of I-ORG GZUCM(2019KYTD202 O Guangzhou B-ORG Univ I-ORG Chinese I-ORG Med I-ORG Planning[2019]5 O XK2019016 I-AWARD This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Beijing I-ORG Municipality I-ORG Grant O No. O 4184098 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 61801022 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2016YFE0131500 B-AWARD the O Civil O Space O Project O of O China O Grant O No. O D040301 O the O International O Science O and O Technology O Cooperation O Special O Project O of O Beijing O Institute O of O Technology O Grant O No. O GZ2018185101 O and O the O Beijing O Excellent O Talents O Cultivation O Project O O Youth O Backbone O Individual O Project O We O are O grateful O for O financial O support O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31501253 O Jiangsu B-ORG Collaborative I-ORG Innovation I-ORG Center I-ORG for I-ORG Modern I-ORG Crop I-ORG Production I-ORG JCIC-MCP O and O the O Special B-ORG Fund I-ORG for I-ORG Agro-scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG 201503109 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O under O a O U-01 O grant O from O the O National B-ORG Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute I-ORG NHLBI O of O the O National O Institutes O of O Health O NIH O U01HL143505 O Dr. O Peltan O received O additional O support O from O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG K23GM129661 O Dr. O Knighton O received O additional O support O from O the O National B-ORG Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences I-ORG of O the O National O Institutes O of O Health O KL2TR002539 O The O funding O bodies O were O not O involved O in O the O study O and O collection O analysis O or O interpretation O of O the O data O in O writing O the O manuscript O This O work O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFC0804503 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51574276 I-AWARD and I-AWARD No. I-AWARD 51675536 O the O National B-ORG Postdoctoral I-ORG Program I-ORG for I-ORG Innovative I-ORG Talents I-ORG No. O BX20190386 B-AWARD China O Postdoctoral O Science O Foundation O funded O project O 2019M662461 O the O Major O National O Science O and O Technology O Program O No. O 2016ZX05028-001-05 O the O Fundamental O Research O Funds O for O the O Central O Universities O 18CX05017A O and O Shandong O Province O Key O Research O and O Development O Plan O No. O 2018GHY115026 O This O study O was O funded O in O part O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG K07 O CA115687 O R01 B-AWARD CA127435 O P01 B-AWARD CA87969 O UM1 B-AWARD CA186107 O UM1 B-AWARD CA167552 O R01 B-AWARD CA149445 O R21 B-AWARD CA198239 O F32 B-AWARD CA220859 O K99 B-AWARD CA215314 O R03 B-AWARD CA204825 O and O the O American B-ORG Cancer I-ORG Society I-ORG MRSG-17–220-01–NEC O RSG-11–020-01-CNE B-AWARD PF-17–231-01-CCE B-AWARD and O Clinical O Research O Professorship O GAC O and O institutional O funds O from O the O Dana-Farber O Cancer O Institute O This O research O was O also O supported O by O a O Stand O Up O To O Cancer B-ORG Dream I-ORG Team I-ORG Research I-ORG Grant O grant O number O SU2C-AACR-DT-28-18 B-AWARD Stand O Up O To O Cancer O is O a O program O of O the O Entertainment O Industry O Foundation O Research O grants O are O administered O by O the O American O Association O for O Cancer O Research O the O scientific O partner O of O Stand O Up O To O Cancer O Opinions O interpretations O conclusions O and O recommendations O are O those O of O the O authors O and O are O not O necessarily O endorsed O by O Stand O Up O To O Cancer O the O Entertainment O Industry O Foundation O or O the O American O Association O for O Cancer O Research O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 22005222 O Science B-ORG Foundation I-ORG for I-ORG High-Level I-ORG Talents I-ORG of I-ORG Wuyi I-ORG University I-ORG 2019AL022 O and O 5041700133 B-AWARD Basic B-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG of I-ORG Jiangmen I-ORG JZ202212 O Guangdong B-ORG province I-ORG innovation I-ORG and I-ORG strong I-ORG school I-ORG project I-ORG 2020ZDZX2004 O and O 2020KQNCX087 B-AWARD Joint B-ORG Science I-ORG Foundation I-ORG of I-ORG Wuyi I-ORG University I-ORG and I-ORG HK I-ORG and I-ORG Macao I-ORG 2019WGALH14 O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG 2022A1515110136 O and O Innovation B-ORG Foundation I-ORG of I-ORG Educational I-ORG Com-mission I-ORG Guangdong I-ORG Province I-ORG 2020KQNCX090 O This O research O was O funded O by O the O Austrian B-ORG Science I-ORG Fund I-ORG grant O SFB B-AWARD F4606-B28 I-AWARD and O RB O by O the O Swiss O Messerli O Research O Foundation O Sörenberg O Switzerland O The O authors O acknowledge O support O from O Cancer B-ORG Research I-ORG UK I-ORG C30122/A11527 O C30122/A15774 B-AWARD CRUK//NIHR O in O England/DoH O for O Scotland O Wales O and O Northern O Ireland O Experimental O Cancer O Medicine O Centre O C10355/A15587 O the O Medical B-ORG Research I-ORG Council I-ORG MR/L023091/1 O the O Cancer O Research O UK O King’s O Health O Partners O Centre O at O King’s O College O London O C604/A25135 O and O Breast O Cancer O Now O 147 O KCL-BCN-Q3 O working O in O partnership O with O Walk O the O Walk O The O research O was O supported O by O the O National O Institute O for O Health O Research O NIHR O Biomedical O Research O Centre O BRC O based O at O Guy’s O and O St O Thomas’ O NHS O Foundation O Trust O and O King’s O College O London O IS-BRC-1215-20006 O The O authors O are O solely O responsible O for O study O design O data O collection O analysis O decision O to O publish O and O preparation O of O the O manuscript O The O views O expressed O are O those O of O the O author(s O and O not O necessarily O those O of O the O NHS O the O NIHR O or O the O Department O of O Health O This O work O was O supported O by O theProjects O of I-ORG Parallel I-ORG Variation I-ORG Calling I-ORG Tools(902015CA0250),ENCODE O of I-ORG Tobacco I-ORG Genome(110201601033 O JY-07 O and O theYoung O Elite I-ORG Scientists I-ORG Sponsorship I-ORG Programby O CAST O 2016QNRC001 O This O study O was O financially O supported O by O the O GDAS B-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG 2019GDASYL-0502003 O 2019GDASYL-0103024 O and O the O Project O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31660181 O and O the O Educational B-ORG Commission I-ORG of I-ORG Hunan I-ORG Province I-ORG of I-ORG China I-ORG 16A175 O and O the O National B-ORG I-ORG local I-ORG United I-ORG Engineering I-ORG Laboratory I-ORG of I-ORG Integrative I-ORG Utilization I-ORG Technology I-ORG of I-ORG Eucommia I-ORG ulmoides I-ORG NLE201602 O and I-AWARD NLE201704 O This O work O was O supported O by: O GRD O and O MLF-PICT O 2015-1354-Agencia O Nacional I-ORG de I-ORG Promoción I-ORG Científica I-ORG y I-ORG Tecnológica-https://www.argentina.gob.ar/ciencia/agencia O GRD O and O MLF O PIP O Nº0854-2015-Consejo O Nacional I-ORG de I-ORG Investigaciones I-ORG Científicas I-ORG y I-ORG Técnicas I-ORG https://www.conicet.gov.ar O GRD O and O MLF O UNMdP O EXA B-AWARD 762/16 O Universidad B-ORG Nacional I-ORG de I-ORG Mar I-ORG del I-ORG Plata-http://www.mdp.edu.ar O MLF O is O an O established O researcher O from O CONICET O Consejo O Nacional O de O Investigaciones O Científicas O y O Técnicas O GRD O is O an O established O researcher O from O CIC O Comisión O de O Investigaciones O Científicas O MFRB O is O a O post-doctoral O fellow O from O Agencia O Nacional O de O Promoción O Científica O y O Tecnológica O The O Key B-ORG Project I-ORG of I-ORG University I-ORG Humanities I-ORG and I-ORG Social I-ORG Science I-ORG Research I-ORG in I-ORG Anhui I-ORG Province I-ORG SK2017A0191 O was O granted O by O Education O Department O of O Anhui O Province O the O Research B-ORG Project I-ORG of I-ORG Anhui I-ORG Province I-ORG Social I-ORG Science I-ORG Innovation I-ORG Development I-ORG 2018XF155 O was O granted O by O Anhui O Provincial O Federation O of O Social O Sciences O the O Ministry B-ORG of I-ORG Education I-ORG Humanities I-ORG and I-ORG Social I-ORG Sciences I-ORG Research I-ORG Youth I-ORG fund I-ORG Project I-ORG 17YJC840033 O was O granted O by O Ministry O of O Education O of O the O People’s O Republic O of O China O These O funders O had O a O role O in O study O design O text O editing O interpretation O of O results O decision O to O publish O and O preparation O of O the O manuscript O Research O reported O in O this O publication O was O supported O by O the O National B-ORG Center I-ORG for I-ORG Complementary I-ORG and I-ORG Integrative I-ORG Health I-ORG of I-ORG the I-ORG National I-ORG Institutes I-ORG of I-ORG Health I-ORG under O award O number O R00AT006507 B-AWARD CAPES B-ORG Foundation I-ORG Process O No. O 2339-15-3 B-AWARD and O FAPESP B-ORG Process O No. O 2012/02885-7 B-AWARD from O whom O the O first O author O received O a O scholarship O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Centre I-ORG for I-ORG the I-ORG Replacement I-ORG Refinement I-ORG and I-ORG Reduction I-ORG of I-ORG Animals I-ORG in I-ORG Research I-ORG grant O numbers O NC/R001596/1 B-AWARD to O Y.L O B.D.R O S.M.N O and O P.R.L O and O NC/W002264/1 B-AWARD to O M.A O the O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG grant O number O BB/S005846/1 B-AWARD to O Y.L O and O P.R.L O and O the O Medical B-ORG Research I-ORG Council I-ORG grant O number O MR/P028225/1 B-AWARD MRC O CMBI O including O to O B.D.R O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81672054 O and O 81871688 B-AWARD the O Research B-ORG Team I-ORG Programme I-ORG of I-ORG the I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG 2014A030312016 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017A030313120 O and O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG 201807010005 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31802210 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M630615 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20180911 O the O Natural O Science O Foundation O of O the O Jiangsu O Higher O Education O Institutions O of O China O 18KJB230007 O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31870015 O 31300016 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Development I-ORG Program I-ORG of I-ORG Jilin I-ORG Province I-ORG No. O 20180101273JC B-AWARD the O Program B-ORG of I-ORG Creation I-ORG and I-ORG Utilization I-ORG of I-ORG Germplasm I-ORG of I-ORG Mushroom I-ORG Crop I-ORG of I-ORG the I-ORG “111” I-ORG Project I-ORG No. O D17014 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Research I-ORG Programs I-ORG of I-ORG the I-ORG Education I-ORG Department I-ORG of I-ORG Jilin I-ORG Province I-ORG in I-ORG the I-ORG Thirteenth I-ORG Five–Year I-ORG Plan I-ORG No. O JJKH20180671KJ B-AWARD Author O Chuangqi O Wei O received O funding O from O Hebei B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O No. O C2020301024 B-AWARD Author O Junfeng O Guan O received O funding O from O Key B-ORG R I-ORG I-ORG D I-ORG plan I-ORG of I-ORG Hebei I-ORG province I-ORG 22327505D O and O HAAFS B-ORG Agriculture I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG 2022KJCXZX-SSS-3 O Funding O for O this O study O was O made O possible O by O a O grant O from O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH O R01 B-AWARD CA127296 O The O Neighborhood O Quality O of O Life O Study O NQLS O for O the O US O sites O was O supported O by O an O NIH O Grant O HL67350 O The O UK O study O was O funded O by O the O Medical B-ORG Research I-ORG Council I-ORG Grant O 75376 B-AWARD under O the O National O Preventive O Research O Initiative O Data O collection O in O New O Zealand O was O supported O by O the O Health B-ORG Research I-ORG Council I-ORG of I-ORG New I-ORG Zealand I-ORG Grant O 07/356 B-AWARD Funding O for O the O study O in O Denmark O was O partially O supplied O by O the O Municipality O of O Aarhus O Australian O data O collection O was O supported O by O the O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG NHMRC O of O Australia O Grant O 213114 B-AWARD Ester O Cerin O is O supported O by O an O Australian B-ORG Research I-ORG Council I-ORG Future I-ORG Fellowship I-ORG FT O 140100085 O This O work O was O funded O by O CONICYT B-ORG PFB I-ORG 23/2008 B-AWARD and O ICM B-ORG P05-002 B-AWARD through O the O Instituto O de O Ecología O O Biodiversidad O IEB-Chile O Luis O E. O Castañeda O was O funded O by O Fondo B-ORG Nacional I-ORG de I-ORG Desarrollo I-ORG Cientifico I-ORG y I-ORG Tecnológico I-ORG grant O 1140066 B-AWARD Chile O RS O received O a O CONICYT B-ORG doctoral I-ORG scholarship I-ORG and O a O PAI B-AWARD T7816110001 I-AWARD grant O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Funding O for O this O study O includes O The B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0105502 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81527901 O and O Beijing B-ORG New-star I-ORG Plan I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG Z181100006218129 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O 51673013 B-AWARD Scientific B-ORG Research I-ORG Starting I-ORG Foundation I-ORG PXM2019_014213_000007 O and O Russian B-ORG Science I-ORG Foundation I-ORG grant O 19-79-30091 B-AWARD This O study O was O supported O by O Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG 16411962700 O Shanghai B-ORG Municipal I-ORG Planning I-ORG Commission I-ORG of I-ORG Science I-ORG and I-ORG Research I-ORG Fund I-ORG 2017BR049 O Shanghai O Municipal O Planning O Commission O of O Science O and O Research O Fund O 20134026 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81670464 O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81460416 O 81560399 B-AWARD the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2012AA02A503 O and O the O Scientific B-ORG Research I-ORG Start-up I-ORG Capital I-ORG for I-ORG High-level I-ORG Talents I-ORG of I-ORG Shihezi I-ORG University I-ORG RCZX201444 O RCZX201229 B-AWARD This O research O was O supported O by O the O National B-ORG Key I-ORG Technology I-ORG R&D I-ORG Program I-ORG 2015BAD16B02 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 31471718 B-AWARD 1701722 B-AWARD the O Modern B-ORG Agricultural I-ORG Industry I-ORG Technology I-ORG System I-ORG CARS-30 O and O Key B-ORG research I-ORG and I-ORG development I-ORG plan I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 2017ZDXL-NY-0304 O The O work O of O Andrés O J. O Gutiérrez-Escobar O was O supported O by O Colciencias B-ORG grant O 599-2014 B-AWARD the O work O of O Maria O M O Bravo O was O supported O by O the O grant O 41030610588 B-AWARD of O Instituto B-ORG Nacional I-ORG de I-ORG Cancerología I-ORG and O the O work O of O Steffen O Backert O is O supported O by O DFG B-ORG grant O A04 B-AWARD in I-AWARD CRC-1181 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O by O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of O China O No. O 81670299 B-AWARD Shanghai B-ORG Shenkang I-ORG Medicine I-ORG Developing I-ORG Project I-ORG SHDC12014107 O Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Committee I-ORG Medicine I-ORG Leading I-ORG Project I-ORG No. O 15411960100 B-AWARD Shanghai B-ORG Leading I-ORG Talent I-ORG Program I-ORG LJRC-WZN O and O PLA B-ORG Medical I-ORG Scientist I-ORG Cultivation I-ORG Program I-ORG 17QNP013 O This O work O was O supported O by O the O grant O of O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2021YFA0909600 O to O X.S O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31670053 O to O X.S O 32000022 B-AWARD to O H.G O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2019M663829 O to O H.G O and O Northwest B-ORG A&F I-ORG University I-ORG starting I-ORG research I-ORG fund I-ORG Z1090219039 O to O H.G O This O work O was O supported O by O Jiangsu B-ORG Academy I-ORG of I-ORG Agricultural I-ORG Innovation I-ORG funds I-ORG CX O 15) I-AWARD 1044 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 31201556 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK2012373 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32101032 O 81991522 B-AWARD Shandong B-ORG Provincial I-ORG Major I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 2021ZDSYS22 O 2020CXGC010601 B-AWARD Major B-ORG Project I-ORG of I-ORG Qingdao I-ORG National I-ORG Laboratory I-ORG for I-ORG Marine I-ORG Science I-ORG and I-ORG Technology I-ORG 2022QNLM030004-4 O Taishan B-ORG Scholar I-ORG Climbing I-ORG Project I-ORG TSPD20210304 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2021QC110 O This O work O was O supported O by O Quality B-ORG Inspection I-ORG Public I-ORG Welfare I-ORG Program I-ORG of I-ORG China I-ORG 201410020 B-AWARD http://www.aqsiq.gov.cn O YY, O National B-ORG key I-ORG R I-ORG I-ORG D I-ORG plan[2016YFC1202700 O http://www.most.gov.cn O YY,CAIQ O project[2016JK031 O http://www.caiq.org.cn O YY. O The O funders O paid O all O the O fee O in O the O study O design,data O collection O and O analysis,decision O to O publish O the O manuscript O This O work O was O supported O by O the O Medical B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG grant O number O A2017404 B-AWARD Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Meizhou I-ORG grant O number O 2018B024 B-AWARD Key B-ORG Scientific I-ORG and I-ORG Technological I-ORG Project I-ORG of I-ORG Meizhou I-ORG People’s I-ORG Hospital I-ORG grant O number O MPHKSTP-20180101 B-AWARD Key O Scientific O and O Technological O Project O of O Meizhou O People’s O Hospital O grant O number O MPHKSTP-20170102 B-AWARD V.C O M.P.C O and O B.I O thank O the O Universidad B-ORG del I-ORG Valle I-ORG CIAM-2017 O COLCIENCIAS B-ORG 110680864255 O and O the O Science O Technology O and O Innovation O Fund-General O Royalties O System O FCTeI-SGR O under O contract O BPIN O 2013000100007 O Colombia O M.-J.P.-P O E.-M.P O and O M.-J.C O acknowledge O the O financial O support O of O SAF2015-64629-C2-1-R O and O CSIC-PIE-201680E079 B-ORG This O study O was O financed O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81802821 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2017A030310547 B-AWARD and O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Nos O 32018T110859 O and I-AWARD 2017M612636 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O research O is O supported O by: O Annual B-ORG Project I-ORG of I-ORG Shaanxi I-ORG Social I-ORG Science I-ORG Fund I-ORG “Research I-ORG on I-ORG Public I-ORG Art I-ORG Intervention I-ORG Path I-ORG Based I-ORG on I-ORG Rural I-ORG Spatial I-ORG Cultural I-ORG Identity I-ORG in I-ORG Guanzhong I-ORG Area” I-ORG Project O No O 2021J047 B-AWARD Special B-ORG scientific I-ORG Research I-ORG Project I-ORG of I-ORG Education I-ORG Department I-ORG of I-ORG Shaanxi I-ORG Province I-ORG Systematic I-ORG design I-ORG of I-ORG cultural I-ORG and I-ORG creative I-ORG products I-ORG of I-ORG red I-ORG Culture I-ORG tourism I-ORG in I-ORG northern I-ORG Shaanxi I-ORG project I-ORG Project O No O 20JK0076 B-AWARD Project B-ORG of I-ORG Shaanxi I-ORG Province I-ORG to I-ORG improve I-ORG public I-ORG Science I-ORG Quality I-ORG Project O No O 2021PSL131 B-AWARD This O work O was O supported O by O theNational O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China(21401065 O the O Science O Project O ofEducation O Department I-ORG of I-ORG Anhui I-ORG Province(KJHS2018B04 O and O theProvincial O Undergraduate I-ORG Innovation I-ORG Project(201710375012 O 201810375092 B-AWARD 201810375112 B-AWARD This O work O was O supported O by O the B-ORG 973 I-ORG Program I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2015CB150601 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31371263 O 31860021 B-AWARD and O the B-ORG Ba I-ORG Gui I-ORG Scholar I-ORG Program I-ORG of I-ORG Guangxi I-ORG Zhuang I-ORG Autonomous I-ORG Region I-ORG of I-ORG China I-ORG 2014A002 O The O funding O bodies O had O no O role O in O the O design O of O the O study O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O The O research O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31772591 O the O Modern B-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG CARS-41 O and O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG ASTIP-IAS04 O ASTIP-IAS-TS-15 B-AWARD This O work O was O supported O by O Zhejiang B-ORG Commonweal I-ORG Research I-ORG Program I-ORG of I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2017C37136 O which O helped O with O the O design O of O the O experiment O and O paper O writing O the O Medicine B-ORG and I-ORG Health I-ORG Care I-ORG in I-ORG Zhejiang I-ORG Province I-ORG General I-ORG Studies I-ORG Program I-ORG 2016KYB260 O which O helped O with O data O collection O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Ningbo I-ORG Municipality I-ORG 2017A610177 O 2017A610210 B-AWARD which O helped O with O flow O cytometry O data O analysis O This O research O was O supported O by O Yunnan B-ORG Provincial I-ORG Key I-ORG Fund I-ORG Program I-ORG 2010CC002 O Middle-aged B-ORG and I-ORG Young I-ORG Academic I-ORG Leader I-ORG Training I-ORG Foundation I-ORG of I-ORG Yunnan I-ORG Province I-ORG 2014HB039 O and O International B-ORG Science I-ORG I-ORG Technology I-ORG Cooperation I-ORG Program I-ORG of I-ORG Yunnan I-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG 2014IA009 O The O writing O of O this O article O was O supported O by O Humanities B-ORG and I-ORG Social I-ORG Science I-ORG Foundation I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG 16JJD840011 O Guangzhou O 13th I-ORG Five I-ORG Year I-ORG Plan I-ORG in I-ORG Philosophy I-ORG and I-ORG Social I-ORG Science I-ORG 2016GZQN05 O and O Talent B-ORG Project I-ORG of I-ORG Guangzhou I-ORG 13th I-ORG Five I-ORG Year I-ORG Plan I-ORG in I-ORG Philosophy I-ORG and I-ORG Social I-ORG Science I-ORG 2017GZZK41 O The O funders O had O no O role O in O the O design O of O the O study O the O collection O analysis O and O interpretation O of O data O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31360640 B-AWARD and I-AWARD 314360692 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Inner I-ORG Mongolia I-ORG University I-ORG for I-ORG Nationalities I-ORG No. O NMDYB1705 B-AWARD and O Interdisciplinary B-ORG Program I-ORG for I-ORG Inner I-ORG Mongolia I-ORG University I-ORG for I-ORG Nationalities I-ORG MDXK008 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O Science B-ORG Foundation I-ORG for I-ORG Young I-ORG Scholars I-ORG of I-ORG Tobacco I-ORG Research I-ORG Institute I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG 2017B06 O and O the B-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG ASTIP-TRIC02 O and O China B-ORG Tobacco I-ORG Genome I-ORG Project I-ORG Grant O No.202013-KN274 O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation O China O Grant O No: O 51603163 B-AWARD Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Shaanxi O China O Grant O No: O 2017JQ5056 B-AWARD Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Textile I-ORG Industry I-ORG Association O China O Grant O No: O 2017041 B-AWARD Scientific O Research O Program O Funded O by O Shaanxi O Provincial O Education O Department O China O Grant O No: O 18JS041 B-AWARD Young O Talent O fund O of O University O Association O for O Science O and O Technology O in O Shaanxi O Province O China O Grant O No: O 20160123 B-AWARD Thousand O Talents O Program O of O Shaanxi O Province O and O Sanqin O Scholar O Foundation O of O Shaanxi O Province O China O This O work O was O supported O by O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. O LY14H040012 B-AWARD the B-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Zhejiang I-ORG Province I-ORG Nos O 2013C31066 B-AWARD 2018C37126 B-AWARD the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFC1001301 B-AWARD and O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81000244 B-AWARD 81771647 B-AWARD 81490742 B-AWARD 31471405 B-AWARD and O 81661128010 B-AWARD X.G O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFD0200400 B-AWARD and O 2011AA10A203 B-AWARD Project B-ORG of I-ORG Fujian-Taiwan I-ORG Joint I-ORG Center I-ORG for I-ORG Ecological I-ORG Control I-ORG of I-ORG Crop I-ORG Pests I-ORG Minjiaoke[2013]51 O X.P O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31601686 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG China I-ORG 2016J01112 O Fujian B-ORG Province I-ORG Education I-ORG Department I-ORG China I-ORG JA15156 O and O Science B-ORG Fund I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG of I-ORG Fujian I-ORG Agriculture I-ORG and I-ORG Forestry I-ORG University I-ORG China I-ORG Grant O xjq201719 B-AWARD Z.C O was O supported O by O the O National O Natural O Science O Foundation O of O China O 21607024 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31570647 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2572018CL05 O and O the O 111 B-ORG Project I-ORG B16010 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Y.Z O 82203353 B-AWARD the O Fellowship B-ORG of I-ORG China I-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Y.Z O 2022M723565 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG Y.Z O 2022JJ40851 B-AWARD and O the O Youth B-ORG Research I-ORG Foundation I-ORG of I-ORG Xiangya I-ORG Hospital I-ORG Central I-ORG South I-ORG University I-ORG Y.Z O 2021Q16 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81430004 O Tianjin B-ORG Clinical I-ORG Research I-ORG Center I-ORG for I-ORG Blood I-ORG Diseases I-ORG 15ZXLCSY00010 O and O CAMS B-ORG Initiative I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG 2016-I2M-1-001 O This O work O was O co-funded O by O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq O BR, O Grant O No O 305.991/2017–5 B-AWARD 432.001/2016–6 I-AWARD 304.872/2013–0 I-AWARD 307.664/2015–5 I-AWARD and I-AWARD 402.289/2013–7 O Fundação B-ORG Carlos I-ORG Chagas I-ORG Filho I-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG do I-ORG Rio I-ORG de I-ORG Janeiro I-ORG FAPERJ O BR, O Grant O No. O E-26/202.918/2015 O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo I-ORG FAPESP O Grant O No. O 2015/26233–7 B-AWARD and O Instituto B-ORG Nacional I-ORG de I-ORG Ciência I-ORG e I-ORG Tecnologia I-ORG de I-ORG Fármacos I-ORG e I-ORG Medicamentos I-ORG INCT-INOFAR O BR, O Grant O No O 465.249/2014 B-AWARD Thanks O are O also O due O to O Departamento B-ORG de I-ORG Ciência I-ORG e I-ORG Tecnologia I-ORG DECIT I-ORG of I-ORG Brazilian I-ORG Ministry I-ORG of I-ORG Health I-ORG for O the O financial O support O Grant O No O 25000.447435/2017–00 B-AWARD Support O was O provided O by: O MINECO B-ORG Grant O no. O BFU2014-59009-P B-AWARD to O VC; O CYTED B-ORG grant O no. O 214RT0482 B-AWARD to O VC; O and O NCN B-ORG grant O no O UMO-2012/07/B/ST5/01941 B-AWARD to O ZU-L O This O study O was O supported O by O funding O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81602645 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2018A030313292 O and O Research O Funds O from O Guangzhou B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 201804010430 O The O funding O body O has O no O roles O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan O China O grant O no. O 2017YFC0405102 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation O China O grant O no. O 11372281 B-AWARD and O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Structural I-ORG Analysis I-ORG for I-ORG Industrial I-ORG Equipment O Dalian O University O of O Technology O Dalian O 116024 O China O grant O no. O GZ18111 B-AWARD This O research O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20181401 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21878160 O and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2016YFD0600801 O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82172163 O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2021YFC2501800 O the O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG LY20H010002 O the O Zhejiang B-ORG Provincial I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG 2022ZQ055 O to O B.T O and O the O Zhejiang O Provincial O Natural O Science O Foundation O of O China O to O J.L O LY20H010003 O This O research O is O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NNSF O under O grant O 61471306 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Sichuan I-ORG Province I-ORG under O grant O 2022NSFSC0548 B-AWARD the O Key B-ORG R&D I-ORG Projects I-ORG of I-ORG Sichuan I-ORG Province I-ORG under O grant O 2020YFS0360 B-AWARD the O Natural O Science O Foundation O of O Sichuan O Province O under O grant O 2023NSFSC0505 B-AWARD Sponsored O by O Shanghai B-ORG Sailing I-ORG Program I-ORG Grant O No. O 17YF1415700 B-AWARD Shanghai B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Grant O No. O 2017BR043 B-AWARD Hospital B-ORG Development I-ORG Center I-ORG Grant O No. O 16CR2022A B-AWARD The O funding O bodies O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O the O writing O of O the O manuscript O This O study O was O funded O by O the O Ministry B-ORG of I-ORG Education I-ORG and I-ORG Science-Junta I-ORG de I-ORG Comunidades I-ORG de I-ORG Castilla-La I-ORG Mancha I-ORG PII1I09-0259-9898 O and I-AWARD POII10-0208-5325 O and O Ministry B-ORG of I-ORG Health I-ORG FIS O PI081297 O Additional O funding O was O obtained O from O the O Research B-ORG Network I-ORG on I-ORG Preventative I-ORG Activities I-ORG and I-ORG Health I-ORG Promotion I-ORG Ref O RD06/0018/0038 O The O founders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2018A030313622 O the O Open B-ORG Project I-ORG Program I-ORG of I-ORG the I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Proteomics I-ORG SKLPO201703 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 31600632 B-AWARD and O the O Specific B-ORG Research I-ORG Fund I-ORG for I-ORG TCM I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Guangdong I-ORG Provincial I-ORG Hospital I-ORG of I-ORG Chinese I-ORG Medicine I-ORG YN2019QL18 O O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 82271483 B-AWARD the O Shandong B-ORG Province I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O ZR2020MH150 B-AWARD and O ZR2020MH149 B-AWARD the O Support B-ORG Program I-ORG for I-ORG Youth I-ORG Innovation I-ORG Technology I-ORG in I-ORG Colleges I-ORG and I-ORG Universities I-ORG of I-ORG Shandong I-ORG Province I-ORG of I-ORG China I-ORG Grant O No. O 2019KJK004 B-AWARD and O the O Student B-ORG Innovation I-ORG Fund I-ORG of I-ORG Weifang I-ORG Medical I-ORG University I-ORG Grant O No. O KX2022395 B-AWARD The O authors O are O grateful O for O the O financial O support O for O this O study O from O the O Fundamental O Research O Funds O for O the B-ORG Central I-ORG Universities I-ORG Grant O No. O HIT.NSRIF.201602 B-AWARD HIT.NSRIF.201704 I-AWARD HIT I-AWARD MKSTISP.201617 O the B-ORG Shandong I-ORG Provincial I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG Grant O No. O 2016ZDJS05A07 B-AWARD 2017CXGC0922 I-AWARD 2018GGX103003 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG Grant O No. O ZR2017QEE005 B-AWARD ZR2017PEE010 O This O work O was O supported O by O National B-ORG Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases I-ORG grant O numbers O R01AI110769-01 B-AWARD WKW O R21AI135292-01A1 B-AWARD WKW O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG grant O number O P30GM114737 B-AWARD Ministry B-ORG of I-ORG Health I-ORG and I-ORG Welfare I-ORG grant O number O MOHW109-TDU-B-212-114006 B-AWARD JJT O and O National B-ORG Health I-ORG Research I-ORG Institute I-ORG Taiwan I-ORG grant O number O NHRI-109A1-MRCO-03202009 B-AWARD JJT O This O work O was O supported O by O grants O from O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG No. O XDB11040100 B-AWARD to O RF, O by O the O Major B-ORG State I-ORG Basic I-ORG Research I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 973 I-ORG Program I-ORG No. O 2014CB138401 B-AWARD to O XC, O and O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31672000 B-AWARD to O LZ. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O authors O wish O to O acknowledge O funding O from O the O European B-ORG Research I-ORG Council I-ORG "Mechanobio O Grant O No. O 258321,https://erc.europa.eu B-AWARD DL O the O Engineering B-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG "Multisim O Grant O No. O EP/K03877X/1,https://epsrc.ukri.org B-AWARD DL O the O Great B-ORG Britain I-ORG Sasakawa I-ORG Foundation I-ORG Grant O No. O 4879,http://www.gbsf.org.uk B-AWARD SM) O and O the O University B-ORG of I-ORG Sheffield I-ORG "Mechanoreceptors O in O health O and O disease O Network O Scholarship O Grant O No. O 149716529,https://www.sheffield.ac.uk B-AWARD SM O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the B-ORG basic I-ORG scientific I-ORG research I-ORG project I-ORG of I-ORG Wenzhou I-ORG Y20180115 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. O LQ18H090009 O as O well O as O medical B-ORG and I-ORG health I-ORG research I-ORG project I-ORG of I-ORG Zhejiang I-ORG province I-ORG 2020KY926 O The O funding O body O played O no O role O in O the O study O design O the O collection O analysis O and O interpretation O of O the O data O This O study O is O supported O by O the O Guangdong B-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG CN) O No. O 2016A020215139 B-AWARD The O authors O also O acknowledge O the O support O of O the O other O two O funds O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81774451 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017A030313827 O The O funders O had O no O role O in O the O design O of O the O study O analysis O collection O and O interpretation O of O the O data O or O the O writing O and O decision O for O publication O of O the O manuscript O The O funder O does O not O have O ultimate O authority O over O any O of O these O activities O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O NSFC81770925 B-AWARD NSFC81790641 B-AWARD Xuhui B-ORG District I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG Key I-ORG Disease I-ORG Joint I-ORG Project I-ORG XHLHGG201807 O the O Non-profit B-ORG Central I-ORG Research I-ORG Institute I-ORG Fund I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG 2018PT32019 O Outstanding B-ORG Academic I-ORG Leaders I-ORG in I-ORG Shanghai I-ORG 20XD1401100 O Program B-ORG for I-ORG Outstanding I-ORG Medical I-ORG Academic I-ORG Leader I-ORG 2019LJ01 O and O Aging B-ORG and I-ORG women’s I-ORG and I-ORG children’s I-ORG health I-ORG Special I-ORG project I-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Health I-ORG Commission I-ORG 2020YJZX0102 O The O funding O body O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O R.C.O.C O received O funding O support O from O MQ B-ORG Research I-ORG MQ1PI100009 O and O US B-ORG Department I-ORG of I-ORG Defense I-ORG W81XWH-12-1-0007 O O.J.K O is O supported O by O a O fellowship O from O an O FWO B-ORG Odysseus I-ORG grant I-ORG Myin-Germeys O FWO I-AWARD GOF8416N O This O work O is O supported O by O a O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O grant O 31470251 O to O XZ O a O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG “973” O Program O O 2007CB707801 B-AWARD to O XZ O a O grant O from O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG # O 2015NT10 B-AWARD to O XH O and O an O Open B-ORG Fund I-ORG of I-ORG Key I-ORG Laboratory I-ORG of I-ORG Cell I-ORG Proliferation I-ORG and I-ORG Regulation I-ORG Biology I-ORG Ministry I-ORG of I-ORG Education I-ORG # O 201502 B-AWARD to O XH O The O authors O express O their O sincere O gratitude O for O substantial O funding O about O this O study O received O from O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG grant O no. O 2662018QD042 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 31772785 B-AWARD and O Da B-ORG Bei I-ORG Nong I-ORG Group I-ORG Promoted I-ORG Project I-ORG for I-ORG Young I-ORG Scholar I-ORG of I-ORG HZAU I-ORG grant O no. O 2017DBN009 B-AWARD The O authors O are O greatly O thankful O for O the O help O and O support O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. I-AWARD 51505375 O Open B-ORG Project I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Mechanical I-ORG Transmission I-ORG Grant O No. I-AWARD SKLMT-KFKT-201510 O Scientific B-ORG Research I-ORG Program I-ORG of I-ORG Shanxi I-ORG Provincial I-ORG Education I-ORG Department I-ORG of I-ORG China I-ORG 15JS068 O 15JK1549 O This O study O was O supported O by O European B-ORG Research I-ORG Council I-ORG advanced O grant O GAP O 670428—BRAIN2MIND_NEUROCOMP O Medical B-ORG Research I-ORG Council I-ORG programme O grants O MR/J004146/1 O and O MR/R023883/1 B-AWARD Medical O Research O Council O intramural O funding O MC_UU_00005/18 O to O M.A.L.R O Medical O Research O Council O Career O Development O Award O MR/V031481/1 O to O A.D.H O and O the O Rosetrees B-ORG Trust I-ORG A1699 O to O A.D.H O and O M.A.L.R O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O 61772175 B-AWARD 61801170 I-AWARD 61501405 I-AWARD U1504619 O National O Thirteen O Five O Equipment O Research O Fund O under O Grant O 6140311030207 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG under O Grant O 2018YFB0904905 B-AWARD Science O and O Technology O Major O Program O of O Henan O Province O of O China O under O Grant O 161100210900 O Program O for O Science O and O Technology O Innovation O Talents O in O the O University O of O Henan O Province(17HASTIT025 O Science O and O Technology O Research O Project O of O Henan O Province O under O Grant O 182102210285 O Postdoctoral B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O 2018M632772 B-AWARD 2018M633351 I-AWARD This O work O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61772381 O 61572368 O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2042017kf0219 O 2042018kf0249 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2018YFC0407904 O Huazhong O Agricultural O University O Scientific O O Technological O Self-innovation O Foundation O National O Innovation O and O Entrepreneurship O Training O Program O for O College O Students O Program O No. O 201910504142 O The O funders O have O no O role O in O study O design O data O collection O data O analysis O data O interpretation O or O writing O of O the O manuscript O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O No. O 51905228 B-AWARD 51705217 O 51805214 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG grant O No. O 2018M640515 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG grant O No. O 18KJB460008 B-AWARD and O Science O and O Technology O Innovation O Project O of O Jiangsu O University O of O Science O and O Technology O for O Youth O grant O No. O 1022921801 O This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFC1303100 B-AWARD the O National B-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81472424 B-AWARD and O the O Shanghai B-ORG Medical I-ORG Center I-ORG of I-ORG Key I-ORG Programs I-ORG for I-ORG Female I-ORG Reproductive I-ORG Diseases I-ORG No. O 2017ZZ01016 B-AWARD This O research O was O supported O with O intramural O funds O from O the O Oklahoma O Tobacco O Settlement O Endowment O Trust O 092-016-0002l O the O National B-ORG Institute I-ORG on I-ORG Drug I-ORG Abuse I-ORG K99DA046563 O Stevens O PI; O K99DA046564 B-AWARD Hébert O PI; O U01DA04553 B-AWARD Wagener O PI O the O National B-ORG Cancer I-ORG Institute I-ORG R01CA20489 O Wagener O PI O the O National B-ORG Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute I-ORG K01HL148907 O Tackett O PI O and O the O Stephenson O Cancer O Center’s O Cancer O Center O Support O Grant O P30CA225520 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 91632110 B-AWARD 31700934 B-AWARD 31371106 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG of O China O Grant O No. O 2016CFB557 B-AWARD Huazhong B-ORG Agricultural I-ORG University I-ORG Scientific I-ORG I-ORG Technological I-ORG Self-innovation I-ORG Foundation I-ORG Program O No. O 2014BQ019 B-AWARD 2662018PY025 B-AWARD and O 2662017PY105 B-AWARD This O work O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51674155 B-AWARD Innovative B-ORG Team I-ORG Development I-ORG Project I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG Grant O No. O IRT_16R45 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG Grant O No. O ZR2016EEM09 B-AWARD and O Major B-ORG Research I-ORG and I-ORG Development I-ORG Projects I-ORG of I-ORG Shandong I-ORG Province I-ORG Grant O No. O 2018GGX103027 B-AWARD The O study O was O supported O by O research O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31521003 O 81071957 B-AWARD the B-ORG Key I-ORG Project I-ORG in I-ORG the I-ORG National I-ORG Science I-ORG I-ORG Technology I-ORG Pillar I-ORG Program I-ORG 2011BAI09B00 O Suzhou B-ORG City I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG SYS201419 O and O 111 B-ORG Project I-ORG B13016 O Computational O support O was O provided O by O the O High-End O Computing O Center O located O at O Fudan O University O This O study O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31300103 B-AWARD 31371373 B-AWARD 31771572 B-AWARD the B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20151395 O the B-ORG Open I-ORG Fund I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Natural I-ORG Medicines I-ORG No. O SKLNMKF201606 B-AWARD the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 021414380330 O Research B-ORG of I-ORG Institute I-ORG of I-ORG hospital I-ORG management I-ORG Nanjing I-ORG University I-ORG NDYG2017016 O the B-ORG Innovation I-ORG Capability I-ORG Development I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O BM2015004 B-AWARD the O Nanjing O Healthy O and O Family O Planning O Commission O Medical O Science O Technology O Innovation O Platform O Project O ZDX16006 O and O the O National O Human O Genetic O Resources O Sharing O Service O Platform O 2005DKA21300 O This O work O was O supported O by O projects O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0502100 O and O China B-ORG Scholarship I-ORG Council I-ORG – I-ORG The I-ORG University I-ORG of I-ORG Western I-ORG Australia I-ORG Joint I-ORG Scholarship I-ORG 201708320259 O and O the O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O P.R O China O This O study O was O partially O supported O by O grant O no. O SAF2009-14037 B-AWARD from O the O Spanish B-ORG Ministry I-ORG of I-ORG Economy I-ORG and I-ORG Competitivity I-ORG MINECO O GREIB.PT_2010_04 B-AWARD from O the O CEIBiotic B-ORG Program I-ORG of I-ORG the I-ORG University I-ORG of I-ORG Granada I-ORG Spain O and O CTS-101 B-AWARD from I-AWARD the I-AWARD Consejería I-AWARD de I-AWARD Innovación I-AWARD Ciencia I-AWARD y I-AWARD Empresa I-AWARD Junta B-ORG de I-ORG Andalucía I-ORG Spain I-ORG This O research O was O funded O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China O grant O number O 2017YFB0902703 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 51777073 B-AWARD Hebei B-ORG Province I-ORG Natural I-ORG Science I-ORG Foundation O grant O number O E2017502061 B-AWARD State O Key O Laboratory O of O Reliability O and O Intelligence O of O Electrical O Equipment O Hebei O University O of O Technology O grant O number O EERIKF2018011 O and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities O grant O number O 2019MS078 B-AWARD This O study O was O supported O by O the O CNRS O the O ENS O de O Lyon O the O UPMC O Université O Paris O 06 O the O Agence B-ORG Nationale I-ORG de I-ORG la I-ORG Recherche I-ORG grants O ANR-2010-BLAN-1234-01 B-AWARD to O V.L O and O ANR-11-JSV2-002-01 B-AWARD to O M.S O MINECO B-ORG SAF2013-48397-R O FEDER O and O Xunta B-ORG de I-ORG Galicia I-ORG Consolidación O INBIOMED-FEDER I-AWARD ‘Unha O maneira O de O facer O Galicia’ O to O A.R.dL O and O the O European B-ORG Union I-ORG FP7 O BIOCAPS I-AWARD 316265/REGPOT-2012-2013.1 O to O S.A O The O work O leading O to O these O results O has O received O funding O from O theEuropean O Union I-ORG Seventh I-ORG Framework I-ORG Programme I-ORG for I-ORG research I-ORG technology I-ORG development I-ORG and I-ORG demonstration[grant O agreement O no. O 310451 B-AWARD NanoMILE O and O theNetherlands O Food I-ORG and I-ORG Consumer I-ORG Product I-ORG Safety I-ORG Authority I-ORG NVWA)[V090016 O MRM O is O supported O by O the10.13039/501100000274British O Heart I-ORG Foundation[SP/15/8/31575 O CH/09/002 B-AWARD The O project O was O funded O by O the O Croatian B-ORG Ministry I-ORG of I-ORG Science O grant O number O 258-2160800-0333 B-AWARD to O Š.A O J.T O was O supported O by O the O Croatian B-ORG Science I-ORG Foundation I-ORG grant O No: O IP-2014-09-1904 B-AWARD and O the O Croatian B-ORG Ministry I-ORG of I-ORG Science I-ORG Sport I-ORG and I-ORG Education I-ORG grant O number O 216-000000-3348 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M632052,http://chinapostdoctor.org.cn O Shanghai B-ORG Pujiang I-ORG Program I-ORG 18PJC034,http://www.stcsm.gov.cn O and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2018ECNU-HWFW011,http://www.ecnu.edu.cn O to O HW. O This O work O was O supported O by O the B-ORG Provincial I-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG No. O 2015JJ3139 O the B-ORG Science I-ORG and I-ORG Technology I-ORG Office I-ORG of I-ORG Changsha I-ORG City I-ORG K1203040-31 O the B-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG Hunan I-ORG Province I-ORG B2014-12 O B2016105 B-AWARD the B-ORG Administration I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG of I-ORG Hunan I-ORG Province I-ORG No.2015116 O the B-ORG Hunan I-ORG Provincial I-ORG Innovation I-ORG Foundation I-ORG for I-ORG Postgraduate I-ORG CX2016B060 O and O the B-ORG China I-ORG Scholarship I-ORG Council I-ORG student O ID: I-AWARD 201606370164 I-AWARD and I-AWARD 201606375101 O This O study O was O funded O by O the B-ORG Earmarked I-ORG Fund I-ORG for I-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-45-15 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31872604 O 31572658 B-AWARD and O the B-ORG Major I-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG Project I-ORG of I-ORG Hubei I-ORG Province I-ORG 2015ABA045 O This O work O was O supported O by O the O Foundation B-ORG from I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2018C02003 O LGN18C170005 B-AWARD the O China B-ORG postdoctoral I-ORG foundation I-ORG 2018M632509 O and O the O Zhejiang B-ORG postdoctoral I-ORG foundation I-ORG 20170123 O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O National B-ORG Funds I-ORG from I-ORG Fundação I-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG a I-ORG Tecnologia I-ORG FCT O through O project O UID/Multi/50016/2020 B-AWARD and O Sara B-ORG Baptista-Silva I-ORG gratefully I-ORG acknowledges I-ORG FCT I-ORG for O the O grants O ref O SFRH/BPD/116024/2016 B-AWARD The O work O was O also O supported O by O TEX4WOUNDS B-ORG project O n.º O POCI-01-0247-FEDER-047029 B-AWARD Funded O under O the O Incentive B-ORG System I-ORG for I-ORG Research I-ORG and I-ORG Technological I-ORG Development I-ORG R&DT I-ORG Projects I-ORG in I-ORG Co-Promotion I-ORG Notice O 17/SI/2019 O This O research O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61761013 B-AWARD and O 61864001 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangxi I-ORG Province I-ORG No. O 2017GXNSFAA198116 B-AWARD and O the O Guangxi B-ORG Key I-ORG Laboratory I-ORG of I-ORG Automatic I-ORG Detection I-ORG Technology I-ORG and I-ORG Instruments I-ORG Foundation I-ORG Project I-ORG No. O YQ17113 B-AWARD This O research O was O supported O by O funding O from O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIAIDhttps://www.niaid.nih.gov/(R21 O AI139358-01 O Centers B-ORG for I-ORG Disease I-ORG Control I-ORG and I-ORG Preventionhttps://www.cdc.gov/(200-2017-93143 O and O USAIDhttps://www.usaid.gov/(AID-OAA-F-16-00061 B-ORG to O C.J.M O Microscopy O infrastructure O at O Johns O Hopkins O School O of O Medicine O Microscope O Core O Facility O used O in O this O research O was O supported O by O the O National O Institutes O of O Health O NCRR O S10OD016374 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81771534 O to O GL, O 81820108016 B-AWARD to O YS2 O Key B-ORG science I-ORG and I-ORG technology I-ORG foundation I-ORG of I-ORG Henan I-ORG Province I-ORG 172102310082 O to O GL O Key B-ORG research I-ORG projects I-ORG of I-ORG Henan I-ORG higher I-ORG education I-ORG institutions I-ORG 18A320057 O to O GL O Research O and O Development O Project O of O Young O Doctors O in O Reproductive O Medicine O of O Chinese O Medical O Association O to O GL O This O study O was O funded O by O grants O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No.2017YFD0501200 O the O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG 973 I-ORG program I-ORG of I-ORG China I-ORG Grant O No. O 2015CB150300 B-AWARD and O the O Professorial B-ORG and I-ORG Doctoral I-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Huizhou I-ORG University I-ORG Grant O No. O 2018JB038 B-AWARD This O work O was O supported O by O the B-ORG National I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81274033 B-AWARD the B-ORG Research I-ORG Project I-ORG of I-ORG Chinese I-ORG Ministry I-ORG of I-ORG Education I-ORG Grant O No. O 113037A B-AWARD and O the B-ORG Zhejiang I-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O LZ14H280001 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21808069 O 21878103 B-AWARD and O 21676098 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG of I-ORG China I-ORG 2018A030310368 O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Pulp I-ORG and I-ORG Paper I-ORG Engineering I-ORG 2017C03 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017M612667 O 2018T110871 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2017BQ084 O 2017PY013 B-AWARD Research B-ORG grants I-ORG DP150100956 O DP180100858 B-AWARD to O A.M.v.O O N.E.D O Australian B-ORG Research I-ORG Council O Australian O Laureate O Fellowship O FL140100027 O to O A.M.v.O O King B-ORG Abdullah I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology O Saudi O Arabia O OSR-2015-CRG4-2644 O to O N.E.D O A.M.v.O. O Nederlandse B-ORG Organisatie I-ORG voor I-ORG Wetenschappelijk I-ORG Onderzoek I-ORG 12CMCE03 O to O L.M.S O Funding O for O open O access O charge O Australian O Research O Council O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31300054 O Youth B-ORG Fund I-ORG of I-ORG the I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG of I-ORG China I-ORG BK20130228 O Grants B-ORG from I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Xuzhou I-ORG city I-ORG KC15N0014 O Postgraduate B-ORG Research I-ORG and I-ORG Innovation I-ORG Plan I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Normal I-ORG University I-ORG 2016YZD019 O and O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O This O work O was O supported O by O grants O from O the O Ministerio B-ORG de I-ORG Ciencia I-ORG e I-ORG Innovación I-ORG MINECO)/FEDER O BFU2012-38208 O Ministerio B-ORG de I-ORG Economía I-ORG Industria I-ORG y I-ORG Competitividad/FEDER O BFU2015-68655-P O and O the O Junta B-ORG de I-ORG Andalucía I-ORG P11-CVI-7290 O to O A.R.M O L.A.-G O was O supported O by O a O CONACYT O Mexico O Fellowship O for O short-term O visits O M.P.-R O was O supported O by O a O PhD O Fellowship O from O the O Plan O Propio O UPO O and O by O a O fellowship O from O the O Programa O Predoctoral O de O Formación O de O Personal O Investigador O No O Doctor O del O Departamento O de O Educación O del O Gobierno O Vasco O J.A.A O was O supported O by O a O MINECO O BFU2015-64536 O grant O Y.A.-T O was O supported O by O a O Postdoctoral O Fellowship O from O the O Junta O de O Andalucía O Spain O P.D-F O was O supported O by O a O MINECO O FPI O PhD O Fellowship O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31601886 B-AWARD and I-AWARD 31093430 O the O Program B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Talents I-ORG Team I-ORG Guizhou I-ORG Province I-ORG No. O 20144001 B-AWARD the O Program B-ORG of I-ORG Excellent I-ORG Innovation I-ORG Talents I-ORG Guizhou I-ORG Province I-ORG No. O 20154021 B-AWARD the O Provincial B-ORG Outstanding I-ORG Graduate I-ORG Program I-ORG for I-ORG Agricultural I-ORG Entomology I-ORG and I-ORG Pest I-ORG Control I-ORG ZYRC-2013 O and O the O International B-ORG cooperation I-ORG base I-ORG for I-ORG insect I-ORG evolutionary I-ORG biology I-ORG and I-ORG pest I-ORG control I-ORG No. O 20165802 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Special O fund O of O Fujian B-ORG Development I-ORG and I-ORG Reform I-ORG Commission I-ORG 31010308 O Fujian B-ORG provincial I-ORG medical I-ORG center I-ORG of I-ORG hepatobiliary I-ORG key I-ORG Clinical I-ORG Specialty I-ORG Discipline I-ORG Construction I-ORG Program I-ORG of I-ORG Fuzhou I-ORG 201912002 O and O Fujian B-ORG provincial I-ORG health I-ORG research I-ORG talent I-ORG training I-ORG project I-ORG 2019-1-85 O This O work O was O supported O by O the O Slovenian B-ORG Research I-ORG Agency I-ORG through O the O research O core O funding O no. O P4-0165 B-AWARD the O projects O no. O J4-1777 O and O J1-2467 O the O contract O no. O 1000-22-0105 O in O accordance O with O the O agreement O on O co) O financing O research O activity O in O 2022 O as O well O as O by O the O European B-ORG Union I-ORG Horizon I-ORG 2020 I-ORG Framework I-ORG Programme I-ORG under O grant O agreement O no. O 862858 B-AWARD project O ADAPT O Funding O was O also O provided O by O the O Plant-Microbe O Interfaces O PMI O Scientific O Focus O Area O in O the O Genomic O Sciences O Program O of O from O the O US B-ORG Department I-ORG of I-ORG Energy O Office O of O Science O Office O of O Biological O and O Environmental O Research O This O manuscript O has O been O coauthored O by O UT-Battelle O LLC O under O contract O no. O DE-AC05-00OR22725 B-AWARD with O the O US O Department O of O Energy O The O United O States O Government O retains O and O the O publisher O by O accepting O the O article O for O publication O acknowledges O that O the O United O States O Government O retains O a O nonexclusive O paid-up O irrevocable O world-wide O license O to O publish O or O reproduce O the O published O form O of O this O manuscript O or O allow O others O to O do O so, O for O United O States O Government O purposes O The O Department O of O Energy O will O provide O public O access O to O these O results O of O federally O sponsored O research O in O accordance O with O the O DOE O Public O Access O Plan O http://energy.gov/downloads/doe-public-access-plan O last O accessed O September O 16, O 2020 O This O study O was O funded O by O grants O from O the B-ORG municipal I-ORG science I-ORG and I-ORG technology I-ORG plan I-ORG projects I-ORG of I-ORG Zhoushan I-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau(Nos.2016C11001 O Public B-ORG welfare I-ORG project I-ORG of I-ORG Zhoushan I-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG Zhejiang I-ORG Province I-ORG Nos.2016C31038 O 2014C31069 O Youth B-ORG Fund I-ORG Project I-ORG of I-ORG Zhoushan I-ORG Municipal I-ORG Health I-ORG Planning I-ORG Bureau I-ORG Zhejiang I-ORG Province I-ORG Nos.2013Q01 O This O study O was O supported O by O funds O from O the O Chinese B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Batch O 54 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81441006 O and O 81600168 B-AWARD and O the B-ORG Basic I-ORG Research I-ORG Project I-ORG of I-ORG Shenzhen I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG No. O JCYJ20160422145031770 B-AWARD This O project O was O funded O by O Joints B-ORG Funds I-ORG for I-ORG the I-ORG Innovation I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Fujian I-ORG Province I-ORG Grant O numbers O 2018Y9107 B-AWARD 2019Y9034 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG China I-ORG Grant O numbers O 2019J01201 B-AWARD 2019J05140 B-AWARD Fujian B-ORG Provincial I-ORG Health I-ORG Technology I-ORG Project I-ORG Grant O number:s O 2018-CX-11 B-AWARD 2018-ZQN-19 B-AWARD 2019-ZQN-14 B-AWARD Startup B-ORG for I-ORG Scientific I-ORG Research I-ORG Fujian I-ORG Medical I-ORG University I-ORG Grant O number O 2018QH1222 B-AWARD and O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Fujian I-ORG Province I-ORG China I-ORG Grant O number O 2018Y2003 B-AWARD This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81760776 B-AWARD National O Natural O Science O Foundation O of O China O No. O 81874336 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Inner I-ORG Mongolia I-ORG No. O 2018ZD13 B-AWARD Agriculture B-ORG Research I-ORG System I-ORG of I-ORG China I-ORG No.CARS-21 O 2018 O Chinese O medicine O public O health O service O subsidy O special O “the O fourth O national O survey O of O Chinese O materia O medica O resources” O No. O Finance O Society O 2018 O 43 O Financial O support O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61601227 B-AWARD 31570552 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017M621598 O Nature B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20160939 O Natural O Science O Foundation O of O the O Jiangsu O Higher O Education O Institutions O of O China O 16KJB180010 O Key B-ORG University I-ORG Science I-ORG Research I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG 17KJA220004 O Research O and O Demonstration O of O Green O Integrated O Technology O of O Fast-growing O poplar O 1704a07020076 O and O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O Study O authors O were O supported O with O funding O from O a O number O of O pre-doctoral O training O grants O including O the O Initiative O to O Maximize O Student O Diversity O from O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG of O the O National O Institutes O of O Health O # O GM055353-13 B-AWARD CS O a O training O award O from O the O Maternal B-ORG and I-ORG Child I-ORG Health I-ORG Bureau I-ORG #T76MC00001 O CS) O and O the O Perinatal O and O Pediatric O Epidemiology O pre-doctoral O training O grant O from O the O National B-ORG Institute I-ORG of I-ORG Child I-ORG Health I-ORG and I-ORG Human I-ORG Development I-ORG T32HD060454 O SN O This O work O was O financially O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2018YFB0407102 B-AWARD the O Foundation O of O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O Grant O Nos O 61421002 B-AWARD 61675041 B-AWARD 51703019 B-AWARD and O 51503022 B-AWARD the O Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG Grant O Nos O 2019YFH0005 B-AWARD 2019YFG0121 B-AWARD and O 2019YJ0178 B-AWARD the O Scientific B-ORG and I-ORG Technological I-ORG Research I-ORG Program I-ORG of I-ORG Chongqing I-ORG Municipal I-ORG Education I-ORG Commission I-ORG KJ1601126 B-AWARD and O the O Chongqing B-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG No.cstc2015jcyjA50036 O No.cstc2016jcyjys50001 O and O No.cstc2016jcyj0367 O This O work O is O also O sponsored O by O the O Sichuan O Province O Key O Laboratory O of O Display O Science O and O Technology O This O work O was O supported O by O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Shenzhen I-ORG Municipality I-ORG JSGG20191129110033736 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 6217030813 O Basic B-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2021A1515010964 O and O Science B-ORG Technology I-ORG and I-ORG Innovation I-ORG Commission I-ORG of I-ORG Shenzhen I-ORG Municipality I-ORG JCYJ20200109105810074 O SGDX20190919094803949 O This O work O was O supported O by O a O Cancer B-ORG Research I-ORG UK I-ORG program I-ORG grant O C18281/A19169 O Cancer B-ORG Research I-ORG UK I-ORG Research I-ORG PhD I-ORG studentships I-ORG C18281/A20988 O to O JY O and O RJQL O and O a O Cancer B-ORG Research I-ORG UK I-ORG Population I-ORG Research I-ORG Postdoctoral I-ORG Fellowship I-ORG C52724/A20138 O to O PCH O This O work O was O also O supported O by O a O three-year O grant O to O identify O modifiable O risk O factors O for O prostate O cancer O by O the O World B-ORG Cancer I-ORG Research I-ORG Fund I-ORG International O grant O reference O number O 2015/1421 B-AWARD to O SJL O The O Medical B-ORG Research I-ORG Council I-ORG Integrative O Epidemiology O Unit O at O the O University O of O Bristol O is O supported O by O the O Medical O Research O Council O MC_UU_12013/1 O MC_UU_12013/2 B-AWARD and O MC_UU_12013/3 B-AWARD and O the O University O of O Bristol O This O work O was O supported O by O the O Major B-ORG Project I-ORG of I-ORG Agricultural I-ORG Biological I-ORG Breeding I-ORG 2022ZD0401501 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2021YFD2200201 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 32071797 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O 507 O no. O 31671731 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG grant O 508 O no. O 2016YFD0101300 B-AWARD and O Jiangsu B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O BK20151369 B-AWARD This O study O was O supported O by O the B-ORG Medical I-ORG and I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. O 2018RC079 B-AWARD to O S. O W O the B-ORG Youth I-ORG Research I-ORG Fund I-ORG of I-ORG Jinhua I-ORG Hospital I-ORG of I-ORG Zhejiang I-ORG University I-ORG No. O JY2017205 B-AWARD to O S. O W O the B-ORG Science I-ORG and I-ORG Technology I-ORG Key I-ORG Project I-ORG of I-ORG Jinhua I-ORG City I-ORG No. O 20163011 B-AWARD to O S. O W O and O the B-ORG Chinese I-ORG Medicine I-ORG Science I-ORG and I-ORG Technology I-ORG project I-ORG of I-ORG Jinhua I-ORG City I-ORG No. O 2017jzk05 B-AWARD to O S. O W). O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O Grant O No. O 81702603 B-AWARD and O the O Key B-ORG Project I-ORG of I-ORG the I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG Grant O No. O ZR2014HZ004 B-AWARD Medical B-ORG and I-ORG Health I-ORG Technology I-ORG Development I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG Grant O No. O 2015WS0309 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O IWHR B-ORG Research I-ORG I-ORG Development I-ORG Support I-ORG Program I-ORG Grant O No. O SE0145B132017 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2018YFC0507002 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG of I-ORG China I-ORG West I-ORG Normal I-ORG University I-ORG Grant O No. O 17C032 B-AWARD 16A001 B-AWARD the O Meritocracy B-ORG Research I-ORG Funds I-ORG of I-ORG China I-ORG West I-ORG Normal I-ORG University I-ORG Grant O No. O 17YC134 B-AWARD 17YC105 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 41971015 B-AWARD the B-ORG Project I-ORG of I-ORG Science I-ORG I-ORG Technology I-ORG Department I-ORG of I-ORG Sichuan I-ORG Province I-ORG Grant O No. O 2018SZ0337 B-AWARD 2017JY0189 B-AWARD and O the O Project O of O Sichuan B-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG Grant O No. O 18TD0025 B-AWARD 17AZ0385 B-AWARD All O the O external O funding O or O sources O of O support O received O during O this O study O and O there O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG J.L O Grant O Number O 81802046 B-AWARD Foundation O for O Innovative B-ORG Research I-ORG Team I-ORG of I-ORG Hubei I-ORG University I-ORG of I-ORG Medicine I-ORG J.L O Grant O Number O FDFR201603 B-AWARD and O Health B-ORG Commission I-ORG of I-ORG Hubei I-ORG Province I-ORG Scientific I-ORG Research I-ORG Project I-ORG YT.X O Grant O Number O WJ2019Q012 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O SC, O PRB O and O DAM O are O supported O by O SPARKS B-ORG Children’s I-ORG Medical I-ORG Research I-ORG Charity I-ORG P48061 O and O Imperial O NIHR O Biomedical O Research O Centre O DAM O is O supported O by O a O Career B-ORG Development I-ORG Award I-ORG from I-ORG the I-ORG Medical I-ORG Research I-ORG Council I-ORG MR/L009226/1 O LT O is O supported O by O the O EC B-ORG funded I-ORG project I-ORG PhenoMeNal I-ORG contract O 654241 B-AWARD Wellcome B-ORG Trust I-ORG PS3162_WHCP O to I-AWARD J.H O British B-ORG Heart I-ORG Foundation I-ORG FS/14/27/30752 O to O M.S.S O FS/11/46/28861 O to O R.P O FS/05/006 O to I-AWARD J.D O and O FS O 04/079 I-AWARD to I-AWARD D.F O Medical B-ORG Research I-ORG Council I-ORG MR/M018369/1 O to O C.C O and O G1000357 O to O S.S O This O work O was O supported O by O NSFC-CGIAR B-ORG International I-ORG Regional I-ORG Cooperation I-ORG and I-ORG Exchange I-ORG Programs I-ORG 31361140366 O National B-ORG Science I-ORG and I-ORG Technology I-ORG Infrastructure I-ORG Program I-ORG 2015BAD15B01 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31271776 O National B-ORG Nonprofit I-ORG Institute I-ORG Research I-ORG Grant I-ORG of I-ORG CATAS-TCGRI I-ORG 1630032014051 O and O the B-ORG Initial I-ORG Fund I-ORG of I-ORG High-level I-ORG Creative I-ORG Talents I-ORG in I-ORG Hainan I-ORG Province I-ORG 2012-Chen O Songbi O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O is O financially O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Grant O 2020YFC1909601 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O grants O 21878299 O 21868021 B-AWARD the O Odors B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 2021YY-GONG-119-49 O the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Hebei I-ORG Education I-ORG Department I-ORG QN2021090 O and O the O Science B-ORG Foundation I-ORG of I-ORG Hebei I-ORG Normal I-ORG University I-ORG L2021034 O L2021B28 B-AWARD Medical B-ORG Research I-ORG Council I-ORG Doctoral I-ORG Training I-ORG Centre I-ORG PhD O scholarship O MR/K501281/1 O Imperial B-ORG College I-ORG PhD-scholarship O EP/M506345/1),La O Caixastudentship O to O ARM O Portuguese B-ORG Foundation I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG SFRH/BD/52036/2012 O to O ALN O Grants O from O the O European B-ORG Commission I-ORG FGENTCARD O LSHG-CT-2006-037683 B-AWARD EURATRANS B-AWARD HEALTH-F4-2010-241504 B-AWARD METACARDIS B-AWARD HEALTH-F4-2012-305312 B-AWARD to O DG, O JKN O and O MED O The O study O was O supported O by O the B-ORG National I-ORG 863 I-ORG project I-ORG of I-ORG China I-ORG No. O 2013AA102501 O the B-ORG National I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 I-ORG Program I-ORG No.2009CB941604 O the B-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG No.CARS-42 O and O the B-ORG Program I-ORG for I-ORG Innovation I-ORG Research I-ORG Team I-ORG at I-ORG the I-ORG University I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG No. O 2010td02 O The O funders O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81401502 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG No. O H2018020 B-AWARD and O the O Post-Doctoral B-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG No. O LBH-Q17120 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O in O part O by O grants O from O Hainan B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O 319QN268 B-AWARD National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China O 2017YFD0202100 B-AWARD Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG for I-ORG Chinese I-ORG Academy I-ORG of I-ORG Tropical I-ORG Agricultural I-ORG Sciences O 1630042019006 B-AWARD The O funding O bodies O had O no O roles O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O study O was O supported O by O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG of I-ORG Yantai I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG 2016WS033 O Key B-ORG Research I-ORG and I-ORG Development I-ORG Projects I-ORG of I-ORG Shandong I-ORG 2016GSF201112 O and O Technology B-ORG Development I-ORG Plan I-ORG of I-ORG Shandong I-ORG Medical I-ORG Health I-ORG Bureau I-ORG 2016WS0696 O The O writing O of O the O article O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China(81471843 O Jiangsu B-ORG Province’s I-ORG Medical I-ORG Key I-ORG Discipline I-ORG laboratory)(ZDXKA2016025 O and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Postgraduate I-ORG Research I-ORG I-ORG Practice I-ORG Innovation I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province(KYCX17_0170 O DJB O gratefully O acknowledges O funding O from O the O Deutsche B-ORG Forschungsgemeinschaft I-ORG DFG O grant O Ba B-AWARD 3966/1-1 O and O the O National B-ORG Science I-ORG Foundation I-ORG NSF O grant O 1457369 B-AWARD SK O acknowledges O financial O support O from O the O German B-ORG Academy I-ORG of I-ORG Sciences I-ORG Leopoldina I-ORG grant O LPDS B-AWARD 2009-29 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the B-ORG National I-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2015AA020202 O Tianjin B-ORG Research I-ORG Program I-ORG of I-ORG Application I-ORG Foundation I-ORG and I-ORG Advanced I-ORG Technology I-ORG 15JCYBJC24200 O and O Novo B-ORG Nordisk-Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG NN-CAS I-ORG Research I-ORG Fund I-ORG NNCAS-2015-2 O Research O support O was O provided O by O DFG B-ORG RA1012/9-1 B-AWARD OWMR O Foncyt B-ORG PICT I-ORG 0808 B-AWARD 1288 B-AWARD DP O PICT O 1815 B-AWARD LC O Project B-ORG CyT I-ORG N°31416 O UNSL O LC O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81670680 O 81700655 B-AWARD Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province O China O 2014B020212006 O 2015B020226002 B-AWARD Key B-ORG Scientific I-ORG and I-ORG Technological I-ORG Program I-ORG of I-ORG Guangzhou I-ORG City I-ORG 201803040011 O and O the O Guangdong B-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG on I-ORG Organ I-ORG Donation I-ORG and I-ORG Transplant I-ORG Immunology I-ORG 2013A061401007 O 2017B030314018 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O has O been O supported O by O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81701683 O Health B-ORG Commission I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2020KY131 O and O Zhejiang B-ORG Provincial I-ORG Key I-ORG Discipline I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG 2017-XK-A32 O This O work O was O supported O by O Jiangsu B-ORG Province’s I-ORG Key I-ORG Discipline I-ORG I-ORG Laboratory I-ORG of I-ORG Medicine I-ORG XK201118 O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFA0103700 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC-81770258 O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Suzhou I-ORG SYS201705 O National B-ORG Clinical I-ORG Key I-ORG Specialty I-ORG of I-ORG Cardiovascular I-ORG Surgery I-ORG Jiangsu I-ORG Clinical I-ORG Research I-ORG Center I-ORG for I-ORG Cardiovascular I-ORG Surgery I-ORG BL201451 O National O Natural O Science O Foundation O of O China O No. O 31500944 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20150687 O and O BK20160321 B-AWARD and O Taishan B-ORG Scholar I-ORG Project I-ORG of I-ORG Shandong I-ORG Province I-ORG of I-ORG China I-ORG tsqn20161066 O to O Wencheng O Zhang O The O authors O are O grateful O to O the O financial O support O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos I-AWARD 61804029 I-AWARD 11504050 O Guangdong B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant B-AWARD No. I-AWARD 2018A030310353 O Scientific B-ORG Research I-ORG Starting I-ORG Foundation I-ORG of I-ORG Foshan I-ORG University I-ORG Grang B-AWARD No. I-AWARD Gg040926 O Foshan O Science O and O technology O innovation O special O funds O Grant B-AWARD No. I-AWARD 2017EZ100111 I-AWARD This O work O was O supported O by O grants O of O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O U21A20260 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Henan I-ORG Province I-ORG no. O 232300421009 B-AWARD the O Independent B-ORG Innovation I-ORG Project I-ORG of I-ORG Henan I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG no. O 2022ZC65 B-AWARD and O the O BBSRC B-ORG Newton I-ORG Fund I-ORG Joint I-ORG Centre I-ORG Awards I-ORG on I-ORG “UK-China I-ORG Centre I-ORG of I-ORG Excellence I-ORG for I-ORG Research I-ORG on I-ORG Avian I-ORG Diseases” I-ORG BBS/OS/NW/000007 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81470772 O and O U22A20314 B-AWARD the O National B-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2022YFC2504200 O and O the O Chongqing B-ORG Talent I-ORG Program I-ORG Innovative I-ORG leading I-ORG talents I-ORG CQYC20210303384 O This O study O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFA0104702 O 2016YFC1101601 B-AWARD the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 O Program I-AWARD 2014CB542201 O the O PLA B-ORG Youth I-ORG Training I-ORG Project I-ORG for I-ORG Medical I-ORG Science I-ORG 16QNP144 O and O the O Beijing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG Z161100005016059 O This O work O was O supported O by O grant O of O Polish B-ORG National I-ORG Scientific I-ORG Center I-ORG NCN I-ORG Opus B-AWARD UMO-2016/21/B/NZ1/00280 O grants O of O National B-ORG Academy I-ORG of I-ORG Sciences I-ORG of I-ORG Ukraine I-ORG Grants O 5-17 O 6-17 B-AWARD and O 35-18 B-AWARD and O grant O of O Science B-ORG and I-ORG Technology I-ORG Center I-ORG in I-ORG Ukraine I-ORG STCU I-ORG Grant O 6188 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31801525 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2018A030313874 O Guangdong O Academy O of O Agricultural O Sciences O Dean’s O Fund O 201905 O Open B-ORG Project I-ORG Program I-ORG of I-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Green I-ORG Processing I-ORG Technology I-ORG and I-ORG Product I-ORG Safety I-ORG of I-ORG Natural I-ORG Products I-ORG KL-2018-02 O Guangdong O Modern O Agricultural O Industry O Technology O System O Innovation O Team O 2018LM1087 O 2018LM2154 O The O project O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21875154 O 21473120 B-AWARD the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2015AA034601 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG of I-ORG China I-ORG BK20190829 O This O research O was O supported O by O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG No. O XDB26000000 B-AWARD XDB310301 B-AWARD for O collecting O materials O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31570223 B-AWARD 41790454 B-AWARD 31770231 B-AWARD and O 31470315 B-AWARD for O doing O experiments O and O analyzing O data O the O Basic B-ORG Project I-ORG of I-ORG the I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Palaeobiology I-ORG and I-ORG Stratigraphy I-ORG 20192101 O and O the O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG President’s I-ORG International I-ORG Fellowship I-ORG Initiative I-ORG No. O 2018VBA0016 B-AWARD for O writing O and O revising O the O manuscript O This O work O was O supported O by O Charity B-ORG Project I-ORG of I-ORG National I-ORG Ministry I-ORG of I-ORG Health I-ORG grant O number I-AWARD 201202014 O 973 B-ORG Project I-ORG of I-ORG National I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Grant I-ORG grant O number I-AWARD 2012CB910803 O 863 B-ORG Key I-ORG Projects I-ORG of I-ORG National I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Grant I-ORG grant O numbers I-AWARD 2012AA02A209 I-AWARD 2012AA022502 O and O Beijing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG grant O number I-AWARD Z141100002114046 O to O Y. O Ke. O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number I-AWARD 81473033 O to O Z. O He. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFA0104604 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31570834 I-AWARD 91539105 I-AWARD 91313303 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2016CM01 O This O research O was O supported O byExelixis O Inc.(R/136892),Breast O Cancer I-ORG Campaign I-ORG UK)(2010NovPhD17 O andCR-UK O Imaging I-ORG Centregrant O C1060/A10334 O This O work O was O financially O supported O by O the O Central B-ORG Public-Interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund O CAFYBB2019QD001 O the O National B-ORG “12th I-ORG Five-Year” I-ORG Plan I-ORG for I-ORG Science I-ORG I-ORG Technology I-ORG Support I-ORG of I-ORG China I-ORG 2015BAD07B0106 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31800571 O 31870594 B-AWARD 31760213 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG of I-ORG China I-ORG 2016YFC050080506 O and O Key B-ORG Research I-ORG Development I-ORG Program I-ORG of I-ORG Liaoning I-ORG Province I-ORG 2017204001 O The O study O was O supported O by O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG Zhejiang I-ORG Provincial I-ORG Universities I-ORG and I-ORG Research I-ORG Institutes I-ORG No. O 2019J00048 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O No. O 41806156 B-AWARD Open B-ORG Foundation I-ORG from I-ORG Key I-ORG Laboratory I-ORG of I-ORG Tropical I-ORG Marine I-ORG Bio-resources I-ORG and I-ORG Ecology I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG LMB20201005 O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Zhoushan I-ORG 2017C32071 O O 2020C21015 B-AWARD O 2020C21016 B-AWARD Starting B-ORG Research I-ORG Fund I-ORG from I-ORG the I-ORG Zhejiang I-ORG Ocean I-ORG University I-ORG 11105090618 O O 11034150320012 B-AWARD Funding O was O provided O by O “Twelfth B-ORG Five-Year” I-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG of I-ORG China O 2011BAD08B02-3 B-AWARD Major B-ORG Project I-ORG for I-ORG the I-ORG Heilongjiang I-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Program O GZ13B004 B-AWARD Project B-ORG for I-ORG the I-ORG Heilongjiang I-ORG Province I-ORG People’s I-ORG Government O WB13B104 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Fund O 3150020596 B-AWARD and I-AWARD 31500323 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG Grant O No. O 2019JJ50968 B-AWARD 2019JJ50358 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81802947 B-AWARD Changsha B-ORG Science I-ORG and I-ORG Technology I-ORG Board I-ORG kq1801110 O This O study O was O supported O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Grant O Number O 2018YFC1602500 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Number O 31772751 B-AWARD the O Opening B-ORG Fund I-ORG of I-ORG Key I-ORG Laboratory I-ORG of I-ORG Microorganism I-ORG Technology I-ORG and I-ORG Bioinformatics I-ORG Research I-ORG of I-ORG Zhejiang I-ORG Province I-ORG Grant O Number O 2017E10010 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grant O Number O BK20190886 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O Number O 2019M661953 B-AWARD and O A B-ORG Project I-ORG Funded I-ORG by I-ORG the I-ORG Priority I-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O The O research O leading O to O these O results O has O received O funding O from O the O Austrian B-ORG Science I-ORG Fund I-ORG FWF O P O 25608-N15 O KMK O and O RDB O received O funding O from O the O US B-ORG National I-ORG Library I-ORG of I-ORG Medicine I-ORG 1R01LM011838-01 O and O the O US B-ORG National I-ORG Institute I-ORG on I-ORG Aging I-ORG K01AG044433 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O the O Guangxi B-ORG scientific I-ORG projects I-ORG Nos O AD17129063 B-AWARD and I-AWARD AA17204074 O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 91428203 B-AWARD and O the O BaGui B-ORG Fellowship I-ORG of I-ORG Guangxi I-ORG Province I-ORG No. O 2014BGXZGX03 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Project B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Assistance I-ORG in I-ORG Developing I-ORG Countries I-ORG KY201501006 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81470354 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Tianjin I-ORG 17JCQNJC13500 O and O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Medicinal I-ORG Chemical I-ORG Biology I-ORG 2018004 O This O study O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG of I-ORG China I-ORG 2016YFD0600101 O the O 2017 O Graduate B-ORG Research I-ORG and I-ORG Innovation I-ORG Program I-ORG Projects I-ORG in I-ORG Jiangsu I-ORG Province I-ORG KYCY17_0827 O and O the O PAPD O Priority O Academic O Program O Development O program O at O Nanjing B-ORG Forestry I-ORG University I-ORG Jiangsu I-ORG Provincial I-ORG Department I-ORG of I-ORG Housing I-ORG and I-ORG Urban-Rural I-ORG Development I-ORG 2016ZD44 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Non-Profit I-ORG Research I-ORG Institution I-ORG of I-ORG CAF I-ORG CAFYBB2017SZ001 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31570662 O 31500533 B-AWARD and O 61401214 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31401093 O the B-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG Department I-ORG of I-ORG Education I-ORG 12541018 O the B-ORG “Academic I-ORG Backbone” I-ORG Project I-ORG of I-ORG Northeast I-ORG Agricultural I-ORG University I-ORG 16XG17 O and O the B-ORG Open I-ORG Research I-ORG Fund I-ORG for I-ORG Key I-ORG Laboratory I-ORG of I-ORG Dairy I-ORG Science I-ORG Northeast I-ORG Agricultural I-ORG University O Ministry O of O Education O Heilongjiang O Province,China O 2015KLDSDF-02 O This O work O was O supported O by O the O Technology O development O Program O S2831187 O funded O by O the O Ministry B-ORG of I-ORG SMEs I-ORG and I-ORG Startups I-ORG in O 2019 O MSS O Korea O and O by O the O Basic O Science O Research O Program O through O the O National O Research O Foundation O of O Korea O NRF O funded O by O the O Ministry B-ORG of I-ORG Education I-ORG No.2018R1A6A1A03026005 O This O work O was O also O supported O by O the O Korea B-ORG Research I-ORG Institute I-ORG of I-ORG Chemical I-ORG Technology I-ORG KRICT O core O project O SS2021-20 O and O the O Center O for O Advanced O Soft-Electronics O funded O by O the O Ministry O of O Science O and O ICT O MSIT O of O South O Korea O as O Global O Frontier O Project O CASE-2015M3A6A5065315 O P.-F.S O received O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81670744 O 81870564 O Science B-ORG Technology I-ORG Department I-ORG of I-ORG Zhejiang I-ORG Province I-ORG of I-ORG China I-ORG No.2017C33037 O and O YF.X O received O Grants O from O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2019M652107 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81571577 B-AWARD Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O LY16H100002 B-AWARD and O Zhejiang B-ORG Provincial I-ORG Public I-ORG Technology I-ORG Applied I-ORG Research I-ORG Project I-ORG No. O 2015C33177 B-AWARD This O research O was O supported O by O the O AMED-MPS B-ORG project O issue O no. O JP17be0304205 B-AWARD JP22be1004204 B-AWARD and O the O Center B-ORG of I-ORG Innovation I-ORG COI I-ORG program I-ORG JPMJCE1307 O supported O by O the O Ministry O of O Education O Culture O Sports O Science O and O Technology O Japan O Science O and O Technology O Agency O Microfluidic O devices O were O fabricated O at O the O Kyoto O University O Nanotechnology O Hub O site O which O was O also O supported O by O the O Ministry B-ORG of I-ORG Education I-ORG Culture I-ORG Sports I-ORG Science I-ORG and I-ORG Technology I-ORG Nanotechnology I-ORG Platform I-ORG project I-ORG issue O number O JPMXP09F19KT0107 B-AWARD Wellcome B-ORG Trust I-ORG 105602/Z/14/Z O to O D.S.P O UK O Medical B-ORG Research I-ORG Council I-ORG MR/L003120/1 O British B-ORG Heart I-ORG Foundation I-ORG RG/13/13/30194 O UK O National O Institute O for O Health O Research O Cambridge O Biomedical O Research O Centre O Funding O for O open O access O charge O UK O Medical O Research O Council O MR/L003120/1 O British O Heart O Foundation O RG/13/13/30194 O This O research O was O supported O by O the O Consortium O for O Advanced O Research O Training O in O Africa O CARTA O CARTA O is O jointly O led O by O the O African O Population O and O Health O Research O Center O and O the O University O of O the O Witwatersrand O and O funded O by O the O Carnegie B-ORG Corporation I-ORG of I-ORG New I-ORG York I-ORG Grant O No--B O 8606.R02 O Sida B-ORG Grant O No:54100113 O the O DELTAS B-ORG Africa I-ORG Initiative I-ORG Grant O No: O 107768/Z/15/Z B-AWARD and O Deutscher O Akademischer O Austauschdienst O DAAD O The O DELTAS O Africa O Initiative O is O an O independent O funding O scheme O of O the O African O Academy O of O Sciences O AAS)‘s O Alliance O for O Accelerating O Excellence O in O Science O in O Africa O AESA O and O supported O by O the O New O Partnership O for O Africa’s O Development O Planning O and O Coordinating O Agency O NEPAD O Agency O with O funding O from O the O Wellcome O Trust O UK) O and O the O UK O government O The O statements O made O and O views O expressed O are O solely O the O responsibility O of O the O Fellow O The O funding O body/bodies O played O no O role O in O the O design O of O the O study O and O data O collection O process O analysis O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O Centers B-ORG for I-ORG Disease I-ORG Control I-ORG and I-ORG Prevention I-ORG grant O number O U01CK000512 B-AWARD National B-ORG Institutes I-ORG of I-ORG Health I-ORG grant O number O AI127744 B-AWARD AI136126 O u19AI142759 O University B-ORG of I-ORG Texas I-ORG Medical I-ORG Branch I-ORG grant O number O UL1TR-001439 B-AWARD the O John O S. O Dunn O Foundation O the O Amon O G. O Carter O Foundation O the O Summerfield O Robert O Foundation O and O the O Robert O J. O Kleberg O Jr. O and O Helen O C. O Kleberg O Foundation O This O research O was O funded O by O the B-ORG Icelandic I-ORG Research I-ORG fund I-ORG IRF O RANNÍS O 174425-051 O T.Š.-T O was O supported O by O The B-ORG Danish I-ORG National I-ORG Research I-ORG Foundation I-ORG DNRF106 O to O the O Stellar O Astrophysics O Centre O Aarhus O University O the B-ORG AUFF I-ORG Nova I-ORG programme I-ORG AUFF-E-2015-FLS-9-10 O the B-ORG Novo I-ORG Nordisk I-ORG Foundation I-ORG NNF19OC0056963 O and O the B-ORG Villum I-ORG Fonden I-ORG 23175 O and O 37435 B-AWARD The B-ORG Europlanet I-ORG 2020 I-ORG Research I-ORG Infrastructure I-ORG TA I-ORG program I-ORG 18-EPN4-059 O funded O T.Š.-T O participation O in O the O sampling O campaign O This O research O was O supported O by O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG XDA01010302 O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2015CB964502 O and O 2011CB966200 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31371419 O Ministry B-ORG of I-ORG Health I-ORG 2012BAI10B03 O and O Shanghai B-ORG Municipal I-ORG Commission I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG 13401900600 O This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 30871553 O the O Key B-ORG program I-ORG of I-ORG Technological I-ORG Innovation I-ORG in I-ORG Hubei I-ORG Province I-ORG No. O 2016ABA084 O the O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG Group O No. I-AWARD 118 O the O Hubei B-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Center I-ORG 201620000001048 O This O work O was O supported O by O grants O from O The B-ORG talents I-ORG program I-ORG of I-ORG Jiangsu I-ORG Cancer I-ORG Hospital I-ORG YC201805 O The B-ORG program I-ORG of I-ORG Health I-ORG Department I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BJ16028 O and O The B-ORG program I-ORG of I-ORG Jiangsu I-ORG Cancer I-ORG Hospital I-ORG ZN201607 O The O Qing B-ORG Lan I-ORG Project I-ORG 2014 O Philosophy B-ORG and I-ORG Social I-ORG Science I-ORG Research I-ORG Fund I-ORG of I-ORG Jiangsu I-ORG College I-ORG 2014SJB164 O Top-notch B-ORG Academic I-ORG Programs I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PPZY2015A067 O and O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O supported O this O study O The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O in O the O preparation O of O the O manuscript O This O research O was O funded O by O the O ANID B-ORG doctoral O project O 21211180 B-AWARD Dirección B-ORG de I-ORG Investigación-Universidad I-ORG de I-ORG La I-ORG Frontera I-ORG DI22-1001 B-AWARD DIUFRO B-ORG GAP I-ORG DI22-3038 B-AWARD ANID/FONDAP/15130015 B-ORG ANID B-ORG FONDECYT I-ORG Postdoctoral I-ORG 3190922 B-AWARD and O ANID B-ORG FONDECYT I-ORG Regular I-ORG 1191089 B-AWARD This O research O was O supported O in O part O by O The B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81871938 B-AWARD 81560393 B-AWARD 81871172 B-AWARD 81760542 B-AWARD Guangxi B-ORG Science I-ORG Fund I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG Program I-ORG 2016GXNSFFA380003 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangxi I-ORG 2016GXNSFBA380043 O This O work O was O supported O by O grants O from O Taipei B-ORG Veterans I-ORG General I-ORG Hospital I-ORG V104C-015 B-AWARD V105C-018 O Ministry O of O health O and O welfare O Center O of I-ORG Excellence I-ORG for I-ORG Cancer I-ORG Research I-ORG at I-ORG Taipei I-ORG Veterans I-ORG General I-ORG Hospital I-ORG phase I-ORG II) O MOHW103-TD-B-111-02 O MOHW104-TDU-B-211-124-001 O and O Cheng-Hsin B-ORG Yang-Ming I-ORG project I-ORG CY10411 B-AWARD This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81972172 O the O Shanghai B-ORG Municipal I-ORG Health I-ORG Commission I-ORG Grant O No. B-AWARD 2017BR026 O the O Shanghai B-ORG Education I-ORG Development I-ORG Foundation I-ORG Grant O No. B-AWARD 17SG23 O the O Shanghai B-ORG Hospital I-ORG Development I-ORG Center I-ORG Grant O No. B-AWARD SHDC12017X03 O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 22005145 B-AWARD No. O 22105103 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20210353 O BK20200471 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 30920041106 B-AWARD This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51171118 O 51772193 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2020M680977 O the O Key B-ORG R I-ORG I-ORG D I-ORG Projects I-ORG of I-ORG Liaoning I-ORG Province I-ORG 2020JH210100011 O This O research O project O was O supported O by O the O Basic B-ORG Research I-ORG Project I-ORG Dengfeng I-ORG hospital I-ORG jointly I-ORG Funded I-ORG by I-ORG Guangzhou I-ORG City I-ORG and I-ORG the I-ORG School I-ORG No.202201020586 O Independent B-ORG Project I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Respiratory I-ORG Diseases I-ORG SKLRD-Z-202005 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG No. O 2019A1515010981 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0501308 O Jiangsu B-ORG Province I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG BE2017314 O National B-ORG Mega-project I-ORG for I-ORG Innovative I-ORG Drugs I-ORG 2019ZX09721001 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81700094 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG Grant O No. O 2018J01627 B-AWARD Foundation O of O Fujian O Educational O Committee O ID: O JA0219 O Scientific O Research O Foundation O for O the O Fujian O University O of O Technology O ID: O GY-Z17016 O Australian B-ORG Research I-ORG Council I-ORG ID: O DP160101953 B-AWARD and O DE180101138 B-AWARD This O work O was O funded O by O grants O from O the O CONICET B-ORG Latin O American O grand O program O No. O 41488 B-AWARD to O MQS O Leverhulme B-ORG Trust I-ORG F/07 O 134/DF I-AWARD to O ARL O and O BBSRC B-ORG BB/I021213/1 O to O ARL O Project O support O was O provided O by O the B-ORG National I-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG 973 I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2015CB150300 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 31230073 B-AWARD and O 31472184 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Gansu I-ORG Province I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG Grant O No. O 1506RJDA133 B-AWARD This O research O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81600775 O and O 21504082 B-AWARD National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFE0117100 O Medical B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Henan I-ORG Province I-ORG 2018020398 O and O SB201902026 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81370138 B-AWARD the O Health B-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG Shandong I-ORG Province I-ORG No.2017WS026 O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG of I-ORG Shandong I-ORG Province I-ORG No.2019GSF107042 O and O No.2019GSF107051 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31802159 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Henan I-ORG Province I-ORG 182300410030 O and O the O Programs B-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG of I-ORG Henan I-ORG Province I-ORG 182102110208 O The O funding O body O had O no O role O in O the O design O of O the O study O collection O analysis O and O interpretation O of O data O or O in O the O writing O of O this O manuscript O This O research O was O funded O by O the O Brazilian B-ORG National I-ORG Council I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Development I-ORG CNPq O grant O number O 304262/2021-8 B-AWARD and O in O part O by O the O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG CAPES O Finance B-AWARD code I-AWARD 001 O and O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo—Brasil I-ORG FAPESP O grant O numbers O 2019/21603-1 B-AWARD and O 2022/03952-1 B-AWARD 1) O Forest B-ORG Park I-ORG Engineering I-ORG Technology I-ORG Research I-ORG Center I-ORG of I-ORG the I-ORG State I-ORG Forestry I-ORG Administration I-ORG PTJH15002 O 2) O Wuyishan B-ORG National I-ORG Park I-ORG Research I-ORG Institute I-ORG Special I-ORG Project I-ORG KJg20009A O 3) O National B-ORG Non-Profit I-ORG Research I-ORG Institutions I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Forestry I-ORG CAFYBB2020ZB008 O This O work O was O financially O supported O by O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grants O 81970022 B-AWARD Dr. O Aihua O Bao O 81873402 B-AWARD Prof O Min O Zhang O and O 81570018 B-AWARD Prof O Suqin O Ben O and O Shanghai B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG grant I-ORG 201440296 B-AWARD Dr. O Aihua O Bao O and O Shanghai B-ORG Jiao I-ORG Tong I-ORG University I-ORG School I-ORG of I-ORG Medicine I-ORG grant I-ORG 13XJI0063 B-AWARD Dr. O Aihua O Bao O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O 81401172 B-AWARD and O 81771532 B-AWARD Special B-ORG Fund I-ORG for I-ORG Clinical I-ORG Medicine I-ORG Scientific I-ORG Research I-ORG of I-ORG Chinese I-ORG Medical I-ORG Association I-ORG Grant O 16020180634 B-AWARD Shanghai B-ORG municipal I-ORG medical I-ORG and I-ORG health I-ORG discipline I-ORG construction I-ORG projects I-ORG Grant O 2017ZZ02015 B-AWARD This O research O was O supported O by O the O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81230061 B-AWARD to O WDH O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Beijing I-ORG City I-ORG No. O Z151100003915076 B-AWARD to O WDH O and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFC1303501 B-AWARD and I-AWARD 2016YFC1303504 I-AWARD to O WDH O This O research O was O funded O by O the O Young B-ORG Scientists I-ORG Fund I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 62201405 B-AWARD and O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG under O Grant O No. O 2022M712460 B-AWARD and O the O Key B-ORG R&D I-ORG program I-ORG of I-ORG Hubei I-ORG Province I-ORG under O Grant O No. O 2022BAA049 B-AWARD T.D.M O received O funding O from O the O German B-ORG Research I-ORG Foundation I-ORG DFG O TRR296 O TRR152 B-AWARD SFB1123 B-AWARD and O GRK B-AWARD 2816/1 O the O German B-ORG Center I-ORG for I-ORG Diabetes I-ORG Research I-ORG DZD O e.V O and O the O European B-ORG Research I-ORG Council I-ORG ERC-CoG I-ORG Trusted I-ORG no. O 101044445 B-AWARD This O work O was O supported O in O part O by O Science B-ORG Fund I-ORG for I-ORG Creative I-ORG Research I-ORG Group I-ORG of I-ORG China I-ORG Grant O No. O 61121004 B-AWARD from O the O National O Natural O Science O Foundation O of O China,http://www.nsfc.gov.cn O for O authors O QL, O and O XY O the B-ORG Major I-ORG Research I-ORG Plan I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 91442201 B-AWARD from O the O National O Natural O Science O Foundation O of O China,http://www.nsfc.gov.cn O for O authors O ZZ, O and O XY O and O Science B-ORG Fund I-ORG of I-ORG Hubei I-ORG Province I-ORG Grant O No. O 2015CFB314 B-AWARD from O the O Science O and O Technology O Department O of O Hubei O Province,http://www.hbstd.gov.cn O for O authors O XY, O and O DY O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Chinese B-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG Initiative I-ORG for I-ORG Innovative I-ORG Medicine I-ORG 2017-12M-3-001 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81571587 B-AWARD 81771757 B-AWARD and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFC0901500 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 61801013 B-AWARD 61620106004 I-AWARD and I-AWARD 61522102 O the O National B-ORG Postdoctoral I-ORG Program I-ORG for I-ORG Innovative I-ORG Talents O grant O number O BX201700021 B-AWARD and O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation O grant O number O 2018M640039 B-AWARD This O work O is O partially O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61703207 O 61973160 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20170801 O and O Aeronautical B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 2017ZC52017 O 2018ZC52037 O This O work O was O sponsored O by O grants O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0900504 O NSFC B-ORG project I-ORG U1701235 O Pilot B-ORG National I-ORG Laboratory I-ORG for I-ORG Marine I-ORG Science I-ORG and I-ORG Technology I-ORG Qingdao O BH-A10 O and O Science B-ORG and I-ORG technology I-ORG plan I-ORG project I-ORG of I-ORG Guangzhou I-ORG 201904020042 O The O authors O thank O Prof O George O S. O Tolley O and O Prof O Terry O N. O Clark O from O the O Departments O of O Economics O and O Sociology O of O the O University O of O Chicago O respectively O for O insightful O discussions O and O helpful O suggestions O The O authors O acknowledge O support O from O Beijing B-ORG Planning I-ORG Office I-ORG of I-ORG Philosophy I-ORG and I-ORG Social I-ORG Science I-ORG Key O Program O Grant O No. O 15JDZHA006,http://www.bjpopss.gov.cn B-AWARD National B-ORG Planning I-ORG Office I-ORG of I-ORG Philosophy I-ORG and I-ORG Social I-ORG Science I-ORG of I-ORG China I-ORG Key O Program O Grant O No. O 16ARK001,http://www.npopss-cn.gov.cn B-AWARD and O China B-ORG Scholarship I-ORG Council I-ORG Grant O No. O 201706540024,http://www.csc.edu.cn B-AWARD This O work O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41501028 O the O Key B-ORG Project I-ORG of I-ORG Natural I-ORG Science I-ORG Foundation I-ORG for I-ORG Universities I-ORG of I-ORG Anhui I-ORG Province I-ORG KJ2019A0550 O and O the O Test B-ORG and I-ORG Demonstration I-ORG of I-ORG Agricultural I-ORG Technology I-ORG and I-ORG Service I-ORG Support I-ORG Program I-ORG of I-ORG China I-ORG 2130106-ZJBYD O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O paper O is O supported O by O the B-ORG Water I-ORG Conservancy I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG under O Grant O No. O 2021053 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O No. O 61872171 B-AWARD the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG under O Grant O No. O B210201053 B-AWARD the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG under O Grant O No. O BK20190058 B-AWARD and O the B-ORG Future I-ORG Network I-ORG Scientific I-ORG Research I-ORG Fund I-ORG Project I-ORG under O Grant O No. O FNSRFP-2021-ZD-07 B-AWARD This O research O was O funded O by O the O grants O from O the O Berthold B-ORG Leibinger I-ORG Stiftung I-ORG D12014 O the O Robert O Bosch O Stiftung O the O German B-ORG Federal I-ORG Ministry I-ORG of I-ORG Education I-ORG and I-ORG Research I-ORG BMBF O 13N15770 O the O Deutsche B-ORG Forschungsgemeinschaft I-ORG DFG I-ORG German I-ORG Research I-ORG Foundation I-ORG under I-ORG Germany’s I-ORG Excellence I-ORG Strategy—EXC O 2180—390900677 O and O the O Innovative B-ORG Medicines I-ORG Initiative I-ORG Joint I-ORG Undertaking I-ORG IMI O grant O agreement O n° O 115188 B-AWARD resources O composed O of O financial O contribution O from O EU-FP7 O and O EFPIA O companies O in O kind O contribution O The O authors O thank O Das B-ORG Ministerium I-ORG für I-ORG Wissenschaft I-ORG Forschung I-ORG und I-ORG Kunst I-ORG Baden-Württemberg I-ORG 3R-Netzwerk O BW) O for O the O support O This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2022YFA1304400 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32222071 O 32072388 B-AWARD the O Postdoctoral B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 2021M691083 O Guangdong B-ORG Special I-ORG Branch I-ORG Plan I-ORG for I-ORG Young I-ORG Talent I-ORG with I-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG 2019TQ05N158 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2022A1515010770 O the O Science B-ORG and I-ORG Technology I-ORG Base I-ORG and I-ORG Talent I-ORG Special I-ORG Project I-ORG of I-ORG Guangxi I-ORG Province I-ORG GuikeAD22035012 O and O Guangdong B-ORG Provincial I-ORG Innovation I-ORG Team I-ORG for I-ORG General I-ORG Key I-ORG Technologies I-ORG in I-ORG Modern I-ORG Agricultural I-ORG Industry I-ORG 2019KJ133 O This O research O was O supported O by O AMED B-ORG under O Grant O Number O JP17cm0106504h0002 B-AWARD MEXT B-ORG as I-ORG Priority I-ORG Issue I-ORG on I-ORG Post-K I-ORG computer I-ORG Supercomputer O Fugaku O Project O ID: O hp170227 B-AWARD and O JSPS B-ORG as I-ORG Grant-in-Aid I-ORG for I-ORG Scientific I-ORG Research I-ORG on I-ORG Innovative I-ORG Areas I-ORG 15H0912 O and O Grant-in-Aid O for O Scientific O Research O JP15H05707 O and O JP19K08123 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O European O Regional O Development O Fund O through O the O Centre O of O Excellence O for O Molecular O Cell O Engineering O to O V.H O Molecular O Infection O Medicine O Sweden O MIMS O to O V.H O Swedish B-ORG Research I-ORG council I-ORG 2013-4680 O to O V.H O 2015-04746 B-AWARD to O G.C.A O Ragnar O Söderbergs O Stiftelse O to O V.H O Carl B-ORG Tryggers I-ORG Stiftelse I-ORG för I-ORG Vetenskaplig I-ORG Forskning I-ORG CTS O 14:34 O CTS B-AWARD 15:35 I-AWARD to O G.C.A O Kempestiftelserna B-ORG JCK-1627 O to O G.C.A O Jeanssons O Stiftelser O to O G.C.A O Umeå O Universitet O Insamlingsstiftelsen O för O medicinsk O forskning O to O G.C.A O and O V.H O Umeå O Centre O for O Microbial O Research O UCMR O Gender O Policy O Programme O to O G.C.A O Funding O for O open O access O charge O Swedish O Research O Council O 2015-04746 O to O G.C.A O This O work O was O supported O by O the O Academic B-ORG Scientist I-ORG Fund I-ORG for I-ORG Zhongyuan I-ORG Scholars I-ORG of I-ORG Henan I-ORG Province I-ORG Grant O No. O 2018(185 B-AWARD the O Project B-ORG of I-ORG Central I-ORG Plains I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Leading I-ORG Talents I-ORG of I-ORG Henan I-ORG Province I-ORG Grant O No. O 224200510010 B-AWARD the O Joint B-ORG Fund I-ORG of I-ORG Science I-ORG and I-ORG technology I-ORG R I-ORG I-ORG D I-ORG Program I-ORG of I-ORG Henan I-ORG Province I-ORG Grant O No. O 222103810007 B-AWARD and O the O Key B-ORG scientific I-ORG research I-ORG project I-ORG of I-ORG colleges I-ORG and I-ORG universities I-ORG in I-ORG Henan I-ORG Province I-ORG Grant O No. O 23A220002 B-AWARD This O work O was O supported O by O the O grants O of O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81703803 O and O 81720108033 B-AWARD Guangdong B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2017A030310464 O Foundation B-ORG of I-ORG Educational I-ORG Department I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2016KQNCX026 O and O Guangdong O Key O Laboratory O for O translational O Cancer O research O of O Chinese O Medicine O 2018B030322011 O This O work O was O supported O by O the O following O grants O MOST-105-2314-B-033-001 B-AWARD from O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG ROC O CGH-MR-A10506 B-AWARD from O Cathay B-ORG General I-ORG Hospital I-ORG Taiepi I-ORG Taiwan O and O NCU-LSH-104-A-005 B-AWARD from O the O National B-ORG Central I-ORG University I-ORG and I-ORG Landseed I-ORG Hospital I-ORG Collaborative I-ORG Taoyuan I-ORG Taiwan O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O UK O Medical B-ORG Research I-ORG Council I-ORG MRC O and O Wellcome O grant O ref O 102215/2/13/2 B-AWARD and O the O University O of O Bristol O provide O core O support O for O ALSPAC O The O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG grant O ref O BBI025751/1 B-AWARD BB/I025263/1 B-AWARD provides O funding O for O ARIES O and O the O UK B-ORG Economic I-ORG and I-ORG Social I-ORG Research I-ORG Council I-ORG grant O ref O ES/N000382/1 B-AWARD supported O data O collection O A O comprehensive O list O of O grants O funding O is O available O on O the O ALSPAC O website O http://www.bristol.ac.uk/alspac/external/documents/grant-acknowledgements.pdf O This O publication O is O the O work O of O the O authors O who O will O serve O as O guarantors O for O the O contents O of O this O paper O LDH O MS, O CLR O and O LCH O work O in O a O unit O funded O by O the O University O of O Bristol O and O the O UK O MRC O grant O ref O MC_UU_12013/2 B-AWARD LCH’s O work O has O been O funded O by O the O UK O MRC O grant O ref O MR/M020894/1 B-AWARD The O funding O bodies O were O not O involved O in O the O design O of O the O study O collection O analysis O or O interpretation O of O data O or O in O writing O the O manuscript O This O research O was O supported O by O the O Basic B-ORG Science I-ORG Research I-ORG Program I-ORG through O the O National O Research O Foundation O of O Korea O NRF O funded O by O the O Ministry B-ORG of I-ORG Education O Science O and O Technology O NRF-2013R1A1A2005898 O the O Basic O Science O Research O Program O through O the O National O Research O Foundation O of O Korea O NRF O funded O by O the O Ministry O of O Education O NRF-2019R1I1A1A01041191 O the O Marine O Biotechnology O Program O of O the O Korea O Institute O of O Marine O Science O and O Technology O Promotion O KIMST O funded O by O the O Ministry B-ORG of I-ORG Oceans I-ORG and I-ORG Fisheries I-ORG MOF O No. O 20170431 B-AWARD and O the O National O Institute O of O Biological O Resources O NIBR O funded O by O the O Ministry B-ORG of I-ORG Environment I-ORG MOE I-ORG of I-ORG the I-ORG Republic I-ORG of I-ORG Korea I-ORG NIBR202002109 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Guangxi B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 2021GXNSFBA075027 B-AWARD Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangxi I-ORG Grant O No. O GuiKe B-AWARD AD20297022 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2021M700887 B-AWARD GDAS’ B-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Grant O No. O 2022GDASZH-2022010111 B-AWARD 2021GDASYL-20210103076A B-AWARD Guangxi B-ORG Key I-ORG Laboratory I-ORG of I-ORG Manufacturing I-ORG System I-ORG and I-ORG Advanced I-ORG Manufacturing I-ORG Technology I-ORG Grant O No. O 20-065-40-003Z B-AWARD and O Innovation B-ORG Project I-ORG of I-ORG GUET I-ORG Graduate I-ORG Education I-ORG Grant O No. O 2022YCXS019 B-AWARD 2023YCXS001 B-AWARD Y.-A.S O thanks O National B-ORG Science I-ORG and I-ORG Technology I-ORG Council I-ORG of I-ORG Taiwan I-ORG under O Project O NSTC B-AWARD 111-2221-E-035-054 I-AWARD This O project O was O funded O by O a O Marine B-ORG Environmental I-ORG Observation I-ORG Prediction I-ORG and I-ORG Response I-ORG MEOPAR I-ORG Early-Career O Faculty O Development O Grant O awarded O to O Brett O Favaro O EC1-BF-MUN O Jonathan O A. O Bergshoeff O and O Nicola O Zargarpour O were O supported O by O Ocean O Industry O Student O Research O Awards O from O the O Research B-ORG and I-ORG Development I-ORG Corporation I-ORG of I-ORG Newfoundland I-ORG and I-ORG Labrador I-ORG 5404-1915-101 O and O 5404-1914-101 B-AWARD respectively O Funding O was O also O provided O by O the O Canadian B-ORG Centre I-ORG for I-ORG Fisheries I-ORG Innovation I-ORG H-2015-06 O and O the O Newfoundland B-ORG and I-ORG Labrador I-ORG Department I-ORG of I-ORG Fisheries I-ORG and I-ORG Aquaculture I-ORG currently O Department O of O Fisheries O and O Land O Resources O Fisheries O Development O and O Diversification O Fund O NH-77836 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O the O Portuguese B-ORG Foundation I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG FCT O Project O UID/CVT/0153/2016 B-AWARD LA/P/0045/2020 B-AWARD ALiCE O and O Base O and O Programmatic O UIDB/00511/2020 B-AWARD LEPABE O funded O by O national B-ORG funds I-ORG through I-ORG FCT/MCTES I-ORG PIDDAC O M.C O Coelho O also O acknowledges O financial O support O from O FCT O grant O SFRH/BD/110227/2015 B-AWARD This O work O was O financially O supported O by O the O PON B-AWARD 03 I-AWARD PE_00110_1/ptd1_000410 I-AWARD Titolo B-ORG Sviluppo I-ORG di I-ORG nanotecnologie I-ORG Orientate I-ORG alla I-ORG Rigenerazione I-ORG e I-ORG Ricostruzione I-ORG tissutale I-ORG Implantologia I-ORG e I-ORG Sensoristica I-ORG in I-ORG Odontoiatria/oculistica I-ORG SORRISO O POR O Campania O FESR B-AWARD 2014_2020 I-AWARD “Tecnologie B-ORG abilitanti I-ORG per I-ORG la I-ORG sintesi I-ORG eco-sostenibile I-ORG di I-ORG nuovi I-ORG materiali I-ORG per I-ORG la I-ORG restaurativa I-ORG dentale”—ABILTECH O EU B-ORG funding I-ORG within I-ORG the I-ORG Horizon I-ORG 2020 I-ORG Program O under O the O MSCA-RISE O 2016 O Project O “VAHVISTUS” O Grant O 734759 B-AWARD POR O 2014-2020 O FESR O MISE O Prog O N.F/200004/01-02/X45 B-AWARD Micro-Poli B-ORG Titolo I-ORG Micro-nanodispositivi I-ORG veicolanti I-ORG polifenoli I-ORG isolati I-ORG da I-ORG scarti I-ORG della I-ORG filiera I-ORG olivicola I-ORG come I-ORG nuovi I-ORG integratori I-ORG alimentari I-ORG This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 6217030813 O the O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG 2021A1515010964 O and O the O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Commission I-ORG of I-ORG Shenzhen I-ORG Municipality I-ORG SGDX20190919094803949 O and O JCYJ20200109105810074 B-AWARD The O Neonatal O Pneumococcal O Conjugate O Vaccination O trial O was O funded O by O an O International B-ORG Collaborative I-ORG Project I-ORG Grant I-ORG of I-ORG the I-ORG Wellcome I-ORG Trust I-ORG United I-ORG Kingdom I-ORG 071613/Z/03/Z O and O the B-ORG Australian I-ORG National I-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG NHMRC O 303123 O The O serological O analysis O reported O here O was O supported O by O an O Internal B-AWARD Competitive I-AWARD Research I-AWARD Award I-AWARD Scheme I-AWARD Small I-AWARD Grant I-AWARD 271/F I-AWARD from O the O Papua B-ORG New I-ORG Guinea I-ORG Institute I-ORG of I-ORG Medical I-ORG Research O The O funder O had O no O role O in O study O design O collection O and O analysis O of O data O decision O to O publish O or O writing O of O the O manuscript O The O authors O acknowledge O funding O received O from O E-Da B-ORG Hospital I-ORG EDAHP O 104002 O EDAHP B-AWARD 105002 O E-Da B-ORG Cancer I-ORG Hospital I-ORG EDCHP O 106001 O EDCHP107010 B-AWARD EDCHI109001 B-AWARD EDCHI B-AWARD 110001 O NCKUEDA10805 B-AWARD NCKUEDA10909 B-AWARD and O I-Shou B-ORG University I-ORG ISU-109-IUC-01 O Supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82070948 O Beijing B-ORG Hospitals I-ORG Authority’ I-ORG Ascent I-ORG Plan I-ORG DFL20190201 O and O No. O DFL20220301 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Beijing I-ORG 7222025 O and O Shunyi B-ORG District I-ORG Beijing I-ORG Science I-ORG and I-ORG Technology I-ORG Achievements I-ORG Transformation I-ORG Coordination I-ORG and I-ORG Service I-ORG Platform I-ORG Construction I-ORG Fund I-ORG SYGX202010 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 41673127 B-AWARD and O grants O from O the O Youth B-ORG Innovation I-ORG Promotion I-ORG Association I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG grant O number O 2017478 B-AWARD Financial O support O of O the O Geomicrobiology O Group O is O received O from O the O Natural B-ORG Environment I-ORG Research I-ORG Council I-ORG NE/M010910/1 O TeaSe O NE/M011275/1 B-AWARD COG3 O which O is O gratefully O acknowledged O This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG Basic I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG 973 O project O No. B-AWARD 2010CB530000 O the B-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2016A050502008 B-AWARD the B-ORG National I-ORG Important I-ORG Sci-Tech I-ORG Special I-ORG Projects I-ORG No. O 2012ZX10004220 O and O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81101270 O This O research O was O supported O by O the O French B-ORG Ministry I-ORG of I-ORG Foreign I-ORG Affairs I-ORG project O AGASIA B-AWARD of O the O regional O program O Bio-Asie O PC O the O Special B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG Beijing I-ORG Academy I-ORG of I-ORG Agriculture I-ORG and I-ORG Forestry I-ORG Sciences I-ORG KJCX20151408 O SW O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Project O ID: O 31000013 B-AWARD 31360014 I-AWARD and I-AWARD 31470152 O RZ) O and O the O Thailand B-ORG Research I-ORG Fund I-ORG Grant I-ORG BRG O 5580009 O KDH O entitled O Taxonomy O Phylogeny O and O Biochemistry O of O Thai O Basidiomycetes O The O funders O had O no O role O in O study O design O data O colletion O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O grants O from O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC1309603 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFA0101002 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81170736 B-AWARD 81570715 I-AWARD 81870579 O and O Medical B-ORG Epigenetics I-ORG Research I-ORG Center I-ORG Chinese I-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG 2017PT31036 O 2018PT31021 O This O work O was O supported O by O the O Special B-ORG Fund I-ORG for I-ORG Agro-scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG 201203086-02 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31502142 O and O the B-ORG Foundation I-ORG of I-ORG China I-ORG Three I-ORG Gorges I-ORG Corporation I-ORG JGJ/025 O 2013 O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31402034 B-AWARD the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG Grant O No. O CARS-37 B-AWARD and O the O Innovation B-ORG Project I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG Grant O No. O CAAS-ASTIP-2014-LIHPS-01 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O study O was O support O by O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 71402010 B-AWARD the O Scientific B-ORG Research I-ORG Fund I-ORG of I-ORG Hunan I-ORG Provincial I-ORG Education I-ORG Department I-ORG of I-ORG China I-ORG Grant O No. O 17B019 B-AWARD and O the O Research B-ORG Fund I-ORG of I-ORG Hunan I-ORG Modern I-ORG Enterprise I-ORG Management I-ORG Research I-ORG Center I-ORG of I-ORG China I-ORG Grant O No. O 17qgzd07 B-AWARD credited O to O the O first O author O and O was O supported O by O the O National B-ORG Social I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 15BGL164 B-AWARD credited O to O the O second O author O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O Optical B-ORG Fibre I-ORG Sensing I-ORG Characteristics I-ORG of I-ORG Low I-ORG Pressure I-ORG and I-ORG High I-ORG Radiation I-ORG Environment I-ORG Application I-ORG Test I-ORG Theory I-ORG and I-ORG Test I-ORG Equipment I-ORG XZ202301YD0004C O Development B-ORG of I-ORG a I-ORG New I-ORG Measurement I-ORG Device I-ORG for I-ORG External I-ORG Thread I-ORG Parameters I-ORG Based I-ORG on I-ORG a I-ORG Robotic I-ORG Arm I-ORG AKYZZ2204 O in O part O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O number O 2017YFF0206305 B-AWARD in O part O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG National I-ORG Institute I-ORG of I-ORG Metrology I-ORG program I-ORG of I-ORG China I-ORG grant O number O AKYZD1804-1 B-AWARD It O was O also O supported O by O Key B-ORG Laboratory I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG for I-ORG Optoelectronic I-ORG Measurement I-ORG Technology I-ORG and I-ORG Instrument I-ORG grant O number O GXKF2020001 B-AWARD in O part O by O a O grant O from O the O Ph.D B-ORG Programs I-ORG Foundation I-ORG of I-ORG Henan I-ORG Polytechnic I-ORG University I-ORG B2017-32 O This O work O was O supported O by O the O European B-ORG Research I-ORG Council I-ORG ERC-2015-CoG-682422 O JFAP O the O Deutsche B-ORG Forschungsgemeinschaft I-ORG DFG O FOR B-AWARD 2143 O JFAP O SFB B-AWARD 1315 O JFAP O and O the O Helmholtz O Society O JFAP O CJW O was O supported O by O Human B-ORG Frontier I-ORG Science I-ORG Program I-ORG HFSP O LT000359/2018-L O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 11702113 O and O 51506075 O China O Postdoctoral O Science O Foundation O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG LQ18E030013 O and O LQ18E040001 B-AWARD Educational B-ORG Commission I-ORG of I-ORG Zhejiang I-ORG Province I-ORG of I-ORG China I-ORG Y201636479 O and O Jiaxing O Science O and O Technology O Project O 2018AY11006 O This O study O was O supported O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0201900 O Key B-ORG R&D I-ORG Program I-ORG of I-ORG Xinjiang I-ORG Uygur I-ORG Autonomous I-ORG Region I-ORG 2016B01001-6 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Xinjiang I-ORG Uygur I-ORG Autonomous I-ORG Region I-ORG 2019D01A65 O the B-ORG Basic I-ORG Research I-ORG Operating I-ORG Expenses I-ORG Program I-ORG of I-ORG Public I-ORG Welfare I-ORG Research I-ORG Institute I-ORG from I-ORG Xinjiang I-ORG Uygur I-ORG Autonomous I-ORG Region I-ORG KY2017067).The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Open O access O funding O provided O by O Max O Planck O Society O Funding O was O provided O by O the O National B-ORG Geographic I-ORG Society I-ORG CRE9473-14 O to O EAH O in O 2014 O the O National B-ORG Science I-ORG Foundation I-ORG Grant O BCS1124419 B-AWARD to O EAH O in O 2012–2016 O the O Wenner-Gren B-ORG Foundation I-ORG Grant O 58962 B-AWARD to O CEK O in O 2015 O and O the O Social B-ORG Sciences I-ORG and I-ORG Humanities I-ORG Research I-ORG Council I-ORG of I-ORG Canada I-ORG 767-2012-1903 O to O EAS O in O 2012 O This O work O was O supported O by O the O Taichung B-ORG Veterans I-ORG General I-ORG Hospital O Taichung O Taiwan O grant O number O TCVGH-1113501C B-AWARD and O TCVGH-1123501C B-AWARD National B-ORG Chung I-ORG Hsing I-ORG University I-ORG grant O number O TCVGH-NCHU1110106 B-AWARD and O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Taiwan I-ORG grant O number O MOST B-AWARD 110-2314-B-075A-004-MY3 I-AWARD and O MOST B-AWARD 110-2314-B-005-002 O The O funders O had O no O role O in O the O decision O to O submit O the O manuscript O for O publication O Funded O by O National B-ORG Institutes I-ORG of I-ORG Health O GM122491 B-AWARD VVG O National B-ORG Eye I-ORG Institute O EY011500 B-AWARD VVG O Vanderbilt B-ORG University O Cornelius B-AWARD Vanderbilt I-AWARD Endowed I-AWARD Chair I-AWARD VVG O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O a O grant O from O the O ZonMw B-ORG Microplastics I-ORG and I-ORG Health I-ORG Program—project O number O 458001012 B-AWARD 40-45800-98-118 O BOF-UHasselt B-ORG funding—project O numbers O R9782 B-AWARD and O 22KP16 B-AWARD FWO—project B-ORG number O N15227910 B-AWARD The O research O leading O to O the O results O presented O in O this O publication O was O carried O out O with O infrastructure O funded O by O EMBRC B-ORG Belgium—FWO I-ORG project O GOH3817N B-AWARD This O work O was O supported O by O grants O from O Major B-ORG Program I-ORG on I-ORG Basic I-ORG Research I-ORG Projects I-ORG of I-ORG Yunnan I-ORG Province I-ORG Grant O No. O 2014FC006 B-AWARD the B-ORG Talent I-ORG Project I-ORG of I-ORG Young I-ORG and I-ORG Middle-aged I-ORG Academic I-ORG Technology I-ORG Leadership I-ORG in I-ORG Yunnan I-ORG Province I-ORG Grant O No. O 2013HB073 B-AWARD and O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No.31360549 O the B-ORG Science I-ORG Foundation I-ORG Key I-ORG Project I-ORG of I-ORG Yunnan I-ORG Province I-ORG Department I-ORG of I-ORG Education I-ORG Grant O No. O ZD2013003 B-AWARD This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81400142 B-AWARD The B-ORG Key I-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81230013 B-AWARD and O Health B-ORG Science I-ORG Promotion I-ORG Project I-ORG of I-ORG Beijing I-ORG project O TG-2015-003 B-AWARD This O work O was O supported O by O the B-ORG Beijing I-ORG Hope I-ORG Run I-ORG Special I-ORG Fund I-ORG of I-ORG Cancer I-ORG Foundation I-ORG of I-ORG China I-ORG LC2018A15 O the B-ORG PUMC I-ORG Fund I-ORG of I-ORG the I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 3332018193 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 81641113 O This O study O was O supported O by O grants O from O the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFA0107500 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31961133024 O 81530043 B-AWARD and O 81930085 B-AWARD the B-ORG Scientific I-ORG Innovation I-ORG Project I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Science I-ORG XDA16020403 O XDA16010403 B-AWARD and O the O State O Key O Laboratory O of O Radiation O Medicine O and O Protection O Soochow O University O GZN1201804 O and O GZN1201903 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31500556 O the O Education B-ORG Department I-ORG of I-ORG Hunan I-ORG Province I-ORG 18A152 O the O Forestry B-ORG science I-ORG and I-ORG technology I-ORG plan I-ORG project I-ORG of I-ORG Hunan I-ORG Province I-ORG XKL201743 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG 2019JJ50986 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 2021YFA0717600 O and O NSFC O No. O 62105022 B-AWARD NSFC O No. O U22A2081 B-AWARD M.C O is O also O sponsored O by O the O Beijing B-ORG Nova I-ORG Program I-ORG No. O Z211100002121069 B-AWARD and O Young B-ORG Elite I-ORG Scientists I-ORG Sponsorship I-ORG Program I-ORG by O CAST O No. O YESS20210142 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O nos O 51563022 B-AWARD 21968032 O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG grant O no. O 31920190012 B-AWARD the B-ORG fund I-ORG of I-ORG the I-ORG Double I-ORG First-class I-ORG and I-ORG Characteristic I-ORG Development I-ORG Guide I-ORG of I-ORG Northwest I-ORG Minzu I-ORG University I-ORG grant O no. O 11080316 B-AWARD and O the B-ORG fund I-ORG of I-ORG Teaching I-ORG Quality I-ORG and I-ORG Reform I-ORG Engineering I-ORG Project I-ORG of I-ORG Gansu I-ORG University I-ORG grant O nos O 2019GSSYJXSFZX-01 B-AWARD 2019GSJXCGPY-16 O This O work O was O supported O financially O by O Special B-ORG R&D I-ORG Program I-ORG Project I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Se-enriched I-ORG Industry I-ORG 2019QCY-2.3-01 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31972005 O and O Special B-ORG Fund I-ORG for I-ORG Agro-scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG 201303070 O This O study O was O supported O by O grants O from O the O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health I-ORG #R00MH110343 O PI: O Conserve O Minority O Health O International O Research O Training O MHIRT O Grant O T37-MD001448 B-AWARD from O the O National B-ORG Institute I-ORG on I-ORG Minority I-ORG Health I-ORG and I-ORG Health I-ORG Disparities O and O the O HIV O Dissemination O Science O Training O Program O for O Underrepresented O Investigators O grant O award O R25MH080665 O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH O Bethesda O MD. O The O funders O had O no O role O in O decision O to O publish O or O preparation O of O the O manuscript O 1) O National B-ORG Research I-ORG Foundation I-ORG NRF I-ORG of I-ORG Korea O Grant O Number O NRF-2017R1D1A1B03029368 B-AWARD 2) O the O National O Research O Council O of O Science O O Technology O NST O grant O by O the O Korean O government O MSIT O No. O CMP-16-04-KITECH O 3) O the O Brain B-ORG Pool I-ORG Program I-ORG through I-ORG the I-ORG Korean I-ORG Federation I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Societies I-ORG KOFST I-ORG funded I-ORG by I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG ICT I-ORG No. O 171S-2-3-1807 B-AWARD 4) O the O National O Research O Foundation O of O Korea O NRF O grant O funded O by O the O Korean O government O MSIP O No. O NRF-2017R1A4A1015770 B-AWARD 5) O a O grant O NK218B O from O the O Korea B-ORG Institute I-ORG of I-ORG Machinery I-ORG and I-ORG Materials I-ORG KIMM O 6) O The O Korea O Institute O of O Energy O Technology O Evaluation O and O Planning O KETEP O and O the O Ministry O of O Trade O Industry O O Energy O MOTIE O of O the O Republic O of O Korea O No. O 20172420108700 O This O work O was O supported O by O The B-ORG Special I-ORG Fund I-ORG of I-ORG The I-ORG Pediatric I-ORG Medical I-ORG Coordinated I-ORG Development I-ORG Center I-ORG of I-ORG Beijing I-ORG Hospitals I-ORG Authority I-ORG XTZD20180202 O the O role O of O the O funder O is O the O corresponding O author O Beijing B-ORG Municipal I-ORG Science I-ORG I-ORG Technology I-ORG Commission I-ORG No. O Z171100001017050 B-AWARD the O role O of O the O funder O is O the O corresponding O author O National B-ORG Science I-ORG and I-ORG Technology I-ORG Key I-ORG Projects I-ORG No. O 2017ZX09304029004 B-AWARD the O role O of O the O funder O is O the O coauthor O This O research O was O financially O supported O by O grants O from O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG Grant O no. O 2017JJ1022 B-AWARD the B-ORG National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O nos O 31430088 B-AWARD and O 31210103918 B-AWARD the O Major O Program O of O the O Educational O Commission O of O Hunan O Province O Grant O no. O 17A133 O the O State O Key O Laboratory O of O Developmental O Biology O of O Freshwater O Fish O the O Cooperative O Innovation O Center O of O Engineering O and O New O Products O for O Developmental O Biology O of O Hunan O Province O 20134486 O the O Earmarked O Fund O for O China O Agriculture O Research O System O CARS-46 O and O the O Construction O Project O of O Key O Disciplines O of O Hunan O Province O and O China O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31370323 B-AWARD Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG and I-ORG Scientific I-ORG Research I-ORG Key I-ORG Program I-ORG of I-ORG Beijing I-ORG Municipal I-ORG Commission I-ORG of I-ORG Education I-ORG Project O No. O KZ20130020018 B-AWARD and O the B-ORG Importation I-ORG and I-ORG Development I-ORG of I-ORG High-Caliber I-ORG Talents I-ORG Project I-ORG of I-ORG Beijing I-ORG Municipal I-ORG Institutions I-ORG Project O No. O CIT&TCD201404098 B-AWARD This O work O was O supported O by O grants O from O the O South-Eastern O Norwegian O regional O health O authority O Helse O Sør-Øst I-ORG RHF O Grant O 2011101 B-AWARD This O work O was O also O supported O by O funding O from O a O Sir O Henry O Dale O Fellowship O jointly O funded O by O theWellcome O Trust I-ORG and I-ORG the I-ORG Royal I-ORG Society(Grant O 1047613/Z/15/Z B-AWARD funding O from O theEuropean O Research I-ORG Council(ERC O under O the O European O Union's O Horizon O 2020 O research O and O innovation O programme O grant O no: O 677542 B-AWARD and O theBarts O Charity(Grant O MGU0343 B-AWARD to O JD. O The O funders O did O not O have O any O role O in O study O design O data O collection O data O analysis O interpretation O or O writing O of O the O report O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31701117 O 31970647 B-AWARD National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0901702 O 2017YFC0907503 B-AWARD 13th O Five-Year O Informatization O Plan O of O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG XXH13505-05 O Funding O for O open O access O charge O National O Key O R&D O Program O of O China O 2016YFC0901702 O 2017YFC0907503 O This O study O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2021YFD1600200 O Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG Y2022LM10 O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG 25-LZIHPS-01 O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG of I-ORG MOF I-ORG and I-ORG MARA I-ORG CARS-37 O and O Foundation B-ORG for I-ORG Innovation I-ORG Groups I-ORG of I-ORG Basic I-ORG Research I-ORG in I-ORG Gansu I-ORG Province I-ORG 20JR5RA580 O This O work O was O supported O by O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG O CNPq O process O 446548/2014-6 B-AWARD and O Fundação B-ORG Araucária I-ORG process O 25372 B-AWARD I-AWARD 185/2013 O and O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo I-ORG O FAPESP O process O 2016/50250-1 B-AWARD The O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82104477 O U19A2010 B-AWARD and O 81891012 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2019TQ0044 O and O Innovation B-ORG Team I-ORG and I-ORG Talent I-ORG Cultivation I-ORG Program I-ORG of I-ORG the I-ORG National I-ORG Administration I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG No O ZYYCXTD-D-202209 B-AWARD Sichuan B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 23NSFSC6427 O This O research O was O financially O supported O by O National B-ORG Science I-ORG Fund I-ORG for I-ORG Excellent I-ORG Young I-ORG Scholars I-ORG of I-ORG China I-ORG 41922048 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG 2016YFD0200309 O Outstanding B-ORG Youth I-ORG Scholar I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20180049 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41771297 O 41530856 B-AWARD the O Netherlands B-ORG Organisation I-ORG for I-ORG Scientific I-ORG Research I-ORG No. O 016.Veni.181.078 O Field B-ORG Station I-ORG Alliance I-ORG Project I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG KFJ-SW-YW035-6 O and O Youth B-ORG Innovation I-ORG Promotion I-ORG Association I-ORG of I-ORG CAS I-ORG 2017361 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81201049 O 31871113 O the O Innovation O Project O of O Graduate O School O of O South O China O Normal O University O the B-ORG project I-ORG of I-ORG Shenzhen I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Committee I-ORG JCYJ20160429185235132 O JCYJ20160427192001852 O and O the O Sanming B-ORG Project I-ORG of I-ORG Medicine I-ORG in I-ORG Shenzhen I-ORG SZSM201612079 O SZSM201512009 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O work O was O funded O by O the O European B-ORG Commissions I-ORG EU I-ORG H2020-FETOPEN-2018-2019-2020-01 B-AWARD 861878 O “NeutroCure” O to O Martin O Herrmann O by O the O Volkswagen-Stiftung B-ORG Grant O 97744 B-AWARD to O Martin O Herrmann O by O the O Deutsche B-ORG Forschungsgemeinschaft I-ORG DFG O SCHA B-AWARD 2040/1-1 I-AWARD to O C.S O FOR O 2886 B-AWARD PANDORA B-ORG subproject I-ORG B3 I-ORG to O Martin O Herrmann O CRC1181-261193037 B-AWARD subproject B-ORG C03 I-ORG to O Martin O Herrmann O Our O work O was O funded O by O the O Fonds O de O la O Recherche O Québec-Santé O FRQ-S O Réseau O SIDA/Maladies O infectieuses O and O Thérapie O cellulaire O the O Canadian O Institutes O of O Health O Research O CIHR O Grants O HOP B-AWARD 103230 I-AWARD and O PTJ B-AWARD 166049 O the O Vaccines O O Immunotherapies O Core O of O the O CIHR O Canadian O HIV O Trials O Network O CTN O Grant O CTN B-AWARD 257 I-AWARD and O CTN B-AWARD PT027 O the O Canadian O Foundation O for O AIDS O Research O CANFAR O Grant O 02-512 B-AWARD CIHR O funded O Canadian O HIV O Cure O Enterprise O CanCURE O Team O Grant O HB2-164064 B-AWARD and O the O Chinese B-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG No. O 2018ZX10302104 B-AWARD André O Marette O holds O a O CIHR/Pfizer O research O Chair O in O the O pathogenesis O of O insulin O resistance O and O cardiovascular O complications O and O is O supported O by O a O CIHR O Foundation O Grant O This O work O was O funded O by O a) O the O National B-ORG key I-ORG research I-ORG and I-ORG development I-ORG program I-ORG Grant O Nos O 2018YFA0208503 B-AWARD 2022YFB3606902 B-AWARD b) O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 61890944 B-AWARD 61888102 B-AWARD 92264204 B-AWARD 62274178,61720106013 B-AWARD 61904195 B-AWARD and O 62004214 B-AWARD c) O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Grant O No. O XDB30030000 B-AWARD XDB30030300 B-AWARD M.Z O is O supported O by O The O Royal B-ORG College I-ORG of I-ORG Surgeons I-ORG of I-ORG England O Pump O Priming O Award O 514374 B-AWARD the O Rhiannon B-ORG Jade-Smith I-ORG Trust I-ORG Grant O AL11330011 B-AWARD and O the O Wellcome B-ORG Trust I-ORG Institutional O Strategic O Support O Fund O ISSF3 O Clinical O Primer O Award O 514823 B-AWARD None O of O the O funding O sources O had O any O conflict O of O interest O with O our O work O played O any O role O in O study O design O conduct O data O collection O analysis O and O interpretation O or O the O manuscript O write-up O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 32101708 B-AWARD and O No. O 32001510 B-AWARD the O National B-ORG Peanut I-ORG Industry I-ORG Technology I-ORG System I-ORG Construction I-ORG CARS-13 O National B-ORG Crop I-ORG Germplasm I-ORG Resources I-ORG Center I-ORG NCGRC-2022-036 O National B-ORG Program I-ORG for I-ORG Crop I-ORG Germplasm I-ORG Protection I-ORG of I-ORG China I-ORG 19210163 O Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG No. O 1610172019003 B-AWARD Innovation B-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG 2022-2060299-089-031 O and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2022YFD1200400 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81700553 B-AWARD Stem B-ORG Cell I-ORG and I-ORG Translational I-ORG Research I-ORG the I-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFA0101001 B-AWARD and O the O Postdoctoral B-ORG Research I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 2017M183789 B-AWARD This O project O was O supported O by O the O U.S O National B-ORG Institute I-ORG of I-ORG Diabetes I-ORG and I-ORG Digestive I-ORG and I-ORG Kidney I-ORG Diseases I-ORG grant/award O K08 B-AWARD DK113114 I-AWARD to O G.A.P O the O U.S B-ORG Public I-ORG Health I-ORG Service I-ORG grant/award O P30 B-AWARD DK056338 I-AWARD which O funds O the O Texas O Medical O Center O Digestive O Diseases O Center O the O Maternal O and O Child O Health O Nutrition O Training O Grant O T79 O MC00023 O and O the O National O Institute O of O Health O NIH O grant O R01 O DK124614 O to O A.B.H O the O U.S O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG T32 B-AWARD GM136554 I-AWARD training O grant O to O L.L.N O and O the O Men O of O Distinction O grant/award O to O A.B.H O and O G.A.P O This O research O was O financially O supported O by O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG No. B-AWARD XDA24030102 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. B-AWARD 2016YFD0102002 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. B-AWARD 31771793 O The O funders O had O no O role O in O the O designing O and O conducting O of O this O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O funded O by O VALERE B-ORG Vanvitelli I-ORG per I-ORG la I-ORG Ricerca I-ORG Program I-ORG Adip-Care I-ORG ID263 O the O Campania B-ORG Regional I-ORG Government I-ORG “Lotta I-ORG alle I-ORG Patologie I-ORG Oncologiche” I-ORG iCURE I-ORG CUPB21c17000030007 O MISE B-ORG Nabucco O EU: O BBMRI O CANSERV O project O MUR O PRIN O 2020 I-AWARD CW39SJ O ADM O is O a O PhD O student O enrolled O in O the O translational O medicine O program O at O the O University O of O Campania O “Luigi O Vanvitelli” O This O research O was O funded O by O The O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 51908046 B-AWARD Key O Research O and O Development O Program O of O Shaanxi O Province O Grant O No. O 2019GY-206 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2019M653517 B-AWARD and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No. O 310823172001 B-AWARD This O study O was O supported O by O the O funding O of O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81371394 B-AWARD and O No. O 81511140101 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFC0901504 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Bureau I-ORG Fund I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2014FZ0072 O This O work O was O supported O by O grants O from O Talent B-ORG Project I-ORG of I-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Deparment I-ORG BRA2019160 O Major B-ORG Project I-ORG of I-ORG Changzhou I-ORG Commission I-ORG of I-ORG Health I-ORG ZD201922 O Jiangsu B-ORG natural I-ORG science I-ORG foundation I-ORG general I-ORG project I-ORG BK20191159 O The O APC B-ORG was O partially O funded O by O UTA-Project B-AWARD 4722-22 O D.L O acknowledges O partial O financial O support O from O Centers B-ORG of I-ORG excellence I-ORG with I-ORG BASAL/ANID I-ORG financing O Grant O AFB220001 B-AWARD CEDENNA B-AWARD The O work O of O R.P.R O and O M.V O is O partly O supported O by O the O Regional B-ORG Government I-ORG of I-ORG Madrid I-ORG under O project O S2018/NMT-4321 B-AWARD NANOMAGCOST-CM I-AWARD This O work O was O financially O supported O by O the O Project B-ORG of I-ORG Materials I-ORG and I-ORG Chemical I-ORG Engineering I-ORG First-class I-ORG Undergraduate I-ORG Talent I-ORG Demonstration I-ORG and I-ORG Leading I-ORG Base I-ORG 2020rcsfjd28 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Higher I-ORG Education I-ORG Institutions I-ORG of I-ORG Anhui I-ORG Province I-ORG KJ2021A1132 O KJ2019A0865 B-AWARD Key B-ORG Discipline I-ORG of I-ORG Materials I-ORG Science I-ORG and I-ORG Engineering I-ORG Chizhou I-ORG University I-ORG czxyylxk03 O and O School-level B-ORG key I-ORG projects I-ORG of I-ORG Chizhou I-ORG College I-ORG CZ2021ZRZ12 O This O work O was O supported O by O the O National B-ORG Science I-ORG Research I-ORG and I-ORG Innovation I-ORG Fund I-ORG NSRF I-ORG and I-ORG Prince I-ORG of I-ORG Songkla I-ORG University I-ORG Thailand I-ORG Grant O No. O MED6505096f B-AWARD the O National B-ORG Research I-ORG Council I-ORG of I-ORG Thailand I-ORG Project I-ORG Grant O Number O N41A640071 B-AWARD and O the O 2021 B-ORG PSU-Faculty I-ORG of I-ORG Medicine I-ORG International I-ORG Student I-ORG Graduate I-ORG Scholarships I-ORG Grant O No. O 03/2021 B-AWARD This O study O was O supported O by O the O National B-ORG Scientific I-ORG Foundations I-ORG of I-ORG China I-ORG 81000484 O Natural B-ORG Scientific I-ORG Fundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG LY17H090002 O the O Research B-ORG Fundation I-ORG of I-ORG Zhejiang I-ORG Health I-ORG 2008QN017 O 2016144072 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2013HQ016 O and O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG Shandong I-ORG Province I-ORG 2015GGH318011 O This O project O is O supported O by O Los B-ORG Alamos I-ORG National I-ORG Laboratory I-ORG through O Laboratory O Directed O Research O and O Development O 20110034DR B-AWARD Author O 1); O NSF B-ORG Doctoral I-ORG Dissertation I-ORG Grant O BCS-1232370 B-AWARD and O Wenner-Gren B-ORG Dissertation I-ORG Fieldwork I-ORG Grant O Author O 2); O NIH/NIA B-AWARD R01AG024119-01 I-AWARD Authors O 5 O and O 6). O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 51608058 O 51608057 I-AWARD 51608055 O National O Key O R&D O Program O of O China O grant O number O 2018YFB1600100 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province O grant O number O 2018JJ3550 O the B-ORG education I-ORG department I-ORG of I-ORG Hunan I-ORG province O grant O number O 18B144 O Open O Fund O of O the O Key O Laboratory O of O Road O Structure O and O Material O of O Ministry O of O Transport O Changsha O University O of O Science O O Technology O grant O number O kfj120204 O This O research O was O financially O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O No. O 51663003 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Guizhou I-ORG Province I-ORG [2019]1092 O 2016123 I-AWARD and I-AWARD GZU201625 O C-S O Ha O thanks O for O the O financial O support O from O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG Grant O funded O by O the O Ministry O of O Science O and O ICT O Korea O NRF-2017R1A2B3012961 O Brain B-ORG Korea I-ORG 21 I-ORG Plus I-ORG Program I-ORG 21A2013800002 O This O study O was O funded O by O the O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG grant O BB/L023458/1 B-AWARD the O Medical B-ORG Research I-ORG Council I-ORG grant O MR/K010174/1B B-AWARD and O the O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG grant O HPRU-2012-10080 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 62102118 B-AWARD 62271049 B-AWARD and O U22A2039 B-AWARD Project O of O Educational B-ORG Commission I-ORG of I-ORG Guangdong I-ORG Province I-ORG of I-ORG China I-ORG Grant O No. O 2021KQNCX274 B-AWARD the O Shenzhen B-ORG Colleges I-ORG and I-ORG Universities I-ORG Stable I-ORG Support I-ORG Program I-ORG Grant O No. O GXWD20220811170504001 B-AWARD and O 20220715183602001 B-AWARD This O work O was O supported O by O the O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31701924 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG KJQN201814 O and O the O Fundamental O Research O Funds O for O the O Central O Universities O China O KYZ201609 O The O funders O had O no O role O in O the O experimental O design O data O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG under O the O NSF O EPSCoR O Cooperative O Agreement O No. O EPS-1003897 B-AWARD the O Louisiana B-ORG Board I-ORG of I-ORG Regents I-ORG through O the O Board O of O Regents O Support O Fund O contract O LEQSF(2012-15)-RD-A-05 B-AWARD and O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG grant O No. O GM-119524 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O in O part O by O Taipei B-ORG Medical I-ORG University I-ORG Hospital I-ORG grant O number:108-TMUH-SP-01 O Ministry B-ORG of I-ORG Health I-ORG and I-ORG Welfare I-ORG grant O number O MOHW109-TDU-B-212-114007 B-AWARD and O the O “TMU O Research I-AWARD Center I-AWARD of I-AWARD Cancer I-AWARD Translational I-AWARD Medicine” O from O The B-ORG Featured I-ORG Areas I-ORG Research I-ORG Center I-ORG Program I-ORG within I-ORG the I-ORG framework I-ORG of I-ORG the I-ORG Higher I-ORG Education I-ORG Sprout I-ORG Project I-ORG by I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG MOE O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O Medical B-ORG Technology I-ORG Program I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG 2014KYA202 O Program O of O Innovative B-ORG Research I-ORG Team I-ORG of I-ORG Ningbo I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG 2012B82018-10 O and O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Ningbo O China O 2014C50027 O 2015C50056 B-AWARD Research O in O the O Beuning O laboratory O is O supported O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG R01GM123239 O to O P.J.B O and O the O National B-ORG Science I-ORG Foundation I-ORG MCB-1615946 O to O P.J.B O V.E.C O was O also O funded O by O a O Project B-AWARD SEED I-AWARD scholarship O from O the O American B-ORG Chemical I-ORG Society I-ORG This O research O was O funded O by O the O European O Union O H2020 O Marie O Sklodowska-Curie O MSCA O Innovative O Training O Network O ITN O project O “Biology O and O Technology O of O Reproductive O Health O O REP-BIOTECH O O 675526” O the O Spanish O Ministry O of O Science O Innovation O and O Universities O AGL2015-70140-R O AGL2016-81890-REDT O PGC2018-094781-B-100 O Science B-ORG Foundation I-ORG Ireland I-ORG 13/IA/1983 O the O Irish B-ORG Research I-ORG Council I-ORG GOIPD/2017/942 O and O University B-ORG College I-ORG Dublin I-ORG CDA54580 O We O thank O Roque O Bru’s O lab O a O member O of O Proteored O and O PRB3 O supported O by O grant O PT17/0019 O from O the O PE O I+D+i O 2013-2016 O funded O by O ISCIII O and O ERD O Authors O from O INIA O University O College O Dublin O and O University O of O Hull O are O members O of O the O COST O Action O 16119 O “In O vitro O 3-D O total O cell O guidance O and O fitness O Cellfit)” O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81871994 O and O 81701834 B-AWARD the O Guangdong B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2019B151502063 O and O the O Guangdong B-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Program I-ORG 20190202018 O This O work O was O partially O supported O by O the O United O States O Department O of O Agriculture O National B-ORG Institute I-ORG of I-ORG Food I-ORG and I-ORG Agriculture I-ORG Hatch O Grant O Project O No. O OHO01304 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No.31660648 O the O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O and O Animal O Science O O Technology O Development O PJ01319002 O from O Rural O Development O Administration O Republic O of O Korea O This O work O has O been O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 41504027 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG Grant O No. O 2017CFB520 B-AWARD and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No. O 2042017kf0201 B-AWARD This O work O was O supported O by O the O 2017 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG grant O number O 81700654 B-AWARD 2017 O key B-ORG research I-ORG and I-ORG development I-ORG plan I-ORG of I-ORG Hebei I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG grant O number O 172777169 B-AWARD 2019 O Hebei B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG grant O number19277787D O 2019 O Hebei B-ORG Innovation I-ORG Capability I-ORG Promotion I-ORG Project I-ORG grant O number O 199776249D B-AWARD 2017 O Geriatric O Disease O Prevention O Foundation O of O Hebei O Provincial O Finance O Department O and O 2018 O Specialist O leader O training O Foundation O of O Hebei O Provincial O Government O This O project O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grants O 81670827 O Henan B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Project I-ORG No.152102410085 O and O Zhengzhou B-ORG City I-ORG Project I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG Talents I-ORG Team I-ORG Construction I-ORG Plan I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Team I-ORG No.131PCXTD620 O This O project O was O supported O by O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG No. O 2017ZX09101001-005-003 B-AWARD Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O ZR2019YQ30 B-AWARD ZR2019YQ24 B-AWARD Taishan B-ORG Scholar I-ORG Program I-ORG No. O qnts20161035 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81972892 B-AWARD 81573614 B-AWARD 81673364 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O BK20150702 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Development I-ORG Fund I-ORG of I-ORG Nanjing I-ORG Medical I-ORG University I-ORG 2016NJMU105 O and O A O Project O Funded O by O the O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG KYCX17_0674 O KYCX19_0644 B-AWARD This O research O was O funded O by O Key O Laboratory O of O Aquatic O Product O Processing O Ministry O of O Agriculture O and O Rural O Affairs O China O grant O number O NYJG201701 O Henan B-ORG Provincial I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology O grant O number O 162300410071 B-AWARD China B-ORG Agriculture I-ORG Research I-ORG System O grant O number O CRAS-46 B-AWARD and O Henan B-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology O grant O number O 13480058 B-AWARD This O work O was O funded O by O The B-ORG Ministry I-ORG of I-ORG Agriculture I-ORG Species I-ORG Resource I-ORG Production I-ORG Project O 15RZZY-29 O The B-ORG Fundamental I-ORG Scientific I-ORG Research I-ORG Funds I-ORG for I-ORG CATAS-TCGRI I-ORG 1630032013012 O and O The B-ORG Special I-ORG Fund I-ORG for I-ORG AGRO-Scientific I-ORG Research I-ORG in I-ORG The I-ORG Public I-ORG Interest O 201303117 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Funding O for O the O Africa O Health O Research O Institute(AHRI O and O Population-based O HIV O Survey O was O received O from O the O Wellcome B-ORG Trust I-ORG UK I-ORG 082384/Z/07/Z O F.T O was O supported O by O a O South B-ORG African I-ORG Medical I-ORG Research I-ORG Council I-ORG Flagship I-ORG grant O MRC-RFA-UFSP-01– O 2013/UKZNHIVEPI O an O R01 O grant O from O the O National O Institute O of O Child O Health O and O Human O Development O 1R01HD084233–01 O and O UK B-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG Newton I-ORG Advanced I-ORG Fellowship I-ORG NA150161 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O this O manuscript O This O work O was O funded O by O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG No. O 2012ZX09102301-009 B-AWARD Graduate B-ORG Innovation I-ORG Research I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Sci-Tech I-ORG University I-ORG YCX16035 O Science B-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Sci-Tech I-ORG University I-ORG 15042169-Y O and16042186-Y O This O study O was O supported O by O Special B-ORG project I-ORG for I-ORG clinical I-ORG research I-ORG of I-ORG Shanghai I-ORG Muncipal I-ORG Health I-ORG Bureau I-ORG 20204Y0459 O the O Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG Platform I-ORG Project I-ORG 18DZ2291100 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81870785 O 82071134 B-AWARD This O work O was O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG for I-ORG Excellent I-ORG Young I-ORG Scholars I-ORG 2020JJ3056 O to O YX O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O grants O 81870577 O 81670772 B-AWARD to O YX, O and O 81600649 B-AWARD to O BH] O and O the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC1315603 O to O GH O Above O funding O sources O had O no O role O in O study O design O data O collection O data O analysis O data O interpretation O or O writing O of O the O manuscript O This O work O was O funded O by O Proyectos B-ORG de I-ORG Investigacion I-ORG en I-ORG Salud I-ORG FIS O PI19-00584 B-AWARD and O PI22/01404 B-AWARD funded O by O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III O TIRONET2-CM B-AWARD B2017/BMD-3724 I-AWARD iTIRONET I-AWARD P2022/BMD7379 I-AWARD funded O by O Comunidad B-ORG de I-ORG Madrid O and O co-financed O by O FEDER B-ORG funds O to O Mónica O Marazuela O Azpiroz O This O work O was O financially O supported O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 2018ZY38 B-AWARD and O No. O 2016ZCQ02 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2017M620650 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31800594 B-AWARD and O the O Special B-ORG Fund I-ORG for I-ORG Beijing I-ORG Common I-ORG Construction I-ORG Project I-ORG No. O 2016GJ-03 B-AWARD DRC O is O a O Cancer B-ORG Institute I-ORG NSW I-ORG Fellow O a O National O Breast O Cancer O Foundation O Fellow O and O was O previously O a O Science B-ORG Foundation I-ORG Ireland/Marie O Curie O Actions O Fellow O WK O was O supported O by O an O Irish B-ORG Cancer I-ORG Society I-ORG CCRC O BREAST-PREDICT O grant O CCRC13GAL O The O research O findings O presented O in O this O manuscript O were O funded O by O Science O Foundation O Ireland O 14/IA/2395 O and O Science O Foundation O Ireland O – O Marie O Curie O Actions O COFUND O 11/SIRG/B2157 O and O Cancer O Institute O NSW O 13/FRL/1-02 O JFH O KJM O JW O and O RS O were O recipients O of O an O Australian O Postgraduate O Award O This O study O was O supported O by O The B-ORG Guangdong I-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG 2015A020209037 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hainan I-ORG Province I-ORG China I-ORG 2017CXTD021 O The B-ORG Guangdong I-ORG province I-ORG marine I-ORG fishery I-ORG science I-ORG and I-ORG technology I-ORG and I-ORG industrial I-ORG development I-ORG of I-ORG special I-ORG scientific I-ORG and I-ORG technological I-ORG research I-ORG and I-ORG development I-ORG projects I-ORG A201601A08 O This O work O was O supported O by O Fujian B-ORG Provincial I-ORG Social I-ORG Science I-ORG Research I-ORG Base I-ORG Major I-ORG Project I-ORG FJ2018JDZ064 O to O YW, O Research B-ORG Center I-ORG for I-ORG Targeted I-ORG Poverty I-ORG Alleviation I-ORG and I-ORG Anti-Poverty I-ORG Returning I-ORG A I-ORG New-Style I-ORG Think I-ORG Tank I-ORG of I-ORG Colleges I-ORG and I-ORG Universities I-ORG of I-ORG Fujian I-ORG Province I-ORG Fujian O Teaching I-AWARD and I-AWARD Research I-AWARD 2018 I-AWARD No. I-AWARD 50) O to O YW O and O National B-ORG Social I-ORG Science I-ORG Fund I-ORG Project I-ORG Study I-ORG on I-ORG the I-ORG Economic I-ORG Consequences I-ORG and I-ORG Spillover I-ORG Effects I-ORG of I-ORG the I-ORG Implementation I-ORG of I-ORG the I-ORG Poverty I-ORG Alleviation I-ORG Social I-ORG Responsibility I-ORG of I-ORG Listed I-ORG Companies I-ORG 19BGL087 O to O BX. O This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82171076 O 82071852 B-AWARD Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG 20Z11900400 O Shanghai B-ORG Hospital I-ORG Development I-ORG Center I-ORG SHDC2020CR2040B O SHDC2020CR5014 B-AWARD the O National O Natural O Science O Foundation O of O China O 81771739 O the O Program O for O Professor O of O Special O Appointments O Eastern O Scholar O at O Shanghai O Institutions O of O Higher O Learning O the O Top O Young O Talent O Program O of O Shanghai O the O Innovative O Research O Team O of O High‐level O Local O Universities O in O Shanghai O Shanghai O Sailing O Program O 22YF1435400 O and O the O National O Natural O Science O Foundation O of O China O 8220040737 O This O study O was O supported O by O research O grants O from O the O Wellcome B-ORG Trust I-ORG to O C.R O 095623/Z/11/Z O the O British B-ORG Heart I-ORG Foundation I-ORG to O C.R O and O A.F O PG/18/85/34127 O the O Fondazione B-ORG Cariplo I-ORG 2018-0298 O and O the O Fondazione B-ORG Associazione I-ORG Italiana I-ORG per I-ORG la I-ORG Ricerca I-ORG sul I-ORG Cancro I-ORG AIRC O to O A.F O 22905 O The O funders O had O no O role O in O the O study O design O data O collection O and O interpretation O nor O the O decision O to O submit O the O work O for O publication O Support O for O this O work O was O provided O by O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG FRN146331 O R. B-ORG Howard I-ORG Webster I-ORG Foundation I-ORG F13-00031 O and O W. O Garfield O Weston O Foundation/Brain O Canada I-ORG Foundation I-ORG F13-02369 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG CN) I-ORG 31301231 B-AWARD Xumeng O Li O The B-ORG Hunan I-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 14JJ4037 B-AWARD Xumeng O Li O Hunan B-ORG province I-ORG colleges I-ORG and I-ORG universities I-ORG scientific I-ORG research I-ORG projects I-ORG 15C0657 B-AWARD Xiaohui O Wang O The B-ORG State I-ORG Scholarship I-ORG Fund I-ORG 201408430018 B-AWARD Xumeng O Li O The B-ORG Open I-ORG Project I-ORG Program I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Hybrid I-ORG Rice I-ORG 2016KF04 B-AWARD Xumeng O Li O National O Science O and O Technology O Projects O for O Rice O Fertility O 2013BAD07B11 O Huang O Huang O This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG province I-ORG China I-ORG 2015J06006 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31571732 O and O 31101196 B-AWARD and O the O Earmarked B-ORG Fund I-ORG for I-ORG the I-ORG Modern I-ORG Agriculture I-ORG Technology I-ORG of I-ORG China I-ORG CARS-20 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Funded O by O University B-ORG Nursing I-ORG Program I-ORG for I-ORG Young I-ORG Scholars I-ORG with I-ORG Creative I-ORG Talents I-ORG in I-ORG Heilongjiang I-ORG Province I-ORG UNPYSCT-2017149 B-AWARD Dr. O Zhang O Lei O Basic B-ORG scientific I-ORG research I-ORG service I-ORG fee I-ORG project I-ORG of I-ORG Heilongjiang I-ORG provincial I-ORG undergraduate I-ORG universities I-ORG 2018-KYYWF-0937 B-AWARD Wang O Bin O Heilongjiang B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG CN) O YQ2019F018 B-AWARD Dr. O Zhang O Lei O Special B-ORG Doctor I-ORG Scientific I-ORG Research I-ORG Fund I-ORG Launch I-ORG Project I-ORG of I-ORG Jiamusi I-ORG University I-ORG Research B-AWARD on I-AWARD Privacy I-AWARD Protection I-AWARD of I-AWARD User I-AWARD Collaboration I-AWARD in I-AWARD Location I-AWARD Services I-AWARD Dr. O Zhang O Lei O Post O Doctoral O Fund O Project O in O China O 2019M661260 O Dr. O Zhang O Lei O Excellent O Discipline O Team O Project O of O Jiamusi O University O JDXKTD-2019008 O Dr. O Zhang O Lei O and O Wang O Bin O This O study O was O supported O by O the O Scientific B-ORG and I-ORG technological I-ORG innovation I-ORG joint I-ORG capital I-ORG projects I-ORG of I-ORG Fujian I-ORG Province I-ORG 2016Y9031 O Construction B-ORG Project I-ORG of I-ORG Fujian I-ORG Province I-ORG Minimally I-ORG Invasive I-ORG Medical I-ORG Center I-ORG No. O 2017]171 O The B-ORG second I-ORG batch I-ORG of I-ORG special I-ORG support I-ORG funds I-ORG for I-ORG Fujian I-ORG Province I-ORG innovation I-ORG and I-ORG entrepreneurship I-ORG talents I-ORG 2016B013 O The O funding O body O had O no O role O in O the O study O design O data O collection O and O analysis O or O preparation O of O manuscript O This O study O is O financially O supported O by O the O Innovation B-ORG and I-ORG Entrepreneurship I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O JSSCB20211065 B-AWARD the O High-level B-ORG Talent I-ORG Introduction I-ORG Project I-ORG of I-ORG Yangzhou I-ORG University I-ORG 137012062 O and O the O Jiangsu B-ORG Postgraduate I-ORG Practice I-ORG Innovation I-ORG Project I-ORG SJCX22_1744 O The O Melbourne O InFANT O Program O was O supported O by O project O grants O from O the O Australian O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG NHMRC O #425801 O 1008879 O AC O is O supported O by O a O DECRA O fellowship O DE160100141 O from O the O Australian B-ORG Research I-ORG Council O AC O is O a O researcher O within O a O NHMRC O Centre O for O Research O Excellence O in O Obesity O Policy O and O Food O Systems O APP1041020 O KDH O is O supported O by O an O Australian O Research O Council O Future O Fellowship O FT130100637 O O Honorary O National B-ORG Heart I-ORG Foundation I-ORG of I-ORG Australia I-ORG Future O Leader O Fellowship O 100370).Funding O bodies O had O no O role O in O the O design O of O the O study O data O collection O data O analysis O writing O the O manuscript O or O interpretation O of O results O This O work O was O supported O by O the O Hallym B-ORG University I-ORG Research I-ORG Fund I-ORG grant O no. O HURF-2017-20 B-AWARD the O Bio O O Medical O Technology O Development O Program O of O the O National B-ORG Research I-ORG Foundation I-ORG funded O by O the O Korean O government O MSIT O grant O no. O NRF B-AWARD 2017M3A9E8033225 O a O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG Grant I-ORG funded O by O the O Korean O Government O grant O no. O NRF I-AWARD 2017R1C1B5017879 O and O a O 2018 B-AWARD Research I-AWARD Grant I-AWARD from O Kangwon B-ORG National I-ORG University O HURF-2017-20 O and O NRF O 2017M3A9E8033225 O provided O the O necessary O resources O ELISA O kits O and O QFT-GIT O assay O for O collection O of O data O NRF O 2017R1C1B5017879 O and O 2018 O Research O Grant O from O Kangwon O National O University O provided O professional O staff O suitable O for O the O analysis O and O interpretation O of O data O This O project O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31760732 I-AWARD and I-AWARD 31960698 O the O Science B-ORG and I-ORG Technology I-ORG Fund I-ORG of I-ORG Guizhou I-ORG Province I-ORG No. O QKHJ-2020-1Y134]，the O Transformation B-ORG and I-ORG Industrialization I-ORG of I-ORG Scientific I-ORG and I-ORG Technological I-ORG Achievements I-ORG of I-ORG Guizhou I-ORG Province I-ORG No. O QKHKY-2017-055 O and O the O Agricultural B-ORG Research I-ORG Project I-ORG of I-ORG Guizhou I-ORG Province I-ORG No. O QKHZC-2016-2588 O This O study O is O financially O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grants I-ORG 2019YFA0906004 O the B-ORG National I-ORG Foundation I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Project O No. O 11872200 B-AWARD Guangdong B-ORG Foundation I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Project O No. O 2017B030301018 B-AWARD Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Committee I-ORG Project O No. O JSGG20200225151916021 B-AWARD This O work O was O supported O in O part O by O grants O from O NCIDEA B-ORG 001 O the O US O National B-ORG Science I-ORG Foundation I-ORG IIP-0839478 O and O IIP-1026703 B-AWARD and O the O US O National B-ORG Institutes I-ORG of I-ORG Health I-ORG 1R43HL096177-01A1 O This O work O was O supported O by O the O Hainan B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Special I-ORG Fund I-ORG ZDYF2021XDNY121 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31960064 O and O the O Developing B-ORG Bioinformatics I-ORG Platform I-ORG in I-ORG the I-ORG Hainan I-ORG Yazhou I-ORG Bay I-ORG Seed I-ORG Lab I-ORG B21HJ0001 O This O study O was O financially O supported O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Number O 81472462 B-AWARD and I-AWARD 81772797 O Medical B-ORG Guidance I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG 15411966400 O Shanghai B-ORG Municipal I-ORG Education I-ORG Commission I-ORG Gaofeng I-ORG Clinical I-ORG Medicine I-ORG Grant I-ORG Support I-ORG 20172007 O and O Guangci B-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG Training I-ORG Program I-ORG GCQN-2018-B11 O The O funding O bodies O had O no O role O in O study O design O collection O analysis O or O interpretation O of O data O or O in O writing O the O manuscript O This O work O was O supported O by O the O National B-ORG Major I-ORG Scientific I-ORG Instruments I-ORG Development I-ORG Project I-ORG 2012YQ03026007 O 2013YQ030923 I-AWARD to O WL O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81271511 O to O WL, O 31300895 B-AWARD to O YZ, O 81421061 B-AWARD to O LH O the O Shanghai B-ORG Municipal I-ORG Commission I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG 14JC1403700 O to O WL O “Eastern B-ORG Scholar” I-ORG project I-ORG supported I-ORG by I-ORG Shanghai I-ORG Municipal I-ORG Education I-ORG Commission I-ORG the I-ORG fund I-ORG of I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG 15JCZZ02 O to O WL O National B-ORG Key I-ORG Laboratory I-ORG of I-ORG Human I-ORG Factors I-ORG Engineering I-ORG Open I-ORG Fund I-ORG Project I-ORG HF2013-K-02 O to O WL O National B-ORG Key I-ORG Laboratory I-ORG Grant I-ORG of I-ORG Human I-ORG Factors I-ORG Engineering I-ORG SYFD140051801 O to O XC) O and O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2011CB711000 O to O XC O This O work O was O supported O by O the O Natural B-ORG Sciences I-ORG and I-ORG Engineering I-ORG Research I-ORG Council I-ORG of I-ORG Canada I-ORG RGPIN O 04282-2014 B-AWARD to O P.O O a O Canadian B-ORG Cancer I-ORG Society I-ORG Research I-ORG Institute I-ORG innovation O grant O 704324 O to O P.O O and O S.S.C.L O the O Canada B-ORG Foundation I-ORG for I-ORG Innovation I-ORG 229917 O to O P.O O the O Ontario O Research O Fund O 229917 O to O P.O O Canada B-ORG Research I-ORG Chairs I-ORG 950-229917 O to O P.O O and O the O Canadian O Breast O Cancer O Foundation O to O S.S.C.L O This O research O was O supported O at O least O in O part O through O the O Georgia B-ORG Cancer I-ORG Center I-ORG Paceline I-ORG funding I-ORG mechanism I-ORG principal O investigator O Meng-Han O Tsai O MCGFD01050 B-AWARD Justin O X. O Moore O was O supported O by O the O National B-ORG Institute I-ORG on I-ORG Minority I-ORG Health I-ORG and I-ORG Health I-ORG Disparities I-ORG of I-ORG the I-ORG National I-ORG Institutes I-ORG of I-ORG Health I-ORG under O Award O Number O K01MD015304 B-AWARD The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O National O Institutes O of O Health O Moreover O Avirup O Guha O is O supported O by O American B-ORG Heart I-ORG Association-Strategically O Focused O Research O Network O Grant O in O Disparities O in O Cardio-Oncology O #847740 O 863620 B-AWARD This O study O was O supported O by O a O grant O 2017RIA2B3002971 O from O the O Basic O Science O Research O Program O through O the O National O Research O Foundation O of O Korea O NRF O funded O by O the O Ministry B-ORG of I-ORG Science I-ORG ICT I-ORG and I-ORG Future I-ORG Planning O a O Korea B-ORG Basic I-ORG Science I-ORG Institute I-ORG grant O C33730 O and O the O Bio-industry O Technology O Development O Program O 315021-04 O through O the O Korean O Institute O of O Planning O and O Evaluation O for O Technology O in O Food O Agriculture O Forestry O and O Fisheries O iPET O funded O by O the O Ministry B-ORG of I-ORG Agriculture I-ORG Food I-ORG and I-ORG Rural I-ORG Affairs O Republic O of O Korea O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O Agencia B-ORG Nacional I-ORG de I-ORG Promoción I-ORG Científica I-ORG y I-ORG Tecnológica I-ORG and O Fondo B-ORG para I-ORG la I-ORG Investigación I-ORG Científica I-ORG y I-ORG Tecnológica O grant O numbers O PICT B-AWARD 2017-0976 I-AWARD and I-AWARD PICT I-AWARD 2019-1662 I-AWARD to O P.A O and O PICT B-AWARD 2019-0763 I-AWARD to O A.W O Consejo B-ORG Nacional I-ORG de I-ORG Investigaciones I-ORG Científicas I-ORG y I-ORG Técnicas O grant O number O PIP B-AWARD 2021-2023 I-AWARD 0505 I-AWARD code I-AWARD 11220200100505CO I-AWARD to O N.B.C O and O Universidad B-ORG Nacional I-ORG de I-ORG Rosario O grant O number O BIO573 B-AWARD to O P.A O The O APC O was O not O funded O The O work O was O supported O by O a O Grant O No.09320503600 B-AWARD from O Shanghai B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission O Grants O No.B-9500-10-0004 B-AWARD No.13YZ098 B-AWARD and O No.ZZhy12028 B-AWARD from O Shanghai B-ORG Municipal I-ORG Education I-ORG Commission O and O Grants O No.31271830 B-AWARD and O No.31671946 B-AWARD from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O The O funding O agencies O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the O Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG JCYJ20160427151920801 O and O JCYJ20160427153524391 B-AWARD the O Shenzhen B-ORG Healthcare I-ORG Research I-ORG Project I-ORG 201601029 O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG 2016ZX10004222 O G.F.G O is O a O leading B-ORG principal I-ORG investigator I-ORG of I-ORG the I-ORG NSFC I-ORG Innovative I-ORG Research I-ORG Group I-ORG 81621091 O Y.B O is O supported O by O the O Youth B-ORG Innovation I-ORG Promotion I-ORG Association I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG CAS O 2017122 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 32170401 B-AWARD and O 31270406 B-AWARD the O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG China I-ORG Grant O No. O 2023A1515012805 B-AWARD and O 2019A1515011236 B-AWARD and O the O Forestry B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG Grant O No. O 2020KJCX013 B-AWARD 2021-KJXM-14 B-AWARD and O 2021-KYXM-01 B-AWARD This O study O was O supported O by O the O “Climbing O Plan” O Guangdong B-ORG University I-ORG Student I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Cultivation I-ORG Special I-ORG Fund I-ORG Projects I-ORG grant O number O pdjh2017b0421 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG Guangzhou I-ORG Medical I-ORG University I-ORG grant O number O 2016A046 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG grant O number O 2015A030313684 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81700004 B-AWARD The O funding O funders O mentioned O above O had O role O in O study O design O experimental O development O data O collection O analysis O and O interpretation O and O manuscript O writing O This O work O was O supported O by O the O CAMS B-ORG Initiative I-ORG for I-ORG Innovative I-ORG Medicine I-ORG 2016-I2M-1-019 O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Projects I-ORG 2018ZX09738003-007 O Major B-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG of I-ORG Yunnan I-ORG Province I-ORG 2019ZF001 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81971947 O Talent B-ORG development I-ORG project I-ORG D2017003 O The O authors O declare O no O conflicts O of O interest O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 41763019 B-AWARD and O 42267014 B-AWARD China B-ORG scholarship I-ORG for I-ORG overseas I-ORG study I-ORG Grant O No. O 201806675020 B-AWARD and O the O Key B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Guizhou I-ORG Province I-ORG Grant O No. O JZ B-AWARD 2014 I-AWARD 2006 O This O work O was O supported O by O the O Defense B-ORG Advanced I-ORG Research I-ORG Projects I-ORG Agency I-ORG purchase O request O no. O HR0011515303 B-AWARD contract O no. O HR0011-15-C-0091 B-AWARD the O Army O Research O Office O under O the O Multidisciplinary B-ORG University I-ORG Research I-ORG Initiatives I-ORG MURI O award O W911NF-12-1-0390 B-AWARD the O United B-ORG States I-ORG Department I-ORG of I-ORG Energy I-ORG DE-SC0012627 O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG T32GM100842 O 5R01DE024468 B-AWARD R01GM121950 B-AWARD and O Sub_P30DK036836_P&F B-AWARD the O National B-ORG Science I-ORG Foundation I-ORG 1457695 O and O NSFOCE-BSF O 1635070 B-AWARD the O Human B-ORG Frontiers I-ORG Science I-ORG Program I-ORG RGP0020/2016 O and O the O Boston O University O Interdisciplinary O Biomedical O Research O Office O A.R.P O is O supported O by O a O Howard O Hughes O Medical O Institute O Gilliam O Fellowship O and O a O National O Academies O of O Sciences O Engineering O and O Medicine O Ford O Foundation O Predoctoral O Fellowship O The O funders O have O no O role O in O designing O the O experiment O and O publication O of O the O manuscript O This O study O was O financially O supported O by O a O project O from O the O Korea B-ORG Technology I-ORG and I-ORG Information I-ORG Promotion I-ORG Agency I-ORG for I-ORG SMEs I-ORG TIPA O C0541691 B-AWARD a O grants O from O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF-2019R1A2C1009006 O and O projects O from O the O Korea B-ORG Institute I-ORG of I-ORG Toxicology I-ORG KK-1908-03 O and O KK-1811-03 B-AWARD This O study O was O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2017A030313557 B-AWARD Guangzhou B-ORG Health I-ORG Bureau I-ORG No. O 20171A011256 B-AWARD and O Guangzhou B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG No. O 201607010316 B-AWARD Professor O Arminas O Ragauskas O is O an O inventor O of O patented O the O non-invasive O ICP O measurement O method O and O a O shareholder O of O Vittamed O Neuroscience O Waltham O MA, O USA O AR, O LB, O MD O and O RZ O have O received O financial O support O from O Vittamed O Neuroscience O Waltham O MA, O USA O AR, O RZ, O VM, O DR O and O KP O have O received O financial O support O from O European O Commission’s O Seventh B-ORG Framework I-ORG Programme I-ORG project O ‘BrainSafe’ O grant O no. O 232545 B-AWARD LB, O AR, O JF, O JK, O ER, O VM O and O RZ O have O received O financial O support O from O Lithuanian-Swiss B-ORG Programe I-ORG project O ‘BrainCare’ O grant O no. O CH-3SMM-01/06 B-AWARD LB, O LS O and O IJ O have O received O financial O support O from O European B-ORG Social I-ORG Fund I-ORG under O the O Global O Grant O measure O grant O no. O VP1-3.1-SMM-07-K-03-080 B-AWARD EB O has O received O financial O support O from O National B-ORG Space I-ORG Biomedical I-ORG Research I-ORG Institute I-ORG via O NASA B-AWARD NCC9-58 O and O Center O for O Space O Medicine O Baylor O College O of O Medicine O No O funding O bodies O had O any O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61703328 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2018M631165 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O XJJ2018254 B-AWARD This O work O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U1936106 B-AWARD in O part O by O the O National O Natural O Science O Foundation O of O China O U19A2080 B-AWARD in O part O by O the O CAS B-ORG Strategic I-ORG Leading I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG XDA27040303 B-AWARD XDA18040400 B-AWARD XDB44000000 B-AWARD and O in O part O by O the O High B-ORG Technology I-ORG Project I-ORG 31513070501 B-AWARD and O 1916312ZD00902201 B-AWARD This O work O was O supported O by O Brazilian O Funding O Agencies O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG CAPES O AUX-PE-PARASITOLOGIA B-AWARD 1348/2011 O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq O 309011/2013-2 B-AWARD and O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG Minas I-ORG Gerais I-ORG FAPEMIG O CDS-RED-00013-14 B-AWARD CVZ-PPM-00784-15 O This O research O was O funded O by O Jiangsu B-ORG Provincial I-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Independent I-ORG Innovation I-ORG Fund I-ORG Project O CX(21)3023 B-AWARD National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China O 2019YFD1000101 B-AWARD Jiangsu B-ORG Agricultural I-ORG Industry I-ORG Technology I-ORG System O JATS B-AWARD 2022]457 I-AWARD DF, O JR O and O GM O are O supported O by O theBritish O Heart I-ORG Foundation“Unravelling O mechanisms O of O stem O cell O depletion O for O preservation O of O regenerative O fitness O in O patients O with O diabetes” O programme O grant O RG/13/17/30545 O SS O is O supported O by O theHeart O Research I-ORG UK“Unravelling O the O molecular O mechanisms O of O human O adventitial O pericytes O for O clinical O translation” O project O grant O UK-RG2639 O This O article O received O also O the O support O of O theBritish O Heart I-ORG Foundation I-ORG Research I-ORG Centres I-ORG for I-ORG Excellence I-ORG network(RM/13/2/30158 O This O work O was O mainly O supported O by O the O U.S B-ORG Department I-ORG of I-ORG Energy I-ORG Office I-ORG of I-ORG Science I-ORG under O Award O No. O DE-SC0022006 B-AWARD crystal O growth O and O electronic O magnetic O and O thermal O property O measurements O F. O W O acknowledges O the O support O from O NSF B-ORG under O award O MRI O 2117129 B-AWARD for O single O crystal O XRD O and O structure O refinements O J. O S O acknowledges O the O support O from O NIH B-ORG under O award O P20GM103429 B-AWARD for O powder O XRD O This O work O was O supported O by O the O Research O Program O to O Solve O Social O Issues O of O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O funded O by O the O Ministry O of O Science O and O Information O and O Communication O Technology O ICT O NRF-2017M3A9E4061992 O the O Agency B-ORG for I-ORG Defense I-ORG Development I-ORG UE202026GD O and O the O Institute B-ORG of I-ORG Biomedical I-ORG Science I-ORG and I-ORG Food I-ORG Safety I-ORG IBF O K2009831 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O BGI-Shenzhen O provided O support O in O the O form O of O salaries O for O authors O YS, O YH, O GH, O X. O Zhang O ZR, O X. O Zhao O CG, O XL, O XY O and O QS O but O did O not O have O any O additional O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O specific O roles O of O these O authors O are O articulated O in O the O ‘author O contributions’ O section O Our O work O was O financially O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.31370047 O Special B-ORG Project I-ORG on I-ORG the I-ORG Integration I-ORG of I-ORG Industry I-ORG Education I-ORG and I-ORG Research I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2013B090800017 B-AWARD Shenzhen B-ORG Special I-ORG Program I-ORG for I-ORG Future I-ORG Industrial I-ORG Development I-ORG No. O JSGG20141020113728803 B-AWARD Shenzhen B-ORG Dapeng I-ORG Special I-ORG Program I-ORG for I-ORG Industrial I-ORG Development I-ORG No. O KY20160102 B-AWARD and O Special B-ORG Fund I-ORG for I-ORG State I-ORG Oceanic I-ORG Administration I-ORG Scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG No. O 201305018 B-AWARD This O work O was O supported O in O part O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2017YFD0201501 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31871524 B-AWARD Six B-ORG Talent I-ORG Peaks I-ORG Project I-ORG in I-ORG Jiangsu I-ORG Province I-ORG Grant O No. O XYDXX-049 B-AWARD the O Priority O Academic O Program O Development O of O Jiangsu O Higher O Education O Institutions O PAPD O the O 111 O Project O B16026 O and O the O Primary O Research O O Development O Plan O of O Jiangsu O Province O of O China O BE2017385 O This O study O was O supported O by O grants O from O Scientific B-ORG and I-ORG Technological I-ORG Innovation I-ORG Act I-ORG Program I-ORG of I-ORG Shanghai I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG 20JC1411900 O GYY O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2019YFA0112000 O YT O 2022YFA1603600 B-AWARD ZZ O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82071284 O YT O 81974179 B-AWARD ZZ O 82271320 B-AWARD ZZ O Scientific B-ORG Research I-ORG and I-ORG Innovation I-ORG Program I-ORG of I-ORG Shanghai I-ORG Education I-ORG Commission I-ORG 2019-01-07-00-02-E00064 O GYY O Shanghai B-ORG Rising I-ORG Star I-ORG 21QA1405200 O YT O The O analysis O of O growth O and O biochemical O parameters O was O supported O by O the O Tomsk B-ORG State I-ORG University I-ORG Development I-ORG program I-ORG Priority-2030 O project O no. O 2.1.2.22 B-AWARD The O analysis O of O the O elemental O composition O of O potato O plants O and O expression O of O proline O genes O was O supported O by O the O Russian B-ORG Science I-ORG Foundation I-ORG project O no. O 23-44-10019 B-AWARD The O analysis O of O primary O photosynthetic O processes O was O supported O by O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Higher I-ORG Education I-ORG of I-ORG the I-ORG Russian I-ORG Federation I-ORG project O No. O 122042700044-6 B-AWARD This O research O was O funded O by O Russian B-ORG Science I-ORG Foundation I-ORG grant O number O 17-74-20049 B-AWARD Russian B-ORG Foundation I-ORG for I-ORG Basic I-ORG Research I-ORG grant O number O 19-04-01173 B-AWARD and O Academy B-ORG of I-ORG Finland I-ORG grant O number O 315487 B-AWARD Manish O Saggar O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health I-ORG http://dx.doi.org/10.13039/100000025 O Award O ID: O R00 B-AWARD MH104605 O Caleb O Geniesse O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG http://dx.doi.org/10.13039/100000057 O Award O ID: O T32 B-AWARD GM008294 O Manish O Saggar O National B-ORG Institutes I-ORG of I-ORG Health I-ORG http://dx.doi.org/10.13039/100000002 O Award O ID: O DP2 B-AWARD MH119735 I-AWARD This O work O was O supported O by O the O Institute B-ORG for I-ORG Basic I-ORG Science I-ORG IBS-R011-D1 O This O work O was O partially O supported O by O the O Korea B-ORG Evaluation I-ORG Institute I-ORG of I-ORG Industrial I-ORG Technology I-ORG 20004627 O and O the O INNOPOLIS B-ORG Foundation I-ORG 2019-DD-SB-0602 O This O work O was O supported O by O the O French B-ORG National I-ORG Research I-ORG Agency I-ORG ANR-18-CE11-0015 O and O the O European B-ORG Union’s I-ORG Horizon I-ORG 2020 I-ORG Framework I-ORG Program I-ORG for I-ORG Research I-ORG and I-ORG Innovation I-ORG under O the O Specific O Grant O Agreement O No. O 785907 O and O Human O Brain O Project O SGA2 O G.P O received O support O from O the O Ecole B-ORG Doctorale I-ORG des I-ORG Sciences I-ORG Chimiques I-ORG ED-222 O This O study O is O supported O in O part O by O Taiwan B-ORG Ministry I-ORG of I-ORG Health I-ORG and I-ORG Welfare I-ORG Clinical I-ORG Trial I-ORG and I-ORG Research I-ORG Center I-ORG of I-ORG Excellence I-ORG MOHW107-TDU-B-212-123004 O China B-ORG Medical I-ORG University I-ORG Hospital I-ORG Academia I-ORG Sinica I-ORG Taiwan I-ORG Biobank I-ORG Stroke I-ORG Biosignature I-ORG Project I-ORG BM10701010021 O NRPB B-ORG Stroke I-ORG Clinical I-ORG Trial I-ORG Consortium I-ORG MOST O 106-2321-B-039-005 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51303089 B-AWARD Postdoctoral B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 20110491557 B-AWARD 2012T50597 B-AWARD Postdoctoral B-ORG Innovation I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG No. O 201102039 B-AWARD Changjiang O Scholars O and O Innovative O Research O Team O in O University O IRT_14R30 O Taishan O Scholar O Program O of O Shandong O Province O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81770491 I-AWARD and O No. B-AWARD 82172167 O the O Innovation B-ORG Capacity I-ORG Support I-ORG Plan I-ORG of I-ORG Shaanxi I-ORG Province I-ORG No. O 2020TD-040 O and O the O Natural B-ORG Science I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG Shaanxi I-ORG No. O 2022JQ-899 O The O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31370104 O 31900038 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG China I-ORG 2018JJ2497 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG Central I-ORG South I-ORG University I-ORG 2018zzts119 O 2018zzts392 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Grants O from O the O National O Natural O Science O Foundation O Grants O of O China O 31801147 O the O Shanghai B-ORG Sailing I-ORG Program I-ORG 18YF1410800 O the O startup O fund O for O young O teachers O of O Shanghai B-ORG Jiao I-ORG Tong I-ORG University I-ORG 17X100040083 O the O grants O from O the O Key O Research O Area O Grant O 2016YFA0501703 O of O the O Ministry O of O Science O and O Technology O of O China O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Contract O no. O 61832019 B-AWARD 61503244 O the O State O Key O Lab O of O Microbial O Metabolism O and O Joint O Research O Funds O for O Medical O and O Engineering O and O Scientific O Research O at O Shanghai O Jiao O Tong O University O YG2017ZD14 O The O computations O were O partially O performed O at O the O Center O for O High O Performance O Computing O Shanghai O Jiao O Tong O University O This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG of I-ORG China I-ORG 81570853 O 81770630 B-AWARD Science B-ORG Technology I-ORG Department I-ORG of I-ORG Zhejiang I-ORG Province I-ORG China I-ORG 2018C03021 O Provinces B-ORG and I-ORG Ministries I-ORG Co-Contribution I-ORG of I-ORG Zhejiang I-ORG China I-ORG No.wkj-zj-1706 O and O Key B-ORG projects I-ORG of I-ORG Wenzhou I-ORG science I-ORG and I-ORG technology I-ORG bureau I-ORG 2018ZY008 O This O work O was O supported O by O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG nos O XDB15030302 B-AWARD and O XDB15030202 B-AWARD the O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG no. O 2014CB441000 B-AWARD and O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG President’s I-ORG International I-ORG Fellowship I-ORG Initiative I-ORG no. O 2015PB054 B-AWARD The O current O study O was O supported O by O grants O from O the B-ORG second I-ORG affiliated I-ORG hospital I-ORG of I-ORG Soochow I-ORG university I-ORG pre-research I-ORG project I-ORG SDFEYGJ1609 O the B-ORG second I-ORG affiliated I-ORG hospital I-ORG of I-ORG Soochow I-ORG university I-ORG clinical I-ORG discipline I-ORG group I-ORG project I-ORG funding I-ORG XKQ O 2015008 O the O international B-ORG team I-ORG of I-ORG gastrointestinal I-ORG tumor I-ORG project I-ORG funding I-ORG SZYJTD201804 O and O the B-ORG project I-ORG from I-ORG national I-ORG key I-ORG laboratory I-ORG of I-ORG radiation I-ORG medicine I-ORG GZK1201820 O The O funder O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O supported O by O the O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG grant O number O L172021 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 51875033 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG grant O number O 2019YJS164 B-AWARD This O research O was O supported O by O a O grant O from O State B-ORG Tobacco I-ORG Monopoly I-ORG Bureau I-ORG 110101601024(LS-04 O 110201901041(LS-04 O Jiangxi B-ORG Tobacco I-ORG Research I-ORG Institute I-ORG 2017.01.002 O Sichuan B-ORG Tobacco I-ORG Company I-ORG SCYC201804 O Baoshan B-ORG Company I-ORG of I-ORG Yunnan I-ORG Tobacco I-ORG Company I-ORG 2018530000241014 O All O the O funding O was O awarded O to O Jinguang O Yang O who O also O conceived O the O project O and O designed O the O experiments O The O funders O have O no O role O in O conducting O this O research O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 21728701 B-AWARD Ministry B-ORG of I-ORG Education I-ORG postdoctoral I-ORG fund I-ORG 2015M572044 B-AWARD and O Shandong B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Project I-ORG GG201709260070 B-AWARD to O WL. O This O study O was O also O supported O by O the O Shenyang B-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG Project I-ORG F15-199-1-44 B-AWARD to O WQ. O This O work O is O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81802740 B-AWARD to O JS O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Chongqing I-ORG City O No. O cstc2018jcyjAX0741 B-AWARD to O JS O Cancer B-ORG Prevention I-ORG Research I-ORG Institute I-ORG of I-ORG Texas I-ORG RP160268 O to O BPC O and O National B-ORG Institutes I-ORG of I-ORG Health I-ORG CA233594 O to O BPC O This O work O was O sponsored O by O Chinese B-ORG National I-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2014AA093501 O National B-ORG Special I-ORG Fund I-ORG for I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Bioreactor I-ORG 2060204 O and O Shanghai B-ORG Pujiang I-ORG Program I-ORG 15PJ1401600 O This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81772428 O Special B-ORG Program I-ORG of I-ORG Guangdong I-ORG Frontier I-ORG and I-ORG Key I-ORG Technological I-ORG Innovation I-ORG 2015B010125006 O and O “Clinical B-ORG Research I-ORG Initiative” I-ORG of I-ORG Southern I-ORG Medical I-ORG University I-ORG LC2016ZD032 O This O work O was O supported O by O grants O from O the B-ORG Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG Grant O Number O LZ17H050001 B-AWARD LY16H050005 B-AWARD Y18H050024 B-AWARD the B-ORG Project I-ORG of I-ORG Province I-ORG and I-ORG the I-ORG Ministry I-ORG Grant O Number O WKJ-ZJ-1915 B-AWARD the B-ORG Project I-ORG of I-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Chinese I-ORG Medicine I-ORG Grant O Number O 2017ZA010 B-AWARD 2016ZQ007 B-AWARD The O funders O had O no O role O in O study O design O collection O analysis O interpretation O of O data O writing O the O report O nor O in O the O decision O to O submit O the O report O for O publication O This O work O is O supported O in O part O by O the O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81873471 O 81170110 B-AWARD to O XQ O National B-ORG Key I-ORG R&D I-ORG Plan I-ORG 2016YFA0101100 O to O ND O National O Key O R&D O Plan O 2018YFA0108700 O to O XQ) O and O California B-ORG Institute I-ORG for I-ORG Regenerative I-ORG Medicine I-ORG a O clinical O fellow’s O training O grant O TG2-01164 B-AWARD to O XQ O The O study O was O registered O with O the O US O National O Institutes O of O Health O Clinical O Trials O Register O NCT02536027 O The O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81500066 O the B-ORG Foundation I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG Hunan I-ORG Province I-ORG B2016200 O and O the B-ORG Foundation I-ORG of I-ORG Outstand I-ORG Young I-ORG of I-ORG the I-ORG First I-ORG Peoples’ I-ORG Hospital I-ORG of I-ORG Chenzhou I-ORG N2015-003 O Czech B-ORG Science I-ORG Foundation I-ORG 17-21122S O ELIXIR B-ORG CZ I-ORG Research I-ORG Infrastructure I-ORG Project I-ORG MEYS O LM2015047 O ERDF/ESF B-ORG Project I-ORG “Nanotechnologies I-ORG for I-ORG Future” I-ORG project O CZ.02.1.01/0.0/0.0/16_019/0000754 B-AWARD to O K.B O Palacký B-ORG University I-ORG Olomouc I-ORG IGA_PrF_2019_031 O to O M.Š O and O M.M O Funding O for O the O open O access O charge O Czech O Science O Foundation O 17-21122S O The O part O of O the O work O associated O with O the O analysis O of O underreplication O in O Plato O Atlantis O FISH O localization O of O heterochromatin O probes O and O immunolocalization O of O heterochromatin O proteins O was O funded O by O Russian B-ORG Science I-ORG Foundation I-ORG grant O No. O 19-14-00051 B-AWARD The O part O of O the O work O related O to O the O study O of O replication O was O funded O by O Fundamental O Scientific O Research O Program O on O the O project O 0310-2019-003 O The O super-resolution O microscopy O was O carried O out O with O the O support O of O a O joint O Russian–German O grant O a O grant O from O the O Russian B-ORG Foundation I-ORG for I-ORG Basic I-ORG Research I-ORG No. O 20-54-12016 B-AWARD for O replication O analysis O and O Deutsche B-ORG Forschungsgemeinschaft I-ORG Schu762/12-1 B-AWARD for O super-resolution O microscopy O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 11972334 B-AWARD and O 12272367 B-AWARD the O Key B-ORG R I-ORG I-ORG D I-ORG Plan I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province O grant O number O 2021C01099 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Provincial I-ORG Universities I-ORG of I-ORG Zhejiang O grant O number O 2020YW06 B-AWARD 2020YW19 B-AWARD and O 2021YW81 B-AWARD the O Zhejiang B-ORG Students’ I-ORG Technology I-ORG and I-ORG Innovation I-ORG Program O grant O number O 2023R409A042 B-AWARD This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Number O 81870064 B-AWARD “Gaoyuan” B-ORG project I-ORG of I-ORG Pudong I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG Grant O Number O PWYgy2018-06 B-AWARD National B-ORG Key I-ORG R&D I-ORG Program I-ORG Grant O Number O 2018YFC1313700 B-AWARD from O Qiang O Li O and O the O Research B-ORG Foundation I-ORG of I-ORG Shanghai I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG Grant O Number O 18140904100 B-AWARD from O Shengyun O Wang O This O study O was O financed O by O the O Swiss B-ORG National I-ORG Science I-ORG Foundation I-ORG grant O 32003B_141201 B-AWARD the O Hartmann B-ORG Müller I-ORG Foundation I-ORG grant O 1912 B-AWARD the O Olga O Mayenfisch O Foundation O and O Fondation B-ORG Botnar I-ORG grant O 6066 B-AWARD This O work O was O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG LY17H190001 O grant O to O DJY,http://www.zjnsf.gov.cn O Health B-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2015ZDA025 O grant O to O DJY,http://www.zjwjw.gov.cn O and O Health B-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG Hangzhou I-ORG Manicipality I-ORG grant O 2018ZD001 O to O DJY,http://wsjsw.hangzhou.gov.cn O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O is O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017A030310630 O Guangdong B-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG 2017A070715012 O and O Guangdong B-ORG education I-ORG department I-ORG project I-ORG 2017GCZX003 O 2017KTSCX115 O The O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG nos O 51603029 B-AWARD and O 51773028 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017M623001 O and O the O National B-ORG Postdoctoral I-ORG Program I-ORG for I-ORG Innovative I-ORG Talents I-ORG BX201700044 O In O the O framework O of O Spanish O National O R+D+i O Plan O the O current O study O has O been O co-funded O by O the O Spanish B-ORG Ministry I-ORG of I-ORG Economy I-ORG and I-ORG Competitiveness I-ORG with O the O reference O DEP2012-39828 B-AWARD and O DEP2015-70356 B-AWARD This O study O has O been O also O co-funded O by O the O Government B-ORG of I-ORG Extremadura I-ORG and I-ORG European I-ORG Union I-ORG Regional I-ORG Development I-ORG Funds I-ORG FEDER O a O way O of O making O Europe O ref O GR10127 B-AWARD The O author O DCM O is O supported O by O a O grant O from O the O Spanish B-ORG Ministry I-ORG of I-ORG Education I-ORG Culture I-ORG and I-ORG Sport I-ORG FPU14/01283 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O Research B-ORG and I-ORG Development I-ORG Corporation I-ORG of I-ORG Newfoundland I-ORG and I-ORG Labrador O now O InnovateNL O RDC O Ignite O grant O grant O number O 5404-1815-101 B-AWARD Natural B-ORG Sciences I-ORG and I-ORG Engineering I-ORG Research I-ORG Council I-ORG of I-ORG Canada I-ORG NSERC O grant O number O RGPIN-2016-04464 B-AWARD and O Atlantic B-ORG Canada I-ORG Opportunities I-ORG Agency I-ORG Leverage O grant O with O split O funding O support O from O the O ACOA O and O RDC O grant O number O 206869 B-AWARD The O Article O Processing O Charges O APC O was O funded O by O Memorial O University O Libraries O Grenfell O Newfoundland O Canada O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81470935 O 81370805 I-AWARD 81670645 I-AWARD 81602236 O the O Chenguang B-ORG Program I-ORG of I-ORG Wuhan I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG 2015070404010199 O 2015071704021644 O and O the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 863 I-ORG 2014AA020607 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Funding O for O the O study O design O data O collection O and O preliminary O analyses O was O provided O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 31772654 O and O Beijing B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG Z181100009618031 O Funding O for O the O final O analyses O interpretation O of O the O data O and O writing O of O the O manuscript O was O provided O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0502402 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 61505018 B-AWARD Technology B-ORG Project I-ORG from I-ORG Chongqing I-ORG Education I-ORG Committee I-ORG Grant O No. O KJ1401113 B-AWARD and O Chongqing B-ORG University I-ORG of I-ORG Arts I-ORG and I-ORG Science I-ORG Grant O No. O R2012CJ18 B-AWARD This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81274089 B-AWARD No. O 81473361 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. O LZ13H280001 B-AWARD LY12H280004 B-AWARD and O the O Traditional B-ORG Chinese I-ORG Medicine I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2016ZA130 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81700553 B-AWARD Stem B-ORG Cell I-ORG and I-ORG Translational I-ORG Research I-ORG the I-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFA0101001 B-AWARD and O the O Postdoctoral B-ORG Research I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 2017M183789 B-AWARD This O work O was O supported O by O the O International B-ORG Science I-ORG and I-ORG Technology I-ORG Cooperation I-ORG Program I-ORG of I-ORG China I-ORG National I-ORG No. O 2015DFA31130 B-AWARD the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 I-ORG Program I-ORG No. O 2012CB518406 B-AWARD and O the O Natural B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81173233 B-AWARD 81202683 B-AWARD This O study O was O supported O by O a O Grant O from O the O International B-ORG Initiative I-ORG for I-ORG Impact I-ORG Evaluation I-ORG 3IE O O TW2.2.06 B-AWARD supplement O Kelvin O Principal O Investigator O Elizabeth O Kelvin O was O also O supported O by O the O Einstein-Rockefeller-CUNY O Center O for O AIDS O Research O P30-AI124414 O which O is O supported O by O the O following O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH O Co-Funding O and O Participating O Institutes O and O Centers O NIAID O NCI O NICHD O NHBL O NIDA O NIMH O NIA O FIC O and O OAR O Support O for O Joanne O Mantell O also O came O from O a O center O grant O from O the O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health I-ORG NIMH O to O the O HIV O Center O for O Clinical O and O Behavioral O Studies O at O the O New O York O State O Psychiatric O Institute O and O Columbia O University O P30-MH43520 O Principal O Investigator O Robert O H. O Remien O Ph.D O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 22171061 O and O 21771046 B-AWARD the B-ORG 2020 I-ORG Central I-ORG Government’s I-ORG Plan I-ORG to I-ORG Support I-ORG the I-ORG Talent I-ORG Training I-ORG Project I-ORG of I-ORG the I-ORG Reform I-ORG and I-ORG Development I-ORG Fund I-ORG of I-ORG Local I-ORG Universities I-ORG 2020GSP03 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Heilong I-ORG jiang I-ORG Province I-ORG of I-ORG China I-ORG ZD2021B002 O the B-ORG Master’s I-ORG Degree I-ORG Candidate I-ORG Innovation I-ORG Project I-ORG of I-ORG Harbin I-ORG Normal I-ORG University I-ORG Grant O HSDSSCX2022-112 B-AWARD This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51902279 O Henan B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Project I-ORG 222102230024 O and O the B-ORG Key I-ORG Youth I-ORG Scholar I-ORG Funding I-ORG Project I-ORG of I-ORG Henan I-ORG Province I-ORG of I-ORG China I-ORG 2021GGJS097 O The O design O of O the O study O and O collection O of O data O were O supported O by O the O National B-ORG Key I-ORG Technology I-ORG R&D I-ORG Program I-ORG 2015BAD03B03 O the O collection O analysis O and O interpretation O of O data O were O supported O by O the B-ORG earmarked I-ORG fund I-ORG for I-ORG the I-ORG modern I-ORG agro-industry I-ORG technology I-ORG research I-ORG system I-ORG CARS-41 O and O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG ASTIP-IAS04 O ASTIP-IAS-TS-15 B-AWARD the O interpretation O of O data O and O writing O the O manuscript O were O supported O by O the O National B-ORG Nonprofit I-ORG Institute I-ORG Research I-ORG Grant I-ORG 2017ywf-zd-2 O This O work O was O supported O by O NIH O grants O from O the O National B-ORG Institute I-ORG of I-ORG Neurological I-ORG Disorders I-ORG and I-ORG Stroke I-ORG R01NS024760 O the O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health I-ORG R01MH057414 O and O R01MH101209 B-AWARD and O by O Center B-ORG of I-ORG Excellence I-ORG for I-ORG Learning I-ORG in I-ORG Education I-ORG Science I-ORG and I-ORG Technology O a O National O Science O Foundation O Science O of O Learning O Center O grant O number O NSF B-AWARD SBE-0354378 O MÁG-C O is O the O recipient O of O a O 2014 O National B-ORG Alliance I-ORG for I-ORG Research I-ORG on I-ORG Schizophrenia I-ORG and I-ORG Depression I-ORG NARSAD O Young O Investigator O Grant O from O the O Brain O and O Behavior O Research O Foundation O grant O number O 22777 B-AWARD P&S O Fund O Investigator O This O research O was O funded O by O the O National B-ORG Social I-ORG Science I-ORG Foundation I-ORG Youth I-ORG Project I-ORG Grant O Number O 22CGL027 B-AWARD Guangdong B-ORG Philosophy I-ORG and I-ORG Social I-ORG Sciences I-ORG Planning I-ORG Youth I-ORG Project I-ORG Grant O Number O GD22YGL19 B-AWARD the O General B-ORG Project I-ORG of I-ORG Humanities I-ORG and I-ORG Social I-ORG Science I-ORG Research I-ORG in I-ORG Colleges I-ORG and I-ORG Universities I-ORG of I-ORG Jiangxi I-ORG Province I-ORG Grant O Number O JJ21227 B-AWARD Science B-ORG and I-ORG Technology I-ORG Research I-ORG Project I-ORG of I-ORG Jiangxi I-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG Grant O Number O GJJ210461 B-AWARD and O the O General B-ORG programs I-ORG of I-ORG humanities I-ORG and I-ORG social I-ORG sciences I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG Grant O Number O 20YJAZH113 B-AWARD This O project O was O supported O by O funding O from O the O Department B-ORG of I-ORG State I-ORG Health I-ORG Services O contract O HHS000961900001 B-AWARD to O L.R.R O through O the O US B-ORG Centers I-ORG for I-ORG Disease I-ORG Control I-ORG and I-ORG Prevention I-ORG National I-ORG and I-ORG State I-ORG Tobacco I-ORG Control I-ORG Program I-ORG grant O NU58DP006805 B-AWARD Additionally O work O on O the O manuscript O and O revision O process O was O supported O by O the O National B-ORG Institute I-ORG on I-ORG Drug I-ORG Abuse I-ORG NIDA I-ORG of I-ORG the I-ORG National I-ORG Institutes I-ORG of I-ORG Health I-ORG NIH O award O R25DA054015 B-AWARD to O L.R.R O as O MPI O on O which O M.B O was O a O scholar O and O on O which O T.A.C O and O A.R O were O supported O and O through O a O NOSI O award O NOT-MD-22-001 O funded O by O the O NIDA O of O the O NIH O through O the O National B-ORG Institute I-ORG on I-ORG Minority I-ORG Health I-ORG and I-ORG Health I-ORG Disparities I-ORG award O U54MD015946-03S1 B-AWARD PI: O Dr. O Ezemenari O Obasi O to O M.B O and O I.M.L O as O MPIs O of O the O science O and O to O L.R.R O as O Co-I O Support O on O the O revision O process O was O additionally O supported O by O the O Cancer B-ORG Prevention I-ORG and I-ORG Research I-ORG Institute I-ORG of I-ORG Texas O award O PP230002 B-AWARD to O L.R.R O and O M.B O as O MPIs O Conclusions O drawn O in O this O work O are O solely O the O responsibility O of O the O authors O and O do O not O necessarily O represent O the O official O views O of O the O sponsoring O organizations O This O work O was O supported O by O National B-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81472424 B-AWARD National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFC1303100 B-AWARD Youth B-ORG Talent I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG Health I-ORG System I-ORG No. O XYQ2011054 B-AWARD Shanghai B-ORG Medical I-ORG Center I-ORG of I-ORG Key I-ORG Programs I-ORG for I-ORG Female I-ORG Reproductive I-ORG Diseases I-ORG No. O 2017ZZ01016 B-AWARD This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81170467 O and O 81270569 B-AWARD Major B-ORG Project I-ORG of I-ORG PLA I-ORG Medical I-ORG S&T I-ORG foundation I-ORG AWS11C004 O and O Medical B-ORG Science I-ORG Research I-ORG Foundation I-ORG of I-ORG Chongqing I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Committee I-ORG 2015MSXM224 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O paper O was O jointly O supported O by O the B-ORG Philosophy I-ORG and I-ORG Social I-ORG Sciences I-ORG Projects I-ORG of I-ORG Zhoushan I-ORG Grant O No. O ZXSK2022046 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 42001235 B-AWARD and O the B-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Program I-ORG of I-ORG Zhoushan I-ORG Grant O No. O 2021C21022 B-AWARD The O study O was O funded O by O 985 B-ORG Peking I-ORG University I-ORG and I-ORG Clinical I-ORG Hospital I-ORG Cooperation I-ORG Project I-ORG 2013-1-06 O Clinical B-ORG Research I-ORG Special I-ORG Fund I-ORG of I-ORG Wu I-ORG Jieping I-ORG Medical I-ORG Foundation I-ORG 320.6750.17091 O and O Technology B-ORG Innovation I-ORG Talents I-ORG Special I-ORG Fund I-ORG of I-ORG Harbin I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG 2016RAXYJ089 O This O study O is O supported O by O a O key B-ORG laboratory I-ORG grant I-ORG from I-ORG Hunan I-ORG province I-ORG 2016TP1006 O a O Science B-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG Hunan I-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG 2018SK1030 O and O a O grant O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61702555 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China O grant O number O 2021YFC2300100 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 82103963 B-AWARD Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation O grant O number O 2020A1515110455 B-AWARD Shenzhen B-ORG Science I-ORG and I-ORG technology I-ORG program O grant O number O KQTD20180411143323605 B-AWARD RCBS20210706092345029 B-AWARD and O San-Ming B-ORG Project I-ORG of I-ORG Medicine I-ORG in I-ORG Nanshan I-ORG District I-ORG Shenzhen O grant O number O SZSM202103008 B-AWARD The O study O was O financially O supported O by O the O National B-ORG Research I-ORG Foundation I-ORG NRF O N00591 O 89337 B-AWARD NRF O Thuthuka O N00733 O AOX981 B-AWARD NRF O Incentive O N00375 O Cancer B-ORG Association I-ORG of I-ORG South I-ORG Africa I-ORG CANSA O AOW228 O CANSA O UP O AOV741 O the O Research O Committee O School O of O Medicine O of O the O University O of O Pretoria O RESCOM O AOR984 O the O Struwig-Germeshuysen O Trust O AON074 O the O Research O Development O Program O from O the O University O of O Pretoria O AOV840 O and O the O Medical B-ORG Research I-ORG Council I-ORG AOW110 O This O work O was O supported O by O General B-ORG project I-ORG of I-ORG national I-ORG natural I-ORG science I-ORG foundation I-ORG of I-ORG China I-ORG Grant O No. I-AWARD 81871577 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province O China O Grant O No. I-AWARD 2018JJ3844 O the O Scientific B-ORG Research I-ORG Project I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG Hunan I-ORG Province O China O Grant O No. I-AWARD B2019188 O the O Young B-ORG Science I-ORG Foundation I-ORG of I-ORG Xiangya I-ORG Hospital I-ORG Central I-ORG South I-ORG University I-ORG Grant O No. I-AWARD 2017Q07 O and O the O Postdoctoral B-ORG Research I-ORG Program I-ORG of I-ORG Xiangya I-ORG Hospital I-ORG Central I-ORG South I-ORG University I-ORG Grant O No. I-AWARD 223551 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 21602017 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grant O No. O BK20160405 B-AWARD the O University B-ORG Science I-ORG Research I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG 16KJB150001 O and O the O Research O Start-up O Fund O of O Changshu O Institute O of O Technology O No. O XZ1508 B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81273228 B-AWARD 81373228 B-AWARD and O grants O from O the O Outstanding B-ORG Talent I-ORG Project I-ORG of I-ORG Henan I-ORG Province I-ORG 134100510015 O and O Zhengzhou B-ORG University I-ORG 1421311081 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 22066017 B-AWARD and O 21667019 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Jiangxi I-ORG Province I-ORG 20181ACG70025 O and O the O Key B-ORG Project I-ORG of I-ORG the I-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG of I-ORG Jiangxi I-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG No. O GJJ191044 B-AWARD This O work O was O also O supported O by O Shanghai B-ORG Summit I-ORG Discipline I-ORG in I-ORG Design I-ORG SJGFXK-2019-001 O and O Jiangxi B-ORG Province’s I-ORG “double I-ORG thousand I-ORG plan” I-ORG project O 2020009410085 O This O study O was O supported O by O the O Beijing B-ORG Science I-ORG and I-ORG Technology I-ORG Committee I-ORG z131107002213047 O to O Li O Chen O and O the O Capital B-ORG Health I-ORG Research I-ORG and I-ORG Development I-ORG of I-ORG Special I-ORG Funding I-ORG 2011-2002-01 O and O the B-ORG achievement I-ORG promotion I-ORG project I-ORG from I-ORG Beijing I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG TG-2015-018 O to O Xiaofeng O Huang O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51808187 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20170879 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2019B13514 O the O Jiangsu B-ORG Planned I-ORG Projects I-ORG for I-ORG Postdoctoral I-ORG Research I-ORG Funds I-ORG 1701086B O the O Fund O of O Environmental O Protection O Science O Research O Courses O in O Jiangsu O Province O 2019004 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2019YFC0409000 O and O the O Transportation O Technology O Project O of O Jiangsu O Province O 2019Y30 O This O work O was O supported O by O the O Zhejiang B-ORG Police I-ORG College I-ORG 2022 O university-level O scientific O research O project O 2022QNY001 O Key B-ORG research I-ORG and I-ORG development I-ORG project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2021C03135 O and O Ningbo B-ORG Major I-ORG Special I-ORG Funding I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG 2025 I-ORG 2020Z010 O This O work O was O supported O by O grants O from O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG 2020J01537 O Modern B-ORG Agricultural I-ORG Technology I-ORG System I-ORG Program I-ORG of I-ORG Fujian I-ORG Province I-ORG 2019-144 O and O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Fuzhou I-ORG City I-ORG 2021-N-129 O The O research O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31801951 O 31672483 I-AWARD 31861143013 O the O Young B-ORG Talents I-ORG Academic I-ORG Innovation I-ORG Project I-ORG of I-ORG Hainan I-ORG Association I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG QCXM201715 O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Hainan I-ORG ZDYF2018048 O the O Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG for I-ORG CATAS I-ORG 1630032018004 O and O the O Modern B-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG CARS-34 O The O authors O declare O that O none O of O the O funding O bodies O have O any O role O in O the O design O of O the O study O or O collection O analysis O and O interpretation O of O data O as O well O as O in O writing O the O manuscript O This O work O is O financially O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 51671106 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grants O No. O BK20171424 B-AWARD National O Defense O Basic O Scientific O Research O Program O of O China O Grant O No. O JCKY08414C020 B-AWARD State B-ORG Key I-ORG Lab I-ORG of I-ORG Advanced I-ORG Metals I-ORG and I-ORG Materials I-ORG Grants O No. O 2018-ZD04 B-AWARD and O State O Key O Laboratory O of O Metal O Material O for O Marine O Equipment O and O Application O Grant O No. O HG-SKL(2018)06 B-AWARD This O study O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFA0902200 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51561145015 O and O the O Doctorate B-ORG Fellowship I-ORG Foundation I-ORG of I-ORG Nanjing I-ORG Forestry I-ORG University I-ORG 163030752 O This O research O was O funded O by O the O Science B-ORG and I-ORG Technology I-ORG Research I-ORG Project I-ORG of I-ORG the I-ORG Education I-ORG Department I-ORG of I-ORG Hubei I-ORG Province I-ORG B2021084 O the O Open B-ORG Fund I-ORG of I-ORG Key I-ORG Laboratory I-ORG of I-ORG Road I-ORG Structure I-ORG and I-ORG Material I-ORG of I-ORG Ministry I-ORG of I-ORG Transport I-ORG Changsha O University O of O Science O and O Technology O kfj220304 O the O Science B-ORG Foundation I-ORG of I-ORG the I-ORG Wuhan I-ORG Institute I-ORG of I-ORG Technology I-ORG K201932 O and O the O Postgraduate B-ORG Education I-ORG Innovation I-ORG Fund I-ORG of I-ORG Wuhan I-ORG Institute I-ORG of I-ORG Technology I-ORG CX2021117 O This O project O has O been O funded O by O National O Natural O Sciene O Foundation O of O China O Grant O No. O 81673193 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No.81302424 O Guangdong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O No.2015A030313175 O Specialized B-ORG Research I-ORG Fund I-ORG for I-ORG the I-ORG Doctoral I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG of I-ORG China I-ORG Grant O No.20130171120056 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG in I-ORG SYSU I-ORG Grant O No. O 15ykpy09 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O No O 7171001 B-AWARD to O ZL, O Grant O No O 7182029 B-AWARD to O CZ O Beijing B-ORG Municipal I-ORG Science I-ORG I-ORG Technology I-ORG Commission I-ORG Grant O No O Z171100001017136 B-AWARD to O ZL O The O Charity B-ORG Project I-ORG of I-ORG the I-ORG National I-ORG Ministry I-ORG of I-ORG Health I-ORG Grant O No O 201202014 B-AWARD to O YK O Natural O Science O Foundation O of O China O Grant O No O 81621063 O to O YK, O Grant O No O 81972880 O to O ZL O Beijing B-ORG Hospitals I-ORG Authority I-ORG Youth I-ORG Programme I-ORG Grant O No O QMS20191108 B-AWARD to O CZ O Funding O was O provided O by O Wellcome B-ORG Trust I-ORG Grant O No. O 203132 B-AWARD State B-ORG Government I-ORG of I-ORG Victoria O Operational B-AWARD Infrastructure I-AWARD Support I-AWARD Program O Department B-ORG of I-ORG Education I-ORG and I-ORG Training I-ORG and O Australian B-AWARD Government I-AWARD Research I-AWARD Training I-AWARD Program I-AWARD Scholarship I-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 82002325 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG grant O no. O ZR2020QH075 B-AWARD ZR2021MH167 B-AWARD and O ZR2021LZY004 B-AWARD and O the O Municipal B-ORG Innovation I-ORG Plan I-ORG of I-ORG Clinical I-ORG Medical I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Jinan I-ORG grant O no. O 202134043 B-AWARD This O research O was O funded O by O Hass B-ORG Avocado I-ORG Board O 256060 B-AWARD The O data O collection O for O the O Adventist O Health O Study-2 O was O supported O by O grants O from O the O National B-ORG Institutes I-ORG of I-ORG Health O R01CA094594 B-AWARD and O National B-ORG Cancer I-ORG Institute O U01CA152939 B-AWARD This O work O was O funded O by O Czech B-ORG Science I-ORG Foundation I-ORG 15-05180S O by O the O project O CEITEC-Central B-ORG European I-ORG Institute I-ORG of I-ORG Technology I-ORG CZ.1.05/1.100/02.0068 O from O European O Regional O Development O Fund O Internal B-ORG Grant I-ORG Agency I-ORG of I-ORG University I-ORG of I-ORG Veterinary I-ORG and I-ORG Pharmaceutical I-ORG Sciences I-ORG Brno I-ORG 90/2014/FVL O co-financed O from O European B-ORG Social I-ORG Fund I-ORG and I-ORG state I-ORG budget I-ORG of I-ORG the I-ORG Czech I-ORG Republic I-ORG project O OPVK B-AWARD CZ.1.07/2.3.00/20.0300 O and O finally O supported O by O the O Institute B-ORG of I-ORG Vertebrate I-ORG Biology I-ORG Academy I-ORG of I-ORG Sciences I-ORG of I-ORG the I-ORG Czech I-ORG Republic I-ORG RVO O 68081766 O This O work O was O financially O supported O by O the O Shandong B-ORG Provincial I-ORG Modern I-ORG Agriculture I-ORG Industry I-ORG Technology I-ORG System I-ORG no. O SDAIT B-AWARD 1001 O the O National B-ORG Key I-ORG Technology I-ORG Support I-ORG Program I-ORG 2015BAD03B05 O and O the O Funds B-ORG of I-ORG Shandong I-ORG “Double I-ORG Tops” I-ORG Program O No. O SYL2017YSTD12 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG Grant O No. O 17ZR1439300 B-AWARD the O Scientific B-ORG Research I-ORG Program I-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Grant O No. O 201640269 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No.81772955 O Genome O sequencing O assembly O and O annotation O were O conducted O by O the O Novogene B-ORG Bioinformatics I-ORG Institute I-ORG Beijing I-ORG China O mutual O contract O No. O C101SC17090417 B-AWARD This O work O was O supported O through O the O Bagui B-ORG Scholarship I-ORG team I-ORG funding O under O Grant O No. O C33600992001 B-AWARD the O Guangxi O Province O One O Hundred O Talent O program O and O Guangxi O University O to O J.S.S O and O by O funding O from O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG under O Grant O No. O 2015M582481 B-AWARD and O No. O 2016T90822 B-AWARD to O D.D.H O and O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O No. O 31470469 B-AWARD to O K.F.C O This O work O was O supported O by O funds O from O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 30672073 B-AWARD 81072004 B-AWARD and O 81372614 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG Project I-ORG in I-ORG Shanghai I-ORG No.13ZR1432300 O and O the O Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG Research I-ORG Project I-ORG Nos O 19411966300 B-AWARD and O 19140902302 B-AWARD This O work O was O supported O by O grants O from O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG Grant O Nos.LY16H280011 B-AWARD Nos.LY18H290006 O Key B-ORG Research I-ORG Program I-ORG of I-ORG Traditional I-ORG Chinese I-ORG medical I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG of I-ORG Zhejiang I-ORG Province I-ORG Grant O Nos.2016ZZ012 O Medical B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG Grant O Nos.WKJ-ZJ-1728 B-AWARD Nos.2016KYB220 O All O funding O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61703207 O 61973160 O Jiangsu B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG BK20170801 O Aeronautical B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 2018ZC52037 O This O work O was O funded O by O grants O from O the O Hainan B-ORG Province I-ORG Clinical I-ORG Medical I-ORG Center I-ORG QWYH202175 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82160544 O the O Research B-ORG and I-ORG Cultivation I-ORG Fund I-ORG of I-ORG Hainan I-ORG Medical I-ORG University I-ORG HYPY2020015 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hainan I-ORG Province I-ORG 820RC771 O and O the O Key B-ORG R&D I-ORG Projects I-ORG of I-ORG Hainan I-ORG Province I-ORG ZDYF2022SHFZ074 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the B-ORG Special I-ORG Fund I-ORG for I-ORG Forest I-ORG Scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Welfare I-ORG 201404210 O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Non-profit I-ORG Research I-ORG Institution I-ORG CAFYBB2014MA002 O and O the B-ORG Fund I-ORG for I-ORG Cooperation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG and I-ORG Chinese I-ORG Academy I-ORG of I-ORG Forestry I-ORG 2015SY01 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O whole O work O was O supported O by O 973 B-ORG project I-ORG No. O 2013CB733502 B-AWARD National B-ORG Key I-ORG Technology I-ORG Support I-ORG Program I-ORG 2014BAD02B04 O and O CAS B-ORG database I-ORG project I-ORG XXH12504-3-18 O Supported O by O Shanghai B-ORG Municipal I-ORG Natural I-ORG Science I-ORG Foundation I-ORG NO.16ZR1426700 O and O Project B-ORG of I-ORG Shanghai I-ORG Science I-ORG and I-ORG Technology I-ORG NO.17411950207 O and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG NO.1501219166 O This O work O was O funded O by O Wellcome B-ORG Trust O www.wellcome.ac.uk O Grant O number O 053267/Z98F B-AWARD awarded O to O DJW O Medical B-ORG Research I-ORG Council;www.mrc.ac.ukGrant O number O 4050189188 B-AWARD awarded O to O DJW O The O Anthony B-ORG Cerami I-ORG and I-ORG Ann I-ORG Dunne I-ORG Foundation I-ORG for I-ORG World I-ORG Health I-ORG www.acadforworldhealth.org O Donation B-AWARD to O DJW O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O Ministry B-ORG of I-ORG Health I-ORG Czech I-ORG Republic I-ORG grant O number O 16-32696A B-AWARD project O Nr. O LO1611 B-AWARD with O a O financial O support O from O the O MEYS B-ORG under I-ORG the I-ORG NPU I-ORG I I-ORG Programme O the O Ministry B-ORG of I-ORG Health I-ORG Czech I-ORG Republic I-ORG – I-ORG Conceptual I-ORG Development I-ORG of I-ORG Research I-ORG Organization I-ORG 00023001 B-AWARD Institut O klinické O a O experimentální O medicíny O IKEM O Prague O Czech O Republic O – O Institutional O support O and O by O the O Czech B-ORG Science I-ORG Foundation I-ORG project O number O 17-01251S.The B-AWARD funding O source O had O no O role O in: O the O study O design O the O collection O analysis O the O interpretation O of O data O the O writing O of O the O paper O nor O in O the O decision O for O publication O Hans-Sigrist-Stiftung B-ORG Grant O number O 10R00546 B-AWARD awarded O to O Dr. O Marina O A.G O von O Keyserlingk O Genome B-ORG British I-ORG Columbia I-ORG Grant O number O SOC007 B-AWARD awarded O to O Dr O Daniel O M O Weary O and O Wellcome B-ORG Trust I-ORG Grant O number O 203132/Z/16/Z B-AWARD awarded O to O Dr O Adam O Shriver O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O funding O from O the B-ORG International I-ORG Initiative I-ORG for I-ORG Impact I-ORG Evaluation I-ORG 3ie O grant O number O PW2.03.CH.IE B-AWARD URL:http://www.3ieimpact.org(to O RL O the B-ORG UBS I-ORG Optimus I-ORG Foundation O grant O number O 12-6140 B-AWARD URL:https://www.ubs.com/global/en/wealth_management/optimusfoundation.html(to O HZ O and O China B-ORG Medical I-ORG Board O grant O number O 13-158 B-AWARD URL:http://www.chinamedicalboard.org(to O YS O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O in O part O by O grants O from O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province O LY15H300004 B-AWARD Research B-ORG Funding I-ORG of I-ORG Wenzhou I-ORG Medical I-ORG University O QTJ1403A B-AWARD Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Wenzhou O Y20140724 B-AWARD Science O and O Technology O Project O of O Wenzhou O Y20160163 B-AWARD We O acknowledge O funding O from O the O Agence B-ORG Nationale I-ORG de I-ORG la I-ORG Recherche I-ORG Project O 11-JSV7-0013 B-AWARD and O PHC O Maimonide O Campus B-ORG France I-ORG France/Israel O project O 33583WA B-AWARD to O NB. O The O Institut O Jean-Pierre O Bourgin O benefits O from O the O support O of O the O LabEx B-ORG Saclay I-ORG Plant I-ORG Sciences-SPS I-ORG Project O 10-LABX-0040-SPS B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O in O part O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG 5R01HL089315-11 O YJW O the O American B-ORG Heart I-ORG Association I-ORG 18POST33990223 O HW; O 17POST33410497 B-AWARD MJP O the O National B-ORG Science I-ORG Foundation I-ORG GRFP O DGE-1147470 O AMI O and O generous O support O from O Donald O and O Sally O O’Neal O This O study O was O funded O by O the O Special B-ORG Foundation I-ORG of I-ORG Basic I-ORG Science I-ORG and I-ORG Technology I-ORG Resources I-ORG Survey I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG No. O 2017FY101200 B-AWARD the O China B-ORG Short-Term I-ORG Health I-ORG Effects I-ORG of I-ORG Air I-ORG Pollution I-ORG Study I-ORG China O SHEAP O Study O No. O 2016YFC0206500 B-AWARD the O Sichuan B-ORG Provincial I-ORG Medical I-ORG Research I-ORG Youth I-ORG Innovation I-ORG Project I-ORG No. O Q17070 B-AWARD and O the O Sichuan B-ORG Provincial I-ORG Cadre I-ORG Health I-ORG Care I-ORG Research I-ORG Project I-ORG No. O ZH2018-1801 B-AWARD The O work O is O funded O by O theBritish O Heart I-ORG Foundation(grants O number O RG/16/3/32175 B-AWARD PG/15/59/31621 B-AWARD and O PG/16/17/32069 B-AWARD andBritish O Heart I-ORG Foundation I-ORG Centre I-ORG of I-ORG Research I-ORG Excellence I-ORG StudentshipsRE/13/4/30184 O theWellcome/EPSRC O Centre I-ORG for I-ORG Medical I-ORG Engineering(WT O 203148/Z/16/Z O the O Imperial O College O Centre O for O Cardiac O Engineering O and O the O National O Institute O for O Health O Research O Imperial O Biomedical O Research O Centre O This O research O was O financially O supported O by O the O grants O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21808114 O the B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG 2019GSF107044 O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2016CB03 O and O the B-ORG Young I-ORG Doctoral I-ORG Cooperation I-ORG Fund I-ORG Project I-ORG of I-ORG Qilu I-ORG University I-ORG of I-ORG Technology I-ORG Shandong O Academy O of O Sciences O 2017BSHZ007 O J.A.S O is O supported O by O the O Kidney O Research O Fund O and O the O Medical B-ORG Research I-ORG Council I-ORG MR/M012212/1 O S.A.R O is O a O Kidney O Research O UK O Post-Doctoral O Fellow O O.D O is O supported O by O grants O from O the O European O Community’s O Seventh O Framework O Programme O 305608 O EURenOmics O the O Swiss O National O Centre O of O Competence O in O Research O Kidney O Control O of O Homeostasis O NCCR O Kidney.CH O programme O the O Swiss B-ORG National I-ORG Science I-ORG Foundation I-ORG 31003A_169850 O and O the O Rare O Disease O Initiative O Zürich O Radiz O a O clinical O research O priority O program O of O the O University O of O Zürich O Switzerland O E.O O is O supported O by O the O Fonds B-ORG National I-ORG de I-ORG la I-ORG Recherche I-ORG Luxembourg I-ORG 6903109 O and O the O University O Research O Priority O Programme‘Integrative O Human O Physiology O ZIHP’ O of O the O University O of O Zürich O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31672401 O Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG ZR2014CM029 O A B-ORG Project I-ORG of I-ORG Shandong I-ORG Province I-ORG Higher I-ORG Educational I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG China I-ORG J14LF07 O Shandong B-ORG Provincial I-ORG Modern I-ORG Agriculture I-ORG Industry I-ORG Technology I-ORG System I-ORG SDAIT-10 O Funds B-ORG of I-ORG Shandong I-ORG “Double I-ORG Tops” I-ORG Program I-ORG SYL2017YSTD12 O This O work O was O supported O by O 1) O YNH O Scientific B-ORG Research I-ORG Start-up I-ORG Funds I-ORG for I-ORG Openly-recruited I-ORG Doctors I-ORG of I-ORG Gansu I-ORG Agricultural I-ORG University I-ORG Grant O numbers O 2017RCZX-08 B-AWARD 2) O YNH O Special B-ORG Funds I-ORG for I-ORG Discipline I-ORG Construction I-ORG of I-ORG Gansu I-ORG Agricultural I-ORG University I-ORG Grant O number O GAU-XKJS-2018-157 B-AWARD 3) O YXS O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O number O 31960561 B-AWARD 4) O CZL O The B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O number O 2018YFD0200405 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grants O No. O 61931011 O No. O 61872178 B-AWARD No. O 61827801 B-AWARD No. O 61702545 B-AWARD No. O 61702525 B-AWARD and O No. O 61631020 B-AWARD in O part O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 021014380079 B-AWARD and O in O part O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG under O Grant O No. O BK20181251 B-AWARD This O work O is O supported O by O the B-ORG University I-ORG Nature I-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG Anhui I-ORG Province I-ORG grant O number O KJ2017A832 B-AWARD Program B-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG of I-ORG Anhui I-ORG Province I-ORG grant O number O 1704a0802158 B-AWARD and O the B-ORG Natural I-ORG science I-ORG foundation I-ORG project I-ORG of I-ORG Anhui I-ORG Province I-ORG grant O number O 1408085QH174 B-AWARD This O work O was O supported O by O the O R O O D O project O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Government I-ORG of I-ORG the I-ORG People's I-ORG Republic I-ORG of I-ORG Bangladesh I-ORG Grant O No. O 39.012.002.02.01.016.2013-463 B-AWARD TWAS B-ORG Grant O No. O 12-103 B-AWARD RG/BIO/AS_I-UNESCO I-AWARD FR: I-AWARD 3240271353 O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Government I-ORG of I-ORG the I-ORG People’s I-ORG Republic I-ORG of I-ORG Bangladesh I-ORG Grant O No. O 39.009.006.01.00.042.2012-2013/ES-21/558 B-AWARD and O Japan B-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG JSPS I-ORG Kakenhi I-ORG Japan I-ORG Grant O No.24406009 O The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O Beijing B-ORG Tiantan I-ORG Hospital I-ORG Funds I-ORG for I-ORG Young I-ORG Scholars I-ORG project I-ORG #2014-YQN-YS-26 O the O National B-ORG Key I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2013BAI09B03 O 2015BAI12B04 B-AWARD and O the O Beijing B-ORG Talents I-ORG Fund I-ORG 2014000021469G257 O The O study O was O supported O by O grants O from O the O Chief B-ORG Scientist I-ORG Office I-ORG Scottish O Executive O CZG/1/109 B-AWARD O CZG/4/742 B-AWARD NHS B-ORG Grampian I-ORG Endowments I-ORG 08/02 O the O European B-ORG Community's I-ORG Seventh I-ORG Framework I-ORG Programme I-ORG FP7/2007-2013 O under O grant O agreement O no O 212885 B-AWARD and O the O Medical B-ORG Research I-ORG Council O UK O MR/L010011/1 O The O authors O declare O they O have O no O competing O interests O be O it O financial O personal O or O professional O This O work O was O supported O by O the O Cultivating B-ORG Outstanding I-ORG Talents I-ORG Project I-ORG of I-ORG Hebei I-ORG Provincial I-ORG Government I-ORG Fund I-ORG No. O 2019012 B-AWARD Hebei B-ORG public I-ORG health I-ORG committee I-ORG county-level I-ORG public I-ORG hospitals I-ORG suitable I-ORG health I-ORG technology I-ORG promotion I-ORG and I-ORG storage I-ORG project I-ORG No. O 2019024 B-AWARD Hebei B-ORG University I-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Project I-ORG No. O ZD2019139 B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG of I-ORG China I-ORG 81100593 O 81770785 B-AWARD and O Provincial B-ORG key I-ORG research I-ORG and I-ORG development I-ORG plan(2017GSF18154 O to O Jia O Liu O and O was O partially O supported O by O Science B-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Shandong I-ORG Province I-ORG 2015GGH318016 O to O Dongmei O Zheng O This O work O has O been O funded O by O the B-ORG Spanish I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Innovation I-ORG MCIN/AEI/10.13039/501100011033 O and O by O the B-ORG European I-ORG Union’s I-ORG ERDF I-ORG program I-ORG “A I-ORG way I-ORG of I-ORG making I-ORG Europe” O Grant O references O RTI2018-094906-B-C22 B-AWARD and O PID2020-113705RB-C32 B-AWARD Also O it O was O funded O by O the B-ORG European I-ORG Union’s I-ORG Horizon I-ORG 2020 I-ORG Research I-ORG and I-ORG Innovation I-ORG funding I-ORG program O under O Grant O Agreement O No. O 101004761 B-AWARD AIDAInnova O and O by O the B-ORG European I-ORG Synchrotron I-ORG Radiation I-ORG Facility I-ORG ESRF O This O work O was O funded O by O a O British O Council O Newton O Fund O Newton O Fund O Institutional O Links O grant O 275542783 O to O GC O Reilly O and O MA O Puertas-Mejia O M O Silva O and O MA O Puertas-Mejia O are O thankful O to O Colciencias B-ORG Contract O 259-2017 B-AWARD and O Universidad B-ORG de I-ORG Antioquia I-ORG Vicerrectoría O de O Investigación O CODI O proj O 2019-25210 B-AWARD D O Gupta O was O funded O by O the O Newton O Fund O K O Radziun O was O a O visiting O student O to O The O University O of O Sheffield O funded O by O ERASMUS O J O Marshall O was O funded O by O the O Newton O Fund O and O the O Engineering O and O Physical O Sciences O Research O Council O EPSRC O project O MultiSim O Grant O No. O EP/K03877X/1 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 61272388 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG Grant O No. O H2015096 B-AWARD and O the O Science B-ORG I-ORG Technology I-ORG Research I-ORG Project I-ORG of I-ORG the I-ORG Heilongjiang I-ORG Ministry I-ORG of I-ORG Education I-ORG Grant O No. O 12541356 B-AWARD This O work O was O sponsored O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32260737 O Project B-ORG of I-ORG Sanya I-ORG Yazhou I-ORG Bay I-ORG Science I-ORG and I-ORG Technology I-ORG City I-ORG SCKJ-JYRC-2022-93 O SCKJ-JYRC-2022-84 B-AWARD and O Hainan B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 321RC1088 O 321MS091 B-AWARD This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81473315 B-AWARD Public B-ORG Welfare I-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG State I-ORG Administration I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG 201507004-2-1 O and O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG CIFMS O No. O 2016-I2M-3-015 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O project O was O funded O by O the B-ORG Young I-ORG Scholar I-ORG Research I-ORG Grant I-ORG from I-ORG the I-ORG Chinese I-ORG Anesthesiologist I-ORG Association I-ORG grant O number O 220160900008 B-AWARD the B-ORG Young I-ORG Scholar I-ORG Research I-ORG Grant I-ORG from I-ORG Shanghai I-ORG Chilren’s I-ORG Medical I-ORG Center I-ORG grant O number O YJ-SCMC-2017-13 B-AWARD the B-ORG Shanghai I-ORG Committee I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Shanghai O China O grant O number O 16411967500 B-AWARD and O the B-ORG Shanghai I-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Key I-ORG Developing I-ORG Disciplines I-ORG Shanghai O China O grant O number O 015ZB0106 B-AWARD This O work O was O supported O by O the O Global B-ORG Climate I-ORG Change I-ORG and I-ORG Ocean I-ORG Atmosphere I-ORG Interaction I-ORG Research O GASI-01-02-04 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O 41406216 B-AWARD O 41506217 B-AWARD and O the O Scientific B-ORG Research I-ORG Foundation I-ORG of I-ORG TIO I-ORG SOA O 2017009 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China O grant O number O 2017YFD0202000 B-AWARD and I-AWARD 2018YFD0201506 O National O Modern O Agricultural O Citrus O Technology O Systems O of O China O grant O number O CARS-26 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 31701755 B-AWARD Guangdong B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project O Grant O number O 2018B020202009 B-AWARD This O study O was O financially O supported O by O grants O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Funder O X.D O No. O 2020YFC2004105 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Funder O C.L O No. O 62171300 B-AWARD Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Funder O R.C O No. O 7212046 B-AWARD Beijing B-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospitals I-ORG Clinical I-ORG Medicine I-ORG Development I-ORG of I-ORG Special I-ORG Funding I-ORG Support I-ORG Funder O R.C O No. O XML201714 B-AWARD and O Research B-ORG Program I-ORG of I-ORG China I-ORG Disabled I-ORG Persons’ I-ORG Federation I-ORG Funder O X.D O No. O 2202CDPFHS-10 B-AWARD Funding O was O provided O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Xi’an I-ORG Medical I-ORG University I-ORG with O Grant O No. O 16hlxk18 B-AWARD Funding O was O provided O by O Shaanxi B-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG with O Grant O No. O 2016A005 B-AWARD Funding O was O provided O by O Shaanxi B-ORG Planning I-ORG Office I-ORG of I-ORG philosophy I-ORG and I-ORG social I-ORG sciences I-ORG with O Grant O No. O 2017G011 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81971586 O 82071874 B-AWARD 81901712 B-AWARD 821201080105 O 82271981 B-AWARD Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG 2020YFS0050 O 2020YJ0029 O 21ZDYF1967 O 2022YFS0178 B-AWARD Clinical B-ORG Research I-ORG Finding I-ORG of I-ORG Chinese I-ORG Society I-ORG of I-ORG Cardiovascular I-ORG Disease I-ORG CSC I-ORG of I-ORG 2019 I-ORG No. O HFCSC2019B01 O and O the O Fellowship O of O China O postdoctoral O science O foundation O 2021M692290 O This O work O was O supported O by O grants O from O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0500406 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O Nos O 31772736 B-AWARD 31502062 B-AWARD the O Outstanding B-ORG youth I-ORG project I-ORG of I-ORG Natural I-ORG Science I-ORG Foundation I-ORG in I-ORG Hubei I-ORG Province I-ORG 2018CFA070 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Program O No. O 2662018PY032 B-AWARD This O work O was O supported O by O grants O from O Associazione B-ORG Italiana I-ORG per I-ORG la I-ORG Ricerca I-ORG sul I-ORG Cancro I-ORG AIRC O IG B-AWARD 20528 I-AWARD to O M.G.;http://www.airc.it O accessed O on O 15 O December O 2022 O from O the O Ministry B-ORG of I-ORG Education I-ORG and I-ORG Science I-ORG of I-ORG the I-ORG Russian I-ORG Federation I-ORG 14.Z50.31.0005 O to O M.G O from O Fundamental B-ORG Scientific I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG and I-ORG Science I-ORG of I-ORG the I-ORG Russian I-ORG Federation I-ORG project O FWGZ-2021-0017 B-AWARD to O A.V.P O The O funders O had O no O role O in O the O study O design O data O collection O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O current O study O received O funding O from O the O Beijing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG no. O Z181100001718159 B-AWARD Key O Laboratory O of O Trauma O and O Neural O Regeneration O Peking O University O Ministry O of O Education O No. O BMU2019XY007-01 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China O No. O 2016YFC1101604 B-AWARD the B-ORG Ministry I-ORG of I-ORG Education I-ORG Innovation I-ORG Program I-ORG of I-ORG China O No. B-AWARD IRT_16R01 I-AWARD Jun O Liu O was O supported O by O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG No. O XDB26000000 B-AWARD the O International B-ORG Partnership I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG No. O 132311KYSB20190010 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 41572019 B-AWARD Fernando O Abdala O was O supported O by O the O Conicet O of O Argentina O NRF O of O South O Africa O and O a O research O trip O to O China O funded O by O the O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG President’s I-ORG International I-ORG Fellowship I-ORG Initiative I-ORG Grant I-ORG 2016VBB054 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China O grant O number O 2021YFD1300300 B-AWARD the O Innovation B-ORG and I-ORG Entrepreneurship I-ORG Training I-ORG Program I-ORG for I-ORG College I-ORG Students I-ORG in I-ORG Henan I-ORG Province I-ORG of I-ORG China O grant O number O 202210463033 B-AWARD the O start-up B-ORG fund I-ORG project I-ORG for I-ORG high-level I-ORG talent I-ORG scientific I-ORG research I-ORG of I-ORG Henan I-ORG University I-ORG of I-ORG Technology I-ORG of I-ORG China O grant O number O 2021BS072 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 32202722 B-AWARD and O Key B-ORG scientific I-ORG research I-ORG Project I-ORG of I-ORG colleges I-ORG and I-ORG universities I-ORG in I-ORG Henan I-ORG Province I-ORG of I-ORG China O grant O number O 23A230001 B-AWARD The O APC O was O funded O by O the O National O Key O Research O and O Development O Program O of O China O This O work O was O supported O by O grants O from O The B-ORG most I-ORG important I-ORG clinical I-ORG medical I-ORG center I-ORG and I-ORG key I-ORG discipline I-ORG construction I-ORG of I-ORG Shanghai I-ORG 2017ZZ02007 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81600630 O and O 81872352 B-AWARD The B-ORG Foundation I-ORG of I-ORG Shanghai I-ORG Science I-ORG and I-ORG Technology I-ORG Committee I-ORG 16411952000 O Clinical B-ORG Study I-ORG of I-ORG Zhongshan I-ORG Hospital I-ORG 2018ZSLC24 O JianFeng B-ORG project I-ORG of I-ORG Xuhui I-ORG Provincial I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG SHXH201703 O This O research O was O supported O by O The O National B-ORG Natural I-ORG Science I-ORG Fund I-ORG of I-ORG China O grant O number O 72162006 B-AWARD Youth B-ORG Talent I-ORG Development I-ORG Fund I-ORG of I-ORG Guizhou I-ORG Education I-ORG Department I-ORG China O grant O number O KY B-AWARD Zi I-AWARD 2021]128 O the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Guizhou I-ORG Province O grant O number O ZK B-AWARD 2021]196 I-AWARD This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O China O 2018A0303130167 O the B-ORG Guangzhou I-ORG Planned I-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG China I-ORG 201707010279 O 201300000100 I-AWARD and I-AWARD 201704020105 O the B-ORG Guangdong I-ORG Medical I-ORG Science I-ORG and I-ORG Research I-ORG Foundation I-ORG China I-ORG A2018258 O the B-ORG Guangzhou I-ORG General I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG China I-ORG 20181A011011 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O corresponding O author O had O full O access O to O all O the O data O in O the O study O and O had O final O responsibility O for O the O decision O to O submit O for O publication O RL O thanks O funding O support O from O the O Singapore B-ORG Ministry I-ORG of I-ORG Health’s I-ORG National I-ORG Medical I-ORG Research I-ORG Council I-ORG under O its O Centre O Grant O Program O MOH-001001-00 O and O Open B-ORG Funding—Independent I-ORG Research I-ORG Grant I-ORG MOH-000963-00 O This O work O is O partly O funded O by O SNEC B-ORG Ophthalmic I-ORG Technology I-ORG Incubator I-ORG Program I-ORG R1285/91/2015 O This O work O has O been O supported O by O theDélégation O Générale I-ORG pour I-ORG l’Armement(DGA O MSProfileR O project O Grant O no O PDH-2-NBC B-AWARD 2-B-2201 O and O by O the O Regional B-ORG Health I-ORG Agency I-ORG of I-ORG French I-ORG Guiana I-ORG Conventions O n° O FIR/ARS/2014/91 B-AWARD n°FIR/ARS/2015/68 B-AWARD and O Convention O ARS/IPG B-AWARD 2021–2023—26th O November O 2021 O This O work O was O also O partially O supported O by O the O European B-ORG Union I-ORG FEDER I-ORG controle I-ORG Programme I-ORG under O Grant O number O GY0010695 B-AWARD This O work O was O supported O by O grants O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81570363 B-AWARD the O National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFA0201304 B-AWARD and O a B-ORG Project I-ORG Funded I-ORG by I-ORG the I-ORG Priority I-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O No. O KYZZ15_0263 B-AWARD This O study O was O funded O by O The B-ORG Scientific I-ORG and I-ORG Technological I-ORG Research I-ORG Council I-ORG of I-ORG Turkey I-ORG SBAG O 114S999 O and O the O Armed B-ORG Forces I-ORG Health I-ORG Surveillance I-ORG Board I-ORG Global I-ORG Emerging I-ORG Infections I-ORG Surveillance I-ORG and I-ORG Response I-ORG System I-ORG AFHSB-GEIS O USA O FY18 O Award O P0034_18_WR B-AWARD PI: O Y-ML O under O US O Army O subcontract O W911QY-16-C-0160 O to O Hacettepe O University O The O research O was O supported O by O Hacettepe B-ORG University I-ORG Scientific I-ORG Research I-ORG Unit I-ORG 01001601001 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O material O to O be O published O reflects O the O views O of O the O authors O and O should O not O be O construed O to O represent O those O of O the O US O Department O of O the O Army O or O the O US O Department O of O Defense O This O work O was O funded O by O projects O Metabarpark O from O the O Spanish B-ORG National I-ORG Parks I-ORG Autonomous I-ORG Agency I-ORG OAPN O project I-AWARD 1036-2013 O and O ChallenGen B-ORG CTM2013-48163 B-AWARD and O PopComics B-ORG CTM2017-88080 B-AWARD from O the O Spanish O Government O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 11602099 O and O 11925204 O the O China B-ORG Scholarship I-ORG Council I-ORG CSC O File B-AWARD No. I-AWARD 201806185038 O and O the O 111 B-ORG Project I-ORG B14044 O The O APC O was O funded O by O the O National O Natural O Science O Foundation O of O China O 11925204 O This O work O was O sponsored O by O a O grant O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31471548)(Renhai B-AWARD Peng O State O Key O Laboratory O of O Cotton O Biology O Open O Fund O No. O CB2017A06)(Yuling O Liu O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2016YFD0100203)(Renhai O Peng O PhD O Scientific O Research O Fund O of O Anyang O Institute O of O Technology O BSJ2016005)(Yuling O Liu O Key B-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG Higher I-ORG Education I-ORG in I-ORG Henan I-ORG Province I-ORG 18B210001)(Yuling O Liu O Science O and O Technology O Development O Program O of O Henan O Province O 182102110048 O and O Innovation B-ORG Scientists I-ORG and I-ORG Technicians I-ORG Troop I-ORG Construction I-ORG Projects I-ORG of I-ORG Henan I-ORG Province I-ORG 184200510009 O Renhai O Peng O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O UK O Economic B-ORG and I-ORG Social I-ORG Research I-ORG Council I-ORG ESRC O Grant O number O ES/P011020/1 B-AWARD RM O is O supported O by O the O UK O Medical B-ORG Research I-ORG Council I-ORG MRC O Places O and O Health O Programme O Grant O number O MC_UU_12017/10 B-AWARD and O the O Chief B-ORG Scientist I-ORG Office I-ORG CSO O Grant O Number O SPHSU10 B-AWARD The O funders O had O no O role O in O the O design O of O the O study O in O the O collection O analyses O or O interpretation O of O data O in O the O writing O of O the O manuscript O or O in O the O decision O to O publish O the O results O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Project O No. O 51608131 B-AWARD Guangdong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Project O No. O 2021A1515011747 B-AWARD Pearl B-ORG River I-ORG S&T I-ORG Nova I-ORG Program I-ORG of I-ORG Guangzhou I-ORG City I-ORG Project O No. O 201906010064 B-AWARD and O European B-ORG Regional I-ORG Development I-ORG Fund I-ORG Project O No. O 01.2.2-LMT-K-718-03-0010 B-AWARD under O a O grant O agreement O with O the O Research O Council O of O Lithuania O LMTLT O This O work O was O supported O by O the O Beijing B-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospitals I-ORG Incubating I-ORG Program I-ORG PX2016065 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Capital I-ORG Medical I-ORG University I-ORG China I-ORG PYZ2017031 O and O the O Health B-ORG Science I-ORG Promotion I-ORG Project I-ORG of I-ORG Beijing I-ORG 2018-TG-45 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O grants O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0500800 O the O Sichuan-International B-ORG joint I-ORG research I-ORG for I-ORG science I-ORG and I-ORG technology I-ORG 2018HH0098 O China B-ORG Agricultural I-ORG Research I-ORG System I-ORG CARS-42-17 O the B-ORG Program I-ORG Sichuan I-ORG Veterinary I-ORG Medicine I-ORG and I-ORG Drug I-ORG Innovation I-ORG Group I-ORG of I-ORG China I-ORG Agricultural I-ORG Research I-ORG System I-ORG CARS-SVDIP O Integration B-ORG and I-ORG Demonstration I-ORG of I-ORG Key I-ORG Technologies I-ORG for I-ORG Goose I-ORG Industrial I-ORG Chain I-ORG in I-ORG Sichuan I-ORG Province I-ORG 2018NZ0005 O This O work O was O supported O by O grants O of O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 81501065 B-AWARD no.81571147 O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG no. O LY16H090004 B-AWARD Zhejiang B-ORG Provincial I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG no.2016ZA115 O Zhejiang B-ORG Provincial I-ORG Medical I-ORG and I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG no.2015KYA091 O This O work O was O supported O by O the B-ORG National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41390461 O 41501233 O to O Xiaoxu O Jia O http://www.nsfc.gov.cn O the O National O Natural O Science O Foundation O of O China O 41530854 O http://www.nsfc.gov.cn O the B-ORG National I-ORG Key I-ORG Project I-ORG for I-ORG Research I-ORG and I-ORG Development I-ORG 2016YFC0501605 O to O Mingan O Shao O http://www.most.gov.cn O the B-ORG Program I-ORG for I-ORG Bingwei I-ORG Excellent I-ORG Talents I-ORG from I-ORG Institute I-ORG of I-ORG Geographic I-ORG Sciences I-ORG and I-ORG Natural I-ORG Resources I-ORG Research I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG 2015RC204 O to O Xiaoxu O Jia O http://www.cas.cn O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 61803347 B-AWARD 61673271 B-AWARD 81601631 B-AWARD Shanxi B-ORG Province I-ORG Science I-ORG Foundation I-ORG for I-ORG Youths I-ORG grant O number O 201801D221201 B-AWARD Opening B-ORG Foundation I-ORG of I-ORG Shanxi I-ORG Key I-ORG Laboratory I-ORG of I-ORG Advanced I-ORG Manufacturing I-ORG Technology I-ORG grant O number O XJZZ201803 B-AWARD and O Youth O Academic O Leader O Support O Project O of O North O University O of O China O grant O number O QX201808 B-AWARD This O work O was O partially O supported O by O the O National B-ORG Natural I-ORG Scientific I-ORG Foundation I-ORG No. O 82004135 B-AWARD to O Ruixiang O Zeng O the O Research B-ORG Fund I-ORG for I-ORG Zhaoyang I-ORG Talents I-ORG of I-ORG Guangdong I-ORG Provincial I-ORG Hospital I-ORG of I-ORG Chinese I-ORG Medicine I-ORG No. O ZY2022KY03 B-AWARD to O Ruixiang O Zeng O and O the O Specific B-ORG Research I-ORG Fund I-ORG for I-ORG TCM I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Guangzhou I-ORG Provincial I-ORG Hospital I-ORG of I-ORG Chinese I-ORG Medicine I-ORG YN10101915 O to O Minzhou O Zhang O The O work O is O supported O by O the O Beijing B-ORG Postdoctoral I-ORG Research I-ORG Foundation I-ORG 2014ZZ-68 O the O Postdoctoral B-ORG Scientific I-ORG Fund I-ORG of I-ORG Beijing I-ORG Academy I-ORG of I-ORG Agricultural I-ORG and I-ORG Forestry I-ORG Sciences O 2014013 O the O National B-ORG Technology I-ORG Supporting I-ORG Project I-ORG 2014BAD01B09 O the O innovation O team O construction O project O of O Beijing O Academy O of O Agricultural O and O Forestry O Sciences O JNKYT201603 O and O the O Sci-technology B-ORG Innovation I-ORG Project I-ORG of I-ORG Beijing I-ORG Academy I-ORG of I-ORG Agricultural I-ORG and I-ORG Forestry I-ORG Science I-ORG KJCX20140202 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81672841 O Clinical B-ORG Innovation I-ORG Foundation I-ORG of I-ORG Army I-ORG Medical I-ORG University I-ORG yclkt-201408 O and O Wu B-ORG Jieping I-ORG Medical I-ORG Foundation I-ORG 320.6799.15037 O This O study O was O supported O by O grants O from O the O Pew B-ORG Latin-American I-ORG Program I-ORG in I-ORG Biomedical I-ORG Science O FINEP B-AWARD 01.06.1092.00 O INCT-CNPq/MCT B-ORG INCEMAQ I-ORG 704134/2009 B-AWARD CNPq B-ORG Universal I-ORG 481506/2007-1 B-AWARD CAPES/SECYT B-ORG 152/08 B-AWARD AASDAP–Brazil O provided O supplementary O support O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O were O supported O by O the O grant O from O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0908800 O Beijing B-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospitals’ I-ORG Ascent I-ORG Plan I-ORG DFL20150601 O and O Mission B-ORG plan I-ORG SML20180601 O Beijing B-ORG Municipal I-ORG Health I-ORG Commission I-ORG “Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Center” I-ORG PXM2019_026272_000006 O PXM2019_026272_000005 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61701166 I-AWARD No. I-AWARD 41601435 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2018M632215 O the O Young B-ORG Elite I-ORG Scientists I-ORG Sponsorship I-ORG Program I-ORG by I-ORG CAST I-ORG No. O 2017QNRC001 O the O National O Science O Foundation O for O Young O Scientists O of O China O No. O 51709271 O Science O Fund O for O Distinguished O Young O Scholars O of O Jiangxi O Province O under O Grant O No.2018ACB21029 O and O the O Projects O in O the O National O Science O O Technology O Pillar O Program O during O the O Twelfth O Five-Year O Plan O Period O No. O 2015BAB07B03 O This O research O was O financially O supported O by O Beijing B-ORG Scholars I-ORG Program I-ORG BSP041 O Youth B-ORG Research I-ORG Fund I-ORG of I-ORG BAAFS I-ORG QNJJ201931 O and O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-02-11 O The O funders O had O no O role O in O the O design O of O the O experiments O data O collection O and O analysis O data O interpretation O and O also O in O writing O the O manuscript O This O work O was O supported O by O the O the B-ORG National I-ORG Natural I-ORG Scientific I-ORG Foundation I-ORG of I-ORG China I-ORG 81772045];the O Foundation I-ORG of I-ORG the I-ORG First I-ORG Affiliated I-ORG Hospital I-ORG of I-ORG Harbin I-ORG Medical I-ORG University I-ORG 2017L004];the O Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Provincial I-ORG Health I-ORG Department I-ORG 2017-049 O The O research O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81372699 O No. O 81472345 B-AWARD No. O 81672489 B-AWARD 333 B-ORG talent I-ORG project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O BRA2015394 B-AWARD Six B-ORG major I-ORG talent I-ORG summit I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O WSW-039 B-AWARD This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61974144 O 51975384 I-AWARD 51872187 O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2020B010174003 O 2019B010138002 O the O Shenzhen B-ORG University-National I-ORG Taipei I-ORG University I-ORG of I-ORG Technology I-ORG Joint I-ORG Research I-ORG Program I-ORG 2020009 O and O the O Open O Project O of O State O Key O Laboratory O of O Functional O Materials O for O Informatics O European O Union's O Horizon B-ORG 2020 I-ORG research O and O innovation O programme O under O the O Marie O Skłodowska-Curie O grant O agreement O ELBA O 765492 B-AWARD to O M.H O and O D.K.L O Spanish B-ORG Government I-ORG AGL2017-88702-C2-2-R O to O M.H O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III O FEDER O funds O PIE16/00045 O to O J.A.M O Chair O ‘Doctors O Galera-Requena O in O cancer O stem O cell O research’ O to O J.A.M O Ministry B-ORG of I-ORG Education I-ORG of I-ORG Spain I-ORG FPU13/05662 O to O R.L O and O IFI16/00041 B-AWARD to O E.A O Funding O for O open O access O charge O Instituto O de O Salud O Carlos O III O FEDER O funds O PIE16/00045 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81200806 O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 7192227 O and O Peking B-ORG University I-ORG Medicine I-ORG Seed I-ORG Fund I-ORG for I-ORG Interdisciplinary I-ORG Research I-ORG BMU O 2018MI013 O The O funders O had O no O role O in O study O design O and O decision O to O publish O This O work O was O supported O by O the O Chinese O Academy O Medical O Sciences O Initiative O for O Innovative O Medicine O grant O number O 2016-I2M-3-021 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81871695 B-AWARD the O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG grant O number O LR16H190001 B-AWARD and O the O Jiangsu B-ORG Natural I-ORG Science I-ORG Foundation I-ORG grant O number O BK20171133 B-AWARD This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31622001 O 31671845 B-AWARD 21676119 B-AWARD 31600068 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20160176 O “the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities”-China O JUSRP11725 O the O 111 B-ORG Project-China O No. O 111-2-06 B-AWARD and O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2016M600363 O 2017T100327 B-AWARD 2018M630523 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No: O 31771676 B-AWARD the O Zhejiang B-ORG Province I-ORG Public I-ORG Technology I-ORG Research I-ORG Program I-ORG Project O No: O 2015C02008 B-AWARD and O Project O No: O 2017C02027 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0700500 O and O the O Special B-ORG Funding I-ORG Projects I-ORG for I-ORG Basic I-ORG Scientific I-ORG Research I-ORG Projects I-ORG in I-ORG Universities I-ORG Project O No: O 2015QNA6005 B-AWARD This O research O was O funded O by O the O Technology B-ORG Agency I-ORG of I-ORG the I-ORG Czech I-ORG Republic O grant O numbers O TJ01000334 B-AWARD Ministry B-ORG of I-ORG Education I-ORG Youth I-ORG and I-ORG Sports I-ORG of I-ORG the I-ORG Czech I-ORG Republic O grant O number O CZ.02.1.01/0.0/0.0/15_003/0000464 B-AWARD and O Czech B-ORG Technical I-ORG University O grant O number O SGS22/188/OHK4/3T/14 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No, O 81601088 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jilin I-ORG Province I-ORG No, O 20160520164JH B-AWARD and O the B-ORG 7th I-ORG Youth I-ORG Foundation I-ORG of I-ORG the I-ORG First I-ORG Hospital I-ORG of I-ORG Jilin I-ORG University I-ORG No, O JDYY72016028 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 51908046 B-AWARD the O Key O Research O and O Development O Program O of O Shaanxi O Province O Grant O No. O 2019GY-206 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2019M653517 B-AWARD and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No. O 310823172001 B-AWARD Ministry B-ORG of I-ORG science I-ORG and I-ORG technology I-ORG of O China O 2016YFA0500700 O Strategic O Priority O Research O Program O of O the O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG XDPB10 O XDB08010101 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31330018 O 31770805 B-AWARD 91540103 B-AWARD Funding O for O open O access O charge O National O Natural O Science O Foundation O of O China O 31330018 O 31770805 O 91540103 O This O work O was O supported O by O following O grants O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0506405 O research O design O The B-ORG Strategic I-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDA23060602 O XDA2002030302 B-AWARD data O collection O Construction B-ORG Fund I-ORG for I-ORG Qinghai I-ORG Key I-ORG Laboratories I-ORG 2017-ZJ-Y23 O data O analysis O and O interpretation O Qinghai B-ORG Key I-ORG R&D I-ORG and I-ORG Transformation I-ORG Program I-ORG 2019-SF-150 O manuscript O writing O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31872881 O Outstanding B-ORG Scientist I-ORG Cultivation I-ORG Program I-ORG of I-ORG BAAFS I-ORG JKZX201907 O Special B-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Ability I-ORG Construction I-ORG of I-ORG BAAFS I-ORG KJCX20180403 O National B-ORG Science I-ORG Foundation I-ORG for I-ORG Young I-ORG Scientists I-ORG of I-ORG China I-ORG 31901490 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Beijing I-ORG 6182014 O This O work O was O supported O by O the O Construction B-ORG of I-ORG Collaborative I-ORG Innovation I-ORG Center I-ORG of I-ORG Beijing I-ORG Academy I-ORG of I-ORG Agricultural I-ORG and I-ORG Forestry I-ORG Sciences I-ORG KJCX201917 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31871519 O 31601215 B-AWARD the O China B-ORG National I-ORG Postdoctoral I-ORG Fund I-ORG 2018M631380 O and O the O Construction B-ORG of I-ORG Scientific I-ORG Research I-ORG and I-ORG Innovation I-ORG Platform I-ORG in I-ORG Beijing I-ORG Academy I-ORG of I-ORG Agriculture I-ORG and I-ORG Forestry I-ORG Sciences I-ORG PT2019-24 O This O work O was O supported O by O the O grants O from O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2108YFA0107800 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O numbers O 81920108004 B-AWARD 81770107 B-AWARD 81470362 B-AWARD and O 81702722 B-AWARD National B-ORG Postdoctoral I-ORG Program I-ORG for I-ORG Innovative I-ORG Talents I-ORG Grant O number O BX201700292 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG Grant O number O 2018JJ3703 B-AWARD Science B-ORG and I-ORG Technology I-ORG Key I-ORG Project I-ORG of I-ORG Hunan I-ORG Province I-ORG Grant O number O 2018SK21212 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG Central I-ORG South I-ORG University I-ORG Grant O number O 2018zzts386 B-AWARD The O research O leading O to O these O results O has O received O funding O from O the O European B-ORG Union I-ORG Seventh I-ORG Framework I-ORG Programme I-ORG FP7-MC-ITN O under O grant O agreement O no. O 264710 B-AWARD the O Horizon B-ORG 2020 I-ORG research I-ORG and I-ORG innovation I-ORG programme O under O grant O agreement O no. O 696656 B-AWARD and O from O the O Dutch B-ORG Polymer I-ORG Institute I-ORG DPI O under O grant O agreement O no. O EU-FP-002 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81774070 O the O Pre-research B-ORG Project I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG in I-ORG Zhejiang I-ORG University I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG 2019ZG09 O the O 2016 B-ORG Provincial I-ORG Medical I-ORG and I-ORG Health I-ORG Platform I-ORG Plan I-ORG 2016RCA024 O The O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31971505 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jilin I-ORG Province I-ORG 20170101163JC O the O Scientific B-ORG Research I-ORG Project I-ORG of I-ORG the I-ORG Department I-ORG of I-ORG Education I-ORG Jilin I-ORG Province I-ORG JJKH20200581KJ O JJKH20201180KJ O and O the O Program B-ORG of I-ORG Introducing I-ORG Talents I-ORG Discipline I-ORG to I-ORG Universities I-ORG B16011 O The O first O of O two O funders O provides O financial O support O for O the O data O collection O process O The O last O one O provides O financial O support O for O data O analysis O and O manuscript O revision O This O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81772972 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2021A1515010776 O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG Special I-ORG Project I-ORG Fund I-ORG 210728166902052 O This O study O was O funded O by O the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0501903 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31772602 O and O 31660649 B-AWARD and O the B-ORG Earmarked I-ORG Fund I-ORG for I-ORG Modern I-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG CARS-36 O The O funding O bodies O played O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O S.B O was O supported O by O a O US O Department O of O Energy O DOE O Office O of O Science O Graduate O Student O Research O award O and O by O funding O from O the O DOE O Office O of O Biological B-ORG and I-ORG Environmental I-ORG Research O through O project O 74860 B-AWARD W.R.C O was O supported O by O joint O funding O from O the O National B-ORG Institute I-ORG of I-ORG Biomedical I-ORG Imaging I-ORG and I-ORG Bioengineering I-ORG through O award O U01EB022546 B-AWARD and O by O the O DOE O Office O of O Biological O and O Environmental O Research O through O project O 69513 B-AWARD PNNL O is O operated O by O Battelle O for O the O US O DOE O under O Contract O DE-AC06-76RLO O M.A O was O supported O by O funding O from O the O DOE O Office O of O Biological O and O Environmental O Research O through O project O 74860 O the O National B-ORG Science I-ORG Foundation O grant O no. O DMS-1762063 B-AWARD through O the O joint O NSF O DMS/NIH O NIGMS O Initiative O to O Support O Research O at O the O Interface O of O the O Biological O and O Mathematical O Sciences O This O study O was O partially O funded O by O the O American B-ORG Heart I-ORG Association I-ORG 14SDG18320033 O to O KWM O and O 16PRE29910012 B-AWARD to O GSP O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG 1K01HL139859 O to O KWM O and O the O Lupus B-ORG Research I-ORG Alliance I-ORG 550778 O to O KWM O The O study O was O funded O by O RFBR B-ORG according O to O research O project O № O 20-32-90218 B-AWARD in O the O in O vivo O imaging O study O section O The O reported O study O was O partly O funded O by O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Higher I-ORG Education I-ORG of I-ORG the I-ORG Russian I-ORG Federation O state O assignment O FSRC O “Crystallography O and O Photonics” O RAS O TEM O analysis O and O Agreement O № O 075-15-2021-1357 B-AWARD within O the O state O assignment O FSRC O “Crystallography O and O Photonics” O RAS O scaffold O printing O The O article O was O prepared O as O part O of O the O work O on O the O topic O «Laser O technologies O for O biomedical O applications» O № O 122122600055-2 B-AWARD under O the O state O order O of O the O Ministry B-ORG of I-ORG Education I-ORG of I-ORG the I-ORG Russian I-ORG Federation I-ORG UCNP O synthesis O section O This O publication O was O supported O by O the O RUDN B-ORG University I-ORG Scientific I-ORG Project I-ORG Grant I-ORG System O project O № O “201904-2-00” O in O vivo O experiments O This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD1000105 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31201593 O and I-AWARD 31872940 O and O the O Agricultural B-ORG Improved I-ORG Seed I-ORG Project I-ORG of I-ORG Shandong I-ORG Province I-ORG 2019LZGC008 O Funds O were O used O for O the O experimental O payment O No O funder O has O participated O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O supported O by O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG CAAS-ASTIP-2016-ZFRI-07 O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0100704 O the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-25-03 O and O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31672178 O and I-AWARD 31471893 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG under O Grant O No. O 2017YFE0103100 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O No. O 11704333 B-AWARD and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG province I-ORG under O Grant O No. O LY16A050004 B-AWARD This O work O was O supported O by O The B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grants O 81502481 B-AWARD Foundation B-ORG of I-ORG Ninth I-ORG People’s I-ORG Hospital I-ORG Affiliated I-ORG to I-ORG Shanghai I-ORG JiaoTong I-ORG University I-ORG School I-ORG of I-ORG Medicine I-ORG 2014A05 O and O the B-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG 17DZ2260100 O This O work O was O supported O in O parts O by O the O U.S B-ORG Department I-ORG of I-ORG Energy I-ORG Office I-ORG of I-ORG Science I-ORG Office I-ORG of I-ORG Biological I-ORG and I-ORG Environmental I-ORG Research I-ORG BER O under O Award O Number O DE-PS02-09ER09-25 B-AWARD ACM O the O National B-ORG Science I-ORG Foundation I-ORG Dimensions I-ORG of I-ORG Biodiversity I-ORG program I-ORG OCE-1046297 O ACM O the O CSU B-ORG Program I-ORG for I-ORG Research I-ORG and I-ORG Education I-ORG in I-ORG Biotechnology I-ORG CSUPERB O under O award O number O GF00631142 B-AWARD RB) O and O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG of I-ORG the I-ORG National I-ORG Institutes I-ORG of I-ORG Health I-ORG under O Award O number O 8UL1GM118979-02 B-AWARD RB O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Supported O by O the O Ministry B-ORG of I-ORG Health I-ORG Czech I-ORG Republic—conceptual I-ORG development I-ORG of I-ORG a I-ORG research I-ORG organization I-ORG Institute O for I-ORG Clinical I-ORG and I-ORG Experimental I-ORG Medicine—IKEM O IN B-AWARD 00023001 O RVO B-AWARD VFN I-AWARD 64165 O and O by O the O project B-ORG National I-ORG Institute I-ORG for I-ORG Research I-ORG of I-ORG Metabolic I-ORG and I-ORG Cardiovascular I-ORG Diseases I-ORG Programme O EXCELES O Project O No. O LX22NPO5104)—Funded B-AWARD by O the O European O Union—Next O Generation O EU. O This O work O was O supported O by O the O Guangxi B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 2016GXNSFCB380003 B-AWARD and O No. O 2016GXNSFBA380144 B-AWARD Grant O form O Key B-ORG Laboratory I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG Early I-ORG Stage I-ORG Prevention I-ORG and I-ORG Control I-ORG of I-ORG Regional I-ORG high-incidence I-ORG cancer I-ORG in I-ORG Guangxi I-ORG No. O GJK201601 B-AWARD Scientific O Research O Project O of O Guangxi B-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG No. O Z2013402 B-AWARD Guangxi B-ORG Scientific I-ORG Research I-ORG and I-ORG Technology I-ORG Development I-ORG Project I-ORG No. O 14124003-1-3 B-AWARD There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81803225 B-AWARD 81703206 B-AWARD and O 81702775 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG No. O ZR2017BC004 B-AWARD and I-AWARD ZR2016HB18 O and O the O Program O of O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M630759 O This O work O was O supported O by O Tianjin B-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG grant O number O zc20065 B-AWARD the O Youth B-ORG Science I-ORG Fund I-ORG of I-ORG the I-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG Tianjin I-ORG grant O number O 20JCQNJC01370 B-AWARD and O the O Science O Fund O of O the O Nature O Science O Foundation O of O Tianjin O grant O number O 21JCZDJC00160 B-AWARD This O work O was O supported O by O the O Strategic B-ORG Award I-ORG Wellcome I-ORG Trust-Imperial I-ORG College I-ORG Centre I-ORG for I-ORG Global I-ORG Health I-ORG Research I-ORG 100693/Z/12/Z O Imperial B-ORG College I-ORG London I-ORG Wellcome I-ORG Trust I-ORG Institutional I-ORG Strategic I-ORG Support I-ORG Fund I-ORG Global O Health O Clinical O Research O Training O Fellowship O 294834/Z/16/Z O ISSF I-AWARD ICL O and O Rodrigo O M O Carrillo-Larco O is O supported O by O a O Wellcome B-ORG Trust I-ORG International I-ORG Training I-ORG Fellowship I-ORG 214185/Z/18/Z O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Young B-ORG Scientists I-ORG Fund I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41506178 O the O Young O Scientists O Fund O of O the O National O Natural O Science O Foundation O of O China O 81401578 O the O National O Natural O Science O Foundation O of O China O 81370833 O and O the O National O Major O Scientific O and O Technological O Special O Project O for O “Significant O New O Drugs O Development” O Ministry O of I-ORG Science I-ORG and I-ORG Technology O 2013ZX09J13110-07B O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O ERC-COG-863487 B-AWARD “UNIQUE” O EPSRC B-ORG UK) O “HyperTerahertz” O EP/P021859/1 O and O “TeraCom” O EP/W028921/1 O programme O grants O National B-ORG Key I-ORG R&D I-ORG Program I-ORG 2018YFB1306601 O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG “Light I-ORG of I-ORG the I-ORG West” I-ORG Talent I-ORG Training I-ORG Introduction I-ORG Program I-ORG 2019-90 O cooperation B-ORG projects I-ORG between I-ORG Chongqing I-ORG universities I-ORG in I-ORG Chongqing I-ORG and I-ORG institutions I-ORG affiliated I-ORG with I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG HZ2021011 O Chongqing B-ORG technology I-ORG innovation I-ORG and I-ORG application I-ORG development I-ORG special I-ORG cstc2021jscx-cylhX0009 O Chongqing B-ORG Technology I-ORG Innovation I-ORG and I-ORG Application I-ORG Development I-ORG Special I-ORG Major I-ORG Theme I-ORG Special I-ORG cstc2019jscx-zdztzxX0014 O This O study O was O funded O by O theNational O Institute I-ORG of I-ORG Mental I-ORG Healthgrants O USA O U01MH101719 B-AWARD U01MH0101720,Wellcome B-AWARD TrustFellowship O M.N O 110222/Z/15/Z B-AWARD R01 B-AWARD MH085953 I-AWARD CEB O U54 B-AWARD EB020403 I-AWARD CEB),Swiss O National I-ORG Science I-ORG Foundation(324730_144260 O to O SE, O National O Center O of O Competence O in O Research O NCCR O “Synapsy-The O Synaptic O Bases O of O Mental O Diseases” O 51NF40-158776 O to O S.E O S.C O was O supported O by O a O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG NHMRC O CJ O Martin O Biomedical O Fellowship O #1073726 O M.L.D O was O supported O by O a O training O award O from O the O National B-ORG Human I-ORG Genome I-ORG Research I-ORG Institute I-ORG F30HG009478 O This O work O was O supported O in O part O by O a O grant O from O the O US O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH O HG002385 B-AWARD awarded O to O E.E.E O A.S O was O supported O by O a O National O Human O Genome O Research O Institute O NHGRI O Training O Grant O 5T32HG000035-23 O E.E.E O is O an O Investigator O of O the O Howard O Hughes O Medical O Institute O RW O received O a O salary O from O Bayer O AG. O The O specific O role O of O this O author O is O articluated O in O the O author O contributions O section O We O thank O MetaboHUB B-ORG ANR-11-INBS-0010 O project O and O PHENOME B-ORG ANR-11-INBS-012 O projects O for O financing O This O study O was O also O financially O supported O by O the O German B-ORG Federal I-ORG Ministry I-ORG of I-ORG Education I-ORG and I-ORG Research I-ORG BMBF O 0315529 O and O the O European B-ORG Union I-ORG for I-ORG regional I-ORG development I-ORG EFRE O z1011bc001a O and O is O part O of O CROPSENSe.net O the O competence O network O for O phenotyping O research O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O National B-ORG Science I-ORG Fund I-ORG for I-ORG Excellent I-ORG Young I-ORG Scholars I-ORG 51322811 O Science B-ORG and I-ORG Technology I-ORG Development I-ORG Planning I-ORG of I-ORG Shandong I-ORG Province I-ORG 2012GGE27027 O Program B-ORG for I-ORG New I-ORG Century I-ORG Excellent I-ORG Talents I-ORG in I-ORG University I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG NCET-12-0341 O and O Shanghai B-ORG Tongji I-ORG Gao I-ORG Tingyao I-ORG Environmental I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Foundation I-ORG STGEF O The O MURDOCK O Study O was O funded O by O a O gift O from O the O David O H. O Murdock O Institute O for O Business O and O Culture O and O is O supported O by O Duke’s B-ORG NIH I-ORG National I-ORG Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences I-ORG NCATS I-ORG Clinical I-ORG and I-ORG Translational I-ORG Science I-ORG Award I-ORG CTSA O UL1TR002553 B-AWARD The O C3PI O Study O was O funded O by O research O grants O to O Duke O University O from O the O North B-ORG Carolina I-ORG Department I-ORG of I-ORG Health I-ORG and I-ORG Human I-ORG Services I-ORG and I-ORG the I-ORG Center I-ORG for I-ORG Disease I-ORG Control I-ORG and I-ORG Prevention I-ORG CDC O 00042568 B-AWARD and O the O Duke B-ORG Claude I-ORG D. I-ORG Pepper I-ORG Older I-ORG Americans I-ORG Independence I-ORG Center I-ORG Grant O 5P30AG028716-15 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O We O are O grateful O for O the O financial O support O of O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31571661 B-AWARD the O Specific B-ORG Foundation I-ORG of I-ORG Agronomy I-ORG No. O nyhyzx3-15 B-AWARD 201303016 O the O Bureau B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Fuling I-ORG of I-ORG Chongqing I-ORG FLKJ-2015ABB1048 O and O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG China I-ORG 2013CB127701 O The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O the O decision O to O publish O or O the O preparation O of O the O manuscript O This O work O was O funded O by O a O grant O from O the O Spanish B-ORG Ministerio I-ORG de I-ORG Ciencia I-ORG e I-ORG Innovación I-ORG CGL2009-07364 O to O Manuel O Serra O Africa O Gómez O was O supported O by O a O National B-ORG Environment I-ORG Research I-ORG Council I-ORG NERC I-ORG Advanced I-ORG Fellowship I-ORG NE/B501298/1 O and O Javier O Montero-Pau O by O a O fellowship O by O the O Spanish B-ORG Ministerio I-ORG de I-ORG Ciencia I-ORG y I-ORG Tecnología I-ORG BES2004-5248 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O project O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21676212 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2016M602833 O Shaanxi B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017BSHTDZZ14 O and O Shaanxi O Provincial O Scientific O Technology O Research O and O Development O Program O 2018KJXX-017 O This O work O was O supported O by O the O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG CIFMS I-ORG 2016-I2M-3-016 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31370327 O 31570667 B-AWARD and O 81773836 B-AWARD and O the O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 5152021 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Mega-projects B-ORG of I-ORG Science I-ORG and O Technology B-ORG Research I-ORG grant O nos O 2016ZX10004215 B-AWARD and O AWS15J006 B-AWARD the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O nos O 81371854 B-AWARD and O 81373053 O and O the O Beijing B-ORG Science I-ORG and I-ORG Technology I-ORG Nova I-ORG program I-ORG grant O no. O Z131107000413061 B-AWARD This O research O was O supported O by O Youth B-ORG Fund I-ORG of I-ORG the I-ORG Second I-ORG Hospital I-ORG of I-ORG Shandong I-ORG University(Y2015010054 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG CN) O ZR2014HL025 O and O Science B-ORG Innovation I-ORG Plan I-ORG for I-ORG Clinical I-ORG Medicine I-ORG of I-ORG Jinan I-ORG 201602150 O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O No. O 52075045 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Beijing I-ORG Municipality O China O No. O 4212047 B-AWARD and O Research B-ORG Project I-ORG of I-ORG Beijing I-ORG Education I-ORG Committee O No. O 202111232020 B-AWARD The O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31500249 O Six B-ORG Talent I-ORG Peaks I-ORG Project I-ORG in I-ORG Jiangsu I-ORG Province I-ORG 2015-NY-032 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20161381 O and O the O Foundation B-ORG of I-ORG Jiangsu I-ORG Key I-ORG Laboratory I-ORG for I-ORG the I-ORG Research I-ORG and I-ORG Uti1ization I-ORG of I-ORG Plant I-ORG Resources I-ORG SQ201401 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O financially O supported O by O Qinghai B-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG 2018-NK-133 O 2018-ZJ-T08 I-AWARD 2018-ZJ-762 I-AWARD 2019-ZJ-982Q O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31600262 O West B-ORG Light I-ORG Talent I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG and I-ORG the I-ORG Open I-ORG Project I-ORG of I-ORG the I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Plateau I-ORG Ecology I-ORG and I-ORG Agriculture I-ORG Qinghai I-ORG University I-ORG 2018-KF-06 O The O funding O body O played O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the O Program B-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O Nos O 81227901 B-AWARD 61405149 B-AWARD 81230033 B-AWARD and O 61471279 B-AWARD the O Program B-ORG of I-ORG the I-ORG National I-ORG key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG under O Grant O No. O 2016YFC0103802 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG NSIZ021402 B-AWARD and O XJS17049 B-AWARD This O work O was O supported O by: O grants O from O the O Eunice B-ORG Kennedy I-ORG Shriver I-ORG National I-ORG Institute I-ORG of I-ORG Child I-ORG Health I-ORG and I-ORG Human I-ORG Development O EG, O LEM O AJ, O DT O grant O number O P01HD070454 B-AWARD https://www.nichd.nih.gov O The O funders O did O not O play O any O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O also O supported O by O The O National B-ORG Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute O including O the O Pediatric O Cardiac O Genomics O Consortium O EG, O LEM O AJ O grant O numbers O P50-HL74731 O U01-HL098188 O U01HL131003 O U01-HL098147 O U01-HL098153 O U01-HL098163 O U01-HL098123 O U01-HL098162 O U01-HL-09003 B-AWARD https://www.nhlbi.nih.gov O The O funders O did O not O play O any O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O also O supported O by O The O National B-ORG Human I-ORG Genome I-ORG Research I-ORG Institute O EG O grant O number O U54HG006504 B-AWARD https://www.genome.gov O The O funders O did O not O play O any O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O also O supported O by O The O National O Center O for O Research O Resources O EG O grant O numbers O M01-RR-000240 O RR024134 O now O the O National B-ORG Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences O grant O number O UL1TR000003 B-AWARD https://ncats.nih.gov O The O funders O did O not O play O any O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O also O supported O by O The O American B-ORG Heart I-ORG Association O AJ O 16GRNT29660001 O https://research.americanheart.org/ris/template.jsp;jsessionid=jVQlUrw8VmQkIJKuQYwEt2rh.aharispa1?pid=ris.extlogin&_requestid=809250 O The O funders O did O not O play O any O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O financially O supported O by O the B-ORG Open I-ORG Project I-ORG of I-ORG Shanghai I-ORG Key I-ORG Laboratory I-ORG of I-ORG Forensic I-ORG Science I-ORG No O KF1402 B-AWARD and O the B-ORG Open I-ORG Project I-ORG of I-ORG Key I-ORG Laboratory I-ORG of I-ORG Prevention I-ORG and I-ORG treatment I-ORG of I-ORG cardiovascular I-ORG and I-ORG cerebrovascular I-ORG diseases I-ORG Ministry I-ORG of I-ORG Education I-ORG China I-ORG No O XN201810 B-AWARD the B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Jiangxi I-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG No O 150952 B-AWARD the B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Jiangxi I-ORG Province I-ORG No O 20133BBG70080 B-AWARD and O the B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG Jiangxi I-ORG Province I-ORG No O 20161BBG70082 B-AWARD This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21406150 O the B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG Anhui I-ORG Province I-ORG in I-ORG China I-ORG 201904a07020003 O and O the B-ORG Talent I-ORG Start-up I-ORG Fund I-ORG of I-ORG Anhui I-ORG Polytechnic I-ORG University I-ORG in I-ORG China I-ORG 2018YQQ029 O This B-ORG research I-ORG was I-ORG funded I-ORG by I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21806013 O the B-ORG project I-ORG of I-ORG Beijing I-ORG Excellent I-ORG Talents I-ORG 2016000020060G127 O and O the B-ORG open I-ORG projects I-ORG of I-ORG Beijing I-ORG Research I-ORG Center I-ORG for I-ORG Agricultural I-ORG Standards I-ORG and I-ORG Testing I-ORG KFKT201709 O This O work O was O supported O by O the O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG grant O number O MOP-81105 B-AWARD Medical B-ORG Research I-ORG Council I-ORG UK O grant O number O G1001235 B-AWARD and O European B-ORG Union’s I-ORG Horizon I-ORG 2020 I-ORG OPEN I-ORG FET I-ORG RIA I-ORG NEURAM O 712821 B-AWARD This O work O was O funded O by O Breeding B-ORG of I-ORG new I-ORG varieties I-ORG of I-ORG genetically I-ORG modified I-ORG organisms I-ORG Project I-ORG 2018ZX0801010B-003 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31702078 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2662018QD002 O This O work O was O supported O by O the O National B-ORG Cancer I-ORG Institute I-ORG NCI I-ORG of I-ORG the I-ORG National I-ORG Institutes I-ORG of I-ORG Health I-ORG under O R01CA231139 B-AWARD and O MH O was O also O supported O by O U54 B-ORG Career I-ORG Enhancement I-ORG Core I-ORG under O U54CA229973 B-AWARD AYK O was O also O supported O by O NCI O P30CA225520 O and O the O Oklahoma B-ORG Tobacco I-ORG Settlement I-ORG Endowment I-ORG Trust I-ORG TSET O R23-02 O This O work O was O supported O by O the O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG BBSRC I-ORG Doctoral O Training O Programme O Award O BB/J014478/1 B-AWARD S.O’K O a O Welcome B-ORG Trust I-ORG Investigator I-ORG Award I-ORG in I-ORG Science I-ORG 204957/Z/16/Z B-AWARD S.H O and O a O Grant-in-Aid O for O Scientific O Research O C) O from O the O Japanese B-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG JSPS O KAKENHI O JP17K08362 B-AWARD A.K O This O research O was O financially O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 31302035 B-AWARD Jiangsu B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O BK2012273 B-AWARD National O Natural O Science O Foundation O of O China O grant O no. O 31272499 B-AWARD and O Natural B-ORG science I-ORG fund I-ORG for I-ORG colleges I-ORG and I-ORG universities I-ORG in I-ORG Jiangsu I-ORG Province I-ORG grant O no. O 13KJD230001 B-AWARD The O present O study O was O financially O supported O by O grants O from O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG in I-ORG 2020 I-ORG no.H2020201050 O High-level B-ORG Talents I-ORG Scientific I-ORG Research I-ORG Launched I-ORG Project I-ORG of I-ORG Hebei I-ORG University(no.521000981301 O Government-funded B-ORG Clinical I-ORG Medicine I-ORG Outstanding I-ORG Talent I-ORG Training I-ORG Project(Team I-ORG in I-ORG 2019(no.360017 O Science B-ORG and I-ORG Technology I-ORG Capacity I-ORG Improvement I-ORG Projects I-ORG of I-ORG Hebei I-ORG University I-ORG of I-ORG Chinese I-ORG Medicine I-ORG in I-ORG 2019 I-ORG no.KTZ2019019 O Outstanding B-ORG Student I-ORG Scientific I-ORG Research I-ORG Ability I-ORG Improvement I-ORG Projects I-ORG of I-ORG Hebei I-ORG University I-ORG of I-ORG Chinese I-ORG Medicine I-ORG in I-ORG 2019 I-ORG no.YXZ2019002 O Graduate B-ORG Innovative I-ORG Ability I-ORG Training I-ORG Projects I-ORG of I-ORG Hebei I-ORG University I-ORG of I-ORG Chinese I-ORG Medicine I-ORG in I-ORG 2020 I-ORG no.XCXZZBS2020002 O Graduate B-ORG Innovative I-ORG Ability I-ORG Training I-ORG Projects I-ORG of I-ORG Hebei I-ORG University I-ORG in I-ORG 2020 I-ORG no.hbu2020bs003 O Foundation B-ORG Project I-ORG of I-ORG Affiliated I-ORG Hospital I-ORG of I-ORG Hebei I-ORG University I-ORG in I-ORG 2019 I-ORG no.2019Q009 O This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFD0200804 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O grants O 31700094 B-AWARD 31770115 B-AWARD and O 31600090 B-AWARD the B-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG Pillar I-ORG Program I-ORG of I-ORG China I-ORG 2014BAD16B02 O and O the B-ORG funds I-ORG of I-ORG Shandong I-ORG “Double I-ORG Tops” I-ORG Program I-ORG SYL2017XTTD03 O The O above O funds O played O no O role O in O study O design O data O analysis O and O manuscript O preparation O The O opinions O expressed O in O this O paper O are O those O of O the O authors O This O work O has O been O financially O supported O by O the O Ministry B-ORG of I-ORG Education I-ORG Youth I-ORG and I-ORG Sports I-ORG of I-ORG the I-ORG Czech I-ORG Republic I-ORG under O the O project O CEITEC B-AWARD 2020 I-AWARD LQ1601 I-AWARD and O Czech B-ORG Science I-ORG Foundation I-ORG 13-25401S O Additional O computational O resources O were O provided O by O the O CESNET O LM2015042 O and O the O CERIT O Scientific O Cloud O LM2015085 O provided O under O the O programme O Projects O of O Large O Research O Development O and O Innovations O Infrastructures O The O research O has O been O financed O by O the O program O SASPRO B-ORG ArIDARuM O 0005/01/02 I-AWARD O SK) O and O was O co-funded O by O the O People O Programme O Marie O Curie O Actions O 7FP O grant O agreement O REA O no. O 609427 O O SK) O and O co-financed O by O the O Slovak O Academy O of O Sciences O SKM O is O an O international O fellow O of O the O Japan O Society O for O Proportion O of O Science O This O work O was O supported O by O the O National B-ORG key I-ORG research I-ORG and I-ORG development I-ORG program I-ORG 2022YFC3602401 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82170437 O and O Central B-ORG South I-ORG University I-ORG Innovation-Driven I-ORG Research I-ORG Program I-ORG 2023CXQD007 O The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O the O Project O PTDC/CVT-CVT/4620/2021 B-AWARD funded O by O FEDER B-ORG funds I-ORG through I-ORG COMPETE2020–Programa I-ORG Operacional I-ORG Competitividade I-ORG e I-ORG Internacionalização I-ORG POCI O and O by O national O funds O PIDDAC O through O FCT/MCTES B-ORG It O was O also O supported O by: O LA/P/0045/2020 B-AWARD ALiCE O UIDB/00511/2020 B-AWARD and O UIDP/00511/2020 B-AWARD LEPABE O funded O by O national B-ORG funds I-ORG through I-ORG FCT/MCTES I-ORG PIDDAC O In O addition O this O work O was O also O funded O by O FCT O Portuguese O Foundation O for O Science O and O Technology O under O strategic O projects O UIDP/CVT/00772/2020 B-AWARD CECAV I-AWARD and O LA/P/0059/2020 B-AWARD AL4AnimalS O and O under O the O scope O of O the O strategic O funding O of O UIDB/04469/2020 B-AWARD unit O CEB O J.C O also O thanks O FCT B-ORG for I-ORG the I-ORG CEEC I-ORG Individual I-ORG 2022.06886.CEECIND O This O work O was O supported O by O the B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG of I-ORG Hunan I-ORG Province I-ORG 2022RC1025 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. I-AWARD 31801736 O and O the B-ORG Double I-ORG first-class I-ORG construction I-ORG project I-ORG of I-ORG Hunan I-ORG Agricultural I-ORG University I-ORG Grant O No. O SYL2019029 B-AWARD This O work O has O been O supported O by O grants O from O Key B-ORG project I-ORG of I-ORG the I-ORG natural I-ORG science I-ORG foundation I-ORG in I-ORG Heilongjiang I-ORG Province I-ORG ZD2017020 O PhD B-ORG star-up I-ORG fund I-ORG of I-ORG Liaoning I-ORG Province I-ORG 20180540019 O Open B-ORG Research I-ORG Fund I-ORG of I-ORG Shandong I-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Infectious I-ORG Disease I-ORG Control I-ORG and I-ORG Prevention O Shandong O Center O for O Disease O Control O and O Prevention O 2017KEYLAB-03 O The O funders O had O no O role O in O the O design O of O the O study O or O in O the O collection O analysis O or O interpretation O of O the O data O This O work O was O supported O by O the O Youth B-ORG Program I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81801142 B-AWARD and O Beijing B-ORG Hospitals I-ORG Authority I-ORG Youth I-ORG Program I-ORG No. O QMS20200801 B-AWARD to O Yuan O Wang O Qingfeng O Ma O was O supported O by O Beijing B-ORG Hospitals I-ORG Authority I-ORG Cultivation I-ORG Program I-ORG No. O PG2020017 B-AWARD This O work O was O supported O by O FP7 O projects O QualityNano B-ORG INFRA-2010-262163 O ICN-TAF-176 O and O by O the O Doctoral O School O of O Semmelweis O Univerity O Budapest O to O K.K O by O the O EU O 7th O framework O programme O Marie B-ORG Curie I-ORG Actions O Network O for O Initial O Training O NanoTOES O PITN-GA-2010-264506 O to O K.M O and O by O the O Hungarian B-ORG National I-ORG Science I-ORG Fund I-ORG OTKA O Grant O No O K106191 B-AWARD and O Bio O Surf O Nat O Office O of O Res O and O Dev O NKTH B-ORG Grant O No O TECH-08-A1-2008-0276 B-AWARD to O EM. O The O funding O bodies O did O not O contribute O to O the O design O of O the O study O to O collection O analysis O and O interpretation O of O the O data O or O to O the O writing O of O the O manuscript O This O work O was O supported O by O grants O from O theSwedish O Research I-ORG Council(2011/488,2013/3477 O theSwedish O Radiation I-ORG Safety I-ORG Authority(2014/2641 O theSwedish O Federal I-ORG Governmentunder O the O LUA/ALF O agreement O ALFGBG-428961 O and O the O Health O and O Medical O Care O Committee O of O theRegion O Västra I-ORG Götaland(VGFOUREG-483951 O This O work O was O supported O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2572017EB06 O the O Self-determined B-ORG and I-ORG Innovative I-ORG Research I-ORG Funds I-ORG of I-ORG NEFU I-ORG 2572017AB13 O and O the O National B-ORG Undergraduate I-ORG Training I-ORG Programs I-ORG for I-ORG Innovations I-ORG 201710225063 O Y. O Xu O acknowledges O the O support O from O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 O Program O No. O 2015CB351902 B-AWARD the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG 2018ZX01005105 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O U1431231 B-AWARD Beijing B-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG Grant O No. O Z151100001615042 B-AWARD Key B-ORG Research I-ORG Projects I-ORG of I-ORG the I-ORG Frontier I-ORG Science I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG No. O QYZDY-SSW-JSC004 B-AWARD and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG No.2016YFB0400601 O and O No.2016YFB0402402 O This O work O is O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O No. O 31070089 B-AWARD J1103514 B-AWARD and O 31170078 B-AWARD the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O Nos O 2014AA093510 B-AWARD and O 2013AA065805 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG grant O No. O 2015CFA085 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for O HUST O grant O Nos O 2014NY007 B-AWARD 2017KFTSZZ001 B-AWARD 2017KFXKJC010 B-AWARD and O 2017KFYXJJ212 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O National O key O research O and O development O plan O special O project O for O synthetic O biology O 2018YFA0902500 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31470389 O Postdoctoral B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 2019M653013 O and O Guangdong B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2019A1515011701 O This O work O was O supported O by O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG CAS I-ORG XDA22040502 O The B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0304905 O 2018YFC0309804 B-AWARD and O Major B-ORG scientific I-ORG and I-ORG technological I-ORG projects I-ORG of I-ORG Hainan I-ORG Province I-ORG ZDKJ2016012 O The O funding O bodies O had O no O role O in O the O design O of O the O study O the O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grants O 81871694 B-AWARD 81773447 B-AWARD 81561128006 B-AWARD 21778074 B-AWARD 31470801 B-AWARD 81661148055 B-AWARD and O 81630090 O the O National B-ORG Major I-ORG Project I-ORG of I-ORG the I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Infectious I-ORG Diseases I-ORG Prevention I-ORG and I-ORG Control I-ORG Grant O 2011SKLID102 B-AWARD and O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG Grant O 2018ZX10101002 B-AWARD This O work O was O supported O by O Research O grant O of O the O State B-ORG Committee I-ORG of I-ORG Science O Ministry O of O Education O and O Science O of O Armenia O to O AT O #AB16-37 O and O Armenian B-ORG National I-ORG Science I-ORG and I-ORG Education I-ORG Fund I-ORG USA O Research O grants O to O AP O #NS-Biotech-4376 O and O Biotech-5285 B-AWARD German B-ORG Academic I-ORG Exchange I-ORG Service I-ORG DAAD O Scholarship O to O AP O #91696388 O This O work O was O partly O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 21502176 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG no. O 2015M582207 B-AWARD Postdoctoral O Research O Sponsorship O in O Henan O Province O 2015001 O Startup B-ORG Research I-ORG Fund I-ORG of I-ORG Zhengzhou I-ORG University I-ORG 145-51090119 O and O the O National O Department O of O Public O Benefit O Research O Foundation O 201403031 O This O research O was O funded O by O a O Project O Grant O from O the O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG to O R.R O and O KB O NHMRC O APP1086855 B-AWARD an O Australian B-ORG Research I-ORG Council I-ORG Discovery O Early O Career O Researcher O Award O DE170100392 O to O K.D.B O and O a O Sir B-AWARD Keith I-AWARD Murdoch I-AWARD Fellowship I-AWARD from O the O American B-ORG Australian I-ORG Association I-ORG to O K.S.Z O This O research O was O funded O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31272528 B-AWARD 31772700 B-AWARD the O Jilin B-ORG Scientific I-ORG and I-ORG Technological I-ORG Development I-ORG Program I-ORG No. O 20180101244JC B-AWARD and O the O Program B-ORG for I-ORG New I-ORG Century I-ORG Excellent I-ORG Talents I-ORG in I-ORG University I-ORG of O China O No. O NCET-12-0232 B-AWARD This O research O was O funded O by O the O European B-ORG Research I-ORG Council I-ORG ERC O under O the O European O Union’s O Horizon O 2020 O Research O and O Innovation O Program O under O Grant O Agreement O No. B-AWARD 715737 I-AWARD QuantSURG O S.G O and O the O Agence B-ORG Nationale I-ORG de I-ORG la I-ORG Recherche I-ORG under O Grant O Agreement O No. B-AWARD ANR-18-CE19-0026 I-AWARD LiverSURG O S.G O This O work O has O been O supported O by O the O research O project O “HyperSIGHT” O ID O R18SF4YHHS B-AWARD funded O by O the O Italian B-ORG Ministry I-ORG of I-ORG University I-ORG and I-ORG Research I-ORG Call O FARE O Ricerca O 2018 O This O research O was O supported O by O NIH/NIEHS B-ORG RIVER I-ORG award O R35 B-AWARD ES030443 I-AWARD BDH O NIH/NIEHS B-ORG Superfund I-ORG Research I-ORG Program I-ORG P42 B-AWARD ES004699 I-AWARD BDH O and O NIH/NHLBI B-ORG T32HL086350 B-AWARD NS I-AWARD This O work O is O supported O by O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61672329 I-AWARD No. I-AWARD 61472233 I-AWARD No. I-AWARD 61572300 I-AWARD No. I-AWARD 81273704 O Shandong B-ORG Provincial I-ORG Project I-ORG of I-ORG Graduate I-ORG Education I-ORG Quality I-ORG Improvement I-ORG No.SDYY18058 O Taishan B-ORG Scholar I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG No. O TSHW201502038 I-AWARD No.20110819 O This O work O is O financially O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFB0401105 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51635007 O 51605180 O Special B-ORG Project I-ORG of I-ORG Technology I-ORG Innovation I-ORG of I-ORG Hubei I-ORG Province I-ORG 2017AAA002 O Program O for O HUST O Academic O Frontier O Youth O Team O and O Program O for O Guangdong O Introducing O Innovative O and O Entrepreneurial O Teams O 2017ZT07G331 O This O research O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hainan I-ORG Province I-ORG 318MS092 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31771859 O the O Central O Public-Interest O Scientific O Institution O Basal O Research O Fund O for O Chinese O Academy O of O Tropical O Agricultural O Sciences O 1630052016005 O 1630052016006 O 1630052017021 O 1630012019009 O 1630052019023 O the O Central O Public-Interest O Scientific O Institution O Basal O Research O Fund O for O Innovative O Research O Team O Program O of O CATAS O 17CXTD-28 O 1630052017017 O and O the O earmarked B-ORG fund I-ORG for I-ORG Modern I-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG CARS-11 O This O study O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31622014 O and I-AWARD 31570426 O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0506100 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 17lgzd24 O to O Chengjin O Chu O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O financially O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31301972 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Province I-ORG 1308085QC66 O Earmarked B-ORG Fund I-ORG for I-ORG Modern I-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG CARS-37-04B O and O the O Scientific B-ORG Special I-ORG Expenditure I-ORG for I-ORG Non-profit I-ORG Public I-ORG Industry I-ORG Agriculture I-ORG 201003060 O The O present O study O is O supported O by O the O Science O Foundation O of O the O project O of O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG No. O 15411965300 B-AWARD the O project O of O the O Shanghai B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG No. O 201540067 B-AWARD and O the O project O of O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81400910 B-AWARD This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81901071 O the B-ORG Joint I-ORG Funds I-ORG for I-ORG the I-ORG Innovation I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Fujian I-ORG Province I-ORG 2021Y9001 O and O 2021Y9030 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG 2019J05072 O and O 2021J05050 B-AWARD and O Fujian B-ORG Medical I-ORG University I-ORG XRCZX2021009 O This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31871637 O and O the O Young B-ORG Scientists I-ORG Fund I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2016JQ0008 O and O the O Key B-ORG Fund I-ORG of I-ORG the I-ORG Department I-ORG of I-ORG Education I-ORG of I-ORG Sichuan I-ORG Province I-ORG 15ZA0004 O This O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31572179 O 31600054 O Coal-based B-ORG Key I-ORG Scientific I-ORG and I-ORG Technological I-ORG Project I-ORG from I-ORG Shanxi I-ORG Province I-ORG FT2014-03-01 O and O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG from I-ORG Guangxi I-ORG Province I-ORG 2016AB05317 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O No. O 81300747 B-AWARD and O No. O 81270014 B-AWARD and O the O Specialized B-ORG Research I-ORG Fund I-ORG for I-ORG the I-ORG Doctoral I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG SRFDP O No. O 20130071120096 B-AWARD and O the O Excellent B-ORG Young I-ORG Doctor I-ORG Training I-ORG Program I-ORG of I-ORG Shanghai I-ORG 2015 O This O work O was O supported O by O a O University B-ORG of I-ORG Leeds I-ORG PhD I-ORG scholarship I-ORG 11061191 O to O G.T O a O UK B-ORG Research I-ORG and I-ORG Innovation I-ORG Rutherford I-ORG Fund I-ORG Fellowship I-ORG MR/ O S00386X/1 I-AWARD to O A.D O and O a O University B-ORG of I-ORG Leeds I-ORG Academic I-ORG Fellowship I-ORG 11061187 O to O L.F.S O This O work O was O supported O by O the O National B-ORG Nonprofit I-ORG Institute I-ORG Research I-ORG Grant I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Forestry I-ORG Grant O number O CAFYBB2014MA005 B-AWARD No O URL O Full O name O of O funding O institution O is O Chinese O Academy O of O Forestry O Author O who O received O the O funding O is O JH O Jihong O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O number O 41471048 B-AWARD the O URL:http://www.nsfc.gov.cn O Full O name O of O funding O institution O is O National O Natural O Science O Foundation O of O China O Author O who O received O the O funding O is O JH O Jihong O and O the O National B-ORG Nonprofit I-ORG Institute I-ORG Research I-ORG Grant I-ORG of I-ORG the I-ORG Institute I-ORG of I-ORG Forest I-ORG Ecology I-ORG Environmental I-ORG and I-ORG Protection I-ORG Chinese I-ORG Academy I-ORG of I-ORG Forestry I-ORG Grant O number O CAFIFEEP2015B02 B-AWARD No O URL O Full O name O of O funding O institution O is O Institute O of O Forest O Ecology O Environmental O and O Protection O Chinese O Academy O of O Forestry O Author O who O received O the O funding O is O JH O Jihong O This O work O was O supported O by O the O Department O of O Health O through O the O SBRI B-ORG Innovate I-ORG UK I-ORG grant I-ORG project O Nos O 972212 B-AWARD and O 971557 B-AWARD A.R.-S O Y.C.K O is O supported O by O the O Wellcome B-ORG Trust I-ORG Grant I-ORG 224117/Z/21/Z O This O publication O resulted O in O part O from O research O supported O by O the O Consejo B-ORG Nacional I-ORG de I-ORG Ciencia I-ORG y I-ORG Tecnologia I-ORG CONACyT O Mexico O which O funded O the O doctoral O training O of O student O G.M.Z.-F O scholar O number O 580467 O awarded O with O the O scholarship O 472337 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U22A20576 O High B-ORG Level I-ORG Talents I-ORG Project I-ORG of I-ORG Shanxi I-ORG Agricultural I-ORG University I-ORG 2021XG008 O Shanxi B-ORG Key I-ORG Laboratory I-ORG Project I-ORG 202104010910017 O and O the O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Fund I-ORG of I-ORG Shanxi I-ORG Agricultural I-ORG University I-ORG SXBYKY2021052 O SXBYKY2021053 B-AWARD This O work O was O supported O by O the O Shandong B-ORG Province I-ORG Postdoctoral I-ORG Innovation I-ORG Project I-ORG 201702044 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017M612312 O a O Project B-ORG of I-ORG Shandong I-ORG Province I-ORG Higher I-ORG Educational I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG J17KA149 O as O well O as O the O Provincial B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shandong I-ORG 2017CXGC0207 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 3072022QBZ1001 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 52103256 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG LH2019E038 O This O research O was O funded O by O the O Anhui B-ORG Provincial I-ORG Scientific I-ORG Research I-ORG Preparatory I-ORG Project’ O title O name O is O “Research O on O the O Mechanism O and O Industrialization O of O Rice O Protein O and O Pea O Protein O to O Produce O Plant O Meat” O 2022AH040157 O the O Open B-ORG Project I-ORG Program I-ORG of I-ORG the I-ORG National I-ORG Soybean I-ORG Processing I-ORG Industry I-ORG Technology I-ORG Innovation I-ORG Center I-ORG Programme I-ORG Grant O DDJGCY001 O the O Chuzhou B-ORG University I-ORG scientific I-ORG research I-ORG fund I-ORG Programme I-ORG Grant O 2020qd34 O the O Key B-ORG R&D I-ORG project I-ORG of I-ORG Anhui I-ORG Provincial I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG “Development O and O industrialization O of O key O technology O of O rice O protein O plant O meat” O 202204c06020081 O and O the O project B-ORG entrusted I-ORG by I-ORG Anhui I-ORG Shunxin I-ORG Shengyuan I-ORG Biological I-ORG Food I-ORG Co I-ORG Ltd I-ORG “Rice O protein O plant O meat O processing O technology O and O product O quality O control” O HX2022050 O This O work O was O supported O by O grants O from O the B-ORG National I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 I-ORG Program I-ORG No. O 2014CB542300 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31271378 O the B-ORG Research I-ORG Special I-ORG Fund I-ORG for I-ORG Public I-ORG Welfare I-ORG Industry I-ORG of I-ORG Health I-ORG No. O 201302018 O and O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O BE2016737 O This O work O was O funded O by O the O National B-ORG Science I-ORG Centre I-ORG Poland O through O the O MAESTRO O 6 O grant O programme O application O number O 2014/14/A/ST4/00640 B-AWARD This O work O was O also O supported O by O STSM O Grant O from O COST B-ORG Action I-ORG 16112 B-AWARD and O by O the O Ministry B-ORG of I-ORG Science I-ORG Technological I-ORG Development I-ORG and I-ORG Innovation I-ORG of I-ORG the I-ORG Republic I-ORG of I-ORG Serbia O Contract B-AWARD No. I-AWARD 451-03-47/2023-01/200007 O The O funders O had O no O role O in O the O design O of O the O study O in O the O collection O analyses O or O interpretation O of O data O in O the O writing O of O the O manuscript O or O in O the O decision O to O publish O the O results O This O work O was O supported O by O the10.13039/100010663European O Research I-ORG Council(ERC O Grant O name O “MODVASC” O number O 759248 B-AWARD and O the10.13039/100004807DFG(SFB834 O project O number O 75732319 B-AWARD to O K. O Stellos O ELKE O grants O from O the10.13039/501100005187National O and I-ORG Kapodistrian I-ORG University I-ORG of I-ORG Athens I-ORG Greeceto O P.P O Sfikakis O grant O number O 0974];AIRCIG B-AWARD n. O 22080 B-AWARD to O A.Gallo O and O a O scholarship O for O doctoral O studies O to O N.I.V O by O A. O Onassis O Public O Benefit O Foundation O The O project O is O supported O by O ERC B-ORG grant I-ORG blackQD I-ORG grant O n° O 756225 B-AWARD Ne2Dem B-ORG grant O n° O 853049 B-AWARD and O AQDtive B-ORG grant O n° O 101086358 B-AWARD We O acknowledge O the O use O of O clean-room O facilities O from O the O “Centrale O de O Proximité O Paris-Centre” O and O from O the O STnano O platform O This O work O has O been O supported O by O the O Region B-ORG Ile-de-France I-ORG in O the O framework O of O DIM O Nano-K O grant O dopQD B-AWARD This O work O was O supported O by O French B-ORG state I-ORG funds I-ORG managed O by O the O ANR O within O the O Investissements O d’Avenir O programme O under O reference O ANR-11-IDEX-0004-02 B-AWARD and O Labex B-ORG NIE I-ORG ANR-11-LABX-0058 O and O ANR-10-IDEX-0002-02 B-AWARD and O more O specifically O within O the O framework O of O the O Cluster B-ORG of I-ORG Excellence I-ORG MATISSE I-ORG and I-ORG also I-ORG by I-ORG the I-ORG grant I-ORG IPER-Nano2 I-ORG ANR-18CE30-0023-01 O Copin B-ORG ANR-19-CE24-0022 O Frontal B-ORG ANR-19-CE09-0017 O Graskop B-ORG ANR-19-CE09-0026 O NITQuantum B-ORG ANR-20-ASTR-0008-01 O Bright B-ORG ANR-21-CE24-0012-02 O MixDferro B-ORG ANR-21-CE09-0029 O and O Quicktera B-ORG ANR-22-CE09-0018 O This O work O was O supported O in O part O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG under O Grant O 2019YFB1600500 B-AWARD in O part O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51908054 O 51775053 B-AWARD in O part O by O the O Key O Research O and O Development O Program O of O Shaanxi O under O Grant O 2020GY-163 O 2019ZDLGY03-09-02 O and O in O part O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities O CHD B-AWARD 300102220202 I-AWARD This O research O was O funded O by O the O Zhejiang B-ORG Province I-ORG Public I-ORG Welfare I-ORG Technology I-ORG Application I-ORG Research I-ORG Project I-ORG grant O number O LGN21 B-AWARD C170001 O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O LQ22 B-AWARD C170003 O Zhejiang B-ORG Province I-ORG Major I-ORG Agricultural I-ORG Technology I-ORG Collaborative I-ORG Promotion I-ORG Project I-ORG grant O number O 2021 B-AWARD XTTGXM06–03 O and O Key B-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG Hangzhou I-ORG City I-ORG grant O number O 2020 B-AWARD ZDSJ0909 O This O work O was O supported O by O grants O from O theNational O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China(No O 81770399 B-AWARD 81470516 B-AWARD 81530012 B-AWARD 81700353 B-AWARD theFundamental O Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG China(2042018kf0121),National O Key I-ORG R&D I-ORG Program I-ORG of I-ORG China(2018YFC1311300 O andDevelopment O Center I-ORG for I-ORG Medical I-ORG Science I-ORG and I-ORG Technology I-ORG National I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG the I-ORG People's I-ORG Republic I-ORG of I-ORG China(The O prevention O and O control O project O of O cardiovascular O disease O 2016ZX-008-01 B-AWARD This O study O was O supported O by O the O Cultivating B-ORG grand I-ORG for I-ORG youth I-ORG key I-ORG teacher I-ORG in I-ORG Higher I-ORG Education I-ORG Institutions I-ORG of I-ORG Henan I-ORG province I-ORG NO: O 2017GGJS012 B-AWARD Natural B-ORG Science I-ORG Fund I-ORG of I-ORG Henan I-ORG Province I-ORG NO: O 182300410303 B-AWARD Science B-ORG and I-ORG Technology I-ORG Key I-ORG Project I-ORG of I-ORG Henan I-ORG province I-ORG NO: O 172102310373 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO: O 81001280 B-AWARD 81202277 B-AWARD The O funding O source O played O no O role O in O the O design O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O project O was O funded O by O the O by O VA B-ORG Clinical I-ORG Science I-ORG research I-ORG and I-ORG Development I-ORG investigator O initiated O grant O CX000570-01 B-AWARD Roumie O and O the O Center B-ORG for I-ORG Diabetes I-ORG Translation I-ORG Research I-ORG P30DK092986 B-AWARD Roumie O Dr. O Hung O 2-031-09S O was O supported O by O VA B-ORG Career I-ORG Development I-ORG Award O Support O for O Veterans O Affairs/Centers O for O Medicare O O Medicaid O Services O data O provided O by O the O Department O of O Veterans O Affairs O Veterans O Affairs O Health O Services O Research O and O Development O Service O Veterans O Affairs O Information O Resource O Center O project O numbers O SDR O 02–237 O and O 98–004 O The O study O was O funded O by O the O Zhejiang B-ORG Federation I-ORG of I-ORG Humanities I-ORG and I-ORG Social I-ORG Sciences I-ORG Grant O No. O 22NDQN298YB B-AWARD Provincial B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG Grant O No. O LD22H190001 B-AWARD and O Medical B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Ningbo I-ORG City I-ORG Grant O No. O 2021Y66 B-AWARD This O work O was O funded O by O NIH B-ORG grant O R01-AG063544 B-AWARD to O T.-Y.C O and O C.C.Y.C O We O acknowledge O the O work O and O resources O provided O by O the O Dartmouth B-ORG bioMT I-ORG core I-ORG NIH/NIHMS I-ORG COBRE I-ORG award O No. O P20-GM113132 B-AWARD Dartmouth B-ORG Cancer I-ORG Center I-ORG Core I-ORG NIH I-ORG grant O No. O P30-CA023108 B-AWARD NIH O grant O R35-GM122545 B-AWARD to O H.N.H O and O NIH O grant O R01-HL155824 B-AWARD to O R.V.S O We O acknowledge O the O IDeA O National O Resource O for O Quantitative O Proteomics O conducting O the O proteomic O work O described O in O this O study O funded O by O NIH O grant O No. O R24GM137786 B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YED0201003 B-AWARD the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-25 O and O the O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG CAASASTIP-IVFCAAS O CD O and O QS’s O work O were O supported O by O these O funding O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 71473152 O Department B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Shandong I-ORG Province I-ORG BS2012SF010 O and O Independent B-ORG Innovation I-ORG Foundation I-ORG of I-ORG Shandong I-ORG University I-ORG 2012DX006 O US O National B-ORG Human I-ORG Genome I-ORG Research I-ORG Institute I-ORG U24 O HG002223 O UK O Medical B-ORG Research I-ORG Council I-ORG MR/S000453/1 O UK O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG BB/P024602/1 O Funding O for O open O access O charge O US O National O Human O Genome O Research O Institute O U24 O HG002223 O Financial O support O was O provided O by O the O Netherlands B-ORG Organization I-ORG for I-ORG Scientific I-ORG Research I-ORG NWO I-ORG Cancer I-ORG Genomics I-ORG Netherlands I-ORG CGCNL I-ORG Cancer I-ORG Systems I-ORG Biology I-ORG Center I-ORG CSBC I-ORG the I-ORG Netherlands I-ORG Genomics I-ORG Initiative I-ORG NGI I-ORG grants O Zenith O 93512009 B-AWARD J.J O and O VICI O 91814643 B-AWARD J.J. O the O EU B-ORG Seventh I-ORG Framework I-ORG Program I-ORG EurocanPlatform O project O 260791 B-AWARD J.J O and O Infrafrontier-I3 B-ORG project O 312325 B-AWARD J.J. O the O European O Research O Council O ERC O Synergy O project O CombatCancer O and O a O National O Roadmap O grant O for O Large-Scale O Research O Facilities O from O NWO O J.J O This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 41701247 B-AWARD No. O 51609229 B-AWARD No. O 41771266 B-AWARD the O Fundamental B-ORG and I-ORG Frontier I-ORG Research I-ORG Project I-ORG of I-ORG Chongqing I-ORG No. O cstc2017jcyjAX0415 B-AWARD and O the O Chongqing B-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG No. O cstc2017jcyjAX0241 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31730078 O to O H.S.G,http://www.nsfc.gov.cn O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDB11040500 O to O H.S.G,http://www.cas.ac.cn O and O Science B-ORG and I-ORG Technology I-ORG Services I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG KFJ-STS-ZDTP-058 O to O H.S.G.,http://www.cas.ac.cn O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the O Major B-ORG Scientific I-ORG I-ORG Technological I-ORG Projects I-ORG of I-ORG Hainan I-ORG Province I-ORG grant O No. O ZDKJ2016020 B-AWARD the O Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG for I-ORG Chinese I-ORG Academy I-ORG of I-ORG Tropical I-ORG Agricultural I-ORG Sciences I-ORG grant O No. O 1630022015001 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O grant O No. O 31770642 B-AWARD This O work O has O been O supported O by O the O financial O support O of O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 2572018BH01 B-AWARD National B-ORG Undergraduate I-ORG Innovation I-ORG Project I-ORG No. O 201610225050 B-AWARD and O Specialized B-ORG Personnel I-ORG Start-up I-ORG Grant O Also O National O Construction O Plan O of O World-class O Universities O and O First-class O Disciplines O No. O 41113237 B-AWARD The O funding O body O of O Fundamental O Research O Funds O for O the O Central O Universities O played O an O important O role O in O the O design O of O the O study O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O JEK O is O supported O by O a O post-doctoral O fellowship O from O CNPq B-ORG 501891/2013-7 O This O research O was O supported O by O grants O from O CNPq O 483775/2012-6 O and O CAPES B-ORG edital O 051/2013 O both O to O SJS O and O grants O D43TW007015 B-AWARD and O U54HL108460 B-AWARD from O NIH B-ORG to O LOM O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 82060435 B-AWARD the O Project B-ORG of I-ORG the I-ORG Jiangxi I-ORG Provincial I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG no. O 20202BAB206052 B-AWARD and O the O Project B-ORG of I-ORG the I-ORG Jiangxi I-ORG Provincial I-ORG Innovation I-ORG Fund I-ORG for I-ORG Graduate I-ORG Students I-ORG no. O YC2021-B041 B-AWARD National B-ORG Institutes I-ORG of I-ORG Health I-ORG R01 O ES024872 I-AWARD and O R01 B-AWARD ES030335 I-AWARD to O K.A.B O R01CA238315 B-AWARD and O 5R01CA218026 B-AWARD to O R.J.B O American B-ORG Cancer I-ORG Society I-ORG 129182-RSG-16-043-01-DMC O to O K.A.B O Stand B-ORG Up I-ORG To I-ORG Cancer I-ORG SU2C-AACR-IRG-02-16 O to O K.A.B O The O authors O are O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC1310400 O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG 81771436 O 81501148 B-AWARD U1502228 B-AWARD 81801319 B-AWARD 81601164 B-AWARD Shanghai B-ORG Municipal I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG 2017ZZ02021 O Municipal B-ORG Human I-ORG Resources I-ORG Development I-ORG Program I-ORG for I-ORG Outstanding I-ORG Young I-ORG Talents I-ORG in I-ORG Medical I-ORG and I-ORG Health I-ORG Sciences I-ORG in I-ORG Shanghai I-ORG 2017YQ013 O Shanghai B-ORG Key I-ORG Laboratory I-ORG of I-ORG Psychotic I-ORG Disorders I-ORG 13DZ2260500 O Program B-ORG of I-ORG Shanghai I-ORG Academic I-ORG Research I-ORG Leader I-ORG 17XD1403300 O Clinical B-ORG Research I-ORG Center I-ORG of I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG School I-ORG of I-ORG Medicine I-ORG DLY201818 O Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Committee I-ORG 18411961200 O Shanghai B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG 2018SHZDZX05 O and O Shanghai B-ORG Clinical I-ORG Research I-ORG Center I-ORG for I-ORG Mental I-ORG Health I-ORG 19MC1911100 O The O funders O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O study O was O funded O by O Major B-ORG science I-ORG and I-ORG technology I-ORG projects I-ORG of I-ORG Zhejiang I-ORG province I-ORG 2014C03032 O Key B-ORG research I-ORG project I-ORG of I-ORG traditional I-ORG Chinese I-ORG medicine I-ORG science I-ORG and I-ORG technology I-ORG plan I-ORG in I-ORG Zhejiang I-ORG Province I-ORG 2015ZZ007 O and O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0113500 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O the O Breast B-ORG Cancer I-ORG Research I-ORG Foundation I-ORG BCRF-17-161 O Morgan O Welch O Inflammatory O Breast O Cancer O Research O Program O and O Clinic O State O of O Texas O Rare O and O Aggressive O Breast O Cancer O Research O Program O National B-ORG Institutes I-ORG of I-ORG Health I-ORG through O award O numbers O 1R01CA205043-01A1 B-AWARD N.T.U O and O NIH O GM123252 B-AWARD Cancer B-ORG Prevention I-ORG and I-ORG Research I-ORG Institute I-ORG of I-ORG Texas I-ORG award O numbers O RP160657 B-AWARD and O RP180880 B-AWARD and O Welch B-ORG Foundation I-ORG award O number O F-1390 B-AWARD K.N.D O This O research O was O funded O by O Postgraduate O Research O O Practice O Innovation O Program O of O Jiangsu O Province O grant O number O KYCX19_1717 O Jiangsu B-ORG Agriculture I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Fund O grant O number O CX(18)2028 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51703148 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017M611901 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2232019D3-07 O This O work O was O also O supported O by O 111 O Project O and O Initial O Research O Funds O for O Young O Teachers O of O Donghua O University O This O research O was O supported O by O the O Special B-ORG Funding I-ORG of I-ORG the I-ORG ‘Belt I-ORG and I-ORG Road’ I-ORG International I-ORG Cooperation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG under O grant O 2015C04005 B-AWARD and O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG grant O Z741020001 B-AWARD Partly O this O research O was O supported O by O the O Center O for O Integrated O Nanotechnologies O an O Office O of O the O Science O User O Facility O operated O for O the O US O Department O of O Energy O DOE O Office O of O Science O by O Los B-ORG Alamos I-ORG National I-ORG Laboratory I-ORG Contract O DE-AC52-06NA25396 B-AWARD and O Sandia B-ORG National I-ORG Laboratories I-ORG Contract O DE-NA-0003525 B-AWARD The O Project O Sponsored O by O the O Scientific O Research O Foundation O for O the O Returned B-ORG Overseas I-ORG Chinese I-ORG Scholars I-ORG State I-ORG Education I-ORG Ministry I-ORG No. O 2015-1098 B-AWARD The O work O was O also O supported O by O Chongqing B-ORG Key I-ORG Research I-ORG Project I-ORG of I-ORG Basic I-ORG Science I-ORG I-ORG Frontier I-ORG Technology I-ORG No. O cstc2017jcyjBX0012 B-AWARD Foundation B-ORG Project I-ORG of I-ORG Chongqing I-ORG Normal I-ORG University I-ORG No. O 14XYY020 B-AWARD Chongqing B-ORG General I-ORG Research I-ORG Program I-ORG of I-ORG Basic I-ORG Research I-ORG and I-ORG Frontier I-ORG Technology I-ORG No. O cstc2015jcyjA10054 B-AWARD and O Chongqing B-ORG Normal I-ORG University I-ORG Postgraduate's I-ORG Research I-ORG and I-ORG Innovation I-ORG Project I-ORG No. O YKC17004 B-AWARD China O This O research O was O supported O by O Grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21476014 O National B-ORG Science I-ORG I-ORG Technology I-ORG Pillar I-ORG Program I-ORG of I-ORG China I-ORG 2015BAD15B09 O Higher B-ORG Education I-ORG and I-ORG Highquality I-ORG and I-ORG Worldclass I-ORG Universities I-ORG BUCTYLKXJ03 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG XK1701 O This O research O was O funded O by O the O Grant-in-Aid B-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Joint I-ORG International I-ORG Research I-ORG Fostering O Joint O International O Research O B)) O No. O 18KK0194 B-AWARD and O the O Grant-in-Aid B-ORG for I-ORG Scientific I-ORG Research I-ORG C) O Nos O 21K04985 B-AWARD and O 22K06164 B-AWARD from O the O Japan O Society O for O the O Promotion O of O Science O and O by O the O Grant-in-Aid B-ORG for I-ORG Transformative I-ORG Research I-ORG Areas I-ORG A) O “Progressive O condensed O matter O physics O inspired O by O hyper-ordered O structures” O No. O 20H05883 B-AWARD from O the O Ministry O of O Education O Culture O Sports O Science O and O Technology O MEXT O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61801164 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Tianjin I-ORG City I-ORG No. O 18JCQNJC01700 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG No. O F2019202387 B-AWARD and O Foundation O of O Hebei O Educational O committee O No. O QN2018092 O This O work O was O supported O by O the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O Numbers O 2013AA102803 B-AWARD 2014AA021301 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Numbers O 31770094 B-AWARD 91731310 B-AWARD and O 31771384 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Research I-ORG Program I-ORG of I-ORG Shanghai I-ORG Grant O Number O 18391901800 B-AWARD and O the O Open O Research O Funds O of O the O State O Key O Laboratory O of O Genetic O Engineering O Fudan O University O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.31560401 O for O designing O of O the O study O including O high-throughput O sequencing O and O SNP O marker O design O The O funding O was O also O for O writing O the O manuscript O The O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG ASTIP O in O China O and O Modern B-ORG Agricultural I-ORG Industry I-ORG Technology I-ORG System I-ORG CARS-17-GW-04 O played O roles O for O data O collection O of O the O field O trail O experiments O and O phenotype O screening O analysis O the O data O and O interpretation O of O these O data O This O work O was O supported O by O the O Traditional B-ORG Chinese I-ORG Medicine I-ORG Bureau I-ORG of I-ORG Guangdong I-ORG Province I-ORG grant O number O 20201162 B-AWARD Construction B-ORG of I-ORG National I-ORG Specialized I-ORG Diagnosis I-ORG and I-ORG Treatment I-ORG Center I-ORG of I-ORG Regional I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG grant O number O 0103020802 B-AWARD and O Pilot B-ORG Construction I-ORG of I-ORG Clinical I-ORG Collaboration I-ORG between I-ORG Chinese I-ORG and I-ORG Western I-ORG Medicine I-ORG in I-ORG Major I-ORG and I-ORG Refractory I-ORG Disease I-ORG grant O number O 0103020603 B-AWARD This O work O was O supported O by O The B-ORG Outstanding I-ORG Young I-ORG Talent I-ORG Project I-ORG of I-ORG the I-ORG Second I-ORG Affiliated I-ORG Hospital I-ORG of I-ORG Chongqing I-ORG Medical I-ORG University I-ORG grant O no. O 2014-43 B-AWARD and O the B-ORG Research I-ORG Projects I-ORG of I-ORG the I-ORG Health I-ORG Bureau I-ORG in I-ORG Chongqing I-ORG grant O no. O 2010-2-153 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O nos O 31300137 B-AWARD and O 81401423 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O a O post-doctoral O grant O from O the O Basque O Government O Research O Personnel O Improvement O Program O by O theDepartment O of I-ORG Education I-ORG Language I-ORG Policy I-ORG and I-ORG Culture O POS_2013_1_130,POS_2014_2_49to O I.M O andGeorgia O Tech-Atlanta I-ORG Zoo I-ORG collaborative I-ORG grant I-ORG National I-ORG Science I-ORG Foundation(BCS-1317195to O S.V.Y O and O theNational O Institutes I-ORG of I-ORG Health(R21MH102677and1R01MH103517-01A1to O S.V.Y O Funding O to O pay O the O Open O Access O publication O charges O for O this O article O was O provided O by O theNational O Institute O of O Healthgrant O 1R01MH102677-01A1 O Funding O was O provided O by O Agencia B-ORG Nacional I-ORG de I-ORG Promoción I-ORG Científica I-ORG y I-ORG Técnica I-ORG PICT O 2014-0850 I-AWARD to O Horacio O Heras O Universidad B-ORG Nacional I-ORG de I-ORG La I-ORG Plata I-ORG PID O 11/M197 I-AWARD to O Horacio O Heras O the O National B-ORG Science I-ORG Foundation I-ORG IOS-1025886 O to O Enrique O Caviedes-Vidal O Consejo B-ORG de I-ORG Investigaciones I-ORG Científicas I-ORG y I-ORG Técnicas I-ORG CONICET O PIP834 I-AWARD to O Enrique O Caviedes-Vidal O and O Universidad B-ORG Nacional I-ORG de I-ORG San I-ORG Luis I-ORG CyT O 2-0814 I-AWARD to O Enrique O Caviedes-Vidal O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 31801686 O the O Outstanding B-ORG Scientist I-ORG of I-ORG Beijing I-ORG Academy I-ORG of I-ORG Agriculture I-ORG and I-ORG Forestry I-ORG Sciences I-ORG JKZX202204 O the O Promotion B-ORG and I-ORG Innovation I-ORG Foundation I-ORG of I-ORG Beijing I-ORG Academy I-ORG of I-ORG Agriculture I-ORG and I-ORG Forestry I-ORG Sciences I-ORG KJCX20190406 O and O the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG of I-ORG MOF I-ORG and I-ORG MARA I-ORG CARS-29 O This O work O was O funded O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0503100 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31501810 O and O 31601343 B-AWARD and O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O No. O LQ14C060001 B-AWARD This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 61871315 B-AWARD in O part O by O Technology O Program O of O Shenzhen O grant O number O JCYJ20170816100722642 O in O part O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O China O grant O number O 2018A030313429 B-AWARD and O in O part O by O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG under O Grant O 2015M580849 B-AWARD The O APC O was O funded O by O 61871315 O This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.41471072 B-AWARD and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No.2017YFC0405303 B-AWARD Also O thanks O to O the O first O class O General O Financial O Grant O from O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No.2017M620023 B-AWARD This O research O was O supported O by O grants O to O the O senior O author O JKT O from O the O following O sources O Air B-ORG Force I-ORG Office I-ORG of I-ORG Scientific I-ORG Research I-ORG USA O FA9550-18-1-0054 O https://www.wpafb.af.mil/afrl/afosr O Office B-ORG of I-ORG Naval I-ORG Research I-ORG USA O N00178-16-P-0087 O https://www.onr.navy.mil O The O Canada B-ORG Research I-ORG Chairs I-ORG Program O 950-231659 O http://www.chairs-chaires.gc.ca/home-accueil-eng.aspx O and O Natural B-ORG Sciences I-ORG and I-ORG Engineering I-ORG Research I-ORG Council I-ORG of I-ORG Canada I-ORG RGPIN-2016-05352 O https://www.canada.ca/en/science-engineering-research.html O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81873691 O 81500768 B-AWARD and O 81770975 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant I-ORG 2018T110914 O and O 2018M633245 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG China I-ORG 201803010110 O and O 201605030003 B-AWARD and O the B-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG 2016A020215049 O This O research O was O funded O by O The O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC1202100 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO.31270683 O and O the O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 71471102 B-AWARD Major B-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG in I-ORG Hubei I-ORG Province I-ORG of I-ORG China I-ORG Grant O No. O 2020AEA012 B-AWARD and O Yichang B-ORG University I-ORG Applied I-ORG Basic I-ORG Research I-ORG Project I-ORG in I-ORG China I-ORG Grant O No. O A17-302-a13 B-AWARD This O project O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31970888 B-AWARD Key O Projects O in O the O National O Science O O Technology O Pillar O Program O in O the O Thirteenth O Five-year O Plan O Period O Grant O No. O 2018ZX10731101-001-010 O and O 2018ZX10731101-002-003 O National B-ORG Postdoctoral I-ORG Program I-ORG for I-ORG Innovative I-ORG Talents I-ORG No. O BX20180124 B-AWARD and O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2018M641786 B-AWARD This O study O was O supported O by O the O Science B-ORG Technology I-ORG I-ORG Innovation I-ORG Commission I-ORG of I-ORG Shenzhen I-ORG Municipality I-ORG No. O JCYJ20180305180540801 B-AWARD the B-ORG Key I-ORG Scientific I-ORG Research I-ORG Project I-ORG for I-ORG Young I-ORG People I-ORG in I-ORG Shenzhen I-ORG Municipal I-ORG People's I-ORG Hospital I-ORG No. O SYKYPY201931 B-AWARD and O the B-ORG General I-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81572486 B-AWARD The O authors O thank O the O Japan B-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG #SP13031 O and O the O U.S O National B-ORG Science I-ORG Foundation I-ORG #OISE-1308822 O for O making O this O collaboration O possible O WL O and O RH-N O gratefully O acknowledge O funding O from O the O U.S O Office B-ORG of I-ORG Naval I-ORG Research I-ORG #N00014-12-1-0588 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81903867 B-AWARD 81541158 I-AWARD 81772281 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG Nos O ZR2018BH046 B-AWARD ZR2018QH005 O A O Project O of O Shandong O Province O Higher O Educational O Science O and O Technology O Program O under O Grant O No. O J15LM51 O Shandong O Science O and O Technology O Committee O No. O ZR2019MH022 O Yantai O Science O and O Technology O Committee O No. O 2018XSCC051 O and O Shandong B-ORG Province I-ORG Taishan I-ORG Scholar I-ORG Project I-ORG No. O ts201712067 B-AWARD This O work O is O supported O by O the O Interdisciplinary B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangxi I-ORG University I-ORG Grant O No. O 2022JCC014 B-AWARD Guangdong B-ORG Guangxi I-ORG joint I-ORG Science I-ORG Key I-ORG Foundation I-ORG Grants O No. O 2021GXNSFDA076001 B-AWARD Guangxi B-ORG Major I-ORG projects I-ORG of I-ORG science I-ORG and I-ORG technology I-ORG Grants O No. O 2020AA21077007 B-AWARD and O 2020AA24002AA B-AWARD and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grants O No. O 62275269 B-AWARD 12272407 B-AWARD and O 62275271 B-AWARD The O authors O are O thankful O to O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51865017 B-AWARD Sichuan B-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Engineering I-ORG No. O 2017RCL64 O Opening B-ORG Project I-ORG of I-ORG Material I-ORG Corrosion I-ORG and I-ORG Protection I-ORG Key I-ORG Laboratory I-ORG of I-ORG Sichuan I-ORG Province I-ORG No. O 2016CL01 O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Solid I-ORG Lubrication I-ORG No. O LSL-1705 O Science O and O Technology O Planning O Project O of O Sichuan O Province O No. O 2016JZ0032 O Doctoral O Scientific O Research O Foundation O of O Jiangxi O University O of O Science O and O Technology(No O jxxjbs19004 O This O work O was O supported O in O part O by O grant O UL1TR001105 B-AWARD from O the O National O Center O for O Advancing O Translational O Science O https://ncats.nih.gov O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH,https://www.nih.gov O in O part O by O the O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health I-ORG https://www.nimh.nih.gov/index.shtml O of O the O National O Institutes O of O Health O under O Award O Number O R25MH101078 B-AWARD and O in O part O by O NIH O grant O 1K99CA20452201 B-AWARD to O CC. O The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O Center O for O Translational O Medicine O The O University O of O Texas O Southwestern O Medical O Center O and O its O affiliated O academic O and O health O care O centers O the O National B-ORG Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences O or O the O National O Institutes O of O Health O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O National B-ORG Social I-ORG Science I-ORG Foundation I-ORG for I-ORG Education I-ORG of I-ORG China I-ORG BBA140049 O the O Humanities B-ORG and I-ORG Social I-ORG Science I-ORG Research I-ORG Base I-ORG project I-ORG of I-ORG Chongqing I-ORG in I-ORG SWU I-ORG 14SK13033 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG SWU1609320 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81300505 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG 17ZR1422000 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81971383 O This O work O is O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO. O 51274150 O Key B-ORG Scientific I-ORG and I-ORG Technological I-ORG Support I-ORG Projects I-ORG of I-ORG Tianjin I-ORG Key I-ORG R&D I-ORG Program(NO O 18YFZCGX00930 O and O Tianjin B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG NO. O 18YFJLCG00060 O The O authors O express O their O heartfelt O thanks O to O the O above O fund's O support O This O research O was O funded O by O National O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 61705204 O 61705206 B-AWARD China O Postdoctoral I-ORG Science I-ORG Foundation O grant O number O 2019M653486 O 2019M651998 B-AWARD Innovation O and O Development O Foundation O of O China O Academy O of O Engineering O Physics O grant O number O CX20200021 O and O Natural O Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province O grant O number O BK20190229 O This O work O was O financially O supported O by O Fundação B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG Tecnologia I-ORG through O the O projects O PTDC/BIA-PRO/098882/2008 B-AWARD Sofia O R. O Pauleta O and O PTDC/BIA-PRO/109796/2009 B-AWARD Sofia O R. O Pauleta O and O the O scholarship O SFRH/BD/87898/2012 B-AWARD Cíntia O Carreira O This O work O was O also O supported O by O the O Unidade O de O Ciências O Biomoleculares O Aplicadas-UCIBIO O which O is O financed O by O national O funds O from O FCT/MEC B-ORG UID/Multi/04378/2013 O and O co-financed O by O the O ERDF B-ORG under O the O PT2020 O Partnership O Agreement O POCI-01-0145-FEDER-007728 O The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O in O part O by O Servier O Pharmaceuticals O The O collection O of O cancer O incidence O data O used O in O this O study O was O supported O by O the O California B-ORG Department I-ORG of I-ORG Public I-ORG Health I-ORG pursuant I-ORG to I-ORG California I-ORG Health I-ORG and I-ORG Safety I-ORG Code I-ORG Section I-ORG 103885 B-AWARD Centers B-ORG for I-ORG Disease I-ORG Control I-ORG and I-ORG Prevention’s I-ORG National I-ORG Program I-ORG of I-ORG Cancer I-ORG Registries O under O cooperative O agreement O 5NU58DP006344 B-AWARD the O National B-ORG Cancer I-ORG Institute’s I-ORG Surveillance I-ORG Epidemiology I-ORG and I-ORG End I-ORG Results I-ORG Program O under O contract O HHSN261201800032I B-AWARD awarded O to O the O University B-ORG of I-ORG California I-ORG San I-ORG Francisco O contract O HHSN261201800015I B-AWARD awarded O to O the O University B-ORG of I-ORG Southern I-ORG California O and O contract O HHSN261201800009I B-AWARD awarded O to O the O Public O Health O Institute O This O work O was O supported O in O part O by, O the O Ontario B-ORG Preclinical I-ORG Imaging I-ORG Consortium I-ORG OPIC I-ORG grant O RE03-51 B-AWARD Ontario O Research O Foundation O and O the O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG MOP-80203 O I-AWARD MOP-287694 O and O by O the O Molecular B-ORG Function I-ORG and I-ORG Imaging I-ORG Heart I-ORG and I-ORG Stroke I-ORG Foundation I-ORG of I-ORG Ontario I-ORG Program I-ORG Grant O #PRG6242 O BI O was O a O doctoral O student O co-supervised O by O JDS O and O RSB O and O supported O by O the O PhD O scholarship O from O the O University O of O Ottawa's O Faculty O of O Medicine O Endowed O Funds O for O Cardiac O Graduate O Research O and O the O UOHI O Foundation O RSB O is O a O Career O Investigator O supported O by O the O Heart O and O Stroke O Foundation O of O Ontario O HFSO O the O University O of O Ottawa O Heart O Institute O UOHI O Vered O Chair O in O Cardiology O and O Tier O 1 O University O of O Ottawa O Chair O in O Cardiovascular O Research O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31901881 O 31871979 B-AWARD National B-ORG Key I-ORG R&D I-ORG Plan I-ORG in I-ORG China I-ORG 2017YFD0201700 O 2017YFD0200900 B-AWARD 2016YFD0300700 B-AWARD State B-ORG Modern I-ORG Agricultural I-ORG Industry I-ORG Technology I-ORG System I-ORG CARS-22-G-18 O The O funding O organizations O played O no O role O in O the O design O of O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O funded O by O the O National B-ORG Important I-ORG Scientific I-ORG I-ORG Technological I-ORG Project I-ORG 2018ZX10101002-002 O National B-ORG Health I-ORG Commission I-ORG Special I-ORG Project I-ORG for I-ORG Lancang-Mekong I-ORG Cooperation I-ORG in I-ORG 2017 I-ORG No. O 2020399 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG No. O 18ZR1443400 B-AWARD and O National B-ORG Institutes I-ORG of I-ORG Health/National I-ORG Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases I-ORG U19 I-ORG project I-ORG No. O U19AI129386 B-AWARD This O work O was O supported O by O the O Opening O Foundation O of O State O Key O Laboratory O of O Optical O Technologies O on O Nano-Fabrication O and O Micro-Engineering O Institute O of O Optics O and O Electronics O Chinese O Academy O of O Sciences O 973 B-ORG Program I-ORG of I-ORG China I-ORG 2013CBA01700 O Sichuan B-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG 16ZA0047 O Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG 2018JY0439 O 2018JY0616 B-AWARD The O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG lzujbky-2018-13 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81803188 O Gansu B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 1606RJYA270 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O nos O 21971109 B-AWARD and O 21834004 B-AWARD Jiangsu O Youth O Fund O Grant O no. O BK20180337 O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O no. O 14380151 B-AWARD This O work O was O also O supported O by O the O Program O for O Innovative O Talents O and O Entrepreneur O in O Jiangsu O No. O 133181 O Shenzhen B-ORG International I-ORG Cooperation I-ORG Research I-ORG Project I-ORG No. O GJHZ20180930090602235 B-AWARD and O Nanjing O Science O and O Technology O Innovation O Project O for O Oversea O Scholars’ O Merit O Funding O No. O 133170 O This O research O was O supported O by O the O Shanxi B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Projects I-ORG 20140323001 O Shanxi B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG 201601D102042 O and O Shanxi B-ORG Provincial I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Research I-ORG Projects I-ORG 2015101 O The O O’Neill O laboratory O acknowledges O grant O support O from O the O European B-ORG Research I-ORG Council I-ORG Horizon O 2020 O Metabinnate O 834370 O the O Wellcome B-ORG Trust I-ORG 205455 O and O Science B-ORG Foundation I-ORG Ireland I-ORG 19/FFP/6507 O This O study O was O supported O by O the O General B-ORG Project I-ORG of I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Henan I-ORG Province I-ORG 222300420568 O Key B-ORG Medical I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Henan I-ORG Province I-ORG SBGJ202101014 O Major B-ORG Scientific I-ORG Research I-ORG Projects I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG in I-ORG Henan I-ORG Province I-ORG 20-21ZYZD14 O and O Cultivation B-ORG of I-ORG Young I-ORG and I-ORG Middle-aged I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Leading I-ORG Talents I-ORG in I-ORG Henan I-ORG Province I-ORG YXKC2020015 O This O work O was O supported O by O grants O from O the O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III I-ORG Madrid O Spain O PI17/02256 B-AWARD and O PI20/01845 B-AWARD from O the O Consejería B-ORG de I-ORG Salud I-ORG y I-ORG Familia I-ORG de I-ORG la I-ORG Junta I-ORG de I-ORG Andalucía I-ORG PY20/01282 O and O from O the O Dietmar O Hopp O Foundation O and O the O German B-ORG Ministry I-ORG of I-ORG Education I-ORG and I-ORG Science I-ORG BMBF O CLIOMMICS O 01ZX1309 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31972994 O the O National B-ORG Beef I-ORG and I-ORG Yak I-ORG Industrial I-ORG Technology I-ORG System I-ORG CARS-37 O the O Special B-ORG Project I-ORG for I-ORG the I-ORG Central I-ORG Government I-ORG to I-ORG Guide I-ORG Local I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG 2060404-51301 O the O Science B-ORG and I-ORG Technology I-ORG Special I-ORG Project I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Agriculture I-ORG and I-ORG Rural I-ORG Affairs I-ORG 19211178 O and O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 2022NY-050 O 2022ZDLNY01-01 B-AWARD This O work O was O supported O in O part O by O grants O from O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Taiwan I-ORG MOST O 103-2314-B-016 I-AWARD 018 I-AWARD MY2 I-AWARD to O HC O Chen O Tri-Service B-ORG General I-ORG Hospital I-ORG TSGH-C105-008 O to O HC O Chen O National B-ORG Defense I-ORG Medical I-ORG Research I-ORG grants O Taiwan O ROC O MAB-104-058 O and I-AWARD MAB-105-019 I-AWARD to O HC O Chen O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O material O is O based O upon O work O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG MCB1715494 O to O A.M.A.-B O and O the O Graduate B-ORG Research I-ORG Fellowship I-ORG Program I-ORG under O Grant O No. O DGE-1747453 B-AWARD to O C.D O and O the O Welcome B-ORG Trust I-ORG Seed I-ORG Award I-ORG under O Grant O No. O 214930/Z/18/Z B-AWARD to O Y.-J.H O This O work O was O funded O by O the O National B-ORG Key I-ORG Plan I-ORG for I-ORG Scientific I-ORG Research I-ORG and I-ORG Development I-ORG of I-ORG China I-ORG 2017YFD0200406 O 2016YFC1200603 I-AWARD 2017YFD0200904 O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG CAS O XDB11040000 O XDB11050000 O Ministry B-ORG of I-ORG Agriculture I-ORG transgenic I-ORG major I-ORG projects I-ORG 2016ZX08010001 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 91540116 I-AWARD 31772162 I-AWARD 31472051 I-AWARD 31471782 O and O the O Open B-ORG Research I-ORG Fund I-ORG Program I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Integrated I-ORG Management I-ORG of I-ORG Pest I-ORG Insects I-ORG and I-ORG Rodents I-ORG Chinese O IPM I-AWARD 1801 I-AWARD Chinese I-AWARD IPM I-AWARD 1605 O This O study O was O supported O by O the O Inner B-ORG Mongolia I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Foundation I-ORG 20160415 O Inner B-ORG Mongolia I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Guide I-ORG Fund I-ORG CX2016011 O and O CX2017008 B-AWARD Inner B-ORG Mongolia I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Foundation I-ORG NK2016ZD1024 O Inner B-ORG Mongolia I-ORG Industrial I-ORG Innovation I-ORG Talent I-ORG Team I-ORG 20130430 O 20171903 B-AWARD Shenhua B-ORG Shendong I-ORG Group I-ORG Science I-ORG and I-ORG Technology I-ORG Foundation I-ORG CSIE-HT20162190 O Ordos B-ORG Science I-ORG and I-ORG Technology I-ORG Foundation I-ORG 20161220 O and O Ordos B-ORG High-Level I-ORG Talent I-ORG Innovation I-ORG and I-ORG Venture I-ORG Base I-ORG Foundation I-ORG 2016121901 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The B-ORG Mega-projects I-ORG of I-ORG National I-ORG Science I-ORG Research I-ORG for I-ORG the I-ORG 13th I-ORG Five-Year I-ORG Plan I-ORG 2017ZX10201101 O the B-ORG Non-profit I-ORG Central I-ORG Research I-ORG Institute I-ORG Fund I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences(2018PT31042 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 81871637 O jointly O funded O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O partly O supported O by O The B-ORG National I-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61300078 B-AWARD and O The B-ORG Importation I-ORG and I-ORG Development I-ORG of I-ORG High-Caliber I-ORG Talents I-ORG Project I-ORG of I-ORG Beijing I-ORG Municipal I-ORG Institutions I-ORG CIT&TCD20130320 O CIT&TCD201504039 O and O Funding B-ORG Project I-ORG for I-ORG Academic I-ORG Human I-ORG Resources I-ORG Development I-ORG in I-ORG Beijing I-ORG Union I-ORG University I-ORG Zk80201403 O Rk100201510 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31601993 B-AWARD the O earmarked B-ORG fund I-ORG for I-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-34 O and O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG ASTIP-IAS14 O The O present O study O was O funded O mainly O by O grant O MŠMT B-ORG LH14053 B-AWARD Institutional O support O was O covered O by O RVO B-ORG 67985823 B-AWARD The O work O of O ŠB O was O partly O funded O by O Deutsche B-ORG Forschungsgemeinschaft I-ORG DFG-RTG O 1253/2 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81772625 B-AWARD and O 81772598 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017A030311006 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG China I-ORG 18ykpy36 O and O the O Guangdong B-ORG Key I-ORG Laboratory I-ORG of I-ORG Liver I-ORG Disease I-ORG Research I-ORG GS2017101001 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 22006111 B-AWARD and O 21806142 B-AWARD Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O LY20B070002 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2019M661796 B-AWARD and O Taizhou B-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG Grant O No. O 22hbb03 B-AWARD Jin-Ying O Gou O thanks O the O financial O support O from O The B-ORG Program I-ORG for I-ORG Professor I-ORG of I-ORG Special I-ORG Appointment I-ORG Eastern I-ORG Scholar I-ORG at O Shanghai O Institutions O of O Higher O Learning O SHH1322012 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31470386 O and O the O Recruitment B-ORG Program I-ORG of I-ORG Global I-ORG Expects I-ORG China I-ORG D1110013 O The O present O study O was O financially O supported O by O grants O from O the O Earmarked O Fund O for O Modern B-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG of I-ORG China I-ORG CARS-25 O the O Science B-ORG and I-ORG Technological I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 2015KTTSNY03-04 O the O Scientific B-ORG Startup I-ORG Foundation I-ORG for I-ORG Doctors I-ORG of I-ORG Northwest I-ORG A&F I-ORG University I-ORG Z109021604 O the O Basal B-ORG Research I-ORG Foundation I-ORG of I-ORG Northwest I-ORG A&F I-ORG University I-ORG Z109021612 O and O the O Key B-ORG Project I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 2017ZDXM-NY-025 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Project O supported O by O the O National B-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG 81141019 O Hainan B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Key I-ORG Program I-ORG ZDXM2014062 O Hainan B-ORG Province I-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG 813227 O Hainan B-ORG Province I-ORG Medical I-ORG Scientific I-ORG Research I-ORG Subject I-ORG Qiong2012PT-73 O Binzhou B-ORG Medical I-ORG College I-ORG Scientific I-ORG Plan I-ORG and I-ORG Research I-ORG Foundation I-ORG BY2015KJ17 O This O work O is O supported O in O part O by O the O Chinese B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O No. O 61472082 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG of I-ORG China I-ORG Grant O No. O 2014J01220 B-AWARD Scientific B-ORG Research I-ORG Innovation I-ORG Team I-ORG Construction I-ORG Program I-ORG of I-ORG Fujian I-ORG Normal I-ORG University I-ORG Grant O No. O IRTL1702 B-AWARD and O the O US O National O Science O Foundation O Grant O No. O IIS-1552860 O The O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81402693;http://www.nsfc.gov.cn/publish/portal1 B-AWARD Shanghai B-ORG Pujiang I-ORG Program I-ORG Grant O No. O 14PJC012;http://www.stcsm.gov.cn/english B-AWARD and O Award O from O Shanghai B-ORG Municipal I-ORG Health I-ORG Bureau I-ORG Grant O No. O 15GWZK0402;http://www.mlghj.com B-AWARD The O funding O was O received O by O LT. O The O funding O received O from O the O National O Natural O Science O Foundation O of O China O and O Shanghai O Pujiang O Program O supported O the O study O design O data O collection O and O analysis O The O funding O received O from O the O Award O of O Shanghai O Municipal O Health O Bureau O contributed O to O the O manuscript O preparation O and O publication O This O study O was O supported O by O grants O from O the O Key B-ORG Medical I-ORG Disciplines I-ORG Building I-ORG Project I-ORG of I-ORG Shenzhen I-ORG grant O number O SZXJ2017005 B-AWARD the O Sanming B-ORG Project I-ORG of I-ORG Medicine I-ORG in I-ORG Shenzhen I-ORG grant O number O SZSM201512030 B-AWARD the O Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Project O grant O numbers O JCYJ20170303155012371 B-AWARD and O JCYJ20170816170527583 B-AWARD and O the O Guangdong B-ORG Medical I-ORG Research I-ORG Fund I-ORG grant O number O A2017213 B-AWARD This O work O was O supported O partly O by O funding O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O no. O 81600434 B-AWARD Jiangsu B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O no. O BK20160572 B-AWARD and I-AWARD BK20170358 O and O Jiangsu B-ORG Provincial I-ORG Medical I-ORG Youth I-ORG Talent I-ORG Grant O no. O QNRC2016514 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81602673 O for O pathologic O slides O preparing O IHC O staining O and O follow-up O of O patients O Key B-ORG Laboratory I-ORG of I-ORG Malignant I-ORG Tumor I-ORG Molecular I-ORG Mechanism I-ORG and I-ORG Translational I-ORG Medicine I-ORG of I-ORG Guangzhou I-ORG Bureau I-ORG of I-ORG Science I-ORG and I-ORG Information I-ORG Technology I-ORG [2013]163 O for O data O collection O and O dataset O build O up O Key B-ORG Laboratory I-ORG of I-ORG Malignant I-ORG Tumor I-ORG Gene I-ORG Regulation I-ORG and I-ORG Target I-ORG Therapy I-ORG of I-ORG Guangdong I-ORG Higher I-ORG Education I-ORG Institutes I-ORG KLB09001 O for O data O analysis O This O work O was O funded O by O Howard B-ORG Hughes I-ORG Medical I-ORG Institute I-ORG HHMI O – O Gates O International O Research O Scholar O award O to O FO O OPP1175877 O a O Bill B-ORG I-ORG Melinda I-ORG Gates I-ORG Foundation I-ORG Grant O OPP1177156 O and O the O Innovative B-ORG Vector I-ORG Control I-ORG Consortium I-ORG IVCC O Project O No: B-AWARD 43 I-AWARD – O Mating O Swarms O EK O was O also O supported O through O a O Consortium B-ORG for I-ORG Advanced I-ORG Research I-ORG Training I-ORG in I-ORG Africa I-ORG CARTA O CARTA O is O jointly O led O by O the O African O Population O and O Health O Research O Center O and O the O University O of O the O Witwatersrand O and O funded O by O the O Carnegie O Corporation O of O New O York O Grant O No–B O 8606.R02 O Sida O Grant O No: O 54100113 O the O DELTAS O Africa O Initiative O Grant O No: O 107768/Z/15/Z B-AWARD and O Deutscher O Akademischer O Austauschdienst O DAAD O The O DELTAS O Africa O Initiative O is O an O independent O funding O scheme O of O the O African O Academy O of O Sciences O AAS)’s O Alliance O for O Accelerating O Excellence O in O Science O in O Africa O AESA O and O supported O by O the O New O Partnership O for O Africa’s O Development O Planning O and O Coordinating O Agency O NEPAD O Agency O with O funding O from O the O Wellcome O Trust O UK) O and O the O UK O government O FO O was O also O funded O by O Wellcome B-ORG Trust I-ORG Intermediate I-ORG Fellowship I-ORG in I-ORG Public I-ORG Health I-ORG and I-ORG Tropical I-ORG Medicine I-ORG Grant O Number O WT102350/Z/13 B-AWARD AM O was O also O funded O by O Wellcome B-ORG Trust I-ORG Masters I-ORG Fellowship I-ORG in I-ORG Public I-ORG Health I-ORG and I-ORG Tropical I-ORG Medicine I-ORG and O the O Association O of O Great O Britain O and O Ireland O Grant O Number O 106356/Z/14/Z B-AWARD MC O was O supported O by O the O DST/NRF B-ORG South I-ORG African I-ORG Research I-ORG Chairs I-ORG Initiative I-ORG Grant O No: O 64763 B-AWARD This O work O was O supported O by O ZhiFei B-ORG Disease I-ORG Prevention I-ORG and I-ORG Control I-ORG Technology I-ORG Research I-ORG Fund I-ORG Project I-ORG No. O LYH2017-08 B-AWARD to O YF, O Open B-ORG Research I-ORG Fund I-ORG of I-ORG Shandong I-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG Of I-ORG Infectious I-ORG Disease I-ORG Control I-ORG and I-ORG Prevention I-ORG Shandong I-ORG Center I-ORG for I-ORG Disease I-ORG Control I-ORG and I-ORG Prevention I-ORG No. O 2017KEYLAB01 B-AWARD to O YG, O Shandong B-ORG Medical I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Programs I-ORG No. O 2018WS309 B-AWARD to O YF, O Science B-ORG and I-ORG Technology I-ORG Project I-ORG for I-ORG the I-ORG Universities I-ORG of I-ORG Shandong I-ORG Province I-ORG No. O J18KB171 B-AWARD to O YG, O Discipline B-ORG Talent I-ORG Team I-ORG Cultivation I-ORG Program I-ORG of I-ORG Shandong I-ORG Women’s I-ORG University I-ORG No. O 1904 B-AWARD to O YG, O and O Shandong B-ORG Women’s I-ORG University I-ORG High I-ORG level I-ORG scientific I-ORG research I-ORG project I-ORG Cultivation I-ORG Fund I-ORG No. O 2019GSPGJ07 B-AWARD to O YG. O This O work O is O financially O supported O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC2000600 O and O Finance B-ORG Department I-ORG of I-ORG the I-ORG State I-ORG Administration I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG GZY-GCS-2018-011 O and O the O Wushu B-ORG Research I-ORG Institute I-ORG of I-ORG the I-ORG General I-ORG Administration I-ORG of I-ORG Sport I-ORG of I-ORG China I-ORG WSH2018A004 O This O paper O was O funded O in O part O by O the O Jonas O Children’s O Vision O Care O and O Bernard O O Shirlee O Brown O Glaucoma O Laboratory O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG P30EY019007 O R01EY018213 B-AWARD R01EY024698 B-AWARD R01EY026682 B-AWARD R21AG050437 B-AWARD R24EY027285 B-AWARD National B-ORG Cancer I-ORG Institute I-ORG Core O 5P30CA013696 O Foundation B-ORG Fighting I-ORG Blindness I-ORG TA-NMT-0116-0692-COLU O the O Research O to O Prevent O Blindness O RPB O Physician-Scientist O Award O and O unrestricted O funds O from O RPB O New O York O NY, O USA O S.H.T O is O a O member O of O the O RD-CURE O Consortium O and O is O supported O by O Kobi O and O Nancy O Karp O the O Crowley O Family O Fund O the O Rosenbaum O Family O Foundation O the O Tistou O and O Charlotte O Kerstan O Foundation O the O Schneeweiss O Stem O Cell O Fund O New O York O State O C029572 O and O the O Gebroe O Family O Foundation O This O research O was O funded O by O Key B-ORG research I-ORG and I-ORG development I-ORG plan I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology O grant O number O 2020YFC2005003 B-AWARD China B-ORG natural I-ORG science I-ORG grant O grant O number O 81730017 B-AWARD 82000707 B-AWARD and O Shenkang B-ORG three-year I-ORG action I-ORG plan I-ORG project O grant O number O SHDC2020CR4014 B-AWARD Clinical B-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG Shanghai I-ORG Shenkang I-ORG Hospital I-ORG Development I-ORG Center O grant O number O SHDC12018111 B-AWARD This O study O was O financially O supported O by O Medical B-ORG and I-ORG health I-ORG plan I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2015DTA020 O Public B-ORG Technology I-ORG Application I-ORG Research I-ORG of I-ORG Zhejiang I-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Hall I-ORG 2017C33192 O and O 2016C33232 B-AWARD and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG LY13H190003 O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31371662 O and O 31461143022 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG Central I-ORG Non-profit I-ORG Scientific I-ORG Institution I-ORG Y2018PT59 O and O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-14 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 32102141 B-AWARD 32201691 B-AWARD the B-ORG central I-ORG government I-ORG guides I-ORG local I-ORG scientific I-ORG and I-ORG technological I-ORG development I-ORG projects I-ORG 20231ZDH04037 O and O the B-ORG Excellent I-ORG Youth I-ORG Science I-ORG and I-ORG Technology I-ORG Fund I-ORG Project I-ORG of I-ORG Henan I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG No. O 2022YQ23 B-AWARD This O research O was O supported O by O the O Humanity B-ORG and I-ORG Social I-ORG Science I-ORG Youth I-ORG Foundation I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG under O grant O number O 15YJC190008 B-AWARD to O JQL O seehttps://xm.sinoss.net/indexAction!to_index.action O the O Civil O Aviation O Safety O Capacity O Building O Foundation O of O Civil O Aviation O Administration O of O China O under O grant O number O OAS20150337 O seehttp://www.caac.gov.cn/dev/cws O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG China I-ORG under O grant O number O 3122017014 B-AWARD to O JQL O seehttp://www.moe.gov.cn/jyb_xxgk/moe_1777/moe_1779/201610/t20161028_286795.html O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O grant O numbers O 61201085 B-AWARD 61502127 I-AWARD and I-AWARD 61562023 I-AWARD to O HYZ O seehttp://www.nsfc.gov.cn O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81270025 O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Yunnan I-ORG 2013FB099 O and O the O 18th B-AWARD Yunnan B-ORG province I-ORG cultivation I-ORG project I-ORG of I-ORG the I-ORG skilled I-ORG personnel O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG 2020-I2M-C&T-B-049 O National B-ORG Clinical I-ORG Research I-ORG Center I-ORG for I-ORG Cardiovascular I-ORG Disease I-ORG Fuwai I-ORG Hospital I-ORG Chinese I-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG NCRC2020013 O and O China B-ORG International I-ORG Exchange I-ORG and I-ORG Promotion I-ORG Association I-ORG for I-ORG Medical I-ORG and I-ORG Healthcare I-ORG Investigator I-ORG Sponsored I-ORG Study I-ORG CN174125 O DIREGL08735-DAPT B-AWARD This O research O was O supported O from O the O Shanxi B-ORG Basic I-ORG Research I-ORG Program I-ORG No. O 20210302124322 B-AWARD Shandong B-ORG Postdoctoral I-ORG Innovation I-ORG Project I-ORG No. O SDCX-ZG-202203072 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 52205427 B-AWARD This O research O was O supported O by O the O National B-ORG Modern I-ORG Citrus I-ORG Industry I-ORG System I-ORG CARS-27 O the O Ministry B-ORG of I-ORG Education I-ORG Innovation I-ORG Team I-ORG IRT13065 O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Project I-ORG 2013BAD021302 O the B-ORG China I-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2015M582242 O and O the B-ORG Special I-ORG Project I-ORG on I-ORG the I-ORG Integration I-ORG of I-ORG Industry I-ORG Education I-ORG and I-ORG Research I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2012B091100169 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82260843 O 82060649 B-AWARD Guizhou B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG QKHZC O 2019]2953 O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guizhou I-ORG Province I-ORG QKHRCPT O 2019]1332 O Doctor B-ORG science I-ORG foundation I-ORG of I-ORG Zunyi I-ORG Medical I-ORG University I-ORG F-941 O Science B-ORG and I-ORG Technology I-ORG Fund I-ORG of I-ORG Guizhou I-ORG Provincial I-ORG Health I-ORG Commission I-ORG gzwkj2021-539 O Guizhou B-ORG Engineering I-ORG Research I-ORG Center I-ORG of I-ORG Industrial I-ORG Key-technology I-ORG for I-ORG Dendrobium I-ORG Nobile I-ORG QJJ O 2022]048 O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Zunyi I-ORG ZSKHHZ O 2022]380 O Innovative B-ORG projects I-ORG of I-ORG college I-ORG students I-ORG in I-ORG Guizhou I-ORG Province I-ORG ZYDC2020022 O This O work O was O supported O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No.2016YFB0401504 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant.51771074 O 51521002 I-AWARD and I-AWARD U1601651 O National B-ORG Key I-ORG Basic I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 973 O program I-AWARD Grant I-AWARD No.2015CB655004 O Founded B-ORG by I-ORG MOST I-ORG National I-ORG Science I-ORG Foundation I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG of I-ORG China I-ORG Grant.51725505 O Guangdong B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No.2016A030313459 O and I-AWARD 2017A030310028 O Guangdong B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG No.2016B090907001 O 2016A040403037 I-AWARD 2016B090906002 I-AWARD 2017B090907016 I-AWARD and I-AWARD 2017A050503002 O Guangzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 201804020033 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51605070 B-AWARD Department B-ORG of I-ORG Education I-ORG of I-ORG Liaoning I-ORG Province I-ORG No. O JDL2017029 B-AWARD Department B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Liaoning I-ORG Province I-ORG No. O 2019-ZD-0119 B-AWARD China O Postdoctoral O Science O Foundation O This O work O was O supported O by O Vicerrectoría B-ORG de I-ORG Investigación I-ORG Universidad I-ORG de I-ORG Costa I-ORG Rica I-ORG www.vinv.ucr.ac.cr O project O 741-B5-285 B-AWARD to O JMG O Arthritis B-ORG Research I-ORG UK I-ORG http://www.arthritisresearchuk.org O project O 19913 B-AWARD to O MV O and O the O Wellcome B-ORG Trust I-ORG https://wellcome.ac.uk O project O 098291/Z/12/Z B-AWARD to O SN O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O IGM O was O funded O by O a O Cardiff O School O of O Biosciences O PhD O studentship O ABJ O was O supported O by O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG PhD O studentship O BB/F016557/1 B-AWARD RMJ O lab O supported O by O Medical B-ORG Research I-ORG Council I-ORG grant O MR/M013960/1 B-AWARD DMB O lab O supported O by O Cancer B-ORG Research I-ORG UK I-ORG C17199/A18246 O The O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2016YFD0600801 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20181401 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31200564 O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 11604072 O Scientific B-ORG and I-ORG Technological I-ORG Research I-ORG Project I-ORG of I-ORG Hebei I-ORG Province I-ORG No. O QN2015008 O and O the O Preferentially B-ORG Supported I-ORG Project I-ORG for I-ORG People I-ORG Studying I-ORG Abroad I-ORG of I-ORG Hebei I-ORG Province I-ORG No. O C2015005010 O The O authors O also O wish O to O thank O the O Hebei O Key O Laboratory O of O Opticelectric O Information O and O Materials O and O the O National O O Local O Joint O Engineering O Laboratory O of O New O Energy O Photoelectric O Devices O for O the O measurement O assistance O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 32202390 B-AWARD 32270404 B-AWARD and O 31970375 B-AWARD the O Innovation B-ORG and I-ORG Promotion I-ORG Project I-ORG for I-ORG Forestry I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O LYKJ B-AWARD 2021]18 O the O Key B-ORG R&D I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O BE2022370 B-AWARD and O the O Open B-ORG Fund I-ORG of I-ORG Jiangsu I-ORG Key I-ORG Laboratory I-ORG for I-ORG the I-ORG Research I-ORG and I-ORG Utilization I-ORG of I-ORG Plant I-ORG Resources I-ORG No. O JSPKLB202201 B-AWARD This O work O was O supported O in O part O by O the O US O National B-ORG Institutes I-ORG of I-ORG Health I-ORG SM, O 5R01AI107949 B-AWARD JJ, O 5R01AI089819 B-AWARD AS, O R01AI104423 B-AWARD JB, O R01AI099473 B-AWARD the O Uniformed B-ORG Services I-ORG University I-ORG of I-ORG the I-ORG Health I-ORG Sciences I-ORG AS, O R0878N7 B-AWARD and O the O Naval B-ORG Medical I-ORG Research I-ORG Center I-ORG AS, O HT904-13-1-0022 B-AWARD The O funding O bodies O had O no O role O in O the O study O design O data O analysis O and O interpretation O or O preparation O of O the O manuscript O This O study O was O supported O by O the10.13039/501100001809National O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China(31871127 O and O 81901830 B-AWARD theHumanity O and I-ORG Social I-ORG Science I-ORG Youth I-ORG Foundation I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG in I-ORG China(19YJC190018 O theFeatures O Innovative I-ORG Projects I-ORG of I-ORG Guangdong I-ORG Province I-ORG Ordinary I-ORG University(2019KTSCX149 O the10.13039/501100017607Shenzhen O Basic I-ORG Research I-ORG Project(JCYJ20190808154413592 O the O postgraduate O innovation O development O fund O project O of10.13039/501100009019Shenzhen O University(315-0000470535 O the10.13039/100015549Science O and I-ORG Technology I-ORG Development I-ORG Fund O Macau O SAR O Grant O no. O 055/2015/A2 B-AWARD and O 0045/2019/AFJ B-AWARD and O theUniversity O of I-ORG Macau I-ORG Research I-ORG Committee(MYRG O projects O 2016-00240-FST B-AWARD and O 2017-00207-FST B-AWARD The O Wellcome O Centre O for O Integrative O Neuroimaging O is O supported O by O core O funding O from O the10.13039/100010269Wellcome O Trust(203139/Z/16/Z O This O research O was O funded O by O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Taiwan I-ORG MOST O 110-2314-B-037-040 O the O Kaohsiung B-ORG Medical I-ORG University I-ORG Chung-Ho I-ORG Memorial I-ORG Hospital I-ORG KMUH109-M910 O KMUH110-0M43 B-AWARD and O KMUH110-0M45 B-AWARD and O partially O supported O by O Kaohsiung B-ORG Medical I-ORG University I-ORG Research I-ORG Center I-ORG Grant O KMU-TC108A04-0 O This O study O is O financially O supported O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG University I-ORG CHD I-ORG 300102279503 O the O Fund B-ORG Project I-ORG of I-ORG Shaanxi I-ORG Key I-ORG Laboratory I-ORG of I-ORG Land I-ORG Consolidation I-ORG 2018-JC18 O 2019-JC07 B-AWARD 2019-JC08 B-AWARD and O the O Shaanxi B-ORG Provincial I-ORG Land I-ORG Engineering I-ORG Construction I-ORG Group I-ORG internal I-ORG research I-ORG project I-ORG DJNY2019-12 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Cancer I-ORG Institute I-ORG grants O R01CA178383 B-AWARD and O R01CA180006 B-AWARD to O L.D O U24CA210972 O to O D.F O L.D O and O S.P O U24CA211006 O to O L.D O and O National B-ORG Human I-ORG Genome I-ORG Research I-ORG Institute I-ORG grant O U01HG006517 B-AWARD to O L.D O F.C O is O supported O by O National B-ORG Institute I-ORG of I-ORG Diabetes I-ORG and I-ORG Digestive I-ORG and I-ORG Kidney I-ORG Diseases I-ORG grant O R01DK087960 B-AWARD This O research O was O funded O by O the O Shaanxi B-ORG Research I-ORG Station I-ORG of I-ORG Crop I-ORG Gene I-ORG Resources I-ORG and I-ORG Germplasm I-ORG Enhancement I-ORG Program I-ORG of I-ORG China I-ORG No. O Z100021811 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31971741 O and O the O Shaanxi B-ORG Innovation I-ORG Team I-ORG Project I-ORG 2018TD-004 O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC2000100 O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDA16000000 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81921006 O 92149301 B-AWARD 92168201 B-AWARD 82125011 B-AWARD 91949209 B-AWARD 92049304 B-AWARD 92049116 B-AWARD 32121001 B-AWARD 82192863 B-AWARD 82122024 B-AWARD 82071588 B-AWARD 81901432 B-AWARD 32000510 B-AWARD 81861168034 B-AWARD 32000500 B-AWARD 81901433 B-AWARD 81870228 B-AWARD 81922027 B-AWARD the O National O Key O Research O and O Development O Program O of O China O 2020YFA0804000 O 2020YFA0113400 O 2018YFA0107203 O 2020YFA0112200 O 2021YFF1201005 O 2021ZD0202401 O the O Program O of O the O Beijing O Natural O Science O Foundation O Z190019 O JQ20031 O K. B-ORG C. I-ORG Wong I-ORG Education I-ORG Foundation I-ORG GJTD-2019-06 O GJTD-2019-08 B-AWARD Young O Elite O Scientists O Sponsorship O Program O by O CAST O YESS20200012 O YESS20210002 O The O Pilot O Project O for O Public B-ORG Welfare I-ORG Development I-ORG and I-ORG Reform I-ORG of I-ORG Beijing-affiliated I-ORG Medical I-ORG Research I-ORG Institutes I-ORG 11000022T000000461062 O CAS B-ORG Project I-ORG for I-ORG Young I-ORG Scientists I-ORG in I-ORG Basic I-ORG Research I-ORG YSBR-012 O Youth B-ORG Innovation I-ORG Promotion I-ORG Association I-ORG of I-ORG CAS I-ORG E1CAZW0401 O 2022083 B-AWARD the O Informatization B-ORG Plan I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG CAS-WX2021SF-0301 O CAS-WX2022SDC-XK14 B-AWARD the O Tencent B-ORG Foundation I-ORG 2021-1045 O The O authors O thank O the O financial O support O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grants O No. O 51602056 B-AWARD 51961145108 B-AWARD U1632115,51475093 B-AWARD Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG 17JC1401700 O the O National O Key O Technologies O R&D O Program O of O China O 2015ZX02102-003 O the O Program B-ORG of I-ORG Shanghai I-ORG Academic I-ORG Research I-ORG Leader I-ORG 19XD1400600 O and O the O Changjiang O Young O Scholars O Program O of O China O This O research O was O funded O by O Soft B-ORG Science I-ORG Research I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Province I-ORG grant O number O 2022C35064 B-AWARD Medical B-ORG and I-ORG Health I-ORG Technology I-ORG Plan I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG grant O number O 2022RC126 B-AWARD and O General B-ORG Project I-ORG of I-ORG the I-ORG Department I-ORG of I-ORG Education I-ORG of I-ORG Zhejiang I-ORG Province I-ORG grant O number O Y202249243 B-AWARD The O financial O sponsor O played O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O UMR O BIPAR O is O supported O by O the O French B-ORG Government’s I-ORG Investissement I-ORG d’Avenir I-ORG program I-ORG Laboratoire I-ORG d’Excellence I-ORG “Integrative I-ORG Biology I-ORG of I-ORG Emerging I-ORG Infectious I-ORG Diseases” I-ORG grant O no. O ANR-10-LABX-62-IBEID B-AWARD V.P O obtained O funding O from O the O Research B-ORG Council I-ORG of I-ORG Lithuania I-ORG project O No O S-MIP-22-52 B-AWARD A.W.-C O was O supported O by O Programa B-ORG Nacional I-ORG de I-ORG Becas I-ORG de I-ORG Postgrado I-ORG en I-ORG el I-ORG Exterior I-ORG “Don I-ORG Carlos I-ORG Antonio I-ORG López” I-ORG Grant O No. O 205/2018 B-AWARD A.M O is O supported O by O the O ‘Collectivité B-ORG de I-ORG Corse’ O grant O ‘Formations B-AWARD superieures’ I-AWARD SGCE–RAPPORT I-AWARD N° I-AWARD 0300 I-AWARD This O work O was O supported O by O the B-ORG Doctoral I-ORG Foundation I-ORG of I-ORG University I-ORG of I-ORG Jinan I-ORG No. O XBS1748 O XBS1806 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. B-AWARD 61873324 I-AWARD 61671220 I-AWARD 61640218 I-AWARD 61201428 O the B-ORG Shandong I-ORG Distinguished I-ORG Middle-aged I-ORG and I-ORG Young I-ORG Scientist I-ORG Encourage I-ORG and I-ORG Reward I-ORG Foundation O China O Grant O No. B-AWARD ZR2016FB14 O the B-ORG Project I-ORG of I-ORG Shandong I-ORG Province I-ORG Higher I-ORG Educational I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG China I-ORG Grant O No. B-AWARD J16LN07 O the B-ORG Shandong I-ORG Province I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O No. B-AWARD ZR2018LF005 I-AWARD ZR2019MF040 O the B-ORG Shandong I-ORG Province I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG under O Grant O with O No.2018GGX101048 B-AWARD The O work O was O supported O by O theEuropean O Commission I-ORG funding I-ORG under I-ORG the I-ORG 7th I-ORG Framework I-ORG Programme(Marie O Curie O Initial O Training O Networks O grant O number O 289958 B-AWARD Bioceramics O for O bone O repair O M.M.S O and O H.A O were O financially O supported O by O theMedical O Engineering I-ORG Solutions I-ORG in I-ORG Osteoarthritis I-ORG Centre I-ORG of I-ORG Excellence I-ORG funded I-ORG by I-ORG the I-ORG Wellcome I-ORG Trust I-ORG and I-ORG the I-ORG Engineering I-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council(088844 O H.A O was O also O partially O funded O by O theValue O In I-ORG People I-ORG award I-ORG from I-ORG the I-ORG Wellcome I-ORG Trust I-ORG Institutional I-ORG Strategic I-ORG Support I-ORG Fund(097816/Z/11/B O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O raw O data O supporting O this O paper O is O available O upon O request O fromm.stevens@imperial.ac.uk O This O study O has O been O funded O by O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III I-ORG through O the O project O “CP19/00095” O Co-funded O by O European O Social O Fund O “Investing O in O your O future” O and O Consellería O de O Innovación O Universidades O Ciencia O y O Sociedad O Digital O from O Generalitat B-ORG Valenciana I-ORG CIAICO/2021/135 O given O to O C. O d O J.R O This O study O was O also O funded O by O Instituto O de O Salud O Carlos O III O ISCIII O through O the O project O PI22/00824 O and O co-funded O by O the O European O Union O FEDER O granted O to O M.S O and O C.d.J.R O FISABIO B-ORG intramural I-ORG grants O UGP-20-135 B-AWARD and O UGP-20-254 B-AWARD also O supported O this O work O S.A.-A O was O the O recipient O of O the O “Carolina O foundation O predoctoral O fellowship” O 2020 O R.M O was O funded O by O the O Spanish B-ORG Ministry I-ORG of I-ORG Economy I-ORG and I-ORG Competitiveness I-ORG PID2021-123253OB-C21 O E.R.C O was O financed O by O the O Spanish O Ministry O of O Science O Innovation O and O Universities O PTA2018-015394-I O The O FESEM O equipment O used O in O this O work O was O funded O by O the O Generalitat O Valenciana O Spain O and O co-financed O with O the O ERDF O funds O OP O ERDF O of O Comunitat O Valenciana O Spain O GVA-IDIFEDER_2018/020 B-AWARD “Una O forma O de O hacer O Europa” O Figures O were O created O in O BioRender.com O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG received O by O ZQ O grant O number O 31602139),http://www.nsfc.gov.cn B-AWARD the O Scientific O and I-ORG Technological I-ORG Innovation I-ORG Project I-ORG from I-ORG Laboratory I-ORG for I-ORG Marine I-ORG Fisheries I-ORG and I-ORG Aquaculture I-ORG Qingdao I-ORG National I-ORG Laboratory I-ORG for I-ORG Marine I-ORG Science I-ORG and I-ORG Technology I-ORG received O by O ZZ O grant O number O 2015ASKJ02),http://www.qnlm.ac/index B-AWARD and O the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG received O by O ZZ O grant O number O 2012AA10A402),http://program.most.gov.cn B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O sponsored O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31270996 O Medical B-ORG Cross I-ORG Youth I-ORG Project I-ORG of I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG YG2017QN14 O and O Funding B-ORG Project I-ORG of I-ORG Shanghai I-ORG Sixth I-ORG People’s I-ORG Hospital I-ORG ynlc201617 O This O work O was O supported O by: O University B-ORG of I-ORG Malaya I-ORG PPP I-ORG grant I-ORG PG040-2014A O to O SNMZ,http://umresearch.um.edu.my O Fundamental B-ORG Research I-ORG Grant I-ORG Scheme I-ORG FRGS I-ORG from I-ORG Ministry I-ORG of I-ORG Higher I-ORG Education O FP015-2014B O to O SNMZ,http://www.mastic.gov.my/web/guest/frgs1 O and O UM/MoHE B-ORG High I-ORG Impact I-ORG Research I-ORG Grant I-ORG UM.C O 625/1/HIR/MOHE/MED/23 O to O YALL,http://hir.um.edu.my O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O has O been O funded O by O national O funds O through O the O Foundation B-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG FCT)—projects O UIDB/04050/2020 B-AWARD UDBI/04033/2020 B-AWARD UIDB/50026/2020 B-AWARD UIDP/50026/2020 B-AWARD UIDB/50006/2020 B-AWARD UIDP/50006/2020 B-AWARD and O by O the O project O NORTE-01-0145-FEDER-000055 B-AWARD supported O by O the O Norte B-ORG Portugal I-ORG Regional I-ORG Operational I-ORG Programme I-ORG NORTE O 2020 O under O the O PORTUGAL O 2020 O Partnership O Agreement O through O the O European O Regional O Development O Fund O ERDF O S.P.C O is O recipient O of O an O FCT B-ORG grant I-ORG 2020.05779.BD O In O addition O FCT B-ORG and I-ORG FEDER-COMPETE-QREN-EU I-ORG have O been O funded O the O CQ/UM O UID/QUI/00686/2021 O The O NMR O spectrometer O Bruker O Avance O III O 400 O is O part O of O the O National O NMR O Network O and O was O purchased O within O the O framework O of O the O National O Program O for O Scientific O Re-equipment O contract O REDE/1517/RMN/2005 B-AWARD with O funds O from O POCI O 2010 I-ORG FEDER I-ORG and I-ORG FCT I-ORG This O research O was O funded O by O the O Key B-ORG Project I-ORG of I-ORG Hunan I-ORG Provincial I-ORG Education I-ORG Department I-ORG of I-ORG China I-ORG 22A0551 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG 2020JJ4073 O Hunan B-ORG Provincial I-ORG general I-ORG project I-ORG of I-ORG Education I-ORG Department I-ORG 21C0645 O Key B-ORG project I-ORG of I-ORG Huaihua I-ORG University I-ORG HHUY2021-03 O This O research O was O funded O by O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG 2015CB553602 O to O J.L O 2014CB548200 B-AWARD to O Z.F O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31701025 O to O K.C O 81571050 B-AWARD to O Z.F O 31770917 B-AWARD 31570777 B-AWARD 91649106 B-AWARD to O J.L O the O General O Financial O Grant O from O the O China O Postdoctoral O Science O Foundation O 2017M613108 O to O K.C O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Z201806073 O xjj2018081 O to O K.C O LJS O is O the O recipient O of O a O Northern B-ORG Ireland I-ORG Kidney I-ORG Research I-ORG Fund I-ORG Fellowship I-ORG NIKRF O Funding O was O also O provided O by O GEnetics O of O Nephropathy O an O International O Effort O GENIE O and O Science B-ORG Foundation I-ORG Ireland I-ORG and I-ORG the I-ORG Department I-ORG for I-ORG the I-ORG Economy I-ORG Northern I-ORG Ireland I-ORG 15/IA/3152 O This O work O has O been O partly O funded O by O the O Medical B-ORG Research I-ORG Council I-ORG Award O Reference O MC_PC_15025 B-AWARD and O the O Public B-ORG Health I-ORG Agency I-ORG R&D I-ORG Division I-ORG Award O Reference O STL/4760/13 B-AWARD None O of O the O funding O bodies O had O a O role O in O the O study O design O or O analysis O This O work O was O supported O by O the O Strategic O China-Japan O Joint O Research O Program O on O “S&T O for O Environmental O Conservation O and O Construction O of O a O Society O with O Less O Environmental O Burden” O NSFC O Grant O No. O 51021140002 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFE0127300 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51578441 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG No. O 2017JQ5074 B-AWARD the O Research O Plan O of O Science O and O Technology O Department O of O Xi’an O city O 2017071CG/RC034(SXSF002 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG University I-ORG No. O GK201603075 B-AWARD GK201601009 I-AWARD and I-AWARD GK201802108 O and O the O Youth O Innovation O Team O Project O in O the O Geography O and O Tourism O College O of O Shaanxi O Normal O University O The O APC O was O funded O by O Japan O Science O and O Technology O Agency O Science B-ORG and I-ORG Technology I-ORG Major I-ORG Projects I-ORG of I-ORG Zhejiang I-ORG Province O No. O 2018C04016 B-AWARD National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG China O No. O 2018ZX10302206 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O No. O 81201291 B-AWARD This O research O was O funded O by O Spanish O National O projects O MAT2017-87035-C2-1-P/2-P O AEI/FEDER O UE O Basque B-ORG Country I-ORG University I-ORG PPG17/07 B-AWARD and O GIU17/014 B-AWARD and O Basque B-ORG Government I-ORG PIBA2018-24 B-AWARD This O study O is O part O of O the O dissemination O activities O of O project O FunGlass O This O project O has O received O funding O from O the O European O Union’s O Horizon B-ORG 2020 I-ORG research O and O innovation O program O under O grant B-AWARD agreement I-AWARD No I-AWARD 739566 O This O study O was O also O created O in O the O frame O of O the O project O Centre O for O Functional O and O Surface O Functionalized O Glass O CEGLASS O ITMS O code O is O 313011R453 O operational O program O Research O and O innovation O co-funded O from O European O Regional O Development O Fund O The O research O was O supported O by O Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG 2021YFH0116 O 2021ZYD0101 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 52170112 O and O Dongfang B-ORG Boiler I-ORG 3521050 O This O work O is O also O supported O by O the O Research B-ORG Council I-ORG of I-ORG Norway I-ORG No. O 294533 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81703279 O Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG 2019YJ0148 O National B-ORG Major I-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG of I-ORG China O Study O on O the O assessment O technology O and O prediction O model O of O AIDS O epidemic O in O China O 2017ZX10201101 O This O work O was O supported O by O grants O from O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG of I-ORG China I-ORG Grant O No. O 2018J01169 B-AWARD the O Scientific B-ORG Research I-ORG Personnel I-ORG Training I-ORG Project I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG Fujian I-ORG Province I-ORG Grant O No. O 2017-02-03 B-AWARD the O Science B-ORG Foundation I-ORG for I-ORG Young I-ORG Scientists I-ORG of I-ORG Fujian I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG Grant O No. O 2018-2-17 B-AWARD and O the O Key B-ORG R I-ORG I-ORG D I-ORG programs I-ORG in I-ORG Shandong I-ORG 2016CYJS08A01-1 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O has O received O funding O from O the O Dutch B-ORG Cancer I-ORG Society I-ORG #UVA2013-5941 O a O European B-ORG Research I-ORG Council I-ORG Starting I-ORG Grant I-ORG #280209 O and O was O performed O within O the O framework O of O the O IMPULS2-program B-AWARD within O the O Eindhoven B-ORG University I-ORG of I-ORG Technology I-ORG in I-ORG collaboration I-ORG with I-ORG Philips O The O authors O would O like O to O acknowledge O SuperSonic O Imagine O Aix-en-Provence O France O for O providing O the O Aixplorer® O Ultrasound O platform O and O technical O support O and O NVIDIA O Corporation O for O granting O the O Titan O XP O graphics O processing O unit O This O work O is O partially O supported O by O FAPES B-ORG 209/2018—Edital O Especial O CPID O Camilo O A. O R. O Diaz O acknowledges O the O financial O support O of O FAPES O 459/2021 O CNPq B-ORG 310668/2021-2 O and O MCTI/FNDCT/FINEP B-ORG 2784/20 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81772298 O the O role O of O which O was O design O of O the O study O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG China I-ORG No.2018JJ3848 O and O No.2017JJ3338 B-AWARD the O role O of O which O were O reagents O purchase O and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Hunan I-ORG Province I-ORG China I-ORG No.2017SK2062 O the O role O of O which O was O English O editing O The O research O was O supported O by O Sirius B-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Project O ID O NRB-RND-2116 B-AWARD K.A.D O was O supported O by O St. B-ORG Petersburg I-ORG State I-ORG University I-ORG state I-ORG budgetary I-ORG funds I-ORG Project O ID O 93020614 B-AWARD The O study O partially O used O the O facilities O and O equipment O of O the O Resource B-ORG Fund I-ORG of I-ORG Applied I-ORG Genetics I-ORG MIPT I-ORG support O grant O 075-15-2021-684 B-AWARD This O work O was O supported O by O the O Fundamental O Research O Funds O of O Shandong O University-Clinical O Research I-ORG Funds I-ORG of I-ORG QiLu I-ORG Hospital I-ORG grant O number O 2014QLKY20 B-AWARD the O Research B-ORG Fund I-ORG of I-ORG Affiliated I-ORG Qilu I-ORG Hospital I-ORG of I-ORG Shandong I-ORG University I-ORG grant O number O 2015QLMS30 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81272181 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 5151101167 O U1562107 B-AWARD the B-ORG National I-ORG Key I-ORG Technology I-ORG Support I-ORG Program I-ORG of I-ORG China I-ORG 2014BAD02B03 O and O Beijing B-ORG Youth I-ORG Top-notch I-ORG Talent I-ORG Support I-ORG Project I-ORG 2015000026833ZK10 O RD O is O supported O by O R35GM124836 B-AWARD from O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG of O the O National O Institutes O of O Health O R01HL139865 B-AWARD from O the O National O Heart O Lung O Blood O Institute O of O the O National O Institutes O of O Health O and O previously O an O American B-ORG Heart I-ORG Association I-ORG Cardiovascular O Genome-Phenome O Discovery O grant O 15CVGPSD27130014 O DMJ O is O supported O by O T32HL00782 B-AWARD from O the O National B-ORG Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute I-ORG of O the O National O Institutes O of O Health O The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O National O Institutes O of O Health O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81630049 B-AWARD 81371626 B-AWARD and O 81501532 B-AWARD the O Clinical B-ORG Research I-ORG Physician I-ORG Program I-ORG of I-ORG Tongji I-ORG Medical I-ORG College I-ORG Huazhong I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG No. O 5001530008 B-AWARD and O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG No. O 2015BAI01B09 B-AWARD The O authors O acknowledge O the O financial O supports O from O National O Key O R&D O Program O of O China O 2016YFC0201103 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 51471161 B-AWARD and I-AWARD 11674320 O Natural B-ORG Science I-ORG Foundation I-ORG for I-ORG Young I-ORG Scientists I-ORG of I-ORG China I-ORG Grant O No. O 51802309 B-AWARD Anhui B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG for O Distinguished O Young O Scholar O 1408085J10 O Anhui O Provincial O Natural O Science O Foundation O Grant O No. O 1808085ME137 B-AWARD Youth O Innovation O Promotion O Association O CAS O and O Key O Research O Projects O of O the O Frontier O Science O CAS O QYZDB-SSW-JSC017 O This O study O was O supported O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31271203 O the O Humanity B-ORG and I-ORG Social I-ORG Science I-ORG Foundation I-ORG of I-ORG Ministry I-ORG of I-ORG Education O PR O China O Grant O No.14YJA190006 B-AWARD and O the O National B-ORG Social I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No.15BPRK011 B-AWARD This O work O was O supported O by O the B-ORG Key I-ORG Program I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG of I-ORG China I-ORG 81130020 O and O the B-ORG National I-ORG 973 I-ORG Program I-ORG 2015CB553500 O to O Wei O Hao O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG Central I-ORG Universities I-ORG of I-ORG Central I-ORG South I-ORG University I-ORG 2016zzts138 O to O Huixi O Dong O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31802014 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Chongqing I-ORG China I-ORG cstc2018jcyjAX0487 O cstc2018jcyjAX0211 I-AWARD cstc2016jcyjA0524 O and O Chongqing B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG XmT2018006 O This O work O was O supported O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31600866 B-AWARD Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Wuhan I-ORG Grant O No. O 2017060201010172 B-AWARD and O Guidance B-ORG Foundation I-ORG of I-ORG Renmin I-ORG Hospital I-ORG of I-ORG Wuhan I-ORG University I-ORG Grant O No. O RMYD2018M27 B-AWARD This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 8167360 O Major B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Projects I-ORG of I-ORG Shandong I-ORG Province I-ORG 2018CXG1408 O and O Science B-ORG and I-ORG Technology I-ORG Projects I-ORG for I-ORG People’s I-ORG Livelihood I-ORG of I-ORG Qingdao I-ORG 18-6-1-93-nsh O This O work O is O funded O in O part O by O the O NIH/NIMHD B-ORG Research I-ORG Centers I-ORG in I-ORG Minority I-ORG Institutions I-ORG RCMI I-ORG Coordinating I-ORG Center I-ORG award O U24MD015970 B-AWARD NIH/NIMHD B-ORG RCMI I-ORG Center I-ORG for I-ORG Health I-ORG Disparities I-ORG Research I-ORG award O U54MD012392 B-AWARD NIH/NIMHD B-ORG RCMI I-ORG Center I-ORG for I-ORG Translational I-ORG Research I-ORG in I-ORG Health I-ORG Disparities I-ORG award O U54MD007602 B-AWARD NIH/NIMHD B-ORG NCCU I-ORG RCMI I-ORG Practice I-ORG Based I-ORG Equity I-ORG Research I-ORG Network I-ORG PBERN O award O UG3MD018398 B-AWARD NIH/NCATS B-ORG Georgia I-ORG Clinical I-ORG and I-ORG Translational I-ORG Science I-ORG Alliance I-ORG GaCTSA O award O UL1TR002378 B-AWARD and O NIH/NCATS B-ORG Together I-ORG Transforming I-ORG and I-ORG Translating I-ORG Discovery I-ORG to I-ORG Improve I-ORG Health I-ORG UF-FSU O CTSI O award O UL1TR001427 B-AWARD This O research O was O funded O by O the O Science B-ORG and I-ORG Technology I-ORG Development I-ORG Project I-ORG of I-ORG Guangxi I-ORG China I-ORG 14122005-43 O the O Guangxi O Key O Laboratory B-ORG of I-ORG Marine I-ORG Natural I-ORG Products I-ORG and I-ORG Combinatorial I-ORG Biosynthesis I-ORG Chemistry I-ORG GXMNP2018002 O the B-ORG Guangxi I-ORG First-class I-ORG Discipline I-ORG Project I-ORG for I-ORG Pharmaceutical I-ORG Sciences I-ORG GXFCDP-PS-2018 O and O the B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Project I-ORG of I-ORG Qingxiu I-ORG Division I-ORG Nanning I-ORG Guangxi I-ORG Province I-ORG of I-ORG China I-ORG 2014S09 O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC0910202 O and O 2016 B-AWARD YFC I-AWARD 1306300 O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 7172076 O Beijing B-ORG cooperative I-ORG construction I-ORG project I-ORG 110651103 O Beijing B-ORG Normal I-ORG University I-ORG 11100704 O and O Peking B-ORG Union I-ORG Medical I-ORG College I-ORG Hospital I-ORG 2016-2.27 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O research O was O partially O funded O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81673389 B-AWARD the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2019YFC1711300 O the B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Fund I-ORG Macau I-ORG SAR I-ORG File O no. O 0075/2018/A2 B-AWARD 034/2017/A1 B-AWARD and O 0017/2019/AKP B-AWARD the B-ORG Guangdong I-ORG Key I-ORG Project I-ORG for I-ORG Modernization I-ORG of I-ORG Lingnan I-ORG herbs I-ORG and I-ORG the I-ORG University I-ORG of I-ORG Macau I-ORG File O no. O MYRG2018-00083-ICMS/MYRG2019-00128-ICMS/CPG2020-00021-ICMS B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41807199 O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0406105 O and O the O China B-ORG Geological I-ORG Survey I-ORG 12120113103800 O DD20190824 B-AWARD The O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81501025 O Science B-ORG Foundation I-ORG of I-ORG Xiangya I-ORG Hospital I-ORG for I-ORG Young I-ORG Scholar I-ORG No.2014Q10 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG No.2016JJ3174 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grants O 81071549 B-AWARD 81272095 B-AWARD 81772074 B-AWARD and O 81974045 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong O China O grant O 2012B050600002 B-AWARD the O Guangdong B-ORG Province I-ORG Talent I-ORG Recruitment I-ORG Foundation I-ORG and I-ORG the I-ORG Guangdong I-ORG Innovative I-ORG Research I-ORG Team I-ORG Program I-ORG No. O 201001Y0104675344 B-AWARD and O Guangzhou B-ORG Science I-ORG and I-ORG technology I-ORG project I-ORG 201804020002 O This O work O was O supported O by O the O Gatsby B-ORG Charitable I-ORG Foundation I-ORG RG62472 O the O Royal B-ORG Society I-ORG RG69135 O and O by O the O European B-ORG Research I-ORG Council I-ORG ERC-2014-STG O H2020 B-AWARD 637537 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81800514 O Innovative B-ORG Research I-ORG Team I-ORG in I-ORG University I-ORG No.IRT_17R97 O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG LY19C110001 O This O work O was O supported O by O the O Natural B-ORG Science I-ORG Key I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG Grant O No. O 2020J02042 B-AWARD and O Research B-ORG on I-ORG integration I-ORG design I-ORG and I-ORG industrialization I-ORG of I-ORG RF I-ORG components I-ORG for I-ORG 5G I-ORG wireless I-ORG communication I-ORG terminal I-ORG Grant O No. O S22042 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG of I-ORG China I-ORG Grant O No. O 2021J05179 B-AWARD This O work O was O supported O by O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFA0602303-1 B-AWARD the O Initial B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG for I-ORG the I-ORG introduction I-ORG of I-ORG talents I-ORG of I-ORG Heilongjiang I-ORG Bayi I-ORG Agricultural I-ORG University I-ORG XYB-2016-02 O National B-ORG Science I-ORG I-ORG Technology I-ORG Fundamental I-ORG Resources I-ORG Investigation I-ORG Program I-ORG of I-ORG China I-ORG 2018FY100300 O the O National B-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 41430857 B-AWARD 41671259 I-AWARD and I-AWARD 31200331 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG of I-ORG China I-ORG C2016042 O the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-04-PS17 O and O the O Program B-ORG of I-ORG Introducing I-ORG Talents I-ORG of I-ORG Discipline I-ORG to I-ORG Universities I-ORG No. O B16011 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by: O Horizon B-ORG 2020 I-ORG Framework I-ORG Programme I-ORG ERC I-ORG Grant O agreement O 647458 B-AWARD MANGO O Flanders B-ORG Institute I-ORG for I-ORG Biotechnology I-ORG VIB O grant O no. O C0401 B-AWARD IWT B-ORG SBO O grant O 60839 B-AWARD Flanders B-ORG Research I-ORG Foundation I-ORG FWO O G0I1118N B-AWARD KU B-ORG Leuven I-ORG grant O C14/17/084 B-AWARD This O work O was O supported O by O NIGMS-NIH B-ORG Award O Number O P20GM103629 B-AWARD and O the O ATS/Scleroderma B-ORG Foundation I-ORG award O 552114G1 B-AWARD C.D O was O supported O by O Wetmore B-ORG Foundation I-ORG grant O 551165G1 B-AWARD This O work O is O supported O by O the O Italian B-ORG Ministry I-ORG of I-ORG Health I-ORG GR-2009-1606736 O Regione B-ORG Lombardia I-ORG D.R.G O IX/4340 I-AWARD 26/10/2012 O and O the O Wellcome B-ORG Trust I-ORG WT097899 O This O study O was O supported O by O awards O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O No. O 81870404 B-AWARD No. O 81670518 B-AWARD and O No. O 81170392 B-AWARD Guangzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Commission I-ORG China O No. O 201604020155 B-AWARD The B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG China O No. O 2017A020215015 B-AWARD and O No. O 2014A020212118 B-AWARD This O study O was O financially O supported O by O the O Ear-marked B-ORG fund I-ORG for I-ORG Modern I-ORG Agro-Industry I-ORG Technology I-ORG Research I-ORG System I-ORG CARS-42 O the O National B-ORG Youth I-ORG Science I-ORG Fund I-ORG Project I-ORG 31301992 O the O Shandong B-ORG Modern I-ORG Agricultural I-ORG Technology I-ORG and I-ORG Industry I-ORG System I-ORG SDAIT-13-011-08 O and O the B-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Plan I-ORG projects I-ORG 2012BAD39B0402 O This O study O was O supported O by O a O grant O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no O 81401028 B-AWARD the O Youth B-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Foundation I-ORG of I-ORG Shanxi I-ORG no O 2015021201 B-AWARD and O the O Doctoral B-ORG Foundation I-ORG of I-ORG Shanxi I-ORG Medical I-ORG University I-ORG no O 03201422 B-AWARD JK O had O support O from O the O National B-ORG Institute I-ORG on I-ORG Aging I-ORG grant O P30 B-AWARD AG010124 O This O publication O was O supported O in O part O by O the O Healthy O Brain O Research O Network O HBRN O funded O by O the O Centers B-ORG for I-ORG Disease I-ORG Control I-ORG and I-ORG Prevention I-ORG CDC O Alzheimer’s O Disease O and O Healthy O Aging O Program O The O HBRN O is O a O thematic O network O of O CDC O Prevention O Research O Centers O Program O Efforts O were O supported O in O part O by O cooperative O agreements O U48 O DP I-AWARD 005053 O The O views O expressed O in O this O article O are O those O of O the O authors O and O do O not O necessarily O represent O the O official O views O of O the O CDC O JDG O had O support O from O the O National O Institute O on O Aging O grant O AG016573 B-AWARD and O the O National B-ORG Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences I-ORG UL1 O TR000153 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31672434 O 31472104 I-AWARD 31872368 O Agriculture B-ORG Research I-ORG System I-ORG of I-ORG China I-ORG CARS-35 O Weifang B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Program I-ORG 2016GX022 O and O Weifang O University O Doctoral O Foundation O Program O 2017BS10 O This O research O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32002016 O the O Special B-ORG Fund I-ORG for I-ORG Scientific I-ORG Innovation I-ORG Strategy I-ORG Construction I-ORG of I-ORG High I-ORG Level I-ORG Academy I-ORG of I-ORG Agriculture I-ORG Science I-ORG R2019PY-QY004 O the O Guangdong B-ORG Provincial I-ORG Rural I-ORG Revitalization I-ORG Strategy I-ORG Project I-ORG 2021KJ269 O the O open B-ORG competition I-ORG program I-ORG of I-ORG the I-ORG top I-ORG ten I-ORG critical I-ORG priorities I-ORG of I-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG for I-ORG the I-ORG 14th I-ORG Five-year I-ORG Plan I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2022SDZG06 O and O the O Guangdong B-ORG Provincial I-ORG science I-ORG and I-ORG technology I-ORG special I-ORG project I-ORG in I-ORG 2021 I-ORG 210907114532092 O This O work O was O financially O supported O by O the O Improved B-ORG Variety I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG of I-ORG China I-ORG 2016LZGC013 O the O Innovative O Project O of O Forestry B-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Shandong I-ORG Province I-ORG of I-ORG China I-ORG LYCX05-2018-26 O and O the O Funds B-ORG of I-ORG Shandong I-ORG “Double I-ORG Tops” I-ORG Program I-ORG SYL2017XTTD09 O This O work O was O supported O in O part O by O the O National O Nature O Science O Foundation O of O China O 61905034 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province I-ORG 2019-MS-054 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG DUT18RC(4)040 O and O the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG State I-ORG Grid I-ORG 521205190014 O This O work O was O supported O by O the O National B-ORG Key I-ORG Technologies I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2015ZX02102-003 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61874029 O and O the O Project B-ORG funded I-ORG by I-ORG China I-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M641925 O Scientific B-ORG Research I-ORG Ministry I-ORG of I-ORG Education I-ORG Culture I-ORG Sports I-ORG Science I-ORG I-ORG Technology I-ORG of I-ORG Japan I-ORG MEXT O 24241075 O to O N.T O Core O Research O for O Evolutional O Science O and O Technology O CREST O from O Japan B-ORG Science I-ORG and I-ORG Technology I-ORG Agency I-ORG JST O JPMJCR13M2 O to O I.T O and O N.T O Naito O Foundation O Grant O for O Studying O Overseas O 2013 O 2013-413 O to O H.Y O Uehara B-ORG Memorial I-ORG Foundation I-ORG Postdoctoral O Fellowship O 201430061 O to O H.Y O European O Union's O Horizon O 2020 O research O and O innovation O programme O under O the O Marie B-ORG Sklodowska-Curie I-ORG Individual I-ORG Fellowship I-ORG 657087 O to O H.Y O Funding O for O open O access O charge O JST O CREST O This O work O was O supported O by O China B-ORG TB I-ORG Control I-ORG Program I-ORG of I-ORG Global I-ORG Fund I-ORG CHN-S10-G14-T O The B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG Of I-ORG The I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG Wuhan I-ORG Municipality I-ORG WX13B22 O The B-ORG Program I-ORG of I-ORG Wuhan I-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau(201406280101265 O This O work O was O financially O supported O by O The B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFA0206500 O Key O Program O of O National O Natural O Science O Foundation O of O China O 51732002 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21905017 O Distinguished O Scientist O Program O at O BUCT O buctylkxj02 O and O The B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG ZY1722 O We O acknowledge O the O support O from O the O following O grants O 1) O KMUH110-0T04 B-AWARD and O KMUH111-1M14 B-AWARD from O the O Kaohsiung B-ORG Medical I-ORG University I-ORG Hospital O 2) O 111-2321-B-037 B-AWARD 002 I-AWARD , O 110-2321-B-037-002 B-AWARD 109-2314-B-037-019 B-AWARD 109-2314-B-037-132 B-AWARD and O 109-2314-B-037-036-MY3 B-AWARD from O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Taiwan O 3) O KMU-KI110001 B-AWARD KMU-TC109A03 B-AWARD KMU-TC111A04 B-AWARD KMU-TC108A03-6 B-AWARD and O KMU-TC109B05 B-AWARD from O Kaohsiung B-ORG Medical I-ORG University I-ORG Research I-ORG Center I-ORG Grant I-ORG This O work O was O supported O by O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG of I-ORG Jilin I-ORG Province I-ORG CXGC2018ZY009)(C6215000217)(CXGC2017ZY001 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jilin I-ORG Province I-ORG of I-ORG China I-ORG 20190201174JC O the B-ORG National I-ORG Wool I-ORG Sheep I-ORG Industry I-ORG Technical I-ORG System I-ORG CARS-39-17 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2020YFA0711700 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 12002303 B-AWARD and O ZJU-ZCCC B-ORG and O Institute O of O Collaborative O Innovation O No. O ZDJG2021002 B-AWARD The O authors O have O benefited O from O the O communication O with O Prof O G. O Wang O of O Zhejiang O University O Additionally O W. O Tu O acknowledges O the O support O of O Jiangsu B-ORG University I-ORG Faculty I-ORG Startup I-ORG Fund I-ORG 5501120014 O and O Jiangsu B-ORG Shuangchuang I-ORG Doctor I-ORG Program I-ORG 1711120022 O This O work O was O supported O by O grants O from O the O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG MOP13234 O to O JWK O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG RO1AI053721 O to O JWK O and O the O Basic O Science O Research O Program O through O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O funded O by O the O Ministry O of O Science O ICT O and O Future O Planning O NRF-2016R1D1A1B03931890 O to O WHJ O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O Pearl B-ORG River I-ORG Nova I-ORG Program I-ORG of I-ORG Guangzhou I-ORG Guangdong I-ORG Province I-ORG Grant O No. B-AWARD 2014J2200015 O Guangdong B-ORG Natural I-ORG Science I-ORG Funds I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholar I-ORG Grant O No. B-AWARD 2015A030306015 O Excellent B-ORG Young I-ORG Teachers I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG of I-ORG Guangdong I-ORG Province I-ORG Grant O No. B-AWARD YQ2015036 O and O Guangdong B-ORG Program I-ORG for I-ORG Support I-ORG of I-ORG Top-notch I-ORG Young I-ORG Professionals I-ORG Grant O No. B-AWARD 2015TQ01R279 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China—Henan I-ORG Joint I-ORG Fund I-ORG grant O no. O U1704103 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Henan I-ORG Province I-ORG 222300420453 O the B-ORG earmarked I-ORG fund I-ORG for I-ORG CARS-Wheat O 03–7 O and O the O Innovation B-ORG and I-ORG Entrepreneurship I-ORG Training I-ORG Program I-ORG of I-ORG Undergraduate I-ORG Student I-ORG in I-ORG Henan I-ORG University I-ORG 202210466062 O The O present O work O was O carried O out O with O the O support O of O the O Key B-ORG project I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Advanced I-ORG Welding I-ORG and I-ORG Joining I-ORG AWJ-19Z04 O Central B-ORG Plains I-ORG science I-ORG and I-ORG technology I-ORG innovation I-ORG talent I-ORG plan I-ORG ZYQR20180030 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG 2019YFF0217400 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 21706082 B-AWARD the O Science O and O Technology O Program O of O Guangzhou O No. O 201707020025 O No. O 201804010140 O the O Guangdong B-ORG Province I-ORG Science I-ORG Foundation I-ORG No. O 2017B090903003 B-AWARD and O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2017M622693 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 71473034 B-AWARD the O Heilongjiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O LH2019G001 B-AWARD and O the O financial O assistance O from O Postdoctoral B-ORG Scientific I-ORG Research I-ORG Developmental I-ORG Fund I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG Grant O No. O LBH-Q16003 B-AWARD All O the O funds O were O obtained O by O MW. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O collaborative O INTERREG O Interbio O project O 2011–2012 O This O work O was O also O supported O by O Fundação B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG Tecnologia I-ORG FCT-Portugal O Project O LISBOA-01-0145-FEDER-007660 B-AWARD Microbiologia O Molecular O Estrutural O e O Celular O O R&D O Unit O UID/CBQ/04612/2013 O funded O by O FEDER B-ORG funds I-ORG through O COMPETE2020 O O Programa O Operacional O Competitividadee O Internacionalizacao O POCI O and O project O PTDC/BIA-MIC/1399/2014 B-AWARD This O work O also O received O funding O from O the O European B-ORG Union’s I-ORG Horizon I-ORG 2020 I-ORG research I-ORG and I-ORG innovation I-ORG program I-ORG under O grant O agreement O No B-AWARD 635536 O Clémentine O Dressaire O and O Vânia O Pobre O were O recipient O of O FCT B-ORG Post-Doctoral I-ORG Fellowships I-ORG SFRH/BPD/65528/2009 O and O SFRH/BPD/87188/2012 B-AWARD respectively O This O work O was O supported O by O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 O Program O the B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG Grant O 2007CB512201 O and O the B-ORG Foundation I-ORG of I-ORG the I-ORG Beijing I-ORG Tongren I-ORG Hospital I-ORG Grant O 2005 O The O funders O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the O Basic B-ORG Research I-ORG Project I-ORG grant O number O 2016JB039 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Base I-ORG Program I-ORG of I-ORG Beijing I-ORG grant O number O Z141106004414084 B-AWARD Key B-ORG Projects I-ORG in I-ORG the I-ORG National I-ORG Science I-ORG I-ORG Technology I-ORG Pillar I-ORG Program I-ORG in I-ORG the I-ORG 12th-year I-ORG Plan I-ORG Period I-ORG grant O number O 2012BAK02B01 B-AWARD This O research O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51804163 O 52004130 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2021M693799 O and O the O Provincial B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG 2022JJ40373 O The O authors O are O very O grateful O for O the O financial O contribution O and O convey O their O appreciation O to O the O organization O for O supporting O this O basic O research O This O project O was O partially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31772262 O and O 31901974 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M640205 O the O Earmarked B-ORG Fund I-ORG for I-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-27 O and O The O Construction O of O Beijing O Science O and O Technology O Innovation O and O Service O Capacity O in O Top O Subjects O CEFF-PXM2019_014207_00032 O This O work O was O supported O by O the O National B-ORG Transgenic I-ORG Project I-ORG of I-ORG China I-ORG 2016ZX08006003-004 O and O 2018ZX08009-26B B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2662018JC002 O and O the O National B-ORG Swine I-ORG Industry I-ORG Technology I-ORG System I-ORG CARS-35 O This O work O was O supported O by O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 O program O 2014CB138804 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Inner I-ORG Mongolia I-ORG Autonomous I-ORG Region I-ORG of I-ORG China I-ORG 2014BS0330 O and O the O Central B-ORG Non-profit I-ORG Research I-ORG Institutes I-ORG Fundamental I-ORG Research I-ORG Funds I-ORG of I-ORG China I-ORG 1610332015004 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC1106400 O 2018YFA0108200 O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2015B020229002 O The O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2014A030312013 O 2018A030313128 O Guangdong B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG 2019B020234003 O and O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG 201803010086 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81301894 B-AWARD 81302249 O Guangzhou B-ORG Science I-ORG and I-ORG Information I-ORG Bureau I-ORG Item I-ORG No.201300000151 O of O China O Guangdong B-ORG Province I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG No.2014A020211028 O 2014A020212609 I-AWARD 2012B031800271 O of O China O and O the B-ORG scientific I-ORG research I-ORG project I-ORG for I-ORG Medical I-ORG College I-ORG of I-ORG Bureau I-ORG of I-ORG Education I-ORG of I-ORG Guangzhou I-ORG City I-ORG No.1201410508 O The B-ORG High-Level I-ORG Academic I-ORG Talent I-ORG Training I-ORG Program I-ORG of I-ORG Guangzhou I-ORG Medical I-ORG University I-ORG [2017 O 210 O B185004083 O This O work O was O partially O supported O by O Taishan B-ORG Scholars I-ORG Construction I-ORG Engineering I-ORG of I-ORG Shandong I-ORG Province I-ORG NO. O ts20130914 O Medicine B-ORG and I-ORG Health I-ORG Science I-ORG Technology I-ORG Development I-ORG Programme I-ORG of I-ORG Shandong I-ORG Province I-ORG NO. O 2015WS0226 O and O Key B-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG of I-ORG Shandong I-ORG Province I-ORG NO. O GG201709190225 O This O work O was O supported O by O the O Scientific B-ORG Grant I-ORG Agency I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG the I-ORG Slovak I-ORG Republic I-ORG and O the O Slovak B-ORG Academy I-ORG of I-ORG Sciences I-ORG the O projects O VEGA-2/0164/19 B-AWARD and O 2/0010/23 B-AWARD the O Slovak B-ORG Research I-ORG and I-ORG Development I-ORG Agency I-ORG the O project O APVV-19-0376 B-AWARD and O the O project O implementation O CEMBAM O Centre O for O Medical O Bio-Additive O Manufacturing O and O Research O ITMS2014 B-AWARD 313011V358 I-AWARD supported O by O the O Operational O Programme O Integrated O Infrastructure O funded O by O the O European B-ORG Regional I-ORG Development I-ORG Fund O This O work O was O partially O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81472620 B-AWARD Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Fund I-ORG No. O 13140902100 B-AWARD and O Shanghai B-ORG combination I-ORG study I-ORG project I-ORG for I-ORG major I-ORG diseases I-ORG No. O 2014ZYJB0101 B-AWARD This O study O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81271692 B-AWARD the B-ORG Ocean I-ORG Antithrombotic I-ORG Fibrinolytic I-ORG Enzyme I-ORG Gene I-ORG Bank I-ORG of I-ORG Taiwan I-ORG Strait I-ORG No. O 2014FJPT08 B-AWARD the B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Public I-ORG Technology I-ORG Service I-ORG Platform I-ORG of I-ORG Function I-ORG of I-ORG Drugs I-ORG and I-ORG Food I-ORG No. O 3502Z20141015 B-AWARD Education B-ORG Department I-ORG of I-ORG Fujian I-ORG Province I-ORG JA14020 O and O Subsidized B-ORG Project I-ORG for I-ORG Postgraduates’ I-ORG Innovative I-ORG Fund I-ORG in I-ORG Scientific I-ORG Research I-ORG of I-ORG Huaqiao I-ORG University I-ORG No. O 17013071028 B-AWARD This O work O was O supported O by O the O Boehringer B-ORG Ingelheim I-ORG Advancement B-AWARD in I-AWARD Equine I-AWARD Research I-AWARD Award O Harry O M. O Zweig O Memorial O Fund O for O Equine O Research O National B-ORG Institute I-ORG of I-ORG Food I-ORG and I-ORG Agriculture I-ORG under O Grant O number O 2016-67015-24765 B-AWARD the O National B-ORG Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases I-ORG of O the O National O Institutes O of O Health O under O Award O number O K08AI141767 B-AWARD and O in O part O by O the O Division O of O Intramural O Research O National O Institute O of O Craniofacial O Research O The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O National O Institutes O of O Health O This O research O is O supported O by O 1) O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 61773229 B-AWARD Funding O Body O National O Natural O Science O Foundation O of O China,http://www.nsfc.gov.cn O author O received O HTZ O 2) O Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG Grant O No. O CYZZ20150408152315667 B-AWARD Funding O Body O Shenzhen O Science O Technology O and O Innovation O Commission,http://www.szsti.gov.cn O author O received O CZZ O 3) O Basic B-ORG Scientific I-ORG Research I-ORG Program I-ORG of I-ORG Shenzhen I-ORG City I-ORG Grant O No. O JCYJ20160331184440545 B-AWARD Funding O Body O Shenzhen O Science O Technology O and O Innovation O Commission,http://www.szsti.gov.cn O author O received O HTZ O and O 4) O Cross B-ORG fund I-ORG of I-ORG Graduate I-ORG School I-ORG at I-ORG Shenzhen I-ORG Tsinghua I-ORG University I-ORG Grant O No. O JC20140001,http://www.sz.tsinghua.edu.cn B-AWARD Funding O Body O Graduate O School O at O Shenzhen O Tsinghua O University O author O received O HTZ O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O One O of O our O authors O CZZ O affiliates O to O Giiso O Information O Technology O Co O Ltd O The O funder O provided O support O in O the O form O of O salaries O for O authors O HTZ O ZYF O YJ, O CZZ O and O JYC O but O did O not O have O any O additional O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O specific O roles O of O these O authors O are O articulated O in O the O ‘author O contributions’ O section O This O work O was O supported O by O Grants-in-Aid O for O Scientific O Research O A O 16H02590 O from O the B-ORG Japan I-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG JSPS O by O a O grant O from O the O Project O of O the O NARO B-ORG Bio-oriented I-ORG Technology I-ORG Research I-ORG Advancement I-ORG Institution I-ORG the O special O scheme O project O on O vitalizing O management O entities O of O agriculture O forestry O and O fisheries O Grant O No. O 16930548 B-AWARD by O a O grant O from O the O program O for O the O promotion O of O Basic B-ORG and I-ORG Applied I-ORG Research I-ORG for I-ORG Innovations I-ORG in I-ORG the I-ORG Bio-oriented I-ORG Industry I-ORG 9151615 O This O project O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O Grant O Nos O 31902231 B-AWARD and O 31402055 B-AWARD the O College B-ORG Students I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Training I-ORG Program I-ORG of I-ORG Yangtze I-ORG University I-ORG Grant O No. O 2019110 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Research I-ORG Project I-ORG of I-ORG Department I-ORG of I-ORG Education I-ORG of I-ORG Hubei I-ORG Province I-ORG Grant O No. O Q20171305 B-AWARD the O Yangtze B-ORG Youth I-ORG Talents I-ORG Fund I-ORG Grant O No. O 2015cqr12 B-AWARD and O the O Yangtze B-ORG Youth I-ORG Fund I-ORG Grant O No. O 2015cqn39 B-AWARD The O funding O body O played O no O role O in O the O design O of O the O study O or O in O the O collection O analysis O or O interpretation O of O data O or O in O writing O the O manuscript O This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O BK20170460 B-AWARD Scientific B-ORG Research I-ORG Foundation I-ORG for I-ORG Doctor I-ORG from I-ORG Huaiyin I-ORG Institute I-ORG of I-ORG Technology I-ORG No. O Z301B16531 B-AWARD the O Fundamental B-ORG Research I-ORG Project I-ORG of I-ORG Qinghai I-ORG Science I-ORG I-ORG Technology I-ORG Department I-ORG No. O 2017-ZJ-925Q B-AWARD the O Project O of O Qinghai O Science O O Technology O Department O No. O 2016-ZJ-Y01 B-AWARD and O the O Open B-ORG Project I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Plateau I-ORG Ecology I-ORG and I-ORG Agriculture I-ORG of I-ORG Qinghai I-ORG University I-ORG No. O 2016-ZZ-06 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O through O the O Sub-Saharan B-AWARD African I-AWARD Network I-AWARD for I-AWARD TB/HIV I-AWARD Research I-AWARD Excellence I-AWARD SANTHE I-AWARD a I-AWARD DELTAS I-AWARD Africa I-AWARD Initiative I-AWARD grant I-AWARD I-AWARD DEL-15-006 I-AWARD The I-AWARD DELTAS I-AWARD Africa I-AWARD Initiative I-AWARD is I-AWARD an I-AWARD independent I-AWARD funding I-AWARD scheme I-AWARD of I-AWARD the I-AWARD African I-AWARD Academy I-AWARD of I-AWARD Sciences I-AWARD AAS)’s I-AWARD Alliance I-AWARD for I-AWARD Accelerating I-AWARD Excellence I-AWARD in I-AWARD Science I-AWARD in I-AWARD Africa I-AWARD AESA I-AWARD and I-AWARD supported I-AWARD by I-AWARD the I-AWARD New I-AWARD Partnership I-AWARD for I-AWARD Africa’s I-AWARD Development I-AWARD Planning I-AWARD and I-AWARD Coordinating I-AWARD Agency I-AWARD NEPAD I-AWARD Agency I-AWARD with I-AWARD funding I-AWARD from I-AWARD the I-AWARD Wellcome I-AWARD Trust I-AWARD grant I-AWARD I-AWARD 107752/Z/15/Z I-AWARD and O the O UK O government O The O views O expressed O in O this O publication O are O those O of O the O author(s O and O not O necessarily O those O of O AAS O NEPAD O Agency O Wellcome O Trust O or O the O UK O government O R.M.M O was O supported O by O TESA B-ORG II I-ORG which O is O part O of O the O EDCTP2 B-AWARD programme I-AWARD supported I-AWARD by I-AWARD the I-AWARD European I-AWARD Union I-AWARD grant I-AWARD number I-AWARD 1051-TESAII-RegNet2015 I-AWARD The I-AWARD views I-AWARD and I-AWARD opinions I-AWARD of I-AWARD authors I-AWARD expressed I-AWARD herein I-AWARD do I-AWARD not I-AWARD necessarily I-AWARD state I-AWARD or I-AWARD reflect I-AWARD those I-AWARD of I-AWARD EDCTP O S.M O was O supported O in O part O by O the O Fogarty B-ORG International I-ORG Center I-ORG and O National B-AWARD Institute I-AWARD of I-AWARD Mental I-AWARD Health I-AWARD of I-AWARD the I-AWARD National I-AWARD Institutes I-AWARD of I-AWARD Health I-AWARD under I-AWARD Award I-AWARD Number I-AWARD D43 I-AWARD TW010543 I-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O in O part O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG under O Grant O 2019YFB1600500 B-AWARD in O part O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O 51908054 B-AWARD in O part O by O the O Key O Research O and O Development O Program O of O Shannxi O under O Grant O 2020GY-163 O and O in O part O by O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities O CHD B-AWARD 300102220202 I-AWARD This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 61805050 B-AWARD 61705050 I-AWARD 61535004 I-AWARD 61675052 I-AWARD 61735009 I-AWARD 61765004 I-AWARD 61640409 I-AWARD 61377058 O Guangxi B-ORG Project O grant O number O 2018JJB170037 B-AWARD 2018AD19033 I-AWARD 2018AD19045 O Guangxi B-ORG Key I-ORG Laboratory I-ORG of I-ORG Automatic I-ORG Detection I-ORG Technology I-ORG and I-ORG Instrument I-ORG Foundation O grant O number O YQ19106 B-AWARD YQ18111 I-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81601053 B-AWARD the O Scientific B-ORG Research I-ORG Project I-ORG of I-ORG Liaoning I-ORG Province I-ORG Department I-ORG of I-ORG Education I-ORG No. O LK201636 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Liaoning I-ORG No. O 2012408002 B-AWARD This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81670777 B-AWARD Key B-ORG Medical I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG of I-ORG Zhejiang I-ORG Province I-ORG grant O number O WKJ-ZJ-1625 B-AWARD Wenzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG Public I-ORG Welfare I-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG grant O number:H20150001 O The O funders O played O no O role O in O the O design O of O this O study O the O collection O analysis O and O interpretation O of O data O or O preparation O of O the O manuscript O Both O A.B O and O S.B O are O supported O by O grants O from O theEuropean O Research I-ORG Council(ERC-StG-2012 O 309337_AlcoholLifecourse O PI: O Britton,http://www.ucl.ac.uk/alcohol-lifecourse O andUK O Medical I-ORG Research I-ORG Council/Alcohol I-ORG Research I-ORG UK(MR/M006638/1)—D.O.N O is O also O supported O by O the O latter O The O Whitehall O II O study O is O supported O by O grants O from O theMedical O Research O Council(K013351),British O Heart I-ORG Foundation(RG/07/008/23674),Stroke O Association I-ORG National I-ORG Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute(HL036310 O andNational O Institute I-ORG on I-ORG Aging(AG13196 O and I-AWARD AG034454 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Ministry B-ORG of I-ORG Finance I-ORG of I-ORG the I-ORG People’s I-ORG Republic I-ORG of I-ORG China I-ORG Issued O by O Finance B-AWARD and I-AWARD Social I-AWARD Security I-AWARD 2011 I-AWARD Document I-AWARD No. I-AWARD 61, I-AWARD Ministry I-AWARD of I-AWARD Finance O the O Fundamental O Research O Funds O for O the O Central O Universities O Huazhong B-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology O Wuhan O China O 2016YXMS215 O and O the B-ORG Innovation I-ORG Committee I-ORG of I-ORG Shenzhen I-ORG Science I-ORG and I-ORG Technology O “Demonstration O Application O of O Cardiovascular O and O Cerebrovascular O Disease O Prevention O and O Control O Based O on O Functional O Community” O KJYY20170413162318686 O The O funders O did O not O play O any O role O in O study O design O in O the O collection O analysis O and O interpretation O of O data O in O the O writing O of O the O report O nor O in O the O preparation O review O or O approval O of O the O manuscript O This O work O was O funded O by O NSF B-ORG International I-ORG Research I-ORG Fellowship I-ORG 0853094 B-AWARD B.S.J O by O Hatch B-ORG Project I-ORG CA-D-PLS-2017-H B-AWARD A.M.L O and O by O Deutsche B-ORG Forschungsgemeinschaft I-ORG grants O HE B-AWARD 5893/3-1 I-AWARD and O HE B-AWARD 5893/3-2 I-AWARD and O by O Bavaria B-ORG California I-ORG Technology I-ORG Center I-ORG grant O 9 B-AWARD 2001-1 I-AWARD T.H O This O work O was O supported O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG GK201703035 O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Tropical I-ORG Marine I-ORG Biology I-ORG Resources I-ORG and I-ORG Ecology I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG LMB111002 O the O Key B-ORG Research I-ORG Development I-ORG Program I-ORG of I-ORG the I-ORG Natural I-ORG Science I-ORG Basic I-ORG Research I-ORG Plan I-ORG in I-ORG Shaanxi I-ORG Province I-ORG of I-ORG China I-ORG 2018NY-106 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31600038 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Russian B-ORG Foundation I-ORG for I-ORG Basic I-ORG Research I-ORG project O no. O 20-44-596001 B-AWARD the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Higher I-ORG Education I-ORG of I-ORG the I-ORG Russian I-ORG Federation I-ORG state O task O AAAA-A20-120081990069-3 B-AWARD and O grant O agreement O 075-15-2021-1051 B-AWARD and O the O Perm B-ORG Krai I-ORG Government I-ORG project O no. O MIG B-AWARD C-26/827 O Use O of O the O Stanford O Synchrotron O Radiation O Lightsource O SLAC O National O Accelerator O Laboratory O is O supported O by O the O U.S O Department O of O Energy O Office O of O Science O Office O of O Basic O Energy O Sciences O under O Contract O No. O DE-AC01-76SF00515 O The O SSRL O Structural O Molecular O Biology O Program O is O supported O by O the O DOE O Office O of O Biological O and O Environmental O Research O and O by O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences O National O Institutes O of O Health O including O P41GM103393 O The O contents O of O this O publication O are O solely O the O responsibility O of O the O authors O and O do O not O necessarily O represent O the O official O views O of O NIGMS O or O NIH O Research O reported O in O the O publication O was O supported O by O the O National B-ORG Institute I-ORG of I-ORG Arthritis I-ORG and I-ORG Musculoskeletal I-ORG and I-ORG Skin I-ORG Diseases I-ORG NIAMS O under O award O number O R01AR063634 B-AWARD R.B.S O by O seed O money O from O the O Office O of O the O Vice O President O for O Research O TTU O R.W.S O The O National O Institute O of O General O Medical O Sciences O NIGMS O under O award O numbers O R35GM124979 B-AWARD B.J.W O and O by O Welch B-ORG Foundation I-ORG Grant O D-1876 B-AWARD M.P.L O This O work O is O supported O by O NSFC B-ORG project O 31771791 O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2016YFD0102100 O and O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-03 O of O P. O R. O China O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O US B-ORG Natural I-ORG Science I-ORG Foundation I-ORG DEB B-AWARD 0953864 I-AWARD Dr. O Heather O L O Throop O New B-ORG Mexico I-ORG State I-ORG University I-ORG I-ORG Los I-ORG Alamos I-ORG National I-ORG Lab I-ORG Collaborative B-AWARD Grant I-AWARD Dr. O Heather O L O Throop O and O Dr. O Thom O Rahn O and O Pacific B-ORG Northwest I-ORG National I-ORG Laboratory I-ORG LDRD B-AWARD Dr. O Nathan O G O McDowell O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 31971369 B-AWARD the O Fujian B-ORG Provincial I-ORG Health I-ORG Commission I-ORG for I-ORG Medical I-ORG Research I-ORG Program I-ORG grant O number O 2021ZD01006 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG grant O number O 20720220006 B-AWARD and O the O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG grant O number O 2019RU022 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 52074128 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province O China O No. O E2020209014 B-AWARD Research B-ORG project I-ORG of I-ORG basic I-ORG scientific I-ORG research I-ORG expenses I-ORG of I-ORG Hebei I-ORG Province I-ORG No. O JYG2021004 B-AWARD This O work O was O funded O by O the O General O Program O 31771397 O 81573251 B-AWARD of O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG http://www.nsfc.gov.cn O the O Major B-ORG Research I-ORG plan I-ORG of I-ORG The I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O U1435222 B-AWARD the O Program B-ORG of I-ORG International I-ORG S&T I-ORG Cooperation I-ORG No. O 2014DFB30020 B-AWARD and O the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No.2015AA020108 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Radboud B-ORG University I-ORG Medical I-ORG Centre I-ORG Junior I-ORG Researcher I-ORG award I-ORG R004002 O awarded O to O Vivian B-ORG Weerdesteyn I-ORG and O Michael O X O Cohen O The O Netherlands O Organization O for O Scientific O Research O NWO O VIDI O grant O awarded O to O Vivian O Weerdesteyn O n. O 91717369 B-AWARD project O “Roads O to O recovery” O European B-ORG Research I-ORG Council I-ORG Starting I-ORG Grant O 638589 O and O a O Hypatia O fellowship O from O the O Radboud O University O Medical O Center O awarded O to O Michael O X O Cohen O This O work O is O supported O by O grant O from O Beijing B-ORG Medical I-ORG Management I-ORG Bureau I-ORG Cultivation I-ORG Plan I-ORG PX2018079 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO. O 81871013 O and O Beijing B-ORG Tiantan I-ORG Hospital I-ORG Young I-ORG Scientist I-ORG Program I-ORG YSP O 201705 O This O work O was O financed O by O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG KYZ201543 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31871822 O 32102296 B-AWARD Guizhou B-ORG Provincial I-ORG Natural I-ORG Science I-ORG and I-ORG Foundation I-ORG ZK(2021)167 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20210671 O BK20210669 B-AWARD This O research O was O funded O by O ETHICAL B-ORG MEAT—Integrated I-ORG System I-ORG for I-ORG Sustainable I-ORG Meat I-ORG Production I-ORG project I-ORG POCI-01-0247-FEDER-072254 O co-financed O by O the O European O Regional O Development O Fund O ERDF O through O Compete O 2020–Competitiveness O and O Internationalisation O Operational O Programme O POCI O This O work O was O also O financially O supported O by O FCT B-ORG under O the O scope O of O the O strategic O funding O of O UIDB/04469/2020 B-AWARD unit O and O by O LABBELS—Associate B-ORG Laboratory I-ORG in I-ORG Biotechnology I-ORG Bioengineering I-ORG and I-ORG Microelectromechanical I-ORG Systems O LA/P/0029/2020 B-AWARD This O paper O is O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O No. O 81227901 B-AWARD 81470083 I-AWARD 81527805 I-AWARD 61231004 I-AWARD 81171390 O Key B-ORG Projects I-ORG in I-ORG the I-ORG National I-ORG Science I-ORG I-ORG Technology I-ORG Pillar I-ORG Program I-ORG during I-ORG the I-ORG Twelfth I-ORG Five-year I-ORG Plan I-ORG Period I-ORG 2012BAI23B06 B-AWARD the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG from I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG under O Grant O No. O XDB02060010 B-AWARD the B-ORG International I-ORG Innovation I-ORG Team I-ORG of I-ORG CAS I-ORG under O Grant O No. O 20140491524 B-AWARD Beijing B-ORG Municipal I-ORG Science I-ORG I-ORG Technology I-ORG Commission I-ORG No. O Z161100002616022 B-AWARD All O funding O bodies O had O no O role O in O the O study O design O collection O analysis O interpretation O of O data O and O writing O manuscript O This O research O was O funded O by O Project B-ORG of I-ORG Administration I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG of I-ORG Guangdong I-ORG Province I-ORG of I-ORG China I-ORG No. O 20181126 O and O The B-ORG Specific I-ORG Research I-ORG Fund I-ORG for I-ORG TCM I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Guangdong I-ORG Provincial I-ORG Hospital I-ORG of I-ORG Chinese I-ORG Medicine I-ORG No. O YN2018QL06 O National B-ORG Natural I-ORG Scientific I-ORG Foundation I-ORG Nos O 81703848 B-AWARD 81703877 B-AWARD Natural B-ORG Scientific I-ORG Foundation I-ORG of I-ORG Guangzhou I-ORG Province I-ORG 2017A030310123 O The B-ORG specific I-ORG Research I-ORG Fund I-ORG for I-ORG TCM I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Guangzhou I-ORG Provincial I-ORG Hospital I-ORG of I-ORG Chinese I-ORG Medicine I-ORG YN10101915 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG Grant O number O 2017YFD0501501 B-AWARD Work B-ORG Funds I-ORG for I-ORG Pig I-ORG Team I-ORG Post I-ORG Experts I-ORG of I-ORG Beijing I-ORG Innovation I-ORG Team I-ORG in I-ORG 2019 I-ORG PXM2019014207000024 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O number O 31572558 B-AWARD and O 31672597 B-AWARD This O study O was O supported O by O grants O from O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG No. O 2021A1515220037 O Shenzhen B-ORG Key I-ORG Medical I-ORG Subject I-ORG No. O SZXK023 B-AWARD Shenzhen B-ORG “San-Ming” I-ORG Project I-ORG of I-ORG Medicine I-ORG No. O SZSM201612092 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 82001319 B-AWARD Guangdong O Basic O and O Applied O Basic O Research O Foundation O No. O 2019A1515011290 B-AWARD and O 2019A1515110983 B-AWARD Bethune B-ORG Charitable I-ORG Foundation I-ORG and I-ORG CSPC I-ORG Osteoporosis I-ORG Research I-ORG Foundation I-ORG Project I-ORG No. O G-X-2020-1107-21 B-AWARD Shenzhen B-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG System I-ORG No. O SZXJ2018077 B-AWARD and O National O Natural O Science O Foundation O of O China O No. O 82272568 B-AWARD This O research O was O funded O by O European B-ORG Commission O FP7 B-AWARD EC-GA I-AWARD No. I-AWARD 279074 O Boehringher B-ORG Ingelheim I-ORG Ingelheim I-ORG am I-ORG Rhein I-ORG Germany I-ORG IIS O Program O Grant O number O 1218.166 B-AWARD Merck B-ORG Healthcare I-ORG KGaA I-ORG Darmstadt I-ORG Germany I-ORG IIS O number O EMR200084_621 B-AWARD Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III O Spain O PI11/01653 B-AWARD The O study O funders O were O not O involved O in O the O design O of O the O study O the O collection O analysis O and O interpretation O of O data O or O writing O the O report O and O did O not O impose O any O restrictions O regarding O the O publication O of O the O report O This O work O was O financially O supported O through O grants O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0500705,http://service.most.gov.cn O the O Special B-ORG Fund I-ORG for I-ORG Agro-scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG 201303044,http://www.mlr.gov.cn O and O the O Shanghai B-ORG Nature I-ORG Science I-ORG Fund I-ORG 15ZR1449700,http://www.stcsm.gov.cn O This O study O was O supported O by O the O 13th B-ORG Five-year I-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG Project O 2018YFD0400200 B-AWARD Shandong B-ORG Modern I-ORG Agricultural I-ORG Technology I-ORG System I-ORG Edible I-ORG Fungus I-ORG Innovation I-ORG Team I-ORG SDAIT-11-011-02 O and O Mushroom B-ORG Breeding I-ORG Foundation I-ORG 660-2418103 O M.M O Michela O Mazzon O and O M.M O Mark O Marsh O are O supported O by O UK O Medical B-ORG Research I-ORG Council I-ORG funding O to O the O MRC-UCL O LMCB O University O Unit O MC_UU_12018/1 O and O from O UCL O Confidence O in O Concept O and O Therapeutic O Innovation O Fund O awards O M.D O was O supported O by O a O Wellcome B-ORG Trust I-ORG New O Investigator O award O 104771/Z/14/Z O a O starting O grant O from O the O European B-ORG Research I-ORG Council I-ORG ERC-StG-2015-637304 O and O funding O through O the O Imperial O NIHR O Biomedical O Research O Centre O This O study O was O supported O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81672052 O 81971962 B-AWARD and O Zhejiang B-ORG Natural I-ORG Science I-ORG Funds I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scientists I-ORG LR17H190001 O to O FT, O National O Natural O Science O Foundation O of O China O 81702024 O to O XH, O Commonweal B-ORG Technology I-ORG Application I-ORG Project I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Province I-ORG LGF20H190001 O and O Medical B-ORG and I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2018KY865 O to O QH, O Commonweal B-ORG Technology I-ORG Application I-ORG Project I-ORG Program I-ORG of I-ORG Wenzhou I-ORG City I-ORG Y20180084 O to O SL, O National B-ORG Undergraduate I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Project I-ORG of I-ORG China I-ORG 201810343011 O to O JC. O All O funders O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O as O well O as O in O writing O the O manuscript O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31501871 O and O 31530068 B-AWARD Key B-ORG Research I-ORG Fund I-ORG on I-ORG Sciences I-ORG and I-ORG Technologies I-ORG for I-ORG Joint I-ORG Academic I-ORG Institute I-ORG and I-ORG Local I-ORG Enterprises I-ORG of I-ORG Sichuan I-ORG 2018Jz0008 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2012017yjsy153 O The O present O study O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O nos O 81701050 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG China I-ORG grant O nos O BK20160423 B-AWARD and O Lianyungang B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG grant O nos O SH1528 B-AWARD Kangda O Research O and O Development O Fund O KD2017KYJJYB001 O to O Fang O Yan O This O work O was O supported O by O funding O from O the O Simons B-ORG Foundation I-ORG Research O Award O 307705 B-AWARD to O Dr. O Stephan O Sanders O the O US O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health I-ORG P50 O MH106934 B-AWARD to O Dr. O Nenad O Sestan O and O the O Autism B-ORG Science I-ORG Foundation I-ORG 16-009 O to O Dr. O Donna O Werling O This O research O was O supported O by O the O Foundations B-ORG of I-ORG He’nan I-ORG Science I-ORG and I-ORG Technology I-ORG Committee I-ORG grant O no. O 182102110200 B-AWARD and O He’nan B-ORG Educational I-ORG Committee I-ORG grant O no. O 18A180035 B-AWARD which O provided O funding O for O the O subcellular O localization O of O JcHDZ16 O protein O and O publication O of O our O paper O The O work O was O also O supported O by O the B-ORG Fund I-ORG for I-ORG Youth I-ORG Programs I-ORG of I-ORG Zhoukou I-ORG Normal I-ORG University I-ORG grant O no. O ZKNUB3201801 B-AWARD and O the B-ORG Startup I-ORG Fund I-ORG for I-ORG Advanced I-ORG Talents I-ORG of I-ORG Zhoukou I-ORG Normal I-ORG University I-ORG grant O nos O ZKNUC2016030 B-AWARD and O ZKNUC2015121 B-AWARD which O provided O funding O for O the O salt O stress O tolerance O analysis O and O data O interpretation O This O research O was O funded O by O the B-ORG Doctoral I-ORG Scientific I-ORG Research I-ORG Start-up I-ORG Foundation I-ORG of I-ORG the I-ORG Harbin I-ORG University I-ORG of I-ORG Commerce O grant O number O 2019DS098 B-AWARD the B-ORG Young I-ORG Innovation I-ORG Talents I-ORG Project I-ORG of I-ORG the I-ORG Harbin I-ORG University I-ORG of I-ORG Commerce O grant O number O 2019CX31 B-AWARD and O the B-ORG Industrialization I-ORG Project I-ORG of I-ORG the I-ORG Harbin I-ORG University I-ORG of I-ORG Commerce O grant O number O 22CZ16 B-AWARD Y.X O L.Z O and O P.T O are O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81772369 O and O Beijing B-ORG Nova I-ORG Program I-ORG Z171100001117110 O M.P O Y.G O and O W.G O is O supported O by O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG CIFMS O 2017-I2M-3-001 B-AWARD The O Whitehall O II O study O is O supported O by O grants O from O the O Medical B-ORG Research I-ORG Council I-ORG grant O K013351 B-AWARD the O British O Heart O Foundation O grant O RG/13/2/30098 O and O the O National B-ORG Institute I-ORG on I-ORG Aging O U.S O National O Institutes O of O Health O grant O AG13196 O J. O Head O was O partially O supported O by O the O Economic B-ORG and I-ORG Social I-ORG Research I-ORG Council I-ORG grant O ES/K01336X/1 B-AWARD and O the O National O Institute O on O Aging O grant O R01AG013196 B-AWARD The O funding O bodies O did O not O play O any O role O in O the O study O design O the O collection O analysis O and O interpretation O of O the O data O the O writing O of O the O manuscript O or O the O decision O to O submit O the O paper O for O publication O This O research O was O funded O by O Universiti B-ORG Kebangsaan I-ORG Malaysia I-ORG under I-ORG Geran I-ORG Translasi I-ORG UKM I-ORG TR-UKM O grant O code O UKM-TR-006 B-AWARD In O addition O the O Ministry B-ORG of I-ORG Science I-ORG Technology I-ORG and I-ORG Innovation I-ORG MOSTI I-ORG Malaysia I-ORG provided I-ORG reliable I-ORG funds I-ORG under I-ORG the I-ORG International I-ORG Collaboration I-ORG Fund I-ORG ICF O grant O code O IF0419Q1081 B-AWARD The B-ORG European I-ORG Union’s I-ORG Horizon I-ORG 2020 I-ORG research I-ORG and I-ORG innovation I-ORG pro-gramme I-ORG provided I-ORG funds I-ORG under I-ORG the I-ORG Marie I-ORG Sklodowska-Curie I-ORG grant O agreement O no O 101008041 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U1704256 O 21671178 B-AWARD 21571159 B-AWARD the O Basic B-ORG and I-ORG Frontier I-ORG Technology I-ORG Research I-ORG Program I-ORG of I-ORG Henan I-ORG Province I-ORG 162300410033 O and O Zhongyuan B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Leading I-ORG Talents I-ORG 214200510017 O This O work O was O supported O by O the O Fundamental O Research O Funds O for O the O Central O Universities O No. O 2018YJS197 O in O part O by O the O Beijing O Intelligent O Logistics O System O Collaborative O Innovation O Center O No. O BILSCIC-2018KF-05 O in O part O by O the O General O Program O of O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O No. O 61671051 B-AWARD in O part O by O the O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 4162049 B-AWARD and O also O in O part O by O the O major O projects O of O Beijing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG No. O Z181100003218010 B-AWARD This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Beijing I-ORG Municipality I-ORG No. O 4182038 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61671054 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG China I-ORG Central I-ORG Universities I-ORG of I-ORG USTB I-ORG FRF-BR-17-004A O FRF-GF-17-B49 O and O the O Open O Project O Program O of O the O National O Laboratory O of O Pattern O Recognition O No. O 201800027 B-AWARD This O work O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81401410 O 81527804 I-AWARD 11575285 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG in I-ORG China I-ORG 2017A030313743 O the O Shenzhen B-ORG Overseas I-ORG High-Level I-ORG Talent I-ORG Peacock I-ORG Team I-ORG of I-ORG China I-ORG KQTD2016053117113327 O the O Basic B-ORG Research I-ORG Program I-ORG of I-ORG Shenzhen I-ORG in I-ORG China I-ORG JCYJ20160608153434110 O JCYJ20150831154213680 O the O Applied B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG in I-ORG China I-ORG 2015B020233014 O the O Key B-ORG Laboratory I-ORG for I-ORG Magnetic I-ORG Resonance I-ORG and I-ORG Multimodality I-ORG Imaging I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2014B030301013 O This O work O was O supported O by O funds O from O the O Spanish B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Innovation I-ORG Projects O CGL2010-22347-C02-01 B-AWARD and I-AWARD CGL2010-15693/BOS O the O Catalan B-ORG Government I-ORG Consolidated O Research I-AWARD Group I-AWARD 2009SGR608 O and O the O Czech B-ORG Scientific I-ORG Foundation I-ORG P501/12/G090 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the B-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG leaders I-ORG in I-ORG Central I-ORG Plains I-ORG Grant O No. O 194200510017 B-AWARD Provincial B-ORG Ministry I-ORG Co-construction I-ORG Project I-ORG from I-ORG Medical I-ORG Scientific I-ORG and I-ORG Technological I-ORG Research I-ORG Program I-ORG of I-ORG Henan I-ORG Province I-ORG Grant O No. O SBGJ2018020 B-AWARD and O Science B-ORG and I-ORG Technology I-ORG people-benefit I-ORG project I-ORG of I-ORG Zhengzhou I-ORG 2019KJHM0001 O Work O in O GAR’s O laboratory O is O supported O by O a O Wellcome B-ORG Trust O Investigator O Award O WT212625/Z/18/Z O MRC B-ORG Programme O grants O MR/R022259/1 O MR/J0003042/1 O MR/L020149/1 O MR/R022259/1 O and O Experimental O Challenge O Grant O DIVA O MR/L02036X/1 O MRC B-AWARD MR/N00275X/1 O Diabetes B-ORG UK I-ORG BDA/11/0004210 O BDA/15/0005275 B-AWARD BDA O 16/0005485 O grants O A.M-S O was O supported O by O MRC O New O Investigator O Research O Grant O MR/P023223/1 O GAR O also O receives O funding O from O the O European B-ORG Union’s O Horizon O 2020 O research O and O innovation O programme O via O the O Innovative B-AWARD Medicines I-AWARD Initiative I-AWARD 2 I-AWARD Joint I-AWARD Undertaking O under O grant O agreement O No O 115881 O RHAPSODY O to O GAR O This O work O is O financially O supported O in O whole O or O in O part O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81572669 O 81602386 B-AWARD 81602378 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20151561 O BK20161564 B-AWARD BK20161024 B-AWARD A B-ORG Project I-ORG Funded I-ORG by I-ORG the I-ORG Priority I-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG 2014-37 O Natural B-ORG Scientific I-ORG Research I-ORG Project I-ORG for I-ORG College I-ORG in I-ORG Jiangsu I-ORG Province I-ORG 16KJB320002 O Cooperative O Project O of O Southeast O University O and O Nanjing O Medical O University O 2242017K3DN20 O and O Project B-ORG from I-ORG Nanjing I-ORG Municipal I-ORG Committee I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 201803044 O This O study O was O supported O by O grants O from O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG Grant O No. O 2018JJ3763 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81900042 B-AWARD and O the O National B-ORG Key I-ORG Clinical I-ORG Specialty I-ORG Construction I-ORG Projects I-ORG of I-ORG China I-ORG Grant O No. O 2012-650 B-AWARD This O work O was O supported O Ministry B-ORG of I-ORG Higher I-ORG Education I-ORG Malaysia I-ORG under O Grant O Code O TRGS/1/2019/UKM/01/4/3 B-AWARD Universiti B-ORG Kebangsaan I-ORG Malaysia I-ORG Research I-ORG under O Grant O GUP-2019-020 B-AWARD and O Kursi B-ORG Sheikh I-ORG Abdullah I-ORG Fahim I-ORG under O Grant O Code O RH-2020-007 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U1401212 O 31672021 B-AWARD 32202286 B-AWARD Guizhou B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O QKH-J-ZK(2021)135 B-AWARD and O the O Young O Teacher O Foundation O of O Sun B-ORG Yat-sen I-ORG University I-ORG 19lgpy205 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51873175 B-AWARD the O Special B-ORG Foundation I-ORG Projects I-ORG for I-ORG Guiding I-ORG Technological I-ORG Innovation I-ORG and I-ORG Development I-ORG in I-ORG Gansu I-ORG Province I-ORG No. O 2019ZX-05 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Gansu I-ORG Province I-ORG in I-ORG China I-ORG 21JR7RA113 O the O Gansu B-ORG Provincial I-ORG Association I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Drive I-ORG Assist I-ORG Engineering I-ORG Project(2022-91-5 O the O Anning B-ORG District I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project(2022-JB-5 O and O Gansu B-ORG Province I-ORG Young I-ORG Talents I-ORG Team O Project O 2022LQTD15 O This O work O was O financially O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U1701243 O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG 2014A020216022 O 2016B070701017 B-AWARD 2016A030310314 B-AWARD and O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Guangzhou I-ORG 201504010014 O 201704020204 B-AWARD 201707010377 B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82130034 O the O Innovation B-ORG Capability I-ORG Support I-ORG Program I-ORG of I-ORG Shaanxi I-ORG 2021TD-57 O and O the O Li B-ORG Yunqing I-ORG Expert I-ORG Workstation I-ORG of I-ORG Yunnan I-ORG Province I-ORG 202005AF150014 O This O research O was O funded O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China O grant O number O 2017YFB0603601 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 51621003 B-AWARD and O 51504013 B-AWARD State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Silicate I-ORG Materials I-ORG for I-ORG Architectures I-ORG Wuhan O University O of O Technology O grant O number O SYSJJ2016-11 B-AWARD Part O of O this O research O was O supported O by O the O Regional B-ORG Government I-ORG of I-ORG Asturias O Grant O for O Excellence O Groups O GRUPIN-2014-093 B-AWARD Sara O Ferrnández O has O received O funding O from O the O European B-ORG Union’s I-ORG Horizon I-ORG 2020 I-ORG Research I-ORG and I-ORG Innovation I-ORG program I-ORG under O Grant O Agreement O No O 689682 B-AWARD AMBER O Adaptative O management O of O barriers O in O European O rivers O project O Alba O Ardura O holds O an O incorporation-Juan O de O la O Cierva O fellowship O Laura O Clusa O holds O a O PCTI O Grant O from O the O Asturias B-ORG Regional I-ORG Government O referenced O BP14-145 B-AWARD There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81703896 B-AWARD 81673776 O Beijing B-ORG municipal I-ORG science I-ORG and I-ORG technology I-ORG commission I-ORG grant O number O Z171100001017209 B-AWARD and O the O Capital B-ORG Health I-ORG Research I-ORG and I-ORG Development I-ORG of I-ORG Special I-ORG grant O number O 2016-2-4062 B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Institute I-ORG for I-ORG Medical I-ORG Research I-ORG Development I-ORG NIMAD O grant O no. O 987770 B-AWARD and O Royan B-ORG Institute I-ORG grant O no. O 96000189 B-AWARD to O H.B O and O Shahid B-ORG Beheshti I-ORG University I-ORG of I-ORG Medical I-ORG Sciences I-ORG grant O no. O 12466 B-AWARD and O the O Iran B-ORG National I-ORG Science I-ORG Foundation I-ORG INSF O grant O no. O 96004094 B-AWARD to O A.P O This O work O was O supported O by O a O Juntendo B-ORG University I-ORG Project O Research O Grant O adopted O number O 2021-38 B-AWARD to O H.L.T.N O a O Grant-in-Aid O for O Scientific B-ORG Research I-ORG from I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG Culture I-ORG Sports I-ORG Science I-ORG and I-ORG Technology I-ORG Japan I-ORG 21K08309 O to O F.N O a O National B-ORG Eczema I-ORG Association I-ORG Research I-ORG Grant I-ORG NEA21-ERG159 O to O G.P O and O the O Atopy O Allergy O Research O Center O Juntendo O University O Graduate O School O of O Medicine O Tokyo O Japan O This O research O was O funded O by O The B-ORG Swedish I-ORG Cancer I-ORG Foundation O grant O numbers O 200778P B-AWARD 200704P B-AWARD and O 210292JCIA B-AWARD Stockholms B-ORG Läns I-ORG Landsting I-ORG ALF O grant O number O FoUI-973795 B-AWARD The B-ORG Cancer I-ORG and I-ORG Allergy I-ORG Foundation O grant O numbers O 10662 B-AWARD 10127 B-AWARD and O 10137 B-AWARD Magnus B-ORG Bergvalls I-ORG Stiftelse O grant O number O 2020-03737 B-AWARD The B-ORG Stockholm I-ORG Cancer I-ORG Society O grant O numbers O 201242 B-AWARD and O 201092 B-AWARD and O Svenska B-ORG Läkaresällskapet O grant O number O SLS-935256 B-AWARD Authors O would O like O to O thank O to O the O Universidade B-ORG de I-ORG Vigo I-ORG for O the O financial O support O 00VI O 131H I-AWARD 641.02 O the O Xunta B-ORG de I-ORG Galicia I-ORG given O through O human O resources O grant O ED481B O 2016/079-0 O and O competitive O reference O groups O ED431C O 2016-038 O and O the O Ministerio O de O Economia O Industria O y O Competitividad O Gobierno O de O España-(TIN2016-77158-C4-2-R O RTC-2016-5257-7 O This O project O has O received O funding O from O the O European O Union’s O Horizon B-ORG 2020 I-ORG research O and O innovation O programme O under O grant O agreement O No O 769255 B-AWARD This O document O reflects O only O the O views O of O the O author(s O Neither O the O Innovation O and O Networks O Executive O Agency O INEA O nor O the O European O Commission O is O in O any O way O responsible O for O any O use O that O may O be O made O of O the O information O it O contains O The O statements O made O herein O are O solely O the O responsibility O of O the O authors O This O study O was O supported O by O grants O from O the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC1100600 O the O Shanghai B-ORG Ninth I-ORG People’s I-ORG Hospital I-ORG Lin I-ORG Program I-ORG JYLJ012 O and O the O National B-ORG High I-ORG Technology I-ORG R&D I-ORG Program I-ORG 863 O Program O 2015AA033603 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O 62174018 O the O Sichuan B-ORG Province's I-ORG Science I-ORG Fund I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG under O Con-tract O 2020JDJQ0022 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG under O Contract O 2018YFE0181500 O and O the O Key B-ORG R&D I-ORG project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2023YFG0141 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81771825 O Beijing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG D171100003017003 O and O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2017YFC1307904 O We O would O like O to O thank O the O Royal O Society O for O funding O S.J.G O through O a O URF O R.M.S O was O funded O jointly O through O a O Vice O Chancellor's O studentship O from O the O University O of O Southampton O and O a O Natural B-ORG Environment I-ORG Research I-ORG Council I-ORG NERC O studentship O award O reference O 1272561 B-AWARD We O would O also O like O to O thank O the O UK B-ORG Ocean I-ORG Acidification I-ORG programme I-ORG funded O by O NERC O DEFRA O DECC O for O additional O financial O support O through O grant O NE/H017097/1 B-AWARD for O A.J.P O S.A.A O S.J.G O and O P.R.B O and O the O European B-ORG Union I-ORG for I-ORG post-doctoral I-ORG research I-ORG funding O for O S.A.A O grant O no. O ERC-2013-CoG-617303 B-AWARD This O work O is O partially O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No.11801099 O the O Ministry B-ORG of I-ORG education I-ORG of I-ORG Humanities I-ORG and I-ORG Social I-ORG Science I-ORG project I-ORG of I-ORG China I-ORG Grant O No.18YJC910005 O and O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG of O China O Grant O No. O 2017A030310575 B-AWARD to O CD. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O grant O 9P50CA143188 B-AWARD from O the O National B-ORG Cancer I-ORG Institute I-ORG to O the O University O of O Wisconsin O Center O for O Tobacco O Research O and O Intervention O This O work O was O supported O by O a O Health O Services O Research O and O Development O Service O Merit O Review O Award O Pilot O Project O Program O Award O O I21HX001490-1 B-AWARD Dr. O Safdar O The O views O expressed O in O this O article O are O those O of O the O author(s O and O do O not O represent O the O views O of O the O U.S B-ORG Department I-ORG of I-ORG Veterans I-ORG Affairs I-ORG or O the O United O States O Government O This O project O was O supported O by O grant O number O R18HS024039 B-AWARD from O the O Agency B-ORG for I-ORG Healthcare I-ORG Research I-ORG and I-ORG Quality I-ORG Dr. O Safdar O The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O Agency O for O Healthcare O Research O This O research O was O funded O by O INIA B-ORG ref O RTA2 B-AWARD 015-00001-00-0 O the O Regional B-ORG Government I-ORG of I-ORG Extremadura I-ORG and I-ORG FEDER I-ORG ref O IB16208 B-AWARD and O GR18192 B-AWARD AGA002 O J. O Rocha-Pimienta O holds O a O research O pre-doctoral O fellowship O from O Junta B-ORG de I-ORG Extremadura I-ORG jointly O financed O by O European B-ORG Social I-ORG Fund O ref O PD18018 O J. O Espino O and O M. O Garrido O hold O post-doctoral O fellowships O from O Junta O de O Extremadura O ref O TA18002 B-AWARD and O TA18029 B-AWARD respectively O This O study O was O supported O by O the O following O grants O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O No. O 81201581 B-AWARD 81573078 I-AWARD and I-AWARD 81372566 O Support B-ORG Program I-ORG from I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG No. O 2014BAI09B06 B-AWARD National B-ORG Key I-ORG Clinical I-ORG Discipline I-ORG of I-ORG China I-ORG No. O 2014Y2-00547 B-AWARD and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG No. O 2016A030311021 B-AWARD The O funding O sources O had O no O role O in O the O study O design O data O collection O analysis O interpretation O and O manuscript O writing O Financial O support O for O this O research O was O provided O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG R01NS086312 O T32AI055433 I-AWARD R25TW009345 O Grand B-ORG Challenges I-ORG Canada I-ORG S4 O 0296-01 O and O United O Kingdom O Medical B-ORG Research I-ORG Council I-ORG MR/M007413/1 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 82173819 B-AWARD to O YX, O No. O 62076218 B-AWARD to O YW, O No. O 81773643 B-AWARD to O ZZ O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2019YFE0126200 B-AWARD to O YW O and O the O Zhejiang B-ORG Province I-ORG Public I-ORG Welfare I-ORG Technology I-ORG Application I-ORG Research I-ORG Project I-ORG No. O LGF22H010002 B-AWARD to O LW O ECU O is O thanked O for O funding O and O hosting O a O workshop O February O 2018 O where O the O paper O was O drafted O D.K.-J O thanks O the O Independent B-ORG Research I-ORG Fund I-ORG Denmark I-ORG 8021-00222B O ‘CARMA’ O for O support O O.S O was O supported O by O an O ARC B-ORG DECRA I-ORG DE170101524 B-AWARD P.M O was O supported O by O the O Generalitat B-ORG de I-ORG Catalunya I-ORG grant O no. O 2017SGR1588 B-AWARD This O work O contributes O to O the O ICTA B-ORG ‘Unit I-ORG of I-ORG Excellence’ I-ORG MinECo O MFM2015-0552 O This O work O was O supported O by O the O Foundation O for O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61571169 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG of I-ORG China I-ORG QC2014C017 O and O the O University B-ORG Nursing I-ORG Program I-ORG for I-ORG Young I-ORG Scholars I-ORG with I-ORG Creative I-ORG Talents I-ORG in I-ORG Heilongjiang I-ORG Province I-ORG UNPYSCT-2015037 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81771576 B-AWARD National O Natural O Science O Foundation O of O China O Grant O No. O 81270879 B-AWARD National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0905100 O and O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG 2016-I2M-1-002 O This O research O was O funded O by O United B-ORG States I-ORG Veterans I-ORG Administration I-ORG Department I-ORG grant O number O 2I01BX001000-10 B-AWARD Dialysis B-ORG Clinic I-ORG Inc I-ORG grant O number O DCI B-AWARD C-4149 O National B-ORG Institutes I-ORG of I-ORG Health I-ORG grant O number O NIH/NHLBIT32HL007736 B-AWARD This O research O was O funded O by O Worldwide B-ORG Cancer I-ORG Research I-ORG formally O the O Association O for O International O Cancer O Research O 12-0199 O to O L.G O Newcastle B-ORG upon I-ORG Tyne I-ORG Hospitals I-ORG NHS I-ORG Foundation I-ORG Trust I-ORG JAG/ML/0615 O to O L.G O JGW B-ORG Patterson I-ORG Foundations O BH161734 O to O L.G O and O M.A.W O This O work O was O supported O by O funding O from O the O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG http://www.cihr-irsc.gc.ca/e/193.html O Grant O Number O 246794-MPI B-AWARD received O by O TL O the O Heart B-ORG and I-ORG Stroke I-ORG Foundation I-ORG of I-ORG Canada I-ORG http://www.heartandstroke.com/site/c.ikIQLcMWJtE/b.2796497/k.BF8B/Home.htm O Grant O Number O NA6758 B-AWARD received O by O TL O and O the O Canada B-ORG Foundation I-ORG for I-ORG Innovation I-ORG http://www.innovation.ca O Grant O Number O 30954 B-AWARD received O by O TL O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O a O Conservation B-AWARD Research I-AWARD grant I-AWARD from O The B-ORG Biodiversity I-ORG Foundation I-ORG to O AB, O a O research O grant O from O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG 2017R1A2B2003579 O to O YJ, O and O by O a O grant O from O the O National B-ORG Institute I-ORG of I-ORG Biological I-ORG Resources I-ORG NIBR O funded O by O the O Ministry O of O Environment O MOE O of O the O Republic O of O Korea O NIBR201803101 O to O MSM O and O TK. O This O work O was O supported O by O the O Hong B-ORG Kong I-ORG Research I-ORG Grant I-ORG Council-General I-ORG Research I-ORG Fund I-ORG 464212 O 24115815 B-AWARD and O the O Food B-ORG and I-ORG Health I-ORG Bureau-Commissioned I-ORG Research I-ORG on I-ORG Control I-ORG of I-ORG Infectious I-ORG Diseases I-ORG CU-15-B2 O and O Health B-ORG and I-ORG Medical I-ORG Research I-ORG Fund I-ORG 15140132 O This O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 21405162 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2017MEEO59 O ZR2019MB035 B-AWARD the O Project B-ORG of I-ORG Shandong I-ORG Province I-ORG Higher I-ORG Educational I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG J18KA293 O the O cultivation O project O of O NSFC O in O Jining O Medical O University O JYP201727 O JYP201728 O Teacher O Research O Support O Foundation O in O Jining O medical O university O JY2017KJ049 O and O the O Student O Innovation O Training O Program O in O Jining O Medical O University O cx2015053 O 201610443065 O The O work O was O supported O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFB0308701 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21676003 O Beijing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG Z171100001317015 O the B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG Key I-ORG Project I-ORG of I-ORG Beijing I-ORG Municipal I-ORG Commission I-ORG of I-ORG Education I-ORG KZ201510011010 O the B-ORG Transformation I-ORG of I-ORG Scientific I-ORG and I-ORG Technological I-ORG Achievements-Promotion I-ORG Plan I-ORG Project I-ORG PXM2016_014213 O 000028 O This O study O was O supported O in O part O by O Natural B-ORG Science I-ORG Foundation I-ORG Project I-ORG of I-ORG CQ I-ORG CSTC I-ORG cstc2014jcyjjq90001 O the O Graduate B-ORG Scientific I-ORG Research I-ORG and I-ORG Innovation I-ORG Foundation I-ORG of I-ORG Chongqing I-ORG CYB17011 O Fundamental B-ORG Re-search I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 106112017CDJQJ158835 O and O the B-ORG pancreatic I-ORG cancer I-ORG action I-ORG network I-ORG translational I-ORG research I-ORG Grant I-ORG PanCAN O 16-65-IANN O This O study O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 51808310 B-AWARD National O Natural O Science O Foundation O of O China O Grant O No. O 51878366 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG Grant O No. O ZR2019PEE007 B-AWARD and O Grant O No. O ZR2016GM06 O and O High-level B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG for I-ORG the I-ORG introduction I-ORG of I-ORG talent I-ORG of I-ORG Qingdao I-ORG Agricultural I-ORG University I-ORG Grant O No. O 1118034 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31901528 B-AWARD 31871599 B-AWARD and O 32172078 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG of I-ORG Hunan I-ORG Province I-ORG No. O 2022RC1147 B-AWARD 2021JC0007 B-AWARD and O 2022JJ30285 B-AWARD and O the O Major B-ORG Project I-ORG of I-ORG Agricultural I-ORG Biological I-ORG Breeding I-ORG 2022ZD0400402 O This O study O was O supported O by O Innovative B-ORG Research I-ORG Groups I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG CHINA I-ORG No. O 81721091 B-AWARD Major B-ORG program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 91542205 B-AWARD National B-ORG S&T I-ORG Major I-ORG Project I-ORG No. O 2017ZX10203205 B-AWARD National O Natural O Science O Foundation O of O China O No. O 8150020212 B-AWARD and O Zhejiang B-ORG International I-ORG Science I-ORG and I-ORG Technology I-ORG Cooperation I-ORG Project I-ORG No. O 2016C0400 B-AWARD This O work O was O partially O supported O by O the O following O National B-ORG Institutes I-ORG of I-ORG Health I-ORG grants O CCSG O CA016672 B-AWARD RO1 O CA211615 B-AWARD and O U01 O CA201777 B-AWARD The O University O of O Texas O MD O Anderson-China O Medical O University O and O Hospital O Sister O Institution O Fund O Breast B-ORG Cancer I-ORG Research I-ORG Foundation I-ORG BCRF-17-069 O Ministry B-ORG of I-ORG Health I-ORG and I-ORG Welfare O China O Medical O University O Hospital O Cancer O Research O Center O of O Excellence O MOHW107-TDU-B-212-114024 O and O MOWH107-TDU-B-212-112015 B-AWARD T32 O Training O Grant O in O Cancer O Biology O 5T32CA186892 O to O H.-H.L O and O Center O for O Biological O Pathways O This O work O was O supported O by O Association B-ORG of I-ORG Zoos I-ORG and I-ORG Aquariums I-ORG Conservation O Endowment O Fund O Award O O 14-1239,https://www.aza.org B-AWARD and O the O Western B-ORG National I-ORG Parks I-ORG Association I-ORG Award O O 14-02,http://www.wnpa.org B-AWARD These O funding O sources O had O no O involvement O in O the O research O design O collection O analysis O and O interpretation O of O data O writing O the O report O or O in O the O decision O to O submit O the O article O for O publication O This O material O is O based O upon O work O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG Graduate O Research O Fellowship O grant O number O NSF B-AWARD DGE I-AWARD 1339067 I-AWARD https://www.nsfgrfp.org O Any O opinion O findings O and O conclusions O or O recommendations O expressed O in O this O material O are O those O of O the O authors O and O do O not O necessarily O reflect O the O views O of O the O National O Science O Foundation O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the B-ORG National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant I-ORG numbers I-ORG 71673022 B-AWARD to O FH, O 71420107023 B-AWARD and O XS] O and O the B-ORG Ministry I-ORG of I-ORG Education I-ORG Science I-ORG and I-ORG Technology I-ORG Strategy I-ORG Research I-ORG Project I-ORG grant O number O 2015KJW02 B-AWARD to O FH O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2022YFB3808800 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No: O 81973227 B-AWARD the O Research B-ORG Foundation I-ORG of I-ORG the I-ORG Education I-ORG Bureau I-ORG of I-ORG Liaoning I-ORG Province I-ORG No: O LJKMZ20221359 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O N2120007 B-AWARD This O research O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Province I-ORG grant O no. O 2108085MH260 B-AWARD the O project O funded O by O Scientific B-ORG Research I-ORG Platform I-ORG and I-ORG Base I-ORG Upgrading I-ORG Plan I-ORG of I-ORG Anhui I-ORG Medical I-ORG University I-ORG grant O no. O 2021xkjT048 B-AWARD Anhui B-ORG Province I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG grant O no. O 201904a07020032 B-AWARD Applied B-ORG Medicine I-ORG Research I-ORG Project I-ORG of I-ORG Hefei I-ORG Municipal I-ORG Health I-ORG Commission I-ORG grant O no. O 2019-172-2-15 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 81903590 B-AWARD The O funders O had O no O role O in O the O design O of O the O study O and O the O collection O analysis O and O interpretation O of O the O data O and O in O writing O the O manuscript O Funding O was O provided O by O Sundhed B-ORG og I-ORG Sygdom I-ORG Det I-ORG Frie I-ORG Forskningsråd I-ORG 11-107174 O Natur B-ORG og I-ORG Univers I-ORG Det I-ORG Frie I-ORG Forskningsråd I-ORG 4181-00515 O and O Novo B-ORG Nordisk I-ORG Fonden I-ORG DK) I-ORG 61310-0128 O and I-AWARD 15430 O to O Professor O Brage O S. O Andresen O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O grant O No. B-AWARD 61772367 O which O supported O the O collection O analysis O and O interpretation O of O data O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O No. B-AWARD 2016YFC0901704 O which O supported O the O publication O costs O and O the O Shanghai B-ORG Natural I-ORG Science I-ORG Foundation I-ORG grant O No. B-AWARD 17ZR1400200 O which O supported O the O hardware O and O software O device O We O thank O the O ISPRS O Working O group O Ⅲ/4 O and O the O Graphics O O Media O Lab O Moscow O State O University O for O providing O the O datasets O for O experiment O This O work O was O supported O by O Funding O of O Jiangsu O Innovation O Program O for O Graduate O Education O the O Fundamental O Research O Funds O for O the O Central O Universities O Grant O No. O KYLX15_0287 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61601222 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20160789 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M632303).and O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG Grant O No.2017YFC0822404 O This O research O was O supported O by O the O Consortium O for O Advanced O Research O Training O in O Africa O CARTA O CARTA O is O jointly O led O by O the O African O Population O and O Health O Research O Center O and O the O University O of O the O Witwatersrand O and O funded O by O the O Carnegie B-ORG Corporation I-ORG of I-ORG New I-ORG York I-ORG Grant O no. O B B-AWARD 8606R02 O Sida B-ORG Grant O no. O 54100113 B-AWARD and O the O DELTAS B-ORG Africa I-ORG Initiative I-ORG Grant O no. O 107768/Z/15/Z B-AWARD O Recipient O KM. O The O DELTA O Africa O Initiative O is O an O independent O funding O scheme O of O the O African O Academy O of O Sciences O AAS O Alliance O for O the O Accelerating O Excellence O in O Science O in O Africa O AESA O and O supported O by O the O New O Partnership O for O Africa’s O Development O Planning O and O Coordinating O Agency O NEPAD O Agency O with O funding O from O Wellcome O Trust O UK) O and O the O UK O government O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O D.E.R.G.-S O received O a O scholarship O from O the O Mexican B-ORG institution I-ORG CONACYT I-ORG grant O number O 384195/631929 B-AWARD 2020–2024 O This O project O received O financial O support O from O the O Mexican B-ORG institutions I-ORG CONACYT-SEP I-ORG grant O number O 287598 B-AWARD 2021 O and O CENID-SAI B-ORG INIFAP I-ORG grant O number O 9495336224 B-AWARD 2021 O This O work O was O supported O by O the O Hainan B-ORG Provincial I-ORG Joint I-ORG Project I-ORG of I-ORG Sanya I-ORG Yazhou I-ORG Bay I-ORG Science I-ORG and I-ORG Technology I-ORG City I-ORG NO.820LH027 O the O Open B-ORG Project I-ORG Program I-ORG of I-ORG Wuhan I-ORG National I-ORG Laboratory I-ORG for I-ORG Optoelectronics I-ORG NO.2021WNLOKF008 O the O Hainan B-ORG University I-ORG Scientific I-ORG Research I-ORG Foundation I-ORG KYQD(ZR)20078 O and O KYQD(ZR)19107 B-AWARD This O work O was O supported O by O the O European B-ORG Research I-ORG Council I-ORG CoG-724489 O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG U01 O EB021223 O and O the O Human B-ORG Frontier I-ORG Science I-ORG Program I-ORG RGY0065/2017 O These O entities O had O no O part O in O the O design O of O this O software O nor O the O collection O analysis O or O interpretation O of O data O or O composition O of O the O manuscript O Open O access O funding O provided O by O Projekt O DEAL O This O work O was O supported O by O PhD O Fellow O 2020.06582.BD B-AWARD from O FCT B-ORG Scientific B-ORG Project I-ORG 2022.01066.PTDC B-AWARD and O Strategic B-ORG Plan I-ORG UIDP/04950/2020 B-AWARD COMPETE O and O FEDER O funds O FCT O Portugal O ICNAS-Pharma O This O study O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG Nos O 2017JJ3478 B-AWARD 2018JJ6058 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81702068 B-AWARD the O Graduate B-ORG Free I-ORG Exploration I-ORG Foundation I-ORG of I-ORG Central I-ORG South I-ORG University I-ORG 2019zzts796 O and O the O Undergraduate B-ORG Free I-ORG Exploration I-ORG Foundation I-ORG of I-ORG Central I-ORG South I-ORG University I-ORG XCX20190585 O The O authors O declare O that O the O funding O body O was O not O involved O in O study O design O data O collection O analysis O interpretation O and O writing O of O the O study O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31972052 B-AWARD 31671839 B-AWARD 31820103010 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG JUSRP22006 O JUSRP51501 B-AWARD the O National O First-class O Discipline O Program O of O Food O Science O and O Technology O JUFSTR20180102 O the O Program O of O Collaborative O Innovation O Centre O of O Food O Safety O and O Quality O Control O in O Jiangsu O Province O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20180613 O This O work O was O supported O by O China B-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Achievements I-ORG Transformation I-ORG Project(2014 O by O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Province I-ORG 20142BAB214008 O 20151BAB204003 O and O by O the O Development B-ORG Foundation I-ORG of I-ORG Key I-ORG Lab I-ORG of I-ORG Protection I-ORG and I-ORG Utilization I-ORG of I-ORG Subtropic I-ORG Plant I-ORG Resources(YRD201405 O This O research O was O funded O by O grants O from O the O National B-ORG Institute I-ORG of I-ORG Environmental I-ORG Health I-ORG Sciences I-ORG NIEHS O P30 B-AWARD ES007033 I-AWARD sponsored-University O of O Washington O UW) O Center O for O Exposures O Diseases O Genomics O and O Environment O EDGE O pilot O grant O to O EH O Ahn O UW B-ORG Office I-ORG of I-ORG Research I-ORG Royalty I-ORG Research I-ORG Fund I-ORG to O EH O Ahn O and O the O National B-ORG Cancer I-ORG Institute I-ORG NCI O P30 B-AWARD CA015704-39 I-AWARD Fred O Hutchinson O Cancer O Research O Center-UW O Cancer O Consortium O Support O Grant O to O EH O Ahn O NCI O of O the O National O Institutes O of O Health O NIH O under O award O number O R21 B-AWARD CA220111 I-AWARD to O EH O Ahn O and O NCI O of O NIH O under O award O numbers O P01 B-AWARD AG001751 I-AWARD and O R33 B-AWARD CA181771 I-AWARD to O LA O Loeb O The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O NIH O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 52103107 O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG 2021A1515110405 O 2019A1515110645 B-AWARD 2019A1515111049 B-AWARD the O Open B-ORG Fund I-ORG for I-ORG Key I-ORG Lab I-ORG of I-ORG Guangdong I-ORG High I-ORG Property I-ORG and I-ORG Functional I-ORG Macromolecular I-ORG Materials O China O 20220612 O 20220615 B-AWARD the O Guangdong B-ORG Key I-ORG Laboratory I-ORG for I-ORG Hydrogen I-ORG Energy I-ORG Technologies I-ORG 2018B030322005 O the B-ORG College I-ORG Students’ I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Training I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG S202211847048 O the O Laboratory B-ORG Open I-ORG Innovation I-ORG Fund I-ORG and I-ORG Student I-ORG Academic I-ORG Fund I-ORG of I-ORG Foshan I-ORG University I-ORG xsjj202206zrb04 O xsjj202206zrb05 B-AWARD This O work O was O financed O by O national O funds O from O FCT-Fundação O para I-ORG a I-ORG Ciência I-ORG e I-ORG a I-ORG Tecnologia O I.P O within O the O scope O of O projects O UI/BD/151292/2021 B-AWARD Ph.D O research O scholarship O LA/P/0037/2020 B-AWARD UIDP/50025/2020 B-AWARD and O UIDB/50025/2020 B-AWARD of O the O Associate O Laboratory O Institute O of O Nanostructures O Nanomodelling O and O Nanofabrication-i3N O but O also O the O 2021.03825.CEECIND B-AWARD Acknowledgments O are O also O given O to O the O EC O project O SYNERGY O H2020-WIDESPREAD-2020-5 O CSA O proposal O nº O 952169 B-AWARD EMERGE-2020-INFRAIA-2020-1 O proposal O nº O 101008701 B-AWARD and O to O the O European B-ORG Community’s O H2020 O program O under O grant O agreement O No. O 787410 B-AWARD ERC-2018-AdG O DIGISMART O This O study O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81472427 B-AWARD 81672574 B-AWARD and O 81702547 B-AWARD Shanghai B-ORG Health I-ORG System I-ORG Outstanding I-ORG Talents I-ORG Program I-ORG grant O number O 2018YQ23 B-AWARD and O the O Shanghai B-ORG Sailing I-ORG Program I-ORG grant O number O 17YF1415300 B-AWARD The O funding O bodies O played O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript” O This O study O was O supported O by O Liaoning B-ORG Education I-ORG and I-ORG Science I-ORG Program I-ORG grant O number O JG15DB458 B-AWARD Liaoning B-ORG Humanities I-ORG and I-ORG Social I-ORG Science I-ORG Program I-ORG grant O number O LR201605 B-AWARD and O Liaoning B-ORG Higher I-ORG Education I-ORG Society I-ORG grant O number O WYZD150058 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O has O received O funding O from O the O Beijing B-ORG Municipal I-ORG Science I-ORG I-ORG Technology I-ORG Commission I-ORG No. O Z181100001718099 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81501469 O and O National B-ORG health I-ORG and I-ORG family I-ORG planning I-ORG commission I-ORG public I-ORG service I-ORG 201402019 O The O funding O body O had O no O involvement O in O the O design O of O the O study O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the O China B-ORG Agricultural I-ORG Research I-ORG Service I-ORG Fund I-ORG CARS-33 O Guangdong B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2016A030310458 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO. O 31601705 O These O funding O sources O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31760382 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Henan I-ORG Province I-ORG Grant O No. O 152102110136 B-AWARD and O 172102110076 B-AWARD the O Inner B-ORG Mongolia I-ORG Science I-ORG I-ORG Technology I-ORG Plan-Innovation I-ORG Team I-ORG Grant O No. O 201503004),The B-AWARD funder O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Financial O support O from O the O Czech B-ORG Science I-ORG Foundation I-ORG project O no. O 19-03207S B-AWARD from O the O Ministry B-ORG of I-ORG Health I-ORG CR-DRO I-ORG Institute O for O Clinical O and O Experimental O Medicine O IKEM O IN00023001 B-AWARD from O the O OP O RDE O project O “Improving O schematics I-ORG of I-ORG Doctoral I-ORG student I-ORG grant I-ORG competition I-ORG and I-ORG their I-ORG pilot I-ORG implementation” O Reg O No. O CZ.02.2.69/0.0/0.0/19_073/0016713 B-AWARD Doctoral O Student I-ORG Grant I-ORG Competition O grant O number O DSGC-2021-0113 B-AWARD and O from O the O Internal B-ORG Grant I-ORG Agency I-ORG of I-ORG Palacký I-ORG University I-ORG projects O no. O IGA_PrF_2022_003 B-AWARD IGA_PrF_2023_003 B-AWARD is O gratefully O acknowledged O Participants O recruitment O and O data O collection O in O this O study O were O supported O by O Beijing B-ORG Municipal I-ORG Science I-ORG I-ORG Technology I-ORG Commission I-ORG 953850700 O the B-ORG National I-ORG Science I-ORG I-ORG Technology I-ORG Pillar I-ORG Program I-ORG during I-ORG the I-ORG Eleventh I-ORG Five-Year I-ORG Plan I-ORG Period I-ORG 2006BAI01A01 O and I-AWARD 2006BAI01A02 O and O the B-ORG National I-ORG Science I-ORG I-ORG Technology I-ORG Pillar I-ORG Program I-ORG during I-ORG the I-ORG Twelfth I-ORG Five-Year I-ORG Plan I-ORG Period I-ORG 2011BAI09B01 O The O study O design O data O analysis O interpretation O and O other O pertinent O aspects O were O funded O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81170266 O 81070226 I-AWARD and I-AWARD 81570409 O Beijing O China O This O research O was O funded O by O the B-ORG study I-ORG on I-ORG key I-ORG technologies I-ORG for I-ORG healthy I-ORG production I-ORG of I-ORG efficient I-ORG resources I-ORG utilization I-ORG in I-ORG protected I-ORG vegetables I-ORG 2016BZ09 O by O research B-ORG on I-ORG key I-ORG technologies I-ORG and I-ORG supporting I-ORG equipment I-ORG of I-ORG protected I-ORG vegetable I-ORG production I-ORG CX161002 O and O by O the B-ORG achievement I-ORG transformation I-ORG of I-ORG multilayer I-ORG stereo I-ORG water I-ORG culture I-ORG AA16380048 O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O No. O 61803077 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG under O Grant O No. O F2016501080 B-AWARD and O No. O F2015501097 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG under O Grant O No. O N172304024 B-AWARD The O APC O was O funded O by O Fundamental O Research O Funds O for O the O Central O Universities O under O Grant O No. O N172304024 O The O work O presented O in O this O paper O was O funded O by O the O work O presented O in O this O paper O was O funded O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.51679181 O the B-ORG Major I-ORG Project I-ORG of I-ORG Technological I-ORG Innovation I-ORG in I-ORG Hubei I-ORG Province I-ORG No.2016AAA007 O and O the B-ORG Science-technology I-ORG Funds I-ORG for I-ORG Overseas I-ORG Chinese I-ORG Talents I-ORG of I-ORG Hubei I-ORG Province I-ORG No.2016-12 O This O work O was O supported O by O a O research O grant O from O the O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III-FEDER O PI18/01947 O J.L O was O supported O by O the O Nicolás B-ORG Monardes I-ORG Program I-ORG from I-ORG the I-ORG Andalusian I-ORG Health I-ORG Service I-ORG C-0033-2015 O J.D.P.-P O is O funded O by O a O FPU2019 O fellowship O FPU190/02269 O from O the O Ministerio B-ORG de I-ORG Universidades I-ORG Spain O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG to O X.L O 31571625 O the O Guangzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Key I-ORG Program I-ORG to O X.L O 201707020015 O the O Key O Realm O R&D O Program O of O Guangdong O Province O 2018B020202012 O the O Opening O Foundation O from O the O State O Key O Laboratory O for O Conservation O and O Utilization O of O Subtropical O Agro-bioresources O SKLCUSA-b202006 O the O Guangdong B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG to O J.W O 2018A030313644 O and O the O Featured O Innovation O Project O of O Guangdong O Education O Department O to O J.W O 2019KTSCX019 O This O work O is O supported O in O part O by O the O National B-ORG Institute I-ORG of I-ORG Biomedical I-ORG Imaging I-ORG and I-ORG Bioengineering I-ORG NIBIB O under O grant O no. O R01EB000194 B-AWARD P41 B-AWARD EB032840 I-AWARD and O by O the O UC O Davis O Paul O Calabresi O Career O Development O Award O for O Clinical O Oncology O as O funded O by O the O National B-ORG Cancer I-ORG Institute/National I-ORG Institutes I-ORG of I-ORG Health I-ORG through O grant O no. O 5K12-CA138464 B-AWARD This O work O was O supported O in O part O by O grants O from O Fondo B-ORG de I-ORG Investigación I-ORG Sanitaria I-ORG www.isciii.es O PI15/00713 O Plan O Nacional O de O I+D+I O and O Fondo B-ORG Europeo I-ORG de I-ORG Desarrollo I-ORG Regional-FEDER I-ORG www.red.es/redes/inicio O RD12/0017/006 O and O Fundación B-ORG Progreso I-ORG y I-ORG salud I-ORG Junta I-ORG de I-ORG Andalucía I-ORG www.fps2.junta-andalucia.es/fundacionprogresoysalud/es/home O PI-0411-2014 O Federico O García O has O received O a O research O extension O grant O from O the O Programa O de O Intensificación O de O la O Actividad O de O Investigación O del O Servicio O Andaluz O de O Salud O This O research O is O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 41761013 B-AWARD the O Special B-ORG Project I-ORG for I-ORG Construction I-ORG of I-ORG Innovation I-ORG Environment I-ORG in I-ORG Xinjiang I-ORG Uygur I-ORG Autonomous I-ORG Region—Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Base I-ORG Construction I-ORG Project I-ORG Grant O No. O PT2107 B-AWARD and O the O Subproject B-ORG of I-ORG the I-ORG Third I-ORG Xinjiang I-ORG Comprehensive I-ORG Scientific I-ORG Investigation I-ORG Project I-ORG No. O 2021xjkk140305 B-AWARD This O project O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41573061 O and I-AWARD 41703105 O Provincial B-ORG Natural I-ORG Science I-ORG Research I-ORG Foundation I-ORG of I-ORG Colleges I-ORG and I-ORG Universities I-ORG in I-ORG Jiangsu I-ORG Province I-ORG 17KJB170009 O Research B-ORG Projects I-ORG of I-ORG Water I-ORG Environment I-ORG Comprehensive I-ORG Management I-ORG in I-ORG Taihu I-ORG Lake I-ORG of I-ORG Jiangsu I-ORG Province I-ORG TH2014402 O Provincial B-ORG Natural I-ORG Science I-ORG Research I-ORG Foundation I-ORG of I-ORG Colleges I-ORG and I-ORG Universities I-ORG in I-ORG Anhui I-ORG Province I-ORG KJ2017A445 O and O Opening B-ORG Foundation I-ORG of I-ORG Collaborative I-ORG Innovation I-ORG Center I-ORG of I-ORG Regional I-ORG development I-ORG in I-ORG Suzhou I-ORG City I-ORG Anhui I-ORG Province I-ORG 2016szxt02 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31890771 O 31922057 B-AWARD The B-ORG Project I-ORG for I-ORG Cultivating I-ORG Excellent I-ORG Doctoral I-ORG Dissertation I-ORG of I-ORG Forestry I-ORG Engineering I-ORG LYGCYB202002 O and O the O Young B-ORG Elite I-ORG Scientists I-ORG Sponsorship I-ORG Program I-ORG of I-ORG the I-ORG National I-ORG Forestry I-ORG and I-ORG Grassland I-ORG Administration I-ORG of I-ORG China I-ORG 2019132614 O This O study O was O supported O by O Guizhou B-ORG province I-ORG international I-ORG technology I-ORG cooperation I-ORG plan(20137028 O Guizhou B-ORG provincial I-ORG fine-quality I-ORG green I-ORG branch I-ORG specialized I-ORG talents I-ORG cultivation I-ORG fund(201343 O The B-ORG national I-ORG natural I-ORG science I-ORG foundation I-ORG of I-ORG China I-ORG 81200539 O Guizhou B-ORG province I-ORG department I-ORG of I-ORG a I-ORG joint I-ORG fund(20147002 O This O research O was O funded O by O the O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG Brasil I-ORG CAPES O Finance O Code O 001 B-AWARD the O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq O process O no: O 404746/2018-7 B-AWARD 312136/2018-8 B-AWARD 309435/2020-0 B-AWARD and O 310269/2021 B-AWARD the O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Distrito I-ORG Federal I-ORG FAPDF O process O no. O 00193.0000168/2019-87 B-AWARD Edital O 11/2022 O process O no O 00193-00001219/2022-93 B-AWARD Decanato B-ORG de I-ORG Pesquisa I-ORG e I-ORG Inovação I-ORG DPI O Edital O 04/2019 O and O Decanato O de O Pós-Graduação O Edital O 03/2021 O Edital O 04/2021 O Edital O 006/2021—Fellowship O 23106.104941/2021-71 B-AWARD The O authors O would O like O to O thank O the O Region B-ORG Bourgogne-Franche-Comté I-ORG 2020Y-22065 O and O 2022Y-13186 B-AWARD and O the O National B-ORG Council I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Development I-ORG – I-ORG CNPq I-ORG 200391/2022-4 O for O funding O this O research O This O work O was O supported O by O grants O to O BAR O from O the O Natural B-ORG Sciences I-ORG and I-ORG Engineering I-ORG Research I-ORG Council I-ORG of I-ORG Canada I-ORG Discovery O Grant O RGPIN-2014-04947;http://www.nserc-crsng.gc.ca/index_eng.asp B-AWARD Google B-ORG Faculty O Research I-AWARD Award I-AWARD 2016;https://research.google.com/research-outreach.html#/research-outreach/faculty-engagement/faculty-research-awards O and O the O Canadian B-ORG Institute I-ORG for I-ORG Advanced I-ORG Research I-ORG Learning O in I-AWARD Machines I-AWARD and I-AWARD Brains I-AWARD Fellowship;https://www.cifar.ca O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31930098 B-AWARD 32172560 B-AWARD Hebei B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Fund I-ORG for I-ORG Distinguished I-ORG Young I-ORG Grant O No. O C2020204063 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG and I-ORG basic I-ORG research I-ORG project I-ORG in I-ORG Hebei I-ORG Province I-ORG Grant O No. O 18966925D B-AWARD The B-ORG Innovative I-ORG Research I-ORG Group I-ORG Project I-ORG of I-ORG Hebei I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O No. O C2020204111 B-AWARD The B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Hebei I-ORG Grant O No. O 21326311D-2 B-AWARD and O Innovation B-ORG Capability I-ORG Enhancement I-ORG Program I-ORG Project I-ORG of I-ORG Hebei I-ORG Province I-ORG Grant O No. O 20567610H B-AWARD The O study O was O supported O by O Research B-AWARD Project I-AWARD No. I-AWARD MSM0021620819 I-AWARD “Replacement O of, O and O support O to O some O vital O organs” O awarded O by O the O Ministry B-ORG of I-ORG Education I-ORG of I-ORG the I-ORG Czech I-ORG Republic O by O Charles B-ORG University I-ORG Research I-ORG Fund I-ORG project O number O P36 B-AWARD and O by O Internal O Grant O of O Department O of O Internal O Medicine O number O 6008 B-AWARD O Institutional B-ORG Grant I-ORG Teaching I-ORG Hospital I-ORG Motol I-ORG Fund O of O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 31060127 B-AWARD 81260442 B-AWARD 81560508 B-AWARD and O 31560254 B-AWARD and O Key B-ORG Program I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U1432248 O and O Program B-ORG for I-ORG Leading I-ORG Talent I-ORG of I-ORG SEAC I-ORG [2016]57 O and O National B-ORG Undergraduate I-ORG Training I-ORG Programs I-ORG for I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG 201610742002 O Our O work O is O supported O by O grants O from O the O European B-ORG Commission I-ORG Cooperative O Research O Projects O ‘sysVASC’ O 603288 O ‘HOMAGE’ O 305507 O and O ‘PRIORITY’ O 101813 O and O the O British B-ORG Heart I-ORG Foundation I-ORG Centre O of O Research O Excellence O Award O RE/13/5/30177 B-AWARD SAN O is O supported O by O the O Medical B-ORG Research I-ORG Council I-ORG MR/L019108/1 O and O British O Heart O Foundation O PG/17/17/32877 O The O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81301604 O Program B-ORG of I-ORG Medical I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Shandong I-ORG Province I-ORG 2016WS0696 O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Yantai I-ORG 2016WS033 O This O work O is O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Xinjiang I-ORG Uygur I-ORG Autonomous I-ORG Region I-ORG of I-ORG China I-ORG 2020D01C062 O 2020Q72 B-AWARD 2021D01D09 B-AWARD and O 2021D01C097 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 22105163 O U2003307 B-AWARD the O Open B-ORG Project I-ORG of I-ORG Key I-ORG Laboratory I-ORG in I-ORG Xinjiang I-ORG Uygur I-ORG Autonomous I-ORG Region I-ORG of I-ORG China I-ORG 2022D04032 O Scientific B-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Higher I-ORG Education I-ORG Institution I-ORG of I-ORG Xinjiang I-ORG XJEDU2021Y005 O Open B-ORG Project I-ORG of I-ORG PCOSS I-ORG Xiamen O University O 2021X20 O and O the O University B-ORG Student I-ORG Innovation I-ORG Program I-ORG S202110755132 O This O work O is O supported O in O part O by O funding O from O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG U01GM092691 O UH2AR067677 I-AWARD U19AI111224 I-AWARD SR O the O Doris B-ORG Duke I-ORG Charitable I-ORG Foundation I-ORG Grant O 2013097 B-AWARD the O Ruth O L. O Kirschstein O National O Research O Service O Award O F31AR070582 O from O the O National B-ORG Institute I-ORG of I-ORG Arthritis I-ORG and I-ORG Musculoskeletal I-ORG and I-ORG Skin I-ORG Diseases I-ORG KS) O and O the O Rheumatology B-ORG Research I-ORG Foundation I-ORG Tobé B-AWARD and I-AWARD Stephen I-AWARD E. I-AWARD Malawista I-AWARD MD I-AWARD Endowment I-AWARD in I-AWARD Academic I-AWARD Rheumatology I-AWARD D.A.R O This O work O is O also O supported O by O unrestricted O funding O from O Pfizer O Inc O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31600281 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20171269 O and O Top-notch B-ORG Academic I-ORG Programs I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PPZY2015A018 O The O study O was O supported O by O the O National B-ORG Council I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Development I-ORG CNPQ O 401235/2020-3 B-AWARD 302935/2021-5 B-AWARD Fundação B-ORG Amazônia I-ORG de I-ORG Amparo I-ORG a I-ORG Estudos I-ORG e I-ORG Pesquisa I-ORG do I-ORG Pará I-ORG FAPESPA O 005/2020 B-AWARD and O 006/2020 B-AWARD and O Secretaria B-ORG de I-ORG Ciência I-ORG Tecnologia I-ORG e I-ORG Educação I-ORG Superior I-ORG Profissional I-ORG e I-ORG Tecnológica I-ORG SECTET O 09/2021 B-AWARD This O research O was O funded O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grants O 2021ZY10 B-AWARD the O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grants O 5224042 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grants O 32270476 B-AWARD and O the O Guiding B-ORG project I-ORG of I-ORG science I-ORG and I-ORG technology I-ORG plan I-ORG of I-ORG Fujian I-ORG Grants O 2021N0023 B-AWARD This O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31400904;http://www.nsfc.gov.cn/) B-AWARD Xinmiao B-ORG project I-ORG of I-ORG Guangzhou I-ORG University I-ORG 2014-27;http://english.gzhu.edu.cn O Guangzhou B-ORG University's I-ORG 2017 I-ORG training I-ORG program I-ORG for I-ORG young I-ORG top-notch I-ORG personnels I-ORG BJ201715 O and O Foundation B-ORG of I-ORG Guangzhou I-ORG Shishu I-ORG Gaoxiao I-ORG Project I-ORG Grant O No. O 1201431330;http://english.gzhu.edu.cn B-AWARD MCW O received O those O funds O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG under O grant O no. O 2017YFD050080 B-AWARD China B-ORG Agricultural I-ORG Research I-ORG System I-ORG under O grant O no. O CARS-42-17 B-AWARD Sichuan B-ORG Veterinary I-ORG Medicine I-ORG and I-ORG Drug I-ORG Innovation I-ORG Group I-ORG of I-ORG China I-ORG Agricultural I-ORG Research I-ORG System I-ORG under O grant O no. O CARS-SVDIP B-AWARD International B-ORG S&T I-ORG Cooperation I-ORG Program I-ORG of I-ORG Sichuan I-ORG Province I-ORG under O grant O no. O 2017HH0026 B-AWARD and O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG of I-ORG Guizhou I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Science I-ORG under O grant O no. O 2017)03 B-AWARD The O funders O had O no O role O in O study O design O and O collection O analysis O and O interpretation O of O data O or O preparation O of O the O manuscript O This O research O was O supported O by O the O US B-ORG Department I-ORG of I-ORG Defense’s I-ORG Threat I-ORG Reduction I-ORG Agency I-ORG DTRA O Biological O Threat O Reduction O Program O BTRP O and O Cooperative O Biological O Engagement O Program O CBEP O contract O HDTRA1-08-D-0007-0004 B-AWARD for O scientific O research O in O Ukraine O with O sub-awards O for O support O for O the O State O Scientific O Program O of O NSC O IECVM O 38.01.02.01 O to O D.M O A.G O and O B.S O and O under O a O DTRA O BV/Metabiota O sub-award O UP-4 O from O the O University O of O Alaska O Anchorage O to O E.B O Additional O support O was O provided O in O part O for O bioinformatics O by O an O Institutional O Development O Award O IDeA O from O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG of O the O National O Institutes O of O Health O at O the O University O of O Alaska O under O grant O number O 2P20GM103395 B-AWARD through O a O graduate O research O fellowship O to O A.C.K O and O a O bioinformatics O core O award O “Pathogenomics O Toolkit” O to O E.B O Support O for O the O ideation O of O data O management O procedures O was O provided O by O the O NIAID B-ORG Centers I-ORG of O Excellence O for O Influenza O Research O and O Surveillance/Response O CEIRS O HHSN272201400008C B-AWARD and O CEIRR O 75N93021C00014 B-AWARD subawards O to O E.B O The O research O was O supported O by O the O Czech B-ORG Science I-ORG Foundation I-ORG 15-13415Y O Ministry B-ORG of I-ORG Culture I-ORG of I-ORG the I-ORG Czech I-ORG Republic I-ORG DKRVO O 2019–2023/6.VII.b I-AWARD National I-AWARD Museum I-AWARD 00023272 O and O the O Masaryk B-ORG University I-ORG MUNI/A/1098/2019 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Financial O support O was O provided O by O the O China B-ORG Scholarship I-ORG Council I-ORG #201506600040)-China O Knut B-ORG and I-ORG Alice I-ORG Wallenberg I-ORG Foundation I-ORG #2015.0047 O the O Academy B-ORG of I-ORG Finland I-ORG Finnish I-ORG Centre I-ORG of I-ORG Excellence I-ORG Program I-ORG #307331 O Kone O Foundation O Helsinki O University O Funds O and O the O Finnish O Society O of O Forest O Sciences O SMS O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81672409 B-AWARD Jiangsu B-ORG Provincial I-ORG Medical I-ORG Youth I-ORG Talent I-ORG QNRC2016700 O the B-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG and I-ORG Demonstration I-ORG Project I-ORG of I-ORG Nantong I-ORG City I-ORG MS12019026 O MS12018061 O and O Postgraduate B-ORG Research I-ORG I-ORG Practice I-ORG Innovation I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG SJCX18_0831 O O.D.E O and O C.M.H O acknowledge O funding O from O The B-ORG Ohio I-ORG State I-ORG University I-ORG Technology I-ORG Commercialisation I-ORG Office I-ORG Accelerator I-ORG Award I-ORG GRT00051721 O G.S.S O acknowledges O grant O support O from O NIGMS B-ORG R01GM099040 O D.S O acknowledges O funding O from O the O Centre B-ORG for I-ORG Research I-ORG of I-ORG Pathogenicity I-ORG and I-ORG Virulence I-ORG of I-ORG Parasites I-ORG no. O CZ.02.1.01/0.0/0.0/16_019/0000759 B-AWARD funded O by O the O European O Regional O Development O Fund O ERDF O and O Ministry O of O Education O Youth O and O Sport O Czech O Republic O MEYS O Research O at O the O CDIPD O was O funded O in O part O by O the O NIH-NIAID B-ORG award O R21AI126296 O to O C.R.C O ALD O and O CMS O were O supported O by O the O British O Heart O Foundation O BHF O BHF O Programme O Grant O RG/17/2/32808 B-AWARD awarded O to O CMS O MYS O and O CMG O were O supported O by O National B-ORG Institutes I-ORG of I-ORG Health I-ORG grants O R35HL139602 B-AWARD R01HL081785 I-AWARD R01HL62329 I-AWARD and I-AWARD R01HL114611 O MS O was O supported O by O NIH B-ORG grants O R35HL139602 B-AWARD R01HL114611 I-AWARD and I-AWARD R01DK094434 I-AWARD XX: O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O numbers O 31770044 B-AWARD and O 31270132),http://www.nsfc.gov.cn B-AWARD State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Freshwater I-ORG Ecology I-ORG and I-ORG Biotechnology I-ORG at O IHB O CAS O 2019FBZ09),http://febl.ihb.cas.cn O Knowledge B-ORG Innovation I-ORG Project I-ORG of I-ORG Hubei I-ORG Province I-ORG 2017CFA021),http://kjt.hubei.gov.cnThe O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O MD O Anderson O SPOREs O in O Ovarian O Cancer O NCI B-AWARD P50 I-AWARD CA I-AWARD 83639 I-AWARD and O NCI B-AWARD P50 I-AWARD CA217685 O National B-ORG Cancer I-ORG Institute I-ORG R01 B-AWARD CA135354 O the O Cancer B-ORG Prevention I-ORG and I-ORG Research I-ORG Institute I-ORG of I-ORG Texas I-ORG RP110595-P1 B-AWARD the O Shared O Resources O of O the O MD O Anderson O CCSG O grant O NCI B-AWARD P30 I-AWARD CA16672 O The O National O Foundation O for O Cancer O Research O and O generous O donations O from O Stuart O and O Gaye-Lynn O Zarrow O and O the O Roberson O endowment O M.N.S O and O G.Y.H O received O support O from O the O Ann B-AWARD and I-AWARD Sol I-AWARD Schreiber I-AWARD Mentored I-AWARD Investigator I-AWARD Award I-AWARD from O the O Ovarian B-ORG Cancer I-ORG Research I-ORG Fund I-ORG Alliance O G.Y.H O was O supported O by O the O TRIUMPH O Postdoctoral O Fellowship O program O CPRIT O grant O no. O RP170067 B-AWARD Research O reported O in O this O publication O was O supported O by O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG of I-ORG the I-ORG National I-ORG Institutes I-ORG of I-ORG Health I-ORG NIH O 5P20GM109096 O Additional O support O was O provided O by O University B-ORG of I-ORG Arkansas I-ORG for I-ORG Medical I-ORG Sciences I-ORG Translational I-ORG Research I-ORG Institute I-ORG funding O awarded O through O the O National O Center O for O Advancing O Translational O Sciences O of O the O NIH O 1U54TR001629-01A1 O KL2 B-AWARD TR003108 O UL1 B-AWARD TR003107 O The O project O described O was O also O supported O by O the O National B-ORG Institute I-ORG of I-ORG Nursing I-ORG Research I-ORG of I-ORG the I-ORG NIH I-ORG 1R21NR020677-01 O The O content O of O this O paper O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O funders O Funders O had O no O role O in O the O design O analysis O or O writing O of O this O article O This O research O was O supported O by O the O Basic O Science O Research O Program O through O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O which O is O funded O by O the O Ministry O of O Science O and O ICT O 2014M3A9D3034164 O 2015R1C1A1A01053509 O 2016R1C1B1011180 O the O Ministry B-ORG of I-ORG Education I-ORG 2015R1D1A3A03020378 O These O funds O were O used O in O the O design O of O the O study O and O data O collection O Additional O funding O was O provided O by O the O Ministry B-ORG of I-ORG Trade I-ORG Industry I-ORG and I-ORG Energy I-ORG R0005886 O and O was O used O for O the O statistical O analyses O data O interpretation O and O writing O of O the O manuscript O and O revision O This O study O was O supported O by O the O “Strategic B-ORG Priority I-ORG Research I-ORG Program” I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Science I-ORG grant O number O XDB06010103 B-AWARD the O Knowledge B-ORG Innovation I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG grant O number O SIDSSE-201304 B-AWARD and O the O Hundred B-ORG Talent I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG grant O number O SIDSSE-BR-201302 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O Science B-ORG and I-ORG Technology I-ORG Benefiting I-ORG People I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 81703355 O Project O of O Chengdu O No. O 2015-HM01-00335-SF O Sichuan B-ORG Education I-ORG Department I-ORG No. O 18TD0023 O Science B-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Sichuan I-ORG Province I-ORG No. O 2016HH0075 O Chun-Hui O Project O from O Ministry O of O Education O of O China O No.172507 O Open O research O Subject O of O Key O Laboratory O of O Food O Biotechnology O of O Sichuan O province O of O China O No. O szj2016-021 O and O the O Center O of O Comprehensive O Health O Management O No. O szj2017-043 O The O APC O was O funded O by O Young O Scholars O Reserve O Talents O program O of O Xihua O University O No. O 0220170305 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81701405 O the O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG 2018-I2M-1-004 O CAMS B-ORG Fund I-ORG for I-ORG Excellent I-ORG Young I-ORG Medical I-ORG Talents I-ORG 2018RC310024 O Key B-ORG Medical I-ORG Science I-ORG Research I-ORG Projects I-ORG of I-ORG Hebei I-ORG Province I-ORG 20200154 O This O study O was O supported O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2018YFC1105200 B-AWARD the B-ORG Key I-ORG research I-ORG and I-ORG development I-ORG plan I-ORG in I-ORG Zhejiang I-ORG province I-ORG No. O 2018C03060 B-AWARD National B-ORG Nature I-ORG Science I-ORG Fund I-ORG of I-ORG China I-ORG 81802680 O National O Nature O Science O Fund O of O China O 81972504 O No O benefits O in O any O form O have O been O or O will O be O received O from O a O commercial O party O related O directly O or O indirectly O to O the O subject O of O this O manuscript O The O study O was O supported O by O the O University B-ORG of I-ORG Macau I-ORG MYRG2015-00230-FHS O MYRG2016-00005-FHS B-AWARD the O National B-ORG Key I-ORG Research I-ORG I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFC1307200 B-AWARD the O Beijing B-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospitals I-ORG Clinical I-ORG Medicine I-ORG Development I-ORG of I-ORG Special I-ORG Funding I-ORG Support I-ORG No. O ZYLX201607 B-AWARD and O the O Beijing B-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospitals’ I-ORG Ascent I-ORG Plan I-ORG No. O DFL20151801 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG #2021CFA016 O the O Second B-ORG National I-ORG Survey I-ORG of I-ORG Terrestrial I-ORG Wildlife I-ORG Resources I-ORG in I-ORG Ta-pa I-ORG Montanans I-ORG Na07-1 O of O Hubei O Province O China O and O the O Natioal B-ORG Science I-ORG and I-ORG Technology I-ORG Infrastructure I-ORG Program I-ORG #2013BAD03B01-02 O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2018YFD0201105 B-AWARD The O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31660033 O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Hainan I-ORG Province I-ORG No. O ZDYF2018240 B-AWARD The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Strategic O Priority O Research O Program O of O the O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG grant O No. O XDC07020403 B-AWARD the O Major B-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG Special I-ORG Program I-ORG of I-ORG China I-ORG grant O No. O 2017ZX05008-008-041 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O No. O 41574106 B-AWARD This O work O was O supported O by O the O Zhongnan B-ORG Hospital I-ORG of I-ORG Wuhan I-ORG University I-ORG Science I-ORG Technology I-ORG and I-ORG Innovation I-ORG Seed I-ORG Fund I-ORG under I-ORG Grant I-ORG znpy2017022 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81172257 O and O the O Open-ended O Fund O of O the O Wuhan B-ORG National I-ORG Laboratory I-ORG for I-ORG Optoelectronics I-ORG 2018WNLOKF023 O This O study O was O supported O by O grants O from O the O Basic O Science O Research O Program O through O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG funded O by O the O Ministry O of O Education O 2020R1I1A306867013 O and O 2021R1A4A302712212 B-AWARD the O Korea B-ORG Research I-ORG Institute I-ORG of I-ORG Bioscience I-ORG and I-ORG Biotechnology I-ORG Research I-ORG Initiative I-ORG Program I-ORG KGM4562222 O and O the O Research B-ORG Program I-ORG for I-ORG Agricultural I-ORG Science I-ORG I-ORG Technology I-ORG Development I-ORG and I-ORG the I-ORG National I-ORG Institute I-ORG of I-ORG Agricultural I-ORG Sciences O PJ013833 O Rural O Development O Administration O Republic O of O Korea O This O research O was O funded O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2021YFC2009100 B-AWARD Zhejiang B-ORG Province I-ORG Key I-ORG R I-ORG I-ORG D I-ORG programs I-ORG No. O 2020C03039 B-AWARD No. O 2021C03003 B-AWARD No. O 2021C03062 B-AWARD No. O 2021C03108 B-AWARD No. O 2022C03029 B-AWARD Zhejiang B-ORG Basic I-ORG Public I-ORG Welfare I-ORG Technology I-ORG Application I-ORG Research I-ORG No. O LGF20H040006 B-AWARD and O The O 4 O O X O clinical O research O project O of O Women’s O Hospital O School O of O Medicine B-ORG Zhejiang I-ORG University I-ORG No. O ZDFY2021-4×102 B-AWARD This O work O was O supported O by O the O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31460348 O 30960195 B-AWARD Project B-ORG of I-ORG Application I-ORG Development I-ORG and I-ORG Research I-ORG of I-ORG Agricultural I-ORG Biotechnology I-ORG of I-ORG Gansu I-ORG Province I-ORG GNSW-2015-18 O Research B-ORG Program I-ORG Sponsored I-ORG by I-ORG Gansu I-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Aridland I-ORG Crop I-ORG Science I-ORG Gansu I-ORG Agricultural I-ORG University I-ORG GSCS-2010-04 O and O Fuxi B-ORG Youth I-ORG Talent I-ORG Program I-ORG of I-ORG Gansu I-ORG Agricultural I-ORG University I-ORG FXRC20130102 O This O work O was O financially O supported O by O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG of I-ORG Jilin I-ORG Province I-ORG CXGC2017ZD011 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31570507 O Modern B-ORG Agroindustrial I-ORG Technology I-ORG Research I-ORG Systems I-ORG in I-ORG China I-ORG CARS-36 O and O Changchun B-ORG Industry-University-Research I-ORG I-ORG Innovation I-ORG demonstration I-ORG site I-ORG construction I-ORG project I-ORG 16CX20 O The O funding O bodies O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O this O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81873317 O 81704096 B-AWARD 81603635 B-AWARD a O grant O from O the B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai-TCM I-ORG key I-ORG project I-ORG 16401970100 O a O grant O from O the B-ORG Shanghai I-ORG TCM I-ORG Medical I-ORG Center I-ORG of I-ORG Chronic I-ORG Disease I-ORG 2017ZZ01010 O a O grant O from O the B-ORG National I-ORG Thirteenth I-ORG Five-Year I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Special I-ORG Project I-ORG for I-ORG New I-ORG Drug I-ORG Innovation I-ORG and I-ORG Development I-ORG 2017ZX09304001 O Funded O by O CW, O RC, O NJW O NH, O SJO O Food B-ORG Standards I-ORG Agency O UK O FSA O Project O FS101072);https://www.food.gov.uk B-AWARD SJO O KF, O NJS O TJH O FJB O NH, O CW: O ENIGMA O was O funded O by O the O Medical B-ORG Research I-ORG Council O Natural O Environment O Research O Council O Economic O and O Social O Research O Council O Biotechnology O and O Biosciences O Research O Council O and O Food O Standards O Agency O through O the O Environmental O and O Social O Ecology O of O Human O Infectious O Diseases O Initiative O ESEI O Project O no. O G1100799/1);https://mrc.ukri.org B-AWARD SJO O FJB O CHF O CW: O INTEGRATE O was O funded O by O the O Wellcome B-ORG Trust I-ORG and O Department O of O Health O through O the O Health O Innovation O Challenge O Fund O HICF O Grant O Reference O HICF-T5-354);https://wellcome.ac.uk B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O a O Sir O Charles O Hercus O Fellowship O from O the O Health B-ORG Research I-ORG Council I-ORG of I-ORG New I-ORG Zealand I-ORG SW, O 09/099,http://www.hrc.govt.nz B-AWARD Deutsche B-ORG Forschungsgemeinschaft I-ORG SH, O GRK1870,http://www.dfg.de B-AWARD and O the O Bundesministerium B-ORG für I-ORG Bildung I-ORG und I-ORG Forschung I-ORG BB, O InVAC,https://www.bmbf.de B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O interpretation O or O the O decision O to O submit O the O work O for O publication O CF O was O supported O by O the O Department B-ORG for I-ORG International I-ORG Development O Wellcome O Epidemic O Preparedness O O Coronavirus O research O programme O ref O 221303/Z/20/Z B-AWARD SG, O RR, O NA O and O FC O were O supported O by O UK O Research O and O Innovation O as O part O of O the O Global B-ORG Challenges I-ORG Research I-ORG Fund O grant O number O ES/P010873/1 B-AWARD SI O is O supported O by O a O Wellcome B-ORG Trust I-ORG Clinical O Research O Training O Fellowship O re. O 215654/Z/19/Z B-AWARD This O work O was O supported O by O Research O Grants O from O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG 15411950300 O Cancer B-ORG Research I-ORG Youth I-ORG Science I-ORG Foundation I-ORG of I-ORG Chinese I-ORG Anti-Cancer I-ORG Association I-ORG CAYC18A49 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81972589 O 81672745 B-AWARD 81702673 B-AWARD Shanghai B-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG Foundation I-ORG of I-ORG China I-ORG 201540257 O Shanghai B-ORG Area I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG Foundation I-ORG of I-ORG China I-ORG 20151005 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O financially O supported O by O the O Basic O Science O Research O Program O through O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O funded O by O the O Ministry B-ORG of I-ORG Education I-ORG Science I-ORG and I-ORG Technology I-ORG number O 2013R1A1A2A10011202 B-AWARD 2014R1A2A1A11050768 B-AWARD and O by O the O Technology B-ORG Innovation I-ORG Program I-ORG 10060155 O funded O By O the O Ministry O of O Trade O industry O O Energy O MI, O Korea O and O the O KRIBB O Initiative O Research O Program O KRIBB O Korea O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81570274 B-AWARD 81870328 B-AWARD and O 81800267 B-AWARD University-College B-ORG Joint I-ORG Cultivation I-ORG Fund I-ORG of I-ORG Zhengzhou I-ORG University I-ORG 2016-BSTDJJ-19 B-AWARD Henan B-ORG Medical I-ORG Science I-ORG and I-ORG Technology I-ORG Joint I-ORG Building I-ORG Program I-ORG No. O 2018020002 B-AWARD The O fund O provider O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O No O additional O external O funding O was O received O for O this O study O This O work O was O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province I-ORG No. O 2014029201 B-AWARD Program B-ORG of I-ORG Education I-ORG Department I-ORG of I-ORG Liaoning I-ORG Province I-ORG L2014307 O and O Clinical B-ORG Capability I-ORG Construction I-ORG Project I-ORG for I-ORG Liaoning I-ORG Provincial I-ORG Hospitals I-ORG LNCCC-A01-2014 O The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O 81788101 B-AWARD the O Chinese B-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG Grant O 2017-12M-1-009 B-AWARD Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2020YFC0846300 O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG 2018ZX10711001 O and O Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG 202002073000001 O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81272874 B-AWARD 81472438 B-AWARD the B-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Liaoning I-ORG Province I-ORG grant O number O 2013225079 B-AWARD Shenyang B-ORG City I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG grant O number O F14-158-9-47 B-AWARD and O the B-ORG Outstanding I-ORG Scientific I-ORG Fund I-ORG of I-ORG Shengjing I-ORG Hospital I-ORG grant O number O 201601 B-AWARD Funding O for O open O access O was O provided O by O the O National O Natural O Science O Foundation O of O China O grant O number O 81272874 O 81472438 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81402084 B-AWARD 81472378 B-AWARD the O Shanghai B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG No. O 2013SY027 B-AWARD and O the O Incubating B-ORG Program I-ORG for I-ORG Clinical I-ORG Research I-ORG and I-ORG Innovation I-ORG of I-ORG Renji I-ORG Hospital I-ORG No. O PYXJS16-008 B-AWARD This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 31370194 B-AWARD and O 31570163 B-AWARD Science B-ORG and I-ORG Technology I-ORG Projects I-ORG of I-ORG Guangzhou I-ORG 201504010032 O and O the O Dongguan B-ORG City I-ORG Key I-ORG Program I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2014108101014 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O Guangdong B-ORG Natural I-ORG Science I-ORG Funds I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholar I-ORG 2015A030306030 O Special B-ORG Support I-ORG Program I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG of I-ORG Young I-ORG Talents I-ORG 2015TQ01N220 O Pearl B-ORG River I-ORG Nova I-ORG Program I-ORG of I-ORG Guangzhou I-ORG 201610010061 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 161gjc70 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31472301 O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31801745 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017M612889 O Chongqing B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Xm2017073 O Fundamental O Research O Funds O for O the O Central O Universities O XDJK2017C067 O XDJK2017C066 O and O National O Special O Research O Fund O for O Non-Profit O Sector O Agriculture O 201503107 O MT O acknowledges O the O support O of O the O American B-ORG Academy I-ORG of I-ORG Neurology/American I-ORG Brain I-ORG Foundation I-ORG Clinical B-AWARD Research I-AWARD Training I-AWARD Fellowship O 2015-2017 O YH O acknowledges O the O support O of O the O Muscular B-ORG Dystrophy I-ORG Association I-ORG MDA353094 O This O research O was O also O supported O by O the O National B-ORG Cancer I-ORG Institute O P30CA051008 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 41572150 B-AWARD Shandong B-ORG Province I-ORG Higher I-ORG Educational I-ORG Humanities I-ORG and I-ORG Social I-ORG Science I-ORG Program I-ORG Grant O No. O J18RA196 B-AWARD and O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Loess I-ORG and I-ORG Quaternary I-ORG Geology I-ORG Foundation I-ORG Grant O No. O SKLLQG2211 B-AWARD This O research O was O funded O by O Instituto B-ORG Milenio I-ORG iBio—Iniciativa I-ORG Científica I-ORG Milenio I-ORG MINECON I-ORG ANID/FONDECYT I-ORG 1171631 B-AWARD Andrea O Vega O 1180747 B-AWARD Claudia O Stange O and O by O the O Ramón B-ORG y I-ORG Cajal I-ORG program I-ORG grant I-ORG RYC-2017-23645 O awarded O to O José O Tomás O Matus O from O the O Ministerio O de O Ciencia O Innovación O y O Universidades O MCIU O Spain O Agencia O Estatal O de O Investigación O AEI O Spain O and O Fondo O Europeo O de O Desarrollo O Regional O FEDER O European O Union O Andrés O Leiva-Ampuero O and O Camila O Huidobro O were O supported O by O the O Agencia B-ORG Nacional I-ORG de I-ORG Investigación I-ORG y I-ORG Desarrollo I-ORG ANID O PhD O fellowship O no. O 21100365 B-AWARD and O 21191219 B-AWARD respectively O and O Mario O Agurto O was O supported O by O ANID/FONDECYT O postdoctoral O grant O number O 3190888 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG of I-ORG MOF I-ORG and I-ORG MARA I-ORG CARS36 O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 22022YFD1301003 O and O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG ASTIP-IAS12 O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31670716 O China B-ORG Postdoctoral I-ORG Science I-ORG Special I-ORG Foundation I-ORG 2016T90044 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2015M570945 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81501343 B-AWARD and O Bethune B-ORG plan I-ORG Project I-ORG of I-ORG Jilin I-ORG University I-ORG 2015410 O Jilin B-ORG Scientific I-ORG and I-ORG Technological I-ORG Development I-ORG Program I-ORG No. O 20170520010JH B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O CAPES B-ORG Finance O Code O 001 B-AWARD São B-ORG Paulo I-ORG Research I-ORG Foundation—FAPESP I-ORG grant O 2015/16934-8 B-AWARD and O Council B-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Development—CNPq I-ORG grants O 442822/2014-6 B-AWARD and O 305399/2015-2 B-AWARD The O research O was O supported O by O the O Polish B-ORG National I-ORG Centre I-ORG for I-ORG Research I-ORG and I-ORG Development O grant O no. O TECHMATSTRATEG-III/0005/2019-00 B-AWARD Computing O resources O were O provided O by O High-Performance B-ORG Computing I-ORG facilities I-ORG of I-ORG the I-ORG Interdisciplinary I-ORG Centre I-ORG for I-ORG Mathematical I-ORG and I-ORG Computational I-ORG Modeling I-ORG ICM I-ORG of I-ORG the I-ORG University I-ORG of I-ORG Warsaw I-ORG under O Grant O No. O GB79-16 B-AWARD and O Poznan B-ORG Supercomputing I-ORG and I-ORG Networking I-ORG Center I-ORG PSNC O under O Grant O No. O 482 B-AWARD This O work O was O supported O by O the O Wuxi B-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG Guiding I-ORG Topic I-ORG Grant O No. O CSZON1717 B-AWARD Youth B-ORG Project I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Research I-ORG Program I-ORG of I-ORG Wuxi I-ORG City I-ORG Grant O No. O Q201704 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81704033 B-AWARD This O research O was O funded O by O the O Frontier B-ORG Project I-ORG of I-ORG Wuhan I-ORG Applied I-ORG and I-ORG Basic I-ORG Research I-ORG grant O number O 2019020701011494 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 32172712 B-AWARD and O the O Key O R&D O Project O from O the O Department B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Hubei I-ORG Province I-ORG grant O number O 2020BBB070 B-AWARD The O APC O was O funded O by O the O National O Natural O Science O Foundation O of O China O This O study O was O supported O by O grants O from O Deutsche B-ORG Forschungsgemeinschaft I-ORG SA1360/9-1 O and O SA1360/7-3 B-AWARD Wilhelm B-ORG Sander-Stiftung I-ORG 2007.115.3 O Deutsche B-ORG Krebshilfe I-ORG 111828 O and O 70112914 B-AWARD and O Germany’s O Excellence O Strategy O EXC O 2180/1 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81530086 O 81673189 B-AWARD 81402686 O Ministry O of O Science O and O Technology O of O China O 2014CB943300 O the O Shanghai B-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG 15GWZK0401 O 201640363 B-AWARD Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG 14XD1403300 O and O the O Shanghai O Municipal O Education O Commission—Gaofeng O Clinical O Medicine O Grant O Support O 20172016 O The O funding O body O played O no O role O in O the O design O of O the O study O collection O analysis O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O supported O by O grants O from O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG for I-ORG Bast I-ORG and I-ORG Leaf I-ORG Fiber I-ORG Crops(No.CARS-16-E19 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.31772182 O The B-ORG Central I-ORG Government I-ORG Directs I-ORG Local I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Projects I-ORG 2019CT5009 B-AWARD The O projects O in O Liu O Lab O was O financially O supported O by O grants O from O the O State B-ORG Key I-ORG Project I-ORG of I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG 2021YFF1000400 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang O China O LD21C020001 O and O Zhejiang B-ORG Provincial I-ORG Talent I-ORG Program I-ORG 2019R52005 O This O work O was O supported O by O a O grant O from O the O Spanish B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Innovation I-ORG PID2020-112972RB-I00 B-AWARD a O grant O from O la O Fundació B-ORG La I-ORG Marató I-ORG TV3 I-ORG 202032 O and O a O grant O from O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG P01NS097197 B-AWARD which O established O the O Lafora O Epilepsy O Cure O Initiative O LECI O to O P.S O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 42201197 O the O Hebei B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG D2020205001 O and O the O Science B-ORG Foundation I-ORG of I-ORG Hebei I-ORG Normal I-ORG University I-ORG L2019B34 O Role O of O Funder O statement O All O of O these O funders O are O the O author O himself O of O the O article O because O the O author O is O the O head O of O the O three O projects O This O research O was O funded O by O the O Italian B-ORG Ministry I-ORG of I-ORG University I-ORG and I-ORG Research I-ORG PRIN2017 O Program O of I-ORG Relevant I-ORG National I-ORG interest-2017AY8BP4004 O to O F.C O and O by O the O Italian B-ORG Ministry I-ORG of I-ORG Health I-ORG Research I-ORG Program I-ORG RC2022-N4 O to O G.C O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grants O No. O 81472051 B-AWARD No. O 81601869 B-AWARD and O No.81772303 O Project B-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG Grant O No. O 15410722800 B-AWARD Project B-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Education I-ORG Commission I-ORG Gaofeng I-ORG Clinical I-ORG Medicine I-ORG Grant O No. O 20152529 B-AWARD and O Project B-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Grant O No. O 20154Y0027 B-AWARD This O research O was O funded O by O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG Southwest I-ORG Minzu I-ORG University I-ORG ZYN2023037 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2023NSFSC1200 O Open B-ORG Project I-ORG Program I-ORG of I-ORG Panxi I-ORG Crops I-ORG Research I-ORG and I-ORG Utilization I-ORG Key I-ORG Laboratory I-ORG of I-ORG Sichuan I-ORG Province I-ORG SZKF2217 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 22078111 O 21878105 B-AWARD This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0500706 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31801280 O and I-AWARD 31301832 O and O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M633039 O The O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O No. O 81672176 B-AWARD and O 81871783 B-AWARD the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG Central I-ORG South I-ORG University I-ORG grant O No. O 2020zzts288 B-AWARD and O the B-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG Human I-ORG Health I-ORG Committee I-ORG grant O No. O 20200357 B-AWARD This O work O was O supported O by O grants O from O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2015CB931800 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81773620 O 81573332 B-AWARD and O 31872746 B-AWARD Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Funds I-ORG 18431902800 O the O Scientific B-ORG Research I-ORG Projects I-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG 201740140 O This O research O is O funded O by O the O Major B-ORG project I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 41590841 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG No. O 2016YFC0503001 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Tianjin I-ORG China I-ORG No. O 18JCYBJC90900 B-AWARD and O the O Project B-ORG of I-ORG Scientific I-ORG Research I-ORG Plan I-ORG of I-ORG Tianjin I-ORG Education I-ORG Commission I-ORG No. O 2018KJ164 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O Grant O No. O 42101214 B-AWARD and O 41971216 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation O Grant O No. O 2021M703177 B-AWARD Hunan B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation O Grant O No. O 2022JJ30187 B-AWARD This O project O was O supported O by O the O Innovation B-ORG and I-ORG Technology I-ORG Commission I-ORG ITC-CNERC14SC01 O the O Research B-ORG Grant I-ORG Council I-ORG of I-ORG Hong I-ORG Kong I-ORG SAR I-ORG Project O Number O 16204815 B-AWARD NSFC-RGC B-ORG Joint I-ORG Research I-ORG Scheme I-ORG N_HKUST607/17 O This O work O was O supported O by O grants O from O the O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico—CNPq I-ORG #301869/2017-0—ACRV O 312979/2018-5—RI B-AWARD 314209/2021-2 B-AWARD Fundação B-ORG Amazônia I-ORG Paraense I-ORG de I-ORG Amparo I-ORG a I-ORG Estudos I-ORG e I-ORG Pesquisas I-ORG FAPESPA/PRONEX-060/2020 O and O Universidade B-ORG Federal I-ORG do I-ORG Pará I-ORG PAPQ/2019 O Funders O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O study O was O supported O by O grants O from O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O No. O 81860521 B-AWARD the O Jiangxi B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG 20192ACBL20022 O and O the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG the I-ORG Education I-ORG Department I-ORG of I-ORG Jiangxi I-ORG Province I-ORG 170116 O This O study O was O supported O by O Major B-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 32090023 B-AWARD The B-ORG key I-ORG program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG CAS O KJZD-SW-L11 B-AWARD National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2022YFC2601602 O Science B-ORG I-ORG Technology I-ORG Fundamental I-ORG Resources I-ORG Investigation I-ORG Program I-ORG 2022FY100903 O This O work O was O supported O by O the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 863 O Program O 2013AA102503 B-AWARD the O Program O for O Changjiang B-ORG Scholar I-ORG and I-ORG Innovation I-ORG Research I-ORG Team I-ORG in I-ORG University I-ORG IRT1191 O the O National B-ORG Natural I-ORG Science I-ORG Foundations I-ORG of I-ORG China I-ORG 31661143013 O 31790410 B-AWARD and O Kunming B-ORG Bureau I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Key I-ORG Program I-ORG 09H130302 O This O work O was O financially O supported O by O The B-ORG National I-ORG Natural I-ORG Science I-ORG Funds I-ORG of I-ORG China I-ORG 81803372 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG LY17H310008 O Key B-ORG Laboratory I-ORG of I-ORG Neuropsychiatric I-ORG Drug I-ORG Research I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2019E10021 O Doctoral B-ORG Fund I-ORG of I-ORG Zhejiang I-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG A11701Q O and O Health B-ORG Commission I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2019RC141 O XKQ-010–001 B-AWARD and O WJK-ZJ-1918 B-AWARD This O study O was O supported O by O the O Science B-ORG and I-ORG Technology I-ORG Foundation I-ORG of I-ORG Shenzhen I-ORG JCYJ20170307095620828 O and O JCYJ20160422145718224 B-AWARD and O the O Shenzhen B-ORG Urology I-ORG Minimally I-ORG Invasive I-ORG Engineering I-ORG Center I-ORG GCZX2015043016165448 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2018A030313743 O This O work O was O supported O by O the O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 7184192 B-AWARD and O 7162015 B-AWARD the O National O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 21778011 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG funded I-ORG project I-ORG No. O 2017M620567 O the O Beijing B-ORG Postdoctoral I-ORG Research I-ORG Foundation I-ORG No. O 2018-ZZ-022 O the O Chaoyang O District O Postdoctoral O Research O Foundation O No. O 2018ZZ-01-25 O the O Great O Wall O Scholars O Program O of O Beijing O Municipal O Education O Commission O No. O CIT&TCD20180308 O and O Education O Commission O Science O and O the O Technology O Project O of O Beijing O Municipality O No. O PXM2015_014204_500175 O The O study O has O been O funded O from O Medical B-ORG and I-ORG health I-ORG science I-ORG and I-ORG technology I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2019KY175 O 2018KY699 O Ningbo B-ORG Science I-ORG and I-ORG Technology I-ORG Huimin I-ORG Project I-ORG 2017C50070 O and O Ningbo B-ORG Clinical I-ORG Research I-ORG Center I-ORG for I-ORG Digestive I-ORG System I-ORG Tumors I-ORG Grant O No.2019A21003 O This O work O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31501669 O the B-ORG earmarked I-ORG fund I-ORG for I-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-01-36 O National B-ORG Special I-ORG Key I-ORG Project I-ORG of I-ORG China I-ORG 2016ZX08001-001 O and O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG LY15C140003 O This O study O is O supported O in O part O by O the O Young B-ORG Scientists I-ORG Foundation I-ORG of I-ORG China I-ORG NO. O 8501336 O Foundation B-ORG and I-ORG Cutting-edge I-ORG Research I-ORG Projects I-ORG of I-ORG Henan I-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG No. O 122300410400 O Oversea B-ORG Training I-ORG Projects I-ORG for I-ORG medical I-ORG academic I-ORG leaders I-ORG of I-ORG Henan I-ORG Province I-ORG No. O 2014089 O Medical B-ORG Science I-ORG and I-ORG Technology I-ORG research I-ORG projects I-ORG of I-ORG Henan I-ORG Provincial I-ORG Health I-ORG Bureau I-ORG No. O 201403180 O Scientific B-ORG and I-ORG Technological I-ORG projects I-ORG of I-ORG the I-ORG Technology I-ORG Bureau I-ORG of I-ORG Jinshui I-ORG District I-ORG No. O 38 O This O work O was O supported O by O the O Science O and O Technology O Research O Program O of O Chongqing B-ORG Municipal I-ORG Education I-ORG Commission I-ORG Grant O No. O KJQN201800609 B-AWARD and O Science O and O Technology O Research O Program O of O Chongqing B-ORG University I-ORG of I-ORG Posts I-ORG and I-ORG Telecommunications I-ORG Grant O No. O A2018-114 B-AWARD and O Chongqing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O No. O cstc2015jcyjA0752 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG LR14C160002 O the O National B-ORG High-Tech I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 863 O Program O 2013AA102605 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31170637 O the O Zhejiang O Provincial O New O Varieties O Breeding O Major O Agricultural O Science O and O Technology O Projects O 2012C12904 O and O the O Zhejiang O Forestry O of O Graduate O Innovation O Projects O Priority O Level O 201529 O The O funding O bodies O did O not O play O a O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O but O just O provide O the O financial O support O This O study O was O supported O by O grants O the B-ORG Youth I-ORG Elite I-ORG Training I-ORG Foundation I-ORG of I-ORG Harbin I-ORG Medical I-ORG University I-ORG Cancer I-ORG Hospital I-ORG JY2016-03 O the B-ORG Key I-ORG Projects I-ORG of I-ORG Haiyan I-ORG Foundation I-ORG of I-ORG Harbin I-ORG Medical I-ORG University I-ORG Cancer I-ORG Hospital I-ORG JJZD2019-02 O and O Outstanding B-ORG Youth I-ORG Programme I-ORG of I-ORG Harbin I-ORG Medical I-ORG University I-ORG Cancer I-ORG Hospital I-ORG JCQN2019-06 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 82173204 O 81772734 O the O Innovation B-ORG Capability I-ORG Support I-ORG Program I-ORG of I-ORG Shaanxi I-ORG 2020PT-021 O 2021TD-39 O the O Natural B-ORG Science I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG Shaanxi I-ORG 2022JZ-62 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG G2021KY05102 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31670978 O the O Fok B-ORG Ying I-ORG Tung I-ORG Education I-ORG Foundation I-ORG 132027 O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Fine I-ORG Chemicals I-ORG KF1111 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG DUT21YG113/DUT22YG213/DUT22YG116 O and O the O Basic B-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Major I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2020B1515120001 O This O research O was O funded O by O the O Guangxi B-ORG Innovation I-ORG Driven I-ORG Development I-ORG Special I-ORG Fund I-ORG Project I-ORG No. O AA20302018 B-AWARD the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC1604405 O the O Key B-ORG R&D I-ORG Program I-ORG of I-ORG Hunan I-ORG Province I-ORG 2020WK2017 O National B-ORG Tea I-ORG Industry I-ORG Technology I-ORG System I-ORG Research I-ORG Project I-ORG of I-ORG China I-ORG CARS-19-C01 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Project I-ORG of I-ORG China I-ORG 31471590 O 31100501 B-AWARD and O Self-Science B-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG China I-ORG 2019jj50237 O This O research O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Project O No: O 81971542 B-AWARD 82171771 I-AWARD 82171793 O 82271854 O 32230057 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Project O No: O BE2022766 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Higher I-ORG Education I-ORG Institutions I-ORG of I-ORG Jiangsu I-ORG Province I-ORG 22KJA310003 O and O Jiangsu O Provincial O Key O Medical O Center O This O work O was O supported O by O supported O by O Basic B-ORG Science I-ORG Foundation I-ORG of I-ORG Henan I-ORG University I-ORG of I-ORG Chinese I-ORG Medicine I-ORG No. O 2014KYYWF-QN26 B-AWARD Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Talent I-ORG Support I-ORG Scheme I-ORG of I-ORG Henan I-ORG University I-ORG of I-ORG Chinese I-ORG Medicine I-ORG No. O 2016XCXRC01 B-AWARD Scientific B-ORG and I-ORG Technological I-ORG Key I-ORG Project I-ORG in I-ORG Henan I-ORG Province I-ORG No.192102310438 O and O Research B-ORG Project I-ORG on I-ORG Chinese I-ORG Medicine I-ORG Science I-ORG in I-ORG Henan I-ORG Province I-ORG No. O 20-21ZY1039 B-AWARD This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82171898 O High-level B-ORG Hospital I-ORG Construction I-ORG Project I-ORG DFJH202109 O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangzhou I-ORG City I-ORG 202002030236 O Beijing B-ORG Medical I-ORG Award I-ORG Foundation I-ORG YXJL-2020-0941-0758 O and O CSCO-Hengrui B-ORG Cancer I-ORG Research I-ORG Fund I-ORG Y-HR2016-067 O The O funding O organizations O had O no O role O in O the O design O and O conduct O of O the O study O collection O management O analysis O and O interpretation O of O the O data O preparation O review O or O approval O of O the O manuscript O and O decision O to O submit O the O manuscript O for O publication O This O work O was O supported O by O a O research O grant O from O the O National B-ORG Institute I-ORG of I-ORG Health I-ORG NIH I-ORG the I-ORG National I-ORG Eye I-ORG Institute I-ORG NEI I-ORG United I-ORG States O Grant O 5R01EY026202 B-AWARD to O H.P.M O and O D.A.D O and O the O National B-ORG Institute I-ORG of I-ORG Dental I-ORG and I-ORG Craniofacial I-ORG Research I-ORG NIDCR O grant O R01DE031044 B-AWARD H.P.M O EY030447 B-AWARD CSDP O R01EY021517 B-AWARD R21EY032261 B-AWARD VIS O DOD B-ORG VRP I-ORG grant O VR2000079 B-AWARD VIS O This O research O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangxi I-ORG Zhuang I-ORG Autonomous I-ORG Region I-ORG No. O 2020GXNSFFA297005 B-AWARD the O Specific B-ORG Research I-ORG Project I-ORG of I-ORG Guangxi I-ORG for I-ORG Research I-ORG Bases I-ORG and I-ORG Talents I-ORG No. O AD21159002 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 32160220 B-AWARD and O 82160738 B-AWARD the O Development B-ORG Program I-ORG of I-ORG High-level I-ORG Talent I-ORG Team I-ORG under I-ORG the I-ORG Qihuang I-ORG Project I-ORG of I-ORG Guangxi I-ORG University I-ORG of I-ORG Chinese I-ORG Medicine I-ORG No. O 2021004 B-AWARD the O Special B-ORG Fund I-ORG for I-ORG Bagui I-ORG Scholars I-ORG of I-ORG Guangxi I-ORG No. O 05019055 B-AWARD and O the O Guangxi B-ORG University I-ORG of I-ORG Chinese I-ORG Medicine I-ORG “GuiPai I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG inheritance I-ORG and I-ORG innovation I-ORG team” I-ORG Project I-ORG No. O 2022A007 B-AWARD The O present O investigation O was O supported O by O “Science O and I-ORG Technology I-ORG Foundation I-ORG of I-ORG Huizhou I-ORG city I-ORG Guangdong I-ORG province” O No. O 2014B040008004 B-AWARD “Natural O Science I-ORG Foundation I-ORG of I-ORG Hu’nan I-ORG province” O No. O 2017JJ2050 B-AWARD and O No. O 2018JJ3572 O and O the O grant O of O Key B-ORG Laboratory I-ORG Breeding I-ORG Base I-ORG of I-ORG Hu’nan I-ORG Oriented I-ORG Fundamental I-ORG and I-ORG Applied I-ORG Research I-ORG of I-ORG Innovative I-ORG Pharmaceutics I-ORG No. O 2016TP1029 B-AWARD Hamadan B-ORG University I-ORG of I-ORG Medical I-ORG Sciences I-ORG Ethics O Committee O Code O IR.UMSHA.REC.1399.1077 O and O NO. O 140004012661 B-AWARD Water B-ORG and I-ORG Wastewater I-ORG Company I-ORG of I-ORG Kurdistan I-ORG NO. O 16.35.2697-1400.04.02 B-AWARD and O Iran B-ORG National I-ORG Science I-ORG Foundation I-ORG NO. O 4003096 B-AWARD are O our O financial O support O in O this O article O as O a O section O of O Ph.D O thesis O Great B-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Hangzhou O Award O Number O 20131812A02 B-AWARD O Recipient O Songlin O Ruan O Ph.DZhejiang O Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O Award O Number O LR12C13001 B-AWARD O Recipient O Songlin O Ruan O Ph.DOpen O Project I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Rice I-ORG Biology O Award O Number O 12020313 B-AWARD O Recipient O Shuzhen O Wang O This O work O is O supported O by O the O European B-ORG Union’s I-ORG Horizon I-ORG 2020 I-ORG research I-ORG and I-ORG innovation I-ORG programmes I-ORG SILICOFCM I-ORG Grant O agreement O 777204 B-AWARD and O SGABU B-ORG Grant O agreement O 952603 B-AWARD The O Commission O is O not O responsible O for O any O use O that O may O be O made O of O the O information O it O contains O The O research O was O also O funded O by O Serbian B-ORG Ministry I-ORG of I-ORG Education I-ORG Science I-ORG and I-ORG Technological I-ORG Development O grants O 451-03-47/2023-01/200378 O Institute O for O Information O Technologies O University O of O Kragujevac O and O 451-03-47/2023-01/200107 O Faculty O of I-ORG Engineering I-ORG University I-ORG of I-ORG Kragujevac O This O study O is O supported O and O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 71804094 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No.2016M592161 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG No. O ZR2016GB02 O Postdoctoral O Science O Foundation O of O Shandong O Province O No. O 201603021 O The O Fundamental O Research O Funds O of O Shandong O University O No. O 2015HW002 O No. O 2018JC055 O This O work O was O funded O by O Cooperative O Research O Program O for O Agriculture O Science O O Technology O Development O PJ010487 O from O the O Rural B-ORG Development I-ORG Administration I-ORG RDA O of O the O Republic O of O Korea O Medical B-ORG and I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2018KY505 O Wenzhou B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG Project O Y20180612 O The O founder O had O no O role O in O study O design O experiments O operation O data O collection O and O analysis O manuscript O preparation O or O decision O to O publish O J.G.B O acknowledges O the O Dutch B-ORG Research I-ORG Council I-ORG NWO O for O funding O through O the O Open O Technology O Programme O project O no. O 16361 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O numbers O 52125502 B-AWARD and O 52275323 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities O grant O numbers O FRFCU5710051121 B-AWARD and O FRFCU5720100421 B-AWARD This O research O was O funded O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82000899 O the O Research B-ORG Grant I-ORG of I-ORG Capital I-ORG Medical I-ORG University I-ORG PYZ21051 O and O Seed B-ORG Grant I-ORG Scheme I-ORG of I-ORG Beijing I-ORG Friendship I-ORG Hospital I-ORG YYZZ202025 O This O study O was O supported O in O part O by O grants O from O the O NPRCT-CU B-ORG P18-52505 O and O CPM-NSTDA B-ORG funding I-ORG program I-ORG P18-52112 O to O SW O and O from O the O Thailand B-ORG Research I-ORG Fund I-ORG Senior I-ORG Scholar I-ORG Grant I-ORG RTA6280010 B-AWARD given O to O SM. O This O research O was O supported O by O a O Discovery O grant O from O the O Australian B-ORG Research I-ORG Council's I-ORG Discovery I-ORG Project I-ORG funding I-ORG scheme I-ORG DP120100053 O to O Jolanda O Jetten O and O funding O from O the O Center B-ORG for I-ORG Social I-ORG Conflict I-ORG and I-ORG Cohesion I-ORG Studies I-ORG FONDAP O 15130009 O and O Anillos B-ORG CONICYT I-ORG SOC1103 O to O Roberto O González O This O work O was O financially O supported O by O the B-ORG National I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG No O 2015CB150200 B-AWARD the O National B-ORG System I-ORG of I-ORG Modern I-ORG Technology I-ORG for I-ORG Rapeseed I-ORG Industry I-ORG in I-ORG China I-ORG No O CARS-13 B-AWARD and O the O Core B-ORG Research I-ORG Budget I-ORG of I-ORG the I-ORG Non-profit I-ORG Governmental I-ORG Research I-ORG Institution I-ORG 161017 O FAR O and O PGC O acknowledge O support O the O Infect-ERA B-ORG IMI I-ORG European I-ORG network O program O “HantaHunt” O and O its O coordinator O Professor O Andreas O Herrmann O FAR O also O received O funding O from O the O Integrative B-ORG Biology I-ORG of I-ORG Emerging I-ORG Infectious I-ORG Diseases I-ORG Labex I-ORG Laboratoire I-ORG d'Excellence I-ORG grant O N° O ANR-10-LABX-62-IBEID B-AWARD French O Government's O “Investissements O d'Avenir” O program O ES O was O funded O as O “Experienced O Researcher” O ER) O by O the O Marie O Curie O Training O Network O “Virus O Entry” O Call:FP7-PEOPLE-2007-1-1-ITN O NDT O received O support O from O FONDECYT B-ORG 1140050 B-AWARD and O Basal O PFB-16 O grants O from O CONICYT O Chile O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O is O supported O by O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG CAAS-ASTIP-2016-ZFRI O to O JF, O the O Henan B-ORG Agriculture I-ORG Research I-ORG System I-ORG S2014-11 O to O JF, O and O the O Basic B-ORG Research I-ORG Fund I-ORG of I-ORG ZFRI I-ORG CAAS I-ORG 1610192017710 O to O MML O This O work O was O supported O by O the B-ORG Natural I-ORG Science I-ORG foundation I-ORG of I-ORG China I-ORG 41421061 O and O the B-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Cryosphere I-ORG Sciences I-ORG SKLCS-ZZ-2016 O This O work O was O also O supported O in O part O by O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 91547119 O and O the B-ORG Guizhou I-ORG Academy I-ORG of I-ORG the I-ORG Agricultural I-ORG Sciences I-ORG Foundation I-ORG [2016]0032 O ZW, O QW, O and O PW O were O affiliated O with O Guizhou O Science O and O technology O innovation O talents O team O Foundation O of O China O Qiankehepingtairencai O 2016]5617 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O grants O from O Interdisciplinary B-ORG Program I-ORG of I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG YG2017ZD07 O Shanghai B-ORG Outstanding I-ORG academic I-ORG leaders I-ORG plan I-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Committee I-ORG 18XD1402300 O and O Emerging B-ORG Frontier I-ORG Technology I-ORG Joint I-ORG Research I-ORG Program I-ORG of I-ORG Shanghai I-ORG Shen-Kang I-ORG Hospital I-ORG Development I-ORG Center I-ORG SHDC12015103 O This O work O of O Jun O Yong O Choi O was O supported O by O the O Research O Program O funded O by O the O Korea B-ORG Centers I-ORG for I-ORG Disease I-ORG Control I-ORG and I-ORG Prevention I-ORG 2019-ER5408-00 O research O grants O for O deriving O the O major O clinical O and O epidemiological O indicators O of O people O with O HIV O Korea O HIV/AIDS I-ORG Cohort I-ORG Study O 2019-ER5101-00 B-AWARD and O a O grant O from O the B-ORG Ministry I-ORG of I-ORG Health I-ORG I-ORG Welfare I-ORG Republic I-ORG of I-ORG Korea I-ORG grant O number O HI14C1324 B-AWARD The O work O of O Jeehyun O Lee O was O supported O by O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG grant O number O 2020R1A2C1A0101077511 B-AWARD and O Korea B-ORG Health I-ORG Industry I-ORG Development I-ORG Institute I-ORG grant O number O HG20C0003030020 B-AWARD This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0300700 O to O Chaoxi O Luo O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2662017JC003 O to O Chaoxi O Luo O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31701736 B-AWARD to O Weixiao O Yin O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O funds O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31430081 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2017YFD0500502 O Scientific O Research O Project O for O Major O Achievements O of O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG CAAS-ZDXT2019004 O and O Agricultural O Science O and O Technology O Innovation O Program O ASTIP-IAS12 O This O work O was O financially O supported O by O FONDEF B-ORG ID15I10576 B-AWARD Proyecto B-ORG Interno I-ORG Multidisciplinario I-ORG PIM_USM_12_18 B-AWARD 2018 O Fondecyt O Postdoctoral O N°3160568 O and O Millennium B-ORG Science I-ORG Initiative I-ORG P10-035F B-AWARD The O study O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC0910201 O the O Key B-ORG R&D I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2019B020226001 O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG 2015BAI07B01 O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangzhou I-ORG 201704020176 O 201508020040 B-AWARD 201510010044 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2015ZZ125 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31471288 O to O N.Y O 31471343 B-AWARD to O T.W.-M O the O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG CIFMS O 2016-I2M-1004 O to O N.Y O and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 33320140041 O to O N.Y O 2014199 B-AWARD to O T.W.-M O This O work O was O supported O by O the O New B-ORG York I-ORG State I-ORG Department I-ORG of I-ORG Environmental I-ORG Conservation I-ORG under O MOU O AM10700 B-AWARD to O the O Research O Foundation O of O the O State O University O of O New O York O G.L.B O and O the O National B-ORG Science I-ORG Foundation I-ORG Award O IOS-1451528 O to O G.L.B O This O work O was O partially O supported O by O funding O from O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG 1P01ES028939-01 O and O National O Science O Foundation O OCE-1840715 O to O the O Bowling O Green O State O University O Lake O Erie O Center O for O Fresh O Waters O and O Human O Health O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81800809 O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG of I-ORG Zhejiang I-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Hall I-ORG 2017C03046 O Medical B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2018261846 O General B-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG Education I-ORG Department I-ORG Y201738741 O This O research O was O funded O by O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo I-ORG 2017/27265-5 O and O 2018/21460-3)http://www.fapesp.br B-AWARD Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq O 429594/2018-6)http://www.cnpq.br O and O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG CAPES O 88887.177846/2018-00)https://www.capes.gov.br O AMR O is O a O CNPq B-ORG Research I-ORG Productivity I-ORG Fellow I-ORG CNPq O 304902/2020-9 O This O research O received O joint O support O from O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2016YFC0502001 O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG XDB03030401 O and O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDA19050502 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Emergency B-ORG Novel I-ORG Coronavirus I-ORG Pneumonia I-ORG Project I-ORG from I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2020YFC0844700 O the O Emergency B-ORG Project I-ORG from I-ORG Chongqing I-ORG Health I-ORG Commission I-ORG 2020NCPZX01 O and O the O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG Chongqing I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG CSTC2017JCYJ-YSZXX0012 O CSTC2018JCYJAX0538 B-AWARD and O CXQT19013 B-AWARD This O research O and O the O APC O were O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 21176187 B-AWARD the O Integration O Development O Project O of O Shandong O University O of O Technology O and O Zibo O City O Joint O Research O and O Development O Program O of O Zibo O City O SDUT O 2016ZBXC190 O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG Public O Welfare O Project O 2017GGX20133 B-AWARD the O Research B-ORG Fund I-ORG for I-ORG the I-ORG Doctoral I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG of I-ORG China I-ORG RFDP O 20171201110007 B-AWARD and O the O support O from O Xingzhixuan O Technology O S.Z O Co O LTD O Financial O support O from O Fundação B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG Tecnologia I-ORG FCT)/MCTES I-ORG through O national O funds O to O Applied O Molecular O Biosciences O Unit O UCIBIO O UIDP/04378/2020 B-AWARD and O the O project O LA/P/0140/2020 B-AWARD of O Associate B-ORG Laboratory I-ORG Institute I-ORG for I-ORG Health I-ORG and I-ORG Bioeconomy I-ORG i4HB O and O the O PhD O grant O 2021.06472.BD O from O FCT O for O Carina O Brito O This O work O was O funded O by O grants O from O Cancer B-ORG Research I-ORG Wales I-ORG 506719 O the O Wellcome B-ORG Trust I-ORG 504182 O Cancer B-ORG Research I-ORG UK I-ORG C16731/A21200 O and O internal O funding O from O Cardiff O University O Funding O bodies O supported O the O idea O of O this O study O but O were O not O involved O in O collection O analysis O or O interpretation O of O data O Nor O were O they O involved O in O the O writing O of O this O manuscript O This O work O was O supported O by O the O Guangzhou B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG No. O 201803010046 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81672232 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2015B020233013 B-AWARD This O research O was O funded O by O the O Tianyuan B-ORG Fund I-ORG for I-ORG Mathematics I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 12226333 B-AWARD the O National O Natural O Science O Foundation O of O China O Grant O No.12201454 O and O the O Natural B-ORG Science I-ORG and I-ORG Engineering I-ORG Research I-ORG Council I-ORG of I-ORG Canada I-ORG RGPIN-2017-05720 O This O research O work O has O been O made O possible O thanks O to O financing O from O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 52002144 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51872120 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2020QE046 O and O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFB0309905 B-AWARD This O work O was O supported O by O the O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG N/A O Integra B-ORG Codman I-ORG Surgical I-ORG Specialties I-ORG HM202110 O Wellcome B-ORG Trust I-ORG 203139/Z/16/Z O This O work O was O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG No. O 2016J05145 B-AWARD Open B-ORG Fund I-ORG of I-ORG Key I-ORG Laboratory I-ORG of I-ORG Hunan I-ORG Province I-ORG for I-ORG Mobile I-ORG Business I-ORG Intelligence I-ORG No. O 2015TP1002 B-AWARD Program B-ORG for I-ORG New I-ORG Century I-ORG Excellent I-ORG Talents I-ORG in I-ORG Fujian I-ORG Province I-ORG University I-ORG No. O GY-Z18155 B-AWARD Program B-ORG for I-ORG Outstanding I-ORG Young I-ORG Scientific I-ORG Researcher I-ORG in I-ORG Fujian I-ORG Province I-ORG University I-ORG No. O GY-Z160149 B-AWARD and O Scientific B-ORG Research I-ORG Foundation I-ORG of I-ORG Fujian I-ORG University I-ORG of I-ORG Technology I-ORG No. O GY-Z17162 B-AWARD This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O no. O 61601104 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG Grant O no. O F2017501052 B-AWARD and O the B-ORG Basic I-ORG Science I-ORG Research I-ORG Fund I-ORG of I-ORG Northeast I-ORG University I-ORG at I-ORG Qin I-ORG Huang I-ORG Dao I-ORG Grant O no. O XNB201611 B-AWARD This O research O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31471768 O the O Jiangsu B-ORG Agriculture I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Fund I-ORG CX(15)1053 O and O the O Grain B-ORG High I-ORG Yield I-ORG and I-ORG High I-ORG Efficiency I-ORG Technology I-ORG Innovation I-ORG Program I-ORG 2016YFD0300706 O These O funding O bodies O had O no O role O in O design O collection O and O analysis O of O the O study O and O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 81400212 B-AWARD Chongqing B-ORG Basic I-ORG and I-ORG Frontier I-ORG Research I-ORG Project I-ORG No. O CSTC2018jcyjAX0126 B-AWARD and O Chongqing B-ORG Teenagers I-ORG Innovative I-ORG Talent I-ORG Training I-ORG Program I-ORG No. O CY190401 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.21475097 O and I-AWARD 21471116 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG LY17B050004 O LY18H200025 I-AWARD and I-AWARD LY17E020003 O and O the O Opening B-ORG Project I-ORG of I-ORG Zhejiang I-ORG Provincial I-ORG Top I-ORG Key I-ORG Discipline I-ORG of I-ORG Clinical I-ORG Medicine I-ORG KFJ026 O This O work O was O funded O by O the O National B-ORG Food I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG Grant O 2017YFD0300106 B-AWARD and O 2016YFD0300208 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31561143003 B-AWARD and O 31671619 B-AWARD Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG China I-ORG LQ18C130003 O This O research O was O funded O by O the O Special B-ORG Basic I-ORG Cooperative I-ORG Programs I-ORG of I-ORG Yunnan I-ORG Provincial I-ORG Undergraduate I-ORG Universities’ I-ORG Association I-ORG 202101BA070001-154 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 42267051 O and O the O Undergraduate B-ORG Training I-ORG Program I-ORG on I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG S202211393056 O 202011393007 B-AWARD 202011393016 B-AWARD This O work O was O supported O by O grants O from O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG No. O XDB11010400 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 31572277 B-AWARD and O 31672306 B-AWARD and O the O Foundation B-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG IPM I-ORG ChineseIPM1701 O This O study O was O supported O by O a O grant O from O the O Hangzhou B-ORG health I-ORG science I-ORG and I-ORG technology I-ORG plan I-ORG Major I-ORG project I-ORG 2015ZD01 O Zhejiang B-ORG medical I-ORG and I-ORG health I-ORG science I-ORG and I-ORG technology I-ORG project I-ORG 2016ZDB011 O Zhejiang B-ORG basic I-ORG public I-ORG welfare I-ORG research I-ORG project I-ORG LGF18H160037 O We O gratefully O acknowledge O the O Heilongjiang O Provincial O Key O Laboratory O of O Plant O Genetic O Engineering O and O Biological O Fermentation O Engineering O for O Cold O Region O to O carry O out O this O work O This O work O was O supported O in O part O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC1000402 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81571445 O 81771617 I-AWARD 31771000 O Key O Project O of O Natural O Science O Foundation O of O China O 81830041 O Shenzhen O Basic O Research O Fund O JCYJ20170817143406822 O Excellent O Youth O Natural O Science O Foundation O of O Heilongjiang O Province O of O China O JC2018008 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2016A030313178 O Shenzhen O Basic O Research O Fund O JCYJ20170413165233512 O JCYJ20170817143406822 O and O Shenzhen O Peacock O Technology O Innovation O Project O KQJSCX20170331161310587 O This O work O was O supported O by O the O Basic O Science O Research O Program O through O the O National O Research O Foundation O of O Korea O funded O by O the O Ministry B-ORG of I-ORG Education I-ORG Science I-ORG and I-ORG Technology I-ORG NRF-2015R1A2A1A15053987 O This O study O was O provided O with O biospecimens O and O data O from O the O Korean B-ORG Genome I-ORG Analysis I-ORG Project I-ORG 4845-301 O the O Korean B-ORG Genome I-ORG and I-ORG Epidemiology I-ORG Study I-ORG 4851-302 O and O Korea B-ORG Biobank I-ORG Project I-ORG 4851-307 O KBP-2015-035 B-AWARD which O are O supported O by O the O Korea O Center O for O Disease O Control O and O Prevention O Republic O of O Korea O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFD0500105 O the B-ORG Yunnan I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG No. O 2018BB004 O and O the B-ORG Promotion I-ORG Project I-ORG of I-ORG ESI I-ORG Disciplines I-ORG of I-ORG YAU I-ORG No. O 2019YNAUESIMS03 B-AWARD The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O a O fund O of O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O 31701401 B-AWARD a O fund O of O Zhejiang B-ORG Province I-ORG Public I-ORG Welfare I-ORG Technology I-ORG Application I-ORG Research I-ORG Project I-ORG LGN19C130005 O and O a O fund O from O the B-ORG State I-ORG Key I-ORG Laboratory I-ORG for I-ORG Conservation I-ORG and I-ORG Utilization I-ORG of I-ORG Subtropical I-ORG Agro-bioresources I-ORG SKLCUSA-b201713 O The O funding O bodies O did O not O play O any O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O grants O from O the O National B-ORG Science I-ORG Council I-ORG Taiwan I-ORG NSC O 101-2313-B-003-002-MY3 O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Taiwan I-ORG MOST O 106-2320-B-003-006-MY3 B-AWARD MOST I-AWARD 107-2320-B-003-002-MY2 I-AWARD and I-AWARD MOST I-AWARD 107-2320-B-010-040-MY3 O and O National B-ORG Taiwan I-ORG Normal I-ORG University I-ORG 10403 O 10502 I-AWARD and I-AWARD 10602 O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31172001 O the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-25 O the O Special B-ORG Fund I-ORG for I-ORG Agro-Scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG of I-ORG China I-ORG 201303014 O and O the O Science B-ORG and I-ORG Technological I-ORG Innovation I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG CAAS-ASTIP-IVFCAAS O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 22164002 B-AWARD No. O 22104014 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Province I-ORG 20212BAB20213003 O and O the O Key B-ORG Project I-ORG at I-ORG the I-ORG Central I-ORG Government I-ORG Level O the O ability O establishment O of O sustainable O use O for O valuable O Chinese O medicine O resources O No. O 2060302 B-AWARD This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFD0500805 B-AWARD the B-ORG Shanghai I-ORG Key I-ORG Project I-ORG on I-ORG Agricultural I-ORG Development I-ORG through I-ORG Science I-ORG and I-ORG Technology I-ORG 2016HNG4-1 O and O Co-innovation B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG in I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG CAAS-XTCX2016011-04-8 O This O work O was O supported O by O The O Netherlands B-ORG organization I-ORG for I-ORG health I-ORG research I-ORG and I-ORG development I-ORG NWO O VENI O grant O 91619059 B-AWARD by O ITEA B-ORG 3 I-ORG Call I-ORG 4 I-ORG IMPACT O grant O number O 17021 B-AWARD and O by O the O Industrial B-ORG research I-ORG fund I-ORG of I-ORG the I-ORG Vrije I-ORG Universiteit I-ORG Brussel I-ORG IOF3005 O This O research O was O supported O by O the O São B-ORG Paulo I-ORG Research I-ORG Foundation I-ORG FAPESP O 2020/15237-0 O granted O to O I.F.R O 21/06742-5 B-AWARD granted O to O R.H.N O 2020/05761-3 O granted O to O G.M O 2018/07098-0 B-AWARD and O 2019/19939-1 B-AWARD granted O to O I.C-S O 2014/04294-1 B-AWARD granted O to O C.R.G O 2014/04294-1 O granted O to O G.G O and O 2019/21739-0 B-AWARD granted O to O C.G.B O The O authors O acknowledge O the O financial O support O from O CAPES B-ORG Grant O no O 88887.504531/2020-00 B-AWARD from O notice O n° O 09/2020 O to O CNPq O INCTBio O grant O no. O 465389/2014-7 B-AWARD to O Medical O School O Foundation O for O financial O support O Project O CG I-AWARD 19,110 O and O to O Rede O Virus O MCTI O grant O FINEP O 0459/20 B-AWARD G.M O and O LJGB O were O awarded O productivity O scholarships O from O the O Brazilian B-ORG National I-ORG Council I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Development I-ORG CNPq O proc O nos O 426531/2018-3 B-AWARD and O 307743/2018-7 B-AWARD 303263/2018-0 B-AWARD respectively O This O study O was O funded O by O Competence B-ORG Network I-ORG for I-ORG Congenital I-ORG Heart I-ORG Defects I-ORG Nr. O 01GI0601 I-AWARD 2014 O to O HA-K O German B-ORG Centre I-ORG for I-ORG Cardiovascular I-ORG Research I-ORG DZHK O Nr. O 81X2800112 B-AWARD 2015 O to O H-AK O and O Hedwig-Stalter-Stiftung B-ORG 2016 O to O MA-H O This O work O is O supported O by O Suzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG Li O Huang O Grant O Number O SYS201558 B-AWARD The B-ORG project I-ORG of I-ORG Jiangsu I-ORG Provincial I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Li O Huang O Grant O Number O H201622 B-AWARD The B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Wei O Ji, O Grant O Number O 81570016 B-AWARD Zhengrong O Chen O Grant O Number O 81401296 B-AWARD We O wish O to O acknowledge O the O financial O support O of O the O following O agencies O Fondation B-ORG pour I-ORG la I-ORG Recherche I-ORG Médicale I-ORG FRM O grant O number O DIC20161236442 B-AWARD European B-ORG Commission's I-ORG Human I-ORG Brain I-ORG Project I-ORG grant O agreement O H2020-720270 B-AWARD and O the O SATT B-ORG Sud-Est I-ORG TVB-Epilepsy O for O providing O funding O for O this O research O project O Our O work O has O been O carried O out O within O the O FHU O EPINEXT O with O the O support O of O the O A*MIDEX O project O ANR-11-IDEX-0001-02 O funded O by O the O Investissements O d'Avenir O French O Governement O program O managed O by O the O French B-ORG National I-ORG Research I-ORG Agency I-ORG ANR O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Shandong B-ORG Medical I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Programs I-ORG No. O 2018WS309 O to O YF, O Taishan B-ORG Scholar I-ORG Program I-ORG of I-ORG Shandong I-ORG Province(No O tstp20221164 O to O LZ, O ZhiFei B-ORG Disease I-ORG Prevention I-ORG and I-ORG Control I-ORG Technology I-ORG Research I-ORG Fund I-ORG Project I-ORG No. O LYH2017-08 O to O YF, O Science B-ORG and I-ORG Technology I-ORG Project I-ORG for I-ORG the I-ORG Universities I-ORG of I-ORG Shandong I-ORG Province I-ORG No. O J18KB171 O to O YG, O and O Shandong B-ORG Women’s I-ORG University I-ORG High I-ORG level I-ORG scientific I-ORG research I-ORG project I-ORG Cultivation I-ORG Fund I-ORG No. O 2020GSPGJ08 O to O YG. O YF: O Conceptualization O Data O curation O Methodology O Writing O original O draft O LZ: O Data O curation O Writing O review O and O editing O YG: O Conceptualization O Methodology O Writing O review O and O editin O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 31300285 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG grant O number O 2015J01348 B-AWARD as O well O as O the O Specialized B-ORG Research I-ORG Fund I-ORG for I-ORG the I-ORG Doctoral I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG grant O number O 20110073120072 B-AWARD Fujian O Province O Development O Guidance O Key O Project O grant O number O 2014Y0074 O and O the O Educational O and O Scientific O Research O Project O for O Young O and O Middle-aged O Teachers O of O Fujian O Province O grant O number O JT180012 O This O work O was O supported O by O the O Guangdong B-ORG Provincial I-ORG Academician I-ORG Workstation I-ORG of I-ORG BGI I-ORG Synthetic I-ORG Genomics I-ORG No. O 2017B090904014 B-AWARD Guangdong B-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Genome I-ORG Read I-ORG and I-ORG Write I-ORG No. O 2017B030301011 B-AWARD and O Shenzhen B-ORG Engineering I-ORG Laboratory I-ORG for I-ORG Innovative I-ORG Molecular I-ORG Diagnostics I-ORG DRC-SZ[2016]884 O This O study O was O financially O supported O by O grants O from O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81600362 O Beijing B-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospitals’ I-ORG Youth I-ORG Programme I-ORG QML20170602 O and O The B-ORG Capital I-ORG Health I-ORG Research I-ORG and I-ORG Development I-ORG of I-ORG Special I-ORG 2018-2-2-66 O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31772763 O 31702266 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Gansu I-ORG Province I-ORG 18JR3RA400 O 1606RJYA256 O the O Central O Public-interest O Scientific O Institution O Basal O Research O Fund O 1610312016018 O 1610312016016 O and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0501104 O 2017YFD0500902 I-AWARD 2016YFD0501504 O This O study O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2022YFC2405600 O NSFC B-ORG 81871444 O 62071241 B-AWARD 62075098 B-AWARD 62001240 B-AWARD the O Leading-edge B-ORG Technology I-ORG and I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG Jiangsu I-ORG BK20192004D O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Jiangsu I-ORG BE2022160 O and O the O Postgraduate B-ORG Research I-ORG and I-ORG Practice I-ORG Innovation I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG KYCX22_1779 O This O study O was O supported O by O a O grant O HI13C0016 O awarded O to O Youngnim O Choi O from O the O Korea B-ORG Health I-ORG Industry I-ORG Development I-ORG Institute I-ORG and O a O grant O 2016R1E1A1A01942402 O awarded O to O Youngnim O Choi O from O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea O Labial O salivary O gland O biopsy O specimens O used O in O this O manuscript O are O from O the O Sjögren’s O International O Collaborative O Clinical O Alliance O SICCA O funded O under O contract O N01 B-AWARD DE-32636 I-AWARD by O the O National B-ORG Institute I-ORG of I-ORG Dental I-ORG and I-ORG Craniofacial I-ORG Research O with O funding O support O from O the O National O Eye O Institute O and O the O Office O for O Research O in O Women’s O Health O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financed O by O Portuguese O National O Funds O through O FCT—Portuguese B-ORG Foundation I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG grant O no. O UIDB/50006/2020 B-AWARD and O by O the O project O cLabel B-ORG POCI-01-0247-FEDER-046080 O Maria O Lopes O would O also O like O to O acknowledge O FCT O for O supporting O the O present O research O through O the O Ph.D O grant O 2020/04738/BD B-AWARD This O research O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 62006008 B-AWARD 62173007 B-AWARD Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 6214034 B-AWARD and O MOE B-ORG Ministry O of O Education O in O China O Project O of O Humanities O and O Social O Sciences O No. O 19YJC790028 B-AWARD 22YJCZH006 B-AWARD This O research O was O funded O by O the B-ORG Young I-ORG Talents I-ORG Projects I-ORG of I-ORG the I-ORG Institute I-ORG of I-ORG Urban I-ORG Environment I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG IUEMS201402 O the O International O regional O cooperation O and O exchange O programs O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC-JPI_UE O 7181101187 O the O National O Natural O Science O Foundation O of O China O 71704171 O and O the B-ORG National I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2014CB953801 O S.G.L O acknowledges O the O support O of O NSFC B-ORG through O Grants O 41472130 O and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2016YFC0600704 B-AWARD C.W O acknowledges O the O support O of O NSFC O through O Grants O 11972348 O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Grant O No. O XDB22040503 B-AWARD M.Q.J O acknowledges O the O support O of O NSFC O through O Grants O 12125206 O This O research O was O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0201001 O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-23-B02 O and O the B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG China I-ORG 2017CXGC0206 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O China B-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Projects I-ORG Foundation O grant O number O 2017ZX10303406 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation O grant O number O 2020T130082ZX B-AWARD Sanming B-ORG Project I-ORG of I-ORG Medicine I-ORG in I-ORG Shenzhen O grant O number O SZSM201811071 B-AWARD Beijing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Project O grant O number O Z201100001020004 B-AWARD Shenzhen B-ORG Committee I-ORG of I-ORG Scientific I-ORG and I-ORG Technical I-ORG Innovation I-ORG grant O grant O number O JCYJ20180508152244835 B-AWARD Shenzhen B-ORG Key I-ORG Medical I-ORG Discipline I-ORG Construction I-ORG Fund O grant O number O SZXK064 B-AWARD Special B-ORG Foundation I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Strategy I-ORG of I-ORG Guangdong I-ORG Province I-ORG of I-ORG China O grant O number O 2020B1111340077 B-AWARD This O work O was O supported O by O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O grants O funded O by O the O Korea O Government O Ministry O of O Science O and O ICT O NRF-2015M3C7A1028790 O NRF-2018R1C1B6001235 B-AWARD and O NRF-2018M3C7A1024603 B-AWARD by O the O Korea B-ORG Institute I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Information I-ORG K-18-L12-C08-S01 O and O by O Korea B-ORG University I-ORG Future B-AWARD Research I-AWARD Grant I-AWARD K1824021 I-AWARD This O work O was O supported O by O grants O of O RH B-ORG Forskningspulje I-ORG R143-A6132-B3632 O to O Dr. O Daniel O Kondziella O and O the O Deutsche B-ORG Forschungsgemeinschaft I-ORG DFG O DFG B-AWARD DR I-AWARD 323/5-1 I-AWARD and O DFG B-AWARD DR I-AWARD 323/10-1 O and O FP7 B-ORG no O 602150 B-AWARD CENTER-TBI O to O Dr. O Jens O P. O Dreier O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC1305500 O and I-AWARD 2016YFC1305404 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 61471399 I-AWARD and I-AWARD 61671479 O National B-ORG Clinical I-ORG Research I-ORG Center I-ORG for I-ORG Kidney I-ORG Disease I-ORG No. O 2013BAI09B05 O the O Key B-ORG Program I-ORG of I-ORG Joint I-ORG Funds I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O U1604284 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Henan I-ORG province I-ORG No. O 162300410282 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National O Key O R&D O Program O of O China O No. O 2016YFD0400203 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31671881 B-AWARD 31901683 O 31972102 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG XDJK2019B028 O Chongqing B-ORG Research I-ORG Program I-ORG of I-ORG Basic I-ORG Research I-ORG and I-ORG Frontier I-ORG Technology I-ORG No. O cstc2018jcyjA0939 B-AWARD Hongping O Qu O is O supported O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG grant O number O 2017YFC1309705 B-AWARD Jialin O Liu O is O supported O by O the O Medical-engineering B-ORG Cross I-ORG Fund I-ORG of I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG grant O number O YG2014MS58 B-AWARD and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG grant O number O 16ZR1420900 B-AWARD and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81770005 B-AWARD Jieming O Qu O is O supported O by O Shanghai B-ORG Key I-ORG discipline I-ORG for I-ORG respiratory I-ORG diseases I-ORG grant O number O 2017ZZ02014 B-AWARD This O work O was O supported O by: O Consejo B-ORG Nacional I-ORG de I-ORG Investigaciones I-ORG Científicas I-ORG y I-ORG Técnicas I-ORG CONICET I-ORG PIP2015-0595CO O Agencia B-ORG Nacional I-ORG de I-ORG Promoción I-ORG Científica I-ORG y I-ORG Tecnológica I-ORG ANPCyT I-ORG PICT2014-1672 O and O UBACyT B-ORG 20020130100505BA O 2014-2017 O the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC1305000 O 2016YFC1305001 I-AWARD and I-AWARD 2018YFC1315603 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81820108007 O and O Hainan B-ORG Provincial I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG ZDYF2018130 O This O work O was O supported O by O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG CAPES O grant O number O 3325/2013 B-AWARD finance O code O 001 O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq O grant O numbers O 309046/2016-5 B-AWARD and I-AWARD 305676/2019-9 O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG e I-ORG ao I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG do I-ORG Maranhão I-ORG FAPEMA O grant O number O 03207/18 B-AWARD and O INCT-INOVAMED B-ORG grant O number O 465430/2014-7 B-AWARD J.P.P O and O N.C.F.S O are O students O receiving O grants O from O FAPEMA O L.F.G O is O an O undergraduate O student O receiving O a O grant O from O CNPq O D.M.S O is O an O undergraduate O student O receiving O a O grant O from O the O Santander O Universidades O programme O A.R.C.Jr O and O N.M.T.O O are O PhD O students O receiving O grants O from O Fundação O de O Amparo O à O Pesquisa O do O Estado O de O São O Paulo O FAPESP O and O CAPES O respectively O B.C.d.S O is O a O MSc O student O receiving O a O studentship O from O Instituto O de O Pesquisa O Pelé O Pequeno O Príncipe O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51862010 O the O Guangdong B-ORG Provincial I-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG of I-ORG China I-ORG 2019A1515110934 O and O 2019A1515110370 B-AWARD the B-ORG Guangdong I-ORG Provincial I-ORG Education I-ORG Department I-ORG Special I-ORG Project I-ORG of I-ORG Key I-ORG Research I-ORG Areas I-ORG 2020ZDZX2066 O the B-ORG Innovation I-ORG Team I-ORG of I-ORG Universities I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2020KCXTD011 O the B-ORG Engineering I-ORG Research I-ORG Center I-ORG of I-ORG Universities I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2019GCZX002 O the O Guangdong O Key O Laboratory O for O Hydrogen O Energy O Technologies O 2018B030322005 O and O the B-ORG Key I-ORG Project I-ORG of I-ORG Guangdong I-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG 2020B1515120081 O for O financial O supports O This O work O was O supported O by O the B-ORG Military I-ORG logistics I-ORG Research I-ORG Project I-ORG number O CWH17C017 B-AWARD to O Linhai O Li O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou O China O number O 201804010186 B-AWARD to O Bin O Xiao O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O China O number O 2018A030310014 B-AWARD to O Bin O Xiao O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O number O 81802634 B-AWARD to O Bin O Xiao O No O specific O funding O was O received O for O this O study O This O research O was O supported O by O the O NIHR O Oxford O Health O Biomedical O Research O Centre O a O Wellcome B-ORG Trust I-ORG Strategic O Award O Grant O 098369/Z/12/Z B-AWARD Wellcome O Investigator O Awards O to O MWW O 106183/Z/14/Z O and O ACN O 104571/Z/14/Z O and O a O James B-ORG S. I-ORG McDonnell I-ORG Foundation I-ORG Understanding O Human O Cognition O Collaborative O Award O 220020448 O The O Wellcome O Centre O for O Integrative O Neuroimaging O is O supported O by O core O funding O from O the O Wellcome O Trust O 203139/Z/16/Z O MB O is O supported O by O the O UK O Quantum O Technology O Hub O for O Sensors O and O Metrology O funded O by O the O Engineering B-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG EPSRC O EP/M013294/1 O ZAS O is O supported O by O a O studentship O from O the O Oxford O Nottingham O Biomedical O Imaging O Centre O for O Doctoral O Training O Centre O EPSRC/MRC O O EP/L016052/1 O The O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFB1103300 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51975320 O and O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG M22011 O supported O this O work O This O work O was O supported O by O The B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0901500 O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences O CIFMS O 2017-I2M-3-001 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81771757 O 81571587 B-AWARD and O 81601433 B-AWARD This O work O was O partially O supported O by O the O JSPS B-ORG Moonshot I-ORG R&D I-ORG Grant O Number O JPMJMS2021 B-AWARD the O JSPS B-ORG Core-to-Core I-ORG Program I-ORG JPJSCCA20170004 B-AWARD and O the O KAKENHI B-ORG Grant O Numbers O 18KK0110 B-AWARD and O 20J01391 B-AWARD This O work O was O supported O by O the B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG the I-ORG Health I-ORG department I-ORG of I-ORG Sichuan I-ORG 120326 O Collaborative B-ORG Fund I-ORG of I-ORG Luzhou I-ORG Government I-ORG and I-ORG Southwest I-ORG Medical I-ORG University I-ORG 2018LZXNYD-ZK29 O Collaborative B-ORG Fund I-ORG of I-ORG Luzhou I-ORG Government I-ORG and I-ORG Sichuan I-ORG Medical I-ORG University I-ORG 2015SX-W35 O the B-ORG Youth I-ORG Fund I-ORG of I-ORG Southwest I-ORG Medical I-ORG University I-ORG 2017-ZRQN-103 O the B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG the I-ORG Health I-ORG Planning I-ORG Committee I-ORG of I-ORG Sichuan I-ORG 18PJ340 O the O Ph.D O Research B-ORG Fund I-ORG of I-ORG the I-ORG Affiliated I-ORG Hospital I-ORG of I-ORG Southwest I-ORG Medical I-ORG University I-ORG 16237 O The O recipients O of O the O fund O Changfeng O Sun O revised O the O manuscript O and O Gang O WU O designed O the O study O constructed O the O framework O and O revised O the O manuscript O This O work O was O supported O by O the O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31572094 O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG CAAS-ASTIP-2018-ZFRI-01 O Crop B-ORG Germplasm I-ORG Resources I-ORG Conservation I-ORG Project I-ORG 2016NWB041 O and O the O US O National B-ORG Science I-ORG Foundation I-ORG IOS-1339287 O and O IOS-1539831 B-AWARD This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51675518 B-AWARD Six B-ORG Talent I-ORG Peaks I-ORG Project I-ORG in I-ORG Jiangsu I-ORG Province I-ORG No. O JXQC-008 B-AWARD China B-ORG Scholarship I-ORG Council I-ORG No. O 201706425041 B-AWARD and O the O Priority O Academic O Program O Development O of O Jiangsu O Higher O Education O Institutions O This O paper O is O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 81370326 B-AWARD 81641005 B-AWARD Beijing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG Z181100001718200 O and O National B-ORG Precision I-ORG Medical I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0905602 O The O study O design O was O supported O by O the O 111 B-ORG project I-ORG No:B08006 O The O data O collection O and O analysis O was O supported O by O a O grant O from O 111 O project O No: O B08006 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grants O number O 81473518 B-AWARD 81573824 B-AWARD the O Capital B-ORG Health I-ORG Research I-ORG and I-ORG Development I-ORG of I-ORG Special I-ORG grants O number O SF2016–4-4193 B-AWARD The O interpretation O of O data O and O in O writing O the O manuscript O was O supported O by O the O 111 O project O No:B08006 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos.61874150 O the O Sichuan B-ORG Key I-ORG Project I-ORG for I-ORG Applied I-ORG Fundamental I-ORG Research I-ORG 20YYJC4341 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Chongqing I-ORG cstc2019jcyj-msxmX0824 O and O Chongqing B-ORG Postdoctoral I-ORG Science I-ORG Special I-ORG Foundation I-ORG No. O Xm2017051 B-AWARD This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFA0202604 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51579198 O the O Shenzhen O Science O and O Technology O Innovation O Free O Exploration O Project O JCYJ20170818140127741 O the O Startup O Foundation O of O Shenzhen O Technology O University O 201701 O and O Wuhan B-ORG Morning I-ORG Light I-ORG Plan I-ORG of I-ORG Youth I-ORG Science I-ORG and I-ORG Technology I-ORG 2017050304010316 O This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O number O 2022YFA1104704 B-AWARD the O major O projects O of O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 92059204 B-AWARD the O major O projects O of O Technological B-ORG Innovation I-ORG and I-ORG Application I-ORG Development I-ORG Foundation I-ORG of I-ORG Chongqing I-ORG grant O number O CSTB2022TIAD-STX0012 B-AWARD This O research O was O funded O by O grants O from O the B-ORG Special I-ORG Fund I-ORG of I-ORG Peking I-ORG University I-ORG Health I-ORG Science I-ORG Center I-ORG BMU2021RCZX013 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81974309 B-AWARD and I-AWARD 82172251 O and O the B-ORG National I-ORG Major I-ORG Scientific I-ORG and I-ORG Technological I-ORG Special I-ORG Project I-ORG during I-ORG the I-ORG Thirteenth I-ORG Five-Year I-ORG Plan I-ORG Period I-ORG 2017ZX10201201003 B-AWARD This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31870114 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2018YFD1100503 B-AWARD and O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Urban I-ORG Water I-ORG Resource I-ORG and I-ORG Environment I-ORG Harbin O Institute O of O Technology O No. O 2019DX02 B-AWARD Wellcome B-ORG Centre I-ORG for I-ORG Mitochondrial I-ORG Research I-ORG 203105/Z/16/Z O to O R.H O Medical B-ORG Research I-ORG Council I-ORG UK) O MR/N025431/1 O to O R.H O Wellcome B-ORG Investigator I-ORG 109915/Z/15/Z O to O R.H O Newton B-ORG Fund I-ORG UK/Turkey O MR/N027302/1 O to O R.H O European B-ORG Research I-ORG Council I-ORG 309548 O to O R.H O Wellcome B-ORG Trust I-ORG Pathfinder I-ORG Scheme I-ORG 201064/Z/16/Z O to O R.H O This O work O was O supported O by O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Project I-ORG 2013BAD07B00),http://program.most.gov.cn O and O the O State B-ORG Key I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0300103),http://service.most.gov.cn O and O the B-ORG National I-ORG Agricultural I-ORG Industry I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG CRRS-02),http://cars.wmelon.org O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O theSwedish O Research I-ORG Council(2011-488,2013-3477 O theSwedish O Radiation I-ORG Safety I-ORG Authority(2012-2021,2013-2982 O theSwedish O Federal I-ORG Governmentunder O the O LUA/ALF O agreement O ALFGBG-136281,ALFGBG-428961 O and O theHealth O and I-ORG Medical I-ORG Care I-ORG Committeeof O the O Region O Västra O Götaland O VGFOUREG-81341,VGFOUREG-483951 O The O study O was O sponsored O by O Health B-ORG Data I-ORG Research I-ORG UK I-ORG www.hdruk.ac.uk O grant O reference O number O MR/S003800/1 B-AWARD MF) O which O is O a O joint O investment O led O by O the O Medical O Research O Council O together O with O the O National O Institute O for O Health O Research O England O the O Chief O Scientist O Office O Scotland O Health O and O Care O Research O Wales O Health O and O Social O Care O Research O and O Development O Division O Public O Health O Agency O Northern O Ireland O the O Engineering O and O Physical O Sciences O Research O Council O the O Economic O and O Social O Research O Council O the O British O Heart O Foundation O and O Wellcome O There O was O additional O funding O from O the O Carnegie B-ORG Trust I-ORG for O the O Universities O of O Scotland O grant O reference O VAC007974 B-AWARD EES O and O an O MRC O Mental B-ORG Health I-ORG Data I-ORG Pathfinder I-ORG grant O grant O reference O MC_PC_17217 B-AWARD MF, O JPP O DK, O SC O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no: O 81871756 B-AWARD High-Level B-ORG Medical I-ORG Talents I-ORG Training I-ORG Project I-ORG of I-ORG Changzhou I-ORG grant O no: O 2016CZLJ004 B-AWARD the B-ORG Municipal I-ORG Social I-ORG Development I-ORG Project I-ORG of I-ORG the I-ORG Changzhou I-ORG City I-ORG Jiangsu I-ORG Province I-ORG China I-ORG grant O no: O CJ20180073 B-AWARD and O Youth O Project I-ORG of I-ORG Changzhou I-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG grant O no: O QN201718 B-AWARD This O work O was O supported O by O the O grants O from O the O Drug B-ORG Innovation I-ORG Major I-ORG Project I-ORG 2018ZX09711001-003-007 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81630099 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG of I-ORG China I-ORG No. O 19KJA310004 B-AWARD This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51603066 B-AWARD NSAF B-ORG U1730142 O U1930203 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG No. O 2019JJ40071 B-AWARD the O Science O Research O Project O of O Hunan O Provincial O Department O of O Education O No. O 18A257 O and O the O Student O Innovation O and O Entrepreneurship O Training O Program O of O China O No. O 201911535005 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 21778011 B-AWARD the O Great O Wall O Scholars O Program O of O Beijing O Municipal O Education O Commission O No. O CIT&TCD20180308 O Education O Commission O Science O and O Technology O Project O of O Beijing O Municipality O No. O PXM2015_014204_500175 O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 7184192 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2017M620567 B-AWARD Beijing B-ORG Postdoctoral I-ORG Research I-ORG Foundation I-ORG No. O 2018-ZZ-022 B-AWARD and O Chaoyang O District O Postdoctoral O Research O Foundation O No. O 2018ZZ-01-25 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81560343 B-AWARD Science B-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG of I-ORG Gansu I-ORG 18YF1FA108 O Lanzhou B-ORG University I-ORG Second I-ORG Hospital I-ORG Doctoral I-ORG Research I-ORG Fund I-ORG Project I-ORG Ynbskyjj2015-1-6 O This O work O was O supported O by O the O First B-ORG Affiliated I-ORG Hospital I-ORG of I-ORG Guangzhou I-ORG Medical I-ORG University I-ORG 2010A060801016 B-AWARD to O Ri-jin O Song O the O Talent B-ORG Health I-ORG Youth I-ORG Project I-ORG of I-ORG Suzhou I-ORG City I-ORG GGRC052 B-AWARD and O the O Youth O Project O of O Suzhou O City O kjxw2018073 O to O Chen O Xu O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O developed O within O the O ExpoLIS O project O funded O by O FEDER B-ORG through O Programa O Operacional O Regional O de O Lisboa O LISBOA-01-0145-FEDER-032088 O and O by O national B-ORG funds I-ORG OE O through O Fundação O para O a O Ciência O e O a O Tecnologia O FCT O I.P O Portugal O PTDC/EAM-AMB/32088/2017 O Part O of O this O work O was O also O supported O by O FCT O under O ISTAR O projects O UIDB/04466/2020 B-AWARD and O UIDP/04466/2020 B-AWARD and O C2TN B-ORG projects O UIDB/04349/2020 B-AWARD and O UIDP/04349/2020 B-AWARD We O acknowledge O support O from O the O Swiss B-ORG National I-ORG Centre I-ORG of I-ORG Competence I-ORG in I-ORG Research I-ORG LIVES—Overcoming I-ORG vulnerability O life O course O perspectives O which O is O funded O by O the O Swiss B-ORG National I-ORG Science I-ORG Foundation I-ORG grant O number O 51NF40-185901 B-AWARD Moreover O A.I O acknowledges O support O from O the O Swiss O National O Science O Foundation O grant O number O 10001C_189407 B-AWARD É.R.G O acknowledges O support O from O LARSyS—Portuguese B-ORG national I-ORG funding O agency O for O science O research O and O technology O FCT O pluriannual O funding O 2020–2023 O Reference O ITI-LX B-AWARD UIDP/50009/2020—IST-ID O Filipe O Manuel O Clemente O and O this O work O are O funded O by O the O Fundação B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG Tecnologia/Ministério I-ORG da I-ORG Ciência I-ORG Tecnologia I-ORG e I-ORG Ensino I-ORG Superior I-ORG through O national O funds O and O when O applicable O co-funded O by O EU O funds O under O the O project O UIDB/50008/2020 B-AWARD This O work O was O supported O by O the O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG Grant O no. O 17140902300 B-AWARD Shanghai B-ORG Key I-ORG Laboratory I-ORG of I-ORG Kidney I-ORG and I-ORG Blood I-ORG Purification I-ORG Grant O no. O 14DZ2260200 B-AWARD Shanghai B-ORG Shenkang I-ORG Hospital I-ORG Development I-ORG Center I-ORG New I-ORG Frontier I-ORG Technology I-ORG Joint I-ORG Project I-ORG Grant O no. O SHDC12018127 B-AWARD and O the O Xiamen B-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG in I-ORG 2018 I-ORG Grant O no. O 3502Z20184009 B-AWARD The O funder O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O in O writing O the O manuscript O of O the O manuscript O and O in O the O decision O to O submit O the O article O for O publication O This O work O was O supported O by O a O Key B-ORG Project I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O Grant O ID: O 8177060452 B-AWARD This O work O was O supported O by O Key B-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Sichuan I-ORG Province O Grant O ID: O 2017SZ0067 B-AWARD and O 1.3.5 B-ORG project I-ORG for I-ORG disciplines I-ORG of I-ORG excellence I-ORG West I-ORG China I-ORG Hospital I-ORG Sichuan I-ORG university O Grant O ID: O ZY2016104 B-AWARD The O study O sponsor O had O no O role O in O the O design O and O conduct O of O the O study O collection O management O analysis O and O interpretation O of O the O data O preparation O review O or O approval O of O the O article O and O decision O to O submit O the O article O for O publication O This O work O was O supported O by O Shandong B-ORG Agricultural I-ORG Good I-ORG Cultivar I-ORG Project I-ORG Grant O No. O 2016LZGC034 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31501742 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG Grant O No. O ZR2019MC071 B-AWARD and O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG SAAS I-ORG CXGC2016A03 O and O CXGC2018F03 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O Rashtriya B-ORG Uchchattar I-ORG Shiksha I-ORG Abhiyan I-ORG RUSA I-ORG 2.0 I-ORG India-Bharathiar I-ORG Cancer I-ORG Theranostics I-ORG Research I-ORG Center I-ORG BCTRC O Grant O No. O BU/RUSA2.0/BCTRC/2020/BCTRC-CT01 B-AWARD This O research O also O was O supported O by O ‘The O Regional O Innovation O Strategy O RIS)’ O through O the O National B-ORG Research I-ORG Foundation I-ORG NRF I-ORG of I-ORG Korea O funded O by O the O Ministry O of O Education O MOE O No. O 2021RIS-001 B-AWARD This O research O was O supported O by O the O ‘Bio-Convergence O Technology O Education O Program’ O through O the O Korea B-ORG Institute I-ORG for I-ORG Advancement I-ORG of I-ORG Technology I-ORG KIAT O funded O by O the O Ministry O of O Trade O Industry O and O Energy O MOTIE O No. O P0017805 B-AWARD This O work O was O supported O by O the O Chinese B-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG grant O numbers O 2016-I2M-2-001 B-AWARD 2018-I2M-3-001 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG grant O number O 3332018029 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 81772009 B-AWARD 81772012 B-AWARD the O Scientific B-ORG and I-ORG Technological I-ORG Research I-ORG Project I-ORG of I-ORG Henan I-ORG Province I-ORG grant O number O 182102310162 B-AWARD the O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG grant O number O 7182109 B-AWARD the O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG grant O numbers O GJJSTD20170004 B-AWARD and O QYZDJ-SSW-JSC005 B-AWARD and O the O Youth B-ORG Innovation I-ORG Promotion I-ORG Association I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG grant O number O 2019136 B-AWARD This O work O was O supported O by O the O Skane B-ORG Region I-ORG County I-ORG Council I-ORG 16-10-31 O Lindhaga B-ORG Foundation I-ORG 13-06-06 O Johan B-ORG Olsson I-ORG Foundation I-ORG 16-12-06 O Mohd O Azrul O Naim O was O funded O by O Ministry B-ORG of I-ORG Higher I-ORG Education I-ORG Malaysia I-ORG KPT O BS-830623115465 O for O “Skim O Latihan O Akademik O IPTA O SLAI)” O program O and O Detmer O Sipkema O was O funded O by O European B-ORG Community’s I-ORG Seventh I-ORG Framework I-ORG Program I-ORG projects I-ORG MetaExplore I-ORG grant O agreement O number O 222625 B-AWARD and O BluePharmTrain B-ORG grant O agreement O number O 607786 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O I.P.-G O receives O funding O from O Agencia B-ORG Nacional I-ORG de I-ORG Investigación I-ORG y I-ORG Desarrollo I-ORG ANID O Chile O FONDECYT O de O postdoctorado O No. O 3190491 B-AWARD F.J.P O receives O funding O from O Agencia O Nacional O de O Investigación O y O Desarrollo O ANID O Chile O FONDECYT O iniciación O en O investigación O No. O 11180620 B-AWARD and O FONDECYT O regular O No. O 1190610 B-AWARD D.C O received O funding O from O Fondo B-ORG Nacional I-ORG de I-ORG Desarrollo I-ORG Cientifico I-ORG y I-ORG Tenológico O FONDECYT O Grant/Award O Number O No. O 1181355 B-AWARD The O study O receives O funding O from O ANID—Millennium O Science I-ORG Initiative I-ORG Program/Millennium I-ORG Institute I-ORG for I-ORG Research I-ORG on I-ORG Depression I-ORG and I-ORG Personality-MIDAP I-ORG ICS13_005 B-AWARD This O work O was O supported O partially O by O the O Ningbo B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 2021Z030 O the O Scientific B-ORG Research I-ORG Foundation I-ORG for I-ORG Talent I-ORG Introduction I-ORG of I-ORG Zhejiang I-ORG University I-ORG Ningbo I-ORG Campus I-ORG 20201203Z0180 O the O Ningbo B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2022J159 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2022YFB2804101 O and O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2021C03178 O 2023C03135 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 51675386 B-AWARD U1501241 B-AWARD and O 51775387 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFB1104900 B-AWARD and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG No. O 2018CFA091 B-AWARD This O work O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG for I-ORG Young I-ORG Scientists I-ORG of I-ORG China I-ORG to O Zhang O HF O Grant O No.81300071 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG of I-ORG China I-ORG to O Lin O YQ O Grant O No.2014A030313049 O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG of I-ORG China I-ORG to O Zhang O HF O Grant O No. O 201510010048 B-AWARD and O Wang O JF O Grant O No. O 2014Y2-00118 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG to O Zhang O HF O Grant O No. O 13ykpy30 B-AWARD The O study O was O supported O by O two O projects O under O grant O Number O 2012AA1214002 O and O 2012AA1214003 O the B-ORG Hi-Tech I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O No. O 2012AA1214000 B-AWARD the B-ORG Specialized I-ORG Research I-ORG Fund I-ORG for I-ORG the I-ORG Doctoral I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG grant O No. O 20115303110002 B-AWARD the B-ORG Yunnan I-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG grant O No. O 2011XX2005 B-AWARD the B-ORG Yunnan I-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG Research I-ORG Fund I-ORG grant O No. O 2011Y307 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O No. O 41461038 B-AWARD and O the O National O Natural O Science O Foundation O of O China O grant O No. O 41661087 B-AWARD Ontario B-ORG Ministry I-ORG of I-ORG Agriculture I-ORG Food I-ORG and I-ORG Rural I-ORG Affairs O OMAFRA B-AWARD New I-AWARD Direction I-AWARD Grant I-AWARD ND2018-3410 O Grain B-ORG Farmers I-ORG of I-ORG Ontario O Grant B-AWARD C2019AG02 O Natural B-ORG Sciences I-ORG and I-ORG Engineering I-ORG Research I-ORG Council I-ORG of I-ORG Canada O NSERC B-AWARD Discovery I-AWARD Grant I-AWARD 401267 I-AWARD This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC0910202 O and O 2016YFC1306300 B-AWARD the O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 7172076 O the O Beijing B-ORG Cooperative I-ORG Construction I-ORG Project I-ORG 110651103 O the O Beijing B-ORG Normal I-ORG University I-ORG 11100704 O and O the O Peking O Union B-ORG Medical I-ORG College I-ORG Hospital I-ORG 2016-2.27 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the B-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG support I-ORG planning I-ORG project I-ORG No. O 2015BAD03B03 B-AWARD the B-ORG National I-ORG modern I-ORG agricultural I-ORG technology I-ORG system I-ORG construction I-ORG of I-ORG China I-ORG no. O CARS-42-G04 B-AWARD the B-ORG Province I-ORG Key I-ORG Technologies I-ORG R I-ORG I-ORG D I-ORG Program I-ORG of I-ORG Livestock I-ORG and I-ORG Poultry I-ORG Breeding I-ORG Programs I-ORG of I-ORG Sichuan I-ORG Province I-ORG No. O 2016NYZ0043 B-AWARD the B-ORG Science I-ORG and I-ORG Technology I-ORG support I-ORG planning I-ORG project I-ORG of I-ORG Sichuan I-ORG Province I-ORG No. O 2016NZ0003 B-AWARD The O Burden O of O Disease O Epidemiology O Equity O O Cost-Effectiveness O Programme O BODE3 O which O supported O this O research O is O funded O by O the O Health B-ORG Research I-ORG Council I-ORG of I-ORG New I-ORG Zealand I-ORG www.hrc.govt.nz O 16/443 O Funding O support O was O also O provided O by O the O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG GNT1084347 O and O the O Australian B-ORG Research I-ORG Council I-ORG CE170100005 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O this O manuscript O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21607041 O and O 51803056 O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG China I-ORG 2017C33240 O the B-ORG China I-ORG Scholarship I-ORG Council I-ORG 201708330103 O and O General O Project O of O Zhejiang O Provincial O Department O of O Education O Y201737320 O This O work O was O supported O by O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Taiwan I-ORG 109-2314-B-038-124-MY3 O 110-2314-B-038-128 B-AWARD 110-2314-B-038-107-MY3 B-AWARD and O 111-2811-B-038-014 B-AWARD Wan B-ORG Fang I-ORG Hospital I-ORG 111-wf-f-7 O and O the O Foundation B-ORG for I-ORG the I-ORG Development I-ORG of I-ORG Internal I-ORG Medicine I-ORG in I-ORG Okinawa I-ORG 04-02-001 O This O work O was O supported O by O the O Bill B-ORG and I-ORG Melinda I-ORG Gates I-ORG Foundation I-ORG OPP1169555 O The O RECIPAL O project O was O supported O by O the O French O Agence B-ORG Nationale I-ORG de I-ORG la I-ORG Recherche I-ORG ANR-13-JSV1-0004 O and O the O Fondation B-ORG Simone I-ORG Beer I-ORG under O the O auspices O of O the O Fondation O de O France O 00074147 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Financial O support O came O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG contract O grant O no. O 51674045 B-AWARD Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Support O Project O contract O grant O no. O 2015SZ0007 B-AWARD and O Sichuan B-ORG Support I-ORG Foundation I-ORG for I-ORG Academic I-ORG and I-ORG Technological I-ORG Leader I-ORG contract O grant O no. O 10900-XDPY-1702 B-AWARD This O study O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81702120 O the O Industrial B-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Funding I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG 20160911 O and O the O Clinical B-ORG Medicine I-ORG Research I-ORG and I-ORG Transformation I-ORG Project I-ORG of I-ORG Guangzhou I-ORG City I-ORG 201604020004 O The O synthesis O the O study O of O anticancer O and O antimicrobial O activities O were O carried O out O at O the O Arbuzov O Institute O of O Organic O and O Physical O Chemistry O and O were O supported O by O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Higher I-ORG Education I-ORG of I-ORG the I-ORG Russian I-ORG Federation I-ORG at I-ORG FRC I-ORG Kazan I-ORG Scientific I-ORG Center I-ORG grant O No. O 075-15-2022-1128 B-AWARD Two-dimensional O NMR O experiments O were O funded O by O the O government O assignment O for O the O FRC O Kazan O Scientific O Center O of O RAS O The O study O of O hemolytic O activity O was O funded O by O the O financial O support O for O research O from O the O Ministry B-ORG of I-ORG Agriculture I-ORG of I-ORG the I-ORG Republic I-ORG of I-ORG Kazakhstan I-ORG BR10764960 O L.K O acknowledges O support O by O the O National B-ORG Science I-ORG Foundation I-ORG Graduate I-ORG Research I-ORG Fellowship I-ORG under O Grant O No. O 1449440 B-AWARD for O quantum-chemical O computations O realization O This O study O design O data O collection O analysis O data O interpretation O and O writing O were O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 71532002 B-AWARD the O National B-ORG Social I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 18ZDA086 B-AWARD and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG grant O number O 2019YJS056 B-AWARD The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O these O funding O organizations O The O funding O bodies O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O grants O from O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG No. O 2019J01408 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31500753 B-AWARD and O the O Earmarked B-ORG Fund I-ORG for I-ORG Modern I-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG No.CARS-44-KXJ4 O The O funding O body O provided O financial O support O and O had O no O role O in O the O design O of O the O study O collection O analysis O interpretation O of O data O or O writing O the O manuscript O This O study O was O supported O by O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG 2017-I2M-3-007 O The B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFA0101000 O 2016YFA0101003 O Beijing B-ORG Key I-ORG Laboratory I-ORG of I-ORG New I-ORG Drug I-ORG Development I-ORG and I-ORG Clinical I-ORG Trial I-ORG of I-ORG Stem I-ORG Cell I-ORG Therapy I-ORG BZ0381 O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81570560 O The B-ORG Shanghai I-ORG key I-ORG project I-ORG of I-ORG Integrated I-ORG Traditional I-ORG Chinese I-ORG and I-ORG Western I-ORG Medicine I-ORG ZY O 2018-2020)-FWTX-3001 O Technology B-ORG Supporting I-ORG Project I-ORG of I-ORG the I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG Shanghai I-ORG Municipality I-ORG 16411960300 O Shanghai B-ORG Municipal I-ORG Key I-ORG Clinical I-ORG Specialty I-ORG Infectious O disease O YW20190002 B-AWARD National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG 2018ZX10205504-001-002 O 2014ZX10005001 B-AWARD and O Shanghai B-ORG Municipal I-ORG Hospitals I-ORG project I-ORG Improving I-ORG Clinical I-ORG Skills I-ORG of I-ORG Major I-ORG Diseases I-ORG 16CR1026B O This O work O was O supported O by O the B-ORG Science I-ORG and I-ORG technology I-ORG support I-ORG program I-ORG ID: O 2012BAD14B13 B-AWARD and I-AWARD 2013BAD07B08 I-AWARD ZLG O AND O YXM O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31328020 O GHJ O the B-ORG State I-ORG Key I-ORG Special I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0200107 O 2016YFD0300801 I-AWARD 2016YFD0300900 I-AWARD GHJ O and O the B-ORG Project I-ORG of I-ORG the I-ORG Introduction I-ORG of I-ORG the I-ORG Leading I-ORG Talent I-ORG Team I-ORG in I-ORG Colleges I-ORG and I-ORG Universities I-ORG of I-ORG Anhui I-ORG Province I-ORG of I-ORG China I-ORG gxljtdzd201607 O GHJ O The O project O described O in O this O publication O was O supported O by O the O University O of O Rochester O CTSA O award O number O KL2TR001999 B-AWARD from O the O National B-ORG Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences I-ORG of O the O National O Institutes O of O Health O RFD O The O work O was O also O funded O through O UG1 B-AWARD CA189961 I-AWARD from O the O National B-ORG Cancer I-ORG Institute I-ORG KMM O and O K24AG056589 B-AWARD SGM O from O the O National B-ORG Institute I-ORG on I-ORG Aging O All O statements O in O this O report O including O its O findings O and O conclusions O are O solely O those O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O National O Institutes O of O Health O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31630191 O 31630088 B-AWARD Youth B-ORG Fund I-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG 201740023 O 20154Y0065 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG 17ZR1406200 O and O the O Human B-ORG Phenome I-ORG Institute I-ORG of I-ORG Fudan I-ORG University I-ORG HUPIKF2018101 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O No. O 41871167 B-AWARD 42271299 B-AWARD Fujian B-ORG Provincial I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Issue I-ORG grant O No. O 2019R1007-1 B-AWARD Ningbo B-ORG Commonweal I-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG grant O No. O 2021S081 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG grant O No. O 2022J01511 B-AWARD This O work O was O funded O by O the O Agence B-ORG Nationale I-ORG de I-ORG la I-ORG Recherche I-ORG grant O ANR-14-CE14-0029 B-AWARD and O 15CE15-00028 B-AWARD the O European O Union’s O Horizon O 2020 O research O and O innovation O programme O under O ZIKAlliance O grant O agreement O No. O 734548 O Mahidol B-ORG University I-ORG A39/2561 O and O Thailand B-ORG Research I-ORG Fund I-ORG MRG6280009 O This O work O was O also O publicly O funded O through O the O French O National O Research O Agency O under O the O “Investissements O d’avenir” O programme O with O the O reference O ANR-16-IDEX-0006 O The O authors O would O like O to O acknowledge O the O support O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81601347 B-AWARD 81503156 B-AWARD 81320108027 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2014A030310096 B-AWARD and O Public B-ORG Welfare I-ORG Research I-ORG and I-ORG Capacity I-ORG Building I-ORG Fund I-ORG of I-ORG Guangdong I-ORG No. O 2016A020218006 B-AWARD This O research O was O supported O by O an O Australian B-ORG Research I-ORG Council I-ORG Future I-ORG Fellowship I-ORG FT130100968 B-AWARD to O A.R.E O an O Australian B-ORG Research I-ORG Council I-ORG Linkage I-ORG Project I-ORG LP150100403 B-AWARD to O A.R.E O and O E.M.G.F O and O a O Marie B-ORG Skłodowska-Curie I-ORG Global I-ORG Postdoctoral I-ORG fellowship I-ORG 656010 O MYSTICETI O to O F.G.M O This O study O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Ningxia I-ORG Hui I-ORG Autonomous I-ORG Region I-ORG 2020AAC03079 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31660694 O the B-ORG top I-ORG Discipline I-ORG Construction I-ORG Project I-ORG of I-ORG Pratacultural I-ORG Science I-ORG NXYLXK2017A01 O and O the B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Ningxia I-ORG Hui I-ORG Autonomous I-ORG Region I-ORG 2021BBF02034 O and O 2021BEG02042 B-AWARD This O research O was O funded O by O a O variety O of O sources O We O thank O the O Engineering B-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG EPSRC O Doctoral O Training O Partnership O DTP O via O The O University O of O Manchester O EP/N509565/1 O 1786315 O to O fund O A.M’s O research O as O well O as O the O Agency B-ORG for I-ORG Science I-ORG Technology I-ORG and I-ORG Research I-ORG A*STAR O via O the O A*STAR B-AWARD Research I-AWARD Attachment I-AWARD Programme I-AWARD ARAP O An O EPSRC O National O Productivity O Investment O Fund O NPIF O grant O EP/R512564/1 O 2065445 O to O Lancaster O University O supported O M.D.A O J.G.H O was O supported O by O an O EPSRC O First O Grant O EP/R003823/1 O a O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG BBSRC O Networks O in O Industrial O Biotechnology O and O Bioenergy O NIBB O “FoodWasteNet” O FWN O grant O BB/L0137971/1 B-AWARD Proof O of O Concept O Grant O and O a O Royal O Society O Research O Grant O RG160449 O This O work O was O supported O by O Grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O U1504817 B-AWARD 81802718 B-AWARD 81870591 B-AWARD the O Foundation B-ORG of I-ORG Science I-ORG I-ORG Technology I-ORG Department I-ORG of I-ORG Henan I-ORG Province I-ORG China I-ORG Nos O 182102310335 B-AWARD 162300410233 B-AWARD 162300410036 B-AWARD the O Science B-ORG Foundation I-ORG of I-ORG Kaifeng I-ORG City I-ORG China I-ORG Nos O 1608004 B-AWARD 1703016 B-AWARD the O Science B-ORG Foundation I-ORG of I-ORG Henan I-ORG University I-ORG China I-ORG No. O yqpy20170044 B-AWARD and O the O Open B-ORG Fund I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Tea I-ORG Plant I-ORG Biology I-ORG and I-ORG Utilization I-ORG China I-ORG No. O SKLTOF20160106 B-AWARD This O work O was O supported O by O STI2030-Major B-ORG Projects I-ORG 2021ZD0201003 O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDB32030200 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31830035 O 21921004 B-AWARD Shenzhen B-ORG Key I-ORG Laboratory I-ORG of I-ORG Viral I-ORG Vectors I-ORG for I-ORG Biomedicine I-ORG ZDSYS20200811142401005 O Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG JCYJ20220530154402005 O Research B-ORG Foundation I-ORG Flanders I-ORG 11D4621N O G0I1522N B-AWARD G0B0420N B-AWARD Strategic O Research O Program O Financing O from O the O VUB B-ORG SRP50 O KU B-ORG Leuven I-ORG C16/17/006 O Funding O for O open O access O charge O FWO-FNRS B-ORG EOS I-ORG G0I1522N O The O work O was O supported O by O a O grant O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81560631 B-AWARD the O Distinguished B-ORG Young I-ORG Scholars I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Province I-ORG No. O 20162BCB23022 B-AWARD Key B-ORG research I-ORG and I-ORG development I-ORG program I-ORG of I-ORG Jiangxi I-ORG Province I-ORG No. O 20171BBG70086 B-AWARD and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Province I-ORG No. O 20151BBG70158 B-AWARD This O work O was O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0101002 O Heilongjiang B-ORG Bayi I-ORG Agricultural I-ORG University I-ORG Scientific I-ORG Start-up I-ORG Found I-ORG for I-ORG the I-ORG Returned I-ORG Overseas I-ORG Chinese I-ORG Scholar I-ORG 2031011047 O Heilongjiang B-ORG Bayi I-ORG Agricultural I-ORG University I-ORG Key I-ORG Cultivateing I-ORG Program I-ORG XA2014-01 O Heilongjiang B-ORG Bayi I-ORG Agricultural I-ORG University I-ORG Graduate I-ORG Student I-ORG Innovation I-ORG Fund I-ORG Projects I-ORG YJSCX O 2017-Z01 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O in O part O by O the O Patient-Centered B-ORG Outcomes I-ORG Research I-ORG Institute I-ORG Grant O No. O CDRN-1306-04869 B-AWARD the O National B-ORG Institute I-ORG on I-ORG Minority I-ORG Health I-ORG and I-ORG Health I-ORG Disparities I-ORG Grant O No. O U54-MD007593 B-AWARD the O National B-ORG Center I-ORG for I-ORG Research I-ORG Resources I-ORG Grant O No. O UL1-RR024975 B-AWARD and O the O National B-ORG Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences I-ORG Grant O No. O UL1-TR000445 B-AWARD This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O No. B-AWARD 81172110 O website:http://www.nsfc.gov.cn/publish/portal1 O the O author O who O received O the O funding O LS O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG grant O number O No. B-AWARD 2012AA I-AWARD 02A I-AWARD 504 O website:http://www.863.gov.cn O the O author O who O received O the O funding O LS O and O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG No. O 2014CBA02002 O website:http://www.973.gov.cn O the O author O who O received O the O funding O LS O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O project O was O supported O in O part O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31372448 O the B-ORG Special I-ORG Fund I-ORG for I-ORG Agro-scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG 201303042 O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG S2013020013858 O the B-ORG Promote I-ORG Scientific I-ORG and I-ORG Technological I-ORG Development I-ORG Program I-ORG 2013B040200032 O the O Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG 20140224 O 2013B020202001 O and O the B-ORG Guangdong I-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Prevention I-ORG and I-ORG Control I-ORG for I-ORG Severe I-ORG Clinical I-ORG Animal I-ORG Diseases I-ORG 2013A061401013 O This O study O was O supported O by O the O Science B-ORG and I-ORG Technology I-ORG project I-ORG of I-ORG Chengguan I-ORG District I-ORG Lanzhou I-ORG city I-ORG Gansu I-ORG province I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG Project O number O 2017KJGG0052 B-AWARD the O Cuiying B-ORG Graduate I-ORG Supervisor I-ORG Applicant I-ORG Training I-ORG Program I-ORG of I-ORG Lanzhou I-ORG University I-ORG Second I-ORG Hospital I-ORG 201704 O the O Gansu B-ORG Health I-ORG Industry I-ORG Research I-ORG Project I-ORG GSWSKY2017-10 O the O Cuiying B-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG Program I-ORG of I-ORG Lanzhou I-ORG University I-ORG Second I-ORG Hospital I-ORG Project O number O CY2017-BJ16 B-AWARD Doctoral O supervisor O training O program O and O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO: O 81372732&30800206 B-AWARD There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O National B-ORG Science I-ORG I-ORG Technology I-ORG Pillar I-ORG Program I-ORG during I-ORG the I-ORG Twelfth I-ORG Five-year I-ORG Plan I-ORG Period I-ORG 2013BAD12B04 O the O Military B-ORG Medical I-ORG Health I-ORG project I-ORG in I-ORG China I-ORG 13CXZ024 O the B-ORG National I-ORG Key I-ORG Research I-ORG Program I-ORG during I-ORG the I-ORG Thirteenth I-ORG Five-year I-ORG Plan I-ORG Period I-ORG 2016YFC1201602 O and O the B-ORG Science I-ORG and I-ORG Technology I-ORG Basic I-ORG Work I-ORG Program I-ORG from I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2013FY113600 O The O funders O of O this O study O had O no O role O in O study O design O data O collection O data O analysis O data O interpretation O or O writing O of O the O paper O The O corresponding O authors O had O access O to O the O data O in O the O study O and O had O final O responsibility O for O the O decision O to O submit O for O publication O This O work O was O funded O by O the O National B-ORG College I-ORG Student I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Training I-ORG Program I-ORG No. O 202111488004 B-AWARD the O Research B-ORG Fund I-ORG for I-ORG the I-ORG Quzhou I-ORG University I-ORG No. O BSYJ202015 B-AWARD and O BSYJ202113 B-AWARD and O the O Research B-ORG Fund I-ORG of I-ORG Institute I-ORG of I-ORG Zhejiang I-ORG University-Quzhou I-ORG No. O IZQ2021RCZX030 B-AWARD This O study O was O supported O by O the O National B-ORG Health I-ORG Research I-ORG Institutes I-ORG Taiwan I-ORG NHRI-EX95 O 96, I-AWARD 97, I-AWARD 98, I-AWARD 99-9511PP O NHRI-EX100-10048PI B-AWARD a O grant O from O the O National B-ORG Taiwan I-ORG University I-ORG 97HP0023 O and O a O grant O from O the O Bali B-ORG Psychiatric I-ORG Center I-ORG 99R001 O Funding O agencies O had O no O further O roles O in O the O study O design O in O the O collection O analysis O or O interpretation O of O the O data O in O the O writing O of O the O report O or O in O the O decision O to O submit O the O paper O for O publication O This O work O is O supported O by O grants O from O the O National B-ORG Space I-ORG Biomedical I-ORG Research I-ORG Institute I-ORG NASA O NCC B-AWARD 9-58 O MA02701 B-AWARD and O PF04101 B-AWARD from O the O National B-ORG Aeronautics I-ORG and I-ORG Space I-ORG Administration I-ORG NASA O NNX11AR02G B-AWARD and O NASA O Flight O Analogs O Project O and O the O National O Institutes O of O Health O and O National B-ORG Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences O 1UL1RR029876-01 B-AWARD This O research O was O funded O by O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Higher I-ORG Education I-ORG of I-ORG the I-ORG Russian I-ORG Federation I-ORG project O No. O 0706-2020-0022 B-AWARD by O the O Russian B-ORG Foundation I-ORG for I-ORG Basic I-ORG Research I-ORG RFBR O grant O 18-29-27022 B-AWARD MOST-RFBR O Joint O Research O Project O MOST O grant O No. O 107-2923-E009-002-MY3 O and O RFBR O grant O No. O 18-52-52010 B-AWARD the O Beijing O Natural O Fund O grant O No. O 4182021 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O No. O 61874002 B-AWARD This O research O was O funded O by O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 5217130277 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG Grant O No. O 2021JZ-51 B-AWARD and O the O Foundation B-ORG of I-ORG Education I-ORG Department I-ORG of I-ORG Shaanxi I-ORG Province I-ORG Grant O No. O 20JC007 B-AWARD Research O reported O in O this O publication O was O supported O by O the O National B-ORG Institute I-ORG Of I-ORG General I-ORG Medical I-ORG Sciences I-ORG of I-ORG the I-ORG National I-ORG Institutes I-ORG of I-ORG Health I-ORG under O Award O Number O P20GM104420 B-AWARD This O study O was O also O supported O by O the O Institute O for O Bioinformatics O and O Evolutionary O Studies O Computational O Resources O Core O sponsored O by O the O National O Institutes O of O Health O grant O number O P30GM103324 B-AWARD that O provided O us O computer O resources O This O research O made O use O of O the O resources O of O the O High O Performance O Computing O Center O at O Idaho O National O Laboratory O which O is O supported O by O the O Office B-ORG of I-ORG Nuclear I-ORG Energy I-ORG of I-ORG the I-ORG US I-ORG Department O of O Energy O under O Contract O No. O DE-AC07-05ID14517 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O a O grant O from O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2014A030310025 O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG Grant O No: O 2013B021500010 B-AWARD and O Innovative B-ORG training I-ORG program I-ORG for I-ORG College I-ORG Students I-ORG Grant O No: O 201612121083 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2022B1515020085 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 82104071 B-AWARD Science B-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG of I-ORG Guangzhou I-ORG No. O 202102020703 B-AWARD China O and O Leading B-ORG Entrepreneurship I-ORG Team I-ORG Project I-ORG of I-ORG Zengcheng I-ORG District I-ORG No. O 202001004 B-AWARD MRC B-ORG UK) O MC_PC_12003 O to O C.-C.P O S.C.D O B.Y.W O C.W O to O T.C.H O Returning O Carers’ O Fund O University O of O Oxford O to O N.-Y.C O to O C.-C.P O Cancer O Research O UK O to O W.-C.C O F.B O MRC O UK) O MR/L016591/1to O S.E.K O EPA B-ORG Cephalosporin I-ORG Fund I-ORG CF O 315 I-AWARD to O S.E.K O BBSRC B-ORG BB/K019805/1 O to O J.M.M O Funding O for O open O access O charge O MRC O funding O This O research O was O supported O by O the O Graduate O Research B-ORG and I-ORG Innovation I-ORG Foundation I-ORG of I-ORG Chongqing O China O CYB18032 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51904043 O 51774059 B-AWARD 51764010 B-AWARD 51874109 O Guizhou B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG China I-ORG [2019]2861 O and O Guizhou B-ORG Province I-ORG Excellent I-ORG Youth I-ORG Training I-ORG Plan I-ORG [2019]5674 O This O work O was O supported O by O grants O from O the B-ORG National I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 O Program O Grant O No. O 2014CB964901 B-AWARD the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2016YFC0901700 B-AWARD and O the B-ORG National I-ORG High-tech I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 863 O Program O Grant O No. O 2015AA020100 B-AWARD awarded O to O H.X O Lei O This O work O was O also O supported O by O grants O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81571136 B-AWARD and O the O Beijing B-ORG Municipal I-ORG Science I-ORG I-ORG Technology I-ORG Commission I-ORG Grant O No. O Z171100001017144 B-AWARD awarded O to O L. O Duan O The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O research O was O supported O by O a O strategic O award O from O the O Wellcome O Trust O to O the O University B-ORG of I-ORG Cambridge I-ORG and I-ORG University I-ORG College I-ORG London I-ORG 095844/Z/11/Z O and O a O Clinical B-ORG Fellowship I-ORG from I-ORG the I-ORG Wellcome I-ORG Trust I-ORG awarded I-ORG to I-ORG Prof I-ORG Chamberlain I-ORG reference O 110049/Z/15/Z B-AWARD I-AWARD A). O All O research O at O the O Department O of O Psychiatry O in O the O University O of O Cambridge O is O supported O by O the O NIHR B-ORG Cambridge I-ORG Biomedical I-ORG Research I-ORG Center I-ORG BRC-1215-20014 O and O NIHR B-ORG Applied I-ORG Research I-ORG Collaboration I-ORG East I-ORG of I-ORG England I-ORG ARC O MHL I-AWARD RNAG I-AWARD 565 O TJF O is O an O NIHR O Senior O Investigator O and O PBJ O and O ETB O are O NIHR O Senior O Investigators O Emeriti O SN O was O funded O by O the O Cundill O Center O for O Child O and O Youth O Depression O This O study O was O organized O by O the O University O of O Cambridge O and O the O Cambridgeshire O and O Peterborough O NHS O Foundation O Trust O CPFT O Other O NHS O sites O were O involved O in O the O study O as O recruitment O centers O The O views O expressed O are O those O of O the O author(s O and O not O necessarily O those O of O the O Wellcome O Trust O NHS O the O NIHR O or O the O Department O of O Health O and O Social O Care O This O work O was O supported O by O the O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG No. O 2018-I2M-1-002 B-AWARD National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC2000300 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81171028 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O National B-ORG Institute I-ORG of I-ORG Environmental I-ORG Health I-ORG Sciences I-ORG R44 O ES024698 I-AWARD and O R44 B-AWARD ES021116 O R01 B-AWARD ES022872 O National B-ORG Institute I-ORG of I-ORG Environmental I-ORG Health I-ORG Sciences I-ORG Superfund I-ORG Basic I-ORG Research I-ORG Program I-ORG P42 O ES027707 O Center B-ORG for I-ORG Environmental I-ORG Health I-ORG Sciences I-ORG P30 O ES002109 O J.G O was O supported O by O the O Siebel O Scholars O Program O A.X O was O supported O by O the O Singapore-MIT O Alliance O for O Research O O Technology O BioSystems O and O Micromechanics O IRG O Funding O for O open O access O charge O National O Institute O of O Environmental O Health O Sciences O Superfund O Basic O Research O Program O P42 O ES027707 O This O investigation O was O financed O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 51609075 B-AWARD and O 51778209 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC15087040 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2018B02314 O and O the O Open O Research O Fund O of O Guangxi O Key O Laboratory O of O Water O Engineering O Materials O and O Structures O Guangxi B-ORG institute I-ORG of I-ORG water I-ORG resources I-ORG research I-ORG NO.GXHRI-WEMS-2019-05 O The O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 91547209 B-AWARD and O No. O 51725905 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFA0601503 B-AWARD the O National O Natural O Science O Foundation O of O China O No. O 41571037 B-AWARD and O No. O 51879276 B-AWARD and O the O Research O Fund O of O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Simulation I-ORG and I-ORG Regulation I-ORG of I-ORG Water I-ORG Cycle I-ORG in I-ORG River I-ORG Basins O No. O SKL2018ZY03 B-AWARD This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG nos O 31300792 B-AWARD and I-AWARD 31670967 O We O wish O to O acknowledge O the O financial O support O from O grants O for O Scientific B-ORG Research I-ORG of I-ORG BSKY I-ORG 2015xkj009 O from O Anhui O Medical O University O and O grants O for O Scientific O Research O Foundation O of O the O Institute B-ORG for I-ORG Translational I-ORG Medicine I-ORG of I-ORG Anhui I-ORG Province I-ORG 2017zhyx19 O This O work O was O supported O by O National B-ORG Institutes I-ORG of I-ORG Health O USA O grant O R01CA160688 B-AWARD and O Susan B-ORG G. I-ORG Komen I-ORG Foundation O grant O CCR17481211 B-AWARD to O K.T O and O National B-ORG Cancer I-ORG Institute O USA O cancer O center O support O grant O P30-CA016056 B-AWARD to O Roswell O Park O Comprehensive O Cancer O Center O RPCCC O This O work O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 11674161 B-AWARD 11174122 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grant O No. O BK20181250 B-AWARD and O undergraduate O teaching O reform O project O from O Nanjing B-ORG University I-ORG under O grant O No. O X20191028402 B-AWARD This O research O was O funded O by O Shanxi B-ORG Province I-ORG Science I-ORG Foundation I-ORG for I-ORG Youths I-ORG No. O 20210302124333 B-AWARD and O 201901D211453 O Shanxi B-ORG Province I-ORG Social I-ORG and I-ORG Economic I-ORG Statistics I-ORG Research I-ORG Foundation I-ORG KYZH O 2022]003 O the O Fund B-ORG for I-ORG Shanxi I-ORG “1331” I-ORG Project O and O the O Research B-ORG Foundation I-ORG of I-ORG the I-ORG Chinese I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Coordination I-ORG Chemistry I-ORG SKLCC2204 O This O study O was O supported O by O funding O from O the O USDA B-ORG 58-1265-0-040 O and O Multi-state B-ORG Research I-ORG Project I-ORG W2171 O to O XT, O and O from O the O Basic O Science O Research O Program O through O the O National B-ORG Research I-ORG Foundation I-ORG NRF I-ORG of I-ORG Korea O the O Ministry O of O Education O NRF-2015R1D1A3A01019948 O to O JK. O LG O Life O Sciences O provided O support O in O the O form O of O salaries O for O authors O JP O but O did O not O have O any O additional O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O specific O roles O of O this O author O are O articulated O in O the O ‘author O contributions’ O section O This O research O was O funded O by O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq O grant O 405691/2021-1 B-AWARD and O São B-ORG Paulo I-ORG State I-ORG Research I-ORG Foundation I-ORG FAPESP O grants O 2021/04464-8 B-AWARD 2018/26655-7 B-AWARD 2017/50333-7 B-AWARD 2018/25128-3 B-AWARD 2019/24028-8 B-AWARD and O 2018/03918-2 B-AWARD The O in O silico O molecular O modelling O studies O were O done O through O funding O provided O by O the O BBSRC O International O Partnership O Fund O awarded O to O the O University B-ORG of I-ORG Southampton I-ORG grant O BB/X512035/1 B-AWARD entitled O 22ROMITIGATIONFUNDSouthampton O This O research O was O funded O by O FAPESP B-ORG Fundação O de O Amparo O a O Pesquisa O do O Estado O de O São O Paulo O grant O number O 2017/10940-1 B-AWARD and O by O CAPES B-ORG Coordenação O de O Aperfeiçoamento O de O Pessoal O de O Nível O Superior O financial O code O 001 O to O C.D O by O FAPESP O grant O number O 2018/12871-0 B-AWARD to O E.R.C O and O L.S.R O and O by O NSERC B-ORG Natural O Sciences O and O Engineering O Research O Council O of O Canada O grant O number O 2018-06489 B-AWARD to O A.P O This O work O is O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2022YFF1100700 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32272447 O 32102113 B-AWARD and O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Science I-ORG CAAS-ASTIP-2021 O OCRI O This O work O was O supported O by O grants O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Numbers O 30971195 B-AWARD and I-AWARD 81170069 O the B-ORG Education I-ORG Department I-ORG Hebei I-ORG Province I-ORG Number O ZD2014043 B-AWARD and I-AWARD ZD2014005 O and O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG Numbers O C2011206031 B-AWARD and I-AWARD C2009001053 O ESJ O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O numbers O 91430217 B-AWARD URL O http://www.nsfc.gov.cn O National O Natural O Science O Foundation O of O China O Jin O Wang O The O National B-ORG Key I-ORG Research I-ORG I-ORG Development I-ORG Plan I-ORG MOST I-ORG China O grant O number O 2016YFA0203200 B-AWARD URL O http://www.most.gov.cn/eng/programmes1/200610/t20061009_36224.htm O Ministry O of O Science O and O Technology O of O the O People´s O Republic O of O China O Jin O Wang O and O The O National B-ORG Science I-ORG Foundation O grant O number O PHY-76066 B-AWARD URL O https://www.nsf.gov O National O Science O Foundation O of O American O Jin O Wang O This O work O was O supported O by O the B-ORG National I-ORG 863 I-ORG High I-ORG Tech I-ORG Foundation I-ORG 2014AA020608 O the B-ORG National I-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2013CB911303 O and O 2011CB910703 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31470810 O the B-ORG Science I-ORG I-ORG Technology I-ORG Department I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2017JY0232 O the B-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG Sichuan I-ORG Province I-ORG 17ZD045 O and O Chengdu B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG 2017-GH02-00062-HZ O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O no. O 31870981 B-AWARD Grant B-ORG for I-ORG Key I-ORG Disciplinary I-ORG Project I-ORG of I-ORG Clinical I-ORG Medicine I-ORG under I-ORG the I-ORG Guangdong I-ORG High-level I-ORG University I-ORG Development I-ORG Program I-ORG Grant O no. O 002-18119101 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG Grant O no. O 2017A030313718 B-AWARD This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21872152 O and O 21603240 B-AWARD the O Important B-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG Specific I-ORG Project I-ORG of I-ORG China I-ORG 2017ZX05013-003 O and O 2016ZX05025-003-009 B-AWARD and O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG CAS I-ORG XDB22030102 O This O research O was O supported O by O the O 111 B-ORG Project I-ORG Grant O number O B16031 B-AWARD to O SR),http://www.moe.gov.cn/srcsite/A16/kjs_gjhz/201511/t20151130_221899.html O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Number O 71703084 B-AWARD to O YB),https://isisn.nsfc.gov.cn/egrantweb O Fundamental O Research O Funds O for O the O Central O Universities O Grant O Number O 2016CSY029),http://newyjs.snnu.edu.cn/info/1044/5552.htm O and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O Number O 2017CSY054 B-AWARD to O YS),http://newyjs.snnu.edu.cn/info/1044/5552.htm O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O Scientific B-ORG Research I-ORG and I-ORG Technology I-ORG Development I-ORG Program I-ORG of I-ORG Guangxi I-ORG Grant O No. O AB16380105 B-AWARD Science B-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG Guangxi I-ORG Grant O No. O AA17204088 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG Guangxi I-ORG Academy I-ORG of I-ORG Sciences I-ORG Grant O No. O 2017YJJ23001 B-AWARD the O Team B-ORG Research I-ORG Funds I-ORG for I-ORG Institute I-ORG of I-ORG Marine I-ORG Drugs I-ORG Guangxi I-ORG University I-ORG of I-ORG Chinese I-ORG Medicine I-ORG Grant O No. O 2018ZD005-A10 B-AWARD 2018ZD005-A20 B-AWARD and O the O National B-ORG Modern I-ORG Agricultural I-ORG Industry I-ORG Technology I-ORG System I-ORG Guangxi I-ORG Innovation I-ORG Team I-ORG Grant O No. O nycytxgxcxtd-14-06 B-AWARD This O work O was O supported O by O a O Volkswagen B-ORG Foundation I-ORG grant O to O A.N.T O and O N.A O and O in O the O EU B-ORG H2020 I-ORG MSCA I-ORG ITN I-ORG projects O “Serotonin O and O Beyond” O N O 953327 B-AWARD to O M.B O and O N.A O and O in O part O by O the O Saint B-ORG Petersburg I-ORG State I-ORG University I-ORG intramural O grant O 93024558 B-AWARD to O A.N.T O the O Russian B-ORG Science I-ORG Foundation I-ORG grant O 20-14-00242 B-AWARD to O S.A.S O and O the O Agreement O with O the O Ministry O of O Science O and O Higher O Education O of O the O Russian O Federation O No. O 075-15-2021-1075 O of O 28 O September O 2021 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81771306 O 81072459 I-AWARD 81830083 O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG 201409002900 O 14140904200 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC1200400 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG foundation I-ORG of I-ORG China I-ORG No. O 31700367 B-AWARD the O HAUST B-ORG Discipline I-ORG Improvement I-ORG and I-ORG Promotion I-ORG Plan I-ORG A I-ORG No. O 13660001 B-AWARD 13660002 O and O the O Young B-ORG Teacher I-ORG Training I-ORG Program I-ORG by I-ORG Education I-ORG Department I-ORG of I-ORG Henan I-ORG Province I-ORG No. O 2016GGJS-062 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by: O FAPESP B-ORG 2010/07362-7 B-AWARD LSM I-AWARD 2015/23695-0 I-AWARD LSM I-AWARD 2010/52324-6 I-AWARD ACM I-AWARD 2011/50242-5 I-AWARD ACM I-AWARD 2013/50484-4 I-AWARD ACM O CNPq B-ORG 142270/2010-5 B-AWARD LSM I-AWARD 165066/2014-8 I-AWARD LSM I-AWARD 474672/2007-7 I-AWARD ACM I-AWARD 563106/2010-7 I-AWARD ACM I-AWARD 562143/2010-6 I-AWARD ACM I-AWARD 477156/2011-8 I-AWARD ACM I-AWARD 305805/2013-4 I-AWARD ACM I-AWARD 445444/2014-2 I-AWARD ACM O CAPES/PDSE B-ORG 16499/12-3 B-AWARD LSM O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the O Italian B-ORG Ministry I-ORG of I-ORG Education I-ORG University I-ORG and I-ORG Research I-ORG MIUR O Grants O “PRIN” O grant O no. O 2017BF3PXZ B-AWARD and O the O Engineering B-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG grant O no. O EP/J021180/1 B-AWARD CB O was O recipient O of O a O junior O post-doctoral O research O fellowship O granted O by O University B-ORG of I-ORG Padova I-ORG grant O no. O CPDR150704 B-AWARD This O work O was O funded O by O the O Chongqing B-ORG Yuzhong I-ORG Nature I-ORG Science I-ORG Foundation I-ORG Grant O Number O 20190146 B-AWARD the O Scientific B-ORG Research I-ORG and I-ORG Innovation I-ORG Experiment I-ORG Program I-ORG for I-ORG College I-ORG Students I-ORG of I-ORG Chongqing I-ORG Medical I-ORG University I-ORG Grant O Number O SRIEP202120 B-AWARD and O Chongqing B-ORG Science I-ORG and I-ORG Health I-ORG Joint I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG Technology I-ORG Innovation I-ORG and I-ORG Application I-ORG Development I-ORG Project I-ORG Grant O Number O 2020ZY023699 B-AWARD of O China O The O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41977378 O Major B-ORG Research I-ORG Plan I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grand O No. O 41991323 B-AWARD Research O on O the O Global O Change O of O National O Major O Scientific O Research O Project O of O China O 2015CB953804 O and O Jiangsu B-ORG Provincial I-ORG Basic I-ORG Research I-ORG Program I-ORG Natural I-ORG Science I-ORG Foundation I-ORG General I-ORG Project I-ORG of I-ORG China I-ORG BK20171340 O had O play O an O important O role O in O our O study O design O data O collection O and O analysis O decision O to O publish O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Project I-ORG of I-ORG China I-ORG 81771546 O Clinical B-ORG medical I-ORG technology I-ORG innovation I-ORG guidance I-ORG project I-ORG of I-ORG Hunan I-ORG Provincial I-ORG Science I-ORG I-ORG Technology I-ORG Department I-ORG 2018SK52508 O and I-AWARD 2020SK53404 O Research B-ORG Project I-ORG of I-ORG Hunan I-ORG Provincial I-ORG Health I-ORG Commission I-ORG 2021050120344 O Construction B-ORG project I-ORG of I-ORG graduate I-ORG teaching I-ORG case I-ORG bank I-ORG of I-ORG Central I-ORG South I-ORG University(2021ALK47 O Research B-ORG on I-ORG degree I-ORG and I-ORG postgraduate I-ORG education I-ORG and I-ORG teaching I-ORG reform I-ORG of I-ORG Central I-ORG South I-ORG University(2021JGB057).The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O the O Spanish B-ORG Ministerio I-ORG de I-ORG Ciencia I-ORG e I-ORG Innovación I-ORG project O PCI2020-112091 O the O General B-ORG Secretariat I-ORG for I-ORG Research I-ORG and I-ORG Technology I-ORG of I-ORG Greece I-ORG project O VALUEFARM I-AWARD PRIMA2019-11 O and O PRIMA B-ORG foundation I-ORG under O the O project O VALUEFARM B-AWARD PRIMA/0009/2019 I-AWARD Funded O by O He O Zhou O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO.41606178 O Liaoning B-ORG Doctor I-ORG Scientific I-ORG Research I-ORG Foundation I-ORG Project I-ORG NO.201501185 O Ya-Juan O Li, O Liaoning B-ORG Department I-ORG of I-ORG Education I-ORG Key I-ORG Laboratory I-ORG of I-ORG Basic I-ORG Research I-ORG Project I-ORG No. O LZ2015010 B-AWARD Shahid O Mahboob O International B-ORG Scientific I-ORG Partnership I-ORG Program I-ORG ISPP I-ORG at I-ORG King I-ORG Saud I-ORG University I-ORG for O funding O this O research O work O through O ISPP O No. O 0050 B-AWARD This O work O was O supported O by O Nature B-ORG Science I-ORG Foundation I-ORG from I-ORG the I-ORG Sci-Tech I-ORG Department I-ORG of I-ORG Hainan I-ORG Province I-ORG No. O 2010310162 B-AWARD Shenzhen B-ORG strategic I-ORG emerging I-ORG industry I-ORG development I-ORG special I-ORG fund I-ORG project I-ORG No. O JCYJ20120613103507514 B-AWARD and O Shenzhen B-ORG science I-ORG and I-ORG technology I-ORG innovation I-ORG fund I-ORG project I-ORG No. O JCYJ20160428174605066 B-AWARD This O work O was O supported O by O grants O from O the B-ORG Shaanxi I-ORG Province I-ORG Natural I-ORG Science I-ORG Basic I-ORG Research I-ORG Program I-ORG Grant O No. O 2019JQ-538 B-AWARD the B-ORG Opening I-ORG Foundation I-ORG of I-ORG Key I-ORG Laboratory I-ORG of I-ORG Resource I-ORG Biology I-ORG and I-ORG Biotechnology I-ORG in I-ORG Western I-ORG China I-ORG Northwest I-ORG University I-ORG Ministry I-ORG of I-ORG Education I-ORG No. O ZSK2018002 B-AWARD and O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG Grant O No. O 18JK0796 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61704027 O the O Research B-ORG Fund I-ORG of I-ORG Guangdong–Hong I-ORG Kong–Macao I-ORG Joint I-ORG Laboratory I-ORG for I-ORG Intelligent I-ORG Micro-Nano I-ORG Optoelectronic I-ORG Technology I-ORG No. O 2020B1212030010 B-AWARD the B-ORG Foshan I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG No. O 2020001004898 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2021M700717 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Education I-ORG Department I-ORG of I-ORG Liaoning I-ORG Province I-ORG No. O LJKMZ20220348 B-AWARD This O work O was O supported O by O the O National O Clinical O Research O Center O for O Infectious O Diseases O Funds O for O the O the B-ORG construction I-ORG of I-ORG key I-ORG medical I-ORG disciplines I-ORG in I-ORG Shenzhen I-ORG and I-ORG the I-ORG Sanming I-ORG Project I-ORG of I-ORG Medicine I-ORG in I-ORG Shenzhen I-ORG SZSM201612014 O Chongqing B-ORG Health I-ORG Commission I-ORG COVID-19 I-ORG Project I-ORG 2020NCPZX01 O PLA B-ORG Youth I-ORG Talent I-ORG Project I-ORG 17QNP010 O TMMU O COVID-19 O project O 2020XGBD09 O This O research O was O supported O by O the O National B-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG 2019YFE0106000 O the O Special B-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Cooperation I-ORG of I-ORG Jiangxi I-ORG Province-Science I-ORG and I-ORG Technology I-ORG Cooperation I-ORG of I-ORG Developed I-ORG Countries I-ORG key O Project O 20212BDH80001 O and O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG in I-ORG Jiangxi I-ORG Province I-ORG 20192BBF60045 O This O work O was O financially O supported O by O the O CIBERobn B-ORG Grant O number O CB12/03/30002 B-AWARD Government B-ORG of I-ORG Navarra I-ORG Obekit-PT024 O Microbiota-PI035 B-AWARD and O Nutribiota-0011-1411-2018-000040 B-AWARD projects O and O PRODEP-Mexico B-ORG program I-ORG to I-ORG O.R.L I-ORG UABC-PTC-796 O This O work O was O supported O by O the O Key B-ORG Program I-ORG of I-ORG the I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG of I-ORG China I-ORG ZD2016009 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41671274 O and O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2014BAD11B01-A01 O Natural O Science O Foundation O of O Heilongjiang O Province O of O China O D2018008 O QC2015027 O and O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0300300 O This O work O was O supported O by O the O National B-ORG key I-ORG research I-ORG and I-ORG development I-ORG program I-ORG Beijing O China O grant O no. O 2016YFD0501206 B-AWARD National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 863 I-ORG Beijing O China O grant O no. O 2013AA102806 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Beijing O China O grant O nos O 31360630 B-AWARD 31460681 I-AWARD and I-AWARD 31372494 O and O the O Jilin B-ORG Province I-ORG Science I-ORG Foundation I-ORG for I-ORG Youths I-ORG Changchun O China O grant O no.20160520063JH O Open O access O funding O provided O by O University O of O Graz O This O research O was O supported O by O the O project O FRA-2014 B-AWARD Finanziamenti O di O Ateneo O per O progetti O di O Ricerca O scientifica O by O the O University B-ORG of I-ORG Trieste I-ORG and O by O the O Austrian B-ORG Science I-ORG Fund I-ORG FWF O project I-AWARD P24114-B16 O assigned O to O LM. O The O activity O of O EB O was O partially O funded O by O the O Italian B-ORG Government I-ORG Commission I-ORG with O “Fondo O Trieste.” O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 11604154 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O BK20181315 O the B-ORG Agricultural I-ORG Machinery I-ORG Three I-ORG New I-ORG Project I-ORG No. O SZ120170036 O the B-ORG Asia I-ORG hub I-ORG on I-ORG WEF I-ORG and I-ORG Agriculture I-ORG and I-ORG the I-ORG NAU-MSU I-ORG Joint I-ORG Project I-ORG No. O 2017-H-11 O and O the B-ORG Key I-ORG Research I-ORG Plan I-ORG of I-ORG Yangzhou I-ORG No. O YZ2018038 O This O study O was O financed O in O part O by O the O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG – O Brasil O CAPES O – O Finance O Code O 001 B-AWARD The O authors O acknowledge O PDSE-CAPES B-ORG grant O 88881.190212/2018-01 B-AWARD to O N.S.S O FAPESP B-ORG grant O 2016/06434-0 B-AWARD to O P.J.B O and O CNPq B-ORG grants O 157687/2019-8 B-AWARD to O N.S.S O 436335/2018-2 B-AWARD to O M.W O and O 302781/2016-1 B-AWARD to O M.S O This O work O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O 62205364 O in O part O by O the O China B-ORG Post-doctoral I-ORG Science I-ORG Foundation I-ORG under O Grant O 2022M713291 O in O part O by O the O Shenzhen B-ORG Research I-ORG Foundation I-ORG JSGG20220831103402004 O and O in O part O by O the O Shenzhen O Research O Foundation O JSGG20201103091401005 O This O research O was O supported O in O part O by O programs B-ORG of I-ORG the I-ORG Shandong I-ORG Major I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 2021ZDSYS22 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U21A20297 O Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG ZR2021QH144 O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG for I-ORG Significant I-ORG New I-ORG Drugs I-ORG Development I-ORG 2018ZX09735004 O This O study O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no.81500431 O no.81770561 O and O no.81970499 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG no. O BK20151039 B-AWARD Six B-ORG Talent I-ORG Peaks I-ORG Project I-ORG in I-ORG Jiangsu I-ORG Province I-ORG no.2018-WSW-003 O and O Jiangsu O Province O Leading O Talents O and O Innovation O Team O CXTDA2017033 O The O funding O body O did O not O have O a O role O in O the O design O of O the O study O or O the O collection O analysis O and O interpretation O of O data O This O research O was O funded O by O “1.3.5 O project O for O disciplines O of O excellence O West O China O Hospital O Sichuan B-ORG University” O ZY2016201 O and O “National O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China” O 81701976 O This O work O was O supported O by O an O Early O Career O Research O Fellowship O from O the O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG NHMRC O APP1073250 O ECR O Fellowship O Support O Grant O from O the O University B-ORG of I-ORG Western I-ORG Australia I-ORG to O A.W.D O An O ARC O Future O Fellowship O FT100100291 O supported O K.A.S O This O study O was O supported O by O funding O from O the O Eunice O Kennedy O Shriver O National B-ORG Institute I-ORG of I-ORG Child I-ORG Health I-ORG and I-ORG Human I-ORG Development I-ORG R01HD088516 O to O SH O the O National B-ORG Institute I-ORG on I-ORG Aging I-ORG R03AG070660 O to O SH O the O Bill B-ORG and I-ORG Melinda I-ORG Gates I-ORG Foundation I-ORG INV-023211 O to O GR) O and O New O York O University-Abu O Dhabi O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O and O preparation O of O the O manuscript O This O work O is O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O 62174017 B-AWARD in O part O by O the O National B-ORG Laboratory I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG on I-ORG Analog I-ORG Integrated I-ORG Circuit I-ORG under O Grant O 2021-JCJQ-LB-049-4 B-AWARD and O in O part O by O the O Natural B-ORG Science I-ORG Foundation I-ORG Project I-ORG of I-ORG CQ I-ORG CSTC I-ORG under O Grant O cstc2020jcyjmsxmX0243 B-AWARD This O paper O presents O independent O research O funded O by O the O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG NIHR O under O its O Programme O Grants O for O Applied O Research O scheme O grant O number O RP-PG-1211-20010 B-AWARD and O the O Arthritis B-ORG Research I-ORG UK I-ORG Centre O in O Primary O Care O grant O Grant O Number O 18139 B-AWARD NF O is O supported O through O an O NIHR B-ORG Research I-ORG Professorship I-ORG NIHR-RP-011-015 O The O views O expressed O in O this O publication O are O those O of O the O authors O and O not O necessarily O those O of O the O NHS O the O NIHR O or O the O Department O of O Health O Funders O of O the O study O had O no O role O in O the O design O of O the O study O data-collection O analysis O and O interpretation O of O data O or O in O writing O the O manuscript O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81774171 O the O Beijing B-ORG Municipal I-ORG Education I-ORG Commission I-ORG scientific I-ORG research I-ORG and I-ORG graduate I-ORG training I-ORG to I-ORG build I-ORG projects I-ORG 1000062520025 O the O Tangshan B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Team I-ORG Training I-ORG Program I-ORG 18130219A O the O Chaoyang B-ORG District I-ORG Collaborative I-ORG Innovation I-ORG Project I-ORG CYXC1719 O and O the O Horizontal B-ORG subject I-ORG of I-ORG Zhong I-ORG Fu I-ORG Boai I-ORG Health I-ORG management I-ORG Beijing I-ORG Co I-ORG Ltd I-ORG 218007171720024 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O received O financial O support O from O Dirección B-ORG General I-ORG de I-ORG Universidades I-ORG e I-ORG Investigación I-ORG in O the O form O of O a O grant O awarded O to O JMBC O and O MM-T O PGC2018-093925-B-C31 O and O Consejería O de O Cultura O y O Turismo O de O la O Junta O de O Castilla O y O León O This O study O also O received O financial O support O from O Initiative B-ORG d'Excellence I-ORG in O the O form O of O a O grant O awarded O to O LM-F O ANR-10-IDEX-03-02 O from O the O British B-ORG Academy I-ORG in O the O form O of O a O grant O awarded O to O MM-T O International O Partnership O and O Mobility O Scheme O PM160019 B-AWARD and O from O the O Leakey O Foundation O through O the O personal O support O of O Gordon O Getty O 2013 O and O Dub O Crook O 2014-2016 O 2018 O 2019 O to O MM-T O Further O support O was O provided O in O the O form O of O Fundación O Atapuerca O Post-Doctoral O Research O Grants O awarded O to O MM-P O and O CG. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O financially O supported O by O the O Universidad B-ORG de I-ORG Oviedo I-ORG UNOV-11-MA-02 O Gobierno B-ORG del I-ORG Principado I-ORG de I-ORG Asturias I-ORG SV-PA-13-ECOEMP-62 O and O Fundación O MEDINA O The O polarimeter O IR, O and O NMR O equipment O used O in O this O work O were O acquired O via O grants O for O scientific O and O technological O infrastructures O from O the O Ministerio B-ORG de I-ORG Ciencia I-ORG e I-ORG Innovación I-ORG Grants O No. O PCT-010000-2010-4 B-AWARD NMR O INP-2011-0016-PCT-010000 B-AWARD ACT6 I-AWARD polarimeter O and O IR O The O work O was O funded O by O grants O 175951 B-AWARD from O the O Mexican B-ORG National I-ORG Council I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG CONACyT I-ORG and O IN-210514 B-AWARD from O PAPIIT-UNAM B-ORG PC-A O was O supported O by O PhD O fellowship O No. O 376650 B-AWARD from O CONACyT O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O The B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG 2018YFD0100500 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31830067 O U1302266 O the O 111 B-ORG Project I-ORG B12006 O and O the O Department O of O Agriculture O Projects O of O Modern O Agricultural O Technology O System O CARS-13 O This O study O was O supported O by O grants O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG Foundation I-ORG of I-ORG China I-ORG 2016YFC1306403 O to O Chunjiu O Zhong O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG 20ZR1411300 O to O Changpeng O Wang O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 91332201 O to O Chunjiu O Zhong O and O Zhongshan B-ORG Hospital I-ORG Science I-ORG Foundation I-ORG 2018ZSQN28 O to O Changpeng O Wang O This O work O was O supported O by O the O Shanghai B-ORG Shenkang I-ORG Research I-ORG and I-ORG Development I-ORG Center I-ORG SHDC2020CR3059 O for O H. O Yang O the O National B-ORG Natural I-ORG Science I-ORG Young I-ORG Foundation I-ORG of I-ORG China I-ORG 81802594 O for O W. O Jiang O and O the O Shanghai B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 20ZR1413000 O for O H. O Yang O This O work O was O supported O by O Funds B-ORG of I-ORG Science I-ORG Technology I-ORG Department I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. O 2018C37120 B-AWARD Zhejiang B-ORG Province I-ORG Bureau I-ORG of I-ORG Health I-ORG Nos O 2018ZA012 B-AWARD Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O LQ14H280003 B-AWARD the B-ORG National I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31702144 B-AWARD This O work O was O supported O by O the O National B-ORG Major I-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG of I-ORG China I-ORG Grant O No. O 2018ZX04027001 B-AWARD to O ZG, O Humanities B-ORG and I-ORG social I-ORG sciences I-ORG fund I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG Grant O No. O 20YJCZH150 B-AWARD to O WC, O key B-ORG laboratory I-ORG of I-ORG automotive I-ORG power I-ORG train I-ORG and I-ORG electronics I-ORG Hubei O University O of O Automotive O Technology O No. O ZDK1201703 B-AWARD to O WC, O Hubei B-ORG Provincial I-ORG Education I-ORG Department I-ORG Youth I-ORG Fund I-ORG No. O Q20181801 B-AWARD to O WC, O and O Doctoral B-ORG research I-ORG initiation I-ORG fund I-ORG Hubei O University O of O Automotive O Technology O No. O BK201905 B-AWARD to O WC. O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 81770908 B-AWARD the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC0116000 O and O the B-ORG Shanghai I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG 18411965200 O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2021YFC2104001 O 2022YFC21055001 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2022M711368 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG JUSRP122037 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Jiangsu I-ORG Province I-ORG China I-ORG BK20221081 O This O research O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81372321,81472200,81472441,81672869 O Jiangsu B-ORG Provincial I-ORG Special I-ORG Program I-ORG of I-ORG Medical I-ORG Science I-ORG Funding I-ORG BL2012030 O National B-ORG Science I-ORG Foundation I-ORG for I-ORG Young I-ORG Scholars I-ORG 81302013 O Jiangsu B-ORG Provincial I-ORG Science I-ORG Foundation I-ORG BK20131439,BK20141019 O BK20161596 B-AWARD and O Jiangsu B-ORG Provincial I-ORG Six I-ORG talent I-ORG peak I-ORG of I-ORG Human I-ORG affair I-ORG Hall I-ORG Funding I-ORG 2013-WSW-037,2013-WSN-062 O The O present O study O was O financially O supported O by O the O Hungarian B-ORG Scientific I-ORG Research I-ORG Fund I-ORG OTKA O K113108 O the O National B-ORG Development I-ORG Research I-ORG and I-ORG Innovation I-ORG Fund I-ORG TÉT O 15-1-2016-0044 O the O European B-ORG Union I-ORG and I-ORG the I-ORG European I-ORG Social I-ORG Fund I-ORG EFOP-3.6.1-16-2016-00022 O and O the O Hungarian B-ORG Ministry I-ORG of I-ORG National I-ORG Resources—National I-ORG Talent I-ORG Program I-ORG NTP-EFÖ-P-15-041 O During O manuscript O preparation O Jenny O Q. O Ouyang O was O supported O by O NSF B-ORG OIA-1738594 B-AWARD and O NIH B-ORG P20 B-AWARD GM103650 I-AWARD and O Ádám O Z. O Lendvai O by O the O Romanian B-ORG Ministry I-ORG of I-ORG Education I-ORG PN-III-P4-ID-PCE-2016-0572 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O received O financial O support O from O the O ear-marked O fund O for O Modern B-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG CARS-42-3 O the O National I-ORG Key I-ORG Technology I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2015BAD03B00 O and O the B-ORG Priority I-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Educational I-ORG Institutions I-ORG 2011-137 O This O research O was O funded O by O grant O ZDKJ2019011 B-AWARD and O ZDKJ2021028 B-AWARD from O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Hainan I-ORG Province O grant O NSFC42076127 B-AWARD 42176121 B-AWARD and O 91751108 B-AWARD from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O and O grant O 2018YD01 B-AWARD from O the O Sanya B-ORG city I-ORG The B-ORG Belgian I-ORG Foundation I-ORG Against I-ORG Cancer I-ORG grant O number O C/2014/227 B-AWARD Kom B-ORG op I-ORG tegen I-ORG Kanker I-ORG Stand O up O to O Cancer O the O Flemish O Cancer O Society O grant O number O 00000000116000000206 B-AWARD Royal O College O of O Surgeons/Cancer O Research O UK O C19198/A1533 O The B-ORG Cancer I-ORG Research I-ORG Funds I-ORG of I-ORG Radiumhemmet I-ORG through I-ORG the I-ORG PCM I-ORG program I-ORG at I-ORG KI I-ORG grant O number O 163012 B-AWARD The B-ORG Erling-Persson I-ORG family I-ORG foundation I-ORG grant O number O 4-2689-2016 B-AWARD the O Swedish B-ORG Research I-ORG Council I-ORG grant O number O K2010-70X-20430-04-3 B-AWARD and O the O Swedish B-ORG Cancer I-ORG Foundation I-ORG grant O number O 09-0677 B-AWARD These O funding O bodies O had O no O role O in O the O design O execution O or O interpretation O of O the O data O in O this O study O and O did O not O influence O the O decision O to O submit O results O for O publication O This O work O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG 17ZR1421300 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Xinjiang I-ORG Uygur I-ORG Autonomous I-ORG Region I-ORG of I-ORG China I-ORG 2016D01C084 O the O Shanghai B-ORG Municipal I-ORG Education I-ORG Commission—Gaofeng I-ORG Clinical I-ORG Medicine I-ORG Grant I-ORG Support I-ORG 20161430 O and O the O innovation B-ORG foundation I-ORG of I-ORG translational I-ORG medicine I-ORG of I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG School I-ORG of I-ORG Medicine I-ORG and I-ORG Shanghai I-ORG SJTUSM I-ORG Biobank I-ORG 15ZH4006 O Our O work O was O funded O by O Turku B-ORG University I-ORG Foundation I-ORG Finland O 12353 B-AWARD to O H.M O University O of O Turku O Graduate O School O Finland O to O H.M O V.H O Vilho O Yrjö O ja O Kalle O Väisälän O rahasto O Finland O to O H.M O Finnish B-ORG Cultural I-ORG Foundation I-ORG 00150207 O to O V.H O Academy O of O Finland O 307335 O to O E.T O Ministry O of O Education O Youth O and O Sports O within O the O National O Programme O for O Sustainability O Czech O Republic O LO1415 O to O K.B.M O and O Czech B-ORG Science I-ORG Foundation I-ORG 13-28093S O to O K.B.M O This O research O was O supported O by O the O key B-ORG Program I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81430079 O regular B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81372962 O 81402658 B-AWARD 81273099 B-AWARD and O 81602877 B-AWARD the O National B-ORG “Twelfth I-ORG Five-Year I-ORG Plan” I-ORG for I-ORG Science I-ORG I-ORG Technology I-ORG 2014BAI12B01 O Guangdong B-ORG Province I-ORG Doctor I-ORG Staring I-ORG Program I-ORG Grant I-ORG 2016A030310163 O and O the O Young B-ORG Teachers I-ORG Training I-ORG Program I-ORG of I-ORG Sun I-ORG Yat-sen I-ORG University I-ORG Grant O number O 18ykpy14 B-AWARD The O funding O body O had O no O role O in O the O design O of O the O study O collection O analyses O and O interpretation O of O data O nor O in O writing O the O manuscript O This O work O was O supported O by O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG No. O XDB11040200 B-AWARD Major O State B-ORG Basic I-ORG Research I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 973 O Program O No. O 2014CB13840402 B-AWARD and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31371934 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 52278426 B-AWARD the O Department B-ORG of I-ORG Transportation I-ORG of I-ORG Sichuan I-ORG Province I-ORG No. O 2022-ZL-13 B-AWARD and O the O Research B-ORG Project I-ORG of I-ORG Sichuan I-ORG Road I-ORG I-ORG Bridge I-ORG Construction I-ORG Group I-ORG Co I-ORG Ltd I-ORG No. O KY2021srbg-10-11 B-AWARD The O authors O gratefully O acknowledge O their O financial O support O Funded O by O The O Key O Project O of O China O Social O Science O Foundation O 15AJL004 O Mr O Yongqing O Nan O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG CN O 71771052 B-AWARD Dr O Yanyan O Gao O The B-ORG Youth I-ORG project I-ORG of I-ORG MOE I-ORG Humanity I-ORG and I-ORG Social I-ORG Science I-ORG Foundation I-ORG CN O 17YJC790040 B-AWARD Dr O Yanyan O Gao O Basic B-ORG Research I-ORG Funds I-ORG for I-ORG China’s I-ORG Central I-ORG Universities O 2242017K40168 B-AWARD Dr O Yanyan O Gao O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 72061023 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Gansu I-ORG Province I-ORG China I-ORG grant O number O 20JR10RA173 B-AWARD the O Hongliu B-ORG Outstanding I-ORG Young I-ORG Talents I-ORG Support I-ORG Program I-ORG of I-ORG Lanzhou I-ORG University I-ORG of I-ORG Technology I-ORG 03200038 O and O the O Gansu B-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG Graduate I-ORG Student I-ORG “Innovation I-ORG Star” I-ORG Project I-ORG grant O number O 2023CXZX-463 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grants O no. O 81570376 B-AWARD and O no. O 81573231 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG grant O no. O 15ZR1424400 B-AWARD the O Three-year B-ORG Action I-ORG Plan I-ORG on I-ORG Public I-ORG Health I-ORG Phase I-ORG IV, I-ORG Shanghai I-ORG China I-ORG grant O no. O 15GWZK0801 B-AWARD SJTU B-ORG Interdisciplinary I-ORG Research I-ORG Key I-ORG grant O no. O YG2015ZD01 B-AWARD and O Shanghai B-ORG Municipal I-ORG Planning I-ORG Commission I-ORG of I-ORG Science I-ORG and I-ORG Research I-ORG Fund I-ORG grant O no. O 20144Y0249 B-AWARD The O funding O bodies O allowed O to O collect O analyze O interpret O the O data O and O write O the O manuscript O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Nos O 2021YFC2701901 B-AWARD and O 2016YFC1305301 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81570759 B-AWARD and O 81270938 B-AWARD and O Zhejiang B-ORG Provincial I-ORG Key I-ORG Disciplines I-ORG of I-ORG Medicine I-ORG Innovation O Discipline O No. O 11-CX24 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 51705240 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG of O China O Grant O No. O BK20170783 B-AWARD the O Aeronautical B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 2017ZC52037 B-AWARD the O State O Key O Laboratory O of O Robotics O and O System O HIT O Grant O No. O SKLRS-2018-KF-10 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31872194 B-AWARD and O the O China B-ORG Ocean I-ORG Mineral I-ORG Resources I-ORG Research I-ORG and I-ORG Development I-ORG Association I-ORG Program I-ORG DY135-E2-3-04 O the O Science B-ORG I-ORG Technology I-ORG Basic I-ORG Resources I-ORG Investigation I-ORG Program I-ORG of O China O No. O 2017FY201404 B-AWARD the O Strategic O Priority O Research O Program O of O the O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG XDA23050304 O the O Scientific O and O Technological O Innovation O Project O Financially O Supported O by O Qingdao B-ORG National I-ORG Laboratory I-ORG for I-ORG Marine I-ORG Science I-ORG and I-ORG Technology I-ORG No. O 2015ASKJ01 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82171671 O National O Natural O Science O Foundation O of O China O the O Scientific B-ORG Research I-ORG Common I-ORG Program I-ORG of I-ORG Beijing I-ORG Municipal I-ORG Commission I-ORG of I-ORG Education I-ORG KM202110025007 O Beijing O Municipal O Education O Commission O the O Beijing B-ORG Hospitals I-ORG Authority’ I-ORG Ascent I-ORG Plan I-ORG DFL20191402 O Beijing O Hospital O Authority O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC1000304 O Ministry O of O Finance O of O the O People’s O Republic O of O China O and O the O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 7222248 O Beijing O Municipal O Natural O Science O Foundation O Committee O This O material O is O based O upon O work O that O is O supported O by O the O National B-ORG Institute I-ORG of I-ORG Food I-ORG and I-ORG Agriculture O U.S O Department O of O Agriculture O under O award O number O 2015-67015-22961 B-AWARD and O by O the O UK B-ORG Biotechnology I-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG grant O number O BB/M027112/1 B-AWARD as O part O of O the O joint O NIFA-BBSRC O Animal O Health O and O Disease O program O This O project O is O the O result O of O funding O provided O by O United O States O Department O of O Homeland O Security O Science B-ORG and I-ORG Technology I-ORG Directorate’s O Homeland O Security O Advanced O Research O Projects O Agency O Chemical O and O Biological O Defense O Division O under O contract O number O D15PC00276 B-AWARD This O research O was O supported O by O USDA O Agricultural B-ORG Research I-ORG Service I-ORG Cooperative O Agreement O 58-5430-4-021 B-AWARD Work O was O also O supported O by O the O UK B-ORG Medical I-ORG Research I-ORG Council I-ORG MC_UU_12014 O AK O This O work O was O supported O by O the O British B-ORG Heart I-ORG Foundation I-ORG PG/12/81/29897 O to O P.M O RE/13/5/30177 B-AWARD and O FS/16/55/32731 B-AWARD the O Engineering B-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG EPSRC I-ORG EP/L014165/1 O to O P.M O the O European B-ORG Commission I-ORG Marie I-ORG Skłodowska-Curie I-ORG Individual I-ORG Fellowships I-ORG 661369 O to O P.M O the O Arthritis B-ORG Research I-ORG UK I-ORG RACE20298 O to O M.K.S O and O National B-ORG Institutes I-ORG of I-ORG Health I-ORG HL075662 O HL127464 B-AWARD and O HL132412 B-AWARD to O I.T O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31902279 O 31902284 B-AWARD Guangdong B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG Project I-ORG 2021A1515012388 O 2017A020208079 B-AWARD and O the O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG 2021A1515110322 O This O project O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81773489 O Social B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Subject I-ORG in I-ORG Chongqing I-ORG cstc2015shmszx120070 O the O Technology B-ORG Basic I-ORG and I-ORG Advanced I-ORG Research I-ORG Projects I-ORG in I-ORG Chongqing I-ORG cstc2014jcyjA10069 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O Financiadora B-ORG de I-ORG Estudos I-ORG e I-ORG Projetos I-ORG FINEP O Grant O 01.11.0098.03 O Fundação B-ORG de I-ORG Apoio I-ORG à I-ORG Pesquisa I-ORG I-ORG UFG I-ORG FUNAPE O Process O 52.073.001 O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG Goiás I-ORG FAPEG O Grant O 201410267001313 O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq O Grant O 550014/2013-6 O 383492/2014-9 B-AWARD Coordenação O de O Aperfeiçoamento O de O Pessoal O de O Nível O Superior O CAPES O and O Instituto O de O Ciências O Farmacêuticas O ICF O This O work O was O supported O by O an O Institutional O Development O Award O IDeA O from O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG NIGMS O of O the O National O Institutes O of O health O NIH O under O Grant O P20GM1033408 O Martin O O Schiele O and O 4U54GM104944-04TBD O Martin O NIH O National B-ORG Institute I-ORG of I-ORG Neurological I-ORG Disorders I-ORG and I-ORG Stroke I-ORG under O Grant O R01NS111283 O American B-ORG Heart I-ORG Association I-ORG under O Grant O 19TPA34860008 O to O BCWT O Tanner O and O National O Science O Foundation O under O Grant O 1656450 O to O BCWT O Tanner O This O work O was O supported O by O research O grants O from O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81271489 B-AWARD Hebei B-ORG Province I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.H20142062 O and O Government-funded B-ORG Program I-ORG for I-ORG Training I-ORG Excellent I-ORG Clinical I-ORG Medical I-ORG Talents I-ORG and I-ORG Fundamental I-ORG Research I-ORG LS201612 O The O research O in O A.D O lab O was O funded O by O German B-ORG Cancer I-ORG Aid I-ORG Deutsche O Krebshilfe O project O ID: O 70114659 B-AWARD and O Deutsche B-ORG Forschungsgemeinschaft I-ORG DFG O project O ID: O 491692296 B-AWARD and O 416001651 B-AWARD The O project O was O funded O by O the O German B-ORG Federal I-ORG Ministry I-ORG of I-ORG Education I-ORG and I-ORG Research I-ORG BMBF O TurbiCAR O project O ID: O 01EK1513A B-AWARD granted O to O M.B O and O by O the O Helmholtz B-ORG Initiative I-ORG and I-ORG Networking I-ORG Fund I-ORG Radio-Immunotheranostics O MHELTHERA O project O ID: O InterLabs-0031 B-AWARD granted O to O M.B O The O project O was O further O supported O by O the O Mildred B-ORG Scheel I-ORG Early I-ORG Career I-ORG Center I-ORG Dresden I-ORG P2/German I-ORG Cancer I-ORG Aid I-ORG Deutsche O Krebshilfe O project O ID: O 74MSNZNGAr B-AWARD granted O to O C.A O The O current O work O was O supported O by O grants O from O The B-ORG National I-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 81600222 B-AWARD to O YC O and O 81800255 B-AWARD to O MX O Young B-ORG experts I-ORG of I-ORG Taishan I-ORG Scholar I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG to O YC O tsqn201812142 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2018BH002 O to O MX O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O partly O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG 2021RC3086 O 2021JJ20001 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32272811 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2022YFD1700103 O and O the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG Project I-ORG CARS-01-02A O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81760376 B-AWARD for O LN, O the O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG grant O number O 7162031 B-AWARD for O FZ, O and O the O Peking B-ORG University I-ORG Shougang I-ORG Hospital I-ORG grant O numbers O 2017-Yuan-LC-08 B-AWARD SGYYZ201602 O for O SH. O The O authors O thank O Japan B-ORG Science I-ORG and I-ORG Technology I-ORG Agency I-ORG JST O AS262Z02450K B-AWARD the O Japan B-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG JSPS O 15K06508 B-AWARD and O IKETANI B-ORG Science I-ORG and I-ORG Technology I-ORG Foundation I-ORG 0271040-A O for O the O financial O support O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31372029 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Projects I-ORG 2019YFD1001605 O Key B-ORG R&D I-ORG Projects I-ORG in I-ORG Hebei I-ORG Province I-ORG 21326304D O National B-ORG Key I-ORG R&D I-ORG Program I-ORG Project I-ORG Funding I-ORG 2018YFD1000607 O Subsidy B-ORG Funds I-ORG of I-ORG Hebei I-ORG Jujube I-ORG Industry I-ORG Technology I-ORG Research I-ORG Institute I-ORG after I-ORG Operation I-ORG Performance I-ORG 205676155H O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG China I-ORG C2022402021 O C2017204114 B-AWARD Provincial B-ORG Graduate I-ORG Student I-ORG Innovation I-ORG Project I-ORG of I-ORG Hebei I-ORG CXZZBS2017072 O the O Science B-ORG and I-ORG Technology I-ORG Research I-ORG Project I-ORG of I-ORG University I-ORG in I-ORG Hebei I-ORG Province I-ORG QN2020205 O Science B-ORG and I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG Project I-ORG of I-ORG Handan I-ORG 19422011008–49 O Ph.D B-ORG Starting I-ORG Fund I-ORG of I-ORG the I-ORG Hebei I-ORG University I-ORG of I-ORG Engineering I-ORG SJ2101003172 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82272921 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG 22ZR1411000 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG 2022J011415 O This O study O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31501737 O and O 31570368 B-AWARD partly O supported O by O the B-ORG open I-ORG funds I-ORG of I-ORG the I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Crop I-ORG Genetics I-ORG and I-ORG Germplasm I-ORG Enhancement I-ORG ZW201711 O and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG KJQN201655 O The O funders O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.41471256 O Project B-ORG for I-ORG the I-ORG Training I-ORG of I-ORG Young I-ORG Backbone I-ORG Teachers I-ORG of I-ORG Higher I-ORG Education I-ORG Institutions I-ORG in I-ORG Henan I-ORG Province I-ORG 2018GGJS047 O Henan B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Project I-ORG 192102110050 O This O paper O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 62072020 B-AWARD the O Leading B-ORG Talents I-ORG in I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG of I-ORG Qingdao I-ORG 19-3-2-21-zhc O the O Independent B-ORG scientific I-ORG research I-ORG project I-ORG of I-ORG Beihang I-ORG Qingdao I-ORG Research I-ORG Institute I-ORG BQY2022VRC002 O and O the O Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG ZR2020MF132 O This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG 2016YFD0300608 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31601222 O 31725020 B-AWARD the O Academic B-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O and O the B-ORG project I-ORG for I-ORG Student I-ORG Research I-ORG Training I-ORG SRT I-ORG in I-ORG the I-ORG College I-ORG of I-ORG Agriculture I-ORG at I-ORG Nanjing I-ORG Agricultural I-ORG University I-ORG 1711A20 O The O Research B-ORG Development I-ORG Fund I-ORG for I-ORG Hematological I-ORG Neoplasm I-ORG from I-ORG Chinese I-ORG Anti-Cancer I-ORG Association I-ORG 312160342 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG for I-ORG Young I-ORG Scholars I-ORG grants O 81302148 B-AWARD L.Z O National B-ORG Institutes I-ORG of I-ORG Health I-ORG Grants O RO1CA050947 B-AWARD RO1CA207237 B-AWARD and O DF/HCC B-ORG SPORE I-ORG in I-ORG Multiple I-ORG Myeloma I-ORG P50CA100707 B-AWARD K.C.A O is O an O American O Cancer O Society O Clinical O Research O Professor O This O study O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31372317 O Developing B-ORG Key I-ORG Equipment I-ORG for I-ORG Digital I-ORG Management I-ORG and I-ORG Monitoring I-ORG Environment I-ORG in I-ORG Animal I-ORG Production I-ORG 2013AA10230602 O Prevention B-ORG and I-ORG Control I-ORG of I-ORG Nutritional I-ORG Metabolism I-ORG and I-ORG Toxic I-ORG Diseases I-ORG in I-ORG Livestock I-ORG and I-ORG Poultry I-ORG 2016YFD0501204 O and O the O 111 B-ORG Project I-ORG B16044 O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2021YFF1000400 O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG China I-ORG LQ22C020001 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31972486 O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2021FZZX001-28 O and O the B-ORG Ministry I-ORG of I-ORG Education I-ORG and I-ORG Bureau I-ORG of I-ORG Foreign I-ORG Experts I-ORG of I-ORG China I-ORG B14027 O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No: O 81401606 B-AWARD and O 81400862 B-AWARD the O Key B-ORG Project I-ORG in I-ORG the I-ORG Science I-ORG I-ORG Technology I-ORG Program I-ORG of I-ORG Sichuan I-ORG Province I-ORG Grant O No: O 19ZDYF1454 B-AWARD and O the O Science B-ORG Foundation I-ORG for I-ORG Excellent I-ORG Youth I-ORG Scholars I-ORG of I-ORG Sichuan I-ORG University I-ORG Grant O No: O 2015SU04A15 B-AWARD This O study O was O supported O by O Singapore-MIT B-ORG Alliance I-ORG for I-ORG Research I-ORG and I-ORG Technology I-ORG Centre I-ORG Grant O No. O ING000665-BIO B-AWARD National B-ORG University I-ORG Health I-ORG System I-ORG Grant O No. O NUHSRO/2019/085 B-AWARD and O National B-ORG Health I-ORG Innovation I-ORG Centre I-ORG Singapore I-ORG Grant O No. O NHIC B-AWARD I2D-1908233 O This O work O was O supported O by O the O Youth B-ORG scientific I-ORG research I-ORG of I-ORG health I-ORG and I-ORG family I-ORG planning I-ORG of I-ORG Fujian I-ORG province I-ORG Grant O number O 2017-1-65 B-AWARD Medical B-ORG innovation I-ORG project I-ORG of I-ORG Fujian I-ORG province I-ORG Grant O number O 2018-CX-38 B-AWARD and O Startup B-ORG Fund I-ORG for I-ORG scientific I-ORG research I-ORG Fujian I-ORG Medical I-ORG University I-ORG Grant O number O 2016QH010 B-AWARD This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31572469 O the B-ORG Earmarked I-ORG Fund I-ORG for I-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-44-KXJ15 O and O the O Jiangxi B-ORG Provincial I-ORG Education I-ORG Department I-ORG Research I-ORG Project I-ORG GJJ150415 O This O work O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O grant O 61971032 B-AWARD in O part O by O the O Hebei B-ORG Natural I-ORG Science I-ORG Foundation I-ORG under O grant O F2022402001 B-AWARD and O grant O A2020402013 B-AWARD and O in O part O by O the O Open B-ORG Fund I-ORG of I-ORG Chongqing I-ORG Engineering I-ORG Research I-ORG Center I-ORG of I-ORG Intelligent I-ORG Sensing I-ORG Technology I-ORG and I-ORG Microsystem I-ORG under O grant O D2021337 B-AWARD The O study O was O supported O by O grants O from O Joint B-ORG Funds I-ORG for I-ORG the I-ORG innovation I-ORG of I-ORG science I-ORG and I-ORG Technology I-ORG Fujian I-ORG province I-ORG 2019Y9017 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81601834 O 81702073 B-AWARD 81971996 B-AWARD 82030063 B-AWARD and O Startup B-ORG Fund I-ORG for I-ORG scientific I-ORG research I-ORG Fujian I-ORG Medical I-ORG University I-ORG 2016QH053 O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 52065049 B-AWARD 12064001 B-AWARD Jiangxi B-ORG Province I-ORG Funds I-ORG for I-ORG Distinguished I-ORG Young I-ORG youths O grant O number O 20212ACB214010 B-AWARD Jiangxi B-ORG Academic I-ORG and I-ORG Technical I-ORG Leaders I-ORG Training I-ORG Program I-ORG grant O number O 20204BCJL22039 B-AWARD 20225BCJ23023 B-AWARD Key B-ORG R I-ORG I-ORG D I-ORG plan I-ORG of I-ORG Jiangxi I-ORG Province O grant O number O 20212BBE51006 B-AWARD 20223BBE51034 B-AWARD Graduate B-ORG Innovation I-ORG Fund I-ORG Project I-ORG of I-ORG Nanchang I-ORG Hangkong I-ORG University O grant O number O YC2021-078 B-AWARD This O study O was O supported O by O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81771660 O given O to O Jian-ping O Zhang O for O microarray O analysis O Guangdong B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2018A030313023 O given O to O Hui O Chen O for O obtaining O qPCR O detection O reagents O and O RNA O extraction O reagents O Guangdong O Natural O Science O Foundation O 2018A030310162 O given O to O Li-qiong O Zhu O for O obtaining O qPCR O detection O reagents O and O RNA O extraction O reagents O and O Major B-ORG Program I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 2019YFA0801403 O given O to O Jian-ping O Zhang O for O obtaining O liquid O nitrogen O tank O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81471064 B-AWARD No. O 81670779 B-AWARD and O No. O 81870590 B-AWARD the O Beijing B-ORG Municipal I-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 7162097 B-AWARD and O No. O H2018206641 B-AWARD the O Peking B-ORG University I-ORG Research I-ORG Foundation I-ORG No. O BMU20140366 B-AWARD and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC1700402 O Y.J O received O funding O from O Student O Innovation O Training O Program O of O Peking O University O Health O Science O Center O for O this O study O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O 31700159 B-AWARD Young B-ORG Talent I-ORG Program I-ORG of I-ORG Higher I-ORG School I-ORG in I-ORG Hebei I-ORG Province I-ORG No. O BJ2020024 B-AWARD Scientific B-ORG Research I-ORG Foundation I-ORG for I-ORG High-level I-ORG Talents I-ORG of I-ORG Chengde I-ORG Medical I-ORG University I-ORG 202001 O and O Key B-ORG discipline I-ORG construction I-ORG of I-ORG colleges I-ORG and I-ORG universities I-ORG in I-ORG Hebei I-ORG Province I-ORG Ji O Jiao I-AWARD Gao I-AWARD No. I-AWARD 2013]4 O The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O the O preparation O of O the O manuscript O This O research O of O B.C O was O supported O by O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O funded O by O the O Ministry O of O Science O and O ICT O No.2022R1A2C1009516 O W.S O was O supported O by O the O internal O R&D O pro-gramme O at O KAERI B-ORG No.524460-23 O J.-S.R O was O supported O by O the O National O Research O Foundation O of O Korea O NRF O fund-ed O by O the O Ministry O of O Education O Science O and O Technology O NRF-2020K1A4A7A02095438 O NRF-2021R1A4A3029839 B-AWARD S.Y O was O supported O by O Korea B-ORG Institute I-ORG of I-ORG Industrial I-ORG Technology I-ORG KITECH O EO-23-0009 O This O research O was O funded O by O the O Scientific B-ORG Research I-ORG Projects I-ORG in I-ORG Colleges I-ORG and I-ORG Universities I-ORG in I-ORG Hebei I-ORG Province I-ORG ZD2022159 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG B2020508008 O and O the B-ORG Open I-ORG Project I-ORG Program I-ORG from I-ORG Petroleum I-ORG and I-ORG Chemical I-ORG Industry I-ORG Engineering I-ORG Laboratory I-ORG of I-ORG Non-halogen I-ORG Flame I-ORG Retardants I-ORG for I-ORG Polymers I-ORG Grant O No. O BTBUFR21-3 B-AWARD and O cooperated O with O Beijing O Technology O and O Business O University O China O This O work O was O supported O by O the O Key B-ORG Program I-ORG of I-ORG the I-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG nos O 2017YFA0106100 B-AWARD 2016YFY1101303 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Funds I-ORG for I-ORG Outstanding I-ORG Young I-ORG Scholar I-ORG no. O 81622027 B-AWARD the O Key B-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 31830030 B-AWARD and O the O Beijing B-ORG NOVA I-ORG Program I-ORG of I-ORG China I-ORG no. O 2016B615 B-AWARD Joint O funds O for O National O Natural O Science O Foundation O of O China O no. O U1601221 B-AWARD This O study O was O supported O in O the O design O of O the O study O by O a O grant O from O Shanghai B-ORG Municipal I-ORG Education I-ORG Commission—Gaofeng I-ORG Clinical I-ORG Medicine I-ORG Grant I-ORG Support I-ORG 20152235 O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC1310400 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U1502228 O 81771436 B-AWARD and O was O supported O in O the O data O collection O and O analysis O by O Shanghai B-ORG Municipal I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG joint I-ORG research I-ORG project I-ORG 2014ZYJB0002 O Shanghai B-ORG Key I-ORG Laboratory I-ORG of I-ORG Psychotic I-ORG Disorders I-ORG 13DZ2260500 O Program B-ORG of I-ORG Shanghai I-ORG Academic I-ORG Research I-ORG Leader I-ORG 17XD1403300 O key B-ORG subject I-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission(Psychiatry O 2017ZZ02021 O Key B-ORG Subject I-ORG Construction I-ORG of I-ORG Jiading I-ORG District I-ORG Mental I-ORG Health I-ORG JDYXZDZK-3 O This O work O was O partly O supported O by O the O Youth B-ORG Research I-ORG Fund I-ORG of I-ORG Xiamen I-ORG Cancer I-ORG Hospital I-ORG YL, O No. O ZLYYA201706 B-AWARD no O website O the O Nature B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG YL, O No. O 81101066,http://www.nsfc.gov.cn/english/site_1/index.html B-AWARD and O the O Berliner B-ORG Krebsgesellschaft I-ORG SZ, O ZSF201720,https://www.berliner-krebsgesellschaft.de B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 42176167 B-AWARD Innovation B-ORG Fund I-ORG of I-ORG Guangdong I-ORG Ocean I-ORG University I-ORG grant O no. O Q18307 B-AWARD the O stable O supporting O fund O of O Acoustics B-ORG Science I-ORG and I-ORG Technology I-ORG Laboratory I-ORG grant O no. O JCKYS2021604SSJS008 B-AWARD This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 51276044 B-AWARD Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province O grant O number O 2014A010105047 B-AWARD Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangzhou I-ORG City O grant O number O 201707010367 B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81970993 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG 2019J01297 O the O Medical O Innovation O Grant O of O Fujian O Province O 2019-CX-36 O and O Fujian B-ORG Medical I-ORG University I-ORG XRCZX2017019 O The O funders O had O no O role O in O the O design O of O the O study O in O the O collection O analyses O or O interpretation O of O data O in O the O writing O of O the O manuscript O or O in O the O decision O to O publish O the O results O This O work O was O in O part O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32101701 O 32170268 B-AWARD 32100214 B-AWARD National B-ORG 111 I-ORG Project I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG BP0820035 O D17009 B-AWARD and O Opening B-ORG Fund I-ORG of I-ORG Key I-ORG Laboratory I-ORG of I-ORG Forage I-ORG and I-ORG Endemic I-ORG Crop I-ORG Biology I-ORG Ministry I-ORG of I-ORG Education I-ORG FECBOF2021005 O This O study O was O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG projects I-ORG intergovernmental I-ORG cooperation I-ORG in I-ORG science I-ORG and I-ORG technology I-ORG of I-ORG China I-ORG No. O 2018YFE0126900 B-AWARD to O Jiansong O Ji O the O Key B-ORG Research I-ORG and I-ORG development I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. O 2018C03024 B-AWARD to O Jiansong O Ji O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81972283 O 81772596 B-AWARD to O X.L O Research O reported O in O this O article O was O partially O funded O through O a O Patient-Centered B-ORG Outcomes I-ORG Research I-ORG Institute I-ORG PCORI O Award O DI-2017C3-9005 O and O through O support O by O grant O number O 1R01HL146782-01 B-AWARD from O the O National B-ORG Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute O Dr. O Taveras’ O time O was O supported O by O grant O number O 1K24DK105989 B-AWARD from O the O National B-ORG Institute I-ORG of I-ORG Diabetes I-ORG and I-ORG Digestive I-ORG and I-ORG Kidney I-ORG Diseases O The O statements O in O this O article O are O solely O the O responsibility O of O the O authors O and O do O not O necessarily O represent O the O views O of O the O Patient-Centered O Outcomes O Research O Institute O PCORI O its O Board O of O Governors O or O Methodology O Committee O This O work O was O funded O by O the O Science B-ORG and I-ORG Technology I-ORG Development I-ORG Project I-ORG of I-ORG the I-ORG Jilin I-ORG Province I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG grant O no. O 20220202030NC B-AWARD the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG grant O no. O 2018YFD0201004 B-AWARD and O the O Earmarked B-ORG Fund I-ORG for I-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG of I-ORG MOF I-ORG and I-ORG MARA I-ORG grant O no. O CARS–04 B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2019YFA0802600 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81974244 O the O Hainan B-ORG Province I-ORG Clinical I-ORG Medical I-ORG Center I-ORG QWYH202175 O the O Research B-ORG and I-ORG Cultivation I-ORG Fund I-ORG of I-ORG Hainan I-ORG Medical I-ORG University I-ORG HYPY2020015 O and O the O Postgraduate B-ORG Research I-ORG I-ORG Practice I-ORG Innovation I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG KYCX21-2972 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31400680 O Grants B-ORG for I-ORG Scientific I-ORG Research I-ORG of I-ORG BSKY I-ORG XJ201322 O from O Anhui O Medical O University O Science B-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2012B010300021 O 2013B010404044 B-AWARD and O Education B-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2013KJCX0107 O The O study O was O funded O by O The B-ORG National I-ORG Natural I-ORG Science I-ORG Fund I-ORG of I-ORG China I-ORG 81701618/H1008 O Beijing B-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospital’s I-ORG Youth I-ORG Programme(QML20171301 O Beijing B-ORG Talents I-ORG Fund I-ORG 2014000021469G225 O Science B-ORG Foundation I-ORG of I-ORG Capital I-ORG Institute I-ORG of I-ORG Pediatrics(PY-2017-06 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81873490 B-AWARD No. O 81860072 B-AWARD the O Xinjiang B-ORG Uygur I-ORG Autonomous I-ORG Region I-ORG Graduate I-ORG Research I-ORG and I-ORG Innovation I-ORG Project I-ORG No. O XJ2019G183 B-AWARD the O Xinjiang B-ORG Medical I-ORG University I-ORG Graduate I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Project I-ORG No. O CXCY2018020 B-AWARD and O the O Tianshan B-ORG Innovative I-ORG Research I-ORG Team I-ORG Plan I-ORG No. O 2018D14006 B-AWARD The O work O was O supported O by O Scientific B-ORG research I-ORG foundation I-ORG of I-ORG Jiangsu I-ORG Provincial I-ORG 333 I-ORG Project I-ORG BRA2015541 O BRA2016555 O Medical B-ORG scientific I-ORG research I-ORG project I-ORG of I-ORG Jiangsu I-ORG Provincial I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG No. O H2018041 O Medical B-ORG youth I-ORG talent I-ORG projects I-ORG in I-ORG Jiangsu I-ORG Province I-ORG No. O QNRC2016314 O and O Postgraduate B-ORG Research I-ORG I-ORG Practice I-ORG Innovation I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O KYCX18_1497 O The O funding O body O had O no O further O role O in O study O design O and O collection O analysis O interpretation O of O data O or O in O writing O the O manuscript O This O work O was O supported O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81271914 B-AWARD Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. O 2019C03021 B-AWARD Key B-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. O 2018ZZ016 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG Nos O LGC19H200005 B-AWARD and O LY12H16025 O and O Health B-ORG Bureau I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG Nos O 2018KY110 O 2018KY482 O 2015RCA016 O and O 2015KYA143 B-AWARD This O research O was O funded O by O Fundació B-ORG La I-ORG Marató I-ORG TV3 I-ORG project O reference O 201630.10 B-AWARD and O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III I-ORG through I-ORG the I-ORG Fondo I-ORG de I-ORG Investigación I-ORG para I-ORG la I-ORG Salud I-ORG CIBEROBN O CB12/03/30038 I-AWARD and O Proyecto O Intramural O CIBER B-AWARD OBN18PI03 O which O are O co-funded O by O the O European B-ORG Regional I-ORG Development I-ORG Fund I-ORG C.R I-ORG was I-ORG funded I-ORG by I-ORG the I-ORG Youth I-ORG Guarantee I-ORG program I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG Innovation I-ORG and I-ORG Universities I-ORG of I-ORG the I-ORG Government I-ORG of I-ORG Spain I-ORG and I-ORG European I-ORG Social I-ORG Funds I-ORG PEJ2018-002452-A O M.Q.-L O was O granted O a O Health B-ORG Research I-ORG Institute I-ORG of I-ORG Balearic I-ORG Islands I-ORG IdISBa O pre-doctoral O grant O JUNIOR19-05 O The O funding O sponsors O had O no O role O in O the O design O of O the O study O in O the O collection O analyses O or O interpretation O of O the O data O in O the O writing O of O the O manuscript O or O in O the O decision O to O publish O the O results O This O research O was O funded O by O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation O grant O number O 2022M713403 B-AWARD the O Heilongjiang B-ORG Bayi I-ORG Agricultural I-ORG Reclamation I-ORG University I-ORG Doctoral I-ORG Start-Up I-ORG Fund O grant O numbers O XYB201812 B-AWARD and O XYB202111 B-AWARD and O the O University B-ORG Nursing I-ORG Program I-ORG for I-ORG Young I-ORG Scholars I-ORG with I-ORG Creative I-ORG Talents I-ORG in O Heilongjiang O Province O grant O number O UNPYSCT-2020038 B-AWARD This O work O was O supported O by O the O the O Ministry B-ORG of I-ORG Research I-ORG Innovation I-ORG and I-ORG Digitization I-ORG through O Program O 1—Development O of O the O national O research O and O development O system O Subprogram O 1.2—Institutional O Performance—Projects O to O finance O excellence O in O RDI O Contract O no. O 15PFE/2021 B-AWARD and O CCCDI—UEFISCDI B-ORG project O number O Contract O no. O PN-III-P2-2.1-PTE-2021-0675 B-AWARD and O Nucleu B-ORG Programme O Project O PN.19.23.01.01 B-AWARD Smart-Bi O This O work O was O supported O by O the O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG Doctoral O Research I-AWARD Award O Institute B-ORG of I-ORG Aboriginal I-ORG Peoples I-ORG Health I-ORG Manitoba O Network I-AWARD Environment I-AWARD for I-AWARD Aboriginal I-AWARD Health I-AWARD Research I-AWARD Award O Manitoba B-ORG Health I-ORG Research I-ORG Council I-ORG Graduate O Studentship O and O University O of O Manitoba O This O study O was O supported O by O the O “National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China” I-ORG No. O 2017YFC0505905 O the O “Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG China” I-ORG No. O ZR2017MC013 O No. B-AWARD ZR2014CM032 O and O the O “Research B-ORG Program I-ORG for I-ORG Key I-ORG Technologies I-ORG of I-ORG Sponge I-ORG City I-ORG Construction I-ORG and I-ORG Management I-ORG in I-ORG Guyuan I-ORG City”(No O SCHM-2018 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG #81572769 O 81872380 B-AWARD 81772869 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Chongqing I-ORG cstc2018jscx-mszdX0039 O and O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG #2017YFE0191700 O National B-ORG Science I-ORG Foundation I-ORG MCB-2026805 O to O J.I O United B-ORG States–Israel I-ORG Binational I-ORG Science I-ORG Foundation I-ORG 2020624 O to O Y.L O National B-ORG Institutes I-ORG of I-ORG Health I-ORG R35-GM130326 O to O J.I O Welch B-ORG Foundation I-ORG H-2104-20220331 O to O J.I O Funding O for O open O access O charge O National O Institutes O of O Health O The O project O was O supported O by O the O Charles B-ORG University I-ORG Project I-ORG PRIMUS/SCI/46 B-AWARD by O the O Grant B-ORG Agency I-ORG of I-ORG Charles I-ORG University I-ORG GAUK O 444217 O and O Charles B-ORG University I-ORG Research I-ORG Centre I-ORG Program I-ORG 204069 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O National B-ORG Significant I-ORG Science I-ORG Foundation I-ORG 2015ZX09J15102 O 1226 B-ORG Engineering I-ORG Health I-ORG Major I-ORG Project I-ORG AWS16J018 O and O 1226 B-ORG Engineering I-ORG Health I-ORG Key I-ORG Project I-ORG BWS17J028 O The O funding O bodies O played O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O supported O by O the O UK O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG BB/J010367/1 O and O the O UK O Zoonoses O and O Emerging O Livestock O Systems O Initiative O BB/L017679/1 O BB/L018926/1 B-AWARD and O BB/L018845/1 B-AWARD S.C O J.E.B.H O J.S O J.B O A.D O J.A.C O W.A.d.G O R.R.K O T.K O D.T.H O B.T.M O E.S.S O L.W O The O Wellcome B-ORG Trust I-ORG provided O supported O for O K.H O and O A.L O 095787/Z/11/Z O and O K.J.A O 096400/Z/11/Z O The O US O National B-ORG Institutes I-ORG of I-ORG Health I-ORG provided O support O for O J.A.C O R01AI121378 O and O M.P.R O R01AI121378 O K23AI116869 B-AWARD This O work O was O supported O by O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG 973 I-ORG of I-ORG China I-ORG No. O 2011CB100502),http://program.most.gov.cn B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41301530),http://www.nsfc.gov.cn O the O Scientific B-ORG and I-ORG Technological I-ORG Projects I-ORG of I-ORG Shenyang I-ORG City I-ORG Grant O No. O FF11-117-3-00)http://www.syscg.gov.cn B-AWARD and O the O Fifth B-ORG session I-ORG of I-ORG Geping I-ORG Green I-ORG Action-123 I-ORG Project I-ORG of I-ORG Liaoning I-ORG Environmental I-ORG Research I-ORG and I-ORG Education I-ORG No. O CEPF2012-123-1-7),http://www.cepfln.com/List.asp?ID=634 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Universität O Konstanz O the O Konstanz O Research O School O Chemical O Biology O KoRS-CB O and O by O grants O of O the O Deutsche B-ORG Forschungsgemeinschaft I-ORG DFG/SFB969 O TPA4 O the O Gordon B-ORG and I-ORG Betty I-ORG Moore I-ORG Foundation I-ORG GBMF O 4966 I-AWARD project I-AWARD DiaEdit O and O the O German-Israeli B-ORG Foundation I-ORG for I-ORG Scientific I-ORG Research I-ORG and I-ORG Development I-ORG GIF O No. I-AWARD G-1011-199.12/2008 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O We O acknowledge O the O financial O support O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG project O nos O 51502074 B-AWARD and O 61604051 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG project O nos O F2017202052 B-AWARD and O F2018202080 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Tianjin I-ORG City I-ORG project O no. O 16JCYBJC16200 B-AWARD Program B-ORG for I-ORG Top I-ORG 100 I-ORG Innovative I-ORG Talents I-ORG in I-ORG Colleges I-ORG and I-ORG Universities I-ORG of I-ORG Hebei I-ORG Province I-ORG project O no. O SLRC2017032 B-AWARD and O Program B-ORG for I-ORG 100-Talent-Plan I-ORG of I-ORG Hebei I-ORG Province I-ORG project O no. O E2016100010 B-AWARD This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 21576303 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG grant O nos O 2016A030313375 B-AWARD 2017A030311003 B-AWARD Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG China I-ORG grant O no. O 201903010011 B-AWARD This O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. I-AWARD 81972789 O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG Grant O No. I-AWARD 2018ZX10302205-004-002 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No. I-AWARD JUSRP22011 O Technology B-ORG Development I-ORG Funding I-ORG of I-ORG Wuxi I-ORG Grant O No. I-AWARD WX18IVJN017 O and O Research O Funding O from O DaBeiNong O Group O China O These O funding O sources O have O no O role O in O the O writing O of O the O manuscript O or O the O decision O to O submit O it O for O publication O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O no. O 31701967 B-AWARD CY O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province O China O Grant O No. O LQ17C150003 B-AWARD CY O the B-ORG young I-ORG talent I-ORG training I-ORG project I-ORG of I-ORG Zhejiang I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG 2016R23R08E05 O CY O and O the B-ORG Research I-ORG Project I-ORG of I-ORG seed I-ORG and I-ORG seedling I-ORG of I-ORG Wenzhou I-ORG City I-ORG No. O Z20160009 B-AWARD LZ O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grant O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81573014 O 81402250 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG 2016JJ2171 O Key B-ORG Projects I-ORG of I-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG in I-ORG China I-ORG 2016YFC0902000 O and O Open B-ORG Funds I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Oncology I-ORG in I-ORG South I-ORG China I-ORG HN2016-01 O This O research O was O funded O by O Anhui B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation O grant O number O 2208085MD101 B-AWARD and O the O Provincial B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Anhui O grant O number O 2018085QD171 B-AWARD and O the O Key B-ORG Project I-ORG of I-ORG Natural I-ORG Science I-ORG Research I-ORG in I-ORG Universities I-ORG of I-ORG Anhui I-ORG Province O grant O number O KJ2021A0443 B-AWARD and O the O Open B-ORG Research I-ORG Fund I-ORG of I-ORG Coal I-ORG Industry I-ORG Engineering I-ORG Research I-ORG Center I-ORG of I-ORG Collaborative I-ORG Monitoring I-ORG of I-ORG Mining I-ORG Area’s I-ORG Environment I-ORG and I-ORG Disasters O grant O number O KSXTJC202006 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Research I-ORG Project I-ORG of I-ORG Colleges I-ORG and I-ORG Universities I-ORG in I-ORG Hebei I-ORG Province O grant O number O ZD2021023 B-AWARD and O Major B-ORG science I-ORG and I-ORG technology I-ORG projects I-ORG of I-ORG Anhui I-ORG Province O grant O number O 202103a05020026 B-AWARD and O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Anhui I-ORG Province O grant O number O 202104a07020014 B-AWARD This O research O work O was O supported O by: O Basic B-ORG research I-ORG business I-ORG funding I-ORG project I-ORG of I-ORG public I-ORG welfare I-ORG research I-ORG institutes I-ORG in I-ORG Xinjiang I-ORG Uygur I-ORG Autonomous I-ORG Region O KY2021116/KY2022020;Key B-AWARD R&D I-ORG projects I-ORG in I-ORG Xinjiang I-ORG Uygur I-ORG Autonomous I-ORG Region O 2022B02048;National B-AWARD key I-ORG R&D I-ORG plan O 2022YFD1000104-02 B-AWARD This O study O was O supported O by O National B-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG of I-ORG China I-ORG 81170747 O and O the O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O JX10231801 O in O the O design O of O the O study O and O collection O and O by O National O Natural O Sciences O Foundation O of O China O 81670723 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20161589 O during O the O process O of O data O analysis O and O interpretation O as O well O as O writing O the O manuscript O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFA090039 O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21978071 O U1932141 B-AWARD the O Leading O Innovative O and O Entrepreneur O Team O Introduction O Program O of O Zhejiang O Province O 2018R01014 O and O the O Technical B-ORG Innovation I-ORG Special I-ORG Fund I-ORG of I-ORG Hubei I-ORG Province I-ORG 2019AHB055 O 2018ACA149 B-AWARD We O also O acknowledge O the O support O from O State O Key O Laboratory O of O Biocatalysis O and O Enzyme O Engineering O Hubei O University O This O paper O was O partly O supported O by O NSAF B-ORG under O Grant O No. B-AWARD U1530118 O partly O by O National O High O Technology O of O China O “863 O program” O under O Grant O No. O 2015AA015702 O partly O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG under O Grant O No.2018YFB1702001 B-AWARD and O partly O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O No. B-AWARD 61771040 I-AWARD This O work O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Province I-ORG grant O number O 2208085MC81 B-AWARD the O Project B-ORG of I-ORG Modern I-ORG Agricultural I-ORG Industry I-ORG and I-ORG Technology I-ORG System I-ORG of I-ORG Anhui I-ORG Province I-ORG grant O number O AHCYJSTX-05-03 B-AWARD and O the O College B-ORG Students I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Training I-ORG Program I-ORG of I-ORG Anhui I-ORG Agricultural I-ORG University I-ORG grant O number O X202210364415 B-AWARD DSH O DH, O VR, O and O CSG O were O supported O by O Grant O G-2018-11163 B-AWARD from O the O Alfred B-ORG P. I-ORG Sloan I-ORG Foundation I-ORG and O Grant O GBMF4552 B-AWARD from O the O Gordon B-ORG and I-ORG Betty I-ORG Moore I-ORG Foundation O VSM O was O supported O by O Grant O RP150596 B-AWARD from O the O Cancer B-ORG Prevention I-ORG and I-ORG Research I-ORG Institute I-ORG of I-ORG Texas O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0902400 O the B-ORG State I-ORG Key I-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG of I-ORG China I-ORG 81530077 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81602543 O 81672839 B-AWARD 81372317 B-AWARD 81472676 B-AWARD 81772551 B-AWARD and O 81572823 B-AWARD the B-ORG Projects I-ORG from I-ORG the I-ORG Shanghai I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG 14DZ1940300 O 14411970200 B-AWARD and O “Strategic B-ORG Priority I-ORG Research I-ORG Program” I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDA12020103 O and O XDA12020105 B-AWARD The O funding O body O had O put O into O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O Supported O by O the O Austrian B-ORG Science I-ORG Fund I-ORG FWF I-ORG grant O P22521-B18 B-AWARD to O A.H O and O the O Austrian B-ORG National I-ORG Bank I-ORG grant O 14263 B-AWARD to O A.H O K.J O was O funded O by O the O PhD B-ORG Program I-ORG DK-MOLIN I-ORG FWF-W1241 O The O National B-ORG Key I-ORG R&D I-ORG Program I-ORG 2016YFD0500100 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31502097 O the O Scientific B-ORG and I-ORG Technological I-ORG Project I-ORG of I-ORG Henan I-ORG Province I-ORG 182102110240 O and O the O Foundation B-ORG of I-ORG Nanyang I-ORG Normal I-ORG University I-ORG 15082 O supported O this O study O Tao O Chen O was O funded O by O China O Scholarship O Council O CSC O This O work O was O supported O by O Sino-German O NSFC-DFG O Cooperative O Research O Project O No. O 31861133013 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31771443 B-AWARD the O Basic O Research O Grant O from O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Commission I-ORG of I-ORG Shenzhen I-ORG Municipal I-ORG Government I-ORG No.KQTD20180411143432337 O and O No. O JCYJ20170307105752508 B-AWARD The O receiver O of O these O three O funds O is O Wei O Chen O NSFC:http://www.nsfc.gov.cn/english/site_1/index.htmlCSC:https://www.chinesescholarshipcouncil.comScience O and O Technology O Innovation O Commission O of O Shenzhen O Municipal O Government:http://english.sz.gov.cn/govt/agencies/s/201811/t20181122_14604925.htmThe O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O FONDECYT B-ORG 1130049 B-AWARD 1170291 B-AWARD to O H.E.L O DICYT_USACH B-ORG 022091BP-MED B-AWARD to O R.B O and O Conicyt B-ORG grant O for O doctoral O thesis O 21120077 B-AWARD to O B.P O This O work O was O supported O in O part O by O the O National B-ORG Cancer I-ORG Center I-ORG Research I-ORG and I-ORG Development I-ORG Fund I-ORG 29-A-3 O by O Japan B-ORG Agency I-ORG for I-ORG Medical I-ORG Research I-ORG and I-ORG Development I-ORG under O Grant O Number O JP17ck0106336 B-AWARD and O by O Japan B-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science O grant O number O 18 B-AWARD K09110 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No: O 81460325 B-AWARD and I-AWARD 81760384 O the B-ORG Applied I-ORG Basic I-ORG Research I-ORG in I-ORG Yunnan I-ORG Province I-ORG Grant O No: O 2015FB040 B-AWARD the B-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG in I-ORG Yunnan I-ORG province(Grant O No:2017NS030 O The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Eunice B-ORG Kennedy I-ORG Shriver I-ORG National I-ORG Institute I-ORG of I-ORG Child I-ORG Health I-ORG and I-ORG Human I-ORG Development I-ORG NICHD O Global O Network O for O Women’s O and O Children’s O Health O Research O HD034216 O the O National B-ORG Institute I-ORG of I-ORG Neurological I-ORG Disorders I-ORG and I-ORG Stroke I-ORG HD43464 O HD42372 I-AWARD HD40607 O and O HD40636 B-AWARD the O Fogarty B-ORG International I-ORG Center I-ORG TW006703 O the O Perinatal O Health O and O Human O Development O Research O Program O and O the O Children’s O of O Alabama O Centennial O Scholar O Fund O of O the O University O of O Alabama O at O Birmingham O W.C O is O on O the O Mednax O Board O of O Directors O Project O support O was O provided O by O the B-ORG Modern I-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG CARS-45 O the B-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG CAAS-ASTIP-2016-IAR O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31372384 B-AWARD and O the O Fundamental O Research O Funds O of O Institute O of O Apicultural O Research,CAAS O Grant O No. O 16089 O This O work O was O supported O by O the O U.S B-ORG Environmental I-ORG Protection I-ORG Agency I-ORG FP-91750801-1 O and O RD-83543301 B-AWARD the O National B-ORG Science I-ORG Foundation I-ORG Systems O Approach O to O Green O Energy O 1144885 O and O the O National B-ORG Institute I-ORG of I-ORG Environmental I-ORG Health I-ORG Sciences I-ORG P01-ES022841 O and O 1R56ES019598-01 B-AWARD These O funding O sources O had O no O involvement O in O the O conduct O of O the O research O or O preparation O of O this O article O This O work O was O supported O by O the O grants O from O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangzhou I-ORG City I-ORG 201504010017 O and O Guangdong B-ORG Province I-ORG 2018B020203001 O and O the O Ten-Thousand B-ORG Talents I-ORG Program I-ORG of I-ORG China I-ORG W03020593 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 62064005 B-AWARD the O Double B-ORG Thousand I-ORG Plan I-ORG of I-ORG Jiangxi I-ORG Province I-ORG grant O no. O jxsq2018101019 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Province I-ORG grant O no. O 20192ACB20006 B-AWARD and O the O Scientific B-ORG Research I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG grant O no. O 205200100100 B-AWARD This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province O China O Grant O No. O BK20191309 B-AWARD and O Shanghai B-ORG Agriculture I-ORG Applied I-ORG Technology I-ORG Development I-ORG Program I-ORG grant O number O G2016060201 B-AWARD and O the O project O funded O by O the O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O The O funders O had O no O use O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O No. O 81272688 B-AWARD the O Social B-ORG Programs I-ORG and I-ORG People’s I-ORG Livelihood I-ORG Guarantee I-ORG Innovation I-ORG Project I-ORG of I-ORG Chongqing I-ORG No. O cstc2016shms-ztzx130001 B-AWARD and O the O Clinical B-ORG Innovation I-ORG Fund I-ORG of I-ORG Southwest I-ORG Hospital I-ORG No. O SWH2015LC02 B-AWARD The O funding O sources O had O no O role O in O study O design O collection O analysis O or O interpretation O of O data O or O the O writing O of O the O report O or O the O decision O to O submit O the O report O for O publication O The O authors O declare O that O we O have O no O conflict O of O interest O to O disclose O This O study O is O supported O by O grants O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFC0905102 B-AWARD 2017YFC1001700 B-AWARD 2019YFC1005100 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81471097 O and O Beijing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG No. O Z141107004414036 B-AWARD Z151100003915126 B-AWARD This O work O was O supported O by O Grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 30900650 O 81372501 B-AWARD 81572260 B-AWARD 81871994 B-AWARD 81701834 B-AWARD and O 81773299 B-AWARD the B-ORG Guangdong I-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2011B031800025 O S2012010008378 B-AWARD 2015A030313036 B-AWARD and O 2015A030313036 O and O the B-ORG Guangzhou I-ORG and I-ORG Guangdong/Guangzhou I-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Program I-ORG 2014J4100132 O 2012B031800115 B-AWARD 2013B02180021 B-AWARD 2015A020214010 B-AWARD 2016A020215055 B-AWARD 201704020094 B-AWARD 2018A050506036 B-AWARD 16ykjc08 B-AWARD and O 2015ykzd07 B-AWARD This O work O was O supported O by O the O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG NHMRC I-ORG of I-ORG Australia I-ORG via I-ORG an I-ORG Early I-ORG Career I-ORG Research I-ORG Fellowship I-ORG to I-ORG RVS I-ORG 1072771 O a O project O grant O to O AS, B-ORG NMB I-ORG and I-ORG IDC I-ORG 1026005 O a O program O grant O to O IDC O 1037786 O and O a O Senior B-ORG Research I-ORG Fellowship I-ORG to I-ORG AS I-ORG 1042555 O We O are O also O grateful O to O the O Endocrine O Society O of O Australia O for O a O Postdoctoral O Award O to O RVS O and O to O the O Australian O Research O Council O for O an O Australian O Postgraduate O Award O to O AAG O Wellcome B-ORG Trust I-ORG 105281/Z/14/Z O 099684/Z/12/Z O Medical B-ORG Research I-ORG Council I-ORG 4050189188 O and O National B-ORG Institutes I-ORG of I-ORG Health I-ORG R24DK106766 O Funding O to O pay O the O Open O Access O publication O charges O for O this O article O was O provided O by O the O Wellcome O Trust O This O work O is O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51777171 O 81803032 B-AWARD the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 3102017OQD111 O the B-ORG Northwestern I-ORG Polytechnical I-ORG University I-ORG Foundation I-ORG for I-ORG Fundamental I-ORG Research I-ORG 3102018JGC012 O and O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Shenzhen I-ORG of I-ORG China I-ORG JCYJ20170412140904406 O This O work O was O supported O by O grants O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YED0201003 B-AWARD the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-25 O and O the O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG CAASASTIPIVFCAAS O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O study O received O fund O support O from O Clinical B-ORG research I-ORG incubation I-ORG project I-ORG Beijing I-ORG Chaoyang I-ORG Hospital I-ORG Capital I-ORG Medical I-ORG University I-ORG grant O number O CYFH202218 B-AWARD Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG grant O number O L202006 B-AWARD and O Key B-ORG R&D I-ORG Program I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG grant O number O 2019YFC0120604 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 62272362 B-AWARD U19B2021 B-AWARD the O Open B-ORG Research I-ORG Fund I-ORG of I-ORG Key I-ORG Laboratory I-ORG of I-ORG Cryptography I-ORG of I-ORG Zhejiang I-ORG Province I-ORG ZCL21016 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG XJS220122 O This O work O was O supported O by O the B-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG of I-ORG Guangzhou I-ORG No. O 201904010264 B-AWARD the B-ORG special I-ORG fund I-ORG for I-ORG Scientific I-ORG Innovation I-ORG Strategy I-ORG Construction I-ORG of I-ORG High I-ORG Level I-ORG Academy I-ORG of I-ORG Agriculture I-ORG Science I-ORG No. O R2019PY-QY003 B-AWARD Emerging B-ORG Discipline I-ORG Team I-ORG Project I-ORG of I-ORG Guangdong I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG No. O 201806xx B-AWARD and O Provincial B-ORG Rural I-ORG Revitalization I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2020KJ148 O This O research O was O funded O by O the O Swedish B-ORG Brain I-ORG Foundation I-ORG and O the O Mellby O Gård O Foundation O grant O numbers O FO2020-0006 B-AWARD and O FO2022-0001 B-AWARD The O Swedish B-ORG Research I-ORG Council I-ORG grant O number O 2017-01096 B-AWARD Region B-ORG Stockholm I-ORG ALF O project O grant O number O 20200095 B-AWARD and O Karolinska B-ORG Institutet I-ORG Research I-ORG Funds I-ORG grant O number O 2020-01411 B-AWARD This O work O was O supported O by O grants O from O the O British B-ORG Heart I-ORG Foundation I-ORG Project O Grants O PG/15/35/31403 B-AWARD PG/13/96/30608 B-AWARD BHF-DZHK O grant O SP/19/2/344612 B-AWARD Programme O Grants O RG/17/10/32859 B-AWARD RG/12/5/29576 B-AWARD and O Chair O Award O CH/16/1/32013 B-AWARD Wellcome B-ORG Trust I-ORG 090532/Z/09/Z O BHF B-ORG Centre I-ORG of I-ORG Research I-ORG Excellence I-ORG Oxford I-ORG RE/13/1/30181 O and O RE/18/3/34214 B-AWARD the O National O Institute O for O Health O Research O NIHR O Oxford O Biomedical O Research O Centre O the O National O Institute O for O Health O Research O NIHR O Leicester O Biomedical O Research O Centre O the O National O Institute O for O Health O Research O NIHR O Rare O Disease O Translational O Collaboration O and O Beat O SCAD O This O research O was O funded O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0201100 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31570136 O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-13 O This O work O was O partly O financially O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2018B030311022 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51574205 O and O 22002142 B-AWARD the O Guangdong B-ORG Innovation I-ORG Research I-ORG Team I-ORG for I-ORG Higher I-ORG Education I-ORG 2017KCXTD030 O the O High B-ORG level I-ORG Talents I-ORG Project I-ORG of I-ORG Dongguan I-ORG University I-ORG of I-ORG Technology I-ORG KCYKYQD2017017 O the O Engineering B-ORG Research I-ORG Center I-ORG of I-ORG None-Food I-ORG Biomass I-ORG Efficient I-ORG Pyrolysis I-ORG and I-ORG Utilization I-ORG Technology I-ORG of I-ORG Guangdong I-ORG Higher I-ORG Education I-ORG Institutes I-ORG 2016GCZX009 O and O the O Program O from O Dongguan O University O of O Technology O G200906-17 O This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG LY19H290003 O LQ20H280002 B-AWARD the O Zhejiang B-ORG Provincial I-ORG Medical I-ORG and I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 2020KY196 O 2018277310 B-AWARD the O Foundation B-ORG of I-ORG Zhejiang I-ORG province I-ORG Chinese I-ORG medicine I-ORG science I-ORG and I-ORG technology I-ORG planes I-ORG 2017ZB030 O 2020ZA044 B-AWARD and O Key B-ORG project I-ORG of I-ORG the I-ORG 2017 I-ORG school I-ORG research I-ORG fund I-ORG of I-ORG Zhejiang I-ORG Chinese I-ORG Medical I-ORG University I-ORG 2017ZZ02 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O financially O by O the O Swedish B-ORG Research I-ORG Council I-ORG Grant O No. O 2018–02599 B-AWARD theSwedishInitiative O for O Research O onMicrodata O in O theSocialAndMedical O Sciences O SIMSAM O framework O Grant O No. O 340–2013-5867 B-AWARD and O European B-ORG Union’s I-ORG Horizon I-ORG 2020 I-ORG research I-ORG and I-ORG innovation I-ORG programme I-ORG Grant O Aggreement O No. O 667302 B-AWARD This O work O was O supported O by O the O grants O of O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG NO.2021YFC2301000 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO.81971342 O and O the O Clinical O Medicine O Plus O X-Young O Scholars O Project O of O Peking B-ORG University I-ORG NO.PKU2020LCXQ021 O Funding O support O from O Outstanding B-ORG Youth I-ORG Talent I-ORG Program I-ORG of I-ORG Jiangxi I-ORG Province I-ORG 20171BCB23060 O Education B-ORG Department I-ORG Project I-ORG of I-ORG Jiangxi I-ORG Province I-ORG GJJ160478 O China B-ORG Scholarship I-ORG Council I-ORG 201808360317 O Jiangxi B-ORG Association I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG JAST O and O Doctor B-ORG Start-up I-ORG Project I-ORG 368 O This O project O was O sponsored O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81772425 O 31771017 B-AWARD 31972924 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG 16441908700 O the O Innovation O Research O Plan O supported O by O Shanghai O Municipal O Education O Commission O ZXWF082101 O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0110700 O 2019YFC0120600 B-AWARD and O the O Interdisciplinary O Program O of O Shanghai B-ORG Jiao I-ORG Tong I-ORG University I-ORG YG2016MS11 O JYYQ201516 B-AWARD YG2017MS09 B-AWARD ZH2018QNA06 B-AWARD W.S O and O G.Z O were O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG no. O 2014JM2-2020 B-AWARD X.G O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 81601596 B-AWARD Y.L O and O G.F O were O supported O by O Industrial B-ORG Science I-ORG and I-ORG technology I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 2014K08-12 O This O work O was O supported O by O grants O from O the O Ministry B-ORG of I-ORG Health I-ORG and I-ORG Welfare I-ORG Taiwan I-ORG MOHW107-TDU-B-212-123004 O China B-ORG Medical I-ORG University I-ORG Hospital I-ORG Academia I-ORG Sinica I-ORG Stroke I-ORG Biosignature I-ORG Project I-ORG BM10701010021 O MOST B-ORG Clinical I-ORG Trial I-ORG Consortium I-ORG for I-ORG Stroke I-ORG MOST O 106-2321-B-039-005).” O Tseng-Lien O Lin O Foundation O Taichung O Taiwan O and O Katsuzo O and O Kiyo O Aoshima O Memorial O Funds O Japan O Foundation O Taichung O Taiwan O and O Katsuzo O and O Kiyo O Aoshima O Memorial O Funds O Japan O WC O received O the O funding O The O funders O had O no O role O in O study O design O data O collection O data O analysis O data O interpretation O or O writing O of O the O report O The O corresponding O authors O had O full O access O to O all O data O in O the O study O and O had O final O responsibility O for O the O decision O to O submit O for O publication O This O work O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81971684 O 81771908 O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG No. O 2020A1515010571 O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province O PR O China O 2011B031800096 O Medical B-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG PR I-ORG China I-ORG A2019092 O and O Guangzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG No. O 201903010073 O The O Grants-in-Aid O just O supported O this O study O financially O and O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O sponsored O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG 16ZR1431600 O Pudong B-ORG New I-ORG Area I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Foundation I-ORG PKJ2016-Y40 O Seed B-ORG Fund I-ORG of I-ORG Shanghai I-ORG University I-ORG of I-ORG Medicine I-ORG I-ORG Health I-ORG Sciences I-ORG HMSF-17-21-029 O Projects B-ORG of I-ORG Medical I-ORG and I-ORG Health I-ORG Technology I-ORG Program I-ORG in I-ORG Zhejiang I-ORG Province I-ORG 2018PY079 O Fund B-ORG for I-ORG the I-ORG Key I-ORG Subject I-ORG Construction I-ORG of I-ORG Sanitary I-ORG System I-ORG of I-ORG Shanghai I-ORG Pudong I-ORG New I-ORG District I-ORG PWZxq2017-12 O Special B-ORG Fund I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Development I-ORG of I-ORG Pudong I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG PW2016A-21 O and O Fund B-ORG for I-ORG the I-ORG Most I-ORG Important I-ORG Discipline I-ORG Construction I-ORG of I-ORG Zhoupu I-ORG Hospital I-ORG of I-ORG Shanghai I-ORG Pudong I-ORG New I-ORG District I-ORG ZP-XK-2015a-2 O The O present O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O No.813002141 O the O Guangdong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG grant O No. O 2017A030313685 B-AWARD and O the O Guangdong B-ORG Provincial I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG Bureau I-ORG of I-ORG Scientific I-ORG Research I-ORG Projects I-ORG grant O No. O KY040217 B-AWARD 2017 O This O work O was O supported O by O the O Consejo B-ORG Nacional I-ORG de I-ORG Ciencia I-ORG y I-ORG Tecnología I-ORG CONACYT I-ORG who O provided O scholarship O no. O 84015/84015 B-AWARD to O V O Monroy-Velazquez O All O surveys O were O funded O by O CONABIO B-ORG Grant O LH010 B-AWARD Invertebrados I-AWARD del I-AWARD Parque I-AWARD Nacional I-AWARD Arrecife I-AWARD Puerto I-AWARD Morelos O and O by O DGAPA-UNAM B-ORG Grant O IN205314 B-AWARD ¿Puede O la O criptofauna O de O crustáceos O indicar O el O estado O de O conservación O de O un O arrecife O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Wellcome B-ORG Trust I-ORG 097720/Z/11/Z O C.J.P O the O Medical B-ORG Research I-ORG Council I-ORG MR/M023672/1 O C.J.P O and O the O Stroke B-ORG Association I-ORG TSA O 2014/02 I-AWARD C.J.P O D.L.L.-P O CONICYT O BECAS-CHILE O 72140131 B-AWARD and O A.G.-V O CONICYT O BECAS-CHILE O 73101009 B-AWARD were O funded O by O the O Chilean O national O commission O for O scientific O and O technological O research O CONICYT O through O its O scholarship O scheme O for O graduate O studies O abroad O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81101360 O the O Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG Fund I-ORG 16ZR1422000 O and O 18411964500 B-AWARD the O Shanghai B-ORG Jiaotong I-ORG University I-ORG Medical I-ORG and I-ORG Industrial I-ORG Cross I-ORG Fund I-ORG YG2015MS67 O and O the O Shanghai B-ORG Sailing I-ORG Program I-ORG 18YF1415700 O The O study O was O sponsored O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81570317 O and O 81100075 B-AWARD Research B-ORG Fund I-ORG for I-ORG the I-ORG Doctoral I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG China I-ORG 20100071120074 O Research B-ORG Fund I-ORG of I-ORG Fudan I-ORG University I-ORG China I-ORG 20520133376 O the B-ORG Youth I-ORG Science I-ORG Funds I-ORG of I-ORG the I-ORG Shanghai I-ORG Municipal I-ORG Health I-ORG Bureau I-ORG Shanghai I-ORG China I-ORG 2010Y029 O and O Youth B-ORG Science I-ORG Funds I-ORG of I-ORG Zhongshan I-ORG hospital O Shanghai O China O KB363 O This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81570726 O 81600609 B-AWARD Shanghai O Jiao O Tong O University O School O of O Medicine O 2014 O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG 16411971200 O 16410723200 B-AWARD Commission B-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG of I-ORG Pudong I-ORG District I-ORG PW2015D-5 O the B-ORG Fourth I-ORG Round I-ORG of I-ORG Three-Year I-ORG Public I-ORG Health I-ORG Action I-ORG Plan I-ORG of I-ORG Shanghai I-ORG by I-ORG the I-ORG Shanghai I-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG 15GWZK0202 O 20164Y0079 B-AWARD Municipal B-ORG Human I-ORG Resources I-ORG Development I-ORG Program I-ORG for I-ORG Outstanding I-ORG Young I-ORG Talents I-ORG in I-ORG Medical I-ORG and I-ORG Health I-ORG Sciences I-ORG in I-ORG Shanghai I-ORG 2017YQ053 O Clinical B-ORG Research I-ORG Plan I-ORG of I-ORG SHDC I-ORG 16CR3076B O The O funders O played O no O role O in O the O design O or O conduct O of O the O study O collection O management O analysis O or O interpretation O of O data O or O in O the O preparation O review O or O approval O of O the O article O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31872464 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0501200 O the O Natural O Science O Foundation O from O Jiangsu O Province O BZ2019013 O and O the O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O The O funding O bodies O played O no O role O in O the O design O of O the O study O the O collection O analysis O and O interpretation O of O data O and O in O writing O of O the O manuscript O This O work O was O supported O by O The B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51774173 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province I-ORG No. O 201602351 O and O the O Open B-ORG Fund I-ORG for I-ORG the I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Seismological I-ORG Dynamics I-ORG No. O LED2015B01 O to O BJ. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0500502 O The O Special B-ORG Fund I-ORG for I-ORG Pig I-ORG Industry I-ORG Technology I-ORG Innovation I-ORG Team I-ORG of I-ORG Modern I-ORG Agricultural I-ORG Industry I-ORG Technology I-ORG System I-ORG in I-ORG Tianjin I-ORG City I-ORG ITTPRS2017001 O and O The B-ORG Tianjin I-ORG “131” I-ORG Innovative I-ORG Talents I-ORG Team I-ORG 20180338 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O study O was O supported O by O the O National B-ORG Key I-ORG Technologies I-ORG R&D I-ORG Program I-ORG for I-ORG the I-ORG 13th I-ORG Five-Year I-ORG Plan I-ORG Grant O No. O 2017ZX10202101 B-AWARD the B-ORG National I-ORG Key I-ORG Technologies I-ORG R&D I-ORG Program I-ORG for I-ORG the I-ORG 12th I-ORG Five-Year I-ORG Plan I-ORG Grant O No. O 2012ZX10001003–001 B-AWARD the B-ORG National I-ORG Key I-ORG Technologies I-ORG R&D I-ORG Program I-ORG for I-ORG the I-ORG 11th I-ORG Five-Year I-ORG Plan I-ORG Grant O No. O 2008ZX10001006–001 B-AWARD and O the B-ORG CAMS I-ORG Initiative I-ORG for I-ORG Innovative I-ORG Medicine I-ORG CAMS-I2M O 2017-I2M-1-014 O The O funding O bodies O played O no O role O in O the O design O of O the O study O data O collection O data O analysis O interpretation O of O data O or O writing O of O the O manuscript O This O work O was O funded O by O The O Victorian O Government’s O Operational O Infrastructure O Support O Program O Murdoch O Children’s O Research O Institute O Royal O Children’s O Hospital O Foundation O Martin O O E.H O Flack O Trust O Pierce O Armstrong O Trust O Financial B-ORG Markets I-ORG Foundation I-ORG for I-ORG Children I-ORG Australia O FMFC O grant O number O 2017-361 B-AWARD and O the O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG NHMRC O project O grant O numbers O 1049299 B-AWARD and I-AWARD 1103389 O D.E O Godler O was O supported O by O the O Next O Generation O Clinical O Researchers O Program—Career O Development O Fellowship O Funded O by O the O Medical B-ORG Research I-ORG Future I-ORG Fund I-ORG grant O number O 1141334 B-AWARD M.A O was O supported O by O the O International O Postgraduate O Research O Scholarship O IPRS O and O the O Research O Training O Program O Fee O offset O scholarship O funded O by O the O Australian O Government O and O awarded O by O the O University O of O Melbourne O and O in O part O by O the O Diagnosis O and O Development O group O of O the O Murdoch O Children’s O Research O Institute O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81160248 B-AWARD 81360313 I-AWARD 81560464 O to O Daya O Luo O and O Zhuoqi O Liu O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Province I-ORG No. O 20151BAB205058 B-AWARD 20171BAB205055 O to O Daya O Luo O and O Zhuoqi O Liu O Innovation B-ORG Foundation I-ORG for I-ORG Graduate I-ORG Students I-ORG of I-ORG Nanchang I-ORG University I-ORG No. O CX2015181 B-AWARD to O Yunlei O Song O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O CNPq/MCT B-ORG grant O project-555516/2006-7 O project-575573/2008-2 B-AWARD and O CAPES B-ORG Finance O Code I-AWARD 001 O FADQ O was O granted O a O fellowship O for O research O productivity O from O the O Brazilian B-ORG National I-ORG Council I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Development I-ORG CNPq O process O number O 312656/2019-0 B-AWARD This O work O was O supported O by O grants O from O the O Guangdong B-ORG Modern I-ORG Agricultural I-ORG Industrial I-ORG Technology I-ORG System I-ORG Innovation I-ORG Team I-ORG Project I-ORG grant O number O 2022KJ142 B-AWARD Special B-ORG Funds I-ORG for I-ORG Economic I-ORG Development I-ORG of I-ORG the I-ORG Marine I-ORG Economy I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG grant O number O GDNRC B-AWARD 2022 I-AWARD 38 O and O the O Undergraduate B-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Training I-ORG Program I-ORG of I-ORG Guangdong I-ORG Pharmaceutical I-ORG University I-ORG 202210573062 O This O work O was O supported O by O Administration B-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG No O 20141061),by B-AWARD Medical B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG B2014165 O and O by O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province O China O 20140212 O The O MoveIT O was O supported O by O ZonMW B-ORG project O number O 60-82600-98-8338 B-AWARD Roomsch B-ORG Catholijk I-ORG Oude I-ORG Armen I-ORG Kantoor I-ORG project O number O 2010.101 B-AWARD and O the O “Innovation O Fund” O of O the O Sint B-ORG Lucas I-ORG Andreas I-ORG Hospital I-ORG 2010 I-ORG Motives O MoveIT I-AWARD 2010 O This O study O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0500100 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31702278 O 31672574 O the O Jiangsu B-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Fund I-ORG CX(15)1056 O the O Postdoctoral B-ORG Fund I-ORG of I-ORG Jiangsu I-ORG Province I-ORG 1501030C O and O the O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31601406 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG of I-ORG China I-ORG No. O ZR2016CB30 B-AWARD and O the O Applied B-ORG Basic I-ORG Research I-ORG Project I-ORG of I-ORG Qingdao I-ORG of I-ORG China I-ORG No. O 16-5-1-16-jch B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO. O 81672918 B-AWARD the O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG NO. O 2018A030310154 B-AWARD and O the O Medical B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG NO. O A2017532 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O no. O 81401124 B-AWARD the B-ORG Humanistic I-ORG Nursing I-ORG Care I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O no. O RW2016AM14 B-AWARD Preventive B-ORG Medicine I-ORG Projects I-ORG from I-ORG Bureau I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Y2012083 O “Top B-ORG Six I-ORG Types I-ORG of I-ORG Talents” I-ORG Financial I-ORG Assistance I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grant O no. O 10.WSN016 B-AWARD Jiangsu B-ORG Provincial I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Foundation I-ORG Grant O no. O Z201622 B-AWARD Science B-ORG Foundation I-ORG of I-ORG Nantong I-ORG City I-ORG Grant O no. O MS22015003 B-AWARD the B-ORG College I-ORG graduate I-ORG research I-ORG and I-ORG innovation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG KYZZ15_0353 O and O the B-ORG Nantong I-ORG University I-ORG Graduate I-ORG Innovation I-ORG Program I-ORG YKC15075 O This O study O was O supported O by O the O Medical B-ORG Research I-ORG Council I-ORG MR/M023672/1 O Wellcome B-ORG 091593/Z/10/Z O and O 205103/Z/16/Z B-AWARD and O the B-ORG Stroke I-ORG Association I-ORG TSA O PDF I-AWARD 2017/02 O TSA B-AWARD 2014/02 O The O design O of O this O study O writing O the O manuscript O and O data O collection O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O No. O 31860274 B-AWARD YNCUB B-ORG No. O 2017KF009 B-AWARD The O collection O analysis O and O interpretation O of O data O was O supported O by O Yunnan B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG Nos O 2017FE468(-155 B-AWARD CXTD201703 B-AWARD 2017IB011 B-AWARD This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China(No.81870193 O Jiangsu B-ORG Provincial I-ORG Special I-ORG Program I-ORG of I-ORG Medical I-ORG Science(BE2017610 O The B-ORG Young I-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81700415 O The B-ORG Project I-ORG of I-ORG Invigorating I-ORG Health I-ORG Care I-ORG through I-ORG Science I-ORG Technology I-ORG and I-ORG Education I-ORG Jiangsu I-ORG Provincial I-ORG Medical I-ORG Youth I-ORG Talent I-ORG This O manuscript O is O based O on O RETAPP O trial O which O is O jointly O funded O by O the O MRC-Wellcome-DFID O through O theJoint O Global I-ORG Health I-ORG Trials O grant O number O MR/L004283/1 B-AWARD and O theBill O I-ORG Melinda I-ORG Gates I-ORG Foundation[grant O number O OPP1158281 B-AWARD Fyezah O Jehan O and O Imran O Nisar O received O funding O from O theNational O Institute I-ORG of I-ORG Health’s I-ORG Fogarty I-ORG International I-ORG Centre[Grant O Number O 1 B-AWARD D43 I-AWARD TW007585-01 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O No. O 81770621 B-AWARD Ministry B-ORG of I-ORG Education I-ORG Culture I-ORG Sports I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Japan I-ORG KAKENHI O No. O 18H02866 B-AWARD and O Japan O Science O and O Technology O Agency-Japan O International O Cooperation O Agency’s O JST-JICA O Science B-ORG and I-ORG Technology I-ORG Research I-ORG Partnership I-ORG for I-ORG Sustainable I-ORG Development I-ORG SATREPS O Project O No. O JPMJSA1506 B-AWARD The O project O was O funded O by O CINVESTAV-IPN B-ORG México I-ORG M.E.H.-L O was O the O recipient O of O Award O Number O CN-7254 B-AWARD M.G.-A O was O the O recipient O of O a O doctoral B-ORG fellowship I-ORG Award O number O 233424 B-AWARD and O two O postdoctoral O projects O 857785 O and O 2528992 B-AWARD from O Consejo B-ORG Nacional I-ORG de I-ORG Ciencia I-ORG y I-ORG Tecnología I-ORG CONACYT O México O This O work O was O supported O by O The B-ORG Scientific I-ORG Innovation I-ORG Team I-ORG Project I-ORG of I-ORG Ningbo I-ORG Grant O No. O 2013B82010 B-AWARD Ningbo B-ORG Health I-ORG Branding I-ORG Subject I-ORG Fund I-ORG PPXK2018-03 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Ningbo I-ORG Grant O No. O 2017A610152 B-AWARD This O work O was O supported O by O the O Slovak B-ORG Research I-ORG and I-ORG Development I-ORG Agency I-ORG under O the O contract O No. O APVV-18-0188 B-AWARD and O by O the O Slovak B-ORG Grant I-ORG Agency I-ORG for I-ORG Science I-ORG VEGA I-ORG grant O number O 2/0111/22 B-AWARD This O publication O is O the O result O of O the O project O CEMBAM O Centre O for O Medical O Bio-Additive O Manufacturing O and O Research O ITMS2014 B-AWARD 313011V358 O supported O by O the O Operational O Programme O Integrated O Infrastructure O funded O by O the O European B-ORG Regional I-ORG Development I-ORG Fund I-ORG This O work O was O supported O by O the O Starting B-ORG growth I-ORG Technological I-ORG R&D I-ORG Program I-ORG TIPS O Program O No. O S3130592 B-AWARD funded O by O the O Ministry O of O SMEs O and O Startups O MSS O Korea O in O 2021 O J.-H.J O was O supported O by O a O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O grant O MSIT O 2020R1A5A2031185 O and O Chonnam B-ORG National I-ORG University I-ORG grant O No. O 2019-0232 B-AWARD M.S O was O supported O by O a O NRF-2022M3E5F1018375 B-AWARD and O the O Hankuk B-ORG University I-ORG of I-ORG Foreign I-ORG Studies I-ORG Research I-ORG Fund I-ORG of O 2023 O D.L O was O supported O by O a O 2022 O Research O Grant O from O Kangwon B-ORG National I-ORG University I-ORG and I-ORG a I-ORG National I-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG grant O funded O by O the O Korean O government O MSIP O NRF-2022R1F1A1063564 O This O work O was O financially O supported O by O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-34 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31860681 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Inner I-ORG Mongolia I-ORG 2017MS0317 O The O funding O bodies O had O no O roles O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81902745 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG 2018JJ3716 O and O Central B-ORG South I-ORG University I-ORG Innovative I-ORG Program I-ORG for I-ORG Undergraduates I-ORG No. O 20190034020002 B-AWARD The O funding O parties O had O no O role O in O the O study O design O data O collection O and O analysis O and O interpretation O of O data O or O in O the O manuscript O writing O The O Atherosclerosis O Risk O in O Communities O ARIC O Study O was O carried O out O as O a O collaborative O study O supported O by O National B-ORG Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute I-ORG contracts O HHSN268201100005C B-AWARD HHSN268201100006C B-AWARD HHSN268201100007C B-AWARD HHSN268201100008C B-AWARD HHSN268201100009C B-AWARD HHSN268201100010C B-AWARD HHSN268201100011C B-AWARD and O HHSN268201100012C B-AWARD Funding O for O the O ARIC O Gene O Environment O Association O Studies O dbGaP O Study O Accession O phs000090.v2.p1 O a O sub-study O of O phs000280.v2.p1 O was O provided O by O National B-ORG Human I-ORG Genome I-ORG Research I-ORG Institute I-ORG grant O U01HG004402 B-AWARD Eric O Boerwinkle O Support O for O the O Howard O University O Family O Study O was O provided O by O National B-ORG Institutes I-ORG of I-ORG Health I-ORG grants O S06GM008016-320107 B-AWARD S06GM008016-380111 B-AWARD and O 2M01RR010284 B-AWARD Genotyping O support O was O provided O by O the O Coriell O Institute O for O Medical O Research O This O research O was O supported O by O the O Intramural O Research O Program O of O the O Center O for O Research O on O Genomics O and O Global O Health O CRGGH O The O CRGGH O is O supported O by O the O National O Human O Genome O Research O Institute O the O National O Institute O of O Diabetes O and O Digestive O and O Kidney O Diseases O the O Center O for O Information O Technology O and O the O Office O of O the O Director O at O the O National O Institutes O of O Health O Z01HG200362 O This O work O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81361120245 O 31201011 B-AWARD 81261120570 B-AWARD 91232302 B-AWARD 81428009 B-AWARD MOST B-ORG International I-ORG Collaboration I-ORG Grant I-ORG 2011DFG33250 O and O Program B-ORG for I-ORG Changjiang I-ORG Scholars I-ORG and I-ORG Innovative I-ORG Research I-ORG Team I-ORG in I-ORG University I-ORG IRT13016 O The O research O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O 81701708 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O China O under O Grant O 2017A030310205 B-AWARD Training B-ORG Project I-ORG for I-ORG Young I-ORG Teacher I-ORG of I-ORG Sun I-ORG Yat-sen I-ORG University I-ORG under O Grant O 18ykpy10 B-AWARD The O funding O body O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O We O thank O the O John B-ORG Templeton I-ORG Foundation I-ORG grant O no. O 23807 B-AWARD and O the O Economic B-ORG and I-ORG Social I-ORG Research I-ORG Council I-ORG ESRC O for O funding O the O November O 2014 O workshop O that O brought O several O of O the O issue O contributors O together O This O work O was O supported O in O part O by O Natural B-ORG Sciences I-ORG and I-ORG Engineering I-ORG Research I-ORG Council I-ORG of I-ORG Canada I-ORG NSERC O grants O to O S.M.R O nos O 418342-2012 B-AWARD and O 429385-2012 B-AWARD and O J.M.-F O no. O 435596-2013 B-AWARD and O an O ESRC O grant O awarded O to O E.F O ES/J021385/1 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Projects O No. O 31670692 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG Projects O No. O LY18C160004 B-AWARD and O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG Projects O No. O 2017YFD04008 B-AWARD This O project O was O conducted O as O part O of O a O visiting O scholar O research O program O The O first O author O was O financially O supported O by O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDA19030404 O the O Youth B-ORG Innovation I-ORG Promotion I-ORG Association I-ORG CAS I-ORG 2017089 O the O China B-ORG Scholarship I-ORG Council I-ORG 201504910261 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41301390 O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG 2014AA06A511 O and O the O Major B-ORG State I-ORG Basic I-ORG Research I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2013CB733405 O and O 2010CB950603 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81371397 B-AWARD Xiamen B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG Fund I-ORG Project I-ORG Grant O No.3502Z20144016 O and O Fujian B-ORG Youth I-ORG Fund I-ORG Project I-ORG Grant O No.2015-2-50 O This O work O was O supported O in O part O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG under O Grant O 2018YFB0905702 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O 61974016 B-AWARD and O the O Science B-ORG Challenge I-ORG Project I-ORG under O Grant O TZ2018003 B-AWARD This O study O is O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81572481 B-AWARD 81272197 B-AWARD to O Ying O Peng O International B-ORG Collaboration I-ORG Program I-ORG of I-ORG Universities I-ORG in I-ORG Guangdong I-ORG Province I-ORG No.2012gjhz001 O and O the B-ORG Key I-ORG Project I-ORG of I-ORG Product I-ORG Study I-ORG and I-ORG Research I-ORG of I-ORG Guangzhou I-ORG city I-ORG No. O 201508020058 B-AWARD to O Ying O Peng O Grant O KLB09001 B-AWARD from O the B-ORG Key I-ORG Laboratory I-ORG of I-ORG Malignant I-ORG Tumor I-ORG Gene I-ORG Regulation I-ORG and I-ORG Target I-ORG Therapy I-ORG of I-ORG Guangdong I-ORG Higher I-ORG Education I-ORG Institutes I-ORG Sun I-ORG Yat-Sen I-ORG University I-ORG and O Grant O 2013]163 B-AWARD from O Key B-ORG Laboratory I-ORG of I-ORG Malignant I-ORG Tumor I-ORG Molecular I-ORG Mechanism I-ORG and I-ORG Translational I-ORG Medicine I-ORG of I-ORG Guangzhou I-ORG Bureau I-ORG of I-ORG Science I-ORG and I-ORG Information I-ORG Technology O National O Natural O Science O Foundation O of O China O No. O 81502167 B-AWARD and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2015A030313030 B-AWARD to O Xiaoming O Rong O Work O in O the O laboratory O of O H.A.R O is O or O was O supported O by O NIH/NIDDK B-ORG grants O R01DK12044 B-AWARD R01DK132387 B-AWARD a O new O investigator O award O from O NIDDK/HIRN B-ORG RRID O SCR_014393 B-AWARD UC24 B-AWARD DK104162 O the B-ORG Culshaw I-ORG Junior I-ORG Investigator I-ORG Award I-ORG in I-ORG Diabetes O the O JDRF O the O Children’s O Diabetes O Foundation O and O the O Gate’s O Grubstake O Fund O A.H.S O was O supported O by O pre-doctoral B-ORG training I-ORG grants I-ORG in I-ORG Stem I-ORG Cell I-ORG Biology-5T32AR007411-35 O and O Interdisciplinary B-ORG Bioengineering I-ORG Research I-ORG Training I-ORG in I-ORG Diabetes—T32 O DK I-AWARD 120520 I-AWARD This O work O was O supported O in O part O by O the O Major B-ORG Scientific I-ORG and I-ORG Technological I-ORG Special I-ORG Projects I-ORG in I-ORG Jilin I-ORG Province I-ORG and I-ORG Changchun I-ORG City I-ORG 20220301008GX O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 52072333 O 52202503 B-AWARD the O Hebei B-ORG Natural I-ORG Science I-ORG Foundation I-ORG F2022203054 O the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Hebei I-ORG Education I-ORG Department I-ORG BJK2023026 O This O work O was O partly O supported O by O the B-ORG Grant-in-Aid I-ORG for I-ORG Scientific I-ORG Research I-ORG B) O Grant O Nos O 17H03398 B-AWARD 20H01841 B-AWARD 22H02161 B-AWARD and O the B-ORG Grants-in-Aid I-ORG for I-ORG Transformative I-ORG Research I-ORG Area I-ORG A) I-ORG ’Hyper-Ordered I-ORG Structures I-ORG Science’ I-ORG Grant O Nos O 20H05878 B-AWARD 20H05881 B-AWARD 20H5882 B-AWARD 20H05884 B-AWARD from O the O Ministry O of O Education O Culture O Sports O Science O and O Technology O of O Japan O and O was O partly O based O on O collaborative O research O between O Sumitomo O Metal O Mining O Co O Ltd O and O Tohoku O University O which O is O part O of O the O Vision O Co-creation O Partnership O The O synchrotron O radiation O experiments O were O performed O with O the O approval O of O Japan B-ORG Synchrotron I-ORG Radiation I-ORG Research I-ORG Institute I-ORG JASRI O Proposal O No. O 2021A1018 B-AWARD This O study O was O financially O supported O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0200200 O and O 2017YFD0200202 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC I-ORG 31330070 O and O 31210103906 B-AWARD the O Innovative B-ORG Group I-ORG Grant I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31421092 O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG 973-2015CB150405 O We O are O grateful O to O the O financial O support O from O three O fund O projects O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0501103 O supported O the O design O of O study O and O data O collection O and O writing O the O manuscript O Key B-ORG Scientific I-ORG and I-ORG Technological I-ORG Research I-ORG Projects I-ORG in I-ORG Henan I-ORG Province I-ORG 182102110087 O and O Scientific B-ORG and I-ORG Technological I-ORG Projects I-ORG for I-ORG Overseas I-ORG Students I-ORG 22991803 O supported O analysis O interpretation O of O data O This O work O was O financially O supported O by O the O Zhejiang B-ORG Provincial I-ORG Postdoctoral I-ORG Research I-ORG Program I-ORG No. O 219756 B-AWARD the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Projects I-ORG of I-ORG Zhejiang I-ORG Province I-ORG in O 2018 O No. O 2018C02034 B-AWARD and O Zhejiang B-ORG Province I-ORG Agricultural I-ORG Chinese I-ORG Medicine I-ORG New I-ORG Variety I-ORG Breeding I-ORG Major I-ORG Science I-ORG and I-ORG Technology I-ORG Special I-ORG Project I-ORG No. O 2016C02058-3 B-AWARD This O article O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2019YFC1709003 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81870224 B-AWARD 82105000 B-AWARD 81904306 B-AWARD and O Post-doctoral B-ORG Research I-ORG and I-ORG Development I-ORG Fund I-ORG of I-ORG West I-ORG China I-ORG Hospital O Sichuan O University O No.2020HXBH049 O This O research O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG Municipal O No. O 20ZR1424100 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 21775102 B-AWARD and O the O Key B-ORG Laboratory I-ORG of I-ORG Bioanalysis I-ORG and I-ORG Metrology I-ORG for I-ORG State I-ORG Market I-ORG Regulation I-ORG No. O KLSMR2022-01 B-AWARD This O research O was O supported O by O NSF B-AWARD DEB I-AWARD 1257701 I-AWARD Collaborative O Research O Award O to O CDS B-ORG and I-ORG SYS O and O NSF B-AWARD DEB I-AWARD 0816661 I-AWARD Research O Opportunity O Award O Supplement O to O CDS B-ORG and I-ORG CFB O This O work O used O the O Vincent O J. O Coates O Genomics O Sequencing O Laboratory O at O UC O Berkeley O supported O by O NIH B-ORG S10 I-ORG Instrumentation O Grants O S10RR029668 B-AWARD and I-AWARD S10RR027303 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Deanship B-ORG of I-ORG Scientific I-ORG Research I-ORG Vice I-ORG Presidency I-ORG for I-ORG Graduate I-ORG Studies I-ORG and I-ORG Scientific I-ORG Research I-ORG King I-ORG Faisal I-ORG University I-ORG Saudi I-ORG Arabia I-ORG Grant O No.2647 O through O its O KFU O Research O Summer O initiative O The O researchers O are O supported O by O a O full O Ph.D O scholarship O under O the O joint B-ORG executive I-ORG program I-ORG between I-ORG the I-ORG Arab I-ORG Republic I-ORG of I-ORG Egypt I-ORG and I-ORG Saint I-ORG Petersburg I-ORG State I-ORG University I-ORG for O the O fourth O author O M.I.S O number O EGY-0026/20 B-AWARD and O Kazan B-ORG federal I-ORG University I-ORG for O the O third O author O Egy.6572/19 B-AWARD M.Y.H O This O study O was O supported O in O part O by O grants O from O Deutsche B-ORG Forschungsgemeinschaft I-ORG MO O 1421/2-1 I-AWARD and O MO B-AWARD 1421/5-1 O and O Deutsche B-ORG Krebshilfe I-ORG 612000 O to O HM, O and O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81761138047 O to O HJ. O This O study O was O partly O supported O by O Capital B-ORG Health I-ORG Development I-ORG Fund I-ORG 201614035 O and O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG 2016-I2M-1-011 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2018-F05 O and O Youth B-ORG Research I-ORG Fund I-ORG of I-ORG Peking I-ORG Union I-ORG Medical I-ORG College I-ORG 2018-XHQN03 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21927811 O 21575082 B-AWARD 22076105 B-AWARD 91753111 B-AWARD and O 21976110 B-AWARD and O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG 2018YFJH0502 O Development B-ORG plan I-ORG of I-ORG science I-ORG and I-ORG technology I-ORG for I-ORG Shandong I-ORG Province I-ORG of I-ORG China I-ORG 2013GGX10706 O and O A B-ORG Project I-ORG of I-ORG Shandong I-ORG Province I-ORG Higher I-ORG Educational I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG J13LD06 O National B-ORG Science I-ORG Foundation O USA O 1127112 O with O in-kind O infrastructure O and O intellectual O support O from O the O National O Institute O of O Health-funded O Reactome O database O project O of O Reactome O P41 O HG003751 I-AWARD and O 1U54GM114833-01 B-AWARD CFREF O Medicine O by O Design O and O the O European O Molecular O Biology O Laboratory O National O Science O Foundation O USA O supported O Planteome O Project O 1340112 O provided O InParanoid O gene O homology O dataset O Unites O States O Department O of O Agriculture O National B-ORG Institute I-ORG of I-ORG Food I-ORG and I-ORG Agriculture I-ORG award O 2019-67032-29072 O Ag-REEU O Undergraduate O Learning O Experiences O in O working O with O Big O Data O in O Agriculture O supported O DAD O for O an O eight O week O summer O program O The O PubChem O integration O was O supported O in O part O by O the O Intramural O Research O Program O of O the O National O Library O of O Medicine O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH O Powered-by-CyVerse O support O for O the O Plant O Reactome O mirror O site O is O funded O by O the O National O Science O Foundation O USA O 1743442 O Funders O had O no O role O in O the O study O design O data O analysis O or O preparation O of O the O manuscript O Funding O for O open O access O charge O National O Science O Foundation O USA O 1127112 O This O research O was O funded O by, O the O National O Key O R&D O Plan O 2016YFA0202200 O the O Natural O Science O Foundation O of O Inner O Mongolia O 2017MS0116),the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61504092 O the O Tianjin B-ORG Research I-ORG Program I-ORG of I-ORG Application I-ORG Foundation I-ORG and I-ORG Advanced I-ORG Technology I-ORG 15JCQNJC01200 O the O National B-ORG 973 I-ORG Program I-ORG of I-ORG China I-ORG 61331901 O the O AoShan O Talents O outstanding O scientist O program O supported O by O pilot O Qingdao O National O Laboratory O for O Marine O Science O and O Technology O 2017ASTCP-OS03 O and O the O Qingdao O National O Laboratory O for O Marine O Science O and O Technology O QNLM2016ORP0411 O This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U22A20506 O 32072720 B-AWARD the O Key B-ORG Research I-ORG and I-ORG Talent I-ORG Introduction I-ORG Project I-ORG of I-ORG Ningxia I-ORG Hui I-ORG Autonomous I-ORG Region I-ORG 2021BEF01002 O 2021NXZD1 B-AWARD and O the O cultivation B-ORG project I-ORG for I-ORG talents I-ORG in I-ORG science I-ORG and I-ORG technology I-ORG innovation I-ORG of I-ORG Ningxia I-ORG Hui I-ORG Autonomous I-ORG Region I-ORG 2020GKLRLX02 O The O funding O bodies O played O no O role O in O the O design O of O the O study O collection O analysis O and O interpretation O of O data O and O writing O the O manuscript O This O project O was O funded O by O the O Deutsche B-ORG Forschungsgesellschaft I-ORG to O K.S O and O N.M O German O Research O Foundation O TRR B-AWARD 219 O Project-ID B-AWARD 322900939 I-AWARD C-07 I-AWARD M03 I-AWARD M05 O LURIC O was O supported O by O the O HORIZON2020 B-ORG Programs I-ORG TO_AITION I-ORG grant O agreement O number O 848146 B-AWARD and O TIMELY O grant O agreement O number O 101017424 B-AWARD of O the O European B-ORG Union I-ORG This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 21432003 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Gansu I-ORG No. O 18JR3RA280 O and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O lzujbky-2017-148 O This O research O was O funded O by O National O Key O R O O D O Plan O of O the O “13th O Five-Year” O 2017YFD0601105 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51706207 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG LQ19E060009 O the B-ORG Young I-ORG Elite I-ORG Scientists I-ORG Sponsorship I-ORG Program I-ORG by I-ORG CAST I-ORG 2018QNRC001 O the O Fund O of O Zhejiang O Provincial O Collaborative O Innovation O Center O for O Bamboo O Resources O and O High-Efficiency O Utilization O 2017ZZY2-02 O Undergraduate O Research O Training O Program O of O Zhejiang O A O O F O University O KX20180111 O and O National O Undergraduate O Innovation O and O Entrepreneurship O Training O Program O This O work O was O financially O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG Project O No O LY19A020004 B-AWARD LY19E010005 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Project O No O 11602221 B-AWARD 11472246 O the O General B-ORG Research I-ORG Projects I-ORG of I-ORG Zhejiang I-ORG Provincial I-ORG Department I-ORG of O Education O Project O No O Y201840296 B-AWARD and O the O Cultivation O Project O of O Zhejiang O Ocean O University O Project O No O 2015A13 B-AWARD The O work O was O supported O by O Discipline B-ORG Leading I-ORG Talent I-ORG Plan I-ORG of I-ORG Anhui I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG LJRC-202107 O the O earmarked O fund O for O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG of I-ORG MOF I-ORG and I-ORG MARA I-ORG CARS-43-A-4 O the O Provincial B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG Anhui I-ORG Province I-ORG 202104a06020032 O Anhui B-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Livestock I-ORG and I-ORG Poultry I-ORG Product I-ORG Safety I-ORG Engineering I-ORG Project I-ORG No. O XMT2022-8 B-AWARD We O would O like O to O thank O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 21503146 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Tianjin I-ORG Municipality I-ORG 18JCYBJC21200 O and O Yangtze B-ORG Scholars I-ORG and I-ORG Innovative I-ORG Research I-ORG Team I-ORG in I-ORG Chinese I-ORG University I-ORG IRT-17R81 O in O supporting O the O work O This O research O was O funded O by O the O National O Key O R&D O Program O of O China O grant O number O 2018YFB1600-100 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG grant O number2019JJ40297 O the B-ORG education I-ORG department I-ORG of I-ORG Hunan I-ORG Province I-ORG grant O number O 18B143 B-AWARD 18B144 O Science O and O Technology O progress O and O Innovation O Project O of O Hunan O Provincial O Department O of O Transportation O grant O number O 201904 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 51608055 O 51608058 B-AWARD Open O Found O of O Key O Laboratory O of O Special O Environment O Road O Engineering O of O Hunan O Province O Changsha O University O of O Science O and O Technology O grant O number O Kfj190501 O State O Scholarship O Fund O grant O number O 201908430034 O the O project O of O Changsha O science O and O Technology O Bureau O grant O number O kq1901107 O This O project O was O financially O supported O by O the B-ORG Modern I-ORG Agricultural I-ORG Industry I-ORG Technology I-ORG System I-ORG CARS-36 O Developing B-ORG key I-ORG equipment I-ORG for I-ORG digital I-ORG management I-ORG and I-ORG monitoring I-ORG environment I-ORG in I-ORG animal I-ORG production I-ORG 2013AA10230602 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31372317 O and O the B-ORG 111 I-ORG Project I-ORG B16044 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Program I-ORG 7184210 O S160001 B-AWARD National B-ORG key I-ORG research I-ORG and I-ORG development I-ORG program I-ORG 2016YFC1000304 O and O ‘Capital B-ORG Clinical I-ORG Characteristic I-ORG Research’ I-ORG from I-ORG Beijing I-ORG Science I-ORG Committee I-ORG Grant O Number O Z161100000516160 B-AWARD This O work O was O supported O by O Ningbo B-ORG Science I-ORG I-ORG Technology I-ORG Bureau I-ORG No. O 2019A610391 B-AWARD the B-ORG Medical I-ORG Technology I-ORG Program I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG China I-ORG No. O 2018KY730 B-AWARD No.2018KY680 O and O the O Project O of O Zhejiang B-ORG Public I-ORG Welfare I-ORG Fund I-ORG No. O LGF19H260010 B-AWARD The O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21575058 O 81271931 B-AWARD 81802435 B-AWARD Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG 201604020104 O 201803040009 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2018A030313286 O 2019B020208009 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG funded O project O 2019T120742 O 2016M602486 B-AWARD This O study O was O partially O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31490591 O 31330032 B-AWARD and O 61327902 B-AWARD the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFA0700500 O the O Frontier B-ORG Key I-ORG Project I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG QYZDJ-SSW-SMC025 O Shanghai B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Major O Project O 2018SHZDZX05 O This O work O was O supported O by O grants O from O the O Chung B-ORG Shan I-ORG Medical I-ORG University I-ORG Hospital I-ORG grant O number O CSH-2022-D-004 B-AWARD Chung B-ORG Shan I-ORG Medical I-ORG University I-ORG and I-ORG Changhua I-ORG Christian I-ORG Hospital I-ORG grant O number O CSMU-CCH-111-10 B-AWARD China B-ORG Medical I-ORG University I-ORG grant O number O CMU111-MF-68 B-AWARD and O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG grant O number O MOST O 109-2314-B-040-007 B-AWARD in O Taiwan O This O study O was O supported O by O Grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 81602498 B-AWARD 31501120 B-AWARD and O 81571250 B-AWARD the B-ORG Joint I-ORG Funds I-ORG for I-ORG the I-ORG Innovation I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Fujian I-ORG Province I-ORG Grant O No. O 2016Y9040 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG Grant O Nos O 2018J06007 B-AWARD 2018J01830 B-AWARD and O 2018J01838 B-AWARD the B-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG Fujian I-ORG Province I-ORG Grant O Nos O 2016-ZQN-65 B-AWARD and O 2016-1-39 B-AWARD the B-ORG Outstanding I-ORG Youth I-ORG Scientific I-ORG Research I-ORG Personnel I-ORG Training I-ORG Programme I-ORG in I-ORG Fujian I-ORG Province I-ORG University I-ORG Grant O No. O 2016B023 B-AWARD This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51704179 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2019BEE018 O ZR2016EEB23 O Scientific O Research O Foundation O of O Shandong O University O of O Science O and O Technology O for O Recruited O Talents O 2017RCJJ002 O and O the B-ORG First-class I-ORG discipline I-ORG construction I-ORG projects I-ORG 01AQ03703 O 01CK05902 O And O The O APC O was O funded O by O National O Natural O Science O Foundation O of O China O 51704179 O Natural O Science O Foundation O of O Shandong O Province O ZR2016EEB23 O This O work O was O supported O by O the O U.S O National B-ORG Institute I-ORG on I-ORG Aging I-ORG P01AG041710 O 1R01AG051144–01 B-AWARD 3U54HG006938-03S1 B-AWARD and O the O support O for O the O Agincourt O Health O and O socio-Demographic O Surveillance O System O by O the O University O of O the O Witwatersrand O and O Medical O Research O Council O South O Africa O and O the O Wellcome B-ORG Trust O UK O grants O 058893/Z/99/A O 069683/Z/02/Z B-AWARD 085477/B/08/Z B-AWARD ANW O is O supported O by O the O Fogarty B-ORG International I-ORG Center I-ORG of O the O National O Institutes O of O Health O under O Award O Number O K43TW010698 B-AWARD The O funding O sponsors O had O no O role O in O the O design O of O the O study O or O collection O analysis O and O interpretation O of O data O or O writing O of O the O manuscript O This O work O was O supported O by O the O Foundation B-ORG of I-ORG Hubei I-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG Grant O No. O 2016BKJ005 B-AWARD the O Leading O Plan O of O Green O Industry O of O Hubei O University O of O Technology O Grant O No. O YXQN2016003 B-AWARD the O International B-ORG Science I-ORG and I-ORG Technology I-ORG Cooperation I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2016YFE0124300 B-AWARD the O Open O Foundation O of O Hubei O Key O Laboratory O for O High-efficiency O Use O of O Solar O Energy O and O Operation O Control O of O Energy O Storage O System O Grant O Nos O HBSEES201801 B-AWARD HBSEES201705 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 51602099 B-AWARD 51371079 I-AWARD 11304092 I-AWARD and I-AWARD 11305056 O 1) O Project B-ORG of I-ORG Taizhou I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG in I-ORG 2018 I-ORG No O 1801ky50 B-AWARD 2) O 2017 B-ORG Zhejiang I-ORG Medical I-ORG Association I-ORG Project I-ORG No O 2017zyc-a118 B-AWARD 3) O 2013 B-ORG Provincial I-ORG Medical I-ORG Association I-ORG Project I-ORG No O 2013zyc-a138 B-AWARD 4) O 2013 B-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG of I-ORG Jiaojiang I-ORG District I-ORG No O 132055 B-AWARD The O design O of O this O study O which O involved O prior O investigation O was O supported O by O Shanghai B-ORG Excellent I-ORG Young I-ORG Talents I-ORG Project I-ORG in I-ORG Health I-ORG Systems O 2018YQ52 O Data O extraction O was O financially O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 71603182 O 71774116 B-AWARD The O analysis O and O interpretation O of O the O data O under O the O guidance O of O statisticians O was O supported O by O grants O from O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC1314700 O The O paper’s O writing O and O revision O including O language O improvement O were O sponsored O by O the O Shanghai B-ORG Pujiang I-ORG Program I-ORG 2019PJC072 O Soft B-ORG Project I-ORG of I-ORG Coronavirus I-ORG Prevention I-ORG and I-ORG Control I-ORG 2020RK38 O and O Medicine O and O Engineering O Interdisciplinary O Research O Fund O of O Shanghai O Jiao O Tong O University O YG2020YQ06 O This O work O was O supported O by O the O following O grants O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo I-ORG FAPESP—C.S.H.—grant O number O 2019/24639-7 B-AWARD the O Medical B-ORG Research I-ORG Council I-ORG grant O number O MR/S008608/1 B-AWARD and O the O Academy B-ORG of I-ORG Medical I-ORG Sciences I-ORG grant O number O SBF004\1112 B-AWARD The O RV254 O study O was O supported O in O part O by O a O cooperative O agreement O W81XWH-11-2-0174 O and O W81XWH-18-2-0040 B-AWARD between O the O Henry B-ORG M. I-ORG Jackson I-ORG Foundation I-ORG for O the O Advancement O of O Military O Medicine O Inc O and O the O U.S O Department O of O Defense O DoD O Material O has O been O reviewed O by O the O Walter O Reed O Army O Institute O of O Research O JA O and O SS O were O partially O supported O by O National O Institute I-ORG of I-ORG Mental I-ORG Health I-ORG and O National B-ORG Institute I-ORG of I-ORG Neurological I-ORG Disorders I-ORG and I-ORG Stroke O R01MH095613 B-AWARD and O R01NS084911 B-AWARD This O work O was O supported O by O China B-ORG Apple I-ORG Research I-ORG System I-ORG CARS-27 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31672101 O Shaanxi B-ORG key I-ORG research I-ORG and I-ORG development I-ORG plan I-ORG 2017ZDXM-NY-019 O Yangling O Subsidiary O Center O Project O of O the O National O Apple O Improvement O Center O and O Collaborative O Innovation O of O the O Center O for O Shaanxi O Fruit O Industry O Development O This O work O was O supported O by O funds O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81360346,http://www.nsfc.gov.cn B-AWARD The O Social B-ORG Developmental I-ORG Research I-ORG Foundation I-ORG of I-ORG Guizhou I-ORG Province I-ORG grant O number O SY(2012)3094,http://www.gzpopss.gov.cn B-AWARD and O Guizhou B-ORG Province's I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG Qian-J-Zhong I-ORG grant O number O 2015]2003,http://kjzdzx.gzste.org B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O byColciencias(grant O number O 727 B-AWARD 2015),University O of I-ORG Antioquia(grant O number O 2017-15551 B-AWARD andBiogenesis O Research I-ORG Group(grant O number O ES84180138 B-AWARD from O Colombia O This O work O was O supported O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG 5U41HG007234 O and O 1U01HL137183-01 B-AWARD to O J.S O A.N O and O B.P O the O Wellcome B-ORG Trust I-ORG WT206194 O to O J.S O E.G O and O R.D O WT207492 B-AWARD to O R.D O and O the O W. B-ORG M. I-ORG Keck I-ORG Foundation I-ORG DT06172015 O to O J.S O A.N O and O B.P O This O research O was O funded O by O Shandong B-ORG Provincial I-ORG Science I-ORG Fund I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG No. O ZR2020JQ11 B-AWARD Young B-ORG Taishan I-ORG Scholars I-ORG No. O TSQN201909159 B-AWARD Youth B-ORG Innovation I-ORG Promotion I-ORG Association I-ORG CAS I-ORG Y2021063 O Key B-ORG Innovation I-ORG Project I-ORG of I-ORG Qilu I-ORG University I-ORG of I-ORG Technology I-ORG Shandong O Academy O of O Sciences O 2022JBZ01-06 O Shandong B-ORG Taishan I-ORG leading I-ORG talent I-ORG project I-ORG No. O LJNY202015 B-AWARD and O the O Central B-ORG Government I-ORG Guides I-ORG Local I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Special I-ORG Fund I-ORG Project I-ORG No. O YDZX2021051 B-AWARD This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2018YFC0311106 O the B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Projects I-ORG of I-ORG Anhui I-ORG province I-ORG 17030701059 O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Department I-ORG of I-ORG Education I-ORG of I-ORG Anhui I-ORG Province I-ORG KJ2017A020 O This O work O was O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD1000300 O Guangdong B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 2016B020202006 O International B-ORG Collaborative I-ORG Project I-ORG from I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG No. O 2013DFB30400 B-AWARD National O Banana O Industry O and O Technology O System O Project O nycytx-33 O Guangdong O Provincial O Special O Fund O For O Modern O Agriculture O Industry O Technology O Innovation O Teams O and O 948 O Project O of O the O Department O of O Agriculture O 2011-G16 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG 2016A030310326 O The O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61802246 B-AWARD and O the O 111 B-ORG Project I-ORG No. O D18003 B-AWARD Zhong O Wang’s O work O was O supported O by O the O U.S B-ORG Department I-ORG of I-ORG Energy I-ORG Office I-ORG of I-ORG Science I-ORG Office I-ORG of I-ORG Biological I-ORG and I-ORG Environmental I-ORG Research I-ORG under O Contract O No. O DE-AC02-05CH11231 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O research O was O supported O by O grants O from O the O National B-ORG Institute I-ORG of I-ORG Environmental I-ORG Health I-ORG Sciences I-ORG NIEHS O P30 B-AWARD ES007033 I-AWARD sponsored-University O of O Washington O UW) O Center O for O Exposures O Diseases O Genomics O and O Environment O EDGE O pilot O grant O to O EH O Ahn O UW B-ORG Office I-ORG of I-ORG Research I-ORG Royalty I-ORG Research I-ORG Fund I-ORG to O EH O Ahn O and O National B-ORG Cancer I-ORG Institute I-ORG NCI O P30 B-AWARD CA015704-39 I-AWARD Fred O Hutchinson O Cancer O Research O Center-UW O Cancer O Consortium O Support O Grant O to O EH O Ahn O NCI O R21 B-AWARD CA220111 I-AWARD to O EH O Ahn O and O NCI O of O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH O under O award O numbers O P01 B-AWARD AG001751 I-AWARD and O R33 B-AWARD CA181771 I-AWARD to O Lawrence O A. O Loeb O The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O NIH O This O research O was O funded O by O the O Amazon B-ORG Foundation I-ORG for I-ORG Research I-ORG Support I-ORG FAPESPA O grant O number O 006/2020 B-AWARD the O Secretary B-ORG of I-ORG Science I-ORG Technology I-ORG and I-ORG Higher I-ORG Professional I-ORG and I-ORG Technological I-ORG Education I-ORG SECTET O grant O number O 09/2021 B-AWARD the O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior—Brazil I-ORG CAPES O grant O number O “Finance O code I-AWARD 001 I-AWARD notice I-AWARD n° I-AWARD 13/2020” O and O the O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico—Brazil O grant O number O “INCT O 406360/2022-7” O JSP O CJQ O ELJ O and O FMY O were O supported O by O the O Center O for O Modeling O Complex O Interactions O sponsored O by O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG https://www.nigms.nih.gov O under O award O number O P20 B-AWARD GM104420 O JSP O and O FMY O were O also O supported O by O National B-ORG Science I-ORG Foundation I-ORG https://www.nsf.gov O EPSCoR O Track-II O under O award O number O OIA1736253 B-AWARD This O study O was O also O supported O by O the O National B-ORG Institutes I-ORG of I-ORG Health O grant O number O P30 B-AWARD GM103324 I-AWARD and O by O the O Office B-ORG of I-ORG Nuclear I-ORG Energy O grant O number O DE-AC07-05ID14517 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O received O funding O from O the O European B-ORG Union I-ORG Horizon I-ORG 2020 I-ORG research I-ORG and I-ORG innovation I-ORG programme I-ORG under I-ORG the I-ORG Marie I-ORG Skłodowska-Curie I-ORG grant I-ORG agreement I-ORG no. O 956257 B-AWARD The O authors O also O acknowledge O the O financial O support O of O Slovenian B-ORG Research I-ORG Agency I-ORG ARRS I-ORG within I-ORG the I-ORG research I-ORG programme I-ORG Horticulture I-ORG P4-0013 O and O within O the O infrastructural B-ORG centre I-ORG IC I-ORG RRG-AG I-ORG IO-0022-0481-0481 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81271315 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG Grant O number O 2016A020215098 B-AWARD and O the O Key B-ORG Project I-ORG of I-ORG Clinical I-ORG Research I-ORG of I-ORG Southern I-ORG Medical I-ORG University I-ORG Grant O number O LC2016ZD024 B-AWARD This O research O was O funded O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2021YFD2200103 O the O Nature B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32071784 O and O the O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O The O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O 81901842 O China B-ORG Primary I-ORG Health I-ORG Care I-ORG Foundation I-ORG YLGX-WS-2020003 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG 2021JJ40936 O This O study O was O supported O by O the O Beijing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG No. O Z171100001017082 B-AWARD the O Special B-ORG Fund I-ORG of I-ORG Capital I-ORG Health I-ORG Research I-ORG and I-ORG Development I-ORG No. O 2016–2-2171 B-AWARD the O Fund B-ORG for I-ORG Beijing I-ORG Science I-ORG I-ORG Technology I-ORG Development I-ORG of I-ORG TCM I-ORG No. O JJ2016-14 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Beijing I-ORG Municipal I-ORG Education I-ORG Commission I-ORG No. O SQKM201610025026 B-AWARD This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 91635303 O to O Y. O W., O 31871626 O to O J. O C O and O 31671703 O to O Z. O Z O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG XDPB0401 O and O XDA08020107 B-AWARD to O Y. O W O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2016YFD0100500 O and O a O Chinese O Thousand O Talents O Program O Grant O to O Y. O W O This O publication O has O emanated O from O research O conducted O with O the O financial O support O of O Science B-ORG Foundation I-ORG Ireland I-ORG SFI O under O grant O number O 12/RC/2289-P2 B-AWARD the O European B-ORG Regional I-ORG Development I-ORG Fund I-ORG under O grant O number O 13/RC/2077-CONNECT B-AWARD and O the O European-funded O project O SAFESENS O under O the O ENIAC O program O in O association O with O Enterprise B-ORG Ireland I-ORG under O grant O number O IR20140024 B-AWARD This O study O was O funded O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFA0105803 O the B-ORG General I-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81770826 O the B-ORG 5010 I-ORG Clinical I-ORG Research I-ORG Projects I-ORG of I-ORG Sun I-ORG Yat-sen I-ORG University I-ORG 2015015 O the B-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Projects I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2016A050502010 O the B-ORG Key I-ORG Special I-ORG Projects I-ORG of I-ORG Medical I-ORG and I-ORG Health I-ORG Collaborative I-ORG Innovation I-ORG of I-ORG Guangzhou I-ORG City I-ORG 201604020016 O the B-ORG Special I-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG Guangzhou I-ORG City I-ORG 2060404 O and O the B-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG of I-ORG Guangzhou I-ORG 201802010048 O This O work O was O supported O by O Grants O from O the B-ORG National I-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2012CB524906 B-AWARD to O X. O Gao O the B-ORG Shanghai I-ORG Municipal I-ORG Health I-ORG Project I-ORG grant I-ORG Grant O No. O 2013ZYJB0802 B-AWARD to O X. O Gao O the B-ORG Shanghai I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG Foundation I-ORG Grant O Nos O 12GWZX0103 B-AWARD and O 2013SY005 B-AWARD to O X. O Gao O and O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG Grant O No. O 13441900303 B-AWARD to O Hua O Bian O This O research O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG grant O number O 2020CFB408 B-AWARD Hubei B-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Green I-ORG Materials I-ORG for I-ORG Light I-ORG Industry I-ORG grant O number O 201710A06 B-AWARD Hubei B-ORG Province I-ORG Key I-ORG Research I-ORG Foundation I-ORG for I-ORG Water I-ORG Resources I-ORG grant O number O HBSLKY2023035 B-AWARD and O the O Open B-ORG Fund I-ORG of I-ORG Hubei I-ORG Longzhong I-ORG Laboratory I-ORG grant O number O 2022ZZ-16 B-AWARD A.D.E O is O partially O supported O by O the O EPSRC B-ORG through I-ORG programme I-ORG grant O no. O UNLOC B-AWARD EP/J017582/1 I-AWARD and O an O advanced O career O fellowship O PEACE O EP/L000091/1 O a O Royal B-ORG Society I-ORG Wolfson I-ORG Research I-ORG Merit I-ORG Award I-ORG WM120035 O and O the O European B-ORG Union I-ORG through I-ORG the I-ORG projects I-ORG FOX-C I-ORG 318415 O and O InSpace O 619732 O N.M.S O is O supported O by O the O European B-ORG Commission I-ORG through I-ORG a I-ORG Marie I-ORG Sklodowska-Curie I-ORG fellowship I-ORG SOLAS I-ORG 608099 O D.S O is O partially O funded O the O Leverhulme O Trust O RPG-2013-48 O and O the O EPSRC O CASE O 12330048 O D.N.P O is O partially O funded O by O the O EPSRC O through O programme O grant O HYPERHIGHWAY O and O the O Centre O for O Innovative O Manufacturing O in O Photonics O This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2019YFA0111900 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81874030 B-AWARD 82072506 B-AWARD 82272611 B-AWARD Provincial B-ORG Clinical I-ORG Medical I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG Hunan I-ORG No. O 2020SK53709 B-AWARD National B-ORG Clinical I-ORG Research I-ORG Center I-ORG for I-ORG Geriatric I-ORG Disorders I-ORG Xiangya O Hospital O No. O 2021KFJJ02 B-AWARD National B-ORG Clinical I-ORG Research I-ORG Center I-ORG for I-ORG Orthopedics I-ORG Sports I-ORG Medicine I-ORG and I-ORG Rehabilitation I-ORG No. O 2021-NCRC-CXJJ-PY-40 B-AWARD Innovation-Driven B-ORG Project I-ORG of I-ORG Central I-ORG South I-ORG University I-ORG No. O 2020CX045 B-AWARD Wu B-ORG Jieping I-ORG Medical I-ORG Foundation I-ORG No. O 320.6750.2020-03-14 B-AWARD CMA B-ORG Young I-ORG and I-ORG Middle-aged I-ORG Doctors I-ORG Outstanding I-ORG Development I-ORG Program-Osteoporosis I-ORG Specialized I-ORG Scientific I-ORG Research I-ORG Fund I-ORG Project I-ORG No. O G-X-2019-1107-12 B-AWARD Key B-ORG Program I-ORG of I-ORG Health I-ORG Commission I-ORG of I-ORG Hunan I-ORG Province I-ORG No. O 20201902 B-AWARD and O Independent B-ORG Exploration I-ORG and I-ORG Innovation I-ORG Project I-ORG for I-ORG Postgraduate I-ORG Students I-ORG of I-ORG Central I-ORG South I-ORG University I-ORG No.2022ZZTS0906 O This O study O was O supported O by O grants O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0500800 O the O China B-ORG Agricultural I-ORG Research I-ORG System I-ORG CARS-42-17 O Integration B-ORG and I-ORG Demonstration I-ORG of I-ORG Key I-ORG Technologies I-ORG for I-ORG Goose I-ORG Industrial I-ORG Chain I-ORG in I-ORG Sichuan I-ORG Province I-ORG 2018NZ0005 O and O the O Sichuan B-ORG Veterinary I-ORG Medicine I-ORG and I-ORG Drug I-ORG Innovation I-ORG Group I-ORG of I-ORG China I-ORG Agricultural I-ORG Research I-ORG System I-ORG CARS-SVDIP O The O funding O body O had O no O role O in O the O design O of O the O study O collection O analysis O and O interpretation O of O data O or O in O the O writing O of O this O manuscript O This O work O was O supported O by O the O Wellcome B-ORG Trust I-ORG grant O numbers O 203147/Z/16/Z B-AWARD and O 205103/Z/16/Z B-AWARD to O CJP O the O Medical B-ORG Research I-ORG Council I-ORG grant O number O MR/M023672/1 B-AWARD to O CJP O and O the O Stroke B-ORG Association I-ORG grant O number O TSA B-AWARD 2014/02 I-AWARD to O CJP O and O DWG O The O work O described O in O this O paper O was O supported O financially O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51979005 O 51809005 O http://www.nsfc.gov.cn O received O by O HZ; O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG China I-ORG E2019402432 O https://kjt.hebei.gov.cn/jjb O received O by O JF; O and O Natural B-ORG Science I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG Shaanxi I-ORG Province I-ORG China I-ORG 2020JM-250 O http://kjt.shaanxi.gov.cn O received O by O HZ. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Special I-ORG Funding I-ORG of I-ORG Doctoral I-ORG Research I-ORG Startup I-ORG Fund I-ORG of I-ORG Guiyang I-ORG College O under O grant O GYU-KY O 2023 O the O Scientific I-ORG Research I-ORG Project I-ORG of I-ORG Higher I-ORG Education I-ORG Institutions I-ORG of I-ORG Guizhou I-ORG Provincial I-ORG Education I-ORG Department I-ORG Youth O Project O under O grant O Qianjiaoji O 2022 I-AWARD 299 O the O Guizhou I-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Basic I-ORG Project O under O grant O QKH-ZK O 2021 I-AWARD JC-141 O the O Guizhou I-ORG Provincial I-ORG Education I-ORG Department O under O grant O KY O 2018 I-AWARD 323 O This O work O was O financially O supported O by O the O Postgraduate B-ORG Research I-ORG I-ORG Practice I-ORG Innovation I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG KYCX17_0660 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG KYTZ201402 O the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-08 O and O the O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O The O São B-ORG Paulo I-ORG Research I-ORG Foundation I-ORG financially O supported O this O study O FAPESP O 2017/01438-0 O 2017/01798-7 B-AWARD 2017/17288-8 B-AWARD 2018/22236-0 B-AWARD 2018/04954-2 B-AWARD 2021/01191-0 B-AWARD 2013/07276-1 B-AWARD CePID O CePOF O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior-Brasil I-ORG CAPES)—Finance O code O 001 B-AWARD and O National B-ORG Council I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Development I-ORG CNPq I-ORG 423945/2016-5 O Authors O thank O the O financial O support O given O by O the O São B-ORG Paulo I-ORG Research I-ORG Foundation I-ORG grant O FAPESP O project O No. O 2018/07366-4 B-AWARD awarded O to O H.U B-ORG and I-ORG a I-ORG FAPESP I-ORG Brazil)-Conicyt I-ORG Chile O grant O awarded O to O H.U O and O C.P O 201808426-0 O C.P O gratefully O acknowledges O support O from O ANID B-ORG FONDECYT I-ORG 1220831 B-AWARD I.G.-C O also O gratefully O acknowledges O support O from O ANID O FONDECYT O 11181105 B-AWARD This O work O was O supported O byProgram O 973(2009CB941703),Basic O Scientific I-ORG Research I-ORG Program I-ORG of I-ORG China(2242016K40063),Natural O Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Provinceof O China O BK20181273 O This O research O was O funded O by O an O MRC O programme O grant O and O intramural O funding O to O MALR B-ORG MR/R023883/1 O MC_UU_00005/18 B-AWARD a O Sir B-ORG Henry I-ORG Wellcome I-ORG Fellowship I-ORG 201381/Z/16/Z O to O RC, O and O a O European B-ORG Research I-ORG Council I-ORG Grant O 771863 O x2013 O FLEXSEM O to O EJ. O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFA0900704 O 2017YFC1201200 B-AWARD International B-ORG Partnership I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences O 153D31KYSB20170121 O Key B-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG KFZD-SW-219-5 O Zhangjiang B-ORG special I-ORG project I-ORG of I-ORG national I-ORG innovation I-ORG demonstration I-ORG zone I-ORG ZJ2018-ZD-013 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31871281 O and O Science O and O Technology O Service O Network O Initiative O of O Chinese O Academy O of O Sciences O Y919C11011).Conflict O of O interest O None O declared O This O research O was O funded O by O grants O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31471915 O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG province I-ORG 2015A030310325),the O Orchid I-ORG Industry I-ORG Technology I-ORG Innovation I-ORG Alliance I-ORG 2016A090924006 O and O Orchid B-ORG Technology I-ORG Demonstration I-ORG of I-ORG Guangdong I-ORG province(2013B040200041 O This O work O was O financially O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province O China O 2017DK2013 O 2018JJ3716 B-AWARD and O 2018JJ3759 B-AWARD China B-ORG Scholarship I-ORG Council I-ORG 201806375067 O 201806375068 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81372180 O and O Central B-ORG South I-ORG University I-ORG Innovation I-ORG Foundation I-ORG for I-ORG Postgraduate I-ORG Studies I-ORG NO. O 2017zzts231 O This O work O was O supported O by O the O Research B-ORG Fund I-ORG for I-ORG the I-ORG Control I-ORG of I-ORG Infectious I-ORG Diseases I-ORG Commissioned I-ORG Study I-ORG of I-ORG Food I-ORG and I-ORG Health I-ORG Bureau I-ORG of I-ORG Hong I-ORG Kong I-ORG Government I-ORG RFCID O HK-09-01-21 B-AWARD Health B-ORG and I-ORG Medical I-ORG Research I-ORG Fund I-ORG HMRF O HKM-15-M09,14130742 B-AWARD a O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 O Program O 2014CB745200 B-AWARD from O the O Ministry O of O Science O and O Technology O of O PRC O and O by O Shenzhen B-ORG Peacock I-ORG project I-ORG KQTD2015033117210153 O the O Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Committee I-ORG Basic I-ORG Science I-ORG Research I-ORG Grant I-ORG JCYJ20150629151046896 O This O research O was O funded O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Grand O No. O 2020YFC2004500 B-AWARD the O National O Key O R&D O Program O of O China O No. O 2021YFB3602200 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81902166 B-AWARD 82172077 B-AWARD 91959112 B-AWARD the O Primary B-ORG Research I-ORG I-ORG Development I-ORG Plan I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BE2019683 O the O Science B-ORG Foundation I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG No. O 2020SYHZ0041 B-AWARD Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG ZR2019MC069 O and O the O Instrument B-ORG Developing I-ORG Project I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Science I-ORG YJKYYQ20200038 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81371516 O 81501441 B-AWARD Foundation B-ORG of I-ORG National I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG China I-ORG W201306 O Social B-ORG Development I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BE2015605 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG the O Youth O Foundation O BK20150109 B-AWARD and O BK20150102 B-AWARD Research B-ORG Project I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Q201508 O Six B-ORG Talent I-ORG Peaks I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG 2015-WSN-079 O and O Key B-ORG Project I-ORG supported I-ORG by I-ORG Medical I-ORG Science I-ORG and I-ORG technology I-ORG development I-ORG Foundation I-ORG Nanjing I-ORG Department I-ORG of I-ORG Health I-ORG YKK15068 O This O work O was O supported O by O the O Guizhou B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG ZK[2023]-099 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32001452 O the O Program B-ORG of I-ORG Introducing I-ORG Talent I-ORG to I-ORG Chinese I-ORG Universities I-ORG 111 O Program O D20023 B-AWARD the O Frontiers B-ORG Science I-ORG Center I-ORG for I-ORG Asymmetric I-ORG Synthesis I-ORG and I-ORG Medicinal I-ORG Molecules I-ORG Department I-ORG of I-ORG Education I-ORG Guizhou I-ORG Province I-ORG Qianjiaohe O KY I-AWARD 2020)004 O and O Hong B-ORG Kong I-ORG Research I-ORG Grant I-ORG Council I-ORG AoE/M-403/16 O GRF12100318 B-AWARD 12103219 B-AWARD 12103220 B-AWARD 12101722 B-AWARD This O study O was O supported O by O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 61634003 B-AWARD 61571221 B-AWARD 11774155 B-AWARD 61921005 B-AWARD and O 61735008 B-AWARD and O the O National B-ORG Key I-ORG R&D I-ORG program I-ORG of I-ORG China I-ORG 2018YFB2200101 O Research B-ORG Fund I-ORG for I-ORG the I-ORG Doctoral I-ORG Program I-ORG of I-ORG the I-ORG Higher I-ORG Education I-ORG of I-ORG China I-ORG Grant O No. O 20130091110024 B-AWARD Six B-ORG Talent I-ORG Peaks I-ORG Project I-ORG in I-ORG Jiangsu I-ORG Province I-ORG DZXX-001 O This O project O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81402236 O National O Natural O Science O Foundation O of O China O 81772887 O the B-ORG Priority I-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O 2014-37 B-AWARD Jiangsu B-ORG Provincial I-ORG Medical I-ORG Innovation I-ORG Team I-ORG CXTDA2017036 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG of I-ORG China I-ORG BK20171488 O and O Jiangsu B-ORG Provincial I-ORG Medical I-ORG Youth I-ORG Talent I-ORG QNRC2016854 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 41701347 B-AWARD The O field O trip O and O APC O are O also O Supported O by O the O Foundation O of O Key O Laboratory O of O Soft O Soils O and O Geoenvironmental O Engineering O Zhejiang O University O Ministry O of O Education O no. O 2019P04 B-AWARD and O Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG no. O 2019YJ0244 B-AWARD This O research O was O funded O by O the O National B-ORG Institute I-ORG of I-ORG Environmental I-ORG Health I-ORG Sciences O Grant/Award O Number O TOX B-AWARD T32 I-AWARD ES007028 O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG of I-ORG the I-ORG National I-ORG Institutes I-ORG of I-ORG Health O Award O Numbers O T32GM007628 B-AWARD 1SC1AI127352 B-AWARD 5R25GM059994 B-AWARD 1F31AI67579 B-AWARD and O U54MD007586 B-AWARD the O Veterans B-ORG Administration O Grant/Award O Number O I01BX002583 B-AWARD and O the O Bill B-ORG I-ORG Melinda I-ORG Gates I-ORG Foundation I-ORG INV-03510 B-AWARD This O work O was O jointly O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2019YFA0906500 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 91951113 B-AWARD and O the O Innovation B-ORG Team I-ORG Project I-ORG of I-ORG Colleges I-ORG and I-ORG Universities I-ORG in I-ORG Jinan I-ORG Grant O No. O 2019GXRC033 B-AWARD This O study O was O supported O by O the O National O Research O Initiative O Competitive O Grants O 2011-68002-30029 B-AWARD and I-AWARD 2017-67007-25939 I-AWARD from O the O USDA O National B-ORG Institute I-ORG of I-ORG Food I-ORG and I-ORG Agriculture O the O Idaho B-ORG Agricultural I-ORG Experimental I-ORG Station I-ORG Project O IDA01627 B-AWARD the O Idaho B-ORG Wheat I-ORG Commission I-ORG Project O BJKW32 B-AWARD and O the O China B-ORG Scholarship I-ORG Council I-ORG Grant O 201406300139 B-AWARD Dr. O Ying O Liu O was O supported O by O Dalian B-ORG Medical I-ORG Science I-ORG Research I-ORG Project I-ORG No. O 1712037 B-AWARD Dr. O Yongzhong O Lin O was O supported O by O Chinese B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 81571237 B-AWARD and O Liaoning B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG No. O 2017225070 B-AWARD These O funding O were O used O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U1333119 B-AWARD National B-ORG Defense I-ORG Basic I-ORG Scientific I-ORG Research I-ORG program I-ORG of I-ORG China I-ORG JCKY2013605B002 B-AWARD Fund B-ORG of I-ORG Shanghai I-ORG Engineering I-ORG Research I-ORG Center I-ORG of I-ORG Civil I-ORG Aircraft I-ORG Health I-ORG Monitoring I-ORG GCZX-2015-05 B-AWARD and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 56XBC18206 B-AWARD 56XBA18201 I-AWARD to O YG. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O present O investigation O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31701851 O the B-ORG Joint I-ORG Foundation I-ORG of I-ORG Two I-ORG Sides I-ORG of I-ORG Strait I-ORG YS2017YFGH000833 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province O China O 2016J01130 O and O the O Science O Foundation O of O Fujian O Academy O of O Agricultural O Sciences O AB2017-5 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81770846 B-AWARD and O No. O 81803024 B-AWARD Hirshberg B-ORG Foundation I-ORG for I-ORG Pancreatic I-ORG Cancer I-ORG Research I-ORG GX20171003858 O and O GX20191005878 B-AWARD and O Fundamental B-ORG Research I-ORG Funds I-ORG from I-ORG the I-ORG Dalian I-ORG Universities I-ORG of I-ORG Technology I-ORG under O Grant O No. O DUT17ZD308 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by: O National B-ORG Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases,http://dx.doi.org/10.13039/100000060 O RO1AI093640 B-AWARD to O AS; O Howard B-ORG Hughes I-ORG Medical I-ORG Institute,http://dx.doi.org/10.13039/100000011 O Early B-AWARD Career I-AWARD Scientist I-AWARD Award O to O AS; O A.P B-ORG Giannini I-ORG Foundation,http://dx.doi.org/10.13039/100002112 O AP B-AWARD Giannini I-AWARD Postdoctoral I-AWARD Research I-AWARD Fellowship O to O NVP O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O research O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 52076063 B-AWARD and O 52100035 B-AWARD the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG No. O 2019YFC0408503 B-AWARD the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No.HIT.OCEF.2021031 O and O the B-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Urban I-ORG Water I-ORG Resource I-ORG and I-ORG Environment I-ORG Harbin O Institute O of O Technology O No. O 2022TS41 B-AWARD This O study O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31872068 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2018YFD1000200 O the O Funds B-ORG of I-ORG Shandong I-ORG “Double I-ORG Tops” I-ORG Program I-ORG SYL2017YSTD10 O and O China’s B-ORG Agricultural I-ORG Research I-ORG System I-ORG CARS-29 O None O of O the O funding O bodies O have O any O role O in O the O design O of O the O study O or O collection O analysis O and O interpretation O of O data O as O well O as O in O writing O the O manuscript O This O study O was O funded O by O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2018M642648 B-AWARD the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG the I-ORG Microbial I-ORG Technology I-ORG Open I-ORG Projects I-ORG Fund I-ORG No. O M2021-17 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG No. O ZR2021MC038 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG the I-ORG Jinan I-ORG Municipal I-ORG Health I-ORG Commission I-ORG No. O 2019-1-25 B-AWARD National B-ORG Key I-ORG Research I-ORG Project O 2018ZX10101003-005-001 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O 31870156 B-AWARD National B-ORG Key I-ORG Lab I-ORG Research I-ORG program O SKLPBS1811 B-AWARD This O work O was O supported O by O the O grants O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Nos O 2016YFC1101400 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81991504 B-AWARD and O 81870768 B-AWARD and O the O Guangzhou B-ORG Science I-ORG Technology I-ORG and I-ORG Innovation I-ORG Commission I-ORG 201803040008 O 201704030024 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O grants O from O the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Grant O Number O 2020YFC2002800 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Number O 31872973 B-AWARD and O Yunnan B-ORG Key I-ORG Laboratory I-ORG of I-ORG Innovative I-ORG Application I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG Grant O Number O 202105AG070032 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31671607 O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0300202 O and O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Projects I-ORG for I-ORG Cultivation I-ORG of I-ORG New I-ORG Transgenic I-ORG Varieties I-ORG 2018ZX0800917B O The O funding O bodies O provided O only O the O experimental O cost O including O data O collection O and O publication O fee O for O this O study O However O the O experimental O design O data O analysis O and O interpretation O and O writing O the O manuscript O were O managed O by O the O contributing O authors O This O work O was O supported O by O the O Austrian B-ORG Science I-ORG Fund I-ORG grant O number O I3808 B-AWARD the O Deutsche B-ORG Forschungsgemeinschaft I-ORG DFG O project O number O LE B-AWARD 3744/4-1 O and O the O Schweizerischer B-ORG Nationalfonds I-ORG SNF O project O number O 310030E_179552 B-AWARD The O APC O was O funded O by O MDPI O This O work O was O supported O by O the O Open B-ORG Fund I-ORG of I-ORG State I-ORG Laboratory I-ORG of I-ORG Information I-ORG Engineering I-ORG in I-ORG Surveying I-ORG Mapping I-ORG and I-ORG Remote I-ORG Sensing I-ORG Wuhan I-ORG University I-ORG grant O number O 17R05 B-AWARD to O Dr. O Jian O Yang O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG China I-ORG University I-ORG of I-ORG Geosciences I-ORG Wuhan I-ORG grant O number O CUG170661 B-AWARD to O Dr. O Jian O Yang O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 41571370 B-AWARD to O Shuo O Shi O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG grant O number O 2015CFA002 B-AWARD to O Wei O Gong O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O CORFO B-ORG IFAN I-ORG 16PTECAI–66648–P19 B-AWARD DGI–UNAB B-ORG DI–01–21/NUC O VRID–UNAB B-ORG APP–1 B-AWARD 2022 O ANID B-ORG PIA/BASAL I-ORG FB0002 B-AWARD ANID B-ORG Millennium I-ORG Science I-ORG Initiative I-ORG Program I-ORG ICN B-AWARD 2019_015 O and O CNRS B-ORG International I-ORG Research I-ORG Network I-ORG Diversity I-ORG and I-ORG Biotechnology I-ORG of I-ORG Marine I-ORG Algae I-ORG contract O number O 00022 B-AWARD This O work O was O kindly O supported O by O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG No. O 2021CXGC010808 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG No. O 2021YFD2100300 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 32272246 B-AWARD No. O 31901730 B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Science I-ORG Foundation I-ORG Plant O Genome O Research O Program O IOS-1546218 O the O Zegar B-ORG Family I-ORG Foundation I-ORG A16-0051 O and O the O NYU B-ORG Abu I-ORG Dhabi I-ORG Research I-ORG Institute I-ORG G1205 O to O M.D.P O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Taiwan O 108-2636-M-002-012 B-AWARD Council B-ORG of I-ORG Agriculture O 106AS-15.2.2-IE-b1 B-AWARD and I-AWARD 1082101021901-110201b1 O National B-ORG Taiwan I-ORG University O 108L7410 B-AWARD This O study O has O been O supported O by O Russian B-ORG Foundation I-ORG for I-ORG Basic I-ORG Research I-ORG RFBR O grant O No. O 14-04-01881 B-AWARD BOR B-ORG grant O VI.62.1.4 B-AWARD and O Presidium B-ORG of I-ORG RAS I-ORG research I-ORG program I-ORG ‘Molecular I-ORG and I-ORG Cellular I-ORG Biology’ I-ORG No. O 6.1 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Research O reported O in O this O publication O was O supported O in O part O by O the O Defense B-ORG Advanced I-ORG Research I-ORG Projects I-ORG Agency I-ORG DARPA O D19AP00024 O DARPA O Young O Faculty O Award,https://www.darpa.mil/work-with-us/for-universities/young-faculty-award O the O National B-ORG Institute I-ORG of I-ORG Biomedical I-ORG Imaging I-ORG and I-ORG Bioengineering I-ORG DP2EB024245 O NIH O Director's O New O Innovator O Award O Program,https://commonfund.nih.gov/newinnovator O and O the O National B-ORG Cancer I-ORG Institute I-ORG R21CA236640 O R33CA247739 B-AWARD of O the O National O Institutes O of O Health O NIH O The O Russian B-ORG Science I-ORG Foundation I-ORG grant O 17-15-013418 O supported O this O study O This O was O supported O in O part O by O the O contracts O of O the O Ministry O of O Education O and O Science O of O the O Russian O Federation O with O South O Ural O State O University O 17.7255.2017/8.9 O and O Institute O of O Immunology O and O Physiology O AAAA-A18-118020690020-1 O The O work O was O furthermore O supported O by O institutional O funds O from O the O State O University O of O New O York O SUNY O Upstate O Medical O University O This O work O is O part O of O the O TransCampus O project O between O TU O Dresden O and O King’s O College O London O and O was O partially O supported O by O the O U.S B-ORG Department I-ORG of I-ORG Veterans I-ORG Affairs I-ORG 5101CX001219 O and O the O U.S B-ORG Department I-ORG of I-ORG Defense I-ORG W81XWH-16-1-0773 O This O study O was O supported O by O the B-ORG Independent I-ORG topics I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG traditional I-ORG Chinese I-ORG Medicine I-ORG No. O zz0708121 B-AWARD 2011zdxk O the O Science B-ORG and I-ORG technology I-ORG basic I-ORG work I-ORG of I-ORG science I-ORG and I-ORG technology I-ORG No. O 2013FY114500 B-AWARD and O Key B-ORG project I-ORG at I-ORG central I-ORG government I-ORG level I-ORG No. O 2060302 B-AWARD The O funders O played O no O role O in O the O design O of O the O study O data O collection O and O analysis O or O the O decision O to O publish O and O prepare O the O manuscript O This O work O was O supported O by O the O Medical B-ORG Research I-ORG Council I-ORG Grant O no. O MR/P006493/1 B-AWARD Imperial B-ORG College I-ORG NIHR I-ORG Biomedical I-ORG Research I-ORG Centre I-ORG Grant O no. O P64219_WMCT B-AWARD Imperial B-ORG Charity I-ORG Grant O no. O GG1516\100028 B-AWARD We O thank O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31500221 B-AWARD No. O 31660057 B-AWARD No. O 31590823 B-AWARD and O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Pan-Third I-ORG Pole I-ORG Environment I-ORG Study I-ORG for I-ORG a I-ORG Green I-ORG Silk I-ORG Road I-ORG Pan-TPE O Grant O No. O XDA2004010306 B-AWARD for O support O of O the O sample O collecting O and O the O RNA O sequencing O analysis O We O also O thank O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Yunnan I-ORG Province I-ORG No. O 2019FB056 B-AWARD for O support O of O physiological O and O biochemical O analyses O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of O China O No. O 21303041 B-AWARD 11504332 I-AWARD 11774078 I-AWARD U1604131 I-AWARD 11804081 I-AWARD and I-AWARD 11804082 O by O the O Innovation O Scientists O and O Technicians O Troop O Construction O Projects O of O Henan O Province O No. O CXTD2017089 O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Henan I-ORG Province I-ORG No. O 162300410116 B-AWARD and I-AWARD 162300410254 O by O the O Foundation B-ORG of I-ORG Henan I-ORG Educational I-ORG Committee I-ORG No. O 15A416007 B-AWARD 16A140019 I-AWARD 16A140009 I-AWARD 18A140018 I-AWARD and I-AWARD 19A140009 O by O the O Beijing O National O Laboratory O for O Molecular O Science O No. O 20150144 O by O the O Program O for O Innovative O Research O Team O of O Henan O Polytechnic O University O No. O T2016-2 O by O the O Fundamental O Research O Funds O for O the O Universities O of O Henan O Province O No. O 140132 O and O by O the O Doctoral O Foundation O of O Henan O Polytechnic O University O B2018-37 O and O B2018-38 O This O project O has O been O funded O by O a O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG CIHR O operating O grant O MOP192552 B-AWARD to O GS O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31371757 B-AWARD to O XG O State B-ORG Key I-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31330060 B-AWARD to O XG O Shandong B-ORG province I-ORG key I-ORG R I-ORG I-ORG D I-ORG projects I-ORG key I-ORG technologies I-ORG NO.2016ZDJS06A01 O to O XG O The B-ORG People’s I-ORG Livelihoods I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Qingdao I-ORG Shandong I-ORG Province I-ORG China I-ORG NO.17-3-3-68-nsh O to O XG) O and O China B-ORG Scholarship I-ORG Council I-ORG No. O 2014]3026 B-AWARD to O XG O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O nos O 21572222 B-AWARD 21708037 B-AWARD 21877108 B-AWARD the O Innovative B-ORG Team I-ORG of I-ORG Sichuan I-ORG Province I-ORG grant O no. O 2017TD0021 B-AWARD Chengdu B-ORG Municipal I-ORG Bureau I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG grant O nos O 2015-HM02-00099-SF B-AWARD 2016-HM01-00371-SF B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG grant O no. O 2017M612998 B-AWARD We O thank O the O EC B-ORG FP7 I-ORG 4DCellFate O project O 277899 O the O Medical B-ORG Research I-ORG Council I-ORG MR/P019471/1 O MR/M010082/1 O and O the O Wellcome B-ORG Trust I-ORG 082010/Z/07/Z O 206291/Z/17/Z O for O financial O support O European O Community‘s O Seventh B-ORG Framework I-ORG Programme I-ORG FP7/2007-2013 O Grant O no. O 602108 O through O the O PREDICTION-ADR O project O to O M.K.S O C.M O D.C O K.B O M.P O M.W O A.A O A.H.M O and O C.N.A.P O PREDICTION-ADR O cohort O used O individuals O from O the O SHARE O Bioresource O GoSHARE O and O SHARE O has O ongoing O funding O from O NHS O Research O Scotland O and O established O by O funding O from O The O Wellcome B-ORG Trust I-ORG Biomedical O Resource O Grant O No. O 099177/Z/12/Z O The O GoDARTS O study O was O funded O by O The O Wellcome O Trust O Award O 072960 B-AWARD and I-AWARD 084726 O and O the O UK O Medical B-ORG Research I-ORG Council I-ORG Award O G0601261 O Genetic O analysis O in O the O JUPITER O trial O was O supported O by O a O research O grant O from O AstraZeneca O jointly O to O D.I.C O and O P.M.R O Recruitment O of O Swedish O patients O was O supported O by O the O Swedish B-ORG Research I-ORG Council I-ORG Medicine O 521-2011-2440 B-AWARD and I-AWARD 521-2014-3370 O Swedish O Heart O and O Lung O Foundation O 20120557 O and O 20140291 O the O Medical O Products O Agency O Selander‘s O Foundation O Thureus’ O Foundation O and O the O Clinical O Research O Support O ‘Avtal O om O Läkarutbildning O och O Forskning’ O at O Uppsala O University O Sweden O CPRD-STAGE O was O funded O by O a O grant O from O the O e-Health O Initiative O funded O jointly O by O the O Medical O Research O Council O reference O MC_qA137929 B-AWARD the O Wellcome O Trust O the O Engineering O and O Physical O Sciences O Research O Council O and O The O Economic O and O Social O Research O Council O M.P O is O a O National O Institute O for O Health O Research O senior O investigator O We O are O grateful O for O the O financial O support O provided O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 42130405 B-AWARD and O 42171402 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG of I-ORG China I-ORG No. O 22KJB170016 B-AWARD and O the O Foundation B-ORG of I-ORG Anhui I-ORG Province I-ORG Key I-ORG Laboratory I-ORG of I-ORG Physical I-ORG Geographic I-ORG Environment I-ORG No. O 2022PGE013 B-AWARD This O work O is O financially O supported O by O the O Science B-ORG I-ORG Technology I-ORG Research I-ORG Project I-ORG of I-ORG Ningxia I-ORG Education I-ORG Department I-ORG NGY2018-141 O the O Talent B-ORG Scientific I-ORG Research I-ORG Fund I-ORG of I-ORG LSHU I-ORG no. O 2016XJJ-010 B-AWARD the O 2016 B-ORG General I-ORG Project I-ORG of I-ORG Education I-ORG Department I-ORG of I-ORG Liaoning I-ORG Province I-ORG no. O L2016003 B-AWARD the O Doctoral B-ORG Research I-ORG Fund I-ORG of I-ORG Liaoning I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG no. O 20170520158 B-AWARD and O the O Opening B-ORG Funds I-ORG of I-ORG Key I-ORG Lab I-ORG of I-ORG Beifang I-ORG University I-ORG of I-ORG Nationalities I-ORG no. O 1605 B-AWARD This O work O is O funded O by O Guangdong B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2015A030313171 O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG 2013B020400003 O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG China I-ORG 15570001 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81200685 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O UNAM-PAPIIT B-ORG IA202021 O IA205423 O the O Consejo B-ORG Nacional I-ORG de I-ORG Ciencia I-ORG y I-ORG Tecnología I-ORG Conacyt I-ORG de I-ORG México I-ORG Grant O O 254686 B-AWARD to O D.M.-F O and O by O the O Conacyt O Ciencia O Básica O y/o O Ciencia O de O Frontera O Modalidad O Paradigmas B-ORG y I-ORG Controversias I-ORG de I-ORG la I-ORG Ciencia I-ORG 2022 O Grant O O 319433 B-AWARD to O L.O.S.-R O The O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81601178 B-AWARD Major B-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81430043 B-AWARD Project B-ORG of I-ORG science I-ORG and I-ORG technology I-ORG of I-ORG social I-ORG development I-ORG in I-ORG Shaanxi I-ORG Province I-ORG 2016SF-049 O and O Military B-ORG Medical I-ORG Science I-ORG and I-ORG technology I-ORG youth I-ORG training I-ORG project I-ORG 15QNP069 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 62101432 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation O grant O number O 2022M722558 B-AWARD the O Fundamental B-ORG Research I-ORG Program I-ORG of I-ORG Shanxi I-ORG Province O grant O number O 20210302123182 B-AWARD the O Research B-ORG Project I-ORG of I-ORG Shanxi I-ORG Scholarship I-ORG Council I-ORG of I-ORG China O grant O numbers O 2020-036 B-AWARD 2022-069 B-AWARD the O Scientific B-ORG Research I-ORG Fund I-ORG of I-ORG Zhejiang I-ORG Provincial I-ORG Education I-ORG Department O grant O number O Y202146138 B-AWARD and O the O University B-ORG Enterprise I-ORG Cooperation I-ORG Project O grant O number O FG2022314 B-AWARD This O work O was O supported O by O the O National O Natural O Science O Foundation O of O China O 31801035 O National B-ORG Postdoctoral I-ORG Program I-ORG for I-ORG Innovative I-ORG Talents I-ORG BX201800113 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG 2018CFB223 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M640708 O PW O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81160354 O and O the B-ORG Yunnan I-ORG Provincial I-ORG Training I-ORG Program I-ORG of I-ORG Young I-ORG Academic I-ORG and I-ORG Technical I-ORG Leader I-ORG 2014HB037 O WL O was O funded O by O the B-ORG National I-ORG Priority I-ORG Development I-ORG Project I-ORG on I-ORG Key I-ORG Science I-ORG Instrument I-ORG 2012YQ09019706 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61903285 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG of O China O 2019CFB559 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG WUT O 2020IVB031 I-AWARD WUT I-AWARD 2020IB003 I-AWARD WUT I-AWARD 2020IA005 I-AWARD WUT I-AWARD 2019IB012 O WUT O 2019IB012 O The O Grants-in-Aid O supported O this O study O financially O only O and O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O nor O in O writing O the O manuscript O This O work O was O partially O supported O by O a O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O grant O Grant O NO: O 81471781 B-AWARD and O a O National B-ORG Major I-ORG Scientific I-ORG Instruments I-ORG and I-ORG Equipment I-ORG Development I-ORG Projects I-ORG Grant O NO: O 2012YQ160203 B-AWARD to O Dr. O Shengrong O Sun O an O NSFC O grant O to O Dr. O Juanjuan O Li O Grant O NO: O 81302314 B-AWARD and O Hubei B-ORG Province I-ORG health I-ORG and I-ORG family I-ORG planning I-ORG scientific I-ORG research I-ORG project I-ORG WJ2019Q044 O to O Dr. O Sun O Si. O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32202638 O National B-ORG Key I-ORG R&D I-ORG program I-ORG of I-ORG China I-ORG 2021YFD1200902 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG China I-ORG BK20221018 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2022M721649 O Jiangsu B-ORG Funding I-ORG Program I-ORG for I-ORG Excellent I-ORG Postdoctoral I-ORG Talent I-ORG 2022ZB336 O Key B-ORG Project I-ORG for I-ORG Jiangsu I-ORG Agricultural I-ORG New I-ORG Variety I-ORG Innovation I-ORG PZCZ201740 O and O Hainan B-ORG Yazhou I-ORG Bay I-ORG Seed I-ORG Lab I-ORG B21HJ1003 O This O work O was O supported O by O the O National B-ORG key I-ORG R&D I-ORG program I-ORG of I-ORG China I-ORG 2021YFD1301002 O the O Tianjin B-ORG Synthetic I-ORG Biotechnology I-ORG Innovation I-ORG Capacity I-ORG Improvement I-ORG Project I-ORG TSBICIP-CXRC-031 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation-funded I-ORG project I-ORG 2021M703439 O and O Tianjin B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 22ZYJDSS00050 O This O work O was O supported O by O grants O from O the O Medical B-ORG Technology I-ORG Foundation I-ORG of I-ORG Henan I-ORG Province I-ORG 142300410025 O and O 112102310211 B-AWARD Scientific B-ORG Research I-ORG Fund I-ORG of I-ORG Xinxiang I-ORG Medical I-ORG University I-ORG 2013ZD117 O and O Ministry B-ORG of I-ORG Health I-ORG research I-ORG fund I-ORG projects I-ORG in I-ORG China I-ORG 20090103 O Henan B-ORG Provincial I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Project I-ORG 102101310400 O This O work O was O supported O by O grants O from O the O Young B-ORG Scientists I-ORG Fund I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31101548 B-AWARD the O Special B-ORG Fund I-ORG for I-ORG Agro-scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG No. O 201303014 B-AWARD the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-25 O and O the O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG CAAS-ASTIP-IVFCAAS O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Cellular O samples O experimental O animal O and O sectional O experiment O reagents O were O supported O by O the O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81801515 O 81801494 B-AWARD 81801478 O partial O experiment O reagents O were O acquired O by O Suzhou B-ORG introduce I-ORG expert I-ORG team I-ORG of I-ORG clinical I-ORG medicine I-ORG SZYJTD201708 O SZYJTD201707 B-AWARD and O Suzhou B-ORG talent I-ORG training I-ORG program I-ORG GSWS2019005 O and O the O Suzhou O Key O Medical O Center O SZZX201505 O supported O the O salary O of O the O postdoctors O in O this O paper O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 52172298 B-AWARD and O 51873102 B-AWARD the O Innovation O Program O of O Shanghai B-ORG Municipal I-ORG Education I-ORG Commission I-ORG Grant O No. O 2019-01-07-00-09-E00020 B-AWARD and O the O Independent O deployment O project O of O Qinghai B-ORG Institute I-ORG of I-ORG Salt I-ORG Lakes I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG No. O E260GC0401 B-AWARD This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32202568 O and O Beijing B-ORG Academy I-ORG of I-ORG Agriculture I-ORG and I-ORG Forestry I-ORG Sciences I-ORG KJCX20230808 O China O This O work O was O partially O funded O by O Key B-ORG Research I-ORG and I-ORG Development I-ORG Planning I-ORG Project I-ORG in I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Hebei I-ORG Province I-ORG 21326315D O Beijing B-ORG Agriculture I-ORG Innovation I-ORG Consortium I-ORG BAIC03-02 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81803365 B-AWARD Post-Doctor B-ORG Research I-ORG Project I-ORG 2018M643510 O 2019M650213 B-AWARD The O National B-ORG Key I-ORG R I-ORG I-ORG D I-ORG Program I-ORG of I-ORG China I-ORG 2018ZX09735005 O 2017YFA0503900 B-AWARD Foundation B-ORG Committee I-ORG of I-ORG basic I-ORG and I-ORG applied I-ORG basic I-ORG research I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2019B1515120029 O 2019A1515110482 B-AWARD and O Shenzhen B-ORG Natural I-ORG Science I-ORG Foundation I-ORG JCYJ20190808171803553 O Post-Doctor B-ORG Research I-ORG Project I-ORG of I-ORG West I-ORG China I-ORG Hospital I-ORG Sichuan I-ORG University I-ORG Grant O No. O 2018HXBH065].Figure B-AWARD 8are O created O with O BioRender.com O we O thank O this O professional O website O and O we O appreciate O their O generosity O and O kindness O This O research O was O funded O by O FAPESP B-ORG #2017/02317-2 O CNPq B-ORG #304389/2019-6 O and O 401256/2020-0 O CAPES B-ORG #88881.504639/2020-01 O and O the O National O Institute O of O Science O and O Technology O in O Bioanalytics O FAPESP O 2014/50867-3 O CNPq O 465389/2014-7 O and O partially O supported O by O CNPq O 403701-2020-1 O and O FINEP O O 01.20.0009.00 O grants O This O work O was O funded O by O the O key O project O of O the O Education B-ORG Department I-ORG of I-ORG Guizhou I-ORG Province I-ORG KY(2013)186 O Science B-ORG Department I-ORG of I-ORG Guizhou I-ORG Province I-ORG (2015)6013 B-AWARD and O (2016)5202 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31560091 O National B-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG Science I-ORG Foundation I-ORG 2019-WJ-04 O Fujian B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 2018Y0005 O Fujian B-ORG Provincial I-ORG Health I-ORG Technology I-ORG Project I-ORG 2017-CX-11 O Key B-ORG Clinical I-ORG Specialty I-ORG Discipline I-ORG Construction I-ORG of I-ORG Fujian I-ORG P.R.C O [2015 O 593 O This O study O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81622017 O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC1301503 O and O the B-ORG Science I-ORG Technology I-ORG Department I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2018C04011 O The O funders O sponsors O played O no O part O in O the O study O design O the O collection O management O analysis O and O interpretation O of O data O the O writing O of O the O report O or O the O decision O to O submit O the O report O for O publication O This O research O was O supported O by O National B-ORG Institute I-ORG on I-ORG Aging I-ORG Grant O Nos O R01AG032282 B-AWARD and O R01AG049789 B-AWARD and O UK O Medical B-ORG Research I-ORG Council I-ORG Grant O No. O MR/P005918 B-AWARD Additional O support O was O provided O by O the O Jacobs O Foundation O M.L.E O is O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG Graduate O Research O Fellowship O Grant O No. O NSF O DGE-1644868 B-AWARD The O Dunedin O Multidisciplinary O Health O and O Development O Study O is O supported O by O the O New O Zealand O Health O Research O Council O and O the O New O Zealand O Ministry O of O Business O Innovation O and O Employment O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O numbers O 81701513 B-AWARD and O 8177060587 B-AWARD Specialized B-ORG Research I-ORG Fund I-ORG for I-ORG New I-ORG Teachers I-ORG of I-ORG Chinese I-ORG Higher I-ORG Education I-ORG Doctoral I-ORG Program I-ORG Grant O number O 20130071120095 B-AWARD and O the O Merck-Serono B-ORG Chinese I-ORG Research I-ORG Fund O MerckSerono_CREATE-2016116 B-AWARD The O funding O sources O had O no O other O involvement O in O this O study O or O in O the O preparation O of O the O report O The O study O was O funded O by O the O 1) O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG W.Z O grant O number O 82260555 B-AWARD 2) O Traditional B-ORG Chinese I-ORG Medicine I-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG Gansu I-ORG Province I-ORG China I-ORG W.Z O grant O number O GZKP-2020-28 B-AWARD 3) O Science B-ORG and I-ORG Technology I-ORG Projects I-ORG of I-ORG Chengguan I-ORG District I-ORG in I-ORG Lanzhou I-ORG W.Z O grant O number O 2020-2-11-4 B-AWARD and O 4) O Medical B-ORG Innovation I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG Lanzhou I-ORG University I-ORG W.Z O grant O number O lzuyxcx-2022-177 B-AWARD This O research O was O funded O by O the O State O Key O Laboratory O of O Veterinary O Biotechnology O Foundation O grant O no. O SKLVBF201908 O the O Heilongjiang B-ORG Province I-ORG Postdoctoral I-ORG Science I-ORG Foundation O grant O no. O LBH-Q17139/LBH-Z18259 B-AWARD the O Program O for O Young O Scholars O with O Creative O Talents O in O Heilongjiang O Bayi O Agricultural O University O grant O no. O CXRC2017005 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Province O grant O no. O C2016043 B-AWARD the O graduate O students O research O foundation O of O Heilongjiang O Bayi O Agricultural O University O grant O no. O YJSCX2019-Y33 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O no. O 31472209/31873011 B-AWARD The O Medical B-ORG Research I-ORG Council I-ORG MC_UU_00007/15 O to O C.P.P O Action B-ORG for I-ORG ME I-ORG and I-ORG the I-ORG Chief I-ORG Scientist I-ORG Office I-ORG Scotland I-ORG AME/CSO/18/01 O the O Medical B-ORG Research I-ORG Council I-ORG and I-ORG National I-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG for O funding O the O DecodeME O GWAS O project O MC_PC_20005 O The O following O grants O funded O this O work O NIH B-ORG SCORE I-ORG Grant O 1SC1GM092297-01A1 B-AWARD GAU O NSF B-ORG Grant O CNS-1248109 B-AWARD GAU O and O Howard B-ORG Hughes I-ORG Medical I-ORG Institute I-ORG Science I-ORG Education I-ORG Grant O 5200693 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O financially O supported O by O Shanghai B-ORG University I-ORG of I-ORG Engineering I-ORG Science I-ORG E3-0501-18-01021 O Qdai-Jump O Research O from O Kyushu B-ORG University I-ORG No. O 28325 B-AWARD the O Ministry B-ORG of I-ORG Education I-ORG Culture I-ORG Sports I-ORG Science I-ORG and I-ORG Technology I-ORG MEXT O of O Japan O No. O 16H04539 B-AWARD No. O 26220909 B-AWARD and O 15K14183 B-AWARD The O authors O declare O that O the O funding O agencies O listed O below O played O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O Generous O support O for O these O studies O provided O by: O National B-ORG Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases I-ORG AI118582 O to O Dr. O David O G. O Russell O National B-ORG Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute I-ORG HL100928 O to O Dr. O David O G. O Russell O Wellcome B-ORG Trust I-ORG 088696/Z/09/Z O to O Dr. O Henry O C. O Mwandumba O Bill B-ORG and I-ORG Melinda I-ORG Gates I-ORG Foundation I-ORG OPP1125279 O to O Dr. O Henry O C. O Mwandumba O NIH B-ORG Office I-ORG of I-ORG the I-ORG Director I-ORG T32OD011182 O to O Mr. O David O W. O Gludish O This O work O was O supported O by O the O Bill B-ORG and I-ORG Melinda I-ORG Gates I-ORG Foundation O Seattle O WA O grant O OPP38580_01 B-AWARD the O Saarland B-ORG Government O Saarbruecken O Germany O grant O 01/2014 B-AWARD and O partially O funded O by O the O State B-ORG Chancellery I-ORG of I-ORG the I-ORG federal I-ORG state I-ORG Saarland I-ORG Germany O grant O number O C/1-LdZ-2011 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O project O is O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 41465002 B-AWARD 41530531 I-AWARD 41375038 O the B-ORG National I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2013CB430204 B-AWARD the O key B-ORG Special I-ORG Scientific I-ORG Research I-ORG Fund I-ORG of I-ORG Meteorological I-ORG Public I-ORG Welfare I-ORG Profession I-ORG of I-ORG China I-ORG Grant O No. O GYHY201506001 B-AWARD and O the B-ORG Science I-ORG Research I-ORG Project I-ORG of I-ORG the I-ORG Inner I-ORG Mongolian I-ORG Autonomous I-ORG Region I-ORG high I-ORG school I-ORG Grant O No.NJZY16006 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O The O Coordination O for O the O Improvement O of O Higher O Education O Personnel O CAPES B-ORG Grant O BEX-6193 B-AWARD Partial O funding O for O this O work O came O from O UEPB/PROPESQ B-ORG Grant O 2.08.04.00-8-389/2017-1 B-AWARD and O Wellcome B-ORG Trust I-ORG Training O fellowship O in O Public O Health O and O Tropical O Medicine O Grant O 209305/Z/17/Z B-AWARD to O WFSM O This O study O was O supported O by O grants O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2017YFD0501004 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG Grant O No. O K3380217115 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No. O Z109021709 B-AWARD The O funders O play O no O role O in O the O experiment O design O of O this O study O This O study O was O supported O by O the O “National O Key I-ORG R&D I-ORG Program I-ORG of I-ORG China” O No. O 2017YFC0505905 O to O Jian O Liu O the O “Natural O Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG China” O No. O ZR2017MC013 O to O Jian O Liu O and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG of I-ORG Shandong I-ORG University I-ORG No. O 2015JC023 O to O Jian O Liu O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0501009 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31272620 O and O the B-ORG Chengdu I-ORG Giant I-ORG Panda I-ORG Breeding I-ORG Research I-ORG Foundation I-ORG CPF2015-4 O This O study O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81672452 O National O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2018B0303110015 O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG 201707010354 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31320103922 B-AWARD and O No. O 31230061 B-AWARD and O National B-ORG Key I-ORG Project I-ORG of I-ORG Fundamental I-ORG Scientific I-ORG Research I-ORG “973” O Programs O No. O 2011CB100404 B-AWARD in O China O and O the B-ORG Fellowship I-ORG of I-ORG Outstanding I-ORG PhD I-ORG Students I-ORG at I-ORG Fujian I-ORG Agriculture I-ORG and I-ORG Forestry I-ORG University I-ORG 324-1122yb023 O XY O is O supported O by O the O Minjiang O Scholar O Program O in O Fujian O Province O PRC O and O the O Advanced O Talents O of O SAFEA O This O project O was O funded O by O grants O awarded O to O Ricardo O A. O Scrosati O by O the O Natural B-ORG Sciences I-ORG and I-ORG Engineering I-ORG Research I-ORG Council I-ORG of I-ORG Canada I-ORG Discovery O Grant O 311624 B-AWARD the O Canada B-ORG Foundation I-ORG for I-ORG Innovation I-ORG Leaders O Opportunity O Grant O 202034 B-AWARD the O Canada B-ORG Research I-ORG Chairs I-ORG program I-ORG CRC O Grant O 210283 B-AWARD and O by O a O postdoctoral O fellowship O #91617093 O awarded O to O Julius O A. O Ellrich O by O the O German B-ORG Academic I-ORG Exchange I-ORG Service I-ORG DAAD O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Doctoral B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Dali I-ORG University I-ORG KY1819212210 O the O Key B-ORG Technology I-ORG Project I-ORG in I-ORG Yunnan I-ORG Province I-ORG of I-ORG China I-ORG 201800501 O and O the O Innovation B-ORG Team I-ORG Project I-ORG for I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG Resources I-ORG and I-ORG Ethnic I-ORG Medicine I-ORG of I-ORG Dali I-ORG University I-ORG ZKLX2019318 O This O work O is O supported O by O Consejo B-ORG Nacional I-ORG de I-ORG Investigaciones I-ORG Científicas I-ORG y I-ORG Técnicas I-ORG Universidad I-ORG Nacional I-ORG de I-ORG Río I-ORG Cuarto I-ORG Universidad I-ORG Nacional I-ORG del I-ORG Sur I-ORG PGI O 24/Q074 O Agencia B-ORG Nacional I-ORG de I-ORG Promoción I-ORG Científica I-ORG y I-ORG Técnica I-ORG PICT-2015-2151 O and I-AWARD PICT-2015-0585 O and O Ministerio B-ORG de I-ORG Industria I-ORG Comercio I-ORG Minería I-ORG y I-ORG Desarrollo I-ORG Científico I-ORG Tecnológico I-ORG de I-ORG Córdoba I-ORG PID-2013 O This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC1304100 O the B-ORG National I-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81970045 O 81570035 O 41871029 O Provincial B-ORG Innovation I-ORG and I-ORG Research I-ORG Team I-ORG Project I-ORG 2017BT01S155 O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG 201504010018 O Study O funding O had O no O influence O on O the O study O This O study O was O financially O supported O by O the O Yangtze B-ORG River I-ORG Delta I-ORG joint I-ORG research I-ORG project I-ORG from O the O Shanghai O Science O and O Technology O Committee O 15595811000 O the O Open B-ORG Research I-ORG Funding I-ORG Program I-ORG of I-ORG KLGIS I-ORG KLGIS2015A06 O and O Key B-ORG Projects I-ORG in I-ORG the I-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG Pillar I-ORG Program I-ORG during I-ORG the I-ORG Thirteen I-ORG Five-year I-ORG Plan I-ORG Period I-ORG 2013BAD13B01 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O “13th O Five-Year” O National O Key O R&D O Plan O 2017YFD0600801 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.31901374 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20180774 O Jiangsu B-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Independent I-ORG Innovation I-ORG Project I-ORG CX(18)3033 O This O work O was O supported O by O the O International B-ORG Wheat I-ORG Yield I-ORG Partnership I-ORG IWYP O project B-AWARD 89) O through O grants O from O the O Grains B-ORG Research I-ORG and I-ORG Development I-ORG Corporation I-ORG GRDC O US00082 B-AWARD and O DAV00141 B-AWARD Additional O support O was O provided O by O the O GRDC O US00081 O the O Australian B-ORG Research I-ORG Council I-ORG DP150103863 O LP130100183 B-AWARD the O National B-ORG Science I-ORG Foundation I-ORG 1557906 O 1951244 B-AWARD and O the O USDA O National B-ORG Institute I-ORG of I-ORG Food I-ORG and I-ORG Agriculture O Hatch O project O 1016439 B-AWARD This O work O was O supported O by O the O European O Union’s O Horizon O 2020 O research O and O innovation O programme O under O the O European B-ORG Research I-ORG Council I-ORG ERC O Consolidator O grant O agreement O No. O 818521 B-AWARD M.T.d.S O DISCONNECTOME O and O the O Marie B-ORG Skłodowska-Curie I-ORG grant O agreement O No. O 101028551 B-AWARD S.J.F O PERSONALISED O and O the O Donders B-ORG Mohrmann I-ORG Fellowship O No. O 2401515 B-AWARD S.J.F O NEUROVARIABILITY O Additionally O this O work O was O conducted O in O the O framework O of O the O University O of O Bordeaux’s O IdEx O ‘Investments O for O the O Future’ O program O RRI O ‘IMPACT’ O which O received O financial O support O from O the O French O government O P.N O is O funded O by O the O Welcome O Trust O and O the O UCLH O NIHR O Biomedical O Research O Centre O V.P O is O funded O by O the O NextGenerationEU B-ORG PNRR I-ORG grant O No. O SOE_0000130 B-AWARD This O work O was O supported O by O a O Leverhulme B-ORG Trust I-ORG research O grant O ref O no. O RPG-2016-015 B-AWARD to O J.P.M O and O A.A.F O J.P.M O is O also O grateful O for O funding O from O the O Wellcome B-ORG Trust I-ORG 208375/Z/17/Z O and O the O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG BB/R014949/1 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31900388 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20191055 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Colleges I-ORG of I-ORG Jiangsu I-ORG Province I-ORG 19KJB180009 O This O work O was O supported O by O grants O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2017YFA0106700 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31 O 771 I-AWARD 462 O 81 B-AWARD 772 I-AWARD 614 O 31 B-AWARD 471 I-AWARD 252 O 31 B-AWARD 500 I-AWARD 813 O 91 B-AWARD 753 I-AWARD 137 I-AWARD and O U1611261 B-AWARD Guangdong B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2014TQ01R387 O 2014A030313181 B-AWARD and O 2017A030313134 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017M622864 O Fundamental O Research O Funds O for O the O Central O Universities O No. O 17lgpy106 O This O work O was O supported O via O a O Wellcome B-ORG Trust I-ORG New O Investigator O award O to O L.J.H O 100974/Z/13/Z O a O Wellcome O Trust O grant O awarded O to O A.J.M.W O WT0087768MA O support O of O the O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG BBSRC O Institute O Strategic O Programme O grant O for O Gut O Health O and O Food O Safety O BB/J004529/1 B-AWARD L.J.H O and O A.J.M.W O and O Science B-ORG Foundation I-ORG Ireland I-ORG through O the O Irish O Government's O National O Development O Plan O grant O number O SFI/12/RC/2273 B-AWARD D.v.S O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Key O Program O No. O 31330067 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG of I-ORG Tangshan I-ORG City I-ORG grant O no. I-AWARD 15120204a O and O the O Shanghai B-ORG ‘2011’ I-ORG program I-ORG no. O ZF12051301 B-AWARD Analysis O of O elemental O composition O and O expression O of O genes O of O metal O detoxification O were O supported O by O the O Tomsk B-ORG State I-ORG University I-ORG Development I-ORG program I-ORG Priority-2030 O project O no. O 2.1.2.22 B-AWARD Physiological O analyses O were O supported O by O the O Russian B-ORG Science I-ORG Foundation I-ORG project O no. O 23-44-10019 B-AWARD Analysis O of O primary O photosynthetic O processes O was O supported O by O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Higher I-ORG Education I-ORG of I-ORG the I-ORG Russian I-ORG Federation I-ORG project O No. O 122042700044-6 B-AWARD Determination O of O the O endogenous O content O of O brassinosteroids O was O performed O with O the O financial O support O by O the O Belarusian B-ORG Republican I-ORG Foundation I-ORG for I-ORG Fundamental I-ORG Research I-ORG project O no. O X23RSF-087 B-AWARD This O work O received O support O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U1805243 B-AWARD key B-ORG research I-ORG program I-ORG of I-ORG Frontier I-ORG Sciences I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences,Key I-ORG Laboratory I-ORG of I-ORG Drug I-ORG Research I-ORG CN) O QYZDBSSW B-AWARD DQC002-03 O Youth B-ORG Innovation I-ORG Promotion I-ORG Association I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG 2017239 B-AWARD Weidong O Zhang O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFA060080203 B-AWARD Weidong O Zhang O This O work O was O supported O by O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31271782 O the B-ORG earmarked I-ORG fund I-ORG for I-ORG the I-ORG Modern I-ORG Agriculture I-ORG Technology I-ORG of I-ORG China I-ORG CARS-20 O and O Scientific B-ORG Research I-ORG Fund I-ORG of I-ORG Fujian I-ORG Provincial I-ORG Education I-ORG Department I-ORG JA12124 O and O Science B-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG Fujian I-ORG Province I-ORG 2015NZ0002-2 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2022YFF1100103 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32072196 O and O the O 111 B-ORG Project I-ORG from I-ORG the I-ORG Education I-ORG Ministry I-ORG of I-ORG China I-ORG No. O B18053 B-AWARD This O work O is O financially O supported O by O the O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG CIFMS O Grant O number O 2016-I2M-1-002 B-AWARD the O Beijing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG Grant O number O Z151100003915078 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O number O 2016ZX310177 B-AWARD The O study O was O supported O by O the O “Innovation O Training I-ORG Project I-ORG from I-ORG SCU I-ORG Training I-ORG Programs I-ORG of I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG for I-ORG Undergraduates” O C2020107885 O the O “Research O of I-ORG Graduate I-ORG Education I-ORG Reform I-ORG of I-ORG Sichuan I-ORG University I-ORG 2019)” O Nos O YJSJG006 B-AWARD and O the O “Sichuan O Science I-ORG Popularization I-ORG Project” O 2020JDKP0018 O The O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31672658 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Ningbo I-ORG 2017C110001 O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG LY18C030002 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Ningbo I-ORG University I-ORG XYL17023 O and O K.C O Wong O Magna O Fund O in O Ningbo O University O This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.21406083 O and I-AWARD 31600047 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No.BK20150412 O Huai’an B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG No.HAG2015037 O and O Opening B-ORG Fund I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Engineering I-ORG Laboratory I-ORG for I-ORG Biomass I-ORG Conversion I-ORG and I-ORG Process I-ORG Integration I-ORG Huaiyin O Institute O of O Technology O JPELBCPI2015001 B-AWARD This O work O was O funded O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2022YFB3706903 B-AWARD the O Major B-ORG Project I-ORG of I-ORG Technological I-ORG Innovation I-ORG in I-ORG Hubei I-ORG Province I-ORG Grant O No. O 2020BED010 B-AWARD and O Grant O No. O 2022BAD108 B-AWARD the O Open B-ORG Fund I-ORG of I-ORG Hubei I-ORG Longzhong I-ORG Laboratory I-ORG Grant O No. O 2022ZZ-28 B-AWARD and O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2020M682498 B-AWARD This O work O was O partially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O No. O 81871424 B-AWARD and O No. O 81901698 B-AWARD National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG under O Grant O No. O 2017YFC0107400 B-AWARD Shaanxi B-ORG Research I-ORG and I-ORG development I-ORG plan I-ORG under O Grant O No. O 2016 B-AWARD MSZD-S-2-5 I-AWARD This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O no. O 81600624 B-AWARD no. O 81673792 B-AWARD no. O 81704134 B-AWARD no. O 81873346 B-AWARD no. O U1801288 B-AWARD and O no. O 81900607 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG no. O 2017A030313708 B-AWARD Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG no. O 2017A020215158 B-AWARD and O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangzhou I-ORG China I-ORG no. O 201707010286 B-AWARD No O funders O had O a O role O in O the O design O of O the O study O data O collection O analysis O and O data O interpretation O or O writing O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31751001 O 41967013 O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG during I-ORG the I-ORG Twelfth I-ORG Five-year I-ORG Plan I-ORG Period I-ORG 2015BAD22B01 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 2018JQ3053 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O 81672275 I-AWARD and I-AWARD 81874052 O Project B-ORG of I-ORG Jilin I-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG Grant O JJKH20190020KJ O Project B-ORG of I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Jilin I-ORG Province I-ORG Grants O 20180101009JC I-AWARD and I-AWARD 20190303146SF O Ths O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 81502119 B-AWARD to O Fang O Liu O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG no. O 2015A030310109 B-AWARD to O Fang O Liu O Medical B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O China O no. O A2015289 B-AWARD to O Qinghua O Cao O This O work O was O supported O by O National B-ORG Key I-ORG Clinical I-ORG Discipline I-ORG the I-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG young I-ORG teacher I-ORG training I-ORG program I-ORG of I-ORG Sun I-ORG Yat-sen I-ORG University I-ORG grant O number O 18ykpy02 B-AWARD Medical B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG of I-ORG China I-ORG grant O number O A2016198 B-AWARD and O ‘5010 O Clinical B-ORG Research I-ORG Programme’ I-ORG of I-ORG Sun I-ORG Yat-sen I-ORG University I-ORG grant O number O 2010012 B-AWARD This O work O was O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG G00009988 O to O TNFR O OCE-0927415 B-AWARD to O LWK O and O OISE-1243541 B-AWARD to O FR O the O Gordon B-ORG and I-ORG Betty I-ORG Moore I-ORG Foundation I-ORG GBMF3781 O to O FR O the O Canadian B-ORG Institute I-ORG for I-ORG Advanced I-ORG Research I-ORG CIFAR I-ORG CIFAR162307 O to O FR O and O the O Pew B-ORG Foundation I-ORG PROJ28972 O to O FR O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Deutsche B-ORG Forschungsgemeinschaft[SFB O 829 I-AWARD to I-AWARD M.H O theEuropean O Union I-ORG Seventh I-ORG Framework I-ORG Program I-ORG HEALTH-F4-2010-242048 B-AWARD to I-AWARD M.H O and O theNational O Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG GM63904 B-AWARD to I-AWARD M.H O RR O is O supported O by O a O BHF O Intermediate O Basic O Science O Research O Fellowship O FS/15/2/31225 O This O work O was O supported O by O the O National B-ORG Research I-ORG Foundation I-ORG Grant O no: O 118160 B-AWARD and O no: O 138089 B-AWARD Additionally O this O work O is O based O on O the O research O supported O by O the O University B-ORG of I-ORG the I-ORG Western I-ORG Cape’s I-ORG School I-ORG of I-ORG Public I-ORG Health I-ORG and I-ORG The I-ORG Belgian I-ORG Directorate-General I-ORG for I-ORG Development I-ORG Cooperation O through O its O Framework O Agreement O with O the O Institute O for O Tropical O Medicine O Grant O Ref O FA4 B-AWARD DGD-ITM I-AWARD 2017–2020 O Additional O funding O was O received O from O the O Oppenheimer B-ORG Memorial I-ORG Trust I-ORG OMT20829/02 O This O work O was O supported O by O theEuropean O Research I-ORG CouncilAdvanced O Grant O grant O number O PBDR B-AWARD 268540 O theSwiss O National I-ORG Science I-ORG Foundation[grant O number O P2EZP3_162257 B-AWARD and O SystemsX O the O Swiss O Initiative O forSystems O Biology[grant O number O 51FSP0_163566 B-AWARD F.F O would O like O to O acknowledge O the O NIH O COBRE O Program(grant O no. O 1P20GM130454 O and O theBill O I-ORG Melinda I-ORG Gates I-ORG Foundation(award O no. O OPP1217336 B-AWARD for O generous O financial O support O This O work O has O been O supported O by O the O Foundation O for O Scientific O Research O of O Flanders O FWO-Vlaanderen O and O the O Geconcerteerde B-ORG Onderzoeksacties I-ORG GOA O 2013/014 I-AWARD and O C1 B-AWARD 2017-2023 O of O the O research O fund O of O the O KU O Leuven-University O of O Leuven O PVDS O is O a O research O professor O at O the O KU O Leuven O Additional O support O comes O from O the O MIUR-PRIN B-ORG project I-ORG 20154JRJPP_004 B-AWARD to O DT. O This O work O was O supported O by O the O Key B-ORG Project I-ORG of I-ORG the I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2020KB021 O the O Key B-ORG R&D I-ORG Program I-ORG of I-ORG Shandong I-ORG province I-ORG 2020CXGC010703 O and O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2019YFD0900505 O This O work O was O supported O by O grants O from O the O Chung B-ORG Shan I-ORG Medical I-ORG University I-ORG Hospital I-ORG grant O number O CSH-2022-C-013 B-AWARD China B-ORG Medical I-ORG University I-ORG grant O number O CMU111-S-30 B-AWARD and O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG grant O number O MOST B-AWARD 109-2314-B-040-009-MY3 O in O Taiwan O This O study O was O funded O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFF0202303 O National B-ORG Key I-ORG Scientific I-ORG Instrument I-ORG and I-ORG Equipment I-ORG Project I-ORG of I-ORG NSFC I-ORG 21627812 O General B-ORG Program I-ORG of I-ORG NSFC I-ORG 21676156 O Tsinghua B-ORG University I-ORG Initiative I-ORG Scientific I-ORG Research I-ORG Program I-ORG 20161080108 O This O study O was O funded O by O theNational O Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China(grant O No. O 81171283 B-AWARD theNational O Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG of I-ORG China(grant O No. O 2016YFC0107101 B-AWARD and O theInnovative O Talents I-ORG Project I-ORG of I-ORG Southwest I-ORG Hospital(grant O No. O SWH2015QN12 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31370125 B-AWARD the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG 2018ZX09735001-002-002 O and O Liaoning B-ORG Outstanding I-ORG Science I-ORG and I-ORG Technology I-ORG Talent I-ORG LR2015065 O This O research O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81201609 O 81401767 B-AWARD the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0903503 O and O Sichuan B-ORG Youth I-ORG Science I-ORG and I-ORG Technology I-ORG 2016JQ0053 O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 81400828 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2014HQ057 O This O study O was O also O supported O by O Projects O of O the O Medical B-ORG and I-ORG Health I-ORG Technology I-ORG Development I-ORG Program I-ORG in I-ORG Shandong I-ORG Province I-ORG 2016WS0427 O and O Shandong B-ORG Key I-ORG R&D I-ORG Program I-ORG 2017GSF18129 O This O research O was O funded O by O the O Program O of O Study O Abroad O for O Young O Scholar O sponsored O by O CSC O China O Scholarship O Council O grant O number O 201906565024 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 51301021 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation O grant O number O 2016M592730 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities O grant O numbers O 300102318205 O 310831161020 B-AWARD 310831163401 B-AWARD 300102319304 B-AWARD the O Innovation O and O Entrepreneurship O Training O Program O of O Chang’ O an O University O grant O number O 201910710144 O the O Key O projects O of O Shaanxi O Natural O Science O Foundation O grant O number O 2019JZ-27 O the O Shaanxi O Natural O Science O Basic O Research O Program-Shaanxi O Coal O grant O number O 2019JLM-47 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grants O 32293243 B-AWARD National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2021YFD1401000 O and O the O 111 B-ORG Project I-ORG from O the O Ministry O of O Education O of O China O BP0719026 O This O work O was O supported O by O the O Research B-ORG Council I-ORG in I-ORG Southeast I-ORG Sweden I-ORG grant O number O FORSS*660371 B-AWARD Swedish B-ORG Research I-ORG Council I-ORG grant O number O 2017*01444 B-AWARD and O Region B-ORG of I-ORG Östergötland I-ORG grant O number O LIO-817751 B-AWARD LIO-922501 B-AWARD The O funding O bodies O had O no O role O in O the O design O or O conduct O of O the O study O the O collection O analysis O or O interpretation O of O data O in O writing O or O in O the O decision O to O submit O the O manuscript O for O publication O Open O access O funding O provided O by O Linköping O University O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31660353 O the O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0101900 B-AWARD the O Genetically B-ORG Modified I-ORG Organisms I-ORG Breeding I-ORG Major I-ORG Project I-ORG of I-ORG China I-ORG Grant B-AWARD No.2016ZX08005–005 O and O the O specific B-ORG Project I-ORG for I-ORG Crops I-ORG Breeding I-ORG of I-ORG Shihezi I-ORG University I-ORG YZZX201601 B-AWARD The O funding O bodies O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O We O acknowledge O the O financial O support O of O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O Grant O No. O 21706005 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2017M610747 B-AWARD and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O ZY1713 B-AWARD This O study O was O supported O in O part O by O grant O number O 81370520 B-AWARD from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O by O the O Grant O for O Clinical O Research O number O BE2015655 B-AWARD from O the O Department B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Jiangsu I-ORG Province I-ORG China O by O grant O number O BK2012653 B-AWARD from O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG China O by O the O Young O Investigator O Grant O number O Q201208 B-AWARD from O the O Department B-ORG of I-ORG Health I-ORG Jiangsu I-ORG Province I-ORG China O and O by O grant O number O MS12015004 B-AWARD from O the O Nantong B-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG Jiangsu I-ORG Province I-ORG China O The O funding O agreement O ensured O the O authors’ O independence O in O designing O the O study O interpreting O the O data O writing O and O publishing O the O report O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 22179035 O and O 21901065 B-AWARD the O Science B-ORG Fund I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG JQ2022B001 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG LH2020B019 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG Youth I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Team I-ORG Project I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG 2021-KYYWF-0030 O and O the O Postdoctoral B-ORG Science I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG Grant O LBH-Z19198 B-AWARD This O work O was O supported O by O Zhejiang B-ORG Medical I-ORG and I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG Number O 2022KY886 B-AWARD Wenzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG Number O Y2020010 B-AWARD and O Wenzhou B-ORG Medical I-ORG University I-ORG Research I-ORG Project I-ORG Number O wyx2021101045 B-AWARD This O work O was O supported O by O the O Key B-ORG Project I-ORG of I-ORG Hebei I-ORG North I-ORG University I-ORG No. O 120177 B-AWARD science B-ORG and I-ORG technology I-ORG bureau I-ORG research I-ORG development I-ORG plan I-ORG of I-ORG zhangjiakou I-ORG city I-ORG in I-ORG Hebei I-ORG No. O 0911021D-4 O and O the B-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Project I-ORG of I-ORG Hebei I-ORG Province I-ORG Department I-ORG Institutions I-ORG of I-ORG Higher I-ORG Learning I-ORG No. O Z2015047 O China O This O paper O is O supported O by O grants O from O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 81873452 B-AWARD and O 81400147 B-AWARD Wuhan B-ORG Huanghe I-ORG Yingcai I-ORG Technology I-ORG Project I-ORG HHYC-2015002 O and O Applied B-ORG Basic I-ORG Research I-ORG Project I-ORG of I-ORG Wuhan I-ORG City I-ORG No. O 2017060201010156 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21706148 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2020ME041 O ZR2022QB173 B-AWARD Joint B-ORG Zibo–SDUT I-ORG Fund I-ORG 2019ZBXC358 O and O the O Foundation B-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Biobased I-ORG Material I-ORG and I-ORG Green I-ORG Papermaking I-ORG Qilu I-ORG University I-ORG of I-ORG Technology I-ORG Shandong I-ORG Academy I-ORG of I-ORG Sciences I-ORG KF2019–06 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 32001689 B-AWARD the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG in I-ORG Guangdong I-ORG Province I-ORG of I-ORG China I-ORG grant O number O 2022B0202050001 B-AWARD the O Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG for I-ORG Chinese I-ORG Academy I-ORG of I-ORG Tropical I-ORG Agricultural I-ORG Sciences I-ORG grant O number O 1630122022005 B-AWARD and O Innovative B-ORG and I-ORG Entrepreneurship I-ORG Team I-ORG Project I-ORG for I-ORG “Pilot I-ORG Program” I-ORG of I-ORG Zhanjiang I-ORG City I-ORG grant O number O 211207157080998 B-AWARD The O project O was O supported O by O Grant O R01AR059142 B-AWARD from O National B-ORG Institute I-ORG of I-ORG Arthritis I-ORG and I-ORG Musculoskeletal I-ORG and I-ORG Skin I-ORG Diseases I-ORG US O P20GM104937 B-AWARD from O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG US O and O 81572098 B-AWARD from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O by O the O Key B-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG ZDRW-CN-2021-2-2 O the O Self-deployed B-ORG Projects I-ORG of I-ORG Ganjiang I-ORG Innovation I-ORG Academy I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG E155D001 O the O Projects O of O the O Innovation B-ORG Academy I-ORG for I-ORG Green I-ORG Manufacture I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG IAGM O 2020DB04 O and O the O Double B-ORG Thousand I-ORG Plan I-ORG of I-ORG Jiangxi I-ORG Province I-ORG jxsq2020105012 O This O work O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81571750 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2014A030311018 O 2014A030310484 B-AWARD 2015A030313043 B-AWARD S&T O Programs O 2014A020212125 O of O Guangdong O Province O Medical B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG A2013196 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG grant O numbers O 8227060392 B-AWARD Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG 2020B1515020001 O and O the O GDPH B-ORG supporting I-ORG fund I-ORG KY012021439)(X.Z O and O Social B-ORG Development I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Dongguan I-ORG 20211800904742)(Y.S O This O work O has O been O granted O by O “Acción O Estratégica I-ORG en I-ORG Salud I-ORG del I-ORG Ministro I-ORG de I-ORG Ciencia I-ORG e I-ORG Innovación” O DPS2008-07033-C03-03 O Programme O of O Promotion O of O Biomedical O Research O and O Health O Sciences O Projects O 11/01791 O Red B-ORG Predimed-RETIC I-ORG RD06/0045/1004 B-AWARD CIBERobn B-ORG CB12/03/30038 B-AWARD Balearic O Island O Government O and O FEDER O funds O 35/2011 O and O 23/2012 O PROMETEO/2012/007 B-AWARD from O Generalitat B-ORG Valenciana I-ORG to O ER. O ER O is O recipient O of O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III-FEDER O PS09/01093 O and O Fundacion O Salud O 2000-Merck O Serono O grants O LC-Q O was O recipient O of O a O CONACYT-Mexico B-ORG ref O 197139 B-AWARD fellowship O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81473261 O to O Z.H O Key O Project O from O Science B-ORG Technology I-ORG Department I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2017C030330 O and O Wenzhou O ZS2017013 O to O Z.H O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG LY15H300004 O to O J.N O and O LQ15H310005 B-AWARD to O L.S O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Wenzhou I-ORG Y20140724 O Y20140734 B-AWARD Y20160163 B-AWARD This O work O was O supported O by O the O following O foundations O The O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O No. O 61501153 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Provincial I-ORG Universities I-ORG of I-ORG Zhejiang O Grant O No. O GK219909299001-024 B-AWARD and O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O No. O LQ22F010014 B-AWARD Gipuzkoa O This O study O was O funded O by O grants O from O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III I-ORG FIS-PI06/0867 O FIS-PI09/00090 I-AWARD and I-AWARD FIS-PI13/02187 O CIBERESP O Department B-ORG of I-ORG Health I-ORG of I-ORG the I-ORG Basque I-ORG Government I-ORG 2005111093 O 2009111069 I-AWARD and I-AWARD 2013111089 O and O the O Provincial O Government O of O Gipuzkoa O DFG06/002 O and I-AWARD DFG08/001).Sabadell O This O study O was O funded O by O grants O from O Instituto O de O Salud O Carlos O III O Red O INMA I-AWARD G03/176 B-AWARD CB06/02/0041 B-AWARD PI041436 B-AWARD and B-AWARD PI081151 I-AWARD including I-AWARD support I-AWARD from I-AWARD the I-AWARD European I-AWARD Regional I-AWARD Development I-AWARD Fund I-AWARD ERDF O Generalitat B-ORG de I-ORG Catalunya-CIRIT O 1999SGR B-AWARD 00241 O Fundació B-ORG La I-ORG marató I-ORG de I-ORG TV3 I-ORG 090430 O ISGlobal O is O a O member O of O the O CERCA B-AWARD Programme O Generalitat O de O Catalunya.Valencia:This O study O was O funded O by O grants O from O the O European B-ORG Union I-ORG FP7-ENV-2011 O grant I-AWARD number I-AWARD 282957 I-AWARD and I-AWARD HEALTH.2010.2.4.5-1 O Spain O ISCIII O G03/176 O FIS-ERDF B-AWARD PI11/01007 I-AWARD PI11/02591 I-AWARD PI11/02038 I-AWARD PI12/00610 I-AWARD PI13/1944 I-AWARD PI13/2032 I-AWARD PI14/00891 I-AWARD PI14/01687 I-AWARD PI16/1288 I-AWARD and I-AWARD PI17/00663 O Miguel B-AWARD Servet-European I-AWARD Regional I-AWARD Development I-AWARD Fund I-AWARD CP11/00178 I-AWARD CP15/00025 I-AWARD and I-AWARD MSII16/00051 O Generalitat O Valenciana O FISABIO O UGP O 15-230 I-AWARD UGP-15-244 I-AWARD and I-AWARD UGP-15-249 O and O the O Alicia B-ORG Koplowitz I-ORG Foundation I-ORG 2017 O Instituto O de O Salud O Carlos O III O through O the O projects O “CP14/00108 O and O PI16/00261” O Co-funded O by O European O Regional O Development O Fund O “A O way O to O make O Europe” O Jordi O Julvez O holds O the O Miguel O Servet-II O contract O CPII19/00015 O awarded O by O the O Instituto O de O Salud O Carlos O III O co-funded O by O the O European O Social O Fund O “Investing O in O your O future” O All O authors O are O grateful O for O the O support O by O the B-ORG State I-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81371957 O the B-ORG State I-ORG Key I-ORG Program I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81330042 O the B-ORG Special I-ORG Program I-ORG for I-ORG Sino-Russian I-ORG Joint I-ORG Research I-ORG sponsored I-ORG by I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG China I-ORG 2014DFR31210 O and O the B-ORG Key I-ORG Program I-ORG sponsored I-ORG by I-ORG the I-ORG Tianjin I-ORG Science I-ORG and I-ORG Technology I-ORG Committee I-ORG China I-ORG 13RCGFSY19000 O 14ZCZDSY00044 O This O study O was O supported O by O a O financial O agreement O between O Impulsora B-ORG Agriícola I-ORG S.A I-ORG de I-ORG C.V I-ORG and O Universidad O Nacional O Autónoma O de O México O UNAM O 36372-2821-14-XI-13 B-AWARD The O agreement O was O subscribed O to O fulfill O major O needs O for O scientific O contributions O in O the O field O of O Mexican O barley O breeding O Impulsora O Agricola O S.A O de O C.V O provided O the O biological O material O subject O of O research O and O financial O support O for O the O reserach O The O agreement O included O allowance O to O publish O the O results O elsewhere O Other O results O obtained O under O this O agreement O were O previously O published O and O cited O in O the O manuscript O 15. O Salgado-Albarrán O M, O Herrera-Díaz O J, O Dinkova O TD. O Caracterización O de O patrones O de O Hordeínas O en O variedades O mexicanas O de O cebada O maltera O Tip O Rev O Espec O en O Ciencias O Químico-Biológicas O 2015 O 18: O 43–51 O This O paper O has O online O access O The O manuscript O also O acknowledges O funding O by O Consejo B-ORG Nacional I-ORG de I-ORG Ciencia I-ORG y I-ORG Tecnología I-ORG CONACYT O 238439 B-AWARD Programa B-ORG de I-ORG Apoyo I-ORG a I-ORG Proyectos I-ORG de I-ORG Investigación I-ORG e I-ORG Innovación I-ORG Tecnológica I-ORG PAPIIT O IN O 214118 B-AWARD and O Programa O de O Apoyo O a O la O Investigación O y O Posgrado O PAIP O 5000-9118 O which O contributed O with O equipment O services O and O materials O This O research O is O partially O funded O by O Cancer B-ORG Research I-ORG UK I-ORG grant O number O C569/A16891 B-AWARD This O work O was O supported O by O the O National O Institute O for O Health O Research O NIHR O under O its O Programme B-ORG Grants I-ORG for I-ORG Applied I-ORG Research I-ORG programme O reference O number O RP-PG-0707-10031 B-AWARD “Improvement O in O risk O prediction O early O detection O and O prevention O of O breast O cancer” O and O the O Genesis B-ORG Prevention I-ORG Appeal I-ORG references O GA10-033 B-AWARD and I-AWARD GA13-006 O The O views O expressed O are O those O of O the O author(s O and O not O necessarily O those O of O Cancer O Research O UK, O the O National O Health O Service O NHS O the O NIHR O or O the O Department O of O Health O ROS O is O supported O by O the O Wellcome B-ORG Trust I-ORG grant O no. O 108861/7/15/7 B-AWARD and O the O Wellcome O Centre O for O Human O Genetics O grant O no. O 203141/7/16/7 O ARAA O and O CG O were O supported O by O the O U54CA143970 B-AWARD grant O from O the O US O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH O National O Cancer O Institute O NCI O EL O and O TAG O was O supported O by O Cancer B-ORG Research I-ORG UK I-ORG grant O no. O A19771 B-AWARD No O funding O body O played O a O role O in O the O design O of O the O study O analysis O and O interpretation O of O data O or O in O writing O the O manuscript O This O work O was O financially O supported O by O the B-ORG National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31701473 O 31601344 B-AWARD the B-ORG National I-ORG Key I-ORG R I-ORG I-ORG D I-ORG Project I-ORG for I-ORG Crop I-ORG Breeding I-ORG 2016YFD0101006 O and O the B-ORG 111 I-ORG project I-ORG of I-ORG China I-ORG D16014 O The O funding O bodies O did O not O play O a O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O but O just O provide O the O financial O support O This O project O was O supported O by O grants O from O The B-ORG National I-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81972806 O Jiangsu B-ORG Provincial I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG BE2019614 O Key B-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG of I-ORG Nanjing I-ORG Medicine I-ORG ZDX16001 O to O SKW O Innovation B-ORG team I-ORG of I-ORG Jiangsu I-ORG provincial I-ORG health-strengthening I-ORG engineering I-ORG by I-ORG science I-ORG and I-ORG education I-ORG CXTDB2017008 O Jiangsu B-ORG Youth I-ORG Medical I-ORG Talents I-ORG Training I-ORG Project I-ORG to O BSH O QNRC2016066 O and O YQP O QNRC2016074 O This O work O was O partially O supported O by O the O Vlaamse B-ORG Interuniversitaire I-ORG Raad I-ORG VLIR)-Belgium/Ministerio I-ORG de I-ORG Educación I-ORG Superior I-ORG MES)-Cuba O Project O CU2018TEA457A103 B-AWARD and O by O project O PN223LH010-035 B-AWARD from O the O Ministerio B-ORG de I-ORG Ciencia I-ORG Tecnología I-ORG y I-ORG Medio I-ORG Ambiente I-ORG Cuba O Programa O de O Ciencias O Básicas O y O Naturales O Research O in O the O Vandenabeele O unit O is O supported O by O grants O from O the O FWO B-ORG research O grants O G.0C76.18N B-AWARD G.0B71.18N B-AWARD G.0B96.20N B-AWARD G.0A93.22N B-AWARD EOS O MODEL-IDI O Grant O 30826052 O and O EOS O CD-INFLADIS O 40007512 O grants O from O the O Special B-ORG Research I-ORG Fund I-ORG UGent I-ORG Methusalem O grant O BOF16/MET_V/007 B-AWARD and O iBOF O ATLANTIS O grant O 20/IBF/039 B-AWARD and O grants O from O the O Foundation B-ORG against I-ORG Cancer I-ORG F/2016/865 O F/2020/1505 B-AWARD the O CRIG O and O GIGG O consortia O and O VIB O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31902078 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2662017QD036 O and O the O Open B-ORG Fund I-ORG of I-ORG Henan I-ORG Key I-ORG Laboratory I-ORG of I-ORG Tea I-ORG Plant I-ORG Comprehensive I-ORG Utilization I-ORG in I-ORG South I-ORG Henan I-ORG HNKLTOF2018003 O The O funders O had O no O role O in O the O experiment O design O data O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O Swedish B-ORG Research I-ORG Council I-ORG 2021-01439 O the O Heart-Lung B-ORG Foundation I-ORG 20220620 O 20220406 B-AWARD and O by O grants O from O the O Swedish B-ORG state I-ORG under I-ORG the I-ORG agreement I-ORG between O the O Swedish O government O and O the O county O councils O the O ALF-agreement O ALFGBG-965996 O This O work O was O funded O by O a O JSPS B-ORG Grant-in-Aid I-ORG for I-ORG Challenging I-ORG Exploratory I-ORG Research I-ORG no. O 16K14099 B-AWARD This O work O was O partially O supported O by O a O JSPS B-ORG Grant-in-Aid I-ORG for I-ORG Scientific I-ORG Research I-ORG B) O no. O 20H02202 B-AWARD and O a O Grant-in-Aid B-ORG for I-ORG Scientific I-ORG Research I-ORG on I-ORG Innovative I-ORG Areas I-ORG no. O 19H05789 B-AWARD This O work O was O supported O by O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG 2018ZX10101004 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81372043 B-AWARD the O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 7162199 B-AWARD and O TECHPOOL B-ORG Research I-ORG Fund I-ORG No. O 01201113 B-AWARD The O funders O have O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O Authors O would O like O to O acknowledge O the O financial O support O from O Deutscher O Akademischer O Austauschdienst O DAAD O and O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG CAPES O within O the O PROBRAL O project O PPP O Brasilien O Projektbezogener O Personenaustausch O Brasilien O V.C O Beber O acknowledges O the O funding O from O CAPES O Coordenação O de O Aperfeiçoamento O de O Pessoal O de O Nível O Superior O through O the O Science O without O Borders O program O under O the O grant O BEX O 13458/13-2 O K. O Koschek O the O funding O from O the O Bundesministerium B-ORG für I-ORG Bildung I-ORG und I-ORG Forschung I-ORG BMBF O through O the O NanoMatFutur O award O DuroCycleFVK O 03XP0001 O and O L. O H. O de O Carvalho O the O funding O from O CNPq O Conselho O Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico O through O grants O 403622/2013-0 B-AWARD and O 306792/2016-8 B-AWARD This O work O was O supported O by O the O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG 973 I-ORG Program I-ORG of I-ORG China I-ORG 2012CB910700 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O 81330054 O and O 31171362 B-AWARD to O Z.-X O X. O and O 31350110216 O to O J.B O NIH B-ORG Grants O CA79804 O to O Z-X O X., O and O AG31736 B-AWARD Project O 4) O and O AG13925 B-AWARD to O J.L.K O This O research O was O supported O by O the O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health I-ORG grant O number O R01-MH108729 B-AWARD the O National B-ORG Science I-ORG Foundation I-ORG grant O numbers O IOB-0522220 B-AWARD and O IOB-1146334 B-AWARD and O the O Defense B-ORG Advanced I-ORG Research I-ORG Projects I-ORG Agency I-ORG grant O number O N66001-10-C-2010 B-AWARD The O research O leading O to O these O results O has O received O funding O from O the O European O Union O Seventh B-ORG Framework I-ORG Programme I-ORG FP7/2007-2013 O under O grant O agreement O 317040 B-AWARD QuanTI O BA O is O a O Wellcome B-ORG Trust I-ORG Investigator O 103865 O and O is O funded O by O the O Medical B-ORG Research I-ORG Council I-ORG UK O J007439 O and O G1001052 B-AWARD the O European O Union O Seventh O Framework O Programme O FP7/2007–2013 O under O grant O agreement O 317040 O QuanTI O and O Leukemia B-ORG and I-ORG Lymphoma I-ORG Research I-ORG 15012 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O JL-B O is O funded O by O the O European O Union O Seventh O Framework O Programme O FP7/2007–2013 O under O grant O agreement O 317040 O QuanTI O This O study O was O supported O by O funding O from O the O Shanghai B-ORG Sailing I-ORG Program I-ORG 16YF1401100 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81802596 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG 17ZR1403500 O This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0501201 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2015A030312005 O the O Science O and O Technology O Program O of O Guangzhou O 201804020067 O and O the O Department B-ORG of I-ORG Education I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017KCXTD001 O 2018KZDXM015 B-AWARD This O study O was O supported O by O grants O from O GlaxoSmithKline B-ORG L100018639 O Wellcome B-ORG Trust I-ORG #092851 O and O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG BB/L502261 O This O work O was O funded O by O The O Victorian O Government’s O Operational O Infrastructure O Support O Program O Murdoch O Children’s O Research O Institute O Royal O Children’s O Hospital O Foundation O Martin O O E.H O Flack O Trust O Pierce O Armstrong O Trust O Financial B-ORG Markets I-ORG Foundation I-ORG for I-ORG Children I-ORG Australia O FMFC O grant O number O 2017-361 B-AWARD and O the O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG NHMRC O project O grant O numbers O 1049299 B-AWARD and O 1103389 B-AWARD D.E.G O was O supported O by O the O Next O Generation O Clinical O Researchers O Program—Career O Development O Fellowship O Funded O by O the O Medical B-ORG Research I-ORG Future I-ORG Fund I-ORG grant O number O 1141334 B-AWARD M.A O was O supported O by O the O International O Postgraduate O Research O Scholarship O IPRS O and O the O Research O Training O Program O Fee O offset O scholarship O funded O by O the O Australian O Government O and O awarded O by O the O University O of O Melbourne O and O in O part O by O the O Diagnosis O and O Development O group O of O the O Murdoch O Children’s O Research O Institute O H.L.W O would O like O to O highlight O that O this O material O is O based O upon O work O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG under O CHE-1464946 B-AWARD Additionally O research O reported O in O this O publication O was O supported O by O NIGMS O of O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG under O award O number O R01GM129519 B-AWARD F.L.K O acknowledges O funding O support O from O NSF’s O Graduate O Research O Fellowship O Program O project O number O 3900101301 B-AWARD Finally O F.L.K O L.W O and O H.L.W O would O like O recognize O that O additional O computational O support O was O provided O through O collaboration O with O University O of O South O Florida’s O Computing O Cluster O CIRCE O team O via O the O Major O Research O Instrumentation O Program O MRI-1531590 O Finally O S.B O gratefully O acknowledges O support O for O this O work O from O the O Austrian B-ORG Science I-ORG Fund/FWF O P31024 O The O study O was O supported O by O the O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 81501425 B-AWARD the B-ORG Science I-ORG and I-ORG technology I-ORG project I-ORG of I-ORG Suzhou I-ORG no. O SLT201921 B-AWARD and O the B-ORG Science I-ORG and I-ORG technology I-ORG project I-ORG of I-ORG Changzhou I-ORG no. O QN201926 B-AWARD and O Project B-ORG of I-ORG Changzhou I-ORG No.2 I-ORG People's I-ORG Hospital I-ORG no. O 2019K007 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31801993 B-AWARD the O China B-ORG Scholarship I-ORG Council I-ORG 202106875010 O and O 202106875013 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG China I-ORG Grant O No. O 2020JM-270 B-AWARD the O Postdoctoral B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG China I-ORG Grant O No. O 2017BSHEDZZ99 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG China I-ORG Grant O No. O GK202003052 B-AWARD and O GK202103068 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG NHMRC O funded O Centre O of O Research O Excellence O CRE O in O Targeted O Approaches O To O Improve O Cancer O Services O for O Aboriginal O and O Torres O Strait O Islander O Australians O TACTICS O 1153027 B-AWARD The O views O expressed O in O this O publication O are O those O of O the O authors O and O do O not O necessarily O reflect O the O views O of O the O funders O TB O was O supported O by O an O Australian B-ORG Research I-ORG Council I-ORG Discovery I-ORG Australian I-ORG Aboriginal I-ORG and I-ORG Torres I-ORG Strait I-ORG Islander I-ORG Award I-ORG #IN190100050 O and O a O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG Investigator I-ORG Grant O #2008097 O BS O was O funded O by O the O NSW B-ORG Government I-ORG through O a O Cancer O Institute O NSW O Career O Development O Fellowship O #2021/DCF1138 O BB O and O BM O were O partly O funded O by O TACTICS O #1153027 O GG O was O funded O by O a O NHMRC B-ORG Investigator I-ORG Grant O #1176651 O This O work O was O supported O by O The B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O nos I-AWARD 31701778 O to O JF, O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFE0101600 O to O JF, O The B-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG ASTIP O CAAS-ASTIP-2019-ZFRI-04 O to O JF, O and O Modern B-ORG agricultural I-ORG industry I-ORG technology I-ORG of I-ORG henan I-ORG province I-ORG S2014-11 O to O JF. O The O research O work O described O in O this O paper O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51538007 O 51778370 I-AWARD 51861165204 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2019B111107002 O 2017B030311004 O and O Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG JCYJ20170818094820689 O This O research O was O funded O by O Key-Area B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province O grant O number O 2019B020214003 B-AWARD Laboratory B-ORG of I-ORG Lingnan I-ORG Modern I-ORG Agriculture I-ORG Project O grant O number O NT2021009 B-AWARD Key-Area B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Guangzhou O grant O number O 202103000090 B-AWARD Key-Areas B-ORG of I-ORG Artificial I-ORG Intelligence I-ORG in I-ORG General I-ORG Colleges I-ORG and I-ORG Universities I-ORG of I-ORG Guangdong I-ORG Province O grant O number O 2019KZDZX1012 B-AWARD Royal B-ORG Society I-ORG International I-ORG Exchanges I-ORG programme I-ORG under O the O grant O No. O IEC\NSFC\191320 B-AWARD The B-ORG leading I-ORG talents I-ORG of I-ORG Guangdong I-ORG province I-ORG program O grant O number O 2016LJ06G689 B-AWARD China B-ORG Agriculture I-ORG Research I-ORG System O grant O number O CARS-15-23 B-AWARD and O The O 111 B-ORG Project O grant O number O D18019 B-AWARD The O authors’ O current O work O on O breast O cancer O lung O metastasis O is O funded O by O grants O from O the O U.S B-ORG Department I-ORG of I-ORG Defense I-ORG Breast O Cancer O Research O Program O grant O BC160912 O the O Cancer B-ORG Research I-ORG Society I-ORG grant O 22386 B-AWARD a O London O Regional O Cancer O Program O Catalyst O Grant O and O support O from O S. O and O R. O Shaftoe O through O the O London O Health O Sciences O Foundation O Both O B. O Medeiros O and O A. O Allan O are O supported O by O the O Breast B-ORG Cancer I-ORG Society I-ORG of I-ORG Canada I-ORG This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O under O Grant O number O 81274147 B-AWARD 81373513 B-AWARD the O National B-ORG TCM I-ORG Clinical I-ORG Research I-ORG Base I-ORG for O the O second O batch O of O business O research O projects O under O Grant O number O JDZX2015172 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG in O China O under O Grant O number O 2018CFC891 B-AWARD 2012FFC04601 B-AWARD This O research O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No: O 11872074 B-AWARD 82202821 B-AWARD 31900943 B-AWARD Beijing B-ORG Municipal I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O No: O L222138 B-AWARD Peking B-ORG University I-ORG Third I-ORG Hospital I-ORG Grant O No: O BYSYZHKC2022119 B-AWARD BYSY2022058 B-AWARD BYSYZD2021012 B-AWARD This O research O was O funded O by O the O Chinese B-ORG National I-ORG Science I-ORG Foundation I-ORG 42276122 O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2019YFD0900402 O the O Earmarked B-ORG Fund I-ORG CARS48 O and O the O Central B-ORG Public-Interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG CAFS I-ORG 2020TD46 O The O study O was O funded O by O the O Australian B-ORG National I-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG Project O Grant I-AWARD APP I-AWARD 1081320 O for O all O fieldwork O and O by O DECRA O grant O from O the O Australian B-ORG Research I-ORG Council I-ORG DE150101574 O and O the O Australian B-ORG Dental I-ORG Research I-ORG Foundation I-ORG grant O 136-2016 O for O laboratory O consumables O and O sequencing O This O study O was O supported O by O grants O from O the O Shanghai B-ORG Science I-ORG Committee I-ORG Foundation I-ORG no. O 34119b0600 B-AWARD no. O 16411970800 B-AWARD Shanghai B-ORG Municipal I-ORG Health I-ORG Bureau I-ORG no. O 20134194 B-AWARD Jiaxing B-ORG Science I-ORG Committee I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG province I-ORG no. O 2015AY23071 B-AWARD and O the O Technology B-ORG Plan I-ORG Project I-ORG of I-ORG Medicine I-ORG and I-ORG Health I-ORG in I-ORG Zhejiang I-ORG Province I-ORG no. O 2016KYB295 B-AWARD This O work O was O supported O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG Grant O R01GM095384-01 B-AWARD to I-AWARD F.R O Grants O NS047101 B-AWARD and I-AWARD R21AI094534 I-AWARD from O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences O and O the O Gordon B-ORG and I-ORG Betty I-ORG Moore I-ORG Foundation I-ORG Investigator O Award I-AWARD 3781 O J.J.B O received O funding O and O support O from O San O Diego O State O University O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O the O Medical B-ORG Research I-ORG Council I-ORG grant O MR/N010760/1 B-AWARD and O the O UK O National O Institute O for O Health O Research O NIHR O Health O Protection O Research O Unit O HPRU O in O Modelling O Methodology O at O Imperial O College O London O in O partnership O with O Public B-ORG Health I-ORG England I-ORG PHE O grant O HPRU-2012-10080 B-AWARD DJW O is O a O Sir O Henry O Dale O Fellow O jointly O funded O by O the O Wellcome O Trust O and O the O Royal B-ORG Society I-ORG grant O 101237/Z/13/Z B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32072206 O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2019YFD1002503 O and O the O China B-ORG Technology I-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-29-jg-3 O This O work O was O supported O by O grants O from O the B-ORG National I-ORG Special I-ORG Program I-ORG for I-ORG Scientific I-ORG Research I-ORG of I-ORG Public I-ORG Health I-ORG of I-ORG China I-ORG No. O 201302004 B-AWARD to O Y.S O No. O 201502021 B-AWARD to O J.C O the B-ORG Special I-ORG National I-ORG Project I-ORG on I-ORG Research I-ORG and I-ORG Development I-ORG of I-ORG Key I-ORG Biosafety I-ORG Technologies I-ORG of I-ORG China I-ORG No.2016YFC1201900 O to O J.C O the B-ORG Guangxi I-ORG Medical I-ORG and I-ORG Health I-ORG Topics I-ORG of I-ORG Self-financing I-ORG Scheme I-ORG No. O Z2014155 B-AWARD to O Z.J O and O the B-ORG Fourth I-ORG Round I-ORG of I-ORG Three-Year I-ORG Public I-ORG Health I-ORG Action I-ORG Plan I-ORG of I-ORG Shanghai I-ORG China I-ORG No. O 15GWZK0101 B-AWARD to O JC O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O work O was O supported O by O the O fundamental B-ORG scientific I-ORG research I-ORG program I-ORG on O the O project O 0310-2018-0010 O in O fluorescent O in O situ O hybridization O the O Russian B-ORG Science I-ORG Foundation I-ORG project O 14-14-00934 O for O works O on O comparison O of O cytological O and O physical O maps O of O theDrosophilafourth O chromosome O and O the O Russian B-ORG Foundation I-ORG for I-ORG Basic I-ORG Research I-ORG project O 17-00-00284 O regarding O software O development O and O definition O of O transposable O element O localization O in O cytological O structures O of O the O dot O chromosome O This O research O was O funded O by O supported O by O the O Key-Areas B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2020B020220008 O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0201006 O the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-04-PS09 O the O Guangdong B-ORG Agricultural I-ORG Research I-ORG System I-ORG 2019KJ136 O and O the O Research B-ORG Project I-ORG of I-ORG the I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Agricultural I-ORG and I-ORG Biological I-ORG Resources I-ORG Protection I-ORG and I-ORG Utilization I-ORG in I-ORG Subtropics I-ORG 4100-M13024 O The O funding O bodies O had O no O role O in O study O design O data O collection O analysis O and O interpretation O decision O to O publish O or O writing O of O the O manuscript O This O research O was O supported O by O a O postdoctoral O grant O from O the O Spanish B-ORG “Ministerio I-ORG de I-ORG Ciencia I-ORG Innovación I-ORG y I-ORG Universidades” I-ORG FJCI-2016-28405 O to O Antonio O Luque-Casado O predoctoral O grants O from O the O Spanish B-ORG Ministerio I-ORG de I-ORG Economía I-ORG Industria I-ORG y I-ORG Competitividad I-ORG to I-ORG Luis I-ORG F. I-ORG Ciria I-ORG BES-2014-069050 O and O to O Rafael B-ORG Ballester I-ORG FPU13-05605 O and O research O grants O from O the O “Ministerio O de O Economía O Industria O y O Competitividad” O PSI2013-46385-P O and I-AWARD PSI2016-75956-P O and O the O “Junta B-ORG de I-ORG Andalucía” I-ORG SEJ-6414 O to O Daniel O Sanabria O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Special B-ORG Fund I-ORG for I-ORG Scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG of I-ORG Fujian I-ORG Province I-ORG 2021R1035003 O the B-ORG projects I-ORG from I-ORG Fujian I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG CXTD2021016-2 O XTCXGC2021007 B-AWARD and O Seed B-ORG Industry I-ORG Innovation I-ORG and I-ORG Industrialization I-ORG Project I-ORG of I-ORG Fujian I-ORG Province I-ORG zycxny2021011 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31770067 O 31470205 B-AWARD and O 31470174 B-AWARD the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2015CB755700 O and O the O Ministry B-ORG of I-ORG Agriculture I-ORG Transgenic O Program O No. O 2016ZX08009003-002 B-AWARD This O study O was O also O conducted O with O the O support O of O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG 2014-2018 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG Central I-ORG Non-profit I-ORG Scientific I-ORG Institution I-ORG 0392017002 O and O the O Postgraduate O Domestic O Visiting O Research O Project O of O Jiangxi O Normal O University O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81473201 B-AWARD the O Fund B-ORG of I-ORG Zunyi I-ORG Medical I-ORG University I-ORG No. O F-900 B-AWARD the O Fund B-ORG of I-ORG Zunyi I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG I-ORG Zunyi I-ORG Medical I-ORG University I-ORG No. O 2018-23 B-AWARD The B-ORG Science I-ORG and I-ORG Technology I-ORG Foundation I-ORG of I-ORG Guizhou I-ORG Province I-ORG of I-ORG China O No. O JZ B-AWARD 2014]2016 O and O Shijingshan’s B-ORG Tutor I-ORG Studio I-ORG of I-ORG Pharmacology I-ORG No. O GZS-2016-07 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O We O thank O Dr O Ciro O Chiappini O for O constructing O the O silicon O wafers O patterned O with O microgrooves O MMS O gratefully O acknowledges O support O from O the O Wellcome O Trust O Senior O Investigator O Award O “Exploring O and O Engineering O the O Cell-Material O Interface O for O Regenerative O Medicine” O 098411/Z/12/Z O MDS O was O supported O by O theBritish O Heart I-ORG Foundation(CH/08/002 O RE/08/002 B-AWARD RG/08/007 B-AWARD RM/13/1/30157 B-AWARD theEuropean O Research I-ORG Council(233158 O and O theMedical O Research I-ORG Council-BHF I-ORG Cardiovascular I-ORG Stem I-ORG Cell I-ORG Research I-ORG Strategic I-ORG DevelopmentGrant O G0901467 O This O study O was O supported O by O the O Earmarked B-ORG Fund I-ORG for I-ORG Modern I-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG CARS-43-B-1 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31972594 O and O Funds B-ORG of I-ORG Shandong I-ORG “Double I-ORG Tops” I-ORG Programme I-ORG SYL2017YSTD11 O The O funding O bodies O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O During O the O whole O course O of O this O study O the O study O design O data O analysis O data O interpretation O and O manuscript O preparation O were O mainly O supported O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China(Grand O No. O 2018YFC0910500 B-AWARD the O Neil O Shen’s O SJTU O Medical O Research O Fund O SJTU-Yale O Collaborative O Research O Seed O Fund O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grand O No. O 31728012 B-AWARD and O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG Grant O No. O 17DZ22512000 B-AWARD Data O collection O and O part O of O the O data O interpretation O were O supported O by O Lishui B-ORG medical I-ORG key I-ORG disciplines I-ORG Grand O No. O 2016zdxk06 B-AWARD and O Zhejiang B-ORG laboratory I-ORG animal I-ORG science I-ORG and I-ORG technology I-ORG program O Grand O No. O 2016C37145 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG http://www.nsfc.gov.cn O No. O 61473320 B-AWARD the O Fok B-ORG Ying I-ORG Tong I-ORG Education I-ORG Foundation I-ORG http://www.cutech.edu.cn/cn/kyjj/hydjyjj/A010302index_1.htm O No. O 141075 B-AWARD and O the O Project B-ORG of I-ORG Innovation-driven I-ORG Plan I-ORG in I-ORG Central I-ORG South I-ORG University I-ORG http://syl.csu.edu.cn/Content.aspx?moduleid=815fd225-685b-4165-bdb3-b20d6513ap11 O No. O 2016CSX014 B-AWARD These O funds O were O received O by O PW. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O U19AI07775 B-AWARD from O the O National B-ORG Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Disease I-ORG CM O HDTRA1-14-1-0018 B-AWARD from O the O Defense B-ORG Threat I-ORG Reduction I-ORG Agency I-ORG CM) O and O MCB-1151043 B-AWARD from O the O National B-ORG Science I-ORG foundation I-ORG PW O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Croatian B-ORG Science I-ORG Foundation I-ORG Grant O IP-2016-06-8861 O and O The O Croatian O Academy O of O Sciences O and O Arts O to O I.I.B O this O work O was O supported O by O The O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG BBSRC O BB/M020541-1 O to O E.L.B O and O Russian B-ORG Foundation I-ORG for I-ORG Basic I-ORG Research I-ORG grant O 16-04-00767 O to O E.S O This O work O was O supported O by O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2018M642627 B-AWARD Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG China I-ORG Grant O No. O ZR2018BEE029 B-AWARD National B-ORG Engineering I-ORG Laboratory I-ORG for I-ORG Ultra I-ORG High I-ORG Voltage I-ORG Engineering I-ORG Technology I-ORG Grant O No. O NEL201802 B-AWARD and O State O Key O of O Advanced O Electromagnetic O Engineering O and O Technology O Grant O No. O 2018KF002 B-AWARD This O project O was O supported O by O grants O from O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2014CB910600 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81273540 O and I-AWARD 81472684 O the O Program B-ORG for I-ORG New I-ORG Century I-ORG Excellent I-ORG Talents I-ORG in I-ORG University I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG NCET-13-0436 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2042014kf0236 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31670811 O 81402982 B-AWARD National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG China I-ORG 2018ZX09735-004 O NSFC-Shandong B-ORG Joint I-ORG Fund I-ORG for I-ORG Marine I-ORG Science I-ORG Research I-ORG Centers I-ORG U1606403 O Qingdao O National O Laboratory O for O Marine O Science O and O Technology O 2016ASKJ08-2 O Taishan O Scholar O Project O Special O Funds O TS201511011 O Shandong O Provincial O Major O Science O and O Technology O Innovation O Project O 2018SDKJ0404 O This O research O competition O was O supported O in O part O by O a O research O grant O from O NIST B-ORG IAD I-ORG Data I-ORG Science I-ORG Research I-ORG Program I-ORG by I-ORG the I-ORG Gordon I-ORG and I-ORG Betty I-ORG Moore I-ORG Foundation’s I-ORG Data-Driven I-ORG Discovery I-ORG Initiative I-ORG through O grant O GBMF4563 B-AWARD to O Ethan O P. O White O and O by O the O NSF B-ORG Dimension I-ORG of I-ORG Biodiversity I-ORG program I-ORG grant O DEB-1442280 O and O USDA/NIFA B-ORG McIntire-Stennis I-ORG program I-ORG FLA-FOR-005470 O to O Stephanie O Ann O Bohlman O This O work O was O supported O in O part O by O a O University O of O Florida O Biodiversity O Institute O Graduate O Fellowship O to O Sergio O Marconi O There O was O no O additional O external O funding O received O for O this O study O As O is O standard O for O government O agencies O the O paper O underwent O internal O review O by O NIST O Comments O from O these O four O authors O and O that O review O were O incorporated O into O the O manuscript O but O focused O on O communication O of O ideas O not O interpretation O of O results O This O work O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O No.81870922 O No.81801166 O No.81771291 O No.81901203 O No.81971127 O the O China B-ORG Scholarship I-ORG Fund I-ORG No.201606190196 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No.021414380361 O and O Medical B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Foundation I-ORG Nanjing I-ORG Department I-ORG of I-ORG Health I-ORG No.JQX18001 O P.B O is O supported O by O grants O from O NCI B-ORG CA253069 O and O CUNY B-ORG University I-ORG Committee I-ORG on I-ORG Research I-ORG Awards I-ORG PSC-CUNY O 52 O K.K O is O supported O in O part O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG R01GM123508 O and O the O Professional B-ORG Staff I-ORG Congress-City I-ORG University I-ORG of I-ORG New I-ORG York I-ORG PSC-CUNY O TRADB-49-271 O This O study O was O founded O by O the O grants O from O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81673734 B-AWARD I-AWARD 81170243 O and O Henan B-ORG Provincial I-ORG Science I-ORG and I-ORG Technique I-ORG Foundation I-ORG for I-ORG International I-ORG Cooperation I-ORG Program I-ORG No. O 162102410048 B-AWARD to O YW. O This O study O was O also O founded O in O part O by O the O Science B-ORG and I-ORG Technique I-ORG Foundation I-ORG from I-ORG the I-ORG Education I-ORG Department I-ORG of I-ORG Henan I-ORG Province I-ORG No. O 2010B360012 B-AWARD to O CS. O The O funding O body O provided O financial O support O and O had O no O role O in O the O design O of O the O study O collection O analysis O interpretation O of O data O or O writing O the O manuscript O This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2019YFB2203001 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61675087 B-AWARD the O Education B-ORG Department I-ORG of I-ORG Jilin I-ORG Province I-ORG JJKH20190118KJ O and O the O Science O and O Technology O Innovation O Development O Plan O of O Jilin O City O 201830793 O This O work O was O supported O by O NRF B-AWARD 2013R1A1A1010923 I-AWARD from O the O Basic O Science O Research O Program O through O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF I-ORG funded I-ORG by I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG Information I-ORG and I-ORG Communications I-ORG Technologies I-ORG ICT I-ORG and I-ORG Future I-ORG Planning O by O Core B-AWARD Grant I-AWARD P30-EY008126 I-AWARD from O the O National B-ORG Institutes I-ORG of I-ORG Health O and O by O Centennial B-AWARD Professor I-AWARD research I-AWARD funds I-AWARD from O Vanderbilt B-ORG University O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O Sichuan O Older O HIV-Infected O Cohort O Study O SOHICS O was O funded O by O research O grant O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81703279 O Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG 2019YJ0148 O Sichuan B-ORG Provincial I-ORG Foundation I-ORG for I-ORG AIDS I-ORG Prevention I-ORG and I-ORG Control I-ORG 2018-WJW-02 O and O the O International O Initiative O on O Spatial O Lifecourse O Epidemiology O ISLE O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O study O was O supported O by O the O Major B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Hunan I-ORG Province I-ORG 2017NK1014 O the O Forestry B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Hunan I-ORG Province I-ORG XLK201825 O XKL201731 B-AWARD the O Key B-ORG Technology I-ORG R&D I-ORG Program I-ORG of I-ORG Hunan I-ORG Province I-ORG 2016TP2007 O 2017TP2006 B-AWARD and O the O Key B-ORG Technology I-ORG R&D I-ORG Program I-ORG of I-ORG Changsha I-ORG kq1901145 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG of I-ORG China I-ORG 2016YFD0501207 O the B-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-36 O and O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG 2012CB124703 O Funding O for O this O project O included O AI137902 B-AWARD to O SBD O NMB B-ORG FB, O and O 1R011HD094009 B-AWARD to O EMS B-ORG OZ O is O supported O by O an B-ORG international I-ORG research I-ORG capacity-building I-ORG award I-ORG from I-ORG the I-ORG NIH-Fogarty I-ORG International I-ORG Center O D43TW010923 B-AWARD SBD O is O supported O by O K24AI141744 B-AWARD from O NIAID B-ORG NMB O is O supported O by O AI137902 O A.M.d.S O and O L.P O are O supported O by O U01AI151788 O This O work O was O supported O by O the O EU B-ORG 6th I-ORG Framework I-ORG Integrated I-ORG Project I-ORG 0187241 O Wellcome B-ORG Trust I-ORG 098461/Z/12/Z,106174/Z/14/Z O and O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG A90305 O A92181 B-AWARD The O research O materials O supporting O this O publication O can O be O accessed O by O contacting O the O corresponding O authors O This O work O was O supported O by O the O Social B-ORG Sciences I-ORG and I-ORG Humanities I-ORG Research I-ORG Council I-ORG of I-ORG Canada I-ORG SSHRC O in O the O form O of O a O grant O awarded O to O DF O 435-2019-1072 O the O Natural B-ORG Sciences I-ORG and I-ORG Engineering I-ORG Research I-ORG Council I-ORG of I-ORG Canada I-ORG NSERC O in O the O form O of O a O grant O awarded O to O DF O RGPIN-402513-2012 O Fonds B-ORG de I-ORG recherche I-ORG du I-ORG Québec I-ORG – I-ORG Société I-ORG et I-ORG culture I-ORG FRQSC O in O the O form O of O a O grant O awarded O to O CB O 189915 O and O Fonds O de O Recherche O du O Québec O – O Nature O et O technologies O FQRNT O in O the O form O of O a O graduate O scholarship O awarded O to O KR O and O IC. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 21804045 B-AWARD 21275059 I-AWARD and I-AWARD 21575044 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG 2018J05020 O and I-AWARD 2016J01062 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Xiamen I-ORG City I-ORG 3502Z20183027 O and I-AWARD 3502Z20183040 O Promotion O Program O for O Young O and O Middle-aged O Teacher O in O Science O and O Technology O Research O of O Huaqiao O University O ZQN-PY612 O and O Postgraduates’ O Innovative O Fund O in O Scientific O Research O of O Huaqiao O University O This O animal O challenge O model O experiment O and O the O design O of O the O study O and O collection O in O this O study O was O funded O by O the O National B-ORG Rabbit I-ORG Industry I-ORG Project I-ORG of I-ORG China I-ORG nycytx-44-3-2 O and O the O RT-PCR O ELISA O experiment O and O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O were O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 31402241 O and O Basic B-ORG Public I-ORG Welfare I-ORG Research I-ORG Projects I-ORG in I-ORG Zhejiang I-ORG Province I-ORG LGN18C180003 O and O Key O research O and O development O plan O of O Zhejiang O Province O No. O 2016C02054-10 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O project O was O supported O by O a O grant O from O Pediatric B-ORG Clinical I-ORG Research I-ORG Center I-ORG Foundation I-ORG of I-ORG Sichuan I-ORG Province I-ORG China I-ORG No.2017-46-4 O National O Science O and O Technology O Major O Project O of O China O No.2018ZX10103-001 O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG Central I-ORG Universities I-ORG No.2012017yjsy196 O and O Research B-ORG development I-ORG project I-ORG of I-ORG Sichuan I-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG No.2018SZ0130 O The O views O expressed O are O those O of O the O authors O and O not O necessarily O those O of O funders O The O funders O were O not O directly O involved O in O the O collection O analysis O and O interpretation O of O data O or O in O writing O the O manuscript O Prior O to O the O grant O being O awarded O the O funding O body O provided O feedback O on O the O study O design O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 31471748 B-AWARD Major B-ORG Fund I-ORG for I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 31330063 B-AWARD and O Mount O Tianzhu O Scholar O Funding O Scheme O Special B-ORG Fund I-ORG for I-ORG Agro-scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG grant O number O 201103018 B-AWARD Innovation B-ORG Fund I-ORG for I-ORG Translational I-ORG Medicine I-ORG of I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG School I-ORG of I-ORG Medicine O TM201812 B-AWARD Research B-ORG Fund I-ORG of I-ORG Medicine I-ORG and I-ORG Engineering I-ORG of I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University O ZH2018ZDA13 B-AWARD Youth B-ORG Fund I-ORG of I-ORG Medicine I-ORG and I-ORG Engineering I-ORG of I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University O YG2017QN08 B-AWARD Fund O of O Medicine O and O Engineering O of O Shanghai O Jiao O Tong O University O YG2017MS04 B-AWARD This O work O was O received O the O supported O of O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81803365 O 81803347 B-AWARD 31670360 B-AWARD and O 81973293 B-AWARD the O National B-ORG Key I-ORG R I-ORG I-ORG D I-ORG Programme I-ORG of I-ORG China I-ORG 2017YFA0503900 O 2018ZX09735-005 O and O Post-Doctor B-ORG Research I-ORG Project I-ORG 2018M643510 O 2019M650213 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2018A030313707 B-AWARD The O authors O have O no O other O relevant O affiliations O or O financial O involvement O with O any O organisation O or O entity O with O a O financial O interest O in O or O financial O conflict O with O the O subject O matter O or O materials O discussed O in O the O manuscript O apart O from O those O disclosed O This O work O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O under O Grant O No. O 62072402 B-AWARD the O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O No. O LGN22F020002 B-AWARD and O Key B-ORG Research I-ORG and I-ORG the I-ORG Development I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Province I-ORG under O Grant O No. O 2022C03037 B-AWARD The O research O was O supported O by O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O no: O DUT17RW207 B-AWARD the B-ORG National I-ORG Social I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O no: O 14CXW031 B-AWARD and O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O no: O 71473028 B-AWARD This O research O has O received O funding O from O the O European B-ORG Union I-ORG Horizon I-ORG 2020 I-ORG Research I-ORG and I-ORG Innovation I-ORG Programme I-ORG under I-ORG the I-ORG Marie I-ORG Sklodowska–Curie I-ORG grant O agreement O No. O 846636 B-AWARD This O work O was O also O supported O in O part O by O the O Universities B-ORG and I-ORG Research I-ORG Secretariat I-ORG from I-ORG the I-ORG Generalitat I-ORG de I-ORG Catalunya I-ORG under O Grant O GRC B-AWARD 2021 I-AWARD SGR I-AWARD 01390 I-AWARD and O by O the O Agencia B-ORG Estatal I-ORG de I-ORG Investigación I-ORG from I-ORG the I-ORG Spanish I-ORG Ministry I-ORG of I-ORG Science I-ORG Innovation I-ORG and I-ORG Universities I-ORG and I-ORG the I-ORG European I-ORG Regional I-ORG Development I-ORG Fund O under O the O Grant O PID2021-126455OB-I00 B-AWARD The O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51634010 O 31400115 B-AWARD 51474102 B-AWARD helped O in O the O purchase O of O equipment O analysis O and O test O of O the O samples O including O the O use O of O XPS O AFM O NMR O FTIR O and O XRD O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017M612594 O and O Postdoctoral B-ORG Science I-ORG Foundation I-ORG of I-ORG Central I-ORG South I-ORG University I-ORG 140050002 O mainly O helped O in O the O purchase O of O the O reagents O glassware O and O the O other O readily O available O experimental O necessities O such O as O concentrated O acid O alkali O tetrahydrofuran O and O hydrothermal O reactor O This O research O was O supported O by O grants O from O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O 2014M3C7A1064545 O to O K.C.C O funded O by O the O Ministry O of O Science O ICT O and O Future O Planning O MSIP O Republic O of O Korea O and O from O the O Korea O Healthcare O Technology O R&D O Project O HI14C0093 O to O K.C.C O through O the O Korea B-ORG Health I-ORG Industry I-ORG Development I-ORG Institute I-ORG KHIDI O funded O by O the O Ministry O of O Health O O Welfare O Republic O of O Korea O This O work O was O also O supported O in O part O by O NRF O grant O 2015R1A2A2A01003080 O to O K.C.C O by O the O Yonsei B-ORG University I-ORG Research I-ORG Fund I-ORG of I-ORG 2014 I-ORG 2014-12-0134 O to O E.I O and O by O Yonsei B-ORG University I-ORG Future-leading I-ORG Research I-ORG Initiative I-ORG of I-ORG 2015 I-ORG 2015-22-0055 O to O K.C.C O JSK O was O supported O by O DFG B-ORG project O 432290010 B-AWARD BMBF O German O Ministry I-ORG of I-ORG Education I-ORG and I-ORG Research O 13GW0469D B-AWARD and O ERC O SS O was O supported O by O an O internal B-ORG faculty I-ORG grant I-ORG KKF O 8700000708 B-AWARD This O work O has O received O research O funding O from O the O European B-ORG Research I-ORG Council I-ORG ERC O under O the O European O Union’s O Horizon O 2020 O research O and O innovation O program O 101045128—iBack-epic—ERC-2021-COG O This O work O was O supported O in O part O by O a O grant O from O the O Associazione B-ORG Italiana I-ORG per I-ORG la I-ORG Ricerca I-ORG sul I-ORG Cancro I-ORG IG2017 B-AWARD n. I-AWARD 20299 O the O International B-ORG Myeloma I-ORG Foundation I-ORG under O 2018 O Brian B-AWARD D. I-AWARD Novis I-AWARD Senior I-AWARD Research I-AWARD Grant I-AWARD and O a O grant O from O the O Ministero B-ORG della I-ORG Salute I-ORG Italiana O PE-2016-02361261 B-AWARD Research O in O Ikeda O Lab O is O supported O by O theFWF O standalone I-ORG grant I-ORG Austrian I-ORG science I-ORG fund[P O 25508 B-AWARD theERC O consolidator I-ORG grant[LUbi O 614711 B-AWARD theCOST O European I-ORG Cooperation I-ORG in I-ORG Science I-ORG and I-ORG Technology[PROTEOSTASIS O BM1307 B-AWARD and O the O Austrian O Academy O of O Sciences O This O work O was O supported O by O funds O from O the O Guangzhou B-ORG Institute I-ORG of I-ORG Pediatrics/Guangzhou I-ORG Women I-ORG and I-ORG Children I-ORG Medical I-ORG Center I-ORG grant O number O YIP-2019-023 B-AWARD Guangzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG grant O number O 201804010142 B-AWARD and O Guangdong B-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG grant O number O 2016ZC0227 B-AWARD The O funding O body O had O no O role O in O the O design O of O the O study O collection O analysis O and O interpretation O of O data O or O in O writing O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81501001 B-AWARD Beijing B-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospitals I-ORG Incubating I-ORG Program I-ORG Code O PX2020022 B-AWARD Beijing B-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospitals’ I-ORG Apex I-ORG Plan I-ORG No. O DFL20150501 B-AWARD and O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG 2017ZX09304018 O The O funders O had O no O role O in O study O design O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O financially O supported O by O grants O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 31672414 B-AWARD the B-ORG National I-ORG Key I-ORG R&D I-ORG program I-ORG of I-ORG China I-ORG Grant O No. O 2021YFD1300100 B-AWARD and O the B-ORG Funds I-ORG of I-ORG Shandong I-ORG “Double I-ORG Tops” I-ORG Program I-ORG SYL2017YSTD12 O The O funding O body O had O no O role O in O the O design O of O the O study O and O in O the O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O study O was O in O part O supported O by O a O National B-ORG Institute I-ORG of I-ORG Environmental I-ORG Health I-ORG Sciences I-ORG funded O training O grant O in O Environmental O Health O Sciences O T32 O ES007059 O the O Center B-ORG for I-ORG Children’s I-ORG Environmental I-ORG Health I-ORG funded O by O the O National O Institute O of O Environmental O Health O Sciences O NIEHS O P01ES011269 O and O US B-ORG Environmental I-ORG Protection I-ORG Agency I-ORG US O EPA I-AWARD R829388 O R833292 B-AWARD and O 8354320 B-AWARD Science O to O Achieve O Results O STAR O program O and O the O National O Institute O of O Environmental O Health O Sciences O NIEHS O 1R01ES020392 O 2R01 B-AWARD ES014901 O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the B-ORG Project I-ORG Supported I-ORG by I-ORG the I-ORG Open I-ORG Fund I-ORG of I-ORG Key I-ORG Laboratory I-ORG of I-ORG Urban I-ORG Land I-ORG Resources I-ORG Monitoring I-ORG and I-ORG Simulation I-ORG Ministry I-ORG of I-ORG Land I-ORG and I-ORG Resources I-ORG KF-2018-03-050 O and O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M642800 O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China(2017YFC1502600 O This O study O has O received O funding O from O the O European B-ORG Union’s I-ORG Horizon I-ORG 2020 I-ORG Research I-ORG and I-ORG Innovation I-ORG Programme I-ORG under O Grant O Agreement O No O 862834 B-AWARD The O results O of O this O project O solely O reflect O this O consortium’s O view O and O the O European O Commission O is O not O responsible O for O any O use O that O may O be O made O of O the O information O it O contains O This O work O was O also O supported O by O the O Foundation B-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG FCT O and O the O Portuguese O National O Budget O funding O through O projects O UIDB/04326/2020 B-AWARD and O UIDP/04326/2020 B-AWARD and O the O FCT B-ORG Scientific I-ORG Employment I-ORG Stimulus I-ORG CEECIND/00425/2017 O Luísa O Custódio).and O Fundo B-ORG Azul I-ORG FA-05-2017-028 O Additionally O this O work O was O conducted O as O part O of O the O HaloFarMs O project O under O the O Partnership O on O Research O and O Innovation O in O the O Mediterranean O Area O PRIMA O Programme O which O is O supported O by O the O European O Union O and O funded O by O the O national O funding O bodies O of O Participating O States O FCT O in O Portugal O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 32102080 B-AWARD 31801631 B-AWARD 1601360061 B-AWARD 32150410347 B-AWARD 32272407 B-AWARD Zhejiang B-ORG Postdoctoral I-ORG Programs O grant O number O ZJ2022135 B-AWARD Postdoctoral B-ORG project I-ORG of I-ORG Institute I-ORG of I-ORG Modern I-ORG Agriculture I-ORG and I-ORG Health I-ORG Care I-ORG Industry I-ORG of I-ORG Wencheng O grant O number O 2022NKY05 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province O grant O number O BK20220058 B-AWARD BK20200103 B-AWARD BK2022011 B-AWARD Foundation B-ORG of I-ORG Jiangsu I-ORG Specially-Appointed I-ORG Professor O grant O number O 202074 B-AWARD This O work O was O supported O by O the O National B-ORG Special I-ORG Research I-ORG Fund I-ORG for I-ORG Non-Profit I-ORG Sector I-ORG Agriculture I-ORG No.201203015 O Academy B-ORG of I-ORG Kechuang I-ORG Feed I-ORG Industry I-ORG in I-ORG Sichuan I-ORG 2013NZ0056 O Research B-ORG Team I-ORG of I-ORG Youth I-ORG Scientific I-ORG and I-ORG Technical I-ORG Innovation I-ORG of I-ORG Sichuan I-ORG 13CXTD0004 O and O the O Program B-ORG for I-ORG Changjiang I-ORG Scholars I-ORG and I-ORG Innovative I-ORG Research I-ORG Team I-ORG in I-ORG University I-ORG IRT13083 O This O research O was O funded O by O Kerman B-ORG University I-ORG of I-ORG Medical I-ORG Sciences O Kerman O Iran O and O the O financial O supports O of O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea O grant O number O 2016M3D1A1027666 B-AWARD and O 2017R1A2B3009135 B-AWARD Neuroscience O Research O Center O Kerman O University O of O Medical O Sciences O Kerman O Iran O grant O number O 98000289 B-AWARD and O ethics O code O EC/98-28/KNRC B-AWARD China B-ORG Scholarship I-ORG Council O grant O number O 201808260042 B-AWARD Bio O O Medical O Technology O Development O Program O 2018M3A9H1023141 O Creative O Materials O Discovery O Program O through O the O NRF O funded O by O Ministry O of O Science O and O ICT O grant O number O 2017M3D1A1039379 O Basic O Research O Laboratory O of O the O NRF O funded O by O the O Korean O government O grant O number O 2018R1A4A1022647 O This O research O was O funded O by O The O Nature B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG grant O number O LQ20G030008 B-AWARD The O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 72203204 B-AWARD and O The O Humanities B-ORG and I-ORG Social I-ORG Sciences I-ORG project I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG grant O number O 22YJC790185 B-AWARD This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81702008 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG H2018406024 O Foundation O for O High-level O Talents O of O Chengde B-ORG Medical I-ORG University I-ORG 201702 O The O funding O body O played O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O study O was O supported O by O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Agency I-ORG NSTDA I-ORG for I-ORG the I-ORG Research I-ORG Chair I-ORG Grant I-ORG P-15-50004 O and O the O Center B-ORG of I-ORG Excellence I-ORG in I-ORG Clinical I-ORG Virology I-ORG at I-ORG Chulalongkorn I-ORG University I-ORG GLE O 58-014-30-004 I-AWARD RES560530093 O Chulalongkorn O University O and O Hospital O Srinakharinwirot B-ORG University I-ORG 276/2560 O Our O research O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Fund I-ORG of I-ORG China I-ORG Award O No. O 51778267 B-AWARD the O National B-ORG Water I-ORG Pollution I-ORG Prevention I-ORG and I-ORG Treatment I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG No. O 2012ZX07408001 B-AWARD and O the O Jilin B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG Project I-ORG No. O 20220203047SF B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 42077219 O the O Hangzhou B-ORG Municipal I-ORG Agriculture I-ORG and I-ORG Social I-ORG Development I-ORG Project I-ORG 2020ZDSJ0697 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Provincial I-ORG Universities I-ORG of I-ORG Zhejiang I-ORG SJLY2020011 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82203447 O 1.3.5 O Project O for O Disciplines O of O Excellence O West B-ORG China I-ORG Hospital I-ORG ZYJC21021 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Sichuan I-ORG China I-ORG 2022NSFSC1424 O and O the O Postdoctoral O Research O Project O West B-ORG China I-ORG Hospital I-ORG Sichuan I-ORG University I-ORG 18HXBH068 O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O no. O 81673349 B-AWARD International O S&T O Cooperation O Program O of O China O 2012DFA30600 O Zhejiang B-ORG Province I-ORG Public I-ORG Technology I-ORG Research I-ORG Project I-ORG LGN18D060002 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG of I-ORG China I-ORG LY17C200011 O This O research O was O funded O by O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O NO. O 61905179 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG Grant O NO. O F2022103002 B-AWARD Key B-ORG R&D I-ORG projects I-ORG in I-ORG Hebei I-ORG Province I-ORG Grant O NO. O 22351101D B-AWARD Karolinska B-ORG Institutet´s O KID O funding O US50124002 O and O the O Swedish B-ORG Cancer I-ORG Foundation I-ORG 19 O 0495 I-AWARD Pj; O CAN2016/731 B-AWARD to O MSC O MC O is O supported O by O DZIF O TTU O 05.702 O CFS O and O MC O are O supported O by O the O Deutsche B-ORG Forschungsgemeinschaft I-ORG DFG O under O Germany’s O Excellence O Strategy—EXC O 2155 O “RESIST”—Project O ID O 39087428 B-AWARD The O present O study O were O funded O by O Liaoning B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Project I-ORG Grant O Number O 180530068 B-AWARD Shenyang B-ORG Technology I-ORG Project I-ORG Grant O Number O 17231178 B-AWARD and O the B-ORG Outstanding I-ORG Young I-ORG Doctor I-ORG Fund I-ORG of I-ORG China I-ORG Medical I-ORG University I-ORG Grant O Number O QGZD2018050 B-AWARD This O study O was O funded O by O ReproF1 O Project O Programa O Operacional I-ORG Mar2020 O MAR-16-02-01-FMP-0059 B-AWARD and O CONDISOLE O CeiMar O funds O CEIJ-005 B-AWARD This O work O was O also O supported O by O CCMAR B-ORG Strategic I-ORG Plan—UIDB/04326/2020 O UIDP/04326/2020 B-AWARD and O LA/P0101/2020 B-AWARD E. O Fatsini O was O supported O by O Foundation B-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG FCT O contract O 2020.04181.CEECIND B-AWARD The O authors O gratefully O acknowledge O the O Natural B-ORG Science I-ORG Foundation I-ORG for I-ORG Youth I-ORG Scholars I-ORG of I-ORG Jiangsu I-ORG Province I-ORG of I-ORG China I-ORG No. O BK20150070 B-AWARD the O National B-ORG Nonprofit I-ORG Institute I-ORG Research I-ORG Grant I-ORG of I-ORG CAFINT I-ORG No. O CAFINT2014C10 B-AWARD and O the O Forestry B-ORG “Three I-ORG New” I-ORG Projects I-ORG of I-ORG Jiangsu I-ORG Province I-ORG of I-ORG China I-ORG No. O LYSX B-AWARD 2014 I-AWARD 09 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O the O APIMedOlder B-ORG project I-ORG PTDC/MED-FAR/31598/2017 O funded O by O the O operational B-ORG programme I-ORG of I-ORG competitiveness I-ORG and I-ORG internationalization I-ORG POCI O in O its O FEDER/FNR O component O POCI-01-0145-FEDER-031598 B-AWARD and O the O Foundation O for O Science O and O Technology—FCT O The O participation O of O Ana O Isabel O Plácido O in O this O work O was O funded O by O the O Grant O CENTRO-04-3559-FSE-000162 B-AWARD financed O by O the O Operational O Program I-ORG from I-ORG the I-ORG budget I-ORG of I-ORG the I-ORG Central I-ORG Region I-ORG of I-ORG Portugal I-ORG within I-ORG the I-ORG European I-ORG Social I-ORG Fund I-ORG ESF I-ORG component I-ORG This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2021YFD1401100 I-AWARD to O HH O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 32000121 I-AWARD to O GL O the O Project B-ORG of I-ORG the I-ORG State I-ORG Key I-ORG Laboratory I-ORG for I-ORG Managing I-ORG Biotic I-ORG and I-ORG Chemical I-ORG Threats I-ORG to I-ORG the I-ORG Quality I-ORG and I-ORG Safety I-ORG of I-ORG Agro-products I-ORG No. O ZS20190102 I-AWARD to O JC) O and O the O Ningbo B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG 2025 I-ORG Major I-ORG Project I-ORG No. O 2019B10004 I-AWARD to O JC O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O Consejo B-ORG Nacional I-ORG de I-ORG Ciencia I-ORG y I-ORG Tecnología I-ORG CONACyT O grant O number O A1-S-7495 B-AWARD Programa B-ORG de I-ORG Apoyo I-ORG a I-ORG Proyectos I-ORG de I-ORG Investigación I-ORG e I-ORG Innovación I-ORG Tecnológica I-ORG PAPIIT O grant O number O IN200922 B-AWARD and O Programa B-ORG de I-ORG Apoyo I-ORG a I-ORG la I-ORG Investigación I-ORG y I-ORG el I-ORG Posgrado I-ORG PAIP O grant O number O 5000-9105 B-AWARD Z.A.C.-G O is O a O student O from O Posgrado O en O Ciencias O Bioquímicas O at O the O Universidad O Nacional O Autónoma O de O México O and O is O a O recipient O of O a O scholarship O from O CONACyT O Mexico O CVU O 743972 O A.K.A.-R O and O I.A-M O are O students O from O Posgrado O en O Ciencias O Biológicas O at O Universidad O Nacional O Autónoma O de O México O and O are O recipients O of O a O scholarship O from O CONACyT O Mexico O CVU O 818062 O and O 780369 O respectively O This O work O was O supported O partially O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61502135 B-AWARD the O Programme B-ORG of I-ORG Introducing I-ORG Talents I-ORG of I-ORG Discipline I-ORG to I-ORG Universities I-ORG No. O B14025 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O JZ2015HGBZ0111 B-AWARD The O funding O bodies O had O no O role O in O study O design O data O collection O and O analysis O or O preparation O of O the O manuscript O This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81802565 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grant O No. O BK20180216 B-AWARD Key B-ORG Project I-ORG of I-ORG the I-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG Nanjing I-ORG Medical I-ORG University I-ORG Affiliated I-ORG Suzhou I-ORG Hospital I-ORG Grant O No. O szslyy2017005 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O received O support O from O grant O 2016YFC0900502 O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Min O Yu O grant O 41401143 O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Wei-Wei O Gong O grant O 201502060 O from O Tongxiang B-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG Kai-Xu O Xie O The O sponsors O or O funders O did O not O play O any O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61501185 O and O the O Hebei B-ORG Province I-ORG Natural I-ORG Science I-ORG Foundation I-ORG F2016502062 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2015MS125 O 2016MS97 B-AWARD and O the O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 4164101 O and O the O Shaanxi O STA O International O Cooperation O and O Exchanges O Project O 2017KW-011 O The O APC O was O funded O by O the O Fundamental O Research O Funds O for O the O Central O Universities O 2015MS125 O The O research O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O U22A20423 B-AWARD 22208358 B-AWARD and O 52173291 B-AWARD Qingdao B-ORG independent I-ORG innovation I-ORG major I-ORG project I-ORG No. O 21-1-2-23-hz B-AWARD and O Shandong B-ORG Energy I-ORG Institute I-ORG Research I-ORG Foundation I-ORG No. O SEI B-AWARD S202106 O This O research O received O support O from O the O Italian O Ministry O of O Education O University O and O Research O Progetti B-ORG Futuro I-ORG in I-ORG Ricerca I-ORG 2012 I-ORG RBFR126B8I O to O AA) O and O Progetti B-ORG Ricerca I-ORG Interesse I-ORG Nazionale I-ORG 2012 I-ORG 2012JA4BTY O to O AA O the O University O of O Pavia O strategic O theme O MIGRATions B-ORG towards I-ORG an I-ORG INterdisciplinary I-ORG Governance I-ORG model O MIGRAT.IN.G O to O AA O We O thank O Dr. O Giovanni O Capuzzello O and O Dr. O Gilberto O Leonelli O for O their O precious O help O in O providing O biological O samples O for O Modicana O and O Bianca O di O Val O Padana O breeds O respectively O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O project O was O funded O by O the O RACV O Safety O Research O Fund:https://www.racv.com.au O The O project O was O also O funded O by O the O Victorian O State O Government O Department O of O Health O and O Human O Services:https://dhhs.vic.gov.au O The O project O was O funded O by O the O Royal O Australasian O College O of O Surgeons O RACS O Foundation O of O Surgery:https://www.surgeons.org O The O project O was O funded O by O the O Australian O Resuscitation O Council O Victorian O Branch):https://resus.org.au/victorian-branch O The O Victorian O State O Trauma O Registry O VSTR O is O a O Department O of O Health O State O Government O of O Victoria O and O Transport O Accident O Commission O funded O project:https://www.tac.vic.gov.au O BB O received O an O Australian B-ORG Research I-ORG Council I-ORG Discovery O Early O Career O Researcher O Award O Fellowship O DE180100825):https://www.arc.gov.au O BG O received O an O Australian B-ORG Research I-ORG Council I-ORG Future I-ORG Fellowship I-ORG FT170100048):https://www.arc.gov.au O WT O received O a O grant O from O the O Royal O Children’s O Hospital O Foundation:https://www.rchfoundation.org.au O PC O received O a O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG NHMRC I-ORG Practitioner I-ORG Fellowship I-ORG #545926):https://nhmrc.gov.au O This O study O was O supported O by O the O Cultivating B-ORG Talents I-ORG of I-ORG the I-ORG Middle-aged I-ORG Academic I-ORG and I-ORG Technology I-ORG Leaders I-ORG of I-ORG Yunnan I-ORG Province I-ORG No. O 2015HB029 B-AWARD the O Open B-ORG Fund I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Loess I-ORG and I-ORG Quaternary I-ORG Geology I-ORG SKLLQG1020 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O U0933604 B-AWARD This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 31870928 B-AWARD and O 32271360 B-AWARD the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG grant O numbers O 2021A1515010040 B-AWARD and O 2023A1515010829 B-AWARD and O the B-ORG Overseas I-ORG Master I-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Guangdong I-ORG Province I-ORG grant O number O x2swB2210620 B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Council I-ORG of I-ORG Taiwan I-ORG MOST O 111-2314-B-303-017-MY3 I-AWARD and O MOST B-AWARD 111-2628-B-371-001 O Taipei B-ORG Tzu I-ORG Chi I-ORG Hospital I-ORG TCRD-TPE-MOST-111-12 O and O TCRDTPE-111-07 B-AWARD Buddhist B-ORG Tzu I-ORG Chi I-ORG Medical I-ORG Foundation I-ORG TCMF-A O 107-01-13(112 I-AWARD and O TCMF-JCT B-AWARD 111-17 O and O the O Changhua B-ORG Christian I-ORG Hospital I-ORG Research I-ORG Foundation I-ORG 111-CCH-IRP-058 O and O 111-CCH-IRP-031 B-AWARD The O funders O had O no O role O in O the O study O design O data O collection O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O by O the O Scientific O and O Technological O Major O Special O Program O of O Breeding B-ORG for I-ORG Agricultural I-ORG New I-ORG Varieties I-ORG in I-ORG Zhejiang I-ORG Province I-ORG Nos O 2016C02052-2 B-AWARD and O 2012C12904-3 O the B-ORG Prior I-ORG Project I-ORG Fund I-ORG for I-ORG Agriculture I-ORG of I-ORG Zhejiang I-ORG Province I-ORG Nos O 2012C12009-5 B-AWARD and I-AWARD 2009C12058 O and O the B-ORG Public I-ORG Service I-ORG Sectors I-ORG of I-ORG Agricultural I-ORG Special I-ORG Projects I-ORG No. O 201203089 B-AWARD The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O interpretation O of O data O or O writing O of O the O manuscript O This O work O was O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG Grant O no. O 2018A030310666 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O no. O 31672626 B-AWARD Innovation B-ORG Team I-ORG Project I-ORG from I-ORG the I-ORG Department I-ORG of I-ORG Education I-ORG of I-ORG Guangdong I-ORG Province I-ORG Grant O no. O 2017KCXTD016 B-AWARD Modern B-ORG Agricultural I-ORG Industrial I-ORG System I-ORG CARS-049 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Fundación B-ORG Mutua I-ORG Madrileña I-ORG 4131220 O to O LO-T O and O TO) O The O National O Institute O of O Biomedical O Imaging O and O Bioengineering O 1K23EB019023-01RM O to O JS O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG R01HD069776 O R01NS073601 B-AWARD R21 B-AWARD MH099196 O R21 B-AWARD NS082870 O R21 B-AWARD NS085491 O R21 B-AWARD HD07616 I-AWARD to O AP-L O the O Berenson-Allen O Foundation O to O AP-L O the O Sidney O R. O Baer O Jr. O Foundation O to O AP-L O and O the O Harvard B-ORG Catalyst I-ORG O The O Harvard O Clinical O and O Translational O Science O Center O NCRR O and O the O NCATS O NIH O UL1 B-AWARD RR025758 I-AWARD to O AP-L O This O research O was O funded O by O the O Science B-ORG Foundation I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG grant O number O Z22E035302 O and O LGG20B040002 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG grant O number O ZR2020LFG004 O And O the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Hangzhou I-ORG was O funded O by O 20201203B136 O 20201203B134 B-AWARD and O 20191203B16 B-AWARD This O work O was O supported O by O UC-MEXUS B-ORG CN-15-1476 O the O National B-ORG Science I-ORG Foundation I-ORG No. O 1546719 B-AWARD and O the O Consejo B-ORG Nacional I-ORG de I-ORG Ciencia I-ORG y I-ORG Tecnología I-ORG CB-2015-01 O 254012 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Medical B-ORG Research I-ORG Council I-ORG Career O Development O Award O MR/S006990/1 O JNS O a O Wellcome B-ORG Trust I-ORG Senior O Investigator O Award O 107116/Z/15/Z O GS O the O European O Union’s O Horizon B-ORG 2020 I-ORG Research O and O Innovation O programme O under O grant O agreement O 739572 B-AWARD GS] O and O the O UK O Dementia O Research O Institute O Foundation O award O UKDRI-1005 O GS O National B-ORG Research I-ORG Development I-ORG and I-ORG Innovation I-ORG Office I-ORG of I-ORG Hungary O GINOP-2.3.2-15-2016-00044;K1328142017-1.3.1-vke-2017-00026 B-AWARD Higher B-ORG Education I-ORG Institutional I-ORG Excellence I-ORG Programme I-ORG NKFIH-1150-6/2019 O of O the O Ministry B-ORG of I-ORG Innovation I-ORG and I-ORG Technology I-ORG in I-ORG Hungary O FIKP_20428-3_2018_FELITSTRAT B-AWARD This O paper O was O funded O by O the O Second B-ORG Tibetan I-ORG Plateau I-ORG Scientific I-ORG Expedition I-ORG and I-ORG Research I-ORG Program I-ORG 2019QZKK0704 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 42288201 O 41688103 B-AWARD 91514302 B-AWARD 41972010 B-AWARD the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDB26000000 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Ningxia I-ORG 2021AAC03471 O and O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Paleobiology I-ORG and I-ORG Stratigraphy I-ORG Nanjing O Institute O of O Geology O and O Paleontology O CAS O 213115 O This O study O was O supported O by O a O grant O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundations I-ORG of I-ORG China I-ORG 31201772 O Chinese B-ORG Universities I-ORG Scientific I-ORG Fund I-ORG 2014XJ003 O and O the B-ORG Program I-ORG for I-ORG Changjiang I-ORG Scholars I-ORG and I-ORG Innovative I-ORG Research I-ORG Team I-ORG in I-ORG University I-ORG IRT_15R62 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21934006 O 22274153 B-AWARD 22174141 B-AWARD 22274151 B-AWARD and O 22074145 B-AWARD the O Innovation O Program O DICP O I202004 O of O Science O and O Research O from O Dalian B-ORG Institute I-ORG of I-ORG Chemical I-ORG Physics I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences O and O the O AI O S&T O Program O Grant O No. O DNL-YL B-AWARD A202202 O from O Yulin B-ORG Branch I-ORG Dalian I-ORG National I-ORG Laboratory I-ORG for I-ORG Clean I-ORG Energy I-ORG CAS I-ORG China I-ORG The O author(s O received O specific O fundings O for O this O work O European O Union’s I-ORG Horizon I-ORG 2020 I-ORG Research I-ORG and I-ORG Innovation I-ORG Programme I-ORG under I-ORG Zika-PLAN I-ORG 734584 B-AWARD Maria O Elisabeth O lopes O Moreira O Wellcome O Trust I-ORG 205377/Z/16/Z B-AWARD Dr O Elizabeth O Brickley O Conselho O Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq B-AWARD 441098/2016-9 I-AWARD Maria O Elisabeth O lopes O Moreira O Faperj O E-26/202.979/2017 B-AWARD Maria O Elisabeth O lopes O Moreira O PIP2/IFF/Fiocruz O IFF-002Fio1628 B-AWARD Maria O Elisabeth O lopes O Moreira O NIH/NIAID O O RO1 O AI140718 O This O project O was O supported O by O the O National B-ORG S I-ORG I-ORG T I-ORG Major I-ORG Program I-ORG grant O no. O 2012ZX10004220 B-AWARD Project B-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81101275 B-AWARD and O Capacity B-ORG improvement I-ORG project I-ORG of I-ORG Jiangsu I-ORG Public I-ORG Welfare I-ORG Institute I-ORG No. O BM2015024 B-AWARD This O research O was O funded O by O the O Amazon B-ORG Foundation I-ORG for I-ORG Research I-ORG Support I-ORG FAPESPA O 006/2020 O Secretary B-ORG of I-ORG Science I-ORG Technology I-ORG and I-ORG Higher I-ORG Professional I-ORG and I-ORG Technological I-ORG Education I-ORG SECTET O 09/2021 O Higher B-ORG Education I-ORG Personnel I-ORG Improvement I-ORG Coordination I-ORG Brazil I-ORG CAPES O Finance O Code O 001 O Notice O no. O 13/2020 B-AWARD and O the O National B-ORG Council I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Development I-ORG Brazil I-ORG INCT O 406360/2022-7 B-AWARD The B-ORG second I-ORG scientific I-ORG expedition I-ORG to I-ORG the I-ORG Qinghai-Tibet I-ORG Plateau I-ORG 2019QZKK0405-05 B-AWARD National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG 2016YFC0502103 B-AWARD National B-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG of I-ORG China I-ORG 41571173 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG of I-ORG MOF I-ORG and I-ORG MARA I-ORG CARS-23 O Collaborative B-ORG Innovation I-ORG Center I-ORG of I-ORG Beijing I-ORG Academy I-ORG of I-ORG Agricultural I-ORG and I-ORG Forestry I-ORG Sciences I-ORG KJCX201915 O Special B-ORG Innovation I-ORG Ability I-ORG Construction I-ORG Fund I-ORG of I-ORG Beijing I-ORG Academy I-ORG of I-ORG Agricultural I-ORG and I-ORG Forestry I-ORG Sciences I-ORG KJCX20220418 O 20210402 B-AWARD 20200427 B-AWARD and O 20210437 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31772022 O and O 32001763 B-AWARD and O the O Young B-ORG Investigator I-ORG Fund I-ORG of I-ORG Beijing I-ORG Academy I-ORG of I-ORG Agricultural I-ORG and I-ORG Forestry I-ORG Sciences I-ORG QNJJ202235 O This O work O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG the I-ORG 14th I-ORG Five-Year I-ORG Plan I-ORG China I-ORG 2021YFD1600203 O and O the O Key B-ORG Laboratory I-ORG of I-ORG Colleges I-ORG and I-ORG Universities I-ORG of I-ORG Sichuan I-ORG Province—Laboratory I-ORG of I-ORG Animal I-ORG Medicine I-ORG China I-ORG 2021PTJS34 O Innovation B-ORG team I-ORG for I-ORG emerging I-ORG animal I-ORG diseases I-ORG Southwest I-ORG Minzu I-ORG University I-ORG grant O number O 2020NTD02 B-AWARD This O work O was O supported O by O The O Scientific B-ORG Research I-ORG Translational I-ORG Foundation I-ORG of I-ORG Wenzhou I-ORG Safety I-ORG Emergency I-ORG Institute I-ORG of I-ORG Tianjin I-ORG University I-ORG TJUWYY2022019 O TJUWYY2022002 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Nankai I-ORG University I-ORG 63221058 O Tianjin B-ORG Research I-ORG Innovation I-ORG Project I-ORG for I-ORG Postgraduate I-ORG Students I-ORG 2021YJSB193 O The O research O was O supported O by O Bill B-ORG and I-ORG Melinda I-ORG Gates I-ORG Foundation I-ORG Global I-ORG Health I-ORG Program I-ORG OPPGH5336 O by O Charles B-ORG University I-ORG Research I-ORG Centre I-ORG UNCE O 204072 O MS O by O the O Centre B-ORG for I-ORG research I-ORG of I-ORG pathogenicity I-ORG and I-ORG virulence I-ORG of I-ORG parasites I-ORG CZ.02.1.01/0.0/0.0/16_019/0000759 O PV O and O by O the O Czech B-ORG Science I-ORG Foundation I-ORG P506 O 17-10308S O MS, O PV O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O is O supported O and O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 71804094 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No.2016M592161 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG No. O ZR2016GB02 B-AWARD Postdoctoral B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG No. O 201603021 B-AWARD The O Fundamental O Research O Funds O of O Shandong O University O No. O 2015HW002 B-AWARD No. O 2018JC055 B-AWARD This O work O was O supported O in O part O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2016YFD0200501-9 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31401742 O and O the B-ORG PhD I-ORG Research I-ORG Funding I-ORG of I-ORG Southwest I-ORG University I-ORG SWU118110 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81760157 O 21701068 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Province I-ORG No. O 20171BAB215074 B-AWARD and O Science B-ORG and I-ORG Technology I-ORG Research I-ORG Projects I-ORG of I-ORG the I-ORG Education I-ORG Department I-ORG of I-ORG Jiangxi I-ORG Province I-ORG No. O GJJ160383 B-AWARD This O study O was O supported O through O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O Grant/Award O Number O 81602545 B-AWARD Scientific B-ORG Research I-ORG Project I-ORG of I-ORG Huashan I-ORG Hospital I-ORG Fudan I-ORG University O Grant/Award O Number O 2016Q018 B-AWARD and O Scientific B-ORG Research I-ORG Project I-ORG of I-ORG Huashan I-ORG North I-ORG Hospital O Fudan O University O Grant/Award O Number:2015115 O This O research O was O funded O by O “Research O on I-ORG Distributed I-ORG Optical I-ORG Fiber I-ORG Flow I-ORG Monitoring I-ORG and I-ORG Interpretation I-ORG Technology” O P21052 O “The O Key I-ORG Technology I-ORG and I-ORG Application I-ORG of I-ORG marine I-ORG Deep I-ORG Space I-ORG Development I-ORG and I-ORG Utilization” O SKJC-KJ-2019KY02 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 62263009 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangxi I-ORG Province I-ORG 2020GXNSFAA297032 O and O 2020JJA170017 B-AWARD This O work O was O supported O by O theEuropean O Community’s I-ORG Seventh I-ORG Framework I-ORG Programme(FP7/2007-2013 O under O EC-GA O no. O 241642 O PAM O was O also O supported O by O a O Commonwealth O PhD O Fellowship O AME O by O aWelcome O Trust I-ORG Senior I-ORG Fellowship(grant O number O 095778 B-AWARD SC O byWellcome O Trustfunding O grant O number O 084344 B-AWARD and O PAM O and O SC O by O an O MRC O project O grant O MR/K019708 O This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG of I-ORG China O grant O no. O 2016YFB0700302 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O nos O 51771232 B-AWARD and O 51604112 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG of I-ORG China O grant O no. O 2017JJ3089 B-AWARD and O the O Project O of O Innovation O and O Entrepreneur O Team O Introduced O by O Guangdong O Province O of O China O grant O no. O 201301G0105337290 B-AWARD This O work O was O supported O by O the O Guangzhou B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Program-Technology I-ORG Benefiting I-ORG Special I-ORG No.2014Y2-00031 O the O Collaborative B-ORG Innovation I-ORG major I-ORG projects I-ORG of I-ORG Guangzhou I-ORG health I-ORG care I-ORG No.201400000002 O the O Science O Research O Project O of O Guangdong O Province O No.2013B020224006 O and O the O Youth B-ORG Scientific I-ORG Research I-ORG Funds I-ORG of I-ORG First I-ORG Affiliated I-ORG Hospital I-ORG of I-ORG Guangzhou I-ORG Medical I-ORG University I-ORG No.201220-gyfyy O This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0806007 O the B-ORG National I-ORG Science I-ORG Fund I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG 51425801 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51808081 O the O Science O and O Technology O Research O Program O of O Chongqing O Municipal O Education O Commission O of O China O KJQN201800701 O the O Science O and O Technology O Research O Project O of O Chongqing O Science O O Technology O Bureau O of O China O cstc2017rgzn-zdyfX0018 O cstc2018jscx-mszdX0084 O and O the O Innovation O Fund O Project O of O Graduate O Education O of O Chongqing O Jiaotong O University O 2019S0156 O 2019S0154 O This O study O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 51706178 B-AWARD 81171317 B-AWARD 81971581 B-AWARD National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0100300 O the O 2011 B-ORG New I-ORG Century I-ORG Excellent I-ORG Talent I-ORG Support I-ORG Plan I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG China I-ORG NCET-11-0438 O All O authors O read O and O approved O the O final O manuscript O This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG nos O 21471103 B-AWARD 51002180 I-AWARD 11275218 I-AWARD and I-AWARD 11574173 O National B-ORG Basic I-ORG Research I-ORG Programs I-ORG of I-ORG China I-ORG nos O 2016YFA0201603 B-AWARD 2015CB932104 O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG no. O 2162046 B-AWARD and O the O General B-ORG Program I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Project I-ORG of I-ORG Beijing I-ORG Municipal I-ORG Commission I-ORG of I-ORG Education I-ORG no. O KM201410028021 B-AWARD and O the O Scientific B-ORG Research I-ORG Base I-ORG Development I-ORG Program I-ORG of I-ORG the I-ORG Beijing I-ORG Municipal I-ORG Commission I-ORG of I-ORG Education I-ORG no. O 203175302200 B-AWARD This O research O was O funded O by O the O 863 O Program O 2016YFA0301300 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61671090 O 61875021 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Beijing I-ORG Municipality I-ORG 2192036 O the O China B-ORG Scholarship I-ORG Council I-ORG CSC O 201706470049 O the O Beijing B-ORG University I-ORG of I-ORG Posts I-ORG and I-ORG Telecommunications I-ORG Excellent O Ph.D O Foundation O CX2017302 O and O the O Defense B-ORG Threat I-ORG Reduction I-ORG Agency I-ORG HDTRA1-18-1-0044 O C.L O is O supported O by O a O DeMund O Foundation O Graduate O Student O Endowed O Scholarship O in O Optical O and O Medical O Sciences O Friends O of O Tucson O Optics O FOTO O Scholarship O from O the O University O of O Arizona O This O study O was O supported O by O Hainan B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 2017CXTD010 B-AWARD the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81760465 B-AWARD and O 81460450 B-AWARD the O Finance B-ORG science I-ORG and I-ORG technology I-ORG project I-ORG of I-ORG Hainan I-ORG province I-ORG Grant O No. O ZDYF2019163 B-AWARD and O ZDKJ2017007 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Key I-ORG Program I-ORG for I-ORG Research I-ORG and I-ORG Development I-ORG 2016YFD0100202 O Chinese B-ORG Academy I-ORG of I-ORG agricultural I-ORG sciences I-ORG special I-ORG Project I-ORG for I-ORG basic I-ORG research I-ORG Y2016PT35 O and O National B-ORG Infrastructure I-ORG for I-ORG Crop I-ORG Germplasm I-ORG Resources I-ORG NICGR2017-014 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O U1604115 O National B-ORG Program I-ORG on I-ORG Key I-ORG R I-ORG I-ORG D I-ORG Project I-ORG No. O 2016YFD0401005 O Key B-ORG Technologies I-ORG R I-ORG I-ORG D I-ORG Program I-ORG of I-ORG the I-ORG Education I-ORG Department I-ORG of I-ORG Henan I-ORG Province I-ORG No. O 16A210017 O and O the O Collaborative O Innovation O Center O of O Grain O Storage O and O Security O in O Henan O Province O to O JL. O This O work O was O supported O by O the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG China I-ORG 863 I-ORG project I-ORG Grant O No. O 2013AA102207 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31471622 B-AWARD Zhejiang B-ORG Province I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O LY14C200010 B-AWARD and O Fund B-ORG of I-ORG Fuli I-ORG Institute I-ORG of I-ORG Food I-ORG Science I-ORG Zhejiang I-ORG University I-ORG KY201401 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O in O part O by O research O grants O from O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Guangzhou I-ORG 201604020001 O Guangzhou B-ORG Science I-ORG Technology I-ORG and I-ORG Innovation I-ORG Commission I-ORG 201607010162 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81570633 O The O fund O was O mainly O used O for O microarray O analysis O and O examinations O of O subjects O in O study O such O as O CT O scan O and O chemical O composition O of O urinary O stones O This O work O was O supported O by O funds O from O the B-ORG Public I-ORG Welfare I-ORG Agricultural I-ORG Scientific I-ORG Research I-ORG 201203065 O Key B-ORG Laboratory I-ORG of I-ORG Freshwater I-ORG Animal I-ORG Breeding I-ORG in I-ORG Ministry I-ORG of I-ORG Agriculture I-ORG 2015PY076 O and O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG for I-ORG Young I-ORG Scientists I-ORG 31302169 O This O study O was O supported O by O grants O 82273204 B-AWARD 81972471 B-AWARD and O 82073408 B-AWARD from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O 2023A1515012412 B-AWARD and O 2023A1515011214 B-AWARD GuangDong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation O grant O 202206010078 B-AWARD and O 202201020574 B-AWARD from O the O Guangzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Project O grant O 2018007 B-AWARD from O the O Sun B-ORG Yat-Sen I-ORG University I-ORG Clinical I-ORG Research I-ORG 5010 I-ORG Program O grant O SYS-C-201801 B-AWARD from O the O Sun B-ORG Yat-Sen I-ORG Clinical I-ORG Research I-ORG Cultivating I-ORG Program O grant O A2020558 B-AWARD from O the O Guangdong B-ORG Medical I-ORG Science I-ORG and I-ORG Technology I-ORG Program O grant O 7670020025 B-AWARD from O Tencent B-ORG Charity I-ORG Foundation O grant O YXQH202209 B-AWARD from O the O Scientific B-ORG Research I-ORG Launch I-ORG Project I-ORG of I-ORG Sun I-ORG Yat-Sen I-ORG Memorial I-ORG Hospital I-ORG This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 51705130 B-AWARD and O in O part O by O the O Science B-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province O grant O number O E2016208084 B-AWARD and O the O Education B-ORG Department I-ORG of I-ORG Hebei I-ORG Province O grant O number O CXZZSS2019091 B-AWARD This O study O was O funded O by O the O British B-ORG Council I-ORG and O Egyptian O Ministry O of O Higher O Education O Newton-Mosharafa O PhD O Programme O for O a O studentship O to O support O H.A.M.A O Grant O Reference O NMM28/20 B-AWARD the O UK O Royal B-ORG Society I-ORG for O financial O support O Grant O reference O RG160449 B-AWARD A103355 B-AWARD to O J.G.H O and O North B-ORG West I-ORG Cancer I-ORG Research I-ORG NWCR O for O financial O support O to O N.A.C O NWCR O DTP O NWCRCD2020.21 B-AWARD This O research O was O funded O by O grants O from O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG grant O number O 2021YFA1301000 B-AWARD Research B-ORG Project I-ORG of I-ORG Jinan I-ORG Microecological I-ORG Biomedicine I-ORG Shandong I-ORG Laboratory I-ORG grant O number O JNL-2022013B B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 32170068 B-AWARD This O work O was O supported O by O the O “Russian O Science I-ORG Foundation” O http://rscf.ru O 15-14-20011 O to O I.V.S O the O “Agence O Nationale I-ORG de I-ORG la I-ORG Recherche” O https://anr.fr O ANR-17-CE12-0030 O EpiTET I-AWARD to O E.B O and O C.V O the O “Fondation O ARC I-ORG pour I-ORG la I-ORG Recherche I-ORG sur I-ORG le I-ORG Cancer” O https://www.fondation-arc.org O PJA O 20171206129 I-AWARD to O E.B O and O the O French O government O IDEX-ISITE O initiative O https://www.gouvernement.fr/idex-isite O 16-IDEX-0001 O CAP20-25 O to O E.B O This O research O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 61434007 B-AWARD and I-AWARD 61504100 O the O Foundation B-ORG for I-ORG Fundamental I-ORG Research I-ORG of I-ORG China I-ORG Grant O No. O JSZL2016110B003 B-AWARD and O the O Major B-ORG Fundamental I-ORG Research I-ORG Program I-ORG of I-ORG Shaanxi I-ORG Grant O No. O 2017ZDJC-26 B-AWARD This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC1502405 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51709071 O and O 51579059 B-AWARD and O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG of I-ORG China I-ORG 2017GSF20101 O This O study O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 30972080 B-AWARD 31272408 I-AWARD 31600617 O the B-ORG Program I-ORG of I-ORG the I-ORG National I-ORG Beef I-ORG Cattle I-ORG Industrial I-ORG Technology I-ORG System I-ORG CARS-38 O the B-ORG National I-ORG 863 I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2013AA102505 B-AWARD and O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK2011206 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O made O available O to O P.G O Flight O Attendant I-ORG Medical I-ORG Research I-ORG Institute I-ORG CIA160005 O and O the O Alpha-1 B-ORG Foundation I-ORG 614218 O Medical O Research O Council O MR/P022847/1 O C.T./S.W O Rosetrees B-ORG Trust I-ORG A2450 O C.T./S.W O and O the O Cystic B-ORG Fibrosis I-ORG Foundation I-ORG WELDON18G0 O This O work O was O supported O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81473346 O 81573595 B-AWARD and O 81673593 B-AWARD CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG CIFMS I-ORG 2016-I2M-3-010 O and O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 7152101 O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81570561 O to O HL O Hang O Shanghai B-ORG Pujiang I-ORG Program I-ORG 17PJD023 O to O HL O Hang O Shanghai B-ORG Municipal I-ORG Education I-ORG Commission--Gaofeng I-ORG Clinical I-ORG Medicine I-ORG Grant I-ORG Support I-ORG 20181806 O to O HL O Hang O and O The B-ORG Most I-ORG Important I-ORG Clinical I-ORG Medical I-ORG Center I-ORG in I-ORG Shanghai I-ORG 2017ZZ01018 O to O Q O Xia O This O research O was O funded O by O the O Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund O grant O number O HRFRI B-AWARD HSY202202M O the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG of I-ORG MOF I-ORG and I-ORG MARA O grant O number O CARS-46 B-AWARD the O Key B-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG Heilongjiang I-ORG Province O grant O number O JD22A017 B-AWARD the O National B-ORG Postdoctoral I-ORG Fund O grant O number O 2022MD713817 B-AWARD and O the O China B-ORG Scholarship I-ORG Council O grant O number O 202003260012 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O U1860201 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG grant O number O 2018M631804 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG grant O number O N170703005 B-AWARD We O thank O support O from O the O grants O of O National B-ORG Key I-ORG R I-ORG I-ORG D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC1309601 O for O Fang O Liu O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81770802 O for O Fang O Liu O Shanghai B-ORG Science I-ORG I-ORG Technology I-ORG Pillar I-ORG Program I-ORG in I-ORG the I-ORG Field I-ORG of I-ORG Medicine I-ORG and I-ORG Agriculture I-ORG 15411953100 O to O Fang O Liu O and O Shanghai B-ORG Municipal I-ORG Education I-ORG Commission-Gaofeng I-ORG Clinical I-ORG Medicine I-ORG Grant I-ORG Support I-ORG 20152232 O This O research O was O funded O by O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017B020207005 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2015A030312001 O and O Guangzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG key I-ORG projects I-ORG 201704020037 O The O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 31271927 B-AWARD by O the O Key B-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shandong I-ORG Project O 2016GNC110015 B-AWARD and O by O Shandong B-ORG Province I-ORG Quality I-ORG Core I-ORG Curriculum I-ORG of I-ORG Postgraduate I-ORG Education I-ORG SDYY18117 O This O study O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81500694 B-AWARD Zhejiang B-ORG Key I-ORG Laboratory I-ORG Fund I-ORG of I-ORG China I-ORG No. O 2011E10006 B-AWARD Zhejiang B-ORG Province I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG No. O 2015C03042 B-AWARD This O work O was O funded O by O the O Human B-ORG Frontier I-ORG Science I-ORG Program O grant O no. O RGY83/2012 B-AWARD to O M.E.H O T.G O and O M.D.S O Air B-ORG Force I-ORG Office I-ORG of I-ORG Scientific I-ORG Research O grant O no. O FA9550-16-1-0331 B-AWARD to O M.D.S O and O the O European B-ORG Social I-ORG Fund I-ORG and I-ORG the I-ORG state I-ORG budget I-ORG of I-ORG the I-ORG Czech I-ORG Republic O project O no. O CZ.1.07/2.3.00/30.0041 B-AWARD to O D.H O and O T.G O This O work O was O supported O by O fundings O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31672170 O and I-AWARD 31872950 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG JQ201309 O the O Shandong B-ORG “Double I-ORG Tops” I-ORG Program I-ORG SYL2017YSTD06 O and O the O ‘Taishan B-ORG Scholar’ I-ORG Foundation I-ORG of I-ORG the I-ORG People’s I-ORG Government I-ORG of I-ORG Shandong I-ORG Province I-ORG ts20130932 O The O funds O played O no O role O in O study O design O data O analysis O and O manuscript O preparation O This O work O was O supported O in O part O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG of I-ORG China I-ORG under O Grant O 2017YFB1002502 B-AWARD in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O 61701089 B-AWARD 62106285 B-AWARD and O in O part O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Henan I-ORG Province I-ORG of I-ORG China I-ORG under O Grant O 162300410333 B-AWARD This O study O was O supported O by O a O joint O project O funded O by O the O Natural B-ORG Sciences I-ORG and I-ORG Engineering I-ORG Research I-ORG Council I-ORG of I-ORG Canada I-ORG collaborative O research O and O development O grant O EQPEQ/421963-2012 O Alberta B-ORG Livestock I-ORG and I-ORG Meat I-ORG Agency I-ORG Alberta O Agriculture O and O Forestry O grant O 2011R037R O and O Canadian B-ORG Poultry I-ORG Research I-ORG Council I-ORG grant O AMN048 O This O study O was O supported O by O the O grants O from O the O Chinese B-ORG National I-ORG 973 I-ORG Program I-ORG 2015CB554300 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31670172 O and O the B-ORG Strategic I-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDPB03 O to O JZ. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Innovative B-ORG Research I-ORG Team I-ORG Grant I-ORG of I-ORG the I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Hainan I-ORG Province I-ORG No.2017CXTD020 O Major B-ORG Technology I-ORG Project I-ORG of I-ORG Hainan I-ORG Province I-ORG ZDKJ2016004-03 O Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG for I-ORG Innovative I-ORG Research I-ORG Team I-ORG Program I-ORG of I-ORG CATAS I-ORG 17CXTD-15 O and O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-21 O This O study O was O funded O by O the B-ORG Hefei I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG Fund I-ORG under O grant O number O J2020Y01 B-AWARD the O Open O Fund O of O Key B-ORG Laboratory I-ORG of I-ORG Anti-inflammatory I-ORG and I-ORG Immune I-ORG Medicine I-ORG Ministry I-ORG of I-ORG Education I-ORG P.R I-ORG China I-ORG Anhui O Medical O University O under O grant O number O KFJJ-2023-09 B-AWARD and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG under O grant O number O WK9110000188 B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 31460669 B-AWARD and O 31660714 B-AWARD National B-ORG major I-ORG research I-ORG and I-ORG development I-ORG projects I-ORG grant O no.2016YFD0500300 O and O Special B-ORG Fund I-ORG for I-ORG Agro-scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG grant O no. O 201303035 B-AWARD This O study O was O supported O by O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health I-ORG K23 O MH092648 O National B-ORG Center I-ORG for I-ORG Research I-ORG Resources I-ORG UL1 O RR024986 O and O National B-ORG Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences I-ORG 2UL1 O TR000433 O All O authors O report O no O biomedical O financial O interests O related O to O this O work O in O the O past O or O in O the O foreseeable O future O The B-ORG National I-ORG Key I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2015BAD07B0104 O the B-ORG Jiangsu I-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG BE2016388 O and O the B-ORG Jiangsu I-ORG Province I-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Fund I-ORG Project I-ORG CX(14)2029 O funded O this O work O Yangzhou O Crabapple O Horticulture O Company O Limited O provided O support O in O the O form O of O salaries O for O author O WZ, O but O did O not O have O any O additional O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O specific O roles O of O this O author O WZ) O is O articulated O in O the O author O contributions O section O The O work O was O partially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 11547006 O 11471133 O Scientific B-ORG Research I-ORG Project I-ORG of I-ORG Hubei I-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG B2017039 O Undergraduate B-ORG Training I-ORG Program I-ORG of I-ORG Yangtze I-ORG University I-ORG for I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG 20150094 O The O funding O body O had O no O role O in O the O study O design O collection O analysis O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG for I-ORG Higher I-ORG Education I-ORG Institutions I-ORG in I-ORG Jiangsu I-ORG Province I-ORG 21KJB210007 O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Jiangsu I-ORG BE2022386 O and O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG Project I-ORG PAPD O This O work O was O supported O by O a O grant O from O the B-ORG Science I-ORG and I-ORG Technology I-ORG R I-ORG I-ORG D I-ORG Fund I-ORG of I-ORG Shenzhen I-ORG No. O JCYJ20170307104838077 O the B-ORG Medical I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O B2018150 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81472275 O and O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG No.2014A030313542 O They O played O an O important O role O in O research O design O analyzing O and O interpreting O data O and O paper O writing O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFE0122500 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41771469 O and I-AWARD 41571323 O the O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 6182011 O the O Beijing B-ORG Academy I-ORG of I-ORG Agriculture I-ORG and I-ORG Forestry I-ORG Sciences I-ORG KJCX20170423 O and O the O Special B-ORG Funds I-ORG for I-ORG Technology I-ORG innovation I-ORG capacity I-ORG platform I-ORG building I-ORG sponsored I-ORG by I-ORG the I-ORG Beijing I-ORG Academy I-ORG of I-ORG Agriculture I-ORG and I-ORG Forestry I-ORG Sciences I-ORG PT2019-29 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O a O Wellcome B-ORG Trust I-ORG programme O grant O grant O number O 075945 B-AWARD a O Wellcome B-ORG Trust I-ORG project I-ORG grant O grant O number O 093113 B-AWARD and O the O Wellcome B-ORG Trust I-ORG Institutional I-ORG Strategic I-ORG Support I-ORG Fund I-ORG grant O number O 105610 B-AWARD J.K O is O supported O by O the O Leeds O NIHR O Musculoskeletal O Biomedical O Research O Unit O Funding O to O pay O the O Open O Access O publication O charges O for O this O article O was O provided O by O the O Wellcome O Trust O UK. O This O study O was O supported O by O the O Ministerio O de O Economía O y O Competitividad O AGORA B-ORG project I-ORG CGL2016–77417–P—Spanish O Government O REMEDINAL B-ORG project I-ORG TE-CM O S2018/EMT-4338—Madrid O Regional O Government O Ministerio O de O Ciencia O e O Innovación O PHENOTYPES B-ORG project I-ORG PGC2018-099115-B-I00-P—Spanish O Government O and O GYPWORLD B-ORG project I-ORG H2020-MSCA-RISE-2017-777803—European O Commission O ADDITION-Cambridge O was O supported O by O the O Wellcome B-ORG Trust I-ORG Grant O Reference O No: O G061895 B-AWARD the O Medical B-ORG Research I-ORG Council I-ORG Grant O Reference O No: O G0001164 B-AWARD and O Epidemiology O Unit O programme O MC_UU_12015/4 B-AWARD the O NIHR B-ORG Health I-ORG Technology I-ORG Assessment I-ORG Programme I-ORG Grant O Reference O no: O 08/116/300 B-AWARD NIHR B-ORG Programme I-ORG Grants I-ORG for I-ORG Applied I-ORG Research I-ORG RP-PG-0606-1259 O National O Health O Service O R&D O support O funding O including O the O Primary O Care O Research O and O Diabetes O Research O Networks O and O the O National O Institute O for O Health O Research O SJG O is O an O NIHR O Senior O Investigator O The O University O of O Cambridge O has O received O salary O support O in O respect O of O SJG O from O the O NHS O in O the O East O of O England O through O the O Clinical O Academic O Reserve O This O work O was O funded O by O the O National B-ORG Key I-ORG Technology I-ORG R&D I-ORG Program I-ORG 2015BAD03B02-8 O the O Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG China I-ORG ZR2015CQ011 O the O Agricultural B-ORG Elite I-ORG Breeds I-ORG Project I-ORG of I-ORG Shandong I-ORG Province I-ORG 2015 I-ORG and I-ORG the I-ORG Funds I-ORG of I-ORG Shandong I-ORG “Double I-ORG Tops” I-ORG Program I-ORG SYL2017YSTD12 O Open O Access O funding O is O provided O by O Projekt O DEAL O The O work O was O supported O by O the O Marie B-ORG Curie I-ORG Initial I-ORG Training I-ORG Network I-ORG PROSENSE O grant O no. O 317420 B-AWARD 2012−2016,www.prosense-itn.eu O V.P O received O industrial O support O for O the O funding O of O his O position O from O the O EUROIMMUN O Medizinische O Labordiagnostika O AG O in O Lübeck O Germany O and O from O the O Stiftung B-ORG Rheinland-Pfalz I-ORG für I-ORG Innovation I-ORG grant O no. O 1082 B-AWARD M.S.S O received O the O Margarete B-ORG von I-ORG Wrangell I-ORG MvW O 31-7635.41/118/3 B-AWARD habilitation O scholarship O co-funded O by O the O Ministry O of O Science O Research O and O the O Arts O MWK O of O the O state O of O Baden-Württemberg O and O by O the O European O Social O Funds O This O work O was O supported O by O the O National B-ORG Program I-ORG on I-ORG Key I-ORG Research I-ORG Project I-ORG of I-ORG China I-ORG 2016YFC0902700 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81472515 O and I-AWARD 91229103 O and O the O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG 18DZ2291500 O Wanjun O Chen O is O supported O by O the O Intramural O Research O Program O of O NIDCR O NIH O The O research O of O S. O Won O was O supported O by O the O Bio-Synergy O Research O Project O NRF-2017M3A9C4065964 O of O the O Ministry B-ORG of I-ORG Science I-ORG ICT I-ORG and I-ORG Future I-ORG Planning I-ORG through I-ORG the I-ORG National I-ORG Research I-ORG Foundation O The O research O of O YJ O Kim O was O supported O by O the O Ministry B-ORG of I-ORG Education I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Korea I-ORG No. O 2012M3A9C4048761 B-AWARD The O research O of O C. O Park O was O supported O by O Basic O Science O Research O Program O through O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea(NRF O funded O by O the O Ministry O of O Education O No. O 2015R1D1A1A01059984 B-AWARD This O research O was O funded O by O the O Fundamental O Research O Funds O of O the O Central O Universities O in O China O for O the O startup O funding O received O from O Hunan B-ORG University I-ORG 531118010366 O the O partial O support O received O from O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG 2021JJ30100 O and O National B-ORG Social I-ORG Science I-ORG Fund I-ORG 22FYYB033 O to O the O corresponding O author O The B-ORG major I-ORG Scientific I-ORG and I-ORG Technological I-ORG Project I-ORG of I-ORG Henan I-ORG Province O 221100110600 B-AWARD Project O funded O by O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation O 2021M690926 B-AWARD Natural O Science I-ORG Foundation I-ORG of I-ORG Henan I-ORG Province O 222300420460 B-AWARD This O work O was O supported O by O the O Medical B-ORG Research I-ORG Council I-ORG MC_UU_12013/4 O and O MC_UU_12013/8 B-AWARD This O work O was O supported O in O part O by O the O Cancer B-ORG Research I-ORG UK I-ORG Programme I-ORG grant O C18281/A19169 B-AWARD the O Integrative O Cancer O Epidemiology O Programme O P.C.H O is O a O Cancer B-ORG Research I-ORG UK I-ORG Population I-ORG Research I-ORG Fellow I-ORG grant O C52724/A20138 B-AWARD T.G.R O is O a O UKRI B-ORG Innovation I-ORG Research I-ORG Fellow I-ORG MR/S003886/1 O This O work O was O supported O by O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O contract O nos O 51802177 B-AWARD and O 11804194 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG under O grant O no. O ZR2019MA020 B-AWARD and O the O Research O Start-up O Funds O of O Shandong B-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG no. O 415058 B-AWARD This O work O was O supported O by O the O Medical B-ORG Project I-ORG of I-ORG Fujian I-ORG Province I-ORG 2016-CX-33 O Fujian B-ORG Province I-ORG Health I-ORG Youth I-ORG Research I-ORG Project I-ORG 2019-1-37 O and O Fujian B-ORG Medical I-ORG University I-ORG Sailing I-ORG Fund I-ORG Project I-ORG 2018QH1047 B-AWARD The O funders O had O no O role O in O study O design O d O conduct O and O outcome O of O the O manuscript O No O additional O external O funding O was O received O for O this O study O This O study O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC1314100 O the O Key-Area B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province[2019B020230001 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M640871 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Youth I-ORG Science I-ORG Foundation I-ORG 81802222 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2018A030310694 O the O Basic B-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2020A1515010268 O the O Guangdong B-ORG Medical I-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Foundation I-ORG 2018114214430383 O the O Foundation B-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG of I-ORG Guangdong I-ORG Province I-ORG 20191004 O the O Scientific B-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Provincial I-ORG People’s I-ORG Hospital I-ORG 2017bp01 O the O Outstanding B-ORG Young I-ORG Talents I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Provincial I-ORG People’s I-ORG Hospital I-ORG KJ012019091 O and O Program B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Guangzhou I-ORG 201904010424 O Work O in O the O authors’ O laboratory O has O been O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31702186 O and O 31872425 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG China O BK20160509 O and O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2016M601725 O This O research O was O supported O by O theBritish O Lung I-ORG Foundation(R914-6);Cancer O Research I-ORG UK(C5759/A12328 O theManchester O CRUK I-ORG Experimental I-ORG Cancer I-ORG Medicine I-ORG Centre(C1467/A15578 O theManchester O Cancer I-ORG Research I-ORG Centre(A12197);CRUK O Lung I-ORG Cancer I-ORG Centre I-ORG of I-ORG Excellence(C5759/A20465);European O Union I-ORG CHEMORESFP6 O LSHG-CT-2007-037665 O and O travel O grants O to O Guilia O Bertonlini O from O Associazione O Italiana O Ricerca O Cancro O Accademia O Nazionale O dei O Lincei O and O Progetto O Professionalità_Fondazione O Banca O del O Monte O della O Lombardia O This O work O is O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51705477 B-AWARD No. O 61603353 B-AWARD and O No. O 61703098 B-AWARD and O Pre-Research B-ORG Field I-ORG Foundation I-ORG of I-ORG Equipment I-ORG Development I-ORG Department I-ORG of I-ORG China I-ORG No. O 61405170104 B-AWARD The O research O is O also O supported O by O program O for O the O Top O Young O Academic O Leaders O of O Higher O Learning O Institutions O of O Shanxi O Fund O Program O for O the O Scientific O Activities O of O Selected O Returned O Overseas O Professionals O in O Shanxi O Province O Shanxi B-ORG Province I-ORG Science I-ORG Foundation I-ORG for I-ORG Youths I-ORG No. O 201801D221195 B-AWARD Young O Academic O Leaders O of O North O University O of O China O No. O QX201809 B-AWARD Fund O of O Science O and O Technology O on O Electronic O Test O O Measurement O Laboratory O No. O WD614200104011804 O the O Open O Fund O of O State O Key O Laboratory O of O Deep O Buried O Target O Damage O No. O DXMBJJ2017-15 B-AWARD and O No. O DXMBJJ2018-07 B-AWARD and O the O Fund O for O Shanxi O “1331 O Project” O Key O Subjects O Construction O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 42007131 O Natural B-ORG Science I-ORG Research I-ORG Project I-ORG of I-ORG Higher I-ORG Education I-ORG in I-ORG Jiangsu I-ORG Province I-ORG 20KJB610004 O and O National B-ORG and I-ORG Local I-ORG Joint I-ORG Engineering I-ORG Laboratory I-ORG for I-ORG Municipal I-ORG Sewage I-ORG Resource I-ORG Utilization I-ORG Technology I-ORG Suzhou I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2021KF02 O This O research O was O funded O by O Consejo B-ORG Superior I-ORG de I-ORG Investigaciones I-ORG Científicas I-ORG CSIC O grant O number O I-LINK1200 B-AWARD Ministerio B-ORG de I-ORG Ciencia I-ORG e I-ORG Innovación I-ORG de I-ORG España I-ORG and I-ORG European I-ORG Union I-ORG NextGeneration I-ORG EU/PRTR O grant O numbers O PCI2020-112039 B-AWARD MCIN/AEI-10.13039/501100011033 O PID2020-115334GB-I00 B-AWARD MCIN/AEI-10.13039/501100011033 I-AWARD and O PID2020-113001RB-I00 B-AWARD MCIN/AEI-10.13039/501100011033 O Principado B-ORG de I-ORG Asturias I-ORG FICYT)–European I-ORG Union I-ORG FEDER O grant O number O PCTI-Asturias B-AWARD IDI/2021/000015 O and O Czech B-ORG Science I-ORG Foundation O grant O number O 20-03899S B-AWARD S.L.F.-L O acknowledges O her O predoctoral O grant O from O the O Severo O Ochoa O Program O awarded O by O Principado O de O Asturias O J.A.M O and O M.A.M.-M O are O members O of O the O CSIC O Interdisciplinary O Thematic O Platform O PTI O for O Sustainable O Plastics O towards O a O Circular O Economy O PTI-SusPlast O This O research O is O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 11602073 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG of O China O QC2018005 O and O the O research O is O also O supported O by O “the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities” O Grant O No.HIT.NSRIF.201821 O And O APC O was O funded O by O Natural O Science O Foundation O of O Heilongjiang O Province O of O China O QC2018005 O This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Beijing I-ORG Municipality I-ORG Beijing O Natural O Science O Foundation)(No.7162124 O which O supported O design O analysis O and O the O interpretation O of O data O in O this O study O and O the B-ORG Collaborative I-ORG Innovation I-ORG Project I-ORG of I-ORG the I-ORG Beijing I-ORG University I-ORG of I-ORG Chinese I-ORG Medicine I-ORG No.522/0100604299 O and O the O XinAo B-ORG Awarding I-ORG Foundation I-ORG of I-ORG the I-ORG Beijing I-ORG University I-ORG of I-ORG Chinese I-ORG Medicine I-ORG No.1000062720044/006 O which O both O provided O the O animals O medicine O and O other O materials O needed O in O the O study O This O work O was O supported O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0601002 O Collaborative B-ORG Innovation I-ORG for I-ORG “Juncao” I-ORG Ecology I-ORG Industry O China O K80ND8002-JCZXGGKT05 O University B-ORG S I-ORG I-ORG T I-ORG Innovation I-ORG Platform I-ORG of I-ORG Jilin I-ORG Province I-ORG for I-ORG Economic I-ORG Fungi I-ORG #2014B-1 O Special B-ORG Fund I-ORG for I-ORG Agro-scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG 201503137 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O 81601650 B-AWARD to O ZR; O Guizhou B-ORG Province I-ORG Engineering I-ORG Technology I-ORG Research I-ORG Center I-ORG Project O Qian B-AWARD High-Tech I-AWARD of I-AWARD Development I-AWARD and I-AWARD Reform I-AWARD Commission I-AWARD NO. I-AWARD 2016]1345 I-AWARD to O JH; O Guizhou B-ORG Province I-ORG Scientific I-ORG and I-ORG Technical I-ORG Foundation O Qian B-AWARD Science I-AWARD LH I-AWARD NO. I-AWARD 2016]7360 I-AWARD to O OW; O Guizhou B-ORG Scientific I-ORG Support I-ORG Project O Qian B-AWARD Science I-AWARD Support I-AWARD 2019 I-AWARD 2825 I-AWARD to O JH; O Guizhou B-ORG Education I-ORG Department I-ORG Young I-ORG Scientific I-ORG and I-ORG Technical I-ORG Talents I-ORG Project O Qian B-AWARD Education I-AWARD KY I-AWARD NO. I-AWARD 2018]199 O Guiyang B-ORG Scientific I-ORG and I-ORG Technical I-ORG Foundation O Guiyang B-AWARD Science I-AWARD NO. I-AWARD 2017 I-AWARD 5-13 O and O Guizhou B-ORG Province I-ORG Scientific I-ORG and I-ORG Technical I-ORG Project O Qian B-AWARD Science I-AWARD SY I-AWARD NO.[2013]3109 I-AWARD to O YZ. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG No. O 2019J01408 B-AWARD the O Outstanding B-ORG Young I-ORG Scientist I-ORG Program I-ORG of I-ORG Fujian I-ORG Agriculture I-ORG and I-ORG Forestry I-ORG University I-ORG No. O xjq201916 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31772684 B-AWARD and O the O Earmarked B-ORG Fund I-ORG for I-ORG Modern I-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG No. O CARS-44-KXJ4 B-AWARD The O funding O body O provided O financial O support O and O had O no O role O in O the O design O of O the O study O collection O analysis O interpretation O of O data O or O writing O the O manuscript O This O study O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0908700 O 2017YFC0908703 O National B-ORG S&T I-ORG Fundamental I-ORG Resources I-ORG Investigation I-ORG Project I-ORG 2018FY100600 O 2018FY100602 O Taishan B-ORG Pandeng I-ORG Scholar I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG tspd20181220 O Taishan B-ORG Young I-ORG Scholar I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG tsqn20161065 O tsqn201812129 B-AWARD and O Key B-ORG R&D I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG 2016ZDJS07A14 O 2018GSF118003 B-AWARD which O provided O financial O support O for O the O collection O analysis O and O interpretation O of O data O This O research O was O supported O by O the O European B-ORG Research I-ORG Council I-ORG Synergy I-ORG grant I-ORG ERC-2013-SyG-610028 B-AWARD IMBALANCE-P O the O Spanish B-ORG Government I-ORG grants I-ORG CGL2013-48074-P O CTQ2012-32436 B-AWARD and O the O Catalan O Government O grant O SGR O 2014-274 O the O Scholarly B-ORG Studies I-ORG program I-ORG of I-ORG the I-ORG Smithsonian I-ORG Institution O the O projects O M200871201 B-AWARD Academy O of O Sciences O of O the O Czech O Republic O and O LO1415 O Ministry O of O Education O Youth O and O Sports O of O the O Czech O Republic O This O project O was O supported O by O the B-ORG Inner I-ORG Mongolia I-ORG Autonomous I-ORG Region I-ORG Tumor I-ORG Biotherapy I-ORG Collaborative I-ORG Innovation I-ORG Center I-ORG No. O 2016ZLXT009 B-AWARD the B-ORG Inner I-ORG Mongolia I-ORG Autonomous I-ORG Region I-ORG University I-ORG Innovation I-ORG Research I-ORG Team I-ORG project I-ORG NMGIRT-A1604 O and O the B-ORG Inner I-ORG Mongolia I-ORG Autonomous I-ORG Region I-ORG Youth I-ORG Science I-ORG and I-ORG Technology I-ORG Talent I-ORG Support I-ORG plan I-ORG NJYT-14-A11 O This O study O was O supported O by O a O Global B-ORG Research I-ORG Laboratory I-ORG Grant I-ORG K21004000003-12A0500-00310 O and O the B-ORG Bio I-ORG I-ORG Medical I-ORG Technology I-ORG Development I-ORG Program I-ORG Fund I-ORG of I-ORG the I-ORG National I-ORG Research I-ORG Foundation I-ORG NRF-2015M3A9B6073846 O Myung-Shik O Lee O is O the O recipient O of O the O Ulsan B-ORG National I-ORG Institute I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Fund I-ORG 2014M3A9D8034459 O Kyu O Yeon O Hur O is O the O recipient O of O grants O from O the O National O Research O Foundation O NRF-2015R1C1A2A01053336 O Samsung B-ORG Medical I-ORG Center I-ORG #CRP1500058 O and O the B-ORG Korean I-ORG Diabetes I-ORG Association I-ORG K.Y O H., I-AWARD 2009 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG Fujian I-ORG Province I-ORG 2016NZ0001 O the O Program O for O New O Century O Excellent O Talents O in O Fujian O Province O KLa17073A O Agricultural B-ORG technology I-ORG extension I-ORG service I-ORG system I-ORG for I-ORG edible I-ORG fungus I-ORG industry I-ORG in I-ORG Fujian I-ORG China I-ORG KNJ-153011-1 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31670021 O These O funding O bodies O had O no O role O in O the O design O of O the O study O collection O analysis O and O interpretation O of O data O or O in O writing O the O manuscript O This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2022YFD1700504 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 21977023 O No. B-AWARD 31860515 O the B-ORG Post-subsidy I-ORG project I-ORG of I-ORG the I-ORG National I-ORG Key I-ORG Research I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018-5262 O the B-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-23-C07 O Program B-ORG of I-ORG Introducing I-ORG Talents I-ORG to I-ORG Chinese I-ORG Universities I-ORG D20023 O and O Major B-ORG Supported I-ORG Project I-ORG of I-ORG Foreign I-ORG Experts I-ORG 110000210820228008 O This O research O was O partly O funded O by O the O Albert B-ORG and I-ORG Anneliese I-ORG Konanz I-ORG Foundation O the O Federal O Ministry O of O Education O and O Research B-ORG Germany I-ORG in I-ORG the I-ORG project I-ORG M2Aind-DeepLearning I-ORG 13FH8I08IA O and O the B-ORG German I-ORG Research I-ORG Foundation I-ORG under O grant O INST874/9-1 B-AWARD Research O in O our O laboratory O is O funded O by O the O Czech B-ORG Science I-ORG Foundation I-ORG CSF/GAČR O European B-ORG Union I-ORG H2020 O and O the O Grant B-ORG Agency I-ORG of I-ORG the I-ORG University I-ORG of I-ORG South I-ORG Bohemia I-ORG in I-ORG České I-ORG Budějovice I-ORG GAJU O European O Union’s O Horizon B-ORG 2020 I-ORG research O and O innovation O programme O 654039 O the O Wellcome B-ORG Trust I-ORG 108433/Z/15/Z O the O Biotechnology B-ORG and I-ORG Biosciences I-ORG Research I-ORG Council I-ORG BB/L024136/1 O the O European O Molecular O Biology O Laboratory O core O funds O the O European B-ORG Cooperation I-ORG in I-ORG Science I-ORG and I-ORG Technology I-ORG COST O Action O BM1405 O NGP-net O the O National O Human O Genome O Research O Institute O of O the O US O National B-ORG Institutes I-ORG of I-ORG Health I-ORG R01-HG009116 O to O S.R.E O Funding O for O open O access O charge O the O Wellcome O Trust O and O Research O Councils O UK O RCUK O This O research O was O funded O by O Key O Programs O 2021GY-151 O 2023-JC-YB-674 B-AWARD and O the O Innovation O Capability O Support O Program O 2019TD-019 O funded O by O the O Science B-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG the I-ORG Shaanxi I-ORG Provincial I-ORG Government O the O Key B-ORG R&D I-ORG Program I-ORG of I-ORG Xianyang I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG 2021ZDYF-GY-0029 O the O Natural O and O Scientific O Program O 19JK0572 O 20JK0804,21JK0798 B-AWARD funded O by O the O Education B-ORG Department I-ORG of I-ORG the I-ORG Shaanxi I-ORG Provincial I-ORG Government I-ORG This O research O was O funded O by O National O Key O R&D O Program O of O China O 2017YFA0304203 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 61622503 O 61575113 I-AWARD 61805132 I-AWARD 11434007 O Changjiang B-ORG Scholars I-ORG and I-ORG Inno-vative I-ORG Research I-ORG Team I-ORG in I-ORG University I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG IRT_17R70 O 111 B-ORG project I-ORG D18001 O Outstanding O Innova-tive O Teams O of O Higher O Learning O Institutions O of O Shanxi O Foundation O for O Selected O Young O Scientists O Studying O Abroad O Sanjin O Scholar O 2017QNSJXZ-04 O and O Shanxi O “1331KSC” O Frank O K. O Tittel O acknowledges O support O by O the O Robert O Welch O Foundation O Grant O C0586 O and O NSF O MIRTHE O This O research O was O funded O by O the O Jiangsu B-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Fund I-ORG CX(21)3026 O the O Jiangsu B-ORG seed I-ORG industry I-ORG revitalization I-ORG project I-ORG JBGS[2021]017 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32102368 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG of I-ORG China I-ORG 21KJB210008 O and O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-24 O This O work O was O supported O by O The B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81570879 B-AWARD 81770955 B-AWARD the B-ORG Project I-ORG of I-ORG Shanghai I-ORG Science I-ORG and I-ORG Technology I-ORG Grant O No. O 17411950200 B-AWARD and O 17140902900 B-AWARD and O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG for I-ORG Young I-ORG Scholar I-ORG Grant O No. O 81600762 B-AWARD in O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O Korea O Health O Technology O R&D O Project O HI14C2726 O through O the O Korea B-ORG Health I-ORG Industry I-ORG Development I-ORG Institute I-ORG KHIDI O funded O by O the O Ministry O of O Health O and O Welfare O the O National B-ORG Research I-ORG Council I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG NST O grant O by O the O Korea O government O MSIP O No. O CRC-16-01-KRICT B-AWARD the O Korea B-ORG Basic I-ORG Science I-ORG Institute I-ORG research O program O C38932 O and O UST O Young O Scientist O program O 2018 O The O work O was O financially O supported O by O national B-ORG funds I-ORG FCT/MCTES I-ORG to O CIMO O UIDB/00690/2020 O and O UIDP/00690/2020 B-AWARD and O SusTEC B-ORG LA/P/0007/2021 O We O also O thank O the O FCT O for O the O PhD O grant O of O Filipa O Mandim O SFRH/BD/146614/2019 O The O authorsare O also O grateful O to O FEDER B-ORG for O financial O support O through O the O project O OliveBIOextract O NORTE-01-0247-FEDER-049865 O This O work O is O also O supported O by O MICINN B-ORG supporting O the O Ramón O y O Cajal O grant O for O M.A O Prieto O RYC-2017-22891 O and O Juan O de O la O Cierva O Formation O contract O for O T. O Oludemi O FJC2019-042549-I O and O Tânia O C.S.P O Pires O FJC20120-045405-I O This O work O was O supported O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China O 2016YFC1300300 B-AWARD Prof O Lei O Xu O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG CN O 81641069 B-AWARD and I-AWARD 81271542 I-AWARD Prof O Lei O Xu O and O National B-ORG Heart I-ORG Foundation I-ORG of I-ORG Australia O 101843 B-AWARD Prof O Zhonghua O Sun O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O in O part O by O the O National B-ORG Science I-ORG Foundation I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG of I-ORG China I-ORG No. O 81625016 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81772555 B-AWARD and O 81802352 B-AWARD and O the O Shanghai B-ORG Sailing I-ORG Program I-ORG No. O 17YF1402500 B-AWARD This O work O was O supported O by O Danish B-ORG Agency I-ORG for I-ORG Science I-ORG Technology I-ORG and I-ORG Innovation I-ORG 09-067 O 180 O Danish B-ORG Ministry I-ORG of I-ORG the I-ORG Environment I-ORG CeHoS I-ORG MST-621-00 O 065 O Capital B-ORG Region I-ORG of I-ORG Denmark I-ORG R129-A3966 O Ministry B-ORG of I-ORG Higher I-ORG Education I-ORG and I-ORG Science I-ORG DFF-1331-00 O 113 O Innovation B-ORG Fund I-ORG Denmark I-ORG InnovationsFonden O 14-2013-4 B-AWARD The O International O Center O for O Research O and O Research O Training O in O Endocrine O Disrupting O Effects O of O Male O Reproduction O and O Child O Health O B.H O F.R.D O J.R.B.P O and O K.K.O O are O supported O by O the O Medical B-ORG Research I-ORG Council I-ORG MC_UU_12015/2 O The O 23andMe O study O is O supported O by O the O National B-ORG Human I-ORG Genome I-ORG Research I-ORG Institute I-ORG of I-ORG the I-ORG National I-ORG Institutes I-ORG of I-ORG Health I-ORG R44HG006981 O Members O of O the O 23andMe O Research O Team O are O employees O of O 23andMe O Inc O and O hold O stock O or O stock O options O in O 23andMe O This O work O has O been O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31472272 O the B-ORG National I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG No. O 2012CB722305 O Hunan B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 14JJ2058 O the O Scientific O Research O Fund O of O Hunan O Provincial O Education O Department O No.14FJ4261 O the B-ORG Cooperative I-ORG Innovation I-ORG Center I-ORG of I-ORG Engineering I-ORG and I-ORG New I-ORG Products I-ORG for I-ORG Developmental I-ORG Biology I-ORG of I-ORG Hunan I-ORG Province I-ORG No. O 20134486 O This O research O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O Grant O No. O 62004144 B-AWARD 61904127 B-AWARD and O 62274122 B-AWARD and O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Advanced I-ORG Welding I-ORG and I-ORG Joining I-ORG in I-ORG the I-ORG Harbin I-ORG Institute I-ORG of I-ORG Technology I-ORG Grant O No. O AWJ-23M09 B-AWARD Additional O thanks O are O also O due O to O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No. O 20212VA100 B-AWARD 2022IVA122 B-AWARD This O study O was O supported O by O the O Thailand B-ORG Research I-ORG Fund I-ORG Grant O number I-AWARD MRG5980002 O Invitation B-ORG Research I-ORG 2018 O Faculty O of O Medicine O IN61210 O and O Research B-ORG Fund I-ORG for I-ORG Supporting I-ORG Lecturer I-ORG to I-ORG Admit I-ORG High I-ORG Potential I-ORG Student I-ORG to I-ORG Study I-ORG and I-ORG Research I-ORG on I-ORG His I-ORG Expert I-ORG Program I-ORG Year I-ORG 2015 I-ORG 581H223 O Graduate O Studies O Khon O Kaen O University O to O KF. O S.S.S O has O received O funding O from O the B-ORG European I-ORG Union’s I-ORG Horizon I-ORG 2020 I-ORG research I-ORG and I-ORG innovation I-ORG programme I-ORG under I-ORG the I-ORG Marie I-ORG Skłodowska-Curie I-ORG grant O agreement O no O 801076 B-AWARD through O the O SSPH O Global O PhD O Fellowship O Programme O in O Public O Health O Sciences O GlobalP3HS O of O the O Swiss O School O of O Public O Health O and O from O the B-ORG Joint I-ORG South I-ORG Africa-Swiss I-ORG Chair I-ORG in I-ORG Global I-ORG Environmental I-ORG Health I-ORG funded I-ORG by I-ORG the I-ORG National I-ORG Research I-ORG Foundation I-ORG South O Africa O grant O number O 94883 B-AWARD O.C O has O been O funded O by O the B-ORG Swiss I-ORG Government I-ORG Excellence I-ORG Scholarship I-ORG ESKAS O ID: O 2020 B-AWARD 0742 O The O National O Research O Foundation O South O Africa O Grant O number O 94883 O This O research O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20190957 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Number O 21978121 B-AWARD the O National O Natural O Science O Foundation O of O China O Grant O Number O 31472127 B-AWARD the O Collaborative B-ORG Innovation I-ORG Project I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG Grant O Number O CAAS-XTCX2016011-04-5 B-AWARD and O the O National B-ORG Chicken I-ORG Industry I-ORG Technology I-ORG System I-ORG of I-ORG China I-ORG Grant O Number O CARS-41 B-AWARD Thanks O to O Editage O for O helping O us O to O polish O the O language O of O the O article O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2016YFB0501403 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 41271399 B-AWARD and O the O China B-ORG Special I-ORG Fund I-ORG for I-ORG Surveying I-ORG Mapping I-ORG and I-ORG Geoinformation I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG Grant O No.201512015 O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81774028 B-AWARD and O 81873146 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017A030310542 O and O the O Traditional B-ORG Chinese I-ORG Medicine I-ORG Bureau I-ORG of I-ORG Guangdong I-ORG Province I-ORG 20161075 O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFB2101504 O the O Shanxi B-ORG Provincial I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG 201803D121081 O and O 201903D121147 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanxi I-ORG Province I-ORG of O China O 201901D111150 O the O Shanxi O Provincial O Graduate O Innovation O Project O 2019SY445 O the O Graduate O Science O and O Technology O Project O at O North O University O of O China O 20191638 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81500921 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O number O 2016YFC0800700 B-AWARD the O Shanghai B-ORG Key I-ORG Laboratory I-ORG of I-ORG Forensic I-ORG Medicine I-ORG grant O number O 17DZ2273200 B-AWARD the O Shanghai B-ORG Forensic I-ORG Service I-ORG Platform I-ORG grant O number O 16DZ290900 B-AWARD This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0901400 O the O Modern B-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG CARS-49 O and O the O Dalian B-ORG Youth I-ORG Science I-ORG and I-ORG Technology I-ORG Star I-ORG Project I-ORG Support I-ORG Program I-ORG 2016RQ065 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O ImageJ2 O was O funded O from O 2010 O through O 2012 O by O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG NIGMS O through O the O American O Recovery O and O Reinvestment O Act O of O 2009 O NIH O Research O and O Research O Infrastructure O “Grand O Opportunities” O Grant O “Hardening” O of O Biomedical O Informatics/Computing O Software O for O Robustness O and O Dissemination O Ref O RC2 B-AWARD GM092519-01 O as O well O as O a O Wellcome B-ORG Trust I-ORG Strategic O Award O Ref O 095931 B-AWARD SCIFIO O was O funded O by O the O National B-ORG Science I-ORG Foundation O award O number O 1148362 B-AWARD ImageJ2 O projects O were O also O funded O by O internal O funding O from O the O Laboratory O for O Optical O and O Computational O Instrumentation O and O the O Morgridge O Institute O for O Research O This O work O was O supported O by O the O Economic B-ORG and I-ORG Social I-ORG Research I-ORG Council I-ORG ES/T008679/1 O the O Medical B-ORG Research I-ORG Council I-ORG MC_UU_00022/1 O MC_UU_00022/2 B-AWARD MC_UU_00022/3 B-AWARD and O the O Chief B-ORG Scientist I-ORG Office I-ORG SPHSU16 O SPHSU17 B-AWARD SPHSU18 B-AWARD EL O is O also O supported O by O MRC B-ORG Skills I-ORG Development I-ORG Fellowship I-ORG Award I-ORG MR/S015078/1 O This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81672786 O 81872306 I-AWARD 81802692 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M640867 O 2019T120774 O and O Guangdong B-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG 2017B030314026 O The O study O was O funded O by O The O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG 2017YFD0309006 O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2013CB127700 O Modern B-ORG Agricultural I-ORG Industry I-ORG System I-ORG of I-ORG Wheat I-ORG Industry I-ORG in I-ORG Hebei I-ORG Province I-ORG HBCT2018010204 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG C2017204115 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O Wellcome B-ORG Trust I-ORG Centre O for O Neuroimaging O is O supported O by O core O funding O from O the O Wellcome O Trust O 091593/Z/10/Z B-AWARD SM O was O supported O by O the O Deutsche B-ORG Forschungsgemeinschaft I-ORG DFG O MO B-AWARD 2397/1-1 O The O research O leading O to O these O results O has O received O funding O from O the O European B-ORG Research I-ORG Council I-ORG under O the O European O Union's O Seventh O Framework O Programme O FP7/2007-2013)/ERC O grant O agreement O n°616905 O Open O access O was O supported O by O the O Wellcome O Trust O XL O was O partially O supported O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 19XNLG14 O and O the O Research O Funds O of O Renmin O University O of O China O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 11571364 O WH O was O partially O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG Grant O DMS-1818769 O This O work O has O been O supported O by O National B-ORG Standardization I-ORG Project I-ORG of I-ORG Chinese I-ORG Medicine I-ORG ZYBZH-C-AH-01 O and O Hong B-ORG Kong I-ORG Macao I-ORG I-ORG Taiwan I-ORG Science I-ORG and I-ORG Technology I-ORG Cooperation I-ORG Project I-ORG 2015DFM30030 O and O The O Fundamental O Research O Funds O for O the O Central B-ORG Public I-ORG Welfare I-ORG Research I-ORG Institutes I-ORG ZZ10-007 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O project O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31560133 O 41501028 B-AWARD the O International B-ORG Crane I-ORG Foundation I-ORG 11001903 O and O the O Key B-ORG Laboratory I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG Nanchang I-ORG University I-ORG 13006457 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81400199 B-AWARD and O No. O 81600217 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20160346 O and O Suzhou B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG China I-ORG No. O SYS201414 B-AWARD This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31571268 O 31871242 O Huazhong B-ORG Agricultural I-ORG University I-ORG Scientific I-ORG I-ORG Technological I-ORG Self-innovation I-ORG Foundation I-ORG Program O No. O 2014RC020 B-AWARD and O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Cotton I-ORG Biology I-ORG Open I-ORG Fund I-ORG CB2017B01 O Each O of O the O funding O bodies O granted O the O funds O based O on O a O research O proposal O They O had O no O influence O over O the O experimental O design O data O analysis O or O interpretation O or O writing O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 61804130 B-AWARD 11832016 I-AWARD 11835008 I-AWARD 51775471 I-AWARD and I-AWARD 51872250 O the O Provincial O Natural O Science O Foundation O of O Hunan O Grant O Nos O 2018JJ3513 O 2018JJ4037 O and O 2018JJ2080 O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2017YFF0105000 B-AWARD the O Program O for O Changjiang O Scholars O and O Innovative O Research O Team O in O University O No. O IRT-14R48 B-AWARD the O Foundation O of O Innovation O Center O of O Radiation O Application O No. O KFZC2018040201 B-AWARD the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Intense I-ORG Pulsed I-ORG Radiation I-ORG Simulation I-ORG and I-ORG Effect I-ORG Northwest O Institute O of O Nuclear O Technology O Nos O SKLIPR1606 B-AWARD and I-AWARD SKLIPR1814 O and O the O Hunan B-ORG Provincial I-ORG Innovation I-ORG Foundation I-ORG for I-ORG Postgraduate I-ORG No. O CX2018B373 B-AWARD The O APC O was O funded O by O the O National O Natural O Science O Foundation O of O China O Grant O No. O 61804130 O The O current O study O was O supported O by O grants O from O Suzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG SYS201345 O Bureau B-ORG of I-ORG Public I-ORG Health I-ORG of I-ORG Jiangsu I-ORG Province I-ORG H201413 O pre-research B-ORG project I-ORG from I-ORG the I-ORG second I-ORG affiliated I-ORG hospital I-ORG of I-ORG Soochow I-ORG university I-ORG SDFEYGJ1609 O and O the B-ORG second I-ORG affiliated I-ORG hospital I-ORG of I-ORG Soochow I-ORG university I-ORG clinical I-ORG discipline I-ORG group I-ORG project I-ORG funding I-ORG XKQ O 2015008 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O T.Y O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Project O http://www.nsfc.gov.cn O Grant O No. O 31771179 B-AWARD Shanghai B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG http://stcsm.sh.gov.cn O Grant O No. O 2018SHZDZX05 B-AWARD and O Strategic O Priority O Research O Program O of O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG http://www.cas.cn O Grant O No. O XDB32070100 B-AWARD The O funders O had O no O roles O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O China B-ORG Scholarship I-ORG Council I-ORG CSC O to O PL O [2015]3022 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O to O WW O 31272686 O Project O Funded O by O the O Priority O Academic O Program O Development O of O Jiangsu O Higher O Education O Institutions O to O WW, O Ministry B-ORG of I-ORG Education I-ORG Culture I-ORG Sports I-ORG Science I-ORG and I-ORG Technology I-ORG MEXT O to O MM O 24117002 O Japan B-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG JSPS O to O MM O 21249030 O and O Japan O Society O for O the O Promotion O of O Science O JSPS O to O MM O 24390107 O This O research O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 22002104 B-AWARD 22202145 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG LQ20E030007 O LTY22E030001 B-AWARD the O Taizhou B-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG No. O 2002gy08 B-AWARD 21gya28 B-AWARD the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Projects I-ORG of I-ORG Zhejiang I-ORG Province I-ORG Grant O No. O 2020C04004 B-AWARD 2021C03007 B-AWARD the O Project B-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Leading I-ORG Talents I-ORG of I-ORG Zhejiang I-ORG Provincial I-ORG High-level I-ORG Talents I-ORG Special I-ORG Support I-ORG Plan I-ORG Grant O No. O 2021R52028 B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81871745 O 31800840 B-AWARD 81625015 B-AWARD and O 31529002 B-AWARD the B-ORG State I-ORG Key I-ORG Development I-ORG Program I-ORG for I-ORG Basic I-ORG Research I-ORG of I-ORG China I-ORG 2015CB553602 O and O the B-ORG Program I-ORG for I-ORG Changjiang I-ORG Scholars I-ORG and I-ORG Innovative I-ORG Research I-ORG Team I-ORG in I-ORG University I-ORG IRT_16R37 O This O research O was O funded O by O National B-ORG Science I-ORG Foundation O CHE-1648973 B-AWARD Foundational B-ORG Questions I-ORG Institute O FQXi-RFP-1622 B-AWARD Air B-ORG Force I-ORG Office I-ORG of I-ORG Scientific I-ORG Research O A9550-15-1-0038 B-AWARD This O work O was O supported O by O EU B-ORG under I-ORG “INFINITE” I-ORG HORIZON-CL5-2021-D5-01-06 O project O by O the O Spanish B-ORG MICIN O under O PID2022-141373NB-I00 B-AWARD project O and O by O the O Government B-ORG of I-ORG the I-ORG Basque I-ORG Country I-ORG under O PUE_2021_1_0009 B-AWARD and O Elkartek B-ORG MINERVA O ZE-KONP O AND O COMPONENS O projects O under O the O scheme O of O “Ayuda O a O Grupos O Consolidados”(ref O IT1670-22 B-AWARD This O research O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81501223 O the B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG of I-ORG Outstanding I-ORG Young I-ORG Scientist I-ORG BS2014YY013 O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 I-ORG Program I-ORG 2012CB944700 O the B-ORG State I-ORG Key I-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81430029 O and O Science B-ORG research I-ORG foundation I-ORG item I-ORG of I-ORG no-earnings I-ORG health I-ORG vocation I-ORG 201402004 O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFA0301300 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC)(61275201 O 61372037 B-AWARD Beijing B-ORG Excellent I-ORG Ph.D I-ORG Thesis I-ORG Guidance I-ORG Foundation I-ORG 20131001301 O BUPT B-ORG Excellent I-ORG Ph.D I-ORG Students I-ORG Foundation I-ORG CX2017401 O This O study O was O supported O by O the O project B-ORG Leading I-ORG Talents I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG in I-ORG Jiangsu I-ORG Province O SLJ0207 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O 81774334 O Jiangsu B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG Social I-ORG Development I-ORG Fund O BE2017774 O This O work O was O supported O by O Qingyuan B-ORG Industrial I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Special I-ORG Funds I-ORG No.2017A021 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG No.2018A030307065 O Qingyuan B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG Funding I-ORG in I-ORG Disease I-ORG Prevention I-ORG and I-ORG Treatment I-ORG No.2019A035 O This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81401297 B-AWARD the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG No. O 2012CB518905 B-AWARD and O Natural B-ORG Science I-ORG Foundation I-ORG Research I-ORG Project O of O Shaanxi O province O in O China O No. O 2015JQ8295 B-AWARD This O work O was O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFB1002503 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31470974 O 31230029 B-AWARD National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 863 O Program O No. O 2012AA011602 O The O funding O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O National B-ORG Institutes I-ORG of I-ORG Health I-ORG grant O PO1 B-AWARD HL040962 I-AWARD and O a O National B-ORG Science I-ORG Foundation I-ORG CAREER O Award O 1351748 B-AWARD and O by O National B-ORG Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute I-ORG of O the O National O Institutes O of O Health O under O Award O Numbers O P01HL040962 B-AWARD This O work O is O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81802806 O 81472621 B-AWARD and O 81402329 B-AWARD National B-ORG Program I-ORG on I-ORG Key I-ORG Research I-ORG Project I-ORG of I-ORG China I-ORG 2016YFC0902701 O Precision O Medicine O Medical B-ORG and I-ORG Engineering I-ORG Crossover I-ORG Fund I-ORG of I-ORG SJTU I-ORG YG2016QN71 O YG2017MS67 B-AWARD the O University B-ORG of I-ORG Sydney I-ORG I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG Joint I-ORG Research I-ORG Alliance I-ORG SJTU-USYD O Translational O Medicine O Fund-Systems O Biomedicine O AF6260003 B-AWARD and O funding O from O Key B-ORG Laboratory I-ORG of I-ORG Systems I-ORG Biomedicine I-ORG Ministry O of O Education O KLSB2017QN-03 O The O funding O bodies O didn’t O involve O in O the O design O of O the O study O collection O analysis O interpretation O of O data O or O writing O the O manuscript O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 81672069 B-AWARD 81570122 O 81770205 O the O Shanghai O Municipal O International O Cooperation O Grant O grant O number O 16410711900 O the O Major B-ORG National I-ORG Projects I-ORG for I-ORG Infectious I-ORG Diseases I-ORG grant O numbers O 2017ZX10202202 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG grant O number O 2016YFC0902800 B-AWARD Shanghai O Municipal O Education O Commission-Gaofeng O Clinical O Medicine O Grant O Support O grant O number O 20161303 O the O Program O for O Professor O of O Special O Appointment O Eastern O Scholar O at O Shanghai O Institutions O of O Higher O Learning O grant O number O QD2015005 O and O the O Shanghai O Health O and O Family O Planning O Commission O Grant O grant O number O 201640089 O These O funding O bodies O played O no O role O in O any O of O the O following O study O design O data O collection O analysis O and O interpretation O manuscript O writing O This O study O was O funded O by O the O Shandong B-ORG Agricultural I-ORG Seeds I-ORG Engineering I-ORG Project I-ORG Collection O Protection O and O Precision O Identification O of O Forest O Tree O Germplasm O Resources O 2019LZGC01802 B-AWARD the O Shandong B-ORG Provincial I-ORG Agricultural I-ORG Elite I-ORG Varieties I-ORG Project I-ORG 2016LZGC038 O and O the O Forestry B-ORG Science I-ORG I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG Shandong I-ORG Province I-ORG LYCX01-2018-03 O China O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O CEAL-AL/2015-27 O Banco B-ORG Santander-UAM I-ORG grant I-ORG Spain O the O PROMETEO/2017/189 B-AWARD grant O from O the O Generalitat B-ORG Valenciana I-ORG Spain O and O the O Juan B-ORG de I-ORG la I-ORG Cierva I-ORG Fellowship I-ORG Program I-ORG JCI-2012-14172 O MINECO O Spain O to O María O Reguera O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O study O was O supported O by O Opening B-ORG Foundation I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Kidney I-ORG Diseases I-ORG KF-01-115 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81773502 O 81703285 I-AWARD 81703308 O Beijing B-ORG Nova I-ORG Program I-ORG Z181100006218085 O Medical B-ORG Big I-ORG Data I-ORG Fund I-ORG of I-ORG Chinese I-ORG PLA I-ORG General I-ORG Hospital I-ORG 2018MBD-029 O Opening B-ORG Foundation I-ORG of I-ORG National I-ORG Clinical I-ORG Research I-ORG Center I-ORG of I-ORG Geriatrics I-ORG NCRCG-PLAGH-2017017 O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31771875 O 31871702 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0100806 O 2017YFD0102001 B-AWARD 2017YFD0101201 B-AWARD the O National B-ORG Transgenic I-ORG Major I-ORG Program I-ORG of I-ORG China I-ORG 2018ZX0801006B O 2018ZX0800922B B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG China I-ORG 06500060 O the O “Ten O Thousand O Plan”-National O High O Level O Talents O Special O Support O Plan O For O Xiangyuan O Wan O and O the O Beijing B-ORG Talents I-ORG Foundation I-ORG Team O project I-AWARD hosted I-AWARD by I-AWARD Xiangyuan I-AWARD Wan O This O research O was O funded O by O the O Junta B-ORG de I-ORG Andalucía I-ORG CTS O 164 O CV20-77708 B-AWARD Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III I-ORG PI19/01058 O PI20/01447 B-AWARD and O by O the O “Fundación O Andaluza I-ORG de I-ORG Farmacia I-ORG Hospitalaria” O 3095/2020 O This O work O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81673268 O 81903411 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2018A030313849 O and O the O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG 2019A1515011506 O The O funding O body O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O grants O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 1473233 B-AWARD the B-ORG Science I-ORG Foundation I-ORG from I-ORG the I-ORG Sci-Tech I-ORG Office I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG No. O 2016A020215083 B-AWARD and O the B-ORG Science I-ORG Foundation I-ORG from I-ORG the I-ORG Sci-Tech I-ORG Office I-ORG of I-ORG Foshan I-ORG City I-ORG China I-ORG No. O 2015AB00294 B-AWARD This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.41804112 O Scientific B-ORG Research I-ORG Foundation I-ORG of I-ORG Chongqing I-ORG University I-ORG of I-ORG Technology I-ORG No.2019ZD07 O and O Chongqing B-ORG Research I-ORG Program I-ORG of I-ORG Basic I-ORG Research I-ORG and I-ORG Frontier I-ORG Technology I-ORG No.cstc2018jcyjAX0287 O to O CS. O Additionally O JD O Urban O computing O business O unit O provided O support O for O this O study O in O the O form O of O salary O for O WL. O The O specific O role O of O this O author O is O articulated O in O the O ‘author O contributions’ O section O This O study O was O supported O by O projects O of O International B-ORG Cooperation I-ORG and I-ORG Exchanges I-ORG NSFC I-ORG 51561145014 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2015M571316 O and O the O National B-ORG Key I-ORG Laboratory I-ORG project I-ORG of I-ORG Microbial I-ORG Metabolism I-ORG MMLKF16-04 O This O work O was O supported O by O grants O from O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China O Nature B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG province I-ORG and O China B-ORG postdoctoral I-ORG science I-ORG foundation I-ORG to O J.Y O No. O 81502881 B-AWARD 2017JJ3428 B-AWARD and O 2015M582351 B-AWARD Dr. O Yan O is O a O postdoctoral O fellow O at O Central O South O University O No. O 149946 O supported O by O the O Postdoctoral O International O Exchange O Plan O in O China O The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O present O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG nos O 81972329 B-AWARD 81201947 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG China I-ORG ZR2009CM014 O the O Excellent B-ORG Young I-ORG Scientist I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG China I-ORG no. O 2006BSB14001 B-AWARD the O Qingdao B-ORG Minsheng I-ORG Science I-ORG and I-ORG Technology I-ORG project I-ORG no. O 17-3-3-38-nsh B-AWARD and O the O Excellent B-ORG Young I-ORG Scientist I-ORG Foundation I-ORG of I-ORG the I-ORG Affiliated I-ORG Hospital I-ORG of I-ORG Qingdao I-ORG University I-ORG no. O 3055 B-AWARD There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 82003533 B-AWARD the O Chinese B-ORG Nutrition I-ORG Society-ZD I-ORG Tizhi I-ORG and I-ORG Health I-ORG Fund I-ORG No. O CNS-ZD2020-82 B-AWARD the O Swedish B-ORG Research I-ORG Council I-ORG Nos O 2017-00981 B-AWARD and O 2021-01647 B-AWARD the O Swedish B-ORG Council I-ORG for I-ORG Health I-ORG Working I-ORG Life I-ORG and I-ORG Welfare I-ORG 2021-01826 O and O Karolinska B-ORG Institutet I-ORG Research I-ORG Foundation I-ORG 2020-01660 O As O an O important O basis O for O planning O outcomes O this O manuscript O was O funded O by O the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0505702 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41771181 O and O Open B-ORG Fund I-ORG Project I-ORG of I-ORG New I-ORG Urbanization I-ORG Research I-ORG Institute I-ORG of I-ORG Tsinghua I-ORG University I-ORG TUCSU—K—17015—01 O This O work O was O supported O by O the O Young B-ORG Taishan I-ORG Scholars I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG tsqn201812112 O Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG ZR2020QB024 O Scientific B-ORG Research I-ORG and I-ORG Innovation I-ORG Fund I-ORG Project I-ORG of I-ORG Shandong I-ORG Energy I-ORG Institute I-ORG SEII202116 O Special B-ORG Fund I-ORG Project I-ORG of I-ORG Shandong I-ORG Energy I-ORG Institute I-ORG SEIS202101 O and O Shandong B-ORG Key I-ORG R&D I-ORG Plan I-ORG Major O Scientific O and O Technological O Innovation O Project O 2022CXGC020604 O are O gratefully O acknowledged O This O work O was O financially O supported O by O Natural B-ORG Science I-ORG Research I-ORG Fund I-ORG for I-ORG Colleges I-ORG and I-ORG Universities I-ORG in I-ORG Anhui I-ORG Province I-ORG Grant O No. O KJ2018A0172 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81760638 B-AWARD the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Xinjiang I-ORG Province I-ORG Grant O No. O 2017D01C200 B-AWARD Special B-ORG Science I-ORG and I-ORG Frontier I-ORG Technology I-ORG Research I-ORG Project I-ORG of I-ORG Chongqing I-ORG cstc2016jcyjA1580 O and O Error B-ORG Hyperlink I-ORG reference I-ORG not I-ORG valid I-ORG Grant O No. O HAB201717 B-AWARD This O research O was O funded O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2022YFB4202102 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 42071014 O the O Key B-ORG R I-ORG I-ORG D I-ORG Program I-ORG of I-ORG Ningxia I-ORG Hui I-ORG Autonomous I-ORG Region I-ORG 2019BFG02010 O 2022BEG02003 B-AWARD and O the O Excellent B-ORG Member I-ORG of I-ORG Youth I-ORG Innovation I-ORG Promotion I-ORG Association I-ORG CAS I-ORG No. O Y202085 O W.Z O is O supported O by O the O Haihe B-ORG Laboratory I-ORG of I-ORG Cell I-ORG Ecosystem I-ORG Innovation I-ORG Fund I-ORG under O award O number O 22HHXBSS00030 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O award O number O 82130006 B-AWARD Y.H O is O supported O by O the O Natural O Science O Foundation O of O China O under O award O number O 82170202 B-AWARD This O review O is O supported O by O the O Fundamental B-ORG Research I-ORG Fund I-ORG for I-ORG Graduate I-ORG of I-ORG Central I-ORG South I-ORG University I-ORG under O award O number O 506021717 B-AWARD This O research O was O supported O by O the O key B-ORG research I-ORG and I-ORG development I-ORG projects I-ORG in I-ORG Anhui I-ORG province I-ORG 2022a05020069 O the O educational B-ORG commission I-ORG of I-ORG Anhui I-ORG province I-ORG of I-ORG China I-ORG 2022AH040137 O 2022AH050990 B-AWARD key B-ORG laboratory I-ORG of I-ORG intelligent I-ORG textile I-ORG and I-ORG flexible I-ORG interconnection I-ORG of I-ORG Zhejiang I-ORG province I-ORG ZD04 O open B-ORG project I-ORG program I-ORG of I-ORG Anhui I-ORG engineering I-ORG and I-ORG technology I-ORG research I-ORG center I-ORG of I-ORG textile I-ORG 2021AETKL09 O the O scientific B-ORG research I-ORG project I-ORG of I-ORG Anhui I-ORG polytechnic I-ORG university I-ORG Xjky2020039 O Xjky2022079 B-AWARD 2022YQQ057 B-AWARD FFBK202362 B-AWARD KH10002945 B-AWARD JX22022115 B-AWARD KP1Z202132 B-AWARD KP40000117 B-AWARD Y412022007 B-AWARD and O S022020044 B-AWARD project O supported O by O the O scientific B-ORG research I-ORG activity I-ORG fund I-ORG for I-ORG post-doctoral I-ORG researchers I-ORG of I-ORG Anhui I-ORG province I-ORG 2022B590 O This O study O was O partially O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFD0500400 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31772742 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG No.2015A03031103 O This O work O was O supported O by O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG CAPES O O Brazil O grant O 88881.128982/2016-01 B-AWARD Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG grant O number O BB/D010055/1 B-AWARD and O the O Engineering B-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG EPSRC O Grant O Nos O GR/S75918/01 B-AWARD and O EP/K023349/1 B-AWARD This O research O was O funded O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 32102006 B-AWARD Zhejiang B-ORG province I-ORG key I-ORG research I-ORG and I-ORG development I-ORG program I-ORG No. O 2023C04007 O Quzhou B-ORG City I-ORG Scientific I-ORG and I-ORG Technological I-ORG Project I-ORG No. O 2022K25 O Zhejiang B-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG Project I-ORG No. O Y202147379 O and O Open O Fund O of O Zhejiang B-ORG Sci-Tech I-ORG University I-ORG Shaoxing I-ORG Academy I-ORG of I-ORG Biomedicine I-ORG Co I-ORG Ltd I-ORG No. O SXAB202008 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 31201904 O Special B-ORG Fund I-ORG for I-ORG Agro-scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG 201303046 O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2011AA10A213 O Central B-ORG Finance I-ORG Funds I-ORG for I-ORG Agro-technical I-ORG Popularization I-ORG TG(14)067 O and O the O Independent B-ORG Innovation I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG CX O 14)5045 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81573090 O 81172595 B-AWARD Postdoctor B-ORG Foundation I-ORG of I-ORG China I-ORG 20100480905 O and O Postdoctor B-ORG Special I-ORG Foundation I-ORG of I-ORG China I-ORG 201104440 O This O research O was O funded O by O the O European B-ORG Research I-ORG Council I-ORG ERC O under O the O EU O Horizon O 2020 O research O and O innovation O programme O SCENT-ERC-2014-STG-639123 O 2015–2022 O and O Grant O Agreement O No. O 101069405-ENSURE-ERC-2022-POC1 B-AWARD and O by O national O funds O from O FCT-Fundação B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG a I-ORG Tecnologia O I.P O in O the O scope O of O the O project O UIDP/04378/2020 B-AWARD and O UIDB/04378/2020 B-AWARD of O the O Research O Unit O on O Applied O Molecular O Bio-sciences O UCIBIO O and O the O project O LA/P/0140/2020 B-AWARD of O the O Associate B-ORG Laboratory I-ORG Institute I-ORG for I-ORG Health I-ORG and I-ORG Bioeconomy I-ORG and I-ORG i4HB O The O authors O thank O FCT/MCTES B-ORG for O the O PhD O grants O SFRH/BD/128687/2017 B-AWARD and O SFRH/BD/14131/2019 B-AWARD Funded O by O National B-ORG Health I-ORG Research I-ORG Institutes I-ORG of I-ORG Taiwan O NHRI-EX98-9838PI B-AWARD Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Taiwan.http://dx.doi.org/10.13039/501100004663 O MOST B-AWARD 104-2314-B-039-016 I-AWARD I-AWARD MOST I-AWARD 105-2314-B-039 I-AWARD 025-MY3 I-AWARD I-AWARD MOST I-AWARD 105-2314-B-039-021-MY3 I-AWARD I-AWARD MOST I-AWARD 108-2314-B-039-031-MY2 I-AWARD I-AWARD MOST I-AWARD 108-2314-B-039-035-MY3 I-AWARD China B-ORG Medical I-ORG University I-ORG Hospital O DMR-107-088 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O No. O 61701284 B-AWARD 61871370 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG of I-ORG China I-ORG under O Grant O No. O ZR2022MF226 B-AWARD the O Talented B-ORG Young I-ORG Teachers I-ORG Training I-ORG Program I-ORG of I-ORG Shandong I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG under O Grant O No. O BJ20221101 B-AWARD the O Innovative B-ORG Research I-ORG Foundation I-ORG of I-ORG Qingdao I-ORG under O Grant O No. O 19-6-2-1-cg B-AWARD the O Elite B-ORG Plan I-ORG Project I-ORG of I-ORG Shandong I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG under O Grant O No. O skr21-3-B-048 B-AWARD the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG under O Grant O No. O 2019YFE0120700 B-AWARD 2019YFB1803101 B-AWARD the O Hundred B-ORG Talent I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG under O Grant O No. O E06BRA1001 B-AWARD the O Sci B-ORG I-ORG Tech I-ORG Development I-ORG Fund I-ORG of I-ORG Shandong I-ORG Province I-ORG of I-ORG China I-ORG under O Grant O No. O ZR202102230289 B-AWARD ZR202102250695 B-AWARD and O ZR2019LZH001 B-AWARD the O Humanities B-ORG and I-ORG Social I-ORG Science I-ORG Research I-ORG Project I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG under O Grant O No. O 18YJAZH017 B-AWARD the O Taishan B-ORG Scholar I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG under O Grant O No. O ts20190936 B-AWARD the O Shandong B-ORG Chongqing I-ORG Science I-ORG and I-ORG technology I-ORG cooperation I-ORG project I-ORG under O Grant O No. O cstc2020jscx-lyjsAX0008 B-AWARD the O Sci B-ORG I-ORG Tech I-ORG Development I-ORG Fund I-ORG of I-ORG Qingdao I-ORG under O Grant O No. O 21-1-5-zlyj-1-zc B-AWARD the O SDUST B-ORG Research I-ORG Fund I-ORG under O Grant O No. O 2015TDJH102 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Support I-ORG Plan I-ORG of I-ORG Youth I-ORG Innovation I-ORG Team I-ORG of I-ORG Shandong I-ORG higher I-ORG School I-ORG under O Grant O No. O 2019KJN024 B-AWARD This O research O has O been O funded O by O Medical B-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG A2017258 O Science B-ORG Research I-ORG Initiative I-ORG of I-ORG Southern I-ORG Medical I-ORG University I-ORG C1034402 O and O Joint B-ORG TDR/WPR I-ORG Small I-ORG Grants I-ORG Scheme I-ORG for I-ORG Implementation I-ORG Research I-ORG in I-ORG Infectious I-ORG Diseases I-ORG of I-ORG Poverty I-ORG HQTDR1611221 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O has O been O funded O by O BBMRI-NL B-ORG Complementary O project O CP2013-69 B-AWARD ZonMW B-ORG Priority I-ORG Medicine I-ORG Elderly I-ORG grant O no. O 113102006 B-AWARD to O LMtH O RCS O LMtH O and O JWJB O received O support O from O the O Innovative O Medicines O Initiative O 2 O Joint O Undertaking O under O grant O agreement O no. O 115881 B-AWARD RHAPSODY O This O Joint O Undertaking O receives O support O from O the O European O Union’s O Horizon O 2020 O research O and O innovation O programme O and O European O Federation O of O Pharmaceutical O Industries O and O Associations O EFPIA O and O is O supported O by O the O Swiss O State O Secretariat O for O Education‚ O Research O and O Innovation O SERI O under O contract O no. O 16.0097-2 B-AWARD The O work O leading O to O this O publication O has O received O support O from O the O Innovative O Medicines O Initiative O Joint O Undertaking O under O grant O agreement O no. O 115317 O DIRECT O resources O of O which O are O composed O of O financial O contribution O from O the O European O Union's O Seventh O Framework O Programme O FP7/2007-2013 O and O EFPIA O companies’ O in O kind O contribution O Information O on O the O project O can O be O found O athttps://www.direct-diabetes.org O RB O and O AJvZ O were O supported O by O funding O of O the O European O Foundation O for O the O Study O of O Diabetes O The O opinions O expressed O and O arguments O employed O herein O do O not O necessarily O reflect O the O official O views O of O these O funding O bodies O JAdK O was O supported O by O the O Medical O Genomics O research O theme O at O Leiden O University O Medical O Centre O This O work O was O supported O by O grants O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG 2018YFD0100500 O and I-AWARD 2016YFD0101007 O the O Southwest O University’s O Training O Program O of O Innovation O and O Entrepreneurship O for O Undergraduates O 5240101327 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31871653 O the O 111 B-ORG project I-ORG B12006 O the O Natural O Science O Foundation O of O Chongqing O China O cstc2018jcyjA1219 O and O the O Chongqing O Agricultural O Development O Fund O NKY-2019AB008-2 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81671060 B-AWARD and O 81771160 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province O China O No.2019CFB106 O Cultivation B-ORG fund I-ORG from I-ORG Zhongnan I-ORG Hospital I-ORG Wuhan I-ORG University I-ORG znpy2018092 O and O Young B-ORG teacher I-ORG funding I-ORG program I-ORG from I-ORG Wuhan I-ORG University O 2042018kf0197 O O We O acknowledge O the O funders O of O this O study O the O National B-ORG Institute I-ORG of I-ORG Diabetes I-ORG and I-ORG Digestive I-ORG and I-ORG Kidney I-ORG Diseases I-ORG National I-ORG Institutes I-ORG of I-ORG Health I-ORG K23DK095981;http://www.niddk.nih.gov O MJO O the O Agency B-ORG for I-ORG Healthcare I-ORG Research I-ORG and I-ORG Quality I-ORG P01HS21141;http://www.ahrq.gov O and O the O Chicago B-ORG Center I-ORG for I-ORG Diabetes I-ORG Translation I-ORG Research I-ORG P30DK092949;http://chicagodiabetesresearch.org/pilot-and-feasibility-grants O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O We O thank O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 11704263 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG Grant O No. O F2018501063 B-AWARD Hebei B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG Research I-ORG Funds I-ORG Grant O No. O 18273902D B-AWARD for O financial O support O This O work O was O performed O in O part O at O the O Melbourne O Centre O for O Nanofabrication O MCN O in O the O Victorian O Node O of O the O Australian O National O Fabrication O Facility O ANFF O This O publication O was O supported O by O the O European O Structural O and O Investment O Funds O Operational O Programme O Research O Development O and O Education O under O the O project O The B-ORG Development I-ORG of I-ORG Capacity I-ORG for I-ORG Research I-ORG and I-ORG Development I-ORG of I-ORG TBU I-ORG in I-ORG Zlín O reg O no. O CZ.02.2.69/0.0/0.0/16_028/0006243 B-AWARD and O by O the O Ministry B-ORG of I-ORG Education I-ORG Youth I-ORG and I-ORG Sports I-ORG under I-ORG project I-ORG DKRVO I-ORG RP/CPS/2022/007 O In O addition O this O study O was O supported O by O the O Internal B-ORG Grant I-ORG Agency I-ORG of I-ORG Tomas I-ORG Bata I-ORG University I-ORG under O project O No. O IGA/CPS/2022/002 B-AWARD and O IGA/CPS/2023/006 B-AWARD This O study O was O supported O by O the O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG 21YF1440200 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81972000 O 82172348 B-AWARD 81902139 B-AWARD Zhongshan B-ORG Hospital I-ORG 2018ZSLC05 O 2020ZSLC54 B-AWARD 2021ZSQN37 B-AWARD the O Constructing O Project O of O Clinical O Key O Disciplines O in O Shanghai O shslczdzk03302 O and O the O Key O Medical O and O Health O Projects O of O Xiamen O YDZX20193502000002 O The O present O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31101727 O the O International B-ORG Cooperation I-ORG in I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2014HH0034 O the O Program B-ORG for I-ORG Changjiang I-ORG Scholars I-ORG and I-ORG Innovative I-ORG Research I-ORG Team I-ORG in I-ORG University I-ORG IRT13083 O and O the O Development B-ORG Plan I-ORG for I-ORG Sichuan I-ORG Strategically I-ORG New I-ORG Products I-ORG 2015GZX0011 O Tongwei O group O Co O Ltd O partly O provided O support O in O the O form O of O salaries O for O YC, O but O did O not O have O any O additional O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O specific O roles O of O Yuanfang O Cheng O are O articulated O in O the O ‘author O contributions’ O section O This O research O was O supported O and O financed O by O the O Key B-ORG Research I-ORG Project I-ORG of I-ORG Shandong I-ORG Province I-ORG of I-ORG China I-ORG under O Grant O No. O 2017GGX40124 B-AWARD the O Project B-ORG of I-ORG Shandong I-ORG Province I-ORG Higher I-ORG Educational I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG under O Grant O No. O J16LN27 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG University I-ORG of I-ORG Jinan I-ORG under O Grant O No. O XKY1735 B-AWARD This O research O was O funded O by O National B-ORG Taiwan I-ORG University I-ORG Hospital O NTUH B-AWARD 103-M2601 O National B-ORG Defense I-ORG Medical I-ORG College O NDMC B-AWARD grant I-AWARD MAB-104-69 O National B-ORG Science I-ORG Council O 105-2314-B-002-003-MY3 B-AWARD This O work O was O supported O by O the O Natural B-ORG Sciences I-ORG and I-ORG Engineering I-ORG Research I-ORG Council I-ORG of I-ORG Canada I-ORG NSERC O from O J.R.W O RGPIN-2016-05124 O NSERC O from O C.J.W O RGPIN-2017-06683 O and O the O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG CIHR O grant O no. O PJT-321478 B-AWARD This O work O was O supported O by O the O European O Union O Seventh B-ORG Framework I-ORG Programme I-ORG FP7/2007-2013 O and O FP7/2007-2011 O 306090 O United B-ORG States I-ORG Agency I-ORG for I-ORG International I-ORG Development I-ORG USAID O AID-OAA-A-16-00018 O and O Wellcome B-ORG Trust I-ORG Core O Grant O awarded O to O the O KEMRI-Wellcome O Trust O Research O Program O for O EB O 092654 O This O publication O reflects O only O the O authors’ O views O and O funders O are O not O liable O for O any O use O that O may O be O made O of O the O information O contained O herein O This O study O was O supported O by O the O Key B-ORG Laboratory I-ORG of I-ORG Superior I-ORG Forage I-ORG Germplasm I-ORG in I-ORG the I-ORG Qinghai-Tibetan I-ORG plateau I-ORG 2017-ZJ-Y12 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 3177131276 O and O the O earmarked O fund O for O Modern B-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG No. O CARS-34 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the B-ORG Subproject I-ORG of I-ORG the I-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG 2021YFC2701002 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81801461 O 81873836 B-AWARD 81771594 B-AWARD 81671474 B-AWARD 81501267,82101796 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2019A1515012034 O the O Project B-ORG of I-ORG Guangzhou I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG 202201020643 O and O the O Project B-ORG of I-ORG Guangzhou I-ORG Health I-ORG Commission I-ORG 20221A011029 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 41971226 B-AWARD 41871357 B-AWARD the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC1503103 O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDA19030303 O XDA28110502 B-AWARD and O the O Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG 2022NSFSC1096 O This O work O was O supported O by O the O One O Hundred O Person O Project O of O The B-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Projects I-ORG in I-ORG Xinjiang I-ORG No. O 2014AB043 B-AWARD the O Prospective B-ORG Joint I-ORG Research I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BY2016-078-02 O and O Xinjiang B-ORG Science I-ORG and I-ORG Technology I-ORG Assistance I-ORG Program I-ORG 2016E02067 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG Program I-ORG 2016YFC0400208 O Postgraduate B-ORG Research I-ORG I-ORG Practice I-ORG Innovation I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG SJKY19_0521 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2019B67914 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Faculty B-ORG of I-ORG Medicine I-ORG Chiang I-ORG Mai I-ORG University I-ORG Grant O no I-AWARD 071/2560 O to O WD, O Center B-ORG of I-ORG Excellence I-ORG Chiang I-ORG Mai I-ORG University I-ORG to O WD, O and O National B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Agency I-ORG NSTDA O Thailand O Grant O no I-AWARD P-15-50169 O to O NK. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O work O was O supported O by O grants O from O the O National B-ORG Mega-Project I-ORG for I-ORG the I-ORG Prevention I-ORG and I-ORG Control I-ORG of I-ORG Infectious I-ORG Diseases I-ORG No. O 2018ZX10713003 B-AWARD Beijing O Municipal O Natural O Science O Foundation O 7172158 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 11501339 B-AWARD and O the O China B-ORG Scholarship I-ORG Council I-ORG 201706320278 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O 61872190 B-AWARD Grant O 61572263 B-AWARD and O Grant O 61772285 B-AWARD the O Postdoctoral B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O 2015M581794 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG under O Grant O BK20161516 B-AWARD and O the O Postdoctoral O Science O Foundation O of O Jiangsu O Province O under O Grant O 1501023C B-AWARD This O project O has O received O funding O from O the O Hellenic B-ORG Foundation I-ORG for I-ORG Research I-ORG and I-ORG Innovation I-ORG HFRI I-ORG and I-ORG the I-ORG General I-ORG Secretariat I-ORG for I-ORG Research I-ORG and I-ORG Technology I-ORG GSRT O under O grant O agreement O no. O 2040 B-AWARD V.B O and O V.K O Also O this O study O is O co-financed O by O Greece O and O the O European O Union O European O Social O Fund O through O the O operational O programme O ‘Human O Resources O Development O Education O and O Lifelong O Learning’ O in O the O context O of O the O project O ‘Strengthening O Human O Resources O Research O Potential O via O Doctorate O Research’ O MIS-5000432 O implemented O by O the O State B-ORG Scholarships I-ORG Foundation I-ORG ΙΚΥ O M.K O by O the O Hellenic O Foundation O for O Research O and O Innovation O HFRI O and O the O General O Secretariat O for O Research O and O Technology O GSRT O under O the O HFRI O PhD O Fellowship O grant O grant O agreement O no. O 91.0005 B-AWARD N.K O and O the O European B-ORG Union's I-ORG Horizon I-ORG INFRAVEC I-ORG research I-ORG and I-ORG innovation I-ORG programme I-ORG under O grant O agreement O no. O 731060 B-AWARD J.V O Support O is O also O acknowledged O to O the O Argentine B-ORG National I-ORG Scientific I-ORG and I-ORG Technological I-ORG Research I-ORG Council I-ORG CONICET O PIP O 150100390 B-AWARD M.P.J O This O work O was O supported O by O the O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health I-ORG R21MH109360 O co-PIs O Brandon O D.L O Marshall O Philip O A. O Chan O Brandon O D.L O Marshall O is O further O supported O by O the O National B-ORG Institute I-ORG on I-ORG Drug I-ORG Abuse I-ORG DP2DA040236 O Additional O support O was O provided O by O the O Providence/Boston O Center O for O AIDS O Research O funded O by O the O National B-ORG Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases I-ORG P30AI042853 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O an O unconditional O grant O fromMetabolic O Technologies I-ORG Inc I-ORG the I-ORG Medical I-ORG Research I-ORG Council[grant O number O MR/K00414X/1 B-AWARD andArthritis O Research I-ORG UK[grant O number O 19891 B-AWARD DJ O Wilkinson O was O a O post-doctoral O research O fellow O funded O through O the O MRC-ARUK O Centre O for O Musculoskeletal O Ageing O Research O awarded O to O the O Universities O of O Nottingham O and O Birmingham O Metabolic O Technologies O Inc O supplied O the O Ca-HMB O on O a O collaborative O basis O and O undertook O the O HMB O plasma O analyses O but O were O blinded O to O the O sample O identities O A O Philp O is O supported O byBBSRC O New I-ORG Investigator I-ORG Award[grant O number O BB/L023547/1 B-AWARD This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Gansu I-ORG Province I-ORG 21JR7RA607 O and O 21JR7RA613 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 72264002 O the O China B-ORG Medical I-ORG Education I-ORG Association I-ORG Project I-ORG 2022KTZ010 O and O the O Health B-ORG Industry I-ORG Research I-ORG Plan I-ORG Project I-ORG of I-ORG Gansu I-ORG Province I-ORG GSWSKY-2019-50 O This O work O was O supported O by O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG Joel O C. O Creed O Ciências O do O Mar O 1137/2010 B-AWARD Fundação B-ORG Carlos I-ORG Chagas I-ORG Filho I-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG do I-ORG Rio I-ORG de I-ORG Janeiro I-ORG Katia O Cristina O Cruz O Capel O Joel O C. O Creed O and O Carla O Zilberberg O FAPERJ-E-26/010.003031/2014 B-AWARD PensaRio O Joel O C. O Creed O E26/201.286/2014 B-AWARD Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG Joel O C. O Creed O CNPq-305330/2010-1 B-AWARD and O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo I-ORG Marcelo O V. O Kitahara O FAPESP B-AWARD 2014/01332-0 O and O Award O NSF-OA#14-16889 B-AWARD National O Science I-ORG Foundation O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31661143039 O 31421003 B-AWARD and O 31800916 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG Project O 2017A030310553 B-AWARD Science B-ORG Foundation I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG Project O 17YJCZH121 B-AWARD and O German B-ORG Research I-ORG Foundation I-ORG Project O HE I-AWARD 4566/2-1 O This O work O was O supported O by O the O National B-ORG Parasitic I-ORG Resources I-ORG Center I-ORG NPRC-2019-194-30 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 31560179 B-AWARD and I-AWARD 21866020 O and O the O Nanchang B-ORG University I-ORG College I-ORG Students’ I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Training I-ORG Program I-ORG No. O 2018388 B-AWARD and O Nanchang B-ORG University’s I-ORG Scientific I-ORG Research I-ORG Training I-ORG Program I-ORG 20190402197 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Research O reported O in O this O publication O was O supported O by O funds O from O theMucosal O Immunology I-ORG Group(BMGF O OPP1099507 B-AWARD the O Collaboration O for O AIDS O Vaccine O Discovery O Grants O from O theBill O and I-ORG Melinda I-ORG Gates I-ORG Foundation(OPP1040758 O OPP1032144 B-AWARD OPP1032325 B-AWARD OPP1033098 B-AWARD and O from O theNational O Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseasesof O the O National O Institutes O of O Health O under O award O numbers O UM1 B-AWARD AI068618 I-AWARD Laboratory O Center O HIV O Vaccine O Trials O Network O UM1 B-AWARD AI069481 I-AWARD Seattle-Lausanne-Kampala O CTU O U19 B-AWARD AI067854 I-AWARD the O Center O for O HIV/AIDS O Vaccine O Immunology O UM1 B-AWARD AI100645 I-AWARD Duke O Center O for O HIV/AIDS O Vaccine O Immunology O O Immunogen O Discovery O and O P30 B-AWARD AI027767 I-AWARD Birmingham O Center O for O AIDS O Research O Virology O Core O This O work O is O supported O by O the O Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Plan I-ORG 19441903100 O the O Shanghai B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG Program I-ORG 1541196900 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61471125 O This O study O was O supported O by O grants O from O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG grant O number O 2016YFC0800702 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 81571851 B-AWARD and O 81401559 B-AWARD Science B-ORG and I-ORG Technology I-ORG Committee I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG grant O numbers O 17DZ2273200 B-AWARD and O 16DZ2290900 B-AWARD This O project O received O seed O funding O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 81271383 B-AWARD 81471245 B-AWARD the O Shanghai B-ORG Science I-ORG and I-ORG Technique I-ORG Committee I-ORG grant O no.13411951401 O and O the O Shanghai B-ORG Municipal I-ORG Health I-ORG Bureau I-ORG project I-ORG grant O no. O 20114242 B-AWARD The O provider O of O the O financial O support O was O not O involved O in O the O study O design O collection O analysis O and O interpretation O of O the O data O in O the O writing O of O the O manuscript O and O in O the O decision O to O submit O the O manuscript O for O publication O The O current O research O was O financially O supported O by O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG No. O 2013CB127501 B-AWARD the O Special B-ORG Fund I-ORG for I-ORG Agro-scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG China I-ORG No. O 201503114 B-AWARD and O Chinese B-ORG Universities I-ORG Scientific I-ORG Fund I-ORG No. O 2015NX005 B-AWARD This O study O was O supported O by O a O grant O 1081B30 O from O the O MacKay B-ORG Medical I-ORG College O partially O by O a O grant O from O the O MMH-MM-10704 O from O the O MacKay B-ORG Memorial I-ORG Hospital O and O partially O by O grants O MOST O 106-2320-B-715-005-MY3 O and O MOST B-AWARD 109-2320-B-715-004 O from O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Taiwan O Republic O of O China O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81472335 B-AWARD to O W.G O No. O 81572441 B-AWARD to O Z.M.D O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG of I-ORG China I-ORG No.H2013206315 O to O Y.L.G O No. O H2015206196 B-AWARD to O W.G O No. O H2015206420 B-AWARD to O Z.M.D O The B-ORG focal I-ORG point I-ORG Project I-ORG of I-ORG Hebei I-ORG medical I-ORG research I-ORG No.20130543 O to O Y.L.G O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81400306 O Project B-ORG of I-ORG Medicine I-ORG and I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2014KYA175 O Project B-ORG of I-ORG Invigorating I-ORG Health I-ORG Care I-ORG through I-ORG Science I-ORG Technology I-ORG and I-ORG Education I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Medical I-ORG Youth I-ORG Talent I-ORG QNRC2016671 O The O authors O take O full O responsibility O for O the O study O work O including O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O manuscript O writing O The O content O is O solely O the O responsibility O of O the O authors O and O does O not O represent O the O official O views O of O grant O providers O Present O work O was O financially O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32102027 O Anhui B-ORG Natural I-ORG Science I-ORG Youth I-ORG Foundation I-ORG 2108085QC144 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Education I-ORG Department I-ORG of I-ORG Anhui I-ORG Province I-ORG KJ2021A0143 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Agricultural I-ORG University I-ORG 2020zd17 O Shennong B-ORG New I-ORG Talent I-ORG Project I-ORG of I-ORG Anhui I-ORG Agricultural I-ORG University I-ORG rc352102 O and O Talent B-ORG Introduction I-ORG and I-ORG Stabilization I-ORG Project I-ORG of I-ORG Anhui I-ORG Agricultural I-ORG University I-ORG rc352006 O This O work O was O supported O by O the O Wellcome B-ORG Trust I-ORG Principal I-ORG Fellowship I-ORG 101896 O European B-ORG Research I-ORG Council I-ORG Advanced I-ORG Grant I-ORG 323113-NETSIGNAL O Medical B-ORG Research I-ORG Council I-ORG UK I-ORG G0900613 O Biology B-ORG and I-ORG Biotechnology I-ORG Research I-ORG Council I-ORG UK I-ORG BB/J001473/1 O European O Commission O Marie O Curie O Action O ITN O EXTRABRAIN O 606950 O N.B O was O supported O by O King B-ORG Saud I-ORG University I-ORG funded I-ORG by I-ORG Saudi I-ORG Government I-ORG Scholarship I-ORG KSU1546 O M.R O was O supported O by O a O Wellcome B-ORG Trust I-ORG Investigator I-ORG Award I-ORG 204832/B/16/Z O M.R O and O A.B O were O supported O by O the O MRC B-ORG MR/M008908/1 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 62104159 B-AWARD 12274303 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Top I-ORG Talent I-ORG of I-ORG SZTU I-ORG Grant O No. O GDRC202104 B-AWARD Education B-ORG Department I-ORG of I-ORG Guangdong I-ORG Province I-ORG Grant O No. O 2021KCXTD045 B-AWARD Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG Grant O No. O 2019A1515011673 B-AWARD This O work O was O granted O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81272779 O 81372667 I-AWARD 81472363 I-AWARD 81402301 I-AWARD 81402408 I-AWARD 81572423 I-AWARD 81672500 I-AWARD 81773094 I-AWARD 81772967 I-AWARD 81874085 I-AWARD 81874066 I-AWARD 81802925 I-AWARD 81903011 I-AWARD 81903008 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2019kfyRCPY032 O 2012QN224 I-AWARD 2013ZHYX003 I-AWARD 01-18-530112 I-AWARD 01-18-530115 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG 2014CFA012 O This O work O was O supported O partly O by O the O National B-ORG Sciences I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 11504192 B-AWARD 11674187 B-AWARD 11604172 B-AWARD 11704211 B-AWARD the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG BSB2014010 B-AWARD BS2015SF003 O and O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2015M570570 B-AWARD The O study O was O supported O by O the B-ORG Research I-ORG Special I-ORG Fund I-ORG for I-ORG Public I-ORG Welfare I-ORG Industry I-ORG of I-ORG Health I-ORG from I-ORG National I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG the I-ORG People’s I-ORG Republic I-ORG of I-ORG China I-ORG 201002010 O to O MZ O National B-ORG Key I-ORG Technology I-ORG R&D I-ORG Program I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2011BAI10B01 O to O MZ O the B-ORG University I-ORG of I-ORG Michigan I-ORG Health I-ORG System-Peking I-ORG University I-ORG Health I-ORG Science I-ORG Center I-ORG Joint I-ORG Institute I-ORG for I-ORG Translational I-ORG and I-ORG Clinical I-ORG Research I-ORG BMU20140479 O to O LZ O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81641122 B-AWARD to O JW) O and O Northern/Pacific B-ORG Universities I-ORG Global I-ORG Health I-ORG Research I-ORG Training I-ORG consortium I-ORG of I-ORG National I-ORG Institutes I-ORG of I-ORG Health I-ORG No. O R25 B-AWARD TW009345 I-AWARD to O JW O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O authors O are O grateful O for O the O financial O support O from O Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG CAFS I-ORG 2017JBFZ05 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31572617 O Science B-ORG I-ORG Technology I-ORG Supporting I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BE2016308 O China B-ORG Agriculture I-ORG Research I-ORG System-48(CARS-48 O Fund B-ORG of I-ORG Independent I-ORG Innovation I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG of I-ORG Jiangsu I-ORG province I-ORG CX O 15)1012-4 O Science B-ORG and I-ORG Technology I-ORG Development I-ORG Fund I-ORG of I-ORG Wuxi I-ORG CLE02N1514 O This O work O was O supported O by O grants O from O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFA0103100 O No. B-AWARD 2017YFA0103103 O No. B-AWARD 2017YFA0103104 O Guangzhou B-ORG Health I-ORG Care I-ORG and I-ORG Cooperative I-ORG Innovation I-ORG Major I-ORG Project I-ORG No. B-AWARD 201803040005 O Nature B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81800103 O No. B-AWARD 81872553 O and O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG No. O 201604020007 O This O study O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81370719 O 81671535 O Jiangsu B-ORG Key I-ORG Discipline I-ORG of I-ORG Human I-ORG Assisted I-ORG Reproduction I-ORG Medicine I-ORG Foundation I-ORG FXK201749 O Jiangsu B-ORG Provincial I-ORG Medical I-ORG Talent I-ORG of I-ORG the I-ORG Project I-ORG of I-ORG Invigorating I-ORG Healthcare I-ORG through I-ORG Science I-ORG Technology I-ORG and I-ORG Education I-ORG ZDRCA2016044 O Chinese B-ORG Medical I-ORG Association I-ORG Clinical I-ORG Medicine I-ORG Research I-ORG Reproductive I-ORG Medicine I-ORG 17020270696 O and O Suzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Plan I-ORG Project I-ORG SS2019067 O Wellcome B-ORG Trust O Grant/Award O Number O WT B-AWARD 203148/Z/16/Z O British B-ORG Heart I-ORG Foundation O Grant/Award O Number O TG/18/2/33768 B-AWARD European B-ORG Association I-ORG of I-ORG National I-ORG Metrology I-ORG Institutes O Grant/Award O Number O 15HLT05 B-AWARD UK O Medical B-ORG Research I-ORG Council O Grant/Award O Number O MR/P01979X/1 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 52174183 O Scientific B-ORG Research I-ORG Project I-ORG of I-ORG Guangdong I-ORG Provincial I-ORG Department I-ORG of I-ORG Education—Young I-ORG Innovative I-ORG Talents I-ORG Project I-ORG 2022KQNCX141 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province I-ORG 2019-MS-162 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 52278430 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2022MD713805 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG for I-ORG Key I-ORG Research I-ORG Program I-ORG of I-ORG Tibet I-ORG No. O XZ202101ZR0046G B-AWARD Tibet B-ORG Tianlu I-ORG Innovation I-ORG and I-ORG Development I-ORG Fund I-ORG No. O XZ B-AWARD 2019TL-G-05 O This O research O was O supported O by O grants O from O the O National B-ORG Institute I-ORG of I-ORG Health I-ORG R01 O NS103998 I-AWARD and O K25 B-AWARD HL150305 O the O National B-ORG Multiple I-ORG Sclerosis I-ORG Society I-ORG RG-1902-33633 O and O Pfizer O C.W O was O supported O by O a O Research O Scientist O Award O from O the O American B-ORG Society I-ORG of I-ORG Neuroradiology I-ORG ASNR O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O No. O 31772320 B-AWARD the O Chongqing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O cstc2018jcyjA0947 B-AWARD the O Chongqing B-ORG Social I-ORG Enterprise I-ORG and I-ORG People’s I-ORG Livelihood I-ORG Guarantee I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Special I-ORG Project I-ORG cstc2017shms-zdyfx0025 O and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O XDJK2019C059 B-AWARD and O XDJK2017D088 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O review O was O supported O by O Guizhou B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG Qian O Ke O He O Ping O Tai O Ren O Cai O 2018 B-AWARD 5254 O 2018 B-AWARD 5781 O Qian O Ke O Zhong O Yin O Di O 2022 B-AWARD 4033 O Qian O Ke O He O Zhicheng O 2022 B-AWARD Zhongdian I-AWARD 007 O Qian O Ke O He O Zhicheng O 2021 B-AWARD yiban175 O Qian O Ke O He O Jichu O 2019]1071 B-AWARD Qian O Ke O He O Zhicheng O 2020 B-AWARD 1Y171 O Establishment B-ORG of I-ORG Guizhou I-ORG Modern I-ORG Agriculture I-ORG Industry I-ORG Technical I-ORG System I-ORG Characteristic O Coarse O Cereals O Qian B-AWARD Cai I-AWARD Nong I-AWARD 2018]81 I-AWARD and O Key B-ORG Agricultural I-ORG Technology I-ORG Extension I-ORG Project I-ORG of I-ORG Guizhou I-ORG Province I-ORG [2017 O 106 O This O research O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2022YFD1301004 O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG ASTIP-IAS12 O and O the O Ministry B-ORG of I-ORG Modern I-ORG Agro-Industry I-ORG Technology I-ORG Research I-ORG System I-ORG of I-ORG China I-ORG CARS-36 O This O research O was O partly O supported O by O the O MSIT B-ORG Ministry O of O Science O and O ICT O Korea O under O the O ICAN O ICT O Challenge O and O Advanced O Network O of O HRD O program O IITP-2022-RS-2022-00156345 O 33.3 O and O the O Next B-ORG Generation I-ORG AI I-ORG for I-ORG Multi-purpose I-ORG Video I-ORG Search I-ORG 2021-0-02067 O 33.3 O supervised O by O the O IITP O Institute O of O Information O O Communications O Technology O Planning O O Evaluation O This O research O was O partly O supported O by O the O National O Research O Foundation O of O Korea O NRF O grant O funded O by O the O Korean B-ORG government I-ORG MSIT O 2020R1C1C1008068 O 33.3 O This O work O was O supported O by O the O Key B-ORG Scientific I-ORG and I-ORG Technological I-ORG Grant I-ORG of I-ORG Zhejiang I-ORG for I-ORG Breeding I-ORG New I-ORG Agricultural I-ORG Varieties I-ORG No: O 2021C02069-8 B-AWARD Exploratory B-ORG Disruptive I-ORG Innovation I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Institute I-ORG of I-ORG Freshwater I-ORG Fisheries I-ORG No: O 2022TSX01 B-AWARD and O 2021TSX02 B-AWARD and O “San B-ORG Nong I-ORG Liu I-ORG Fang” I-ORG Science I-ORG and I-ORG Technology I-ORG collaboration I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No: O 2021SNLF026 B-AWARD This O work O was O supported O by O grants O to O J.A.L O from O the O Spanish O Government O Secretaría B-ORG de I-ORG Estado I-ORG de I-ORG Investigación I-ORG Desarrollo I-ORG e I-ORG Innovación I-ORG MINECO O BFU2014-58999-P B-AWARD Galician O Government O Consellería B-ORG de I-ORG Cultura I-ORG Educación I-ORG e I-ORG Ordenación I-ORG Universitaria I-ORG Xunta I-ORG de I-ORG Galicia I-ORG GPC2015/022 O and O European B-ORG Regional I-ORG Development I-ORG Fund I-ORG FP7-316265-BIOCAPS O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21801007 O the O Projects B-ORG of I-ORG Chongqing I-ORG Education I-ORG Board I-ORG CXQT21037 O KJQN201901428 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG Project I-ORG of I-ORG Chongqing I-ORG CSTC I-ORG 2022NSCQ-MSX0304 O and O the O Fuling B-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG Project I-ORG 2021ABB1041 O This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China O grant O No. O 2018YFE0118900 B-AWARD the O Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Commission O grant O No. O JCYJ20200109110001818 B-AWARD the O Guangdong B-ORG Provincial I-ORG Key I-ORG S&T I-ORG Program O grant O No. O 2018B030336001 B-AWARD and O the O Shenzhen-Hong B-ORG Kong I-ORG Institute I-ORG of I-ORG Brain I-ORG Science-Shenzhen I-ORG Fundamental I-ORG Research I-ORG Institutions O grant O No. O 2022SHIBS0003 B-AWARD This O research O was O supported O by O the O Australian B-ORG Research I-ORG Council I-ORG linkage O project O LP160101626 B-AWARD the O Australian B-ORG National I-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG 1078901 O 1113400 B-AWARD and O the O University O of O Queensland O Deputy O Vice O Chancellor O Research O Award O to O support O Complex O Trait O Genomics O The O Irish O analysis O was O funded O by O a O Science B-ORG Foundation I-ORG Ireland I-ORG principal O investigator O award O 14/IA/2576 O and O research O grants O from O the O Science O Foundation O Ireland O and O the O Department O of O Agriculture O Food O and O Marine O on O behalf O of O the O Government O of O Ireland O 16/RC/3835 O VistaMilk O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Project O No. O 41422105 B-AWARD to O YJW O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Project O No. O BK20130050 B-AWARD to O YJW O and O the B-ORG Knowledge I-ORG Innovation I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG ISSASIP1612 O to O YJW O This O work O was O funded O by O the O Kootenai B-ORG Tribe I-ORG of I-ORG Idaho I-ORG Bonneville I-ORG Power I-ORG Administration I-ORG Project I-ORG No. O 1988-064-00 B-AWARD Intergovernmental B-ORG Contract O No. O 74960 B-AWARD and O University B-ORG Project I-ORG Nos O 18-4212 B-AWARD 19-2256 B-AWARD to O A.E.T B-ORG and I-ORG the I-ORG California I-ORG Agricultural I-ORG Experimental I-ORG Station I-ORG of I-ORG the I-ORG University I-ORG of I-ORG California I-ORG Davis I-ORG grant O numbers O CA-D-ASC-2252-H B-AWARD and O CA-D-ASC-2253-RR B-AWARD to O A.E.T O This O work O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Regional I-ORG Innovation I-ORG and I-ORG Development I-ORG U19A2003 O National B-ORG Major I-ORG Scientific I-ORG and I-ORG Technological I-ORG Special I-ORG Project I-ORG for I-ORG “Significant I-ORG New I-ORG Drugs I-ORG Development” I-ORG No. O 2018ZX09733001 O the O Excellent B-ORG Youth I-ORG Foundation I-ORG of I-ORG Sichuan I-ORG Scientific I-ORG Committee I-ORG Grant I-ORG in I-ORG China I-ORG No. O 2019JDJQ008 O and O the O Development B-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFA0201402 O This O research O was O funded O by O Macau B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Fund I-ORG FDCT/0099/2021/A2 O FDCT/0004/2020/A B-AWARD University B-ORG of I-ORG Macau I-ORG MYRG2022-00260-ICMS O CPG2023-00025-ICMS B-AWARD and O SRG2022-00042-ICMS B-AWARD Guangdong-Hong B-ORG Kong-Macau I-ORG Joint I-ORG Lab I-ORG on I-ORG Chinese I-ORG Medicine I-ORG and I-ORG Immune I-ORG Disease I-ORG Research I-ORG EF006/ICMS-CX/2021/GDSTC O Applied B-ORG Research I-ORG Programs I-ORG of I-ORG Guangdong-Hong I-ORG Kong-Macao I-ORG Innovation I-ORG Center I-ORG sponsored O by O Guangzhou O Development O District O EF032/ICMS-CX/2021/RITH O This O work O was O supported O by O funding O from O Science B-ORG Foundation I-ORG Ireland I-ORG 08-IN1-B1853 O and O 12/1A/1294 B-AWARD the O Health B-ORG Research I-ORG Board I-ORG of I-ORG Ireland I-ORG HRB/POR/2012/101 O and O Breast B-ORG Cancer I-ORG Campaign I-ORG 2013MaySP022 O This O material O is O also O based O upon O works O supported O by O the O Irish B-ORG Cancer I-ORG Society I-ORG Collaborative O Cancer O Research O Centre O grant O CCRC13GAL B-AWARD This O research O was O funded O by O grants O PAI B-AWARD 77170004-2017 I-AWARD to O R.B.-S O FONDECYT B-AWARD 11201267 I-AWARD to O R.B.-S O FONDECYT B-AWARD 1211477 I-AWARD to O M.C O and O FONDAP B-AWARD 15130011 I-AWARD to O M.C O from O Agencia B-ORG Nacional I-ORG de I-ORG Investigación I-ORG y I-ORG Desarrollo I-ORG ANID O Chile O and O by O the O University B-ORG of I-ORG Chile I-ORG grant O UI-006/19 B-AWARD to O R.B.-S O and O by O the O Department B-ORG of I-ORG Nutrition I-ORG and I-ORG Public I-ORG Health I-ORG University I-ORG of I-ORG Bío-Bío I-ORG C.C O 20503000 B-AWARD to O L.B.-S O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 11604111 B-AWARD No. O 11675060 B-AWARD and O No. O 91730301 B-AWARD the O Huazhong B-ORG Agricultural I-ORG University I-ORG Scientific I-ORG and I-ORG Technological I-ORG Self-innovation I-ORG Foundation I-ORG Program I-ORG Grant O No.2015RC021 O and O the B-ORG fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central-Universities I-ORG Grant O No.2662018JC017 O The O funding O bodies O played O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 52175031 B-AWARD Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG Grant O No. O 2021YFN0021 B-AWARD Sichuan B-ORG Province I-ORG Information I-ORG Application I-ORG Support I-ORG Software I-ORG Engineering I-ORG Technology I-ORG Research I-ORG Center I-ORG Open I-ORG Project I-ORG Grant O No. O 2021RJGC-Z01 B-AWARD and O Sichuan B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Miao O Zi O Project O Grant O No. O 2022103 B-AWARD This O research O was O funded O by O VA B-ORG Merit I-ORG I01 O BX005413 I-AWARD to O KLB O and O BX005886 B-AWARD to O TAW O T.A.W O is O the O recipient O of O a O Research O Career O Scientist O Award O IK6 O BX005962 O from O the O Department B-ORG of I-ORG Veterans I-ORG Affairs O A.M O is O the O recipient O of O the O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG Fellowship I-ORG Award I-ORG Funding O Reference O Number O 202012MFE-458423-251980 B-AWARD The O present O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81400154 B-AWARD the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grant O No. O BK20151211 B-AWARD the B-ORG Project I-ORG of I-ORG Invigorating I-ORG Health I-ORG Care I-ORG through I-ORG Science I-ORG Technology I-ORG and I-ORG Education I-ORG Jiangsu I-ORG Provincial I-ORG Medical I-ORG Youth I-ORG Talent I-ORG Grant O No. O QNRC2016725 B-AWARD the B-ORG Foundation I-ORG of I-ORG health I-ORG Care I-ORG Rejuvenation I-ORG by I-ORG Science I-ORG and I-ORG education I-ORG Grant O No. O kjxw2015002 B-AWARD the B-ORG Science I-ORG and I-ORG Technology I-ORG plan I-ORG projects I-ORG of I-ORG Suzhou I-ORG Grant O No. O SYSD2016071 B-AWARD This O research O was O supported O by O Establishment B-ORG and I-ORG Demonstration I-ORG of I-ORG the I-ORG Technical I-ORG Model I-ORG of I-ORG Reducing I-ORG the I-ORG Use I-ORG of I-ORG Fertilizer I-ORG and I-ORG Pesticide I-ORG on I-ORG Greenhouse I-ORG Vegetables I-ORG in I-ORG the I-ORG Cold I-ORG Region I-ORG of I-ORG Northeast I-ORG China I-ORG 2016YFD0201004 O a O subproject O of O the O National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG and I-ORG Economic I-ORG Crops I-ORG vegetable I-ORG in I-ORG the I-ORG Heilongjiang I-ORG Province I-ORG Modern I-ORG Agriculture I-ORG Industry I-ORG Technology I-ORG Innovation I-ORG system I-ORG HNWJZT201701 O and O Northeast B-ORG Agricultural I-ORG University I-ORG Young I-ORG Talent I-ORG Project I-ORG 16QC05 O This O research O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC1302204 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81972357 O 81872071 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Chongqing I-ORG cstc2019jcyj-zdxmX0033 O cstc2018jcyjAX0330 B-AWARD and O Chongqing B-ORG University I-ORG Innovation I-ORG Team I-ORG Building I-ORG Program I-ORG funded I-ORG projects I-ORG CXTDX201601010 O This O project O was O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82073923 O 81773988 B-AWARD 81973488 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG Grant O No. O 2017YFC1701600 B-AWARD 2017YFC1701605 B-AWARD Anhui B-ORG Province I-ORG Fungus I-ORG medicine I-ORG research I-ORG and I-ORG development I-ORG “115” I-ORG industry I-ORG innovation I-ORG team I-ORG Anhui O Talent I-AWARD Office I-AWARD 2020 I-AWARD No. I-AWARD 4), O the O Local B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Demonstration I-ORG Project I-ORG Grant O No. O 201907d07050002 B-AWARD the O Key B-ORG Project I-ORG of I-ORG the I-ORG Natural I-ORG Science I-ORG Foundation I-ORG for I-ORG the I-ORG Higher I-ORG Education I-ORG Institutions I-ORG of I-ORG Anhui I-ORG Province I-ORG GXXT-2020-025(10-4 O GXXT-2019-043 B-AWARD KJ2019A0451 B-AWARD KJ2020A0382 B-AWARD The O research O leading O to O these O results O has O received O funding O from O AIRC B-ORG under O MFAG O 2019—ID O 23271 B-AWARD project—P.I O Leanza O Luigi O This O work O was O also O supported O by O grants O from O the O Supporting O Talent O in O Research O O University B-ORG of I-ORG Padova—PROGRAMME O 2021 O Proposal O number:494876 O to O L.L O and O PRID O 2017 O grant O no. O BIRD162511 B-AWARD from O the O University O of O Padova O The O authors’ O work O was O also O supported O by O the O Italian B-ORG Association I-ORG for I-ORG Cancer I-ORG Research I-ORG AIRC O IG O grants O 15544 B-AWARD and O 20286 B-AWARD to O I.S O and O the O Italian B-ORG Ministry I-ORG of I-ORG University I-ORG and I-ORG Education I-ORG PRIN O 2015795S5W B-AWARD to O I.S O This O work O was O sponsored O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61673193 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG JUSRP51635B O JUSRP51510 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017M621625 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20150159 O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFA0301300 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O Nos.61671090 O and I-AWARD 61875021 O Fund B-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Information I-ORG Photonics I-ORG and I-ORG Optical I-ORG Communications I-ORG IPOC20172204 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Beijing I-ORG 2192036 O This O work O was O supported O by O Medtronic O National B-ORG Key I-ORG Clinical I-ORG Specialities I-ORG Construction I-ORG Program I-ORG of I-ORG China I-ORG No. O 2012]121 O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2013B021800313 O and O Special B-ORG Funds I-ORG for I-ORG the I-ORG Cultivation I-ORG of I-ORG Guangdong I-ORG College I-ORG Students I-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG pdjha0094 O This O work O was O supported O by O the O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG grant O number O 300576/2010-2 B-AWARD Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG grant O number O 88881.068515/2014-01 B-AWARD Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo I-ORG grant O number O 2020/08409-9 B-AWARD and I-AWARD 2018/09868-7 O This O work O was O supported O by: O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 6194041 O Beijing B-ORG Excellent I-ORG Talent I-ORG Training I-ORG Project I-ORG 2017-2019 O Fundamental O Research O Funds O for O the O Central O Universities O NO.2015ZCQ-GX-04 O and O by O National B-ORG Key I-ORG Laboratory I-ORG Opening I-ORG task I-ORG KF2N2014W01-002 O The O design O of O this O study O was O supported O by O The B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG Precision I-ORG Medicine I-ORG Research O No. O 2017YFSF090203 B-AWARD the O measurement O and O collection O of O data O were O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O No. O 81470840 B-AWARD 81873565 B-AWARD 81874265 B-AWARD the O analysis O and O interpretation O of O data O were O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai O No. O 18411966600 B-AWARD the O writing O of O the O manuscript O was O supported O by O the O Xinhua O Hospital B-ORG Research I-ORG Foundation O No. O XH1860 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 71673254 O and O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0909900 O to O guarantee O our O investigation O and O College B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Team I-ORG Support I-ORG Plan I-ORG in I-ORG Henan I-ORG Province(20IRTSTHN028 O provides O funding O support O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.61701409 O the O Natural B-ORG Science I-ORG Basic I-ORG Research I-ORG Plan I-ORG in I-ORG Shaanxi I-ORG Province I-ORG of I-ORG China I-ORG No.2018JQ6005 O the O Aero O Science O Foundation O of O China O No.20182053023 O and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG China I-ORG No.310201911cx041 O This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program O grant O number O 2016YFC1000504 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Provincial I-ORG Universities O grant O number O 2017JCZX49 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Province O grant O number O LH2019C043 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O in O part O by O the O National B-ORG Key I-ORG Research I-ORG I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018ZX10101002-002-007 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 81560338 B-AWARD and I-AWARD U1503283 O and O the O International B-ORG Cooperation I-ORG Projects I-ORG of I-ORG Xinjiang I-ORG BINGTUAN I-ORG No. O 2016AH001 B-AWARD This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81772092 O and O 81972947 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG of O China O Major O Basic O Research O Program O ZR2019ZD38 O “Academic B-ORG Elevation I-ORG Program” I-ORG of I-ORG Shandong I-ORG First I-ORG Medical I-ORG University I-ORG Shandong O Academy O of O Medical O Sciences O 2019LJ005 O and O Jinan O Clinical O Research O Center O for O Tissue O Engineering O Skin O Regeneration O and O Wound O Repair O This O research O was O funded O by O Yunnan B-ORG Fundamental I-ORG Research I-ORG Projects I-ORG 202201AU070205 O 202201AU070072 B-AWARD the O Project B-ORG of I-ORG Yunnan I-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG Science I-ORG Research I-ORG Fund I-ORG 2021J0167 O 2022J0503 B-AWARD Foundation B-ORG of I-ORG Yunnan I-ORG Agricultural I-ORG Basic I-ORG Research I-ORG 202101BD070001-126 O 202101BD070001-033 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 3221101545 O and O the O Opening B-ORG Project I-ORG of I-ORG Key I-ORG Laboratory I-ORG for I-ORG Forest I-ORG Resources I-ORG Conservation I-ORG and I-ORG Utilization I-ORG in I-ORG the I-ORG Southwest I-ORG Mountains I-ORG of I-ORG China I-ORG Ministry I-ORG of I-ORG Education I-ORG KLESWFU-202009 O KLESWFU-202010 B-AWARD KLESWFU201903 B-AWARD This O project O was O funded O by O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2017M613176 B-AWARD No. O 2017M613177 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81601898 B-AWARD and O the O Research B-ORG Foundation I-ORG of I-ORG Xi’an I-ORG Hong-Hui I-ORG Hospital I-ORG No. O YJ2016013 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Project O Nos O 61234006 B-AWARD and O 61674024 B-AWARD and O in O part O by O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG 02 I-ORG under O Project O No. O 2013ZX02308-005 B-AWARD in O part O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG China O under O project O Grant O No. O 2015A030311016 B-AWARD in O part O by O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG under O project O ZYGX2016J211 B-AWARD and O in O part O by O the O opening O project O of O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Electronic I-ORG Thin I-ORG Films I-ORG and I-ORG Integrated I-ORG Devices I-ORG under O Grant O KFJJ201609 B-AWARD This O work O was O supported O by O the O Jürgen B-ORG Manchot I-ORG Stiftung I-ORG and I-ORG the I-ORG von I-ORG Behring I-ORG Röntgen I-ORG Stiftung I-ORG under O Grant B-AWARD 66-0008 I-AWARD and O 66-0020 O DFG B-ORG Priority I-ORG Programm I-ORG SPP1656 I-ORG under O Grant B-AWARD STE I-AWARD 776/3-1 I-AWARD and I-AWARD BL I-AWARD 953/5-2 O The O work O was O also O supported O by O the O LOEWE B-ORG Center I-ORG DRUID I-ORG Projects O C4 I-AWARD to I-AWARD US) O within O the O Hessian O Excellence O Program O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81972172 B-AWARD the B-ORG Shanghai I-ORG Municipal I-ORG Health I-ORG Commission I-ORG grant O number O 2017BR026 B-AWARD and O the B-ORG Shanghai I-ORG Hospital I-ORG Development I-ORG Center I-ORG grant O number O SHDC12018122 B-AWARD This O work O was O supported O in O part O by O Dongguan B-ORG Innovative I-ORG Research I-ORG Team I-ORG Program I-ORG under O Grant O 201536000100031 B-AWARD in O part O by O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG under O Grant O 2017B090913001 B-AWARD in O part O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O 51805190 B-AWARD in O part O by O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG under O Grant O 2019M650179 B-AWARD and O in O part O by O Guangdong O major O science O and O technology O project O under O Grant O 2019B090919003 B-AWARD This O work O was O funded O by O FP7-BLUEPRINT B-ORG 282510 O PRIN-20152TE5PK O the O Italian O Association O for O Cancer O Research O AIRC-17217 O Regione B-ORG Campania O FASE2-IDEAL B-AWARD POR B-ORG SATIN B-AWARD Lotta O alle O patologie O concologiche O progetto O ONCARE O and O iCURE B-AWARD FESR B-AWARD progetti O retrospettivi O progetto O MERCURIO O Università O della O Campania O Luigi O Vanvitelli O progetto O VALERE O Vanvitelli O per O la O Ricerca O BioUp B-AWARD Sagl O Lugano O Switzerland O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 61525305 B-AWARD and O 61625304 B-AWARD the O Shanghai B-ORG Natural I-ORG Science I-ORG Foundation I-ORG grant O numbers O 17ZR1409700 B-AWARD and O 18ZR1415300 B-AWARD the O basic O research O project O of O Shanghai O Municipal O Science O and O Technology O Commission O grant O number O 16JC1400900 O and O the O Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG grant O number O ZR2017BF021 B-AWARD This O work O was O supported O by O the O Economic B-ORG and I-ORG Social I-ORG Research I-ORG Council I-ORG grant O number O ES/J500215/1 B-AWARD to O K.F.A O the O Medical B-ORG Research I-ORG Council I-ORG grant O number O MR/K501402/1 B-AWARD to O L.B O and O The B-ORG Alan I-ORG Turing I-ORG Institute I-ORG EP/N510129/1 O to O P.W.G.T O and O M.S.G O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81700094 B-AWARD and O 91643102 B-AWARD the O Scientific B-ORG Research I-ORG Foundation I-ORG for I-ORG the I-ORG Fujian I-ORG University I-ORG of I-ORG Technology I-ORG Grant O No. O GY-Z17016 B-AWARD and O Australian B-ORG Research I-ORG Council I-ORG Project O ID: O DE180101138 B-AWARD and O DP160101953 B-AWARD This O work O was O partially O funded O by O operating O grants O from O the O Cancer B-ORG Research I-ORG Society/University I-ORG of I-ORG Ottawa I-ORG 24064 B-AWARD Natural B-ORG Sciences I-ORG and I-ORG Engineering I-ORG Research I-ORG Council I-ORG RGPIN-2019-0522 B-AWARD New B-ORG Frontiers I-ORG in I-ORG Research I-ORG Fund I-ORG NFRE-2019-00674 B-AWARD and O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG 175177 B-AWARD to O L.W O This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 81673253 B-AWARD the O Norman B-ORG Bethune I-ORG Program I-ORG of I-ORG Jilin I-ORG University I-ORG 2015227 O the O Projects B-ORG of I-ORG International I-ORG Cooperation I-ORG and I-ORG Exchanges I-ORG NSFC I-ORG no. O 81320108025 B-AWARD and O the O Graduate B-ORG Innovation I-ORG Fund I-ORG of I-ORG Jilin I-ORG University I-ORG 2017161 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Beijing B-ORG Municipal I-ORG Science I-ORG I-ORG Technology I-ORG Commission I-ORG Z161100000516147)National O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81372737)Beijing O Municipal I-ORG Administration I-ORG of I-ORG Hospitals I-ORG Clinical I-ORG Medicine I-ORG Development I-ORG of I-ORG Special I-ORG Funding I-ORG Support I-ORG ZYLX201604 O The O work O was O funded O by O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Grant O No. O XDA20100102 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31672472 B-AWARD National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2014CB138706 O and O the O Program B-ORG for I-ORG Changjiang I-ORG Scholars I-ORG and I-ORG Innovative I-ORG Research I-ORG Team I-ORG in I-ORG University I-ORG IRT_17R50 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2014CB138503 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31622055 O 31571547 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG KYTZ201602 O KJYQ201701 O China O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Cellular O samples O experimental O animal O and O sectional O experiment O reagents O were O supported O by O the O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81801515 O 81801478 B-AWARD partial O experiment O reagents O were O acquired O by O Suzhou B-ORG introduce I-ORG expert I-ORG team I-ORG of I-ORG clinical I-ORG medicine I-ORG SZYJTD201708 O Suzhou B-ORG talent I-ORG training I-ORG program I-ORG GSWS2019005 O and O Suzhou B-ORG Science I-ORG and I-ORG Technology I-ORG for I-ORG People’s I-ORG Livelihood I-ORG SYS2019097 O This O work O was O supported O by O grants O from O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0101000 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31901541 O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG Shanxi I-ORG Province I-ORG 201703D211007 O 201803D221019-5 B-AWARD Technology B-ORG Innovation I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG of I-ORG Shanxi I-ORG province O 2017142 O and O Science B-ORG I-ORG Technology I-ORG Innovation I-ORG Foundation I-ORG of I-ORG Shanxi I-ORG Agricultural I-ORG University I-ORG 2016YJ05 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O is O supported O in O part O by O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Grant O No. O XDBS32040100 B-AWARD China B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 61773380 B-AWARD Beijing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG No. O Z181100001518005 B-AWARD the O National B-ORG Institute I-ORG of I-ORG Health I-ORG 1R01MH117107 O R01EB020407 I-AWARD 1R01EB005846 I-AWARD 1R01MH094524 I-AWARD P20GM103472 I-AWARD P30GM122734 O and O the O National B-ORG Science I-ORG Foundation I-ORG 1539067 O This O research O was O funded O by O the O USDA B-ORG National I-ORG Institute I-ORG of I-ORG Food I-ORG and I-ORG Agriculture O grant O numbers O 2018-68003-27462 B-AWARD 2020-67016-31619 B-AWARD and O 2023-67015-39095 B-AWARD the O Ralph B-ORG F. I-ORG and I-ORG Leila I-ORG W. I-ORG Boulware I-ORG Endowment I-ORG Fund I-ORG and I-ORG Oklahoma I-ORG Agricultural I-ORG Experiment I-ORG Station I-ORG Project O H-3112 B-AWARD I.T O is O also O supported O by O the O Graduate O Research O Training O Initiative O for O Student O Enhancement O G-RISE O from O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG to I-ORG Oklahoma I-ORG State I-ORG University I-ORG T32 O GM140953 O This O work O was O supported O by O the O Seoul B-ORG National I-ORG University I-ORG Hospital I-ORG Research O Fund O grant O 0620160680 B-AWARD the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG at O Ministry O of O Education O Science O and O Technology O grant O 2014R1A1A2A16055218 B-AWARD and O the O Korean B-ORG Healthcare I-ORG Technology I-ORG R&D I-ORG project I-ORG at O the O Ministry O of O Health O O Welfare O grant O HI15C1200 B-AWARD received O by O EK O Choi O This O research O was O funded O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grants O 2021ZD0202500 B-AWARD and O 2021YFA1101801 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32171148 O 31770929 B-AWARD and O 31522029 B-AWARD and O the B-ORG Beijing I-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG Z181100001518001 O and O Z161100000216154 B-AWARD to O H.W O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81872634 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2242016K40025 O and O the O Postgraduate B-ORG Research I-ORG and I-ORG Practice I-ORG Innovation I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG KYCX17_0184 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O is O founded O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0501200 O Guangdong B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG 2014B020202001 O and O the B-ORG earmarked I-ORG fund I-ORG for I-ORG Modern I-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG CARS-35 O This O work O was O supported O by O the O Clinical B-ORG innovator I-ORG Award I-ORG Program I-ORG CIA O 160010 O Flight B-ORG Attendant I-ORG Medical I-ORG Research I-ORG Institute I-ORG Inc I-ORG FAMRI O M.N O U19-Al B-AWARD 125357 I-AWARD M.N O NIH B-AWARD P01 I-AWARD HL132821 I-AWARD M.N O A.L O and O M.S O NIH B-AWARD GM I-AWARD 118819 I-AWARD M.N O and O the O National B-ORG Emphysema I-ORG Foundation I-ORG M.N O R01AI148707 B-AWARD U19AI104317 B-AWARD Y.A.B O Boettcher O Early O Career O Investigator O Grant O and O Cystic O Fibrosis O Foundation O Basic O Sciences O Research O Grant O belong O E.K.V O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81973127 O and O 811502873 B-AWARD National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0908300 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20190083 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O through O Grants O No. O U22B2086 B-AWARD and O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China O grant O number O 2020YFB2010200 B-AWARD and O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project O grant O number O 2017-VII-0003-0096 B-AWARD This O work O was O supported O by O the O grants O from O the O National O Key O Research O and O Development O Program O of O China O No. O 2016YFC0901902 B-AWARD funding O body O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China O Natural O Science O Foundation O of O China O Nos O 61272373 B-AWARD 61572102 B-AWARD and O 61572098 B-AWARD funding O body O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O and O Trans-Century O Training O Program O Foundation O for O the O Talents O by O the O Ministry B-ORG of I-ORG Education I-ORG of I-ORG China I-ORG NCET-13-0084 O funding O body O Ministry O of O Education O of O China O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG number O 51661009 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangxi I-ORG Province I-ORG 2016GXNSFGA380001 O The O authors O would O like O to O thank O the O financial O support O from O the O key O project O of O Guangxi B-ORG Key I-ORG Laboratory I-ORG of I-ORG Information I-ORG Materials I-ORG project O number O 171006-Z B-AWARD Henan B-ORG province I-ORG young I-ORG and I-ORG middle-aged I-ORG health I-ORG science I-ORG and I-ORG technology I-ORG innovation I-ORG talent I-ORG project I-ORG No. O YXKC2021044 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Henan I-ORG Province I-ORG No.212102310661 O Joint B-ORG construction I-ORG project I-ORG of I-ORG Henan I-ORG Medical I-ORG Science I-ORG and I-ORG technology I-ORG research I-ORG plan I-ORG No. O LHGJ20200504 B-AWARD Financial O supports O from O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC1604100 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 21676120 O 31872891 B-AWARD the O 111 O Project O 111-2-06 O the O High-end B-ORG Foreign I-ORG Experts I-ORG Recruitment I-ORG Program I-ORG G20190010083 O the O Program B-ORG for I-ORG Advanced I-ORG Talents I-ORG within I-ORG Six I-ORG Industries I-ORG of I-ORG Jiangsu I-ORG Province I-ORG 2015-NY-007 O the O National O Program O for O Support O of O Top-notch O Young O Professionals O the O Fundamental O Research O Funds O for O the O Central O Universities O JUSRP51504 O the O Project O Funded O by O the O Priority O Academic O Program O Development O of O Jiangsu O Higher O Education O Institutions O Top-notch O Academic O Programs O Project O of O Jiangsu O Higher O Education O Institutions O the O Jiangsu O Province O “Collaborative O Innovation O Center O for O Advanced O Industrial O Fermentation” O Industry O Development O Program O and O the O National B-ORG First-Class I-ORG Discipline I-ORG Program I-ORG of I-ORG Light I-ORG Industry I-ORG Technology I-ORG and I-ORG Engineering I-ORG LITE2018-09 O are O greatly O appreciated O This O study O was O funded O by O the O Project B-ORG of I-ORG Shaanxi I-ORG Social I-ORG Science I-ORG Foundation I-ORG 2017S024 O Research B-ORG Program I-ORG of I-ORG Shaanxi I-ORG Soft I-ORG Science I-ORG 2015KRM117 O Shaanxi O Provincial O Youth O Star O of O Science O and O Technology O the O National B-ORG Program I-ORG for I-ORG Support I-ORG of I-ORG Top-notch I-ORG Young I-ORG Professionals I-ORG and I-ORG China I-ORG Medical I-ORG Board I-ORG 15–227 O The O funding O bodies O had O no O further O involvement O in O the O research O process O This O work O was O supported O by O Fundação B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG a I-ORG Tecnologia I-ORG FCT O Portugal O through O project O PTDC/MEC-ONC/29327/2017 B-AWARD and O CeFEMA B-ORG programmatic I-ORG funding I-ORG UIDB/04540/2020 B-AWARD and O UIDP/04540/2020 B-AWARD and O through O IDMEC B-ORG under O LAETA O project O UIDB/50022/2020 B-AWARD Additional O funding O has O been O received O from O the O Biotechnology O and O Biological O Sciences O Research O Council O BBSRC O the O Medical O Research O Council O MRC O and O Age O UK’s O Disconnected O Mind O project O Authors O S.J.R O S.R.C O D.C.M.L O and O I.J.D O were O supported O by O the O MRC O award O to O CCACE B-ORG MR/K026992/1 O Author O S.R.C O was O supported O by O MRC O grant O MR/M013111/1 B-AWARD Author O I.J.D O is O additionally O supported O by O the O MRC O Dementias B-ORG Platform I-ORG UK I-ORG MR/L015382/1 O The O work O was O also O supported O by O a O Wellcome O Trust O Strategic O Award O “Stratifying O Resilience O and O Depression O Longitudinally” O STRADL O reference O 104036/Z/14/Z B-AWARD Author O X.S O receives O support O from O the O China O Scholarship O Council O Author O L.M.R O was O supported O by O an O Erasmus O Traineeship O Grant O Author O H.C.W O is O supported O by O a O JMAS O SIM O fellowship O from O the O Royal O College O of O Physicians O of O Edinburgh O and O by O an O ESAT O College O Fellowship O from O the O University O of O Edinburgh O Authors O A.M.M O H.C.W O and O S.M.L O gratefully O acknowledge O the O support O of O the O Sackler O Foundation O Author O A.M.M O has O previously O received O grant O support O from O Pfizer O Lilly O and O Janssen O for O work O entirely O unrelated O to O the O data O or O analyses O in O this O study O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81572963 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG 11ZR1407300 O Shanghai B-ORG Pujiang I-ORG Program I-ORG 15PJD008 O National B-ORG Institutes I-ORG of I-ORG Health I-ORG R01 O NS093669 I-AWARD and O R01 B-AWARD NS113832 I-AWARD to O J.C.G O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG grant O number O 61806029 B-AWARD the O Chengdu B-ORG University I-ORG of I-ORG Information I-ORG Engineering I-ORG Research I-ORG Fund I-ORG grant O number O KYTZ201719 B-AWARD and O the O Research O Fund O from O Department B-ORG of I-ORG Education I-ORG of I-ORG Sichuan I-ORG Province I-ORG grant O numbers O 18ZA0089 B-AWARD This O work O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Project O No. O 51708317 B-AWARD to O XG),http://www.nsfc.gov.cn O the O Chinese B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017M621095 O to O XG),http://jj.chinapostdoctor.org.cn/V1/Program3/Default.aspxand O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2016EEB27 O to O XG, O ZR2016EEB38),http://www.sdstc.gov.cn O The O funders O had O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grant O from O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG under O Grant O LY20H070003 O and I-AWARD LQ12H07003 O the O Wenzhou B-ORG Science I-ORG I-ORG Technology I-ORG Bureau I-ORG under O Grant O Y20170047 O and O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG under O Grant O 2016YFC1305202 O The O present O work O was O financially O supported O by O the O Key B-ORG R&D I-ORG and I-ORG promotion I-ORG projects I-ORG in I-ORG Henan I-ORG Province I-ORG in I-ORG 2023 I-ORG scientific O and O technological O breakthrough O Grant O No. O 232102111034 B-AWARD the O introduction B-ORG of I-ORG leading I-ORG talents I-ORG and I-ORG the I-ORG construction I-ORG of I-ORG high-level I-ORG talents I-ORG team I-ORG of I-ORG Henan I-ORG Institute I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG doctoral O research O initiation O fee O Grant O No. O 103020221002/010 B-AWARD the O 2022 B-ORG innovation I-ORG and I-ORG entrepreneurship I-ORG training I-ORG program I-ORG for I-ORG College I-ORG Students I-ORG of I-ORG Henan I-ORG Institute I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Grant O No. O 2022CX035 B-AWARD the O 2023 B-ORG Key I-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG Universities I-ORG in I-ORG Henan I-ORG Province I-ORG Grant O No. O 23B230001 B-AWARD the O Twelfth B-ORG Five-Year I-ORG Plan I-ORG of I-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Projects I-ORG “Research I-ORG and I-ORG Demonstration I-ORG of I-ORG Rapid I-ORG Detection I-ORG Technology I-ORG for I-ORG Hormone I-ORG Drugs” I-ORG Grant O No. O 2014BAD13B05-01 B-AWARD the O Program B-ORG for I-ORG Innovative I-ORG Research I-ORG Team I-ORG in I-ORG Science I-ORG and I-ORG Technology I-ORG in I-ORG University I-ORG of I-ORG Henan I-ORG Province I-ORG Grant O No. O 20IRTSTHN025 B-AWARD and O the O Central B-ORG Plains I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Leading I-ORG Talent I-ORG Project I-ORG Grant O No. O 204200510010 B-AWARD This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China O grant O number O 2019YFC1908204 O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Science O grant O number O XDA21060300 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 22178364 O This O research O is O funded O by O University B-ORG of I-ORG Science O VNU-HCM O under O grant O number O T2022-57 B-AWARD acquired O by O Thien-Luan O Phan O Additionally O we O would O like O to O acknowledge O the O support O in O the O form O of O a O grant O 109-2313-B-005 O 007 I-AWARD ) O from O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Taiwan I-ORG Republic I-ORG of I-ORG China O and O partially O supported O by O a O grant O 111-2221-E-005-018 O from O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Council I-ORG Taiwan I-ORG Republic I-ORG of I-ORG China I-ORG acquired O by O Prof O Congo O Tak O Shing O Ching O Moreover O this O research O is O also O partially O supported O by O grant O 112ST001H O from O National B-ORG Chung I-ORG Hsing I-ORG University I-ORG Taiwan I-ORG Republic I-ORG of I-ORG China I-ORG acquired O by O Prof O Pin-Chi O Tang O This O research O was O funded O by O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O grant O number O NRF-2016R1A5A1011974 B-AWARD Key B-ORG Lab I-ORG of I-ORG Marine I-ORG Bioactive I-ORG Substance I-ORG and I-ORG Modern I-ORG Analytical I-ORG Technique I-ORG SOA O grant O number O MBSMAT-2019-02 B-AWARD Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation O grant O number O ZR2019BD027 B-AWARD National O Natural O Science O Foundation O of O China O grant O number O 31900031 O Open O Research O Fund O Program O of O Shandong O Provincial O Key O Laboratory O of O Glycoscience O and O Glycotechnology O Ocean O University O of O China O grant O number O KLGGOUC201703 B-AWARD Study O is O supported O by O grants O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2019YFC1604900 O Major B-ORG Natural I-ORG Science I-ORG Research I-ORG Projects I-ORG of I-ORG Colleges I-ORG and I-ORG Universities I-ORG in O Jiangsu O Province O 22KJA360010 O and O the O Postgraduate B-ORG Research I-ORG and I-ORG Practice I-ORG Innovation I-ORG Program I-ORG of O Jiangsu O Province O No. O 1812000024885 B-AWARD Austrian B-ORG Science I-ORG Fund I-ORG FWF O and O Herzfelder'sche O Familienstiftung O P30623-B26 O to O M.S O joint O D-A-CH O project O ‘The O role O of O specialized O ribosomes O in O stress O resistance O and O healthy O aging’ O by O Deutsche B-ORG Forschungsgemeinschaft I-ORG DFG O 280594475 O to O M.K O Austrian O Science O Fund O FWF O I2514 O to O J.G O and O Swiss B-ORG National I-ORG Science I-ORG Foundation I-ORG SNF O 310030E-162559/1 O to O N.P O F.N O is O a O fellow O of O the O international O PhD O programme O ‘BioToP-Biomolecular O Technology O of O Proteins’ O funded O by O the O Austrian O Science O Fund O FWF O W1224 O to O J.G O Funding O for O open O access O charge O Austrian O Science O Fund O FWF O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 32122084 B-AWARD Chongqing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O cstc2020jcyj-bshX0092 B-AWARD cstc2021ycjh-bgzxm0005 B-AWARD PhD B-ORG Start-up I-ORG Foundation I-ORG of I-ORG Southwest I-ORG University I-ORG No. O SWU120012 B-AWARD and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG Central I-ORG Universities I-ORG no. O SWU-KT22042 B-AWARD This O research O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Province I-ORG 1908085QE218 O the O University B-ORG Natural I-ORG Science I-ORG Research I-ORG Project I-ORG of I-ORG Anhui I-ORG Province I-ORG Grant O Nos O KJ2019A0852 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 51871085 B-AWARD and O 51571078 B-AWARD the O Program O of O College O Students O Innovation O of O Laboratory O Construction O 2016ckjh116 O and O the O Research O Funds O for O High-level O Talents O of O Bengbu O University O Grant O No. O BBXY2018KYQD14 O This O research O was O supported O by O grants O K01ES025434 B-AWARD awarded O by O NIEHS B-ORG through O funds O provided O by O the O trans-NIH O Big O Data O to O Knowledge O BD2K O initiative O http://www.bd2k.nih.gov O P20 B-AWARD COBRE I-AWARD GM103457 I-AWARD awarded O by O NIH/NIGMS B-ORG NICHD B-AWARD R01 I-AWARD HD084633 I-AWARD and O NLM B-AWARD R01LM012373 I-AWARD and O Medical O Research O Grant O 14ADVC-64566 B-AWARD from O Hawaii B-ORG Community I-ORG Foundation I-ORG to O LX O Garmire O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81302197 O Changzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG CE20165048 O Changzhou B-ORG High-Level I-ORG Medical I-ORG Talents I-ORG Training I-ORG Project I-ORG 2016CZBJ006 O Changzhou B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Major I-ORG Scientific I-ORG and I-ORG Technological I-ORG Project I-ORG ZD201620 O Changzhou B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Youth I-ORG Talent I-ORG Scientific I-ORG and I-ORG Technological I-ORG Project I-ORG QN201807 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20181156 O Our O discussion O emerged O from O a O National B-ORG Science I-ORG Foundation-funded I-ORG Seed I-ORG Dispersal I-ORG Workshop I-ORG DEB O 1548194 B-AWARD held O at O the O National O Socio-Environmental O Synthesis O Center O in O May O 2016 O D.Z O received O funding O from O the O Swiss B-ORG National I-ORG Science I-ORG Foundation I-ORG SNF O grant B-AWARD PZ00P3_168136/1 O and O from O the O German B-ORG Science I-ORG Foundation I-ORG DFG O grant O ZU B-AWARD 361/1-1 O J.B O received O funding O from O CEH B-ORG National I-ORG Capability I-ORG NEC06895 B-AWARD This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51805460 B-AWARD Science O and O Technology O Planning O Project O of O Fujian O Province O No. O 2019H0038 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2018A030313522 B-AWARD Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Shenzhen I-ORG Municipality I-ORG in O China O No. O JCYJ20180306173000073 B-AWARD Xiamen O Science O and O Technology O Planning O Project O No. O 3502Z2019015 O This O project O is O supported O by O three O funding O sources O RGC O Seed O fund O for O basic O research O University O Grant O Council O HK O SAR O Government O entitled O “Survey O of I-ORG the I-ORG attitudes I-ORG and I-ORG needs I-ORG of I-ORG integrated I-ORG HIV I-ORG and I-ORG STI I-ORG services I-ORG in I-ORG community I-ORG health I-ORG centres I-ORG in I-ORG China I-ORG 2015-16).” O Project O Number O 201411159004 B-AWARD Shanghai B-ORG Key I-ORG Discipline I-ORG Construction I-ORG Program I-ORG in I-ORG Public I-ORG Health I-ORG Shanghai O Municipal O Commission O of O Health O and O Family O Planning O Project O Number O 12GWZX1001 B-AWARD and O Shanghai B-ORG Excellent I-ORG Academic I-ORG Leaders I-ORG Training I-ORG Program I-ORG in I-ORG Public I-ORG Health I-ORG Shanghai O Municipal O Commission O of O Health O and O Family O Planning O Project O Number O GWDTR201210 B-AWARD The O funding O bodies O did O not O have O any O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O Grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81673447 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 19ykpy36 B-AWARD Pioneering B-ORG talents I-ORG project I-ORG of I-ORG Guangzhou I-ORG Development I-ORG Zone I-ORG Guangdong I-ORG Province I-ORG No. O CY2018-012 B-AWARD Leading B-ORG team I-ORG for I-ORG entrepreneurship I-ORG in I-ORG Guangzhou I-ORG Guangdong I-ORG Province I-ORG No. O 201809020004 B-AWARD National B-ORG Major I-ORG Scientific I-ORG and I-ORG Technological I-ORG Special I-ORG Project I-ORG for I-ORG Significant I-ORG New I-ORG Drugs I-ORG Development I-ORG No. O 2018ZX09733002 B-AWARD Guangzhou B-ORG people's I-ORG Livelihood I-ORG Science I-ORG and I-ORG technology I-ORG tackling I-ORG key I-ORG project I-ORG No. O 201803010113 B-AWARD The O work O was O supported O in O part O by O the O National B-ORG Planning I-ORG Office I-ORG of I-ORG Philosophy I-ORG and I-ORG Social I-ORG Science I-ORG 14BGL141 B-AWARD to O Chengsen O He; O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Tianjin I-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG CN) I-ORG 11601001 B-AWARD to O Jiuchang O Wei O Excellent B-ORG Young I-ORG Talents I-ORG Fund I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG Institutions I-ORG of I-ORG Anhui I-ORG Province I-ORG CN) I-ORG KJ2016A369 B-AWARD KJ2016A368 I-AWARD and I-AWARD KJ2016A372 I-AWARD to O Jiangjie O Sun O Humanities B-ORG and I-ORG Social I-ORG Science I-ORG Research I-ORG Projects I-ORG of I-ORG Key I-ORG Base I-ORG in I-ORG Sichuan I-ORG Provincial I-ORG SCYG2018-10 B-AWARD to O Jiangjie O Sun O This O research O was O funded O by O the B-ORG Local I-ORG Innovative I-ORG and I-ORG Research I-ORG Teams I-ORG Project I-ORG of I-ORG Guangdong I-ORG Pearl I-ORG River I-ORG Talents I-ORG Program O grant O number O 2019BT02N054 B-AWARD the B-ORG Basic I-ORG Research I-ORG I-ORG Applying I-ORG Basic I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O grant O number O 2019B1515210007 B-AWARD and O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 31572565 B-AWARD This O work O was O supported O by O the O National B-ORG Research I-ORG Foundation I-ORG NRF I-ORG of I-ORG Korea I-ORG NRF-2021R1A5A6002853 O and O NRF-2020R1A2B5B01001949 B-AWARD and O the O Korea O Health O Technology O R&D O Project O through O the O Korea B-ORG Health I-ORG Industry I-ORG Development I-ORG Institute I-ORG KHIDI O funded O by O the O Ministry O of O Health O O Welfare O HI21C16390212782127670003 O This O work O was O also O partially O funded O by O the O BK21 O FOUR O program O of O NRF O Korea O and O the O Korea B-ORG Institute I-ORG for I-ORG Advancement I-ORG of I-ORG Technology I-ORG KIAT O and O the O Ministry O of O Trade O Industry O O Energy O MOTIE O of O the O Republic O of O Korea O No. O P0017363 O The O study O was O supported O by O the B-ORG Technology I-ORG Fund I-ORG for I-ORG Youth I-ORG of I-ORG Sichuan I-ORG #2017JQ0056 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG #41671041 O the B-ORG earmarked I-ORG fund I-ORG for I-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG #CARS-35-35 O the B-ORG state I-ORG key I-ORG research I-ORG and I-ORG development I-ORG program I-ORG in I-ORG the I-ORG 13th I-ORG five-year I-ORG #2016YFC0502601 O This O work O was O supported O by O fellowships O and O grants O from O the O following O agencies O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG do I-ORG Ensino I-ORG Superior I-ORG CAPES O PRODOC B-AWARD 2709/2010 O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq O 308285/2014-0 O 457499/2014-1 B-AWARD 312066/2014-7 B-AWARD Fundo B-ORG de I-ORG Apoio I-ORG ao I-ORG Ensino I-ORG à I-ORG Pesquisa I-ORG e I-ORG Extensão I-ORG da I-ORG Unicamp I-ORG FAEPEX-PEC2012 O 1578/12 B-AWARD Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo I-ORG FAPESP O proc O 2012/03144-0 B-AWARD 2014/03791-1 B-AWARD Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG Minas I-ORG Gerais I-ORG FAPEMIG O APQ-01525-14 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51508150 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG E2018402206 O The B-ORG provincial I-ORG support I-ORG plans I-ORG for I-ORG the I-ORG top I-ORG of I-ORG the I-ORG notch I-ORG youth I-ORG talents I-ORG of I-ORG Hebei I-ORG BJ2017034 O Our O work O was O supported O by O the O Key B-ORG Scientific I-ORG Research I-ORG Projects I-ORG of I-ORG Advanced I-ORG Education I-ORG Institutions I-ORG of I-ORG Department I-ORG of I-ORG Education I-ORG of I-ORG Henan I-ORG Province I-ORG 19A320006 O in O part O by O the O Health B-ORG and I-ORG Family I-ORG Planning I-ORG Technology I-ORG Overseas I-ORG Training I-ORG Project I-ORG of I-ORG Henan I-ORG Province I-ORG 2018028 O and O in O part O by O the O Youth B-ORG Innovation I-ORG Fund I-ORG Project I-ORG of I-ORG the I-ORG First I-ORG Affiliated I-ORG Hospital I-ORG of I-ORG Zhengzhou I-ORG University I-ORG 201418 O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81774389 O and O 81303039 B-AWARD to O Y.L.J O the O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG LQ17H270003 O to O X.F.H O the O Specialized B-ORG Research I-ORG Fund I-ORG for I-ORG the I-ORG Doctoral I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG 20133322120001 O to O Y.L.J O and O the O Zhejiang B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG BSH1302083 O to O Y.L.J O This O work O was O supported O by O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. O 2023C03046 B-AWARD the O Medical B-ORG and I-ORG Health I-ORG Research I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. O 2022KY765 B-AWARD the O Research B-ORG Project I-ORG of I-ORG Jinan I-ORG Microecological I-ORG Biomedicine I-ORG Shandong I-ORG Laboratory I-ORG No. O JNL-2022026C B-AWARD and O JNL-2023003C B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 2022ZFJH003 B-AWARD This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61673143 O 31671187 B-AWARD the O Scientific B-ORG Fund I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG for I-ORG Youth I-ORG QC2015100 O the O Wuliande B-ORG Foundation I-ORG of I-ORG Harbin I-ORG Medical I-ORG University I-ORG WLD-QN1707 O and O the O University B-ORG Nursing I-ORG Program I-ORG for I-ORG Young I-ORG Scholars I-ORG with I-ORG Creative I-ORG Talents I-ORG in I-ORG Heilongjiang I-ORG Province I-ORG UNPYSCT-2016197 O This O work O was O supported O by O FP7-People-IRSES B-ORG “APHIWEB” I-ORG 611810 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31330064 O and O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Cotton I-ORG Biology I-ORG Open I-ORG Fund I-ORG of I-ORG China I-ORG CB2016A09 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O internally B-ORG funded I-ORG award O No. O DN10017 B-AWARD Authors O N.D O and O A.C.’s O work O was O supported O by O the O National B-ORG Institute I-ORG on I-ORG Deafness I-ORG and I-ORG Other I-ORG Communication I-ORG Disorders I-ORG award O No. O R01DC013318 B-AWARD Authors O C.N O and O J.A.’s O work O was O supported O by O the O National B-ORG Aeronautics I-ORG and I-ORG Space I-ORG Administration I-ORG grant O No. O 80NSSC21M0309 B-AWARD issued O through O the O NASA O Office O of O STEM O Engagement O We O would O like O to O acknowledge O the O support O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG no. O 2022YFE0107400 B-AWARD Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Committee I-ORG no. O 20DZ2220500 B-AWARD Shanghai O Science O and O Technology O Committee O no. O 21NL2600100 B-AWARD the O equipment B-ORG research I-ORG and I-ORG development I-ORG projects I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG no. O GJJSTD20210006 B-AWARD This O study O was O supported O by O theNational O Institutes I-ORG of I-ORG Neurologic I-ORG Disorders I-ORG and I-ORG Stroke I-ORG NINDS)grant O R01 B-AWARD NS055903 O theNational O Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences I-ORG NCATS)grant O 1U54TR001356 B-AWARD theUniversity O of I-ORG Iowa I-ORG Clinical I-ORG and I-ORG Translational I-ORG Science I-ORG Award1U54TR001013 O and O theCHDI O Foundationgrant O 071108 B-AWARD The O funders O had O no O role O in O study O design O data O collection O data O analysis O interpretation O or O writing O of O the O report O National O Key O R&D O Program O of O China O 2016YFA0301300 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61675237 O 91750207 I-AWARD 11761141015 O the B-ORG Guangdong I-ORG Special I-ORG Support I-ORG Program I-ORG 2017TQ04C487 O the O Guangdong O Natural O Science O Funds O for O Distinguished O Young O Scholars O 2017B030306007 O the O Pearl O River O S&T O Nova O Program O of O Guangzhou O 201806010033 O the O Guangdong O Natural O Science O Foundation O 2016A030312012 O and O the O Science O and O Technology O Projects O of O Guangzhou O 201607020023 O 201805010004 I-AWARD and I-AWARD 201804010175 O The O National B-ORG Research I-ORG Foundation I-ORG Singapore I-ORG and O the O National O Natural O Science O Foundation O of O China O NSFC O Joint O Grant O NRF2017NRF-NSFC002-015 B-AWARD National O Research O Foundation O Singapore O Grant O No. O NRF2016-NRF-ANR002 B-AWARD A*STAR B-ORG SERC I-ORG Grant O No. O A1685b0005 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81703321 B-AWARD 61902319 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No. O 3102017OQD098 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG Grant O No. O 2019JQ127 B-AWARD This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81201902 B-AWARD Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG No. O 19ZR1409600 B-AWARD the O Shanghai B-ORG Engineering I-ORG and I-ORG Research I-ORG Center I-ORG of I-ORG Diagnostic I-ORG and I-ORG Therapeutic I-ORG Endoscopy I-ORG No. O 16DZ228 B-AWARD 0900 O This O study O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program(Grant O No. O 2019YFD1001904 O and O 2018YFD1000200 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31972368 B-AWARD Agriculture B-ORG Research I-ORG System I-ORG of I-ORG China I-ORG Grant O No. O CARS-29-yc-6 B-AWARD Natural B-ORG Science I-ORG Founds I-ORG of I-ORG Liaoning I-ORG Province I-ORG Grant O No. O 2019-MS-280 B-AWARD Shenyang B-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG Funds I-ORG Grant O No. O 19-302-3-10 B-AWARD and O the B-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Liaoning I-ORG Province I-ORG Grant O No. O 2020JH5/10100023 B-AWARD This O work O was O supported O by O the O Korean O Government O MSIP O through O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF,https://www.nrf.re.kr/eng/main O NRF-2016R1E1A1A01941152 O to O S-JVL O by O KBRI O basic O research O program O through O Korea O Brain O Research O Institute O funded O by O Ministry B-ORG of I-ORG Science I-ORG and I-ORG ICT I-ORG 19-BR-03-03 O to O CMH O and O by O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG CIHR,http://www.cihr-irsc.gc.ca/e/193.html O PJT-153199 O to O ST. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O by O grants O of O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81771825 O Beijing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG D171100003017003 O and O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG China I-ORG 2017YFC1307904 O This O work O was O supported O by O the O Universiti B-ORG Kebangsaan I-ORG Malaysia I-ORG UKM O project O grant O code O DIP-2020-009 B-AWARD This O work O was O also O supported O by O Grant O NPRP12S-0227-190164 B-AWARD from O the O Qatar B-ORG National I-ORG Research I-ORG Fund O a O member O of O Qatar O Foundation O Doha O Qatar O and O student O grant O from O Qatar B-ORG University O Grant O O QUST-1-CENG-2023-796 B-AWARD The O claims O made O herein O are O solely O the O responsibility O of O the O authors O Open O access O publication O is O supported O by O Qatar O National O Library O This O paper O is O partly O supported O by O 1) O Academy B-ORG of I-ORG Finland I-ORG via O a) O FIREMAN O consortium O n.326270 O as O part O of O CHIST-ERA O grant O CHIST-ERA-17-BDSI-003 B-AWARD b) O EnergyNet B-ORG Fellowship I-ORG n.321265/n.328869/n.352654 B-AWARD and O c) O X-SDEN B-ORG project I-ORG n.349965 B-AWARD 2) O Jane O and O Aatos O Erkko O Foundation O via O STREAM O project O 3) O by O CNPq B-ORG Grant O 311470/2021-1 B-AWARD 4) O by O São O Paulo O Research O Foundation O FAPESP O Grant O No. O 2021/06946-0 B-AWARD and O 5) O by O RNP B-ORG with O resources O from O MCTIC O Grant O No. O 01245.010604/2020-14 B-AWARD under O the O Brazil O 6G O project O of O the O Radiocommunication O Reference O Center O Centro O de O Referência O em O Radiocomunicações—-CRR O of O the O National O Institute O of O Telecommunications O Instituto O Nacional O de O Telecomunicações—Inatel O Brazil O 5) O It O was O also O supported O by O the O Science O Foundation O Ireland O under O grant O 13/RC/2077_P2 O CONNECT O This O research O was O funded O by O “Key O science I-ORG and I-ORG Technology I-ORG project I-ORG of I-ORG Hainan I-ORG Province I-ORG ZDKJ202018)” O “GuangDong O Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG 2023A1515011840)” O “Key-Area O Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2020B1111030005)” O “National O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 22037006 O 82022067)” B-AWARD “Local O Innovation I-ORG and I-ORG Entrepreneurship I-ORG Team I-ORG Project I-ORG of I-ORG Guangdong I-ORG 2019BT02Y262)” O “Open O program I-ORG of I-ORG ShenZhen I-ORG Bay I-ORG Laboratory I-ORG SZBL2021080601006)” O “Nansha O District I-ORG Science I-ORG and I-ORG technology I-ORG award I-ORG NSJL202102)” O and O “Fundamental O Research I-ORG I-ORG Applied I-ORG Fundamental I-ORG Research I-ORG Major I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2019B030302004)” O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Major I-ORG Foundation I-ORG of I-ORG Research I-ORG Instrumentation I-ORG of I-ORG China I-ORG Grant O No. O 61427808 B-AWARD by O the O Key B-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 61333009 B-AWARD and O in O part O by O the O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2012CB821204 B-AWARD in O part O by O the O Natural O Sciences O and O Engineering O Research O Council O of O Canada O NSERC O under O Grant O RGPIN239031 O This O study O was O supported O by O a O grant O from O the O Polish B-ORG National I-ORG Centre I-ORG of I-ORG Sciences I-ORG granted O under O decision O No. O DEC-2012/07/B/ST5/03035 B-AWARD and O by O the O Polish B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Higher I-ORG Education I-ORG under O the O KNOW B-AWARD program O The O calculations O were O carried O out O using O resources O provided O by O the O Polish B-ORG Grid I-ORG Infrastructure I-ORG PL-Grid O and O Wrocław O Center O for O Networking O and O Supercomputing O Bem O cluster I-AWARD WCSS I-AWARD Grant I-AWARD No. I-AWARD 327/2014 O The O author(s O disclose O receipt O of O the O following O financial O support O for O the O research O authorship O and/or O publication O of O this O article O This O article O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82260217 O Jiangxi B-ORG Nature I-ORG Science I-ORG Foundation I-ORG 20142BAB205036 O 20212BAG70013 B-AWARD 20192BBGL70025 B-AWARD Health B-ORG Commission I-ORG of I-ORG Jiangxi I-ORG Province I-ORG 202310267 O 202210447 B-AWARD and O Central B-ORG Funds I-ORG Guiding I-ORG Local I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG 20221ZDG020066 O French B-ORG government I-ORG ‘Investissements I-ORG d’Avenir’ I-ORG project O OCEANOMICS O ANR-11-BTBR-0008 O to O P.H O T.V O C.V O M.L O E.P O ‘Agence O Nationale I-ORG de I-ORG la I-ORG Recherche’ O project O IMPEKAB O ANR-15-CE02-0011 O to O E.V O ETH O Zurich O and O Helmut O Horten O Foundation O to O S.S O European B-ORG Regional I-ORG Development I-ORG Fund I-ORG project O FEDER O 1166-39417 O Funding O for O open O access O charge O French O government O ‘Investissements O d’Avenir’ O project O OCEANOMICS O ANR-11-BTBR-0008 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61701166 O National O Key O R&D O Program O of O China O No. O 2018YFC1508106 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 2018B16314 O Nantong O Science O and O Technology O Project O No. O MS12017026-2 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2018M632215 O Science B-ORG Fund I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG of I-ORG Jiangxi I-ORG Province I-ORG under I-ORG Grant I-ORG No.2018ACB21029 O Young O Elite O Scientists O Sponsorship O Program O by O CAST O No. O 2017QNRC001 O National O Science O Foundation O for O Young O Scientists O of O China O No. O 51709271 O This O work O was O supported O by O a O grant O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 21402122 B-AWARD It O was O also O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG No. O 14ZR1440600 B-AWARD and O the O Scientific B-ORG Research I-ORG Foundation I-ORG for I-ORG the I-ORG Returned I-ORG Overseas I-ORG Chinese I-ORG Scholars I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG PRC I-ORG No. O ZX2015-9 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 51662027 B-AWARD 51602170 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Qinghai O China O Grant O No.2016-ZJ-954Q O and O Chun B-ORG Hui I-ORG Program I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG Grant O No. O Z2016074 B-AWARD Z2016075 B-AWARD This O research O was O fund O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O 52105038 B-AWARD the O Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG under O Grant O JSGG20201103094400002 B-AWARD the O Shenzhen B-ORG Fundamental I-ORG Research I-ORG Project I-ORG under O Grant O JCYJ20200109115639654 B-AWARD This O research O was O funded O by O the O Zhejiang B-ORG Provincial I-ORG Medical I-ORG and I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG under O grant O number O WKJ-ZJ-2331 B-AWARD awarded O to O S.Z O the O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O grant O number O LY23C070002 B-AWARD awarded O to O W.W O and O the O Hangzhou B-ORG Medical I-ORG and I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG under O grant O number O A20200827 B-AWARD awarded O to O Y.X O This O research O was O funded O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Grant O Number O 2018YFD0900304–5 B-AWARD for O Prof O Ziping O Zhang O who O conceived O the O study O and O designed O the O experiments O checked O and O modified O the O manuscript O Discipline B-ORG Development I-ORG Grant I-ORG from I-ORG College I-ORG of I-ORG Animal I-ORG Sciences I-ORG FAFU I-ORG 712018R0404 O for O Mr. O Xin O Zhang O who O conducted O the O experiments O and O wrote O the O manuscript O Open O fund O project O of O Fujian O Engineering O Research O Center O of O Aquatic O Breeding O and O Healthy O Aquaculture O DF20902 O for O Mr. O Xin O Zhang O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 41176152 B-AWARD for O Prof O Yilei O Wang O who O conceived O the O study O and O designed O the O experiments O and O checked O and O modified O the O manuscript O Special O Fund O for O Marine O Economic O Development O of O Fujian O Province O Grant O Number O ZHHY-2019-3 O for O Prof O Ziping O Zhang O International O Science O and O Technology O Cooperation O and O Communication O Grant O of O Fujian O Agriculture O and O Forestry O University O Grant O Number O KXGH17019 O for O Prof O Ziping O Zhang O and O 13th O Five-year O Plan O on O Fuzhou O Marine O Economic O Innovation O and O Development O Demonstration O City O Project O FZHJ17 O for O Prof O Ziping O Zhang O This O study O was O supported O by O fund O from O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31902067 O and O 31501694 B-AWARD the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Provincial I-ORG Grant O No. O 2022J01138 B-AWARD the B-ORG Foundation I-ORG of I-ORG Fujian I-ORG Science I-ORG and I-ORG Technology I-ORG Committee I-ORG Grant O No. O 2018N0003 B-AWARD the B-ORG Foundation I-ORG of I-ORG Fuzhou I-ORG Science I-ORG and I-ORG Technology I-ORG Committee I-ORG Grant O No. O 2017NF30048 B-AWARD This O study O was O partly O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81661148056 B-AWARD National O Science O and O Technology O Major O Project O grant O number O 2017ZX10304401 O National O Key O Research O and O Development O Program O grant O number O 2016YFC0903700 O Guangzhou O Health O Care O and O Cooperative O Innovation O Major O Project O grant O number O 20174020229 O Guangzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG Key I-ORG Projects I-ORG grant O number O 201904020037 B-AWARD Guangdong B-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG grant O numbers O 2016A020250001 B-AWARD and O 2016A02048001 B-AWARD the O Key O Research O and O Development O Program O of O Guangdong O Province O grant O number O 2019B020218004 O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61872337 B-AWARD and O No. O 62132019 B-AWARD the O National B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2019YQ1700 B-AWARD and O the O Swiss B-ORG National I-ORG Science I-ORG Foundation I-ORG NRP75 I-ORG project I-ORG 407540_167266 B-AWARD This O study O is O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFA0503100 O to O JC, O Beijing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG Z181100001518005 O to O EY, O and O Peking B-ORG University I-ORG Medicine I-ORG Fund I-ORG of I-ORG Fostering I-ORG Young I-ORG Scholars’ I-ORG Scientific I-ORG I-ORG Technological I-ORG Innovation I-ORG to O EY O BMU2018PY008 O This O research O was O funded O by O the B-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG Shandong I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG CXGC2022E18 O and O the B-ORG Special I-ORG Foundation I-ORG for I-ORG Distinguished I-ORG Taishan I-ORG Scholar I-ORG of I-ORG Shangdong I-ORG Province I-ORG No.ts201712057 O the O Project O of O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Fund I-ORG in I-ORG Shandong I-ORG Province I-ORG 2019LY002 O 2019YQ010 B-AWARD the O Project O of O Improved B-ORG Agricultural I-ORG Varieties I-ORG in I-ORG Shandong I-ORG Province I-ORG 2020LZGC010 O This O work O was O supported O by O the O Special B-ORG Fund I-ORG for I-ORG Talents I-ORG of I-ORG China I-ORG Three I-ORG Gorges I-ORG University I-ORG 1910103 O the O Science B-ORG and I-ORG Technology I-ORG Bureau I-ORG of I-ORG Guangzhou I-ORG City I-ORG School I-ORG college I-ORG co-funded I-ORG Project I-ORG 202201020296 O and O the O Guangdong B-ORG Provincial I-ORG Hospital I-ORG of I-ORG Chinese I-ORG Medicine I-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Program I-ORG YN2019MJ11 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O MCB O was O supported O through O the O National O Institute O of O Health O NIH O National B-ORG Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute I-ORG R01 B-AWARD HL088511 I-AWARD https://www.nhlbi.nih.gov O MCB O was O supported O by O NIH O National B-ORG Institute I-ORG on I-ORG Drug I-ORG Abuse I-ORG K24 B-AWARD DA037804-01 I-AWARD drugabuse.gov O and O JDW O was O supported O by O NIH O National B-ORG Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences I-ORG KL2 B-AWARD TR001856 I-AWARD https://www.nhlbi.nih.gov O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 31302106 B-AWARD the O Open B-ORG Funds I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Veterinary I-ORG Etiological I-ORG Biology I-ORG no. O SKLVEB2013KFKT009 B-AWARD and O the O Research B-ORG and I-ORG Development I-ORG Foundation I-ORG of I-ORG Henan I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG no. O 2015ZDCXY04 B-AWARD This O research O was O funded O by O the O American B-ORG Institute I-ORG for I-ORG Cancer I-ORG Research O 585363 B-AWARD the O American B-ORG Cancer I-ORG Society I-ORG CRP-19-175-06-COUN B-AWARD and O the O National B-ORG Cancer I-ORG Institute O P01 B-AWARD CA229997 I-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O grants O 42106103 B-AWARD and O U22A20112 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG under O grants O 2021M693210 B-AWARD and O 2022T150654 B-AWARD the O Project B-ORG of I-ORG Special I-ORG Funds I-ORG for I-ORG Marine I-ORG Economic I-ORG Development I-ORG in I-ORG Fujian I-ORG Province I-ORG under O Grant O FJHJF-L-2022-20 B-AWARD and O the O MEL-RLAB B-ORG Program I-ORG 202101 O The O project O is O partly O sponsored O by O the O Construct O Program O of O the O Key O Discipline O in O Hunan O province O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.61640210 O No.61672447 B-AWARD the O CERNET B-ORG Next I-ORG Generation I-ORG Internet I-ORG Technology I-ORG Innovation I-ORG Project I-ORG No. O NGII20160305 O the O Science B-ORG I-ORG Education I-ORG Joint I-ORG Project I-ORG of I-ORG Hunan I-ORG Natural I-ORG Science I-ORG Foundation I-ORG No.2017JJ5036 O and O the O Upgrading B-ORG Project I-ORG of I-ORG Industry-University I-ORG Research I-ORG of I-ORG Xiangtan I-ORG University I-ORG No.11KZ|KZ03051 O This O work O was O supported O by O the O National B-ORG Institute I-ORG of I-ORG Child I-ORG Health I-ORG and I-ORG Human I-ORG Development I-ORG NICHD O R01 B-AWARD HD045639 O National B-ORG Institute I-ORG on I-ORG Aging I-ORG NIA O 1F32 O AR061238 O National B-ORG Science I-ORG Foundation I-ORG NSF-DMS B-AWARD 0928587 O and O the O U.S B-ORG Army I-ORG Research O Institute O for O the O Behavioral O and O Social O Sciences O W5J9CQ-12-C-0046 O DS O was O also O supported O by O a O visiting O scientist O appointment O at O the O Max-Planck O Institute O for O Intelligent O Systems O in O Tübingen O Germany O Any O opinions O findings O and O conclusions O or O recommendations O expressed O in O this O material O are O those O of O the O authors O and O do O not O necessarily O reflect O the O views O of O the O funding O organizations O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O a O Jiangsu B-ORG Province I-ORG Shuangchuang I-ORG Ph.D I-ORG award I-ORG JSSCBS20211276 O the O S B-ORG I-ORG T I-ORG Program I-ORG of I-ORG Hebei I-ORG Grant O no.21323602D O and O Jiangsu B-ORG Province I-ORG Xuzhou I-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG KC20194 O for O the O present O work O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O nos O 81902117 B-AWARD and O 81971993 B-AWARD the O Shanghai B-ORG Sailing I-ORG Program I-ORG grant O no. O 19YF1431300 B-AWARD and O Research B-ORG Project I-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Health I-ORG Commission I-ORG grant O no. O 20194Y0318 B-AWARD The O National O Natural O Science O Foundation O of O China O grant O no. O 81902117 O and O Shanghai O Sailing O Program O grant O no. O 19YF1431300 O funded O the O design O of O the O study O sample O collection O related O experiments O and O collection O of O case O records O The O National O Natural O Science O Foundation O of O China O grant O no. O 81971993 O and O Research O Project O of O Shanghai O Municipal O Health O Commission O grant O no. O 20194Y0318 O funded O data O analysis O interpretation O of O data O and O writing O and O revision O of O the O manuscript O The O funding O body O had O no O role O in O the O design O of O the O study O the O collection O analysis O and O interpretation O of O data O or O in O the O writing O of O the O manuscript O This O research O was O funded O by O PPR2 B-ORG MESFCRS-CNRST I-ORG 2017 I-ORG Morocco I-ORG Grant O No: O PPR2-2016-59 B-AWARD and O bilateral B-ORG cooperation I-ORG between I-ORG Morocco I-ORG and I-ORG Tunisia I-ORG CNRST-2020 O We O also O thank O the O Moroccan B-ORG Ministry I-ORG of I-ORG Higher I-ORG Education I-ORG Scientific I-ORG Research I-ORG and I-ORG Innovation/OCP I-ORG Foundation/APRD I-ORG research I-ORG program I-ORG 2021 I-ORG Grant O No: O APRD-2021 B-AWARD This O work O was O supported O by O the B-ORG National I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2012CB947602 O the B-ORG National I-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31300887 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20130299 O Suzhou B-ORG Clinical I-ORG Research I-ORG Center I-ORG of I-ORG Neurological I-ORG Disease I-ORG Szzx201503 O and O Jiangsu B-ORG Provincial I-ORG Special I-ORG Program I-ORG of I-ORG Medical I-ORG Science I-ORG BL2014042 O The O Commonwealth B-ORG Scholarship I-ORG Commission I-ORG NGCA-2015-051 O provided O funding O for O the O doctoral O studentship O of O OAE O JC O and O CF O are O funded O by O grants O from O the O Bill B-ORG and I-ORG Melinda I-ORG Gates I-ORG Foundation I-ORG OPP O 1033751 O We O acknowledge O joint O Centre O funding O from O the O UK O Medical B-ORG Research I-ORG Council I-ORG and O Department O for O International O Development O – O grant O reference O MR/R015600/1 B-AWARD The O funders O played O no O role O in O the O study O design O data O collection O formal O analysis O interpretation O of O results O and O decision O to O publish O this O study O This O study O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0501603 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31872492 O and O 31902251 B-AWARD and O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M643107 O Funding O for O this O study O was O provided O by O the O Norwegian B-ORG Foundation I-ORG for I-ORG Health I-ORG and I-ORG Rehabilitation I-ORG grants I-ORG 59010-2000/2001/2002 B-AWARD Norwegian B-ORG Cancer I-ORG Society I-ORG grant I-ORG 05087 B-AWARD and I-AWARD TP I-AWARD 49 I-AWARD 258 O South-East B-ORG Norwegian I-ORG Health I-ORG Authority I-ORG grant I-ORG 2012064 B-AWARD Norwegian B-ORG Research I-ORG Council I-ORG grant I-ORG 213997 B-AWARD This O work O was O supported O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China(grant O 81822034 O and O grant O 81773119 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China(grant O 2018YFA0109200 O and O grant O 2017YFA0106800 O Sichuan B-ORG Science-Technology I-ORG International I-ORG Cooperation I-ORG Project I-ORG grant O 2019YFH0144 O and O Direct B-ORG Scientific I-ORG Research I-ORG Grants I-ORG from I-ORG West I-ORG China I-ORG Second I-ORG Hospital I-ORG Sichuan I-ORG University(grant O KS021 O This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG No. O B2016405026 B-AWARD Young B-ORG Elitist I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG No. O BJ2016003 B-AWARD Hebei B-ORG North I-ORG University I-ORG PhD I-ORG startup I-ORG fund I-ORG No. O 12995556 B-AWARD Guide B-ORG projects I-ORG of I-ORG Department I-ORG of I-ORG Education I-ORG of I-ORG Hebei I-ORG province I-ORG No. O Z2019028 B-AWARD and O Hebei B-ORG North I-ORG University I-ORG Fund I-ORG No. O YB2018002 B-AWARD No. O QN2018008 B-AWARD No. O QN2018012 B-AWARD All O funding O bodies O played O no O role O in O the O design O of O the O study O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O paper O was O sponsored O by O the B-ORG Special I-ORG Projects I-ORG in I-ORG Cooperation I-ORG between I-ORG Changchun I-ORG City I-ORG and I-ORG Local I-ORG Universities O 17DY024 B-AWARD the B-ORG Key I-ORG Scientific I-ORG and I-ORG Technological I-ORG Research I-ORG and I-ORG Development I-ORG Projects I-ORG in I-ORG Jilin I-ORG Province O 20180201056YY B-AWARD the B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG the I-ORG 13th I-ORG Five-Year I-ORG Plan I-ORG of I-ORG Jilin I-ORG Provincial I-ORG Department I-ORG of I-ORG Education O JJKH20180236KJ B-AWARD This O publication O is O the O result O of O the O implementation O of O the O projects O ITMS B-AWARD 26240120025 I-AWARD and O 26240220071 B-AWARD supported O by O the O Research B-ORG I-ORG Development I-ORG Operational I-ORG Programme I-ORG which I-ORG is I-ORG funded I-ORG by I-ORG the I-ORG ERDF O Work O was O also O supported O by O the O Slovak B-ORG Research I-ORG and I-ORG Development I-ORG Agency I-ORG under O the O contract O numbers O APVV-15-0466 B-AWARD and O APVV-18-0282 B-AWARD and O by O VEGA B-ORG Agency I-ORG with I-ORG the I-ORG projects I-ORG 2/0059/19 B-AWARD and O 2/0061/17 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O We O acknowledge O the O support O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82173017 B-AWARD Natural B-ORG Science I-ORG Basis I-ORG Research I-ORG Plan I-ORG in I-ORG Shaanxi I-ORG Province I-ORG of I-ORG China I-ORG Program O No. O 2021JQ-337 B-AWARD and O the O Scientific B-ORG and I-ORG Technological I-ORG Innovation I-ORG Major I-ORG Base I-ORG of I-ORG Guangxi I-ORG No.2022-36-Z05 O Guangxi B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG No. O AB20117001 B-AWARD Guangxi B-ORG science I-ORG and I-ORG technology I-ORG bases I-ORG and I-ORG talent I-ORG special I-ORG project I-ORG No. O AD17129062 B-AWARD This O work O was O supported O by O the O following O grants O National B-ORG Institute I-ORG of I-ORG Neurological I-ORG Disorders I-ORG and I-ORG Stroke I-ORG NINDS O RC2NS069409 B-AWARD U01NS086090 B-AWARD U01NS1365885 B-AWARD to O G. O T. O Manley O NS070680 B-AWARD to O B. O E. O Lindquist O United B-ORG States I-ORG Departments I-ORG of I-ORG Defense I-ORG DOD O W81XWH-13-1-0441 B-AWARD W81XWH-14-2-0176 B-AWARD W81XWH-18-2-0042 B-AWARD to O G. O T. O Manley O and O Neurosurgery B-ORG Research I-ORG and I-ORG Education I-ORG Foundation I-ORG I-ORG Bagan I-ORG Family I-ORG Foundation I-ORG Research I-ORG Fellowship I-ORG Grant I-ORG UCSF O Award O A139203 B-AWARD to O J. O K. O Yue O The O funders O had O no O role O in O the O study O design O data O collection O analysis O and O interpretation O writing O of O the O report O and O the O decision O to O submit O the O article O for O publication O Funded O by O National B-ORG Instrumentation I-ORG Program I-ORG http://service.most.gov.cn O Award O Number:2013YQ030629 O Grant O Recipient O Rifeng O Zhou O Chongqing B-ORG University I-ORG Basic I-ORG Scientific I-ORG Research I-ORG Foundation I-ORG Award O Number:CDJZR12120006 O Grant O Recipient O Rifeng O Zhou O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG http://www.nsfc.gov.cn O Award O Number:61471070 O Grant O Recipient O Fenglin O Liu O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Ideas O for O this O manuscript O initiated O during O the O Seed O Dispersal O Workshop O held O in O May O 2016 O at O the O Socio-Environmental O Synthesis O Center O in O Annapolis O MD O and O supported O by O the O US B-ORG National I-ORG Science I-ORG Foundation I-ORG Grant O DEB-1548194 B-AWARD to O N.G.B O and O the O National O Socio-Environmental O Synthesis O Center O under O the O US O National O Science O Foundation O Grant O DBI-1052875 B-AWARD D.Z O received O funding O from O the O Swiss B-ORG National I-ORG Science I-ORG Foundation I-ORG SNF O grant O PZ00P3_168136/1 B-AWARD and O from O the O German B-ORG Science I-ORG Foundation I-ORG DFG O grant O ZU B-AWARD 361/1-1 O This O work O was O supported O by O grants O from O the O UNAM-PAPIIT B-ORG No. O IN218418 B-AWARD INP B-ORG No. O NC123280.0/17073.0 B-AWARD UNAM-PAPIIT O No. O IA200818/IA203220 B-AWARD and O CONACyT B-ORG No. O 295057/256448 B-AWARD This O work O was O supported O by O the O Major B-ORG National I-ORG Research I-ORG and I-ORG Development I-ORG Projects I-ORG 2012ZX10001005-007 O the O National B-ORG High I-ORG Technology I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2012AA02A404 O and O the O State B-ORG Key I-ORG Laboratory I-ORG for I-ORG Infectious I-ORG Disease I-ORG Prevention I-ORG and I-ORG Control I-ORG 2011SKLID103 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O the O National O Center O for O Complementary O and O Integrative O Health O of O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG under O award O number O R00AT006507 B-AWARD the O Brazilian O Federal O Agency O under O CAPES B-ORG award O number O 2317/2014-01 B-AWARD PhD O fellowship O to O BB O and O the O NIH/NIDCR B-ORG Training O grant O under O award O number O T90DE021982 B-AWARD Postdoctoral O fellowship O to O DS O The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O funding O agencies O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG of I-ORG China I-ORG No. O 81625016 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81802352 B-AWARD the O Shanghai B-ORG Sailing I-ORG Program I-ORG No. O 17YF1402500 B-AWARD and O the O Clinical B-ORG and I-ORG Scientific I-ORG Innovation I-ORG Project I-ORG of I-ORG Shanghai I-ORG Hospital I-ORG Development I-ORG Center I-ORG SHDC12018109 O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31772361 O University B-ORG Nursing I-ORG Programme I-ORG for I-ORG Young I-ORG Scholars I-ORG with I-ORG Creative I-ORG Talents I-ORG in I-ORG Heilongjiang I-ORG Province I-ORG UNPYSCT-2015002 O Academic B-ORG Backbone I-ORG Project I-ORG of I-ORG Northeast I-ORG Agricultural I-ORG University I-ORG 17XG05 O and O China B-ORG Agricultural I-ORG Research I-ORG System I-ORG CARS-23-C-10 O This O research O was O funded O by O Venture O O Innovation O Support O Program O for O Chongqing O Overseas O Returnees O No.cx2018098 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O XDJK2019B056 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31601430 B-AWARD and O the B-ORG Special I-ORG Funding I-ORG of I-ORG Chongqing I-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O xm2017046 B-AWARD This O research O was O funded O by O the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2022YFF1203202 O the B-ORG Strategic I-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDA26040304 O XDB38050200 B-AWARD the B-ORG Fund I-ORG of I-ORG the I-ORG Key I-ORG Laboratory I-ORG of I-ORG Tissue I-ORG Microenvironment I-ORG and I-ORG Tumor I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG 202002 O Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG ZR2022MC072 O This O work O was O supported O by O FAPESP B-ORG Fundação I-ORG de I-ORG Amparo I-ORG è I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo I-ORG grant O 2010/19059-7 B-AWARD CJVA B-ORG and O JLO B-ORG received O the O FAPESP O scholarships O 2011/17071-2 B-AWARD and O 2013/10382-8 B-AWARD respectively O PMdAZ O holds O a O CNPq–PQ O scholarship O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O is O supported O by O the O NSFC B-ORG Excellent I-ORG Young I-ORG Scholars I-ORG Program O under O Grants O 61722212 B-AWARD in O part O by O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grants O 61873212 B-AWARD 61861146002 I-AWARD 61732012 O in O part O by O the O West B-ORG Light I-ORG Foundation I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences O Grants O 2017-XBZG-BR-001 B-AWARD The O funder O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O National B-ORG key I-ORG research I-ORG and I-ORG development I-ORG program I-ORG Grant O No. O 2018YFD0400403 B-AWARD and I-AWARD 2016YFD0400802 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O Grant O No. O 31701575 B-AWARD 31571801 O the O Support B-ORG Project I-ORG of I-ORG High-level I-ORG Teachers I-ORG in I-ORG Beijing I-ORG Municipal I-ORG Universities I-ORG in I-ORG the I-ORG Period I-ORG of I-ORG 13th I-ORG Five-year I-ORG Plan I-ORG Grant O No. O CIT&TCD201704042 B-AWARD BTBU O Basic O Scientific O Research O Operating O Fee O in O 2019 O PXM2019-014213-000007 O and O Talent O Training O Quality O Construction-First O Class O Professional O Construction O PXM2019-014213-000010 O Deutsche B-ORG Forschungsgemeinschaft I-ORG SFB1035 O to O M.S O GRK1721 B-AWARD to O M.S O Ministry B-ORG of I-ORG Economy I-ORG and I-ORG Competitiveness I-ORG BFU2015-71017/BMC O MINECO/FEDER O EU O to O I.D.M O Ramon O Areces’ O Foundation O 2015–2017 O to O I.D.M O Andalusian B-ORG Government I-ORG CVI-BIO198 O P11-CVI-7216 B-AWARD to O I.D.M O Health B-ORG Department I-ORG Basque I-ORG Government I-ORG 2013111114 O to O M.L.M.-C O BIOEF O Basque O Foundation I-ORG for I-ORG Innovation I-ORG and I-ORG Health I-ORG Research O EiTB O Maratoia O BIO15/CA/016/BD O to O M.L.M.-C O ELKARTEK O 2016 O and O Ministry O of O Economy O and O Competitiveness O MINECO O SAF2014-54658-R O to O M.L.M.-C O Funding O for O open O access O charge O Technical O University O of O Munich O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21808118 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2018BB065 O and O Qingdao B-ORG Postdoctoral I-ORG Applied I-ORG Research I-ORG Project I-ORG 2018102 O The O research O leading O to O these O results O has O received O funding O from O the O European B-ORG Union I-ORG Seventh I-ORG Framework I-ORG Programme I-ORG FP7/2007-2013 O project O PolyWEC B-ORG under O Grant O Agreement O No. O 309139 B-AWARD from O the O European O Union O Horizon O 2020 O Program O Project O WETFEET B-ORG under O grant O no. O 646436 B-AWARD from O Tuscany O Region O Italy O under O the O project O EOLO O FAR O FAS O 2014-A O This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2021YFC2300103 O 2022YFE0203100 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82271786 O 81971927 B-AWARD and O Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG 20190804095916056 O JSGG20200225152008136 B-AWARD RCJC20210706092009004 B-AWARD The O design O and O data O collection O of O this O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31871624 O Analysis O and O interpretation O of O data O in O this O research O was O supported O by O the O National B-ORG Transgenic I-ORG Key I-ORG Project I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Agriculture I-ORG 2018ZX0800909B O The O manuscript O was O written O with O financial O support O from O the O Talents B-ORG Introduced I-ORG Fund I-ORG of I-ORG Anhui I-ORG Science I-ORG and I-ORG Technology I-ORG University I-ORG NXYJ201604 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51809057 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 3072019CFM0302 O and O the O Low-speed B-ORG Diesel I-ORG Engine I-ORG Project I-ORG for I-ORG High I-ORG Technology I-ORG of I-ORG Ships O CDGC01-KT11 O Financial O support O came O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 51205107 B-AWARD the O Top B-ORG Talents I-ORG Program I-ORG of I-ORG Hebei I-ORG Higher I-ORG Education I-ORG grant O no. O BJ2017011 B-AWARD and O the O Tribology B-ORG Science I-ORG Fund I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Tribology I-ORG grant O no. O SKLTKF16B01 B-AWARD This O work O was O done O with O the O financial O support O of O the O European B-ORG Union I-ORG Horizon I-ORG 2020 I-ORG projects O BioExcel O 675728 O 823830 B-AWARD and O EOSC-hub B-ORG 777536 O and O of O the O Dutch B-ORG Foundation I-ORG for I-ORG Scientific I-ORG Research I-ORG NWO O TOP-PUNT O grant O 718.015.001 B-AWARD This O work O was O financially O supported O through O Grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81001340 O and O 81200509 B-AWARD the O Foundation B-ORG for I-ORG Distinguished I-ORG Young I-ORG Teachers I-ORG in I-ORG Higher I-ORG Education I-ORG of I-ORG Guangdong I-ORG Yq2013079 O the B-ORG Medical I-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O China O A2015211 O and O the B-ORG Department I-ORG of I-ORG Education I-ORG Guangdong I-ORG Government I-ORG under I-ORG the I-ORG TOP-tier I-ORG University I-ORG Development I-ORG Scheme I-ORG for O Research O and O Control O of O Infectious O Diseases O China O Grant O 2015013 B-AWARD This O study O was O supported O by O the O National O Institutes O of O Health O NIH O National B-ORG Institute I-ORG of I-ORG Biomedical I-ORG Imaging I-ORG and I-ORG Bioengineering I-ORG NIBIB O 3R21EB01761101S1 B-AWARD the O Stanford B-ORG Child I-ORG Health I-ORG Research I-ORG Institute I-ORG Transdisciplinary B-AWARD Initiatives I-AWARD Program O and O the O Stanford B-ORG Bio-X I-ORG Graduate B-AWARD Research I-AWARD Fellowship I-AWARD Program O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O work O was O supported O by O a O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31301877 O and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG KJQN201431 O to O AX. O The O comparative O study O withAnopheles O atroparvuswas O supported O by O the O grant O from O the B-ORG Russian I-ORG Science I-ORG Foundation I-ORG № B-AWARD 15-14-20011 I-AWARD to O IVS O The O funding O agencies O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O funded O by O Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Commission I-ORG grant O no. O JCYJ20170307093557440 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou O China O grant O no. O 201804010150 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Bureau I-ORG of I-ORG Guangming O Shenzhen O grant O no. O 2020R01072 B-AWARD This O research O was O supported O by O two O grants O from O the O US O National O Institutes O of O Health O to O S.M.R O grant O R33CA191159 B-AWARD from O the O National B-ORG Cancer I-ORG Institute I-ORG and O grant O P42ES004705 B-AWARD from O the O National B-ORG Institute I-ORG for I-ORG Environmental I-ORG Health I-ORG Sciences O and O a O grant O from O the O Swedish B-ORG Research I-ORG Council I-ORG to O M.T O VR, O 621-2012-4187 B-AWARD This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81572900 O The B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG Central I-ORG South I-ORG University I-ORG No. O 1053320171187 I-AWARD and I-AWARD No. I-AWARD 2018zzts232 O The B-ORG Undergraduate I-ORG Training I-ORG Programs I-ORG for I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG UTPIE O XCX20190537 I-AWARD L. O He O This O research O was O funded O by O National B-ORG Institutes I-ORG of I-ORG Health O 5R01GM104325 B-AWARD National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council O 1118640 B-AWARD Australian B-ORG Research I-ORG Council O LE150100083 B-AWARD Australian O Research O Council O DP120100916 B-AWARD Beijing B-ORG Academy I-ORG of I-ORG Agriculture I-ORG and I-ORG Forestry I-ORG Sciences O GJHZ2017-5 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21307028 O the O Foundation B-ORG of I-ORG Henan I-ORG Province I-ORG 182102310728 O and O the O Program B-ORG for I-ORG Innovative I-ORG Research I-ORG Team I-ORG of I-ORG Henan I-ORG Polytechnic I-ORG University I-ORG T2018-3 O The O present O work O was O supported O by O Key B-ORG research I-ORG and I-ORG development I-ORG plan I-ORG of I-ORG Anhui I-ORG Province I-ORG 1804b06020342 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Province I-ORG 1608085QC46 O Major B-ORG Projects I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG in I-ORG Anhui I-ORG Province I-ORG 17030801036 O Natural O Science O Foundation O of O Anhui O Province O 1908085MB48 O and O Natural O Science O Foundation O of O Anhui O Province O 1908085MB43 O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81871871 B-AWARD 81703056 B-AWARD 81802275 B-AWARD 81702260 B-AWARD Key B-ORG Research I-ORG and I-ORG Development I-ORG plan I-ORG Social I-ORG development I-ORG of I-ORG science I-ORG and I-ORG technology I-ORG department I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No.BE2019760 O the B-ORG Medical I-ORG Innovation I-ORG Team I-ORG Foundation I-ORG of I-ORG the I-ORG Jiangsu I-ORG Provincial I-ORG Enhancement I-ORG Health I-ORG Project I-ORG No. O CXTDA2017021 B-AWARD Project B-ORG 789 I-ORG of I-ORG Excellent I-ORG Talent I-ORG Training I-ORG Program I-ORG of I-ORG The I-ORG Second I-ORG Affiliated I-ORG Hospital I-ORG of I-ORG Nanjing I-ORG Medical I-ORG University I-ORG No.789ZYRC202090148 O This O work O was O supported O by O Fundação B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG Tecnologia I-ORG FCT I-ORG Portugal I-ORG Aga I-ORG Khan I-ORG Development I-ORG Network I-ORG AKDN)—Portugal I-ORG Collaborative I-ORG Research I-ORG Network I-ORG in I-ORG Portuguese I-ORG speaking I-ORG countries I-ORG in I-ORG Africa I-ORG project O 332821690 B-AWARD Inês O Moranguinho O was O supported O by O PhD B-ORG fellowship I-ORG from I-ORG Fundação I-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG Tecnologia I-ORG FCT I-ORG Portugal I-ORG reference O SFRH/BD/131062/2017 B-AWARD Inês O Bártolo O is O supported O by O FCT B-ORG through I-ORG Norma I-ORG Transitória—DL57/2016/CP1376/CT0012 O This O work O was O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG province I-ORG China I-ORG 2015J06006 O and O 2015J05055 B-AWARD the B-ORG Research I-ORG Funds I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scientists I-ORG in I-ORG Fujian I-ORG Agriculture I-ORG and I-ORG Forestry I-ORG University I-ORG xjq201630 O the B-ORG Program I-ORG for I-ORG New I-ORG Century I-ORG Excellent I-ORG Talents I-ORG in I-ORG Fujian I-ORG Province I-ORG University I-ORG JA14095 O the B-ORG earmarked I-ORG fund I-ORG for I-ORG the I-ORG Modern I-ORG Agriculture I-ORG Technology I-ORG of I-ORG China I-ORG CARS-20 O and O Research B-ORG Funds I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scientists I-ORG in I-ORG Fujian I-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG JA13090 O The O research O leading O to O these O results O received O funding O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No O 81600346 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province O China O Grant O No O BK2011162 B-AWARD and O BK20151115 B-AWARD the B-ORG R B-ORG I-ORG D I-ORG Fund I-ORG of I-ORG Wuxi I-ORG Municipal I-ORG Science I-ORG I-ORG Technology I-ORG Bureau O China O Grant O No O CSE00705 B-AWARD CMB21S1301 B-AWARD and O CMB41S1701 B-AWARD and O Jiangsu B-ORG Department I-ORG of I-ORG Health O China O Grant O Nos O H200739 B-AWARD BJ14023 B-AWARD Z201519 B-AWARD BJ15032 B-AWARD BJ15033 B-AWARD and O H201639 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81704101 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG 2015A030313353 O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Guangdong I-ORG 2013A032500009 O The O funding O institutions O were O responsible O for O the O provision O of O literature O database O resources O and O literature O purchase O The O principal O of O the O institution O instructed O in O the O design O of O the O study O and O data O collection O analysis O interpretation O of O data O and O writing O the O manuscript O This O research O was O supported O by O the O Main O Research O Program O E0210602-02 O of O the O Korea B-ORG Food I-ORG Research I-ORG Institute I-ORG KFRI O by O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O grants O NRF-2021R1C1C2010928 O NRF-2019M3E5D3073567 O NRF-2021R1A4A1032114 O NRF-2022R1A2C2013377 O DGIST B-ORG R&D I-ORG program I-ORG 23-CoE-BT-04 O and O by O a O research O grant O from O the O Korea B-ORG Basic I-ORG Science I-ORG Institute I-ORG C230210 O funded O by O the O Ministry O of O Science O and O ICT O This O study O was O supported O by O the O grants O from O the O Joint B-ORG Program I-ORG on I-ORG the I-ORG Science I-ORG and I-ORG Technolog I-ORG Collaboration I-ORG of I-ORG Southwest I-ORG Medical I-ORG University I-ORG and I-ORG the I-ORG Government I-ORG of I-ORG Luzhou I-ORG City I-ORG No. O 2018LZXNYD-PT04 B-AWARD the O Science B-ORG Technology I-ORG Support I-ORG Plan I-ORG Projects I-ORG of I-ORG Luzhou I-ORG No. O 2015LZCYD-S02 B-AWARD and O the O Project B-ORG Program I-ORG of I-ORG Southwest I-ORG Medical I-ORG University I-ORG 2017-ZRQN-005 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O FWF B-ORG Special O Research O Programme O SFB O F44 O F4413-B23 O “Cell O Signaling O in O Chronic O CNS O Disorders” O by O the O FWF O Hertha-Firnberg O Postdoctoral O Programme O no. O T736-B24 B-AWARD PMU-FFF B-ORG A-15/01/017-MAR B-AWARD and O through O funding O from O the O European B-ORG Union’s I-ORG Seventh I-ORG Framework I-ORG Programme O FP7/2007-2013 O under O grant O agreement O no. O HEALTH-F2-2011-278850 B-AWARD INMiND O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 52206141 O Key B-ORG Projects I-ORG of I-ORG Shenzhen I-ORG Technology I-ORG Research I-ORG JSGG20220831101202005 O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG in I-ORG Hubei I-ORG Province I-ORG 2021BCA157 O Doctoral B-ORG Foundation I-ORG of I-ORG Guangxi I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Grant O No. O 18Z13 B-AWARD Shandong B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Small I-ORG and I-ORG Medium-sized I-ORG Enterprises I-ORG Innovation I-ORG Ability I-ORG Improvement I-ORG Project I-ORG Grant O No. O 2022TSGC2519 B-AWARD Guangxi B-ORG Scientific I-ORG Base I-ORG I-ORG Talent I-ORG Special I-ORG Project I-ORG AD20297084 O The O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81572481 B-AWARD to O Ying O Peng O International B-ORG Collaboration I-ORG Program I-ORG of I-ORG Universities I-ORG in I-ORG Guangdong I-ORG Province I-ORG No.2012hjhz001 O and O the B-ORG Key I-ORG Project I-ORG of I-ORG Product I-ORG Study I-ORG and I-ORG Research I-ORG of I-ORG Guangzhou I-ORG city I-ORG No. O 1561000181 B-AWARD to O Ying O Peng O National O Natural O Science O Foundation O of O China O No. O 81502167 B-AWARD to O Xiaoming O Rong O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 42107168 B-AWARD the B-ORG Program I-ORG of I-ORG Shanghai I-ORG Committee I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG China I-ORG 22WZ2503000 O and O the B-ORG Program I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG G2021013020L O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81673179 B-AWARD 81402687 B-AWARD 81602860 O 81703233 O Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Committee I-ORG grant O number O 18140903100 B-AWARD 19140903100 B-AWARD 18140903102 B-AWARD 22Y11906200 B-AWARD the O Shanghai B-ORG Sailing I-ORG Program I-ORG grant O number O 18Y1419600 B-AWARD Shanghai B-ORG Municipal I-ORG Health I-ORG Commission I-ORG grant O number O 20174Y0010 B-AWARD 20184Y0078 B-AWARD This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province O China O under O Grant O 20170540312 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities O China O under O Grants O N181604006 B-AWARD and O N181906001 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grants O 61773110 B-AWARD and O U1908212 B-AWARD The O present O work O was O supported O by O grants O from O the B-ORG BeiJing I-ORG Talents I-ORG Fund I-ORG 2015000021469G204 O the B-ORG Basic I-ORG Medicine I-ORG and I-ORG Clinical I-ORG Medicine I-ORG Cooperation I-ORG Fund I-ORG of I-ORG Capital I-ORG Medical I-ORG University I-ORG 15JL70 O 16JL20 B-AWARD and O the B-ORG Scientific I-ORG Research I-ORG Cultivation I-ORG Fund I-ORG of I-ORG Capital I-ORG Medical I-ORG University I-ORG PYZ19030 O This O work O was O supported O by O a O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG research I-ORG grant O awarded O to O JA, O AN, O SV O and O FS O BB/L021005/1 O a O Sêr B-ORG Cymru I-ORG fellowship I-ORG 80762-CU-080 O to O AR, O a O Wellcome B-ORG Trust I-ORG Strategic I-ORG Award I-ORG 100202/z/12/z O to O Michael O J. O Owen O J.H O Lawrence O Wilkinson O Adrian O Harwood O Meng O Li, O David O Linden O John O Aggleton O Vincenzo O Crunelli O and O Derek O Jones O and O a O Wellcome B-ORG Trust I-ORG ISSF I-ORG Seedcorn I-ORG Award I-ORG 105613/Z/14/Z O to O A.R O S.V O is O funded O by O a O Wellcome B-ORG Trust I-ORG Senior I-ORG Research I-ORG Fellowship I-ORG 212273/Z/18/Z O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O Nos O 81560271 B-AWARD and I-AWARD 81860296 O Key O Project O of O Scientific B-ORG Research I-ORG of I-ORG the I-ORG Guangxi I-ORG Colleges I-ORG and I-ORG Universities O No. O KY2015ZD092 B-AWARD and O the O Program O of O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangxi O No. O 2014GXNSFAA118253 B-AWARD and I-AWARD 2017GXNSFDA198005 I-AWARD This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81602346 O Applied B-ORG Basic I-ORG Research I-ORG Projects I-ORG of I-ORG Yunnan I-ORG Province I-ORG 2018FB137 O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG QYZDB-SSW-SMC020 O and I-AWARD KJZD-EW-L14 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O financial O support O from O national O funds O FCT/MCTES O Fundação I-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG Tecnologia I-ORG and I-ORG Ministério I-ORG da I-ORG Ciência I-ORG Tecnologia I-ORG e I-ORG Ensino I-ORG Superior O through O LAQV/REQUIMTE O UID/QUI/50006/2020 O CBIOS O UIDB/04567/2020 O UIDP/04567/2020 B-AWARD UMIB O UIDB/00215/2020 O UIDP/00215/2020 B-AWARD LA/P/0064/2020 B-AWARD ITR O LA/P/0064/2020 O Vera O M. O S. O Isca O SFRH/BD/137671/2018 O Marco O G. O Alves O 2021.03439.CEECIND O Also O this O work O was O financed O by O the O European B-ORG Regional I-ORG Development I-ORG Fund I-ORG ERDF O through O the O Centro O 2020 O Regional O Operational O Programme O under O project O CENTRO-01-0246-FEDER-000010 B-AWARD Multidisciplinary O Institute O of O Ageing O Coimbra O through O the O COMPETE B-ORG 2020—Operational I-ORG Programme I-ORG for I-ORG Competitiveness I-ORG and I-ORG Internationalisation I-ORG and I-ORG Portuguese I-ORG national I-ORG funds I-ORG via I-ORG FCT—Fundação I-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG a I-ORG Tecnologia O under O project[s O UIDB/04033/2020 B-AWARD and O UIDB/04539/2020 B-AWARD UIDP/04539/2020 B-AWARD and O LA/P/0058/2020 B-AWARD This O work O was O supported O by O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 O Program O grant O number O 2014CB541600 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 81501002 B-AWARD and O 81220108009 B-AWARD and O the O Basic B-ORG Science I-ORG and I-ORG Advanced I-ORG Technology I-ORG Research I-ORG Project I-ORG of I-ORG Chongqing I-ORG grant O number O cstc2016jcyjA1730 B-AWARD The O funders O were O not O involved O in O the O study O design O in O the O collection O analysis O and O interpretation O of O the O data O in O the O writing O of O the O report O and O in O the O decision O to O submit O the O article O for O publication O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 41877297 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities O China O University O of O Geosciences O Wuhan O CUGQY1950 O the O City B-ORG Geological I-ORG Survey I-ORG of I-ORG Guangzhou I-ORG DD20190219 O and O the O Environmental O Geological O Survey O in O Guangdong–Hong O Kong–Macao O Greater O Bay O Area O Grant O No. O 121201009000150101 O This O research O is O financially O supported O by O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Project O No. O 51575543 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG Project O No. O 2014A030313211 B-AWARD Guangdong-Hongkong O Technology O Cooperation O Funding O Scheme O 2016A050503027 O and O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG No. O 2015B010125004 B-AWARD S.D O was O supported O by O an O Australian B-ORG Research I-ORG Council I-ORG Discovery I-ORG Early I-ORG Career I-ORG Researcher I-ORG Award O DE190100805 O and O an O Australian B-ORG National I-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG APP1157586 O A.R O was O supported O by O the O Wellcome B-ORG Trust I-ORG Collaborators O Award O 206298/Z/17/Z―ARTIC B-AWARD network O P.L O acknowledges O funding O from O the O European O Research O Council O under O the O European O Union's O Horizon O 2020 O research O and O innovation O programme O 725422-ReservoirDOCS O and O the O Research O Foundation—Flanders O ‘Fonds O voor O Wetenschappelijk O Onderzoek—Vlaanderen’ O G066215N B-AWARD G0D5117N B-AWARD and O G0B9317N B-AWARD G.B O acknowledges O support O from O the O Interne O Fondsen O KU O Leuven/Internal O Funds O KU O Leuven O C14/18/094 O and O the O Research O Foundation—Flanders O ‘Fonds O voor O Wetenschappelijk O Onderzoek O – O Vlaanderen’ O G0E1420N B-AWARD This O work O was O supported O by O the O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG 2016-I2M-1-014 O 2017-I2M-2-006 B-AWARD the O Yunnan B-ORG Applied I-ORG Basic I-ORG Research I-ORG Projects I-ORG 2018FB113 O and O the O Yunnan B-ORG innovation I-ORG team I-ORG in I-ORG China I-ORG 2016HC009 O This O study O was O supported O by O Program B-ORG for I-ORG Innovation I-ORG Research I-ORG Team I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG IRT16R23 O Key B-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Project I-ORG of I-ORG Henan I-ORG Province I-ORG 151100110800 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31572356 O National O Natural O Science O Foundation O of O China O 31501948 O Research B-ORG on I-ORG the I-ORG Foundation I-ORG and I-ORG Frontier I-ORG Technology I-ORG of I-ORG Henan I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG 162300410162 O the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-40-K04 O The O funding O agencies O had O not O involved O in O the O experimental O design O analysis O and O interpretation O of O the O data O or O writing O of O the O manuscript O This O study O was O supported O by O Science B-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Qinghai I-ORG Province I-ORG 2021-ZJ-729 O Key B-ORG Laboratory I-ORG of I-ORG Medicinal I-ORG Animal I-ORG and I-ORG Plant I-ORG Resources I-ORG of I-ORG Qinghai-Tibetan I-ORG Plateau I-ORG in I-ORG Qinghai I-ORG Province I-ORG 2020-ZJ-Y04 O Agricultural B-ORG Resources I-ORG and I-ORG Environmental I-ORG Protection I-ORG Project I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Agriculture I-ORG and I-ORG Rural I-ORG Areas I-ORG 125C0505 O This O work O was O supported O by O grants O from O Scientific B-ORG and I-ORG technological I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81830111 B-AWARD the O Scientific B-ORG and I-ORG technological I-ORG innovation I-ORG project I-ORG of I-ORG the I-ORG China I-ORG Academy I-ORG of I-ORG Chinese I-ORG Medical I-ORG Sciences I-ORG No. O CI2021A04904 B-AWARD CI2021B015 B-AWARD CI2021A04907 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG public I-ORG Welfare I-ORG Research I-ORG Institutes I-ORG ZXKT17058 O ZZ13-YQ-095 B-AWARD and O the O Intergovernmental B-ORG Cooperation I-ORG in I-ORG International I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG No. O 2022YFE0119300 B-AWARD This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Nos O 2017YFA0304100 B-AWARD 2016YFA0302700 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 11774335 B-AWARD 11734015 I-AWARD 11804330 I-AWARD 11821404 O Key O Research O Program O of O Frontier O Sciences O CAS O No. O QYZDY-SSW-SLH003 O Science B-ORG Foundation I-ORG of I-ORG the I-ORG CAS I-ORG No. O ZDRW-XH-2019-1 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Nos O WK2470000026 B-AWARD WK2470000027 I-AWARD WK2470000028 O Anhui O Initiative O in O Quantum O Information O Technologies O Nos O AHY020100 O AHY070000 O This O study O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81271144 O Shanxi B-ORG “1331 I-ORG Project” I-ORG Key I-ORG Innovative I-ORG Research I-ORG Team I-ORG TD201809 O Youth B-ORG Fund I-ORG of I-ORG Shanxi I-ORG Applied I-ORG Basic I-ORG Research I-ORG 201801D221270 O Shanxi B-ORG Medical I-ORG University I-ORG School I-ORG and I-ORG Hospital I-ORG of I-ORG Stomatology I-ORG Fund I-ORG KY201803 O This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China O No. O 81772651 B-AWARD and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O No. O 2018A03031042 B-AWARD and O Guangzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Project O No. O 201804010138 B-AWARD and O the O Program B-ORG for I-ORG Changjiang I-ORG Scholars I-ORG and I-ORG Innovative I-ORG Research I-ORG Team I-ORG in I-ORG University O No. O IRT_16R37 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O A O scholarship O was O granted O to O Aaron O García O Rosales O Number O 266937 B-AWARD by O Consejo B-ORG Nacional I-ORG de I-ORG Ciencia I-ORG y I-ORG Tecnología I-ORG and O field O work O was O supported O by O the O projects O Comisión B-ORG Nacional I-ORG para I-ORG el I-ORG Conocimiento I-ORG y I-ORG Uso I-ORG de I-ORG la I-ORG Biodiversidad I-ORG JM001 B-AWARD and O Fondos B-ORG Mixtos-Consejo I-ORG Nacional I-ORG de I-ORG Ciencia I-ORG y I-ORG Tecnología-191908 O Biodiversidad O del O Estado O de O Hidalgo-3a O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O work O was O supported O by O the O Foundation O for O High-level B-ORG Talents I-ORG in I-ORG Higher I-ORG Education I-ORG of I-ORG Guangdong I-ORG No.C10454 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31371128 B-AWARD and O MOE O Tier O 1: O R-581-000-191-112 O RY O received O financial O support O from O the O National B-ORG University I-ORG of I-ORG Singapore I-ORG Grant I-ORG WBS B-AWARD R-581-000-166-133 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O authors O acknowledge O the O support O of O grants O from O the B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Hubei I-ORG Province I-ORG 2021BCA114 O the B-ORG Research I-ORG Fund I-ORG of I-ORG the I-ORG Health I-ORG Commission I-ORG of I-ORG Hubei I-ORG Province I-ORG WJ2021M255 O and O the B-ORG Cancer I-ORG Research I-ORG and I-ORG Translational I-ORG Platform I-ORG Project I-ORG of I-ORG Zhongnan I-ORG Hospital I-ORG of I-ORG Wuhan I-ORG University I-ORG ZLYNXM202004 O This O work O was O supported O by O Telethon B-ORG Italy I-ORG GUP13012 B-AWARD by O Association B-ORG Francaise I-ORG contre I-ORG les I-ORG Myopathies I-ORG AFM O grant O number O 16593 B-AWARD by O Regione B-ORG Emilia I-ORG Romagna I-ORG progetto O RARER B-AWARD We O are O greatly O thankful O to O Hanna O Lachert O and O the O Segal O family O for O their O generous O donation O supporting O our O research O This O work O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61435012 O 61505196 O the O National B-ORG 973 I-ORG program I-ORG 2014CB643903 O 2013CB933304 O the O Open B-ORG Fund I-ORG of I-ORG High I-ORG Power I-ORG Laser I-ORG Lab I-ORG China I-ORG Academy I-ORG of I-ORG Engineering I-ORG Physics I-ORG Grant O No. O 2013HEL03 B-AWARD and O Shanxi B-ORG Province I-ORG International I-ORG Science I-ORG and I-ORG Technology I-ORG Cooperation I-ORG and I-ORG Exchange I-ORG Project I-ORG 2016KW-040 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81630090 O to O Shibo O Jiang O 81672019 B-AWARD and O 8161101485 B-AWARD to O Lu O Lu O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC1201000 O and O 2016YFC1200405 B-AWARD to O Shibo O Jiang O 2016YFC1202901 B-AWARD to O Lu O Lu O and O the O National B-ORG Megaprojects I-ORG of I-ORG China I-ORG for I-ORG Major I-ORG Infectious I-ORG Diseases I-ORG 2018ZX10301403 O to O Lu O Lu O This O research O was O supported O by O the O Leiden B-ORG University I-ORG Fund/Mr O J.J O van O Walsem O Fonds O W18205-5-95 B-AWARD to O F.B O Netherlands B-ORG Science I-ORG Foundation I-ORG 016.VIDI.185.036 B-AWARD to O M.E.K O and O the O Talent O Grant O 406-15-026 B-AWARD from O Nederlandse B-ORG Organisatie I-ORG voor I-ORG Wetenschappelijk I-ORG Onderzoek I-ORG to O M.E.K O and O E.P O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0501200 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31872464 O and O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O The O sampling O works O were O supported O by O the B-ORG basic I-ORG scientific I-ORG research I-ORG special I-ORG project I-ORG in I-ORG Chinese I-ORG Academy I-ORG of I-ORG Fishery I-ORG Sciences I-ORG 2017HY-ZD0104 O the O experiment O works O were O supported O by O Nanjing B-ORG Agriculture I-ORG University I-ORG Program I-ORG for I-ORG Student I-ORG Innovation I-ORG through I-ORG Research I-ORG and I-ORG Training I-ORG Funding I-ORG 201710307038 O the O professional O language O editing O work O and O other O works O were O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG for I-ORG Young I-ORG Scientists I-ORG 31302169 O and O the B-ORG China I-ORG agriculture I-ORG research I-ORG system I-ORG CARS-46 O The O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81803463 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2018A030310183 O and O the O Natural O Science O Foundation O Project O of O Guangzhou B-ORG Medical I-ORG University I-ORG Grant O No. O 2016C29 B-AWARD This O study O was O supported O by O Key B-ORG laboratory I-ORG of I-ORG Karst I-ORG ecosystem I-ORG and I-ORG treatment I-ORG of I-ORG rocky I-ORG desertification I-ORG Ministry I-ORG of I-ORG Land I-ORG and I-ORG Resources I-ORG YR-JJHT-2017-758 O Special B-ORG Funds I-ORG for I-ORG Local I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Guided I-ORG by I-ORG the I-ORG Central I-ORG Committee I-ORG ZY1949013 O and O Guilin B-ORG Science I-ORG and I-ORG Technology I-ORG Foundation I-ORG 20180107-6 O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 61601104 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province O grant O number O F2017501052 B-AWARD and O the B-ORG Basic I-ORG Science I-ORG Research I-ORG Fund I-ORG of I-ORG Northeast I-ORG University I-ORG at I-ORG Qin I-ORG Huang I-ORG Dao O grant O number O XNB201611 B-AWARD This O trial O was O conducted O under O four O grants O funded O by O Guangzhou B-ORG Medical I-ORG Scientific I-ORG Research I-ORG Foundation I-ORG Agreement O No. O 201102A211001 B-AWARD and O 20121A011123 B-AWARD Guangzhou B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG Agreement O No. O 201607010332 B-AWARD 201707010184 B-AWARD and O the B-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG 2018ZX10715004 O The O funders O had O no O role O in O the O study O design O data O collection O data O analysis O data O interpretation O or O writing O of O the O manuscript O This O work O was O sponsored O by O the O National B-ORG Natural I-ORG Science I-ORG Funds I-ORG 71673187 O 71603166 O Shanghai B-ORG Pujiang I-ORG Program I-ORG 14PJC076 O Social B-ORG Cognitive I-ORG and I-ORG Behavioral I-ORG Sciences I-ORG program I-ORG of I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University(14JCRY03 O Cross-study B-ORG Reseach I-ORG Foundation I-ORG about I-ORG Medicine I-ORG and I-ORG Engineering I-ORG of I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG YG2014QN23 O The O funding O body O played O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O National B-ORG Science I-ORG Council I-ORG NSC O Taiwan O NSC O 101-2321-B-001-028-MY3 O National B-ORG Health I-ORG Research I-ORG Institutes O Taiwan O MR-108-GP-09 O MR-109-GP-09 B-AWARD to O R.-J.L O Ministry B-ORG of I-ORG Science I-ORG Technology I-ORG MOST-106-2320-MY2 O National O Health O Research O Institutes O Taiwan O 07A1-IVPP27 O to O C.-L.L O Ministry O of O Science O Technology O MOST-103-2321-B-016-006 O and O MOST-104-2321-B-016-002 B-AWARD Ministry B-ORG of I-ORG National I-ORG Defense-Medical I-ORG Affiairs I-ORG Bureau I-ORG MAB-106-110 O to O C.-H.H O Funding O for O open O access O charge O National O Health O Research O Institutes O Taiwan O to O R.-J.L O National B-ORG Institutes I-ORG of I-ORG Health I-ORG RO1HL058234 O R01HL113614 B-AWARD R01GM127823 B-AWARD to O M.N.G O 5T32AI052080 B-AWARD to O J.D.W O R35GM118077 B-AWARD to O S.J.R O R15CA182978 B-AWARD to O E.D.L O R01ES030084 B-AWARD to O A.P O Alabama B-ORG Commission I-ORG on I-ORG Higher I-ORG Education I-ORG 180435 O to O D.H O National B-ORG Science I-ORG Foundation I-ORG 1350064 O to O G.M.B O Funding O for O open O access O charge O National O Institutes O of O Health O HP O and O HB O received O funding O from O Swissgenetics B-ORG Zollikofen O Switzerland O https://swissgenetics.ch O Grant-ID O 13453 B-AWARD HP O received O funding O from O the O Förderverein B-ORG Biotechnologieforschung I-ORG e.V I-ORG FBF I-ORG Bonn I-ORG Germany I-ORG https://www.fbf-forschung.de O Grant-ID O 2‐70024‐18 B-AWARD HP O received O funding O from O the O Swiss B-ORG Federal I-ORG Office I-ORG for I-ORG Agriculture I-ORG Bern I-ORG https://www.blw.admin.ch/blw/de/home.html O Grant-ID O 927000958 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Major B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG for I-ORG Water I-ORG Pollution I-ORG Control I-ORG and I-ORG Treatment I-ORG 2017ZX07201002 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2019B14114 O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG 2016YFC0400800-04];Priority O Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81871899 B-AWARD 81802312 B-AWARD 81903038 B-AWARD Fujian B-ORG Health I-ORG Scientific I-ORG Research I-ORG Talent I-ORG Training I-ORG Program-medical I-ORG Innovation I-ORG from I-ORG Fujian I-ORG Provincial I-ORG Health I-ORG Commission I-ORG No. O 2019-CX-20 B-AWARD Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Joint I-ORG Fund I-ORG Project I-ORG of I-ORG Fujian I-ORG Province I-ORG No. O 2017Y9004 B-AWARD Fujian B-ORG Provincial I-ORG Health I-ORG Technology I-ORG Project I-ORG No. O 2019-ZQN-37 B-AWARD and O the O Youth B-ORG Research I-ORG Project I-ORG of I-ORG Fujian I-ORG Province I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG No. O 2018-1-40 B-AWARD The O study O was O jointly O founded O by O Talent B-ORG Project I-ORG of I-ORG Zhejiang I-ORG Association I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG 2018YCGC003 O Zhejiang B-ORG Province I-ORG Civil I-ORG Policy I-ORG Theory I-ORG Research I-ORG Plan I-ORG ZMYB201652 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG LQ15G030006 O and O Ministry B-ORG of I-ORG Education I-ORG of I-ORG China I-ORG Youth I-ORG Project I-ORG of I-ORG Humanities I-ORG and I-ORG Social I-ORG Sciences I-ORG 15YJC80024 O Funders O had O no O role O in O study O design O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O 31640068 B-AWARD the O Anhui B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O 1808085QC79 B-AWARD and O the O Graduate B-ORG innovation I-ORG fund I-ORG of I-ORG Anhui I-ORG Agricultural I-ORG University I-ORG Grant O 2018yjs-41 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O by O the O Economic B-ORG and I-ORG Social I-ORG Research I-ORG Council I-ORG ESRC O grant O ES/L007509/1 B-AWARD for O the O Administrative O Data O Research O Northern O Ireland O The O data O collection O from O the O Statistics O Finland O and O AV O and O AKos O were O supported O by O the O Academy B-ORG of I-ORG Finland I-ORG grant O 267172 B-AWARD DOR O and O AKou O were O also O supported O by O the O Medical B-ORG Research I-ORG Council I-ORG MRC O grant O MR/K023241/1 B-AWARD AKou O was O additionally O supported O by O the O Academy O of O Finland O grant O 312310 B-AWARD for O the O Centre O of O Excellence O for O Research O on O Ageing O and O Care O RG O 3 O Migration O Care O and O Ageing O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O nos O 41602010 B-AWARD 41772001 B-AWARD the O Estonian B-ORG Research I-ORG Council I-ORG grant O nos O MOBJD62 B-AWARD PUT611 B-AWARD and O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG grant O no. O XDB26000000 B-AWARD This O work O was O supported O by O This O work O was O supported O by O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG grant O funded O by O the O Korea O government O MSIP B-AWARD NRF-2015R1A3A2033826 O and O “Cooperative O Research I-AWARD Program I-AWARD for I-AWARD Agriculture I-AWARD Science I-AWARD and I-AWARD Technology I-AWARD Development I-AWARD Project I-AWARD No. I-AWARD PJ0131642018)” O Rural B-ORG Development I-ORG Administration O Republic O of O Korea O Also O this O work O was O supproted O by O the O Royal B-ORG Society I-ORG International I-ORG Professorships I-ORG No.IC160046 O and O Biotechnology B-ORG and I-ORG BiologicalSciences I-ORG Research I-ORG Council I-ORG BBSRC I-ORG Partnership I-ORG award I-ORG BB/M027481/1 O UK. O This O study O was O supported O by O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG China I-ORG 2017ZX10103011-003 O 2018ZX10102001 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31570163 O and O Guangzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG key I-ORG projects I-ORG 201803040004 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Funding O for O this O research O was O provided O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41771231 O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG China I-ORG 2015CB953801 O Postdoctoral B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 2015M570006 B-AWARD and O Visiting B-ORG Leverhulme I-ORG Professor I-ORG Program I-ORG Grant O No. O VP2-2013-035 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81703896 B-AWARD 81673776 B-AWARD the O Capital B-ORG Health I-ORG Research I-ORG and I-ORG Development I-ORG of I-ORG Special I-ORG grant O number O 2016-2-4062 B-AWARD Beijing B-ORG municipal I-ORG science I-ORG and I-ORG technology I-ORG commission I-ORG grant O number O Z171100001017209 B-AWARD and O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O number O 2017YFC0108102 B-AWARD This O study O was O supported O by O a O grant O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81573209 B-AWARD a O grant O from O Taishan B-ORG Scholar I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG grant O number O ts201511105 B-AWARD and O a O grant O from O Health B-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG Shandong I-ORG Province I-ORG grant O number O 2013WS0158 B-AWARD This O study O has O been O partially O funded O by O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III I-ORG through O the O projects O PIE15/00027 B-AWARD and O FIS B-AWARD PI19/00888 I-AWARD Co-funded O by O European O Regional O Development O Fund/European O Social O Fund O “A O way O to O make O Europe”/”Investing O in O your O future” O Generalitat B-ORG de I-ORG Catalunya I-ORG 2017-SGR675 O CERCA B-AWARD and O Jazz B-ORG Pharmaceuticals I-ORG IST-16-10355 O This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG Grant O No. O 2018YFB0803402 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 61702503 B-AWARD and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanxi I-ORG Province I-ORG Grant O No. O 201701D111002 B-AWARD and O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shanxi I-ORG Province I-ORG Grant O No. O 201903D121121 B-AWARD This O research O was O funded O by O Sichuan B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 2022NSFSC1758 O Science B-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Sichuan I-ORG Province I-ORG China I-ORG grant O numbers O 23ZDYF3100 B-AWARD 2020YFN0151 B-AWARD 2020JDRC0095 B-AWARD 2019JDRC120 B-AWARD Xihua B-ORG University I-ORG Talent I-ORG Introduction I-ORG Project I-ORG grant O number O Z211046 B-AWARD and O Chengdu B-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG Sichuan I-ORG Province I-ORG China I-ORG 2022-YF09-00018-SN O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 42174054 O the O Natural B-ORG Science I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG Shaanxi I-ORG 2022JZ-17 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG CHD I-ORG 300102260206 O 300102261104 B-AWARD and O 300102272104 B-AWARD the O Key B-ORG Laboratory I-ORG of I-ORG Geospace I-ORG Environment I-ORG and I-ORG Geodesy I-ORG Ministry I-ORG of I-ORG Education I-ORG Wuhan I-ORG University I-ORG 20-01-05 O the O Guangxi B-ORG Young I-ORG and I-ORG Middle-aged I-ORG Teachers’ I-ORG Basic I-ORG Scientific I-ORG Research I-ORG Ability I-ORG Improvement I-ORG Project I-ORG 2021KY0389 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangxi I-ORG 2021JJB150124 O This O research O was O funded O by O the O CIBERehd B-ORG EHD15PI05/2016 O and O “Fondo O de O Investigaciones O Sanitarias O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III” O Spain O PI16/00598 O and O PI19/00819 O co-funded O by O European O Regional O Development O Fund/European O Social O Fund O “Investing O in O your O future” O Spanish O Ministry O of O Economy O Industry O and O Competitiveness O SAF2016-75197-R O “Junta O de I-ORG Castilla I-ORG y I-ORG Leon” O SA063P17 O AECC B-ORG Scientific I-ORG Foundation I-ORG 2017/2020 O Spain O “Proyectos O de O Investigación O Modalidad O C2” O University O of O Salamanca O 18.K137/463AC01 O and O 18.K140/463AC01 O “Centro O Internacional O sobre O el O Envejecimiento” O OLD-HEPAMARKER O 0348_CIE_6_E O Spain O and O Fundación O University O of O Salamanca O Spain O PC-TCUE18-20_051 O L.P.-S O was O supported O by O a O predoctoral O contract O funded O by O the O Institute O of O Health O Carlos O III O Ministry O of O Economy O and O Competitiveness O Spain O FI17/00149 O A.P.-V O A.S.-M O C.C.-L O and O P.S.-S O were O supported O by O predoctoral O scholarships O FPU O funded O by O the O Ministry O of O Science O Innovation O and O Universities O Spain O B.S.B O and O E.L O were O supported O by O predoctoral O and O postdoctoral O contracts O respectively O by O University O of O Salamanca O Spain O This O research O was O sponsored O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Xinjiang I-ORG Uygur I-ORG Autonomous I-ORG Region I-ORG 2022D01E059 O the O Deanship B-ORG of I-ORG Scientific I-ORG Research I-ORG Vice I-ORG Presidency I-ORG for I-ORG Graduate I-ORG Studies I-ORG and I-ORG Scientific I-ORG Research I-ORG King I-ORG Faisal I-ORG University O Saudi O Arabia O GRANT2669 O the O Program B-ORG for I-ORG Innovative I-ORG Research I-ORG Team I-ORG in I-ORG Universities I-ORG of I-ORG Inner I-ORG Mongolia I-ORG Autonomous I-ORG Region I-ORG NMGIRT2320 O the O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2022C02034 O and O the O Collaborative B-ORG Innovation I-ORG Center I-ORG for I-ORG Modern I-ORG Crop I-ORG Production I-ORG co-sponsored I-ORG by I-ORG Province I-ORG and I-ORG Ministry I-ORG CIC-MCP O This O work O was O carried O out O under O the O Project O Inpactus—innovative O products O and O technologies O from O eucalyptus O Project O Nº O 21874 O funded O by O Portugal B-ORG 2020 I-ORG through I-ORG the I-ORG European I-ORG Regional I-ORG Development I-ORG Fund I-ORG ERDF O in O the O frame O of O COMPETE O 2020 O nº246/AXIS B-AWARD II/2017 O This O work O was O also O developed O within O the O scope O of O the O project O CICECO-Aveiro B-ORG Institute I-ORG of I-ORG Materials O UIDB/50011/2020 B-AWARD UIDP/50011/2020 B-AWARD and O LA/P/0006/2020 B-AWARD financed O by O national B-ORG funds I-ORG through O the O FCT/MCTES O PIDDAC O The O research O contract O of O R.J.B O Pinto O was O funded O by O national O funds O OE O through O FCT O in O the O scope O of O the O framework O contract O foreseen O in O the O numbers O 4, O 5, O and O 6 O of O the O article O 23, O of O the O Decree-Law O 57/2016 B-AWARD of O August O 29, O changed O by O Law O 57/2017 B-AWARD of O July O 19. O FCT O is O also O acknowledged O for O the O research O contract O under O Scientific B-ORG Employment I-ORG Stimulus I-ORG to I-ORG C.S.R.F I-ORG CEECIND/00464/2017 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC I-ORG No. O 81471089 B-AWARD Shanghai B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG 2013ZYJB0801 O and O Shanghai B-ORG Key I-ORG Laboratory I-ORG of I-ORG Clinical I-ORG Geriatric I-ORG Medicine I-ORG 13dz2260700 O This O study O was O supported O by O grants O from O The O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81572787 O 81672683 I-AWARD 81672993 I-AWARD 81672688 I-AWARD 81702907 I-AWARD 81772901 I-AWARD 81772928 I-AWARD 81803025 I-AWARD and I-AWARD 81872278 O the O Overseas B-ORG Expertise I-ORG Introduction I-ORG Project I-ORG for I-ORG Discipline I-ORG Innovation I-ORG 111 O Project I-AWARD No. I-AWARD 111–2-12 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG 2016JC2035 O 2017SK2105 I-AWARD 2018JJ3704 I-AWARD 2018JJ3815 I-AWARD 2018SK21210 I-AWARD and I-AWARD 2018SK21211 O This O work O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No O 81873126 B-AWARD 81373774 B-AWARD Anhui B-ORG Medical I-ORG University I-ORG Foundation I-ORG for I-ORG Middle-aged I-ORG and I-ORG Young I-ORG Scientist I-ORG Leaders I-ORG of I-ORG Disciplines I-ORG in I-ORG Science I-ORG No. O 201324 B-AWARD and O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Projects I-ORG for I-ORG Major I-ORG New I-ORG Drugs I-ORG Innovation I-ORG and I-ORG Development I-ORG No. O 2017ZX09301012 B-AWARD This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81170570 O G.J.Y O 81370683 O G.J.Y O 81501251 O Y.J O 31571189 B-AWARD H.X.S O and O 81571402 B-AWARD G.J.Y O clinical B-ORG medicine I-ORG science I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BL2014003 O H.X.S O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG SBK2015042000 O Y.J O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 021414380104 O Y.J O This O work O was O supported O by O Grants O from O the B-ORG National I-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2012AA092104 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31570032 O O 31171201 B-AWARD and O the B-ORG NSFC-Shandong I-ORG Joint I-ORG Fund I-ORG for I-ORG Marine I-ORG Science I-ORG Research I-ORG Centers I-ORG U1406402 O This O work O was O supported O by O the O International B-ORG Cooperation I-ORG Project I-ORG of I-ORG China I-ORG and I-ORG Canada I-ORG NSFC I-ORG 81661128010 O The O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFC1001303 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31471405 O and O Medical B-ORG Crossover I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG YG2015MS42 O The O funding O agencies O had O no O role O in O study O design O data O collection O and O analysis O and O decision O to O submit O the O article O for O publication O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2015BAD16B04 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31470213 O 31670093 B-AWARD 81671842 B-AWARD Project B-ORG of I-ORG Tianjin I-ORG China I-ORG 14ZCZDSF00009 O 15ZCZDNC00450 B-AWARD 16JCZDJC37600 B-AWARD the B-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Medicinal I-ORG Chemical I-ORG Biology I-ORG 201603007 O and O the B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 2016M602796 O This O research O was O jointly O supported O by O Medical O Science O and O technology O development O Foundation O Nanjing B-ORG Medical I-ORG University I-ORG CN) O 2015NJMU064 O 2017NJMU055 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG CN) O 81670155 O 81602913 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG CN) O BK20150085 O Jiangsu B-ORG Provincial I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG CN) O Z201611 O and O Medical B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Foundation I-ORG Nanjing I-ORG Municipality I-ORG Health I-ORG Bureau I-ORG CN) O QRX17164 O YKK15140 B-AWARD M.A.K O K.M.R O and O D.S O are O funded O through O a O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG Professorship I-ORG for O M.A.K O NIHR-RP-2016-07-019 O M.A.K O is O also O funded O by O Rosetrees B-ORG Trust I-ORG CF2\100018 O the O Sir B-ORG Jules I-ORG Thorn I-ORG Trust I-ORG JTA-017 O and O the O MRC B-ORG MR/S036784/1 O M.Z O receives O research O support O from O the O German B-ORG Research I-ORG Foundation I-ORG DFG O 458949627 O ZE B-AWARD 1213/2-1 O This O study O was O supported O by O Jiangxi B-ORG Province I-ORG high-level I-ORG and I-ORG high-skill I-ORG leading I-ORG personnel I-ORG training I-ORG project O No. O 12623001 B-AWARD National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG for I-ORG the I-ORG Modernization I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG 2017YFC1702904 O Jiangxi B-ORG university I-ORG of I-ORG traditional I-ORG Chinese I-ORG medicine I-ORG 1050 I-ORG youth I-ORG talent I-ORG project O No. O 5142001007 B-AWARD and O Jiangxi B-ORG University I-ORG of I-ORG Chinese I-ORG Medicine I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Team I-ORG Development I-ORG Program I-ORG No. O CXTD-22004 B-AWARD This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31871532 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0300102 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2662017JC002 O This O study O was O funded O by O the O Science B-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG Breeding I-ORG of I-ORG New I-ORG Agricultural I-ORG Varieties I-ORG of I-ORG Zhejiang I-ORG 2021C02065 O the O Cooperative B-ORG Project I-ORG for I-ORG Breeding I-ORG of I-ORG New I-ORG Agricultural I-ORG Varieties I-ORG of I-ORG Wenzhou I-ORG 2019ZX007 O and O the O Doctoral B-ORG Research I-ORG Project I-ORG of I-ORG Wenzhou I-ORG Science I-ORG and I-ORG Technology I-ORG Vocational I-ORG College I-ORG 20183001 O This O work O was O supported O by O Grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31500686 O and O 31100609 B-AWARD the O Hunan B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 2017JJ3358 O and O the O National B-ORG University I-ORG of I-ORG Defense I-ORG Technology I-ORG Project I-ORG ZK17-03-58 O and O ZK16-03-13 B-AWARD This O work O was O financially O supported O by O Funds O of O Shandong B-ORG Province I-ORG Modern I-ORG Agricultural I-ORG Industry I-ORG Technology I-ORG System I-ORG Bee I-ORG Industry I-ORG Innovation I-ORG Team I-ORG Breeding I-ORG and I-ORG Resource I-ORG Protection I-ORG Post I-ORG Expert I-ORG Project I-ORG No. O SDAIT-24-02 B-AWARD Shandong B-ORG Province I-ORG Agricultural I-ORG Variety I-ORG Project I-ORG No. O 2016LZGC039 O Shandong B-ORG “Double I-ORG Tops” I-ORG Program I-ORG No. O SYL2017YSTD12 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 52272034 B-AWARD the O Natural B-ORG Science I-ORG Basic I-ORG Research I-ORG Plan I-ORG of I-ORG Shaanxi I-ORG Province I-ORG of I-ORG China I-ORG grant O no. O 2020JQ-726 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Sichuan I-ORG Province I-ORG project O no. O 2022NSFSC0327 B-AWARD and O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shaanxi I-ORG Province I-ORG no. O 2021GY-252 B-AWARD no. O 2022GY-367 B-AWARD The O funding O body O and O sponsors O had O no O role O in O study O design O data O collection O data O analysis O data O interpretation O and O in O writing O the O manuscript O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81670940 B-AWARD 81670941 B-AWARD 81570933 B-AWARD and O 81400472 B-AWARD and O Special B-ORG Cultivating I-ORG and I-ORG Developing I-ORG Program I-ORG of I-ORG Beijing I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Base I-ORG z151100001615050 O Youth B-ORG cultivation I-ORG project I-ORG of I-ORG military I-ORG medical I-ORG science I-ORG 16QNP133 O the B-ORG major I-ORG project I-ORG of I-ORG Twelfth I-ORG Five-Year I-ORG Plan I-ORG BWS14J045 O This O work O was O financially O supported O by O Thousand O Talents O Program O ODCCC2268 O Yin-xiong O Li O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 973 I-ORG Program I-ORG 2015CB964700 O and O the O Guangdong B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG 2014B020225004 O 2015B020230007 O 2016B030301007 B-AWARD Haizhu B-ORG District I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG 2011-ZD-02 O 2014-CG-05 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O Guizhou B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Foundation I-ORG Qianke O Joint I-AWARD Foundation I-AWARD ZK I-AWARD 2023 I-AWARD General I-AWARD 264 O Qianke B-AWARD Joint I-AWARD Foundation I-AWARD ZK I-AWARD 2023 I-AWARD General I-AWARD 265 O the O Guizhou B-ORG Science I-ORG and I-ORG Technology I-ORG support I-ORG Plan I-ORG Project I-ORG Qianke O Joint I-AWARD Support I-AWARD 2021 I-AWARD General I-AWARD 486 O the O Special B-ORG Project I-ORG of I-ORG Scientific I-ORG Research I-ORG on I-ORG the I-ORG Introduction I-ORG of I-ORG Talents I-ORG in I-ORG Huzhou I-ORG Vocational I-ORG and I-ORG Technical I-ORG College I-ORG No. O 2022GY04 O Guizhou B-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG and I-ORG the I-ORG General I-ORG Undergraduate I-ORG University I-ORG Scientific I-ORG Research I-ORG Project I-ORG Youth O Project I-AWARD Qian I-AWARD Jiaoji I-AWARD 2022 I-AWARD 128 O The O authors O are O extremely O grateful O for O the O support O of O school O of O materials O and O architectural O engineering O from O Guizhou O Normal O University O This O study O was O funded O by O Taipei B-ORG Medical I-ORG University I-ORG and O the O Taipei O Medical O University O Hospital O under O a O joint O research O grant O 109TMU-TMUH-11 O This O study O was O also O partially O funded O by O the O European B-ORG Union’s I-ORG Horizon I-ORG H2020 I-ORG iHelp I-ORG project I-ORG under O the O research O grant O GA: O 101017441 B-AWARD and O MOST O Taiwan B-ORG 110-2923-E038-001-MY3 B-AWARD and O the O European B-ORG Union’s I-ORG Horizon I-ORG H2020 I-ORG LifeChamps I-ORG under O the O research O grant O GA: O 875329 B-AWARD This O work O was O supported O by O following O projects O The B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 81603039 B-AWARD the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG grant O numbers O H2019209254 B-AWARD North O China O University B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Foundation I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG grant O numbers O JQ201713 B-AWARD and O Distinguished O Young O Scholars O of O Hebei O Province O This O work O was O supported O by O a O National B-ORG Institute I-ORG of I-ORG Environmental I-ORG Health I-ORG Sciences I-ORG http://www.niehs.nih.gov O ES00267 B-AWARD to O TVH O and O CS, O National B-ORG Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases I-ORG https://www.niaid.nih.gov O K24 B-AWARD 77930 I-AWARD to O TVH O National B-ORG Institutes I-ORG of I-ORG Health I-ORG http://www.nih.gov O ES15855 B-AWARD to O TVH O and O R01 O HS O 018454 O to O TVH O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O measurements O were O funded O by O the O Polish B-ORG Ministry I-ORG of I-ORG Science I-ORG under O project O No. O 752/1/N-COST-2 B-AWARD 010-0 I-AWARD “Assessment O of O the O temporal O and O spatial O variation O of O the O biophysical O and O spectral O indices O NDVI O PRI O WBI O in O reference O to O net O exchange O of O CO2 O CH4 O H2O O between O different O ecosystems O peatland O forest O and O arable O and O the O atmosphere” O During O data O processing O and O manuscript O writing O Radosław O Juszczak O was O supported O by O project O No. O 2016/21/B/ST10/02271 B-AWARD funded O by O the O National B-ORG Science I-ORG Centre I-ORG of I-ORG Poland O This O project O has O received O funding O also O from O the O European B-ORG Union’s I-ORG Horizon I-ORG 2020 I-ORG research I-ORG and I-ORG innovation I-ORG programme I-ORG under I-ORG the I-ORG Marie I-ORG Skłodowska-Curie I-ORG Grant I-ORG Agreement I-ORG No. O 749323 B-AWARD There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC1102603 O 2016YFC1102605 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51672122 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2015A030313299 O 2016A030313673 B-AWARD This O work O was O supported O by O The O Netherlands O Organisation O for O Health O Research O and O Development O ZonMw O project O number O 171002202,https://www.zonmw.nl/nl/onderzoek-resultaten/doelmatigheidsonderzoek/programmas/project-detail/doelmatigheidsonderzoek/physical-activity-during-cancer-treatment-pact-studie-een-gerandomiseerde-studie-naar-de-effecten B-AWARD PHMP O the O Dutch O Cancer O Society O KWF O Kankerbestrijding O Project O number O UU B-AWARD 2009-4473 O PHMP O the O Dutch B-ORG Pink I-ORG Ribbon I-ORG Foundation I-ORG 2011.WO02.C100,https://www.pinkribbon.nl/doelbestedingen/wetenschappelijk-onderzoek/2011/pact-studie.html O AMM O and O VIOZ O Stichting O Vrienden I-ORG Integrale I-ORG Oncologische I-ORG Zorg I-ORG 2015 O MJV O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National O Institutes O of O Health O National O Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases I-ORG 1R01AI114310 B-AWARD UNC-South O China O STD O Research O Training O Centre O Fogarty O International I-ORG Centre I-ORG 1D43TW009532 B-AWARD to O JT O UNC O Center O for O AIDS O Research O National O Institute O of O Allergy O and O Infectious O Diseases O 5P30AI050410 B-AWARD the O UNC O Chapel O Hill O Johns O Hopkins O University O Morehead O School O of O Medicine O and O Tulane O University O UJMT O Fogarty O Fellowship O FIC O R25TW0093 B-AWARD and O American O Psychological O Association’s O Cyber O Mentors O Program O National O Institute I-ORG of I-ORG Mental I-ORG Health I-ORG R25-MH083635 B-AWARD The O listed O grant O funders O played O no O role O in O any O step O of O this O study O This O research O was O supported O by O grants O from O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG Grant O funded O by O the O Korean O Government O NRF-2018R1A2B6002396 O the O Ministry B-ORG of I-ORG Food I-ORG and I-ORG Drug I-ORG Safety I-ORG 16162MFDS029 O and O the O Korea B-ORG Centers I-ORG for I-ORG Disease I-ORG Control I-ORG and I-ORG Prevention I-ORG 2017-NI41003 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 31572266 B-AWARD and O 31672551 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0500302 O the O National B-ORG Sharing I-ORG Service I-ORG Platform I-ORG for I-ORG Parasite I-ORG Resources I-ORG No. O TDRC-22 B-AWARD and O Shanghai O Minhang O District O talent O development O special O funds O This O work O was O supported O by O the O Guangzhou B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG No. O 201803010046 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81672232 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2015B020233013 B-AWARD This O work O was O supported O by O the O Special B-ORG Fund I-ORG for I-ORG Health I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG Grant O Number O 201502001 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Number O 81672819 B-AWARD and O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Grant O Number O 2018YFC1313100 B-AWARD The O funding O source O of O the O study O had O no O role O in O study O design O data O collection O analysis O interpretation O or O writing O the O report O The O first O author O and O corresponding O authors O had O full O access O to O all O the O study O data O and O final O responsibility O for O submission O for O publication O This O work O was O supported O by O grants O from O the O Medical B-ORG Research I-ORG Council I-ORG and O Economic O O Social O Research O Council O grant O no. O G1001375/1 B-AWARD the O National B-ORG Institute I-ORG of I-ORG Health I-ORG Research I-ORG grant O no. O ES/L001772/1 B-AWARD and O the O European B-ORG Union’s I-ORG Horizon I-ORG 2020 I-ORG Research I-ORG and I-ORG Innovation I-ORG Programme I-ORG grant O no. O 668648 B-AWARD to O Gindo O Tampubolon O Asri O Maharani O was O supported O by O SENSE-Cog O project O European O Union’s O Horizon O 2020 O research O and O innovation O programme O under O grant O agreement O No O 668648 O This O work O was O supported O by O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2016M602548 O Specialized B-ORG Research I-ORG Fund I-ORG for I-ORG the I-ORG Doctoral I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG 20124425110010 O The B-ORG Special I-ORG Funds I-ORG from I-ORG Central I-ORG Finance I-ORG of I-ORG China I-ORG in I-ORG Support I-ORG of I-ORG the I-ORG Development I-ORG of I-ORG Local I-ORG Colleges I-ORG and I-ORG University I-ORG 276 O 2014 O This O research O was O supported O by O the O MHLW B-ORG Research I-ORG on I-ORG Risk I-ORG of I-ORG Chemical I-ORG Substances I-ORG Program I-ORG Grant O Number O 21KD1002 B-AWARD grants O from O the O Tamura B-ORG Science I-ORG and I-ORG Technology I-ORG Foundation I-ORG Toyama I-ORG Prefecture I-ORG Medical I-ORG Association O NIH B-AWARD 1P20GM121298 O and O 3P20GM121298 B-AWARD grants O JST B-ORG Moonshot I-ORG R&D I-ORG Grant O Number O JPMJMS2021 B-AWARD and O JSPS B-ORG KAKENHI I-ORG Grant O Numbers O JP20K09614 B-AWARD and O JP22H03223 B-AWARD Data O collections O for O this O study O were O conducted O by O the B-ORG Nutrition I-ORG Institute I-ORG Ljubljana O Slovenia O within O the O national O research O programme O “Nutrition O and O Public O Health” O P3-0395 O and O “Infrastructure O programme O for O monitoring O of O the O composition O and O labelling O of O foods” O IO-0054)—funded O by O the B-ORG Slovenian I-ORG Research I-ORG Agency O and O within O the O Food O Nutrition O Security O Cloud O project O FNS-Cloud O which O has O received O funding O from O the B-ORG European I-ORG Union’s I-ORG Horizon I-ORG 2020 I-ORG Research I-ORG and I-ORG Innovation I-ORG programme I-ORG H2020-EU.3.2.2.3.—A O sustainable O and O competitive O agri-food O industry O under O Grant O Agreement O No. O 863059 B-AWARD Information O and O views O in O this O report O do O not O necessarily O reflect O the O official O opinion O or O position O of O the O European O Union O Neither O European O Union O institutions O and O bodies O nor O any O person O acting O on O their O behalf O may O be O held O responsible O for O the O use O that O may O be O made O of O the O information O contained O herein O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41571122 O the O Natural B-ORG Science I-ORG Foundation I-ORG Guidance I-ORG Program I-ORG of I-ORG Liaoning I-ORG Province I-ORG 20180551194 O the O Education B-ORG Commission I-ORG of I-ORG Liaoning I-ORG Province I-ORG of I-ORG China I-ORG H201783631 O WQ2019020 B-AWARD the O Social B-ORG Science I-ORG Federation I-ORG 2019 I-ORG Economic I-ORG and I-ORG Social I-ORG Development I-ORG of I-ORG Liaoning I-ORG Province I-ORG 2019lslktjd-014 O the O Liaoning B-ORG Planning I-ORG Fund I-ORG Project I-ORG of I-ORG Philosophy I-ORG and I-ORG Social I-ORG Science I-ORG L17CJY003 O and O the O PhD B-ORG Research I-ORG Startup I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Normal I-ORG University I-ORG BS2018L007 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Jiangsu B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG BK20141136 O to O Zhou O and O BK20151168 B-AWARD to O Liu O Jiangsu B-ORG Key I-ORG Laboratory I-ORG of I-ORG Brain I-ORG Disease I-ORG Bioinformation I-ORG to O Zhou O jsbl1205 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81500914 O to O Xue O 81372598 B-AWARD and O 81772688 B-AWARD to O Gao O and O 81700794 B-AWARD to O Hu O Dean O Special O Foundation O of O Xuzhou O Medical O University O 2012KJZ09 O to O Xue O the O Graduate B-ORG Innovation I-ORG Program I-ORG in I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Jiangsu I-ORG Province I-ORG KYLX18_2169 O to O Cao O and O the B-ORG Priority I-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG 2014 O PAPD O This O work O was O supported O in O part O by O special O zones O for O National O Defense O Science O and O Technology O innovation O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O 61673208 B-AWARD Grant O 61533008 B-AWARD Grant O 61533009 B-AWARD and O Grant O 61703208 B-AWARD in O part O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG under O Grant O BK20181291 B-AWARD Grant O BK20170815 B-AWARD and O Grant O BK20170767 B-AWARD and O in O part O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG under O Grant O NP2018108 B-AWARD and O Grant O NZ2019007 B-AWARD This O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31661143045 O and O 31972270 O the O International B-ORG Atomic I-ORG Energy I-ORG Agency I-ORG CRP O No. I-AWARD 18269 O Special B-ORG Fund I-ORG for I-ORG Agro-scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG 201503137 O the O National O Key O R O O D O Program O of O China O 2017YFD0200900 O and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG CN) O 2662015PY148 O to O CYN O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O a O grant O from O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG of I-ORG China I-ORG C2016050 O The B-ORG national I-ORG key I-ORG research I-ORG and I-ORG development I-ORG program I-ORG of I-ORG China I-ORG 2016YFD030010404 O Heilongjiang B-ORG Postdoctoral I-ORG Financial I-ORG Assistance I-ORG LBH-Q15133 O the O doctoral B-ORG Fund I-ORG of I-ORG Heilongjiang I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG 201507-05 O and O the O special O fund O for O China O Agricultural O Research O System O CARS-01-43 O This O work O has O been O supported O through O the O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health I-ORG award O number O R21MH115772-01 B-AWARD National B-ORG Institute I-ORG of I-ORG Diabetes I-ORG and I-ORG Digestive I-ORG and I-ORG Kidney I-ORG Diseases I-ORG award O numbers O 5R01DK109913 B-AWARD 2P30DK092949 B-AWARD and O P30DK092950 B-AWARD National B-ORG Cancer I-ORG Institute I-ORG award O number O R01CA214530 B-AWARD This O work O was O supported O by O National B-ORG Institute I-ORG of I-ORG Biomedical I-ORG Imaging I-ORG and I-ORG Bioengineering I-ORG R01 B-AWARD EB004759 O DT,https://www.nibib.nih.gov O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O 11672001 B-AWARD DT,https://isisn.nsfc.gov.cn/egrantweb O and O Jiangsu B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Agency I-ORG grant O BE2016785 B-AWARD DT,http://www.jstd.gov.cn O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31772566 O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Province I-ORG 1708085MC61 O the B-ORG Key I-ORG Research I-ORG Projects I-ORG of I-ORG Natural I-ORG Science I-ORG in I-ORG Anhui I-ORG Colleges I-ORG and I-ORG Universities I-ORG KJ2017A334 O and O the B-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG of I-ORG China I-ORG ASTIP-IAS13 O This O research O was O supported O by O Scientific B-ORG Research I-ORG Foundation I-ORG of I-ORG Education I-ORG Office I-ORG of I-ORG Hunan I-ORG Province I-ORG China I-ORG No.17A096 O ZY O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61701177 B-AWARD YC O Hunan B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China(2018JJ3225 O YC O Science B-ORG foundation I-ORG open I-ORG project I-ORG of I-ORG Hunan I-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Crop I-ORG Germplasm I-ORG Innovation I-ORG and I-ORG Utilization(18KFXM08 O YC O This O work O was O supported O by O National B-ORG Institutes I-ORG of I-ORG Health I-ORG GM098520 O National B-ORG Science I-ORG Foundation I-ORG BES-0828630 O and O Duke B-ORG University I-ORG Pharmacological I-ORG Sciences I-ORG Training I-ORG Program I-ORG PSTP I-ORG T32 O GM I-AWARD 007105 O This O research O was O funded O by O the O American B-ORG Optometric I-ORG Foundation I-ORG Beta B-AWARD Sigma I-AWARD Kappa I-AWARD Research I-AWARD Fellowship I-AWARD with O additional O support O by O the O National B-ORG Eye I-ORG Institute I-ORG under O P30 O EY003039 B-AWARD and O the O Office O of O Research O Infrastructure O Programs O of O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG under O S10 O RR027822-01 B-AWARD Our O laboratory O is O supported O byMRC(G00900901),BBSRC(BB/I021833/1 O andThe O Wellcome I-ORG Trust(092071/Z/10/Z O Funding O to O pay O the O Open O Access O publication O charges O for O this O article O was O provided O by O RCUK O Open O Access O Block O Grant O for O University O of O Oxford O This O paper O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 71503059 B-AWARD 71673022 B-AWARD 71420107023 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Nos O FRF-TP-16-050A1 B-AWARD FRF-BR-17-005B B-AWARD DUT17RC(4)24 B-AWARD Dalian B-ORG Social I-ORG Science I-ORG Foundation I-ORG No. O 2016dlskyb004 B-AWARD Beijing B-ORG Social I-ORG Science I-ORG Foundation I-ORG No. O 17LJB004 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 3187131067 O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG ASTIP-2016-IAS-06 O and I-AWARD CAAS-XTCX2016010 O and O the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-36 O This O work O was O supported O by O China B-ORG Medical I-ORG University I-ORG Hospital I-ORG in O Taiwan O DMR-99-015 O DMR-100-013 I-AWARD and I-AWARD DMR-102-013 O Taiwan B-ORG Ministry I-ORG of I-ORG Health I-ORG and I-ORG Welfare I-ORG Clinical I-ORG Trial I-ORG and I-ORG Research I-ORG Center I-ORG of I-ORG Excellence I-ORG MOHW105-TDU-B-212-133019 O and O National B-ORG Science I-ORG Council I-ORG in I-ORG Taiwan I-ORG NSC99-2314-B-039-005-MY3 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81573544 B-AWARD 81803669 I-AWARD and I-AWARD 81703654 O the O Department B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Sichuan I-ORG Province I-ORG No. O 2014SZ0156 B-AWARD and O Chengdu B-ORG University I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG Nos O ZRYY1610 B-AWARD and I-AWARD ZRQN1647 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81772651 B-AWARD and O 81772652 B-AWARD Projects B-ORG of I-ORG Public I-ORG Welfare I-ORG Research I-ORG and I-ORG Capacity I-ORG Development I-ORG of I-ORG Guangdong I-ORG Province I-ORG China O 2014A020212171 O and O The B-ORG Guangdong I-ORG Provincial I-ORG Clinical I-ORG Medical I-ORG Centre I-ORG for I-ORG Neurosurgery I-ORG No. O 2013B020400005 B-AWARD This O work O was O supported O by O grants O from O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG of I-ORG China I-ORG 2019J01380 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31902088 O the O Natural B-ORG Science I-ORG Foundation I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholar I-ORG of I-ORG Fujian I-ORG Agriculture I-ORG and I-ORG Forestry I-ORG University I-ORG of I-ORG China I-ORG xjq201919 O the O Excellent B-ORG Master I-ORG Thesis I-ORG Cultivation I-ORG Fund I-ORG of I-ORG Fujian I-ORG Agriculture I-ORG and I-ORG Forestry I-ORG University I-ORG Yayong O Yang O 1122YS01011 B-AWARD the O National B-ORG College I-ORG students I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Plan I-ORG Training I-ORG Project I-ORG Zhuohan O Jing O 202210389031 B-AWARD the O College B-ORG Students I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Plan I-ORG Training I-ORG Project I-ORG of I-ORG Fujian I-ORG Agriculture I-ORG and I-ORG Forestry I-ORG University I-ORG Xiaoyu O Li: O 202210389213 B-AWARD the O Seed B-ORG Industry I-ORG Innovation I-ORG and I-ORG Industrialization I-ORG Project I-ORG of I-ORG Fujian I-ORG Province I-ORG of I-ORG China I-ORG zycxny2021012 O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Planning I-ORG Project I-ORG of I-ORG Hebei I-ORG Province I-ORG 21326315D O and O the O HAAFS B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Special I-ORG Project I-ORG 2022KJCXZX-JZS-9 O This O study O was O partially O funded O by O FAPESP O O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo I-ORG grant O 2011/19128-1 O http://www.fapesp.br O The O author O BSK O received O a O scholarship O grant O by O CNPq O O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG O Brasil O grant O 240720/2013-0 O http://www.cnpq.br O The O author O JJL O receives O salary O support O from O the O UK B-ORG Medical I-ORG Research I-ORG Council I-ORG MR/K012126/1 O http://www.mrc.ac.uk O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Jun O Liu O was O supported O by O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Grants O No. O XDB26000000 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 41572019 B-AWARD State B-ORG Key I-ORG laboratory I-ORG of I-ORG Palaeobiology I-ORG and I-ORG stratigraphy I-ORG grants O No. O 20161101 B-AWARD China-South B-ORG African I-ORG Research I-ORG Project I-ORG CS08-L02 O Fernando O Abdala’s O research O was O supported O by O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG South I-ORG Africa I-ORG Conicet I-ORG from I-ORG Argentina I-ORG Agencia I-ORG Nacional I-ORG de I-ORG Promoción I-ORG Científica I-ORG y I-ORG Tecnológica I-ORG Argentina I-ORG PICT O 2015-2389 I-AWARD to I-AWARD N. I-AWARD Giannini O and O a O research O trip O to O China O funded O by O the O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG President’s I-ORG International I-ORG Fellowship I-ORG Initiative I-ORG Grant I-ORG 2016VBB054 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31572489 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Henan I-ORG 182300410078 O Henan B-ORG Science I-ORG and I-ORG Technology I-ORG Key I-ORG Project I-ORG 182102110061 O The O funding O entities O had O no O role O in O design O of O the O study O collection O analysis O or O interpretation O of O data O or O writing O of O the O manuscript O This O work O was O financially O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFA0506000 O National B-ORG Natural I-ORG Science I-ORG Funding I-ORG of I-ORG China I-ORG 81622043 O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG LR16H310001 O LY18H160047 B-AWARD and O LY17H160055 B-AWARD Medical B-ORG Scientific I-ORG Research I-ORG Fund I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2019322308 O and O Wenzhou B-ORG science I-ORG and I-ORG technology I-ORG project I-ORG Y20170280 O This O study O was O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2016YFC1303903 O and I-AWARD 2016YFC0901101 O Key B-ORG Program I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 91543207 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG HUST I-ORG 2016YXZD044 O and I-AWARD 2016JCTD116 O This O study O was O supported O by O funding O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 31772766 B-AWARD and O 31802203 B-AWARD the O 13th B-ORG Five-Year I-ORG Plan I-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2016YFD0500705 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG Southwest I-ORG Minzu I-ORG University I-ORG Grant O No. O 2017NZYQN01 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Joint I-ORG Fund I-ORG Key I-ORG Project I-ORG Grant O No. O U1865206 B-AWARD National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG Grant O No. O J2019-VIII B-AWARD 0003-0164 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2022M710415 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 12205016 B-AWARD and O Fundamentals B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 2021NTST14 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 31472127 B-AWARD received O by O HL;http://www.nsfc.gov.cn O and O the O National B-ORG High-Tech I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 863 O Program O grant O no.2013AA102803 O received O by O BY;http://program.most.gov.cn O and O the O National O Science O Fund O for O Distinguished O Young O Scholars O of O China O grant O no. O 31225026 O received O by O BY;http://www.nsfc.gov.cn O and O the O China B-ORG Modern I-ORG Agriculture I-ORG Research I-ORG System I-ORG grant O no. O CARS-42 B-AWARD received O by O BY;http://www.caas.net.cn/zytj/kjpt/xdnycyjztx/index.html O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 2019NY-085 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31470535 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Nos O 2017YFC1309100 B-AWARD and I-AWARD 2017YFA0205200 O and O the O Natural B-ORG Science I-ORG Basic I-ORG Research I-ORG Plan I-ORG in I-ORG Shaanxi I-ORG Province I-ORG of I-ORG China I-ORG No. O 2018JM2041 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Non-Profit I-ORG Industry-Funded I-ORG Research I-ORG and I-ORG Special I-ORG Projects I-ORG 201303016 O by O funds O earmarked O for O the O China B-ORG Agricultural I-ORG Research I-ORG System I-ORG CARS-3-1-17 O by O the O Science B-ORG and I-ORG Technology I-ORG Support I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BE2013432 O and O by O Jiangsu B-ORG Agriculture I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Fund I-ORG CX(15)1001 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O program O was O financially O supported O in O part O by O National B-ORG Key I-ORG R I-ORG I-ORG D I-ORG Program I-ORG for I-ORG Crop I-ORG Breeding I-ORG 2018YFD0100400 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG in I-ORG China I-ORG U1903203 O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG KYYJ201901 O Jiangsu B-ORG Collaborative I-ORG Innovation I-ORG Center I-ORG for I-ORG Modern I-ORG Crop I-ORG Production I-ORG project I-ORG No.10 O The O funders O were O not O involved O in O the O experimental O design O of O the O study O data O collection O analysis O and O interpretation O and O in O writing O the O manuscript O This O study O was O funded O by O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31372454 O the O Independent B-ORG Innovation I-ORG Fund I-ORG of I-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG in I-ORG Jiangsu I-ORG Province I-ORG CX(17)2027 O the O Jiangsu B-ORG fishery I-ORG science I-ORG and I-ORG technology I-ORG project I-ORG D2017-3-1 O and O the O Priority O Academic O Program O Development O of O Jiangsu O Higher O Education O Institutions O PAPD O The O funding O bodies O did O not O exert O influence O on O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O or O in O writing O of O the O manuscript O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 82204006 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG H2020209039 O and O the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Hebei I-ORG Education I-ORG Department I-ORG No. O QN2022170 B-AWARD and O Technology B-ORG Project I-ORG of I-ORG Tangshan I-ORG No. O 21130208c B-AWARD Non-profit B-ORG Central I-ORG Research I-ORG Institute I-ORG Fund I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Medical I-ORG Science I-ORG 2020-PT320-005 O Project B-ORG of I-ORG Key I-ORG Laboratory I-ORG of I-ORG Functional I-ORG and I-ORG Clinical I-ORG Translational I-ORG Medicine I-ORG XMMC-FCTM202202 O This O work O was O supported O by O CAMS O Initiative O for O Innovative O Medicine O CAMS-I2M O Grant O No. O 2016-I2M-2-006 O National B-ORG Key I-ORG Laboratory I-ORG of I-ORG Human I-ORG Factors I-ORG Engineering I-ORG China I-ORG Astronaut I-ORG Research I-ORG and I-ORG Training I-ORG Center I-ORG Grant O No. O SYFD150051808K B-AWARD PLA B-ORG General I-ORG Armament I-ORG Department I-ORG Grant O No. O 51326050501 B-AWARD and O the O Medicinal B-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Project I-ORG Grant O No. O BWS11J052 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31402047 O by O the O Earmarked B-ORG Fund I-ORG for I-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG No. O CARS-39 O and O by O a O Project B-ORG of I-ORG Shandong I-ORG Province I-ORG Higher I-ORG Educational I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG J18KA136 O This O study O was O supported O by O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG of I-ORG China I-ORG Grant O No.2017ZC0276 O Medical B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG of I-ORG China I-ORG Grant O No.A2019509 O Key B-ORG R I-ORG I-ORG D I-ORG and I-ORG Planning I-ORG projects I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Grant O No.2018YFC2001805 O The O work O was O supported O by O Grants O from O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2018YFC2000400 B-AWARD The B-ORG Second I-ORG Tibetan I-ORG Plateau I-ORG Scientific I-ORG Expedition I-ORG and I-ORG Research I-ORG No. O 2019QZKK0607 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 91749109 O 81701394 B-AWARD and O Key B-ORG Research I-ORG Program I-ORG of I-ORG Frontiers I-ORG Science I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG QYZDB-SSW-SMC020 O This O work O was O supported O by O the B-ORG National I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 O Program O No.2014CB744600 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No.61210010 I-AWARD No.61632014 O the B-ORG Program I-ORG of I-ORG International I-ORG S&T I-ORG Cooperation I-ORG of I-ORG MOST I-ORG No.2013DFA11140 O Program B-ORG of I-ORG Beijing I-ORG Municipal I-ORG Science I-ORG I-ORG Technology I-ORG Commission I-ORG No.Z171100000117005 O the B-ORG National I-ORG key I-ORG research I-ORG and I-ORG development I-ORG program I-ORG of I-ORG China(No.2016YFC1307203 O and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG lzujbky-2017-kb08 O The O National O Basic O Research O Program O of O China O 973 O Program O and O the O National O Natural O Science O Foundation O of O China O both O played O an O important O role O in O the O design O analysis O and O manuscript O revising O the O others O made O contributions O to O the O data O collection O This O research O was O funded O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China O 2018YFC0309804 B-AWARD to O LG, O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O 41506173 B-AWARD to O MY, O and O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences O XDB06010101 B-AWARD to O XL. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Chongqing B-ORG technology I-ORG innovation I-ORG and I-ORG application I-ORG demonstration I-ORG Project I-ORG cstc2018jscx-mszdX0081 O the O Chongqing B-ORG technological I-ORG innovation I-ORG and I-ORG application I-ORG development I-ORG special I-ORG project I-ORG cstc2020jscx-lyggx0005 O the O Chongqing B-ORG Social I-ORG Enterprise I-ORG People’s I-ORG Livelihood I-ORG Guarantee I-ORG Science I-ORG Technology I-ORG Innovation I-ORG Special I-ORG Project I-ORG cstc2017shms-zdyfx0025 O and O Chongqing B-ORG Postgraduate I-ORG Research I-ORG and I-ORG Innovation I-ORG Project I-ORG CYS21120 O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFC1700701 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81891014 B-AWARD the O Ministry B-ORG of I-ORG Finance I-ORG Central I-ORG Level I-ORG of I-ORG the I-ORG Special I-ORG No. O 2060302 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG public I-ORG welfare I-ORG research I-ORG institutes I-ORG No. O ZZ13-YQ-096 B-AWARD This O work O was O funded O by O Overseas B-ORG Distinguished I-ORG Scholar I-ORG Project I-ORG of I-ORG SCBG I-ORG to O J.S O Heslop-Harrison O Y861041001 O Undergraduate B-ORG Innovation I-ORG Training I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG 59 O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Science I-ORG XDA13020602 O and O Special O Basic O Research O Foundation O of O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG People’s I-ORG Republic I-ORG of I-ORG China I-ORG 2013FY112100 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Shandong B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG No. O 2016CYJS01A03 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81472813 B-AWARD and O 81871895 B-AWARD and O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2018YFC1313200 B-AWARD This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Grant O No.2016YFE0101700 O the O Huaqiao B-ORG University I-ORG Grant O Grant O No.13Y0391 O the O Promotion B-ORG Program I-ORG for I-ORG Young I-ORG and I-ORG Middle-aged I-ORG Teacher I-ORG in I-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG of I-ORG Huaqiao I-ORG University I-ORG Grant O No. O ZQN-PY419 B-AWARD and O the O Subsidized B-ORG Project I-ORG for I-ORG Cultivating I-ORG Postgraduates’ I-ORG Innovative I-ORG Ability I-ORG in I-ORG Scientific I-ORG Research I-ORG of I-ORG Huaqiao I-ORG University I-ORG Grant O No. O 17011071006 B-AWARD The O recruitment O phase O of O the O EPIC-Potsdam O Study O was O supported O by O the O Federal O Ministry O of O Science O Germany O 01 O EA O 9401 O and O the O European B-ORG Union I-ORG SOC O 95201408 I-AWARD 05F02 O The O follow-up O of O the O EPIC-Potsdam O Study O was O supported O by O German B-ORG Cancer I-ORG Aid I-ORG 70-2488-Ha O I) O and O the O European B-ORG Community I-ORG SOC O 98200769 I-AWARD 05F02 O This O work O was O furthermore O supported O by O a O grant O from O the O German O Ministry O of O Education O and O Research O BMBF O and O the O State O of O Brandenburg O DZD O grant O 82DZD00302 O The O current O work O is O supported O by O the O National B-ORG Cancer I-ORG Center I-ORG NCC O South O Korea O grant O Nos O NCC-1610210 B-AWARD and O NCC-1810920 B-AWARD This O study O was O supported O by O the O National B-ORG Research I-ORG Foundation I-ORG NRF O of O Korea O No. O 2017M3A9C4065961 B-AWARD and O NRF-2017M3A9D5A01052449 O and O the O Korea B-ORG Basic I-ORG Science I-ORG Institute I-ORG T39623 O and O T39720 B-AWARD This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 32202801 B-AWARD Major O Science O and O Technology O Special O Project O in O Anhui O Province O grant O number O 202003a060200127 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Province I-ORG grant O numbers O 2008085QC138 B-AWARD 2008085MC91 O Key B-ORG Technologies I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Anhui I-ORG Province I-ORG grant O number O 202204c06020009 B-AWARD and O the O Special O Fund O for O Anhui O Agriculture O Research O System O grant O number O AHCYJXTX-05-13 O This O work O was O financially O supported O by O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017M612439 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31170078 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG 2015CFA085 O and O the O Fundamental O Research O Funds O for O HUST O 2017KFYXJJ212 O This O study O was O funded O by O Guangdong B-ORG Provincial I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2016A0202151171 O Guangzhou B-ORG Municipal I-ORG Bureau I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG 20152A011020 O and O Traditional B-ORG Chinese I-ORG Medicine I-ORG Bureau I-ORG of I-ORG Guangdong I-ORG Province I-ORG 20141179 O Funding O for O this O project O was O provided O by O the O Doctoral B-ORG Fund I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China O No. O 20092104110009 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Liaoning I-ORG No. O 2012408002 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province I-ORG Grant O No. O 2014021035 B-AWARD and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81601053 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31801745 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Chongqing O China O cstc2019jcyj-msxmX0403 O and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG XDJK2020B061 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61761019 O 61861017 O 61861018 O 61862024 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Province I-ORG Jiangxi O Province O Natural O Science O Fund O 20181BAB211014 O 20181BAB211013 O and O Foundation B-ORG of I-ORG Jiangxi I-ORG Educational I-ORG Committee I-ORG of I-ORG China I-ORG GJJ180352 O This O work O was O supported O by O grants O from O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG No. O XDB31000000 B-AWARD Special B-ORG Foundation I-ORG for I-ORG State I-ORG Basic I-ORG Working I-ORG Program I-ORG of I-ORG China I-ORG No. O 2013FY112300 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31570220 B-AWARD and O Wuhan B-ORG Botanical I-ORG Garden I-ORG CAS I-ORG No. O Y655261W03 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O National O Eye O Institute O National B-ORG Human I-ORG Genome I-ORG Research I-ORG Institute O National O Heart O Lung O and O Blood O Institute O National O Institute O of O Allergy O and O Infectious O Diseases O National O Institute O of O Diabetes O and O Digestive O and O Kidney O Diseases O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences O National O Institute O of O Mental O Health O of O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG U24HG007822 O National O Human O Genome O Research O Institute O U41HG007822 O U41HG002273 B-AWARD National O Institute O of O General O Medical O Sciences O R01GM080646 O P20GM103446 B-AWARD U01GM120953 B-AWARD Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG BB/M011674/1 O British B-ORG Heart I-ORG Foundation I-ORG RG/13/5/30112 O Open O Targets O Swiss O Federal O Government O through O the O State O Secretariat O for O Education O Research O and O Innovation O European O Molecular O Biology O Laboratory O core O funds O The O open O access O publication O charge O for O this O paper O has O been O waived O by O Oxford O University O Press O NAREditorial O Board O members O are O entitled O to O one O free O paper O per O year O in O recognition O of O their O work O on O behalf O of O the O journal O This O work O was O supported O by O the O Paracelsus B-ORG Medical I-ORG University I-ORG Research I-ORG Support I-ORG Fund I-ORG grants O PMU-FFF O R-20/02/130-BEN B-AWARD and O R-19/01/117-ROM B-AWARD and O by O the O Deutsche B-ORG Forschungsgemeinschaft I-ORG DFG O EN B-AWARD 1240/2-1 I-AWARD and O PN B-AWARD 458054460 O S.C.-D O and O L.B O were O supported O by O Wings B-ORG for I-ORG Life I-ORG Spinal I-ORG Cord I-ORG Research I-ORG Foundation I-ORG WFL-AT-02/21 B-AWARD This O study O was O supported O by O grants O from O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG the I-ORG People’s I-ORG Republic I-ORG of I-ORG China I-ORG 2020YFA0803300 O Z.L O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82188102 O 82030074 B-AWARD Z.L O 81902423 B-AWARD D.G O Zhejiang B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Key I-ORG Project I-ORG LD21H160003 O Z.L O and O the O Leading B-ORG Innovative I-ORG and I-ORG Entrepreneur I-ORG Team I-ORG Introduction I-ORG Program I-ORG of I-ORG Zhejiang I-ORG 2019R01001 O Z.L O Z.L O is O the O Kuancheng O Wang O Distinguished O Chair O This O work O was O supported O by O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG in I-ORG Rural I-ORG Areas I-ORG of I-ORG the12th I-ORG Five-Year I-ORG Plan I-ORG Grant O No. O 2015BAD12B02-7 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31702260 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2016M601408 B-AWARD and O the O “Young B-ORG Talents” I-ORG Project I-ORG of I-ORG Northeast I-ORG Agricultural I-ORG University I-ORG 16QC24 O This O research O was O funded O by O the O Guizhou B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG QKHJC-ZK O 2022]ZD022 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32260686 O and O Guizhou B-ORG Medical I-ORG University I-ORG J O 2022]040 O This O research O was O supported O by O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017M621839 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20150462 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31501974 B-AWARD The O OncoImmunology O group O is O funded O by O the B-ORG Spanish I-ORG Association I-ORG against I-ORG Cancer I-ORG AECC O PROYE16001ESCO B-AWARD Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III I-ORG ISCIII)-FEDER I-ORG project O grants O FIS O PI17/02119 O FIS B-AWARD PI20/00010 O COV20/00000 B-AWARD and O TRANSPOCART B-AWARD ICI19/00069 O a O Biomedicine O Project O grant O from O the B-ORG Department I-ORG of I-ORG Health I-ORG of I-ORG the I-ORG Government I-ORG of I-ORG Navarre I-ORG BMED O 050-2019 O Strategic O projects O from O the B-ORG Department I-ORG of I-ORG Industry I-ORG Government I-ORG of I-ORG Navarre I-ORG AGATA O Ref I-AWARD 0011-1411-2020-000013 O LINTERNA B-AWARD Ref I-AWARD 0011-1411-2020-000033 O DESCARTHES B-AWARD 0011-1411-2019-000058 O This O project O has O received O funding O from O the O European B-ORG Union’s I-ORG Horizon I-ORG 2020 I-ORG research I-ORG and I-ORG innovation I-ORG programme I-ORG under O grant O agreement O No O 848166 B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Institutes I-ORG of I-ORG Health O Contract O grant O numbers O R21DA032791 B-AWARD to O EDM O 1R01DA038709 B-AWARD to O EDM O 1R21DA040852 B-AWARD to O EDM O and O K02DA031750 B-AWARD to O KPC O HL O was O supported O by O the O Biomedical O Engineering O Program O at O Yale B-ORG University I-ORG and O Robert B-AWARD E. I-AWARD Apafel I-AWARD Fellowship O YZ O was O supported O by O the O Interdepartmental O Neuroscience O Training O Program O at O Yale O University O T32NS4122813 O Gruber O Science O Foundation O Fellowship O and O the O National B-ORG Science I-ORG Foundation I-ORG Graduate O Research O Fellowship O Program O NSF-GRFP O This O work O was O supported O by O the O Science B-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG of I-ORG Hebei I-ORG Province O grant O number O 17C1303101018 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province O grant O number O E2021402002 B-AWARD the O Department B-ORG of I-ORG Education I-ORG of I-ORG Hebei I-ORG Province O grant O number O ZD2020195 B-AWARD and O the O Science O Foundation I-ORG of I-ORG Handan I-ORG City O grant O number O 21422111221 B-AWARD This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81772639 B-AWARD No. O 81472327 B-AWARD the O Major B-ORG State I-ORG Basic I-ORG Research I-ORG Development I-ORG Programme I-ORG of I-ORG China I-ORG 973 O Programme O No. O 2014CB542300 B-AWARD the O Chinese B-ORG Academy I-ORG Medical I-ORG Science I-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG No. O 2016-I2M-1-001 B-AWARD and O the O Non-profit B-ORG Central I-ORG Research I-ORG Institute I-ORG Fund I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG No. O 2018PT32014 B-AWARD No. O 2018PT32002 B-AWARD The O work O of O MIL O on O this O workflow O was O supported O by O the O National B-ORG Human I-ORG Genome I-ORG Research I-ORG Institute I-ORG R01HG009125 O the O National B-ORG Cancer I-ORG Institute I-ORG P01CA142538 O and O the O National B-ORG Institute I-ORG of I-ORG Environmental I-ORG Health I-ORG Sciences I-ORG P30 O ES010126 B-AWARD CS O declared O that O no O grants O were O involved O in O supporting O this O work O The O work O of O RP O on O this O workflow O was O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG BIO-1564917 O and O CCF-1750472 B-AWARD This O work O is O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project O 2018YFC2001100 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC I-ORG 61574017 O and I-AWARD 21673114 O and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG Central I-ORG Universities I-ORG 2017CX10007 O and I-AWARD 021014380116 O The O funds O for O conducting O this O experiment O were O provided O by O the O Youth O Innovation O Promotion O Association O Chinese O Academy O of O Sciences O the O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG President’s I-ORG International I-ORG Fellowship I-ORG Initiative I-ORG No. O 2016VBA050 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 91531303 B-AWARD the O International B-ORG Cooperation I-ORG Program I-ORG of I-ORG Bureau I-ORG of I-ORG International I-ORG Cooperation I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG No.GJHZ1559 O and O the O Animal O Branch O of O the O Germplasm O Bank O of O Wild O Species O Chinese O Academy O of O Sciences O the O Large O Research O Infrastructure O Funding O This O research O was O funded O by O the O National B-ORG Key I-ORG Program I-ORG 2017YFD0201200 O to O WS O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31772221 O to O WS O and O ST O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG funded I-ORG projects I-ORG 2017M611056 O to O ST O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG LZY23E050004 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51605440 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Provincial I-ORG Universities I-ORG of I-ORG Zhejiang I-ORG RF-A2020003 O This O study O was O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O SQ2017YFSF090114 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31470879 B-AWARD 31770960 B-AWARD 81373207 B-AWARD 81771733 B-AWARD and O 81861138010 B-AWARD and O CAS B-ORG Interdisciplinary I-ORG Innovation I-ORG team I-ORG Frontier I-ORG Science I-ORG Key I-ORG Research I-ORG Project I-ORG QYZDB-SSW-SMC036 O and O the B-ORG Strategic I-ORG Priority I-ORG Research I-ORG Program I-ORG No. O XDPB0303 B-AWARD and O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG No. O 2014CB541904 B-AWARD This O research O was O funded O by O the O Scientific B-ORG Research I-ORG and I-ORG Sharing I-ORG Platform I-ORG Construction I-ORG project I-ORG of I-ORG Shaanxi I-ORG Province O grant O number O 2021PT-036 B-AWARD the O Crop B-ORG Breeding I-ORG Key I-ORG Project I-ORG of I-ORG “Two I-ORG Chains” I-ORG Fusion I-ORG of I-ORG Shaanxi I-ORG Province O grant O number O 2021LLRH-07 B-AWARD the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Henan I-ORG Province O grant O number O 221111110200 B-AWARD the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Yangling I-ORG Seed I-ORG Industry I-ORG Innovation I-ORG Center O grant O number O Ylzy-yc-2021-02 B-AWARD and O the O Shaanxi B-ORG Creative I-ORG Talents I-ORG Promotion I-ORG Plan-Technological I-ORG Innovation I-ORG Team O grant O number O 2020TD-051 B-AWARD This O research O was O supported O by O National O Key O R O O D O Program O of O China O No. O 2017YFD0202000 O the O earmarked O fund O for O the O China B-ORG Agricultural I-ORG Research I-ORG System I-ORG No. O CARS-26 B-AWARD International O Atomic O Energy O Agency’s O Coordinated O Research O Project O No. O D42016 O and O No. O D44003 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 31872931 B-AWARD and O 31572008 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 2662019PY055 B-AWARD This O study O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81572297 O and O 81772515 B-AWARD Medical B-ORG Transformation I-ORG Cross I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG ZH2018QNA49 O and O Doctoral B-ORG Innovation I-ORG Fund I-ORG Projects I-ORG from I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG School I-ORG of I-ORG Medicine I-ORG BXJ201725 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O Technology B-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG Grant O No. O 2018C02012 B-AWARD This O research O was O supported O by O NIH O grants O P20RR016477 O from O the O National O Center O for O Research O Resources O and O P20GM103434 O from O the O National O Institute O for O General O Medical O Sciences O NIGMS O awarded O to O the O West O Virginia O IDeA O Network O of O Biomedical O Research O Excellence O This O study O was O also O supported O by O Grant O No. O P20GM104932 O from O NIGMS O a O component O of O the O National O Institutes O of O Health O NIH O and O its O contents O are O solely O the O responsibility O of O the O authors O and O do O not O necessarily O represent O the O official O view O of O NIGMS O or O NIH O This O study O was O also O supported O by O COBRE O grant O GM102488/RR032138 O ARIA O S10 O grant O RR020866 O FORTESSA O S10 O grant O OD016165 O and O INBRE O grant O GM103434 O This O research O was O also O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31501474 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG Grant O No. O LY15C200007 B-AWARD This O work O is O supported O partly O by O grants O from O the B-ORG National I-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG of I-ORG China I-ORG to O SY O 81373379 O 81641186 B-AWARD to O LS O 21302234 O the B-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG of I-ORG Wuhan I-ORG City I-ORG to O SY O 2017030209020256 O and O the B-ORG Key I-ORG Projects I-ORG of I-ORG Technological I-ORG Innovation I-ORG of I-ORG Hubei I-ORG Province I-ORG to O JL O 2016ACA138 O JBM O was O supported O by O a O training O fellowship O from O the O Burroughs B-ORG Wellcome I-ORG Fund I-ORG BWF)-The O Houston O Laboratory O and O Population O Science O Training O Program O in O Gene-Environment O Interaction O of O the O University O of O Texas O Health O Science O Center O at O Houston O BWF O Grant O No.1008200 O and O by O a O T32GM008307 B-AWARD from O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG NIGMS O The O project O described O was O also O supported O by O Grant O Number O C06RR029965 B-AWARD from O the O National B-ORG Center I-ORG for I-ORG Research I-ORG Resources I-ORG NCRR O This O work O was O also O supported O by O the O neurobehavioral O core O of O the O Baylor O College O of O Medicine O Intellectual B-ORG and I-ORG Developmental I-ORG Disabilities I-ORG Research I-ORG Center I-ORG IDDRC O supported O by O award O 1U54HD083092-04 B-AWARD from O the O Eunice O Kennedy O Shriver O National O Institute O for O Child O Health O and O Human O Development O NICHD O The O content O is O solely O the O responsibility O of O the O authors O and O does O not O represent O the O official O views O of O the O BWF O and O the O NIGMS O NCRR O and O NICHD O of O the O National O Institutes O of O Health O We O note O that O while O BKYW O is O a O current O employee O of O Noldus O Information O Technology O Inc O she O was O not O affiliated O with O Noldus O Information O Technology O Inc O in O any O shape O or O form O during O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O word O was O financially O supported O by O Key B-ORG Research I-ORG and I-ORG Discovery I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG 2019GSF107072 O High-Level B-ORG Talent I-ORG Research I-ORG Foundation I-ORG of I-ORG Qingdao I-ORG Agricultural I-ORG University I-ORG China I-ORG 1119007 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 31802229 O This O work O was O funded O by O the O Guangdong B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG 2019B21201005 O the O National B-ORG Key I-ORG Research I-ORG I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2022YFC3103700 O and O the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Zhanjiang I-ORG Guangdong I-ORG China I-ORG 2021A05030 O This O work O was O financially O supported O by O the O Shandong B-ORG Special I-ORG Fund I-ORG for I-ORG Qingdao I-ORG National I-ORG Laboratory I-ORG for I-ORG Marine I-ORG Science I-ORG and I-ORG Technology I-ORG 2022QNLM030004-4 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 42076090 O and O U2006203 B-AWARD the O Senior B-ORG User I-ORG Project I-ORG of I-ORG RV I-ORG KEXUE I-ORG KEXUE2020GZ02 O and O the O Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG ZR2021ZD28 O and O ZR2019ZD18 B-AWARD X.L O acknowledges O the O Youth B-ORG Innovation I-ORG Promotion I-ORG Association I-ORG CAS I-ORG 2023216 O The O samples O were O grown O under O the O support O of O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Higher I-ORG Education I-ORG of I-ORG the I-ORG Russian I-ORG Federation I-ORG state O task O No O 0791-2023-0004 B-AWARD The O SEM O measurements O were O performed O under O the O financial O support O of O St. B-ORG Petersburg I-ORG State I-ORG University I-ORG under O research O grant O No O 94031047 B-AWARD The O TEM O studies O were O conducted O using O the O facilities O of O the O Federal O Joint O Research O Center O ‘Materials O science O and O characterization O in O advanced O technology’ O The O optical O properties O were O measured O in O the O framework O of O the O Basic O Research O Program O at O the O HSE O University O The O modeling O part O of O this O research O has O been O carried O out O with O the O support O of O the O Russian B-ORG Science I-ORG Foundation I-ORG 21-12-00304 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O No. O 62274171 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai O grant O No. O 21ZR1474500 B-AWARD and O Shanghai B-ORG Technology I-ORG Innovation I-ORG Project O grant O Nos O 20DZ1100603 B-AWARD and O 22501100700 B-AWARD The O research O leading O to O these O results O has O received O financial O support O from O the O European B-ORG Research I-ORG Council I-ORG under O grant O agreement O no. O 337415 B-AWARD the O European O Community's O Seventh B-ORG Framework I-ORG Programme I-ORG FP7/2007-2013 O under O grant O agreement O no. O 241548 B-AWARD and O the O Medical B-ORG Research I-ORG Council I-ORG under O grant O agreement O no. O MC_U105192711 B-AWARD This O work O was O supported O by O grants O from O the O CAMS B-ORG Initiatives I-ORG for I-ORG Innovative I-ORG Medicine I-ORG 2016-I2M-1-018 O to O F.M O and O 2017-I2M-3-021 B-AWARD to O J.L O the O Sichuan B-ORG Provincial I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG research O project O 17PJ489 O to O B.C O and O Chengdu B-ORG Science I-ORG and I-ORG Technology I-ORG Project-Technology O Innovation O R&D O 2018-YF05-01341-SN O to O B.C O This O work O was O supported O by O the O State B-ORG Key I-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81430007 O the B-ORG National I-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81020108017 O and O 81500752 B-AWARD the O National B-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG China I-ORG 201302015 O the O New B-ORG Technology I-ORG Research I-ORG Project I-ORG Shanghai I-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG SHDC12014114 O and I-AWARD 2013SY058 O and O the B-ORG National I-ORG Major I-ORG Scientific I-ORG Equipment I-ORG Program I-ORG 2012YQ12008003 O The O sponsors O were O not O involved O in O the O design O or O conduct O of O this O research O This O study O was O supported O by O the B-ORG Key I-ORG Science I-ORG and I-ORG Technology I-ORG planning I-ORG Project I-ORG of I-ORG Yunnan I-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG No. O 2016FC005 O Foundation B-ORG of I-ORG Yunnan I-ORG Institute I-ORG of I-ORG Digestive I-ORG Disease I-ORG 2016NS003 O and O 2017NS003 B-AWARD Yunling B-ORG Scholar I-ORG YLXL20170002 O and O Foundation O of O Yunnan O Institute O of O Digestive O Disease O 2018NS0085 O This O study O was O supported O in O part O by O the O research O grants O of O National B-ORG Institute I-ORG of I-ORG Health I-ORG National I-ORG Institute I-ORG of I-ORG Biomedical I-ORG Imaging I-ORG and I-ORG Bioengineering I-ORG 1F31EB018152-01A1 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81370036 O and O 81130029 O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG China I-ORG 3332013105 O Capital B-ORG Clinically I-ORG Characteristic I-ORG Applied I-ORG Research I-ORG Fund I-ORG of I-ORG China I-ORG Z151100004015141 O and O Beijing O Natural O Science O Foundation O 7152124 O Project O support O was O kindly O provided O by O the B-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG ASTIP I-ORG of I-ORG China I-ORG grant O no. O CAAS-ASTIP-2016-LVRI-03 B-AWARD the B-ORG Fund I-ORG for I-ORG Shanxi I-ORG “1331 I-ORG Project” I-ORG grant O no. O 20211331-13 B-AWARD Special B-ORG Research I-ORG Fund I-ORG of I-ORG Shanxi I-ORG Agricultural I-ORG University I-ORG for I-ORG High-level I-ORG Talents I-ORG grant O no. O 2021XG001 B-AWARD the B-ORG Yunnan I-ORG Expert I-ORG Workstation I-ORG grant O no. O 202005AF150041 B-AWARD and O the B-ORG Veterinary I-ORG Public I-ORG Health I-ORG Innovation I-ORG Team I-ORG of I-ORG Yunnan I-ORG Province I-ORG grant O no. O 202105AE160014 B-AWARD This O work O was O supported O by O Beijing B-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospital I-ORG Program I-ORG QML20151002 O Beijing B-ORG Municipal I-ORG Senior I-ORG Technical I-ORG Training I-ORG Plan I-ORG in I-ORG Health I-ORG System I-ORG 2015-3-073 O and O Beijing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Z141100002114046 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82030031 O 82001067 B-AWARD grants O from O the O Chinese B-ORG Research I-ORG Unit I-ORG of I-ORG Tooth I-ORG Development I-ORG and I-ORG Regeneration I-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG 2019-12M-5-031 O the O Beijing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG Z181100001718208 O the O Beijing B-ORG Municipal I-ORG Education I-ORG Commission I-ORG 119207020201 O Beijing B-ORG Advanced I-ORG Innovation I-ORG Center I-ORG for I-ORG Big I-ORG Data-based I-ORG Precision I-ORG Medicine I-ORG PXM2021_014226_000026 O and O grants O from O the O Beijing O Municipal O Government O Beijing O Scholar I-ORG program—PXM2020_014226_000005 O PXM2021_014226_000020 B-AWARD Innovation B-ORG Research I-ORG Team I-ORG Project I-ORG of I-ORG Beijing I-ORG Stomatological I-ORG Hospital I-ORG Capital I-ORG Medical I-ORG University I-ORG CXTD202201 O Beijing B-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospitals’ I-ORG Youth I-ORG Program I-ORG QML20191504 O Scientific B-ORG Research I-ORG Common I-ORG Program I-ORG of I-ORG Beijing I-ORG Municipal I-ORG Commission I-ORG of I-ORG Education I-ORG KM202110025009 O and O Beijing B-ORG Talents I-ORG Fund I-ORG 2018000021469G285 O We O received O funding O from O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2020YFA0707602 O to O L.S O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82272328 O to O L.S O and O the O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG CIFMS O 2022-I2M-1-011 O to O L.S O Special B-ORG Fund I-ORG of I-ORG the I-ORG Chinese I-ORG Central I-ORG Government I-ORG for I-ORG Basic I-ORG Scientific I-ORG Research I-ORG Operations I-ORG in I-ORG the I-ORG Public I-ORG Research I-ORG Institutes(NO O 2015GJZ03 O The B-ORG new I-ORG teacher I-ORG project I-ORG of I-ORG Education I-ORG Ministry I-ORG 20134423120005 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Funds I-ORG of I-ORG China I-ORG 81401205 B-AWARD Scientific B-ORG Research I-ORG Project I-ORG of I-ORG Guangzhou I-ORG Science I-ORG and I-ORG Information I-ORG Bureau I-ORG 2014J4100024 B-AWARD This O work O was O supported O by O the O State B-ORG Committee I-ORG of I-ORG Science I-ORG Armenia I-ORG project O 21AG-4D065 B-AWARD by O the O Ministry B-ORG of I-ORG Innovative I-ORG Development I-ORG of I-ORG the I-ORG Republic I-ORG of I-ORG Uzbekistan O grant O EAPI-2021-51 B-AWARD and O by O the O Russian B-ORG Foundation I-ORG for I-ORG Basic I-ORG Research O project O no. O 20-516-81004\20 B-AWARD The O research O leading O to O these O results O has O received O support O from O the O Innovative B-ORG Medicines I-ORG Initiative I-ORG Joint I-ORG Undertaking I-ORG under O EMIF B-AWARD grant I-AWARD agreement I-AWARD n° I-AWARD 115372 O resources O of O which O are O composed O of O financial O contribution O from O the O European O Union’s O Seventh O Framework O Programme O FP7/2007–2013 O and O EFPIA O companies’ O in-kind O contribution O This O research O was O funded O in O part O through O the O NIH/NCI B-ORG Cancer I-ORG Center I-ORG Support I-ORG Grant O P30 B-AWARD CA008748 O DS O and O participation O in O CSF O proficiency O testing O was O supported O by O the O Polish B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Higher I-ORG Education I-ORG grant O DIR/WK/2017/01 B-AWARD CT O received O grants O from O the O European O Commission O the O Dutch O Research O Council O ZonMW O Association O of O Frontotemporal O Dementia/Alzheimer’s O Drug O Discovery O Foundation O and O Alzheimer O Netherlands O The O current O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 81571490 B-AWARD 81501313 B-AWARD and O 81701453 B-AWARD Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG China I-ORG Grant O No. O ZR2014HQ068 B-AWARD the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG Grant O No. O 2017GSF18163 B-AWARD and O Yantai B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG Grant O No. O 2016WS001 B-AWARD The O present O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81800961 O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2016B030229003 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2018A030313098 O and O Medical B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG B2020158 O This O study O was O supported O by O Tianjin B-ORG science I-ORG and I-ORG technology I-ORG innovation I-ORG system I-ORG and I-ORG the I-ORG condition I-ORG of I-ORG platform I-ORG construction I-ORG plan I-ORG Grant O 14TXSYJC00572 B-AWARD Innovation B-ORG fund I-ORG for I-ORG technology I-ORG based I-ORG firms I-ORG Grant O 12ZXCXSY06500 B-AWARD and O Grant O 12ZXCXSY07200 B-AWARD Open B-ORG fund I-ORG project I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Medicinal I-ORG Chemical I-ORG Biology I-ORG Grant O 2018128 B-AWARD This O work O was O supported O by O the O Modern B-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG CARS-34 O the O Sichuan B-ORG International I-ORG Cooperation I-ORG Projects I-ORG 2017HH0071 O and O the O Sichuan B-ORG Province I-ORG Breeding I-ORG Research I-ORG grant I-ORG 2016NYZ0039 O the O project O was O also O partially O supported O by O USDA-NIFA B-ORG Grant O Number O 2011-67009-30133 B-AWARD to O BZ, O and O the O Virginia B-ORG Agricultural I-ORG Experiment I-ORG Station I-ORG VA135872 O and O the O National B-ORG High-Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 863 I-ORG Program I-ORG of I-ORG China I-ORG No. O 2012AA101801-02 B-AWARD This O work O was O supported O by O the O Hubei B-ORG Provincial I-ORG Major I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG 2016ABA113 O National B-ORG Key I-ORG Technology I-ORG Support I-ORG Program I-ORG 2014BAD20B00 O National B-ORG Key I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Hubei I-ORG Province I-ORG of I-ORG China I-ORG 2014ABC012 O Hubei B-ORG Provincial I-ORG Key I-ORG Technology I-ORG Support I-ORG Program I-ORG 2014ABB014 O Hubei B-ORG Provincial I-ORG Creative I-ORG Team I-ORG Project I-ORG of I-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG 2007-062 O The O authors O would O like O to O thank O the O support O of O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 11302076 B-AWARD to O SD, O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG No. O A2014502047 B-AWARD to O SD O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 2014MS111 B-AWARD to O SD. O This O work O was O supported O by O grants O from O the O National B-ORG Key I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG no. O 2012BAD14B12-03 B-AWARD the O Exploratory B-ORG and I-ORG Paradigm-shifting I-ORG Innovation I-ORG Project I-ORG of I-ORG Jiangsu I-ORG China I-ORG no. O ZX(17)2001 B-AWARD and O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Demonstration I-ORG Project I-ORG of I-ORG Suzhou I-ORG China I-ORG no. O SNG201645 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51374069 I-AWARD and O No. B-AWARD 51704065 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M630297 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG China I-ORG No. O N170204013 O The O work O was O partly O supported O by O grants O from O the O National O Brain O Research O Program O KTIA-NAP-13-1-2013-0001 O the O New B-ORG National I-ORG Excellence I-ORG Program I-ORG UNKP-17-3 O of O the O Ministry O of O Human O Resources O of O the O Government O of O Hungary O and O by O Semmelweis B-ORG University I-ORG EFOP-3.6.3-VEKOP-16-2017-00009 O DB, O AA O and O FO O were O supported O by O the O grant O no. O KTIA-NAP-13-1-2013-0001 O from O the O Hungarian B-ORG Brain I-ORG Research I-ORG Program I-ORG and O by O the O New O National O Excellence O Program O UNKP-17-3 O IS O was O supported O by O the O grant O no. O EFOP-3.6.3-VEKOP-16-2017-00009 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript.http://www.agykutatas.com;http://www.kormany.hu/hu/emberi-eroforrasok-miniszteriuma/oktatasert-felelos-allamtitkarsag/hirek/az-uj-nemzeti-kivalosag-program O This O project O was O sponsored O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31972924 O the O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG 21DZ2208200 O 22S31906000 B-AWARD and O the O Pudong B-ORG Science I-ORG Technology I-ORG and I-ORG Economy I-ORG Commission I-ORG 210H1147900 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 41801036 O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFE0100700 O the O Key B-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41730646 O the O project O from O the O Key B-ORG Laboratory I-ORG for I-ORG Mountain I-ORG Hazards I-ORG and I-ORG Earth I-ORG Surface I-ORG Process I-ORG Institute I-ORG of I-ORG Mountain I-ORG Hazards I-ORG and I-ORG Environment I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG KLMHESP-17-02 O and O the O project O from O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Cryospheric I-ORG Sciences I-ORG Cold I-ORG and I-ORG Arid I-ORG Regions I-ORG Environment I-ORG and I-ORG Engineering I-ORG Research I-ORG Institute I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG SKLCS-OP-2016-04 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O Beijing B-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospitals I-ORG Clinical I-ORG Medicine I-ORG Development I-ORG of I-ORG Special I-ORG Funding I-ORG Support I-ORG No.ZYLX201312 O in O part O by O a O grant O from O Beijing B-ORG High-Grade I-ORG Talents I-ORG Health I-ORG Technology I-ORG Fund I-ORG No.2011-2-06 O and O Capital B-ORG Health I-ORG Research I-ORG and I-ORG Development I-ORG of I-ORG Special I-ORG Funding I-ORG Support I-ORG No.2016-1-1061 O The O study O was O financed O by O the O Faculty B-ORG of I-ORG Biology I-ORG University I-ORG of I-ORG Gdańsk I-ORG grant O no. O 538-L150-B583-14 B-AWARD This O research O received O support O from O the O SYNTHESYS O Project O http://www.synthesys.info O which O is O financed O by O European B-ORG Community I-ORG Research I-ORG Infrastructure I-ORG Action I-ORG under I-ORG the I-ORG FP7 I-ORG “Capacities” I-ORG Program I-ORG GB-TAF-2445 O and O from O the O grant O no. O 14-36098G B-AWARD of O the O Grantová B-ORG agentura I-ORG České I-ORG republiky I-ORG GA I-ORG ČR O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 51873207 B-AWARD 51803006 I-AWARD 51833010 I-AWARD 51673190 I-AWARD 51603204 I-AWARD 51673187 I-AWARD and I-AWARD 51520105004 O the O Science B-ORG and I-ORG Technology I-ORG Development I-ORG Program I-ORG of I-ORG Jilin I-ORG Province I-ORG Grant O No. O 20190201068JC B-AWARD and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2016YFC1100701 B-AWARD This O study O was O financially O supported O by O the O Major O projects O of O Inner B-ORG Mongolia I-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2020ZD06 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31702161 O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2014CB138806 O the O Inner O Mongolia O Natural O Science O Foundation O 2017MS0379 O and O the O Inner O Mongolia O Natural O Science O Foundation O 2020MS03070 O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFA0903400 O Natural O Science O Foundation O of O Jiangsu O Province O of O China O BK20190893 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2019M651984 O a O project O funded O by O the O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O and O Lift O Engineering O of O Young O Talents O of O Jiangsu O Association O for O Science O and O Technology O This O research O was O supported O by O grants O from O The B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFC0501406 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG funded I-ORG project I-ORG 2018M643823XB O The B-ORG Youth I-ORG Innovation I-ORG Talent I-ORG Program I-ORG of I-ORG Shihezi I-ORG University I-ORG CXPY201910 O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Xinjiang I-ORG Production I-ORG and I-ORG Construction I-ORG Corps I-ORG 2019AB038 O and O Startup B-ORG Foundation I-ORG for I-ORG Advanced I-ORG Talents I-ORG of I-ORG Shihezi I-ORG University I-ORG RCSX2018B08 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O project O was O supported O by O the O consolidator O fellowship O from O the O European B-ORG Research I-ORG Council I-ORG ERC O SENSOILS-647857 O LXD O MM O We O also O acknowledge O the O funding O from O the O Spanish B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Innovation I-ORG under O de O project O MICROCROWD O PID2020-112950RR-I00 B-AWARD LXD O The O James O Hutton O Institute O received O support O from O the O Scottish O Government O Rural O and O Environment O Science O and O Analytical O Services O Division O RESAS O Work O package O 1.1.1,2.1.6,2.1.7,2.3.4 B-AWARD MM O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O nos O 81273743 B-AWARD and I-AWARD 81473641 O the O 215 B-ORG Program I-ORG from I-ORG Beijing I-ORG Municipal I-ORG Health I-ORG Bureau I-ORG 2013-2-11 O and O the O Collaborative B-ORG Innovation I-ORG Center I-ORG of I-ORG Infectious I-ORG diseases I-ORG PXM O 2015-014226-000058 O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0600705 O Beijing B-ORG Forestry I-ORG University I-ORG Outstanding I-ORG Young I-ORG Talent I-ORG Cultivation I-ORG Project I-ORG 2019JQ03004 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31722011 O This O study O was O supported O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81470978 B-AWARD 81279834 O Major B-ORG Program I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG No. O 2015B020226005 B-AWARD Key B-ORG Project I-ORG of I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG No. O 2015A030311040 B-AWARD Leading B-ORG Scientific I-ORG Technical I-ORG and I-ORG Innovation I-ORG Talents I-ORG of I-ORG Guangdong I-ORG Special I-ORG Support I-ORG Program(No O 510204006192 B-AWARD The O funding O organizations O did O not O have O any O role O in O the O study O design O collection O analysis O or O interpretation O of O data O in O writing O of O the O manuscript O or O in O the O decision O to O submit O the O article O for O publication O This O work O was O supported O by O the O Guizhou B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG 2020]-1Z021 B-AWARD the O China B-ORG National I-ORG Tobacco I-ORG Corporation I-ORG Guangxi I-ORG Zhuang I-ORG Autonomous I-ORG Region I-ORG Company I-ORG 202145000024006 B-AWARD and O the O Program O of O Excellent B-ORG Innovation I-ORG Talents I-ORG Guizhou I-ORG Province O China O 20206003 B-AWARD This O study O is O supported O by O five O key O funds O The O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG China I-ORG JD22A012 O GZ20210206 B-AWARD China B-ORG Railway I-ORG 22 I-ORG Bureau I-ORG Group I-ORG Co I-ORG LTD I-ORG Science I-ORG and I-ORG technology I-ORG research I-ORG project I-ORG 20-01A O The O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG China I-ORG 2572020AW53 O 2572019CP02 B-AWARD The O study O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFC1000307 O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG sciences I-ORG 2018-I2M-1-004 O and O Beijing B-ORG Talents I-ORG Foundation I-ORG from I-ORG organization I-ORG department I-ORG of I-ORG Beijing I-ORG municipal I-ORG committee I-ORG of I-ORG the I-ORG CPC I-ORG grant O number I-AWARD 2016000021223ZK20 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Suzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG SYS201649 O Suzhou B-ORG Key I-ORG Medical I-ORG Center I-ORG SZZX201505 O Jiangsu B-ORG Maternal I-ORG and I-ORG Children I-ORG Health I-ORG Care I-ORG Research I-ORG Project I-ORG F201603 O Jiangsu B-ORG Provincial I-ORG Medical I-ORG Innovation I-ORG Team I-ORG CXTDB2017013 O Suzhou B-ORG Clinical I-ORG Medical I-ORG Expert I-ORG Team I-ORG SZYJTD201708 O and O Jiangsu B-ORG Maternal I-ORG and I-ORG Children I-ORG Health I-ORG Care I-ORG Key I-ORG Discipline I-ORG FXK201748 O FXK201754 O The O four O sources O of O funding O for O this O research O reported O are O listed O as O follows O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 863 O Program O Research O and O development O for O cerebral O vascular O real-time O interventional O therapy O with O mobile O surgical O robot O system O Grant O No. O 2015AA043203 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Computer-assisted O analysis O and O clinical O application O research O of O cerebral O arteriovenous O malformations O based O on O MRA O Grant O No. O 61471349 B-AWARD Basic B-ORG Discipline I-ORG Layout I-ORG Project I-ORG of I-ORG Shenzhen I-ORG City I-ORG Research O of O surgical O vessel O intervention O with O immersing O multi-perception O mode O Grant O No. O JCYJ20150731154850923 B-AWARD and O Technology B-ORG innovation I-ORG program I-ORG of I-ORG Shenzhen I-ORG City I-ORG Research O and O development O of O minimally O invasive O spinal O surgery O system O based O on O multi-modality O imaging O and O Intraoperative O navigation O Grant O No. O JSGG20160229203812944 B-AWARD The O first O funding O provides O support O in O the O design O of O this O study O the O second O one O and O the O third O one O are O responsible O for O data O collection O and O the O last O one O for O data O analysis O This O work O was O financially O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD1000300 O 2017YFD0202000 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31772280 O and O the O National B-ORG Citrus I-ORG Engineering I-ORG Research I-ORG Center I-ORG NCERC2019001 O The O funders O provided O the O financial O support O to O the O RNAseq O but O didn’t O play O role O in O in O the O design O of O the O study O collection O analysis O interpretation O of O data O and O in O writing O the O manuscript O This O study O was O supported O by O the O Southeast B-ORG Asia I-ORG Biodiversity I-ORG Research I-ORG Institute I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG no. O 2015CASEABRIRG001 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG nos O 31670338 B-AWARD 31400286 O and O the O National B-ORG Science I-ORG I-ORG Technology I-ORG Fundamental I-ORG Resources I-ORG Investigation I-ORG Program I-ORG of I-ORG China I-ORG no. O 2018FY100700 B-AWARD This O research O was O supported O by O the O Swiss B-ORG National I-ORG Science I-ORG Foundation I-ORG Grant O P2BEP3_168670 B-AWARD to O R.S O by O the O Rosetrees B-ORG Trust I-ORG Grant O A1699 B-AWARD to O A.D.H O and O M.A.L.R O by O the O Medical B-ORG Research I-ORG Council I-ORG Grant O MR/R023883/1 B-AWARD to O M.A.L.R O and O by O the O European B-ORG Research I-ORG Council I-ORG Grant O GAP O 670428 B-AWARD to O M.A.L.R O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31400602 O the O Henan B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Breakthrough I-ORG Project I-ORG 172102310054 O and O the O Applied B-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Fund I-ORG of I-ORG Luoyang I-ORG Normal I-ORG University I-ORG 2015-YYJJ-003 O The O funding O body O had O no O contribution O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O is O supported O by O Jiangsu B-ORG Province I-ORG Association I-ORG of I-ORG Maternal I-ORG and I-ORG Child I-ORG Health I-ORG Project I-ORG FYX201603 O Jiangsu B-ORG Provincial I-ORG commission I-ORG of I-ORG health I-ORG and I-ORG family I-ORG planning I-ORG H2017073 O Jiangsu B-ORG Maternal I-ORG and I-ORG Children I-ORG health I-ORG care I-ORG key I-ORG discipline I-ORG FXK201748 O Jiangsu B-ORG Maternal I-ORG and I-ORG Children I-ORG health I-ORG care I-ORG research I-ORG project I-ORG F201603 O Jiangsu B-ORG Provincial I-ORG Medical I-ORG Innovation I-ORG Team I-ORG CXTDB2017013 O Suzhou B-ORG Key I-ORG Medical I-ORG Center I-ORG SZZX201505 O Suzhou B-ORG Introduced I-ORG Project I-ORG of I-ORG Clinical I-ORG Medical I-ORG Expert I-ORG Team I-ORG SZYJTD201708 O Suzhou B-ORG Industry I-ORG Technology I-ORG Innovation I-ORG Project I-ORG SYS201770 O and O SS201873 B-AWARD and O Ningbo B-ORG Health I-ORG Branding I-ORG Subject I-ORG Fund I-ORG PPXK2018-06 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 62201149 B-AWARD 62271148 B-AWARD the O Ji B-ORG Hua I-ORG Laboratory I-ORG of I-ORG Guangdong I-ORG province I-ORG China I-ORG Grant O No. O X200051UZ200 B-AWARD the O Research B-ORG and I-ORG Development I-ORG Projects I-ORG in I-ORG Key I-ORG Areas I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2020B1111040001 O and O the O Research B-ORG Fund I-ORG of I-ORG Guangdong–Hong I-ORG Kong–Macao I-ORG Joint I-ORG Laboratory I-ORG for I-ORG Intelligent I-ORG Micro-Nano I-ORG Optoelectronic I-ORG Technology I-ORG No. O 2020B1212030010 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31960534 O the O Jiangsu O Seed O Industry O Revitalization O “The O open I-ORG competition I-ORG mechanism I-ORG to I-ORG select I-ORG the I-ORG best I-ORG candidates” O Project O JBGS O 2021]061 O the B-ORG TAČR-JSTD I-ORG Bilateral I-ORG Czech–China I-ORG Co-Funding I-ORG R&D I-ORG Project I-ORG BZ2020024 O and O TM01000044 B-AWARD and O the O Guizhou B-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG post-funded I-ORG project I-ORG of I-ORG the I-ORG NSFC I-ORG 2021]44 B-AWARD This O research O was O funded O by O “Systematic O Project I-ORG of I-ORG Guangxi I-ORG Key I-ORG Laboratory I-ORG of I-ORG Disaster I-ORG Prevention I-ORG and I-ORG Engineering I-ORG Safety O grant O number O 2019ZDK052” B-AWARD “National O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 51904093” B-AWARD “Henan O innovative I-ORG science I-ORG and I-ORG technology I-ORG team I-ORG support I-ORG project O grant O number O CXTD2017088” B-AWARD “Key O Laboratory I-ORG Open I-ORG Foundation I-ORG of I-ORG Henan I-ORG Polytechnic I-ORG University O grant O number O SJF20180” B-AWARD “Key O Research I-ORG and I-ORG Development I-ORG and I-ORG Promotion I-ORG of I-ORG Special I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Henan I-ORG Province O grant O number O 192102310247” B-AWARD “Exploration O of I-ORG Youth I-ORG Innovation I-ORG Foundation I-ORG of I-ORG Henan I-ORG Polytechnic I-ORG University O grant O number O NSFRF180321” B-AWARD This O work O was O supported O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Fund I-ORG 81071024 O 81171202 I-AWARD 81471287 I-AWARD 81371407 I-AWARD and I-AWARD 81228007 O Shanghai B-ORG Shuguang I-ORG Program I-ORG 11SG20 O and O Shanghai B-ORG Municipal I-ORG Education I-ORG Commission—Gaofeng I-ORG Clinical I-ORG Medicine I-ORG Grant I-ORG Support O 20152201 O This O work O was O supported O by O a O Hungarian B-ORG Scientific I-ORG Research I-ORG Grant I-ORG of I-ORG the I-ORG National I-ORG Research I-ORG Development I-ORG and I-ORG Innovation I-ORG Office I-ORG NKFI B-AWARD FK I-AWARD 135065 O the O New B-ORG National I-ORG Excellence I-ORG Program I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Human I-ORG Capacities I-ORG UNKP-22-5-SE-1 O given O to O H.B O and O by O the O Ministry B-ORG of I-ORG Innovation I-ORG and I-ORG Technology I-ORG of I-ORG Hungary I-ORG from I-ORG the I-ORG National I-ORG Research I-ORG Development I-ORG and I-ORG Innovation I-ORG Fund O financed O under O the O TKP2021-EGA/TKP2021-NVA/TKP2021-NKTA B-AWARD funding O scheme O given O to O A.P O H.B O is O a O recipient O of O the O Bolyai O Research O Fellowship O of O the O Hungarian O Academy O of O Sciences O H.B O and O A.P O acknowledge O financial O support O from O the O National B-ORG Laboratories I-ORG Excellence I-ORG program I-ORG under O the O National O Tumour O Biology O Laboratory O project O NLP17 O and O the O Hungarian B-ORG Thematic I-ORG Excellence I-ORG Programme I-ORG TKP2021-EGA-44 O This O research O was O supported O by O a O grant O KDDF-201212-12 O from O the B-ORG Korea I-ORG Drug I-ORG Development I-ORG Fund I-ORG KDDF I-ORG funded O by O Ministry O of O Science O ICT O and O Future O Planning O Ministry O of O Trade O Industry O O Energy O and O Ministry O of O Health O O Welfare O 2016 O Research O Grant O from O Kangwon B-ORG National I-ORG University I-ORG No. O 520160427 B-AWARD and O the B-ORG Leaders I-ORG INdustry-university I-ORG Cooperation I-ORG Project I-ORG supported O by O the O Ministry O of O Education O Science O O Technology O MEST O No. O C1012957-01-01 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O SAF2007/60058 O SAF2008/00031 O SAF2011/22555 O and O SAF2014-51795-R B-AWARD from O Ministerio B-ORG de I-ORG Ciencia I-ORG e I-ORG Innovación I-ORG to O MB, O Comunidad B-ORG de I-ORG Madrid I-ORG S2010/BMD-2423 O and O CIBER B-ORG de I-ORG Diabetes I-ORG y I-ORG Enfermedades I-ORG Metabólicas I-ORG Asociadas I-ORG CIBERDEM O ISCIII O Spain O to O MB, O Spain O This O work O was O supported O by O grants O from O the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 863 O Program O 2014AA020610 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81771489 O Beijing B-ORG Municipal I-ORG Science I-ORG I-ORG Technology I-ORG Commission I-ORG Z171100000117002 O and O China B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2017YFC0908300 O Research O for O this O study O was O funded O by O the O Economic B-ORG and I-ORG Social I-ORG Research I-ORG Council I-ORG PTA-031-2005-00036 O the O European B-ORG Research I-ORG Council I-ORG 340510 O and O the O Wellcome B-ORG Trust I-ORG 203376/Z/16/Z O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81673147 B-AWARD 81372985 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 2242017K40035 B-AWARD and O the O General B-ORG Program I-ORG of I-ORG University I-ORG Science I-ORG Research I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O 17KJB190001 B-AWARD This O research O was O supported O by O the B-ORG Zhejiang I-ORG Public I-ORG Welfare I-ORG Technology I-ORG Application I-ORG Research I-ORG Program I-ORG LGF20H260009 O LGF20H040005 B-AWARD the B-ORG Zhejiang I-ORG Medical I-ORG and I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG 2022KY1152 O and O the B-ORG Ningbo I-ORG Nonprofit I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 2021S132 O This O clinical O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81270980 O 81570889 B-AWARD and O 91546101 B-AWARD the B-ORG Guangdong I-ORG Technology I-ORG Programs I-ORG 2009B080701017 O the B-ORG Guangdong I-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG of I-ORG China I-ORG 2014A030306030 O and O Collaboration B-ORG Funds I-ORG of I-ORG Clinical I-ORG Research I-ORG Center I-ORG of I-ORG Zhongshan I-ORG Ophthalmic I-ORG Center I-ORG Sun I-ORG Yat-sen I-ORG University I-ORG 3030901011044 O 3031101023 B-AWARD The O sponsors O of O the O study O played O no O role O in O the O study O protocol O design O data O collection O data O analysis O data O interpretation O manuscript O preparation O or O the O decision O to O submit O the O manuscript O for O publication O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81671818 O Hubei B-ORG Province I-ORG health I-ORG and I-ORG family I-ORG planning I-ORG scientific I-ORG research I-ORG project I-ORG China I-ORG WJ2019Z010 O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Wuhan I-ORG China I-ORG 2017060201010148 O and O Medical B-ORG Science I-ORG Advancement I-ORG Program I-ORG Basic I-ORG Medical I-ORG Science I-ORG of I-ORG Wuhan I-ORG University I-ORG China I-ORG Grant O No. O TFJC20 B-AWARD 18003 O This O work O was O supported O by O CNPq B-ORG #471382/2011-6 O and O FAPESP B-ORG #2011/02746-4 O 2013/01029-2 I-AWARD 2013/02549-0 I-AWARD and I-AWARD 2018/04250-5 O for O experiments O conducted O in O Brazil O and O by O ERC B-ORG #322742 O for O experiments O conducted O in O Finland O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O primarily O supported O by O the O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG XDB03030401 O and O the O National B-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG of I-ORG China I-ORG 41401070 O and O partly O supported O the O international O postdoctoral O exchange O fellowship O program O to O Jianshuang O Wu O from O the O Office B-ORG of I-ORG China I-ORG Postdoctoral I-ORG Council I-ORG No. O 20140041 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O research O grants O from O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Council I-ORG MOST O 109-2320-B-182-010-MY3 O Taipei O National B-ORG Health I-ORG Research I-ORG Institute I-ORG NHRI-EX103-10322SC O NHRI-EX104-10322SC B-AWARD NHRI-EX105-10322SC B-AWARD and O NHRI-EX106-10322SC B-AWARD Miaoli O and O Chang B-ORG Gung I-ORG Memorial I-ORG Hospital I-ORG CMRPD1K0371 O CMRPD1L0301 B-AWARD and O CMRPD1M0671 B-AWARD Taoyuan O Taiwan O This O work O was O supported O by O the O Scientific B-ORG and I-ORG Technological I-ORG Innovation I-ORG Project I-ORG of I-ORG China I-ORG Medical I-ORG Sciences I-ORG CI2021A04904 O CI2021A04907 B-AWARD and O CI2021B015 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81830111 B-AWARD and O 81774201 B-AWARD and O the O Intergovernmental B-ORG Cooperation I-ORG in I-ORG International I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG No. O 2022YFE0119300 B-AWARD This O study O was O supported O by O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Grant O No. O XDA2006030201 B-AWARD and O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Desert I-ORG and I-ORG Oasis I-ORG Ecology I-ORG #Y471163 O Chi O Zhang O is O supported O by O the O Taishan B-ORG Scholars I-ORG Program I-ORG of I-ORG Shandong I-ORG China I-ORG Grant O No. O ts201712071 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National O Key O R&D O Program O of O the O Thirteenth O 2017YFC0504505 O China B-ORG Scholarship I-ORG Council I-ORG 201606090065 O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG 1105007002 O Innovative B-ORG Venture I-ORG Technology I-ORG Investment I-ORG Project I-ORG of I-ORG Hunan I-ORG Province I-ORG 2018GK5028 O and O Key O R&D O Program O of O Hunan O Province O 2018WK2111 O are O gratefully O acknowledged O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No.2018YFD0100600 O Program B-ORG for I-ORG Science I-ORG Technology I-ORG Innovation I-ORG Talents I-ORG in I-ORG Universities I-ORG of I-ORG Henan I-ORG Province I-ORG No.19HASTIT014 O and O Research B-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Henan I-ORG Province I-ORG of I-ORG China I-ORG No. O 182102110337 O This O study O is O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 82271990 B-AWARD Shenkang B-ORG 3-year I-ORG project I-ORG of I-ORG clinical I-ORG innovation I-ORG Grant O No. O SHDC2022CRD016 B-AWARD Shanghai B-ORG Committee I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Grant O No. O 21ZR1452200 B-AWARD and O Shanghai B-ORG Health I-ORG Commission I-ORG Discipline I-ORG Leader I-ORG Project I-ORG Grant O No. O 2022XD031 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 32160104 B-AWARD the O Project B-ORG of I-ORG Guizhou I-ORG Science I-ORG and I-ORG Technology I-ORG Platform I-ORG and I-ORG Talent I-ORG Team I-ORG No. O QKHZC B-AWARD 2021 I-AWARD general I-AWARD 424 I-AWARD and O QKHZC B-AWARD 2021 I-AWARD general I-AWARD 129 O the O Guizhou B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O QKHJC B-AWARD 2021 I-AWARD general I-AWARD 512 O the O Project B-ORG of I-ORG Key I-ORG Laboratory I-ORG for I-ORG Characteristics I-ORG of I-ORG Colleges I-ORG and I-ORG Universities I-ORG of I-ORG Guizhou I-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG No. O QJHKYZ B-AWARD 2020)018 O This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grants O No. I-AWARD 81570342 I-AWARD and O No. O 81600298 O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grants O No. I-AWARD LY18H020011 I-AWARD and O No. O LY16H020011 O and O Wenzhou B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG China I-ORG grant O No. I-AWARD Y20130270 O The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O manuscript O preparation O This O work O was O supported O by O Project B-ORG of I-ORG Henan I-ORG Educational I-ORG Department I-ORG of I-ORG China I-ORG 18A180015 O 18A210017 B-AWARD Sci-Tech B-ORG Project I-ORG of I-ORG Henan I-ORG Province I-ORG China I-ORG 182102110278 O and O Sci-Tech O Innovation O Fund O of O Henan O Agricultural O University O KJCX2019A16 O And O Open B-ORG Project I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Crop I-ORG Stress I-ORG Biology I-ORG for I-ORG Arid I-ORG Areas I-ORG NWAFU I-ORG of I-ORG China I-ORG CSBAAKF2018007 O The O Youth O Fund O of O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81100813 O Natural B-ORG Science I-ORG Found I-ORG for I-ORG Colleges I-ORG and I-ORG Universities I-ORG of I-ORG Jiangsu I-ORG Education I-ORG Department I-ORG 11KJB320018 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2012M510189 O The O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Shandong I-ORG Educational I-ORG Commission I-ORG J14LL02 O the O Youth B-ORG Fund I-ORG of I-ORG Affiliated I-ORG Hospital I-ORG of I-ORG Binzhou I-ORG Medical I-ORG College I-ORG 2013QNKYJJ09 O and O the O Doctor O Startup O Fund O Program O funded O by O the O Affiliated O Hospital O of O Binzhou O Medical O College O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61904073 B-AWARD Spring B-ORG City I-ORG Plan-Special I-ORG Program I-ORG for I-ORG Young I-ORG Talents I-ORG ZX20210014 O Yunnan B-ORG Talents I-ORG Support I-ORG Plan I-ORG for I-ORG Yong I-ORG Talents I-ORG Yunnan I-ORG Local I-ORG Colleges I-ORG Applied I-ORG Basic I-ORG Research I-ORG Projects I-ORG 202101BA070001-138 O Scientific B-ORG Research I-ORG Fund I-ORG of I-ORG Yunnan I-ORG Education I-ORG Department I-ORG 2022Y728 O and O Scientific O Research O Fund O of O Yunnan O Education O Department O 2023Y0891 O This O study O was O supported O by O grants O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 91332201 O 81071019 O 81500907 O 31471027 O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG 13JC1401501 O and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG Foundation I-ORG of I-ORG China I-ORG 2016YFC1306403 O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSF O 81571029 O 81873778 B-AWARD 81501097 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG Shanghai O Natural O Science O Foundation O 19ZR1432500 O This O study O was O also O supported O by O grants O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2016YFC1306505 O and O the O Shanghai B-ORG Municipal I-ORG Education I-ORG Commission-Basic I-ORG Key I-ORG Project I-ORG 18JC1420300 O This O study O was O funded O by O the O following O grants O Clinical B-ORG Research I-ORG Hospital I-ORG Program I-ORG from I-ORG the I-ORG French I-ORG Ministry I-ORG of I-ORG Health I-ORG PHRC O GMAJ B-AWARD 2008/067 O to O DC; O Funding O from O the O French O Ministry O of O Health O to O the O National O Reference O Centre O for O Young O Alzheimer O Disease O CNR-MAJ O to O DH; O Joint O Program O for O Neurodegenerative O Disease O Research O from O the O European B-ORG Union I-ORG JPND O PERADES I-AWARD ANR-13-JPRF-0001-04 O to O DC. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China O grant O 2014AA021102 B-AWARD http://program.most.gov.cn O to O QC; O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O 91339106 B-AWARD 81422006 I-AWARD http://www.nsfc.gov.cn O to O QC O and O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation O grant O 2016M591024 B-AWARD http://www.chinapostdoctor.org.cn O to O YZ. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 81573456 B-AWARD 81773766 B-AWARD and O 81872892 B-AWARD the O Postgraduate B-ORG Research I-ORG I-ORG Practice I-ORG Innovation I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG NO. O KYCX17_0690 B-AWARD the O “Double O First-Class” O University O project O no. O CPU2018GY38 O and O the B-ORG Research I-ORG Team I-ORG of I-ORG Novel I-ORG PROTACs I-ORG at I-ORG CPU I-ORG no. O 3151830069 B-AWARD This O study O was O funded O by O Public B-ORG Health I-ORG Personnel I-ORG Training I-ORG Program I-ORG of I-ORG China I-ORG and I-ORG the I-ORG United I-ORG States-Fogarty I-ORG Foundation I-ORG and O through O a O research O grant O TW005741-07 O LZ O the O Foundation B-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Family I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG grant O numbers O Grant O No. O 20134289 B-AWARD LZ O Public B-ORG Health I-ORG Key I-ORG Discipline I-ORG Construction I-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Family I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Environmental I-ORG and I-ORG Occupational I-ORG Health I-ORG Grant O No. O 15GWZK0201 B-AWARD XJ O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Grants B-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81671164 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG of I-ORG China I-ORG No. O 13KJA310005 B-AWARD and O A B-ORG Project I-ORG Funded I-ORG by I-ORG the I-ORG Priority I-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institution I-ORG No. O 201510313014Z B-AWARD This O work O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 52001039 B-AWARD National O Natural O Science O Foundation O of O China O under O Grand O No. O 52171310 B-AWARD Shandong B-ORG Natural I-ORG Science I-ORG Foundation I-ORG in I-ORG China I-ORG No. O ZR2019LZH005 B-AWARD Research O fund O from O Science B-ORG and I-ORG Technology I-ORG on I-ORG Underwater I-ORG Vehicle I-ORG Technology I-ORG Laboratory I-ORG No. O 2021JCJQ-SYSJJ-LB06903 B-AWARD University B-ORG Innovation I-ORG Team I-ORG Project I-ORG of I-ORG Jinan I-ORG No. O 2019GXRC015 B-AWARD Science B-ORG and I-ORG technology I-ORG improvement I-ORG project I-ORG for I-ORG small I-ORG and I-ORG medium-sized I-ORG enterprises I-ORG in I-ORG Shandong I-ORG Province I-ORG No. O 2021TSGC1012 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U1604234 O Henan B-ORG Provincial I-ORG Special I-ORG Fund I-ORG for I-ORG the I-ORG Construction I-ORG of I-ORG Modern I-ORG Agricultural I-ORG Industrial I-ORG Technology I-ORG Systems O HARS-22-02-G5 O and O the O Natural B-ORG Science I-ORG Innovation I-ORG Fund I-ORG Support I-ORG Program I-ORG of I-ORG Henan I-ORG University I-ORG of I-ORG Technology I-ORG 2021ZKCJ12 O This O research O was O funded O by O the O President's O Emergency O Plan O for O AIDS O Relief O PEPFAR O through O the O National B-ORG Institute I-ORG of I-ORG Child I-ORG Health I-ORG and I-ORG Human I-ORG Development I-ORG NICHD O grant O number O 1R01HD074558(https://www.nichd.nih.gov/grants-funding/Pages/default.aspx B-AWARD Drs O Mellins O and O Remien O were O also O supported O by O the O HIV B-ORG Center I-ORG for I-ORG Clinical I-ORG and I-ORG Behavioral I-ORG Studies I-ORG P30-MH43520 O http://www.cumc.columbia.edu/publications/press_releases/hiv_center.html O and O Annibale O Cois O was O supported O by O the O Harry B-ORG Crossley I-ORG Foundation I-ORG Harry O Crossley I-AWARD Senior I-AWARD Clinical I-AWARD Fellowship I-AWARD 2015-2016 O Tamsin O Phillips O is O supported O by O a O bursary O from O the O South O African O Centre O for O Epidemiological O Modelling O and O Analysis O Additional O funding O comes O from O the O Elizabeth O Glaser O Pediatric O AIDS O Foundation O http://www.pedaids.org O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Nível I-ORG Superior I-ORG CAPES O Finance O Code O 001 B-AWARD Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq O grant O No. O 307432/2017-3 B-AWARD 307505/2021-9 B-AWARD 420097/2021-0 B-AWARD 402387/2020-1 B-AWARD 401256/2020-0 B-AWARD and O Instituto B-ORG Nacional I-ORG de I-ORG Ciência I-ORG e I-ORG Tecnologia I-ORG de I-ORG Bioanalítica I-ORG INCT O FAPESP O Grant O No O 2014/50867-3 B-AWARD and O CNPq O grant O No. O 465389/2014-7 B-AWARD This O study O was O supported O by O the O National O Key O R&D O Program O of O China O 2019YFC1709701 O the O National B-ORG Natural I-ORG Foundation I-ORG for I-ORG Excellent I-ORG Youth I-ORG Fund I-ORG 81722050 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81973962 O 81871330 B-AWARD and O the O First-Class B-ORG Disciplines I-ORG Development I-ORG supported I-ORG by I-ORG Chengdu I-ORG University I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG CZYJC1901 O The O authors O would O like O to O thank O the O following O grant O sources O Army B-ORG Research I-ORG Office I-ORG Staff B-AWARD Research I-AWARD Grant O to O V.P O and O L.M O NSF O DMS O Math O Biology O and O CBET O Fluid O Dynamics O 1022802 B-AWARD to O L.M O and O Simons B-ORG Foundation I-ORG 585322,WCS O to O C.S O D.K O and O T.D O Thomas O Dombroski O acknowledge O the O National B-ORG Science I-ORG Foundation O Grant O Award O No. O DMR-1753148 O Authors O at O the O University O of O Puerto O Rico O at O Mayaguez O were O supported O in O part O by O a O National B-ORG Science I-ORG Foundation I-ORG award O 1432092 O Authors O at O the O Theodosius O Dobzhansky O Center O for O Genome O Bioinformatics O were O supported O by O a O Russian B-ORG Ministry I-ORG of I-ORG Science I-ORG mega-grant O 11.G34.31.0068 O and O a O St. B-ORG Petersburg I-ORG State I-ORG University I-ORG grant O 1.50.1623.2013 O This O research O was O funded O by O the O Slovak B-ORG Research I-ORG and I-ORG Development I-ORG Agency I-ORG APVV-20-0272 O and O APPV B-AWARD 17-0300 O and O by O the O Slovak B-ORG Scientific I-ORG Grant I-ORG Agency I-ORG VEGA O 2/0137/18 I-AWARD and O 2/0130/20 B-AWARD We O would O like O to O acknowledge O the O support O received O from O the O Ministry B-ORG of I-ORG Health I-ORG of I-ORG the I-ORG Slovak I-ORG Republic I-ORG under O project O registration O number O 2019/68-CHÚSAV-1 B-AWARD This O publication O was O created O with O the O support O of O the O Operational B-ORG Programme I-ORG Integrated I-ORG Infrastructure I-ORG for O the O project O of O Center O for O Biomedical O Research-BIOMEDIRES-II O stage O ITMS O 313011W428 B-AWARD co-financed O by O the O European O Regional O Development O Fund O P.K O thanks O that O this O publication O was O jointly O supported O by O Qatar B-ORG University I-ORG grant O O QUCG-CAM-22/23-504 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31772580 O and O 31472078 B-AWARD the O Fund O Project O of O Gansu O Agricultural O University O GSAU-ZL-2015-027 O the O Genetically B-ORG Modified I-ORG Organisms I-ORG Breeding I-ORG Major I-ORG Program I-ORG of I-ORG China I-ORG 2016ZX08009-003-006 O and O 2016ZX08010-005-003 B-AWARD the O Earmarked B-ORG Fund I-ORG for I-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-38 O the O Central O Public-Interest O Scientific O Institution O Basal O Research O Fund O 2018-YWF-YB-1 O Y2017JC24 B-AWARD 2017ywf-zd-13 B-AWARD the O Agricultural O Science O and O Technology O Innovation O Program O of O China O ASTIP-IAS13 O CAAS-XTCX2016010-01-03 B-AWARD CAAS-XTCX2016010-03-03 B-AWARD CAAS-XTCX2016011-02-02 B-AWARD the O China O Agricultural O Scientific O Research O Outstanding O Talents O and O Their O Innovative O Teams O Program O the O China O High-level O Talents O Special O Support O Plan O Scientific O and O Technological O Innovation O Leading O Talents O Program O W02020274 O and O the O Tianjin O Agricultural O Science O and O Technology O Achievements O Transformation O and O Popularization O Program O 201704020 O The O APC O was O funded O by O the O National O Natural O Science O Foundation O of O China O 31772580 O This O study O was O funded O by O the O project O e-Flavor O grant O number O POCI-01-0247-FEDER-049337 B-AWARD funded O by O the O FEEI B-ORG supported O by O the O FEDER O through O the O Competitiveness O and O Internationalization O Operational O Program O It O was O also O funded O by O the O CQ-VR B-ORG grant O number O UIDB/00616/2020 B-AWARD and O UIDP/00616/2020 B-AWARD and O by O the O CEMAT/IST-ID B-ORG grant O number O UIDB/04621/2020 B-AWARD and O UIDP/04621/2020 B-AWARD FCT—Portugal O and O COMPETE O Maria O João O SANTOS O is O also O funded O by O the O “e-Flavor” B-ORG R&D I-ORG project O operation O POCI-01-0247-FEDER-049337 O grant O number O BI/UTAD/31/2021 B-AWARD This O project O was O supported O by O the O National B-ORG Key I-ORG Plan I-ORG for I-ORG Scientific I-ORG Research I-ORG and I-ORG Development I-ORG of I-ORG China I-ORG Grant O no. O 2016YFD0500303 B-AWARD the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG Grant O no. O 2018ZX10101004 B-AWARD and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG General I-ORG Program I-ORG Grant O no. O 81871687 B-AWARD Wellcome B-ORG Trust I-ORG 100401/Z/12/Z O to O M.D O European B-ORG Research I-ORG Council I-ORG 681299 O to O F.M.-H O Spanish O Ministry B-ORG of I-ORG Economy I-ORG and I-ORG Competitiveness I-ORG BFU2017-83794-P O AEI/FEDER O UE O to O F.M.-H O Comunidad B-ORG de I-ORG Madrid I-ORG Tec4Bio O S2018/NMT-4443 O to O F.M.-H O NanoBioCancer B-ORG Y2018/BIO-4747 O to O F.M.-H O Funding O for O open O access O charge O Wellcome O Trust O 100401/Z/12/Z O Authors O acknowledge O financial O support O from O the O National O Key O R&D O Program O of O China O No.2018YFB1105900 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG No. O ZR2018MEE018 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2018M630772 O the O Shenzhen B-ORG science I-ORG and I-ORG technology I-ORG project I-ORG JCYJ20170818103826176 O and O the O Young B-ORG Scholars I-ORG Program I-ORG of I-ORG Shandong I-ORG University I-ORG Weihai I-ORG No. O 2015WHWLJH03 O This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2016YFD0500707 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31872489 O and O Modern B-ORG Agro-Industry I-ORG Technology I-ORG Research I-ORG System I-ORG CARS-36 O This O work O was O supported O by O the O Brazilian O agencies O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG 2447/09 O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG 303227/2013-3 O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG Minas I-ORG Gerais I-ORG CBB O I-AWARD APQ-01542-13 I-AWARD and O RED-00007-14 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31770387 O 31700271 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Jiangsu I-ORG Province I-ORG BK20170617 O and O the O Jiangsu B-ORG Provincial I-ORG Public I-ORG Institutions I-ORG Program I-ORG for I-ORG Research I-ORG Conditions I-ORG and I-ORG Building I-ORG Capacity I-ORG BM2015019 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG 16ZR1431100 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Medical B-ORG Research I-ORG Council I-ORG MRC_MC_UU_12012/4 O the O British B-ORG Heart I-ORG Foundation I-ORG FS/12/64/30001 O to O E.L O PG/14/20/30769 B-AWARD and O RG/17/12/33167 B-AWARD and O the O São B-ORG Paulo I-ORG Research I-ORG Foundation I-ORG 2017/03525-8 O to O J.A.F O The O research O was O funded O by O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2019B020212001 B-AWARD Zhejiang B-ORG Basic I-ORG Public I-ORG Welfare I-ORG Research I-ORG Project I-ORG LGN19C200003 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC1603600 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31871884 B-AWARD This O research O was O partially O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31260255 O 31360147 B-AWARD and O 31660384 B-AWARD the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Province I-ORG China I-ORG 20151BAB204008 O and O 20171BAB204021 B-AWARD and O the B-ORG Major I-ORG Projects I-ORG in I-ORG Jiangxi I-ORG Province I-ORG 20161ACF60022 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51731003 B-AWARD The O Key O Research O and O Development O Program O of O Shanxi O Province O No. O 201803D421046 O “131” O Leading O Talents O Project O of O Higher O Education O Institutions O in O Shanxi O 2015 O Overseas O Students O Science O and O Technology O Activities O Project O Merit O Funding O 2016 O Shanxi B-ORG Scholarship I-ORG Council I-ORG of I-ORG China I-ORG No. O 2017-085 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Provincial I-ORG No. O 2018A030313246 B-AWARD and O the O Fund O for O Shanxi O Key O Subjects O Construction O This O work O was O supported O by O Fundação B-ORG de I-ORG Amparo I-ORG a I-ORG Pesquisa I-ORG do I-ORG Distrito I-ORG Federal/Conselho I-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Cientifico I-ORG FAP-DF/CNPq/Pronex O 193000569/2009 B-AWARD and O National O Institute O of O Health O National B-ORG Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases I-ORG NIH/NIAID O K22 O AI104801 B-AWARD RMZO O was O supported O in O part O by O CNPq O 304976/2013-0 O and O FAPERJ B-ORG E-26/103.157/2011 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2017YFA0402903 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 51627901 B-AWARD U1932216 B-AWARD 12004386 B-AWARD Maintenance B-ORG and I-ORG Renovation I-ORG Project I-ORG for I-ORG CAS I-ORG Major I-ORG Scientific I-ORG and I-ORG Technological I-ORG Infrastructure I-ORG Grant O No. O DSS-WXGZ-2019-0011 B-AWARD Scientific B-ORG Instrument I-ORG Developing I-ORG Project I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Grant O No. O YJKYYQ20190014 B-AWARD and O Hefei B-ORG Science I-ORG Center I-ORG CAS I-ORG Grant O No. O 2020HSC-UE014 B-AWARD 2021HSC-UE010 B-AWARD Financial O support O from O the O Hebei B-ORG Soft I-ORG Science I-ORG Foundation I-ORG grant O number O 19456106D B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG grant O number O 2017M621047 B-AWARD 14th B-ORG Five-Year I-ORG Plan I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Development I-ORG and I-ORG Reform I-ORG Commission I-ORG grant O number O DRC14-21 B-AWARD and O Hebei B-ORG Social I-ORG Science I-ORG Foundation I-ORG grant O number O HB18GL034 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O sponsored O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81770635 O LHH O and O 81470883 B-AWARD LHH O Shanghai B-ORG Rising-Star I-ORG Program I-ORG Grant O No. B-AWARD 17QA1405500 I-AWARD LHH O Special B-ORG Foundation I-ORG for I-ORG Wisdom I-ORG Medicine I-ORG of I-ORG Shanghai I-ORG Grant O No. B-AWARD 2018ZHYL0229 I-AWARD LHH O and O Shanghai B-ORG Youth I-ORG Top-notch I-ORG Talent I-ORG Program I-ORG Grant O No. B-AWARD HZW2016FZ67 I-AWARD LHH O Agentschap B-ORG Innoveren I-ORG en I-ORG Ondernemen I-ORG VLAIO O 150466 B-AWARD OSA O Agentschap B-ORG voor I-ORG Innovatie I-ORG door I-ORG Wetenschap I-ORG en I-ORG Technologie I-ORG IWT O O&O O HBC O 2016 O 0184 B-AWARD eWatch O imec B-ORG funds I-ORG 2017 O European B-ORG Research I-ORG Council O The O research O leading O to O these O results O has O received O funding O from O the O European O Research O Council O under O the O European O Union’s O Seventh O Framework O Programme O FP7/2007–2013)/ERC O Advanced O Grant O BIOTENSORS O nr O 339804 B-AWARD This O paper O reflects O only O the O authors’ O views O and O the O Union O is O not O liable O for O any O use O that O may O be O made O of O the O contained O information O Carolina O Varon O is O a O postdoctoral O fellow O of O the O Research O Foundation-Flanders O FWO O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 31960190 B-AWARD 82160688 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG No. O 20192BAB205117 B-AWARD and O the O Innovation B-ORG Team I-ORG Foundation I-ORG of I-ORG Gannan I-ORG Medical I-ORG University I-ORG Nos O TD201705 B-AWARD TD2021JC06 B-AWARD This O research O was O funded O by O the O Guangzhou B-ORG Key I-ORG R&D I-ORG Plan I-ORG 202103000031 O the B-ORG open I-ORG project I-ORG of I-ORG the I-ORG Guangdong I-ORG University I-ORG Key I-ORG Laboratory I-ORG for I-ORG Sustainable I-ORG Control I-ORG of I-ORG Fruit I-ORG and I-ORG Vegetable I-ORG Diseases I-ORG and I-ORG Pests I-ORG KA21031C5-04 O the O open O project O of O the O Guangdong O University O Key O Laboratory O for O Sustainable O Control O of O Fruit O and O Vegetable O Diseases O and O Pests O KA21031C5-01 O and O the O regional O joint O fund O of O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Fund—Youth I-ORG Fund I-ORG project I-ORG 2022A1515110982 O This O work O was O supported O by O the O U.S B-ORG Environmental I-ORG Protection I-ORG Agency I-ORG No. O RD-83543301 B-AWARD and O the O National B-ORG Institute I-ORG of I-ORG Environmental I-ORG Health I-ORG Sciences I-ORG P01ES022841 O R00ES023846 B-AWARD and O the O National B-ORG Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases I-ORG K08AI141728 O to O SLG O These O funding O sources O had O no O involvement O in O the O conduct O of O the O research O or O preparation O of O this O article O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31472180 O 31572507 B-AWARD and O 31772728 B-AWARD the O earmarked O fund O for O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-43 O and O Chinese B-ORG Ministry I-ORG of I-ORG Agriculture I-ORG 948 O Program O 2015-Z31 B-AWARD The O funding O bodies O did O not O have O any O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O funded O by O the B-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG CAAS-ASTIP O CAAS-XTCX2016017005 B-AWARD the B-ORG Earmarked I-ORG Fund I-ORG for I-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-28 O the B-ORG Central I-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG 1610192017709 O and O the B-ORG Science-Technology I-ORG Project I-ORG of I-ORG Henan I-ORG Province I-ORG 172102110244 O This O study O was O supported O by O grants O from O National B-ORG Taiwan I-ORG University I-ORG Hospital I-ORG Yun-Lin I-ORG Branch I-ORG grant O number O NTUHYL107.X016 B-AWARD to O J-TL O from O the B-ORG Taiwan I-ORG Centers I-ORG for I-ORG Disease I-ORG Control I-ORG the I-ORG Ministry I-ORG of I-ORG Health I-ORG and I-ORG Welfare O Taiwan O grant O number O MOHW B-AWARD 106-CDC-C-114-000117 O to O L-YC O and O the B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Taiwan I-ORG grant O numbers O MOST B-AWARD 108-2321-B-002-016 I-AWARD and I-AWARD 108-3017-F-002-004 O to O L-YC O This O work O was O also O financially O supported O by O the O ‘Center O of O Precision O Medicine’ O from O The O Featured O Areas O Research O Center O Program O within O the O framework O of O the O Higher O Education O Sprout O Project O by O the B-ORG Ministry I-ORG of I-ORG Education I-ORG NTU-108L901401 O to O L-MH O The O funders O had O no O role O in O the O conduct O of O the O study O or O the O preparation O of O the O manuscript O This O work O was O financially O supported O by O The B-ORG National I-ORG Natural I-ORG Science I-ORG Funds I-ORG of I-ORG China I-ORG 81803372 O Key B-ORG Laboratory I-ORG of I-ORG Neuropsychiatric I-ORG Drug I-ORG Research I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2019E10021 O and O Health B-ORG Commission I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2019RC141 O and O WJK-ZJ-1918 B-AWARD All O funding O bodies O are O gratefully O acknowledged O RESIDE O was O funded O by O grants O from O the O Western O Australian O Health O Promotion O Foundation O Healthway O #11828 O and O the O Australian B-ORG Research I-ORG Council I-ORG ARC O #LP0455453 O and O supported O by O an O Australian O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG NHMRC O Capacity O Building O Grant O #458688 O The O first O author O was O supported O by O a O Healthway O Research O Fellowship O #32992 O and O an O NHMRC O CRE O in O Healthy O Liveable O Communities O #1061404 O SF O is O supported O by O an O ARC O Discovery O Early O Career O Researcher O Award O DE160100140 O BGC O is O supported O by O an O NHMRC O Senior O Principal O Research O Fellow O Award O #1107672 O This O work O was O supported O by O funding O from O Quality B-ORG standard I-ORG system I-ORG construction I-ORG for I-ORG the I-ORG whole I-ORG industry I-ORG chain I-ORG of I-ORG Chinese I-ORG medicinal I-ORG detection I-ORG pieces I-ORG from O Guangdong O Provincial O Drug O Administration O of O China O 002009/2019KT1261/2020ZDB25 O and O supported O by O the B-ORG special I-ORG foundation I-ORG of I-ORG Guangzhou I-ORG Key I-ORG Laboratory I-ORG No. O 202002010004 B-AWARD Project O for O Automatic B-ORG Analyzer I-ORG of I-ORG DNA I-ORG barcodes I-ORG based I-ORG on I-ORG Sanger I-ORG Sequencing I-ORG and I-ORG DNA I-ORG barcodes I-ORG database I-ORG construction I-ORG for I-ORG medicinal I-ORG plants I-ORG YN2019QJ05 O The O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51622509 O the B-ORG Joint I-ORG Fund I-ORG for I-ORG the I-ORG Equipment I-ORG Pre-research I-ORG of I-ORG Space I-ORG Science I-ORG and I-ORG Technology I-ORG 6141B06240205 O the B-ORG 111 I-ORG Project I-ORG B13044 O and O the B-ORG Innovation I-ORG Foundation I-ORG for I-ORG Doctor I-ORG Dissertation I-ORG of I-ORG Northwestern I-ORG Polytechnical I-ORG University I-ORG CX201830 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31672401 O Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG ZR2014CM029 O a B-ORG project I-ORG of I-ORG the I-ORG Shandong I-ORG Province I-ORG Higher I-ORG Educational I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG China I-ORG J14LF07 O the O Shandong B-ORG Provincial I-ORG Modern I-ORG Agriculture I-ORG Industry I-ORG Technology I-ORG System I-ORG SDAIT-10 O and O funds B-ORG of I-ORG the I-ORG Shandong I-ORG “Double I-ORG Tops” I-ORG Program I-ORG SYL2017YSTD12 O The O funding O body O did O not O exert O influence O on O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20140685 O the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2012AA101401-1 O 2013AA065601 O and O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31401771 O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81672872 O No. O 81272340 O and O No. O 81472386 O to O C.Q O No. O 81572901 O to O B.H O No. O 81572848 O to O L.G O No. O 81402248 O to O D.L O No. O 81372572 B-AWARD and O No. O 81572406 B-AWARD to O J.Y O the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 863 I-ORG Program I-ORG No. O 2012AA02A501 B-AWARD to O C.Q O the B-ORG Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG No. O 2014B020212017 O No. O 2014B050504004 B-AWARD and O No. O 2015B050501005 B-AWARD to O C.Q O and O No. O 2014A020209024 B-AWARD to O B.H O and O the O Provincial B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG China I-ORG No. O 2016A030311011 B-AWARD to O C.Q O This O work O was O supported O by O a O grant O from O the O Key B-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 3163000269 B-AWARD Modern B-ORG Agricultural I-ORG Industry I-ORG Technology I-ORG System I-ORG grant O no. O CARS-35 B-AWARD Major B-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG of I-ORG Zhejiang I-ORG Province I-ORG grant O no. O 2015C02022 B-AWARD This O work O was O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG IOS-0951086 O to O NAA O IOS-0951061 B-AWARD to O CYH O National B-ORG Institutes I-ORG of I-ORG Health I-ORG F32 O GM78875-1A O to O NAA O 1F32GM083661-01 B-AWARD and O 1R15GM097714-01 B-AWARD to O JEG O Army O Research O Office O W911NF-06-1-0455 O and O W911NF-11-1-0299 O to O CYH O and O Washington O and O Lee O University O through O Lenfest O Summer O Fellowships O to O NAA O and O Summer O Research O Scholarships O to O JVH O and O AKL O ERB O was O supported O in O part O by O a O grant O to O Washington O and O Lee O University O from O the O Howard B-ORG Hughes I-ORG Medical I-ORG Institute I-ORG through O the O Precollege O and O Undergraduate O Science O Education O Program O 52007570 O The O study O was O supported O by O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG grant O no. O 2013CB956701 B-AWARD by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0502602 O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 31070365 B-AWARD and O by O the B-ORG Project I-ORG on I-ORG Social I-ORG Development I-ORG of I-ORG Guizhou I-ORG Province I-ORG SY[2010]3043 O and O by O the B-ORG Research I-ORG Foundation I-ORG for I-ORG Advanced I-ORG Talents I-ORG of I-ORG Anqing I-ORG Normal I-ORG University I-ORG 044-140001000032 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG – O 81230016 B-AWARD Financial B-ORG support I-ORG was I-ORG provided I-ORG by I-ORG the I-ORG Chinese I-ORG Ministry I-ORG of I-ORG Health I-ORG MOH I-ORG the I-ORG United I-ORG Nations I-ORG Children’s I-ORG Fund I-ORG UNICEF I-ORG O YH001 B-AWARD Project B-ORG of I-ORG birth I-ORG defect I-ORG control I-ORG and I-ORG prevention I-ORG in I-ORG Shaanxi I-ORG O Sxwsjswzfcght2016-013 B-AWARD This O research O was O supported O by O a B-ORG basic I-ORG research I-ORG program I-ORG of I-ORG project I-ORG 973 I-ORG by I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2011CB013304 O and O by O Grants O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81571184 B-AWARD 81070990 B-AWARD 30670719 B-AWARD 30500525 B-AWARD the B-ORG Shanghai I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG Nos O 15140902100 B-AWARD 10QH1401700 B-AWARD 09140901300 B-AWARD and O the B-ORG Shanghai I-ORG Municipal I-ORG Education I-ORG Commission I-ORG No. O 09SG20 B-AWARD This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 81471228 O 81873759 B-AWARD 81701186 B-AWARD the O Hebei B-ORG Postgraduate I-ORG Innovation I-ORG project I-ORG CXZZBS2017117 O the O Hebei B-ORG critical I-ORG medical I-ORG science I-ORG project I-ORG 20150212 O This O work O was O supported O by O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG R01 B-AWARD GM115188 O Dr. O Kim O Orth O Welch B-ORG Foundation I-ORG I-1561 B-AWARD Dr. O Kim O Orth O Once B-ORG Upon I-ORG A I-ORG Time I-ORG Foundation I-ORG 0000 B-AWARD Dr. O Kim O Orth O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O National B-ORG High-tech I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG 863 O Project O 2014AA021304 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31400058 O 31300087 B-AWARD 31400078 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20130139 O BK20130131 B-AWARD BK20140151 B-AWARD This O study O was O supported O by O a O pilot O study O award O from O the O University B-ORG of I-ORG Kentucky I-ORG Center I-ORG for I-ORG Clinical I-ORG and I-ORG Translational I-ORG Sciences I-ORG UL1TR000117 O Additional O support O was O provided O by O the O University B-ORG of I-ORG Kentucky I-ORG Alzheimer’s I-ORG Disease I-ORG Center I-ORG P30 O AG028383 O DCM O was O supported O by O grant O number O K12 B-AWARD DA035150 I-AWARD Building O Interdisciplinary I-ORG Research I-ORG Careers I-ORG in I-ORG Women’s I-ORG Health O from O the O National O Institutes O of O Health O the O Office O of O Women’s O Health O Research O and O the O National O Institute O on O Drug O Abuse O This O research O was O funded O by O the O European B-ORG Research I-ORG Council I-ORG grant O award O no. O 335925 B-AWARD The O Epistemology O of O Data-Intensive O Science O the O Leverhulme B-ORG Trust I-ORG grant O no. O RPG-2013-153 B-AWARD and O the O Australian B-ORG Research I-ORG Council O Discovery O Project O No. O DP160102989 B-AWARD This O research O was O funded O by O Ricerca B-ORG Finalizzata I-ORG 2016 O RF-2016-02361941 B-AWARD MIUR O PON O “Ricerca O e O Innovazione” O PerMedNet O id O project O ARS01_01226-PROGETTI O DI O RICERCA O DI O RILEVANTE O INTERESSE O NAZIONALE O Prot O 2017MYJ5TH B-AWARD European B-ORG Commission’s I-ORG Horizon I-ORG 2020 I-ORG research I-ORG and I-ORG innovation I-ORG program I-ORG No. O 847749 B-AWARD MIUR B-ORG Bando I-ORG PRIN I-ORG 2017 I-ORG cod O 2017MYJ5TH O I.M O and O A.D O would O like O to O acknowledge O financial O support O received O from O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council O part O of O UK O Research O and O Innovation O BB/S00324X/1 O BB/M006298/1 O and O Dunhill B-ORG Medical I-ORG Trust I-ORG AIS2110\33 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81771887 O 81771897 B-AWARD 81471721 O 81471722 B-AWARD 81971586 B-AWARD and O 81901712 O Program B-ORG for I-ORG New I-ORG Century I-ORG Excellent I-ORG Talents I-ORG in I-ORG University I-ORG No: O NCET-13-0386 B-AWARD Program B-ORG for I-ORG Young I-ORG Scholars I-ORG and I-ORG Innovative I-ORG Research I-ORG Team I-ORG in I-ORG Sichuan I-ORG Province I-ORG of I-ORG China I-ORG 2017TD0005 O 1·3·5 B-ORG project I-ORG for I-ORG disciplines I-ORG of I-ORG excellence I-ORG West I-ORG China I-ORG Hospital I-ORG Sichuan I-ORG University I-ORG ZYGD18013 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81601677 O and O 81571892 B-AWARD Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG for I-ORG Academicians I-ORG of I-ORG Chongqing I-ORG cstc2017jcyj-yszxX0007 O and O Medical B-ORG Research I-ORG Funding I-ORG of I-ORG PLA I-ORG 17QNP005 O and O AWS14C003 B-AWARD This O research O was O supported O by O grants O from O the O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG of O Australia O www.nhmrc.gov.au O TPS O PDRJ O GNT1049183 B-AWARD the O End B-ORG Buruli I-ORG ulcer I-ORG Alliance I-ORG JRW O 6032305815 B-AWARD and O the O Millersville B-ORG University I-ORG Faculty B-AWARD grant I-AWARD program I-AWARD JRW O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O The B-ORG Western I-ORG Young I-ORG Scholars I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG 2021-XBQNXZ-015 O the O Outstanding B-ORG Young I-ORG Scientific I-ORG and I-ORG Technological I-ORG Talents I-ORG Training I-ORG Program I-ORG of I-ORG Xinjiang I-ORG Uygur I-ORG Autonomous I-ORG Region I-ORG 2019Q035 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31700289 B-AWARD the O Youth B-ORG Innovation I-ORG Promotion I-ORG Association I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG No. O 2018478 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Xinjiang I-ORG Uygur I-ORG Autonomous I-ORG Region I-ORG 2022D01A354 O This O work O was O supported O by O National B-ORG Key I-ORG Technologies I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG No. O 2018YFD0200707 B-AWARD 2018YFD0800600 B-AWARD Education B-ORG Department I-ORG of I-ORG Sichan I-ORG Province I-ORG No. O 035Z2240 B-AWARD Public B-ORG Welfare I-ORG Industry I-ORG Research I-ORG of I-ORG Fujian I-ORG Province I-ORG No. O 2017R1026-1 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O Key B-ORG Research I-ORG Project I-ORG of I-ORG Soft I-ORG Science I-ORG in I-ORG Zhejiang I-ORG Province I-ORG Project O No. O 2023C25046 B-AWARD Humanities B-ORG and I-ORG Social I-ORG Sciences I-ORG Foundation I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG Project O No. O 22YJAZH153 B-AWARD Zhejiang B-ORG Federation I-ORG of I-ORG Humanities I-ORG and I-ORG Social I-ORG Sciences I-ORG Circles I-ORG Research I-ORG Project I-ORG Project O No. O 2022N95 B-AWARD and O Research B-ORG Center I-ORG for I-ORG Digital I-ORG Economy I-ORG and I-ORG Sustainable I-ORG Development I-ORG of I-ORG Water I-ORG Resources I-ORG Zhejiang I-ORG University I-ORG of I-ORG Water I-ORG Resources I-ORG and I-ORG Electric I-ORG Power I-ORG Project O No. O xrj2022014 B-AWARD The O study O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Gansu I-ORG Province I-ORG 1506RJZA211 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG lzujbky-2016-5 O and O the O National B-ORG Key I-ORG Technology I-ORG Support I-ORG Program I-ORG 2014B O AD14B006 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O is O kindly O supported O by O CONICET B-ORG Funder O Id: O 10.13039/501100002923 O grant O PIP B-AWARD 112-2012-0100471 I-AWARD and O UNS B-ORG Funder O Id: O 10.13039/501100007869 O grants O PGI B-AWARD 24/N042 I-AWARD and I-AWARD PGI I-AWARD 24/ZM17 O We O also O acknowledge O MECD B-ORG VSP I-ORG grant O FPU15/01465 B-AWARD Funder O Id: O 10.13039/501100003176 O and O Banco B-ORG Santander I-ORG for O Funder O Id: O 10.13039/100010784 O VSP O fellowship O AY21/17-D-27 B-AWARD in O the O “Becas O Iberoamerica-Santander O Investigación” O program O The O authors O acknowledge O support O from O Cancer B-ORG Research I-ORG UK I-ORG C30122/A11527 O C30122/A15774 B-AWARD the O Academy B-ORG of I-ORG Medical I-ORG Sciences O CRUK/NIHR O in O England/DoH O for O Scotland O Wales O and O Northern O Ireland O Experimental O Cancer O Medicine O Centre O C10355/A15587 O the O Inman O Charity O the O Medical B-ORG Research I-ORG Council I-ORG MR/L023091/1 O Breast O Cancer O Now O 147 O KCL-BCN-Q3 O the O Cancer O Research O UK O King’s O Health O Partners O Centre O at O King’s O College O London O C604/A25135 O The O research O was O supported O by O the O National O Institute O for O Health O Research O NIHR O Biomedical O Research O Centre O BRC O based O at O Guy’s O and O St O Thomas’ O NHS O Foundation O Trust O and O King’s O College O London O IS-BRC-1215-20006 O The O authors O are O solely O responsible O for O study O design O data O collection O analysis O decision O to O publish O and O preparation O of O the O manuscript O The O views O expressed O are O those O of O the O author(s O and O not O necessarily O those O of O the O NHS O the O NIHR O or O the O Department O of O Health O Grants O for O this O study O were O provided O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O Grant O No. O 31070347 B-AWARD the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG Grant O No. O 2011BAG07B05-3 B-AWARD the O Knowledge B-ORG Innovation I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Grant O No. O KSCX2-EW-Z-4 B-AWARD and O the O Special B-ORG Fund I-ORG for I-ORG Agro-scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Agriculture I-ORG of I-ORG China I-ORG Grant O No. O 201203086 B-AWARD to O Ding O Wang O the O State B-ORG Oceanic I-ORG Administration I-ORG of I-ORG China I-ORG Grant O No. O 201105011-3 B-AWARD and O NSFC O Grant O No. O 31170501 B-AWARD to O Ke-Xiong O Wang O and O the O China B-ORG Scholarship I-ORG Council I-ORG Grant O No. O 2014]3026 B-AWARD to O Zhi-Tao O Wang O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O study O was O supported O by O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG Shanghai I-ORG Municipalit I-ORG Project I-ORG Grant O Number O No.18511102902 B-AWARD Shanghai B-ORG Hospital I-ORG Development I-ORG Center I-ORG Project I-ORG Grant O Number O SHDC22015033 B-AWARD Shanghai B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Project I-ORG Grant O Number O 20184Y0219 B-AWARD and O Interdisciplinary B-ORG Program I-ORG of I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG Grant O Number O YG2017QN661 B-AWARD This O work O was O financially O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Plan I-ORG Grant O No. O 2017YFD0201000 B-AWARD the O National B-ORG Science I-ORG Foundation I-ORG for I-ORG Young I-ORG Scientists I-ORG of I-ORG China I-ORG Grant O No. O 31601631 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No. O 17lgpy109 B-AWARD the O National B-ORG Program I-ORG on I-ORG Key I-ORG Basic I-ORG Research I-ORG Project I-ORG 973 O Program O Grant O No. O 2013CB127602 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O Discipline O construction O fund O project O of O Gansu B-ORG Agricultural I-ORG University I-ORG GAU-XKJS-2018-225 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31260311 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Gansu I-ORG Province I-ORG 1606RJZA034 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2012M512042 O and I-AWARD 2014T70942 O and O the O Ministry B-ORG of I-ORG Agriculture I-ORG CARS-09-P14 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O LH’s O participation O in O this O project O was O supported O by O a O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG Canadian O Graduate O Scholarship O Master’s O Level O CIHR O PIN O 96509 B-AWARD CM’s O participation O in O this O project O was O partially O supported O by O the O Canada B-ORG Research I-ORG Chairs I-ORG Program O grant O number O CRC-2019-00069 B-AWARD and O the O Canada B-ORG Foundation I-ORG for I-ORG Innovation I-ORG grant O number O 33721 B-AWARD ET’s O participation O was O supported O by O a O Canadian O Institutes O of O Health O Research O Banting O Postdoctoral O Fellowship O application O number O 454119 B-AWARD This O work O was O supported O by O the O Czech B-ORG Science I-ORG Foundation I-ORG 21-17720S O The O authors O acknowledge O the O assistance O provided O by O the O Research O Infrastructure O NanoEnviCz O supported O by O the O Ministry B-ORG of I-ORG Education I-ORG Youth I-ORG and I-ORG Sports I-ORG of I-ORG the I-ORG Czech I-ORG Republic I-ORG under O Project O No. O LM2018124 B-AWARD and O the O Research O Infrastructure O EATRIS-CZ O supported O by O the O Ministry O of O Education O Youth O and O Sports O of O the O Czech O Republic O under O Project O No. O LM2018133 B-AWARD This O work O was O supported O by O the O Ministry O of O Education O Youth O and O Sports O of O the O Czech O Republic O and O The B-ORG European I-ORG Union—European I-ORG Structural I-ORG and I-ORG Investments I-ORG Funds I-ORG in I-ORG the I-ORG frame I-ORG of I-ORG Operational I-ORG Programme I-ORG Research I-ORG Development I-ORG and I-ORG Education—project I-ORG Pro-NanoEnviCz I-ORG Project O No. B-AWARD CZ.02.1.01/0.0/0.0/16_013/0001821 O This O work O is O funded O by O the O United B-ORG States I-ORG Department I-ORG of I-ORG Agriculture I-ORG grant O number O 20196702129943 B-AWARD to O F.Z O NIH B-ORG grant O number O R01HL164062 B-AWARD to O F.Z O and O National B-ORG Science I-ORG Foundation I-ORG award O numbers O DMR-2105150 B-AWARD DMR-2207879 B-AWARD OIA-2219142 B-AWARD to O F.Z O This O research O was O supported O by O the O Guangdong B-ORG Laboratory I-ORG for I-ORG Lingnan I-ORG Modern I-ORG Agriculture I-ORG NZ2021012 O Hainan B-ORG Yazhou I-ORG Bay I-ORG Seed I-ORG Lab I-ORG B21HJ0901 O the O Key-Area B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2020B020220008 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31971966 O 31971965 B-AWARD the O China B-ORG Agricultural I-ORG Research I-ORG System I-ORG CARS-04-PS09 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Projects I-ORG 2018YFE0116900-06 O and O the O Guangdong B-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG and I-ORG Promotion I-ORG Project I-ORG 2019KJ136-03 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31771883 O and O 31700580 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hainan I-ORG province I-ORG 319MS093 O the O Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG for I-ORG Chinese I-ORG Academy I-ORG of I-ORG Tropical I-ORG Agricultural I-ORG Sciences I-ORG 1630052017011 O and O 1630022019017 B-AWARD and O the O Research B-ORG Fund I-ORG of I-ORG Guangdong I-ORG University I-ORG of I-ORG Petrochemical I-ORG Technology I-ORG 2018rc55 O The O funders O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21772210 O 41776169 O Guangzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 201804010462 O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2018A0303130219 O the O Scientific O Research O Projects O of O Hubei O education O department O for O Young O Scholars O Q20171109 O Special O Funds O for O Promoting O Economic O Development O Marine O Economic O Development O of O Guangdong O Province O GDME-2018C010 O National O Major O Scientific O and O Technological O Special O Project O for O Significant O New O Drugs O Development O 2018ZX09735001-002-003 O This O work O was O supported O by O the O Special B-ORG Funds I-ORG for I-ORG Discipline I-ORG Construction I-ORG of I-ORG Gansu I-ORG Agricultural I-ORG University I-ORG GAU-XKJS-2018-220 O the O Sheng B-ORG Tongsheng I-ORG Innovation I-ORG Funds I-ORG of I-ORG Gansu I-ORG Agricultural I-ORG University I-ORG under O grant O GSAU-STS-1745 B-AWARD and O GSAU-STS-1638 B-AWARD and O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0201205 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.61602013 O and O No. O 61773229 B-AWARD the O Shenzhen B-ORG Key I-ORG Fundamental I-ORG Research I-ORG Projects I-ORG Grant O No. O JCYJ20170818091546869 B-AWARD and O the O Basic B-ORG Scientific I-ORG Research I-ORG Program I-ORG of I-ORG Shenzhen I-ORG City I-ORG Grant O No. O JCYJ20160331184440545 B-AWARD Min O Yang O was O sponsored O by O CCF-Tencent O Open O Research O Fund O The O funding O body O had O no O role O in O the O design O of O this O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O study O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 52020105013 B-AWARD the O Hubei B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 2022CFB894 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Changsha I-ORG No. O kh2203004 B-AWARD National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2019YFC1604600 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31200941 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 106112016CDJXY290002 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG HeBei I-ORG Province I-ORG 19226631D O U01CA15192001 O R01HG006137 O L.C.X O N.R.Z O and O H.P.J O were O supported O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH O O N.A O was O supported O by O the O National B-ORG Cancer I-ORG Institute's O NCI O Cancer B-ORG Target I-ORG Discovery I-ORG and I-ORG Development I-ORG Consortium I-ORG U01CA17629901 O the O NCI O K99 O CA215256 O and O the O Don O and O Ruth O Seiler O Fund O H.P.J O was O also O supported O by O the O NIH O P01 O CA91955 O H.J.L O and O H.P.J O were O supported O by O the O NIH O O D.M.A O and O C.L O were O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61370131 O Other O support O for O H.P.J O came O from O the O Gastric B-ORG Cancer I-ORG Foundation I-ORG and I-ORG the I-ORG Research I-ORG Scholar I-ORG Grant O RSG-13-297-01-TBG O from O the O American O Cancer O Society O This O research O was O funded O by O Guangxi B-ORG Key I-ORG Laboratory I-ORG of I-ORG Petrochemical I-ORG Resource I-ORG Processing I-ORG and I-ORG Process I-ORG Intensification I-ORG Technology I-ORG 2020K005 O The B-ORG Key I-ORG Laboratory I-ORG of I-ORG Fine I-ORG Chemical I-ORG Application I-ORG Technology I-ORG of I-ORG Luzhou I-ORG HYJH-2102-B O and O The O Opening B-ORG Foundation I-ORG of I-ORG The I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Molecular I-ORG Engineering I-ORG of I-ORG Polymers I-ORG K2020-24 O This O research O was O funded O by O the O UK O Engineering B-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG EPSRC O grant O numbers O EP/M020983/1 B-AWARD and O EP/R028745/1 B-AWARD and O Impact O Acceleration O Award O University O of O York O IAA O grants O G0036701 B-AWARD and I-AWARD G0025101 O AS O is O funded O by O the O European O Union’s O Horizon O 2020 O research O and O innovation O program O under O the O Marie O Skłodowska-Curie O grant O agreement O No. O 766402 O AAAM O acknowledges O PhD O studentship O funding O from O Taif O University O Saudi O Arabia O We O acknowledge O additional O financial O support O from O the O Wellcome B-ORG Trust I-ORG grants O 092506 O and O 098335 O and O the O UK O Medical B-ORG Research I-ORG Council I-ORG MRC O MR/M008991/1 B-AWARD This O work O was O founded O by O Harbin B-ORG Medical I-ORG University I-ORG Innovative I-ORG Scientific I-ORG Research I-ORG Grants I-ORG 2016LCZX41 O to O Wen-Jia O Chen O the O First B-ORG Affiliated I-ORG Hospital I-ORG of I-ORG Harbin I-ORG Medical I-ORG University I-ORG Science I-ORG Fund I-ORG 2014B08 O to O Wen-Jia O Chen O and O Heilongjiang B-ORG Postdoctoral I-ORG Grant(LBH-Z14116 O to O Wen-Jia O Chen O NJW O is O the O recipient O of O the O Wellcome B-ORG Trust I-ORG Award O Number O 101148/Z/13/Z B-AWARD AMD O is O the O recipient O of O the O Bill B-ORG and I-ORG Melinda I-ORG Gates I-ORG Foundation I-ORG Award O Number O OPP1081420 B-AWARD JAS O is O the O recipient O of O the O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG Award O Number O 1104975 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O grants O funded O by O the O Korea O Government O the O Ministry O of O Science O and O ICT O O Future O Planning O 2015M3A9A7067220 O 2014R1A2A1A10052404 I-AWARD and I-AWARD 2013M3A9A7046303 O It O was O also O supported O by O a O grant O of O the O Korean O Health O Technology O R&D O Project O Ministry B-ORG of I-ORG Health I-ORG and I-ORG Welfare I-ORG Republic I-ORG of I-ORG Korea I-ORG HI13C2162 O the O KUSTAR-KAIST B-AWARD Institute O KAIST O Korea O and O the O KAIST B-AWARD Future I-AWARD Systems I-AWARD Healthcare I-AWARD Project I-AWARD from O the O Ministry B-ORG of I-ORG Science I-ORG ICT I-ORG and I-ORG Future I-ORG Planning I-ORG This O work O was O supported O by O the O Deutsche B-ORG Krebshilfe/Dr I-ORG Mildred-Scheel-Stiftung I-ORG 109102 O and O the O European B-ORG Union I-ORG EU-FP-7 O EPC-TM B-AWARD and O EU-FP7-REGPOT-2010–1 B-AWARD PePPP B-ORG Center I-ORG of I-ORG Excellence I-ORG MV O ESF/14-BM-A55-0045/16 O ESF B-AWARD MV I-AWARD V-630-S-150–2012/132/133 O and O CRU B-AWARD Cancer I-AWARD UK I-AWARD and I-AWARD the I-AWARD Liverpool I-AWARD Cancer I-AWARD Trials I-AWARD Unit I-AWARD Liverpool I-AWARD DFG O SFB-1321 O Project O A14 O This O work O was O supported O by O grants O from O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG R.O.C I-ORG NSC96-3112-B-002-033 O NSC97-3112-B-002-009 B-AWARD NSC98-3112-B-002-004 B-AWARD NSC B-AWARD 101-2314-B-002-136-MY3 O MOST102-2314-B-002-019 B-AWARD National B-ORG Taiwan I-ORG University I-ORG AIM O for I-AWARD Top I-AWARD University I-AWARD Excellent I-AWARD Research I-AWARD Project I-AWARD 10R81918-03 O 101R892103 B-AWARD 102R892103 B-AWARD and O National B-ORG Taiwan I-ORG University I-ORG Hospital I-ORG NTUH105-18 O Taiwan O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31900252 O 31972445 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG funded O project O 2018M641761 O the O Department B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Jilin I-ORG Province I-ORG 20190201299JC O 20190303095SF I-AWARD 20130604037TC O the O Programme O for O Introducing O Talents O to O Universities O B07017 O and O the O Fundamental O Research O Fund O for O the O Central O Universities O The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 11902059 O Postdoctoral O Program O for O Innovative O Talents O of O Chongqing O CQBX201805 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2019M663434 O and O Chongqing B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Project O cstc2019jcyj-bshX0054 O This O research O was O funded O by O the B-ORG Andalusian I-ORG regional I-ORG government I-ORG FEDER-UCA18-107490 O the B-ORG European I-ORG Union’s I-ORG Horizon I-ORG 2020 I-ORG research I-ORG and I-ORG innovation I-ORG program I-ORG grant O agreement O 823717–ESTEEM3 B-AWARD the B-ORG Spanish I-ORG Ministerio I-ORG de I-ORG Economía I-ORG y I-ORG Competitividad I-ORG PID2019-107578GA-I00 O the B-ORG Ministerio I-ORG de I-ORG Ciencia I-ORG e I-ORG Innovación I-ORG MCIN/AEI/10.13039/501100011033 B-AWARD and O the B-ORG European I-ORG Union I-ORG “NextGenerationEU”/PRTR I-ORG RYC2021-033764-I O CPP2021-008986 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 41590845 B-AWARD 41421001 B-AWARD and O 41601462 B-AWARD the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG grant O number O 2015CB954101 B-AWARD the O Key O Research O Program O of O Frontier O Science O Chinese O Academy O of O Sciences O grant O number O QYZDY-SSW-DQC007-1 B-AWARD the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Key I-ORG Project I-ORG grant O number O 2016YFB0502301 B-AWARD and O the O Youth O Science O Funds O of O the O State O Key O Laboratory O of O Resources O and O Environmental O Information O System O Chinese O Academy O of O Sciences O grant O number O O8R8A083YA B-AWARD This O research O was O funded O by O the O LEAD B-ORG Graduate I-ORG School I-ORG I-ORG Research I-ORG Network I-ORG GSC1028 O which O is O funded O within O the O framework O of O the O Excellence O Initiative O of O the O German O federal O and O state O governments O supporting O CA O and O TD. O This O research O was O further O funded O by O a O grant O from O the O Science B-ORG Campus I-ORG Tuebingen O project B-AWARD 8.4 I-AWARD to O HCN O supporting O MS. O ACE O was O partly O supported O by O the O IZKF B-ORG Tübingen I-ORG Junior O Research O Group O Grant O 2115-0-0 B-AWARD This O research O was O funded O by O Ministero O dell’Istruzione O dell’Università O e O della O Ricerca O MIUR O PRIN O 2015KEZNYM O NEMO O Ministero B-ORG degli I-ORG Affari I-ORG Esteri I-ORG e I-ORG della I-ORG Cooperazione I-ORG Internazionale O project O NOICE B-AWARD Joint I-AWARD Laboratory O European O Union’s O Horizon O 2020 O research O and O innovation O programme O Qombs O Project O FET O Flagship O on O Quantum O Technologies O grant O no. O 820419 O the O Rutherford B-AWARD Discovery I-AWARD Fellowships I-AWARD of O the O Royal B-ORG Society I-ORG of I-ORG New I-ORG Zealand I-ORG and O the O Marsden O Fund O of O the O Royal O Society O of O New O Zealand O The O work O of O S. O W. O is O supported O by O the O Ministry B-ORG of I-ORG Education I-ORG and I-ORG Science I-ORG of I-ORG the I-ORG Russian I-ORG Federation I-ORG Minobrnauka O 14.Y26.31.0017 O T.H O acknowledges O funding O from O the O Swedish O Research O Council O Grant O No. O 2017-05309 O This O work O is O supported O by O grants O from O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Pillar I-ORG Program I-ORG of I-ORG China I-ORG 2012BAI05B03 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31670959 O and I-AWARD 81171422 O and O the O Key B-ORG Projects I-ORG in I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Beijing I-ORG Municipal I-ORG Education I-ORG Commission I-ORG China I-ORG KZ201210025022 O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH O R01 O GM114340 O March B-ORG of I-ORG Dimes I-ORG FY15-BOC-2141 O Searle O Scholars O Program O to O D.J.S O J.S.O O was O supported O by O an O American B-ORG Cancer I-ORG Society–New O York O Cancer O Research O Fund O postdoctoral O fellowship O PF-16-096-01-DMB O Funding O for O open O access O charge O NIH O GM114340 O The O following O agencies O supported O this O work O the O National B-ORG Council I-ORG of I-ORG Technological I-ORG and I-ORG Scientific I-ORG Development I-ORG CNPq O Process I-AWARD 481226/2013-3 O Foundation B-ORG of I-ORG Protection I-ORG to I-ORG Research I-ORG of I-ORG the I-ORG State I-ORG of I-ORG Minas I-ORG Gerais–FAPEMIG I-ORG process O APQ-02387-14 O Fundect-MS B-ORG 007/2015 O SIAFEM I-AWARD 025139 O and O Coordination B-ORG for I-ORG the I-ORG Improvement I-ORG of I-ORG Higher I-ORG Education I-ORG Personnel I-ORG CAPES O the O BIGA B-AWARD Project I-AWARD CFP I-AWARD 51/2013 I-AWARD process I-AWARD 3385/2013 O Leandro O Marcio O Moreira O João O Carlos O Setubal O Nalvo O Franco O de O Almeida O and O Jesus O Aparecido O Ferro O have O a O research O fellowship O from O CNPq O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 71101155 B-AWARD to O JQ O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG Grant O No. O 2015JJ2184 B-AWARD to O JQ O and O Independent B-ORG Exploration I-ORG and I-ORG Innovation I-ORG Project I-ORG of I-ORG Central I-ORG South I-ORG University I-ORG Grant O No. O 2015zzts208 B-AWARD to O YH O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O has O received O funding O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81472171 B-AWARD and O grant O number O 81672299 B-AWARD the O State B-ORG Scholarship I-ORG Fund I-ORG of I-ORG China(File O Number O 201308330145 B-AWARD and O Project B-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG Zhejiang I-ORG Province I-ORG China I-ORG File O Number O 2017KY058 B-AWARD The O funding O sources O had O no O role O in O the O study O design O data O collection O data O analysis O or O interpretation O of O the O findings O This O project O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81671500 O Jiangsu B-ORG Provincial I-ORG Six I-ORG Talent I-ORG Peaks I-ORG WSN-157 O 333 B-ORG project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Nanjing I-ORG Sanitation I-ORG Engineering I-ORG of I-ORG Young I-ORG Talents I-ORG during I-ORG the I-ORG 13th I-ORG Five-Year I-ORG Plan I-ORG Period I-ORG QRX17076 O and O Jiangsu B-ORG Provincial I-ORG Special I-ORG Program I-ORG of I-ORG Medical I-ORG Science I-ORG BL2012018 O The O study O is O funded O by O seven O research O projects O The O details O are O as O follows O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number:31900848 O the O Project O Foundation O of O Sichuan B-ORG Provincial I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG grant O number:2022NSFSC1724 O the B-ORG Sichuan I-ORG Key I-ORG Laboratory I-ORG of I-ORG Sports I-ORG Medicine I-ORG and I-ORG or I-ORG the I-ORG Key I-ORG Laboratory I-ORG of I-ORG Sports I-ORG Medicine I-ORG of I-ORG the I-ORG State I-ORG Administration I-ORG of I-ORG Sports I-ORG grant O number:2022-A045 O the B-ORG Innovative I-ORG Project I-ORG of I-ORG Chengdu I-ORG Institute I-ORG of I-ORG Physical I-ORG Education I-ORG and I-ORG Health I-ORG Institute/Zheng I-ORG Huaixian I-ORG Bone I-ORG and I-ORG Trauma I-ORG Research I-ORG Institute I-ORG from O 2021 O to O 2022 O grant O nos:CX21B05 O CX21C09 B-AWARD CX21A02 B-AWARD the B-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG Anhui I-ORG Province I-ORG Department I-ORG of I-ORG Education I-ORG grant O number:2022AH051691 O This O research O was O partially O funded O by O BovMais B-ORG Project–PDR2020-101-031130 O This O publication O was O funded O by O the O Centre B-ORG for I-ORG Interdisciplinary I-ORG Research I-ORG in I-ORG Animal I-ORG Health I-ORG CIISA O grant O UIDB/00276/2020 B-AWARD and O by O the O Associate B-ORG Laboratory I-ORG for I-ORG Animal I-ORG and I-ORG Veterinary I-ORG Sciences I-ORG AL4AnimalS O grant O LA/P/0059/2020 B-AWARD A.V O was O supported O by O a O FCT—Fundação B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG Tecnologia I-ORG IP I-ORG PhD I-ORG fellowship I-ORG grant O number O 2020.09881.BD B-AWARD This O work O was O supported O by O Victoria B-ORG University I-ORG Wellington I-ORG grant O 80837 B-AWARD to O Ken O G. O Ryan O and O NIWA’s O research O projects O “Impact O of O resource O use O on O vulnerable O deep-sea O communities” O funded O by O the O New B-ORG Zealand I-ORG Ministry I-ORG for I-ORG Business I-ORG Innovation I-ORG and I-ORG Employment I-ORG CO1X0906 O and O “Coasts O and I-ORG Oceans I-ORG Research I-ORG Programme I-ORG 2 I-ORG Marine I-ORG Biological I-ORG Resources I-ORG Discovery I-ORG and I-ORG definition I-ORG of I-ORG the I-ORG marine I-ORG biota I-ORG of I-ORG New I-ORG Zealand I-ORG 2015/2016 O SCI)” O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O publication O is O based O upon O work O supported O by O the O projects O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31671286 O 31672397 I-AWARD and I-AWARD 31771374 O Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG of I-ORG China I-ORG JQ201709 O the B-ORG Major I-ORG Project I-ORG of I-ORG National I-ORG Transgene I-ORG in I-ORG China I-ORG 2018ZX08007001–002 O the B-ORG Program I-ORG of I-ORG National I-ORG Cow I-ORG Industrial I-ORG Technology I-ORG System I-ORG of I-ORG China I-ORG CARS-37 O and O the B-ORG Shandong I-ORG Provincial I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017GNC10120 O The O funding O bodies O had O no O role O in O the O study O design O collection O analysis O and O interpretation O of O data O and O in O the O writing O of O the O manuscript O This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81873246 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG Municipality O grant O number O 18ZR1439900 B-AWARD and O Scientific B-ORG and I-ORG Technological I-ORG Innovation I-ORG Projects I-ORG of I-ORG Longhua I-ORG Hospital I-ORG grant O number O CX201766 B-AWARD This O study O was O supported O by O the O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2013CB127701 O the O Special B-ORG Fund I-ORG for I-ORG Agro-scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG 201303016 O and O the O National B-ORG Natural I-ORG Science I-ORG Found I-ORG of I-ORG China I-ORG 31171829 O This O work O was O supported O by O the O Ministry B-ORG of I-ORG Education I-ORG Humanities I-ORG Social I-ORG Sciences I-ORG 18YJA190008 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31500870 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20181029 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2017B14514 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017M621603 O China B-ORG Scholarship I-ORG Council I-ORG Foundation I-ORG 201706715037 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG College I-ORG of I-ORG China I-ORG 17KJB190002 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Youth B-ORG Innovation I-ORG Promotion I-ORG Association I-ORG CAS I-ORG No. O 2012274 O the O CAS O “Light O of O West O China” O Program O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31772464 O and O the O Youth B-ORG Professor I-ORG Project I-ORG of I-ORG the I-ORG CIB I-ORG No. O Y3B3011 O to O Jianguo O Cui O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81272880 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG 17ZR1404100 O Shanghai B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG 201640287 O and O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG 124119b1300 O to O GX O and O a O grant O from O Committee B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Jinshan I-ORG District I-ORG JSKJ-KTMS-2015-01 O to O XT. O Xiaoling O Tian O is O recipient O of O a O postdoctoral O fellowship O from O Fudan O University O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51507144 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O XDJK2019B021 O the O Chongqing B-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG CSTC O No. O cstc2016jcyjA0400 O the O project O of O China O Scholarship O Council O CSC O and O Fundamental O Research O Funds O for O the O Central O Universities O No. O 2019CDJGFCL001 O and O XDJK2019B021 O This O research O was O funded O by O JSPS B-ORG KAKENHI I-ORG Grant O Number O 20K09404 B-AWARD M.N O received O grants O from O the O Japan B-ORG Agency I-ORG for I-ORG Medical I-ORG Research I-ORG and I-ORG Development I-ORG AMED O Grant O Numbers O JP16km0405205 B-AWARD JP19km0405501 I-AWARD JP20ek0109492 I-AWARD JP21wm0425009 I-AWARD JP20ek0109485 I-AWARD JP18ek0109348 I-AWARD JP21ek0109548 I-AWARD and I-AWARD JP22fk0210111 O K.T O received O grants O from O AMED O JP16 O km0405205 I-AWARD and I-AWARD JP19 I-AWARD km0405501 O Y.K O received O a O grant O from O AMED O JP19 O km0405501 O This O work O was O partially O supported O by O “Joint B-ORG Usage/Research I-ORG Center I-ORG for I-ORG Interdisciplinary I-ORG Large I-ORG scale I-ORG Information I-ORG Infrastructures” I-ORG and I-ORG “High-Performance I-ORG Computing I-ORG Infrastructure” I-ORG in O Japan O Project O ID: O jh200038 B-AWARD MDH I-AWARD jh210009 I-AWARD MDH I-AWARD and I-AWARD jh220048 O M.N O was O partially O funded O by O JSPS O KAKENHI O Grant O Number O 21H02681 B-AWARD This O publication O is O supported O by O COST B-ORG Action O FA1304 B-AWARD ‘Swimming O of O fish O and O implications O for O migration O and O aquaculture O FITFISH)’ O through O the O funding O of O a O Short B-ORG Term I-ORG Scientific I-ORG Mission I-ORG COST-STSM-FA1304-25027 O of O C.M O Alexandre O The O first O author O is O also O supported O by O the O Portuguese B-ORG Science I-ORG Foundation O through O a O post-doctoral O grant O SFRH/BPD/108582/2015 O and O through O its O pluriannual O funding O programme O to O MARE B-ORG UID/MAR/04292/2013 O This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O no. O 2018YFB0504500 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 41801268 B-AWARD and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG China I-ORG University I-ORG of I-ORG Geosciences I-ORG Wuhan O grant O no. O CUG170661 B-AWARD This O study O was O funded O by O a O Medical B-ORG Research I-ORG Council I-ORG and O St. O George’s O Hospital O Medical O School O PhD O studentship O awarded O to O EP O Grant O No. O G0700019/G0800110 B-AWARD the O Association B-ORG for I-ORG International I-ORG Cancer I-ORG Research I-ORG Grant O No. O 09-0310 B-AWARD and O the O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG Grant O No. O S20430 B-AWARD The O study O was O financially O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81372998 O the B-ORG Open I-ORG Project I-ORG of I-ORG Hubei I-ORG Key I-ORG Laboratory I-ORG of I-ORG Wudang I-ORG Local I-ORG Chinese I-ORG Medicine I-ORG Research I-ORG Hubei O University O of O Medicine O WDCM2018002 O the B-ORG Key I-ORG Discipline I-ORG Project I-ORG of I-ORG Hubei I-ORG University I-ORG of I-ORG Medicine I-ORG and I-ORG the I-ORG Foundation I-ORG for I-ORG Innovative I-ORG Research I-ORG Team I-ORG of I-ORG Hubei I-ORG University I-ORG of I-ORG Medicine I-ORG FDFR201602 O 2018YHKT01 B-AWARD the B-ORG Key I-ORG Discipline I-ORG Project I-ORG of I-ORG Hubei I-ORG Province I-ORG 2014XKJSXJ18 O The O funders O played O no O role O in O the O design O of O this O study O and O collection O analysis O and O interpretation O of O data O and O writing O the O manuscript O which O are O fully O the O responsibilities O of O the O authors O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O nos O 81770255 B-AWARD Natural B-ORG Science I-ORG Fund I-ORG Project I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG of I-ORG China I-ORG Grant O nos O H201314 B-AWARD Harbin B-ORG medical I-ORG university I-ORG innovation I-ORG fund I-ORG foundation I-ORG research I-ORG project I-ORG Grant O number O YJSCX2017-40HYD B-AWARD This O study O was O supported O by O The B-ORG National I-ORG Key I-ORG Research I-ORG Development I-ORG Program I-ORG of I-ORG China(2016YFD0101102 O Guangdong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2017A030313151 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31471426 O Guangdong B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 2015B020231002 O and O 2017B030314173 B-AWARD and O The B-ORG Team I-ORG Project I-ORG of I-ORG Guangdong I-ORG Agricultural I-ORG Department I-ORG 2017LM2148 O This O research O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 32102533 B-AWARD National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFE0128000 O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG of I-ORG MOF I-ORG and I-ORG MARA I-ORG CARS-41 O and O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG ASTIP-IAS04 O and O CAASZDRW202005 B-AWARD This O work O was O supported O by O the B-ORG National I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2015CB755906 O Hao O Chen O NSFC-Shandong B-ORG Joint I-ORG Fund I-ORG for I-ORG Marine I-ORG Science I-ORG Research I-ORG Centers I-ORG U1606401 O Xuefa O Shi O National O Natural O Science O Foundation O of O China,http://www.nsfc.gov.cn O and O The B-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG Project I-ORG of I-ORG Qingdao I-ORG National I-ORG Laboratory I-ORG for I-ORG Marine I-ORG Science I-ORG and I-ORG Technology I-ORG Grant O number O No.2016ASKJ14 B-AWARD awarded O to O Hao O Chen O This O research O was O supported O financially O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31560725 B-AWARD No.31702379 O No. O 41666006 B-AWARD the O National B-ORG Marine I-ORG Public I-ORG Welfare I-ORG Research I-ORG Project I-ORG of I-ORG China I-ORG No. O 201405020-4 B-AWARD the O Key B-ORG Research I-ORG Project I-ORG of I-ORG Hainan I-ORG Province I-ORG ZDKJ2016011 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hainan I-ORG Province I-ORG No. O 2016CXTD005 B-AWARD No. O 20163054 B-AWARD and O the O Hainan B-ORG University I-ORG Campus I-ORG Team I-ORG Project I-ORG 2017 I-ORG hdkytg201704 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O is O funded O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2015A03030817 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61976239 O and O Innovation B-ORG Foundation I-ORG of I-ORG High-end I-ORG Scientific I-ORG Research I-ORG Institutions I-ORG of I-ORG Zhongshan I-ORG City I-ORG of I-ORG China I-ORG 2019AG031 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51703096 B-AWARD Industry O Foresight O and O Generic O Key O Technology O of O Suqian O H201816 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M64229 O and O the O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O This O study O was O partly O supported O by O the O European B-ORG Community’s I-ORG 7th I-ORG Framework I-ORG Program I-ORG FP7/2007-2013 O under O grant O agreement O no. O 278486 B-AWARD acronym O “DEVELAGE” B-ORG EZ, O JMV O and O a O DAAD B-ORG PROCOPE I-ORG Grant O No. O 55924926 B-AWARD MJ O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 12002003 B-AWARD and O No. O 11972140 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG No. O E2021409021 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Research I-ORG Foundation I-ORG for I-ORG Universities I-ORG of I-ORG Hebei I-ORG Province I-ORG No. O ZD2020131 B-AWARD and O No. O QN2023042 B-AWARD the O Langfang B-ORG Youth I-ORG Talent I-ORG Support I-ORG Program I-ORG No. O LFBJ202001 B-AWARD and O No. O LFBJ202204 B-AWARD and O Project B-ORG 333 I-ORG of I-ORG Hebei I-ORG Province I-ORG No. O C20221033 B-AWARD This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O numbers O 61701143 B-AWARD 81372213 B-AWARD and O 81572935 B-AWARD the B-ORG Joint I-ORG Scientific I-ORG and I-ORG Technology I-ORG Innovation I-ORG Fund I-ORG of I-ORG Fujian I-ORG Province I-ORG Grant O number O 2016Y9044 B-AWARD and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Provincial I-ORG Universities I-ORG 2017JCZX48 O This O research O was O funded O by O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG R15-GM132803 O to O ETP O and O YK; O National B-ORG Science I-ORG Foundation I-ORG MRI I-ORG grants O at O the O University O of O Alabama O CHE O 1726812 B-AWARD 1828078 B-AWARD 1919906 B-AWARD for O MS, O SC O XRD O and O NMR O instruments O and O the O National B-ORG Cancer I-ORG Institute I-ORG R01CA222227 O to O SAM O for O support O in O part O of O this O work O Funding O The O study O was O funded O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.31372464 O to O EMZ O and O No. O 31402233 B-AWARD and O No. O 31672583 B-AWARD to O QZ, O Technology B-ORG Research I-ORG and I-ORG innovation I-ORG of I-ORG Shaanxi I-ORG province I-ORG 2015NY170 O to O YNS O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2452015035 O to O YNS O 2014YB013 O to O TFD O and O 2452016048 O to O QZ. O This O research O is O partially O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31571650 O and I-AWARD 31771785 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0100701 O Key O Projects O in O Shaanxi O Provincial O Agricultural O Field O 2018ZDXM-NY-006 O and O Basic B-ORG Research I-ORG Projects I-ORG of I-ORG the I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 2015JM3095 O The O funders O Jixin O Zhao O and O Xinhong O Chen O conceived O and O designed O this O research O The O funding O bodies O didn’t O play O a O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O study O was O supported O by O two O grants B-ORG from I-ORG the I-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG Nos O 2016YFC1305405 B-AWARD and O 2011BAI10B01 B-AWARD two O grants B-ORG from I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Fund I-ORG Nos O 81425008 B-AWARD and O 81621092 B-AWARD and O a B-ORG grant I-ORG by I-ORG Peking I-ORG University I-ORG Health I-ORG Science I-ORG Center I-ORG No. O BMU2017CJ002 B-AWARD a O grant O from O the O University O of O Michigan O Health O System O and O Peking O University O Health O Sciences O Center O Joint O Institute O for O Translational O and O Clinical O Research O This O study O was O supported O by O the O Project O funded O by O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017M611257 O Teachers B-ORG guide I-ORG undergraduates I-ORG scientific I-ORG research I-ORG training I-ORG project I-ORG of I-ORG Liaoning I-ORG Normal I-ORG University I-ORG CX201902062 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31501911 O General O Scientific O Research O Foundation O of O Liaoning O Educational O Committee O L2015293 O and O Youth O Scientific O Research O Project O of O Liaoning O Normal O University O LS2014L008 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 72211540398 B-AWARD the O Beijing B-ORG Natural I-ORG Science I-ORG Foundation-Haidian I-ORG Original I-ORG Innovation I-ORG Joint I-ORG Foundation I-ORG grant O number O L222027 B-AWARD and O the O Beijing B-ORG High-Level I-ORG Public I-ORG Health I-ORG Technical I-ORG Personnel I-ORG Training I-ORG Program I-ORG grant O number O 2022-1-005 B-AWARD 2023-2-44 O This O project O was O supported O by O National B-ORG Special I-ORG Fund I-ORG for I-ORG Forestry I-ORG Scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG Grant O No. I-AWARD 201504406 O the B-ORG Priority I-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O Jiangsu B-ORG Agriculture I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Fund I-ORG Grant O No. I-AWARD CX I-AWARD 17)1004 O the B-ORG National I-ORG traditional I-ORG Chinese I-ORG medicine I-ORG standardization I-ORG project I-ORG ZYYS-2014 O 12 O This O work O was O financially O supported O by O UCSI B-ORG University I-ORG CERVIE I-ORG Conference I-ORG Funding I-ORG CONF-NATN-FAS-126 O UCSI B-ORG University I-ORG Postgraduate I-ORG Student I-ORG Conferences I-ORG Funding I-ORG CONF-NAT-FAS-10 O The O Ministry B-ORG of I-ORG Higher I-ORG Education I-ORG Malaysia I-ORG MOHE I-ORG through I-ORG the I-ORG Fundamental I-ORG Research I-ORG Grant I-ORG Scheme I-ORG FRGS/1/2017/STG05/UCSI/03/2 O and O UCSI B-ORG University I-ORG PSIF I-ORG Grants O Proj-In-FAS-041 O O Proj-In-FAS-061 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O present O study O was O supported O by O The B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0501003 O The B-ORG Outstanding I-ORG Talents I-ORG Training I-ORG Program I-ORG of I-ORG Guangdong I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-35 O Supporting O Program O for O Guangdong O Agricultural O Research O O Development O Center O of O Livestock O and O Poultry O Healthy O Breeding O Operating B-ORG Funds I-ORG for I-ORG Guangdong I-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Animal I-ORG Breeding I-ORG and I-ORG Nutrition I-ORG 2014B030301054 O The O project O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81672139 B-AWARD O 81601885 B-AWARD Doctoral B-ORG Start-up I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province I-ORG 20170520015 O and O Dalian B-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG Project I-ORG 2017RQ153 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81300398 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O China O 2015A030313528 O and O 2013 B-ORG Sail I-ORG Plan I-ORG “the I-ORG Introduction I-ORG of I-ORG the I-ORG Shortage I-ORG of I-ORG Top-Notch I-ORG Talent” I-ORG Project I-ORG YueRenCaiBan O 2014 I-AWARD 1). O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31901872 O the O Ph. B-ORG D. I-ORG Programs I-ORG Foundation I-ORG of I-ORG Henan I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 13480048 O and O the O Key B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Henan I-ORG Province I-ORG 182102110255 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O ‘the O Federation B-ORG of I-ORG European I-ORG Microbiological I-ORG Societies’ O FEMS O RG B-AWARD 2015 I-AWARD 0085 I-AWARD to O FG O ‘the O German B-ORG Academic I-ORG Exchange I-ORG Service’ O Short-Term O Research O Grant O 91608317 B-AWARD to O FG O ‘the O Islamic B-ORG Development I-ORG Bank’ O PhD O Merit O Scholarship O 33-R B-AWARD IRN I-AWARD P34 I-AWARD to O FG O and O ‘the O Deutsche B-ORG Forschungsgemeinschaft’ O CRC O 1127 I-AWARD ChemBioSys O to O TW O The O authors O would O like O to O acknowledge O networking O support O by O the O COST O Action O ‘Phycomorph’ O FA1406 O through O Short O Term O Scientific O Missions O This O research O was O funded O by O the O ‘JBGS’ B-ORG Project I-ORG of I-ORG Seed I-ORG Industry I-ORG Revitalization I-ORG in I-ORG Jiangsu I-ORG Province I-ORG JBGS(2021)095 O Special B-ORG Fund I-ORG for I-ORG Jiangsu I-ORG Provincial I-ORG Forestry I-ORG Innovation I-ORG and I-ORG Promotion I-ORG LYKJ(2021)06 O Special B-ORG Fund I-ORG for I-ORG Forestry I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Province I-ORG sczh O 2022 I-AWARD No. I-AWARD 18 O Jiangsu B-ORG Agricultural I-ORG industrial I-ORG Technology I-ORG system I-ORG construction I-ORG project I-ORG JATS(2022)101 O Jiangsu B-ORG Provincial I-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG CX O 22)3061 O the O Central B-ORG Financial I-ORG Services I-ORG Demonstration I-ORG Funds I-ORG for I-ORG Forestry I-ORG Science I-ORG and I-ORG Technology I-ORG Promotion I-ORG Project I-ORG Su O 2021 I-AWARD TG06 O This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG under O Grant O 2022YFF0706003 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Tianjin I-ORG under O Grant O 22JCYBJC00090 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O 62175179 B-AWARD This O research O was O funded O by O the O Chongqing B-ORG Social I-ORG Science I-ORG Planning I-ORG Fund I-ORG grant O number O 2021NDYB050 B-AWARD Chongqing B-ORG University I-ORG Central I-ORG University I-ORG Scientific I-ORG Research I-ORG Basic I-ORG Business I-ORG Fee I-ORG Project I-ORG grant O number O 2022CDSKXYJG007 B-AWARD and O State B-ORG Scholarship I-ORG Fund I-ORG of I-ORG China I-ORG Scholarship I-ORG Council I-ORG grant O number O CSCNO.202106050050 B-AWARD This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 52175079 B-AWARD and O 11972204 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG China I-ORG Grant O No. B-AWARD N2103026 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2020M680990 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grants O 31900841 B-AWARD 32071166 B-AWARD and O 32072254 B-AWARD CAS B-ORG Key I-ORG Laboratory I-ORG of I-ORG Nutrition I-ORG Metabolism I-ORG and I-ORG Food I-ORG Safety I-ORG KLNMFS2019-01 O Six B-ORG Talent I-ORG Peaks I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG NY-119 O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2020YFC1606804 O the O Research B-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Wuxi I-ORG N20203005 O This O work O was O supported O by O grants O from O Shandong B-ORG Provincial I-ORG key I-ORG research I-ORG and I-ORG development I-ORG program I-ORG China I-ORG 2017GSF21107 O Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG China I-ORG ZR2016CM05 O and O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFE0200300 O These O funding O bodies O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U22A20319 O 82071691 B-AWARD 81872395 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Ningxia I-ORG Province I-ORG 2022AAC02027 O and O Scientific B-ORG research I-ORG project I-ORG of I-ORG Ningxia I-ORG Medical I-ORG University I-ORG XZ2020006 O This O work O was O supported O by O the O Spanish O SAF2008-05674-C03-01 O European B-ORG Twins I-ORG Study I-ORG Network I-ORG on I-ORG Schizophrenia I-ORG Research I-ORG Training I-ORG Network I-ORG grant O number O EUTwinsS B-AWARD MRTN-CT-2006-035987 B-AWARD the O Catalan B-ORG 2017SGR1577 B-AWARD and O the O Ministry O of O Science O and O Innovation O PIM2010ERN-00642 O in O frame O of O ERA-NET O NEURON O Thanks O to O the O Spanish O Ministry O of O Economy O and O Competitivity O ES-EUEpiBrain O project O grant O SAF2015-71526-REDT O This O work O was O supported O by O the O Spanish B-ORG Ministry I-ORG of I-ORG Economy I-ORG and I-ORG Competitivity I-ORG Instituto I-ORG de I-ORG Salud I-ORG Carlos I-ORG III I-ORG PI15/00097 O – O Ayuda O cofinanciada O por O el O Fondo O Europeo O de O Desarrollo O Regional O FEDER O “Una O manera O de O hacer O Europa” O Helena O Palma-Gudiel O was O supported O by O the O Secretaria B-ORG d'Universitats I-ORG i I-ORG Recerca I-ORG del I-ORG Departament I-ORG d'Economia I-ORG i I-ORG Coneixement I-ORG de I-ORG la I-ORG Generalitat I-ORG de I-ORG Catalunya I-ORG 2017FI_B2_00057 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Korea B-ORG Industrial I-ORG Technology I-ORG Association I-ORG KOITA O funded O by O the O Ministry O of O Science O and O ICT O MSIT O in O the O Korean O government O grant O number O KOITA-RND2-2022-1 B-AWARD the O Korea O Health O Technology O R&D O project O through O the O Korea B-ORG Health I-ORG Industry I-ORG Development I-ORG Institute I-ORG KHIDI O funded O by O the O Ministry O of O Health O O Welfare O Republic O of O Korea O grant O number O HR22C1734 B-AWARD the O Technology O Development O Program O of O the O Ministry B-ORG of I-ORG SMEs I-ORG and I-ORG Startups I-ORG grant O number O S3263796 B-AWARD and O the O Basic O Science O Research O Program O through O the O National B-ORG Research I-ORG Foundation I-ORG NRF O funded O by O the O Korean O Ministry O of O Education O grant O number O NRF-2021R1F1A1062311 B-AWARD This O research O was O funded O by O the O Major B-ORG Project I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 41590841 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG No. O 2016YFC0503001 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Tianjin I-ORG China I-ORG No. O 18JCYBJC90900 B-AWARD the O Project B-ORG of I-ORG Scientific I-ORG Research I-ORG Plan I-ORG of I-ORG Tianjin I-ORG Education I-ORG Commission I-ORG No. O 2018KJ164 B-AWARD and O Tianjin B-ORG Education I-ORG Commission I-ORG Research I-ORG Project I-ORG No. O 2016CJ20 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O We O gratefully O acknowledge O the O following O funding O Office O of O Research O Development O Phramongkutklao O College O of O Medicine O O Phramongkutklao O Hospital O ORD O PCM O O PMK O Bangkok O Thailand O Thailand B-ORG Research I-ORG Fund I-ORG TRG6080009 O British O Council O and O Newton B-ORG Fund I-ORG Thailand-UK O Researcher O Link O Award O 2017-18 O PDG61W0015 O Nicholas O Casewell O was O supported O by O a O Sir O Henry O Dale O Fellowship O 200517/Z/16/Z O jointly O funded O by O the O Wellcome B-ORG Trust I-ORG and O Royal O Society O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O following O grants O Zhejiang B-ORG University I-ORG Ningbo I-ORG Institute I-ORG of I-ORG Technology O 20190418Z0047 B-AWARD Dr. O Xinkai O Wang O Zhejiang B-ORG University I-ORG Ningbo I-ORG Institute I-ORG of I-ORG Techonology O 20900545850 B-AWARD Dr. O Xinkai O Wang O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province O LQ19E080010 B-AWARD Qianqian O Zhang O MOE B-ORG Ministry I-ORG of I-ORG Education I-ORG in I-ORG China I-ORG Project I-ORG of I-ORG Humanities I-ORG and I-ORG Social I-ORG Sciences O 19YJC760122 B-AWARD Dr. O Xinkai O Wang O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O grant O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81571819 O and O 81500766 B-AWARD and O by O the O grant O from O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG LQ19H120011 O and O by O the O Program B-ORG of I-ORG Zhejiang I-ORG Medical I-ORG Technology I-ORG 2019328715 O The O funding O bodies O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O the O writing O of O the O manuscript O This O work O was O supported O by O the O Special B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG for I-ORG Carbon I-ORG Peak I-ORG and I-ORG Carbon I-ORG Neutralization I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grant O No. O BE2022612 B-AWARD the O Ph.D B-ORG research I-ORG start-up I-ORG fund I-ORG 762140 O and O the O talent B-ORG cultivation I-ORG project I-ORG 2021xjxm032 O of O Anhui O Normal O University O The O Tasmania O Older O Adult O Cohort O was O funded O by O the O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG of I-ORG Australia I-ORG 302204 O the O Tasmanian B-ORG Community I-ORG Fund I-ORG D0015018 O the O Arthritis B-ORG Foundation I-ORG of I-ORG Australia I-ORG MRI06161 O and O the O University B-ORG of I-ORG Tasmania I-ORG Institutional I-ORG Research I-ORG Grants I-ORG Scheme I-ORG D0015019 O This O research O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O U1832165 B-AWARD 21902001 B-AWARD and O 22102001 B-AWARD Provincial B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Grant O No. O 2008085QB85 B-AWARD and O 2108085QB48 B-AWARD Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Anhui I-ORG Province I-ORG Grant O No. O 202004a05020015 B-AWARD and O 006233172019 B-AWARD and O Higher B-ORG Education I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Province I-ORG KJ2021A0027 O and O KJ2021A0029 B-AWARD This O study O was O funded O by O the O Health B-ORG Research I-ORG Council I-ORG of I-ORG New I-ORG Zealand I-ORG #13/584 O to O JMTH O the O Canterbury B-ORG Medical I-ORG Research I-ORG Foundation I-ORG #Lee_BUR2018-001 O to O SJL O and O Lottery B-ORG Health I-ORG Research I-ORG #352179 O to O SJL O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Funding O for O this O project O came O from O the O Technology B-ORG Innovation I-ORG Project I-ORG of I-ORG Hubei I-ORG Province I-ORG of I-ORG China I-ORG Major O Program O No. O 2019ABA108 O the O Science B-ORG and I-ORG Technology I-ORG Supporting I-ORG Program I-ORG of I-ORG Jiangxi I-ORG Province(20132BBF60018/20141BBF60014 O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Supporting I-ORG Program I-ORG No. O 2012BAD27B01 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities(2042015kf0244 O This O work O was O supported O by O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of O CAS O XDB29010300 O to O X.Z O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG 2020ZX09201-001 O to O D.-Y.Z O and O 2018ZX10101004 B-AWARD to O X.Z O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81971818 O and O 81772047 B-AWARD to O Y.S O 81873964 B-AWARD to O Y.Q O and O 31670161 B-AWARD to O X.Z O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 20720200013 O to O S-H.L O and O a O grant O from O Clinical B-ORG Research I-ORG Center I-ORG for I-ORG Anesthesiology I-ORG of I-ORG Hubei I-ORG Province I-ORG 2019ACA167 O This O work O was O supported O by O the O Strategic O Priority O Research O Program O of O the O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG grant O XDA19050301 B-AWARD the O Bureau B-ORG of I-ORG International I-ORG Cooperation I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG grants O 153211KYSB20160029 B-AWARD and O 153211KYSB20150010 B-AWARD the O National B-ORG Key I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG grants O 2017YFC1201202 B-AWARD 2016YFC1201303 B-AWARD and O 2016YFC0901702 B-AWARD the O 13th B-ORG Five-year I-ORG Informatization I-ORG Plan I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG grant O XXH13506 B-AWARD and O the O National B-ORG Science I-ORG Foundation I-ORG for I-ORG Young I-ORG Scientists I-ORG of I-ORG China I-ORG grant O 31701157 B-AWARD This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2021YFB3400902 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 51275414 B-AWARD No. O 51605387 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG with O Grant O No. O 3102015BJ B-AWARD II) I-AWARD ZS007 O the O Research B-ORG Fund I-ORG of I-ORG the I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Solidification I-ORG Processing I-ORG NWPU O China O Grant O No.130-QP-2015 O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shaanxi I-ORG Province I-ORG No. O 2020ZDLGY12-07 B-AWARD and O the O Tianshan B-ORG Innovative I-ORG Group’s I-ORG project I-ORG of I-ORG Xinjiang I-ORG Uygur I-ORG Autonomous I-ORG Region I-ORG No. O 2020D14041 B-AWARD The O research O was O supported O by O the B-ORG Program I-ORG of I-ORG Fishery I-ORG Problem I-ORG Tackling I-ORG of I-ORG Guangdong I-ORG Province I-ORG A201701B03 O the B-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2015B020231007 O and O 2017B030314052 O and O the B-ORG Strategic I-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDA13000000 O The O funders O had O no O role O in O the O design O of O the O study O and O collection O analysis O interpretation O of O data O nor O in O writing O the O manuscript O The O research O was O generously O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 81102036 B-AWARD the O Shanghai B-ORG Sailing I-ORG Program I-ORG 18YF1423000 O and O the O Foundation B-ORG for I-ORG Young I-ORG Scholars I-ORG of I-ORG Second I-ORG Military I-ORG Medical I-ORG University I-ORG 2017QN16 O 2917QN17 B-AWARD This O work O was O supported O in O part O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31171485 O and O 31470086 B-AWARD the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2014AA10A605 O and O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Supporting I-ORG Program I-ORG of I-ORG China I-ORG 2012BAD04B08 O and I-AWARD 2013BAD07B09 O Australian B-ORG Research I-ORG Council I-ORG ARC O DP200101948 O DP210103342 B-AWARD Defence B-ORG Research I-ORG and I-ORG Development I-ORG Organization I-ORG DRDO O DFTM/03/3203/M/01/JATC O Department B-ORG of I-ORG Atomic I-ORG Energy-Board I-ORG of I-ORG Research I-ORG in I-ORG Nuclear I-ORG Sciences I-ORG DAE-BRNS O 37(3)/14/01/2016-BRNS/37015 O European B-ORG Cooperation I-ORG in I-ORG Science I-ORG and I-ORG Technology I-ORG COST I-ORG Action I-ORG CA21159 B-AWARD and O Engineering B-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG EPSRC O UK) O EP/J002356/1 O EP/P021859/1 B-AWARD EP/T034246/1 B-AWARD This O work O was O supported O by O grants O from O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Taiwan I-ORG MOST O 111-2314-B-039-048-MY3 O China B-ORG Medical I-ORG University I-ORG CMU111-ASIA-04 O CMU111-ASIA-05 B-AWARD China B-ORG Medical I-ORG University I-ORG Hospital I-ORG DMR-111-108 O DMR-111-229 B-AWARD DMR-110-176 B-AWARD DMR-111-165 B-AWARD DMR-112-090 B-AWARD DMR-112-146 B-AWARD DMR-112-096 B-AWARD and O MacKay B-ORG Medical I-ORG College I-ORG MMC-RD-110-1B-P015 O MMC-RD-110-1B-P023 B-AWARD MMC-RD-111-1B-P010 B-AWARD MMC-RD-111-1B-P016 B-AWARD This O research O was O supported O by O the O Korea O Medical O Device O Development O Fund O funded O by O the O Korean B-ORG government I-ORG the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG ICT O the O Ministry O of O Trade O Industry O and O Energy O the O Ministry O of O Health O and O Welfare O and O the O Ministry O of O Food O and O Drug O Safety O Project O Number O 1711138281 B-AWARD KMDF_PR_20200901_0145 B-AWARD the O Bio O and O Medical O Technology O Development O Program O of O the O National O Research O Foundation O NRF O funded O by O the O Ministry O of O Science O and O ICT O 2022M3E5E9016506 O and O 2022M3C1A3096446 B-AWARD and O the O Korea B-ORG Institute I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG KIST O Institutional O Program O under O Project O 2E32341 B-AWARD The O authors O would O like O to O thank O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51673131 O 21643002 B-AWARD 51573215 B-AWARD the O Special O Project O on O the O Integration O of O Industry O Education O and O Research O of O Guangdong O Province O 2017B090901003 O 2016B010114004 O 2016A050503001 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2016A030313354 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG 2015J05030 O for O the O financial O support O of O this O work O This O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31760437 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Basic I-ORG Resources I-ORG Investigation I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2017FY100704 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangxi I-ORG Zhuang I-ORG Autonomous I-ORG Region I-ORG of I-ORG China I-ORG Grant O No. O 2017JJB130020 B-AWARD the O Guangxi B-ORG Education I-ORG Innovation I-ORG Program I-ORG for I-ORG Postgraduates I-ORG and I-ORG the I-ORG College I-ORG Student I-ORG Innovation-Venture I-ORG Training I-ORG Program I-ORG of I-ORG Guangxi I-ORG University I-ORG Grant O No. O YCSZ2012015 B-AWARD and O Study O Abroad O Program O for O Excellent O Ph.D O Students O of O Guangxi O Zhuang O Autonomous O Region O This O research O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos I-AWARD 11705122 O the B-ORG artificial I-ORG intelligence I-ORG key I-ORG laboratory I-ORG of I-ORG Sichuan I-ORG province I-ORG Foundation I-ORG 2017RYY02 O and O the B-ORG Project I-ORG of I-ORG Sichuan I-ORG provincial I-ORG science I-ORG and I-ORG Technology I-ORG Department I-ORG Grant O No. B-AWARD 2017JY0338 I-AWARD 2019YJ0477 I-AWARD 2018GZDZX0043),Enterprise O informatization I-ORG and I-ORG Internet I-ORG of I-ORG things I-ORG measurement I-ORG and I-ORG control I-ORG technology I-ORG key I-ORG laboratory I-ORG project I-ORG of I-ORG Sichuan I-ORG provincial I-ORG university I-ORG 2018WZY01 O Sichuan B-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Engineering I-ORG talent I-ORG introduction I-ORG project I-ORG 2017RCL53 O and O the B-ORG Project I-ORG of I-ORG Sichuan I-ORG Provincial I-ORG Academician I-ORG Expert I-ORG workstation I-ORG of I-ORG Sichuan I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Engineering(2018YSGZZ04 O And O the O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG Frontiers O in O Integrative O Biology O Research O Program O EF-0328698 O the O National B-ORG Aeronautics I-ORG and I-ORG Space I-ORG Administration I-ORG Exobiology O Program O NAG5-8807 O and O NX09AM87G B-AWARD and O the O U.S O Department O of O Energy O DOE O Office O of O Biological B-ORG and I-ORG Environmental I-ORG Research I-ORG BER O as O part O of O BER's O Genomic O Science O Program O GSP O This O contribution O originates O from O the O GSP O Foundational O Scientific O Focus O Area O FSFA O at O the O Pacific O Northwest O National O Laboratory O PNNL O contract O no. O 112443 B-AWARD It O was O also O supported O by O Montana B-ORG Agricultural I-ORG Experiment I-ORG Station I-ORG project O 911352 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 32072781 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation O grant O number O 2022M721651 B-AWARD and O Jiangsu B-ORG Agricultural I-ORG Industry I-ORG Technology I-ORG System O grant O number O JATS(2022)480 B-AWARD The O authors O acknowledge O Fundacão B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG Tecnologia I-ORG FCT)-FCT/MET I-ORG PIDDAC O under O the O Strategic O Program O UIDB/00645/2020 B-AWARD and O UIDP/00645/2020 B-AWARD of O IBEB B-ORG UIDB/04138/2020 B-AWARD and O UIDP/04138/2020 B-AWARD of O iMed.ULisboa B-ORG but O also O the O PhD B-ORG fellowship I-ORG UI/BD/150754/2020 B-AWARD This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O nos O 81773290 B-AWARD 81472315 B-AWARD and O 81872442 B-AWARD Guangdong B-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG 2017A030313497 O 2016A040403053 B-AWARD PLA B-ORG Logistics I-ORG Research I-ORG Project I-ORG of I-ORG China I-ORG CWH17L020 O 18CXZ030 O The O funding O bodies O played O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O study O was O obtained O by O Major B-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG for I-ORG Public I-ORG Welfare I-ORG of I-ORG Henan I-ORG Province I-ORG 201300110300 O Innovation B-ORG Demonstration I-ORG Special I-ORG Project I-ORG of I-ORG Henan I-ORG Province I-ORG 201111110100 O Henan B-ORG Provincial I-ORG Key I-ORG Science&Technology I-ORG Special I-ORG Project I-ORG 22110011070 O Central B-ORG Government I-ORG Guides I-ORG the I-ORG Local I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Special I-ORG Fund I-ORG Z20221341069 O Zhongyuan B-ORG Scholars I-ORG of I-ORG Henan I-ORG Province I-ORG in I-ORG China I-ORG No. O 192101510004 B-AWARD Zhongyuan B-ORG Scholar I-ORG Workstation I-ORG Funded I-ORG Project(ZYGZZ2020015 O 214400510015 B-AWARD Key B-ORG Project I-ORG Foundation I-ORG of I-ORG Natural I-ORG Science I-ORG Research I-ORG of I-ORG Universities I-ORG of I-ORG Henan I-ORG Province I-ORG in I-ORG China I-ORG 20A550004 O and O the O Program B-ORG for I-ORG Zhongyuan I-ORG Leading I-ORG Talents I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG in I-ORG Henan I-ORG Province I-ORG 204200510016 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O number O 82170369 B-AWARD the O Jilin B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Foundation I-ORG Grant O number O 20210509003RQ B-AWARD the B-ORG program I-ORG of I-ORG Chang I-ORG chun I-ORG science I-ORG and I-ORG technology I-ORG bureau I-ORG development I-ORG plan I-ORG project I-ORG Grant O number O 21ZY29 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32260029 O the O Applied B-ORG Basic I-ORG Research I-ORG Foundation I-ORG of I-ORG Yunnan I-ORG Province I-ORG 202101AT070266 O and O the O Postgraduate B-ORG Research I-ORG and I-ORG Innovation I-ORG Foundation I-ORG of I-ORG Yunnan I-ORG University I-ORG KC-22221839 O This O project O was O supported O by O grants O from O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH-1R15HL117238 O to O author O LX, O National B-ORG Center I-ORG for I-ORG Research I-ORG Resources O 5P20RR016471-12/8 B-AWARD P20 I-AWARD GM103442-12 I-AWARD to O authors O LX O and O KZ) O and O the O American B-ORG Heart I-ORG Association I-ORG 13SDG14650009 O to O author O LX O This O work O was O also O supported O by O USDA B-ORG Agricultural I-ORG Research I-ORG Service I-ORG Project O 3062-51000-052-00D O to O author O KJC O and O by O the O USDA O National O Institute O of O Food O and O Agriculture O Hatch O project O 1010406 O to O author O LX. O This O study O was O supported O by O grants O from O the O Chinese B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2016M592354 B-AWARD to O MP, O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31400875 B-AWARD to O QZ, O Open B-ORG Research I-ORG Fund I-ORG of I-ORG the I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Cognitive I-ORG Neuroscience I-ORG and I-ORG Learning I-ORG China O Grant O No. O CNLZD1604 B-AWARD to O QZ, O and O the O Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No. O CCNU18QN038 B-AWARD to O MP. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O present O research O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0201300 O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-29 O Jiangsu B-ORG Agricultural I-ORG Industry I-ORG Technology I-ORG System I-ORG JATS O 2017]274 O and O Jiangsu O Key O Agricultural O Project O for O New O Cultivars O Innovation O PZCZ201723 B-AWARD Part O of O this O study O was O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG NSF O grant O number O CHE-1411993 B-AWARD and O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH O grant O number O COBRE O P20GM103638 B-AWARD GC O received O support O from O the O American B-ORG Heart I-ORG Association-Midwest O Affiliate O Postdoctoral O Research O Fellowship O grant O number O NFP0075515 B-AWARD while O FC O received O support O from O the O Neuropsychopharmacology O Research O Program O 2017 O grant O number O RC-06-05 O The O APC O was O funded O by O Oasi O Research O Institute—IRCCS O This O work O was O conducted O as O part O of O a O SHRINE O Pilot O Grant O and O was O supported O by O Harvard B-ORG Catalyst I-ORG O The O Harvard O Clinical O and O Translational O Science O Center O National O Center O for O Research O Resources O and O the O National O Center O for O Advancing O Translational O Sciences O National B-ORG Institutes I-ORG of I-ORG Health I-ORG Award O UL1 B-AWARD TR001102 I-AWARD to O LST O and O financial O contributions O from O Harvard O University O and O its O affiliated O academic O healthcare O centers O and O in O part O by O the O Intramural O Research O Program O of O the O NIH O National B-ORG Institute I-ORG of I-ORG Environmental I-ORG Health I-ORG Sciences I-ORG Z01-ES103315 O to O NS) O and O the O Warren O Alpert O Medical O School O of O Brown O University O Summer O Assistantship O to O KB O NDS O is O supported O as O a O Lasker O Clinical O Research O Scholar O 1SI2ES025429-01 O to O NS O The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O National O Center O for O Research O Resources O the O National O Center O for O Advancing O Translational O Science O or O the O National O Institutes O of O Health O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 91129725,81572536 O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG 14140901700 O the O Joint O research O foundation O of O Shanghai O Shenkang O hospital O development O center O on O innovative O medical O technology O SHDC12015125 O Shanghai O Municipal O Education O Commission(15ZZ058 O Shanghai B-ORG Municipal I-ORG Education I-ORG Commission-Gaofeng I-ORG Clinical I-ORG Medicine I-ORG Grant I-ORG Support I-ORG 20152215 O Key O Disciplines O Group O Construction O Project O of O Pudong O Health O Bureau O of O Shanghai O PWZxq2014–05 O and O the O Shanghai O Jiao O Tong O University O School O of O Medicine O Translational O Research O Innovation O Fund O 15ZH4002 O This O work O was O funded O by O grants O from O the O Wellcome B-ORG Trust I-ORG 097720/Z/11/Z O the O Medical B-ORG Research I-ORG Council I-ORG MR/M023672/1 O and O the O Stroke B-ORG Association I-ORG TSA O 2014/02 O This O research O was O funded O by O the O Macau B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Fund I-ORG No. O 085/2017/A2 B-AWARD 0077/2019/AMJ B-AWARD 0032/2022/A1 B-AWARD the O University B-ORG of I-ORG Macau I-ORG Fund I-ORG No. O SRG2017-00097-FHS B-AWARD MYRG2019-00018-FHS B-AWARD 2020-00094-FHS B-AWARD and O the O Faculty B-ORG of I-ORG Health I-ORG Sciences I-ORG University I-ORG of I-ORG Macau I-ORG No. O FHSIG/SW/0007/2020P B-AWARD MOE O Frontiers O Science O Center O for O Precision O Oncology O pilot O grant O and O a O startup O fund O to O S.M.W O This O work O was O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81401281 O grants O for O scientific B-ORG research I-ORG of I-ORG BSKY I-ORG from I-ORG Anhui I-ORG Medical I-ORG University I-ORG xj201401 O grants O for O the B-ORG 4th I-ORG excellently I-ORG scientific I-ORG research I-ORG of I-ORG QNBJRC I-ORG from I-ORG Anhui I-ORG Medical I-ORG University I-ORG 2013500023 O The O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 31570071 B-AWARD 31971201 B-AWARD and O 31800665 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Development I-ORG Project I-ORG of I-ORG Shandong I-ORG Province I-ORG Grant O Nos O 2018GSF121002 B-AWARD and O 2018GHY115036 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG Grant O Nos O ZR2018BC013 B-AWARD and O ZR2019MD038 B-AWARD and O the O Taishan B-ORG Industry I-ORG Leading I-ORG Talents I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG Grant O No. O tscy20160311 B-AWARD This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2016YFC0104802 B-AWARD Grant O No. O 2016YFB0402704 B-AWARD Beijing B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG Grant O No. O D171100004617001 B-AWARD Jiangsu B-ORG Planned I-ORG Projects I-ORG for I-ORG Postdoctoral I-ORG Research I-ORG Funds I-ORG Grant O No.2019K053 O and O National B-ORG Natural I-ORG Science I-ORG Youth I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 11904233 B-AWARD This O study O was O supported O by O “13th B-ORG Five-Year I-ORG Plan” I-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG Supporting I-ORG Plan I-ORG 2015BAI12B04 O Beijing B-ORG Science I-ORG and I-ORG Technology I-ORG Supporting I-ORG PlanD16110000381605 O and O the O Beijing B-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospitals’ I-ORG Mission I-ORG Plan I-ORG SML20150501 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 61501526 B-AWARD 21804146 B-AWARD and O 22004134 B-AWARD the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG South-Central I-ORG Minzu I-ORG University I-ORG No. O CZQ22007 B-AWARD and O CPT22022 B-AWARD Wuhan B-ORG Qinji I-ORG Intelligent I-ORG Technology I-ORG Co I-ORG Ltd O HZY21073 O and O Wuhan B-ORG Jingshi I-ORG Telemetry I-ORG Technology I-ORG Co I-ORG Ltd O HZY22134 O This O study O was O supported O by O the B-ORG Shanghai I-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG grant O numbers O ZY3-LCPT-1-1010 B-AWARD and O 20174Y0038 B-AWARD the B-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipal I-ORG grant O number O 17ZR1428100 B-AWARD and O the B-ORG Youth I-ORG Science I-ORG and I-ORG Technology I-ORG Talent I-ORG Yang-fan I-ORG Project I-ORG of I-ORG Shanghai I-ORG grant O number O 17YF1417800 B-AWARD This O research O was O supported O by O the O Human B-ORG Frontier I-ORG Science I-ORG Program I-ORG HFSP O grant O RGP0019/2015 O by O the O Israel B-ORG Science I-ORG Foundation I-ORG ISF O grant O 1350/12 O and O by O the O Ministry B-ORG of I-ORG Science I-ORG Technology I-ORG and I-ORG Space I-ORG of O Israel O grant O 3-12068 O P.L.G.B O was O funded O by O the O FNR B-ORG of I-ORG Luxembourg I-ORG 6009110 O and O the O work O was O supported O by O the O Royal B-ORG Society I-ORG UF110155 O the O NERC B-ORG NE/K0060029/1 O and O Wellcome B-ORG 202769/Z/16/Z O Rodrigo O Costa O Araújo O was O supported O by O CNPq B-ORG 140039/2018-1 O CAPES B-ORG and I-ORG FAPEAM I-ORG provided I-ORG a I-ORG PhD I-ORG scholarship I-ORG Conservation I-ORG Leadership I-ORG Programme I-ORG F02304217 O Conservation B-ORG International’s I-ORG Margot I-ORG Marsh I-ORG Primate I-ORG Action I-ORG Fund I-ORG 6002856 O for O funding O fieldwork O and O CAPES/PRO-AMAZONIA/AUXPE B-ORG 3261/2013 O for O funding O fieldwork O and O labwork O to O NSF/FAPESP B-ORG “Dimensions I-ORG of I-ORG Biodiversity” I-ORG NSF O 1241066 I-AWARD and I-AWARD FAPESP I-AWARD 12/50260-6 O for O funding O laboratory O work O and O to O Idea O Wild O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81570264 O Programs B-ORG of I-ORG Young I-ORG and I-ORG Middle-Aged I-ORG Talent I-ORG Cultivation I-ORG of I-ORG Fujian I-ORG Provincial I-ORG Health I-ORG System I-ORG 2015-ZQN-ZD-18 O and O Fujian B-ORG Provincial I-ORG Medical I-ORG Innovation I-ORG Subject I-ORG 2014-CXB-12 O This O work O was O sponsored O in O part O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O nos O 81700534 B-AWARD the O scientific B-ORG research I-ORG plan I-ORG of I-ORG Jilin I-ORG Health I-ORG and I-ORG family I-ORG planning I-ORG commission I-ORG 2016G001 O the B-ORG Jilin I-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Plan I-ORG 20160520158JH O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG 2014ZX10002002 O and O the B-ORG Program I-ORG for I-ORG JLU I-ORG Science I-ORG and I-ORG Technology I-ORG Innovative I-ORG Research I-ORG Team I-ORG 2017TD-08 O This O work O was O supported O by O JST B-ORG CREST I-ORG ‘Cognitive O Mirroring’ O Grant O Number O JPMJCR16E2 B-AWARD MEXT B-ORG Grant-in-Aid O for O Scientific O Research O on O Innovative O Areas O ‘Constructive O developmental O science’ O Research O Project O Number O JP24119001 B-AWARD JP24119003 O and O JSPS B-ORG Grant-in-Aid O for O Specially O Promoted O Research O ‘Constructive O developmental O science’ O Research O Project O Numbers O JP24000012 B-AWARD The O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81870756 O the O Wuhan B-ORG Young I-ORG and I-ORG Middle-aged I-ORG Medical I-ORG Talents I-ORG Training I-ORG Program I-ORG No. O 2019 I-AWARD 87) O and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 2042018kf0129 B-AWARD Wuhan O University O This O work O was O supported O by O grants O from O the O Hungarian B-ORG National I-ORG Science I-ORG Fund I-ORG OTKA-K124862 O Grant O the O Hungarian B-ORG Academy I-ORG of I-ORG Sciences I-ORG Momentum O LP2014-7/2014 I-AWARD Grant O the O Hungarian O National O Research O Development O and O Innovation O Fund O FIEK_16-1-2016-0005 O Grant O and O from O the O European B-ORG Union I-ORG FP6 O Pregenesys-037244 I-AWARD Grant O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Meg O Osler O and O Andrew O Boulle O acknowledge O funding O from O the O Bill B-ORG and I-ORG Melinda I-ORG Gates I-ORG Foundation I-ORG 1164272 O Morna O Cornell O acknowledges O funding O from O the O US O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health I-ORG and O the O South O African O Medical O Research O Council O grant O number O R01MH106600 B-AWARD and O the O U.S O National O Institutes O of O Health’s O National B-ORG Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases O the O Eunice O Kennedy O Shriver O National O Institute O of O Child O Health O and O Human O Development O the O National O Cancer O Institute O the O National O Institute O of O Mental O Health O the O National O Institute O on O Drug O Abuse O the O National O Heart O Lung O and O Blood O Institute O the O National O Institute O on O Alcohol O Abuse O and O Alcoholism O the O National O Institute O of O Diabetes O and O Digestive O and O Kidney O Diseases O and O the O Fogarty O International O Center O under O Award O Number O U01AI069924 B-AWARD The O content O of O this O paper O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O funders O The O funding O bodies O played O no O role O in O the O conceptualization O or O in O writing O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51703178 O 81770728 I-AWARD 81570655 O the O Postdoctoral O Science O Foundation O of O Shaanxi O Province O 2016BSHEDZZ100 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2015M580855 O 2018T111057 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 2018JQ5053 O and O the O Fundamental O Research O Fund O for O the O Central O Universities O xjj2016084 O This O work O was O supported O by O the O projects O of O Korea B-ORG Institute I-ORG of I-ORG Machinery I-ORG and I-ORG Materials I-ORG KIMM O NK226D O This O work O was O also O supported O by O the O Korea B-ORG Medical I-ORG Device I-ORG Development I-ORG Fund O grant O 202012D19 O and O the O X-mind B-ORG Corps I-ORG program I-ORG of I-ORG the I-ORG NRF I-ORG NRF-2019H1D8A1109907 O funded O by O the O Korea O government O Ministry O of O Science O and O ICT O This O work O was O supported O by O the O Commonweal B-ORG Item I-ORG of I-ORG the I-ORG State I-ORG Oceanic I-ORG Administration I-ORG of I-ORG the I-ORG People’s I-ORG Republic I-ORG of I-ORG China I-ORG 201505033 O NSFC-Shandong B-ORG joint I-ORG Fund I-ORG U1606403 O Shandong B-ORG Province I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG 2016YYSP010 O and O Qingdao B-ORG People’s I-ORG Livelihood I-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG 16-6-2-41-nsh O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Forestry B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Project I-ORG the I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Center I-ORG of I-ORG State I-ORG Forestry I-ORG and I-ORG Grassland I-ORG Administration I-ORG KJZXSA2019041 O and O the O Science B-ORG and I-ORG Technology I-ORG Revitalization I-ORG Forestry I-ORG Project I-ORG of I-ORG Henan I-ORG Provincial I-ORG Department I-ORG of I-ORG Forestry I-ORG 2018(68 O and O the O Dabie B-ORG Mountain I-ORG Forestry I-ORG Resources I-ORG Innovation I-ORG Theory I-ORG and I-ORG Technology I-ORG innovation I-ORG team I-ORG of I-ORG Xinyang I-ORG Agriculture I-ORG and I-ORG Forestry I-ORG University I-ORG XNKJTD-004 O This O work O was O supported O by O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 21133002 O Shenzhen B-ORG Peacock I-ORG Program I-ORG JCYJ20140509093817689 O and O Nanshan B-ORG District I-ORG KC2014ZDZJ0026A O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shaanxi I-ORG Province I-ORG China I-ORG 2018TSCXL-NY-05-01 O and O the B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Xi’an I-ORG China I-ORG 201806113YF01NC09 O 3 O and O Major B-ORG Projects I-ORG for I-ORG Industrial I-ORG Academic I-ORG and I-ORG Research I-ORG Collaborative I-ORG Innovation I-ORG of I-ORG Yangling I-ORG Demonstration I-ORG Zone I-ORG 2018CXY-08 O The O funders O had O no O role O in O the O experiment O design O data O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 82272661 B-AWARD Liaoning B-ORG key I-ORG special I-ORG project I-ORG of I-ORG science I-ORG and I-ORG technology I-ORG No. O 2022JH1/10800070 B-AWARD and O the O 345 B-ORG Talent I-ORG Project I-ORG Category I-ORG 30C I-ORG of I-ORG the I-ORG Shengjing I-ORG Hospital I-ORG of I-ORG China I-ORG Medical I-ORG University I-ORG No. O 14 B-AWARD to O Dandan O Wang O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81771993 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC1101400 O the O Shanghai B-ORG Collaborative I-ORG Innovation I-ORG Program I-ORG on I-ORG Regenerative I-ORG Medicine I-ORG and I-ORG Stem I-ORG Cell I-ORG Research I-ORG 2019CXJQ01 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG 16ZR1419800 O The O funder O had O no O role O in O the O data O collection O data O management O data O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31571730 O 31401440 B-AWARD 31771863,http://www.nsfc.gov.cn B-AWARD and O was O supported O by O an O earmarked O fund O for O Modern B-ORG Agriculture I-ORG Technology I-ORG of I-ORG China I-ORG CARS-170106 O This O project O was O also O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG of I-ORG China I-ORG 2015A030310286 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O manuscript O preparation O Research B-ORG Council I-ORG of I-ORG Lithuania I-ORG MIP–107/2010 O to O G. O Tamulaitis O MIP-41/2013 O to O G. O Tamulaitiene O Polish B-ORG National I-ORG Science I-ORG Centre I-ORG NCN O UMO-2011/02/A/NZ1/00052 O UMO-2014/13/B/NZ1/03991 B-AWARD UMO-2014/14/M/NZ5/00558 B-AWARD to O M.B O access O to O beamline O I911-3 O MaxLAB O Lund O Sweden O was O funded O by O European O Community’s O Seventh B-ORG Framework I-ORG Programme I-ORG FP7/2007-2013 O under O BioStruct-X O grant O agreement O N°283570 O Funding O for O open O access O charge O Research O Council O of O Lithuania O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81860150 O Special B-ORG Project I-ORG on I-ORG Innovation I-ORG Driven I-ORG Development I-ORG of I-ORG Guangxi I-ORG Guike-AA17204029 O and O Guike-AA18118050 O National B-ORG Modern I-ORG Agricultural I-ORG Industrial I-ORG Technology I-ORG System I-ORG nycytxgxcxtd-15-01 O Science B-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG Guangxi I-ORG Guike-AA17292002 O and O Guangxi B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Program I-ORG 2017GXNSFBA198157 O and O 2018GXNSFAA294038 O This O work O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O contract O 61674027 B-AWARD in O part O by O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Funded I-ORG Project I-ORG under O Grant O 2017M612942 B-AWARD and O in O part O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG under O grant O 2016A030311022 B-AWARD and O 2018A030310015 B-AWARD in O part O by O the O Applied B-ORG Fundamental I-ORG Research I-ORG Project I-ORG of I-ORG Sichuan I-ORG Province I-ORG under O grant O 18YYJC0482 B-AWARD and O in O part O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG under O grant O ZYGX2016J210 B-AWARD This O study O was O supported O by O grants O from O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grants O No O BK20171484 B-AWARD the O Project O of O Invigorating O Health O Care O through O Science O Technology O and O Education O Jiangsu O Provincial O Medical O Youth O Talent O QNRC2016856 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81672896 B-AWARD the B-ORG Summit I-ORG of I-ORG the I-ORG Six I-ORG Top I-ORG Talents I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG 2017-WSN-179 O the O Postgraduate O Research O O Practice O Innovation O Program O of O Jiangsu O Province O KYCX18_1483 O the B-ORG Priority I-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG JX10231801 O Postgraduate O Research O O Practice O Innovation O Program O of O Jiangsu O Province O No. O KYCX18_1482 O The O Natural O Science O Foundation O of O China O 81874230 O and O the O Jiangsu O Social O Development O Project O BE2018726 O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31770617 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017A030310147 O and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2018PY13 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2019TQ0102 O and O National O Program O for O Support O of O Top-notch O Young O Professionals O This O research O was O funded O by O HGF B-ORG grant O no. O VH-NG-802 B-AWARD to O D.J O and O I.W O as O well O as O SPP B-ORG 1158 I-ORG DFG I-ORG grant O no. O BO B-AWARD 1776/12-1 I-AWARD to O I.W O S.H.F O acknowledges O financial O support O from O the O Ramón B-ORG y I-ORG Cajal I-ORG Research I-ORG Grant O RYC-2012-12167 B-AWARD of O the O Ministry O of O Economy O and O Competitiveness O of O Spain O This O work O was O supported O by O “Progetto O accordo I-ORG quadro I-ORG Regione I-ORG Lombardia-Università I-ORG lombarde” O ADPQ B-AWARD SAL31 I-AWARD ID I-AWARD 17292 I-AWARD to O LL; O Dote B-ORG di I-ORG Ricerca I-ORG FSE I-ORG Regione I-ORG Lombardia I-ORG to O EAC O ID O project I-AWARD 16304 O and O Fondazione B-ORG Nando I-ORG Peretti I-ORG Project O Number I-AWARD 2007-14 O This O study O is O funded O by O NIH B-ORG funding I-ORG EY025383 O EY012601 B-AWARD EY028037 B-AWARD and O EY028858 B-AWARD to O M.B.G O Research O to O Prevent O Blindness O unrestricted O grant O awarded O to O the O Department B-ORG of I-ORG Ophthalmology I-ORG and I-ORG Visual I-ORG Sciences I-ORG at O UAB O The O project O described O was O supported O by O the O NIH B-AWARD S10RR026887 I-AWARD instrumentation O grant O P30EY003039 B-AWARD core O grant O from O the O National B-ORG Eye I-ORG Institute O and O P30DK079626 B-AWARD core O grant O from O the O NIDDKD B-ORG We O would O like O to O thank O the O Nature B-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province I-ORG of I-ORG China I-ORG Grant O No. O 201602702 B-AWARD Shenyang O Science O Project O financed O by O Shenyang B-ORG Technology I-ORG Council I-ORG Grant O No. O 17-231-1-40 B-AWARD and O the O Young O and O Middle-aged O Career O Development O Planning O of O Shenyang B-ORG Pharmaceutical I-ORG University I-ORG Grant O No. O ZQN2016012 O We O express O sincere O gratitude O to O researchers O of O the O International O Medical O University O IMU O http://www.imu.edu.my/imu O Institute O for O Research O Development O and O Innovation O IRDI O especially O to O Center O for O Cancer O and O Stem O Cell O Research O for O the O insightful O scientific O discussions O This O work O was O funded O by O the O IMU B-ORG BMedSci I-ORG Research I-ORG Training I-ORG Program I-ORG BMS O I01/2015 O for O HCS O KHL O was O granted O an O Early B-ORG Career I-ORG Research I-ORG and I-ORG Knowledge I-ORG Transfer I-ORG Award I-ORG provided I-ORG by I-ORG the I-ORG University I-ORG of I-ORG Nottingham I-ORG in I-ORG 2011 I-ORG A2RHF1 O http://www.nottingham.edu.my/index.aspx O which O supported O the O plant O collection O extraction O and O isolation O work O VAY O was O a O recipient O of O the O postgraduate O scholarship O from O the O Ministry B-ORG of I-ORG Higher I-ORG Education I-ORG Malaysia I-ORG from O 2013-2015 B-AWARD https://www.mohe.gov.my/en O This O work O is O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O Nos O 2016YFC1305800 B-AWARD 2016YFC1305805 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31670724 B-AWARD and O the O startup O grant O of O Huazhong B-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Grant O No. O 3004012104 B-AWARD This O work O was O supported O by O theMedical O Research I-ORG Council[MC_UU_12017/13 O MC_UU_12017/15 B-AWARD and O theChief O Scientist I-ORG Office I-ORG of I-ORG the I-ORG Scottish I-ORG Government[SPHSU13 O SPHSU15 B-AWARD SVK O was O supported O by O aNRS O Senior I-ORG Clinical I-ORG Fellowship(SCAF/15/02 O The O funding O sources O had O no O involvement O in O study O design O in O the O collection O analysis O and O interpretation O of O data O in O the O writing O of O the O report O and O in O the O decision O to O submit O the O article O for O publication O This O work O was O supported O by O grants O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81330035 B-AWARD Medical B-ORG and I-ORG Health I-ORG Research I-ORG Foundation I-ORG of I-ORG Nanjing I-ORG Military I-ORG Command I-ORG No. O 12MA082 B-AWARD and O National B-ORG Key I-ORG Technology I-ORG Support I-ORG Program I-ORG from I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2015BAI12B11 O This O research O was O funded O by O project O EXPL/BAA-GR/0663/2021—Kiwi4Health—Exploring B-AWARD the I-ORG Eco-Innovative I-ORG Re-Use I-ORG of I-ORG Kiwiberry O supported O by O national O funds O by O FCT/MCTES B-ORG and O by O the O projects O UIDB/50006/2020 B-AWARD and O UIDP/50006/2020 B-AWARD through O national O funds O This O work O was O also O financed O by O national O funds O from O FCT—Fundação B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG a I-ORG Tecnologia I-ORG I.P O in O the O scope O of O the O project O UIDP/04378/2020 B-AWARD and O UIDB/04378/2020 B-AWARD of O the O Research O Unit O on O Applied O Molecular O Biosciences—UCIBIO O and O the O project O LA/P/0140/2020 B-AWARD of O the O Associate B-ORG Laboratory I-ORG Institute I-ORG for I-ORG Health I-ORG and I-ORG Bioeconomy—i4HB I-ORG This O study O is O funded O by O Collaborative B-ORG Innovation I-ORG Program I-ORG of I-ORG Hong I-ORG Kong I-ORG and I-ORG Guangdong I-ORG Province O the O Guangdong O Science O and O Technique O Department O 2016A050503032 O 2014A020212689 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC1301700 O and O the B-ORG Science I-ORG Technology I-ORG and I-ORG Innovation I-ORG Committee I-ORG of I-ORG Shenzhen I-ORG for I-ORG Research I-ORG Projects I-ORG JCYJ20151030151431727 O The O authors’ O research O was O supported O by O grants O from O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III I-ORG ISCIII I-ORG I-ORG Feder I-ORG PI20/00926 O and O co-funded O by O European B-ORG Union I-ORG ERDF/ESF O “Investing O in O your O future” O Gerencia B-ORG Regional I-ORG de I-ORG Salud I-ORG GRS2314/A/2021 O GRS2551/A/22 B-AWARD Fundación B-ORG SéNeCa I-ORG 21920/PI/22 O Fundación B-ORG Mutua I-ORG Madrileña I-ORG FMM O AP172142019 B-AWARD Sociedad B-ORG Española I-ORG de I-ORG Trombosis I-ORG y I-ORG Hemostasia I-ORG SETH-FETH O Ayuda O a O Grupos O de O Trabajo O en O Patología O Hemorrágica O 2021 O and O the O European B-ORG Commission I-ORG H2020-FETOPEN-1-2016-2017-SilkFusion O ID O 767309 O A.M.Q O is O fully O supported O by O a O postdoctoral O grant O from O Sociedad O Española O de O Hematología O y O Hemoterapia O SEHH-FEHH O 2022 O The B-ORG Scientific I-ORG Foundation I-ORG of I-ORG Institute I-ORG of I-ORG Psychology O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG E0CX121008 O E2CX3715CX B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61673374 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O work O reported O herein O was O supported O by O grants O from O the B-ORG Sichuan I-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG 2014SZ0038 O to O S O Yang O the B-ORG Young I-ORG Scholar I-ORG Creation I-ORG Projects I-ORG for I-ORG Sichuan I-ORG Province I-ORG Medical I-ORG Research I-ORG Q14054 O to O S O Yang O and O the B-ORG National I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81600819 O to O LJ O Guo O This O project O was O supported O by O the O Key B-ORG Research I-ORG Project I-ORG of I-ORG the I-ORG Shennong I-ORG Laboratory I-ORG SN01-2022-05 O the O Scientific B-ORG Studio I-ORG of I-ORG Zhongyuan I-ORG Scholars I-ORG 30601985 O Major B-ORG Projects I-ORG of I-ORG Henan I-ORG Province I-ORG 221100110200 O and O the O Special B-ORG Fund I-ORG for I-ORG Genetic I-ORG Breeding I-ORG Post I-ORG of I-ORG National I-ORG Laying I-ORG Hens I-ORG Industrial I-ORG Technology I-ORG System I-ORG NO. O CARS-40-K04 O This O research O is O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Tianjin I-ORG City I-ORG 16JCQNJC11900 O Key B-ORG Project I-ORG of I-ORG Tianjin I-ORG Health I-ORG Care I-ORG Professionals I-ORG 16KG166 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81771589 O and O The B-ORG Program I-ORG of I-ORG Tianjin I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG 18ZXDBSY00170 O None O of O the O funding O bodies O played O any O role O in O the O design O of O the O study O or O the O collection O analysis O or O interpretation O of O data O nor O in O writing O of O the O manuscript O This O work O was O funded O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O U1402261 O the O Infective B-ORG Diseases I-ORG Prevention I-ORG and I-ORG Cure I-ORG Project I-ORG of I-ORG China I-ORG No. O 2012ZX10004219 O and O the O National B-ORG Key I-ORG Technology I-ORG Support I-ORG Program I-ORG No. O 2014BAI13B01 O This O study O was O supported O by O Guangzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG project I-ORG No. O 201710010107 B-AWARD Guangdong B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG No. O 2016A020226011 B-AWARD and O Joint O Innovation B-ORG Specific I-ORG Project I-ORG in I-ORG Key I-ORG Areas I-ORG from I-ORG Guangdong I-ORG Branch I-ORG Institute I-ORG of I-ORG China I-ORG Academy I-ORG of I-ORG Chinese I-ORG Medical I-ORG Sciences I-ORG No. O ZZ0908065 B-AWARD This O project O was O sponsored O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31771017 O 31972924 O 31900941 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG 16441908700 O the O Innovation B-ORG Research I-ORG Plan I-ORG supported I-ORG by I-ORG Shanghai I-ORG Municipal I-ORG Education I-ORG Commission I-ORG ZXWF082101 O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0110700 O 2019YFC0120600 O and O the O Interdisciplinary O Program O of O Shanghai B-ORG Jiao I-ORG Tong I-ORG University I-ORG ZH2018QNA06 O YG2017MS09 O This O work O was O financed O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31670617 O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2022C02022 O and O Zhejiang B-ORG High-level I-ORG Talents I-ORG Special I-ORG Support I-ORG Program I-ORG 2020R52026 O This O research O was O funded O by O the O Department B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Sichuan I-ORG Province O grant O number O 2019YJ0338 B-AWARD the O Doctoral O Scientific O Research O Funds O of O China B-ORG West I-ORG Normal I-ORG University O grant O number O 17E077 B-AWARD and O 17E074 B-AWARD the O Fundamental O Research O Funds O of O China O West O Normal O University O grant O number O 18B030 B-AWARD and O CXTD2017-4 B-AWARD and O the O Chongqing B-ORG Research I-ORG Program I-ORG of I-ORG Basic I-ORG Research I-ORG and I-ORG Frontier I-ORG Technology O grant O number O cstc2018jcyjAX0238 B-AWARD This O work O was O supported O by O grants O from O the O Scientific O research O foundation O for O the O introduced O talents O of O Guangxi B-ORG Minzu I-ORG University I-ORG 2018KJQD14 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U20A2064 O Innovation-driven B-ORG development I-ORG special I-ORG fund I-ORG project I-ORG of I-ORG Guangxi I-ORG AA17204044 O Innovation O team O fund O project O of O young O Xiangsi O Lake O scholars O of O Guangxi O Minzu O University O 2018RSCXSHQN02 O and O Shandong B-ORG Provincial I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Programs I-ORG 2019JZZY020710 O This O research O was O supported O by O the O Basic O Science O Research O Program O of O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O funded O byof O the O Ministry O of O Education O Science O and O Technology O 2014R1A1A3053168 O the O Korea B-ORG Healthy I-ORG Industry I-ORG Development I-ORG Institute I-ORG KHIDI O of O the O Ministry O of O Health O O Welfare O HI14C0072 O Republic O of O Korea O HI14C0072 O and O Hallym B-ORG University I-ORG Research O Fund O 2014 O HRF-201403-015 O Republic O of O Korea O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O Fundação B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG a I-ORG Tecnologia I-ORG FCT-MCTES I-ORG Radiation I-ORG Biology I-ORG and I-ORG the I-ORG Biophysics I-ORG Doctoral I-ORG Training I-ORG Programme I-ORG RaBBiT O PD/00193/2012 B-AWARD UIDB/04378/2020 B-AWARD Applied O Molecular I-ORG Biosciences I-ORG Unit-UCIBIO O UIDB/00068/2020(CEFITEC B-AWARD Unit O UIDB/04559/2020 B-AWARD LIBPhys O UIDP/04559/2020 O LIBPhys O UIDB/50025/2020 B-AWARD Cenimat/i3N O and O the O scholarship O grant O number O PD/BD/142829/2018 B-AWARD to O T.P.P O from O the O RaBBiT B-ORG Doctoral I-ORG Training I-ORG Programme I-ORG This O work O was O supported O by O the O Wellcome B-ORG Trust I-ORG grant O number O 098051 B-AWARD to O N. O R. O T. O Malawi-Liverpool-Wellcome O Trust O Clinical O Research O Programme O is O supported O by O the O Wellcome O Trust O Major O Overseas O Programme O Core O Grant O number O 101113/Z/13/E O P. O M. O was O funded O by O National O Institutes O of O Health O through O the O H3Africa O Bioinformatics O Network O H3ABioNet O grant O number O U41HG006941 B-AWARD in O form O of O a O PhD O studentship O A. O E. O M. O is O supported O by O the O Quadram O Institute O Bioscience O BBSRC O funded O Strategic O Programme O Microbes O in O the O Food O Chain O project O number O BB/R012504/1 O and O Food B-ORG Standards I-ORG Fellowship I-ORG FS101185 B-AWARD This O work O was O funded O byNational O Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences10.13039/100000057grantGM008322;National O Institute I-ORG of I-ORG Neurological I-ORG Disorders I-ORG and I-ORG Stroke10.13039/100000065grantNS076752;National O Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute10.13039/100000050grantHL144047 O This O work O was O supported O by O the B-ORG 13th I-ORG Five-Year I-ORG State I-ORG Key I-ORG Development I-ORG Program I-ORG Grant O Number O 2016YFD0501310 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Number O 31272606 B-AWARD Science B-ORG Program I-ORG of I-ORG General I-ORG Administration I-ORG of I-ORG Quality I-ORG Supervision I-ORG Inspection I-ORG and I-ORG Quarantine I-ORG of I-ORG P.R.C I-ORG Program O Number O 2016IK030 B-AWARD and O Science B-ORG Program I-ORG of I-ORG Fujian I-ORG Entry-Exit I-ORG Inspection I-ORG and I-ORG Quarantine I-ORG Bureau I-ORG of I-ORG P.R.C I-ORG Program O Number O FJ2015-JS002 B-AWARD This O research O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFA0505500 O the O Strategic O Priority O Research O Program O of O the O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG XDB13040700 O the O Major O Program O of O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81330084 O the O National O Natural O Science O Foundation O of O China O 81503478 O 81473443 B-AWARD and O 31771476 B-AWARD the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG China I-ORG 2012ZX10005001-004 O the O Yang O Fan O Program O of O Shanghai B-ORG Committee I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Fund O Annotation O 14YF1411400 O and O 18YF1420700 B-AWARD and O E-Institutes B-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Education I-ORG Commission I-ORG E03008 O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD1000101 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31871269 O 31571351 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2662017PY043 O Authors O are O very O thankful O to O these O organizations O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 52009096 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2022T150498 B-AWARD and O Hubei B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 2022CFD165 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81700553 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2017M183789 B-AWARD and O the O Science B-ORG Fund I-ORG for I-ORG Creative I-ORG Research I-ORG Groups I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81121002 B-AWARD This O study O was O financially O supported O by O the O National B-ORG Key I-ORG Research I-ORG I-ORG Development I-ORG Plan I-ORG of I-ORG China I-ORG 2017YFC0504902 O Research O Fund I-ORG for I-ORG Excellent I-ORG Dissertation I-ORG of I-ORG China I-ORG Three I-ORG Gorges I-ORG University I-ORG 2020BSPY003 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41807068 O the O CRSRI B-ORG Open I-ORG Research I-ORG Program I-ORG CKWV2018488/KY O and O the O open O fund O of O Key B-ORG Laboratory I-ORG of I-ORG Geological I-ORG Hazards I-ORG on I-ORG Three I-ORG Gorges I-ORG Reservoir I-ORG Area I-ORG Ministry I-ORG of I-ORG Education I-ORG China O Three O Gorges O University O 2018KDZ06 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Rutgers B-ORG University I-ORG TechAdvance I-ORG Fund I-ORG FP10535 O the O New B-ORG Jersey I-ORG Commission I-ORG on I-ORG Brain I-ORG Injury I-ORG Research I-ORG CBIR16PIL015 O CBIR14FEL004 B-AWARD the O NIH B-ORG Biotechnology I-ORG Training I-ORG Program I-ORG NIH O T32 I-AWARD GM008339 O the O New B-ORG Jersey I-ORG Health I-ORG Foundation I-ORG PC O 123-22 O the O New B-ORG Jersey I-ORG Commission I-ORG on I-ORG Cancer I-ORG Research I-ORG COCR22PRF002 O the O National B-ORG Science I-ORG Foundation I-ORG REU I-ORG in O Cellular O Bioengineering O From O Biomaterials O to O Stem O Cells O NSF O EEC I-AWARD 1262924 O and O the O Graduate B-ORG Assistance I-ORG in I-ORG Areas I-ORG of I-ORG National I-ORG Need I-ORG GAAANN I-ORG Fellowship I-ORG DoEd O No. I-AWARD P200A150131 O This O work O was O supported O by O the O National B-ORG Transgenic I-ORG Project I-ORG of I-ORG China I-ORG 2016ZX08006-001 O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG ASTIP-IAS05 O and O Safety B-ORG Evaluation I-ORG Project I-ORG of I-ORG Transgenic I-ORG Animals I-ORG and I-ORG Feeding I-ORG Materials I-ORG 2011-G11 O to O LK. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Economic B-ORG and I-ORG Social I-ORG Research I-ORG Council I-ORG grant O number O ES/N000404/1 B-AWARD to O J.T.B O Medical B-ORG Research I-ORG Council I-ORG Project O grant O number O MR/L01999X/1 B-AWARD to O K.S.S O grant O number O MR/N013700/1 B-AWARD and O King’s O College O London O member O of O the O MRC O Doctoral O Training O Partnership O in O Biomedical O Sciences O A.Vic. O and O the O Academy B-ORG of I-ORG Finland I-ORG grant O number O 297908 B-AWARD to O M.O O The O TwinsUK O study O was O funded O by O the O Wellcome O Trust O European O Community’s O Seventh O Framework O Programme O FP7/2007–2013 O National O Institute O for O Health O Research O NIHR)-funded O BioResource O Clinical O Research O Facility O and O Biomedical O Research O Centre O based O at O Guy’s O and O St O Thomas’ O NHS O Foundation O Trust O in O partnership O with O King’s O College O London O SNP O genotyping O was O performed O by O The O Wellcome O Trust O Sanger O Institute O and O National O Eye O Institute O via O NIH/CIDR O The O Finnish O twin O study O was O funded O by O the O Academy O of O Finland O grant O numbers O 266286 B-AWARD 272376 I-AWARD 314383 O Helsinki O University O Central O Hospital O The O University O of O Helsinki O Research O Funds O Novo O Nordisk O Foundation O Ane O and O Signe O Gyllenberg O Foundation O Finnish O Diabetes O Research O Foundation O Finnish O Foundation O for O Cardiovascular O Research O The O funding O bodies O did O not O impact O the O design O of O the O study O analysis O and O interpretation O of O data O and O writing O of O the O manuscript O The O financial O support O of O this O research O was O provided O by O the O Priority O Academic O Program O Development O PAPD O of O Jiangsu O Higher O Education O Institutions O the O Aid B-ORG project I-ORG for I-ORG PhD I-ORG faculties I-ORG in I-ORG Jiangsu I-ORG Normal I-ORG University I-ORG 13XLR007 O the O National O Nature O Science O Foundation O of O China O Project O number O 31300067 O the O Xuzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG KC14N0068 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31671944 O 31301585 B-AWARD and O the O Qing O Lan O Project O of O Jiangsu O Province O Collections O of O the O Chinese O Longitudinal O Healthy O Longevity O Surveys O CLHLS O datasets O analyzed O in O this O paper O were O jointly O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC2000400 O National B-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG of I-ORG China I-ORG 72061137004 O and O the O United B-ORG States I-ORG National I-ORG Institute I-ORG of I-ORG Aging/National I-ORG Institute I-ORG of I-ORG Health I-ORG P01AG031719 O The O funding O agency O had O no O role O in O the O design O of O the O study O in O the O collection O analysis O or O interpretation O of O the O data O in O writing O or O approving O the O manuscript O or O in O the O decision O to O submit O the O manuscript O for O publication O This O project O received O funding O from O the O National B-ORG Science I-ORG Foundation I-ORG grants O GRFP B-AWARD 1329626 I-AWARD ‘Ale‘alani O Dudoit O Sea B-ORG Grant I-ORG O NA14OAR4170071 B-AWARD ‘Ale‘alani O Dudoit O NSF B-ORG grant O OCE#12-60169 B-AWARD DGE-1329626 B-AWARD Richard O Coleman O OCE#15-22572 B-AWARD Matthew O Iacchei O the O NOAA O Dr. O Nancy O Foster O Scholarship O under O award O number O NA15NOS4290067 O Richard O Coleman O National B-ORG Marine I-ORG Sanctuaries I-ORG NWHICRER-HIMB I-ORG partnership I-ORG MOA-2005-008/6882 O Papahānaumokuākea B-ORG Marine I-ORG National I-ORG Monument I-ORG O MOA-2009-039/7932 B-AWARD DIPnet O NSF-DEB#14-57848 O Further O support O was O provided O by O the O Carol O Ann O O Myron O K. O Hayashida O Scholarship O Lord O Scholarship O Maile O Goo O and O the O STAR O Foundation O Science O Technology O Scholarship O and O the O Hūlili O program O who O assisted O ‘Ale‘alani O Dudoit O during O this O project O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O by O the B-ORG National I-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81872714 B-AWARD the B-ORG Shanxi I-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Major I-ORG Diseases I-ORG Risk I-ORG Assessment I-ORG Grant O No. O 201805D111006 B-AWARD and O the B-ORG General I-ORG Program I-ORG for I-ORG Young I-ORG Scholar I-ORG of I-ORG Shanxi I-ORG Province I-ORG Grant O No. O 201801D221423 B-AWARD This O work O was O funded O by O the O National O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81400162 O 81570174 I-AWARD to O PX O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20140100 O to O PX O the B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Program I-ORG of I-ORG Nanjing I-ORG 201402066 O to O BC O the O Medical B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Program I-ORG of I-ORG Nanjing I-ORG Ykk14069 O to O BC) O and O the O Technique I-ORG Development I-ORG Foundation I-ORG of I-ORG Nan I-ORG Jing I-ORG Outstanding O Youth O Foundation O JQX15004 B-AWARD to O PX O These O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81473764,81273824 B-AWARD Key B-ORG Program I-ORG of I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG of I-ORG China I-ORG ZD O 201204 O Doctoral B-ORG Fund I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG 20102327110003 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 51975489 B-AWARD the O Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Program O grant O number O 2019YFH0094 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities O grant O number O 2682020CX29 B-AWARD This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD500706 O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG JCQY201906 O the O National B-ORG Natural I-ORG Science I-ORG Grant I-ORG of I-ORG P. I-ORG R. I-ORG China I-ORG No. O 31702197 O the O Fundamental O Research O Funds O for O the O Central O Universities O KJQN2018034 O and O A B-ORG Project I-ORG Funded I-ORG by I-ORG the I-ORG Priority I-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O Independent B-ORG Innovation I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG CX O 13)5035 O This O research O is O supported O by O the O following O funds O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81860325 O the B-ORG High-level I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Technical I-ORG Personnel I-ORG Training I-ORG Project I-ORG of I-ORG Yunnan I-ORG Province I-ORG No. O 2017006 O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG for I-ORG Precision I-ORG Medicine I-ORG No. O 2017FYC0907902 O This O work O was O supported O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81873486 O the B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province-Clinical I-ORG Frontier I-ORG Technology I-ORG BE2022754 O Clinical B-ORG Medicine I-ORG Expert I-ORG Team I-ORG Class I-ORG A) I-ORG of I-ORG Jinji I-ORG Lake I-ORG Health I-ORG Talents I-ORG Program I-ORG of I-ORG Suzhou I-ORG Industrial I-ORG Park I-ORG SZYQTD202102 O Suzhou B-ORG Key I-ORG Discipline I-ORG for I-ORG Medicine I-ORG SZXK202129 O Demonstration B-ORG of I-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG Project I-ORG SKY2021002 O Suzhou B-ORG Dedicated I-ORG Project I-ORG on I-ORG Diagnosis I-ORG and I-ORG Treatment I-ORG Technology I-ORG of I-ORG Major I-ORG Diseases I-ORG LCZX202132 O and O Research B-ORG on I-ORG Collaborative I-ORG Innovation I-ORG of I-ORG medical I-ORG engineering I-ORG combination I-ORG SZM2021014 O The O funders O had O no O roles O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O by O Tryg B-ORG Foundation I-ORG grant O number O 107632 B-AWARD Foundation B-ORG of I-ORG Public I-ORG Health I-ORG in I-ORG the I-ORG Middle I-ORG grant O number O 1-30-72-141-12 B-AWARD and O Aase B-ORG and I-ORG Ejnar I-ORG Danielsen’s I-ORG foundation I-ORG grant O number O 10-001233 B-AWARD The O foundations O played O no O role O in O the O design O execution O analysis O and O interpretation O of O data O or O writing O of O the O study O The O authors O gratefully O acknowledge O the O support O from O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51979045 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2022A1515011562 O and O Guangdong B-ORG Provincial I-ORG Special I-ORG Fund I-ORG for I-ORG promoting I-ORG high-quality I-ORG economic I-ORG development I-ORG GDNRC O 2021]56 I-AWARD Yuerong I-AWARD Office I-AWARD Letter I-AWARD 2020]161 O This O work O was O supported O by O Shandong B-ORG Provential I-ORG Natural I-ORG Science I-ORG Foundtion I-ORG No. O ZR2016CM23 B-AWARD the B-ORG Young I-ORG Talents I-ORG Training I-ORG program I-ORG of I-ORG Shandong I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG 2016-2018 O the O Major B-ORG in I-ORG Shandong I-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG 2015ZDJS03001-2 O the B-ORG Shandong I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2016ZDJS10A03-05 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31401310 B-AWARD The O funders O had O no O role O in O study O design O data O collection O analysis O and O interpretation O and O manuscript O writing O This O research O was O funded O in O part O by O the O Grant B-ORG Agency I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG the I-ORG Education I-ORG Science I-ORG Research I-ORG and I-ORG Sport I-ORG of I-ORG the I-ORG Slovak I-ORG Republic I-ORG VEGA O 1/0653/19 O VEGA B-AWARD 1/0539/21 I-AWARD and O VEGA B-AWARD 1/0446/22 O and O the O Slovak B-ORG Research I-ORG and I-ORG Development I-ORG Agency I-ORG under O contract O No. O APVV-16–0446 B-AWARD Moreover O this O publication O is O the O result O of O the O project O implementation O “Open O scientific O community O for O modern O interdisciplinary O research O in O medicine O OPENMED)” O ITMS2014 B-AWARD 313011V455 O supported O by O the O Operational O Programme O Integrated O Infrastructure O funded O by O the O ERDF B-ORG This O research O was O funded O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 91842304 B-AWARD and O 81771761 B-AWARD Health O Research O Fund O from O Yichang O Science O and O Technology O Bureau O A20-2-035 O Hong O Kong O Health B-ORG and I-ORG Medical I-ORG Research I-ORG Fund I-ORG 17160832 O and O Hong O Kong O Croucher B-ORG Foundation I-ORG 260960116 O This O work O was O supported O by O the O Modern O Seed O Industry O Park O for O White O Leg O Shrimp O of O Guangdong O Province O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 32072988 B-AWARD General B-ORG Program I-ORG of I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O China O Grant O No. O 2020A1515010319 B-AWARD and O Guangdong B-ORG Postgraduate I-ORG Education I-ORG Innovation I-ORG Project I-ORG Grant O No. O 202265 B-AWARD This O study O is O partly O supported O by O the O CHOC B-ORG Children’s–UC I-ORG Irvine I-ORG Child I-ORG Health I-ORG Research I-ORG Awards I-ORG 16004004 O the O CHOC-UCI B-ORG Child I-ORG Health I-ORG Research I-ORG grant I-ORG 16004003 O and O the O CHOC B-ORG CSO I-ORG grant I-ORG 16986004 O The O work O was O supported O in O part O by O grants O R01 O CA167516 I-AWARD and O R01CA233201 B-AWARD received O from O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH O to O RR; O an O Institutional O Development O Award O IDeA O from O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG P20 O GM103639 O of O the O National O Institutes O of O Health O RR O a O Merit O Grant O 101BX003420A1 O from O the O Department O of O Veterans O Affairs O RR O a O Pilot O Grant O AS) O and O Seed O Grant O AM) O funded O by O the O National O Cancer O Institute O Cancer O Center O Support O Grant O P30CA225520 O awarded O to O the O University O of O Oklahoma O Stephenson O Cancer O Center O by O the O Department O of O Defense O through O the O Lung O Cancer O Research O Program O LCRP O under O award O no. O W81XWH-18-1-0637 O AS) O O W81XWH-19-1-0647 O RR O a O grant O from O the O Oklahoma B-ORG Center I-ORG for I-ORG the I-ORG Advancement I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG OCAST O HR18-088 B-AWARD to O RR; O and O by O funds O received O from O the O Stephenson O Cancer O Center O Seed O Grant O RR O Presbyterian O Health O Foundation O Seed O Grant O RR, O AM O Presbyterian O Health O Foundation O Bridge O Grant O RR, O AM O and O Jim O and O Christy O Everest O Endowed O Chair O in O Cancer O Developmental O Therapeutics O RR) O at O the O University O of O Oklahoma O Health O Sciences O Center O This O work O was O supported O by O the O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No.7154216 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81503262 B-AWARD and O the O Doctoral B-ORG Foundation I-ORG of I-ORG Baotou I-ORG Medical I-ORG College(No O BSJJ201607 B-AWARD This O work O was O funded O by O National O Funds O through O FCT—Foundation B-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG through O the O project O PTDC/AGR-PRO/0676/2014 B-AWARD as O well O as O by O the O projects O UIDB/05183/2020 B-AWARD UID/MULTI/04046/2019 B-AWARD and O UIDB/04129/2020 B-AWARD of O the O Research B-ORG Units I-ORG MED—Instituto I-ORG Mediterrâneo I-ORG para I-ORG a I-ORG Agricultura I-ORG Ambiente I-ORG e I-ORG Desenvolvimento I-ORG Universidade O de O Évora O BioISI—Biosystems B-ORG and I-ORG Integrative I-ORG Sciences I-ORG Institute I-ORG Faculdade O de O Ciências O Universidade O de O Lisboa O and O LEAF—Linking B-ORG Landscape I-ORG Environment I-ORG Agriculture I-ORG and I-ORG Food I-ORG Research I-ORG Center I-ORG Instituto O Superior O de O Agronomia O This O work O was O supported O by O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG 31402099 O National B-ORG Dairy I-ORG Industry I-ORG and I-ORG Technology I-ORG System I-ORG CARS-37 O and O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG S2016G4513 O The O funding O body O has O not O participated O in O or O interfered O with O the O research O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82171035 O the O National O Natural O Science O Foundation O of O China O 82000946 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2021A1515012238 O the O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG 202201020337 O the O Guangzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 202201020522 O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Projects I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2021B1111610006 O and O the O Key-Area B-ORG Research I-ORG and I-ORG Development I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2020B1111190001 O The O funders O had O no O role O in O the O study O design O data O collection O data O analysis O data O interpretation O or O writing O of O the O report O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 3157010904 B-AWARD and O 31800137 B-AWARD and O the O Postgraduate O Research O O Practice O Innovation O Program O of O Jiangsu O Province O grant O number O KYCX17_1753 O and O Natural B-ORG science I-ORG foundation I-ORG of I-ORG Jiangsu I-ORG Province O grant O number O BK20160507 B-AWARD and O research B-ORG funding I-ORG from I-ORG Jiangsu I-ORG University O grant O number O 17JDG010 B-AWARD This O research O was O funded O by O The B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China O grant O number O 2018YFB0905801 B-AWARD the O basic O scientific O research O project O of O XJTU O xjj2018231 O the O China O Postdoctoral O Science O Foundation O grant O number O 2017M613135 O the O State B-ORG Key I-ORG Lab I-ORG of I-ORG Electrical I-ORG Insulation I-ORG and I-ORG Power I-ORG Equipment O grant O number O EIPE18306 B-AWARD the O Shaanxi B-ORG Postdoctoral I-ORG Science I-ORG Foundation O grant O number O 2017BSHEDZZ28 B-AWARD This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81302184 O 81772951 B-AWARD Jiangsu B-ORG Province’s I-ORG Key I-ORG Discipline I-ORG ZDXKA2016001 O the B-ORG Priority I-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O Funds O for O this O project O were O provided O by O the O Earmarked B-ORG Fund I-ORG for I-ORG Modern I-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG CARS-09-P18 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0200806 O the O Earmarked B-ORG Fund I-ORG for I-ORG Modern I-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG in I-ORG Hebei I-ORG Province I-ORG China I-ORG HBCT2018080205 O the O Study B-ORG on I-ORG Microbial I-ORG Flora I-ORG Structure I-ORG of I-ORG Potato I-ORG Rhizosphere I-ORG Soil I-ORG JY2018002 O and O the O Provincial B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG No.BK20191219 O This O work O was O financial O supported O by O Key B-ORG Research I-ORG and I-ORG Development I-ORG Programs I-ORG of I-ORG Hainan I-ORG Province I-ORG Grant O no. O ZDYF2018224 B-AWARD Chinese B-ORG Modern I-ORG Technology I-ORG System I-ORG of I-ORG Agricultural I-ORG Industry I-ORG Grant O no. O CARS-42-1 B-AWARD and I-AWARD CARS-42-50 O and O Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG for I-ORG Chinese I-ORG Academy I-ORG of I-ORG Tropical I-ORG Agricultural I-ORG Sciences I-ORG Grant O no. O 1630032017034 B-AWARD This O study O was O supported O by O the O PhD I-ORG Start-up I-ORG Funds I-ORG of I-ORG Guangzhou I-ORG Medical I-ORG College I-ORG Guangdong I-ORG Province I-ORG China I-ORG 2014C45 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81502342 O and O the B-ORG Major I-ORG Project I-ORG of I-ORG Guangzhou I-ORG Medical I-ORG College I-ORG Guangdong I-ORG Province I-ORG China I-ORG 2015-yz-02 O This O work O was O supported O by O the O Program B-ORG for I-ORG Changjiang I-ORG Scholars I-ORG and I-ORG Innovative I-ORG Research I-ORG Team I-ORG in I-ORG University I-ORG PCSIRT I-ORG No. O IRT16R35 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 51671098 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Gansu I-ORG Province I-ORG No. O 17JR5RA210 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG lzujbky-2015-122 O This O study O was O funded O by O the O Key B-ORG Project I-ORG of I-ORG Natural I-ORG Science I-ORG Research I-ORG of I-ORG the I-ORG Anhui I-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG KJ2018A0219 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81970313 O and O the O Innovation B-ORG Team I-ORG of I-ORG Cardiovascular I-ORG Injury I-ORG and I-ORG Protection I-ORG Foundation I-ORG and I-ORG Clinical I-ORG Application I-ORG BYKC201906 O The O authors O declare O that O the O funding O body O was O not O involved O in O study O design O data O collection O analysis O interpretation O and O writing O of O the O study O The O research O leading O to O these O results O has O received O funding O from O the O European B-ORG Research I-ORG Council I-ORG under O the O European B-ORG Union’s O Seventh O Framework O Programme O FP7/2007-2013)/ERC O grant O agreement O n° O 616905 O NW O received O funding O from O the O BMBF B-ORG 01EW1711A O O B) O in O the O framework O of O ERA-NET O NEURON O and O from O the O NISCI O project O funded O by O the O European O Union’s O Horizon O 2020 O research O and O innovation O programme O under O the O grant O agreement O No O 681094 B-AWARD and O the O Swiss O State O Secretariat O for O Education O Research O and O Innovation O SERI O under O contract O number O 15.0137 O This O study O was O supported O by O grants O from O the O First B-ORG Hospital I-ORG of I-ORG Jilin I-ORG University I-ORG NO. O JDYYJC006 B-AWARD the O Tianqing B-ORG Liver I-ORG Disease I-ORG Research I-ORG Fund I-ORG NO. O TQGB20180160 B-AWARD and O the O Department B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Jilin I-ORG Province I-ORG NO.20180520116JH O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O has O been O supported O by O the O President’s O Emergency O Plan O for O AIDS O Relief O PEPFAR O through O the O Health B-ORG Resources I-ORG and I-ORG Services I-ORG Administration O under O award O number O U91HA0680 B-AWARD and O the O US O Centers B-ORG for I-ORG Disease I-ORG Control I-ORG and I-ORG Prevention I-ORG https://www.cdc.gov O under O award O number O NU2GGH001130-04-00 B-AWARD to O the O International O Training O and O Education O Center O for O Health O I-TECH O at O the O University O of O Washington O Research O reported O in O this O publication O was O also O supported O by O NIAID O NCI O NIMH O NIDA O NICHD O NHLBI O NIA O NIGMS O NIDDK O of O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG https://www.nih.gov O under O award O number O AI027757 B-AWARD to O the O University O of O Washington O Center O for O AIDS O Research O CFAR O The O findings O and O conclusions O in O this O report O are O those O of O the O authors O and O do O not O necessarily O represent O the O official O position O of O the O Centers O for O Disease O Control O and O Prevention O the O National O Institutes O of O Health O or O the O Health O Resources O and O Services O Administration O This O work O was O supported O by O the O Chinese B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grants I-ORG 81401670 O the O China B-ORG Mega-Project I-ORG for I-ORG Infectious I-ORG Diseases O 2011ZX10004-101 O 2012ZX10004215 B-AWARD and O the B-ORG SKLID I-ORG Development I-ORG Grant I-ORG 2012SKLID102 O This O work O was O supported O by O funding O from O the O Wellcome B-ORG Trust I-ORG grant O number O 220646/Z/20/Z B-AWARD the O European B-ORG Research I-ORG Council I-ORG ERC O under O the O European O Union’s O Horizon O 2020 O research O and O innovation O programme O grant O agreement O No. O 101001684 B-AWARD and O Science B-ORG Foundation I-ORG Ireland I-ORG Grant O number O 12/RC/2273_P2 B-AWARD This O work O was O funded O by O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG Central I-ORG Nonprofit I-ORG Research I-ORG Institutes I-ORG 1610332016010 O the B-ORG Chinese I-ORG National I-ORG Key I-ORG Basic I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2014CB138804 O and O the B-ORG Chinese I-ORG National I-ORG Key I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2012BAD13B07 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O the O manuscript O preparation O This O study O is O supported O by O Seed-Plot B-ORG Foundation I-ORG of I-ORG PLA I-ORG General I-ORG Hospital I-ORG No. O 14KMM36 O Application B-ORG Technology I-ORG Research I-ORG and I-ORG Demonstration I-ORG Projects I-ORG of I-ORG Hainan I-ORG Province I-ORG No. O ZDXM2015089 O and O Medical B-ORG and I-ORG Health I-ORG Technology I-ORG Innovation I-ORG Projects I-ORG of I-ORG Sanya I-ORG No. O 2014YW26 I-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81772413 O 81601941 I-AWARD 81702207 I-AWARD 81702206 I-AWARD 81601941 I-AWARD 81802212 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG 2018YFB1105705 O the O Scientific B-ORG Research I-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Office I-ORG of I-ORG Hunan I-ORG Province I-ORG 2017TP1005 O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Hunan I-ORG Province I-ORG 2018SK2070 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG 2017JJ3491 O 2017JJ3492 I-AWARD 2018JJ3825 O and O the O Postgraduate B-ORG Independent I-ORG Exploration I-ORG and I-ORG Innovation I-ORG Project I-ORG of I-ORG Hunan I-ORG Province I-ORG CX2017B065 O This O work O was O supported O by O grants O from O the O Heilongjiang B-ORG Postdoctoral I-ORG Funding I-ORG LRB O 127555 O Doctoral B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG 201507-41 O National B-ORG Hemp I-ORG Industry I-ORG Technology I-ORG System I-ORG CARS-19 O and O Project B-ORG of I-ORG Harbin I-ORG Innovative I-ORG Talents I-ORG 2013RFQYJ162 O This O project O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31702058 B-AWARD 31672324 B-AWARD 31801994 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Tianjin I-ORG No. O 18JCYBJC96300 B-AWARD 17JCQNJC14900 B-AWARD 14JCQNJC14600 B-AWARD 18JCQNJC14700 B-AWARD and O the O Tianjin B-ORG Normal I-ORG University I-ORG Foundation I-ORG 5RL104 O 043135202-XB1715 B-AWARD 52XB1003 B-AWARD 52XB1005 B-AWARD 043135202-XK1706 B-AWARD 135305JF79 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Cardiovascular B-ORG Multidisciplinary I-ORG Integrated I-ORG Research I-ORG Fund I-ORG CIMF-Z-2016-23-1823 O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR201702210404 O the O Clinical B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG of I-ORG Jinan I-ORG City I-ORG 201805040 O and O the O Medicine B-ORG and I-ORG Health I-ORG Science I-ORG Technology I-ORG Development I-ORG of I-ORG Shandong I-ORG Province I-ORG 2017WS191 O This O research O was O funded O by O the B-ORG National I-ORG Key I-ORG Project I-ORG of I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG Grant O No. O 2017YFD0201103 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31722046 B-AWARD the O Fund B-ORG of I-ORG Fok I-ORG Ying I-ORG Tung I-ORG Education I-ORG Foundation I-ORG Grant O No. O 151031 B-AWARD and O the O earmarked O fund O for O China O Agriculture O Research O System O Grant O No. O CARS-13 B-AWARD The O research O was O supported O by O the O Strategic O Priority O Research O Program O B) O of O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG grants O XDB B-AWARD 26000000 I-AWARD and O 18000000 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O grants O 41672001 B-AWARD 41272002 B-AWARD and O 41688103 B-AWARD the O Key O research O program O of O Frontier B-ORG Sciences I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG grant O QYZDB-SSW-DQC040 B-AWARD and O the O Funds O for O Paleontology O Fieldwork O and O Fossil O Preparation O Chinese O Academy O of O Sciences O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81700127 B-AWARD No. O 81602735 B-AWARD No. O 81701962 B-AWARD No. O 81801967 B-AWARD Project B-ORG of I-ORG Hunan I-ORG health I-ORG and O No.C2016066 O Natural B-ORG science I-ORG foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG No.2018JJ32589 O This O study O was O partly O funded O by O the O Spanish B-ORG ‘Ministerio I-ORG de I-ORG Economía I-ORG y I-ORG Competitividad’ I-ORG and I-ORG FEDER I-ORG project O CGL2012-36181 B-AWARD to O XC) O and O the O ‘Ministerio O de I-ORG Ciencia I-ORG e I-ORG Innovación’ O project O Consolider O MONTES O CSD O 2008-00040 B-AWARD to O JR O XA O was O supported O by O the O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG of I-ORG Brazil I-ORG CNPq O PDS-167533/2013-4 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O a O special O clinical O medicine O research O funds O from O the O Chinese B-ORG Medical I-ORG Association I-ORG 14050370574 O XL O grant O from O medical O scientific O research O projects O of O Chongqing B-ORG Municipal I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG 20142031 O XL O Natural B-ORG Science I-ORG Foundation I-ORG Project I-ORG of I-ORG CQ I-ORG CSTC(cstc2015jcyjA10069 O and O the O found O for O fostering O talents O in O scientific O research O of O Chongqing B-ORG Medical I-ORG University I-ORG 201404 O XL O the O same O as O Funding O Information O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O “Overseas O study I-ORG visit I-ORG and I-ORG training I-ORG program I-ORG for I-ORG outstanding I-ORG young I-ORG backbone I-ORG talents I-ORG of I-ORG Anhui I-ORG Province O grant O number O gxgwfx2021035” B-AWARD “Innovation O team O of O Anhui O Polytechnic O University” O “Special O display I-ORG and I-ORG Imaging I-ORG Technology I-ORG Anhui I-ORG Technology I-ORG Innovation I-ORG Center I-ORG open I-ORG project O grant O number O 2020AJ06001” B-AWARD “Anhui O Polytechnic I-ORG University-Jiujiang I-ORG District I-ORG Industrial I-ORG Collaborative I-ORG Innovation I-ORG Special I-ORG Fund I-ORG Project O grant O number O 2022cyxtb4 B-AWARD 2022cyxtb6 B-AWARD and O 2022cyxtb8” B-AWARD “Anhui O Provincial I-ORG Natural I-ORG Science I-ORG Foundation O grant O number O 1908085QA13” B-AWARD “National O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 11902001” B-AWARD ” O Natural B-ORG Science I-ORG Research I-ORG Project I-ORG of I-ORG Institutions I-ORG of I-ORG Higher I-ORG Education I-ORG in I-ORG Anhui I-ORG Province O grant O number O KJ2017A114” B-AWARD This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81874017 O the O Cuiying B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG Lanzhou I-ORG University I-ORG Second I-ORG Hospital I-ORG CY2017-ZD02 O CY2017-QN12 B-AWARD the O Research B-ORG Project I-ORG of I-ORG Gansu I-ORG Province I-ORG Chinese I-ORG Medicine I-ORG Administration I-ORG GZK-2017-51 O The O funding O body O made O no O other O contributions O to O any O aspects O of O this O study O This O work O was O supported O by O the O National B-ORG Institute I-ORG of I-ORG Environmental I-ORG Health I-ORG Sciences I-ORG grant O numbers O R21ES020984 B-AWARD American B-ORG Heart I-ORG Association I-ORG grant O number O 12GRNT12070254 B-AWARD and O the O Robert B-ORG H. I-ORG Lurie I-ORG Comprehensive I-ORG Cancer I-ORG Center I-ORG O Rosenberg B-AWARD Family I-AWARD Cancer I-AWARD Research I-AWARD Fund O MSG O was O financially O supported O by O the O Fundación B-AWARD México I-AWARD en I-AWARD Harvard O A.C B-ORG and I-ORG Consejo I-ORG Nacional I-ORG de I-ORG Ciencia I-ORG y I-ORG Tecnología I-ORG CONACYT-Mexico O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O In O Australia O this O work O was O supported O by O grants O from O the O Australian O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG NHMRC I-ORG 1068409 O and O 1107094 B-AWARD to O D.R.T O the O Australian B-ORG Mitochondrial I-ORG Disease I-ORG Foundation O an O NHMRC O Principal O Research O Fellowship O 1102896 O to O D.R.T O an O NHMRC B-ORG Early I-ORG Career I-ORG Fellowship I-ORG 1054432 O to O E.J.T O an O NHMRC O scholarship O H.S.M O an O Australian O Postgraduate O Award O N.J.L O and O the O Victorian O Government’s O Operational O Infrastructure O Support O Program O In O the O UK, O the O study O was O funded O by O the O Medical O Research O Council O intramural O award O to O I.J.H O to O April O 2016 O and O a O senior O non-clinical O fellowship O to O A.S O MC_PC_13029 O In O France O the O work O was O supported O by O grants O from O the O FRM O Fondation O pour I-ORG la I-ORG Recherche I-ORG Médicale O grant O DPM20121125550 B-AWARD to O A.L O from O the O Association O Française O contre O les O Myopathies O AFM O to O A.L O and O Association O contre O les O Maladies O Mitochondriales O AMMi O to O A.L O In O the O Netherlands O the O work O was O supported O by O a O CSBB B-ORG grant O 853.00.130 O from O NWO-ALW O to O J.S O In O Japan O the O work O was O supported O by O a O Strategic O Research O Center O in O Private O Universities O grant O from O the O Ministry O of O Education O Culture O Sports O Science O and O Technology O MEXT O and O by O the O Practical O Research O Project O for O Rare/Intractable O Diseases O from O the O Japan O Agency O for O Medical O Research O and O Development O AMED O This O work O was O supported O by O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2013CB910102 O a O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31222036 B-AWARD 31471303 O a O Project O Funded O by O the O Priority O Academic O Program O Development O of O Jiangsu O Higher O Education O Institutions O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grant I-ORG BK2012004 O and O the O Undergraduate O Training O Programs O for O Innovation O and O Entrepreneurship O This O study O was O supported O by O the O Center B-ORG for I-ORG Advanced I-ORG Surface I-ORG Engineering O under O the O United O States O National O Science O Foundation O Grant O No. O IIA-1457888 B-AWARD and O the O Arkansas O EPSCoR O Program O ASSET O III O Arkansas O Biosciences O Institute O Jonesboro O AR O provided O facility O support O for O rNSC O differentiation O experiments O Undergraduate O student O support O was O provided O by O the O Cell O Biology O Education O Consortium O an O NSF-RCN-UBE B-ORG Grant O No. O 1827066 B-AWARD and O the O J.D O Patterson O Research O Experience O for O Undergraduates O at O Ouachita O Baptist O University O The O AR-INBRE B-ORG program I-ORG NIGMS O P20 B-AWARD GM103429 I-AWARD provided O support O for O RNA O sequencing O This O work O was O partially O sponsored O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O BK20161460 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81503316 B-AWARD College B-ORG Students I-ORG Innovation I-ORG Project I-ORG for I-ORG the I-ORG R&D I-ORG of I-ORG Novel I-ORG Drugs I-ORG No. O J1030830 B-AWARD the O Priority O Academic O Program O Development O of O Jiangsu O Higher O Educational O Institutions O and O the O development O program O for O the O Young O and O Middle-Aged O Teachers O of O Common O Colleges O and O Universities O of O JiangXi O Funding O was O provided O by O the O Natural B-ORG Sciences I-ORG and I-ORG Engineering I-ORG Research I-ORG Council I-ORG #1025 O of O Canada O Federal B-ORG Program I-ORG Office I-ORG of I-ORG International I-ORG Polar I-ORG Year I-ORG MD-112 O Nunavut B-ORG Wildlife I-ORG Management I-ORG Board I-ORG #3-09-04 O ArcticNet B-ORG #317588 O and O Fisheries B-ORG and I-ORG Oceans I-ORG Canada I-ORG NIF-05 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O authors O would O like O to O thank O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 81373262 B-AWARD 81773579 B-AWARD the O Science B-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG no. O LY16B020010 B-AWARD LY17B020008 B-AWARD the O Opening B-ORG Project I-ORG of I-ORG Zhejiang I-ORG Provincial I-ORG Top I-ORG Key I-ORG Discipline I-ORG of I-ORG Pharmaceutical I-ORG Sciences I-ORG no. O 201710 B-AWARD 201715 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Wenzhou I-ORG no. O Y20150110 B-AWARD for O their O financial O support O This O study O has O received O funding O by O Traditional B-ORG Chinese I-ORG Medicine I-ORG Scientific I-ORG Research I-ORG Funds I-ORG of I-ORG Zhejiang I-ORG province I-ORG No.2018ZA057 O Medicine B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. O 2017KY123 O Public B-ORG Projects I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No.2016C37092 O Comparative B-ORG Medical I-ORG Innovation I-ORG Team I-ORG of I-ORG Zhejiang I-ORG Chinese I-ORG Medical I-ORG University I-ORG No.XTD201301 O and O Research B-ORG Fund I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Chinese I-ORG Medical I-ORG University I-ORG No. O 2017ZZ01 O China O This O work O was O supported O by O the O European B-ORG Research I-ORG Council I-ORG under O the O Grant O Agreement O ERC-StG O 638284 O by O Ministerio B-ORG de I-ORG Ciencia I-ORG e I-ORG Innovación I-ORG Spain O through O Project O PID2019-105674RB-I00 B-AWARD and O by O European B-ORG Social I-ORG Fund I-ORG EU) O and O Aragón O Government O through O BSICoS O group O T39\_20R O and O Project O LMP124-18 B-AWARD Computations O were O performed O by O the O ICTS O NANBIOSIS O HPC O Unit O at O University O of O Zaragoza O L. O García-Mendívil O was O supported O by O a O fellowship O from O Diputación B-ORG General I-ORG de I-ORG Aragón I-ORG C150/2016 O This O study O is O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81774451 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017A030313827 O Science O and O Technology O program O of O Guangdong O Province O 2014B090902002 O Science O Program O for O Overseas O Scholar O Xinhuo O plan O of O Guangzhou O University O of O Chinese O Medicine O and O the O Outstanding B-ORG Youth I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG Colleges I-ORG and I-ORG Universities I-ORG YQ2015041 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 61805107 O 61705085 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017A030313006 O and O the O Innovation B-ORG and I-ORG Entrepreneurship I-ORG Team I-ORG Project I-ORG 2016ZT06D081 O Funding O was O provided O by O Industrial B-ORG Strategic I-ORG Technology I-ORG Development I-ORG Program I-ORG Grant O No. O 10052668 B-AWARD Technology B-ORG Innovation I-ORG Program I-ORG Grant O No. O 10065730 B-AWARD Korea B-ORG Institute I-ORG of I-ORG Energy I-ORG Technology I-ORG Evaluation I-ORG and I-ORG Planning I-ORG Grant O No. O 20154030200870 B-AWARD This O research O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFB1200702 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Project O No. I-AWARD 61703351 I-AWARD 71971182 O Science B-ORG and I-ORG Technology I-ORG Plan I-ORG of I-ORG China I-ORG Railway I-ORG Corporation I-ORG Project O No. I-AWARD P2018T001 I-AWARD P2018X001 I-AWARD N2018X006-01 O and O the B-ORG Sichuan I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG Project O NO. I-AWARD 2020YFH0035 O 2020YJ0268 B-AWARD 2020YJ025 B-AWARD 2020JDRC0032 B-AWARD This O research O was O funded O by O the O Science O Challenge O Project O No.TZ2016001 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 51372188 B-AWARD 51521001 I-AWARD 51861145306 I-AWARD and I-AWARD 51872212 O and O by O the O 111 O Project O B13035 O This O research O was O also O funded O by O the O International O Science O and O Technology O Cooperation O Program O of O China O 2014DFA53090 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province O China O 2016CFA006 O the O Fundamental O Research O Funds O for O the O Central O Universities O WUT O 2017YB004 O 2018III016 O and O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Advanced I-ORG Technology I-ORG for I-ORG Materials I-ORG Synthesis I-ORG and I-ORG Processing I-ORG WUT O Grant I-AWARD No. I-AWARD 2019-KF-12 O This O work O was O supported O in O part O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no O 81671568 B-AWARD Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG grant O no O 2016A020215106 B-AWARD and O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangzhou I-ORG grant O no O 201607010195 B-AWARD The O work O of O A.M.B O C.C.M O J.D.S O and O L.M.A O were O supported O in O part O by O the O National B-ORG Cancer I-ORG Institute I-ORG of I-ORG the I-ORG National I-ORG Institutes I-ORG of I-ORG Health I-ORG under O Award O Number O U54CA217376 B-AWARD C.C.M O was O also O supported O in O part O by O National O Institutes O of O Health O grants O U2C B-AWARD CA233254 O P01 B-AWARD CA91955 O R01 B-AWARD CA170595 O R01 B-AWARD CA185138 I-AWARD and O R01 B-AWARD CA140657 I-AWARD as O well O as O CDMRP O Breast O Cancer O Research O Program O Award O BC132057 B-AWARD and O the O Arizona B-ORG Biomedical I-ORG Research I-ORG Commission I-ORG grant I-ORG ADHS18-198847 B-AWARD The O research O presented O in O this O paper O has O been O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG O Development B-ORG Program I-ORG of I-ORG China I-ORG no. O 2018YFC0807900 B-AWARD and O 2018YFC0807903 B-AWARD National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG under I-ORG Grant I-ORG No. O 61702020 B-AWARD and O Beijing O Nature O Science O Foundation O Grant O No. O 4172013 B-AWARD Funded O by O the O Graduate O Research O Capacity O Improvement O Program O of O Beijing O Technology O and O Business O University O in O 2019 O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 71473057 B-AWARD the O China B-ORG Association I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG High-End I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Think I-ORG Tank I-ORG Youth I-ORG Project I-ORG grant O number O 2021ZZZLFZB1207070 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG grant O number O HIT.HSS.ESD202306 B-AWARD This O work O was O jointly O supported O by O Wu B-ORG Jieping I-ORG Medical I-ORG Foundation I-ORG 320.2710.1857 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81874182 O 81874056 B-AWARD National B-ORG Key I-ORG Project I-ORG of I-ORG China I-ORG 2017ZX10203204-007-004 O This O work O was O supported O by O grants O from O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG 2017R1A2B2012190 O the O National B-ORG Research I-ORG Council I-ORG of I-ORG Science I-ORG I-ORG Technology I-ORG CRC-15-02-KRIBB O and O the O Ministry B-ORG of I-ORG Food I-ORG and I-ORG Drug I-ORG Safety I-ORG 18172BIO182 O This O work O is O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG in I-ORG China I-ORG 31671742 O the O National B-ORG Project I-ORG of I-ORG Modern I-ORG Agricultural I-ORG Industry I-ORG Technology I-ORG System I-ORG in I-ORG China I-ORG CARS-15-05 O the O Taishan B-ORG Scholars I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG ts201511070 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O Special O Fund O for O Anhui B-ORG Agriculture I-ORG Research I-ORG System I-ORG AHCYYJSTX-04 O the O Joint B-ORG Research I-ORG Project I-ORG on I-ORG the I-ORG Anhui I-ORG Local I-ORG Pigs I-ORG Breeding I-ORG and I-ORG Utilization I-ORG 340000211260001000431 O the O Open B-ORG Fund I-ORG of I-ORG Anhui I-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Embryo I-ORG Development I-ORG and I-ORG Reproduction I-ORG Regulation I-ORG FSKFKT004 O Innovation B-ORG and I-ORG Entrepreneurship I-ORG Training I-ORG Plan I-ORG of I-ORG Anhui I-ORG Agricultural I-ORG University I-ORG for I-ORG Undergraduate I-ORG Student I-ORG 202110364055 O and O Major B-ORG special I-ORG science I-ORG and I-ORG technology I-ORG project I-ORG of I-ORG Anhui I-ORG Province I-ORG 202103a06020013 O This O work O was O supported O in O part O by O the O US O National B-ORG Institutes I-ORG of I-ORG Health/National O Cancer I-ORG Institute I-ORG NIH/NCI O R01 B-AWARD CA69316-01A1 I-AWARD and O P50 B-AWARD CA097257 I-AWARD to O J.F.C O a O generous O gift O from O the O Dabbiere O Family O to O J.F.C O NIH/NCI O T32 O grant O 2T32CA151022 B-AWARD to O L.E.J O and O M.R.G O NIH/NCI O F32 O grant O 5F32CA206252 B-AWARD to O M.R.G O University B-ORG of I-ORG California O San O Francisco O UCSF O CTSI O TL1 O grant O TR001871 B-AWARD to O S.H O NIH O grant O 1F32CA225054-01 B-AWARD to O S.H O and O NIH O grant O 5T32CA151022-07 B-AWARD to O S.H O Research O reported O in O this O article O was O funded O through O a O Patient-Centered B-ORG Outcomes I-ORG Research I-ORG Institute I-ORG PCORI O Award O CE-1304-6301 O and O the O Pittsburgh B-ORG Older I-ORG Americans I-ORG Independence I-ORG Center I-ORG NIA O P30 I-AWARD AG024827 O The O statements O in O this O article O are O solely O the O responsibility O of O the O authors O and O do O not O necessarily O represent O the O views O of O the O Patient-Centered O Outcomes O Research O Institute O PCORI O its O Board O of O Governors O or O Methodology O Committee O In O addition O JS O Brach O was O supported O by O a O Midcareer B-ORG Investigator I-ORG Award I-ORG in I-ORG Patient I-ORG Oriented I-ORG Research I-ORG K24 O AG057728 O The O funding O bodies O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O funded O by: O National B-ORG Science I-ORG Fund I-ORG for I-ORG Excellent I-ORG Young I-ORG Scholars I-ORG 51322811 O Science B-ORG and I-ORG Technology I-ORG Development I-ORG Planning I-ORG of I-ORG Shandong I-ORG Province I-ORG 2012GGE27027 O Program B-ORG for I-ORG New I-ORG Century I-ORG Excellent I-ORG Talents I-ORG in I-ORG University I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG NCET-12-0341 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 52005115 B-AWARD the O Guangxi B-ORG Hundred I-ORG Talent I-ORG Program I-ORG grant O number O T3010097923 B-AWARD and O the O Guangxi B-ORG Ba I-ORG Gui I-ORG Scholar I-ORG Program I-ORG grant O number O 2019A02 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Fund I-ORG No. O 81972285 B-AWARD the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Chongqing I-ORG Chongqing O China O CSTB2022NSCQ-MSX1038 B-AWARD CSTB2022NSCQ-MSX0775 B-AWARD Senior B-ORG Medical I-ORG Talents I-ORG Program I-ORG of I-ORG Chongqing I-ORG for I-ORG Young I-ORG and I-ORG Middle-aged I-ORG and I-ORG Kuanren I-ORG Talents I-ORG Program I-ORG of I-ORG the I-ORG Second I-ORG Affiliated I-ORG Hospital I-ORG of I-ORG Chongqing I-ORG Medical I-ORG University I-ORG 13-002-011 O 13-004-009 B-AWARD Hetao B-ORG Shenzhen-Hong I-ORG Kong I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Cooperation I-ORG Zone I-ORG Shenzhen I-ORG Park I-ORG Project I-ORG HZQB-KCZYZ-2021017 O P.V.C O thanks O EPSRC B-ORG for I-ORG its I-ORG support I-ORG via I-ORG the I-ORG 2020 I-ORG Science I-ORG Programme I-ORG EP/I017909/1 O the O Qatar B-ORG National I-ORG Research I-ORG Fund I-ORG 7-1083-1-191 O MRC B-ORG for I-ORG a I-ORG Medical I-ORG Bioinformatics I-ORG grant O MR/L016311/1 O and O the O UCL O Provost O for O a O Strategic O Award O E.R.D O acknowledges O the O Los O Alamos O National O Laboratory O for O funding O in O Statistical O Modeling O for O Information-Driven O Materials O Discovery O and O Design O The O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 71603188 B-AWARD and O 71603292 B-AWARD the O Humanity B-ORG and I-ORG Social I-ORG Science I-ORG Youth I-ORG Foundation I-ORG from I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG grant O numbers O 16YJCZH137 B-AWARD the O National B-ORG Social I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 16GBL150 B-AWARD This O work O was O supported O by O grants O from O Beijing B-ORG Municipal I-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 7152054 B-AWARD Study O on O the O mechanism O of O relapse O resulting O from O low O expression O of O CASP8AP2 O in O acute O B O lymphoblastic O leukemia O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81170504 B-AWARD 81200392 B-AWARD Beijing B-ORG Health I-ORG Qualified I-ORG Personnel I-ORG Program I-ORG No. O 2011-3-049 B-AWARD Scientific O Research O Common O Program O of O Beijing O Municipal O Commission O of O Education O KM201810025025 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81572898 B-AWARD 81673475 B-AWARD 81502996 B-AWARD 81601370 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG and I-ORG Liaoning I-ORG joint I-ORG fund I-ORG key I-ORG program I-ORG No. O U1608281 B-AWARD The B-ORG Drug I-ORG Innovation I-ORG Major I-ORG Project I-ORG Grant O no O 2018ZX09711001-008-006 B-AWARD Key B-ORG Laboratory I-ORG Foundation I-ORG from I-ORG Shenyang I-ORG S&T I-ORG Projects I-ORG Z18-4-020 O Liaoning B-ORG Province I-ORG Scientific I-ORG Research I-ORG Foundation I-ORG 20180550500 O and O Liaoning O Province O Scientific O Research O Foundation O LQNK20173 O 20170541024 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundations I-ORG of I-ORG China I-ORG 81971135 O Natural B-ORG Science I-ORG Foundations I-ORG of I-ORG Heilongjiang I-ORG YQ2020H014 O “Chunhui B-ORG Plan” I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG HLJ2019009 O Distinguished B-ORG Young I-ORG Foundations I-ORG of I-ORG the I-ORG First I-ORG Affiliated I-ORG Hospital I-ORG of I-ORG Harbin I-ORG Medical I-ORG University I-ORG HYD2020JQ0014 O This O work O was O supported O by O a O National B-ORG Geographic I-ORG Society I-ORG grant O 8002-06 B-AWARD to O R.C O a O Natural B-ORG Environment I-ORG Research I-ORG Council I-ORG research O grant O NE/M00256X B-AWARD to O C.B O The O symposium O was O supported O by O National B-ORG Science I-ORG Foundation I-ORG grant O O IOS-1637160 B-AWARD Company B-ORG of I-ORG Biologists I-ORG grant O EA1233 B-AWARD both O Simon O Lailvaux O and O Jerry O Husak O and O bySociety O for O Integrative O and O Comparative O Biology O divisions O DAB O DCB O DEC O DEDE O DEE O DNB O and O DVM O This O research O was O supported O by O ICN09_015/ACE210007 B-AWARD ANID O Millennium I-ORG grants O BMBF180051 B-AWARD ANID O International I-ORG Collaboration I-ORG Grant O ANID B-ORG FONDECYT I-ORG Grants O 1140545 B-AWARD 11140580 B-AWARD 1170058 B-AWARD and O 1190958 B-AWARD CONICYT B-ORG PhD-scholarships O 21200346 B-AWARD and O 21161086 B-AWARD and O FONDEQUIP-EQM B-ORG Equipment O Grants O ANID B-AWARD 140156 I-AWARD and O 140156 O This O work O was O supported O by O National B-ORG Sciences I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O Grant O Nos O 31370383 B-AWARD and O 31270085 B-AWARD the B-ORG Major I-ORG State I-ORG Basic I-ORG Research I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 973 I-ORG Project I-ORG Grant O No. O 2011CB200904 B-AWARD and O National B-ORG Hi-tech I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 863 I-ORG Project I-ORG Grant O No. O 2013AA065802 B-AWARD The O funding O bodies O did O not O participate O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 22106136 O 42007390 B-AWARD 22006131 B-AWARD 21906117 B-AWARD the O Basic B-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2023A1515012650 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Public I-ORG Welfare I-ORG Research I-ORG Institutes I-ORG No. O PM-zx703-202204-113 B-AWARD and O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O 2020M681864 B-AWARD This O work O was O supported O by O the O Ministry B-ORG of I-ORG Agriculture I-ORG of I-ORG China I-ORG through I-ORG the I-ORG Earmarked I-ORG Fund I-ORG for I-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-023 O by O the O Chinese B-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG through I-ORG the I-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG CAAS-ASTIP-2014-TRICAAS O and O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 31400581 O 31500568 B-AWARD and O 31600562 B-AWARD This O work O was O supported O by O a O joint O research O grant O of O the O Belarusian B-ORG Republican I-ORG Foundation I-ORG for I-ORG Fundamental I-ORG Research I-ORG B20R-061 O and O the O Russian B-ORG Foundation I-ORG for I-ORG Basic I-ORG Research I-ORG 20-54-00005 O V.B O is O supported O by O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Higher I-ORG Education I-ORG of I-ORG the I-ORG Russian I-ORG Federation I-ORG agreement O I-AWARD 075-00337-20-03 I-AWARD project I-AWARD FSMG I-AWARD 2020-0003 O This O work O is O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 51606036 B-AWARD to O HZ O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG no. O QC2014C047 B-AWARD to O HZ) O and O Heilongjiang B-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG Project I-ORG no. O 12541093 B-AWARD to O HZ O Publishing O fee O and O material O fee O including O chemical O reagents O and O personal O protective O equipment O are O supported O by O no. O 51606036 O Experimental O system O renovation O fee O is O supported O by O Natural O Science O Foundation O of O Heilongjiang O Province O no. O QC2014C047 O and O Heilongjiang O Provincial O Department O of O Education O Project O no. O 12541093 O National O Natural O Science O Foundation O of O China O is O sponsored O by O National O Natural O Science O Foundation O of O China,http://www.nsfc.gov.cn O Natural O Science O Foundation O of O Heilongjiang O Province O is O sponsored O by O Science O and O Technology O Department O of O Heilongjiang O Province,http://www.hljkjt.gov.cn O Heilongjiang O Provincial O Department O of O Education O Project O is O sponsored O by O Education O Department O of O Heilongjiang O Province,https://www.hljedu.gov.cn O This O research O was O funded O by O American B-ORG Diabetes I-ORG Association I-ORG 1-16-ICTS-029 B-AWARD by O NIDDK B-AWARD UC4 I-AWARD DK104207 O NIH B-AWARD P30 I-AWARD DK26687-36 O R01 B-AWARD DK I-AWARD 057846-16 I-AWARD to O Kevan O Herold O by O NIH B-AWARD P30 I-AWARD DK0636-08 I-AWARD funding O to O the O Columbia O University O flow O core O the O Weezie O family O foundation O to O D.E O and O by O a O Columbia B-ORG University I-ORG Diabetes I-ORG Research I-ORG Center I-ORG Pilot I-ORG and I-ORG Feasibility I-ORG award O to O L.S O G.A.R O was O supported O by O a O Wellcome B-ORG Trust I-ORG Investigator I-ORG Award I-ORG WT212625/Z/18/Z O an O MRC O Programme O grant O MR/R022259/1 O a O start-up O grant O from O the O Université B-ORG de I-ORG Montréal I-ORG and I-ORG a I-ORG John I-ORG R. I-ORG Evans I-ORG Leaders I-ORG Award I-ORG from I-ORG Innovation I-ORG Canada I-ORG This O study O was O partially O supported O by O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG National I-ORG Institutes I-ORG of I-ORG Health I-ORG grant O GM-076695-02 B-AWARD the O Department B-ORG of I-ORG Defense I-ORG grant O T5-0004271 B-AWARD and O a O Merit O Review O Award O no. O 1 B-AWARD I01 I-AWARD BX005709-01 I-AWARD from O the O Biomedical B-ORG Laboratory I-ORG Research I-ORG I-ORG Development I-ORG Service I-ORG the I-ORG United I-ORG States I-ORG Department I-ORG of I-ORG Veteran I-ORG Affairs O The O content O of O this O publication O does O not O represent O the O views O of O the O U.S O Department O of O Veterans O Affairs O of O the O United O States O Government O This O work O was O funded O by O the O Grains B-ORG Research I-ORG and I-ORG Development I-ORG Corporation I-ORG UWA00150;www.grdc.com.au O the O Australian B-ORG Research I-ORG Council I-ORG Future O Fellowship O Scheme O FT110100246;www.arc.gov.au O awarded O to O D.V.M O The O University O of O Western O Australia O and O a O China B-ORG Scholarship I-ORG Council I-ORG 2011325039 O award O to O P.S O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O National B-ORG Cancer I-ORG Institute I-ORG NCI O award O number O CA198963 B-AWARD and O CA096297/CA096300 B-AWARD National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG award O number O R25GM061838 B-AWARD and O National B-ORG Institute I-ORG on I-ORG Minority I-ORG Health I-ORG and I-ORG Health I-ORG Disparities I-ORG NIMHD O and O the O National O Institute O of O Allergy O and O Infectious O Diseases O NIAID O award O number O MD007587 B-AWARD Additional O support O was O provided O by O NIMHD O award O Number O G12 O MD007600 B-AWARD and O National B-ORG Center I-ORG for I-ORG Research I-ORG Resources I-ORG NCRR O award O number O G12RR03051 B-AWARD Study O data O were O managed O using O REDCap O electronic O data O capture O tools O hosted O at O the O Puerto O Rico O Clinical O and O Translational O Research O Consortium O at O the O University O of O Puerto O Rico O Medical O Sciences O Campus O This O research O was O supported O by O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF I-ORG funded I-ORG by I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG MOE O through O the O “Regional O Innovation O Strategy O RIS)” O 2021RIS-004 O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF I-ORG funded I-ORG by I-ORG the I-ORG Korea I-ORG Government I-ORG MSIT O 2018R1D1A1B07040446 O and O the O Korea B-ORG Institute I-ORG for I-ORG the I-ORG Advancement I-ORG of I-ORG Technology I-ORG KIAT I-ORG funded I-ORG by I-ORG the I-ORG Korea I-ORG Government I-ORG MOTIE O through O the O “Competency O Development O Program O for O Industry O Specialist” O P0008458 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31972147 B-AWARD and O 32272416 B-AWARD Project B-ORG of I-ORG Tianjin I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG No. O 22ZYJDSS00030 B-AWARD and O Project B-ORG Program I-ORG of I-ORG Key I-ORG Laboratory I-ORG of I-ORG Tianjin I-ORG Key I-ORG Laboratory I-ORG of I-ORG Food I-ORG Quality I-ORG and I-ORG Health I-ORG China I-ORG No. O TJS202205 B-AWARD This O work O was O supported O by O the O European B-ORG Commission I-ORG PSYSCAN—Translating O neuroimaging O findings O from O research O into O clinical O practice O 603196 B-AWARD to O P.M O International O Cooperation O and O Exchange O of O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81220108013 O to O Q.G O and O A.M O Wellcome B-ORG Trust’s I-ORG Innovator I-ORG Award I-ORG 208519/Z/17/Z O to O A.M O Foundation B-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG SFRH/BD/103907/2014 O to O S.V O and O São B-ORG Paulo I-ORG Research I-ORG Foundation I-ORG FAPESP O Brazil O 2013/05168-7 B-AWARD to O W.H.L.P O The O authors O have O declared O that O there O are O no O conflicts O of O interest O in O relation O to O the O subject O of O this O study O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 52277147 B-AWARD and O 52007065 B-AWARD the O Beijing B-ORG Natural I-ORG Science I-ORG Foundation O grant O number O 3222057 B-AWARD and O the O Hebei B-ORG Province I-ORG Master’s I-ORG Degree I-ORG Students I-ORG in I-ORG the I-ORG Innovative I-ORG Ability I-ORG Training I-ORG Funding I-ORG Program O grant O number O CXZZSS2022158 B-AWARD This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFE0202900 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2452019078 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41601236 O and O 41761144060 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Science O and O technology O Strategic O cooperation O Project O of O Southwest O Medical O University O of O Luzhou O People’s O Government O No. O 2019LZXNYDJ08 O 2019LZXNYDJ19 O and O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 82003262 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2019TQ0221 B-AWARD 2019M663517 O and O Post-Doctor O Research O Project O West B-ORG China I-ORG Hospital I-ORG Sichuan I-ORG University I-ORG No. O 2019HXBH059 B-AWARD No. O 2020HXBH052 O This O work O was O supported O by O the O Japan B-ORG Agency I-ORG for I-ORG Medical I-ORG Research I-ORG and I-ORG Development I-ORG under O grant O numbers O JP22fk0210111 B-AWARD to O N.N O J.O O N.T O M.S O M.N O A.F O H.Y O T.Y O K.H O N.S O and O K.T O JP22fk0210078 B-AWARD to O N.N O J.O O and O Y.K O JP21fk0210056 B-AWARD to O N.N O J.O O M.S O M.N O A.F O M.M O N.I O N.S O and O K.T O JP22fk0310515 B-AWARD to O M.S O and O M.M O JP22fk0210072 B-AWARD to O G.S O M.S O and O N.S O this O study O was O partly O supported O by O AMED O under O Grant O Number O JP20km0405211 B-AWARD to O J.O O this O work O was O also O supported O by O grants O from O the O National B-ORG Center I-ORG for I-ORG Global I-ORG Health I-ORG and I-ORG Medicine I-ORG 22A1005 O to O N.N O and O J.O O 19A1017 O to O N.N O and O Y.K O this O work O also O was O partially O supported O by O “Joint O Usage/Research I-ORG Center I-ORG for I-ORG Interdisciplinary I-ORG Large-scale I-ORG In-formation I-ORG Infrastructures” O and O “High O Performance I-ORG Computing I-ORG Infrastructure” O in O Japan O Project O ID: O jh210018-NWH B-AWARD and O jh220014 B-AWARD to O M.N O Coordination O for O the O Improvement O of O Higher O Education O Personnel O CAPES O provided O a O scholarship O to O Roseli O Maria O Foratto O The B-ORG São I-ORG Paulo I-ORG Research I-ORG Foundation I-ORG FAPESP I-ORG provided O financial O support O to O Lucas O Rodriguez O Forti O #2013/21519–4 O and O Luís B-ORG Felipe I-ORG Toledo I-ORG #2014/23388-7 O 2016/25358-3 B-AWARD The B-ORG National I-ORG Council I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Development I-ORG CNPq I-ORG provided O a O fellowship O to O Luís O Felipe O Toledo O #300896/2016-6 O and O to O Lucas O Rodriguez O Forti O #438675/2016-9 O Partial O call O analyses O and O call O deposit O were O funded O by O project O TATANKA O CGL2011-25062 O Ministerio O de O Ciencia O e O Innovación O PI, O RM. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O project O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 81572045 B-AWARD the O Capital B-ORG Health I-ORG Research I-ORG and I-ORG Development I-ORG of I-ORG Special I-ORG grant O no. O 2016-2-5062 B-AWARD the O Capital B-ORG Characteristic I-ORG Clinic I-ORG Project I-ORG of I-ORG Beijing I-ORG grant O no. O Z161100000516181 B-AWARD and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0903800 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O authors O thankGrand O Challenges I-ORG Canada(Grant O 0072-03),Bill B-AWARD and I-ORG Melinda I-ORG Gates I-ORG Foundation(Global O Health O Grant O OPP1032713 B-AWARD and O theEunice O Shriver I-ORG Kennedy I-ORG National I-ORG Institute I-ORG of I-ORG Child I-ORG Health I-ORG and I-ORG Development(Grant O R01 B-AWARD HD070993 O for O Financial O Support O The O funders O have O no O involvement O in O the O analysis O and O interpretation O of O the O data O writing O of O the O paper O or O the O decision O to O submit O the O paper O for O publication O MRCMR/P00878X B-ORG to O Sanjay O G O Manohar,Wellcome O Principal I-ORG Fellowship(WT O 098282 B-AWARD to O Masud O Husan,Wellcome O Clinical I-ORG Research I-ORG Training I-ORG Fellowship(WT O 104364/Z/14/Z B-AWARD to O Kinan O Muhammed O This O work O was O supported O by O grant O from O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81500911 B-AWARD and O No. O 81901083 B-AWARD the O Key B-ORG National I-ORG Research I-ORG Projects I-ORG on I-ORG Prevention I-ORG and I-ORG Control I-ORG of I-ORG Major I-ORG Chronic I-ORG Non-Communicable I-ORG Disease I-ORG 2018YFC1312300 O as O well O as O Fund B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG development I-ORG project I-ORG of I-ORG Jilin I-ORG province I-ORG 20180414041GH O This O work O was O supported O by O the B-ORG Water I-ORG Resources I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Provincial(RC1906 O the B-ORG Key I-ORG R&D I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Provincial I-ORG 2017C03008 O the B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Sinohydro I-ORG Bureau I-ORG 7 I-ORG Co I-ORG Ltd O 2021-749-59-4 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No O 31772519 B-AWARD No.:31720103916 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG No O 2017A030313210 B-AWARD Graduate B-ORG Student I-ORG Innovation I-ORG Program I-ORG of I-ORG South I-ORG China I-ORG Normal I-ORG University I-ORG NO O 2016kxm09 B-AWARD The O funding O bodies O had O no O role O in O the O design O of O the O study O and O collection O analysis O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31402039 O the O start-up O grant O to O Dr. O Min O Zhao O China O Scholarship O Council O CSC O Cattle O Breeding O Innovative O Research O Team O of O Chinese B-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG cxgc-ias-03 O and O National O Beef O Cattle O Industrial O Technology O System O of O China’s B-ORG Agriculture I-ORG and I-ORG Finance I-ORG Ministries I-ORG CARS-37 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O a O Burroughs B-ORG Wellcome I-ORG Fund I-ORG Career B-AWARD Award I-AWARD at I-AWARD the I-AWARD Scientific I-AWARD Interface O an O Arnold B-ORG I-ORG Mabel I-ORG Beckman I-ORG Foundation I-ORG Beckman B-AWARD Young I-AWARD Investigator I-AWARD award I-AWARD and O The O Johns B-ORG Hopkins I-ORG University I-ORG Whiting B-AWARD School I-AWARD of I-AWARD Engineering I-AWARD start-up I-AWARD funds I-AWARD to O C.L O This O study O was O funded O by O the O Leading B-ORG Project I-ORG of I-ORG the I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Fujian I-ORG Province I-ORG No. O 2016Y0101 B-AWARD the O Special B-ORG Funds I-ORG of I-ORG Provincial I-ORG Finance I-ORG of I-ORG Fujian I-ORG Province I-ORG No. O BPB-CDR2013 B-AWARD and O the O Research B-ORG Foundation I-ORG for I-ORG Young I-ORG Scholars I-ORG of I-ORG the I-ORG Health I-ORG Department I-ORG of I-ORG Fujian I-ORG Province I-ORG No. O 2013-1-34 B-AWARD This O work O was O supported O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG HG006827 B-AWARD to O CH O GM105783 B-AWARD to O APT O GM106443 B-AWARD to O QC O and O NSF-DMS-1160360 B-AWARD to O QC O and O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 91753129 B-AWARD and O 31870808 B-AWARD to O G-ZL O CH O is O an O investigator O of O the O Howard O Hughes O Medical O Institute O HHMI O LL O is O supported O by O the O China O Scholarship O Council O CSC O 201706670015 O The O Mass O Spectrometry O Facility O of O the O University O of O Chicago O is O funded O by O the O National B-ORG Science I-ORG Foundation I-ORG CHE-1048528 O This O research O was O supported O by O grants O from O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG GM116884 O and O the O Howard B-ORG Hughes I-ORG Medical I-ORG Institute I-ORG 54308198 O to O G.F.H O and O the O National B-ORG Science I-ORG Foundation I-ORG Graduate O Research O Fellowship O Grant O 1247842 O to O T.N.M O This O research O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG No. O ZR2014HP047 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Development I-ORG Project I-ORG of I-ORG Jinan I-ORG No. O 201907013 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Jinan I-ORG Health I-ORG Committee I-ORG No. O 2019-1-33 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41671275),Science O and I-ORG Technology I-ORG Fund I-ORG of I-ORG Guizhou I-ORG [2020]1Y074,ZK[2023]236 O Youth O Key O Fund O of O Sciences O Academy O of O Guizhou([2020]03),National O Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG and I-ORG the I-ORG Karst I-ORG Science I-ORG Research I-ORG Center I-ORG of I-ORG Guizhou I-ORG Province I-ORG U1812401 O Forestry O Research O of O Guizhou O Province O [2019]06 O The O funding O supporter O provided O the O cost O of O purchasing O experimental O equipment O materials O literature O and O investigation O of O this O project O This O work O was O supported O by O the B-ORG Project I-ORG of I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2017JL018 O the B-ORG China I-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M632268 O and O 2019T120404 B-AWARD and O the B-ORG Shandong I-ORG “Double I-ORG Tops” I-ORG Program I-ORG SYL2017YSTD11 O This O work O was O supported O by O a O program O of O Provincial B-ORG Department I-ORG of I-ORG Finance I-ORG of I-ORG the I-ORG Tibet I-ORG Autonomous I-ORG Region I-ORG grant O no. O XZNKY-2019-C-052 B-AWARD the O Key O Research O and O Development O Projects O in O Tibet O Preservation O of O Characteristic O Biological O Germplasm O Resources O and O Utilization O of O Gene O Technology O in O Tibet O grant O no. O XZ202001ZY0016N O the O Second O Tibetan O Plateau O Scientific O Expedition O and O Research O Program O STEP O grant O no. O 2019QZKK0501 O the B-ORG Ring-fenced I-ORG Funding I-ORG of I-ORG Finance I-ORG Department I-ORG of I-ORG Tibet I-ORG Autonomous I-ORG Region I-ORG the I-ORG earmarked I-ORG fund I-ORG for I-ORG Modern I-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG grant O no. O CARS-37 B-AWARD Basic B-ORG Research I-ORG Programs I-ORG of I-ORG Sichuan I-ORG Province I-ORG grant O no. O 2019YJ0256 B-AWARD and O the O Open O Project O Program O of O State O Key O Laboratory O of O Hulless O Barley O and O Yak O Germplasm O Resources O and O Genetic O Improvement O Tibet O Academy I-ORG of I-ORG Agricultural I-ORG and I-ORG Animal I-ORG Husbandry I-ORG and I-ORG Animal I-ORG Husbandry I-ORG Sciences O grant O no. O XZNKY-2019-C-007K10 B-AWARD We O would O like O to O thank O The B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC1600304 O MOST B-ORG 2016YFE0112900 O 201513006-02-3 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31772087 O and O Shanghai O Agriculture O Applied O Technology O Development O Program O China O 2019-02-08-00-02-F01145 O for O the O financial O support O This O study O was O financially O supported O by O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences O Grant O No. O XDA20100102 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31660347 B-AWARD and I-AWARD 31672472 O Program B-ORG for I-ORG Changjiang I-ORG Scholars I-ORG and I-ORG Innovative I-ORG Research I-ORG Team I-ORG in I-ORG University I-ORG IRT_17R50 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O Swiss B-ORG National I-ORG Science I-ORG Foundation I-ORG project I-ORG SCOPES O IZ73Z0_152454/1 O Novartis B-ORG foundation I-ORG for I-ORG medical-biological I-ORG research I-ORG Grant O No.16C197 O Serbian B-ORG Ministry I-ORG of I-ORG Science I-ORG ON175069 O and I-AWARD ON175103 O and O Faculty B-ORG of I-ORG Medical I-ORG Sciences I-ORG University I-ORG of I-ORG Kragujevac I-ORG MP01/14 O This O study O received O support O from O the O Confap-MRC O call O for O Health O Systems O Research O Networks O Specifically O GR O received O the O award O from O the O Newton O Fund/Medical O Research I-ORG Council I-ORG UK O Grant O Reference O MR/R022747/1 B-AWARD TS O received O the O award O from O Fundação O de O Amparo O à O Pesquisa O e O ao O Desenvolvimento O Científico O e O Tecnológico O do O Maranhão O FAPEMA-Brazil),COOPI-00709/18 O MCS O received O the O award O from O Fundação O de O Amparo O à O Pesquisa O do O Estado O de O São O Paulo O FAPESP-Brazil O 2017/50356-7 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O These O studies O were O supported O by O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NHLBI O HL65176 O HL134885 O National B-ORG Center I-ORG for I-ORG Research I-ORG Resources I-ORG RR024150-01 O National B-ORG Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences I-ORG UL1 O TR000135 I-AWARD UL1 I-AWARD TR002377 O and O National B-ORG Cancer I-ORG Institute I-ORG CA O 204013 O K.P O and O C.B O were O supported O by O American B-ORG Heart I-ORG Association I-ORG Postdoctoral O Fellowship O 16POST3026000 O 16POST27210011 O C.B O was O supported O by O Fundação O de O Amparo O à O Pesquisa O do O Estado O de O São O Paulo O FAPESP O 2017/21539-7 O 2018/23718-8 O The O funders O had O no O role O in O the O design O of O the O study O in O the O collection O analyses O or O interpretation O of O data O in O the O writing O of O the O manuscript O or O in O the O decision O to O publish O the O results O This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 71673254 B-AWARD The B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China-The O construction O and O promotion O of O the O demonstration O system O of O based O on O telemedicine/Mhealth O network O Grant O No. O 2017YFC0909900 B-AWARD Special O funds O from O central O government O for O the O guidance O of O local O science O and O technology O development O Construction O and O demonstration O of O telemedicine O big O data O application O system O for O precision O medicine O Special O funds O of O major B-ORG science I-ORG and I-ORG technology I-ORG project I-ORG in I-ORG Henan I-ORG province I-ORG 2016 O Construction O and O demonstration O application O of O medical O and O health O big O data O analysis O system O based O on O telemedicine O cloud O platform O Grant O No. O 151100310800 B-AWARD Doctor B-ORG research I-ORG team I-ORG fund I-ORG from I-ORG the I-ORG first I-ORG affiliated I-ORG hospital I-ORG of I-ORG Zhengzhou I-ORG University I-ORG for O the O in-hospital O Interdisciplinary O Collaboration O Research O The O impact O of O air O pollution O exposure O levels O on O lung O cancer O and O its O potential O molecular O mechanism O based O on O satellite O remote O sense O big O data O Grant O No. O 2016-BSTDJJ-15 B-AWARD This O work O has O been O supported O in O part O by O the B-ORG University I-ORG of I-ORG Rijeka I-ORG under O the O project O numbers O uniri-tehnic-18-294 B-AWARD and O uniri-prirod-18-299 B-AWARD Croatian B-ORG Science I-ORG Foundation I-ORG Project O No O IP-2018-01-3168 B-AWARD and O by O “Research O Infrastructure I-ORG for I-ORG Campus-based I-ORG Laboratories I-ORG at I-ORG the I-ORG University I-ORG of I-ORG Rijeka-RISK” O the O ERDF O project O R.C.2.2.06-0001 B-AWARD The O HAPIN O trial O is O funded O by O the O U.S B-ORG National I-ORG Institutes I-ORG of I-ORG Health I-ORG cooperative O agreement O 1UM1HL134590 B-AWARD in O collaboration O with O the O Bill B-ORG I-ORG Melinda I-ORG Gates I-ORG Foundation I-ORG OPP1131279 O Additional O support O was O provided O by O Emory’s B-ORG NIH-funded O Human O Exposome O Research O Center O P30ES019776 O This O work O was O supported O by O the O Basic B-ORG Research I-ORG Project I-ORG of O Sichuan O Province O No. O 2019YJ0690 B-AWARD the O Major B-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG in O Sichuan O Province O No. O 2019YFS0531 B-AWARD and O the O Luzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG No. O 2019-RCW-96 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O Project O Grants O GNT1064900 B-AWARD and O GNT1119940 B-AWARD awarded O to O G.T O C.F.L O D.C O N.S.-C O and O E.A O from O the O National B-ORG Medical I-ORG Research I-ORG Council I-ORG NHMRC I-ORG of I-ORG Australia O and O also O to O E.A O by O grant O R01 B-AWARD AI027690 I-AWARD from O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH O S.R O was O supported O by O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG of I-ORG the I-ORG National I-ORG Institutes I-ORG of I-ORG Health I-ORG Training I-ORG Grant O under O award O numbers O T32 B-AWARD GM008339 I-AWARD and O T32 B-AWARD GM135141 O GT O was O supported O by O NHMRC B-ORG Senior I-ORG Research I-ORG Fellowship I-ORG GNT1117748 B-AWARD This O research O was O funded O by O the O Normal B-ORG Program I-ORG supported I-ORG this I-ORG research I-ORG for I-ORG Frontiers I-ORG and I-ORG Applications I-ORG Research I-ORG of I-ORG CSTC I-ORG No. O cstc2016jcyjA0136 B-AWARD Science B-ORG and I-ORG Technology I-ORG Research I-ORG Program I-ORG of I-ORG Chongqing I-ORG Municipal I-ORG Education I-ORG Commission I-ORG KJ1712302 O Special B-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG for I-ORG Social I-ORG Undertaking I-ORG and I-ORG People’s I-ORG Livelihood I-ORG Guarantee I-ORG of I-ORG CSTC I-ORG No. O cstc2017shms-xdny80074 B-AWARD This O work O was O supported O by O Chinese B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG 2016YFD0501305 O Chinese B-ORG Special I-ORG Fund I-ORG for I-ORG Agro-scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG 201303044 O and O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-42-G11 O This O research O was O funded O by O a O grant O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31801604 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O China O 2018A030313457 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guizhou I-ORG Province O China O QKHJC[2019]1007 O the O Key O Areas O of O Science O and O Technology O Planning O Project O of O Guangdong O Province O 2018B020202011 O and O the O Key O Science O and O Technology O Planning O Project O of O Guangzhou O 2019-03-02-06-3007-0003 O This O work O was O supported O by O the O Japan O Science O and O Technology O Agency O JST O Core B-ORG Research I-ORG for I-ORG Evolutional I-ORG Science I-ORG and I-ORG Technology I-ORG CREST O grant O number O JPMJCR15Q6 B-AWARD to O TM; O Japan B-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG JSPS O KAKENHI O grant O number O JP16H06441 B-AWARD to O TM, O grant O number O JP17H02749 O to O TM; O and O Precursory B-ORG Research I-ORG for I-ORG Embryonic I-ORG Science I-ORG and I-ORG Technology I-ORG grant O number O JPMJPR15N1 B-AWARD to O IO. O This O work O was O supported O by O the O Hubei B-ORG Province I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Scientific I-ORG Research I-ORG Project I-ORG grant O number O WJ2018H178 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG grant O number O 2019CFB567 B-AWARD to O Yi O Sun O Shanghai B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG grant O number O 201940476 B-AWARD to O Lianjuan O Yang O This O work O was O financially O supported O by O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Photocatalysis I-ORG on I-ORG Energy I-ORG and I-ORG Environment I-ORG 2014C05 O the O Fujian B-ORG Provincial I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG CN) I-ORG 2015R1004-3 O and O by O Environmental B-ORG Protection I-ORG Department I-ORG of I-ORG Fujian I-ORG Province I-ORG 2015R024 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O in O part O by O the O Jiangsu B-ORG Province I-ORG Administration I-ORG of I-ORG Chinese I-ORG Medicine I-ORG ZX2016A2 O 333 B-ORG high-level I-ORG talents I-ORG training I-ORG project I-ORG in I-ORG Jiangsu I-ORG BRA O 2016507 O and O Jiangsu B-ORG Province I-ORG Hospital I-ORG of I-ORG TCM I-ORG Y2018CX66 O and O Y19054 B-AWARD Funding O support O was O used O to O organize O multiple-disciplinary-team O discussion O and O reimburse O the O travel-related O expenses O of O the O patient O during O follow-up O This O research O was O supported O by O the O Research B-ORG Fund I-ORG of I-ORG PLA I-ORG of I-ORG China I-ORG BWS17J024 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG HUST O 2019kfyRCPY B-AWARD 2019kfyXKJC019 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61233015 O and O 61473130 B-AWARD This O work O was O partially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 61701064 B-AWARD 71874027 O partially O by O the O China B-ORG Scholarship I-ORG Council I-ORG No. O 201808510008 B-AWARD partially O by O the O Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG No. O 2018GZ0454 B-AWARD partially O by O the O Chengdu O Science O and O Technology O Program O No. O 2017-RK00-00363-ZF O and O partially O by O the O Chongqing O Natural O Science O Foundation O cstc2019jcyj-msxmX0264 O This O study O was O supported O by O the B-ORG Major I-ORG Project I-ORG of I-ORG the I-ORG National I-ORG Social I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 14ZDB160 O the B-ORG major I-ORG projects I-ORG of I-ORG Humanity I-ORG and I-ORG Social I-ORG Science I-ORG base I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG in I-ORG China I-ORG 12JJD190001 O and O the B-ORG grant I-ORG from I-ORG Beijing I-ORG Social I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 12JYA003 O The O funding O agents O had O no O further O role O in O the O study O design O in O the O collection O analysis O and O interpretation O of O the O data O in O the O writing O of O the O manuscript O and O in O the O decision O to O submit O the O paper O for O publication O This O work O was O supported O in O part O by O the O National B-ORG Key I-ORG R&D I-ORG Project I-ORG of I-ORG China I-ORG 2018YFE0201600 O 2017YFC0907502 B-AWARD and O 2017YFF0204600 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31720103909 O and O Shanghai B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG 2017SHZDZX01 O and O the O 111 B-ORG Project I-ORG B13016 O Funding O for O open O access O charge O National O Key O R&D O Project O of O China O 2018YFE0201600 O The O work O was O financially O supported O by O the O following O funds O The B-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG Action I-ORG Plan I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG No.17511107900 O No.17511107901 O The B-ORG Shanghai I-ORG Three I-ORG Year I-ORG Public I-ORG Health I-ORG Action I-ORG Program I-ORG No. O GWIV-3.3 B-AWARD Research B-ORG Grant I-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG No. O 20164Y0237 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81700844 B-AWARD National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81670898 B-AWARD The B-ORG Chronic I-ORG Diseases I-ORG Prevention I-ORG and I-ORG Treatment I-ORG Project I-ORG of I-ORG Shanghai I-ORG Shen I-ORG Kang I-ORG Hospital I-ORG Development I-ORG Centre I-ORG No. O SHDC12015315 B-AWARD No. O SHDC2015644 B-AWARD The B-ORG Shanghai I-ORG Outstanding I-ORG Academic I-ORG Leader I-ORG Program I-ORG No. O 16XD1402300 B-AWARD Shanghai B-ORG Municipal I-ORG Education I-ORG Commission—Gaofeng I-ORG Clinical I-ORG Medicine I-ORG Grant I-ORG Support I-ORG No. O 20172022 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O 2016YFD0500100 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O 31500703 B-AWARD and O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Agrobiotechnology I-ORG grant O 2018SKLAB1-6 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O BG O was O supported O by O the O Engineering B-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG grant O no. O EP/J500562/1,http://www.epsrc.ac.uk B-AWARD AG O and O BG O were O supported O by O the O European O Community’s O Seventh B-ORG Framework I-ORG Programme I-ORG grant O no. O 604102 B-AWARD The O Human O Brain O Project,http://cordis.europa.eu/fp7 O AG O and O BG O were O supported O by O Horizon B-ORG 2020 I-ORG grant O no. O 284941 B-AWARD The O Human O Brain O Project,https://ec.europa.eu/programmes/horizon2020 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 71503041 O Social B-ORG Science I-ORG Fund I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG of I-ORG China I-ORG 17EYC004 O and O Zhishan B-ORG Youth I-ORG Scholar I-ORG Program I-ORG Of I-ORG SEU I-ORG 2242019R40039 O received O by O Wei O Yin,https://www.seu.edu.cn/english O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Austrian O Society O of O Urology O and O Andrology/Oesterreichische O Gesellschaft O für O Urologie O und O Andrologie O “Richard-Uebelhoer-Grant O grant O number O N/A B-AWARD awarded O to O M.S.(Maximilian O Seles O This O project O has O also O received O funding O from O the O European O Union’s O Horizon B-ORG 2020 I-ORG research O and O innovation O program O under O the O Marie O Skłodowska-Curie O grant O agreement O grant O no. O 824036 O Furthermore O this O work O received O financial O support O by O the O Czech B-ORG Ministry I-ORG of I-ORG Health I-ORG grant O no. O NV18-03-00554 B-AWARD awarded O to O O.S O C.K O received O a O Hertha-Firnberg O Grant O of O the O Austrian B-ORG Science I-ORG Fund I-ORG FWF O grant O no. O T B-AWARD 1112-B O Open O Access O Funding O by O the O Austrian O Science O Fund O FWF O This O work O has O been O supported O by O the O Czech B-ORG Science I-ORG Foundation I-ORG in O the O frame O of O project O 20-14105S B-AWARD CzechNanoLab O project O LM2018110 B-AWARD funded O by O MEYS B-ORG CR I-ORG is O gratefully O acknowledged O for O the O financial O support O of O the O measurements O and O sample O fabrication O at O CEITEC O Nano O Research O Infrastructure O The O authors O also O acknowledge O the O assistance O provided O by O The B-ORG Research I-ORG Infrastructure I-ORG NanoEnviCz I-ORG with O the O project O number O LM2018124 B-AWARD This O study O was O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O Number O 2016YFC1000304 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Number O 81671477 B-AWARD Beijing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG Grant/Award O Number O Z161100000516160 B-AWARD This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81770152 B-AWARD and O 91642111 B-AWARD the O Guangdong B-ORG Provincial I-ORG Basic I-ORG Research I-ORG Program I-ORG No. O 2015B020227003 B-AWARD the O Guangdong B-ORG Provincial I-ORG Applied I-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG I-ORG Development I-ORG Program I-ORG No. O 2016B020237006 B-AWARD and O the O Guangzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG Nos O 201510010211 B-AWARD 20180710004 B-AWARD and O 201803040017 B-AWARD This O work O was O supported O by O National O Institutes O of O Health O NIH O grants O to O Z.Q.Y O R01AI114748 B-AWARD R21AI138598 O VA B-ORG Merit I-ORG Review I-ORG Award I-ORG 1I01BX002670 B-AWARD 1I01BX004281 O and O DoD B-ORG Award I-ORG W81XWH-18-1-0327 B-AWARD This O work O was O supported O by O grants O from O the O National O Institute O of O Health O National B-ORG Institute I-ORG of I-ORG Diabetes I-ORG and I-ORG Digestive I-ORG and I-ORG Kidney I-ORG Diseases I-ORG R01DK099076 O to O MTA O the O National B-ORG Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases I-ORG R21AI24058 O to O MTA O the O Micky O O Madeleine O Arison O Family O Foundation O Crohn's O O Colitis O Discovery O Laboratory O and O Martin O Kalser O Chair O Additional O funding O was O provided O by O Grants B-AWARD for I-AWARD Laboratory I-AWARD Animal I-AWARD Science I-AWARD GLAS I-AWARD from O the O American B-ORG Association I-ORG for I-ORG Laboratory I-ORG Animal I-ORG Science I-ORG AALAS O to O JKL O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O financially O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31260473 B-AWARD Special B-ORG Fund I-ORG for I-ORG Agro-scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG 201203001 O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-25-C-07 O The O funds O were O used O for O the O provision O of O laboratory O chemicals O and O some O essential O materials O needed O for O the O experiment O At O the O time O this O research O was O conducted O this O initiative O was O funded O by O the O Health B-ORG Promotion I-ORG Foundation I-ORG of I-ORG Western I-ORG Australia I-ORG Healthway O 32146 B-AWARD Chevron B-ORG Australia I-ORG 48311 O and O the O Mental B-ORG Health I-ORG Commission I-ORG of I-ORG Western I-ORG Australia I-ORG MHC234 O This O work O was O supported O by O Key B-ORG laboratory I-ORG of I-ORG capital I-ORG medical I-ORG university I-ORG open I-ORG research I-ORG project I-ORG and I-ORG Beijing I-ORG Tuberculosis I-ORG I-ORG Thoracic I-ORG Tumor I-ORG Research I-ORG Institute I-ORG cultivation I-ORG project I-ORG Beijing I-ORG Hospital I-ORG Authority I-ORG Youth I-ORG Programme I-ORG QML20171602 O Tongzhou B-ORG District’s I-ORG Two I-ORG Supreme I-ORG Talent I-ORG YH201911 O 13th B-ORG Five I-ORG National I-ORG Major I-ORG Scientific I-ORG and I-ORG Technological I-ORG Projects I-ORG 2017ZX09304009 O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81572565 O 81572570 B-AWARD 81602291 B-AWARD 81372801 B-AWARD 81630060 B-AWARD 81230038 B-AWARD 81472783 B-AWARD the O National B-ORG Development I-ORG Program I-ORG 973 I-ORG For I-ORG Key I-ORG Basic I-ORG Research I-ORG of I-ORG China I-ORG 2015CB553903 O and O the O National B-ORG Key I-ORG Research I-ORG I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0902901 O This O work O was O supported O by O the O Scientific B-ORG Research I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Provincial I-ORG Qianfoshan I-ORG Hospital I-ORG QYPY2019NFSC0601 O Zuohui O Zhao O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81600124 O Na O Liu O and O the O Shandong B-ORG Medical I-ORG and I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Project I-ORG 2016WS0481 O Zuohui O Zhao O 2016WS0484 B-AWARD Qiang O Liu O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O design O analysis O and O interpretation O of O in O vitro O experiments O were O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No.31400646 O The O writing O of O this O manuscript O was O supported O by O Liaoning B-ORG Province I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No.201602293 O and O Liaoning B-ORG Province I-ORG Education I-ORG Department I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No.JYTQN201727 O The O data O collection O data O analysis O and O data O interpretation O were O supported O by O Biological B-ORG Anthropology I-ORG Innovation I-ORG Team I-ORG Project I-ORG of I-ORG JZMU(Grant O No.JYLJ201702 O JC O is O funded O by O UK O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG WestBio O Doctoral O Training O Partnership O 2012 O BB/J013854/1)https://bbsrc.ukri.org O RJO O and O AK O are O supported O by O the O UK O Medical B-ORG Research I-ORG Council I-ORG with O grants O MC_UU_12014/12 O and O MC_UU_12014/8 O respectivelyhttps://mrc.ukri.org O JG O and O CJM O are O funded O through O the O Strategic O Research O Programme O of O the O Rural O and O Environmental O Science O and O Analytical O Services O Division O of O the O Scottish O Government O NJ O is O supported O by O the O Department B-ORG for I-ORG Environment I-ORG Food I-ORG and I-ORG Rural I-ORG Affairs O and O the O Scottish O and O Welsh O Governments O SV3045)https://www.gov.uk/government/organisations/department-for-environment-food-rural-affairs O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O present O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31400396 B-AWARD 31802296 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG Central I-ORG Universities I-ORG No. O XDJK2018C027 B-AWARD and O the O Chongqing B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O Xm2016109 B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 82101980 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2022M722963 B-AWARD the O Fundamental B-ORG Research I-ORG Program I-ORG of I-ORG Shanxi I-ORG Province I-ORG No. O 20210302124181 B-AWARD the O Fund B-ORG Program I-ORG for I-ORG the I-ORG Scientific I-ORG Activities I-ORG of I-ORG Selected I-ORG Returned I-ORG Overseas I-ORG Professionals I-ORG in I-ORG Shanxi I-ORG Province I-ORG No. O 20220021 B-AWARD the O Startup B-ORG Foundation I-ORG for I-ORG Doctors I-ORG of I-ORG Shanxi I-ORG Medical I-ORG University I-ORG No. O XD2037 B-AWARD and O the O Scientific B-ORG and I-ORG Technological I-ORG Innovation I-ORG Programs I-ORG of I-ORG Higher I-ORG Education I-ORG Institutions I-ORG in I-ORG Shanxi I-ORG No. O 2021L239 B-AWARD This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81703419 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20170734 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2016ZPT005 O This O work O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61703305 O in O part O by O National B-ORG High-tech I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 863 I-ORG Program I-ORG of I-ORG China I-ORG 2015AA043202 O in O part O by O SPS B-ORG KAKENHI I-ORG 15K2120 O Our O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFC1001200 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81501237 B-AWARD and O 2016 B-ORG PUMCH I-ORG Science I-ORG Fund I-ORG for I-ORG Junior I-ORG Faculty I-ORG No. O PUMCH-2016-2.2 B-AWARD This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Synthetic I-ORG Biology I-ORG Research I-ORG Grant O No. O 2019YFA0905300 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 21978221 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2018M631748 B-AWARD the O Innovation B-ORG Project I-ORG of I-ORG Excellent I-ORG Doctorial I-ORG Dissertation I-ORG of I-ORG Tianjin I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Grant O No. O 2019007 B-AWARD the O Foundation B-ORG of I-ORG Key I-ORG Laboratory I-ORG of I-ORG Industrial I-ORG Fermentation I-ORG Microbiology I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG and I-ORG Tianjin I-ORG Key I-ORG Laboratory I-ORG of I-ORG Industrial I-ORG Microbiology I-ORG Grant O No. O 2018KF007 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG of I-ORG China I-ORG No. O ZR2018QC002 B-AWARD This O work O was O financially O supported O by O the B-ORG grants I-ORG from I-ORG the I-ORG Science I-ORG I-ORG Technology I-ORG Innovation I-ORG Fund I-ORG of I-ORG Gansu I-ORG Agricultural I-ORG University I-ORG GAU-XKJS-2018-168 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31760385 O 31460348 B-AWARD the B-ORG Modern I-ORG Agricultural I-ORG Industry I-ORG Technology I-ORG System I-ORG Project I-ORG of I-ORG Gansu I-ORG Province I-ORG GARS-01-04 O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Gansu I-ORG Province I-ORG 18JR3RA173 O and O the B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Gansu I-ORG Agricultural I-ORG University I-ORG GAU-KYQD-2018-41 O The O funding O agencies O only O provided O the O financial O means O to O allow O the O authors O to O carry O out O the O study O but O they O did O not O participate O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the B-ORG National I-ORG Basic I-ORG Research I-ORG Program I-ORG 973 I-ORG of I-ORG China I-ORG 2012CB722301 O the B-ORG National I-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG program I-ORG 863 I-ORG of I-ORG China I-ORG 2011AA10A203 O the B-ORG International I-ORG Cooperation I-ORG Project I-ORG 0102011DFA32610 O and O the B-ORG Cooperative I-ORG Innovation I-ORG Center I-ORG of I-ORG Engineering I-ORG and I-ORG New I-ORG Products I-ORG for I-ORG Developmental I-ORG Biology I-ORG of I-ORG Hunan I-ORG Province I-ORG 20134486 O This O work O was O supported O by O the O FWF B-ORG Austrian I-ORG Science I-ORG Fund I-ORG I O 2089];DFG O German I-ORG Research I-ORG Foundation I-ORG 265446483];Swiss O National I-ORG Science I-ORG Foundation I-ORG 10001CE-158014 O This O work O was O supported O by O the O Natural B-ORG Scientific I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31500460 B-AWARD the O Jiangxi B-ORG Academy I-ORG of I-ORG Sciences I-ORG doctoral I-ORG program I-ORG 2014-YYB-03 O and O the O Jiangxi B-ORG Academy I-ORG of I-ORG Sciences I-ORG Pratt I-ORG I-ORG Whitney I-ORG Project I-ORG 2014-XTPH1-03 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG to O BQ, O Grant O NO.81602929 O the O National O Natural O Science O Foundation O of O China O to O BQ, O Grant O NO.81973135 O Tianjin B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Key I-ORG Projects I-ORG to O MG, O Grant O No. O 17YFZCSY00690 B-AWARD Startup B-ORG Fund I-ORG for I-ORG Youngman I-ORG Research I-ORG at I-ORG SJTU I-ORG to O TF, O 17X100040015 B-AWARD and O Shanghai B-ORG Jiao I-ORG Tong I-ORG University I-ORG Medical I-ORG and I-ORG Industrial I-ORG Cross I-ORG Project I-ORG to O TF, O YG2017QN70 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 51805371 B-AWARD the O Tianjin B-ORG Natural I-ORG Science I-ORG Foundation I-ORG grant O nos O 18JCTPJC67300 B-AWARD and O 18JCYBJC96200 B-AWARD and O the O Tianjin B-ORG University I-ORG of I-ORG Commerce I-ORG Foundation I-ORG grant O no. O 2017CGZH0226 B-AWARD is O greatly O acknowledged O This O work O was O funded O by O Zhejiang B-ORG Medical I-ORG and I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 2018PY079 O Joint B-ORG Research I-ORG Project I-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Pudong I-ORG New I-ORG Area I-ORG Health I-ORG Commission I-ORG PW2020D-7 O and O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG 20ZR1431500 O Science O Foundation O of O Enze O Medical O Center O Group O 20EZD61 O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0300704 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31901864 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG C2019204141 O the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-02-25 O and O a O Starting B-ORG Grant I-ORG from I-ORG Hebei I-ORG Agricultural I-ORG University I-ORG ZD201721 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31370811 O the O National B-ORG Key I-ORG Technology I-ORG Support I-ORG Program I-ORG 2013BAB01B01 O and O the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2011AA10A205 O Dr. O Heng O Yin O was O supported O by O the O CAS B-ORG Youth I-ORG Innovation I-ORG Promotion I-ORG Association I-ORG 2015144 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O Youth B-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O 81601915 B-AWARD awarded O to O Pei O Shen O Science O and O Technology O Commission O of O Shanghai O Funding/Supporting O 16411960900 O The B-ORG New I-ORG Frontier I-ORG Technology I-ORG Joint I-ORG Research I-ORG Project I-ORG of I-ORG Shanghai I-ORG grant O SHDC12017101 B-AWARD awarded O to O Dr. O Chi O Yang O and O Shanghai O Summit O O Plateau O Disciplines O and O the O Municipality B-ORG Science I-ORG Research I-ORG Project I-ORG grant O JYLJ003 B-AWARD awarded O to O Dr. O Chi O Yang O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 42230712 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG CHD O grant O number O 300102261719 B-AWARD Natural B-ORG Science I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG Shaanxi I-ORG Province O grant O number O 2021JM-535 B-AWARD and O Special B-ORG Fund I-ORG for I-ORG Scientific I-ORG Research I-ORG by I-ORG Xijing I-ORG University O grant O number O XJ18T01 B-AWARD Experimental O work O was O supported O by O the O National B-ORG Key I-ORG R I-ORG and I-ORG D I-ORG Program I-ORG of I-ORG China I-ORG 2021YFD1300800 O and O 2020YFA0509500 B-AWARD the O Science B-ORG Foundation I-ORG of I-ORG the I-ORG Sichuan I-ORG Province I-ORG 2021YFS0008 O and O 2022YFQ0022 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2021M692329 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32070405 O 32270444 B-AWARD 32200407 B-AWARD and O 32001228 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2022M711884 O the O Youth B-ORG Innovation I-ORG Team I-ORG of I-ORG Shandong I-ORG Universities I-ORG 2022KJ177 O the O Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG ZR2021YQ22 O the O Shandong B-ORG Postdoctoral I-ORG Innovation I-ORG Project I-ORG SDCX-ZG-202203027 O and O the O Shandong B-ORG Province I-ORG Colleges I-ORG and I-ORG Universities I-ORG Youth I-ORG Innovation I-ORG Science I-ORG and I-ORG Technology I-ORG Teams I-ORG Support I-ORG Program I-ORG 2021KJ015 O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 52074111 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG grant O number O YQ2020E034 B-AWARD post–doctoral B-ORG funded I-ORG projects I-ORG in I-ORG Heilongjiang I-ORG Province I-ORG grant O number O LBH–Z22248 B-AWARD and O the O development B-ORG of I-ORG key I-ORG technologies I-ORG for I-ORG coal I-ORG mine I-ORG fire I-ORG prevention I-ORG and I-ORG major I-ORG disaster I-ORG monitoring I-ORG grant O number O 2020ZX04A01 B-AWARD The O work O was O supported O by O Shenzhen B-ORG Peacock I-ORG Plan I-ORG Program I-ORG KQCX20140521144358003 O Fundamental B-ORG Research I-ORG Program I-ORG of I-ORG Shenzhen I-ORG JCYJ20140417172417144 O International B-ORG Collaboration I-ORG Program I-ORG of I-ORG Shenzhen I-ORG GJHZ20150312114008636 O and O Innovative O group O for O high-performance O lithium-ion O power O batteries O R&D O and O industrialization O of O Guangdong O Province O Grant O No. O 2013N079 O Shenzhen B-ORG Technology I-ORG Innovation I-ORG Program—Technology I-ORG Development I-ORG Projects I-ORG Grant O No. O CXZZ20140904154839135 B-AWARD This O study O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFC0302500 B-AWARD the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 41476104 B-AWARD and I-AWARD 31460001 O the O Youth B-ORG Innovation I-ORG Promotion I-ORG Association I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Y710071001 O and O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG B I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Nos O XDB06010201 B-AWARD and I-AWARD XDB06040101 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O is O supported O by O the O Key B-ORG Project I-ORG of I-ORG Chinese I-ORG National I-ORG Development I-ORG Programs I-ORG Grant O No. O 2016YFB0400901 B-AWARD the O Key B-ORG Laboratory I-ORG of I-ORG infrared I-ORG imaging I-ORG materials I-ORG and I-ORG detectors I-ORG Shanghai I-ORG Institute I-ORG of I-ORG Technical I-ORG Physics I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Grant O No. O IIMDKFJJ-17-09 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 61774065 B-AWARD and O the O Director O Fund O of O WNLO O This O study O was O supported O by O the O Key B-ORG Scientific I-ORG Research I-ORG Projects I-ORG in I-ORG Colleges I-ORG and I-ORG Universities I-ORG of I-ORG Henan I-ORG Province I-ORG 18A330003 O to O JW) O and O the O Medical B-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG nos O A2016213 I-AWARD and I-AWARD A2018312 O both O to O KG O the O Science B-ORG and I-ORG Technology I-ORG Development I-ORG Foundation I-ORG of I-ORG Shenzhen I-ORG JCYJ20170818100842319 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O research O concerning O MZF1 O function O in O cancer O in O TK O group O has O been O financially O supported O by O Novo B-ORG Nordisk I-ORG Foundation I-ORG NNF15OC0017324 O the O Danish B-ORG Medical I-ORG Research I-ORG Council I-ORG 0602-02386B O the O Danish O Cancer O Society O Scientific O Committee O KBVU O R124-A7854-15-S2 O and O R56-A3108-12-S2 O and O the O Danish B-ORG National I-ORG Research I-ORG Foundation I-ORG DNRF125 O This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0500503 O and O 2018YFD0500404 B-AWARD the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31730090 O and O Hubei B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 2018CFA020 O The O present O work O was O supported O by O the O GINOP B-ORG 2.3.2-15-2016-00047 B-AWARD the O NKFIH B-ORG FK129190 B-AWARD the O UNKP-18-4-PTE-364 B-AWARD New B-ORG National I-ORG Excellence I-ORG Program I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Human I-ORG Capacities O the O “Institutional O Excellence I-ORG Program I-ORG 2018” O 17886-4/2018 O FEKUTSTRAT O grants O and O the O University B-ORG of I-ORG Pécs I-ORG Medical I-ORG School O KA-2018-17 B-AWARD research O grant O This O research O was O supported O by O Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG China I-ORG Grant O NO. O ZR2016HB37 B-AWARD the O Shandong B-ORG Medical I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Plan I-ORG Project I-ORG NO. O 2017WS433 B-AWARD and O 2017WSA01044 B-AWARD Science B-ORG and I-ORG technology I-ORG projects I-ORG of I-ORG Jinan I-ORG health I-ORG and I-ORG family I-ORG planning I-ORG commission I-ORG NO. O 2016-1-50 B-AWARD This O work O was O supported O by O Fundação B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG a I-ORG Tecnologia I-ORG FCT O by O funding O the O research O project O ILSurvive O PTDC/EMD-TLM/3253/2020 O and O the O Research B-ORG Unit I-ORG INESC I-ORG MN I-ORG UID/05367/2020 O through O BASE O and O PROGRAMATICO O financing O This O work O was O developed O within O the O scope O of O the O project O CICECO-Aveiro O Institute O of O Materials O UIDB/50011/2020 B-AWARD UIDP/50011/2020 B-AWARD and O LA/P/0006/2020 B-AWARD financed O by O national O funds O through O the O FCT/MEC B-ORG PIDDAC O F.A.eS O acknowledges O FCT—Fundação O para O a O Ciência O e O a O Tecnologia O I.P O for O the O researcher O contract O CEECIND/03076/2018 B-AWARD under O the O Scientific B-ORG Employment I-ORG Stimulus—Individual I-ORG Call I-ORG 2018 I-ORG This O work O was O supported O by O grants O from O the O Education B-ORG Department I-ORG of I-ORG Jilin I-ORG Province I-ORG P.R.C O No. O JJKH20190059KJ O the O Science B-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Jilin I-ORG Province I-ORG P.R.C O No. O 20180520111JH O the O Science O and O Technology O Department O of O Jilin O Province O P.R.C O No. O 20190201050JC O and O the O Second B-ORG Hospital I-ORG of I-ORG Jilin I-ORG University I-ORG P.R.C O KYPY2018-02 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Experiments O in O the O authors O laboratory O are O supported O by O theWellcome O Trust(grant O no.109680/Z/15/Z O theRoyal O Society(grant O no.RG150386 O andTenovus O Scotland(grant O no.G14/19 O to O SS. O VSC O is O recipient O of O aEuropean O Union's I-ORG Horizon I-ORG 2020 I-ORG research I-ORG and I-ORG innovation I-ORG program I-ORG Marie I-ORG Sklodowska I-ORG Curie I-ORG Fellowship(grant O no.706040 O This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81672183 B-AWARD 81501919 O Peking B-ORG University I-ORG People’s I-ORG Research I-ORG Development I-ORG Funds I-ORG No.2127000091 O and O Technology B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Projects I-ORG of I-ORG Beijing I-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG China I-ORG No. O Z181100001818008 B-AWARD D171100003217002 I-AWARD Z171100002717094 O This O work O was O supported O in O part O by O grants O from O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Number O 81273643 B-AWARD and O Guangdong B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG Grant O Number O 2014B050502013 B-AWARD to O JS, O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O Number O 2015M570699 B-AWARD and I-AWARD 2016T90773 O Guangdong B-ORG Provincial I-ORG Science I-ORG Foundation I-ORG Grant O Number O 2015A030310107 B-AWARD and O Guangdong B-ORG Provincial I-ORG Medicine I-ORG Science I-ORG Foundation I-ORG Grant O Number O A2016315 B-AWARD to O BH, O Foundation B-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG Bureau I-ORG of I-ORG Guangdong I-ORG Province I-ORG Grant O Number O 20141074 B-AWARD to O QW, O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG 2014J4500037 O to O YG, O and O by O the O Division O of O Intramural O Research O National O Institute O of O Allergy O and O Infectious O Diseases O National O Institutes O of O Health O XzS O The O funds O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O the O preparation O of O the O manuscript O This O project O was O funded O by O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2016M601922 O 2018T110577 O the O Open O Project O of O State O Key O Laboratory O of O Natural O Medicines O SKLNMKF201708 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31270787 O 81703637 O This O research O was O also O supported O by O the O Program B-ORG for I-ORG Changjiang I-ORG Scholars I-ORG and I-ORG Innovative I-ORG Research I-ORG Team I-ORG in I-ORG University I-ORG IRT_15R63 O 111 O Project O from O Ministry O of O Education O of O China O and O the O State O Administration O of O Foreign O Export O Affairs O of O China O B18056 O and O Natural O Science O Fund O in O Jiangsu O Province O BK20170736 O This O study O was O sponsored O by O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG MOST104-2320-B-039-006 O China B-ORG Medical I-ORG University I-ORG CMU105-ASIA-08 O CMU106-ASIA-20 O and O CMU O under O the O Aim O for O Top B-ORG University I-ORG Plan I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG Taiwan I-ORG and I-ORG Taiwan I-ORG Ministry I-ORG of I-ORG Health I-ORG and I-ORG Welfare I-ORG Clinical I-ORG Trial I-ORG and I-ORG Research I-ORG Center I-ORG of I-ORG Excellence I-ORG MOHW104-TDU-B-212-113002 O This O research O was O jointly O supported O by O the O grants O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32273184 O Hainan B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG ZDYF2022XDNY246 O 420QN339 B-AWARD the B-ORG Central I-ORG Public-Interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG for I-ORG Chinese I-ORG Academy I-ORG of I-ORG Tropical I-ORG Agricultural I-ORG Sciences I-ORG 19CXTD-32 O and O the B-ORG Shandong I-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG ZR2019BC102 O This O study O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG Grant O No. O ZR2016CL17 B-AWARD Supporting O Fund O for O Teachers’ B-ORG research I-ORG of I-ORG Jining I-ORG Medical I-ORG University I-ORG Grant O No.JYFC2018KJ021 O Doctoral B-ORG Funding I-ORG of I-ORG Jining I-ORG Medical I-ORG University I-ORG Grant O No. O JY2015BS15 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O no. O 31072191 B-AWARD and O 31372506 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O Cancer B-ORG Research I-ORG UK I-ORG C10701/A15181 O Worldwide B-ORG Cancer I-ORG Research I-ORG 15-0168 O and O the O Medical B-ORG Research I-ORG Council I-ORG MR/M01939X/1 O This O work O was O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG Project I-ORG of I-ORG China I-ORG no. O 31301899 B-AWARD no. O 31501876 B-AWARD and O no. O 31872272 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanxi I-ORG no. O 201601D021122 B-AWARD and O Shanxi B-ORG Agricultural I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG fund I-ORG projects I-ORG 2015YJ03 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O work O was O supported O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG R01-GM117839 O to O M.T O P30-RR032135 B-AWARD and O P30-GM103498 B-AWARD for O the O Neuroscience O COBRE O Imaging O Facility O the O University O of O Vermont O Larner O College O of O Medicine O Bridge O Support O Grant O to O M.T O the O University O of O Vermont O Department O of O Microbiology O O Molecular O Genetics O Nicole O J. O Ferland O Award O to O S.P O the O Medical B-ORG Research I-ORG Council I-ORG CSF O MR/P008801/1 I-AWARD to O N.J.M O NHS B-ORG Blood I-ORG and I-ORG Transplant I-ORG WPA15-02 O to O N.J.M O the O NIHR O Cambridge O BRC O and O a O Wellcome B-ORG Trust I-ORG Strategic B-AWARD Award I-AWARD to O CIMR O The O contents O are O solely O the O responsibility O of O the O authors O and O do O not O necessarily O represent O the O official O views O of O these O funding O sources O This O work O was O supported O by O the B-ORG science I-ORG and I-ORG technology I-ORG department’s I-ORG major I-ORG program I-ORG of I-ORG Henan I-ORG China I-ORG 161100311100 O the B-ORG national I-ORG health I-ORG and I-ORG family I-ORG planning I-ORG commission I-ORG in I-ORG China I-ORG 201601010 O The B-ORG education I-ORG department’s I-ORG Project I-ORG of I-ORG Henan I-ORG China I-ORG 19A320052 O The O funders O had O no O role O in O study O design O data O collection O analysis O and O interpretation O preparation O of O the O manuscript O or O decision O to O submit O the O article O for O publication O This O research O was O funded O by O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation O grant O number O “2021M703471” O National B-ORG Science I-ORG Foundation I-ORG of I-ORG Xinjiang I-ORG Uygur I-ORG Autonomous I-ORG Region O grant O number O “2022D01B216” O The B-ORG Third I-ORG Xinjiang I-ORG Scientific I-ORG Expedition I-ORG Program O grant O number O “2021xjkk0500” O This O research O was O funded O by O Science B-ORG Foundation I-ORG for I-ORG Youths I-ORG of I-ORG Hebei I-ORG Province O No. O E2021202010 B-AWARD Fund O for O Innovative O Research O Groups O of O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province O No. O A2020202002 B-AWARD China B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program O No. O 2022YFC36014000 B-AWARD This O publication O is O a O contribution O of O the O Mississippi O Agricultural O and O Forestry O Experiment O Station O Starkville O MS O The O authors O gratefully O acknowledge O the O financial O support O of O the O U.S B-ORG Agency I-ORG for I-ORG International I-ORG Development I-ORG USAID O via O the O Peanut O Mycotoxin O Innovation O Laboratory O PMIL O at O the O University O of O Georgia O Subaward O No. O RC710-059/4942206 B-AWARD and O USDA B-ORG cooperative I-ORG agreement I-ORG No. O 58-6054-8-009 B-AWARD This O material O is O also O based O upon O work O that O is O supported O by O the O National B-ORG Institute I-ORG of I-ORG Food I-ORG and I-ORG Agriculture O U.S O Department O of O Agriculture O Hatch O multistate O project O under O accession O number O 1018484 B-AWARD This O work O was O supported O by O the B-ORG Talent I-ORG Introduction I-ORG Research I-ORG Project I-ORG for I-ORG Huaiyin I-ORG Institute I-ORG of I-ORG Technology I-ORG Z301B19573 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31801829 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20170463 O BK20170462 B-AWARD BK20181062 B-AWARD the B-ORG Natural I-ORG Science I-ORG Research I-ORG Project I-ORG in I-ORG Colleges I-ORG of I-ORG Jiangsu I-ORG Province I-ORG of I-ORG China I-ORG 18KJD210001 O This O study O was O solicited O by O the O Caribbean O Institute O for O Meteorology O and O Hydrology O CIMH O through O the O United O States O Agency O for O International O Development's O USAID O Grant O ID: O AID-538-10-14-00001 B-AWARD Programme O for O Building O Regional O Climate O Capacity O in O the O Caribbean O BRCCC O Programme O rcc.cimh.edu.bb/brccc O with O funding O made O possible O by O the O generous O support O of O the O American O people O RL O was O supported O by O a O Royal B-ORG Society I-ORG Dorothy B-AWARD Hodgkin I-AWARD Fellowship O AG O was O supported O by O a O grant O from O the O Medical B-ORG Research I-ORG Council I-ORG UK O Grant O ID: O MR/M022625/1 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O National B-ORG Key I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O number O 2015BAD15B05 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Numbers O 31470210 B-AWARD 31570029 B-AWARD and O 31670735 B-AWARD and O the O Shandong B-ORG Province I-ORG Key I-ORG Laboratory I-ORG Union I-ORG of I-ORG Carbohydrate I-ORG Industry I-ORG Science I-ORG and I-ORG Technology I-ORG Grant O Number O 2015LKH102 B-AWARD This O study O was O supported O by O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-10-B22 O the O National B-ORG Key I-ORG Technology I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2015BAD15B01 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG for I-ORG Youth I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 31400685 B-AWARD and O 21606218 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG for I-ORG General I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31770395 B-AWARD Science B-ORG I-ORG Technology I-ORG Program I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2017NZ0018 O and O 2017HH0077 B-AWARD Key B-ORG Laboratory I-ORG of I-ORG Environmental I-ORG and I-ORG Applied I-ORG Microbiology I-ORG Chengdu I-ORG Institute I-ORG of I-ORG Biology I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Nos O KLEAMCAS201501 B-AWARD KLCAS-2016-02 B-AWARD and O KLCAS-2016-06 B-AWARD This O work O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China O grant O number O 2022YFD1700103 B-AWARD the O Carbon B-ORG Peak I-ORG Carbon I-ORG Neutralization I-ORG Science I-ORG and I-ORG Technology I-ORG In-novation I-ORG Special I-ORG Fund I-ORG of I-ORG Jiangsu I-ORG Province O grant O number O BE2022303 B-AWARD and O the O Foreign B-ORG Experts I-ORG Program I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG the I-ORG People’s I-ORG Republic I-ORG of I-ORG China O grant O number O G2022051018L B-AWARD This O work O was O supported O by O Beijing B-ORG Nova I-ORG Program I-ORG Z181100006218085 O Opening O Foundation O of O State O Key O Laboratory O of O Kidney O Diseases O KF-01-115 O Opening O Foundation O of O National O Clinical O Research O Center O of O Geriatrics O NCRCG-PLAGH-2017017 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81773502 O 81703285 O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 7174350 O Special O Foundation O for O the O Cultivation O of O Excellent O Youth O Science O in O PLA O General O Hospital O 2017-YQPY-003 O Military O Fund O 15BJZ41 O 17BJZ51 O Medical O Big O Data O Fund O of O Chinese O PLA O General O Hospital O 2018MBD-029 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51772016 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG XK1802-2 O and O Joint B-ORG Fund I-ORG of I-ORG Shandong I-ORG Natural I-ORG Science I-ORG Foundation I-ORG ZR2021LFG015 O This O research O was O funded O by O the O Program O for O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 91647118 B-AWARD 51839002 B-AWARD and O 51809020 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG province O grant O number O 2018JJ3549 B-AWARD 2018JJ3535 B-AWARD and O the O Hunan B-ORG Provincial I-ORG Innovation I-ORG Foundation I-ORG for I-ORG Postgraduates O grant O number O CX2018B539 B-AWARD This O research O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31601434 O the O Major B-ORG Projects I-ORG of I-ORG Technological I-ORG Innovation I-ORG of I-ORG Hubei I-ORG Province I-ORG 2017ABA148 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2016T90701 O This O study O was O sponsored O by O grants O from O the B-ORG National I-ORG S&T I-ORG Major I-ORG Project I-ORG No. O 2012ZX10002017 B-AWARD the B-ORG Foundation I-ORG for I-ORG Innovative I-ORG Research I-ORG Groups I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81121002 B-AWARD and O Medical B-ORG and I-ORG health I-ORG platform I-ORG project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG A I-ORG level I-ORG backbone I-ORG talent I-ORG Grant O No. O 2015RCA010 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O We O acknowledge O funding O from O Global O Partnership O Fund O grant O University O of O Warwick O Newton B-ORG Fund—Institutional O Links I-AWARD grant I-AWARD ID I-AWARD 352360246 O Engineering B-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG grant O EPSRC O EP/R00403X/1 B-AWARD Medical B-ORG Research I-ORG Council I-ORG as O part O of O an O Interdisciplinary O Biomedical O Research O Doctoral O Training O Programme O MR/R502212/1 B-AWARD and O Universitas B-ORG Indonesia I-ORG grant O PITQQ B-AWARD NKB.0330/UN2.R3.1/HKP.05.00/2019 O We O would O also O like O to O thank O Emma O Proctor O for O the O fabrication O of O the O devices O using O the O UV O LED O set-up O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31372045 O the O Earmarked B-ORG Fund I-ORG for I-ORG the I-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-29 O the O Science B-ORG Foundation I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scientists I-ORG in I-ORG Jiangsu I-ORG Province I-ORG BK20150025 O and O ‘333 O high-level O talents O training O project’ O in O Jiangsu O Province O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81801007 O the O Postdoctoral B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 2019M652980 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2018A030310442 O and O the O Science B-ORG and I-ORG Cultivation I-ORG Foundation I-ORG of I-ORG Stomatological I-ORG Hospital I-ORG of I-ORG Southern I-ORG Medical I-ORG University I-ORG PY2018027 O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81173061 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG of I-ORG China I-ORG ZR2017MH048 O ZR202111120207 B-AWARD the O Academic B-ORG Promotion I-ORG Programme I-ORG of I-ORG Shandong I-ORG First I-ORG Medical I-ORG University I-ORG 2019LJ003 O and O the O Collaborative B-ORG Innovation I-ORG Center I-ORG for I-ORG Research I-ORG and I-ORG Development I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG in I-ORG Mount I-ORG Tai O zd099 O This O work O was O supported O by O the O Comisión B-ORG Nacional I-ORG de I-ORG Investigación I-ORG Científica I-ORG y I-ORG Tecnológica I-ORG FONDECYT O 11130697 I-AWARD to O Gonzalo O A. O Collado O and O FONDECYT B-AWARD 1140540 I-AWARD to O Marco O A O Méndez O Proyecto B-ORG de I-ORG Cooperación I-ORG Internacional I-ORG ECOS-CONICYT I-ORG C15B02 B-AWARD granted O to O Marco O A. O Méndez O and O Nicolas O Puillandre O CONICYT-FONDEQUIP B-ORG Program I-ORG No. O EQM-140088 B-AWARD to O Gonzalo O A. O Collado O and O Beca B-ORG Nacional I-ORG de I-ORG Doctorado I-ORG CONICYT-PCHA/Doctorado O Nacional/2014-21140226 I-AWARD to O Moisés O A. O Valladares O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 61601151 B-AWARD 61701143 B-AWARD 61673143 B-AWARD 81872396 B-AWARD and O 81572935 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG grant O number O C2016037 B-AWARD and O the O Joint B-ORG Scientific I-ORG and I-ORG Technology I-ORG Innovation I-ORG Fund I-ORG of I-ORG Fujian I-ORG Province I-ORG grant O number O 2016Y9044 B-AWARD This O work O was O supported O by O the O Engineering B-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG EP/P02081X/1 O European B-ORG Cooperation I-ORG in I-ORG Science I-ORG and I-ORG Technology I-ORG SARCOS O CA15202 O H2020 B-ORG Marie I-ORG Skłodowska-Curie I-ORG Actions I-ORG 860006 O Ministry B-ORG of I-ORG Land I-ORG Infrastructure I-ORG and I-ORG Transport I-ORG of O the O Korean O government O 19SCIP-B103737-05 O The O work O was O fully O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81501872 B-AWARD Distinguished B-ORG Middle-Aged I-ORG and I-ORG Young I-ORG Scientist I-ORG Encourage I-ORG and I-ORG Reward I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG No. O BS2014YY034 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2016M592144 O China O Postdoctoral O Science O Foundation O 2016M590621 O This O work O was O supported O by O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG www.cihr-irsc.gc.ca O grant O number O RNL126468 B-AWARD Research B-ORG and I-ORG Development I-ORG Corporation I-ORG of I-ORG Newfoundland I-ORG and I-ORG Labrador I-ORG http://www.rdc.org O grant O number O 5404.1033104 B-AWARD and O Canadian B-ORG Breast I-ORG Cancer I-ORG Foundation I-ORG http://www.cbcf.org/Pages/default.aspx O grant O number O 208641 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O project O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31602041 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFD0501200 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 2019QNA6025 B-AWARD and O the O Zhejiang B-ORG Province I-ORG Public I-ORG Welfare I-ORG Technology I-ORG Application I-ORG Research I-ORG Project I-ORG LGN20C180005 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31871675 I-AWARD and I-AWARD 31700438 O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG No. O CARS-16-E22 B-AWARD Chinese B-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG No. O ASTIP-IBFC08 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG No. O 2019JJ40331 B-AWARD and I-AWARD 2019JJ50711 O The O funder O had O no O direct O role O in O the O design O and O conduct O of O the O study O collection O management O analysis O and O interpretation O of O the O data O preparation O review O or O approval O of O the O manuscript O or O the O decision O to O submit O the O manuscript O for O publication O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 61975155 B-AWARD Major B-ORG Projects I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG No. O 17JC1400800 B-AWARD and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG JUSRP21935 O This O work O was O performed O under O the O auspices O of O the O U.S O Department O of O Energy O by O Lawrence B-ORG Livermore I-ORG National I-ORG Laboratory I-ORG under O Contract O DE-AC52-07NA27344 O Funding O was O provided O through O LLNL O LDRD-ER O 17-ER-019 B-AWARD to O MKB O The O macaque O work O performed O was O supported O by O a O CNPRC O pilot O research O grant O to O LC O and O KVR O start-up O funds O from O the O Pathology O Microbiology O and O Immunology O Department O University O of I-ORG California I-ORG Davis O to O LC, O NIAID O 1R21AI129479-01 B-AWARD to O KVR O and O the O Office O of O Research O Infrastructure O Programs/OD O P51OD011107 O to O the O California B-ORG National I-ORG Primate I-ORG Research I-ORG Center O This O work O was O also O supported O by O U.S B-ORG Food I-ORG and I-ORG Drug I-ORG Administration I-ORG HHSF223201610542P B-AWARD to O LC. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo-FAPESP I-ORG FAPESP O 2019/26854-2 B-AWARD 2014/22689-3 B-AWARD Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq–Bolsa O Produtividade O em O Pesquisa O 314166/2021-1 B-AWARD and O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG Capes O code B-AWARD 1. I-AWARD This O research O was O supported O by O KBRI O basic O research O program O through O Korea B-ORG Brain I-ORG Research I-ORG Institute I-ORG funded O by O the O Ministry O of O Science O and O ICT O 17-BR-02 O Basic O Science O Research O Program O through O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O funded O by O the O Ministry O of O Science O ICT O and O Future O Planning O NRF-2013R1A1A3012721 O and O the O Korea O Health O Technology O R&D O Project O through O the O Korea B-ORG Health I-ORG Industry I-ORG Development I-ORG Institute I-ORG KHIDI O funded O by O the O Ministry O of O Health O and O Welfare O South O Korea O H O I14C1135 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O Clinical B-ORG Research I-ORG Fund I-ORG from I-ORG Zhongshan I-ORG Hospital I-ORG of I-ORG Fudan I-ORG University I-ORG 2016ZSLC05 O to O Shanghai O Respiratory O Research O Institute O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81772720 O to O Changhai O Hospital O and O Research B-ORG Funding I-ORG from I-ORG Jiangsu I-ORG Commission I-ORG of I-ORG Health I-ORG BM2018023-3 O to O Jiangyuan O Hospital O The O study O was O partially O sponsored O by O Lisen O Imprinting O diagnostics O Inc O This O research O was O partially O supported O by O the O Gulf B-ORG of I-ORG Mexico I-ORG Research I-ORG Initiative I-ORG GoMRI O under O grant O no. O SA12-03/GoMRI-003 B-AWARD ARO B-ORG under O grant O no. O W911NF-20-1-0307 B-AWARD ONR B-ORG under O grant O no. O N00014-21-1-2834 B-AWARD and O the O Cancer B-ORG Prevention I-ORG Research I-ORG Institute I-ORG for I-ORG Texas I-ORG CPRIT O under O grant O no. O RP200593 B-AWARD Microfabrication O and O material O characterization O instrument O was O partially O supported O by O ARO O under O grant O no. O W911NF-17-1-0371 B-AWARD Portions O of O this O work O were O conducted O in O the O Minnesota O Nano O Center O supported O by O National B-ORG Science I-ORG Foundation I-ORG under O grant O no. O ECCS-1542202 B-AWARD This O research O was O funded O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2021YFB2800702 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2232022A-11 O Zhejiang B-ORG Lab I-ORG No. O 2021MB0AB01 O Shanghai B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Project I-ORG 21ZR1402200 O 21ZR1473800 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O nos O 51922082 B-AWARD 51971170 B-AWARD the O 111 B-ORG Project I-ORG of I-ORG China I-ORG 2.0 I-ORG grant O no. O BP0618008 B-AWARD and O the O Shaanxi B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG grant O no. O 2022QFY10-03 B-AWARD This O work O was O supported O by O the O NIH B-AWARD RO1 I-AWARD NS033300 I-AWARD grant O to O RLM B-ORG and O the O NIH B-AWARD U01HG007703 I-AWARD grant O to O VN B-ORG and I-ORG KR. O The O Nanion O SyncroPatch O 384PE O is O housed O and O managed O within O the O University O of O Michigan O Center O for O Chemical O Genomics O CCG O high-throughput O screening O core O facility O and O was O funded O by O NIH B-ORG Shared I-ORG Instrumentation I-ORG Grant O 1S10OD025203 B-AWARD This O work O was O supported O by O the O Natural B-ORG Sciences I-ORG and I-ORG Engineering I-ORG Council I-ORG of I-ORG Canada I-ORG grant O number O PGSD3-487581-2016 B-AWARD and O SYNTHESYS B-ORG Project I-ORG FR-TAF-6577 O to O Michela O Johnson O and O a O Leverhulme B-ORG Trust I-ORG Research I-ORG Project I-ORG grant O number O RPG-2017-167 B-AWARD to O Stephen O Brusatte O and O Mark O Young O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Scientific I-ORG Foundation O China O 81170322 O 81571361 O U1632120 O Shanghai B-ORG Natural I-ORG Scientific I-ORG Foundation O China O 11ZR1405300 O and O Shanghai B-ORG Municipal I-ORG Outstanding I-ORG Talent I-ORG Development I-ORG Foundation I-ORG 2012052 O This O work O was O supported O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 81471488 O 81502157 B-AWARD 81271378 B-AWARD 81501291 B-AWARD Key B-ORG medical I-ORG subjects I-ORG of I-ORG Jiangsu I-ORG province I-ORG XK201120 O Jiangsu B-ORG Province I-ORG key I-ORG research I-ORG and I-ORG development I-ORG of I-ORG special I-ORG funds I-ORG BE2015644 O Key B-ORG Laboratory I-ORG of I-ORG Suzhou I-ORG City I-ORG SZS201108 O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Suzhou I-ORG SYSD2013105 O SYS201446 B-AWARD SYS201441 B-AWARD Public B-ORG health I-ORG technology I-ORG project I-ORG of I-ORG Suzhou I-ORG SS201536 O and O the B-ORG Department I-ORG of I-ORG Pediatrics I-ORG Clinical I-ORG Center I-ORG of I-ORG Suzhou I-ORG Szzx201504 O This O work O was O supported O by O Jiangsu B-ORG Provincial I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Foundation I-ORG BE2016608 O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81702151 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20170121 O and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 021414380306 O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 42177274 O 31870504 B-AWARD and O 31870111 B-AWARD the O Second B-ORG Tibetan I-ORG Plateau I-ORG Scientific I-ORG Expedition I-ORG and I-ORG Research I-ORG Program I-ORG 2019QZKK0308 O and O 2019QZKK0306 B-AWARD and O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Urban I-ORG and I-ORG Regional I-ORG Ecology I-ORG SKLURE2022-1-3 O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31772566 O the O State B-ORG Scholarship I-ORG Fund I-ORG of I-ORG China I-ORG Scholarship I-ORG Council I-ORG 201808340031 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Province I-ORG 1708085MC61 O the O Anhui B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 1804a07020128 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31900416 O and O Shanghai B-ORG Committee I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 18140900501 O and O Postdoctoral B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 2019M651548 O and O Hainan O Provincial O Natural O Science O Foundation O of O China O 2019RC358 O This O research O was O supported O by O the O Medical B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG through O grant O number O A2017404(to B-AWARD Jingyuan O Hou O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Meizhou I-ORG through O grant O number O 2018B024(to B-AWARD Jingyuan O Hou O Key B-ORG Scientific I-ORG and I-ORG Technological I-ORG Project I-ORG of I-ORG Meizhou I-ORG People’s I-ORG Hospital I-ORG through O grant O number O MPHKSTP-20180101(to B-AWARD Zhixiong O Zhong O Key O Scientific O and O Technological O Project O of O Meizhou O People’s O Hospital O through O grant O number O MPHKSTP-20170102(to B-AWARD Zhixiong O Zhong O This O work O was O supported O in O part O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81702919 B-AWARD and O Guangxi B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 2017JJB10161 B-AWARD and O grants O from O Guangxi B-ORG Zhuang I-ORG Region I-ORG Health I-ORG Department I-ORG No. O Z2015234 B-AWARD and O No. O Z20190311 B-AWARD This O study O was O supported O by O the B-ORG Creative I-ORG Item I-ORG of I-ORG Innovative I-ORG Team I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG No. O IRT-13R63 B-AWARD National B-ORG Training I-ORG Programs I-ORG of I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG for I-ORG Undergraduates I-ORG No. O GCYS2016110001 B-AWARD and O Training B-ORG Programs I-ORG of I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG for I-ORG Undergraduates I-ORG of I-ORG of I-ORG Minzu I-ORG University I-ORG of I-ORG China I-ORG No. O MCYS2017110007 B-AWARD This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG Joint I-ORG Guide I-ORG Project I-ORG of I-ORG Heilongjiang I-ORG LH2019C035 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31872884 O and O the O “Young B-ORG Talents” I-ORG Project I-ORG of I-ORG Northeast I-ORG Agricultural I-ORG University I-ORG 17QC02 O This O work O was O supported O by O Research B-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Applied I-ORG Technology I-ORG in I-ORG Heilongjiang I-ORG Province I-ORG GA19B201 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2572018CL04 O Provincial B-ORG Funding I-ORG for I-ORG Major I-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG and I-ORG Key I-ORG R&D I-ORG Projects I-ORG in I-ORG Heilongjiang I-ORG Province I-ORG GX18B027 O and O the B-ORG 111 I-ORG Project I-ORG B16010 O The O funding O bodies O had O no O role O in O the O analysis O data O interpretation O and O manuscript O writing O This O work O was O supported O from O the O German B-ORG Federal I-ORG Ministries I-ORG of I-ORG Education I-ORG and I-ORG Research I-ORG BMBF O in O frame O of O the O zoonoses O research O consortium O PAC-Campylobacter O to O SBe O and O MMH O IP7/01KI1725D O and O to O SBa O IP9/01KI1725E O and O by O the O German B-ORG Science I-ORG Foundation I-ORG DFG O to O MMH O HE3040/3-1 O The O work O of O SW O was O supported O by O the O grant O P_31507 B-AWARD from O the O Austrian B-ORG Science I-ORG Fund I-ORG FWF O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O DL O was O supported O by O the O National B-ORG Major I-ORG Scientific I-ORG and I-ORG Technological I-ORG Special I-ORG Project I-ORG for I-ORG “Significant I-ORG New I-ORG Drugs I-ORG Development” I-ORG under O Grant O No. O 2019ZX09201004 B-AWARD ZW O was O supported O by O “Shuguang O Program” O supported O by O the O Shanghai B-ORG Education I-ORG Development I-ORG Foundation I-ORG and I-ORG Shanghai I-ORG Municipal I-ORG Education I-ORG Commission O HY O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O No. O 61902126 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 52278271 B-AWARD the O introductory B-ORG science I-ORG and I-ORG technology I-ORG plan I-ORG project I-ORG of I-ORG Fujian I-ORG province I-ORG grant O number O 2022H0028 B-AWARD and O Ningbo B-ORG major I-ORG science I-ORG and I-ORG technology I-ORG project I-ORG grant O number O 2020Z034 B-AWARD Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG BB/K012622/1 O Engineering B-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG EP/E003400/1 O EP/G03737X/1 B-AWARD Russian B-ORG Science I-ORG Foundation I-ORG 14-44-00068 O 19-14-00250 B-AWARD Funding O for O open O access O charge O Engineering O and O Physical O Sciences O Research O Council O This O work O was O supported O by O the O Associate B-ORG Laboratory I-ORG for I-ORG Green I-ORG Chemistry-LAQV I-ORG UID/QUI/50006/2019 O the O projects O PTDC/QUI-QOR/7450/2020 B-AWARD “Organic O Redox I-ORG Mediators I-ORG for I-ORG Energy I-ORG Conversion” O and O MIT-EXPL/CS/0055/2021 B-AWARD with O funding O by O Fundação B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG Tecnologia I-ORG I. I-ORG P.-FCT I-ORG This O work O is O supported O by O theMedical O Research I-ORG Council(MR/K501268/1 O theEPSRC-funded O UCL I-ORG Centre I-ORG for I-ORG Doctoral I-ORG Training I-ORG in I-ORG Medical I-ORG Imaging(EP/L016478/1 O and O theUCL O Leonard I-ORG Wolfson I-ORG Experimental I-ORG Neurology I-ORG Centre(PR/YLR/18575 O JW O is O supported O by O theWellcome O Trust/Royal I-ORG Society I-ORG Sir I-ORG Henry I-ORG Dale I-ORG Fellowship(204624/Z/16/Z O This O study O was O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O BK20150254 B-AWARD Applied B-ORG Basic I-ORG Research I-ORG of I-ORG Changzhou I-ORG Technology I-ORG Bureau I-ORG No. O CJ20140023 B-AWARD and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81502002 B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81571232,No.81371413 B-AWARD No. O 81401048 B-AWARD the O project B-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG XBR2013088 O 20154Y0004 B-AWARD and O the O project B-ORG from I-ORG the I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG 15ZR1435800 O The O research O was O carried O out O with O the O funds O of O the O Ministry B-ORG of I-ORG Education I-ORG and I-ORG Culture I-ORG of I-ORG Ukraine O grant O No. O 110/540 B-AWARD 0117U004402 I-AWARD 2017–2019 O “Biotechnological O ways O of O preserving O the O gene O pool O of O historically O valuable O centuries-old O trees” O leader—S O Bilous O grant O No. O 37 B-AWARD Basic O funding O “Agrarian O sciences I-ORG and I-ORG veterinary I-ORG medicine” O 2021 O leader—A O Likhanov O and O grant O No. O 110/14-pr-2022 B-AWARD “Innovative O solutions I-ORG for I-ORG measuring I-ORG the I-ORG quality I-ORG of I-ORG hardwood I-ORG wood I-ORG for I-ORG forecasting I-ORG and I-ORG organizing I-ORG the I-ORG integrated I-ORG use I-ORG of I-ORG forest I-ORG resources” O leader—R O Vasylyshyn O co-leader—A O Likhanov O co-inventor—S O Bilous O SXG O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O grant O No. O 11671129 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG 2015JJ1010 O CPL O is O supported O in O part O by O funding B-ORG from I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 104-2218-E-010-007-MY3 O MOST O 105-B-2633-400-001 O and O MOST O 106-2321-B-010-011 O and O National B-ORG Health I-ORG Research I-ORG Institutes I-ORG NHRI-EX106-10611EI O and O Taipei O Veterans O General O Hospital O Taiwan O grants O VGHUST102-G1-2-1 O and O VGHUST103-G1 O 4-1 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 71603131),https://isisn.nsfc.gov.cn/egrantweb O Jiangsu B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG BK20161030),http://210.73.128.81/13kjskj2 O Top-notch B-ORG Academic I-ORG Programs I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG TAPP I-ORG PPZY2015A067),http://180.209.64.40 O This O research O was O funded O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.91951108 O and O No. O 42177099 B-AWARD the B-ORG Key I-ORG R&D I-ORG plan I-ORG of I-ORG Ningxia I-ORG Hui I-ORG Autonomous I-ORG Region I-ORG 2019BFG02032 O and O the B-ORG CAS I-ORG International I-ORG Partnership I-ORG Program I-ORG No.121311KYSB20200017 O and O Open B-ORG Project I-ORG of I-ORG Key I-ORG Laboratory I-ORG of I-ORG Environmental I-ORG Biotechnology I-ORG CAS I-ORG Grant O No. O kf2020003 B-AWARD We O acknowledge O the O financial O support O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG Project O Nos O F2017202052 B-AWARD F2017202026 B-AWARD and O F2018202080 B-AWARD Program B-ORG for I-ORG Top I-ORG 100 I-ORG Innovative I-ORG Talents I-ORG in I-ORG Colleges I-ORG and I-ORG Universities I-ORG of I-ORG Hebei I-ORG Province I-ORG Project O No. O SLRC2017032 B-AWARD Program B-ORG for I-ORG 100-Talent-Plan I-ORG of I-ORG Hebei I-ORG Province I-ORG Project O No. O E2016100010 B-AWARD and O Suzhou B-ORG Institute I-ORG of I-ORG Nano-Tech I-ORG and I-ORG Nano-Bionics I-ORG SINANO I-ORG Research I-ORG Fund I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Science I-ORG Project O No. O 19ZS02 B-AWARD This O study O was O supported O by O Max-Planck-Gesellschaft B-ORG Max O Planck I-AWARD Group I-AWARD Leader I-AWARD grant O Deutscher B-ORG Akademischer I-ORG Austauschdienst I-ORG grant O no. O 57381410 B-AWARD and O Deutsche B-ORG Forschungsgemeinschaft I-ORG grant O no. O MI B-AWARD 2109/1-1 O This O work O was O supported O by O FONDAP B-ORG Grant O 15090007 B-AWARD of O the O Center O for O Genome O Regulation O CGR O Apoyo B-ORG a I-ORG la I-ORG Formación I-ORG de I-ORG Redes I-ORG Internacionales I-ORG para I-ORG Investigadores I-ORG REDI170193 B-AWARD and O FONDECYT B-ORG Grant O N° O 11150679 B-AWARD to O Mauricio O Latorre O CONICYT B-ORG Basal I-ORG Grant I-ORG PFB I-ORG 03 I-ORG of O the O Center B-AWARD for I-AWARD Mathematical I-AWARD Modeling I-AWARD CMM I-AWARD UMI2807 I-AWARD UCHILE-CNRS O to O Servet O Martinez O and O Mauricio O Latorre O All O the O authors O also O acknowledge O the O support O of O the O National B-AWARD Laboratory I-AWARD of I-AWARD High I-AWARD Performance I-AWARD Computing I-AWARD NLHPC O at O the O CMM O PIA O ECM-02.-CONICYT O This O work O was O supported O by O the O National B-ORG Programs I-ORG for I-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG 863 O Project O 2012AA10A305 B-AWARD the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG the O “973” O project O 2009CB118404 B-AWARD and O the O Chinese B-ORG 111 I-ORG Project I-ORG B07041 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O National B-ORG Program I-ORG on I-ORG Key I-ORG Basic I-ORG Research I-ORG Project O 973 O Program O 2014CB910504 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61473106 O 31501038 B-AWARD 31601080 B-AWARD 61741306 B-AWARD 61803129 B-AWARD Harbin O Special O Funds O for O Innovative B-ORG Talents I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Project O 2016RAQXJ191 O 2017RAGXJ004 B-AWARD Yu O Weihan O Outstanding O Youth O Training O Fund O of O Harbin B-ORG Medical I-ORG University O and O the O University O Nursing O Program O for O Young O Scholars O with O Creative O Talents O in O Heilongjiang O Province O UNPYSCT-2017071 O Funding O for O open O access O charge O National O Program O on O Key O Basic O Research O Project O 973 O Program O 2014CB910504 O National O Natural O Science O Foundation O of O China O 61473106 O 31501038 O 31601080 O 61741306 O 61803129 O This O work O was O financially O supported O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0900304 O China B-ORG Agriculture I-ORG Research I-ORG System O grant O number O CARS-49 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31602142 O and O 31502208 B-AWARD This O study O was O supported O by O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Fujian I-ORG Province I-ORG no. O 2018N5002 B-AWARD Forestry B-ORG Science I-ORG Research I-ORG Project I-ORG of I-ORG Fujian I-ORG Forestry I-ORG Department I-ORG no. O Minlinke B-AWARD 2017 I-AWARD 03 O Major B-ORG Scientific I-ORG and I-ORG Technological I-ORG Special I-ORG Project I-ORG of I-ORG Fujian I-ORG Province I-ORG no. O 2017NZ0003-1-6 B-AWARD This O work O is O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. B-AWARD 11975122 I-AWARD and O Grant O No. B-AWARD 21906083 O and O Jiangsu B-ORG Province I-ORG Science I-ORG Foundation I-ORG for O Youths O Grant O No. B-AWARD BK20190384 O This O research O was O funded O by O the O National B-ORG Cancer I-ORG Institute I-ORG of O the O National O Institutes O of O Health O Grant O RO1CA045424 B-AWARD and O by O the O National B-ORG Science I-ORG Foundation I-ORG under O Grant O No. O CHE-1920110 B-AWARD to O AA. O In O addition O A.A O thanks O R.E.F O and O C.B.R O at O Oakland O University O for O support O The O authors O are O also O grateful O to O David O Becker O Anil O Kumar O and O Michael O D. O Sevilla O Department O of O Chemistry O Oakland O University O for O their O comments O and O critical O reading O of O our O manuscript O This O work O is O supported O by O the O National B-ORG Key I-ORG R. I-ORG and I-ORG D. I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFB0309903 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51508030 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG China I-ORG Nos O 300102318402 I-AWARD 300102219509 I-AWARD and I-AWARD 300102319501 O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31402006 O and O the O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O LY17C040001 I-AWARD No. I-AWARD LGN18C190007 O In O addition O this O work O was O supported O by O Taizhou B-ORG science I-ORG and I-ORG technology I-ORG project I-ORG Grant O No. O 1901ny09 B-AWARD There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Swedish B-ORG Research I-ORG Council I-ORG for I-ORG Medicine I-ORG VR; O 521-2013-8676 B-AWARD 2017-06088 B-AWARD 2016-00981 B-AWARD the O Swedish B-ORG Research I-ORG Council I-ORG for I-ORG Health I-ORG Working I-ORG life I-ORG and I-ORG Welfare I-ORG Forte O 2016-07175 B-AWARD 2017-01764 B-AWARD Loo B-ORG and I-ORG Hans I-ORG Osterman I-ORG Foundation I-ORG 2020-01232 O Gamla O Tjänarinnor O 2020-01058 O The O funder O of O the O study O had O no O role O in O study O design O data O collection O data O analysis O data O interpretation O or O writing O of O the O report O The O corresponding O author O had O full O access O to O all O the O data O in O the O study O and O had O final O responsibility O for O the O decision O of O submission O This O work O was O supported O by O the O Young B-ORG Doctor I-ORG Fund I-ORG Project I-ORG of I-ORG the I-ORG Gansu I-ORG Province I-ORG Education I-ORG Department I-ORG under O Grant O No. O 2021QB-064 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O No. O 32260037 B-AWARD and O Gansu B-ORG Youth I-ORG Science I-ORG and I-ORG Technology I-ORG Fund I-ORG Project I-ORG under O Grant O No. O 22JR5RA193 B-AWARD and O 20JR5RA501 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O numbers I-AWARD 81870033 I-AWARD 81302016 I-AWARD 81302015 O the B-ORG Six I-ORG Talent I-ORG Peaks I-ORG Poject I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grant O number I-AWARD WSN-106 O the B-ORG Medical I-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG of I-ORG China I-ORG Grant O numbers I-AWARD QNRC2016340 O the B-ORG Foundation I-ORG for I-ORG High-level I-ORG Talents I-ORG during I-ORG the I-ORG 13th I-ORG Five-year I-ORG Plan I-ORG Period I-ORG of I-ORG Yangzhou I-ORG China I-ORG Grant O numbers I-AWARD ZDRC201866 O This O work O was O supported O by O funds O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 32001961 B-AWARD 32160666 B-AWARD and O the O Guizhou B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Project I-ORG [2022 O General B-AWARD 239 O to O W.Z O and O the O Natural O Science O Foundation O of O China O No. O 32172469 B-AWARD and O the O Program B-ORG of I-ORG Introducing I-ORG Talents I-ORG to I-ORG Chinese I-ORG Universities I-ORG 111 O Program O D20023 B-AWARD to O L-S.Z O This O project O has O received O funding O from O the O European B-ORG Union’s I-ORG Horizon I-ORG 2020 I-ORG research I-ORG and I-ORG innovation I-ORG programme I-ORG under I-ORG the I-ORG Marie I-ORG Skłodowska-Curie I-ORG grant O agreement O No O 860329 B-AWARD Author O V.J O is O funded O by O the O ‘Deutsche O Forschunggemeinschaft’ O DFG O German O Research O Foundation O through O the O Transregional B-ORG Collaborative I-ORG Research I-ORG Centre I-ORG TRR O 219 O Project-ID O 322900939 B-AWARD subproject O S-03 O INST O 948/4S-1 O CRU O 5011 O project O number O 445703531 B-AWARD Authors O H.M O G.G O A.V O and O V.J O are O funded O by O the O Cost-Action B-ORG CA I-ORG 21165 I-ORG IZKF I-ORG Multiorgan I-ORG complexity I-ORG in I-ORG Friedreich I-ORG Ataxia O CA201165 B-AWARD This O work O was O supported O by O grants O from O the O Basic B-ORG Public I-ORG Welfare I-ORG Research I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG no. O LGF21H160027 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Agency I-ORG of I-ORG the I-ORG City I-ORG of I-ORG Taizhou I-ORG no. O 20ywa09 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Agency I-ORG of I-ORG Taizhou I-ORG City I-ORG no. O 1902ky06 B-AWARD China O This O work O was O financially O supported O by O the O projects O from O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0101300 O the B-ORG National I-ORG Transgenic I-ORG Research I-ORG Projects I-ORG of I-ORG China I-ORG 2018ZX08020001-011 O and O the O Key B-ORG R&D I-ORG Program I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 2018NY-055 O The O funding O body O played O no O role O in O the O design O of O the O study O the O collection O analysis O and O interpretation O of O data O and O the O writing O of O the O manuscript O We O acknowledge O the O financial O support O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 12075145 O 11474193 O STCSM B-ORG 2019SHZDZX01-ZX04 O 18010500400 I-AWARD and I-AWARD 18ZR1415500 O Program O for O Eastern O Scholar O HiQ O funding O for O developing O STA O YBN2019115204 O QMiCS O 820505 O and O OpenSuperQ O 820363 O of O the O EU O Flagship O on O Quantum O Technologies O Spanish O Government O PGC2018-095113-B-I00 O MCIU/AEI/FEDER O UE O Basque B-ORG Government I-ORG IT986-16 B-AWARD EU O FET O Open O Grant O Quromorphic O 828826 O as O well O as O EPIQUS O 899368 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81471725 B-AWARD the O Key B-ORG Technologies I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG grant O number O 2016YFC1300402 B-AWARD and O Peking B-ORG Union I-ORG Medical I-ORG College I-ORG grant O number O 2017-1002-02-18 B-AWARD The O funding O bodies O had O no O role O in O the O design O of O the O study O the O collection O analysis O and O interpretation O of O the O data O or O the O writing O of O the O manuscript O This O work O was O financially O supported O by O The O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2016YFD0102100 B-AWARD Grant O No. O 2016YFD0101802 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31801346 B-AWARD and O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG Grant O No. O CARS-03 B-AWARD These O funding O bodies O had O no O roles O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O partially O funded O by O the O European B-ORG Space I-ORG Agency I-ORG ESA O Contract O No. O 4000137290 B-AWARD the O Spanish B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Innovation I-ORG projects O PID2019-105717RB-C22 B-AWARD RODIN O and O PID2021-122842OB-C21 B-AWARD the O ERDF O a O way O of O making O Europe O by O the O European O Union O the O Institute B-ORG of I-ORG Cosmos I-ORG Sciences I-ORG University I-ORG of I-ORG Barcelona I-ORG ICCUB O Unidad O de O Excelencia O María O de O Maeztu O through O grant O CEX2019-000918-M B-AWARD grant O 2021 O SGR O 1033 O by O Generalitat O de O Catalunya O AGAUR O and O fellowship O FPI-UPC O 2022 O by O Universitat O Politècnica O de O Catalunya O and O Banc O de O Santander O This O material O is O based O upon O work O supported O by O the O U.S B-ORG Department I-ORG of I-ORG Homeland I-ORG Security I-ORG task O order O HSHQDC-16-J-00459 B-AWARD SAH O ACM O The O views O and O conclusions O contained O in O this O document O are O those O of O the O authors O and O should O not O be O interpreted O as O necessarily O representing O the O official O policies O either O expressed O or O implied O of O the O U.S O Department O of O Homeland O Security O Additional O support O was O from O the O National B-ORG Science I-ORG Foundation I-ORG Graduate O Research O Fellowship O Program O under O Grant O No. O 1746932 B-AWARD ACM O National B-ORG Institutes I-ORG of I-ORG Health I-ORG Grant O No. O 5T35OD010991 B-AWARD MME O JCP O and O the O Boehringer B-ORG Ingelheim I-ORG Veterinary B-AWARD Scholars I-AWARD Program I-AWARD MME O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51804330 O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No. O 18CX02154A B-AWARD Major B-ORG Project I-ORG of I-ORG the I-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG Grant O No. O 2016ZX05017-003 B-AWARD and O the O Key O Laboratory O Project O of O China O National O Petroleum O Corporation O Grant O No. O 2016A-3905 B-AWARD This O research O was O funded O by O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDA19050102 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41530102 O Key B-ORG Research I-ORG Program I-ORG of I-ORG Frontier I-ORG Sciences I-ORG of I-ORG CAS I-ORG QYZDJ-SSW-DQC002 O and O CAS O Funds O for O Paleontology O Fieldwork O and O Fossil O Preparation O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O has O been O supported O by O the O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 I-ORG program I-ORG 2015CB554501 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81503656 O the O Shanghai B-ORG Sailing I-ORG Program I-ORG 15YF1411200 O and O the O Shanghai B-ORG Municipal I-ORG Health I-ORG Bureau I-ORG 20154Y0138 O This O study O was O funded O by O the O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health I-ORG NIMH O R01MH111391 B-AWARD the O Center B-ORG for I-ORG HIV I-ORG Identification I-ORG Prevention I-ORG and I-ORG Treatment I-ORG Services I-ORG CHIPTS O P30MH058107 B-AWARD the O UCLA B-ORG Center I-ORG for I-ORG AIDS I-ORG Research I-ORG CFAR O P30AI028697 B-AWARD the O National B-ORG Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences I-ORG through I-ORG UCLA I-ORG Clinical I-ORG and I-ORG Translational I-ORG Science I-ORG Institute I-ORG CTSI O UL1TR001881 B-AWARD and O the O Postdoctoral B-ORG HIV I-ORG Research I-ORG Training I-ORG Program I-ORG for I-ORG HIV I-ORG Combination I-ORG Prevention I-ORG T32 O T32MH109205 B-AWARD MT O is O supported O by O the O National O Research O Foundation O South O Africa O and O is O a O Lead O Investigator O of O the O Centre O of O Excellence O in O Human O Development O University O Witwatersrand O South O Africa O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFA0105501 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81425016 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG S2013030013305 O 2015A030312013 B-AWARD and O 2017A030310237 B-AWARD the O Key B-ORG Scientific I-ORG and I-ORG Technological I-ORG Projects I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2014B020226002 O 2015B020226004 B-AWARD and O 2014B020228003 B-AWARD the O Key B-ORG Scientific I-ORG and I-ORG Technological I-ORG Program I-ORG of I-ORG Guangzhou I-ORG City I-ORG 201400000003-3 O 201508020262 B-AWARD the O Guangdong B-ORG Province I-ORG Universities I-ORG and I-ORG Colleges I-ORG Pearl I-ORG River I-ORG Scholar I-ORG Funded I-ORG Scheme I-ORG GDUPS O 2013 O the O Key O Scientific O and O Technological O Projects O of O Guangdong O Province O 2014B020225007 O 2017B020231001 B-AWARD the O Key O Scientific O and O Technological O Projects O of O Guangdong O Province O 2014B020212009 O the O Key O Scientific O and O Technological O Program O of O Guangzhou O City O 201508020254 O and O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2016M602583 O 2017T100657 B-AWARD This O study O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31730015 B-AWARD the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDB31000000 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2572017EA02 O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0900400 O to O Z.S.S O Funding O for O open O access O charge O National O Key O R&D O Program O of O China O 2016YFC0900400 O to O Z.S.S O Beijing O Municipal O Commission O of O Health O and O Family O Planning O Project O PXM2018_026279_000005 O to O Q.M.Z O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81490753 O 81502150 B-AWARD to O Q.M.Z O National B-ORG 973 I-ORG Program I-ORG 2015CB553904 O to O Q.M.Z O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M641117 O to O X.F.L O This O work O was O supported O by O the B-ORG Joint I-ORG Construction I-ORG by I-ORG Provinces I-ORG and I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG SB201901083 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31671440 O 81773132 O and O the B-ORG Key I-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Project I-ORG of I-ORG Henan I-ORG Province I-ORG 212102310151 O This O research O was O funded O by O the O Key O Projects O of O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG of I-ORG China I-ORG 2017YFD0101803 O the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-23-A-06 O the O National O Key O Research O and O Development O Plan O of O China O 2016YFD0101701 O the O Natural O Science O Youth O Foundation O of O Jiangsu O province O BK20190513 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG province I-ORG BK20170462 O The O funding O is O mainly O used O for O the O purchase O of O reagents O and O consumables O used O in O this O experiment O and O biologic O sequencing O etc O This O project O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O number O 31702298 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grant O number O BK20170498 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O number O 2017M621843 B-AWARD the O Postgraduate B-ORG Research I-ORG and I-ORG Practice I-ORG Innovation I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grant O number O SJCX21_1643 B-AWARD and O SJCX21_1639 B-AWARD the O United B-ORG States I-ORG National I-ORG Institute I-ORG of I-ORG Environmental I-ORG Health I-ORG Sciences I-ORG Grant O number O R01ES024681 B-AWARD and O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH O Grant O number O 5R01ES024681-12 B-AWARD This O project O was O sponsored O by O the O Qing O Lan O Project O of O Yangzhou O University O Fenglei O Chen O the O High O Talent O Supporting O Program O of O Yangzhou O University O Fenglei O Chen O the O Priority O Academic O Program O Development O of O Jiangsu O Higher O Education O Institution O PAPD O and O the O 111 O Project O D18007 O The O APC O was O funded O by O the O National O Natural O Science O Foundation O of O China O Grant O number O 31702298 O The O PROTECT O study O was O funded O by O an O Economic B-ORG and I-ORG Social I-ORG Research I-ORG Council I-ORG ESRC O grant O awarded O to O SLH O ref O ES/K006290/1 B-AWARD RMS O was O funded O by O a O Medical B-ORG Research I-ORG Council I-ORG Clinician I-ORG Scientist I-ORG Fellowship I-ORG and I-ORG Centenary I-ORG Award O ref O G0802821 B-AWARD CC O was O funded O by O an O NIHR B-ORG Research I-ORG Professorship I-ORG RP_2014-04-018 O The O PYCES O study O was O funded O by O the O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG NIHR O under O its O Research O for O Patient O Benefit O RfPB O Programme O awarded O to O TD O ref O PB-PG-0211-24045 B-AWARD The O views O expressed O are O those O of O the O authors O and O not O necessarily O those O of O the O National O Health O Service O the O NIHR O or O the O Department O of O Health O Please O contact O the O corresponding O author O with O any O queries O relating O to O data O access O This O work O was O supported O by O the O Foundation B-ORG of I-ORG the I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG Shanghai I-ORG No. O 201840166 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Province I-ORG No. O 20202ACB206006 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 82260587 B-AWARD This O study O was O funded O by O the O Key B-ORG Laboratory I-ORG of I-ORG Diagnosis I-ORG and I-ORG Treatment I-ORG of I-ORG Digestive I-ORG System I-ORG Tumors I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. O 2019E10020 B-AWARD Ningbo B-ORG Clinical I-ORG Research I-ORG Center I-ORG for I-ORG Digestive I-ORG System I-ORG Tumors I-ORG No. O 2019A21003 B-AWARD and O Oncology B-ORG Key I-ORG Special I-ORG Subject I-ORG of I-ORG Ningbo I-ORG 2016-55 O This O study O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81572078 B-AWARD 81401722 B-AWARD 81873982 B-AWARD 81860723 B-AWARD 8187081672 B-AWARD and O 8186140341 B-AWARD The B-ORG Projects I-ORG of I-ORG Basic I-ORG Research I-ORG and I-ORG Frontier I-ORG Exploration I-ORG in I-ORG Chongqing I-ORG No. O cstc2019jcyj-zdxm0037 B-AWARD The B-ORG Third I-ORG Military I-ORG Medical I-ORG University I-ORG Medical I-ORG Creative I-ORG Research I-ORG Foundation I-ORG No. O SWH2016JCYB-62 B-AWARD and O SWH2016JCYB-33 B-AWARD Traditional B-ORG Chinese I-ORG Medicine I-ORG National I-ORG Medicine I-ORG Science I-ORG and I-ORG Technology I-ORG Fund I-ORG No. O QZYY-2018-019 B-AWARD Army B-ORG Innovation I-ORG Research I-ORG Project I-ORG No. O LJ20182B060005 B-AWARD Project O Funded O by O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2018M643862 B-AWARD Department O of O Science O and O Technology O of O Guizhou O Province O Science O and O Technology O Program O No. O Qian O Scientific O Cooperation O LH O 2013]2047 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0101001 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 91935302 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2662018JC030 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81270630 O Medical B-ORG Innovation I-ORG Team I-ORG of I-ORG Jiangsu I-ORG Province I-ORG CXTDB2017002 O 333 B-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BRA2016131 O Six B-ORG Talent I-ORG Peaks I-ORG Project I-ORG in I-ORG Jiangsu I-ORG Province I-ORG 2015-WSN-115 O Postgraduate B-ORG Research I-ORG I-ORG Practice I-ORG Innovation I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG KYCX17_1821 O KYCX18_2281 O Key O Medical O Talent O Program O of O Zhenjiang O City O This O work O was O supported O by O grants O from O the O Key B-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC)-Henan I-ORG United I-ORG Fund I-ORG No. O U1704232 O Key B-ORG Scientific I-ORG and I-ORG Technological I-ORG Project I-ORG of I-ORG Henan I-ORG Province I-ORG No. O 161100111000 O S2012–05-G03 B-AWARD Innovation B-ORG Scientists I-ORG and I-ORG Technicians I-ORG Troop I-ORG Construction I-ORG Projects I-ORG of I-ORG Henan I-ORG Province I-ORG No. O 2018JR0001 O These O funding O bodies O have O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O supported O in O part O by O several O grants O The O collection O of O material O was O done O with O support O from O the O Russian B-ORG Foundation I-ORG for I-ORG Basic I-ORG Research I-ORG #14-04-00238 O The O TEM O studies O were O conducted O with O support O from O the O Russian O Foundation O for O Basic O Research O #15-04-20045 O O 15-29-02601 B-AWARD Cytochemical O investigations O were O done O with O support O from O the O Russian B-ORG Science I-ORG Foundation I-ORG #14-04-00262 O detailed O 3D O reconstructions O were O done O with O support O from O the O Russian O Science O Foundation O #14-50-00029 O and O the O processing O of O the O paper O was O supported O by O Grants B-ORG of I-ORG the I-ORG President I-ORG of I-ORG Russia I-ORG # O MD-5812.2015.4 B-AWARD The O work O was O performed O at O the O User O Facilities O Center O of O M.V O Lomonosov O Moscow O State O University O under O financial O support O of O the O Ministry O of O Education O and O Science O of O Russian O Federation O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81803375 B-AWARD the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG No. O ASTIP-TRIC05 B-AWARD the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shandong I-ORG Province O No. O 2019GSF107091 B-AWARD the O Fundamental O Research O Funds O for O the O Central O Non-Profit O Scientific O Institution O No. O 1610232019006 O the O National O Postdoctoral O Program O for O Innovative O Talents O No. O BX201700247 O and O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2018M630804 B-AWARD This O study O was O financially O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81670957 O 81402235 B-AWARD 81772876 B-AWARD 81700938 B-AWARD the O seed O grants O from O the O PKU B-ORG School I-ORG of I-ORG Stomatology I-ORG for I-ORG PostDoc I-ORG YS0203 O the O grant O of O Peking B-ORG University I-ORG School I-ORG and I-ORG Hospital I-ORG of I-ORG Stomatology I-ORG PKUSS20140104 O and O the O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 7172239 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O is O funded O by O the O National B-ORG Key I-ORG Specialty I-ORG Construction I-ORG Project I-ORG of I-ORG Clinical I-ORG Pharmacy I-ORG 30305030698 O the O Youth B-ORG Scientists’ I-ORG Fund I-ORG of I-ORG Sichuan I-ORG Provincial I-ORG People’s I-ORG Hospital I-ORG 2017QN11 O and I-AWARD 2017QN15 O the O Sichuan B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Basic I-ORG Scientific I-ORG Research I-ORG Funds I-ORG 30504010425 O the O Sichuan B-ORG Provincial I-ORG Cadre I-ORG Health I-ORG Research I-ORG Project I-ORG Grant O No. O 2018-211 B-AWARD the O Opening B-ORG Project I-ORG of I-ORG Personalized I-ORG Drug I-ORG Therapy I-ORG Key I-ORG Laboratory I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2018YB06 O the O Sichuan B-ORG Provincial I-ORG Health I-ORG Research I-ORG Project I-ORG Popularization I-ORG Project I-ORG 19PJ163 B-AWARD and O the O Chengdu B-ORG Medical I-ORG Research I-ORG Project I-ORG 2019067 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 82041010 B-AWARD Shanghai B-ORG Association I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG grant O number O 20411950400 B-AWARD Shanghai B-ORG Youth I-ORG Science I-ORG and I-ORG Technology I-ORG Talents I-ORG Sailing I-ORG Project I-ORG grant O number O 20YF1404300 B-AWARD and O the O Investigator B-ORG Initiated I-ORG Study I-ORG grants I-ORG grant O number O Cepheid-IIS-2020-0001 B-AWARD to O WHZ O This O study O was O supported O by O the O Key B-ORG Projects I-ORG of I-ORG the I-ORG Joint I-ORG Fund I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U1802232 O the O Second B-ORG Tibetan I-ORG Plateau I-ORG Scientific I-ORG Expedition I-ORG and I-ORG Research I-ORG STEP I-ORG program I-ORG 2019QZKK0502 O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0505200 O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDA20050203 O the O Major O Program O of O the O National O Natural O Science O Foundation O of O China O 31590823 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O MOE B-ORG Ministry O of O Education O in O China O Project O of O Humanities O and O Social O Sciences O and O the O Soft O science O research O project O of O Science O No. O 18YJCZH029 B-AWARD The O authors O would O also O like O to O acknowledge O financial O support O from O the O youth O talent O project O of O Wuhan-Shuguang B-ORG project I-ORG No. O 2022010801020365 B-AWARD the O Research O Fund O Project O of O Wuhan B-ORG Institute I-ORG of I-ORG Technology I-ORG No. O K202248 B-AWARD the O Statistical O Research O Project O of O National B-ORG Bureau I-ORG of I-ORG Statistics I-ORG in I-ORG China I-ORG No. O 2022LY057 B-AWARD and O Social B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG No. O HBSK2022YB336 B-AWARD HBSK2022YB339 B-AWARD The O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81803035 O 81572946 I-AWARD 81703036 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG China I-ORG 2019JJ50932 O and O the O Youth B-ORG Fund I-ORG of I-ORG Xiangya I-ORG Hospital I-ORG 2017Q17 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFF0201801 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 41573066 B-AWARD the O Foundation B-ORG for I-ORG Safety I-ORG of I-ORG Agricultural I-ORG Products I-ORG by I-ORG the I-ORG Ministry I-ORG of I-ORG Agriculture I-ORG China I-ORG GJFP201801202 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Non-profit I-ORG Scientific I-ORG Institution I-ORG No. O 1610132017010 B-AWARD This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81761128030 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG Grant O No. O 2018A0303130331 B-AWARD the O Science B-ORG Foundation I-ORG for I-ORG the I-ORG Youth I-ORG Scholars I-ORG of I-ORG Sun I-ORG Yat-sen I-ORG University I-ORG Grant O No. O 18ykpy15 B-AWARD and O the O Guangdong O Food O and O Drug O Administration O Grant O No. O GZCY2014FT11023 B-AWARD The O sponsors O had O no O role O in O the O design O and O conduct O of O the O study O collection O management O analysis O and O interpretation O of O the O data O preparation O review O or O approval O of O the O manuscript O or O decision O to O submit O the O manuscript O for O publication O This O research O was O funded O by O the O Spanish B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Innovation I-ORG Research O Project O BFU-2010-21451 B-AWARD Xunta B-ORG de I-ORG Galicia I-ORG Research O Project O ROCLIGAL O 10MDS291009PR B-AWARD and O Agencia B-ORG Estatal I-ORG de I-ORG Investigación I-ORG Research O Project O THERMOXYLO O PID2019-108304GB-I00 B-AWARD The O authors O are O also O grateful O to O Xunta O de O Galicia O Consellería O de O Educación O Universidade O e O Formación O Profesional O for O the O financial O support O provided O by O the O recognition O as O a O Research B-ORG Competitive I-ORG Reference I-ORG Group I-ORG GRC O GI-1809 I-AWARD BIOAPLIC O ED431C B-AWARD 2019/07 O This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China O grant O number O 2017YFC0404902 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 51479048 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities O grant O number O 2018B657X14 B-AWARD and O the O Postgraduate O Research O O Practice O Innovation O Program O of O Jiangsu O Province O grant O number O KYCX18_0557 O and O the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Water I-ORG Conservancy I-ORG Department O grant O number O RA1503 B-AWARD The O authors O gratefully O acknowledge O the O financial O supports O This O study O was O supported O by O a O Cleveland O Clinic O Center O for O Translational O Science O Activities O CTSA O American B-ORG Diabetes I-ORG Association I-ORG ADA O grant O 1-15IN-31 B-AWARD National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH O Grants O RO1GM112044 B-AWARD and O 1R01HL129120 O and O American B-ORG Heart I-ORG Association I-ORG AHA O grant O 15GRNT25500004 B-AWARD This O work O was O supported O by O Faculty B-ORG of I-ORG Allied I-ORG Health I-ORG Sciences I-ORG Research I-ORG Fund I-ORG AHS_CU O 59009 O Chulalongkorn O University O 90th B-ORG Anniversary I-ORG Chulalongkorn I-ORG University I-ORG Fund I-ORG Ratchadaphiseksomphot I-ORG Endowment I-ORG Fund O GCUGR1125601059M B-AWARD no. I-AWARD 54 O and O Japan B-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG KAKENHI I-ORG YK, O JP17K08976 O Funds O have O been O used O for O experimentation O All O funding O bodies O did O not O participate O in O the O design O of O the O study O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O supported O by O the O European B-ORG Commission I-ORG under I-ORG the I-ORG framework I-ORG programme I-ORG of I-ORG the I-ORG European I-ORG Union I-ORG grant O agreement O No. O 211696 B-AWARD EU B-ORG Joint I-ORG Programme—Neurodegenerative I-ORG Disease I-ORG Research I-ORG JPND I-ORG and I-ORG BMBF I-ORG grants I-ORG MIND-AD I-ORG 01ED1509 O and O EURO-FINGERS B-ORG 01ED2003 O This O work O was O supported O by O NCI O Grant O Numbers O P01CA196569 B-AWARD and O P30CA014089 B-AWARD and O NIEHS B-ORG Grant O Number O P30ES07048 B-AWARD The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O National B-ORG Institutes I-ORG of I-ORG Health O The O funding O body O NIH B-ORG did O not O play O any O role O in O the O design O of O the O study O the O collection O analysis O and O interpretation O of O data O or O in O writing O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31100938 O and O 31470114 B-AWARD Young B-ORG Elite I-ORG Scientist I-ORG Sponsorship I-ORG Program I-ORG by I-ORG China I-ORG Association I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG YESS O 20150026 O and O Henan B-ORG Basic I-ORG and I-ORG Frontier I-ORG Technology I-ORG Research I-ORG Program I-ORG 162300410133 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O grant O 31500514 B-AWARD Forestry B-ORG Technology I-ORG Innovation I-ORG and I-ORG Promotion I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG LYKJ O 2022]18 O and O the O Special B-ORG Fund I-ORG of I-ORG the I-ORG Chestnut I-ORG Germplasm I-ORG Resources I-ORG Repositories I-ORG in I-ORG Jiangsu I-ORG Province I-ORG SLBZ O 2018]4 O This O study O was O funded O by O the O Hunan B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 2017NK2221 O the O National B-ORG Public I-ORG Welfare I-ORG Forestry I-ORG Project I-ORG 200904011 O the O Science B-ORG Research I-ORG and I-ORG Technology I-ORG Development I-ORG Project I-ORG of I-ORG Guangxi I-ORG 1598025-42 O and O the O Open B-ORG Project I-ORG for I-ORG Guangxi I-ORG Key I-ORG Laboratory I-ORG of I-ORG Superior I-ORG Timber I-ORG Trees I-ORG Resource I-ORG Cultivation I-ORG 15-B-03-01 O The O Schornack O group O is O funded O by O the O Gatsby B-ORG Charitable I-ORG Foundation I-ORG RG62472 O the O Royal B-ORG Society I-ORG RG69135 O the O BBSRC O OpenPlant O initiative O BB/L014130/1 O and O the O Natural B-ORG Environment I-ORG Research I-ORG Council I-ORG NERC O NE/N00941X/1 B-AWARD This O paper O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 71862026,http://www.nsfc.gov.cn O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018T110209,http://jj.chinapostdoctor.org.cn O Inner B-ORG Mongolia I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 2018MS07006,http://www.nmkjt.gov.cn O and O State B-ORG Scholarship I-ORG Found I-ORG of I-ORG China I-ORG Scholarship I-ORG Council I-ORG 201808155025,https://www.csc.edu.cn O Jianwei O Ren O received O these O awards O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Inner O Mongolia O Branch O of O Agricultural O Bank O of O China O provided O support O in O the O form O of O salaries O for O Chunhua O Chen O but O did O not O have O any O additional O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O specific O roles O of O these O authors O are O articulated O in O the O ‘author O contributions’ O section O This O study O was O financially O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31501981 O and I-AWARD 31430081 O Modern B-ORG Agro-Industry I-ORG Technology I-ORG Research I-ORG System I-ORG CARS-37 O and O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG ASTIP-IAS12 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O a O Medical B-ORG Research I-ORG Council I-ORG Centre O grant O G0601943 O and O a O European O Community’s O Seventh B-ORG Framework I-ORG Programme I-ORG FP7/2007–2013 O under O grant O agreement O n° O 2012-305121 B-AWARD “Integrated O European O –omics O research O project O for O diagnosis O and O therapy O in O rare O neuromuscular O and O neurodegenerative O diseases O NEUROMICS)” O Part O of O this O work O was O undertaken O in O the O University O College O London O Hospitals/University O College O London O Queen O Square O Institute O of O Neurology O sequencing O facility O which O received O a O proportion O of O funding O from O the O Department O of O Health’s O National O Institute O for O Health O Research O Biomedical O Research O Centres O funding O scheme O The O clinical O and O diagnostic O “Rare O Mitochondrial O Disorders” O Service O in O London O is O funded O by O the O UK O NHS O Highly O Specialised O Commissioners O R.D.S.P O is O supported O by O a O Medical O Research O Council O Clinician O Scientist O Fellowship O MR/S002065/1 O O.V.P O has O received O funding O from O the O Lily O Foundation O J.A.M O was O supported O by O the O E-Rare B-ORG project I-ORG GENOMIT I-ORG FWF B-AWARD I I-AWARD 2741-B26 I-AWARD This O work O was O supported O by O the O Sci-Tech O Talents O Projects O of O Xinjiang B-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences(xjnkq-2022010 O Project O of O Fund O for O Stable B-ORG Support I-ORG to I-ORG Agricultural I-ORG Sci-Tech I-ORG Renovation I-ORG xjnkywdzc-2022001-3 O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-15-09 O Xinjiang B-ORG Youth I-ORG Science I-ORG Fund I-ORG General I-ORG Program I-ORG 2022D01A259 O This O work O was O supported O in O part O by O the B-ORG Project I-ORG for I-ORG Youth I-ORG Scholars I-ORG of I-ORG Higher I-ORG Education I-ORG of I-ORG Hebei I-ORG Province I-ORG QN2017402 O the B-ORG Project I-ORG of I-ORG Teaching I-ORG Research I-ORG and I-ORG Practice I-ORG of I-ORG Higher I-ORG Education I-ORG of I-ORG Hebei I-ORG Province I-ORG 2017GjjG364 O and O the B-ORG Project I-ORG of I-ORG Teaching I-ORG and I-ORG Research I-ORG of I-ORG Beijing I-ORG Jiaotong I-ORG University I-ORG Haibin I-ORG College I-ORG HBJY16005 O The O role O the O Project O of O Foundation B-ORG for I-ORG Fundamental I-ORG Research I-ORG of I-ORG China I-ORG JSZL2016110B003 O is O designing O the O work O the O role O of O the O Project O of O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61376099 O is O the O execution O of O simulations O the O roles O of O the O Major B-ORG Fundamental I-ORG Research I-ORG Program I-ORG of I-ORG Shaanxi I-ORG 2017ZDJC-26 O and O 111 B-ORG Project I-ORG B12026 O is O the O collection O analysis O and O interpretation O of O the O data O This O research O was O funded O by O the O Agence B-ORG Nationale I-ORG de I-ORG la I-ORG Recherche I-ORG ANR-15-CE16-0003-01 B-AWARD ANR-19-CE16-0017-03 B-AWARD ANR-20-CE16-0001-01 B-AWARD and O ANR-21-NEU2-0007-01 B-AWARD Eranet-Neuron O ROSSINI O project O to O A.P O Fondation B-ORG pour I-ORG la I-ORG recherche I-ORG médicale I-ORG Équipe O FRM O DEQ20130326521 B-AWARD and O EQU201903007836 B-AWARD to O A.P O ANR-Programme B-ORG d’Investissements I-ORG d’Avenir I-ORG ANR-18-RHUS-005 B-AWARD to O G.C O and O ANR-10-IAHU-01 B-AWARD to O the O Imagine B-ORG Institute O A.P O is O a O Centre O National O de O la O Recherche O Scientifique O CNRS O Investigator O and O P.B O is O a O one O from O the O Institut O National O de O la O Santé O et O de O la O Recherche O Médicale O INSERM O This O study O was O supported O by O 1) O National B-ORG Science I-ORG and I-ORG Technology I-ORG Infrastructure I-ORG Program I-ORG of I-ORG China I-ORG 2012BAI30B001 O Prof O Jing O Shang O 2) O One B-ORG Hundred I-ORG Person I-ORG Project I-ORG of I-ORG The I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Applied I-ORG Basic I-ORG Research I-ORG Programs I-ORG of I-ORG Qinghai I-ORG Province I-ORG Y229461211 O Prof O Jing O Shang O and O 3) O Science B-ORG and I-ORG Technology I-ORG Plan I-ORG Projects I-ORG in I-ORG Qinghai I-ORG Province I-ORG 2015-ZJ-733 O Prof O Jing O Shang O VENUS-PC O study O was O supported O by O Ministry O of O Health O Labor O and O Welfare O of O Japan O Grant O Number O H23-cancer-010 O The O present O study O was O performed O as O a O research O program O of O the B-ORG Project I-ORG for I-ORG Development I-ORG of I-ORG Innovative I-ORG Research I-ORG on I-ORG Cancer I-ORG Therapeutics I-ORG P-Direct O 11039020 B-AWARD The B-ORG Japan I-ORG Agency I-ORG for I-ORG Medical I-ORG Research I-ORG and I-ORG Development I-ORG AMED O 15cm0106085h0005 B-AWARD and O this O study O was O supported O in O part O by O a O grant O for O Leading B-ORG Advanced I-ORG Projects I-ORG for I-ORG Medical I-ORG Innovation I-ORG LEAP O 16am0001006h0003 B-AWARD from O the O Japan O Agency O for O Medical O Research O and O Development O This O work O was O financially O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2017YFE0103100 O International B-ORG Science I-ORG and I-ORG technology I-ORG cooperation I-ORG program I-ORG in I-ORG Guangdong I-ORG 2020A0505100048 O and O the O National B-ORG 111 I-ORG Project I-ORG No. O D17012 B-AWARD This O study O was O supported O by O the O International O Collaborative O Research O Grants O Scheme O with O joint O grants O from O the O Wellcome B-ORG Trust I-ORG UK I-ORG GR071587MA O and O the O Australian B-ORG National I-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG NHMRC O 268055 O and O as O a O global O health O grant O from O the O NHMRC O 585426 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81571144 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Tianjin I-ORG City I-ORG 16JCZDJC35700 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG 2018J01359 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Key B-ORG R&D I-ORG Program I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG Grant O No. O 2022ZX04A03 B-AWARD Science B-ORG Foundation I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG of I-ORG the I-ORG Heilongjiang I-ORG Academy I-ORG of I-ORG Sciences I-ORG Grant O No. O CXJQ2021SH01 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2020M670941 B-AWARD and O Postdoctoral B-ORG Science I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG of I-ORG China I-ORG Grant O No. O LBH-Z19203 B-AWARD and O Fundamental B-ORG Research I-ORG Funds I-ORG of I-ORG the I-ORG Heilongjiang I-ORG Provincial I-ORG Institutes I-ORG Grant O No. O CZKYF2021-2-C014 B-AWARD CZKYF2021-2-B002 B-AWARD and O CZKYF2021-2-A006 B-AWARD This O study O was O supported O by O Innovative B-ORG Research I-ORG Groups I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81721091 O National B-ORG S&T I-ORG Major I-ORG Project I-ORG of I-ORG China I-ORG 2017ZX100203205 O Research B-ORG Unit I-ORG of I-ORG Collaborative I-ORG Diagnosis I-ORG and I-ORG Treatment I-ORG For I-ORG Hepatobiliary I-ORG and I-ORG Pancreatic I-ORG Cancer I-ORG Chinese I-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG 2019-I2M-5-030/2019RU019 O This O study O was O also O supported O by O Zhejiang B-ORG Provincial I-ORG Public I-ORG Welfare I-ORG Technology I-ORG Research I-ORG Program I-ORG LGF18C100001 O Zhejiang B-ORG International I-ORG Science I-ORG and I-ORG Technology I-ORG Cooperation I-ORG Project I-ORG 2016C04003 O The O study O was O also O supported O by O the O National O S&T O Major O Project O of O China O 2018ZX10301201-008 O and O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC2000501 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 31601042 B-AWARD the O Science B-ORG Technology I-ORG and I-ORG Innovation I-ORG Commission I-ORG of I-ORG Shenzhen I-ORG Municipality I-ORG grant O numbers O JCYJ20151015162041454 B-AWARD and O JCYJ20160331150739027 B-AWARD and O by O the O Guangdong B-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Genome I-ORG Read I-ORG and I-ORG Write I-ORG grant O number O 2017B030301011 B-AWARD The O project O was O supported O in O part O by O award O numbers O 5R01AI048935 B-AWARD to O M.L O from O the O National B-ORG Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases I-ORG NIAID O and O 1F32GM97997 B-AWARD to O S.C O U01GM110721 B-AWARD to O C.F O and O U54GM088558 B-AWARD to O M.L O from O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG NIGMS O C.C O was O supported O by O EPSRC O Engineering O and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG UK) O EP/K026003/1 B-AWARD This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0200807 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31271818 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG Guidance I-ORG Project I-ORG of I-ORG Liaoning I-ORG Province I-ORG 2019-ZD-0711 O This O work O was O funded O byNational O Institute I-ORG of I-ORG Neurological I-ORG Disorders I-ORG and I-ORG Stroke10.13039/100000065grantNS076752;National O Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences10.13039/100000057grantGM0083222;National O Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute10.13039/100000050grantHL144047 O This O research O was O funded O by O the O UK B-ORG Research I-ORG and I-ORG Innovation I-ORG UKRI O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG BBSRC O grants O BB/M011224/1 B-AWARD BB/R012679/1 I-AWARD BB/P016472/1 I-AWARD BBS/E/I/00007030 I-AWARD BBS/E/I/00007031 I-AWARD BB/S013792/1 O British B-ORG Council I-ORG Newton O Fund O Institutional O Links O grant O IL3261727271 O and O the O UKRI O GCRF O One O Health O Poultry O Hub O grant O BB/S011269/1 O This O work O was O funded O by O the O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangdong O China O 2015A020208018 O and O 2017A040403069 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O China O 2016A030307016 O and O 2018A0303130161 B-AWARD Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Zhanjiang I-ORG City O China O 2016A03016 O and O College B-ORG Student I-ORG Climbing I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province O China O pdjh2019b0299 O There O is O on O role O of O the O funding O bodies O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O partially O supported O by O The B-ORG National I-ORG Cancer I-ORG Center I-ORG Research I-ORG and I-ORG Development I-ORG Fund I-ORG 25-A-1 O and I-AWARD 28-A-1 O the O Practical B-ORG Research I-ORG for I-ORG Innovative I-ORG Cancer I-ORG Control O and O the O Program B-ORG for I-ORG Promoting I-ORG Practical I-ORG Applications I-ORG of I-ORG Genomic I-ORG Medicine I-ORG from I-ORG the I-ORG Japan I-ORG Agency I-ORG for I-ORG Medical I-ORG Research I-ORG and I-ORG Development O AMED O 15ck0106097 O h0102 I-AWARD and O 15cK0106168 B-AWARD h0201 O This O research O was O funded O by O the O NSFC-Zhejiang B-ORG Joint I-ORG Fund I-ORG for I-ORG the I-ORG Integration I-ORG of I-ORG Industrialization I-ORG and I-ORG Informatization I-ORG U1909219 O Key B-ORG R&D I-ORG projects I-ORG in I-ORG Henan I-ORG province I-ORG 221111520200 O and O Anhui B-ORG Province I-ORG Key I-ORG Laboratory I-ORG of I-ORG Environment-friendly I-ORG Polymer I-ORG Materials I-ORG KF2022003 O This O research O was O funded O by O the O Science B-ORG Foundation I-ORG Ireland I-ORG SFI O Frontiers O for O the O Future O 2019 O call O 19/FFP/6522 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 51873179 O the O China B-ORG Scholarship I-ORG Council I-ORG CSC202008300033 O and O the O Irish B-ORG Research I-ORG Council I-ORG IRC O Government O of O Ireland O Postdoctoral O Fellowship O GOIPD/2022/209 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81602578 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG No. O ZR2017MH129 B-AWARD China B-ORG Pstdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2017M611177 B-AWARD and O the O Medical B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Plans I-ORG of I-ORG Shandong I-ORG No. O 2015WS0152 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41806199 O the O STU B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG for I-ORG Talents I-ORG NTF17006 O the O National B-ORG Program I-ORG for I-ORG Support I-ORG of I-ORG Top-Notch I-ORG Young I-ORG Professionals O the O Niche O Research O Grant O Scheme O 53131 O by O the O Malaysia’s O Ministry O of O Higher O Education O and O the O Program B-ORG for I-ORG Innovation I-ORG and I-ORG Enhancement I-ORG of I-ORG School I-ORG of I-ORG Department I-ORG of I-ORG Education I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017KCXTD014 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O authors O gratefully O acknowledge O Fundação B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG a I-ORG Tecnologia I-ORG FCT O through O projects O UIDB/04138/2020 B-AWARD UIDP/04138/2020 I-AWARD UIDB/00645/2020 I-AWARD UIDB/00100/2020 I-AWARD and I-AWARD UIDP/00100/2020 O M.N.A O would O like O to O thank O FCT B-ORG for I-ORG the I-ORG PhD I-ORG Fellowship I-ORG SFRH/BD/05377/2021 B-AWARD and O T.F.-G O for O the O PhD O Fellowship O SFRH/BD/147306/2019 B-AWARD J.P O is O supported O by O FCT B-ORG through I-ORG Estímulo I-ORG Individual I-ORG ao I-ORG Emprego I-ORG Científico I-ORG CEECIND/00394/2017 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Number O 81673014 B-AWARD Outstanding B-ORG Academic I-ORG Leaders I-ORG Plan I-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Committee I-ORG Grant O Number O 16XD1403100 B-AWARD and O National B-ORG Key I-ORG R&D I-ORG Plan I-ORG Grant O Number O 2017YFA0104600 B-AWARD This O work O was O supported O by O Qingdao B-ORG West I-ORG Coast I-ORG New I-ORG Area I-ORG 2020 I-ORG Annual I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 3-2-2020 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51674161 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG No. O ZR2017ZC0735 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 32172258 B-AWARD 31601519 B-AWARD the O Cultivation B-ORG Program I-ORG for I-ORG Young I-ORG Backbone I-ORG Teachers I-ORG in I-ORG Henan I-ORG University I-ORG of I-ORG Technology I-ORG No. O 21420089 B-AWARD and O the O Innovative B-ORG Funds I-ORG Plan I-ORG of I-ORG Henan I-ORG University I-ORG of I-ORG Technology I-ORG No. O 2021ZKCJ03 B-AWARD This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81570436 O WLC O Foundation B-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG 201640053 O WLC O Shanghai B-ORG Medical I-ORG Guiding I-ORG Project I-ORG 124119a6900 O WLC O This O work O was O sponsored O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 52164013 O Basic B-ORG Research I-ORG Funds I-ORG for I-ORG Colleges I-ORG and I-ORG Universities I-ORG directly I-ORG under I-ORG Inner I-ORG Mongolia I-ORG Autonomous I-ORG Region I-ORG 2022 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Inner I-ORG Mongolia I-ORG 2019LH02005 O Talent B-ORG Development I-ORG Fund I-ORG of I-ORG Inner I-ORG Mongolia I-ORG Autonomous I-ORG Region I-ORG 2021 O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Inner I-ORG Mongolia I-ORG Autonomous I-ORG Region I-ORG 2020GG0158 O This O work O was O supported O by O grants O from O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81470945 B-AWARD 81670638 B-AWARD the B-ORG Training I-ORG Program I-ORG of I-ORG the I-ORG Major I-ORG Research I-ORG Plan I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 91642120 O Capital B-ORG of I-ORG Clinical I-ORG Characteristics I-ORG and I-ORG the I-ORG Applied I-ORG Research I-ORG Fund I-ORG Z141107002514037 O Z161100000516005 B-AWARD Beijing B-ORG New-star I-ORG Plan I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Z161100004916167 O and O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0904102 O This O work O was O supported O by O the O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Youth I-ORG Fund I-ORG 81402456 O and O Science B-ORG and I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG province I-ORG China I-ORG 2015A030313255 O and O the B-ORG Social I-ORG Development I-ORG Project I-ORG of I-ORG Dongguan I-ORG NO. O 2016108101025 O The O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31972028 B-AWARD National O Natural O Science O Foundation O of O China O No. O 32272349 B-AWARD National O Natural O Science O Foundation O of O China O No. O 32202078 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2020KC010 O Key B-ORG R&D I-ORG Plan I-ORG of I-ORG Shandong I-ORG Province I-ORG No. O 2022CXGC010604 B-AWARD Qingdao B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Benefit I-ORG People I-ORG Project I-ORG No. O 20-3-4-34-nsh B-AWARD and O Foreign B-ORG Expert I-ORG Project I-ORG No. O G2022025008L B-AWARD This O work O was O supported O by O YZ201104,http://www.cas.cn B-AWARD Scientific B-ORG Equipment I-ORG Development I-ORG Project I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG CAS O Peng O Cai O 3502Z20126012,http://www.xminfo.net.cn B-AWARD Xiamen B-ORG Science I-ORG and I-ORG Technology I-ORG Plans I-ORG Project O Peng O Cai O and O 31270888 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O Hui-Yong O Lian O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O UK O Research O and O Innovation O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG BBSRC O BB/M011674/1 O to O PDBe O and O UniProt O Wellcome B-ORG Trust I-ORG 104948 O to O PDBe O European B-ORG Union I-ORG 284209 O to O PDBe O National B-ORG Institutes I-ORG of I-ORG Health I-ORG U41HG007822 O and O U24HG007822 B-AWARD to O UniProt O European O Molecular O Biology O Laboratory O EMBL O Funding O for O open O access O charge O EMBL O This O work O was O supported O by O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. I-AWARD 2015CB150200 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No.2016YFD0101300 O and O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG Key I-ORG Program I-ORG 2014CFA008 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O financial O support O of O this O work O were O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Henan I-ORG Province I-ORG of I-ORG China I-ORG Grant O No. I-AWARD 162300410158 O the B-ORG Distinguished I-ORG Talents I-ORG Foundation I-ORG of I-ORG Henan I-ORG Province I-ORG of I-ORG China I-ORG Grant O No. I-AWARD 174200510001 O Production-study-research B-ORG cooperation I-ORG of I-ORG Henan I-ORG Province I-ORG Grant O No. I-AWARD 152107000096 O and O the B-ORG National I-ORG key I-ORG research I-ORG and I-ORG development I-ORG Program I-ORG Grant O No. I-AWARD 2016YFD0600106 O This O research O was O funded O by O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-14 O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG CAAS-ASTIP-2016-OCRI O and O Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG 1610172018007 O The O funders O had O no O role O in O the O experimental O design O data O collection O and O analysis O or O writing O the O manuscript O This O work O was O funded O by O the O Sichuan B-ORG province’s I-ORG “14th I-ORG five-year I-ORG plan” I-ORG Sichuan I-ORG pig I-ORG major I-ORG science I-ORG and I-ORG technology I-ORG project I-ORG No. O 2021ZDZX0010 B-AWARD the O Chongqing B-ORG municipal I-ORG technology I-ORG innovation I-ORG and I-ORG application I-ORG development I-ORG project I-ORG No. O cstc2021jscx-dxwt B-AWARD BX0007 O the O research B-ORG and I-ORG integration I-ORG demonstration I-ORG of I-ORG key I-ORG technologies I-ORG for I-ORG improving I-ORG quality I-ORG and I-ORG efficiency I-ORG of I-ORG Sichuan I-ORG pig I-ORG industry I-ORG chain I-ORG No. O 2020YFN0147 B-AWARD and O the O agricultural B-ORG industry I-ORG technology I-ORG system I-ORG of I-ORG Sichuan I-ORG provincial I-ORG department I-ORG of I-ORG agriculture I-ORG No. O CARS-SVDIP B-AWARD This O study O was O funded O by O grants O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 72204275 B-AWARD 72074234 B-AWARD China B-ORG Medical I-ORG Board I-ORG grant O number O CMB-OC-19-337 B-AWARD and O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG grant O number O 2021A1515110364 B-AWARD 2022A1515011338 B-AWARD This O work O is O financially O supported O in O whole O or O in O part O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81572669 O 81602386 B-AWARD 81602378 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20151561 O BK20161564 B-AWARD BK20161024 B-AWARD A B-ORG Project I-ORG Funded I-ORG by I-ORG the I-ORG Priority I-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG 2014-37 O Natural B-ORG Scientific I-ORG Research I-ORG Project I-ORG for I-ORG College I-ORG in I-ORG Jiangsu I-ORG Province I-ORG 16KJB320002 O Project B-ORG from I-ORG Nanjing I-ORG Municipal I-ORG Committee I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 201803044 O and O Postgraduate B-ORG Research I-ORG I-ORG Practice I-ORG Innovation I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG KYCX18_1510 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 82230066 B-AWARD 82151316 B-AWARD 82171964 B-AWARD the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Hubei I-ORG Grant O Nos O 2020DCD015 B-AWARD 2021BCA138 B-AWARD and O the O Hubei B-ORG Natural I-ORG Science I-ORG Funds I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG 2021CFA046 O This O work O was O supported O by O funding O from O the O Canadian B-ORG Institutes I-ORG for I-ORG Health I-ORG Research I-ORG CIHR O Project O Number O MOP-74502 B-AWARD BC B-ORG Children’s I-ORG Hospital I-ORG Foundation I-ORG Project O Number O KRZ75146 B-AWARD and O BC B-ORG Child I-ORG and I-ORG Family I-ORG Research I-ORG Institute I-ORG CFRI O Project O Number O 20R20410 B-AWARD This O study O was O partially O sponsored O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81560452 B-AWARD and O 81672866 B-AWARD to O XBL O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Province I-ORG No. O 20161BAB205192 B-AWARD and O 20171ACB21073 B-AWARD to O XBL O the O Youth B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Province I-ORG No. O 20122BAB215028 B-AWARD to O ZPZ O Excellent B-ORG Youth I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Scientific I-ORG Committee I-ORG No. O 20162BCB23001 B-AWARD to O XBL O Science B-ORG and I-ORG Research I-ORG Fund I-ORG of I-ORG Jiangxi I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG No. O 20164002 B-AWARD to O XBL O The B-ORG Foundation I-ORG of I-ORG Nanchang I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG No. O 2016 B-AWARD ZSCX009 I-AWARD to O XBL O and O The O Yuanhang O Project O of O Jiangxi O Province O to O XBL O This O research O is O supported O by O a O grant O from O the B-ORG National I-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81500316 O to O Fan O Wang O MD. O a O grant O from O the B-ORG Open I-ORG Project I-ORG Program I-ORG of I-ORG the I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Proteomics I-ORG SKLP-O201508 O to O Fan O Wang O MD. O and O a O grant O from O the B-ORG Key I-ORG National I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2012CB517503 O 2013CB530804 O to O Ping O Ye, O MD. O This O study O was O supported O by O Chinese B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG 2016YFD0500505 O Chinese B-ORG Special I-ORG Fund I-ORG for I-ORG Agro-scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG 201303044 O and O Chinese B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-41-G13 O CAAS B-ORG Basic I-ORG Research I-ORG Business I-ORG Expenses I-ORG Y2017PT50 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31371747 O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shandong I-ORG province I-ORG 2018GNC113004 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG province I-ORG ZR2017BC018 O Great O Innovation O Program O of O Agricultural O Application O Technology O in O Shandong O province O and O Funds O of O Shandong O “Double O Tops” O Program O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31060027 O 31260037 B-AWARD 31460043 B-AWARD Project B-ORG for I-ORG Training I-ORG Young I-ORG Talents I-ORG of I-ORG Xinjiang I-ORG Uygur I-ORG Autonomous I-ORG Region I-ORG 2013721013 O and O the O Open B-ORG Funding I-ORG of I-ORG the I-ORG Xinjiang I-ORG Key I-ORG Laboratory I-ORG of I-ORG Biological I-ORG Resources I-ORG and I-ORG Genetic I-ORG Engineering I-ORG XJDX0201-2011-03 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Science B-ORG and I-ORG Technology I-ORG Research I-ORG Project I-ORG of I-ORG Jiangxi I-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG GJJ218108 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21701092 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG LY21B010002 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Ningbo I-ORG 2021J105 O 2022J104 B-AWARD This O study O was O financially O supported O by O The O Basic I-ORG Work I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG China O No. O 2011FY110300 B-AWARD National O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O No. O 31400173 B-AWARD Shandong O Province I-ORG Science I-ORG Foundation I-ORG for I-ORG Youths O No. O ZR2014CQ038 B-AWARD and O Science O and I-ORG Technology I-ORG Development I-ORG Plan I-ORG Project I-ORG of I-ORG Shandong I-ORG Province O No. O 2014GZX217005 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O developed O in O the O scope O of O the O mobilizing O project O TOOLING4G—Advanced B-ORG Tools I-ORG for I-ORG Smart I-ORG Manufacturing I-ORG POCI-01-0247-FEDER-024516 O Further O support O was O given O through O the O projects O with O reference O UIDB/00481/2020 B-AWARD UIDP/00481/2020 B-AWARD and O CENTRO-01-0145-FEDER-022083 B-AWARD financed O through O FCT—Fundação O para I-ORG a I-ORG Ciência I-ORG e I-ORG a I-ORG Tecnologia O Programa B-ORG Operacional I-ORG Regional I-ORG do I-ORG Centro I-ORG Portugal I-ORG Centro2020 O in O the O scope O of O PORTUGAL2020 B-AWARD through O the O European B-ORG Regional I-ORG Development I-ORG Fund O TG O and O MSC O thank O FCT O for O the O scholarships O with O reference O SFRH/BD/143429/2019 B-AWARD and O 2020.04681.BD B-AWARD respectively O This O research O was O supported O by O National B-ORG Key I-ORG New I-ORG Drug I-ORG Creation I-ORG and I-ORG Manufacturing I-ORG Program I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2018ZX09J18108-004 O the O Young B-ORG Scientists I-ORG Fund O National O Natural O Science O Foundation O of O China O No. O 81702733 B-AWARD and O the O Key O Projects O in O the O Key O Research O and O Development O Program O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 2017ZDXM-SF-021 O This O study O was O supported O by O the O grants O from O 2020 O Li B-ORG Ka I-ORG Shing I-ORG Foundation I-ORG Cross-Disciplinary O Research O Grant O 2020LKSFG01E O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2021A1515012470 O 2022A1515010540 B-AWARD Shantou B-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG Shanfuke O 2021)88-STKJ2021197 O Shanfuke B-AWARD 2020)53-51 O The O study O was O supported O partly O by O the O Fund O of O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC81560489 O NSFC B-AWARD 81260222 O the O Fund O of O Guangxi B-ORG Provincial I-ORG Health I-ORG Bureau I-ORG Scientific I-ORG Research I-ORG Project I-ORG Z2014054 O Youth B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangxi I-ORG Medical I-ORG University I-ORG GXMUYSF201311 O and O Guangxi B-ORG University I-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Projects I-ORG LX2014075 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82174120 O 81970991 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG No. O 21ZR1463100 B-AWARD Shanghai B-ORG Talent I-ORG Development I-ORG Funding I-ORG Scheme I-ORG No. O 2019090 B-AWARD and O Program B-ORG of I-ORG Shanghai I-ORG Academic I-ORG Research I-ORG Leader I-ORG 22XD1423400 O The O authors O acknowledge O Fundação B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG Tecnologia I-ORG FCT O for O financial O support O through O projects O UIDB/00645/2020 B-AWARD UIDB/04138/2020 B-AWARD UIDP/04138/2020 B-AWARD UIDB/04326/2020 B-AWARD UIDP/04326/2020 B-AWARD and O LA/P/0101/2020 B-AWARD and O also O the O PhD B-ORG fellowship I-ORG SFRH/BD/05377/2021 B-AWARD and O the O FCT B-ORG Scientific I-ORG Employment I-ORG Stimulus I-ORG CEECIND/00425/2017 O This O research O was O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2019YFB1600500 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51908054 O and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG CHD O 300102220202 O S.K O received O funding O from O Higher O Education O Commission O HEC O under O the O International B-ORG Research I-ORG Support I-ORG Initiative I-ORG Program I-ORG 1-8/HEC/HRD/2022/12612/IRSIP O 51 O Agri O 20 O M.Y O received O funding O from O HEC-National B-ORG Research I-ORG Program I-ORG for I-ORG Universities I-ORG NRPU-7018 O H.A O and O M.I.R O received O funding O from O HEC-Grand B-ORG Challenge I-ORG Fund I-ORG GCF-273 O Pakistan B-ORG Agriculture I-ORG Research I-ORG Board I-ORG PARB-18-476 O and O the O Punjab B-ORG Higher I-ORG Education I-ORG Commission I-ORG PHEC/ARA/PIRCA/2020-6/8 O The O authors O gratefully O acknowledge O grants O from O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFD0200506 B-AWARD the B-ORG National I-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 21462012 B-AWARD and O 21502032 B-AWARD and O the B-ORG Special I-ORG Fund I-ORG for I-ORG Outstanding I-ORG Scientific I-ORG and I-ORG Technological I-ORG Candidates I-ORG of I-ORG Guizhou I-ORG Province I-ORG No. O 201535 B-AWARD We O are O grateful O for O funding O support O from O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG XDJK2019C013 O the B-ORG Project I-ORG Funded I-ORG by I-ORG Chongqing I-ORG Special I-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O XmT2018080 O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFC1302204 I-AWARD and I-AWARD 2017YFC1308600 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81672502 O and O Research O and O Innovation O Project O of O Graduate O Students O in O Chongqing O CYS19136 O This O work O was O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG of I-ORG China I-ORG 2018A030313060 O Medical B-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG of I-ORG China I-ORG A2018191 O A2020178 B-AWARD A2020284 B-AWARD Guangzhou B-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 20201A011072 O and O Guangzhou B-ORG Medical I-ORG University I-ORG Project I-ORG B195001078 O This O study O was O part O of O the O TICKLESS O project O which O was O funded O by O the O Norwegian B-ORG Foundation I-ORG for I-ORG Research I-ORG Levy I-ORG on I-ORG Agricultural I-ORG Products I-ORG FFL I-ORG and I-ORG the I-ORG Agricultural I-ORG Agreement I-ORG Research I-ORG Funds I-ORG JA) I-ORG https://www.slf.dep.no/no/fou-midler/landbruks-og-matforskning O grant O nr O 207737 B-AWARD together O with O Møre B-ORG and I-ORG Romsdal I-ORG Council I-ORG www.mrfylke.no O grant O nr O 127/2009 B-AWARD and O the O County B-ORG Governor I-ORG in I-ORG Møre I-ORG and I-ORG Romsdal I-ORG www.fylkesmannen.no/More-og-Romsdal O grant O nr O 2010/5782/OTLO B-AWARD PSL O LG O and O IO O received O the O funding O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O design O of O the O study O and O collection O analysis O and O interpretation O of O data O were O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81572607 O 81502286 B-AWARD and O 81502299 B-AWARD The O collection O analysis O and O interpretation O of O data O were O supported O in O part O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20141023 O Writing O of O the O manuscript O was O supported O in O part O by O the O Program B-ORG for I-ORG Development I-ORG of I-ORG Innovative I-ORG Research I-ORG Team I-ORG in I-ORG the I-ORG First I-ORG Affiliated I-ORG Hospital I-ORG of I-ORG NJMU I-ORG IRT-008 O and O a O project O Funded O by O the O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG higher I-ORG Education I-ORG Institutions I-ORG PAPD O This O study O was O supported O by O the O Ontario B-ORG Ministry I-ORG of I-ORG Agriculture I-ORG Food I-ORG and I-ORG Rural I-ORG Affairs I-ORG OMAFRA O FS2016-3010 O to O BRD O Alberta B-ORG Agriculture I-ORG and I-ORG Forestry I-ORG AAF O 2016F013R O to O JDW O Natural B-ORG Sciences I-ORG and I-ORG Engineering I-ORG Research I-ORG Council I-ORG of I-ORG Canada I-ORG NSERC O Discovery O #222982 O to O JY O and O a O NSERC O Visiting B-AWARD Fellowship I-AWARD in I-AWARD Canadian I-AWARD Government I-AWARD Laboratories I-AWARD to O SJR O None O of O the O funding O agencies O had O any O role O in O the O design O of O the O study O the O collection O analysis O and O interpretation O of O data O nor O in O the O writing O of O the O manuscript O This O work O was O supported O by O grants O from O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDB13020300 O the O State B-ORG Key I-ORG Program I-ORG of I-ORG the I-ORG NSFC I-ORG 31330073 O and O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2014FY210200 O to O F.L O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2017YFA0204600 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 51802352 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2017M612996 B-AWARD GGC O received O a O scholarship O from O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG CAPES O grant O 88887.506391/2020-00 B-AWARD This O study O was O funded O by O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG Brazil I-ORG CNPq O 402387/2020-1 B-AWARD Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo I-ORG Brazil I-ORG FAPESP O 2020/06409-1 B-AWARD and O Fundação B-ORG Araucária I-ORG Brazil I-ORG PBA2022011000074 O SFY-O O and O ELD O were O funded O by O a O research O fellowship O from O CNPq O and O FAPESP O respectively O This O work O was O funded O in O part O by O the O High B-ORG Tech I-ORG Ship I-ORG Research I-ORG Project I-ORG of I-ORG Ministry I-ORG of I-ORG Industry I-ORG and I-ORG Information I-ORG Technology I-ORG Grant O No. O JJT2019MIT357 B-AWARD the O Key B-ORG Special I-ORG Project I-ORG for I-ORG Introduced I-ORG Talents I-ORG Team I-ORG of I-ORG Southern I-ORG Marine I-ORG Science I-ORG and I-ORG Engineering I-ORG Guangdong I-ORG Laboratory I-ORG Grant O No. O GML2019ZD0502 B-AWARD the O Sichuan B-ORG Key I-ORG Laboratory I-ORG Project I-ORG of I-ORG Artificial I-ORG Intelligence I-ORG Grant O No. O 2021RYY05 B-AWARD the O Open B-ORG Research I-ORG Project I-ORG of I-ORG Sichuan I-ORG Engineering I-ORG Laboratory I-ORG Grant O No. O WRXT2021-005 B-AWARD and O the O School B-ORG Level I-ORG Projects I-ORG of I-ORG Chengdu I-ORG Technological I-ORG University I-ORG Grant O No. O 2022ZR053 B-AWARD and I-AWARD 2022ZR054 O OPRAA O development O and O data O collection O was O funded O by O the O Scottish B-ORG Government I-ORG Joint B-AWARD Improvement I-AWARD Team O initial O data O transfer O by O an O NHS B-ORG Fife I-ORG R&D B-AWARD Bursary I-AWARD and O analysis O by O the O National O Institutes O for O Health O Research O Health B-ORG Services I-ORG and I-ORG Delivery I-ORG Research I-ORG Programme I-ORG NIHR O HS&DR I-AWARD 13/54/55 O The O views O and O opinions O expressed O therein O are O those O of O the O authors O and O do O not O necessarily O reflect O those O of O the O HS&DR O Programme O NIHR O NHS O or O the O Department O of O Health O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O grants O from O Guangzhou B-ORG Municipal I-ORG Bureau I-ORG of I-ORG Science I-ORG and I-ORG Information I-ORG No. O 2014J4100067 B-AWARD Guangdong B-ORG Provincial I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG No. O 2013B021800098 B-AWARD and O Natural B-ORG Science I-ORG Research I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81570751 B-AWARD The O study O was O supported O by O the O Russian B-ORG Science I-ORG Foundation I-ORG #17-14-01063 O the O Russian B-ORG Foundation I-ORG for I-ORG Basic I-ORG Research I-ORG #19-54-04008 O and O Lake B-ORG Baikal I-ORG Foundation I-ORG #02-3/14 O E.S O also O acknowledges O the O partial O support O from O the O Ministry O of O Science O and O Higher O Education O of O Russia O and O Deutscher O Akademischer O Austauschdienst O “Goszadanie” O 6.13468.2019/13.2 O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 51703180 B-AWARD 51720105016 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation O grant O number O 2017M610634 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province O grant O number O 2018JQ5195 B-AWARD Shaanxi B-ORG Province I-ORG Postdoctoral I-ORG Science I-ORG Foundation O grant O number O 2017BSHEDZZ73 B-AWARD Special O scientific O research O plan O project O of O Shaanxi O Provincial O Department O of O Education O grant O number O 13JS045 O and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities O grant O number O xjj2017024 B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 81701557 B-AWARD to O X.L O 81802503 B-AWARD to O H.Y O 81870017 B-AWARD to O Y.Y.Z O and O 81772180 B-AWARD to O K.L O Key B-ORG Projects I-ORG of I-ORG Natural I-ORG Science I-ORG Research I-ORG of I-ORG Universities I-ORG in I-ORG Anhui I-ORG Province I-ORG KJ2018A0265 O to O Y.Y.Z O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Province I-ORG 1908085QH380 O to O T.B.C O Funding O of O “Peak” O Training O Program O for O Scientific O Research O of O Yijishan O Hospital O Wannan O Medical O College O GF2019G10 O to O X.L.Z O and O GF2019G15 O to O H.Y O Key O Scientific O Research O Project O Training O Fund O of O Wannan O Medical O College O Grant O No. O WK2018ZF02 O to O H.Y O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81660557 B-AWARD and O 71764011 B-AWARD and O Jiangxi B-ORG Province I-ORG Focus I-ORG on I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG Grant O No. O 20171BBG70105 B-AWARD and O 20181BBG70033 B-AWARD and O Key B-ORG Laboratory I-ORG Plan I-ORG of I-ORG Jiangxi I-ORG Province I-ORG Grant O No. O 20192BCD40006 B-AWARD This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0200809 O the B-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Fund I-ORG Project I-ORG in I-ORG Hunan I-ORG Province I-ORG 2019LS01 O the B-ORG Project I-ORG of I-ORG Hunan I-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Fund I-ORG 2018ZD02-4 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 21177058 B-AWARD HG O got O funding O from O National O Natural O Science O Foundation O of O China O http://www.nsfc.gov.cn/english/site_1/index.html O and O supporting O study O design O data O collection O and O analysis O decision O to O publish O and O preparation O of O the O manuscript O This O work O was O also O supported O by O Program B-ORG of I-ORG New I-ORG Century I-ORG Excellent I-ORG Talents I-ORG in I-ORG University I-ORG NCET-12-0266 O HG O got O funding O from O Ministry O of O Education O of O the O People’s O Republic O of O China O http://en.moe.gov.cn O and O supporting O study O design O data O collection O and O analysis O International B-ORG S&T I-ORG Cooperation I-ORG Program I-ORG of I-ORG China I-ORG grant O no. O 31261140364 B-AWARD JZ O got O funding O from O Minstry O of O Science O and O Technology O of O the O People’s O Republic O of O China O http://www.most.gov.cn/eng O and O supporting O study O design O data O collection O and O analysis O Knowledge B-ORG Innovation I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG grant O no. O KZCX-SW-440 B-AWARD JZ O got O funding O from O Chinese O Academy O of O Sciences O http://english.cas.cn O and O supporting O study O design O data O collection O and O analysis O and O the O German B-ORG Research I-ORG Foundation I-ORG FZT O 118 O NE O got O funding O from O German O Research O Foundation O http://www.dfg.de/en O and O supporting O preparation O of O the O manuscript O This O work O was O supported O by O “National O Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG Project O No. O 2017YFD0500901)” B-AWARD “China O Agriculture I-ORG Research I-ORG System I-ORG No. O CARS-36)” B-AWARD “National O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Project O No. O 31572487 B-AWARD 31873005 O “the O MoSTRCUK I-ORG international I-ORG cooperation I-ORG project I-ORG Project O No. O 2013DFG32500)” B-AWARD and O “the O High-end O Foreign O Experts O Recruitment O Program O Project O No. O GDW20151100036 B-AWARD GDW20161100071)” O This O work O was O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61103178 O Natural B-ORG Science I-ORG Basic I-ORG Research I-ORG Plan I-ORG in I-ORG Shaanxi I-ORG Province I-ORG of I-ORG China I-ORG 2016JM6002 O I-AWARD 2015JM6294 O and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 3102015JSJ0003 O LSZ O was O partially O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0201000 O YYH O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31901946 O WX O was O supported O by O the O Department B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Jilin I-ORG Province I-ORG China I-ORG 20180201015NY O and I-AWARD 20190103102JH O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangzhou I-ORG Municipality I-ORG No. O 201607010272 B-AWARD Special B-ORG Foundation I-ORG of I-ORG Public I-ORG Welfare I-ORG Research I-ORG and I-ORG Capacity I-ORG Building I-ORG of I-ORG Guangdong I-ORG Province I-ORG Nos O 2017A010105012 B-AWARD 2016A030303060 B-AWARD National B-ORG Major I-ORG Scientific I-ORG and I-ORG Technological I-ORG Special I-ORG Project I-ORG for I-ORG “Significant I-ORG New I-ORG Drugs I-ORG Development” I-ORG of I-ORG China I-ORG 2013ZX09103003-003 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31501894 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG of I-ORG China I-ORG No. O 2015A030310036 B-AWARD Medical B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG of I-ORG China I-ORG No. O A2016091 B-AWARD the B-ORG Joint I-ORG Natural I-ORG Sciences I-ORG Fund I-ORG of I-ORG the I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG and I-ORG the I-ORG First I-ORG Affiliated I-ORG Hospital I-ORG of I-ORG Guangdong I-ORG Pharmaceutical I-ORG University I-ORG No. O GYFYLH201312 B-AWARD This O study O was O funded O by O the O David B-ORG and I-ORG Lucile I-ORG Packard I-ORG Foundation I-ORG https://www.packard.org O grant O number O 2014-40476 B-AWARD the O Swedish B-ORG International I-ORG Development I-ORG Cooperation I-ORG Agency I-ORG http://www.sida.se/English O grant O number O ID O 61050130 B-AWARD and O the O UK B-ORG Government I-ORG https://www.gov.uk/government/organisations/department-for-international-development O grant O number O 203177-101 B-AWARD The B-ORG Beijing I-ORG Natural I-ORG Science I-ORG Foundation I-ORG grant O No. O 7142130 B-AWARD the O Specialized B-ORG Research I-ORG Fund I-ORG for I-ORG the I-ORG Doctoral I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG grant O No. O 2013110611000 B-AWARD the O Capital B-ORG Health I-ORG Research I-ORG and I-ORG Development I-ORG of I-ORG Special I-ORG grant O No. O 2011-4001-03 B-AWARD Peking B-ORG Union I-ORG Medical I-ORG College I-ORG New I-ORG Star I-ORG 2011 O for I-AWARD LJ) O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O No. O 81570195 B-AWARD supported O this O research O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Spanish O Ministry O of O Science O Innovation O and O Universities O grant O number O MINECO/FEDER-MAT2015-65274-R O the O Spanish O Research O Agency O AEI O Ministry O of O Research O and O Innovation O and O the O European B-ORG Regional I-ORG Development I-ORG Fund I-ORG ERDF O grant O number O TEC2017-82464-R B-AWARD B.S O acknowledges O the O postdoctoral O grant O from O the O “Atracción O de O Talento” O Program O awarded O by O the O Comunidad B-ORG de I-ORG Madrid I-ORG 2017-T2/IND-5465 O R.A O acknowledges O the O European B-ORG Social I-ORG Fund I-ORG ESF O and O the O Youth O Employment O Initiative O YEI O of O the O Madrid O region O through O the O PEJD-2018-PRE/IND-8916 B-AWARD grant O This O work O was O supported O by O Jiangxi B-ORG Provincial I-ORG Education I-ORG Department I-ORG GJJ161094 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51469017 O 51579127 B-AWARD 51769015 B-AWARD 51779005 B-AWARD and O Jiangxi B-ORG Provincial I-ORG Technology I-ORG Department I-ORG 20171ACB21050 O The O research O was O financially O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hainan I-ORG Province I-ORG 318QN265 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31701492 O 31861143013 I-AWARD 31672483 O the O Modern B-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG CARS-34 O CARS-22-Z11 O and O the O Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG for I-ORG CATAS I-ORG 1630032018004 O The O authors O declare O that O none O of O the O funding O bodies O have O any O role O in O the O design O of O the O study O or O collection O analysis O interpretation O of O data O and O writing O the O manuscript O This O study O was O financially O supported O by O the O grants O from O National B-ORG Cheng I-ORG Kung I-ORG University I-ORG D106-35A13 O D107-F2519 O and O NCKUH-10709001 B-AWARD and O from O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG MOST-108-2314-B-006-094 O and O from O China B-ORG Medical I-ORG University I-ORG CMU101-ASIA-07 O Taiwan O all O of O which O are O through O a O contract O awarded O to O S.N O Wu. O This O work O was O supported O by O the O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O Project O nos O 81702023 B-AWARD 81772222 B-AWARD and O 81572025 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20171049 O and O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG of I-ORG China I-ORG 17KJB310003 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O preparation O of O the O manuscript O or O decision O to O publish O D.E O is O thankful O to O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq I-ORG for I-ORG a I-ORG Master’s I-ORG scholarship I-ORG process O 149404/2018-2 B-AWARD and O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG Capes I-ORG for I-ORG a I-ORG PhD I-ORG process O 88887.352040/2019-00 B-AWARD scholarship O M.P.F O is O grateful O to O FAPESP B-ORG for O a O PhD O scholarship O process O 2016/13862-9 B-AWARD D.L.A.d.F O is O indebted O to O FAPESP O for O research O grants O FAPESP O 2012/13119-3 B-AWARD and O 2016/21070-5 B-AWARD V.R.L.C O is O grateful O to O CNPq O 314034/2021-8 O and O the O São B-ORG Paulo I-ORG Research I-ORG Foundation I-ORG FAPESP O INCT-INEO B-AWARD 2014/50869-6 O for O the O research O grants O This O work O was O part O of O the O Research B-ORG Academic I-ORG Cooperation I-ORG Agreement I-ORG PRC-CNRS-FAPESP I-ORG PRC-Projets O de O recherché O conjoints O 1688 B-AWARD and O SPRINT-São B-ORG Paulo I-ORG Researchers I-ORG in I-ORG International I-ORG Collaboration I-ORG 2016/50317-9 B-AWARD This O work O was O financially O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2019YFA0904800 O the O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG Grant O no. O 19ZR1413600 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG WF1814032 O 22221818014 B-AWARD This O study O was O supported O by O Grants O from O the B-ORG Chinese I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O no. O 81671616 B-AWARD and I-AWARD 81471603 O Jiangsu B-ORG Provincial I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Foundation I-ORG Grant O no. O H201317 B-AWARD and I-AWARD H201623 O Science B-ORG Foundation I-ORG of I-ORG Nantong I-ORG City I-ORG Grant O no. O MS32015021 B-AWARD MS2201564 I-AWARD and I-AWARD MS22016028 O Science B-ORG and I-ORG Technology I-ORG Foundation I-ORG of I-ORG Nantong I-ORG City I-ORG Grant O no. O HS2014071 B-AWARD and I-AWARD HS2016003 O the B-ORG College I-ORG graduate I-ORG research I-ORG and I-ORG innovation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grant O no. O KYZZ15_0353 B-AWARD and I-AWARD KYZZ16_0358 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81870838 O No.81671311 B-AWARD the B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Liaoning I-ORG Province I-ORG No.2018225004 O Liaoning B-ORG Province I-ORG Distinguished I-ORG Professor I-ORG Support I-ORG Program I-ORG No.XLYC1802096 O and O the B-ORG Outstanding I-ORG Scientific I-ORG Fund I-ORG of I-ORG Shengjing I-ORG Hospital I-ORG No.201708 O The O authors O gratefully O acknowledge O the O support O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 52071238 B-AWARD O U20A20279 B-AWARD National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2022YFB3706701 O Guangdong B-ORG Key I-ORG Areas I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG 2019B111106002 O and O the O 111 B-ORG Project I-ORG No. O D18018 B-AWARD This O work O was O supported O by O theWellcome O Trust(103722/Z14/Z O and O theBBSRC(L021005/1 O to O JPA O and O by O a O jointAlzheimer’s O Society I-ORG and I-ORG BRACE I-ORG research I-ORG fellowshipto O CM-B O grant O 208/506818 B-AWARD The O study O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O number O 31400970 B-AWARD to O L. O W., O 81771533 B-AWARD to O Y. O K O the O National B-ORG Key I-ORG project I-ORG Grant O number O 2018YFC1003000 B-AWARD to O Y. O K O and O the O grants O from O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG Grant O number O 18ZR1422600 B-AWARD to O L. O W O The O work O was O supported O by O the B-ORG National I-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2011AA10A214 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31502115 O and O the B-ORG National I-ORG Program I-ORG for I-ORG Risk I-ORG Assessment I-ORG of I-ORG Quality I-ORG and I-ORG Safety I-ORG of I-ORG Livestock I-ORG and I-ORG Poultry I-ORG Products I-ORG GJFP2016008 O VN O was O supported O by O a O FPI O pre-doctoral O scholarship O BES-2012-053741 O from O Ministerio B-ORG de I-ORG Economía I-ORG y I-ORG Competitividad O JO O was O supported O by O Severo O Ochoa O SEV-2012-0262 O and O Ramón O y O Cajal O RYC-2013-12501 O research O fellowships O This O work O received O financial O support O from O research O grants O CGL2011-25053 B-AWARD Ministerio O de O Ciencia O e O Innovación O and O European O Social O Fund O POII10-0197-0167 B-AWARD PEII-2014-023-P B-AWARD Junta O de I-ORG Comunidades I-ORG de I-ORG Castilla-La I-ORG Mancha I-ORG and O European O Social O Fund O and O UNCM08-1E-018 B-AWARD European O Regional I-ORG Development I-ORG Fund O This O work O was O supported O by O the O National O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81400106 O the O Shanghai B-ORG Young I-ORG Doctor I-ORG Training I-ORG Program I-ORG 2015 O and O the O Doctoral B-ORG Innovation I-ORG Fund I-ORG Projects I-ORG from I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG School I-ORG of I-ORG Medicine I-ORG BXJ201407 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG General O Program O Grant O Numbers O 81874338 O 81773852 B-AWARD the O Major B-ORG Expenditure I-ORG Increase I-ORG and I-ORG Reduction I-ORG Project I-ORG at I-ORG the I-ORG Central I-ORG Level I-ORG “Capacity O Building O for O Sustainable O Utilization O of O Precious O Traditional O Chinese O Medicine O Resources” O Grant O Number O 2060302 B-AWARD and O the O Liaoning B-ORG Province I-ORG Education I-ORG Department I-ORG Liaoning O Higher O School O Outstanding O Young O Scholar O Growth O Plan O Grant O Number O LJQ2014101 B-AWARD This O work O has O been O supported O by O “UTE O project O CIMA” O European B-ORG Union O grant O no. O HEALTH-F2-2010-258677 B-AWARD Spanish B-ORG Ministry I-ORG of I-ORG Economy I-ORG and I-ORG Innovation I-ORG and O Fondo O de O Investigación O Sanitaria-Fondo O Europeo O de O Desarrollo O Regional O ISCIII-RTICC O PI10/00166 I-AWARD PI13/00806 O RD12/0036/0040 B-AWARD RD12/0036/0062 B-AWARD RD12/0036/0063 B-AWARD Government B-ORG of I-ORG Navarra I-ORG Department I-ORG of I-ORG Health I-ORG 21/2009 O and O AECC B-ORG Scientific I-ORG Foundation I-ORG GCB14-2170 O This O work O was O supported O by O the O Youth B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Zhangjiagang I-ORG TCM I-ORG Hospital I-ORG Affiliated I-ORG to I-ORG Nanjing I-ORG University I-ORG of I-ORG Chinese I-ORG Medicine I-ORG ZZYQ2009 O Zhangjiagang B-ORG City I-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG project I-ORG ZKS2125 O and O Suzhou B-ORG Medical I-ORG Health I-ORG Science I-ORG and I-ORG technology I-ORG innovation I-ORG project I-ORG SKYD2022047 O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 22205139 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG 22ZR1437800 O Shanghai B-ORG Sailing I-ORG Program I-ORG 20YF1424500 O The B-ORG National I-ORG Natural I-ORG Science I-ORG Funds I-ORG 81473624 O Innovation B-ORG Project I-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Education I-ORG Commission I-ORG 12YZ057 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 78210021 O This O study O is O supported O in O part O by O Taiwan B-ORG Ministry I-ORG of I-ORG Health I-ORG and I-ORG Welfare I-ORG Clinical I-ORG Trial I-ORG and I-ORG Research I-ORG Center I-ORG of I-ORG Excellence I-ORG MOHW105-TDU-B-212-133019 O China B-ORG Medical I-ORG University I-ORG Hospital I-ORG Academia I-ORG Sinica I-ORG Taiwan I-ORG Biobank I-ORG Stroke I-ORG Biosignature I-ORG Project I-ORG BM10501010037 O NRPB B-ORG Stroke I-ORG Clinical I-ORG Trial I-ORG Consortium I-ORG MOST O 104-2325-B-039 I-AWARD 005 O Tseng-Lien O Lin O Foundation O Taichung O Taiwan O Taiwan O Brain O Disease O Foundation O Taipei O Taiwan O and O Katsuzo O and O Kiyo O Aoshima O Memorial O Funds O Japan O and O CMU O under O the O Aim O for O Top O University O Plan O of O the O Ministry O of O Education O Taiwan O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O No O additional O external O funding O received O for O this O study O This O study O was O supported O by O grants O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFA0202104 O to O SCY O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81803029 O to O LL O the O Key B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG ChongQing I-ORG cstc2019jcyj-zdxmX0023 O to O LG O and O the O Key B-ORG Clinical I-ORG Research I-ORG Program I-ORG of I-ORG Southwest I-ORG Hospital I-ORG SWH2017ZDCX1003 O to O SCY O The O work O was O supported O by O Beijing O Municipal O Science O O Technology O Commission O No. O Z191100006619052 O the O Beijing B-ORG Hospitals I-ORG Authority I-ORG Incubating I-ORG Program I-ORG PX2018060 O the O Beijing B-ORG Hospitals I-ORG Authority I-ORG Youth I-ORG Programme I-ORG QML20181803 O The B-ORG capital I-ORG health I-ORG research I-ORG and I-ORG development I-ORG of I-ORG special I-ORG 2022-1-2172 O High-level B-ORG Public I-ORG Health I-ORG Technical I-ORG Personnel I-ORG Training I-ORG Program I-ORG of I-ORG Beijing I-ORG Municipal I-ORG Health I-ORG Commission I-ORG 2022-3-050 O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG China I-ORG 2017ZX10201201-001-006 O 2017ZX10201201-002-006 O 2018ZX10715-005-003-005 O APL O was O supported O by O a O PhD O grant O from O the O Portuguese B-ORG National I-ORG Funding I-ORG Agency I-ORG for I-ORG Science I-ORG Research I-ORG and I-ORG Technology O Fundação O para O a O Ciência O e O a O Tecnologia O SFRH/BD/116082/2016 O MRH O was O supported O by O the O Dutch B-ORG Arthritis I-ORG Association I-ORG RF-14-2-301 O TR O was O funded O by O an O ERC B-ORG starting I-ORG grant I-ORG ERC-2011-StG O Circumvent O This O study O was O funded O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81772779 B-AWARD “Professionals B-ORG from I-ORG Six-Pronged I-ORG Top-Talent I-ORG Program” I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O LGY2017068 B-AWARD “The B-ORG Six I-ORG Top I-ORG Talent I-ORG Project” I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O 2015-WSN-034 B-AWARD Medical B-ORG Talent I-ORG of I-ORG Empowering I-ORG Medicine I-ORG through I-ORG Science I-ORG and I-ORG Education I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O ZDRCA2016003 B-AWARD and O Key B-ORG Laboratory I-ORG for I-ORG Medicine I-ORG of I-ORG Jiangsu I-ORG Province I-ORG of I-ORG China I-ORG No. O ZDXKB2016005 B-AWARD This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2021YFD1000301 O the O National B-ORG Modern I-ORG Agriculture I-ORG Industry I-ORG Technology I-ORG System I-ORG China I-ORG CARS-05 O and O the B-ORG Priority I-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG China I-ORG PAPD O This O study O received O support O from O the O European B-ORG Commission I-ORG under I-ORG the I-ORG 7th I-ORG Framework I-ORG Programme I-ORG through O the O Action—IMCONet O FP7 O IRSES I-AWARD action I-AWARD no. I-AWARD 318718 B-AWARD The O participation O of O Michael O Meredith O in O this O research O was O funded O by O the O Natural B-ORG Environment I-ORG Research I-ORG Council I-ORG via O awards O NE/N018095/1 B-AWARD and I-AWARD NE/P003060/1 O K.J O acknowledges O funding O from O AWI B-ORG DFG I-ORG SSP I-ORG 1158 I-ORG Grant O JE B-AWARD 680/1-1 O Marie B-ORG Curie I-ORG Action I-ORG FP I-ORG 7 I-ORG IRSES I-ORG Action O No. O 318718 O E.R.B O was O funded O by O Instituto B-ORG Antártico I-ORG Argentino O Funding O from O PICT B-AWARD 2011-1320-ANPCyT I-AWARD to O I.S O is O acknowledged O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O grant O number O 11631012 B-AWARD YX) I-AWARD and O 11571273 B-AWARD YX O by O the O National B-ORG Mega-project I-ORG of I-ORG Science I-ORG Research I-ORG grant O number O 2017ZX10201101-002-002 B-AWARD YX O and O by O the O National O Natural O Science O Foundation O of O China O NSFC O grant O number O 11701442(XS)).LR O was O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG DMS-1758290 O LAM O and O SEB O were O supported O by O the O US B-ORG National I-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG Model I-ORG of I-ORG Infectious I-ORG Disease I-ORG Agent I-ORG Study I-ORG grant O U01GM087719 B-AWARD to O LAM O and O APG O and O SEB O was O supported O by O a O National B-ORG Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases I-ORG K01 I-ORG award I-ORG K01AI125830 O This O project O was O supported O through O the O National O Institute O of O Child O Health O and O Human O Development O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH O Department O of O Health O and O Human O Services O contract O number O HHSN267200700023C B-AWARD the O National B-ORG Institute I-ORG of I-ORG Environmental I-ORG Health I-ORG Sciences I-ORG NIEHS O award O number O 5P01ES009601 B-AWARD 5P30ES007033 B-AWARD and O the O U.S O Environmental B-ORG Protection I-ORG Agency I-ORG U.S O EPA O grant O RD83451401 B-AWARD The O content O is O solely O the O responsibility O of O the O authors O and O does O not O represent O the O official O views O of O the O NIEHS O the O NIH O or O the O U.S O EPA O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81601053 B-AWARD and O No. O 81401000 B-AWARD the O Scientific B-ORG Research I-ORG Project I-ORG of I-ORG Liaoning I-ORG Province I-ORG Department I-ORG of I-ORG Education I-ORG No. O LK201636 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Liaoning I-ORG No. O 2012408002 B-AWARD This O work O was O supported O by O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG No, O 2017-I2M-3-017 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 11801301 O and O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O Z190024 O This O work O was O supported O by O the B-ORG Major I-ORG Scientific I-ORG and I-ORG Technological I-ORG Special I-ORG Project I-ORG for I-ORG ‘Significant I-ORG New I-ORG Drugs I-ORG Formulation’ I-ORG Grant O Numbers O 2015ZX09501001-001-003 B-AWARD 2012ZX09501001 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Number O 81374011 B-AWARD and O the B-ORG Special I-ORG Project I-ORG for I-ORG the I-ORG National I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG Industry I-ORG of I-ORG China I-ORG Grant O Number O 201507004 B-AWARD This O project O was O funded O by O a O Marine B-ORG Environmental I-ORG Observation I-ORG Prediction I-ORG and I-ORG Response I-ORG MEOPAR I-ORG Early-Career I-ORG Faculty I-ORG Development I-ORG Grant I-ORG awarded I-ORG to I-ORG Brett I-ORG Favaro I-ORG EC1-BF-MUN O Nicci O Zargarpour O was O supported O by O an O Ocean B-ORG Industry I-ORG Student I-ORG Research I-ORG Award I-ORG from I-ORG the I-ORG Research I-ORG and I-ORG Development I-ORG Corporation I-ORG of I-ORG Newfoundland I-ORG and I-ORG Labrador I-ORG 5404-1914-101 O Funding O was O also O provided O by O the O Canadian B-ORG Centre I-ORG for I-ORG Fisheries I-ORG Innovation I-ORG H-2015-06 O and O the O Newfoundland B-ORG and I-ORG Labrador I-ORG Department I-ORG of I-ORG Fisheries I-ORG and I-ORG Aquaculture I-ORG currently I-ORG Department I-ORG of I-ORG Fisheries I-ORG and I-ORG Land I-ORG Resources I-ORG Fisheries I-ORG Development I-ORG and I-ORG Diversification I-ORG Fund I-ORG NH-77836 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O National B-ORG Health I-ORG Department I-ORG of I-ORG China I-ORG grant O no. O 2018ZX10101003 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 31770161 B-AWARD and O Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Committee I-ORG grants O no. O 14DZ2272900 B-AWARD 14495800500 O The O contribution O of O Prof O Daan O Kromhout O to O this O article O was O funded O by O the O Royal O Netherlands O Academy O of O Arts O and O Sciences O Financial O support O was O obtained O from O the O Dutch B-ORG Kidney I-ORG Foundation I-ORG PV41 O by O Dr. O Ellen O K. O Hoogeveen O the B-ORG Netherlands I-ORG Heart I-ORG Foundation I-ORG 2000T401 O and O US O National B-ORG Institutes I-ORG of I-ORG Health I-ORG HL076200 O by O Prof O Daan O Kromhout O The O grant O from O the O Dutch O Kidney O Foundation O covered O baseline O examinations O of O kidney O function O The O grant O of O the O Netherlands O Heart O Foundation O covered O baseline O examinations O and O mortality O follow-up O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O by O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2014CB138305 O the O National B-ORG Nonprofit I-ORG Institute I-ORG Research I-ORG Grant I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG CAAS O IARRP-647-46 O and O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS20 O Project O 2014CB138305 O funded O the O mapping O and O data O analyses O project O IARRP-647-46 O CAAS O funded O the O 2b–RAD O sequencing O and O genotyping O project O CARS20 O funded O the O whole O genome O sequencing O and O analyses O This O work O was O financially O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC1100402 O the O International B-ORG Cooperation I-ORG Project I-ORG by I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2020YFH0103 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC I-ORG Project O 81801853 B-AWARD Postdoctoral B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 2018M633400 O and O Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG 19GJHZ0058 O This O work O was O supported O by O the O grants O from O the O Interdisciplinary B-ORG Research I-ORG Matching I-ORG Scheme I-ORG IRMS I-ORG of I-ORG Hong I-ORG Kong I-ORG Baptist I-ORG University I-ORG RC-IRMS/12-13/02 O to O APL O the O Hong B-ORG Kong I-ORG Baptist I-ORG University I-ORG Strategic I-ORG Development I-ORG Fund I-ORG SDF13-1209-P01 O to O APL O and O SDF15-0324-P02(b O to O APL O the O Inter-institutional B-ORG Collaborative I-ORG Research I-ORG Scheme I-ORG of I-ORG Hong I-ORG Kong I-ORG Baptist I-ORG University I-ORG RC-ICRS/16-17/01 O to O APL O the O Faculty B-ORG Research I-ORG Grant I-ORG of I-ORG Hong I-ORG Kong I-ORG Baptist I-ORG University I-ORG FRG1/14-15/070 O and O FRG2/15-16/038 B-AWARD to O DGG O and O the O Natural B-ORG Science I-ORG Foundation I-ORG Council I-ORG of I-ORG China I-ORG 31501080 O to O DGG O The O funders O had O no O involvement O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O corresponding O authors O have O full O access O to O all O the O data O in O the O study O and O had O final O responsibility O for O the O decision O to O submit O for O publication O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32070630 O for O J.Z O and O 31970555 B-AWARD for O Y.G O Medical B-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Provincial I-ORG Health I-ORG Commission I-ORG 2019KY574 O for O Y.G O and O the B-ORG Zhejiang I-ORG Innovation I-ORG Team I-ORG Grant O 2020R01006 O for O Y.G O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O U1504817 B-AWARD 81670088 B-AWARD the O Foundation B-ORG of I-ORG Science I-ORG I-ORG Technology I-ORG Department I-ORG of I-ORG Henan I-ORG Province I-ORG China I-ORG Nos O 182102310335 B-AWARD 172102410019 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Education I-ORG Department I-ORG of I-ORG Henan I-ORG Province I-ORG China I-ORG No. O 15A310017 B-AWARD and O the O Science B-ORG Foundation I-ORG of I-ORG Henan I-ORG University I-ORG China I-ORG Nos O yqpy20170044 B-AWARD 16NB048 B-AWARD Funding O bodies O did O not O have O any O influence O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O or O in O writing O the O manuscript O This O work O was O supported O by O Zhejiang B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG grants O no. O GF20H020041 B-AWARD to O HS, O LGD19H160001 B-AWARD to O JKT O Shaoxing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG grant O no. O 2018C30016 B-AWARD to O FXL O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grants O No. O 81772537 B-AWARD to O JKT O 81374014 B-AWARD to O JKT O This O work O was O supported O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG 1U01HL137183-01 O and O 5U54HG007990 B-AWARD to O W.B O A.N O G.H O J.C O and O B.P O and O the O W. B-ORG M. I-ORG Keck I-ORG Foundation I-ORG DT06172015 O W.B O was O also O funded O by O the O Google O Summer O of O Code O programme O D.Z O was O supported O by O the O Wellcome B-ORG Trust I-ORG WT201535/Z/16/Z O WT108749/Z/15/Z B-AWARD and O the O the O European O Molecular O Biology O Laboratory O This O work O was O founded O by O the B-ORG National I-ORG Nature I-ORG Science I-ORG Foundation I-ORG 31501761 O 31372067 O to O ZL, O the B-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-23-A8 O to O ZL, O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0101805 O to O ZL, O as O well O as O the B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG CAAS-ASTIP-IVFCAAS O to O ZL. O This O work O was O supported O by O the O Royal B-ORG Golden I-ORG Jubilee I-ORG Ph. I-ORG D. I-ORG Program I-ORG PHD/0142/2553 O the O Center O of O Excellence O in O Material O Science O and O Technology O Chiang O Mai O University O and O the O Research O Center B-ORG of I-ORG Excellence I-ORG on I-ORG Biodiversity I-ORG BDC-PG2-159012 O under O Thailand’s O Office O of O the O Higher O Education O Commission O are O thankfully O acknowledged O The O MRL O Shared O Experimental O Facilities O at O UCSB O are O supported O by O the O MRSEC B-ORG Program I-ORG of I-ORG the I-ORG NSF I-ORG under O Award O No. O DMR B-AWARD 1720256 O a O member O of O the O NSF-funded O Materials O Research O Facilities O Network O www.mrfn.org O There O is O no O conflict O of O interest O This O work O was O supported O by O Jiangsu B-ORG provincial I-ORG clinical I-ORG medical I-ORG project I-ORG No.BL2014100 O Basic B-ORG clinical I-ORG research I-ORG of I-ORG national I-ORG Tradition I-ORG Chinese I-ORG Medicine I-ORG project I-ORG No. O JDZX2012087 O and O Jiangsu O provincial O health O project O No. O BJ14013 O Changzhou B-ORG Municipal I-ORG Health I-ORG Technology I-ORG projects I-ORG No. O WZ201529 O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81870199 O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2015CB943300 O the O Foundation B-ORG for I-ORG Innovative I-ORG Research I-ORG Group I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31521003 O and O Opening O program O 2018 O of O the B-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Genetic I-ORG Engineering I-ORG SKLGE1809 O This O study O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No.31901677 O the O High-Level B-ORG Research I-ORG Startup I-ORG Foundation I-ORG of I-ORG Henan I-ORG University I-ORG of I-ORG Technology I-ORG Grant O No.2019BS021 O the O Cultivation B-ORG Programme I-ORG for I-ORG Young I-ORG Backbone I-ORG Teachers I-ORG in I-ORG Henan I-ORG University I-ORG of I-ORG Technology I-ORG Grant O No.21420167 O the O China B-ORG Scholarship I-ORG Council I-ORG supported O Yingyuan O Zhao O CSC O No.202008410088 O the O Science B-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Henan I-ORG Province I-ORG Grant O No.212102311045 O and O the O Innovative B-ORG Funds I-ORG Plan I-ORG of I-ORG Henan I-ORG University I-ORG of I-ORG Technology I-ORG Grant O No.2020ZKCJ23 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 82101253 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2042021kf0104 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG 2022CFB108 O This O research O was O supported O by O the O Foundation B-ORG for I-ORG Research I-ORG Support I-ORG of I-ORG Para I-ORG FAPESPA O protocol O 005/2015 B-AWARD by O the O Coordination B-ORG for I-ORG the I-ORG Improvement I-ORG of I-ORG Higher I-ORG Education I-ORG Personnel I-ORG CAPES O Scholarships O and O National O Academic O Cooperation O Program O in O the O Amazon–PROCAD/Amazônia O grant O number O 21/2018 B-AWARD and O the O National B-ORG Council I-ORG of I-ORG Technological I-ORG and I-ORG Scientific I-ORG Development I-ORG CNPq O grant O number O 305821/2017-2 B-AWARD and O 176827/2022-6 B-AWARD and O the O Dean B-ORG of I-ORG Research I-ORG and I-ORG Graduate I-ORG Studies I-ORG PROPESP I-ORG from I-ORG the I-ORG Federal I-ORG University I-ORG of I-ORG Pará I-ORG Grant O support O 02/2023 B-AWARD This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31601312,https://isisn.nsfc.gov.cn/egrantweb O to O L.Z O Chongqing B-ORG Postdoctoral I-ORG Special I-ORG Foundation I-ORG Xm2015047,http://www.cstc.gov.cn O to O L.Z O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG SWU114035 O to O L.Z O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O by O the B-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-10-B08 O the B-ORG Modern I-ORG Agricultural I-ORG Technology I-ORG System I-ORG of I-ORG Tubers I-ORG and I-ORG Root I-ORG Crops I-ORG in I-ORG Shandong I-ORG Province I-ORG SDAIT-16-09 O the B-ORG Agricultural I-ORG Variety I-ORG Project I-ORG in I-ORG Shandong I-ORG Province I-ORG 2017LZGC011 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61601393 O 11604276 B-AWARD and O 11501481 B-AWARD the O Shenzhen O Science O and O Technology O Innovation O Committee O Project O No. O 201887656 O JCYJ20170306141755150 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG of O China O 2016J01321 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG of O China O 2015A030310009 O and O 2016A030310372 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82071746 O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Projects I-ORG in I-ORG Sichuan I-ORG Province I-ORG 2019YFS0043 O the O Key B-ORG R&D I-ORG project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2021YFS0107 O and O the O 1·3·5 O Project I-ORG for I-ORG Disciplines I-ORG of I-ORG Excellence I-ORG West I-ORG China I-ORG Hospital I-ORG Sichuan I-ORG University I-ORG ZY2017302-1.3.5 O Esther O García-de O Blas O was O supported O by O a O predoctoral O grant O JAE-PRE O from O the O Consejo B-ORG Superior I-ORG de I-ORG Investigaciones I-ORG Científicas I-ORG CSIC O co-financed O by O Fondo O Social O Europeo O EU O This O study O was O funded O by O Consejería B-ORG de I-ORG Educación I-ORG y I-ORG Ciencia I-ORG Junta I-ORG de I-ORG Comunidades I-ORG de I-ORG Castilla I-ORG la I-ORG Mancha I-ORG project O ref O PII1I09-0271-5037 B-AWARD and O Ministerio B-ORG de I-ORG Economía I-ORG y I-ORG Competitividad I-ORG CGL2009-10883-C02-02 O and O CGL2015-69338-C2-2-P B-AWARD from O the O Spanish O Government O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82071984 O H. O Z O Project B-ORG of I-ORG Social I-ORG Development I-ORG Guiding I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Zhenjiang I-ORG City I-ORG FZ2021055 O X. O C O the O Infectious B-ORG and I-ORG Inflammatory I-ORG Radiology I-ORG Committee I-ORG of I-ORG Jiangsu I-ORG Research I-ORG Hospital I-ORG Association I-ORG GY202205 O X. O C.) O and O the O Postgraduate B-ORG Innovation I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG SJCX21_1730 O Y. O H O This O work O was O supported O by O the O grant O from O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFC1001904 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG for O Young O Scholars O No. O 81501386 B-AWARD and O Tianjin B-ORG Medical I-ORG University I-ORG 13th O 5-year O postgraduate O Innovation O Fund O No. O YJSCX201705 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Number O 81402738 B-AWARD Fujian B-ORG Program I-ORG for I-ORG Outstanding I-ORG Young I-ORG Researchers I-ORG in I-ORG University I-ORG awarded I-ORG by I-ORG Education I-ORG Department I-ORG of I-ORG Fujian I-ORG Grant O Number O 2017B019 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O Number O 2017YFC0907100 B-AWARD Fujian B-ORG Provincial I-ORG Health I-ORG Research I-ORG Talents I-ORG Training I-ORG Programme I-ORG Medical I-ORG Innovation I-ORG Project I-ORG Grant O Number O 2019-CX-33 B-AWARD and O Fujian B-ORG Provincial I-ORG Health I-ORG Research I-ORG Talents I-ORG Training I-ORG Programme I-ORG Youth I-ORG Research I-ORG Project I-ORG Grant O Number O 2019-1-58 B-AWARD This O research O was O funded O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51802162 B-AWARD the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O BK20180955 B-AWARD and O the B-ORG Jiangsu I-ORG Water I-ORG Conservancy I-ORG Science I-ORG and I-ORG Technology I-ORG project I-ORG No. O 2020043 B-AWARD The O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 21775168 B-AWARD National O Key O R&D O Program O of O China O No. O 2017YFE0102400 O Department B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2017A020211004 B-AWARD Shenzhen O Research O Funding O Program O No. O JCYJ20180307155036127 O and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 191gpy211 B-AWARD partly O supported O this O work O The O China O Scholarship O Council O also O partly O supported O this O work O The O research O was O funded O by O the O 2020 B-ORG Shenzhen I-ORG International I-ORG Scientific I-ORG and I-ORG Technological I-ORG Cooperation I-ORG R&D I-ORG Project I-ORG GJHZ20190823111601682 O the O Basic B-ORG Research I-ORG Project I-ORG of I-ORG Shenzhen I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Commission I-ORG No. O JCYJ20190813105005619 B-AWARD the O Shenzhen B-ORG Dapeng I-ORG New I-ORG District I-ORG Industrial I-ORG Development I-ORG Fund I-ORG KY20180203 O the O Shenzhen B-ORG Dapeng I-ORG New I-ORG District I-ORG Scientific I-ORG and I-ORG Technological I-ORG Research I-ORG and I-ORG Development I-ORG Fund I-ORG KJYF202001-07 O the O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG 2020A1515011075 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2018A030307046 O This O research O was O also O supported O by O the O Development B-ORG Project I-ORG about I-ORG Marine I-ORG Economy I-ORG Demonstration I-ORG of I-ORG Zhanjiang I-ORG City I-ORG XM-202008-01B1 O and O the O Southern B-ORG Marine I-ORG Science I-ORG and I-ORG Engineering I-ORG Guangdong I-ORG Laboratory I-ORG Zhanjiang O ZJW-2019-07 B-AWARD This O work O was O supported O by O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG for I-ORG Significant I-ORG New I-ORG Drugs I-ORG Development I-ORG 2018ZX09735004 O Marine B-ORG S&T I-ORG Fund I-ORG of I-ORG Shandong I-ORG Province I-ORG for I-ORG Pilot I-ORG National I-ORG Laboratory I-ORG for I-ORG Marine I-ORG Science I-ORG and I-ORG Technology I-ORG Qingdao O 2018SDKJ0401-2 O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC0311105 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2018MD021 O and O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31000361 O This O research O is O supported O by O the O NIH O National B-ORG Institute I-ORG on I-ORG Aging I-ORG Grant O number O R01 B-AWARD AG041776 O NIH B-ORG National I-ORG Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute I-ORG Grant O number O R01 B-AWARD HL103706 O and O the O NIH O Office B-ORG of I-ORG Dietary I-ORG Supplements I-ORG Grant O number O R01 B-AWARD HL103706-S1 O The O Atherosclerosis O Risk O in O Communities O Study O is O carried O out O as O a O collaborative O study O supported O by O National O Heart O Lung O and O Blood O Institute O contracts O HHSN268201100005C O HHSN268201100006C I-AWARD HHSN268201100007C I-AWARD HHSN268201100008C I-AWARD HSN268201100009C I-AWARD HHSN268201100010C I-AWARD HHSN268201100011C I-AWARD and I-AWARD HHSN268201100012C O The O authors O thank O the O staff O and O participants O of O the O ARIC O study O for O their O important O contributions O This O work O was O supported O by O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81803467 O 81803466 B-AWARD 111 B-ORG project I-ORG B16047 O and O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2018M633259 B-AWARD M.J.D O APP1141606 O is O supported O by O funding O from O the O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council O T.L.B O is O supported O by O an O Investigator O Grant O from O the O National O Health O and O Medical O Research O Council O C.E.C O is O supported O by O an O NHMRC O Senior O Research O Fellowship O and O a O University O of O Newcastle O Faculty O of O Health O and O Medicine O Gladys O M O Brawn O Senior O Research O Fellowship O E.S O is O supported O by O an O National O Health O and O Medical O Research O Council O Senior O Research O Fellowship O AP1110526 O and O a O University O of O Sydney O SOAR O Fellowship O This O project O is O partly O supported O by O Diabetes B-ORG Australia I-ORG General O Grant O Y17G-DUNM O and O the O National B-ORG Heart I-ORG Foundation I-ORG of I-ORG Australia I-ORG 101584 O 100629 B-AWARD This O work O was O funded O by O Chang-hua B-ORG Christian I-ORG Hospitalhttp://www.cch.org.tw/(101-CCH-IRP-28 O recipient O JKK O Taichung B-ORG Veterans I-ORG General I-ORG Hospitalhttp://www.vghtc.gov.tw/home/index.html/(TCVGH-1047307C O recipient:JJS O The B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Taiwanhttps://www.most.gov.tw/(MOST-103-2320-B-005-003 O MOST-104-2320-B-005-009-MY3 O recipient O JJS O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31970351 O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shanxi I-ORG Province I-ORG China I-ORG 2022NY-193 O and O the O Xi’an B-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG 22NYYF001 O This O study O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 52002373 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG for I-ORG Young I-ORG Scientists I-ORG of I-ORG Henan I-ORG Province I-ORG Grant O No. O 202300410071 B-AWARD Joint B-ORG Construction I-ORG Project I-ORG of I-ORG Henan I-ORG Medical I-ORG Science I-ORG and I-ORG Technology I-ORG Gran O No. O LHGJ20220103 B-AWARD Postdoctoral O Research O Grant O in O Henan O Province O Grant O No. O 202101026 O and O Young O Talents O Program O of O Henan O University O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81903537 O and O 81601189 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2018BB024 O ZR2019MC026 B-AWARD and O ZR2016HM57 B-AWARD Medical B-ORG and I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Foundation I-ORG of I-ORG Shandong I-ORG 2017WS801 O Traditional B-ORG Chinese I-ORG Medicine I-ORG Technology I-ORG Development I-ORG Foundation I-ORG of I-ORG Shandong I-ORG 2019-0521 O Science B-ORG and I-ORG Technology I-ORG Development I-ORG Foundation I-ORG of I-ORG Binzhou I-ORG 2015ZC0304 O and O Research B-ORG Foundation I-ORG of I-ORG Binzhou I-ORG Medical I-ORG University I-ORG BY2015KYQD31 O and O BY2017KJ17 B-AWARD This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 61701015 B-AWARD Beijing B-ORG Natural I-ORG Science I-ORG Foundation O grant O number O 3202017 B-AWARD Commercial O Aircraft O Corporation O of O China O Ltd O grant O number O COMAC-SFGS-2017-36740 O and O Chinese B-ORG Aeronautical I-ORG Establishment O grant O number O 2017ZF51077 B-AWARD The O current O study O was O supported O by O the O following O funds O Technology B-ORG Support I-ORG Plan I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Sichuan I-ORG Province I-ORG Grant O No. O 2014SZ0210 B-AWARD Foundation B-ORG of I-ORG Sichuan I-ORG University I-ORG for I-ORG Outstanding I-ORG Youth I-ORG Grant O No. O 2014SCU04B21 B-AWARD Foundation B-ORG for I-ORG Academic I-ORG Leader I-ORG Fostering I-ORG of I-ORG Personnel I-ORG Department I-ORG of I-ORG Sichuan I-ORG Province I-ORG Grant O No. O JH2014053 B-AWARD Key B-ORG Project I-ORG for I-ORG Applied I-ORG Research I-ORG of I-ORG Organization I-ORG Department I-ORG of I-ORG Sichuan I-ORG Provincial I-ORG Party I-ORG Committee I-ORG Grant O No. O JH2015017 B-AWARD and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81470927 B-AWARD This O research O was O supported O in O part O by O i) O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 72202110 B-AWARD and O 72172069 B-AWARD ii) O the O Humanities B-ORG and I-ORG Social I-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG No. O 20YJC630185 B-AWARD and O iii O Social B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O 19GLB003 B-AWARD This O research O was O funded O by O the O Beijing B-ORG Municipal I-ORG Natural I-ORG Science I-ORG Foundation O grant O number O 6182022 B-AWARD the O Chinese B-ORG Universities I-ORG Scientific I-ORG Fund O grant O number O 2018QC062 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 31301593 B-AWARD and O the O National O Natural O Science O Foundation O of O China O grant O number O 31501435 B-AWARD This O work O was O partly O supported O by O the O following O funding O resources O High-level B-ORG Talent I-ORG Gathering I-ORG Program I-ORG in I-ORG Hunan I-ORG Province I-ORG China I-ORG 2018RS3107 O NIH B-ORG GM084198,MH109665 O NSFC B-ORG 31671384,81890990 O Stand B-ORG Up I-ORG To I-ORG Cancer-Cancer I-ORG Research I-ORG UK-Lustgarten I-ORG Foundation I-ORG Pancreatic I-ORG Cancer I-ORG Dream I-ORG Team I-ORG Research I-ORG Grant O SU2C-AACR-DT-20-16 O This O study O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC1305500 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61671479 B-AWARD the O National O Natural O Science O Foundation O of O China O No. O 61471399 B-AWARD Innovation B-ORG Nursery I-ORG Fund I-ORG of I-ORG PLA I-ORG General I-ORG Hospital I-ORG No. O 15KMZ04 B-AWARD and O the O National O Natural O Science O Foundation O of O China O No. O 81401719 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O system O of O National B-ORG Modern I-ORG Agriculture I-ORG Technology I-ORG CARS-06-13.5-A28 O the O Scientific B-ORG and I-ORG Technological I-ORG Project I-ORG in I-ORG Shanxi I-ORG Province I-ORG China I-ORG 20150311016-2 O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG General I-ORG Project I-ORG in I-ORG Shanxi I-ORG Province I-ORG China I-ORG 201603D221003-2 O the O Key B-ORG Scientific I-ORG and I-ORG Technological I-ORG Project I-ORG of I-ORG Shanxi I-ORG Province I-ORG 2015-TN-09 O and O the O Program O for O the O Top B-ORG Young I-ORG Innovative I-ORG Talents I-ORG of I-ORG Shanxi I-ORG Agricultural I-ORG University I-ORG TYIT201406 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O ACT B-ORG Health I-ORG Contracts O 2013.21920.590 B-AWARD to O KG O and O 2015.275404.340 B-AWARD to O MB O At O the O time O of O undertaking O the O research O MB O was O supported O by O Australian B-ORG Research I-ORG Council I-ORG Discovery O Early O Career O Researcher O Award O DE150100637 B-AWARD and O KG O was O supported O by O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG Senior O Research O Fellowship O 1059620 B-AWARD The O funding O bodies O played O no O role O in O data O collection O analysis O or O preparation O of O the O manuscript O The O study O was O funded O by: O Medical B-ORG Research I-ORG Council I-ORG JFr O MR/L006588/1 O Swiss B-ORG National I-ORG Science I-ORG Foundation I-ORG MH) O PBBSB O 116880 O and O Wellcome B-ORG Trust I-ORG JW, O RP, O SF) O 069598/Z/02/Z O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O National B-ORG System I-ORG of I-ORG Modern I-ORG Agriculture I-ORG Industrial I-ORG Technology I-ORG Project O CARS-03-05 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0300909 O Scientific B-ORG Research I-ORG Project I-ORG of I-ORG Hebei I-ORG Education I-ORG Department I-ORG QN2019046 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG C2019204358 O This O work O was O supported O by O Ministry B-ORG of I-ORG Health I-ORG and I-ORG Welfare I-ORG grant O MOHW107-TDU-B212-114010 O and O MOHW108-TDU-B212-124010 B-AWARD to O A.L.Y O and O T.-T.W O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG grant O MOST O 106-2314-B-038-032-MY2 I-AWARD and O MOST108-2314-B-038-061-MY3 B-AWARD to O T.-T.W O Taipei B-ORG Medical I-ORG University I-ORG Hospital I-ORG grant O 105TMU-TMUH-01-01 O and O 106TMU-TMUH-01-1 B-AWARD to O T.-T.W O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 51508344 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG grant O number O 2016M591458 O Department B-ORG of I-ORG Education I-ORG of I-ORG Liaoning I-ORG Province I-ORG grant O number O L2015449 O and O Doctoral B-ORG Start-up I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province I-ORG grant O number O 201601212 O This O work O was O funded O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31371757 O State B-ORG Key I-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG of I-ORG China I-ORG No. O 31330060 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China-Shandong I-ORG Joint I-ORG Fund I-ORG for I-ORG Marine I-ORG Science I-ORG Research I-ORG Centers I-ORG U1606403 O and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 201762028 O This O work O was O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG MCB-0943393 O the O NSF B-ORG Materials I-ORG Network I-ORG grant O no. O DMR-1108350 O the O David B-ORG and I-ORG Lucille I-ORG Packard I-ORG Foundation I-ORG 2011-37152 O the O Department B-ORG of I-ORG Defense I-ORG Army I-ORG Research I-ORG Office I-ORG W911NF-14-1-0259 O and O the O John B-ORG Templeton I-ORG Foundation I-ORG FP053369-A//39147 O A.J.H O was O supported O by O the O NIH B-ORG training I-ORG grant I-ORG in I-ORG Cellular I-ORG and I-ORG Molecular I-ORG Basis I-ORG of I-ORG Disease I-ORG 2-T32GM008061-31 O and O the O Northwestern O University O Presidential O Fellowship O Cefas B-ORG toxin O work O conducted O partially O using O funds O from O the O EU O Interreg B-ORG Atlantic O Area O AlertoxNet B-AWARD project O together O with O internal O Seedcorn B-AWARD funding O Andres O Santos O work O was O supported O by O the O grants O CONICYT-Doctorado O Nacional-2017-21171392 O and O Universidad B-ORG de I-ORG La I-ORG Frontera I-ORG CD-FRO1204 B-AWARD This O research O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG grant O number O LY21E020010 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG of I-ORG Zhejiang I-ORG Sci-Tech I-ORG University I-ORG grant O number O 2021Y005 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 52102315 B-AWARD The O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31702081 B-AWARD the O Modern B-ORG Agricultural I-ORG Industrial I-ORG System I-ORG Special I-ORG Funding I-ORG CARS-43-A-1 O and O the O Science B-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG New I-ORG Variety I-ORG Breeding I-ORG Livestock I-ORG and I-ORG Poultry I-ORG of I-ORG Zhejiang I-ORG Province I-ORG China I-ORG 2016C02054-10 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Dr. O Jinjun O Chen O was O supported O by O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG 2018ZX10723203 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81270533 O 81470038 B-AWARD National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0908100 O the B-ORG Specialized I-ORG Research I-ORG Fund I-ORG for I-ORG the I-ORG Doctoral I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG of I-ORG China I-ORG 20124433120016 O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 863 O program I-AWARD 2012AA022605 O Key B-ORG Scientific I-ORG and I-ORG Technological I-ORG Program I-ORG of I-ORG Guangzhou I-ORG City I-ORG 201508020262 O and O Department B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2014B020228003 O 2015B020226004 B-AWARD Dr. O Tingting O Qi O was O supported O by O President B-ORG Foundation I-ORG of I-ORG Nanfang I-ORG Hospital I-ORG Southern I-ORG Medical I-ORG University I-ORG 2017C047 O The O funders O had O no O role O in O the O design O of O the O study O collection O analysis O and O interpretation O of O data O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG China I-ORG Grant O No. B-AWARD 2018JJ3844 O the O Scientific B-ORG Research I-ORG Project I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG Hunan I-ORG Province I-ORG China I-ORG Grant O No. B-AWARD B2019188 O the B-ORG Youth I-ORG Science I-ORG Foundation I-ORG of I-ORG Xiangya I-ORG Hospital I-ORG Central I-ORG South I-ORG University I-ORG Grant O No. B-AWARD 2017Q07 O the B-ORG Postdoctoral I-ORG Research I-ORG Program I-ORG of I-ORG Xiangya I-ORG Hospital I-ORG Central I-ORG South I-ORG University I-ORG Grant O No. B-AWARD 223551 O the O Postdoctoral O Research O Program O of O Hunan O university O of O TCM O Grant O No. O 194780 O Fundings O include O the O cost O of O collecting O the O fellow-up O data O and O publication O fee O This O research O was O funded O by O the O American B-ORG Chemical I-ORG Society I-ORG Petroleum O Research O Fund O grant O number O 65275-UNI6 B-AWARD the O Eppley B-ORG Foundation I-ORG for I-ORG Research O grant O number O 1023 B-AWARD and O Rowan B-ORG University I-ORG Seed B-AWARD Funds O The O APC O was O funded O by O Rowan O University O Libraries O This O research O was O funded O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG grants O TL1 B-AWARD TR000449 O DK094416 B-AWARD Nutrition B-ORG Obesity I-ORG Research I-ORG Center I-ORG Grant O DK56341 B-AWARD Diabetes B-ORG Research I-ORG Center I-ORG Grant O DK20579 B-AWARD and O Clinical B-ORG and I-ORG Translational I-ORG Science I-ORG Award I-ORG RR024992 B-AWARD There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 22278183 O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2022YFD2101400 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20210463 O the O Special B-ORG Fund I-ORG from I-ORG Post-doctor I-ORG Innovation I-ORG Research I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG SDCX-ZG-202203049 O and O the O Independent B-ORG Projects I-ORG for I-ORG Young I-ORG Scholars I-ORG at I-ORG Jiangnan I-ORG University I-ORG JUSRP122011 O Special B-ORG Funds I-ORG for I-ORG Marine I-ORG Fishery I-ORG Science I-ORG and I-ORG Technology I-ORG Promotion I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG grant O No. O A201501B11 B-AWARD to O Dr. O Xue-Ming O Dan O Finance B-ORG Supporting I-ORG Specific I-ORG Projects I-ORG for I-ORG Fish I-ORG Diseases I-ORG Control I-ORG from I-ORG the I-ORG Government I-ORG of I-ORG Guangdong I-ORG Province I-ORG grant O No. O YCN[2016]11H B-AWARD to O Dr. O Yan-Wei O Li. O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O No. O 31272681 B-AWARD to O Dr. O An-Xing O Li. O We O acknowledge O the O support O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81473082 O 81703333 B-AWARD and O 81602608 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O China O 2017A030313078 O and O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2016A020209009 O 2016B020211002 B-AWARD and O 510093637143 B-AWARD This O work O was O funded O by O Beijing B-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospitals I-ORG Incubating I-ORG Program I-ORG grant O number I-AWARD PX2019034 O National B-ORG Institutes I-ORG of I-ORG Health I-ORG grant O number I-AWARD R21 I-AWARD AI123558-01 O the O Peking B-ORG Union I-ORG Medical I-ORG College I-ORG Graduate I-ORG Innovation I-ORG Foundation I-ORG grant O number I-AWARD 2018-1002-01-25 O Tsinghua B-ORG University I-ORG Medicine-Engineering I-ORG Scientific I-ORG Collaboration I-ORG and I-ORG Innovation I-ORG Support I-ORG Plan I-ORG the I-ORG Capital I-ORG Health I-ORG Research I-ORG and I-ORG Development I-ORG of I-ORG Special I-ORG grant O number I-AWARD 2018-1-2171 O Beijing B-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospital I-ORG Clinical I-ORG Medicine I-ORG Development I-ORG of I-ORG Special I-ORG Funding I-ORG Support(grant O number I-AWARD ZYLX201802 O This O work O was O supported O by O the O Project O Program O of O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81303077,81971088 O The B-ORG Project I-ORG of I-ORG Medicine I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG of I-ORG Shandong I-ORG 2017WS268 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2018LH012 O ZR2019BH033 B-AWARD The O funders O had O no O role O in O the O study O design O data O analysis O and O interpretation O of O these O data O writing O the O manuscript O and O the O decision O to O publish O the O results O This O research O was O supported O by O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG no. O 2020M680640 B-AWARD Hubei B-ORG Humanities I-ORG and I-ORG Social I-ORG Sciences I-ORG Key I-ORG Research I-ORG Base I-ORG Dabie I-ORG Mountain I-ORG Tourism I-ORG Economy I-ORG and I-ORG Culture I-ORG Research I-ORG Center I-ORG no. O 203202224004 B-AWARD 2022 B-ORG Humanities I-ORG and I-ORG Social I-ORG Sciences I-ORG Research I-ORG Project I-ORG of I-ORG Hubei I-ORG Provincial I-ORG Education I-ORG Department I-ORG no. O 22Q258 B-AWARD This O work O was O supported O by O Zhejiang B-ORG Provincial I-ORG administration I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG 2013ZA012 O Zhejiang B-ORG Provincial I-ORG Health I-ORG Department I-ORG 2011KYB018 O and O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG LY15H180009 O This O work O was O supported O by O the O Basic O Research O Program O NRF-2017R1C1B2010278 O and O the O Nano⋅Material O Technology O Development O Program O NRF-2016M3A7B4900121 O through O a O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O grant O funded O by O the O Ministry O of O Science O and O ICT O Also O this O research O has O been O conducted O with O the O support O of O the O Korea B-ORG Institute I-ORG of I-ORG Industrial I-ORG Technology I-ORG kitech O JA-19-0001 O and O the O Gyeonggi-Do B-ORG Technology I-ORG Development I-ORG Program I-ORG kitech O IZ-19-0003 O as O “development O of O smart O textronic O products O based O on O electronic O fibers O and O textiles” O This O study O was O funded O by O the O Wereld B-ORG Kanker I-ORG Onderzoek I-ORG Fonds I-ORG WKOF I-ORG as I-ORG part I-ORG of I-ORG the I-ORG World I-ORG Cancer I-ORG Research I-ORG Fund I-ORG International I-ORG grant I-ORG programme I-ORG grant O number O 2016/1620 B-AWARD The O EnCoRe O study O is O also O funded O by O grants O from O the O Stichting B-ORG Alpe I-ORG d'HuZes I-ORG within I-ORG the I-ORG research I-ORG program I-ORG Leven I-ORG met I-ORG kanker I-ORG of I-ORG the I-ORG Dutch I-ORG Cancer I-ORG Society I-ORG Grant O No. O UM-2010-4867 B-AWARD and O UM-2012-5653 B-AWARD by O grants O from O Kankeronderzoekfonds B-ORG Limburg I-ORG as I-ORG part I-ORG of I-ORG Health I-ORG Foundation I-ORG Limburg I-ORG Grant O No. O 00005739 B-AWARD and O by O a O grant O of O the O Wereld O Kanker O Onderzoek O Fonds O WKOF O as O part O of O the O World O Cancer O Research O Fund O International O grant O programme O grant O number O 2017/1619 B-AWARD E.H O van O Roekel O is O funded O by O the O Wereld O Kanker O Onderzoek O Fonds O WKOF O as O part O of O the O World O Cancer O Research O Fund O International O grant O programme O grant O number O 2016/1620 O J.J.L O Breedveld-Peters O was O funded O and O J.L O Koole O is O currently O funded O by O Kankeronderzoekfonds O Limburg O as O part O of O Health O Foundation O Limburg O Grant O No. O 00005739 O M. O Kenkhuis O is O funded O by O the O Wereld O Kanker O Onderzoek O Fonds O WKOF O as O part O of O the O World O Cancer O Research O Fund O International O grant O programme O grant O number O 2017/1619 O This O study O was O funded O by O China B-ORG Scholarship I-ORG Council I-ORG no. O 201908110337 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 81672201 B-AWARD no. O 81871794 B-AWARD and O Beijing B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG no. O PXM2017 B-AWARD 026283 I-AWARD 000002 O This O work O was O supported O by O funding O from O the B-ORG Strategic I-ORG Priority I-ORG Research I-ORG Program I-ORG B) I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDB03030403 O the B-ORG National I-ORG Basic I-ORG Research I-ORG Program I-ORG 2013CB956000 O and O the B-ORG National I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41230750 O and I-AWARD 31272488 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31470757 O the O ShuGuang B-ORG Project I-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Education I-ORG Commission I-ORG and I-ORG Shanghai I-ORG Education I-ORG Development I-ORG Foundation I-ORG 17SG19 O the O Outstanding B-ORG Yong I-ORG Medical I-ORG Scholar I-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning(2017YQ067 O the O Program B-ORG for I-ORG Professor I-ORG of I-ORG Special I-ORG Appointment I-ORG Eastern I-ORG Scholar I-ORG at I-ORG the I-ORG Shanghai I-ORG Institutions I-ORG of I-ORG Higher I-ORG Learning I-ORG 1410000159 O the O SMC-ChenXing B-ORG Yong I-ORG Scholar I-ORG Program I-ORG 2014 O Class I-AWARD B), O the O Shanghai B-ORG Municipal I-ORG Education I-ORG Commission-Gaofeng I-ORG Clinical I-ORG Medicine I-ORG Grant I-ORG 20161317 O the O Science O and O Technology O Commission O of O Shanghai O 17DZ2260100 O and O the O Outstanding B-ORG Yong I-ORG Scholar I-ORG Grant I-ORG of I-ORG Shanghai I-ORG JiaoTong I-ORG University I-ORG School I-ORG of I-ORG Medicine I-ORG 16XJ11002 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31601021 B-AWARD 31620103910 B-AWARD 81874181 I-AWARD 91440203 O 81772512 B-AWARD 81672404 O the B-ORG Emerging I-ORG Frontier I-ORG Program I-ORG of I-ORG Hospital I-ORG Development I-ORG Center I-ORG No. O SHDC12018107 B-AWARD the B-ORG General I-ORG Surgery I-ORG Construction I-ORG Program I-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Health I-ORG Commission I-ORG No. O 2017ZZ02011 B-AWARD Xinhua B-ORG Hospital I-ORG PI-startup I-ORG funds I-ORG No. O JZPI201716 B-AWARD the B-ORG Project I-ORG of I-ORG Excellent I-ORG Young I-ORG Scholars I-ORG from I-ORG Shanghai I-ORG Municipal I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG No. O 2018YQ10 B-AWARD the B-ORG Talent I-ORG Development I-ORG Fund I-ORG from I-ORG Shanghai I-ORG Municipal I-ORG Human I-ORG Resources I-ORG and I-ORG Social I-ORG Security I-ORG Bureau I-ORG No. O 2018048 B-AWARD Shanghai B-ORG Pujiang I-ORG Program I-ORG No. O 17PJ1406100 B-AWARD and O Shanghai B-ORG Key I-ORG Laboratory I-ORG of I-ORG Biliary I-ORG Tract I-ORG Disease I-ORG Research I-ORG Foundation I-ORG No. O 17DZ2260200 B-AWARD This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20170497 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M642332 O and O the O Practical B-ORG Innovation I-ORG Training I-ORG Plan I-ORG for I-ORG College I-ORG Students I-ORG in I-ORG Jiangsu I-ORG Province I-ORG 201811117003Z O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O STI2030-Major B-ORG Projects I-ORG 2021ZD0201003 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31830035 O 31771156 B-AWARD 21921004 B-AWARD 82151309 B-AWARD the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDB32030200 O the O Shenzhen B-ORG Key I-ORG Laboratory I-ORG of I-ORG Viral I-ORG Vectors I-ORG for I-ORG Biomedicine I-ORG ZDSYS20200811142401005 O and O the O Key B-ORG Laboratory I-ORG of I-ORG Quality I-ORG Control I-ORG Technology I-ORG for I-ORG Virus-Based I-ORG Therapeutics I-ORG Guangdong I-ORG Provincial I-ORG Medical I-ORG Products I-ORG Administration I-ORG 2022ZDZ13 O M.L O is O funded O by O a O research O grant O RH-0073-2021 B-AWARD from O Andalusian B-ORG Health I-ORG Department O L.F O has O received O funds O from O Sara B-ORG Borrell’s I-ORG postdoctoral I-ORG Fellowship I-ORG ISCIII O grant O code O CD20/00153 B-AWARD A.G.-M O is O funded O by O a O postdoctoral O grant O from O Economic B-ORG Change I-ORG Industry I-ORG Knowledge I-ORG and I-ORG Universities I-ORG Department I-ORG DOC_01677 O J.A.L.-E O and O L.F O also O received O funds O for O stem O cell O research O from O ibs.GRANADA B-ORG INTRAIBS-2021-07 O This O project O was O supported O by O the O network O “Bibliothèque O du I-ORG Vivant” O funded O by O the O CNRS-MNHN-INRA-CEA B-AWARD Genoscope O the O “Service O de I-ORG Systématique I-ORG Moléculaire” O UMS O 2700 I-AWARD CNRS-MNHN O the O deep-sea O studies O developed O in O the O French–Taiwanese B-ORG project I-ORG TF-DeepEvo I-ORG ANR-NSC I-ORG ANR O 12-ISV7-0005-01 O and O the O Russian B-ORG Science I-ORG Foundation I-ORG award O 16-14-10118 B-AWARD to I-AWARD YIK O LAG O received O a O PhD O studentship O from O FUNDAYACUCHO-Venezuela O and O Campus O France O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG Key I-ORG Industrial I-ORG Innovation I-ORG Project I-ORG Fund I-ORG 2023-ZDLSF-44 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Major I-ORG Research I-ORG Program I-ORG Integration I-ORG Project I-ORG 92259302 O and O the O Independent B-ORG Funds I-ORG of I-ORG the I-ORG Key I-ORG Laboratory I-ORG CBSKL2022ZZ34 O CBSKL2015Z12 B-AWARD China’s B-ORG ’Chang I-ORG Qing I-ORG Teng’ I-ORG Youth O Funding O 2022CQT O Shi O Yanting O This O work O was O supported O by O PNHRC B-ORG grant O PPRC2017-11-0029 B-AWARD TKA O KACST B-ORG GRANT I-ORG P-S-3812(HA O and O the O NIH B-ORG grant I-ORG DA029091 B-AWARD TAG O This O study O was O supported O by O the O Young B-ORG Scientists I-ORG Fund I-ORG of O the O National O Science O Foundation O of O China O 31501102 O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2017YFA0103800 O and O Beijing B-ORG Municipal I-ORG Science I-ORG I-ORG Technology I-ORG Commission I-ORG Z181100003818005 O This O research O was O supported O in O part O by O NIAMS/NIH B-ORG awards I-ORG R01AR068332 B-AWARD and O R01AR076477 B-AWARD both O to O U.S O funds O from O the O Indiana B-ORG Clinical I-ORG and I-ORG Translational I-ORG Sciences I-ORG Institute I-ORG funded O in O part O by O Grant O Number O UL1TR002529 B-AWARD from O the O NIH O National O Center O for O Advancing O Translational O Sciences O Clinical O and O Translational O Sciences O Award O to O U.S O and O J.C.T O and O Veterans B-ORG Research I-ORG Administration I-ORG Merit I-ORG Award O 1I0 B-AWARD 1BX005154 I-AWARD to O L.I.P O J.N.W O was O supported O through O a O Comprehensive B-ORG Musculoskeletal I-ORG T32 I-ORG Training I-ORG Program I-ORG from O NIAMS/NIH B-AWARD AR065971 O The O study O sponsors O were O not O involved O in O any O aspects O of O this O study O including O study O design O collection O analysis O and O interpretation O of O data O or O in O the O writing O of O the O manuscript O and O in O the O decision O to O submit O the O manuscript O for O publication O The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O NIH O or O the O VA. O This O work O was O supported O by O the O project-sponsored O by O SRF B-ORG for I-ORG ROCS I-ORG SEM I-ORG K513901814 O the O Soochow B-ORG University I-ORG high-level I-ORG scientific I-ORG research I-ORG foundation I-ORG for O the O introduction O talent O Q413900612 O Pre-research O foundation O for O nature O science O of O Soochow O University O Q313904713 O and O Research B-ORG foundation I-ORG for I-ORG the I-ORG prevention I-ORG medicine I-ORG in I-ORG Jiangsu I-ORG province I-ORG Y2012024 O This O work O was O supported O by O the O Public B-ORG Welfare I-ORG Technology I-ORG Application I-ORG Research I-ORG Plan I-ORG of I-ORG Zhejiang I-ORG Province O China O No. O 2017C33025 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81770645 O National B-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG China I-ORG No. O 2018260134 O Key B-ORG Research I-ORG I-ORG Development I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. O 2020C03057 O Medical B-ORG and I-ORG health I-ORG platform I-ORG project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. O 2020375961 O This O research O was O funded O by O the O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG LY19C030003 O Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG ZR2016CL05 O ZR201702160323 O and O Hubei B-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Basin I-ORG Water I-ORG Resources I-ORG and I-ORG Ecological I-ORG Environment I-ORG Sciences I-ORG CKWV2018492/KY O This O work O was O supported O by O Norway O through O the O Norwegian B-ORG Financial I-ORG Mechanism I-ORG grant O number O ALKEKONGE O PNRF-234-AI-1/07 B-AWARD the O Polish B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Higher I-ORG Education I-ORG grant O number O Iuventus O Plus O 0638/IP1/2013/72 B-AWARD to O KWJ O and O National B-ORG Science I-ORG Centre I-ORG Poland I-ORG no: O 2017/25/B/NZ8/01417 B-AWARD to O KWJ O This O work O was O supported O by O Special O Fund O for O Forest B-ORG Scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Welfare I-ORG 201404401 O We O were O also O supported O by O the O scientist B-ORG exchange I-ORG in I-ORG the I-ORG framework I-ORG of I-ORG the I-ORG cooperation I-ORG program I-ORG PPP I-ORG that O was O jointly O funded O by O the O CSC O and O DAAD O 2009-6037 O Chinese B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG 31500529 O and O the O BMBF-BEST B-ORG project I-ORG FKZ033L033A-E O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O current O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O No. O 31600969 B-AWARD 31771315 B-AWARD 81371284 B-AWARD 81570403 B-AWARD 81903590 B-AWARD and O U1732157 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Province I-ORG grant O No. O 1808085QH243 B-AWARD the O Science B-ORG Research I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Medical I-ORG University I-ORG grant O No.2017xkj001 O No. O 2017xkj006 O BSKY B-AWARD XJ201607 O the O National B-ORG Undergraduate I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Training I-ORG Program I-ORG grant O No. O 201810366019X B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG grant O No. O 2016A030313625 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Universidad O de O Antioquia O UdeA O CODI B-ORG UdeA I-ORG 2014-927 O Maria O Teresa O Rugeles O Lopez O Universidad B-ORG Cooperativa I-ORG de I-ORG Colombia I-ORG 1551-VS6 O Juan O Carlos O Hernandez O Corporación B-ORG Universitaria I-ORG Remington I-ORG I-ORG Uniremington I-ORG 4000000059-16 O Natalia O Andrea O Taborda O No O funding O bodies O had O any O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O by O Pudong B-ORG New I-ORG Area I-ORG Committee I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Grant O No. O PKJ2015-Y17 B-AWARD Important B-ORG Weak I-ORG Subject I-ORG Construction I-ORG Project I-ORG of I-ORG Pudong I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Grant O No. O PWZbr2017-09 B-AWARD and O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81571693 B-AWARD This O research O was O funded O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2022YFC2704303 O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O no. O 82203739 B-AWARD Joint B-ORG Funds I-ORG for I-ORG the I-ORG Innovation I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2020Y9160 O and O Fujian B-ORG Provincial I-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 2020J02059 O 2021J01404 B-AWARD and O 2021Y9157 B-AWARD This O study O was O supported O by O the O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG No. O 2015CB5540007 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81572413 B-AWARD the B-ORG Foundation I-ORG of I-ORG Independent I-ORG Innovation I-ORG Fund I-ORG of I-ORG Huazhong I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG No.2017KFYXJJ230 O and O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG No.2016CFA100 O and O No. O 2017CFB179 B-AWARD The O study O was O carried O out O with O the O main O financial O support O of O Russian B-ORG Science I-ORG Foundation I-ORG grant O 17-14-01063 B-AWARD with O the O partial O financial O support O of O Russian B-ORG Foundation I-ORG for I-ORG Basic I-ORG Research I-ORG grants O 16-34-00687 B-AWARD 16-34-60060 B-AWARD 17-34-50012 B-AWARD the O base O part O of O Goszadanie B-ORG project I-ORG 6.9654.2017/8.9 B-AWARD joint O program O of O DAAD B-ORG and I-ORG Ministry I-ORG of I-ORG education I-ORG and I-ORG Science I-ORG M. O Lomonosov O 6.12735.2018/12.2 O and O Lake B-ORG Baikal I-ORG Foundation I-ORG FOB_02-3/05 O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O National B-ORG Natural I-ORG Scientific I-ORG Foundation I-ORG of I-ORG China O 82074000 O 82073945 I-AWARD and I-AWARD 81874329 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2021YFA1301200 O and O the O Natural B-ORG Scientific I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG 2022JJ80112 O The O authors O Thank O for O financial O support O to O the O Ministry B-ORG of I-ORG Education I-ORG Youth I-ORG and I-ORG Sports I-ORG of I-ORG the I-ORG Czech I-ORG Republic I-ORG grant O O LM2015064 B-AWARD ERIC O to O the O National O Sustainability O Program O I O POLYMAT O LO1507 O Martin O Hrubý O and O Tomáš O Urbánek O thank O to O the O Czech B-ORG Science I-ORG Foundation I-ORG grant O O 18-07983S B-AWARD and O to O the O Academy B-ORG of I-ORG Sciences I-ORG of I-ORG the I-ORG Czech I-ORG Republic I-ORG mobility O grant O O DAAD-19-09 B-AWARD Eliézer O Jäger O and O Alessandro O Jäger O acknowledge O the O Czech O Science O Foundation O grant O O 17-09998S B-AWARD This O research O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Sichuan O China O No. O 2023NSFSC0234 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Chongqing O China O No. O CSTB2022NSCQ-MSX1602 B-AWARD and O Key B-ORG R&D I-ORG Program I-ORG Supported I-ORG by I-ORG the I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Gansu I-ORG Province I-ORG No. O 20YF8NA029 B-AWARD This O research O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31571838 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG LR17C200001 O National O Key O R&D O Program O of O China O 2017YFD0400200 O the B-ORG 111 I-ORG project I-ORG B17039 O and O the O Agricultural O Outstanding O Talents O and O Innovation O Team O of O the O State O Agricultural O Ministry O on O Health O and O Nutrition O of O Fruit O This O study O was O supported O by O Shanghai B-ORG Committee I-ORG of I-ORG Science I-ORG and I-ORG Technology O China O Grant O No. O 12DZ1940808 B-AWARD The B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81272401 B-AWARD and O The B-ORG International I-ORG Foundation I-ORG of I-ORG Translational I-ORG Medicine I-ORG for I-ORG Abroad I-ORG Scholars I-ORG and I-ORG Students I-ORG U.S I-ORG and I-ORG China I-ORG No. O UCTMP2015-03C001 B-AWARD This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2022YFD2400503 O Guangdong B-ORG Province I-ORG Strategic I-ORG projects I-ORG for I-ORG rural I-ORG revitalization I-ORG 2022-spy-00-009 O Key B-ORG Areas I-ORG of I-ORG Guangdong I-ORG Province I-ORG Research I-ORG and I-ORG Development I-ORG projects I-ORG 2021B0202020002 O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG 2023A1515030022 O Central B-ORG Public-Interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG of I-ORG CAFS I-ORG 2020TD21 O 2021TS03 B-AWARD Rural B-ORG Science I-ORG and I-ORG Technology I-ORG Correspondent I-ORG Fund I-ORG of I-ORG Guangzhou I-ORG 20212100051 O and O Guangzhou B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 202206010138 O Work O in O our O laboratory O is O funded O by O the O Medical B-ORG Research I-ORG Council O UK O grant O number O MR/N02589X/1 B-AWARD the O British B-ORG Heart I-ORG Foundation I-ORG grant O number O FS/14/43/30960 B-AWARD MKH O holds O a O University B-ORG College I-ORG London I-ORG Graduate B-AWARD Research I-AWARD Scholarship I-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82071171 O 81870815 B-AWARD Key B-ORG R&D I-ORG Program I-ORG of I-ORG Gansu I-ORG 21YF5FA165 O and O Open B-ORG Subject I-ORG Foundation I-ORG of I-ORG Peking I-ORG University I-ORG School I-ORG and I-ORG Hospital I-ORG of I-ORG Stomatology I-ORG PKUSS20210202 O This O work O is O supported O by O 111 B-ORG Project O grant O number O D23006 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 62272079 B-AWARD 61972266 B-AWARD Liaoning B-ORG Revitalization I-ORG Talents I-ORG Program O grant O number O XLYC2008017 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province O grant O number O 2021-MS-344 B-AWARD 2021-KF-11-03 B-AWARD 2022-KF-12-14 B-AWARD Postgraduate B-ORG Education I-ORG Reform I-ORG Project I-ORG of I-ORG Liaoning I-ORG Province O grant O number O LNYJG2022493 B-AWARD Dalian B-ORG Outstanding I-ORG Young I-ORG Science I-ORG and I-ORG Technology I-ORG Talent I-ORG Support I-ORG Program O grant O number O 2022RJ08 B-AWARD Funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61172108 B-AWARD to O TQ, O General B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Educational I-ORG Committee I-ORG L2014540 B-AWARD to O HL, O and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG DC201502060405 B-AWARD to O HL. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81700837 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG Project I-ORG No. O 14JJ3041 O and O Department B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Hunan I-ORG No. O 2015TP2007 O The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O received O financial O support O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. B-AWARD 2017YFD0501200 O the O Policy B-ORG Guidance I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG for I-ORG International I-ORG Scientific I-ORG and I-ORG Technological I-ORG Cooperation I-ORG Grant O No. B-AWARD BZ2019013 O and O the O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG 973 I-ORG Program I-ORG of I-ORG P.R I-ORG China I-ORG Grant O No. B-AWARD 2015CB150300 O This O work O was O founded O by O the B-ORG Health I-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG 201540415 O Shanghai B-ORG 3-Year I-ORG Public I-ORG Health I-ORG Action I-ORG Plan I-ORG GWTD2015S04 O and O Shanghai B-ORG Leading I-ORG Academic I-ORG Discipline I-ORG Project I-ORG of I-ORG Public I-ORG Health I-ORG 15GWZK80101 O The O sponsors O have O no O role O in O the O study O design O survey O process O data O analysis O and O manuscript O preparation O This O research O is O supported O by O the O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81570940 B-AWARD and I-AWARD 81873706 I-AWARD to O J.D O High-Level B-ORG Talents I-ORG of I-ORG the I-ORG Beijing I-ORG Health I-ORG System I-ORG 2014-3-077 O to O J.D O Beijing B-ORG Scholar I-ORG Program I-ORG PXM O 2013_014226_000055 I-AWARD PXM2015_014226_000116 I-AWARD PXM2015_014226_000055 I-AWARD PXM2015_014226_000052 I-AWARD to O S.W O This O work O was O supported O by O FONDECYT B-ORG 1140504 B-AWARD and O by O a O graduate O scholarships O CONICYT B-ORG 21110252 B-AWARD to O PC O and O MECESUP B-ORG 2-UCH0604 B-AWARD to O NB. O This O work O was O funded O by O the B-ORG camellia I-ORG research I-ORG project I-ORG of I-ORG Jiangxi I-ORG Forestry I-ORG Bureau I-ORG JXYCZX(2023)030201 O Jiangxi B-ORG Province I-ORG Major I-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG 20203ABC28W016 O the B-ORG Key I-ORG Projects I-ORG of I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG Jiangxi I-ORG Province I-ORG Grant O Number O 20192BBFL60014 B-AWARD the O earmarked O fund O for O Youthful O Innovation O Research O Team O of O Jiangxi O Agricultural O University-05 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Province I-ORG 20212BAB215012 O and O the O Special B-ORG Research I-ORG Project I-ORG on I-ORG Camphor I-ORG Tree I-ORG KRPCT I-ORG of I-ORG Jiangxi I-ORG Forestry I-ORG Department I-ORG 2020CXZX07 O This O research O was O supported O by O the O Spanish B-ORG Ministerio I-ORG de I-ORG Economía I-ORG y I-ORG Competitividad I-ORG CTQ2017-85093-P O Ministerio B-ORG de I-ORG Ciencia I-ORG Innovación I-ORG y I-ORG Universidades I-ORG RED2018-102387-T O PID2019-107268GB-100 B-AWARD and O the O University B-ORG of I-ORG Alicante I-ORG VIGROB-068 O This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81772950 B-AWARD to O RY O Q, O No. O 81502633 B-AWARD to O XL, O No. O 81773160 B-AWARD to O MW O HUBEI B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2017CFB467 O to O MW, O Wuhan B-ORG applied I-ORG basic I-ORG research I-ORG project I-ORG 2016060101010070 O to O RYQ O and O Tongji B-ORG Hospital I-ORG Science I-ORG Fund I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG 2016YQ08 O to O MW. O This O work O was O supported O by O the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG (CARS-4 O Guangdong B-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Animal I-ORG Molecular I-ORG Design I-ORG and I-ORG Precise I-ORG Breeding I-ORG 2019B030301010 O Engineering B-ORG Centre I-ORG of I-ORG Chicken I-ORG Breeding I-ORG in I-ORG Guangdong I-ORG Prov I-ORG 2017-1649 O Innovative B-ORG Research I-ORG Group I-ORG Project I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG CN) O 31601936 O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 42107430 O Jiangsu B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG BK20200547 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG KYQN2022029 O and O Jiangsu B-ORG Provincial I-ORG Double-Innovation I-ORG Doctor I-ORG Program I-ORG JSSCBS20210294 O This O work O was O supported O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2020YFA0113003 O Key B-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. O 2023C03046 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 2022ZFJH003 B-AWARD and O Research B-ORG Project I-ORG of I-ORG the I-ORG Jinan I-ORG Microecological I-ORG Biomedicine I-ORG Shandong I-ORG Laboratory I-ORG Nos O JNL-2022026C B-AWARD and O JNL-2023003C B-AWARD This O work O was O funded O by O the O US O National B-ORG Science I-ORG Foundation I-ORG DMR-BMART-1206908 O the O U.S B-ORG Department I-ORG of I-ORG Energy I-ORG Great O Lakes O Bioenergy O Research O Center O DOE O Office O of O Science O BER O DE-FC02-07ER64494 B-AWARD and O Office O of O Biological B-ORG and I-ORG Environmental I-ORG Research I-ORG DE-SC0012411 O Additional O funding O was O provided O by O grant O DE-FG02-91ER200021 B-AWARD to O the O MSU-DOE O Plant O Research O Laboratory O from O the O U.S O Department O of O Energy O Office O of O Basic O Energy O Sciences O Division O of O Chemical O Sciences O Geosciences O and O Biosciences O This O work O was O supported O by O the O NSFC-Shandong B-ORG Joint I-ORG Fund I-ORG No. O U1806213 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2021QD082 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 42176154 B-AWARD This O work O was O supported O Grant-in-Aid B-ORG for I-ORG Scientific I-ORG Research I-ORG C) O No. O 26440207 B-AWARD to O MY O http://www.um.u-tokyo.ac.jp/people/faculty_yago.html O This O funder O provided O the O idea O fund O and O resources O and O participated O writing O original O draft O and O revision O This O work O was O also O supported O by O the O Chinese B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 40971037 B-AWARD to O MW O This O funder O provided O the O idea O fund O resource O and O participated O filed O survey O confirmed O test O Lastly O it O was O funded O by O the O CSC O China O Scholarship I-ORG Council O Liujinfa B-AWARD 2015 I-AWARD 3022 I-AWARD to O HZ. O This O funder O conducted O almost O all O aspects O of O this O research O expect O resources O and O validation O This O research O was O funded O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O number O 2016YFB0302000 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of O China O Grant O number O 2019MS062 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O number O 51803029 B-AWARD Australian O Research O Council O Discovery O Early O Career O Research O Award O Grant O number O DE190101176 O Australian O Research O Council O Industrial O Training O Transformation O Centre O Grant O number O IC170100032 O and O City B-ORG University I-ORG of I-ORG Hong I-ORG Kong I-ORG Grant O number O 9678103 B-AWARD This O work O was O supported O by O CANARIE O Compute O Canada O and O Genome O Canada O Additional O support O came O from O a O grant O from O the O National B-ORG Sciences I-ORG and I-ORG Engineering I-ORG Research I-ORG Council I-ORG NSERC-448167-2013 O and O a O grant O from O the O Canadian B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG CIHR-MOP-115090 O G.B O is O also O supported O by O the O Fonds B-ORG de I-ORG Recherche I-ORG Santé I-ORG Québec O FRSQ-25348 O This O research O was O funded O by O the O National B-ORG Key I-ORG R I-ORG I-ORG D I-ORG Program I-ORG of I-ORG China I-ORG 2021YFC2802203 O the O NSFC B-ORG U1939207 O the O Scientific B-ORG Instrument I-ORG Developing I-ORG Project I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG YJKYYQ20210036 O the O Youth B-ORG Innovation I-ORG Promotion I-ORG Association I-ORG of I-ORG CAS I-ORG 2022110 O and O the O Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG JCYJ20190814110601663 O This O study O was O supported O by O research O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41276138 O National B-ORG Marine I-ORG Public I-ORG Welfare I-ORG Research I-ORG Program I-ORG 201305005 O and O Doctoral B-ORG Program I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG 20130132110009 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O “National O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China” O No.81372734 O to O YYW O “Special O Foundation I-ORG of I-ORG Fujian I-ORG Medical I-ORG University I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Development” O No.FZS13035Y O to O YYW O “Trained O Foundation I-ORG of I-ORG Fujian I-ORG Provincial I-ORG Health I-ORG Family I-ORG Planning I-ORG Commission I-ORG for I-ORG the I-ORG Young I-ORG and I-ORG Middle-aged I-ORG Core I-ORG Talent” O No.2014-ZQN-ZD-30 O to O YYW O and O “Natural O Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG China” O No.2014J01440 O to O YYW O which O provided O funds O for O our O research O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O nos O 21773020 B-AWARD 21673026 B-AWARD and O 11505019 B-AWARD the O Liaoning B-ORG Innovative I-ORG Talents I-ORG in I-ORG University I-ORG grant O no. O LR2017025 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province I-ORG grant O no. O 20180550085 B-AWARD This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31701738 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Research I-ORG Project I-ORG of I-ORG Education I-ORG Department I-ORG of I-ORG Liaoning I-ORG No. O LSNYB201614 B-AWARD the O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG No. O 2013CB127701 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2018YFA0900100 O the O National B-ORG Natural I-ORG Science I-ORG Funding I-ORG of I-ORG China I-ORG 31570035 O and O 31670093 B-AWARD and O the B-ORG Tianjin I-ORG Natural I-ORG Science I-ORG Funding I-ORG 17JCZDJC32100 O and O 18JCYBJC24500 B-AWARD The O research O leading O to O these O results O has O received O funding O from O FAR B-AWARD 2017–2021 O Fondazione B-ORG Gigi I-ORG and I-ORG Pupa I-ORG Ferrari I-ORG Onlus O and O from O Research O funded O by O Regione B-ORG Lombardia I-ORG regional I-ORG law I-ORG n° O 9/2020 B-AWARD resolution O n° O 3776/2020 B-AWARD Programma B-ORG degli I-ORG interventi I-ORG per I-ORG la I-ORG ripresa I-ORG economica I-ORG sviluppo I-ORG di I-ORG nuovi I-ORG accordi I-ORG di I-ORG collaborazione I-ORG con I-ORG le I-ORG università I-ORG per I-ORG la I-ORG Ricerca I-ORG l’Innovazione I-ORG e I-ORG il I-ORG Trasferimento I-ORG tecnologico I-ORG NephropaThy I-ORG This O work O was O supported O by O Key B-ORG Technologies I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Tianjin I-ORG 16YFZCSY00770 O Innovation B-ORG Fund I-ORG for I-ORG Youth I-ORG of I-ORG Tianjin I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2015LG19 O and O Tianjin B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG 15JCTPJC62800 O All O the O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Collaborative B-ORG Innovation I-ORG Project I-ORG from I-ORG the I-ORG People’s I-ORG Government I-ORG of I-ORG Fujian I-ORG Province I-ORG I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG XTCXGC2021006 O the O Project B-ORG of I-ORG Fujian I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG CXTD2021009-2 O the O Project B-ORG of I-ORG Construction I-ORG of I-ORG Deciduous I-ORG Fruit I-ORG Tree I-ORG Germplasm I-ORG Resource I-ORG Nursery I-ORG of I-ORG Fujian I-ORG ZYBHDWZX202206 O and O the O Project B-ORG of I-ORG Seed I-ORG Industry I-ORG Innovation I-ORG and I-ORG Industrialization I-ORG of I-ORG Fujian I-ORG zycxny2021010-3 O The O collaborative O funding O supported O by O Opening B-ORG Project I-ORG Fund I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Mining I-ORG Disaster I-ORG Prevention I-ORG and I-ORG Control I-ORG Co-founded I-ORG by I-ORG Shandong I-ORG Province I-ORG and I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG No. O MDPC2013ZR03 B-AWARD the O funding O supported O by O Scientific B-ORG Research I-ORG Foundation I-ORG of I-ORG Shandong I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG for I-ORG Recruited I-ORG Talents I-ORG No. O 2014RCJJ027 B-AWARD and O the O funding O by O Shandong B-ORG Province I-ORG Higher I-ORG Educational I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG A1042420161008 O The O Undergraduate O Research O for O Creative O Activates O grant O supported O AJM O and O AG, O and O the O National B-ORG Science I-ORG Foundation I-ORG Postdoctoral O Fellowship O 1611692 O supported O GVD O UCSB B-ORG faculty I-ORG research I-ORG grant I-ORG 8‐580611‐19941‐7 B-AWARD was O awarded O to O CJB O SM, O and O RC. O This O research O was O supported O in O part O by O a O National B-ORG Science I-ORG Foundation I-ORG Graduate I-ORG Research I-ORG Fellowship I-ORG to O K. O Ibsen O under O Grant O No. O DGE-1144085 B-AWARD This O work O was O also O supported O by O a O grant O to O the O MRL O Shared O Experimental O Facilities O supported O by O the O MRSEC O Program O of O the O NSF O under O Award O No. O DMR O 1121053 O a O member O of O the O NSF-funded O Materials O Research O Facilities O Network O Duncan O and O Suzanne O Mellichamp O also O provided O support O This O study O was O funded O by O the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG Grant O CARS-36 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31430066 B-AWARD Major B-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG 2015ZDJS04002 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O numbers O 51875455 B-AWARD and O 62075180 B-AWARD the O Shaanxi B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Plan O grant O number O 2023-YBGY-400 B-AWARD and O the O Xi’an B-ORG Science I-ORG and I-ORG Technology I-ORG Plan O grant O number O 22GXFW0089 B-AWARD This O study O was O supported O by O the O “Development O of O Diagnostic O Technology O for O Detection O of O miRNA O in O Body O Fluids” O grant O from O the O Japan B-ORG Agency I-ORG for I-ORG Medical I-ORG Research I-ORG and I-ORG Development I-ORG and I-ORG New I-ORG Energy I-ORG and I-ORG Industrial I-ORG Technology I-ORG Development I-ORG Organization I-ORG to O S.N O grant O number O JP17ae0101013 B-AWARD This O work O was O also O partially O supported O by O Core O Research O for O Evolutional O Science O and O Technology O grant O from O the O Japan B-ORG Science I-ORG and I-ORG Technology I-ORG Agency I-ORG grant O number O JPMJCR1412 B-AWARD Japan B-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG KAKENHI I-ORG grant O numbers O 17H06307 B-AWARD and I-AWARD 17H06299 O the O Japan O Foundation O for O Aging O and O Health O and O the O Takeda O Science O Foundation O The O funding O bodies O played O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O No. B-AWARD 2016YFA0602500 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O 41371170 B-AWARD and O Key B-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shandong I-ORG grant O 2017GSF22102 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFF0215200 O and O 2017YFF0211201 B-AWARD Science B-ORG I-ORG Technology I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Quality I-ORG and I-ORG Technical I-ORG Supervision I-ORG Bureau I-ORG KJ185613 O Science B-ORG I-ORG Technology I-ORG Project I-ORG of I-ORG China I-ORG General I-ORG Administration I-ORG of I-ORG Quality I-ORG Supervision I-ORG Inspection I-ORG and I-ORG Quarantine I-ORG 2015QK055 O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Nanjing I-ORG China I-ORG 201716005 O This O work O was O supported O by O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Hainan I-ORG Province I-ORG 20163111 O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31572087 O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG of I-ORG China I-ORG 2014A030307031 O the B-ORG Basic I-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG Non-profit I-ORG Central I-ORG Research I-ORG Institutions I-ORG No. O 1630062015004 B-AWARD the B-ORG Germplasm I-ORG Resource I-ORG Protection I-ORG of I-ORG Ministry I-ORG of I-ORG Agriculture I-ORG 2016NWB053 O the O Germplasm I-ORG Resource I-ORG Protection I-ORG of I-ORG Ministry I-ORG of I-ORG Agriculture I-ORG Wild I-ORG Plant I-ORG 1251416305010 O the B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2016A020208002 O and O the B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Province I-ORG grant O no. O 1408085MKL63 B-AWARD This O work O was O funded O by O Shandong B-ORG Province I-ORG Medical I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Project I-ORG of O China O No. O 2016WS0045 B-AWARD Shandong B-ORG Province I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG No. O 2016GSF201021 B-AWARD and O Shandong B-ORG Province I-ORG Higher I-ORG Educational I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG No. O J16LL01 B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81460579 O the O Science B-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Guizhou I-ORG Province I-ORG QKHSY[2015]3030 O and O Graduate B-ORG Student I-ORG Work I-ORG Station I-ORG Project I-ORG of I-ORG Guizhou I-ORG Province I-ORG JYSZ O 2014]016 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG under O grant O No. O 2016YFB0201305 B-AWARD the O Shenzhen B-ORG Basic I-ORG Research I-ORG Fund I-ORG under O grant O no. O JCYJ20160331190123578 B-AWARD JCYJ20170818164014753 I-AWARD JCYJ20170413093358429 I-AWARD and I-AWARD GGFW2017073114031767 O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O grant O no. O U1435215 B-AWARD and I-AWARD 61433012 O the O National B-ORG Natural I-ORG Youth I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 31601028 B-AWARD and O the O Nature B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG grant O no. O 2017A030313144 B-AWARD We O also O received O funding O support O from O the O Shenzhen O Discipline O Construction O Project O for O Urban O Computing O and O Data O Intelligence O Youth O Innovation O Promotion O Association O CAS O to O Yanjie O Wei O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 31670355 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG of I-ORG Shandong I-ORG Province O grant O number O JQ201712 B-AWARD Key O Cutting-Edge O Research O Program O of O the O CAS O grant O number O QYZDB-SSW-DQC013 B-AWARD the O Science O and O Technology O Service O Network O Initiative O of O the O CAS O grant O number O KFJ-STS-ZDTP-023 B-AWARD and O the O Youth B-ORG Innovation I-ORG Promotion I-ORG Association I-ORG of I-ORG the I-ORG CAS O grant O number O 2013138 B-AWARD SMIR O is O wholly O commissioned O and O funded O by O the O Ministry O of O Health O Singapore O as O part O of O the O National O Registry O of O Diseases O Office O Dr O Chan O is O supported O by O a O Clinician-Scientist O award O from O the O National B-ORG Medical I-ORG Research I-ORG Council O Singapore O NMRC/CSA/028/2011 O and O Dr O Richards O is O supported O by O a O Singapore O Translational O Research O Investigator O award O NMRC/STaR/0022/2014 O The O funding O organization O for O this O study O was O not O involved O in O the O design O and O conduct O of O the O study O or O approval O of O the O article O for O publication O Dr O Hausenloy O was O supported O by O the O British B-ORG Heart I-ORG Foundation I-ORG CS/14/3/31002 O the O National O Institute O for O Health O Research O University O College O London O Hospitals O Biomedical O Research O Centre O Duke-National O University O Singapore O Medical O School O Singapore O Ministry O of O Health’s O National O Medical O Research O Council O under O its O Clinician O Scientist-Senior O Investigator O scheme O NMRC/CSA-SI/0011/2017 O and O Collaborative O Centre O Grant O scheme O NMRC/CGAug16C006 O and O the O Singapore O Ministry O of O Education O Academic O Research O Fund O Tier O 2 O MOE2016-T2-2-021 O This O article O is O based O upon O work O from O COST O Action O EU-CARDIOPROTECTION B-AWARD CA16225 I-AWARD supported O by O COST O European O Cooperation I-ORG in I-ORG Science I-ORG and I-ORG Technology O This O work O was O supported O by O grants O for O the B-ORG National I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 O Program O 2007CB815700 B-AWARD and O 2007CB411600 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 30760038 O and O 31301014 B-AWARD the B-ORG Eleventh I-ORG Five-year I-ORG Plan I-ORG of I-ORG Country I-ORG Technology I-ORG Pedestal I-ORG 2006BAD13B08 O and O the B-ORG Technology I-ORG Resources I-ORG Platform I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2005DKA21101 O This O study O was O financially O supported O by O the O Scientific O research O start-up O funds O for O openly-recuited O doctors O of O Gansu O Agricultural O University O GAU-KYQD-2019-17 O the O Utilization B-ORG Technology I-ORG of I-ORG Rapeseed I-ORG Heterosis I-ORG and I-ORG Creation I-ORG of I-ORG Strong I-ORG Heterosis I-ORG of I-ORG China I-ORG 2016YFD0101300 O Agriculture B-ORG Research I-ORG System I-ORG of I-ORG China I-ORG CARS-12 O and O the B-ORG Agriculture I-ORG Research I-ORG System I-ORG of I-ORG Gansu I-ORG Province I-ORG GARS-TSZ-1 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31860388 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O in O part O by O grants O awarded O to O F.O.G O by; O Enterprise B-ORG Ireland I-ORG CF-2017-0757-P O the O European B-ORG Commission I-ORG FP7-PEOPLE-2013-ITN O 607786 O FP7-KBBE-2012-6 B-AWARD CP-TP-312184 O FP7-KBBE-2012-6 B-AWARD 311975 O OCEAN B-AWARD 2011-2 I-AWARD 287589 O EU2020-634486-2015 B-AWARD Science B-ORG Foundation I-ORG Ireland I-ORG SSPC-2 O 12/RC/2275 O 13/TIDA/B2625 B-AWARD 12/TIDA/B2411 B-AWARD 12/TIDA/B2405 B-AWARD 14/TIDA/2438 B-AWARD 15/TIDA/2977 B-AWARD the O Department B-ORG of I-ORG Agriculture I-ORG and I-ORG Food I-ORG FIRM O 1/F009/MabS O FIRM B-AWARD 13/F/516 O the O Irish B-ORG Research I-ORG Council I-ORG for I-ORG Science I-ORG Engineering I-ORG and I-ORG Technology I-ORG GOIPG/2014/647 O the O Health B-ORG Research I-ORG Board/Irish O Thoracic O Society O MRCG-2014-6 O U1404316 B-AWARD was O granted O by O National O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O http://www.nsfc.gov.cn O to O YFY O Yuafeng O Yang O CARS-11-C-14 B-AWARD was O granted O by O Earmarked O Fund I-ORG for I-ORG China I-ORG Agriculture I-ORG Research I-ORG System O http://119.253.58.231 O to O GHY O Guohong O Yang O 2015ZZ09 B-AWARD was O granted O by O Independent O Innovation I-ORG Fund I-ORG of I-ORG Henan I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences"(http://www.hnagri.org.cn O to O YFY O Yufeng O Yang O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81874183 I-AWARD 81872304 I-AWARD and I-AWARD 81672845 O the B-ORG Jiangsu I-ORG Provincial I-ORG Key I-ORG Medical I-ORG Discipline O and O the B-ORG Project I-ORG of I-ORG Invigorating I-ORG Health I-ORG Care I-ORG through I-ORG Science I-ORG Technology I-ORG and I-ORG Education I-ORG NO. O ZDXKA2016014 O ZDRCC2016009 B-AWARD and O the O Qing O Lan O Project O This O manuscript O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangxi I-ORG 2018GXNSFBA281159 O Youth B-ORG Foundation I-ORG of I-ORG Guangxi I-ORG Medical I-ORG University I-ORG GXMUYSF201506 O and O Youth B-ORG Teacher I-ORG Foundation I-ORG of I-ORG Guangxi I-ORG Education I-ORG Department I-ORG 2017KY0110 O This O work O was O financially O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 51601099 B-AWARD and O Grant O No. O 51861029 B-AWARD Program O for O Young O Talents O of O Science O and O Technology O in O Universities O of O Inner O Mongolia O Autonomous O Region O Foundation B-ORG of I-ORG Inner I-ORG Mongolia I-ORG University I-ORG of I-ORG Technology O Grant O No. O ZD201607 B-AWARD Ningbo B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2018A610061 O Scientific O Research O Foundation O of O The O Higher O Education O Institutions O SRFHEI O of O Inner O Mongolia O Autonomous O Region O of O China O Grant O No. O NJZY18096 B-AWARD and O the O project O is O supported O by O Inner O Mongolia O Science O O Technology O Plan O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O U1909217 B-AWARD the O Zhejiang B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O LD21E050001 B-AWARD and O the O Wenzhou B-ORG Major I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG China I-ORG Nos O ZG2021019 B-AWARD ZG2021027 B-AWARD the O IUI B-ORG Cooperation I-ORG Project I-ORG of I-ORG Zhuhai I-ORG No. O ZH22017001210104PWC B-AWARD This O work O was O supported O by O the O Beijing B-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Grant O Z151100004015172 B-AWARD Beijing B-ORG Natural I-ORG Science I-ORG Fund I-ORG 7132087 O Public B-ORG Health I-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Committee I-ORG of I-ORG the I-ORG Beijing I-ORG Municipal I-ORG Development I-ORG projects I-ORG Z131100006813041 O and O the O Medical B-ORG Development I-ORG Research I-ORG Foundation I-ORG of I-ORG the I-ORG Capital I-ORG China I-ORG Grant O 2014-4-2025 B-AWARD This O study O was O funded O by O a O Top O Talent O grant O of O the O Donders O Institute O for O Brain O Cognition O and O Behaviour O In O addition O the O research O leading O to O these O results O has O received O funding O from O the O European B-ORG Community’s I-ORG Seventh I-ORG Framework I-ORG Programme I-ORG FP7/2007–2013 O under O Grant O agreements O no. O 603016 B-AWARD MATRICS O no. O 278948 B-AWARD TACTICS O no. O 602805 B-AWARD Aggressotype O and O from O the O Innovative B-ORG Medicines I-ORG Initiative I-ORG 2 I-ORG Joint I-ORG Undertaking I-ORG under O grant O agreement O no. O 115916 B-AWARD PRISM O This O Joint O Undertaking O receives O support O from O the O European O Union’s O Horizon O 2020 O research O and O innovation O programme O and O EFPIA O This O work O is O financially O supported O by O the O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG 2015CB910700 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grants O No. O 81402853 B-AWARD the O Hunan B-ORG Provincial I-ORG Innovation I-ORG Foundation I-ORG for I-ORG Postgraduate I-ORG CX2016B058 O the O Project O of O Innovation-driven O Plan O in O Central O South O University O and O the O Postdoctoral O Science O Foundation O of O Central O South O University O the O Chinese O Postdoctoral O Science O Foundation O 2014T70794 O 2014M562142 O The O studies O meet O with O the O approval O of O the O university’s O review O board O This O work O was O supported O by O grants O from O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC1313300 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017A030313485 O 2014A030312015 O and O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangdong I-ORG 2019B020227002 O This O study O was O supported O by O research O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81371858 O to O YJ O the O 973 B-ORG Preliminary I-ORG Research I-ORG Program I-ORG 2014CB560707 O to O YY O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG LQY18H190001 O to O JW O and O Zhejiang B-ORG Provincial I-ORG Medical I-ORG and I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG 2017KY125 O to O JW O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Province I-ORG Grant O No. O 20192BAB205053 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Research I-ORG Project I-ORG of I-ORG Jiangxi I-ORG Education I-ORG Department I-ORG Grant O No. O GJJ12561 B-AWARD Scientific B-ORG Research I-ORG Project I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG Bureau I-ORG of I-ORG Jiangxi I-ORG Grant O No. O 2018B161 B-AWARD and O Health B-ORG and I-ORG Planning I-ORG Commission I-ORG Research I-ORG Project I-ORG of I-ORG Ganzhou I-ORG Grant O No. O 2018-2-32 B-AWARD This O work O was O supported O by O the O Austrian B-ORG Science I-ORG Fund I-ORG FWF I-ORG in O the O framework O of O Research O Project O P26729-N19 B-AWARD Funding O for O this O work O has O also O been O provided O by O the O European B-ORG Research I-ORG Council I-ORG under O ERC O Grant O Agreement O No. O 340185 B-AWARD USMS O We O kindly O acknowledge O financial O support O by O the O Austrian B-ORG Research I-ORG Promotion I-ORG Agency I-ORG FFG O in O the O project O 3DnanoAnalytics O FFG-No O 858040 B-AWARD This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81970716 O and O No. O 81800720 B-AWARD Cultivation B-ORG Project I-ORG of I-ORG Clinical I-ORG Research I-ORG of I-ORG Shanghai I-ORG Hospital I-ORG Development I-ORG Center I-ORG SHDC12018X04 O Funding B-ORG from I-ORG Huashan I-ORG Hospital I-ORG North I-ORG Affiliated I-ORG to I-ORG Fudan I-ORG University I-ORG HSBY2016004 O and O Shanghai B-ORG general I-ORG hospital I-ORG integrated I-ORG traditional I-ORG Chinese I-ORG and I-ORG western I-ORG medicine I-ORG special I-ORG project I-ORG under O Grant O ZHYY-ZXYJHZX-1-01 O This O research O was O funded O by O Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG No. O 19441909600 O the B-ORG Opening I-ORG project I-ORG of I-ORG Shanghai I-ORG Key I-ORG Laboratory I-ORG of I-ORG Orthopedic I-ORG Implant I-ORG KFKT2019001 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 52275146 B-AWARD 21404038 B-AWARD This O work O was O supported O by O the O Grant B-ORG Agency I-ORG of I-ORG the I-ORG Czech I-ORG Republic I-ORG Grant O nos O 19-05608S B-AWARD and O 18-19714S B-AWARD by O the O Czech B-ORG Academy I-ORG of I-ORG Sciences I-ORG Grant O no. O JSPS-20-06 B-AWARD by O the O Institutional B-ORG Research I-ORG Concept I-ORG of I-ORG the I-ORG Institute I-ORG of I-ORG Molecular I-ORG Genetics I-ORG Grant O no. O RVO O 68378050 B-AWARD by O the O MEYS B-ORG CR I-ORG COST O Inter-Excellence O Internship O LTC19048 B-AWARD and O LTC20024 B-AWARD and O the O project O “BIOCEV—Biotechnology B-ORG and I-ORG Biomedicine I-ORG Centre I-ORG of I-ORG the I-ORG Academy I-ORG of I-ORG Sciences I-ORG and I-ORG Charles I-ORG University” I-ORG CZ.1.05/1.1.00/02.0109 O from O the O European B-ORG Regional I-ORG Development I-ORG Fund O COST B-ORG Pan-European I-ORG Network I-ORG in I-ORG Lipidomics I-ORG and I-ORG Epilipidomics I-ORG EpiLipidNET O CA19105 B-AWARD action O The O Microscopy O Centre O was O supported O by O the O MEYS O CR O LM2018129 O Czech-BioImaging O and O by O the O European O Regional O Development O Fund—Project O “Modernization O and O support O of O research O activities O of O the O national O infrastructure O for O biological O and O medical O imaging O CzechBioImaging” O no. O CZ.02.1.01/0.0/0.0/16_013/0001775 B-AWARD The O current O study O was O supported O by O funds O from O the B-ORG Promoting I-ORG Project I-ORG of I-ORG Basic I-ORG Capacity I-ORG for I-ORG Young I-ORG and I-ORG Middle-aged I-ORG University I-ORG Teachers I-ORG in I-ORG Guangxi I-ORG KY2016YB077 O the B-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG the I-ORG Guangxi I-ORG Education I-ORG Agency I-ORG KY2015LX062 O and O the B-ORG Guangxi I-ORG Zhuang I-ORG Autonomous I-ORG Region I-ORG University I-ORG Student I-ORG Innovative I-ORG Plan I-ORG 201710598080 O The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O São B-ORG Paulo I-ORG Research I-ORG Foundation I-ORG FAPESP O grant O numbers O 17/17728-8 B-AWARD and O 20/05202-4 B-AWARD the O Coordination B-ORG of I-ORG Superior I-ORG Level I-ORG Staff I-ORG Improvement I-ORG CAPES O grant O number O 88887.602617/2021-0 B-AWARD and O the O National B-ORG Council I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Development I-ORG CNPq O grant O numbers O 303408/2018-9 B-AWARD and O 402440/2021-8 B-AWARD This O study O was O supported O by O the O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O LD21C030001 B-AWARD Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 2021YFE0112000 B-AWARD and O National O Natural O Science O Foundation O of O China O Grant O No. O 31970219 B-AWARD to O R.L O Open B-ORG Funding I-ORG Project I-ORG of I-ORG the I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Biocatalysis I-ORG and I-ORG Enzyme I-ORG Engineering O Grant O No. O SKLBEE2021006 B-AWARD to O H.Z O Supported O by O a O grant O from O NWO B-ORG Netherlands O Organization O for O Scientific O Research O grant O 451-10-013 B-AWARD to O TCWN O and O by O the O EXPLICIT-stroke O grant O of O ZonMw B-ORG grant O 89000001 B-AWARD and O 4D-EEG O ERC O advanced I-ORG grant I-ORG 291339-4D-EEG B-AWARD to O GK. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O physical O part O of O the O research O was O funded O by O The B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Higher I-ORG Education I-ORG of I-ORG the I-ORG Russian I-ORG Federation I-ORG State O Assignment O No. O 075-01129-23-00 B-AWARD The O work O with O reprogrammed O cells O was O funded O by O the O Federal B-ORG Medical I-ORG and I-ORG Biological I-ORG Agency I-ORG of I-ORG Russia I-ORG project O “Reprogramming-1” O State O assignment O No. O 20.003.22.800 B-AWARD The O part O of O the O work O with O intravital O confocal O microscopy O was O supported O by O the O Russian B-ORG Scientific I-ORG Foundation I-ORG project O No. O 21-74-20110 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81772526 B-AWARD Shanghai B-ORG Municipal I-ORG Education I-ORG Commission-Gaofeng I-ORG Clinical I-ORG Medicine I-ORG Grant I-ORG Support I-ORG 20161425 O Shanghai B-ORG Jiaotong I-ORG University I-ORG Medical I-ORG Cross I-ORG Fund I-ORG YG2017MS28 O Shanghai B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Committee I-ORG 14411966800 O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG Project I-ORG of I-ORG Songjiang I-ORG District I-ORG 18SJKJGG23 O and O 19SJKJGG22 B-AWARD No O funders O have O any O roles O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 82260535 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Cultivation I-ORG Project I-ORG of I-ORG General I-ORG Program I-ORG of I-ORG Guizhou I-ORG Medical I-ORG University I-ORG No. O gyfynsfc-2022-07 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC I-ORG Cultivation I-ORG Program I-ORG of I-ORG Affiliated I-ORG Hospital I-ORG of I-ORG Guizhou I-ORG Medical I-ORG University I-ORG No. O gyfynsfc-2021-34 B-AWARD This O research O was O supported O by O the O National B-ORG Key I-ORG Technologies I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2012BAD12B02 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31472122 O and O the O Program B-ORG of I-ORG International I-ORG S&T I-ORG Cooperation I-ORG China I-ORG 2010DFB34230 O All O the O fundings O were O received O by O Junhu O Yao O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81702087 O Shenzhen B-ORG Scientific I-ORG and I-ORG Technological I-ORG Foundation I-ORG JCYJ20160427152933037 O JCYJ20160427152241973 O and O Shenzhen B-ORG Healthcare I-ORG Research I-ORG Project I-ORG 201605010 O The O funders O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O is O supported O by O operating O grants O to O LAS O from O the O Natural B-ORG Sciences I-ORG and I-ORG Engineering I-ORG Research I-ORG Council I-ORG of I-ORG Canada I-ORG NSERC O RGPIN-2017-03889 B-AWARD the O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG CIHR O MOP142215 B-AWARD The O Scottish B-ORG Rite I-ORG Charitable I-ORG Foundation I-ORG of I-ORG Canada I-ORG 15118 O and O the O University O of O Victoria O Division O of O Medical O Sciences O This O project O is O also O funded O through O CIHR O Bridge O Funding O PJT-153392 O awarded O to O LTA O and O LAS O CSWC O and O JCSA O were O supported O by O University O of O Victoria O Fellowship O Graduate O Awards O GWZ O is O supported O by O NSERC O and O holds O a O Canada O Research O Chair O LAS O is O supported O by O a O Michael B-ORG Smith I-ORG Foundation I-ORG for I-ORG Health I-ORG Research I-ORG and O a O British O Columbia O Schizophrenia O Society O Foundation O Scholar O Award O 5900 O Slovenian B-ORG Research I-ORG Agency O P1-0175 B-AWARD P1-0207 B-AWARD P4-0053 B-AWARD Universidad B-ORG Nacional I-ORG de I-ORG La I-ORG Plata I-ORG UNLP O GrantX053 B-AWARD Consejo B-ORG Nacional I-ORG de I-ORG Investigaciones I-ORG Científicas I-ORG y I-ORG Técnicas I-ORG CONICET O PIP B-AWARD 2051 O Agencia B-ORG Nacional I-ORG de I-ORG Promoción I-ORG Científica I-ORG y I-ORG Tecnológica I-ORG ANPCyT O PICT B-AWARD 2019-2322 I-AWARD This O work O was O supported O by O the O Capital B-ORG Health I-ORG Development I-ORG Fund I-ORG 201614035 O CAMS B-ORG Major I-ORG Collaborative I-ORG Innovation I-ORG Project I-ORG 2016-I2M-1-011 O and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 3332019135 O This O study O was O supported O by O the O Spanish B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Innovation I-ORG grant O number O FPU19/02117 B-AWARD S.L.-O O and O FPU20/07594 B-AWARD S.P.-G O and O by O grants O from O the O Spanish B-ORG Ministry I-ORG of I-ORG Economy I-ORG and I-ORG Competitiveness I-ORG and I-ORG Fondos I-ORG FEDER I-ORG Fondo O de O Investigaciones O Sanitarias O FIS O grant O number O PI18/00139 B-AWARD A.L O and O the O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III I-ORG postdoctoral O contract O Sara O Borrell O grant O number O CD21/00138 B-AWARD P.L.V. O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31300342 O and I-AWARD 31570417 O Anhui B-ORG Provincial I-ORG National I-ORG Science I-ORG Foundation I-ORG 1608085MC63 O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG and I-ORG Chinese I-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2014M561683 O SV O is O supported O by O a O postdoctoral O contract O at O Universidad O de O Alcalá O in O Madrid O Spain O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31672215 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0200900 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG China I-ORG 2662017QD039 O and I-AWARD 2662019PY013 O This O work O was O supported O by O the B-ORG Strategic I-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG No. O XDA11030201 B-AWARD the B-ORG National I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 I-ORG Program I-ORG No. O 2015CB755902 O the B-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG Project I-ORG Financially I-ORG Supported I-ORG by I-ORG Qingdao I-ORG National I-ORG Laboratory I-ORG for I-ORG Marine I-ORG Science I-ORG and I-ORG Technology I-ORG No. O 2016ASKJ14 O and O the B-ORG China I-ORG Scholarship I-ORG Council I-ORG CSC O No. B-AWARD 201604910395 O This O research O was O funded O by O “Fundamental O Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities” O XDJK2018C067 O and O a O Start-up B-ORG Fund I-ORG of I-ORG Southwest I-ORG University I-ORG Grant O SWU117036 O This O work O was O performed O in O part O at O the O Chapel O Hill O Analytical O and O Nanofabrication O Laboratory O CHANL O a O member O of O the O North O Carolina O Research O Triangle O Nanotechnology O Network O RTNN O which O is O supported O by O the O National B-ORG Science I-ORG Foundation O Grant O ECCS-1542015 B-AWARD as O part O of O the O National O Nanotechnology O Coordinated O Infrastructure O NNCI O The O research O was O supported O by O the O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG NIHR O Biomedical O Research O Centre O BRC O based O at O Guy’s O and O St O Thomas’ O NHS O Foundation O Trust O and O King’s O College O London O IS-BRC-1215-20006 O The O authors O acknowledge O support O by O the O Medical B-ORG Research I-ORG Council I-ORG MR/L023091/1 O Breast B-ORG Cancer I-ORG Now I-ORG 147 O working O in O partnership O with O Walk O the O Walk O Cancer B-ORG Research I-ORG UK I-ORG C30122/A11527 O C30122/A15774 B-AWARD Cancer O Research O UK O King’s O Health O Partners O Centre O at O King’s O College O London O The O Guy’s O and O St O Thomas’s O Foundation O Trust O Charity O Melanoma O Special O Fund O CRUK/NIHR O in O England/DoH O for O Scotland O Wales O and O Northern O Ireland O Experimental O Cancer O Medicine O Centre O C10355/A15587 O The O views O expressed O are O those O of O the O author(s O and O not O necessarily O those O of O the O NHS O the O NIHR O or O the O Department O of O Health O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO. O 61701241 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG NO. O BK20170935 B-AWARD and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG NO. O 17KJB510030 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31372080 O the O Committee B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Chongqing I-ORG China I-ORG cstc2017jcyjAX0455 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 106112013CDJZR290035 O This O work O was O supported O by O VEGA B-ORG grants O No. O 1/0202/16 B-AWARD and O No. O 1/0044/18 B-AWARD APVV B-ORG O 0235-12 B-AWARD “Biomedical O Center I-ORG Martin” O ITMS O Code O 26220220187 B-AWARD and O Center O of O Excellence O of O Perinatology O Research O CEPV O This O research O was O financially O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFD0501201 B-AWARD National B-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31472102 B-AWARD No.31772607 O and O Zhejiang B-ORG Provincial I-ORG Key I-ORG Science I-ORG Project I-ORG No. O 2015C03006 B-AWARD This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 31600617 B-AWARD 81802008 O the O Scientific B-ORG Research I-ORG Program I-ORG of I-ORG Hubei I-ORG Provincial I-ORG Education I-ORG Department I-ORG Q20181102 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG 2016CFB171 O and O the O Foundation O of O Wuhan O University O of O Science O and O Technology O 2016xz036 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31470088 O the O National B-ORG Key I-ORG Program I-ORG for I-ORG Research I-ORG and I-ORG Development I-ORG 2016YFD0100202 O and O the O Germplasm B-ORG Resources I-ORG Protection I-ORG Project I-ORG in I-ORG China I-ORG 2019NWB033 O The O funding O bodies O had O no O role O in O study O design O data O collection O and O analysis O interpretation O of O data O decision O to O publish O or O writing O the O manuscript O This O work O was O supported O by O funds O from O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2018YFD0200604 O Shandong B-ORG Modern I-ORG Agricultural I-ORG Technology I-ORG I-ORG Industry I-ORG System I-ORG SDAIT-02-10 O Shandong B-ORG ‘Double I-ORG Top’ I-ORG Program I-ORG SYL2017XTTD11 O and O ‘Taishan B-ORG Scholar’ I-ORG Construction I-ORG Project I-ORG TS201712023 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81402695 B-AWARD the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0904800 O 2019YFC0840607 B-AWARD and O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG China I-ORG 2017ZX09304010 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81900264 B-AWARD the O University B-ORG Stable I-ORG Support I-ORG Research I-ORG Funding I-ORG of I-ORG Shenzhen I-ORG 20200813153346001 O Start-up B-ORG Grant I-ORG from I-ORG Shenzhen I-ORG University I-ORG 2019136 O the O Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Commission I-ORG No. O JCYJ20210324130609027 B-AWARD JCYJ20190808141611189 B-AWARD JCYJ20190808163005631 B-AWARD the O Longgang B-ORG Medical I-ORG and I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG LGKCYLWS2020040 O LGKCYLWS2020045 B-AWARD Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG JSGG20201201100405014 O Basic B-ORG and I-ORG Applied I-ORG Research I-ORG Fund I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2020A1515011018 O This O study O has O received O funding O by O the O International B-ORG Collaboration I-ORG of I-ORG Technological I-ORG Research I-ORG Program I-ORG of I-ORG Chongqing I-ORG cstc2014gjhz110002 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O Grant O No. O 81571660 B-AWARD and O Clinical B-ORG Scientific I-ORG Foundation I-ORG of I-ORG Institute I-ORG of I-ORG Surgery I-ORG Research I-ORG Daping I-ORG Hospital I-ORG Third I-ORG Military I-ORG Medical I-ORG University I-ORG 2014YLC03 O This O study O was O supported O by O the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFA0501701 O the B-ORG National I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81773632 O 21575128 B-AWARD 81302679 B-AWARD and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2017QNA7032 O 2017QNA7033 B-AWARD 2017QNA7034 B-AWARD This O research O was O funded O by O National B-ORG Science I-ORG Foundation I-ORG CBET I-ORG Division I-ORG Grant O 1603450 B-AWARD to O H.Y O and O P.U.A O National B-ORG Science I-ORG Foundation I-ORG OIA/EPSCoR I-ORG Grant O 1632891 B-AWARD to O S.S O and O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O 2021M692505 B-AWARD to O H.Y O Open B-ORG fund I-ORG of I-ORG Guangxi I-ORG Colleges I-ORG and I-ORG Universities I-ORG Key I-ORG Laboratory I-ORG of I-ORG Biological I-ORG Molecular I-ORG Medicine I-ORG Research I-ORG GXBMR201601 O the O Youth B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangxi I-ORG Medical I-ORG University I-ORG GXMUYSF2014032 O and O Future B-ORG Academic I-ORG Star I-ORG of I-ORG Guangxi I-ORG Medical I-ORG University I-ORG WLXSZX17001 O funded O this O study O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31872352 O Research O Funds B-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2662018PY091 O and O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH O 1R01CA197976 O This O work O was O supported O by O grants O from O the O Tianjin B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 17JCQNJC15000),which O supported O the O data O analysis;the O Transformation B-ORG project I-ORG of I-ORG Tianjin I-ORG Agricultural I-ORG Achievements I-ORG 201604090 O which O supported O the O data O analysis O the O Special B-ORG funding I-ORG for I-ORG modern I-ORG agricultural I-ORG industrial I-ORG technology I-ORG system I-ORG CARS-47-Z01 O which O supported O the O whole O study O including O sample O collection O experiments O analysis O and O interpretation O of O data O the O Modern B-ORG industrial I-ORG technology I-ORG system I-ORG in I-ORG Tianjin I-ORG ITTFRS2017011 B-AWARD which O supported O the O experiments O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31872546 O 31472262 O and O the O China-ASEAN O Maritime O Cooperation O Fund O through O the O project O “China-ASEAN O Center O for O Joint O Research O and O Promotion O of O Marine O Aquaculture O Technology”,the O last O three O fundings O supported O the O writing O and O edition O of O the O manuscript O This O research O work O was O supported O by: O O the O Swedish O Research O Council O Vetenskapsrådet,www.vr.se O grant O no. O 2017-04655 B-AWARD received O by O MGG O O the O German O Research O Foundation O Deutsche O Forschungsgemeinschaft,www.dfg.de O grant O no. O 387071423 B-AWARD received O by O MN. O O the O European B-ORG Commission I-ORG https://ec.europa.eu/info/index_en O grant O no. O T1EDK-00120 B-AWARD received O by O LGA O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 33000-31611215 O Shenzhen B-ORG Dapeng I-ORG Peninsula I-ORG National I-ORG Geopark I-ORG Horizontal I-ORG Research I-ORG Grant I-ORG 33000-71021140 O as O well O as O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG 2018B O 030320001 O This O study O was O supported O by O grants O from O the O National B-ORG Research I-ORG Program I-ORG for I-ORG Genomic I-ORG Medicine I-ORG NSC O 100-3112-B-400-015 O National B-ORG Science I-ORG Council I-ORG NSC O 100-2314-B-400-002-MY3 O and O the O National B-ORG Health I-ORG Research I-ORG Institutes O Taiwan O NP-104-PP-04 O NP-105-PP-04 I-AWARD NP-104-SP-04 I-AWARD and I-AWARD NP-105-SP-04 O YLL O received O these O fundings O RAB O received O funding O from O the O California B-ORG Community I-ORG Foundation I-ORG under O Grant B-AWARD I-AWARD BA-17-136260 I-AWARD URL:https://www.calfund.org O the O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health I-ORG under O Grant B-AWARD I-AWARD R21MH107339 I-AWARD and I-AWARD T32MH109205 I-AWARD URL:https://www.nimh.nih.gov O and O the O UCLA B-ORG Center I-ORG for I-ORG HIV I-ORG Identification I-ORG Prevention I-ORG and I-ORG Treatment I-ORG CHIPTS O under O Grant B-AWARD I-AWARD P30MH058107 I-AWARD URL:http://chipts.ucla.edu O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41571203 O the O Basic O scientific O Research O Operating O Expenses O Project O of O the O Chinese B-ORG Academy I-ORG of I-ORG Geological I-ORG Sciences I-ORG YYWF201725 O China B-ORG Geological I-ORG Survey’s O Project O DD20190343 O and O the O China B-ORG Scholarship I-ORG Council I-ORG CSC O No.201908110325 O Dionysios O D. O Dionysiou O acknowledged O support O from O the O University O of O Cincinnati O through O a O UNESCO O co-Chair O Professor O position O on O “Water O Access O and O Sustainability” O and O the O Herman O Schneider O Professorship O in O the O College O of O Engineering O and O Applied O Sciences O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21808082 O 21878124 B-AWARD 21938004 B-AWARD the B-ORG 111 I-ORG Project I-ORG 111-2-06 O National B-ORG frst-class I-ORG discipline I-ORG program I-ORG of I-ORG Light I-ORG Industry I-ORG Technology I-ORG and I-ORG Engineering I-ORG LITE2018-24 O and O the O Opening B-ORG Project I-ORG of I-ORG Key I-ORG Laboratory I-ORG of I-ORG Carbohydrate I-ORG Chemistry I-ORG and I-ORG Biotechnology I-ORG Ministry I-ORG of I-ORG Education I-ORG KLCCB-KF201911 O This O research O was O funded O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Chongqing I-ORG China I-ORG grant O number O CSTB2022NSCQ-MSX0560 B-AWARD the O National B-ORG foreign I-ORG expert I-ORG project I-ORG grant O number O G2022165024L B-AWARD Graduate B-ORG Research I-ORG and I-ORG Innovation I-ORG Foundation I-ORG of I-ORG Chongqing I-ORG China I-ORG grant O number O CYS22108 B-AWARD Venture B-ORG I-ORG Innovation I-ORG Support I-ORG Program I-ORG for I-ORG Chongqing I-ORG Overseas I-ORG Returnees I-ORG and I-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG grant O number O 10611CDJXZ238826 B-AWARD This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81070597 O 81370853 I-AWARD and I-AWARD 81570613 O Science B-ORG and I-ORG Education I-ORG Development I-ORG Program I-ORG of I-ORG the I-ORG Jiangsu I-ORG Province I-ORG Health I-ORG Board I-ORG LJ201107 O Six B-ORG Talent I-ORG Peaks I-ORG of I-ORG the I-ORG Jiangsu I-ORG Province I-ORG Health I-ORG Bureau I-ORG 2011-WS-093 O to O RPJ O and O Research B-ORG and I-ORG Innovation I-ORG Program I-ORG for I-ORG Graduates I-ORG of I-ORG Jiangsu I-ORG Province I-ORG CXZZ13_0583 O to O YZG O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O financially O supported O by O the B-ORG Key I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Science I-ORG KFZD-SW-215 O ZDRW-ZS-2016-3 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31522002 O 31770105 B-AWARD and O Tianjin B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG 15PTCYSY00020 O We O thank O Dr. O Ping O Xu O from O Shanghai O Jiao O Tong O University O for O offering O B. O coagulans O XZL4 O and O Dr. O Oscar O P. O Kuipers O from O University O of O Groningen O for O offering O pMH77 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51561145015 O 31300487 B-AWARD the O Major B-ORG Program I-ORG of I-ORG the I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG of I-ORG China I-ORG 16KJA220004 O We O also O kindly O acknowledge O partial O support O from O the O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81302853 O Shanghai B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG 201540261 O Shanghai B-ORG Medical I-ORG and I-ORG Health I-ORG Development I-ORG Fund I-ORG 2015001 O and O Huashan B-ORG Hospital I-ORG North I-ORG 2015107 O 2015114 B-AWARD The O funder O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O funded O by O Fondazione B-ORG Italiana I-ORG Sclerosi I-ORG Multipla I-ORG FISM O aism.fism.it O grant O no. O 2020/R-Multi/024 B-AWARD to O A.S O and O partially O supported O by O the O Italian B-ORG Ministry I-ORG of I-ORG Health I-ORG RRC O R.L.S O is O funded O in O part O by O the O National B-ORG Institute I-ORG on I-ORG Aging I-ORG National I-ORG Institutes I-ORG of I-ORG Health I-ORG K24AG054415).The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O study O was O supported O by O the O Danish B-ORG Ministry I-ORG of I-ORG Foreign I-ORG Affairs O Grant O No. O 13-07KU B-AWARD Rufford B-ORG Small I-ORG Grant I-ORG RSG-19960-1 O and O USAID-funded B-ORG Hariyo I-ORG Ban I-ORG Program I-ORG of I-ORG WWF I-ORG Nepal I-ORG EN02 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Innovation B-ORG Fund I-ORG for I-ORG Technology I-ORG Based I-ORG Firms I-ORG 14C26213702067 O Independent B-ORG Innovation I-ORG and I-ORG Achievement I-ORG Transformation I-ORG Project I-ORG of I-ORG Shandong I-ORG Province I-ORG 2014CGZH0201 O the B-ORG Youth I-ORG Scientist I-ORG Foundation I-ORG of I-ORG the I-ORG Shandong I-ORG Province I-ORG ZR2014EMQ010 O and O Key B-ORG R I-ORG I-ORG D I-ORG Project I-ORG of I-ORG Shandong I-ORG Province I-ORG 2016GSF117008 O This O project O was O supported O by O Startup B-ORG Foundation I-ORG for I-ORG Introducing I-ORG Talent I-ORG of I-ORG Nanjing I-ORG University I-ORG of I-ORG Information I-ORG Science I-ORG and I-ORG Technology I-ORG 2014r020 O to O HF O The O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20170948 O to O HF O The O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG of I-ORG China I-ORG 17KJB610007 O to O HF O Top-notch B-ORG Academic I-ORG Programs I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PPZY2015C222 O to O HF) O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31572623 O to O YC O China O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 51973065 B-AWARD 61973127 O the O Science O and O Technology O Program O of O Guangzhou O No. O 201904010330 O 201707020011 O 2017B090901064 O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 2018ZD36 B-AWARD State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Pulp I-ORG and I-ORG Paper I-ORG Engineering I-ORG No. O 201827 B-AWARD and O Guangdong O Province O Science O Foundation O for O Cultivating O National O Engineering O Research O Center O for O Efficient O Utilization O of O Plant O Fibers O No. O 2017B090903003 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31730093 O 31670405 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0504804 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG lzujbky-2018-k01 O Funds O were O used O for O the O design O of O the O study O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O as O well O as O in O the O open O access O payment O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32272652 O to O J. O Lu O Shanghai B-ORG Municipal I-ORG Agriculture I-ORG and I-ORG Rural I-ORG Affairs I-ORG Commission I-ORG 2021-02-08-00-12-F00751 O Yunnan B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG 202005AF150023 O to O J. O Lu O This O work O was O supported O by O grants O from O GIZ B-ORG Contract O no. I-AWARD 81170269 O BMWi B-ORG KF2875802UL2 O and O DFG B-ORG HE O 6249/4-1 O to O RK. O No O role O in O study O design O in O the O collection O analysis O and O interpretation O of O data O in O the O writing O of O the O manuscript O and O in O the O decision O to O submit O the O manuscript O for O publication O was O played O by O the O funding O bodies O This O study O was O supported O in O part O by O Grants-in-Aid O for O Scientific O Research O A O JP16H02692 O B O JP17H04126 O JP18H02737 B-AWARD and O JP19H03863 B-AWARD C O JP18K07565 O JP18K09412 B-AWARD JP19K07890 B-AWARD JP20K10503 B-AWARD and O JP20K11020 B-AWARD Grants-in-Aid O for O Early-Career O Scientists O JP18K17925 O and O Grants-in-Aid O for O Research O Activity O Start-up O JP19K23971 O from O the O Ministry B-ORG of I-ORG Education I-ORG Culture I-ORG Sports I-ORG Science I-ORG and I-ORG Technology I-ORG of O Japan O by O Health O and O Labour O Sciences O Research O Grants O of O the O Ministry B-ORG of I-ORG Health I-ORG Labour I-ORG and I-ORG Welfare I-ORG of O Japan O 20FA1002 O and O by O the O Japan B-ORG Agency I-ORG for I-ORG Medical I-ORG Research I-ORG and I-ORG Development I-ORG JP20dk0207025 O JP20km0405202 B-AWARD and O JP20fk0108075 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81973233 O the B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Province I-ORG China I-ORG 2021C02062 O the B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Sci-Tech I-ORG University I-ORG 17042058-Y O and O the B-ORG Special I-ORG Program I-ORG for I-ORG Research I-ORG and I-ORG Development I-ORG of I-ORG Zhejiang I-ORG Sci-Tech I-ORG University I-ORG 2019Y009 O Supported O by O OTKA B-ORG K105247 B-AWARD to O B.V O and O by O the O Hungarian B-ORG Brain I-ORG Research I-ORG Program I-ORG KTIA_NAP_13-2 O 2015-0008 O to O B.V O This O research O was O also O supported O by O the O European O Union O and O the O State O of O Hungary O co-financed O by O the O European O Social O Fund O in O the O framework O of O TÁMOP B-AWARD 4.2.4.A/2–11/1-2012-0001 I-AWARD ‘National O Excellence I-ORG Program’ O to O B.V O This O study O was O funded O by O Shanghai B-ORG Shenkang I-ORG Hospital I-ORG Development I-ORG Center I-ORG Project I-ORG project O number O SHDC12012123 B-AWARD Shanghai B-ORG health I-ORG and I-ORG family I-ORG planning I-ORG commission I-ORG youth I-ORG Project I-ORG project O number O 20144Y0210 B-AWARD and O Novartis B-ORG Foundation I-ORG project O number O CRFB002ACN03T B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea O a O grant O funded O by O the O Ministry O of O Science O and O ICT O NRF-2020M3E4A1077861 O and O the O Ministry O of O Education O NRF-2018R1D1A1B07047512 O K.-W.P O acknowledges O support O from O Samsung B-ORG Science I-ORG and I-ORG Technology I-ORG Foundation I-ORG under O Project O No. O SSTF-BA1502-05 B-AWARD J.K O was O supported O in O part O by O KIAS B-ORG Advanced I-ORG Research I-ORG Program I-ORG CG014604 B-AWARD This O work O was O supported O by O the O Natural B-ORG Science I-ORG Basic I-ORG Research I-ORG Plan I-ORG in I-ORG Shaanxi I-ORG Province I-ORG of I-ORG China I-ORG 2018JM7056 O Undergraduates B-ORG Innovating I-ORG Experiment I-ORG Project I-ORG of I-ORG Nation I-ORG GJ201910698131 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81500928 O The O authors O gratefully O acknowledge O support O from O award O N00014-15-1-2502 B-AWARD from O the O Office B-ORG of I-ORG Naval I-ORG Research I-ORG of O the O USA O The O authors O also O gratefully O acknowledge O support O from O award O FA9550-13-1-0108 B-AWARD from O the O Air B-ORG Force I-ORG Office I-ORG of I-ORG Scientific I-ORG Research I-ORG of O the O USA O The O authors O additionally O acknowledge O support O from O award O 1607310 B-AWARD from O the O National B-ORG Science I-ORG Foundation’s O Graduate O Research O Fellowship O Program O to O K.C.H O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O PREDIMED-Plus O trial O was O supported O by O official O Spanish O institutions O for O funding O scientific O biomedical O research O CIBER O Fisiopatología O de O la O Obesidad O y O Nutrición O CIBERobn O and O Instituto O de O Salud O Carlos O III O ISCIII O through O the O Fondo B-ORG de I-ORG Investigación I-ORG para I-ORG la I-ORG Salud I-ORG FIS O which O is O co-funded O by O the O European B-ORG Regional I-ORG Development I-ORG Fund I-ORG four O coordinated O FIS O projects O led O by O J.S.-S O and O J.Vi O including O the O following O projects O PI13/00673 B-AWARD PI13/00492 I-AWARD PI13/00272 I-AWARD PI13/01123 I-AWARD PI13/00462 I-AWARD PI13/00233 I-AWARD PI13/02184 I-AWARD PI13/00728 I-AWARD PI13/01090 I-AWARD PI13/01056 I-AWARD PI14/01722 I-AWARD PI14/00636 I-AWARD PI14/00618 I-AWARD PI14/00696 I-AWARD PI14/01206 I-AWARD PI14/01919 I-AWARD PI14/00853 I-AWARD PI14/01374 I-AWARD PI14/00972 I-AWARD PI14/00728 I-AWARD PI14/01471 I-AWARD PI16/00473 O PI16/00662 O PI16/01873 O PI16/01094 O PI16/00501 O PI16/00533 O PI16/00381 O PI16/00366 O PI16/01522 O PI16/01120 O PI17/00764 O PI17/01183 O PI17/00855 O PI17/01347 O PI17/00525 O PI17/01827 O PI17/00532 O PI17/00215 O PI17/01441 O PI17/00508 O PI17/01732 O and O PI17/00926 O the O Special O Action O Project O entitled O Implementación O y O evaluación O de O una O intervención O intensiva O sobre O la O actividad O física O Cohorte O PREDIMED-Plus O grant O to O J.S.-S O the O Recercaixa O grant O to O J.S.-S O 2013ACUP00194 O a O grant O from O the O Fundació B-ORG la I-ORG Marató I-ORG de I-ORG TV3 I-ORG PI044003 O grants O from O the O Consejería O de O Salud O de O la O Junta O de O Andalucía O PI0458/2013 O PS0358/2016 O and O PI0137/2018),grants O from O the O Generalitat O Valenciana O PROMETEO/2017/017 O APOSTD/2019/136 O a O SEMERGEN O grant O a O CICYT O grant O provided O by O the O Ministerio O de O Ciencia O Innovación O y O Universidades O AGL2016-75329-R O and O funds O from O the O European O Regional O Development O Fund O CB06/03 O The O Spanish O Ministry O of O Science O Innovation O and O Universities O for O the O Formación O de O Profesorado O Universitario O FPU17/00785 O contract O Food O companies O Hojiblanca O Lucena O Spain O and O Patrimonio O Comunal O Olivarero O Madrid O Spain O donated O extra O virgin O olive O oil O and O the O Almond O Board O of O California O Modesto O CA O American O Pistachio O Growers O Fresno O CA O and O Paramount O Farms O Wonderful O Company O LLC O Los O Angeles O CA) O donated O nuts O This O call O is O co-financed O at O 50% O with O charge O to O the O Operational O Program O FSE O 2014-2020 O of O the O Balearic O Islands O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2019YFC0312601 B-AWARD Marine O S&T O Fund O of O Shandong O Province O for O Pilot O National O Laboratory O for O Marine O Science O and O Technology O Qingdao O No. O 2018SDKJ0402 O National O Science O and O Technology O Major O Project O for O Significant O New O Drugs O Development O No. O 2018ZX09735004 O the O grant O from O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 201762011 O and O 201941012 B-AWARD and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O No. O 81502977 B-AWARD This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2018YFC1200201 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O Nos O NSFC31372207 B-AWARD and I-AWARD 81570094 O and O a O start-up O grant O from O Nanjing B-ORG Agricultural I-ORG University I-ORG No. O 804090 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O American B-ORG Heart I-ORG Association I-ORG 16IRG26960017 O the O U.S O Army B-ORG Research I-ORG Office I-ORG W911NNF-14-D-0005 O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG K01HD091283 O and O Consejo O Nacional O de O Ciencia O y O Tecnología—CONACYT O scholarship O 625785/472472 O Foundation B-ORG Fighting I-ORG Blindness I-ORG BR-GE-0613-0618-BCM O and O National B-ORG Eye I-ORG Institute I-ORG R01EY022356 O R01EY020540 O to O R.C O 5T32EY007102-23 B-AWARD to O S.A O PI: O Dr O Graeme O Mardon O Baylor O College O of O Medicine O Ophthalmology O Core O 5P30EY002520-32 O for O TEM O imaging O Wellcome B-ORG Trust I-ORG 092621 O to O M.E.C O and O 093445 B-AWARD to O C.E.F O Fight O for O Sight O to O M.E.C O Funding O to O pay O the O Open O Access O publication O charges O for O this O article O was O provided O by O UCL O with O funds O from O the O Wellcome O Trust O This O research O was O supported O by O the O Projects O of O the O Scientific B-ORG Startup I-ORG Funds I-ORG for I-ORG Doctors I-ORG of I-ORG NWAFU(Z109021614 O which O was O awarded O to O Rui O Shi O And O by O the B-ORG Projects I-ORG of I-ORG the I-ORG Shaanxi I-ORG Province I-ORG Social I-ORG Science(2015N014 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 310850160666 O which O were O awarded O to O Shilei O Zhang O This O study O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 81372733/H1619 B-AWARD the B-ORG National I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 81302240 B-AWARD the B-ORG Fundamental I-ORG Scientific I-ORG Research I-ORG Fund I-ORG for I-ORG Colleges I-ORG and I-ORG Universities I-ORG Directly I-ORG Under I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG no. O lzujbky-2014-165 B-AWARD and O the O Twelfth B-ORG Five-Year I-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG projects I-ORG 2012BAI10B01 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O TP O is O supported O by O the O Schweizerischer B-ORG Nationalfonds I-ORG zur I-ORG Förderung I-ORG der I-ORG Wissenschaftlichen I-ORG Forschung I-ORG SNF O Grant O 105314_207580 B-AWARD NW O is O supported O by O Fonds B-ORG zur I-ORG Förderung I-ORG der I-ORG wissenschaftlichen I-ORG Forschung I-ORG FWF O P B-AWARD 31230-B27 O O Salzburger B-ORG Landesregierung I-ORG 20204-WISS/225/288/4-2021 O This O work O was O supported O by O the O following O grants O to O OJ: O the O James B-ORG S. I-ORG McDonnell I-ORG Foundation I-ORG Understanding I-ORG Human I-ORG Cognition I-ORG Collaborative I-ORG Award I-ORG grant O number O 220020448 B-AWARD Wellcome B-ORG Trust I-ORG Investigator I-ORG Award I-ORG in I-ORG Science I-ORG grant O number O 207550 B-AWARD as O well O as O the O Royal O Society O Wolfson O Research O Merit O Award O This O research O was O supported O by O the O DGIST B-ORG R&D I-ORG Program I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG ICT I-ORG and I-ORG Technology I-ORG of I-ORG KOREA I-ORG 20160165 O and I-AWARD 20160172 O Samsung B-ORG Advanced I-ORG Institute I-ORG of I-ORG Technology O and O the O Basic B-ORG Science I-ORG Research I-ORG Program I-ORG through I-ORG the I-ORG National I-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF I-ORG funded I-ORG by I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG ICT I-ORG and I-ORG Future I-ORG Planning I-ORG NRF-2015R1A2A2A03004088 O This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of O China O 2016YFD0100201-22 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31571694 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG KYZ201504 O the O MOE O 111 O Project O B08025 O the O MOE O Program O for O Changjiang O Scholars O and O Innovative O Research O Team O in O University O PCSIRT13073 O the O MOA O CARS-04 O program O the O Jiangsu O Higher O Education O PAPD O Program O and O the O Jiangsu O JCIC-MCP O program O The O research O was O partially O funded O by O SUTD B-ORG Start-up I-ORG Research I-ORG Grant I-ORG SRG-SMT-2020–156 O SUTD-ZJU B-ORG Grant I-ORG ZJUVP2000102 O and O SUTD B-ORG Kickstarter I-ORG Initiative I-ORG SKI_2021_02_05 O Research O was O funded O through O grants O from O CONICET B-ORG PIP O 6564 O FONCYT B-ORG PICT O 20805 I-AWARD 1471 I-AWARD and I-AWARD 2010-2779 O and O BBVA B-ORG Foundation O BIOCON03-162 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O research O funds O from O the O National B-ORG Cancer I-ORG Institute I-ORG of O NIH O United O States O 1R01CA195670-01,https://www.cancer.gov O to O DGH O the O Terry B-ORG Fox I-ORG Research I-ORG Institute I-ORG Initiative O New O Frontiers O Program O in O Cancer O TFF1021,https://www.tfri.ca O to O DGH O and O the O Carraresi B-ORG Foundation I-ORG and I-ORG the I-ORG Sumiko I-ORG Kobayashi I-ORG Marks I-ORG Memorial I-ORG OVCARE I-ORG Research I-ORG Grants I-ORG supported I-ORG by I-ORG the I-ORG VGH I-ORG I-ORG UBC I-ORG Hospital I-ORG Foundation I-ORG 2019 O competition,http://www.ovcare.ca O to O YW O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Work O in O the O author’s O laboratory O is O supported O by O the O Deutsche B-ORG Forschungsgemeinschaft I-ORG DFG O Collaborative O Research O Centre O 900 O projects O A2 O and O Z1, O grant O 158989968 B-AWARD Germany’s B-ORG Excellence I-ORG Strategy I-ORG – O EXC O 2155 O “RESIST” O – O project O ID O 39087428 B-AWARD and O the O Bundesministerium O für O Bildung O und O Forschung O BMBF O German O Center I-ORG for I-ORG Lung I-ORG Research I-ORG Disease I-ORG Area I-ORG Cystic I-ORG Fibrosis I-ORG at I-ORG BREATH O grant O 82DZL002A1 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 22106179 O the O Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Key I-ORG Project I-ORG ZR2020KB022 O and O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2021M693208 O This O work O was O supported O by O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81771393 O Beijing B-ORG Municipal I-ORG Science I-ORG I-ORG Technology I-ORG Commission I-ORG Z171100001017125 O and O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 7202210 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 51705101 B-AWARD Key O Laboratory O of O Micro-Systems O and O Micro-Structures O Manufacturing O Harbin O Institute O of O Technology O Ministry O of O Education O Grant O No. O 2019KM009 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2018T110293 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20192007 O and O Serra O Húnter O program O Generalitat O de O Catalunya O grant O number O UPC-LE-304 O year O 2018 O LI O thanks O the O Regional B-ORG Council I-ORG of I-ORG Franche-Comté I-ORG 2016YC-04540 O and I-AWARD 04560 O for O financial O support O JMC O and O MJOG O thank O Universidad O Camilo O José O Cela O UCJC O for O support O Grants O 2015–12 B-AWARD and I-AWARD 2015–21 O RA O and O KM O were O supported O by O ERDF/ESF B-ORG project I-ORG PharmaBrain I-ORG no. O CZ.02.1.01/0.0/0.0/16_025/0007444 B-AWARD and O University B-ORG of I-ORG Hradec I-ORG Kralove I-ORG no. O IRP1902/2018 B-AWARD VT2201/2018 B-AWARD This O work O was O supported O by O the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Guangzhou I-ORG Grant O No. I-AWARD 201707010299 O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG Grant O No. I-AWARD 2016B090918059 O and O Medical B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG Grant O No. I-AWARD B2019148 O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31871678 O 31571725 O the B-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG of I-ORG China I-ORG CAAS-ASTIP-IBFC O and O Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG 1610242019001 O 1610242019005 O The O funding O has O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG grant O number O 2020YFC2008302 B-AWARD the O 1.3.5 O Project B-ORG for I-ORG Disciplines I-ORG of I-ORG Excellence I-ORG West I-ORG China I-ORG Hospital I-ORG Sichuan I-ORG University I-ORG grant O number O ZYJC18028 B-AWARD Sichuan B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG grant O number O 2021YFG0136 B-AWARD and O the O Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG grant O number O 2023NSFSC1696 B-AWARD The O sponsor O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O Austrian B-ORG Science I-ORG Fund I-ORG FWF O project O I482-B09 B-AWARD Ecological O diversification O inPolynucleobacter O the O European B-ORG Science I-ORG Foundation I-ORG ESF O project O FREDI B-AWARD and O the O Austrian B-ORG Academy I-ORG of I-ORG Sciences I-ORG project O 23791 B-AWARD DOC O fellowship O This O work O was O supported O by O an O Open B-ORG Project I-ORG Application I-ORG by I-ORG the I-ORG Key I-ORG Laboratory I-ORG of I-ORG Parasite I-ORG and I-ORG Vector I-ORG Biology I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Health I-ORG People’s I-ORG Republic I-ORG of I-ORG China I-ORG WSBKFKT2019-05 O Hainan B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Special I-ORG Fund I-ORG ZDKJ2021035 O ZDYF2023SHFZ134 B-AWARD National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2021YFC23000800 O 20210021YFC2300804 B-AWARD This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81302531 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG of I-ORG China I-ORG BK20181492 O the O Talents B-ORG Planning I-ORG of I-ORG Six I-ORG Summit I-ORG Fields I-ORG of I-ORG Jiangsu I-ORG Province I-ORG 2013-WSN-037 O Postgraduate B-ORG Research I-ORG I-ORG Practice I-ORG Innovation I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG KYCX17_1287 O Postgraduate O Research O O Practice O Innovation O Program O of O Jiangsu O Province O SJCX18_0435 O the O National B-ORG Key I-ORG Clinical I-ORG Department I-ORG of I-ORG Laboratory I-ORG Medicine I-ORG of I-ORG China I-ORG in I-ORG Nanjing I-ORG Key I-ORG laboratory I-ORG for I-ORG Laboratory I-ORG Medicine I-ORG of I-ORG Jiangsu I-ORG Province I-ORG ZDXKB2016005 O and O by O the O Priority O Academic O Program O Development O of O Jiangsu O Higher O Education O Institutions O This O work O was O supported O by O grants O from O Young B-ORG Scientists I-ORG Fund I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31600067 O Key B-ORG Project I-ORG of I-ORG Intergovernmental I-ORG International I-ORG Cooperation I-ORG on I-ORG S&T I-ORG Innovation I-ORG of I-ORG the I-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG S2016G9072 O and O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2015M581074 O This B-ORG work I-ORG was I-ORG supported I-ORG by I-ORG the I-ORG Capital I-ORG Development I-ORG Scientific I-ORG Research I-ORG grant O number O 2011-5001-04 B-AWARD Chinese B-ORG National I-ORG Key I-ORG Technology I-ORG R&D I-ORG Program I-ORG grant O number O 2013BAI04B04 B-AWARD and O National B-ORG Scientific I-ORG Research I-ORG Fund I-ORG grant O number O 2011ZX09307-001-07 B-AWARD This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41706175 O and O 31702355 B-AWARD the O Open O Fund O of O Qingdao O National O Laboratory O for O Marine O Science O and O Technology O OF2018NO03 O and O 20173B03 O Open O Fund O of O CAS O Key O Laboratory O of O Marine O Ecology O and O Environmental O Sciences O Institute B-ORG of I-ORG Oceanology I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG KLMEES201804 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2017BD007 O and O First O Class O Fishery O Discipline O Programme O in O Shandong O Province O China O This O research O was O funded O by O the O National B-ORG Institutes I-ORG of I-ORG Health O 5U19AI062629 B-AWARD National O Institutes O of O Health O P20GM103648 B-AWARD U.S B-ORG Department I-ORG of I-ORG Veterans I-ORG Affairs O I01BX001937 B-AWARD Presbyterian B-ORG Health I-ORG Foundation O PHF B-AWARD Team I-AWARD Science I-AWARD Grant I-AWARD I-AWARD Year I-AWARD 1, O and O University O of O Oklahoma O College B-ORG of I-ORG Medicine I-ORG Alumni I-ORG Association O COMAA B-AWARD Research I-AWARD Grant I-AWARD This O study O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81501185 B-AWARD Shandong B-ORG Provincial I-ORG Key I-ORG Research I-ORG I-ORG Development I-ORG Project O grant O number O 2017GSF218043 B-AWARD and O the B-ORG open I-ORG projects I-ORG of I-ORG Jiangsu I-ORG Key I-ORG Laboratory I-ORG of I-ORG New I-ORG Drug I-ORG Research I-ORG and I-ORG Clinical I-ORG Pharmacy I-ORG grant O number O KF-XY201407 B-AWARD Research O funding O support O for O this O work O was O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81873768 I-AWARD and I-AWARD 81671213 I-AWARD to O Dr. O Zhen O Wang O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG No.2017GSF218091 O to O Dr. O Zhen O Wang O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG No. O ZR2016HM33 I-AWARD to O Dr. O Dexiang O Liu O Additional O funding O was O provided O by O the O national B-ORG key I-ORG project I-ORG of I-ORG chronic I-ORG non-communicable I-ORG disease I-ORG of I-ORG China I-ORG No.2016YFC1300403 O to O Dr. O Wenqiang O Chen O National O Natural O Science O Foundation O of O China O No.81770436 O to O Dr. O Wenqiang O Chen O This O research O was O funded O by O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq O from O Brazil O grant O number O 306798/2020-4 B-AWARD Additionally O this O study O received O financial O support O from O the O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG CAPES O from O Brazil O finance O code O 001 B-AWARD FAPESQ O funding O No. O 04/2022—Apoio B-AWARD ao I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG do I-ORG Estado I-ORG da I-ORG Paraíba—grant O number O 3783/2022-0 B-AWARD Paraíba B-ORG State I-ORG Research I-ORG Foundation I-ORG FAPESQ O This O study O was O supported O by O the O Chinese B-ORG academy I-ORG medical I-ORG sciences I-ORG CAMS I-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG 2017-I2M-3-022 O the O Yunnan B-ORG Applied I-ORG Basic I-ORG Research I-ORG Projects I-ORG 2017FB115 O 2017ZF007 B-AWARD and B-AWARD 2017FB040 O the O Fund B-ORG for I-ORG Reserve I-ORG Talents I-ORG of I-ORG Young I-ORG and I-ORG Middle-aged I-ORG Academic I-ORG and I-ORG Technical I-ORG Leaders I-ORG of I-ORG Yunnan I-ORG Province I-ORG 2019HB043 O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC1306300 O 2018YFC1312001 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61633018 O 81671761 B-AWARD 81871425 O Beijing B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG PXM2020_026283_000002 O Beijing B-ORG Nature I-ORG Science I-ORG Foundation I-ORG 7161009 O and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG University I-ORG 2017XTCX04 O This O research O was O supported O by O Ministero B-ORG della I-ORG Salute I-ORG CO-2016-02361470 O Ricerca B-ORG Corrente O 5 B-AWARD × I-AWARD 1000 I-AWARD funds I-AWARD 2018–2019 O 5 B-AWARD × I-AWARD 1000 I-AWARD funds I-AWARD 2020 O and O by O Compagnia B-ORG di I-ORG San I-ORG Paolo I-ORG 2017-0529 O This O research O was O supported O by O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2013CB966802 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31370762 O 31030026 I-AWARD 31071119 I-AWARD 81372218 O and O National B-ORG Key I-ORG Technology I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2012BAI01B07 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Youth I-ORG Science I-ORG Foundation I-ORG Project I-ORG of I-ORG China O grant O number O 61901007 B-AWARD the B-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Project I-ORG of I-ORG Education I-ORG Department I-ORG of I-ORG Jilin I-ORG Province I-ORG China I-ORG grant O number O JJKH20210036KJ B-AWARD and O JJKH20230062KJ B-AWARD the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jilin I-ORG Province I-ORG China I-ORG grant O number O YDZJ202101ZYTS172 B-AWARD and O YDZJ202201ZYTS601 B-AWARD Young B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Team I-ORG of I-ORG Beihua I-ORG University O grant O number O 202016003 B-AWARD This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O China O No. O 2018A030310195 B-AWARD and O Guangzhou O Municipal O Science O and O Technology O Bureau O China O No. O 201804010338 O to O Xiaoai O Zhang O Tianjin B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 19YFZCSY00500 O to O Shan O Gao O and O Science O Foundation O of O Hebei O Normal O University O L2020B17 O and O Hebei B-ORG Provincial I-ORG Higher I-ORG Education I-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Foundation I-ORG QN2020162 O to O Ze O Chen O The O funding O bodies O played O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O supported O by O Innovation B-ORG Team I-ORG and I-ORG Talents I-ORG Cultivation I-ORG Program I-ORG of I-ORG National I-ORG Administration I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG No: O ZYYCXTD-D-202205 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2022M723416 O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG of I-ORG MOF I-ORG and I-ORG MARA I-ORG CARS-21 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32272007 O This O study O was O supported O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81873835 O Suzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG SS201702 O Medical B-ORG Research I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Public I-ORG Health I-ORG Commission(H2017065 O and O Jiangsu B-ORG Key I-ORG Talents I-ORG for I-ORG Maternal I-ORG and I-ORG Child I-ORG Health I-ORG FRC201715 O This O work O was O financially O supported O by O grants O from O the O Macao B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Fund I-ORG Project O code O 102/2016/A3 B-AWARD the O Shenzhen B-ORG Municipal I-ORG Government I-ORG of I-ORG China I-ORG JSGG20160229172752028 O JCYJ20160229172757249 B-AWARD , O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81670606 B-AWARD This O work O is O supported O by O grant O no. O XMLX201610 B-AWARD Beijing B-ORG municipal I-ORG administration I-ORG of I-ORG hospitals I-ORG clinical I-ORG technology I-ORG innovation I-ORG program O grant O no. O DFL20150801 B-AWARD Beijing B-ORG municipal I-ORG administration I-ORG of I-ORG hospitals I-ORG climbing I-ORG talent I-ORG training I-ORG program O and O grant O no. O 2016000020124G108 B-AWARD from O the O Beijing B-ORG outstanding I-ORG talents I-ORG project O Beijing B-ORG healthcare I-ORG system I-ORG specialist I-ORG training I-ORG program I-ORG 2014-3-059 B-AWARD and O Beijing O Municipal O Administration O of O Hospitals O Incubating O Program O PX2018035 O This O work O was O supported O by O the O NWO B-ORG No. O 865.13.00 B-AWARD the O Special B-ORG Research I-ORG Fund I-ORG BOF I-ORG of I-ORG Ghent I-ORG University I-ORG the I-ORG Ubbo I-ORG Emmius I-ORG sandwich I-ORG programme I-ORG of I-ORG the I-ORG University I-ORG of I-ORG Groningen I-ORG the I-ORG FWO I-ORG network I-ORG EVENET I-ORG No. O W0.003.16N B-AWARD and O the O FWO O No. O G018017N B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O Non-profit B-ORG Central I-ORG Research I-ORG Institute I-ORG Fund I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG to O M.D O 2021-RC310-013 O the B-ORG CAMS I-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG to O M.D O 2021-I2M-1-067 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG to O M.D O 82272757 O and O Beijing B-ORG Hope I-ORG Run I-ORG Special I-ORG Fund I-ORG of I-ORG Cancer I-ORG Foundation I-ORG of I-ORG China I-ORG to O M.D O LC2021R02 O This O work O was O funded O by O the O China B-ORG Scholarship I-ORG Council I-ORG grants O 201506170036 B-AWARD to O X.Z O and O 201708110184 O to O M.W O the O CONACyT O scholarship O 552592 B-AWARD to O E.V.M O the O Graduate B-ORG School I-ORG of I-ORG Medical I-ORG Sciences I-ORG of I-ORG the I-ORG University I-ORG of I-ORG Groningen I-ORG to O X.Z O M.W O M.A.C O E.V.M O G.B O and O J.M.v.D O and O the O Deutsche B-ORG Forschungsgemeinschaft I-ORG Grant O GRK1870 B-AWARD to O S.M O and O D.B.);Consejo O Nacional I-ORG de I-ORG Ciencia I-ORG y I-ORG Tecnología I-ORG 552592];Deutsche O Forschungsgemeinschaft O GRK1870];Graduate O School O of O Medical O Sciences O of O the O University O of O Groningen O not O applicable O This O work O was O suported O by O the O Russian B-ORG Science I-ORG Foundation I-ORG grant O no O 14-14-01179 B-AWARD the O Spanish B-ORG Research I-ORG Project I-ORG MariSymBiomics I-ORG CTM2013-43287-P O and O the O Consolidated B-ORG Research I-ORG Group I-ORG of I-ORG Marine I-ORG Benthic I-ORG Ecology I-ORG of I-ORG the I-ORG Generalitat I-ORG de I-ORG Catalunya I-ORG 2014SGR120 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the O Provincial B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Anhui I-ORG and I-ORG Guangdong I-ORG No.1608085MD85 O 2016A030313103 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.31570456 O with O additional O support O from O the O Cornell B-ORG University I-ORG Agricultural I-ORG Experiment I-ORG Station I-ORG federal O formula O funds O Project O No O NYC B-AWARD 147453 I-AWARD received O from O the O National O Institute O of O Food O and O Agriculture O NIFA O United O States O Department O of O Agriculture O USDA O Any O opinions O findings O conclusions O or O recommendations O expressed O in O the O publication O are O those O of O the O author(s O and O do O not O necessarily O reflect O the O view O of O the O NIFA O or O USDA O This O work O was O supported O by O the O Iketani B-ORG Science I-ORG and I-ORG Technology I-ORG Foundation I-ORG 0281001-A O Japan B-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG JP14453489 O Japan O Science O and O Technology O Agency O JST O Precursory B-ORG Research I-ORG for I-ORG Embryonic I-ORG Science I-ORG and I-ORG Technology I-ORG PRESTO O JPMJPR17P2 O and O Sumitomo B-ORG Foundation I-ORG 160963 O This O work O was O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O 2017YFD0201301-06 B-AWARD to O L.Z O the O National O Key O Research O and O Development O Program O of O China O 2018YFA0901800 O to O Y.X O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31570093 O and O 31870076 B-AWARD to O Y. O X O and O 21807110 B-AWARD to O C. O W O and O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG CAAS-ASTIP O to O Y.X O and O Y2020XK20 B-AWARD to O L.Z O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31372479 B-AWARD Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province O China O No. O 2015B090901059 B-AWARD and O the O National B-ORG Key I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG grant O 2017YFD0501404 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Joint B-ORG Fund I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG and I-ORG the I-ORG Karst I-ORG Science I-ORG Research I-ORG Center I-ORG of I-ORG Guizhou I-ORG Province O grant O number O U1812401 B-AWARD the O National O Natural O Science O Foundation O of O China O grant O number O 32000354 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Sichuan I-ORG Province O grant O number O 2022NSFSC0123 B-AWARD 2022NSFSC0130 B-AWARD 2022NSFSC1726 B-AWARD This O work O was O supported O by O grants O from O National B-ORG Science I-ORG I-ORG Technology I-ORG Major I-ORG Project I-ORG “Key I-ORG New I-ORG Drug I-ORG Creation I-ORG and I-ORG Manufacturing I-ORG Program” O No. O 2018ZX09711002 O Natural B-ORG Scientific I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81673463 O No. B-AWARD 81402503 O Science B-ORG and I-ORG technology I-ORG program I-ORG of I-ORG Guangzhou O China O No. O 201802020002 O Science B-ORG and I-ORG Technology I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG No, O 2016A030312014 O The O study O was O funded O by O projects O of O the B-ORG Scientific I-ORG and I-ORG Technological I-ORG Basic I-ORG Work I-ORG Special-Survey I-ORG of I-ORG Toxic I-ORG and I-ORG Hazardous I-ORG Chemicals I-ORG and I-ORG Water I-ORG Environment I-ORG in I-ORG Typical I-ORG Lakes I-ORG of I-ORG China I-ORG no. O 2015FY11-0900 B-AWARD Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 8152028 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 412015097 B-AWARD This O work O was O supported O by O the O National B-ORG Major I-ORG Scientific I-ORG Instrument I-ORG and I-ORG Equipment I-ORG Development I-ORG Project I-ORG No. O 2013YQ19046706 B-AWARD 2012YQ0401400901 O the O Foundation B-ORG of I-ORG Advanced I-ORG Space I-ORG Medico-Engineering I-ORG Research I-ORG Project I-ORG of I-ORG China I-ORG No. O 2015SY54A0501 B-AWARD and O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Space I-ORG Medicine I-ORG Fundamentals I-ORG and I-ORG Application I-ORG in I-ORG China I-ORG No. O SMFA09A06 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O People’s B-ORG Government I-ORG of I-ORG Guangdong I-ORG Province O 2023A1515010193 B-AWARD People’s O Government O of O Guangdong O Province O 2020A1515010929 B-AWARD Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou O 202002020020 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O 51878292 B-AWARD National O Natural O Science O Foundation O of O China O 51678245 B-AWARD This O work O was O supported O by O grants O from O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG 2015A030313073 O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG China I-ORG No. O 201510010289/1563000183 O Sun B-ORG Yat-Sen I-ORG University I-ORG Clinical I-ORG Research I-ORG 5010 I-ORG Program I-ORG No.2007010 O This O work O was O supported O by O research O grants O from O MUR B-ORG PRIN2015 O Ministry B-ORG of I-ORG Education I-ORG Universities I-ORG and I-ORG Research O 2015HRE757 B-AWARD and O the O Cariplo B-ORG Foundation I-ORG biomedical O science O Prog O 2017–0620 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31171608 O the O Special B-ORG Innovative I-ORG Province I-ORG Construction I-ORG in I-ORG Anhui I-ORG Province I-ORG 15czs08032 O the O Special B-ORG Project I-ORG for I-ORG Central I-ORG Guiding I-ORG Science I-ORG and I-ORG Technology I-ORG Innovatio I-ORG of I-ORG Region I-ORG in I-ORG Anhui I-ORG Province I-ORG 2016080503B024 O and O the O Programme O for O Changjiang O Scholars O and O Innovative O Research O Team O in O University O IRT1101 O These O funding O bodies O did O not O play O any O roles O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O study O was O supported O through O Public O Health O Service O Grant O 5R01EY015534 B-AWARD from O the O National B-ORG Eye I-ORG Institute I-ORG HAP O and O the O Oklahoma B-ORG Center I-ORG for I-ORG the I-ORG Advancement I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG OCAST O HR12-068 B-AWARD HAP O Research O reported O in O this O publication O was O also O supported O by O the O National O Eye O Institute O under O award O number O R21EY026229 B-AWARD AKJ O and O by O an O Institutional O Development O Award O IDeA O from O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG under O grant O number O U54GM104938 B-AWARD HAP O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O One O cohort O study O was O supported O by O funding O from O British B-ORG Heart I-ORG Foundation I-ORG project O grant O grant O number O PG/13/17/30050 B-AWARD and O another O by O a O Scottish O Executive O Chief B-ORG Scientist I-ORG Office I-ORG project O grant O number O CZH/4/439 B-AWARD J.C O was O supported O by O a O fellowship O from O the O British O Society O of O Heart O Failure O Funding O to O H.M O and O E.N‐K O was O provided O by O the O European B-ORG Commission I-ORG via O the O HOMAGE O project O HEALTH‐FP7‐305507 O C.D O and O J.J.V.M O are O supported O by O a O British O Heart O Foundation O Centre O of O Research O Excellence O Award O reference O numbers O RE/13/5/30177 B-AWARD and O RE/18/6/34217 B-AWARD This O work O was O supported O by O the B-ORG project I-ORG of I-ORG orthognathic I-ORG and I-ORG orthodontic I-ORG combination I-ORG therapy I-ORG LCJZ[2013]171 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG No. O 2017G006010 B-AWARD and O Clinical B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Plan I-ORG of I-ORG Jinan I-ORG 201805052 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O W. O J. O is O sponsored O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 71602134 B-AWARD Website:http://www.nsfc.gov.cn O Youth B-ORG Foundation I-ORG for I-ORG Humanities I-ORG and I-ORG Social I-ORG Sciences I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG No. O 19YJC630063 B-AWARD Website:http://www.moe.gov.cn O and O Youth B-ORG project I-ORG of I-ORG Education I-ORG Department I-ORG of I-ORG Sichuan I-ORG Province I-ORG No. O 17ZB0335 B-AWARD Website:http://edu.sc.gov.cn O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O in O part O by O Public O Health O Service O grants O R01CA201340 O and O 1R01EY028450 O from O the O NIH/NCI B-ORG and O NIH/NEI B-ORG respectively O to O Y.J O and O AI071002 B-AWARD and O HD079327 B-AWARD from O the O NIH/NIAID B-ORG and O NIH/NICHD B-ORG respectively O to O R.K.P O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O Development B-ORG Program I-ORG of I-ORG China I-ORG 2021YFD1600300 O Project B-ORG of I-ORG Hubei I-ORG Province I-ORG 2022CFC055 O 2022BGD008 B-AWARD Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Hubei I-ORG Province I-ORG 2022BBA0066 O Project B-ORG of I-ORG Hubei I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Science I-ORG 2023NKYJJ09 O Major B-ORG Project I-ORG of I-ORG Hubei I-ORG Hongshan I-ORG Laboratory I-ORG 2022hszd009 O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-23-G28 O Wuhan B-ORG Major I-ORG Project I-ORG of I-ORG Key I-ORG Technologies I-ORG in I-ORG Biological I-ORG Breeding I-ORG and I-ORG New I-ORG Variety I-ORG Cultivation I-ORG 2022021302024852 O Knowledge O Innovation O Program O of O Wuhan O City O and O Project O of O Agriculture O Department O of O Hubei O Province O This O research O was O funded O by O the O Newton B-ORG Fund I-ORG delivered O by O the O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG and O the O Economic O O Social O Research O Council O the O Department O for O International O Development O and O the O Indian O Department O of O Biotechnology O under O the O Newton O Fund O Global O Research O Partnership O in O Aquaculture O programme O BB/N00504X/1 O Sequencing O was O carried O out O at O the O Exeter O Sequencing O Service O using O equipment O funded O by O the O Wellcome B-ORG Trust I-ORG Institutional O Strategic O Support O Fund O WT097835MF O Wellcome O Trust O Multi O User O Equipment O Award O WT101650MA O and O BBSRC O LOLA O award O BB/K003240/1 O Research O reported O in O this O publication O was O supported O by O the O National B-ORG Cancer I-ORG Institute I-ORG and O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG of O the O National O Institutes O of O Health O under O award O numbers O 1R01CA176579 B-AWARD and O 1P50GM098911 B-AWARD Tiffani O A. O Jones O PhD O was O supported O by O a O Postdoctoral O Fellowship O PF-14-200-01-MPC B-AWARD from O the O American B-ORG Cancer I-ORG Society I-ORG and O Friends O of O Rob O Kinas O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O a O grant O from O the O Basic B-ORG Science I-ORG Research I-ORG Program I-ORG through I-ORG the I-ORG National I-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O 2014R1A1A2057957 O and O by O a O grant O from O Korea B-ORG National I-ORG Institute I-ORG of I-ORG Health O Ministry O of O Food O and O Drug O Safety O 14172MFDS974 O and O Korea O Healthcare O Technology O R&D O project O Ministry O for O Health O Welfare O and O Family O Affairs O Republic O of O Korea O Food B-ORG and I-ORG Drug I-ORG Administration I-ORG HI16C2177 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O jointly O supported O by O the O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2014CB542101 O and I-AWARD 2013CB910500 O China B-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG for I-ORG Prevention I-ORG and I-ORG Treatment I-ORG of I-ORG Infectious I-ORG Diseases I-ORG 2017ZX10203207 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81672848 O 81672820 I-AWARD and I-AWARD 81802891 O Program B-ORG for I-ORG Changjiang I-ORG Scholars I-ORG and I-ORG Innovative I-ORG Research I-ORG Team I-ORG the O Ministry O of O Education O China O IRT1118 O and O Sailing B-ORG Program I-ORG of I-ORG Shanghai I-ORG Science I-ORG and I-ORG Technology I-ORG Committee I-ORG 19YF1405000 O This O study O partially O supported O by O National B-ORG basic I-ORG research I-ORG program I-ORG of I-ORG China I-ORG 2015CB554505 O Shanghai B-ORG Technology I-ORG and I-ORG Science I-ORG Commission I-ORG Fund I-ORG Project I-ORG 15401932600 O Shanghai B-ORG Key I-ORG Laboratory I-ORG of I-ORG acupuncture I-ORG mechanism I-ORG and I-ORG acupoint I-ORG function I-ORG 14DZ2260500 O the B-ORG Three-Year I-ORG development I-ORG plan I-ORG project I-ORG for I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Health I-ORG Commission I-ORG ZY O 2018-2020)-CCCX-2001-05 O characteristic B-ORG discipline I-ORG building I-ORG projects I-ORG of I-ORG clinical I-ORG TCM I-ORG acupuncture I-ORG and I-ORG moxibustion I-ORG in I-ORG Pudong I-ORG new I-ORG area I-ORG PDZY-2018-0610 O and O Xinglin O Young O Talent O Program O in O Shanghai O University O of O Traditional O Chinese O Medicine O The O work O reported O in O this O publication O was O primarily O funded O by O a O Biomedical B-ORG Advanced I-ORG Research I-ORG and I-ORG Development I-ORG Authority I-ORG BARDA O cooperative O agreement O IDSEP140022 O in O the O Office O of O the O Assistant O Secretary O for O Preparedness O and O Response O ASPR O United O States O Department O of O Health O and O Human O Services O HHS O with O additional O support O provided O by O the O National O Institute O of O Allergy O and O Infectious O Diseases O National B-ORG Institutes I-ORG of I-ORG Health O Department O of O Human O and O Health O Services O under O grant O R01AI135673 B-AWARD and O by O the O Bill B-ORG and I-ORG Melinda I-ORG Gates I-ORG Foundation I-ORG under O grant O 42387 B-AWARD The O findings O and O conclusions O in O this O report O are O solely O those O of O the O authors O and O do O not O represent O the O views O of O the O United O States O Department O of O Health O and O Human O Services O or O its O components O This O study O was O supported O by O grants O U01CA194730 B-AWARD from O the O National B-ORG Cancer I-ORG Institute/National I-ORG Institutes I-ORG of I-ORG Health I-ORG NCI/NIH O and O U54MD012392 B-AWARD R01MD012767 B-AWARD from O National B-ORG Institute I-ORG on I-ORG Minority I-ORG Health I-ORG and I-ORG Health I-ORG Disparities/National I-ORG Institutes I-ORG of I-ORG Health I-ORG NIMHD/NIH O to O D.K.;U54 O AA019765 I-AWARD and O R01 B-AWARD AA028806 I-AWARD from O National B-ORG Institute I-ORG on I-ORG Alcohol I-ORG Abuse I-ORG and I-ORG Alcoholism I-ORG NIAAA O to O M.A.G O and O R35GM141944 B-AWARD from O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG NIGMS/NIH O to O H.W.R O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O number O 81673690 B-AWARD 81872977 O the B-ORG major I-ORG project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Tibet I-ORG autonomous I-ORG region I-ORG China I-ORG No. O XZ201801-GH-13 O and O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of O China O 2018ZX09735003-002 O This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG LYY18H310008 O to O GQ O and O LGF18H150007 B-AWARD to O GZ O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81671956 O and O the O Zhejiang B-ORG Provincial I-ORG Program I-ORG for I-ORG the I-ORG Cultivation I-ORG of I-ORG High-level I-ORG Innovative I-ORG Health I-ORG Talents I-ORG 2016-6 O to O QS, O and O the O National O Natural O Science O Foundation O of O China O 81570071 O and O 81772122 B-AWARD to O JX. O The O work O was O supported O by O the O following O Ministry O of O Science O and O Technology O formerly O the O National B-ORG Science I-ORG Council I-ORG NSC O 102-2320-B-038-009-),https://www.most.gov.tw/en/public O National B-ORG Taipei I-ORG University I-ORG of I-ORG Technology-Taipei I-ORG Medical I-ORG University I-ORG Joint I-ORG Research I-ORG Program I-ORG NTUT-TMU-101-18 O NTUT-TMU-102-09),http://www-en.ntut.edu.tw/bin/home.php,http://www.tmu.edu.tw/english/main.php O and O Career O Development O Grant O National B-ORG Health I-ORG Research I-ORG Institutes O Taiwan O NHRI-EX103-10234SC),http://english.nhri.org.tw/NHRI_WEB/nhriw001Action.do O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFA0901600 O the B-ORG Tianjin I-ORG Science I-ORG Fund I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG 17JCJQJC45300 O Science B-ORG and I-ORG Technology I-ORG Service I-ORG Network I-ORG STS I-ORG Initiative I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG CAS O KFJ-STS-ZDTP-065 O This O work O was O supported O by O theEuropean O Research I-ORG Foundation[742288 O theWellcome O Trust[100293/Z/12/Z O theEuropean O Molecular I-ORG Biology I-ORG Organisation[ALTF O 295-2015 O and O theJapanese O Organisation I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science[H28-1002 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 82273978 B-AWARD O China O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shaanxi I-ORG Province I-ORG No. O 2023-YBSF-629 B-AWARD and O the O Air B-ORG Force I-ORG Medical I-ORG University I-ORG JSTS201805 B-AWARD This O research O received O funding O from O the O National B-ORG Fund I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Development I-ORG FONDECYT O No.3210237 O to O P.P.-M O No. O 3210629 B-AWARD to O B.M.-L O No. O 1210440 B-AWARD to O P.B O No. O 1221345 B-AWARD to O J.C.R O the O Advanced B-ORG Research I-ORG Grant I-ORG from I-ORG Research I-ORG Direction I-ORG from I-ORG Universidad I-ORG Autónoma I-ORG de I-ORG Chile I-ORG DIUAV O No. O 03-2022 B-AWARD to O I.R O and O B.M.-L O the O Research B-ORG Direction I-ORG from I-ORG Universidad I-ORG de I-ORG La I-ORG Frontera I-ORG DIUFRO O No. O DI20-0128 B-AWARD to O P.B O DI20-0160 B-AWARD to O C.I O FONDEF B-ORG Idea I-ORG No. O ID21I10027 B-AWARD to O P.B O the O Millennium B-ORG Institute I-ORG on I-ORG Immunology I-ORG and I-ORG Immunotherapy I-ORG IMII O No. O ICN2021_045 B-AWARD to O P.P.-M O J.C.R O and O P.B O the O European B-ORG Research I-ORG Council I-ORG ERC I-ORG under I-ORG the I-ORG European I-ORG Union’s I-ORG Horizon I-ORG 2020 I-ORG Research I-ORG and I-ORG Innovation I-ORG Programme I-ORG No. O 825510 B-AWARD to O J.C.R O ANID/FONDAP B-ORG No. O 152220002 B-AWARD to O J.C.R O This O work O was O supported O by O a O grant O from O the O Center B-ORG for I-ORG Infectious I-ORG Disease I-ORG and I-ORG Cancer I-ORG Research I-ORG Kaohsiung I-ORG Medical I-ORG University I-ORG KMUTP105-E01 O a O grant O from O Kaohsiung B-ORG Medical I-ORG University I-ORG Research I-ORG Foundation I-ORG 105KMUOR02 O and O a O grant O from O Taiwan B-ORG Centers I-ORG for I-ORG Disease I-ORG Control I-ORG MOHW O 106-CDC-C-114-000115 O The O content O of O this O publication O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O view O of O any O government O or O institution O mentioned O above O This O work O was O supported O by O a O NHS B-ORG Research I-ORG Scotland I-ORG Senior I-ORG Clinical I-ORG Fellowship I-ORG SCAF/15/02 O awarded O to O S.V.K O S.V.K O R.D O and O A.H.L O also O acknowledge O funding O from O the O Medical B-ORG Research I-ORG Council I-ORG MC_UU_12017/13 O O MC_UU_12017/15 B-AWARD and O Scottish B-ORG Government I-ORG Chief I-ORG Scientist I-ORG Office I-ORG SPHSU13 O O SPHSU15 B-AWARD C.L.N O was O supported O by O a O Medical B-ORG Research I-ORG Council I-ORG fellowship I-ORG MR/R024774/1 O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2017YFD0500902 O the O Key B-ORG R&D I-ORG Program I-ORG of I-ORG Gansu I-ORG Province I-ORG of I-ORG China I-ORG Grant O No. O 17YF1NA070 B-AWARD and O the O National B-ORG Pig I-ORG Industrial I-ORG System I-ORG of I-ORG China I-ORG CARS-36-06B O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O “The O 14th O Five-Year O Plan” O of O Chinese B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2021YFD1900602-06 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51879132 O Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG No.Y2021YJ07 O and O the O Basic B-ORG Research I-ORG Project I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG FIRI2022-18 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51579106 O the O China B-ORG Modern I-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG CARS-4617 O the O Special B-ORG Fund I-ORG for I-ORG Economic I-ORG Development I-ORG of I-ORG Guangdong I-ORG province I-ORG SDYY-2018-07 O and O the O Open B-ORG Research I-ORG Fund I-ORG Program I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Hydraulics I-ORG and I-ORG Mountain I-ORG River I-ORG Engineering I-ORG Sichuan I-ORG University I-ORG Skhl1815 O This O work O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O 61801429 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG under O Grant O LY20F010001 B-AWARD and O LQ20F050010 B-AWARD This O work O was O also O supported O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG of I-ORG Zhejiang I-ORG Sci-Tech I-ORG University I-ORG under O Grant O 2021Q030 B-AWARD This O study O was O supported O by O the B-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG leaders I-ORG in I-ORG Central I-ORG Plains I-ORG Grant O No. O 194200510017 B-AWARD the B-ORG Provincial I-ORG Ministry I-ORG Co-construction I-ORG Project I-ORG from I-ORG the I-ORG Medical I-ORG Scientific I-ORG and I-ORG Technological I-ORG Research I-ORG Program I-ORG of I-ORG Henan I-ORG Province I-ORG Grant O No. O SBGJ2018020 B-AWARD and O the B-ORG Science I-ORG and I-ORG Technology I-ORG people-benefit I-ORG project I-ORG of I-ORG Zhengzhou I-ORG 2019KJHM0001 O The O National O Council O of O Scientific O and O Technological O Development O CNPq O Brazil O Tocantins O State O Government/Tocantins O State O Foundation O for O Research O FAPT-TO)/Secretariat O of O Planning O and O Budget O SEPLAN-TO O Graduate O Program O for O Biotechnology O Graduate O Program O for O Biodiversity O and O Biotechnology O of O Legal O Amazon O of O the O Vice-Rectory O of O Research O from O the O Federal O University O of O Tocantins O and O Graduate O Program O for O Biotechnology O of O the O State O University O of O Montes O Claros O supported O this O research O ASRC B-ORG FAPT/PPSUS837598/2016/FAPT/DESER/2022 O CNPq B-AWARD 315095/2018-0/305589/2021-0 O CRFM B-ORG CNPq O 302917/2019-5 O SE O CNPq O 304033/2021-9 O EEO B-ORG CNPq O 308576/2018-7 I-AWARD and O 427304/2018-0 B-AWARD FAPEMIG B-AWARD APQ I-AWARD 03771-18 O This O work O was O supported O by O the O Spanish O grant O of O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III I-ORG PI19/01353 O and O FEDER O European O Union O Fondazione B-ORG AIRC O grant O number O IG B-AWARD 2014 I-AWARD id. I-AWARD 15428 I-AWARD M.V O Ministero B-ORG della I-ORG Salute O grant O RF-2018-12366714 B-AWARD M.V O The O funders O had O no O role O in O the O study O design O data O collection O or O analysis O the O decision O to O publish O or O the O preparation O of O the O manuscript O This O study O was O supported O by O the O Finnish O Cultural B-ORG Foundation I-ORG to O L.N O NFBC1966 B-AWARD received O financial O support O from O the O University B-ORG of I-ORG Oulu O grant O No. O 24301140 B-AWARD and O ERDF O European B-ORG Regional I-ORG Development I-ORG Fund O grant O No. O 539/2010 B-AWARD A31592 B-AWARD This O work O was O supported O by O the O Medical B-ORG Research I-ORG Council I-ORG grant O number O MC_UU_00002/3 B-AWARD to O MJG O and O APM O the O Medical B-ORG Research I-ORG Council I-ORG Network I-ORG of I-ORG Hubs I-ORG for I-ORG Trials I-ORG Methodology I-ORG Research I-ORG grant O number O MR/L004933/1-N97 B-AWARD and O the O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG grant O number O NIHR-SRF-2015–08-001 B-AWARD to O TFJ O This O work O was O funded O by O Zhejiang B-ORG province I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG “Lingyan” I-ORG NO.2022C02030 O Zhejiang B-ORG province I-ORG commonweal I-ORG projects I-ORG NOLGN20C150009 O and O Zhejiang B-ORG province I-ORG Major I-ORG science I-ORG and I-ORG technology I-ORG Program I-ORG NO.2021C02065-5-2 O This O work O was O funded O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG MOST-2016YFC1303200 O MOST-2016YFC1303202 O Clinical B-ORG Capability I-ORG Construction I-ORG Project I-ORG for I-ORG Liaoning I-ORG Provincial I-ORG Hospitals I-ORG LNCCC-A01-2014 O and O Key B-ORG Laboratory I-ORG Programme I-ORG of I-ORG Education I-ORG Department I-ORG of I-ORG Liaoning I-ORG Province I-ORG LZ2015076 O This O work O was O supported O by O FEDER O funds O through O the O POCI—COMPETE B-ORG 2020—Operational I-ORG Programme I-ORG Competitiveness I-ORG and I-ORG Internationalization I-ORG in I-ORG Axis I-ORG I—Strengthening I-ORG Research I-ORG Technological I-ORG Development I-ORG and I-ORG Innovation I-ORG Project O No. I-AWARD 007491 O and O National O Funds O by O the O FCT—Foundation B-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG Project O UID I-AWARD Multi/00709 O The O NMR O spectrometers O are O part O of O the O Portuguese B-ORG NMR I-ORG Network I-ORG PTNMR O and O are O partially O supported O by O Infrastructure B-AWARD Project I-AWARD No. I-AWARD 022161 I-AWARD co-financed O by O the O FEDER O through O COMPETE O 2020 O POCI O and O PORL O and O the O FCT O through O PIDDAC O V.B B-ORG also O acknowledges O the O grants O BID/ICI-FC/Santander B-AWARD Universidades-UBI/2016 I-AWARD and O SFRH/BD/131059 B-AWARD 2017 I-AWARD FCT O It O is O also O acknowledged O the O C4-Cloud B-ORG Computing I-ORG Competences I-ORG Center I-ORG project O CENTRO-01-0145-FEDER-000019 O This O research O was O supported O by O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDA13020103 O Youth B-ORG Talent I-ORG Program I-ORG Supported I-ORG by I-ORG Laboratory I-ORG for I-ORG Marine I-ORG Fisheries I-ORG Science I-ORG and I-ORG Food I-ORG Production I-ORG Processes I-ORG Pilot I-ORG National I-ORG Laboratory I-ORG for I-ORG Marine I-ORG Science I-ORG and I-ORG Technology O Qingdao)(2018-MFS-T04 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2017YFC0506302 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41576145 O The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O interpretation O of O data O or O writing O of O the O manuscript O This O work O was O jointly O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0113200 O Science B-ORG and I-ORG Technology I-ORG program I-ORG of I-ORG Guangdong I-ORG Province O China O 2015B020214002 O and O Science B-ORG and I-ORG Technology I-ORG program I-ORG of I-ORG Guangzhou O China O 201508020105 O This O work O was O supported O by O the O Science B-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG of I-ORG Sichuan O 2021YFQ0071 O and O 2019YFN0174 B-AWARD The O Open B-ORG Research I-ORG Subject I-ORG of I-ORG International I-ORG Science I-ORG and I-ORG Technology I-ORG Cooperation I-ORG Australia I-ORG and I-ORG New I-ORG Zealand I-ORG Institute I-ORG of I-ORG Sichuan I-ORG AXYJ2022-012 O and O AXYJ2022-013 B-AWARD Chengdu B-ORG Science I-ORG and I-ORG Technology I-ORG Project-key I-ORG research I-ORG and I-ORG development I-ORG program O 2018-YF05-00213-SN O the B-ORG College I-ORG Students I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Training I-ORG Program I-ORG of I-ORG Sichuan I-ORG Province I-ORG S202110650007 O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81770589 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG No. O 17ZR1421500 B-AWARD the O Scientific B-ORG Research I-ORG Fund I-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG for I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG No. O 2014JQ019A B-AWARD and O the O Medical B-ORG Education I-ORG Research I-ORG Project I-ORG of I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG School I-ORG of I-ORG Medicine I-ORG No. O YB150712 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 11762007 B-AWARD 52065029 B-AWARD and O 51741505 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Province I-ORG China I-ORG Grant O Nos O 20212ACB204013 B-AWARD and O 20202BABL204038 B-AWARD and O Foundation B-ORG of I-ORG Jiangxi I-ORG Educational I-ORG Committee I-ORG Grant O No. O GJJ211323 B-AWARD Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Jingdezhen I-ORG City I-ORG Grant O No. O 20212GYZD009-08 B-AWARD Singapore B-ORG National I-ORG Research I-ORG Foundation I-ORG Investigatorship O NRF-NRFI2017-09 O Nanyang O Technological O University O NTU O Singapore O to O A.T.P O The O Balasubramanian O laboratory O is O core-funded O by O Cancer B-ORG Research I-ORG UK I-ORG C14303/A17197 O Cancer O Research O UK O programme O C9681/A18618 O S.B O is O a O Welcome B-ORG Trust I-ORG Senior O Investigator O 099232/Z/12/Z O The O authors O acknowledge O the O use O of O NMR O facilities O at O the O NTU O Institute O of O Structural O Biology O Funding O for O open O access O charge O Singapore O National O Research O Foundation O This O work O was O supported O by O the O CAS B-ORG “Light I-ORG of I-ORG West I-ORG China” I-ORG Program I-ORG Y7XB061B01 O the O Southeast B-ORG Asia I-ORG Biodiversity I-ORG Research I-ORG Institute I-ORG CAS I-ORG Y4ZK111B01 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31600531 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O project O was O sponsored O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O number O 71603187 B-AWARD to O Chun O Chen O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O number O LQ16G030011 B-AWARD to O Chun O Chen O the B-ORG Key I-ORG Social I-ORG Science I-ORG Project I-ORG for I-ORG University I-ORG Teachers I-ORG of I-ORG Zhejiang I-ORG China I-ORG Grant O number O 2014QN005 B-AWARD to O Chun O Chen O and O 111 B-ORG Project I-ORG Grant O number O B16031 B-AWARD to O Qi O Zhang O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Support O was O provided O by O contract O grant O sponsor O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Contract O grant O number O MOST B-AWARD 104-2314-B-038-025 I-AWARD https://www.most.gov.tw O Received O author O Chwen-Ming O Shih O contract O grant O sponsor O Taipei B-ORG City I-ORG Government I-ORG Contract O grant O number O 104XDAA00078 B-AWARD http://english.gov.taipei O Received O author O Ann-Jeng O Liu O contract O grant O sponsor O NTUT-TMU B-ORG Joint I-ORG Research I-ORG Program I-ORG Contract O grant O number O NTUT-TMU-102-03 B-AWARD http://www.tmu.edu.tw O Received O author O Chwen-Ming O Shih O contract O grant O sponsor O Taipei B-ORG Medical I-ORG University I-ORG Aim I-ORG for I-ORG the I-ORG Top I-ORG University I-ORG Project–Cancer I-ORG Translational I-ORG Center O contract O grant O number O TMUTOP103002-3 B-AWARD http://www.tmu.edu.tw O Received O author O Chwen-Ming O Shih O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO.81771522 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG NO.2017CFB409 O and O the O Hubei B-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG NO.B2019111 O Some O of O the O research O presented O in O this O paper O was O funded O by O grants O awarded O to O the O author O from O the O Department B-ORG of I-ORG Health I-ORG England I-ORG Policy I-ORG Research I-ORG Programme I-ORG Policy I-ORG Research I-ORG Unit I-ORG in I-ORG Behaviour I-ORG and I-ORG Health I-ORG PR-UN-0409-10109 O National B-ORG Institute I-ORG of I-ORG Health I-ORG Research I-ORG Senior I-ORG Investigator I-ORG Award O NF-SI-0513-10101 O and O Wellcome B-ORG Trust I-ORG The O Centre O for O the O Study O of O Incentives O in O Health O Strategic O Award O in O Biomedical O Ethics O 086031/Z/08/Z B-AWARD The O respective O funders O had O no O role O in O the O writing O analysis O or O interpretation O of O this O paper O This O work O was O supported O by O the O Consejo B-ORG Nacional I-ORG de I-ORG Ciencia I-ORG y I-ORG Tecnología I-ORG CONACYT O No. O 98508 B-AWARD 22508 I-AWARD and I-AWARD 220259 O Fronteras O de I-ORG la I-ORG Ciencia I-ORG No. O 2016-01-1716 B-AWARD FOMIX O YUC-2014-C17-247355 B-AWARD Victor O Manuel O Carballo-Uicab O was O financially O supported O by O CONACYT B-ORG PhD I-ORG grant O No. O 265369 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 51971150 B-AWARD 51605304 I-AWARD 51871157 I-AWARD and I-AWARD 51675347 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG grant O number O 2016A030310036 B-AWARD and I-AWARD 2017A030313309 O the O Science B-ORG Technology I-ORG and I-ORG Innovation I-ORG Commission I-ORG of I-ORG Shenzhen I-ORG Municipality I-ORG grant O number O JCYJ20170817101008562 B-AWARD JSGG20170824111725200 I-AWARD and I-AWARD JSGG20190219152602381 O and O the O Natural O Science O Foundation O of O Shenzhen O University O grant O number O 2017034 O This O work O was O supported O by O Startup B-ORG Fund I-ORG for I-ORG scientific I-ORG research I-ORG Fujian I-ORG Medical I-ORG University I-ORG Grant O number O 2016QH032 B-AWARD Fujian B-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG Grant O number O 2017J01203 B-AWARD and O Joint B-ORG Funds I-ORG for I-ORG the I-ORG innovation I-ORG of I-ORG science I-ORG and I-ORG Technology I-ORG Fujian I-ORG province I-ORG Grant O number O 2017Y9023 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG Key I-ORG Program I-ORG grant O number O 81630071 B-AWARD CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG CIFMS O grant O number O 2016-I2M-3-008 B-AWARD Aiyou B-ORG Foundation I-ORG grant O number O KY201701 B-AWARD Ministry B-ORG of I-ORG Education I-ORG Innovation I-ORG Team I-ORG development I-ORG project I-ORG grant O number O IRT-17R10 B-AWARD CAMS B-ORG Key I-ORG lab I-ORG of I-ORG translational I-ORG research I-ORG on I-ORG lung I-ORG cancer I-ORG grant O number O 2018PT31035 B-AWARD China B-ORG National I-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG grant O number O 81871889 B-AWARD Beijing O Natural O Science O Foundation O grant O number O 7172045 O Beijing O Novel O Program O Grants O cross-cooperation O grant O number O Z181100006218130 O CAMS O Innovation O Fund O for O Medical O Sciences O CIFMS O grant O number O 2017-I2M-1-005 O and O the O Non-profit O Central O Research O Institute O Fund O of O Chinese O Academy O of O Medical O Sciences O grant O number O 2018RC320009 O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China O grant O number O 2019YFC1315700 B-AWARD This O research O was O supported O by O the O Science B-ORG and I-ORG technology I-ORG major I-ORG project I-ORG of I-ORG Hunan I-ORG province I-ORG 2017NK1014 O the O Key B-ORG Technology I-ORG R&D I-ORG Program I-ORG of I-ORG Hunan I-ORG Province I-ORG 2016TP2007 O 2016NK2148 O and O the O National B-ORG Key I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2014BAC09B03-02 O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31860249 O and O 32160219 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Province I-ORG 20192BAB204011 O and O the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG Founded I-ORG by I-ORG the I-ORG Education I-ORG Department I-ORG of I-ORG Jiangxi I-ORG Province I-ORG GJJ190202 O This O work O was O supported O by O the B-ORG National I-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2013AA102507-2 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31272363 O and O Chongqing B-ORG Graduate I-ORG Student I-ORG Research I-ORG Innovation I-ORG Project I-ORG CYB14041 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 21805084 B-AWARD and O 21706061 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG No. O B2018502046 B-AWARD and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Nos O 2019MS110 B-AWARD and O 2017MS137 B-AWARD This O work O was O supported O by O NIH O grant O 8G12MD007602 B-AWARD from O the O National B-ORG Institute I-ORG on I-ORG Minority I-ORG Health I-ORG and I-ORG Health I-ORG Disparities I-ORG NIMHD O 1SC1AII03041-01A1 B-AWARD from O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG NIGMS O to O Q.H O and O 1SC2HD086066-01A1 B-AWARD from O Eunice O Kennedy O Shriver O National B-ORG Institute I-ORG of I-ORG Child I-ORG Health I-ORG and I-ORG Human I-ORG Development I-ORG NICHD O to O Y.O O T.S O is O an O MSM O Research O Initiative O for O Scientific O Enhancement O RISE O Scholar O The O funding O agencies O did O not O have O a O role O in O the O design O of O the O study O and O in O the O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 52205411 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation O grant O number O EZ53020003 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Shannxi I-ORG province O grant O number O 2022JQ-366 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG Central I-ORG Universities I-ORG of I-ORG China O grant O number O 2018YJS135 B-AWARD This O research O was O funded O by O Youth B-ORG Innovation I-ORG Promotion I-ORG Association I-ORG of I-ORG CAS O grant O number O 2020444 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grants O grant O number O 22076191 B-AWARD Anhui B-ORG Provincial I-ORG Key I-ORG R&D I-ORG Programs O grant O number O 202004i07020015 B-AWARD Collaborative B-ORG Innovation I-ORG Program I-ORG of I-ORG Hefei I-ORG Science I-ORG Center O grant O number O 2021HSC-CIP003 B-AWARD and O Dean’s B-ORG Fund I-ORG of I-ORG Hefei I-ORG Institute I-ORG of I-ORG Physical I-ORG Science O grant O number O YZJJZX202014 B-AWARD This O work O was O supported O by O the O Major B-ORG State I-ORG Basic I-ORG Research I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFA0205201 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 81925019 O U1705281 B-AWARD U22A20333 B-AWARD and O 82272144 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 20720190088 O 20720200019 B-AWARD and O 2020Y4003 B-AWARD the O Program B-ORG for I-ORG New I-ORG Century I-ORG Excellent I-ORG Talents I-ORG in I-ORG University O China O NCET‐13‐0502 O and O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2021T140399 O Australian O Government O Research O Training O Program O Scholarship O to O C.H.M.R O Jack B-ORG Brockhoff I-ORG Foundation I-ORG JBF O 4186 O 2016 O to O D.B.A O Newton O Fund O RCUK-CONFAP O Grant O awarded O by O the O Medical O Research O Council O MRC O and O Fundação O de O Amparo O à O Pesquisa B-ORG do I-ORG Estado I-ORG de I-ORG Minas I-ORG Gerais I-ORG FAPEMIG O MR/M026302/1 O to O D.B.A O D.E.V.P O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG of O Australia O APP1072476 O to O D.B.A O Victorian O Life O Sciences O Computation O Initiative O VLSCI O an O initiative O of O the O Victorian O Government O Australia O on O its O Facility O hosted O at O the O University O of O Melbourne O UOM0017 O Instituto O René O Rachou O IRR/FIOCRUZ O Minas O Brazil O and O Conselho O Nacional O de O Desenvolvimento O Científico O e O Tecnológico O CNPq O to O D.E.V.P O Department O of O Biochemistry O and O Molecular O Biology O University O of O Melbourne O to O D.B.A O Funding O for O open O access O charge O MRC O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31770333 O 31370329 B-AWARD and O 11631012 B-AWARD Program B-ORG for I-ORG New I-ORG Century I-ORG Excellent I-ORG Talents I-ORG in I-ORG University I-ORG NCET-12-0896 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG GK201403004 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81471366 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Bureau I-ORG of I-ORG HangZhou I-ORG Grant O No. O 20150733Q33 B-AWARD the O Science O and O Technology O Bureau O of O HangZhou O Grant O No. O 20170533B51 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Bureau I-ORG of I-ORG WenZhou I-ORG 2015Y0410 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21505029 O the O Key B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Hainan I-ORG Province I-ORG ZDYF2018110 O and O grants O from O the O Hainan B-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG Hnky2018-13 O The O authors O also O express O their O sincere O gratitude O to O Kobayashi O International O Scholarship O Foundation O This O study O was O funded O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81871306 O 81871930 B-AWARD 81902402 B-AWARD 81902901 B-AWARD 81972219 B-AWARD 82003019 B-AWARD 82103313 B-AWARD 82203201 B-AWARD 82273192 O Shanghai B-ORG Rising-Star I-ORG Program I-ORG 22QA1401700 O and O Shanghai B-ORG Sailing I-ORG Program I-ORG 19YF1407500 O 21YF1407600 B-AWARD All O these O study O sponsors O have O no O roles O in O the O study O design O in O the O collection O analysis O and O interpretation O of O data O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31872031 O 31672030 O Chongqing B-ORG Research I-ORG Program I-ORG of I-ORG Basic I-ORG Research I-ORG and I-ORG Frontier I-ORG Technology I-ORG cstc2018jcyjAX0285 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG XDJK2019AC004 O of O China O and O the O earmarked O fund O for O the O Modern O Agroindustry O Citrus O Technology O Research O System O of O China O CARS-27 O This O work O was O supported O by O the O European B-ORG Research I-ORG Council I-ORG funding O under O the O European O Community's O Seventh O Framework O Program O FP7/2007–2013)/ERC O grant O agreement O FUNMANIA-306707 B-AWARD to O Y.H.;https://erc.europa.eu O Israel B-ORG Science I-ORG Foundation I-ORG grants O 549/12 O and O 41/15 B-AWARD German B-ORG Israeli I-ORG Foundation I-ORG grant O I-192-418.13-2014 O and O Joint B-ORG Italian-Israeli I-ORG Laboratory I-ORG on I-ORG Application I-ORG of I-ORG Neuroscience I-ORG grant O 590308 O A.B O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Seventh B-ORG Framework I-ORG Programme I-ORG 263307 O Ministerio B-ORG de I-ORG Economía I-ORG y I-ORG Competitividad I-ORG SAF2014-53413-R O and O Eusko B-ORG Jaurlaritza I-ORG PI_2015_1_53 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O in O part O by O the O Project B-ORG of I-ORG Guangdong I-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG under O Grant O Numbers O 2021A1515011563 B-AWARD and O 2022A1515140009 B-AWARD the O Project B-ORG of I-ORG Dongguan I-ORG Social I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG under O Grant O number O 2020507140141 B-AWARD and O the O Open B-ORG Project I-ORG of I-ORG Hunan I-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Artificial I-ORG Intelligence I-ORG for I-ORG Medical I-ORG Imaging I-ORG under O Grant O Number O YXZN2022005 B-AWARD This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0600101 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41871044 O 31561123001 I-AWARD 31500502 O and O the O National O Key O Project O for O Basic O Research O 2012CB114504 O and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2018CDDY-S02-SCU O SCU2019D013 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 30271082 B-AWARD 30571496 B-AWARD the O Distinguished B-ORG Talents I-ORG Foundation I-ORG of I-ORG Henan I-ORG Province I-ORG of I-ORG China I-ORG 174200510001 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Henan I-ORG Province I-ORG of I-ORG China I-ORG 162300410158 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Projects O of O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG No. O 17ZR1416800 O the O Projects O of O Shanghai B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG No.2017BR043 O the O Projects O of O Shanghai B-ORG Hospital I-ORG Development I-ORG Center I-ORG SHDC12016236 O the O Projects O of O United B-ORG Public I-ORG Relations I-ORG of I-ORG Pudong I-ORG New I-ORG District I-ORG PW2017D-1 O This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China O grant O number O 2018YFC1503702 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG China O grant O number O CUG2018JM15 B-AWARD and O the O State B-ORG Scholarship I-ORG Fund I-ORG of I-ORG China I-ORG Scholarship I-ORG Council O grant O number O 201806415018 B-AWARD National B-ORG Key I-ORG R I-ORG D I-ORG Program I-ORG of I-ORG China O 2022YFD1400600 B-AWARD SQ2022YFE012608 B-AWARD China B-ORG Agriculture I-ORG Research I-ORG System I-ORG of O MOF O and O MARA O CARS-22 B-AWARD National B-ORG Science I-ORG Foundation I-ORG of O China O 32172415 B-AWARD This O work O was O supported O by O grants O from O ZonMw B-ORG Project O 113302001 B-AWARD received O by O A. O Aartsma-Rus O NeurOmics B-ORG FP7 O Agreement I-AWARD 2012-305121 O received O by O Prof O dr. O A. O Aartsma-Rus O and O AFM B-ORG 20251 B-AWARD dr. O M. O van O Putten O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O GDAS’ B-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Grant O No. O 2017GDASCX-0836 B-AWARD Startup O Funding O of O Guangdong B-ORG Institute I-ORG of I-ORG Applied I-ORG Biological I-ORG Resources I-ORG Grant O No. O GIABR-gjrc201601 B-AWARD the O GDAS B-ORG Special I-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG 2018GDASCX-0107 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31702068 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O T.K O FDA B-ORG Broad I-ORG Agency I-ORG Announcement I-ORG BAA O contract O FDABAA-15-00121 O to O the O Health O and O Environmental O Sciences O Institute O HESI O and O partly O through O federal O funds O from O the O National B-ORG Center I-ORG Institute I-ORG number O HHSN261200800001E B-AWARD and O European O Union’s O Horizon B-ORG 2020 I-ORG number O 726513).https://www.fda.gov/https://hesiglobal.org/https://ec.europa.eu/programmes/horizon2020/enThe B-AWARD funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31470201 O 31741003 B-AWARD the O International B-ORG Great I-ORG Science I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG No. O 153D31KYSB20170121 B-AWARD and O Shanghai B-ORG Agriculture I-ORG Applied I-ORG Technology I-ORG Development I-ORG Program O China O No. O 2018-02-08-00-12-F01555 B-AWARD This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81901006 O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG 2020A1515110051 O Scientific B-ORG Research I-ORG Talent I-ORG Cultivation I-ORG Project I-ORG of I-ORG Stomatological I-ORG Hospital I-ORG Southern I-ORG Medical I-ORG University I-ORG RC202005 O and O Science B-ORG Research I-ORG Cultivation I-ORG Program I-ORG of I-ORG Stomatological I-ORG Hospital I-ORG Southern I-ORG Medical I-ORG University I-ORG PY2020002 O Clinical B-ORG Research I-ORG Startup I-ORG Program I-ORG of I-ORG Southern I-ORG Medical I-ORG University I-ORG by I-ORG High-level I-ORG University I-ORG Construction I-ORG Funding I-ORG of I-ORG Guangdong I-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG LC2017PY001 O This O work O was O supported O by O the B-ORG Key I-ORG Program I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41830321 O the B-ORG National I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31770432 O the B-ORG National I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 O Program O 2013CB429904 O the B-ORG Science I-ORG and I-ORG Technology I-ORG Partnership I-ORG Program I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG KY201501008 O the B-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG in I-ORG Gansu I-ORG 17ZD2WA017 O and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG lzujbky-2018-107 O All O these O grants O support O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O Interdisciplinary B-ORG Centre I-ORG for I-ORG Clinical I-ORG Research I-ORG Erlangen I-ORG IZKF O project O J42 B-AWARD to O FF O theDeutsche O Forschungsgemeinschaft(DFG O AB393/2-2 B-AWARD and O byErlanger O Leistungsbezogene I-ORG Anschubsfinanzierung I-ORG und I-ORG Nachwuchsförderung(ELAN O 13-05-10-1 B-AWARD Abou O Jamra O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0300502-2 O the O Innovation B-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG CAAS-XTCX2016008 O and O the O Young B-ORG Talent I-ORG Support I-ORG Project I-ORG of I-ORG Northeast I-ORG Agricultural I-ORG University I-ORG 16QC09 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 31671665 B-AWARD and O 31871600 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Provincial I-ORG of I-ORG China I-ORG 2014J01093 O Sci-Tech B-ORG Development I-ORG Founds I-ORG of I-ORG Fujian I-ORG Agriculture I-ORG and I-ORG Forestry I-ORG University I-ORG NO O KF2015081 B-AWARD and O KF2015082 B-AWARD and O the B-ORG International I-ORG Sci-Tech I-ORG Cooperation I-ORG and I-ORG Exchange I-ORG Program I-ORG of I-ORG Fujian I-ORG Agriculture I-ORG and I-ORG Forestry I-ORG University I-ORG Grant O number O KXGH17014 B-AWARD This O work O was O financially O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG grant O number O 2017YFC1310000 B-AWARD the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG grant O number O 2018KFYXMPT015 B-AWARD and O Hubei B-ORG Technological I-ORG Innovation I-ORG Special I-ORG Fund I-ORG CN) O grant O number O 2019ACA132 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O financial O support O for O this O work O was O provided O by O the O Ministry B-ORG of I-ORG National I-ORG Defense I-ORG ROC I-ORG MAB-106-034 O National B-ORG Defense I-ORG Medical I-ORG Center I-ORG Tri-Service I-ORG General I-ORG Hospital I-ORG ROC I-ORG TSGH-C106-112 O Zouying B-ORG Branch I-ORG of I-ORG Kaohsiung I-ORG Armed I-ORG Forces I-ORG General I-ORG Hospital I-ORG ROC I-ORG ZBH O 105-07 O Taoyuan B-ORG Armed I-ORG Forces I-ORG General I-ORG Hospital I-ORG ROC I-ORG AFTYGH-104-27 O AFTYGH-105-29 B-AWARD Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG ROC I-ORG MOST-102-2314-B-016-009 O MOST-103-2314-B-016-013 B-AWARD and O Ministry B-ORG of I-ORG Economic I-ORG Affairs I-ORG ROC I-ORG program O grant O number O 98-EC-17-A-19-S2-0090 B-AWARD Additional O financial O support O was O provided O by O Teh-Tzer O Study O Group O for O Human O Medical O Research O Foundation O ROC O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No: O 81772331 B-AWARD 81772332 B-AWARD 333 B-ORG High-level I-ORG Talents I-ORG Training I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No: O BRA2018194 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No: O 2016M590431 B-AWARD Jiangsu B-ORG Provincial I-ORG Medical I-ORG Youth I-ORG Talent I-ORG No: O QNRC2016344 B-AWARD and O QNRC2016343 B-AWARD the O Six B-ORG Talent I-ORG Peaks I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No: O 2015-WSN-108 B-AWARD and O 2015-WSN-110 B-AWARD Social B-ORG Development I-ORG Projects I-ORG of I-ORG Yangzhou I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG No: O YZ2017073 B-AWARD and O Jiangsu B-ORG Provincial I-ORG Medical I-ORG Innovation I-ORG Team I-ORG No: O CXTDB2017004 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 12004182 B-AWARD T2125004 B-AWARD and O 11774173 B-AWARD Jiangsu B-ORG Province I-ORG Science I-ORG Foundation I-ORG No. O BK20200481 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2021M691587 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Nos O 30920021152 B-AWARD and O 30920041115 B-AWARD and O Funding B-ORG of I-ORG NJUST I-ORG No. O TSXK2022D002 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31970717 O 82170429 B-AWARD the O Chinese B-ORG Universities I-ORG Scientific I-ORG Fund I-ORG 2020TC015 O and O the O Beijing B-ORG Municipal I-ORG Natural I-ORG Science I-ORG Foundation I-ORG 7222111 O This O study O was O supported O by O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Guizhou I-ORG Province I-ORG in I-ORG China I-ORG no.[2016]7141 O and I-AWARD 2017]1106 O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Talent I-ORG Team I-ORG Project I-ORG of I-ORG Guizhou I-ORG Province I-ORG no.[2015]4019 O and O high-level B-ORG innovative I-ORG talents I-ORG training I-ORG project I-ORG of I-ORG Guizhou I-ORG Province I-ORG no.GZSYQCC[2016]004 O Funding O was O provided O in O part O by O the O Bavarian O Research O Foundation O BFS-ISAR O Aktenzeichen I-ORG AZ: B-AWARD 504/02 I-AWARD and O BFS-DES B-ORG Aktenzeichen I-ORG AZ: B-AWARD 668/05 O and O by O the O European B-ORG Union I-ORG FP7 I-ORG PRESTIGE O 260309 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31670033 B-AWARD and O No. O 31270084 B-AWARD the O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG No. O 2012CB721005 B-AWARD and O the O National O High O Technology O Research B-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2012AA022107 B-AWARD This O work O was O supported O by O the O National B-ORG Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases I-ORG NIAID O the O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health I-ORG NIMH O and O the O National B-ORG Institute I-ORG on I-ORG Drug I-ORG Abuse I-ORG NIDA O of O the O National O Institutes O of O Health O NIH O and O award O numbers O UM1AI068619 B-AWARD HPTN O Leadership O and O Operations O Center O UM1AI068617 B-AWARD HPTN O Statistical O and O Data O Management O Center O UM1AI068613 B-AWARD HPTN O Laboratory O Center O and O the O University O of O North O Carolina O at O Chapel O Hill O Center O for O AIDS O Research O P30 O AI50410 O The O present O study O was O supported O by O Ministry B-ORG of I-ORG Education I-ORG Culture I-ORG Sports I-ORG Science I-ORG and I-ORG Technology I-ORG MEXT O KAKENHI O Grant O Number O JP21119001 B-AWARD Japan B-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG JSPS O KAKENHI O Grant O Numbers O JP26253042 B-AWARD and O JP17K09172 B-AWARD and O Ministry B-ORG of I-ORG Health I-ORG Labour I-ORG and I-ORG Welfare I-ORG Industrial O Disease O Clinical O Research O Grants O Grant O Numbers O 170401-02 O and O 180701-01 B-AWARD This O work O was O financially O supported O by O the O Beijing B-ORG Municipal I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O Number O 6182006 B-AWARD the O Beijing B-ORG Nova I-ORG Program I-ORG Grant O Number O XX2018086 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O Grant O Number O 31872099 B-AWARD This O research O was O funded O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 51532006 B-AWARD 51172052 B-AWARD 51621091 B-AWARD and O 91326102 B-AWARD Program B-ORG for I-ORG New I-ORG Century I-ORG Excellent I-ORG Talents I-ORG in I-ORG University I-ORG No. O NCET-13-0177 B-AWARD the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 13-0177 O the O Science O and O Technology O Development O Foundation O of O China O Academy O of O Engineering O Physics O No. O 2013A0301012 O and O Science O and O Technology O Innovation O Research O Foundation O of O Institute O of O Nuclear O Physics O and O Chemistry O This O work O was O supported O by O EMIDA-ERA B-ORG Net I-ORG EU O 7th I-AWARD Framework I-AWARD programme O German B-ORG Federal I-ORG Office I-ORG for I-ORG Agriculture I-ORG and I-ORG Food I-ORG 2811ERA174 O and O Dutch B-ORG Ministry I-ORG of I-ORG Economic I-ORG Affairs I-ORG CVI O project I-AWARD no. I-AWARD 1600074-01 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O National B-ORG Key I-ORG R I-ORG I-ORG D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0500403 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31802044 O 31872335 I-AWARD and I-AWARD 31772576 O the O Sichuan B-ORG Province I-ORG I-ORG Chinese I-ORG Academy I-ORG of I-ORG Science I-ORG of I-ORG Science I-ORG I-ORG Technology I-ORG Cooperation I-ORG Project I-ORG 2017JZ0025 O the O Science B-ORG I-ORG Technology I-ORG Support I-ORG Program I-ORG of I-ORG Sichuan I-ORG 2016NYZ0042 O and I-AWARD 2017NZDZX0002 O the O Earmarked O Fund O for O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-35-01A O and O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M643514 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Grants O from O the O following O funds O and O organizations O supported O this O work O Söderström B-ORG König I-ORG Foundation I-ORG SLS-559921 O SLS-655791 B-AWARD Åke B-ORG Wiberg’s I-ORG Foundation I-ORG M15-0239 O and O the O Swedish B-ORG Research I-ORG Council I-ORG for I-ORG Health I-ORG Working I-ORG Life I-ORG and I-ORG Welfare I-ORG FORTE O 2015-00897 O to O C.Å O and O the O Uppsala-Örebro B-ORG Regional I-ORG Research I-ORG Council I-ORG RFR O 151751 O Mälardalen B-ORG University I-ORG Social I-ORG Contract I-ORG Samhällskontraktet I-ORG and I-ORG Mälardalens I-ORG Kompetenscentrum I-ORG för O Hälsa O och O Välfärd O MKHV O 2016/2199 O The O study O sponsors O had O no O role O in O the O data O analysis O data O interpretation O or O writing O of O the O report O This O work O was O supported O by O the O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG BB/J008605/1 O the O Medical B-ORG Research I-ORG Council I-ORG MR/K501335/1 O and O the O Wellcome B-ORG Trust I-ORG ISSF O award O funding O to O AGW O PhD O studentship O funding O was O provided O by O Consejo O Nacional O de O Ciencia O y O Tecnologia O CONACyT O Mexico O to O SG-M O Albaha O University O scholarship O Kingdom O of O Saudi O Arabia O to O AAAS O University O of O Malaya O Kuala O Lumpur O Malaysia O and O The O Higher O Education O Ministry O Malaysia O to O GM O King O Abdullah O scholarship O program O Kingdom O of O Saudi O Arabia O to O OR O The O funding O bodies O had O no O roles O in O the O design O or O execution O of O the O study O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 21203164 B-AWARD the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shandong I-ORG Province O grant O number O 2019GGX102043 B-AWARD the O Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation O grant O number O ZR2017MB055 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 32100065 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG of I-ORG China I-ORG No. O ZR2018QC002 B-AWARD the O Doctoral B-ORG Research I-ORG Startup I-ORG Foundation I-ORG of I-ORG Liaocheng I-ORG University I-ORG No. O 318052041 B-AWARD This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31571608 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20151311 O Major B-ORG Basic I-ORG Research I-ORG Project I-ORG of I-ORG the I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG 15KJA210003 O the B-ORG Open I-ORG Funds I-ORG of I-ORG the I-ORG Key I-ORG Laboratory I-ORG of I-ORG Plant I-ORG Functional I-ORG Genomics I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG ML201903 O the O Natural O Science O Foundation O of O Yangzhou O YZ2017118 O and O the O Molecular O Breeding O Technology O Construction O of O Public O Service O Platform O of O Yangzhou O YZ2017170 O This O research O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31960116 O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2018YFD0201504 O the O Educational O Commission O of O Jiangxi O Province O of O China O GJJ180747 O and O Science B-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Jiangxi I-ORG Province I-ORG 20171BCB23074 O and O the O earmarked O fund O for O Jiangxi O Agriculture O Research O System O JXARS-07 O J.J O was O supported O by O Deutsche B-ORG Forschungsgemeinschaft I-ORG DFG O JA B-AWARD 2461/2-1 O DFG O JA B-AWARD 2461/5-1 O and O Deutsche B-ORG Krebshilfe I-ORG No. O 111647 B-AWARD BKT O was O supported O by O DFG/TH O 2012/1-1 O DJCLS B-ORG 18/R/2017 B-AWARD and O TRANSCAN O BMBF O NIRBTEST O S.L O Sonja O Ludwig O was O supported O by O DFG/LU O 2270/1-1 O and O Stiftung O Tumorforschung O Kopf-Hals O This O work O was O supported O by O Chinese B-ORG National I-ORG Key I-ORG Technology I-ORG R&D I-ORG Program I-ORG of I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2017YFC0907604 O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2019ZX09734001-002-004 O Medical O and O health O science O and O technology O innovation O project O of O Chinese B-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG 2019-I2M-2-008 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81601430 O 81471615 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O projects O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41976137 O and O U1706208 B-AWARD the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 202172002 O and O the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC0310701 O The O work O was O financed O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFC0500905 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31400284 B-AWARD Applied B-ORG Basic I-ORG Research I-ORG Project I-ORG of I-ORG Shanxi I-ORG Province I-ORG No. O 201601D021111 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Service I-ORG Network I-ORG Initiative I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG KFJ-EW-STS-061 O Financial O support O was O provided O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFE0103800 O and O 2018YFGH000187 B-AWARD the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG CHD I-ORG 300102299302 O International B-ORG Collaborative I-ORG Research I-ORG of I-ORG Disaster I-ORG Prevention I-ORG Research I-ORG Institute I-ORG of I-ORG Kyoto I-ORG University I-ORG 2019W-02 O One O Hundred O Talent O Plan O of O Shaanxi O Province O Excellent B-ORG projects I-ORG for I-ORG science I-ORG and I-ORG technology I-ORG activities I-ORG of I-ORG overseas I-ORG staff I-ORG in I-ORG Shaanxi I-ORG Province I-ORG 2018038 O and O Special B-ORG funds I-ORG of I-ORG education I-ORG and I-ORG teaching I-ORG reform I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG China I-ORG 310629172112 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O We O also O appreciate O the O reviewers O for O providing O valuable O comments O This O research O work O was O supported O by O funds O received O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 31621005 O 31530053 B-AWARD and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG 2016YFD0100203 B-AWARD Talents B-ORG cultivation I-ORG plan I-ORG of I-ORG Xinjiang I-ORG the I-ORG project I-ORG of I-ORG train I-ORG youth I-ORG excellent I-ORG S&T I-ORG talents I-ORG 2017Q050 B-AWARD The O funding O numbers O provided O the O financial O support O to O the O research O programs O but O didn’t O involve O in O work O design O data O collection O analysis O and O preparation O of O the O manuscript O This O study O was O supported O by O the O Key B-ORG Project I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81530036 O the B-ORG National I-ORG Key I-ORG Scientific I-ORG Instrument I-ORG and I-ORG Equipment I-ORG Development I-ORG Project I-ORG 31627803 O Mission B-ORG Program I-ORG of I-ORG Beijing I-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospitals I-ORG SML20150801 O Beijing B-ORG Scholars I-ORG Program I-ORG and I-ORG Beijing I-ORG Brain I-ORG Initiative I-ORG from I-ORG Beijing I-ORG Municipal I-ORG Science I-ORG I-ORG Technology I-ORG Commission I-ORG Z161100000216137 O CHINA-CANADA B-ORG Joint I-ORG Initiative I-ORG on I-ORG Alzheimer’s I-ORG Disease I-ORG and I-ORG Related I-ORG Disorders I-ORG 81261120571 O Beijing B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG PXM2017_026283_000002 O Guiyang B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG 2016003 O This O work O was O supported O by O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 O program O 2015CB554002 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81672886 O 81402277 B-AWARD 81172055 B-AWARD and O 81472710 B-AWARD Postdoctoral B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 2016M592511 O Guangdong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG S2012010009643 O 2014A030313283 B-AWARD 2016A030310395 B-AWARD 2016A030310392 B-AWARD the B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Higher I-ORG Education I-ORG CXZD1016 O Guangzhou B-ORG Science I-ORG I-ORG Technology I-ORG Plan I-ORG Project I-ORG 201300000056 O This O work O was O supported O by O the B-ORG Strategic I-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDA20050203 O the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0505200 O and O grants-in-aid O from O the B-ORG Major I-ORG Program I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31590823 O The O authors O were O supported O by O grants O from O the O National B-ORG Special I-ORG Foundation I-ORG for I-ORG Transgenic I-ORG Species I-ORG of I-ORG China I-ORG 2014ZX0800950B O and O 2014ZX08006-003 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31522055 O 31530073 B-AWARD 31401073 B-AWARD and O 31472081 B-AWARD the O Key B-ORG Project I-ORG of I-ORG Sichuan I-ORG Education I-ORG Department I-ORG 15ZA0008/15ZA0003 O and O the O Program B-ORG for I-ORG Innovative I-ORG Research I-ORG Team I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2015TD0012 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31502065 O 31572517 B-AWARD the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0500407 O 2017YFD0501800 B-AWARD the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2013PY051 O 2662016Q003 I-AWARD and I-AWARD 2662015PY083 O Microbiome O analysis O was O supported O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH O through O the O National B-ORG Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases I-ORG NIAID O grant O R21AI119463 B-AWARD BF O O AG O Data O collection O was O supported O by O U01AI088654 B-AWARD AG) O and O contract O number O HHSN272201400031C O AG O and O a O career O development O award O from O the O Fogarty B-ORG International I-ORG Center I-ORG K02TW009483 O AG O Additional O funding O came O from O the O Tinker O Foundation O University O of O Michigan O Center O for O Latin O America O and O Caribbean O Studies O University O of O Michigan O International O Institute O and O University O of O Michigan O Rackham O Graduate O School O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2019YFA0705000 O 2022YFA1404600 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 12274133 B-AWARD 12004116 B-AWARD 12104159 B-AWARD 12192251 B-AWARD 11933005 B-AWARD 12134001 B-AWARD 61991444 B-AWARD Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG NO. O 21DZ1101500 B-AWARD Shanghai B-ORG Sailing I-ORG Program I-ORG 21YF1410400 O Shanghai B-ORG Pujiang I-ORG Program I-ORG 21PJ1403300 O Innovation B-ORG Program I-ORG for I-ORG Quantum I-ORG Science I-ORG and I-ORG Technology I-ORG 2021ZD0301403 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31801898 O to O F.C O 81502437 B-AWARD to O L.Z O 31570666 B-AWARD to O Z.W O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG 2018J01603 O to O F.C O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Ecological I-ORG Pest I-ORG Control I-ORG for I-ORG Fujian I-ORG and I-ORG Taiwan I-ORG Crops I-ORG SKB2017004 O to O F.C O This O work O was O supported O by O National B-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC-31201702 O and O NSFC-31471964 B-AWARD National B-ORG Key I-ORG Programme I-ORG of I-ORG Research I-ORG and I-ORG Development I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2017YFC0505202 O the B-ORG Strategic I-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDA19050201 O and O XDPB0202 B-AWARD Important B-ORG Research I-ORG Project I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG KJZG-EW-L13 O and O 2017 B-ORG Western I-ORG Light I-ORG Talent I-ORG Culture I-ORG Project I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Y7C3041 O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0301102-5 O the O Philosophy B-ORG and I-ORG Social I-ORG Science I-ORG Planning I-ORG Project I-ORG of I-ORG Henan I-ORG Province I-ORG China I-ORG 2018BZH005 O the O Science B-ORG and I-ORG Technology I-ORG Research I-ORG Project I-ORG of I-ORG Henan I-ORG Province I-ORG 182102110029 O and O the O Doctoral B-ORG Research I-ORG Fund I-ORG of I-ORG North I-ORG China I-ORG University I-ORG of I-ORG Water I-ORG Resources I-ORG and I-ORG Electric I-ORG Power I-ORG China I-ORG 4001/40534 O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O is O supported O by O the O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Plan I-ORG of I-ORG Southwest I-ORG Hospital I-ORG SWH2016JCYB-04 O SWH2016YSCXZD-10 B-AWARD Third B-ORG Military I-ORG Medical I-ORG University I-ORG Foundation I-ORG 2016XPY12 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51703243 O 30700814 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41771058 O 41371260 B-AWARD the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2015CB150802 O and O the O National B-ORG Key I-ORG Research I-ORG I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0501200 O and O the O National B-ORG Key I-ORG Basic I-ORG Survey I-ORG of I-ORG Resources I-ORG 2015FY110500 O This O work O was O supported O by O those O Funds O Key B-ORG Medical I-ORG Specialty I-ORG Fund I-ORG Projects I-ORG of I-ORG Shanghai I-ORG ZK2015A07 O for O design O of O the O study O Projects B-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG 201540259 O for O cell O lines O experiment O Projects B-ORG of I-ORG Shanghai I-ORG Science I-ORG and I-ORG Technology I-ORG Committee I-ORG 15411964800 O for O data O collection O and O analysis O This O study O was O financially O supported O by O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences O Grant O No. O XDA19050201 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31900327 O 31700353 B-AWARD Construction B-ORG of I-ORG Basic I-ORG Conditions I-ORG Platform I-ORG of I-ORG Sichuan I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG 2019JDPT0020 O Important B-ORG Research I-ORG Project I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG KJZG-EW-L13 O Western B-ORG Light I-ORG Talent I-ORG Culture I-ORG Project I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG 2016XBZG_XBQNXZ_B_008 O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. I-AWARD 31601284 O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Rice I-ORG Biology I-ORG Research I-ORG Project I-ORG 2017ZZKT10103 O and O Projects B-ORG of I-ORG International I-ORG Cooperation I-ORG and I-ORG Exchanges I-ORG NSFC I-ORG 31861143006 O This O research O was O supported O by O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG 2014A020208079 O 2015A020209091 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangzhou I-ORG Guangdong I-ORG Province I-ORG China I-ORG 201610010002 O the O Guangdong B-ORG Aacademy I-ORG of I-ORG Sciences I-ORG Outstanding I-ORG Young I-ORG and I-ORG Scientific I-ORG Talent I-ORG Foundation I-ORG rcjj2015 O and O the O GDAS O Special O Project O of O Science B-ORG and I-ORG Technology I-ORG Development I-ORG 2017GDASCX-0107 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31200192 B-AWARD the B-ORG self-determined I-ORG research I-ORG funds I-ORG of I-ORG CCNU I-ORG from I-ORG the I-ORG colleges’ I-ORG basic I-ORG research I-ORG and I-ORG operation I-ORG of I-ORG MOE I-ORG No. O CCNU11A0122 B-AWARD and O the B-ORG project I-ORG of I-ORG Hubei I-ORG Key I-ORG Laboratory I-ORG of I-ORG Genetic I-ORG Regulation I-ORG and I-ORG Integrative I-ORG Biology I-ORG No. O GRIB201306 B-AWARD The O funding O bodies O did O not O play O a O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O but O just O provide O the O financial O support O This O study O was O supported O in O part O by O Japan B-ORG Agency I-ORG for I-ORG Medical I-ORG Research I-ORG and I-ORG Development I-ORG 17ck0106168h0003 O 19cm0106601h0003 O to O T.Ki O National O Cancer O Center O Research O and O Development O Fund O 23-B-1 O and O 23-A-38 B-AWARD to O T.Ki O Princess B-ORG Takamatsu I-ORG Cancer I-ORG Research I-ORG Fund I-ORG 10-24206 O to O T.Ki O Scientific B-ORG Research I-ORG from I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG Culture I-ORG Sports I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Japan I-ORG 16H04701 O to O T.Ki O Salary O for O F.I.G O was O supported O by O Japan O Agency O for O Medical O Research O and O Development O 16ae0101011h0003 O It O was O funded O by O the B-ORG Suzhou I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG Grant O No. O SS201426 B-AWARD the B-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Jilin I-ORG Province I-ORG Grant O No. O 20130206059SF B-AWARD Jiangsu B-ORG Distinguished I-ORG Medical I-ORG Experts I-ORG Program I-ORG No. O 2016 O and O Gusu B-ORG Health I-ORG Leading I-ORG Talent I-ORG Plan I-ORG Grant O No. B-AWARD 025 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Education B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG Gansu I-ORG Province I-ORG GSSYLXM-02 O Shuangbao O Gun O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31960646 O Shuangbao O Gun O and O the O Innovation B-ORG Fund I-ORG Project I-ORG of I-ORG higher I-ORG education I-ORG in I-ORG Gansu I-ORG Province I-ORG 2021B-123 O Qiaoli O Yang O This O work O was O supported O by O the O Spanish B-ORG MINECO I-ORG MI2-Fish O AGL2013-48560 O and O Plà B-ORG de I-ORG promoció I-ORG de I-ORG la I-ORG investigació I-ORG de I-ORG la I-ORG Universitat I-ORG Jaume I-ORG I I-ORG P1•1B2015-59 O and O the O Generalitat B-ORG Valenciana I-ORG as O research O group O of O excellence O PROMETEO O II/2014/023 O PROMETEO B-AWARD II/2014/085 O Collaborative O Research O on O Environment O and O Food-Safety O ISIC/2012/016 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Special B-ORG Fund I-ORG for I-ORG Agro-scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG 201503114 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31471748 O and O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-04-PS13 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2662018JC018 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31401507 O Hubei B-AWARD No. I-AWARD 31401507 O the O Province O Technical O Innovation O Special O Major O Project O 2018ABA072 O and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2017YFD0400701-2 B-AWARD The O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31270045 O the O Foundation B-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG Innovative I-ORG Talents I-ORG of I-ORG Harbin I-ORG 2016RAQXJ142 O the O Heilongjiang B-ORG Natural I-ORG Science I-ORG Fund I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG JC2017010 O and O the O Foundation B-ORG for I-ORG Basic I-ORG Scientific I-ORG Research I-ORG of I-ORG Central I-ORG Public I-ORG Research I-ORG Institutes I-ORG Y2017JC16 O The O funders O had O no O role O in O study O design O data O collection O and O interpretation O or O the O decision O to O submit O the O work O for O publication O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG no. O 2017YFC1308900 B-AWARD the O Beijing B-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospital I-ORG Clinical I-ORG Medicine I-ORG Development I-ORG of I-ORG Special I-ORG Funding I-ORG Support I-ORG ZYLX201701 O the O Beijing B-ORG Municipal I-ORG Senior I-ORG Technical I-ORG Training I-ORG Plan I-ORG in I-ORG Health I-ORG System I-ORG 2015-3-073 O and O the O Beijing B-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospitals’ I-ORG Youth I-ORG Program I-ORG code O QML20151002 B-AWARD This O work O was O supported O in O part O by O the O Fund O for O Development O Projects O of O Science O and O Technology O in O High O school O from O Tianjin B-ORG Municipal I-ORG Education I-ORG Commission I-ORG China I-ORG grant O number O 20120621 B-AWARD the O Veterinary B-ORG Biotechnology I-ORG Scientific I-ORG Research I-ORG Innovation I-ORG Team I-ORG of I-ORG Tianjin I-ORG China I-ORG grant O number O TD12-5019 B-AWARD and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31572492 O 31072109 B-AWARD There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Funding O was O provided O by O the O Government B-ORG of I-ORG Spain I-ORG Fondo O de O Investigación O en O Salud-FIS O PI16/01908 O to O GR/SC O the O Government B-ORG of I-ORG Navarre I-ORG 045-2015 O to O SC O and O the O Institute B-ORG for I-ORG Culture I-ORG and I-ORG Society I-ORG of I-ORG the I-ORG University I-ORG of I-ORG Navarra I-ORG EASH O to O JI O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG No. O 2020YFH0129 B-AWARD the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2019YFD1002100 B-AWARD and O the B-ORG Program I-ORG Sichuan I-ORG Veterinary I-ORG Medicine I-ORG and I-ORG Drug I-ORG Innovation I-ORG Group I-ORG of I-ORG China I-ORG Agricultural I-ORG Research I-ORG System I-ORG No. O SCCXTD-2020-18 B-AWARD This O study O was O partially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 71761167001 B-AWARD the O Major B-ORG Projects I-ORG of I-ORG National I-ORG Social I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 19ZDA358 O 18ZDA332 B-AWARD 17ZDA325 B-AWARD Key B-ORG Projects I-ORG of I-ORG National I-ORG Social I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 16AZD058 O and O Key B-ORG Project I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG KFJ-FP-201906 O and O MOE B-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG Youth I-ORG Foundation I-ORG Project I-ORG of I-ORG Humanities I-ORG and I-ORG Social I-ORG Sciences I-ORG 19YJC630194 O Supported O byBiotechnology O and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Councilgrant O BB/R018928/1 B-AWARD DT, O JTG),Engineering O and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Councilgrant O IAA620 B-AWARD JTG O andBritish O Heart I-ORG FoundationPG/19/43/34432 O JTG O DT O This O work O was O supported O by O the O KWF B-ORG Bas I-ORG Mulder I-ORG Award I-ORG UL I-ORG 2015-7664 O the O ZonMw B-ORG Veni I-ORG grant I-ORG 016.176.l44 O the O Fight B-ORG Colorectal I-ORG Cancer-Michael’s I-ORG Mission-AACR I-ORG Fellowship I-ORG in I-ORG Young I-ORG Onset I-ORG Late-Stage I-ORG Colorectal I-ORG Cancer I-ORG Research I-ORG 2015 I-ORG 15-40-1645-DEMI O J. O van O den O Bulk O was O supported O by O an O LUMC B-ORG PhD I-ORG fellowship I-ORG This O paper O was O supported O in O part O by O the O Jonas O Children’s O Vision O Care O and O Bernard O O Shirlee O Brown O Glaucoma O Laboratory O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG P30EY019007 O R01EY018213 B-AWARD R01EY024698 B-AWARD R01EY026682 B-AWARD R21AG050437 B-AWARD R24EY027285 B-AWARD the O National B-ORG Cancer I-ORG Institute I-ORG Core O 5P30CA013696 O the O Foundation B-ORG Fighting I-ORG Blindness I-ORG TA-NMT-0116-0692-COLU O the O Research B-ORG to I-ORG Prevent I-ORG Blindness I-ORG RPB O Physician-Scientist B-AWARD Award O and O unrestricted O funds O from O RPB O New O York O NY, O USA O S.H.T O is O a O member O of O the O RD-CURE O Consortium O and O is O supported O by O Kobi O and O Nancy O Karp O the O Crowley O Family O Fund O the O Rosenbaum O Family O Foundation O the O Tistou O and O Charlotte O Kerstan O Foundation O the O Schneeweiss O Stem O Cell O Fund O New B-ORG York I-ORG State I-ORG C029572 O and O the O Gebroe O Family O Foundation O This O work O was O partially O supported O by O National B-ORG Natural I-ORG Science I-ORG foundation I-ORG of I-ORG China I-ORG No: O 62003065 B-AWARD Chongqing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO: O CSTB2022NSCQ-MSX1417 B-AWARD and O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Chongqing I-ORG Education I-ORG Commission I-ORG NO: O KJZD-K202200513 B-AWARD The O authors O acknowledge O grants O from O The O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81870660 O Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Foundation I-ORG 18ZR1405900 O Shanghai B-ORG Hospital I-ORG Development I-ORG Center I-ORG SHDC12016116 O The O funding O bodies O had O no O role O in O the O design O of O the O study O in O collection O analysis O interpretation O of O data O or O in O writing O of O the O manuscript O This O work O was O supported O by O the O Auckland B-ORG Medical I-ORG Research I-ORG Foundation I-ORG grant O number O 1114010 B-AWARD the O Marsden B-ORG Fund I-ORG Council O Auckland O NZ O grant O number O UOA1402 B-AWARD and O the O Neurological B-ORG Foundation I-ORG of I-ORG New I-ORG Zealand I-ORG grant O number O 1422-MS B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Gribble’s O effort O was O supported O in O part O by O funding O from O the O National B-ORG Institute I-ORG of I-ORG Environmental I-ORG Health I-ORG Sciences I-ORG P30 O ES019776 O and O by O an O Institutional O Grant O NA10OAR4170084 O to O the O Georgia O Sea O Grant O College O Program O from O the O National O Sea O Grant O Office O National B-ORG Oceanic I-ORG and I-ORG Atmospheric I-ORG Administration O United O States O Department O of O Commerce O The O CARRS O Study O was O funded O by O the O National B-ORG Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute I-ORG at O the O National O Institutes O of O Health O HHSN2682009900026C O and O the O Oxford O Health O Alliance O Vision O 2020 O of O the O UnitedHealth O Group O Minneapolis O MN, O U.S O Additional O support O was O provided O by O the O Fogarty O International O Center O and O the O Eunice B-ORG Kennedy I-ORG Shriver I-ORG National I-ORG Institute I-ORG of I-ORG Child I-ORG Health I-ORG and I-ORG Human I-ORG Development I-ORG at O the O National O Institutes O of O Health O 1 O D43 I-AWARD HD065249 O and O the O Emory O Global O Health O Institute O None O of O the O aforementioned O funding O sources O had O a O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O the O HCT B-ORG SURF I-ORG research I-ORG grant I-ORG fund O No O 113469 B-AWARD UCSI-Industry B-ORG research I-ORG grant I-ORG grant O code O IND-FAS-2022/002 B-AWARD and O Research B-ORG Excellence I-ORG I-ORG Innovation I-ORG Grant I-ORG REIG O grant O code O REIG-FAS-2020/067 B-AWARD This O research O was O funded O by O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG MOST O 110-2321-B-001-015 I-AWARD and O MOST B-AWARD 109-2311-B-001-040 O Academia B-ORG Sinica I-ORG AS-KPQ-110-ITAR-09 O and O the O Council B-ORG of I-ORG Agriculture I-ORG 111AS-1.6.1-ST-aI O and O 112AS-1.6.1-ST-a5 B-AWARD Taiwan O This O work O was O supported O by O National B-ORG Institutes I-ORG of I-ORG Health I-ORG grant O R01 B-AWARD GM117590 I-AWARD and O National B-ORG Science I-ORG Foundation I-ORG grant O DBI-1458059 B-AWARD to O NAR O National O Science O Foundation O grants O DEB B-AWARD 1020271 I-AWARD and O DEB B-AWARD 1241217 I-AWARD to O AL, O and O a O Stanford B-ORG Center I-ORG for I-ORG Computational I-ORG Evolutionary I-ORG and I-ORG Human I-ORG Genomics I-ORG Postdoctoral B-AWARD Fellowship I-AWARD to O OKK O American B-ORG Cancer I-ORG Society I-ORG DMC-RG-15-224 O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH O GM129342A1 O to O J..S O NIH O AI102696 O to O M.A.C O Johns O Hopkins O School O of O Medicine O Synergy O Award O to O J.S O and O M.A.C O Funding O for O open O access O charge O NIH O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31300726 B-AWARD to O LS, O No. O 51407020 B-AWARD to O KL, O No. O 31571454 B-AWARD to O ZHL O the O Specialized B-ORG Research I-ORG Fund I-ORG for I-ORG the I-ORG Doctoral I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG No. O 20120191120043 B-AWARD to O LS O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 106112017CDJXY290002 B-AWARD to O LS, O No. O 106112017CDJQJ298833 B-AWARD to O ZHL O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31471639 B-AWARD the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2018YFD0400600 B-AWARD 2017YFD0400106 O The B-ORG Opening I-ORG Foundation I-ORG of I-ORG University-Enterprise I-ORG Alliance I-ORG of I-ORG Food I-ORG Industry I-ORG in I-ORG Liaoning I-ORG Province I-ORG 2018LNSPLM0104 O provide O financial O support O for O supplementing O related O experiments O during O revision O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31601946 O and O Longshan B-ORG Academic I-ORG Talent I-ORG Research I-ORG Supporting I-ORG Program I-ORG of I-ORG SWUST I-ORG 17LZX671 O and O 18lzx661 B-AWARD Partial O support O was O provided O by O Hatch O funds O under O project O ILLU-538-914 B-AWARD to O JJL O National B-ORG Institute I-ORG of I-ORG Food I-ORG and I-ORG Agriculture I-ORG Washington O DC O This O research O was O funded O by O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG Models I-ORG of I-ORG Infectious I-ORG Disease I-ORG Agent I-ORG Study I-ORG MIDAS O 5U54GM088491-09 B-AWARD the O NIH B-ORG Big I-ORG Data I-ORG to I-ORG Knowledge I-ORG BD2K O program O 5K01ES026836-03 O and O 3K01ES026836-02S1 B-AWARD and O the O Bill B-ORG and I-ORG Melinda I-ORG Gates I-ORG Foundation I-ORG 49276 O Deutsche B-ORG Forschungsgemeinschaft I-ORG DFG I-ORG EXPAND-PD I-ORG CA2816/1-1 B-AWARD Deutsche B-ORG Forschungsgemeinschaft I-ORG DFG I-ORG CRC-1365 I-ORG Number O 394046635 B-AWARD subproject O A03 O European B-ORG Commission I-ORG Horizon I-ORG 2020—PACE I-ORG Grant O Agreement O Number O 733006 B-AWARD European B-ORG Commission I-ORG Horizon I-ORG 2020—HIPGEN I-ORG Grant O Agreement O Number O 779293 B-AWARD This O study O was O funded O by O The B-ORG National I-ORG Key I-ORG Technology I-ORG R&D I-ORG Program I-ORG 2006BAI15B04 O Chengdu B-ORG Municipal I-ORG Bureau I-ORG of I-ORG Science I-ORG and I-ORG Technology(0040405301091 O and O Sichuan B-ORG University(2016SCU11007 O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51603090 O Provincial O Policy O Guidance O Program O International O Scientific O and O Technological O Cooperation O BZ2018032 O Basic B-ORG Research I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG JUSRP51907A O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG JUSRP52007A O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 51504175 B-AWARD the B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 2013M542076 B-AWARD the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG WUT O 2014-IV-069 I-AWARD and I-AWARD 2017-ZH-A1-10 O the B-ORG National I-ORG College I-ORG Students I-ORG Innovative I-ORG Training I-ORG Program I-ORG 20171049708013 O and O China B-ORG Scholarship I-ORG Council I-ORG 201706955031 O This O work O was O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG for I-ORG Young I-ORG Scientists I-ORG of I-ORG China I-ORG Grant O No. O 31601631 B-AWARD the O Special B-ORG Foundation I-ORG for I-ORG Key I-ORG Research I-ORG Program I-ORG of I-ORG Guangzhou I-ORG Grant O No. O 201804020062 B-AWARD and O the O project O of O National B-ORG Program I-ORG on I-ORG Key I-ORG Basic I-ORG Research I-ORG Project I-ORG 973 O Program O Grant O No. O 2013CB127602 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O The B-ORG First I-ORG Affiliated I-ORG Hospital I-ORG of I-ORG Chengdu I-ORG Medical I-ORG College I-ORG No. O CYFY-GQ24 I-AWARD CYZYB20-17 O Sichuan B-ORG Medical I-ORG Committee I-ORG No. O Q20075 O and O Chengdu B-ORG Medical I-ORG Scientific I-ORG Research I-ORG Project I-ORG No. O 2021410 O The O authors O acknowledge O financial O assistance O from O the O Spanish O Ministerio B-ORG de I-ORG Ciencia I-ORG y I-ORG Tecnología I-ORG grant O AGL2009-07853/AGR B-AWARD the O Spanish O Ministerio B-ORG de I-ORG Economía I-ORG y I-ORG Competitividad I-ORG grant O AGL2013-44714-R B-AWARD co-financed O with O FEDER O founds O and O the O Junta B-ORG de I-ORG Castilla I-ORG y I-ORG León I-ORG to O Research O Groups O GR113 O The O Ph. O D. O work O of O RRB O was O supported O by O a O personal O grant O from O the O Universidad O de O León O Spain O This O work O was O supported O by O the O National O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31771056 O and O 81200931 B-AWARD the O Tsinghua B-ORG University I-ORG Initiative I-ORG Scientific I-ORG Research I-ORG Program I-ORG 20161080091 O the O 111 O Project O B17026 O and O a O special B-ORG fund I-ORG from I-ORG Key I-ORG laboratory I-ORG of I-ORG Neurodegenerative I-ORG diseases I-ORG Ministry I-ORG of I-ORG Education I-ORG PXM2019_026283_000002 O This O work O was O supported O by O the O Transdisciplinary O Research O on O Energetics O and O Cancer O Center O at O Washington O University O in O St. O Louis O The O center O is O funded O by O the O National B-ORG Cancer I-ORG Institute I-ORG at O the O National O Institutes O of O Health O U54 O CA155496-01 O Washington O University O in O St. O Louis O and O the O Alvin O J. O Siteman O Cancer O Center O Additional O support O was O received O from O the O National B-ORG Institute I-ORG of I-ORG Diabetes I-ORG and I-ORG Digestive I-ORG and I-ORG Kidney I-ORG Diseases I-ORG NIDDK O Grant O Number O 1P30DK092950 B-AWARD and O Washington B-ORG University I-ORG Institute I-ORG of I-ORG Clinical I-ORG and I-ORG Translational I-ORG Sciences I-ORG grant O UL1 B-AWARD TR000448 I-AWARD and O KL2 B-AWARD TR000450 I-AWARD from O the B-ORG National I-ORG Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences O The O contents O of O this O publication O are O solely O the O responsibility O of O the O authors O and O do O not O necessarily O represent O the O official O view O of O the O National O Institutes O of O Health O The O funding O agencies O played O no O role O in O the O conduct O of O the O research O or O preparation O of O the O article O This O study O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 31172332 I-AWARD 31472205 I-AWARD and I-AWARD 31402150 O the B-ORG Shanghai I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG for I-ORG Agriculture I-ORG no. O 2012-2-6 O the B-ORG Innovation I-ORG Action I-ORG Plan I-ORG Key I-ORG Basic I-ORG Research I-ORG Project I-ORG of I-ORG Shanghai I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG no. O 12JC1410600 O the B-ORG Innovation I-ORG Action I-ORG Plan I-ORG Key I-ORG Scientific I-ORG and I-ORG Technological I-ORG Projects I-ORG in I-ORG the I-ORG Field I-ORG of I-ORG Modern I-ORG Agriculture I-ORG of I-ORG Shanghai I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG no. O 13391901601 O and O the B-ORG Special I-ORG Fund I-ORG for I-ORG Central I-ORG Nonprofit I-ORG Research I-ORG Institutes I-ORG Fundamental I-ORG Research I-ORG no. O 2011JB02 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the B-ORG program I-ORG of I-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0100300 O the O Modern B-ORG Agricultural I-ORG Industry I-ORG Technology I-ORG System I-ORG of I-ORG China I-ORG CARS-18-05 O and O the B-ORG basal I-ORG research I-ORG fund I-ORG of I-ORG central I-ORG public-interest I-ORG scientific I-ORG institution I-ORG 1610162019010104 O The O funding O bodies O were O not O involved O in O the O design O of O the O study O collection O analysis O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health I-ORG MH-58846 O to O JB O and O T32-HD071845 B-AWARD to O AW O the O National B-ORG Science I-ORG Foundation I-ORG NSF-GRFP O DGE-1444932 I-AWARD to O AW O and O the O National B-ORG Center I-ORG for I-ORG Research I-ORG Resources I-ORG P51RR165 B-AWARD currently O supported O by O the O Office O of O Research O Infrastructure O Programs/OD O P51OD11132 B-AWARD This O review O was O supported O by O research O grants O from O The B-ORG Training I-ORG and I-ORG Financial I-ORG Program I-ORG for I-ORG Young I-ORG Doctors I-ORG of I-ORG Shanghai I-ORG Funding O No. O 20141060 B-AWARD Shanghai B-ORG Sailing I-ORG Program I-ORG Funding O No. O 16YF1415800 B-AWARD and O The B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Ningbo I-ORG Funding O No. O 2015D10006 B-AWARD All O funding O were O used O for O the O design O collection O analysis O and O interpretation O of O data O and O in O writing O in O the O manuscript O This O work O was O financially O supported O by O the O Research B-ORG on I-ORG Key I-ORG Technology I-ORG of I-ORG Ecological I-ORG Disease I-ORG and I-ORG Pest I-ORG Control I-ORG for I-ORG Barley I-ORG ZX202001ZY0043N O the O Special B-ORG Fund I-ORG Project I-ORG of I-ORG the I-ORG Central I-ORG Government I-ORG for I-ORG Supporting I-ORG the I-ORG Development I-ORG of I-ORG Local I-ORG Colleges I-ORG and I-ORG Universities I-ORG KY2022ZY-02 O and O the O 2019 B-ORG Innovation I-ORG Plan I-ORG for I-ORG Postgraduates I-ORG of I-ORG Tibet I-ORG Agricultural I-ORG and I-ORG Animal I-ORG Husbandry I-ORG University I-ORG YJS2019-22 O This O work O was O supported O by O grants O from O the O NIH B-ORG R01 O DK108773 B-AWARD to I-AWARD D.Y.O O the O American B-ORG Heart I-ORG Association I-ORG 14SDG19880020 O to I-AWARD D.Y.O O and O the O American B-ORG Diabetes I-ORG Association I-ORG Minority I-ORG Postdoctoral I-ORG Fellowship I-ORG 1-18-PMF-030 O to I-AWARD V.A.P O This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2022YFA1302701 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32030056 O the O King B-ORG Abdullah I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG KAUST O Office O of O Sponsored O Research O OSR O under O Award O OSR-2020-CRG9-4352 O and O the O Tsinghua-Foshan B-ORG Innovation I-ORG Special I-ORG Fund O TFISF-2022THFS6122 O The O project O was O supported O by O grants O from O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2019kfyXJJS087 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG No. O 2018J01382 B-AWARD of O China O and O Xiamen B-ORG Municipal I-ORG Bureau I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG No. O 3502Z20174063 B-AWARD Fujian O China O Financial O support O came O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 51506059 B-AWARD the O Promotion B-ORG Program I-ORG for I-ORG Young I-ORG and I-ORG Middle-aged I-ORG Teacher I-ORG in I-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG of I-ORG Huaqiao I-ORG University I-ORG no. O ZQN-PY403 B-AWARD the O Fujian B-ORG SSP I-ORG Foundation I-ORG FJ2016C024 O and O the O Huaqiao B-ORG University I-ORG Scientific I-ORG Research I-ORG Foundation I-ORG nos O 16BS801 B-AWARD and O 14BS305 O S.I.K O was O funded O by O a O Canadian B-ORG Cancer I-ORG Society I-ORG Research I-ORG Institute I-ORG Capacity O Development O Award O 702855 O at O the O time O that O the O workshop O forming O the O basis O for O this O paper O was O planned O and O her O attendance O at O the O conference O was O supported O by O a O University O of O Waterloo O International O Research O Partnership O Grant O R.H.K O was O supported O by O a O Medical B-ORG Research I-ORG Council I-ORG Fellowship O MR/M014827/1 O M.L.N O holds O relevant O funding O from O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG R01 O CA119171 O Open O access O funding O provided O by O University O of O Szeged O This O work O was O supported O by O a O grant O from O the O Ministry O of O National O Resources O EFOP-3.6.1-16-2016-00008 O to O AL, O GINOP B-ORG 2.3.2-15-2016-00030 B-AWARD to O KG, O and O 2.3.2-15-2016-00034 B-AWARD to O GJ O and O KG) O through O the O European O Union O Cohesion O Fund O At O the O time O of O the O experiments O KD O was O a O PhD O student O partly O supported O by O the O Theoretical O Medicine O Doctoral O School O University O of O Szeged O The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Open O access O was O provided O by O the O University B-ORG of I-ORG Szeged I-ORG Open I-ORG Access I-ORG Fund I-ORG 4323 O This O study O was O funded O by O the O PUHSC B-ORG Clinical I-ORG Research I-ORG Project I-ORG PUCRP201302 O the O Interdisciplinary B-ORG Medicine I-ORG Seed I-ORG Fund I-ORG of I-ORG Peking I-ORG University I-ORG BMU2018MX026 O the O Interdisciplinary B-ORG Clinical I-ORG Research I-ORG Project I-ORG of I-ORG Peking I-ORG University I-ORG First I-ORG Hospital I-ORG 2019CR33 O and O Scientific B-ORG Research I-ORG Seed I-ORG Fund I-ORG of I-ORG Peking I-ORG University I-ORG First I-ORG Hospital I-ORG 2018SF066 O This O work O was O supported O by O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 I-ORG Program I-ORG 2014CB744600 O National B-ORG High-tech I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2013AA01A606 O Key B-ORG Research I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG KJZD-EWL04 O and O the O Scientific B-ORG Foundation I-ORG of I-ORG the I-ORG Institute I-ORG of I-ORG Psychology I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Y4CX143005 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2020YFE0100200 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG No. O 202201010344 B-AWARD 20202030148 B-AWARD 2019050001 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG under O Grant O No. O 2021A1515010653 B-AWARD 2021A1515011388 B-AWARD the O Innovation B-ORG Research I-ORG Project I-ORG of I-ORG Foshan I-ORG Education I-ORG Bureau I-ORG under O Grant O No. O 2021XCL06 B-AWARD Guangdong B-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Optical I-ORG Information I-ORG Materials I-ORG and I-ORG Technology I-ORG No. O 2017B030301007 B-AWARD MOE B-ORG International I-ORG Laboratory I-ORG for I-ORG Optical I-ORG Information I-ORG Technologies I-ORG and I-ORG the I-ORG 111 I-ORG Project I-ORG Yunnan I-ORG expert I-ORG workstation I-ORG No. O 202005AF150028 B-AWARD and O the O Graduate B-ORG Research I-ORG and I-ORG Innovation I-ORG Foundation I-ORG of I-ORG Yunnan I-ORG Normal I-ORG University I-ORG YJSJJ22-B80 O This O work O was O supported O by O the O National B-ORG Nonprofit I-ORG Institute I-ORG Research I-ORG Grant I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Forestry I-ORG No. O CAFYBB2016SY008 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31872168 B-AWARD the O Zhejiang B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Program I-ORG on I-ORG Agricultural I-ORG New I-ORG Variety I-ORG Breeding I-ORG No. O 2016C02056-1 B-AWARD and O the O Agricultural B-ORG Projects I-ORG of I-ORG Public I-ORG Scientific I-ORG and I-ORG Technology I-ORG Research I-ORG Zhejiang I-ORG Province I-ORG No. O 2016C32G3030016 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 62072212 B-AWARD the B-ORG Development I-ORG Project I-ORG of I-ORG Jilin I-ORG Province I-ORG of I-ORG China I-ORG No. O 20220508125RC B-AWARD National B-ORG Key I-ORG R&D I-ORG Program I-ORG No. O 2018YFC2001302 B-AWARD and O the B-ORG Jilin I-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Big I-ORG Data I-ORG Intelligent I-ORG Cognition I-ORG No. O 20210504003GH B-AWARD This O research O was O supported O by O the O Southern O Taiwan O Science O Park O Bureau O South O Taiwan O Smart O Manufacturing O Industrial O Clusters O Taiwan O under O contract O 106SMIC-MC06 B-AWARD This O study O is O partially O supported O by O Kaohsiung O Medical O University O Research O Center O Grant O KMU-TC108A02 O grants O from O Academia O Sinica O Taiwan O to O Yi-Chia O Wu O AS-TM-108-02-01 O This O study O was O partially O funded O by O grants O from O CGMH B-ORG at I-ORG Linko I-ORG of I-ORG Taiwan I-ORG to O John O Yu O OMRPG3C0041 O to I-AWARD OMRPG3C0044 O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Taiwan I-ORG to O Yi-Chia O Wu O MOST O 103-2628-B-037-002-MY3 O Yi-Chia O Wu O kmtth-105-011 O kmtth104-011 B-AWARD grants O from O Kaohsiung B-ORG Medical I-ORG University I-ORG Hospital I-ORG to O Yi-Chia O Wu O kmuh98-8G42 O and I-AWARD kmuh99-9M54 O This O study O was O supported O by O the O Hainan B-ORG Provincial I-ORG Basic I-ORG and I-ORG Applied-Basic I-ORG Research I-ORG Program I-ORG Natural I-ORG Science I-ORG for I-ORG High-Level I-ORG Talents I-ORG No. O 2019RC326 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31670633 B-AWARD and O the O Earmarked B-ORG Fund I-ORG for I-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS33-ZP1 O The O funding O sources O had O no O role O in O the O decision O to O publish O the O manuscript O This O work O was O supported O by O the O European B-ORG Commission I-ORG FP7-Health-2010 B-AWARD Grant I-AWARD MEDIA-261409 I-AWARD to O Dirk O J. O Duncker O and O Daphne O Merkus O by O the O Netherlands B-ORG CardioVascular I-ORG Research I-ORG Initiative I-ORG CVON-RECONNECT B-AWARD 2014-11 I-AWARD to O Dirk O J. O Duncker O and O Daphne O Merkus O and O the O Academy B-ORG of I-ORG Finland I-ORG 251272 B-AWARD to O Ilkka O Heinonen O This O work O was O supported O by O the O Major B-ORG priority I-ORG projects I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2008C12004-3 B-AWARD Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG LY12C14004 B-AWARD Wenzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG Projects I-ORG CN) I-ORG N20150010 B-AWARD and O Agricultural B-ORG science I-ORG and I-ORG Technology I-ORG Achievements I-ORG Transformation I-ORG Fund I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2010D70088 B-AWARD The O four O fundings O was O received O by O Chai O YQ. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81673848 I-AWARD and I-AWARD 81603520 O the B-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG province I-ORG No. O 2016A030310084 I-AWARD and I-AWARD 2017A030313658 O the B-ORG Administration I-ORG of I-ORG Traditional I-ORG Medicine I-ORG of I-ORG Guangdong I-ORG province I-ORG No. O 20161063 I-AWARD and I-AWARD No. I-AWARD 20181068 O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 21616315 O the B-ORG Medical I-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2016111221315850 O and O the B-ORG Science I-ORG I-ORG Technical I-ORG Plan I-ORG of I-ORG Guangzhou I-ORG Guangdong I-ORG China I-ORG No. O 201707010100 I-AWARD and I-AWARD NO.201804010213 O The O funding O bodies O play O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81473095 B-AWARD 81273440 B-AWARD and O 91213302 B-AWARD the O Key O National O S&T O Program O “Major O New O Drug O Development” O of O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG No. O 2012ZX09504-001-003 B-AWARD Specialized O Research O Fund O for O the O Doctoral B-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG No. O 20130211130005 B-AWARD Research O Funds O for O the O Central B-ORG Universities I-ORG lzujbky-2013-151 O lzujbky-2015-308 B-AWARD lzujbky-2016-144 B-AWARD and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Gansu I-ORG Province I-ORG 145RJZA075 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Author O 1 O is O supported O by O an O Alfred O Deakin O Postdoctoral O Fellowship O Author O 2 O is O supported O by O a O Principal O Research O Fellowship O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG 1026216 O Author O 3 O is O supported O by O an O Australian B-ORG Research I-ORG Council I-ORG Future O Fellowship O FT130100637 O O Honorary O National B-ORG Heart I-ORG Foundation I-ORG of I-ORG Australia I-ORG Future O Leader O Fellowship O 100370 O The O Melbourne O InFANT O Program O was O funded O by O grants O from O the O National O Health O and O Medical O Research O Council O 425801 O O 1008879 B-AWARD Dr. O Srinivasan O acknowledges O funding O support O fromThrasher O Research I-ORG FundEarly O Career O Award O Award O 13379 B-AWARD Dr. O Finkelstein O Dr. O Mehta O and O Dr. O Erickson O acknowledge O funding O from O theNational O Institutes I-ORG of I-ORG Health I-ORG NIH)(NIH O R03 I-AWARD EB I-AWARD 023190 O Dr. O Mehta O and O Dr. O Erickson O acknowledge O funding O from O theNational O Science I-ORG Foundation I-ORG NSF)(grant O 1343058 B-AWARD andNutrition O International I-ORG formerly I-ORG Micronutrient I-ORG Initiative(project O 10-8007-CORNE-01 B-AWARD This O work O was O supported O by O the O National B-ORG Major I-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG of I-ORG China I-ORG 2017ZX09201001-004-005 O to O YC O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jilin I-ORG Province I-ORG of O China O 20180101250JC O to O YH O and O “13th B-ORG Five-Year” I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Jilin I-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG JJKH20180178KJ O to O YH O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Jiangsu O ProteLight O Pharmaceutical O O Biotechnology O Co O Ltd O provided O support O in O the O form O of O a O salary O for O author O YC, O but O did O not O have O any O additional O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the O Foundation B-ORG of I-ORG National I-ORG Key I-ORG Program I-ORG of I-ORG Research I-ORG and I-ORG Development I-ORG of I-ORG China I-ORG Grant O NO: O 2016YFC0900803 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O NO: O U1404814 B-AWARD 81573243 I-AWARD 81602925 O Foundation B-ORG of I-ORG Key I-ORG Scientific I-ORG and I-ORG Technological I-ORG Project I-ORG of I-ORG Henan I-ORG Province I-ORG Grant O No.182102310562 O Science B-ORG and I-ORG Technology I-ORG Foundation I-ORG for I-ORG Innovation I-ORG Talent I-ORG of I-ORG Henan I-ORG Province I-ORG Grant O NO: O 164100510021 B-AWARD Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Talents I-ORG Support I-ORG Plan I-ORG of I-ORG Henan I-ORG Province I-ORG Colleges I-ORG and I-ORG Universities I-ORG Grant O NO: O 14HASTIT035 B-AWARD High-level B-ORG Personnel I-ORG Special I-ORG Support I-ORG Project I-ORG of I-ORG Zhengzhou I-ORG University I-ORG Grant O NO: O ZDGD13001 B-AWARD The O funders O did O not O influence O any O stage O of O this O study O This O research O was O funded O by O the O Key B-ORG Research I-ORG Program I-ORG of I-ORG Frontier I-ORG Sciences I-ORG CAS I-ORG ZDBS-LY-7001 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41971071 O 42211540718 B-AWARD CAS B-ORG “Light I-ORG of I-ORG West I-ORG China” I-ORG Program I-ORG and I-ORG Top-notch I-ORG Young I-ORG Talents I-ORG Project I-ORG of I-ORG Yunnan I-ORG Provincial I-ORG “Ten I-ORG Thousand I-ORG Talents I-ORG Program” I-ORG YNWR-QNBJ-2018-146 O This O work O was O supported O by O the O Project O of O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51105167 B-AWARD the O Key B-ORG Project I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51290290 B-AWARD O 51290292 B-AWARD the O Postdoctoral B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 2013M530985 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG of I-ORG China I-ORG No. O Z201105 B-AWARD and O the O Project B-ORG of I-ORG Department I-ORG of I-ORG Education I-ORG in I-ORG Henan I-ORG Province I-ORG No. O 15A416004 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O project O has O been O funded O by O the O Leverhulme B-ORG Trust I-ORG Research O Leadership O Award O F/00268/AP B-AWARD the O European B-ORG Research I-ORG Council I-ORG grant O number O FP7 B-AWARD PRILANG B-AWARD GA283871 O and O the O Swiss B-ORG National I-ORG Science I-ORG Foundation I-ORG 310030_185324 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC1404603 O and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 3132019189 O 3132016337 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51479020 O This O research O was O funded O by O grants O from O the O Haihe B-ORG Laboratory I-ORG of I-ORG Cell I-ORG Ecosystem I-ORG Innovation I-ORG HH22KYZX0002 O to O Y.G O and O HH22KYZX0040 B-AWARD to O Y.L O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 92068204 O to O Y.G O 81970105 B-AWARD to O Y.L O and O 82200126 B-AWARD to O W.Z O the O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Science I-ORG 2021-I2M-1-019 O to O Y.G O and O W.Z O and O SKLEH-Pilot O Research O This O work O was O supported O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2572019BE05 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31501867 O and O 30770309 B-AWARD and O the O Innovation B-ORG Training I-ORG Program I-ORG for I-ORG College I-ORG Students I-ORG of I-ORG Northeast I-ORG Forestry I-ORG University I-ORG 201910225247 O Shenzhen O Fundamental O Research O Funding O No. O JCYJ20170817160808432 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O China O 2018A030313748 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51427805 B-AWARD Youth B-ORG Funding I-ORG of I-ORG Shenzhen I-ORG Graduate I-ORG of I-ORG Tsinghua I-ORG University I-ORG No. O QN20180003 B-AWARD National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG No. O 2016YFF0100704 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 41806175 B-AWARD Marine B-ORG Biology I-ORG and I-ORG Biotechnology I-ORG Laboratory I-ORG Youth I-ORG Foundation I-ORG YQ2018NO06 O Shandong B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2018GHY115023 O and O Joint B-ORG Research I-ORG Project I-ORG between I-ORG China I-ORG and I-ORG Japan I-ORG No. O 2017YFE0130900 O These O funders O provided O financial O support O for O the O purchase O of O instruments O and O reagents O for O research O Each O of O the O funding O bodies O took O part O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O the O writing O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 61601140 B-AWARD and I-AWARD 51505106 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG Central I-ORG Universities O grant O number O HIT.NSRIF.2019005 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation O grant O number O 2017M610207 B-AWARD and O the O Heilongjiang B-ORG Provincial I-ORG Postdoctoral I-ORG Science I-ORG Foundation O grant O number O LBH-Z16074 B-AWARD This O research O was O supported O financially O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG 2018YFD0100600 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31270386 O partly O by O the O open B-ORG funds I-ORG of I-ORG the I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Crop I-ORG Genetics I-ORG and I-ORG Germplasm I-ORG Enhancement I-ORG ZW201802 O and O the O Cyrus O Tang O Seed O Innovation O Center O Nanjing O Agricultural O University O The O funders O provided O the O financial O support O to O the O research O but O had O no O role O in O the O design O of O the O study O analysis O interpretations O of O data O and O in O writing O the O manuscript O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG grant O numbers O 2017YFA0205200 B-AWARD 2017YFC1308700 B-AWARD 2017YFC1309100 B-AWARD 2016YFC0103803 B-AWARD 2017YFA0700401 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 81771924 B-AWARD 81501616 B-AWARD 81227901 B-AWARD 81671851 B-AWARD 81527805 B-AWARD 61671449 B-AWARD and O 61622117 B-AWARD Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG grant O numbers O L182061 B-AWARD Z180001 B-AWARD the O Beijing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG grant O numbers O Z171100000117023 B-AWARD and O Z161100002616022 B-AWARD the O Instrument B-ORG Developing I-ORG Project I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG grant O number O YZ201502 B-AWARD and O the O Youth B-ORG Innovation I-ORG Promotion I-ORG Association I-ORG CAS I-ORG grant O number O 2017175 B-AWARD Institutional O or O infrastructure O support O were O provided O by O the O Ministry B-ORG of I-ORG Education I-ORG Youth I-ORG and I-ORG Sports I-ORG of I-ORG the I-ORG Czech I-ORG Republic I-ORG NPU O I I-AWARD nr.LO1604 O Charles B-ORG University I-ORG UNCE O 204012 O the O European B-ORG Regional I-ORG Development I-ORG Fund I-ORG – I-ORG OP I-ORG Prague I-ORG CZ.2.16/3.1.00/24022 O and O the O National B-ORG Center I-ORG of I-ORG Medical I-ORG Genomics I-ORG CZ.02.1.01/0.0/0.0/16_013/0001634 O – O modernization O of O infrastructure O and O research O of O genetic O variation O in O the O population O OP O RDE O This O work O was O supported O by O the O Ministry B-ORG of I-ORG Health I-ORG Czech I-ORG Republic I-ORG – I-ORG conceptual I-ORG development I-ORG of I-ORG research I-ORG organization I-ORG Motol I-ORG University I-ORG Hospital I-ORG Prague I-ORG Czech I-ORG Republic I-ORG 00064203 B-AWARD This O work O was O funded O by O the O National B-ORG Research I-ORG Development I-ORG and I-ORG Innovation I-ORG Office I-ORG NKFIH-K138090 O to O C.D O J.M O N.S O and O P.P.N O NKFIH-K142764 B-AWARD to O J.O O Z.M.K O C.D O J.M O T.B O and O N.S O NKFIH-FK128116 B-AWARD to O T.B O N.S O J.M O C.D O and O B.H O and O NKFIH-K132906 B-AWARD to O Z.V O Support O was O also O obtained O from O the O Thematic B-ORG Excellence I-ORG Program I-ORG of I-ORG the I-ORG Ministry I-ORG for I-ORG Innovation I-ORG and I-ORG Technology I-ORG in I-ORG Hungary I-ORG TKP-2020-NKA-04 O within O the O framework O of O the O Space O Sciences O thematic O program O of O the O University O of O Debrecen O Z.M.K O was O supported O by O the O ÚNKP-22-3-II-DE-112 B-AWARD New O National O Excellence O Program O of O the O Ministry O for O Innovation O and O Technology O from O the O source O of O National B-ORG Research I-ORG Development I-ORG and I-ORG Innovation I-ORG Fund O A.F O was O supported O by O the O ÚNKP-22-3-II-DE-38 O New O National O Excellence O Program O of O the O Ministry O for O Innovation O and O Technology O from O the O source O of O National O Research O Development O and O Innovation O Fund O Funding O sources O had O no O involvement O in O the O preparation O of O the O article O in O the O study O design O in O the O collection O analysis O and O interpretation O of O data O in O the O writing O of O the O report O and O in O the O decision O to O submit O the O article O for O publication O This O research O was O funded O by O The B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U21A20251 O the B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Program I-ORG of I-ORG Jilin I-ORG Province I-ORG 20210202039NC O and O Jilin B-ORG University I-ORG “Student I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Training I-ORG Program” I-ORG 202210183337 O This O work O was O supported O by O Nanjing B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 201605004 O Nanjing B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Project I-ORG 201503010 O Nanjing B-ORG military I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 14MS098 O and O Foundation B-ORG of I-ORG Jinling I-ORG Hospital I-ORG of I-ORG Nanjing I-ORG University I-ORG 2015046 O SB O is O a O Wellcome B-ORG Trust I-ORG Senior O Investigator O grant O no. O 099232/z/12/z B-AWARD The O Balasubramanian O group O is O supported O by O a O European B-ORG Research I-ORG Council I-ORG Advanced O Grant O no. O 339778 B-AWARD and O receives O core O funding O C14303/A17197 O and O program O funding O C9681/A18618 O from O Cancer B-ORG Research I-ORG UK. I-ORG The O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81230015 O CAMS B-ORG Innovation I-ORG Found I-ORG for I-ORG Medical I-ORG Sciences I-ORG 2016-I2M-1-002 O the O Beijing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG Z151100003915078 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0905100 O to O Xue O Zhang O and O The O National O Natural O Science O Foundation O of O China O 81670896 O the O Liaoning B-ORG Provincial I-ORG Education I-ORG Department I-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Project I-ORG LK201653 O to O Lihua O Cao O This O work O was O supported O by O Independent B-ORG Innovation I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG in O Jiang O Su O Province O CX(15)1003 O Network B-ORG and I-ORG Technology I-ORG Served I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Program I-ORG STS I-ORG “Grassland O agricultural O system O construction O and O industrialization O demonstration O of O typical O village O Jina O village O in O Tibet” O KFJ-EW-STS-071 O and O the O National B-ORG Spark I-ORG Plan I-ORG Project I-ORG “Integration O and O demonstration O of O planting O high O quality O forage O grass O and O breeding O cows O healthily O technology” O 2013GA840003 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81972310 O 81672416 B-AWARD Major B-ORG Natural I-ORG Science I-ORG Reasearch I-ORG Project I-ORG for I-ORG Universities I-ORG in I-ORG Jiangsu I-ORG Province I-ORG 18KJA320001 O Key B-ORG Laboratory I-ORG of I-ORG Molecular I-ORG Diagnostics I-ORG and I-ORG Precision I-ORG Medicine I-ORG for I-ORG Surgical I-ORG Oncology I-ORG in I-ORG Gansu I-ORG Province I-ORG 2019GSZDSYS01 O and O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O This O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG international I-ORG cooperation I-ORG 81570184 O the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Nantong I-ORG City I-ORG MS22018008 O the O Science O and O Technology O Project O of O Nantong O City O MS12017003-2 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2019M660127 O Jiangsu B-ORG Province I-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2019K062 O Jiangsu B-ORG Province I-ORG Postdoctoral I-ORG Foundation I-ORG 2019Z146 O This O research O was O supported O in O part O by O research O grants O from O National B-ORG Institutes I-ORG of I-ORG Health I-ORG HG008146 O and O LM012487 B-AWARD Pennsylvania B-ORG Department I-ORG of I-ORG Health I-ORG TU-420721 O and O High O Performance O instrumentation O grants O from O National B-ORG Science I-ORG Foundation I-ORG 1625061 O and O US O Army B-ORG Research I-ORG Laboratory I-ORG W911NF-16-2-0189 O The O funders O had O no O direct O role O in O the O study O design O data O collection O analysis O or O writing O the O manuscript O This O research O was O funded O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFB1105700 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31530024 O 81672213 I-AWARD and I-AWARD 31872748 O Jiangsu B-ORG Provincial I-ORG Special I-ORG Program I-ORG of I-ORG Medical I-ORG Science I-ORG BL2012004 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2016M590500 O 2017T100398 O and O the O Priority O Academic O Program O Development O PAPD O of O Jiangsu O Higher O Education O Institutions O This O study O was O supported O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC1314002 O National B-ORG Natural I-ORG Scientific I-ORG Foundation I-ORG Grants I-ORG 81670696 B-AWARD Clinic B-ORG Research I-ORG Center I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grant I-ORG BL2014080 B-AWARD and O Postgraduate B-ORG Research I-ORG I-ORG Practice I-ORG Innovation I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG KYCX17_0173 O This O work O was O supported O by O the O Academy B-ORG for I-ORG Eating I-ORG Disorders I-ORG Student B-AWARD Research I-AWARD Grant I-AWARD HBM O the O American O Psychological O Association O Division O 38 O Graduate O Student O Research O Grant O HBM O the O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health—K23 O MH105680 I-AWARD ASJ O and O the O National B-ORG Institute I-ORG of I-ORG Diabetes I-ORG and I-ORG Digestive I-ORG and I-ORG Kidney I-ORG Diseases—K23DK124514 O SMM O This O work O was O supported O by O Chinese B-ORG Cassava I-ORG Agro-Technology I-ORG Research I-ORG System I-ORG CARS-11-YNSJ O Yunnan B-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Biological I-ORG Big I-ORG Data I-ORG 2018DG024 O and O the O Science B-ORG and I-ORG Technology I-ORG Plan I-ORG Projects I-ORG of I-ORG Yunnan I-ORG Province I-ORG 2016FD024 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 62174168 O 92164302 B-AWARD 62204251 B-AWARD 62274170 B-AWARD 91964204 B-AWARD the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDB44010200 O the O Science B-ORG and I-ORG Technology I-ORG Council I-ORG of I-ORG Shanghai I-ORG 22DZ2229009 O the O Shanghai B-ORG Pujiang I-ORG Program I-ORG 21PJ1415300 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 81071650 B-AWARD Special B-ORG foundation I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG in I-ORG Liaoning I-ORG Province I-ORG China I-ORG 2013225585 O Supporting B-ORG Project I-ORG for I-ORG Climbing I-ORG Scholars I-ORG in I-ORG Liaoning I-ORG Provincial I-ORG Universities I-ORG China I-ORG 2009 O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grants O 81801601 O 81671598 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG grant I-ORG 20ZR1451400 O Science B-ORG and I-ORG technology I-ORG commission I-ORG of I-ORG Shanghai I-ORG 20Y11911600 O the O Shanghai B-ORG Sailing I-ORG Program I-ORG 17YF1417200 O Clinical B-ORG research I-ORG program I-ORG of I-ORG Tongji I-ORG Hospital I-ORG Tongji I-ORG University I-ORG ITJZD1909 O ITJQN2001 O Shanghai B-ORG Pujiang I-ORG rheumatic I-ORG youth I-ORG cultivation I-ORG program I-ORG SPROG1810 O This O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81771313 O Beijing B-ORG Municipal I-ORG Natural I-ORG Science I-ORG Foundation I-ORG 7192040 O Beijing B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG “Capital O Characteristics” O Z171100001017039 O Beijing B-ORG Hospitals I-ORG Authority I-ORG Youth I-ORG Program I-ORG QML20150206 O Key B-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG the I-ORG People’s I-ORG Republic I-ORG of I-ORG China I-ORG 2016YFC0904502 O Key B-ORG Projects I-ORG of I-ORG Medical I-ORG Development I-ORG in I-ORG Capital I-ORG 2014-1-1101 O Beijing B-ORG Tongren I-ORG Hospital I-ORG Capital I-ORG Medical I-ORG University I-ORG Key I-ORG Medical I-ORG Development I-ORG Plan I-ORG TRYY-KYJJ-2017-054 O This O work O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Project I-ORG of I-ORG Hubei I-ORG Province I-ORG grant O number O 2022CFC022 B-AWARD the O Research O Project O of O Hubei B-ORG Administration I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG grant O number O ZY2023F060 B-AWARD Major O Clinical O Research O Project O of O Wuhan B-ORG Municipal I-ORG Health I-ORG Commission I-ORG grant O number O WG20M01 B-AWARD and O Research O Project O of O China B-ORG Plastic I-ORG and I-ORG Cosmetic I-ORG Association I-ORG grant O number O 2022)02049 B-AWARD This O work O was O partially O supported O by O DC O Technology O O Corporate O Venturing O of O Repsol O by O the B-ORG Argentinean I-ORG National I-ORG Council I-ORG of I-ORG Scientific I-ORG and I-ORG Technological I-ORG Research I-ORG CONICET O for O its O acronym O in O Spanish O Grants O PIP B-AWARD 11220210100600CO O PIBAA B-AWARD 28720210101236CO O and O PIBAA B-AWARD 2872021010048CO O by O the B-ORG National I-ORG Agency I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Research I-ORG Technological I-ORG Development I-ORG and I-ORG Innovation I-ORG of I-ORG Argentina I-ORG AGENCIA O I+D+i O in O Spanish O through O the O Fund O for O Scientific O and O Technological O Research O FONCyT O for O its O acronym O in O Spanish O Grants O PICT-2019-03350 B-AWARD and O PICT-PRH-2021-00008 B-AWARD by O the B-ORG Universidad I-ORG Nacional I-ORG del I-ORG Sur I-ORG UNS O Bahía O Blanca O Argentina O Grant O PGI B-AWARD 24/N042 O and O Ministerio B-ORG de I-ORG Economía I-ORG Industria I-ORG y I-ORG Competitividad I-ORG Gobierno I-ORG de I-ORG España I-ORG under O Grant O RTI2018-096100B-100 B-AWARD This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31872329 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2014A030312011 O and O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangzhou I-ORG 201804020039 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O grants O from O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Taiwan I-ORG MOST O 106-2320-B-038-012 I-AWARD and O MOST B-AWARD 107-2320-B-038-035-MY2 O Taipei B-ORG Medical I-ORG University I-ORG DP2-108-21121-01-N-02-03 O Chi-Mei B-ORG Medical I-ORG Center-Taipei I-ORG Medical I-ORG University I-ORG 106CM-TMU-03 O and O Cathay B-ORG General I-ORG Hospital I-ORG CGH-MR-A10720 O were O supported O to O this O study O This O study O was O supported O by O grants O from O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81573759 O 31771511 B-AWARD and O 82074261 O the O Talents B-ORG Training I-ORG Program I-ORG of I-ORG Seventh I-ORG People’s I-ORG Hospital I-ORG of I-ORG Shanghai I-ORG University I-ORG of I-ORG TCM I-ORG XX2018-07 O the O Summit B-ORG Discipline I-ORG of I-ORG Clinical I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG in I-ORG Pudong I-ORG New I-ORG Area I-ORG of I-ORG Shanghai I-ORG PDZY-2018-0601 O and O the B-ORG Innovation I-ORG Fund I-ORG for I-ORG College I-ORG Students I-ORG of I-ORG Second I-ORG Military I-ORG Medical I-ORG University I-ORG FH2017182 O This O project O received O funding O from O the O Chinese B-ORG National I-ORG Nature I-ORG Science I-ORG Foundation I-ORG Project O number O 81371069 B-AWARD Shanghai B-ORG Pujiang I-ORG Program I-ORG Project O number O PJ(2012 B-AWARD 0001652 O Shanghai B-ORG New I-ORG Hundred I-ORG Talents I-ORG Program I-ORG from I-ORG Shanghai I-ORG Medical I-ORG and I-ORG Family I-ORG Planning I-ORG Committee I-ORG Project O number O 13B141 B-AWARD Shanghai B-ORG Leading I-ORG Talent I-ORG Reserve I-ORG Program I-ORG 40311 O and O the B-ORG Projects I-ORG of I-ORG Shanghai I-ORG Shen I-ORG Kang I-ORG Hospital I-ORG Development I-ORG Center I-ORG SHDC12012123 O SHDC12015315 I-AWARD SHDC2015644 O The O funders O had O no O role O in O the O design O data O collection O data O analysis O data O interpretation O or O writing O of O this O report O This O study O was O sponsored O by O the B-ORG interdisciplinary I-ORG medicine I-ORG Seed I-ORG Fund I-ORG of I-ORG Peking I-ORG University I-ORG and I-ORG the I-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O Numbers O BMU2018MX001 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O Grant O Numbers O 81874321 B-AWARD and O 81673459 B-AWARD National B-ORG Key I-ORG Technologies I-ORG R&D I-ORG Program I-ORG Grant O Numbers O 2015BAK45B01 B-AWARD 2012BAK25B01 B-AWARD and O a O grant O from O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG – I-ORG Canadian I-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG NSFC-CIHR O China-Canada O Joint O Health O Research O Initiative O Grant O Numbers O 81061120525 B-AWARD and O CCI-109605 O This O work O was O supported O by O the O Collaboration O for O AIDS B-ORG Vaccine I-ORG Discovery I-ORG CAVD I-ORG funded O by O the O Bill O O Melinda O Gates O Foundation O Grant O O 38619 B-AWARD Global O HIV O Vaccine O Enterprise O GHVE O Central O Service O Facilities O CSFs O especially O Dr O D O Montefiori’s O Vaccine B-ORG Immune I-ORG Monitoring I-ORG Center I-ORG VIMC O Grant O O 383-0920 B-AWARD This O work O was O partially O supported O by O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG do I-ORG Rio I-ORG de I-ORG Janeiro—FAPERJ I-ORG grant O number O E26/110.517/2012 B-AWARD Monick O Lindenmeyer O Guimarães O is O recipient O of O a O CNPq O Fellowship O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O partly O supported O by O the O H2020 B-ORG Humane-AI-Net I-ORG project O grant O No. O 952026 B-AWARD CHIST-ERA B-ORG grant O No. O CHIST-ERA-19-XAI-010-MUR-484-22 B-AWARD and O by O the O European B-ORG Union I-ORG under I-ORG the I-ORG Italian I-ORG National I-ORG Recovery I-ORG and I-ORG Resilience I-ORG Plan I-ORG NRRP I-ORG of I-ORG partnership I-ORG on I-ORG “Artificial I-ORG Intelligence I-ORG Foundational I-ORG Aspects” I-ORG PE0000013-program O “FAIR” O The O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31360527 B-AWARD a O grant O from O Xinjiang B-ORG Key I-ORG Laboratory I-ORG of I-ORG Biological I-ORG Resources I-ORG and I-ORG Genetic I-ORG Engineering I-ORG No.XJDX0201-2014-03 O and O the O Tianshan B-ORG Cedar I-ORG Project I-ORG in O 2017 B-AWARD 2017xs20 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31760244 B-AWARD 31700338 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG No.1610322019012 O the O Innovation B-ORG Project I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG No. O CAAS-XTCX2016011-02 B-AWARD the O Science B-ORG and I-ORG technology I-ORG innovation I-ORG project I-ORG of I-ORG Gansu I-ORG Agricultural I-ORG University I-ORG No. O GAU-XKJS-2018-112 B-AWARD and O Gansu B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Projects I-ORG No. O 19ZD2NA002 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Cultivating B-ORG funding I-ORG by I-ORG Zhejiang I-ORG Medical I-ORG and I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project O grant O number O 2023KY593 B-AWARD the O Cancer B-ORG Hospital I-ORG of I-ORG the I-ORG University I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences O grant O number O PY2021025 B-AWARD the B-ORG Medicine I-ORG and I-ORG Health I-ORG Discipline I-ORG Platform I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province O grant O number O 2018RC019 B-AWARD the B-ORG Medicine I-ORG and I-ORG Health I-ORG Science I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province O grant O number O 2020KY483 B-AWARD Natural B-ORG Science I-ORG Funds I-ORG of I-ORG Shanghai O grant O numbers O 21ZR1413800 B-AWARD and O 22ZR1400100 B-AWARD and O Shanghai O Municipal O Key O Clinical O Specialty O grant O number O shslczdzk02401 O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG No. O 2013CB127100 B-AWARD Fundamental O Research O Funds O for O the O Central O Universities O No. O CDJZR14295501 O Chongqing B-ORG Frontier I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG No. O CSTC2014JCYJA80012 B-AWARD the O Open O Project O Funding O of O State O Key O Laboratory O of O Cotton O Biology O No. O CB2014A08 O and O CB2015A14 O Promote O Scientific O Research O and O Cooperation O and O High O level O Personnel O Training O Project O in O America O and O Oceania O supported O by O Ministry O of O Education O No. O 0903005109094/003 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31200903 B-AWARD Funding O for O this O work O came O from O the B-ORG “333 I-ORG Project” I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG of I-ORG China I-ORG Grant O no. O BRA2014132 B-AWARD the B-ORG Major I-ORG research I-ORG projects I-ORG in I-ORG maternal I-ORG and I-ORG child I-ORG health I-ORG care I-ORG of I-ORG Jiangsu I-ORG Provincial I-ORG Department I-ORG of I-ORG Health I-ORG Grant O no. O F201214 B-AWARD and O the B-ORG Development I-ORG Program I-ORG for I-ORG Technological I-ORG Innovation I-ORG and I-ORG Platform I-ORG Construction I-ORG of I-ORG HuaiAn I-ORG Award O No O HAP201016 B-AWARD HL O is O employed O by O CapitalBio O Genomics O Co O Ltd O CY O is O employed O by O BGI-Shenzhen O CapitalBio O Genomics O Co O Ltd O and O BGI-Shenzhen O provided O support O in O the O form O of O salaries O for O authors O HL O and O CY, O but O did O not O have O any O additional O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O specific O roles O of O these O authors O are O articulated O in O the O ‘author O contributions’ O section O The O present O work O was O supported O by O grants O PI15/00619 B-AWARD and O PI19/00778 B-AWARD to O A.J.J O and O P.P.-G O PI21/000914 B-AWARD to O J.V O and O PI21/000915 B-AWARD to O A.G O from O the O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III O Spain O co-financed O by O FEDER O funds I-ORG from I-ORG the I-ORG European I-ORG Union O PI18-RT-2233 B-AWARD from O Junta O de O Andalucía O to O A.G O co-financed O by O Programa B-ORG Operativo I-ORG FEDER I-ORG 2014–2020 O PID2020-115218RB-I00 B-AWARD to O T.I O funded O by O MCIN/AEI/10.13039/501100011033 B-AWARD Centro B-ORG de I-ORG Investigación I-ORG Biomédica I-ORG en I-ORG Red I-ORG de I-ORG Enfermedades I-ORG Neurodegenerativas I-ORG CIBERNED O Instituto O de O Salud O Carlos O III O Spain O to O J.V O T.I O and O A.G O FPU13/02906 B-AWARD to O MG-B O from O the O Ministerio B-ORG de I-ORG Educación I-ORG Cultura I-ORG y I-ORG Deporte O Spain O RYC-2014-16980 B-AWARD to O P.P.-G O from O the O Ministerio B-ORG de I-ORG Economía I-ORG y I-ORG Competitividad O Spain O UMA18-FEDERJA-277 B-AWARD from O Plan B-ORG Operativo I-ORG FEDER I-ORG Andalucía I-ORG 2014–2020 O and O Universidad O de O Málaga O to O P.P.-G O Proyectos O dirigidos O por O jóvenes O investigadores O from O Universidad O de O Málaga O to O P.P.-G O The O cost O of O this O publication O has O been O paid O in O part O by O “ERDF O A O way O of O making O Europe” O funds O This O research O was O funded O by O NIAID/NIH B-ORG Grant O U19 B-AWARD AI068021 O BAA/NIAID B-ORG grant O 1R1AI157357 B-AWARD NIH O grant O R01CA260900 B-AWARD and O STTR/NIAID B-ORG 75N93021C00008 B-AWARD This O work O was O financially O supported O by O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 21273160 B-AWARD the O Nature B-ORG Science I-ORG Foundation I-ORG of I-ORG Tianjin I-ORG grant O no. O 14JCYBJC18000 B-AWARD and O the O Program B-ORG for I-ORG Innovative I-ORG Research I-ORG Team I-ORG in I-ORG the I-ORG University I-ORG of I-ORG Tianjin I-ORG TD13-5074 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41501259 O Shanghai B-ORG Sailing I-ORG Program I-ORG 18YF1420900 O the O SAAS B-ORG Program I-ORG for I-ORG Excellent I-ORG Research I-ORG Team I-ORG nong O ke I-AWARD chuang I-AWARD 2017 I-AWARD A-03 O Shanghai B-ORG Agriculture I-ORG Applied I-ORG Technology I-ORG Development I-ORG Program I-ORG T20170105 O the O Key B-ORG Agricultural I-ORG Technology I-ORG Program I-ORG of I-ORG Shanghai I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG 16391901500 O Domestic B-ORG Cooperation I-ORG program I-ORG of I-ORG Shanghai I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG 18295810500 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Ministry B-ORG of I-ORG Education I-ORG of I-ORG the I-ORG People’s I-ORG Republic I-ORG of I-ORG China I-ORG under O Grant O 14YJCZH010 O MC O Soft B-ORG Science I-ORG of I-ORG Science I-ORG Technology I-ORG Department I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2017C35056 O MC O Soft B-ORG Science I-ORG Fund I-ORG of I-ORG Hangzhou I-ORG Science I-ORG and I-ORG Technology I-ORG Committee I-ORG under I-ORG Grant I-ORG 20150834M35 O MC O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under I-ORG Grant I-ORG 31400607 O YS O Work O in O our O laboratory O is O supported O by O the O Spanish B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Innovation I-ORG BFU2011-27568 O Spanish B-ORG Ministry I-ORG of I-ORG Economy I-ORG and I-ORG Competitively I-ORG BFU2013-43132-P O and O BFU2016-77975-R B-AWARD AEI/FEDER O UE O cofounded O by O FEDER O funds/European O Regional O Development O Fund O a O way O to O build O Europe O MRL O was O supported O by O the O Lundbeck O foundation O Junior O Group O Leader O Fellowship O This O work O was O supported O by O a O generous O grant O from O the O VILLUM O Foundation O to O the O VILLUM O Centre O for O Bioanalytical O Sciences O at O the O University O of O Southern O Denmark O SBB O is O a O recipient O of O ISCIII B-ORG grant O 13FIS037 B-AWARD IDIBELL B-ORG Proteomics O Unit O belongs O to O ProteoRed O PRB2-ISCIII O and O is O supported O by O grant O PT13/0001/0033 B-AWARD This O work O was O supported O by O grants O from O the O Min-Sheng B-ORG General I-ORG Hospital I-ORG Taoyuan I-ORG and I-ORG Taiwan I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG MOST O 104-2314-B-010-005 O as O well O as O the O Cheng B-ORG Hsin I-ORG General I-ORG Hospital-National I-ORG Yang-Ming I-ORG University I-ORG Joint I-ORG Research I-ORG Program I-ORG CY10517 O CY10618 B-AWARD and O CY10717 B-AWARD to O Chun O Yeh O and O Chih-Yen O Chen O and O Far B-ORG Eastern I-ORG Memorial I-ORG Hospital-National I-ORG Yang-Ming I-ORG University I-ORG Joint I-ORG Research I-ORG Program I-ORG 105DN15 O 106DN15 B-AWARD and O 107DN14 B-AWARD to O Tzong-Hsi O Lee O and O Chih-Yen O Chen O Taipei O Taiwan O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O authors O greatly O appreciate O the O financial O support O of, O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51902282 B-AWARD 11474246 I-AWARD 51772258 I-AWARD and I-AWARD 21603182 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O BK20160434 B-AWARD and I-AWARD BK20160061 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG No. O 2016YFC0209202 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2018M632283 B-AWARD Industry–University–Research O Collaboration O Project O of O Jiangsu O Province O No. O BY2018281 O Joint O Open O Fund O of O Jiangsu O Collaborative O Innovation O Center O for O Ecological O Building O Material O and O Environmental O Protection O Equipments O and O Key O Laboratory O for O Advanced O Technology O in O Environmental O Protection O of O Jiangsu O Province O No. O JH201808 O and O Open O Project O of O Key O Laboratory O for O Ecological-Environment O Materials O of O Jiangsu O Province O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31301656 O 31371947 B-AWARD the O National B-ORG Department I-ORG of I-ORG Public I-ORG Benefit I-ORG Research I-ORG Project I-ORG of I-ORG China I-ORG 201303057 O 201403031 B-AWARD and O the O International B-ORG Science I-ORG I-ORG Technology I-ORG Cooperation I-ORG Program I-ORG of I-ORG China I-ORG 2014DFR31250 O The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O fully O supported O by O the O National B-ORG Center I-ORG for I-ORG Genetic I-ORG Engineering I-ORG and I-ORG Biotechnology I-ORG BIOTEC O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Agency I-ORG NSTDA O Thailand O under O the O Ri-BIOTEC B-ORG program I-ORG grant O number O P-16-51098 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Jiangsu B-ORG Key I-ORG Project I-ORG of I-ORG Graduate I-ORG Education I-ORG Reform I-ORG Project O Number O JGZD18_012 B-AWARD Graduate B-ORG Education I-ORG Teaching I-ORG Reform I-ORG Project I-ORG of I-ORG Nanjing I-ORG Medical I-ORG University I-ORG SPOCZD201902 O and O Jiangsu B-ORG Province I-ORG Graduate I-ORG Education I-ORG Teaching I-ORG Reform I-ORG Research I-ORG and I-ORG Practice I-ORG JGLX14071 O None O of O the O funding O providers O contributed O to O the O content O or O writing O of O this O article O The O input O of O P.S O contributes O to O the O following O projects O DEVIL B-AWARD NE/M021327/1 I-AWARD MAGLUE I-AWARD EP/M013200/1 I-AWARD U-GRASS I-AWARD NE/M016900/1 O Assess-BECCS O funded O by O UKERC B-ORG and O Soils-R-GRREAT B-ORG NE/P019455/1 B-AWARD A.M O is O supported O by O a O BBSRC O EastBio O studentship O J.P O was O supported O by O the O EU B-ORG FP7 I-ORG HELIX I-ORG project I-ORG grant O agreement O number O 603864 B-AWARD Climate O data O used O in O the O biodiversity O analysis O were O produced O during O the O Avoiding O Dangerous O Climate O Change O project O funded O by O the O former O UK O Department O of O Energy O and O Climate O Change O Financial O support O for O this O research O was O provided O by O the B-ORG earmarked I-ORG fund I-ORG for I-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-27 O National B-ORG Key I-ORG Technology I-ORG R&D I-ORG Program I-ORG 2013BAD02B01-4 O 2014BAD16B03 O and O grants O from O the O Beijing B-ORG Municipal I-ORG Education I-ORG Commission I-ORG CEFF-PXM2017_014207_000043 O This O work O was O supported O by O grants O from O the O Oversea B-ORG Visiting I-ORG Scholar I-ORG Program I-ORG in I-ORG Shanghai I-ORG University I-ORG of I-ORG Sport I-ORG stfx20160103 O Innovation B-ORG and I-ORG Creativity I-ORG Training I-ORG Program I-ORG for I-ORG Graduate I-ORG Students I-ORG in I-ORG Shanghai I-ORG University I-ORG of I-ORG Sport I-ORG yjscx2015022 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31371056 O 31470051 B-AWARD Shanghai B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG ZHYY-ZXYJHZX-2-22 O Shanghai B-ORG Key I-ORG Lab I-ORG of I-ORG Human I-ORG Performance I-ORG Shanghai I-ORG University I-ORG of I-ORG Sport I-ORG 11DZ2261100 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Hui-Juan O Cao O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81804000 O and O the O Beijing B-ORG Municipal I-ORG Organization I-ORG Department I-ORG 2017000020124G292 O Jian-Ping O Liu O is O supported O by O the B-ORG Key I-ORG project I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81830115 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O paper O is O funded O by O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Air I-ORG Traffic I-ORG Management I-ORG System I-ORG and I-ORG Technology O NO: O SKLATM201704 B-AWARD YZ O National B-ORG Key I-ORG Research I-ORG Program I-ORG of I-ORG China O NO: O 2016YFB0502400 B-AWARD YZ O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O NO: O U1633112 B-AWARD U1533112 I-AWARD YZ O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O mainly O supported O by O grants O from O the O National B-ORG Nature I-ORG Science I-ORG Funds I-ORG of I-ORG China I-ORG grant O no. O 81772964 B-AWARD the O Special B-ORG Scientific I-ORG Research I-ORG Fund I-ORG of I-ORG Public I-ORG Welfare I-ORG Profession I-ORG of I-ORG National I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG grant O no. O 201502026 B-AWARD and O the O Guangdong B-ORG Gastrointestinal I-ORG Disease I-ORG Research I-ORG Center I-ORG grant O no. O 2017B020209003 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 81571645 B-AWARD the O Sichuan B-ORG Province I-ORG Special I-ORG Project I-ORG for I-ORG Youth I-ORG Team I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG grant O no. O 2015TD0029 B-AWARD and O the O Construction B-ORG Plan I-ORG for I-ORG Scientific I-ORG Research I-ORG Team I-ORG of I-ORG Sichuan I-ORG Provincial I-ORG Colleges I-ORG and I-ORG Universities I-ORG grant O no. O 15TD0023 B-AWARD This O study O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Grants O LGJ18H310002 B-AWARD and O LQY19H090001 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31900381 B-AWARD and O 31870080 B-AWARD the O Medical B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. O 2020388156 B-AWARD the O Youth B-ORG start-up I-ORG fund I-ORG of I-ORG Second I-ORG Military I-ORG Medical I-ORG University I-ORG Grant O No. O 2018QN13 B-AWARD and O the O Innovation B-ORG Training I-ORG Program I-ORG of I-ORG Anhui I-ORG No. O 201810368117 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the O National B-ORG Key I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2015BAD03B05 O the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-38 O and O the O Program B-ORG for I-ORG Changjiang I-ORG Scholars I-ORG and I-ORG Innovative I-ORG Research I-ORG Team I-ORG in I-ORG University I-ORG IRT13019 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O Shandong B-ORG key I-ORG research I-ORG and I-ORG development I-ORG programs I-ORG No. O 2018GSF118048 B-AWARD National B-ORG key I-ORG research I-ORG and I-ORG development I-ORG programs I-ORG of I-ORG China I-ORG No. O 2017YFC0113202 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81472811 B-AWARD and O Shandong O key O research O and O development O programs O No. O 2018GSF118006 B-AWARD This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 11774279 B-AWARD 11774280 B-AWARD the O National B-ORG Science I-ORG Fund I-ORG for I-ORG Outstanding I-ORG Young I-ORG Scholars I-ORG No. O 11922410 B-AWARD and O the O Open B-ORG Project I-ORG Program I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Cancer I-ORG Biology I-ORG CBSKL2022ZDKF07 O This O study O was O financially O supported O by O Chinese B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Nos O 31760028 B-AWARD and I-AWARD 31460032 O the O Fundamental O Research O Funds O for O Key B-ORG Laboratory I-ORG of I-ORG Drug I-ORG Screening I-ORG and I-ORG Deep I-ORG Processing I-ORG for I-ORG Traditional I-ORG Chinese I-ORG and I-ORG Tibetan I-ORG Medicine I-ORG of O Gansu O Province O No. O KZZY20180605 B-AWARD and O the O Youth O Talent O Support O Program O of O Lanzhou B-ORG University I-ORG of I-ORG Technology I-ORG No. O 2018 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O sponsored O from O the B-ORG Project I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Funding I-ORG of I-ORG China I-ORG Grant O No. O 81472207 B-AWARD the B-ORG Special I-ORG Fund I-ORG for I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG from I-ORG the I-ORG National I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG PRC I-ORG Grant O No. O 201402031 B-AWARD Key B-ORG Lab I-ORG System I-ORG Project I-ORG of I-ORG Guangdong I-ORG Science I-ORG and I-ORG Technology I-ORG Department–Guangdong I-ORG Provincial I-ORG Key I-ORG Lab I-ORG of I-ORG Translational I-ORG Medicine I-ORG in I-ORG Lung I-ORG Cancer I-ORG Grant O No. O 2012A061400006/2017B030314120 B-AWARD Research B-ORG Funds I-ORG from I-ORG the I-ORG Guangzhou I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG Grant O No. O 201607010391 B-AWARD and I-AWARD 2016B020237006 O These O funding O were O involved O in O the O study O design O interpretation O of O the O data O and O preparation O of O the O manuscript O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 52176076 B-AWARD 51676103 B-AWARD Taishan B-ORG Scholar I-ORG Project I-ORG of I-ORG Shandong I-ORG Province I-ORG China O No.ts20190937 O and O the O Open B-ORG Fund I-ORG of I-ORG Shandong I-ORG Smart I-ORG Green I-ORG Manufacturing I-ORG Technology I-ORG and I-ORG Equipment I-ORG Collaborative I-ORG Innovation I-ORG Center I-ORG No. O IGSD-2020-013 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Funds I-ORG for I-ORG Young I-ORG Scholars I-ORG of I-ORG China I-ORG Grant O 52206173 B-AWARD 51806033 B-AWARD Foundation B-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG High-efficiency I-ORG Utilization I-ORG of I-ORG Coal I-ORG and I-ORG Green I-ORG Chemical I-ORG Engineering I-ORG Grant O 2022-K44 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG Grant O E202203192 B-AWARD and O Hebei B-ORG Province I-ORG Department I-ORG of I-ORG Education I-ORG Grant O QN2022101 B-AWARD The O present O study O was O supported O by O grants O from O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG No. O 2019YFA0905600 B-AWARD Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Tianjin I-ORG China I-ORG No.19YFSLQY00110 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Tianjin I-ORG China I-ORG No. O 19JCTPJC40900 B-AWARD This O work O was O supported O by O grants O to O YNS O from O the B-ORG Medical I-ORG Development I-ORG Project I-ORG of I-ORG Nanjing I-ORG Science I-ORG Committee I-ORG YKK12085 O and O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81401620 O and O grant O to O HGB O from O Jiangsu B-ORG Provincial I-ORG Special I-ORG Program I-ORG of I-ORG Medical I-ORG Science I-ORG BL2014012 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O is O supported O jointly O by O the B-ORG National I-ORG Key I-ORG Research I-ORG Project I-ORG of I-ORG China I-ORG “13th I-ORG Five I-ORG Year I-ORG Plan” I-ORG No. O 2016YFC0400202 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 41807041 O No. B-AWARD 41831284 O No. B-AWARD 51679205 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2018A0303130149 B-AWARD Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG No.20181002SF0530 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG GK201903115 O and O the B-ORG Program I-ORG of I-ORG Introducing I-ORG Talents I-ORG of I-ORG Discipline I-ORG to I-ORG Universities I-ORG B16011 O The O funding O bodies O were O not O involved O in O the O design O of O the O study O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O The O work O was O supported O by O grants O provided O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81570810 O and O the O Technology B-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BL2014085 O This O work O was O also O supported O by O a O Project B-ORG funded I-ORG by I-ORG Jiangsu I-ORG Province I-ORG Health I-ORG Commission I-ORG H201402 O This O study O was O supported O by O the B-ORG Special I-ORG Fund I-ORG for I-ORG Agro-Scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG 201303046 O Program B-ORG for I-ORG Independence I-ORG and I-ORG Innovation I-ORG in I-ORG Agricultural I-ORG Sciences I-ORG of I-ORG Jiangsu I-ORG Province I-ORG CX(12)3061 O and O CX(14)2084 O and O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20131334 O This O work O was O supported O by O several O grants O Science B-ORG Foundation I-ORG Ireland I-ORG 12/TIDA/B2265 B-AWARD The O European B-ORG Respiratory I-ORG Society/GlaxoSmithKline O Rare B-AWARD Disease I-AWARD Award I-AWARD 2013 I-AWARD and O Ministero B-ORG della I-ORG Salute-Bando O Ricerca O Finalizzata O 2009 O RF-2009-1529895 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O a O grant O from O the B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG Shanxi I-ORG Province I-ORG Grant O No.201803D31062 O the B-ORG Program I-ORG for I-ORG the I-ORG Top I-ORG Young I-ORG Innovative I-ORG Talents I-ORG of I-ORG Shanxi I-ORG Agricultural I-ORG University I-ORG Grant O No. O TYIT201403 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 31402156 B-AWARD and O 31873002 B-AWARD Please O add O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O 31702121 B-AWARD the O 111 B-ORG Project O B16044 B-AWARD and O Chinese B-ORG Universities I-ORG Scientific I-ORG Fund O 2019TC120 B-AWARD The O different O parts O of O this O study O were O independently O funded O by O grants O to O A.P O from O Duchenne B-ORG Parent I-ORG Project I-ORG Spain O DPP-E O 2018 O Catalan O Agency B-ORG for I-ORG Management I-ORG of I-ORG University I-ORG and I-ORG Research I-ORG Grants I-ORG AGAUR O 2014-SGR-475 O and O 2017-SGR-1174 B-AWARD Ministry B-ORG of I-ORG Economy I-ORG and I-ORG Competitiveness I-ORG SAF2014-52874-R O and O SAF2017-84918-R B-AWARD National B-ORG Scientific I-ORG and I-ORG Technical I-ORG Research I-ORG and I-ORG Innovation I-ORG 2013-2016 B-AWARD and O 2017-2020 B-AWARD Plans O which O are O co-financed O by O the O European O Regional O Development O Fund O of O the O European O Union O Commission O Avon O Foundation O SAU O AVFSAU O The O IDIBAPS O Institute O is O partly O funded O by O the O CERCA O Program O of O Generalitat O de O Catalunya O CN O was O subsequently O funded O by O a O Unipharma O Graduates-10 O visiting O scholarship O by O the O Noopolis O Foundation O and O Sapienza O University O of O Rome O financed O by O European O Union O Program O “Leonardo O da O Vinci” O and O a O PhD O scholarship O from O AGAUR O AGAUR-2015-FI_B-00121 O and O was O later O supported O by O SAF2014-52874-R O to O AP O LS O was O supported O by O grants O AVFSAU O and O SAF2014-52874-R O to O AP O Funding O for O open O access O charge O Catalan O Agency O for O Management O of O University O and O Research O Grants O AGAUR O 2017-SGR-1174 O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81473038 B-AWARD Taizhou B-ORG City I-ORG Science I-ORG Program I-ORG grant O number O 1401KY49 B-AWARD Shanghai B-ORG 3-Year I-ORG Public I-ORG Health I-ORG Action I-ORG Plan I-ORG grant O number O GWTD2015S04 B-AWARD and O Shanghai B-ORG Leading I-ORG Academic I-ORG Discipline I-ORG Project I-ORG of I-ORG Public I-ORG Health I-ORG grant O number O 15GWZK0801 B-AWARD The O sponsors O have O no O role O in O the O study O design O survey O process O data O analysis O and O manuscript O preparation O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 62003232 B-AWARD No. O 52275568 B-AWARD and O No. O 62031022 B-AWARD the O Shanxi B-ORG Provincial I-ORG Key I-ORG Medical I-ORG Scientific I-ORG Research I-ORG Project I-ORG 2020XM06 O the O Shanxi B-ORG Provincial I-ORG Basic I-ORG Research I-ORG Project I-ORG No. O 202103021221006 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Yunnan I-ORG Province I-ORG Grant O No. O 202201AY070001-287 B-AWARD This O study O was O supported O by O the O Key O Program O of O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31330079 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Henan I-ORG Province I-ORG 162300410129 O the O Key B-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG Specific I-ORG Projects I-ORG 2012ZX10004220-001 O and O the O Natural O Science O Foundation O of O China O U1404327 O This O work O was O financially O supported O in O part O by O grants O from O the O Shanxi B-ORG Normal I-ORG University I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG and I-ORG Application I-ORG Fund I-ORG YK1502 O Shanxi B-ORG Province I-ORG key I-ORG research I-ORG and I-ORG development I-ORG programs I-ORG Fund I-ORG 201703D221026-1 O and O the O Basic B-ORG Research I-ORG Project I-ORG of I-ORG Shanxi I-ORG Province I-ORG 201701D221169 O The O funders O had O no O role O in O study O design O date O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Cancer B-ORG Research I-ORG UK I-ORG A25922 O the O Medical B-ORG Research I-ORG Council I-ORG G1000508 O and O the O Wellcome B-ORG Trust I-ORG through O the O Centre B-AWARD for I-AWARD Chronic I-AWARD Diseases I-AWARD and I-AWARD Disorders I-AWARD C2D2 I-AWARD and I-AWARD Centre I-AWARD for I-AWARD Future I-AWARD Health I-AWARD CFH I-AWARD at O the O University O of O York O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31371570)http://www.nsfc.gov.cn O received O by O Gui O Cou O Cao O State B-ORG Key I-ORG Special I-ORG Program I-ORG 2017YFD0301400 O to O Gui O Cou O Cao O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2662017JC007 O to O Yang O Jiang O National O Natural O Science O Foundation O of O China O 31701359 O to O Yang O Jiang O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017M612477 O to O Yang O Jiang O and O National O Program O of O Transgenic O Variety O Development O of O China O 2014ZX08001-001)http://www.nmp.gov.cn O received O by O Gui O Cou O Cao O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the O Czech B-ORG Science I-ORG Foundation I-ORG GACR O P506/12/1046 O and O by O the O project O BIOCEV B-ORG CZ.1.05/1.1.00/02.0109 O and O National O Program O for O Sustainability O II O LQ1604 O from O the O Ministry B-ORG of I-ORG Education I-ORG Youth I-ORG and I-ORG Sports O BK O was O supported O from O a O student O grant O SVV B-ORG 260 B-AWARD 434 I-AWARD I-AWARD 2017 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O the O Key B-ORG Project I-ORG of I-ORG Yunnan I-ORG Education I-ORG Department O 2015Z073 B-AWARD Yue-Mei O Feng O data O collection O and O analysis O Applied B-ORG Basic I-ORG Research I-ORG Key I-ORG Project I-ORG of I-ORG Yunnan O 2014FZ008 B-AWARD Jianzhong O Yin O decision O to O publish O Yunnan B-ORG provincial I-ORG innovation I-ORG team I-ORG project O 2015HC030 B-AWARD Xueshan O Xia O preparation O of O the O manuscript O and O National B-ORG key I-ORG R&D I-ORG Program I-ORG of I-ORG China O 2017YFC0907302 B-AWARD Jianzhong O Yin O data O collection O and O analysis O This O work O was O supported O by O endowed O funds O from O the O Government O of O Canada O through O Genome O Canada O and O the O Ontario B-ORG Genomics I-ORG Institute I-ORG OGI-121 O A O Kid’s O Brain O Tumor O Cure O Brain O Tumour O Research O Assistance O and O Information O Network O The O Pediatric O Low-Grade O Astrocytoma O Foundation O Meagan’s O Walk O B.r.a.i.n.child O Canada O Canadian B-ORG Cancer I-ORG Society I-ORG Grant O O 702296 B-AWARD Canadian B-ORG Institute I-ORG of I-ORG Health I-ORG Research I-ORG Grant O O 159805 B-AWARD S. O R O holds O awards O from O Restracomp O Scholarship O and O Fellowship O funds O from O the O Garron O Family O Chair O in O Childhood O Cancer O Research O at O The O Hospital O for O Sick O Children O Canadian O Institute O of O Health O Research O CGS-M O scholarship O Ontario O Graduate O Scholarship O This O research O was O funded O by O National B-ORG Social I-ORG Science I-ORG Foundation I-ORG of I-ORG China O 22BXW048 B-AWARD the O Ministry B-ORG of I-ORG Education I-ORG of I-ORG Humanities I-ORG and I-ORG Social I-ORG Science I-ORG Project I-ORG of I-ORG China O 20YJA880023 B-AWARD and O “Double B-ORG Major” I-ORG cultivation I-ORG projects I-ORG of I-ORG Sichuan I-ORG Normal I-ORG University O 2021-SZPY-04 B-AWARD This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31670342 O the O Strategic O Priority O Research O Program O of O the O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG grant O no. O XDB31000000 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Plan I-ORG of I-ORG Yunnan I-ORG 2018BB010 O The O study O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2020YFA0908300 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 22178024 O and O the O Open B-ORG Funding I-ORG Project I-ORG of I-ORG the I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Biochemical I-ORG Engineering I-ORG No. O 2020KF-05 O The O research O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31301623 O and O 31300128 O Jiangsu B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG BK20130704 O and O Jiangsu B-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Fund I-ORG CX(13)5050 O to O Xin O Liu O and O Special B-ORG Fund I-ORG for I-ORG Agro-scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG 201303016 O to O Jianrong O Shi O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 91951210 B-AWARD the O Laboratory B-ORG for I-ORG Marine I-ORG Biology I-ORG and I-ORG Biotechnology I-ORG OF2019NO06 O the O Pilot B-ORG National I-ORG Laboratory I-ORG for I-ORG Marine I-ORG Science I-ORG and I-ORG Technology I-ORG Qingdao I-ORG and I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 92251303 B-AWARD J.W O acknowledges O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2021M702086 B-AWARD This O work O was O funded O by O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG ASTIP O CAAS-ASTIP O the B-ORG Central I-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG 1610192017709 O the B-ORG Earmarked I-ORG Fund I-ORG for I-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-29 B-AWARD and O the B-ORG Science-Technology I-ORG Project I-ORG of I-ORG Henan I-ORG province I-ORG 172102110244 O Shenzhen B-ORG Municipal I-ORG Government I-ORG JCYJ20160324163734374 O JCYJ20170413113448742 B-AWARD 20151030A0610001 B-AWARD Key O Project O of O Zhejiang B-ORG Province I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2015C03055 O Key O Project O of O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81730108 O Funding O for O open O access O charge O The O above O acknowledged O fundings O will O pay O for O the O publication O charges O This O work O is O supported O by O Graduate B-ORG Innovation I-ORG Fund I-ORG of I-ORG Jilin I-ORG University I-ORG No. O 2016031 B-AWARD The B-ORG National I-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61373051 B-AWARD No. O 61502343 B-AWARD No. O 61772226 B-AWARD and O No. O 61702214 B-AWARD Science B-ORG and I-ORG Technology I-ORG Development I-ORG Program I-ORG of I-ORG Jilin I-ORG Province I-ORG No. O 20140204004GX B-AWARD The B-ORG Science I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Guangxi I-ORG Universities I-ORG No. O KY2015ZD122 B-AWARD The B-ORG Science I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Wuzhou I-ORG University I-ORG 2014A002 O Project O of O Science O and O Technology O Innovation O Platform O of O Computing O and O Software O Science O 985 O Engineering O The O Key O Laboratory O for O Symbol O Computation O and O Knowledge O Engineering O of O the O National O Education O Ministry O of O China O The O Fundamental O Research O Funds O for O the O Central O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2014M561293 B-AWARD Development B-ORG Project I-ORG of I-ORG Jilin I-ORG Province I-ORG of I-ORG China I-ORG No. O 20150520064JH B-AWARD This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51701172 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M632977 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG 2018JJ3504 O Educational O Commission O of O Hunan O Province O of O China O 16C1527 O Foundation O of O Xiangtan O University O KZ08034 O and O Natural O Science O Foundation O of O Xiangtan O University O KZ03014 O This O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Fund I-ORG Project I-ORG 31100865 O the O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Project I-ORG 6172015 O and O the O Science B-ORG Project I-ORG of I-ORG Beijing I-ORG Park I-ORG Management I-ORG Center I-ORG ZX O 2016025 O The O funders O had O no O role O in O the O study O design O data O collection O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O No. O 61674025 B-AWARD and O No. O 61306035 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG under O Grant O No. O ZYGX2016J056 B-AWARD and O Open B-ORG Projects I-ORG of I-ORG Sichuan I-ORG Key I-ORG Laboratory I-ORG of I-ORG Meteorological I-ORG Information I-ORG and I-ORG Signal I-ORG Processing I-ORG under O Grant O No. O QXXCSYS201504 B-AWARD and O No. O QXXCSYS201603 B-AWARD This O work O was O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81704002 B-AWARD Shenzhen B-ORG Scientific I-ORG Research I-ORG Fund I-ORG No. O JCYJ20160428180924481 B-AWARD and O Sanming B-ORG Project I-ORG of I-ORG Medicine I-ORG in I-ORG Shenzhen I-ORG SZSM201512043 O This O study O was O supported O in O part O by O grants O from O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81503531 O the O Education B-ORG Department I-ORG of I-ORG Jilin I-ORG Province I-ORG No. O 2015536 O the O Science B-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Jilin I-ORG Province I-ORG No. O 201215078 O and O the O Health B-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG Jilin I-ORG Province I-ORG No. O 2011Z048 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O the O Discipline B-ORG Construction I-ORG Fund I-ORG Project I-ORG of I-ORG Gansu I-ORG Agricultural I-ORG University I-ORG GSAU-XKJS-2018-230 O the O Fostering B-ORG Foundation I-ORG for I-ORG the I-ORG Excellent I-ORG Ph.D I-ORG Dissertation I-ORG of I-ORG Gansu I-ORG Agricultural I-ORG University I-ORG 2017002 O and O the O Science B-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG Gansu I-ORG Province I-ORG 18ZD2NA006 O This O research O was O funded O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NCI O R01CA222596 I-AWARD NIEHS I-AWARD T32ES07266 O Department B-ORG of I-ORG Defense I-ORG grant O number O W81XWH-16-1-0203 B-AWARD American B-ORG Cancer I-ORG Society I-ORG grant O number O RSG-16-213-01-TBE B-AWARD and O Kentucky B-ORG Lung I-ORG Cancer I-ORG Research I-ORG Program I-ORG KLCRP2016 O The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O National O Institutes O of O Health O or O other O funding O agencies O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31802111 B-AWARD the O Scientific B-ORG and I-ORG Technological I-ORG Research I-ORG Projects I-ORG in I-ORG Henan I-ORG Province I-ORG Nos O 192102110068 B-AWARD 182102110302 I-AWARD 202102110235 O and O the O Key B-ORG Scientific I-ORG Research I-ORG Projects I-ORG Plan I-ORG of I-ORG Henan I-ORG Higher I-ORG Education I-ORG Institutions I-ORG No. O 17A180021 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Research O reported O in O this O publication O was O supported O by O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG of I-ORG the I-ORG National I-ORG Institutes I-ORG of I-ORG Health I-ORG under O award O number O P20GM109021 B-AWARD and O an O Institutional B-ORG Development I-ORG Award I-ORG IDeA I-ORG from I-ORG the I-ORG National I-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG of I-ORG the I-ORG National I-ORG Institutes I-ORG of I-ORG Health I-ORG under O grant O number O U54-GM104941 B-AWARD Development O of O the O Nemours O PEDSnet O data O resource O was O supported O by O Patient-Centered B-ORG Outcomes I-ORG Research I-ORG Institute I-ORG PCORI O award O number O 1306-01556 B-AWARD This O work O was O supported O by O intramural O grants O from O the O Korea B-ORG National I-ORG Institute I-ORG of I-ORG Health I-ORG 2013-NG73001-00 O Biospecimens O and O data O were O obtained O from O the O Korean B-ORG Genome I-ORG Analysis I-ORG Project I-ORG 4845-301 O the O Korean B-ORG Genome I-ORG and I-ORG Epidemiology I-ORG Study I-ORG 4851-302 O and O the O Korea B-ORG Biobank I-ORG Project I-ORG 4851-307 O KBP-2014-02 O which O are O supported O by O the O Korea O Center O for O Disease O Control O and O Prevention O Republic O of O Korea O This O study O was O supported O in O part O by O grants O from O the B-ORG Key I-ORG Research I-ORG Project I-ORG of I-ORG Jiangxi I-ORG Province I-ORG China I-ORG No. O 20171BBG70063 B-AWARD Education B-ORG Department I-ORG of I-ORG Jiangxi I-ORG Province I-ORG No. O GJJ150260 B-AWARD the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Nation I-ORG China I-ORG No. O 81760438 B-AWARD and O the B-ORG Innovation I-ORG Research I-ORG Foundation I-ORG of I-ORG Graduate I-ORG School I-ORG of I-ORG Nanchang I-ORG University I-ORG No. O CX2017204 B-AWARD This O work O was O supported O by O grants O from O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province(2013B090200057 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81371046 O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Hainan I-ORG Province I-ORG ZDYF2016111 O and O Natural B-ORG Science I-ORG Fundation I-ORG of I-ORG Hainan I-ORG Province I-ORG 2017CXTD011 O This O project O was O supported O by O the O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG grant O no. O 17401931600 B-AWARD Science B-ORG and I-ORG Technology I-ORG Development I-ORG Fund I-ORG of I-ORG Baoshan I-ORG District I-ORG grant O number O 17-E-12 B-AWARD Excellent B-ORG Young I-ORG Doctor I-ORG Training I-ORG Program I-ORG from I-ORG Baoshan I-ORG District I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission O Shanghai O grant O no. O bswsyq-2017-A02 B-AWARD Young O Doctor O Talent O Training O Program O from O Baoshan O Hospital O of O Integrated O Traditional O Chinese O Medicine O and O Western O Medicine O Shanghai O grant O no. O 2016 O These O funding O bodies O did O not O have O any O role O in O the O study O design O or O the O decision O to O submit O the O manuscript O for O publication O This O work O was O supported O by O grants O from O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFE0108500 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31600067 O 21506113 B-AWARD 31470229 B-AWARD and O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017T100064 O 2015M581074 B-AWARD This O study O is O supported O by O the O NSFC B-ORG Projects O 81501014 O HXS O 81501029 B-AWARD LYQ O and O 81371305 O YW) O and O Guangdong B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Q17056016 O HXS O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017A020211009 O DJW O This O study O was O supported O by O a O grant O NSC-100-2321-B-075A-001 O from O the O National B-ORG Science I-ORG Council O Taiwan O a O grant O from O Taichung B-ORG Veterans I-ORG General I-ORG Hospital O Taiwan O TCVGH-993804C O and O by O the O China B-ORG Medical I-ORG University I-ORG Hospital O Taiwan O DMR-C1030224007 O J-LL O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81872996 B-AWARD the O National O Science O and O Technology O Major O Project O of O China O Grant O No. O 2018ZX09201011 O the O State B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG Grant O No. O 2017YFC1702104 B-AWARD and O the O Tianjin B-ORG Municipal I-ORG Education I-ORG Commission I-ORG Research I-ORG Project I-ORG Grant O No. O 2017ZD07 B-AWARD This O work O is O funded O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC1004900 O and O 2016YFC1000600 B-AWARD Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG LY19C050002 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81602263 O and O 81471494 B-AWARD This O study O was O supported O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC1308000 O The B-ORG Capital I-ORG Health I-ORG Research I-ORG and I-ORG Development I-ORG of I-ORG Special I-ORG 2018-2-2-66 O the B-ORG National I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81600362 O Beijing B-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospitals’ I-ORG Youth I-ORG Program O QML20170602 B-AWARD and O the B-ORG Beijing I-ORG Lab I-ORG for I-ORG Cardiovascular I-ORG Precision I-ORG Medicine I-ORG Beijing I-ORG China O PXM2017_014226_000037 B-AWARD This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31771128 O the O FHS O Internal O Collaboration O Proposals O 2017 O MYRG2016-00052-FHS B-AWARD and O MYRG2018-00134-FHS B-AWARD from O University B-ORG of I-ORG Macau O and O the O Science B-ORG and I-ORG Technology I-ORG Development I-ORG Fund I-ORG FDCT I-ORG of I-ORG Macao I-ORG 016/2016/A1 O and O 0113/2018/A3 B-AWARD This O work O was O supported O by O the O Project O of O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2017BC039 O ZR2015CM009 B-AWARD Young O Talents O Training O Program O of O Shandong O Academy O of O Agricultural O Sciences O Construction B-ORG of I-ORG Subjects I-ORG and I-ORG Teams I-ORG of I-ORG Institue I-ORG of I-ORG Poultry I-ORG Science I-ORG CXGC2018E11 O Shandong O Provincial O Key O Laboratory O of O Special O Construction O Project O SDKL201810 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG 2016YFD0501603-3 O Key B-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG of I-ORG Shandong I-ORG Province I-ORG 2018GSF121012 O and O Agricultural O Science O and O Technology O Innovation O Project O of O Shandong O Academy O of O Agricultural O Sciences O CXGC2016A10 O J.Z O and O Q.C O were O supported O by O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG grant O nos O 2015003 B-AWARD B201119 O Q.C O and O S.Z O were O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O nos O 21671050 B-AWARD 41571199 O and O Q.C O was O supported O by O the B-ORG Foundation I-ORG for I-ORG academic I-ORG leaders I-ORG of I-ORG Harbin I-ORG grant O no. O 2013RFXXJ009 B-AWARD We O are O grateful O for O financial O support O from O Bulgarian B-ORG Science I-ORG Fund I-ORG project O number O KП-06-H-58/12 B-AWARD Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG MOST O Taiwan O project O number O MOST B-AWARD 110-2221-E-A49-098-MY3 I-AWARD and O the O Bilateral O grant O agreement O between O Bulgarian B-ORG Academy I-ORG of I-ORG Sciences I-ORG BAS O and O Ministry O of O Science O and O Technology O MOST O Taiwan O under O PPP O program O project O number O MOST B-AWARD 111-2927-I-A49-507 O Research O equipment O of O distributed O research O infrastructure O INFRAMAT O part O of O Bulgarian O National O roadmap O for O research O infrastructures O supported O by O Bulgarian O Ministry O of O Education O and O Science O is O also O acknowledged O This O work O was O supported O in O part O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81803801 O Hundred O Talents O Program O from O Shanghai B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG 2018BR03 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG 17ZR1430800 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018T110405 O 2017M610272 B-AWARD and O Longhua B-ORG Medical I-ORG Innovation I-ORG Team I-ORG Program I-ORG LYCX-01 O This O work O was O supported O by O grants O from O the B-ORG Project I-ORG of I-ORG Development I-ORG of I-ORG Microsatellite I-ORG Derived I-ORG from I-ORG Acipenser I-ORG dabryanus I-ORG and I-ORG its I-ORG Application I-ORG in I-ORG Paternity I-ORG Test I-ORG NO. O 2017QNJJ-012 B-AWARD recipient O YL O the B-ORG Project I-ORG of I-ORG Screening I-ORG of I-ORG Sex-linked I-ORG Markers I-ORG and I-ORG Sex I-ORG Determination I-ORG Gene I-ORG for I-ORG Acipenser I-ORG dabryanus I-ORG Based I-ORG on I-ORG Transcriptome I-ORG Sequencing I-ORG Technology I-ORG NO. O 2017QNJJ-013 B-AWARD recipient O YYC O and O the B-ORG Project I-ORG of I-ORG Provincial I-ORG 13th I-ORG Five I-ORG Years’ I-ORG Animal I-ORG Breeding I-ORG of I-ORG Sichuan I-ORG Province I-ORG NO. O 2016NYZ0047 B-AWARD recipient O JD O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O National B-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81703027 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O SBE2016740780BE2016787 B-AWARD and O the O Jiangsu B-ORG Provincial I-ORG Health I-ORG Planning I-ORG and I-ORG Research I-ORG Project I-ORG H2017019 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 62001159 O the O Scientific B-ORG Research I-ORG Project I-ORG of I-ORG Education I-ORG Department I-ORG of I-ORG Hubei I-ORG Province I-ORG 20212806 O the O Special B-ORG Fund I-ORG Projects I-ORG of I-ORG Hubei I-ORG Key I-ORG Laboratory I-ORG of I-ORG Radiation I-ORG Chemistry I-ORG and I-ORG Functional I-ORG Materials I-ORG 2022ZX05 O 2021ZX07 B-AWARD the O Research B-ORG and I-ORG Development I-ORG Fund I-ORG Project I-ORG of I-ORG Hubei I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2023-25GP02 O and O the O Research O and O Development O Fund O Project O of O Hubei O University O of O Science O and O Technology O No. O H2019004 B-AWARD The O research O was O funded O by O Tianjin B-ORG Research I-ORG Program I-ORG of I-ORG Application I-ORG Foundation I-ORG and I-ORG Advanced I-ORG Technology I-ORG 15JCQNJC12000 O The B-ORG Science I-ORG Technology I-ORG Development I-ORG Fund I-ORG of I-ORG Tianjin I-ORG Education I-ORG Commission I-ORG for I-ORG Higher I-ORG Education I-ORG 2017SK097 O The B-ORG National I-ORG Natural I-ORG Science I-ORG Fund I-ORG 71673199 O All O the O funding O body O funded O for O data O collection O experts O consultation O as O well O as O personnel O service O fees O in O the O research O This O project O was O funded O by O grants O from O the O National B-ORG Institute I-ORG of I-ORG Child I-ORG Health I-ORG and I-ORG Human I-ORG Development I-ORG R37 O HD29957 O the O National B-ORG Institute I-ORG of I-ORG Neurological I-ORG Disorders I-ORG and I-ORG Stroke I-ORG R01 O NS35102 O and O the O Williams B-ORG Syndrome I-ORG Association I-ORG WSA O 0104 O WSA B-AWARD 0111 O to O the O corresponding O author O The O second O author’s O work O on O this O project O was O partially O supported O by O a O grant O from O the O National B-ORG Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute I-ORG R01 O HL10599 O Ronald O D. O Chervin O PI O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 11802196 B-AWARD 11632013 B-AWARD 11572213 B-AWARD 31800789 B-AWARD 11702184 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG for I-ORG Young I-ORG Scientists I-ORG of I-ORG Shanxi I-ORG Province I-ORG China I-ORG Grant O No. O 201701D221014 B-AWARD and O the O School B-ORG Foundation I-ORG of I-ORG Taiyuan I-ORG University I-ORG of I-ORG Technology I-ORG No. O 1205-04020203 B-AWARD This O research O was O partially O supported O by O the O MSIT O Ministry O of O Science O ICT O under O the O ITRC O Information O Technology I-ORG Research I-ORG Center O support O program O IITP-2018-2014-0-00639 O supervised O by O the O IITP O and O NRF O National O Research I-ORG Foundation O under O basic O engineering O research O project O 2016R1D1A1B0101440 O and O the O EDISON B-ORG NRF-2011-0020576 O Programs O This O study O was O supported O by O grants O from O National B-ORG Space I-ORG Biomedical I-ORG Research I-ORG Institute I-ORG NASA O NCC I-AWARD 9-58 O National B-ORG Aeronautics I-ORG and I-ORG Space I-ORG Administration I-ORG NNX11AR02G O and O National B-ORG Institutes I-ORG of I-ORG Health I-ORG 1S10OD012240-01A1 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O financially O supported O by O the O Integration B-ORG of I-ORG Science I-ORG and I-ORG Education I-ORG Programme I-ORG Foundation I-ORG for I-ORG the I-ORG Talents I-ORG by I-ORG Qilu I-ORG University I-ORG of I-ORG Technology I-ORG 2018-81110268 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2019BC022 O and O the B-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Biobased I-ORG Material I-ORG I-ORG Green I-ORG Papermaking I-ORG in I-ORG Qilu I-ORG University I-ORG of I-ORG Technology O China O Project O No. B-AWARD KF201823 O This O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Youth I-ORG Fund I-ORG 31901269 O This O project O was O supported O by O a O grant O from O Prof O Zhang O Ping’s O Special B-ORG Scientific I-ORG Research I-ORG Fund I-ORG of I-ORG Public I-ORG Welfare I-ORG Profession I-ORG from I-ORG National I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG China I-ORG No. O 201502010 B-AWARD Pro O Chen O Jianghua’s O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG No. O 2018YFC1214003 B-AWARD and O Prof O Lin O Weiqiang’s O National B-ORG Natural I-ORG Science I-ORG foundation I-ORG of I-ORG China I-ORG No. O 81670651 B-AWARD These O funds O were O used O to O maintain O the O ZJRDS O database O operation O update O the O statistical O software O and O pay O patients O follow-up O fee O Markus O D O Schirmer O H2020 B-ORG European I-ORG Research I-ORG Council I-ORG http://dx.doi.org/10.13039/100010663 O Award O ID: O 753896 B-AWARD Ai O Wern O Chung O American B-ORG Heart I-ORG Association I-ORG US O Award O ID: O 19POST34380005 B-AWARD Natalia O S. O Rost O National B-ORG Institute I-ORG of I-ORG Neurological I-ORG Disorders I-ORG and I-ORG Stroke I-ORG http://dx.doi.org/10.13039/100000065 O Award O ID: O R01NS086905 B-AWARD Natalia O S. O Rost O National B-ORG Institutes I-ORG of I-ORG Health I-ORG http://dx.doi.org/10.13039/100000002 O Award O ID: O 5R01NS082285 B-AWARD This O work O was O supported O by O Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG for I-ORG Chinese I-ORG Academy I-ORG of I-ORG Tropical I-ORG Agricultural I-ORG Sciences I-ORG No.1630092020002),The O National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31501371),The O Earmarked I-ORG Fund I-ORG For I-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-31-02,03 O The O funders O had O no O role O in O the O experimental O design O data O collection O and O analysis O or O writing O the O manuscript O This O work O was O supported O by O the O Welcome O Trust O Principal O Fellowship O 101896 O European B-ORG Research I-ORG Council I-ORG Advanced O Grant O 323113 O NETSIGNAL O Russian B-ORG Science I-ORG Foundation I-ORG Grant O 15-14-30000 O computing O cluster O setup O FP7 O ITN O 606950 O EXTRABRAIN O and O European B-ORG Research I-ORG Council I-ORG Proof-of-Concept I-ORG Grant O 767372 O NEUROCLOUD O We O appreciate O the O support O from O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2020YFC0845800 O 2020YFC0842500 B-AWARD the O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG 2020YJFK0107 O the O Chinese B-ORG Academy I-ORG of I-ORG Engineering I-ORG 2020-ZD-15 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 52041006 O This O work O was O supported O by O the O following O funding O sources O the O Financial B-ORG Special I-ORG Fund I-ORG 2015CZZX001 O the O Tibet B-ORG Department I-ORG of I-ORG Major I-ORG Projects I-ORG Z2016B01N01 O and O the O National B-ORG Key I-ORG Laboratory I-ORG of I-ORG Special I-ORG Research I-ORG Z2016D03G01 O This O research O was O supported O by O Major B-ORG Projects I-ORG on I-ORG College I-ORG Leading I-ORG Talent I-ORG Team I-ORG Introduced I-ORG of I-ORG Anhui I-ORG Grant O number O 0303011224 B-AWARD the O Key B-ORG Scientific I-ORG Research I-ORG Fund I-ORG of I-ORG Anhui I-ORG Provincial I-ORG Education I-ORG Department I-ORG Grant O number O KJ2017A189 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O number O 81973064 B-AWARD This O work O was O supported O by O a O Project O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31372330 O the O Program B-ORG for I-ORG Innovation I-ORG Research I-ORG Team I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG IRT16R23 O NSFC-Henan B-ORG joint I-ORG grant I-ORG U1704233 O and O the O Key B-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Project I-ORG of I-ORG Henan I-ORG Province I-ORG 172102110045 O The O funding O agencies O had O not O involved O in O the O experimental O design O analysis O and O interpretation O of O the O data O or O writing O of O the O manuscript O This O research O was O funded O by: O i) O CIEPQPF-UC O supported O by O Fundação B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG a I-ORG Tecnologia I-ORG FCT O through O projects O UIDB/00102/2020 B-AWARD and O UIDP/QUI/00102/2020 B-AWARD co-founded O by O COMPETE2020-EU O ii) O Fundação B-ORG Luso-Americana I-ORG para I-ORG o I-ORG Desenvolvimento I-ORG Portugal)/National I-ORG Science I-ORG Foundation I-ORG USA O through O Project O Ref O A1/Proj B-AWARD 75/13 O FLAD/NSF B-AWARD 2013 O iii O CQC-IMS B-ORG supported O by O FCT O through O projects O UIDB/00313/2020 B-AWARD and O UIDP/QUI/00313/2020 B-AWARD co-founded O by O COMPETE2020-EU O iv) O Laserlab-Europe O no. O 284464 O EC’s O 7th O Framework O Programme O A.M.A.D O acknowledges O FCT O for O a O contract O under O the O program O Investigador B-ORG FCT I-ORG IF/00455/2013 B-AWARD and O under O the O program O Stimulus B-ORG of I-ORG Scientific I-ORG Employment—Individual I-ORG Support O CEECIND/01248/2017 B-AWARD This O research O was O funded O by O the O Guizhou B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG Grant O number O No. O 1061 B-AWARD the O “Hundred” B-ORG Level I-ORG Innovative I-ORG Talent I-ORG Foundation I-ORG of I-ORG Guizhou I-ORG Province I-ORG Grant O number O No. O GCC B-AWARD 2022]023-1 O the O Research B-ORG on I-ORG targeted I-ORG knockout I-ORG of I-ORG fruit I-ORG cracking-related I-ORG genes I-ORG based I-ORG on I-ORG CRISPR/Cas9 I-ORG system” O Grant O number O 2019 B-AWARD No.1061 O and O the O Talent B-ORG 532 I-ORG Base I-ORG Project I-ORG of I-ORG Organization I-ORG Department I-ORG in I-ORG Guizhou I-ORG Province I-ORG China I-ORG Grant O number O QRLF B-AWARD 2013 I-AWARD 533 I-AWARD no. I-AWARD 15) O Grant O number O QRLF B-AWARD 2016 I-AWARD no. I-AWARD 23) O Grant O number O QRLF B-AWARD 2020 I-AWARD no. I-AWARD 2). O This O work O was O supported O by O the O Cooperative B-ORG Research I-ORG Program I-ORG for I-ORG Agriculture I-ORG Science I-ORG I-ORG Technology I-ORG Development I-ORG grant O no. O PJ0118512016 B-AWARD the O BioGreen B-ORG 21 I-ORG Program I-ORG grant O no. O PJ01119601 B-AWARD of O the O Rural O Development O Administration O and O the O Bio-industry B-ORG Technology I-ORG Development I-ORG Program I-ORG grant O no. O IPET312060-5 B-AWARD of O the O Ministry O of O Agriculture O Food O and O Rural O Affairs O Republic O of O Korea O to O DIJ O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O funding O from O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG CAS O “Light O of O West O China” O program O and O National O Natural O Science O Foundation O of O China O NSFC O Grant O 31900332 O to O L.L O and O funding O from O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21761142002 O Chinese O Academy O of O Sciences O XDB31000000 O SAJC201606 I-AWARD and I-AWARD KGFZD-135-17-011 O Biological O Resources O Programme O Chinese O Academy O of O Sciences O KFJ-BRP-008 O and O Yunnan B-ORG Province I-ORG 2015HA023 O and I-AWARD 2019ZF003 O to O R.L O This O research O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG grant O numbers O F2019202294 B-AWARD F2019202337 B-AWARD and O F2019202252 B-AWARD the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Luminescence I-ORG and I-ORG Applications I-ORG grant O number O SKLA-2019-07 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Tianjin I-ORG City I-ORG grant O number O 15JCYBJC17000 B-AWARD This O work O was O supported O by O a O General O Research O Fund O grant O from O the O University B-ORG Grant I-ORG Committee O Hong O Kong O grant O number O HKU B-AWARD 741511H O and O by O Research B-ORG Foundation I-ORG Flanders I-ORG project O number O B/13018/01 B-AWARD Cerin O was O supported O by O an O Australian B-ORG Research I-ORG Council I-ORG Future O Fellowship O grant O number O FT14010085 B-AWARD Van O Dyck O and O Van O Cauwenberg O were O supported O by O Research O Foundation O Flanders O grant O numbers O FWO12/PDO/158 B-AWARD and O FWO12I1117 B-AWARD The O funding O bodies O had O no O roles O in O the O design O of O the O studies O interpretation O of O data O decision O to O publish O or O writing O of O the O manuscript O This O study O was O supported O by O the B-ORG Special I-ORG Projects I-ORG of I-ORG Cooperation I-ORG between I-ORG Jilin I-ORG University I-ORG and I-ORG Jilin I-ORG Province I-ORG in I-ORG China I-ORG SXGJSF2017-1 O the B-ORG “13th I-ORG Five-year” I-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG from I-ORG Education I-ORG Department I-ORG in I-ORG Jilin I-ORG Province I-ORG JJKH20190108KJ O Research B-ORG Grant I-ORG Council I-ORG HKSAR I-ORG Project O code O RGC B-AWARD GRF I-AWARD 17152116 O Commissioner B-ORG for I-ORG Innovation I-ORG Technology I-ORG HKSAR I-ORG Project O code O ITS/091/16FX B-AWARD and O Health B-ORG and I-ORG Medical I-ORG Research I-ORG Fund I-ORG Project O code O 15162961 B-AWARD This O study O was O partly O supported O by O MEXT B-ORG KAKENHI I-ORG Grant O Number O JP21119003 B-AWARD JSPS B-ORG KAKENHI I-ORG Grant O Number O JP16H06395 B-AWARD 16H06398 I-AWARD and I-AWARD 16K21720 O The O Japanese O Study O on O Stratification O Health O Income O and O Neighborhood O J-SHINE O was O supported O by O a O Grant-in-Aid B-ORG for I-ORG Scientific I-ORG Research I-ORG on I-ORG Innovative I-ORG Areas I-ORG No. O 1119002 B-AWARD from O the O Ministry O of O Education O Culture O Sports O Science O and O Technology O Japan O The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O the O writing O of O the O report O or O the O decision O to O submit O the O paper O for O publication O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 31271595 B-AWARD to O TL) O and O the O Key B-ORG Project I-ORG of I-ORG Chinese I-ORG National I-ORG Programs I-ORG for I-ORG Fundamental I-ORG Research I-ORG and I-ORG Development I-ORG 973 O Programs O 2013CB9669002 B-AWARD to O TL O This O work O was O also O supported O by O the O Science B-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG 2015A020212032 O to O TL) O and O Guangdong O Provincial O Hospital O of O Chinese O Medicine O YK2013B2N08 O to O TL O The O authors O acknowledge O financial O support O from O Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Grant O JCYJ20170818144148488 O JCYJ20170818143831242 B-AWARD and O JCYJ20170818093417096 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Project O Nos O 51773118 B-AWARD Hong O Kong O Research O Grants O Council O PolyU O 123384/16P B-AWARD and O the O Hong B-ORG Kong I-ORG Polytechnic I-ORG University I-ORG 1-ZE1C O and O 847S B-AWARD Our O research O leading O to O these O results O has O received O funding O from O the O European O Union’s O Horizon O 2020 O research O and O innovation O programme O under O the O Marie B-ORG Sklodowvska-Curie I-ORG grant O agreement O 871284 B-AWARD project O SSHARE O the O European B-ORG Regional I-ORG Development I-ORG Fund I-ORG ERDF O through O the O Operational O Programme O for O Competitiveness O and O Internationalization O COMPETE O 2020 O under O project O POCI-01-0145-FEDER-029494 B-AWARD and O by O national B-ORG funds I-ORG through O the O FCT—Portuguese O Foundation O for O Science O and O Technology O under O projects O PTDC/EEI-EEE/29494/2017 B-AWARD UIDB/04131/2020 B-AWARD and O UIDP/04131/2020 B-AWARD This O study O was O supported O financially O by O the O One B-ORG Hundred I-ORG Talents I-ORG Program I-ORG in I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Y3H1051001 O Outstanding B-ORG Youth I-ORG Fund I-ORG from I-ORG Heilongjiang I-ORG Province I-ORG JC201401 O basic O research O fund O for O national O universities O from O the O Ministry B-ORG of I-ORG Education I-ORG of I-ORG China I-ORG 2572014EA01 O 2572017DG04 B-AWARD Key O project O from O Chinese O Academy O of O Sciences O KFZD-SW-302 O NSFC B-ORG project I-ORG 31670699 O 41730641 B-AWARD There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O work O was O funded O by O the O Research B-ORG Grants I-ORG Council I-ORG General I-ORG Research I-ORG Fund I-ORG Project O No. O 17105322 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG General I-ORG Program I-ORG Project O No. O 81872340 B-AWARD and O 82072626 B-AWARD and O the O University B-ORG Research I-ORG Committee I-ORG Seed I-ORG Fund I-ORG for I-ORG Basic I-ORG Research I-ORG Project O No. O 202111159009 B-AWARD of O the O University O of O Hong O Kong O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 62072143 B-AWARD and I-AWARD 62032007 O graduate O innovation O program O of O Harbin O Medical O University O YJSCX2020-32HYD O and O research O and O innovation O fund O of O the O First O Affiliated O Hospital O of O Harbin O Medical O University O NO.2021B17 O and O the O National O Natural O Science O Foundation O of O China O grant O numbers O 82072000 B-AWARD and I-AWARD 81671769 I-AWARD to O XL O the O Central B-ORG University I-ORG Basic I-ORG Research I-ORG Fund I-ORG of I-ORG China I-ORG grant O number O HIT B-AWARD NSRIF I-AWARD 2020042 I-AWARD to O XL O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Province O China O grant O number O LH2019H001 B-AWARD to O XL O This O study O was O funded O by O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG No. O 2011ZX09307-001-07 O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81571219 O and O the O Beijing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG No. O Z151100003915126 O Precisionmdx O Inc O provided O support O in O the O form O of O salaries O for O author O Peng O Yu, O but O did O not O have O any O additional O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O specific O roles O of O this O author O is O articulated O in O the O ‘author O contributions’ O section O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31960023 B-AWARD 31600083 B-AWARD the O Reserve B-ORG Talents I-ORG Project I-ORG for I-ORG Young I-ORG and I-ORG Middle-Aged I-ORG Academic I-ORG and I-ORG Technical I-ORG Leaders I-ORG of I-ORG Yunnan I-ORG Province I-ORG Grant O No. O 2018HB059 B-AWARD and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2017YFB0308401 B-AWARD This O work O was O supported O by O the O Second B-ORG Tibetan I-ORG Plateau I-ORG Scientific I-ORG Expedition I-ORG and I-ORG Research I-ORG project I-ORG 2019QZKK0706 O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDB26000000 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41925008 O and O 42288201 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 22004038 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG 2021A1515010102 O the O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG 2021A1515111174 O the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Guangzhou I-ORG 202201010471 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2022M722112 O and O a O start-up O fund O from O the O Institute B-ORG of I-ORG Basic I-ORG Medicine I-ORG and I-ORG Cancer I-ORG IBMC I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG 2022QD13 O This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0500300 O and O 2017YFC1600100 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG 2017CFB445 O the O National B-ORG Program I-ORG for I-ORG Risk I-ORG Assessment I-ORG of I-ORG Quality I-ORG and I-ORG Safety I-ORG of I-ORG Livestock I-ORG and I-ORG Poultry I-ORG Products I-ORG GJFP2019007 O and O National B-ORG Program I-ORG for I-ORG Risk I-ORG Assessment I-ORG of I-ORG Quality I-ORG and I-ORG Safety I-ORG of I-ORG Milk I-ORG GJFP201800804 O This O work O was O supported O by O the B-ORG National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O NSFC81770944 O 81770925 B-AWARD 81790641 B-AWARD the B-ORG Non-profit I-ORG Central I-ORG Research I-ORG Institute I-ORG Fund I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG 2018PT32019 B-AWARD This O research O was O funded O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 42001231 B-AWARD 42001187 B-AWARD and O 41701629 B-AWARD MOE B-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG Project I-ORG of I-ORG Humanities I-ORG and I-ORG Social I-ORG Sciences I-ORG grant O number O 19YJCZH224 B-AWARD and O Key B-ORG Laboratory I-ORG of I-ORG Geospatial I-ORG Technology I-ORG for I-ORG Middle I-ORG and I-ORG Lower I-ORG Yellow I-ORG River I-ORG Regions I-ORG Henan I-ORG University I-ORG Ministry I-ORG of I-ORG Education I-ORG No. O GTYR202205 B-AWARD This O research O was O supported O by O the B-ORG Foundation I-ORG of I-ORG National I-ORG Key I-ORG Program I-ORG of I-ORG Research I-ORG and I-ORG Development I-ORG of I-ORG China I-ORG Grant O NO: O 2016YFC0900803 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O NO: O 81573243 B-AWARD 21806146 O Henan B-ORG Provincial I-ORG Science I-ORG Fund I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG Grant O NO: O 164100510021 B-AWARD Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Talents I-ORG Support I-ORG Plan I-ORG of I-ORG Henan I-ORG Province I-ORG Colleges I-ORG and I-ORG Universities I-ORG Grant O NO: O 14HASTIT035 B-AWARD High-level B-ORG Personnel I-ORG Special I-ORG Support I-ORG Project I-ORG of I-ORG Zhengzhou I-ORG University I-ORG Grant O NO: O ZDGD13001 B-AWARD The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 71603187 O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG LQ16G030011 O and O the B-ORG Key I-ORG Social I-ORG Science I-ORG Project I-ORG for I-ORG University I-ORG Teachers I-ORG of I-ORG Zhejiang I-ORG China I-ORG 2014QN005 O The O funders O played O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the O Wellcome B-ORG Trust I-ORG 208806 O a O Sir O Henry O Dale O Fellowship O awarded O to O Gibran O Hemani O and O the O Integrative O Epidemiology O Unit O The O Integrative O Epidemiology O Unit O is O supported O by O the O Medical B-ORG Research I-ORG Council I-ORG and O the O University O of O Bristol O MC_UU_00011/1 O MC_UU_00011/4 B-AWARD and O MC_UU_00011/6 B-AWARD Richard O Martin O is O supported O by O a O Cancer B-ORG Research I-ORG UK I-ORG programme O grant O the O Integrative O Cancer O Epidemiology O Programme O C18281/A19169 O This O research O was O funded O by O “National O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 31320103905” B-AWARD “Programs O for I-ORG Changjiang I-ORG Scholars I-ORG and I-ORG Innovative I-ORG Research I-ORG in I-ORG Universities O grant O number O IRT15R62” B-AWARD and O “Chinese O Universities I-ORG Scientific I-ORG Fund O grant O number O 2018TC026” B-AWARD This O research O was O funded O by O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Fujian I-ORG Province I-ORG no. O 2018N5002 B-AWARD Forestry B-ORG Science I-ORG Research I-ORG Project I-ORG of I-ORG Fujian I-ORG Forestry I-ORG Department I-ORG no. O Minlinke O 2017 B-AWARD 03 O Forest B-ORG Science I-ORG Peak I-ORG Project I-ORG of I-ORG College I-ORG of I-ORG Forestry I-ORG Fujian I-ORG Agriculture I-ORG and I-ORG Forestry I-ORG University I-ORG no. O 71201800720 B-AWARD 71201800753 B-AWARD and O 71201800779 B-AWARD This O research O was O funded O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Chongqing O China O grant O number O CSTB2022NSCQ-MSX0778 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 32272674 B-AWARD Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG for I-ORG Chinese I-ORG Academy I-ORG of I-ORG Tropical I-ORG Agricultural I-ORG Sciences O grant O number O 1630062020003 B-AWARD Scientific B-ORG and I-ORG Technological I-ORG Research I-ORG Program I-ORG of I-ORG Chongqing I-ORG Municipal I-ORG Education I-ORG Commission O grant O number O KJQN202101445 B-AWARD This O work O was O supported O by O the O USDA B-ORG National I-ORG Institute I-ORG of I-ORG Food I-ORG and I-ORG Agriculture I-ORG competitive I-ORG grant I-ORG 2017-67007-25939 O to O Guorong O Zhang O and O Hatch B-ORG grant I-ORG 1001453 O to O Guorong O Zhang O and O Ohio B-ORG University I-ORG Start-Up I-ORG grant I-ORG SU1007172 O to O Zhihua O Hua O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG key I-ORG research I-ORG and I-ORG development I-ORG program I-ORG 2022YFA1304400 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32172371 O and O the O earmarked O fund O of O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-13 O This O work O has O been O partially O funded O by O the B-ORG project I-ORG “SisTEmi I-ORG multifunzionali I-ORG nanofibrosi I-ORG per I-ORG controllare I-ORG e I-ORG riduRRE I-ORG gli I-ORG impatti I-ORG ambientali I-ORG nei I-ORG sistemi I-ORG agricoli I-ORG TERRE)” I-ORG under I-ORG the I-ORG “Progetti I-ORG di I-ORG ricerca I-ORG CNR I-ORG 2020” I-ORG programme O The O financial O support O provided O by O the B-ORG Italian I-ORG MIUR O PRIN B-AWARD 2017 I-AWARD 2017YJMPZN I-AWARD is O also O acknowledged O The O project O was O also O partially O funded O under O the O National O Recovery O and O Resilience O Plan O NRRP O Mission O 4, O Component O 2 O Investment O 1.3—Call O for O tender O No. O 341 O of O 15 O March O 2022 O of O Italian O Ministry O of O University O and O Research O funded O by O the B-ORG European I-ORG Union—NextGenerationEU I-ORG Award O Number O Project O code O PE00000003 B-AWARD Concession O Decree O No. O 1550 O of—11 O October O 2022 O adopted O by O the O Italian O Ministry O of O University O and O Research O Project O title O “ON O Foods—Research O and O innovation O network O on O food O and O nutrition O Sustainability O Safety O and O Security—Working O ON O Foods” O This O study O was O carried O out O within O the O Agritech O National O Research O Center O and O received O funding O from O the B-ORG European I-ORG Union I-ORG Next-Generation I-ORG EU I-ORG PIANO O NAZIONALE O DI O RIPRESA O E O RESILIENZA O PNRR O MISSIONE O 4 O COMPONENTE O 2, O INVESTIMENTO O 1.4 O D.D O 1032 O 17/06/2022 O CN00000022 B-AWARD This O manuscript O reflects O only O the O authors’ O views O and O opinions O not O those O of O the O European O Union O or O the O European O Commission O which O cannot O be O considered O responsible O for O them O This O research O was O funded O by O the O Australian B-ORG Research I-ORG Council I-ORG DECRA O Fellowship O DE160101142 B-AWARD to O E.A.B.U O the O Research O Council O of O Norway O FRIPRO-YRT O Fellowship O no. O 287462 O to O E.A.B.U O and O the O University O of O Queensland O International O UQ O Research O Training O PhD O Scholarship O to O V.S O R.A.J O was O funded O by O Natural B-ORG Environment I-ORG Research I-ORG Council I-ORG grant O NE/I001530/1 B-AWARD and O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG grant O BB/K003488/1 B-AWARD This O work O was O funded O by O Bethune B-ORG project I-ORG of I-ORG Jilin I-ORG University O Grant O Number O 2018B10 B-AWARD by O Education B-ORG Department I-ORG of I-ORG Jilin I-ORG Province O Grant O Number O JJKH20180193KJ B-AWARD and O by O China B-ORG Scholarship I-ORG Council O Grant O Number O 201906210064 B-AWARD This O work O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O grant O 62261009 B-AWARD Ministry B-ORG of I-ORG Education I-ORG Key I-ORG Laboratory I-ORG of I-ORG Cognitive I-ORG Radio I-ORG and I-ORG Information I-ORG Processing I-ORG CRKL200106 O and O Innovation B-ORG Project I-ORG of I-ORG Guangxi I-ORG Graduate I-ORG Education I-ORG YCBZ2022106 O Funding O for O this O study O came O from O theSwedish O Research I-ORG Council(Vetenskapsrådet O Grant O No. O 2019-00977 B-AWARD the10.13039/501100006636Swedish O Research I-ORG Council I-ORG for I-ORG Health I-ORG Working I-ORG Life I-ORG and I-ORG Welfare(Forte O Grant O No. O 2018-00123 B-AWARD and O the10.13039/501100003793Swedish O Heart-Lung I-ORG Foundation(Hjärt-Lungfonden O Grant O No. O 20190247 B-AWARD Maria O Bruzelius O is O supported O by O funds O from10.13039/501100004348Stockholm O county I-ORG council O Siddhartha O Kar O is O supported O by O a O Cancer O Research O UK O programme O grant O the O Integrative O Cancer O Epidemiology O Programme O C18281/A19169 O Amy O M. O Mason O is O supported O by O EC-Innovative O Medicines O Initiative O BigData@Heart O Stephen O Burgess O is O supported O by O a O Sir O Henry O Dale O Fellowship O jointly O funded O by O theWellcome O Trust I-ORG and I-ORG the I-ORG Royal I-ORG Society(Grant O No. O 204623/Z/16/Z B-AWARD The O funders O had O no O role O in O study O design O data O collection O interpretation O or O the O decision O to O submit O the O work O for O publication O SCL O had O full O access O to O all O the O data O in O the O study O and O had O final O responsibility O for O the O decision O to O submit O for O publication O This O research O was O funded O by O the O Consejo B-ORG Nacional I-ORG de I-ORG Ciencia I-ORG y I-ORG Tecnología I-ORG Project O no. O CF-2019/87163 B-AWARD DGAPA-UNAM B-ORG Grant O PAPIIT B-AWARD IN208320 O National B-ORG Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases O USA O Grant O R01AI077653 B-AWARD This O research O is O supported O by O the O Key B-ORG Laboratory I-ORG Fund I-ORG of I-ORG Chinese I-ORG Academy I-ORG Of I-ORG Sciences I-ORG No. O CXJJ-17S040 B-AWARD and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.11803074 O The O Key O Laboratory O Fund O of O Chinese O Academy O Of O Sciences O No. O CXJJ-17S040 O is O contributed O for O design O atomic O layer O deposition O process O and O materials O characterization O National O Natural O Science O Foundation O of O China O No.11803074 O and O Shaanxi B-ORG Natural I-ORG Science I-ORG Basic I-ORG Research I-ORG Project I-ORG No. O 2018JM6059 B-AWARD are O contributed O for O analysis O and O interpretation O of O data O Research O in O the O authors’ O laboratory O is O supported O by O the O Medical B-ORG Research I-ORG Council I-ORG MR/P000673/1 O the O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG BB/I001794/1 O Bloodwise B-ORG 12037 O the O European O Union’s O Horizon B-ORG 2020 I-ORG GA6586250 O and O Cancer B-ORG Research I-ORG UK I-ORG C5759/A20971 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 81971755 B-AWARD Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Team I-ORG of I-ORG China I-ORG 2019JDTD0008 O Young B-ORG Elite I-ORG Scientist I-ORG Sponsorship I-ORG Program I-ORG by I-ORG CAST I-ORG 2019QNRC001 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG “111” I-ORG Project I-ORG of I-ORG China I-ORG B16033 O Key B-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG Heibei I-ORG Province I-ORG 182777172 O Provincial B-ORG Key I-ORG Technology I-ORG Support I-ORG Program I-ORG of I-ORG Sichuan I-ORG grant O no. O 2015SZ0027 B-AWARD and O Graduate B-ORG Student’s I-ORG Research I-ORG and I-ORG Innovation I-ORG Fund I-ORG of I-ORG Sichuan I-ORG University I-ORG Grant O No. O 2018YJSY067 B-AWARD This O work O was O supported O by O the O Projects O of O The B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O number O 2016YFD0501204 B-AWARD Sichuan B-ORG provincial I-ORG project I-ORG on I-ORG S&T I-ORG application I-ORG and I-ORG demonstration I-ORG grant O number O 2016CC0070 B-AWARD and O the B-ORG project I-ORG on I-ORG commercialization I-ORG of I-ORG research I-ORG findings I-ORG under I-ORG funding I-ORG of I-ORG government I-ORG of I-ORG Sichuan I-ORG province I-ORG grant O number O 16ZHSF0385 B-AWARD This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0900500 O 2016YFC0900501 B-AWARD 2016YFC0900504 B-AWARD 2017YFC0907500 B-AWARD and O 2017YFC0907504 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81390540 O 81390541 B-AWARD and O 81202266 B-AWARD The O CKB O baseline O survey O and O the O first O re-survey O were O supported O by O a O grant O from O the O Kadoorie O Charitable O Foundation O in O Hong O Kong O The O long-term O follow-up O is O supported O by O grants O from O the O UK B-ORG Wellcome I-ORG Trust I-ORG 202922/Z/16/Z O 088158/Z/09/Z B-AWARD 104085/Z/14/Z B-AWARD and O Chinese B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2011BAI09B01 O The O funders O had O no O role O in O the O study O design O data O collection O data O analysis O and O interpretation O writing O of O the O report O or O the O decision O to O submit O the O article O for O publication O CW O was O funded O by O the O UK O Medical B-ORG Research I-ORG Council I-ORG MRC O grant O number O MR/R024944/1 B-AWARD CW O and O OE O acknowledge O the O UK O Engineering B-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG EPSRC O for O funding O through O grant O reference O EP/K037145/1 B-AWARD AH O was O funded O by O a O UK O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG NIHR O Clinician O Scientist O CS012-13 O This O report O presents O independent O research O funded O by O the O NIHR O This O research O was O also O supported O by O the O NIHR O Manchester O Biomedical O Research O Centre O The O views O expressed O are O those O of O the O authors O and O not O necessarily O those O of O the O UK O National O Health O Service O the O NIHR O or O the O UK O Department O of O Health O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Peacock B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG Shenzhen I-ORG KQJSCX20170328153821275 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31601230 O Jiangsu B-ORG Province I-ORG College I-ORG Students I-ORG Innovation I-ORG Training I-ORG Program I-ORG in I-ORG 2017 I-ORG X20170820 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31702225 B-AWARD the B-ORG International I-ORG Science I-ORG and I-ORG Technology I-ORG Cooperation I-ORG Project I-ORG of I-ORG Gansu I-ORG Provincial I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG Grant O No. O 17JR7WA031 B-AWARD and O the B-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG ASTIP O Grant O No. O CAAS-ASTIP-2016-LVRI-03 B-AWARD This O research O was O funded O by O Guangxi B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG AB20159029 O Scientific B-ORG and I-ORG Technology I-ORG Development I-ORG Program I-ORG of I-ORG Guangxi I-ORG AD18126013 O the O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Team I-ORG Project I-ORG of I-ORG Guangxi I-ORG Botanical I-ORG Garden I-ORG of I-ORG Medicinal I-ORG Plants I-ORG 2019001 O and O the O Central B-ORG Government I-ORG Guides I-ORG Local I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Fund I-ORG Projects I-ORG ZY21195044 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG P.R I-ORG China I-ORG A O coupling O effects O study O of O spatial O and O temporal O process O between O impervious O surface O area O pattern O and O soil O erosion O of O Dianchi O Lake O Basin O during O fast O urbanization O Grant O no. O 41561086 B-AWARD Future O land O use/cover O simulation O and O its O response O mechanism O to O water O quality O by O coupling O human O activities O and O climate O change O effects O in O Fuxian O Lake O watershed O Grant O no. O 41861051 B-AWARD Research B-ORG on I-ORG cloud I-ORG resources I-ORG auto I-ORG scaling I-ORG and I-ORG load I-ORG balancing I-ORG by O considering O the O complexity O of O spatiotemporal O computing O Grant O no. O 41661086 B-AWARD and O the O National O Geographical O state O monitoring O demonstrative O project O —“Dynamic O monitoring O for O ecological O environment O in O Fuxian O lake O watershed” O from O the O National B-ORG Administration I-ORG of I-ORG Surveying I-ORG Mapping I-ORG and I-ORG Geoinformation I-ORG file O no. O 201435 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 1750205 B-AWARD 11674178 I-AWARD 11747101 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Tianjin I-ORG City I-ORG 17JCZDJC37900 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Henan I-ORG Province I-ORG Nos O 182102210484 B-AWARD 18A416003 O This O work O was O partly O supported O by O CAS O Key O Laboratory O of O Bio-inspired O Materials O and O Interfacial O Science O Technical O Institute O of O Physics O and O Chemistry O Chinese O Academy O of O Sciences O This O work O was O supported O by O Beijing B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG Z171100001517008 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31672573 O Beijing B-ORG New-star I-ORG Plan I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Z161100004916115 O and O by O grants O from O the O Chang O Jiang O Scholars O Program O Funding O Statement O This O work O was O supported O by O funding O from O the O Health B-ORG Research I-ORG Board I-ORG Ireland O HRA-POR-2015-1099 O and O ILP-POR-2017-024 B-AWARD Holder O D O O’Toole O the O European B-ORG Research I-ORG Council O Brussels O Belgium O under O the O Framework O 7 O Programme O ERC-2007-StG O 207777 O Holder O J O Laffey O Science B-ORG Foundation I-ORG Ireland I-ORG 16/FRL/3845 O Holder O J. O Laffey O and O from O Orbsen O Therapeutics O Ltd O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundations I-ORG of I-ORG China I-ORG Grant O No. O 81973464/H3203 B-AWARD Grant O No. O 82104379/H3203 B-AWARD Grant O No. O 82104126/H3410 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2020M680989 O Liaoning B-ORG Provincial I-ORG Doctoral I-ORG Research I-ORG Start-up I-ORG Fund I-ORG Project I-ORG for O Qian O Zhang O 2020-BS-126 O Liaoning B-ORG Distinguished I-ORG Professor I-ORG Project I-ORG for O Qing O Li O 2017 O Liaoning B-ORG BaiQianWan I-ORG Talents I-ORG Program I-ORG in O 2019 O for O Qing O Li O A-37 O Shenyang B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG for I-ORG Young I-ORG and I-ORG Middle-aged I-ORG Talents I-ORG RC190505 O Basic B-ORG Scientific I-ORG Research I-ORG project I-ORG of I-ORG Higher I-ORG education I-ORG Department I-ORG of I-ORG Liaoning I-ORG Province I-ORG LJKQZ2021033 O This O research O was O supported O by O the O National B-ORG High-Tech I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG under O Grant O 2013AA102305 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grants O 61573258 B-AWARD and O the O US B-ORG National I-ORG Science I-ORG Foundation’s I-ORG BEACON I-ORG Center I-ORG for I-ORG the I-ORG Study I-ORG of I-ORG Evolution I-ORG in I-ORG Action O under O cooperative O agreement O DBI-0939454 B-AWARD There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG ASTIP-IAS13 O National B-ORG Key I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2006BAD04A10 O and O Hebei B-ORG Province I-ORG Youth I-ORG Talent I-ORG Project I-ORG BJ2014048 O of O China O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0100903 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31771748 O 31700219 B-AWARD and O the O Shandong B-ORG Modern I-ORG Agricultural I-ORG Technology I-ORG I-ORG Industry I-ORG system I-ORG SDAIT-17-06 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81702169 O Nursery B-ORG Foundation I-ORG of I-ORG People’s I-ORG Liberation I-ORG Army I-ORG General I-ORG Hospital I-ORG 17KMM12 O and O Clinical B-ORG Support I-ORG Foundation I-ORG of I-ORG People’s I-ORG Liberation I-ORG Army I-ORG General I-ORG Hospital I-ORG 2017FC-TSYS-2043 O and O 2017FC-TSYS-3015 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81573538 B-AWARD 81603243 B-AWARD 81503193 B-AWARD and O 81403042 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFC1700705 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG of I-ORG China I-ORG No. O 2017J01804 B-AWARD This O work O was O supported O by O Wellcome B-ORG Trust I-ORG 095029 O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG BB/L009137/1 O BB/N015762/1 B-AWARD and O Medical B-ORG Research I-ORG Council I-ORG MR/L011212/1 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC-31501883 O to O L.L O NSFC-31472036 B-AWARD to O H.-Z.Z O the O Youth B-AWARD Top-notch I-AWARD Talent I-AWARD Support I-AWARD Program I-AWARD of I-AWARD Hebei I-AWARD Province I-AWARD to O L.L O BJ2018057 O the O Biodiversity B-ORG Survey I-ORG and I-ORG Assessment I-ORG Project I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Ecology I-ORG and I-ORG Environment I-ORG China I-ORG to O H.-Z.Z O 2019HJ2096001006 O a O grant O from O the O Key B-ORG Laboratory I-ORG of I-ORG the I-ORG Zoological I-ORG Systematics I-ORG and I-ORG Evolution I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG to O H.-Z.Z O Y229YX5105 O and O a O grant O from O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG to O C-Y.C O XDB26000000 O This O research O was O funded O by O 1. O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31802058 O 2. O Beijing O Innovation O Consortium O of O Agriculture O System O BAIC04 O 3. O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2019-YWF-YB-12 O and O 4. O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG ASTIPIAS04 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O No. O 31960048 O the O Hundred-Talent B-ORG Program I-ORG of I-ORG Kunming I-ORG Medical I-ORG University I-ORG under O Grant O No. O 60118260127 O and O the O Department B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Yunnan I-ORG Province I-ORG under O Grant O No. O 202201AT070118 O This O work O was O supported O by O JST B-ORG CREST I-ORG 14531766 O MEXT B-ORG 15K06916 O and O AMED B-ORG 16ck0106013h0003 O and O 19cm0106536h0002 B-AWARD This O study O was O supported O by O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG funded O project O 2015M581222 O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG CAAS-ASTIP-2015-IAR O and O the O earmarked O fund O for O Modern B-ORG Agro-Industry I-ORG Technology I-ORG Research I-ORG System I-ORG CARDS-45-KXJ1 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O financially O supported O by O the O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2012CB124702 O 2013CB127302 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31272452 O and O the O National B-ORG Key I-ORG Technology I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2011BAD26B01 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Number O 81521091 B-AWARD to O HW O and O Grant O Number O 81602620 B-AWARD to O XC O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG Grant O Number O 17ZR1437900 B-AWARD to O YH) O and O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG China I-ORG Grant O Number O 2017ZX10203204 B-AWARD to O YH O This O work O was O supported O by O the O Fundação B-ORG Araucária I-ORG grant O no. O 340/2014 B-AWARD to O FML O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG grant O no. O 406099/2016-2 B-AWARD to O FML O and O the O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG Bolsista O CAPES-DS O to O JC-S O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O research O was O funded O by O the O Hubei B-ORG Provincial I-ORG Teaching I-ORG and I-ORG Research I-ORG Project I-ORG for I-ORG Higher I-ORG Education I-ORG Hubei I-ORG China O grant O number O 2021085 B-AWARD Teacher B-ORG Education I-ORG Specialized I-ORG Grant I-ORG of I-ORG Central I-ORG China I-ORG Normal I-ORG University O grant O number O CCNUTEIII B-AWARD 2021-10 O and O FoAIE B-ORG “Artificial I-ORG Intelligence I-ORG I-ORG Education” I-ORG Research I-ORG Grant O grant O number O 2022XY017 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81401971 B-AWARD Fujian B-ORG Provincial I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission O Fujian O China O Grant O No. O 2016J01626 B-AWARD Youth B-ORG Foundation I-ORG Project I-ORG of I-ORG Fujian I-ORG Provincial I-ORG Health I-ORG Department I-ORG Grant O No. O 2014-2-69 B-AWARD Scientific B-ORG Research I-ORG Program I-ORG of I-ORG Xiamen I-ORG Grant O No. O 3502Z2015052 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study B-ORG was I-ORG supported I-ORG by I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82260297),the O National O Natural O Science O Foundation O of O China O 81960133 O the B-ORG Yunnan I-ORG University I-ORG Women I-ORG Pelvic I-ORG Floor I-ORG Dysfunction I-ORG Research I-ORG and I-ORG Application I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Team I-ORG K1322112 O Yunnan B-ORG Province I-ORG Clinical I-ORG Research I-ORG Center I-ORG for I-ORG Chronic I-ORG Kidney I-ORG Disease I-ORG No. O 202102AA100060 O This O study O was O supported O by O research O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31301095 O the O Funds B-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG 2013-110 O 2014-379 B-AWARD and O the O Funds B-ORG of I-ORG Heilongjiang I-ORG Postdoctoral I-ORG Financial I-ORG Assistance I-ORG LBH-Z14159 O LBH-Z15165 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O is O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81300635 O the O Shanghai B-ORG Natural I-ORG Science I-ORG Fund I-ORG for I-ORG Youth I-ORG Scholars I-ORG 12ZR1441300 O and O the O Young B-ORG Teachers I-ORG Foundation I-ORG Project I-ORG supported I-ORG by I-ORG the I-ORG Doctorate I-ORG in I-ORG Higher I-ORG Education I-ORG Institutions I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG 20120071120096 O This O study O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC1308300 O Scientific B-ORG Research I-ORG Fund I-ORG of I-ORG Foshan I-ORG Guangdong I-ORG China I-ORG No: O 2016AB003353 O and O the O Clinical B-ORG Research I-ORG Startup I-ORG Program I-ORG of I-ORG Shunde I-ORG Hospital I-ORG Southern I-ORG Medical I-ORG University I-ORG CRSP2019001 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 51402120 B-AWARD and O 51302102 B-AWARD the O Natural B-ORG Science I-ORG Research I-ORG Project I-ORG for I-ORG Colleges I-ORG and I-ORG Universities I-ORG of I-ORG Anhui I-ORG Province O grant O number O KJ2014A222 B-AWARD and O KJ2017ZD31 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Province O grant O number O 1408085QA19 B-AWARD This O research O was O partially O supported O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFA0103200 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81671734 O Key B-ORG Projects I-ORG of I-ORG Tianjin I-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG 18YFZCSY00010 O and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 63191155 O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFA0903400 O Natural O Science O Foundation O of O Jiangsu O Province O of O China O BK20190893 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2019M651984 O A O Project O Funded O by O the O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O and O Lift O Engineering O of O Young O Talents O of O Jiangsu O Association O for O Science O and O Technology O This O work O was O supported O by O The B-ORG National I-ORG Natural I-ORG Science I-ORG Fund I-ORG of I-ORG China I-ORG grant O numbers O 81703239 B-AWARD 81872632 B-AWARD Open B-ORG Fund I-ORG from I-ORG Hubei I-ORG Province I-ORG Key I-ORG Laboratory I-ORG of I-ORG Occupational I-ORG Hazard I-ORG Identification I-ORG and I-ORG Control I-ORG grant O number O OHIC2017Y01 B-AWARD Innovation B-ORG Training I-ORG Program I-ORG for I-ORG College I-ORG Students I-ORG in I-ORG Hubei I-ORG Province I-ORG grant O number O 201810488094 B-AWARD and O Excellent B-ORG young I-ORG and I-ORG middle-aged I-ORG scientific I-ORG research I-ORG and I-ORG innovation I-ORG team I-ORG Fund I-ORG Wuhan I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG grant O number O 2018TDZ03 B-AWARD This O study O was O supported O by O the O Portuguese B-ORG Foundation I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG through O Post-Doc O grant O to O HP O Ref O SFRH/BPD/85249/2012 B-AWARD IPATIMUP O integrates O the O i3S O Research O Unit O which O is O partially O supported O by O FCT O This O work O was O financed O by O FEDER B-ORG I-ORG Fundo I-ORG Europeu I-ORG de I-ORG Desenvolvimento I-ORG Regional I-ORG funds O through O the O COMPETE O 2020 O O Operacional O Programme O for O Competitiveness O and O Internationalisation O POCI O Portugal O 2020 O and O by O Portuguese O funds O through O FCT O O Fundação O para O a O Ciência O e O a O Tecnologia O Ministério O da O Ciência O Tecnologia O e O Inovação O in O the O framework O of O the O project O Institute O for O Research O and O Innovation O in O Health O Sciences O POCI-01-0145-FEDER-007274 O Further O funding O was O obtained O from O the O project O Advancing O cancer O research O from O basic O knowledgment O to O application";NORTE-01-0145-FEDER-000029 O “Projetos O Estruturados O de O I&D&I” O funded O by O Norte B-ORG 2020 I-ORG – I-ORG Programa I-ORG Operacional I-ORG Regional I-ORG do I-ORG Norte O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O in O part O by O Grant O 81070576 B-AWARD from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG and O grant O 12JCZDJC24700 B-AWARD from O the O Tianjin B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG to O WDL O and O by O Grant O 15ZCZDSY00500 B-AWARD from O Tianjin B-ORG Key I-ORG Project I-ORG of I-ORG Scientific I-ORG Support I-ORG to O YW. O This O study O was O supported O by O Beijing B-ORG Postdoctoral I-ORG Research I-ORG Foundation I-ORG 2018-22-115 O Beijing B-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospitals’ I-ORG Youth I-ORG Programme O QML20171202 O and O Beijing B-ORG Health I-ORG System I-ORG Top I-ORG Level I-ORG Health I-ORG Technical I-ORG Personnel I-ORG Training I-ORG Plan I-ORG 20153079 O This O paper O is O funded O by O a O grant O from O the O National B-ORG Oceanic I-ORG and I-ORG Atmospheric I-ORG Administration O Project O R/FM-18 B-AWARD which O is O sponsored O by O the O University O of O Hawaii O Sea O Grant O College O Program O SOEST O under O Institutional O Grant O No. O NA05OAR4171048 B-AWARD to O Brian O W. O Bowen O from O NOAA B-ORG Office I-ORG of I-ORG Sea I-ORG Grant I-ORG Department I-ORG of I-ORG Commerce O Additional O funding O was O provided O by O the O National B-ORG Science I-ORG Foundation I-ORG OCE-15-58852 O to O Brian O W. O Bowen O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Scientific B-ORG and I-ORG Technological I-ORG Programs I-ORG of I-ORG Higher I-ORG Education I-ORG Institutions I-ORG in I-ORG Shanxi I-ORG Grant O No. O 2021L128 B-AWARD the O Applied B-ORG and I-ORG Fundamental I-ORG Research I-ORG Program I-ORG for I-ORG Young I-ORG Scientists I-ORG of I-ORG Shanxi I-ORG Province I-ORG Grant O No. O 20210302124062 B-AWARD the O Technology B-ORG Innovation I-ORG Fund I-ORG of I-ORG Shanxi I-ORG Agricultural I-ORG University I-ORG Grant O No. O 2017YJ20 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 32171806 B-AWARD This O work O was O supported O by O the O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG MOP-130417 O to O JA O and O MOP-102758 B-AWARD to O JBV O Genome O Canada O and O Genome O British O Columbia O for O financial O support O for O the O University B-ORG of I-ORG Victoria-Genome I-ORG BC I-ORG Proteomics I-ORG Centre I-ORG 204PRO O and O 214PRO B-AWARD Leading O Edge O Endowment O Fund O University O of O Victoria O the O Segal O McGill O Chair O in O Molecular O Oncology O at O McGill O University O the O Warren O Y. O Soper O Charitable O Trust O and O the O Alvin O Segal O Family O Foundation O to O the O Jewish O General O Hospital O to O CHB O Max B-ORG Planck I-ORG Society I-ORG and I-ORG DFG I-ORG CRC B-AWARD 1080 O DFG O CRC B-AWARD 902 I-AWARD to O EMS O European B-ORG Research I-ORG Council I-ORG under I-ORG the I-ORG European I-ORG Union’s I-ORG Horizon I-ORG 2020 I-ORG research I-ORG and I-ORG innovation I-ORG program I-ORG 743216 O to I-AWARD EMS I-AWARD and O 727264 B-AWARD EPIPHARM I-AWARD to O ME O Spanish B-ORG Ministerio I-ORG de I-ORG Economia I-ORG y I-ORG Competitividad I-ORG BFU2013-47064-P O and O BFU2016-78232-P B-AWARD to O AVC O and O SAF2014-55000-R B-AWARD to O ME O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III I-ORG and I-ORG co-funded I-ORG by I-ORG European I-ORG Union I-ORG ERDF/ESF O “Investing O in O your O future” O PI15/00663 O and O Miguel O Servet O contract O CPII13/0017]to O OA. O Spanish O Ministerio O de O Educacion O Cultura O y O Deporte O FPU O 13/3870 O to O RCG O Terry B-ORG Fox I-ORG Research I-ORG Institute I-ORG Program I-ORG Project I-ORG TFRI O 1039 O and O Canadian B-ORG Cancer I-ORG Society I-ORG Research I-ORG Institute I-ORG CCSRI O 703489 O to O MH. O European O Community’s O Seventh O Framework O Programme O FP7/2007–2013)/ERC O 268626/EPINORC O project O Integrated O Project O of O Excellence O PIE13/00022 O ONCOPROFILE O CIBER O 2016 O CB16/12/00312 O CIBERONC O the O Spanish O Cancer O Research O Network O RD12/0036/0039 O the O Cellex O Foundation O Obra O Social O “La O Caixa” O and O the O Health B-ORG and I-ORG Science I-ORG Departments I-ORG of I-ORG the I-ORG Catalan I-ORG Government I-ORG Generalitat O de O Catalunya O AGAUR B-AWARD 2014SGR633 I-AWARD to O ME. O ME O is O an O ICREA O Research O Professor O French O Association O of O Rett O Syndrome O funded O research O conducted O by O CEM O HM O and O LK, O genotoul O bioinformatics O platform O Toulouse O Midi-Pyrenees O Bioinfo O Genotoul O provided O computing O and O storage O resources O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81902244 O the O Key B-ORG Program I-ORG of I-ORG Science I-ORG and I-ORG Technique I-ORG Development I-ORG Foundation I-ORG in I-ORG Jiangsu I-ORG Province I-ORG BE2015627 O the O Research B-ORG Project I-ORG of I-ORG Jiangsu I-ORG Provincial I-ORG Health I-ORG Department I-ORG H201528 O the O Jiangsu B-ORG Provincial I-ORG Medical I-ORG Youth I-ORG Talent I-ORG QNRC2016801 O and O Xuzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG KC19063 O This O research O was O financially O supported O by O Special B-ORG Program I-ORG for I-ORG Innovation I-ORG of I-ORG Beijing I-ORG Academy I-ORG of I-ORG Agriculture I-ORG and I-ORG Forestry I-ORG Sciences I-ORG Grant O Nos O KJCX201907-2 B-AWARD JKZX201901 B-AWARD and O KJCX20180204 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31771769 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Beijing I-ORG Municipality I-ORG 5172010 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017M620676 O and O Beijing B-ORG Postdoctoral I-ORG Research I-ORG Foundation I-ORG 2018-ZZ-065 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81703969 O Scientific B-ORG Research I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20160480 O Scientific B-ORG Research I-ORG Foundation I-ORG of I-ORG Yangzhou I-ORG No. O YZ2017074 B-AWARD This O work O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82104491 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Sichuan I-ORG 2023NSFSC0674 O 2022NSFSC0854 B-AWARD the O Postdoctoral B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 2021M693789 O and O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2019YFC1709101 O The O research O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 51363017 B-AWARD and O 51862025 B-AWARD Key B-ORG research I-ORG and I-ORG development I-ORG plan I-ORG of I-ORG Jiangxi I-ORG Province I-ORG 20181BBE58003 O Natural O Foundation O of O Aeronautics O of O China O 20162956005 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Province I-ORG 20192BAB206012 O and O Department O of O Education O fund O of O Jiangxi O Province O GJJ170611 O Rosane O Silva O Fundação O Carlos I-ORG Chagas I-ORG Filho I-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG do I-ORG Rio I-ORG de I-ORG Janeiro—FAPERJ O E-26/200.999/2022 B-AWARD SEI-260003/012994/2021 B-AWARD SEI-260003/001129/2020 B-AWARD Conselho O Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico—CNPQ O 303.829/2019-2 B-AWARD Maria O Clara O da O Costa O Simas O Coordenação O de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nivel I-ORG Superior—Capes O 88887.511767/2020-00 B-AWARD and O Sara O Mesquita O Costa O Capes O 88887.647891/2021-00 B-AWARD This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31500247 O Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG 2018NZ0081 O National B-ORG Student I-ORG Innovation I-ORG Training I-ORG Program I-ORG 201710626030 O and O Undergraduate B-ORG Research I-ORG Interest I-ORG Cultivation I-ORG Project I-ORG of I-ORG Sichuan I-ORG Agricultural I-ORG University I-ORG 2019303 O 2019304 B-AWARD This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG under O Grant O 2022JJ30055 O Social B-ORG Science I-ORG Achievements I-ORG Review I-ORG Committee I-ORG of I-ORG Hunan I-ORG Province I-ORG under O Grant O XSP22ZDI008 O Hunan B-ORG Provincial I-ORG Innovation I-ORG Foundation I-ORG for I-ORG Postgraduate I-ORG QL20220027 O This O project O is O financially O supported O by O the O Research B-ORG Fund I-ORG for I-ORG the I-ORG Doctoral I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG of I-ORG China I-ORG 1014130201120540 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21406087 O 21302069 B-AWARD 21576118 B-AWARD and O Agriculture B-ORG Science I-ORG Technology I-ORG Achievement I-ORG Transformation I-ORG Fund I-ORG 2014GB2A000268 O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31572005 O the O Educational B-ORG Commission I-ORG of I-ORG Hunan I-ORG Province I-ORG of I-ORG China I-ORG 15A090 O and O the O Hunan B-ORG Provincial I-ORG Postgraduate I-ORG Research I-ORG and I-ORG Innovation I-ORG Project I-ORG of I-ORG China I-ORG CX2017B350 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O project O was O jointly O supported O by O the O Sichuan B-ORG Youth I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Team I-ORG Chengdu O China O 2015TD0025 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Beijing O China O 31172198 B-AWARD and O National B-ORG Sci-Tech I-ORG Support I-ORG Plan I-ORG Beijing O China O 2014BAD13B03 B-AWARD to O MJ. O The O work O corresponding O to O Xiaodi O Yang O and O Qiang O Fang O was O supported O by O the B-ORG Key I-ORG Supporting I-ORG Project I-ORG of I-ORG Prominent I-ORG Youth I-ORG in I-ORG Universities I-ORG of I-ORG Anhui I-ORG gxyqZD2016159 O and O by O the B-ORG Science I-ORG Research I-ORG Innovation I-ORG Team I-ORG Project I-ORG of I-ORG Anhui I-ORG Colleges I-ORG and I-ORG Universities I-ORG 2016-40 O The O work O corresponding O to O Xiaoli O Wang O and O Liang O Li O was O supported O by O the B-ORG Key I-ORG Projects I-ORG of I-ORG Science I-ORG Research I-ORG in I-ORG Education I-ORG Institutes I-ORG of I-ORG Anhui I-ORG Colleges I-ORG and I-ORG Universities I-ORG KJ2016A708 O KJ2015B034by O and O by O the B-ORG Key I-ORG Projects I-ORG of I-ORG Science I-ORG Research I-ORG of I-ORG Bengbu I-ORG College I-ORG 2017ZR01 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O jointly O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O Number O 2019YFC1509201 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Number O 41374028 B-AWARD and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O Number O 310826175018 B-AWARD This O work O was O financially O supported O by O the O Youth B-ORG Talent I-ORG Development I-ORG Plan I-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Agricultural I-ORG System I-ORG Grant O No. O 20170116 B-AWARD to O RL, O Shanghai B-ORG Agriculture I-ORG Applied I-ORG Technology I-ORG Development I-ORG Program I-ORG Grant O No.Z20170303 O to O Y. O Lin O and O the O Young B-ORG Scientist I-ORG Plan I-ORG of I-ORG Shanghai I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG Grant O No. O ZP173 B-AWARD to O RL. O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 51932006 B-AWARD 51521001 B-AWARD and O 51769028 B-AWARD the O 111 B-ORG Project I-ORG Grant O No. O B13035 B-AWARD the O Joint B-ORG Fund I-ORG Grant O No. O 6141A02022255 B-AWARD The O design O of O the O study O sample O collection O sequencing O data O interpretation O and O the O writing O of O the O manuscript O were O funded O by O the B-ORG Key I-ORG Projects I-ORG in I-ORG the I-ORG National I-ORG Science I-ORG I-ORG Technology I-ORG Pillar I-ORG Program I-ORG No.2015BAI09B02 O data O analysis O was O funded O by O the B-ORG National I-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.31700923 O animal O breeding O for O laboratory O animalization O was O funded O by O the O Shanghai B-ORG Committee I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG No.16140900100 O and O No.17140900200 O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O 81570703 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No.106112017CDJ O the B-ORG National I-ORG Science I-ORG Foundation I-ORG for I-ORG Young I-ORG Scholars I-ORG 81704090 O and O Key B-ORG projects I-ORG of I-ORG Chongqing I-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG cstc2017jcyjbx0044 O Both O projects O are O not O in O a O financial O or O personal O relationship O to O this O study O The O ENVIRONAGE O birth O cohort O is O supported O by O the O European B-ORG Research I-ORG Council I-ORG ERC-2012-StG.310898 O by O the O Flemish B-ORG Scientific I-ORG Fund I-ORG FWO O G.0.733.15.N O and O the O Special O Research O Fund O BOF O of O Hasselt O University O This O work O was O also O supported O by O funding O from O the O National B-ORG Institute I-ORG of I-ORG Environmental I-ORG Health I-ORG Sciences I-ORG R21ES022694 O and O R01ES021733 B-AWARD This O study O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31 O 370 I-AWARD 707 I-AWARD and O 31000322 B-AWARD Project B-ORG of I-ORG China I-ORG Agricultural I-ORG Research I-ORG System I-ORG CARS-34 O and O Agricultural B-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG Project I-ORG of I-ORG Shandong I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG CXGC2016B10 O Supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG Project I-ORG Funding I-ORG 2018YFD1000607 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31772285 O and O Hebei B-ORG Distinguished I-ORG Young I-ORG Scholar I-ORG C2016204145 O These O funding O bodies O had O no O role O in O the O design O of O the O study O sample O collection O analysis O or O interpretation O of O data O and O in O writing O the O manuscript O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq O Brazil O 306323/2018-4 B-AWARD 312595/2019-0 B-AWARD 439344/2018-2 B-AWARD 315879/2021-1 B-AWARD 409196/2022-3 B-AWARD 408110/2022-8 B-AWARD and O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo I-ORG Brazil I-ORG FAPESP I-ORG 2014/50945-4 B-AWARD and O 2019/13113-4 B-AWARD The O APC O was O funded O by O CNPq B-ORG Process I-ORG 116925/2022-1 B-AWARD PDJ O This O work O was O supported O by O the O National B-ORG Institute I-ORG of I-ORG Health O grant O K01 B-AWARD HL149989 O to O KNT O The O funding O was O provided O by O National B-ORG Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute I-ORG NHLBI)—The O Programs O to O Increase O Diversity O among O Individuals O Engaged O in O Health-Related O Research O PRIDE)—Impact O of O Ancestry O and O Gender O on O Omics O of O Lung O Diseases O AGOLD)—Small O Research O Project O to O KNT O through O R25HL146166 B-AWARD Support O was O also O provided O by O NIH-NCRR B-ORG grant O 1S10OD010366-01A1 B-AWARD and O R01HL123385 B-AWARD to O N.R O In O addition O the O authors O appreciate O the O contribution O to O this O research O made O by O E. O Erin O Smith O HTL O ASCP O CM O QIHC O Allison O Quador O HTL O ASCP O CM; O and O Jessica O Arnold O HTL O ASCP O CM O of O the O University O of O Colorado O Cancer B-ORG Center I-ORG Pathology O Shared O Resource O and O the O Genomics O Core O This O resource O was O supported O in O part O by O the O Cancer O Center O Support O Grant O P30CA046934 O The O funding O agencies O did O not O have O any O role O in O the O study O design O collection O analysis O and O interpretation O of O data O the O writing O of O this O report O or O the O decision O to O submit O for O publication O This O work O was O supported O by O the O Grants O from O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Pulp I-ORG and I-ORG Paper I-ORG Engineering I-ORG Nos O 2018TS06 B-AWARD 2017C02 B-AWARD and O 2017PY01 B-AWARD and O Program O for O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 21576103 B-AWARD and O Young O scholars O of O Yangtze O River O Scholar O from O the O Ministry O of O Education O China O and O The O Guangdong O Program O for O Support B-ORG of I-ORG Top-notch I-ORG Young I-ORG Professionals I-ORG No. O 2016TQ03Z585 B-AWARD Guangzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG No. O 201707010059 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG SCUT O China O No. O 2017ZD081 B-AWARD This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81773190 B-AWARD 81774029 B-AWARD Jiangsu B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG Social I-ORG Development I-ORG Fund I-ORG No. O BE2011846 B-AWARD the O Open B-ORG Project I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Key I-ORG Laboratory I-ORG for I-ORG Pharmacology I-ORG and I-ORG Safety I-ORG Evaluation I-ORG of I-ORG Chinese I-ORG Materia I-ORG Medica I-ORG No. O JKLPSE201809 B-AWARD and O the O Project B-ORG of I-ORG the I-ORG Priority I-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O No. O JKLPSE201605 B-AWARD This O research O was O supported O by O Jilin B-ORG Province I-ORG Education I-ORG Department I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG during I-ORG the I-ORG Thirteenth I-ORG Five-year I-ORG Plan I-ORG Period O Grant/Award O Number O JJKH20190940KJ B-AWARD Scientific B-ORG Research I-ORG Fund I-ORG Project I-ORG of I-ORG Jilin I-ORG Agricultural I-ORG University O Grant/Award O Number O 201801 B-AWARD Science B-ORG and I-ORG Technology I-ORG Development I-ORG Plan I-ORG Project I-ORG of I-ORG Jilin I-ORG Province O Grant/Award O Number O 20190301009NY B-AWARD Science B-ORG and I-ORG Technology I-ORG Development I-ORG Plan I-ORG projects I-ORG of I-ORG Jilin I-ORG Province O Grant/Award O Number O 20170307007YY B-AWARD This O work O was O supported O by O the O following O grants O Deutsche B-ORG Forschungsgemeinschaft I-ORG DFG O SFB824/3 O DFG O STA O 1520/1-1 O BMBF B-ORG Innovative O Therapies O 01GU0823 O BMBF O Kompetenzverbund O Strahlenforschung O 02NUK038A O BMWi B-ORG AiF O ZF4320102CS7 B-AWARD ZF4320104AJ8 B-AWARD National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG no. O 2017YFE0111500 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 51673123 B-AWARD and O 51222305 B-AWARD and O Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG no. O 2016JQ0049 B-AWARD We O received O funds O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81571184 B-AWARD 81070990 B-AWARD 30670719 B-AWARD 30500525 B-AWARD and O the O Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG Nos O 15140902100 B-AWARD 10QH1401700 B-AWARD in O the O process O of O study O design O experiment O implementation O and O data O collection O Data O interpretation O and O article O writing O were O supported O by O the O grants O from O the O Shanghai O Science O and O Technology O Commission O No. O 09140901300 B-AWARD and O the O Shanghai B-ORG Municipal I-ORG Education I-ORG Commission I-ORG No. O 09SG20 B-AWARD This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81673179 B-AWARD 81402687 I-AWARD 81602860 I-AWARD 81703233 O The O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG grant O number O 18140903100 B-AWARD 19140903100 O the O Shanghai B-ORG Sailing I-ORG Program I-ORG grant O number O 18Y1419600 B-AWARD Shanghai B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG grant O number O 20174Y0010 B-AWARD 20184Y0078 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG grant O number O 22120180038 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31872851 O the O Innovative B-ORG Research I-ORG Groups I-ORG of I-ORG the I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG 2019JJ10003 O and O Hunan B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 2018JJ3305 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O article O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC1301600 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG to O Yi O Yang O Grant O No. O 81571123 B-AWARD and O JLUSTIRT B-ORG 2017TD-12 O to O Yi O Yang O The O funding O bodies O played O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O paper O was O supported O by O the O European B-ORG Research I-ORG Council I-ORG project O No O 726318 B-AWARD Marie B-ORG Curie I-ORG CIG I-ORG No. O 631773 B-AWARD and O British B-ORG Heart I-ORG Foundation I-ORG Centre O for O Research O Excellence O RE/13/5/30177 O This O work O was O sponsored O by O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG 2018J01264 O Fujian B-ORG provincial I-ORG health I-ORG technology I-ORG project I-ORG 2017-CXB-2 O and O Joint B-ORG Funds I-ORG for I-ORG the I-ORG innovation I-ORG of I-ORG science I-ORG and I-ORG Technology I-ORG Fujian I-ORG province I-ORG 2017Y9076 O and O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Fujian I-ORG Province I-ORG 2018Y2003 O This O work O was O founded O by O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BE2017626 O the B-ORG Six I-ORG talent I-ORG peaks I-ORG project I-ORG in I-ORG Jiangsu I-ORG Province I-ORG WSN-186 O and O the B-ORG Foundation I-ORG of I-ORG Wuxi I-ORG Health I-ORG Commission I-ORG QNRC003 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82171025 O 82070934 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG HUST O 2019kfyXMBZ065 O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Hubei I-ORG Province I-ORG 2021BCA146 O and O the O Clinical B-ORG Research I-ORG Foundation I-ORG of I-ORG Wuhan I-ORG Union I-ORG Hospital I-ORG 2021xhlcyj03 O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31301358 B-AWARD the O Scientific B-ORG and I-ORG Technological I-ORG Cooperation I-ORG Projects I-ORG of I-ORG Hainan I-ORG province I-ORG No. O KJHZ2015-06 B-AWARD and O the O Fundamental B-ORG Scientific I-ORG Research I-ORG Funds I-ORG for I-ORG Chinese I-ORG Academy I-ORG of I-ORG Tropical I-ORG Agricultural I-ORG Sciences I-ORG No. O 1630152019006 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Science I-ORG I-ORG Technology I-ORG Pillar I-ORG Program I-ORG of I-ORG Sichuan I-ORG 2014FZ0004 O 2016NZ0042 O the B-ORG State-level I-ORG Spark I-ORG Program I-ORG of I-ORG China I-ORG 2015GA810006 O the B-ORG Foundation I-ORG for I-ORG Young I-ORG Scholars I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2014JQ0054 O and O the O Youth B-ORG Foundation I-ORG Program I-ORG of I-ORG the I-ORG Financial I-ORG I-ORG Innovational I-ORG Capacity I-ORG Building I-ORG Project I-ORG of I-ORG Sichuan I-ORG 2014CXSF-030 O The O research O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 51805176 B-AWARD the O National B-ORG Technology I-ORG Development I-ORG Project I-ORG in I-ORG Fujian I-ORG Province I-ORG Grant O No. O 2021L3012 B-AWARD and O the O Promotion B-ORG Program I-ORG for I-ORG Young I-ORG and I-ORG Middle-aged I-ORG Teachers I-ORG in I-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG at I-ORG Huaqiao I-ORG University I-ORG Grant O No. O ZQN-PY601 B-AWARD This O work O was O supported O by O the O Brazilian B-ORG agencies I-ORG CAPES I-ORG Finance O Code O 001 B-AWARD CNPq B-ORG Grant O 302807/2019-5 B-AWARD and O FAPERJ B-ORG Grant O E26/202.905/2017 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Award O No.81970501 B-AWARD National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Grant O No.2017YFC0908300 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province I-ORG 2019-MS-388 O This O study O was O supported O by O “Science O and I-ORG Technology I-ORG Plan I-ORG Projects I-ORG in I-ORG Xinjiang” O 2014AB043 O “Prospective O joint I-ORG research I-ORG project I-ORG of I-ORG Jiangsu I-ORG Province” O BY2016078-02 O “One O Hundred I-ORG Person I-ORG Project I-ORG of I-ORG The I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Applied I-ORG Basic I-ORG Research I-ORG Programs I-ORG of I-ORG Qinghai I-ORG Province” O 2015-ZJ-733 O “State O Key I-ORG Laboratory I-ORG of I-ORG Molecular I-ORG Oncology I-ORG Cancer I-ORG Hospital” O SKL-KF-2017-04 O This O study O was O supported O in O part O by O China B-ORG Medical I-ORG University I-ORG under O the B-AWARD Higher I-AWARD Education I-AWARD Sprout I-AWARD Project I-AWARD Ministry I-AWARD of I-AWARD Education I-AWARD Taiwan O It O was O also O supported O by O the O Taiwan B-ORG Ministry I-ORG of I-ORG Health I-ORG and I-ORG Welfare I-ORG Clinical I-ORG Trial I-ORG and I-ORG Research I-ORG Center I-ORG of I-ORG Excellence I-ORG MOHW107-TDU-B-212-123004 O the B-ORG Health I-ORG and I-ORG Welfare I-ORG surcharge I-ORG of I-ORG tobacco I-ORG product I-ORG China I-ORG Medical I-ORG University I-ORG Hospital I-ORG Cancer I-ORG Research I-ORG Center I-ORG of I-ORG Excellence I-ORG MOHW107-TDU-B-212-114-24 O and O Department O of O Medical O Research O China O Medical O University O Hospital O DMR-107-004 O Taiwan O J.X O was O supported O by O fellowship O 201908440228 B-AWARD from O the O China B-ORG Scholarship I-ORG Council O M.V O by O grant O VI.Veni.192.151 B-AWARD from O the O Dutch B-ORG Research I-ORG Council I-ORG Nederlandse O Organisatie O voor O Wetenschappelijk O Onderzoek O NWO B-ORG P.v.H O and O A.H.M O by O NWO O grant O OCENW.M20.241 B-AWARD and O M.v.d.V O and O A.H.M O by O NWO-TTW B-ORG grant O 13259 B-AWARD from O the O NWO O Domain O Applied O and O Engineering O Sciences O This O work O was O supported O by O the O US O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health I-ORG grant O no. O 2P50MH094258 B-AWARD and O a O Chen B-ORG Institute I-ORG Award O grant O no. O P2026052 B-AWARD Merkin O Institute O grant O DM1.COV19R1 O and O Templeton O Foundation O grant O TWCF0366 O both O to O D.M O T.W O is O supported O by O a O Wellcome B-ORG Trust I-ORG Sir O Henry O Wellcome O Fellowship O grant O no. O 206460/17/Z B-AWARD T.D.Z O is O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG grant O no. O 1911441 B-AWARD This O work O was O supported O in O part O by O New B-ORG Century I-ORG Excellent I-ORG Talent I-ORG Support I-ORG Plan I-ORG NCET-13-0488 O the O Twelve-five B-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG No.2015BAD16B08 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31301498 O International B-ORG Collaboration I-ORG Partner I-ORG Plan I-ORG A213021203 O in O Northwest O A&F O University O and O Special B-ORG Fund I-ORG for I-ORG Sino-US I-ORG Joint I-ORG Research I-ORG Center I-ORG for I-ORG Food I-ORG Safety I-ORG A200021501 O This O research O was O supported O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2020YFB0408100 O NSFC B-ORG U20A20340 O the B-ORG Program I-ORG for I-ORG Guangdong I-ORG Introducing I-ORG Innovative I-ORG and I-ORG Entrepreneurial I-ORG Team I-ORG 2016ZT06C412 O Foshan B-ORG Introducing I-ORG Innovative I-ORG and I-ORG Entrepreneurial I-ORG Teams I-ORG No. O 1920001000108 B-AWARD the B-ORG Hundred I-ORG Talent I-ORG Program I-ORG of I-ORG Guangdong I-ORG University I-ORG of I-ORG Technology I-ORG 220418095 O Guangzhou B-ORG Hongmian I-ORG Project I-ORG HMJH-2020-0012 O We O want O to O thank O Tingting O Cui O for O assisting O in O simulation O calculations O This O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 31871127 B-AWARD to O W.P O and O 31871109 B-AWARD to O F.C O Shenzhen B-ORG Basic I-ORG Research I-ORG Project I-ORG JCYJ20170818093231953 O to O W.P O and O Shenzhen B-ORG University I-ORG Natural I-ORG Science I-ORG Research I-ORG Fund I-ORG 2017073 O to O W.P O This O work O was O supported O by O European B-ORG Union I-ORG Seventh I-ORG Framework I-ORG Program I-ORG Marie I-ORG Curie I-ORG Career I-ORG Integration I-ORG Grant O 322130 B-AWARD Caritro B-ORG “Ricerca I-ORG Biomedica” I-ORG Grant O 2013.0248 B-AWARD both O to O M.P O by O grant O R01AI129706 B-AWARD from O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG USA I-ORG to O J.G O as O well O as O by O the O Deutsche B-ORG Forschungsgemeinschaft I-ORG DFG O German O Research O Foundation O SPP O 1923 O grant O FA378-17-2 B-AWARD and O the O German B-ORG Centre I-ORG for I-ORG Infection I-ORG Research I-ORG DZIF O TTU O 04.810—An O integrated O approach O for O HIV-cure O “Shock O and O Kill” O to O O.T.F O We O thank O The O Pendleton O Charitable O Trust O for O the O equipment O This O work O was O funded O by O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III I-ORG http://www.isciii.es O PI12/02877 O FA O including O FEDER O funds O and O by O Fundación B-ORG Salud I-ORG 2000 I-ORG http://www.fundacionmercksalud.com O Ayuda O Merck I-AWARD Serono I-AWARD de I-AWARD Investigación I-AWARD en I-AWARD Oncología I-AWARD 2012 O FA O EN O was O funded O by O Spain O Ministerio B-ORG de I-ORG Educación I-ORG Cultura I-ORG y I-ORG Deporte I-ORG https://www.mecd.gob.es O FPU16/06537 O The O funding O bodies O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O Ministerio B-ORG de I-ORG Sanidad I-ORG Servicios I-ORG Sociales I-ORG e I-ORG Igualdad O Ministerio O de O Economía O y O Competitividad O BFU2016-68556R O Delegación O del O Gobierno O para O el O Plan O Nacional O Sobre O Drogas O Proyectos O de O Investigación O sobre O Drogodependencias O 2018I013 O Generalitat B-ORG Valenciana O PROMETEO/2018/132 B-AWARD Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III I-ORG Red I-ORG de I-ORG Trastornos I-ORG Adictivos I-ORG RTA O RD12/0028/0005 O and I-AWARD RD16/0017/0007 O and O Unión O Europea O Fondos O FEDER O “una O manera O de O hacer O Europa” O D.D.R O is O supported O by O a O Grant O from O FUSP-CEU O This O work O was O financially O supported O by O the O projects O of O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 81473545 B-AWARD The O National O Science O Foundation O of O China O grant O no. O 81601825 B-AWARD Program B-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Liaoning I-ORG Province I-ORG grant O no. O 201601237 B-AWARD China B-ORG Scholarship I-ORG Fund I-ORG no. O 201808210086 B-AWARD and O Liaoning B-ORG province I-ORG plans I-ORG to I-ORG support I-ORG innovative I-ORG talents I-ORG in I-ORG Colleges I-ORG and I-ORG Universities I-ORG no. O LR2017050 B-AWARD EJT O contributed O to O this O project O whilst O seconded O to O Scottish O Government O as O part O of O her O NHS O specialty O training O in O public O health O and O completed O production O of O this O article O with O the O support O of O a O CSO O Clinical B-ORG Academic I-ORG Fellowship I-ORG CAF/17/11 O and O funding O from O the O Medical B-ORG Research I-ORG Council I-ORG MC_UU_12017/13 O O MC_UU_12017/15 B-AWARD and O Chief B-ORG Scientist I-ORG Office I-ORG SPHSU13 O I-AWARD SPHSU15 O RM O contributed O to O this O project O whilst O on O a O Scottish O Graduate O School O of O Social O Science O professional O internship O with O Scottish O Government O completing O the O production O of O this O article O with O the O support O of O the O Economic O and O Social O Research O Council O Funding O for O transcription O of O the O additional O interviews O from O the O Older O People O with O Drug O Problems O project O and O their O secondary O analysis O was O provided O by O the O Scottish O Government O Substance O Misuse O Unit O LB O contributed O to O this O project O and O production O of O this O article O while O working O for O Information O Services O Division O now O part O of O Public O Health O Scotland O Funding O in O our O group O is O supported O by O the O grants O IDI/2018/000236 B-AWARD from O the O Principality B-ORG of I-ORG Asturias O AGL2016-78311-R B-AWARD AEI/FEDER O UE) O from O the O Ministry O of O Economy O and O Competitiveness O MINECO O and O RTI2018-096339-B-I00 B-AWARD and I-AWARD RTI2018-095021-J-I00 I-AWARD MCIU/AEI/FEDER O UE O This O work O was O supported O byStichting O Vrienden I-ORG van I-ORG het I-ORG Sophia[Grant O Number O 985 B-AWARD to O JCE];Stichting O Crohn I-ORG en I-ORG Colitis I-ORG Ulcerosa I-ORG Fonds I-ORG Nederland/Maag O Lever O Darm O Stichting[Grant O Number O 14.307.04 B-AWARD to O EMWJU];Fonds O NutsOhra[Grant O Number O 1303-012 B-AWARD to O EMWJU O andStichting O Theia[Grant O Number O 2013201 B-AWARD to O EMWJU O This O work O was O funded O in O part O by O grants O from O the O National O Institutes O of O Health O National O Institute I-ORG of I-ORG Arthritis I-ORG and I-ORG Musculoskeletal I-ORG and I-ORG Skin I-ORG Diseases I-ORG Grant O No. O P30-AR072582 B-AWARD P60-AR062755 B-AWARD K01-AR067280 B-AWARD R21-AR067459 B-AWARD and O K24-AR068406 B-AWARD National B-ORG Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences I-ORG Grant O No. O UL1-TR001450 B-AWARD and O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG Grant O No. O U54-GM104941 O G.H O is O grateful O for O support O from O the O Medical O University O of O South O Carolina O College O of O Medicine O start-up O funds O and O the O National O Institute O of O General O Medical O Sciences O Grant O No. O R01-GM122078 B-AWARD and O the O National B-ORG Cancer I-ORG Institute I-ORG Grant O No. O R21-CA209848 B-AWARD This O work O was O supported O by O the O Science B-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Gui I-ORG Zhou I-ORG Province I-ORG (2019)2827 O 2015)4015 B-AWARD 2018)5706 B-AWARD Doctoral B-ORG Foundation I-ORG of I-ORG Guizhou I-ORG Provincial I-ORG People’s I-ORG Hospital I-ORG GZSYBS(2015)12 O Non-profit B-ORG Central I-ORG Research I-ORG Institute I-ORG Fund I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG 2019PT320003 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O of O the O Austrian B-ORG Science I-ORG Fund I-ORG FWF O P B-AWARD 34253-B O the O Science B-ORG and I-ORG Technology I-ORG Assistance I-ORG Agency I-ORG of I-ORG the I-ORG Slovak I-ORG Republic I-ORG APVV-20-0513 O and O the O Slovak B-ORG Grant I-ORG Agency I-ORG VEGA I-ORG 2/0152/21 O This O work O was O financially O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD1000607 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31372019 O the O Beijing B-ORG Forestry I-ORG University I-ORG 2018BLRD O The O funding O bodies O were O not O involved O in O the O design O of O the O study O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG C2013205103 O the O Out-standing B-ORG youth I-ORG Foundation I-ORG of I-ORG Department I-ORG of I-ORG Education I-ORG of I-ORG Hebei I-ORG Province I-ORG YQ2014026 O the O Research B-ORG Fund I-ORG of I-ORG Hebei I-ORG Normal I-ORG University I-ORG L2016Z03 O the B-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Pathogen I-ORG and I-ORG Biosecurity I-ORG Academy O of O Military O Medical O Science O SKLPBS1529 O and O the B-ORG Science I-ORG and I-ORG technology I-ORG research I-ORG project I-ORG of I-ORG Hebei I-ORG University I-ORG ZD2018070 O This O research O received O no O external O funding O The O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.12004285 O the O Guangdong B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.2021A1515011935 O the O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG No.(2019A1515111190 O and O the O Guangdong B-ORG Innovation I-ORG and I-ORG Strengthening I-ORG School I-ORG Project I-ORG Foundation I-ORG No.2022ZDZX3033 O Guangdong B-ORG Engineering I-ORG Technology I-ORG Research I-ORG Center I-ORG No.2021J020 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81672416 O 81572075 B-AWARD 81670502 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Jiangsu I-ORG Province I-ORG BK20141303 O Jiangsu B-ORG Province’s I-ORG Major I-ORG Project I-ORG in I-ORG Research I-ORG and I-ORG Development I-ORG BE2015667 O BE2017694 O the O Key O Research O and O Development O Project O of O Zhenjiang O SH2015034 O Major O Natural O Science O Reasearch O Project O for O Universities O in O Jiangsu O Province O 18KJA320001 O Jiangsu O Province’s O 333 O project O Funds O for O Young O Academic O Leader O of O Jiangsu O University O Startup O Funds O for O Senior O Talents O of O Jiangsu O University O 13JDG086 O The O authors O gratefully O acknowledge O the O financial O assistance O provided O by O the O Scientific B-ORG Research I-ORG Foundation I-ORG of I-ORG Tangshan I-ORG Normal I-ORG University I-ORG No. O 2021A03 B-AWARD the O Key B-ORG Cultivation I-ORG Project I-ORG of I-ORG Tangshan I-ORG Normal I-ORG University I-ORG No. O ZDPY05 B-AWARD the O Key B-ORG Project I-ORG for I-ORG Scientific I-ORG Research I-ORG in I-ORG Colleges I-ORG and I-ORG Universities I-ORG of I-ORG Hebei I-ORG Province I-ORG No. O ZD2021408 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG No. O 2021105001 B-AWARD Funded O by O a O grant O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31300551 O the O Young B-ORG Talent I-ORG Support I-ORG Program I-ORG from I-ORG the I-ORG Association I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Colleges I-ORG in I-ORG Shaanxi I-ORG Province I-ORG 20160235 O and O the O Special B-ORG Foundation I-ORG for I-ORG Young I-ORG Scientists I-ORG of I-ORG Weinan I-ORG Normal I-ORG University I-ORG 15ZRRC03 O This O work O was O financial O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grants O 21878104 B-AWARD 31800063 B-AWARD and O U1701243 O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFA0901504 O the O Project B-ORG on I-ORG the I-ORG Integration I-ORG of I-ORG Industry I-ORG Education I-ORG and I-ORG Research I-ORG of I-ORG Guangzhou I-ORG China I-ORG Grants O 201704020183 B-AWARD and O 201903010086 B-AWARD and O the B-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG Grant O 2017A010105019 B-AWARD This O study O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81672250 B-AWARD Zhejiang B-ORG Natural I-ORG Science I-ORG Foundation I-ORG NO. O LQ15H010002 B-AWARD and O Project B-ORG of I-ORG Wenzhou I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau(Y20140084 O Financial O support O for O this O study O was O provided O by O the O Program B-ORG for I-ORG Key I-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG Team I-ORG in I-ORG Shaanxi I-ORG Province I-ORG grant O no. O 2017KCT-19-01 B-AWARD Key B-ORG Industrial I-ORG Chain I-ORG Group I-ORG Project I-ORG of I-ORG Shaanxi I-ORG Province I-ORG grant O no. O 2017ZDCXL-GY-07-02 B-AWARD and O Leading B-ORG Project I-ORG of I-ORG Technology I-ORG Innovation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG grant O no. O 2018HJCG-18 B-AWARD Youhua O Chen O was O supported O by O the O Hundred B-ORG Talents I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Y8C3041100 O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDA19050201 O and O National B-ORG Key I-ORG Programme I-ORG of I-ORG Research I-ORG and I-ORG Development I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2017YFC0505202 O Yongbin O Wu O was O funded O by O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG No. O 2015A020209131 B-AWARD and O the O Innovation B-ORG of I-ORG Forestry I-ORG Science I-ORG and I-ORG Technology I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG China I-ORG No. O 2008KJCX010-3 B-AWARD 2012KJCX014-01 I-AWARD 2015KJCX021 O Tsung-Jen O Shen O was O supported O by O the O Taiwan B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG under I-ORG contract I-ORG MOST I-ORG 106-2118-M-005-002 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O grants O from O the O Diputació O de O Lleida O Generalitat B-ORG de I-ORG Catalunya I-ORG 2017SGR696 O and I-AWARD SLT0021600250 O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III I-ORG Fondo O de O Investigación O Sanitaria O PI12/00803 B-AWARD and I-AWARD PI15/00260 O and O European B-ORG Union I-ORG European O Regional I-AWARD Development I-AWARD Fund O Fondo O Europeo O de O Desarrollo O Regional O “Una O manera O de O hacer O Europa” O CIBER O de O Diabetes O y O Enfermedades O Metabólicas O Asociadas O CIBER O de O Nutrición O y O Obesidad O and O CIBER O de O Enfermedades O Respiratorias O are O initiatives O of O the O Instituto O de O Salud O Carlos O III O The O study O was O supported O by O the O European O Union’s O Sixth B-ORG Framework I-ORG Programme I-ORG Network O of O Excellence O InGenious O HyperCare O grant O agreement O LSHM-CT-2006-037093 B-AWARD the O Seventh B-ORG Framework I-ORG Programme I-ORG Collaborative O Projects O EU-MASCARA O grant O agreement O 278249 B-AWARD and O HOMAGE O grant O agreement O 305507 B-AWARD and O the O British B-ORG Heart I-ORG Foundation I-ORG Chair O and O Programme O Grant O RG/07/005/23633 B-AWARD This O research O was O supported O by O the B-ORG National I-ORG Support I-ORG Program I-ORG of I-ORG China I-ORG No. O 2015BAD27B01 O the B-ORG Technological I-ORG Innovation I-ORG and I-ORG Over I-ORG Planning I-ORG Projects I-ORG of I-ORG Shaanxi I-ORG Province I-ORG No. O 2014KTZB02-01-02 O and O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31771785 O This O work O was O supported O by O Sundhed B-ORG og I-ORG Sygdom I-ORG Det I-ORG Frie I-ORG Forskningsråd I-ORG 4004-00140B O Dr O Jesper O Thorvald O Troelsen O University B-ORG of I-ORG Copenhagen I-ORG Excellence I-ORG Programme I-ORG for I-ORG Interdiciplinary I-ORG Research I-ORG CDO2016 O Dr O Eric O Paul O Bennett O and O Danmarks B-ORG Grundforskningsfond I-ORG DNRF107 O Dr O Eric O Paul O Bennett O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0101804 O Hongyuan O Song O receive O the O funding O the B-ORG China I-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2015M582500 O and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG in I-ORG China I-ORG XDJK2016C080 O the B-ORG Chongqing I-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Xm2016029 O Qinfei O Li O receive O these O three O funding O the B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG Chongqing I-ORG cstc2015shms-ztzx80005 O cstc2015shms-ztzx80007 I-AWARD and I-AWARD cstc2015shms-ztzx80009 O Hongyuan O Song O receive O these O fundings O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O project O was O funded O by O the O Natural B-ORG Science I-ORG Research I-ORG Project I-ORG of I-ORG Anhui I-ORG Colleges I-ORG and I-ORG Universities I-ORG Reference O No: O KJ2016A373 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG Reference O Nos O 2013A022100036 B-AWARD and O 2014A020212257 B-AWARD and O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG City I-ORG Reference O No: O 201704020079 B-AWARD This O work O was O funded O by O the B-ORG key I-ORG scientific I-ORG and I-ORG technological I-ORG project I-ORG of I-ORG Henan I-ORG Province I-ORG 192102110023 O and O 30601916 B-AWARD to O DZ, O the O Key B-ORG Scientific I-ORG Research I-ORG Projects I-ORG of I-ORG Higher I-ORG Education I-ORG Institutions I-ORG in I-ORG Henan I-ORG Province I-ORG 20A210017 O to O DZ, O the O Henan B-ORG agricultural I-ORG university I-ORG science I-ORG and I-ORG technology I-ORG innovation I-ORG fund I-ORG KJCX2019C02 O to O DZ, O the O Innovative B-ORG Research I-ORG Group I-ORG Project I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG CN) O 31701309 O to O HL, O and O the O Ministry O of O Science O and O Technology O of O China O 2016YFD0100500 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81802994 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC)/Research I-ORG Grants I-ORG Council I-ORG RGC I-ORG Joint I-ORG Research I-ORG Scheme I-ORG 81761168038 O Beijing B-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospitals’ I-ORG Mission I-ORG Plan I-ORG SML20180501 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O Grant/Award O Number O 31872800 B-AWARD 31801124 B-AWARD 31701299 B-AWARD 31701288 B-AWARD Foundation O of O Guangzhou O Science O and O Technology O Commission O Grant/Award O Number O 201803040009 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O Grant/Award O Number O 2014A030312012 B-AWARD Guangdong O Province O Science O and O Technology O Project O Grant/Award O Number O 2016B030229008 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation O Grant/Award O Number O 2018M633029 B-AWARD 2018T110858 B-AWARD 2018M64077 B-AWARD This O work O was O supported O by O grants O to O HW O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG nos O 81273257 B-AWARD and O 81471584 B-AWARD the O Tianjin B-ORG Application I-ORG Basis I-ORG and I-ORG Cutting-Edge I-ORG Technology I-ORG Research I-ORG Grant I-ORG no. O 14JCZDJC35700 B-AWARD the O Li B-ORG Jieshou I-ORG Intestinal I-ORG Barrier I-ORG Research I-ORG Special I-ORG Fund I-ORG no. O LJS_201412 B-AWARD and O the O Tianjin O Medical O University O Talent O Fund O This O work O has O been O supported O by O the O Engineering B-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG Grant O EP/1038099/1 B-AWARD CDT O the O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG Grants O BB/M006891/1 B-AWARD EMPATHY O BB/P025684/1 B-AWARD and O Defense B-ORG Advanced I-ORG Research I-ORG Projects I-ORG Agency I-ORG Grant O DARPA-BAA-14-14 B-AWARD Cardiff O University O researchers O were O supported O by O Medical B-ORG Research I-ORG Council I-ORG MRC I-ORG Centre I-ORG G0800509 O and O Programme O Grant O G0801418 O This O study O was O supported O by O the O NIMH B-ORG PGC I-ORG grant O 5U01MH109514-02 O The O EU-GEI O Project O was O funded O by O the O European B-ORG Community’s I-ORG Seventh I-ORG Framework I-ORG Programme I-ORG under O grant O agreement O HEALTH-F2-2010–241909 B-AWARD Project O EU-GEI O This O article O represents O independent O research O part O funded O by O the O National O Institute O for O Health O Research O NIHR O Biomedical O Research O Centre O at O South O London O and O Maudsley O National O Health O Service O Foundation O Trust O and O King’s O College O London O This O study O was O jointly O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG 2017YFD0500503 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31772613 O 31572421 B-AWARD and O 31772617 B-AWARD and O the O Key B-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG KFZD-SW-219-2-3 O We O thank O the O staff O and O postgraduate O students O of O Hunan O Provincial O Key O Laboratory O of O Animal O Nutritional O Physiology O and O Metabolic O Process O for O collecting O samples O and O technicians O from O Key O Laboratory O of O Agro-ecological O Processes O in O Subtropical O Region O for O providing O technical O assistance O The O study O was O supported O by O Key B-ORG Young I-ORG Medical I-ORG Talents I-ORG Project I-ORG in I-ORG Jiangsu I-ORG Province I-ORG QNRC2016142 O the B-ORG National I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81800283 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grant I-ORG BK20170207 O This O research O was O funded O by O Consejería B-ORG de I-ORG Salud I-ORG de I-ORG Andalucía I-ORG Junta I-ORG de I-ORG Andalucía I-ORG Spain I-ORG grant O PI-0055-2017 B-AWARD and O to O E.A O Consejería B-ORG de I-ORG Transformación I-ORG Económica I-ORG Industria I-ORG Conocimiento I-ORG y I-ORG Universidades I-ORG Junta I-ORG de I-ORG Andalucía I-ORG Spain I-ORG grant O PY20_01297 B-AWARD to O E.A O Fundación B-ORG Biomédica I-ORG Cádiz I-ORG Proyectos I-ORG INIBICA I-ORG 2019 I-ORG Cádiz I-ORG Spain I-ORG grant O LI19/I14NCO15 B-AWARD to O E.A O and O M.M.A.-E O and O Agencia B-ORG Estatal I-ORG de I-ORG Investigación I-ORG Ministerio I-ORG de I-ORG Ciencia I-ORG e I-ORG Innovación I-ORG Spain I-ORG grant O PID2020-113943RB-I00 B-AWARD to O E.A O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81403232 B-AWARD to O Y.Y.Q O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Nos.BK20171290 O and O BK2012686 O to O Y.Y.Q O Doctoral B-ORG Fund I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG No.20133250120003 O to O Y.Y.Q O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG for I-ORG Youths I-ORG No.BK20170516 O to O L.T O The O funder O had O no O implication O in O the O design O of O the O study O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O and O the O decision O to O submit O the O article O for O publication O This O project O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2016YFD0101802 O Henan B-ORG Major I-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG 181100110200 O and O Henan B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Outstanding I-ORG Youth I-ORG Funding I-ORG 174100510001 O of O China O This O work O was O financially O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 22122701 O 21731004 B-AWARD 21907050 B-AWARD 91953201 B-AWARD 21907044 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20202004 O and O the O Excellent B-ORG Research I-ORG Program I-ORG of I-ORG Nanjing I-ORG University I-ORG ZYJH004 O This O work O was O supported O by O Chinese B-ORG Society I-ORG of I-ORG Nephrology I-ORG No. O 1405046058 O Peking B-ORG University I-ORG Medical I-ORG seeds I-ORG for I-ORG Fund I-ORG interdisciplinary I-ORG Research I-ORG BMU20160584 O and O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Project O 30900681 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Planning B-ORG Funds I-ORG of I-ORG Scientific I-ORG and I-ORG Technological I-ORG of I-ORG the I-ORG Guangdong I-ORG Province I-ORG 2016B070701016 O the O GDAS B-ORG Special I-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG 2019GDASYL-0104017 O GDAS B-ORG Special I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG 2018GDASCX-0107 O and O the O National B-ORG Natural I-ORG Science I-ORG Fund I-ORG of I-ORG China I-ORG 31802279 O and O 31872499 B-AWARD The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O National B-ORG Science I-ORG Foundation O CNS-1136027 B-AWARD IIS-1149570 I-AWARD CNS-1544895 O National B-ORG Institute I-ORG on I-ORG Disability I-ORG and I-ORG Rehabilitation I-ORG Research O 90RE5017 B-AWARD Foundation B-ORG for I-ORG the I-ORG National I-ORG Institutes I-ORG of I-ORG Health O R01DC009834 B-AWARD This O study O was O supported O by O grants O from O the O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG CAPES O Computational O Biology O Programme O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo I-ORG FAPESP O Grant O No. O 2015/09202-0 O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq O MCTI/CNPq/Universal O Grant O No. O 457360/2014-3 B-AWARD and O Technology B-ORG Centre I-ORG for I-ORG Biorefining I-ORG and I-ORG Bioenergy I-ORG Project O No. O CC20090004 B-AWARD with O the O financial O support O of O Enterprise O Ireland O and O the O Irish O Industrial O Development O Agency O IDA O CAS O received O a O post-doctoral O fellowship O from O CAPES O Computational O Biology O Programme O Grant O No. O BEX B-AWARD 8083/15-0 O and O APS O received O research O fellowships O from O the O CNPq O This O work O was O supported O by O grant O 251831 O from O CONACyT B-ORG grants O IN210712 B-AWARD and O IN214715 B-AWARD from O PAPIIT B-ORG UNAM O and O grant O FESI-DIP-PAPCA-2014-24 B-AWARD PAPCA O FES I-ORG Iztacala O to O S. O Martínez-Calvillo O and O by O grants O 132312 B-AWARD and O 139898 B-AWARD from O CONACYT O to O R. O Manning-Cela O The O funders O had O no O role O in O the O design O of O the O study O data O collection O and O analysis O or O writing O of O the O manuscript O Lu O Zhang O received O founding O from O the O Finance B-ORG science I-ORG and I-ORG technology I-ORG project I-ORG of I-ORG Hainan I-ORG province I-ORG Hainan I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Program I-ORG No. O 418MS112;http://dost.hainan.gov.cn O Wenjin O Wu O received O founding O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFA0600304;http://www.most.gov.cn O Xinwu O Li O received O founding O from O the O International B-ORG Partnership I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG No. O 131C11KYSB20160061;http://www.bic.cas.cn O This O work O was O co-founded O by O these O three O projects O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2016YFC1200600 O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG China I-ORG and I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31672088 O and O the O Special B-ORG Fund I-ORG for I-ORG Scientific I-ORG Research I-ORG in I-ORG Environmental I-ORG Protection I-ORG Public I-ORG Interest I-ORG 201409061 O and O the O Common B-ORG Wealth I-ORG Special I-ORG Fund I-ORG for I-ORG the I-ORG Agricultural I-ORG Industry I-ORG No. O 201303019 B-AWARD and O the O International O Science O O Technology O Cooperation O Program O of O China O 2015DFG32300 O This O work O was O supported O by O the B-ORG research I-ORG project I-ORG in I-ORG No. I-ORG 6 I-ORG People’s I-ORG Hospital I-ORG jointly I-ORG established I-ORG scientific I-ORG research I-ORG fund I-ORG No. O 17-LY-03 B-AWARD The B-ORG research I-ORG Peiying I-ORG Talent I-ORG project I-ORG in I-ORG Shanghai I-ORG University I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG Affiliated I-ORG PUTUO I-ORG Hospital I-ORG No. O 2017210B B-AWARD 2017211B B-AWARD The B-ORG research I-ORG project I-ORG in I-ORG Shanghai I-ORG University I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG Affiliated I-ORG PUTUO I-ORG Hospital I-ORG No. O 2016315A B-AWARD This O study O is O supported O by O the O grants O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.2013RMFH012 O the B-ORG Province I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG No.2012FFA096 O the B-ORG Science I-ORG Foundation I-ORG of I-ORG Wuhan I-ORG NO. O 2015060101010049 O and O supported O by O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG NO. O 2042014kf0115 O This O study O was O supported O by O the O Basic O Science O Research O Program O Grant O 2020R1A2C1012109 B-AWARD through O the O National B-ORG Research I-ORG Foundation I-ORG NRF I-ORG of I-ORG Korea O This O work O was O also O supported O by O the O Korea O Medical O Device O Development O Fund O grant O funded O by O the O Korean B-ORG Government I-ORG the O Ministry O of O Science O and O ICT O the O Ministry O of O Trade O Industry O and O Energy O the O Ministry O of O Health O O Welfare O the O Ministry O of O Food O and O Drug O Safety O Grant O RS-2020-KD000142 B-AWARD and O the O Korea O Institute O of O Marine O Science O O Technology O Promotion O KIMST O funded O by O the O Ministry B-ORG of I-ORG Oceans I-ORG and I-ORG Fisheries I-ORG Korea I-ORG Grant O 20210660 B-AWARD Only O the O corresponding O author O TH O has O received O salary O from O the O various O foundations O Stiftelsen B-ORG Promobilia I-ORG 1)https://www.promobilia.se O Neuroförbundet B-ORG 4)https://neuro.se O Praktikertjänst B-ORG AB O 5)https://www.praktikertjanst.se/om-oss/forskning-och-utveckling O Personskadeförbundet B-ORG RTP I-ORG 3)https://rtp.se/kunskap/forskning O Norrbacka-Eugeniastiftelsen B-ORG 2)http://www.norrbacka-eugenia.se O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Forestry I-ORG Public I-ORG Welfare I-ORG Research I-ORG Project I-ORG of I-ORG China I-ORG Project O No. O 201404701 B-AWARD National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Project O No. O 31800599 B-AWARD and O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Project O No. O 2018M631211 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O U22A6005 B-AWARD 92150110 B-AWARD 92050112 B-AWARD and O 12104366 B-AWARD the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Nos O 2020YFA0211300 B-AWARD and O 2021YFA1201500 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG Central I-ORG Universities I-ORG No. O GK202201012 O JPM O was O funded O by O the O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG BBSRC O grant O number O BB/J01446X/1 B-AWARD through O the O EASTBIO O Doctoral O Training O Programme O SN O was O funded O by O an O ARC B-ORG Future I-ORG Fellowship I-ORG FT130100268 O CAW O was O funded O by O a O Natural B-ORG Environment I-ORG Research I-ORG Council I-ORG NERC O post-doctoral O research O fellowship O NE/I020245/1 O and O a O University O of O Edinburgh O Chancellor’s O fellowship O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 42177415 B-AWARD Zhenxing O Mao O 21806146 B-AWARD Wenqian O Huo O the O Scientific B-ORG and I-ORG Technological I-ORG Innovation I-ORG of I-ORG Colleges I-ORG and I-ORG Universities I-ORG in I-ORG Henan I-ORG Province I-ORG Talent I-ORG Support I-ORG Program I-ORG Grant O No. O 22HASTIT044 B-AWARD Zhenxing O Mao O the O Postdoctoral B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No O 2020T130604 B-AWARD Zhenxing O Mao O 2021M702934 B-AWARD Wenqian O Huo O the O Young B-ORG Backbone I-ORG Teachers I-ORG Program I-ORG of I-ORG Colleges I-ORG and I-ORG Universities I-ORG in I-ORG Henan I-ORG Province I-ORG Grant O No. O 2021GGJS015 B-AWARD Zhenxing O Mao O the O Science B-ORG and I-ORG Technique I-ORG Foundation I-ORG of I-ORG Henan I-ORG Province I-ORG Grant O No. O 212102310074 B-AWARD Wenqian O Huo O and O the O Excellent B-ORG Youth I-ORG Development I-ORG Foundation I-ORG of I-ORG Zhengzhou I-ORG University I-ORG Grant O No. O 2021ZDGGJS057 B-AWARD Wenqian O Huo O This O study O was O funded O by O the O a O Research O Grant O from O the O Sichuan B-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG I-ORG Sichuan I-ORG Provincial I-ORG People’s I-ORG Hospital I-ORG No.30305031017P O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Foundation I-ORG No.3035031263 O and O the O Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Office I-ORG No.3050410336 O The O funders O had O no O roles O in O the O study O design O in O collection O analysis O and O interpretation O of O data O in O the O writing O of O the O report O or O decision O to O submit O the O article O for O publication O This O work O was O supported O by O National B-ORG Science I-ORG Foundation I-ORG Cooperative O agreement O no. O DBI-0939454 B-AWARD BEACON O Center O National B-ORG Institutes I-ORG of I-ORG Health I-ORG grant O R01 B-AWARD GM088344 O and O Army B-ORG Research I-ORG Office I-ORG grant O W911NF-12-1-0390 B-AWARD This O work O was O funded O by O Progetto B-ORG Medio I-ORG Ateneo I-ORG 2020 I-ORG of I-ORG Sapienza I-ORG University I-ORG of I-ORG Rome I-ORG “Nanobio” I-ORG RM120172B7FEC4B8 B-AWARD and O in O part O by O ATTRACT O project O funded O by O the B-ORG EC I-ORG under O Grant O Agreement O 777222 B-AWARD Additional O funding O was O provided O by O project O 2020Y2JMP5 O ‘ANDROMeDa’ O CUP O I85F21004170005 B-AWARD funded O by O MUR B-ORG This O work O was O supported O by O the O grants O of O The O Scientific O and O Technology O Research O Council O of O Turkey O TUBITAK O Project O Number O IntenC-109S218 B-AWARD and O Scientific B-ORG Research I-ORG Projects I-ORG Coordination I-ORG Unit I-ORG of I-ORG Istanbul I-ORG University O Project O Number O ONAP-11021 B-AWARD Biobanking O support O was O given O by O Istanbul B-ORG Development I-ORG Agency I-ORG Project O Number O TR10/15/YNK/0093 B-AWARD OO, O EE O and O SAUI O had O been O fellows O of O TUBITAK-IntenC O project O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31672317 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0200900 O and O Competitive B-ORG Planning I-ORG Projects I-ORG of I-ORG Hubei I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG 2016jzxjh012 O The O work O was O supported O in O part O by O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Higher I-ORG Education I-ORG of I-ORG the I-ORG Russian I-ORG Federation O the O Russian B-ORG Foundation I-ORG for I-ORG Basic I-ORG Research O RFBR O grant O 17-54-30022 B-AWARD T.R.G O thanks O the O Russian B-ORG Science I-ORG Foundation I-ORG grant O Project O No. O 19-74-00152 B-AWARD for O the O support O of O the O part O of O the O work O on O fusion O pores O and O leaky O fusion O intermediates O Research O reported O in O this O publication O was O supported O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG via O the O National O Heart O Lung O And O Blood O Institute O with O the O multiple O principal O investigators O being O C. O Martin O and O T. O Church O R01 O HL102166 O the O NORC B-ORG Center I-ORG Grant I-ORG P30 B-AWARD DK072476 O entitled O “Nutritional O Programming O Environmental O and O Molecular O Interactions” O sponsored O by O NIDDK O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences O which O funds O the O Louisiana O Clinical O and O Translational O Science O Center O U54 O GM104940 O and O NIH O grant O F32 B-AWARD HL123242 I-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81603478 B-AWARD 81471848 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Chengdu I-ORG University I-ORG of I-ORG TCM I-ORG ZRQN1612 O Key B-ORG Project I-ORG of I-ORG Commission I-ORG of I-ORG Science I-ORG Technology I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2017sz0112 O and O Educational B-ORG Commission I-ORG of I-ORG Sichuan I-ORG Province I-ORG 17ZB0149 O This O study O is O supported O by O the O China B-ORG Scholarship I-ORG Council I-ORG No. O 201806910081 B-AWARD and O by O the O Dutch B-ORG Kidney I-ORG Foundation I-ORG CP1805 O USEQ O is O subsidized O by O the O University B-ORG Medical I-ORG Center I-ORG Utrecht I-ORG and I-ORG The I-ORG Netherlands I-ORG X-omics I-ORG Initiative I-ORG NWO O project O 184.034.019 B-AWARD This O research O was O funded O by O the O Hainan B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 320QN326 B-AWARD the O 2021 B-ORG Guangdong I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Strategy I-ORG Special I-ORG Fund I-ORG No. O 2021A101 B-AWARD and O 2021A05217 B-AWARD and O the O Basic B-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG of I-ORG China I-ORG No. O 2021A1515010538 B-AWARD and O the O Key B-ORG Laboratory I-ORG of I-ORG Food I-ORG Nutrition I-ORG and I-ORG Functional I-ORG Food I-ORG of I-ORG Hainan I-ORG Province I-ORG KF202007 O This O project O was O sponsored O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Chongqing I-ORG China I-ORG No. O Xm2017030 B-AWARD Science B-ORG Foundation I-ORG of I-ORG Southwest I-ORG Hospital I-ORG No. O SWH2017YBXM-27 B-AWARD and O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81773074 B-AWARD This O project O was O sponsored O by O the O Shanghai B-ORG Pujiang I-ORG Program I-ORG 17PJ1405000 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81772425 O 31771017 B-AWARD 31972924 O the O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG 16441908700 O the O Innovation B-ORG Research I-ORG Plan I-ORG supported I-ORG by I-ORG Shanghai I-ORG Municipal I-ORG Education I-ORG Commission I-ORG ZXWF082101 O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0110700 O Shanghai B-ORG Jiao I-ORG Tong I-ORG University I-ORG YG2016MS11 O JYYQ201516 B-AWARD YG2017MS09 B-AWARD and O the O Guangxi B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG Project I-ORG GK O AD17129017 O GK B-AWARD AD17195042 O The O funding O body O was O involved O in O the O design O of O the O study O collection O and O analysis O of O data O interpretation O of O data O the O writing O of O manuscript O polishing O of O English O manuscripts O with O mother O tongue O and O the O publication O charges O This O work O was O supported O by O the O Basic B-ORG and I-ORG Clinical I-ORG Research I-ORG Projects I-ORG of I-ORG Technology I-ORG Innovation I-ORG Development I-ORG Foundation I-ORG in I-ORG Tangdu I-ORG Hospital I-ORG NO.2016JCYJ001 O NO.2015LCYJ017 O the B-ORG Technology I-ORG Development I-ORG Foundation I-ORG of I-ORG the I-ORG Fourth I-ORG Military I-ORG Medical I-ORG University I-ORG NO.2016XD252 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81373118 O and O the B-ORG National I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 O Program O No.2012CB518905 O National B-ORG Outstanding I-ORG Youth I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31725022 O Key B-ORG Program I-ORG of I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31930084 O Molecular B-ORG Enzyme I-ORG and I-ORG Engineering I-ORG International I-ORG Cooperation I-ORG Base I-ORG of I-ORG South I-ORG China I-ORG University I-ORG of I-ORG Technology I-ORG 2017A050503001 O Special B-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG for I-ORG Leader I-ORG Project I-ORG in I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Development I-ORG of I-ORG New I-ORG Partial I-ORG Glycerin I-ORG Lipase I-ORG 2015TX01N207 O Marine B-ORG S&T I-ORG Fund I-ORG of I-ORG Shandong I-ORG Province I-ORG 2018SDKJ0302-2 O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0900503 O Funders O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the O Core B-ORG Programme I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Research I-ORG and I-ORG Innovation I-ORG of I-ORG Romania O project O No. O 19110202 B-AWARD 19110103 B-AWARD and O 23150104 B-AWARD Subprogram O 1.2—Institutional O performance—Projects I-ORG to I-ORG finance I-ORG excellence I-ORG in I-ORG RDI O contract O No. O 19PFE/30.12.2021 B-AWARD Ministry B-ORG of I-ORG Research I-ORG Innovation I-ORG Digitization I-ORG from I-ORG Romania I-ORG by I-ORG the I-ORG National I-ORG Plan I-ORG of I-ORG R I-ORG I-ORG D, O Project O No. O PN19110205/2019 B-AWARD and O by O UEFISCDI B-AWARD PN-III-P2-2.1-PED-2021-1980 B-AWARD Contract O No. O 719PED/2022 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 51805334 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG grant O numbers O 2016A040403043 B-AWARD and I-AWARD 2017A010102003 O the O major B-ORG project I-ORG for I-ORG industrial I-ORG technology I-ORG of I-ORG Guangzhou I-ORG City I-ORG grant O number O 201902010018 B-AWARD the O Fundamental O Research O Funds O for O the O Shenzhen O University O grant O number O 2018031 B-AWARD the O Youth O Projects O for O Creative O Talents O of O Educational O Commission O of O Guangdong O Province O grant O number O 2015KQNCX009 O This O work O was O supported O by: O 1) O CPRIT B-ORG Grant O RP140612 B-AWARD Ronald O DePinho O 2) O NIH B-ORG CDP I-ORG SPORE I-ORG Grant O P50CA12700107 B-AWARD F.L.M O 3) O Research B-ORG Scholar I-ORG Grant O RSG1514501CDD B-AWARD F.L.M O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O Scientific B-ORG Research I-ORG Fund I-ORG of I-ORG Hunan I-ORG Provincial I-ORG Education I-ORG Department I-ORG 16B042 O Doctor B-ORG Scientific I-ORG Research I-ORG Fund I-ORG of I-ORG Hengyang I-ORG Normal I-ORG University I-ORG 14B26 O Scientific B-ORG Research I-ORG Fund I-ORG of I-ORG China I-ORG Education I-ORG Department I-ORG grant O 16JDSZ2002 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O the O Zhejiang B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O No. O LQ19H160013 B-AWARD and O the O Zhejiang B-ORG Medical I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG Grant O No. O 2019323421 B-AWARD and O the O Hangzhou B-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG Grant O no. O 2017A26 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O 21827812 B-AWARD 31571005 B-AWARD 81871450 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Chongqing O cstc2018jcyjAX0389 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities O 2019CDYGYB016 B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFC1200500 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81601781 B-AWARD and O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O KLF201012 B-AWARD This O study O was O financially O supported O by O the O Second B-ORG Tibetan I-ORG Plateau I-ORG Scientific I-ORG Expedition I-ORG and I-ORG Research I-ORG Program I-ORG STEP O 2019QZKK1003 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 41877047 B-AWARD 2022 B-ORG Undergraduate I-ORG Teaching I-ORG and I-ORG Research I-ORG Reform I-ORG Project I-ORG of I-ORG Liaoning I-ORG Province O “Research O on O the O construction O of O the O course O teaching O and O practice O system O of O “Pollution O Site O Remediation O Technology’ O based O on O OBE O concept” O 2022-36-10 O and O 2021 B-ORG Intercollegiate I-ORG Cooperation I-ORG Project I-ORG of I-ORG Liaoning I-ORG Ordinary I-ORG Undergraduate I-ORG Colleges I-ORG resource O sharing O 2021-49 O This O work O was O funded O byAlzheimer's O Association10.13039/100000957grantsAARF‐D‐619473andAARF‐D‐619473‐RAPID;National O Institute I-ORG of I-ORG Neurological I-ORG Disorders I-ORG and I-ORG Stroke10.13039/100000065grantK23‐NS114167;National O Institute I-ORG on I-ORG Aging10.13039/100000049grantsP01‐AG066597,P30‐AG072979,R01‐AG054519 O andU19‐AG062418;University O of O Pennsylvania O Institute O on O Aging O This O work O was O sponsored O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O L2224042 B-AWARD T2293731 B-AWARD 62121003 B-AWARD 61960206012 B-AWARD 62171434 B-AWARD 61971400 B-AWARD 61975206 B-AWARD and O 61973292 B-AWARD the O Frontier B-ORG Interdisciplinary I-ORG Project I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG No. O XK2022XXC003 B-AWARD the O Scientific B-ORG Instrument I-ORG Developing I-ORG Project I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG No. O GJJSTD20210004 B-AWARD the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG No. O 2022YFB3205602 B-AWARD 2022YFC2402501 B-AWARD and O the O major B-ORG program I-ORG of I-ORG scientific I-ORG and I-ORG technical I-ORG innovation I-ORG 2030 I-ORG No. O 2021ZD0201603 B-AWARD This O study O is O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 31371289 B-AWARD to O JG O and O QL O the O Major B-ORG Disease I-ORG Research I-ORG Projects I-ORG of I-ORG Xiamen O China O 3502Z20149030 O to O YLZ O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province O China O Grant O No. O 2018J01054 B-AWARD to O YZ) O and O the O Education B-ORG and I-ORG Research I-ORG Foundation I-ORG for I-ORG Young I-ORG Scholars I-ORG of I-ORG Education I-ORG department I-ORG of I-ORG Fujian I-ORG Province I-ORG Grant O No. O JAT170004 B-AWARD to O YZ O This O study O was O supported O by O grants O from O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82271371 O and O 82260367 B-AWARD Health B-ORG Appropriate I-ORG Technology I-ORG Development I-ORG and I-ORG Application I-ORG Project I-ORG S2021107 O and O the O Clinical B-ORG Research I-ORG “Climbing” I-ORG Program I-ORG of I-ORG the I-ORG First I-ORG Affiliated I-ORG Hospital I-ORG of I-ORG Guangxi I-ORG Medical I-ORG University I-ORG YYZS2021002 O The O work O was O financially O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82174083 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2022NSFSC1735 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG ZYN2022094 O This O research O was O funded O by: O the O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG NIHR O project O reference O 17/63/82 B-AWARD using O UK O aid O from O the O UK O Government O to O support O global O health O research O JH O O MJK O the O Engineering B-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG EPSRC O grant O reference O EP/S022244/1 B-AWARD MJK O Health B-ORG Data I-ORG Research I-ORG UK, O which O receives O its O funding O from O HDR O UK O Ltd O NIWA1 O MJK O The O views O expressed O in O this O publication O are O those O of O the O authors O and O not O necessarily O those O of O the O any O of O the O funders O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Jinan B-ORG Youth I-ORG Science I-ORG and I-ORG Technology I-ORG Star I-ORG Program I-ORG No. O 201406013 O the B-ORG Key I-ORG R I-ORG I-ORG D I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG No. O 2015GSF121033 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG of I-ORG China I-ORG ZR2016HL27 O ZR2017LH066 O and O Science O O Technology O development O project O of O Traditional O Chinese O Medicine O of O Shandong O Province O 2017-057 O This O study O was O supported O by O grants O from O Shenzhen B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Committee O nos O JCYJ20180209163904869 B-AWARD Shenzhen B-ORG People’s I-ORG Hospital I-ORG nos O SYJY201802 B-AWARD Ningbo B-ORG Municipal I-ORG Natural I-ORG Science I-ORG Grant I-ORG nos.2016A610130 O 2018A610231 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O in O part O by O grants O from O the O Japanese B-ORG Ministry I-ORG of I-ORG Education I-ORG Culture I-ORG Sports I-ORG Science I-ORG and I-ORG Technology I-ORG 26293198 O 17H04182 O the O Intractable B-ORG Respiratory I-ORG Diseases I-ORG and I-ORG Pulmonary I-ORG Hypertension I-ORG Research I-ORG Group I-ORG the I-ORG Ministry I-ORG of I-ORG Health I-ORG Labor I-ORG and I-ORG Welfare I-ORG in I-ORG Japan I-ORG H29-intractable O diseases-general-027 O the O Research B-ORG Foundation I-ORG for I-ORG Healthy I-ORG Aging I-ORG Health I-ORG Labour I-ORG and I-ORG Welfare I-ORG Sciences I-ORG Research I-ORG Grants I-ORG Research I-ORG on I-ORG Region I-ORG Medical I-ORG from I-ORG the I-ORG Ministry I-ORG of I-ORG Health I-ORG Labor I-ORG and I-ORG Welfare I-ORG of I-ORG Japan I-ORG H28-iryo-ippan-016 O H30-iryo-ippan-009 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O financial O grants O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No.2016YFC0901504 O and O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG No.15DZ1208002 O David O Beeson O was O supported O by O MRC B-ORG Programme I-ORG Grant I-ORG MR/M006824/1 B-AWARD The O remaining O authors O have O no O conflicts O of O interest O The O authors O received O support O from O National B-ORG High-tech I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2013AA01A606 O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2014CB744600 O Key B-ORG Research I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG CAS I-ORG KJZD-EWL04 O and O CAS B-ORG Strategic I-ORG Priority I-ORG Research I-ORG Program I-ORG XDA06030800 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 51502257 B-AWARD 61574122 B-AWARD 21373107 B-AWARD and O 61704146 B-AWARD the O Innovative B-ORG Research I-ORG Team I-ORG in I-ORG Science I-ORG and I-ORG Technology I-ORG in I-ORG University I-ORG of I-ORG Henan I-ORG Province I-ORG No. O 13IRTSTHN018 B-AWARD and O the O program B-ORG for I-ORG Science I-ORG I-ORG Technology I-ORG Innovation I-ORG Talents I-ORG in I-ORG Universities I-ORG of I-ORG Henan I-ORG Province I-ORG No. O 15HASTIT018 B-AWARD This O research O was O funded O and O supported O by O the O Key B-ORG Technologies I-ORG Research I-ORG and I-ORG Development I-ORG Program O grant O number O 2018YFE0106100 B-AWARD the O National B-ORG Social I-ORG Science I-ORG Fund I-ORG of I-ORG China O grant O number O 19BSH060 B-AWARD Zhejiang O Provincial O Key O R&D O Program O grant O number O 2019C02031 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 51878592 B-AWARD This O work O was O supported O by O the O NSTDA O Research B-AWARD Chair I-AWARD grant I-AWARD from O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Agency I-ORG Thailand O NC O the O Senior B-AWARD Research I-AWARD Scholar I-AWARD grant I-AWARD from O the O National B-ORG Research I-ORG Council I-ORG of I-ORG Thailand I-ORG SCC O and O the O Chiang B-ORG Mai I-ORG University I-ORG Center B-AWARD of I-AWARD Excellence I-AWARD Award I-AWARD NC O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31301968 B-AWARD the O Program B-ORG for I-ORG Doctoral I-ORG Scientific I-ORG Research I-ORG Start-up I-ORG Funds I-ORG of I-ORG Guangdong I-ORG Polytechnic I-ORG of I-ORG Science I-ORG and I-ORG Trade I-ORG GDKM2022-94 O and O the O Horizontal B-ORG Project I-ORG of I-ORG Guangdong I-ORG Polytechnic I-ORG of I-ORG Science I-ORG and I-ORG Trade I-ORG GDKM-2022-A-49 O This O work O was O supported O by O the O Agency B-ORG for I-ORG Healthcare I-ORG Research I-ORG and I-ORG Quality-funded O UT O Southwestern O Center O for O Patient-Centered O Outcomes O Research O R24HS022418 O Dr. O Makam O is O funded O by O the O National B-ORG Institute I-ORG on I-ORG Aging I-ORG K23AG052603 O Dr. O Nguyen O is O funded O by O the O National B-ORG Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute I-ORG K23HL133441 O The O study O sponsors O had O no O role O in O the O design O and O conduct O of O the O study O collection O management O analysis O and O interpretation O of O the O data O and O preparation O review O or O approval O of O the O manuscript O This O study O was O supported O by O the B-ORG Program I-ORG for I-ORG Zhejiang I-ORG Leading I-ORG Team I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG No. O 2011R50021 B-AWARD the B-ORG Zhejiang I-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O LQ16H260002 B-AWARD and O the B-ORG Science I-ORG Program I-ORG for I-ORG Hangzhou I-ORG Social I-ORG Development I-ORG 20160533B02 O Jin-liang O Chen O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20191207 O Jin-nan O Wu: O Postgraduate B-ORG Research I-ORG I-ORG Practice I-ORG Innovation I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG SJCX19_0873 O Dong-mei O Zhang O the B-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG Health I-ORG Commission I-ORG of I-ORG Jiangsu I-ORG Province I-ORG H2018035 O the B-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG “333 I-ORG Project” I-ORG in I-ORG Jiangsu I-ORG Province I-ORG BRA2018224 O Jian-rong O Chen O the B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Nantong I-ORG City I-ORG Grant O No. O HS2018002 B-AWARD Jin-liang O Chen O Conceptualization O Methodology O Software O Investigation O Jin-nan O Wu: O Formal O analysis O Data O curation O Software O Investigation O Writing-Original O draft O preparation O Xue-dong O Lv: O Visualization O Investigation O Qi-chang O Yang O Supervision O Dong-mei O Zhang O Software O Validation O Jian-rong O Chen O Project O administration O Writing-Reviewing O and O Editing O The O authors O thank O all O the O staff O members O in O our O institution O This O research O was O funded O by O São B-ORG Paulo I-ORG Research I-ORG Foundation I-ORG FAPESP O Brazil O to O Clélia O Akiko O Hiruma-Lima O grant O number O 2018/09873-0 B-AWARD Felipe O Lima O Dario O grant O number O 2020/07384-2 B-AWARD and O Maycon O Tavares O Emilio-Silva O grant O number O 2020/15225-1 B-AWARD Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq O Brazil O to O Clélia O Akiko O Hiruma-Lima O grant O number O 311957/2020-0 B-AWARD and O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG CAPES O Brazil O to O Rie O Ohara O grant O number O 88882.183586/2018-01 B-AWARD Renata O Assunção O grant O number O 88887.669273/2022-00 B-AWARD Vinicius O Peixoto O Rodrigues O grant O number O 88882.183585/2018-01 B-AWARD Gabriela O Bueno O grant O number O 88887.696106/2022-00 B-AWARD Priscila O Romano O Raimundo O grant O number O 88887.669269/2022-00 B-AWARD This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Grant O Numbers O 2018YFA0900300 B-AWARD and O 2018YFA0901400 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Numbers O 31700044 B-AWARD and O 31870044 B-AWARD and O Key B-ORG R&D I-ORG Plan I-ORG of I-ORG Shandong I-ORG Province I-ORG Grant O Number O 2017CXGC1103 B-AWARD This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51779005 O 51769015 B-AWARD 51779005 O 51879128 O the O Jiangxi B-ORG Provincial I-ORG Technology I-ORG Department I-ORG 20142BAB213024 O 20142BBF60012 O 20171ACB21050 O 20182BCB22013 B-AWARD and O the O Nanchang B-ORG Institute I-ORG of I-ORG Technology I-ORG YJSCX20180003 O TFdS O has O received O funding O from O the O European O Union O Horizon B-ORG 2020 I-ORG research O and O innovation O programme O under O the O Marie O Sklodowska-Curie O grant O agreement O N722427 O CGA O is O a O P-FIS B-AWARD fellow O Instituto O de I-ORG Salud I-ORG Carlos I-ORG III O This O study O was O partially O supported O by O the O Comunidad B-ORG de I-ORG Madrid I-ORG S2017/BMD-3867 O RENIM-CM O and O cofunded O with O European O structural O and O investment O funds O The O CNIC O is O supported O by O the O Instituto O de O Salud O Carlos O III O ISCIII O the O Ministerio O de O Ciencia O Innovación O y O Universidades O MCNU O and O the O Pro O CNIC O Foundation O and O is O a O Severo O Ochoa O Center O of O Excellence O SEV-2015-0505 O This O work O was O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG 15ZR1436700 O and O Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Talents I-ORG Project I-ORG 14XD1425100 O and O the O Scientific B-ORG Research I-ORG Project I-ORG in I-ORG Public I-ORG Agricultural I-ORG Industry I-ORG 201403032 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O is O support O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Project O Nos O 51502074 B-AWARD 61604051 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG Project O No. O F2017202052 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Tianjin I-ORG City I-ORG Project O No. O 16JCYBJC16200 B-AWARD Program B-ORG for I-ORG Top I-ORG 100 I-ORG Innovative I-ORG Talents I-ORG in I-ORG Colleges I-ORG and I-ORG Universities I-ORG of I-ORG Hebei I-ORG Province I-ORG Project O No. O SLRC2017032 B-AWARD and O Program B-ORG for I-ORG 100-Talent-Plan I-ORG of I-ORG Hebei I-ORG Province I-ORG Project O No. O E2016100010 B-AWARD This O research O was O supported O by O Outstanding B-ORG Youth I-ORG Scientific I-ORG Innovation I-ORG Team I-ORG Project I-ORG for I-ORG the I-ORG Universities I-ORG of I-ORG Hubei I-ORG Province I-ORG T201213 O New B-ORG Century I-ORG Excellent I-ORG Talents I-ORG Project I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG NCET-13-0781 O and O Hubei B-ORG Major I-ORG Projects I-ORG of I-ORG Technical I-ORG Innovation I-ORG 2016ACA148 O This O study O was O financially O supported O by O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG China I-ORG RZ, O WKL O 2017ZX10103011003 O 2018ZX10102001 B-AWARD https://www.most.gov.cn O Guangzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG key I-ORG projects I-ORG RZ) O 201803040004 O 201704020225 O http://www.gzsi.gov.cn O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG of I-ORG China I-ORG QL) O 2016A020215001 O http://pro.gdstc.gov.cn O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG of I-ORG China I-ORG QL) O 2018A030310401 O http://pro.gdstc.gov.cn O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG WKL O 31500143 O http://www.nsfc.gov.cn O This O research O was O funded O by O the O Beijing B-ORG Municipal I-ORG Natural I-ORG Science I-ORG Foundation I-ORG grant O number O 6212033 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG grant O number O 2021YFD1200804 B-AWARD and O the O Special B-ORG Scientific I-ORG Research I-ORG Funds I-ORG for I-ORG Central I-ORG Non-profit I-ORG Institutes I-ORG Chinese I-ORG Academy I-ORG of I-ORG Fishery I-ORG Sciences I-ORG grant O number O 2020TD24 B-AWARD This O project O was O supported O by O a B-ORG grant I-ORG from I-ORG the I-ORG Basic I-ORG Science I-ORG Research I-ORG Program I-ORG through I-ORG the I-ORG National I-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG funded I-ORG by I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG 2021R1F1A1048113 O to O T.-J.S O This O work O was O supported O by O an B-ORG Institute I-ORG of I-ORG Information I-ORG I-ORG Communications I-ORG Technology I-ORG Planning I-ORG I-ORG Evaluation I-ORG IITP I-ORG grant I-ORG funded I-ORG by I-ORG the I-ORG Korea I-ORG government I-ORG MSIT O No. O 2022-0-00621 B-AWARD to O T.-J.S O Development O of O artificial O intelligence O technology O that O provides O dialog-based O multi-modal O explainability O This O research O was O supported O by O a B-ORG grant I-ORG of I-ORG the I-ORG Korea I-ORG Health I-ORG Technology I-ORG R I-ORG I-ORG D I-ORG Project I-ORG through I-ORG the I-ORG Korea I-ORG Health I-ORG Industry I-ORG Development I-ORG Institute I-ORG KHIDI I-ORG funded I-ORG by I-ORG the I-ORG Ministry I-ORG of I-ORG Health I-ORG I-ORG Welfare I-ORG Republic I-ORG of I-ORG Korea I-ORG grant O number O HI22C073600 B-AWARD to O T.-J.S O This O study O was O supported O by O Medical B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O China O No. O A2015289 B-AWARD to O QHC O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81502119 B-AWARD to O FL O and O No. O 81172342 B-AWARD to O LX O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2015A030310109 B-AWARD to O FL O This O work O was O supported O by O the O Guangxi B-ORG Science I-ORG and I-ORG Technology I-ORG Base I-ORG and I-ORG Talent I-ORG Project I-ORG 2021AC18026 O Guangxi B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2020JJB170048 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 62274045 O 62004050 B-AWARD 52165056 B-AWARD Guangxi B-ORG Key I-ORG Laboratory I-ORG of I-ORG Manufacturing I-ORG Systems I-ORG and I-ORG Advanced I-ORG Manufacturing I-ORG Technology I-ORG 17-259-05-018Z O Guangxi B-ORG Young I-ORG Teacher I-ORG Education I-ORG Project I-ORG 2020KY05020 O the O Innovation B-ORG Project I-ORG of I-ORG Guangxi I-ORG Graduate I-ORG Education I-ORG YCSW2022287 O YCBZ2022114 B-AWARD YCBZ2021073 B-AWARD the O GUET B-ORG Excellent I-ORG Graduate I-ORG Thesis I-ORG Program I-ORG 19YJPYBS02 O the O Innovation B-ORG Project I-ORG of I-ORG GUET I-ORG Graduate I-ORG Education I-ORG 2020YCXS010 O 2021YCXS001 B-AWARD This O work O is O partially O supported O by O National O Science O Foundation O of O China O under O Grant O No. O 61873085 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG under O Grant O No. O BK20171198 B-AWARD The B-ORG University I-ORG Graduate I-ORG Research I-ORG and I-ORG Innovation I-ORG Projects I-ORG of I-ORG Jiangsu I-ORG Province I-ORG under O Grant O No. O KYCX17_0540 B-AWARD The B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG under O Grant O No. O 2017B679X14 B-AWARD 2017B20014 I-AWARD This O study O was O financially O supported O by O the O Beijing B-ORG Nature I-ORG Science I-ORG Foundation I-ORG 7192227 O to O establish O the O method O for O automated O superimposition O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51972005 O 51672009 B-AWARD and O the O Research B-ORG Foundation I-ORG of I-ORG Peking I-ORG University I-ORG School I-ORG and I-ORG Hospital I-ORG of I-ORG Stomatology I-ORG PKUSS20190115 O for O sample O collection O and O data O acquisition O 1.Elite O Youth I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences O Grant O number:n/a.http://www.caas.net.cn/kjcxgczl/zytz/237653.shtml2 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31400067).http://www.nsfc.gov.cn/3 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG Central I-ORG Public I-ORG Interest I-ORG Institutes I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG 2015ZL045).http://www.caas.cn4 O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 863 I-ORG program I-ORG no. O 2012AA022208),http://www.863.gov.cn/5 B-AWARD China B-ORG Modern I-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-42),http://www.moa.gov.cn O This O work O was O sponsored O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 31672689 B-AWARD I-AWARD 31372558 O The B-ORG National I-ORG Key I-ORG Growth I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG College I-ORG No. O 2014GKXM043 B-AWARD and O The B-ORG Key I-ORG Innovation I-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Guangdong I-ORG Province I-ORG College I-ORG No. O 2012CXZD0025 B-AWARD This O research O was O funded O by O AMINOVITA B-ORG S.L I-ORG PRJ201803388 O Additional O financial O support O was O provided O by O Junta B-ORG de I-ORG Andalucía I-ORG grant O numbers O 2017/CTS-657 B-AWARD 2019/CTS-657 B-AWARD 2021/CTS-657 B-AWARD and O the O University O of O Seville O through O the O “V O Plan O Propio O de O Investigación O y O Transferencia O PPI2015-II.2)” O and O the O “VI O Plan I-ORG Propio I-ORG de I-ORG Investigación I-ORG y I-ORG Transferencia” O grant O numbers O VIPPIT-2019-I.5 B-AWARD VIPPIT-2020-I.5 B-AWARD VIPPIT-2021-I.5 B-AWARD and O VIPPIT-2020-II.3 B-AWARD This O study O was O supported O by O the O grants O from O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC1200500 O 2017YFC1201000 B-AWARD the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81371845 O 81420108024 B-AWARD 81528013 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2014A030312016 O 2016A020251001 B-AWARD the B-ORG Guangzhou B-ORG Synergy I-ORG Innovation I-ORG Key I-ORG Program I-ORG for I-ORG Health I-ORG 201508020263 O 201605030010 B-AWARD and O the B-ORG National I-ORG Institutes I-ORG of I-ORG Health I-ORG USA I-ORG R01 O AI083202 I-AWARD and O D43 B-AWARD TW009527 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O U1604172 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Henan I-ORG Province I-ORG co-established I-ORG by I-ORG the I-ORG province I-ORG and I-ORG the I-ORG ministry I-ORG No. O 201701002 B-AWARD and O the B-ORG Science I-ORG and I-ORG Technology I-ORG Colleges I-ORG Innovation I-ORG Team I-ORG Support I-ORG Program I-ORG of I-ORG Henan I-ORG Province I-ORG No. O 18IRTSTHN024 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31801856 O the O Hebei B-ORG Province I-ORG Higher I-ORG Education I-ORG Youth I-ORG Talents I-ORG Program I-ORG BJ2018016 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG C2017209103 O and O Hebei B-ORG Province I-ORG Postgraduate I-ORG Demonstration I-ORG Course-Genomics I-ORG KCJSX2018053 O This O study O was O financially O supported O by O grants O from O the O 948 B-ORG Program I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Agriculture I-ORG of I-ORG China I-ORG 2012-G1[4 O the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2013AA102501 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 31272432 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 82002323 B-AWARD the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG grant O number O 2020YFC2004900 B-AWARD and O the O Military B-ORG Medical I-ORG Science I-ORG and I-ORG Technology I-ORG Youth I-ORG Development I-ORG Programme I-ORG grant O number O 21QNPY110 B-AWARD This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC I-ORG Grant O No. O 31500310 B-AWARD the O Scientific B-ORG Research I-ORG Foundation I-ORG of I-ORG the I-ORG Higher I-ORG Education I-ORG Institutions I-ORG of I-ORG Guangxi I-ORG Province I-ORG China I-ORG Grant O No. O KY2015ZD016 B-AWARD Key B-ORG Laboratory I-ORG of I-ORG Ecology I-ORG of I-ORG Rare I-ORG and I-ORG Endangered I-ORG Species I-ORG and I-ORG Environmental I-ORG Protection I-ORG Guangxi I-ORG Normal I-ORG University I-ORG Ministry I-ORG of I-ORG Education I-ORG China I-ORG Grant O No. O ERESEP2017Z02 B-AWARD Guangxi B-ORG Key I-ORG Laboratory I-ORG of I-ORG Rare I-ORG and I-ORG Endangered I-ORG Animal I-ORG Ecology I-ORG Guangxi I-ORG Normal I-ORG University I-ORG Grant O No. O GKN.15-A-01-09 B-AWARD and O the O Ecological B-ORG Doctoral I-ORG Program I-ORG Construction I-ORG of I-ORG Guangxi I-ORG Normal I-ORG University I-ORG Grant O No. O EDPC B-AWARD 2018003 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Hungarian B-ORG National I-ORG Research I-ORG Development I-ORG and I-ORG Innovation I-ORG Office I-ORG NKFIH O FK-128133 O to O R.P O K-124670 B-AWARD to O P.T O and O K-125340 B-AWARD to O A.T O Hungarian B-ORG Academy I-ORG of I-ORG Sciences I-ORG LP2014‐18 O to O Z.D O PREMIUM-2017-48 O to O R.P O VUB B-ORG SRP51 O 2019–24 O to O P.T O New B-ORG National I-ORG Excellence I-ORG Programme I-ORG UNKP O ELTE/12653/314(2018 O to O M.K O National B-ORG Research I-ORG Council I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG NST O of O Korea O NTM2231611 O to O P.T O European B-ORG Union's I-ORG Horizon I-ORG 2020 I-ORG research I-ORG and I-ORG innovation I-ORG programme I-ORG 778247 O IDPfun I-AWARD to O S.T O P.T O and O Z.D O Funding O for O open O access O charge O Hungarian O Academy O of O Sciences O W.D O E.W O C.T O and O W.-T.C O are O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 32171244 B-AWARD 12234019 B-AWARD 21721003 B-AWARD Youth B-ORG Innovation I-ORG Promotion I-ORG Association I-ORG CAS I-ORG Grant O No. O 2020231 B-AWARD and O Jilin B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Plan I-ORG Grant O No. O 20200301009RQ B-AWARD This O study O was O financed O in O part O by O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG CAPES—Finance O code O 001 B-AWARD and O by O the O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG do I-ORG Amazonas I-ORG FAPEAM O Pró-Estado O Program-#002/2008 O 007/2018 B-AWARD and O 005/2019 B-AWARD We O also O would O like O to O thank O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq O for O the O productivity O scholarships O grants O provided O to O W.M.M O No. O 309207/2020-7 B-AWARD to O H.H.F.K O No. O 305942/2020-4 B-AWARD and O to O G.C.M O No O 315156/2021-0 B-AWARD The O author O H.H.F.K O also O acknowledges O FAPEAM O for O the O PRODOC O project O call O 003/2022 B-AWARD V.M O and O V.S O were O supported O by O AFM B-ORG Telethon O grant O number O 23531 B-AWARD and O 24247 B-AWARD respectively O M.S O was O supported O by O AFM O Telethon O fellowship O number O 23704 B-AWARD G.C O was O supported O by O Sapienza B-ORG University I-ORG of I-ORG Rome O grant O number O 000315_22 B-AWARD T.A.M O was O supported O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH O by O grants O HL116848 B-AWARD HL147558 B-AWARD DK119594 B-AWARD HL127240 B-AWARD and O HL150225 B-AWARD The O authors O are O indebted O to O gratefully O acknowledge O Natural B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81870145 O 82200234 B-AWARD Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangzhou I-ORG 201904010481 O Guangdong O Basic O and O Applied O Basic O Research O Foundation O 2023A1515030045 O and O President B-ORG Foundation I-ORG of I-ORG Nanfang I-ORG Hospital I-ORG Southern I-ORG Medical I-ORG University I-ORG 2022B008 O This O work O was O supported O by O the O Special B-ORG Funds I-ORG for I-ORG Basic I-ORG Science I-ORG Research I-ORG of I-ORG Central I-ORG Public I-ORG Research I-ORG Institutes I-ORG CAFYBB2016SY010 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31770578 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG LY17C030002 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82174120 O 81970991 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG No. O 21ZR1463100 B-AWARD and O the O Program B-ORG of I-ORG Shanghai I-ORG Academic I-ORG Research I-ORG Leader I-ORG 22XD1423400 O This O research O was O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2016YFD0500507 B-AWARD to O JMY O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG South-Central I-ORG University I-ORG for I-ORG Nationalities I-ORG Grant O No. O CZY19020 B-AWARD to O MFY O the O Open B-ORG Project I-ORG of I-ORG Hubei I-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG for I-ORG Protection I-ORG and I-ORG Application I-ORG of I-ORG Special I-ORG Plant I-ORG Germplasm I-ORG in I-ORG Wuling I-ORG Area I-ORG of I-ORG China I-ORG WLSP201903 O to O LM O and O fund B-ORG for I-ORG Key I-ORG laboratory I-ORG Construction I-ORG of I-ORG Hubei I-ORG Province I-ORG Grant O No. O 2018BFC360 B-AWARD to O MFY O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O CIISA—Centro O de O Investigação O Interdisciplinar O em O Sanidade O Animal O Faculdade O de O Medicina O Veterinária O Universidade O de O Lisboa O Lisboa O Portugal O Project O UIDB/00276/2020 B-AWARD funded O by O FCT B-ORG LA/P/0059/2020—AL4AnimalS O JM O acknowledges O funding O from O the O Fundação B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG Tecnologia I-ORG Portugal I-ORG grant O refs O SFRH/BD/149758/2019 B-AWARD and O ref O UIDB/00006/2020 B-AWARD NS O acknowledges O funding O from O the O Fundação O para O a O Ciência O e O Tecnologia O Portugal O ref O UIDB/00006/2020 O and O the O Polish B-ORG National I-ORG Agency I-ORG for I-ORG Academic I-ORG Exchange I-ORG Poland I-ORG ref O PPN/ULM/2020/1/00069/U/00001 B-AWARD Russian B-ORG Foundation I-ORG for I-ORG Basic I-ORG Research I-ORG 20-34-70143 O to O A.V.A O Russian B-ORG Science I-ORG Foundation I-ORG 22-15-00129 O to O A.M.V O molecular O modeling O 22-14-00235 B-AWARD to O T.L.A O cytotoxicity O assays O and O sncRNA O imaging O in O the O macrophage O infection O model O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Higher I-ORG Education I-ORG of I-ORG the I-ORG Russian I-ORG Federation I-ORG 075-15-2019-1669 O to O A.M.V O binding O assay O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31372378 B-AWARD the O Graduate B-ORG Student I-ORG Innovation I-ORG Program I-ORG of I-ORG Jiangsu I-ORG province I-ORG KYLX15-1116 O and O the O Graduate B-ORG Student I-ORG Innovation I-ORG Program I-ORG of I-ORG Jiangsu I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG in O 2014 O YCX14B-03 O This O work O was O funded O by O Project O PID2019-109476RB-C21 B-AWARD BIOALGRI O Spanish O Ministry O of O Science O Madrid O Spain O Proyecto B-ORG Intramural I-ORG Especial I-ORG CSIC I-ORG Ref O 202280I032 B-AWARD N.N O was O funded O by O the O Agustín O de O Betancourt O Programme O Cabildo O de O Tenerife O TFinnova O Programme O supported O by O MEDI O and O FDCAN O funds O I.A.J O TESIS2020010063 O acknowledges O funding O from O Agencia B-ORG Canaria I-ORG de I-ORG Investigación I-ORG Innovación I-ORG y I-ORG Sociedad I-ORG de I-ORG la I-ORG Información I-ORG ACIISI O cofunded O by O Fondo O Social O Europeo O FSE O y O FEDER O Consorcio O Centro B-ORG de I-ORG Investigación I-ORG Biomédica I-ORG en I-ORG Red I-ORG CIBER O de O Enfermedades O Infecciosas O Instituto O de O Salud O Carlos O III O Spain O CB21/13/00100 O Ministerio O de O Sanidad O Gobierno O de O España O and O funded O by O the O Cabildo O de O Tenerife O Tenerife O innova O Marco O Estratégico O de O Desarrollo O Insular O MEDI O and O Fondo O de O Desarrollo O de O Canarias O FDCAN O and O Ministerio O de O Sanidad O Consumo O e O Igualdad O This O work O was O supported O by: O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG 2021B1515140041 O High-level B-ORG Talents I-ORG Project I-ORG of I-ORG Dongguan I-ORG University I-ORG of I-ORG Technology I-ORG KCYCXPT2017007 O Guangdong B-ORG Innovation I-ORG Research I-ORG Team I-ORG for I-ORG Higher I-ORG Education I-ORG 2017KCXTD030 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81370326 O 81641005 B-AWARD Beijing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG Z181100001718200 O National B-ORG Precision I-ORG Medical I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0905602 O and O Beijing B-ORG Municipal I-ORG Natural I-ORG Science I-ORG Foundation I-ORG 7202168 O We O are O grateful O for O financial O support O from O the O Beijing B-ORG Agricultural I-ORG Forestry I-ORG Academy I-ORG Youth I-ORG Fund I-ORG No. O QNJJ201630 B-AWARD the O Special O Projects O of O Construction O of O Science O and O Technology O Innovation O Ability O of O Beijing O Academy O of O Agriculture O and O Forestry O Sciences O Np. O KJCX20170420 B-AWARD the O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG L182031 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 21806013 B-AWARD 31801634 B-AWARD 21806014 B-AWARD the O International O Cooperation O Fund O of O Beijing O Agricultural O Forestry O Academy O No. O GJHZ2018-05 B-AWARD the O Project O of O Beijing O Science O and O Technology O No. O Z171100001517017 B-AWARD the O Project O of O Beijing O Excellent O Talents O No. O 2017000020060G127 B-AWARD the O Open O Project O of O Risk O Assessment O Laboratory O for O Agro-Products O of O the O Ministry O of O Agriculture O No. O KFKT201707 B-AWARD We O also O thank O David O MacDonald O MSc O for O editing O the O English O text O of O a O draft O of O this O manuscript O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31870979 B-AWARD funded O by O Weiming O Zeng O No. O 61906117 B-AWARD funded O by O Yuhu O Shi O Shanghai B-ORG Sailing I-ORG Program I-ORG Grant O No. O 19YF1419000 B-AWARD funded O by O Yuhu O Shi O and O the B-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Projects I-ORG of I-ORG the I-ORG Shanghai I-ORG Science I-ORG and I-ORG Technology I-ORG Committee I-ORG Grant O No. O 19411971400 B-AWARD funded O by O Jiajun O Yang O Funding O for O this O research O was O supported O by O the O Global O Ophthalmology O Awards O Program O GOAP O a O Bayer-sponsored O initiative O committed O to O supporting O ophthalmic O research O across O the O world O The O Jonas O Children’s O Vision O Care O and O Bernard O O Shirlee O Brown O Glaucoma O Laboratory O are O supported O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG P30EY019007 O R01EY018213 B-AWARD R01EY024698 B-AWARD R01EY026682 B-AWARD R24EY027285 B-AWARD U01EY030580 B-AWARD National B-ORG Cancer I-ORG Institute I-ORG Core O 5P30CA013696 O Foundation B-ORG Fighting I-ORG Blindness I-ORG TA-NMT-0116-0692-COLU O the O Research B-ORG to I-ORG Prevent I-ORG Blindness I-ORG RPB O Physician-Scientist B-AWARD Award O and O unrestricted O funds O from O RPB O New O York O NY, O USA O S.H.T O is O a O member O of O the O RD-CURE O Consortium O and O is O supported O by O Kobi O and O Nancy O Karp O the O Crowley O Family O Fund O the O Rosenbaum O Family O Foundation O the O Tistou O and O Charlotte O Kerstan O Foundation O the O Schneeweiss O Stem O Cell O Fund O New O York O State O C029572 O and O the O Gebroe O Family O Foundation O This O research O was O partially O supported O by O the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD1000502 O and O Modern B-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG CARS-33-YZ1 O awarded O to O WM.T O This O research O was O also O partially O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31700601 O awarded O to O J.C O This O research O was O funded O by O the O Grant B-ORG Agency I-ORG of I-ORG Charles I-ORG University I-ORG project I-ORG SVV I-ORG and I-ORG project I-ORG GAUK I-ORG 348721 B-AWARD The O research O was O also O funded O by O the O European B-ORG Regional I-ORG Development I-ORG Fund I-ORG OP I-ORG RDE I-ORG project O CZ.02.1.01/0.0/0.0/16_019/0000729 B-AWARD the O European B-ORG Social I-ORG Fund O OP O RDE O Project O “IOCB O Mobility O II” O No. O CZ.02.2.69/0.0/0.0/18_053/0016940 B-AWARD and O by O the O project O National B-ORG Institute I-ORG for I-ORG Research I-ORG of I-ORG Metabolic I-ORG and I-ORG Cardiovascular I-ORG Diseases I-ORG Programme O EXCELES O ID O Project O No. O LX22NPO5104)—Funded B-AWARD by O the O European O Union—Next O Generation O EU. O The O authors O disclosed O receipt O of O the O following O financial O support O for O the O research O authorship O and/or O publication O of O this O article O this O work O was O supported O by O the B-ORG Science I-ORG and I-ORG Education I-ORG for I-ORG Health I-ORG Foundation I-ORG of I-ORG Suzhou I-ORG for I-ORG Youth I-ORG Grant O Nos O kjxw2018030 B-AWARD and O kjxw2018032 B-AWARD the B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG Foundation I-ORG of I-ORG Suzhou I-ORG Grant O No. O SS201651 B-AWARD the B-ORG medical I-ORG key I-ORG discipline I-ORG foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grant O No. O ZDXKC2016007 B-AWARD and O the B-ORG Education I-ORG Research I-ORG Project I-ORG Foundation I-ORG of I-ORG Nanjing I-ORG Medical I-ORG University I-ORG Grant O No. O FZS-ZD-201701 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Number O 81803657 B-AWARD the O Guangdong B-ORG education I-ORG department I-ORG key I-ORG promotion I-ORG platform I-ORG construction I-ORG project I-ORG Linnan I-ORG key I-ORG laboratory I-ORG of I-ORG Chinese I-ORG medicine I-ORG resources I-ORG ministry I-ORG of I-ORG education I-ORG 2014KTSPT016 O Special B-ORG funds I-ORG for I-ORG the I-ORG construction I-ORG of I-ORG traditional I-ORG Chinese I-ORG medicine I-ORG in I-ORG Guangdong I-ORG province I-ORG No. O 20181075 B-AWARD and O the O earmarked O fund O for O Guangdong B-ORG education I-ORG department I-ORG innovation I-ORG strong I-ORG school I-ORG project I-ORG No. O E1-KFD015181K28/2017KQNCX039 O The O present O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 31371056 B-AWARD 31470051 I-AWARD 31701041 O Shanghai B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning—China I-ORG ZHYY-ZXYJHZX-2-22 O the O Shanghai B-ORG City I-ORG Committee I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Key I-ORG Project I-ORG No. O 17080503200 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 31701062 O and I-AWARD 31701439 O the O Hubei B-ORG Province I-ORG Educational I-ORG Commission I-ORG Foundation I-ORG Q20171307 O and O the O Plan B-ORG in I-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG Team I-ORG of I-ORG Outstanding I-ORG Young I-ORG Hubei I-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG T2017004 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81341035 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG LY16H090016,LQ19H090007 O Medicine B-ORG and I-ORG Health I-ORG Care I-ORG General I-ORG Studies I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2015KYA217 O Zhejiang B-ORG Provincial I-ORG Program I-ORG for I-ORG the I-ORG Cultivation I-ORG of I-ORG High-Level I-ORG Innovative I-ORG Health I-ORG Talents I-ORG 2012-RC-22 O the B-ORG Construction I-ORG Project I-ORG of I-ORG Anesthesiology I-ORG Discipline I-ORG Special I-ORG Disease I-ORG Center I-ORG in I-ORG Zhejiang I-ORG North I-ORG Region I-ORG 201524 O Jiaxing B-ORG city I-ORG science I-ORG and I-ORG technology I-ORG project I-ORG 2017AY33008 O 2018AY32012 O Design O and O data O collection O were O supported O by O the B-ORG Stroke I-ORG Screening I-ORG and I-ORG Intervention I-ORG Program I-ORG SSIP O implemented O by O the O National O Stroke O Prevention O Committee O of O China O 2013 O The O development O of O the O analytical O methods O and O software O used O in O this O work O was O supported O by O the B-ORG TCM I-ORG Leading I-ORG Talents I-ORG Training I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG SLJ0209 O and O the B-ORG Ph.D I-ORG startup I-ORG foundation I-ORG of I-ORG Jiangsu I-ORG Subei I-ORG People’s I-ORG Hospital I-ORG BSQDJ0055 O Writing O and O revising O the O manuscript O were O supported O in O part O by O the B-ORG Cadre I-ORG Health I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Health I-ORG Commission I-ORG BJ19011 O This O work O was O funded O by O the O Special B-ORG Fund I-ORG for I-ORG Clinical I-ORG Research I-ORG of I-ORG Wu I-ORG Jie I-ORG Ping I-ORG Medical I-ORG Foundation I-ORG grant O number O 320.2710.1816 B-AWARD the O Medical B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG Grant O number O A2017303 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG grant O number O 2017A020215161 B-AWARD This O study O was O supported O by O grants O from O the O Scientific B-ORG Research I-ORG Starting I-ORG Foundation I-ORG for I-ORG Doctor I-ORG of I-ORG North I-ORG Sichuan I-ORG Medical I-ORG College I-ORG No. O CBY16-QD05 O the B-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG Foundation I-ORG of I-ORG Sichuan I-ORG Province I-ORG No. O 2018JY0497 O and O the B-ORG National I-ORG and I-ORG Sichuan I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Training I-ORG Program I-ORG for I-ORG Undergraduates I-ORG No. O 201810634009 O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31471157 O and O 31700266 B-AWARD National B-ORG Foundation I-ORG for I-ORG Germplasm I-ORG Repository I-ORG of I-ORG Special I-ORG Horticultural I-ORG Crops I-ORG in I-ORG Central I-ORG Mountain I-ORG Areas I-ORG of I-ORG China I-ORG NJF2017-69 O National B-ORG Science I-ORG Fund I-ORG for O Distinguished O Young O Scholars O 30825030 O Key B-ORG Project I-ORG from I-ORG the I-ORG Government I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2013NZ0014 O 2016NZ0105 B-AWARD Key B-ORG Project I-ORG from I-ORG the I-ORG Government I-ORG of I-ORG Anhui I-ORG Province I-ORG 2012AKKG0739 O 1808085MC57 B-AWARD and O the O US O National B-ORG Science I-ORG Foundation I-ORG IOS-1339287 O and O IOS-1539831 B-AWARD This O research O was O funded O by O grants O AGL2012-3987-CO2-01 B-AWARD from O the O Ministerio B-ORG de I-ORG Economía I-ORG y I-ORG Competitividad I-ORG MINECO O Spain O and O PID-2019-110605RB-100 B-AWARD from O the O Ministerio B-ORG de I-ORG Ciencia I-ORG e I-ORG Innovación I-ORG MICINN O Spain O V. O Casado-del O Castillo O was O the O recipient O of O fellowship O AP2010-2742 B-AWARD from O the O Ministerio O de I-ORG Educación I-ORG Cultura I-ORG y I-ORG Deporte I-ORG MECD O Spain O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81341054 O 81171732 O Talented B-ORG Scholars I-ORG of I-ORG Wannan I-ORG Medical I-ORG College I-ORG YR202226 O Technology B-ORG Mountaineering I-ORG Program I-ORG of I-ORG Yijishan I-ORG Hospital I-ORG and I-ORG Wannan I-ORG Medical I-ORG College I-ORG PF2019005 O Science B-ORG and I-ORG Technology I-ORG Plan I-ORG Projects I-ORG of I-ORG WuHu I-ORG City I-ORG 2022jc61 O The O study O was O funded O by O the O Fundamental B-ORG and I-ORG Applied I-ORG Fundamental I-ORG Research I-ORG Major I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2019B030302004-05 O Hainan B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG 322CXTD530 O Hainan O Provincial O Natural O Science O Foundation O 322MS153 O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2019B121201001 O Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund O CAFS O 2020TD16 O Financial B-ORG Fund I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Agriculture I-ORG and I-ORG Rural I-ORG Affairs I-ORG P. I-ORG R. I-ORG of I-ORG China I-ORG NFZX2021 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 41571158 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFC1302602 B-AWARD the O National O Key O Research O and O Development O Program O of O China O No. O 2016YFC1201305 B-AWARD the O Shanghai B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG No. O 15GWZK0201 B-AWARD the O Innovation B-ORG Project I-ORG of I-ORG LREIS I-ORG No. O O8R8B6A0YA B-AWARD the O Fundamental O Research O Funds O for O the O Central O Universities O in O China O East O China O Normal O University O This O work O was O financially O supported O in O part O by O grants O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2016YFD0101006 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 31600989 B-AWARD the O Ministry O of O Science O and O Technology O 2016YFA0500800 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20150653 O and O the O JCIC-MCP O project O HRF O Grant O number O Finance O code O 001 B-AWARD Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG O Brazil O CAPES)https://www.capes.gov.br O Grant O number O 403754/2016-0 B-AWARD Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG O Brasil O CNPq)http://www.cnpq.br O Grant O number O TR B-AWARD 584 I-AWARD 2019 O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG e I-ORG Inovação I-ORG do I-ORG Estado I-ORG de I-ORG Santa I-ORG Catarina I-ORG FAPESC)http://www.fapesc.sc.gov.br O The O funders O had O no O role O in O study O design O ata O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O design O collection O analysis O of O the O study O and O interpretation O of O data O and O in O writing O the O manuscript O were O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81600152 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20160194 O and O Jiangsu B-ORG Province I-ORG Young I-ORG Medical I-ORG Talents I-ORG QNRC2016155 O L.M.O.L O was O financially O supported O by O the O National B-ORG Institute I-ORG of I-ORG Neurological I-ORG Disorders I-ORG and I-ORG Stroke I-ORG NINDS O of O the O National O Institutes O of O Health O NIH O under O Award O Number O T32NS048004 B-AWARD and O the O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health I-ORG NIMH O under O Award O Number O K99MH116115 B-AWARD R.A.O O is O supported O by O the O National B-ORG Institute I-ORG on I-ORG Aging I-ORG NIA O of O the O NIH O grant O RF1 B-AWARD AG058484 O The O study O was O funded O by O the O Bone B-ORG Tumors I-ORG and I-ORG Nervous I-ORG System I-ORG Tumors I-ORG Biobank I-ORG Project I-ORG of I-ORG Shanghai I-ORG 12DZ2295103 O Bone B-ORG Tumor I-ORG Sample I-ORG Databases I-ORG and I-ORG Digital I-ORG Information I-ORG Platform I-ORG Project I-ORG of I-ORG Shanghai I-ORG 08DZ2292800 O and O Shanghai B-ORG Biobank I-ORG Network I-ORG of I-ORG Common I-ORG Human I-ORG Tumor I-ORG Tissue I-ORG 12DZ2295100 O This O study O is O supported O by O the O National B-ORG Key I-ORG Technology I-ORG R&D I-ORG Program I-ORG No. O 2015BAI12B12 B-AWARD and O National B-ORG Clinical I-ORG Research I-ORG Center I-ORG for I-ORG Cancer I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Number O 81502648 B-AWARD Henan B-ORG Medical I-ORG Science I-ORG and I-ORG Technique I-ORG Foundation I-ORG Grant O Number O 201401016 B-AWARD Zhengzhou B-ORG Medical I-ORG Science I-ORG and I-ORG Technique I-ORG Foundation I-ORG Grant O Number O 153PKJGG061 B-AWARD Henan B-ORG Students I-ORG Studying I-ORG Abroad I-ORG Research I-ORG Foundation I-ORG Grant O Number O 2015-5 B-AWARD and O Henan B-ORG Provincial I-ORG Scientific I-ORG and I-ORG technological I-ORG project I-ORG Grant O Number O 162102310046 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31670812 O to O C.W O the O grant O for O Returned B-ORG Overseas I-ORG Chinese I-ORG Scholars I-ORG of I-ORG Hebei I-ORG Province I-ORG CY201602 O to O C.W O the O Hundreds B-ORG of I-ORG Outstanding I-ORG Talent I-ORG Innovation I-ORG Projects I-ORG in I-ORG Hebei I-ORG Province I-ORG SLRC2017023 O to O C. O W O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG C2018201171 O to O C.W O The O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 82171182 B-AWARD Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Tianjin I-ORG Municipal I-ORG Health I-ORG Committee I-ORG grant O number O ZC20121 B-AWARD and O KJ20048 B-AWARD and O Tianjin B-ORG Key I-ORG Medical I-ORG Discipline I-ORG Specialty I-ORG Construction I-ORG Project I-ORG No. O TJYXZDXK-052B B-AWARD This O work O was O supported O by O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 7184192 B-AWARD and O 7162015 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 21778011 B-AWARD China O Postdoctoral O Science O Foundation O funded O project O No. O 2017M620567 O Beijing B-ORG Postdoctoral I-ORG Research I-ORG Foundation I-ORG No. O 2018-ZZ-022 B-AWARD Chaoyang O District O Postdoctoral O Research O Foundation O No. O 2018ZZ-01-25 O and O Education O Commission O Science O and O Technology O Project O of O Beijing O Municipality O No. O PXM2015_014204_500175 O A.K O was O funded O by O the O Operational B-ORG Program I-ORG “Competitiveness I-ORG Entrepreneurship I-ORG and I-ORG Innovation” I-ORG NSRF O 2014–2020 O and O co-financed O by O GSRT B-ORG Greece I-ORG and I-ORG the I-ORG European I-ORG Union I-ORG European O Regional O Development O Fund O project O MIS B-AWARD 5002567 O implemented O under O the O “Action O for O the O Strategic O Development O on O the O Research O and O Technological O Sector” O initiative O This O work O was O partially O supported O by O NCSR B-ORG internal O project O No O EE11968 B-AWARD entitled O “Synthesis O and O characterization O of O nanostructured O materials O for O environmental O applications” O V.S O was O supported O by O a O research O grant O from O Regione B-ORG Lazio I-ORG PROGETTI I-ORG DI I-ORG GRUPPI I-ORG DI I-ORG RICERCA I-ORG 2020 O project O ID: O A0375-2020-36597 B-AWARD This O work O has O been O supported O by O research O grants O from O Associazione B-ORG Italiana I-ORG per I-ORG la I-ORG Ricerca I-ORG sul I-ORG Cancro I-ORG AIRC-IG2021-n.26230 B-AWARD and O the O Italian B-ORG Ministry I-ORG of I-ORG Health O RF-2016-02362022 B-AWARD The O work O of O D.B O and O C.C O was O also O supported O by O AIRC-IG2021-n.26230 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32272450 O the O Special B-ORG Research I-ORG Funds I-ORG for I-ORG Local I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Guided I-ORG by I-ORG Central I-ORG Government I-ORG 2022L3055 O the O Key B-ORG Projects I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG of I-ORG Fujian I-ORG Province I-ORG 2022G02024 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG 2020I0010 O 2020I0012 B-AWARD Special B-ORG Funds I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG of I-ORG Fujian I-ORG Agriculture I-ORG and I-ORG Forestry I-ORG University I-ORG CXZX2019101S O and O “13th B-ORG Five I-ORG Year I-ORG Plan” I-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG 2016YFD0400403 O This O work O was O supported O by O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province O China O No. O BK20181137 O the B-ORG Central I-ORG Public-Interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG Freshwater I-ORG Fisheries I-ORG Research I-ORG Center O CAFS O No. O 2019JBFC01 O and O the B-ORG Cooperative I-ORG Development I-ORG Project I-ORG of I-ORG Freshwater I-ORG Fisheries I-ORG Research I-ORG Center I-ORG and I-ORG Beijing I-ORG Yujing I-ORG Biotechnology I-ORG Co I-ORG Ltd O No. O 2019502700 O The O funder O Beijing O Yujing O Biotechnology O Co O Ltd O provided O support O in O the O form O of O salaries O for O author O HJJ O JWB O but O did O not O have O any O additional O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Fund B-ORG of I-ORG Transgenic I-ORG Breeding I-ORG for I-ORG Soybean I-ORG Resistance I-ORG to I-ORG Soybean I-ORG mosaic I-ORG virus I-ORG 2016ZX08004-004 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG KYT201801 O Program B-ORG for I-ORG Changjiang I-ORG Scholars I-ORG and I-ORG Innovative I-ORG Research I-ORG Team I-ORG in I-ORG University I-ORG PCSIRT_17R55 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31571690 O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31760392 O the O National B-ORG Soybean I-ORG Industrial I-ORG Technology I-ORG System I-ORG of I-ORG China I-ORG CARS-004 O Jiangsu B-ORG Collaborative I-ORG Innovation I-ORG Center I-ORG for I-ORG Modern I-ORG Crop I-ORG Production I-ORG JCIC-MCP O and O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0101501 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O U1701233 B-AWARD the O Special B-ORG Funds I-ORG for I-ORG Talents I-ORG in I-ORG Northwest I-ORG A&F I-ORG University I-ORG to O B. O Zhu O Program O No. O Z111021510 B-AWARD the O special B-ORG grade I-ORG of I-ORG the I-ORG financial I-ORG support I-ORG from I-ORG the I-ORG China I-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Program O No. O 2016T90956 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Program O No. O 2452017078 B-AWARD We O are O grateful O for O funding O provided O by O Jiangsu B-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG BM2015024 O Jiangsu B-ORG Province’s I-ORG Key I-ORG Medical I-ORG Center I-ORG No. O 201108 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81000748 B-AWARD and O 81000749 B-AWARD The O study O was O funded O by O a O Strategic O Award O from O the O Wellcome O Trust‐Imperial O College O Centre O for O Global O Health O Research O 100693/Z/12/Z O and O the O Imperial O College O London O Wellcome O Trust O Institutional O Strategic O Support O Fund O Global O Health O Clinical O Research O Training O Fellowship O 294834/Z O ISSF O ICL O R.M.C.‐L O is O supported O by O a O Wellcome O Trust O International O Training O Fellowship O 214185/Z/18/Z O M.L.‐P O receives O funding O from O the O Swiss O Excellence O Government O Scholarship O 2018.0698 O A.B.‐O O 103994/Z/14/Z O and O J.J.M O 074833/Z/04/Z O 205177/Z/16/Z O are O supported O by O the O Wellcome O Trust O J.J.M O acknowledges O receiving O additional O support O from O the O Alliance B-ORG for I-ORG Health I-ORG Policy I-ORG and I-ORG Systems I-ORG Research I-ORG HQHSR1206660 O the O Fogarty O International O Centre O R21TW009982 O D71TW010877 O Grand O Challenges O Canada O 0335‐04 O the O International O Development O Research O Centre O Canada O 106887 O 108167 O the O Inter‐American O Institute O for O Global O Change O Research O IAI O CRN3036 O the O Medical B-ORG Research I-ORG Council I-ORG MR/P008984/1 O MR/P024408/1 B-AWARD MR/P02386X/1 B-AWARD the O National O Cancer O Institute O 1P20CA217231 O the O National O Heart O Lung O and O Blood O Institute O HHSN268200900033C O 5U01HL114180 O 1UM1HL134590 O the O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health I-ORG 1U19MH098780 O the O Swiss O National O Science O Foundation O 40P740‐160366 O and O the O World O Diabetes O Foundation O WDF15‐1224 O This O work O was O supported O by O the O Science B-ORG and I-ORG Technology I-ORG Programs I-ORG of I-ORG Guangdong I-ORG Province I-ORG No.2019B020230004 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81870254 O and O the O ZHONGNANSHAN B-ORG MEDICAL I-ORG FOUNDATION I-ORG OF I-ORG GUANGDONG I-ORG PROVINCE I-ORG grant O number O NO.202151 B-AWARD This O work O was O supported O by O Chongqing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG NO. O cstc2018jcyjAX0762 O Chongqing B-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG Foundation I-ORG NO. O 2018MSXM112 O Project B-ORG of I-ORG Higher I-ORG Education I-ORG Teaching I-ORG Reform I-ORG of I-ORG Chongqing I-ORG NO. O 163216 O and O Project B-ORG of I-ORG Education I-ORG Teaching I-ORG Reform I-ORG of I-ORG Chongqing I-ORG Medical I-ORG and I-ORG Pharmaceutical I-ORG College I-ORG ygzjg201402 O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Polish B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Higher I-ORG Education I-ORG Grant I-ORG 12300051 B-AWARD UK O Engineering B-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG EPSRC O Grant O EP/V000969/1 B-AWARD ARGON O Royal B-ORG Society I-ORG International I-ORG Exchange I-ORG Grant O IEC\NSFC\211244 O Spanish B-ORG MICINN I-ORG grant O PID2021-128000OB-C21 B-AWARD PRECISION O and O Comunidad B-ORG de I-ORG Madrid I-ORG Grant O S2018/NMT-4326 B-AWARD SINFOTON2-CM O The O authors O acknowledge O financial O support O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 21607058 B-AWARD the O Department B-ORG of I-ORG Education I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. O Y201840526 B-AWARD and O the O Jiaxing O Clean O Production O Innovation O Team O of O Leather O and O Textile O Dyeing O O Finishing O the B-ORG key I-ORG project I-ORG of I-ORG Nanhu I-ORG college I-ORG of I-ORG Jiaxing I-ORG University I-ORG 2018 O and O the O key O project O of O Jiaxing O University O 2012 O This O research O is O funded O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFC1703802 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O U1801287 B-AWARD 81872842 B-AWARD 82073821 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2020A1515011061 O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG Nos O 2020B1111110004 B-AWARD and O 2018B020207008 B-AWARD and O the O Local B-ORG Innovative I-ORG and I-ORG Research I-ORG Teams I-ORG Project I-ORG of I-ORG Guangdong I-ORG Pearl I-ORG River I-ORG Talents I-ORG Program I-ORG No. O 2017BT01Y036 B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31160530 B-AWARD and O No. O 31360634 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG of I-ORG Jiangxi I-ORG Province I-ORG 20122BBF60074 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Province I-ORG 20114BAB214003 O and O the O Project B-ORG of I-ORG Education I-ORG Department I-ORG in I-ORG Jiangxi I-ORG Province I-ORG GJJ13289 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by: O TZ: O HAAFS B-ORG Agriculture I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG 2019-1-2-2 O and O HAAFS B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2018120304 O This O study O was O also O supported O by O Hebei B-ORG Province I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 20326518D B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 61571095 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG China I-ORG ZYGX2005Z006 O the O Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG 2018HH0154 O the O 2018 B-ORG Talent I-ORG Research I-ORG Program I-ORG of I-ORG Guizhou I-ORG University I-ORG 702569183301 O and I-AWARD 702570183301 O the O Science B-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG of I-ORG Guizhou I-ORG Province I-ORG of I-ORG China I-ORG (2018)5781 O and O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant I-ORG Grant O No. O 2019M653369 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The B-ORG Program I-ORG of I-ORG Guangxi I-ORG Zhuang I-ORG Autonomous I-ORG Region I-ORG Association I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG for I-ORG Young I-ORG Teachers I-ORG and I-ORG Graduate I-ORG Students I-ORG in I-ORG 2016 I-ORG Item O Number O gui B-AWARD ke I-AWARD xie〔2016〕Z-46 O The B-ORG Program I-ORG of I-ORG Humanities I-ORG and I-ORG Social I-ORG Science I-ORG Research I-ORG Center I-ORG of I-ORG Guangxi I-ORG Medical I-ORG University I-ORG for I-ORG Graduate I-ORG Students I-ORG in I-ORG 2016 I-ORG Item O Number O 2016RWY06 B-AWARD and O Innovation B-ORG Project I-ORG of I-ORG Guangxi I-ORG Graduate I-ORG Education I-ORG in I-ORG 2017 I-ORG Item O Number O YCSW2017114 B-AWARD This O study O was O supported O by O the O Anhui B-ORG University I-ORG Talent I-ORG project I-ORG gxbjZD2016024 O Talent B-ORG Research I-ORG Project I-ORG of I-ORG Anhui I-ORG Agricultural I-ORG University I-ORG yj2018-04 O the O National B-ORG Forestry I-ORG Public I-ORG Welfare I-ORG Profession I-ORG Scientific I-ORG Research I-ORG Special I-ORG Project I-ORG of I-ORG China I-ORG NO. O 201404601 B-AWARD and O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG NO. O 2017YFD0201203 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O is O supported O by O the B-ORG national I-ORG science I-ORG foundation I-ORG of I-ORG China I-ORG U160411067 B-AWARD U1404301 O the B-ORG national I-ORG research I-ORG project I-ORG training I-ORG fund I-ORG of I-ORG Henan I-ORG Normal I-ORG University I-ORG 5101049170805 B-AWARD and O the B-ORG key I-ORG scientific I-ORG research I-ORG programs I-ORG of I-ORG Henan I-ORG education I-ORG department I-ORG 17A610002 B-AWARD 14B180022 I-AWARD This O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Project O Nos O 81871736 B-AWARD 81802076 B-AWARD the B-ORG Medicine I-ORG and I-ORG Health I-ORG Care I-ORG Technology I-ORG Projects I-ORG of I-ORG Guangzhou I-ORG Project O No O 2017A013010017 B-AWARD Guangzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Foundation I-ORG Project O No O 201804020043 B-AWARD National B-ORG Key I-ORG Technology I-ORG R&D I-ORG Program I-ORG Project O No O 2018YFC1311902 B-AWARD Guangdong B-ORG Science I-ORG and I-ORG Technology I-ORG Foundation I-ORG Project O No O 2019B030316028 B-AWARD Guangzhou B-ORG Municipal I-ORG Health I-ORG Foundation I-ORG Project O No O 20191A011073 B-AWARD and O the B-ORG SKLRD I-ORG Foundation I-ORG Project O No O SKLRD-MS-201906 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O No O additional O external O funding O was O received O for O this O study O The O study O was O supported O by O the O Chinese B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG 81602868 O Shanghai B-ORG Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG 17411965300 O 17XD1402800 B-AWARD Shanghai B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG 20164Y0095 O These O funding O bodies O contributed O to O design O of O the O study O and O collection O analysis O and O interpretation O of O data O This B-ORG work I-ORG was I-ORG supported I-ORG by I-ORG the I-ORG National B-ORG Natural I-ORG Foundation I-ORG of I-ORG China I-ORG No O 81660213 B-AWARD 81360192 B-AWARD 81660706 O the O National B-ORG Foundation I-ORG of I-ORG Guangxi I-ORG No O 2017GXNSFAA198187 O 2018JJA140536 B-AWARD and O the O Guangxi O First-class O Discipline O Project O for O Pharmaceutical O Sciences O No. O GXFCDP-PS-2018 O PS O and O KS O are O thankful O toDepartment O of I-ORG Science I-ORG and I-ORG Technology I-ORG Science I-ORG and I-ORG Engineering I-ORG Research I-ORG Board(DST-SERB O File O No. O PDF/2016/003905 B-AWARD and O theDepartment O of I-ORG Biotechnology(DBT O Government O of O India O File O No. O BT/PR5426/AAQ/3/599/2012 B-AWARD for O financial O assistance O through O the O National O Postdoctoral O Fellowship O N-PDF O Scheme O BR O is O thankful O toUniversity O Grants I-ORG Commission(Government O of O India O for O the O financial O support O in O the O form O of O Postdoctoral O Fellowship O Grant O No. O PDFSS-20314-ST-MAH-4350 B-AWARD This O work O was O supported O by O the B-ORG Program I-ORG of I-ORG International I-ORG S I-ORG and I-ORG T I-ORG Cooperation I-ORG 2015DFA31580 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31401192 O 31271486 O the O Jilin B-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Neural I-ORG Plasticity I-ORG 20160622020JC O and O China B-ORG scholarship I-ORG council I-ORG 201506620038 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Open B-ORG Fund I-ORG of I-ORG the I-ORG National I-ORG Engineering I-ORG Laboratory I-ORG for I-ORG Digital I-ORG Construction I-ORG and I-ORG Evaluation I-ORG of I-ORG Urban I-ORG Rail I-ORG Transit O grant O number O 2021JZ02 B-AWARD Key B-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Transport O grant O number O 2021-ZD1-027 B-AWARD and O the O Pilot B-ORG Project I-ORG for I-ORG Building I-ORG China’s I-ORG Strength I-ORG in I-ORG Transport I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Transport O grant O number O QG2021-1-4-1 B-AWARD This O work O was O funded O by O the O Spanish B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Innovation I-ORG TED2021-129894B-I00 O The O study O forms O part O of O the O Advanced O Materials O programme O and O was O supported O by O MCIN O with O funding O from O European B-ORG Union I-ORG NextGenerationEU I-ORG PRTR-C17.I1 O and O Generalitat B-ORG Valenciana I-ORG MFA/2022/058 O DLS O FESEM O and O Fluorescence O lifetime O spectrometer O equipment O acquisition O funded O by O Generalitat B-ORG Valenciana–Conselleria I-ORG d’Educació I-ORG Investigació I-ORG Cultura I-ORG i I-ORG Esport I-ORG and O EUFEDER B-ORG “Una I-ORG forma I-ORG de I-ORG hacer I-ORG Europa” I-ORG GVA-IDIFEDER/2018/020 O and O GVA-IDIFEDER/2021/036 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 11004086 O 61675092 I-AWARD 61275046 I-AWARD 61475066 I-AWARD 61405075 I-AWARD 61601404 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2016A030313079 O 2016A030310098 I-AWARD 2016A030311019 I-AWARD 2014A030313377 I-AWARD 2015A030306046 I-AWARD 2015A030313320 O Special B-ORG Funds I-ORG for I-ORG Major I-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2019B010138004 O 2014B010120002 I-AWARD 2014B010117002 I-AWARD 2015B010125007 O Project O of O Guangzhou O Industry O Leading O Talents O CXLJTD-201607 O and O Planned O Science O O Technology O Project O of O Guangzhou O 2017A010102006 O 2016A010101017 O 2016B010111003 O 201506010046 O Joint O fund O of O pre-research O for O equipment O Ministry O of O Education O of O China O 6141A02022124 O Aeronautical B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 201708W4001 O Foundation B-ORG for I-ORG Distinguished I-ORG Young I-ORG Talents I-ORG in I-ORG Higher I-ORG Education I-ORG of I-ORG Guangdong I-ORG 2018KQNCX009 O 2018KQNCX279 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 21619402 O State O Key O Laboratory O of O Applied O Optics O SKLAO-201914 O John O Zweck O was O supported O by O the O US O National B-ORG Science I-ORG Foundation I-ORG under O Grant O No. O DMS-1620293 O Frank O Tittel O acknowledges O the O financial O support O from O the O US O National O Science O Foundation O NSF O ERC B-AWARD MIRTHE I-AWARD award O an O NSF O NeTS B-AWARD Large I-AWARD “ASTRO” I-AWARD award I-AWARD No. O R3H685 O and O grant O C-0586 B-AWARD from O the O Welch O Foundation O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81472475 B-AWARD and I-AWARD 81102007 O the O Chongqing B-ORG Science I-ORG I-ORG Technology I-ORG Commission I-ORG No. O cstc2016jcyjA0313 B-AWARD and O the O Scientific B-ORG Research I-ORG Foundation I-ORG of I-ORG Chongqing I-ORG Medical I-ORG University I-ORG No. O 201408 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O Shandong B-ORG Swine I-ORG Industry I-ORG Technology I-ORG System I-ORG Innovation I-ORG SDAIT-08-03 O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG SAAS I-ORG CXGC2017B02 O and O Youth B-ORG Research I-ORG Fund I-ORG of I-ORG SAAS I-ORG 2016YQN54 O The O funding O agency O provided O financial O support O for O the O research O but O was O not O involved O in O the O design O of O the O study O nor O collection O analysis O and O interpretation O of O data O or O in O writing O the O manuscript O This O work O was O supported O by O grants O from O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG China I-ORG No. O 2016CFB619 B-AWARD and O the O Clinical B-ORG Research I-ORG Physician I-ORG Program I-ORG of I-ORG Tongji I-ORG Medical I-ORG College I-ORG HUST I-ORG No. O 5001540017 B-AWARD and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81702989 B-AWARD This O work O was O supported O by O The B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81460007 O the B-ORG Cooperative I-ORG Innovation I-ORG Center I-ORG for I-ORG Old-age I-ORG Care I-ORG and I-ORG Geriatric I-ORG Health I-ORG of I-ORG Sichuan I-ORG Province I-ORG of I-ORG China I-ORG YLZBZ1515 O and O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Sichuan I-ORG provincial I-ORG department I-ORG of I-ORG education I-ORG of I-ORG China I-ORG 17A0130 O This O research O was O supported O by O the O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81672597 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG China I-ORG grant O number O LY17H160038 B-AWARD Key B-ORG Research-Development I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Province I-ORG grant O number O 2017C03013 B-AWARD 2019C04001 B-AWARD Science B-ORG and I-ORG Technology I-ORG Program I-ORG offered I-ORG by I-ORG Health I-ORG Bureau I-ORG of I-ORG Zhejiang I-ORG Province I-ORG China I-ORG 2012RCB006 O and O 2014KYA006 B-AWARD The O funding O bodies O had O no O role O in O study O design O collection O analysis O or O interpretation O of O data O or O in O writing O the O manuscript O This O work O was O supported O by O the O Science B-ORG Foundation I-ORG of I-ORG First I-ORG People’s I-ORG Hospital I-ORG of I-ORG ChenZhou I-ORG No. O N2013-006 B-AWARD Hunan B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 2017JJ3286 O the O Foundation B-ORG of I-ORG Hunan I-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG for I-ORG Special I-ORG Pathogens I-ORG Prevention I-ORG and I-ORG Control I-ORG Foundation I-ORG No. O 2014-5 B-AWARD and O the O Foundation B-ORG of I-ORG Chenzhou I-ORG municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG CZ2014029 O This O research O was O funded O by O the O Innovation B-ORG Program I-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Education I-ORG Commission I-ORG Grant O No. O 13ZZ103 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31270883 B-AWARD to O Zhou O Zhang O and O National B-ORG Science I-ORG Foundation I-ORG award I-ORG 1515028 O to O Christof O Grewer O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG ID: O 81371516 B-AWARD 81501441 O Social B-ORG Development I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BE2015605 O Foundation B-ORG of I-ORG National I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG China I-ORG W201306 O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG ID: O BK20150109 B-AWARD BK20150102 I-AWARD BK20131281 O Jiangsu B-ORG Province I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG Youth I-ORG Scientific I-ORG Research I-ORG Project I-ORG ID: O Q201508 B-AWARD Six B-ORG Talent I-ORG Peaks I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG ID: O 2015-WSN-079 B-AWARD and O Key B-ORG Project I-ORG supported I-ORG by I-ORG Medical I-ORG Science I-ORG and I-ORG technology I-ORG development I-ORG Foundation I-ORG Nanjing I-ORG Department I-ORG of I-ORG Health I-ORG YKK15068 O The O opinions O results O and O conclusions O reported O in O this O paper O are O those O of O the O authors O and O are O independent O from O the O funding O sources O The O study O was O supported O by O National B-ORG Science I-ORG Foundation I-ORG No. O 81271327 B-AWARD Guangdong B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG NO.2015A03013167 O Science&technology B-ORG Project I-ORG of I-ORG Guangzhou I-ORG NO.201510010251 O This O research O was O funded O by O Taipei B-ORG Medical I-ORG University I-ORG grant O TMU108-AE1-B12 O a O grant O from O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Taiwan I-ORG MOST O 109-2314-B-038-021-MY3 O and O grants O from O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Council I-ORG Taiwan I-ORG NSTC O 111-2622-B-038-008 O NSTC B-AWARD 112-2823-8-038-001 O This O research O was O funded O in O part O by O the B-ORG Major I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Hainan I-ORG Province I-ORG under O grant O ZDKJ2020013 B-AWARD the B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG Hainan I-ORG Province I-ORG under O grant O ZDYF2020041 B-AWARD the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Innovation I-ORG Research I-ORG Team I-ORG Project I-ORG of I-ORG Hainan I-ORG Province I-ORG under O grant O 320CXTD431 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O grant O 32060413 B-AWARD and O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG China I-ORG under O grant O 2021YFB1507104 B-AWARD This O work O was O supported O by O the O National B-ORG Key I-ORG Project I-ORG for I-ORG Research I-ORG on I-ORG Transgenic I-ORG Biology I-ORG China I-ORG 2016ZX08002-001-004 O to O Z.Z O Natural B-ORG e I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31771789 B-AWARD to O Z.Z O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG of I-ORG China I-ORG Grant O No. O 2022JJ31002 B-AWARD to O L.Z O Jiang O Zhang O received O the O following O three O funds O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31971681,http://www.nsfc.gov.cn O Jiangsu B-ORG Province I-ORG Forestry I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG and I-ORG Promotion I-ORG Project I-ORG LYKJ O 2018]36,http://jsf.jiangsu.gov.cn O and O Nantong B-ORG University I-ORG Scientific I-ORG Research I-ORG Start-up I-ORG project I-ORG for I-ORG Introducing I-ORG Talents I-ORG 18R08,http://www.ntu.edu.cn O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Supported O by O the O Ministry B-ORG of I-ORG Education I-ORG Youth I-ORG and I-ORG Sport I-ORG Project O No O LTAUSA19117 B-AWARD the O Ministry B-ORG of I-ORG Agriculture I-ORG of I-ORG the I-ORG Czech I-ORG Republic I-ORG grant O ID: O MZE-RO0718 B-AWARD and O projects O NAZV O QK1910320 B-AWARD and O QK1910059 B-AWARD and O South B-ORG Bohemia I-ORG University I-ORG project O GAJU O 005/2022/Z B-AWARD We O thank O the O Shanghai B-ORG Key I-ORG Lab I-ORG of I-ORG Human I-ORG Performance I-ORG Shanghai O University O of O Sport O No. O 11DZ2261100 B-AWARD and O Directed B-ORG Research I-ORG Grants I-ORG from I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG No. O 18DZ1200600 B-AWARD and O the O Graduate B-ORG Abroad I-ORG Visiting I-ORG Program I-ORG from I-ORG Shanghai I-ORG University I-ORG of I-ORG Sport I-ORG China I-ORG No. O STFX20190104 B-AWARD This O work O was O supported O by O the O Chang B-ORG Gung I-ORG Medical I-ORG Foundation I-ORG CMRPG2F0081 O CMRPG2F0082 B-AWARD CMRPG2F0083 B-AWARD CMRPD3F0021 B-AWARD CMRPD3F0022 B-AWARD CMRPD3F0023 B-AWARD NARPD3J0021 B-AWARD NARPD3J0022 B-AWARD and O NARPD3L0061 B-AWARD the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Taiwan I-ORG 108-2410-H-182-008-MY2 O and O 110-2410-H-182-013-MY3 B-AWARD and O the O Wang B-ORG Jhan-Yang I-ORG Public I-ORG Trust I-ORG Fund I-ORG WJY O 2020-HR-01 O WJY B-AWARD 2021-HR-01 O WJY B-AWARD 2022-HR-01 O WYJ B-AWARD 2021-AP-01 I-AWARD and O WYJ B-AWARD 2022-AP-01 O This O study O was O supported O in O part O by O the O Special O Funding O of O Guiyang B-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG and I-ORG Guiyang I-ORG University I-ORG GYU-KYZ-2018-02-08 O the O Training B-ORG Program I-ORG for I-ORG High-level I-ORG Innovative I-ORG Talents I-ORG of I-ORG Guizhou I-ORG Province I-ORG 20164020 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guizhou I-ORG Educational I-ORG Committee I-ORG 2014277 O the O Program B-ORG for I-ORG First-class I-ORG Discipline I-ORG Construction I-ORG in I-ORG Guizhou I-ORG Province I-ORG 201785 O and O the O Engineering B-ORG Research I-ORG Center I-ORG of I-ORG Pest I-ORG Ecological I-ORG Management I-ORG in I-ORG Guizhou I-ORG Province I-ORG 1491 O This O study O was O funded O by O the O Three-year-action-project B-ORG of I-ORG Shanghai I-ORG Hospital I-ORG Development I-ORG center I-ORG No: O 16CR3062B B-AWARD the O Medical-Engineering B-ORG cross I-ORG fund I-ORG of I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG No: O YG2017QN46 B-AWARD and O the O Doctorial B-ORG Innovation I-ORG Fund I-ORG of I-ORG School I-ORG of I-ORG Medicine I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG No: O CBXJ201804 B-AWARD Medical-Engineering O cross O fund O of O Shanghai O Jiao O Tong O University O and O Doctorial O Innovation O Fund O of O School O of O Medicine O Shanghai O Jiao O Tong O University O contributed O in O conception O and O design O of O the O study O and O three-year-action-project O of O Shanghai O Hospital O Development O center O contributed O in O acquisition O analysis O and O interpretation O of O data O This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0201006 O to O Yansu O Li, O the B-ORG Earmarked I-ORG fund I-ORG for I-ORG Modern I-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG CARS-25-C-01 O to O Xianchang O Yu, O the B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG CAAS-ASTIP-IVFCAAS O to O Xianchang O Yu, O and O the O Key O Laboratory O of O Horticultural O Crop O Biology O and O Germplasm O Innovation O Ministry O of O Agriculture O China O The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFB0702203 O the O International O Cooperation O Fund O of O Shanghai O Science O and O Technology O Commission O 17520731800 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO. O U1460202 O the O National O program O for O the O Young O Top-notch O Professionals O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG N170205002 O and O the O Key O Laboratory O of O Superlight O Material O and O Surface O Technology O Harbin O Engineering O University O Ministry O of O Education O This O research O was O funded O by O the O EPSRC B-ORG Large I-ORG Baseline I-ORG Quantum-Enhanced I-ORG Imaging I-ORG Networks I-ORG Grant O No. O EP/V021303/1 B-AWARD the O EPSRC B-ORG Quantum I-ORG Communications I-ORG Hub I-ORG Grant O No. O EP/M013472/1 B-AWARD the O Horizon B-ORG Europe I-ORG EIC I-ORG Pathfinder I-ORG project I-ORG QuCoM I-ORG Grant O Agreement O No. O 101046973 B-AWARD the O Deutsche B-ORG Forschungsgemeinschaft I-ORG DFG O German O Research O Foundation O project O number O BR B-AWARD 5221/4-1 O the O European B-ORG Union’s I-ORG Horizon I-ORG 2020 I-ORG FET-Open I-ORG project I-ORG TEQ I-ORG Grant O Agreement O No. O 766900 B-AWARD the O Leverhulme B-ORG Trust I-ORG Research I-ORG Project I-ORG Grant I-ORG UltraQuTe I-ORG grant O RPG-2018-266 B-AWARD the O Royal B-ORG Society I-ORG Wolfson I-ORG Fellowship I-ORG RSWF/R3/183013 O the O UK B-ORG EPSRC I-ORG EP/T028424/1 O and O the O Department B-ORG for I-ORG the I-ORG Economy I-ORG Northern I-ORG Ireland I-ORG under I-ORG the I-ORG US–Ireland I-ORG R&D I-ORG Partnership I-ORG Program I-ORG USI O 175 I-AWARD and O USI B-AWARD 194 O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016 B-AWARD YFC I-AWARD 1306300 O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 I-ORG Program I-ORG No. O 2013CB530805 B-AWARD Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Nos O 7173264 B-AWARD 7172076 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No.10300-31042110 O and O the O Beijing B-ORG Normal I-ORG University I-ORG No. O 11100704 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-41 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 31601936 O and O the B-ORG Thirteenth I-ORG Five I-ORG Year I-ORG Plan I-ORG for I-ORG breeding I-ORG programs I-ORG in I-ORG Sichuan-Selective I-ORG breeding I-ORG of I-ORG new I-ORG breeds I-ORG and I-ORG the I-ORG synthetic I-ORG strains I-ORG in I-ORG laying I-ORG hens I-ORG 2016NYZ0050 O This O material O is O based O upon O work O supported O by O the O Office B-ORG of I-ORG Naval I-ORG Research I-ORG MURI O grant O no. O N00014-10-1-0952 B-AWARD N.B O and O K.M O were O also O supported O by O the O Air B-ORG Force I-ORG Office I-ORG of I-ORG Scientific I-ORG Research I-ORG grant O no. O FA9550-14-1-0398 B-AWARD and O N.B O was O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG NSF O Graduate O Research O Fellowship O Program O DGE-1256082 O D.T O N.F O Z.W O and O M.B O were O also O supported O by O NSF O grant O no. O 0910908 B-AWARD and O J.P O and O D.G O were O supported O by O NSF O grant O no. O 0313250 B-AWARD This O study O was O supported O and O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81302140 B-AWARD 81672408 B-AWARD 81874057 B-AWARD 81972741 B-AWARD Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG Grant O No. O 2020A1515010341 B-AWARD Medical B-ORG Science I-ORG Foundation I-ORG of I-ORG Sun I-ORG Yat-sen I-ORG University I-ORG Grant O No. O 19ykpy109 B-AWARD Guangdong B-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG 2017B030314026 O This O study O was O supported O by O Prostate B-ORG Cancer I-ORG Foundation I-ORG Young B-AWARD Investigator I-AWARD Award I-AWARD to O Dr O Nicholas O George O Nickols O Stop B-ORG Cancer I-ORG Career B-AWARD Development I-AWARD Award I-AWARD to O Dr O Nicholas O George O Nickols O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG grant O R01GM27681 B-AWARD to O Peter O B O Dervan O Jonsson B-ORG Cancer I-ORG Center I-ORG Foundation I-ORG Seed B-AWARD Grant I-AWARD to O Dr O Nicholas O George O Nickols O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 61762030 B-AWARD the O Innovation-driven B-ORG Development I-ORG Special I-ORG Fund I-ORG of I-ORG Guangxi O grant O number O AA1720417 B-AWARD the O Scientific B-ORG Research I-ORG and I-ORG Technology I-ORG Development I-ORG Program I-ORG of I-ORG Guangxi O grant O number O AB16380237 B-AWARD This O work O was O supported O in O part O by O funding O granted O by O Secretaría B-ORG de I-ORG Investigación I-ORG y I-ORG Vinculación I-ORG Tecnológica I-ORG from O Universidad O Católica O de O Córdoba O Accredited O project O Nutritional O Quality O a O key O factor O that O modulates O the O composition O of O the O intestinal O microbiota O and O the O metabolic O immune O response O in O models O of O obesity O RR B-AWARD 2267-19 O This O work O was O supported O in O part O by O funding O granted O by O Secretaría B-ORG de I-ORG Ciencia I-ORG y I-ORG Tecnología I-ORG from I-ORG Universidad I-ORG Nacional I-ORG de I-ORG Córdoba I-ORG SECyT O Accredited O projects O A) O Influence O of O nutritional O quality O innate O immunity O and O acute O infection O with O Trypanosoma O cruzi O in O a O diet-induced O obesity O model O Impact O on O development/prevention O of O non-communicable O chronic O diseases O Amount O Res O SECyT-UNC B-AWARD 411/2018 O B) O Identification O of O mononuclear O cell O metabolic O state O inT.cruziinfection O and O its O impact O on O the O inflammatory O response O SECyT-UNC B-AWARD 113/2018 O This O work O was O supported O in O part O by O LACE B-ORG Laboratories I-ORG SA. I-ORG Part O of O this O research O was O sponsored O by O FWO O Fonds O Wetenschappelijk I-ORG Onderzoek I-ORG – O Vlaanderen O grant O G.0B23.17N B-AWARD This O work O was O supported O in O part O by O grants O from O Fondo B-ORG de I-ORG Investigación I-ORG Sanitaria I-ORG www.isciii.es O PI15/00713 O Plan B-ORG Nacional I-ORG de I-ORG I+D+I I-ORG and I-ORG Fondo I-ORG Europeo I-ORG de I-ORG Desarrollo I-ORG Regional-FEDER I-ORG www.red.es/redes/inicio O RD16/0025/0040 O Fundación B-ORG Progreso I-ORG y I-ORG salud I-ORG Junta I-ORG de I-ORG Andalucía I-ORG http://www.juntadeandalucia.es/fundacionprogresoysalud/es O PI-0411-2014 O and O GEHEP-SEIMC B-ORG GEHEP-004 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O project O was O funded O by O USDA B-ORG CSREES I-ORG Grant O No. O 2009-34283-20087 B-AWARD between I-AWARD the I-AWARD USDA I-AWARD and I-AWARD the I-AWARD University I-AWARD of I-AWARD Illinois O Emily O Lankau O was O funded O by O a O US B-ORG Environmental I-ORG Protection I-ORG Agency I-ORG Science I-ORG to I-ORG Achieve I-ORG Results I-ORG Fellowship I-ORG during I-ORG sample I-ORG collection I-ORG and I-ORG analysis I-ORG STAR I-ORG Research I-ORG Assistance I-ORG Agreement I-ORG No. O 91684301-1 B-AWARD awarded I-AWARD by I-AWARD the I-AWARD U.S I-AWARD Environmental I-AWARD Protection I-AWARD Agency O Emily O Lankau O was O also O partially O funded O by O NSF B-ORG EID I-ORG Grant O No. O 1518611 B-AWARD at I-AWARD the I-AWARD University I-AWARD of I-AWARD Wisconsin I-AWARD during O manuscript O preparation O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O Natural O Science I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG Shaanxi O grant O number O 2023-JC-QN-0407 O and O 2023-JC-YB-320 B-AWARD Natural O Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 52035010 O and O 52275372 B-AWARD Fundamental O Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities O grant O number O ZYTS23012 O And O the O APC O was O funded O by O ZYTS23012 O This O work O was O partially O supported O by O Japan B-ORG Science I-ORG and I-ORG Technology I-ORG Agency I-ORG Core I-ORG Research I-ORG for I-ORG Evolutional I-ORG Science I-ORG and I-ORG Technology I-ORG Grant O No. O JPMJCR18H3 B-AWARD the B-ORG program I-ORG for I-ORG Brain I-ORG Mapping I-ORG by I-ORG Integrated I-ORG Neurotechnologies I-ORG for I-ORG Disease I-ORG Studies I-ORG from I-ORG Japan I-ORG Agency I-ORG for I-ORG Medical I-ORG Research I-ORG and I-ORG development I-ORG Grant O No. O JP20dm0207073 B-AWARD Grant-in-Aid B-ORG for I-ORG Scientific I-ORG Research I-ORG C) O Grant O No. O 18K07388 B-AWARD the B-ORG Collaborative I-ORG Research I-ORG Project I-ORG of I-ORG Brain I-ORG Research I-ORG Institute I-ORG Niigata I-ORG University I-ORG 2021-20012 O This O work O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG no. O ZR2017PF011 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Funds I-ORG of I-ORG China I-ORG no. O E020701 B-AWARD and O the O Doctoral B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Binzhou I-ORG University I-ORG no. O 2014Y10 B-AWARD This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81802323 B-AWARD and O No. O 81702414 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG of I-ORG China I-ORG No. O 2017Y0084 B-AWARD and O No. O 2015J01557 B-AWARD Science B-ORG and I-ORG Technology I-ORG Service I-ORG Network I-ORG Initiative I-ORG Foundation I-ORG of I-ORG CAS I-ORG No. O 2016T3009 B-AWARD the O Fujian B-ORG Provincial I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG Foundation I-ORG of I-ORG Youth I-ORG Scientific I-ORG Research I-ORG Project I-ORG No. O 2015-2-43 B-AWARD and O Xiamen B-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG Foundation I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG for I-ORG the I-ORG Benefit I-ORG of I-ORG the I-ORG People I-ORG No. O 3502Z20164010 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81702754 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2016A030313849 O and O the O Guangdong B-ORG Medical I-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Fund I-ORG C2018063 O The O funding O sources O had O no O role O in O the O design O and O conduct O of O the O study O collection O management O analysis O and O interpretation O of O the O data O preparation O review O or O approval O of O the O manuscript O and O decision O to O submit O the O manuscript O for O publication O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51502094 O Special B-ORG Fund I-ORG Project I-ORG for I-ORG Guangdong I-ORG Academy I-ORG of I-ORG Sciences I-ORG to I-ORG Build I-ORG First-Class I-ORG Research I-ORG Institutions I-ORG in I-ORG China I-ORG 2020GDASYL-20200103038 O National B-ORG Key I-ORG R I-ORG I-ORG D I-ORG Plans I-ORG 2018YFC1105902 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017M612657 O Guangdong B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG 2013B021800137 O Pearl B-ORG River I-ORG Nova I-ORG Program I-ORG of I-ORG Guangzhou I-ORG 201610010168 O and O Guangdong B-ORG Province I-ORG Medical I-ORG Research I-ORG Foundation I-ORG A2016060 O B.M.S O was O supported O by O the O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG BBSRC O BB/N000129/1 B-AWARD P.E O and O C.C.R O were O supported O by O H.E.F.C.E O University O of O Kent O and O by O the O BBSRC O BB/N000463/1 O J.M.G O and O E.L.L O were O supported O by O the O Eunice B-ORG Kennedy I-ORG Shriver I-ORG National I-ORG Institute I-ORG of I-ORG Child I-ORG Health I-ORG and I-ORG Human I-ORG Development I-ORG of O the O National O Institutes O of O Health O R01-HD073439 O and O R01-HD094787 B-AWARD and O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG R01-GM098536 O E.E.K.K O was O supported O by O the O National O Science O Foundation O Graduate O Research O Fellowship O Program O under O Grant O No. O DGE-1313190 O This O study O was O funded O by O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 O Program O grant O number O 2015CB755500 B-AWARD Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province O China O grant O number O 2012B031800102 B-AWARD 2016A020213004 B-AWARD Guangzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG key I-ORG projects I-ORG grant O number O 201803010056 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81572500 B-AWARD and O Hunan B-ORG Young I-ORG Talents I-ORG grant O number O 2016RS3036 B-AWARD All O of O them O play O a O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81402854 B-AWARD the O National B-ORG Key I-ORG Specialty I-ORG Construction I-ORG Project I-ORG of I-ORG Clinical I-ORG Pharmacy I-ORG 30305030698 O This O work O was O also O supported O by O a O grant O from O the O President B-ORG Foundation I-ORG of I-ORG Nanfang I-ORG Hospital I-ORG Southern I-ORG Medical I-ORG University I-ORG 2014033 O G.S O is O supported O by O grant O MS20/00064 B-AWARD from O the O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III I-ORG Spain I-ORG and I-ORG the I-ORG European I-ORG Social I-ORG Fund O as O well O as O grant O PID2019-104700GA-I00/AEI/10.13039/501100011033 B-AWARD funded O by O the O Agencia B-ORG Estatal I-ORG de I-ORG Investigación I-ORG AEI I-ORG Spain O G.S O is O also O supported O by O the O NIH B-ORG grant O R01HG010898-01 B-AWARD This O work O was O supported O by O the O Technology O Innovation O Program O and O the O Korea O Industrial O Complex O Corporation O Project O funded O by O the O Ministry B-ORG of I-ORG Trade I-ORG Industry I-ORG I-ORG Energy I-ORG MOTIE O Korea O grant O numbers O 20009356 B-AWARD and O IRGJ2203 B-AWARD a O National O Research O Foundation O of O Korea O grant O funded O by O the O Korean B-ORG government I-ORG MSIT O grant O number O 2021R1C1C1004147 B-AWARD and O the O Bio O O Medical O Technology O Development O Program O of O the O National O Research O Foundation O funded O by O the O Ministry B-ORG of I-ORG Science I-ORG I-ORG ICT I-ORG grant O number O 2022M3A9B6082670 B-AWARD This O project O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG 13151039 O Medical B-ORG Innovation I-ORG Subject I-ORG in I-ORG Fujian I-ORG Province I-ORG 2014-CX-22 O Key O Clinical O Specialty O Discipline O Construction O Program O of O Fujian O People’s O Republic O of O China O and O Young B-ORG and I-ORG Middle-aged I-ORG Teachers I-ORG Education I-ORG Scientific I-ORG Research I-ORG Project I-ORG in I-ORG Fujian I-ORG Province I-ORG JAT160796 O This O research O was O funded O by O Eyas B-ORG Program I-ORG Incubation I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Provincial I-ORG Administration I-ORG for I-ORG Market I-ORG Regulation I-ORG No. O CY2022003 B-AWARD NQI B-ORG Project I-ORG of I-ORG Zhejiang I-ORG Provincial I-ORG Administration I-ORG for I-ORG Market I-ORG Regulation I-ORG 2021012 O Opening B-ORG Fund I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Fire I-ORG Science I-ORG Grant O No. O HZ2022-KF02 B-AWARD and O Basic B-ORG Scientific I-ORG Research I-ORG Fund I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. O 2022YW18 B-AWARD The O project O described O was O supported O by O the O Clinical O and O Translational O Science O Award O CTSA O program O previously O through O the O National B-ORG Center I-ORG for I-ORG Research I-ORG Resources I-ORG NCRR O grant O 1UL1RR025011 B-AWARD and O now O by O the O National B-ORG Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences I-ORG NCATS O grant O 9U54TR000021 B-AWARD The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O National O Institutes O of O Health O the O Department O of O Veterans O Affairs O or O the O United O States O government O This O project O was O also O supported O by O the O University B-ORG of I-ORG Wisconsin I-ORG Carbone I-ORG Cancer I-ORG Center I-ORG UWCCC O Support O Grant O from O the O National O Cancer O Institute O grant O number O P30 B-AWARD CA014520 O Additional O support O was O provided O by O the O UW O School O of O Medicine O and O Public O Health O from O the O Wisconsin O Partnership O Program O This O study O was O funded O by O National B-ORG Key I-ORG Technologies I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0101002 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31871526 O 61705195 B-AWARD and O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018T110594 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 52103191 O the O Scientific B-ORG Research I-ORG project I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG in I-ORG Henan I-ORG Province I-ORG 2019ZY1007 O and O the O Start-up O Grant O 32340144 O from O Zhengzhou B-ORG University I-ORG This O work O was O financially O supported O by O the O Joint B-ORG Funds I-ORG for I-ORG the I-ORG Innovation I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Fujian I-ORG Province I-ORG Grant O No. O 2019Y9001 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG Grant O No. O 2020J01599 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 32027801 B-AWARD and O Fujian B-ORG Medical I-ORG University I-ORG Foundation I-ORG for I-ORG the I-ORG Introduction I-ORG of I-ORG Talents I-ORG Grant O No. O XRCZX2019018 B-AWARD XRCZX2017020 B-AWARD and O XRCZX2019005 B-AWARD This O work O was O supported O by O grants O from O the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Guangdong I-ORG province I-ORG No. O 2015A020209034 B-AWARD Ocean B-ORG Fisheries I-ORG Science I-ORG and I-ORG Technology I-ORG Promotion I-ORG Project I-ORG of I-ORG Guangdong I-ORG province I-ORG No. O A201601A06 B-AWARD China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-49 O and O the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Guangzhou I-ORG No. O 20134411115 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. I-AWARD 31360549 I-AWARD and O 31360549 O Major B-ORG Program I-ORG on I-ORG Basic I-ORG Research I-ORG Projects I-ORG of I-ORG Yunnan I-ORG Province I-ORG Grant O No. I-AWARD 2014FC006 O and O the B-ORG Talent I-ORG Project I-ORG of I-ORG Young I-ORG and I-ORG Middle-aged I-ORG Academic I-ORG Technology I-ORG Leadership I-ORG in I-ORG Yunnan I-ORG Province I-ORG Grant O No. I-AWARD 2013HB073 O This O work O was O supported O by O a O project O grant O from O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangxi I-ORG Province I-ORG Project O 2013GXNSFAA019258 B-AWARD a O project O grant O from O the O Research B-ORG Foundation I-ORG of I-ORG Guangxi I-ORG Medical I-ORG and I-ORG Health I-ORG Project O S201612 B-AWARD and O a O project O grant O from O the O Self-raised B-ORG Foundation I-ORG of I-ORG Guangxi I-ORG Health I-ORG Commission I-ORG Project O Z2016093 O SGH O and O ACN O were O supported O by O theMRC/EPSRC O UK I-ORG MEGPartnership O award O MR/K005464/1 O and O theNational O Institute I-ORG for I-ORG Health I-ORG Research(NIHR O Oxford O Biomedical O Research O Centre O based O at O Oxford O University O Hospitals O NHS O Trust O oxfbrc-2012-1 O ACN O additionally O was O supported O by O aWellcome O Trust I-ORG Senior I-ORG Investigator I-ORG Award(104571/Z/14/Z O FvE O was O supported O by O aMarie O Skłodowska-Curie I-ORG Individual I-ORG Fellowship(ACCESS2WM O from O the O European O Commission O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0500503 O the O Technical B-ORG System I-ORG Project I-ORG of I-ORG the I-ORG National I-ORG Herbage I-ORG Industry I-ORG China I-ORG CARS-34 O and O the O Major O Program O of O the O Natural B-ORG Scientific I-ORG Foundation I-ORG of I-ORG Inner I-ORG Mongolia I-ORG Autonomous I-ORG Region I-ORG China I-ORG 2014ZD02 O and O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Inner I-ORG Mongolia I-ORG China I-ORG 201502098 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the O Scientific B-ORG Research I-ORG Project I-ORG of I-ORG Education I-ORG Department I-ORG of I-ORG Hunan I-ORG Province I-ORG Grant O No. O 21A0179 B-AWARD in O part O by O the O Changsha B-ORG Municipal I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O No. O kq2014160 B-AWARD in O part O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG Grant O No. O 2021JJ41087 B-AWARD in O part O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 61902436 B-AWARD in O part O by O the O Hunan B-ORG Key I-ORG Laboratory I-ORG of I-ORG Intelligent I-ORG Logistics I-ORG Technology I-ORG 2019TP1015 O This O work O was O supported O by O grants O from O the O Fujian B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O no. O 2017J01232 B-AWARD Fujian B-ORG Provincial I-ORG Maternity I-ORG and I-ORG Children’s I-ORG Hospital I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O no. O YCXM18–18 B-AWARD and O Fujian B-ORG Provincial I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG Innovation I-ORG Project I-ORG Grant O no. O 2009-CXB-33 B-AWARD The O present O study O was O supported O by O the B-ORG National I-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81660770 B-AWARD the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Province I-ORG Grant O No. O 20161BAB215256 B-AWARD and O the B-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG Technology I-ORG Plan I-ORG of I-ORG Jiangxi I-ORG Province I-ORG Grant O No. O 20171105 B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81371284 B-AWARD 81570403 I-AWARD U1732157 O the O Anhui B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O No. O 1408085MH157 B-AWARD 1708085MH187 I-AWARD 1808085MH252 O the O Science B-ORG and I-ORG Technology I-ORG Research I-ORG Project I-ORG of I-ORG Anhui I-ORG Province I-ORG Grant O No. O 1501041147 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Province I-ORG Department I-ORG of I-ORG Education I-ORG Grant O No. O KJ2018ZD021 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81560470 O 81773127 I-AWARD and O 81960543 B-AWARD the O Special B-ORG Foundation I-ORG of I-ORG Young I-ORG and I-ORG Middle-Aged I-ORG Academic I-ORG Leaders I-ORG Reserve I-ORG Talent I-ORG in I-ORG Yunnan I-ORG Province I-ORG 2015HB086 O Special B-ORG Funds I-ORG for I-ORG High-Level I-ORG Medical I-ORG Leaders I-ORG in I-ORG Yunnan I-ORG Province I-ORG L-2017025 O and O Yunnan B-ORG Province I-ORG Basic I-ORG Research I-ORG Program I-ORG 2018FE001-058/246 O Haiyan O Xiao O was O supported O by O the O NSAF B-ORG Joint I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No.U1530129 O Zijiang O Liu O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 11464025 B-AWARD and O the O New B-ORG Century I-ORG Excellent I-ORG Talents I-ORG in I-ORG University I-ORG under O Grant O No. O NECT-11-0906 B-AWARD and O the O Key O Talent O Foundation O of O Gansu O Province O This O research O was O funded O by O the O Start-up B-ORG Funding I-ORG from I-ORG Qilu I-ORG University I-ORG of I-ORG Technology I-ORG Shandong O Academy O of O Sciences O grant O number O 81110696 B-AWARD and O 81110592 B-AWARD the O Program B-ORG for I-ORG New I-ORG Century I-ORG Excellent I-ORG Talents I-ORG in I-ORG University I-ORG of I-ORG China O grant O number O NCET-13-0711 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 31971605 B-AWARD the O QUTJBZ B-ORG Program O grant O number O 2022JBZ01-05 B-AWARD This O work O is O supported O by O the O American B-ORG Cancer I-ORG Society I-ORG Research I-ORG grant I-ORG IRG-82-003-27 B-AWARD the B-ORG Centers I-ORG of I-ORG Biomedical I-ORG Research I-ORG Excellence I-ORG COBRE I-ORG grant I-ORG GM103534 B-AWARD the O start-up O funding O package O from O the O Geisel O School O of O Medicine O at O Dartmouth O College O to O C.C O and O the B-ORG Taiwan I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG MOST O 104-2621-M-005-005-MY3 I-AWARD and O MOST B-AWARD 104-2320-B-005-005 O to O C.C.L O This O study O was O supported O by O Technology B-ORG Innovation I-ORG Program I-ORG of I-ORG Hunan I-ORG Province I-ORG Grant O No. O 2017SK50901 B-AWARD Scientific B-ORG Research I-ORG Program I-ORG of I-ORG Beijing I-ORG Municipal I-ORG Commission I-ORG of I-ORG Education(KM202010025020 O and O the O Beijing B-ORG Chaoyang I-ORG 1351 I-ORG talent I-ORG training I-ORG program I-ORG No. O CYXX-2017-21 B-AWARD The O funding O organizations O had O no O role O in O the O design O or O conduct O of O this O research O This B-ORG study I-ORG was I-ORG funded I-ORG by I-ORG the I-ORG Army I-ORG Medical I-ORG University I-ORG Excellent I-ORG Youth I-ORG Fund I-ORG XZ-2019-505-054 O Chongqing B-ORG Social I-ORG Science I-ORG Planning I-ORG Youth I-ORG Project I-ORG 2018QNSH42 O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81974138 O The O funding O bodies O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O the O writing O of O the O manuscript O This O research O was O funded O by O Programa O de I-ORG Formación I-ORG de I-ORG Investigadores I-ORG Postdoctorales I-ORG Universidad I-ORG de I-ORG La I-ORG Frontera O grant O number O 2022 O DIUFRO O Universidad I-ORG de I-ORG La I-ORG Frontera O grant O number O DI22-0007 O and O Programa O LANCE I-ORG Universidad I-ORG de I-ORG La I-ORG Frontera O grant O number O Consorcio O Ci2030 O The O work O is O supported O by O the O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31501800 O and O China B-ORG Association I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG Foundation I-ORG for I-ORG Young I-ORG Scholars I-ORG 2015QRNC001 O awarded O to O SW; O and O National O Natural O Science O Foundation O of O China O 31572156 O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-21 O and O the B-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG ASTIP I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG CAAS-ASTIPIVFCAAS O awarded O to O XZ. O The O funding O bodies O had O no O role O in O the O design O of O the O study O the O collection O analysis O and O interpretation O of O data O or O in O writing O the O manuscript O This O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O nos O 81660117 B-AWARD and O 81160087 B-AWARD the O Natural B-ORG Science I-ORG Fund I-ORG of I-ORG Inner I-ORG Mongolia I-ORG Autonomous I-ORG Region I-ORG grant O no. O 2018MS08008 B-AWARD and O the O 2015 B-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Inner I-ORG Mongolia I-ORG Autonomous I-ORG Region I-ORG grant O no. O 201502107 B-AWARD The O funders O had O no O role O in O designing O the O study O in O collecting O analyzing O and O interpreting O the O data O and O in O writing O the O manuscript O This O work O was O supported O by O the O the B-ORG Special I-ORG Project I-ORG of I-ORG the I-ORG Central I-ORG Government I-ORG for I-ORG Guiding I-ORG Local I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2022ZYD0083 O and O the B-ORG Key I-ORG Scientific I-ORG Research I-ORG Fund I-ORG of I-ORG the I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2020YFN0152 O and O the O Open O Fund O of O Qinghai-Tibetan B-ORG Plateau I-ORG Ethnic I-ORG Medicinal I-ORG Resources I-ORG Protection I-ORG and I-ORG Utilization I-ORG Key I-ORG Laboratory I-ORG of I-ORG National I-ORG Ethnic I-ORG Affairs I-ORG Commission I-ORG of I-ORG the I-ORG People’s I-ORG Republic I-ORG of I-ORG China I-ORG QTPEM2201 O This O work O was O financially O supported O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41730753 O 41977049 B-AWARD and O 42077029 B-AWARD the O International O Partnership O Program O of O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG 151432KYSB20200001 O and O International B-ORG Atomic I-ORG Energy I-ORG Agency I-ORG coordinated O research O project O D15020 O This O research O was O supported O by O the O Medical B-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG Province-Ministry O Co-Trained O grant O number O 2015PYA011 B-AWARD the O Public B-ORG Welfare I-ORG Technical I-ORG Applied I-ORG Research I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG grant O number O 2014C33135 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG grant O number O LQ16C080001 B-AWARD the O Medical B-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG China I-ORG grant O number O 2015KYB372 B-AWARD and O the O Public B-ORG Welfare I-ORG Technical I-ORG Applied I-ORG Research I-ORG Project I-ORG of I-ORG Huzhou I-ORG City I-ORG Key O Program O grant O number O 2015GZ14 B-AWARD National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFA0504000 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 91440204 O 81471113 B-AWARD 31770842 B-AWARD Strategic O Priority O Research O Program O of O the O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG XDB19000000 O Youth B-ORG Innovation I-ORG Promotion I-ORG Association I-ORG Chinese O Academy O of O Sciences O Y319S21291 O to O R-J.L O Funding O for O open O access O charge O National O Key O Research O and O Development O Program O of O China O 2017YFA0504000 O National O Natural O Science O Foundation O of O China O 91440204 O 81471113 O 31770842 O Strategic O Priority O Research O Program O of O the O Chinese O Academy O of O Sciences O XDB19000000 O Youth O Innovation O Promotion O Association O Chinese O Academy O of O Sciences O Y319S21291 O to O R-J.L O This O research O was O funded O by O the O Swedish B-ORG Research I-ORG Council O Sweden O CL, O 2014-10171 B-AWARD the O Swedish B-ORG Brain I-ORG Foundation O Sweden O CL, O FO2020-0305 B-AWARD and O FO2021-0412 B-AWARD Bo O and O Ulla O Lundevall O PRIMA O Child O and O Adult O Psychiatry O Sweden O ES O Ekhaga B-ORG Foundation O Sweden O CL, O 2016-47 B-AWARD the B-ORG regional I-ORG agreement I-ORG on I-ORG medical I-ORG training I-ORG and I-ORG clinical I-ORG research I-ORG ALF I-ORG between I-ORG Stockholm I-ORG County I-ORG Council I-ORG and I-ORG Karolinska I-ORG Institutet O Sweden O CL, O SLL20190589 B-AWARD and O the O Lindhés B-ORG Advokatbyrå I-ORG AB I-ORG LY, O LA2019-0013 B-AWARD and O LA2020-0006 B-AWARD None O of O those O listed O here O had O any O part O in O patient O recruitment O data O handling O data O analysis O or O result O interpretation O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81672036 O Youth B-ORG Innovation I-ORG Promotion I-ORG Association I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG 2016302 O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFA0507201 O This O study O was O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG for I-ORG Youth I-ORG BK20180372 O Jiangsu B-ORG Provincial I-ORG Medical I-ORG Youth I-ORG Talent I-ORG QNRC2016812 O and O Key B-ORG Medical I-ORG of I-ORG Jiangsu I-ORG Province I-ORG ZDXKB2016020 O The O funders O had O no O roles O in O study O design O data O collection O data O analysis O and O interpretation O or O writing O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 11804078 B-AWARD the O Postdoctoral B-ORG International I-ORG Exchange I-ORG Program I-ORG of I-ORG China O Grant O No. O YJ20220302 B-AWARD and O the O Australian B-ORG Research I-ORG Council I-ORG ARC O grant O number O DP190100150 B-AWARD This O work O was O supported O by O Beijing B-ORG Agricultural I-ORG Committee I-ORG 20160146 O Tianjin B-ORG Commission I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 15YFXQNC00020 O National B-ORG Dairy I-ORG Industry I-ORG and I-ORG Technology I-ORG System I-ORG CARS-37 O and O Key B-ORG Technologies I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2012BAD12B06 O The O work O was O supported O by O The B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2014A030313004 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Fund I-ORG of I-ORG China I-ORG 2012-81102197 O and O the B-ORG research I-ORG items I-ORG in I-ORG universities I-ORG of I-ORG Guangzhou I-ORG 1201410026 O The O funding O source O has O no O role O in O study O design O in O the O collection O analysis O and O interpretation O of O data O in O the O writing O of O the O report O and O in O the O decision O to O submit O the O article O for O publication O This O work O was O partially O funded O by O the O Special B-ORG Fund I-ORG for I-ORG Basic I-ORG Scientific I-ORG Research I-ORG of I-ORG International I-ORG Center I-ORG for I-ORG Bamboo I-ORG and I-ORG Rattan I-ORG 1632015005 O the O Science B-ORG I-ORG Technology I-ORG Extension I-ORG Project I-ORG of I-ORG State I-ORG Forestry I-ORG Administration I-ORG 2015-04 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31300177 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51902211 O and O 51776131 B-AWARD Liaoning B-ORG Revitalization I-ORG Talents I-ORG Program I-ORG XLYC1802045 O and O the O Foundation B-ORG from I-ORG Liaoning I-ORG Province I-ORG of I-ORG China I-ORG 20170540746 O LJZ2016013 B-AWARD and O lnjc201907 B-AWARD This O study O design O and O data O collection O were O supported O by O two O grants O from O the O Cancer B-ORG Prevention I-ORG and I-ORG Research I-ORG Institute I-ORG of I-ORG Texas I-ORG RP150014 O and O PP140183 B-AWARD The O analysis O data O interpretation O and O writing O were O funded O in O part O by O The O University O of O Texas O Health O Science O Center O at O Houston O School O of O Public O Health O Cancer O Education O and O Career O Development O Program O grant O from O the O National B-ORG Cancer I-ORG Institute I-ORG R25 O CA057712 O and O the O Center O for O Health O Promotion O and O Prevention O Research O During O the O writing O of O the O manuscript O Dr. O Walker O was O also O supported O by O a O research O career O development O award O for O K12HD052023 O Building O Interdisciplinary O Research O Career O in O Women’s O Health O Program-BIRCWH O Berenson O PI) O from O the O Eunice B-ORG Kennedy I-ORG Shriver I-ORG National I-ORG Institute I-ORG of I-ORG Child I-ORG Health I-ORG and I-ORG Human I-ORG Development I-ORG NICHD O at O the O National O Institutes O of O Health O The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O National O Institutes O of O Health O The O funding O bodies O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O is O supported O by O First-class B-ORG Discipline I-ORG Traditional I-ORG Chinese I-ORG Pharmacology I-ORG Construction I-ORG Funding I-ORG of I-ORG Jiangxi I-ORG University I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG No. O JXSYLXK-ZHYAO150 B-AWARD Degree B-ORG and I-ORG Postgraduate I-ORG Education I-ORG Reform I-ORG Project I-ORG of I-ORG Jiangxi I-ORG University I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG No. O jzyjg-2017-10 B-AWARD Jiangxi B-ORG Province I-ORG Humanities I-ORG and I-ORG Social I-ORG Research I-ORG Projects I-ORG of I-ORG University I-ORG No. O YY18212 B-AWARD Education O Reform O Project O of O Jiangxi O University O of O Traditional O Chinese O Medicine O No. O 2018jzqn-2 B-AWARD Academician B-ORG Workstation I-ORG of I-ORG Jiangxi I-ORG University I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG Project I-ORG No. O ysgzz201808 B-AWARD and O Doctoral B-ORG Startup I-ORG Funding I-ORG of I-ORG Jiangxi I-ORG University I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG No. O 2016BS001 B-AWARD All O funders O had O no O role O during O the O entire O process O of O this O study O This O work O was O supported O by O grants O from O the B-ORG University I-ORG Synergy I-ORG Innovation I-ORG Program I-ORG of I-ORG Anhui I-ORG Province I-ORG GXXT-2021-058 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Joint O Fund O Projects O U20A2033 B-AWARD and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Province I-ORG 2108085MC98 O Scientific B-ORG Research I-ORG Project I-ORG of I-ORG higher I-ORG education I-ORG in I-ORG Anhui I-ORG Province I-ORG 2022AH050885 O and O Jiangsu B-ORG Collaborative I-ORG Innovation I-ORG Center I-ORG for I-ORG Modern I-ORG Crop I-ORG Production I-ORG JCIC-MCP O This O research O was O supported O by O Grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21476014 O 31100025 O National B-ORG Science I-ORG I-ORG Technology I-ORG Pillar I-ORG Program I-ORG of I-ORG China I-ORG 2015BAD15B09 O and O Beijing B-ORG Higher I-ORG Education I-ORG Young I-ORG Elite I-ORG Teacher I-ORG Project I-ORG YETP0523 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Approval O no. O 81573167 B-AWARD Science B-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Approval O no. O BE2017657 B-AWARD and O People’s B-ORG livehood I-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG of I-ORG Suzhou I-ORG Approval O no. O SYS201646 B-AWARD and O SYSD2017092 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31860434 O 31972083 B-AWARD the O Inner B-ORG Mongolia I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Project I-ORG 2019MS03051 O and O the O earmarked B-ORG fund I-ORG for O CARS-36 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31972964 O the O Key B-ORG International I-ORG Cooperation I-ORG Project I-ORG of I-ORG Shaanxi I-ORG province I-ORG 2020KWZ-012 O and O Programme B-ORG of I-ORG Introducing I-ORG Talents I-ORG of I-ORG Innovative I-ORG Discipline I-ORG to I-ORG Universities I-ORG Project I-ORG 111 I-ORG from I-ORG the I-ORG State I-ORG Administration I-ORG of I-ORG Foreign I-ORG Experts I-ORG Affairs I-ORG #B18042 O “Crop O breeding O for O disease O resistance O and O genetic O improvement” O The O funding O bodies O have O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O but O just O provide O the O financial O supports O This O work O was O supported O by O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG 973 I-ORG of I-ORG China I-ORG 2012CB722301 O the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 863 I-ORG of I-ORG China I-ORG 2011AA10A203 O the O International B-ORG Cooperation I-ORG Project I-ORG 0102011DFA32610 O and O the O Cooperative B-ORG Innovation I-ORG Center I-ORG of I-ORG Engineering I-ORG and I-ORG New I-ORG Products I-ORG for I-ORG Developmental I-ORG Biology I-ORG of I-ORG Hunan I-ORG Province I-ORG 20134486 O This O work O was O supported O by O the O Science O and O Technology O Project O for O Novel O Coronavirus O Pneumonia O of O Chongqing B-ORG Health I-ORG Committee I-ORG 2020NCPZX01 O the O Science O and O Technology O Project O for O Novel O Coronavirus O Pneumonia O of O Chongqing B-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG CSTC2020jscx-fyzxX0037 O the O COVID-19 O project O from O the O Army B-ORG Medical I-ORG University I-ORG 2020XGBD08 O the O Emergency O Novel O Coronavirus O Pneumonia O Project O from O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of O China O 2020YFC0844700 O and O the O Clinical O Foundation O of O Tongji O Hospital O Tongji B-ORG Medical I-ORG College I-ORG Huazhong I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG XXGZBDYJ010 O This O work O was O supported O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31660412 O Core B-ORG Research I-ORG Budget I-ORG of I-ORG the I-ORG Non-profit I-ORG Governmental I-ORG Research I-ORG Institution I-ORG 1630032016008 O Funds B-ORG of I-ORG the I-ORG modern I-ORG agricultural I-ORG industry I-ORG technology I-ORG system I-ORG CARS-HNCYH O and O the O Comprehensive B-ORG Strength I-ORG Promotion I-ORG Plan I-ORG of I-ORG College I-ORG in I-ORG the I-ORG Western I-ORG Regions I-ORG M8K3124001001003002 O This O study O was O supported O by O The B-ORG Netherlands I-ORG Heart I-ORG Foundation I-ORG NHS O 98.113 B-AWARD the O Dutch B-ORG Cancer I-ORG Foundation I-ORG RUL O 99/1992 O and O The B-ORG Netherlands I-ORG Organization I-ORG for I-ORG Scientific I-ORG Research I-ORG 912-03-033 O 2003 O The O study O was O funded O by O Grand B-ORG Challenges I-ORG Canada I-ORG Grant O number I-AWARD S5 I-AWARD 0440-01 O FOO O was O also O supported O by O Wellcome B-ORG Trust I-ORG Intermediate I-ORG Fellowship I-ORG in I-ORG Public I-ORG Health I-ORG and I-ORG Tropical I-ORG Medicine I-ORG Grant O number I-AWARD WT102350/Z/13/Z O ASM O is O also O supported O by B-ORG Wellcome I-ORG Trust I-ORG Masters I-ORG Fellowship I-ORG Grant O number I-AWARD WT106356/Z/14/Z O Support O for O this O study O came O from O grants O from O the O National B-ORG Eye I-ORG Institute I-ORG EY011930 O EY019015 B-AWARD and O EY010608-139005 B-AWARD to O W.H.K O EY07551 B-AWARD to O L.J.F O and O EY024376 B-AWARD to O C.-A.M O from O the O Robert O A. O Welch B-ORG Foundation I-ORG G-0010 O to O W.H.K O from O a O National B-ORG Cancer I-ORG Institute I-ORG Cancer O Center O Support O Grant O CA016672 O to O the O MD O Anderson O Cancer O Center O Ronald O DePinho O PI) O and O from O Velux B-ORG Foundation I-ORG 695 O to O C.A O The O SIREN O project O is O supported/funded O by O U54HG007479 B-AWARD from O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH O as O part O of O the O H3Africa O Consortium,https://h3africa.org/consortium/projects O All O authors O except O for O Shelia O Johnson O received O funding O through O the O grant O Support O for O the O development O of O the O database O for O capturing O the O data O was O supported O by O the O South O Carolina O Translational O Research O Institute O supported O by O the O NIH B-ORG National I-ORG Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences I-ORG NCATS I-ORG through O Grant O Number O UL1 B-AWARD TR001450,https://ncats.nih.gov/about/overview,http://academicdepartments.musc.edu/sctr O Carolyn O Jenkins O received O support O from O South O Carolina O Translational O Research O Institute O for O the O development O of O that O SIREN O qualitative O database O Shelia O Johnson O was O supported O by O a O Post-baccalureate O Research O Education O Training O grant O from O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG of I-ORG the I-ORG National I-ORG Institutes I-ORG of I-ORG Health I-ORG under O award O number O R25GM113278 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 51675153 B-AWARD Major B-ORG Science I-ORG and I-ORG Technology I-ORG Special I-ORG Project I-ORG in I-ORG Anhui I-ORG Grant O No. O 17030901084 B-AWARD Anhui B-ORG Province I-ORG University I-ORG Natural I-ORG Science I-ORG Research I-ORG Project I-ORG Grant O No. O KJ2017A447 B-AWARD and I-AWARD KJ2019A0678 O and O School-level O Scientific O Research O Projects O of O Chaohu O University O Grant O No. O XLZ-201907 B-AWARD This O work O was O supported O by O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG of I-ORG Guangzhou I-ORG City O China O 201607020006 O funding O from O State B-ORG Key I-ORG Laboratory I-ORG for I-ORG Conservation I-ORG and I-ORG Utilization I-ORG of I-ORG Subtropical I-ORG Agro-bioresources I-ORG SKLCUSA-b201714 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31770256 O 31600193 B-AWARD and O the O Graduate B-ORG Student I-ORG Overseas I-ORG Study I-ORG Program I-ORG from I-ORG South I-ORG China I-ORG Agricultural I-ORG University I-ORG 2017LHPY010 O We O are O grateful O to O Medical B-ORG Research I-ORG Council I-ORG MRC O #MR/S035826/1 O and O Biotechnology B-ORG and I-ORG Biosciences I-ORG Research I-ORG Council I-ORG BBSRC O #BB/T004460/1 O UK O for O funding O this O work O The O human O embryonic O and O fetal O material O was O provided O by O the O joint O MRC/Wellcome O Trust I-ORG Human I-ORG Developmental I-ORG Biology I-ORG Resource I-ORG #MR/R006237/1 O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2021YFE0111100 O Science B-ORG and I-ORG Technology I-ORG Partnership I-ORG Program I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG KY202201002 O Jiangsu B-ORG Provincial I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG BZ2022017 O China B-ORG National I-ORG Textile I-ORG and I-ORG Apparel I-ORG Council I-ORG J202002 O Jiangsu B-ORG Advanced I-ORG Textile I-ORG Engineering I-ORG Technology I-ORG Center I-ORG XJFZ/2021/7 O This O research O was O supported O by O the O Core B-ORG Research I-ORG for I-ORG Evolutional I-ORG Science I-ORG and I-ORG Technology I-ORG CREST O program O JPMJCR13W3 O from O the O Japan O Science O and O Technology O Agency O JST O by O Japan B-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG JSPS O KAKENHI O Grant O Number O JP16K20975 B-AWARD by O JSPS O Grant-in-Aid O for O JSPS O Research O Fellow O Grant O Number O JP18J21761 B-AWARD and O by O Japan B-ORG Agency I-ORG for I-ORG Medical I-ORG Research I-ORG and I-ORG Development I-ORG AMED O under O Grant O Number O JP18gm1110007h0001 B-AWARD This O research O was O supported O financially O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG China I-ORG No. O 2017YFD0502004 O National B-ORG key I-ORG research I-ORG and I-ORG development I-ORG program I-ORG No. O 2018YFD0501003 O Hubei O Provincial O Creative O Team O Project O of O Agricultural O Science O and O Technology O No. O 2007-620 O and O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG No. O CARS-36 O The O study O was O supported O by O the O project O POWR.03.02.00-00-I014/17-00 B-AWARD co-financed O by O the O European B-ORG Union I-ORG through O the O European O Social O Fund O under O the O Operational O Programme O Knowledge O Education O Development O 2014–2020 O Publication O of O the O article O was O also O supported O by O the O project O POWR.03.02.00-00-I014/17-00 O co-financed O by O the O European O Union O through O the O European O Social O Fund O under O the O Operational O Programme O Knowledge O Education O Development O 2014–2020 O This O research O was O funded O by O the O Polish B-ORG Ministry I-ORG of I-ORG Education I-ORG and I-ORG Science I-ORG for I-ORG the I-ORG Medical I-ORG University I-ORG of I-ORG Gdansk I-ORG intended I-ORG for I-ORG Young I-ORG Scientists O grant O number O 01-50022/643-0003381 B-AWARD This O work O was O also O supported O by O the O “Experienced O Researcher” O MUG O program O no O 71-01415/0004593/61/524/524/2022 B-AWARD to O M.J O Financial O support O was O provided O by O The O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG no. O 2016YFD0401104 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 31871838 B-AWARD and O Support B-ORG Project I-ORG of I-ORG High-level I-ORG Teachers I-ORG in I-ORG Beijing I-ORG Municipal I-ORG Universities I-ORG no. O IDHT20180506 B-AWARD This O study O was O supported O by O research O grants O from O the O ‘Instituto O de I-ORG Salud I-ORG Carlos I-ORG III’ O ISCIII O Spanish O Ministry O of O Economy O and O Competitiveness O PI10/00967 O and O CP11/00021 O to O MM O the O R. B-ORG Barri I-ORG Private I-ORG Foundation I-ORG PV12142S O to O MM O the O Medical B-ORG Research I-ORG Council I-ORG G0701446 O to O SS O and O National B-ORG Institutes I-ORG of I-ORG Health I-ORG Grant I-ORG GM028140 O to O GMC O CIBER O de O Diabetes O y O Enfermedades O Metabólicas O asociadas O CB07708/0012 O is O an O initiative O of O the O ISCIII O MM O acknowledges O support O from O the O ‘Miguel O Servet’ O tenure O track O programme O CP11/00021 O from O the O Fondo O de O Investigación O Sanitaria O FIS O co-financed O by O the O European O Regional O Development O Fund O ERDF O and O supported O by O a O Salvador O de O Madariaga O Mobility O fellowship O from O the O Spanish B-ORG Ministry I-ORG of I-ORG Education I-ORG PR2011-0584 O AT O is O the O recipient O of O a O FI-DGR O fellowship O 9015-97318/2012 O from O the O Agència B-ORG de I-ORG Gestió I-ORG d’Ajuts I-ORG Universitaris I-ORG i I-ORG de I-ORG Recerca I-ORG AGAUR O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2019YFC0840607 O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG China I-ORG 2017ZX09304010 O Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG action I-ORG medical I-ORG key I-ORG Program I-ORG 1341195400 O The O grants O had O no O role O in O the O design O or O conduct O of O this O research O This O study O is O supported O by O grants O from O the O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG of I-ORG Guangdong I-ORG Province I-ORG grant O number O 2013B021800141 B-AWARD http://pro.gdstc.gov.cn/egrantweb/proposal/prp-edit-list?year=&stat_year=&is_lazy_load_data_info=false## O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG grant O number O 2014Y2-00179 B-AWARD http://www.gzsi.gov.cn O and O Science B-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG of I-ORG International I-ORG Cooperation I-ORG of I-ORG Guangdong I-ORG Province I-ORG grant O number O 2016A050502011 B-AWARD http://www.gdstc.gov.cn O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O authors’ O work O cited O in O this O review O was O supported O in O part O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81400725 O to O W.S O 81700635 B-AWARD to O Y.C O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jilin I-ORG Province I-ORG 20160101030JC O to O W.S O the O 13th B-ORG Five-Year I-ORG scientific I-ORG research I-ORG planning I-ORG program I-ORG of I-ORG Jilin I-ORG province I-ORG JJKH20180210KJ O to O W.S O the O National B-ORG Postdoctoral I-ORG Program I-ORG for I-ORG Innovative I-ORG Talents I-ORG BX201700098 O to O Y.C O and O the O Postdoctoral B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 2017M621216 O to O Y.C O This O research O was O funded O by O Ministry B-ORG of I-ORG Health I-ORG of I-ORG the I-ORG Czech I-ORG Republic O grant O nr. O NV18-03-00339 B-AWARD This O research O was O supported O by O the O project O National B-ORG Institute I-ORG for I-ORG Cancer I-ORG Research I-ORG Programme O EXCELES O ID O Project O No. O LX22NPO5102)—Funded B-AWARD by O the O European B-ORG Union—Next I-ORG Generation I-ORG EU, O by O MH O CZ—DRO O MMCI O 00209805 B-AWARD and O by O the O project O BBMRI.CZ O no. O LM2023033 B-AWARD This O work O was O financially O supported O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2018YFD0900400 B-AWARD the O Da B-ORG Bei I-ORG Nong I-ORG Group I-ORG Promoted I-ORG Project I-ORG for I-ORG Young I-ORG Scholar I-ORG of I-ORG HZAU I-ORG No. O 2017DBN014 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31602131 B-AWARD This O research O was O funded O by O the O “Pioneer” B-ORG and I-ORG “Leading I-ORG Goose” I-ORG R&D I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Grant O No. O 2022C01046 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O No. O 12205288 B-AWARD 12275262 B-AWARD 11975220 B-AWARD 51972291 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG No. O LGG22E020001 B-AWARD Z23E020002 B-AWARD Q23A050005 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Provincial I-ORG Universities I-ORG of I-ORG Zhejiang I-ORG No. O 2021YW14 B-AWARD This O work O was O supported O by O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Tianjin I-ORG Universities O 2017KDZD02 B-AWARD to O PhD O Tao O Wu; O Innovation B-ORG of I-ORG modern I-ORG Agricultural I-ORG Project O F17RO2 B-AWARD Pro O Min O Zhang O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China O 2017YFD0400106 B-AWARD Pro O Min O Zhang O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31672231 O and O the B-ORG earmarked I-ORG fund I-ORG for I-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-12 O Publication O costs O of O the O article O were O covered O by O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2662016PY117 O The O funders O have O no O role O in O the O study O design O data O analysis O and O interpretation O and O manuscript O writing O but O just O provide O the O financial O support O Funding O provided O by O the O Innovative B-ORG Team I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG no. O 2013TD12 B-AWARD Chengran O Fang O International B-ORG Science I-ORG and I-ORG Technology I-ORG Cooperation I-ORG Program I-ORG of I-ORG China I-ORG no. O 2014DFE90040 B-AWARD Chengran O Fang O and O Significant B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG no. O 2015C33006 B-AWARD Chengran O Fang O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 21506096 B-AWARD and O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2013AA020302 O Key B-ORG Laboratory I-ORG of I-ORG Agro-Products I-ORG Processing I-ORG Ministry I-ORG of I-ORG Agriculture I-ORG 2015011 O the B-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Bio-organic I-ORG and I-ORG Natural I-ORG Products I-ORG Chemistry I-ORG CAS I-ORG SKLBNPC15429 O and O the B-ORG Six I-ORG Talent I-ORG Peaks I-ORG Project I-ORG in I-ORG Jiangsu I-ORG Province I-ORG 2015-JY-009 O This O funding O was O mainly O used O in O the O study O design O date O analysis O and O decision O to O publish O This O research O was O funded O by O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG People’s I-ORG Republic I-ORG of I-ORG China I-ORG Grant O number O 2020YFC1908603 B-AWARD Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Committee I-ORG Grant O number O 21YF1449100 B-AWARD 21230714500 B-AWARD and O Tongji B-ORG University I-ORG Grant O number O 22120210533 B-AWARD 2022-4-YB-11 B-AWARD Funding O for O the O Survey O of O the O Health O of O Wisconsin O SHOW O was O provided O by O theWisconsin O Partnership I-ORG ProgramPERC O Award O 233 O PRJ I-AWARD 25DJ O the O National O Institutes O of O Health'sClinical O and I-ORG Translational I-ORG ScienceAward O 5UL O RR025011 O and O theNational O Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute(1 O RC2 I-AWARD HL101468 O The O authors O acknowledge O the O funding O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O Grant O NO. O 51825203 B-AWARD and O NO. O 52208232 B-AWARD State B-ORG Key I-ORG Laboratory I-ORG of I-ORG High-Performance I-ORG Civil I-ORG Engineering I-ORG Materials I-ORG Open I-ORG Fund I-ORG Grant O NO. O 2021CEM002 B-AWARD Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG 2025 I-ORG Major I-ORG Project I-ORG of I-ORG Ningbo I-ORG 2020Z040 O and O Jiangsu B-ORG Provincial I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Support I-ORG Program I-ORG No. O BZ2022036 B-AWARD This O work O was O supported O by O 1) O Government B-ORG of I-ORG the I-ORG Autonomous I-ORG Community I-ORG of I-ORG the I-ORG Basque I-ORG Country O Grant O Number O SAF2014-52097R B-AWARD Recipient O OM),https://www.euskadi.eus/r48-bopv2/es/bopv2/datos/2014/03/1401207a.pdf O 2) O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG MINECO O Grant O Number O CTQ2012-32183/BQU B-AWARD Recipient O OM),http://www.idi.mineco.gob.es/stfls/eSede/Ficheros/2012/Anexo137_Investigacion_quimica_basica_Preseleccionados.pdf O and O 3) O National B-ORG Institutes I-ORG of I-ORG Health O Grant O Number O 2R01AT001576-11A1 B-AWARD Recipient O JMM),http://report.nih.gov/categorical_spending_project_listing.aspx?FY=2014&ARRA=N&DCat=Liver%20Cancer O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O NO. O 81471171 B-AWARD 81771194 B-AWARD Shengmei O Zhu O Zhejiang B-ORG Medical I-ORG Technology I-ORG I-ORG Education I-ORG 2014KYA088,2017KY323 O the B-ORG Project I-ORG of I-ORG Experimental I-ORG Animal I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG of I-ORG Zhejiang I-ORG Province I-ORG NO.2018C37116 O Yueying O Zheng O Open O access O funding O provided O by O University O of O Jyväskylä O JYU O This O work O was O supported O by O the O Science O Project O of O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG No. O 15dz1208103 B-AWARD Academy B-ORG of I-ORG Finland I-ORG Grant O No. O 295709 B-AWARD and O Taishan B-ORG Scholar I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG No. O tsqn201909126 B-AWARD This O work O was O supported O by O the O Comisión B-ORG de I-ORG Ciencia I-ORG y I-ORG Tecnologia I-ORG de I-ORG Chile I-ORG CONICYT/FONDECYT/INACH/INICIACION/#11150129 O and O the O EU B-ORG Marie I-ORG Curie I-ORG IRSES I-ORG Project I-ORG DEANN I-ORG PIRSES-GA-2013-612583 O Eduardo O Hajdu O received O support O from O the O National B-ORG Council I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Development I-ORG grant O CNPq O 476558/2012–3 O and O the O Carlos B-ORG Chagas I-ORG Filho I-ORG Research I-ORG Support I-ORG Foundation I-ORG of I-ORG Rio I-ORG de I-ORG Janeiro I-ORG State I-ORG FAPERJ O E–26/102.292/2013 O Maja O Malmberg O received O financial O support O from O the O Swedish B-ORG Research I-ORG Council I-ORG for I-ORG Environment I-ORG Agricultural I-ORG Sciences I-ORG and I-ORG Spatial I-ORG Planning I-ORG Formas I-ORG Grant O Number O 221-2012-586 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81922048 O 81902684 I-AWARD 81572583 I-AWARD 81874113 I-AWARD 81874112 I-AWARD 81502278 I-AWARD 81372848 I-AWARD 81370075 I-AWARD 81530075 I-AWARD 81773155 I-AWARD 81672600 I-AWARD and I-AWARD 81722032 O the O Municipal B-ORG Project I-ORG for I-ORG Developing I-ORG Emerging I-ORG and I-ORG Frontier I-ORG Technology I-ORG in I-ORG Shanghai I-ORG Hospitals I-ORG SHDC12010116 O the O Cooperation B-ORG Project I-ORG of I-ORG Conquering I-ORG Major I-ORG Diseases I-ORG in I-ORG the I-ORG Shanghai I-ORG Municipality I-ORG Health I-ORG System I-ORG 2013ZYJB0302 O the O Innovation B-ORG Team I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG IRT1223 O the O Shanghai B-ORG Key I-ORG Laboratory I-ORG of I-ORG Breast I-ORG Cancer I-ORG 12DZ2260100 O the O Training B-ORG Plan I-ORG of I-ORG Excellent I-ORG Talents I-ORG in I-ORG Shanghai I-ORG Municipality I-ORG Health I-ORG System I-ORG 2017YQ038 O the O “Chen B-ORG Guang” I-ORG project I-ORG supported I-ORG by I-ORG the I-ORG Shanghai I-ORG Municipal I-ORG Education I-ORG Commission I-ORG and I-ORG Shanghai I-ORG Education I-ORG Development I-ORG Foundation I-ORG 17CG01 O the O Shanghai B-ORG Pujiang I-ORG Program I-ORG 18PJD007 O the O Training B-ORG Plan I-ORG of I-ORG Excellent I-ORG Talents I-ORG of I-ORG FUSCC I-ORG YJYQ201602 O the O Fok B-ORG Ying-Tong I-ORG Education I-ORG Foundation I-ORG for I-ORG College I-ORG Young I-ORG Teachers I-ORG 171034 O and O National O Key O Research O and O Development O Program O of O China O 2017YFC0108904 O The O study O was O financed O by O the O following O funding O bodies O Institut O national O de O la O santé O et O de O la O recherche O médicale O Inserm O Sorbonne B-ORG Universite I-ORG Emergence I-ORG MycELIA O SU-16-R-EMR-45 O Agence B-ORG Nationale I-ORG de I-ORG la I-ORG Recherche I-ORG MetAntibody O ANR-14-CE14-0013 O and O HDHL-Intimic B-ORG Era-Net I-ORG EarlyFOOD O This O work O was O supported O in O part O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31860016 O 32160045 B-AWARD the B-ORG key I-ORG Project I-ORG of I-ORG Yunnan I-ORG Applied I-ORG Basic I-ORG Research I-ORG 202201AS070052 O and O grants O from O the O Young B-ORG Academic I-ORG and I-ORG Technical I-ORG Leader I-ORG Raising I-ORG Foundation I-ORG of I-ORG Yunnan I-ORG Province I-ORG to I-ORG Lian-Ming I-ORG Liang I-ORG and I-ORG the I-ORG Ten-thousand I-ORG Talents I-ORG Plans I-ORG for I-ORG Young I-ORG Top-notch I-ORG Talents I-ORG of I-ORG Yunnan I-ORG Province I-ORG YNWR-QNBJ-2018-135 O This O research O was O supported O by O the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 863 O Program O 2013AA102803 B-AWARD the O National B-ORG Science I-ORG Fund I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG no. O 31225026 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 31372345 B-AWARD This O work O was O supported O by O the O Peking B-ORG University’s I-ORG 985 B-AWARD Grants O Open B-ORG Project I-ORG of I-ORG Key I-ORG Laboratory I-ORG of I-ORG Regenerative I-ORG Biology I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG KLRB201401 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 813716977 B-AWARD 81570944 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O is O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 51402198 I-AWARD 21671139 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province I-ORG 201602592 O 20170540715 O Educational O Bureau O of O Liaoning O Province O for O the O Fundamental B-ORG Research I-ORG of I-ORG Key I-ORG Lab I-ORG grant O no. O LZ2014028 B-AWARD LZ2016003 O the O talent O scientific O research/scientific O research O cultivation O fund O of O LSHU B-ORG no. O 2015XJJ-009/2016PY-003 B-AWARD This O research O was O funded O by O the O GDAS’ B-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Development O grant O numbers O 2020GDASYL-2020103123 B-AWARD 2022GDASZH-2022010109 B-AWARD 2021GDASYL-20210302008 B-AWARD and O 2020GDASYL-20200301001 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China O grant O number O no. O 2020YFE0205300 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province O grant O number O 2022B1212050001 B-AWARD This O study O was O supported O by O ANPCyT–FONCyT B-ORG grant O PICT-2016-0410 B-AWARD to O Julio O Villena O This O study O was O also O supported O by O Grant-in-Aid B-ORG for I-ORG Scientific I-ORG Research I-ORG A) O 19H00965 O from O the O Japan O Society O for O the O Promotion O of O Science O JSPS O and O by O the O Japan B-ORG Racing I-ORG Association O and O the O research O program O on O the O development O of O innovative O technology O grants O JPJ007097 O from O the O Project O of O the O Bio-oriented O Technology O Research O Advancement O Institution O BRAIN O to O Haruki O Kitazawa O and O by O the O JSPS O Core-to-Core O Program O A. O Advanced O Research O Networks O entitled O the O establishment O of O international O agricultural O immunology O research-core O for O a O quantum O improvement O in O food O safety O and O by O AMED B-ORG Grant O Number O JP21zf0127001 B-AWARD Kohtaro O Fukuyama O was O supported O by O JST B-ORG the I-ORG establishment I-ORG of I-ORG university I-ORG fellowships I-ORG toward I-ORG the I-ORG creation I-ORG of I-ORG science I-ORG technology I-ORG innovation O grant O number O JPMJFS2102 B-AWARD SD O is O funded O by O an O NHMRC B-ORG Project I-ORG Grant I-ORG 1100394 O and O an O ARC B-ORG Discovery I-ORG Project I-ORG DP170103076 O RNP O is O a O Wellcome B-ORG Trust I-ORG Senior I-ORG Fellow I-ORG in I-ORG Clinical I-ORG Science I-ORG 200909 O JAS O is O funded O by O an O Australian B-ORG NHMRC I-ORG Senior I-ORG Research I-ORG Fellowship I-ORG 1104975 B-AWARD This O work O is O supported O in O part O by O the O Australian B-ORG Centre I-ORG for I-ORG Research I-ORG Excellence I-ORG in I-ORG Malaria I-ORG Elimination O funded O by O the O NHMRC O 1134989 O This O work O was O supported O on O the O Chinese O side O by O a O project O of O International B-ORG Scientific I-ORG and I-ORG Technical I-ORG Cooperation I-ORG 2013DFG31930 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No.31201477 O and O Special O Fund O for O Agro-scientific B-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG 201303016 O Balázs O Brankovics O was O supported O by O the O Division B-ORG for I-ORG Earth I-ORG and I-ORG Life I-ORG Sciences I-ORG ALW I-ORG with I-ORG financial I-ORG aid I-ORG from I-ORG the I-ORG Netherlands I-ORG Organization I-ORG for I-ORG Scientific I-ORG Research I-ORG NWO I-ORG Dossier O 833.13.006 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O National B-ORG Found I-ORG for I-ORG Fostering I-ORG Talents I-ORG of I-ORG Basic I-ORG Science I-ORG J1103605/J0108 O from O National O Natural O Science O Foundation O of O China O Peking B-ORG University I-ORG Health I-ORG Science I-ORG Center I-ORG 2017 I-ORG Medical I-ORG Education I-ORG Research I-ORG Project I-ORG 2017JJ10 O Chinese B-ORG Medical I-ORG Association I-ORG Medical I-ORG Education I-ORG Branch I-ORG and I-ORG China I-ORG Higher I-ORG Education I-ORG Society I-ORG Medical I-ORG Education I-ORG Specialized I-ORG Committee I-ORG 2016 I-ORG Medical I-ORG Education I-ORG Research I-ORG Project I-ORG 2016B-RC021 O This O research O was O supported O by O the O Fund B-ORG for I-ORG Outstanding I-ORG Young I-ORG Scholars I-ORG from I-ORG Henan I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG Grant O No. O 2022YQ05 B-AWARD Innovation B-ORG and I-ORG Creativity I-ORG Project I-ORG of I-ORG Henan I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG Grant O No. O 2020CX23 B-AWARD and O the O Major B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Henan I-ORG Province I-ORG Grant O No. O 201300111000 B-AWARD This O study O was O supported O by O a O Healthcare B-ORG Research I-ORG Project I-ORG China I-ORG PLA I-ORG grant O number O 13BJZ46 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 51471186 B-AWARD and O Beijing B-ORG Hope I-ORG Run I-ORG Special I-ORG Fund I-ORG of I-ORG Cancer I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O LC2012B26 B-AWARD and I-AWARD 2015A03 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 21375107 B-AWARD Key B-ORG scientific I-ORG research I-ORG project I-ORG of I-ORG Henan I-ORG Higher I-ORG Education I-ORG Institutions I-ORG No. O 22B180008 B-AWARD O No. O 22A180023 B-AWARD National B-ORG Scientific I-ORG Research I-ORG Project I-ORG Cultivation I-ORG Fund I-ORG project I-ORG of I-ORG huang-huai I-ORG University I-ORG No. O 110721331001 B-AWARD O No. O XKPY-2022001 B-AWARD Key B-ORG Science I-ORG I-ORG Technology I-ORG Specific I-ORG Projects I-ORG of I-ORG Henan I-ORG Province I-ORG No. O 191110110600 B-AWARD Key O Science O and O Technology O Innovation O Project O of O Zhumadian O City O No. O 17702 O Key O Specialized O Research O and O Development O Breakthrough O of O Henan O Province O No. O 232102320321 O This O work O was O supported O by O the O Sichuan B-ORG International I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Cooperation/Hong I-ORG Kong I-ORG Macao I-ORG and I-ORG Taiwan I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Cooperation I-ORG Project O Sichuan O China O grant O no. O 2019YFH0065 B-AWARD Key B-ORG Open I-ORG Laboratory I-ORG of I-ORG Conservation I-ORG Biology I-ORG of I-ORG Rare I-ORG Animals I-ORG in I-ORG Giant I-ORG Panda I-ORG National I-ORG Park I-ORG State I-ORG Forestry I-ORG and I-ORG Grassland I-ORG Administration I-ORG no. O KLSFGAGP2020.014 B-AWARD and O the O High-level B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG for I-ORG the I-ORG Introduction I-ORG of I-ORG Talents I-ORG of I-ORG Sichuan I-ORG Agricultural I-ORG University I-ORG no. O 03120322 B-AWARD The O funders O had O no O role O in O design O decision O to O publish O or O preparation O of O the O manuscript O This O project O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O No. B-AWARD 31372375 O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG JiangSu I-ORG Province I-ORG BK20131240 O and O the B-ORG Project I-ORG of I-ORG the I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Silkworm I-ORG Genome I-ORG Biology I-ORG sklsgb2013020 O This O work O was O funded O by O LUPUS O UK, O The O Rosetrees O Trust O and O Arthritis B-ORG Research I-ORG UK I-ORG Programme O Grant O 19423 B-AWARD and O was O supported O by O the O National O Institute O for O Health O Research O NIHR O University O College O London O Hospitals O Biomedical O Research O Centre O Drs O Ioannou O and O Isenberg O are O also O supported O by O Arthritis O Research O UK O Grant O 20164 B-AWARD Dr. O Hanly’s O work O was O supported O by O the O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG research O grant O MOP-86526 B-AWARD Dr. O Sang-Cheol O Bae’s O work O was O in O part O by O unrestricted O grant O Hanyang O University O 201600000001387 O Dr. O Caroline O Gordon’s O work O was O supported O by O Lupus O UK, O Sandwell O and O West O Birmingham O Hospitals O National O Health O Service O NHS O Trust O and O the O NIHR/Wellcome O Trust O Clinical O Research O Facility O in O Birmingham O Dr O Petri O and O the O Hopkins O Lupus O Cohort O are O supported O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH O grant O AR43727 O The O Montreal O General O Hospital O Lupus O Clinic O is O partially O supported O by O the O Singer O Family O Fund O for O Lupus O Research O Dr. O Clarke O holds O The O Arthritis O Society O Chair O in O Rheumatic O Diseases O at O the O University O of O Calgary O Dr. O Paul O R. O Fortin O presently O holds O a O tier O 1 O Canada O Research O Chair O on O Systemic O Autoimmune O Rheumatic O Diseases O at O Université O Laval O and O part O of O this O work O was O done O while O he O was O still O holding O a O Distinguished O Senior O Investigator O of O The O Arthritis O Society O Dr. O Bruce O is O an O NIHR O Senior O Investigator O and O is O funded O by O Arthritis O Research O UK, O the O National O Institute O for O Health O Research O Manchester O Biomedical O Research O Unit O and O the O NIHR/Wellcome O Trust O Manchester O Clinical O Research O Facility O The O views O expressed O in O this O publication O are O those O of O the O author(s O and O not O necessarily O those O of O the O NHS O the O NIHR O or O the O Department O of O Health O Dr. O Soren O Jacobsen O is O supported O by O the O Danish O Rheumatism O Association O A1028 O and O the O Novo O Nordisk O Foundation O A05990 O Dr. O Ramsey-Goldman’s O work O was O supported O by O the O NIH O grants O 1U54TR001353 O formerly O 8UL1TR000150 O and O UL-1RR-025741 O K24-AR-02318 O and O P60AR064464 B-AWARD formerly O P60-AR-48098 O Dr. O Mary O Anne O Dooley’s O work O was O supported O by O the O NIH O grant O RR00046 B-AWARD Dr. O Ruiz-Irastorza O is O supported O by O the O Department O of O Education O Universities O and O Research O of O the O Basque O Government O None O of O these O funding O bodies O played O any O role O in O the O design O of O the O study O collection O analysis O or O interpretation O of O the O data O We O thank O the O financial O support O from O the B-ORG special I-ORG project I-ORG of I-ORG basic I-ORG work I-ORG for I-ORG science I-ORG and I-ORG technology I-ORG 2014FY120900 O the O key O project O of O the B-ORG basic I-ORG research I-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG 12JC1404600 O and O the O special O fund O of O modern B-ORG agricultural I-ORG industry I-ORG technology I-ORG system I-ORG CARS-02 O This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFA0504304 O and O 2016YFA0502204 B-AWARD to O Y.P O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81772960 O and O 81572739 B-AWARD to O Y.P O and O Graduate B-ORG Student’s I-ORG Research I-ORG and I-ORG Innovation I-ORG Fund I-ORG of I-ORG Sichuan I-ORG University I-ORG 2018YJSY017 O to O D.S O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O Nos O 81600128 B-AWARD and O 31501146 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG grant O Nos O BS2015SW024 B-AWARD and O BS2015YY013 B-AWARD intramural O Scientific B-ORG Research I-ORG Foundation I-ORG from I-ORG Binzhou I-ORG Medical I-ORG University I-ORG grant O Nos O BY2014KYQD21 B-AWARD and O BY2014KYQD22 B-AWARD Medical O and O Health O Technology O of O Shandong O China O 2016WS0007 O and O the O Dominant O Disciplines’ O Talent O Team O Development O Scheme O of O Higher O Education O of O Shandong O Province O 2016052410 O This O research O was O funded O by O the O Biodiversity O Survey O and O Assessment O Project O of O the O Ministry B-ORG of I-ORG Ecology I-ORG and I-ORG Environment O China O #2019HJ2096001006 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG #31600253 O and O the O China B-ORG Scholarship I-ORG Council I-ORG 201708515018 O This O work O was O supported O by O the O Research B-ORG Council I-ORG of I-ORG Norway I-ORG Oslo I-ORG Norway I-ORG 213837 O 223273 B-AWARD 217776 B-AWARD the O South-East B-ORG Norway I-ORG Regional I-ORG Health I-ORG Authority I-ORG Hamar I-ORG Norway I-ORG 2013-123 O and O the O KG B-ORG Jebsen I-ORG Foundation I-ORG Bergen I-ORG Norway I-ORG Grant O No. O SKGJ-2011-36 B-AWARD None O of O these O funding O sources O played O a O role O in O the O design O of O the O study O or O in O the O collection O analysis O and O interpretation O of O data O or O in O writing O the O manuscript O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31301319 B-AWARD the O Foundation B-ORG of I-ORG Science I-ORG I-ORG Technology I-ORG Department I-ORG of I-ORG Sichuan I-ORG Province O China O Grant O No. O 16JC0022 B-AWARD and O the O project B-ORG of I-ORG Youth I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Team I-ORG of I-ORG Sichuan I-ORG Province O China O Grant O No. O 2017TD0008 B-AWARD In O all O cases O the O funding O body O played O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O Preparation O of O this O manuscript O was O supported O by O theU O S. I-ORG Department I-ORG of I-ORG Education I-ORG Office I-ORG of I-ORG Innovation(U411B110098),10.13039/100000071National O Institute I-ORG of I-ORG Child I-ORG Health I-ORG and I-ORG Human I-ORG Development(No O HD034294 B-AWARD and O the10.13039/100000865Bill O I-ORG Melinda I-ORG Gates I-ORG Foundation(No O OPP1173152 B-AWARD The O funders O had O no O role O in O the O manuscript O preparation O and O decision O to O submit O for O publication O This O work O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51905501 O This O work O is O also O supported O by O the O Tangshan B-ORG Talent I-ORG Foundation I-ORG Innovation I-ORG Team I-ORG 20130204D O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Hebei I-ORG Education I-ORG Department I-ORG QN2021117 O and O S&P B-ORG Program I-ORG of I-ORG Hebei I-ORG Grant O No. O 22281802Z B-AWARD This O work O was O supported O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG grant O numbers O 2R01DC006471 B-AWARD 1R01DC015010 B-AWARD R01DC015444 B-AWARD 1R21DC013879 B-AWARD and O P30CA21765 B-AWARD ALSAC O the O Office B-ORG of I-ORG Naval I-ORG Research I-ORG grant O numbers O N000140911014 B-AWARD N000141210191 B-AWARD N000141210775 B-AWARD and O N000141612315 B-AWARD and O The O Hartwell B-ORG Foundation I-ORG Individual O Biomedical I-AWARD Research I-AWARD Award O This O work O was O supported O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG R01DK109398 O and O R01DK131049 B-AWARD to O R.C.A O Lowe B-ORG Syndrome I-ORG Association I-ORG Lowe I-ORG Syndrome I-ORG Trust I-ORG and I-ORG the I-ORG Clinical I-ORG and I-ORG Translational I-ORG Science I-ORG Institute I-ORG CTSI O 106564/8000063783 I-AWARD PDT O grants O to O R.C.A O J.J.L O G.B O and O C.C O are O supported O by O RCA’s O R01DK131049 O C.C O was O also O partially O supported O by O NIGMS-funded B-ORG predoctoral O fellowship O provided O by O T32 B-AWARD GM132024 I-AWARD The O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 32171861 B-AWARD 32272749 B-AWARD 32002076 B-AWARD 31972454 B-AWARD the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG grant O number O 2018YFD1000400 B-AWARD the O Jiangsu B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG grant O number O SBK2020043530 B-AWARD This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31402066 O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG 2018YFD0501504 O the B-ORG Research I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Basic I-ORG Public I-ORG Welfare I-ORG LGN18C170003 O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG LQ17C170003 O and O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31702106 O 31572385 B-AWARD These O funding O bodies O played O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O Project O financial O support O was O provided O by O the O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG 973 I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2015CB150300 B-AWARD the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG Central I-ORG Research I-ORG Institutes I-ORG of I-ORG Public I-ORG Interests I-ORG Grant O No. O 1610312017022 B-AWARD and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG Grant O No. O Y2016JC05 B-AWARD This O research O was O supported O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFA0900500 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31670042 O 31701079 B-AWARD 31471186 B-AWARD and O the B-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDA21060900 O This O study O was O supported O by O the O Foundation B-ORG of I-ORG He’nan I-ORG Educational I-ORG Committee I-ORG of I-ORG China I-ORG 14B230017 O the O Industry B-ORG University I-ORG Research I-ORG Cooperation I-ORG Project I-ORG of I-ORG He’nan I-ORG Science I-ORG and I-ORG Technology I-ORG Committee I-ORG of I-ORG China I-ORG 182107000041 O and O the O Science B-ORG and I-ORG Technology I-ORG Opening I-ORG Cooperation I-ORG Project I-ORG of I-ORG He’nan I-ORG Science I-ORG and I-ORG Technology I-ORG Committee I-ORG of I-ORG China I-ORG 182106000039 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O L.L O is O supported O by O grants O from O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2019A1515011416 O 2022A1515010689 B-AWARD Key B-ORG Field I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Guangdong I-ORG province I-ORG 2018B030337001 O Guangzhou B-ORG Key I-ORG Research I-ORG Program I-ORG on I-ORG Brain I-ORG Science I-ORG 202007030008 O and O Guangdong O Key O Laboratory O of O nonhuman O primate O models O of O brain O diseases O X.L O is O supported O by O the O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2014CB943001 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31371309 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O No. O 82071147 B-AWARD O 82171000 B-AWARD CSA B-ORG Clinical I-ORG Research I-ORG Fund I-ORG CSA-02020-02 O and O Research O and O Develop O Program O West B-ORG China I-ORG Hospital I-ORG of I-ORG Stomatology I-ORG Sichuan I-ORG University I-ORG No. O LCYJ2020-TD-2 O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31772508 O 31201733 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 2016JM3026 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0501502 O and O the O Chinese O Universities O Scientific O Fund O 2452015012 O This O research O was O funded O by O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2019M651724 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 51675243 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grant O No. O BK20151343 B-AWARD Neil O Brocklehurst’s O research O is O funded O by O Deutsche B-ORG Forschungsgemeinschaft I-ORG grant O number O BR B-AWARD 5724/1-1 O Gemma O Louise O Benevento’s O research O is O funded O by O a O NERC B-ORG studentship I-ORG from I-ORG the I-ORG Oxford I-ORG DTP I-ORG in I-ORG Environmental I-ORG Research I-ORG NE/L0021612/1 O alongside O additional O support O provided O by O the O European B-ORG Research I-ORG Council I-ORG grant O agreement O 637483 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG grant O no: O 2018YFD0901205 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O nos O 31721005 B-AWARD and O 31872550 B-AWARD Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG grant O no: O XDA08010106 B-AWARD and O Projects O from O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Freshwater I-ORG Ecology I-ORG and I-ORG Biotechnology I-ORG grant O nos O 2016FBZ03 B-AWARD 2015FB11 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Number O 31702285 B-AWARD the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Grant O Number O 2017YFD0501500 B-AWARD and O the B-ORG Scientific I-ORG Innovation I-ORG Project I-ORG of I-ORG Shanxi I-ORG Agricultural I-ORG University I-ORG Grant O Number O 2017001 B-AWARD This O work O was O supported O by O funding O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81400986 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2014A030313541 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Zhanjiang I-ORG No. O 2014A01031 B-AWARD and O the O Project B-ORG of I-ORG Dongguan I-ORG No. O 2013508152012 B-AWARD The O funding O agencies O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81872996 B-AWARD National O Science O O Technology O Major O Project O of O China O Grant O No. O 2018ZX09201011 O State B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG Grant O No. O 2017YFC1702104 B-AWARD and O Tianjin B-ORG Municipal I-ORG Education I-ORG Commission I-ORG Research I-ORG Project I-ORG Grant O No. O 2017ZD07 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. B-AWARD 31772772,http://www.nsfc.gov.cn O the O China B-ORG Agricultural I-ORG Research I-ORG System I-ORG CARS-42-17 O and O Sichuan B-ORG Veterinary I-ORG Medicine I-ORG and I-ORG Drug I-ORG Innovation I-ORG Group I-ORG of I-ORG China I-ORG Agricultural I-ORG Research I-ORG System I-ORG CARS-SVDIP O The O funders O MF O Liu O and O AC O Cheng O had O a O role O in O study O design O decision O to O publish O and O perparation O of O the O manuscript O This O work O is O supported O by O the O Shanghai B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG 2017SHZDZX01 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81871448 O 81671328 B-AWARD National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017ZX10203205-006-002 O Innovation B-ORG Research I-ORG Plan I-ORG supported I-ORG by I-ORG Shanghai I-ORG Municipal I-ORG Education I-ORG Commission I-ORG ZXWF082101 O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0909200 O and O Program B-ORG for I-ORG Professor I-ORG of I-ORG Special I-ORG Appointment I-ORG Eastern I-ORG Scholar I-ORG at I-ORG Shanghai I-ORG Institutions I-ORG of I-ORG Higher I-ORG Learning I-ORG 1610000043 O The O supports O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG of I-ORG China I-ORG 2017YFC0603004 O the O Key O Laboratory O “Deep O Earth O Materials O Science O and O Technology” O in O Henan O province O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51678220 O and O the O Program B-ORG for I-ORG Innovative I-ORG Research I-ORG Team I-ORG in O Science O and O Technology O 19IRTSTHN027 O in O Henan O Polytechnic O University O are O appreciated O The O authors O appreciate O the O support O from O the O Engineering O Division O in O New O York O University O Abu O Dhabi O UAE O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O T2293731 B-AWARD 62121003 B-AWARD 61960206012 B-AWARD 62171434 B-AWARD 81971348 B-AWARD 61973292 B-AWARD 61975206 B-AWARD 61971400 B-AWARD the O Scientific B-ORG Instrument I-ORG Developing I-ORG Project I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG No. O GJJSTD20210004 B-AWARD the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG No. O 2022YFC2402501 B-AWARD and O the O Major B-ORG program I-ORG of I-ORG scientific I-ORG and I-ORG technical I-ORG innovation I-ORG 2030 I-ORG No. O 2021ZD0201603 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 51704242 B-AWARD 51871132 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG in O China O grant O number O 2018JM5094 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities O grant O number O 310201911cx019 B-AWARD Funding O for O this O work O was O provided O by O EPSRC B-ORG EP/M013294/1 O EP/I036877/1 I-AWARD EP/M508378/1 O InnovateUK O 70714 O I-AWARD 492141 O and O funding O through O DSTL B-ORG contract O DSTLX-1000095040 B-AWARD This O work O was O supported O in O parts O by O National B-ORG Key I-ORG R&D I-ORG program I-ORG of I-ORG China I-ORG 2017YFC1001402 O to O H.W O 2018YFC1004102 B-AWARD to O J.L O 2018YFC1004401 B-AWARD to O S.K O and O 2018YFC1004404 B-AWARD to O B.C O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81830045 O to O H.W O 31971071 B-AWARD and O 81741035 B-AWARD to O J.L O and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 20720180041 O J.L O and O 20720180039 B-AWARD to O S.K O 20720190073 B-AWARD to O W.D O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O ideas O and O discussion O for O this O manuscript O stemmed O from O the O authors O participation O in O a O National O Science O Foundation-funded O NSF O DEB O O 1548194 B-AWARD workshop O on O seed O dispersal O held O at O the O National O Socio-Environmental O Synthesis O Center O SESYNC O funded O by O NSF O DBI-1052875 O in O May O 2016 O RSC O CC, O and O XY O were O supported O in O part O by O NSF O DMS O O 1514752 B-AWARD DZ O received O funding O from O the O Swiss B-ORG National I-ORG Science I-ORG Foundation I-ORG SNF O grant O PZ00P3_168136/1 B-AWARD and O from O the O German B-ORG Science I-ORG Foundation I-ORG DFG O grant O ZU B-AWARD 361/1-1 O We O are O grateful O to O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31401388 O and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0100503 O and O A B-ORG Project I-ORG of I-ORG Shandong I-ORG Province I-ORG Higher I-ORG Education I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG J16LF07 O for O financial O support O This O work O was O supported O by O the O fund O of O the O Young B-ORG Medical I-ORG Talents I-ORG Training I-ORG Program I-ORG of I-ORG the I-ORG Pudong I-ORG Health I-ORG Committee I-ORG of I-ORG Shanghai I-ORG Grant O No. O PWRq2020-67 B-AWARD This O study O was O supported O by O the O Science B-ORG and I-ORG Technology I-ORG Development I-ORG Fund I-ORG of I-ORG Shanghai I-ORG Pudong I-ORG New I-ORG Area I-ORG Grant O No: O PKJ2021–Y38 B-AWARD This O study O was O supported O by O the O Discipline B-ORG Construction I-ORG Promoting I-ORG Project I-ORG of I-ORG Shanghai I-ORG Pudong I-ORG Hospital I-ORG Grant O No: O Tszb2023-01 B-AWARD Zdzk2020-10 B-AWARD Zdxk2020-01 B-AWARD This O work O was O financially O supported O by O 863 B-ORG projects I-ORG 2015AA021005 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31622001 O and O the O 111 B-ORG Project I-ORG 111-2-06 O SM O and O FR O were O supported O by O funding O from O the O European B-ORG Research I-ORG Council I-ORG under O the O European O Union's O Seventh O Framework O Programme O FP/2007–2013)/ERC O Grant O Agreement O No. O 311870 O ZV O was O supported O by O the O Vienna B-ORG Science I-ORG and I-ORG Technology I-ORG Fund I-ORG WWTF O project O CS11-026 B-AWARD and O by O the O Austrian B-ORG Science I-ORG Fund I-ORG FWF O project O P21244-B17 B-AWARD EK O was O supported O by O the O Hungarian O Academy O of O Sciences O MTA O 01 O 031 O János O Bolyai O Research O Scholarship O The O authors O further O thank O many O private O sponsors O including O Royal O Canin O for O financial O support O and O the O Game O Park O Ernstbrunn O for O hosting O the O Wolf O Science O Center O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O Technology B-ORG Innovation I-ORG Team I-ORG Train I-ORG Project I-ORG of I-ORG Fuzhou I-ORG Health I-ORG Committee I-ORG in I-ORG China I-ORG 2016-S-wp1 O and O sponsored O by O key B-ORG Clinical I-ORG Specialty I-ORG Discipline I-ORG Construction I-ORG Program I-ORG of I-ORG Fuzhou I-ORG Fujian I-ORG P.R.C I-ORG 201610191 O and O Fuzhou B-ORG Children’s I-ORG Medical I-ORG Center I-ORG 2018080310 O This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG R I-ORG I-ORG D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0101803 O for O the O study O and O collection O of O data O the B-ORG Major I-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG of I-ORG Anhui I-ORG Province I-ORG China I-ORG 17030701013 O for O analysis O of O data O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31701910 O and O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Province I-ORG China I-ORG 1908085MC96 O for O interpretation O of O data O The O 2012 B-ORG National I-ORG Key I-ORG Clinical I-ORG Specialty I-ORG Construction I-ORG Project I-ORG 2012650 O The B-ORG Taishan I-ORG Scholar I-ORG Construction I-ORG Project I-ORG Special I-ORG Fund I-ORG Project I-ORG ts20130911 O The B-ORG Key I-ORG Laboratory I-ORG of I-ORG Medicine I-ORG and I-ORG Health I-ORG of I-ORG Shandong I-ORG Province I-ORG Lu O Health I-AWARD Science I-AWARD No. I-AWARD 49[2013 O This O research O was O funded O by O “National O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O U19A2029 B-AWARD and O 31701491” B-AWARD “the O Funding B-ORG of I-ORG Hunan I-ORG Provincial I-ORG Department I-ORG of I-ORG Education O grant O number O 22B0492” B-AWARD and O “College O Student I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Training I-ORG Project I-ORG in I-ORG Hunan I-ORG Province O grant O number O 3386 B-AWARD in O 2022” O This O work O was O supported O by O the B-ORG National I-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 81360657 O and O CAMS B-ORG Initiative I-ORG for I-ORG Innovative I-ORG Medicine I-ORG 2017-I2M-3-010 O The O National I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2018ZX09711003-005-004 O and O Beijing B-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG Z141102004414065 O This O study O was O supported O by O the B-ORG National I-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2011AA100304 O the B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG 13JJ1021 O and O Science B-ORG and I-ORG technology I-ORG project I-ORG of I-ORG hunan I-ORG province I-ORG 2014NK4135 O This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0200400 O the O Special B-ORG Program I-ORG for I-ORG New I-ORG Transgenic I-ORG Variety I-ORG Breeding I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG China I-ORG 2016ZX08012005 O the O State B-ORG Public I-ORG Industry I-ORG Agriculture I-ORG Research I-ORG Project I-ORG of I-ORG China I-ORG 201403031 O and O the O Postgraduate B-ORG Research I-ORG Practice I-ORG Innovation I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG KYCX17_0574 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O The B-ORG National I-ORG Modern I-ORG Agroindustry I-ORG Technology I-ORG Research I-ORG System I-ORG Fund I-ORG No.CARS-30-2-02 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31672099 B-AWARD and O 31801812 B-AWARD and O “Double B-ORG Tops” I-ORG Program I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG SYL2017YSTD10 O The O funders O did O not O play O a O role O in O the O experimental O design O of O the O study O results O analysis O or O writing O of O the O manuscript O but O did O provide O financial O support O for O the O manuscript O This O work O was O supported O by O the O Wellcome B-ORG Trust I-ORG grant O numbers O 101506/Z/13/Z B-AWARD and O Research B-ORG Training I-ORG Fellowship I-ORG 203616/Z/16/Z B-AWARD R.C O acknowledges O funding O from O the O Ministry B-ORG of I-ORG Health I-ORG of I-ORG the I-ORG Czech I-ORG Republic I-ORG grant O number O 15-27109A B-AWARD This O work O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61702068 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M632209 O the O Anhui B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG 1808085MF177 O and O the O Key O Project O of O Anhui O University O Science O Research O KJ2019A0642 O This O work O was O supported O in O part O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81573211 O and I-AWARD 81270043 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2014A030313772 O Shenzhen B-ORG Technology I-ORG and I-ORG Research I-ORG Fund I-ORG JCYJ20140410171018515 O and O JCYJ20140416104959068 O and O the O Medical O Key O Laboratory O of O Shenzhen O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O China B-ORG National I-ORG Novel I-ORG Transgenic I-ORG Organisms I-ORG Breeding I-ORG Project I-ORG 2016ZX08004-004-006 O the O Chinese B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG 31201229 O the O Foundation B-ORG for I-ORG University I-ORG Key I-ORG Teacher I-ORG of I-ORG the I-ORG Department I-ORG of I-ORG Education I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG 1253G008 O the O Academic B-ORG Backbone I-ORG Project I-ORG of I-ORG Northeast I-ORG Agricultural I-ORG University I-ORG 15XG03 O and O Harbin B-ORG Science I-ORG and I-ORG technology I-ORG innovation I-ORG program I-ORG 2017RAQXJ122 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O jointly O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O No. B-AWARD 31670521 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG grant O number O No. B-AWARD 2662015PY119 O the O National O Training O Program O of O Innovation O and O Entrepreneurship O for O Undergraduates O grant O number O No. O 201810504093 O and O the O Earmarked B-ORG Fund I-ORG for I-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG grant O number O No. B-AWARD CARS-45 O The O authors O were O funded O by O the B-ORG National I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG to O DL, O 81971957 B-AWARD by O the O Jiangsu B-ORG Provincial I-ORG Project I-ORG of I-ORG Invigorating I-ORG Health I-ORG Care I-ORG through I-ORG Science I-ORG Technology I-ORG and I-ORG Education I-ORG to O DL, O wk018-001 B-AWARD and O by O a B-ORG ZELS I-ORG research I-ORG grant I-ORG combined O BBSRC O MRC O ESRC O NERC O DSTL O O DFID O BB/L018985/1 B-AWARD to O JPW O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O in O part O by O grants O from O FONCYT B-ORG Program I-ORG of I-ORG the I-ORG National I-ORG Agency I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG Promotion I-ORG ANPCYT I-ORG PICT-2008-0998 B-AWARD National B-ORG Research I-ORG Council I-ORG CONICET I-ORG PIP B-AWARD 11220120100256CO I-AWARD and O the O University B-ORG of I-ORG Buenos I-ORG Aires I-ORG Buenos I-ORG Aires I-ORG Argentina I-ORG UBA O 20020110100146 O Financial O support O came O from O the O Cooperation B-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG I-ORG China I-ORG Forestry I-ORG Academy I-ORG 2014SY13 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31470586 O Key B-ORG Research I-ORG and I-ORG Development I-ORG plan I-ORG projects I-ORG in I-ORG Zhejiang I-ORG 2015C02058 O and O Institute B-ORG Development I-ORG Support I-ORG Projects I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2017F30015 O This O study O was O supported O by O funding O from O the O “Instituto O de I-ORG Salud I-ORG Carlos I-ORG III” O grant O numbers O CP21/00049 B-AWARD CP20/00007 B-AWARD PI21/00183 B-AWARD and O PI22/00345 B-AWARD Fundación B-ORG Eugenio I-ORG Rodriguez I-ORG Pascual I-ORG FERP-2022-5 I-ORG CIBERNED I-ORG grant O number O CB18/05/00040 B-AWARD “Agencia O Estatal I-ORG de I-ORG Investigación” O grant O number O RTI2018-096100-B-I00 B-AWARD and O PID2019-105600RB-I00 B-AWARD “Comunidad O de I-ORG Madrid” O grant O number O B2017/BMD-3813 B-AWARD and O Fundación B-ORG La I-ORG Caixa-Fundación I-ORG Luzón I-ORG grant O HR21-00931 B-AWARD Prof O Xin O Liu O greatly O appreciated O the O funding O by O Xuzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG KC17123 O Jiangsu B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 1601080C O 1701062B B-AWARD Jiangsu B-ORG University I-ORG Natural I-ORG Science I-ORG Foundation I-ORG 17KJB310015 O and O Research B-ORG Foundation I-ORG for I-ORG Talented I-ORG Scholars I-ORG in I-ORG Xuzhou I-ORG Medical I-ORG University I-ORG D2015001 O Prof O Liang O Wang O acknowledged O the O financial O support O of O National O Natural O Science O Foundation O of O China O 31900022 O Natural O Science O Foundation O of O Jiangsu O Province O BK20180997 O Jiangsu O Qinglan O Project O 2020 O and O the O Funding O of O Innovative O Science O and O Technology O Team O of O Young O Scientists O at O Xuzhou O Medical O University O TD202001 O This O study O was O supported O by O the O Basic O Science O Research O Program O of O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O funded O by O the O Ministry O of O Education O Science O and O Technology O NRF-2017R1A1A3A04069314 O and O the O Biomedical O Research O Center O funded O by O the O Ulsan B-ORG University I-ORG Hospital I-ORG UUHBRC-2016-001 O and O the O Korea O Health O Technology O R&D O Project O through O the O Korea O Health O Industry O Development O Institute O KHIDI O funded O by O the O Ministry B-ORG of I-ORG Health I-ORG I-ORG Welfare I-ORG Republic I-ORG of I-ORG Korea I-ORG HI17C0904 O This O work O was O supported O by O the O Ulsan B-ORG University I-ORG Hospital I-ORG Research I-ORG Grant I-ORG UUH-2019-06 O This O study O was O supported O by O grants O from O the B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG 201803010024 O the B-ORG Social I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Key I-ORG Project I-ORG of I-ORG Dongguan I-ORG 201750715046462 O Guangzhou B-ORG Key I-ORG Medical I-ORG Discipline I-ORG Construction I-ORG Project I-ORG Fund I-ORG B195002004042 O and O Open B-ORG Funds I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Oncology I-ORG in I-ORG South I-ORG China I-ORG KY013711 O The O funding O bodies O were O not O involved O in O the O design O of O this O study O in O the O collection O analysis O and O interpretation O of O the O data O or O in O writing O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81971863 O 82272230 O to O HF O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG 22ZR1444700 O to O HF O and O Shanghai B-ORG Shenkang I-ORG project I-ORG for I-ORG transformation I-ORG for I-ORG scientific I-ORG production I-ORG SHDC2022CRD049 O to O HF O This O research O is O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51409221 O 51979234 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0403302 O and O Humanities B-ORG and I-ORG Social I-ORG Science I-ORG Program I-ORG of I-ORG Northwest I-ORG A&F I-ORG University I-ORG Z109021405 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81703416 B-AWARD GDAS’ B-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG No. O 2019GDASYL-0402001 B-AWARD Medical B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG of I-ORG China I-ORG No. O A2017071 B-AWARD This O work O is O supported O by O the O National O Key O R&D O Program O of O China O no. O 2018YFC0910500 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG nos O 61425002 B-AWARD 61751203 I-AWARD 61772100 I-AWARD 61972266 I-AWARD 61802040 I-AWARD 61672121 I-AWARD 61572093 O the O Program O for O Changjiang O Scholars O and O Innovative O Research O Team O in O University O no. O IRT_15R07 O the O Program O for O Liaoning O Innovative O Research O Team O in O University O no.LT2017012 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province I-ORG nos O 20180551241 B-AWARD 2019-ZD-0567 O the O High-level O Talent O Innovation O Support O Program O of O Dalian O City O nos.2017RQ060 O 2018RQ75 O the O Dalian O Outstanding O Young O Science O and O Technology O Talent O Support O Program O no. O 2017RJ08 O Scientific B-ORG Research I-ORG Fund I-ORG of I-ORG Liaoning I-ORG Provincial I-ORG Education I-ORG Department I-ORG no. O JYT19051 B-AWARD This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 52122317 O 22175120 B-AWARD the O Developmental B-ORG Fund I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Shenzhen I-ORG Government I-ORG JCYJ20190808153415062 O RCYX20200714114525101 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2020B1515020011 O This O work O was O supported O by O the O following O grants O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61772321 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2016FP07 B-AWARD and O CERNET B-ORG Innovation I-ORG Project I-ORG NGII20170508 B-AWARD This O work O was O supported O by O grants O from O the O Key O Laboratory O of O Malignant O Tumor O Molecular O Mechanism O and O Translational O Medicine O of O Guangzhou B-ORG Bureau I-ORG of I-ORG Science I-ORG and I-ORG Information I-ORG Technology I-ORG Grant O 2013]163 B-AWARD the O Key O Laboratory O of O Malignant O Tumor O Gene O Regulation O and O Target O Therapy O of O Guangdong B-ORG Higher I-ORG Education I-ORG Institutes I-ORG Grant O KLB09001 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81270442 B-AWARD and O No. O 81370475 B-AWARD The O present O work O was O supported O by O CSIC B-ORG I-COOP2020 O COOPB20502 O the O Ministerio B-ORG de I-ORG Ciencia I-ORG Innovación I-ORG y I-ORG Universidades I-ORG code O PID2019-104650 B-AWARD GB-C21 I-AWARD MCIN O AEI O 10.13039/501100011033 O IT1566-22 B-AWARD Basque O Government O UBA B-ORG UBACYT O 2018-2020 I-AWARD N°20020170100381BA O ANPCyT B-ORG PICT O 2017-2362 O MINCyT B-ORG “Programa O Ciencia O y O Tecnología O Contra O el O Hambre” O IF-2021-4378615-APN-SSCI#MCT B-AWARD Monica O Fabiani O National B-ORG Institute I-ORG on I-ORG Aging O Award O ID: O R01AG059878 B-AWARD Gabriele O Gratton O NIH B-ORG Award O ID: O R56MH097973 B-AWARD Gabriele O Gratton O NCRR B-ORG Award O ID: O S10-RR029294 B-AWARD This O research O was O funded O by O the O following O grants O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG China I-ORG Grant O Number O 2019J05071 B-AWARD the B-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG Fujian I-ORG Province I-ORG China I-ORG Grant O Number O 2018-1-69 B-AWARD Startup B-ORG Fund I-ORG for I-ORG scientific I-ORG research I-ORG Fujian I-ORG Medical I-ORG University I-ORG Grant O Number O 2017XQ1001 B-AWARD Fujian B-ORG Medical I-ORG University I-ORG high I-ORG level I-ORG talents I-ORG scientific I-ORG research I-ORG start-up I-ORG funding I-ORG project I-ORG Grant O Number O XRCZX2017025 B-AWARD and O College B-ORG Students’ I-ORG innovation I-ORG and I-ORG entrepreneurship I-ORG training I-ORG program I-ORG Grant O Number O 201810392035 B-AWARD and O Grant O Number O C19065 B-AWARD L19008 B-AWARD and O L19012 B-AWARD This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61403077 O the O Natural B-ORG Science I-ORG Foundation I-ORG for I-ORG Youths I-ORG of I-ORG JiLin I-ORG Province I-ORG 20150520061JH O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2412019FZ047 O which O fund O us O to O build O the O environment O we O needed O for O our O experiments O including O facilities O for O data O collection O and O analysis O This O study O received O funding O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81872631 O 81472991 B-AWARD Key B-ORG Projects I-ORG of I-ORG Excellent I-ORG Young I-ORG Talents I-ORG Fund I-ORG in I-ORG universities I-ORG of I-ORG Anhui I-ORG Province I-ORG gxyqZD2018025 O Public B-ORG welfare I-ORG technology I-ORG application I-ORG linkage I-ORG fund I-ORG of I-ORG Anhui I-ORG provincial I-ORG science I-ORG and I-ORG technology I-ORG department I-ORG 1704F0804026 O Hefei B-ORG Municipal I-ORG Health I-ORG Planning I-ORG Commission I-ORG Applied I-ORG Medicine I-ORG Research I-ORG Project I-ORG No. O hwk2018zd002 O National B-ORG College I-ORG Student I-ORG Innovation I-ORG Training I-ORG Program I-ORG 201710366029 O Research O reported O in O this O publication O was O supported O in O part O by O U54 B-AWARD GM104940 I-AWARD from O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG of O the O National O Institutes O of O Health O which O funds O the O Louisiana O Clinical O and O Translational O Science O Center O and O OD11104 O from O the O Office O of O the O Director O at O the O National O Institutes O for O Health O BAB O These O studies O were O also O supported O in O part O by O the O National B-ORG Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences I-ORG of O the O National O Institutes O of O Health O under O award O number O TL1TR001418 B-AWARD RAS O This O publication O was O made O possible O by O funding O from O the O NIMHD-RCMI O grant O number O 5G12MD007595 B-AWARD from O the O National B-ORG Institute I-ORG on I-ORG Minority I-ORG Health I-ORG and I-ORG Health I-ORG Disparities I-ORG and O the O NIGMS-BUILD O grant O number O 8UL1GM118967 B-AWARD MRB O and O GW O This O publication O was O also O made O possible O by O the O Louisiana O Cancer O Research O Consortium O and O was O facilitated O in O part O by O the O Cell O Molecular O and O Bioinformatics O Core O facility O at O Xavier O University O MRB O and O GW O The O contents O are O solely O the O responsibility O of O the O authors O and O do O not O necessarily O represent O the O official O views O of O the O NIMHD O This O work O was O partially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81570732 O Shaohua O Wang O and O No.81870568 O Shaohua O Wang O the O National B-ORG Nature I-ORG Science I-ORG Youth I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81200635 B-AWARD Yang O Yuan O and O the O Jiangsu B-ORG Provincial I-ORG Medical I-ORG Youth I-ORG Talent I-ORG QNRC2016819 O Yang O Yuan O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0501203 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG C2017009 O and O the O Heilongjiang B-ORG Postdoctoral I-ORG Scientific I-ORG Research I-ORG Developmental I-ORG Fund I-ORG LBH-Q15004 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Joint B-ORG Foundation I-ORG of I-ORG the I-ORG Health I-ORG Commission I-ORG of I-ORG Hubei I-ORG Province I-ORG Grant O No. O WJ2018H173 B-AWARD the O Central B-ORG Funds I-ORG Guiding I-ORG the I-ORG Local I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG of I-ORG Hubei I-ORG Province I-ORG Grant O No. O 2019ZYYD066 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81271872 B-AWARD This O study O was O funded O by O the B-ORG National I-ORG Key I-ORG R&D I-ORG program I-ORG of I-ORG China I-ORG 2018YFB1105700 O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2019kfyXMBZ063 O and O the B-ORG Graduates’ I-ORG Innovation I-ORG Fund I-ORG of I-ORG Huazhong I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2019ygscxcy066 O This O work O was O supported O by O the O Fondo B-ORG para I-ORG la I-ORG Investigación I-ORG Científica I-ORG y I-ORG Tecnológica I-ORG PICT O 2013-2757 O Secretaria B-ORG de I-ORG Ciencia I-ORG Técnica I-ORG y I-ORG Posgrado I-ORG Universidad I-ORG Nacional I-ORG de I-ORG Cuyo I-ORG AR) O Proyectos O de I-AWARD Investigación I-AWARD 2016-2018 O Consejo B-ORG Nacional I-ORG de I-ORG Investigaciones I-ORG Científicas I-ORG y I-ORG Tecnológicas I-ORG CONICET-PIP O 2014-2016 O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG No. O 2013CB733600 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 201276081 B-AWARD National B-ORG Key I-ORG Technology I-ORG Support I-ORG Program I-ORG of I-ORG China I-ORG No. O 2011BAF02B05 B-AWARD This O work O was O partially O supported O by O Jiangsu B-ORG Province’s I-ORG Key I-ORG Discipline/Laboratory I-ORG of I-ORG Medicine I-ORG ZDXKA2016025 O Jiangsu B-ORG Province’s I-ORG Key I-ORG Provincial I-ORG Talents I-ORG Program I-ORG ZDRCA2016082 O and O the O Jiangsu B-ORG Provincial I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG SBE2018750279 O This O study O received O support O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFE0103800 O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIAID O 1R01AI114310-01 I-AWARD NIAID I-AWARD K24AI143471 I-AWARD NICHD I-AWARD UG3HD096929 O the O UNC B-ORG Center I-ORG for I-ORG AIDS I-ORG Research I-ORG NIAID O 5P30AI050410 O and O the O North B-ORG Carolina I-ORG Translational I-ORG I-ORG Clinical I-ORG Sciences I-ORG Institute I-ORG 1UL1TR001111 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O work O was O supported O by O The O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O No. O 81360668 B-AWARD This O research O work O was O supported O by O Jiangxi B-ORG traditional I-ORG medicine I-ORG with I-ORG modern I-ORG science I-ORG and I-ORG technology I-ORG industry I-ORG development I-ORG center I-ORG open I-ORG innovation I-ORG fund I-ORG project I-ORG of I-ORG China I-ORG No. O JXXT201403001 B-AWARD This O research O work O was O supported O by O the O Tianshan B-ORG talent I-ORG project I-ORG of I-ORG Xingjiang I-ORG Medical I-ORG University I-ORG No. O Y0382023 B-AWARD This O work O was O supported O by O National B-ORG Institutes I-ORG of I-ORG Health O USA O grant O R01CA160688 B-AWARD Susan B-ORG G. I-ORG Komen I-ORG Foundation O grant O CCR17481211 B-AWARD to O K.T O and O National B-ORG Cancer I-ORG Institute O USA O cancer O center O support O grant O P30-CA016056 B-AWARD to O Roswell O Park O Comprehensive O Cancer O Center O RPCCC O This O work O was O supported O by O the O Khon B-ORG Kaen I-ORG University I-ORG I62-00-21-03 O I62-00-21-02 B-AWARD the O Thailand B-ORG Research I-ORG Fund I-ORG BDG6080006 O the O Royal O Scholarship O under O Her O Royal O Highness O Princess O Maha O Chakri O Sirindhorn O Education O Project O to O the O Kingdom O of O Cambodia O the O Thailand B-ORG Center I-ORG of I-ORG Excellence I-ORG for I-ORG Life I-ORG Sciences I-ORG Public O Organization O the O Faculty O of O Pharmaceutical O Sciences O and O Research O Transfer O Affairs O Khon O Kaen O University O Thailand O This O work O was O supported O by O Ministry B-ORG of I-ORG Education I-ORG Youth I-ORG and I-ORG Sport I-ORG of I-ORG the I-ORG Czech I-ORG Republic O IGA_PrF_2016_020;http://www.msmt.cz B-AWARD the O European B-ORG Social I-ORG Fund O CZ.1.07/2.3.00/20.0009;http://ec.europa.eu/esf/home.jsp B-AWARD National B-ORG Program I-ORG of I-ORG Sustainability O LO1304;http://www.msmt.cz B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O partially O supported O by O funding O from O the O Komen O for O the O Cure O Graduate O Training O in O Disparities B-ORG Research I-ORG Program I-ORG GTDR14299438 O Fellowship O to O ANH O and O MLC O the O Cancer O Biology O Graduate O Program O at O the O Wayne O State O University O School O of O Medicine O and O Barbara O Ann O Karmanos O Cancer O Institute O to O ANH O and O National B-ORG Institutes I-ORG of I-ORG Health I-ORG under O Ruth O L. O Kirschstein O National O Research O Service O Award O T32 B-AWARD HG008962 I-AWARD from O the O National O Human O Genome O Research O Institute O to O ANH O for O design O and O conduct O of O the O study O and O collection O management O analysis O and O interpretation O of O the O data O This O work O was O also O supported O in O part O by: O the O Epidemiology B-ORG Research I-ORG Core I-ORG and I-ORG NIH I-ORG Center I-ORG Grant O P30 B-AWARD CA022453 I-AWARD to O the O Karmanos O Cancer O Institute O at O Wayne B-ORG State I-ORG University I-ORG and I-ORG Health I-ORG and I-ORG Human I-ORG Services I-ORG contract O HHSN2612013011I B-AWARD for O conduct O of O the O study O and O by O the O University O of O Utah O Study O Design O and O Biostatistics O Center O with O funding O in O part O from O the O Huntsman O Cancer O Institute O the O National O Cancer O Institute O of O the O National O Institutes O of O Health O under O Award O Number O P30 O CA042014 O the O National O Center O for O Research O Resources O and O the O National O Center O for O Advancing O Translational O Sciences O National O Institutes O of O Health O through O Grant O 8UL1TR000105 O formerly O UL1RR025764 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31701738 B-AWARD the O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG No. O 2013CB127701 B-AWARD and O the O Special B-ORG Fund I-ORG for I-ORG Agro-scientific I-ORG Research I-ORG in I-ORG Public I-ORG Interest I-ORG No. O 201303016 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O and O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81200628 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG grant O number O 12ZR1417800 B-AWARD and O the O Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Fund I-ORG grant O number O 08411953000 B-AWARD This O study O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0212003 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 91643207 O 81273083 B-AWARD and O the O Hubei B-ORG Province I-ORG Health I-ORG I-ORG Family I-ORG Planning I-ORG Scientific I-ORG Research I-ORG Project I-ORG WJ2017Z001 O This O work O was O supported O by O the O Ministry O of O Education O Youth O and O Sports O of O the O Czech O Republic O project O CEITEC2020 B-ORG LQ1601 O European O Union’s O Horizon B-ORG 2020 I-ORG research O and O innovation O programme O under O grant O agreement O No B-AWARD 692298 I-AWARD MEDGENET O the O Ministry O of O Health O of O the O Czech O Republic O research O grants O AZV-MZ-CR B-ORG 15-30015A B-AWARD and I-AWARD 15-31834A O the O Medical B-ORG Faculty I-ORG of I-ORG Masaryk I-ORG University I-ORG grant I-ORG no. O MUNI/A/0968/2017 B-AWARD the O European O Regional O Development O Fund-Project O “EATRIS-CZ” O No. O CZ.02.1.01/0.0/0.0/16_013/0001818 B-AWARD the O research O grant O TACR O TEO2000058/2014-2019 O and O by O research O infrastructure O EATRIS-CZ O ID O number O LM2015064 O funded O by O MEYS O CR. O This O article O reflects O only O the O author’s O view O and O the O Research O Executive O Agency O is O not O responsible O for O any O use O that O may O be O made O of O the O information O it O contains O The O funding O body O did O not O affect O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31802069 O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0500505 O and O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Southwest I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 19zx7115 O TE O was O supported O by O a O postdoctoral O fellowship O from O the O Japan B-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG and O the O Royal O Society O JSPS/FF1/435 O This O work O was O supported O by O grants O from O the O Medical B-ORG Research I-ORG Council I-ORG MR/T026014/1 O and O G0801271 B-AWARD and O the O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG BB/X510697/1 O and O BB/C516779/1 B-AWARD This O study O was O funded O by O Social B-ORG Science I-ORG Foundation I-ORG Research I-ORG Projects I-ORG of I-ORG Beijing I-ORG 16JDGLA028 O to O XN, O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 71874043 O 71473063 B-AWARD to O LF O and O also O was O funded O by O the O Innovative B-ORG Research I-ORG Projects I-ORG of I-ORG Graduate I-ORG Students I-ORG at I-ORG Harbin I-ORG Medical I-ORG University I-ORG YJSCX2017-15HYD O to O LS. O This O study O was O supported O by O grants O from O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC1312600 O 2018YFC1312604 B-AWARD to O Y.G O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81772674 O to O Y.G O and O the O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG 18140900200 O to O Y.G O This O research O was O financially O supported O by O grants O from O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG for O Distinguished O Young O Scholars O Grant O Nos O 2017JJ1022 B-AWARD the B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Hunan I-ORG Province I-ORG Grant O Nos O 2018NK2072 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 31430088 B-AWARD and O 31210103918 B-AWARD the O Major O Program O of O the O Educational O Commission O of O Hunan O Province O Grant O No. O 17A133 O the O State O Key O Laboratory O of O Developmental O Biology O of O Freshwater O Fish O the O Cooperative O Innovation O Center O of O Engineering O and O New O Products O for O Developmental O Biology O of O Hunan O Province O 20134486 O the O Earmarked O Fund O for O China O Agriculture O Research O System O CARS-45 O and O the O Construction O Project O of O Key O Disciplines O of O Hunan O Province O and O China O C.F O is O supported O by O a O Wellcome B-ORG Trust I-ORG grant O WT108720 O J.G.S O is O supported O by O an O Australian B-ORG National I-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG Practitioner I-ORG Fellowship I-ORG grant O APP1105807 O A.R O is O supported O by O the O Norwegian B-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Onsager I-ORG Fellowship I-ORG Program I-ORG in I-ORG Psychopathology I-ORG and I-ORG Development I-ORG 70440154 O This O work O was O supported O by O grants O of O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. O LQ17C160002 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31700616 B-AWARD Central O Public-Interest O Scientific O Institution O Basal O Research O Fund O No. O 1610212018012 O the O Earmarked B-ORG Fund I-ORG for I-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG No. O CARS-23 B-AWARD and O the O Science O and O Technology O Innovation O Project O of O Chinese O Academy O of O Agricultural O Sciences O No. O CAAS-ASTIP-TRICAAS O The O project O described O used O the O Tissue O Culture O and O Biobanking O Flow O Cytometry O and O Cell O Sorting O Microscopy O and O Imaging O Animal O Model O Histopathology O and O Tissue O and O Genomics O and O Epigenomics O shared O resources O which O are O partially O supported O by O award O number O P30CA051008 B-AWARD PI: O L. O Weiner O from O the O NCI B-ORG Research O reported O in O this O publication O was O supported O by O NIH B-ORG grants O R01CA205632 B-AWARD and O R21CA226542 B-AWARD and O NIH B-ORG training I-ORG grants O TL1TR001431 B-AWARD T32CA009686 B-AWARD and O F30CA243357 B-AWARD The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O National O Institutes O of O Health O This O research O was O supported O by O theESRC O Centre I-ORG for I-ORG Population I-ORG Change(grant O number O ES/K007394/1 B-AWARD with O initial O conceptualisation O of O the O research O supported O by O the O AGEGlobe O Network O funded O under O theESRC O Ageing I-ORG and I-ORG Well-being I-ORG in I-ORG a I-ORG Globalising I-ORG World(grant O number O ES/K005979/1 B-AWARD and O theESRC O Pathfindersgrant O RES-238-25-0044 O at O the O University O of O Southampton O Medical B-ORG Research I-ORG Council I-ORG MR/M010694/1 O to O R.J.C O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG BB/M003671/1 O to O R.J.C O Biological O Sciences O Research O Council O Doctoral O Training O Programme O at O the O University B-ORG of I-ORG Glasgow I-ORG BB/J013854/1 O Funding O for O open O access O charge O UK O Research O and O Innovation O This O study O is O supported O by O grants O from O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG grant O no. O 81502188 B-AWARD Central B-ORG Guidance I-ORG for I-ORG Special I-ORG Funds I-ORG grant O no. O 2016007011 B-AWARD the O Clinical B-ORG Capability I-ORG Construction I-ORG Project I-ORG for I-ORG Liaoning I-ORG Provincial I-ORG Hospitals I-ORG grant O no. O LNCCC-C05-2015 B-AWARD and O the O project O of O Key B-ORG Labouratory I-ORG of I-ORG Liaoning I-ORG Breast I-ORG Cancer I-ORG Research I-ORG grant O no. O 2016-26-1 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O Technology B-ORG Commission I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2013B020304002 O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD100504 O the O Foundation B-ORG of I-ORG Young I-ORG Creative I-ORG Talents I-ORG in I-ORG Higher I-ORG Education I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017KQNCX020 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31572089 O and I-AWARD 31801831 O the O Modern B-ORG Agricultural I-ORG Industry I-ORG Technology I-ORG System I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2016LM1128 O and O the O Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG for I-ORG Chinese I-ORG Academy I-ORG of I-ORG Tropical I-ORG Agricultural I-ORG Sciences I-ORG No. O 1630032018015 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Croatian B-ORG Science I-ORG Foundation I-ORG grants O IP-2014-09-9730 B-AWARD and O IP-2019-04-3584 B-AWARD to O G.Š O by O the O Scientific O Centre O of O Excellence O for O Basic O Clinical O and O Translational O Neuroscience O CoRE-NEURO O “Experimental O and O clinical O research O of O hypoxic-ischemic O damage O in O perinatal O and O adult O brain” O GA O KK01.1.1.01.0007 B-AWARD funded O by O the O European B-ORG Union I-ORG through O the O European O Regional O Development O Fund O and O in O part O by O NIH B-ORG grant O P30 B-AWARD AG066514 I-AWARD to O P.R.H O This O work O was O supported O by O theSwedish O Cancer I-ORG Society(12 O 0686 O theSwedish O Radiation I-ORG Safety I-ORG Authority(SSM2015-2371 O theKing O Gustav I-ORG V I-ORG Jubilee I-ORG Clinic I-ORG Cancer I-ORG Research I-ORG Foundation(2014:33 O and O theSwedish O Federal I-ORG Government I-ORG under I-ORG ALF I-ORG agreement(ALFGBG-440231 O This O study O was O funded O by O the O Air B-ORG Force I-ORG Office I-ORG of I-ORG Scientific I-ORG Research I-ORG grant O no. O FA8655-12-2112 B-AWARD and O the O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG grant O no. O BB/J014400/1 B-AWARD J.C.P O was O funded O by O the O Australian B-ORG Research I-ORG Council I-ORG Discovery O Project O Grant O DP160102658 B-AWARD This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC1306900 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81874327 O Sanming B-ORG Project I-ORG of I-ORG Medicine I-ORG in I-ORG Shenzhen I-ORG SZSM201811057 O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Hunan I-ORG Province I-ORG 2019SK2251 O and O Innovation B-ORG and I-ORG Research I-ORG Project I-ORG of I-ORG Development I-ORG and I-ORG Reform I-ORG Committee I-ORG of I-ORG Hunan I-ORG Province I-ORG 2019-875 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of O China O 81500213 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Sichuan I-ORG Province O China O 2013FZ0089 O and O Basic B-ORG and I-ORG Frontier I-ORG Research I-ORG Projects I-ORG of I-ORG Chongqing O China O tc2014jcyjA10017 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O authors O were O supported O by O grants O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81670820 O 81670818 O the B-ORG Young I-ORG Scientist I-ORG Excellence I-ORG Program I-ORG Shanghai I-ORG 2017YQ055 O the O Development O Fund O for O Shanghai O Talents O 2017 O and O the O New I-ORG Technology I-ORG Joint I-ORG Research I-ORG Project I-ORG in I-ORG Shanghai I-ORG Hospitals I-ORG SHDC12014114 O The O sponsor O or O funding O organization O had O no O role O in O the O design O or O conduct O of O this O research O This O study O was O supported O in O part O by O the O Henry B-ORG Ford I-ORG Health I-ORG System I-ORG Research I-ORG Grants I-ORG for I-ORG the I-ORG Immunology I-ORG Program I-ORG T71016 O to O QM O and O T71016 O to O LZ O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81670801 O to O JZ O the O Education B-ORG Agency I-ORG of I-ORG Sichuan I-ORG Province I-ORG Grants I-ORG 15ZB0202 O to O QY O the O Sichuan B-ORG Medical I-ORG Association I-ORG Grants I-ORG S16027 O to O QY O and O the O National B-ORG Key I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0903500 O to O YQ O The O funders O had O no O role O in O the O study O design O data O collection O analysis O or O interpretation O of O the O data O or O in O writing O the O manuscript O or O the O decision O to O submit O the O manuscript O D.L O is O supported O by O a O scholarship O from O the O University O of O Adelaide O Y.S O is O supported O by O the O Australian B-ORG Research I-ORG Council I-ORG ARC O DP190103705 O R.T O is O an O ARC B-ORG DECRA I-ORG fellow I-ORG DE190101069 O B.L O is O an O ARC B-ORG Future I-ORG Fellow I-ORG FT170100448 O This O work O was O supported O by O grants O from O the O New B-ORG York I-ORG State I-ORG Energy I-ORG Research I-ORG and I-ORG Development I-ORG Authority I-ORG contract O no. O 32971 B-AWARD and O National B-ORG Institute I-ORG of I-ORG Environmental I-ORG Health I-ORG Sciences I-ORG grant O no. O P30 B-AWARD ES001247 O Daniel O Croft O and O Kristin O Evans O were O supported O by O a O National B-ORG Institutes I-ORG of I-ORG Health I-ORG training O grant O T32-HL066988-1 O The O research O was O supported O by O grants O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31201797 O the B-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG ASTIP-IAS04 O the B-ORG earmarked I-ORG fund I-ORG for I-ORG modern I-ORG agro-industry I-ORG technology I-ORG research I-ORG system I-ORG CARS-42 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Faculty B-ORG of I-ORG Tropical I-ORG Medicine I-ORG Mahidol I-ORG University I-ORG grant O number O 04/2556 B-AWARD and O the O National B-ORG Research I-ORG Council I-ORG of I-ORG Thailand I-ORG grant O number O 32/2558 B-AWARD The B-ORG Deutscher I-ORG Akademischer I-ORG Austauschdienst I-ORG DAAD O German O Academic O Exchange O Service O fund O for O the O student O scholar O grant O number O 577177105 B-AWARD There O was O no O additional O external O funding O received O for O this O study O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31772492 B-AWARD the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG No. O XDA19050303 B-AWARD the O Youth B-ORG Innovation I-ORG Promotion I-ORG Association I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG No. O 2020087 B-AWARD and O the B-ORG Second I-ORG Tibetan I-ORG Plateau I-ORG Scientific I-ORG Expedition I-ORG and I-ORG Research I-ORG STEP I-ORG program I-ORG No. O 2019QZKK0501 B-AWARD The O authors O would O like O to O thank O for O the O support O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81570135 B-AWARD National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Equipment I-ORG Projects I-ORG of I-ORG China I-ORG Grant O No. O 2013YQ03065109 B-AWARD and O Shanghai B-ORG Public I-ORG Health I-ORG Project I-ORG Grant O No. O 15GWZK0501 B-AWARD Project O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81903006 B-AWARD Changning B-ORG Key I-ORG Discipline I-ORG No. O 20191002 B-AWARD and O Changning B-ORG District I-ORG Innovation I-ORG Talent I-ORG Base I-ORG No. O RCJD2021S01 B-AWARD We O acknowledge O partial O funding O through O the O European B-ORG Commission’s I-ORG Directorate I-ORG General I-ORG for I-ORG Research I-ORG within I-ORG the I-ORG 7th I-ORG Framework I-ORG Program I-ORG FP7/2007–2013 O under O Grant O 211982 B-AWARD RENEWALL O the O IWT-SBO B-ORG project I-ORG BIOLEUM I-ORG Grant O No. O 130039 B-AWARD and O by O SBO-FISH B-ORG through O the O ARBOREF B-AWARD project O L.d.V O B.D.M O and O L.S O were O funded O by O the O Institute O for O the O promotion O of O Innovation O through O Science O and O Technology O in O Flanders O IWT-Vlaanderen O for O a O predoctoral O fellowship O R.V O was O funded O by O the O Research O Foundation-Flanders O FWO O for O a O postdoctoral O fellowship O This O study O was O supported O by O Science B-ORG and I-ORG Technology I-ORG Fundamental I-ORG Resources I-ORG Investigation I-ORG Program I-ORG Grant O No. O 2022FY100705 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 42201162 B-AWARD and O 42272339 B-AWARD the O Foundation B-ORG of I-ORG the I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Frozen I-ORG Soil I-ORG Engineering I-ORG Grants O No. O SKLFSE-ZY-20 B-AWARD SKLFSE201913 B-AWARD SKLFSE-ZQ-58 B-AWARD and O SKLFSE-ZT-202203 B-AWARD the O program O of O Gansu B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Foundation I-ORG for I-ORG Youths I-ORG Grant O No. O 22JR5RA089 B-AWARD the O Second B-ORG Tibetan I-ORG Plateau I-ORG Scientific I-ORG Expedition I-ORG and I-ORG Research I-ORG STEP I-ORG program I-ORG Grant O No. O 2019QZKK0905 B-AWARD This O research O was O funded O by O Generalitat B-ORG Valenciana I-ORG grant O numbers O CIAPOS/2021/106 B-AWARD and O CIAICO/2021/122 B-AWARD Jaume B-ORG I I-ORG University I-ORG grant O numbers O POSDOC/2021/18 B-AWARD and O UJI-B2019-30 B-AWARD FAPESP B-ORG grant O numbers O 2013/07296-2 B-AWARD and O 2022/08048-1 B-AWARD and O CNPq B-ORG grant O number O 164227/2020-2 B-AWARD This O research O was O partly O funded O by O the O International B-ORG Foundation I-ORG for I-ORG Science I-ORG IFS O grant O number O C/5315-1 B-AWARD the O project O of O the O University B-ORG of I-ORG Catania I-ORG Italy I-ORG “Investigation O of O phytopathological O problems O of O the O main O Sicilian O productive O contexts O and O eco-sustainable O defense O strategies O MED-IT-ECO)” O “PiaCeRi—PIAno O di O inCEntivi O per O la O Ricerca O di O Ateneo O 2020–22 O linea O 2” O 5A722192155 O the O project O “Smart O and O innovative O packaging O postharvest O rot O management O and O shipping O of O organic O citrus O fruit O BiOrangePack)” O under O Partnership O for O Research B-ORG and I-ORG Innovation I-ORG in I-ORG the I-ORG Mediterranea I-ORG Area I-ORG PRIMA)-H2020 O E69C20000130001 O and O by O the O project O “PROMETEO—Un O village O transfrontalier O pour O protéger O la O culture O des O arboricoles O méditerranéennes O en O partageant O les O connaissances” O Rif O n° O C-5_2.1-36 B-AWARD Strategic O project O ENI B-ORG Italy-Tunisia I-ORG 2014–2020 O This O work O was O supported O by O China B-ORG Scholarship I-ORG Council I-ORG 201806700006 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO. O 61803143 B-AWARD and O 61703135 B-AWARD and O National B-ORG Key I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG NO. O 2015BAI06B03 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31370014 B-AWARD the O Opening B-ORG Project I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Tea I-ORG Plant I-ORG Biology I-ORG and I-ORG Utilization I-ORG No. O SKLTOF20150113 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG For I-ORG the I-ORG Central I-ORG Universities I-ORG No. O KYZ201509 B-AWARD This O work O was O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG IOS-1021633 O to O C.M.D O and O IOS-1601685 B-AWARD to O C.M.D O and O K.N.S O and O the O Duke B-ORG University I-ORG Graduate O School O Judy O C. I-AWARD Woodruff I-AWARD Fellowship O Fred B-AWARD and I-AWARD Barbara I-AWARD Sutherland I-AWARD Fellowship I-AWARD and O Katherine B-AWARD Goodman I-AWARD Stern I-AWARD Fellowship I-AWARD to O K.N.S O Vehicle O costs O in O the O field O were O supported O by O Duke O University O research O funds O to O C.M.D O We O relied O on O records O of O individual O life O histories O and O access O to O a O field O site O maintained O by O the O Kalahari O Meerkat O Project O KMP O During O the O span O of O this O study O the O KMP O was O supported O by O the O European B-ORG Research I-ORG Council I-ORG Research O grant O no. O 294494 B-AWARD to O T.H.C.-B O the O University O of O Cambridge O the O University O of O Zurich O the O Mammal O Research O Institute O at O the O University O of O Pretoria O and O Duke O University O The O study O was O supported O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81703791 B-AWARD and O No. O 81873178 B-AWARD Shanghai B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG No. O 201840240 B-AWARD Training B-ORG Program I-ORG for I-ORG Excellent I-ORG Young I-ORG Doctors I-ORG of I-ORG Health I-ORG System I-ORG of I-ORG Pudong I-ORG New I-ORG Area I-ORG of I-ORG Shanghai I-ORG No. O PWRq2017-06 B-AWARD Science B-ORG and I-ORG Technology I-ORG Development I-ORG Fund I-ORG of I-ORG Shanghai I-ORG Pudong I-ORG New I-ORG Area I-ORG No. O PKJ2017-Y13 B-AWARD and O Talents B-ORG Training I-ORG Program I-ORG of I-ORG Seventh I-ORG People’s I-ORG Hospital I-ORG of I-ORG Shanghai I-ORG University I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG No. O QMX2017-01 B-AWARD and O No. O XX2017-04 B-AWARD The O work O was O supported O by O Ministério B-ORG da I-ORG Saúde I-ORG PROADI-SUS O 25000.028646/2018-10 B-AWARD the O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo I-ORG – O FAPESP O Grant O nº O 13/21728-2 B-AWARD to O LVB O and O CDSA O and O the O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG Grant O nº O 301550/2017-4 B-AWARD to O LVB O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41605067 O Basic B-ORG Research I-ORG Operating I-ORG Expenses I-ORG of I-ORG the I-ORG Central I-ORG level I-ORG Non-profit I-ORG Research I-ORG Institutes I-ORG IDM201506 O National O Natural O Science O Foundation O of O China O 41375101 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2016M592915XB O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O by O a O grant-in-aid O from O the O Heart B-ORG and I-ORG Stroke I-ORG Foundation I-ORG of I-ORG Canada I-ORG G-17-0018639 O J.P.L O is O supported O by O a O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG CIHR O New O Investigator O Salary O Award O MSH-141980 O 2015-2020 O a O Michael B-ORG Smith I-ORG Foundation I-ORG for I-ORG Health I-ORG Research I-ORG MSFHR O Scholar O Award O 16890 O 2017-2022 O H.N O was O supported O by O a O Natural O Science O and O Engineering O Research O Council O NSERC O CGSM O scholarship O This O work O was O jointly O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 41675153 B-AWARD 31270518 B-AWARD and O 31170573 B-AWARD the O Key O development O program O of O the O Chinese B-ORG Academy I-ORG Science I-ORG KFZD-SW-302-01 O and O the O Key B-ORG Project I-ORG of I-ORG NSFC I-ORG 90411019 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2021YFB3702800 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O 51973175 O the O Scientific B-ORG and I-ORG Technological I-ORG Research I-ORG Program I-ORG of I-ORG Chongqing I-ORG Municipal I-ORG Education I-ORG Commission I-ORG KJQN202200208 O the O Project B-ORG for I-ORG Chongqing I-ORG University I-ORG Innovation I-ORG Research I-ORG Group I-ORG of I-ORG Chongqing I-ORG Education I-ORG Committee I-ORG CXQT19008 O the O Chongqing B-ORG Talent I-ORG Plan I-ORG for I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Demonstration I-ORG Team I-ORG CQYC201903243 O the O Key B-ORG R&D I-ORG Project I-ORG of I-ORG Sichuan I-ORG Province I-ORG 22ZDYF3173 O the O Technological B-ORG Innovation I-ORG and I-ORG Application I-ORG Development I-ORG “Overall I-ORG Rationing I-ORG System” I-ORG Project I-ORG of I-ORG Chongqing I-ORG Talent I-ORG Plan I-ORG cstc2021ycjh-bgzxm0307 O and O the O Project B-ORG of I-ORG Key I-ORG Laboratory I-ORG of I-ORG Processing I-ORG and I-ORG Quality I-ORG Evaluation I-ORG Technology I-ORG of I-ORG Green I-ORG Plastics I-ORG of I-ORG China I-ORG National I-ORG Light I-ORG Industry I-ORG Council I-ORG PQETGP2021009 O This O research O was O supported O by O Grant O YIG-1-034-11 B-AWARD awarded O to O ACR O and O PSL O from O the O American B-ORG Foundation I-ORG for I-ORG Suicide I-ORG Prevention O The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O American O Foundation O for O Suicide O Prevention O This O research O was O also O supported O in O part O by O a O New O Investigator O Salary O Award O MSH–130177 O from O the O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG and O an O Early O Researcher O Award O ER14-10-185 O from O the O Ministry B-ORG of I-ORG Research I-ORG and I-ORG Innovation O Province O of O Ontario O to O ACR O This O research O was O funded O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program O grant O number O 2020YFC1807704 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 41977294 B-AWARD 41907305 B-AWARD and O 41907306 B-AWARD and O Special B-ORG Fund I-ORG Project I-ORG for I-ORG Environmental I-ORG Protection I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2022-18 O This O work O was O supported O by O the B-ORG agricultural I-ORG well-breed I-ORG project I-ORG in I-ORG Shandong I-ORG Province I-ORG 2016lzgc023 O the B-ORG Major I-ORG Key I-ORG Technology I-ORG Project I-ORG for I-ORG Independent I-ORG Innovation I-ORG in I-ORG Shandong I-ORG Province I-ORG 2014GJJS0201 O the B-ORG Innovation I-ORG Team I-ORG of I-ORG Wheat I-ORG for I-ORG Modern I-ORG Agricultural I-ORG Technology I-ORG System I-ORG in I-ORG Shandong I-ORG Province I-ORG SDAIT-04-021-09 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31601624 O and O the B-ORG Taishan I-ORG Scholar I-ORG Construction I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG tshw20130963 O None O of O these O funding O sources O were O involved O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O THRIVE O was O funded O by O the O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG NIHR I-ORG Public O Health O Research O Programme O PHR O 11/3002/01 O THRIVE O was O also O supported O by O the O Medical B-ORG Research I-ORG Council I-ORG MC_UU_12017/11 O and O Chief B-ORG Scientist I-ORG Office I-ORG SPHSU11 O This O work O was O supported O by O the O Student B-ORG Grant I-ORG Agency I-ORG of I-ORG the I-ORG University I-ORG of I-ORG West I-ORG Bohemia I-ORG in I-ORG Pilsen O grant O No. O SGS-2021-003 B-AWARD “Materials O technologies O and O diagnostics O in O electrical O engineering” O and O by O the O Slovak B-ORG Research I-ORG and I-ORG Development I-ORG Agency I-ORG under O the O contract O No. O APVV-21-0078 B-AWARD and O No. O APVV-21-0449 B-AWARD and O Grant B-ORG System I-ORG of I-ORG the I-ORG University I-ORG of I-ORG Zilina I-ORG No. O 1/2022 B-AWARD 17292 I-AWARD The B-ORG Foundation I-ORG for I-ORG Young I-ORG Scientists I-ORG of I-ORG affiliated I-ORG Hospital I-ORG of I-ORG Jiangsu I-ORG University I-ORG Grant O numbers O JDFYRC2016002 B-AWARD Jiangsu B-ORG Provincial I-ORG Medical I-ORG Youth I-ORG Talent I-ORG Grant O numbers O QNRCQ2016839 B-AWARD and O Zhenjiang B-ORG Science I-ORG and I-ORG Technology I-ORG Pillar I-ORG Program I-ORG Grant O numbers O SH2018082 B-AWARD The O study O was O fund O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 71774119 O 81872719 B-AWARD Health B-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG Shandong I-ORG Province I-ORG 2016WS0676 O the B-ORG Ph.D I-ORG Research I-ORG Fund I-ORG Project I-ORG of I-ORG Weifang I-ORG Medical I-ORG University I-ORG 2017BSQD53 O and O Social B-ORG Science I-ORG Planning I-ORG and I-ORG Research I-ORG Project I-ORG of I-ORG Shandong I-ORG Province I-ORG 19CJYJ24 O 71774119 O 81872719 O contributed O to O the O research O design O and O data O analysis O of O this O study O 2016WS0676 O 2017BSQD53 O and O 19CJYJ24 O provided O support O for O the O data O collection O interpretation O and O manuscript O writing O This O research O was O funded O by O the O National O Key O R&D O Program O of O China O Grant O No. O 2016YFA0501700 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 21703206 B-AWARD 21673074 I-AWARD and I-AWARD 21761132022 O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O No. O LY17B030008 B-AWARD Shanghai B-ORG Municipal I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O No. O 18ZR1412600 B-AWARD Young O Top-Notch O Talent O Support O Program O of O Shanghai O and O NYU-ECNU O Center O for O Computational O Chemistry O at O NYU O Shanghai O This O work O was O supported O by O the O Nature B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31971281 O 82270958 B-AWARD Innovative B-ORG Talents I-ORG Program I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2022JDRC0043 O Research B-ORG and I-ORG Develop I-ORG Program I-ORG West I-ORG China I-ORG Hospital I-ORG of I-ORG Stomatology I-ORG Sichuan I-ORG University I-ORG RD-03-202106 O This O work O was O supported O by O the O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG BB/S007768/1 O European B-ORG Research I-ORG Council I-ORG 322682 O Wellcome B-ORG Trust I-ORG 096535/Z/11/Z O This O study O was O supported O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG R01 O AI072194-08 O National B-ORG Institute I-ORG on I-ORG Minority I-ORG Health I-ORG and I-ORG Health I-ORG Disparities I-ORG 5G12MD007603 O and O National B-ORG Cancer I-ORG Institute I-ORG 2U54CA132378 O This O research O was O funded O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China O grant O number O 2016YFC1100100 B-AWARD Intergovernmental B-ORG cooperation I-ORG in I-ORG science I-ORG and I-ORG technology O grant O number O 2016YFE0125300 B-AWARD National O Key O Research O and O Development O Program O of O China O O grant O number O 2016YFB0700802 B-AWARD Major O projects O of O the O National O Social O Science O Funding O grant O number O 17ZDA019 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 81671829 B-AWARD Tsinghua O University O Initiative O Scientific O Research O Program O grant O number O 2017THZWYX07 B-AWARD The O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG nos O 51603029 B-AWARD and O 51773028 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017M623001 O and O the O National B-ORG Postdoctoral I-ORG Program I-ORG for I-ORG Innovative I-ORG Talents I-ORG BX201700044 O This O work O was O supported O by O the O Hainan B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Project I-ORG NO. O 319QN163 B-AWARD The B-ORG Fund I-ORG Project I-ORG of I-ORG Key I-ORG Laboratory I-ORG of I-ORG Integrated I-ORG Pest I-ORG Management I-ORG on I-ORG Crops I-ORG in I-ORG South I-ORG China I-ORG Ministry I-ORG of I-ORG Agriculture I-ORG P. I-ORG R. I-ORG China I-ORG NO. O SCIPM2018-04 B-AWARD and O the O Research B-ORG Initiation I-ORG Project I-ORG of I-ORG Hainan I-ORG University I-ORG NO. O KYQD[ZR]1823 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O jointly O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 71861023 B-AWARD the O Program O of O Humanities O and O Social O Science O of O Education O Ministry O of O China O No. O 18YJC630118 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. O LQ19E080003 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Ningbo I-ORG Municipality I-ORG No. O 2018A610127 B-AWARD and O Foundation O of O a O Hundred O Youth O Talents O Training O Program O of O Lanzhou O Jiaotong O University O This O study O was O supported O by O Medical B-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Project O No O A2019224 B-AWARD Cultivation B-ORG Project I-ORG of I-ORG the I-ORG First I-ORG Affiliated I-ORG Hospital I-ORG of I-ORG Guangzhou I-ORG Medical I-ORG University I-ORG Project O No O ZH201818),Guangzhou B-AWARD Education I-ORG Bureau I-ORG Project O No O 1201630393 B-AWARD 1201630044 B-AWARD and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Project O No O 81871736 B-AWARD 81802076 I-AWARD 81601394 O The O study O was O supported O by O grants O from O the O National B-ORG 13th I-ORG Five-Year I-ORG Plan I-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG grant O number O 2016YFD0500907 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 31772766 B-AWARD and O the O Innovative B-ORG Research I-ORG Team I-ORG Program I-ORG of I-ORG Department I-ORG of I-ORG Education I-ORG of I-ORG Sichuan I-ORG Province I-ORG grant O number O 13TD0057 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O Taishan B-ORG Scholars I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ts201511057 O National B-ORG Natural I-ORG Science I-ORG Foundations I-ORG of I-ORG China I-ORG 81370381 O 81570410 B-AWARD and O Logistics B-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG Chinese I-ORG PLA I-ORG 15BJZ37 O The O present O study O was O supported O by O the O grants O from O the O Guangxi B-ORG Special I-ORG Fund I-ORG for I-ORG Scientific I-ORG Base I-ORG and I-ORG Talent I-ORG GKAD17195100 O the O Fund O for O Guangxi B-ORG Innovation I-ORG Teams I-ORG of I-ORG Modern I-ORG Agriculture I-ORG Technology I-ORG gjnytxgxcxtd-03-01 O the O Fund B-ORG of I-ORG Guangxi I-ORG Key I-ORG Laboratory I-ORG of I-ORG Sugarcane I-ORG Genetic I-ORG Improvement I-ORG 16-K-02-01 O and O the O Fund B-ORG of I-ORG Guangxi I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG 2015YT02 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O F.M O is O thankful O to O the B-AWARD University B-ORG of I-ORG the I-ORG Philippines I-ORG Faculty I-AWARD Reps I-AWARD and I-AWARD Staff I-AWARD Development I-AWARD Program I-AWARD FRAS I-AWARD DP) I-AWARD for O funding O the O doctoral O studies O H.D O and O K.K O are O grateful O for O the O financial O support O of O the O Leverhulme B-ORG Trust-Royal O Society O Africa O award O AA090088 O and O the B-AWARD jointly I-AWARD funded I-AWARD UK I-AWARD Medical B-ORG Research I-ORG Council–UK I-AWARD Department I-AWARD for I-AWARD International I-AWARD Development I-AWARD MRC/DFID I-AWARD Concordat I-AWARD Agreement I-AWARD African I-AWARD Research I-AWARD Leaders I-AWARD Award I-AWARD MR/S00520X/1 I-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Project O No O 21708021 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province O China O Project O No O ZR2017BC012 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Funded O Project O Project O No O 2018M632612 B-AWARD JZ O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Number O 61702069 B-AWARD 61963001 B-AWARD and O the O Applied B-ORG Basic I-ORG Research I-ORG Foundation I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Yunnan I-ORG Province I-ORG Grant O Number O 2017FB099 B-AWARD TDL O was O supported O by O NHMRC B-ORG Grant I-ORG Grant O Number O 1123042 B-AWARD LL O and O JL O were O supported O by O the O Australian B-ORG Research I-ORG Council I-ORG Discovery I-ORG Grant I-ORG Grant O Number O DP170101306 B-AWARD TX O was O supported O by O the O National O Natural O Science O Foundation O of O China O Grant O Number O 61902372 B-AWARD and O the O Presidential B-ORG Foundation I-ORG of I-ORG Hefei I-ORG Institutes I-ORG of I-ORG Physical I-ORG Science I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Grant O Number O YZJJ2018QN24 B-AWARD NR O was O supported O by O the O National O Natural O Science O Foundation O of O China O Grant O Number O 61872405 B-AWARD 61720106004 B-AWARD The O publication O costs O were O funded O by O the O Australian O Research O Council O Discovery O Grant O Grant O Number O DP170101306 O The O funding O bodies O were O not O involved O in O the O design O of O the O study O and O collection O analysis O interpretation O of O data O or O in O writing O the O manuscript O The O authors O would O like O to O acknowledge O the O financial O support O from O the O key O research O and O development O project O of O the O introduction O of O high-level O scientific O and O technological O talents O in O Lvliang B-ORG city I-ORG 2021RC-2-5 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21607111 O and O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Projects I-ORG of I-ORG Shanxi I-ORG Province I-ORG 201803D31052 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O No. O 61501092 B-AWARD National B-ORG Science I-ORG Funds I-ORG for I-ORG Creative I-ORG Research I-ORG Groups I-ORG of I-ORG China I-ORG No. O 61421002 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O ZYGX2015KYQD016 B-AWARD and O Open B-ORG Foundation I-ORG of I-ORG Key I-ORG Laboratory I-ORG of I-ORG Photoelectric I-ORG Detection I-ORG and I-ORG Sensor I-ORG Integration I-ORG Technology I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG Grant O No. O KFJJ201502 B-AWARD This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No: O 51805550 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2018M632983 B-AWARD and O the O Sino-Germany B-ORG CSC-DAAD I-ORG Postdoc I-ORG Scholarship I-ORG Program I-ORG Grant O No. O 201709920070 B-AWARD This O work O was O supported O by O Grants O from O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG province I-ORG Grant O No. O LQ20H290003 B-AWARD Zhejiang B-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG Administration I-ORG Grant O No. O 2020ZB154 B-AWARD Zhejiang B-ORG Medical I-ORG and I-ORG Health I-ORG Plan I-ORG 2020KY755 O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81672449 O 81272239 B-AWARD This O work O was O also O supported O by O Talents B-ORG planning I-ORG of I-ORG six I-ORG summit I-ORG fields I-ORG of I-ORG Jiangsu I-ORG Province I-ORG WSW-032 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20161590 O and O the B-ORG Research I-ORG Innovation I-ORG Program I-ORG for I-ORG College I-ORG Graduates I-ORG of I-ORG Jiangsu I-ORG Province I-ORG KYLX16_1106 O This O study O was O supported O by O the O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG 2019-I2M-5-001 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81730038 O and O the O Beijing B-ORG Municipal I-ORG Science I-ORG I-ORG Technology I-ORG Commission I-ORG Z191100006619073 O This O project O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81771284 B-AWARD 81971180 B-AWARD Scientific B-ORG Research I-ORG Project I-ORG of I-ORG Wenzhou I-ORG No. O ZY2019001 B-AWARD General B-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG No. O Y201942264 B-AWARD and O Research B-ORG Unit I-ORG of I-ORG Research I-ORG and I-ORG Clinical I-ORG Translation I-ORG of I-ORG Cell I-ORG Growth I-ORG Factors I-ORG and I-ORG Diseases I-ORG Chinese I-ORG Academy I-ORG of I-ORG Medical I-ORG Science I-ORG No. O 2019RU010 B-AWARD This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 31370842 B-AWARD 11575232 I-AWARD 11835014 O The O International O Partnership O Program O of O the O Chinese B-ORG Academy I-ORG of I-ORG Sciences O grant O number O 116134KYSB20160084 B-AWARD The O Innovative O Program O of O the O Development O Foundation O of O Hefei B-ORG Center I-ORG for I-ORG Physical I-ORG Science I-ORG and I-ORG Technology O grant O number O 2016FXCX005 B-AWARD The O APC O was O funded O by O the O National O Natural O Science O Foundation O of O China O This O study O received O funding O from O European B-ORG Synchrotron I-ORG Radiation I-ORG Facility I-ORG project O no. O LS-2752 B-AWARD TSM O MH, O FL);https://www.esrf.eu/Bavaria O California I-ORG Technology I-ORG Center I-ORG BaCaTeC O project O no. O 2017]-1 B-AWARD TSM O PK);http://www.bacatec.de/en/Austrian O Science I-ORG Fund I-ORG project O no. O P31045 B-AWARD FL),https://www.fwf.ac.at/en/Münchener O Universitätsgesellschaft O MUG O project O no. O 31983 O TSM O MH),https://www.unigesellschaft.de/foerderprojekte.html O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O theFoundation O of I-ORG National I-ORG Key I-ORG Program I-ORG of I-ORG Research I-ORG and I-ORG Development I-ORG of I-ORG China(Grant O No: O 2016YFC0900803),National B-AWARD Natural I-ORG Science I-ORG Funding I-ORG of I-ORG China(Grant O No. O 81903279 B-AWARD theBill O I-ORG Melinda I-ORG Gates I-ORG Foundation(Grant O No. O OOP1148464 B-AWARD and O theNatural O Science I-ORG Fund I-ORG of I-ORG Hubei I-ORG Province(Grant O No: O 2018CFB634 B-AWARD Dr. O Guo O is O supported O by O Career O Development O Fellowship O APP1107107 B-AWARD from O theAustralian O National I-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council(NHMRC O Dr. O Li O is O supported O by O Early O Career O Fellowship O APP1109193 B-AWARD from O theAustralian O NHMRC I-ORG This O research O was O funded O by O the O Key-Area B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2019B111107002 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFE0124900 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51538007/51778370/51861165204 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG 2017B030311004 O the O Shenzhen O Science O and O Technology O Project O GJHZ20180928155819738 O and O the O Regional O Joint O Project O for O Foundation O and O Applied O Basic O Research O of O Guangdong O Province O 2019A1515110746 O This O work O was O supported O by O the O Program O for O New B-ORG Century I-ORG Excellent I-ORG Talents I-ORG in I-ORG University O NCET-12-0694 B-AWARD to O Haizhen O Mo; O the O Program B-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Team I-ORG in I-ORG Universities I-ORG of I-ORG Henan I-ORG Province I-ORG 16IRTSTHN007 O to O Haizhen O Mo; O and O Key B-ORG scientific I-ORG and I-ORG technological I-ORG projects I-ORG of I-ORG Henan I-ORG Province I-ORG NO. O 152102110086 B-AWARD to O Liangbin O Hu. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG No. O LQ22F030011 B-AWARD the O Public B-ORG Welfare I-ORG Technology I-ORG Application I-ORG and I-ORG Research I-ORG Projects I-ORG of I-ORG Zhejiang I-ORG No. O LGG22F030016 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Huzhou I-ORG No. O 2021YZ05 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O capitalized O on O the O support O of O the O Young B-ORG Scholars I-ORG in I-ORG Western I-ORG China I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG 2022 O the B-ORG grants I-ORG from I-ORG the I-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 2021M691278 O and O the B-ORG Innovative I-ORG and I-ORG Entrepreneurial I-ORG Talent I-ORG Cultivation I-ORG Shuangchuang I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG 1286010241203030 O This O work O was O supported O by O Defense B-ORG Acquisition I-ORG Program I-ORG Administration I-ORG and O Agency O for O Defense O Development O ADD O under O Contract O No. O UD170035ID B-AWARD Korea B-ORG Research I-ORG Institute I-ORG of I-ORG Chemical I-ORG Technology I-ORG KRICT O core O project O SI1941-20 O and O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O funded O by O the O Korea O government O MSIP O No. O 2017R1A2A2A05001140 B-AWARD The O work O has O been O supported O by O the O Unity O through O Knowledge O Fund O UKF O Grant O No. O 20/15 B-AWARD Croatian O Science O Foundation O HRZZ O under O the O projects O 2970 B-AWARD and O 9753 B-AWARD and O the O EOARD/AFRL B-ORG Grant O No. O FA9550-15-1-0120 B-AWARD The O authors O also O acknowledge O the O support O of O project O CeNIKS O co-financed O by O the O Croatian O Government O and O the O European O Union O through O the O European O Regional O Development O Fund O O Competitiveness O and O Cohesion O Operational O Programme O Grant O No. O KK.01.1.1.02.0013 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 81971694 B-AWARD the O Scientific B-ORG Research I-ORG Foundation I-ORG of I-ORG Tianjin I-ORG Medical I-ORG University I-ORG School I-ORG and I-ORG Hospital I-ORG of I-ORG Stomatology O grant O number O 2020YKYQ02 B-AWARD and O Tianjin B-ORG Key I-ORG Medical I-ORG Discipline I-ORG Specialty I-ORG Construction I-ORG Project O grant O number O TJYXZDXK-038A B-AWARD This O research O is O supported O by O the B-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Program I-ORG of I-ORG Chongqing I-ORG Municipal I-ORG Education I-ORG Commission I-ORG Grant O No. O KJ1713330 B-AWARD Research B-ORG Foundation I-ORG of I-ORG Chongqing I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Grant O No. O ck2017zkyb025 B-AWARD and O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 61601068 B-AWARD This O study O is O supported O by O China B-ORG Scholarship I-ORG Council I-ORG CSC O No. O 201703780011 B-AWARD People’s O Republic O of O China O and O Population O and O Health O Research O Group O PHRG O School O of O Geography O and O Sustainable O Development O University O of O St O Andrews O United O Kingdom O PM2.5 O data O in O this O study O is O from O the O work O of O Yang O Liu O supported O by O the O National B-ORG Institute I-ORG of I-ORG Environmental I-ORG Health I-ORG Sciences I-ORG of O the O National O Institutes O of O Health O USA O Grant O No. O 1R01ES032140 B-AWARD This O study O is O also O supported O by O the O Centre B-ORG for I-ORG Population I-ORG Change I-ORG CPC O ES/R009139/1 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O jointly O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31601220 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG QC2016031 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2016M601464 O Support B-ORG Program I-ORG for I-ORG Natural I-ORG Science I-ORG Talent I-ORG of I-ORG Heilongjiang I-ORG Bayi I-ORG Agricultural I-ORG University I-ORG ZRCQC201806 O Heilongjiang O Bayi O Agricultural O University O Innovative O Research O Team O Foundation O TDJH201807 O This O study O was O supported O by O the O National B-ORG Medical I-ORG Research I-ORG Council I-ORG Singapore I-ORG NMRC/CIRG/1354/2013 O and O National B-ORG Institutes I-ORG of I-ORG Health I-ORG USA I-ORG RO1 O CA144034 I-AWARD and O UM1 B-AWARD CA182876 O Liang O Sun O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 8151101068 O and O 81700700 B-AWARD Xu O Lin O is O supported O by O the O Ministry O of O Science O and O Technology O of O China O 2017YFC0909700 O and O the O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG ZDBS-SSW-DQC-02 O Woon-Puay O Koh O is O supported O by O the O National O Medical O Research O Council O Singapore O NMRC/CSA/0055/2013 O A O Pan O is O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0907504 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31772772,http://www.nsfc.gov.cn B-AWARD Recipient O M.L O International B-ORG S&T I-ORG Cooperation I-ORG Program I-ORG of I-ORG Sichuan I-ORG Province I-ORG Grant O No. O 2016HH0052,http://www.scst.gov.cn B-AWARD Recipient O M.L O and O the O China B-ORG Agricultural I-ORG Research I-ORG System I-ORG CARS-42-17,http://www.moa.gov.cn O Recipient O A.C O The O funders O M.L O and O A.C O had O a O role O in O study O design O decision O to O publish O and O perparation O of O the O manuscript O Financial O support O came O from O the O Swiss B-ORG National I-ORG Foundation I-ORG 310030_140691/1 O VTH O the O EVIMalaR B-ORG EU I-ORG network I-ORG FP7/2007–2013 O CAN O and I-ORG VTH O FP7/2014–2015 O RW) O and O the O Novartis O Foundation O for O Medical-Biomedical O Research O CAN O and O VTH O The O work O in O the O Hamada O laboratory O was O supported O by O grants O from O CREST O Core O Research I-ORG for I-ORG Evolutional I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG the I-ORG Japan I-ORG Science I-ORG and I-ORG Technology I-ORG Corporation O 17H01435 O and O the O Ministry B-ORG of I-ORG Education I-ORG Culture I-ORG Sports I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Japan I-ORG 18K14725 O PPLT O is O a O Senior O Principal O Research O Fellow O of O the O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG of I-ORG Australia I-ORG NHMRC O grant O 1003100 B-AWARD This O work O was O funded O in O part O by O grants O from O the O Utah B-ORG Science I-ORG Technology I-ORG and I-ORG Research I-ORG A34637 O and O A36815 B-AWARD and O by O a O grant O from O the O American O Board O of O Obstetrics O and O Gynecology O the O American O College O of O Obstetricians O and O Gynecologists O the O American B-ORG Society I-ORG for I-ORG Reproductive I-ORG Medicine O and O the O Society O for O Reproductive O Endocrinology O and O Infertility O 200784-00001 O This O research O was O also O supported O by O the O Utah B-ORG Agricultural I-ORG Experiment I-ORG Station I-ORG UTA01345 O and O approved O as O journal O paper O number O 8929 O The O design O and O collection O and O data O analysis O of O the O study O were O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFC1000102 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81573165 B-AWARD and O No. O 81970738 B-AWARD Special B-ORG Foundation I-ORG for I-ORG State I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG No. O 2014FY110700 B-AWARD and O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2020YFS0071 O This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Grant O Nos O 2018YFC2001600 B-AWARD and O 2018YFC2001604 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 81802249 B-AWARD 81871836 B-AWARD 81874035 B-AWARD and O 81902301 B-AWARD the O Shanghai B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Grant O No. O 2018YQ02 B-AWARD the O Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Committee I-ORG Grant O No. O 22010504200 B-AWARD the O Shanghai B-ORG Rising-Star I-ORG Program I-ORG Grant O No. O 19QA1409000 B-AWARD and O the O Shanghai B-ORG Youth I-ORG Top I-ORG Talent I-ORG Development I-ORG Plan I-ORG Shanghai I-ORG “Rising I-ORG Stars I-ORG of I-ORG Medical I-ORG Talent” I-ORG Youth I-ORG Development I-ORG Program I-ORG Program I-ORG of I-ORG Shanghai I-ORG Academic I-ORG Research I-ORG Leader I-ORG Grant O No. O 19XD1403600 B-AWARD This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O China O 2016A030313207 O and O 2017A030313889 B-AWARD This O study O was O partly O supported O by O the O Guangzhou B-ORG Science I-ORG Technology I-ORG and I-ORG Innovation I-ORG Commission I-ORG 201604020008 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81772368 O This O work O was O supported O by O grants O from O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2022YFA1103500 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82222003 O 92268117 O 82161138028 O the B-ORG Zhejiang I-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG LR19H080001 O and O the B-ORG Zhejiang I-ORG Innovation I-ORG Team I-ORG Grant I-ORG 2020R01006 O This O work O was O supported O by O the O Programa B-ORG de I-ORG Apoyo I-ORG a I-ORG Proyectos I-ORG de I-ORG Investigación I-ORG e I-ORG Innovación I-ORG Tecnológica I-ORG UNAM-PAPIIT-DGAPA O grant O number O IN217721 B-AWARD and O Consejo B-ORG Nacional I-ORG de I-ORG Ciencia I-ORG y I-ORG Tecnología I-ORG CONACyT O México O grant O number O Ciencia B-AWARD de I-AWARD Frontera I-AWARD 2019-171880 O MH-C O received O fellowship O grant O number O 1035418 B-AWARD from O CONACYT B-ORG for O MSc O studies O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 31620103916 B-AWARD and O 31772492 B-AWARD the B-ORG Strategic I-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG No. O XDA19050303 B-AWARD the B-ORG Youth I-ORG Innovation I-ORG Promotion I-ORG Association I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG No. O 2020087 B-AWARD and O the B-ORG Second I-ORG Tibetan I-ORG Plateau I-ORG Scientific I-ORG Expedition I-ORG and I-ORG Research I-ORG STEP I-ORG program I-ORG No. O 2019QZKK0601 B-AWARD This O study O was O financially O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31301972 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Province I-ORG 1308085QC66 O Educational B-ORG Commission I-ORG of I-ORG Anhui I-ORG Province I-ORG kj2013A081 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Universities I-ORG of I-ORG Anhui I-ORG Province I-ORG kj2016A823 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O in O part O by O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 I-ORG Program I-ORG under O Grant O 2014CB748600 B-AWARD http://www.nsfc.gov.cn O XC) O and O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC I-ORG under O Grants O 81371629 B-AWARD 81401472 I-AWARD 61401294 I-AWARD 61401293 I-AWARD 61622114 I-AWARD http://www.nsfc.gov.cn O XC O and O in O part O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Jiangsu I-ORG Province I-ORG under O Grant O BK20140052 B-AWARD http://www.jstd.gov.cn O XC O This O work O was O supported O by O the O Special B-ORG Fund I-ORG for I-ORG Agro-scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG 201303088 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31271988 O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province(BE2014738 O Special B-ORG Fund I-ORG for I-ORG Risk I-ORG Assessment I-ORG of I-ORG China I-ORG GJFP201500702 O Jiangsu B-ORG Agriculture I-ORG Science I-ORG and I-ORG Technology I-ORG CX(14)2126 B-AWARD The B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81630019 B-AWARD 81870519 B-AWARD and O 81802827 B-AWARD Scientific B-ORG Research I-ORG Foundation I-ORG of I-ORG the I-ORG Institute I-ORG for I-ORG Translational I-ORG Medicine I-ORG of I-ORG Anhui I-ORG Province I-ORG 2017ZHYX02 O The O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O China O 2017A030313800 O Shenzhen O Basic O Research O Project O JCYJ20160429172247015 O This O study O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC0116500 O the O NSFC B-ORG No. O 91546101 B-AWARD 61472311 B-AWARD and O 11401454 O the O Guangdong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O YQ2015006 B-AWARD No. O 2014A030306030 O No. O 2014TQ01R573 B-AWARD No. O 2013B020400003 B-AWARD the O Natural O Science O Foundation O of O Guangzhou O City O No. O 2014J2200060 O the O State O Key O Laboratory O of O Ophthalmology O Zhongshan O Ophthalmic O Center O Sun O Yat-sen O University O No. O 2015ykzd11 O No. O 2015QN01 O the O Special O Program O for O Applied O Research O on O Super O Computation O of O the O NSFC-Guangdong O Joint O Fund O the O second O phase O and O the O Clinical O Research O and O Translational O Medical O Center O for O Pediatric O Cataract O in O Guangzhou O City O the O Fundamental O Research O Funds O for O the O Central O Universities O No. O BDZ011401 O BDZ011401 O and O JB151005 O and O the O National O Defense O Basic O Research O Project O of O China O jcky2016110c006 O This O work O was O supported O by O the O University B-ORG of I-ORG Florence I-ORG Fondo O Ricerca O Ateneo O RICATEN17 B-AWARD and O RICATEN18 B-AWARD MIUR-FIRB B-ORG Grant O RBFR12SOQ1_003 B-AWARD and O 004 B-AWARD and O Italian B-ORG Association I-ORG for I-ORG Cancer I-ORG Research I-ORG Grant O IG21408 B-AWARD JL O acknowledges O partial O support O by O National B-ORG Science I-ORG Foundation I-ORG grant O NSF-DMS-1714973 B-AWARD National B-ORG Institutes I-ORG of I-ORG Health I-ORG Grant O P50GM76516 B-AWARD for O the O Center O of O Excellence O in O Systems O Biology O at O the O University O of O California O Irvine O and O National O Institutes O of O Health O Grant O P30CA062203 B-AWARD for O the O Chao O Family O Comprehensive O Cancer O Center O at O University O of O California O Irvine O HBF O acknowledges O partial O support O by O the O National O Institutes O of O Health/National O Cancer I-ORG Institute I-ORG Grant O R15CA203605 B-AWARD This O research O was O funded O by O the O Agencia B-ORG Estatal I-ORG de I-ORG Investigación I-ORG and I-ORG Fondos I-ORG FEDER I-ORG grant O RTI2018-098711-B-100 B-AWARD the O Gobierno B-ORG de I-ORG Aragón I-ORG consolidated I-ORG research I-ORG group I-ORG A19-20R B-AWARD and O the O Gobierno B-ORG de I-ORG Aragón I-ORG and I-ORG the I-ORG European I-ORG Social I-ORG Fund I-ORG co-financed O predoctoral O grant O Order O IIU/2023/2017 B-AWARD This O work O was O supported O by O intramural O research O funds O of O the O Medical O Faculty O of O the O University B-ORG of I-ORG Duisburg-Essen I-ORG IFORES O to O JK, O by O the O Deutsche B-ORG Forschungsgemeinschaft I-ORG RU O 742/6-1 I-AWARD to O CR) O and O the O Faculty B-ORG of I-ORG Medicine I-ORG of I-ORG the I-ORG University I-ORG of I-ORG Munich O LMU O FöFoLe O 905 I-AWARD to O SH O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG under O Grant O No. B-AWARD LY21H200001 I-AWARD and O No. B-AWARD Q21H160017 O Project B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. B-AWARD 2022500399 O Pioneer O and O lead O goose O of O R&D O program O of O Zhejiang O Grant O No. O 2022C03002 O Zhejiang B-ORG province I-ORG public I-ORG welfare I-ORG technology I-ORG application I-ORG research I-ORG project I-ORG No. B-AWARD 2020KY058 O No. O 2020KY067 O and O No. B-AWARD 2021KY082 O Scientific O research O start-up O fund O for O talents O of O Zhejiang O Cancer O Hospital O at O the O fifth O level O The O authors O would O like O to O acknowledge O the O financial O support O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No.51604024 O 51975043 O the O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O No.3182026 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No. O FRF-TP-19-002A3 B-AWARD This O research O was O funded O by O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82260843 O 82160812 B-AWARD and O 82060649 B-AWARD Guizhou B-ORG Engineering I-ORG Research I-ORG Center I-ORG of I-ORG Industrial I-ORG Key-technology I-ORG for I-ORG Dendrobium I-ORG Nobile I-ORG QJJ O 2022]048 O and O the O Department B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Guizhou I-ORG Province I-ORG QKHZC O 2019]2953 O This O work O was O financially O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O Grant O No. O 52005203 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No. O 2662022GXQD002 B-AWARD and O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2019M662600 B-AWARD This O work O was O supported O by O the O Italian B-ORG Ministry I-ORG for I-ORG University I-ORG and I-ORG Research I-ORG MUR O under O AVATAR O X O project O No. O POC01_00111 B-AWARD by O the O European B-ORG Union I-ORG EU) O under O the O project—FESR O o O FSE O PON O Ricerca O e O Innovazione O 2014–2020—DM O 1062/2021 I-AWARD and O FFR2023 B-AWARD and O by O BIOMONTANS O project O funded O by O CARIPARMA B-ORG This O work O has O been O funded O by O the O German O Research O Foundation O Deutsche O Forschungsgemeinschaft)(grant O No O WO B-AWARD 1746/1-2 O MW O received O this O funding O This O work O was O also O supported O by O the O Innovative B-ORG Medicines I-ORG Initiative I-ORG Joint O Undertaking O resources O composed O of O financial O contribution O from O the O European O Union’s O Seventh O Framework O Programme O FP7/2007-2013 O and O EFPIA O companies O grant O number O 115737-2 B-AWARD – O COMBACTE-MAGNET O and O 115523 B-AWARD – O COMBACTE-NET B-ORG The O funding O bodies O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O The O article O processing O charge O was O funded O by O the O German O Research O Foundation O DFG O and O the O Albert O Ludwigs O University O Freiburg O in O the O funding O programme O Open O Access O Publishing O This O study O is O funded O by O the O British B-ORG Heart I-ORG Foundation I-ORG SP/07/008/24066 O Wellcome B-ORG WT092830M O wellcome.ac.uk O and O the O UK B-ORG Medical I-ORG Research I-ORG Council I-ORG G1001357 O ALSPAC O receives O core O funding O from O the O University O of O Bristol O Wellcome O and O the O UK O Medical O Research O Council O 102215/2/13/2 O MAK O receives O funding O from O the O Sigrid O Juselius O Foundation O Finland O DLSF O MAK O and O DAL O work O in O a O unit O that O receives O funds O from O the O University O of O Bristol O and O the O UK O Medical O Research O Council O MC_UU_12013/1 O and O MC_UU_12013/5 O DAL O is O a O senior O investigator O for O the O National O Institute O for O Health O Research O NF-SI-0611–10196 O The O funders O had O no O role O in O designing O the O study O collecting O or O analyzing O the O data O or O writing O the O paper O The O views O expressed O in O this O paper O are O those O of O the O authors O and O not O necessarily O any O funding O body O This O research O was O supported O by O Miloca B-ORG and I-ORG Zoo I-ORG de I-ORG Barcelona I-ORG PRIC-2011 O SC O is O supported O by O a O CGL2015-70390-P B-AWARD from O the O Ministerio B-ORG de I-ORG Economía I-ORG y I-ORG Competitividad I-ORG Spain I-ORG cofunded O by O FEDER O and O grant O 2014-SGR-1532 B-AWARD from O the O Secretaria B-ORG d’Universitats I-ORG i I-ORG Recerca I-ORG del I-ORG Departament I-ORG d’Economia I-ORG i I-ORG Coneixement I-ORG de I-ORG la I-ORG Generalitat I-ORG de I-ORG Catalunya O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Xin O Zhou O was O supported O by10.13039/501100001809National O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China[61475104 O 61177009 B-AWARD Yanzhi O Bai O was O supported O by10.13039/501100001809National O Natural O Science O Foundation O of O China[52004159 O Chao O Han O were O supported O by10.13039/501100001809National O Natural O Science O Foundation O of O China[U22A2079],10.13039/501100014762Anhui O Polytechnic I-ORG University[DTESD O 2020A06 O Dongming O Huo O was O supported O by10.13039/501100010814Anhui O Provincial I-ORG Department I-ORG of I-ORG Education[KJ2020 O A0346],10.13039/501100014762Anhui O Polytechnic O University[Xjky2022047 O 2019 B-AWARD YQQ007 O Lisheng O Wei O was O supported O by10.13039/501100010814Anhui O Provincial O Department O of O Education[KJ2020 O ZD39],10.13039/501100014762Anhui O Polytechnic O University[DTESD O 2020A02 O This O work O was O supported O by O grant O No. O 71371167 B-AWARD from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG http://www.nsfc.gov.cn O grant O No. O AWS12J003 B-AWARD from O the O National B-ORG Project I-ORG and O grant O No. O 2017A030310466 B-AWARD from O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG http://www.gdstc.gov.cn O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O European B-ORG Research I-ORG Council I-ORG under O the O European O Union's O Seventh O Framework O Programme O FP7/2007-2013 O O ERC O grant O agreement O n°293948 O P.B.B.),https://erc.europa.eu O P.B O is O supported O by O the O Emmy B-ORG Noether I-ORG Program I-ORG BE O 5342/1-1 O from O the O German O Research O Foundation,http://www.dfg.de/foerderung/programme/einzelfoerderung/emmy_noether/and O the O Marie B-ORG Curie I-ORG Career I-ORG Integration I-ORG Grant I-ORG from I-ORG the I-ORG European I-ORG Commission I-ORG 630763),http://ec.europa.eu/research/mariecurieactions/funded-projects/career-integration-grants_en O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O in O part O by O the O project B-ORG of I-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG development I-ORG No. O 2019YFC0408504 B-AWARD Natural B-ORG Science I-ORG Research I-ORG Project I-ORG of I-ORG Anhui I-ORG Educational I-ORG Committee I-ORG No. O 2022AH040046 B-AWARD KJ2019A0772 B-AWARD Quality B-ORG engineering I-ORG project I-ORG of I-ORG colleges I-ORG and I-ORG universities I-ORG in I-ORG Anhui I-ORG Province I-ORG No. O 2020kfkc263 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Province I-ORG No. O 2008085MB44 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 12272351 B-AWARD the O Youth B-ORG Top-notch I-ORG Talent I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Ten I-ORG Thousand I-ORG Plan I-ORG of I-ORG China I-ORG No. O ZJWR0308010 B-AWARD and O the O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O LR19E020004 B-AWARD and O LR20A020002 B-AWARD This O work O was O supported O by O grants O MOST104-2320-B-037-032-MY2 B-AWARD from O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Taiwan I-ORG Taipei I-ORG Taiwan O National B-ORG Health I-ORG Research I-ORG Institutes I-ORG of I-ORG Taiwan I-ORG NHRI-105A1-PDCO-0316164 O and O KMU-M104011 B-AWARD from O Kaohsiung B-ORG Medical I-ORG University I-ORG Kaohsiung I-ORG Taiwan O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG China I-ORG 2019YFC1407805 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41876134 O 41676112 I-AWARD and I-AWARD 41276124 O the O Key O Project O of O Natural O Science O Foundation O for O Tianjin O 17JCZDJC40000 O the O University O Innovation O Team O Training O Program O for O Tianjin O TD12-5003 O the O Tianjin O 131 O Innovation O Team O Program O 20180314 O and O the O Changjiang B-ORG Scholar I-ORG Program I-ORG of I-ORG Chinese I-ORG Ministry I-ORG of I-ORG Education I-ORG T2014253 O to O Jun O Sun O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31501292 O Major B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Henan I-ORG Province I-ORG 141100110600 O the O Support B-ORG Plan I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Team I-ORG in I-ORG Universities I-ORG of I-ORG Henan I-ORG province I-ORG 17IRTSTHN015 O and O Key B-ORG Scientific I-ORG Research I-ORG Project I-ORG in I-ORG Universities I-ORG of I-ORG Henan I-ORG Province I-ORG 16A210009 O This O work O was O supported O by O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Pillar I-ORG Program I-ORG during O the O 12th O Five-year O Plan O Period O 2014BAD05B04-4 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31501696 O and O 31471831 B-AWARD the O Agriculture B-ORG Research I-ORG System I-ORG of I-ORG China I-ORG CARS-25-B-05 O and O the O Innovation B-ORG Platform I-ORG and I-ORG Talent I-ORG Plan I-ORG 2016RS2019 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O by O four O research O grants O including O China’s B-ORG Natural I-ORG Science I-ORG Fund I-ORG #31460592 O China’s B-ORG Agricultural I-ORG Research I-ORG system I-ORG CARS-39-18 O Agro-scientific B-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG 201503134 O and O Gansu B-ORG Academy I-ORG of I-ORG Agricultural I-ORG Science I-ORG Fund I-ORG 2017GAAS30 O All O of O these O funds O were O from O Chinese O government O The O funder O provided O support O in O the O form O of O research O materials O and O did O not O have O any O additional O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O author O David O P O Casper O analysed O data O and O corrected O the O manuscript O Furst-McNess O Company O didn’t O apply O any O financial O support O for O the O present O study O in O the O form O of O authors’ O salaries O and/or O research O materials O This O research O was O funded O by O the O Heart B-ORG Foundation I-ORG of I-ORG New I-ORG Zealand I-ORG #1562 O 1879 B-AWARD the O Health B-ORG Research I-ORG Council I-ORG of I-ORG New I-ORG Zealand I-ORG #14/521 O 11/170 B-AWARD 17/562 B-AWARD Lotteries B-ORG Health I-ORG Research I-ORG #R-LHR-2017-49246 O and O the O Christchurch O Heart O Institute O Trust O E.M.T O was O supported O by O a O University O of O Otago O Postgraduate O Scholarship O M.L O was O supported O by O the O Heart O Foundation O of O New O Zealand O #1693 O and O the O Farina O Thompson O Charitable O Trust O N.J.A.S O was O supported O by O the O Heart O Foundation O of O New O Zealand O grant O 1736 B-AWARD and O the O Canterbury B-ORG Medical I-ORG Research I-ORG Foundation I-ORG grant O 2017PRONicola B-AWARD Scott O A.M.R O holds O the O Heart O Foundation O New O Zealand O Chair O of O Cardiovascular O Studies O A.P.P O holds O the O Heart O Foundation O New O Zealand O Foundation100 O Fellowship O This O research O was O funded O by O the O National B-ORG Institute I-ORG of I-ORG Diabetes I-ORG and I-ORG Digestive I-ORG and I-ORG Kidney I-ORG Diseases I-ORG grant O 1D01DK080906 B-AWARD to O M.T.K O the O Uniformed B-ORG Services I-ORG University I-ORG of I-ORG the I-ORG Health I-ORG Sciences I-ORG grant O R072IC B-AWARD to O M.T.K O and O the O Intramural O Research O Program O Eunice B-ORG Kennedy I-ORG Shriver I-ORG National I-ORG Institute I-ORG of I-ORG Child I-ORG Health I-ORG and I-ORG Human I-ORG Development O NIH O grant O IZIAHD000641 B-AWARD to O J.A.Y O This O research O was O supported O in O part O by O three O grants O the O first O Next-Generation B-ORG BioGreen21 I-ORG Program I-ORG PJ01104501 O grant O played O a O role O in O design O of O the O study O the O second O Cooperative B-ORG Research I-ORG Program I-ORG for I-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Project O No. O PJ01168501 B-AWARD of O Rural O Development O Administration O grant O helped O in O collection O analysis O and O interpretation O of O the O data O and O the O third O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF I-ORG grant I-ORG funded O by O the O Korea O government O MSIP O No. O 2015R1A2A1A10051668 B-AWARD Republic O of O Korea O supported O in O writing O the O manuscript O This O work O was O supported O by O the B-ORG Major I-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31590820 O 31590823 B-AWARD Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Grant O No. O XDA20050000 B-AWARD and O the B-ORG Natural I-ORG Science I-ORG foundation I-ORG of I-ORG Yunnan I-ORG Province I-ORG 2017FB050 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61703152 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG No. O 2018JJ3134 B-AWARD 2019JJ50127 O 2016JJ4010 O Scientific B-ORG Research I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Provincial I-ORG Education I-ORG Department I-ORG 18A273 O 18C0522 O and O Project O of O Science O and O Technology O Plan O in O Zhuzhou O 201707201806 O Project O of O Science O and O Technology O Department O of O Hunan O Province O GD16K02 O Project O of O Hengyang O Normal O University O HXKJ201912 O Foundation O of O Key O Laboratory O of O Functional O Organometallic O Materials O University O of O Hunan O Province O GN19K01 O GN19K05 O and O Foundation O of O Key O Laboratory O of O Functional O Metal-Organic O Compounds O of O Hunan O Province O MO19K08 O The O project O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 11602169 O 11832002 B-AWARD 11702192 B-AWARD 11772218 O and O 11872044 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Tianjin I-ORG City I-ORG 16JCQNJC04700 O and O 17JCYBJC18900 O and O Scientific B-ORG Research I-ORG Project I-ORG of I-ORG Tianjin I-ORG Municipal I-ORG Education I-ORG Commission I-ORG 2017KJ262 O This O study O was O supported O by O the O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG 973 O Program O no. O 2014CB744505 B-AWARD to O X.Y O Key B-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 81430040 B-AWARD to O X.Y O General B-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 81571738 B-AWARD to O J.S O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG no. O 2016YFA0100900 B-AWARD to O J.S O and O Medical B-ORG and I-ORG Health I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Province I-ORG nos O 2016146039 B-AWARD and O 2017209189 B-AWARD to O M.Z O This O study O is O funded O by O a O grant O from O the O Prince B-ORG of I-ORG Songkla I-ORG University I-ORG grant O number O MED590692S B-AWARD the B-ORG Research I-ORG Center I-ORG for I-ORG Cancer I-ORG Control I-ORG in I-ORG Thailand I-ORG grant O number O MEDRC59036 B-AWARD and O the O Faculty B-ORG of I-ORG Medicine I-ORG Prince I-ORG of I-ORG Songkla I-ORG University I-ORG grant O number O REC60350042 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Jeffrey O Glennon O FP7 B-ORG Ideas I-ORG European I-ORG Research I-ORG Council O Award O ID: O 305697 B-AWARD OPTIMISTIC O Jeffrey O Glennon O European B-ORG Community’s I-ORG Seventh I-ORG Framework I-ORG Programme I-ORG FP7/2007-2013 O Award O ID: O 278948 B-AWARD TACTICS O Jeffrey O Glennon O European B-ORG Union’s I-ORG Seventh I-ORG Framework I-ORG Programme O Award O ID: O 603016 B-AWARD MATRICS O Christian O Beckmann O Wellcome B-ORG Trust I-ORG UK I-ORG Strategic I-ORG Award O Award O ID: O 098369/Z/12/Z B-AWARD Christian O Beckmann O Netherlands B-ORG Organization I-ORG for I-ORG International I-ORG Cooperation I-ORG in I-ORG Higher I-ORG Education I-ORG NL) I-ORG Netherlands I-ORG Organisation I-ORG for I-ORG Scientific I-ORG Research I-ORG NWO-Vidi O Award O ID: O 864-12-003 B-AWARD The O project O was O funded O by O the B-ORG Western I-ORG Area I-ORG Health I-ORG Initiative I-ORG WAHI O WPCHN1408195 O Chongqing B-ORG Social I-ORG Science I-ORG Planning I-ORG Project I-ORG 2013QNL50 O and O Medical B-ORG Research I-ORG Program I-ORG of I-ORG Chongqing I-ORG City I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Committee I-ORG 2013-2-153 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFA0504000 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 91940302 O 31500644 B-AWARD 31570792 B-AWARD 31822015 B-AWARD 81870896 B-AWARD 31670801 B-AWARD Strategic O Priority O Research O Program O of O the O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG XDB19010203 O Shanghai O Key O Laboratory O of O Embryo O Original O Diseases O Shelab201904 O Funding O for O open O access O charge O Natural O Science O Foundation O of O China O 31670801 O 31822015 O This O work O was O financially O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0504302-01 O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Ningxia I-ORG Hui I-ORG Autonomous I-ORG Region I-ORG China I-ORG grant O no O 2018BBF02021 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O nos O 41771105 B-AWARD and O 41401112 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O SK O was O supported O by O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH O R01GM126567-01 B-AWARD National B-ORG Science I-ORG Foundation I-ORG ABI O 1661218 O National B-ORG Aeronautics I-ORG and I-ORG Space I-ORG Administration I-ORG NASA O NNX16AJ30G B-AWARD Pennsylvania B-ORG Department I-ORG of I-ORG Health I-ORG TU-420721 O KT O was O supported O by O Tokyo B-ORG Metropolitan I-ORG University I-ORG DB105 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31471232 O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Projects I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2014B030301040 O Major B-ORG Program I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Guangzhou I-ORG 201607020001 O to O ZX; O Joint B-ORG Research I-ORG Fund I-ORG for I-ORG Overseas I-ORG Natural I-ORG Science I-ORG of I-ORG China I-ORG 3030901001222 O to O WL O and O ZX; O also O supported O by O National O Natural O Science O Foundation O of O China O 3030901001215 O to O YMW O This O study O was O supported O by O grants O from O the O Key B-ORG Clinic I-ORG Medicine I-ORG Research I-ORG Program I-ORG the I-ORG Ministry I-ORG of I-ORG Health I-ORG China I-ORG 201302015 O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Program I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG China I-ORG 2012BAI08B01 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81170817 O 81200658 I-AWARD 81300735 I-AWARD 81270978 I-AWARD U1205025 I-AWARD and I-AWARD 81330022 O the O Scientific B-ORG Research I-ORG Program I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG Shanghai I-ORG 13441900900 O 13430720400 O and O the O New B-ORG Technology I-ORG Joint I-ORG Research I-ORG Project I-ORG in I-ORG Shanghai I-ORG Hospitals I-ORG SHDC12014114 O The O sponsors O or O funding O organizations O had O no O role O in O the O design O or O conduct O of O this O research O This O research O was O supported O by O China B-ORG Energy I-ORG SHGF-17-56-9 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG of I-ORG China I-ORG 2016YFB1200402 O and O the O Research B-ORG of I-ORG National I-ORG Railway I-ORG Administration I-ORG of I-ORG China I-ORG AJ2019-033 O National B-ORG Institute I-ORG of I-ORG Environmental I-ORG Health I-ORG Sciences O United O States O National O Institutes O of O Health O ES015558 O JT O the O Thrasher B-ORG Research I-ORG Fund I-ORG 02830-4 O JT O and O the O Global O Alliance O for O Clean O Cookstoves O of O the O United B-ORG Nations I-ORG Foundation I-ORG UNF-12-380 O JT O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-10 O Sweetpotato O the O Modern B-ORG Agriculture I-ORG Industrial I-ORG Technology I-ORG System I-ORG Innovation I-ORG Team I-ORG Project I-ORG of I-ORG Hebei I-ORG Province I-ORG HBCT2018080203 O Key B-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG Hebei I-ORG Province I-ORG 19226338D O the O Modern B-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG Hebei I-ORG Province I-ORG 2019-4-2-7 O and O the O Science B-ORG and I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG Project I-ORG of I-ORG Hebei I-ORG Academy I-ORG of I-ORG Agricultural I-ORG and I-ORG Forestry I-ORG Sciences I-ORG 2018060305 O The O funding O bodies O were O not O involved O in O the O design O of O the O study O in O the O collection O analysis O and O interpretation O of O data O or O in O writing O the O manuscript O This O study O is O supported O by O Yunling B-ORG Scholar I-ORG 2015 B-AWARD No. I-AWARD 56, O Yunling B-ORG Technology I-ORG Leading I-ORG Talent I-ORG 2014 B-AWARD No. I-AWARD 1782 O Applied B-ORG Basic I-ORG Research I-ORG Foundation I-ORG of I-ORG Yunnan I-ORG Province I-ORG No. O 2016FD018 B-AWARD and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31660304 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81202220 B-AWARD to O Y. O Z O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province O China O No. O BK20150094 B-AWARD to O Q. O Z O and O by O the O Chongqing B-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG No. O 20141027 B-AWARD to O H. O X O The O funders O had O no O role O in O the O study O design O data O collection O data O analysis O data O interpretation O or O writing O of O the O report O The O corresponding O authors O had O full O access O to O all O the O data O in O the O study O and O had O final O responsibility O for O the O decision O to O submit O for O publication O This O work O was O supported O by O The O National B-ORG Natural I-ORG Science I-ORG Fund I-ORG of I-ORG China I-ORG 81570375 O The B-ORG Scientific I-ORG and I-ORG Technological I-ORG Project I-ORG of I-ORG Tianjin I-ORG Binhai I-ORG New I-ORG Area I-ORG Health I-ORG Committee I-ORG 2017BWKY036 O and O The B-ORG Incubation I-ORG Fund I-ORG Project I-ORG of I-ORG Tianjin I-ORG Medical I-ORG University I-ORG General I-ORG Hospital I-ORG ZYYFY2016021 O This O work O was O supported O by O Italian B-ORG Ministry I-ORG of I-ORG University I-ORG FISR2019_00374 B-AWARD MeDyCa I-AWARD A.M O “Sapienza” B-ORG Ateneo I-ORG Project I-ORG 2021 I-ORG n. B-AWARD RM12117A61C811CE I-AWARD D.R O Regione B-ORG Lazio I-ORG PROGETTI I-ORG DI I-ORG GRUPPI I-ORG DI I-ORG RICERCA I-ORG 2020-A0375-2020-36597 O D.R O F.F O is O supported O by O the O E.U.’s B-ORG Horizon I-ORG Europe I-ORG program I-ORG under I-ORG the I-ORG Marie I-ORG Skłodowska-Curie I-ORG grant I-ORG agreement I-ORG EpiPolyPharma I-ORG 101062363 B-AWARD This O research O was O funded O by O the O Central B-ORG Government I-ORG Guided I-ORG Local I-ORG Scientific I-ORG and I-ORG Technological I-ORG Development I-ORG Project O China O grant O no. O 2021ZY0015 B-AWARD the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Applied I-ORG Optics I-ORG Project O China O grant O no. O SKLA02020001A19 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Young I-ORG Talents I-ORG Development I-ORG Project I-ORG of I-ORG Inner I-ORG Mongolia I-ORG Autonomous I-ORG Region O China O grant O no. O NJYT22048 B-AWARD This O study O was O funded O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81672959 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Chongqing O China O No. O cstc2015shmszx120019 O and O the O Graduate B-ORG Student I-ORG Research I-ORG Innovation I-ORG Project I-ORG of I-ORG Chongqing O China O No. O CYS15127 O This O study O was O supported O by O grants O from O the B-ORG Science I-ORG and I-ORG technology I-ORG project I-ORG in I-ORG Wuhu I-ORG NO.2013cxy04 O Anhui B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG to O Yao O Zhang O NO.1508085MH149 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO.81200632 O This O research O was O supported O by O grants O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG No. O 2016YFD0101004 B-AWARD and O 2016YFD0102001-004 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Major O Program O No. O 91935304 O the O International O Cooperation O and O Exchange O of O the O National O Natural O Science O Foundation O of O China O No. O 31661143005 O the O National O Natural O Science O Foundation O of O China O No. O 31971943 B-AWARD the O special O fund O of O Jiangsu O Province O for O the O transformation O of O scientific O and O technological O achievements O No. O BA2017138 O the O Program B-ORG of I-ORG Introducing I-ORG Talents I-ORG of I-ORG Discipline I-ORG to I-ORG Universities I-ORG No. O B08025 B-AWARD the O Creation O of O Major O New O Agricultural O Varieties O in O Jiangsu O Province O No. O PZCZ201706 O the O Jiangsu O Agricultural O Technology O System O JATS O No. O JATS O 2019 O 429 O and O the O Key O Research O and O Development O Major O Project O of O Ningxia O Autonomous O Region O No. O 2019BBF02022-04 O This O work O was O supported O by O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32272898 O 31902189 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG 2021CFB436 O 2021CFA018 B-AWARD Knowledge B-ORG Innovation I-ORG Program I-ORG of I-ORG Wuhan-Shuguang I-ORG Project I-ORG 2022020801020230 O and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2662022YJ003 O 2662020DKQD004 B-AWARD This O work O was O supported O by O Chinese B-ORG Cassava I-ORG Agro-technology I-ORG Research I-ORG System I-ORG CARS-11-YNSJ O Yunnan B-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Biological I-ORG Big I-ORG Data I-ORG 2018DG024 O and O the O Science B-ORG and I-ORG Technology I-ORG Plan I-ORG Projects I-ORG of I-ORG Yunnan I-ORG Province I-ORG 2016FD024 O J. O Lin O acknowledges O the O financial O support O provided O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 52108251 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG E2021203141 O and O the O open B-ORG research I-ORG fund I-ORG of I-ORG Jiangsu I-ORG Key I-ORG Laboratory I-ORG of I-ORG Construction I-ORG Materials I-ORG Southeast I-ORG University I-ORG 202203 O H. O Chen O is O grateful O for O the O financial O support O from O the O National O Natural O Science O Foundation O of O China O 51878152 O and O 52278246 B-AWARD M. O Li O is O grateful O for O the O financial O support O from O the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Hebei I-ORG Education I-ORG Department I-ORG BJK2023053 O and O Tianjin B-ORG Education I-ORG Commission I-ORG Scientific I-ORG Research I-ORG Project I-ORG 2022KJ100 O L. O Yuan O is O very O grateful O for O the O financial O support O from O Shenzhen B-ORG Science I-ORG and I-ORG technology I-ORG R I-ORG I-ORG D I-ORG fund I-ORG support O project O JSGG20210802152541012 O This O research O was O sponsored O by O the O National B-ORG Key I-ORG R I-ORG I-ORG D I-ORG Plan I-ORG of I-ORG China I-ORG Nos O 2017YFD0200900 B-AWARD 2016YFD0300700 B-AWARD and O 2017YFD0201700 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 31871966 B-AWARD and O 31871979 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2018M631646 B-AWARD the O State O Modern B-ORG Agricultural I-ORG Industry I-ORG Technology I-ORG System I-ORG No. O CARS-22-G-18 B-AWARD and O the O China B-ORG Scholarship I-ORG Council I-ORG No. O 201703250048 B-AWARD This O work O was O jointly O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0500104 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31470260 O 81401672 B-AWARD and O 81660558 B-AWARD and O the O Hu-Xiang B-ORG Youth I-ORG Talents I-ORG Scholar I-ORG Program I-ORG of I-ORG Hunan I-ORG Province I-ORG 2017RS3017 O This O research O was O funded O in O part O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O No. O 62271250 B-AWARD in O part O by O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province O No. O BK20211182 B-AWARD in O part O by O the B-ORG open I-ORG research I-ORG fund I-ORG of I-ORG the I-ORG National I-ORG Mobile I-ORG Communications I-ORG Research I-ORG Laboratory I-ORG Southeast I-ORG University O No. O 2022D04 B-AWARD and O in O part O by O the B-ORG Key I-ORG Technologies I-ORG R&D I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Prospective O and O Key O Technologies O for O Industry O under O Grants O BE2022067 B-AWARD and O BE2022067-2 B-AWARD This O work O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grants O 61571445 B-AWARD and O 81601636 B-AWARD the O Major B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG Shaanxi I-ORG Province I-ORG of I-ORG China I-ORG under O Grant O 2016ZDJC14 B-AWARD the B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shaanxi I-ORG Province I-ORG of I-ORG China I-ORG under O Grant O 2018KW-060 B-AWARD the O Equipment B-ORG Science I-ORG Research I-ORG Project I-ORG under O Grant O 2016ZBKY02 B-AWARD and O the O Research B-ORG Program I-ORG of I-ORG the I-ORG Fourth I-ORG Military I-ORG Medical I-ORG University I-ORG under O Grants O 2016TSB016 B-AWARD and O 2017XB005 B-AWARD Major O military O research O projects O of O PLA O under O Grants O ALJ17J001 O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51978347 B-AWARD the B-ORG Shandong I-ORG Province I-ORG Agricultural I-ORG Major I-ORG Application I-ORG Technology I-ORG Innovation I-ORG Project I-ORG No. O 20182130106 B-AWARD and O the B-ORG Shandong I-ORG Province I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG No. O 2018GSF117005 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81871445 B-AWARD 81801788 B-AWARD 81603705 B-AWARD 81674084 B-AWARD 81874509 B-AWARD the O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2015CB554502 B-AWARD KKC O is O supported O by O Flagship B-ORG Research I-ORG University I-ORG Grant I-ORG from I-ORG Universiti I-ORG Teknologi I-ORG Malaysia I-ORG R.J130000.2446.03G58 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Granted O No. O 41771420,http://www.nsfc.gov.cn B-AWARD National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG Granted O No. O 2016YFE0131600,http://www.most.gov.cn B-AWARD Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG Granted O No.164320H116,http://www.jstd.gov.cn O Project B-ORG of I-ORG Natural I-ORG Science I-ORG Research I-ORG in I-ORG Colleges I-ORG and I-ORG Universities I-ORG in I-ORG Jiangsu I-ORG Province I-ORG Granted O No. O 18KJB170007,http://www.jstd.gov.cn B-AWARD Postgraduate B-ORG Research I-ORG I-ORG Practice I-ORG Innovation I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Granted O No. O KYCX17_1067,http://www.jstd.gov.cn B-AWARD This O work O was O supported O by O National B-ORG Cancer I-ORG Institute I-ORG R15CA195499 O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG P20GM109024 O and O Sanford B-ORG Health-NDSU I-ORG Seed I-ORG Grant I-ORG FAR0026507 O The O funding O bodies O have O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O We O gratefully O acknowledge O the O support O from O the O Universidad B-ORG del I-ORG Bío-Bío I-ORG through O Project B-AWARD GI I-AWARD 152322/EF O Fondecyt-CONICYT B-ORG through O Project B-AWARD 1090781 I-AWARD and O Center B-ORG CRHIAM-FONDAP-CONICYT I-ORG through O Project B-AWARD 15130015 I-AWARD This O work O was O supported O by O the O Australian B-ORG Research I-ORG Council I-ORG DE150100652 O the O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG NHMRC O of O Australia O GNT1156567 O National B-ORG Institutes I-ORG of I-ORG Health I-ORG Rebuilding I-ORG a I-ORG Kidney I-ORG consortium I-ORG DK107344 O and O seed O funding O from O the O Murdoch O Children’s O Research O Institute O and O the O University O of O Melbourne O A.N.C O was O supported O by O a O Discovery O Early O Career O Researcher O Award O from O the O Australian O Research O Council O M.H.L O is O a O Senior O Principal O Research O Fellow O of O the O NHMRC O GNT1136085 O A.O O is O a O Career O Development O Fellow O of O the O NHMRC O L.Z O is O supported O by O an O Australian O Government O Research O Training O Program O RTP O Scholarship O MCRI O is O supported O by O the O Victorian O Government’s O Operational O Infrastructure O Support O Program O These O funding O bodies O had O no O role O in O any O aspect O of O the O study O design O execution O or O writing O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0201000;2017YFD0200803 O national B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41977095 O 31901479 B-AWARD 41771284 O Heilongjiang B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O ZD2017008 O Beijing B-ORG Academy I-ORG of I-ORG Agricultural I-ORG and I-ORG Forestry I-ORG Sciences I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Capacity I-ORG Building I-ORG Project(KJCX20190408 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Our O work O was O supported O by O grants O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81573747 B-AWARD Hong B-ORG Kong I-ORG Scholars I-ORG Program I-ORG No. O XJ2015033 B-AWARD Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG Western I-ORG Medicine I-ORG Guide I-ORG project I-ORG No. O 17411966500 B-AWARD and O Shanghai B-ORG Jiao I-ORG Tong I-ORG University I-ORG School I-ORG of I-ORG Medicine I-ORG doctoral I-ORG innovation I-ORG fund I-ORG No. O BXJ201737 B-AWARD This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81171880 O 81330027 B-AWARD 81525007 B-AWARD and O 31400919 B-AWARD the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2011CB51001 O 2012CB517900 B-AWARD and O the O excellent O youth O science O research O program O of O the O Education B-ORG Department I-ORG of I-ORG Hunan I-ORG Province I-ORG 14B183 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 21405069 B-AWARD Excellent O Talents O programme O of O Liaoning O Provincial O Universities O Department O of I-ORG Education I-ORG of I-ORG Liaoning I-ORG Province O LJQ2015068 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province I-ORG 201602339 O This O research O was O funded O by O NSFC B-ORG under O grant O numbers O 62275047 B-AWARD and O 61875241 B-AWARD MOST B-ORG under O Grant O Number O 2017YFA0205800 B-AWARD the O fellowship O of O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2022M710672 B-AWARD and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O BK20220816 B-AWARD This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG grant O number O 2018A0303130252 B-AWARD 2016B030309002 B-AWARD the O Major B-ORG scientific I-ORG research I-ORG projects I-ORG in I-ORG Colleges I-ORG and I-ORG universities I-ORG of I-ORG Guangdong I-ORG grant O number O 2017KTSCX081 B-AWARD the O Special B-ORG Supporting I-ORG Project I-ORG for I-ORG Educational I-ORG Talents I-ORG in I-ORG Universities I-ORG grant O number O 4SG19057G B-AWARD the O Medical B-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG grant O number O A2018495 B-AWARD the O Administration B-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG of I-ORG Guangdong I-ORG Province I-ORG grant O number O 20182069 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Fund I-ORG of I-ORG Zhanjiang I-ORG grant O number O 2017A0601 B-AWARD 2019A01019 B-AWARD and O the O Fund B-ORG of I-ORG Southern I-ORG Marine I-ORG Science I-ORG and I-ORG Engineering I-ORG Guangdong I-ORG Laboratory O Zhanjiang O grant O number O ZJW-2019-07 B-AWARD This O research O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 11705122 B-AWARD The B-ORG Project I-ORG of I-ORG Sichuan I-ORG provincial I-ORG science I-ORG and I-ORG Technology I-ORG Department I-ORG Grant O No. O 2017JY0338 B-AWARD 2019YJ0477 I-AWARD 2018GZDZX0043 O The B-ORG artificial I-ORG intelligence I-ORG key I-ORG laboratory I-ORG of I-ORG Sichuan I-ORG province I-ORG Foundation I-ORG 2017RYY02 O Sichuan B-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Engineering I-ORG talent I-ORG introduction I-ORG project I-ORG 2017RCL53 O Enterprise B-ORG informatization I-ORG and I-ORG Internet I-ORG of I-ORG things I-ORG measurement I-ORG and I-ORG control I-ORG technology I-ORG key I-ORG laboratory I-ORG project I-ORG of I-ORG Sichuan I-ORG provincial I-ORG university I-ORG 2018WZY01 O The B-ORG Project I-ORG of I-ORG Sichuan I-ORG Provincial I-ORG Academician I-ORG Expert I-ORG workstation I-ORG of I-ORG Sichuan I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Engineering I-ORG 2018YSGZZ04 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 31601387 B-AWARD 31771757 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No. O KJQN201727 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grant O No. O BE2016380 B-AWARD This O work O was O supported O by O the O Grant B-ORG Agency I-ORG of I-ORG Charles I-ORG University I-ORG GAUK O grant O no. O 1313320 B-AWARD and O by O the O National B-ORG Institute I-ORG for I-ORG Cancer I-ORG Research I-ORG Programme O EXCELES O ID O Project O No. O LX22NPO5102)—funded B-AWARD by O the O European O Union—Next O Generation O EU. O This O work O was O also O funded O by O Operational O Programme O Research O Development O and O Education O within O the O projects O Center B-ORG for I-ORG Tumor I-ORG Ecology—Research I-ORG of I-ORG the I-ORG Cancer I-ORG Microenvironment I-ORG Supporting I-ORG Cancer I-ORG Growth I-ORG and I-ORG Spread I-ORG reg O No. O CZ.02.1.01/0.0/0.0/16_019/0000785 B-AWARD This O work O was O supported O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O 81870575 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG for I-ORG Young I-ORG Scholars I-ORG of I-ORG China I-ORG grant O 81700718 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG grant O 2017A030310044 O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG grant O 2016YFC0906101 O Operational B-ORG Grant I-ORG of I-ORG Guangdong I-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG grant O 2017B030314019 O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG grant O 2017A050503003 O and O Guangzhou B-ORG Municipal I-ORG Program I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG grant O 201704020167 O This O work O was O supported O by O the O Talent B-ORG Project I-ORG of I-ORG Hunan I-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG 2020RC3057 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32060128 O Zhilan B-ORG foundation I-ORG 2020040371B O and O Opening O Projects O of O “Graduate O Student” O of O Jishou B-ORG University I-ORG JGY2022100 O DNGC2212 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31602131 O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-46 O and O Da B-ORG Bei I-ORG Nong I-ORG Group I-ORG promoted I-ORG Project I-ORG for I-ORG Young I-ORG Scholar I-ORG of I-ORG HZAU I-ORG No. O 2017DBN014 B-AWARD This O work O was O supported O by O Research B-ORG Fund I-ORG for I-ORG institutions I-ORG of I-ORG higher I-ORG learning I-ORG of I-ORG Gansu I-ORG Province I-ORG No. O 2017B-81 B-AWARD The B-ORG Fundamental I-ORG Research I-ORG Fund I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG from I-ORG Northwest I-ORG Minzu I-ORG University I-ORG China I-ORG No. O 31920180023 B-AWARD Fund B-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81360490 B-AWARD This O work O was O supported O by O theEuropean O Community's I-ORG Seventh I-ORG Framework I-ORG Programme(FP7/2007–2013 O under O the O project O Collaborative O HIV O and O Anti-HIV O Drug O Resistance O Network O project O number O 223131 B-AWARD theMedical O Research I-ORG Council(to O G. O M.; O grant O nr O MR/K010565/1),the B-AWARD National I-ORG Institute I-ORG of I-ORG Health(to O S.R O grant O nr O DP1DA034989 B-AWARD and O theAIDS O Reference I-ORG Laboratory I-ORG of I-ORG Leuven(which O receives O support O from O the O Belgian O Ministry O of O Social O Affairs O through O the O Fonds O voor O Wetenschappelijk O Onderzoek–Flanders O to O K. O T. O grant O nr O PDO/11 B-AWARD and O G069214N B-AWARD This O work O was O supported O by O the O grants O from O Jiangsu B-ORG Provincial I-ORG Medical I-ORG Youth I-ORG Talent I-ORG No. O QNRC2016658 B-AWARD Jiangsu B-ORG Preventive I-ORG Medicine I-ORG Association I-ORG Project I-ORG No. O Y2018091 B-AWARD and O Jiangsu B-ORG Cancer I-ORG Hospital I-ORG Project I-ORG No. O ZQ201107 B-AWARD This O study O was O supported O by O the O High-Level B-ORG Talent I-ORG Support I-ORG Project I-ORG of I-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Plan I-ORG Natural I-ORG Science I-ORG Field I-ORG of I-ORG Hainan I-ORG Province I-ORG grant O number O 2019RC152 B-AWARD the O initial B-ORG fund I-ORG from I-ORG Hainan I-ORG University I-ORG for I-ORG R I-ORG I-ORG D I-ORG grant O number O KYQD(ZR)1870 B-AWARD the O Research B-ORG and I-ORG Development I-ORG Program I-ORG Projects I-ORG in I-ORG Key I-ORG Areas I-ORG of I-ORG Guangdong I-ORG Province I-ORG grant O number O 2020B0202010001 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 32060832 B-AWARD This O work O was O funded O by O Jilin B-ORG Province I-ORG Innovation I-ORG Capacity I-ORG Building I-ORG Funds I-ORG Project I-ORG 2019lC0050-9 O Jilin B-ORG Province I-ORG Key I-ORG Technology I-ORG R&D I-ORG Project I-ORG 20180101212NY O and O Changchun B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 18DY023 O This O work O was O primarily O supported O by O grants O Russian B-ORG Science I-ORG Foundation I-ORG 14-14-00400 O and O Russian B-ORG Foundation I-ORG of I-ORG Basic I-ORG Research I-ORG 15-04-06685 O 15-29-01003 B-AWARD 16-34-60060 B-AWARD 16-34-00687 B-AWARD CRDF O FSCX-15-61168-0 O Goszadanie B-ORG 1354-2014/51 O 6.734.2016 B-AWARD and O partially O supported O by O the O US B-ORG Civil I-ORG Research I-ORG and I-ORG Development I-ORG Foundation I-ORG awards O FSCX-15-61168-0 O and O OISE-15-61170-0 B-AWARD and O by O the O Council O on O grants O from O the O President B-ORG of I-ORG the I-ORG Russian I-ORG Federation I-ORG for O support O of O leading O scientific O schools O NSh-9249.2016.5 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Grant O no: O 2016YFC0905400 B-AWARD 2016YFC1302500 B-AWARD 2017YFC0907900 B-AWARD 2018YFC1315000 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O no: O 81871885 B-AWARD 81673265 B-AWARD Training B-ORG Programme I-ORG Foundation I-ORG for I-ORG the I-ORG Talents I-ORG in I-ORG Beijing I-ORG City I-ORG Grant O no: O 2017000021223TD05 B-AWARD Beijing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG Grant O no: O D171100002617001 B-AWARD Special B-ORG Foundation I-ORG for I-ORG Central I-ORG Committee I-ORG Health I-ORG Care I-ORG Grant O no: O W2017BJ39 B-AWARD and O PUMC B-ORG Youth I-ORG Fund I-ORG Grant O no: O 2017320013 B-AWARD This O work O is O supported O by O grants O of O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG to I-ORG the I-ORG Innovation I-ORG Research I-ORG Group I-ORG 81621092 O the O Outstanding B-ORG Young I-ORG Scholar I-ORG 81622009 O and O other O programs O 81870486 O 81500542 B-AWARD and O the O Capital B-ORG of I-ORG Clinical I-ORG Characteristics I-ORG and I-ORG Applied I-ORG Research I-ORG Fund I-ORG Z161100000516039 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41671280 O the O Non-profit O Industry O Research O Project O of O Chinese B-ORG Ministry I-ORG of I-ORG Water I-ORG Resources I-ORG 201501045 O Key O Projects O in O the O National B-ORG Science I-ORG I-ORG Technology I-ORG Pillar I-ORG Program I-ORG during I-ORG the I-ORG Twelfth I-ORG Five-year I-ORG Plan I-ORG Period I-ORG 2015BAC01B01 O and O Special-Funds O of O Scientific B-ORG Research I-ORG Programs I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Soil I-ORG Erosion I-ORG and I-ORG Dryland I-ORG Farming I-ORG on I-ORG the I-ORG Loess I-ORG Plateau I-ORG A314021403-C6 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the B-ORG Youth I-ORG Program I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31402060,http://www.nsfc.gov.cn O the B-ORG Earmarked I-ORG Fund I-ORG for I-ORG Modern I-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG nycytx-41-Z01,http://www.zgrj.org O and O the B-ORG Innovation I-ORG Program I-ORG of I-ORG Beijing I-ORG Academy I-ORG of I-ORG Agriculture I-ORG and I-ORG Forestry I-ORG Sciences I-ORG KJCX20170105,http://www.baafs.net.cn O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Wellcome B-ORG Trust I-ORG grant O number O 099770/Z/12/Z B-AWARD to O MJG O the O Medical B-ORG Research I-ORG Council I-ORG grant O number O MC_UP_1302/2 B-AWARD to O APM O and O the O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG Cambridge I-ORG Biomedical I-ORG Research I-ORG Centre I-ORG MC_UP_1302/4 O to O JMSW O The O funding O bodies O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O 62266010 B-AWARD and O in O part O by O the O Cultivation B-ORG Project I-ORG of I-ORG Guizhou I-ORG University I-ORG No. O 2019]57 B-AWARD and O Research B-ORG Project I-ORG of I-ORG Guizhou I-ORG University I-ORG for I-ORG Talent I-ORG Introduction I-ORG No. O 2019]31 B-AWARD National B-ORG natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81370494 B-AWARD International B-ORG Science I-ORG and I-ORG Technology I-ORG Cooperation I-ORG Project I-ORG of I-ORG Henan I-ORG Province I-ORG in I-ORG China I-ORG grant O number O 182102410018 B-AWARD Excellent B-ORG Foreign I-ORG Scientist I-ORG Studio I-ORG of I-ORG Henan I-ORG Province I-ORG in I-ORG China I-ORG grant O number O GZS2018001 B-AWARD Medical B-ORG service I-ORG capacity I-ORG improvement I-ORG project I-ORG of I-ORG Henan I-ORG Province I-ORG in I-ORG China I-ORG grant O number O Yu B-AWARD Wei I-AWARD Medicine I-AWARD 2017 I-AWARD No.66 O National O Natural O Science O Foundation O of O China O grant O number O 31471330 B-AWARD the B-ORG Foundation I-ORG of I-ORG Henan I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG grant O number O 172102410014 B-AWARD Henan B-ORG Provincial I-ORG Medical I-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Joint I-ORG Co-construction I-ORG Project I-ORG grant O number O 2018020224 B-AWARD The B-ORG key I-ORG scientific I-ORG research I-ORG project I-ORG of I-ORG the I-ORG Foundation I-ORG of I-ORG Henan I-ORG Educational I-ORG Committee I-ORG FHEC O 18A320011 O and O the O major O project O of O the O Foundation B-ORG of I-ORG Zhengzhou I-ORG Collaborative I-ORG Innovation I-ORG FZCI O 18XTZX12003 O This O research O was O co-funded O by O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research O grant O number O RFN138354 B-AWARD the O Ontario B-ORG HIV I-ORG Treatment I-ORG Network I-ORG OHTN O under O Grant O REF#1052 O and O Winston B-ORG Husbands I-ORG Leadership I-ORG Award I-ORG of I-ORG the I-ORG OHTN I-ORG EFP-1131-WHA O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Funds I-ORG grant O no. O 81271834 B-AWARD the B-ORG Key I-ORG Issues I-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG and I-ORG Family I-ORG grant O no. O 201640005 B-AWARD and O the O 13th B-ORG Five-Year I-ORG New I-ORG Drug I-ORG Platform I-ORG grant O no. O SQ2017ZX090970 B-AWARD to O LZ. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O present O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG nos O 81201947 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG China I-ORG ZR2009CM014 O and O the O Excellent B-ORG Young I-ORG Scientist I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG China I-ORG no. O 2006BSB14001 B-AWARD Qingdao B-ORG minsheng I-ORG science I-ORG and I-ORG technology I-ORG project I-ORG no.17-3-3-38-nsh O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2022YFD1200700 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 32172040 B-AWARD the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG of I-ORG MOF I-ORG and I-ORG MARA I-ORG Grant O No. O CARS-03 B-AWARD and O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG Grant O No. O CAAS-ZDRW202109 B-AWARD This O work O was O supported O by O the O Frontier B-ORG Science I-ORG Key I-ORG Project I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG QYZDJ-SSW-SMC024 O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDB11050000 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31110103903 O 31222013 I-AWARD and I-AWARD 31702018 O This O work O was O funded O by O the O Foundation O of O Pre-research B-ORG Project I-ORG of I-ORG National I-ORG Natural I-ORG Social I-ORG Science I-ORG Foundation I-ORG of I-ORG North I-ORG Sichuan I-ORG Medical I-ORG College I-ORG CBY19-YZ13 O Key B-ORG Project I-ORG of I-ORG Affiliated I-ORG Hospital I-ORG of I-ORG North I-ORG Sichuan I-ORG Medical I-ORG College I-ORG 2019ZD006 O Nanchong B-ORG City I-ORG School I-ORG Cooperative I-ORG Research I-ORG and I-ORG Innovation I-ORG Team I-ORG Construction I-ORG Project I-ORG 20SXCXTD0001 O Natural O Science O Foundation O of O Sichuan O Province O 2022NSFSC0775 O Open O project O of O Sichuan O Key O Laboratory O of O Medical O Imaging O MIKL202206 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O 81672334 B-AWARD 81573423 I-AWARD and I-AWARD 81770137 O Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG under O Grant O 15410710100 B-AWARD and I-AWARD 16ZR1406100 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG under O Grant O 20192BAB215033 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O authors O report O no O conflict O of O interest O concerning O the O materials O or O methods O used O in O this O study O or O the O findings O specified O in O this O paper O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grants O No.81271315 O National B-ORG Key I-ORG Research I-ORG Development I-ORG Program I-ORG Grants O No.2016YFC1300804,2016YFC1300800 O Specialized B-ORG Research I-ORG Fund I-ORG for I-ORG the I-ORG Doctoral I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG Grants O No.20124433110014 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 52161018 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Grant O No. O 20224BAB214041 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Jiangxi I-ORG Educational I-ORG Bureau I-ORG Grant O No. O GJJ212304 B-AWARD Grant O No. O GJJ212307 B-AWARD and O Grant O No. O GJJ2202213 B-AWARD and O the O Science B-ORG Technology I-ORG Project I-ORG of I-ORG Jiujiang I-ORG City I-ORG Grant O No. O 2015 B-AWARD No.64 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No O 30571513 B-AWARD Overseas B-ORG Expertise I-ORG Introduction I-ORG Project I-ORG for I-ORG Discipline I-ORG Innovation I-ORG B16010 O and O Heilongjiang B-ORG Touyan I-ORG Innovation I-ORG Team I-ORG Program I-ORG Tree O Genetics I-AWARD and I-AWARD Breeding I-AWARD Innovation I-AWARD Team O The O funding O bodies O played O no O role O in O the O design O of O the O study O collection O analysis O or O interpretation O of O data O or O writing O of O the O manuscript O This O work O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20210805 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32102635 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2022M722693 O This O study O was O supported O by O the O Central B-ORG Public I-ORG Interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG CAFYBB2016QA001 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31700586 O and O Hainan B-ORG university I-ORG research I-ORG funded I-ORG projects I-ORG KYQD(ZR)1701 O These O funding O agencies O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O study O was O supported O by O the B-ORG National I-ORG Natural I-ORG Youth I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81601252 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81771540 B-AWARD the B-ORG Jiangsu I-ORG Medical I-ORG Innovation I-ORG team I-ORG grant O number O CXTDA2017004 B-AWARD and O a O project O Funded O by O the O priority O Academic O Program O Development O of O Jiangsu O higher O Education O Institutions O The O research O was O funded O by O the O Croatian B-ORG Science I-ORG Foundation I-ORG No. O IP-2018-01-4729 B-AWARD The O Article O Processing O Charge O was O funded O by O the O Split-Dalmatia B-ORG County I-ORG grant O No. O 201900157031 B-AWARD and O the O City B-ORG of I-ORG Split I-ORG Excellence O Grant O No. O OS520014 B-AWARD This O work O is O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG DMS-1264153 O DBI-1356562 B-AWARD DBI-1661443 B-AWARD and O DEB-1354146 B-AWARD National B-ORG Institutes I-ORG of I-ORG Health I-ORG R01 O HG006139 O R01 B-AWARD AI107034 O and O U19 B-AWARD AI135995 O Wellcome B-ORG Trust I-ORG 206298/Z/17/Z O The O Bill B-ORG I-ORG Melinda I-ORG Gates I-ORG Foundation I-ORG OPP1175094 O and O European B-ORG Research I-ORG Council I-ORG 725422-ReservoirDOCS O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O Grant O 31822043 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province O China O BK20170026 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG China I-ORG KJYQ201902 O to O G.H O This O work O was O supported O by O the B-ORG National I-ORG key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFB0703800 O and O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NNSFC O 21273172 O This O work O was O also O supported O by O the B-ORG 111 I-ORG Project I-ORG B08040 O and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 3102015BJ(II)JGZ005 O 3102015BJ023 O in O China O The O work O for O this O review O was O supported O by O an O American B-ORG College I-ORG of I-ORG Clinical I-ORG Pharmacy I-ORG Foundation I-ORG New B-AWARD Investigator I-AWARD Award I-AWARD LFB O National B-ORG Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute I-ORG grants O R01HL135008 B-AWARD and O R01HL143224 B-AWARD AMS O and O a O Watkins B-AWARD Discovery I-AWARD Award I-AWARD from O the O Brigham B-ORG and I-ORG Women’s I-ORG Heart I-ORG and I-ORG Vascular I-ORG Center I-ORG AMS O This O study O is O supported O by O the O Shenzhen B-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG SZBC2018011 O Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Committee I-ORG JCYJ20160429102107498 O and O Shenzhen B-ORG Medical I-ORG Sanming I-ORG Project I-ORG SZSM201612045 O The O funders O were O not O involved O in O the O study O design O data O collection O analysis O interpretation O or O manuscript O preparation O This O work O was O supported O by O the O Ministry O of O Science O O ICT O MSIT O and O the O Ministry O of O Trade O Industry O and O Energy O MOTIE O of O Korea O through O the O National B-ORG Research I-ORG Foundation I-ORG 2019R1A2B5B03069358 O 2016R1A5A1009926 B-AWARD and O 2018R1A2A1A05019733 B-AWARD the O Bio O O Medical O Technology O Development O Program O 2018M3A9F1021649 O the O Nano O Material O Technology O Development O Program O 2015M3A7B4050308 O and O 2016M3A7B4910635 O and O Industry O Technology O Development O Program O 10080540 O Also O the O authors O thank O financial O support O by O the O Institute B-ORG for I-ORG Basic I-ORG Science I-ORG IBS-R026-D1 O and O the O Research O Program O 2018-22-0194 O funded O by O Yonsei B-ORG University I-ORG This O work O was O funded O by O the O Intramural O Research O Program O of O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG to O MPM)(Project O Number O 1ZIAHD008893-07 B-AWARD and O by O the O Spanish B-ORG Ministry I-ORG of I-ORG Economy I-ORG and I-ORG Competitiveness I-ORG Grant I-ORG to O AH)(BFU2014-59759-R O and O the O Severo B-ORG Ochoa I-ORG Excellence I-ORG Accreditation I-ORG to O AH)(SEV-2016-0644 O This O study O made O use O of O the O Diamond O Light O Source O beamline O I04 O Oxfordshire O UK) O and O ALBA O synchrotron O beamline O BL13-XALOC O funded O in O part O by O the O Horizon O 2020 O programme O of O the O European O Union O iNEXT O H2020 O Grant O O 653706 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Outstanding I-ORG Youth I-ORG Science I-ORG Fund I-ORG Project I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O the O National O Natural O Science O Foundation O of O China)81460492 O Basic B-ORG Research I-ORG Grant I-ORG of I-ORG Yunnan I-ORG Province I-ORG grant O 2017FE468-189 B-AWARD Teaching B-ORG Reform I-ORG and I-ORG Teaching I-ORG Research I-ORG of I-ORG Kunming I-ORG Medical I-ORG University I-ORG grant O 2019-JY-Y-005 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O a O Korea B-ORG Science I-ORG and I-ORG Engineering I-ORG Foundation I-ORG KOSEF O grant O NRF-2015M3A9E7029177 O and O the O Priority B-ORG Research I-ORG Centers I-ORG Program I-ORG NRF-2014R1A6A1030318 O through O the O National O Research O Foundation O of O Korea O JGK O was O supported O by O a O grant O of O the O Korea B-ORG Health I-ORG Technology I-ORG R&D I-ORG Project I-ORG through O the O Korea O Health O Industry O Development O Institute O KHIDI O funded O by O the O Ministry O of O Health O O Welfare O Republic O of O Korea O grant O number O HI17C1600 B-AWARD This O work O was O supported O by O grants O from O Jinshan B-ORG Hospital I-ORG Fudan I-ORG University I-ORG JYQN-LC-202010 O to O Weifang O Ren O “Qi B-ORG Hang” I-ORG Project I-ORG of I-ORG Jinshan I-ORG Hospital I-ORG Fudan I-ORG University I-ORG 2018-JSYYQH-05 O and O Fourth B-ORG Training I-ORG Program I-ORG for I-ORG the I-ORG Outstanding I-ORG Young I-ORG Talents I-ORG Jinshan I-ORG Health I-ORG Commission I-ORG JSYQ201904 O to O Xiaoqun O Lv, O Key B-ORG Construction I-ORG Project I-ORG on I-ORG Clinical I-ORG Pharmacy I-ORG of I-ORG Shanghai I-ORG 2019-1229 O This O work O was O supported O by O theWellcome O TrustgrantsWT093378MAandWT099197MAto O T.F O and O W.C O and O theUK O Research I-ORG Councils’ I-ORG Basic I-ORG Technology I-ORG Initiative I-ORG “Glycoarrays”(GRS/79268 O andEPSRC O Translational I-ORG Grant(EP/G037604/1 O to O T.F.;Natural O Science I-ORG Foundation I-ORG of I-ORG China(31201384 O to O H.Z O and O theFundação O para I-ORG a I-ORG Ciência I-ORG e I-ORG Tecnologia I-ORG FCT I-ORG FCT I-ORG InvestigatorandPTDC/QUI-QUI/112537/2009to O A.S.P.,RECI/BBB-BEP/0124/2012andUID/Multi/04378/2013grants O H.Z O was O supported O byChina O Scholarship I-ORG Council(CSC:2008679005 O Funding O to O pay O the O Open O Access O publication O charges O for O this O article O was O provided O by O Wellcome O Trust O Grant O WT099197MA O This O study O was O funded O by O the O Ministry B-ORG of I-ORG Economy I-ORG and I-ORG Competitiveness-Carlos I-ORG III I-ORG Health I-ORG Institute I-ORG and O FEDER B-ORG funds O FIS O PI12/02400 I-AWARD and O FIS B-AWARD PI12/00761 O Additional O funding O was O obtained O from O the O Research B-ORG Network I-ORG on I-ORG Preventative I-ORG Activities I-ORG and I-ORG Health I-ORG Promotion I-ORG Ref O O RD12/0005/0009 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81470028 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Action I-ORG Plan I-ORG of I-ORG Shanghai I-ORG 2016 I-ORG No. O 16140900900 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 1508219071 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Zhejiang B-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG Administration I-ORG Bureau I-ORG Project O NO. O 2011ZA093 B-AWARD Public B-ORG Welfare I-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2014C33277 O 2013C33209 O 2017C33062 O Natural O Science O Foundation O of O Zhejiang O Province O of O China O LY17H160001 O and O Science B-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG of I-ORG Hangzhou I-ORG City I-ORG 20130633B29 O 20140633B40 I-AWARD and I-AWARD 20160533B74 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O No. O 21676120 O the O 111 B-ORG Project I-ORG No. O 111-2-06 B-AWARD the O High-End O Foreign O Experts O Recruitment O Program O No. O G20190010083 O the O Program O for O Advanced O Talents O within O Six O Industries O of O Jiangsu O Province O No. O 2015-NY-007 O the O National O Program O for O Support O of O Top-Notch O Young O Professionals O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O JUSRP51504 B-AWARD the O Project O Funded O by O the O Priority O Academic O Program O Development O of O Jiangsu O Higher O Education O Institutions O Top-Notch O Academic O Programs O Project O of O Jiangsu O Higher O Education O Institutions O the O Jiangsu O Province O “Collaborative O Innovation O Center O for O Advanced O Industrial O Fermentation” O Industry O Development O Program O the O Postgraduate O Research O O Practice O Innovation O Program O of O Jiangsu O Province O No. O KYCX19_1833 O the O Program O for O the O Key O Laboratory O of O Enzymes O of O Suqian O No. O M201803 O and O the O National O First-Class O Discipline O Program O of O Light O Industry O Technology O and O Engineering O No. O LITE2018-09 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG http://www.nsfc.gov.cn O 31472270 O to O XSJ O the O Research B-ORG Award I-ORG Fund I-ORG for I-ORG outstanding I-ORG young I-ORG scientists I-ORG of I-ORG Shandong I-ORG Province I-ORG http://jihlx.sdstc.gov.cn/STDPMS/BS/Default.aspx O 2014BSB01303 O to O YZ O and O the B-ORG earmarked I-ORG fund I-ORG for I-ORG Modern I-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG in I-ORG Shandong I-ORG Province I-ORG SDAIT-13 O and O SDAIT-15-011 O to O XSJ O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O study O has O been O supported O by O the O project O of O the O National B-ORG Agency I-ORG of I-ORG Academic I-ORG Exchange I-ORG nr O PPN/BCN/2019/1/00066/U/00001 B-AWARD S.J O and O K.K O and O by O the O International B-ORG Cooperation I-ORG Project I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG G2021026025L O the O Open B-ORG Project I-ORG of I-ORG Henan I-ORG Clinical I-ORG Medical I-ORG Research I-ORG Center I-ORG of I-ORG Childhood I-ORG Diseases I-ORG YJZX202205 O and O the O Special B-ORG Key I-ORG Project I-ORG of I-ORG Henan I-ORG Province I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG Scientific I-ORG Research I-ORG 20-21ZY1072 O C.G O F.J O D.M O and O X.W O This O study O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFC0909700 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31601073 B-AWARD and O the O Shenzhen B-ORG Municipal I-ORG Government I-ORG of I-ORG China I-ORG No. O JSGG20160229172752028 B-AWARD and O No. O JCYJ20160229172757249 B-AWARD This O work O was O supported O by O Young O Talents O Training O Program O of O Shandong B-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG CXGC2018E04 O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0300700 O 2017YFD0201700 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31400019 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG BS2015SW020 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the O Czech B-ORG Science I-ORG Foundation I-ORG 17-15480S O Institute B-ORG of I-ORG Vertebrate I-ORG Biology I-ORG 900620 O and O institutional B-ORG support I-ORG RVO O 68081766 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O F O Moreira O was O funded O by O the O REN B-ORG Biodiversity I-ORG Chair I-ORG and I-ORG FCT I-ORG IF/01053/2015 O RLC O and O RMC O were O supported O by O post-doctoral O fellowships O from O FCT—Portuguese O Science I-ORG Foundation I-ORG SFRH/BPD/109685/2015 O and O SFRH/BPD/85040/2012 B-AWARD respectively O CCMAR O team O was O supported O by O the O Portuguese B-ORG Foundation I-ORG for I-ORG Science I-ORG I-ORG Technology I-ORG FCT I-ORG through O the O strategic O project O UID/Multi/04326/2013 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O project O is O funded O by O the B-ORG Important I-ORG Weak I-ORG Discipline I-ORG of I-ORG Shanghai I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG Pediatrics I-ORG no. O 2016ZB0104 B-AWARD the O Shanghai I-ORG Pudong I-ORG New I-ORG Area I-ORG Municipal I-ORG Planning I-ORG Commission I-ORG of I-ORG Science I-ORG and I-ORG Research I-ORG Fund I-ORG no. O PW2017E-1 B-AWARD “Action O plan O of O scientific O and O technological O innovation” O medical O device O field O project O of O the B-ORG Shanghai I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG 19441909000 O and O the B-ORG Key I-ORG Project I-ORG of I-ORG China I-ORG Hospital I-ORG Development I-ORG Institute I-ORG of I-ORG Shanghai I-ORG Jiaotong I-ORG University I-ORG CHDI-2017-A-06 O These O funding O bodies O do O not O play O any O role O in O designing O the O study O collecting O analysing O and O interpreting O the O data O or O writing O the O manuscript O This O manuscript O was O supported O by O Beijing B-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospitals I-ORG Clinical I-ORG Medicine I-ORG Development I-ORG of I-ORG Special I-ORG Funding I-ORG Support I-ORG ZYLX201304 O Tongzhou B-ORG District I-ORG Science I-ORG and I-ORG Technology I-ORG Committee I-ORG No. O KJ2017CX053 B-AWARD and O Beijing B-ORG Bio-Bank I-ORG of I-ORG Clinical I-ORG Resources-Tuberculosis I-ORG BBCR-Tuberculosis I-ORG D131100005313012 O for O their O financial O support O C.R.H O was O supported O by O an O Engineering B-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG EPSRC O doctoral O training O award O EP/J500367/1 O G.C O was O supported O by O a O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG Industrial O CASE O studentship O BB/L015587/1 O J.E.F.G O acknowledges O the O support O of O the O Australian B-ORG Research I-ORG Council I-ORG ARC O Discovery O Early O Career O Researcher O Award O DE130100031 O and O R.J.D O the O support O of O the O EPSRC O grant O no. O EP/M00015X/1 B-AWARD C.R.H O is O grateful O to O Universitas O 21 O and O the O Institute O of O Mathematics O and O its O Applications O for O supporting O travel O to O visit O J.E.F.G O and O R.J.C O This O research O was O funded O by O the O Bill B-ORG and I-ORG Melinda I-ORG Gates I-ORG Foundation I-ORG OPP1035218 O OPP1174957 B-AWARD This O research O was O supported O by O an O Australian B-ORG Research I-ORG Council I-ORG Discovery O and O Linkage O Projects O funding O DP160101429 O LP120100485 B-AWARD and O equipment O support O LE120100170 O LE140100119 B-AWARD This O research O was O funded O by O the O National B-ORG Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases O National O Institutes O of O Health O Department O of O Health O and O Human O Services O under O Federal O Contract O number O HHSH27220120025C B-AWARD HHSN272200700057C B-AWARD and O HHSN272201700059C B-AWARD This O study O was O financially O supported O by O the B-ORG National I-ORG Youth I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81600536 O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG of I-ORG China I-ORG No. O 2018JJ3833 O and O China’s B-ORG Xiangya I-ORG medical I-ORG big I-ORG data I-ORG project I-ORG No.33020125032 O which O is O sponsored O by O Central O South O University O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O present O review O was O supported O by O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O nos O 81372872 B-AWARD 81402215 B-AWARD and O 81320108022 B-AWARD Nature B-ORG Science I-ORG Foundation I-ORG of I-ORG Tianjin I-ORG grant O no. O 16JCYBJC24100 B-AWARD and O the O program O for O Innovative B-ORG University I-ORG Research I-ORG Teams I-ORG in I-ORG China I-ORG grant O no. O IRT_14R40 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81602913 O 81670155 B-AWARD have O supported O design O and O data O collection O of O the O study O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20150085 O have O supported O data O collection O Nanjing B-ORG Medical I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Project I-ORG YKK15140 O have O supported O data O analysis O Nanjing B-ORG Medical I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Foundation I-ORG QRX17164 O and O Nanjing B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Foundation I-ORG 201503043 O have O supported O interpretation O of O data O and O writing O of O the O manuscript O Technology B-ORG Development I-ORG Foundation I-ORG of I-ORG Nanjing I-ORG Medical I-ORG University I-ORG 2014NJMUZD079 O have O also O supported O writing O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41877029 O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0800206 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2662017JC008 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61664008 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 2017JM6102 O the O National O College O Training O Program O of O Innovation O and O Entrepreneurship O for O Undergraduates O 201910719007 O the O Scientific B-ORG and I-ORG Technological I-ORG Innovation I-ORG Team I-ORG 2017CXTD-01 O and O the O project O of O production O learning O and O research O cooperation O 2017cxy05 O This O work O was O sponsored O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81373161 B-AWARD Medical B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG grant O number O 2012ZDA017 B-AWARD Medical B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Department I-ORG of I-ORG Health I-ORG of I-ORG Zhejiang I-ORG Provincial I-ORG Government I-ORG grant O number O 2012KYA081 B-AWARD Zhejiang B-ORG Provincial I-ORG Outstanding I-ORG Young I-ORG Talent I-ORG Program I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG grant O number O 2012ZQ016 B-AWARD and O the O Educational B-ORG Commission I-ORG of I-ORG Zhejiang I-ORG Province I-ORG of I-ORG China I-ORG grant O number O Y201017002 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 91632103 B-AWARD Program B-ORG of I-ORG Shanghai I-ORG Subject I-ORG Chief I-ORG Scientist I-ORG 17XD1401700 B-AWARD Shanghai B-ORG Education I-ORG Commission I-ORG Research I-ORG and I-ORG Innovation I-ORG Program I-ORG 2019-01-07-00-02-E00037 B-AWARD “111” O Program O of O Higher O Education O Discipline O Innovation O and O “Eastern O Scholar” O Shanghai O Municipal O Education O Commission O This O work O was O supported O by O grants O from O Key B-ORG projects I-ORG of I-ORG Wenzhou I-ORG science I-ORG and I-ORG technology I-ORG bureau I-ORG ZY2019016 O Provinces B-ORG and I-ORG Ministries I-ORG Co-Contribution I-ORG of I-ORG Zhejiang I-ORG China I-ORG WKJ-ZJ-2035 O National B-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG of I-ORG China I-ORG 81800567 O and O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG LY17H160057 O Grants O This O work O was O supported O by O an O award O from O the O American B-ORG Heart I-ORG Association O 12PRE11380003 O and O the O National O Institutes O of O Health O National B-ORG Institute I-ORG of I-ORG Neurological I-ORG Disorders I-ORG and I-ORG Stroke O 1R15NS084130-01 O Contents O of O this O publication O were O also O developed O under O a O grant O from O the O National B-ORG Institute I-ORG on I-ORG Disability I-ORG Independent I-ORG Living I-ORG and I-ORG Rehabilitation I-ORG Research I-ORG NIDILRR O grant O number O 90RE5006-01-00 B-AWARD NIDILRR O is O a O Center O within O the O Administration O for O Community O Living O ACL O Department O of O Health O and O Human O Services O HHS O The O contents O of O this O publication O do O not O necessarily O represent O the O policy O of O NIDILRR O ACL O HHS O and O you O should O not O assume O endorsement O by O the O Federal O Government O This O research O was O supported O by O the O Program B-ORG for I-ORG Changjiang I-ORG Scholars I-ORG and I-ORG Innovative I-ORG Research I-ORG Team I-ORG in I-ORG University I-ORG IRT_17R50 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31502000 O the O 111 B-ORG project I-ORG B12002 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG lzujbky-2016-8 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Guangdong B-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Projects I-ORG 2016A050502032 O Guangzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Projects I-ORG 201504281708257 O Guangzhou O Traditional O Chinese O Medicine O and O Integrated O Chinese O and O Western O Medicine O Science O and O Technology O Project O 20192A011019 O and O Guangzhou B-ORG Medical I-ORG University I-ORG Research I-ORG Projects I-ORG 2016C28 O This O research O was O funded O by O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG Project O Grant O APP1140874 B-AWARD M.J.S O M.C O J.R.L O Australian B-ORG Research I-ORG Council I-ORG Discovery O Grant O DP130101984 B-AWARD M.J.S O Monash B-AWARD Institute I-AWARD of I-AWARD Pharmaceutical I-AWARD Sciences I-AWARD Large I-AWARD Grant I-AWARD Support I-AWARD Scheme I-AWARD M.C O and O Monash B-ORG University I-ORG Joint B-AWARD Medicine-Pharmacy I-AWARD grant I-AWARD JMP16-18 I-AWARD M.J.S O and O M.C O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61573274 O SD; O Postdoctoral B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 2015M582661 O YY; O Natural B-ORG Science I-ORG Basic I-ORG Research I-ORG Plan I-ORG in I-ORG Shaanxi I-ORG Province I-ORG of I-ORG China I-ORG 2015JQ6232 O YY; O and O National O Natural O Science O Foundation O of O China O 61379104 O This O work O was O supported O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O number O 31660408 B-AWARD 31260339 O Scientific B-ORG and I-ORG Technological I-ORG Achievement I-ORG Transformation I-ORG Project I-ORG of I-ORG Bingtuan I-ORG Grant O number O 2016AC017 B-AWARD and O Distinguished B-ORG Youth I-ORG innovation I-ORG foundation I-ORG of I-ORG Bingtuan I-ORG Grant O number O 2014CD003 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O is O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG ID:2019A1515010754 O Major B-ORG Diseases I-ORG Prevention I-ORG and I-ORG Treatment I-ORG Plan I-ORG No.2018ZX-01S-002 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81802217 B-AWARD This O research O was O funded O by O INSTITUTO B-ORG POLITECNICO I-ORG NACIONAL I-ORG SIP-20221367 O and O CONACYT B-ORG Proyecto O 316093 B-AWARD A.M.B.O O thanks O CONACyT O and O BEIFI-IPN O program O A.G.C O was O supported O by O grant O PID2019-107657RB-C22 B-AWARD funded O by O the O Agencia B-ORG Estatal I-ORG de I-ORG Investigación—Ministerio I-ORG de I-ORG Ciencia I-ORG e I-ORG Innovación I-ORG Spain I-ORG It O is O supported O by O the B-ORG Public I-ORG Welfare I-ORG Research I-ORG Project I-ORG of I-ORG National I-ORG Health I-ORG Planning I-ORG Commission I-ORG No. O 201502028 B-AWARD the B-ORG Excellent I-ORG Discipline I-ORG Leader I-ORG Training I-ORG Program I-ORG of I-ORG Shanghai I-ORG Health I-ORG System I-ORG No. O 2017BR037 B-AWARD and O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81772091 B-AWARD This O research O was O funded O by O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 11618323 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 91544215 O 41373116 O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2018YFC0213602 O and O Guangdong O Provincial O Science O and O Technology O Planning O Project O of O China O No.2017B050504002 O This O research O was O funded O by O West B-ORG Light I-ORG Foundation I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG CAS O XAB2017B20 O China B-ORG Scholarship I-ORG Council I-ORG CSC O 201804910323 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 61505246 O National B-ORG Science I-ORG Foundation I-ORG NSF O 1918260 O This O study O was O supported O by O the B-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG Leaders I-ORG in I-ORG Central I-ORG Plains I-ORG Grant O No. O 194200510017 B-AWARD Provincial B-ORG Ministry I-ORG Co-Construction I-ORG Project I-ORG from I-ORG the I-ORG Medical I-ORG Scientific I-ORG and I-ORG Technological I-ORG Research I-ORG Program I-ORG of I-ORG Henan I-ORG Province I-ORG Grant O No. O SBGJ2018020 B-AWARD the O “51282” O Project O Leaders O of O Scientific O and O Technological O Innovative O Talents O from O Health O and O Family O Planning O Commission O in O Henan O Province O 2016-32 O and O Science B-ORG and I-ORG Technology I-ORG People-Benefit I-ORG Project I-ORG of I-ORG Zheng I-ORG Zhou I-ORG 2019KJHM0001 O This O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O numbers O 82002457 B-AWARD and O 82102991 B-AWARD the O Fujian B-ORG Provincial I-ORG Health I-ORG Technology I-ORG Project I-ORG Grant O number O 2019-ZQNB-1 B-AWARD 2020GGA010 B-AWARD and O 2021GGA042 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG Grant O number O 2020J011106 B-AWARD and O the O Joint B-ORG Funds I-ORG for I-ORG the I-ORG Innovation I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG in I-ORG Fujian I-ORG Province I-ORG Grant O number O 2020Y9023 B-AWARD This O research O was O supported O by O the O Humanities B-ORG and I-ORG Social I-ORG Sciences I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG No. O 20YJC790061 I-AWARD and O No. B-AWARD 22YJC790158 O Shandong B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O ZR2020QD010 O Social B-ORG Science I-ORG Project I-ORG of I-ORG Shandong I-ORG Province I-ORG No. O 21DGLJ22 O Shandong B-ORG Provincial I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG No. O SFC2019001 O and O Zaozhuang B-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG No. O 2021GH22 O The O present O study O was O supported O by O research O Grants O from O the O Polish B-ORG National I-ORG Science I-ORG Centre I-ORG Grant O Numbers O DEC-2011/01/B/ST7/06801 B-AWARD the O Slovak B-ORG Research I-ORG and I-ORG Development I-ORG Agency I-ORG APVV-14-0875 O and O the O VEGA B-ORG Grant I-ORG Agency I-ORG in I-ORG Slovakia I-ORG 2/0071/16 O This O work O was O supported O by O the B-ORG Key I-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 81430040 B-AWARD to O X.Y O National O Natural O Science O Foundation O of O China O no. O 81571738 B-AWARD 81871403 B-AWARD to O J.S O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG no. O 2016YFA0100900 B-AWARD to O J.S O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Province I-ORG no. O 2019C03014 B-AWARD to O J.S O Medical B-ORG and I-ORG Health I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Province I-ORG no. O 2019338991 B-AWARD to O F.Z O The O funders O had O no O role O in O study O design O data O collection O analysis O and O interpretation O preparation O of O the O manuscript O and O decision O to O submit O the O manuscript O for O publication O This O research O was O funded O by O the O Trauma O Microsurgery O Clinical O Medical O Research O Center O of O Hubei O Province O and O the B-ORG Health I-ORG Commission I-ORG of I-ORG Hubei I-ORG Province I-ORG Medical I-ORG Leading I-ORG Talent I-ORG Project O grant O number O LJ20200405 B-AWARD the O Hubei B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Project O grant O number O 2022CFB699 B-AWARD and O the B-ORG Medical I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Hubei I-ORG Provincial I-ORG Health I-ORG Commission O grant O number O WJ2021F111 B-AWARD This O research O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG NO. O 2018YFD0200500 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO. O 31672069 B-AWARD and O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG NO. O 2022M710917 B-AWARD This O research O was O funded O by O the O Key B-ORG Project I-ORG for I-ORG Center I-ORG of I-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG and I-ORG New I-ORG Economy I-ORG Institute I-ORG of I-ORG Chengdu–Chongqing I-ORG Economic I-ORG Zone I-ORG No. O CYCX2022ZD02 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2022MD713678 B-AWARD the O Major B-ORG Program I-ORG of I-ORG Philosophy I-ORG and I-ORG Social I-ORG Sciences I-ORG Planning I-ORG in I-ORG Sichuan I-ORG Province I-ORG No:SC22ZDYC45 O the O Project B-ORG of I-ORG Sichuan I-ORG Research I-ORG Center I-ORG for I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG Health I-ORG Industry I-ORG Development I-ORG and I-ORG Rural I-ORG Revitalization I-ORG No: O DJKYB202207 B-AWARD the O Project B-ORG of I-ORG Research I-ORG Center I-ORG of I-ORG Chengdu I-ORG into I-ORG the I-ORG New I-ORG Pattern I-ORG of I-ORG Dual I-ORG Circulation I-ORG Development I-ORG and I-ORG Research I-ORG Center I-ORG of I-ORG Sichuan I-ORG into I-ORG the I-ORG New I-ORG Pattern I-ORG of I-ORG Dual I-ORG Circulation I-ORG Development I-ORG No: O CDNUSXH2021YB-04 B-AWARD Development O of O PCR O to O detect O virus,G O lambliawas O supported O by O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG Grant O number O 2008ZX10004-011 B-AWARD Development O of O PCR O to O findCryptosporidiumspp O was O supported O by O National O Science O and O Technology O Major O Project O 2012ZX10004-220 O TheB O hominisidentified O was O supported O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O number O 81473022 B-AWARD The O field O epidemiological O investigation O was O supported O by O Chinese B-ORG Special I-ORG Program I-ORG for I-ORG Scientific I-ORG Research I-ORG of I-ORG Public I-ORG Health I-ORG No. O 201502021 B-AWARD The O bacterial O pathogens O identified O was O supported O by O The B-ORG Fourth I-ORG Round I-ORG Three I-ORG Year I-ORG Action I-ORG Plan I-ORG Public I-ORG Health I-ORG of I-ORG Shanghai I-ORG city I-ORG GWIV-29 O The O data O analysis O was O supported O from O the O fund O of O the O postdoctoral B-ORG programme I-ORG of I-ORG the I-ORG Fundação I-ORG para I-ORG a I-ORG Ciência I-ORG ea I-ORG Tecnologia I-ORG the I-ORG Fundação I-ORG para I-ORG a I-ORG Ciência I-ORG ea I-ORG Tecnologia I-ORG Portugal I-ORG SFRH/BPD/96637/2013 O This O study O was O supported O by O grants O from O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guang I-ORG Dong I-ORG Province I-ORG No. O 2017A030312003 B-AWARD Health B-ORG I-ORG Medical I-ORG Collaborative I-ORG Innovation I-ORG Project I-ORG of I-ORG Guangzhou I-ORG City I-ORG China I-ORG 201803040003 O Innovation B-ORG Team I-ORG Development I-ORG Plan I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG No. O IRT_17R110 B-AWARD and O Overseas B-ORG Expertise I-ORG Introduction I-ORG Project I-ORG for I-ORG Discipline I-ORG Innovation I-ORG 111 O Project O B14035 B-AWARD Funding O was O provided O by O the O National B-ORG Institute I-ORG of I-ORG Environmental I-ORG Health I-ORG Sciences I-ORG T32 O ES007060-31A1 O Husson B-ORG University I-ORG School I-ORG of I-ORG Pharmacy I-ORG to O BJP O 2013-01 O and O the O Fahs-Beck B-ORG Fund I-ORG for I-ORG Research I-ORG and I-ORG Experimentation I-ORG to O BJP O 2017-01 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O project O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31502074 B-AWARD and O 31760732 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Fund I-ORG of I-ORG Guizhou I-ORG Province I-ORG No. O QKH-2015-2054 B-AWARD the O Agricultural B-ORG Research I-ORG Project I-ORG of I-ORG Guizhou I-ORG Province I-ORG No. O QKHZC-2016-2588 B-AWARD the O Chinese B-ORG Special I-ORG Fund I-ORG for I-ORG Agro-scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG No. O 201303033 B-AWARD and O the O Scientific B-ORG Research I-ORG Project I-ORG of I-ORG Guizhou I-ORG University I-ORG Talents I-ORG Fund I-ORG No. O GDRJHZ-2014-10 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81860670 B-AWARD the O Guangxi B-ORG Innovation I-ORG Team I-ORG Project I-ORG of I-ORG Tubers I-ORG of I-ORG Modern I-ORG Agricultural I-ORG Industrial I-ORG Technology I-ORG System I-ORG of I-ORG China I-ORG nycytxgxcxtd-11-01 O and O the O Guangxi B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 2018GXNSFDA281029 B-AWARD This O research O was O supported O by O the O Guangdong B-ORG Industry-University-Research I-ORG Institute I-ORG Cooperation I-ORG Project I-ORG 2010B090400453 O and O 2015A090905007 B-AWARD the O National B-ORG Science I-ORG I-ORG Technology I-ORG Pillar I-ORG Program I-ORG of I-ORG China I-ORG 2012BAD14B16-04 O the O Guangdong B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG of O Guangdong O Province O China O 2012B020310005 O and O 2015B090903077 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the B-ORG Chinese I-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG Pillar I-ORG Program I-ORG No: O 2012BAD39B0 B-AWARD the B-ORG Special I-ORG Fund I-ORG for I-ORG Innovation I-ORG Team I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG No: O ASTTP-IAS07 B-AWARD and O the B-ORG Chinese I-ORG National I-ORG Key I-ORG Basic I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG No: O 2014CB138804 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Key B-ORG Laboratory I-ORG Project I-ORG of I-ORG the I-ORG Clinical I-ORG Pharmacy I-ORG of I-ORG Jiangsu I-ORG Province I-ORG of I-ORG China I-ORG XZSYSKF2020027 B-AWARD G. O Z O the O Gusu B-ORG Medical I-ORG Key I-ORG Talent I-ORG Project I-ORG of I-ORG Suzhou I-ORG City I-ORG of I-ORG China I-ORG GSWS2020005 B-AWARD S. O H O the O New B-ORG Pharmaceutics I-ORG and I-ORG Medical I-ORG Apparatuses I-ORG Project I-ORG of I-ORG Suzhou I-ORG City I-ORG of I-ORG China I-ORG SLJ2021007 B-AWARD S. O H O the O Science B-ORG and I-ORG Technology I-ORG Development I-ORG Plan I-ORG Project I-ORG of I-ORG Suzhou I-ORG City I-ORG of O China O SYS2019007 B-AWARD G. O Z O and O the O Clinical B-ORG Medical I-ORG Expert I-ORG Team I-ORG Project I-ORG of I-ORG Suzhou I-ORG City I-ORG of I-ORG China I-ORG CSYJTD202101 B-AWARD J. O S O This O work O was O financially O supported O by O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDB31000000 O the O Special B-ORG Project I-ORG for I-ORG Basic I-ORG Work I-ORG in I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG No. O 2013FY111200 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31470151 B-AWARD and O the O Biological B-ORG Resources I-ORG Service I-ORG Network I-ORG Initiative I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG No. O ZSSD-015 B-AWARD This O research O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG 2019JJ50328 O the O Innovation B-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Hunan I-ORG Province I-ORG 2017SK50518 O a O scientific O research O program O of O the O Health B-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG Hunan I-ORG Province I-ORG C20180721 O and O a O scientific O research O program O of O the O Health B-ORG Commission I-ORG of I-ORG Hunan I-ORG Province I-ORG B2019061 O This O research O was O financially O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31670089 O CAS B-ORG Key I-ORG Program I-ORG ZDRW-ZS-2016-3M O Taishan B-ORG Scholars I-ORG Climbing I-ORG Program I-ORG of I-ORG Shandong I-ORG No. O TSPD20150210 B-AWARD CAS B-ORG Key I-ORG Laboratory I-ORG of I-ORG Renewable I-ORG Energy O Guangzhou O Institute O of O Energy O Conversion O No. O Y707kb1001 B-AWARD and O CAS B-ORG Key I-ORG Laboratory I-ORG of I-ORG Bio-based I-ORG Materials I-ORG No. O KLBM B-AWARD 2016008 O The O article O processing O charge O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81570584 O The O article O publication O charge O was O funded O by O Social B-ORG development I-ORG project I-ORG of I-ORG Jiangsu I-ORG Province(BE2015685 O Medical B-ORG Research I-ORG Funding I-ORG of I-ORG PLA(AWS14C003 O The O funding O bodies O did O not O participate O in O the O study O design O data O collection O data O analysis O results O interpretation O or O writing O of O the O manuscript O This O research O was O funded O by O China B-ORG Medical I-ORG Board O grant O number O 17-269 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 81601224 B-AWARD and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities O grant O number O xjj2018153 B-AWARD The O APC O was O funded O by O China O Postdoctoral O Science O Foundation O grant O number O 2018M643677 O This O study O was O supported O in O part O by O grants O from O Administration B-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG of I-ORG Sichuan I-ORG A2016N48 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81171780 O Foundation B-ORG for I-ORG Distinguished I-ORG Young I-ORG Scientists I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2016JQ0020 O Project B-ORG sub I-ORG topics I-ORG of I-ORG the I-ORG National I-ORG 863 I-ORG Project I-ORG 2015AA020303 O Scientific B-ORG research I-ORG fund I-ORG for I-ORG outstanding I-ORG young I-ORG scholars I-ORG of I-ORG Sichuan I-ORG University I-ORG 2014SCU04A12 O Sichuan B-ORG province I-ORG science I-ORG and I-ORG technology I-ORG support I-ORG plan I-ORG 2015SZ0049 O Science B-ORG and I-ORG technology I-ORG support I-ORG program I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2015FZ0040 O The O present O work O was O funded O by O Nature B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31572233 O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-46 O the B-ORG Hubei I-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Center I-ORG 2016620000001046 O Featuring B-ORG Talents I-ORG Cultivation I-ORG Project I-ORG 4611300108 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U1809213 O and O 11702113 B-AWARD Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG LQ18E030013 O and O LQ18E030014 B-AWARD and O Scientific B-ORG Research I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Provincial I-ORG Education I-ORG Department I-ORG Y201636479 O This O work O was O also O supported O by O the O Shaoxing O 330 O Talent O Plan O Foundation O ACX201424 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31901544 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0100801 O 2016YFD0101802 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20171279 O the O China B-ORG Agricultural I-ORG Research I-ORG System I-ORG CARS-03-03B O Each O of O the O funding O bodies O granted O the O funds O based O on O a O research O proposal O National O Key O Research O and O Development O Program O of O China O 2017YFD0100801 O 2016YFD0101802 O assisted O in O designing O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O Other O fundings O had O no O influence O over O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31560329 B-AWARD 31571521 B-AWARD 31371505 B-AWARD and O 82160286 O Ningxia O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Ningxia I-ORG Province I-ORG 2020AAC03179 O and O 2021BEB04041 B-AWARD Science B-ORG Research I-ORG Project I-ORG of I-ORG Ningxia I-ORG Higher I-ORG Education I-ORG NGY2020048 O and O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Ningxia I-ORG Hui I-ORG Autonomous I-ORG Region I-ORG 2019BEG03002 O and O 2019BFG02007 B-AWARD This O research O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31560091 O the B-ORG Key I-ORG project I-ORG of I-ORG the I-ORG Education I-ORG Department I-ORG of I-ORG Guizhou I-ORG Province I-ORG KY(2013)186 O and O Key B-ORG joint I-ORG fund I-ORG of I-ORG the I-ORG Kaili I-ORG University I-ORG and I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Guizhou I-ORG Province I-ORG LH(2015)7754 O The O laboratory O test O and O analysis O of O indexes O in O pre-experiment O was O supported O by O the O Shandong O Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG China O under O Grant O No. O ZR2014HP046 O the O enrollment O of O patients O and O the O laboratory O test O of O biomarkers O were O supported O by O the O Shandong O Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Programme I-ORG Foundation I-ORG China O under O Grant O No. O 2017WS462 O and O Shandong O Provincial I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Programme I-ORG Foundation I-ORG China O under O Grant O No. O 2018GSF118009 O the O data O analysis O and O the O polish O fee O were O supported O by O the O Technology O Programme I-ORG Foundation I-ORG of I-ORG Jinan I-ORG China O under O Grant O No. O 201821007 O This O study O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31501785 B-AWARD 31701958 I-AWARD and I-AWARD 31772354 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG No. O QC2017026 B-AWARD University B-ORG Nursing I-ORG Program I-ORG for I-ORG Young I-ORG Scholars I-ORG with I-ORG Creative I-ORG Talents I-ORG in I-ORG Heilongjiang I-ORG Province I-ORG UNPYSCT-2017023 O and I-AWARD UNPYSCT-2018102 O and O “Academic O backbone” O Project O of O Northeast O Agricultural O University O 18XG07 O This O work O was O supported O by O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG B) I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDB15030302 O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 I-ORG Program I-ORG 2015CB150802 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31200479 O 31570620 O US O National B-ORG Science I-ORG Foundation I-ORG Grant O No. O DEB-1354098 O This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31660636 O 31801089 I-AWARD 41620104007 I-AWARD 31661143020 O the O Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG 1610322017003 O the O National B-ORG Program I-ORG for I-ORG Support I-ORG of I-ORG Top-notch I-ORG Young I-ORG Professionals I-ORG the I-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG CAAS-ASTIP-2014-LIHPS-01 O the O Fok B-ORG Ying I-ORG Tung I-ORG Education I-ORG Foundation I-ORG 151105 O and O the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-37 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81974078 B-AWARD 81570530 B-AWARD 81370550 B-AWARD to O Ling O Yang O the O Department B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Hubei I-ORG Provincial I-ORG People’s I-ORG Government I-ORG No. O 2019ACA133 B-AWARD to O Ling O Yang O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG No. O 2018ADC073 B-AWARD to O Rui O Yang O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O The O Shandong B-ORG Provincial I-ORG Modern I-ORG Agriculture I-ORG Industry I-ORG Technology I-ORG System I-ORG SDAIT-10 O Funds B-ORG of I-ORG the I-ORG Shandong I-ORG “Double I-ORG Tops” I-ORG Program I-ORG SYL2017YSTD12 O the O National B-ORG key I-ORG R I-ORG I-ORG D I-ORG plan I-ORG Integration O and O Demonstration O of O Key O Technologies O for O Large-scale O Efficient O and O Safe O Breeding O of O Goats O 2018YFD0501906 O and O the O project B-ORG of I-ORG improved I-ORG agricultural I-ORG varieties I-ORG in I-ORG Shandong I-ORG Province I-ORG 2019LZGC012 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O under O Grant O No. O 61902238 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG under O Grant O No. O 2021M692493 B-AWARD and O the O Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Plan I-ORG Project I-ORG under O Grant O No. O 22692194600 B-AWARD This O work O was O supported O by O the O National B-ORG Institute I-ORG of I-ORG Neurological I-ORG Disorders I-ORG and I-ORG Stroke I-ORG K08NS097624 O the O National B-ORG Resource I-ORG for I-ORG Translational I-ORG and I-ORG Developmental I-ORG Proteomics I-ORG P41 O GM108569 O National B-ORG Cancer I-ORG Institute I-ORG CCSG O P30 I-AWARD CA060553 O the O Sherman O Fairchild O Foundation O the O Northwestern O Proteomics O Core O Facility O the O Pediatric O Cancer O Research O Foundation O the O Frankel O Foundation O the O Lurie O Children’s O Hospital O Faculty O Practice O Plan O and O Northwestern O University O Clinical O and O Translational O Sciences O Institute O Adult O tissue O was O provided O by O the O Northwestern O Nervous O System O Tumor O Bank O which O is O supported O by O the O P50CA221747 O SPORE O for O Translational O Approaches O to O Brain O Cancer O This O work O was O supported O by O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2012CB316503 O National B-ORG High-Tech I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2014AA021103 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31271402 O and O 31522030 B-AWARD and O Tsinghua B-ORG University I-ORG Initiative I-ORG Scientific I-ORG Research I-ORG Program I-ORG 2014z21045 O This O work O was O also O supported O by O the O Computing O Platform O of O National O Protein O Facilities O Tsinghua O University O The O funding O for O open O access O was O provided O by O the O National O Natural O Science O Foundation O of O China O 31271402 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Fund I-ORG of I-ORG China I-ORG No. O 81473772 B-AWARD National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2013CB531906 O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O LQ15H270003 B-AWARD Supported O by O the B-ORG key I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Team I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2013TD15 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 81625016 B-AWARD 81871940 I-AWARD 81902417 O Scientific B-ORG Innovation I-ORG Project I-ORG of I-ORG Shanghai I-ORG Education I-ORG Committee I-ORG 2019-01-07-00-07-E00057 O the O Shanghai B-ORG Natural I-ORG Science I-ORG Foundation I-ORG grant O number O 17ZR1406300 B-AWARD the O Shanghai B-ORG Cancer I-ORG Center I-ORG Foundation I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG grant O number O YJJQ201803 B-AWARD and O the O Fudan B-ORG University I-ORG Personalized I-ORG Project I-ORG for I-ORG “Double I-ORG Top” I-ORG Original I-ORG Research I-ORG grant O number O XM03190633 B-AWARD This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81490745 B-AWARD to O HY O the O Major B-ORG National I-ORG Scientific I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2015CB943304 B-AWARD to O HY O the O Beijing B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG Grant O No. O Z151100001615051 B-AWARD to O HY O and O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG of O China O Grant O No. O 2015BAI13B06 B-AWARD to O HY O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O in O part O by O Youth B-ORG Foundation I-ORG Project I-ORG of I-ORG Humanities I-ORG and I-ORG social I-ORG sciences I-ORG research I-ORG program I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG 17YJCZH250 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2572015CB13 O Heilongjiang B-ORG Province I-ORG Philosophy I-ORG and I-ORG Social I-ORG Sciences I-ORG Planning I-ORG Project I-ORG 14B015 O and O Opening O Foundation O of O Intelligent O Transportation O Information O Sensing O and O Data O Analysis O Engineering O Laboratory O for O Jiangsu O Province O National O key O research O and O development O program O key O projects O of O international O scientific O and O technological O innovation O cooperation O between O governments O 2016YFE0108000 O This O study O was O funded O by O a O grant O from O the O National B-ORG Cancer I-ORG Institute I-ORG titled O Cancer O Research O Network O CRN O Across O Health O Care O Systems O U19 O CA079689 O Dr. O Mazor O currently O receives O funding O from O a O subsequent O grant O the O Cancer B-ORG Research I-ORG Resources I-ORG I-ORG Collaboration I-ORG in I-ORG Integrated I-ORG Health I-ORG Care I-ORG Systems I-ORG U24 B-AWARD CA171524 O which O funds O the O fourth O cycle O of O the O CRN O The O CRN O welcomes O collaboration O with O external O investigators O and O institutions O For O more O information O about O how O to O collaborate O with O the O CRN O please O visit O crn.cancer.gov O The O funder O had O no O role O in O study O design O data O collection O analysis O and O interpretation O of O data O writing O of O this O manuscript O or O the O decision O to O submit O this O paper O for O publication O Dr. O Cutrona O is O supported O by O the O National B-ORG Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences I-ORG of O the O National O Institutes O of O Health O under O award O number O KL2TR000160 B-AWARD The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O NIH O This O study O was O supported O by O the B-ORG National I-ORG Scientific I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81522048 B-AWARD 81573511 B-AWARD 81874329 B-AWARD and O 31801121 B-AWARD the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG Nos O 2016YFC0905000 B-AWARD 2016YFC0905001 B-AWARD and O Scientific B-ORG Foundation I-ORG of I-ORG Xiang I-ORG Ya I-ORG hospital I-ORG 2016Q04 O This O work O was O supported O by O NSFC B-ORG U1605212 O 31761130074 B-AWARD to O Y.Q O Fujian B-ORG Innovative I-ORG Center I-ORG for I-ORG Germplasm I-ORG Resources I-ORG and I-ORG Innovation I-ORG Project I-ORG of I-ORG Characteristic I-ORG Horticultural I-ORG Crop I-ORG Seed I-ORG Industry I-ORG KLA15001D O and O FAFU B-ORG international I-ORG collaboration I-ORG project I-ORG KXb16006A O The O Project O Supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0200402 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Program O No. O 31401735 B-AWARD and O Natural B-ORG Science I-ORG Basic I-ORG Research I-ORG Plan I-ORG in I-ORG Shaanxi I-ORG Province I-ORG of I-ORG China I-ORG Program O No. O 2017JM3030 B-AWARD This O research O was O funded O by O Universiti B-ORG Sains I-ORG Malaysia I-ORG and O the O Malaysian O Ministry O of O Higher O Education O under O the O Research O University O RU) O grant O 1001.CDADAH.8011024 O and O HICoE B-ORG programme I-ORG 311/CDADAH/4401009 O respectively O The O research O was O partly O supported O by O start-up O funds O from O the O College B-ORG of I-ORG Pharmacy I-ORG the I-ORG University I-ORG of I-ORG South I-ORG Carolina I-ORG USA O as O well O as O the O NIH O grant O 5P20GM109091 O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG nos O 81401512 B-AWARD and I-AWARD 41606186 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Provience I-ORG 2017A030313235 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG no. O 2016M602419 B-AWARD and O the O Hong B-ORG Kong I-ORG Scholars I-ORG Program I-ORG no. O XJ2015022 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. I-AWARD 81471324 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grant O No. I-AWARD BK20191127 O the O Jiangsu B-ORG Commission I-ORG of I-ORG Health I-ORG Grant O No. I-AWARD H2018062 O and O the O Nanjing B-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG Grant O No. I-AWARD 201911044 O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFA0602403 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 41775103 O and O Beijing B-ORG Municipal I-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 9172010 O This O work O was O funded O by O the O Consejo B-ORG Nacional I-ORG de I-ORG Ciencia I-ORG y I-ORG Tecnología I-ORG Conacyt O México O “Fronteras O de O la O Ciencia” O project O 1570 B-AWARD AF-D B-ORG CE-S B-ORG and O FC-H B-ORG acknowledge O Conacyt O scholarship O for O PhD O studies O grant O numbers O 700545 B-AWARD 630487 B-AWARD and O 707294 B-AWARD respectively O This O study O was O supported O in O part O by O the O Foundation B-ORG of I-ORG the I-ORG Education I-ORG Department I-ORG of I-ORG Hunan I-ORG 11C0141 O 15C0513 B-AWARD 16C0162 B-AWARD the B-ORG key I-ORG Foundation I-ORG of I-ORG the I-ORG Education I-ORG Department I-ORG of I-ORG Hunan I-ORG 15A023,16A027 O National B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG province I-ORG 2015JJ6010 O Foundation B-ORG of I-ORG the I-ORG health I-ORG department I-ORG of I-ORG Hunan I-ORG B2016096 O and O the O construct O program O of O the O key O discipline O in O Hunan O province O This O work O was O supported O by O Senter B-ORG Novem I-ORG Contract O no. O FND07003 B-AWARD Product B-ORG Boards I-ORG for I-ORG Livestock I-ORG and I-ORG Meat I-ORG Contract O no. O 13.31.001 B-AWARD Netherlands B-ORG Organization I-ORG for I-ORG Research I-ORG and I-ORG Development I-ORG ZonMw I-ORG Contract O no. O 50-51700-98-053 B-AWARD and O by O the O 1Health4Food O 1H4F O project O under O the O ESBLAT O consortium O TKI-AF-12067 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21571147 O 51808414 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG 2018CFB108 O Hubei O Collaborative O Innovation O Center O for O Down-Streaming O Products O in O Ethylene O Project O and O Process O Intensification O Outstanding O Young O and O Middle-aged O Scientific O Innovation O Team O of O Colleges O and O Universities O of O Hubei O Province O Biomass O chemical O technologies O and O materials O Grant O No. O T201908 O and O Graduate B-ORG Innovative I-ORG Fund I-ORG of I-ORG Wuhan I-ORG Institute I-ORG of I-ORG Technology I-ORG CX2018002 O V.C O acknowledges O the O financial O support O of O Khalifa O University O of O Science O and O Technology O through O CIRA-2018-02 O This O research O is O supported O by O the O Defense B-ORG Advanced I-ORG Research I-ORG Projects I-ORG Agency I-ORG DARPA O Warrior O Web O Program O W911NF-14-C-0051 O The O views O and O conclusions O contained O in O this O document O are O those O of O the O authors O and O should O not O be O interpreted O as O representing O the O official O policies O either O expressly O or O implied O of O DARPA O or O the O U.S O Government O This O work O was O also O funded O by O the O National B-ORG Science I-ORG Foundation I-ORG CNS-1446464 O and O DGE1144152 B-AWARD and O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG K12HD073945 O This O work O was O also O partially O funded O by O the O Wyss O Institute O the O John O A. O Paulson O School O of O Engineering O and O Applied O Sciences O at O Harvard O University O O the O Vanderbilt O University O School O of O Engineering O HL O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG no. O LC2017016,http://www.hljkjt.gov.cn B-AWARD the O Merit-based B-ORG Funding I-ORG for I-ORG Returned I-ORG Oversea I-ORG Students I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG no. O 2017QD0016,http://www.hljkjt.gov.cn B-AWARD the O Harbin B-ORG Special I-ORG Fund I-ORG for I-ORG Innovative I-ORG Talents I-ORG in I-ORG Science I-ORG and I-ORG Technology I-ORG no. O 2016RAXYJ072,https://kjglxt.harbin.gov.cn B-AWARD and O the O Elite B-ORG Youth I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG CAASQNYC-KYYJ-56,http://www.caas.cn/en/scientists/talent_program O SWL O was O supported O by O the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG Grant O No. O CARS-40-K18,http://www.moa.gov.cn B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81672054 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017A030313120 O the O Research O Team O Program O of O the O Natural O Science O Foundation O of O Guangdong O 2014A030312016 O and O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M633078 O The O ZIBRA-2 O project O is O funded O by O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG grant O 440685/2016-8 B-AWARD and O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG grant O 88887.130716/2016-00 B-AWARD FGN O is O funded O by O Conselho O Nacional O de O Desenvolvimento O Científico O e O Tecnológico O http://www.cnpq.br O grant O 440856/2016-7 O and O Coordenação O de O Aperfeiçoamento O de O Pessoal O de O Nível O Superior O http://www.capes.gov.br O grants O 88881.130825/2016-00 O and O 88887.130823/2016-00 O L.C.J.A O is O supported O by O the O EU’s O Horizon O 2020 O Programme O through O ZIKAlliance O grant O PRES-005-FEX-17-4-2-33 O N.R.F O is O funded O by O a O Royal O Society O and O Wellcome B-ORG Trust I-ORG Sir O Henry O Dale O Fellowship O 204311/Z/16/Z O internal O GCRF O grant O 005073 O and O John O Fell O Research O Fund O grant O 005166 O This O research O received O funding O from O the O ERC O grant O agreement O 614725-PATHPHYLODYN O MS O was O partially O supported O by O the O National O Institute O of O General O Medical O Sciences O of O the O NIH O USA O under O award O number O R01GM130668 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O CAMS B-ORG Innovation O Fund O for O Medical O Sciences O No. O 2016-I2M-3-013 B-AWARD the O ‘Significant O New I-ORG Drug I-ORG Development’ I-ORG Major I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Projects O of O China O No. O 2014ZX09201042-003 O and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program O of O China O 2016YFA0201504 O This O study O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0504603 O and O the O National B-ORG Natural I-ORG Science I-ORG Fund I-ORG 31672473 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG lzujbky-2017-it12 O lzujbky-2018-it12 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the O Bio O O Medical O Technology O Development O Program O of O the O National O Research O Foundation O NRF O funded O by O the O Korean B-ORG government I-ORG MSIT O NRF-2019M3E5D1A02067951 O to O Cheol-Kyu O Park O a O grant O from O the O Chonnam B-ORG National I-ORG University I-ORG Hwasun I-ORG Hospital I-ORG Institute I-ORG for I-ORG Biomedical I-ORG Science I-ORG HCRI O 21018 I-AWARD to O Cheol-Kyu O Park O and O a O grant O from O the O Chonnam B-ORG National I-ORG University I-ORG Hospital I-ORG Biomedical I-ORG Research I-ORG Institute I-ORG BCRI202109-85 O to O Nakyung O Jeon O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 12102088 B-AWARD National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2021YFB2011100 B-AWARD National O Natural O Science O Foundation O of O China O Grant O No. O 51975110 B-AWARD Liaoning B-ORG Revitalization I-ORG Talents I-ORG Program I-ORG Grant O No. O XLYC1907171 B-AWARD and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No. O N2003005 B-AWARD This O work O was O supported O by O the O Collaborative B-ORG Innovation I-ORG Project I-ORG of I-ORG Universities I-ORG in I-ORG Anhui I-ORG Province I-ORG GXXT-2021-054 O the O Graduate B-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG Anhui I-ORG Province I-ORG in I-ORG 2021 I-ORG YJS20210247 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32272703 O the O Performance B-ORG Award I-ORG of I-ORG Anhui I-ORG Pakchoi I-ORG Germplasm I-ORG Resource I-ORG Bank I-ORG Nursery I-ORG Project I-ORG 21432003 O the O University B-ORG Natural I-ORG Science I-ORG Research I-ORG Project I-ORG of I-ORG Anhui I-ORG Province I-ORG KJ2020ZD11 O and O the O Nature B-ORG Fund I-ORG of I-ORG Anhui I-ORG Province I-ORG 2008085MC80 O This O study O was O supported O by O the O project O of O the O Technology B-ORG Agency I-ORG of I-ORG the I-ORG Czech I-ORG Republic I-ORG TE02000058 O the O project O of O the O Ministry B-ORG of I-ORG Health I-ORG of I-ORG the I-ORG Czech I-ORG Republic I-ORG FNB O RVO I-AWARD 65269705 O the O project O CEITEC B-ORG 2020 I-ORG LQ1601 O and O the O project O of O the O Grant B-ORG Agency I-ORG of I-ORG the I-ORG Czech I-ORG Republic I-ORG GA16-11619S/2016 O This O work O was O jointly O supported O by: O 1) O Humanities B-ORG and I-ORG Social I-ORG Science I-ORG Research I-ORG Project I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG No. O 18YJCZH130 O 2) O the B-ORG Social I-ORG Science I-ORG Planning I-ORG Fund I-ORG Project I-ORG of I-ORG Xi’an I-ORG in I-ORG 2020 I-ORG No. O JG96 O 3) O the B-ORG Nature I-ORG Science I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG Shaanxi I-ORG Province I-ORG No. O 2020JQ-397 O and O 4) O The B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG CHD I-ORG No. O 300102228202 I-AWARD 300102229666 O This O work O was O supported O by O a O grant O obtained O from O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81303287 O 81503317 B-AWARD the O Guangdong B-ORG Provincial I-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2016A020215133 O and O the O Hospital B-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG YN2015MS12 O This O work O was O supported O by O the O Coordination B-ORG and I-ORG Improvement I-ORG of I-ORG Higher I-ORG Level I-ORG or I-ORG Education I-ORG Personnel I-ORG CAPES I-ORG Scholarship I-ORG Processes I-ORG 1382439/2014 B-AWARD and O the O National B-ORG Council I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Development I-ORG CNPq I-ORG Process I-ORG 310614/2013-9 B-AWARD and O by O the O Carlos B-ORG Chagas I-ORG Filho I-ORG Research I-ORG Support I-ORG Foundation I-ORG FAPERJ I-ORG Process I-ORG 202.994/2015 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51175454 O Key B-ORG Science-Technology I-ORG Team I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2011R50005 O and O Zhejiang B-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG 2012C11002 O It O is O ZJ O who O received O the O funding O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Research O Fund O for O the O Control B-ORG of I-ORG Infectious I-ORG Diseases I-ORG Commissioned I-ORG Study I-ORG of I-ORG Food I-ORG and I-ORG Health I-ORG Bureau I-ORG of I-ORG Hong I-ORG Kong I-ORG Government I-ORG RFCID O HK-09-01-21 B-AWARD Health B-ORG and I-ORG Medical I-ORG Research I-ORG Fund I-ORG HMRF O HKM-15-M09 B-AWARD a O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 O Program O 2014CB745202 B-AWARD from O the B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG PRC I-ORG and I-ORG by I-ORG Shenzhen I-ORG Peacock I-ORG project I-ORG 201503313000502 O This O work O was O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG R I-ORG I-ORG D) I-ORG Plan I-ORG of I-ORG China I-ORG No. O 2018YFD0200802 O Agriculture B-ORG Research I-ORG System I-ORG of I-ORG China I-ORG CARS-9-P20 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG 2015J01086 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O has O received O funding O from O the O European B-ORG Union’s I-ORG Horizon I-ORG 2020 I-ORG research I-ORG and I-ORG innovation I-ORG programme I-ORG under O grant O agreement O No. O 727922 B-AWARD DELTAFLU O and O grant O agreement O No. O 731014 B-AWARD VetBioNet—Veterinary O Biocontained O facility O Network O This O study O was O further O made O possible O through O funding O provided O by O the O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG under O project O numbers O BBS/E/D/10002071 B-AWARD and O BBS/E/D/20002174 B-AWARD and O a O National B-ORG Capability I-ORG Grant I-ORG to I-ORG the I-ORG NARF I-ORG BB/J004219/1 O For O the O purpose O of O open-access O research O the O author O has O applied O a O CC O BY O public O copyright O licence O to O any O Author-Accepted O Manuscript O version O arising O from O this O submission O This O research O work O was O funded O by O the O earmarked O fund O for O Modern B-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG No. O CARS-35-05 B-AWARD the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG 973 I-ORG program I-ORG in I-ORG China I-ORG No. O 2014CB138705 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 31372363 O XZ O is O the O funder O who O had O role O in O study O design O and O decision O to O publish O This O study O was O supported O by O the B-ORG Medical I-ORG Research I-ORG Project I-ORG jointly I-ORG funded I-ORG by I-ORG Chongqing I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG and I-ORG Chongqing I-ORG Health I-ORG Commission I-ORG 2019ZDXM046 O the B-ORG Technological I-ORG Innovation I-ORG and I-ORG Application I-ORG Demonstration I-ORG Special I-ORG Project I-ORG of I-ORG Chongqing I-ORG cstc2018jscx-mszdX0012 O and O the B-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG Special I-ORG Project I-ORG of I-ORG Army I-ORG Medical I-ORG University I-ORG 2019XLC2006 O This O work O was O supported O by O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG Projects I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BE2022373 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31971689 O and O the B-ORG Priority I-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O This O research O was O funded O by O BIM B-ORG Engineering I-ORG Center I-ORG of I-ORG Anhui I-ORG Province O grant O number O AHBIM2021KF01 B-AWARD Fundamental B-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG Central I-ORG South I-ORG University O grant O number O 2021zzts0245 B-AWARD China B-ORG Railway I-ORG Group I-ORG Limited O grant O number O 2021-ZD-06 B-AWARD and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 72171237 B-AWARD This O research O was O funded O by O the O Croatian B-ORG Science I-ORG Foundation I-ORG Hrvatska O Zaklada O za O Znanost O CSF O grant O IP-2016-06-7060 B-AWARD to O MM, O the O financial O support O from O the O University B-ORG of I-ORG Rijeka I-ORG uniri-prirod-18-290-1463 O to O J.B O uniri-biomed-18-258-6427 B-AWARD and O uniri-sp-biomed-19-50-1560 B-AWARD to O M.M O G.F O acknowledges O the O support O of O the O European B-ORG Research I-ORG Council O ERC O under O consolidator O grant O number O 588279 B-AWARD InCell/ERC B-ORG and O the O Swiss O National O Science O Foundation O under O grant O number O 200021_182562 B-AWARD This O project O has O received O funding O from O the O European B-ORG Union’s I-ORG Horizon I-ORG 2020 I-ORG research I-ORG and I-ORG innovation I-ORG programme O under O the O Marie O Skłodowska-Curie O grant O agreement O No. O 945363 B-AWARD Medical B-ORG Research I-ORG Council I-ORG NIA O G0400341 B-AWARD and O G0700399 B-AWARD The O Royal B-ORG Society I-ORG RG081218 O Royal B-ORG Society I-ORG Wolfson I-ORG Research I-ORG Merit I-ORG Award I-ORG NIH O RO1 O MH O 081990 B-AWARD and O European B-ORG Commission I-ORG Marie I-ORG Curie I-ORG Early I-ORG Career I-ORG Training I-ORG Network I-ORG MC-ITN-264301 O TRACKDEV O The O Wellcome B-ORG Trust I-ORG Centre I-ORG for I-ORG Neuroimaging I-ORG is O supported O by O core O funding O from O the O Wellcome O Trust O 091593/Z/10/Z O This O paper O was O supported O by O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81701899 O the O Youth O Incubation O Plan O of O the O Military B-ORG Medical I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 16QNP091 O and O the O Naval B-ORG Medical I-ORG University I-ORG Youth I-ORG Start-up I-ORG Fund I-ORG 2016QN10 O This O research O was O funded O by O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG LY18E010006 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51605440 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017M621966 O and O Zhejiang O province O commonweal O technology O research O project O LGG19E050021 O The O authors O acknowledge O the O financial O support O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Program O No. O 51602111 B-AWARD the O Xijiang O R&D O Team O X.W O the O Guangdong B-ORG Provincial I-ORG Grant I-ORG No. O 2017A010104013 B-AWARD the O Guangdong B-ORG Innovative I-ORG and I-ORG Entrepreneurial I-ORG Team I-ORG Program I-ORG No. O 2016ZT06C517 B-AWARD the O Special O Fund O Project O of O Science O and O Technology O Application O in O Guangdong O No. O 2017B020240002 B-AWARD and O the O National O 111 O project O This O study O was O supported O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH O grants O R01HD088558 B-AWARD and O R01HG009124 B-AWARD and O National B-ORG Science I-ORG Foundation I-ORG NSF O grants O DMS1712933 B-AWARD and O BCS1751783 B-AWARD YF O is O also O supported O by O a O scholarship O from O the O China O Scholarship O Council O Computing O in O this O study O is O supported O in O part O by O the O North B-ORG Carolina I-ORG Biotechnology I-ORG Center I-ORG Grant O 2016-IDG-1013 B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O nos O 31801200 B-AWARD and O 31801137 O Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG ZR2017BC052 O Shandong O Key O Laboratory O of O Animal O Resistance O Biology O Open O fund O 2017KF06 O and O Postdoctoral B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 2017M612334 O This O work O was O supported O by O Grants O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Fund I-ORG 30770865 O 81170287 B-AWARD Beijing B-ORG Lisheng I-ORG Cardiovascular I-ORG Health I-ORG Foundation I-ORG BYX-2013-019 O the B-ORG China-Japan I-ORG Friendship I-ORG Hospital I-ORG Youth I-ORG Science I-ORG and I-ORG Technology I-ORG Excellence I-ORG Project I-ORG 2014-QNYC-B-13 O and O the B-ORG China-Japan I-ORG Friendship I-ORG Hospital I-ORG research I-ORG topic I-ORG within I-ORG the I-ORG hospital I-ORG 2014-4-MS-23 O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 52173016 O the B-ORG State I-ORG Key I-ORG Research I-ORG Development I-ORG Programme I-ORG of I-ORG China I-ORG Grant O No. O 2021YFB3800701 B-AWARD GuangDong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG 2019B1515120063 O and O PetroChina B-ORG Scientific I-ORG and I-ORG Technological I-ORG Projects I-ORG 2020B-2512 O 2021DJ5902 B-AWARD and O 2020-CB-02-13 B-AWARD This O study O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81373156 O 81471583 I-AWARD and I-AWARD 81570587 O Guangdong B-ORG Provincial I-ORG international I-ORG Cooperation I-ORG Base I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Organ O Transplantation O 2015B050501002 O Guangdong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Funds I-ORG for I-ORG Major I-ORG Basic I-ORG Science I-ORG Culture I-ORG Project I-ORG 2015A030308010 O Pearl B-ORG River I-ORG Nova I-ORG Program I-ORG of I-ORG Guangzhou I-ORG 201506010014 O the B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG 201704020150 O and O the B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Huizhou I-ORG 170520181743174 O The O funding O bodies O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O The O work O is O supported O by O theNational O Key I-ORG Research I-ORG and I-ORG Development I-ORG Program(2017YFC1703506 O 2017YFC1700106 O theFundamental O Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities(2017YJS057 O 2017JBM020 B-AWARD theSpecial O Programs I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine(201407001 O JDZX2015170 B-AWARD and O JDZX2015171 B-AWARD theNational O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China(81703945 O and O theNational O Key I-ORG Technology I-ORG R&D I-ORG Program(2013BAI02B01 O and O 2013BAI13B04 B-AWARD This O work O was O supported O by O a O grant O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31400488 O by O the B-ORG Applied I-ORG Basic I-ORG Research I-ORG Project I-ORG of I-ORG Yunnan I-ORG Province I-ORG Grant I-ORG 2016FB055 O and O by O the B-ORG Yunnan I-ORG Academy I-ORG of I-ORG Forestry I-ORG Innovation I-ORG Fund I-ORG Project O Grant O QN2018-01 O This O work O was O supported O by O grants O from O the O Norwegian B-ORG Health I-ORG Region I-ORG South I-ORG East I-ORG Grant O Number O 2010021 B-AWARD the O Norwegian B-ORG Research I-ORG Council I-ORG Grant O Numbers O 244388 B-AWARD and O 254817 B-AWARD the O Norwegian B-ORG Ministry I-ORG of I-ORG Health I-ORG Gene O Therapy I-AWARD Grant O This O work O was O supported O by O a O grant O from O the O 2015 B-ORG Welfare I-ORG Scientific I-ORG Research I-ORG Project I-ORG from I-ORG the I-ORG Chinese I-ORG Ministry I-ORG of I-ORG Health I-ORG 2015SQ00050 O Key B-ORG joint I-ORG research I-ORG project I-ORG of I-ORG Chinese I-ORG Ministry I-ORG of I-ORG Health I-ORG I-ORG Zhejiang I-ORG Province I-ORG NO. O 2018271879 B-AWARD Welfare B-ORG scientific I-ORG research I-ORG project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG NO. O LGF18H150003 B-AWARD and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81571916 O 81372079 B-AWARD The O funding O bodies O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O numbers O 51709165 B-AWARD 51579025 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province O grant O number O 20170540090 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities O grant O number O 3132019306 B-AWARD The O research O is O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG grant O no. O 2018YFD0500600 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG grant O no. O 2018CFA071 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 31572409 B-AWARD This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2019YFD1001601 O 2018YFD1000601 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31171608 O the B-ORG Special I-ORG Innovative I-ORG Province I-ORG Construction I-ORG in I-ORG Anhui I-ORG Province I-ORG 15czs08032 O the B-ORG Special I-ORG Project I-ORG for I-ORG Central I-ORG Guiding I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG of I-ORG Region I-ORG in I-ORG Anhui I-ORG Province I-ORG 2016080503B024 O This O work O was O supported O by O the O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31671823 O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG as I-ORG a I-ORG Whole I-ORG Plan I-ORG Projects I-ORG of I-ORG Shaanxi I-ORG Province I-ORG China I-ORG 2015KTCQ02-01 O the B-ORG Development I-ORG Program I-ORG for I-ORG Innovative I-ORG Research I-ORG Team I-ORG of I-ORG Shaanxi I-ORG Normal I-ORG University I-ORG China I-ORG GK201501006 O This O work O was O supported O by O Italian O MIUR O project O 2015MP34H3 O Spanish B-ORG MICINN I-ORG and I-ORG MEC I-ORG and O FEDER B-ORG funds O from O the O European O Union O CTQ2016-78499-C6-1-R O and O CTQ2017-90852-REDC O Unidad O de O Excelencia O María O de O Maeztu O MDM-15-0538 O Generalitat B-ORG Valenciana I-ORG PROMETEO O II I-AWARD 2015-002 O Spanish O Ministerio O de O Ciencia O Innovación O y O Universidades O Project O MAT2014-60104-C2-2-R O Autonomous O Regional O Government O Junta O de O Andalucía O Group O PAIDI O FQM273 O the O University B-ORG of I-ORG Valencia I-ORG Subprograma O Atracció I-AWARD de I-AWARD Talent O and O the O University O of O Jaén O Action O 1_PAIUJA O 2018-2019 O EI_FQM6-2018 O This O research O was O supported O by O Grants O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O nos O 2019YFA0904600 B-AWARD 2018YFA0903000 B-AWARD and O 2018YFA0903600 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG nos O 91751102 B-AWARD 31901016 B-AWARD 31770035 B-AWARD 31770100 B-AWARD 31972931 B-AWARD 21621004 B-AWARD 31370115 B-AWARD and O 31470217 B-AWARD and O Tianjin B-ORG Synthetic I-ORG Biotechnology I-ORG Innovation I-ORG Capacity I-ORG Improvement I-ORG Project I-ORG no. O TSBICIP-KJGG-007 B-AWARD This O study O was O supported O by O the B-AWARD Support I-AWARD Project I-AWARD of I-AWARD Strategic I-AWARD Research I-AWARD Center I-AWARD in I-AWARD Private I-AWARD Universities I-AWARD from O the O Ministry B-ORG of I-ORG Education I-ORG Culture I-ORG Sports I-ORG Science I-ORG and I-ORG Technology I-ORG MEXT O grants O from O the O Japan B-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG 15K15353 O to O S.I O and O 17H04205 B-AWARD to O K.H.-I O and O Practical O Research O for O Innovative O Cancer O Control O JP18ck0106194 O to O K.I O and O Project O for O Cancer O Research O and O Therapeutic O Evolution O P-CREATE O JP18cm0106144 B-AWARD to O S.I O from O the O Japan B-ORG Agency I-ORG for I-ORG Medical I-ORG Research I-ORG and I-ORG Development I-ORG AMED O This O study O was O supported O by O grants O from O the O Beijing B-ORG Nova I-ORG Program I-ORG No. O Z181100006218020 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81603238 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG public I-ORG welfare I-ORG research I-ORG institutes I-ORG No. O ZXKT17049 B-AWARD This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China(31401041 O to O ZS O and O 91319304 O to O YF O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG http://www.most.gov.cn/eng/index.htm O 2016YFD0100902 O and O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG http://english.cas.cn/)(XDPB0403 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O NSFC B-ORG – I-ORG Guangdong I-ORG Joint I-ORG Foundation I-ORG grant O number O U1401223 B-AWARD CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG grant O number O 2016-I2M-1-012 B-AWARD and O Guangdong B-ORG YangFan I-ORG Innovative I-ORG I-ORG Enteprencurial I-ORG Research I-ORG Team I-ORG Project I-ORG grant O number O 2017YT05S029 B-AWARD This O work O was O supported O by O the O JST-PRESTO B-ORG 11102645 O to I-AWARD S.M O the O JST-CREST B-ORG JPMJCR1854 O M.Y B-AWARD MEXT/JSPS B-ORG KAKENHI I-ORG Grants O 16H06461 O 15H05772 B-AWARD to I-AWARD M.Y O 18H04563 B-AWARD 17H05579 B-AWARD 17H04020 B-AWARD to I-AWARD W.K O and B-AWARD 17K07048 I-AWARD to I-AWARD S.M O the O AMED B-ORG 16dm0107124h0001 O to I-AWARD W.K O and O the O Takeda O Science O Foundation O W.K O The O work O was O supported O by O funding O from O the O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG 22ZR1430000 B-AWARD Shanghai B-ORG Jiao I-ORG Tong I-ORG University I-ORG YG2022QN063 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 62022056 B-AWARD This O work O was O funded O by O National B-ORG Institutes I-ORG of I-ORG Health I-ORG T32 B-AWARD HD07418,https://www.nih.gov O National B-ORG Institute I-ORG of I-ORG Biomedical I-ORG Imaging I-ORG and I-ORG Bioengineering I-ORG U01 B-AWARD EB015410-01A1,https://www.nibib.nih.gov O and O National B-ORG Institute I-ORG of I-ORG Arthritis I-ORG and I-ORG Musculoskeletal I-ORG and I-ORG Skin I-ORG Diseases I-ORG R01 B-AWARD AR069176-01A1,https://www.niams.nih.gov O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U1333119 O 51605424 O Defense B-ORG Industrial I-ORG Technology I-ORG Development I-ORG Program I-ORG JCKY2013605B002 O Fund O of O Shanghai O Engineering O Research O Center O of O Civil O Aircraft O Health O Monitoring O GCZX-2015-05 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 56XBC18206 O 56XBA18201 O Six O Talent O Peaks O Project O in O Jiangsu O Province O of O China O JXQC-018 O and O Postgraduate O Research O O Practice O Innovation O Program O of O Jiangsu O Province O KYCX18_0309 O This O research O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O NO: O 2016YFC0900803 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O NO: O 81573243 B-AWARD 81602925 I-AWARD U1304821 O Henan B-ORG Provincial I-ORG Science I-ORG Fund I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG Grant O NO: O 164100510021 B-AWARD Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Talents I-ORG Support I-ORG Plan I-ORG of I-ORG Henan I-ORG Province I-ORG Colleges I-ORG and I-ORG Universities I-ORG Grant O NO: O 14HASTIT035 B-AWARD High-level B-ORG Personnel I-ORG Special I-ORG Support I-ORG Project I-ORG of I-ORG Zhengzhou I-ORG University I-ORG Grant O NO: O ZDGD13001 B-AWARD The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81773162 B-AWARD National O Natural O Science O Foundation O of O China O 81572901 B-AWARD National O Natural O Science O Foundation O of O China O 31170151 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O China O 2017A030313866 B-AWARD Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province O China O 2014A020209024 B-AWARD Science O and O Technology O Planning O Project O of O Guangdong O Province O China2014B020212017 O This O work O was O supported O by O the O Ministry B-ORG of I-ORG Land I-ORG and I-ORG Resources I-ORG of I-ORG China I-ORG Project O 201511054 B-AWARD the O National B-ORG Geographic I-ORG Society I-ORG Committee I-ORG for I-ORG Research I-ORG and I-ORG Exploration I-ORG No. O 8669-09 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Projects O 40920124002 B-AWARD and I-AWARD 41372016 O and O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Palaeobiology I-ORG and I-ORG Stratigraphy I-ORG Nanjing I-ORG Institute I-ORG of I-ORG Geology I-ORG and I-ORG Palaeontology I-ORG CAS I-ORG Project O 123102 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O ITC O Korea O KRA O Project O was O supported O by O grants O from O the O Republic O of O Korea O National O Health O Promotion O Fund O the O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG FDN-148477 O and O the O US B-ORG National I-ORG Cancer I-ORG Institute I-ORG P01 O CA200512 O Additional O support O to O G.T.F O is O provided O by O a O Senior O Investigator O Grant O from O the O Ontario B-ORG Institute I-ORG for I-ORG Cancer I-ORG Research I-ORG IA-004 O This O work O was O supported O in O part O by O the O Social B-ORG Sciences I-ORG and I-ORG Humanities I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG under O Grant O 18YJC88002 B-AWARD in O part O by O the O Guangdong B-ORG Provincial I-ORG Key I-ORG Platform I-ORG and I-ORG Major I-ORG Scientific I-ORG Research I-ORG Projects I-ORG Featured I-ORG Innovation I-ORG Projects I-ORG under O Grant O 2017GXJK136 B-AWARD and O in O part O by O the O Guangzhou B-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Education I-ORG Project I-ORG under O Grant O 201709P14 B-AWARD This O study O was O supported O by O the B-ORG Medical I-ORG and I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. O 2018RC079 B-AWARD to O S. O W O the B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. O 2017C37147 B-AWARD to O S. O W O the B-ORG Science I-ORG and I-ORG Technology I-ORG Key I-ORG Project I-ORG of I-ORG Jinhua I-ORG City I-ORG No. O 20163011 B-AWARD to O S. O W O and O the B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Jinhua I-ORG City I-ORG No. O 20164024 B-AWARD to O Y. O P.) O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81600039 B-AWARD 91739109 B-AWARD 81700054 B-AWARD 81570046 B-AWARD and O 31571199 B-AWARD Shenzhen B-ORG Municipal I-ORG Basic I-ORG Research I-ORG Program I-ORG JCYJ20170818144127727 O and O CXZZ20130515092016300 B-AWARD Shenzhen B-ORG University I-ORG start-up I-ORG funding I-ORG 2018043 O and O Shenzhen B-ORG University I-ORG Interdisciplinary I-ORG Innovation I-ORG Team I-ORG Project I-ORG 000003 O This O work O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos.11647140 O 61602316 B-AWARD 61872152 B-AWARD 61502179 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG of O China O Grant O Nos O 2018A030310147 B-AWARD 2016A030310027 B-AWARD 2014A030310265 B-AWARD Guangdong O Program O for O Special O Support O of O Top-notch O Young O Professionals O No. O 2015TQ01X796 B-AWARD Pearl B-ORG River I-ORG Nova I-ORG Program I-ORG of I-ORG Guangzhou I-ORG No. O 201610010037 B-AWARD the O Science O and O Technology O Innovation O Projects O of O Shenzhen O No. O JCYJ20170818140234295 B-AWARD and O the O CICAEET O fund O and O the O PAPD O fund O No. O KJR1615 B-AWARD Mohsen O Razavi O acknowledges O the O support O of O UK B-ORG EPSRC I-ORG Grant I-ORG EP/M013472/1 B-AWARD Cai O Zhang O is O sponsored O by O the O State O Scholarship O Fund O of O the O China O Scholarship O Council O All O data O generated O in O this O paper O can O be O reproduced O by O the O provided O methodology O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 81971793 B-AWARD 81772023 B-AWARD the O Shenyang B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Support I-ORG Plan I-ORG for I-ORG Young I-ORG and I-ORG Middle-aged I-ORG Talent I-ORG grant O number O RC200412 B-AWARD and O The O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province I-ORG 2022-YGJC-74 O This O study O was O supported O by O National B-ORG Key I-ORG R&D I-ORG Projects I-ORG 2017YFD0500605 O 2017YFD0501102 B-AWARD Key B-ORG R&D I-ORG Project I-ORG in I-ORG Shaanxi I-ORG Province I-ORG of I-ORG China I-ORG 2019NY-076 O and O The B-ORG Youth I-ORG Innovation I-ORG Team I-ORG of I-ORG Shaanxi I-ORG Universities I-ORG Grant O number O 1). O The O Newcastle O 85+ O Study O has O been O funded O by O the O Medical B-ORG Research I-ORG Council I-ORG G0500997 O G0601333 B-AWARD MR/J50001X/1 B-AWARD Biotechnology O and O Biological O Sciences O Research O Council O the O Dunhill B-ORG Medical I-ORG Trust I-ORG R124/0509 O and O the O National B-ORG Institute I-ORG of I-ORG Health I-ORG Research I-ORG School I-ORG for I-ORG Primary I-ORG Care I-ORG NIHR O SPCR I-AWARD 303 O LR O is O supported O by O a O NIHR O Senior O Investigator O award O Parts O of O the O work O have O also O been O funded O by O the O British B-ORG Heart I-ORG Foundation I-ORG PG/08/026/24712 O Unilever B-ORG Corporate I-ORG Research I-ORG CH-2008-1200 O Newcastle B-ORG University I-ORG Newcastle I-ORG Healthcare I-ORG Charity I-ORG CM/GW O 25/9/06 O and O the O North O of O England O Commissioning O Support O Unit O The O views O expressed O are O those O of O the O author(s O and O not O necessarily O those O of O the O NIHR O the O National O Health O Service O or O the O Department O of O Health O This O project O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China O grant O numbers O 2016YFB0301201 B-AWARD and O 2016YFB0300603 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 51504060 B-AWARD The O PhD O Start-up O Foundation O of O Science O Project O of O Liaoning O Province O grant O number O 201501150 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities O grant O number O N160713001 B-AWARD and O National O Training O Program O of O Innovation O and O Entrepreneurship O for O Undergraduates O No. O 201910145096 O This O work O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grants I-ORG No. O 81670757 B-AWARD 81570742 B-AWARD the B-ORG development I-ORG of I-ORG science I-ORG and I-ORG technology I-ORG of I-ORG Shandong I-ORG Province I-ORG No. O 2010GSF10228 B-AWARD 2012GGH11862 B-AWARD 2014GSF118118 B-AWARD Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grants I-ORG No. O ZR2016HQ26 B-AWARD Y2008C73 B-AWARD ZR2010HM044 B-AWARD Shandong B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Program I-ORG China I-ORG No. O 2009GGB14001 B-AWARD Excellent B-ORG Young I-ORG and I-ORG Middle-aged I-ORG Scientists I-ORG of I-ORG Shandong I-ORG Province I-ORG No. O 2004BS02016 B-AWARD and O the B-ORG development I-ORG of I-ORG science I-ORG and I-ORG technology I-ORG of I-ORG JiNan I-ORG City I-ORG No. O 201602172 B-AWARD The O study O was O funded O by O Award O from O Shanghai B-ORG Municipal I-ORG Health I-ORG Bureau I-ORG Grant O No. O 15GWZK0402 B-AWARD for O the O publication O fee O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81402693 B-AWARD and O Shanghai B-ORG Pujiang I-ORG Program I-ORG Grant O No. O 14PJC012 B-AWARD supported O the O study O design O data O collection O and O analysis O Shanghai O Municipal O People’s O Government O Decision-making O Consultation O Research O Project O Education O Policy O Special O Grant O No. O 2018-Z-R12 O supported O the O writing O and O editing O of O this O manuscript O We O thank O all O participants O in O the O MM O study O This O work O was O upported O by O grants O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grants I-ORG 81172857 O 81373188 O the B-ORG Chinese I-ORG National I-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Grants O 2011AA02A113 O the B-ORG National I-ORG Science I-ORG Technology I-ORG Pillar I-ORG Program I-ORG in I-ORG the I-ORG 12th I-ORG 5-year I-ORG Plan I-ORG 2014BAI07B00 O and O the B-ORG Capital I-ORG Health I-ORG Research I-ORG and I-ORG Development I-ORG of I-ORG Special I-ORG 2014-1-4011 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51908255 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20180301 O and O Jiangsu B-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Fund I-ORG CX(19)3092 O This O study O was O supported O by O Special B-ORG Fund I-ORG for I-ORG Agro-scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG 201303016 O and O National B-ORG 973 I-ORG Plan I-ORG Project I-ORG 2013CB127701 O by O the O fund O of O the O Modern B-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG CARS-3 O and O by O Hubei B-ORG Province I-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Center I-ORG 2011-620-003-03 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 32102608 B-AWARD to O Y.W O and O 31972625 B-AWARD to O S.X O the O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O to O S.X O Jiangsu B-ORG Planned I-ORG Projects I-ORG for I-ORG Postdoctoral I-ORG Research I-ORG Funds I-ORG 2021K321C O to O Y.W O and O the O Nantong B-ORG science I-ORG and I-ORG technology I-ORG project I-ORG JC2021010 O to O Y.W O This O work O was O supported O by O the O Hainan B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Project I-ORG No. O 319QN163 B-AWARD the O Fund B-ORG Project I-ORG of I-ORG Key I-ORG Laboratory I-ORG of I-ORG Integrated I-ORG Pest I-ORG Management I-ORG on I-ORG Crops I-ORG in I-ORG South I-ORG China I-ORG Ministry I-ORG of I-ORG Agriculture I-ORG P. I-ORG R. I-ORG China I-ORG No. O SCIPM2018-04 B-AWARD and O the O Research B-ORG Initiation I-ORG Project I-ORG of I-ORG Hainan I-ORG University I-ORG No. O KYQD[ZR]1823 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O project O “Institute O for O Research O and O Innovation O in O Health O Sciences“ O POCI-01-0145-FEDER-007274 O financed O by O FEDER—Fundo B-ORG Europeu I-ORG de I-ORG Desenvolvimento I-ORG Regional O funds O through O the O COMPETE O 2020—Operational O Programme O for O Competitiveness O and O Internationalisation O POCI O Portugal O 2020 O by O Portuguese O funds O through O FCT/MCTES O The O first O author O T.P.R O gratefully O acknowledges O FCT—Fundação B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG a I-ORG Tecnologia O Portugal O for O financial O support O Ph.D O grant O 2021.07672.BD B-AWARD The O last O author O M.S.L O gratefully O acknowledges O FCT B-ORG Portugal O for O financial O support O norma O transitória O do O DL B-AWARD n.º I-AWARD 57/2016 O This O research O was O funded O by O the O National B-ORG Key I-ORG R I-ORG I-ORG D I-ORG Program I-ORG of I-ORG China I-ORG no. O 2022YFC3500703 B-AWARD 2019YFC1709001 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 82174512 B-AWARD 81873383 B-AWARD the O Innovation B-ORG Team I-ORG and I-ORG Talents I-ORG Cultivation I-ORG Program I-ORG of I-ORG National I-ORG Administration I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG no. O ZYYCXTD-D-202003 B-AWARD and O the O Fund B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Sichuan I-ORG Province I-ORG China I-ORG no. O 2021ZYD0081 B-AWARD 2022ZDZX0033 B-AWARD This O work O was O supported O by O AMED B-ORG under O Grant O Number O JP17dk0110024 B-AWARD Grant-in-Aid B-ORG for I-ORG Scientific I-ORG Research I-ORG C) I-ORG KAKENHI I-ORG Grant O Number O 26460899 B-AWARD and O Grant-in-Aid B-ORG for I-ORG Young I-ORG Scientists I-ORG B) O Grant O Number O 17K15903 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 81601651 B-AWARD and I-AWARD 81625013 O the O Science B-ORG and I-ORG Technology I-ORG Committee I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG grant O numbers O 16dz1205500 B-AWARD 16DZ2290900 I-AWARD and I-AWARD 17DZ2273200 O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG grant O number O 2016YFC0800703 B-AWARD the O Ministry B-ORG of I-ORG Finance I-ORG of I-ORG China I-ORG grant O number O GY2016D1 B-AWARD This O work O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81870982 O 81571182 I-AWARD I-AWARD 81371354 O the O Program O for O Changjiang O Scholars O and O Innovative O Research O Team O in O University O IRT-16R37 O Research O Grant O of O Guangdong O Province O Key O Laboratory O of O Psychiatric O Disorders O N2019040 O National O Key O Basic O Research O Program O of O China O 2014CB542202 O the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2015A020212024 O Key O Research O O Development O Program O of O Guangzhou O Regenerative O Medicine O and O Health O Guangdong O Laboratory O 2018GZR110104008 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017A030312009 O This O work O was O supported O by O the O National O Natural O Science O Foundation O CN) O grant O no. O 1308017 O the O Jiangsu B-ORG social I-ORG science I-ORG fund I-ORG grant O no. O 15SHC006 B-AWARD to O YYL O the B-ORG 12th I-ORG Five I-ORG Year I-ORG Plan I-ORG of I-ORG Jiangsu I-ORG Education I-ORG grant O no. O B-a/2015/01/001 B-AWARD to O YYL O and O the O Open B-ORG Project I-ORG Program I-ORG of I-ORG Key I-ORG Laboratory I-ORG of I-ORG Child I-ORG Development I-ORG and I-ORG Learning I-ORG Science I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG Southeast I-ORG University I-ORG grant O no. O CDLS-2016-02 B-AWARD to O YYL O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Numbers O 61525305 B-AWARD and O 61625304 B-AWARD the O Shanghai B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O Numbers O 17ZR1409700 B-AWARD and O 18ZR1415300 B-AWARD the O basic B-ORG research I-ORG project I-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG Grant O Number O 16JC1400900 B-AWARD and O the O Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O Number O ZR2017BF021 B-AWARD This O research O was O supported O by O grants O from O the O Deutsche B-ORG Forschungsgemeinschaft I-ORG B.A O AN321/2-1 B-AWARD C.S O SCHW577/8-1 B-AWARD Further O support O was O provided O by O the O Hertie O Foundation O U.R O was O supported O by O grants O from O the O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health I-ORG R03MH094834 O and O from O the O National B-ORG Institute I-ORG on I-ORG Drug I-ORG Abuse I-ORG R03DA033491 O National O Institutes O of O Health O This O work O was O financially O supported O by O a O grant O from O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2012CB725202 O a O grant O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31370085 O a O grant O from O National O Undergraduate O Training O Program O for O Innovation O and O Entrepreneurship O 201610422074 O and O Shandong B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Plan I-ORG 2015GSF121042 O This O research O was O funded O by O grants O from O the O Utah B-ORG Science I-ORG Technology I-ORG and I-ORG Research I-ORG A34637 O and O A36815 B-AWARD and O by O a O grant O from O the O American O Board O of O Obstetrics O and O Gynecology O the O American O College O of O Obstetricians O and O Gynecologists O the O American B-ORG Society I-ORG for I-ORG Reproductive I-ORG Medicine O and O the O Society O for O Reproductive O Endocrinology O and O Infertility O 200784-00001 O This O work O was O also O supported O by O the O Utah B-ORG Agricultural I-ORG Experiment I-ORG Station I-ORG UTAO-1345 O and O approved O as O journal O paper O number O UAES O 9128 O This O work O was O supported O by O Special B-ORG Funds I-ORG for I-ORG Discipline I-ORG Construction I-ORG project O GAU-XKJS-2018-147 B-AWARD Research B-ORG Program I-ORG Sponsored I-ORG by I-ORG Gansu I-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Aridland I-ORG Crop I-ORG Science I-ORG Gansu I-ORG Agricultural I-ORG University I-ORG project O GSCS-2017-1 B-AWARD Scientific B-ORG Research I-ORG Start-up I-ORG Funds I-ORG for I-ORG Openly-recruited I-ORG Doctors I-ORG project O 2017RCZX-07 B-AWARD National O Natural O Science O Foundation O of O China O project O 31860526 O Gansu O Provincial O Science O Fund O for O Distinguished O Young O Scholars O project O 18JR3RA161 O International B-ORG Scientific I-ORG and I-ORG Technological I-ORG Cooperation I-ORG of I-ORG Gansu I-ORG Province I-ORG project O 1604WKCA010 B-AWARD and O Hall B-ORG of I-ORG Gansu I-ORG Province I-ORG Farming I-ORG Herd I-ORG Biology I-ORG Technology I-ORG project O GNSW-2013-19 B-AWARD The O above O funding O to O SZ O and O BX O was O used O for O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O in O writing O the O manuscript O This O work O is O supported O by: O 1. O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O Grant O No. O 61602002,https://isisn.nsfc.gov.cn B-AWARD Q.Y O 2. O the O AnHui B-ORG University I-ORG Youth I-ORG Skeleton I-ORG Teacher I-ORG Project O No. O E12333010289,http://www1.ahu.edu.cn/rsc/main/index.asp B-AWARD Q.Y O 3. O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation O No. O 2015M582826,http://jj.chinapostdoctor.org.cn/V1/Program3/Default.aspx B-AWARD L.X O 4. O Anhui B-ORG University I-ORG Doctoral I-ORG Scientific I-ORG Research I-ORG Start-up I-ORG Funding O J10113190084 B-AWARD Q.Y O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O Sino-Sweden B-ORG Joint I-ORG Research I-ORG Programme I-ORG 81861138006 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Numbers O 81973131 B-AWARD 81803319 B-AWARD 81903395 B-AWARD 81502056 B-AWARD the B-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangzhou I-ORG China I-ORG 201804020094 O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC1302704 O National B-ORG Science I-ORG Fund I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG of I-ORG China I-ORG 81325018 O the B-ORG Key I-ORG Project I-ORG for I-ORG International I-ORG Cooperation I-ORG and I-ORG Exchange I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81220108022 O Health B-ORG I-ORG Medical I-ORG Collaborative I-ORG Innovation I-ORG Project I-ORG of I-ORG Guangzhou I-ORG City I-ORG China I-ORG 201604020003 O This O work O was O supported O by O the O Earmarked O Fund O for O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-45 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG project O 31 I-AWARD 502 I-AWARD 140 O and O the O Fundamental O Research O Funds O for O the O Central B-ORG Universities I-ORG 2662015PY119 O H.Z O is O supported O by O the O China B-ORG Scholarship I-ORG Council O which O supports O her O study O at O McGill O University O CSC O 201 I-AWARD 706 I-AWARD 760 I-AWARD 039 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41673081 O 41373074 B-AWARD 41877346 B-AWARD and O 31500409 B-AWARD and O Zhejiang B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG 2013C33001 O This O work O was O supported O in O part O by O the O U.S B-ORG Department I-ORG of I-ORG Energy I-ORG under O Contract O DE-AC02-06CH11357 B-AWARD This O study O was O jointly O funded O by O the O Key B-ORG Project I-ORG of I-ORG Regional I-ORG Innovation I-ORG and I-ORG Development I-ORG Joint I-ORG Fund I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U20A2056 O Special B-ORG Funds I-ORG for I-ORG Construction I-ORG of I-ORG Innovative I-ORG Provinces I-ORG in I-ORG Hunan I-ORG Province I-ORG 2019RS3022 O and O the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG of I-ORG MOF I-ORG and I-ORG MARA I-ORG CARS-35 O This O work O was O supported O by O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Taiwan O R.O.C O MOST105‐2320‐B‐039‐031 O China B-ORG Medical I-ORG University I-ORG Hospital O Taichung O Taiwan O DMR‐105‐050 O in O part O by O Taiwan O Ministry B-ORG of I-ORG Health I-ORG and I-ORG Welfare I-ORG Clinical O Trial O and O Research O Center O of O Excellence O MOHW105‐TDU‐B‐212‐133019 O and O “The O Aim O for O The O Top O University O Plan” O from O Traditional O Chinese O Medicine O Research O Center O of O China O Medical O University O Taichung O Taiwan O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O No O additional O external O funding O received O for O this O study O JGD O was O funded O by O a O Wenner-Gren B-ORG Foundation I-ORG Dissertation O Fieldwork O Grant O entitled O ‘House O Architecture O and O Community O Organization O Exploring O Alternative O Pathways O to O Complexity O in O the O Southern O Brazilian O Highlands’ O Gr. O 9042 B-AWARD http://www.wennergren.org/grantees/gregorio-de-souza-jonas O This O paper O was O developed O in O the O context O of O project O ‘Jê O Landscapes O of O southern O Brazil O Ecology O History O and O Power O in O a O Transitional O Landscape O during O the O Late O Holocene’ O funded O by O the O Arts B-ORG and I-ORG Humanities I-ORG Research I-ORG Council I-ORG AH/K004212/1 O and O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo I-ORG 12/51328-3)(http://gtr.rcuk.ac.uk/projects?ref=AH/K004212/1 O granted O to O JI, O FM O and O PD. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O a O grant O from O the O Australian B-ORG Research I-ORG Council I-ORG ARC I-ORG Centre I-ORG of I-ORG Excellence I-ORG for I-ORG Innovations I-ORG in I-ORG Peptide I-ORG and I-ORG Protein I-ORG Science I-ORG CE200100012 O D. O J. O Craik O is O a O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG Australia I-ORG Leadership I-ORG Fellow I-ORG GNT O 2009564 O L. O Y. O Chan O was O supported O by O the B-ORG Advance I-ORG Queensland I-ORG Women’s I-ORG Academic I-ORG Fund I-ORG WAF-6884942288 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81400199 B-AWARD and O 81600218 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O BK20150321 B-AWARD and O BK20150320 B-AWARD Suzhou B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Foundation I-ORG No. O SYS201414 B-AWARD SYS201540 B-AWARD and O SYS201675 B-AWARD and O Natural B-ORG Science I-ORG Foundation I-ORG for I-ORG Colleges I-ORG and I-ORG Universities I-ORG in I-ORG Jiangsu I-ORG Province I-ORG No. O 15KJB180017 B-AWARD The O project O is O partially O supported O by O the O Shaanxi B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. B-AWARD 2017ZDXM-GY-009 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. B-AWARD 2017M613136 O Shaanxi B-ORG Provincial I-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. B-AWARD 2017BSHYDZZ13 O the O Fundamental O Research O Funds O for O the O Central O Universities O No. O xzy022019068 O The O project O is O funded O by O China B-ORG Medical I-ORG Board I-ORG CMB O 11-067 B-AWARD Shanghai B-ORG Public I-ORG Health I-ORG Key I-ORG Discipline I-ORG Construction I-ORG Project-Health I-ORG Economics I-ORG No O 12GWZX0601 B-AWARD Shanghai B-ORG Public I-ORG Health I-ORG Senior I-ORG Professional I-ORG Oversea I-ORG Fellowship I-ORG GWHW2012S10 O and O Shanghai B-ORG Public I-ORG Health I-ORG Excellent I-ORG Discipline I-ORG Leadership I-ORG Program I-ORG GWDTR201205 O to O YC. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O research O grants O from O Generalitat O de O Catalunya O Institut B-ORG Català I-ORG de I-ORG les I-ORG Dones I-ORG U-34/10)http://www20.gencat.cat/portal/site/icdones O and O Agència B-ORG de I-ORG Gestió I-ORG d’Ajuts I-ORG Universitaris I-ORG i I-ORG de I-ORG Recerca I-ORG AGUAR O VCP/3346/2009)http://agaur.gencat.cat/es/inici O and O Consejo B-ORG Superior I-ORG de I-ORG Deportes I-ORG 001/UPB10/11)http://www.csd.gob.es O Marta O Carrasco-Marginet O was O a O pre-doctoral O researcher O also O supported O by O AGAUR O VCP/3346/2009 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Scientific B-ORG Research I-ORG Project I-ORG of I-ORG Liaoning I-ORG Education I-ORG Department I-ORG LSNZD201905 O the O Key B-ORG Project I-ORG of I-ORG Liaoning I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 20170540801 B-AWARD the O 13th B-ORG 5-year I-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG Project I-ORG No. O 2017YFD0600600 B-AWARD and O the O Liaoning B-ORG Province I-ORG College I-ORG Students I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Training I-ORG Program I-ORG 2021-114 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O in O part O by O the B-ORG Guangxi I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Projects I-ORG KY2015LX056 O the B-ORG Self-Raised I-ORG Scientific I-ORG Research I-ORG Fund I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Health I-ORG of I-ORG Guangxi I-ORG Province I-ORG Z2016512 O Z2015621 I-AWARD GZZC15-34 I-AWARD Z2014241 O the B-ORG Innovation I-ORG Project I-ORG of I-ORG Guangxi I-ORG Graduate I-ORG Education I-ORG YCBZ2015030 O Guangxi B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Projects I-ORG 14124003-4 O the B-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Special I-ORG Project I-ORG 2012ZX10002010001009 O the O Traditional O Chinese O Medicine O Science O and O Technology O projects O of O the O Ministry O of O Health O of O Guangxi O Province O GZLC16-36 O and O the O Guangxi O Medical O Care O Appropriate O Technology O Research O and O Development O S201417-03 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81870027 O 81670023 B-AWARD and O 81570023 B-AWARD the B-ORG National I-ORG Key I-ORG Development I-ORG Plan I-ORG for I-ORG Precision I-ORG Medicine I-ORG Research I-ORG 2017YFC091004 O Science B-ORG and I-ORG Technology I-ORG Foundation I-ORG of I-ORG Sichuan I-ORG Province I-ORG No. O 2017SZ1031 O and O the O Program B-ORG for I-ORG New I-ORG Century I-ORG Excellent I-ORG Talents I-ORG in I-ORG University I-ORG No. O NCET-12-0380 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 52204397 B-AWARD the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Shanxi I-ORG Province I-ORG Grant O No. O 20210302123103 B-AWARD the B-ORG Major I-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Shanxi I-ORG Province I-ORG Grant O No. O 20181102016 B-AWARD and O the B-ORG China I-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2021M702544 B-AWARD This O work O was O financially O supported O by O the O Cooperation B-ORG Project I-ORG between I-ORG Universities I-ORG and I-ORG Institutes I-ORG Affiliated I-ORG with I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG in I-ORG Chongqing I-ORG HZ2021013 O the O Double B-ORG Thousand I-ORG Plan I-ORG of I-ORG Jiangxi I-ORG Province I-ORG JXSQ2020105012 O and O the O National B-ORG Key I-ORG Special I-ORG Sub I-ORG Project I-ORG of I-ORG China I-ORG 2019YFC1907702 O Section O 2.1“Genetically O encoded O reporters O for O oxygen O detection” O was O supported O by O the O Russian B-ORG Science I-ORG Foundation I-ORG RSF O Grant O 17-15-01175 B-AWARD to O D.S.B.);Section O 2.2“Genetically O encoded O reporters O of O redox O and O metabolic O parameters” O was O supported O by O the O Russian B-ORG Foundation I-ORG for I-ORG Basic I-ORG Research I-ORG RFBR O Grant O 18-54-74003 B-AWARD to O V.V.B.);Section O 3“In O vitro O models O for O real-time O imaging O of O cell O signaling O and O metabolism O during O the O course O of O hypoxia” O was O supported O by O Russian O Foundation O for O Basic O Research O project O No. O 19-29-04016 B-AWARD to O O.V.P.);Section O 4“Animal O models O for O real-time O imaging O of O cell O signaling O and O metabolism O during O the O course O of O hypoxia” O was O supported O by O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Higher I-ORG Education I-ORG of I-ORG the I-ORG Russian I-ORG Federation O project O No. O 075-15-2019-1789 B-AWARD to O Center O for O Precision O Genome O Editing O and O Genetic O Technologies O for O Biomedicine O Pirogov O Russian O National O Research O Medical O University O This O research O work O was O financially O supported O by O grants O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 91439125 B-AWARD 81570213 B-AWARD 81100101 B-AWARD 81570329 B-AWARD 81770229 B-AWARD the B-ORG Guangdong I-ORG Province I-ORG Natural I-ORG Science I-ORG Fund I-ORG No. O 2016A030313263 B-AWARD Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2015B010131010 B-AWARD Science B-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG Nos O 201707010206 B-AWARD 2014Y2-00118 B-AWARD and O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Jiangxi I-ORG Province I-ORG No. O 20171BAB215003 B-AWARD This O work O was O supported O by O the O Program O for O Science B-ORG Technology I-ORG Innovation I-ORG teams I-ORG in I-ORG Universities I-ORG of I-ORG Henan I-ORG Province I-ORG #181RTSTHN026 O the B-ORG innovation I-ORG team I-ORG of I-ORG Henan I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG #2015XTD003 O and O Henan B-ORG province’s I-ORG Key I-ORG Project I-ORG of I-ORG tackle I-ORG key I-ORG problems I-ORG of I-ORG science I-ORG and I-ORG technology I-ORG #172102310693 O The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O has O received O funding O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81371516 O Foundation B-ORG of I-ORG National I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG China I-ORG W201306 O Social B-ORG Development I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BE2015605 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20150109 O Research B-ORG Project I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Q201508 O Six B-ORG Talent I-ORG Peaks I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG 2015-WSN-079 O and O Key B-ORG Project I-ORG supported I-ORG by I-ORG Medical I-ORG Science I-ORG and I-ORG technology I-ORG development I-ORG Foundation I-ORG Nanjing I-ORG Department I-ORG of I-ORG Health I-ORG YKK15067 O The O strain O and O enzyme O acquisition O preliminary O experiments O and O data O analysis O were O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG Grant O Number O 2019CFB378 B-AWARD and O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG the I-ORG People’s I-ORG Republic I-ORG of I-ORG China I-ORG Grant O Number O 2016YFD0501209 B-AWARD The O experiment O performance O data O collection O analysis O and O interpretation O of O data O were O supported O by O the O Chinese B-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG Grant O Number O CAAS-ASTIP-2016-OCRI B-AWARD This O study O was O sponsored O by O Sino-German B-ORG Center I-ORG for I-ORG Research I-ORG Promotion I-ORG GZ1357 O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0900305 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 42076106 O and O 41576158 B-AWARD This O study O was O financed O by O the O Scientific I-ORG Research I-ORG Foundation I-ORG for I-ORG the I-ORG Returned I-ORG Overseas I-ORG Chinese I-ORG Scholars I-ORG Sun I-ORG Yat-sen I-ORG University I-ORG Cancer I-ORG Center I-ORG 05010201 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81602137 O and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 17ykzd31 O This O research O was O funded O by O the B-ORG General I-ORG Research I-ORG Project I-ORG of I-ORG the I-ORG Zhejiang I-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG grant O number O Y202249114 B-AWARD the B-ORG Projects I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 72074053 B-AWARD the B-ORG Top I-ORG Tourism I-ORG Talent I-ORG Cultivation I-ORG Program I-ORG in I-ORG 2019 I-ORG by I-ORG Zhejiang I-ORG Provincial I-ORG Department I-ORG of I-ORG Culture I-ORG and I-ORG Tourism I-ORG grant O number O 2019LYBJ0103 B-AWARD and B-ORG the I-ORG Youth I-ORG Key I-ORG Project I-ORG of I-ORG Premier I-ORG Humanities I-ORG and I-ORG Social I-ORG Science I-ORG Program I-ORG for I-ORG Higher I-ORG Educational I-ORG Institutes I-ORG of I-ORG Zhejiang I-ORG Province I-ORG China I-ORG grant O number O 2018QN015 B-AWARD This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81600126 O 31671722 O the O National O Key O R&D O Program O of O China O 2016YFD0400505 O Tianjin B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG 17PTGCCX00190 O Rural O Affairs O Committee O of O Tianjin O 201701180 O the O Innovative O Research O Team O of O Tianjin B-ORG Municipal I-ORG Education I-ORG Commission I-ORG TD13-5013 O and O Tianjin O Municipal O Education O Commission O 2017KJ009 O The O current O study O was O supported O by O Central B-ORG University I-ORG Basic I-ORG Research I-ORG Funds I-ORG Project I-ORG of I-ORG China I-ORG 2452016057 O 2452015171 O Inaugurating B-ORG Program I-ORG of I-ORG Northwest I-ORG A I-ORG I-ORG F I-ORG University I-ORG for I-ORG Doctoral I-ORG Staff I-ORG 2452015295 O Natural B-ORG Science I-ORG Basic I-ORG Research I-ORG Project I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 2018JQ3066 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31700332 O 31800510 B-AWARD Special B-ORG Financial I-ORG Grant I-ORG from I-ORG the I-ORG China I-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017T100782 O The O funding O agency O was O not O involved O in O the O design O of O the O study O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O financially O supported O by O Special O Fund O for O Agro-Scientific B-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG 201303028 O Science B-ORG and I-ORG Technology I-ORG Program I-ORG Public I-ORG Service I-ORG Technology I-ORG Application I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2017C32040 O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31500124 O and O Science B-ORG and I-ORG technology I-ORG fund I-ORG of I-ORG Putian I-ORG City I-ORG 2016S3001 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0500204 O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 7172155 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81772144 O and O the O Chinese B-ORG State I-ORG Key I-ORG Project I-ORG Specialized I-ORG for I-ORG Infectious I-ORG Diseases I-ORG 2018ZX10711001-003 O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0101303 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31770575 O 31470571 B-AWARD Programs B-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG of I-ORG Heilongjiang I-ORG Provice I-ORG China I-ORG GA19B103 O Graduate B-ORG Innovation I-ORG Fund I-ORG of I-ORG Harbin I-ORG Normal I-ORG University I-ORG HSDBSCX2016-4 O and O the O National B-ORG Major I-ORG Project I-ORG for I-ORG Cultivation I-ORG of I-ORG Transgenic I-ORG Crops I-ORG 2016ZX08004-002-003 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Special B-ORG Foundation I-ORG for I-ORG Scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG by I-ORG the I-ORG National I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG China I-ORG 201402001 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31471366 O PUMC B-ORG Youth I-ORG Fund I-ORG A107000 O and O Specialized B-ORG Research I-ORG Fund I-ORG for I-ORG the I-ORG Doctoral I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG of I-ORG China I-ORG 81150027 O This O research O was O funded O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2019YFD0900200 O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG of I-ORG MOF I-ORG and I-ORG MARA I-ORG CARS-47 O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG 2021A1515010428 O and O the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Zhanjiang I-ORG 2020A05003 O This O work O was O funded O under O grants O from O the O Royal B-ORG Society I-ORG CHG\R1\170017 O and O URF\R\180017 B-AWARD Engineering B-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG EPSRC O EP/M003701/1 O and O the O Medical B-ORG Research I-ORG Council I-ORG MRC O funded O SHIELD O consortium O MRNO2995X/1 O G.S.C O is O funded O under O ‘OPTIMA O The O EPSRC O and O MRC O Centre O for O Doctoral O Training O in O Optical O Medical O Imaging’ O B.R.P O holds O a O Royal O Society O University O Research O Fellowship O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81702195 B-AWARD the O Project O of O Application B-ORG Demonstration I-ORG Center I-ORG of I-ORG Precision I-ORG Medicine I-ORG for I-ORG Molecular I-ORG Diagnosis I-ORG in O Jilin O Province O 2016-2018 O NDRC O the O Department B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Jilin I-ORG Province I-ORG China I-ORG Grant O No. O 20180520125JH B-AWARD the O Project O of O Education B-ORG Department I-ORG of I-ORG Jilin I-ORG Province I-ORG China I-ORG Grant O No. O JJKH20170853KJ B-AWARD the O Project O of O Bethune B-ORG Youth I-ORG Foundation I-ORG of I-ORG Jilin I-ORG University I-ORG China I-ORG Grant O No. O 2015409 B-AWARD and O the O Project O of O Health B-ORG Management I-ORG Department I-ORG of I-ORG Jilin I-ORG Province I-ORG China I-ORG Grant O No. O 20132003 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No.71673121 O and O No.71373102 O the O Research B-ORG Innovation I-ORG Program I-ORG for I-ORG College I-ORG Graduates I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grant O No. O KYZZ_0288 B-AWARD and O Jiangsu B-ORG Government I-ORG Scholarship I-ORG for I-ORG Overseas I-ORG Studies I-ORG Grant O No. O JS-2016-099 B-AWARD The O funding O agencies O had O no O role O in O the O design O of O the O study O collection O analysis O interpretation O of O the O data O or O writing O the O manuscript O We O acknowledge O funding O from O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG www.nih.gov O EEID O award O 1 B-AWARD R01 I-AWARD GM105247-01 I-AWARD to O YT, O KS, O and O MF; O the O National B-ORG Science I-ORG Foundation O Ebola B-AWARD RAPID I-AWARD DMS-1514704 I-AWARD to O KS O and O MF; O and O the O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG www.bbsrc.ac.uk O BB/K010972/4 B-AWARD to O YT, O KS, O and O MF. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31671763 O and I-AWARD 31471567 O the O Science B-ORG Technology I-ORG Department I-ORG of I-ORG Zhejiang I-ORG Province I-ORG in I-ORG China I-ORG 2017C32077 O and O the O National B-ORG Key I-ORG Research I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0101404 O This O work O was O supported O by O MICINN B-ORG projects I-ORG RTI2018-097195-B-I00 O RTI2018-096918-B-C41 B-AWARD PID2021-122562NB-I00 B-AWARD and O PID2021-123190OB-I00/AEI/10.13039/501100011033/FEDER B-AWARD UE O The O authors O acknowledge O the O financial O support O of O the O excellence O research O network O RED2018-102609-T B-AWARD by O MINECO B-ORG The O authors O acknowledge O the O support O from O the O Air B-ORG Force I-ORG Office I-ORG of I-ORG Scientific I-ORG Research I-ORG under O Award O No. O FA8655-20-1-7013 B-AWARD Program O Manager O Ali O Sayir O M.A.-O O acknowledges O financial O support O from O MICINN O FPU O contract O No. O FPU15/01982 B-AWARD and O thanks O the O Central B-ORG Research I-ORG Development I-ORG Fund I-ORG CRDF I-ORG of I-ORG the I-ORG University I-ORG of I-ORG Bremen I-ORG for O funding O ZF04/2021 O J.S.M O and O J.J O were O supported O by O the O Air O Force O Office O of O Scientific O Research O under O award O number O FA9550–21–1–0507 B-AWARD monitored O by O Dr. O Ali O Sayir O Any O opinions O finding O and O conclusions O or O recommendations O expressed O in O this O material O are O those O of O the O author O and O do O not O necessarily O reflect O the O views O of O the O United O States O Air O Force O This O research O was O funded O by O the O Ministry B-ORG of I-ORG Trade I-ORG Industry I-ORG and I-ORG Energy I-ORG MOTIE O Grant O number O 10063540 B-AWARD and O the O Korea B-ORG Institute I-ORG of I-ORG Industrial I-ORG Technology I-ORG KITECH O grant O number O EO200005 B-AWARD In O addition O it O was O also O supported O by O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O grant O funded O by O the O Korean O government O MSIT O No. O 2017H1D8A2031138 B-AWARD This O work O was O supported O by O Advanced O Production O Technology O Development O Program O Ministry B-ORG of I-ORG Agriculture I-ORG Food I-ORG and I-ORG Rural I-ORG Affairs I-ORG 114048-03-3-CG000 O Republic O of O Korea O the O Basic O Science O Research O Program O through O the O National O Research O Foundation O of O Korea O NRF O funded O by O the O Ministry B-ORG of I-ORG Science I-ORG ICT I-ORG and I-ORG Future I-ORG Planning I-ORG MISP O 2016R1A2A1A05005078 O and O by O Ministry B-ORG of I-ORG Education I-ORG 2016R1A6A3A11930649 O and O the O Intelligent O Synthetic O Biology O Center O of O the O Global O Frontier O Project O funded O by O MISP O 20110031961 O Republic O of O Korea O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 82000426 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanxi I-ORG Province O China O grant O numbers O 201801D121222 B-AWARD and O 201801D121337 B-AWARD and O the O Supporting B-ORG funds I-ORG for I-ORG doctors I-ORG in I-ORG the I-ORG First I-ORG Hospital I-ORG of I-ORG Shanxi I-ORG Medical I-ORG University I-ORG grant O numbers O 09686 B-AWARD for O the O page O charges O This O study O is O supported O by O the O American B-ORG Heart I-ORG Association O USA O 16SDG26420078 O Heilongjiang B-ORG Natural I-ORG Science I-ORG Foundation O China O ZD2018018 O and O Innovation B-ORG Fund I-ORG of I-ORG Harbin I-ORG Medical I-ORG University O China O YTSKYCX2018-38HYD O This O study O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32060060 O 32260271 B-AWARD the O Youth B-ORG Science I-ORG and I-ORG Technology I-ORG Fund I-ORG Program I-ORG of I-ORG Gansu I-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG 21JR1RA231 O the O Young B-ORG Teachers’ I-ORG Scientific I-ORG Research I-ORG Ability I-ORG Improvement I-ORG Plan I-ORG of I-ORG Northwest I-ORG Normal I-ORG University I-ORG NWNU-LKQN2021-30 O The O work O was O supported O by O the O Engineering B-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG UK) O under O grants O nos O EP/I00999X/1 B-AWARD and O EP/M006298/1 B-AWARD by O the O EU B-ORG under O PP6 O NEST O Project O No. O 517133 B-AWARD BRACCIA O and O Horizon B-ORG 2020 I-ORG Grant O Agreement O 642563 B-AWARD COSMOS O and O by O Action B-ORG Medical I-ORG Research I-ORG grant O no. O GN1963 B-AWARD This O work O was O supported O by O the B-ORG Zhejiang I-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O LQ22E010004 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 52101218 B-AWARD the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Provincial I-ORG Universities I-ORG of I-ORG Zhejiang I-ORG Grant O No. O GK219909299001-009 B-AWARD and O the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2021YFA1600203 B-AWARD This O work O was O supported O by O grants O obtained O from O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG No. O 2015CB943203 B-AWARD National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81102820 B-AWARD 81272315 B-AWARD 81172882 B-AWARD and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG No. O ZR2016HM21 B-AWARD ZR2017BC030 B-AWARD Scientific B-ORG development I-ORG program I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG of I-ORG Shandong I-ORG Province I-ORG 2017-240 O The B-ORG Open I-ORG Project I-ORG of I-ORG Shandong I-ORG Collaborative I-ORG Innovation I-ORG Center I-ORG for I-ORG Antibody I-ORG Drugs I-ORG No. O CIC-AD1813 B-AWARD This O work O was O supported O by O the O PUMC B-ORG Youth I-ORG Fund I-ORG and I-ORG the I-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for O the O Central O Universities O grant O number O 2017310036 B-AWARD the O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG grant O number O 2016-I2M-1-018 B-AWARD and O 2017-I2M-3-021 B-AWARD and O the O Scientific B-ORG Research I-ORG Project I-ORG of I-ORG Sichuan I-ORG Medical I-ORG Association I-ORG grant O number O S17082 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O No. O 61171186 B-AWARD 61271345,www.nsfc.gov.cn O HL; O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities O HIT.NSRIF.2012047,www.moe.gov.cn B-AWARD HL; O European B-ORG Research I-ORG Council O No. O 338164,http://erc.europa.eu B-AWARD BS; O and O European O Union’s O Horizon O 2020 O research O and O innovation O program O 645378 O EC. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Italian B-ORG Ministry I-ORG of I-ORG Health I-ORG grant O IZS B-AWARD SA I-AWARD 06/21 I-AWARD RC O and O grant O IZS B-AWARD PLV I-AWARD 08/19 I-AWARD RC) O and O the O University B-ORG of I-ORG Sassari I-ORG Fondo O di O Ateneo O per O la O Ricerca O 2020 B-AWARD Tania O Carta’s O post-graduate O scholarship O is O funded O by O the O University O of O Sassari O S.P.G O is O funded O by O a O UKRI B-ORG Biotechnology I-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG BBSRC I-ORG Institute I-ORG Strategic I-ORG Programme I-ORG Grant O to O The O Pirbright O Institute O BBS/E/I/00007031 O This O work O has O been O supported O by O the O Ministry O of O Science O and O Higher O Education O of O the O Russian O Federation O Southern O Federal I-ORG University O 2022 O project O FENW-2023-0011 B-AWARD Fundamental B-ORG Scientific I-ORG Research I-ORG of I-ORG the I-ORG State I-ORG Academies I-ORG of I-ORG Sciences I-ORG for O 2022–2025 O grant O no. O 0710-2019-0044 B-AWARD and O the O Thailand B-ORG Science I-ORG Research I-ORG and I-ORG Innovation I-ORG Fund I-ORG Chulalongkorn I-ORG University I-ORG HEA662300073 O This O research O was O funded O by O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Taiwan I-ORG under O grant O numbers O MOST111-2311-B-110-001 B-AWARD and O MOST110-2314-B-037-117-MY2 B-AWARD the O NSYSU-KMU B-ORG Joint I-ORG Research I-ORG Project I-ORG #NSYSYKMU O 111-I06 O and O the O Chi-Mei B-ORG Medical I-ORG Center I-ORG and I-ORG Kaohsiung I-ORG Medical I-ORG University I-ORG Research I-ORG Foundation I-ORG Taiwan I-ORG grant O number O 109 B-AWARD CM-KMU-006 O This O study O was O supported O by O the B-ORG National I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 52108187 O Anhui B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2008085QE244 O Key B-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG Anhui I-ORG Province I-ORG 201904a07020081 O and O the B-ORG Doctoral I-ORG Foundation I-ORG of I-ORG Anhui I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 13846 O This O work O was O supported O by O a O Grant-in-Aid B-ORG for I-ORG Scientific I-ORG Research I-ORG JSPS O KAKENHI I-AWARD Grant I-AWARD Number I-AWARD JP15H04950 O a O Grant-in-Aid B-ORG for I-ORG Young I-ORG Scientists I-ORG B) I-ORG JSPS O KAKENHI I-AWARD Grant I-AWARD Number I-AWARD JP15K19972 O and O a O Grant-in-Aid B-ORG for I-ORG the I-ORG Strategic I-ORG Young I-ORG Researcher I-ORG Overseas I-ORG Visits I-ORG Program I-ORG for I-ORG Accelerating I-ORG Brain I-ORG Circulation I-ORG from I-ORG the I-ORG Japan I-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG JSPS O KAKENHI I-AWARD Grant I-AWARD Number I-AWARD JPS2407 O This O research O was O funded O by O the O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III I-ORG Ministerio I-ORG de I-ORG Economia I-ORG y I-ORG Competividad O grant O numbers O PI/17/0575 B-AWARD PI19/00374 B-AWARD PI B-AWARD 20/00531 I-AWARD and O PI22/00102 B-AWARD TRANSCAN B-ORG grant O numbers O AECC B-AWARD AC I-AWARD 18/000002 I-AWARD and O ISCIII B-AWARD and O Generalitat B-ORG de I-ORG Catalunya O grant O numbers O 2017 B-AWARD SGR288 I-AWARD GRC I-AWARD and O SGR00560 B-AWARD GRC I-AWARD This O study O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG 2016YFD0201131 O the O earmarked O fund O for O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31471845 O and O the O Modern B-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG of I-ORG China I-ORG CARS-27 O This O work O was O supported O by: O 1. O the O Wellcome B-ORG Trust O grant O numbers O 101896/Z/13/Z B-AWARD and O the O URLswww.wellcome.ac.uk O 2. O European B-ORG Research I-ORG Council I-ORG Advanced O Grant O 323113-NETSIGNAL O andhttps://erc.europa.eu/advanced-grants O 3. O the O Seventh B-ORG Framework I-ORG Programme I-ORG for O Research O and O Technological O Development O FP7 O ITN O 606950 O EXTRABRAIN O andhttps://ec.europa.eu/research/fp7/index_en.cfm O and O 4. O Russian B-ORG Science I-ORG Foundation I-ORG grant O 15-14-30000 O support O for O cluster O arrangements)http://rscf.ru/en O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61604078 O Natural B-ORG Science I-ORG Youth I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20160905 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG of I-ORG China I-ORG 16KJB510029 O and O NUPTSF B-ORG NY216010 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Young O Scholars O Program O 31701829 O National O Natural O Science O Foundation O of O China O 31672075 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Young O Scholars O Program O BK20170709 O National B-ORG Postdoctoral I-ORG Program I-ORG for I-ORG Innovative I-ORG Talents I-ORG BX201600074 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017M611839 O This O study O was O supported O by O a O grant O entitled O “2018 O Graduate O Program O of O Undiscovered O Taxa” O from O the O National B-ORG Institute I-ORG of I-ORG Biological I-ORG Resources I-ORG NIBR O funded O by O the O Ministry O of O Environment O MOE O of O the O Republic O of O Korea O NIBR201839201 O grants O NRF-2017K2A9A1A06051528 O NRF-2018R1D1A1B07050117 B-AWARD from O the O Korea B-ORG Research I-ORG Foundation O the O BK21 O Plus O Program O Eco-Bio O Fusion O Research O Team O 22A20130012352 B-AWARD funded O by O the O Ministry B-ORG of I-ORG Education I-ORG MOE O South O Korea O a O grant O R2020035 O from O the O National B-ORG Institute I-ORG of I-ORG Fisheries I-ORG Science I-ORG NIFS O of O the O Republic O of O Korea O and O a O grant O 18-504-51026 B-AWARD Russian B-ORG Fund I-ORG of I-ORG Basic I-ORG Research O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81803463 O 81700382 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2018A030310183 O 2019A1515012166 B-AWARD and O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG 907181975046 O and O Traditional B-ORG Chinese I-ORG Medicine I-ORG Program I-ORG of I-ORG Guangdong I-ORG 20201208 O This O work O was O supported O by O a O research O fund O from O the O International O Young O Scientists O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31750110469 B-AWARD China O the B-ORG Shaanxi I-ORG Introduced I-ORG Talent I-ORG Research I-ORG Funding O A279021901 O China O and O The O Introduction B-ORG of I-ORG Talent I-ORG Research I-ORG Start-up I-ORG Fund I-ORG Grant O No. O Z101021904 B-AWARD College O of O Natural O Resources O and O Environment O Northwest O A&F O University O Yangling O Shaanxi O Province O 712100 O China O The O Mobility B-ORG for I-ORG Regional I-ORG Excellence-2020 I-ORG Grant O No. I-AWARD RUN I-AWARD 2017-00771 O European O Union’s O Horizon O 2020 O Research O and O Innovation O Programme O under O the O Marie O Skłodowska-Curie O grant O agreement O No. O 754412 O at O University O of O Borås O Borås O Sweden O and O Guizhou B-ORG Science I-ORG and I-ORG Technology I-ORG Corporation I-ORG Platform I-ORG Talents I-ORG Fund I-ORG China I-ORG Grant O No O 2017]5733-001 B-AWARD I-AWARD CK-1130-002 O We O are O also O thankful O to O all O our O laboratory O colleagues O and O research O staff O members O for O their O constructive O advice O and O help O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41976178 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O Number O 2018YFC1406305 B-AWARD the O Wildlife O Conservation O Society O WCS O and O the O Western B-ORG Indian I-ORG Ocean I-ORG Marine I-ORG Science I-ORG Association I-ORG WIOMSA O for O funding O project O BYCAM O Grant O Number O MASMA/CP/2014/01 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of O China O No. O LQ21H180004 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81930111 B-AWARD Research B-ORG Project I-ORG on I-ORG Chinese I-ORG Medicine I-ORG Health I-ORG Services I-ORG No. O 2023ZF013 B-AWARD Research B-ORG Project I-ORG of I-ORG Zhejiang I-ORG Chinese I-ORG Medical I-ORG University I-ORG No. O 2022JKZKTS20 B-AWARD and O College B-ORG level I-ORG scientific I-ORG research I-ORG cultivation I-ORG project I-ORG of I-ORG Zhejiang I-ORG Chinese I-ORG Medical I-ORG University I-ORG No. O 2022TS002 B-AWARD This O work O was O supported O by O the O Austrian B-ORG Cancer I-ORG Aid/Tyrol I-ORG project O n. O 17003 B-AWARD to O F.F O by O the O Austrian B-ORG Science I-ORG Fund I-ORG FWF O project O n. O T B-AWARD 974-B30 I-AWARD to O F.F O and O by O the O European B-ORG Research I-ORG Council I-ORG advanced O grant O agreement O n. O 786295 B-AWARD to O Z.T O This O research O was O funded O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG grant O no. O 2018CDYJSY0055 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 11332013 B-AWARD 11802045 I-AWARD and I-AWARD 11802047 O National B-ORG Postdoctoral I-ORG Program I-ORG for I-ORG Innovative I-ORG Talents I-ORG Grant O No. O BX20190039 B-AWARD the O Postdoctoral B-ORG Program I-ORG for I-ORG Innovative I-ORG Talents I-ORG of I-ORG Chongqing I-ORG grant O no. O CQBX201804 B-AWARD and O the O China O Postdoctoral O Science O Foundation O funded O project O grant O no. O 2018M631058 B-AWARD This O study O has O received O funding O by O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG CIFMS O grant O number O 2016-I2M-1-001 B-AWARD PUMC B-ORG Youth I-ORG Fund I-ORG grant O number O 2017320010 B-AWARD and O Beijing B-ORG Hope I-ORG Run I-ORG Special I-ORG Fund I-ORG of I-ORG Cancer I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O LC2016B15 B-AWARD The O data O collection O on O which O this O study O is O based O was O supported O by O the O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health I-ORG NIMH O U01-MH57716 B-AWARD with O supplemental O support O from O the O Office O of O Behavioral O and O Social O Science O Research O at O the O National O Institutes O of O Health O NIH O and O the O University O of O Michigan O The O preparation O of O this O manuscript O was O supported O by O grants O from O the O National O Institute O of O Drug O Abuse O DA O 20826 O National B-ORG Institute I-ORG on I-ORG Minority I-ORG Health I-ORG and I-ORG Health I-ORG Disparities I-ORG MD O 00508 I-AWARD MD I-AWARD 006923 O National O Institute O of O Mental O Health O R01-MH082807 O and O from O the O National B-ORG Institute I-ORG on I-ORG Aging I-ORG P30-AG15281 O This O research O was O funded O by O Fundação B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG Tecnologia I-ORG FCT I-ORG Portugal O grant O number O UIDB/50006/2020 B-AWARD LAQV-REQUIMTE O UIDP/04378/2020 B-AWARD and O UIDB/04378/2020 B-AWARD UCIBIO O and O LA/P/0140/2020 B-AWARD i4HB O the O European B-ORG Commission I-ORG GLYCOTwinning I-ORG GA O 101079417 O the O EJPRD B-ORG ProDGNE I-ORG EJPRD/0001/2020 O EU I-AWARD 825575 O and O SI B-ORG I&DT I-ORG DCMatters I-ORG AVISO O Nº I-AWARD 17/SI/2019 O REF O 47212 O F.P O gratefully O acknowledges O FCT O for O an O Assistant O Research O Position O CEECIND/01649/2021 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 81641033 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG grant O no. O ZR2019MH017 B-AWARD and O the O Clinical B-ORG Medical I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Plan I-ORG of I-ORG Jinan I-ORG City I-ORG grant O no. O 201704089 B-AWARD And O the O funding O bodies O had O no O roles O in O the O study O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21676098 O 21808069 B-AWARD and O 21878103 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG of I-ORG China I-ORG 2018A030310368 O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Pulp I-ORG and I-ORG Paper I-ORG Engineering I-ORG 2017C03 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017M612667 O 2018T110871 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2017BQ084 O 2017PY013 B-AWARD This O research O was O supported O by O a O grant O from O the O Beijing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG Z171100000417042 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0908800 O and O the B-ORG “Beijing I-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospitals” I-ORG Ascent I-ORG Plan I-ORG DFL20150601 O The O funding O body O had O no O influence O on O design O of O the O study O data O collection O analysis O interpretation O of O data O and O in O writing O of O the O manuscript O Research O reported O in O this O publication O was O supported O by O the O National B-ORG Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute I-ORG NHLBI O of O the O National O Institutes O of O Health O under O Award O Number O R34HL135214 B-AWARD Additional O support O has O been O provided O by O the O Utah O Trial O Innovation O Center O funded O by O the O National B-ORG Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences I-ORG NCATS O under O cooperative O agreement O U24TR001597 B-AWARD The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O National O Institutes O of O Health O This O project O is O also O supported O in O part O by O the O Health O Resources O and O Services O Administration O HRSA O Maternal B-ORG and I-ORG Child I-ORG Health I-ORG Bureau I-ORG MCHB O Emergency O Medical O Services O for O Children O EMSC O Network O Development O Demonstration O Program O under O cooperative O agreements O U03MC00008 B-AWARD U03MC00001 B-AWARD U03MC00003 B-AWARD U03MC00006 B-AWARD U03MC00007 B-AWARD U03MC22684 B-AWARD and O U03MC22685 B-AWARD This O information O or O content O and O conclusions O are O those O of O the O author O and O should O not O be O construed O as O the O official O position O or O policy O of, O nor O should O any O endorsements O be O inferred O by O HRSA O Health O and O Human O Services O HHS O or O the O US O Government O The O funding O organizations O had O no O role O in O the O design O and O conduct O of O the O study O collection O management O analysis O and O interpretation O of O the O data O preparation O review O or O approval O of O the O manuscript O and O decision O to O submit O the O manuscript O for O publication O This O study O was O partially O supported O by O research O grants O from O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG NSC102-2314-B-006-079 O the O Ministry B-ORG of I-ORG Health I-ORG and I-ORG Welfare I-ORG MOHW106-TDU-B-211-113003 O Sin-Lau B-ORG Hospital I-ORG SLH-M106-01 O SLH-M107-02 B-AWARD and O SLH-M108-01 B-AWARD and O National B-ORG Cheng I-ORG Kung I-ORG University I-ORG Hospital I-ORG NCKUH-10704031 O Tainan O Taiwan O The O research O was O awarded O the O Jilin O Province O Science O and O Technology O Guidance O Program O Project O 20180312006ZG O Science O and O Technology O Research O Project O of O Jilin B-ORG Education I-ORG Department I-ORG JJKH20170308KJ O Jilin B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Project O 20190201168JC O Jilin B-ORG Province I-ORG Education I-ORG Department I-ORG Science O and O Technology O Research O Project O JJKH20180661KJ O Jilin O Province O Key O Technology O R&D O Project O 20180201029NY O Jilin O Province O Support O for O the O Science O and O Technology O Development O Program O 20190802012ZG O and O Jilin O Province O Science O and O Technology O Guidance O Project O 20180312006ZG O Grant O sponsor O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O numbers O 81901930 B-AWARD and O 81772111 B-AWARD Emergency B-ORG and I-ORG critical I-ORG care-important I-ORG weak I-ORG disciplines I-ORG of I-ORG the I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG Grant O number O 2016ZB0203 B-AWARD Shanghai B-ORG Shenkang I-ORG Project I-ORG Grant O number O SHDC12016126 B-AWARD Shanghai B-ORG Health I-ORG System I-ORG Talents I-ORG Training I-ORG Program I-ORG Grant O number O 2018BR13 B-AWARD This O work O was O supported O by O SAPIENZA B-ORG University I-ORG of I-ORG Rome I-ORG grant O n.MA116154CD981DAE O CS O Marie B-ORG Curie I-ORG Career I-ORG Reintegration I-ORG Grant I-ORG PCIG09-GA-2011-293589 B-AWARD VT) O and O the O Jerome B-ORG Lejeune I-ORG Foundation I-ORG Research I-ORG grant O 1674 O VT O This O work O was O partially O supported O by O the O Chongqing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O nos O CSTB2022NSCQ-MSX1417 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Research I-ORG Program I-ORG of I-ORG Chongqing I-ORG Municipal I-ORG Education I-ORG Commission I-ORG Grant O no. O KJZD-K202200513 B-AWARD and O the O Chongqing B-ORG Normal I-ORG University I-ORG Fund I-ORG Grant O no. O 22XLB003 B-AWARD This O work O was O supported O by O the O US O National B-ORG Institutes I-ORG of I-ORG Health I-ORG P50 O GM103297 I-AWARD to O H.M.A O Austrian B-ORG Science I-ORG Fund I-ORG P28725 O and I-AWARD P30370 I-AWARD to O C.K O and O Austrian B-ORG Research I-ORG Promotion I-ORG Agency I-ORG FFG O West O Austrian I-AWARD BioNMR I-AWARD 858017 I-AWARD to O C.K O Funding O for O open O access O charge O US O National O Institutes O of O Health O P50 O GM103297 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No: O 2016YFC0103003 B-AWARD Beijing B-ORG Municipal I-ORG Science I-ORG I-ORG Technology I-ORG Commission I-ORG No: O Z171100001017197 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No: O 31771045 B-AWARD The O funding O body O had O no O role O or O interference O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O cofinanced O 50 O by O the O Government B-ORG of I-ORG La I-ORG Rioja I-ORG and I-ORG FEDER I-ORG Funds I-ORG during O 2019 O and O 2020 O project O PR-07-19 B-AWARD y O PR-08-20 B-AWARD L. O Alti-Palacios O also O wishes O to O thank O INIA B-ORG for O her O predoctoral O contract O FPI-INIA O CPD2016-0115 O This O work O was O also O funded O by O FCT-Fundação B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG a I-ORG Tecnologia I-ORG through O the O CQM O Base O Fund—UIDB/00674/2020 O and O Programmatic O Fund—UIDP/00674/2020 O and O by O ARDITI-Agência B-ORG Regional I-ORG para I-ORG o I-ORG Desenvolvimento I-ORG da I-ORG Investigação I-ORG Tecnologia I-ORG e I-ORG Inovação O through O the O project O M1420-01-0145-FEDER-000005—Centro B-AWARD de O Química O da O Madeira—CQM O Madeira O 14-20 O Program O The O authors O also O acknowledge O the O financial O support O from O Fundação O para O a O Ciência O e O Tecnologia O and O Madeira O 14-2020 O program O to O the O Portuguese B-ORG Mass I-ORG Spectrometry I-ORG Network I-ORG through O the O PROEQUIPRAM O program O M14-20 B-AWARD M1420-01-0145-FEDER-000008 I-AWARD This O research O was O supported O by O the O Basic B-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG No. O 2019B1515120065 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundations I-ORG of I-ORG China I-ORG Grant O No. O 31872687 B-AWARD and O 31370473 B-AWARD and O the O Water B-ORG Pollution I-ORG Control I-ORG and I-ORG Management I-ORG Project I-ORG of I-ORG China I-ORG Grant O No. O 2018ZX07208005 B-AWARD This O research O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2018B030313011 O 2018B030315007 B-AWARD the O Pearl B-ORG River I-ORG Nova I-ORG Program I-ORG of I-ORG Guangzhou I-ORG 201906010011 O and O the O Project B-ORG of I-ORG Swine I-ORG Innovation I-ORG Team I-ORG in I-ORG Guangdong I-ORG Modern I-ORG Agricultural I-ORG Research I-ORG System I-ORG 2018ML1101 O This O research O was O funded O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2019YFD1100205 O National B-ORG Major I-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG of I-ORG China I-ORG 2017ZX07202004 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41571476 O This O work O was O financially O supported O by O the B-ORG Foundation I-ORG for I-ORG scientific I-ORG research I-ORG of I-ORG the I-ORG Rotterdam I-ORG Eye I-ORG Hospital I-ORG SWOO-Flieringa O Rotterdam O the O Netherlands O the B-ORG Theia I-ORG foundation I-ORG Grant O Number O 2010157 B-AWARD Leiden O the O Netherlands O and O the O CZ B-ORG foundation I-ORG Grant O Number O AFVV09-168 B-AWARD Zeist O the O Netherlands O The O funding O organizations O had O no O role O in O the O design O or O conduct O of O this O research O This O study O was O supported O in O part O by O the O National B-ORG Science I-ORG Foundation I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG of I-ORG China I-ORG No. O 81625016 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81772555 B-AWARD and O 81802352 B-AWARD and O the O Shanghai B-ORG Sailing I-ORG Program I-ORG No. O 17YF1402500 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31670851 O 61602332 B-AWARD National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC1306605 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG of I-ORG China I-ORG 18KJD520003 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51702271 O the B-ORG Young I-ORG and I-ORG Middle-aged I-ORG Teachers I-ORG Education I-ORG and I-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province O China O JAT170407 O and O the B-ORG High I-ORG Level I-ORG Talent I-ORG Project I-ORG of I-ORG Xiamen I-ORG University I-ORG of I-ORG Technology O China O YKJ16016R O This O work O was O supported O by O grants O from O Defense B-ORG Advanced I-ORG Research I-ORG Projects I-ORG Agency I-ORG D14AP00048 O FA8650-17-C-7712 O PI O Falk O National B-ORG Institutes I-ORG of I-ORG Health I-ORG 1DP2DA03515601 O PI O Falk O and O a O National B-ORG Cancer I-ORG Institute I-ORG and I-ORG Food I-ORG and I-ORG Drug I-ORG Administration I-ORG Center I-ORG for I-ORG Tobacco I-ORG Products I-ORG pilot I-ORG grant O PIs O Falk O and O Doré O under O P50CA179546 B-AWARD PIs O Robert O Hornik O and O Caryn O Lerman O The O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81071389 O the B-ORG Commonweal I-ORG Technology I-ORG Application I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2015C33101 O and O the B-ORG Technology I-ORG Project I-ORG of I-ORG Wenzhou I-ORG City I-ORG Y20140481 O Centre O National O de O la O Recherche O Scientifique O by O the O HelicaRN O 2010 O BLAN O 1503 O 01 O HeliDEAD O grants O ANR-13-BSV8-0009-01 O from O the O Agence O Nationale O de O la O Recherche O to O N.K.T O European B-ORG Research I-ORG Council I-ORG grant O Magreps O 267 O 862 I-AWARD to O V.C O Programme O grant O from O the O Pierre-Gilles B-ORG de I-ORG Gennes I-ORG Foundation I-ORG FPGG032 O to O N.K.T O V.C O Initiative B-ORG d’Excellence I-ORG program I-ORG from O the O French O State O grant O DYNAMO O ANR-11-LABX-0011-01 O to O N.K.T O Funding O for O open O access O charge O European O Research O Council O grant O Magreps O 267 O 862 O Supports O from O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2016YFB0303505 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 51702121 B-AWARD the O Shandong O Provincial O “Double O First-Class” O University O Construction O Project O the O Taishan O Scholars O Program O and O the B-ORG 111 I-ORG Project I-ORG of I-ORG International I-ORG Corporation I-ORG on I-ORG Advanced I-ORG Cement-based I-ORG Materials I-ORG Grant O No. O D17001 B-AWARD are O greatly O acknowledged O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 51874164 B-AWARD Major B-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG Projects I-ORG in I-ORG Shandong I-ORG Province I-ORG Grant O No. O 2019SDZY02 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Plan I-ORG Announced I-ORG Bidding I-ORG Project I-ORG in I-ORG Shanxi I-ORG Province I-ORG 20191101015 O This O study O was O supported O by O grants O from O the O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG BBSRC O grant O number O RS4949 B-AWARD Royal B-ORG Society I-ORG of I-ORG London I-ORG grant O number O RA3810 B-AWARD and O the O University B-ORG of I-ORG Nottingham I-ORG grant O number O A2B090 B-AWARD This O research O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG of I-ORG China I-ORG BK20201072 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 22078123 O and O 22108091 B-AWARD and O the O Special O Foundation O of O Jiangsu B-ORG Collaborative I-ORG Innovation I-ORG Center I-ORG of I-ORG Regional I-ORG Modern I-ORG Agriculture I-ORG and I-ORG Environmental I-ORG Protection I-ORG HSXT30422 O HSXT30425 B-AWARD This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 52270106 O 22266021 B-AWARD Yunnan B-ORG Major I-ORG Scientific I-ORG and I-ORG Technological I-ORG Projects I-ORG grant O NO. O 202202AG050005 B-AWARD and O Yunnan B-ORG Fundamental I-ORG Research I-ORG Projects I-ORG grant O NO. O 202201AT070116 B-AWARD This O research O was O funded O by O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq I-ORG project O number O 406078/2018-1 B-AWARD CAPES B-ORG PRINT I-ORG Program I-ORG project O number O 88887.310560/2018-00 B-AWARD C.G O and O G.C O thank O FAPERJ B-ORG Fundação O Carlos O Chagas O Filho O de O Amparo O à O Pesquisa O do O Estado O do O Rio O de O Janeiro O process O number O E-26/201.911/2020 B-AWARD E-26/201.912/2020 B-AWARD E-26/200.627/2022 B-AWARD and O E-26/210.391/2022 B-AWARD A.D.A.Z O is O grateful O to O FAPESC B-ORG Fundação O de O Amparo O à O Pesquisa O e O Inovação O do O Estado O de O Santa O Catarina O project O number O IFS2020201000004 B-AWARD This O research O was O supported O by O Sanming B-ORG Project I-ORG of I-ORG Medicine I-ORG in I-ORG Shenzhen I-ORG NO. O SZSM201811071 B-AWARD the O China B-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Projects I-ORG Foundation I-ORG NO. O 2017ZX10303406 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO. O 81673174 B-AWARD the O Shenzhen B-ORG Municipal I-ORG Science I-ORG Technology I-ORG Program I-ORG NO. O JSGG20160429101631739 B-AWARD and O NO.JCYJ20160428142519080 O and O Shenzhen B-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG NO. O 201602004 B-AWARD Danish B-ORG Multiple I-ORG Sclerosis I-ORG Society I-ORG Grant O No. O A31910 B-AWARD and I-AWARD A27996 O VINNMER O Marie O Curie O Industry O Outgoing O grant O Grant O No. O 013-04350 B-AWARD Swedish B-ORG Research I-ORG Council I-ORG Grant O No. O 2014-39102016-03443 B-AWARD Swedish B-ORG Foundation I-ORG for I-ORG Strategic I-ORG Research I-ORG Grant O No. O AM13-0090 B-AWARD Random O Walk O Imaging O AB, O Sweden O H.R.S O holds O a O 5-year O professorship O in O precision O medicine O at O the O Faculty O of O Health O Sciences O and O Medicine O University O of O Copenhagen O which O is O sponsored O by O the O Lundbeck B-ORG Foundation I-ORG Grant O No. O R186-2015-2138 B-AWARD This O work O was O supported O by O the O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG #7172168 O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG #2016YFC1302601 O and O the O Beijing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Key I-ORG Development I-ORG Program I-ORG #D161100000816005 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O manuscript O preparation O The B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51975184 O the B-ORG Changzhou I-ORG Sci I-ORG Tech I-ORG Program I-ORG CE20215051 O and O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2020YFB1312900 O The O authors O gratefully O acknowledge O the O supports O The O study O was O funded O by O the O Academy B-ORG of I-ORG Finland I-ORG grant O no. O 286278 B-AWARD to O Suvi O Ruuskanen O the O Finnish B-ORG National I-ORG Agency I-ORG for I-ORG Education I-ORG grant O no. O TM-15-9960 B-AWARD to O Tom O Sarraude O and O the O University B-ORG of I-ORG Groningen I-ORG grant O to O Ton B-AWARD Groothuis O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Research O Program O funded O by O the O Korea B-ORG Disease I-ORG Control I-ORG and I-ORG Prevention I-ORG Agency I-ORG 2011E3300300 O 2012E3301100 B-AWARD 2013E3301600 B-AWARD 2013E3301601 B-AWARD 2013E3301602 B-AWARD 2016E3300200 B-AWARD 2016E3300201 B-AWARD 2016E3300202 B-AWARD 2019E320100 B-AWARD 2019E320101 B-AWARD 2019E320102 B-AWARD and O 2022-11-007 B-AWARD by O the B-ORG National I-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF I-ORG funded I-ORG by I-ORG the I-ORG Korea I-ORG government I-ORG MSIT O NRF-2020R1F1A1074001 O and O NRF-2019R1A2C2086276 B-AWARD and O by O a O grant O BCRI22079 O BCRI22042 B-AWARD and O BCRI21046 B-AWARD from O the O Chonnam B-ORG National I-ORG University I-ORG Hospital I-ORG Biomedical I-ORG Research I-ORG Institute I-ORG This O research O was O funded O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O No. B-AWARD 42122058 I-AWARD and I-AWARD 41977368 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG grant O number O No. B-AWARD E2021502046 O and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG grant O number O No. B-AWARD 2021MS075 I-AWARD and I-AWARD 2020YJ007 I-AWARD This O work O was O supported O by O the O Scientific B-ORG and I-ORG Technological I-ORG Innovation I-ORG Joint I-ORG Capital I-ORG Projects I-ORG of I-ORG Fujian I-ORG Province I-ORG 2017Y9100 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG 2018J01296 O the O Medical B-ORG Innovation I-ORG Project I-ORG of I-ORG Fujian I-ORG Province I-ORG 2017-CX-19 O the O Startup B-ORG Fund I-ORG for I-ORG Scientific I-ORG Research I-ORG of I-ORG Fujian I-ORG Medical I-ORG University I-ORG 2017XQ2022 O and O the O National B-ORG Clinical I-ORG Key I-ORG Specialty I-ORG Construction I-ORG Project I-ORG General I-ORG Surgery I-ORG of I-ORG China I-ORG [2012]649 O This O study O was O financially O supported O by O the O Universidad B-ORG de I-ORG Oviedo I-ORG UNOV-11-MA-02 O Gobierno B-ORG del I-ORG Principado I-ORG de I-ORG Asturias I-ORG SV-PA-13-ECOEMP-62 O and O Fundación O MEDINA O The O polarimeter O IR, O and O NMR O equipment O used O in O this O work O were O acquired O via O grants O for O scientific O and O technological O infrastructures O from O the O Ministerio B-ORG de I-ORG Ciencia I-ORG e I-ORG Innovación I-ORG Grants O No. O PCT-010000-2010-4 B-AWARD NMR O INP-2011-0016-PCT-010000 B-AWARD ACT6 I-AWARD polarimeter O and O IR O This O study O was O funded O by O grants O from O National B-ORG Key I-ORG Projects I-ORG for I-ORG Infectious I-ORG Diseases I-ORG of I-ORG China I-ORG 2012ZX10002012-007 O 2016ZX10002018-008 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31100629 O 31270863 O 81372755 O 31470794 O 81402082 O 81402085 O 81471621 O 81472227 O 81472376 O 31570803 O 81501999 O 81671628 B-AWARD and O 81672324 B-AWARD Program B-ORG for I-ORG New I-ORG Century I-ORG Excellent I-ORG Talents I-ORG in I-ORG University I-ORG NCET-13-0146 O and O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG 14ZR1406300 O All O these O study O sponsors O have O no O roles O in O the O study O design O in O the O collection O analysis O and O interpretation O of O data O This O work O is O supported O by O grants O from O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 81470745 B-AWARD to O YPP O the O Minister B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Taiwan I-ORG MOST-103-2113-M-007-009-MY2 O to O JWC O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province I-ORG no. O 2014021067 B-AWARD to O LL O and O 2015020754 B-AWARD to O HYW O This O research O was O sponsored O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.30801141 O the B-ORG First I-ORG Affiliated I-ORG Hospital I-ORG of I-ORG China I-ORG Medical I-ORG University I-ORG Foundation I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG fsfh1305 O the O Educational I-ORG Commission I-ORG of I-ORG Liaoning I-ORG Province I-ORG of I-ORG China I-ORG L2010694 O and O the O Liaoning O Provincial O Research O Foundation O for O Science O and O Technology O Program O 2015020480 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG BBSRC O grant O number O BB/M010996/1 B-AWARD BBSRC B-ORG Institute I-ORG Strategic I-ORG Programme I-ORG Grants I-ORG BBS/E/D/20002172 O and O BBS/E/D/30002275 B-AWARD and O Centre B-ORG for I-ORG Environment I-ORG Fisheries I-ORG and I-ORG Aquaculture I-ORG Science I-ORG Cefas I-ORG Seedcorn I-ORG project O DP901W B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81230014 O 81470341 B-AWARD 81520108002 B-AWARD 81500157 B-AWARD the O Key B-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2018C03016-2 O and O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2019C03016 O This O work O is O supported O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No. O 14ZZ2240 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 61603087 B-AWARD and O also O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jilin I-ORG Province I-ORG Grant O No. O 20160101253JC B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 51805055 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG Grant O No. O 2018YFB0106100 B-AWARD and O the O Australian B-ORG Research I-ORG Council I-ORG the O ARC I-AWARD Linkage I-AWARD Project I-AWARD grant I-AWARD LP160101081 O Howard O Hughes O Medical O Institute O to O Y.K O Cancer B-ORG Prevention I-ORG I-ORG Research I-ORG Institute I-ORG of I-ORG Texas I-ORG R1214 O to O I.J.F O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG GM120554 O to O I.J.F O GM53085 B-AWARD to O E.A O GM112435 B-AWARD to O C.M.M O The O Welch B-ORG Foundation I-ORG F-1808 O to O I.J.F O Funding O for O open O access O charge O NIH O This O research O was O supported O in O part O by O the O Bonanza O Creek O Long-Term O Ecological O Research O Program O which O is O funded O by O the O National B-ORG Science I-ORG Foundation I-ORG award O number O DEB-1636476 B-AWARD RR, O TH O the O USDA B-ORG Forest I-ORG Service O Pacific O Northwest O Research O Station O RJVA-PNW-01-JV-11261952-231 O TH O and O a O student O research O grant O from O the O UAF B-ORG Center I-ORG for I-ORG Global I-ORG Change I-ORG I-ORG Arctic I-ORG System I-ORG Research I-ORG 15-010 O BH O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31670788 B-AWARD and O No. O 81172485 B-AWARD the B-ORG Ph.D I-ORG Program I-ORG Foundation I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG No. O 20130171110007 B-AWARD and O Open B-ORG Fund I-ORG of I-ORG Guangdong I-ORG Key I-ORG Laboratory I-ORG of I-ORG Pharmaceutical I-ORG Functional I-ORG Genes I-ORG No.2014B030301028 O and O No.2017B030314021 O This O study O was O financially O supported O by O the O Public B-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Funds I-ORG Projects I-ORG of I-ORG Agriculture I-ORG Grant O No. O 201003075 B-AWARD the O Program B-ORG for I-ORG Changjiang I-ORG Scholars I-ORG and I-ORG Innovative I-ORG Research I-ORG Team I-ORG in I-ORG University I-ORG Grant O No. O IRT_15R62 B-AWARD the O fund O from O Jinjiang O Municipal B-ORG Bureau I-ORG of I-ORG Agriculture I-ORG Fujian I-ORG Province I-ORG Project O Study O on O the O Origin O of O Jinjiang O Horse O with O the O Techniques O of O Genomics O Grant O No. O 201705510411345 B-AWARD and O the O fund O from O Beijing B-ORG Key I-ORG Laboratory I-ORG for I-ORG Genetic I-ORG Improvement I-ORG of I-ORG Livestock I-ORG and I-ORG Poultry I-ORG Grant O No. O Z171100002217072 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Czech B-ORG Science I-ORG Foundation I-ORG Project O No. O CSF O 19-03564S B-AWARD Ministry O of O Education O Youth O and O Sports O of O the O Czech O Republic O Project O No. O LTC19051 O and O Project O No. O LO1409 O Infrastructure O SAFMAT O Project O No. O LM2015088 O Operational O Programme O Research O Development O and O Education O financed O by O European O Structural O and O Investment O Funds O and O the O Czech O Ministry O of O Education O Youth O and O Sports O Project O No. O SOLID21-CZ.02.1.01/0.0/0.0/16_019/0000760 O Russian B-ORG Science I-ORG Foundation I-ORG 19-13-00029 O Russian B-ORG Foundation I-ORG for I-ORG Basic I-ORG Research I-ORG 19-03-00337 O 19-53-26007 B-AWARD This O work O was O supported O by O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2016A050503016 O and O 2016A010105004 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O Number O 2015ZP032 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017A030313097 O Grant B-ORG from I-ORG the I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Hubei I-ORG Province I-ORG 2021BCA114 O Research B-ORG Fund I-ORG of I-ORG the I-ORG Health I-ORG Commission I-ORG of I-ORG Hubei I-ORG Province I-ORG WJ2021M255 O Cancer B-ORG research I-ORG and I-ORG translational I-ORG platform I-ORG project I-ORG of I-ORG Zhongnan I-ORG Hospital I-ORG of I-ORG Wuhan I-ORG University I-ORG ZLYNXM202004 O This O work O was O funded O by O a O postdoctoral O fellowship O to O the O first O author O by O the O Wellcome B-ORG Trust I-ORG grant O reference O number O 213725/Z/18/Z B-AWARD The O article O used O data O generated O in O the O context O of O the O impact O evaluation O of O the O Results-Based O Financing O for O Maternal O and O Newborn O Health O RBF4MNH O Initiative O a O research O project O funded O by O the O United B-ORG States I-ORG Agency I-ORG for I-ORG International I-ORG Development I-ORG under O Translating O Research O into O Action O Cooperative O Agreement O No. O GHS-A-00-09-00015-00 B-AWARD by O the O Norwegian B-ORG Agency I-ORG for I-ORG Development I-ORG Cooperation I-ORG NORAD O and O by O the O Royal O Norwegian O Embassy O in O Lilongwe O The O findings O of O this O study O are O the O sole O responsibility O of O the O authors O and O do O not O necessarily O reflect O the O views O of O USAID O the O United O States O Government O NORAD O or O the O Royal O Norwegian O Embassy O in O Lilongwe O This O work O was O supported O by O Grants O 973 B-ORG 2012CB721004 O the B-ORG National I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31270100 O Wuhan B-ORG Youth I-ORG Chenguang I-ORG Program I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2015070404010181 O and O the O Open O Funding O Project O of O the O State O Key O Laboratory O of O Microbial O Metabolism O MMLKF16-03 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 61562060 B-AWARD the O SingHealth B-ORG Foundation I-ORG Singapore I-ORG under I-ORG its I-ORG Translational I-ORG Research I-ORG Grant I-ORG SHF/FG503P/2012 O Biomedical B-ORG Research I-ORG Council I-ORG Research I-ORG Grant I-ORG 14/1/32/24/002 O the O Goh B-ORG Cardiovascular I-ORG Research I-ORG Grant I-ORG Duke-NUS-GCR/2013/0009 O and O National B-ORG Heart I-ORG Center I-ORG Singapore I-ORG under I-ORG its I-ORG NHCS I-ORG Centre I-ORG Grant I-ORG Seed I-ORG Funding I-ORG NHCS-CGSF/2014/003 O The O collection O of O clinical O data O data O analysis O and O interpretation O and O writing O of O the O manuscript O were O supported O by O grants O from O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFC1101100 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO. O 81471039 B-AWARD No. O 81270893 B-AWARD No. O 81228023 B-AWARD No. O 81401601 B-AWARD and O No.81402202 O Natural B-ORG Science I-ORG Foundation I-ORG Project I-ORG of I-ORG Chongqing I-ORG CSTC2014jcyjjq10006 O CSTC2012jjB10023 B-AWARD and O CSTC2016jcyjA0518 B-AWARD and O Clinical B-ORG Research I-ORG Project I-ORG of I-ORG Xinqiao I-ORG Hospital I-ORG of I-ORG Third I-ORG Military I-ORG Medical I-ORG University I-ORG Yclkt-201421 O This O study O was O funded O by O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U1136605 O Ningxia B-ORG Agricultural I-ORG Breeding I-ORG Program I-ORG NXNYYZ20150103 O and O Program B-ORG for I-ORG Changjiang I-ORG Scholar I-ORG and I-ORG Innovation I-ORG Research I-ORG Team I-ORG in I-ORG University I-ORG IRT1191 O This O research O was O supported O by O the O Department B-ORG of I-ORG Energy I-ORG Feedstock I-ORG Genomics I-ORG Award I-ORG 219086 B-AWARD GN, O WM, O PEB O the O National B-ORG Science I-ORG Foundation I-ORG Science I-ORG Engineering I-ORG and I-ORG Education I-ORG for I-ORG Sustainability I-ORG Award I-ORG 1314095 B-AWARD PEB O and O the O Agriculture B-ORG and I-ORG Food I-ORG Research I-ORG Initiative I-ORG Competitive I-ORG Grant I-ORG no. O 2011-68005-30407 B-AWARD from O the O USDA O National O Institute O of O Food O and O Agriculture O GN O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O is O partially O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG grant O 2018YFC0910401 B-AWARD NSFC B-ORG grant O 61721003 B-AWARD by O the O CZI B-ORG HCA B-AWARD Seed I-AWARD Network I-AWARD Project O The O funding O bodies O have O not O played O any O role O in O the O design O of O the O study O the O collection O analysis O interpretation O of O data O or O the O writing O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Number O 31501413 B-AWARD Shandong B-ORG key I-ORG project I-ORG of I-ORG Research I-ORG I-ORG Development I-ORG plan I-ORG Grant O Number O 2017GSF221019 B-AWARD Young B-ORG doctorate I-ORG Cooperation I-ORG Fund I-ORG Project I-ORG QiLu I-ORG University I-ORG of I-ORG Technology I-ORG Shandong O Academy O of O Sciences O Grant O Number O 2017BSHZ021 B-AWARD Shandong B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Project I-ORG Grant O Number O ZR2017BC072 B-AWARD and O the O Foundation B-ORG of I-ORG Key I-ORG Laboratory I-ORG of I-ORG Industrial I-ORG Fermentation I-ORG Microbiology I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG and I-ORG Tianjin I-ORG Key I-ORG Lab I-ORG of I-ORG Industrial I-ORG Microbiology I-ORG Tianjin O University O of O Science O O Technology O Grant O Number O 2016IM005 B-AWARD This O work O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81402560 B-AWARD 81402281 O O 81772643 O Henan B-ORG Medical I-ORG Program I-ORG 201602072 O and O Henan B-ORG Science I-ORG I-ORG Technology I-ORG Program I-ORG 172102310271 O The O funding O bodies O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O James O Kolasinski O holds O a O Wellcome B-ORG Trust I-ORG Sir O Henry B-ORG Wellcome I-ORG Postdoctoral I-ORG Fellowship O 204696/Z/16/Z O CUBRIC O is O supported O by O a O Strategic O Award O from O the O Wellcome O Trust O 104943/Z/14/Z O This O study O was O supported O by O the O UK, O MEG B-ORG Partnership I-ORG Grant I-ORG MRC/EPSRC O MR/K005464/1).Conflict B-AWARD of O Interest:None O declared O This O research O was O funded O by O the O Clinical B-ORG Research I-ORG Plan I-ORG of I-ORG SHDC O grant O number O SHDC2020CR3070B B-AWARD Shanghai B-ORG Jiao I-ORG Tong I-ORG University I-ORG School I-ORG of I-ORG Medicine I-ORG Two-hundred I-ORG Talent O grant O number O 20161420 B-AWARD Clinical B-ORG Research I-ORG Program I-ORG of I-ORG 9th I-ORG People’s I-ORG Hospital I-ORG affiliated I-ORG to I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG School I-ORG of I-ORG Medicine O grant O number O JYLJ202108 B-AWARD Interdisciplinary B-ORG Program I-ORG of I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University O grant O number O YG2022QN048 B-AWARD and O the O Shanghai B-ORG Clinical I-ORG Research I-ORG Center I-ORG of I-ORG Plastic I-ORG and I-ORG Reconstructive I-ORG Surgery I-ORG supported I-ORG by I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality O grant O number O 22MC1940300 B-AWARD This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2021YFC2600301 O Postgraduate B-ORG Research I-ORG Practice I-ORG Innovation I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG SJCX21_1451 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Higher I-ORG Education I-ORG Institutions I-ORG of I-ORG Jiangsu I-ORG Province I-ORG 20KJB540001 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20190925 O BK20200968 B-AWARD and O Nantong B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG MS12020050 O for O their O financial O supports O to O Nantong O University O We O also O acknowledge O the O financial O support O to O Gangwei B-ORG Pan I-ORG from I-ORG the I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BE2021025 O and O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2021T140346 O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O nos O 31972534 B-AWARD 32272833 B-AWARD Joint B-ORG Research I-ORG Project I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Agriculture I-ORG and I-ORG rural I-ORG affairs I-ORG 19220034 O 19220035 B-AWARD Zhejiang B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Program I-ORG on I-ORG Agricultural I-ORG New I-ORG Variety I-ORG Breeding I-ORG Grant O number O 2021C02068-1 B-AWARD and O Hainan B-ORG Provincial I-ORG Key I-ORG R I-ORG I-ORG D I-ORG Program I-ORG of I-ORG China I-ORG ZDYF2021XDNY296 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31772656 O the O China B-ORG Forage I-ORG and I-ORG Grass I-ORG Research I-ORG System I-ORG CARS-35-04 O and O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG ASTIP-IAS14 O The O funding O body O played O no O role O in O the O design O of O the O study O the O collection O analysis O and O interpretation O of O data O and O the O writing O of O the O manuscript O This O work O was O supported O by O the O China B-ORG Support I-ORG Programs I-ORG 2012BAD09B03 O and O 2015BAD22B02 B-AWARD for O Dry-land O Farming O in O the O twelfth O 5-year O plan O period O the O National B-ORG High-Tech I-ORG Research I-ORG and I-ORG Development I-ORG Programs I-ORG of I-ORG China I-ORG “863 O Program” O for O the O twelfth O 5-Year O Plan O 2013AA102902 O the O Program B-ORG of I-ORG Introducing I-ORG Talents I-ORG of I-ORG Discipline I-ORG to I-ORG Universities I-ORG No. O B12007 B-AWARD and O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG funded O project O 2016M602870 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O ‘Center O for O Bioenergy O Recycling O ASHBACK)’ O project O funded O by O the O Danish B-ORG Council I-ORG for I-ORG Strategic I-ORG Research I-ORG grant O no. O 0603-00587B B-AWARD and O Danish B-ORG Geocenter I-ORG grant O no. O 5298507 B-AWARD AL O was O supported O by O a O Juan O de O la O Cierva O scholarship O from O the O Spanish B-ORG Government I-ORG FJCI-2014-19572 O MZA O was O supported O by O the O European O Union's O Horizon B-ORG 2020 I-ORG I-ORG Research I-ORG and I-ORG Innovation I-ORG Framework I-ORG Programme I-ORG under O the O Marie O Skłodowska-Curie O project O MicroArctic O grant O no. O 675546 B-AWARD FE O and O RR O were O supported O by O the O Danish B-ORG Council I-ORG for I-ORG Independent I-ORG Research I-ORG DFF-4002-00274 O This O work O was O funded O by O the O Basic O Science O Research O Program O grant O no. O 2019R1A2C2084122 B-AWARD and O MRC O grant O 2018R1A5A2020732 O through O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O funded O by O the O Ministry O of O Science O O ICT O MSIT O by O the O Ministry B-ORG of I-ORG Trade I-ORG Industry I-ORG and I-ORG Energy I-ORG under O the O Industrial O Technology O Innovation O Program O 10080726 O 20000843 B-AWARD and O by O the O Ministry B-ORG of I-ORG Health I-ORG and I-ORG Welfare O Republic O of O Korea O HI18C2391 O This O work O was O supported O by O grants O 2019-0641 O from O the O Asan B-ORG Institute I-ORG for I-ORG Life I-ORG Sciences I-ORG Asan I-ORG Medical I-ORG Center O Seoul O Korea O This O study O was O funded O by O Changzhou B-ORG science I-ORG and I-ORG technology I-ORG support I-ORG project I-ORG Social O Development O CE20175021 B-AWARD key B-ORG project I-ORG of I-ORG science I-ORG and I-ORG technology I-ORG development I-ORG fund I-ORG of I-ORG Nanjing I-ORG Medical I-ORG University I-ORG 2017NJMUZD044 O and O Jiangsu B-ORG Maternal I-ORG and I-ORG Child I-ORG Health I-ORG Research I-ORG Projects I-ORG F201842 O Work O in O R.M O laboratory O is O supported O by O grants O from O the O Medical B-ORG Research I-ORG Council I-ORG MR/S007792/1 O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG M008517 O and O Wellcome B-ORG Trust I-ORG 102489/Z/13/Z O This O work O was O supported O by O the O Special B-ORG Fund I-ORG for I-ORG Basic I-ORG Scientific I-ORG Research I-ORG of I-ORG Central I-ORG Public I-ORG Research I-ORG Institutes I-ORG Grant O Numbers O 2016CZ-1 B-AWARD 2018CZ-1 B-AWARD 2018CZ-8 B-AWARD the O Beijing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG No. O Z171100001017076 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81870979 B-AWARD the O Beijing B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG No. O D161100002816004 B-AWARD and O the O Capital B-ORG Health I-ORG Research I-ORG and I-ORG Development I-ORG of I-ORG Special I-ORG No. O 2018-1-6011 B-AWARD This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 51674208/51404208 B-AWARD Department B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Sichuan I-ORG Province I-ORG grant O number O 2018JY0515 B-AWARD State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Molecular I-ORG Engineering I-ORG of I-ORG Polymers I-ORG grant O number O K2017-25 B-AWARD State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Oil I-ORG and I-ORG Gas I-ORG Reservoir I-ORG Geology I-ORG and I-ORG Exploitation I-ORG grant O number O PLC20180103 B-AWARD PetroChina B-ORG Innovation I-ORG Foundation I-ORG grant O number O 2018D-5007-0207 B-AWARD Science B-ORG and I-ORG Technology I-ORG Strategic I-ORG Cooperation I-ORG of I-ORG Nanchong I-ORG city I-ORG and I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Nanchong I-ORG city I-ORG Sichuan I-ORG China I-ORG grant O number O NC17SY4017 B-AWARD And O the O APC O was O funded O by O National O Natural O Science O Foundation O of O China O grant O number O 51674208 O This O work O was O supported O by O the O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG operating O grant O 93804 B-AWARD Natural B-ORG Sciences I-ORG and I-ORG Engineering I-ORG Research I-ORG Council I-ORG of I-ORG Canada I-ORG Discovery O Grant O 418719 B-AWARD and O Canada B-ORG Foundation I-ORG for I-ORG Innovation I-ORG award O 16389 B-AWARD to O B.B O This O work O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O under O Grant O 61701269 B-AWARD and O Grant O 61603224 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG under O Grant O ZR2017BF012 B-AWARD the O Joint B-ORG Research I-ORG Fund I-ORG for I-ORG Young I-ORG Scholars I-ORG in I-ORG Qilu I-ORG University I-ORG of O Technology O Shandong O Academy O of O Sciences O under O Grant O 2017BSHZ005 B-AWARD and O the O Open O Research O Fund O from O Shandong O provincial O Key O Laboratory O of O Computer O Network O under O Grant O SDKLCN-2016-03 B-AWARD The O research O was O supported O by O the O Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG 1610192018111 O 1612382017204 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Henan I-ORG Province I-ORG 162300410329 O and O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG CAAS-ASTIP-2017-ZFRI O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31700272 O and O 31872110 B-AWARD the O Postgraduate O Research O and O Practice O Innovation O Program O of O Jiangsu O Province O KYCX19_2203 O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-10-B3 O the O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O This O research O was O funded O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21772065 O 81673527 O Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG ZR2017MH019 O and O Shandong B-ORG Provincial I-ORG Key I-ORG Research I-ORG Project I-ORG 2017GSF19115 O 2018GSF118158 I-AWARD 2017GSF19111 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81874120 B-AWARD 81572608 B-AWARD Wuhan B-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG No. O 2017060201010170 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Henan I-ORG No. O 162300410266 B-AWARD 172102410021 O This O research O was O funded O by O the O Programa B-ORG Jovens I-ORG Pesquisadores I-ORG INI/Fiocruz O grant O number O INI-003-FIO-19-2-7 B-AWARD This O research O was O also O supported O in O part O by O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq O grant O number O 302796/2017-7 B-AWARD Fundação B-ORG Carlos I-ORG Chagas I-ORG Filho I-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG do I-ORG Rio I-ORG de I-ORG Janeiro I-ORG FAPERJ O grant O numbers O E-26/202.527/2019 B-AWARD E-26/201.441/2021 B-AWARD and O E-26/206.018/2022 B-AWARD and O the O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior—Brazil I-ORG CAPES)—Finance O Code O 001 B-AWARD This O work O was O supported O by O the O Czech B-ORG Science I-ORG Foundation I-ORG grant O number O 18-27648S B-AWARD the O Technology B-ORG Agency I-ORG of I-ORG the I-ORG Czech I-ORG Republic I-ORG grant O number O TE01020028 B-AWARD European B-ORG Regional I-ORG Development I-ORG Fund I-ORG grant O number O CZ.02.1.01/0.0/0.0/16_019/0000729 B-AWARD and O PPLZ B-ORG of I-ORG the I-ORG Czech I-ORG Academy I-ORG of I-ORG Sciences I-ORG grant O number O L200321851 B-AWARD to O SEA O Diffraction O data O were O collected O on O BL14.1 O and O BL14.2 O at O the O BESSY O II O electron O storage O ring O operated O by O the O Helmholtz-Zentrum O Berlin O This O work O was O supported O by O the O Centers B-ORG for I-ORG Disease I-ORG Control I-ORG and I-ORG Prevention I-ORG U01CK000490 O U01CK000633 B-AWARD the O National B-ORG Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases I-ORG National B-ORG Institutes I-ORG of I-ORG Health I-ORG Department I-ORG of I-ORG Health I-ORG and I-ORG Human I-ORG Services I-ORG U19AI110818 O R01AI135114 B-AWARD R01HD102540 B-AWARD the O National O Institutes O of O Health O Ruth O L. O Kirschstein O National O Research O Service O Award O T32HG008962 O from O the O National O Human O Genome O Research O Institute O and O TRIAD O with O funding O in O part O from O the O National B-ORG Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences I-ORG of I-ORG the I-ORG National I-ORG Institutes I-ORG of I-ORG Health I-ORG UL1TR002538 O The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O National O Institutes O of O Health O This O study O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0501605 O Hubei O Province O Technical O Innovation O Special O Project O Foreign O Scientific O and O Technological O Cooperation O Grant O No. O 2019AHB069 O the O Special O Fund O for O Chinese O Agricultural O Research O System O beef/yaks O CARS-37 O and O the O National O Distinguished O Scholars O in O Agricultural O Research O and O Technical O Innovative O Team O The O author O Jie O Wang O was O supported O by O the O International B-AWARD Education I-AWARD Program I-AWARD for I-AWARD Innovative I-AWARD Talents I-AWARD 2016 I-AWARD sponsored O by O the O China B-ORG Scholarship I-ORG Council I-ORG and O International B-AWARD Tuition I-AWARD Fee I-AWARD Scholarship I-AWARD supplied O by O Murdoch B-ORG University I-ORG This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 51605172 B-AWARD and O 51775201 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG of O China O Grant O No. O 2016CFB191 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No. O 2015MS014 B-AWARD This O research O was O supported O by O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG KYZ201843 O and O partly O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG of O China O General O Program O BK20171328 B-AWARD and O the O open O funds O of O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Crop I-ORG Genetics I-ORG and I-ORG Germplasm I-ORG Enhancement I-ORG ZW201813 O The O funding O bodies O were O not O involved O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O as O well O as O in O writing O the O manuscript O This O research O was O supported O by O a O grant O of O the O Korea O Health O Technology O R&D O Project O through O the O Korea O Health O Industry O Development O Institute O KHIDI O funded O by O the O Ministry B-ORG of I-ORG Health I-ORG I-ORG Welfare I-ORG Republic I-ORG of I-ORG Korea I-ORG grant O number O HI17C0659 B-AWARD Basic O Science O Research O Program O through O the O National O Research O Foundation O of O Korea(NRF O funded O by O the O Ministry B-ORG of I-ORG Education I-ORG Republic I-ORG of I-ORG Korea(No O 2017R1A1A2A10000681 B-AWARD and O Hallym B-ORG University I-ORG Research I-ORG Fund I-ORG HURF-2017-59 O Funding O provided O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China-31272620 O Prof O Guangneng O Peng O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China-2016YFD0501009 O Prof O Guangneng O Peng O and O the B-ORG Chengdu I-ORG Giant I-ORG Panda I-ORG Breeding I-ORG Research I-ORG Foundation-CPF2015-4 O Zhijun O Zhong O This O research O was O funded O mainly O by O the O Ministry B-ORG of I-ORG Education I-ORG Youth I-ORG and I-ORG Sports I-ORG of I-ORG the I-ORG Czech I-ORG Republic O scheme O INTER-EXCELLENCE O INTERACTION O grant O number O LTAUSA18154 B-AWARD titled O “Assessment O of O ecosystem O function O based O on O Earth O observation O of O vegetation O quantitative O parameters O retrieved O from O data O with O high O spatial O spectral O and O temporal O resolution” O This O project O is O in O collaboration O with O U.S O partners O P. O Campbell O and O H. O Epstein O Campbell’s O contribution O was O supported O by O NASA B-ORG LCLUC I-ORG Program O grant O number O 80NSSC18K0337 B-AWARD titled O “Prototyping O MuSLI O canopy O Chlorophyll O Content O for O Assessment O of O Vegetation O Function O and O Productivity” O Partial O support O for O manuscript O finalization O and O the O analysis O of O phenolic O compounds O was O funded O through O the O Czech B-ORG Science I-ORG Foundation I-ORG GAČR O grant O number O 21-18532S B-AWARD titled O “Light-induced O protection O mechanisms O based O on O low-molecular-weight O metabolites O and O their O role O in O plant O cross-tolerance O to O high O temperature O and O drought” O This O work O was O supported O by O the O H2020 B-ORG European I-ORG Research I-ORG Council I-ORG ChemBioAP O Knut B-ORG och I-ORG Alice I-ORG Wallenbergs I-ORG Stiftelse I-ORG WAF O Vetenskapsrådet B-ORG 2018-04585 O This O work O was O supported O by O the O National O Institutes O of O Health O and O National B-ORG Cancer I-ORG Institute I-ORG Grants O K01-CA184288 B-AWARD U54-CA155850 B-AWARD U01-CA116850 B-AWARD U54-CA155496 B-AWARD and O P30-CA006973 B-AWARD Dr. O Dean’s O work O is O partially O supported O by O the O National B-ORG Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases I-ORG Johns O Hopkins O University O Center O for O AIDS O Research O Grant O P30-AI094189 B-AWARD and O the O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health I-ORG Grant O R25-MH083620 B-AWARD This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31401935 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province O China O Grant O No. O LQ14C060001 B-AWARD Hangzhou B-ORG Scientific I-ORG and I-ORG Technological I-ORG Program I-ORG 20150932H04 O 20150932H03 B-AWARD and O 20150432B02 B-AWARD This O work O was O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG under O grant O 2016YFC1000703 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O grant O 81300532 B-AWARD Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O grant O LQ17H040001 B-AWARD and O Medical B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG under O grant O 2016KYA120 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31870919 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province I-ORG No. O 20180550597 B-AWARD LiaoNing O Revitalization O Talents O Program O XLYC1807113 O Dalian O Science O and O Technology O Innovation O Fund O No. O 2020JJ25CY015 O and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG DUT19TD12 O This O research O was O funded O by O the O science B-ORG and I-ORG technology I-ORG innovation I-ORG Program I-ORG of I-ORG Hunan I-ORG Province I-ORG 2021RC3091 O Hunan B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 2021JJ20032 O A O Project O Supported O by O Scientific B-ORG Research I-ORG Fund I-ORG of I-ORG Hunan I-ORG Provincial I-ORG Education I-ORG Department I-ORG 20C0971 O The B-ORG New I-ORG Antioxidant I-ORG Feed I-ORG Additive I-ORG Development I-ORG and I-ORG Industrialization I-ORG Project I-ORG of I-ORG Vine I-ORG Tea I-ORG National I-ORG key I-ORG R&D I-ORG program I-ORG of I-ORG China I-ORG 2022YFD1801101 O and O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG No. O CARS-21 B-AWARD This O work O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81670855 O 31671139 B-AWARD for O sample O collection O and O publication O charges O Key B-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG of I-ORG Shandong I-ORG Province I-ORG 2016GSF201100 O 2017GSF218113 B-AWARD 2018GSF118131 B-AWARD 2018GSF118183 B-AWARD for O MS O experiments O and O IHC O TMA O analysis O Yantai B-ORG science I-ORG and I-ORG technology I-ORG plan I-ORG 2017WS102 O and O Doctoral B-ORG fund I-ORG of I-ORG Shandong I-ORG Natural I-ORG Science I-ORG Foundation I-ORG ZR2017BC063 O for O antibody O consumption O BZMC B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG BY2017KYQD08 O for O QDB O analysis O Scientific B-ORG Research I-ORG Foundation I-ORG for I-ORG Returned I-ORG Overseas I-ORG Chinese I-ORG Scholars I-ORG of I-ORG the I-ORG Education I-ORG Office I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG LC2009C21 O for O interpretation O of O data O Development B-ORG Plan I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG Science I-ORG in I-ORG Shandong I-ORG Province I-ORG 2017-237 O for O general O lab O facility O Financial O support O for O this O research O was O provided O by O ViiV B-ORG Healthcare's I-ORG Positive I-ORG Action I-ORG for I-ORG Adolescents I-ORG Programme I-ORG Grant O number O ITCRZF51 B-AWARD the O Wellcome B-ORG Trust I-ORG with O core O funding O for O AHRI O 082384/Z/07/Z O and O joint O funding O under O the O UK O Medical B-ORG Research I-ORG Council I-ORG MRC O UK O Department O for O International O Development O DFID O Concordat O agreement O which O is O supported O by O the O European O Union O under O the O EDCTP2 O programme O reference O MR/K012126/1 O with O AD O receiving O support O G0700837 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O the B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Taiwan I-ORG Grant O number O MOST B-AWARD 107-2911-I-019 I-AWARD 505 O The B-ORG Swedish I-ORG Species I-ORG Initiative I-ORG Diarienr O SLU.dha.2017.4.3-73 O King B-ORG Saud I-ORG University I-ORG Kingdom I-ORG of I-ORG Saudi I-ORG Arabia I-ORG The O Distinguished I-AWARD Scientist I-AWARD Fellowship I-AWARD Program I-AWARD DS O This O study O was O supported O by O a O grant O from O the B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG Shanxi I-ORG Province I-ORG Grant O No. O 201803D31062 B-AWARD for O some O regents O of O the O study O the O Program B-ORG for I-ORG the I-ORG Top I-ORG Young I-ORG Innovative I-ORG Talents I-ORG of I-ORG Shanxi I-ORG Agricultural I-ORG University I-ORG Grant O No. O TYIT201403 B-AWARD for O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 31402156 B-AWARD and O 31873002 B-AWARD for O design O of O the O study O This O work O was O supported O by O PRODEP B-ORG No. O 47310462 B-AWARD DGAPA-PAPIIT-UNAM B-ORG No. O IA200514 B-AWARD and O CONACyT B-ORG No. O CB0237387 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Fundação B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG a I-ORG Tecnologia I-ORG FCT—Portugal O in O the O framework O of O the O strategic O funding O of O UIDB/04469/2020 B-AWARD unit O and O CQUM B-ORG UIDB/00686/2020 O by O LABBELS B-ORG Associate I-ORG Laboratory I-ORG in I-ORG Biotechnology I-ORG Bioengineering I-ORG and I-ORG Microelectromechanical I-ORG Systems O LA/P/0029/2020 B-AWARD and O by O funds O from O FEDER/FCT B-ORG through O the O project O PTDC/MED-ONC/31354/2017 B-AWARD This O work O was O supported O in O part O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2022YFD1400200 B-AWARD and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 32172461 B-AWARD Talents B-ORG of I-ORG Guizhou I-ORG Science I-ORG and I-ORG Technology I-ORG Cooperation I-ORG Platform I-ORG Grant O No. O 2021)5623 B-AWARD Guizhou B-ORG Science I-ORG and I-ORG Technology I-ORG Cooperation I-ORG Foundation I-ORG Grant O No. O ZK(2021)140 B-AWARD The B-ORG Unique I-ORG Feature I-ORG Project I-ORG of I-ORG Guizhou I-ORG Provincial I-ORG Education I-ORG Department I-ORG Grant O No. O KY(2021)056 B-AWARD 17Program O of I-ORG Introducing I-ORG Talents I-ORG of I-ORG Discipline I-ORG to I-ORG Universities I-ORG of I-ORG China I-ORG Grant O No. O 111 B-AWARD Program I-AWARD D20023 O This O work O was O funded O by O the O Spanish O Ministry O of O Economy O and O Competitiveness O through O the O Severo O Ochoa O Program O for O Centres B-ORG of I-ORG Excellence I-ORG in I-ORG R+D+I I-ORG SEV-2012-0262 O through O the O I+D+i B-ORG National I-ORG Plan I-ORG Project O CGL2013-47674-P B-AWARD and O by O the O 7th B-ORG Framework I-ORG Programme I-ORG FP7 O 2007-2013 O of O the O European O Commission O through O a O Marie B-ORG Curie I-ORG Intra-European I-ORG Fellowship I-ORG for I-ORG Career I-ORG Development I-ORG PIEF-GA-2011-299747 O M.I O Sánchez O was O supported O by O a O Ramón O y O Cajal O postdoctoral O contract O from O the O Spanish O Ministry O of O Science O and O Innovation O MICINN O M. O Martínez-Haro O was O supported O by O a O postdoctoral O contract O funded O by O the O Junta B-ORG de I-ORG Comunidades I-ORG de I-ORG Castilla-La I-ORG Mancha I-ORG POST O 2014/7780 O Currently O MMH O holds O a O Juan B-ORG de I-ORG la I-ORG Cierva I-ORG research I-ORG contract I-ORG IJCI-2014-20171 O awarded O by O the O Spanish O Ministry O of O Science O and O Innovation-European O Social O Fund O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 71804093 O Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG ZR2015HL102 O and O Shandong B-ORG Provincial I-ORG Medical I-ORG and I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Project I-ORG 2016WS0478 O We O thank O the O National B-ORG Key I-ORG R I-ORG I-ORG D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC1701900 O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2014CB138304 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81573527 O 81973423 B-AWARD and O Peking B-ORG Union I-ORG Medical I-ORG College I-ORG Discipline I-ORG Construction I-ORG Project I-ORG 201920100901 O for O the O financial O supports O The O funders O have O no O responsibility O in O design O preformation O and O result O interpretation O This O work O was O supported O by O aWellcome O CollaborativeAward O to O G.R.B O M.J.B O and O R.B O grant O numbers O 203257/Z/16/Z B-AWARD 203257/B/16/Z B-AWARD aWellcome O Principal I-ORG Research I-ORG Fellowshipto O E.A.M O grant O number O 210567/Z/18/Z B-AWARD a O Centre O Award O to O theWellcome O Centre I-ORG for I-ORG Human I-ORG Neuroimaging[grant O number O 203147/Z/16/Z B-AWARD The B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O No. O 91423101 B-AWARD I-AWARD 51320105009)The O National I-ORG Key I-ORG Research I-ORG I-ORG Development I-ORG Program I-ORG Grant O No. O 2016YFB1102200)The B-AWARD ‘111’ I-ORG project I-ORG by I-ORG the I-ORG State I-ORG Administration I-ORG of I-ORG Foreign I-ORG Experts I-ORG Affairs I-ORG and I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG Grant O No. O B07014 B-AWARD The O material O was O collected O and O sorted O in O the O frame O of O the O project O KuramBio O with O the O financial O support O of O the O PTJ B-ORG German I-ORG Ministry I-ORG for I-ORG Science I-ORG and I-ORG Education O grant O 03G0223A B-AWARD and O BMBF B-ORG grant O 03G0250A B-AWARD to O Prof O Dr. O Angelika O Brandt O University O of O Hamburg O now O Senckenberg O Museum O Frankfurt O Germany O The O analysis O of O the O material O was O supported O by O the O Polish B-ORG National I-ORG Science I-ORG Centre I-ORG grant O to O Anna O Jażdżewska O University O of O Lodz O project O No. I-AWARD 2014/15/D/NZ8/00289 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O project O was O funded O by O the O Special O Funds O for O Agro-scientific B-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG 201203031 O the O Science B-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG 2015BAD26B00 O and O the O Scientific B-ORG and I-ORG Technological I-ORG Project I-ORG of I-ORG Henan I-ORG Province I-ORG 152102110067 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81874120 B-AWARD 81572608 B-AWARD Wuhan B-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG No. O 2017060201010170 B-AWARD Henan B-ORG science I-ORG and I-ORG technology I-ORG open I-ORG cooperation I-ORG project I-ORG No. O 162106000021 B-AWARD This O research O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51778521 O the O National B-ORG Key I-ORG Research I-ORG Program I-ORG No. O 2016YFC0400706 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2018M643808XB O and O the O Key O Laboratory O of O Education O Department O of O Shaanxi O province O No. O 19JS039 O The O study O were O supported O by O the B-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG CAAS-ASTIP-2013-OCRI O the B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG Hubei I-ORG province I-ORG 201620000001048 O Wuhan B-ORG cutting-edge I-ORG application I-ORG technology I-ORG fund I-ORG 2018020401011303 O and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG Central I-ORG Non-profit I-ORG Scientific I-ORG Institution I-ORG 1610172017003 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 52006041 B-AWARD the O Guangdong B-ORG Academy I-ORG of I-ORG Sciences I-ORG Nos O 2021GDASYL-20210103101 B-AWARD 2020GDASYL-20200101001 B-AWARD 2022GDASZH-2022010109 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2021YFB3701204 B-AWARD and O the O Guangdong B-ORG Major I-ORG Project I-ORG of I-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Re-search I-ORG No. O 2020B0301030006 B-AWARD This O research O was O supported O by O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No O LQ17H060001 B-AWARD Medical B-ORG and I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG Grant O No O 2019326687 B-AWARD Medical B-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Hangzhou I-ORG City I-ORG Grant O No O 20170533B38 B-AWARD and O Zhejiang B-ORG province I-ORG natural I-ORG science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No O LQ17H160012 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81502241 B-AWARD and O by O the O foundation O of O the O Army O Medical O Center O of O PLA O Army B-ORG Medical I-ORG University I-ORG 2014YLC01 O by O the O foundation O of O the O Chongqing B-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG cstc2016shms-ztzx10005 O The O study O was O supported O by O research O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81960268 B-AWARD Key B-ORG Project I-ORG of I-ORG Basic I-ORG Research I-ORG in I-ORG Yunnan I-ORG Province I-ORG No. O 201901S070102 B-AWARD Medical B-ORG center I-ORG of I-ORG Yunnan I-ORG Health I-ORG Commission I-ORG No. O XZ20191001 B-AWARD The O beneficiaries O of O the O funds O were O Sheng O Lu O and O Yongqing O Xu. O Sheng O Lu O is O the O corresponding O author O and O designed O and O provided O technical O guidance O for O this O study O This O work O was O supported O by O the O Guangzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Key I-ORG Program I-ORG 201707020015 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31571625 O Guangdong B-ORG Province I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2018B020202012 O and O South B-ORG China I-ORG Agricultural I-ORG University I-ORG Doctor I-ORG Student I-ORG Joint I-ORG Training I-ORG Project I-ORG 2019LHPY013 O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81271226 O the O RGC B-ORG General I-ORG Research I-ORG Fund I-ORG 17117715 O and O the O Health B-ORG and I-ORG Medical I-ORG Research I-ORG Fund I-ORG of O Hong O Kong O Government O 01121726 O RRG-08 B-AWARD and O 04152256 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 31730098 B-AWARD 31430088 O the O earmarked B-ORG fund I-ORG for I-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG Grant O No. O CARS-45 B-AWARD Hunan B-ORG Provincial I-ORG Natural I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG Grant O No. O 2017NK1031 B-AWARD and O the O Cooperative B-ORG Innovation I-ORG Center I-ORG of I-ORG Engineering I-ORG and I-ORG New I-ORG Products I-ORG for I-ORG Developmental I-ORG Biology I-ORG of I-ORG Hunan I-ORG Province I-ORG Grant O No. O 20134486 B-AWARD This O work O was O supported O by O Tianjin B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG 15ZXJZSY00010 O to O Y.-M.Li O National B-ORG Key I-ORG R&D I-ORG Plan I-ORG 2017YFC1307600 O to O Y.-M.Li O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81570335 O to O X. O Zhou O and O Sanming O Project O of O Medicine O in O Shenzhen O to O J.-M O Niu O Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Committee I-ORG Special I-ORG Funding I-ORG for I-ORG Future I-ORG Industry I-ORG JCYJ20170412140326739 O to O J.-M O Niu O The O Funding O body O was O not O involved O in O the O design O of O the O study O collection O analysis O and O interpretation O of O data O or O the O writing O of O the O manuscript O This O study O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81460063 B-AWARD Guangxi B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 2014GXNSFDA118024 B-AWARD and O the B-ORG Health I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG Guangxi I-ORG No. O S2019094 B-AWARD This O study O received O grant O support O from B-ORG the I-ORG Chinese I-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG Major O Project O Grant O No. O 2012ZX10004-220 B-AWARD China B-ORG UK I-ORG Global I-ORG Health I-ORG Support I-ORG Programme I-ORG Grant O No. O GHSP-CS-OP1 B-AWARD and O International B-ORG Collaboration I-ORG Project I-ORG from I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Grant O No. O 2010DF33970 B-AWARD as O part O of O their O program O towards O malaria O control O and O malaria O elimination O The O funders O had O no O role O in O study O design O of O the O trials O or O in O the O design O of O the O analysis O data O collection O decision O to O publish O or O preparation O of O the O manuscript O Funding O was O provided O by O CASTEP B-ORG Grant O No. O China-Africa B-AWARD science I-AWARD and I-AWARD technology I-AWARD program O The O study O was O funded O by O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG BBSRC O through O Building O Out O Vector-borne O diseases O in O sub-Saharan O Africa O the O BOVA O Network O Grant O number O BOVA007 B-AWARD FOO O was O also O funded O by O Wellcome B-ORG Trust I-ORG Intermediate I-ORG Fellowship I-ORG in I-ORG Public I-ORG Health I-ORG and I-ORG Tropical I-ORG Medicine I-ORG Grant O number O WT102350/Z/13/Z B-AWARD and O the O Howard B-ORG Hughes I-ORG Medical I-ORG Institute I-ORG HHMI)-Gates O International O Scholarship O Grant O number O OPP1099295 B-AWARD Funded O by O US-CDC B-ORG Cooperative I-ORG AgreementU50/CCU2444 O 5U5IIP000335 O Remigio O M. O Olveda O Ministry B-ORG of I-ORG Education I-ORG Culture I-ORG Sports I-ORG Science I-ORG and I-ORG Technology I-ORG JapanGrant-in-Aid O from I-AWARD the I-AWARD Japan I-AWARD Initiative I-AWARD for I-AWARD Global I-AWARD Research I-AWARD Network I-AWARD on I-AWARD Infectious I-AWARD Diseases O Hitoshi O Oshitani O Japan B-ORG Science I-ORG and I-ORG Technology I-ORG Agency/Japan I-ORG International I-ORG Cooperation I-ORG Agencythe O Science I-AWARD and I-AWARD Technology I-AWARD Research I-AWARD Partnership I-AWARD for I-AWARD Sustainable I-AWARD Development O Hitoshi O Oshitani O JSPS B-ORG KAKENHIJP15H05281,Taro O Kamigak O This O work O was O jointly O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2018A030313094 O the O Social B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Project I-ORG of I-ORG Dongguan I-ORG No. O 20185071521641 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81303155 O and O the O Project O for O Young O Innovative O Talents O in O Ordinary O Higher O University O of O Guangdong O Province O No. O 2018GkQNCX050 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Zhengrong O Chen O grant O number O 81401296 B-AWARD Wei O Ji, O grant O number O 81570016 B-AWARD Suzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG Zhengrong O Chen O grant O number O SYS201350 B-AWARD Yongdong O Yan O grant O number O SYS201435 B-AWARD Science B-ORG and I-ORG Technology I-ORG Projects I-ORG of I-ORG Jiangsu I-ORG Provincial I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Zhengrong O Chen O Q201403 B-AWARD Science B-ORG and I-ORG Technology I-ORG Projects I-ORG of I-ORG Chinese I-ORG Traditional I-ORG Medicine I-ORG Bureau I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Zhengrong O Chen O grant O number O YB2015176 B-AWARD and O Science B-ORG and I-ORG Technology I-ORG Projects I-ORG of I-ORG Suzhou I-ORG sanitary I-ORG bureau I-ORG Yongdong O Yan O grant O number O LCZX201409 B-AWARD Social B-ORG Development I-ORG Projects I-ORG of I-ORG Suzhou I-ORG Yongdong O Yan O grant O number O SS201537 B-AWARD Projects B-ORG of I-ORG National I-ORG Provincial I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Chuanhe O Liu O grant O number O 201502025 B-AWARD Jiangsu O Province's O Social O Development O Project O Chuangli O Hao O BE2016676 O This O work O was O supported O by O National B-ORG TCM I-ORG Standardisation I-ORG Programme I-ORG Xin-Sheng-Hua I-ORG granule I-ORG ZYBZH-C-JS-34 O Postgraduate B-ORG Research I-ORG and I-ORG Practice I-ORG Innovation I-ORG Programme I-ORG of I-ORG Jiangsu I-ORG Province I-ORG SJCX18_0453 O and O College B-ORG Students I-ORG Innovative I-ORG Training I-ORG Programme I-ORG of I-ORG Nanjing I-ORG University I-ORG of I-ORG Chinese I-ORG Medicine I-ORG 201710315139 O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. B-AWARD 81371911 O the B-ORG Application I-ORG of I-ORG Clinical I-ORG Features I-ORG of I-ORG Capital I-ORG City I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG China I-ORG BEIJING I-ORG Special I-ORG subject I-ORG Z181100001718180 O and O Beijing B-ORG Science I-ORG and I-ORG Technology I-ORG New I-ORG Star I-ORG Project I-ORG Z171100001017198 O This O work O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81373257 B-AWARD and O 81703668 B-AWARD Guangdong B-ORG Natural I-ORG Science I-ORG Fund I-ORG No. O 2017A030310396 B-AWARD Y. O Pommier O and O K. O Agama O are O supported O by O the B-ORG Center I-ORG for I-ORG Cancer I-ORG Research I-ORG the I-ORG Intramural I-ORG Program I-ORG of I-ORG the I-ORG National I-ORG Cancer I-ORG Institute I-ORG NIH I-ORG Z01 O BC I-AWARD 006161–17 O This O work O was O financially O supported O by O Guangzhou B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG No.201607010101 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.31501788 O Guangdong B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG No.2015A020209078 O No.2015B070701016 B-AWARD and O the O the O Construction O Conservation O and O Evaluation O of O Flower O Germplasm O Resources O Garden O Subproject O of O Construction O Conservation O and O Evaluation O of O Crop O Germplasm O Resources O Garden O Project O in O Guangdong O Province O This O work O has O been O supported O by O the O EU O FP7 O ProHealth O project O no. O 613574 B-AWARD RO0516 B-AWARD project O of O the O Czech B-ORG Ministry I-ORG of I-ORG Agriculture I-ORG and O AdmireVet O project O CZ.1.05/2.1.00/01.0006–ED0006/01/01 B-AWARD from O the O Czech B-ORG Ministry I-ORG of I-ORG Education O The O commercial O partner O CCPA O was O a O member O of O research O consortium O of O FP7 B-ORG EU I-ORG project O similar O to O the O other O co-authors O The O CCPA O company O did O not O fund O work O presented O in O this O manuscript O at O all O The O funder O provided O partial O support O in O the O form O of O salaries O for O authors O IR, O but O did O not O have O any O additional O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O specific O roles O of O these O authors O are O articulated O in O the O ‘author O contributions’ O section O Medical B-ORG Research I-ORG Council I-ORG MR/M001288/1 O Wellcome B-ORG Trust I-ORG 105727/Z/14/Z O British B-ORG Heart I-ORG Foundation I-ORG PG/14/79/31102 O and I-AWARD PG/15/12/31280 O Sudden O Adult O Death O Syndrome O SADS O UK O Society O and O the O Fundamental O Research O Grant O Scheme O FRGS/2014/SKK01/PERDANA/02/1 O Ministry O of O Education O Malaysia O This O work O was O supported O by O the O Joint B-ORG Fund I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG and O the O Karst O Science O Research O Center O of O Guizhou O Province O No. O U1812401 B-AWARD the O National O Natural O Science O Foundation O of O China O grant O no. O 32160656 B-AWARD the O Science–Technology B-ORG Support I-ORG Program I-ORG of I-ORG Guizhou I-ORG Province I-ORG grant O no. O 2020)1Y134 B-AWARD 2021 B-AWARD YB243 O the O “Hundred” B-ORG Level I-ORG Talent I-ORG Foundation I-ORG of I-ORG Guizhou I-ORG Province I-ORG grant O no. O GCC B-AWARD 2022]023-1 O and O the O Cultivation B-ORG Program I-ORG of I-ORG Guizhou I-ORG University I-ORG grant O no. O 2019]09 B-AWARD The O work O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31670952 I-AWARD and O No. B-AWARD 81702921 O Graduate B-ORG research I-ORG and I-ORG innovation I-ORG foundation I-ORG of I-ORG Chongqing I-ORG China I-ORG grant O No.CYB18029 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No.2018CQDYSG0021 O This O research O was O funded O by O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG O Brasil O CAPES)-Finance O Code I-AWARD 001 O The O authors O thank O also O the O financial O support O provided O by O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq O BR, O Grant O No, O 402.289/2013-7 B-AWARD 304.667/2015-5 I-AWARD 432.001/2016-6 I-AWARD and I-AWARD 305.991/2017-5 O Fundação B-ORG Carlos I-ORG Chagas I-ORG Filho I-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG do I-ORG Rio I-ORG de I-ORG Janeiro I-ORG FAPERJ O BR, O Grant O No. O E-26/202.918/2015 B-AWARD and I-AWARD E-26/010.001273/2016 O and O Instituto B-ORG Nacional I-ORG de I-ORG Ciência I-ORG e I-ORG Tecnologia I-ORG de I-ORG Fármacos I-ORG e I-ORG Medicamentos I-ORG INCT-INOFAR O BR, O Grant O No O 465.249/2014 B-AWARD Research O in O the O laboratory O is O funded O by O an O American B-ORG Heart I-ORG Association I-ORG Scientist O Development O Grant O 14SDG18700043 O an O OK-INBRE O grant O funded O by O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG of O the O National O Institutes O of O Health O P20GM103447 O and O an O Oklahoma B-ORG Center I-ORG for I-ORG the I-ORG Advancement I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Health O Research O grant O HR O 13-003 O Mass O spectrometry O work O was O performed O at O the O Proteomics O i3S O Scientific O Platform O that O has O support O from O the O Fundação B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG a I-ORG Tecnologia I-ORG ROTEIRO/0028/2013 O LISBOA-01-0145 B-AWARD FEDER-022125 O This O work O was O supported O by O an O Intra-Mural O grant O Ovinomics O II) O from O the O Centre B-ORG for I-ORG Integrative I-ORG Mammalian I-ORG Research I-ORG of I-ORG Ross I-ORG University I-ORG School I-ORG of I-ORG Veterinary I-ORG Medicine I-ORG St. O Kitts O and O Nevis O West O Indies O Author O AM O Almeida O acknowledges O funding O from O LEAF B-ORG UID/AGR/04129/2013 O Supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81603290 O Project B-ORG of I-ORG Qiangwei I-ORG Youth I-ORG Medical I-ORG Talent I-ORG of I-ORG Jiangsu I-ORG Provincial I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG QNRC2016594 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20161594 O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC1603400 O and O 2017YFC1600404 B-AWARD Research O funding O was O provided O by O the O Tiroler B-ORG Wissenschaftsfonds I-ORG TWF-2016-1-9 O to O C.D O LIT B-ORG Project O LIT-2019-7_SEE-113 B-AWARD to O D.B O FFG B-ORG Project O 880919 B-AWARD to O C.W O and O D.B O and O the O JKU B-ORG MED-CALL O Covid I-AWARD 19 O This O paper O was O supported O by O the O Johannes O Kepler O Open O Access O Publishing O Fund O This O research O was O funded O by O The O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 42076094 B-AWARD No. O 82273844 B-AWARD the O Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Action I-ORG Plan I-ORG Grant O No. O 21S11902400 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2021M702495 B-AWARD Outstanding B-ORG Leaders I-ORG Training I-ORG Program I-ORG of I-ORG Pudong I-ORG Health I-ORG Bureau I-ORG of I-ORG Shanghai I-ORG Grant O No. O PWRl2020-08 B-AWARD This O work O was O supported O in O part O by O the O Entrusted B-ORG Project I-ORG of I-ORG National I-ORG commission I-ORG on I-ORG health I-ORG and I-ORG health I-ORG of I-ORG China I-ORG No. O 2019]099 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG of I-ORG China I-ORG 2016YFC0106300 O and O the O Nature B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG 2019FFB03902 O The O funder O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O authors O declare O that O there O are O no O conflicts O of O interest O in O this O study O The O authors O acknowledge O support O by O Breast B-ORG Cancer I-ORG Now I-ORG KCL-BCN-Q3 O the O Medical O Research O Council O MR/X012476/1 O Mengyuan O Li O was O awarded O funds O by O the O China B-ORG Scholarship I-ORG Council I-ORG 202008440233 O Elena O Alberts O was O funded O by O the O UK O Medical O Research O Council O Doctoral O Training O Programme O Victoire O Boulat O was O awarded O funds O by O Cancer B-ORG Research I-ORG UK I-ORG RE18831 O This O study O has O been O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81572102 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG 2017YFC1105003 O and O Director B-ORG Foundation I-ORG of I-ORG Nanfang I-ORG Hospital I-ORG of I-ORG Southern I-ORG Medical I-ORG University I-ORG 2018B017 O This O work O was O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant I-ORG 81572487 O and O 81402060 B-AWARD the B-ORG Special I-ORG Foundation I-ORG for I-ORG Taishan I-ORG Scholars I-ORG No. O tshw201502056 B-AWARD Department B-ORG of I-ORG Science I-ORG I-ORG Technology I-ORG of I-ORG Shandong I-ORG Province I-ORG 2015ZDXX0801A01 O and O 2014kjhm0101 B-AWARD Shandong B-ORG Provincial I-ORG Outstanding I-ORG Medical I-ORG Academic I-ORG Professional I-ORG Program I-ORG Fundamental I-ORG Research I-ORG Funds I-ORG of I-ORG Shandong I-ORG University I-ORG 2016JC019 O Stiftelsen B-ORG Kristian I-ORG Gerhard I-ORG Jebsen I-ORG Helse-Vest I-ORG Haukeland I-ORG Hospital I-ORG The I-ORG Norwegian I-ORG Cancer I-ORG Society I-ORG The I-ORG Norwegian I-ORG Research I-ORG Council I-ORG and I-ORG the I-ORG Norwegian I-ORG Centre I-ORG for I-ORG International I-ORG Cooperation I-ORG in I-ORG Education I-ORG SIU O UTF-2014/10047 O We O acknowledge O the O use O of O the O Illumina O Hiseq O 2000 O platform O purchased O using O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31401709 O We O also O thank O the O Hainan B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 20153130 O the O Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG for I-ORG Chinese I-ORG Academy I-ORG of I-ORG Tropical I-ORG Agricultural I-ORG Sciences I-ORG No.19CXTD-33 O and O the B-ORG Young I-ORG Elite I-ORG Scientists I-ORG Sponsorship I-ORG Program I-ORG by I-ORG CSTC I-ORG CSTC-QN201704 O for O financial O support O This O work O was O financially O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 21677040 B-AWARD the B-ORG China I-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG no. O 2015M582188 B-AWARD and O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Henan I-ORG Province I-ORG no. O 182300410121 B-AWARD This O work O was O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC81670006 O Shanghai B-ORG Leading I-ORG Talent I-ORG Program I-ORG 2016036 O and O Shanghai B-ORG Hospital I-ORG Development I-ORG Center I-ORG Program I-ORG 16CR3036A O This O work O was O funded O by O Shanghai B-ORG Municipal I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG Project I-ORG 201540027 O and O 20174Y0236 O the O seed O fund O program O of O Shanghai B-ORG University I-ORG of I-ORG Medicine I-ORG and I-ORG Health I-ORG Sciences I-ORG HSMF-17-22-031 O and O SPF-18-20-15-001 B-AWARD Municipal B-ORG Human I-ORG Resources I-ORG Development I-ORG Program I-ORG for I-ORG Outstanding I-ORG Young I-ORG Talents I-ORG in I-ORG Medical I-ORG and I-ORG Health I-ORG Sciences I-ORG in I-ORG Shanghai I-ORG 2017YQ048 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017M610278 O and O Shanghai B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 18ZR1431700 O This O research O was O funded O by O the O Henry B-ORG Lester I-ORG Trust I-ORG Registered O charity O No. O 313892 B-AWARD to O YC O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O grant O number O 72121001 B-AWARD 72071055 B-AWARD to O SL O the O Engineering B-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG EPSRC O grant O code O EP/V051008/1 B-AWARD to O LGP O This O work O was O supported O by O the O US O National B-ORG Institutes I-ORG of I-ORG Health I-ORG Grant O 1R15GM104833-01 B-AWARD the O US O National B-ORG Science I-ORG Foundation I-ORG Grants O DBI O 1624654 B-AWARD and O MCB O 1714778 B-AWARD and O the O Kennesaw B-ORG State I-ORG University I-ORG Foundation O Foundation O Fellow I-AWARD in I-AWARD Biochemistry O This O work O was O supported O by O the O Public B-ORG Welfare I-ORG Technology I-ORG Research I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Province I-ORG LGF18H160029 O the O Jinhua B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 2016-3-005 O the O Key B-ORG Program I-ORG of I-ORG Jinhua I-ORG Municipal I-ORG Science I-ORG I-ORG Technology I-ORG Bureau I-ORG 2018-3-001d O and O the O Key B-ORG Program I-ORG of I-ORG Scientific I-ORG Research I-ORG of I-ORG Jinhua I-ORG Central I-ORG Hospital I-ORG JY2016-1-02 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81602625 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2016A030310096 O 2018A030313122 O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017A010105013 O the O Pearl B-ORG River I-ORG S&T I-ORG Nova I-ORG Program I-ORG of I-ORG Guangzhou I-ORG 201710010011 O and O the O Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG JCYJ20170302145059926 O JCYJ20180305163658916 I-AWARD JCYJ20180228175059744 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG grant O 1U01HG00848801 O the O National B-ORG Science I-ORG Foundation’s I-ORG Computer I-ORG and I-ORG Network I-ORG Systems I-ORG grant O 1305430 O as O well O as O the O Army B-ORG Research I-ORG Laboratory I-ORG under O Cooperative O Agreement O Number O W911NF-16-2-0110 B-AWARD The O funders O had O no O role O in O study O design O data O collection O or O analysis O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 62104090 B-AWARD 11604133 B-AWARD and O 62205011 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG No. O ZR2017QA013 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Plan I-ORG of I-ORG Youth I-ORG Innovation I-ORG Team I-ORG for I-ORG Universities I-ORG of I-ORG Shandong I-ORG Province I-ORG No. O 2019KJJ019 B-AWARD the O Open B-ORG Project I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Superhard I-ORG Materials I-ORG Jilin O University O No. O 201503 B-AWARD and O 201612 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG buctrc202122 O the O Research B-ORG Funding I-ORG of I-ORG Liaocheng I-ORG University I-ORG No. O 318012016 B-AWARD 318051610 B-AWARD 318052136 B-AWARD and O 318051612 B-AWARD the O Open B-ORG Research I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG Key I-ORG Laboratory I-ORG of I-ORG Quantum I-ORG Technology I-ORG and I-ORG Device I-ORG No. O 20220401 B-AWARD the O Open B-ORG Research I-ORG Project I-ORG of I-ORG Special I-ORG Display I-ORG and I-ORG Imaging I-ORG Technology I-ORG Innovation I-ORG Center I-ORG of I-ORG Anhui I-ORG Province I-ORG No. O 2022AJ05001 B-AWARD This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41471349 O the O National B-ORG Key I-ORG Project I-ORG of I-ORG Scientific I-ORG and I-ORG Technical I-ORG Supporting I-ORG Programs I-ORG Funded I-ORG by I-ORG Ministry I-ORG of I-ORG Science I-ORG I-ORG Technology I-ORG of I-ORG China I-ORG 2013BAC03B02 O the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 863 O Program O 2012AA12A304 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2014kJJCA02 O This O work O is O supported O by O grants O from O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDA01030505 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81571391 O 30900847 O 81200410 B-AWARD 81401166 B-AWARD and O Nanjing B-ORG Medical I-ORG Science I-ORG Development I-ORG Project I-ORG JQ2014004 O ZKX16042 B-AWARD This O work O was O supported O by O grants O from O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0502300 O the B-ORG China I-ORG Agricultural I-ORG Research I-ORG System I-ORG CARS-37 O and O the O Special B-ORG Fund I-ORG for I-ORG Agro-scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG 201503134 O This O work O was O supported O by: O Czech B-ORG Science I-ORG Foundation I-ORG O P505/11/1459 B-AWARD awarded O to O AE O http://www.gacr.cz/en O Grant B-ORG Agency I-ORG of I-ORG Charles I-ORG University I-ORG in I-ORG Prague I-ORG – O 760216 B-AWARD awarded O to O MH; O Grant O Agency O of O Charles O University O in O Prague O – O SVV B-AWARD awarded O to O MH. O This O research O was O funded O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2021 O YFC2902604 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 52174262 O Key B-ORG Specialized I-ORG Research I-ORG and I-ORG Development I-ORG Breakthrough I-ORG Program I-ORG in I-ORG Henan I-ORG Province I-ORG 212102310378 O 222102320088 B-AWARD 222102240089 B-AWARD Key B-ORG Scientific I-ORG Research I-ORG Program I-ORG Plan I-ORG of I-ORG Colleges I-ORG and I-ORG Universities I-ORG in I-ORG Henan I-ORG Province I-ORG 21B530007 O and O Cultivation B-ORG Project I-ORG of I-ORG Fundamental I-ORG Research I-ORG for I-ORG Young I-ORG Teachers I-ORG in I-ORG Zhengzhou I-ORG University I-ORG JC21549022 O B.A.K O is O supported O by O the O U.S O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health I-ORG K01MH104310 O R21MH111280 B-AWARD A.N O is O supported O by O the O Medical B-ORG Research I-ORG Council I-ORG UK O MR/N021886/1 O MR/P020348/1 B-AWARD D.R.S O is O a O Distinguished O Fellow O supported O by O the O Medical O Psychiatry O Alliance O and O the O Academic O Scholars O Award O from O the O Department O of O Psychiatry O at O the O University O of O Toronto O V.P O is O supported O by O the O Wellcome B-ORG Trust I-ORG 106919/Z/15/Z O and O NIMH O U19MH113211 O The O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31570271 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2010HQ054 O and O the O Project B-ORG of I-ORG Shandong I-ORG Province I-ORG Higher I-ORG Educational I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG J15LE51 O Luzia O Grabherr O was O supported O by O the O Swiss B-ORG National I-ORG Science I-ORG Foundation I-ORG PBBEP1-144848 B-AWARD G. O Lorimer O Moseley O was O supported O by O the O National B-ORG Health I-ORG I-ORG Medical I-ORG Research I-ORG Council I-ORG of I-ORG Australia I-ORG ID O 1061279 B-AWARD this O work O was O supported O by O a O NHMRC B-ORG Project I-ORG Grant O awarded O to O G. O Lorimer O Moseley O ID O 1008017 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O generously O supported O by O the O Wellcome B-ORG Trust I-ORG Institutional I-ORG Strategic I-ORG Support I-ORG Award I-ORG grant O no. O 204909/Z/16/Z B-AWARD J.R O acknowledges O the O financial O support O of O the O EPSRC B-ORG Centre I-ORG for I-ORG Predictive I-ORG Modelling I-ORG in I-ORG Healthcare I-ORG grant O no. O EP/N014391/1 B-AWARD and O from O an O EPSRC B-ORG New I-ORG Investigator I-ORG Award I-ORG grant O no. O EP/R03124X/1 B-AWARD E.L O acknowledges O the O financial O support O of O the O Dunhill B-ORG Medical I-ORG Trust I-ORG grant O no. O R386/114 B-AWARD This O work O was O supported O by O the O European B-ORG Union I-ORG as I-ORG a I-ORG NEST I-ORG New I-ORG and I-ORG Emerging I-ORG Science I-ORG and I-ORG Technology I-ORG Project O no. O 517133 B-AWARD ‘Brain O Respiratory O and O Cardiac O Causalities O in O Anaesthesia’ O BRACCIA O by O the O Engineering B-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG EPSRC I-ORG UK I-ORG grant O no. O EP/100999X1 B-AWARD and O in O part O by O the O ARRS B-ORG Slovenia I-ORG program O no. O P20232 B-AWARD This O work O was O supported O by O grants O of O Key O Program O of O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O China O NO. O 2017B030311015 B-AWARD Natural O Science O Foundation O of O Guangdong O Province O China O NO. O 2015A030313536 B-AWARD Medical B-ORG Research I-ORG Fund I-ORG of I-ORG Guangdong I-ORG Province I-ORG China O NO. O A2017317 B-AWARD National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG NO. O 2017YFC1310200 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO. O 81671275 B-AWARD NO. O 81501112 B-AWARD The O grants O of O Key O Program O of O Natural O Science O Foundation O of O Guangdong O Province O provide O financial O aid O to O the O data O collection O of O the O manuscript O grants O of O natural O Science O Foundation O of O Guangdong O Province O contribute O to O the O analyzed O data O of O the O manuscript O grants O of O Medical O Research O Fund O of O Guangdong O Province O and O National O Key O R&D O Program O of O China O offer O interpretation O of O data O two O grants O of O National O Natural O Science O Foundation O of O China O pay O fee O for O polishing O English O language O of O the O manuscript O and O publication O charges O This O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81403052 O Science B-ORG and I-ORG Technology I-ORG Department I-ORG Project I-ORG from I-ORG Jilin I-ORG Province I-ORG of I-ORG China I-ORG 20190304017YY O National B-ORG key I-ORG research I-ORG special I-ORG project I-ORG of I-ORG China I-ORG 2019YFC1710070).The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O work O was O funded O in O large O part O by O the O US O National B-ORG Science I-ORG Foundation I-ORG award O 1416860 O to O the O City O University O of O New O York O the O Population O Council O the O National O Center O for O Atmospheric O Research O NCAR O and O the O University O of O Colorado O at O Boulder O Additional O support O was O provided O for O author O Balk O at O the O City O University O of O New O York O via O an O Andrew O Carnegie O Fellowship O #G-F-16-53680 O from O the O Carnegie B-ORG Corporation I-ORG of I-ORG New I-ORG York O Partial O funding O for O author O Leyk O was O provided O through O the O Eunice B-ORG Kennedy I-ORG Shriver I-ORG National I-ORG Institute I-ORG of I-ORG Child I-ORG Health I-ORG and I-ORG Human I-ORG Development I-ORG of O the O National O Institutes O of O Health O under O award O numbers O R21 O HD098717 O 01A1 O and O P2CHD066613 B-AWARD The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O National O Institutes O of O Health O Partial O funding O for O this O work O was O also O provided O through O the O Humans O Disasters O and O the O Built O Environment O program O of O the O National O Science O Foundation O award O number O 1924670 B-AWARD Author O Montgomery O received O partial O funding O from O the O Eunice O Kennedy O Shriver O National O Institute O of O Child O Health O and O Human O Development O of O the O National O Institutes O of O Health O under O award O number O R03 O HD096193-02 B-AWARD and O also O from O internal O funds O supporting O the O Population O Council’s O Population O Environmental O Risks O and O Climate O Change O PERCC O research O program O Funding O for O preparation O of O the O India O data O received O additional O support O from O the O European B-ORG Commission I-ORG Contract O number O 2018.CE.16.BAT.050 O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31560422 B-AWARD Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG of I-ORG Guizhou I-ORG Province I-ORG Qiankehe O zhicheng I-AWARD No. I-AWARD 2019]2396 O Science B-ORG and I-ORG Technology I-ORG Foundation I-ORG of I-ORG Guizhou I-ORG Province I-ORG of I-ORG China I-ORG Grant O No. O Qiankehe B-AWARD J I-AWARD zi I-AWARD 2015]2052 O Scientific B-ORG Research I-ORG Foundation I-ORG for I-ORG Returned I-ORG Scholars I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG Grant O No. O Jiaowaisiliu B-AWARD 2015]1098 O Foundation B-ORG of I-ORG Guizhou I-ORG University I-ORG Grant O No. O Guidarenjihezi B-AWARD 2014]14 O Construction O Construction B-ORG Program I-ORG of I-ORG Biology I-ORG First-class I-ORG Discipline I-ORG in I-ORG Guizhou I-ORG Grant O No. I-AWARD GNYL[2017]009 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Financial O support O for O this O study O was O provided O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG http://www.nsfc.gov.cn O to O Xue-Ping O Zhou O Grant O number O 31390420 B-AWARD National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG http://program.most.gov.cn O to O Yin-Quan O Liu O Grant O number O 2018YFD0201200 B-AWARD and O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG http://123.127.160.231 O grant O number:CARS-23-D07 O to O Yin-Quan O Liu O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Guangdong B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2016A030313105 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG to I-ORG Jinan I-ORG University I-ORG 21616339 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31571408 O the O Program B-ORG of I-ORG Introducing I-ORG Talents I-ORG of I-ORG Discipline I-ORG to I-ORG Universities I-ORG B14036 O and O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG R01GM100474-4 O This O work O was O supported O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81572831 O 81700977 B-AWARD and O 81560362 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Research I-ORG Project I-ORG of I-ORG Education I-ORG Department I-ORG of I-ORG Liaoning I-ORG Province I-ORG LK201616 O and O Foundation B-ORG for I-ORG New I-ORG Teacher I-ORG of I-ORG China I-ORG Medical I-ORG University I-ORG 1210516018 O This O research O was O supported O by O a O grant O EDU/40881 O to O R.P O and O K.A O from O the O Nuffield B-ORG Foundation I-ORG to O the O second O and O last O authors O TEDS O is O supported O by O a O programme O grant O to O R.P O from O the O UK O Medical B-ORG Research I-ORG Council I-ORG MR/M021475/1 O and I-AWARD previously I-AWARD G0901245 I-AWARD to O R.P O with O additional O support O from O the O US O National B-ORG Institutes I-ORG of I-ORG Health I-ORG AG046938 O to O R.P O and O the O European B-ORG Commission I-ORG 602768 O 295366 B-AWARD to O R.P O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0500202 O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC1200100 O and O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31570027 O I-AWARD 81772142 O Dr. O Feng O is O a O recipient O of O the O national O “Young O 1000 O Talents” O Award O of O China O Innovative B-ORG Medicines I-ORG Initiative I-ORG Joint I-ORG Undertaking I-ORG 115583 O European B-ORG Union’s I-ORG Seventh I-ORG Framework I-ORG Programme I-ORG FP7/2007-2013 O EFPIA O companies’ O in O kind O contribution O Academic O and O SME O partners O Wellcome B-ORG Trust I-ORG Investigator I-ORG Award I-ORG 110072/Z/15/Z O to O A.M O BBSRC B-ORG UK) O BB/J004561/1 O to O A.M O John O Innes O Foundation O to O A.M O The O open O access O publication O charge O for O this O paper O has O been O waived O by O Oxford O University O Press—NAR O Editorial O Board O members O are O entitled O to O one O free O paper O per O year O in O recognition O of O their O work O on O behalf O of O the O journal O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 52103067 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20191045 O and O the O Opening B-ORG Project I-ORG of I-ORG Zhejiang I-ORG Key I-ORG Laboratory I-ORG of I-ORG Clean I-ORG Dyeing I-ORG and I-ORG Finishing I-ORG Technology I-ORG QJRZ2108 O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81860629 O Major B-ORG Project I-ORG of I-ORG Guangxi I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG AA17292001 O the B-ORG Open I-ORG Funds I-ORG of I-ORG the I-ORG Guangxi I-ORG Key I-ORG Laboratory I-ORG of I-ORG Tumor I-ORG Immunology I-ORG and I-ORG Microenvironmental I-ORG Regulation I-ORG 2018KF003 O Project O for O Promoting O Scientific O Research O Ability O of O Staff O in O The O Affiliated O Hospital O of O Guilin O Medical O University O 2018glmcy034 O and O State B-ORG Key I-ORG Laboratory I-ORG for I-ORG Chemistry I-ORG and I-ORG Molecular I-ORG Engineering I-ORG of I-ORG Medicinal I-ORG Resources I-ORG Guangxi O Normal O University O CMEMR2018-B06 O This O work O was O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG Graduate I-ORG Research I-ORG Fellowship I-ORG under O grant O no O 1937968 B-AWARD This O project O was O also O supported O by O the O National B-ORG Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute I-ORG through O grants O NIH B-AWARD R21 I-AWARD HL108263 O NIH B-AWARD R01 I-AWARD HL114406 O and O NIH B-AWARD R01 I-AWARD HL143484 O This O research O was O conducted O in O space O renovated O using O funds O from O a O NIH O construction O grant O C06 O RR12463 O awarded O to O Case B-ORG Western I-ORG Reserve I-ORG University I-ORG This O study O was O funded O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG with O program O no.2013PY134 O DJ O Development B-ORG Programme I-ORG 863 I-ORG Programme I-ORG of I-ORG China I-ORG with O grant O no. O 2012AA101101 B-AWARD www.863.gov.cn O DJ O Specialized B-ORG Research I-ORG Fund I-ORG for I-ORG the I-ORG Doctoral I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG with O grant O no.20130146110026 O www.cutech.edu.cn O DJ O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81902664 I-AWARD 81872071 I-AWARD and I-AWARD 81672502 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Nos O 2016YFC1302204 I-AWARD and I-AWARD 2017YFC1308600 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Chongqing I-ORG No. O cstc2019jcyj-zdxmX0033 O This O work O was O supported O by O the O Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG No. O RCBS20200714114940262 B-AWARD the O General O Higher O Education O Project O of O Guangdong B-ORG Provincial I-ORG Education I-ORG Department I-ORG No. O 2020ZDZX3082 B-AWARD 2022ZDZX4101 I-AWARD 2021ZDZX4064 O and O the O Stable O Supporting O Programme O for O Universities B-ORG of I-ORG Shenzhen I-ORG No. O 20200825181232001 B-AWARD There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O is O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51078007 O 51378027 I-AWARD and I-AWARD 51578015)(http://www.nsfc.gov.cn O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 8162010 O http://www.bjnsf.org O and O Beijing B-ORG Talent I-ORG Foundation I-ORG of I-ORG BJUT I-ORG 2013-JH-L06)。All O the O fundings O are O received O by O JG. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O the O Applied B-ORG Technology I-ORG Research I-ORG Demonstration I-ORG and I-ORG Extension I-ORG Program I-ORG of I-ORG Hainan I-ORG Province I-ORG No. O ZDXM2015006 B-AWARD the O Marine B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Hainan I-ORG Province I-ORG No. O XH201403 B-AWARD Major B-ORG Scientific I-ORG and I-ORG Technological I-ORG Program I-ORG of I-ORG Hainan I-ORG Province I-ORG No. O ZDKJ2016009 B-AWARD the O Scientific B-ORG Research I-ORG and I-ORG Trial I-ORG Manufacture I-ORG Program I-ORG of I-ORG Sanya I-ORG No. O 2014CZ09 B-AWARD the O Institutional B-ORG Science I-ORG and I-ORG Technology I-ORG Cooperation I-ORG Program I-ORG of I-ORG Sanya I-ORG No. O 2015YD07).The B-AWARD funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O nos O 51603032 B-AWARD and O 31870542 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG grant O nos O 2572018BB01 B-AWARD 2572018CP01 B-AWARD and O 2572017EB06 B-AWARD and O Postdoctoral B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 2017M621230 B-AWARD This O research O was O funded O by O the O projects O PID2019-104205GB-C21 B-AWARD from O the O Spanish B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Innovation O Finally O we O acknowledge O funding O through O the O Talent O Attraction O Postdoctoral O Fellowship O from O CAM B-ORG ref O 2018-T2/TIC-10616 B-AWARD The O support O of O CONACyT B-ORG A1-S-25341 O and O DGAPA-PAPIIT B-ORG IN111720 O and O IN218323 B-AWARD is O also O gratefully O acknowledged O This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC1706200 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31870073 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Shanghai I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Action I-ORG Plan I-ORG 17JC1402400 O Shanghai B-ORG Rising-Star I-ORG Program I-ORG China I-ORG 19QA1402700 O the B-ORG 111 I-ORG Project I-ORG China I-ORG B18022 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities O China O 22221818014 O Research O Program O of O State O Key O Laboratory O of O Bioreactor O Engineering O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 51974339 B-AWARD and O 51674270 B-AWARD National B-ORG Major I-ORG Project I-ORG No. O 2017ZX05009-003 B-AWARD Research B-ORG Institute I-ORG of I-ORG Petroleum I-ORG Exploration I-ORG Development I-ORG of I-ORG China I-ORG National I-ORG Petroleum I-ORG Cooperation I-ORG HX20201095 O and O Foreign B-ORG Expert I-ORG Project I-ORG of I-ORG the I-ORG Belt I-ORG and I-ORG Road I-ORG Innovation I-ORG Talents I-ORG Exchange I-ORG DL2022122001 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 31770403 B-AWARD 31370399 I-AWARD 31570390 I-AWARD and I-AWARD 31670390 O Jilin B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG grant O number O 20180101272JC B-AWARD and O the O Jilin B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG Natural I-ORG Science I-ORG Foundation I-ORG grant O number O 20190201269JC B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Studies O of O pol O ζ O in O our O laboratory O are O funded O by O National B-ORG Institutes I-ORG of I-ORG Health I-ORG CA193124 O Department B-ORG of I-ORG Defense I-ORG W81XWH-17-10239 O Grady O F. O Saunders O Ph.D O Distinguished O Research O Professorship O to O R.D.W O S.K.M O was O supported O by O a O Research O Training O Grant O award O from O the O Cancer B-ORG Prevention I-ORG and I-ORG Research I-ORG Institute I-ORG of I-ORG Texas I-ORG RP170067 O The O open O access O publication O charge O for O this O paper O has O been O waived O by O Oxford O University O Press O –NAR O This O work O was O supported O by O the O Czech B-ORG Science I-ORG Foundation I-ORG 16-08916S O the O Ministry B-ORG of I-ORG Education I-ORG Youth I-ORG and I-ORG Sports I-ORG of I-ORG the I-ORG Czech I-ORG Republic I-ORG LD15086 O LM2015055 B-AWARD and O by O the O research O concept O of O the O Institute B-ORG of I-ORG Microbiology I-ORG of I-ORG the I-ORG CAS I-ORG RVO61388971 O LZ O was O supported O by O the O Grant B-ORG Agency I-ORG of I-ORG the I-ORG Charles I-ORG University I-ORG 260214 O Research O grant O support O was O provided O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O Project O Nos O 81874061 B-AWARD Hubei B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Guiding I-ORG Project I-ORG 2018CFC846 O Hubei O Provincial O Natural O Science O Foundation O Guiding O Project O 2018CFC846 O and O The B-ORG 7th I-ORG Wuhan I-ORG Young I-ORG and I-ORG Middle-aged I-ORG Backbone I-ORG Talent I-ORG of I-ORG Medical I-ORG Training I-ORG Project I-ORG 2019 I-ORG 2019 O No. I-AWARD 87 O They O played O an O important O role O in O the O study O design O collection O analysis O and O interpretation O of O data O and O manuscript O writing O This O work O was O supported O by O the B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Tianjin I-ORG 17ZXMFSY00060 O the O Key B-ORG Laboratory I-ORG Fund I-ORG Project I-ORG of I-ORG the I-ORG Second I-ORG Hospital I-ORG of I-ORG Tianjin I-ORG Medical I-ORG University I-ORG 2017ZDSYS14 O and O the B-ORG Education I-ORG Commission I-ORG Research I-ORG Project I-ORG of I-ORG Tianjin I-ORG 2017KJ208 O The O funder O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O M.A.S.P O L.G O A.d.S O and O A.M O were O supported O by O the O University B-ORG of I-ORG Luxembourg I-ORG IRP O ASTROSYS O A.M O was O supported O by O the O Luxembourg B-ORG Institute I-ORG of I-ORG Health I-ORG and I-ORG the I-ORG Luxembourg I-ORG Centre I-ORG for I-ORG Systems I-ORG Biomedicine I-ORG MIGLISYS O K.S O was O supported O by O the O Luxembourg B-ORG National I-ORG Research I-ORG Fund I-ORG FNR O through O the O FNR-PRIDE O program O NEXTIMMUNE O for O doctoral O education O PRIDE/11012546/NEXTIMMUNE O This O study O was O funded O by O the B-ORG Opening I-ORG Project I-ORG of I-ORG the I-ORG Key I-ORG Laboratory I-ORG of I-ORG Biology I-ORG and I-ORG Genetic I-ORG Improvement I-ORG of I-ORG Oil I-ORG Crops I-ORG Ministry I-ORG of I-ORG Agriculture I-ORG P. I-ORG R. I-ORG China I-ORG 2017007 O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-14 O the B-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG CAAS-ASTIP-2013-OCRI O the O Opening O Project O of O the O Huanghuaihai O Key O Laboratory O of O Cotton O Genetic O Improvement O and O Cultivation O Physiology O Ministry O of O Agriculture O P. O R. O China O 2016KL03 O the O Central I-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG 1610172018007 O and O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG of I-ORG China I-ORG ZR2018LC014 O The O funding O bodies O did O not O participate O in O the O design O of O the O study O data O analysis O or O writing O of O the O manuscript O This O work O was O supported O by O The B-ORG National I-ORG Science I-ORG Fund I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG of I-ORG China I-ORG to O Zhang O Grant O No. O 31425023 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG to O Zhang O Grant O No. O 31272340 B-AWARD the O Program B-ORG for I-ORG Changjiang I-ORG Scholars I-ORG and I-ORG Innovative I-ORG Research I-ORG Team I-ORG in I-ORG University I-ORG IRT13081 O and O a O Science B-ORG and I-ORG Technology I-ORG Foundation I-ORG Project I-ORG 2012FY110803 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O is O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31771414 O the O Program B-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Talents I-ORG in I-ORG Universities I-ORG of I-ORG Henan I-ORG Province I-ORG 18HASTIT041 O the O 111 O Project#D16014 O and O Yunnan B-ORG Tobacco I-ORG Company I-ORG 2018530000241001 O The O funders O made O no O significant O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O writing O of O the O manuscript O Research O was O funded O by O The O Engineering B-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG EPSRC O grant O EP/T013133/1 B-AWARD to O M.C O and O the O Royal B-ORG Academy I-ORG of I-ORG Engineering I-ORG Research O Fellowship O RF201617\16\23 O to O M.C O The O Wellcome O Centre O for O Integrative O Neuroimaging O is O supported O by O core O funding O from O the O Wellcome O Trust O grant O 203139/Z/16/Z O Also O support O from O the O BHF B-ORG Centre I-ORG of I-ORG Research I-ORG Excellence I-ORG Oxford I-ORG grant O RE/13/1/30181 B-AWARD to O A.T.H O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81371472 O and O U1404811 B-AWARD the O National B-ORG Key I-ORG Basic I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 973 I-ORG Grant O 2011CB707800 B-AWARD the O Medical B-ORG Science I-ORG and I-ORG Technology I-ORG Foundation I-ORG of I-ORG Henan I-ORG Province I-ORG 201702131 O the O Open B-ORG Project I-ORG Program I-ORG of I-ORG the I-ORG National I-ORG Laboratory I-ORG of I-ORG Pattern I-ORG Recognition I-ORG NLPR I-ORG 201600010 O This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC1001901 O and O 2017YFA0102801 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31671540 O 81771579 B-AWARD and O 81501327 B-AWARD Guangdong B-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG Planning I-ORG Project I-ORG 2015B020228002 O and O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG Grant O No. O 2014A020213017 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 61771119 B-AWARD 31170956 I-AWARD and I-AWARD 61805113 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG Grant O Nos O 2017A030313034 B-AWARD and I-AWARD 2018A030310224 O Shenzhen O Science O and O Technology O Innovation O Council O Grant O Nos O JCYJ20170817111349280 O and O KQTD2016030111203005 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG Grant O No. O F2018501063 B-AWARD Fundamental O Research O Funds O for O the O Central O Universities O Grant O Nos O N162304007 O and O N162304008 O Science O and O Technology O Research O Funds O for O Higher O Education O of O Hebei O Province O Grant O No. O ZD2015209 O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81801474 O the O National O Natural O Science O Fund O of O China O 81871716 O the B-ORG Science I-ORG and I-ORG Technology I-ORG Fund I-ORG of I-ORG Shenzhen I-ORG JCYJ20180306172502097 O Science B-ORG and I-ORG technology I-ORG special I-ORG fund I-ORG of I-ORG Longhua I-ORG District I-ORG 2017096 O and O The B-ORG Science I-ORG and I-ORG Technology I-ORG Fund I-ORG of I-ORG Guangzhou I-ORG 201707010019 O These O funders O just O provide O funds O and O not O undertake O other O roles O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81973233 O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Province I-ORG China I-ORG 2021C02062 O the O Scientific B-ORG Research I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Sci-Tech I-ORG University I-ORG 17042058-Y O the O Special B-ORG Program I-ORG for I-ORG Research I-ORG and I-ORG Development I-ORG of I-ORG Zhejiang I-ORG Sci-Tech I-ORG University I-ORG 2019Y009 O Zhejiang B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG New I-ORG Young I-ORG Talent I-ORG Program I-ORG for I-ORG College I-ORG Students I-ORG NO. O 2022R406A034 B-AWARD and O Postdoctoral B-ORG research I-ORG startup I-ORG funding I-ORG by I-ORG Zhejiang I-ORG Sci-Tech I-ORG University I-ORG 22042342-Y O This O work O was O supported O by O the O Young B-ORG Ph.D I-ORG Fund I-ORG for I-ORG Higher I-ORG Education I-ORG in I-ORG Gansu I-ORG Province I-ORG 2022QB-085 O Funds B-ORG for I-ORG Excellent I-ORG Ph.D I-ORG of I-ORG Gansu I-ORG Province I-ORG 22JR5RA844 O Fostering B-ORG Foundation I-ORG for I-ORG the I-ORG Excellent I-ORG Ph.D I-ORG Dissertation I-ORG of I-ORG Gansu I-ORG Agricultural I-ORG University I-ORG YB2022001 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31760755 O This O research O was O funded O by O 973 B-ORG Program I-ORG and I-ORG China I-ORG National I-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG 2015CB659400 O 2016YFA0301100 B-AWARD 2016YFA0302000 B-AWARD and O 2018YFA0306201 B-AWARD and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 91750102 O 11774063 B-AWARD 11727811 B-AWARD and O 11604355 B-AWARD The O research O of O L.S O was O further O supported O by O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG 17ZR1442300 O 17142200100 B-AWARD This O work O is O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No.52206220 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jilin I-ORG Province I-ORG Grant O No.20210101088JC O and O Jilin B-ORG Science-technology I-ORG Innovation I-ORG and I-ORG Development I-ORG Plan I-ORG of I-ORG China I-ORG Grant O No. O 20190104133 B-AWARD This O work O was O supported O by O the O National B-ORG Science I-ORG I-ORG Technology I-ORG Pillar I-ORG Program I-ORG during I-ORG the I-ORG Twelfth I-ORG Five-year I-ORG Plan I-ORG Period I-ORG 2013BAD01B07 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 30972021 O the O Excellent B-ORG Doctoral I-ORG Program I-ORG of I-ORG Shanxi I-ORG Province I-ORG SXYBKY201727 O and O the O Funding O for O Doctoral B-ORG Research I-ORG of I-ORG Shanxi I-ORG Agricultural I-ORG University I-ORG 2017YJ21 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG Reseach I-ORG and I-ORG Development I-ORG Plant I-ORG No.2017YFC1702500 O for O material O collection O and O RNA-seq O the O Major B-ORG Science I-ORG and I-ORG Technique I-ORG Programs I-ORG in I-ORG Yunnan I-ORG Province I-ORG No.2016ZF001 O for O determination O of O primary O metabolite O and O hormone O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O U1402262 O for O bioinformatic O analysis O the O Yunnan O Ten O Thousand O Talents O Plan O Young O O Elite O Talents O Project O YNWR-QNBJ-2018-047 O and O the O project O of O young O and O middle-aged O talent O of O Yunnan O province O No. O 2019HB019 O for O writing O and O publishing O manuscript O This O work O was O funded O by O the O Swiss B-ORG National I-ORG Science I-ORG Foundation I-ORG project O 310030_184662 B-AWARD and O the O South B-ORG African I-ORG Medical I-ORG Research I-ORG Council I-ORG MRC O Flagship O Project O MALTB-Redox O with O funds O from O the O National O Treasury O under O its O Economic O Competitiveness O and O Support O Package O UID O MRC-RFA-UFSP-01–2013 I-AWARD RKH O and O by O the O South B-ORG African I-ORG National I-ORG Research I-ORG Foundation I-ORG SA O NRF O grant O UID O 129135 O RKH O This O work O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81572407 B-AWARD 81602112 B-AWARD 81672405 B-AWARD Key B-ORG project I-ORG of I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG No. O 4210016041 B-AWARD Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG Nos O 2015A030313096 B-AWARD 2016A030313184 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangzhou I-ORG China I-ORG No. O 4250016043 B-AWARD Grant B-AWARD 2013 I-AWARD 163 I-AWARD from O Key B-ORG Laboratory I-ORG of I-ORG Malignant I-ORG Tumor I-ORG Molecular I-ORG Mechanism I-ORG and I-ORG Translational I-ORG Medicine I-ORG of I-ORG Guangzhou I-ORG Bureau I-ORG of I-ORG Science I-ORG and I-ORG Information I-ORG Technology O Grant O KLB09001 B-AWARD from O the O Key B-ORG Laboratory I-ORG of I-ORG Malignant I-ORG Tumor I-ORG Gene I-ORG Regulation I-ORG and I-ORG Target I-ORG Therapy I-ORG of I-ORG Guangdong I-ORG Higher I-ORG Education I-ORG Institutes I-ORG This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 52001304 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Province I-ORG of I-ORG China I-ORG grant O numbers O 2008085QE259 B-AWARD and O 2108085ME142 B-AWARD Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Inner I-ORG Mongolia I-ORG Autonomous I-ORG Region I-ORG grant O number O 2022YFDZ0004 B-AWARD and O the O Major B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Anhui I-ORG Province I-ORG grant O number O 202003c08020002 B-AWARD This O project O was O funded O by O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Taiwan I-ORG MOST O 104-2320-B-038-006 B-AWARD to O KHL O Taipei B-ORG Medical I-ORG University I-ORG TMU101-AE1-B19 O and I-AWARD TMU104-AE2-I02-5 I-AWARD to O KHL O Taipei B-ORG Medical I-ORG University-Shuang I-ORG Ho I-ORG Hospital I-ORG 104TMU-SHH-10 O to O KHL O and O the O proposal O of O the O Ministry B-ORG of I-ORG Health I-ORG and I-ORG Welfare I-ORG MOHW O 104-TDU-B-212-124-001 B-AWARD to O YY O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81572460 O 81972304 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFA0507900 O Young B-ORG Talent I-ORG Project I-ORG of I-ORG Third I-ORG Military I-ORG Medical I-ORG University I-ORG 2017R007 O to O Hu O CJ O the O Frontiers B-ORG in I-ORG Medicine I-ORG Project I-ORG of I-ORG Xinqiao I-ORG Hospital I-ORG Third I-ORG Military I-ORG Medical I-ORG University I-ORG 2018YQYLY010 O to O Hu O CJ) O and O Youth B-ORG Breeding I-ORG Project I-ORG of I-ORG Third I-ORG Military I-ORG Medical I-ORG University I-ORG 2016XPY16 O to O Wu O YR O This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O no. O 81573089 B-AWARD and O 81302294 B-AWARD Tianjin B-ORG Health I-ORG Bureau I-ORG Science I-ORG Foundation I-ORG Project I-ORG Grant O no. O 2015KZ061 B-AWARD and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG CAMS I-ORG Grant O no. O 2016ZX310068 B-AWARD This O study O was O supported O by O the O National B-ORG Institute I-ORG of I-ORG Diabetes I-ORG and I-ORG Digestive I-ORG and I-ORG Kidney I-ORG Diseases I-ORG grant O K24DK093699 B-AWARD R01DK118038 B-AWARD R01DK120861 B-AWARD Principal O Investigator O PI O Leonard O Egede O MD O National B-ORG Institute I-ORG on I-ORG Minority I-ORG Health I-ORG and I-ORG Health I-ORG Disparities I-ORG R01MD013826 O PI: O Egede/Walker O American B-ORG Diabetes I-ORG Association I-ORG 1-19-JDF-075 O PI: O Walker O and O Advancing B-ORG a I-ORG Healthier I-ORG Wisconsin/Clinical O Translational O Science O Award O at O the O Medical O College O of O Wisconsin O UL1TR001436 O and O KL2TR001438 B-AWARD KL2 O PI: O Ozieh O This O work O was O supported O financially O by O Foundation B-ORG from I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2018C02003 O LGN18C170005 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81673663 O Modern B-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG of I-ORG China I-ORG CARS-22-ZJ0105 O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG CIFMS I-ORG 2016-I2M-3-015 B-AWARD and O Key O Laboratory O of O Creative O Agriculture(pilot O run O Ministry O of O Agriculture O P.R O China O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O a O Key B-ORG Project I-ORG of I-ORG Natural I-ORG Science I-ORG Foundation I-ORG from I-ORG Department I-ORG of I-ORG Education I-ORG Anhui I-ORG Provincial I-ORG Grant O number O 03087060 B-AWARD to O ZX O a O Key B-ORG Natural I-ORG Science I-ORG Foundation I-ORG from I-ORG Department I-ORG of I-ORG Education I-ORG Anhui I-ORG Provincial I-ORG Grant O Number O 2013A110 B-AWARD to O EJ O a O Foundation B-ORG of I-ORG Anhui I-ORG Provincial I-ORG Key I-ORG Disciplines I-ORG of I-ORG Biology I-ORG Grant O Number O 2014JXJS002 B-AWARD 2014SKQJ016 B-AWARD to O EJ O and O Anhui O Agricultural O University O Foundation O for O Stability O and O Introduction O of O Talent O Funding O for O open O access O charge O Key O Project O of O Natural O Science O Foundation O of O the O Anhui O Provincial O Education O Department O Financial O support O was O provided O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31870389 O Opening B-ORG Foundation I-ORG of I-ORG Key I-ORG Laboratory I-ORG of I-ORG Resource I-ORG Biology I-ORG and I-ORG Biotechnology I-ORG in I-ORG Western I-ORG China I-ORG Northwest I-ORG University I-ORG Ministry I-ORG of I-ORG Education I-ORG ZSK2017002 O and O National B-ORG Science I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG Shaanxi I-ORG 2019JM356 O The O funders O provided O funds O for O this O study O including O the O design O of O the O study O the O experimental O work O and O analysis O This O study O was O supported O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31372464 O to O EMZ O and O No. O 31402233 O to O QZ, O Technology B-ORG Research I-ORG and I-ORG innovation I-ORG of I-ORG Shaanxi I-ORG province I-ORG 2015NY170 O to O YNS O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2452015035 O to O YNS O 2014YB013 O to O TFD O and O 2452016048 O to O QZ. O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O grant O no. O 31825022 B-AWARD and O 31772153 B-AWARD Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG from I-ORG Sichuan I-ORG Province I-ORG grant O no. O 2018JZ0072 B-AWARD to O Xuewei O Chen O NSFC O grant O no. O 32001523 B-AWARD to O Jiangxue O Wan O NSFC O grant O no. O 31871920 B-AWARD and O International B-ORG Cooperation I-ORG and I-ORG Exchange I-ORG Program I-ORG of I-ORG Sichuan I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG grant O no. O 2020YFH0137 B-AWARD to O Min O He. O This O work O was O supported O by O grants O PAPIIT B-AWARD IN210514 I-AWARD and O PAPIIT B-AWARD IN203718 I-AWARD from O the O National B-ORG Autonomous I-ORG University I-ORG of I-ORG México I-ORG DGAPA-UNAM O and O 285802 B-AWARD from O the O National B-ORG Council I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG CONACyT O to O Marco O A. O Villanueva O Raúl O E. O Castillo-Medina O was O supported O by O fellowship O 255464 B-AWARD from O CONACyT O The O Association O of O Marine O Laboratories O of O the O Caribbean O paid O the O open O access O fee O for O publication O of O this O work O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG #81872380 O 81970864 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Chongqing I-ORG cstc2018jscx-mszdX0039 O cstc2015jcyjBX0047 B-AWARD the O Chongqing B-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG Research I-ORG Project I-ORG 2015HBRC004 O and O the O Chongqing B-ORG Middle I-ORG and I-ORG Youth I-ORG Medical I-ORG High-end I-ORG Talent I-ORG Studio I-ORG Project I-ORG Yu O Wei I-AWARD 2018 I-AWARD No. I-AWARD 2). O This O work O was O supported O by O Diabetes B-ORG UK I-ORG MSM-G O no. O 12/0004508 B-AWARD the O British B-ORG Heart I-ORG Foundation I-ORG SEO O no. O FS/09/029/27902 B-AWARD and O the O UK O Medical B-ORG Research I-ORG Council I-ORG SEO O no. O MC_UU_12012/4 B-AWARD This O research O was O supported O by O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Xinjiang I-ORG province I-ORG 2018B01006–4 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31770451 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2016YFC0501400 O and O ABLife O O ABL2014–02028 O This O project O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No.81472870 B-AWARD the O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG CIFMS O No. O 2016-I2M-1-002 O and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFC0901501 O The O design O data O collection O and O cellular O experiments O were O supported O by O National B-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG of I-ORG China I-ORG 81702949 O the O histological O experiments O and O data O analysis O were O supported O by O Natural B-ORG Sciences I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG 2018JJ3851 O the O bioinformatics O analysis O data O interpretation O and O writing O of O this O manuscript O were O supported O by O the O Youth B-ORG research I-ORG fund I-ORG of I-ORG Xiangya I-ORG Hospital I-ORG 2016Q07 O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 11904012 O the O National B-ORG Postdoctoral I-ORG Program I-ORG for I-ORG Innovative I-ORG Talents I-ORG BX20180014 O and O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2019M660284 O The O present O study O was O supported O by O several O grants O named O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81671309 B-AWARD and O 81971229 B-AWARD the B-ORG Tibet I-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG Tibet I-ORG grant O no. O XZ2017ZR-ZY026 B-AWARD and O the B-ORG Postgraduate I-ORG Research I-ORG and I-ORG Innovation I-ORG Project I-ORG of I-ORG Chongqing I-ORG Grant O No. O CYS17148 B-AWARD respectively O This O study O was O funded O by O the B-ORG Pearl I-ORG River I-ORG S&T I-ORG Nova I-ORG Programme I-ORG of I-ORG Guangzhou I-ORG No: O 201710010086 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No: O 81602199 B-AWARD the O Guangzhou B-ORG Science I-ORG Technology I-ORG and I-ORG Innovation I-ORG Commission I-ORG No: O 201607010395 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O China O No: O 2016A030313496 B-AWARD and O National O Natural O Science O Foundation O of O China O No: O 81602199 O The O funding O body O has O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O The O authors O would O like O to O acknowledge O funding O from O European B-ORG Research I-ORG Council I-ORG ERC O Starting O and O Proof O of O Concept O Grant O 336882 O I-AWARD 825905 O Science B-ORG Foundation I-ORG Ireland I-ORG SFI O Support O Grant O SFI O 13/ERC/L2864 B-AWARD and O Interreg B-ORG 2Seas B-AWARD 3DMed I-AWARD This O work O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 61503082 B-AWARD and O 61403121 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG No. O 2016J05145 B-AWARD the O National O Key O R&D O Program O of O China O No. O 2018YFC0407101 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 2019B22314 B-AWARD the O Program O for O New O Century O Excellent O Talents O in O Fujian O Province O University O No. O GY-Z18155 O the O Program O for O Outstanding O Young O Scientific O Researcher O in O Fujian O Province O University O No. O GY-Z160149 O and O the O Scientific O Research O Foundation O of O Fujian O University O of O Technology O Nos O GY-Z17162 O and O GY-Z15007 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81873076 O the O Shanghai B-ORG Talents I-ORG Development I-ORG Fund I-ORG Project I-ORG in I-ORG China I-ORG 2017090 O and O the O Innovation B-ORG Project I-ORG for I-ORG Undergraduates I-ORG of I-ORG Shanghai I-ORG University I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG 2019SHUTCM187 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG RF, O no. O 31572510 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG grant O no. O 2017CFA020 B-AWARD and O the O Da B-ORG Bei I-ORG Nong I-ORG Group I-ORG Promoted I-ORG Project I-ORG for I-ORG Young I-ORG Scholar I-ORG of I-ORG HZAU I-ORG grant O no. O 2017DBN001 B-AWARD This O work O was O funded O by O grants O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0500800 O the O Sichuan-International B-ORG joint I-ORG research I-ORG for I-ORG science I-ORG and I-ORG technology I-ORG 2018HH0098 O China B-ORG Agricultural I-ORG Research I-ORG System I-ORG CARS-42-17 O the O Integration B-ORG and I-ORG Demonstration I-ORG of I-ORG Key I-ORG Technologies I-ORG for I-ORG Goose I-ORG Industrial I-ORG Chain I-ORG in I-ORG Sichuan I-ORG Province I-ORG 2018NZ0005 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 42090011 B-AWARD 62171329 B-AWARD National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2022YFB3902800 O Wuhan B-ORG Knowledge I-ORG Innovation I-ORG Special I-ORG Project I-ORG Grant O No. O 2022010801010351 B-AWARD and O Science B-ORG Foundation I-ORG Project I-ORG of I-ORG Wuhan I-ORG Institute I-ORG of I-ORG Technology I-ORG Grant O No. O K2021021 B-AWARD This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81872362 B-AWARD and O 81672842 B-AWARD the O Taishan B-ORG Scholars I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG Grant O No. O ts201511096 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2017ZC0227 O This O research O was O supported O by O the O Spanish B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Innovation I-ORG PSI2013-42626-P O AGAUR B-ORG Generalitat I-ORG de I-ORG Catalunya I-ORG 2014SGR856 O and O the O European B-ORG Research I-ORG Council I-ORG StG-2010 O 263145 O The O work O was O supported O by O the O Open B-ORG Fund I-ORG of I-ORG Key I-ORG Laboratory I-ORG of I-ORG Advanced I-ORG Engineering I-ORG Materials I-ORG Structure I-ORG Behavior I-ORG and I-ORG Functional I-ORG Control I-ORG of I-ORG the I-ORG University I-ORG of I-ORG Hunan I-ORG Province I-ORG Changsha O University O of O Science O O Technology O Grant O No. O 10KA10 B-AWARD the O Innovation B-ORG Fund I-ORG of I-ORG Characteristic I-ORG Advantage I-ORG Key I-ORG Discipline I-ORG of I-ORG Civil I-ORG Engineering I-ORG of I-ORG Changsha I-ORG University I-ORG of I-ORG Science I-ORG I-ORG Technology I-ORG Grant O No. O 17ZDXK07 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG Grant O No. O 2022JJ30600 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Changsha I-ORG Grant O No. O kq2202208 B-AWARD the O Open B-ORG Fund I-ORG of I-ORG Scientific I-ORG Research I-ORG and I-ORG Innovation I-ORG Platform I-ORG of I-ORG the I-ORG Education I-ORG Department I-ORG of I-ORG Hunan I-ORG Province I-ORG Grant O No. O 20K005 B-AWARD the O Open B-ORG Fund I-ORG of I-ORG National I-ORG Engineering I-ORG Research I-ORG Center I-ORG of I-ORG Highway I-ORG Maintenance I-ORG Technology I-ORG Changsha O University O of O Science O O Technology O Grant O No. O kfj210102 B-AWARD This O research O was O funded O by O Science B-ORG Foundation I-ORG Ireland I-ORG Strategic O Research O Cluster O grant O number O 09/SRC/B1794 B-AWARD The O Genomics O and O Screening O Core O facility O at O the O National O University O of O Ireland O Galway O is O funded O by O NUIG O and O the O Irish O Government’s O Programme O for O Research O in O Third O Level O Institutions O Cycles O 4 O and O 5, O National O Development O Plan O 2007-2013 O This O research O was O partly O funded O by O the O Marine B-ORG Institute I-ORG under O the O Marine O Research O Program O by O the O Irish O Government O grant O number O PBA/MB/16/01.The B-AWARD APC O was O funded O by O Irish B-ORG Research I-ORG Council I-ORG through O Postgraduate O Scholarship O GOIPG/2016/1113 B-AWARD This O research O was O funded O by O open O access O funding O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grants O no. O 31360519 B-AWARD and O 32060342 B-AWARD Guizhou B-ORG Normal I-ORG University I-ORG Academic I-ORG New I-ORG Seedling I-ORG Fun I-ORG grant O no. O QSXM B-AWARD 2021]A13 O and O Karst B-ORG Mountain I-ORG Ecological I-ORG Security I-ORG Engineering I-ORG Research I-ORG Center I-ORG grant O no. O KY B-AWARD 2021]007 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81930073 O and O 81772466 B-AWARD Shanghai B-ORG Shenkang I-ORG Hospital I-ORG Development I-ORG Center I-ORG City I-ORG Hospital I-ORG Emerging I-ORG Cutting-edge I-ORG Technology I-ORG Joint I-ORG Research I-ORG Project I-ORG SHDC12017102 O and O Shanghai B-ORG Municipal I-ORG Health I-ORG Commission I-ORG Key I-ORG Discipline I-ORG Project I-ORG 2017ZZ02025 O and O 2017ZZ01019 B-AWARD This O work O was O supported O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG R21 O HD I-AWARD 073880 I-AWARD to O Prof O Satish O C O Kalhan O Indian B-ORG Council I-ORG of I-ORG Medical I-ORG Research I-ORG New I-ORG Delhi I-ORG 58/1/8/MRC-ICMR/2009/NCD-II O to O Prof O Chittaranjan O S O Yajnik O Medical B-ORG Research I-ORG Council I-ORG UK I-ORG MR/J000094/1 O to O Prof O Chittaranjan O S O Yajnik O European B-ORG Union I-ORG HEALTH I-ORG F2-2011-278917 O to O Prof O Chittaranjan O S O Yajnik O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31360258 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2016A020215036 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2015A030313047 B-AWARD No. O 2015A030313077 B-AWARD No. O 2019A1515011184 B-AWARD and O No. O 2020A1515010012 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO. O 82273695 B-AWARD NO. O 82002147 B-AWARD and O NO. O 82073618 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG NO. O 2019M662543 B-AWARD Key B-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG Henan I-ORG Institution I-ORG of I-ORG Higher I-ORG Education I-ORG NO. O 21A310026 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National O Nature O Science O Foundation O of O China O The O molecular I-ORG mechanisms I-ORG of I-ORG Glypican3-Wnt I-ORG signal I-ORG pathways I-ORG mediated I-ORG airway I-ORG local I-ORG inflammation I-ORG in I-ORG acute I-ORG lung I-ORG injury O Award O Number O 81600062 B-AWARD Dialogue B-ORG between I-ORG the I-ORG immediate I-ORG early I-ORG protein I-ORG Cyr61/CCN1 I-ORG with I-ORG PI3K I-ORG signaling I-ORG regulates I-ORG the I-ORG development I-ORG of I-ORG acute I-ORG lung I-ORG injury O Award O Number O 81270131 B-AWARD and O Wenzhou O Science O Technology O Department O Foundation O The O role I-ORG and I-ORG mechanism I-ORG of I-ORG GPC3 I-ORG in I-ORG acute I-ORG lung I-ORG injury O Award O Number O Y20150129 B-AWARD This O study O was O funded O by O the O Economic B-ORG and I-ORG Social I-ORG Research I-ORG Council I-ORG Secondary I-ORG Data I-ORG Analysis I-ORG Initiative I-ORG 300405-01 O All O authors O received O funding O from O the O Medical B-ORG Research I-ORG Council I-ORG MC_UU_12017/13 O and O MC_UU_12017/15 B-AWARD and O Scottish B-ORG Government I-ORG Chief I-ORG Scientist I-ORG Office I-ORG SPSHU13 O and O SPHSU15 B-AWARD SVK O is O funded O by O an O NRS B-ORG Senior I-ORG Clinical I-ORG Fellowship I-ORG SCAF/15/02 O This O research O was O funded O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China O grant O number O 2020YFC2008602 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 72174212 B-AWARD and O the O Central B-ORG South I-ORG University I-ORG Innovation-driven I-ORG project O grant O number O CX20220336 B-AWARD This O work O was O supported O by O aChest O Heart I-ORG I-ORG Stroke I-ORG Scotlandproject O grant O award O R11/A136 O D.C O is O supported O by O aBritish O Heart I-ORG Foundation I-ORG BHF I-ORG Clinical I-ORG Research I-ORG Training I-ORG Fellowship[FS/14/15/30661 O B.H O is O supported O by O aBHFproject O grant O PG/14/97/31263 O P.McC O is O supported O by O aNational O Institute I-ORG for I-ORG Health I-ORG Research I-ORG NIHR I-ORG Efficacy I-ORG and I-ORG Mechanism I-ORG Evaluation I-ORG Programme(12/170/45 O C.B O is O supported O by O aBHF O Centre I-ORG of I-ORG Research I-ORG Excellence I-ORG Award(RE/13/5/30177 O The O majority O of O lab O and O data O analysis O was O funded O by O the O National B-ORG Science I-ORG Foundation I-ORG Doctoral O Dissertation O Improvement O Grant O 1433043 O to O AES O and O KFE O Website:http://www.nsf.gov O Funding O for O the O lab O analysis O was O also O supported O in O part O by O the O Sigma B-ORG Xi I-ORG Scientific O Research O Society O grant O G20141015712606 O to O AES O Website:https://www.sigmaxi.org/programs/grants-in-aid O Sample O collection O and O analysis O of O the O Yucatan O samples O was O supported O by O the O Swiss B-ORG National I-ORG Science I-ORG Foundation I-ORG grant O O PBEZ2—104322 B-AWARD to O AG O Website:http://www.snf.ch/en/Pages/default.aspx O Original O sample O collection O was O funded O by O research O awards O from O the O College O of O Liberal O Arts O and O Sciences O at O the O University O of O Florida O to O DAH O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O study O was O supported O by O the B-ORG High-level I-ORG hospital I-ORG foster I-ORG grants I-ORG from I-ORG Fujian I-ORG Provincial I-ORG Hospital I-ORG 2019HSJJ13 O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG of I-ORG Fujian I-ORG Province I-ORG 2018J06020 O Education B-ORG and I-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG 2060402 O Joint B-ORG Funds I-ORG for I-ORG the I-ORG innovation I-ORG of I-ORG science I-ORG and I-ORG technology I-ORG Fujian I-ORG Province I-ORG 2018Y9098 O 2018Y9013 O Fujian B-ORG Provincial I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Research I-ORG Medical I-ORG Innovation I-ORG Project I-ORG 2019-cx-3 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81772560 O 81702438 O Youth B-ORG Project I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Provincial I-ORG Health I-ORG Commission I-ORG 2018-1-10 O Fujian O Provincial O Health O and O Family O Planning O Research O Talents O Cultivation O Project O 2017-ZQN-27 O This O research O was O funded O by O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Projects I-ORG of I-ORG Shaanxi I-ORG Province I-ORG of I-ORG China I-ORG grant O number O 2020ZDLGY14-10 B-AWARD the O Postdoctoral B-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG of I-ORG China I-ORG grant O number O 2018BSHYDZZ06 B-AWARD and O the O Special B-ORG Fund I-ORG for I-ORG Technology I-ORG Innovation I-ORG Guidance I-ORG of I-ORG Shaanxi I-ORG Province I-ORG of I-ORG China I-ORG grant O number O 2019CGXNG-016 B-AWARD This O study O was O supported O by O the O following O Grant O sponsors O CNPq B-ORG 402008/2010-3 B-AWARD and O 590148/2011-7 B-AWARD CAPES B-ORG 3300017023p6 B-AWARD Fapesp B-ORG 2015/22145-6 B-AWARD This O research O was O funded O in O part O through O the O USDA O Agricultural B-ORG Research I-ORG Service I-ORG Agreements O 58-6066-6-046 B-AWARD and O 58-6066-6-059 B-AWARD USDA O National B-ORG Institute I-ORG of I-ORG Food I-ORG and I-ORG Agriculture I-ORG Multi-State O Hatch O project O 17810 B-AWARD and O National B-ORG Science I-ORG Foundation I-ORG grant O DBI-1659630 B-AWARD Any O mention O of O trade O names O or O commercial O products O is O solely O for O the O purpose O of O providing O specific O information O and O does O not O imply O recommendation O or O endorsement O by O the O USDA O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81400199 B-AWARD and O No. O 30972696 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20150321 O and O Suzhou B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG China I-ORG No. O SYS201414 B-AWARD and O No. O SYS201540 B-AWARD This O research O was O supported O by O the O Research B-ORG Council I-ORG Advanced I-ORG Laureate I-ORG Award I-ORG EVIC I-ORG to O LOD O IRCLA/2019/49 O Trinity B-ORG College I-ORG Dublin I-ORG Dean’s I-ORG Research I-ORG Award O grant O number O 9050610-1106-000000 B-AWARD to O A.M O and O Horizon B-ORG 2020 I-ORG Research I-ORG and I-ORG Innovation I-ORG Award I-ORG EVPRO I-ORG to O LOD O 814495 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 71774130 B-AWARD Shaanxi B-ORG Science I-ORG and I-ORG Technology I-ORG Association O grant O number O 2022KRW23 B-AWARD and O China B-ORG Huaneng I-ORG Group O grant O number O HNKJ20-H87 B-AWARD This O work O was O supported O in O part O by O National B-ORG Institutes I-ORG of I-ORG Health I-ORG grants O R01HL103931 O P20HL113452 B-AWARD R01DK106000 B-AWARD R01HL126827 B-AWARD R01HL137004 B-AWARD R01HL105649 B-AWARD Core O Utilization O Pilot O funding O made O possible O by O the O Clinical O and O Translational O Science O Collaborative O of O Cleveland O UL1TR000439 O American B-ORG Heart I-ORG Association I-ORG Scientist O Development O Grant O 14SDG18650010 O American O Society O of O Nephrology O Predoctoral O Fellowship O the O David O and O Helen O Boone O Foundation O Research O Fund O the O University O of O Toledo O Women O and O Philanthropy O Genetic O Analysis O Instrumentation O Center O Russian B-ORG Science I-ORG Foundation I-ORG 18-15-00222 O and O the O Intramural O Research O Program O National O Institute O on O Aging O National O Institutes O of O Health O This O work O was O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG Sri I-ORG Lanka I-ORG OSTP/2017/67 O NSF/SCH/2017/07 B-AWARD RG/2011/BT/05 B-AWARD RG/2006/AG/08 B-AWARD the O National B-ORG Research I-ORG Council I-ORG of I-ORG Sri I-ORG Lanka I-ORG NRC-05-10 O and O the O Agriculture B-ORG and I-ORG Food I-ORG Research I-ORG Initiative I-ORG AFRI I-ORG program I-ORG from I-ORG the I-ORG US I-ORG Department I-ORG of I-ORG Agriculture I-ORG National I-ORG Institute I-ORG of I-ORG Food I-ORG and I-ORG Agriculture I-ORG 2018-67013-27820 O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81772506 O 81530072 B-AWARD 81972203 B-AWARD 81802321 B-AWARD the O funds O from O Shanghai B-ORG Shenkang I-ORG Center I-ORG SHDC12018121 O and O Shanghai B-ORG Municipal I-ORG Education I-ORG Commission–Gaofeng I-ORG Clinical I-ORG Medicine I-ORG Grant O Support O No. O 20152210 O This O work O was O sponsored O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Project O No. O 41703108 B-AWARD Science B-ORG I-ORG Technology I-ORG Project I-ORG of I-ORG Education I-ORG Department I-ORG Hubei I-ORG Province I-ORG China I-ORG No. O D20161301 B-AWARD Training B-ORG Program I-ORG of I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG for I-ORG Undergraduates I-ORG of I-ORG Yangtze I-ORG University I-ORG Yz2020380 O Yz2020385 B-AWARD and O Open B-ORG Fund I-ORG of I-ORG Key I-ORG Labo I-ORG ratory I-ORG of I-ORG Exploration I-ORG Technologies I-ORG for I-ORG Oil I-ORG and I-ORG Gas I-ORG Resources I-ORG Yangtze I-ORG University I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG No. O K2021-14 B-AWARD to O Professor O Li-Mei O Cai O This O study O was O supported O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Number O 81900768 B-AWARD Young B-ORG Talent I-ORG Development I-ORG Plan I-ORG of I-ORG Changzhou I-ORG Health I-ORG Commission I-ORG Grant O Number O CZQM2020007 B-AWARD Changzhou B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG Grant O Number O CE20205022 B-AWARD and O Yong B-ORG Talent I-ORG Project I-ORG of I-ORG Changzhou I-ORG Health I-ORG Commission I-ORG Grant O Number O QN201908 B-AWARD This O work O was O supported O by O grants O from O the B-ORG Priority I-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O JX10231801 B-AWARD The B-ORG Innovation I-ORG Capability I-ORG Development I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O BM2015004 B-AWARD and O Jiangsu B-ORG Biobank I-ORG of I-ORG Clinical I-ORG Resources O BM2015004 O This O research O was O funded O by O Open B-ORG Project I-ORG Funding I-ORG of I-ORG the I-ORG Key I-ORG Laboratory I-ORG of I-ORG Fermentation I-ORG Engineering I-ORG Ministry O of O Education O grant O No. O 202209EF09 B-AWARD to O C.Y O by O the O Key B-ORG R&D I-ORG Project I-ORG of I-ORG Hubei I-ORG Province I-ORG Social O Development O grant O No. O 2022BCA018 B-AWARD to O K.H O and O by O the O Hubei B-ORG Province I-ORG Natural I-ORG Science I-ORG Foundation O grant O No. O 2021CFB289 B-AWARD to O H.L O The O APC O was O funded O by O grant O No. O 2022BCA018 O This O work O was O supported O by O DOE O Great B-ORG Lakes I-ORG Bioenergy I-ORG Research I-ORG Center I-ORG DOE O BER O Office O of O Science O DE-SC0018409 B-AWARD to O J.H.I O The O 2023 O Fellowship O Program O project O no. O PJ01661001 B-AWARD of O the O National B-ORG Institute I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG Rural I-ORG Development I-ORG Administration I-ORG to O S.S O Cooperative O Research O Program O for O Agriculture O Science O and O Technology O Development O Project O no. O PJ01486501 B-AWARD of O Rural O Development O Administration O to O S.L.K O H.L O was O supported O by O the O Korea O Polar O Research O Institute O KOPRI O grant O funded O by O the O Ministry B-ORG of I-ORG Oceans I-ORG and I-ORG Fisheries I-ORG Project O no. O KOPRI B-AWARD PE23130 O Luzhou B-ORG Municipal I-ORG Government-Southwest I-ORG Medical I-ORG University I-ORG Science I-ORG and I-ORG Technology I-ORG Strategic I-ORG Cooperation I-ORG Project I-ORG in I-ORG 2018 I-ORG 2018LZXNYD-ZK43 O Luzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Seedling I-ORG Cultivation I-ORG Project I-ORG in I-ORG 2018 I-ORG 2018-RCM-72 O and O Academician B-ORG Workstation I-ORG Construction I-ORG Project I-ORG of I-ORG Luzhou I-ORG 20180101 O This O work O was O supported O by O grants O from O National B-ORG Science I-ORG Council I-ORG NSC104-2314-B-002-185-MY2 O 101-2325-B-002-064 I-AWARD 102-2325-B-002-087 I-AWARD 103-2325-B-002-027 I-AWARD 104-2325-B-002-035 I-AWARD 105-2325-B-002-030 I-AWARD 104-2314-B-567-002 I-AWARD 105-2314-B-567-001 O Cardinal B-ORG Tien I-ORG Hospital I-ORG CTH107A-2A23 O and O from O National B-ORG Health I-ORG Research I-ORG Institutes I-ORG intramural O funding O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 41306138 B-AWARD the O Key B-ORG Laboratory I-ORG of I-ORG Mariculture I-ORG and I-ORG Stock I-ORG Enhancement I-ORG in I-ORG North I-ORG China’s I-ORG Sea I-ORG Ministry I-ORG of I-ORG Agriculture I-ORG and I-ORG Rural I-ORG Affairs I-ORG P. I-ORG R. I-ORG China I-ORG 2018-KF-15 O and O the O Liaoning B-ORG Scientific I-ORG Instrument I-ORG Sharing I-ORG Platform I-ORG L201810 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31100490 O the O Special O Fund O for O Nonprofit B-ORG Research I-ORG Institute I-ORG in I-ORG Central I-ORG Government I-ORG CAFYBB2012040 O CAFYBB2014ZX001-3 B-AWARD and O the O Lecture B-ORG and I-ORG Study I-ORG Program I-ORG for O Outstanding O Scholars O from O Home O and O Abroad O CAFYBB2011007 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O No. O 11705137 O Natural O Science O Fundamental O Research O Plan O of O Shaanxi O Province O grant O number O No. O 2018JQ1015 O NSAF B-ORG Joint I-ORG Fund I-ORG grant O number O No. O U1830124 O and O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG grant O number O No. O 2018T111053 O This O research O was O funded O by O the O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Development I-ORG Plan I-ORG of I-ORG Yantai I-ORG 2020MSGY114 O Yantai B-ORG “Double I-ORG Hundred I-ORG Plan” I-ORG and I-ORG by I-ORG the I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Laboratory I-ORG of I-ORG Molecule-Based I-ORG Materials I-ORG fzj22022 O The B-ORG Graduate I-ORG Innovation I-ORG Foundation I-ORG of I-ORG Yantai I-ORG University I-ORG KGIFYTU2223 O is O gratefully O acknowledged O for O Z. O Wang O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31601036 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG 2021CFB190 O Scientific B-ORG research I-ORG plan I-ORG project I-ORG of I-ORG Hubei I-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG Q20201314 O B2017038 O and O Innovation O and O Entrepreneurship O Training O Program O for O College O Students O of O Yangtze O University O Yz2022232 O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31370779 O 31401027 B-AWARD the B-ORG Taishan I-ORG Scholar I-ORG Construction I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG 6631114314 O the B-ORG Project I-ORG of I-ORG Shandong I-ORG Province I-ORG Higher I-ORG Educational I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG J15LE15 O J16LE04 B-AWARD the B-ORG Open I-ORG Fund I-ORG of I-ORG Laboratory I-ORG for I-ORG Marine I-ORG Biology I-ORG and I-ORG Biotechnology I-ORG Qingdao I-ORG National I-ORG Laboratory I-ORG for I-ORG Marine I-ORG Science I-ORG and I-ORG Technology I-ORG Qingdao I-ORG China I-ORG No.OF2015NO19 O and O Research B-ORG Foundation I-ORG for I-ORG Advanced I-ORG Talents I-ORG of I-ORG Qingdao I-ORG Agricultural I-ORG University I-ORG 6631114335 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81671423 B-AWARD and O No. O 81402130 B-AWARD the O Fok B-ORG Ying I-ORG Tung I-ORG Education I-ORG Foundation I-ORG No. O 151039 B-AWARD Liaoning B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 201602864 O and O Distinguished B-ORG Talent I-ORG Program I-ORG of I-ORG Shengjing I-ORG Hospital I-ORG No. O ME76 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG People’s I-ORG Republic I-ORG of I-ORG China I-ORG No. O 81570134 B-AWARD National B-ORG Public I-ORG Health I-ORG Grand I-ORG Research I-ORG Foundation I-ORG No. O 201202017 B-AWARD A B-ORG Project I-ORG Funded I-ORG by I-ORG the I-ORG Priority I-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institute I-ORG No. O JX10231801 B-AWARD and O Key B-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Health I-ORG Agency I-ORG No. O K201107 B-AWARD The O funding O body O have O no O impact O on O design O of O the O study O and O data O acquisition O analysis O and O interpretation O of O data O and O compilation O of O the O manuscript O This O research O was O funded O by O the O Heart B-ORG and I-ORG Stroke I-ORG Foundation I-ORG of I-ORG Canada I-ORG Grant O PJT-156181 B-AWARD the O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG Grant O CPG-158259 B-AWARD and O the O Natural B-ORG Sciences I-ORG and I-ORG Engineering I-ORG Research I-ORG Council I-ORG of I-ORG Canada I-ORG Grant O CHRP B-AWARD 523528-18 O Supported O by O AEI-Ministerio B-ORG de I-ORG Ciencia I-ORG e I-ORG Innovación I-ORG Spain I-ORG Grant O PID2019-105713GB-I00/AEI/10.13039/501100011033 B-AWARD and O Conselleria B-ORG d’Educació I-ORG Cultura I-ORG i I-ORG Esports I-ORG Generalitat I-ORG Valenciana I-ORG Spain I-ORG Grant O PROMETEO/2020/071 B-AWARD C.M.S-L O is O the O recipient O of O a O predoctoral O fellowship O PRE2020-092458 O funded O by O AEI/10.13039/501100011033 O Part O of O “Red O Traslacional O para O la O Aplicación O Clínica O de O Vesículas O Extracelulares O Tentacles O RED2018-102411-T O Agencia B-ORG Estatal I-ORG de I-ORG Investigación I-ORG Spain I-ORG This O work O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81202324 B-AWARD to O XZ, O and O No. O 81672675 B-AWARD to O JinL O the O Excellent B-ORG Young I-ORG Scientist I-ORG Foundation I-ORG of I-ORG Sichuan I-ORG University I-ORG 2017SCU04A16 O to O XZ O and O the O Open B-ORG Foundation I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Oral I-ORG Diseases I-ORG Sichuan I-ORG University I-ORG SKLOD201714 O to O JinL O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81803452 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O BK20211114 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG in I-ORG Colleges I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O 21KJB350016 B-AWARD and O the O National B-ORG Subject I-ORG Cultivation I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Vocational I-ORG College I-ORG of I-ORG Medicine I-ORG No. O 20204304 B-AWARD And O The O APC O was O funded O by O Natural O Science O Foundation O of O Jiangsu O Province O No. O BK20211114 O We O acknowledge O Graham O Taylor O and O Charles O Bangham O both O from O Imperial O College O London O UK, O for O provision O of O MT-2 O cells O and O input O towards O our O secondary O antibody O optimisation O respectively O and O David O Brighty O University O of O Dundee O for O helpful O discussions O This O work O was O funded O by O aUniversity O of I-ORG York I-ORG Department I-ORG of I-ORG Biology I-ORG summer I-ORG studentshipgrant O awarded O to O JF O M0225901 O and O part O funded O byThe O Wellcome I-ORG Trust I-ORG Value I-ORG in I-ORG Peopleaward O to O JF O reference O 092430/Z/10/Z B-AWARD and O aUniversity O of I-ORG York/Hull I-ORG York I-ORG Medical I-ORG Schoolpump-priming O award O to O FM O M0227004 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 8197110786 B-AWARD 81773256 B-AWARD 81572982 B-AWARD 81372442 B-AWARD and O 81172164 B-AWARD the O Sci-Tech B-ORG Key I-ORG Program I-ORG of I-ORG the I-ORG Guangzhou I-ORG City I-ORG Science I-ORG Foundation I-ORG Grant O No. O 201802020001 B-AWARD the O Guangdong B-ORG Province I-ORG Natural I-ORG Science I-ORG Foundation I-ORG grant O no. O 2018A030310260 B-AWARD This O research O was O funded O by O the O National O Key O R&D O Program O of O China O 2016YFB1200505 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51905555 O 11902366 O the O Hu-Xiang B-ORG Youth I-ORG Talent I-ORG Program I-ORG No. O 2018RS3002 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG 2019JJ50810 O and O the O Innovation-Driven O Project O of O Central O South O University O 2019CX017 O This O work O was O partially O supported O by O the O Key O Research B-ORG Project I-ORG on I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG Culture I-ORG and I-ORG Management I-ORG of I-ORG Henan I-ORG No. O TCM2021013 B-AWARD the B-ORG Major I-ORG Increase I-ORG or I-ORG Decrease I-ORG Branch I-ORG Program I-ORG of I-ORG Central I-ORG level I-ORG No. O 2060302-1904-24 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 82104035 B-AWARD the B-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG Teams I-ORG of I-ORG Colleges I-ORG and I-ORG Universities I-ORG in I-ORG Henan I-ORG Province I-ORG No. O 23IRTSTHN028 B-AWARD and O the O Provincial B-ORG Key I-ORG Technologies I-ORG R&D I-ORG Program I-ORG of I-ORG Henan I-ORG Province I-ORG No. O 221100310400 B-AWARD M.L O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81601494 O and O PUMC B-ORG Youth I-ORG Fund/the O Fundamental O Research O Funds O for O the O Central O Universities O 3332016030 O L.Z O was O supported O by O PUMC O Youth O Fund/the O Fundamental O Research O Funds O for O the O Central O Universities O 2017320017 O N.W O was O supported O by O National B-ORG key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC1308700 O The O funding O source O had O no O involvement O in O study O design O interpretation O of O data O and O in O the O writing O of O the O article O This O work O was O supported O by O theBritish O Heart I-ORG Foundation[PG/12/39/29626 O and O PG/15/111/31939 B-AWARD andBiotechnology O and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council[BB/C517041/1 O theBritish O Heart I-ORG Foundation I-ORG Centre I-ORG of I-ORG Regenerative I-ORG Medicine[RM/13/3/30159 O theBritish O Heart I-ORG Foundation I-ORG Centre I-ORG of I-ORG Research I-ORG Excellence[RE/13/1/30181 O and O theERC[715895 O I-AWARD CAVEHEART O This O work O is O supported O by O the O programs O of O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFB1000603 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 61502336 O the O Key B-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Tianjin I-ORG 16YFZCGX00210 O and O the O open O funding O project O of O Key B-ORG Laboratory I-ORG of I-ORG Computer I-ORG Network I-ORG and I-ORG Information I-ORG Integration I-ORG Southeast I-ORG University I-ORG Ministry I-ORG of I-ORG Education I-ORG K93-9-2016-05 O Xiaowang O Zhang O is O supported O by O Tianjin O Thousand O Young O Talents O Program O and O the O project O is O sponsored O by O School O of O Computer O Science O and O Technology O in O Tianjin O University O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O author O has O received O funding O from O Merck B-ORG Sharp I-ORG I-ORG Dohme I-ORG Corp I-ORG ClinicalTrials.gov O Identifier O NCT01656434 B-AWARD Repros B-ORG Therapeutics I-ORG Inc O ClinicalTrials.gov O Identifier O NCT01728454 B-AWARD AbbVie B-ORG ClinicalTrials.gov O Identifier O NCT01931670 B-AWARD and O Myovant B-ORG Sciences I-ORG GmbH I-ORG ClinicalTrials.gov O Identifier O NCT03204318 B-AWARD This O work O was O supported O by O the O Earmarked B-ORG Fund I-ORG for I-ORG the I-ORG Modern I-ORG Agro-Industry I-ORG Technology I-ORG Research I-ORG System I-ORG No. O CARS-34 B-AWARD the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG 973 I-ORG program I-ORG in I-ORG China I-ORG No. O 2014CB138705 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 31372363 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O number O 31260339 B-AWARD Germplasm B-ORG resource I-ORG innovation I-ORG project I-ORG of I-ORG Bingtuan I-ORG Grant O number O 2012BB050 B-AWARD and O Distinguished B-ORG Youth I-ORG innovation I-ORG foundation I-ORG of I-ORG Bingtuan I-ORG Grant O number O 2014CD003 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O 2004 O birth O cohort O study O is O supported O by O the O Wellcome B-ORG Trust I-ORG through O the O scheme O called O ‘Major O Awards O for O Latin O America O on O Health O Consequences O of O Population O Change’ O Grant O number O 086974/Z/08/Z B-AWARD The O World B-ORG Health I-ORG Organization I-ORG Grant O number O 03014HNI B-AWARD Brazilian B-ORG National I-ORG Research I-ORG Council I-ORG CNPq I-ORG Grant O numbers O 481012-2009-5 B-AWARD 484077-2010-4 B-AWARD 470965-2010-0 B-AWARD and O 481141-2007-3 B-AWARD and O Brazilian B-ORG Ministry I-ORG of I-ORG Health I-ORG Grant O number O 25000.105293/2004-83 B-AWARD have O supported O the O previous O phase O of O the O study O LPS O was O supported O by O ‘Science O without O Borders’ O Brazilian O scheme O under O the O protocol O number O 201801/2014-0 B-AWARD This O research O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Chongqing I-ORG China I-ORG CSTB2022NSCQ-MSX0110 O the O Science B-ORG and I-ORG Technology I-ORG Research I-ORG Program I-ORG of I-ORG Chongqing I-ORG Municipal I-ORG Education I-ORG Commission I-ORG KJQN202000421 O and O the O Program B-ORG for I-ORG Youth I-ORG Innovation I-ORG in I-ORG Future I-ORG Medicine I-ORG Chongqing I-ORG Medical I-ORG University I-ORG W0046 O This O study O was O funded O by O Research B-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG No. O 16070502900 B-AWARD The B-ORG Innovation I-ORG Team I-ORG Program I-ORG of I-ORG Shanghai I-ORG Normal I-ORG University I-ORG No. O A-7001-15-001005 B-AWARD and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG No. O 18ZR1428000 B-AWARD This O research O was O financially O supported O by O the O Fund O of O Project B-ORG of I-ORG Inheritance I-ORG Studio I-ORG of I-ORG National I-ORG Famous I-ORG Experts I-ORG of I-ORG State I-ORG Administration I-ORG of I-ORG TCM I-ORG no. O 2019 B-AWARD 41 O the O First B-ORG Batch I-ORG of I-ORG Key I-ORG Projects I-ORG of I-ORG TCM I-ORG Discipline I-ORG Construction I-ORG in I-ORG Sichuan I-ORG Province I-ORG Pharmaceutical I-ORG Botany I-ORG no. O 2020 B-AWARD 84 O “XingLin B-ORG Scholars” I-ORG Research I-ORG Promotion I-ORG Plan I-ORG of I-ORG Chengdu I-ORG University I-ORG of I-ORG TCM I-ORG no. O QJRC2022017 B-AWARD This O work O was O supported O by O the O Australian B-ORG Research I-ORG Council I-ORG Center I-ORG of I-ORG Excellence I-ORG for I-ORG Integrative I-ORG Brain I-ORG Function I-ORG ARC O Center O of O Excellence O Grant O CE140100007 B-AWARD the O Australian B-ORG Research I-ORG Council I-ORG Laureate I-ORG Fellowship I-ORG Grant I-ORG FL140100025 B-AWARD and O the O Australian B-ORG Research I-ORG Council I-ORG Discovery I-ORG Project I-ORG Grant I-ORG DP170101778 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the B-ORG Open I-ORG Fund I-ORG of I-ORG Cultivation I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Qinba I-ORG Biological I-ORG Resources I-ORG and I-ORG Ecological I-ORG Environment I-ORG of I-ORG Shaanxi I-ORG University I-ORG of I-ORG Technology I-ORG China I-ORG SLGPT2019KF04-02 O Scientific B-ORG research I-ORG project I-ORG of I-ORG City-University I-ORG co-construction I-ORG of I-ORG Shaanxi I-ORG Province I-ORG China I-ORG SXZJ-2301 O SXJ-2101 B-AWARD Qinba B-ORG Bioremediation I-ORG and I-ORG Resource I-ORG Development I-ORG Research I-ORG and I-ORG Innovation I-ORG Base I-ORG 2022-ZC-GXYZ-0029 O and O the B-ORG project I-ORG of I-ORG Foreign I-ORG Experts I-ORG Bureau I-ORG of I-ORG Shaanxi I-ORG province I-ORG of I-ORG China I-ORG China I-ORG G2022040018L O 2022WGZJ-20 B-AWARD G2021041011L B-AWARD G20200241015 B-AWARD The B-ORG General I-ORG Program I-ORG from I-ORG the I-ORG Education I-ORG Department I-ORG of I-ORG Liaoning I-ORG Province I-ORG LJKMZ20220595 O The B-ORG Scientific I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Innovation I-ORG Team I-ORG Construction I-ORG Plan I-ORG of I-ORG Shenyang I-ORG Ligong I-ORG University I-ORG SYLUTD202103 O The B-ORG Shenyang I-ORG Scientific I-ORG Plan I-ORG Project I-ORG 21-109-3-06 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O number O 31601459 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grant O number O BK20150149 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O number O 2016M590410 B-AWARD and O National O First-class O Discipline O Program O of O Light O Industry O Technology O and O Engineering O Grant O number O LITE2018-07 O The O APC O was O funded O by O National O First-class O Discipline O Program O of O Light O Industry O Technology O and O Engineering O Grant O number O LITE2018-07 O The O fabrication O of O the O substrates O and O laser O processing O technology O were O supported O by O RFBR B-ORG and I-ORG DFG O project O number O 21-53-12045 B-AWARD The O in O vivo O studies O and O all O Raman O investigations O were O supported O by O the B-ORG Russian I-ORG Science I-ORG Foundation O research O project O number O 19-75-10046 B-AWARD The O research O was O also O supported O by O the O Programme B-ORG of I-ORG Introducing I-ORG Talents I-ORG of I-ORG Discipline I-ORG to I-ORG Universities I-ORG D20018 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 31672529 B-AWARD and O 31402177 B-AWARD the O University B-ORG Nursing I-ORG Program I-ORG for I-ORG Young I-ORG Scholars I-ORG with I-ORG Creative I-ORG Talents I-ORG in I-ORG Heilongjiang I-ORG Province I-ORG Grant O No. O UNPYSCT-2017019 B-AWARD the O “Academic B-ORG Backbone” I-ORG Project I-ORG of I-ORG Northeast I-ORG Agricultural I-ORG University I-ORG Grant O No. O 17XG09 B-AWARD This O work O was O supported O by O Grants O from O the O Shanghai B-ORG health I-ORG and I-ORG family I-ORG planning I-ORG committee I-ORG funded O projects O of O China O No. O 201640046 B-AWARD Shanghai B-ORG Municipal I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 13ZR1405800 O and O Shanghai B-ORG Municipality I-ORG Health I-ORG Bureau I-ORG Youth I-ORG Project I-ORG 2013-121 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O BOX O study O was O funded O by O Diabetes B-ORG UK I-ORG 14/0004869 O The O SNAIL O study O was O funded O by O a O Strategic O Research O Agreement O from O the O JDRF B-ORG 17-2013-529 O AEL O was O funded O by O a O Diabetes O UK/JDRF O RD O Lawrence O Fellowship O 18/0005778 O and O 3-APF-2018-591-A-N B-AWARD DAP O was O funded O by O a O Wellcome B-ORG Trust I-ORG Senior O Investigator O Award O 100326/Z/12/Z O This O research O was O supported O by O grants O from O the B-ORG Talent I-ORG Programs I-ORG for I-ORG Fostering I-ORG Outstanding I-ORG Youth I-ORG of I-ORG Shanghai I-ORG grants O number O XYQ2013071 B-AWARD the B-ORG National I-ORG Science I-ORG Fund I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG grants O number O 81325017 B-AWARD Chang B-ORG Jiang I-ORG Scholars I-ORG Program I-ORG grants O number O T2014089 B-AWARD and O the B-ORG Key I-ORG Discipline I-ORG Construction I-ORG of I-ORG Public I-ORG Health I-ORG of I-ORG Shanghai I-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG grants O number O 12GWZX0101 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31672267 O and I-AWARD 31640074 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20160444 O the O Natural B-ORG Science I-ORG Research I-ORG General I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Provincial I-ORG Higher I-ORG Education I-ORG Institutions I-ORG 15KJB240002 O 12KJA180009 I-AWARD and I-AWARD 16KJA180008 O Jiangsu B-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Coastal I-ORG Wetland I-ORG Bioresources I-ORG and I-ORG Environmental I-ORG Protection I-ORG JLCBE14006 O the O Special B-ORG Guide I-ORG Fund I-ORG Project I-ORG of I-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG of I-ORG Yancheng I-ORG city I-ORG YKN2014022 O the O Jiangsu B-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG for I-ORG Bioresources I-ORG of I-ORG Saline I-ORG Soils I-ORG JKLBS2014013 O and I-AWARD JKLBS2015004 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O Instituto B-ORG Mexicano I-ORG del I-ORG Seguro I-ORG Social I-ORG FIS/IMSS/PROT/G16/1575 O to O JEMM O the O Secretaría B-ORG de I-ORG Educación I-ORG Pública I-ORG 103.5/16/10420 O to O MAGK O the O Consejo B-ORG Nacional I-ORG de I-ORG Ciencia I-ORG y I-ORG Tecnología I-ORG 264598 O to O MAGK O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O Scientific B-ORG Elitists I-ORG Project I-ORG of I-ORG Ordinary I-ORG Colleges I-ORG and I-ORG Universities I-ORG of I-ORG Guizhou I-ORG Province I-ORG QJH O KY I-AWARD 2019 I-AWARD 061 O Science B-ORG and I-ORG Technology I-ORG Platform I-ORG and I-ORG Talent I-ORG Team I-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Guizhou I-ORG Province I-ORG QKH O Platform O O Talent O 2017 B-AWARD 5721 O Project O on O the O Integration B-ORG of I-ORG Industry I-ORG Education I-ORG and I-ORG Research I-ORG of I-ORG Liupanshui I-ORG 52020-2018-04-12 O and O Applied B-ORG Basic I-ORG Research I-ORG Project I-ORG of O Yunnan O 2017FB150 O The O authors O are O grateful O for O the O support O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 11702053 O the B-ORG Major I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Henan I-ORG Province I-ORG 221100240400 O Shenzhen B-ORG undertakes I-ORG national I-ORG major I-ORG science I-ORG and I-ORG technology I-ORG projects I-ORG No. O CJGJZD20210408092602006 O This O work O was O supported O by O Program B-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 81570822 O Zhejiang B-ORG Key I-ORG Laboratory I-ORG Fund I-ORG of I-ORG China I-ORG No. O 2011E10006 O and O Zhejiang B-ORG Province I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2015C03042 O KY O is O the O recipient O This O work O was O also O supported O by O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG LQ15H120002 O and O Program B-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81500704 O YZ O is O the O recipient O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O following O fundings O The O General B-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Scientific I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 8187041227 B-AWARD The O General B-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Scientific I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2018A030313398 B-AWARD Medical B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG of I-ORG China I-ORG No. O B2018012 B-AWARD No.A2018117 O The O funding O body O played O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG project O no O 2017FYA0205300 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no O 81602184 B-AWARD Foundation B-ORG of I-ORG Tongren I-ORG Hospital I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG School I-ORG of I-ORG Medicine I-ORG no O TRYJ201515 B-AWARD and O Medical O engineering O cross O project O of O Shanghai O Jiao O Tong O University O no O YG2016ZD10 B-AWARD Contract O grant O sponsor O National B-ORG Natural I-ORG Science I-ORG Foundations I-ORG of I-ORG China O Contract O grant O number O 81670065 B-AWARD Jiangsu B-ORG Provincial I-ORG Medical I-ORG Youth I-ORG Talent O Contract O grant O number O QNRC2016317 B-AWARD Social B-ORG Development I-ORG Funds I-ORG of I-ORG Jiangsu I-ORG Province O Contract O grant O number O BE2017691 B-AWARD This O work O was O supported O by O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2014CB138703 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31770763 O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0500506 O The B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG lzujbky-2017-54 O The B-ORG Changjiang I-ORG Scholars I-ORG and I-ORG Innovative I-ORG Research I-ORG Team I-ORG in I-ORG University I-ORG IRT_17R50 O The B-ORG 111 I-ORG project I-ORG B12002 O These O funding O bodies O were O not O involved O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the O National O Institute O for O Health O Research O Public B-ORG Health I-ORG Research I-ORG Programme I-ORG project O number O 15/01/19 B-AWARD Intervention O costs O for O the O current O study O were O supported O by O Active O Norfolk O and O Suffolk O County O Council O Funding O was O also O received O from O the O Medical B-ORG Research I-ORG Council I-ORG project O number O MC_UU_12015/7 B-AWARD and O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG Biomedical I-ORG Research I-ORG Centre I-ORG Cambridge I-ORG Nutrition I-ORG Diet I-ORG and I-ORG Lifestyle I-ORG Research I-ORG Theme I-ORG Grant O IS-BRC-1215-20014 B-AWARD The O views O expressed O are O those O of O the O author(s O and O not O necessarily O those O of O the O National O Health O Service O the O National O Institute O for O Health O Research O or O the O Department O of O Health O and O Social O Care O This O work O was O supported O by O Beijing B-ORG Nova I-ORG Program I-ORG Z171100001117112 O Translational B-ORG Medicine I-ORG Program I-ORG of I-ORG Chinese I-ORG PLA I-ORG General I-ORG Hospital I-ORG 2017TM-022 O and O Youth B-ORG Talents I-ORG Promotion I-ORG Project I-ORG 17-JCJQ-QT-030 O The O funders O of O the O study O had O no O role O in O study O design O collection O analysis O or O interpretation O of O data O or O writing O of O the O report O We O greatly O appreciate O the O financial O support O from O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Xinjiang I-ORG Uygur I-ORG Autonomous I-ORG Region I-ORG Grant O No. I-AWARD 2020D01B61 O Agricultural O Science O and O Technology O Innovation O Program O of O the O Chinese O Academy O of O Agricultural O Sciences O CAAS O Cotton B-ORG Research I-ORG Institute I-ORG CRI I-ORG CAAS I-ORG Central I-ORG Level I-ORG Public I-ORG Welfare I-ORG Scientific I-ORG Institutes I-ORG Basic I-ORG Research I-ORG and I-ORG Business I-ORG Special I-ORG Funding I-ORG Project I-ORG Grant O No. I-AWARD 1610162021025 O and O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Cotton I-ORG Biology I-ORG ICR I-ORG CAAS I-ORG Grant O No. I-AWARD CB2021C10 O Project O funded O under O the O National B-ORG Recovery I-ORG and I-ORG Resilience I-ORG Plan I-ORG NRRP O Mission O 4. O Component O 2 O Investment O 1.4—Call O for O tender O No. O 3138 B-AWARD of O 16 O December O 2021 O rectified O by O Decree O n.3175 O of O 18 O December O 2021 O of O Italian B-ORG Ministry I-ORG of I-ORG University I-ORG and I-ORG Research I-ORG funded O by O the O European B-ORG Union—NextGenerationEU O Award O Number O Project O code O CN_00000033 B-AWARD Concession O Decree O No. O 1034 O of O 17 O June O 2022 O Adopted O by O the O Italian O Ministry O of O University O and O Research O CUP O H43C22000530001 B-AWARD Project O title O “National O Biodiversity O Future O Center—NBFC” O This O study O was O funded O by O the O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo I-ORG FAPESP O 2017/06630-7 B-AWARD and O 2020/01512-9 B-AWARD Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG Brasil I-ORG CAPES O Finance O Code O 001 B-AWARD Capes-print O 88881.311044/2018-00 O and O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq O 301721/2016-5 B-AWARD This O work O was O supported O by O Innovative B-ORG Research I-ORG Groups I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81721091 B-AWARD National B-ORG S&T I-ORG Major I-ORG Project I-ORG No. O 2017ZX10203205 B-AWARD National O Natural O Science O Foundation O of O China O NO. O 81874228 B-AWARD Science B-ORG Technology I-ORG Department I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. O 2015C03034 B-AWARD Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O LQ19H160035 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2019FZA7002 O This O work O was O supported O by O grants O from O Zhejiang B-ORG Provincial I-ORG Bureau I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG 2019ZB019 O 2019ZB020 O 2018ZB027 O the O Natural B-ORG Sciences I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG LY17H310009 O LQY18H160001 O LQY19H280002 O and O the B-ORG Sciences I-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2016F30009 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Award O number O 61674062 B-AWARD and O the O U.S B-ORG Department I-ORG of I-ORG Energy O Office O of O Basic O Energy O Sciences O Division O of O Materials O Sciences O and O Engineering O under O Contract O No. O DE-AC02-05CH11231 B-AWARD We O acknowledge O the O financial O support O from O the O National B-ORG Science I-ORG Foundation I-ORG NSF O under O Award O number O 0939514 B-AWARD This O study O was O partially O funded O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC81872475 O NSFC81372413 O Shandong B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG 2017CXGC1209 O 2017GSF18164 O the O Outstanding B-ORG Youth I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG JQ201423 O Jinan B-ORG Clinical I-ORG Medicine I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Plan I-ORG 201704095 O and O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0904700 O This O work O was O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG grant O no. O 0919929 B-AWARD to O OIL O National B-ORG Institutes I-ORG of I-ORG Health I-ORG grant O DA034748 B-AWARD to O JMS O and O Russian B-ORG Foundation I-ORG for I-ORG Basic I-ORG Research I-ORG grant O no. O 13-04-1704 B-AWARD to O OIL O Utrish O Dolphinarium-84 O Ltd O provided O support O in O the O form O of O salary O for O LMM O but O did O not O have O any O additional O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O specific O roles O of O these O authors O are O articulated O in O the O ‘author O contributions’ O section O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 61975174 B-AWARD and O 62105290 B-AWARD Science B-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Zhejiang I-ORG Province I-ORG grant O number O 2022C02034 B-AWARD and O Science B-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Shenzhen I-ORG grant O number O CJGJZD20210408092401004 B-AWARD This O project O has O been O funded O by O a O European O Association O of O Cardiovascular O Imaging O EACVI O part O of O the O ESC O Imaging B-AWARD Research I-AWARD Grant O a O UK O National O Institute O of O Health O Research O NIHR O Biomedical O Research O Center O BRC O Cardiometabolic O Research O Grant O at O University O College O London O UCL O BRC/199/JM/101320 B-AWARD and O a O Barts B-ORG Charity I-ORG Research O Grant O #1107/2356/MRC0140 B-AWARD G.C O is O supported O by O the O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG Rare B-AWARD Diseases I-AWARD Translational I-AWARD Research I-AWARD Collaboration I-AWARD NIHR O RD-TRC O and O by O the O NIHR O UCL O Hospitals O Biomedical O Research O Center O J.C.M O is O directly O and O indirectly O supported O by O the O UCL B-AWARD Hospitals I-AWARD NIHR I-AWARD BRC I-AWARD and I-AWARD Biomedical I-AWARD Research I-AWARD Unit I-AWARD at I-AWARD Barts I-AWARD Hospital I-AWARD respectively O This O work O was O in O part O supported O by O an O NIHR O BRC B-AWARD award I-AWARD to I-AWARD Cambridge I-AWARD University I-AWARD Hospitals I-AWARD NHS O Foundation O Trust O and O NIHR B-AWARD Cardiovascular I-AWARD Biomedical I-AWARD Research I-AWARD Unit I-AWARD support I-AWARD at I-AWARD Royal I-AWARD Brompton I-AWARD Hospital I-AWARD London I-AWARD UK. I-AWARD The O study O was O supported O by O Medical B-ORG I-ORG Health I-ORG Research I-ORG Key I-ORG Projects I-ORG of I-ORG Hainan I-ORG Province I-ORG China I-ORG No. O 2013Key-11 B-AWARD Science B-ORG I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG Sanya I-ORG City I-ORG No. O 2016YW12 B-AWARD and O Nursery B-ORG Foundation I-ORG of I-ORG Chinese I-ORG PLA I-ORG General I-ORG Hospital I-ORG No. O 14KMM34 B-AWARD All O funding O bodies O have O no O roles O in O study O design O data O collection O and O analysis O and O manuscript O preparation O This O project O was O supported O by O Research B-ORG Foundation I-ORG of I-ORG Hunan I-ORG Provincial I-ORG Education I-ORG Department I-ORG China I-ORG Grant O No. O 15A086 B-AWARD Hunan B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 2018JJ2177 B-AWARD Postgraduate B-ORG Research I-ORG and I-ORG Innovation I-ORG Project I-ORG of I-ORG Hunan I-ORG Province I-ORG Grants O No. O CX2016B285 B-AWARD and I-AWARD CX2016B314 O The O funders O had O no O role O in O the O design O of O the O study O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O or O in O the O decision O to O submit O the O article O for O publication O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81973424 O to O Z.X O the O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG CIFMS O 2016-I2M-3-016 O to O J.S O the O EU B-ORG grant I-ORG DISCO I-ORG grant O no. O 613513 B-AWARD and O Lazio O Region O project O ProBioZaff O 85-2017-15296 O to O G.G O and O the O US O National B-ORG Science I-ORG Foundation I-ORG 1442190 O to O V.A.A O The O support O for O Alain B-ORG Goriely I-ORG by I-ORG the I-ORG Engineering I-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG of I-ORG Great I-ORG Britain I-ORG under I-ORG research I-ORG grant O no. O EP/R020205/1 B-AWARD is O gratefully O acknowledged O The O research O of O Hamza O Alawiye O was O supported O by O UK B-ORG Engineering I-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG grant O no. O EP/L015811/1 B-AWARD This O work O was O supported O by O the O NSF B-ORG grant O no. O CMMI B-AWARD 1727268 I-AWARD to O E.K O This O study O has O been O supported O by O grants O awarded O by O the O European B-ORG Regional I-ORG Development I-ORG Fund I-ORG FEDER I-ORG Operational I-ORG Programme I-ORG Andalusia I-ORG 2014-2020 O Spanish O Research O Agency O SEJ-746-UGR20 B-AWARD “Effect O of O the O manipulation O of O contextual O variables O of O physical O exercise O on O mental O load O and O cognitive O emotional O and O athletic O performance” O and O Spanish B-ORG Ministry I-ORG of I-ORG Science I-ORG Innovation I-ORG and I-ORG Universities O Grant O FPU19/06224 B-AWARD and O Spanish B-ORG Ministry I-ORG of I-ORG Universities O Grant O FPU20/02022 B-AWARD This O work O is O supported O by O the O National B-ORG Postdoctoral I-ORG Program I-ORG for I-ORG Innovative I-ORG Talents I-ORG no. O BX201600140 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG no. O 2016M600484 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG WK2060190078 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 21701163 B-AWARD This O work O was O supported O by O Beijing B-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospital I-ORG Clinical I-ORG Medical I-ORG Development I-ORG of I-ORG Special I-ORG Funding I-ORG Support I-ORG XM201303 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81672770 O and O Beijing B-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG Z151100001615022 O to O DD. O The O funding O agencies O have O no O role O in O the O actual O experimental O design O patient O recruitment O data O collection O analysis O interpretation O or O writing O of O this O manuscript O This O work O was O supported O by O grants O from O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD1000700 O 2018YFD1000705 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31771854 O the O China B-ORG Scholarship I-ORG Council I-ORG 201804910055 O and O the O Key O Laboratory O of O Biology O and O Genetic O Improvement O of O Tuber O and O Root O Crop O Ministry O of O Agriculture O and O Rural O Affairs O P.R O China O No. O NYBSL201801 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81671924 O and O 81272105 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Key I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province O 2014B020212010 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG of I-ORG China I-ORG 2017YFC1103301 O and O Military B-ORG Medical I-ORG Innovation I-ORG Special I-ORG Projects I-ORG 18CXZ029 O This O work O was O supported O by O the B-ORG National I-ORG key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. I-AWARD 2018YFB1308000 O the O Special O Program O for O Science O and O Technology O of O National O Regional O Innovation O Center O of O Weihai O City O Grant O No. O 2017QYCX10 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. I-AWARD 51905119 O and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG Central I-ORG Universities I-ORG Grant O No. I-AWARD HIT.NSRIF.2020090 O This O work O was O supported O by O a O grant O from O the O “111 O Project” O from O the O Ministry O of O Education O of O China O and O the O State B-ORG Administration I-ORG of I-ORG Foreign I-ORG Expert I-ORG Affairs I-ORG of I-ORG China I-ORG No. O 111-2-07 B-AWARD and O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFA0902000 O and O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81700756 O This O work O was O supported O by O the O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG DTP O programme I-AWARD BB/J013854/1 O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG Imperial O Biomedical I-AWARD Research I-AWARD Centre O Natural B-ORG Environment I-ORG Research I-ORG Council I-ORG NE/LO11956/1 O Wellcome B-ORG Trust I-ORG 086418 O The O work O of O the O first O author O is O sponsored O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 52208398 B-AWARD and O Shanghai B-ORG Pujiang I-ORG Program I-ORG Grant O No. O 20PJ1406100 B-AWARD In O addition O financial O support O by O the O Sino-German B-ORG Center I-ORG for I-ORG Research I-ORG Promotion O provided O within O the O project O GZ B-AWARD 1574 O is O gratefully O acknowledged O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31902253 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20180921 O the O individual O technology O research O and O development O of O modern O agricultural O industry O of O Jiangsu O Province O CX(19)3024 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M632399 O the O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O and O the O earmarked O fund O for O Jiangsu O Agricultural O Industry O Technology O System O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61373108 B-AWARD the O Major B-ORG Projects I-ORG of I-ORG the I-ORG National I-ORG Social I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 11&ZD189 B-AWARD the O Science O and O Technology O Project O of O Guangzhou O No. O 201704030002 O and O Humanities B-ORG and I-ORG Social I-ORG Science I-ORG Foundation I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG 16YJCZH004 O The O funding O bodies O did O not O play O any O role O in O the O design O of O the O study O data O collection O and O analysis O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Social I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 20BJY143 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 72203093 O and O Scientific B-ORG research I-ORG startup I-ORG fund I-ORG of I-ORG Chuzhou I-ORG University I-ORG 2020qd21 O This O project O was O supported O by O Health B-ORG Commission I-ORG of I-ORG Sichuan I-ORG Province I-ORG 18PJ012 O 19ZD002 B-AWARD and O Science B-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2018JY0380 O Luzhou B-ORG government I-ORG and I-ORG Southwest I-ORG Medical I-ORG University I-ORG Cooperative I-ORG Project I-ORG No.2016lzxnyd-z01 O National O Nature O Science O Foundation O of O China O NO. O 81970026 O We O gratefully O acknowledge O the O financial O support O of O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 O Program O 2012CB114600 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31272500 O the O Specialized O Research O Fund O for O the O Doctoral B-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG 20113201130002 O and O a O project O funded O by O the O Priority O Academic O Program O of O Development O of O Jiangsu O Higher O Education O Institutions O This O work O was O supported O by O the O National B-ORG key I-ORG research I-ORG and I-ORG development I-ORG program I-ORG Grant O No. O 2018YFD0400403 B-AWARD and I-AWARD 2016YFD0400802 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O Grant O No. O 31701575 B-AWARD 31571801 O the O Support B-ORG Project I-ORG of I-ORG High-level I-ORG Teachers I-ORG in I-ORG Beijing I-ORG Municipal I-ORG Universities I-ORG in I-ORG the I-ORG Period I-ORG of I-ORG 13th I-ORG Five-year I-ORG Plan I-ORG Grant O No. O CIT&TCD201704042 B-AWARD BTBU O Basic O Scientific O Research O Operating O Fee O in O 2019 O PXM2019-014213-000007 O and O Talent O Training O Quality O Construction-First O Class O Professional O Construction O PXM2019-014213-000010 O This O research O was O funded O by O the O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG 2020A1515010432 O Project B-ORG of I-ORG Guangdong I-ORG Province I-ORG Key I-ORG Discipline I-ORG Scientific I-ORG Research I-ORG Level I-ORG Improvement I-ORG 2021ZDJS039 O 2022ZDJS067 B-AWARD Special B-ORG Innovation I-ORG Projects I-ORG of I-ORG Guangdong I-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG 2019KTSCX096 O 2020KTSCX076 B-AWARD Program B-ORG of I-ORG the I-ORG Hanshan I-ORG Normal I-ORG University I-ORG QN202020 O and O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Projects I-ORG of I-ORG Chaozhou I-ORG 2018GY18 O Financial O support O for O this O study O was O provided O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2016YFC1200601 O the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-23-D07 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31390421 O and O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O Number O 517000-X91502 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 32170063 B-AWARD Qingdao B-ORG National I-ORG Laboratory I-ORG for I-ORG Marine I-ORG Science I-ORG and I-ORG Technology I-ORG Marine I-ORG Biology I-ORG and I-ORG Biotechnology I-ORG Laboratory I-ORG 2018 I-ORG Open I-ORG Foundation I-ORG Program I-ORG grant O no. O OF2018NO04 B-AWARD and O Independent B-ORG Fund I-ORG Project I-ORG of I-ORG Tianjin I-ORG University I-ORG 2022XJS-0086 O The O study O was O funded O by O the O Medical B-ORG Research I-ORG Council I-ORG UK O Grant O No. O MR/N010469/1 B-AWARD TGC O is O funded O by O the O Medical O Research O Council O UK O Grant O no. O MR/K000551/1 B-AWARD and O MR/M01360X/1 B-AWARD MR/N010469/1 O MC_PC_15103 B-AWARD and O a O Newton O Institutional O Links O Grant O British O Council O 261868591 O The O MRC O eMedLab O computing O resource O was O used O for O bioinformatics O and O statistical O analysis O The O samples O from O Malawi O come O from O the O Wellcome B-ORG Trust I-ORG Funded O Malawi O Epidemiology O and O Intervention O Research O Unit O formerly O Karonga O Prevention O Study O and O were O sequenced O at O the O Wellcome O Trust O Sanger O Institute O Grant O No. O 098051 B-AWARD The O Portuguese O samples O were O collected O during O the O project O Task-Force O against O Tuberculosis O in O the O Greater O Lisbon O 2000–2012 O supported O by O Gulbenkian O Foundation O and O co-financed O by O Fundação B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG a I-ORG Tecnologia O Portugal O through O the O grants O UID/Multi/04413/2013 B-AWARD This O work O was O supported O by O the O Northwest O Native O American O Center O of O Excellence O NNACOE O and O the O Native O Hawaiian O Center O of O Excellence O NHCOE O which O are O funded O by O the O Health B-ORG Resources I-ORG and I-ORG Services I-ORG Administration O Bureau O of O Health O Workforce O under O grant O numbers O D34HP31026 B-AWARD for O NNACOE O and O D3HP16044 B-AWARD for O NHCOE O and O by O BUILD O EXITO O which O is O funded O by O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG under O grant O numbers O UL1GM118964 B-AWARD RL5GM118963 B-AWARD and B-AWARD TL4GM118965 O It O was O also O supported O by O National O Center O for O Advancing O Translational O Sciences O of O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG under O award O number O KL2TR002370 B-AWARD This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG SQ2021YFA1100604-02 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U21A20369 O and O the O Science B-ORG and I-ORG Technology I-ORG Programof I-ORG Sichuan I-ORG Province I-ORG Grant O No. O 2021YFS0191 B-AWARD None O of O the O funding O bodies O contributed O to O the O study O design O data O collection O analysis O interpretation O or O writing O of O the O manuscript O Funding O was O provided O by O American B-ORG Heart I-ORG Association I-ORG Grant O no. O 151708 B-AWARD National B-ORG Institutes I-ORG of I-ORG Health I-ORG Grant O no. O 1P01HL132825 B-AWARD and O European B-ORG Research I-ORG Council I-ORG 810115-DYNASET O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2016YFB1000400 O the B-ORG Harbin I-ORG Outstanding I-ORG Young I-ORG Talents I-ORG Fund I-ORG 2017RAYXJ016 O Nature B-ORG Scientific I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG F2018008 O This O work O was O supported O by O the O National B-ORG Agency I-ORG of I-ORG Research I-ORG and I-ORG Development I-ORG ANID-Chile O through O FONDECYT B-ORG Grants O N°120–0474 B-AWARD to O R.S-Z O Partial O support O was O received O from O DIUV-CI B-ORG Grant O N°01/2006 B-AWARD and O FONDECYT O Grants O N°120–1816 B-AWARD to O G.C O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 51205107 B-AWARD the O Top B-ORG Talents I-ORG Program I-ORG of I-ORG Hebei I-ORG Higher I-ORG Education I-ORG grant O no. O BJ2017011 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG province I-ORG grant O no. O E2019208306 B-AWARD and O the O Tribology B-ORG Science I-ORG Fund I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Tribology I-ORG grant O no. O SKLTKF16B01 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81860710 O and I-AWARD 81650030 O the O Guizhou B-ORG Provincial I-ORG Administration I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG QZYY-2016-018 O and I-AWARD QZYY-2018-098 O Funds O of O the O Guizhou B-ORG Provincial I-ORG Health I-ORG and I-ORG Health I-ORG Committee I-ORG gzwjkj2019-1-064 O the O Guizhou B-ORG Provincial I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2016-1165 O and I-AWARD 2017-5782 O the O Open O Funds O of O Key B-ORG Laboratory I-ORG of I-ORG Basic I-ORG Pharmacology I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG Zunyi I-ORG Medical I-ORG University I-ORG JCYL-K-012 O the O 15851 B-AWARD Talent B-ORG Elite I-ORG Project O the O Science B-ORG and I-ORG Technology I-ORG Joint I-ORG Funds I-ORG of I-ORG Zunyi I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG I-ORG the I-ORG First I-ORG People’s I-ORG Hospital I-ORG of I-ORG Zunyi I-ORG 2016-08 O 2017-29 I-AWARD 2018-160 I-AWARD 2018-167 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O We O gratefully O acknowledge O the O following O funding O Office O of O Research O Development O Phramongkutklao O College O of O Medicine O O Phramongkutklao O Hospital O ORD O PCM O O PMK O Bangkok O Thailand O Thailand B-ORG Research I-ORG Fund I-ORG TRG6080009 O British O Council O and O Newton B-ORG Fund I-ORG for O Thailand-UK O researcher O Link O award O 2017-18 O PDG61W0015 O Research O Incentive O Grant O Scheme O of O International B-ORG Islamic I-ORG University I-ORG Malaysia I-ORG Grant O no O RIGS B-AWARD 17-007-0582 O Australian O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG NHMRC O Centres O for O Research O Excellence O Grant O ID: O 1110343 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81372907 O 81301757 O 81472531 B-AWARD 81402009 O 81572787 O and O 81672683 O the O Natural O Science O Foundation O of O Hunan O Province O 14JJ1010 O and O 2015JJ1022 O the B-ORG Mittal I-ORG Innovation I-ORG Foundation I-ORG of I-ORG Central I-ORG South I-ORG University I-ORG MX2016442 O and O 15MX46 B-AWARD and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG Central I-ORG Universities I-ORG of I-ORG Central I-ORG South I-ORG University I-ORG 2016zzts478 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31820103010 B-AWARD 31771953 I-AWARD 31871774 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG JUSRP51903B O the O National B-ORG first I-ORG class I-ORG discipline I-ORG program I-ORG of I-ORG Food I-ORG Science I-ORG and I-ORG Technology I-ORG JUFSTR20180102 O This O work O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG 2018J01701 O the O Earmarked B-ORG Fund I-ORG for I-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-19 O the O Special B-ORG Fund I-ORG Project I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG of I-ORG Fujian I-ORG Agriculture I-ORG and I-ORG Forestry I-ORG University I-ORG CXZX2017164 O CXZX2018069 O the O Rural B-ORG Revitalization I-ORG Tea I-ORG Industry I-ORG Technical I-ORG Service I-ORG Project I-ORG of I-ORG Fujian I-ORG Agriculture I-ORG and I-ORG Forestry I-ORG University I-ORG 11899170102 O and O the O Construction B-ORG of I-ORG Plateau I-ORG Discipline I-ORG of I-ORG Fujian I-ORG Province I-ORG 102/71201801101 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O grants O from O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG MOST O 110-2314-B-016-020-MY3 O MOST B-AWARD 110-2314-B-016-019-MY2 O MOST B-AWARD 111-2314-B-016-036 O grants O from O the O Tri-Service B-ORG General I-ORG Hospital I-ORG Research I-ORG Foundation I-ORG TSGH-C01-112026 O TSGH-C03-111031 B-AWARD TSGH-C04-110026 B-AWARD and O grants O from O the O Ministry B-ORG of I-ORG National I-ORG Defense–Medical I-ORG Affairs I-ORG Bureau I-ORG MND-MAB-110-91 O MND-MAB-D-111112 B-AWARD MND-MAB-C10-112041 B-AWARD Taipei O Taiwan O This O work O was O supported O by O the O National B-ORG Key I-ORG Technology I-ORG R&D I-ORG Program I-ORG in I-ORG the I-ORG 12th I-ORG Five-Year I-ORG Plan I-ORG of I-ORG China I-ORG No. O 2011BAI11B06 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81872692 B-AWARD and O the O Beijing B-ORG Municipal I-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 7182085 B-AWARD This O work O was O supported O as O part O of O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shaanxi I-ORG No. O 2020SF-176 B-AWARD with O the O funder O Miaojing O Li, O and O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG under O grant O No. O 2021PT-039 B-AWARD with O the O funder O Pengxiang O Qu, O and O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O grant O No. O 32100649 B-AWARD with O the O funder O Pengxiang O Qu. O This O study O was O supported O by O the B-ORG Science I-ORG and I-ORG Technology I-ORG Colleges I-ORG Innovation I-ORG Team I-ORG Support I-ORG Program I-ORG of I-ORG Henan I-ORG Province I-ORG No. O 18IRTSTHN024 B-AWARD the B-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Henan I-ORG Province I-ORG co-established I-ORG by I-ORG the I-ORG province I-ORG and I-ORG the I-ORG ministry I-ORG No. O 201701002 B-AWARD and O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O U1604172 B-AWARD This O research O was O funded O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2018YFA0209000 B-AWARD the O Beijing B-ORG Municipal I-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 4222060 B-AWARD and O the O National B-ORG Science I-ORG Fund I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG No. O 52202159 B-AWARD This O research O was O funded O by O the O Inner B-ORG Mongolia I-ORG Autonomous I-ORG Region I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Foundation I-ORG grant O numbers O 2020GG0287 B-AWARD 2020GG0257 B-AWARD and O 2022YFHH0050 B-AWARD Inner B-ORG Mongolia I-ORG University I-ORG of I-ORG Technology I-ORG Foundation I-ORG grant O number O ZZ201911 B-AWARD Inner B-ORG Mongolia I-ORG University I-ORG of I-ORG Technology I-ORG Educational I-ORG Reform I-ORG Foundation I-ORG grant O number O 2022109 B-AWARD Inner B-ORG Mongolia I-ORG Autonomous I-ORG Region I-ORG Higher I-ORG Education I-ORG Basial I-ORG Research I-ORG Foundation I-ORG grant O number O JY20220380 B-AWARD and O the O Inner B-ORG Mongolia I-ORG Autonomous I-ORG Region I-ORG Graduate I-ORG Student I-ORG Innovation I-ORG Research I-ORG Foundation I-ORG grant O number O S20210189Z B-AWARD This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG #81771589 O the B-ORG Program I-ORG of I-ORG Tianjin I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG # O 18ZXDBSY00170 B-AWARD and O the B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Tianjin I-ORG #14RCGFSY00150 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O 81570703 B-AWARD the B-ORG National B-ORG Science I-ORG Foundation I-ORG for I-ORG Young I-ORG Scholars I-ORG 81704090 O 81503588),and B-AWARD the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Chongqing I-ORG cstc2015jcyjA10113 O cstc2017jcyjbx0044 B-AWARD Both O projects O are O not O in O a O financial O or O personal O relationship O to O this O study O This O research O is O supported O by O the O following O projects O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O U1204524 B-AWARD the O Henan B-ORG province I-ORG science I-ORG and I-ORG technology I-ORG key I-ORG project I-ORG Grant O 172102210302 B-AWARD the O Henan B-ORG college I-ORG key I-ORG scientific I-ORG research I-ORG project I-ORG Grant O 18A416002 B-AWARD and O the O Development O of I-ORG key I-ORG technologies I-ORG for I-ORG electrically I-ORG driven I-ORG inter I-ORG robot I-ORG weeding I-ORG robot I-ORG based I-ORG on I-ORG machine I-ORG vision I-ORG technology I-ORG KF1607 O This O work O was O supported O by O the O Korea B-ORG Institute I-ORG of I-ORG Industrial I-ORG Technology I-ORG as O Research O Source O Technique O Project O KITECH O EO180026 O Basic O Science O Research O Program O through O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O funded O by O the O Ministry O of O Science O and O ICT O 2018R1A2B6008815 O Korea B-ORG Electric I-ORG Power I-ORG Corporation I-ORG R19XO01-05 O and O the O BK21 O Plus O project O funded O by O the O Ministry O of O Education O Korea O 21A20131600011 O This O study O was O supported O by O Grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81460362 B-AWARD 81773116 B-AWARD 81760436 B-AWARD 81560399 B-AWARD 81860518 O and O 81360358 B-AWARD the B-ORG medical I-ORG and I-ORG health I-ORG science I-ORG and I-ORG technology I-ORG project I-ORG of I-ORG Suzhou I-ORG high I-ORG tech I-ORG Zone I-ORG No. O 2017Z006 B-AWARD the O international O science O and O technology O cooperation O project O of O Shihezi O University O No. O GJHZ201702 O the B-ORG Applied I-ORG Basic I-ORG Research I-ORG Projects I-ORG of I-ORG Xinjiang I-ORG Production I-ORG and I-ORG Construction I-ORG Corps I-ORG No. O 2016AG020 B-AWARD the O Youth O Science O and O Technology O Innovation O Leading O Talents O Project O of O Corps O 2017CB004 O the B-ORG Major I-ORG science I-ORG and I-ORG technology I-ORG projects I-ORG of I-ORG Shihezi I-ORG University I-ORG No. O gxjs2014-zdgg06 B-AWARD the B-ORG high-level I-ORG talent I-ORG project I-ORG of I-ORG Shihezi I-ORG University I-ORG No. O RCZX201533 B-AWARD and O the B-ORG Foundation I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG of I-ORG Shihezi I-ORG University I-ORG No. O 2015ZRKXJQ02 B-AWARD The O funders O were O not O involved O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Erasmus B-ORG Medical I-ORG Centre I-ORG Health I-ORG Care I-ORG Efficiency I-ORG grant O 2010-10112 B-AWARD Erasmus B-ORG MC I-ORG Vriendenfonds I-ORG grant O 104117 B-AWARD and O Stichting B-ORG Coolsingel I-ORG grant O 255 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O number O 31500251 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG Grant O number O LQ13C060003 B-AWARD and O the O China B-ORG Scholarship I-ORG Council I-ORG Grant O number O 201508330107 B-AWARD This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U1762218 O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Polymer I-ORG Materials I-ORG Engineering I-ORG sklpme2018–3–07 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG YJ201831 O This O work O was O supported O by O the O grant O from O the O Science B-ORG and I-ORG Technology I-ORG Projects I-ORG of I-ORG Chongqing I-ORG Municipal I-ORG Education I-ORG Commission I-ORG China I-ORG No. O KJQN201801225 B-AWARD the O Chongqing B-ORG Technological I-ORG Innovation I-ORG and I-ORG Application I-ORG Development I-ORG Project I-ORG cstc2019jscx-lyjsAX0005 O and O the O Chongqing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Project I-ORG cstc2020jcyj-msxmX0317 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Weiling O ZHU O thanks O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 12074441 B-AWARD Sumei O HU O thanks O the O Guangdong B-ORG Province I-ORG Special I-ORG Foundation I-ORG of I-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG Grant O No. O 2021S055 B-AWARD and O Di O GU O thanks O the O Projects B-ORG of I-ORG PhDs’ I-ORG Start-up I-ORG Research I-ORG of I-ORG GDUPT I-ORG Grant O No. O 2020bs008 B-AWARD for O their O financial O assistance O This O work O has O been O supported O by O the O financial O support O of O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61771165 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Funded I-ORG Project I-ORG No. O 2014M551246 B-AWARD 2018T110302 O Innovation B-ORG Project I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Tree I-ORG Genetics I-ORG and I-ORG Breeding I-ORG Northeast O Forestry O University O No.2019A04 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 2572018BH01 B-AWARD National B-ORG Undergraduate I-ORG Innovation I-ORG Project I-ORG No. O 201910225184 B-AWARD and O Specialized B-ORG Personnel I-ORG Start-up I-ORG Grant I-ORG Also O National O Construction O Plan O of O World-class O Universities O and O First-class O Disciplines O No. O 41113237 B-AWARD The O funding O body O of O Natural O Science O Foundation O of O China O played O an O important O role O in O the O design O of O the O study O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O financially O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81801582 O Guangzhou B-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG Project I-ORG 20182A011021 O Guangdong B-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG 80022017ZC0251 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2016A030310277 O This O study O was O supported O by O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Projects I-ORG for I-ORG “Major I-ORG New I-ORG Drugs I-ORG Innovation I-ORG and I-ORG Development” I-ORG of I-ORG China I-ORG grant O number O 2012ZX09506001-001 B-AWARD the B-ORG National I-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 31200749 B-AWARD and O Northwest B-ORG University I-ORG Graduate I-ORG Innovation I-ORG and I-ORG Creativity I-ORG Funds I-ORG grant O number O YZZ15008 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 32272942 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Chongqing I-ORG China I-ORG cstc2021jcyj-cxttX0005 O cstc2021jcyj-msxmX1003 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG SWU-KT22033 O This O study O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG No. O 22ZR1411900 B-AWARD the O Biomedical B-ORG Technology I-ORG Supporting I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG No. O 22S11900300 B-AWARD and O the O Shanghai B-ORG Sailing I-ORG Program I-ORG No. O 22YF1407300 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O research O of O XS O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61503419 B-AWARD the O Guangdong B-ORG Nature I-ORG Science I-ORG Foundation I-ORG No. O 2014A030310355 B-AWARD 2016A030313234 B-AWARD and O the O “985 O project” O of O Sun O Yat-sen O University O No. O 50000-31101302 O The O research O of O JZ O was O supported O by O grants O from O the O National O Natural O Science O Foundation O of O China O No. O 11475273 O The O research O of O QZ O was O supported O by O the O Innovation O Team O Project O No: O LT2015011 B-AWARD from O the O Education B-ORG Department I-ORG of I-ORG Liaoning I-ORG Province O The O research O of O XC O was O supported O by O a O grant O from O the O National O Natural O Science O Foundation O of O China O No. O 11301517 B-AWARD The O research O of O WZ O was O supported O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 13ykpy07 O The O research O of O GY O was O supported O by O a O grant O from O the O National O Natural O Science O Foundation O of O China O No. O 81373428 B-AWARD The O research O of O TS O was O supported O by O a O grant O from O the O National O Natural O Science O Foundation O of O China O No. O 91230204 B-AWARD The O funders O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O of O the O manuscript O Support O was O provided O by: O the O Department B-ORG of I-ORG Biotechnology I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Award O Number O BT/Bio-CARe/02/604/2011-12 B-AWARD Recipient O P. O Sharmila O University B-ORG of I-ORG Delhi I-ORG IN) I-ORG Award O Number O RC/2015/9677 B-AWARD Recipient O P. O Pardha-Saradhi O Ph.D O Korea B-ORG Environmental I-ORG Industry I-ORG and I-ORG Technology I-ORG Institute I-ORG Award O Number O 2015001790002 B-AWARD Recipient O Hyunook O Kim O and O University B-ORG Grants I-ORG Commission I-ORG Award O Number O 3625(NET-DEC.2012 B-AWARD Recipient O Nisha O Shabnam O The O funding O received O during O this O specific O study O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O this O manuscript O This O research O was O supported O by O grants O from O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea O funded O by O the O Korean O government O 2017R1A2B4009963 O and O the O Korea B-ORG Institute I-ORG of I-ORG Oriental I-ORG Medicine I-ORG grant O K18182 B-AWARD given O to O H.J.P O and O by O grants O of O the O Korea O Health O Technology O R&D O Project O through O the O Korea B-ORG Health I-ORG Industry I-ORG Development I-ORG Institute I-ORG KHIDI O funded O by O the O Ministry O of O Health O O Welfare O HI17C1357 O given O to O S.I.I O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81301930 B-AWARD and O General B-ORG project I-ORG of I-ORG Education I-ORG Department I-ORG of I-ORG Liaoning I-ORG Province I-ORG Grant O No. O L2015595 B-AWARD College B-ORG Students I-ORG Innovation I-ORG Project I-ORG No. O 201610159000036 B-AWARD Liaoning B-ORG Province I-ORG key I-ORG Research I-ORG I-ORG Directing I-ORG Project I-ORG Grant O No.2018225085 O We O are O grateful O for O the O research O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51509130 O 41475107 I-AWARD 51779161 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20150908 O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG during I-ORG the I-ORG Twelfth I-ORG Five–Year I-ORG Plan I-ORG 2014BAD10B07 O and O the O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O The O funding O bodies O were O not O involved O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2018YFD1000100 O the B-ORG earmarked I-ORG fund I-ORG for I-ORG the I-ORG China I-ORG Agricultural I-ORG Research I-ORG System I-ORG CARS-27 O the O Construction O of O Beijing O Science O and O Technology O Innovation O and O Service O Capacity O in O Top O Subjects O CEFF-PXM2019_014207_000032 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21028370 O faculty O start-up O funds O provided O by O China B-ORG Agricultural I-ORG University I-ORG 31051018 O 111 B-ORG Project I-ORG no. O B17043 O and O the O Key O Laboratory O of O Biology O and O Genetic O Improvement O of O Horticultural O Crops O Nutrition O and O Physiology O Ministry O of O Agriculture O This O study O was O supported O by O contract O grant O sponsors O and O numbers O Jiangsu B-ORG Provincial I-ORG Women I-ORG and I-ORG Children I-ORG Health I-ORG Research I-ORG Project I-ORG grant O no. O F201816 B-AWARD and O F201744 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 81600687 B-AWARD and O 81701491 B-AWARD Nanjing B-ORG Medical I-ORG Science I-ORG and I-ORG Technique I-ORG Development I-ORG Foundation I-ORG grant O no. O YKK18155 B-AWARD Jiangsu B-ORG Provincial I-ORG Medical I-ORG Youth I-ORG Talent I-ORG grant O no. O QNRC2016111 B-AWARD and O Six B-ORG Talent I-ORG Peaks I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG grant O no. O YY-112 B-AWARD This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO. O 51808069 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG NO. O 2019M653339 B-AWARD 111 O Project O NO. O B18062 O and O Chongqing B-ORG Postdoctoral I-ORG Science I-ORG Special I-ORG Foundation I-ORG NO. O XmT2018035 B-AWARD This O work O is O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61475134 O 61775032 I-AWARD and I-AWARD 11604042 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG N170405007 O N180406002 I-AWARD N180408018 I-AWARD and I-AWARD N160404009 O and O 111 B-ORG Project I-ORG B16009 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31671544 O Hunan B-ORG Provincial I-ORG Innovation I-ORG Foundation I-ORG of I-ORG Postgraduate I-ORG CX2014B228 O and O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2016YFC1000606 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 51775428 B-AWARD Open B-ORG Project I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Digital I-ORG Manufacturing I-ORG Equipment I-ORG and I-ORG Technology I-ORG Grant O No. O DMETKF2017014 B-AWARD Project B-ORG of I-ORG Key I-ORG Laboratory I-ORG of I-ORG Shaanxi I-ORG Provincial I-ORG Education I-ORG Department I-ORG of I-ORG China I-ORG Grant O No. O 15JS068 B-AWARD and O Project B-ORG of I-ORG PhD I-ORG Innovation I-ORG Foundation I-ORG of I-ORG Xi’an I-ORG University I-ORG of I-ORG Technology I-ORG Grant O No. O 310-252071701 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O is O supported O by O grants O from O the O Project B-ORG for I-ORG Developing I-ORG Top I-ORG Western I-ORG Disciplines I-ORG in I-ORG University I-ORG Public O Health O and O Preventive O Medicine O No. O NXYLXK2017B08 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81460490 B-AWARD and O the B-ORG Important I-ORG Research I-ORG Topic I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG Ningxia I-ORG No. O 2017-NW-018 B-AWARD The O funders O had O no O role O in O the O design O of O the O study O in O the O collection O analysis O and O interpretation O of O data O or O in O the O writing O of O the O manuscript O and O the O decision O to O publish O The O uthors O are O grateful O to O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 51875320 B-AWARD the O Major O projects O of O National B-ORG Science I-ORG and I-ORG Technology I-ORG Grant O No. O 2019ZX04001031 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG Grant O No. O 2018YFB2002201 B-AWARD the O Natural O Science O Outstanding O Youth O Fund O of O Shandong O Province O Grant O No. O ZR2019JQ19 O and O the O Key O Laboratory O of O High-Efficiency O and O Clean O Mechanical O Manufacture O at O Shandong O University O Ministry O of O Education O This O research O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangxi I-ORG Province I-ORG Grant O No. O 2022GXNSFBA035536 B-AWARD and O awarded O to O L.Y O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31960203 B-AWARD and O 31860245 B-AWARD and O awarded O to O D.Y O and O L.P O and O the O Basic B-ORG Research I-ORG Fund I-ORG of I-ORG Guangxi I-ORG Academy I-ORG of I-ORG Sciences I-ORG Grant O No. O 2020YBJ701 B-AWARD and O awarded O to O L.Y O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O No. O 81800999 B-AWARD for O the O design O of O the O study O the B-ORG Scientific I-ORG and I-ORG Technological I-ORG Research I-ORG Program I-ORG of I-ORG Chongqing I-ORG Municipal I-ORG Education I-ORG Commission I-ORG grant O No. O KJQN201800414 B-AWARD for O collection O analysis O and O interpretation O of O data O and O the B-ORG Program I-ORG for I-ORG Innovation I-ORG Team I-ORG Building I-ORG at I-ORG Institutions I-ORG of I-ORG Higher I-ORG Education I-ORG in I-ORG Chongqing I-ORG in I-ORG 2016 I-ORG grant O No. O CXTDG201602006 B-AWARD for O writing O the O manuscript O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC1700200 O 2017YFC0908405 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 1350219165 O Shanghai B-ORG Sailing I-ORG Program I-ORG 19YF1441100 O Funding O for O open O access O charge O National O Key O R&D O Program O of O China O 2017YFC1700200 O 2017YFC0908405 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O grants O 61903073 O and O 6193300 O and O part O by O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Synthetical I-ORG Automation I-ORG for I-ORG Process I-ORG Industries I-ORG under O Grant O 2013ZCX09 B-AWARD Hebei B-ORG Natural I-ORG Science I-ORG Foundation I-ORG under O Grant O No. O F2020501040 B-AWARD This O research O is O supported O by O the B-ORG Youth I-ORG Project I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 11504077 O the O National O Natural O Science O Foundation O of O China O 61774053 O the B-ORG Youth I-ORG Project I-ORG of I-ORG Hebei I-ORG Province I-ORG Natural I-ORG Science I-ORG Foundation I-ORG A2017201012 O and O the B-ORG Key I-ORG Project I-ORG of I-ORG Hebei I-ORG Province I-ORG Department I-ORG of I-ORG Education I-ORG Fund I-ORG ZD2017007 O The O research O leading O to O these O results O has O received O funding O from O Associazione B-ORG Italiana I-ORG per I-ORG la I-ORG Ricerca I-ORG sul I-ORG Cancro I-ORG AIRC O under O the O grant O number O 21846 B-AWARD grant O recipient O MC O Ministero B-ORG dell’Istruzione I-ORG dell’Università I-ORG e I-ORG della I-ORG Ricerca I-ORG PRIN O under O the O grant O number O 2017XJ38A4-004 B-AWARD grant O recipient O MC O and O Regione B-ORG Campania I-ORG Progetto O GENOMAeSALUTE B-AWARD grant O recipient O MC O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O grants O from O the O China’s B-ORG 13th I-ORG Five I-ORG Year I-ORG Programs I-ORG for I-ORG the I-ORG prevention I-ORG and I-ORG cure I-ORG of I-ORG great I-ORG infectious I-ORG diseases I-ORG No. O 2017ZX10201301-005 B-AWARD 2018ZX10731301-001-005];National O Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No.2018YFD0500900];International O cooperation O and O exchange O program O of O Shanghai O Municipal O No. O 16430724000 O and O grants O from O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG MOP-106559 O PJT156261 O The O authors O gratelfully O acknowledge O financial O support O from O China O Scholarship O Council O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31672512 O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG KYZ201212 O the B-ORG Priority I-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O and O Jiangsu O Collaborative O Innovation O Centre O of O Meat O Production O and O Processing O Quality O and O Safety O Control O This O work O was O supported O by O the O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG grant O no. O JX10231801 B-AWARD the B-ORG Provincial I-ORG Initiative I-ORG Program I-ORG for I-ORG Excellency I-ORG Disciplines I-ORG of I-ORG Jiangsu I-ORG Province I-ORG grant O no. O BE2016791 B-AWARD and O six B-ORG talent I-ORG peak I-ORG project I-ORG in I-ORG Jiangsu I-ORG province I-ORG grant O no. O WSW-025 B-AWARD This O work O is O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61704011 O 61574022 I-AWARD 61504012 I-AWARD 61674021 I-AWARD 11404219 I-AWARD 11404161 I-AWARD 11574130 I-AWARD 11674038 O the B-ORG Foundation I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG High I-ORG Power I-ORG Semiconductor I-ORG Lasers I-ORG the I-ORG Developing I-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Jilin I-ORG Province I-ORG 20160519007JH O 20160520117JH I-AWARD 20160101255JC I-AWARD 20160204074GX I-AWARD 20170520117JH O and O the B-ORG Foundation I-ORG of I-ORG NANO I-ORG X(18JG01 O RC O acknowledges O the B-ORG national I-ORG 1000 I-ORG plan I-ORG for I-ORG young I-ORG talents I-ORG and I-ORG Shenzhen I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Committee I-ORG Projects O Nos O JCYJ20150630162649956 B-AWARD JCYJ20150930160634263 I-AWARD and I-AWARD KQTD2015071710313656 O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 51875170 B-AWARD and O 51505127 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province O grant O number O BK20161197 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of O China O grant O number O 2018B22414 B-AWARD Changzhou O Sci&Tech O Program O grant O number O CE20195037 O Open O Fund O of O Jiangsu O Key O Laboratory O of O Special O Robot O Technology O grant O number O 2017JSJQR04 O This O work O was O supported O by O the O following O funding O sources O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III O grant O numbers O PI21/01596 B-AWARD the O Government O of O the O Principado O de O Asturias O through O the B-ORG Fundación I-ORG para I-ORG el I-ORG Fomento I-ORG en I-ORG Asturias I-ORG de I-ORG la I-ORG Investigación I-ORG Científica I-ORG Aplicada I-ORG y I-ORG la I-ORG Tecnología I-ORG FICYT O and O the O European O Union O GRUPIN O grant O number O IDI/2021/000033 B-AWARD the O Instituto B-ORG de I-ORG Investigación I-ORG Sanitaria I-ORG del I-ORG Principado I-ORG de I-ORG Asturias I-ORG ISPA O grant O number O 2021-030-INTRAMURALES-POOCY B-AWARD E.A O thanks O his O pre-doctoral O fellowship O to O Instituto O de O Salud O Carlos O III O grant O number O FI22/00286 O and O C.G.-G O thanks O her O postdoctoral O fellowship O to O FICYT-Ayudas O Margarita O Salas O Joven O grant O number O AYUD/2021/58477 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31672529 B-AWARD and O No. O 31402177 O the O University B-ORG Nursing I-ORG Program I-ORG for I-ORG Young I-ORG Scholars I-ORG with I-ORG Creative I-ORG Talents I-ORG in I-ORG Heilongjiang I-ORG Province I-ORG Grant O No. O UNPYSCT-2017019 B-AWARD the O “Academic B-ORG Backbone” I-ORG Project I-ORG of I-ORG Northeast I-ORG Agricultural I-ORG University I-ORG Grant O No. O 17XG09 B-AWARD and O the O “Young B-ORG Talents” I-ORG Project I-ORG of I-ORG Northeast I-ORG Agricultural I-ORG University I-ORG Grant O No. O 16QC25 B-AWARD This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81571587 O 81771757 B-AWARD CAMS B-ORG Initiative I-ORG for I-ORG Innovative I-ORG Medicine I-ORG 2017-12M-3-001 O and O The B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0901500 O This O work O was O supported O by O the B-ORG Florida I-ORG Citrus I-ORG Research I-ORG and I-ORG Development I-ORG Foundation I-ORG CRDF O Grant O No. O 15-010 B-AWARD Frederick O G. O Gmitter O Jr O United B-ORG States I-ORG Department I-ORG of I-ORG Agriculture-National I-ORG Institute I-ORG of I-ORG Food I-ORG and I-ORG Agriculture-Specialty I-ORG Crop I-ORG Research I-ORG Initiative I-ORG USDA-NIFA O SCRI O Grant O No. O 2017-70016-26328 B-AWARD Frederick O G. O Gmitter O Jr O the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2018YFD0201500 B-AWARD Zhen O Song O the B-ORG Earmarked I-ORG Fund I-ORG for I-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-27 O Shanchun O Chen O and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG XDJK2019B018 O Lixiao O Yao O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Modern B-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG system I-ORG CARS-44-B-1 O Funds B-ORG of I-ORG Shandong I-ORG “Double I-ORG Tops” I-ORG Program I-ORG 2017 O and O Project B-ORG Funded I-ORG by I-ORG China I-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2015M580601 O This O work O was O supported O by O the O National O Institutes O of O Health O National B-ORG Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases O grant O number O AI097493 B-AWARD awarded O to O SO O https://www.niaid.nih.gov O the O Bill B-ORG and I-ORG Melinda I-ORG Gates I-ORG Foundation O grant O number O OPP1034619 B-AWARD awarded O to O SO O http://www.gatesfoundation.org O National O Institutes O of O Health O National O Institute O of O Allergy O and O Infectious O Diseases O grant O number O U01AI075420 O awarded O to O JMV O Fogarty O International O grant O D43TW007120 O awarded O to O JMV O https://www.fic.nih.gov/Pages/Default.aspx O and O the O UK O Medical B-ORG Research I-ORG Council O Grant O ref O MR/K000551/1 B-AWARD awarded O to O FM O and O MP O http://www.mrc.ac.uk O The O funders O had O no O role O in O study O design O data O collection O data O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O The B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0903900 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81771766 O 81771765 I-AWARD 81373206 I-AWARD 81401357 I-AWARD 81671622 I-AWARD 81701621 I-AWARD 81671621 O and O the O Independent B-ORG Innovation I-ORG Projects I-ORG of I-ORG Central I-ORG South I-ORG University I-ORG 2016zzts131 O This O study O was O supported O in O part O by O the O grants O from O National B-ORG Science I-ORG Council O Taiwan O NSC O 105-2320-B-182A-010 O NSC O 104-2320-B-182A-004 B-AWARD Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology O Taiwan O MOST O 104-2320-B-182A-010 O MOST B-AWARD 105-2320-B-182A-016 O Chang B-ORG Gung I-ORG Memorial I-ORG Hospital I-ORG CMRPG8B1251-3 O CMRPG8C0591-2 B-AWARD CMRPG8E1471 B-AWARD and O Kaohsiung B-ORG Medical I-ORG University I-ORG Aim O for O the O Top O Universities O Grant O grant O No. O KMU-TP104E27 B-AWARD KMU-TP105E23 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O is O financially O sponsored O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 21536004 B-AWARD Shanghai B-ORG Commission I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG No. O 15JC1400403 B-AWARD and O Shanghai B-ORG Pujiang I-ORG Program I-ORG No. O 15PJ1401200 B-AWARD This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O China O Grant O No: O 51805099 B-AWARD 51605103 O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province O China O 2017B090914005 O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou O China O 201805010001 O Project O of O Department O of O Education O Guangdong O Province O No:2017GCZX003 O and O Beijing O Institute O of O Technology O Research O Fund O Program O for O Young O Scholars O China O This O work O has O been O partially O funded O by O College B-ORG of I-ORG Nurses I-ORG of I-ORG Lleida I-ORG and I-ORG Department I-ORG of I-ORG Health I-ORG of I-ORG Generalitat I-ORG de I-ORG Catalunya I-ORG grant O number O SLT002/16/00384 B-AWARD and O also O was O supported O by O “Fundació O La I-ORG Marató I-ORG TV3” O 464/C/2014 O and O by O IRBLleida B-ORG Biobank I-ORG B.0000682 O There O was O no O additional O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 82270549 B-AWARD 82000481 B-AWARD and O 82073056 B-AWARD the O Shanghai B-ORG Sailing I-ORG Program I-ORG No. O 20YF1429400 B-AWARD the O Qingfeng B-ORG Scientific I-ORG Research I-ORG Fund I-ORG of I-ORG the I-ORG China I-ORG Crohn’s I-ORG I-ORG Colitis I-ORG Foundation I-ORG CCCF O No. O CCCF-QF-2022C14-21 B-AWARD and O Shanghai B-ORG Pujiang I-ORG Talent I-ORG Program I-ORG 19PJ1407600 O This O research O was O funded O by O “National O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 32171800” B-AWARD “Natural O Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG of I-ORG China O grant O number O C2019204276” B-AWARD and O “Basic O Scientific I-ORG Research I-ORG of I-ORG Universities I-ORG in I-ORG Hebei I-ORG Province I-ORG of I-ORG China O grant O number O KY202008” B-AWARD This O study O was O supported O by O Instituto B-ORG Nacional I-ORG de I-ORG Tecnología I-ORG Agropecuaria I-ORG INTA O grants O PNBIO1131033 B-AWARD and O PNBIO1131043 B-AWARD Agencia B-ORG Nacional I-ORG de I-ORG Promoción I-ORG Científica I-ORG y I-ORG Tecnológica I-ORG ANPCyT O grant O PAE37143 B-AWARD and O International B-ORG Atomic I-ORG Energy I-ORG Agency I-ORG IAEA O CRPD3.10.28 B-AWARD The O International O Centre O for O Translational O Eye O Research O MAB/2019/12 O project O is O carried O out O within O the O International O Research O Agendas O programme O of O the O Foundation O for O Polish O Science O co-financed O by O the O European O Union O under O the O European B-ORG Regional I-ORG Development I-ORG Fund O V.K O is O the O awardee O of O the O fellowship O within O PASIFIC B-ORG postdoctoral I-ORG fellowship I-ORG programme I-ORG Agreement O No O PAN.BFB.S.BDN.315.022.2022 B-AWARD Project O No. O DPE/2023/00007 B-AWARD co-funded O by O the O European B-ORG Union I-ORG under I-ORG Marie I-ORG Skłodowska-Curie I-ORG CO-FUND I-ORG scheme I-ORG grant O agreement O No O 847639 B-AWARD Horizon O 2020 O ATB O received O financial O support O from O Science B-ORG Foundation I-ORG Ireland I-ORG SFI O under O Grant O SFI O 13/IF/B2791 B-AWARD in O the O context O of O an O SFI O Industry O Fellowship O Award O ATB O is O further O supported O by O the O Irish B-ORG Cancer I-ORG Society I-ORG Collaborative I-ORG Cancer I-ORG Research I-ORG Centre I-ORG BREAST-PREDICT I-ORG Grant O CCRC13GAL B-AWARD and O receives O funding O from O the O European O Union’s O Seventh B-ORG Framework I-ORG Programme I-ORG for O research O technological O development O and O demonstration O under O grant O agreement O number O 278981 B-AWARD “AngioPredict” O This O research O was O financially O supported O by O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG No. O XDA20020101 B-AWARD by O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2019M663864 O and O by O the O Western B-ORG Young I-ORG Scholar I-ORG Program-B I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG No. O 2018-XBQNXZ-B-020 B-AWARD The O primary O analysis O of O Russian O meteorological O data O was O done O with O support O of O Russian B-ORG Science I-ORG Foundation I-ORG No. O 17-77-10041 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Polish B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Higher I-ORG Education I-ORG 1268/MOB/IV/2015/0 O to O M.W.S O O Mobility O Plus O project O National B-ORG Science I-ORG Centre I-ORG 2014/15/D/NZ2/00525 O to O M.W.S O KNOW B-ORG Poznan I-ORG RNA I-ORG Centre I-ORG 01/KNOW2/2014 O The O computations O were O partially O conducted O at O the O Poznan O Supercomputing O and O Networking O Center O Funding O for O open O access O charge O Adam O Mickiewicz O University O in O Poznań O Faculty O of O Biology O This O research O was O funded O by O the O National O Science O and O Technology O Support O Program O 2013BAJ08B03 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51678475 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 2018JQ5158 O and O Scientific B-ORG Research I-ORG Program I-ORG Funded I-ORG by I-ORG Shaanxi I-ORG Provincial I-ORG Education I-ORG Department I-ORG 18JK0382 O This O research O was O funded O by O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo I-ORG FAPESP O grants O 2014/21593-2 B-AWARD and O 2020/16554-9 B-AWARD and O the O Coordination B-ORG for I-ORG the I-ORG Improvement I-ORG of I-ORG Higher I-ORG Education I-ORG Personnel—CAPES I-ORG Financial O Code O 001 B-AWARD Brazil O M.J.P.F O was O funded O by O a O fellowship O from O the O Brazilian B-ORG National I-ORG Council I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Development—CNPq I-ORG 308952/2020-0 O C.C.S O and O M.H.R O were O CNPq O fellows O in O 2017 O and O 2018 O respectively O This O study O was O co-funded O by O the O EU O via O European B-ORG Regional I-ORG Development I-ORG Fund I-ORG ERDF O POCI-01-0145-FEDER-027953 B-AWARD and O by O national O funds O via O the O Fundação B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG a I-ORG Tecnologia I-ORG FCT O project O PTDC/ASP-PES/27953/2017 B-AWARD MP-L O was O supported O by O the O FCT O under O the O Programa O Operacional O Potencial O Humano—Quadro O de O Refereência O Estratégico O Nacional O funds O from O the O European B-ORG Social I-ORG Fund I-ORG and I-ORG Portuguese I-ORG Ministério I-ORG da I-ORG Educacção I-ORG e I-ORG Ciência I-ORG IF/00764/2013 B-AWARD This O work O was O supported O by O the O project O funded O by O the O Research B-ORG Council I-ORG of I-ORG Lithuania I-ORG grant O No. O S-MIP-22-84 B-AWARD The O investigations O were O also O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2021A1515010510 O and O by O Guangzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG 202102010409 O This O study O was O supported O by O grants O from O Tri-Service B-ORG General I-ORG Hospital I-ORG TSGHC105-065 O TSGHC105-117 B-AWARD Tungs’ B-ORG Taichung I-ORG Metroharbor I-ORG Hospital I-ORG TTMHH-108R0030 O and O China B-ORG Medical I-ORG University I-ORG CMUH-104-REC2-115 O NRPB O Stroke O Clinical O Trial O Consortium O MOST O 107-2321-B-039 O 004 O and O Tungs O Taichung O Metroharbor O Hospital O TTMHH-108R0030 O This O work O is O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O under O Grant O Nos O 62165002 B-AWARD Guangxi B-ORG key I-ORG research I-ORG and I-ORG development I-ORG program I-ORG under O Grant O Nos O AB18221033 B-AWARD and O AB21075009 B-AWARD Guangxi B-ORG One I-ORG Thousand I-ORG Young I-ORG and I-ORG Middle-aged I-ORG College I-ORG and I-ORG University I-ORG Backbone I-ORG Teachers I-ORG Cultivation I-ORG Program I-ORG and I-ORG Innovation I-ORG Project I-ORG of I-ORG Guangxi I-ORG Graduate I-ORG Education I-ORG No. O YCSW2020098 B-AWARD and O Science B-ORG research I-ORG and I-ORG Technology I-ORG Development I-ORG project I-ORG of I-ORG Guilin I-ORG city I-ORG under O Grant O No. O 20210217-3 B-AWARD This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32201076 O the O Joint O Funds O of O the O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG LBZ22H180001 O LBY22H180011 B-AWARD Jiaxing B-ORG Public I-ORG Welfare I-ORG Research I-ORG Program I-ORG 2020AY30021 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81502125 B-AWARD Foundation B-ORG of I-ORG Fujian I-ORG Educational I-ORG Committee I-ORG grant O number O JK2015016 B-AWARD and O Medical B-ORG Elite I-ORG Cultivation I-ORG Program I-ORG of I-ORG Fujian O P.R.C O grant O number O 2013-ZQN-ZD-24 B-AWARD Guangdong B-ORG Provincial I-ORG Education I-ORG Department I-ORG grant O number O 2014KZDXM055 B-AWARD Guangdong B-ORG Natural I-ORG Science I-ORG Foundation I-ORG project O grant O number O 2016A070708002 B-AWARD 2016A030313003 B-AWARD Graduate B-ORG Education I-ORG Innovation I-ORG project O grant O number O 2016SFKC_42 B-AWARD YJS-SFKC-14-05 B-AWARD YJS-PYJD-17-03 B-AWARD Integration B-ORG of I-ORG cloud I-ORG computing I-ORG and I-ORG big I-ORG data I-ORG innovation I-ORG project I-ORG grant O number O 2017B02101 B-AWARD and O Jiangmen B-ORG foundation I-ORG and I-ORG theoretical I-ORG science I-ORG research I-ORG project I-ORG grant O number O 2018JC01003 B-AWARD This O work O was O supported O in O part O by O the O Beijing B-ORG Committee I-ORG of I-ORG Science I-ORG and I-ORG technology I-ORG NO. O Z141107002514088 B-AWARD the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Program O 863 O Grant O No. O 2013AA020104 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81470342 O 81400075 B-AWARD and O the O Key O Program O of O National O Natural O Science O Foundation O of O China O Grant O No. O 81230013 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No O 61902069 B-AWARD Jing O Zhang O is O the O project O leader O the O URL O of O the O project O is O as O follows:http://output.nsfc.gov.cn/fundingQuery O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG of I-ORG China I-ORG 2017J05098 O Jing O Zhang O is O the O project O leader O the O URL O of O the O project O is O as O follows:http://xmgl.fjkjt.gov.cn/p_itemsearch.pr.pr_iteminfo_public_index.do?I_ITEMID=73203&I_ITEMTYPEID=4 O and O The B-ORG Education I-ORG Department I-ORG of I-ORG Fujian I-ORG Province I-ORG science I-ORG and I-ORG technology I-ORG project I-ORG JZ160461 O Jing O Zhang O is O the O project O leader O the O URL O of O the O project O is O as O follows:http://59.77.139.101/project/project.do?actionType=view&pageModeId=view&bean.id=3639&pageFrom=commonList O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2020YFA0908700 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 62072003 O 62272004 B-AWARD 11835014 B-AWARD and O U19A2064 B-AWARD and O the O Education B-ORG Department I-ORG of I-ORG Anhui I-ORG Province I-ORG KJ2020A0047 O This O work O was O supported O by O the O Funds B-ORG for I-ORG Hebei I-ORG Distinguished I-ORG Young I-ORG Scholar I-ORG C2016204145 O the O Youth B-ORG Fund I-ORG of I-ORG Hebei I-ORG Province I-ORG Natural I-ORG Science I-ORG Foundation I-ORG C2016204157 O Green B-ORG Channel I-ORG Fund I-ORG of I-ORG Hebei I-ORG Province I-ORG Natural I-ORG Science I-ORG Foundation I-ORG C2019204308 O the O Significance B-ORG Fund I-ORG of I-ORG Hebei I-ORG Province I-ORG Natural I-ORG Science I-ORG Foundation I-ORG C2017204114 O and O the O Agricultural O University O of O Hebei O Foundation O for O Leaders O of O Disciplines O in O Science O Technology O Funds B-ORG for I-ORG Young I-ORG Talent I-ORG Project I-ORG of I-ORG Hebei I-ORG Agricultural I-ORG University I-ORG Foundation I-ORG grant O number O YJ201853 B-AWARD Funds O were O used O for O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O as O well O as O in O the O open O access O payment O This O research O was O funded O by O the O Yunnan B-ORG Provincial I-ORG Key I-ORG Science I-ORG and I-ORG Technology I-ORG Special I-ORG Project I-ORG 202102AE090027 O the O Yunling B-ORG Scholar I-ORG Program I-ORG YNWR-YLXZ-2018-026 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81860608 O and O 31560456 B-AWARD This O work O was O supported O by O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG of I-ORG China I-ORG ASTIP-IAS13 O the O Earmarked B-ORG Fund I-ORG for I-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-39 O the O National B-ORG Key I-ORG Technology I-ORG Support I-ORG Program I-ORG 2013BAI101B09 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31 O 472 I-AWARD 078 I-AWARD and O 31 B-AWARD 402 I-AWARD 041 O the O National B-ORG Key I-ORG Scientific I-ORG Instrument I-ORG and I-ORG Equipment I-ORG Development I-ORG Project I-ORG 2012YQ03026108 O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2011CB910204 O 2011CB510102 B-AWARD the O Youth B-ORG Innovation I-ORG Promotion I-ORG Association I-ORG CAS I-ORG 2 O 017 I-AWARD 325 O and O the O Genetically B-ORG Modified I-ORG Organisms I-ORG Breeding I-ORG Major I-ORG Program I-ORG of I-ORG China I-ORG 2016ZX08009-003-006 O and O 2016ZX08010-005-003 B-AWARD by O Major O Science O and O Technology O Program O of O Inner O Mongolia O Autonomous O Region O of O China O This O work O was O supported O in O part O by O following O foundations O 1) O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81372358 O 81527801 B-AWARD 2) O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province O China O 2014CFA029 O 3) O Colleges B-ORG of I-ORG Hubei I-ORG Province I-ORG Outstanding I-ORG Youth I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Team I-ORG T201305 O Above O funding O body O was O not O involved O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O study O was O funded O by O part O of O a O grant O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO. O 31571151 O and O overseas O study O was O funded O by O the O Shanghai B-ORG University I-ORG of I-ORG Sport I-ORG Graduates I-ORG stfx20160106 O for O Chenglin O Zhou O and O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG NSC O 102-2410-H-179-014-MY3 O for O Yu-Kai O Chang O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O Key B-ORG Project I-ORG of I-ORG Open I-ORG Fund I-ORG of I-ORG Shaanxi I-ORG Key I-ORG Laboratory I-ORG of I-ORG Safety I-ORG and I-ORG Durability I-ORG of I-ORG Concrete I-ORG Structures I-ORG grant O number O SZ02301 B-AWARD and O the O key B-ORG R&D I-ORG and I-ORG Achievement I-ORG Transformation I-ORG Projects I-ORG of I-ORG the I-ORG Inner I-ORG Mongolia I-ORG Autonomous I-ORG Region I-ORG 2022YFHH0118 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51678093 O were O gratefully O acknowledged O The O research O is O supported O by O grant O BK20150650 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province O China O and O grant O 31640028 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O This O work O was O supported O in O part O by O the O State’s B-ORG Key I-ORG Project I-ORG of I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG under O Grants O 2017YFC0107900 B-AWARD 2017YFC0109202 B-AWARD in O part O by O the O Fundamental O Research O Funds O for O the O Central O Universities O and O Short-term B-ORG Recruitment I-ORG Program I-ORG of I-ORG Foreign I-ORG Experts I-ORG WQ20163200398 O This O research O was O supported O by O research O grants O from O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III I-ORG PIE13/00046 O PI14/00079 I-AWARD PI14/00512 I-AWARD FI14/00269 I-AWARD CPII15/00002 I-AWARD PI17/00495 O FEDER O una O manera O de O hacer O Europa O Generalitat B-ORG Valenciana I-ORG PrometeoII/2015/017 O ACIF/2017/138 O Sociedad O Española O de O Trombosis O y O Hemostasia O and O Danish B-ORG Council I-ORG for I-ORG Independent I-ORG Research I-ORG Grant O number I-AWARD 4183-00268 O This O research O was O funded O by O the O European B-ORG Union’s I-ORG Horizon I-ORG 2020 I-ORG research I-ORG and I-ORG innovation I-ORG program I-ORG grant O agreement O GLYCO-WAY B-AWARD No I-AWARD 843950 O the O Ministry B-ORG of I-ORG Universities I-ORG the I-ORG Recovery I-ORG Transformation I-ORG and I-ORG Resilience I-ORG Plan I-ORG the I-ORG Autonomous I-ORG University I-ORG of I-ORG Madrid I-ORG UAM O CA1/RSUE/2021-00760 O the B-ORG Consejo I-ORG Nacional I-ORG de I-ORG Investigaciones I-ORG Científicas I-ORG y I-ORG Técnicas I-ORG CONICET O grant O PIP B-AWARD 2021-2023 I-AWARD and O PIBAA B-AWARD 2022-2023 I-AWARD grant O 28720210100300CO B-AWARD the O Universidad B-ORG Nacional I-ORG de I-ORG Mar I-ORG del I-ORG Plata I-ORG UNMdP O grant O UNMdP B-AWARD 15/G618-ING622/21 O and O the B-ORG Agencia I-ORG Nacional I-ORG de I-ORG Promoción I-ORG Científica I-ORG y I-ORG Tecnológica I-ORG ANPCyT O grant O PICT-2020-SERIEA-03137 B-AWARD This O work O was O supported O financially O by O 863 B-ORG National I-ORG High-Tech I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG Project O No. O 2013AA10030401 B-AWARD State B-ORG Key I-ORG Laboratory I-ORG Breeding I-ORG Base I-ORG for I-ORG Zhejiang I-ORG Sustainable I-ORG Pest I-ORG and I-ORG Disease I-ORG Control I-ORG Grant O No. O 2010DS700124-KF1712 B-AWARD and O the O Chinese B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2016M601940 B-AWARD This O research O was O funded O by O Novo B-ORG Nordisk I-ORG Foundation O grant O number O NNF14OC0009349 B-AWARD C.B O Swedish O Brain O Foundation O C.B O Swedish B-ORG Research I-ORG Council O grant O number O 2015-03100 B-AWARD C.B O Åke O Wiberg O Foundation O grant O number O M17-0088 O X.T O Fredrik B-ORG and I-ORG Ingrid I-ORG Thuring I-ORG Foundation O grant O number O 2017-00313 B-AWARD X.T O and O the O Swedish O Medical O Research O Society O X.T O This O work O was O supported O by O Prof O Hong O and O Dr. O Wang O of O the O Nanjing B-ORG Medical I-ORG Technology I-ORG Development I-ORG Project I-ORG No. O YKK14079 B-AWARD ‘Research O of O clinical O basis O and O application O of O high-risk O HPV O infection O CIN O and O cervical O cancer O related O factors’ O This O work O was O also O supported O by O Prof O Hong O of O the O Jiangsu B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG No. O BE2012606 B-AWARD ‘Care O HPV O Test O applied O to O cervical O cancer O screening O among O women O in O basic O areas O of O Jiangsu O Province’ O The O work O was O developed O by O the O cervical O cancer O screening O site O and O the O National B-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG Science I-ORG and I-ORG Education I-ORG Department I-ORG No. O 201502004 B-AWARD ‘Research O on O cervical O cancer O screening O technology O and O demonstration O for O Chinese O rural O areas’ O This O work O was O financially O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O Grant O No. O 61605128 B-AWARD Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Commission I-ORG of I-ORG Shenzhen I-ORG Grant O No. O 20180123 B-AWARD Shenzhen O science O and O technology O project O Grant O No. O JCYJ20180305124247521 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG Grant O No. O 2017A030310455 B-AWARD Start-up O Funds O for O New O Teachers O of O Shenzhen O University O Grant O No. O 2016024 B-AWARD This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81301608 B-AWARD National O Natural O Science O Foundation O of O China O No. O 81401633 B-AWARD Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O LY14H150005 B-AWARD and O Zhejiang B-ORG Provincial I-ORG Medical I-ORG Technology I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 2014KYA171 B-AWARD The O work O was O jointly O funded O by O the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No.2018YFB1600200 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.51908095 O and O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Chongqing O China O No. O cstc2019jcyj-bshX0099 B-AWARD The O funders O provided O the O funding O to O support O the O research O This O work O was O partially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81371812 O and O 81860553 B-AWARD Project B-ORG for I-ORG Innovation I-ORG Team I-ORG of I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Yunnan I-ORG Province I-ORG China I-ORG 2018HC005 O the O Medical B-ORG Leadership I-ORG Foundation I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG Yunnan I-ORG Province I-ORG China I-ORG L-201613 O and O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG China I-ORG 2018ZX10301-101 O This O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 52275288 B-AWARD Jilin B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Plan I-ORG Item I-ORG Grant O No. O 20210202021NC B-AWARD Changchun B-ORG City I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Plan I-ORG Item I-ORG Grant O No. O 21ZGN15 B-AWARD Plan B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG of I-ORG Jilin I-ORG Province I-ORG of I-ORG China I-ORG Grant O No. O 20210401139YY B-AWARD and O Project B-ORG of I-ORG Changchun I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG Grant O No. O 21ZGY02 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81200628 B-AWARD the O Chinese B-ORG Medical I-ORG Association I-ORG Clinical I-ORG Research I-ORG and I-ORG Special I-ORG Funds I-ORG I-ORG Squibb I-ORG Endocrinology I-ORG Diabetes I-ORG Research I-ORG projects I-ORG 2012 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai O China O grant O number O 12ZR1417800 B-AWARD and O the O Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Fund I-ORG grant O number O 08411953000 B-AWARD This O research O was O funded O by O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51375174 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG Central I-ORG Universities I-ORG 2017ZD024 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG S2013050014163 O 2017A030313260 B-AWARD This O research O is O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2020AAA0109701 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 62076024 O 62006018 B-AWARD Interdisciplinary B-ORG Research I-ORG Project I-ORG for I-ORG Young I-ORG Teachers I-ORG of I-ORG USTB I-ORG Fundamental O Research O Funds O for O the O Central O Universities O FRF-IDRY-21-018 B-AWARD The O authors O wish O to O thank O the O financial O support O from O the O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG No.18080503100 O Shanghai B-ORG Pujiang I-ORG Talents I-ORG Program I-ORG No.17PJC085 O Shanghai B-ORG Education I-ORG Scientific I-ORG Research I-ORG Project I-ORG No.C160030 O This O research O was O funded O by O Ministry O of O Health O under O contract O “Ricerca O Corrente O RRC-2020-23669967” O to O M.I O and O S.N O and O was O partially O supported O by O Associazione B-ORG Italiana I-ORG Ricerca I-ORG sul I-ORG Cancro I-ORG AIRC O IG B-AWARD 2016 I-AWARD N. I-AWARD 18473 O POR O Campania O FESR O 2014–2020 O “SATIN” O to O G.C O and O Earlier O Grant O to O G.C O This O project O has O received O funding O from O the O European O Union’s O Horizon O 2020 O research O and O innovation O programme O under O the O Marie O Skłodowska-Curie O grant O agreement O cONCReTE B-ORG 872391 B-AWARD PRISAR2 O 872860 O CAST B-ORG 857894 B-AWARD PAVE B-ORG 861190 B-AWARD This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31700125 O and O 81471986 O and O the O Natural B-ORG Science I-ORG Young I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province O China O LQ17H190006 O and O the O Medical B-ORG and I-ORG Health I-ORG Research I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province O China O 2017KY224 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2021YFB3700603 O the O DNL B-ORG Cooperation I-ORG Fund I-ORG CAS I-ORG DNL202012 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 52076006 O and O Foundation O from O Qinghai B-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG 2021-ZJ-912 O This O study O was O supported O by O the B-ORG Centre I-ORG for I-ORG Sino-German I-ORG Research I-ORG Promotion I-ORG Grant O Number O GZ B-AWARD 690 O the B-ORG Capital I-ORG Development I-ORG Fund I-ORG for I-ORG Medical I-ORG Research I-ORG Grant O Number O 2009-3003 B-AWARD and O the B-ORG Mental I-ORG Health I-ORG Capacity I-ORG Building I-ORG Project I-ORG by I-ORG the I-ORG National I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG Grant O Number O IHECC2013 B-AWARD MHCB O All O of O the O authors O are O independent O from O the O funders O The O funders O of O this O study O had O no O role O in O study O design O data O collection O data O analysis O data O interpretation O or O writing O of O the O manuscript O This O study O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. O LQ19E080003 B-AWARD LY17E080013 O Philosophy B-ORG and I-ORG Social I-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. O 18NDJC107YB B-AWARD Educational O Science O Planning O of O Zhejiang O Provincial O Education O Department O No. O 2018SCG103 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Ningbo I-ORG Municipality I-ORG No. O 2018A610127 B-AWARD Humanities O and O Social O Science O Research O Program O of O Ministry O of O Education O in O China O No. O 16XJCZH002 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O Number O 310823170657 B-AWARD and O 300102238501 B-AWARD The O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0300107 O and I-AWARD 2016YFD0300206 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31100125 O 31371580 I-AWARD and I-AWARD 31601251 O and O the O project O supported O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2662017QD038 O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Work O in O MR’s O laboratory O on O LMW O thiols O is O supported O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG SC3GM-100855-03 B-AWARD and O National B-ORG Science I-ORG Foundation I-ORG grant O MCB1244611 B-AWARD JMF’s O work O is O supported O by O the O U.S B-ORG Department I-ORG of I-ORG Energy O Office O of O Basic O Energy O Sciences O Division O of O Chemical O Sciences O Geosciences O and O Biosciences O Physical O Biosciences O Program O DOE O DE-FG02-05ER15650 B-AWARD to O advance O applications O of O archaea O in O bioenergy O the O National O Institutes O of O Health O NIH O R01 B-AWARD GM57498 O to O reveal O systems O important O to O human O health O through O study O of O archaea O and O the O National O Science O Foundation O MCB-1642283 O for O systems O analysis O of O archaeal O cell O biology O This O work O was O supported O in O part O by O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81571669 O 81729003 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shenzhen I-ORG JCYJ20160331185933583 O JCYJ20160531174850658 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG 2017A050501026 O 2014A030313691 O This O work O was O supported O by O a O Newcastle B-ORG University I-ORG FMS I-ORG Studentship O to O CJ, O a O BBSRC B-ORG DTP O Studentship O to O ARB O and O Royal B-ORG Society I-ORG University O Research I-AWARD Fellowship O to O YY. O The O research O activities O were O supported O by O the O Polish O National O Centre O for O Research O and O Development O Narodowe O Centrum I-ORG Badań I-ORG i I-ORG Rozwoju,https://www.ncbr.gov.pl/en O under O grant O No. O PBS/A9/23/2013 B-AWARD within O the O framework O of O the O strategic O scientific O research O and O experimental O development O programme O ZJ, O AK, O MR, O KP O the O Fondo B-ORG Nacional I-ORG de I-ORG Financiamiento I-ORG para I-ORG la I-ORG Ciencia I-ORG la I-ORG Tecnología I-ORG y I-ORG la I-ORG Innovación I-ORG Francisco I-ORG José I-ORG de I-ORG Caldas O Colombia O COLCIENCIAS,http://www.colciencias.gov.co/node/1434 O grant O FP44842-023-2015 B-AWARD AMA O the O National O Science O Centre O Poland O Narodowe O Centrum I-ORG Nauki,https://ncn.gov.pl/?language=en O under O a O grant O 2015/19/N/ST2/01679 B-AWARD KK O All O those O supporting O sources O had O no O involvement O in O study O design O collection O analysis O and O interpretation O of O data O writing O the O report O and O the O decision O to O submit O the O report O for O publication O This O study O was O supported O by O grants O from O the O Taiwan O Ministry B-ORG of I-ORG Health I-ORG and I-ORG Welfare I-ORG Clinical O Trial O and O Research O Center O of O Excellence O MOHW106-TDU-B-212-113004 O Academia B-ORG Sinica I-ORG Taiwan O Biobank O Stroke O Biosignature O Project O BM10501010037 O and O Taipei B-ORG Medical I-ORG University I-ORG TMU101-AE1-B67 O WCW O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O financially O supported O by O the O Project B-ORG of I-ORG Development I-ORG and I-ORG Research I-ORG on I-ORG Unordinary I-ORG Ornamental I-ORG Trees I-ORG 2018HX014 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31600496 O 41861017 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0500300 O and O the O Regional B-ORG Key I-ORG Program I-ORG of I-ORG the I-ORG Science I-ORG and I-ORG Technology I-ORG Service I-ORG Network I-ORG Plan I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG KFJ-STS-QYZD-044 O This O work O was O supported O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 31160208 B-AWARD 91332123 B-AWARD 81601179 B-AWARD National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2014CB846100 B-AWARD Program O for O New O Century O Excellent O Talents O in O Universities O of O China O “555 O project” O and O Scientific B-ORG Project I-ORG of I-ORG Jiangxi I-ORG Province I-ORG Grant O Nos O 20143ACB21002 B-AWARD KJLD14013 B-AWARD This O research O was O funded O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG Projects I-ORG 2019YFD1002300 O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Foundation I-ORG Fund I-ORG 2019A151511059 O Young B-ORG Talent I-ORG Support I-ORG Project I-ORG of I-ORG the I-ORG Guangzhou I-ORG Association I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG QT20220101055 O Guangdong B-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG excellent I-ORG talent I-ORG introduction I-ORG R2020YJ-YB2001 O Guangdong B-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG youth I-ORG mentor I-ORG R2020QD-031 O Research B-ORG Group I-ORG Construction I-ORG Project I-ORG of I-ORG the I-ORG Guangdong I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG 202109TD O and O Innovative B-ORG Research I-ORG Team I-ORG Construction I-ORG Project I-ORG for I-ORG Modern I-ORG Agricultural I-ORG Industry I-ORG Common I-ORG Key I-ORG Technologies I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2023KJ117 B-AWARD This O study O was O supported O by O Colciencias B-ORG Departamento O Administrativo O de O Ciencia O Tecnología O e O Innovación O Bogotá O Colombia O Project O code O number O 221356933625 B-AWARD to O BLG O Fondo O de O Investigaciones O de O la O Universidad B-ORG del I-ORG Rosario I-ORG FIUR O Bogotá O Colombia O code O DVG154 B-AWARD to O BLG O Comité O para O el O Desarrollo O de O la O Investigación O CODI O of O Universidad B-ORG de I-ORG Antioquia I-ORG through O the O Sustainability B-AWARD Strategy I-AWARD Program I-AWARD 2016-2017 I-AWARD and O the O Mycotic O Diseases O Branch O CDC O Atlanta O USA O and O the O IMMY O Company O Norman O Oklahoma O USA O for O a O travel O grant O for O the O student O supporting O our O project O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81703896 B-AWARD 81673776 B-AWARD Beijing B-ORG municipal I-ORG science I-ORG and I-ORG technology I-ORG commission I-ORG No. O Z171100001017209 B-AWARD and O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFC0108102 B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 31630088 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31501051 O the B-ORG Science I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG 16142202600 O Shanghai B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG 201740023 O and O the B-ORG “Fostering I-ORG Project I-ORG for I-ORG Outstanding I-ORG Young I-ORG Talent” I-ORG from I-ORG Tongji I-ORG University I-ORG 2015KJ054 O This O study O was O supported O by O a O NSFC B-ORG grant O 31971108 O 81741016 O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017A020214015 O and O the B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG 201710010054 O Supported O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81800474 O Zhejiang B-ORG Natural I-ORG Science I-ORG Foundation I-ORG LY18H030006 O and O Zhejiang B-ORG Province I-ORG Education I-ORG Department I-ORG Foundation I-ORG Y201738056 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 62201349,61731020 O and O 61988102 B-AWARD the O 111 B-ORG Project I-ORG D18014 O the O Key O project O supported O by O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG Shanghai I-ORG Municipality I-ORG YDZX20193100004960 O and O the O General B-ORG Administration I-ORG of I-ORG Customs I-ORG Project I-ORG 2020hk251 O FEDER O through O COMPETE O by O National O funds O through O FCT O – O Fundação B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG a I-ORG Tecnologia I-ORG under O the O Project O PTDC/SAU-GMG/111761/2009 B-AWARD Norte-01-0145-FEDER-000008 B-AWARD – O Porto O Neurosciences O and O Neurologic O Disease O Research O Initiative O at O I3S O supported O by O Norte B-ORG Portugal I-ORG Regional I-ORG Operational I-ORG Programme I-ORG NORTE I-ORG 2020 O under O the O PORTUGAL O 2020 O Partnership O Agreement O through O the O European O Regional O Development O Fund O ERDF O and O Wellcome B-ORG Trust I-ORG 092071/Z/10/Z O to O A.P.M O Z.M O and O A.V.-B O and O Core B-AWARD Award I-AWARD 090532/Z/09/Z O F.F O is O a O FCT O fellow O SFRH/BD/72927/2010 O and O P.B O a O FCT O Investigator O This O work O was O supported O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG grant O O R01NS085122 B-AWARD ET) O and O grant O O R01HD53801 B-AWARD SA O National B-ORG Institute I-ORG on I-ORG Disability I-ORG Independent I-ORG Living I-ORG and I-ORG Rehabilitation I-ORG Research I-ORG grant O O 90RE5021 B-AWARD SA) O National B-ORG Science I-ORG Foundation I-ORG grant O O CBET-1804550 B-AWARD ET O and O the O Global O Resilience O Institute O at O Northeastern O University O This O research O was O funded O by O “Education O Department I-ORG Research I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG Grant O No. O 21B0170)” B-AWARD “the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG of I-ORG China I-ORG Grant O No. O 2021JJ40540)” B-AWARD “Guangdong O Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG grant O No. O 2019A1515111032)” B-AWARD “National O Natural I-ORG Science I-ORG Foundation I-ORG grant O No. O 52008107)” B-AWARD and O “the O Special B-ORG Funds I-ORG for I-ORG the I-ORG Construction I-ORG of I-ORG Innovative I-ORG Provinces I-ORG in I-ORG Hunan I-ORG China I-ORG Nos O 2019RS1059)” O This O research O was O funded O by O University B-ORG of I-ORG Sharjah I-ORG CoV-19 O grant O number O 0304 B-AWARD MBRU-AlMahmeed B-ORG Research I-ORG Award-ALM O grant O number O 1914 B-AWARD and O University B-ORG of I-ORG Sharjah I-ORG Collaborative I-ORG Grant O number O 2001090279 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 51306136 B-AWARD and O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation O grant O number O 2018M643639 B-AWARD and O was O partially O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province O China O Research O Project O 2016JQ5114 B-AWARD This O study O was O funded O by O Shanghai B-ORG Education I-ORG Development I-ORG Foundation I-ORG and I-ORG Shanghai I-ORG Municipal I-ORG Education I-ORG Commission I-ORG 16SG32 O China O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG 16ZR1436900 O China O Youth B-ORG Program I-ORG of I-ORG Medical I-ORG Science I-ORG and I-ORG Technology I-ORG 16QNP093 O China O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31901354 O Beijing B-ORG Innovation I-ORG Consortium I-ORG of I-ORG Agriculture I-ORG Research I-ORG System I-ORG BAIC09-2022 O and O the O Innovation B-ORG Foundation I-ORG of I-ORG the I-ORG Beijing I-ORG Academy I-ORG of I-ORG Agriculture I-ORG and I-ORG Forestry I-ORG Sciences I-ORG KJCX20200112 O The O work O described O in O this O article O was O funded O by O the O German B-ORG Federal I-ORG Ministry I-ORG of I-ORG Education I-ORG and I-ORG Research I-ORG grant O agreement O no. O 031B0731E B-AWARD and O 031B0731G B-AWARD as O part O of O the O joint O project O “Food4future” O in O the O BMBF O initiative O “Agricultural O systems O of O the O future” O Funded O by O the O Deutsche B-ORG Forschungsgemeinschaft I-ORG DFG O German O Research O Foundation)—491394008 O This O research O was O partly O funded O by O the O Federal B-ORG Ministry I-ORG of I-ORG Education I-ORG and I-ORG Research I-ORG within I-ORG the I-ORG projects I-ORG iCampus I-ORG grant O agreement O no. O 16ES1132 B-AWARD and O 16ME0425 B-AWARD and O “Forschungsfabrik O Mikroelektronik I-ORG Deutschland I-ORG FMD)” O grant O agreement O no. O 16FMD02 B-AWARD This O work O was O supported O by O a O project O of O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG China I-ORG grant O No. O SQ2017YFSF090013 B-AWARD a O subproject O of O the O National O Key O Research O and O Development O Project O of O China O grant O No.2017YFC0907203 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O No.82160640 O and O Public O Health O and O Preventive O Medicine-Specialties O of O Higher B-ORG Education I-ORG Institutions I-ORG in I-ORG Xinjiang I-ORG Uygur I-ORG Autonomous I-ORG Region I-ORG in O the O 14th O Five-Year O Plan O grant O No. O New B-AWARD Education I-AWARD Letter I-AWARD 2022 I-AWARD No. I-AWARD 112 O The O sponsors O did O not O play O any O role O in O the O study O design O in O the O collection O analysis O and O interpretation O of O data O in O the O writing O of O this O report O or O in O the O decision O to O submit O the O article O for O publication O Funding O for O this O work O was O provided O by O Tufts B-ORG University I-ORG Department B-AWARD of I-AWARD Civil I-AWARD and I-AWARD Environmental I-AWARD Engineering O Tufts B-AWARD Institute I-AWARD of I-AWARD the I-AWARD Environment O the O National B-ORG Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute I-ORG P01 O AG023394 B-AWARD and O P50 B-AWARD HL105185 O the O National B-ORG Institute I-ORG of I-ORG Environmental I-ORG Health I-ORG Sciences I-ORG ES015462 O the O National B-ORG Science I-ORG Foundation I-ORG 0966093 O and O a O Philanthropic O Educational O Organization O Esther O Garrett O Edgerton O Endowed O Scholar O Award O No O funder O had O any O role O in O the O design O of O the O study O collection O of O the O data O analysis O of O the O data O interpretation O of O the O results O or O writing O the O manuscript O The O BEST3 O study O is O funded O by O Cancer B-ORG Research I-ORG UK I-ORG as O the O primary O funder O covering O research O costs O Part O A) O Grant O no O C14478/A21047 B-AWARD and O the O NIHR O covering O service O support O costs O and O research O costs O Part O B). O NHS O commissioners O fund O excess O treatment O costs O in O relevant O regions O and O Medtronic O provide O funding O for O Cytosponge O devices O and O TFF3 O antibodys O BM, O AW, O IDB O and O ZK O are O funded O as O part O of O the O BEST3 O CRUK O grant O no O C14478/A21047 O PS, O FP O and O JO O are O supported O by O the O Cancer O Research O UK O programme O grant O C8161/A16892 O IK O and O BA O are O supported O by O the O CRUK O Cancer O Prevention O Trials O Unit O programme O grant O C8162/A16893 O SGS O is O supported O by O a O Cancer O Research O UK O Postdoctoral O fellowship O C42785/A17965 O RCF O and O MOD O are O funded O by O an O MRC O Programme O Grant O grant O no O RG84369 B-AWARD CJ O is O funded O by O the O Medical B-ORG Research I-ORG Council I-ORG grant O code O U105260566 B-AWARD SM O is O funded O by O the O HEFCE O FMW O is O supported O by O a O Clinician O Scientist O award O RG O 68235 O from O the O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG NIHR O The O Human O Research O Tissue O Bank O is O supported O by O the O NIHR O Cambridge O Biomedical O Research O Centre O This O study O was O funded O by O the O projects O CGL2015-65055-P B-AWARD and O CGL2015-64650-P B-AWARD from O the O Spanish B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Innovation I-ORG and O P11-RNM-7038 B-AWARD and O IB16121 B-AWARD from O the O Junta B-ORG de I-ORG Andalucía I-ORG and O Junta B-ORG de I-ORG Extremadura O MF O was O funded O by O a O Juan B-ORG de I-ORG la I-ORG Cierva I-ORG 2017 I-ORG Formación I-ORG contract O FJCI-2017-34394 O from O the O Ministry O of O Science O Innovation O and O Universities O LGL O was O supported O by O a O postdoctoral O grant O from O Junta O de O Extremadura O PO17024 O JMP O was O partially O supported O by O a O 2017 O Leonardo B-ORG Grant I-ORG for I-ORG Researchers I-ORG and I-ORG Cultural I-ORG Creators O BBVA B-AWARD Foundation O The O Foundation O accepts O no O responsibility O for O the O opinions O statements O or O contents O of O this O project O and/or O the O results O thereof O which O are O entirely O the O responsibility O of O the O authors O This O project O was O supported O by O grant O W81XWH-09-1-0689 B-AWARD BC085882 O WGH O from O the O Department B-ORG of I-ORG Defense I-ORG Breast I-ORG Cancer I-ORG Research I-ORG Program O grant O P50AT006268 B-AWARD WGH O UTI O RTT O from O the O National B-ORG Center I-ORG for I-ORG Complementary I-ORG and I-ORG Integrative I-ORG Health I-ORG NCCIH O the O Office O of O Dietary O Supplements O ODS O and O the O National O Cancer O Institute O NCI O and O grant O P30 B-AWARD ES000210 I-AWARD CL) O from O the O National B-ORG Institute I-ORG of I-ORG Environmental I-ORG Health I-ORG Sciences I-ORG NIEHS O Its O contents O are O solely O the O responsibility O of O the O authors O and O do O not O necessarily O represent O the O official O views O of O the O NCCIH O ODS O NCI O NIEHS O or O the O National O Institutes O of O Health O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O number O 2016YFC0900603 B-AWARD the O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG grant O number O 7172023 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81973121 B-AWARD and O 81373076 B-AWARD and O the O Importation B-ORG and I-ORG Development I-ORG of I-ORG High-Caliber I-ORG Talents I-ORG Project I-ORG of I-ORG Beijing I-ORG Municipal I-ORG Institutions I-ORG grant O number O CIT&TCD201504088 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG ZR2019MH093 O the B-ORG National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81902905 O the O National O Natural O Science O Foundation O of O China O No.32161143036 O and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2021YFC2300800 B-AWARD 2021YFC2300803 B-AWARD The O funding O body O had O no O role O in O the O design O of O the O study O data O collection O and O analysis O interpretation O of O data O or O in O writing O the O manuscript O The O study O was O supported O by O following O findings O The O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81641169 O 81771887 I-AWARD 81901712 I-AWARD and I-AWARD 81771897 O used O for O study O design O and O patients O collection O Program B-ORG for I-ORG New I-ORG Century I-ORG Excellent I-ORG Talents I-ORG in I-ORG University I-ORG No: O NCET-13-0386 I-AWARD used O for O data O analysis O Applied B-ORG basic I-ORG research I-ORG program I-ORG of I-ORG science I-ORG and I-ORG technology I-ORG commission I-ORG foundation I-ORG of I-ORG Sichuan I-ORG Province I-ORG of O China O 2017JY0027 O and O Program B-ORG for I-ORG Young I-ORG Scholars I-ORG and I-ORG Innovative I-ORG Research I-ORG Team I-ORG in I-ORG Sichuan I-ORG Province I-ORG of O China O 2017TD0005 O used O for O language O editing O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61975022 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2022CDJJMRH-005 O the O Chongqing B-ORG Talents I-ORG Exceptional I-ORG Young I-ORG Talents I-ORG Project I-ORG CQYC202005011 O and O the O National B-ORG Science I-ORG Fund I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG 61825501 O Conicyt-PIA B-ORG program I-ORG grant O No O ACT1108 B-AWARD ACC O acknowledges O support O from O Beca B-ORG Doctorado I-ORG Nacional I-ORG 21120617 B-AWARD MK O acknowledges O to O Fondap B-ORG 15130011 B-AWARD and O Fondecyt B-ORG 1130425 B-AWARD JRM O acknowledges O support O from O Conicyt-Fondecyt B-ORG program O grant O No O 1141185 B-AWARD No O 1180673 O and O AFOSR B-ORG grant I-ORG No O FA9550-15-1-0113 B-AWARD and O FA9550-16-1-0384 B-AWARD JA O acknowledges O support O from O Fondecyt O grant O 3150587 B-AWARD ARA O acknowledges O support O from O Fondecyt O grant O 1161065 B-AWARD and O Basal B-ORG Funding I-ORG CONICYT-PFB-12/2007 O CARE I-AWARD This O study O is O partially O supported O by O the B-ORG program I-ORG of I-ORG the I-ORG China I-ORG Scholarship I-ORG Council I-ORG No. O 202008410082 B-AWARD the B-ORG National I-ORG Social I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O grant O 21BGL052 B-AWARD the B-ORG Zhengzhou I-ORG Science I-ORG and I-ORG Technology I-ORG Collaborative I-ORG Innovation I-ORG Project I-ORG 21ZZXTCX27 O BHF B-ORG UK I-ORG AA/18/3/34220 O Royal B-ORG Society I-ORG UK I-ORG RP202G0230 O MRC B-ORG UK I-ORG MC_PC_17171 O Hope B-ORG Foundation I-ORG for I-ORG Cancer I-ORG Research I-ORG UK I-ORG RM60G0680 O Sino-UK B-ORG Industrial I-ORG Fund I-ORG UK I-ORG RP202G0289 O GCRF B-ORG UK I-ORG P202PF11 O LIAS B-ORG UK I-ORG P202ED10 O P202RE969 B-AWARD Data B-ORG Science I-ORG Enhancement I-ORG Fund I-ORG UK I-ORG P202RE237 O Fight B-ORG for I-ORG Sight I-ORG UK I-ORG 24NN201 O Sino-UK B-ORG Education I-ORG Fund I-ORG UK I-ORG OP202006 O and O BBSRC B-ORG UK I-ORG RM32G0178B8 O This O study O was O funded O by O grants O from O the B-ORG National I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No: O 81670055,81670056,91442103 B-AWARD 81500052 B-AWARD and O 81570057 B-AWARD Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG the I-ORG People’s I-ORG Republic I-ORG of I-ORG China I-ORG 2016YFC1100200 O 2016YFC1100204 B-AWARD the B-ORG Health I-ORG Bureau I-ORG Program I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG SHDC12014120 O and O 2013SY047 B-AWARD and O Tongji B-ORG University I-ORG 1511219020 O This O work O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O No. O 11874270 B-AWARD Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG under O Grant O No. O 2022A1515011389 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O China O under O Grant O No. O 2015A030313551 B-AWARD and O the O Fund B-ORG Project I-ORG for I-ORG Shenzhen I-ORG Fundamental I-ORG Research I-ORG Program I-ORG under O Grant O No. O JCYJ20190808143409787 B-AWARD All O the O samples O in O this O article O are O from O Sixcarbon O Tech O Shenzhen O China O The O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O 81570750 B-AWARD and O 81870575 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG for I-ORG Young I-ORG Scholars I-ORG of I-ORG China I-ORG grant O 81700718 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG grants O 2017A030310044 B-AWARD 2017A030310199 B-AWARD and O 2019A1515010992 B-AWARD National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG grant O 2016YFC0906101 B-AWARD Operational B-ORG Grant I-ORG of I-ORG Guangdong I-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG grant O 2017B030314019 B-AWARD Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG grant O 2017A050503003 B-AWARD and O Guangzhou B-ORG Municipal I-ORG Program I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG grant O 201704020167 B-AWARD all O supplied O the O funds O for O the O establishment O of O peritoneal O dialysis O database O collection O of O follow-up O data O and O detection O of O blood O The O funders O played O no O role O in O study O design O data O collection O analysis O interpretation O or O manuscript O writing O This O research O was O funded O by O Ministry B-ORG of I-ORG Health I-ORG and I-ORG Welfare O MOHW108-TDU-B-212-124010 O to O A.L.Y O T.-T.W O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG MOST O 108-2314-B-038-061-MY3 I-AWARD to O T.-T.W O Taipei B-ORG Medical I-ORG University I-ORG Hospital I-ORG 107TMU-TMUH-06 O 108TMU-TMUH-09 B-AWARD to O T.-T.W O This O research O was O supported O by O NIH B-ORG grants O 1R01AR073004-01A1 O and O R01AR071189-01A1 B-AWARD and O R21 B-AWARD AI149267-01A1 O the O VA B-ORG merit I-ORG grant O 1I01BX004293-01A1 O and O a O DOD B-ORG grant O W81XWH2210689 O awarded O to O A.T.S O This O research O was O financially O supported O by O The O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51675518 B-AWARD Six B-ORG Talent I-ORG Peaks I-ORG Project I-ORG in I-ORG Jiangsu I-ORG Province I-ORG No. O JXQC-008 B-AWARD China B-ORG Scholarship I-ORG Council I-ORG No. O 201706425041 B-AWARD the O Priority O Academic O Program O Development O of O Jiangsu O Higher O Education O Institutions O and O Qing O Lan O Project O in O Jiangsu O Province O This O work O was O supported O by O the O National B-ORG Science I-ORG Center O Poland O grant O number O 2016/21/D/ST5/01641 B-AWARD R.M O and O D.H O acknowledge O the O EU’s B-ORG Horizon I-ORG 2020 I-ORG for O funding O the O OCTA O project O under O grant O agreement O No. O 778158 B-AWARD Research O work O was O supported O by O the O funds O for O science O in O 2018–2023 O allocated O to O the O implementation O of O an O international O cofinanced O project O by O the O Polish O Ministry O of O Education O and O Science O ABG O acknowledges O Silesian B-ORG University I-ORG of I-ORG Technology I-ORG for O the O financial O support O provided O under O the O Rector’s O pro-quality O grant O No. O 04/040/RGJ23/0239 B-AWARD This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 216YFD0500402 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31472208 B-AWARD 31702238 B-AWARD and O the B-ORG Jilin I-ORG Scientific I-ORG and I-ORG Technological I-ORG Development I-ORG Program I-ORG Grant O No. O 20180520039JH B-AWARD XHL O received O funds O for O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG Grant O No. O 15ZR1444300.http://www.stcsm.gov.cn/sj/app.htm B-AWARD RDM O was O in O receipt O of O grant O 2014/09361-9 B-AWARD from O the O São O Paulo O Research O Foundation O FAPESP,http://www.fapesp.br O WCB O received O funds O from O CAPES B-ORG Special O Visiting O Reseacher O Program O Grant O 170/2012 B-AWARD that O enabled O RAW O to O work O in O his O laboratoryhttp://www.capes.gov.brand O a O Newton B-ORG Fund I-ORG grant O APQ-00829-15 B-AWARD through O the O BBSRC/Fapemig O joint O initiative O held O with O PDA O and O Prof O R O Beynon O Liverpool O University O http://www.newtonfund.ac.uk O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O Innovative B-ORG Medical I-ORG Research I-ORG IMF I-ORG of I-ORG the I-ORG Medical I-ORG Faculty I-ORG of I-ORG the I-ORG University I-ORG of I-ORG Münster I-ORG SC221502 O ASP O received O a O research O grant O of O the O Interdisciplinary B-ORG Center I-ORG for I-ORG Clinical I-ORG Research I-ORG IZKF I-ORG of I-ORG the I-ORG Medical I-ORG Faculty I-ORG of I-ORG the I-ORG University I-ORG of I-ORG Münster I-ORG SEED07 O ASP O received O a O research O grant O of O the O Cluster B-ORG of I-ORG Excellence I-ORG “Cells I-ORG in I-ORG Motion” I-ORG CIM I-ORG of I-ORG the I-ORG University I-ORG of I-ORG Münster I-ORG CIM-PP-2017-06 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the B-ORG Youth I-ORG Science I-ORG Foundation I-ORG of I-ORG Guangxi I-ORG Medical I-ORG University O Grant/Award O Numbers O GXMUYFY201712 B-AWARD Guangxi B-ORG Young I-ORG and I-ORG Middle-aged I-ORG Teacher’s I-ORG Basic I-ORG Ability I-ORG Promoting I-ORG Project O Grant/Award O Number O 2019KY0119 B-AWARD and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O Grant/Award O Numbers O 81560359 B-AWARD 81860393 B-AWARD This O research O was O funded O by O the O Science O Fund O of O the O State O Key O Laboratory O of O Engine O Reliability O Grant O Number O skler-201714 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG program O Grant O Number O 2017YFC0211302 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O Grant O Number O 21676195 B-AWARD the O National O Natural O Science O Foundation O of O China O for O Youths O Grant O Number O 21908207 O and O the O Shanxi B-ORG Province I-ORG Science I-ORG Foundation I-ORG for I-ORG Youths O Grant O Number O 201901D211224 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81671589 O and O 81601400 B-AWARD the O Shanghai B-ORG Sailing I-ORG Program I-ORG 16YF1407000 O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG 2014CB541801 O and O International B-ORG S&T I-ORG Cooperation I-ORG Program I-ORG of I-ORG China I-ORG 2013DFA30870 O The O funding O bodies O had O no O role O in O the O study O design O data O collection O or O analyses O decision O to O publish O or O preparation O of O this O manuscript O This O work O was O financially O supported O by O grants O from O the B-ORG National I-ORG Technical I-ORG System I-ORG of I-ORG Watermelon I-ORG and I-ORG Melon I-ORG Industry I-ORG CARS-25 O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0100705 O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2018LC017 O and O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG Shandong I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG CXGC2018E08 O This O project O was O financially O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31570601 B-AWARD the O open O project O of O Ecological B-ORG Security I-ORG and I-ORG Protection I-ORG Key I-ORG Laboratory I-ORG of I-ORG Sichuan I-ORG Province I-ORG ESP1502 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0502505 O and I-AWARD 2017YFC0505003 O and O the O Key B-ORG Program I-ORG of I-ORG Sichuan I-ORG Education I-ORG Department I-ORG 17ZA0321 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O ASM O was O funded O by O Wellcome B-ORG Trust I-ORG Masters O Fellowship O in O Public O Health O and O the O Association O of O Physicians O of O Great O Britain O and O Ireland O which O fund O this O research O Grant O Number O 106356/Z/14/Z B-AWARD EPAB O was O funded O by O the O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG CAPES O Grant O 88881.133584/2016-01 B-AWARD and O AEE O funded O by O the O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG of O the O Ministério O da O Ciência O Tecnologia O e O Inovação O CNPq/MCTI O Grant O 310205/2014-0 B-AWARD and O Fundação O de O Amparo O à O Pesquisa O do O Estado O de O Minas O Gerais O FAPEMIG O Grant O PPM-00502-15 O FOO O was O also O supported O by O a O Wellcome O Trust O Intermediate O Research O Fellowship O Grant O Number O WT102350/Z/13/Z B-AWARD a O Howard O Hughes O Medical O Institute O HHMI)—Gates O International O Research O Scholarship O Grant O No. O OPP1175877 O and O a O Bill O O Melinda O Gates O Foundation O Grant O Grant O No. O OPP1177156 O This O study O was O supported O by O the O funds O from O the O “Zhongshan O Development I-ORG Program” O Recruitment O Grant O No. O 016 B-AWARD the O National B-ORG Science I-ORG Fund I-ORG for I-ORG Young I-ORG Scholars I-ORG Grant O No. O 81402142 B-AWARD and O the O Chinese B-ORG Anti-Cancer I-ORG Association I-ORG Grant O No. O HYXH1002 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China O grant O number O 2017YFD0500101 B-AWARD the O China O Association O for O Science O and O Technology O Youth O Talent O Lift O Project O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province O grant O number O BK20170721 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for O the O Central O Universities][grant O number O Y0201600147 B-AWARD and O the O Priority O Academic O Program O Development O of O Jiangsu O Higher O Education O Institutions O Thsi O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China(31670716)-No O to O WL; O the O China B-ORG Postdoctoral I-ORG Science I-ORG Special I-ORG Foundation I-ORG 2016T90044)-No O to O DX O and O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2015M570945)-No O to O DX. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O project O has O received O funding O from O the O European B-ORG Research I-ORG Council I-ORG ERC O under O the O European O Union’s O Horizon O 2020 O research O and O innovation O programme O Grant O Agreement O No. O 680040 B-AWARD the O Hungarian O Brain O Research O Program O 2017-1.2.1-NKP-2017-00002 O the O BIAL B-ORG Foundation I-ORG grant O no O 169/16 B-AWARD the O National O Research O Development O and O Innovation O Office O OTKA O FK O 128242 O K O 132372 O the O Hungarian B-ORG Academy I-ORG of I-ORG Sciences I-ORG F01/031 O the O János O Bolyai O Research O Scholarship O of O the O Hungarian O Academy O of O Sciences O and O the O EFOP-3.62.-NEUR-I-H O and O NEUR-II-H O grants O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No.41325010 O the O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2013CB956703 B-AWARD and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No. O 2652013055 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O byInstituto O de I-ORG Salud I-ORG Carlos I-ORG III10.13039/501100004587grantsPI18/00147andPI18/01319;Ministerio O de I-ORG Educación I-ORG Cultura I-ORG y I-ORG Deporte10.13039/501100003176grantFPU‐PhD O fellowship I-AWARD FPU I-AWARD 15/00964;Spanish O Foundation O per O Amor O a O l`Art O FPAA)grant O Fundació O la I-ORG Marató I-ORG de I-ORG TV310.13039/100008666grants20143130and20143131;Generalitat O Valenciana10.13039/501100003359grantsOP O ERDF I-AWARD of I-AWARD Comunitat I-AWARD Valenciana I-AWARD 2014‐2020andPROMETEO/2018/135 O The O study O was O supported O by O theWellcome O Trustthrough O a O Centre O Grant O no. O 98,461/Z/12/Z B-AWARD “The O University O of O Oxford O Sleep O and O Circadian O Neuroscience O Institute O SCNi)” O This O work O was O also O funded O by O a O Wellcome O Trust O Strategic O Award O CONBRIO O Collaborative O Oxford O Network O for O Bipolar O Research O to O Improve O Outcomes O Reference O number O 102,616/Z B-AWARD NP O and O MO O acknowledge O the O support O of O theRCUK O Digital I-ORG Economy I-ORG ProgrammeGrant O number O EP/G036861/1 B-AWARD Oxford O Centre O for O Doctoral O Training O in O Healthcare O Innovation O This O research O was O funded O by O the O Program O of O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O U1937204 B-AWARD and I-AWARD No. I-AWARD 51905124 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O Nos I-AWARD HIT I-AWARD NSRIF I-AWARD 2020003 O and O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2019M661278 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31460286 B-AWARD 31660307 B-AWARD 31260252 B-AWARD 31330038 B-AWARD the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Xizang I-ORG Tibet I-ORG Autonomous I-ORG Region I-ORG No. O Z2014A09G2-3 B-AWARD the B-ORG Innovation I-ORG Support I-ORG Program I-ORG for I-ORG Young I-ORG Teachers I-ORG of I-ORG Tibet I-ORG Autonomous I-ORG Region I-ORG No. O QCZ2016-27 B-AWARD QCZ2016-29 B-AWARD QCZ2016-34 B-AWARD and O the B-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG Project I-ORG of I-ORG Tibet I-ORG Autonomous I-ORG Region I-ORG No. O 2016ZR-MQ-06 B-AWARD 2015ZR B-AWARD 13-19 O This O work O was O funded O by O the O Luxembourgish B-ORG Ministry I-ORG of I-ORG Research I-ORG project O Marlybor O REC-LNSI-20110308 B-AWARD Wibke O J. O Cramaro O was O supported O by O a O fellowship O from O Aides O à O la O Formation O Recherche O grant O n° O 4660265 B-AWARD of O the O Fonds B-ORG National I-ORG de I-ORG la I-ORG Recherche I-ORG Luxembourg O Lesley O Bell-Sakyi O was O supported O by O the O United O Kingdom O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG grant O BBS/E/1/00001741 B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81972139 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG grant O number O 19ZR1432800 B-AWARD and O the O Program B-ORG for I-ORG improving I-ORG the I-ORG Clinical I-ORG Scientific I-ORG Research I-ORG ability I-ORG of I-ORG Postgraduate I-ORG students I-ORG in I-ORG Pediatrics I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG School I-ORG of I-ORG Medicine I-ORG EKKY2018005DGD O This O study O was O funded O by O PLA B-ORG Logistics I-ORG Research I-ORG Program I-ORG BWS14J025 O PLA B-ORG Medical I-ORG Science I-ORG Youth I-ORG Training I-ORG Project I-ORG 14QNP057 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81301445 O the B-ORG 12th I-ORG Five I-ORG Years I-ORG Major I-ORG Special I-ORG Projects I-ORG of I-ORG Chinese I-ORG PLA I-ORG AWS11L009 O and O Open B-ORG Research I-ORG Fund I-ORG Program I-ORG of I-ORG Shanghai I-ORG Key I-ORG Laboratory I-ORG of I-ORG Medical I-ORG Biodefense I-ORG SKLM1401 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O project O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81472027 O to O SKW O Key B-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG of I-ORG Nanjing I-ORG Medicine I-ORG ZDX16001 O and O Innovation B-ORG team I-ORG of I-ORG Jiangsu I-ORG provincial I-ORG health-strengthening I-ORG engineering I-ORG by I-ORG science I-ORG and I-ORG education I-ORG CXTDB2017008 O to O SKW O This O project O was O also O supported O by O grants O from O Jiangsu B-ORG Youth I-ORG Medical I-ORG Talents I-ORG Training I-ORG Project I-ORG to O B.H(QNRC2016066 O and O Y.P O QNRC2016074 O and O Nanjing B-ORG Medical I-ORG Science I-ORG and I-ORG Technique I-ORG Development I-ORG Foundation I-ORG to O BSH O No. O JQX13003 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31660253 O to O XJ O the O Scientific B-ORG and I-ORG Technological I-ORG Foundation I-ORG of I-ORG Hainan I-ORG Province I-ORG HNGDhs201502 O to O XJ O the B-ORG Foundations I-ORG of I-ORG Hainan I-ORG University I-ORG and O Shandong O Normal O University O hdkytg201706 O to O XJ O and O JS O and O Startup B-ORG funding I-ORG from I-ORG Hainan I-ORG University I-ORG KYQD(ZR)1845 O to O YZ O The O above O funding O was O used O for O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O in O writing O the O manuscript O This O research O was O funded O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O 2017YFA0505103 B-AWARD NSFC B-ORG 21877068 O the B-ORG Chinese I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2020YFC2002705 O and O 2014CBA02005 O This O work O was O supported O by O the O Tianjin B-ORG Municipal I-ORG Natural I-ORG Science I-ORG Foundation I-ORG 16JCZDJC36100 O Medical B-ORG and I-ORG Health I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG Chinese I-ORG Academy I-ORG Medical I-ORG Sciences I-ORG 2017-I2M-1-016 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 3332018116 O This O study O was O financially O supported O by O the O Academy B-ORG of I-ORG Finland I-ORG 264944 B-AWARD the O Swedish O Research O Council O for O Health O for O Working O Life O and O Welfare O 2007–1762 O and O 2009–1758 O and O the O UK B-ORG Economic I-ORG and I-ORG Social I-ORG Research I-ORG Council I-ORG ES/K01336X/1 O under O the O ERA-AGE2 B-AWARD initiative O S.S O is O supported O by O the O Academy O of O Finland O 286294 O and I-AWARD 294154 O and O M.K O is O supported O by O the O MRC B-ORG K013351 O NordForsk O and O the O ESRC O This O work O was O supported O by O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2015CB150502 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD020010X O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31172032 O This O work O was O supported O by O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III/Subdirección I-ORG General I-ORG de I-ORG Investigación I-ORG Sanitaria I-ORG Fondo I-ORG de I-ORG Investigación I-ORG en I-ORG Salud I-ORG proyect O PI17/02283 B-AWARD Red B-ORG de I-ORG terapia I-ORG celular I-ORG TERCEL O RD16/0011/0035 O and O RICORS B-ORG RD21/0017/0016 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 21572027 B-AWARD and O 21372267 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 10611201CDJXY460001 O and O Startup B-ORG Funds I-ORG for I-ORG Young I-ORG Scientists I-ORG in I-ORG Chongqing I-ORG University I-ORG 0236011104411 O This O work O was O supported O byChina O National I-ORG Key I-ORG Basic I-ORG Research I-ORG Program(2014CB954201),National O Key I-ORG R I-ORG I-ORG D I-ORG Programof O China O 2017YFC0803803),National O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China(No O 31300186 B-AWARD Key O Laboratory O of O Forensic O Marks O of O Ministry O of O Public O Security O Institute O of O Forensic O Science O Ministry O of O Public O Security O of O China O No. O 2014FMKFKT02 O the O Open O Project O Program O of O theState O Key I-ORG Laboratory I-ORG of I-ORG Systematic I-ORG and I-ORG Evolutionary I-ORG Botany(LSEB O 2016-01 O of O China O and O theChinese O Academy I-ORG of I-ORG Sciences I-ORG President's I-ORG International I-ORG Fellowship I-ORG Initiative(Nos O 2016VBC063 B-AWARD and O 2018VBA0016 B-AWARD This O research O was O funded O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC0705604 O Key B-ORG Laboratory I-ORG of I-ORG Structures I-ORG Dynamic I-ORG Behavior I-ORG and I-ORG Control I-ORG Ministry I-ORG of I-ORG Education I-ORG in I-ORG Harbin I-ORG Institute I-ORG of I-ORG Technology I-ORG HITCE201707 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 51878118 O and O the O project O DEC B-AWARD 2017/25/B/ST8/01800 I-AWARD of O the O National O Science O Centre O Poland O This O research O was O supported O by O the O National B-ORG Key I-ORG R I-ORG I-ORG D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0901302 O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31472275 O Modern B-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG CARS-48 O The B-ORG program I-ORG of I-ORG Shandong I-ORG Leading I-ORG Talent I-ORG LNJY2015002 O and O Qingdao O Industrial O Development O Program O Science O and O Technology O Benefit O Special O Project O 17–3–3-62-nsh O The O funding O body O of O Dr. O Jitao O Li O designed O this O study O and O wrote O the O manuscript O The O funding O body O of O Prof O Jian O Li O built O and O collected O the O Backcross O families O for O genetic O linkage O map O construction O This O work O was O supported O by O the B-ORG Research I-ORG Project I-ORG of I-ORG Tianjin I-ORG Medical I-ORG University I-ORG No. O 2014KYM04 B-AWARD the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Tianjin I-ORG 13JCZDJC30000 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31101039 O 31771093 O and O 31370891 B-AWARD This O work O was O supported O by O National B-ORG Magnetic I-ORG Confinement I-ORG Fusion I-ORG Energy I-ORG Research I-ORG Project I-ORG 2015GB121004 O from O Ministry O of O Science O and O Technology O of O China O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 11375018 B-AWARD 11528508 B-AWARD 51231008 B-AWARD 51320105014 B-AWARD 51321003 B-AWARD 51501225 B-AWARD 61377056 B-AWARD and O China B-ORG University I-ORG of I-ORG Petroleum I-ORG Beijing I-ORG grant O number O 2462015YQ0602 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32130092 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province I-ORG 2020-MS-205 O Liaoning B-ORG Key I-ORG R&D I-ORG Program I-ORG 2020JH2/10200032 O and O Shenyang B-ORG Young I-ORG and I-ORG Middle-aged I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Talents I-ORG Support I-ORG Plan I-ORG RC220306 O This O research O was O funded O by O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2011YQ030114 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81421004 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Beijing I-ORG Municipality I-ORG 7162113 O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81400019 O to O Jinhong O Wu O the B-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG Pudong I-ORG New I-ORG Area I-ORG No. O PKJ2013-Y65 B-AWARD to O Jinhong O Wu) O and O the B-ORG Shanghai I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG Biomedicine I-ORG Department I-ORG key I-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG 16411950800 O to O Hao O Zhang O This O work O is O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31871341 O 31601064 B-AWARD the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Proteomics I-ORG SKLP-K201702 O the O Innovation B-ORG Project I-ORG 16CXZ027 O the O Beijing B-ORG Nova I-ORG Program I-ORG Z171100001117117 O and O the O Program B-ORG of I-ORG Precision I-ORG Medicine I-ORG 2016YFC0901905 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O General B-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81373161 B-AWARD General B-ORG Program I-ORG of I-ORG Medical I-ORG and I-ORG Health I-ORG Research I-ORG of I-ORG Zhejiang I-ORG Province I-ORG grant O number O 2012KYA081 O 2013KYB095 B-AWARD Research B-ORG Program I-ORG of I-ORG Public I-ORG Welfare I-ORG Technology I-ORG Experimental I-ORG Animals I-ORG of I-ORG Zhejiang I-ORG Province I-ORG grant O number O 2016C37124 B-AWARD and O General O Research O Program O of O Education O Department O Zhejiang O Province O grant O number O Y201017002 O This O study O was O supported O by O a O grant O from O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20150112 O Grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81302542 O 81202474 B-AWARD 81273464 B-AWARD and O 81473146 B-AWARD Changzhou B-ORG Special I-ORG Project I-ORG of I-ORG Biotechnology I-ORG and I-ORG Biopharmacy I-ORG No. O CE20105006 B-AWARD Science O Bridges O China-Changzhou O Biotechnology O and O Pharmaceutical O Technology O Special O Project O Grant O Number O CE20105006 O The O School B-ORG of I-ORG Medicine I-ORG Foundation O grant O number O 3712910 B-AWARD the O Health B-ORG Research I-ORG Council I-ORG of I-ORG New I-ORG Zealand I-ORG grant O number O 12/1111 B-AWARD and O a O grant-in-aid O from O the O Maurice B-ORG and I-ORG Phyllis I-ORG Paykel I-ORG Trust O grant O number O 3711140 B-AWARD This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2017YFC1103800 B-AWARD the B-ORG International I-ORG Partnership I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Grant O No. O GJHZ2044 B-AWARD and O Interiplinary B-ORG Research I-ORG Founding I-ORG of I-ORG 9th I-ORG People’s I-ORG Hospital I-ORG affiliated I-ORG to I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG School I-ORG of I-ORG Medicine I-ORG Grant O No. O JYJC201913 B-AWARD This O research O was O supported O by O the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 863 O Program O 2011AA020101 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG SQ2017YFSF090065 O and O the O General O Program O of O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81471052 O This O work O is O supported O by O the B-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG CAAS-ASTIP-2018-ZFRI O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31701880 O and O the B-ORG Central I-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG 1610192017703 O The O funding O body O had O no O role O in O the O design O of O the O study O the O interpretation O of O data O and O the O writing O of O the O manuscript O This O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81660297 B-AWARD the O Research B-ORG Program I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG at I-ORG Universities I-ORG of I-ORG Inner I-ORG Mongolia I-ORG Autonomous I-ORG Region I-ORG No. O NJZY069 B-AWARD The B-ORG Innovation I-ORG Fund I-ORG for I-ORG Young I-ORG Talent I-ORG at I-ORG College I-ORG of I-ORG Veterinary I-ORG Medicine I-ORG Inner I-ORG Mongolia I-ORG Agricultural I-ORG University I-ORG No. O 2015QNJJ01 B-AWARD This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG for I-ORG Crop I-ORG Breeding I-ORG 2016YFD0102105 O the O Science B-ORG and I-ORG Technology I-ORG Program I-ORG for I-ORG Innovation I-ORG Talents I-ORG of I-ORG Harbin I-ORG 2014RFQYJ016 O 2014RFXYJ011 B-AWARD and O the O Project B-ORG of I-ORG the I-ORG Heilongjiang I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG HAAS O 2017BZ12 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41725020 O 41922038 B-AWARD 41625020 B-AWARD 91744311 O and O 41921005 O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG the I-ORG People's I-ORG Republic I-ORG of I-ORG China I-ORG 2016YFC0200500 O the O Jiangsu B-ORG Provincial I-ORG Fund I-ORG on O PM2.5and O O3pollution O mitigation O and O the O Jiangsu O provincial O innovation O center O for O climate O change O This O research O was O financially O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81741167 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O China O 2018A030310151 O Research O and O Development O Start-up O Foundation O NTF16014 O and O Cultivation O Fund O NTF17001 O of O Shantou O University O Department B-ORG of I-ORG Education I-ORG of I-ORG Guangdong I-ORG Province O China O 2017KQNCX077 O This O work O was O supported O by O Key B-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG in I-ORG Shaanxi I-ORG Province I-ORG Grant O No. O 2018ZDXM-NY-064 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31472167 B-AWARD 31972645 O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Yangling I-ORG demonstration I-ORG zone I-ORG Grant O No. O 2018NY-35 B-AWARD and O Central B-ORG Project I-ORG of I-ORG Major I-ORG Agricultural I-ORG Technology I-ORG Promotion I-ORG Funds I-ORG Grant O No. O K3360217060 B-AWARD This O study O was O sponsored O in O part O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG #81572332 O and O 81572358 O Shanghai B-ORG Pujiang I-ORG Program I-ORG 2019PJD052 O and O Science B-ORG I-ORG Technology I-ORG Support I-ORG Program I-ORG Medicine I-ORG Guidance I-ORG of I-ORG Shanghai I-ORG S&T I-ORG Committee I-ORG 124119A4400 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O 32102452 O Joint B-ORG Foundation I-ORG of I-ORG Basic I-ORG Applied I-ORG Basic I-ORG Research I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2020A1515110100 O Special B-ORG Fund I-ORG for I-ORG Scientific I-ORG Innovation I-ORG Strategy-Construction I-ORG of I-ORG High-Level I-ORG Academy I-ORG of I-ORG Agriculture I-ORG Science I-ORG R2021YJ-YB-3024 O R2019YJ-YB3011 B-AWARD and O Guangdong B-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Quality I-ORG I-ORG Safety I-ORG Risk I-ORG Assessment I-ORG for I-ORG Agro-products I-ORG 2019B121203009 O This O study O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG NO. O 2022A1515010576 B-AWARD and O the O Project B-ORG of I-ORG Guangdong I-ORG International I-ORG Hong I-ORG Kong I-ORG Macao I-ORG and I-ORG Taiwan I-ORG high-end I-ORG talent I-ORG exchange I-ORG program I-ORG NO. O K21425 B-AWARD and O the O Program B-ORG for I-ORG Scientific I-ORG Research I-ORG Start-Fund I-ORG of I-ORG Guangdong I-ORG Ocean I-ORG University I-ORG NO. O R20063 B-AWARD National B-ORG College I-ORG Students’ I-ORG innovation I-ORG and I-ORG entrepreneurship I-ORG training I-ORG program I-ORG NO. O 010403052115 B-AWARD This O research O was O funded O by O Wenzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Association I-ORG Service I-ORG Technology I-ORG Innovation I-ORG Project O grant O number O kjfw12 B-AWARD Scientific B-ORG Research I-ORG Fund I-ORG of I-ORG Zhejiang I-ORG Provincial I-ORG Education I-ORG Department I-ORG Project O No. O Y202146845 B-AWARD and O Wenzhou B-ORG Public I-ORG Welfare I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project O No. O G20210018 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31771402 O 31970590 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC1604000 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2662017PY116 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O jointly O supported O by O the O “National O Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China” O 2018YFD0502203 O “Special O Fund I-ORG for I-ORG the I-ORG Henan I-ORG Agriculture I-ORG Research I-ORG System” O HARS-22-13-G1 O and O “Special O Fund I-ORG for I-ORG the I-ORG Construction I-ORG of I-ORG National I-ORG Modern I-ORG Agricultural I-ORG Industrial I-ORG Park I-ORG of I-ORG Biyang I-ORG County” O NMAIP-BY-S01 O This O work O was O supported O by O the O research O grant O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31670361 O Key B-ORG Technology I-ORG R.D I-ORG Programme I-ORG of I-ORG Qinghai I-ORG Province I-ORG 2016-SF-126 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Provincial I-ORG Education I-ORG Department I-ORG KJ2013A027 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Province I-ORG 1708085MH198 O This O work O was O supported O by O grants O from O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 81701856 B-AWARD and O 31570939 B-AWARD the B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shaanxi I-ORG Program O No. O 2018SF-039 B-AWARD and O Young B-ORG Talent I-ORG fund I-ORG of I-ORG University I-ORG Association I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG in I-ORG Shaanxi I-ORG China I-ORG Grant O No.20170402 O This O research O was O supported O by O unrestricted O grants O from O Sanofi-Aventis B-ORG Germany O NNBC-3 B-AWARD 31/10/2002 O FP4 B-ORG BIOMED I-ORG 2 I-ORG BMH4 B-AWARD 98-3418 O Martin B-ORG Luther I-ORG University I-ORG Halle-Wittenberg I-ORG NBL I-ORG Program I-ORG FKZ B-AWARD 15/29 I-AWARD and O 17/37 B-AWARD and O AGO-B B-ORG Breast I-ORG Study I-ORG Group I-ORG AGOB001 B-AWARD This O work O was O supported O by O the O US O National B-ORG Institutes I-ORG of I-ORG Health I-ORG R01 B-AWARD CA102667 I-AWARD RR O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG Australia O Grant O 1082022 B-AWARD and O Australian B-ORG Research I-ORG Council I-ORG Grant O 180103873 B-AWARD MPD O is O a O National O Health O and O Medical O Research O Council O Australia O Senior O Research O Fellow O APP1080001 O Agence B-ORG Nationale I-ORG de I-ORG la I-ORG Recherche I-ORG Grant/Award O Number O ANR‐10‐EQPX‐16 B-AWARD Xyloforest O Université B-ORG de I-ORG Liège I-ORG Grant/Award O Number O ‘Special O Research I-AWARD Fund I-AWARD 2014 O and O European O Community's O Seventh B-ORG Framework I-ORG Programme I-ORG EU O FP7 O Grant/Award O Number O Trees4Future B-AWARD 284181 O This O work O was O supported O by O the O grant O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81370941 B-AWARD Gang O Yuan O Graduates’ B-ORG Innovation I-ORG Fund I-ORG Huazhong I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG No. O 5003540003 B-AWARD Huihui O Ren O and O Thyroid B-ORG Research I-ORG Program I-ORG of I-ORG Young I-ORG and I-ORG Middle-aged I-ORG Physicians I-ORG No.2016-N-07 O Zhelong O Liu O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O the O earmarked O fund O for O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-30 O and O grants O from O Jiangsu B-ORG Agriculture I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Fund I-ORG CX O 15)1020 O Six B-ORG Talent I-ORG Fund I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O NY068 B-AWARD and O the O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51978232 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Tianjin I-ORG City I-ORG China I-ORG No. O 19JCJQJC63000 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG China I-ORG No. O E2019202012 B-AWARD and O the O Key-Area B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG No. O 2022B0101090004 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51903201 O 81903662 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG xzy012019077 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O 2019M653660 O the B-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG Programs I-ORG of I-ORG Higher I-ORG Education I-ORG Institutions I-ORG in I-ORG Shanxi I-ORG 2019L0428 O the B-ORG Startup I-ORG Foundation I-ORG for I-ORG Doctors I-ORG of I-ORG Shanxi I-ORG Province I-ORG SD1827 O and O the B-ORG Startup I-ORG Foundation I-ORG for I-ORG Doctors I-ORG of I-ORG Shanxi I-ORG Medical I-ORG University I-ORG XD1824 O This O study O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0900803 O Ph.D B-ORG Research I-ORG Program I-ORG of I-ORG Xinxiang I-ORG Medical I-ORG University I-ORG 505323 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U1604178 O English O language O polishing O and O publishing O costs O of O this O manuscript O were O paid O by O the O funding O from O 2016YFC0900803 O 505323 O and O U1604178 O This O work O was O financially O supported O by O grants O from O the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0101500 O 2016YFD0101504 O the B-ORG National I-ORG Hightech I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2011AA10A105 O and O the B-ORG Program I-ORG for I-ORG Changjiang I-ORG Scholars I-ORG and I-ORG Innovative I-ORG Research I-ORG Team I-ORG in I-ORG University I-ORG PCSIRT_17R55 O PCSIRT13073 O This O study O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O nos O 51576035 B-AWARD and O 51604078 B-AWARD and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG grant O no. O N162504012 B-AWARD and O Post-Doctoral B-ORG Science I-ORG Foundation I-ORG grant O nos O 2017M610185 B-AWARD and O 20170101 B-AWARD This O work O was O supported O by O grants O from O the O Chang B-ORG Gung I-ORG Memorial I-ORG Hospital I-ORG research O grant O CMRPG8E1441 B-AWARD and O CMRPG8K0761 B-AWARD and O the O Taiwan B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG MOST O 108-2628-B-182-001 I-AWARD and O MOST B-AWARD 109-2314-B-182-045-MY2 O The O authors O thank O the O “Molecular O Medicine O Research O Center O Chang B-ORG Gung I-ORG University” O from O The O Featured O Areas O Research O Center O Program O within O the O framework O of O the O Higher O Education O Sprout O Project O by O the O Ministry B-ORG of I-ORG Education I-ORG MOE I-ORG in I-ORG Taiwan I-ORG EMRPD1M0281 O We O also O acknowledge O the O Genomics O and O Proteomics O Core O Laboratory O Department O of O Medical O Research O Kaohsiung O Chang O Gung O Memorial O Hospital O and O Next O Generation O Sequencing O Core O and O Bioinformatics O core O grant O CLRPD1J0013 B-AWARD at O Chang O Gung O University O Taoyuan O Taiwan O for O technical O support O This O research O was O funded O by O the O financial O support O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81703494 O Science B-ORG Foundation I-ORG of I-ORG the I-ORG Educational I-ORG Department I-ORG of I-ORG Liaoning I-ORG Province I-ORG LJKZ0914 O Career B-ORG Development I-ORG Program I-ORG for I-ORG Young I-ORG Teachers I-ORG of I-ORG Shenyang I-ORG Pharmaceutical I-ORG University I-ORG ZQN2021004 O This O work O was O supported O by O NOAA B-ORG EESLR O NA15NOS4780172 O NSF-GLD B-ORG EAR-1324973 O and O the O Virginia B-ORG Coast I-ORG Reserve I-ORG Long-Term I-ORG Ecological I-ORG Research I-ORG Program I-ORG NSF O DEB-123773 O Support O for O Elsemarie O Mullins O was O also O provided O by O the O NSF B-ORG GRFP I-ORG DGE-1650116 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31572446 B-AWARD the O National B-ORG High-Tech I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 863 O Program O No. O 2013AA102803 B-AWARD the O National B-ORG Chicken I-ORG Industry I-ORG Technology I-ORG System I-ORG of I-ORG China I-ORG No. O CARS-42 B-AWARD and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFD0501409 B-AWARD This O work O was O supported O by O the O grants O from O the O Strategic O Priority O Research O Programme O of O the O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG XDA24020000 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0101801 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31771360 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O Grant O 21676120 B-AWARD 31872891 B-AWARD the O 111 O Project O Grant O 111-2-06 O the O High-end B-ORG Foreign I-ORG Experts I-ORG Recruitment I-ORG Program I-ORG Grant O G20190010083 B-AWARD the O Program B-ORG for I-ORG Advanced I-ORG Talents I-ORG within I-ORG Six I-ORG Industries I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grant O 2015-NY-007 B-AWARD the O National O Program O for O Support O of O Top-notch O Young O Professionals O the O Fundamental O Research O Funds O for O the O Central O Universities O Grant O JUSRP51504 O the O Project O Funded O by O the O Priority O Academic O Program O Development O of O Jiangsu O Higher O Education O Institutions O Top-notch O Academic O Programs O Project O of O Jiangsu O Higher O Education O Institutions O the O Jiangsu O Province O “Collaborative O Innovation O Center O for O Advanced O Industrial O Fermentation” O Industry O Development O Program O the O Program O for O the O Key O Laboratory O of O Enzymes O of O Suqian O M201803 O and O the O National B-ORG First-Class I-ORG Discipline I-ORG Program I-ORG of I-ORG Light I-ORG Industry I-ORG Technology I-ORG and I-ORG Engineering I-ORG Grant O LITE2018-09 B-AWARD This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81472441 B-AWARD 31271272 B-AWARD six B-ORG major I-ORG talent I-ORG summit I-ORG No. O 2013-wsn-62 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O BK20131439 B-AWARD This O work O is O supported O by O grants O from O Zhejiang B-ORG Research I-ORG Center I-ORG for I-ORG lung I-ORG cancer I-ORG diagnosis I-ORG and I-ORG treatment I-ORG technology I-ORG JBZX-202007 O Key B-ORG disciplines I-ORG of I-ORG traditional I-ORG Chinese I-ORG medicine I-ORG integration I-ORG of I-ORG Chinese I-ORG and I-ORG Western I-ORG Medicine I-ORG in I-ORG Zhejiang I-ORG Province I-ORG 2017-XK-A33 O the B-ORG National I-ORG key I-ORG research I-ORG and I-ORG development I-ORG plan I-ORG 2017YFC0113500 O Major B-ORG science I-ORG and I-ORG technology I-ORG special I-ORG project I-ORG of I-ORG Zhejiang I-ORG province I-ORG 2014C03032 O This O work O was O supported O by O the O Natural B-ORG Sciences I-ORG and I-ORG Engineering I-ORG Research I-ORG Council I-ORG of I-ORG Canada I-ORG RGPIN-2015-03948 O to O M.M.H O the O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG 384410 O to O R.C.W.C O and O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG U41HG007000 O to O W.S.N O This O project O was O supported O financially O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81573268 O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG 18431900600 O and O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG China I-ORG 2018ZX09711002-002-016 O This O work O was O supported O by O a O US-Israel B-ORG Binational I-ORG Agricultural I-ORG and I-ORG Development I-ORG Fund I-ORG BARD O US-4571-12C B-AWARD grant O to O MLT O Shimon O Meir O and O Sonia O Philosoph-Hadas O the O United B-ORG States I-ORG Department I-ORG of I-ORG Agriculture I-ORG USDA O Project O 1245-21220-232-00D B-AWARD and O by O the O National O Research O Foundation O of O Korea O NRF O grant O funded O by O the O Korean O government O Ministry O of I-ORG Science I-ORG ICT I-ORG I-ORG Future I-ORG Planning O NRF-2017R1A2B4010356 O to O JK. O The O authors O acknowledge O the O financial O support O for O this O study O from O the O Special B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG 2016YFD0400206 O Postgraduate B-ORG Research I-ORG Practice I-ORG Innovation I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG KYCX17-1225 O and O a O project O funded O by O the O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 22169009 B-AWARD the O Jiangxi B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG no. O 20212ACB204007 B-AWARD and O the O Jiangxi B-ORG Key I-ORG Laboratory I-ORG of I-ORG Functional I-ORG Molecular I-ORG Materials I-ORG Chemistry I-ORG no. O 205200100543 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51890884 B-AWARD No. O 62103324 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O xpt012022009 B-AWARD and O the O Open B-ORG Research I-ORG Projects I-ORG of I-ORG Zhejiang I-ORG Lab I-ORG No. O 2019MB0AB02 B-AWARD This O research O was O funded O by O the O Thailand B-ORG Research I-ORG Fund I-ORG RSA5880019 O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Agency I-ORG RES5829130016 O and O the O National B-ORG Research I-ORG University I-ORG Project I-ORG Office I-ORG of I-ORG Higher I-ORG Education I-ORG Commission I-ORG NRU59-056-AS O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O We O are O thankful O to O the O WWF/USAID/Hariyo B-ORG Ban I-ORG Program I-ORG WU82 O Red B-ORG Panda I-ORG Network I-ORG Ref-13/2014 O and O Idea B-ORG Wild I-ORG 30July O 2015 O for O financially O supporting O this O work O These O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 3226180451 O the O Guizhou B-ORG Province I-ORG Outstanding I-ORG Young I-ORG Scientific I-ORG and I-ORG Technological I-ORG Talent I-ORG Cultivation I-ORG Project I-ORG Qiankehe O Platform O Talent O 2019 O 5651 B-AWARD and O the O Guizhou B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG Qiankehe O Support O 2021 O General O 111 B-AWARD This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31900344 O Project B-ORG of I-ORG Biodiversity I-ORG Survey I-ORG and I-ORG Assessment I-ORG in I-ORG Guiyang I-ORG GZZC-2021-018 O and O Youth B-ORG Innovation I-ORG Team I-ORG Development I-ORG Project I-ORG of I-ORG Shandong I-ORG Universities I-ORG 2019KJE018 O This O work O is O funded O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O the O Grant O No. O 51875225 B-AWARD and I-AWARD 51605095 O in O part O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG under O the O Grant O No. O 2018YFB1702302 B-AWARD and O in O part O by O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG under O the O Grant O No. O 2019B090916001 B-AWARD This O research O was O funded O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China O grant O number O 2016YFC1302100 B-AWARD the B-ORG CAMS I-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences O grant O number O 2016-I2M-1-001 B-AWARD and I-AWARD 2019-I2M-1-003 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Inner I-ORG Mongolia I-ORG Autonomous I-ORG Region O grant O number O 2019MS08078 B-AWARD Funding O provided O by O National B-ORG Natural I-ORG Science I-ORG Funds I-ORG No.31272431):https://isisn.nsfc.gov.cn/egrantweb O This O funder O had O a O role O in O study O design O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 863 I-ORG Program I-ORG No.2011AA100305):http://program.most.gov.cn O This O funder O had O a O role O in O data O collection O and O analysis O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG No.CARS-42):http://119.253.58.231 O This O funder O had O a O role O in O study O design O data O collection O and O analysis O This O funder O had O a O role O in O decision O to O publish O Jilin B-ORG Provincial I-ORG Agriculture I-ORG Research I-ORG System I-ORG and I-ORG the I-ORG Key I-ORG Project I-ORG of I-ORG Education I-ORG Department I-ORG of I-ORG Jilin I-ORG Province I-ORG No.2013-47):http://www.jlxm.gov.cn O This O funder O had O a O role O in O preparation O of O the O manuscript O Jilin O Grain O Group O Agriculture O and O Livestock O Co O Ltd O provided O support O in O the O form O of O salaries O for O authors O SGY O but O did O not O have O any O additional O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O specific O roles O of O these O authors O are O articulated O in O the O “author O contributions” O section O This O research O was O funded O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O 51609066 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O 2018B14714 B-AWARD and O 2018B43614 B-AWARD and O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O 2018M630507 B-AWARD and O 2019T120389 B-AWARD This O study O is O funded O by O the O grants O of O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81771825 O Beijing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG D17110003017003 O and O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2017YFC1307904 O The O study O was O supported O by O grants O from O the O Natural O Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG of I-ORG China I-ORG 2018A030313771 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO.81700263 O and O the B-ORG Science I-ORG and I-ORG Technology I-ORG project I-ORG of I-ORG Shenzhen I-ORG city I-ORG of I-ORG China I-ORG JCYJ20160426100250466 O and O JCYJ20170306152620264 B-AWARD This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO.81473518 O and O No.81573824 O Beijing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG No.Z141107002515019 O and O the O Capital B-ORG Health I-ORG Research I-ORG and I-ORG Development I-ORG of I-ORG Special I-ORG No.SF2014-1-4191 O This O study O was O supported O by O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province O China O 2015B020226002 O 2017A020215012 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81870511 O 82170770 B-AWARD 31800758 B-AWARD Key B-ORG Scientific I-ORG and I-ORG Technological I-ORG Program I-ORG of I-ORG Guangzhou I-ORG City I-ORG 201803040011 O 201903010058 B-AWARD Guangdong B-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG on I-ORG Organ I-ORG Donation I-ORG and I-ORG Transplant I-ORG Immunology I-ORG 2017B030314018 O 2020B1212060026 B-AWARD and O Guangdong B-ORG Provincial I-ORG International I-ORG Cooperation I-ORG Base I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Organ O Transplantation O 2020A0505020003 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31972380 O the O Key B-ORG Project I-ORG of I-ORG the I-ORG Department I-ORG of I-ORG Science I-ORG I-ORG Technology I-ORG of I-ORG Liaoning I-ORG Provence I-ORG 2020-MS-349 O and O the O project B-ORG of I-ORG the I-ORG education I-ORG department I-ORG of I-ORG Liaoning I-ORG Province I-ORG LJKZ0647 O This O work O was O funded O by O the O 948 B-ORG project I-ORG of I-ORG the I-ORG Agricultural I-ORG Department I-ORG of I-ORG China I-ORG 2013-Z70 O National B-ORG bast I-ORG fiber I-ORG germplasm I-ORG resources I-ORG project I-ORG of I-ORG China I-ORG K47NI201A O and O National B-ORG bast I-ORG fiber I-ORG research I-ORG system I-ORG of I-ORG China I-ORG CARS-19-E06 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2019YFC1804103 O the O Shandong B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2019JZZY020328 O and O the O Cultivate B-ORG Excellence I-ORG Foundation I-ORG of I-ORG Qilu I-ORG University I-ORG of I-ORG Technology I-ORG 2022PY035 O This O research O was O funded O by O the O Research B-ORG Foundation I-ORG of I-ORG Education I-ORG Department I-ORG of I-ORG Zhejiang I-ORG No. O Y202147210 B-AWARD the O Xinmiao B-ORG Talent I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. O 2022R426A017 B-AWARD and O Scientific B-ORG Innovation I-ORG Teams I-ORG in I-ORG Tourism I-ORG College I-ORG of I-ORG Zhejiang I-ORG No. O 2022TDDS07 B-AWARD This O research O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2018YFD1000200 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31722042 O 31901737 B-AWARD and O the O Fok B-ORG Ying I-ORG Tung I-ORG Education I-ORG Foundation O China O 161028 O The O funders O had O no O role O in O the O material O creation O designing O the O study O analysis O data O and O in O writing O the O manuscript O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31971843 O the O Technology B-ORG System I-ORG of I-ORG Modern I-ORG Agricultural I-ORG Industry I-ORG in I-ORG Guangdong I-ORG 2017 O LM1098 O and O the O World B-ORG Bank I-ORG Loan I-ORG Agricultural I-ORG Pollution I-ORG Control I-ORG Project I-ORG in I-ORG Guangdong I-ORG 0724-1510A08N3684 O This O work O was O supported O by O the O following O grants O U.S B-ORG Department I-ORG of I-ORG Defense I-ORG DAMD17-01-1-0447 B-AWARD PI: O Dr. O Nancy O E. O Avis O National B-ORG Science I-ORG Foundation I-ORG SES-1424875 B-AWARD PI: O Dr. O Edward O H. O Ip O and O National B-ORG Institutes I-ORG of I-ORG Health I-ORG UL1 B-AWARD TR001420 I-AWARD and O P30 O CA012197 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O used O data O from O the O Japan O Gerontological O Evaluation O Study O JAGES O which O was O funded O by O JSPS O Japan O Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science O KAKENHI O Grant O Number O JP15H01972 O 16H03276 B-AWARD 19K14029 B-AWARD and O 20H00557 B-AWARD a O Health O Labour O Sciences O Research O Grant O H28-Choju-Ippan-002 O H30-Junkanki-Ippan-004 B-AWARD 19FA1012 B-AWARD and O 19FA2001 B-AWARD grants O from O the O Japan B-ORG Agency I-ORG for I-ORG Medical I-ORG Research I-ORG and I-ORG Development I-ORG JP18dk0110027 O JP18ls0110002 B-AWARD JP18le0110009 B-AWARD JP19dk0110034 B-AWARD and O JP20dk0110034 B-AWARD Research O Funding O for O Longevity O Sciences O from O the O National B-ORG Center I-ORG for I-ORG Geriatrics I-ORG and I-ORG Gerontology I-ORG 29–42 O and O a O JST-OPERA B-ORG program I-ORG grant I-ORG JPMJOP1831 O This O study O was O also O supported O by O JSPS B-ORG KAKENHI I-ORG Grant O Number O 22K10578 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O No. O 52001045 B-AWARD and O No. O 51779025 B-AWARD Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Foundation I-ORG of I-ORG Dalian I-ORG China O grant O number O No. O 2021JJ11CG004 B-AWARD Laboratory B-ORG of I-ORG Transport I-ORG Pollution I-ORG Control I-ORG and I-ORG Monitoring I-ORG Technology O grant O number O No. O Z2209-030 B-AWARD The O APC O was O funded O by O the O Science O and O Technology O Innovation O Foundation O of O Dalian O China O grant O number O No. O 2021JJ11CG004 O This O research O was O funded O by O the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0900103 O 2022YFF1000304 B-AWARD the O National B-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG of I-ORG China I-ORG 31972782 O and O 32273102 B-AWARD and O the B-ORG Strategic I-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Grant O No. O XDA24030105 B-AWARD This O work O was O funded O by O an O ARC B-ORG Discovery I-ORG Project I-ORG grant O DP130102066 O awarded O to O PT O and O AP O and O a O Queensland B-ORG Government I-ORG Department I-ORG of I-ORG Environment I-ORG and I-ORG Heritage I-ORG Protection I-ORG Koala I-ORG Research I-ORG Grant I-ORG KRG18 O awarded O to O AP O and O PT. O NRT O is O supported O by O a O Wellcome B-ORG Trust I-ORG grant I-ORG 098051 B-AWARD from O the O Wellcome O Trust O Sanger O Institute O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61540073 O Guangxi B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No.2016GXNSFAA380053 O Guangxi B-ORG Innovation-Driven I-ORG Development I-ORG Project I-ORG AA18118001 O Guangxi O Key O Laboratory O of O Information O Materials O Foundation O No. O 161014-Z O The O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Xinjiang I-ORG Uygur I-ORG Autonomous I-ORG Region I-ORG No. O 2021D01C034 B-AWARD Autonomous B-ORG Region I-ORG Key I-ORG R&D I-ORG Projects I-ORG No. O 2022B01045 B-AWARD and O 2022B01001 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 21666036 B-AWARD and O 11764040 B-AWARD Tianshan B-ORG Innovation I-ORG Team I-ORG Program I-ORG of I-ORG Xinjiang I-ORG Uygur I-ORG Autonomous I-ORG Region I-ORG No. O 2020D14038 B-AWARD Financial O support O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 11705137 B-AWARD NSAF B-ORG Joint I-ORG Fund I-ORG No. O U1830124 B-AWARD and O Project O Funded O by O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2018T111053 B-AWARD 2015M582669 B-AWARD is O acknowledged O This O work O is O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31670040 O 31470162 B-AWARD and O 31770047 B-AWARD National B-ORG Key I-ORG Technology I-ORG Support I-ORG Program I-ORG 2015BAD15B05 O Key B-ORG Research I-ORG and I-ORG Development I-ORG Support I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG 2016GGH3103 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017M622186 O Fundamental B-ORG Research I-ORG Funds I-ORG of I-ORG Shandong I-ORG University I-ORG 2017TB0010 O and O Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG ZR2017MC071 O This O study O was O partly O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41991314 O 81530086 B-AWARD 81803246 B-AWARD Shanghai B-ORG Municipal I-ORG Health I-ORG Commission I-ORG GWIII-26 O 20174Y0133 B-AWARD 201640032 B-AWARD and O the O Shanghai O Jiao O Tong O University O School O of O Medicine O and O supported O by O the B-ORG National I-ORG Human I-ORG Genetic I-ORG Resources I-ORG Sharing I-ORG Service I-ORG Platform I-ORG 2005DKA21300 O and O Xinhua O Hospital O Biobank O This O work O was O supported O by O grants O from O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0101000 O Technology B-ORG Innovation I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG of I-ORG Shanxi I-ORG province I-ORG 2017142 O and O Science B-ORG I-ORG Technology I-ORG Innovation I-ORG Foundation I-ORG of I-ORG Shanxi I-ORG Agricultural I-ORG University I-ORG 2016YJ05 O The O CHIRI O study O funded O by O the O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG NHMRC O of O Australia O under O the O Global O Alliance O for O Chronic O Disease O 42] O call O for O hypertension O management O 43 O RJ O is O funded O by O a O Future O Leader O Fellowship O funded O by O the O Australian B-ORG National I-ORG Heart I-ORG Foundation I-ORG GNT100484 O AGT O was O funded O by O a O Fellowship O provided O by O the O NHMRC O GNT1042600 O PKM O is O a O Wellcome O Trust/DBT O India I-ORG Alliance I-ORG Intermediate O Career O Fellow O IA/I/13/1/500879 O The O funding O agencies O had O no O role O in O the O design O or O conduct O of O the O study O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82274647 O UTHSC/WCHSU B-ORG CORNET I-ORG Award I-ORG YB2019003 O and O Special O fund O for O CRISPR/Cas9 B-ORG gene I-ORG editing I-ORG technology I-ORG of I-ORG the I-ORG Regenerative I-ORG Medicine I-ORG Research I-ORG Center I-ORG of I-ORG West I-ORG China I-ORG Hospital I-ORG 161170012 O This O research O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81560046 B-AWARD Guangxi B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 2016GXNSFAA380002 B-AWARD Scientific B-ORG Project I-ORG of I-ORG Guangxi I-ORG Higher I-ORG Education I-ORG No. O KY2015ZD028 B-AWARD Science B-ORG Research I-ORG and I-ORG Technology I-ORG Development I-ORG Project I-ORG of I-ORG Qingxiu I-ORG District I-ORG of I-ORG Nanning I-ORG No. O 2016058 B-AWARD and O Lisheng B-ORG Health I-ORG Foundation I-ORG pilotage I-ORG fund I-ORG of I-ORG Peking I-ORG No. O LHJJ20158126 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 31201586 B-AWARD Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangdong O China O grant O no. O 2014A020208138 B-AWARD and O 2015A020208018 B-AWARD Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Zhanjiang I-ORG City O China O grant O no.2016A03016 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Lingnan I-ORG Normal I-ORG University I-ORG grant O no. O LZL1507 B-AWARD All O these O funding O play O roles O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O study O was O supported O in O part O by O the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 863 O Program O 2015AA020311 O NSFC B-ORG grants I-ORG 31600971 B-AWARD 81300799 I-AWARD 81320108010 I-AWARD 81170876 I-AWARD 31271029 I-AWARD 81570883 O Shanghai B-ORG Municipality I-ORG Commission I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG 14JC1493103 O 12419A9300 O Shanghai B-ORG Municipal I-ORG Education I-ORG Commission-Gaofeng I-ORG Clinical I-ORG Medicine I-ORG Grant I-ORG Support I-ORG 20152228 O Shanghai B-ORG Municipal I-ORG Hospital I-ORG Emerging I-ORG Frontier I-ORG Technology I-ORG Joint I-ORG Research I-ORG Project I-ORG SHDC12012107 O and O Shanghai B-ORG JiaoTong I-ORG University I-ORG Medical I-ORG I-ORG Engineering I-ORG Cross I-ORG Fund I-ORG YG2014MS03 O This O research O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51705029 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG CHD I-ORG 300102250203 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 2020JQ-375 O and O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2019M653515 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 41801381 B-AWARD the O Jiangsu B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O No. O BK20170379 B-AWARD and O the O Hubei B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2017CFB654 B-AWARD This O research O was O funded O by O the O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG CAPES O Scholarship O number O 88887.500342/2020-00 B-AWARD Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq O Process O number O 303511/2019-2 B-AWARD and O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG de I-ORG Minas I-ORG Gerais I-ORG FAPEMIG O Edital O 01-2017 O APQ-00539-17 B-AWARD We O would O like O to O thank O the O Key O Scientific O Research O Projects O of O Higher B-ORG Education I-ORG of I-ORG Henan I-ORG Province I-ORG 22A210014 O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2020YJ0406 O and O the O Science B-ORG and I-ORG Technology I-ORG Development I-ORG Project I-ORG of I-ORG Henan I-ORG Province I-ORG 212102110054 O 222102110146 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 31801732 B-AWARD 31701786 B-AWARD and O 31171842 B-AWARD the O National B-ORG Key I-ORG Research I-ORG Program I-ORG grant O number O 2018YFD0300804 B-AWARD the O Key B-ORG Research I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG grant O number O BE2018355 B-AWARD and O the O Jiangsu O Agricultural O Scientific O Self-innovation O Fund O grant O number O CX[18]1003 O This O research O was O supported O by O the O Basic O Science O Research O Program O through O the O National O Research O Foundation O NRF O funded O by O the O Ministry B-ORG of I-ORG Science I-ORG ICT I-ORG and I-ORG Future I-ORG Planning I-ORG 2016R1C1B2006534 O and O Creative O Materials O Discovery O Program O through O the O National O Research O Foundation O of O Korea O NRF O funded O by O Ministry B-ORG of I-ORG Science I-ORG and I-ORG ICT I-ORG NRF-2018M3D1A1059001 O This O research O was O also O supported O by O Korea B-ORG Electric I-ORG Power I-ORG Corporation I-ORG R18XA06-02 O Jiangsu B-ORG Provincial I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Special I-ORG Fund I-ORG BE2015666 O Jiangsu B-ORG Innovative I-ORG team I-ORG leading I-ORG talent I-ORG fund I-ORG CXTDC2016006 O Jiangsu B-ORG Natural I-ORG Science I-ORG Foundation I-ORG BK20171304 O Jiangsu B-ORG six I-ORG high I-ORG peak I-ORG talent I-ORG fund I-ORG WSW-205 O and O Jiangsu B-ORG 333 I-ORG talent I-ORG fund I-ORG BRA2016140 O This O research O was O funded O by O Cancer B-ORG Research I-ORG UK I-ORG C44767/A29458 O and O C23017/A27935 B-AWARD and O EPSRC B-ORG EP/W007096/1 O C.W O was O supported O by O an O MRC B-ORG Skills I-ORG Development I-ORG fellowship I-ORG MR/S007687/1 O This O work O was O supported O by O grants O from O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Programme I-ORG of I-ORG China I-ORG 2018YFA0208902 O 2020YFC2002705 O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O No.U1604281 I-AWARD 81672138 O Beijing B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG BJSFC O No. I-AWARD 7171008 O National B-ORG Key I-ORG Scientific I-ORG Instrument I-ORG Special I-ORG Programme I-ORG of I-ORG China I-ORG Grant O No. O 2011YQ03013405 B-AWARD This O study O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81602054 O and O the O Applied B-ORG Basic I-ORG Research I-ORG of I-ORG Changzhou I-ORG Technology I-ORG Bureau I-ORG CJ20190093 O Major B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Changzhou I-ORG Health I-ORG Commission I-ORG ZD201906 O The B-ORG “Six I-ORG One I-ORG Project” I-ORG top-notch I-ORG talent I-ORG research I-ORG project I-ORG of I-ORG high-level I-ORG health I-ORG talents I-ORG of I-ORG Jiangsu I-ORG Provincial I-ORG Health I-ORG Commission I-ORG LGY2019022 O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31772736 O 31502062 O and O 31172327 O the O grants O from O the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC1600101 O and O 2017YFC1600103 O the O earmarked O fund O for O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-35 O and O the B-ORG Outstanding I-ORG youth I-ORG project I-ORG of I-ORG Natural I-ORG Science I-ORG Foundation I-ORG in I-ORG Hubei I-ORG Province I-ORG 2018CFA070 O This O work O was O supported O by O the O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG 973 I-ORG Program I-ORG of I-ORG China I-ORG 2015CB150302 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31772729 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0501201 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG 2017CFA020 O This O study O has O received O funding O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O China O grant O no. O S201301005689 B-AWARD the B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou O China O grant O no. O 201707010003 B-AWARD and O the B-ORG Special I-ORG Foundation I-ORG of I-ORG President I-ORG of I-ORG Nanfang I-ORG Hospital I-ORG Southern I-ORG Medical I-ORG University I-ORG grant O no. O 2016B026 B-AWARD This O study O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U2004126 O the O Tianjin B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 22JCZXJC00170 O 21JCZDJC00070 B-AWARD Research B-ORG Project I-ORG on I-ORG Skin I-ORG Injury I-ORG I-ORG Repair I-ORG BKJ21J016 O and O Tianjin B-ORG Key I-ORG Medical I-ORG Discipline I-ORG Specialty I-ORG Construction I-ORG Project I-ORG TJYXZDXK-043A O TPS O and O ZYW O have O been O supported O through O the O Air B-ORG Force I-ORG Office I-ORG of I-ORG Scientific I-ORG Research I-ORG grant O FA9550-16-1-0231 B-AWARD the O Army B-ORG Research I-ORG Office I-ORG grant O W911NF-17-1-0306 B-AWARD and O the O Office B-ORG of I-ORG Naval I-ORG Research I-ORG grant O N00014-17-1-2676 B-AWARD PK O and O PV O acknowledge O support O by O the O Advanced O Investigator O Award O of O the O European B-ORG Research I-ORG Council I-ORG Grant O No: O 341117 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 51579143 B-AWARD 61701299,51709167 B-AWARD the O Ministry O of O education O of O Humanities O and O Social O Science O project O Grant O No. O 15YJC630145 O the B-ORG Shanghai I-ORG Committee I-ORG of I-ORG Science I-ORG and I-ORG Technology O China O Grant O No. O 18040501700 B-AWARD and O the B-ORG Postgraduate I-ORG Innovation I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG Maritime I-ORG University I-ORG Grant O No. O 2017ycx030 B-AWARD 2016ycx042 B-AWARD This O study O was O made O possible O by O grants O from O the O Erasmus B-ORG MC I-ORG Health I-ORG Care I-ORG Efficiency I-ORG O Cost-Effectiveness O Research,http://www.erasmusmc.nl/research/over-research/subsidies/subsidies/?lang=en(project O number I-AWARD 2010-10112 O Stichting B-ORG Coolsingel I-ORG Rotterdam,http://stichtingcoolsingel.nl(project O number I-AWARD 255 O and O Erasmus B-ORG MC I-ORG Vriendenfonds,https://www.erasmusmcvrienden.nl/het-fonds/vriendenfonds(project O number I-AWARD 104117 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG CAPES O 88887.136367/2017-00 B-AWARD Conselho O Nacional O de O Pesquisa O CNPq O 465699/2014-6 O 445069/2014-7 O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo I-ORG FAPESP O 2013/00798-2 B-AWARD 2014/50938-8 O and O Fundação B-ORG de I-ORG Apoio I-ORG à I-ORG Pesquisa I-ORG do I-ORG Distrito I-ORG Federal I-ORG FAPDF O 193.000.653/2015 B-AWARD This O study O was O financially O supported O by O the O Yingkou B-ORG Enterprise I-ORG and I-ORG Doctor I-ORG Innovation I-ORG program I-ORG of I-ORG Yingkou I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG grant O number O 202005 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG grant O number O DUT21LK29 B-AWARD DUT20LK36 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 31670767 B-AWARD This O study O was O supported O by O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG Grant O No. O 3502Z20154033 B-AWARD the O Major/Important B-ORG Disease I-ORG Research I-ORG Project I-ORG Grant O No. O 3502Z20159022 B-AWARD and O the O Young/Middle-aged I-ORG Talent I-ORG Cultivation I-ORG Project I-ORG Grant O No. O 2015-ZQN-JC-44 B-AWARD The O authors O declare O no O competing O interest(s O Funding O for O this O research O was O provided O by O the O National O Institutes O of O Health O NIH O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG under O award O number O R42GM116622 B-AWARD the O NIH O National B-ORG Institute I-ORG of I-ORG Environmental I-ORG Health I-ORG Sciences I-ORG under O award O number O R44ES026269 B-AWARD and O the O National B-ORG Science I-ORG Foundation I-ORG NSF O Major O Research O Instrumentation O Program O under O award O number O 1530953 B-AWARD The O content O is O solely O the O responsibilities O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O NIH O or O the O NSF O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Program O No. O 51475136 B-AWARD Lingling O Li,http://www.nsfc.gov.cn O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG of O China O Program O No. O E2014202230 B-AWARD Lingling O Li,http://www.hensf.gov.cn O Hebei B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG Program O No. O 15212117),http://www.hebstd.gov.cn B-AWARD and O University B-ORG Innovation I-ORG Team I-ORG Leader I-ORG Program I-ORG of I-ORG Hebei I-ORG Province I-ORG Program O No. O LJRC003),http://www.hee.gov.cn B-AWARD This O research O was O funded O by O the O Scientific O Research O Funds O of O Huaqiao O University O Grant O number O 600005-Z18Y0016 O the O International O Science O and O Technology O Cooperation O and O Exchange O Fund O Projects O of O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG Grant O number O 2014DFE70230 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O Grant O number O 51261120374 O The O support O provided O by O the O Postgraduate O Research O and O Innovation O Project O of O Hunan O Province O Grant O number O CX2016B104 O the O Texas B-ORG Department I-ORG of I-ORG Transportation I-ORG Grant O number O No.0-6914 O and O the O scholarship O funded O by O China B-ORG Scholarship I-ORG Council I-ORG CSC O Grant O number O 201606130109 O are O gratefully O appreciated O This O work O was O supported O by O the O following O grants O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61772321 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2016FP07 B-AWARD the O Innovation O Foundation O of O Science O and O Technology O Development O Center O of O Ministry O of O Education O and O CERNET O Innovation B-ORG Foundation I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Center I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG and I-ORG New I-ORG H3C I-ORG Group I-ORG 2017A15047 O and O Innovation O Project O NGII20170508 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O No. O 61305102 B-AWARD provided O the O fund O for O the O remote O centre O of O motion O mechanism O design O and O machining O the O Open B-ORG Foundation I-ORG of I-ORG the I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Robotics I-ORG and I-ORG System I-ORG under O Grant O No. O SKLRS-2013-MS-02 B-AWARD helped O the O experiments O data O collection O and O analysis O and O the B-ORG fifty-fourth I-ORG batch I-ORG of I-ORG China I-ORG Postdoctoral I-ORG Science I-ORG Fund I-ORG under O Grant O No. O 2013M540247 B-AWARD supports O the O manuscript O writing O and O polishing O The O present O study O was O supported O by O Project B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Plan I-ORG in I-ORG Suzhou I-ORG SYSD2018138 O Project B-ORG of I-ORG Clinical I-ORG Expert I-ORG Team I-ORG Introduction I-ORG in I-ORG Suzhou I-ORG SZYJTD201807 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG 17ZR1438000 O This O work O was O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG Project I-ORG of I-ORG China I-ORG no. O 31301899 B-AWARD and O no. O 31501876 B-AWARD supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanxi I-ORG no. O 201601D021122 B-AWARD and O Shanxi B-ORG Agricultural I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG fund I-ORG projects I-ORG 2015YJ03 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31500087 O Science B-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG of I-ORG Shandong I-ORG Higher I-ORG Education I-ORG Institutions I-ORG J16LE03 O the O international B-ORG cooperation I-ORG grant I-ORG from I-ORG Henan I-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Agency I-ORG No. O 172102410060 B-AWARD and O Foundation B-ORG of I-ORG Henan I-ORG Educational I-ORG Committee I-ORG No. O 17B180008 B-AWARD This O work O was O supported O by O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81970805 B-AWARD Shanghai B-ORG Municipal I-ORG Health I-ORG Commission I-ORG grant O number O 202140183 B-AWARD Priority B-ORG Speciality I-ORG of I-ORG Shanghai I-ORG Huangpu I-ORG District I-ORG Commission I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG grant O number O HWZFK201803 B-AWARD This O research O was O financially O supported O by O the O Zhejiang B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Program I-ORG on I-ORG Agricultural I-ORG New I-ORG Variety I-ORG Breeding I-ORG 2021C02063-2 O China B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 31871597 B-AWARD and O The O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG National I-ORG Rice I-ORG Research I-ORG Institute I-ORG CNRRI-2020-02 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 31371996 B-AWARD and I-AWARD 31672081 B-AWARD Visiting B-ORG Scholar I-ORG Foundation I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Biocontrol I-ORG at I-ORG Sun I-ORG Yat-sen I-ORG University I-ORG Grant O No. O SKLBC12F01 B-AWARD Hangzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 20140432B01 B-AWARD and O the B-ORG Program I-ORG for I-ORG Excellent I-ORG Young I-ORG Teachers I-ORG in I-ORG Hangzhou I-ORG Normal I-ORG University I-ORG Grant O No. O JTAS B-AWARD 2011-01-031 O The O authors O acknowledge O the O financial O support O of O this O work O from O a O National O Post-Doctoral O Fellowship O NPDF O PDF/2016/001770 B-AWARD supported O by O the O funding O agency O Science B-ORG and I-ORG Engineering I-ORG Research I-ORG Board I-ORG SERB O Department O of O Science O and O Technology O DST O India O and O from O CLRI B-ORG Communication I-ORG Number—A/2020/CRE/GAP1614/1487 O This O research O was O also O supported O by O Basic O Science O Research O Program O through O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O funded O by O the O Ministry O of O Education O No. O 2022R1I1A1A01064416 B-AWARD and O the O Korea B-ORG Environment I-ORG Industry I-ORG I-ORG Technology I-ORG Institute I-ORG KEITI O through O a O project O for O developing O eco-friendly O new O materials O and O processing O technology O derived O from O wildlife O funded O by O the O Korea O Ministry O of O Environment O MOE O 2021003270006 O This O work O was O supported O by O the O Cabinet B-ORG Office I-ORG Government I-ORG of I-ORG Japan I-ORG SIP O Core B-ORG Research I-ORG for I-ORG Evolutional I-ORG Science I-ORG and I-ORG Technology I-ORG JPMJCR1502 O Exploratory B-ORG Research I-ORG for I-ORG Advanced I-ORG Technology I-ORG JPMJER1903 O New B-ORG Energy I-ORG and I-ORG Industrial I-ORG Technology I-ORG Development I-ORG Organization I-ORG P15009 O This O work O is O supported O by O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH O 2T32CA009001 B-AWARD D.E.H O and O Eunice B-ORG Kennedy I-ORG Shriver I-ORG National I-ORG Institute I-ORG of I-ORG Child I-ORG Health I-ORG and I-ORG Human I-ORG Development I-ORG NICHD O U01 B-AWARD HD072834 O LIFE-Moms O is O supported O by O NIH O through O the O National B-ORG Institute I-ORG of I-ORG Diabetes I-ORG and I-ORG Digestive I-ORG and I-ORG Kidney I-ORG Diseases I-ORG NIDDK O U01 B-AWARD DK094418 O U01 B-AWARD DK094463 O U01DK094416 B-AWARD 5U01 B-AWARD DK094466 I-AWARD RCU O the O National B-ORG Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute I-ORG NHLBI O U01 B-AWARD HL114344 O U01 B-AWARD HL114377 O the O NICHD O U01 O HD072834 O the O National O Center O for O Complementary O and O Integrative O Health O NCCIH O the O NIH O Office O of O Research O on O Women’s O Health O ORWH O the O Office O of O Behavioral O and O Social O Science O Research O OBSSR O the O NIH O Office O of O Disease O Prevention O ODP O the O Indian O Health O Service O the O Intramural O Research O Program O of O the O NIDDK O and O the O Office O of O the O Director O OD O NIH O The O PEARLS O study O was O partly O conducted O at O the O PRCTRC O Puerto O Rico O Clinical O and O Translational O Research O Consortium O funded O by O the O National B-ORG Institute I-ORG on I-ORG Minority I-ORG Health I-ORG and I-ORG Health I-ORG Disparities I-ORG of O the O NIH O under O award O number O U54MD007587 B-AWARD and O partly O funded O by O the O National O Institute O of O Minority O Health O and O Health O Disparities O under O award O number O G12MD007600 B-AWARD of O the O NIH O The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O National O Institutes O of O Health O This O work O was O financially O supported O by O the O 948 B-ORG Project I-ORG of I-ORG Ministry I-ORG of I-ORG Agriculture I-ORG of I-ORG China I-ORG grant O no. O 2015-Z45 B-AWARD the O Guangdong B-ORG Province I-ORG Innovation I-ORG Research I-ORG Team I-ORG Program I-ORG grant O no. O 201001D0104799318 B-AWARD the B-ORG China I-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG grant O no. O 2017M612399 B-AWARD the B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Henan I-ORG Province I-ORG grant O no. O 182102110427 B-AWARD and O the B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG Henan I-ORG Agricultural I-ORG University I-ORG grant O no. O KJCX2018A09 B-AWARD The O research O was O supported O by O Novartis B-ORG Pharmaceuticals I-ORG Corporation I-ORG I10288 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81670611 O and O the O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0901500 O Grants O for O this O study O was O provided O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG NNSF I-ORG of I-ORG China I-ORG Grant O No.31070347 O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG Grant O No. O 2011BAG07B05-3 B-AWARD the O Knowledge B-ORG Innovation I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Grant O No. O KSCX2-EW-Z-4 B-AWARD and O the O Special B-ORG Fund I-ORG for I-ORG Agro-scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Agriculture I-ORG of I-ORG China I-ORG Grant O No. O 201203086 B-AWARD to O DW, O the O State B-ORG Oceanic I-ORG Administration I-ORG of I-ORG China I-ORG Grant O No. O 201105011-3 B-AWARD and O NNSF B-ORG of I-ORG China I-ORG Grant O No. O 31170501 B-AWARD to O KXW O and O the O China B-ORG Scholarship I-ORG Council I-ORG Grant O No. O 2014)3026 B-AWARD to O ZTW O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O grants O from O The B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFD0050405 B-AWARD The O National O Key O Research O and O Development O Program O of O China O No. O 2017YFD0501705 B-AWARD Medical B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG No. O A2016306 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG No. O 2016A030307031 B-AWARD Natural O Science O Foundation O of O Guangdong O Province O China O No. O 2014A030307042 B-AWARD and O Key B-ORG Scientific I-ORG and I-ORG Technological I-ORG Project I-ORG of I-ORG Meizhou I-ORG People’s I-ORG Hospital I-ORG Guangdong I-ORG Province I-ORG China I-ORG No. O MPHKSTP-20170102 B-AWARD This O research O is O partially O supported O by O the O Research O Program O on O Emerging O and O Re-emerging O Infectious O Diseases O from O Japan B-ORG Agency I-ORG for I-ORG Medical I-ORG Research I-ORG and I-ORG Development O AMED O Grant O Number O 16fk0108202h1602 B-AWARD NO O JSPS B-ORG KAKENHI I-ORG Grant O Number O 15H05707 B-AWARD and O JST B-ORG CREST O Grant O Number O JPMJCR14D2 B-AWARD Japan O KA O All O the O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O Numbers O 2017YFD0500405 B-AWARD 2017YFD0501305 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Number O 31672548 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Henan I-ORG Province I-ORG Grant O Number O 162300410129 B-AWARD YI O was O supported O by O MEXT B-ORG KAKENHI I-ORG Grants-in-Aid I-ORG for I-ORG Innovative I-ORG Areas I-ORG ‘Memory I-ORG dynamism’ I-ORG Grant O Number O JP25115010 B-AWARD JSPS B-ORG KAKENHI I-ORG Grant-in-Aid I-ORG for I-ORG Scientific I-ORG Research I-ORG S) O Grant O Number O JP17H06113 B-AWARD and O UTokyo O Center O for O Integrative O Science O of O Human O Behavior O CiSHuB O M.T O was O supported O by O Grant-in-Aid B-ORG for I-ORG Young I-ORG Scientists I-ORG B) O Grant O Number O 25870172 B-AWARD Grant-in-Aid O for O Scientific O Research O C) O Grant O Number O 18K06055 O and O The O Naito O Foundation O TN O was O supported O by O Grant-in-Aid B-ORG for I-ORG JSPS I-ORG Research I-ORG Fellow I-ORG Grant O Number O 17J00339 B-AWARD The O URL O of O Japan O Society O for O the O Promotion O of O Science O ishttps://www.jsps.go.jp/english O The O URL O of O CiSHuB O ishttps://marler.c.u-tokyo.ac.jp/humanscience/en O The O URL O of O The O Naito O Foundation O ishttps://www.naito-f.or.jp/en O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O has O been O supported O in O part O by O the O Program O for O Promotion O of O Fundamental O Studies O in O Health O Sciences O conducted O from O the O National B-ORG Institute I-ORG of I-ORG Biomedical I-ORG Innovation I-ORG of O Japan O 10-43 O and I-AWARD 10-44 O the O Research O Funding O for O Longevity O Sciences O from O National B-ORG Center I-ORG for I-ORG Geriatrics I-ORG and I-ORG Gerontology O Japan O 23-9 O and I-AWARD 26-20 O and O KAKENHI O 24700290 O from O Japan B-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG This O work O was O supported O by O AIRCRAFT B-ORG 2016/19186 O the B-ORG Wellcome I-ORG Trust I-ORG 105614/Z/14/Z O Leukaemia B-ORG UK I-ORG 2016/JGF/0005 O the O Howat O Foundation O and O Friends O of O Paul O O’Gorman O S.D O is O a O recipient O of O University O of O Modena O and O Reggio O Emilia O PhD O studentship O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 22179103 B-AWARD 21676207 B-AWARD Donghai B-ORG Laboratory I-ORG Open-end I-ORG Fund I-ORG Zhoushan I-ORG China I-ORG grant O number O DH-2022KF0305 B-AWARD Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG grant O number O 2022A1515110456 B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG 973 I-ORG of I-ORG China I-ORG 2014CB541703 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 30871436 O 30973297 I-AWARD and I-AWARD 31171194 O Shandong B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Key I-ORG Program I-ORG 2009GG10002039 O Shenzhen B-ORG Committee I-ORG for I-ORG Technological I-ORG Renovation I-ORG ZDSY20120617112838879 O and O Shenzhen B-ORG Peacock I-ORG Plan I-ORG KQCX20130628112914292 O and O Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG ZR2013CQ041 O The O work O was O supported O by O JSPS B-ORG KAKENHI I-ORG Grants O 22K06431 O 18KT0071 B-AWARD and O 17K07110 B-AWARD JST B-ORG CREST I-ORG Grant O JPMJCR22P6 O and O JST B-ORG A-STEP I-ORG JPMJTR204C O This O work O was O supported O by O the O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG XDA13020504 O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG Grant O No. O 2013FY111200 B-AWARD and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31570314 O and O U1603231 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O is O supported O by O the O National B-ORG natural I-ORG fund I-ORG no. O 61503199 B-AWARD the O National B-ORG natural I-ORG science I-ORG key I-ORG fund I-ORG no. O 61533010 B-AWARD the O Jiangsu B-ORG Province I-ORG natural I-ORG science I-ORG fund I-ORG no. O BK20150853 B-AWARD the O Jiangsu B-ORG Province I-ORG high I-ORG school I-ORG natural I-ORG science I-ORG fund I-ORG no. O 15KJB120009 B-AWARD the O Ph.D B-ORG Programs I-ORG Foundation I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG no. O 20110142110036 B-AWARD NUPTSF B-ORG no. O NY214206 B-AWARD and O the O Open O Fund O grant O no. O XJKY14019 O This O work O was O supported O by O grants O from O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81503202 B-AWARD Hong B-ORG Kong I-ORG Macao I-ORG and I-ORG Taiwan I-ORG Science I-ORG I-ORG Technology I-ORG Cooperation I-ORG Program I-ORG of I-ORG China I-ORG No. O 2014DFH30010 B-AWARD Guangdong B-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG Feature I-ORG Innovation I-ORG Project I-ORG No. O 2016KTSCX018 B-AWARD Guangdong B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 2015A030310217 B-AWARD and O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2014A020221042 B-AWARD O 2013A022100001 B-AWARD This O work O is O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFA0506900 O the O National O Science O and O Technology O Major O Projects O for O Major B-ORG New I-ORG Drugs I-ORG Innovation I-ORG and I-ORG Develop I-ORG 2018ZX09711003-004-002 O Tsinghua B-ORG University I-ORG Initiative I-ORG Scientific I-ORG Research I-ORG Program I-ORG 20161080086 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81470839 O This O work O was O funded O in O part O by O National B-ORG Institute I-ORG of I-ORG Neurological I-ORG Disorders I-ORG and I-ORG Stroke I-ORG NIH O grants O F31NS092268 B-AWARD MY O R01NS085122 B-AWARD ET O National B-ORG Institute I-ORG of I-ORG Child I-ORG Health I-ORG and I-ORG Human I-ORG Development I-ORG NIH O R01HD58301 B-AWARD SVA O and O National B-ORG Institute I-ORG on I-ORG Disability I-ORG Independent I-ORG Living I-ORG and I-ORG Rehabilitation I-ORG Research I-ORG NIDILRR O grant O 90RE5021 B-AWARD SVA O The O work O was O supported O by O the O National B-ORG Social I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 17ZDA114 O the O Shanghai B-ORG Philosophy I-ORG Society I-ORG Planning I-ORG Youth I-ORG Project I-ORG 2020EJB006 O Shanghai B-ORG Pujiang I-ORG Program I-ORG 18PJC085 O This O research O was O funded O by O the O Characteristic B-ORG Innovation I-ORG Project I-ORG of I-ORG Colleges I-ORG University I-ORG in I-ORG Guangdong I-ORG Province I-ORG No. O 2020KQNCX025 B-AWARD the O Zhanjiang B-ORG Competitive I-ORG Allocation I-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Special O Fund O No. O 200915134541577 B-AWARD the O Guangdong B-ORG University I-ORG Student I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Project I-ORG 580520061 O the O Program B-ORG for I-ORG Scientific I-ORG Research I-ORG Start-up I-ORG Funds I-ORG of I-ORG Guangdong I-ORG Ocean I-ORG University I-ORG R19050 O and O the O Innovative B-ORG Team I-ORG Program I-ORG of I-ORG High I-ORG Education I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2021KCXTD021 O This O study O was O supported O by O The B-ORG Science I-ORG and I-ORG technology I-ORG Committee I-ORG Project I-ORG of I-ORG Pu I-ORG dong I-ORG New I-ORG Area I-ORG Shanghai I-ORG PKJ2016-Y31 O Outstanding B-ORG Medical I-ORG Talent I-ORG Training I-ORG Project I-ORG of I-ORG Health I-ORG System I-ORG of I-ORG Pudong I-ORG New I-ORG Area I-ORG Shanghai I-ORG PWRq2015-16 O Construction B-ORG Specialty I-ORG Project I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG Pudong I-ORG New I-ORG Area I-ORG Shanghai I-ORG PWZz2013-13 O This O work O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31701967 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG Grant O No. O LQ17C150003 B-AWARD and O the B-ORG young I-ORG talent I-ORG training I-ORG project I-ORG of I-ORG Zhejiang I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG 2016R23R08E05 O The O funding O bodies O had O no O roles O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O a O scholarship O from O the O China B-ORG Scholar I-ORG Council I-ORG and I-ORG Anhui I-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG gxfx2017006 O Science B-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG in I-ORG Anhui I-ORG province I-ORG 17030701031 O and O Anhui B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 1908085MC59 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Project O No.52004089 O 51976055 B-AWARD and O the O Excellent B-ORG Youth I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG Scientific I-ORG Committee O China O Project O No. O 2018JJ1011 B-AWARD and O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG of I-ORG Hunan I-ORG Province I-ORG No. O 2020RC4040 B-AWARD This O research O was O supported O by O the O Gedeon O Richter’s O Talentum O Foundation O 1103 O Budapest O Gyömrői O Str.19-21 O Thematic O Excellence O Program O 2021 O Health O Sub-program O of O the O Ministry B-ORG for I-ORG Innovation I-ORG and I-ORG Technology I-ORG in O Hungary O within O the O framework O of O the O EGA-16 B-AWARD project O of O the O University O of O Pécs O the O National B-ORG Research I-ORG Development I-ORG and I-ORG Innovation I-ORG Office I-ORG OTKA O K-134555 O and O the O National B-ORG Clinical I-ORG Neuroscience I-ORG Laboratory I-ORG RRF-2.3.1-21-2022-00011 O The O funding O sources O did O not O have O any O role O in O the O study O design O in O the O collection O analysis O and O interpretation O of O data O or O in O the O writing O and O submitting O of O this O manuscript O This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81771645 O and O 81471432 B-AWARD Scientific B-ORG Research I-ORG Foundation I-ORG of I-ORG Reproductive I-ORG and I-ORG Genetic I-ORG Hospital I-ORG of I-ORG CITIC-Xiangya I-ORG YNXM-201802 O and O Graduate B-ORG Research I-ORG and I-ORG Innovation I-ORG Projects I-ORG of I-ORG Central I-ORG South I-ORG University I-ORG Grant O 2017zzts372 O The O E-Risk O Study O is O funded O by O the O Medical B-ORG Research I-ORG Council I-ORG G1002190 O Additional O support O was O provided O by O National B-ORG Institute I-ORG of I-ORG Child I-ORG Health I-ORG and I-ORG Human I-ORG Development I-ORG HD077482 O Google O Streetview O British B-ORG Academy I-ORG SQ140024 O and O the O Jacobs O Foundation O J.N O received O a O Multidisciplinary O Studentship O from O the O Economic O and O Social O Research O Council O ESRC O L.A O is O the O Mental O Health O Leadership O Fellow O for O the O UK O ESRC O H.L.F O is O supported O by O an O MQ O Fellows O Award O MQ14F40 O C.L.O O is O a O Jacobs O Foundation O Advanced O Research O Fellow O and O a O Canadian O Institute O for O Advanced O Research O Fellow O This O work O was O supported O by O NIH B-ORG Grant O R01 O AG063544 B-AWARD to O T.Y.C O and O C.C.Y.C O We O acknowledge O the O shared O facilities O of O the O preclinical O Imaging O and O Microscopy O Resource O and O National O Cancer O Institute O Cancer O Center O Support O Grant O 5P30 B-AWARD CA023108-37 I-AWARD at O the O Norris B-ORG Cotton I-ORG Cancer I-ORG Center I-ORG at O Dartmouth O and O NIH O Grant O P20-GM113132 B-AWARD to O support O the O Institute O for O Biomolecular O Targeting O at O Dartmouth O Additional O funding O was O provided O by O a O National B-ORG Institute I-ORG on I-ORG Aging I-ORG Fellowship I-ORG F30 B-AWARD AG074524 I-AWARD to O M.T.D O This O research O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2017MF031 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 11704227 O and O the O Scientific B-ORG Research I-ORG Foundation I-ORG of I-ORG Shandong I-ORG University I-ORG of I-ORG Technology I-ORG 4041/416033 O This O work O was O supported O by O the O National B-ORG Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 71703025 B-AWARD 11871151 B-AWARD and O 71571046 O MOE B-ORG Ministry I-ORG of I-ORG Education I-ORG in I-ORG China I-ORG Project I-ORG of I-ORG Humanities I-ORG and I-ORG Social I-ORG Sciences I-ORG Grant O No. O 17YJC910004 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG in I-ORG China I-ORG Grant O No.2016J05172 O Social B-ORG Science I-ORG Planning I-ORG Project I-ORG of I-ORG Fujian I-ORG Province I-ORG in I-ORG China I-ORG Grant O No. O FJ2017C058 B-AWARD The O key O project O for O the O 2016 O annual O National O Social O Science O Fund O of O China O Grant O No. O 16AZD002 O Econometrics O Research O Innovation O Project O of O Fuzhou O University O in O China O Grant O No. O 602116 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG funded I-ORG project I-ORG 2016M602487 O Program B-ORG of I-ORG the I-ORG Pearl I-ORG River I-ORG Young I-ORG Talents I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG in I-ORG Guangzhou I-ORG China I-ORG 2013J2200042 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG S2012010009404 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Marie B-ORG Curie I-ORG Career I-ORG Integration I-ORG Grant O U-KARE O PCIG13-GA-2013-618162 O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG BBSRC O BB/L007223/1 B-AWARD BB/N00700X/1 B-AWARD BB/P006078/1 B-AWARD and O BB/P020194/1 B-AWARD Medical B-ORG Research I-ORG Council I-ORG MRC O MR/R005893/1 B-AWARD and O Queen's O University O Belfast O start-up O funds O This O research O was O supported O by O the O Major B-ORG Research I-ORG Plan I-ORG Grant O No. O 91648201 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 51575157 B-AWARD the O Self-Planned B-ORG Task I-ORG of I-ORG the I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Robotics I-ORG and I-ORG System I-ORG HIT I-ORG Grant O No. O SKLRS201816B B-AWARD and O Hebei B-ORG University I-ORG of I-ORG Technology I-ORG Joint O Training O Program O Grant O No.2017GN0008 O This O work O was O supported O in O part O by O project O of O Special O fund O from O promotion O and O demonstration O of O Tibet B-ORG financial I-ORG agricultural I-ORG science I-ORG and I-ORG technology I-ORG in O 2015 O Key O projects O of O the O Sichuan O Department O of O Education O 15ZA0005 O two-side O support O plan O of O Sichuan B-ORG Agricultural I-ORG University I-ORG 00770107 O and O the O Innovation B-ORG Program I-ORG of I-ORG Chinese I-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG ASTIP-IAS13 O This O project O was O supported O by O the B-ORG Health I-ORG Resources I-ORG and I-ORG Services I-ORG Administration I-ORG HRSA I-ORG of I-ORG the I-ORG U.S I-ORG Department I-ORG of I-ORG Health I-ORG and I-ORG Human I-ORG Services I-ORG HHS I-ORG under O grant O number O R40 B-AWARD MC I-AWARD 26816 I-AWARD and O title O “Etiological O subgroups O of O small-for-gestational-age O differential O child O outcomes” O for O grant O amount O 99,968.00 O 0% O financed O with O nongovernmental O sources O Li’s O effort O was O also O supported O by O the B-ORG China I-ORG Medical I-ORG Board I-ORG CMB I-ORG under O grant O number O 13-133 B-AWARD and O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O grant O number O 81302437 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O M.B O and O Z.L O are O supported O by O the O British B-ORG Heart I-ORG Foundation I-ORG FS/16/4/31831 O M.B O is O further O supported O by O the O British B-ORG Heart I-ORG Foundation I-ORG Centre I-ORG for I-ORG Vascular I-ORG Regeneration I-ORG RM/17/3/33381 O and O the O University B-ORG of I-ORG Edinburgh I-ORG BHF I-ORG Centre I-ORG of I-ORG Research I-ORG Excellence I-ORG RE/13/3/30183 O A.H.B O is O supported O by O the O British B-ORG Heart I-ORG Foundation I-ORG Chair I-ORG of I-ORG Translational I-ORG Cardiovascular I-ORG Sciences I-ORG CH/11/2/28733 O N.C.H O is O supported O by O a O Wellcome B-ORG Trust I-ORG Senior I-ORG Research I-ORG Fellowship I-ORG in I-ORG Clinical I-ORG Science I-ORG ref O 103749 B-AWARD This O study O is O supported O byJiangsu O Provincial I-ORG Medical I-ORG Youth I-ORG Talent(QNRC2016030),Grant O for I-ORG Science I-ORG and I-ORG Technology I-ORG Development(201605018 O andNational O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG CN)(81300490 O This O work O was O supported O in O part O by O Grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81572787 O 81672683 B-AWARD 81672993 B-AWARD 81772928 B-AWARD and O 81872278 B-AWARD the O Overseas B-ORG Expertise I-ORG Introduction I-ORG Project I-ORG for I-ORG Discipline I-ORG Innovation I-ORG 111 O Project I-AWARD No. I-AWARD 111-2-12 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG 2016JC2035 O 2017SK2105 B-AWARD 2018JJ3704 B-AWARD 2018JJ3815 B-AWARD 2018SK21210 B-AWARD 2018SK21211 B-AWARD and O 2019JJ50354 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81473450 B-AWARD 81302960 B-AWARD in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O the O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 7172148 B-AWARD in O collection O analysis O and O interpretation O of O data O the O Top B-ORG Young I-ORG Scientist I-ORG Funds I-ORG of I-ORG Beijing I-ORG University I-ORG of I-ORG Chinese I-ORG Medicine I-ORG No. O BUCM-2019-JCRC007 B-AWARD in O collection O of O data O as O well O as O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Public I-ORG Welfare I-ORG Research I-ORG Institutes I-ORG No. O YZ-1780 B-AWARD YZ-202021 O in O writing O the O manuscript O and O data O collection O This O work O has O been O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61872297 B-AWARD the O Seed B-ORG Foundation I-ORG of I-ORG Innovation I-ORG and I-ORG Creation I-ORG for I-ORG Graduate I-ORG Students I-ORG in O Northwestern O Polytechnical O University O Nos O ZZ2018170 B-AWARD ZZ2018235 B-AWARD China B-ORG National I-ORG Training I-ORG Programs I-ORG of I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG for I-ORG Undergraduates I-ORG No. O 201710699330 B-AWARD and O the O Program B-ORG of I-ORG Peak I-ORG Experience I-ORG of I-ORG Northwestern I-ORG Polytechnical I-ORG University I-ORG 2016 O The O design O of O this O study O involving O some O previous O investigations O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 71603182 O Data O extraction O was O financially O funded O by O the O Natural O Science O Foundation O of O China O 71774116 O The O analysis O and O interpretation O of O the O data O guided O by O the O statisticians O were O funded O by O the O Shanghai B-ORG Health I-ORG Policy I-ORG Program I-ORG 2018HP52 O and O the O writing O and O revision O including O the O language O improvement O were O supported O by O the O Shanghai O Health O Policy O Program O 2016HP043 O and O Shanghai B-ORG Excellent I-ORG Young I-ORG Talents I-ORG Project I-ORG in I-ORG Health I-ORG System I-ORG 2018YQ52 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31972370 O by O the O Special O Financial O Grant O from O the O China O Postdoctoral O Science O Foundation O 2017T100777 O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 2020JM-159 O by O the O National B-ORG key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG China I-ORG 2019YFD1000100 O and O by O the O General O Financial O Grant O from O China O Postdoctoral O Science O Foundation O 2016M592842 O We O are O grateful O for O support O received O from O several O funding O agencies O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG Grant O GM089740 B-AWARD to O MG O and O JMR O the O American B-ORG Heart I-ORG Association I-ORG Post-doctoral O Fellowship O 18POST33960587 B-AWARD to O PB) O and O the O National B-ORG Science I-ORG Foundation I-ORG Grant O MCB B-AWARD 1715823 I-AWARD to O DMZ O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20180772 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31800501 O and O Open B-ORG Foundation I-ORG of I-ORG Guangxi I-ORG Key I-ORG Laboratory I-ORG of I-ORG Clean I-ORG Pulp I-ORG I-ORG Papermaking I-ORG and I-ORG Pollution I-ORG Control I-ORG KF201725 O Grant O funding O received O from O National B-ORG Institute I-ORG of I-ORG Neurological I-ORG Disorders I-ORG and I-ORG Stroke O 1R01NS063226 B-AWARD 1R01NS076628 B-AWARD 1R21NS053684 B-AWARD and O 5U01NS094296 B-AWARD National B-ORG Eye I-ORG Institute O 1R01EY019500 B-AWARD National O Center O For O Advancing O Translational O Sciences O UL1 O TR000040 O National B-ORG Science I-ORG Foundation O 0954796 B-AWARD and O U.S B-ORG Department I-ORG of I-ORG Defense O MURI B-AWARD W911NF-12-1-0594 I-AWARD Hillman O National O Institute O of O General O Medical O Sciences O MSTP O T32 O GM007367 O Kozberg O and O Shaik O National O Institute O of O Neurological O Disorders O and O Stroke O F31 O NS084538 O 01 O Kozberg O National O Heart O Lung O and O Blood O Institute O F30 O HL128023 O 01 O Shaik O Support O was O provided O by: O Deutsche B-ORG Stiftung I-ORG für I-ORG Herzforschung I-ORG http://www.dshf.de/sitemap.php O F29/08 B-AWARD to O SK O and O UH: O financial O support O for O conductance O catheters O animals O and O salary O for O research O position O Else B-ORG Kröner-Fresenius-Stiftung I-ORG http://www.ekfs.de O P15/06/A79/05 B-AWARD to O UH O and O Fördergemeinschaft B-ORG Deutsche I-ORG Kinderherzzentren I-ORG http://www.kinderherzen.de O H-022.0039 B-AWARD to O UH O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Guangzhou I-ORG City I-ORG China I-ORG No. O 14570006 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81372409 O the B-ORG Sun I-ORG Yat-sen I-ORG University I-ORG Clinical I-ORG Research I-ORG 5010 I-ORG Program I-ORG No.2012011 O and O the O National O Natural O Science O Foundation O of O China O No. O 81402532 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31430091 O 31772890 O Strategic B-ORG Pilot I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Project I-ORG XDA08030202 O Project B-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Freshwater I-ORG Ecology I-ORG and I-ORG Biotechnology I-ORG 2016FBZ01 O The O funders O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21503104 O 21602094 B-AWARD 21502084 B-AWARD 21603092 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2016BQ20 O ZR2016BB11 B-AWARD ZR2016BQ35 B-AWARD and O Colleges B-ORG and I-ORG Universities I-ORG in I-ORG Shandong I-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG J16LC05 O J17KA097 B-AWARD This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81270602 B-AWARD Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2018JY0044 B-AWARD Chengdu B-ORG Science I-ORG and I-ORG Technology I-ORG Huimin I-ORG Project I-ORG of I-ORG China I-ORG Grant O No. O 2015-HM01-00307-SF B-AWARD We O are O thankful O for O research O grants O from O NICRA-ICAR B-ORG F. O No. I-AWARD 2-2(60)/10-11/NICRA O DBT-NEWS-India-UK B-ORG BT/IN/UK-VNC/44/NR/2015-531 O 16 O UKRI-GCRF B-ORG South I-ORG Asian I-ORG Nitrogen I-ORG Hub I-ORG SANH O NE/S009019/1 O and O GGSIPU B-ORG GGSIPU/DRC/FRGS/2018/22(1115 O including O a O fellowship O to O NS, O apart O from O his O earlier O UGC-NET O Fellowship O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O Grant O No.61803077 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province O Grant O No. O F2016501080 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities O Grant O No. O N172304024 B-AWARD This O study O was O supported O by O projects O RVO0517 B-AWARD from O the O Czech B-ORG Ministry I-ORG of I-ORG Agriculture O CZ.1.05/2.1.00/01.0006–ED0006/01/01 B-AWARD from O the O Czech B-ORG Ministry I-ORG of I-ORG Education I-ORG and O EU B-ORG project O 613574 B-AWARD ProHealth O All O the O financial O supports O are O correctly O mentioned O in O the O web O based O application O form O The O funders O of O RVO0517 O project O provided O partial O support O in O the O form O of O salary O for O authors O TK, O LDG O VB, O DC O and O IR. O Except O for O this O the O funders O did O not O have O any O additional O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O specific O roles O of O these O authors O are O articulated O in O the O ‘author O contributions’ O section O MY O is O supported O by O the O Singapore B-ORG National I-ORG Medical I-ORG Research I-ORG Council I-ORG Research O Fellowship O NMRC/Fellowship/0051/2017 O BSC O is O supported O by O UK B-ORG Medical I-ORG Research I-ORG Council I-ORG O Department O for O International O Development O Grant O ref O MR/K006924/1 B-AWARD and O the O UK B-ORG Department I-ORG of I-ORG Health I-ORG and I-ORG Social I-ORG Care I-ORG using O UK O Aid O funding O managed O by O the O NIHR O Grant O ref O PR-OD-1017-20006 B-AWARD The O views O expressed O in O this O publication O are O those O of O the O authors O and O not O necessarily O those O of O the O UK O Department O of O Health O and O Social O Care O or O the O Department O for O International O Development O CL O is O supported O by O the O Wellcome B-ORG Trust I-ORG 206736/Z/17/Z O The O Mahidol-Oxford O Tropical O Medicine O Research O Unit O is O supported O by O the O Wellcome O Trust-Mahidol O University-Oxford O Tropical O Medicine O Research O Programme O 106698 O This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD1000702/2018YFD1000700 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31971993 O the O Key-construction B-ORG Subject I-ORG Plan I-ORG of I-ORG Anhui I-ORG Province I-ORG WanJiaoMiKe[2014]28 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0300902 O the O Anhui B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Fund I-ORG 2008085MC73 O and O the O Key B-ORG Project I-ORG of I-ORG Natural I-ORG Science I-ORG Research I-ORG of I-ORG Anhui I-ORG Provincial I-ORG Education I-ORG Department I-ORG KJ2021ZD0108 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Research O reported O in O this O publication O was O supported O by O the O Albert O Einstein O Cancer O Center O Support O Grant O of O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG under O award O number O P30CA013330 B-AWARD and O the O Medical O Scientist O Training O Program O NIH O T32-GM007288 O J.C.M O is O supported O by O an O Australian B-ORG Research I-ORG Council I-ORG Future O Fellowship O FT170100047 O and O by O a O Metcalf B-AWARD Prize I-AWARD from O the O National B-ORG Stem I-ORG Cell I-ORG Foundation I-ORG of I-ORG Australia O The O funding O bodies O listed O did O not O play O a O role O in O the O design O of O the O study O the O collection O analysis O and O interpretation O of O the O data O nor O in O writing O the O manuscript O This O research O was O funded O by O the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2021YFA0805100 B-AWARD 2020YFC2003500 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 91939303 B-AWARD and O the B-ORG Beijing I-ORG Advanced I-ORG Innovation I-ORG Center I-ORG for I-ORG Big I-ORG Data-based I-ORG Precision I-ORG Medicine I-ORG Capital I-ORG Medical I-ORG University I-ORG Beijing I-ORG PXM2021_014226_000026 O This O was O supported O by O theNational O Institutes I-ORG of I-ORG Health/National O Institute I-ORG of I-ORG Neurological I-ORG Disorders I-ORG and I-ORG Stroke(R01NS097783 O K23NS080988 B-AWARD andNational O Institute I-ORG of I-ORG Aging(R01AG044838 O and O CTSA O award O No. O UL1TR000445 B-AWARD from O theNational O Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences O The O authors O declare O no O conflict O of O interest O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 52103152 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2021M690157 O 2022T150668 B-AWARD Ningbo B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2121J206 O This O work O is O supported O in O part O by O National B-ORG Science I-ORG Foundation I-ORG DBI1564756 O and O IIS1901191 B-AWARD to O YZ O National B-ORG Institute I-ORG of I-ORG Health I-ORG AI134678 O GM083107 B-AWARD and O GM136422 B-AWARD to O YZ O and O China B-ORG Scholarship I-ORG Council I-ORG 201606620076 O to O WZ O This O research O was O supported O by O European B-ORG Research I-ORG Council I-ORG ERC O 2015 O Advanced O Grant B-AWARD 495 I-AWARD AdG I-AWARD n. I-AWARD 695078 I-AWARD noMAGIC O A.M O G.T O the O LOEWE B-ORG initiative O iNAPO B-AWARD GT O Fondazione O CARIPLO O grant O 2014-0796 O by O MIUR O PRIN O Programmi O di O Ricerca O di O Rilevante O Interesse O Nazionale O 494 O 2015 O 2015795S5W O to O A.M O and O by O the O National O Science O Foundation O grant O no. O 1736030 B-AWARD JVE O This O work O was O supported O by O the O Directorate B-ORG for I-ORG Biological I-ORG Sciences I-ORG 1736030];European O Research O Council O Grant O 495 O AdG O n. O 695078];LOEWE O iNAPO O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O 81572654 B-AWARD the B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG Shenzhen I-ORG Innovation I-ORG Council I-ORG of I-ORG China I-ORG Grants O JCYJ20150403091443303 B-AWARD JCYJ20150403091443286 B-AWARD JCYJ2016042873933559 B-AWARD and O SZBC2017023 B-AWARD and O the B-ORG Sanming I-ORG Project I-ORG for I-ORG Medicine I-ORG in I-ORG Shenzhen I-ORG SZSM O 201512036 O Oral O and O Maxillofacial O Surgery O Team O Professor O Yu O Guangyan O Stomatology O Hospital O Peking O University O This O work O was O funded O by O the O grants O of O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG China I-ORG 2018YFC0310801 O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG NMST-KEXUE2017K01 O the O Senior O User O Project O of O RV O KEXUE O KEXUE2018G20 O and O KEXUE2019GZ02 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41806202 O and O the O Taishan O Scholar O Program O of O Shandong O Province O And O the O APC O was O funded O by O 2018YFC0310801 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 81570953 B-AWARD 81402235 B-AWARD 81700938 B-AWARD the O Tason B-ORG Stomatological I-ORG Development I-ORG Foundation I-ORG grant O numbers O 2015 B-AWARD and O the O Project B-ORG for I-ORG Culturing I-ORG Leading I-ORG Talents I-ORG in I-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG of I-ORG Beijing I-ORG grant O numbers O Z171100001117169 B-AWARD This O study O was O supported O by O a O grant O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81360004 B-AWARD 81760004 B-AWARD and O 31472191 B-AWARD grants O from O the O Ningxia B-ORG Science I-ORG and I-ORG Technology I-ORG Supporting I-ORG Program I-ORG to O Juan O Chen O and O Li O Zhu O grant O number O 2015s B-AWARD a O grant O from O the O Project B-ORG of I-ORG Postgraduate I-ORG Education I-ORG Innovation I-ORG Discipline I-ORG Construction I-ORG Program I-ORG of I-ORG Ningxia I-ORG China I-ORG grant O number O YXW B-AWARD 2017014 O and O a O grant O from O Ningxia B-ORG Medical I-ORG University I-ORG Scientific I-ORG Research I-ORG Project I-ORG grant O number O XY201702 B-AWARD These O funding O play O no O role O in O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O Strategic O Priority O Research O Program O of O the O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG XDB13040500 O to O W.Z O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 91731304 O to O W.Z O 91531303 B-AWARD to O G.W O 13th B-ORG Five-year I-ORG Informatization I-ORG Plan I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XXH13505-05 O to O Y.B O National B-ORG Key I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0901603 O to O W.Z O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC1201200 O to O B.T O International B-ORG Partnership I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG 153F11KYSB20160008 O Key O Technology O Talent O Program O of O the O Chinese O Academy O of O Sciences O to O W.Z O The O 100-Talent O Program O of O Chinese O Academy O of O Sciences O to O Y.B O Youth O Innovation O Promotion O Association O of O the O Chinese O Academy O of O Sciences O to O G.W O Funding O for O open O access O charge O Strategic O Priority O Research O Program O of O the O Chinese O Academy O of O Sciences O This O work O was O supported O by O the O National B-ORG Institute I-ORG on I-ORG Aging I-ORG grant O 1RC1AG035927 B-AWARD to O M. O Fabiani O https://www.nia.nih.gov O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health I-ORG grant O R56MH097973 B-AWARD to O GG O https://www.nimh.nih.gov/index.shtml O and O by O the O National B-ORG Center I-ORG for I-ORG Research I-ORG Resources I-ORG http://sdminutes.cit.nih.gov/about/almanac/organization/NCRR.htm O grant O S10RR029294 B-AWARD to O GG. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81903932 O 81803933 B-AWARD 81804017 B-AWARD and O 81903848 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG 19ZR1457500 O Shanghai B-ORG Youth I-ORG Science I-ORG and I-ORG Technology I-ORG Talents I-ORG Sailing I-ORG Plan I-ORG grant O number O 18YF1423500 B-AWARD and O the O Interdisciplinary B-ORG Project I-ORG of I-ORG “Clinical I-ORG Immunology I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine” I-ORG in I-ORG Shanghai I-ORG 30304113598 O E.S O was O supported O by O Harvard B-ORG University I-ORG Center I-ORG for I-ORG AIDS I-ORG Research I-ORG HU O CFAR I-AWARD NIH/NIAID I-AWARD fund I-AWARD 5P30AI060354-15 O L.M.B O was O supported O by O NIH/Fogarty B-ORG International I-ORG Center I-ORG R21TW011069 B-AWARD and O NIH/NIMH B-ORG P30MH058107 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O research O was O supported O by O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG grant O number O 31601328 B-AWARD 31571615 O to O FY O and O X. O Wu, O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O numbers O 2016YFD0300602 B-AWARD 2016YFD0300209 O to O WY, O and O Program B-ORG on I-ORG Industrial I-ORG Technology I-ORG System I-ORG of I-ORG National I-ORG Soybean I-ORG grant O number O CARS-04-PS19 B-AWARD to O WY. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O D.E.M O and O N.C O funded O by O The O Gordon B-ORG and I-ORG Betty I-ORG Moore I-ORG Foundation I-ORG Grant O 3420 B-AWARD and O NOAA B-ORG CIOERT I-ORG Award O NA14OAR4320260 B-AWARD C.E O Y.E O and O S.E.S O funded O by O Gordon O and O Betty O Moore O Foundation O Grant O 3420 O UC B-ORG San I-ORG Diego I-ORG Frontiers I-ORG of I-ORG Innovations I-ORG Scholarship I-ORG Program I-ORG This O study O was O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2018YFD1000200 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Fund I-ORG of I-ORG China I-ORG project O No. O 31872066 B-AWARD the B-ORG Innovation I-ORG Team I-ORG Project I-ORG of I-ORG the I-ORG Department I-ORG of I-ORG Education I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2016KCXTD O 011 O and O Guangzhou B-ORG science I-ORG and I-ORG technology I-ORG project I-ORG 201804020063 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 71803149 B-AWARD No. O 71573205 B-AWARD No. O 71673219 B-AWARD the O Ministry B-ORG of I-ORG Education I-ORG Humanities I-ORG and I-ORG Social I-ORG Science I-ORG Research I-ORG Youth I-ORG Fund I-ORG Project I-ORG No. O 18XJCZH005 B-AWARD No. O 19YJCZH094 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2019M653871XB B-AWARD and O the O Key O Industry O Chain O Project O of O Shaanxi O Technology O Committee O No. O 2019ZDLSF06-07 O This O study O was O financially O supported O by O the O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2012CB721003 B-AWARD the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2012AA022201C B-AWARD the O Shanghai B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 15ZR1408600 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 21276084 B-AWARD the O National B-ORG Major I-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG of I-ORG China I-ORG No. O 2012ZX09304009 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG No.2013ZR1412100 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31970178 O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Pathogen I-ORG and I-ORG Biosecurity I-ORG SKLPBS1802 O and O the O Beijing B-ORG Nova I-ORG Program I-ORG Z181100006218116 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O study O was O supported O by O research O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81873774 B-AWARD Shanghai B-ORG Rising-Star I-ORG Program I-ORG No. O 18QA1403800 B-AWARD Shanghai B-ORG Excellent I-ORG Young I-ORG Medical I-ORG Talents I-ORG Training I-ORG Program I-ORG No. O 2018YQ22 B-AWARD This O research O was O funded O within O the O Primary B-ORG Health I-ORG Care I-ORG Model I-ORG Program I-ORG through I-ORG the I-ORG Swiss I-ORG Contribution I-ORG Program I-ORG SH/8/1 I-ORG in O Hungary O under O reference O number O SH/8/1 B-AWARD 2012-17 O Manuscript O preparation O was O supported O by O the O Ministry B-ORG of I-ORG Innovation I-ORG and I-ORG Technology I-ORG of I-ORG Hungary I-ORG from O the O National O Research O Development O and O Innovation O Fund O research O project O no. O K B-AWARD 138372 O and O financed O by O the O K_21 O funding O scheme O The O APC O was O funded O by O the O Erasmus B-ORG program I-ORG of I-ORG the I-ORG European I-ORG Commission I-ORG aimed O at O Medical O Education O on O Medically O Unexplained O Symptoms O and O Intercultural O Communication O under O grant O number O /MUSIC/Nr O 2018-2021.2018-1-NL01_KA203-038971 B-AWARD Funded O by O 1. O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of O China(grant O no. O 31401933).http://www.nsfc.gov.cn/english/site_1/index.html B-AWARD Funder O Tang O Chuanhong O provides O the O resource O of O strain O G0119 O and O the O Genomic O analysis O data O 2. O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG grant O no. O 2014CB138301 B-AWARD Funder O Zhang O Xiaoyu O provides O the O idea O of O this O study O and O manuscript O revising.http://www.most.gov.cn/eng/programmes1/200610/t20061009_36223.htm O 3. O Shanghai B-ORG Agriculture I-ORG Scientific I-ORG Development I-ORG Program I-ORG grant O no. O G2014070107 B-AWARD Funder O Tang O Chuanhong O provides O the O resource O of O strain O G0119 O and O the O Genomic O analysis O data O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31000356 B-AWARD the O Presidential B-ORG Foundation I-ORG of I-ORG the I-ORG Tianjin I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG No. O 13002 B-AWARD and O Tianjin B-ORG Research I-ORG Program I-ORG of I-ORG Application I-ORG Foundation I-ORG and I-ORG Advanced I-ORG Technology I-ORG for I-ORG Youths I-ORG 14JCQNJC14800 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31601803 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG Central I-ORG Non-profit I-ORG Scientific I-ORG Institution I-ORG No. O 1610132020032 B-AWARD and O the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS20 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O is O supported O by O the B-ORG Foundation I-ORG of I-ORG Guangzhou I-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG 202102010253 O Guangdong B-ORG Demonstration I-ORG Base I-ORG for I-ORG Joint I-ORG Training I-ORG of I-ORG Graduate I-ORG Students I-ORG 20201 O Open B-ORG Project I-ORG Fund I-ORG of I-ORG the I-ORG Sixth I-ORG Affiliated I-ORG Hospital I-ORG of I-ORG Guangzhou I-ORG Medical I-ORG University I-ORG 2020-11-370 O and O Project B-ORG of I-ORG Guangzhou I-ORG Municipal I-ORG Health I-ORG Bureau I-ORG 20201A010051 O This O study O was O supported O by O the O National B-ORG Key I-ORG Technology I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2015BAD23B04-2 O Special O Funds O for O Scientific B-ORG Research I-ORG on I-ORG Public I-ORG Causes I-ORG 201503120 O Shanxi B-ORG Collaborative I-ORG Innovation I-ORG Center I-ORG of I-ORG High I-ORG Quality I-ORG and I-ORG Efficient I-ORG Production I-ORG of I-ORG Specialty I-ORG Crops I-ORG on I-ORG Loess I-ORG Plateau I-ORG J241643D30 O and O the O Fund O for O Shanxi B-ORG “1331 I-ORG Project” I-ORG Shanxi I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Team I-ORG Project I-ORG 201605D131041 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Nature I-ORG Scientific I-ORG Foundation I-ORG of I-ORG China I-ORG grant O nos O 61561036 B-AWARD and O 61702290 B-AWARD Program B-ORG for I-ORG Young I-ORG Talents I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG in I-ORG Universities I-ORG of I-ORG Inner I-ORG Mongolia I-ORG Autonomous I-ORG Region I-ORG NJYT-18-B01 O and O Fund B-ORG for I-ORG Excellent I-ORG Young I-ORG Scholars I-ORG of I-ORG Inner I-ORG Mongolia I-ORG 2017JQ04 O The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O and O nor O in O the O decision O to O publish O or O in O the O preparation O of O the O manuscript O This O work O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81501675 O 81871565 B-AWARD 81571908 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2016B090916001 O the O Sun B-ORG Yat-sen I-ORG University I-ORG Clinical I-ORG Research I-ORG 5010 I-ORG Program I-ORG 2013001 O 2018003 B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81272897 O the O Science B-ORG and I-ORG Technology I-ORG Foundation I-ORG of I-ORG the I-ORG Guangdong I-ORG Province I-ORG 2014A050503029 O and O the O Sun B-ORG Yat-sen I-ORG Initiative I-ORG Program I-ORG for I-ORG Scientific I-ORG Research I-ORG YXQH201701 O The O funders O played O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O YW O wishes O to O thank O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O U1704103 B-AWARD the O China B-ORG Scholarship I-ORG Council I-ORG 201708410311 O and O the O Sci-tech B-ORG Innovation I-ORG Foundation I-ORG of I-ORG Henan I-ORG Agricultural I-ORG University I-ORG grant O no. O KJCX2016A06 B-AWARD for O supporting O the O research O The O funding O bodies O played O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O grants O from O the B-ORG National I-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG People’s I-ORG Republic I-ORG of I-ORG China I-ORG 81502852 O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Y19H260021 O and I-AWARD Y15H190006 O and O the B-ORG Independent I-ORG Task I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG for I-ORG Diagnosis I-ORG and I-ORG Treatment I-ORG of I-ORG Infectious I-ORG Diseases I-ORG Nos O 2017ZZ10 B-AWARD and I-AWARD 2018ZZ06 O This O project O was O supported O in O part O by O an O Australian B-ORG Research I-ORG Council I-ORG Discovery I-ORG Projects I-ORG grant O DP130101141 O and O funding O from O The O University O of O Queensland O Australia O to O LGC O and O the O College B-ORG of I-ORG Life I-ORG Science I-ORG Shanxi I-ORG University I-ORG China I-ORG to O YPL O National O Serial O Number O of O Postdoctoral O Fellowship O 140975 B-AWARD Some O specimens O were O collected O on O field O trips O funded O by O an O Australian B-ORG Biological I-ORG Resources I-ORG Study I-ORG grant O RF212-52 O to O LGC O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O sponsored O by O the O Science B-ORG and I-ORG Technology I-ORG Base I-ORG and I-ORG Talent I-ORG Project I-ORG of I-ORG Guangxi I-ORG Province I-ORG Gui O Ke I-AWARD AD19245059 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangxi I-ORG Province I-ORG 2019GXNSFBA245062 O High-level B-ORG Talents I-ORG Scientific I-ORG Research I-ORG Start-Up I-ORG Fund I-ORG Project I-ORG of I-ORG Beibu I-ORG Gulf I-ORG University I-ORG 2019KYQD15 O Guangxi B-ORG Middle-aged I-ORG and I-ORG Young I-ORG Teachers’ I-ORG Basic I-ORG Ability I-ORG Promotion I-ORG Project I-ORG 2019KY0464 O Guangxi B-ORG Key I-ORG Laboratory I-ORG of I-ORG Beibu I-ORG Gulf I-ORG Marine I-ORG Biodiversity I-ORG Conservation I-ORG 2021ZC02 O ASEAN B-ORG Talent I-ORG Program I-ORG ATYSP2022008 O and O Marine B-ORG Science I-ORG Program I-ORG for I-ORG Guangxi I-ORG First-Class I-ORG Discipline I-ORG Beibu I-ORG Gulf I-ORG University I-ORG TRA001 O DRA002 I-AWARD ESB010 O This O work O was O supported O by O the O National B-ORG GMO I-ORG New I-ORG Variety I-ORG Breeding I-ORG Program I-ORG of I-ORG PRC I-ORG 2014ZX0801102B-003 O the O National B-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG of I-ORG China I-ORG 31501849 O 31471958 I-AWARD 31772510 O and O the O Open B-ORG Project I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG for I-ORG Biology I-ORG of I-ORG Plant I-ORG Diseases I-ORG and I-ORG Insect I-ORG Pests I-ORG SKLOF201306 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH,https://www.nih.gov O grants O GM089740-01A1 B-AWARD M.G O and O J.M.R O National B-ORG Science I-ORG Foundation I-ORG NSF,https://www.nsf.gov O grant O MCB B-AWARD 1715823 I-AWARD D.M.Z O and O American B-ORG Heart I-ORG Association I-ORG AHA,https://www.heart.org O Post-doctoral O Fellowship O 18POST33960587 B-AWARD P.B O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0901502 O Beijing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG Z151100003915126 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81570061 O This O work O was O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hainan I-ORG Province I-ORG No. O 317170 O Shenzhen B-ORG Dapeng I-ORG Special I-ORG Project I-ORG for I-ORG Industrial I-ORG Development I-ORG No. O PT20170302 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81560611 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O the O National B-ORG Science I-ORG Foundation I-ORG Funds I-ORG 81872966 O the O National B-ORG Science I-ORG I-ORG Technology I-ORG Fundamental I-ORG Resources I-ORG Investigation I-ORG Program I-ORG of I-ORG China I-ORG 2018FY100705 O the O National B-ORG Mega-Project I-ORG for I-ORG Innovative I-ORG Drugs I-ORG of I-ORG China I-ORG 2019ZX09735-002 O and O the O Chinese B-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG the I-ORG Innovation I-ORG Funds I-ORG for I-ORG Medical I-ORG Sciences I-ORG CIFMS O 2021-I2M-1-022 O The O funders O were O not O involved O in O the O study O design O data O collection O or O analysis O decision O to O publish O or O manuscript O preparation O The O fluorescence O spectroscopy O UV–vis O absorption O fluorescence O probe O experiments O synchronous O fluorescence O circular O dichroism O CD) O spectra O and O three-dimensional O spectra O study O was O funded O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81403177 O and O the B-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Shenyang I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG F12-277-1-14 O The O molecular O docking O study O was O funded O by O Innovation B-ORG Team I-ORG Project I-ORG of I-ORG the I-ORG Education I-ORG Department I-ORG of I-ORG Liaoning I-ORG Province I-ORG LT2015011 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO. O 81760428 B-AWARD NO. O 81960435 B-AWARD and O NO. O 81460363 B-AWARD Start-up B-ORG Project I-ORG of I-ORG High-level I-ORG Talents I-ORG Scientific I-ORG Research I-ORG in I-ORG Shihezi I-ORG University I-ORG RCZK2018C19 O Science B-ORG and I-ORG Technology I-ORG Development I-ORG Project I-ORG of I-ORG Xinjiang I-ORG Production I-ORG and I-ORG Construction I-ORG Corps I-ORG NO. O 2018AB033 B-AWARD National B-ORG Early I-ORG Detection I-ORG and I-ORG Treatment I-ORG Project I-ORG for I-ORG Upper I-ORG Digestive I-ORG Tract I-ORG in I-ORG Rural I-ORG Area I-ORG in I-ORG China I-ORG NO. O 2018 O and O The B-ORG Youth I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Leading I-ORG Talents I-ORG Project I-ORG of I-ORG Corps I-ORG NO. O 2017CB004 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O research O start-up O fellowship O of O university O of O sunshine O coast O to O Min O Zhao O The O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31871339 B-AWARD 31801120 B-AWARD Guangdong B-ORG High I-ORG School I-ORG Young I-ORG Innovative I-ORG Talents I-ORG Project I-ORG No. O 2015KQNCX136 B-AWARD Guangdong B-ORG Science I-ORG Research I-ORG Program I-ORG General I-ORG Project I-ORG No. O 20170710123 B-AWARD and O Guangzhou B-ORG Municipal I-ORG Scientific I-ORG Research I-ORG Project I-ORG No. O 1201630073 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 11847009 B-AWARD the O China B-ORG Association I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG Youth I-ORG Talent I-ORG Promotion I-ORG Project I-ORG 2022QNRC001 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG of I-ORG China I-ORG No. O 22KJB580005 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Project O no. O 81972508 B-AWARD 82172738 B-AWARD the O Talents B-ORG Training I-ORG Program I-ORG of I-ORG Pudong I-ORG Hospital I-ORG affiliated I-ORG to I-ORG Fudan I-ORG University I-ORG Project O no. O PX202001 B-AWARD and O the O Scientific B-ORG Research I-ORG Foundation I-ORG provided I-ORG by I-ORG Pudong I-ORG Hospital I-ORG affiliated I-ORG to I-ORG Fudan I-ORG University I-ORG Project O no. O YJRCJJ201906 B-AWARD This O study O was O funded O by O The B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O number O 2016YFC0502905 B-AWARD awarded O to O Prof O Zhibiao O Chen),The O National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 41371512 B-AWARD awarded O to O Prof O Zhiqiang O Chen O and O The B-ORG Key I-ORG Project I-ORG to I-ORG Guide I-ORG Social I-ORG Development I-ORG of I-ORG Fujian I-ORG Province I-ORG China I-ORG grant O number O 2016Y0024 B-AWARD awarded O to O Prof O Zhibiao O Chen O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O University B-ORG of I-ORG Wisconsin I-ORG Carbone I-ORG Cancer I-ORG Center I-ORG Support O Grant O NIH O P30CA014520 B-AWARD This O work O was O also O supported O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG R01AI13479 O R33CA225281 B-AWARD R01CA186134 B-AWARD to O D.J.B O R01CA185747 B-AWARD R01 B-AWARD CA205101 O R01 B-AWARD CA211082 I-AWARD to O M.C.S O K99ES028744 B-AWARD to O B.P.J O and O the O Department B-ORG of I-ORG Defense I-ORG DOD O W81XWH-16-1-0514 B-AWARD to O J.M.L O This O study O was O supported O by O the B-ORG Medical I-ORG Health I-ORG Technology I-ORG Project I-ORG for I-ORG Guangzhou I-ORG 20181A011051 O and O the B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Guangzhou I-ORG 201804010093 O and O the B-ORG Project I-ORG for I-ORG Key I-ORG Medicine I-ORG Discipline I-ORG Construction I-ORG of I-ORG Guangzhou I-ORG Municipality I-ORG 2017-2019-07 O Yeda-Sela O Center O for O Basic O Research O European B-ORG Research I-ORG Council I-ORG NOVCARBFIX O 646827 B-AWARD Israel B-ORG Science I-ORG Foundation I-ORG 740/16 O Beck-Canadian O Center O for O Alternative O Energy O Research O R.M O is O the O Charles O and O Louise O Gartner O professional O chair O N.A O is O supported O by O the O Human B-ORG Frontier I-ORG Science I-ORG Program I-ORG LT000546/2018-L O Funding O for O open O access O charge O Yeda-Sela O Center O for O Basic O Research O European O Research O Council O NOVCARBFIX O 646827 O Israel O Science O Foundation O 740/16 O Beck-Canadian O Center O for O Alternative O Energy O Research O R.M O is O the O Charles O and O Louise O Gartner O professional O chair O N.A O is O supported O by O the O Human O Frontier O Science O Program O LT000546/2018-L O This O work O was O supported O by O grants O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grants O 31470246 B-AWARD and O 31300659 B-AWARD Scientific B-ORG Research I-ORG and I-ORG Innovation I-ORG Team I-ORG of I-ORG Sichuan I-ORG Province I-ORG Grant O 15TD0025 B-AWARD Preeminent B-ORG Youth I-ORG Fund I-ORG of I-ORG Sichuan I-ORG Province I-ORG Grant O 2015JQO019 B-AWARD and O Huimin B-ORG Project I-ORG of I-ORG Chengdu I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG Grant O 2015-HM01-00543-SF B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Sichuan I-ORG Provincial I-ORG Education I-ORG Department I-ORG Grant O 15ZB0239 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Chengdu I-ORG Medical I-ORG College I-ORG Grant O CYZ11-008 B-AWARD The O authors O gratefully O acknowledge O the O financial O support O provided O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 11502163 B-AWARD 11702187 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Tianjin I-ORG grant O numbers O 17JCQNJC03000 B-AWARD 16JCZDJC36600 B-AWARD 18JCQNJC72600 B-AWARD Research B-ORG Project I-ORG of I-ORG Tianjin I-ORG Municipal I-ORG Education I-ORG Committee I-ORG grant O number O 2017ZD05 B-AWARD and O the O Program O for O Innovative O Research O Team O at O the O University O of O Tianjin O TD13-5043 O FWC O was O supported O by O National O Institutes O of O Health O grants O from O the O Eunice O Kennedy O Shriver O National B-ORG Institute I-ORG of I-ORG Child I-ORG Health I-ORG and I-ORG Human I-ORG Development I-ORG DP2OD022614 B-AWARD National B-ORG Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences I-ORG grant O KL2 B-AWARD TR000140 O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health I-ORG P30MH062294 B-AWARD the O Yale O Center O for O Clinical O Investigation O and O the O Yale O Center O for O Interdisciplinary O Research O on O AIDS O The O Estonian B-ORG Ministry I-ORG of I-ORG Education I-ORG and I-ORG Research I-ORG under O grant O TARTH15017I B-AWARD to O AU. O RH O was O also O supported O by O the O National O Institute O of O Mental O Health O P30MH062294 O The O RDS O study O was O funded O by O the O National B-ORG Institute I-ORG on I-ORG Drug I-ORG Abuse I-ORG grant O 1R01DA029888 B-AWARD to O RH/ O AU O Co-PIs O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 81601010 B-AWARD 81701039 B-AWARD Key B-ORG Disciplines I-ORG Group I-ORG Construction I-ORG Project I-ORG of I-ORG Pudong I-ORG Health I-ORG Bureau I-ORG of I-ORG Shanghai I-ORG PWZxq2017-08 O and O Clinical B-ORG Peak I-ORG Discipline I-ORG Construction I-ORG Project I-ORG of I-ORG Pudong I-ORG New I-ORG Area I-ORG Government I-ORG PWYgf2018-05 O The O authors O gratefully O acknowledge O the O support O for O this O research O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31970755 O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG LY21C120001 O and O Key B-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG Jinhua I-ORG City I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG 2021-3-146 O and O 2020XG-09 B-AWARD This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG I-ORG Development I-ORG R&D I-ORG plan I-ORG 2017YFD0201600 O the B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG CAAS-ASTIP-IVFCAAS O the B-ORG Key I-ORG Laboratory I-ORG of I-ORG Horticultural I-ORG Crops I-ORG Genetic I-ORG Improvement I-ORG Ministry I-ORG of I-ORG Agriculture I-ORG in I-ORG China I-ORG IVF2017ZF01 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31701753 O These O funding O sources O supported O the O publication O of O this O work O and O data O analysis O while O had O no O role O in O study O design O data O collection O and O analysis O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82203987 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutes I-ORG of I-ORG China I-ORG 22KJB330009 O the O Suzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Plan I-ORG Livelihood I-ORG Technology I-ORG Project I-ORG SS202009 O and O the O Suzhou B-ORG Health I-ORG Personnel I-ORG Training I-ORG Project I-ORG GSWS2020120 O This O work O was O financially O supported O by O the O Department B-ORG of I-ORG Scientific I-ORG Research I-ORG project I-ORG in I-ORG Heilongjiang I-ORG province I-ORG No. O LH2022B022 B-AWARD Jiamusi B-ORG University I-ORG horizontal I-ORG research I-ORG project I-ORG No. O 20210428001 B-AWARD No. O 2021040301 B-AWARD The B-ORG young I-ORG talent I-ORG innovation I-ORG project I-ORG of I-ORG the I-ORG education I-ORG department I-ORG of I-ORG Heilongjiang I-ORG province I-ORG of I-ORG China I-ORG Grants O No.UNPYSCT-2018114 O This O research O was O supported O by O grants O from O the O ESRC B-ORG ES/R003041/1 O and O the O Wellcome B-ORG Trust I-ORG WT094836AIA O to O Courtenay O F. O Norbury O and O a O British B-ORG Academy I-ORG Visiting I-ORG Fellowship I-ORG awarded O to O Shaun O K.Y O Goh O VF1/101436 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O research O reported O here O was O funded O by O grant O 2014CB942803 B-AWARD from O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China O grant O 31490593 B-AWARD from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O and O grant O 2016-MDB-KF-13 B-AWARD from O the O funds O of O the B-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Molecular I-ORG Developmental I-ORG Biology I-ORG This O work O was O supported O by O China B-ORG National I-ORG Key I-ORG Project I-ORG Grant I-ORG http://www.most.gov.cn O Grant O No. O 2016YFD0100102 B-AWARD and O Dongfa O Sun O was O the O host O of O this O project O This O work O was O also O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG http://www.nsfc.gov.cn O Grant O No. O 31601294 B-AWARD and O Longqing O Sun O was O the O host O of O this O project O This O work O was O also O supported O by O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG http://www.chinapostdoctor.org.cn O Grant O No. O 2015M582241 B-AWARD and O Longqing O Sun O was O the O host O of O this O project O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundations I-ORG of I-ORG China I-ORG 81571874 O and O 81501705 B-AWARD the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK2014134 O and O the B-ORG Jiangsu I-ORG Provincial I-ORG Medical I-ORG Talent I-ORG ZDRCA2016082 O This O work O was O supported O by O the O Laboratory B-ORG of I-ORG Lingnan I-ORG Modern I-ORG Agriculture I-ORG Project I-ORG NZ2021031 O the O Guangzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG 202002020050 O the O Research O Group O Construc-tion O Project O of O Guangdong B-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG 202109TD O the O Program O for O Guangdong B-ORG YangFan I-ORG Introducing I-ORG Innovative I-ORG and I-ORG Entrepreneurial I-ORG Teams I-ORG 2017YT05H045 O Guangdong B-ORG Province I-ORG Citrus I-ORG Mango I-ORG System I-ORG 2022KJ108 O and O the O Special O Fund O for O Scientific B-ORG In-novation I-ORG Strategy-Construction I-ORG of I-ORG High I-ORG Level I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Science I-ORG R2020QD-033 O This O work O was O funded O by O Precision B-ORG Targeted I-ORG Intervention I-ORG Studies I-ORG among I-ORG High I-ORG Risk I-ORG Groups I-ORG for I-ORG HIV I-ORG Prevention I-ORG in I-ORG China I-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG 2018ZX10721102 O the B-ORG key I-ORG Project I-ORG of I-ORG Philosophy I-ORG and I-ORG Social I-ORG Sciences I-ORG Research I-ORG in I-ORG Jiangsu I-ORG Education I-ORG Department I-ORG 2018SJZDI123 O the B-ORG Nantong I-ORG Municipal I-ORG Bureau I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG MS12018001 O Postgraduate B-ORG Research I-ORG I-ORG Practice I-ORG Innovation I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG KYCX18_2432 O The O funders O had O no O roles O in O the O study O design O collecting O data O the O analysis O and O interpretation O of O data O or O writing O the O manuscript O The O present O research O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31170922 B-AWARD National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG No. O 2012cb619103 B-AWARD the O Research B-ORG Fund I-ORG for I-ORG the I-ORG Doctoral I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG No. O 20120181110058 B-AWARD and O Program B-ORG for I-ORG New I-ORG Century I-ORG Excellent I-ORG Talents I-ORG in I-ORG University I-ORG NCET-12-0387 O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 62275022 B-AWARD and O No. O 62275017 B-AWARD the O Beijing B-ORG Municipal I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O No. O 4222017 B-AWARD and O the O funding B-ORG of I-ORG foundation I-ORG enhancement I-ORG program I-ORG Grant O No. O 2020-JCJQ-JJ-030 B-AWARD The O funders O had O no O role O in O the O experiment O design O data O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O authors O acknowledge O the O funding O from O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31601745 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Youth I-ORG in I-ORG Jiangsu I-ORG Province I-ORG BK20160579 O and O Aarhus B-ORG University I-ORG Research I-ORG Foundation I-ORG AUFF O grant O 30379 B-AWARD This O study O was O financed O in O part O by O the B-ORG Coordenação I-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior—Brasil I-ORG CAPES)—Finance O Code O 001 B-AWARD and O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG do I-ORG Amazonas I-ORG FAPEAM O Grant O 001/2019-PROPG-CAPES/FAPEAM B-AWARD In O addition O this O research O was O partially O funded O by O the B-ORG Fundação I-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo I-ORG FAPESP I-ORG Centro I-ORG de I-ORG Desenvolvimento I-ORG de I-ORG Materias I-ORG Funcionais I-ORG CDMF O Grant O 2013/07296-2 B-AWARD and O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq O Grant O 314.810/2021-8 B-AWARD This O work O was O supported O by O Yunnan B-ORG Science I-ORG and I-ORG Technology I-ORG Talent I-ORG and I-ORG Platform I-ORG Program I-ORG 2017HC019 O Yunnan B-ORG Joint I-ORG Support I-ORG for I-ORG National I-ORG Program I-ORG 2015GA009 O Yunnan B-ORG Province I-ORG Major I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 2017ZF007 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O U1702282 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O cross-disciplinary O cooperation O project O of O Beijing B-ORG Science I-ORG and I-ORG Technology I-ORG Nova I-ORG Z191100001119015 O Fertility O Research O Program O of O Young O and O Middle-aged O Physicians O in O 2021 O Beijing B-ORG Health I-ORG Promotion I-ORG Association I-ORG BJHPA-2021-SHZHYXZHQNYJ-010 O and O Discipline B-ORG Leader I-ORG Program I-ORG Beijing I-ORG Obstetrics I-ORG and I-ORG Gynecology I-ORG Hospital I-ORG Capital I-ORG Medical I-ORG University I-ORG XKDTR201804 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 11471336 O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2017ZX10201101 O Guangxi B-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG AB16380213 O Guangxi O Bagui O Honor O Scholarship O and O Chinese O State O Key O Laboratory O of O Infectious O Disease O Prevention O and O Control O This O work O was O supported O by O the O Jiangsu B-ORG Province I-ORG Natural I-ORG Science I-ORG Foundation I-ORG for I-ORG Youths I-ORG BK20170993 O BK20170997 B-AWARD the O Jiangsu B-ORG Synergetic I-ORG Innovation I-ORG Center I-ORG for I-ORG Advanced I-ORG Bio-Manufacture I-ORG XTE1840 O the O Project B-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Materials-Oriented I-ORG Chemical I-ORG Engineering I-ORG KL16-08 O the O Key O Science O and O Technology O Project O of O Jiangsu O Province O BE2016389 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 21706125 O No. B-AWARD 21727818 O No. B-AWARD 21706124 O No. B-AWARD 31700092 O This O research O was O funded O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG NO. O 2021FZZX001-11 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grants O 12132015 B-AWARD 11872333 B-AWARD and O 11802270 B-AWARD and O the O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of O China O Grant O LR19A020001 B-AWARD This O work O was O funded O by O Spain’s B-ORG Ministerio I-ORG de I-ORG Ciencia I-ORG e I-ORG Innovación-FEDER I-ORG grant O BFU2015-65037-P B-AWARD and O Generalitat B-ORG Valenciana I-ORG grants O GRISOLIAP/2018/005 B-AWARD and O PROMETEO2019/012 B-AWARD to O SFE O RG O was O supported O by O Ministerio O de O Ciencia O e O Innovación-FEDER O contract O BES-2016-077078 B-AWARD This O work O was O supported O by O the O National B-ORG Support I-ORG Program I-ORG 2014BAI01B01 O awarded O to O Dr. O Pan O the O Yunnan B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 2013CA005 O awarded O to O Dr. O Pan O and O the O Yunnan B-ORG Province I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 2016NS012 O awarded O to O Dr. O Ruan O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O The B-ORG Swedish I-ORG Cancer I-ORG Society I-ORG 130452 O to O Y.W O The B-ORG Cancer I-ORG Society I-ORG of I-ORG Stockholm I-ORG 131242 O to O Y.W O The B-ORG Swedish I-ORG Cancer I-ORG and I-ORG Traffic I-ORG Accident I-ORG Foundation I-ORG F-C-001225 O to O Y.W O and O The B-ORG Swedish I-ORG Society I-ORG for I-ORG Medical I-ORG Research I-ORG SLS O 50514 I-AWARD to O H.R O The O project O described O was O supported O by O Award O Numbers O R01DA026472 B-AWARD R01MH086523 B-AWARD and O R01AA018330 B-AWARD from O the O National B-ORG Institute I-ORG on I-ORG Drug I-ORG Abuse I-ORG NIDA O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health I-ORG NIMH O and O National B-ORG Institute I-ORG on I-ORG Alcohol I-ORG Abuse I-ORG and I-ORG Alcoholism I-ORG NIAAA O Dr. O Spartaco O Santi O was O supported O by O grants O from O the O Ministero B-ORG della I-ORG Salute O Conto O Capitale I-AWARD 2013 O Rizzoli O Orthopaedic O Institute O Dr. O Filippo O Piccinini O was O supported O by O a O European B-ORG Molecular I-ORG Biology I-ORG Organization I-ORG EMBO O Heidelberg O Germany O short O term O fellowship O EMBO O ASTF I-AWARD 233-2015 O The O authors O gratefully O acknowledge O funding O from O the O Associazione B-ORG Italiana I-ORG per I-ORG la I-ORG Ricerca I-ORG sul I-ORG Cancro-AIRC O grant O MFAG-16491 O P.I O Serena O Duchi O and O support O from O “5 O per O mille O 2014” O O Rizzoli O Orthopaedic O Institute O The O funders O had O no O role O in O this O study O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31270084 O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG No. O 2012CB721005 O and O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2012AA022107 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O grants O from O the O Major B-ORG Science I-ORG and I-ORG Technology I-ORG Special I-ORG Project I-ORG of I-ORG China I-ORG 2017ZX09304016 O 2017ZX10302201004008 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81971949 O and O the O Clinical B-ORG Research I-ORG Startup I-ORG Program I-ORG of I-ORG Southern I-ORG Medical I-ORG University I-ORG by I-ORG High-level I-ORG University I-ORG Construction I-ORG Funding I-ORG of I-ORG Guangdong I-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG LC2016PY003 O This O work O is O financed O by O national O funds O from O FCT—Fundação B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG a I-ORG Tecnologia O I.P O in O the O scope O of O the O project O UIDP/04378/2020 B-AWARD and O UIDB/04378/2020 B-AWARD of O the O Research O Unit O on O Applied O Molecular O Biosciences—UCIBIO O and O the O project O LA/P/0140/2020 B-AWARD of O the O Associate O Laboratory O Institute O for O Health O and O Bioeconomy—i4HB O This O work O is O also O funded O by O Fundação B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG Tecnologia I-ORG in O the O scope O of O the O project O 2022.04315.PTDC B-AWARD CRR O was O funded O by O FCT—Fundação B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG Tecnologia/MCTES O grant O number O SFRH/BPD/124612/2016 B-AWARD This O work O was O supported O by O the O Education B-ORG Fund I-ORG of I-ORG Macao I-ORG SAR I-ORG Government I-ORG CP-UMAC-2020-01 O the B-ORG University I-ORG of I-ORG Macau I-ORG MYRG O 2020-00067-FHS O MYRG2019-00082-FHS B-AWARD MYRG2018-00081-FHS B-AWARD CRG2021-00001-ICI B-AWARD and O the O Macao B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Fund I-ORG FDCT O 0020/2019/AMJ I-AWARD and O FDCT B-AWARD 0011/2018/A1 O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO. O 31260400 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Province I-ORG NO. O 20122BAB214003 B-AWARD and O Science B-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG of I-ORG Jiangxi I-ORG Province I-ORG NO. O 20132BBG70045 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 51602170 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Qinghai I-ORG China I-ORG Grant O No.2016-ZJ-954Q O and O the O Youth B-ORG Science I-ORG Foundation I-ORG of I-ORG Qinghai I-ORG Normal I-ORG University I-ORG Grant O No. O 2019zr003 B-AWARD This O study O was O supported O by O the O Slovak B-ORG National I-ORG Grant I-ORG Agency I-ORG VEGA B-AWARD 2/0030/17 O VEGA B-AWARD 1/0127/20 I-AWARD and O Miniatura B-AWARD 2017/01/X/NZ8/01607 I-AWARD Polish O NCN O as O well O as O by O the O statutory O funds O of O the O University O of O Łódž O Tomasz O Mamos O was O supported O by O the O Scholarship B-ORG of I-ORG the I-ORG Polish I-ORG National I-ORG Agency I-ORG for I-ORG Academic I-ORG Exchange I-ORG NAWA I-ORG at I-ORG Bekker I-ORG Programme I-ORG project O nb. O PN/BEK/2018/1/00225 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O is O supported O by O an O European B-ORG Research I-ORG Council I-ORG Consolidator O Grant O ERC-2017-COG O 771057 I-AWARD WELL-BEING I-AWARD PI O Bartels O Data O collection O in O the O NTR O was O supported O by: O NWO B-ORG large O investment O 480-15-001/674 O Netherlands O Twin O Registry O Repository O researching O the O interplay O between O genome O and O environment O The O Netherlands O Organization O for O Scientific O Research O Grant O No. O NWO-MW O 904-61-193 O and O the O Addiction O programme O of O ZonMW B-ORG Grant O No. O 31160008 B-AWARD This O paper O was O financially O supported O by O the O Technological B-ORG Agency I-ORG of I-ORG Czech I-ORG Republic I-ORG under O no. O TE01020445 B-AWARD the O Czech B-ORG Science I-ORG Foundation I-ORG under O No. O GAČR B-AWARD 15–05259S O the O Grant B-ORG Agency I-ORG of I-ORG Charles I-ORG University I-ORG project O No. O 1054213 B-AWARD and O student B-ORG project I-ORG SVV–2016–260325 B-AWARD The O study O was O supported O by O Six B-ORG Talent I-ORG Peaks I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG NY-042 O Jiangsu B-ORG Province I-ORG Three I-ORG New I-ORG Forestry I-ORG Projects I-ORG LYSX[2016]53 O and O the O 333 B-ORG Talents I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BRA2017498 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O received O support O from O the B-ORG general I-ORG project I-ORG of I-ORG National I-ORG Social I-ORG Science I-ORG Fund I-ORG Grant O No. O 19BJL131 B-AWARD the B-ORG base I-ORG project I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG Grant O No. O 17JJD790024 B-AWARD and O the B-ORG Ministry I-ORG of I-ORG Education's I-ORG Innovation I-ORG Team I-ORG Development I-ORG Plan I-ORG project I-ORG Grant O No. O IRT_17R52 B-AWARD Grant O recipient O JW. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O National B-ORG Scientific I-ORG Research I-ORG Fund I-ORG of I-ORG China I-ORG grant O number O 81671077 B-AWARD Beijing B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG grant O Z161100002616013 B-AWARD and O “One B-ORG Hundred I-ORG Advantage I-ORG Projects” I-ORG Fund I-ORG of I-ORG Chinese I-ORG PLA I-ORG General I-ORG Hospital I-ORG grant O number O YS201414 B-AWARD The O funding O organizations O for O this O study O were O not O involved O in O any O aspect O of O the O study O design O enrollment O of O participants O collection O and O analysis O of O data O interpretation O of O the O results O nor O the O writing O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31700580 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hainan I-ORG province I-ORG 319MS093 O the O Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG for I-ORG Chinese I-ORG Academy I-ORG of I-ORG Tropical I-ORG Agricultural I-ORG Sciences I-ORG 1630052017011 O and O 1630022019017 B-AWARD and O the O Research B-ORG Fund I-ORG of I-ORG Guangdong I-ORG University I-ORG of I-ORG Petrochemical I-ORG Technology I-ORG 2018rc55 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the B-ORG Jiangsu I-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Fund I-ORG CX(13)5085 O the B-ORG Central I-ORG Finance I-ORG Agricultural I-ORG Extension I-ORG Project I-ORG TG(15)075 O the B-ORG “Six I-ORG Talent I-ORG Peak” I-ORG Funded I-ORG Projects I-ORG of I-ORG Jiangsu I-ORG Province I-ORG 2015-NY-043 O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Nantong I-ORG MS12016044 O the B-ORG National I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC31701341 O the B-ORG China I-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017T100648 O and O Shenzhen O Overseas I-ORG Talents I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Funding I-ORG Scheme I-ORG The O Peacock I-AWARD Scheme O Development B-ORG and I-ORG Collaborative I-ORG Innovation I-ORG Center I-ORG of I-ORG Shanghai I-ORG No. O ZF1205 B-AWARD Shanghai B-ORG Engineering I-ORG Research I-ORG Center I-ORG of I-ORG Plant I-ORG Germplasm I-ORG Resources I-ORG 17DZ2252700 O the O United O States O National B-ORG Science I-ORG Foundation I-ORG IOS-0923312 O IOS-1539831 B-AWARD This O research O was O funded O by O the O Xiamen B-ORG Health I-ORG Commission I-ORG project I-ORG 2022D006 O 2020CXB055 B-AWARD Xiamen B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Project I-ORG NO. O 3502Z20227291 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No O 82270988 B-AWARD 82071128 B-AWARD and O 81671001 B-AWARD This O study O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFC1308900 B-AWARD Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 7161002 B-AWARD and O Capital’s B-ORG Funds I-ORG for I-ORG Health I-ORG Improvement I-ORG and I-ORG Research I-ORG No. O 2016-1-1021 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 22105103 B-AWARD and O No. O 12102194 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20200471 O and O BK20210353 B-AWARD the O Joint B-ORG Funds I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U2141202 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2021M690134 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 30920041106 B-AWARD The O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81471843 B-AWARD 81571874 B-AWARD 81671892 B-AWARD and O 81670074 B-AWARD Jiangsu B-ORG Provincial I-ORG Key I-ORG Medical I-ORG Discipline I-ORG Laboratory O No. O ZDXKA2016025 B-AWARD the B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BE2018743 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG and I-ORG the I-ORG Research I-ORG Innovation I-ORG Program I-ORG for I-ORG College I-ORG Graduates I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O KYZZ16_0129 B-AWARD This O work O is O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31771913 O and O 31401638 B-AWARD Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BE2016629 O and O the O National B-ORG First-class I-ORG Discipline I-ORG Program I-ORG of I-ORG Light I-ORG Industry I-ORG Technology I-ORG and I-ORG Engineering I-ORG LITE2018-08 O This O study O was O supported O by O the O Science B-ORG and I-ORG Technology I-ORG Foundation I-ORG of I-ORG Tianjin I-ORG Municipal I-ORG Health I-ORG Bureau I-ORG No. O 2015KZ055 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Foundation I-ORG of I-ORG Tianjin I-ORG Stomatological I-ORG Hospital I-ORG No. O 2019BSZD02 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81870763 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 52061006 O the O Guangxi B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2020GXNSFAA159122 O 2018JJB160017 B-AWARD the O Guangxi B-ORG Key I-ORG Laboratory I-ORG of I-ORG Information I-ORG Materials I-ORG 201010-Z O and O the O Opening B-ORG Project I-ORG of I-ORG Guangxi I-ORG Key I-ORG Laboratory I-ORG of I-ORG Calcium I-ORG Carbonate I-ORG Resources I-ORG Comprehensive I-ORG Utilization I-ORG HZXYKFKT201906 O This O study O was O supported O by O the B-AWARD Strategic I-AWARD Research I-AWARD Promotion I-AWARD Program I-AWARD from O Yamaguchi B-ORG University O the B-AWARD Translational I-AWARD Research I-AWARD Program I-AWARD from O Yamaguchi B-ORG University I-ORG Hospital O and O the B-AWARD Pancreatic I-AWARD Disease I-AWARD Research I-AWARD Award I-AWARD from O the O Pancreas B-ORG Research I-ORG Foundation I-ORG of I-ORG Japan I-ORG This O research O was O funded O by O theMedical O Research I-ORG Council(MRC O and O Sackler O Prize O MR/K50127X/1 O awarded O to O JAH O TheDepartment O of I-ORG Health I-ORG Policy I-ORG Research I-ORG Program(Policy O Research O Unit O in O Behaviour O and O Health O PR-UN-0409-10109 O andNational O Institute I-ORG for I-ORG Health[NF-SI-0513-10101 O awarded O to O TMM O This O report O is O independent O research O commissioned O and O funded O by O the O National O Institute O for O Health O Research O Policy O Research O Programme O The O views O expressed O in O this O publication O are O those O of O the O author(s O and O not O necessarily O those O of O the O NHS O the O National O Institute O for O Health O Research O the O Department O of O Health O and O Social O Care O or O its O arm's O length O bodies O and O other O Government O Department O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81771653 B-AWARD 81501187 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Province I-ORG No. O 1508085QH173 B-AWARD and O the O Anhui B-ORG Public I-ORG Welfare I-ORG Technology I-ORG Application I-ORG Research I-ORG Linkage I-ORG Plan I-ORG Project I-ORG No. O 1704f0804019 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0200503 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21777144 O 21577128 B-AWARD H.W O Paerl O was O supported O by O the O US B-ORG National I-ORG Science I-ORG Foundation I-ORG 1831096 O Centralised O pooling O checking O and O data O analysis O were O supported O by O Cancer B-ORG Research I-ORG UK I-ORG grant O numbers O C8221/A19170 B-AWARD and O C8221/A29017 B-AWARD Eleanor O L. O Watts O is O supported O by O the O Nuffield O Department O of O Population O Health O Early O Career O Research O Fellowship O Aurora O Perez‐Cornago O is O supported O by O a O Cancer O Research O UK O Population O Research O Fellowship O C60192/A28516 O and O by O the O World B-ORG Cancer I-ORG Research I-ORG Fund I-ORG WCRF O UK O as O part O of O the O World O Cancer O Research O Fund O International O grant O programme O 2019/1953 O ATBC O was O supported O in O part O by O the O Intramural O Research O Program O of O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG and O the O National B-ORG Cancer I-ORG Institute O CARET O is O funded O by O the O National O Cancer O Institute O National O Institutes O of O Health O through O grants O U01‐CA063673 B-AWARD UM1‐CA167462 B-AWARD R01‐CA B-AWARD 78812 I-AWARD and O U01‐CA167462 B-AWARD CLUE O is O funded O by O the O American O Institute O for O Cancer O Research O NIH O Grants O IU01AG18033 B-AWARD and O IU01CA86308 B-AWARD HIMS O was O supported O by O research O grants O from O the O National O Health O and O Medical O Research O Council O of O Australia O MEC O is O supported O by O the O US O National O Institutes O of O Health O grant O U01 B-AWARD CA164973 O JACC O study O was O supported O by O Grants‐in‐Aid O for O Scientific O Research O from O the O Ministry O of O Education O Culture O Sports O Science O and O Technology O MEXT O of O Japan O RMM O was O supported O by O the O NIHR O Biomedical O Research O Centre O at O University O Hospitals O Bristol O and O Weston O NHS O Foundation O Trust O and O the O University O of O Bristol O RMM O was O supported O by O a O Cancer O Research O UK O C18281/A29019 O programme O grant O the O Integrative O Cancer O Epidemiology O Programme O The O views O expressed O are O those O of O the O author(s O and O not O necessarily O those O of O the O NIHR O or O the O Department O of O Health O and O Social O Care O This O work O was O supported O by O the O Joint B-ORG Fund I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG and O the O Karst O Science O Research O Center O of O Guizhou O Province O No. O U1812401 O the O National O Natural O Science O Foundation O of O China O grant O no. O 32160656 B-AWARD the O Science-Technology B-ORG Support I-ORG Program I-ORG of I-ORG Guizhou I-ORG Province I-ORG grant O no. O 2020)1Y134 B-AWARD 2021 B-AWARD YB243 O the O “Hundred” B-ORG Level I-ORG Talent I-ORG Foundation I-ORG of I-ORG Guizhou I-ORG Province I-ORG grant O no. O GCC B-AWARD 2022]023-1 O and O the O Cultivation B-ORG Program I-ORG of I-ORG Guizhou I-ORG University I-ORG grant O no. O 2019]09 B-AWARD This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81720108002 O Jiangsu B-ORG Province’s I-ORG Medical I-ORG Elite I-ORG Programme I-ORG ZDRCA2016022 O Project B-ORG of I-ORG National I-ORG Key I-ORG Clinical I-ORG Specialty I-ORG Jiangsu I-ORG Provincial I-ORG Special I-ORG Program I-ORG of I-ORG Medical I-ORG Science I-ORG BL2014086 O and O BE2017751 B-AWARD and O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG 2018ZX09734007 O This O research O is O supported O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of O China O grant O no. O 2016-JL-010 B-AWARD and O China B-ORG Scholarship I-ORG Council I-ORG CSC O grant O no. O 201706950020 B-AWARD to O Z.X O and O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NS099261 O and O the O American B-ORG Heart I-ORG Association I-ORG 15SDG25960005 O to O S.H O The O work O reported O herein O was O supported O by O the O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81630099 O No.81773706 O and O No.81573403 O the O key B-ORG project I-ORG of I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Higher I-ORG Education I-ORG Institutions I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O 15KJA310002 B-AWARD and O the O Foundation B-ORG Research I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG The O Natural O Science O Fund O No. O BK20170564 B-AWARD This O work O was O supported O by O the O grants O from O the O earmarked O fund O for O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-35 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31671327 O and O 31772556 B-AWARD the O Program B-ORG for I-ORG Changjiang I-ORG Scholar I-ORG and I-ORG Innovation I-ORG Research I-ORG Team I-ORG in I-ORG University I-ORG Grant O No. O IRT_15R621 B-AWARD Major B-ORG Project I-ORG of I-ORG Selection I-ORG for I-ORG New I-ORG Livestock I-ORG and I-ORG Poultry I-ORG Breeds I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2016C02054-5 O and O Beijing B-ORG Innovation I-ORG Consortium I-ORG of I-ORG Agriculture I-ORG Research I-ORG System I-ORG BAIC02-2016 O This O research O was O supported O by O the O Diamond O Research O Grant O grant O PAR-2560-04663 B-AWARD to O NJ O Faculty B-ORG of I-ORG Medicine I-ORG Chiang I-ORG Mai I-ORG University I-ORG and O the O Bio O O Medical O Technology O Development O Program O of O the O National O Research O Foundation O NRF O funded O by O the O Ministry B-ORG of I-ORG Science I-ORG I-ORG ICT I-ORG South I-ORG Korea I-ORG grant O 2017M3A9E4070707 B-AWARD to O NJ O In O addition O we O acknowledge O Chiang O Mai O University O for O providing O the O budget O for O our O Excellence O Center O in O Insect O Vector O Study O grant O number O 2562 B-AWARD to O NJ O This O research O was O funded O by O the O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG PDA O MOP-106573 B-AWARD RJS O MOP–93696 B-AWARD the O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health I-ORG GH: O R01 B-AWARD MH101493 O R01 B-AWARD MH085321 O and O the O Ontario B-ORG Brain I-ORG Institute I-ORG OBI O IDS-I B-AWARD l-02 O OBI O is O an O independent O non-profit O corporation O funded O partially O by O the O Ontario O government O The O opinions O results O and O conclusions O are O those O of O the O authors O and O no O endorsement O by O the O Ontario O Brain O Institute O is O intended O or O should O be O inferred O Bioinformatic O analyses O were O supported O in O part O by O the O Canadian O Centre O for O Computational O Genomics O C3G O part O of O the O Genome O Technology O Platform O GTP O funded O by O Genome O Canada O through O Genome O Quebec O and O Ontario O Genomics O ALT O MB O and O Genome O Canada O through O Ontario O Genomics O ALT O SC, O MB, O and O RW O Dr. O Paul O D. O Arnold O receives O support O from O the O Alberta O Innovates O Translational O Health O Chair O in O Child O and O Youth O Mental O Health O Funding O was O provided O by O National B-ORG Key I-ORG R&D I-ORG program I-ORG of I-ORG China I-ORG 2018YFA0107500 O 2018YFC1704300 B-AWARD the B-ORG MAECI I-ORG Italy-China I-ORG Science I-ORG and I-ORG Technology I-ORG Cooperation I-ORG #PGR00961 O National B-ORG Natural I-ORG Science I-ORG of I-ORG China I-ORG Programs I-ORG 81571612 O 81530043 B-AWARD 31601106 B-AWARD 31771641 B-AWARD 81861138015 B-AWARD the B-ORG Scientific I-ORG Innovation I-ORG Project I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Science I-ORG XDA16020403 O This O study O was O funded O by O The O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC)-Regional I-ORG Science I-ORG Fund I-ORG Grant O Nos O 31860397 B-AWARD and O 31360296 B-AWARD the O open B-ORG Project I-ORG of I-ORG the I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Crop I-ORG Stress I-ORG Biology I-ORG for I-ORG Arid I-ORG Areas I-ORG of I-ORG China I-ORG CSBAAKF2018006 O and O the O Key B-ORG Program I-ORG of I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Gansu I-ORG Province I-ORG in I-ORG China I-ORG 22JR5RA228 O This O work O was O supported O by O the O National B-ORG Cancer I-ORG Institute I-ORG 1R41CA210857-01A1];National O Institute I-ORG of I-ORG Neurological I-ORG Disorders I-ORG and I-ORG Stroke I-ORG R01NS098772];National O Institute I-ORG on I-ORG Drug I-ORG Abuse I-ORG R01DA042852 O This O research O was O supported O by O Panzhihua B-ORG Science I-ORG and I-ORG technology I-ORG plan I-ORG projects I-ORG no. O 2014CY-G-28 B-AWARD Sichuan B-ORG Youth I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Team I-ORG Project I-ORG no. O 2015TD0008 B-AWARD and O the O authors O also O acknowledged O the O funding O from O the O 2018 B-ORG Youth I-ORG Innovation I-ORG Project I-ORG from I-ORG Shenzhen I-ORG Polytechnic I-ORG no. O 601822K42012 B-AWARD KL O is O supported O by O Canada O NSERC B-ORG grant O 435666-2013 B-AWARD DN O is O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG grant O DMS1313224 B-AWARD and O by O the O National O Institute O of O General O Medical O Science O NIGMS O of O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG and O the O joint O National O Science O Foundation/NIGMS O Mathematical O Biology O Program O grant O R01GM109458 B-AWARD This O work O was O supported O by O the B-ORG State I-ORG Key I-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG of I-ORG China I-ORG grant O no. O 31330060 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC)-Shandong I-ORG Joint I-ORG Fund I-ORG for I-ORG Marine I-ORG Science I-ORG Research I-ORG Centers I-ORG grant O no. O U1606403 B-AWARD the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG grant O no. O 201762028 B-AWARD This O research O was O funded O by O the O National O Key O Research O O Development O Program O of O China O under O grant O No. O 2017YFB0306103 O the O 111 B-ORG Project I-ORG under O grant O No. O B17002 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O under O grant O No. O 51590894 B-AWARD National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG under O grant O No. O 2017-Ⅵ-0010-0081 B-AWARD and O the O Key O Research O O Development O Plan O of O Jiangxi O Province O under O grant O No.20181ACH80009 O This O work O was O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Inner I-ORG Mongolia O grant O number O 2019MS08112 B-AWARD Inner B-ORG Mongolia I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG Study O on I-AWARD Epidemiological I-AWARD Characteristics I-AWARD and I-AWARD Its I-AWARD Key I-AWARD Techniques I-AWARD for I-AWARD Prevention I-AWARD and I-AWARD Control I-AWARD of I-AWARD Brucellosis I-AWARD and I-AWARD Q I-AWARD fever O and O Research B-ORG Innovation I-ORG Subsidy I-ORG Project I-ORG for I-ORG Graduate I-ORG Students I-ORG of I-ORG Inner I-ORG Mongolia O grant O number O S2018112013Z B-AWARD These O funding O played O roles O in O the O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O in O this O study O This O study O was O supported O by O Kuwait B-ORG University I-ORG KU) I-ORG Research I-ORG Sector I-ORG Grant O MR01/14 O KU, B-ORG HSC I-ORG OMICS I-ORG Research I-ORG Unit I-ORG Grant O GM01/15 O KU B-ORG General I-ORG Facilities I-ORG Science I-ORG GF-S I-ORG Faculty I-ORG of I-ORG Science I-ORG Grants O GS01/03 O GS01/05 B-AWARD and O GS02/10 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O 81701465 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG under O Grant O LY17H040008 B-AWARD and O the O Chinese B-ORG Medicine I-ORG Research I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Province I-ORG CN) O under O Grant O 2018ZA079 B-AWARD This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81660404 B-AWARD the B-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG provincial I-ORG department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG grant O No. O 20201ZDG02007 B-AWARD and O Foundation B-ORG of I-ORG Jiangxi I-ORG Educational I-ORG Committee I-ORG grant O No. O GJJ170016 B-AWARD All O funders O provided O support O to O authors O and O paid O the O fee O for O statistical O analysis O This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China O grant O number O 2019YFC1605000 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 31801482 B-AWARD and O the O National B-ORG Laboratory I-ORG of I-ORG Biomacromolecules O grant O number O 2018kf09 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51501002 B-AWARD the O University B-ORG Synergy I-ORG Innovation I-ORG Program I-ORG of I-ORG Anhui I-ORG Province I-ORG GXXT-2022-083 B-AWARD Anhui B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2208085ME103 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31901372 O the O Natural O Science O Foundation O of O Jiangsu O University O 18KJA220002 O the O Jiangsu O Province O Science O and O Technology O Project O SZ-SQ2018017 O SZ-SQ2018018 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20190758 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2019M661851 O and O the O National O Key O Research O O Development O Program O of O China O 2017YFD0600204 O The O study O was O funded O by O a O EU B-ORG Framework I-ORG Program I-ORG 6 I-ORG STREP I-ORG project O Malaria O age O exposure O Project O reference O 18902 B-AWARD the O Spanish B-ORG Ministerio I-ORG de I-ORG Ciencia I-ORG e I-ORG Innovación I-ORG SAF2005-25642-E O salary O support O RYC-2008-02631 O for O CD) O and O the O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III I-ORG A107190024 O salary O support O CM04/00028 O and O CES10/021-I3SNS O to O CG O and O AM, O respectively O AM O received O support O from O the O Departament B-ORG d’Universitats I-ORG i I-ORG Recerca I-ORG de I-ORG la I-ORG Generalitat I-ORG de I-ORG Catalunya I-ORG Agencia O de O Gestión O de O Ayudas O Universitarias O y O de O Investigación O AGAUR O grant O 2014SGR263 B-AWARD The O Manhiça O Health O Research O Centre O receives O core O funding O from O the O Spanish O Agency O for O International O Cooperation O and O Development O AECID O ISGlobal O is O a O member O of O the O CERCA O Programme O Generalitat O de O Catalunya O This O work O was O supported O by O the O following O Brazilian O foundations O Fundação O de O Amparo O à O Pesquisa O do O Estado O de O São O Paulo O São O Paulo I-ORG Research I-ORG Foundation—FAPESP O 15/04194-0 O 22/03543-4 O 19/10003-3 O 18/23559-7 O 18/03051-9 O Conselho O Nacional O de O Desenvolvimento O Científico O e O Tecnológico O National O Council I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Development—CNPq I-ORG 431465/2016-9 O Fundo O de O Apoio O ao O Ensino O à O Pesquisa O e O à O Extensão O Education O Research I-ORG and I-ORG Extension I-ORG Support I-ORG Fund—FAEPEX O 2744/19 O and O 2588/20 O and O Coordenação O de O Aperfeiçoamento O de O Pessoal O de O Nível O Superior O Coordination O for I-ORG the I-ORG Improvement I-ORG of I-ORG Higher I-ORG Education—CAPES O F.M O scholarship O 88887.357994/2019-00 O L.V O is O a O fellow O of O CNPq O OS O is O supported O by O Grants O of O the O Deutsche B-ORG Forschungsgemeinschaft I-ORG DFG O SCHI O 871/2 I-AWARD and I-AWARD SCHI I-AWARD 871/5 I-AWARD SCHI I-AWARD 871/6 I-AWARD GR I-AWARD 1748/6 I-AWARD and I-AWARD INST I-AWARD 39/900-1 O and O the O SFB850 O Project O B8 O a O starting O Grant O of O the O European B-ORG Research I-ORG Council I-ORG Programme O “Ideas”—Call O identifier O ERC-2011 B-AWARD StG I-AWARD 282111-ProteaSys O and O the O Excellence B-ORG Initiative I-ORG of I-ORG the I-ORG German I-ORG Federal I-ORG and I-ORG State I-ORG Governments I-ORG EXC O 294 I-AWARD BIOSS O This O research O was O funded O by O the O A*STAR B-ORG Biomedical I-ORG Research I-ORG Council I-ORG National I-ORG Medical I-ORG Research I-ORG Council I-ORG Stratified I-ORG Medicine I-ORG Programme I-ORG Office I-ORG SMPO201302 O awarded O to O Dr. O Puay O Hoon O Tan O and O partially O supported O by O the O SingHealth B-ORG Duke-NUS I-ORG Pathology I-ORG Academic I-ORG Clinical I-ORG Program I-ORG Budding I-ORG Clinician-Scientist I-ORG grant I-ORG ACP O PATH I-AWARD BCS I-AWARD 14 I-AWARD 001 O awarded O to O Dr. O Timothy O Kwang O Yong O Tay O Dr. O Jabed O Iqbal O is O a O recipient O of O the O Transition O Award O from O the O Singapore B-ORG National I-ORG Medical I-ORG Research I-ORG Council I-ORG NMRC/TA/0041/2015 O This O research O was O funded O by O the O MCIN/Spanish B-ORG Research I-ORG Agency I-ORG AEI O 10.13039/501100011033 O grants O PID2019-105995RB-I00 B-AWARD J.J.T.-A O and O J.V O and O PID2019-106410RB-I00 B-AWARD J.L.-B O and O P.O.-S O Moreover O this O research O work O was O also O funded O by O Red B-ORG TerCel I-ORG ISCIII O RD16/0011/0025 B-AWARD J.J.T.-A O Consejería B-ORG de I-ORG Economía I-ORG Conocimiento I-ORG Empresas I-ORG y I-ORG Universidad I-ORG US-1380891 B-AWARD J.J.T.-A O and O J.V O This O study O was O supported O by O NIA B-ORG Grant O U01-AG03365 B-AWARD PI: O Dr. O Albert O NINDS B-ORG Grant O P50NS038377 B-AWARD Dr. O Akhilesh O Pandey O and O Wellcome B-ORG Trust/DBT I-ORG India I-ORG Alliance I-ORG Margdarshi I-ORG Fellowship I-ORG IA/M/15/1/502023 B-AWARD Dr. O Akhilesh O Pandey O The O present O work O is O financially O supported O by O the O Jiangsu B-ORG Province I-ORG Fund I-ORG of I-ORG Sciences I-ORG BK2012240 O Jiangsu B-ORG Fishery I-ORG Project I-ORG D2015–11 O Chinese B-ORG Natural I-ORG Sciences I-ORG Fund I-ORG 31411130191 O 31472296 O Basic B-ORG project I-ORG SB I-ORG Russian I-ORG Academy I-ORG of I-ORG Science I-ORG VI.51.1.3 O and O the O Russian B-ORG Fund I-ORG of I-ORG Basic I-ORG Research O 14–04–91176 O GFEN_a O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 71804201 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2018A0303130046 O 2017A030310346 O and O Sun B-ORG Yat-Sen I-ORG University I-ORG Scientific I-ORG Research I-ORG Foundation I-ORG 17ykpy15 O This O work O was O supported O financially O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31602063 B-AWARD Anhui B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG No.1508085QC60 O Anhui B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Special I-ORG 16030801106 O and O Anhui O Agricultural O University O Talent O Introduction O and O Stable O Project O No. O yj2015-16 O CQ O received O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81573249],http://www.nsfc.gov.cn O CQ O received O Nature B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2016A030313530],http://www.gdstc.gov.cn O JQ O received O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG 2017A020219009],http://www.gdstc.gov.cn O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O We O acknowledge O the O supports O form O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21877021 O 32160661 B-AWARD 32202359 B-AWARD the O Guizhou B-ORG Provincial I-ORG S&T I-ORG Project I-ORG 2018[4007 O the O Guizhou B-ORG Province I-ORG [Qianjiaohe O KY I-AWARD number I-AWARD 2020)004 O Program B-ORG of I-ORG Introducing I-ORG Talents I-ORG of I-ORG Discipline I-ORG to I-ORG Universities I-ORG of I-ORG China I-ORG D20023 O 111 O Program O and O GZU B-ORG Guizhou I-ORG University I-ORG Foundation I-ORG for O Newly O Enrolled O Talent O No. O 202229 B-AWARD This O research O has O been O supported O by O the O Postgraduate B-ORG Research I-ORG and I-ORG Innovation I-ORG Project I-ORG of I-ORG Hunan I-ORG Province I-ORG CX20211118 O the O Project O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG 2021JJ30200 O and O Key B-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG Hunan I-ORG Provincial I-ORG Education I-ORG Department I-ORG 22A0451 O This O work O was O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG for I-ORG Post-doctoral I-ORG Scientists I-ORG of I-ORG China I-ORG grant O no: O 2016M592866 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 31560131 B-AWARD and O 31500309 B-AWARD and O the O Scientific B-ORG Research I-ORG Fund I-ORG for I-ORG Doctors I-ORG of I-ORG Xinjiang I-ORG University I-ORG BS150259 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O a O Medical B-ORG Research I-ORG Council I-ORG and I-ORG Fundação I-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo I-ORG CADDE I-ORG partnership O award O MR/S0195/1 O and O a O John B-ORG Fell I-ORG Research I-ORG Fund I-ORG grant O 005166 B-AWARD N.R.F O is O supported O by O a O Sir B-ORG Henry I-ORG Dale I-ORG Fellowship I-ORG 204311/Z/16/Z O D.D.S.C O is O supported O by O the O Clarendon O Fund O and O by O the O Oxford O University O Zoology O Department O This O research O was O funded O by O the O Special B-ORG Fund I-ORG for I-ORG Agro-scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG of I-ORG Zhejiang I-ORG Province I-ORG LGN18C190011 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG LQ19C010006 O the O National O Natural O Science O Foundation O of O China O 81973233 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2019M652042 O the O Science O Foundation O of O Zhejiang O Sci-Tech O University O 17042058-Y O 17042187-Y B-AWARD the O Project O for O Jiaozhou O Excellent O Innovation O Team O 18-CX-1 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31422032 O 31421004 I-AWARD 91519305 O the O Guangdong B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2014A030308002 O the O Guangdong B-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG 2013B010404040 O the O Guangzhou B-ORG Health I-ORG Care I-ORG Collaborative I-ORG Innovation I-ORG Program I-ORG 201508020250 O and O the O Guangdong B-ORG special I-ORG support I-ORG program I-ORG 2014TQ01R157 O H.Z O received O the O funding O This O work O was O also O partially O supported O by O National B-ORG Science I-ORG Foundation I-ORG of I-ORG United I-ORG States I-ORG III O 1117153 O R.K O received O this O funding O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O authors O are O grateful O for O the O financial O support O of O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 21462018 B-AWARD and O 21861025 B-AWARD the O Science B-ORG Fund I-ORG of I-ORG the I-ORG Technology I-ORG Office I-ORG of I-ORG Jiangxi I-ORG China I-ORG 20192BAB203003 O and O National B-ORG Training I-ORG Programs I-ORG of I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG for I-ORG Undergraduates I-ORG 202211318012 O The O authors O acknowledge O financial O support O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O U1605225 B-AWARD 81971734 I-AWARD 31570974 I-AWARD and I-AWARD 31800794 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG Grant O No. O 2019J01076 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No. O ZQN-713 B-AWARD Funds O for O Foreign O Experts O from O Ministry O of O Science O and O Technology O China O G20190013023 O and O Program O for O Innovative O Research O Team O in O Science O and O Technology O in O Fujian O Province O University O This O work O was O supported O by O The O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81771078 O the B-ORG Project I-ORG of I-ORG Invigorating I-ORG Health I-ORG Care I-ORG through I-ORG Science I-ORG Technology I-ORG and I-ORG Education I-ORG Jiangsu I-ORG Provincial I-ORG Medical I-ORG Innovation I-ORG Team I-ORG CXTDB2017014 O and O Nanjing B-ORG Medical I-ORG Science I-ORG and I-ORG Technique I-ORG Development I-ORG Foundation I-ORG QRX17081 O This O research O was O funded O by O the O Shandong B-ORG Province I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Public O Welfare O Project O 2017GGX20135 B-AWARD Shandong B-ORG Province I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG ZR2016BM17 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21104038 O The O authors O gratefully O acknowledge O these O financial O supports O This O paper O is O supported O by O the B-ORG Humanities I-ORG and I-ORG Social I-ORG Sciences I-ORG Foundation I-ORG for I-ORG the I-ORG Youth I-ORG Scholars I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG 15YJCZH066 O the B-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG of I-ORG Hunan I-ORG Province I-ORG 2016TP1020 O the B-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG of I-ORG Hengyang I-ORG City I-ORG 2017KJ183 O Hunan B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 2018JJ4024 O the B-ORG Scientific I-ORG Research I-ORG Fund I-ORG of I-ORG Hunan I-ORG Provincial I-ORG Education I-ORG Department I-ORG 17A030 O and O the B-ORG 2018 I-ORG National I-ORG Statistical I-ORG Science I-ORG Research I-ORG Project I-ORG of I-ORG China I-ORG 2018LY05 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81373190 O and O 81571587 B-AWARD Science B-ORG Foundation I-ORG of I-ORG Beijing I-ORG 7172178 O CAMS B-ORG Initiative I-ORG for I-ORG Innovative I-ORG Medicine I-ORG 2017-12M-3-001 O and O The B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0901500 O This O work O is O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O Nos O 2017YFE0302400 B-AWARD and I-AWARD 2017YFA0402800 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 11735015 B-AWARD 51871207 I-AWARD 11575229 I-AWARD 51671185 I-AWARD and I-AWARD U1832206 O and O Anhui B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 1908085J17 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81572325 O 81602841 B-AWARD and O 81874058 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20161570 O the O Project B-ORG Funded I-ORG by I-ORG Jiangsu I-ORG Collaborative I-ORG Innovation I-ORG Center I-ORG For I-ORG Cancer I-ORG Personalized I-ORG Medicine I-ORG JX21817902/006 O the O Project O Funded O by O Jiangsu O Postgraduate O Research O and O Innovation O Plan O KYCX18_1491 O and O the O International O Exchange O and O Cooperation O Program O Funded O by O Nanjing O Medical O University O C102 O The O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31472025 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Beijing I-ORG Municipality I-ORG 6162010 O and O the O Beijing B-ORG Key I-ORG Laboratory I-ORG of I-ORG Environmentally I-ORG Friendly I-ORG Pest I-ORG Management I-ORG on I-ORG Northern I-ORG Fruits I-ORG BZ0432 O The O funding O bodies O had O no O role O in O study O design O collection O data O analysis O data O interpretation O or O writing O of O the O manuscript O This O work O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 61527819 O 61875146 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanxi I-ORG Province I-ORG 2015011049 O Shanxi B-ORG Province I-ORG Youth I-ORG Science I-ORG and I-ORG Technology I-ORG Foundation I-ORG 201601D021069 O Shanxi O Scholarship O Council O of O China O SXSCC O 2016-036 O Outstanding O Innovative O Teams O of O Higher O Learning O Institutions O of O Shanxi O Program O for O Sanjin O Scholar O This O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31871979 O 31901881 B-AWARD National B-ORG Key I-ORG R&D I-ORG Plan I-ORG in I-ORG China I-ORG 2017YFD0201701 O 2016YFD0300701 B-AWARD and O the O Cooperation B-ORG Project I-ORG between I-ORG Belgium I-ORG and I-ORG China I-ORG from I-ORG MOST I-ORG 2014DF32270 O The O funding O organizations O played O no O role O in O the O design O of O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG No. O CAAS-ASTIP-IVFCAAS B-AWARD China B-ORG Agriculture I-ORG Research I-ORG Systems I-ORG No. O CARS-25-C-13 B-AWARD the B-ORG special I-ORG fund I-ORG for I-ORG agro-scientific I-ORG research I-ORG in I-ORG the I-ORG public I-ORG interest I-ORG of I-ORG China I-ORG No. O 201303014 B-AWARD and O the B-ORG special I-ORG fund I-ORG for I-ORG agricultural I-ORG research I-ORG outstanding I-ORG talents I-ORG and I-ORG innovation I-ORG team O Ministry O of O agriculture O P. O R. O China O 2016 O The O funding O bodies O had O no O role O in O the O design O collection O and O analysis O interpretation O of O data O or O in O writing O the O manuscript O This O research O was O funded O by O FAPESP B-ORG Grant O 2013/07914-8 B-AWARD and O USP B-ORG for O providing O scholarships O for O visiting O professors O 2016.1.920.93 O IP O and O MLC O were O supported O in O part O by O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Higher I-ORG Education I-ORG of I-ORG the I-ORG Russian I-ORG Federation I-ORG Project O Number O 075-15-2019-1880 B-AWARD This O work O was O supported O by O the O DOLORisk O project O EU O Horizon2020 O grant O number O 633491 B-AWARD the O STRADL O project O Wellcome O Trust O grant O number O 104036/Z/14/Z B-AWARD and O theCentre O for I-ORG Cognitive I-ORG Ageing I-ORG and I-ORG Cognitive I-ORG Epidemiology[Medical O Research O Council O and O Biotechnology O and O Biological O Sciences O Research O Council O grant O number O MR/K026992/1 B-AWARD We O are O grateful O for O support O from O the O Dr. O Mortimer O And O Theresa O Sackler O Foundation O The O funders O had O no O role O in O study O design O data O collection O data O analysis O interpretation O writing O of O the O report O This O study O was O funded O by O the O Institute B-ORG for I-ORG Basic I-ORG Science I-ORG Grant O no. O IBS-R015-D1 B-AWARD the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG Grant O no. O NRF-2016R1A2B4008545 B-AWARD and O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG ICT I-ORG of I-ORG Korea I-ORG under O the O ITRC O Program O Grant O no. O IITP-2018-0-01798 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O a O Natural B-ORG Environment I-ORG Research I-ORG Council I-ORG UK) I-ORG GW4 O DTP O studentship O Grant O No. O NE/L002434/1 B-AWARD Natural B-ORG England I-ORG Ref O PO B-AWARD 904130 O and O the O University O of O Exeter O Rita O Castilho O was O funded O by O FCT—Foundation B-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG through O project O UID/Multi/04326/2013 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O a O fellowship O A.B O from O the O Fondation B-ORG ARC I-ORG pour I-ORG la I-ORG Recherche I-ORG sur I-ORG le I-ORG Cancer I-ORG SAE20111204362 O The O UKCCS O is O supported O by O Blood B-ORG Cancer I-ORG UK I-ORG grant O number O 15037 B-AWARD and O Cancer B-ORG Research I-ORG UK I-ORG grant O number O 29685 B-AWARD S.S.K O was O supported O by O NERC B-ORG Advanced I-ORG Fellowship I-ORG NE/J019100/1 B-AWARD and O European B-ORG Research I-ORG Council I-ORG Starting I-ORG Grant I-ORG 640004 B-AWARD J.J.H.N O was O supported O by O an O Aides B-ORG à I-ORG la I-ORG Formation I-ORG Recherche I-ORG doctoral I-ORG grant I-ORG from I-ORG the I-ORG Fonds I-ORG National I-ORG de I-ORG la I-ORG Recherche I-ORG Luxembourg I-ORG 4005263 O The O author(s O disclosed O receipt O of O the O following O financial O support O for O the O research O authorship O and/or O publication O of O this O article O We O acknowledge O the O support O of O the O Economic B-ORG and I-ORG Social I-ORG Research I-ORG Council I-ORG Case O studentship I-AWARD ES/J500094/1 I-AWARD and O grant O RES-062-23-274 B-AWARD now O ES/I00064X/1 O the O Nuffield B-ORG Foundation I-ORG EDU-8366 O and O EDU-32083 B-AWARD and O the O Wellcome B-ORG Trust I-ORG 060774 O For O G. O Conti-Ramsden O this O research O was O also O supported O by O the O NIHR O Manchester O Biomedical O Research O Centre O There O was O no O involvement O of O the O funders O in O study O design O data O collection O data O analysis O manuscript O preparation O or O journal O submission O decisions O This O work O was O supported O by O the O Thailand B-ORG Research I-ORG Fund I-ORG DBG6180001 O and O by O the O Russian B-ORG Foundation I-ORG for I-ORG Basic I-ORG Research I-ORG Grant O No. O RFBR B-AWARD 15-29-02771 O fieldwork O specimen O examination O Molecular O experiments O phylogenetic O analyses O specimen O storage O examination O and O microCT-analysis O were O carried O out O with O the O financial O support O of O Russian B-ORG Science I-ORG Foundation I-ORG RSF O grant O No. O 14-50-00029 B-AWARD The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China(No.81870193 O Jiangsu B-ORG Provincial I-ORG Special I-ORG Program I-ORG of I-ORG Medical I-ORG Science(BE2017610 O The O Young B-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81700415 O The O Project O of O Invigorating O Health O Care O through O Science O Technology O and O Education--Jiangsu O Provincial I-ORG Medical I-ORG Youth I-ORG Talent I-ORG Financial O support O was O provided O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO.U1304216 O the O Research B-ORG Fund I-ORG of I-ORG Yong I-ORG Scholars I-ORG for I-ORG the I-ORG Doctoral I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG of I-ORG China I-ORG Grant O No. O 20124101120015 B-AWARD and O the O Foundation B-ORG of I-ORG He’nan I-ORG Educational I-ORG Committee I-ORG Grant O No. O 13A610689 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O National B-ORG Institute I-ORG on I-ORG Drug I-ORG Abuse(1R21DA039458),National O Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases(5R01AI132030),National O Institute I-ORG of I-ORG Mental I-ORG Health(5R01MH106415 O andNational O Center I-ORG for I-ORG Complementary I-ORG and I-ORG Integrative I-ORG Health(1R61AT010606 O The O funders O played O no O role O in O the O study O planning O analysis O or O outcomes O The O present O work O was O performed O in O the O context O of O the O Inspire O Program O a O research O platform O supported O by O grants O from O the O Region B-ORG Occitanie/Pyrénées-Méditerranée I-ORG Reference O number O 1901175 B-AWARD and O the O European B-ORG Regional I-ORG Development I-ORG Fund I-ORG ERDF O Project O number O MP0022856 B-AWARD and O received O additional O funds O from O Alzheimer B-ORG Prevention I-ORG in I-ORG Occitania I-ORG and I-ORG Catalonia I-ORG APOC O Chair I-AWARD of I-AWARD Excellence I-AWARD I-AWARD Inspire I-AWARD Program O Academia B-ORG Sinica I-ORG and O Ministry B-ORG of I-ORG Science I-ORG and O Technology B-ORG of I-ORG Taiwan I-ORG supported O our O work O MOST O 107-0210-01-19-01 O 108-2321-B-001-010 B-AWARD and O 104-2320-B-001-009-MY3 B-AWARD CRC O grants O of O IBMS O IBMS-CRC108-P02 O and O AS O investigator O award O AS-IA-109-L03 O This O study O was O partially O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O 61803121 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG under O Grant O 2019M651277 B-AWARD ROOTCLOUD O Experiment O Test O and O Validation O Environment O of O Industrial O Internet O Platform O Supported O by O 2018 O Innovation O and O Development O Project O of O Industrial O Internet O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No. O HIT B-AWARD NSREF I-AWARD 2020011 O The O authors O would O like O to O thank O all O the O reviewers O and O the O editor O for O their O valuable O comments O This O research O was O funded O by O the B-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG CAAS-ASTIP-2014-LIHPS-01 O the B-ORG National I-ORG Beef I-ORG Cattle I-ORG Industry I-ORG Technology I-ORG I-ORG System I-ORG CARS-37 O and O the B-ORG Special I-ORG fund I-ORG for I-ORG basic I-ORG scientific I-ORG research I-ORG business I-ORG of I-ORG central I-ORG public I-ORG research I-ORG institutes I-ORG 1610322017002 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 81201857 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Nantong I-ORG City I-ORG grant O no. O MS12016012 B-AWARD Nantong B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG grant O no. O MS22015055 B-AWARD Funding O from O National O Natural O Science O Foundation O of O China O grant O no. O 81201857 O was O used O for O study O design O and O preliminary O literature O investigation O Technology O Project O of O Nantong O City O grant O no. O MS12016012 O was O used O for O laboratory O and O researcher O expenses O Nantong O Science O and O Technology O Program O grant O no. O MS22015055 O was O used O for O data O analysis O interpretation O and O manuscript O writing O This O work O was O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31800003 B-AWARD LYY O http://www.nsfc.gov.cn O the B-ORG GDAS I-ORG Special I-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG 2020GDASYL-20200103032 B-AWARD WCL O http://www.gdas.gd.cn O the O Guangdong B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Strategy I-ORG Special I-ORG Fund I-ORG 2018B020205003 B-AWARD FGD O http://gdstc.gd.gov.cn/tzgg O the B-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG of I-ORG Guangdong I-ORG 2019B030316009 B-AWARD LAZ O http://pro.gdstc.gd.gov.cn/egrantweb O and O the B-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG of I-ORG Guangzhou I-ORG 201704020088 B-AWARD LAZ O http://sop.gzsi.gov.cn O This O work O was O supported O by O a O Doctoral O Training O Grant O to O M.J.W O provided O jointly O by O the O UK O MRC B-ORG MR/K501335/1 O and O UK O BBSRC B-ORG BB/J013854/1 O the O Wellcome B-ORG Trust I-ORG 202789/Z/16/Z O Medical B-ORG Research I-ORG Scotland I-ORG MRS O G.M O and O MS O society O of O Great O Britain O 56 O This O study O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0501304 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31772730 O 31972700 B-AWARD the O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG 973 I-ORG program I-ORG of I-ORG China I-ORG Grant O 2015CB150300 B-AWARD and O the O Beijing B-ORG Municipal I-ORG Natural I-ORG Science I-ORG Foundation I-ORG 6172023 O This O study O was O funded O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81704114 B-AWARD and O 81602272 B-AWARD the O Postdoctoral B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 2018M640315 B-AWARD the O Project B-ORG of I-ORG Excellent I-ORG Innovation I-ORG Talents I-ORG by I-ORG Heilongjiang I-ORG University I-ORG of I-ORG Chinese I-ORG Medicine I-ORG No. O 2018RCD26 B-AWARD and O the O Postdoctoral B-ORG Funding I-ORG Project I-ORG of I-ORG Heilongjiang I-ORG Provincial I-ORG Government I-ORG No. O LBH-Z18272 B-AWARD This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81572726 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2018A030313641 B-AWARD and O No. O 2016A030313848 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2014A020212122 B-AWARD and O No. O 2016A020212004 B-AWARD and O the O Medical B-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O A2016312 B-AWARD The O research O has O been O funded O by O projects O MARSYMBIOMICS B-ORG project I-ORG Spanish I-ORG MINECO O CTM2013-43287-P B-AWARD BluePharmTrain B-ORG FP7 I-ORG People-INT O Ref B-AWARD 2013-667786 O Grup B-ORG Consolidat O SGR-120 B-AWARD Benthomics O Spanish B-ORG MICINN O CTM-2010-22218-C02-01 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31802348 O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG 2016A020210023 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG 2015A030313699 O and O the O Modern B-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG grant O number O CARS-45-21 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation O Grant O Number O 2018M643130 B-AWARD Medical B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG China O Grant O Number O A2019538 B-AWARD Guangdong B-ORG gastrointestinal I-ORG disease I-ORG research I-ORG center O Grant O Number O 2017B020209003 B-AWARD the B-ORG Special I-ORG Scientific I-ORG Research I-ORG Fund I-ORG of I-ORG Public I-ORG Welfare I-ORG Profession I-ORG of I-ORG National I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission O Grant O Number O 201502026 B-AWARD We O are O grateful O for O support O from O a O number O of O EPSRC B-ORG research O grants O EP/G065802/1 B-AWARD The B-ORG Digital I-ORG Economy I-ORG HORIZON I-ORG Hub O EP/I017321/1 B-AWARD MOLTEN O Mathematics B-ORG Of I-ORG Large I-ORG Technological I-ORG Evolving I-ORG Networks O EP/F033036/1 B-AWARD Cognitive B-ORG Systems I-ORG Science I-ORG Bridging O the O Gaps O EP/I016856/1 B-AWARD NeuroCloud B-ORG and O EP/H024883/1 B-AWARD Towards O an O integrated O neural O field O computational O model O of O the O brain O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 81572481 B-AWARD to O YP O the B-ORG key I-ORG project I-ORG of I-ORG production I-ORG study I-ORG and I-ORG research I-ORG of I-ORG Guangzhou I-ORG city I-ORG No. O 201508020058 B-AWARD to O YP O the B-ORG International I-ORG Collaboration I-ORG Program I-ORG of I-ORG Universities I-ORG in I-ORG Guangdong I-ORG Province I-ORG Grant I-ORG No.2012 O gjhz001 I-AWARD to O Y.P O the B-ORG Science I-ORG I-ORG Technique I-ORG Plan I-ORG fund I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2009B060700040 O to O YP O the B-ORG Sun I-ORG Yat-Sen I-ORG Scientific I-ORG Research I-ORG Sailing I-ORG Project I-ORG YXQH201702 O to O J.Pan O the B-ORG Guangdong I-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2017A030313655 O to O J. O Pan O and O the B-ORG Science I-ORG Technique I-ORG Plan I-ORG fund I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2013B021800098 O to O M.Li O KK: O the B-ORG Japan I-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG KAKENHI I-ORG Grant O Number O 16K13031,https://www.jsps.go.jp/j-grantsinaid/KK:Health B-AWARD Science I-ORG Center I-ORG Foundation O Grant O Number O 2018-1,http://hscsagami.or.jp/zaidan.htmlKK:Qdai-jump B-AWARD Research I-ORG Program I-ORG Grant O Number O 28314,https://www.kyushu-u.ac.jp/ja/research/support/other B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O article O presents O independent O research O funded O by O the O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG NIHR O under O the O Programme O Grants O for O Applied O Research O programme O Grant O Reference O Number O RP-PG-0608-10079 B-AWARD The O views O expressed O in O this O publication O are O those O of O the O author(s O and O not O necessarily O those O of O the O NIHR O or O the O Department O of O Health O and O Social O Care O The O funder O had O no O role O in O study O design O data O collection O data O analysis O data O interpretation O the O writing O of O the O manuscript O and O decision O to O submit O the O manuscript O for O publication O The O researchers O and O funders O were O independent O The O VBI O team O acknowledges O the O support O of O the O National O Institute O for O Health O Research O Clinical O Research O Network O NIHR O CRN O The O work O of O KW O and O SB O was O funded O by O the O UK B-ORG Medical I-ORG Research I-ORG Council I-ORG MC_UU_12015/3 O and O the O NIHR B-ORG Biomedical I-ORG Research I-ORG Centre I-ORG Cambridge I-ORG IS-BRC-1215-20014 O SJG O is O NIHR O Senior O Investigator O The O University O of O Cambridge O has O received O salary O support O in O respect O of O SJG O from O the O NHS O in O the O East O of O England O through O the O Clinical O Academic O Reserve O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH O P30GM124165 O S10RR029205 B-AWARD S10OD021527 B-AWARD P41GM111244 B-AWARD R01GM112940 B-AWARD to O A.S O U.S O Department O of O Energy O DOE O Office O of O Science O User O Facility O operated O for O the O DOE O Office O of O Science O by O Argonne B-ORG National I-ORG Laboratory I-ORG DE-AC02-06CH11357 O DOE O Office O of O Biological B-ORG and I-ORG Environmental I-ORG Research I-ORG KP1605010 O DOE O Office B-ORG of I-ORG Science I-ORG and I-ORG Office I-ORG of I-ORG Basic I-ORG Energy I-ORG Sciences I-ORG Program I-ORG DE-SC0012704 O in O part O Funding O for O open O access O charge O NIH O Grant O R01GM112940 O GJF O is O supported O by O the O National B-ORG Institute I-ORG on I-ORG Aging I-ORG K76AG59992 O the O National B-ORG Institute I-ORG of I-ORG Neurological I-ORG Disorders I-ORG and I-ORG Stroke I-ORG R03NS112859 O the O American B-ORG Heart I-ORG Association I-ORG 18IDDG34280056 O a O Yale O Pepper O Scholar O Award O P30AG021342 O and O the O Neurocritical O Care O Society O Research O Fellowship O The O study O was O supported O by O a O grant O from O theStroke O Association[R1425201 O and O a O grant O from O theEuropean O Research I-ORG Council[FLEXSEM O – I-AWARD 771863 O awarded O to O E.J O This O work O was O part-funded O by O the O Wellcome O Trust O ref O 204829 B-AWARD through O theCentre O for I-ORG Future I-ORG Health I-ORG CFH I-ORG at I-ORG the I-ORG University I-ORG of I-ORG York I-ORG This O study O was O supported O by O the O Natural B-ORG Science I-ORG Fund I-ORG 31971644 O 31901365 B-AWARD 31500523 B-AWARD the O Fund B-ORG for I-ORG Introduced I-ORG Talents I-ORG for I-ORG Shanxi I-ORG Agricultural I-ORG University I-ORG 2014YJ19 O and O the O Research B-ORG Projects I-ORG of I-ORG Shanxi I-ORG Excellent I-ORG Doctors’ I-ORG Work I-ORG Award I-ORG Fund I-ORG SXYBKY2018032 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O T.Y O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0801602 O Basic B-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2013CB227902 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51574060 O W.S O was O supported O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG N150106002 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grants O 81370065 O 81372653 B-AWARD a O basic O research O project O of O the O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG 15JC1401200 O and O The O National B-ORG Science I-ORG Fund I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG 81625016 O This O study O was O supported O by O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Henan I-ORG Province I-ORG no. O 222300420458 B-AWARD Scientific B-ORG Studio I-ORG of I-ORG Zhongyuan I-ORG Scholars I-ORG no. O 30601985 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Henan I-ORG Province I-ORG Youth I-ORG Project I-ORG no. O 202300410203 B-AWARD Zhongyuan B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Leading I-ORG Scientist I-ORG Project I-ORG 214200510003 O and O Program B-ORG for I-ORG Innovative I-ORG Research I-ORG Team I-ORG in I-ORG Science I-ORG and I-ORG Technology I-ORG in I-ORG University I-ORG of I-ORG Henan I-ORG Province I-ORG 21IRTSTHN022 O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O Number O 2017YFB1300300 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Numbers O 81630051 B-AWARD 91520205 B-AWARD 61603269 B-AWARD 81601565 B-AWARD 81571762 B-AWARD and O 31500865 B-AWARD and O Tianjin B-ORG Key I-ORG Technology I-ORG R&D I-ORG Program I-ORG Grant O Number O 15ZCZDSY00930 B-AWARD This O work O was O supported O by O the O Engineering B-ORG Technology-based I-ORG Innovation I-ORG in I-ORG Medicine I-ORG eTIME I-ORG consortium I-ORG grant I-ORG eTIME318943 O the O EU B-ORG FP7 I-ORG International I-ORG Research I-ORG Staff I-ORG Exchange I-ORG Scheme I-ORG IRSES I-ORG grant I-ORG #PIRSES-GA-2012-318943 O and O the O University B-ORG of I-ORG Canterbury I-ORG Canterbury O Scholarship’ O grant O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 60907003 O 61805278 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M633704 O the O Foundation O of O NUDT O JC13-02-13 O ZK17-03-01 O the O Hunan O Provincial O Natural O Science O Foundation O of O China O 13JJ3001 O 2020JJ5646 O the O Program B-ORG for I-ORG New I-ORG Century I-ORG Excellent I-ORG Talents I-ORG in I-ORG University I-ORG NCET-12-0142 O the O National O Natural O Science O Foundation O of O China O 61661004 O and O Guangxi B-ORG Science I-ORG Foundation I-ORG 2017GXNSFAA198227 O This O research O was O funded O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0501901 O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 6164041 O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG ASTIP-IAS02 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31872337 O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51675242 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20180875 O BK20180873 B-AWARD Chinese B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M640461 O and O Senior B-ORG Talent I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG University I-ORG 18JDG011 O This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2018YFA0703700 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 51971025 I-AWARD and I-AWARD 51901012 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG FRF-TP-17-073A1 O and O 111 B-ORG Project I-ORG No. O B170003 O This O work O was O supported O by O grants O PI15/00752 B-AWARD and O PI15/01118 B-AWARD from O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III I-ORG ISCIII)-Fondo O Europeo O de O Desarrollo O Regional O FEDER)-Ministerio O de O Economía O y O Competitividad O MINECO)-AES O grant O PI18/00643 B-AWARD from O ISCIII-FEDER O Ministerio B-ORG de I-ORG Ciencia I-ORG Innovación I-ORG y I-ORG Universidades I-ORG MICINN)-AES O and O grant O RTI2018-095159-B-I00 B-AWARD from O MICINN O L.M.P O is O supported O by O a O predoctoral O contract O PEJD-2018-PRE/BMD-7965 O from O the O Comunidad B-ORG de I-ORG Madrid I-ORG CAM O L.S O is O supported O by O a O Miguel O Servet O contract O CPII16/00038 O from O ISCIII O FEDER-MINECO-AES O FSE O N.V O is O supported O by O Program B-AWARD I2 I-AWARD from O CAM O The O research O is O supported O by O the O Russian B-ORG Foundation I-ORG for I-ORG Basic I-ORG Research I-ORG project O No. O 21-51-53014 B-AWARD the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Higher I-ORG Education I-ORG of I-ORG the I-ORG Russian I-ORG Federation I-ORG Project O No. O FZEN-2020-0017 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Projects O Nos O 11872220 B-AWARD 12111530006 B-AWARD This O research O was O funded O by O the B-ORG Amazon I-ORG Foundation I-ORG for I-ORG Research I-ORG Support I-ORG FAPESPA O grant O number O 006/2020 O the B-ORG Secretary I-ORG of I-ORG Science I-ORG Technology I-ORG and I-ORG Higher I-ORG Professional I-ORG and I-ORG Technological I-ORG Education I-ORG SECTET O grant O number O 09/2021 O the B-ORG Coordenação I-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior—Brazil I-ORG CAPES O grant O number O ‘Notice O n° O 13/2020’ B-AWARD and O the B-ORG Conselho I-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico—Brazil O grant O number O ‘INCT O 406360/2022-7’ B-AWARD This O work O was O funded O by O the O Ministry B-ORG of I-ORG Education I-ORG University I-ORG and I-ORG Research I-ORG MIUR O to O T.P O and O C.F O Euro-BioImaging–Roadmap/ESFRI B-AWARD from O European B-ORG Commission I-ORG to O T.P O Fondazione O Cassa O di O Risparmio O di O Padova O e O Rovigo O CARIPARO O Foundation O Excellence O project O 2017 O 2018/113 O to O T.P O UniPD B-ORG Project O 2015 O CPDA157003 O PRIN-2015W2N883_001 B-AWARD and O PRIN-20175C22WM B-AWARD to O C.F O UniPD O funds B-AWARD for I-AWARD research I-AWARD equipment-2015 O ES O was O supported O by O a O CARIPARO O Ph.D O fellowship O 2016–2019 O As O post-docs O E.S O was O supported O by O PRIN-20175C22WM O and O A.L O by O UniPD O CPDA157003 O and O BIRD O 2017 O grants O to O C.F O This O study O was O supported O in O part O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Program I-ORG 81871751 O 81672126 B-AWARD the O Program B-ORG of I-ORG Second I-ORG Military I-ORG Medical I-ORG University I-ORG 2017QN04 O and O the O Ningbo B-ORG Natural I-ORG Science I-ORG Fund I-ORG 2018A610257 O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O financially O supported O by O the B-ORG Key I-ORG Projects I-ORG of I-ORG Joint I-ORG Funds I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG and I-ORG Xinjiang I-ORG Uygur I-ORG Autonomous I-ORG Region I-ORG of I-ORG China I-ORG No. O U1130303 B-AWARD the B-ORG Technology I-ORG Cooperation I-ORG Projects I-ORG of I-ORG Science I-ORG in I-ORG Shanghai I-ORG China I-ORG No. O 14495800200 B-AWARD and O the B-ORG Science I-ORG I-ORG Technology I-ORG Constructing I-ORG Project I-ORG Mandatory I-ORG of I-ORG Xinjiang I-ORG Uygur I-ORG Autonomous I-ORG Region I-ORG of I-ORG China I-ORG No. O 2013911134 B-AWARD This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81273064 O 81773421 B-AWARD the O Innovation B-ORG Team I-ORG of I-ORG Jiangsu I-ORG Health I-ORG CXTDA2017035 O and O Jiangsu B-ORG Province I-ORG Social I-ORG Development I-ORG Research I-ORG BE2015607 O This O research O was O funded O by O research O grants O from O Nutricia B-ORG Danone I-ORG Advanced I-ORG Medical I-ORG Nutrition I-ORG grant O number O HESDY B-AWARD Grant O Fundació O Salut O Del O Csdm O Strategic O Action O Grant O in O Oropharyngeal O Dysphagia O provided O by O the O Centro B-ORG de I-ORG Investigación I-ORG Biomédica I-ORG en I-ORG Red I-ORG en I-ORG El I-ORG Área I-ORG de I-ORG Enfermedades I-ORG Hepáticas I-ORG Y I-ORG Digestivas I-ORG CIBERehd I-ORG Instituto I-ORG de I-ORG Salud I-ORG Carlos I-ORG III O Fondo O de O Investigaciones O Sanitarias O Instituto O de O Salud O Carlos O III O grant O number O PI22/01101 B-AWARD and O Proyectos B-ORG de I-ORG Investigación I-ORG Clínica I-ORG Independiente I-ORG Instituto I-ORG de I-ORG Salud I-ORG Carlos I-ORG III I-ORG grant O number O ICI20/00117 B-AWARD This O work O was O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jilin I-ORG Province I-ORG Grant O Nos O YDZJ202201ZYTS643 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 82003173 B-AWARD and O Department B-ORG of I-ORG Finance I-ORG of I-ORG Jilin I-ORG Province I-ORG Grant O Nos O 2020SLZ46 B-AWARD This O work O was O supported O by O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 62161009 B-AWARD and O 62261010 B-AWARD the O Projects B-ORG of I-ORG Talents I-ORG Recruitment I-ORG of I-ORG GDUPT I-ORG RC-XJ2022000401 O the O Open B-ORG Fund I-ORG of I-ORG Guangxi I-ORG Key I-ORG Laboratory I-ORG of I-ORG Information I-ORG Materials I-ORG No. O 211022-K B-AWARD and O the O China B-ORG Sponsorship I-ORG Council I-ORG No. O 201708430104 B-AWARD This O work O was O supported O by O grants O from O the B-ORG National I-ORG Important I-ORG Science I-ORG I-ORG Technology I-ORG Specific I-ORG Project I-ORG 2014ZX08011-003 O to O Yong-Hua O Yang O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31372140 O to O Yong-Hua O Yang O Program B-ORG for I-ORG Changjiang I-ORG Scholars I-ORG and I-ORG Innovative I-ORG Research I-ORG Team I-ORG in I-ORG University I-ORG from I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG IRT_14R27 O to O Yong-Hua O Yang O and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 020814380002 O to O Yong-Hua O Yang O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by B-ORG the I-ORG National I-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF I-ORG grant I-ORG funded I-ORG by I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG ICT I-ORG and I-ORG Future I-ORG Planning I-ORG of I-ORG Korea I-ORG grant O number O 2016R1C1B2010739 B-AWARD to O JYP O the B-ORG Korea I-ORG Health I-ORG Technology I-ORG R&D I-ORG Project I-ORG grant I-ORG through I-ORG the I-ORG Korea I-ORG Health I-ORG Industry I-ORG Development I-ORG Institute I-ORG KHIDI I-ORG funded I-ORG by I-ORG the I-ORG Ministry I-ORG of I-ORG Health I-ORG I-ORG Welfare I-ORG Republic I-ORG of I-ORG Korea I-ORG grant O number O HI17C1934 B-AWARD to O COK O the B-ORG Korean I-ORG Mental I-ORG Health I-ORG Technology I-ORG R&D I-ORG Project I-ORG Ministry I-ORG of I-ORG Health I-ORG I-ORG Welfare O Republic O of O Korea O grant O number O HM15C0995 B-AWARD to O JYP O and O a O “Woo B-ORG Young I-ORG ryoul” I-ORG research I-ORG grant I-ORG of I-ORG Yonsei I-ORG University I-ORG College I-ORG of I-ORG Medicine I-ORG for O grant O number O 6-2015-0174 B-AWARD to O JYP O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Projects B-ORG of I-ORG Medical I-ORG and I-ORG Health I-ORG Technology I-ORG Development I-ORG Program I-ORG in I-ORG Zhejiang I-ORG Province O grant O number O 2018KY538 B-AWARD the O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O LY18H120008 B-AWARD and O the O Wenzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Bureau O grant O number O Y20190646 B-AWARD This O work O was O supported O in O part O by O grants O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG No. O 2021YFD1600400 B-AWARD the O General B-ORG Plan I-ORG of I-ORG Shaanxi I-ORG Province I-ORG No. O 2020GY-236 B-AWARD 2022NY-035 B-AWARD the O Key B-ORG Industrial I-ORG Chain I-ORG Projects I-ORG of I-ORG the I-ORG Shaanxi I-ORG Province-Agricultural I-ORG Field I-ORG 2021ZDLNY04-01 O 2022ZDLNY04-05 B-AWARD Industrialization B-ORG projects I-ORG of I-ORG the I-ORG Education I-ORG Department I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 22JC021 O the O Project B-ORG from I-ORG Weiyang I-ORG Technology I-ORG Bureau I-ORG 202131 O the O Project B-ORG from I-ORG the I-ORG Xi’an I-ORG City I-ORG Innovation I-ORG Plan-Agricultural I-ORG Field I-ORG 21NYYF0022 O the O project B-ORG from I-ORG Qinchuang I-ORG Yuan I-ORG “Scientist I-ORG Engineers” I-ORG Team I-ORG S2022-ZC-QCYK-0011 O and O the O Project B-ORG from I-ORG the I-ORG Ningxia I-ORG Zhong I-ORG Ning I-ORG Goji I-ORG Industry I-ORG Innovation I-ORG Research I-ORG Institute I-ORG ZNGQCX-A-2020003 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 42101415 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2020M681545 O Ministry B-ORG of I-ORG Education I-ORG of I-ORG Humanities I-ORG and I-ORG Social I-ORG Science I-ORG Project I-ORG 21YJCZH181 O and O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2022YFC3800804-01 O This O work O was O supported O and O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0800701 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 81571341 I-AWARD 81371500 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG 2019JJ40424 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O research O leading O to O these O results O was O supported O by O MICINN B-ORG by O supporting O the O Ramón O y O Cajal O grant O for O M.A O Prieto O RYC-2017-22891 O and O by O Xunta B-ORG de I-ORG Galicia I-ORG by O supporting O the O program O EXCELENCIA-ED431F O 2020/12 O and O the O post-doctoral O grant O L. O Cassani O ED481B-2021/152 O This O work O has O also O received O funding O from O the O Argentinean B-ORG Agency I-ORG for I-ORG the I-ORG Scientific I-ORG and I-ORG Technological I-ORG Promotion I-ORG ANPCyT O Argentina O under O the O project O PICT B-AWARD 2020)/1602 I-AWARD This O study O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O No. B-AWARD 61702228 I-AWARD 61803183 I-AWARD 61304264 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province O No. B-AWARD BK20170198 I-AWARD BK20180591 O Jiangsu B-ORG Planned I-ORG Projects I-ORG for I-ORG Postdoctoral I-ORG Research I-ORG Funds O No.1601012A B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities O No. B-AWARD JUSRP1805XNC I-AWARD and I-AWARD the I-AWARD 111 I-AWARD Project I-AWARD B12018 O Thanks O to O Wenling O Langgao O pension O Home O for O providing O the O testing O site O This O work O was O funded O by O Hi-Tech B-ORG Research I-ORG and I-ORG Development I-ORG 863 I-ORG Program I-ORG of I-ORG China I-ORG Grant I-ORG No. O 2013AA102507 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31472153 I-AWARD No. I-AWARD 30901053 I-AWARD and I-AWARD No. I-AWARD 31372379 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG in I-ORG China I-ORG No. O XDJK2013A001 O and O Chongqing B-ORG Youth I-ORG Science I-ORG and I-ORG Technology I-ORG Talent I-ORG Training I-ORG Project I-ORG cstc2014kjrc-qnrc80001 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O PhD B-ORG Start-up I-ORG Fund I-ORG of I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG 2015A030310435 O and O the O Medical B-ORG Science I-ORG and I-ORG Technology I-ORG Foundation I-ORG of I-ORG Guangzhou I-ORG City I-ORG 20151A011072 O and O the O Science B-ORG Foundation I-ORG of I-ORG Guangzhou I-ORG Medical I-ORG University I-ORG 2014C20 O This O work O was O partly O supported O by O a O grant O from O the B-ORG Ministry I-ORG of I-ORG Education I-ORG Culture I-ORG Science I-ORG and I-ORG Technology I-ORG Japan I-ORG to O SM O and O from O the B-ORG Japan I-ORG Agency I-ORG of I-ORG Medical I-ORG Research I-ORG and I-ORG Development I-ORG 17km0405202h0802 O TK, O TY, O SM O The O research O leading O to O these O results O has O received O funding O from O the O European B-ORG Union's I-ORG Seventh I-ORG Framework I-ORG Programme I-ORG FP7/2007-2013 O for O the O Innovative O Medicine O Initiative O under O grant O agreement O n° O 115006 O the O SUMMIT O Consortium O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81760776 B-AWARD National O Natural O Science O Foundation O of O China O No. O 81874336 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Inner I-ORG Mongolia I-ORG No. O 2018ZD13 B-AWARD Agriculture B-ORG Research I-ORG System I-ORG of I-ORG China I-ORG No.CARS-21 O 2018 O Chinese O medicine O public O health O service O subsidy O special O “the O fourth O survey O on O Chinese O materia O medica O resource” O No. O Finance O Society O 2018 O 43 O This O research O project O was O supported O by O Key B-ORG project I-ORG of I-ORG Ningxia I-ORG Natural I-ORG Science I-ORG Foundation I-ORG NZ15130 O for O YB, O and O The B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81502694 O and O Postdoctoral B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 2015M570330 O for O Q-AJ O YB O was O in O charge O of O study O design O data O collection O and O analysis O and O preparation O of O the O manuscript O Q-AJ O was O in O charge O of O preparation O of O the O manuscript O This O study O was O funded O by O grants O from O the O Natural B-ORG Science I-ORG Youth I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2022QC028 O and O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG 2019JZZY010719 O and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2019YFA0904003 O and O Linyi B-ORG City I-ORG Agricultural I-ORG and I-ORG Animal I-ORG Husbandry I-ORG Waste I-ORG Recycling I-ORG and I-ORG Public I-ORG Health I-ORG Improvement I-ORG Project I-ORG CXGC2022A27 O This O article O was O supported O by O grants O from O the O Shanghai B-ORG Municipal I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Research I-ORG Center I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG Schools I-ORG heritage I-ORG project I-ORG funding I-ORG project O number O ZY3-CCCX-1-1007 B-AWARD Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Committee I-ORG key I-ORG research I-ORG project I-ORG funding I-ORG project O number O 16401970300 B-AWARD and O Shanghai B-ORG Municipal I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG project I-ORG funding I-ORG project O number O 2014LQ021A B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 81872169 B-AWARD 81702629 B-AWARD the O Tianjin B-ORG key I-ORG research I-ORG and I-ORG development I-ORG program I-ORG science I-ORG and I-ORG technology I-ORG support I-ORG key I-ORG projects I-ORG Grant O No. O 17YFZCSY00690 B-AWARD and O the O Tianjin B-ORG Municipal I-ORG Science I-ORG and I-ORG technology I-ORG project I-ORG Grant O No. O 19JCYBJC27400 B-AWARD There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O Cancer B-ORG Prevention I-ORG I-ORG Research I-ORG Institute I-ORG of I-ORG Texas I-ORG RR150076 O the O Welch B-ORG Foundation I-ORG 1-1923-20170325 O the O Lupe O Murchison O Foundation O and O Ted B-ORG Nash I-ORG Long I-ORG Life I-ORG Foundation I-ORG to O K.K.F O NIH O GM025874 O TO O S.L O Evelyne O Mercure O Economic B-ORG and I-ORG Social I-ORG Research I-ORG Council I-ORG https://dx.doi.org/10.13039/501100000269 O Award O ID: O ES/K001329/1 B-AWARD Mark O H. O Johnson O Medical B-ORG Research I-ORG Council I-ORG https://dx.doi.org/10.13039/501100000265 O Award O ID: O G0701484 B-AWARD Mairéad O MacSweeney O Wellcome B-ORG Trust I-ORG https://dx.doi.org/10.13039/100004440 O Award O ID: O 100229/Z/12/Z B-AWARD This O study O was O supported O by O funding O from O the O National B-ORG Research I-ORG Foundation I-ORG Singapore I-ORG NRF-003-CRP-002 O the O Goh B-ORG Foundation I-ORG Duke-NUS-GCR/2013/008 O and O Biomedical B-ORG Research I-ORG Council I-ORG Singapore I-ORG BMRC O 13/1/96/19/86 B-AWARD to O W.S O Medical B-ORG Research I-ORG Council I-ORG 1916606 O 1926882 B-AWARD to O C.F.R O as O part O of O a O CASE O studentship O with O Qiagen O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG BB/N000358/1 O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG Manchester I-ORG Biomedical I-ORG Research I-ORG Centre I-ORG IS-BRC-1215-20007 O to O W.G.N O and O T.A.B O This O study O has O received O funding O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Number O 81873908 B-AWARD the O Scientific B-ORG Research I-ORG Fund I-ORG of I-ORG Zhejiang I-ORG University I-ORG Grant O Number O XY2021032 B-AWARD XY2021034 B-AWARD and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O Number O 2019YFE0117400 B-AWARD This O research O was O financially O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0400105 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31972121 O Shanghai B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG 18391901400 O and O Shanghai O Municipal O Agricultural O and O Rural O Committee O 2019-02-08-00-02-F01146 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 31670207 B-AWARD to O Lei O Xie O the O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG no. O 5182016 B-AWARD to O Lei O Xie O and O the O Medium B-ORG and I-ORG Long-term I-ORG Scientific I-ORG Study I-ORG Projects I-ORG for O Young O Teachers O of O Beijing O Forestry O University O no. O 2015ZCQ-BH-03 B-AWARD to O Lei O Xie O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O in O part O by O grants O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81471195 O Basic B-ORG research I-ORG of I-ORG Suzhou I-ORG Medical I-ORG and I-ORG health I-ORG care I-ORG SYS201724 O Suzhou B-ORG Clinical I-ORG Research I-ORG Center I-ORG of I-ORG Neurological I-ORG Disease I-ORG Szzx201503 O the B-ORG Second I-ORG Affiliated I-ORG Hospital I-ORG of I-ORG Soochow I-ORG University I-ORG Preponderant I-ORG Clinic I-ORG Discipline I-ORG Group I-ORG Project I-ORG Funding I-ORG XKQ2015002 O Suzhou B-ORG health I-ORG science I-ORG and I-ORG technology I-ORG project I-ORG Gwzx201503 O This O was O also O partly O supported O by O the B-ORG Priority I-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O This O work O was O supported O by O grants O from O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2015RC002 O to O ZX, O Huazhong B-ORG Agricultural I-ORG University I-ORG Scientific I-ORG I-ORG Technological I-ORG Self-Innovation I-ORG Foundation I-ORG 2662016PY093 O to O ZX, O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31873045 O to O ZX, O and O USDA B-ORG AFRI I-ORG Grant I-ORG 2017-67015-26798 O to O IS. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O an O Alfred B-ORG P. I-ORG Sloan I-ORG Foundation I-ORG Postdoctoral B-AWARD Fellowship I-AWARD Award O to O AJP O a O National B-ORG Institutes I-ORG of I-ORG Health I-ORG New O Innovator O Award O 1-DP2-A1112243 O and O the O National B-ORG Science I-ORG Foundation I-ORG CBET-1438103 O and O ECCS-1542100 B-AWARD Additional O support O was O provided O by O the O Virginia O Tech O Institute O for O Critical O Technology O and O Applied O Science O This O study O was O funded O by O the O Fourth O National O Giant O Panda O Survey O initiated O by O the O Chinese B-ORG State I-ORG Forestry I-ORG Administration I-ORG SFA O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31300319 O Chinese O State O Forestry O Administration O No. O CM1423 B-AWARD WWF-China B-ORG No. O 10002980 B-AWARD Mianyang B-ORG Normal I-ORG University I-ORG QD2014A001,QD2012A12 O also O provided O financial O support O for O this O study O We O thank O Jiansheng O Jia O Director O of O Wildlife O Conservation O Department O at O SFA O for O providing O supporting O during O our O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O MISIONES-CDTI B-ORG program I-ORG CDTI O Centre O for O the O Development O of O Industrial O Technology O CULTUREDMEAT B-AWARD Project I-AWARD MIG-20201012 O by O the O Junta B-ORG de I-ORG Andalucía I-ORG CTS O 164 O and O by O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III I-ORG ISCIII)(PI19/01058 O with O funds O from O the O European O Union O The O CIBER-EHD O is O funded O by O the O ISCIII O M.J.R.-S O is O a O predoctoral O fellow O from O ISCIII O IFI21/00030 O “Programa O de O Doctorado O Biomedicina” O A.J.R.-M O is O a O predoctoral O fellow O from O University O of O Granada O “Formación O de O Profesorado O Universitario” O Program O “Programa O de O Doctorado O Medicina O Clínica O y O Salud O Pública” O This O study O was O partially O supported O by O grants O from O the O Japanese O Ministry O of O Health O Labour O and O Welfare O Respiratory O Failure I-AWARD 17933141 B-AWARD Y.I O Pulmonary B-AWARD alveolar I-AWARD proteinosis I-AWARD 17930161 O H26-Nanchitoo B-AWARD Nan)-ippann-076 O Y.I O T.A O M.A O and O M.K O Intractable B-ORG Respiratory I-ORG Diseases I-ORG and I-ORG Pulmonary I-ORG Hypertension I-ORG Research I-ORG Group I-ORG of I-ORG the I-ORG Ministry B-ORG of I-ORG Health I-ORG Labour I-ORG and I-ORG Welfare I-ORG 17933141 O Y.I O the B-ORG Japan I-ORG Agency I-ORG for I-ORG Medical I-ORG Research I-ORG and I-ORG Development I-ORG JP18ek0109268 O Y.I O and O the B-ORG National I-ORG Hospital I-ORG Organization I-ORG Respiratory I-ORG Diseases I-ORG Network I-ORG H26-NHO O Kokyu)-01 O Y.I O T.A O M.A O and O M.K O Support O was O provided O by: O 1) O the B-ORG Key I-ORG Foundation I-ORG Project I-ORG of I-ORG Basic I-ORG Work I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2012FY111400 O to O LSL O http://program.most.gov.cn O 2) O the B-ORG Strategic I-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDA20040200 O to O YLZ O http://www.bmrdp.cas.cn/alzx O 3) O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 41671104 B-AWARD to O LSL O http://www.nsfc.gov.cn O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O partly O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 8135002 O the O Clinical B-ORG Support I-ORG Foundation I-ORG of I-ORG Chinese I-ORG PLA I-ORG General I-ORG Hospital I-ORG 2012FC-TSYS-2004 O 2013FC-TSYS-2015 B-AWARD and O the O Central B-ORG Health I-ORG Special I-ORG Research I-ORG Projects I-ORG 13BJZ26 O This O work O was O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG 15ZR1436700 O and O Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Talents I-ORG Project I-ORG 14XD1425100 O and O the O Scientific B-ORG Research I-ORG Project I-ORG in I-ORG Public I-ORG Agricultural I-ORG Industry I-ORG 201403032 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O KM. O This O research O was O supported O by O the O Consortium O for O Advanced O Research O Training O in O Africa O CARTA O CARTA O is O jointly O led O by O the O African O Population O and O Health O Research O Center O and O the O University O of O the O Witwatersrand O and O funded O by O the O Carnegie B-ORG Corporation I-ORG of I-ORG New I-ORG York I-ORG Grant O No-G-19-57145 O Sida B-ORG Grant O no. I-AWARD 54100113 O Uppsala B-ORG Monitoring I-ORG Centre I-ORG and I-ORG the I-ORG DELTAS I-ORG Africa I-ORG Initiative I-ORG Grant O No: I-AWARD 107768/Z/15/Z O The O DELTA O Africa O Initiative O is O an O independent O funding O scheme O of O the O African O Academy O of O Sciences O AAS O Alliance O for O the O Accelerating O Excellence O in O Science O in O Africa O AESA O and O supported O by O the O New O Partnership O for O Africa’s O Development O Planning O and O Coordinating O Agency O NEPAD O Agency O with O funding O from O Wellcome O Trust O UK) O and O the O UK O government O The O statement O made O and O views O expressed O are O solely O the O responsibility O of O the O Fellow O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo I-ORG FAPESP O grants O numbers O 2016/24916-2 B-AWARD and O 2019/11113-7 B-AWARD Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior—Brasil I-ORG CAPES O Finance B-AWARD Code I-AWARD 001 O and O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq O grant O number O 310686/2022-9 B-AWARD Y.C O is O supported O by O the O China B-ORG Scholarship I-ORG Council O grant O number O 201606010345 B-AWARD C.S O and O J.K O are O supported O by O the O Deutsche B-ORG Forschungsgemeinschaft I-ORG DFG O German O Research O Foundation O project O number O KI B-AWARD 2085/1-1 O J.K O is O also O supported O by O the O Bergens B-ORG Forskningsstiftelse I-ORG BFS O Bergen O Research O Foundation O grant O number O BFS2017TMT01 B-AWARD This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61974093 O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Commission I-ORG of I-ORG Shenzhen I-ORG JCYJ20180507182042530 O JCYJ20180507182000722 B-AWARD and I-AWARD JCYJ20180305124214580 O Guangdong B-ORG Provincial I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2018B030306028 O Guangdong B-ORG Province I-ORG Special I-ORG Support I-ORG Plan I-ORG for I-ORG High-Level I-ORG Talents I-ORG 2017TQ04X082 O This O study O was O supported O by O grants O from O Shandong B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Program I-ORG no. O 2014GSF121004 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG China I-ORG ZR2014HP025 O National B-ORG Natural I-ORG Science I-ORG Funds I-ORG of I-ORG China I-ORG 31570167 O 81401368 B-AWARD This O work O was O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC1308800 O to O Ping O Lan O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2015CB554001 O to O Jian-ping O Wang O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81372142 O to O Hongzhi O Zou O Supported O by O National O Key O Clinical O Discipline O and O Creative O Biosciences O Guangzhou O CO O Ltd O This O work O is O partly O supported O by O the O Jiangsu B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG BE2021012-2 O and O BE2021012-5 B-AWARD Key B-ORG Laboratory I-ORG of I-ORG Brain I-ORG Machine I-ORG Collaborative I-ORG Intelligence I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2020E10010-04 O Human–Machine B-ORG Intelligence I-ORG and I-ORG Interaction I-ORG International I-ORG Joint I-ORG Laboratory I-ORG Project I-ORG and I-ORG Changzhou I-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG CE20225034 O and O Postgraduate B-ORG Research I-ORG I-ORG Practice I-ORG Innovation I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG KYCX22_3075 O This O work O was O supported O by O the O Special B-ORG Health I-ORG Research I-ORG Project I-ORG Ministry I-ORG of I-ORG Health I-ORG of I-ORG China I-ORG under O Grant O 201002012 O the O Chongqing B-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG under O Grant O 20141027 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81202220 B-AWARD This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.31772573 O and I-AWARD No. I-AWARD 31972556 O Key B-ORG Project I-ORG of I-ORG Natural I-ORG Science I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG Shaanxi I-ORG Province I-ORG No.2019JZ-07 O and O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG China I-ORG 2018ZX08010-09B O The O funding O bodies O played O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O nor O in O writing O the O manuscript O This O study O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 81772225 B-AWARD to O JC O the B-ORG Chinese I-ORG Special I-ORG Program I-ORG for I-ORG Scientific I-ORG Research I-ORG of I-ORG Public I-ORG Health I-ORG no. O 201502021 B-AWARD to O JC) O and O the B-ORG Fourth I-ORG Round I-ORG of I-ORG Three-Year I-ORG Public I-ORG Health I-ORG Action I-ORG Plan I-ORG of I-ORG Shanghai I-ORG China I-ORG no. O 15GWZK0101 B-AWARD to O JC O The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O the O decision O to O publish O or O preparation O of O the O manuscript O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFF0204800 O 2018YFB2001402 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG DUT19RC(4)007 O DUT16TD20 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U1508211 O This O research O was O jointly O supported O by O the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-02 O the O National B-ORG Natural I-ORG Science I-ORG Fund I-ORG 51309226 O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG ASTIP O the O Special O Fund O for O Agro-scientific O Research O in O the O Public O Interest O 201203077 O and O 201503117 O and O the O Natural O Science O Foundation O of O Henan O Province O 162300410154 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O During O the O whole O course O of O this O study O the O study O design O data O collection O data O analysis O data O interpretation O and O manuscript O preparation O were O mainly O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81800220 O and O Hunan B-ORG province I-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2019JJ50890 O Part O of O the O data O analysis O which O is O the O prenatal O diagnosis O was O supported O by O Hebei B-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG 17277728D O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 21203164 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG grant O number O ZR2017MB055 B-AWARD China O Postdoctoral O Science O Foundation O Funded O Project O grant O number O 2015M581691 O and O Jiangsu B-ORG Planned I-ORG Projects I-ORG for I-ORG Postdoctoral I-ORG Research I-ORG Funds I-ORG grant O number O 1501047B B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31601918 O 31522055 B-AWARD and O 31401073 B-AWARD the O National O Program O for O Support O of O Top-notch O Young O Professionals O the O Program B-ORG for I-ORG Innovative I-ORG Research I-ORG Team I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2015TD0012 O the O Fund O of O Fok B-ORG Ying-Tung I-ORG Education I-ORG Foundation I-ORG 141117 O and O the O Key O Project O of O Sichuan B-ORG Education I-ORG Department I-ORG 15ZA0003 O 16ZA0025 B-AWARD and O 15ZA0008 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG nos O 42201126 B-AWARD U2243231 B-AWARD and O 41971037 B-AWARD the O Open B-ORG Foundation I-ORG of I-ORG the I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Urban I-ORG and I-ORG Regional I-ORG Ecology I-ORG of I-ORG China I-ORG no. O SKLURE2020-2-3 B-AWARD and O the O Scientific B-ORG Research I-ORG Plan I-ORG Project I-ORG of I-ORG Tianjin I-ORG Municipal I-ORG Education I-ORG Commission I-ORG no. O 2019KJ091 B-AWARD This O work O was O financially O supported O by O Scientific B-ORG Research I-ORG Projects I-ORG of I-ORG universities I-ORG in I-ORG Anhui I-ORG Province I-ORG No. O 2022AH051154 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81703800 B-AWARD and O the B-ORG First I-ORG Affiliated I-ORG Hospital I-ORG of I-ORG Anhui I-ORG Medical I-ORG University I-ORG for I-ORG the I-ORG Cultivation I-ORG Program I-ORG of I-ORG Youth I-ORG Science I-ORG Foundation I-ORG No. O 2792 B-AWARD This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81671596 B-AWARD and O No. O 81971464 B-AWARD Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province O China O No. O 2017B020209001 B-AWARD the B-ORG National I-ORG Science I-ORG Foundation I-ORG of I-ORG Young I-ORG Scientists I-ORG of I-ORG China I-ORG No. O 31700795 B-AWARD the B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2019B020229001 B-AWARD and O Sanming B-ORG Project I-ORG of I-ORG Medicine I-ORG in I-ORG Shenzhen I-ORG No. O SYJY201704 B-AWARD and O No. O SYJY201705 O Ryckie O Wade O is O a O Doctoral O Research O Fellow O funded O by O the O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG NIHR O DRF-2018-11-ST2-028 B-AWARD This O research O is O also O supported O by O the O NIHR O Leeds O Biomedical O Research O Centre O and O University O of O Leeds O Advanced O Imaging O Centre O which O is O funded O by O the O Medical B-ORG Research I-ORG Council I-ORG MR/M008991/1 O with O support O from O the O British B-ORG Heart I-ORG Foundation I-ORG BHF-SP/14/7/31351 O and O Arthritis B-ORG Research I-ORG UK I-ORG ARUK-21078 O The O views O expressed O are O those O of O the O author(s O and O not O necessarily O those O of O the O United O Kingdom’s O National O Health O Service O NIHR O or O Department O of O Health O SP O is O funded O by O a O British O Heart O Foundation O Chair O CH/16/2/32089 O This O work O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O No. O 51575157 B-AWARD and O No. O 61473113 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG under O Grant O No. O E2016202342 B-AWARD supported O by O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Robotics I-ORG under O Grant O No. O 2015002 B-AWARD and O Beijing B-ORG Advanced I-ORG Innovation I-ORG Center I-ORG for I-ORG Intelligent I-ORG Robots I-ORG and I-ORG Systems I-ORG under O Grant O No. O 2018IRS04 B-AWARD This O work O was O supported O by O grants O from O National B-ORG Hi-Tech I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2014AA021203 O the B-ORG Science I-ORG and I-ORG Technology I-ORG Service I-ORG Network I-ORG Initiative I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG KFJ-STS-QYZD-047 O and O KFJ-EW-STS-078 B-AWARD and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31100074 O 21390202 B-AWARD and O 21436002 B-AWARD This O work O was O financially O supported O by O the B-ORG Twelfth I-ORG Five I-ORG Year I-ORG Plan I-ORG for I-ORG Breeding I-ORG Program I-ORG in I-ORG Sichuan I-ORG No. O 2011NZ0099-7 O the B-ORG thirteenth I-ORG Five I-ORG Year I-ORG Plan I-ORG for I-ORG Breeding I-ORG Program I-ORG in I-ORG Sichuan I-ORG No. O 2016NYZ0050 O the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG No. O CARS-41 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31601936 O The O study O was O sponsored O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81570317 O and O 81100075 B-AWARD and O Grants O for O China B-ORG Young/Middle-Aged I-ORG Clinical I-ORG Study I-ORG Fund-V.G I-ORG 2017-CCA-VG-031 O and O Research B-ORG Foundation I-ORG of I-ORG Zhongshan I-ORG Hospital I-ORG 2019ZSYXGG13 O This O work O was O financially O supported O by O Henan B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 202300410366 B-AWARD Henan B-ORG Provincial I-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG No. O 232102111114 B-AWARD the O Program B-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Talents I-ORG in I-ORG Universities I-ORG of I-ORG Henan I-ORG Province I-ORG No. O 19HASTIT014 B-AWARD Youth B-ORG Innovation I-ORG Project I-ORG of I-ORG Key I-ORG Discipline I-ORG of I-ORG Zhengzhou I-ORG University I-ORG No. O XKZDQN202002 B-AWARD and O the O Fostering B-ORG Project I-ORG for I-ORG Basic I-ORG Research I-ORG of I-ORG Zhengzhou I-ORG University I-ORG No. O JC21310015 B-AWARD This O study O was O funded O by O the O National B-ORG Key I-ORG R I-ORG I-ORG D I-ORG Program I-ORG of I-ORG China I-ORG 2019YFC1605402 O Three B-ORG New I-ORG Aquatic I-ORG Projects I-ORG in I-ORG Jiangsu I-ORG Province I-ORG D2017-3-1 O Independent B-ORG Innovation I-ORG Fund I-ORG of I-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG in I-ORG Jiangsu I-ORG Province I-ORG CX(17)2027 O CX(18)2011 O and O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O The O funders O had O no O role O in O the O design O of O the O study O data O collection O and O analysis O or O preparation O of O the O manuscript O This O project O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81472027 O to O SKW O Key B-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG of I-ORG Nanjing I-ORG Medicine I-ORG ZDX16001 O and O Innovation B-ORG team I-ORG of I-ORG Jiangsu I-ORG provincial I-ORG health-strengthening I-ORG engineering I-ORG by I-ORG science I-ORG and I-ORG education I-ORG CXTDB2017008 O to O SKW O This O project O was O also O supported O by O grants O from O Jiangsu B-ORG Youth I-ORG Medical I-ORG Talents I-ORG Training I-ORG Project I-ORG to O BSH O QNRC2016066 O and O YQP O QNRC2016074 O and O Nanjing B-ORG Medical I-ORG Science I-ORG and I-ORG Technique I-ORG Development I-ORG Foundation I-ORG to O BSH O No. O JQX13003 O This O research O was O funded O byFundação O para I-ORG a I-ORG Ciência I-ORG e I-ORG Tecnologia(FCT O through O the O research O project O PEST(bio)CIDE O PCIF/GVB/0150/2018 O and O byFundação O La I-ORG Caixa/BPIin O cooperation O with O FCT O through O the O research O project O CC&NUTS O within O the O scope O of O the O fourth O edition O ofPrograma O Promove(PD21-00007 O This O research O was O also O supported O through O FCT/MCTES B-ORG within O the O scope O of O UIDB/05748/2020 B-AWARD and O UIDP/05748/2020 B-AWARD GreenUPorto O S.S O F.S O M.P O M.M O and O B.S O also O acknowledge O FCT O for O providing O Ph.D O scholarships O S.S O 2021.07825.BD B-AWARD F.S O 2021.04941.BD B-AWARD M.P O 2021.07342.BD B-AWARD M.M O SFRH/BD/143268/2019 B-AWARD and O B.S O 2020/07826/BD B-AWARD This O work O was O supported O by O the O Special B-ORG Fund I-ORG for I-ORG Hunan I-ORG Forestry I-ORG Science I-ORG and I-ORG Technology I-ORG XLK201812 O to O N.D O Forestry B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG Hunan I-ORG Province I-ORG HNGYL-2019-01 O to O N.D O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O China O No. O 2018A0303130163 I-AWARD to O C.H O The O funding O body O had O no O influence O over O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O project O has O received O funding O from O the O Agence B-ORG Nationale I-ORG de I-ORG la I-ORG Recherche I-ORG ANR O grant O No. O BioHSFS O ANR-15-CE11-0007 B-AWARD the O European B-ORG Research I-ORG Council I-ORG ERC O grant O agreement O No O 772257 B-AWARD and O the O Human B-ORG Frontier I-ORG Science I-ORG Program I-ORG HFSP O grant O No. O RGP0056/2018 B-AWARD This O article O is O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China(81772098 O Clinical B-ORG research I-ORG booster I-ORG program(JYL027 O Shanghai B-ORG Health I-ORG Municipal I-ORG Bureau I-ORG foundation(20152227 O and O National O Natural O Science O Foundation O of O China(81071569 O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81973229/81660584 B-AWARD Key O Research O and O Development O Program O of O Hainan O Province O ZDYF2017099 O Key B-ORG Project I-ORG of I-ORG Education I-ORG Department I-ORG of I-ORG Hainan I-ORG Province I-ORG Hnky2019ZD-6 O and O Research B-ORG initiation I-ORG fund I-ORG project I-ORG of I-ORG Hainan I-ORG University I-ORG No.KYQD(ZR)20001).This O work O was O financially O supported O by O the O High-level B-ORG Talents I-ORG Programs I-ORG of I-ORG Hainan I-ORG Province I-ORG No. O 2019RC006 B-AWARD This O research O was O funded O by O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo I-ORG FAPESP O process O 2012/21915-4 B-AWARD Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq O process O 474307/2013-1 B-AWARD and O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG CAPES O Finance O Code O 001 B-AWARD This O research O was O funded O by O 1. O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China O grant O number O 2019YFD0900200 B-AWARD 2. O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 31972808 B-AWARD 3. O Science B-ORG and I-ORG Technology I-ORG Bureau I-ORG of I-ORG Zhanjiang O grant O number O 2020A05003 B-AWARD 4. O China B-ORG Agriculture I-ORG Research I-ORG System O grant O number O CARS-47 B-AWARD 5. O Department B-ORG of I-ORG Education I-ORG of I-ORG Guangdong I-ORG Province O grant O number O 2021ZDZX4005 B-AWARD This O research O was O financially O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG nos O 31672142 B-AWARD and O 31501771 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG of I-ORG China I-ORG nos O 2017JM3019 B-AWARD and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG nos O Z109021703 B-AWARD This O work O was O supported O by O Grants O from O the O Cross-Institute B-ORG Research I-ORG Fund I-ORG of I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG YG2017ZD01 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61472246 O and O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2013CB956103 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51534003 I-AWARD to O F.R O the B-ORG National I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFC0801601 I-AWARD to O F.R O and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O N150104006 I-AWARD to O R.H O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O research O grants O from O Heilongjiang B-ORG Province I-ORG Youth I-ORG Fund I-ORG QC2013C083 O Heilongjiang B-ORG Province I-ORG Education I-ORG Bureau I-ORG 12531617 O Heilongjiang B-ORG Province I-ORG R I-ORG I-ORG D I-ORG project I-ORG for I-ORG Applied I-ORG Technology I-ORG PS13H14 O and O National B-ORG 863 I-ORG Program I-ORG 2006AA02Z4B1 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O is O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFA0200200 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 52090030 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. O LTGY23E050002 B-AWARD Fujian B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Projects I-ORG No. O 2018HZ0001-2 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 2021FZZX001-17 B-AWARD Zhijiang B-ORG Youth I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Provincial I-ORG Philosophy I-ORG and I-ORG Social I-ORG Science I-ORG Planning I-ORG No. O 22ZJQN14YB B-AWARD the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Programme I-ORG of I-ORG Zhejiang I-ORG No. O 2023C03196 B-AWARD No. O 2022C03148 B-AWARD and O Key B-ORG Laboratory I-ORG of I-ORG Novel I-ORG Adsorption I-ORG and I-ORG Separation I-ORG Materials I-ORG and I-ORG Application I-ORG Technology I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 512301-I21502 O This O work O was O supported O by O the O Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG under O grant O numbers O 2022JDRC0134 B-AWARD 2022YFH0110 B-AWARD and O 2021YFSC0040 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG 2030-Brain I-ORG Science I-ORG and I-ORG Brain-inspired I-ORG Artificial I-ORG Intelligence I-ORG Key I-ORG Project I-ORG under O grant O number O 2022ZD0208506 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG under O grant O numbers O 2016YFC0100800 B-AWARD and O 2016YFC0100802 B-AWARD the O Foundation B-ORG of I-ORG Ph.D I-ORG Scientific I-ORG Research I-ORG of I-ORG Neijiang I-ORG Normal I-ORG University I-ORG under O grant O number O 18B19 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG funded O under O grant O number O 2020M683294 B-AWARD and O projects O funded O by O the O Sichuan B-ORG Applied I-ORG Psychology I-ORG Research I-ORG Center I-ORG of I-ORG Chengdu I-ORG Medical I-ORG College I-ORG under O grant O number O CSXL-21103 B-AWARD Much O appreciated O financial O support O was O provided O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31571650 O and O 31771785 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0100701 O the O Key B-ORG Projects I-ORG in I-ORG Shaanxi I-ORG Provincial I-ORG Agricultural I-ORG Field I-ORG 2018ZDXM-NY-006 O and O the O Tang O Zhongying O Breeding O Funding O Project O at O Northwest O A&F O University O This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program O of O China O 2017YFC1103800 O the O HongKong B-ORG Macao I-ORG and I-ORG Taiwan I-ORG Science I-ORG I-ORG Technology I-ORG Cooperation I-ORG Program O of O China O 2015DFH30180 O the O Science B-ORG and I-ORG Technology I-ORG Support I-ORG Program O of O Hubei O Province O 2015BCE022 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for O the O Central O Universities O 2017IVA095 O This O work O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81370653 O National B-ORG Clinical I-ORG research I-ORG Base I-ORG construction I-ORG Projects I-ORG of I-ORG Traditional I-ORG Medicine I-ORG 2012H01 O and O Shanghai B-ORG Municipal I-ORG Education I-ORG Commission-Gaofeng I-ORG Clinical I-ORG Medicine I-ORG Grant I-ORG Support I-ORG 20161406 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O has O been O supported O by: O Joint B-ORG Key I-ORG project I-ORG of I-ORG NSFC-Shenzhen I-ORG Robot I-ORG Foundation I-ORG Research I-ORG Center I-ORG No. O U1713215 B-AWARD Shenzhen B-ORG Key I-ORG Basic I-ORG Research I-ORG Grant I-ORG No. O JCYJ20160331191401141 B-AWARD and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61671440 B-AWARD This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O Grant O No. O 81270026 B-AWARD the O National O S O O T O Major O Program O Grant O No. O 2012ZX10004-220 O the O Special B-ORG Fund I-ORG for I-ORG Health I-ORG Research I-ORG in I-ORG the I-ORG Public O Interest O Grant O No. O 201202019 B-AWARD and O the O Program B-ORG for I-ORG Changjiang I-ORG Scholars I-ORG and I-ORG Innovative O Research O Team O in O University O IRT13007 O DPM O is O a O NHMRC O Senior O Principal O Research O Fellow O and O Senior O Scientist O at O QIMR O Berghofer O Medical O Research O Institute O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O A.R O was O supported O by O the O Medical B-ORG Research I-ORG Council I-ORG MR/N013638/1 O S.F O was O supported O by O a O Wellcome B-ORG Trust I-ORG Senior I-ORG Research I-ORG Fellowship I-ORG in I-ORG Basic I-ORG Biomedical I-ORG Science I-ORG 210758/Z/18/Z O A.J.K O was O supported O by O a O Sir B-ORG Henry I-ORG Dale I-ORG Fellowship I-ORG jointly I-ORG funded I-ORG by I-ORG the I-ORG Wellcome I-ORG Trust I-ORG and I-ORG the I-ORG Royal I-ORG Society I-ORG 206250/Z/17/Z O This O work O was O supported O by O theUnited O Kingdom I-ORG Medical I-ORG Research I-ORG Council(MRC O grantsG0801742andG0802780(to O W.H.I.M O Fight O for O Sight O UK) O grants O 1880 O and O 1450/1451 O to O W.H.I.M O and O C.B.T.M.),Wellcome O Trust I-ORG Strategic I-ORG Award098439/Z/12/Z(to O W.H.I.M O and O theDanish O Council I-ORG for I-ORG Independent I-ORG Research-Medical I-ORG Sciences(DFF-4004-00471 O Funding O to O pay O the O Open O Access O publication O charges O for O this O article O was O provided O by O The O Wellcome O Trust O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31741045 O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Leading I-ORG Plan I-ORG for I-ORG Hunan I-ORG Provincial I-ORG High-Tech I-ORG Industry I-ORG 2020SK2018 O the O Key B-ORG Project I-ORG Supported I-ORG by I-ORG Scientific I-ORG Research I-ORG Fund I-ORG of I-ORG Hunan I-ORG Provincial I-ORG Education I-ORG Department I-ORG 19A227 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O nos O 31371559 B-AWARD and O 31571599 B-AWARD the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2019FZA6011 O and O Jiangsu B-ORG Collaborative I-ORG Innovation I-ORG Center I-ORG for I-ORG Modern I-ORG Crop I-ORG Production I-ORG JCIC-MCP O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grants O number O 42167058 B-AWARD U1903209 B-AWARD and O 51704259 B-AWARD This O research O was O also O funded O by O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG grant O number O 2018M633609 B-AWARD and O the O doctoral O research O project O of O Xinjiang B-ORG University I-ORG grant O number O XJBS-2018 B-AWARD This O research O was O funded O by O the O Fund B-ORG Exploration I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG grant O number O LTGN23B050001 B-AWARD project O leader O Xianshu O Fu O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Province I-ORG grant O number O 2020C02024 B-AWARD project O leader O Zihong O Ye; O and O grant O number O 2021C02061 B-AWARD project O leader O Xiaoping O Yu O the O Leading B-ORG Talents I-ORG in I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG of I-ORG Ten I-ORG Thousand I-ORG Talents I-ORG Program I-ORG in I-ORG Zhejiang I-ORG Province I-ORG grant O number O 2019R52018 B-AWARD project O leader O Zihong O Ye O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O number O 2021YFF0602801 B-AWARD project O leader O Mingzhou O Zhang O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 31901781 B-AWARD project O leader O Yulou O Qiu O and O the O Agricultural B-ORG and I-ORG Social I-ORG Development I-ORG Projects I-ORG of I-ORG Hangzhou I-ORG grant O number O 20201203B117 B-AWARD project O leader O Jinyan O Liao O The O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO. O 81973801 B-AWARD Capital’s B-ORG Funds I-ORG for I-ORG Health I-ORG Improvement I-ORG and I-ORG Research I-ORG NO. O 2018-1-4161 O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG China I-ORG Academy I-ORG of I-ORG Chinese I-ORG Medical I-ORG Sciences I-ORG NO. O CI2021A01609).The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O We O gratefully O acknowledge O the O funding O support O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC1305703 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81670750 O 81971191 B-AWARD and O 61627807 B-AWARD Guangxi B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2014GXNSFDA118030 O and O the O Scientific O Research O Foundation O for O the O Returned O Overseas O Chinese O Scholars O State O Education O Ministry O This O research O was O financially O supported O by O NSFC B-ORG 61527806 O 61401217 B-AWARD 61471168 B-AWARD and O 61571187 B-AWARD Chinese B-ORG 863 I-ORG Project I-ORG 2015AA020502 O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFA0205300 O Open B-ORG Funding I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Oral I-ORG Diseases I-ORG SKLOD2017OF04 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2016T90403 O and O the B-ORG Economical I-ORG Forest I-ORG Cultivation I-ORG and I-ORG Utilization I-ORG of I-ORG 2011 I-ORG Collaborative I-ORG Innovation I-ORG Center I-ORG in I-ORG Hunan I-ORG Province I-ORG (2013 O 448 O This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC0910201 O the O Key B-ORG R&D I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2019B020226001 O and O the B-ORG Science I-ORG and I-ORG the I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangzhou I-ORG 201704020176 O This O work O was O supported O by O the O National B-ORG Social I-ORG Science I-ORG Found I-ORG of I-ORG China I-ORG No. O 22XTJ004 B-AWARD the O General B-ORG Project I-ORG of I-ORG Philosophy I-ORG and I-ORG Social I-ORG Sciences I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O GD21CLJ03 B-AWARD the O Shaanxi B-ORG Soft I-ORG Science I-ORG Foundation I-ORG No. O 2022KRM171 B-AWARD This O work O was O partly O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82103944 O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0907200 O 2017YFC0907201 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Resources I-ORG Open I-ORG Sharing I-ORG Platform I-ORG of I-ORG the I-ORG Shaanxi I-ORG Province I-ORG 2023-CX-PT-47 O This O work O has O been O funded O by O the O National B-ORG Institutes I-ORG of I-ORG Health O USA O grant O R01 B-AWARD AI110112 I-AWARD to O JEC O MAMS O is O funded O by O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo I-ORG FAPESP O grant O no. O 2014/26229-7 B-AWARD and O Conselho B-ORG Nacional I-ORG de I-ORG Pesquisa I-ORG CNPq O no. O 301877/2016-5 B-AWARD The O Boren B-ORG Awards I-ORG fellowship I-ORG 2015 O and O the O Biodefense B-ORG and I-ORG Emerging I-ORG Infectious I-ORG Disease I-ORG training I-ORG fellowship I-ORG grant O T32AI05532901 O provided O partial O funding O support O to O VMC O This O work O was O supported O by O Postdoctoral B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG 2021K269B O the O National B-ORG Key I-ORG Research I-ORG I-ORG Developmental I-ORG Program I-ORG of I-ORG China I-ORG 2021YFC2100300 O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG of I-ORG Finance I-ORG and I-ORG Agriculture I-ORG Ministry I-ORG No. O CARS-11-HNSHY B-AWARD and O Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG for I-ORG Chinese I-ORG Academy I-ORG of I-ORG Tropical I-ORG Agricultural I-ORG Sciences I-ORG No. O 1630052021012 B-AWARD 1630052020023 B-AWARD 1630052020024 B-AWARD This O work O was O supported O by O the O Consejo B-ORG Nacional I-ORG de I-ORG Ciencia I-ORG y I-ORG Tecnología I-ORG through O CB-2007-01 O program O grant O number O 80031 B-AWARD the O Ministerio B-ORG de I-ORG Educación I-ORG y I-ORG Ciencia I-ORG grant O number O CGL2010-15964 B-AWARD and O the O Junta B-ORG de I-ORG Andalucía I-ORG grant O number O P09-RNM-4517 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Scientific B-ORG and I-ORG technological I-ORG innovation I-ORG joint I-ORG capital I-ORG projects I-ORG of I-ORG Fujian I-ORG Province I-ORG China I-ORG No.2016Y9031 B-AWARD Construction B-ORG Project I-ORG of I-ORG Fujian I-ORG Province I-ORG Minimally I-ORG Invasive I-ORG Medical I-ORG Center I-ORG No. B-AWARD 2017]171 O Fujian B-ORG province I-ORG medical I-ORG innovation I-ORG project I-ORG 2015-CXB-16 B-AWARD The O funding O bodies O were O neither O involved O in O the O design O of O the O study O nor O in O the O collection O analysis O or O interpretation O of O data O nor O in O the O writing O of O the O manuscript O This O work O was O supported O by O the B-ORG Special I-ORG Funds I-ORG for I-ORG the I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG from I-ORG Fujian I-ORG Provincial I-ORG Department I-ORG of I-ORG Health I-ORG Grant O No.wzhw201302 O the B-ORG Special I-ORG Funds I-ORG for I-ORG the I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Public I-ORG Wellbeing I-ORG from I-ORG Xiamen I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG Grant O No.3502Z20144030 O the B-ORG Medical I-ORG Innovation I-ORG Project I-ORG of I-ORG Fujian I-ORG China(Grant O No.2015-CXB-43)and O the B-ORG Special I-ORG Funds I-ORG from I-ORG the I-ORG Xiamen I-ORG Chuanming I-ORG Biological I-ORG Technology I-ORG Co. I-ORG Ltd O Grant O No.XDHT2015241A O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFC0210500 B-AWARD 2018YFC0213403 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 21477076 B-AWARD 2173700 B-AWARD This O work O was O also O supported O by O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2015M581625 B-AWARD and O 2015M581624 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG under I-ORG grant I-ORG 2023-JC-YB-587 O Key B-ORG Technologies I-ORG R I-ORG I-ORG D I-ORG Program I-ORG of I-ORG Tianjin I-ORG under O Grant O 20YFZCGX00440 O Shaanxi B-ORG Key I-ORG Laboratory I-ORG of I-ORG Deep I-ORG Space I-ORG Exploration I-ORG Intelligent I-ORG Information I-ORG Technology I-ORG under O Grant O 2021SYS-04 O This O work O was O supported O by O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81372342 B-AWARD and O 31501143 B-AWARD Nature B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG Grant O No. O 2014A030310168 B-AWARD Shenzhen B-ORG Peacock I-ORG Innovation I-ORG Team I-ORG Project I-ORG Grant O No. O KQTD20140630100658078 B-AWARD the O Key O Laboratory O Project O of O Shenzhen O ZDSY20130329101130496 O Shenzhen B-ORG basic I-ORG research I-ORG program I-ORG Grant O No. O JCYJ20150525092941006 B-AWARD JCYJ20150525092941030 B-AWARD and O JCYJ20170302143447936 B-AWARD Forestry B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG Guangdong I-ORG Grant O No. O 2017KJCX062 B-AWARD This O work O was O supported O by O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG 2013R1A6A3A04059121 O the O Strategic O Initiative O for O Microbiomes O in O Agriculture O and O Food O funded O by O the O Ministry B-ORG of I-ORG Agriculture I-ORG Food I-ORG and I-ORG Rural I-ORG Affairs I-ORG 916006-2 O and O the O Cooperative O Research O Program O for O Agricultural O Science O and O Technology O Development O Project O PJ01085602 B-AWARD Rural B-ORG Development I-ORG Administration O Republic O of O Korea O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O project O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O 81500757 B-AWARD 81702781 B-AWARD National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG 2018YFC1106100 O and O The O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG 17DZ2260100 O 19JC1410200 O The O funders O played O no O roles O in O the O study O design O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG PR I-ORG China O 2019YFE0119500 O 111 O Project O “State O Innovation O Base O for O Pulmonary O Fibrosis” O Henan B-ORG Natural I-ORG Science I-ORG Foundation I-ORG for I-ORG Young I-ORG Scholars I-ORG 202300410227 O and O Xinxiang B-ORG Major I-ORG Project I-ORG 21ZD002 O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFA0602704 O the O Strategic B-ORG Leading I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDA20020202 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41771050 O This O research O was O financially O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 52275069 B-AWARD 52275067 B-AWARD and O 52175065 B-AWARD the B-ORG Hebei I-ORG Natural I-ORG Science I-ORG Foundation I-ORG China I-ORG Grant O Nos O E2022203041 B-AWARD Open B-ORG fund I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Fluid I-ORG Power I-ORG and I-ORG Electromechanical I-ORG System I-ORG Grant O Nos O GZKF-202009 B-AWARD This O study O was O supported O by O a O grant O from O the O Seoul B-ORG National I-ORG University I-ORG Hospital I-ORG Research I-ORG Fund I-ORG 620172540 O and O the O Korea B-ORG National I-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF I-ORG funded I-ORG by I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG Science I-ORG and I-ORG Technology I-ORG 2014R1A1A2A16055218 O EKC O specifically O received O grants O from O the O Korean B-ORG Healthcare I-ORG Technology I-ORG R&D I-ORG project I-ORG funded I-ORG by I-ORG the I-ORG Ministry I-ORG of I-ORG Health I-ORG I-ORG Welfare I-ORG HI15C1200 O Biosense O Webster O IIS368 O IIS457 O Daiichi-Sankyo O 06-2017-1370 O and O BMS/Pfizer O CV185-704 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O specific O roles O of O these O authors O are O articulated O in O the O author O contributions O section O This O research O was O financially O supported O by O grants O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31471862 B-AWARD the B-ORG key I-ORG research I-ORG and I-ORG development I-ORG plans I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG grant O no. O 2017YFD0201103 B-AWARD and O 2018YFD0201406 B-AWARD and O the B-ORG earmarked I-ORG fund I-ORG for I-ORG Pear I-ORG Modern I-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG CARS-29-15 O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No.2016YFC0802904 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.61671470 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20161470 O 62nd O batch O of O funded O projects O of O China O Postdoctoral O Science O Foundation O No. O 2017M623423 O This O project O was O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG No. O 2018A030313379 O Shenzhen B-ORG Key I-ORG Laboratory I-ORG of I-ORG Single-Cell I-ORG Omics I-ORG NO. O ZDSYS20190902093613831 O the B-ORG Shenzhen I-ORG Municipal I-ORG Government I-ORG of I-ORG China I-ORG Peacock I-ORG Plan I-ORG No. O KQTD2015033017150531 O This O study O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31870179 B-AWARD 31570204 B-AWARD 31270237 B-AWARD J1310002 B-AWARD S B-ORG I-ORG T I-ORG Basic I-ORG Work I-ORG No. O 2014FY210300 B-AWARD 2013FY112100 B-AWARD Sino-Africa B-ORG Joint I-ORG Research I-ORG Centre I-ORG No. O SAJC201614 B-AWARD and O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG No. O XDA20040000 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O Grants-in-Aid O from O the O Japan B-ORG Agency I-ORG for I-ORG Medical I-ORG Research I-ORG and I-ORG Development I-ORG JP22bm0804005 O and O JP22ek0109488 B-AWARD the O Japan B-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG JP20H03561 O JP21K06392 B-AWARD and O JP21H04815 B-AWARD the O Ministry O of O Health O Labour O and O Welfare O of O Japan O 20FC1036 O and O the O National B-ORG Center I-ORG of I-ORG Neurology I-ORG and I-ORG Psychiatry I-ORG 2–5 O This O work O was O supported O by O the O Mega-projects B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG 2017ZX10303401 O Beijing B-ORG Nova I-ORG Program I-ORG Z171100001117102 O Military B-ORG Medical I-ORG Science I-ORG and I-ORG Technology I-ORG Youth I-ORG Cultivation I-ORG Program I-ORG 19QNP113 O and O Military B-ORG Logistics I-ORG Research I-ORG Program I-ORG BWS14C051 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Financial B-ORG funds I-ORG Project I-ORG of I-ORG Tianjin I-ORG No. O SCZ201801 B-AWARD the O Research B-ORG and I-ORG Extension I-ORG Project I-ORG of I-ORG the I-ORG Fishery I-ORG Development I-ORG and I-ORG Service I-ORG Center I-ORG of I-ORG Tianjin I-ORG No. O J2013-21 B-AWARD the O Youth B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG the I-ORG Fishery I-ORG Development I-ORG and I-ORG Service I-ORG Center I-ORG of I-ORG Tianjin I-ORG No. O J2018-07 B-AWARD and O the O Innovation B-ORG Team I-ORG of I-ORG Tianjin I-ORG Fisheries I-ORG Research I-ORG System I-ORG ITTFRS2017002 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82102688 O the O Clinical B-ORG Research I-ORG Fund I-ORG of I-ORG Wu I-ORG Jieping I-ORG Medical I-ORG Foundation I-ORG 320.6750.2021-04-67 O and O the O Children B-ORG Medication I-ORG Program I-ORG of I-ORG Beijing I-ORG Children’s I-ORG Hospital I-ORG MYZD202202 O This O work O was O partly O financed O by: O 1) O Statutory O Research O of O Chair O and O Department O of O Rehabilitation O and O Orthopaedics O of O Medical B-ORG University I-ORG in I-ORG Lublin I-ORG No. O DS B-AWARD 338/16 O 2) O Statutory O Research O of O Department O of O Animal O Physiology O University B-ORG of I-ORG Life I-ORG Sciences I-ORG in I-ORG Lublin I-ORG No. O WKF/DS/5 B-AWARD and O 3) O Statutory O Research O of O Department O of O Comparative O Anatomy O and O Anthropology O of O Maria B-ORG Curie-Skłodowska I-ORG University I-ORG No. O BS-01-1200-0000 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Medical O University O in O Lublin:www.umlub.pl/en O University O of O Life O Sciences O in O Lublin:www.up.lublin.pl/english O Maria O Curie-Skłodowska O University:www.umcs.pl/en O This O work O was O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51961135107 O 51774034 B-AWARD 51772026 B-AWARD 21801013 B-AWARD National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFE0119700 O Swedish O Research O Council O VR O and O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2182039 O This O study O was O funded O by O DFG B-ORG Research I-ORG Grants—GR4743/5-1 O to O B.G O and O GO B-AWARD 1392/8-1 I-AWARD to O M.G O European B-ORG Union O Marie O Skłodowska-Curie O Actions O MSCA O project O 101086322 B-AWARD HEPINIB O To O M.G O and O G.B O and O the O German B-ORG Academic I-ORG Exchange I-ORG Service I-ORG DAAD O German–Egyptian O Research O Long-Term O Scholarship O program O GERLS O Grant O 91664677 B-AWARD to O N.H O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31872748 O 81772358 I-AWARD 31500779 O Jiangsu B-ORG Provincial I-ORG Special I-ORG Program I-ORG of I-ORG Medical I-ORG Science I-ORG BL2012004 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2016M590500 O 2017T100398 O Jiangsu B-ORG Planned I-ORG Projects I-ORG for I-ORG Postdoctoral I-ORG Research I-ORG Funds I-ORG 1601269C O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81860150 O Special B-ORG Project I-ORG on I-ORG Innovation I-ORG Driven I-ORG Development I-ORG of I-ORG Guangxi I-ORG GuikeAA18118051 O and O National B-ORG Modern I-ORG Agricultural I-ORG Industrial I-ORG Technology I-ORG System I-ORG nycytxgxcxtd-15-01 O This O work O was O supported O by O the O Startup O Fund O for O the O 100 O Top O Talents O Program O SYSU O grant O number O 392012 O the O National B-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 71233001 B-AWARD 71490732 I-AWARD and I-AWARD 81573247 O the B-ORG U.S I-ORG National I-ORG Institute I-ORG of I-ORG Aging I-ORG I-ORG United I-ORG Nations I-ORG Fund I-ORG for I-ORG Population I-ORG Activities I-ORG grant O number O 2P01AG031719 B-AWARD and O Claude B-ORG D. I-ORG Pepper I-ORG Older I-ORG Americans I-ORG Independence I-ORG Centers I-ORG grant I-ORG grant O number O 5P30 B-AWARD AG028716 O The O funders O of O the O study O had O no O role O in O study O design O data O analysis O data O interpretation O or O writing O of O the O report O The O corresponding O authors O had O full O access O to O all O the O data O in O the O study O and O had O the O final O responsibility O to O submit O for O publication O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81471935 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC-NIH I-ORG project I-ORG No. O 81561128007 O the O Important B-ORG Key I-ORG Program I-ORG of I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81590765 O the O Introduction B-ORG of I-ORG Innovative I-ORG R&D I-ORG Team I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2009010058 O and O the O Joint-innovation B-ORG Program I-ORG in I-ORG Healthcare I-ORG for I-ORG Special I-ORG Scientific I-ORG Research I-ORG Projects I-ORG of I-ORG Guangzhou I-ORG China I-ORG No. O 201508020256 O This O study O was O funded O by O the B-ORG Youth I-ORG Foundation I-ORG of I-ORG Humanities I-ORG and I-ORG Social I-ORG Sciences I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG Grant O No. O 13YJC790142 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O No. O 71303040 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2013 B-AWARD M540268 O Planning B-ORG Program I-ORG of I-ORG Philosophy I-ORG and I-ORG Social I-ORG Sciences I-ORG Research I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG Grant O No.15JYD04 O King B-ORG Khalid I-ORG University I-ORG RCAMS/KKU/017-22 O Ministry B-ORG of I-ORG Education I-ORG Kingdom I-ORG of I-ORG Saudi I-ORG Arabia I-ORG PCSED-020-18 O Ajman B-ORG University I-ORG 2022-IRG-HBS-17b O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 31930041 O Y.Z O the B-ORG Knowledge I-ORG Innovation I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDA16030301 O Y.Z O and O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFA0105002 O 2017YFA0104402 B-AWARD Y.Z O This O research O was O funded O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grants O 81260331 B-AWARD and O 81360312 B-AWARD the B-ORG Graduate I-ORG Innovational I-ORG Foundation I-ORG of I-ORG Guangxi I-ORG grant O YCSZ2014108 B-AWARD and O the B-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG grant O 2012ZX10002010001009 B-AWARD Funding O support O was O provided O by O a O grant O from O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31571743 O and O 31671658 B-AWARD Chinese B-ORG national I-ORG ‘863’ I-ORG program I-ORG 2010AA101301 O and O a O grant O from O the O doctoral O fund O of O the O Educational B-ORG Ministry I-ORG of I-ORG China I-ORG 20130097110001 O This O research O was O supported O by O the O key B-ORG research I-ORG and I-ORG development I-ORG projects I-ORG in I-ORG Anhui I-ORG province I-ORG 2022a05020069 O the O educational B-ORG commission I-ORG of I-ORG Anhui I-ORG province I-ORG of I-ORG China I-ORG 2022AH040137 O 2022AH050990 B-AWARD key B-ORG laboratory I-ORG of I-ORG intelligent I-ORG textile I-ORG and I-ORG flexible I-ORG interconnection I-ORG of I-ORG Zhejiang I-ORG province I-ORG ZD04 O open B-ORG project I-ORG program I-ORG of I-ORG Anhui I-ORG engineering I-ORG and I-ORG technology I-ORG research I-ORG center I-ORG of I-ORG textile I-ORG 2021AETKL09 O the O scientific B-ORG research I-ORG project I-ORG of I-ORG Anhui I-ORG polytechnic I-ORG university I-ORG Xjky2022079 O 2022YQQ057 B-AWARD KH10002945 B-AWARD project O supported O by O the O scientific B-ORG research I-ORG activity I-ORG fund I-ORG for I-ORG post-doctoral I-ORG researchers I-ORG of I-ORG Anhui I-ORG province I-ORG 2022B590 O This O work O was O supported O by O grants O awarded O by O the O US O National B-ORG Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute I-ORG NIH O grant O R01HL137203 B-AWARD to O P.St O the O National B-ORG Organization I-ORG for I-ORG Rare I-ORG Disorders I-ORG 2016 O NORD O grant O 16001 B-AWARD to O P.Sz O and O the O US O National B-ORG Human I-ORG Genome I-ORG Research I-ORG Institute I-ORG NHGRI)/NHLBI O grant O number O UM1HG006542 B-AWARD to O the O Baylor-Hopkins O Center O for O Mendelian O Genomics O BHCMG O the O National B-ORG Institute I-ORG of I-ORG Neurological I-ORG Disorders I-ORG and I-ORG Stroke I-ORG NINDS O R35 B-AWARD NS105078 I-AWARD to O J.R.L O This O study O was O supported O by O the O National B-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 41471037 B-AWARD 41101049 I-AWARD 41371072 I-AWARD 41430857 O University B-ORG Nursing I-ORG Program I-ORG for I-ORG Young I-ORG Scholars I-ORG with I-ORG Creative I-ORG Talents I-ORG in I-ORG Heilongjiang I-ORG Province I-ORG No. O UNPYSCT-2015054 B-AWARD Excellent O Youth O Scholars O of O Harbin O Normal O University O and O Excellent B-ORG Youth I-ORG Scholars I-ORG of I-ORG Northeast I-ORG Institute I-ORG of I-ORG Geography I-ORG and I-ORG Agroecology I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG No. O DLSYQ2012004 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O project O and O the O preparation O of O this O publication O were O funded O in O part O by O the O Pittman-Robertson B-ORG Wildlife I-ORG Restoration I-ORG Grant I-ORG Program I-ORG Grant O AR-W-F18AF00020 B-AWARD of O the O U.S B-ORG Fish I-ORG and I-ORG Wildlife I-ORG Service I-ORG through O an O agreement O with O the O Arkansas O Game O and O Fish O Commission O The O views O and O opinions O expressed O herein O are O those O of O the O authors O and O do O not O necessarily O reflect O the O views O or O policies O of O the O Arkansas O Game O and O Fish O Commission O Product O references O do O not O constitute O endorsements;XSEDE O TG-BIO160065];U.S O Fish O and O Wildlife O Service O AR-W-F18AF00020 O This O work O was O funded O by O grant O National B-ORG Development I-ORG of I-ORG Key I-ORG Novel I-ORG Drugs I-ORG for I-ORG Special I-ORG Projects I-ORG of I-ORG China I-ORG 2017ZX09304014 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG 2019JJ50966 O and O also O supported O by O the O Hunan B-ORG Key I-ORG Laboratory I-ORG for I-ORG Bioanalysis I-ORG of I-ORG Complex I-ORG Matrix I-ORG Samples I-ORG 2017TP1037 O This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Beijing I-ORG Municipality I-ORG 7202062 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82071454 O Cooperation B-ORG Project I-ORG of I-ORG Chinese I-ORG Institute I-ORG for I-ORG Brain I-ORG Research I-ORG Beijing I-ORG 2020-NKX-XM-13 O and O Beijing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG Z211100002921032 O and O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2022YFC2503800 O awarded O to O L.R O The O authors O are O grateful O to O the O Ibero–American B-ORG Program I-ORG on I-ORG Science I-ORG and I-ORG Technology I-ORG CYTED—AQUA-CIBUS O P317RT0003 B-AWARD and O the O Bio B-ORG Based I-ORG Industries I-ORG Joint I-ORG Undertaking I-ORG JU) O under O grant O agreement O No. O 888003 B-AWARD UP4HEALTH O Project O H2020-BBI-JTI-2019 O The O JU O receives O support O from O the O European O Union’s O Horizon O 2020 O research O and O innovation O program O and O the O Bio O Based O Industries O Consortium O The O project O SYSTEMIC B-ORG Knowledge I-ORG Hub I-ORG on I-ORG Nutrition I-ORG and I-ORG Food I-ORG Security I-ORG has O received O funding O from O national O research O funding O parties O in O Belgium O FWO O France O INRA O Germany O BLE O Italy O MIPAAF O Latvia O IZM O Norway O RCN O Portugal O FCT O and O Spain O AEI O in O a O joint O action O of O JPI O HDHL O JPI-OCEANS O and O FACCE-JPI O launched O in O 2019 O under O the O ERA-NET O ERA-HDHL O n° O 696295 B-AWARD The O research O was O supported O by O a O grant O BST B-AWARD 164640 I-AWARD from O the O Faculty B-ORG of I-ORG Psychology I-ORG University I-ORG of I-ORG Warsaw O JO O and O by O a O grant O BMN2015 B-AWARD from O the O Collegium B-ORG of I-ORG World I-ORG Economy I-ORG Warsaw I-ORG School I-ORG of I-ORG Economics O AK. O The O preparation O of O the O manuscript O was O supported O by O a O grant O BMN2015 O from O the O Collegium O of O World O Economy O Warsaw O School O of O Economics O AK O and O by O a O grant O 2015/19/B/HS6/01633 B-AWARD from O the O National B-ORG Science I-ORG Centre I-ORG Poland O JO. O This O work O was O supported O by O grants O from O the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 863 O Program O 2014AA020610 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81771489 O Beijing B-ORG Municipal I-ORG Science I-ORG I-ORG Technology I-ORG Commission I-ORG Z171100000117002 O and O China B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2017YFC0908300 O This O research O was O funded O by O the B-ORG National I-ORG Barley I-ORG and I-ORG Highland I-ORG Barley I-ORG Industry I-ORG Technology I-ORG System I-ORG Program O grant O number O CARS-05-18 B-AWARD the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Henan O grant O number O 212300410228 B-AWARD the B-ORG Scientific I-ORG and I-ORG technological I-ORG Planning I-ORG in I-ORG Henan I-ORG Province O grant O number O 212102110314 B-AWARD the B-ORG Foundation I-ORG of I-ORG Central I-ORG Laboratory I-ORG of I-ORG Xinyang I-ORG Agriculture I-ORG and I-ORG Forestry I-ORG University O grant O number O FCL202014 B-AWARD and O the B-ORG Youth I-ORG Foundation I-ORG of I-ORG Xinyang I-ORG Agriculture I-ORG and I-ORG Forestry I-ORG University O grant O number O QN2022026 B-AWARD Loulou B-ORG Foundation I-ORG CDKL5-16-107-02 O UPenn B-ORG Orphan I-ORG Disease I-ORG Center O Rettsyndrome.org O HeART O 3510 O National B-ORG Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences I-ORG UL1 O TR001860 O KL2 B-AWARD TR001859 I-AWARD to O J.D.A O Funding O for O open O access O charge O LouLou O Foundation O This O work O was O supported O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31372394 B-AWARD and O Guangdong B-ORG Natural I-ORG Science I-ORG Foundations I-ORG Nos.2014A030313699 O and O 2015A030310094 B-AWARD and O North B-ORG Guangdong I-ORG Collaborative I-ORG Innovation I-ORG and I-ORG Development I-ORG Center I-ORG for I-ORG Swine I-ORG Farming I-ORG and I-ORG Disease I-ORG Control I-ORG No.YJK-2014-52-16 O This O study O was O supported O in O part O by O the O National B-ORG Health I-ORG Research I-ORG Institute I-ORG NHRI-EX112-11224EI O of O Taiwan O National B-ORG Cheng I-ORG Kung I-ORG University I-ORG NCKUH-10406014 O Kaohsiung B-ORG Municipal I-ORG Ta-Tung I-ORG Hospital I-ORG KMTTH-111-R002 O and O KMTTH-DK(A)112001 B-AWARD Kaohsiung B-ORG Medical I-ORG University I-ORG NPUST O KMU-111-P005 O KMU-TC111A02-1 B-AWARD KMU-DK(A)110003 B-AWARD and O KMU-DK(B B-AWARD 110002 O and O the O Minister B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Taiwan I-ORG MOST O 106-2314-B-006-066 O 108-2314-B-006-062 B-AWARD 110-2314-B-006-037-MY3 B-AWARD 110-2314-B-037-029-MY3 B-AWARD MOST111-2314-B-037-106 B-AWARD of O Taiwan O The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O by O an O Open B-ORG Project I-ORG of I-ORG the I-ORG Key I-ORG Laboratory I-ORG of I-ORG Grassland I-ORG Ecosystem I-ORG Gansu I-ORG Agricultural I-ORG University I-ORG Ministry I-ORG of I-ORG Education I-ORG KLGE202204 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32272566 O the O “Fuxi O Talent” O Plan O Gaufx-02J03 O of O Gansu O Agricultural O University O and O the O Industrial O Support O Program O Project O 2022CYZC-47 O of O Gansu B-ORG Provincial I-ORG Education I-ORG Department I-ORG This O work O was O supported O partly O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG no. O 2016YFC0905302 B-AWARD the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG nos O 81272698 B-AWARD 81672319 B-AWARD 81602507 B-AWARD the O capital B-ORG health I-ORG research I-ORG and I-ORG development I-ORG of I-ORG special I-ORG 2014-1-4022 O and O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Subject I-ORG no. O 2014CBA02002 B-AWARD The O funding O bodies O had O no O role O in O the O study O design O data O collection O or O analysis O decision O to O publish O or O manuscript O preparation O This O work O was O supported O by O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 O Program,2014CB542302 O CAMS O Innovation O Fund O for O Medical O Science O CIFMS O 2016-I2M-1-006 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81470541 O 81630014 B-AWARD 91531306 O 81500383 B-AWARD National O Basic O Research O Program O of O China O 973 O Program,2015CB554200 O Beijing O Municipal O Science O and O Technology O Commission O Z151100002115050 O Z151100004015176 O Beijing O Municipal O Commission O of O Education O KZ201610025028 O the O International O S&T O Cooperation O Program O of O China O 2013DFB30310 O and O the O AHA B-ORG Scientist I-ORG Development I-ORG Grant I-ORG L.C O 12SDG11680011 B-AWARD This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31500159 O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG of I-ORG Agriculture I-ORG Department I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 2016CXY-05 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 2016JQ3029 O and O Undergraduate B-ORG Innovation I-ORG Foundation I-ORG of I-ORG Northwest I-ORG A&F I-ORG University I-ORG 1201610712119 O This O study O was O supported O by O Beijing B-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospitals I-ORG Clinical I-ORG Medicine I-ORG Development I-ORG of I-ORG Special I-ORG Funding I-ORG Support I-ORG Grant O No. O ZYLX201412 B-AWARD Beijing B-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG Grant O No. O JJ2014-10 B-AWARD and O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O No.7154206 O This O work O has O received O financial O support O from O the O Spanish B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Innovation I-ORG CTQ2009-08490 O the O Xunta B-ORG de I-ORG Galicia I-ORG Centro O Singular I-AWARD de I-AWARD Investigación I-AWARD de I-AWARD Galicia I-AWARD Centro I-AWARD singular I-AWARD de I-AWARD investigación I-AWARD de I-AWARD Galicia I-AWARD accreditation I-AWARD 2019-2022 I-AWARD ED431G I-AWARD 2019/03 O Project B-AWARD CN2011/037 I-AWARD project I-AWARD ED431C I-AWARD 2018/04 I-AWARD and I-AWARD Project I-AWARD GRC2014/040 O the O Principado B-ORG de I-ORG Asturias I-ORG FICYT O IDI/2018/000181 O and O the O European O Union O European O Regional I-ORG Development I-ORG Fund-ERDF O Partial O financial O support O by O Arcelor O Mittal O R&D-Principado O de O Asturias O FUO-286-18 O Conicyt B-ORG research O fellowship O to O ML O PFCHA/Doctorado O Nacional/2018-21180427 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O no. O 81501595 B-AWARD Youth B-ORG Foundation I-ORG of I-ORG Zhongshan I-ORG Hospital I-ORG Grant O no. O 2015ZSQN09 B-AWARD Talent B-ORG Training I-ORG Program I-ORG Foundation I-ORG for I-ORG the I-ORG Excellent I-ORG Youth I-ORG Supported I-ORG by I-ORG Zhongshan I-ORG Hospital I-ORG Grant O no. O 2017ZSYQ24 B-AWARD Innovation B-ORG Fund I-ORG of I-ORG Zhongshan I-ORG Hospital I-ORG Grant O no. O 2017ZSCX05 B-AWARD Grant O 81771075 B-AWARD http://www.nsfc.gov.cn O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG and O Grant O BK20161565 B-AWARD http://kxjst.jiangsu.gov.cn O from O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG were O received O by O YS. O Grant O 2016NJMU052 B-AWARD http://www.njmu.edu.cn O from O Science B-ORG and I-ORG Technology I-ORG Development I-ORG Fund I-ORG of I-ORG Nanjing I-ORG Medical I-ORG University I-ORG was O received O by O WL. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the O Basic O Science O Research O Program O through O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O funded O by O the O Ministry O of O Education O NRF-2022 O R1F1A1074704 O Institute B-ORG of I-ORG Information I-ORG I-ORG communications I-ORG Technology I-ORG Planning I-ORG I-ORG Evaluation I-ORG IITP O grant O funded O by O the O Korea O government O MSIT O No. O 2022-0-00218 B-AWARD the O MSIT B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG ICT I-ORG Korea O under O the O Innovative O Human O Resource O Development O for O Local O Intellectualization O support O program O IITP-2022-RS-2022-00156360 O supervised O by O the O IITP O Institute O for O Information O O communications O Technology O Planning O O Evaluation O Korea B-ORG Institute I-ORG for I-ORG Advancement I-ORG of I-ORG Technology I-ORG KIAT O grant O funded O by O the O Korea O Government O MOTIE O N000P0017033 O and O N000P0017123 O This O work O was O supported O by O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2016YFA0400904 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grants O 21725505 B-AWARD and I-AWARD 21675145 O and O the O Science B-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Zhejiang I-ORG Province I-ORG GF18H180002 O This O research O was O funded O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG China O grant O number O 2019YFB1600700 B-AWARD National O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 51878058 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province O 2019JZ-02 B-AWARD This O study O was O supported O by O grants O from O the B-ORG National I-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 863 I-ORG Program I-ORG No. O 2013AA102506 O the B-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31160469 I-AWARD 31360561 O the B-ORG Major I-ORG Projects I-ORG for I-ORG New I-ORG Varieties I-ORG of I-ORG Genetically I-ORG Modified I-ORG Organisms I-ORG No. O 2014ZX08008-002 O and O a B-ORG research I-ORG program I-ORG of I-ORG innovation I-ORG team I-ORG from I-ORG Inner I-ORG Mongolia I-ORG NMGIRT-A1601 O This O work O was O supported O by O Graduate O Resource O Allocation O Committee O Research O Grants O from O the O Biology B-ORG Graduate I-ORG Student I-ORG Association I-ORG of I-ORG University I-ORG of I-ORG New I-ORG Mexico I-ORG RE O Alfaro O 400 B-AWARD 2014 O 400 B-AWARD 2015 O and O Alvin O R. O and O Caroline O G. O Grove O Summer O Research O Scholarships O RE O Alfaro O 2000 B-AWARD 2015 O 2225 B-AWARD 2016 O through O the O Department B-ORG of I-ORG Biology I-ORG University I-ORG of I-ORG New I-ORG Mexico O The O unpublished O study O of O spigot O ontogeny O of O Phyxelida O tanganensis O by O Robin O Carlson O and O Charles O Griswold O was O funded O by O NSF B-ORG grant I-ORG BIR-9531307 B-AWARD There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O A O research O grant O for O the O Dutch O GIST O Registry O was O received O from O Novartis B-ORG 3017/13 O Pfizer B-ORG WI189378 O Bayer B-ORG 2013-MED-12005 O and O Deciphera O 4EE9EEC-7F19-484D-86A4-646CFE0950A5 O These O funding O sources O did O not O have O any O involvement O in O the O conduction O of O this O research O This O work O was O supported O by O the O grants O from O National B-ORG High I-ORG Technology I-ORG Development I-ORG Plan I-ORG of I-ORG China I-ORG 2013AA102501 O China B-ORG Agricultural I-ORG Technology I-ORG Research I-ORG System I-ORG for I-ORG Layer I-ORG CARS-41 O and O Programs B-ORG for I-ORG Changjiang I-ORG Scholars I-ORG and I-ORG Innovative I-ORG Research I-ORG in I-ORG University I-ORG IRT1191 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O DF O and O IMP O was O supported O by O the O Wellcome B-ORG Trust I-ORG 087899 O and O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG BB/L001748/1 O BC O by O EMBO O The O Isaac B-ORG Newton I-ORG Trust I-ORG 11.35(af O Trinity O College O University O of O Cambridge O and O the O Wellcome O Trust O 087899 O BF O by O the O School O of O Biological O and O Chemical O Sciences O Queen O Mary O University O of O London O BG O by O the O Meinig O Family O Cornell O National O Scholarship O IMP O by O the O School O of O Biological O and O Chemical O Sciences O Queen O Mary O University O of O London O Biotechnology O and O Biological O Sciences O Research O Council O BB/L001748/1 O and O the O Department O of O Zoology O and O University O of O Cambridge O This O work O was O supported O by O the O Swedish B-ORG Agency I-ORG for I-ORG Economic I-ORG and I-ORG Regional I-ORG Growth I-ORG Tillvaxtverket O -];European O Union’s I-ORG Horizon I-ORG 2020 I-ORG Research I-ORG and I-ORG Innovation I-ORG Programme O The O Mobility O for O Regional O Excellence-2020 O RUN O 2017-00771];Indonesia O Endowment I-ORG Fund I-ORG for I-ORG Education I-ORG LPDP O PRJ-293/LPDP/2015 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41506177 O Cultivation B-ORG Plan I-ORG for I-ORG Youth I-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovative I-ORG Talents I-ORG of I-ORG Liaoning I-ORG Province I-ORG 2015006 O a O research O project O granted O by O Liaoning B-ORG Department I-ORG of I-ORG Education I-ORG L2015087 O and O a O research O project O granted O by O Liaoning B-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2015203003 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82204416 O the O Wuhan B-ORG Municipal I-ORG Education I-ORG Bureau I-ORG Project I-ORG 2019003 O the O Scientific B-ORG Research I-ORG Project I-ORG Funding I-ORG of I-ORG Jianghan I-ORG University I-ORG 2021jczx-002 O 06210035 B-AWARD 08190006 B-AWARD the O Young B-ORG Elite I-ORG Scientists I-ORG Sponsorship I-ORG Program I-ORG by I-ORG CAST I-ORG 2021-QNRC2-B16 O This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2017YFD0501500 B-AWARD Shanxi B-ORG Province I-ORG Science I-ORG Foundation I-ORG for I-ORG Excellent I-ORG Youths I-ORG Grant O No. O 201801D211003 B-AWARD and O Graduate B-ORG Education I-ORG Innovation I-ORG Project I-ORG of I-ORG Shanxi I-ORG Province I-ORG Grant O No. O 2019BY065 B-AWARD Financial O support O personnel O all O have O a O certain O role O in O the O design O all O experiments O and O approved O the O final O manuscript O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61527807 O 81701644 I-AWARD and I-AWARD 61801311 O the O Beijing B-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospitals I-ORG Mission I-ORG Plan I-ORG SML20150101 O the O Beijing B-ORG Scholars I-ORG Program I-ORG (2015 O 160 O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 7172064 O 7162048 I-AWARD and I-AWARD 7182044 O the O Beijing B-ORG Municipal I-ORG Administration I-ORG of I-ORG Hospitals I-ORG PX2018001 O and I-AWARD QML20180103 O and O the O Beijing B-ORG Friendship I-ORG Hospital I-ORG Capital I-ORG Medical I-ORG University I-ORG YYZZ2017B01 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61535005 B-AWARD and O 61475069 B-AWARD National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Projects I-ORG No. O 2017YFC1403803 B-AWARD and O 2017YFA0303700 B-AWARD Shenzhen O Science O and O Technology O Research O Funding O No. O JCYJ20180307155025481 O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 14380160 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31722007 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0505400 O and O the O Fujian B-ORG Natural I-ORG Science I-ORG Funds I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG 2018J07003 O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 31700163 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China O grant O number O 2017YFD0100800 B-AWARD and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Yangzhou O grant O number O YZ2017100 B-AWARD This O research O was O funded O by O the O Key O Research O and O Development O Projects O in O Zhejiang O Province O “Industrialization O Model O Projects O on O Exploring O Functional O Components O and O Related O Products O from O Tea O Flowers O and O Fruits” O 2018C02012 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG “Processing O of O Tea O Products O Key O Technology O of O Quality O Control O during O Storage O and O Equipment O Development” O 2017YFD0400803 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O 31501474 O This O research O was O also O supported O by O NIH O grants O P20RR016477 B-AWARD from O the O National B-ORG Center I-ORG for I-ORG Research I-ORG Resources I-ORG and O P20GM103434 O from O the O National O Institute O for O General O Medical O Sciences O NIGMS O awarded O to O the O West O Virginia O IDeA O Network O of O Biomedical O Research O Excellence O This O study O was O also O supported O by O Grant O Number O P20GM104932 O from O NIGMS O a O component O of O the O National O Institutes O of O Health O NIH O and O its O contents O are O solely O the O responsibility O of O the O authors O and O do O not O necessarily O represent O the O official O view O of O NIGMS O or O NIH O This O study O was O also O supported O by O COBRE O grant O GM102488/RR032138 O ARIA O S10 O grant O RR020866 O FORTESSA O S10 O grant O OD016165 O and O INBRE O grant O GM103434 O Acknowledgments O This O work O was O supported O by O the O grants O of O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81703803 O 81720108033 B-AWARD and O 81703814 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017A030310464 O Department B-ORG of I-ORG Education I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2016KQNCX026 O and O Guangdong B-ORG Key I-ORG Laboratory I-ORG for I-ORG translational I-ORG Cancer I-ORG research I-ORG of I-ORG Chinese I-ORG Medicine I-ORG 2018B030322011 O This O research O was O supported O by O National B-ORG Nanotechnology I-ORG Center I-ORG grants O P1751389 B-AWARD and I-AWARD P1851699 O Thailand B-ORG Research I-ORG Fund I-ORG grant O DBG6180030 B-AWARD and O the O Center B-ORG of I-ORG Excellence I-ORG for I-ORG Innovation I-ORG in I-ORG Chemistry I-ORG Ministry I-ORG of I-ORG Higher I-ORG Education I-ORG Science I-ORG Research I-ORG and I-ORG Innovation I-ORG grant O RU.APD18/59-02 B-AWARD This O study O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31801406 O the O Youth B-ORG Talent I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG 2016R25R08E01 O the O Hangzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Guidance I-ORG program I-ORG 20163501Y79 O the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-16-S05 O and O the O Open B-ORG Project I-ORG of I-ORG Key I-ORG Laboratory I-ORG of I-ORG Hemp I-ORG Biology I-ORG and I-ORG Processing I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Agriculture I-ORG KL-IBFC-201904 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31500467 O 31570567 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2572017ET02 O and O The O First-class B-ORG scientific I-ORG research I-ORG and I-ORG innovation I-ORG project I-ORG of I-ORG forestry I-ORG engineering I-ORG 201818 O This O work O received O support O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No O 42107152 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No O LQ22D020001 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Ningbo I-ORG No O 202003N4140 B-AWARD This O research O was O funded O by O the O Diputación B-ORG Provincial I-ORG de I-ORG Cuenca I-ORG Spain I-ORG and I-ORG the I-ORG Fundação I-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo I-ORG FAPESP O n° I-AWARD 2020/13230-8 O and O São B-ORG Paulo I-ORG State I-ORG University/National I-ORG Council I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Development I-ORG PIBIC O n° I-AWARD 2020/1000 O DCZ O is O grateful O for O a O Researcher B-ORG Fellowship I-ORG from I-ORG CNPq I-ORG PQ-2 O Proc I-AWARD 303268/2021-2 O This O research O was O supported O by O the O specific O research O fund O of O The B-ORG Innovation I-ORG Platform I-ORG for I-ORG Academicians I-ORG of I-ORG Hainan I-ORG Province I-ORG YSPTZX202131 O the O Hainan B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 320MS056 O 321RC747 B-AWARD the O Scientific B-ORG Research I-ORG Foundation I-ORG of I-ORG Hainan I-ORG Tropical I-ORG Ocean I-ORG University I-ORG RHDRC202117 O and O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG Hainan I-ORG Province I-ORG 321CXTD1012 O AR O received O grant O number O APQ-00991-15 B-AWARD by O the O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG Minas I-ORG Gerais I-ORG FAPEMIG),http://www.fapemig.br O AR O received O grant O number O 310938/2017-1 B-AWARD by O the O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq),http://www.cnpq.br O MLF O received O grant O number O Finance O Code O 001 B-AWARD by O the O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG CAPES),https://www.capes.gov.br O This O study O was O partially O funded O by O Coordenação O de O Aperfeiçoamento O de O Pessoal O de O Nível O Superior O CAPES O Brasil O – O Finance O Code O 001 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81902709 O 81872344 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2018A0303130102 O 2018A030313887 O Guangdong O Province O Innovation O Team O Construction O Program O on O Modern O Agriculture O Industrial O technology O system O 2019KJ103 O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017A050506044 O Science O and O Technology O Planning O Project O of O Guangzhou O City O 201704030028 O Key O Program O for O Subject O Research O of O Guangzhou O University O of O Chinese O Medicine O XK2019002 O GDAS’ O Special O Project O of O Science O and O Technology O Development O 2019GDASYL-0105002 O and O High-level O Leading O Talent O Introduction O Program O of O GDAS O 2016GDASRC-0102 O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0501200 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31872464 O and O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O The O work O was O supported O by O the B-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG for I-ORG Rural I-ORG Development I-ORG of I-ORG the I-ORG Twelfth I-ORG Five-year-Plan I-ORG of I-ORG China I-ORG 2013BAD22B02 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31400284 O 41501418 B-AWARD Science B-ORG and I-ORG Technology I-ORG Service I-ORG Network I-ORG Initiative I-ORG KFJ-EW-STS-119 O KFJ-EW-STS-061 B-AWARD and O the B-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG 2013BAJ04B04 O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG under O Grant O 2017YFB0503601 B-AWARD to O JL; O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O 41671448 B-AWARD to O JL; O and O China B-ORG Scholarship I-ORG Council I-ORG CSC O under O Grant O 201706275018 B-AWARD to O JL. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Institute B-ORG for I-ORG Information I-ORG I-ORG Communications I-ORG Technology I-ORG Planning I-ORG I-ORG Evaluation I-ORG IITP O grant O funded O by O the O Korea O government O No. O 2017-0-00451 B-AWARD to O SWL O Development O of O BCI O based O Brain O and O Cognitive O Computing O Technology O for O Recognizing O User’s O Intentions O using O Deep O Learning O Defense B-ORG Acquisition I-ORG Program I-ORG Administration I-ORG DAPA I-ORG and I-ORG Agency I-ORG for I-ORG Defense I-ORG Development I-ORG ADD I-ORG of I-ORG Korea I-ORG 06-201-305-001 O to O SWL O A O Study O on O Human-Computer O Interaction O Technology O for O the O Pilot O Status O Recognition O and O grant O No. O 01-2015-0007 B-AWARD to O KSS O from O the O Seoul B-ORG National I-ORG University I-ORG Dental I-ORG Hospital I-ORG SNUDH O Research O Fund O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFA0205502 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61821002 I-AWARD 81571806 I-AWARD 81671820 O the O Science B-ORG and I-ORG Technology I-ORG Support I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O BE2017763 O and O the O Fundamental O Research O Funds O for O the O Central O Universities O The O funders O had O no O role O in O study O design O in O the O collection O analysis O and O interpretation O of O data O in O the O writing O the O manuscript O or O in O the O decision O to O submit O the O article O for O publication O This O work O was O funded O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG grant O number O 2017YFE0111100-04 B-AWARD 2019YFC0312605 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 41776163 B-AWARD 41876164 B-AWARD Major B-ORG Projects I-ORG on I-ORG the I-ORG Transformation I-ORG of I-ORG Old I-ORG and I-ORG Novel I-ORG Kinetic I-ORG Energy I-ORG of I-ORG Shandong I-ORG Province I-ORG 2020–1220 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG grant O number O ZR2019QD012 B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81430004 O 81770181 B-AWARD and O 81700163 B-AWARD National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG for I-ORG Precision I-ORG Medicine I-ORG 2017YFC0909800 O and O CAMS B-ORG Initiative I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG 2016-I2M-1-007 O The O work O was O collaboratively O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 41701448 B-AWARD and O 71874116 B-AWARD the O Applied O Basic O Research O Funded O Project O of O Sichuan O Science O and O Technology O Department O Grant O No. O 2020YJ0117 O Chengdu O Federation O of O Social O Science O Association O Grant O No. O ZZ05 O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Resources I-ORG and I-ORG Environmental I-ORG Information I-ORG System I-ORG Grant O No. O 201811 B-AWARD the O Humanities O and O Social O Sciences O Research O Fund O Project O of O Southwest O Petroleum O University O Grant O No. O 2019RW021 O and O Sichuan B-ORG University I-ORG Grant O Nos O 2018hhf-27 B-AWARD and O SKSYL201811 B-AWARD The O funders O had O no O part O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O study O was O supported O by O the O funds O of O Guangxi B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2013GXNSFBA019191 O Key B-ORG Laboratory I-ORG for I-ORG High-Incidence I-ORG Tumor I-ORG Prevention I-ORG and I-ORG Treatment I-ORG by I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG GKE2015-ZZ04 O Research B-ORG Projects I-ORG of I-ORG Department I-ORG of I-ORG Health I-ORG of I-ORG Guangxi I-ORG Zhuang I-ORG Autonomous I-ORG Region I-ORG Z2013424 O and O Sponsoring B-ORG Projects I-ORG of I-ORG Scientific I-ORG Research I-ORG for I-ORG Universities I-ORG in I-ORG Guangxi I-ORG LX2014064 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O preparation O of O the O manuscript O or O decision O to O publish O This O research O was O funded O by O Fundação B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG Tecnologia I-ORG FCT O through O the O PhD O grant O SFRH/BD/136609/2018 B-AWARD awarded O to O ACM O Vítor O the O research O contract O to O S.P.A O DL O 57/2016/CP1438/CT0008 O and O the O research O projects O PTDC/CAL-ZOO/29654/2017 B-AWARD and O UIDB/00276/2020 B-AWARD CIISA O and O LA/P/0059/2020 B-AWARD AL4AnimalS O This O research O was O funded O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China O grant O number O 2021YFD2100300 B-AWARD Key B-ORG R&D I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG China O grant O number O 2021CXGC010808 B-AWARD Open B-ORG Project I-ORG Program I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Food I-ORG Science I-ORG and I-ORG Technology I-ORG Jiangnan I-ORG University O grant O number O SKLF-ZZB-202113 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG China O grant O number O BK20221076 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O Number O 32201936 B-AWARD This O work O was O funded O by O 1. O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.31401851 O to O Zhang O CH) O http://www.nsfc.gov.cn O 2. O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No.BK20130700 O to O Zhang O CH) O http://www.jstd.gov.cn O and O 3. O the O earmarked O fund O of O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG No.CARS-31 O to O Ma O RJ) O http://119.253.58.231 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O made O possible O by O support O from O the O USAID B-ORG cooperative B-AWARD agreement I-AWARD number I-AWARD 674-A-00-10-00093-00 O MHK O was O supported O by O the O Fogarty B-ORG International I-ORG Center I-ORG of I-ORG the I-ORG National I-ORG Institutes I-ORG of I-ORG Health I-ORG under O award O number O K01 B-AWARD TW009644 O Data O analysis O was O provided O by O the O Design O and O Analysis O Core O of O the O Baylor-UT O Houston O Center O for O AIDS O Research O a O NIH O funded O program O numbered O P30-AI36211 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O No. O 81372738 B-AWARD Capital’s B-ORG Funds I-ORG for I-ORG Health I-ORG Improvement I-ORG and I-ORG Research I-ORG grant O No. O 2020-2-1024 B-AWARD Science B-ORG Foundation I-ORG of I-ORG Peking I-ORG University I-ORG Cancer I-ORG Hospital I-ORG grant O No. O 2020-20 B-AWARD This O work O was O partly O supported O by O grants O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFA0104500 O from O the O Ministry O of O Science O and O Technology O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81770189 B-AWARD O 81621001 B-AWARD 81530046 O 81670167 O Collaborative O Innovation O Center O of O Hematology O China O the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG of I-ORG China I-ORG Grant O No. O 2016B030230003 B-AWARD Peking B-ORG University I-ORG Clinical I-ORG Scientist I-ORG Program(BMU2019LCKXJ003 O the O Fundamental O Research O Funds O for O the O Central O Universities O and O the B-ORG project I-ORG of I-ORG health I-ORG collaborative I-ORG innovation I-ORG of I-ORG Guangzhou I-ORG city I-ORG no. O 201704020214 B-AWARD This O work O was O supported O by O JAAS B-ORG Exploratory I-ORG and I-ORG Disruptive I-ORG Innovation I-ORG Program I-ORG ZX(17)2015 O Jiangsu B-ORG Agriculture I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Fund I-ORG CX(14)2044 O and O Yancheng B-ORG Agriculture I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG YK2015019 O The O funding O bodies O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O funded O by O East B-ORG Cheshire I-ORG Hospice O UK O grant O number O 123959 B-AWARD Oakhaven B-ORG Hospice O UK O grant O number O 142065 B-AWARD East B-ORG Cheshire I-ORG Hospice@Home O UK O grant O number O 152706 B-AWARD and O the O University O of O Liverpool O University O of O Liverpool O Pump O Priming O Fund O University O of O Liverpool O Impact O Accelerator O Fund O No O funders O provided O any O role O in O the O design O of O the O study O or O in O the O collection O analysis O and O interpretation O of O data O This O research O was O supported O by O the O Major B-ORG Research I-ORG Plan I-ORG No. O 91751112 B-AWARD and O the O General O Programme O No. O 41573071 B-AWARD and O 41371257 B-AWARD of O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O the O Key O Research O Project O of O Frontier O Science O No. O QYZDJ-SSW-DQC015 B-AWARD of O the O Chinese B-ORG Academy I-ORG of I-ORG Sciences O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG Grant O no. O ZR2016DQ12 B-AWARD and O the O Young B-ORG Taishan I-ORG Scholars I-ORG Programme I-ORG No. O tsqn20161054 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O byMICINNprojects O AGL2011-28890 O to O Ana O Gómez O and O AGL2015-67477-C2-2-R O to O Mercedes O Blázquez O and O from O theGeneralitat O Valenciana(Prometeo O II/2014/051 B-AWARD to O Silvia O Zanuy O Paula O Medina O was O supported O by O a O grant O from O theUniversity O of I-ORG AntofagastaMECE2 O ANT0806 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31870345 O the O fellowship O to O Y.L.was O given O by O the O China B-ORG Scholarship I-ORG Council I-ORG 202104910381 O Y.C O was O supported O by O the O Knowledge O Innovation O Program O of O Wuhan-Shuguang O Project O and O H.L O was O supported O by O the O Youth O Innovation O Promotion O Association O of O the O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG 2019339 O This O work O was O financially O supported O by O the O Scientific B-ORG and I-ORG Technological I-ORG Developing I-ORG Scheme I-ORG of I-ORG Jilin I-ORG Province O under O grant O no. O 20220402012GH B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O under O grant O no. O U21A20323 B-AWARD the O Capital B-ORG Construction I-ORG Fund I-ORG within I-ORG the I-ORG Budget I-ORG of I-ORG Jilin I-ORG Province O no. O 2023C044-2 B-AWARD and O the O Major B-ORG science I-ORG and I-ORG technology I-ORG projects I-ORG of I-ORG Jilin I-ORG Province I-ORG and I-ORG Changchun I-ORG City O under O grant O no. O 20210301024GX B-AWARD This O work O was O granted O from O Key B-ORG Laboratory I-ORG of I-ORG Reproductive I-ORG Dysfunction I-ORG Diseases I-ORG and I-ORG Fertility I-ORG Remodelling I-ORG of I-ORG Liaoning I-ORG Province I-ORG 2018225107 O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Liaoning I-ORG Province I-ORG 2018225093 O and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2018YFC1002105 O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 32202115 B-AWARD the O Scientific B-ORG Research I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Polytechnic I-ORG University I-ORG No. O Xjky2022090 B-AWARD and O Xjky2022095 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG of I-ORG Wuhu I-ORG City I-ORG No. O 2022jc27 B-AWARD This O project O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31460523 O 31660588 I-AWARD 31660569 I-AWARD 31760600 O the O Open B-ORG Project I-ORG of I-ORG Qinghai I-ORG Key I-ORG Laboratory I-ORG of I-ORG Qinghai-Tibet I-ORG Plateau I-ORG Biological I-ORG Resources I-ORG 2017-ZJ-Y10 O and O the O Fundamental B-ORG Research I-ORG Program I-ORG of I-ORG Qinghai I-ORG 2016-ZJ-751 O 2017-ZJ-Y18 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the B-ORG sub-project I-ORG of I-ORG the I-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG 2021YFC2701002 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81801461 O 81873836 B-AWARD 81771594 O 81671474 B-AWARD 81501267 B-AWARD the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2019A1515012034 O the B-ORG Project I-ORG of I-ORG Guangzhou I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG 201607010341 O 202201020643 B-AWARD This O research O was O funded O by O the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG project I-ORG 2022YFD1200605 O the B-ORG Beijing I-ORG Innovation I-ORG Consortium I-ORG of I-ORG Agriculture I-ORG Research I-ORG System I-ORG BAIC03-01 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Project O ID: O 31961143010 B-AWARD 31970010 B-AWARD and O CAS B-ORG Engineering I-ORG Laboratory I-ORG for I-ORG Advanced I-ORG Microbial I-ORG Technology I-ORG of I-ORG Agriculture I-ORG KFJ-PTXM-016 O This O research O was O funded O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG grant O number O 2018YFE0201302 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 61873333 B-AWARD Key B-ORG research I-ORG and I-ORG development I-ORG plan I-ORG of I-ORG Shandong I-ORG Province I-ORG grant O numbers O 2019TSLH0301 B-AWARD 2019GHZ004 B-AWARD This O research O was O funded O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20160265 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51608520 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2016M590516 O National O Natural O Science O Foundation O of O China O 51734009 O and O Texas B-ORG Department I-ORG of I-ORG Transportation I-ORG 0-6783 O This O research O was O partially O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81970548 B-AWARD the O Wuhan B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG grant O number O 2019020701011485 B-AWARD and O the O Medical B-ORG Science I-ORG Advancement I-ORG Program I-ORG Clinical I-ORG Medicine I-ORG of I-ORG Wuhan I-ORG University I-ORG grant O number O TFLC B-AWARD 2018003 O This O research O received O no O external O funding O This O research O was O funded O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32070352 O Doctoral B-ORG Initiation I-ORG Project I-ORG of I-ORG Liaoning I-ORG Normal I-ORG University I-ORG 2021BSL003 O and O Educational B-ORG Department I-ORG of I-ORG Liaoning I-ORG Province I-ORG LJKMZ20221427 O This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 31802098 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG no. O 2662017PY051 B-AWARD and O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG no. O 2018M640715 B-AWARD This O work O was O supported O by O ANID-CHILE B-ORG Fondecyt I-ORG grant O No O 1180337 B-AWARD A.D.K O 2018–2022 O 1190334 B-AWARD S.Z O 2019–2023 O EQM190110 B-AWARD and O ACT210012 B-AWARD J.F.C O EQM150093 B-AWARD B.R.-J O and O 1221362 B-AWARD J.G O 2022–2025 O LysoMod O funded O by O the O European B-ORG Union’s I-ORG Horizon I-ORG 2020 I-ORG research I-ORG and I-ORG innovation I-ORG programme I-ORG RISE I-ORG under I-ORG the I-ORG Marie I-ORG Sklodowska-Curie I-ORG grant O agreement O No O 734825 B-AWARD S.Z O F.M.P O A.D.K O 2017–2022 O and O the O Mizutani B-ORG Foundation I-ORG for I-ORG Glycoscience O grant O No: O 200133 B-AWARD F.M.P O D.A.P O A.D.K O 2020 O F.M.P O is O a O Wolfson O Royal O Society O Merit O Award O Holder O and O a O Wellcome O Trust O Investigator O in O science O This O research O was O funded O by O the O Education B-ORG Department I-ORG of I-ORG Hainan I-ORG Province I-ORG No. O HnjgY2022-12 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 32260127 B-AWARD and O the O Hainan B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 320CXTD437 B-AWARD This O study O is O part O of O ‘u-loop’ O ocean O ridge O hydrothermal O vent O ecosystem O monitoring O and O conservation O project O financially O supported O by O China B-ORG Ocean I-ORG Mineral I-ORG Resource I-ORG R&D I-ORG Association I-ORG COMRA O DY135-E2-1-03 O and I-AWARD DY135-E2-1-02 O It O is O also O supported O by O Hong B-ORG Kong I-ORG Branch I-ORG of I-ORG South I-ORG Marine I-ORG Science I-ORG and I-ORG Engineering I-ORG Guangdong I-ORG Laboratory I-ORG SMSEGL20Sc01 O to O P.Y.-Q O the O Scientific B-ORG Research I-ORG Fund I-ORG of I-ORG the I-ORG Second I-ORG Institute I-ORG of I-ORG Oceanography O MNR O grant O no. O QNYC1902 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O no. O 2017YFC0306603 B-AWARD a O Japan B-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG Grant-in-Aid I-ORG for I-ORG Scientific I-ORG Research I-ORG 18K06401 O and O the O Hong B-ORG Kong I-ORG Research I-ORG Grants I-ORG Council I-ORG GRF O grant O no. O 16101219 B-AWARD This O study O was O funded O by O CAMS B-ORG Youth I-ORG Talent I-ORG Award I-ORG Project I-ORG No. O 2018RC320006 B-AWARD CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences O CIFMS O No. O 2016-I2M-1-002 B-AWARD and O Chinese B-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG Initiative I-ORG for I-ORG Innovative I-ORG Medicine I-ORG CAMS-2017-I2M-1-002 O This O work O was O supported O by O the O 333 B-ORG High-level I-ORG Talents I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O LGY2020032 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Changzhou I-ORG No. O CE20225040 B-AWARD and O Qingmiao B-ORG Talents I-ORG Cultivation I-ORG Project I-ORG of I-ORG Changzhou I-ORG Health I-ORG Commission I-ORG No. O CZQM2020089 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O Medical B-ORG University I-ORG of I-ORG Lublin I-ORG DS440/2018-2019 B-AWARD The B-ORG Polish I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Higher I-ORG Education I-ORG MNmb B-AWARD 510/2016-2017 I-AWARD and O Polish B-ORG National I-ORG Science I-ORG Centre I-ORG NCN O DEC-2015/17/B/NZ1/01777 B-AWARD and O DEC-2017/25/B/NZ4/02364 B-AWARD grants O This O work O was O supported O by O the O State B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG China I-ORG grant O no. O 2016YFB0301603 B-AWARD the B-ORG International I-ORG Corporation I-ORG of I-ORG S&T I-ORG Project I-ORG in I-ORG Xinjiang I-ORG Bingtuan I-ORG grant O no. O 2018BC003 B-AWARD and O the B-ORG International I-ORG Corporation I-ORG of I-ORG S&T I-ORG Project I-ORG in I-ORG Shihezi I-ORG University I-ORG grant O no. O GJHZ201701 B-AWARD This O work O was O supported O by O Hatch O Funds O from O the O North B-ORG Carolina I-ORG Agriculture I-ORG Experiment I-ORG Station I-ORG for I-ORG Project I-ORG NC02432 B-AWARD U.S B-ORG Department I-ORG of I-ORG Agriculture I-ORG CRIS I-ORG project I-ORG 5358-21000-046-00D B-AWARD and O National B-ORG Institutes I-ORG of I-ORG Food I-ORG and I-ORG Agriculture I-ORG grant O number O 2016-68004-24931 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2018YFC1900102 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 41501242 I-AWARD 51325804 O and O the O Major B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG for I-ORG Water I-ORG Pollution I-ORG Control I-ORG and I-ORG Treatment I-ORG No. O 2012ZX07203-003 O of O China O This O research O has O been O co-financed O by O the O European B-ORG Regional I-ORG Development I-ORG Fund I-ORG of I-ORG the I-ORG European I-ORG Union I-ORG and I-ORG Greek I-ORG national I-ORG funds I-ORG through O the O Operational B-AWARD Program I-AWARD Competitiveness O Entrepreneurship B-ORG and I-ORG Innovation I-ORG under I-ORG the I-ORG call I-ORG RESEARCH–CREATE– I-ORG INNOVATE I-ORG project O code O T1EDK-04200 B-AWARD MU-SA O This O work O was O supported O by O the O French B-ORG Embassy I-ORG in I-ORG Athens-Greece I-ORG with O the O program O “Programme B-AWARD de I-AWARD bourses I-AWARD pour I-AWARD séjour I-AWARD scientifique I-AWARD de I-AWARD haut I-AWARD niveau I-AWARD SSHN I-AWARD en I-AWARD France I-AWARD 2020–2021” I-AWARD This O work O was O mainly O supported O by O the O institute O fundings O of O Institute O for O Semiconductor O Technology O TU O Braunschweig O and O Fraunhofer O Institute O for O Surface O Engineering O and O Thin O Films O X.Wang O acknowledges O the O support O by O scholarship O from O the O China B-ORG Scholarship I-ORG Council I-ORG CSC O under O the O Grand O CSC O No. O 201206950015 B-AWARD This O work O was O partially O supported O by O General O Research O Fund O 612113 O from O Hong B-ORG Kong I-ORG Research I-ORG Grant I-ORG Council O ITS/362/14FP B-AWARD from O Hong B-ORG Kong I-ORG Innovation I-ORG Technology I-ORG Commission I-ORG This O research O was O funded O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31873016 O and O 31772757 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0500102 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG of O China O QC2016044 O and O YQ2019C031 B-AWARD This O work O was O supported O by O the O research O grants O of O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG Precision I-ORG Medicine I-ORG Initiative I-ORG of I-ORG China I-ORG 2016YFC0900803 O Scientific B-ORG Research I-ORG Foundation I-ORG of I-ORG Xinxiang I-ORG Medical I-ORG University I-ORG BSKYZZ201706 O 300/505233 O and O BSKYZZ201628 B-AWARD 300/505186 O Peak B-ORG Subject I-ORG Project I-ORG of I-ORG Public I-ORG Health I-ORG in I-ORG Xinxiang I-ORG Medical I-ORG University I-ORG GWGFXK2018008 O The O Foundation O and O Frontier O Technology O Research O Project O in O Henan O Province O 2300410191 O The O funding O sources O were O not O involved O in O the O study O design O data O collection O analysis O and O interpretation O or O in O writing O and O submitting O the O manuscript O This O research O was O funded O by O the O Henan B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project O grant O number O 221100110100 B-AWARD Henan B-ORG Provincial I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Project O grant O number O 222102110077 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Henan I-ORG Province O grant O number O 212300410015 B-AWARD the B-ORG Zhongyuan I-ORG Talent I-ORG Program O grant O number O ZYQR201912157 B-AWARD This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2016YFA0204300 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31700092 O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG for I-ORG Young I-ORG Scientists I-ORG of I-ORG China I-ORG Grant O No. O 21908101 B-AWARD 21576134 B-AWARD and O the B-ORG China I-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M642237 O This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG under O Grant O No. B-AWARD 2017YFD050080 O China B-ORG Agricultural I-ORG Research I-ORG System I-ORG under O Grant O No. B-AWARD CARS-42-17 O Special B-ORG Fund I-ORG for I-ORG Key I-ORG Laboratory I-ORG of I-ORG Animal I-ORG Disease I-ORG and I-ORG Human I-ORG Health I-ORG of I-ORG Sichuan I-ORG Province I-ORG under O Grant O No. B-AWARD 2016JPT0004 O Sichuan B-ORG Veterinary I-ORG Medicine I-ORG and I-ORG Drug I-ORG Innovation I-ORG Group I-ORG of I-ORG China I-ORG Agricultural I-ORG Research I-ORG System I-ORG CARS-SVDIP O This O work O was O funded O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31872604 O 31572658 O the B-ORG Earmarked I-ORG Fund I-ORG for I-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-45-15 O and O the B-ORG Major I-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG Project I-ORG of I-ORG Hubei I-ORG Province I-ORG 2015ABA045 O This O work O was O supported O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81672640 O the B-ORG Department I-ORG of I-ORG Education I-ORG Guangdong I-ORG Government I-ORG under I-ORG the I-ORG Top-tier I-ORG University I-ORG Development I-ORG Scheme I-ORG for I-ORG Research I-ORG and I-ORG Control I-ORG of I-ORG Infectious I-ORG Diseases I-ORG 2015045 O Sail B-ORG plan I-ORG training I-ORG high-level I-ORG personnel I-ORG project I-ORG of I-ORG Guangdong I-ORG Province I-ORG 174019 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2014A030313484 O and O Shantou B-ORG University I-ORG Medical I-ORG College I-ORG Clinical I-ORG Research I-ORG Enhancement I-ORG Initiative I-ORG 2014110109 O This O work O was O supported O in O part O by10.13039/100000002NIHgrants O HL071818 B-AWARD HL122416 B-AWARD and O CA221289 B-AWARD to O J.T O and O an10.13039/100000048American O Cancer I-ORG Society I-ORG – I-ORG Michigan I-ORG Cancer I-ORG Research I-ORG Fund I-ORG Postdoctoral I-ORG Fellowship(PF-14-224-01-DMC O to O J.C O This O research O used O resources O of O the O Advanced O Photon O Source O a O U.S O Department O of O Energy O DOE O Office O of O Science O User O Facility O operated O for O the O DOE O Office O of O Science O by10.13039/100006224Argonne O National I-ORG Laboratoryunder O Contract O No. O DE-AC02-06CH11357 B-AWARD Use O of O the O LS-CAT O Sector O 21 O was O supported O by O the10.13039/100004948Michigan O Economic I-ORG Development I-ORG Corporation I-ORG and I-ORG the I-ORG Michigan I-ORG Technology I-ORG Tri-Corridor(Grant O 085P1000817 B-AWARD This O research O used O the O DNA O Sequencing O Core O of O the O Michigan O Diabetes O Research O and O Training O Center O supported O by O DK20572 O The O Center O for O Structural O Biology O wherein O ITC O experiments O were O performed O by O Krishnapriya O Chinnaswamy O is O grateful O for O support O from O the O Life O Sciences O Institute O the O UM O Comprehensive O Cancer O Center O the O UM O Medical O School O Endowment O for O Basic O Sciences O and O grants O from O the O NIH O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31900294 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2022NSFSC1659 O and O the O Science B-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG of I-ORG Ya’an I-ORG 22SXHZ0048 O This O research O was O funded O by O the O European B-ORG Commission I-ORG under I-ORG the I-ORG framework I-ORG program I-ORG of I-ORG the I-ORG European I-ORG Union I-ORG grant O agreement O no. O 211696 B-AWARD LipiDiDiet O the O EU B-ORG Joint I-ORG Program–Neurodegenerative I-ORG Disease I-ORG Research I-ORG JPND I-ORG and I-ORG BMBF I-ORG grants O MIND-AD B-AWARD 01ED1509 O and O EURO-FINGERS B-ORG 01ED2003 O This O work O was O completed O as O part O of O the O MAPLE O project O Gut O and O Blood O Microbiomics O for O Studying O the O Effect O of O a O Polyphenol-Rich O Dietary O Pattern O on O Intestinal O Permeability O in O the O Elderly O supported O within O the O European O Joint O Programming O Initiative O “A O Healthy O Diet O for O a O Healthy O Life” O JPI O HDHL,http://www.healthydietforhealthylife.eu O granted O by O Mipaaft B-ORG Italy O D.M B-AWARD 8245/7303/2016 O MINECO B-ORG Spain O PCIN-2015-238 B-AWARD and O BBSRC O U.K O BB/R012512/1 B-AWARD Cristina O Andres-Lacueva O was O also O supported O by O grant O 2017SGR1546 O from O the O Generalitat O de O Catalunya’s O Agency O AGAUR O funds O from O CIBERFES O co-funded O by O the O FEDER O Program O from O the O European O Union O and O ICREA O Academia O Award O 201 O Additional O funding O was O provided O by O the O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG UK) O through O an O Institute O Strategic O Programme O Grant O ‘Food O Innovation O and O Health’ O Grant O No. O BB/R012512/1 O to O the O Quadram O Institute O Bioscience O Raúl O González-Domínguez O thanks O the O “Juan O de O la O Cierva” O program O from O MINECO O FJCI-2015-26590 O This O study O was O supported O by O grants-in-aid O from O the O following O funds O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0112500 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81770987 O 81700896 B-AWARD 81701306 O 81770988 O Shanghai B-ORG Sailing I-ORG Program I-ORG 17YF1414300 O Innovation B-ORG Program I-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Education I-ORG Commission I-ORG 2017-01-07-00-02-E00047 O multi-center B-ORG clinical I-ORG research I-ORG project I-ORG from I-ORG school I-ORG of I-ORG medicine I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG DLY201502 O and O Shanghai B-ORG Shen-Kang I-ORG Hospital I-ORG Management I-ORG Center I-ORG Project I-ORG SHDC12015101 O The O funding O bodies O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O The O AMPrEP O project O received O funding O as O part O of O the O H‐team O initiative O from O ZonMw B-ORG grant O number O 522002003 B-AWARD the O National O Institute O for O Public O Health O and O the O Environment O and O GGD O research O funds O The O study O drug O is O provided O by O Gilead B-ORG Sciences O The O H‐TEAM O initiative O is O being O supported O by O the O Aidsfonds O Netherlands O grant O number O 2013169 O Stichting O Amsterdam O Diner O Foundation O Gilead O Sciences O Europe O Ltd O grant O number O PA‐HIV‐PREP‐16‐0024 O Gilead O Sciences O protocol O numbers O CO‐NL‐276‐4222 B-AWARD CO‐US‐276‐1712 B-AWARD Janssen B-ORG Pharmaceuticals I-ORG reference O number O PHNL/JAN/0714/0005b/1912fde B-AWARD M.A.C O AIDS O Fund O and O ViiV B-ORG Healthcare I-ORG PO O numbers O 3000268822 B-AWARD 3000747780 B-AWARD This O study O was O supported O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0904800 O 2019YFC0840607 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81800831 O 81800799 O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG China I-ORG 2017ZX09304010 O and O Shanghai B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG 201740088 O The O sponsor O or O funding O organization O had O no O role O in O the O design O or O conduct O of O this O research O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O Grants O Nos O 32170019 B-AWARD and O 31670027 B-AWARD the O Open B-ORG Fund I-ORG Program I-ORG of I-ORG Engineering I-ORG and I-ORG Research I-ORG Center I-ORG for I-ORG Southwest I-ORG Bio-Pharmaceutical I-ORG Resources I-ORG of I-ORG National I-ORG Education I-ORG Ministry I-ORG of I-ORG China I-ORG Guizhou I-ORG University I-ORG No. O GZUKEY201606 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Foundation I-ORG of I-ORG Guizhou I-ORG Province I-ORG [2020]1Y058 O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2019YFD1000300 O the O Severo B-ORG Ochoa I-ORG Programme I-ORG for I-ORG Centers I-ORG of I-ORG Excellence I-ORG in O R&D O 2016–2010 O SEV-2015-0533 O Postdoctoral O Program O and O the O International B-ORG Postdoctoral I-ORG Exchange I-ORG Fellowship I-ORG program I-ORG from I-ORG the I-ORG China I-ORG Postdoctoral I-ORG Council I-ORG 20170053 O This O report O is O independent O research O funded O by O theNational O Institute I-ORG for I-ORG Health I-ORG ResearchPolicy O Research O Programme O Policy O Research O Unit O in O Behaviour O and O Health O PR-UN-0409-10109 O theMedical O Research I-ORG Council[Unit O Programme O number O MC_UU_12015/3 B-AWARD and O theBritish O Heart I-ORG Foundation[Intermediate O Basic O Science O Research O Fellowship O grant O FS/12/58/29709 B-AWARD to O KW O The O views O expressed O in O this O publication O are O those O of O the O authors O and O not O necessarily O those O of O the O NHS O the O National O Institute O for O Health O Research O the O Department O of O Health O and O Social O Care O or O its O arm's O length O bodies O and O other O Government O Departments O the O Medical O Research O Council O or O the O British O Heart O Foundation O The O final O version O of O the O report O and O ultimate O decision O to O submit O for O publication O was O determined O by O the O authors O This O research O was O funded O by O the O Conseil B-ORG Régional I-ORG Hauts I-ORG de I-ORG France I-ORG and I-ORG I-SITE I-ORG ULNE I-ORG grant O StartAIRR O INS-spect O DOS0085690/00 B-AWARD Société O d’Accéleration O du O Transfert O de O Technologie O SATT O Nord O grant O BETA O and O Ins-spect O the O National B-ORG Research I-ORG Agency I-ORG ANR-17-CE14-0034 O Institut O Pasteur O de O Lille O grant O CPER O CTRL O Melodie O Fondation B-ORG pour I-ORG la I-ORG Recherche I-ORG Médicale I-ORG grant O EQU202103012732 B-AWARD INSERM O Université O de O Lille O Métropole O Européenne O de O Lille O and O Société O Francophone O du O Diabète O This O study O was O supported O by O the O 1•3•5 B-ORG Project I-ORG for I-ORG Disciplines I-ORG of I-ORG Excellence I-ORG at I-ORG West I-ORG China I-ORG Hospital I-ORG of I-ORG Sichuan I-ORG University I-ORG 2019HXFH042 O the O Sichuan B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2020YFS0147 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31871157 O 81830001 B-AWARD These O funding O agencies O were O not O involved O in O designing O the O study O collecting O or O analyzing O the O data O writing O the O manuscript O or O making O decisions O related O to O publication O The O authors O were O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 11561033 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Province I-ORG in I-ORG China I-ORG 20132BAB211001,20151BAB201008 O and O the O Foundation B-ORG of I-ORG Education I-ORG Department I-ORG of I-ORG Jiangxi I-ORG GJJ160914 O GJJ170759 O GJJ161603 O GJJ170788 O of O China O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81774156 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20161573 O the O Major B-ORG Research I-ORG Plan I-ORG of I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Higher I-ORG Education I-ORG Institutions I-ORG of I-ORG Jiangsu I-ORG Province I-ORG 16KJA360002 O 17KJB360007 O Jiangsu O Provincial O 333 O High O Levels O Talents O Cultivation O Project O BRA2016427 O Jiangsu O Provincial O Six O Talent O Peaks O Project O YY-022 O the O Project O of O the O Priority O Academic O Program O Development O of O Jiangsu O Higher O Education O Institutions O PAPD O This O work O was O supported O by O the O Chinese B-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG CIFMS O 2016-I2M-3-022 O 2017-I2M-3-019 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 3332018117 O the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Tianjin O China O 18ZXXYSY00110 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Tianjin O China O 18JCQNJC09500 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81572744 O This O work O was O supported O by O The B-ORG National I-ORG Mega-Project I-ORG for I-ORG Infectious I-ORG Disease I-ORG 2018ZX10301408 O SC O The B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG program I-ORG of I-ORG China I-ORG 2016YFD0500307 O SC O The B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81772205 O SC O CAMS B-ORG innovation I-ORG fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG 2018-I2M-3-004 O 2016-I2M-2-002 B-AWARD XYL O and O 2017-I2M-1-012 O YXZ O and O Xiehe O Scholar O to O SC. O This O work O was O sponsored O by O Shanghai B-ORG Municipal I-ORG Key I-ORG Clinical I-ORG Specialty I-ORG shslczdzd02201 O Shanghai B-ORG Top-Priority I-ORG Clinical I-ORG Key I-ORG Disciplines I-ORG Construction I-ORG Project I-ORG 2017ZZ02013 O SJ O was O sponsored O by O Shanghai B-ORG Pujiang I-ORG Program I-ORG 16PJD012 O This O work O was O supported O by O Microsoft O Research O the O eHealth O program O the O Beijing B-ORG National I-ORG Science I-ORG Foundation I-ORG in I-ORG China I-ORG Grant O 4152033 B-AWARD the B-ORG Technology I-ORG and I-ORG Innovation I-ORG Commission I-ORG of I-ORG Shenzhen I-ORG in I-ORG China I-ORG Grant O shenfagai2016-627 B-AWARD Beijing O Young O Talent O Project O in O China O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG China I-ORG from I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Software I-ORG Development I-ORG Environment I-ORG in I-ORG Beihang I-ORG University I-ORG in I-ORG China I-ORG Grant O SKLSDE-2017ZX-08 B-AWARD This O work O is O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O grant O number O 81671707 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG under O grant O number O 2016A030311054 B-AWARD Research B-ORG Projects I-ORG of I-ORG Guangzhou I-ORG Science I-ORG Technology I-ORG and I-ORG Innovation I-ORG Commission I-ORG under O grant O number O 201607010201 B-AWARD Research B-ORG Fund I-ORG for I-ORG Lin I-ORG He's I-ORG Academician I-ORG Workstation I-ORG of I-ORG New I-ORG Medicine I-ORG and I-ORG Clinical I-ORG Translation O and O the O Higher O Education O Colleges O and O Universities O Innovation O Strong O School O Project O under O grant O number O Q17024072 B-AWARD Financial O support O for O this O project O was O provided O by O research O Grant O from O Chinese B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O No. O 81661148057 B-AWARD a O Grant O from O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Acience I-ORG Foundation I-ORG of I-ORG China I-ORG LY16H200003 O a O Grant O from O Zhejiang B-ORG Provincial I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG China I-ORG 2017KY218 O a O Grant O from O the O Chongqing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG cstc2015jcyjA10003 O a O grant O from O the O Chongqing B-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG China I-ORG 2013-2-216 O This O work O was O supported O in O part O by O the B-ORG National I-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Program O 863 O Grant O No. O 2013AA020104 B-AWARD the O Foundation O for O Innovative O Research O Groups O of O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81621001 O the O National O Natural O Science O Foundation O of O China O Grant O No. O 81470342 B-AWARD and O the B-ORG Key I-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81230013 B-AWARD This O research O was O funded O by O The O National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O No.81970545 O No.82170609 O No.82170592 O No.81700554 O Natural O Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG Major O Project O grant O number O No.ZR2020KH006 O Ji’nan O Science I-ORG and I-ORG Technology I-ORG Development I-ORG Project O grant O number O No.2020190790 O Medical O Science I-ORG and I-ORG technology I-ORG development I-ORG Foundation I-ORG Nanjing I-ORG Department I-ORG of I-ORG Health I-ORG Key O Project O grant O number O NO.YKK20065 O The O Nanjing I-ORG Municipal I-ORG Administration I-ORG of I-ORG Health I-ORG and I-ORG Human I-ORG Services O grant O number O NO.YKK17061 O The O Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG Central I-ORG Universities O grant O number O NO.021414380323 O and O The O Research I-ORG and I-ORG Practice I-ORG Innovation I-ORG Project I-ORG of I-ORG Nanjing I-ORG University O grant O number O No.CX10284 O This O paper O got O its O funding O from O project O NRMSSHR-2022-Z08 B-AWARD supported O by O the O Key B-ORG Laboratory I-ORG of I-ORG Natural I-ORG Resources I-ORG Monitoring I-ORG and I-ORG Supervision I-ORG in I-ORG Southern I-ORG Hilly I-ORG Region O Ministry B-ORG of I-ORG Natural I-ORG Resources I-ORG Hunan I-ORG Provincial I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2022SK2082 O projects O 42277175 B-AWARD and O 52104110 B-AWARD supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O and O the O Science B-ORG and I-ORG Technology I-ORG Progress I-ORG and I-ORG Innovation I-ORG Plan I-ORG of I-ORG Hunan I-ORG Provincial I-ORG Department I-ORG of I-ORG Transportation I-ORG 201003 O and O 202120 B-AWARD The O authors O wish O to O acknowledge O this O support O This O work O was O supported O by O the O grants O from O the O Science B-ORG and I-ORG Technology I-ORG Development I-ORG Fund I-ORG Macau I-ORG SAR I-ORG File O No. O 0096/2019/A2 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O No. O 81470170 B-AWARD the O Research B-ORG Committee I-ORG of I-ORG the I-ORG University I-ORG of I-ORG Macau I-ORG MYRG2017-00178-ICMS O and O MYRG2018-00043-ICMS B-AWARD and O the O international B-ORG Cooperation I-ORG Department I-ORG of I-ORG National I-ORG Administration I-ORG of I-ORG traditional I-ORG Chinese I-ORG Medicine I-ORG GZYYGJ2019042 O This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32072723 O and O the O Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG 2022JDTD0030 O and O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Southwest I-ORG Minzu I-ORG University I-ORG 2021057 O This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG of I-ORG China I-ORG 2016YFD0501207 O the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-35 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG TD2019C001 O This O work O was O supported O by O Natural B-ORG Science I-ORG Research I-ORG Projects I-ORG of I-ORG Universities I-ORG of I-ORG Anhui I-ORG Province I-ORG KJ2019A0308 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81702495 O and O Anhui B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 1808085QH279 O The O funding O bodies O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O National B-ORG Social I-ORG Science I-ORG Foundation I-ORG General I-ORG Project O “Research O on O Optimization O and O Implementation O Path O of O National O Audit O Accountability O Mechanism O Based O on O the O Perspective O of O Corruption O Governance” O 18BZZ062 O Anhui B-ORG Province I-ORG Humanities I-ORG and I-ORG Social I-ORG Science I-ORG Key I-ORG Projects I-ORG SK2021A0424 O Key B-ORG Projects I-ORG of I-ORG Anhui I-ORG Provincial I-ORG Philosophy I-ORG and I-ORG Social I-ORG Science I-ORG Planning I-ORG AHSkZ2018D15 O and O Anhui B-ORG Provincial I-ORG Research I-ORG Program I-ORG “The I-ORG Impact I-ORG of I-ORG Corporate I-ORG Social I-ORG Responsibility I-ORG on I-ORG Low I-ORG Carbon I-ORG Innovation I-ORG Performance” I-ORG 2022AH051292 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81471482 O Children’s B-ORG Hospital I-ORG of I-ORG Fudan I-ORG University I-ORG Funding I-ORG EK1125180110 O EK112520180202 B-AWARD and O the O Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG 19411969900 O This O study O was O funded O by O the O General B-ORG Program I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. I-AWARD 81571603 O the B-ORG Major I-ORG Research I-ORG Plan I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG of I-ORG China I-ORG Grant O No.91542121 O the B-ORG Youth I-ORG Program I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No.81401363 O the B-ORG Capital I-ORG Health I-ORG Research I-ORG and I-ORG Development I-ORG of I-ORG Special I-ORG Programs I-ORG Grant O No. I-AWARD 2014-4-4062 O and O the B-ORG International I-ORG Cooperation I-ORG Project I-ORG from I-ORG State I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG Grant O No. I-AWARD 2014DFA31490 O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Number O 3167259 B-AWARD and O “Academic B-ORG Backbone” I-ORG Project I-ORG of I-ORG Northeast I-ORG Agricultural I-ORG University I-ORG Scholar I-ORG Program I-ORG Grant O Number O 18XG24 B-AWARD and O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG grant O number O 2017YFD0501105 B-AWARD This O study O was O supported O by O the O Special B-ORG Fund I-ORG for I-ORG Forest I-ORG Scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Welfare I-ORG 201504105 O the O Agricultural O Science O and O Technology O Independent O Innovation O Funds O of O Jiangsu O Province O CX(16)1005 O the O National O Key O Research O and O Development O Program O of O China O 2017YFD0600700 O the B-ORG Postgraduate I-ORG Research I-ORG I-ORG Practice I-ORG Innovation I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG KYCX18_0954 O and O the O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O The O funding O bodies O provided O the O financial O support O to O the O research O projects O experimental O costs O and O publication O fees O but O funder O didn’t O involve O in O the O experiment O design O data O analysis O or O preparation O of O manuscript O This O work O was O funded O by O the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0500600 O to O Xin O Yang O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.31402095 O to O Xin O Yang O the O National O Key O R&D O Program O of O China O 2017YFD0500500 O to O Xiaojun O Yang O and O the B-ORG Program I-ORG for I-ORG Shaanxi I-ORG Science I-ORG I-ORG Technology I-ORG 2017ZDXM-NY-087 O to O Xin O Yang O 2017TSCXL-NY-04-04 B-AWARD to O Xiaojun O Yang O This O work O was O supported O by O the O grant O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81200433 B-AWARD No. O 81360098 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Province I-ORG 20114BAB215020 O the B-ORG Young I-ORG Scientist I-ORG Training I-ORG Project I-ORG of I-ORG Jiangxi I-ORG Province I-ORG China I-ORG No. O 20153BCB23032 B-AWARD and O Jiangxi B-ORG Province I-ORG Graduate I-ORG Student I-ORG Innovation I-ORG Project I-ORG No. O YC2014-S094 B-AWARD This O research O was O funded O by O Jerome B-ORG Lejeune I-ORG Foundation I-ORG call O for O Grants O session O 2021a B-AWARD 2043 B-AWARD to O M.S O The O work O was O also O partially O supported O by O Lazio B-ORG Innova—Bandi I-ORG per I-ORG Gruppi I-ORG di I-ORG Ricerca I-ORG 2020 I-ORG AMETISTA I-ORG to O S.M O Prot O GeCoWEB O n. O A0375-2020 B-AWARD 36668 O CUP O F85F21003700009 B-AWARD and O the O Grant O of O Excellence O MIUR B-ORG ARTICOLO O 1, O COMMI B-AWARD 314–337 I-AWARD LEGGE I-AWARD 232/2016 O to O the O Department O of O Science O of O Roma O Tre O University O This O work O is O supported O by O National B-ORG High I-ORG Level I-ORG Hospital I-ORG Clinical I-ORG Research I-ORG Funding I-ORG 2022-PUMCH-A-127 O 2022-PUMCH-B-070 B-AWARD 2022-PUMCH-B-071 B-AWARD the O CAMS B-ORG Initiative I-ORG for I-ORG Innovative I-ORG Medicine I-ORG CAMS-I2M O 2017-I2M-3-001 B-AWARD and O the O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 7202160 O This O work O was O financially O supported O by O the B-ORG National I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 30772677 B-AWARD 81072562 B-AWARD the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 2012N06 B-AWARD and O the B-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG China I-ORG No. O 2012ZX09301002-001 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32122089 O U19A2041 B-AWARD 31972805 B-AWARD the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0900605 O 2019YFD0900200 B-AWARD and O the O Supported O by O the B-ORG earmarked I-ORG fund I-ORG for I-ORG CARS I-ORG CARS-45 O This O research O was O supported O in O part O by O the O National B-ORG Key I-ORG Research I-ORG I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018ZX10101002 O 2017YFD0500304 B-AWARD and O 2016YFC1202002 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81560338 O and O U1503283 B-AWARD State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Veterinary I-ORG Etiological I-ORG Biology I-ORG SKLVEB2017KEKT009 O and O International B-ORG Scientific I-ORG and I-ORG Technological I-ORG Cooperation I-ORG in I-ORG Bingtuan I-ORG 2016AH001 O This O study O was O supported O by O the O Project B-ORG of I-ORG Shanghai I-ORG Foundation I-ORG for I-ORG Senior I-ORG Citizens I-ORG S15027 O Construction B-ORG Project I-ORG of I-ORG Key I-ORG Discipline I-ORG of I-ORG Public I-ORG Health I-ORG in I-ORG Shanghai I-ORG 12GWZX1001 O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Pudong I-ORG New I-ORG Area I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG PW2015C-25 O Shanghai B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Key I-ORG Developing I-ORG Disciplines I-ORG 2015ZB0601 O This O work O was O supported O by O 1) O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O China O Grant O No. I-AWARD 2016A030310151 O 2) O Student B-ORG Innovation I-ORG Training I-ORG Program I-ORG of I-ORG Sun I-ORG Yat-Sen I-ORG University I-ORG Grant O No. I-AWARD 201901097 O 3) O Special B-ORG Funds I-ORG for I-ORG the I-ORG Cultivation I-ORG of I-ORG Guangdong I-ORG College I-ORG Students’ I-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG “Climbing O Program” O Special O Funds O pdjh2019a0004 B-AWARD and O 4) O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Youth O Science O fund O Grant O No. I-AWARD 81701416 O This O work O was O supported O by O grants O 81300687 B-AWARD from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O CJ20140061 B-AWARD from O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Changzhou O CJ20180044 B-AWARD from O the O Applied B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG Changzhou O ZD201512 B-AWARD from O the O Major B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Changzhou I-ORG Health I-ORG and I-ORG Family I-ORG planning I-ORG commission O and O BE2016659 B-AWARD from O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2022YFC3801000 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 52278378 B-AWARD No. O 51978630 B-AWARD No. O 52208375 B-AWARD the O Postdoctoral B-ORG Research I-ORG Foundation I-ORG of I-ORG China I-ORG 2022M722883 O 2022TQ0305 B-AWARD the O Program B-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Talents I-ORG in I-ORG Universities I-ORG of I-ORG Henan I-ORG Province I-ORG No. O 19HASTIT043 B-AWARD the O Program B-ORG for I-ORG Guangdong I-ORG Introducing I-ORG Innovative I-ORG and I-ORG Enterpreneurial I-ORG Teams I-ORG No. O 2016ZT06N340 B-AWARD for O which O the O authors O are O grateful O This O work O was O supported O in O part O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31671476 O and O 81472607 B-AWARD to O S.L O 31860311 B-AWARD to O Q. O L O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Province O China O 20171ACB20028 O to O S.L O and O the O Graduate B-ORG Innovation I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Province I-ORG China I-ORG YC2017-B019 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81673249 O Qing B-ORG Lan I-ORG Project I-ORG 2014 O Social B-ORG Development I-ORG Project I-ORG of I-ORG Zhenjiang I-ORG SH2016048 O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O and O Medical B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Foundation I-ORG Jiangsu I-ORG Province I-ORG Department I-ORG of I-ORG Health I-ORG Y201313 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O study O has O been O partly O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFC1306700 B-AWARD Zhijun O Zhang O the O National B-ORG Natural I-ORG Science I-ORG Key I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81830040 B-AWARD Zhijun O Zhang O Jiangsu B-ORG Provincial I-ORG Medical I-ORG Outstanding I-ORG Talent I-ORG No. O JCRCA2016006 B-AWARD Zhijun O Zhang O and O Scientific O Research O Program O of O Jiangsu B-ORG Provincial I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG No. O H2017007 B-AWARD Baoyu O Yuan O The O funding O body O did O not O contribute O to O the O design O of O the O study O or O the O collection O analysis O or O interpretation O of O data O or O in O writing O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 11574165 B-AWARD the O PCSIRT O Program O for I-ORG Changjiang I-ORG Scholars I-ORG and I-ORG Innovative I-ORG Research I-ORG Team I-ORG in I-ORG University O no. O IRT_13R29 B-AWARD the O 111 B-ORG Project I-ORG no. O B07013 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Financial O support O was O provided O by O CONICYT B-ORG Grant O N° B-AWARD 21140959 I-AWARD DNL O FONDECYT B-ORG N° B-AWARD 1040425 I-AWARD PAC O 1190529 B-AWARD Nelson O Valdivia O 1160370 B-AWARD SAE O and O to O the O Center B-ORG of I-ORG Applied I-ORG Ecology I-ORG and I-ORG Sustainability I-ORG CAPES I-ORG CONICYT I-ORG PIA/BASAL I-ORG FB0002 B-AWARD SAE O Nelson O Valdivia O was O supported O by O FONDAP B-ORG IDEAL I-ORG grant O N° B-AWARD 15150003 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O study O was O supported O by O the O US O National B-ORG Institutes I-ORG of I-ORG Health I-ORG R21MH100939 O the O Indian B-ORG Council I-ORG of I-ORG Medical I-ORG Research I-ORG HIV/INDOUS/152/9/2012-ECD-II O and O the O ITRA O project O funded O by O DEITy B-ORG India I-ORG Ref O No. O ITRA/15(57)/Mobile/HumanSense/01 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31770225 O the O Henan B-ORG Agricultural I-ORG University I-ORG Science I-ORG I-ORG Technology I-ORG Innovation I-ORG Fund I-ORG KJCX2016A2 O the O Funding B-ORG Scheme I-ORG of I-ORG Young I-ORG Backbone I-ORG Teachers I-ORG of I-ORG Higher I-ORG Education I-ORG Institutions I-ORG in I-ORG Henan I-ORG Province I-ORG 2015GGJS-081 O and O the O Key B-ORG Scientific I-ORG Research I-ORG Projects I-ORG of I-ORG Henan I-ORG Higher I-ORG School I-ORG 16A220002 O This O work O was O supported O by O the O grants O from O the B-ORG 13th I-ORG Five-year I-ORG National I-ORG Major I-ORG Project I-ORG 2016YFD0101107 O the B-ORG Ecology I-ORG Key I-ORG Discipline I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG 0713 I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 3147430 O 31500200 B-AWARD the B-ORG Excellent I-ORG Youth I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG Educational I-ORG Committee I-ORG 17B165 O and O Cooperative B-ORG Innovation I-ORG Center I-ORG of I-ORG Engineering I-ORG and I-ORG New I-ORG Products I-ORG for I-ORG Developmental I-ORG Biology I-ORG of I-ORG Hunan I-ORG Province I-ORG 20134486 O The O funding O bodies O had O no O involvement O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O funded O by O the O European B-ORG Regional I-ORG Development I-ORG Fund I-ORG ERDF I-ORG through I-ORG INTERREG I-ORG Atlantic I-ORG Area I-ORG Programme O under O the O scope O of O BLUEHUMAN O project O EAPA_151/2016 O and O through O COMPETE2020/PT2020 B-AWARD under O the O scope O of O research O project O SharTech B-ORG Ref O 028615 B-AWARD which O also O received O funding O from O the O Portuguese B-ORG Foundation I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG FCT O FCT O was O also O responsible O for O the O financial O support O of O the O investigator O contract O of O C.F.M O CEECIND/04687/2017 O and O PhD B-ORG scholarship I-ORG of I-ORG A.L.A I-ORG PD/BD/127995/2016 O This O work O was O supported O by O grants O from O the O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG grant O no. O 2012CB524906 B-AWARD to O X. O Gao O the O Shanghai B-ORG Municipal I-ORG Health I-ORG Project I-ORG Grant I-ORG grant O no. O 2013ZYJB0802 B-AWARD to O X. O Gao O the O Shanghai B-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG Foundation I-ORG Grant O Nos O 12GWZX0103 B-AWARD and I-AWARD 2013SY005 I-AWARD to O X. O Gao O the O National B-ORG Ministry I-ORG of I-ORG Education I-ORG Program I-ORG Grant O No. O 985III-YFX0302 B-AWARD to O X. O Gao O the O Shanghai B-ORG Hospital I-ORG Development I-ORG Center I-ORG Foundation I-ORG SHDC12012201 O to O X. O Gao O This O research O was O supported O by O the O National B-ORG Institute I-ORG on I-ORG Drug I-ORG Abuse I-ORG R34DA030311 O the O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health I-ORG T32MH109205 O the O UCLA B-ORG Center I-ORG for I-ORG HIV I-ORG Identification I-ORG Prevention I-ORG and I-ORG Treatment I-ORG Services I-ORG P30MH58107 O the O UCLA B-ORG Center I-ORG for I-ORG AIDS I-ORG Research I-ORG P30AI028697 O the O UCLA B-ORG Clinical I-ORG and I-ORG Translational I-ORG Science I-ORG Institute I-ORG UL1TR000124 O National O Institute O on O Drug O Abuse O R01DA038675 O Funders O had O no O role O in O the O design O of O the O study O nor O in O the O collection O analysis O and O interpretation O of O data O or O the O preparation O of O the O manuscript O This O work O was O co-financed O by O the O Southeast B-ORG Asia I-ORG Biodiversity I-ORG Research I-ORG Institute I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG grant O number O Y4ZK111B01 B-AWARD by O a O project O of O the B-ORG Lancang-Mekong I-ORG Cooperation I-ORG LMC I-ORG Special I-ORG Fund I-ORG Biodiversity O Monitoring O and O Network O Construction O along O Lancang-Mekong O River O Basin O project O No. O Y8GK041B01 B-AWARD the B-ORG CAS I-ORG 135 I-ORG program I-ORG No. O 2017XTBG-F03 B-AWARD and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 32000251 B-AWARD The O authors O gratefully O acknowledge O the O financial O support O of O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51804090 O 51971086 B-AWARD Opening B-ORG Project I-ORG of I-ORG the I-ORG Key I-ORG Laboratory I-ORG of I-ORG Advanced I-ORG Manufacturing I-ORG and I-ORG Intelligent I-ORG Technology I-ORG Ministry I-ORG of I-ORG Education I-ORG Harbin I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG KFKT202203 O The B-ORG University I-ORG Nursing I-ORG Program I-ORG for I-ORG Young I-ORG Scholars I-ORG with I-ORG Creative I-ORG Talents I-ORG in I-ORG Heilongjiang I-ORG Province I-ORG UNPYSCT-2020184 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG E2018045 O and O the O “hundred B-ORG thousand I-ORG and I-ORG ten I-ORG thousand” I-ORG Engineering I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Special I-ORG Project I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG 2019ZX10A01 O This O work O was O supported O by O thefoundation O of I-ORG National I-ORG Key I-ORG Program I-ORG of I-ORG Research I-ORG and I-ORG Development I-ORG of I-ORG China(Grant O No. O 2016YFC0900803),Bill B-AWARD I-ORG Melinda I-ORG Gates I-ORG Foundation(Grant O No. O OOP1148464),National B-AWARD Natural I-ORG Science I-ORG Funding I-ORG of I-ORG China(Grant O No. O 81903279 B-AWARD and O theNatural O Science I-ORG Fund I-ORG of I-ORG Hubei I-ORG Province(Grant O No. O 2018CFB634 B-AWARD Dr O Guo O is O supported O byCareer O Development I-ORG FellowshipAPP1107107 O from O the O Australian O National O Health O and O Medical O Research O Council O NHMRC O Dr O Li O is O supported O byEarly O Career I-ORG FellowshipAPP1109193 O from O the O Australian O NHMRC O This O work O was O supported O by O the O Research B-ORG and I-ORG Technology I-ORG Innovation I-ORG Fund I-ORG of I-ORG Hungary I-ORG K_124881 O to O DS, O FIEK_16-1-2016-0005 B-AWARD to O DS O and O GS, O PD_121381 B-AWARD to O BS, O KTIA_NAP_13-2014-0021 B-AWARD and O NAP2-2017-1.2.1-NKP-0002 B-AWARD to O ZS) O and O the O Breast B-ORG Cancer I-ORG Research I-ORG Foundation I-ORG BCRF-18-137 O to O ALR O BCRF-18-159 B-AWARD to O ZS O STakeda O is O a O recipient O of O the O Core-to-Core B-AWARD Program I-AWARD of O JSPS B-ORG This O work O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 62101148 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangxi I-ORG 2020GXNSFBA297156 O 2021GXNSFBA220051 B-AWARD and O Guangxi B-ORG Innovation I-ORG Driven I-ORG Development I-ORG Project I-ORG Guike O AA19254003 O This O research O is O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 31872241 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2572017PZ14 O National O Key O Programme O of O Research O and O Development O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2016YFC0503200 O and O Biodiversity O Survey O Monitoring O and O Assessment O Project O of O Ministry O of O Ecology O and O Environment O China O 2019HB2096001006).The O funders O supported O the O charge O of O field O studies O 16S O rRNA O sequencing O and O metabolitics O analysis O The O UK O Medical B-ORG Research I-ORG Council I-ORG and O the O Wellcome B-ORG Trust I-ORG grant O 102215/2/13/2 B-AWARD and O the O University O of O Bristol O provide O core O support O for O ALSPAC O A O comprehensive O list O of O grant O funding O is O available O on O the O ALSPAC O website O This O research O was O specifically O funded O by O the O Medical O Research O Council O grant O MR/K002767/1 B-AWARD awarded O to O Santiago O Rodriguez O GWAS O data O were O generated O by O Sample O Logistics O and O Genotyping O Facilities O at O Wellcome O Sanger O Institute O and O LabCorp O Laboratory O Corporation O of O America O using O support O from O 23andMe O C.B O was O supported O by O Cancer B-ORG Research I-ORG UK I-ORG grant O C18281/A19169 B-AWARD and O by O the O MSc/PgDip/PgCert O Genomic O Medicine O program O at O the O University O of O Exeter O The O Integrative O Epidemiology O Unit O IEU O is O supported O by O the O Medical O Research O Council O and O the O University O of O Bristol O G0600705 O MC_UU_12013/19 O and O the O Integrative O Cancer O Epidemiology O Programme O is O supported O by O a O Cancer O Research O UK O program O grant O C18281/A19169 O The O work O in O M.J.B.’s O laboratory O is O supported O by O grants O from O the O US B-ORG Department I-ORG of I-ORG Energy I-ORG Office I-ORG of I-ORG Biological I-ORG and I-ORG Environmental I-ORG Research I-ORG and I-ORG Low I-ORG Dose I-ORG Scientific I-ORG Focus I-ORG Area I-ORG DE-AC02-05CH1123 O by O National B-ORG Cancer I-ORG Institute I-ORG R37CA064786 O R01CA057621 B-AWARD R01CA140663 B-AWARD U54CA112970 B-AWARD U01CA143233 B-AWARD by O the O US B-ORG Department I-ORG of I-ORG Defense I-ORG W81XWH0810736 O The O mass O spectrometer O used O in O this O study O was O funded O by O the O shared O instrument O grant O NIH/NCRR O 1 B-AWARD S10 I-AWARD RR023680-1 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O project O was O support O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81730054 B-AWARD Grant O No.81873519 O the B-ORG Ministry I-ORG of I-ORG Health I-ORG of I-ORG P.R I-ORG China I-ORG Grant O No. O 201002012 B-AWARD and O Research B-ORG Project I-ORG of I-ORG PLA I-ORG Grant O No. O BLJ18J007 B-AWARD This O work O was O supported O by O the B-ORG National I-ORG Program I-ORG on I-ORG Key I-ORG Research I-ORG Project I-ORG of I-ORG China I-ORG 2018YFD0500801 O 2018YFD0500204 O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2662016PY003 O the O Technology O Base O and O Talents O Special O Program O of O Guangxi O Province O 2018AD09007 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG 2019CFA010 O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31672199 O and I-AWARD 31801902 O the O China B-ORG Earmarked I-ORG Fund I-ORG for I-ORG Modern I-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG CARS-23-B12 O and O Jiangsu B-ORG Province I-ORG Scientific I-ORG and I-ORG Technological I-ORG Achievements I-ORG into I-ORG Special I-ORG Fund I-ORG BE2017701 O The O supporters O did O not O play O any O role O in O the O design O collection O analysis O interpretation O of O the O relevant O data O or O in O writing O the O manuscript O This O work O was O supported O by O grants O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81400160 I-AWARD and O No. B-AWARD 82070218 O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG 2022J02036 O and O Sailing B-ORG Fund I-ORG of I-ORG Fujian I-ORG Medical I-ORG University I-ORG 2019QH1070 O and O 2021QH2041 B-AWARD This O research O was O supported O by O Deutsche B-ORG Forschungsgemeinschaft I-ORG grants O MA B-AWARD 1289/11-1 I-AWARD MU I-AWARD 1477/10-1 I-AWARD MI I-AWARD 2143/21 I-AWARD EI I-AWARD 423/4-1 O Johannes O und O Frieda O Marohn-Stiftung O grant O Alz/Iko-Hahn/2019 O Bayerische B-ORG Forschungsstiftung I-ORG grant O DeeP-CMV/AP-5/MM B-AWARD Deutscher B-ORG Akademischer I-ORG Austauschdienst I-ORG grants O Kicuntod/91686964 B-AWARD DAAD-Go8/2017-18/MM-WDR B-AWARD This O research O was O funded O by O the O National O Key I-ORG R&D I-ORG Program I-ORG of I-ORG China O under O Grant O number O 2018YFC1602206 B-AWARD Yangjiang O Science I-ORG and I-ORG Technology I-ORG Program I-ORG key I-ORG projects O under O Grant O number O 2019010 B-AWARD Guangzhou O Science I-ORG and I-ORG Technology I-ORG Program I-ORG key I-ORG projects O under O Grant O number O 201803040006 B-AWARD and O Guangdong O Science I-ORG and I-ORG Technology I-ORG Program I-ORG key I-ORG projects O under O Grant O number O 2018B020207006 B-AWARD This O work O was O funded O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31572658 O the B-ORG Major I-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG Project I-ORG of I-ORG Hubei I-ORG Province I-ORG 2015ABA045 O and O the B-ORG Earmarked I-ORG Fund I-ORG for I-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-45-15 O This O work O was O financially O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81402111 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2015A030313031 O and O Medical B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG A2016435 O The O funders O have O no O role O in O the O study O design O and O data O collection O analysis O and O interpretation O as O well O as O manuscript O writing O This O work O was O supported O by O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG grant O number O BB/M009513/1 B-AWARD to O AOK O SC; O Kirkstall O Ltd O UK O to O SM, O LH; O Engineering B-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG EP/M506539/1 O and I-AWARD EPM508056/1 O to O SM, O LH; O Alan O O Kathie O Stross O Summer O Fellowship O to O LH; O Dr O Hadwen O Trust O to O LH; O Medical B-ORG Research I-ORG Council I-ORG Confidence O in O Concept O award O number O IF B-AWARD MC-PC_13069 O to O SC, O AOK O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O funding O provided O by O 1) O Special B-ORG Fund I-ORG for I-ORG Health I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG China I-ORG No. O 201202019 O 2) O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG CIFMS O No. O 2016-I2M-1-019 O 3) O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81401690 O and O 4) O PUMC B-ORG Foundation I-ORG for I-ORG Young I-ORG investigator I-ORG No.33320140040 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by: O 1) O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81670472 B-AWARD 81700502 I-AWARD 81800538 O 2) O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG grant O number O 19ZR1447700 B-AWARD 3) O the O Health B-ORG System I-ORG Innovation I-ORG Project I-ORG of I-ORG Shanghai I-ORG Putuo I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG grant O number O ptkwws2019001 B-AWARD 4) O WBN B-ORG Hepatology I-ORG Research I-ORG Fund I-ORG of I-ORG China I-ORG Hepatitis I-ORG Prevention I-ORG and I-ORG Treatment I-ORG Foundation I-ORG grant O number O CFHPC2019031 B-AWARD 5) O the O Yangfan B-ORG Project I-ORG of I-ORG Shanghai I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG grant O number O 18YF1420000);(6 B-AWARD Project B-ORG of I-ORG Shanghai I-ORG Health I-ORG Commission I-ORG grant O number O 2019469 B-AWARD The O research O leading O to O these O results O has O received O funding O from O the O Spanish B-ORG Ministry I-ORG of I-ORG Economy I-ORG and I-ORG Competitiveness I-ORG under O Grants O C080020-09 B-AWARD Cajal O Blue O Brain O Project O Spanish O partner O of O the O Blue O Brain O Project O initiative O from O EPFL O TIN2017-83132 O and O a O FPU O Grant O FPU19/04516 O to O Ivan O Velasco O as O well O as O from O the O European B-ORG Union’s I-ORG Horizon I-ORG 2020 I-ORG Framework I-ORG Programme I-ORG for I-ORG Research I-ORG and I-ORG Innovation I-ORG under O the O Specific O Grant O Agreements O No. O 785907 B-AWARD Human O Brain O Project O SGA2 O and O 945539 O Human O Brain O Project O SGA3 O the O Agencia B-ORG Estatal I-ORG de I-ORG Investigación I-ORG PID2019-108311GB-I00/AEI/10.13039/501100011033 O and O PID2019-106254RB-I00 B-AWARD and O the O Spanish B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Innovation I-ORG under O Grant O PID2020-113013RB-C21 B-AWARD The O UK O Medical O Research O Council O and O the O Wellcome B-ORG Trust I-ORG Grant O ref O 102215/2/13/2 B-AWARD and O the O University O of O Bristol O provide O core O support O for O ALSPAC O A O comprehensive O list O of O grants O funding O is O available O on O the O ALSPAC O website O http://www.bristol.ac.uk/alspac/external/documents/grant-acknowledgements.pdf O This O research O was O specifically O funded O by O Department B-ORG for I-ORG Education I-ORG and I-ORG Skills I-ORG Grant O ref O EOR/SBU/2002/121 B-AWARD and O the O Wellcome B-ORG Trust I-ORG and I-ORG MRC I-ORG Grant O ref O 092731 B-AWARD This O publication O is O the O work O of O the O authors O and O they O will O serve O as O guarantors O for O the O contents O of O this O paper O This O specific O research O project O did O not O receive O any O funding O This O study O was O supported O by O Enterprise B-ORG Estonia I-ORG grant O EU30020 B-AWARD Institutional B-ORG research I-ORG funding I-ORG IUT B-AWARD 8-1 O Horizon B-ORG 2020 I-ORG Project I-ORG SEARMET I-ORG 692299 B-AWARD and O the O Estonian B-ORG Research I-ORG Council I-ORG grant O PRG1665 B-AWARD This O work O was O supported O by O the O Science B-ORG and I-ORG Technology I-ORG Plan I-ORG Program I-ORG of I-ORG Guangzhou I-ORG No. O 201803040012 O the O Key B-ORG Area I-ORG R&D I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2019B020227005 O and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No.2017YFC1307603 O This O work O was O financially O supported O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 2018YFC1004401 O Key B-ORG Project I-ORG of I-ORG national I-ORG natural I-ORG science I-ORG foundation I-ORG of I-ORG China I-ORG 82030040 O and O Clinical B-ORG Medical I-ORG Science I-ORG and I-ORG Technology I-ORG Special I-ORG No.BE2018602 O This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Chongqing I-ORG No. O cstc2021jcyj-jqX0008 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Research I-ORG Project I-ORG of I-ORG Chongqing I-ORG Municipal I-ORG Education I-ORG Commission I-ORG KJQN201901146 O and O the O Special B-ORG key I-ORG project I-ORG of I-ORG technological I-ORG innovation I-ORG and I-ORG application I-ORG development I-ORG in I-ORG Chongqing I-ORG cstc2020jscx-dxwtBX0048 O This O work O was O finically O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 51873207 B-AWARD 51803006 I-AWARD 81701811 I-AWARD 51673190 I-AWARD and I-AWARD 81671804 O the O Development B-ORG and I-ORG Reform I-ORG Commission I-ORG of I-ORG Jilin I-ORG Province I-ORG Grant O No. O 2018C052-4 B-AWARD the O Health B-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG Jilin I-ORG Province I-ORG Grant O No. O 20165061 B-AWARD the O Science O and O Technology O Development O Project O of O Jilin O Province O Grant O No. O 20190201068JC B-AWARD the O Youth O Talents O Promotion O Project O of O Jilin O Province O Grant O No. O 181909 B-AWARD the O Youth B-ORG Innovation I-ORG Promotion I-ORG Association I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences O Grant O No. O 2019005 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG Grant O No. O ZR2018BH008 B-AWARD This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81500490 O Application B-ORG Research I-ORG of I-ORG Capital I-ORG Clinical I-ORG Character I-ORG Z151100004015215 O and O Annual B-ORG Project I-ORG of I-ORG Air I-ORG Force I-ORG General I-ORG Hospital I-ORG KZ2015026 O and O KZ2016021 B-AWARD This O study O was O financially O supported O by O the O Jiangsu B-ORG Provincial I-ORG Key I-ORG Project I-ORG BE2018657 O the B-ORG Jiangsu I-ORG Medical I-ORG Innovation I-ORG Team I-ORG No. O CXDT-37 O and O the O Suzhou B-ORG Introduced I-ORG Project I-ORG of I-ORG Clinical I-ORG Medical I-ORG Expert I-ORG Team I-ORG SZYJTD201804 O This O study O was O supported O by O grants O from O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFD0500305 B-AWARD and O No. O 2017YFD0500301 B-AWARD Military B-ORG logistics I-ORG Research I-ORG Project I-ORG NO. O CWH17C017 B-AWARD Guangdong B-ORG Provincial I-ORG S&T I-ORG Project I-ORG No.2014A020214003 O the B-ORG Innovative I-ORG R&D I-ORG Team I-ORG Introduction I-ORG Program I-ORG of I-ORG Guangdong I-ORG No. O 2014ZT05S123 B-AWARD and O Research B-ORG initiative I-ORG Project I-ORG of I-ORG SMU I-ORG CX2017N007 O This O study O was O supported O by O the O project O CGL2010-16902 B-AWARD of O the O Spanish B-ORG Ministry I-ORG of I-ORG Research I-ORG and I-ORG Innovation O the O project O CGL2013-46026-P B-AWARD of O Ministerio B-ORG de I-ORG Economía I-ORG Industria I-ORG y I-ORG Competitividad O and O the O excellence O project O RNM B-AWARD 2300 I-AWARD of O the O Junta B-ORG de I-ORG Andalucía I-ORG and I-ORG the I-ORG Formación I-ORG de I-ORG Profesorado I-ORG Universitario I-ORG fellowship I-ORG AP2010-5373 B-AWARD from O the O Spanish B-ORG Ministry I-ORG of I-ORG Education O Luciano O M. O Verdade O has O a O productivity O scholarship O from O Ministério B-ORG da I-ORG Ciência I-ORG Tecnologia I-ORG Inovações I-ORG e I-ORG Comunicações I-ORG Proc O No. O 309468/2011-6 B-AWARD Marina O Zanin O is O supported O by O Desenvolvimento B-ORG Científico I-ORG e I-ORG Tecnológico I-ORG fellowship O number O 312627/2015-7 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG 2019YFC1315700 O CAMS B-ORG Key I-ORG Laboratory I-ORG of I-ORG Translational I-ORG Research I-ORG on I-ORG Lung I-ORG Cancer I-ORG 2018PT31035 O Aiyou B-ORG foundation I-ORG KY201701 O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2022YFC2505000 O NSFC B-ORG general I-ORG program I-ORG 82272796 O NSFC B-ORG special I-ORG program I-ORG 82241229 O and O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG CIFMS O 2022-I2M-1-009 O This O work O was O funded O by O grants O from O the O Sichuan B-ORG Provincial I-ORG Department I-ORG of I-ORG science I-ORG and I-ORG technology I-ORG international I-ORG scientific I-ORG and I-ORG technological I-ORG innovation I-ORG cooperation I-ORG 2022YFH0026 O China B-ORG Central I-ORG and I-ORG Eastern I-ORG European I-ORG countries I-ORG joint I-ORG education I-ORG project I-ORG 2021092 O the B-ORG earmarked I-ORG fund I-ORG for I-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-42-17 O and O the B-ORG Program I-ORG Sichuan I-ORG Veterinary I-ORG Medicine I-ORG and I-ORG Drug I-ORG Innovation I-ORG Group I-ORG of I-ORG China I-ORG Agricultural I-ORG Research I-ORG System I-ORG SCCXTD-2021-18 O This O work O was O supported O by O in O part O of O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O grant O 61701297 B-AWARD in O part O of O by O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG under O grant O 2018M641982 B-AWARD in O part O of O by O the O China O Scholarship O Council O and O Mitacs O in O part O of O by O JSPS B-ORG KAKENHI I-ORG under O grant O 17K00157 B-AWARD and O in O part O of O by O the O Shanghai O Sailing O Program O under O grant O 1419100 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81170188 O and I-AWARD 30971212 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Chongqing I-ORG CSCT2009BB5069 O and O the O Chongqing B-ORG Municipal I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG 2016HBRC001 O and I-AWARD 2016XMSB0003767 O This O study O was O supported O by O the B-ORG innovation I-ORG project I-ORG from I-ORG the I-ORG Department I-ORG of I-ORG Education I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2014KTSCX098 O Guangdong B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG plan I-ORG project I-ORG 2016A020215142 O and O the B-ORG General I-ORG Programs I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81370463 O to O Liu O B O and O 81570259 B-AWARD to O Liu O SM O This O work O was O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC1004203 O 2018YFC1003703 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81501797 O the O Key O University O Natural O Science O Research O Project O of O Jiangsu O Province O 15KJA320003 O Jiangsu O Six O Talent O Peaks O Jiangsu O Entrepreneurship O O Innovation O Award O the O Key O Project O of O Science O and O Technology O Innovation O of O Nanjing O Medical O University O 2017NJMUCX007 O P.R.T O was O supported O by O a O NIH B-ORG grant O R35GM118112 B-AWARD This O research O was O funded O by O the O Programme B-ORG of I-ORG Introducing I-ORG Talents I-ORG of I-ORG Discipline I-ORG to I-ORG Universities I-ORG No. O D21004 B-AWARD Research B-ORG Project I-ORG Supported I-ORG by I-ORG health I-ORG commission I-ORG of I-ORG Shanxi I-ORG Province I-ORG 2021XM20 O and O Key B-ORG Research I-ORG and I-ORG development I-ORG program I-ORG of I-ORG Shanxi I-ORG province I-ORG No. O 202102130501009 O for O Dr. O Li O Dong O and O Scientific B-ORG and I-ORG Technological I-ORG Innovation I-ORG Programs I-ORG of I-ORG Higher I-ORG Education I-ORG Institutions I-ORG in I-ORG Shanxi I-ORG No. O 2019L0102 O for O Dr. O Caiting O Yang O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81471282 B-AWARD the O Popularization B-ORG Project I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG Sichuan I-ORG Province I-ORG No. O 17PJ228 B-AWARD and O the B-ORG Foundation I-ORG of I-ORG Postgraduate I-ORG Innovation I-ORG Project I-ORG of I-ORG Chongqing I-ORG province I-ORG China I-ORG No. O CYB16102 B-AWARD This O work O was O funded O by O the O Talent B-ORG Introduction I-ORG Project I-ORG Foundation I-ORG of I-ORG Nantong I-ORG University I-ORG 135421615077 O Large B-ORG Instruments I-ORG Open I-ORG Foundation I-ORG of I-ORG Nantong I-ORG University I-ORG KFJN2237 O Nantong B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Project I-ORG MS12021025 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2021M702665 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 2022JQ-482 O This O work O was O funded O by O Key O Laboratory O of O Infrared O Imaging O Materials O and O Detectors O Shanghai O Institute O of O Technical O Physics O Chinese O Academy O of O Sciences O No. O IIMDKFJJ-17-06 O Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG No. O 2016FZ0079 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51201143 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2015M570794 O No. B-AWARD 2018T110993 O R&D O Projects O Funding O from O the O Research O Council O of O Norway O No. O 263875/H30 O This O work O was O supported O by O the B-ORG Shanxi I-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG Grant O Nos O 20120311019-3 B-AWARD 20133054 O The B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG Projects I-ORG in I-ORG Shanxi I-ORG Province I-ORG Grant O Nos O 201803D221004-2 B-AWARD and O the B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG Shanxi I-ORG Province I-ORG Grant O Nos O 201801D221321 B-AWARD This O work O was O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province I-ORG No. O 2014029201 B-AWARD Program B-ORG of I-ORG Education I-ORG Department I-ORG of I-ORG Liaoning I-ORG Province I-ORG L2014307 O the O Key I-ORG Laboratory I-ORG Programme I-ORG of I-ORG Education I-ORG Department I-ORG of I-ORG Liaoning I-ORG Province I-ORG LZ2015076 O This O research O was O funded O by O the O “Ministerio B-ORG de I-ORG Ciencia I-ORG e I-ORG Innovación” I-ORG MCIN/AEI/10.13039/501100011033 B-AWARD and O by O “ERDF B-ORG A I-ORG way I-ORG of I-ORG making I-ORG Europe” I-ORG of I-ORG the I-ORG European I-ORG Union O through O the O projects O AGL2014-57974-R B-AWARD AGL2017-89436-R B-AWARD and O the O “Generalitat B-ORG de I-ORG Catalunya” I-ORG 2017SGR-1574 O The O project O leading O to O these O results O has O received O funding O from O “la B-ORG Caixa” I-ORG Foundation I-ORG ID O 100010434 B-AWARD under O agreement O LCF/PR/PR06/51010001 O This O study O was O supported O by O Grants O from O the O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 7192037 B-AWARD to O JD O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81972678 B-AWARD and O 81502137 B-AWARD to O JD, O No. O 81672439 B-AWARD and O 81872022 B-AWARD to O XS O and O Capital’s B-ORG Funds I-ORG for I-ORG Health I-ORG Improvement I-ORG and I-ORG Research I-ORG CFH O 2018-2-2153 O to O XS. O This O work O was O supported O by O the O Beijing B-ORG Municipal I-ORG Science I-ORG I-ORG Technology I-ORG Commission I-ORG D181100000218003 O the O Non-profit O Central O Research O Institute O Fund O of O Chinese B-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG No. O 2019PT320013 B-AWARD and O the O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG No. O 2018-I2M-1-002 B-AWARD This O funding O body O enabled O the O funding O of O a O researcher O and O nurses O to O carry O out O the O research O and O the O questionnaires O it O had O no O role O in O the O design O of O the O study O data O collection O analyses O results O interpretation O or O the O writing O in O the O manuscript O This O study O was O supported O by O Grants O from O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81503669 O and O 81804168 B-AWARD and O 81673865 B-AWARD the O Outstanding B-ORG Training I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG University I-ORG of I-ORG Chinese I-ORG Medicine I-ORG 2019JC05 O and O the O Outstanding B-ORG Innovative I-ORG Talents I-ORG Support I-ORG Plan I-ORG of I-ORG Heilongjiang I-ORG University I-ORG of I-ORG Chinese I-ORG Medicine I-ORG 2018RCD11 O This O study O was O supported O financially O by O the O Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG No. O KQTD20210811090219022 B-AWARD the O Shenzhen B-ORG Fundamental I-ORG Research I-ORG Program I-ORG No. O JCYJ20200109114225087 B-AWARD and O the O National B-ORG Science I-ORG Fund I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG No. O 81525026 B-AWARD This O work O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81570531 O 81571055 B-AWARD the O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O the O Scientific B-ORG Research I-ORG Support I-ORG Project I-ORG for I-ORG Teachers I-ORG with I-ORG Doctor’s I-ORG Degrees I-ORG 15XLR005 O and O Postgraduate O Research O O Practice O Innovation O Program O of O Jiangsu O Province O KYCX17_1623 O KYCX18_2133 O This O work O was O funded O byAlzheimer O Forschung I-ORG Initiativegrant#16018CB;Austrian O Science I-ORG FundgrantI2889‐B31;Deutsche O ForschungsgemeinschaftgrantDU1626/1‐1 O This O work O was O supported O by O Genome B-ORG Canada I-ORG and I-ORG Genome I-ORG BC I-ORG 202SEQ O 212SEQ B-AWARD 12002 B-AWARD Canada B-ORG Foundation I-ORG for I-ORG Innovation I-ORG 20070 O 30198 B-AWARD 30981 B-AWARD 33408 B-AWARD and O the O BC O Knowledge O Development O Fund O We O gratefully O acknowledge O the O participation O of O our O patients O and O families O the O POG O team O and O the O generous O support O of O the O BC B-ORG Cancer I-ORG Foundation I-ORG and I-ORG Genome I-ORG British I-ORG Columbia I-ORG B20POG O MLT O is O supported O by O the O University O of O British O Columbia O Clinician O Investigator O Program O KAS O is O supported O by O the O Canadian O Institutes O of O Health O Research O and O the O Michael O Smith O Foundation O for O Health O Research O This O work O was O supported O by O the B-ORG National I-ORG key I-ORG research I-ORG and I-ORG development I-ORG projects I-ORG 2018YFD0201205 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31660584 O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-23-C-07 O Gansu B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Key I-ORG Project I-ORG Fund I-ORG No.17ZD2NA015 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Gansu I-ORG References I-ORG Province I-ORG China I-ORG 1610RJZA098 O The O funders O had O no O role O in O the O design O of O the O experiments O data O collection O and O analysis O data O interpretation O and O also O in O writing O the O manuscript O This O study O is O supported O by O the O Guangdong B-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Lung I-ORG Cancer I-ORG Translational I-ORG Medicine I-ORG Grant O No. O 2012A061400006 B-AWARD the O Special B-ORG Fund I-ORG for I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG from I-ORG National I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG PRC I-ORG Grant O No. O 201402031 B-AWARD and O the O Research B-ORG Fund I-ORG from I-ORG Guangzhou I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG Grant O No. O 2014Y2-00050 B-AWARD This O work O was O funded O by O The B-ORG Region I-ORG of I-ORG Southern I-ORG Denmark I-ORG 2012 B-AWARD j.nr I-AWARD 12/7763 O The B-ORG Danish I-ORG Rheumatism I-ORG Association I-ORG R108-A2413 B-AWARD and O The B-ORG A.P I-ORG Møller I-ORG Foundation I-ORG SE B-AWARD no. I-AWARD 2928 I-AWARD 3958 I-AWARD This O work O has O been O supported O by O the O financial O support O of O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 2572018BH01 B-AWARD National B-ORG Undergraduate I-ORG Innovation I-ORG Project I-ORG No. O 201710225127 B-AWARD and O Specialized O Personnel O Start-up O Grant O Also O National B-ORG Construction I-ORG Plan I-ORG of I-ORG World-class I-ORG Universities I-ORG and I-ORG First-class I-ORG Disciplines O No. O 41113237 B-AWARD The O funding O body O of O Fundamental O Research O Funds O for O the O Central O Universities O played O an O important O role O in O the O design O of O the O study O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O D.W.S O was O supported O by O the O TULIP B-ORG Laboratory I-ORG of I-ORG Excellence I-ORG ANR-10-LABX-41 O and O by O the O BIOSTASES B-ORG Advanced I-ORG Grant O funded O by O the O European O Research O Council O under O the O European O Union's O Horizon O 2020 O Research O and O Innovation O Programme O grant O agreement O no. O 666971 B-AWARD K.R.S O was O supported O by O the O NSF B-ORG Alliance I-ORG for I-ORG Building I-ORG Faculty I-ORG Diversity I-ORG Postdoctoral I-ORG Fellowship I-ORG NSF O 733 O grant O no. O DMS-0946431 B-AWARD J.A.B O was O supported O by O the O NSF B-ORG Advanced I-ORG Cyberinfrastructure I-ORG NSF O grant O no. O 1639529 B-AWARD This O study O is O supported O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31325020 O 31401326 I-AWARD 31471445 O the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-03 O Jiangsu B-ORG Collaborative I-ORG Innovation I-ORG Center I-ORG for I-ORG Modern I-ORG Crop I-ORG Production I-ORG JCIC-MCP O Collaborative O Innovation O Center O of O Gene O Resources O and O the O National B-ORG Non-profit I-ORG Program I-ORG by I-ORG Ministry I-ORG of I-ORG Agriculture I-ORG 20140039 O Financial O support O was O provided O by O the O Carolina B-ORG Population I-ORG Center I-ORG University I-ORG of I-ORG North I-ORG Carolina I-ORG at I-ORG Chapel I-ORG Hill I-ORG No. O 5R24 B-AWARD HD050924 O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG No. O R01-HD30880 B-AWARD DK056350 I-AWARD R24 I-AWARD HD050924 I-AWARD and I-AWARD R01-HD38700 O and O the O Fogarty B-ORG International I-ORG Center O National O Institutes O of O Health O No. O 5D43TW007709 B-AWARD and I-AWARD 5D43TW009077 O The O funders O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O study O was O partly O supported O by O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG No. O XDA13020100 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG China I-ORG No. O 2016YFC0502800 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Projects I-ORG of I-ORG Guangdong I-ORG province I-ORG China I-ORG No. O 2015A020216013 B-AWARD 2017B030314052 B-AWARD There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 11974099 B-AWARD Plan O for O Leading O Talent O of O Fundamental O Research O of O the O Central O China O in O 2020 O the O Program B-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Talents I-ORG in I-ORG Universities I-ORG of I-ORG Henan I-ORG Province I-ORG grant O no. O 20HASTIT028 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Henan I-ORG Province I-ORG grant O no. O 202300410068 B-AWARD and O the O Postdoctoral B-ORG Foundation I-ORG of I-ORG Henan I-ORG Province I-ORG 201902029 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41705128 O Nanjing B-ORG University I-ORG of I-ORG Information I-ORG Science I-ORG and I-ORG Technology I-ORG 2016r063 O and O Opening O Project O of O Shanghai B-ORG Key I-ORG Laboratory I-ORG of I-ORG Atmospheric I-ORG Particle I-ORG Pollution I-ORG and I-ORG Prevention I-ORG LAP3 O FDLAP17003 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O QYH O was O supported O by O Nanjing O Star-jelly O Environmental O Consultants O Co O Ltd O The O funder O provided O support O in O the O form O of O salaries O for O author O QYH O but O did O not O have O any O additional O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O specific O roles O of O these O authors O are O articulated O in O the O ‘author O contributions’ O section O This O research O was O funded O by O the O “National O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 51805420 B-AWARD and O 51801034” B-AWARD the O “China O Postdoctoral I-ORG Science I-ORG Foundation O grant O number O 208M631146” B-AWARD and O the O “ShaanXi O National I-ORG Science I-ORG Foundation O grant O number O 2019JM-272” B-AWARD This O study O was O funded O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFC0113500 B-AWARD Major B-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. O 2014C03032 B-AWARD Lung B-ORG Cancer I-ORG Diagnosis I-ORG and I-ORG Treatment I-ORG Technology I-ORG Research I-ORG Center I-ORG of I-ORG Zhejiang I-ORG Province I-ORG JBZX-202007 O Key B-ORG Disciplines I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG in I-ORG Zhejiang I-ORG Province I-ORG No. O 2017-XK-A33 B-AWARD This O work O was O funded O by O grants O from O the O Medical B-ORG Research I-ORG Council I-ORG UK I-ORG IGG O MC_UU_12016/4 B-AWARD and O the O Ministerio B-ORG de I-ORG Ciencia I-ORG Innovación I-ORG y I-ORG Universidades I-ORG PB; O PGC2018-098557-B-100 B-AWARD BVZ O is O supported O by O a O fellowship O from O the O Fundación O Tatiana O Pérez O de O Guzmán O el O Bueno O The O Dundee O Imaging O Facility O is O supported O by O the O ‘Wellcome O Trust I-ORG Technology I-ORG Platform’ O award O 097945/B/11/Z O This O research O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0500400 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81772217 O 81828006 B-AWARD 81971954 B-AWARD and O 81572012 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2018A050506038 O the O Key B-ORG project I-ORG of I-ORG Guangzhou I-ORG science I-ORG research I-ORG 201904020011 O to O HP. O This O research O was O funded O by O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG No. O 2020B1515120013 B-AWARD Guangdong B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG No. O 2020B090924002 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O U2001218 B-AWARD Special B-ORG Support I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2019TQ05Z110 B-AWARD Capital B-ORG Health I-ORG Development I-ORG Scientific I-ORG Research I-ORG Project I-ORG No. O A5210020 B-AWARD and O Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG No. O JSGG20210802153809029 B-AWARD This O study O was O supported O by O the B-ORG National I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81673638 I-AWARD No. I-AWARD 81874352 I-AWARD No. I-AWARD 81873036 I-AWARD and I-AWARD No. I-AWARD 81803760 O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG No. O 2017YFC1702200 O the B-ORG National I-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. O LQ18H280003 O the B-ORG Ten-thousand I-ORG Talents I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. O ZJWR0102035 O the B-ORG Zhejiang I-ORG Province I-ORG Excellent I-ORG Young I-ORG Talents I-ORG Fund I-ORG Project I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG No. O 2020ZQ011 O and O the B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. O 2017C03052 I-AWARD and I-AWARD No. I-AWARD 2015C02032 O This O research O was O supported O by O the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG of I-ORG MOF I-ORG and I-ORG MARA I-ORG CARS-16 O Project O of O Southeast O Observation O Station O for O Jute O and O Kenaf O of O Ministry B-ORG of I-ORG Agriculture O China O K4215007A/KJG16001A O the O Platform B-ORG Project I-ORG of I-ORG Germplasm I-ORG Resources I-ORG for I-ORG Fiber I-ORG Crops I-ORG of I-ORG Fujian I-ORG Province O China O FJPH20006 O and O Innovation B-ORG Fund I-ORG of I-ORG Fujian I-ORG Agriculture I-ORG and I-ORG Forestry I-ORG University O China O KFA19028A O This O work O is O supported O partly O by O the O National B-ORG Planning I-ORG Office I-ORG of I-ORG Philosophy I-ORG and I-ORG Social I-ORG Science I-ORG of O China O No. O 16FJY008 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 11801060 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG No. O ZR2016FM26 B-AWARD and O the O innovation O program O of O Shandong O University O of O Science O and O Technology O No. O SDKDYC190114 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61574114 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFB0400801 B-AWARD The B-ORG fundamental I-ORG research I-ORG funds I-ORG for I-ORG the I-ORG central I-ORG universities I-ORG Z201805198 O and O XJJ2017011 B-AWARD This O project O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31071796 O the O “111” B-ORG Project I-ORG B12006 O and O the O “121” B-ORG konjac I-ORG scientific I-ORG and I-ORG technological I-ORG support I-ORG demonstration I-ORG project I-ORG of I-ORG Chongqing I-ORG 104190/40605014 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51603032 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2572018BB01 O 2572017EB06 B-AWARD Postdoctoral B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 2017M621230 O This O research O was O supported O by O “the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG in I-ORG the I-ORG Twelfth I-ORG Five-year I-ORG Plan I-ORG from I-ORG the I-ORG Chinese I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG No. O 2011BAI11B01 B-AWARD 2014ZX09303305)” O Supporting O the O design O of O the O study O collection O analysis O interpretation O of O data O “National O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81560051)” B-AWARD Supporting O the O manuscript O writing O and O collection O and O “Science O and I-ORG Technology I-ORG project I-ORG of I-ORG Health I-ORG Planning I-ORG Commission I-ORG in I-ORG Jiangxi I-ORG Province I-ORG No. O 2016YNQN12034)” B-AWARD Supporting O the O manuscript O writing O This O research O was O supported O by O the O National B-ORG Key I-ORG R I-ORG I-ORG D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFD0202002 B-AWARD Research B-ORG on I-ORG green I-ORG pest I-ORG control I-ORG technology I-ORG of I-ORG characteristic I-ORG fruit I-ORG No. O 2016GYSH-018 B-AWARD and O Sichuan B-ORG fruit I-ORG innovation I-ORG team I-ORG of I-ORG national I-ORG modern I-ORG agricultural I-ORG industry I-ORG technology I-ORG system I-ORG No. O 2019-2023 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O Open B-ORG Project I-ORG of I-ORG Key I-ORG Laboratory I-ORG of I-ORG Prevention I-ORG and I-ORG treatment I-ORG of I-ORG cardiovascular I-ORG and I-ORG cerebrovascular I-ORG diseases I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG grant O number O XN202006 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG Gannan I-ORG Medical I-ORG University I-ORG grant O number O QD202119 B-AWARD and O the O Innovation B-ORG Project I-ORG of I-ORG Gannan I-ORG Medical I-ORG University I-ORG grant O number O TD2-1703 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC31771240 O the O Hunan B-ORG Provincial I-ORG Fund I-ORG for I-ORG Philosophy I-ORG and I-ORG Social I-ORG Sciences I-ORG 15YBA263 O the O Foundation B-ORG of I-ORG Education I-ORG Department I-ORG of I-ORG Hunan I-ORG Province I-ORG of I-ORG China I-ORG 18A036 O and O the O 13th O Five-years O Plan O of O national O education O science O the O key O Research O topics O of O the O Ministry B-ORG of I-ORG Education I-ORG DBA180316 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O a O research O grant O from O the O Council B-ORG of I-ORG Scientific I-ORG and I-ORG Industrial I-ORG Research I-ORG CSIR O Grant O 27(0367)/20/EMR-II B-AWARD Govt O of O India O to O ASG O Sarmistha O Biswal O SB) O is O supported O by O a O DST-INSPIRE B-ORG Doctoral I-ORG Fellowship I-ORG from I-ORG the I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Government I-ORG of I-ORG India I-ORG DST/INSPIRE/03/2015/150440 O and O by O the O British B-ORG Council I-ORG for I-ORG Newton-Bhabha I-ORG fellowship I-ORG DST/INSPIRE/NBHF/2018/12 O The O work O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51603029 B-AWARD and O 51773028 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017M623001 O and O National B-ORG Postdoctoral I-ORG Program I-ORG for I-ORG Innovative I-ORG Talents I-ORG BX201700044 O This O research O was O funded O in O part O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China O No. O 2017YFC1405302 B-AWARD Key B-ORG Project I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences O No.ZDRW-ZS-2016-6-3 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O No. B-AWARD 41771473 O LIESMARS O Special O Research O Funding O This O study O was O supported O by O Hubei B-ORG Province I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG Grant O No. O 2020BCB025 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 82003511 B-AWARD and O Translational B-ORG Medicine I-ORG and I-ORG Interdisciplinary I-ORG Research I-ORG Joint I-ORG Fund I-ORG Project I-ORG of I-ORG Zhongnan I-ORG Hospital I-ORG of I-ORG Wuhan I-ORG University I-ORG Grant O No. O ZNLH201905 B-AWARD This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81572514 O U1301221 B-AWARD 81402106 B-AWARD 81272808 B-AWARD 81825016 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG China I-ORG 2016A030313244 O Grant O 2013]163 B-AWARD from O Key B-ORG Laboratory I-ORG of I-ORG Malignant I-ORG Tumor I-ORG Molecular I-ORG Mechanism I-ORG and I-ORG Translational I-ORG Medicine I-ORG of I-ORG Guangzhou I-ORG Bureau I-ORG of I-ORG Science I-ORG and I-ORG Information I-ORG Technology O Grant O KLB09001 B-AWARD from O the O Key B-ORG Laboratory I-ORG of I-ORG Malignant I-ORG Tumor I-ORG Gene I-ORG Regulation I-ORG and I-ORG Target I-ORG Therapy I-ORG of I-ORG Guangdong I-ORG Higher I-ORG Education I-ORG Institutes O and O grants O from O the O Guangdong B-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG 2015B050501004 O 2017B020227007 B-AWARD The O funders O had O no O involvement O in O study O design O in O the O collection O analysis O or O interpretation O of O data O in O the O writing O of O the O report O or O in O the O decision O to O submit O the O paper O for O publication O This O study O was O financed O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Province I-ORG CN) O 1508085MC53 O National B-ORG Science I-ORG and I-ORG Technology I-ORG Pillar I-ORG Program I-ORG during I-ORG the I-ORG Twelfth I-ORG Five-year I-ORG plan I-ORG period I-ORG 2015BAD03B06 O The B-ORG Open I-ORG Fund I-ORG of I-ORG Anhui I-ORG Province I-ORG Key I-ORG Laboratory I-ORG of I-ORG Local I-ORG Livestock I-ORG and I-ORG Poultry I-ORG Genetical I-ORG Resource I-ORG Conservation I-ORG and I-ORG Breeding I-ORG AKLGRCB2017008 O National B-ORG key I-ORG R&D I-ORG project I-ORG 2018YFD0501500 O This O research O was O funded O by O Science B-ORG Foundation I-ORG Ireland I-ORG Investigator O Award O IvP O grant O number O 13/IA/1840 B-AWARD the O AMCARE O consortium O a O European O Union’s O Seventh B-ORG Framework I-ORG Programme I-ORG FP7/2007-2013 O under O grant O agreement O number O 604531 B-AWARD and O a O Health O Research O Board O Summer O Studentship O grant O to O M.C O S.F O receives O support O from O the O Science O Foundation O Ireland O SFI O Centre O for O Research O in O Medical O Devices O CÚRAM O and O the O European B-ORG Regional I-ORG Development I-ORG Fund I-ORG Grant O 13/RC/2073 B-AWARD This O research O was O funded O by O the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Grant O NO. O 2019YFC1906302 B-AWARD O 2019YFC1906304 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O NO. O 51978047 B-AWARD O 5217100753 B-AWARD and O Tianjin B-ORG Education I-ORG Commission I-ORG Scientific I-ORG Research I-ORG Planning I-ORG Project I-ORG grant O number O 2021KJ064 B-AWARD This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81860762 O the O Qinghai B-ORG Fundamental I-ORG Scientific I-ORG and I-ORG Technological I-ORG Research I-ORG Plan I-ORG 2018-ZJ-721 O and O the O Scientific B-ORG Research I-ORG Guiding I-ORG Plan I-ORG Topic I-ORG of I-ORG Qinghai I-ORG Hygiene I-ORG Department I-ORG 2018-wjzdx-131 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O partially O supported O by O grants O from O Xunta B-ORG de I-ORG Galicia I-ORG U.R O IN606B-2021/001 B-AWARD and O GRC B-AWARD ED431C2021/26 O the O Spanish B-ORG Ministry I-ORG of I-ORG Economy I-ORG and I-ORG Competitiveness I-ORG RTI2018-099597-B-100 O and O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III I-ORG ISCIII O I.L O PI18/00159 B-AWARD and O the O Spanish B-ORG Research I-ORG Network I-ORG on I-ORG Cerebrovascular I-ORG Diseases I-ORG INVICTUS I-ORG PLUS I-ORG M.L.-L O RD16/0019/0001 B-AWARD The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O Science B-ORG and I-ORG Technology I-ORG Development I-ORG Project I-ORG of I-ORG Jilin I-ORG Province I-ORG 3D5177723429 O Science B-ORG and I-ORG Technology I-ORG of I-ORG Jilin I-ORG Province I-ORG Jilin I-ORG Province I-ORG Key I-ORG Laboratory I-ORG 3D517K363429 O and O The B-ORG Role I-ORG and I-ORG Molecular I-ORG Mechanism I-ORG of I-ORG EMT I-ORG in I-ORG the I-ORG Resistance I-ORG of I-ORG ROS1-positive I-ORG Lung I-ORG Cancer I-ORG 20180101014JC O Changchun O Jilin O China O The O research O fund O was O used O for O data O collection O This O research O was O financially O supported O by O the O Special B-ORG Fund I-ORG for I-ORG Agro-scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG No. O 201303042 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31172309 O and O the O Special B-ORG Cooperation I-ORG Funds I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Hainan I-ORG Province I-ORG No. O KJHZ2015-31 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2021YFD1300800 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32072725 O and O the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG of I-ORG MOF I-ORG and I-ORG MARA I-ORG CARS-35 O This O work O was O supported O by O National B-ORG Science I-ORG Foundation I-ORG 1456098 O to O A.D.L O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31671370 O 31301093 B-AWARD 11201224 B-AWARD and O 11301294 B-AWARD to O T.Z O the O Youth B-ORG Innovation I-ORG Promotion I-ORG Association I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG 2015080 O a O Biotechnological B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG BB/P006493/1 O to O Z.Y O and O in O part O by O the O Radcliffe O Institute O for O Advanced O Study O at O Harvard O University O This O study O was O supported O by O grants O from O 863 O Program B-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG No. O 2015AA020508 B-AWARD URLs:http://www.most.gov.cn/eng/programmes1 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31571076 B-AWARD URLs:http://www.nsfc.gov.cn O and O the O Shanghai B-ORG Key I-ORG Discipline I-ORG Foundation I-ORG No. O B111 B-AWARD URLs:http://www.shmec.gov.cn O to O HY. O This O study O was O supported O by O The B-ORG Key I-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81430040 B-AWARD X.Y O General B-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81571738 B-AWARD O 81871403 B-AWARD J.S O The B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFA0100900 B-AWARD J.S O Medical B-ORG and I-ORG Health I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2017209189 B-AWARD M.Z. O 2019338991 B-AWARD F. O Z O This O research O was O funded O by O the O National B-ORG Major I-ORG Projects I-ORG of I-ORG China I-ORG 2016ZX08010004-004 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31771418 O 32272126 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG China O 2016CFB549 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG Central I-ORG Universities I-ORG HUST I-ORG 2021XXJS070 O 3004170157 B-AWARD and O Wuhan B-ORG Knowledge I-ORG Innovation I-ORG Project I-ORG 2022020801010073 O This O work O was O also O supported O by O the O Opening B-ORG Fund I-ORG of I-ORG Key I-ORG Laboratory I-ORG of I-ORG Forage I-ORG and I-ORG Endemic I-ORG Crop I-ORG Biology I-ORG Ministry I-ORG of I-ORG Education I-ORG FECBOF2021002 O the O Opening B-ORG Fund I-ORG of I-ORG Hubei I-ORG Key I-ORG Laboratory I-ORG of I-ORG Bioinorganic I-ORG Chemistry I-ORG I-ORG Materia I-ORG Medica I-ORG BCMM202205 O the O Start-Up B-ORG Research I-ORG Funding I-ORG of I-ORG Wuhan I-ORG Polytechnic I-ORG University I-ORG 2021RZ100 O 53210052172 B-AWARD and O the O Research B-ORG Project I-ORG of I-ORG Wuhan I-ORG Polytechnic I-ORG University I-ORG 2023Y24 O The O study O was O supported O by O the B-ORG Nanjing I-ORG Medical I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Foundation I-ORG YKK15070 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 021414380135 O and O the B-ORG Clinical I-ORG Medicine I-ORG Research I-ORG Special I-ORG Fund I-ORG of I-ORG Chinese I-ORG Medical I-ORG Association I-ORG 17020220691 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O J1210053 B-AWARD 31100445 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG DL13EA08-03 O financial O support O from O postdoctoral B-ORG science-research I-ORG developmental I-ORG foundation I-ORG of I-ORG Heilongjiang I-ORG province I-ORG LBH-Q11185 O Research O supported O by O a O grant O from O the O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG 480807/2011-6 O and O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG de I-ORG Minas I-ORG Gerais I-ORG APQ-01237-11 O This O study O was O financed O in O part O by O the O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG Finance O Code O 001 B-AWARD and O Print O Fiocruz-CAPES O Program O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O West B-ORG Light I-ORG Foundation I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG CAS O XAB2017B20 O China B-ORG Scholarship I-ORG Council I-ORG CSC O 201804910323 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 61505246 O 61535015 B-AWARD This O research O was O supported O by O the B-ORG Special I-ORG Fund I-ORG for I-ORG Agro-scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG no. O 201203047 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 31372114 B-AWARD Program B-ORG of I-ORG International I-ORG Science I-ORG and I-ORG Technology I-ORG Cooperation I-ORG 2011DFB31580 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG China I-ORG LR16C150001 O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81702569 O 81801413 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20170151 O Nanjing B-ORG Medical I-ORG Science I-ORG and I-ORG Technique I-ORG Development I-ORG Foundation I-ORG JQX18009 O Jiangsu O Provincial O Women O and O Children O Health O Research O Project O F201762 O Jiangsu O Province O “six O talent O peak” O personal O training O project O 2016-WSW-086 O 2015-WSW-043 O and O Science O and O Technology O Development O Foundation O Item O of O Nanjing O Medical O University O 2016NJMUZD065 O This O study O was O supported O by O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31400679 O the B-ORG Key I-ORG Deployment I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG KSZD-EW-Z-015 O the B-ORG National I-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 863 O Program O 2012AA022203 B-AWARD This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.32202777 O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Province I-ORG China I-ORG No.2208085MC80 O 2008085MC91 B-AWARD the B-ORG Anhui I-ORG Higher I-ORG Institutions I-ORG Natural I-ORG Science I-ORG Foundation I-ORG China I-ORG No. O 2022AH040117 B-AWARD KJ2021A0151 B-AWARD the B-ORG Special I-ORG Fund I-ORG for I-ORG Anhui I-ORG Agriculture I-ORG Research I-ORG System I-ORG China I-ORG No. O AHCYJSTX-05-07 B-AWARD AHCYJSTX-05-21 B-AWARD and O the B-ORG Anhui I-ORG Agricultural I-ORG University’s I-ORG Scientific I-ORG Research I-ORG Funding I-ORG Projects I-ORG for I-ORG Introducing I-ORG and I-ORG Stabling I-ORG Talents I-ORG China I-ORG No. O rc392105 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81572572 O 81702570 B-AWARD and O 81702575 B-AWARD the O Scientific B-ORG and I-ORG Technological I-ORG Research I-ORG Projects I-ORG of I-ORG Xinjiang I-ORG Production I-ORG and I-ORG Construction I-ORG Corp I-ORG 2017DB012 O and O the O Union B-ORG Hospital I-ORG Scientific I-ORG Research I-ORG Fund I-ORG 2018-229 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31500584 O the O Inner B-ORG Mongolia I-ORG Autonomous I-ORG Region I-ORG Applied I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Foundation I-ORG Plan I-ORG 2021GG0085 O and O 2021GG004 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Inner I-ORG Mongolia I-ORG Autonomous I-ORG Region I-ORG 2022MS03029 O the O Major B-ORG Ordos I-ORG City I-ORG projects I-ORG 2021EEDSCXQDFZ011 O and O the O Inner B-ORG Mongolia I-ORG Ordos I-ORG Application I-ORG Research I-ORG and I-ORG Technology I-ORG Development I-ORG Project I-ORG 2021YY O SHE I-AWARD 106-55 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O grants O from O theNetherlands O Organization I-ORG for I-ORG Scientific I-ORG Research(016.155.195 O theJames O S. I-ORG McDonnell I-ORG Foundation(220020502 O and O theJacobs O Foundation(2017 O 1261 I-AWARD 02) O to O WEF O Funded O by O Brain B-ORG Korea I-ORG BK) I-ORG 21 I-ORG Plus I-ORG Project I-ORG 22A20153713433 B-AWARD to O Ms O Momna O Rubab O Korea B-ORG Research I-ORG Fellowship I-ORG Program I-ORG National I-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG Ministry I-ORG of I-ORG Science I-ORG Young I-ORG Researchers I-ORG Program I-ORG for I-ORG 2018007551 B-AWARD to O Dr O Ramachandran O Chelliah O Korea B-ORG Research I-ORG Fellowship I-ORG Program I-ORG through I-ORG the I-ORG National I-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF I-ORG 2017H1D3A1A01052610 B-AWARD to O Dr O Kandasamy O Saravanakumar O This O study O was O financially O supported O by O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG Fund I-ORG of I-ORG Shandong I-ORG Province I-ORG 2016GSF202001 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81872963 O the O Standardization O Project O Fund O of O Administration O of O Traditional O Chinese O Medicine O ZYBZH-Y-SD-32 O and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC1701503 O This O work O was O supported O by O the O National B-ORG Key I-ORG Project I-ORG 2016ZX08009003-006-003 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31372295 O and O 31330074 B-AWARD and O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG ASTIP-IAS16 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31670690 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD1000601 O the O Guangdong O Natural O Science O Foundation O for O Distinguished O Young O Scholar O 2016A030313652 O the O Youth B-ORG Innovation I-ORG Promotion I-ORG Association I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Y821131001 O and O the O Pearl O River O Science O and O Technology O New O Star O Fund O of O Guangzhou O 201806010.018 O This O work O was O funded O by O federal O agencies O of O the O USA O including O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG through O the O Director’s O New O Innovator O Award O DP2-GM132934 B-AWARD and O a O Cardiovascular O Bioengineering O Training O Program O H.C.F O T32-HL076124 O It O was O also O supported O by O the O National B-ORG Science I-ORG Foundation O DMR B-AWARD 1709238 O and O the O Air B-ORG Force I-ORG Office I-ORG of I-ORG Scientific I-ORG Research O FA9550-18-1-0262 B-AWARD This O study O was O supported O in O part O by O the O China B-ORG Agriculture I-ORG Research I-ORG Systems I-ORG CARS-41-K02 O to O KW, O Integration B-ORG Innovation I-ORG Project I-ORG of I-ORG Layer I-ORG Research I-ORG Systems I-ORG in I-ORG Jiangsu I-ORG Province I-ORG SXGC[2017]252 O to O KW, O and O Fund B-ORG for I-ORG Independent I-ORG Innovation I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG in I-ORG Jiangsu I-ORG Province I-ORG CX[16]1008 O to O LQ. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O presented O in O this O paper O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51402241 B-AWARD the O Research B-ORG Project I-ORG of I-ORG the I-ORG Education I-ORG Department I-ORG of I-ORG Sichuan I-ORG Province I-ORG No. O 15ZB0138 B-AWARD and O the O Open B-ORG Research I-ORG Subject I-ORG of I-ORG Key I-ORG Laboratory I-ORG of I-ORG Special I-ORG Materials I-ORG and I-ORG Manufacturing I-ORG Technology I-ORG No. O SZJJ2017-063 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG China I-ORG 31971759 O the O Modern B-ORG Agricultural I-ORG Industry I-ORG Technology I-ORG System I-ORG China I-ORG BAIC02-2023 O Open B-ORG Project I-ORG of I-ORG Provincial I-ORG and I-ORG Ministerial I-ORG Scientific I-ORG Research I-ORG Platform I-ORG Fuyang I-ORG Normal I-ORG University I-ORG FSKFKT027D O This O work O is O supported O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 81672904 B-AWARD 61427806 B-AWARD National O Key O Research O and O Development O Program O of O China O Grant O No. O 2015BAI01B02 O Project B-ORG of I-ORG Department I-ORG of I-ORG Education I-ORG of I-ORG Guangdong I-ORG Province I-ORG Grant O No. O 2016KTSCX123 B-AWARD Postgraduate B-ORG Innovation I-ORG Development I-ORG Fund I-ORG of I-ORG Shenzhen I-ORG University I-ORG Grant O No. O 315-0000470204 B-AWARD and O Medical B-ORG Young I-ORG Scientists I-ORG Program I-ORG of I-ORG Shenzhen I-ORG University I-ORG Grant O No. O 1). O This O work O was O funded O through O the O Programa B-ORG Operacional I-ORG Regional I-ORG do I-ORG Centro I-ORG CENTRO2020 O CENTRO-01-0145-FEDER-000014 B-AWARD and O the O Strategic O Project O of O CIEPQPF O UIDB/00102/2020 O which O is O financed O by O the O FCT B-ORG through O national O funds O R.P O Rodrigues O was O funded O by O the O Fundação B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG Tecnologia I-ORG FCT O through O the O Ph.D O grant O SFRH/BD/145694/2019 O This O research O was O supported O financially O by O the O country’s O construction O plan O of O world-class O universities O and O first-class O disciplines O the O central O government’s O major O increase O and O decrease O project O “Building O Capacity I-ORG for I-ORG Sustainable I-ORG Utilization I-ORG of I-ORG Precious I-ORG Chinese I-ORG Medicine I-ORG Resources” O 2060302 O This O work O was O also O supported O by O Special O Funds O Project O for O the O Construction O of O Modern O Agricultural O Technology O System O CARS-21-03B O Postgraduate O Research O Innovation O Program O of O Jiangsu O Province O Anhui O Provincial O Academy O of O Agricultural O Sciences O Talent O Development O Special O Fund O Project O 17F0308 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81573555 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province O China O BK O 20160097 O This O research O was O funded O by O the O Talent B-ORG Program-Outstanding I-ORG Youth I-ORG Science I-ORG Project I-ORG Liaoning I-ORG No. O XLYC1807199 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 21601076 B-AWARD and O the O Australian B-ORG Research I-ORG Council I-ORG DE170100092 O This O work O was O supported O by O NSFC B-ORG 81670154/H0812 O 81470355/H1616 B-AWARD 81100378/H0812 B-AWARD Projects O 1201410214 O 2014A030313492 B-AWARD from O the O Foundation B-ORG of I-ORG Bureau I-ORG of I-ORG Education I-ORG of I-ORG Guangzhou I-ORG Municipality I-ORG and O GD-NSF B-ORG to O X.S O the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2006AA02Z4B5 O NSFC O 81272451/H1609 O 81472762/H1609 B-AWARD and O MOE B-ORG 20134423110002 O to O J.L O This O work O was O supported O by O the O Department B-ORG for I-ORG International I-ORG Development I-ORG 202796 O Medical B-ORG Research I-ORG Council I-ORG G81174H O and O Child B-ORG Health I-ORG Research I-ORG Charitable I-ORG Incorporated I-ORG Organisation I-ORG 521297 O The O authors O are O grateful O for O the O financial O support O for O this O study O from O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No.HIT.NSRIF.201602 O HIT.NSRIF.201704 B-AWARD HIT.MKSTISP.201617 B-AWARD the O Key B-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shandong I-ORG Grant O No. O 2017CXGC0922 B-AWARD 2018GGX103003 B-AWARD and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG Grant O No. O ZR2017QEE005 B-AWARD ZR2017PEE010 B-AWARD Iwate O Medical O University O provided O support O in O the O form O of O salaries O for O all O authors O This O work O was O supported O by O Grant-in-Aid O for O Scientific O Research O KAKENHI O of O the O Japan B-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG JSPS O grant O numbers O 20390054 B-AWARD EK O and O JH O and O partly O supported O by O a B-ORG Grant-in-Aid I-ORG for I-ORG Strategic I-ORG Medical I-ORG Science I-ORG Research I-ORG S1491001 O 2014-2018 O from O the O Ministry O of O Education O Culture O Sports O Science O and O Technology O of O Japan O EK O and O JH) O and O the B-ORG NIBB I-ORG Cooperative I-ORG Research I-ORG Program I-ORG number O 15-701 B-AWARD EK O None O of O the O funders O had O any O additional O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O is O supported O by O grants B-ORG from I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG the I-ORG People’s I-ORG Republic I-ORG of I-ORG China I-ORG 2006BAI01A11 O 2011BAI08B01 I-AWARD 2011BAI08B02 I-AWARD 2012ZX09303-005-001 I-AWARD 2013BAI09B03 I-AWARD and I-AWARD 2015BAI09B01 O a B-ORG grant I-ORG from I-ORG the I-ORG Beijing I-ORG Biobank I-ORG of I-ORG Cerebral I-ORG Vascular I-ORG Disease I-ORG D131100005313003 O and O a B-ORG grant I-ORG from I-ORG Beijing I-ORG Institute I-ORG for I-ORG Brain I-ORG Disorders I-ORG BIBD-PXM2013_014226_07_000084 O This O study O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Regional I-ORG Science I-ORG Fund I-ORG of I-ORG China I-ORG 81760112 O the B-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017b020247057 O and O the B-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangzhou I-ORG 201804010211 O The O funding O sources O had O no O role O in O the O design O of O this O study O and O collection O execution O analyses O interpretation O of O the O data O writing O the O manuscript O or O decision O to O submit O results O This O work O was O supported O by O Horticulture B-ORG Innovation I-ORG Australia I-ORG ST16010 O through O funding O from O the O Australian O Government O Department O of O Agriculture O as O part O of O its O Rural O R&D O for O Profit O program O and O Grains O Research O and O Development O Corporation O Additional O funding O was O provided O by O the O Plant B-ORG Biosecurity I-ORG Cooperative I-ORG Research I-ORG Centre(PBCRC O No. O 2153 B-AWARD and O Agriculture B-ORG Victoria's I-ORG Improved I-ORG Market I-ORG Access I-ORG for I-ORG Horticulture I-ORG programme(CMI105584 O A.M.P O and O J.B O were O further O supported O by O an O Australian O Government O Research O Training O Program O Scholarship O This O work O was O financially O supported O by O the O project O “Research B-ORG on I-ORG Extraction I-ORG and I-ORG Utilization I-ORG Technology I-ORG of I-ORG ‘Three I-ORG Berries’ I-ORG Functional I-ORG Components I-ORG in I-ORG Nanjing I-ORG National I-ORG Agricultural I-ORG High-Tech I-ORG Industry I-ORG Demonstration I-ORG Zone” I-ORG BE2020344 O the B-ORG earmarked I-ORG fund I-ORG for I-ORG Jiangsu I-ORG Agricultural I-ORG Industry I-ORG Technology I-ORG System I-ORG JATS O 2021]511 I-AWARD and I-AWARD JATS I-AWARD 2022]510 O and O the O JBGS B-ORG Project I-ORG of I-ORG Seed I-ORG Industry I-ORG Revitalization I-ORG in I-ORG Jiangsu I-ORG Province I-ORG JBGS O 2021]021 O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 51425503 B-AWARD and O 51705293 B-AWARD Taishan B-ORG Scholar I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG grant O number O TS20130922 B-AWARD and O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG grant O number O 2017M610422 B-AWARD Health O sciences O research O grants O comprehensive O research O on O lifestyle-related O diseases O including O cardiovascular O diseases O and O diabetes O mellitus O H25-016 B-AWARD and O H25-029 B-AWARD from O the O Ministry B-ORG of I-ORG Health I-ORG Labour I-ORG and I-ORG Welfare I-ORG of O Japan O JSPS O KAKENHI O grant O number O 15K21389 B-AWARD 18K10095 B-AWARD from O the O Japan B-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG JSPS O AMED O grant O number O JP18ck0106370 B-AWARD from O Japan B-ORG Agency I-ORG for I-ORG Medical I-ORG Research I-ORG and I-ORG Development I-ORG the B-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG during I-ORG the I-ORG Twelfth I-ORG Five-Year-Plan I-ORG Period I-ORG of I-ORG China I-ORG 2012BAD02B02 O This O work O was O supported O by O the B-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG of I-ORG Hubei I-ORG Province I-ORG 2015BBA202 O the B-ORG Excellent I-ORG Talents I-ORG Support I-ORG Program I-ORG of I-ORG Wuhan I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG CX201606-05 O All O the O authors O undertook O the O study O design O and O collection O analysis O interpretation O of O data O and O in O writing O the O manuscript O Funding O bodies O only O provided O financial O support O towards O this O study O Funding O bodies O included O the O Stafford B-ORG Fox I-ORG Medical I-ORG Research I-ORG Foundation I-ORG 489798 O McCusker B-ORG Charitable I-ORG Foundation I-ORG 49979 O Buxton B-ORG Foundation I-ORG 4676 O Henty B-ORG Community I-ORG 4879 O Henty B-ORG Lions I-ORG Club I-ORG 4880 O Mason B-ORG Foundation I-ORG 47107 O Mr O Douglas O Stutt O Blake B-ORG Beckett I-ORG Trust I-ORG Foundation I-ORG 4579 O Alison B-ORG Hunter I-ORG Memorial I-ORG Foundation I-ORG 4570 O and O the O Change B-ORG for I-ORG ME I-ORG Charity I-ORG 4575 O Funding O bodies O This O study O was O sponsored O by O the O Provincial B-ORG Key I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Sichuan I-ORG Province I-ORG no. O 2014SZ0037 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 81400483 B-AWARD and O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project(no O 2016YFC1102704 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Basic O Science O Research O Program O through O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O funded O by O the O Ministry O of O Education O 2017R1D1A3B03027875 O University B-ORG of I-ORG Brain I-ORG Education I-ORG 2017-03 O and O a O faculty O research O grant O of O Yonsei B-ORG University I-ORG College I-ORG of I-ORG Medicine I-ORG for O 6-2014-0045 O The O funder O played O no O role O in O the O design O and O conduct O of O the O study O collection O management O analysis O and O interpretation O of O the O data O preparation O review O or O approval O of O the O manuscript O and O decision O to O submit O the O manuscript O for O publication O This O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 31700340 B-AWARD and O 31670418 B-AWARD the O Scientific B-ORG and I-ORG Technological I-ORG Research I-ORG Program I-ORG of I-ORG Chongqing I-ORG Municipal I-ORG Education I-ORG Commission I-ORG KJ1600312 O the O Research B-ORG Project I-ORG of I-ORG Chongqing I-ORG Science I-ORG and I-ORG Technology I-ORG Committee I-ORG cstc2017jcyjAX0474 O and O the O Doctoral B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Chongqing I-ORG Normal I-ORG University I-ORG 16XLB014 O China O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Funding O was O provided O by O Fondo B-ORG Nacional I-ORG de I-ORG Desarrollo I-ORG Científico I-ORG y I-ORG Tecnológico I-ORG FONDECYT O 1140504 B-AWARD http://www.conicyt.cl/fondecyt O Mejoramiento O de O la O Calidad O y O la O Equidad O en O la O Educación O Superior O MECESUP O 2-UCH0604 B-AWARD http://www.mecesup.cl O NB; O and O Comisión O Nacional O de O Investigación O Científica O y O Tecnológica O CONICYT O 21110252 B-AWARD http://www.conicyt.cl/becas-conicyt O PC. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O paper O was O funded O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 71503059 B-AWARD the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O DUT15RC B-AWARD 3) I-AWARD 061 O Liaoning B-ORG Finance I-ORG Fund I-ORG No.16C011 O the B-ORG Social I-ORG Science I-ORG Foundation I-ORG of I-ORG Dalian I-ORG 2016dlskyb005 O This O research O was O mainly O supported O by O a O grant O from O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD1000604 O and O partially O supported O by O a O grant O of O the O 863 O Program O from O the O Chinese B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2013AA102605 O a O grant O from O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31470682 O 31670682 B-AWARD and O 31570666 B-AWARD the O Zhejiang O Agriculture O fruit O New B-ORG Variety I-ORG Breeding I-ORG Major I-ORG Science I-ORG and I-ORG Technology I-ORG Special I-ORG 2016C02052-13 O and O the O Teacher O Professional O Development O Project O of O Domestic B-ORG Visiting I-ORG Scholar I-ORG in I-ORG Zhejiang I-ORG Province I-ORG FX2015040 O This O study O was O supported O by O the B-ORG research I-ORG about I-ORG Chongqing I-ORG Key I-ORG technology I-ORG and I-ORG application I-ORG demonstration I-ORG of I-ORG medical I-ORG imaging I-ORG depth I-ORG intelligent I-ORG diagnostic I-ORG platform I-ORG cstc2018jszx-cyztzxX0017 O Nursery B-ORG Talents I-ORG of I-ORG Army I-ORG Medical I-ORG University I-ORG 2017MPRC-07 O Military B-ORG medical I-ORG innovation I-ORG ability I-ORG improvement I-ORG plan I-ORG of I-ORG medical I-ORG staff I-ORG in I-ORG the I-ORG First I-ORG Affiliated I-ORG Hospital I-ORG to I-ORG Army I-ORG Medical I-ORG University I-ORG SWH2018QNWQ-04 O and O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG 2016YFC0107101 O HSH O and O IT O were O supported O by O the O Luxembourg O National O Research O Fund O FNR O through O the O National O Centre O of O Excellence O in O Research O NCER O on O Parkinson’s O disease O BC O and O SV O were O supported O in O part O by O NSF B-ORG awards O CCF-1217793 B-AWARD and O EAGER-1415498 B-AWARD RMTF O was O funded O by O the O Interagency O Modeling O and O Analysis O Group O Multi-scale O Modeling O Consortium O U01 O awards O from O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences O award O GM102098 B-AWARD and O U.S B-ORG Department I-ORG of I-ORG Energy I-ORG Office I-ORG of I-ORG Science I-ORG Biological I-ORG and I-ORG Environmental I-ORG Research I-ORG Program O award O DE-SC0010429 B-AWARD PAW O JHH O DJH O received O funding O from O EPSRC B-ORG grant O “MIMIC” O EP/K020439/1 B-AWARD and O EU B-ORG FP7 I-ORG Virtual O Physiological O Human O grant O “VPH-PRISM” O FP7-ICT-2011-9 O 601040 O VV O received O funding O from O Marie-Curie B-ORG Fellowship I-ORG FP7-PEOPLE-2013-IEF O 627025 O TS O received O funding O from O the O European B-ORG Research I-ORG Council I-ORG FP7/2007-2013)/ERC O Grant O No. O 336839-ReEngineeringCancer B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O research O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31702110 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG KJQN201830 O Science B-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG Guangxi I-ORG Guike O AA17204027 O This O work O was O supported O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2019ZY29 O the O State O ‘13.5’ O Key O Research O Program O of O China O No. O 2016YFD0600102 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31670182 O 31761133009 B-AWARD 31530084 B-AWARD 31401149 B-AWARD 3180030099 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M631246 O and O the O Program B-ORG of I-ORG Introducing I-ORG Talents I-ORG of I-ORG Discipline I-ORG to I-ORG Universities I-ORG 111 O project I-AWARD B13007 O This O work O was O supported O by O a O grant O from O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG Grant O Number O 2018YFC1002102 B-AWARD the B-ORG International I-ORG Peace I-ORG Maternal I-ORG and I-ORG Child I-ORG Health I-ORG Institute I-ORG Clinical I-ORG Research I-ORG Program I-ORG Grant O Number O GFY5826 B-AWARD Scientific B-ORG Research I-ORG Project I-ORG of I-ORG Shanghai I-ORG Health I-ORG and I-ORG Fitness I-ORG Commission I-ORG Grant O Number O 20184Y0344 B-AWARD Translational B-ORG Medicine I-ORG Cross I-ORG Fund I-ORG from I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG Grant O Number O ZH2018QNA36 B-AWARD Medical B-ORG Engineering I-ORG Cross I-ORG youth I-ORG funds I-ORG from I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG Grant O Number O YG2017QN38 B-AWARD and O youth B-ORG funds I-ORG from I-ORG Shanghai I-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG s O 2018Y0344 B-AWARD This O research O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province O grant O number O ZR2020MF082 B-AWARD the O Collaborative B-ORG Innovation I-ORG Center I-ORG for I-ORG Intelligent I-ORG Green I-ORG Manufacturing I-ORG Technology I-ORG and I-ORG Equipment I-ORG of I-ORG Shandong I-ORG Province O grant O number O IGSD-2020-012 B-AWARD the O Qingdao B-ORG Top I-ORG Talent I-ORG Program I-ORG of I-ORG Entrepreneurship I-ORG and I-ORG Innovation O grant O number O 19-3-2-8-zhc B-AWARD the O Qingdao B-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Postgraduate I-ORG Independent I-ORG Research I-ORG and I-ORG Innovation I-ORG Project O grant O number O B2022KY005 B-AWARD and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program O grant O number O 2018YFB1601500 B-AWARD This O work O was O supported O by O Guangdong B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG No. O 2015B070701019)http://pro.gdstc.gov.cn/egrantweb/RCH B-AWARD preparation O of O the O manuscript O Environment B-ORG Construction I-ORG and I-ORG Capacity I-ORG Building I-ORG of I-ORG GDAS’ I-ORG Research I-ORG Platform I-ORG No. O 2016GDASPT-0107)http://www.gdas.gd.cn/RCH B-AWARD preparation O of O the O manuscript O and O Guangzhou B-ORG science I-ORG and I-ORG technology I-ORG plan I-ORG projects I-ORG 201604020030)http://www.gzsi.gov.cn/LC O preparation O of O the O manuscript O This O work O was O supported O by O Jiangsu B-ORG Modern I-ORG Hospital I-ORG Management I-ORG Research I-ORG GRANT O O AWARD O NUMBER O JSY-3-2019-053 B-AWARD Technological B-ORG Innovation I-ORG and I-ORG Demonstration I-ORG of I-ORG Social I-ORG Undertakings I-ORG Projects I-ORG GRANT O O AWARD O NUMBER O MS32017012 B-AWARD and O the O Training B-ORG Program I-ORG of I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG for I-ORG College I-ORG Students I-ORG in I-ORG Jiangsu I-ORG GRANT O O AWARD O NUMBER O 201913993001Y B-AWARD 201913993021H O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Research O support O was O provided O by O the O following O sponsors O National B-ORG Institute I-ORG on I-ORG Aging I-ORG R03AG056349 O SAEMF/EMF B-ORG GEMSSTAR I-ORG for I-ORG Emergency I-ORG Medicine I-ORG Supplemental I-ORG Funding I-ORG RF2017-010 O and O Agency B-ORG for I-ORG Healthcare I-ORG Research I-ORG and I-ORG Quality I-ORG T32 O HS000011-30 O These O grants O were O awarded O after O undergoing O peer O review O by O the O National O Institutes O of O Health O The O content O is O solely O the O responsibility O of O the O authors O and O does O not O reflect O the O official O views O of O the O National O Institutes O of O Health O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81973343 O 81673454 B-AWARD 81672608 B-AWARD 31801197 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Sun O Yat-sen O University O 19ykpy130 O 19ykzd24 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M643354 O Guangdong B-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Construction I-ORG Foundation I-ORG 2017B030314030 O Guangdong B-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Chiral I-ORG Molecule I-ORG and I-ORG Drug I-ORG Discovery I-ORG 2019B030301005 O C.-M.C.’s O research O is O supported O by O US O NIH B-ORG 1RO1CA251698-01 O CPRIT B-ORG RP180349 O RP190077 B-AWARD Welch B-ORG Foundation I-ORG I-1805 O Funding O for O open O access O charge O National O Natural O Science O Foundation O of O China O 81973343 O 81673454 O 81672608 O 31801197 O This O work O was O supported O by O grants O 084674/Z B-AWARD from O theWellcome O Trust O 336167 B-AWARD from O theEuropean O Research I-ORG Council O and O RYC-2015-17402 B-AWARD to O investigator O CT O from O the O SpanishMinistry O of I-ORG Economy I-ORG and I-ORG Competitiveness I-ORG This O study O was O supported O by O grants O from O the O Hundred B-ORG Talents I-ORG Program I-ORG of I-ORG Sun I-ORG Yat-sen I-ORG University I-ORG 392007 O NL O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81874176 O and O 82072766 B-AWARD NL; O 82201698 B-AWARD SW O Shenzhen B-ORG Sanming I-ORG Project I-ORG of I-ORG Medicine I-ORG SZSM201911003 O NL O Shenzhen B-ORG Science I-ORG Technology I-ORG and I-ORG Innovation I-ORG Commission I-ORG SZSTI I-ORG Basic I-ORG Research I-ORG Program I-ORG JCYJ20190809154411427 O and O JCYJ20220530145008018 B-AWARD NL; O No. O JCYJ20210324134800002 B-AWARD SW O and O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG 2020A1515110161 O JJ; O 2021A1515110891 B-AWARD SW O Australian B-ORG Research I-ORG Council O Grant/Award O Numbers O 160101380 B-AWARD 190101074 B-AWARD National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council O Grant/Award O Numbers O 1133840 B-AWARD 1136908 B-AWARD Wellcome B-ORG Trust O Grant/Award O Number O 208090/Z/17/Z B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81730108 O 31601062 B-AWARD and O 31771436 B-AWARD Major B-ORG Increase I-ORG Or I-ORG Decrease I-ORG Program I-ORG In I-ORG The I-ORG Central I-ORG Finance I-ORG Level I-ORG 2060302 O Key O Project O of O Zhejiang B-ORG Province I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2015C03055 O Key O Project O of O Hangzhou B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 20162013A07 O This O work O is O supported O by O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG no. O 2018AAA0102003 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O under O Grant O no. O 62006037 B-AWARD no. O 62172073 B-AWARD and O no. O U19B2039 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG no. O DUT22JC06 B-AWARD and O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG no. O 2022YFC3106101 B-AWARD This O work O was O supported O by O grants O from O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0100600 O Shanxi B-ORG Province I-ORG Research I-ORG Program I-ORG 201903D221075 O and I-AWARD 201901D211567 O and O Agricultural B-ORG Science I-ORG Research I-ORG of I-ORG Shanxi I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG YCX2020YQ34 O This O work O was O supported O by O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG of I-ORG “the I-ORG construction I-ORG of I-ORG the I-ORG Chengdu–Chongqing I-ORG economic I-ORG circle” I-ORG No. O KJCX2020050 B-AWARD Research B-ORG Foundation I-ORG of I-ORG Chongqing I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG No. O ckrc2020025 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 51778097 B-AWARD 52178458 B-AWARD Innovation B-ORG Program I-ORG for I-ORG Graduate I-ORG Students I-ORG of I-ORG Chongqing I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG No. O YKJCX2220604 B-AWARD No. O YKJCX2220605 B-AWARD The B-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Program I-ORG of I-ORG Chongqing I-ORG Municipal I-ORG Education I-ORG Commission I-ORG Grant O No. O KJQN202201518 B-AWARD This O research O was O supported O by O a O grant O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFE0203200 O XQ O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31600127 O KL O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG China I-ORG QC2016042 O KL) O and O Modern B-ORG Agroindustry I-ORG Technology I-ORG Research I-ORG System I-ORG in I-ORG China I-ORG nycytx-42-G3-01 O XW O The O funder O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O authors O gratefully O acknowledge O the O financial O support O of O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 51705319 B-AWARD Shanghai O Pujiang O Program O Grant O No. O 17PJ1403800 O and O Shanghai B-ORG Academy I-ORG of I-ORG Spaceflight I-ORG Technology I-ORG Grant O No. O SAST2017-060 B-AWARD The O work O is O also O partly O sponsored O by O the O Research O Project O of O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Mechanical I-ORG System I-ORG and I-ORG Vibration I-ORG Grant O No. O MSVZD201704 B-AWARD This O research O was O funded O by O the O Major B-ORG Research I-ORG Plan I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO.31690093 O the O Creative B-ORG Research I-ORG Groups I-ORG of I-ORG China I-ORG 31621005 O and O Zhengzhou B-ORG University I-ORG 32410196 O The O funding O agencies O played O no O part O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Top O Discipline O Construction O Project O of O Pratacultural B-ORG Science I-ORG NXYLXK2017A01 O the O Chinese B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2015M580896 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31660143 O 41501094 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Z.H O Wang O acknowledges O financial O support O from O the O China O Scholarship O Council O for O his O overseas O PhD O study O Contract O No. O 201606080030 O This O work O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 51672039 B-AWARD the O Fund B-ORG of I-ORG the I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Advanced I-ORG Technologies I-ORG for I-ORG Comprehensive I-ORG Utilization I-ORG of I-ORG Platinum I-ORG Metals I-ORG SKL-SPM-201505 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grants O No. O N160206001 B-AWARD N160204008 B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81770483 B-AWARD the B-ORG 14th I-ORG “Six I-ORG Talents I-ORG Peaks” I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG WSW-054 O Young B-ORG Medical I-ORG Talents I-ORG Supported I-ORG by I-ORG Jiangsu I-ORG Provincial I-ORG Improving I-ORG Medical I-ORG and I-ORG Health I-ORG Care I-ORG by I-ORG Science I-ORG and I-ORG Education I-ORG Program I-ORG QNRC2016861 O and O the B-ORG Fifth I-ORG Gusu I-ORG Health I-ORG Talents I-ORG Program I-ORG of I-ORG Suzhou I-ORG City I-ORG GSWS2019038 O B.A O was O supported O by O the B-ORG German I-ORG Research I-ORG Foundation I-ORG grant O no. O AK B-AWARD 42/10-1 I-AWARD and O AK B-AWARD 42/7-1 O and O the O German B-ORG Cancer I-ORG Aid I-ORG grant O no. O 70112727 B-AWARD D.H O was O supported O by O the O Wilhelm B-ORG Sander-Stiftung I-ORG grant O no. O 2018.093.1 B-AWARD and O 2018.093.2 B-AWARD This O study O was O funded O by O TDR/WHO B-ORG 201460655 O to O DG O and O supported O in O part O by O NIH-NIAID B-ORG U19AI089681 O to O JMV O and O NIH B-ORG R01(AI110112 O to O JEC O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Scientific B-ORG Startup I-ORG Foundation I-ORG for I-ORG Doctors I-ORG of I-ORG Northwest I-ORG A I-ORG and I-ORG F I-ORG University I-ORG Z109021604 O Basal B-ORG Research I-ORG Foundation I-ORG of I-ORG Northwest I-ORG A I-ORG and I-ORG F I-ORG University I-ORG Z109021612 O and O the O Modern B-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG of I-ORG China I-ORG No. O CARS-26-18 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31772529 B-AWARD the O Grant B-ORG Key I-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BE2016353 O China O and O U.S B-ORG Department I-ORG of I-ORG Energy I-ORG DOE I-ORG EERE I-ORG Awards I-ORG DE-EE0007104 O and O DE-EE0006112 B-AWARD with O the O Bioproducts O Science O O Engineering O Laboratory O and O Department O of O Biological O Systems O Engineering O at O Washington O State O University O This O project O was O supported O by O grants O from O the O 863 B-ORG program I-ORG 2013AA100604 O the O International O Consortium O for O Sugarcane O Biotechnology O EBI B-ORG BP2012OO2J17 B-AWARD and O US B-ORG DOE I-ORG DE-SC0010686 B-AWARD This O work O was O supported O by O the B-ORG Research I-ORG Fund I-ORG for I-ORG the I-ORG Doctoral I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG of I-ORG China I-ORG 20131403110005 O to O GX O Shanxi B-ORG Scholarship I-ORG Council I-ORG of I-ORG China I-ORG 2015-065 O to O SL O and O Basic B-ORG Theory I-ORG Innovation I-ORG Project I-ORG of I-ORG Shanxi I-ORG Agricultural I-ORG University I-ORG K4614144 O to O HC O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 51905253 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG of O China O Grant O No. O 2018A030310132 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Shenzhen I-ORG Municipality I-ORG of O China O Grant O No. O JCYJ20190809152401680 B-AWARD The O project O described O was O supported O by O the O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health O grant O number O R01MH104400 B-AWARD and O the O National O Center O for O Research O Resources O grant O number O UL1 O RR025752 O now O at O the O National B-ORG Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences O and O the O National O Cancer O Institute O grant O number O KM1 B-AWARD CA156726 O Effort O by O JB, O DB, O and O RS O was O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG grant O IIP-1034990 B-AWARD The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O NIH O This O work O was O supported O by O National B-ORG key I-ORG research I-ORG and I-ORG development I-ORG program I-ORG of I-ORG China I-ORG during I-ORG the I-ORG 13th I-ORG Five-Year I-ORG Plan I-ORG Period I-ORG 2016YFC1300700 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81301004 O and O Key B-ORG Program I-ORG of I-ORG Shanghai I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG Foundation I-ORG 13411950300 O This O work O was O supported O by: O Spanish B-ORG Economy I-ORG and I-ORG Competitiveness I-ORG Ministry I-ORG and I-ORG European I-ORG Regional I-ORG Development I-ORG Fund I-ORG through O the O IMMOEN O project O “Implementation O of O automated O calibration O and O multiobjective O optimization O techniques O applied O to O Building O Energy O Model O simulations O by O means O of O monitored O buildings” O Project O reference O ENE2015-65999-C2-2-R B-AWARD MINECO/FEDER O European B-ORG Commission I-ORG through O the O A2PBEER O project O “Affordable O and O Adaptable O Public O Buildings O through O Energy O Efficient O Retrofitting” O Grant O agreement O No O 609060 B-AWARD Laboratory O for O the O Quality O Control O of O Buildings O LCCE O of O the O Basque O Government O University B-ORG of I-ORG the I-ORG Basque I-ORG Country I-ORG UPV/EHU O Framework O agreement O Euro-regional O Campus O of O Excellence O within O the O context O of O their O respective O excellence O projects O Euskampus O and O IdEx O Bordeaux O Funder O reference O PIFBUR B-AWARD 16/26 I-AWARD National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21974142 O National B-ORG Major I-ORG Scientific I-ORG and I-ORG Technological I-ORG Special I-ORG Project I-ORG for O ‘Significant O New O Drugs O Development’ O 2018ZX09J18112 O National O Science O Foundation O of O China O 21571180 O 61605221 B-AWARD Nature B-ORG Science I-ORG Research I-ORG Project I-ORG of I-ORG Anhui I-ORG Province I-ORG 1908085QB65 O Sci-tech B-ORG Police I-ORG Project I-ORG of I-ORG Anhui I-ORG Province I-ORG 1804d08020308 O This O research O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31572446 O the B-ORG China I-ORG Modern I-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-41 O and O the B-ORG Collaborative I-ORG Innovation I-ORG Project I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences O CAAS-463 B-AWARD XTCX2016011-04-5 I-AWARD http://www.nsfc.gov.cn/english/site_1 O to O HL. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81425018 O No. B-AWARD 81672868 O the O Sci-Tech B-ORG Project I-ORG Foundation I-ORG of I-ORG Guangzhou I-ORG City I-ORG 201707020039 O the O Sun B-ORG Yat-sen I-ORG University I-ORG Clinical I-ORG Research I-ORG 5010 I-ORG Program I-ORG No. O 2019023 O the O Special B-ORG Support I-ORG Plan I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2014TX01R145 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholar I-ORG No. O 2018B030306001 O and O the O Pearl B-ORG River I-ORG S&T I-ORG Nova I-ORG Program I-ORG of I-ORG Guangzhou I-ORG No. O 201806010135 O This O research O was O funded O by O the O Center B-ORG for I-ORG Biodiversity I-ORG and I-ORG Conservation I-ORG at I-ORG the I-ORG American I-ORG Museum I-ORG of I-ORG Natural I-ORG History I-ORG AMNH O the O U.S O National O Science O Foundation O grant O numbers O NSF-CHE-1313908 B-AWARD and O NSF-BCS-1926215 B-AWARD the O Margot B-ORG Marsh I-ORG Biodiversity I-ORG Foundation O the O Eppley O Foundation O for O Research O the O Disney O Worldwide O Conservation O Fund O and O the O USAID O PEER O Science O Program O grant O number O 3-149 B-AWARD Additional O support O for O laboratory O work O and O research O interns O was O provided O by O Vietnam B-ORG National I-ORG University I-ORG Nguyen O T.H O Van O the O Institute O for O Comparative O Genomics O at O AMNH O G. O Amato O R. O DeSalle O and O the O AMNH O REU O Site O Program O NSF-DBI-0850543 O 1358465 B-AWARD S. O Perkins O Any O opinions O findings O conclusions O or O recommendations O expressed O in O this O material O are O those O of O the O author(s O and O do O not O necessarily O reflect O the O views O of O the O U.S O National O Science O Foundation O This O research O was O funded O by O the B-ORG National I-ORG Natural I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81350027 B-AWARD the B-ORG Major I-ORG Team I-ORG Project I-ORG of I-ORG Guangdong I-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2014A030312012 O and O the B-ORG Major I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG Guangzhou I-ORG 201508020258 O This O work O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO. O 61775163 B-AWARD Director B-ORG Fund I-ORG of I-ORG Qingdao I-ORG National I-ORG Laboratory I-ORG for I-ORG Marine I-ORG Science I-ORG and I-ORG Technology I-ORG NO. O QNLM201717 B-AWARD Young O Elite O Scientists O Sponsorship O Program O by O CAST O NO. O 2017QNRC001 B-AWARD National O Instrumentation O Program O NO. O 2013YQ030915 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG NO. O 2016M601260 B-AWARD This O work O was O supported O by O State’s B-ORG Key I-ORG Project I-ORG of I-ORG Research I-ORG and I-ORG Development I-ORG Plan O No. O 2016YFD0200900 B-AWARD Peng O Yu O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O No. O 31672317 B-AWARD Peng O Yu O and O the O Competitive O Planning O Projects O of O Hubei B-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences O No. O 2016jzxjh012 B-AWARD Peng O Yu O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 11071053 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG A2014207010 O Key B-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Research I-ORG of I-ORG Hebei I-ORG Educational I-ORG Department I-ORG ZD2016024 O Key B-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Research I-ORG of I-ORG Hebei I-ORG University I-ORG of I-ORG Economics I-ORG and I-ORG Business I-ORG 2016KYZ07 O Youth B-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Research I-ORG of I-ORG Hebei I-ORG University I-ORG of I-ORG Economics I-ORG and I-ORG Business I-ORG 2017KYQ09 O and O Youth B-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Research I-ORG of I-ORG Hebei I-ORG Educational I-ORG Department I-ORG QN2017328 O This O work O was O supported O by O contract O 2019-DI-43 B-AWARD of O the O Industrial B-ORG Doctorate I-ORG Program I-ORG of I-ORG the I-ORG Government I-ORG of I-ORG Catalonia O Project O PID2020-113614RB-C22 B-AWARD was O funded O by O the O Spanish B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Innovation O Some O authors O are O members O of O the O 2014-SGR163 B-AWARD research O group O funded O by O the O Generalitat B-ORG de I-ORG Catalunya I-ORG This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG 2018J01701 O the O Earmarked B-ORG Fund I-ORG for I-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-19 O the O Special B-ORG Fund I-ORG Project I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG of I-ORG Fujian I-ORG Agriculture I-ORG and I-ORG Forestry I-ORG University I-ORG KF2015055 O CXZX2017164 I-AWARD and I-AWARD CXZX2018069 O the O Rural B-ORG Revitalization I-ORG Tea I-ORG Industry I-ORG Technical I-ORG Service I-ORG Project I-ORG of I-ORG Fujian I-ORG Agriculture I-ORG and I-ORG Forestry I-ORG University I-ORG 11899170102 O the O Construction B-ORG of I-ORG Plateau I-ORG Discipline I-ORG of I-ORG Fujian I-ORG Province I-ORG 102/71201801101 O and O the O Scientific B-ORG Research I-ORG Foundation I-ORG of I-ORG Horticulture I-ORG College I-ORG of I-ORG Fujian I-ORG Agriculture I-ORG and I-ORG Forestry I-ORG University I-ORG 2019B01 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51804077 O Program O for O Guangdong O Introducing O Innovative O and O Entrepreneurial O Teams O No. O 2017ZT07G264 B-AWARD Shenzhen B-ORG Peacock I-ORG Plan I-ORG No. O KQTD2017033114582189 B-AWARD Shenzhen O Science O and O Technology O Innovation O Committee O JCYJ20170817152743178 O Excellent B-ORG Scientific I-ORG Research I-ORG Talent I-ORG Cultivation I-ORG Fund I-ORG of I-ORG Northeast I-ORG Petroleum I-ORG SJQHB201803 O This O research O was O funded O by O Dirección B-ORG General I-ORG de I-ORG Asuntos I-ORG del I-ORG Personal I-ORG Académico I-ORG UNAM O PAPIIT B-AWARD IN222621 I-AWARD and O IN213723 B-AWARD and O Facultad B-ORG de I-ORG Química I-ORG UNAM O PAIP B-AWARD 50009115 I-AWARD and O by O the O US B-ORG National I-ORG Science I-ORG Foundation I-ORG grant O B-AWARD MCB I-AWARD 1818297 I-AWARD to O E.B.C O This O work O was O supported O by O the O Autism O Imaging O Multicentre O Study O Consortium O funded O byMedical O Research I-ORG Council I-ORG UKGrant O G0400061 O by O the O EU-AIMS O Consortium O receiving O support O fromthe O Innovative I-ORG Medicines I-ORG InitiativeJoint O Undertaking O under O grant O agreement O no.115300 O which O includes O financial O contributions O fromthe O European I-ORG Union I-ORG Seventh I-ORG Framework I-ORG Programme(FP7/2007-2013 O from O the O European O Federation O of O Pharmaceutical O Industries O and O Associations O companies O in O kind O and O from O Autism O Speaks O Funding O to O pay O the O Open O Access O publication O charges O for O this O article O was O provided O by O MRC O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31570220 O Hubei B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 956 I-AWARD 2019CFB275 O and O Bureau B-ORG of I-ORG Landscaping I-ORG and I-ORG Forestry I-ORG of I-ORG Wuhan I-ORG Municipal I-ORG No. O 2018-28 O This O work O was O supported O by O the O Slovak B-ORG Research I-ORG and I-ORG Development I-ORG Agency I-ORG under O contracts O No. O APVV-0016-11 B-AWARD APVV-15-0086 B-AWARD and O APVV-17-0384 B-AWARD VEGA B-ORG Grant I-ORG Agency I-ORG of I-ORG the I-ORG Slovak I-ORG Republic I-ORG grants O No. O 2/0108/17 B-AWARD 1/0043/18 B-AWARD and O 2/0053/19 B-AWARD and O the O Ministry B-ORG of I-ORG Health I-ORG of I-ORG the I-ORG Slovak I-ORG Republic I-ORG grant O No. O 2019/57-BMCSAV-1 B-AWARD The O funding O bodies O played O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O The O sponsors O played O no O direct O role O in O the O study O This O work O was O supported O by O doctorate B-ORG program I-ORG funding I-ORG of I-ORG Hebei I-ORG Normal I-ORG University O Hebei O Province O China O grant O number O 130401 B-AWARD Biology B-ORG postdoctoral I-ORG Science I-ORG Foundation I-ORG of I-ORG Heibei I-ORG Normal I-ORG University I-ORG grant O number O 183717 B-AWARD and O Natural B-ORG Science I-ORG Foundation I-ORG Youth I-ORG Project I-ORG of I-ORG Hebei I-ORG province I-ORG C2017325001 O The O funders O had O no O role O in O study O design O in O the O collection O analysis O and O interpretation O of O data O in O the O writing O the O manuscript O or O in O the O decision O to O submit O the O article O for O publication O This O study O was O supported O by O the B-ORG Chongqing I-ORG Youth I-ORG High-end I-ORG Talent I-ORG Studio I-ORG Grant O No. B-AWARD ZQNYXGDRCGZS2021008 O the B-ORG Joint I-ORG Medical I-ORG Research I-ORG Programs I-ORG of I-ORG Chongqing I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG and I-ORG Health I-ORG Commission I-ORG Foundation I-ORG No. O 2022QNXM018 O and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2021CDJYGRH-012 O awarded O to O Dr. O Wuquan O Deng O and O Dr. O Min O Wang O Chongqing B-ORG medical I-ORG scientific I-ORG research I-ORG project I-ORG Joint O project O of O Chongqing O Health O Commission O and O Science O and O Technology O Bureau O 2020FYYX241 O awarded O to O Dr. O Xiaoyan O Jiang O This O study O is O also O partially O supported O by O National B-ORG Institutes I-ORG of I-ORG Health I-ORG National I-ORG Institute I-ORG of I-ORG Diabetes I-ORG and I-ORG Digestive I-ORG and I-ORG Kidney I-ORG Diseases I-ORG 1R01124789-01A1 O and O National B-ORG Science I-ORG Foundation I-ORG NSF I-ORG Center I-ORG to I-ORG Stream I-ORG Healthcare I-ORG in I-ORG Place I-ORG #C2SHiP B-AWARD CNS I-AWARD 2052578 I-AWARD awarded O to O Prof O Armstrong O DG. O This O study O was O supported O by O the B-ORG Important I-ORG Science I-ORG I-ORG Technology I-ORG Specific I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG for I-ORG Selective I-ORG Breeding I-ORG 2016C02055-8 O and O K. O C. O Wong O Magna O Fund O in O Ningbo O University O the B-ORG Spark I-ORG Plan I-ORG Project I-ORG in I-ORG Fujian I-ORG Province I-ORG No. O 2016S0055 B-AWARD and O the B-ORG Xiamen I-ORG Southern I-ORG Oceanographic I-ORG Center I-ORG No. O 14GZY56HJ26 B-AWARD Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo-FAPESP I-ORG FAPESP O 2019/26854-2 B-AWARD 2014/22689-3 B-AWARD 2019/21807-6 B-AWARD Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq–Bolsa O Produtividade O em O Pesquisa O 314166/2021-1 B-AWARD and O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG Capes O code B-AWARD 1. I-AWARD This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 41606174 B-AWARD 81673350 B-AWARD 41830535 B-AWARD the O Marine O S&T O Fund O of O Shandong O Province O for O Pilot O National O Laboratory O for O Marine O Science O and O Technology O Qingdao O China O No. O 2018SDKJ0406-5 O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG China I-ORG No. O 201762017 B-AWARD Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O ZR2017BD009 B-AWARD and O the O High O Performance O Computer O Center O of O Hebei O University O and O the O Taishan O Scholars O Program O China O This O study O was O sponsored O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 31702072 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Non-profit I-ORG Research I-ORG Institution I-ORG of I-ORG CAF I-ORG CAFYBB2017QA012 O and O the O Special B-ORG Fund I-ORG for I-ORG Forest I-ORG Scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Welfare I-ORG of I-ORG China I-ORG 201504305 O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Agence B-ORG Nationale I-ORG de I-ORG la I-ORG Recherche O HANC B-AWARD ANR-15-CE36-0005 O Institut B-ORG Universitaire I-ORG de I-ORG France O 2019 B-AWARD Centre B-ORG National I-ORG de I-ORG la I-ORG Recherche I-ORG Scientifique O Défi B-AWARD S2C3 O Conseil O Régional O d’Alsace O 2016 O This O work O was O supported O bySun O Yat-Sen I-ORG University(grant O number O “Five O I-AWARD Five” I-AWARD project O theNational O Nature I-ORG Scientific I-ORG Foundation(grant O number O 81071366 B-AWARD and O theScientific O and I-ORG Technological I-ORG Bureau I-ORG of I-ORG Guangzhou I-ORG Guangdong I-ORG Province(grant O number O 201508020059 B-AWARD China O This O research O was O supported O by O funding O from O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Inner I-ORG Mongolia I-ORG 2015MS0509 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC1200400 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018T110132 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41501426 O This O work O was O financially O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O U1605253 B-AWARD 61575043 B-AWARD and O 21327001 B-AWARD the O Startup B-ORG Science I-ORG Research I-ORG Foundation I-ORG for I-ORG High-level I-ORG Talents I-ORG of I-ORG Fujian I-ORG Medical I-ORG University I-ORG No. O XRCZX2017031 B-AWARD and O the O Startup B-ORG Fund I-ORG for I-ORG Scientific I-ORG Research I-ORG of I-ORG Fujian I-ORG Medical I-ORG University I-ORG No. O 2017XQ1017 B-AWARD The O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31730067 O 31571776 O and O 31501419 B-AWARD and O the O project B-ORG of I-ORG outstanding I-ORG scientific I-ORG and I-ORG technological I-ORG innovation I-ORG group I-ORG of I-ORG Jiangsu I-ORG Province I-ORG supported O us O in O the O design O of O the O study O and O writing O the O manuscript O The O 111 B-ORG Project I-ORG No. O 111-2-06 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG JUSRP51706A O and O the O key B-ORG research I-ORG and I-ORG development I-ORG program I-ORG social I-ORG development I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BE2015751 O supported O us O in O the O collection O analysis O and O interpretation O of O data O This O work O is O part O of O Ph.D O thesis O by O María O José O Jiménez-Quesada O and O was O supported O byEuropean O Regional I-ORG Development I-ORG Fund(ERDF O co-funded O projects O BFU2011-22779 B-AWARD BFU2016-77243-P B-AWARD RTC-2015-4181-2 B-AWARD and O RTC-2016-4824-2 B-AWARD SpanishMINECO O P2011-CVI-7487 B-AWARD Junta O de I-ORG Andalucía O and O 201540E065 B-AWARD CSIC O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31500037 O Guangdong B-ORG Provincial I-ORG Special I-ORG Fund I-ORG for I-ORG Marine I-ORG Economic I-ORG Development I-ORG Project I-ORG Yue O Natural O Resources O Contract O No. O GDNRC B-AWARD 2021]054 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG province I-ORG 2019A1515011829 O 2019A1515011702 B-AWARD This O study O was O supported O by O grants O from O the B-ORG National I-ORG Youthful I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81802340 O the B-ORG National I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81470868 O 81672379 B-AWARD the B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG of I-ORG China I-ORG ZR2016HM16 O the B-ORG Project I-ORG of I-ORG Invigorating I-ORG Health I-ORG Care I-ORG through I-ORG Science I-ORG Technology I-ORG and I-ORG Education I-ORG Jiangsu I-ORG Provincial I-ORG Medical I-ORG Youth I-ORG Talent I-ORG QNRC2016723 O Suzhou B-ORG Gusu I-ORG Medical I-ORG Youth I-ORG Talent I-ORG GSWS2019032 O These O funding O bodies O had O no O role O in O the O design O of O the O study O extraction O analysis O and O interpretation O of O data O or O in O writing O the O manuscript O This O work O was O supported O by O grants O from O the B-ORG National I-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 863 O Program O No. O 2011AA100606 O the B-ORG Innovation I-ORG fund I-ORG for I-ORG medium-sized I-ORG and I-ORG small I-ORG enterprises I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 13C26212201223 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31501366 O the B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Project I-ORG of I-ORG Jilin I-ORG provice I-ORG No. O 20150623024TC-11,20170520089JH O This O study O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFA0103700 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81770257 O 81600218 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20170002 O Natural O Science O Foundation O for O Colleges O and O Universities O in O Jiangsu O Province O 17KJA310006 O Suzhou O Municipal O Science O and O Technology O Foundation O SYS201675 O National O Clinical O Key O Specialty O of O cardiovascular O surgery O Jiangsu O Clinical O Research O Center O for O Cardiovascular O Surgery O Jiangsu O Province’s O Key O Discipline/Laboratory O of O Medicine O XK201118 O and O National O Center O for O International O Research O 2017B01012 O This O work O was O supported O by O the B-ORG Chinese I-ORG National I-ORG Key I-ORG Technology I-ORG Support I-ORG Program I-ORG 2015BAD15B05 O the B-ORG Chinese I-ORG National I-ORG Nature I-ORG Science I-ORG Foundation I-ORG 31571949 O and O the B-ORG Chinese I-ORG National I-ORG Programs I-ORG for I-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG 2012AA10180402 O This O study O was O funded O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O numbers O 62027901 B-AWARD 82272111 I-AWARD 92159303 I-AWARD 81901868 I-AWARD and I-AWARD 82072098 O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O No. O 7212207 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No. O 2572018BU03 B-AWARD and O the B-ORG project I-ORG of I-ORG high-level I-ORG talent I-ORG team I-ORG introduction I-ORG in I-ORG Zhuhai I-ORG City I-ORG Zhuhai O HLHPTP201703 O This O work O was O supported O by O Office B-ORG of I-ORG Naval I-ORG Research I-ORG Multidisciplinary I-ORG University I-ORG Research I-ORG Initiative I-ORG Grant I-ORG N000141612829 O National B-ORG Institutes I-ORG of I-ORG Health I-ORG Grants O R01 O EB009282 I-AWARD and I-AWARD R01 I-AWARD MH099645 O and O National B-ORG Science I-ORG Foundation I-ORG Grant O IIS-1724405 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51674006 B-AWARD and O the O Anhui B-ORG University I-ORG discipline I-ORG professional I-ORG talented I-ORG person I-ORG No. O gxbjZD09 B-AWARD Anhui O Provincial O Natural O Science O Foundation O Youth O Project O 1908085QE185 O Anhui O Provincial O College O of O Natural O Science O Research O Key O Project O KJ2018A0098 O Project O funded O by O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M642502 O and O the O Science O Research O Foundation O for O Young O Teachers O in O Anhui O University O of O Science O and O Technology O QN2017211 O This O study O was O supported O by O a O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O grant O funded O by O the O Korea O government O MSIT O NRF-2019R1A2C3002924 O and O by O the O Bio&Medical O Technology O Development O Program O 2017M3A9G7073521 O M-S O Lee O is O the O recipient O of O Korea B-ORG Drug I-ORG Development I-ORG Fund I-ORG from O the O Ministry O of O Science O O ICT O Ministry O of O Trade O Industry O O Energy O and O Ministry O of O Health O O Welfare O HN22C0278 O and O a O grant O from O the O Faculty O Research O Assistance O Program O of O Soonchunhyang B-ORG University I-ORG 20220346 O XHL O received O funds O for O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG Grant O No. O 15ZR1444300.http://www.stcsm.gov.cn/sj/app.htm B-AWARD WCB O received O funds O from O CAPES B-ORG Special O Visiting O Reseacher O Program O Grant O 170/2012 B-AWARD that O enabled O RAW O to O work O in O his O laboratory O http://www.capes.gov.br O and O a O Newton O Fund O grant O APQ-00829-15 B-AWARD through O the O BBSRC/Fapemig O joint O initiative O held O with O Dr. O Peter O Ashton O University O of O York O and O Prof O R O Beynon O Liverpool O University O http://www.newtonfund.ac.uk O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31802172 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20170492 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2016M590510 O Jiangsu O Co-innovation O Center O for O Prevention O and O Control O of O Important O Animal O Infectious O Diseases O and O Zoonoses O and O the O Priority O Academic O Program O Development O of O Jiangsu O Higher O Education O Institutions O PAPD O TN O was O supported O by O MEXT B-ORG KAKENHI I-ORG The O Ministry O of O Education,Culture,Sports,Science O and O Technology;http://www.mext.go.jp/en O 23128505 O 25128706 I-AWARD 16H01452 I-AWARD and I-AWARD 18H04766)and O NIBB O Cooperative O Research O Programs O 18-433 O DE O was O supported O by O NSF B-ORG IOS I-ORG Integrative O Organismal O Systems O National O Science O Foundation;https://www.nsf.gov/div/index.jsp?div=IOS O 0919781 O RZ O was O supported O by O an O NSF/JSPS B-ORG EAPSI I-ORG fellowship I-ORG East O Asia O and O Pacific O Summer O Institutes O for O U.S O Graduate O Students;https://www.nsf.gov/pubs/2013/nsf13593/nsf13593.htm O 1311025 O and O an O NIH B-ORG PERT I-ORG Post-doctoral I-ORG fellowship I-ORG NIH-Training O Program O Postdoctoral O Excellence O in O Research O and O Teaching;http://cis.arl.arizona.edu/Pert/postdoctoral-positions-available-research-associate-arizona-research-laboratories-university O 2K12GM000708-16 O LL O was O funded O by O NSF O IOS O Integrative O Organismal O Systems O National O Science O Foundation;https://www.nsf.gov/div/index.jsp?div=IOS O 0919730 O and O the O National B-ORG Institute I-ORG of I-ORG Food I-ORG and I-ORG Agriculture I-ORG U.S I-ORG Department I-ORG of I-ORG Agriculture I-ORG Hatch I-ORG Project I-ORG 1001738 O The O roles O of O these O funders O are O the O study O design O data O collection O and O analysis O and O preparation O of O the O manuscript O This O work O is O financially O supported O by O the O Technology B-ORG and I-ORG Basic I-ORG and I-ORG Frontier I-ORG Research I-ORG Program I-ORG of I-ORG Chongqing I-ORG Municipality I-ORG cstc2018jcyjAX0701 B-AWARD and I-AWARD cstc2017jcyjAX0326 O and O Major B-ORG Program I-ORG of I-ORG Chongqing I-ORG University I-ORG of I-ORG Arts I-ORG and I-ORG Sciences I-ORG P2017XC06 B-AWARD the B-ORG Open I-ORG Project I-ORG Program I-ORG from I-ORG Chongqing I-ORG Key I-ORG Laboratory I-ORG of I-ORG Micro/Nano I-ORG Materials I-ORG Engineering I-ORG KF201605 B-AWARD the B-ORG Open I-ORG Project I-ORG Fund I-ORG of I-ORG Chongqing I-ORG University I-ORG New I-ORG Energy I-ORG Storage I-ORG Devices I-ORG and I-ORG Application I-ORG Engineering I-ORG Research I-ORG Center I-ORG KF20170105 B-AWARD and O the B-ORG Postgraduate I-ORG Research I-ORG Project I-ORG Fund I-ORG of I-ORG Chongqing I-ORG University I-ORG of I-ORG Arts I-ORG and I-ORG Sciences I-ORG M2017ME07 B-AWARD This O research O was O funded O by O the B-ORG Regional I-ORG Government I-ORG of I-ORG Madrid I-ORG through I-ORG the I-ORG program I-ORG ADITIMAT I-ORG ref O P2018/NMT-4411 B-AWARD and O CIBERINFEC-CIBER B-ORG of I-ORG Infectious I-ORG Diseases I-ORG CB21/13/00043 O B.T O would O like O to O thank O the B-ORG Spanish I-ORG Ministry I-ORG of I-ORG Education I-ORG Culture I-ORG and I-ORG Sports I-ORG for O the O support O through O the O FPU O grant O FPU17/05977 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 12202448 B-AWARD High-level B-ORG Innovation I-ORG Research I-ORG Institute I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2020 B-AWARD B0909010003 O and O Research B-ORG Project I-ORG of I-ORG Guangdong I-ORG Aerospace I-ORG Research I-ORG Academy I-ORG GARA2022001000 O This O study O was O supported O by O the O Israel B-ORG Cancer I-ORG Association I-ORG ICA O No. O 0394691 O the O Israel B-ORG Foundation I-ORG of I-ORG Science I-ORG ISF O No. O 0394883 B-AWARD and O the O Israel B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG MOST O grant O agreement O 0394906 O The O funders O had O no O role O in O study O design O data O collection O and O interpretation O or O the O decision O to O submit O the O work O for O publication O This O work O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 61601006 B-AWARD Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No:4192021 O the O Equipment B-ORG Pre-Research I-ORG Foundation I-ORG 61404130312 O the O youth O top-notch O talent O training O program O of O NCUT O Yuxiu O talent O training O program O of O NCUT O This O work O was O supported O by O grants O from O the O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG CIFMS O 2016-I2M-3-016 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 31370327 B-AWARD and I-AWARD 81603225 O the O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O No. O 5152021 B-AWARD and O PUMC B-ORG Youth I-ORG Fund I-ORG and I-ORG the I-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No. O 3332016072 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG General O Program O Grant O No. O 51875240 B-AWARD the O Fund B-ORG Project I-ORG in I-ORG Equipment I-ORG Pre-research I-ORG Field I-ORG Grant O No. O 61400040403 B-AWARD the O China O Postdoctoral O Science O Foundation O funded O project O Grant O No. O 2018M630324 B-AWARD the O Special O Industrialization O Demonstration O project O New O Material O Special O Project O of O Jilin O province O and O school O co-construction O plan O Grant O No. O SXGJSF2017-3 O the O Major O Scientific O and O Technological O Project O of O Changchun O Grant O No.17SS023 O and O the O Department B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Jilin I-ORG Province I-ORG Grant O No. O 20190103114JH B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81172118 B-AWARD 81201793 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Henan I-ORG Province I-ORG No. O 162300410304 B-AWARD Foundation B-ORG and I-ORG Frontier I-ORG Technology I-ORG Research I-ORG Project I-ORG of I-ORG Henan I-ORG Province I-ORG No. O 142300410325 B-AWARD This O work O was O supported O by O funding O awarded O to O Dr. O Cheng O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82073191 O The B-ORG Innovative I-ORG Research I-ORG Team I-ORG of I-ORG High-level I-ORG Local I-ORG Universities I-ORG in I-ORG Shanghai I-ORG SHSMU-ZLCX20212302 O and O the O Clinical B-ORG Research I-ORG Plan I-ORG of I-ORG SHDC I-ORG SHDC2022CRD025 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 12104354 B-AWARD 62075177 B-AWARD 62105251 B-AWARD the O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG 2020A1515110590 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG XJS210504 O XJS210503 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 2021JQ-184 O 023JCQN0731 B-AWARD 2023JCYB518 B-AWARD the O Key B-ORG industry I-ORG innovation I-ORG chain I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 2020ZDLSF04-09 O and O the O Open B-ORG Research I-ORG Fund I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Transient I-ORG Optics I-ORG and I-ORG Photonics I-ORG and I-ORG Key I-ORG Laboratory I-ORG of I-ORG Image I-ORG Processing I-ORG and I-ORG Pattern I-ORG Recognition I-ORG Nanchang I-ORG Hangkong I-ORG University I-ORG ET202080417 O WBE B-ORG Liver I-ORG Fibrosis I-ORG Foundation I-ORG No. O CFHPC20161005 B-AWARD International B-ORG Cooperative I-ORG Project I-ORG of I-ORG Anhui I-ORG Province I-ORG No. O 1704e1002231 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O WK9110000048 B-AWARD This O research O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31772083 O 31772889 B-AWARD Special O fund O for O Technology O Innovation O of O Hubei O Province O 2019AHB07 O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC1600100 O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2662017JC040 O 2662016QD010 B-AWARD China B-ORG Scholarship I-ORG Council I-ORG 201806765004 O and O the O National O Innovation O and O Entrepreneurship O Training O Program O for O Undergraduates O 2020BC203 O S202010504215 O S201910504071 O 201810504087 O This O project O was O supported O by O the O grant O of O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81573750/81473491/81173395/H2902 O the B-ORG Young I-ORG and I-ORG Middle-Aged I-ORG University I-ORG Discipline I-ORG Leaders I-ORG of I-ORG Zhejiang I-ORG Province I-ORG China I-ORG 2013277 O Zhejiang B-ORG Provincial I-ORG Program I-ORG for I-ORG the I-ORG Cultivation I-ORG of I-ORG High-level I-ORG Health I-ORG talents I-ORG 2015 O This O paper O is O supported O by O the O National O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O NO. O 51578207 I-AWARD 51678211 O the O Fundamental O Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities O NO. O JZ2017HGTB0209 O and O Anhui O Science I-ORG and I-ORG Technology I-ORG Project I-ORG I-ORG Sci-tech I-ORG Police O NO. O 1704d0802189 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O European B-ORG Union I-ORG 765492 O Spanish B-ORG Government I-ORG AGL2017-88702-C2-2-R O to O M.H O Consejería O de O Economía O Conocimiento O Empresas O y O Universidad O de O la O Junta O de O Andalucía O and O European O Regional O Development O Funds O ERDF O SOMM17-6109 O UCE-PP2017-3 B-AWARD to O J.A.M O and O M.H O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III O ERDF O funds O PIE16/00045 O to O J.A.M O Chair O ‘Doctors O Galera-Requena O in O cancer O stem O cell O research’ O to O J.A.M O Instituto O de O Salud O Carlos O III O IFI16/00041 O to O E.A O Funding O for O open O access O charges O Excellence O Research O Unit O “Modelling O Nature O MNat O SOMM17-6109 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31800564 O the O University B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG Shanxi I-ORG Province I-ORG 2019L0392 O the O Excellent B-ORG Doctoral I-ORG Program I-ORG of I-ORG Shanxi I-ORG Province I-ORG SXYBKY201727 O and O the O Funding B-ORG for I-ORG Doctoral I-ORG Research I-ORG of I-ORG Shanxi I-ORG Agricultural I-ORG University I-ORG 2017YJ21 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31371157 O 81300193 B-AWARD 81570332 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20171482 O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG for I-ORG Young I-ORG Scholars I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20130887 O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Higher I-ORG Education I-ORG Institutions I-ORG of I-ORG Jiangsu I-ORG Province I-ORG 13KJB310002 O the B-ORG Science I-ORG and I-ORG Technology I-ORG Developmental I-ORG Foundation I-ORG of I-ORG Nanjing I-ORG Medical I-ORG University I-ORG 2012NJMU017 O the B-ORG grant I-ORG from I-ORG Jiangsu I-ORG Province’s I-ORG Key I-ORG Provincial I-ORG Talent I-ORG Program I-ORG ZDRCA2016019 O to I-AWARD L.Z O the O Start-up O Foundation O of O Nanjing O Medical O University O to O J.W O and O a O project O funded O by O the O Priority O Academic O Program O Development O of O Jiangsu O Higher O Education O Institutions O PAPD O This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81502853 B-AWARD 81473028 B-AWARD 81473029 B-AWARD 81773499 B-AWARD and O 81703273 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O BK20151026 B-AWARD and O BK20171054 B-AWARD the O Jiangsu B-ORG Province I-ORG Medical I-ORG Young I-ORG Talent I-ORG No.QNRC2016616 O and O the B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Fund I-ORG Key I-ORG Project I-ORG of I-ORG Nanjing I-ORG Medical I-ORG University I-ORG No. O 2016NJMUZD012 B-AWARD This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31271817 O 31301101 B-AWARD the O Key B-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Anhui I-ORG 1501031099 O the O Anhui B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG 1408085QF106 O the O Specialized B-ORG Research I-ORG Fund I-ORG for I-ORG the I-ORG Doctoral I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG 20133401120011 O and O the O Technology O Foundation O for O Selected O Overseas O Chinese O Scholars O from O Department B-ORG of I-ORG Human I-ORG Resources I-ORG and I-ORG Social I-ORG Security I-ORG of I-ORG Anhui I-ORG Province I-ORG No. O 2014]-243 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O authors O gratefully O acknowledge O the O financial O support O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51873042 B-AWARD No. O 21808039 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2018A030310525 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2017B090915004 B-AWARD and O the O Guangdong O Provincial O Key O Laboratory O of O Advanced O Coatings O Research O and O Development O No. O 2017B030314105 O S.M O was O funded O by O an O STFC B-ORG Aurora I-ORG studentship I-ORG grant O ST/1506102/1 B-AWARD and O the O NASA B-ORG Astrobiology I-ORG Institute I-ORG Program I-ORG on O Foundations O of O Complex O Life O Evolution O Preservation O and O Detection O on O Earth O and O Beyond O grant O NNA13AA90A B-AWARD J.P O was O supported O by O NERC B-ORG grant O NE/G00322X/l B-AWARD Our O study O protocol O underwent O full O external O peer-review O during O funding O process O which O was O carried O out O by O China O Cardiovascular O Association O home O pagehttps://www.ccahouse.org/index.html O In O line O with O the O principle O of O fairness O and O justice O the O expert O jury O conducted O a O letter O review O and O then O a O total O of O 33 O contestants O were O shortlisted O for O the O interview O according O to O the O score O ranking O All O review O experts O were O independent O from O the O authors O This O work O was O finally O supported O by O China B-ORG Cardiovascular I-ORG Association-Cardiac I-ORG Rehabilitation I-ORG and I-ORG Metabolic I-ORG Therapy I-ORG research I-ORG fund I-ORG No. O CCA-CRMT-1712 O Young B-ORG Talents I-ORG Project I-ORG of I-ORG Medical I-ORG and I-ORG Health I-ORG Research I-ORG in I-ORG Zhejiang I-ORG Province I-ORG No. O 2019RC188 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG LY18H020007 O The O funders O were O not O involved O in O study O design O and O in O writing O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31801745 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Chongqing O China O cstc2019jcyj-msxmX0403 O and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG XDJK2017C067 O This O project O was O supported O in O part O by O grant O VTM-1 B-AWARD from O the O Veterinary O Translational O Medicine O program O of O the O Clinical B-ORG and I-ORG Translational I-ORG Science I-ORG Institutes I-ORG of I-ORG the I-ORG University I-ORG of I-ORG Minnesota I-ORG and I-ORG Indiana I-ORG University I-ORG and O by O grants O UL1 B-AWARD RR033183 I-AWARD University O of O Minnesota O Clinical O and O Translational O Science O Award O P30 B-AWARD CA077598 I-AWARD Comprehensive O Cancer O Center O Support O Grant O Masonic B-ORG Cancer I-ORG Center I-ORG University I-ORG of I-ORG Minnesota I-ORG for O support O of O the O Comparative O Pathology O Shared O Resource O the O Flow O Cytometry O Shared O Resource O and O the O Clinical O Pharmacology O Analytical O Services O and O P30 B-AWARD CA023168 I-AWARD Purdue O Center I-ORG for I-ORG Cancer I-ORG Research I-ORG for O use O of O the O Purdue O Flow O Cytometry O and O Cell O Separation O Shared O Resource O and O UL1 B-AWARD TR001108 I-AWARD from O the O National B-ORG Institutes I-ORG of I-ORG Health O National O Center O for O Advancing O Translational O Sciences O supporting O the O Indiana O University O and O Purdue O University O Clinical O and O Translational O Sciences O Institute O from O the O National O Institutes O of O Health O Clinical O grade O valspodar O was O provided O for O this O study O by O Novartis O Pharma O AG. O Dr. O Daisuke O Ito O was O supported O in O part O by O a O FIRST O Award O from O Morris B-ORG Animal I-ORG Foundation I-ORG D12CA-302 O The O authors O gratefully O acknowledge O donations O to O the O Animal O Cancer O Care O and O Research O Program O of O the O University O of O Minnesota O that O helped O support O this O project O This O research O was O funded O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2021YFB2800902 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61931010 O 62105111 B-AWARD Hubei B-ORG Province I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2021BAA008 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG HUST O 2021XXJS026 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG 2021CFB049 O and O the O State O Key B-ORG Laboratory I-ORG of I-ORG Advanced I-ORG Optical I-ORG Communication I-ORG Systems I-ORG and I-ORG Networks I-ORG China I-ORG 2022GZKF022 O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 31760425 B-AWARD Foundation B-ORG of I-ORG Science I-ORG I-ORG Technology I-ORG department I-ORG of I-ORG Sichuan I-ORG Province O China O grant O number O 16JC022 B-AWARD National B-ORG General I-ORG Cultivation I-ORG Project I-ORG of I-ORG China I-ORG West I-ORG Normal I-ORG University I-ORG grant O number O 17C043 B-AWARD and O the O Innovation O Team O Project O of O Education O Department O of O Sichuan O Province O Grant O No. O 16TD0020 O Each O of O the O funding O bodies O granted O the O funds O based O on O a O research O proposal O They O had O no O role O in O the O design O of O the O study O collection O analysis O and O interpretation O of O data O or O in O writing O the O manuscript O This O work O was O supported O by O an O Irish B-ORG Research I-ORG Council I-ORG Employment O Based O Postgraduate O Scholarship O EBP/2017/473 O KS O a O British O Pharmacological O Society O Schachter O Award O KS) O and O funding O from O Breakthrough O Cancer O Research O KS O and O BNK O This O project O area O has O received O funding O from O the O European O Union’s O Horizon B-ORG 2020 I-ORG research O and O innovation O programme O under O grant O agreement O no. O 734907 B-AWARD RISE/3D-NEONET I-AWARD project I-AWARD BNK O Automated O image O analysis O work O was O supported O by O the O Science B-ORG Foundation I-ORG Ireland I-ORG Investigator O Programme O OPTi-PREDICT O grant O code O 15/IA/3104 B-AWARD WMG O AR) O and O the O Science O Foundation O Ireland O Strategic O Partnership O Programme O Precision O Oncology O Ireland O POI O grant O code O 18/SPP/3522 B-AWARD WMG O AR O The O authors O are O grateful O to O the O financial O support O for O this O work O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31770621 O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Pulp I-ORG and I-ORG Paper I-ORG Engineering I-ORG No. O 2016TS03 B-AWARD 201836 O Guangdong B-ORG Province I-ORG Science I-ORG Foundation I-ORG for O Cultivating O National O Engineering O Research O Center O for O Efficient O Utilization O of O Plant O Fibers O 2017B090903003 O and O Natural O Science O Foundation O of O Guangdong O Province O of O China O 2018A030313840 O This O research O was O funded O by O Canada O Research O Chair O CRC O program O the O Leading O Edge O Endowment O Fund O LEEF O The O National B-ORG Science I-ORG Fund I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG 81925020 O The O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFB1300302 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81630051 B-AWARD 91648122 B-AWARD 81601565 B-AWARD and O Tianjin O Key O Technology O R&D O Program O No. O 17ZXRGGX00020 O 16ZXHLSY00270 O This O research O was O supported O by O Guangxi B-ORG Colleges I-ORG and I-ORG Universities I-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Projects I-ORG Project O number O KY2015LX054 B-AWARD Youth O Science I-ORG Foundation I-ORG of I-ORG Guangxi I-ORG Medical I-ORG University I-ORG Project O number O GXMUYSF201643 B-AWARD Humanities B-ORG base I-ORG project I-ORG of I-ORG Guangxi I-ORG Medical I-ORG University I-ORG Project O number O 2016RWB04 B-AWARD and O Innovation B-ORG Project I-ORG of I-ORG Guangxi I-ORG Graduate I-ORG Education I-ORG Project O number O YCBZ2017041 B-AWARD This O work O was O jointly O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD1000600 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32070376 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of O China O 2662018JC046 O and O the O Key O Technology O of O Safety O Production O to O Improve O Tea O Quality O and O Efficiency O in O Three O Gorges O Reservoir O Area O The O funder O had O no O role O in O the O design O determination O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O in O part O by O grants O from O the B-ORG Special I-ORG Fund I-ORG for I-ORG Forest I-ORG Scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Welfare I-ORG No. O 201404420 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Fund I-ORG of I-ORG China I-ORG Nos O 31372220 B-AWARD 31672313 O Science B-ORG and I-ORG technology I-ORG research I-ORG plan I-ORG of I-ORG Shandong I-ORG Province I-ORG No. O 2013GSF11707 B-AWARD This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFA0403103 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 22172189 O and O 22121002 B-AWARD the O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG QYZDY-SSW-SLH013 O the O Program B-ORG of I-ORG Shanghai I-ORG Academic I-ORG Research I-ORG Leader I-ORG 22XD1424100 O and O the O Research B-ORG Funds I-ORG of I-ORG Happiness I-ORG Flower I-ORG ECNU I-ORG 2020ST2203 O This O work O was O supported O by O the B-ORG Sichuan I-ORG Province I-ORG Academic I-ORG and I-ORG Technical I-ORG Leaders I-ORG Cultivate I-ORG Support I-ORG Funds I-ORG the I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG for I-ORG Public I-ORG Wellbeing I-ORG of I-ORG Chengdu I-ORG grant O number O 2014-HM01-00107-SF B-AWARD the B-ORG Key I-ORG Project I-ORG of I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Sichuan I-ORG Province I-ORG grant O number O 2018SZ0078 B-AWARD the B-ORG Research I-ORG funds I-ORG of I-ORG Chengdu I-ORG science I-ORG and I-ORG technology I-ORG office I-ORG grant O number O 2015-HM01-00347-SF B-AWARD and O the B-ORG Research I-ORG funds I-ORG of I-ORG Sichuan I-ORG traditional I-ORG Chinese I-ORG medicine I-ORG administration I-ORG grant O number O 2016Q040 B-AWARD This O article O was O supported O by O The B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC1306300 O 2016YFC0103000 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O 61633018 B-AWARD 81522021 B-AWARD 81430037 B-AWARD 81471731 B-AWARD 31371007 O Beijing B-ORG Nature I-ORG Science I-ORG Foundation I-ORG 7161009 O and O Beijing B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG PXM2019_026283_000002 O This O academic O study O received O financial O support O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Project O number O 81871373 B-AWARD the O Support B-ORG Programs I-ORG for I-ORG Young I-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG Talents I-ORG of I-ORG Shenyang I-ORG Project O number O RC170557 B-AWARD and O the O Youth B-ORG Project I-ORG of I-ORG Basic I-ORG Scientific I-ORG Research I-ORG for I-ORG Colleges I-ORG and I-ORG Universities I-ORG in I-ORG Liaoning I-ORG Province I-ORG Project O number O LQNK201701 B-AWARD This O work O was O supported O by O the O National B-ORG Cancer I-ORG Institute I-ORG through O N01 B-AWARD PC-064402 I-AWARD TobPRAC O PGS O and O DKH O and O by O the O National B-ORG Cancer I-ORG Institute I-ORG and I-ORG the I-ORG FDA I-ORG Center I-ORG for I-ORG Tobacco I-ORG Products I-ORG through O R01 B-AWARD CA I-AWARD 203851 I-AWARD SSH O and O DKH O Mass O spectrometry O was O carried O out O in O the O Analytical O Biochemistry O Core O Facility O of O the O Masonic O Cancer O Center O supported O in O part O by O National B-ORG Cancer I-ORG Institute I-ORG Cancer I-ORG Center I-ORG Support I-ORG Grant I-ORG CA-077598 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O NIH O or O the O Food O and O Drug O Administration O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81573374 B-AWARD 21807052 B-AWARD Hunan O Engineering O Research O Centre O for O Optimisation B-ORG of I-ORG Drug I-ORG Formulation I-ORG and I-ORG Early I-ORG Clinical I-ORG Evaluation I-ORG Grant O No. O 2015TP2005 B-AWARD Jiangxi B-ORG Outstanding I-ORG Youth I-ORG Talent I-ORG Support I-ORG Programme I-ORG Grant O No. O 20192BCB23018 B-AWARD and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG China I-ORG Grant O No. O 20192ACBL21034 B-AWARD This O work O was O financially O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31672215 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0200100 O and I-AWARD 2017YFD0200103 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG China I-ORG 2662019PY013 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O is O supported O by O the O HICoE O grant O for O CISIR O 0153CA-005 O Ministry B-ORG of I-ORG Education I-ORG MOE I-ORG Malaysia O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61572076 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant I-ORG No. O 2015M570940 O and O the O BIT B-ORG Fundamental I-ORG Research I-ORG Grant I-ORG No. O 20150442009 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2014CB954100 O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG the I-ORG People's I-ORG Republic I-ORG of I-ORG China I-ORG 2012FY110800 O and O the O Applied B-ORG Fundamental I-ORG Research I-ORG Foundation I-ORG of I-ORG Yunnan I-ORG Province I-ORG 2014GA003 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG Grant O number O 2016YFD0400200 B-AWARD the B-ORG Youth I-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG Talents I-ORG Cultivation I-ORG Plant I-ORG in I-ORG Agricultural I-ORG Sector I-ORG of I-ORG Liaoning I-ORG Province I-ORG China I-ORG Grant O number O 2014041 B-AWARD and O the B-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Key I-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG of I-ORG Shenyang I-ORG Liaoning I-ORG Province I-ORG China I-ORG Grant O number O 2017-171267 B-AWARD Research O in O the O authors’ O laboratory O is O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31670311 O and I-AWARD 31701052 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG 2018J01602 O Distinguished O Young O Scholars O Fund O in O Fujian B-ORG Agriculture I-ORG and I-ORG Forestry I-ORG University I-ORG xjq201609 O and O the O Open O Project O Program O of O State O Key O Laboratory O of O Molecular O Developmental O Biology O 2016-MDB-KF-12 O The O study O was O accomplished O with O the O financial O support O of O Academy B-ORG of I-ORG Finland I-ORG Flagship O Programme O PREIN O decision O 320166 O and O grant O 343393 B-AWARD Horizon B-ORG 2020 I-ORG RISE I-ORG DiSeTCom I-ORG Project O No. O 823728 B-AWARD and O Horizon B-ORG Europe I-ORG FLORIN I-ORG Project O No. O 101086142 B-AWARD This O research O was O funded O by O a O Doctoral O Dissertation O Research O Improvement O Grant O BCS-0746009 B-AWARD from O the O National B-ORG Science I-ORG Foundation I-ORG to O R.P.M O and O A.S O Autism B-ORG Speaks I-ORG Predoctoral O Fellowship O 4721 O to O A.S O grant O 1F32-DC0011219 B-AWARD from O the O National B-ORG Institute I-ORG on I-ORG Deafness I-ORG and I-ORG Other I-ORG Communication I-ORG Disorders I-ORG to O A.S O and O a O Dean’s O Scholar O Award O from O the O College O of O Arts O and O Sciences O and O Miami O University O to O K.R O This O project O was O supported O in O part O with O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O 81302226 O the B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG the I-ORG Jilin I-ORG Province I-ORG 20130101164JC O and O 20140414059GH B-AWARD the B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Jilin I-ORG Province I-ORG Education I-ORG Department I-ORG 2014200 O 20132070 B-AWARD The O content O of O this O publication O does O not O necessarily O reflect O the O views O or O policies O of O the O Department O of O Health O and O Human O Services O nor O does O mention O of O trade O names O commercial O products O or O organizations O imply O endorsement O by O the O Chinese O Government O This O research O was O funded O by O the O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG grant O no. O 2021A1515010805 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 32171200 B-AWARD and O the O Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG grant O no. O JCYJ20220530115210023 B-AWARD This O study O was O funded O by O a O Wellcome B-ORG Trust I-ORG strategic O award O Ref O 085417/Z/08/Z B-AWARD website:https://wellcome.ac.uk O MH O was O funded O during O this O study O as O an O Academic O Clinical O Lecturer O by O the O National O Institute O for O Health O Research O UK O website:https://www.nihr.ac.uk O LG O was O funded O during O this O study O by O a O Child B-ORG Health I-ORG Research I-ORG Charitable I-ORG Incorporated I-ORG Organisation I-ORG grant O Ref O 521297 B-AWARD website:https://www.ucl.ac.uk/ich/about-us/cio/cio-overview O and O the O Medical B-ORG Research I-ORG Council I-ORG Ref O G81174H B-AWARD website:https://www.mrc.ac.uk O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O Melbourne O WHO O Collaborating O Centre O for O Reference O and O Research O on O Influenza O is O supported O by O the O Australian O Department O of O Health O E.C.H O is O funded O by O an O ARC B-ORG Australian I-ORG Laureate I-ORG Fellowship I-ORG FL170100022 O J.H.O.P O is O supported O by O the O Swedish B-ORG research I-ORG council I-ORG FORMAS I-ORG grant O 2015-710 B-AWARD N.L O is O supported O by O an O ARC B-ORG Future I-ORG Fellowship I-ORG FT160100463 O This O work O was O founded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81602065 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG of I-ORG China I-ORG BE2017626 O and O the O Foundation B-ORG of I-ORG Wuxi I-ORG Health I-ORG Commission I-ORG QNRC003 O This O study O was O authorized O and O financially O supported O by O the O Shanghai B-ORG Municipal I-ORG Government I-ORG 15GWZK1002 O and O the O National B-ORG Key I-ORG Technology I-ORG R&D I-ORG Program I-ORG during I-ORG the I-ORG Thirteenth I-ORG Five-year I-ORG Plan I-ORG Period I-ORG 2017YFC0111800 O Dr O Yi O Zhang O was O supported O by O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81670377 O and O the O Shanghai B-ORG Excellent I-ORG Young I-ORG Scholars I-ORG Program I-ORG 2017YQ065 O The O work O was O supported O by O grant O from O the O National B-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG of I-ORG China I-ORG Nos.81603093 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG China I-ORG Nos.2015J01354 O and O the O Open B-ORG Research I-ORG Fund I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Cellular I-ORG Stress I-ORG Biology I-ORG Xiamen I-ORG University I-ORG Nos.SKLCSB2019KF016 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81302454 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG 2016D025 O the O Special B-ORG Fund I-ORG for I-ORG Clinical I-ORG and I-ORG Scientific I-ORG Research I-ORG of I-ORG Chinese I-ORG Medical I-ORG Association I-ORG 18010360765 O and O the O Xiamen B-ORG medical I-ORG advantage I-ORG subspecialty I-ORG construction I-ORG project I-ORG 2018296 O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O National O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant/award O number O 31772832 O National O Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China O grant/award O number O 2019YFD0900603 O Hunan O Provincial I-ORG Modern I-ORG Agricultural I-ORG Research I-ORG System O grant/award O number O 2019-105 O This O research O was O funded O by O grants O from O the O analysis B-ORG on I-ORG the I-ORG genetic I-ORG mechanism I-ORG of I-ORG the I-ORG resistance I-ORG of I-ORG the I-ORG major I-ORG food I-ORG crops I-ORG to I-ORG the I-ORG pest I-ORG and I-ORG disease I-ORG 2022YFF1001500 O the O Core B-ORG Technology I-ORG Development I-ORG for I-ORG Breeding I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG JBGS-2021-014 O the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG of I-ORG MOF I-ORG and I-ORG MARA I-ORG No. O CARS-04 B-AWARD the O Jiangsu B-ORG Collaborative I-ORG Innovation I-ORG Center I-ORG for I-ORG Modern I-ORG Crop I-ORG Production I-ORG JCIC-MCP O Collaborative B-ORG Innovation I-ORG Center I-ORG for I-ORG Modern I-ORG Crop I-ORG Production I-ORG co-sponsored I-ORG by I-ORG Province I-ORG and I-ORG Ministry I-ORG CIC-MCP O This O work O was O supported O in O part O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG under O Grant O No.2019YJS015 O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O under O Grant O 61872029 B-AWARD and O in O part O by O the O Beijing B-ORG Municipal I-ORG Natural I-ORG Science I-ORG Foundation I-ORG under O Grant O 4182048 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 51675386 B-AWARD and I-AWARD 51775387 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFB1104900 B-AWARD and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG No. O 2018CFA091 B-AWARD This O work O was O funded O by O Iniciativa B-ORG Científica I-ORG Milenio I-ORG ICM O NC120027 B-AWARD Fondecyt B-ORG Grant O 1131008 B-AWARD and O Fondecyt B-ORG for I-ORG Iniciation I-ORG in I-ORG Research I-ORG Grant O 11150721 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O funded O by O the O Ministry O of O Science O ICT O O Future O Planning O NRF-2016R1C1B2016275 O S.K.L O was O supported O by O Dong-A B-ORG ST I-ORG 0620154110 O J.M O was O supported O by O Seoul B-ORG National I-ORG University I-ORG Hospital I-ORG 0420170820 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O is O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFE0107600 O the O Innovative B-ORG Research I-ORG Groups I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51621005 O and O the O National O Natural O Science O Foundation O of O China O 51706201 O This O work O was O supported O by O Science B-ORG and I-ORG Technology I-ORG Support I-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Sichuan I-ORG Province O Grant O ID: O 2016FZ0103 B-AWARD and O Key B-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Sichuan I-ORG Province O Grant O ID: O 2017SZ0067 B-AWARD and O 1.3.5 B-ORG project I-ORG for I-ORG disciplines I-ORG of I-ORG excellence I-ORG West I-ORG China I-ORG Hospital I-ORG Sichuan I-ORG University O Grant O ID: O ZY2016104 B-AWARD The O study O sponsor O had O no O role O in O the O design O and O conduct O of O the O study O collection O management O analysis O and O interpretation O of O the O data O preparation O review O or O approval O of O the O article O and O decision O to O submit O the O article O for O publication O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Project I-ORG 31501658 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0201305 O and O the O Special B-ORG Scientific I-ORG Research I-ORG Fund I-ORG of I-ORG Agricultural I-ORG Public I-ORG Welfare I-ORG Profession I-ORG of I-ORG China I-ORG 201403030 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O U21A20324 B-AWARD and O 22278167 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG Nos O 2022J01312 B-AWARD and O 2021J06026 B-AWARD and O Start-Up B-ORG Scientific I-ORG Research I-ORG Funds I-ORG for I-ORG Newly I-ORG Recruited I-ORG Talents I-ORG of I-ORG Huaqiao I-ORG University I-ORG No. O 605-50Y20015 B-AWARD This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81670451 B-AWARD 81470469 B-AWARD 81770430 B-AWARD 81870179 B-AWARD Shanghai B-ORG Rising-Star I-ORG Program I-ORG Grant O No. O 17QA1403000 B-AWARD Shanghai B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Grant O No. O 2018YQ17 B-AWARD This O work O was O supported O by O grants O from O the O Agence B-ORG Nationale I-ORG de I-ORG la I-ORG Recherche I-ORG ANR-13-BSV3-0010-04-Chemimmmun O and O used O the O platforms O of O the O Grenoble O Instruct O Centre O ISBG O UMS O 3518 O CNRS-CEA-UJF-EMBL O with O support O from O FRISBI O ANR-10-INSB-05-02 O and O GRAL O ANR-10-LABX-49-01 O within O the O Grenoble O Partnership O for O Structural O Biology O PSB O This O work O was O supported O by O grant O HL107152 B-AWARD from O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG to O U.R.D O The O VCU O group O thanks O the O computational O resource O provided O by O National B-ORG Center I-ORG for I-ORG Research I-ORG Resources I-ORG grant O S10 B-AWARD RR027411 O L.L O was O supported O by O a O grant O from O the O China O Scholarship O Council O This O research O was O funded O by O the O Fondo B-ORG de I-ORG Investigación I-ORG Sanitaria-IS I-ORG Carlos I-ORG III I-ORG ref O PI20/00923 B-AWARD REACT-EU-Comunidad B-ORG de I-ORG Madrid I-ORG and I-ORG the I-ORG European I-ORG Regional I-ORG Development I-ORG Fund I-ORG ref O SPACE2-CV-COVID-CM B-AWARD and O Ciberdem B-ORG ref O CB07/08/2007 B-AWARD This O work O was O supported O in O part O by O funding O from O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG No. O 2016YFC0206300 B-AWARD and O No. O 2015CB553402 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 21925702 B-AWARD No. O 31470532 B-AWARD No. O 91543102 B-AWARD No. O 31970111 B-AWARD No. O 31670118 B-AWARD and O No. O 81730102 B-AWARD the O Beijing B-ORG Nova I-ORG Program I-ORG No. O Z171100001117011 B-AWARD the O Tsinghua O University-Peking O University O Center O for O Life O Sciences O CLS O Tsinghua B-ORG University I-ORG Initiative I-ORG Scientific I-ORG Research I-ORG Program I-ORG No. O 20161080133 B-AWARD the O Beijing O Advanced O Innovation O Center O for O Structural O Biology O the O Beijing O Frontier O Research O Center O for O Biological O Structure O and O the O Tongji B-ORG University I-ORG Subject I-ORG Pilot I-ORG Program I-ORG No. O 162385 B-AWARD The O work O was O funded O by O the O National B-ORG Planning I-ORG Office I-ORG of I-ORG Philosophy I-ORG and I-ORG Social I-ORG Science I-ORG of O China O No. O 16FJY008 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 11801060 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG No. O ZR2016FM26 B-AWARD The O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O no. O 2016YFC1302603 B-AWARD Nanjing B-ORG University I-ORG Hospital I-ORG Management I-ORG Institute O grant/Award O Number O NDYG2016014 B-AWARD The B-ORG Clinical I-ORG Medical I-ORG Center I-ORG for I-ORG Digestive I-ORG Disease I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BL2012001 O Yan O Chan O was O supported O by O theNational O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China(31630036 O and O 81390350),Ministry B-AWARD of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China(2016YFA0500103),Chinese O Academy I-ORG of I-ORG Sciences(XDA12010102 O QYZDJ495 B-AWARD SSW-SMC008 O ZDRW-ZS-2016-8 B-AWARD Y817X11141 B-AWARD and I-AWARD CAS I-AWARD Interdisciplinary I-AWARD Innovation I-AWARD Team O This O research O work O was O supported O by O funding O received O from O the O Department B-ORG of I-ORG Biotechnology I-ORG DBT O Project O Id.BT/PR/4988/INF/22/155/2012 B-AWARD and O the O Department B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG DST-FIST O Project O Id. O SR/FST/LSI-470/2010 B-AWARD of O the O Ministry O of O Science O O Technology O Government O of O India O H.S O Chandak O and O S.P O Bahekar O are O thankful O to O UGC B-ORG New I-ORG Delhi I-ORG India I-ORG F. O No. I-AWARD 41-335/2012 I-AWARD SR) I-AWARD dt.13.07.2012 O for O the O financial O support O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC I-ORG 31172163 O Funds O for O Environment B-ORG Construction I-ORG I-ORG Capacity I-ORG Building I-ORG of I-ORG GDAS’ I-ORG Research I-ORG Platform I-ORG 2016GDASPT-0107 O and O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of O Guangzhou O city O China O 201510010036 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51509262 O 51579247 O the O Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG 2017JBF0104 O the O China B-ORG Three I-ORG Gorges I-ORG Corporation I-ORG project I-ORG 0799570 O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0900903 O and O the O Chongqing B-ORG Graduate I-ORG Student I-ORG Research I-ORG and I-ORG Innovation I-ORG Project I-ORG CYB18078 O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O is O supported O by O the O YES B-ORG project I-ORG YES-POCI-01-0247-FEDER-070135 O cofinanced O by O the O European O Regional O Development O Fund O ERDF O through O the O COMPETE O 2020-Incentive O System O to O Research O and O Technological O Development O within O the O Portugal O 2020 O Competitiveness O and O Internationalization O Operational O Program O This O research O is O also O supported O by O the O FoodNano B-ORG Sense I-ORG Bio-sensing I-ORG research I-ORG on I-ORG food I-ORG astringency I-ORG and I-ORG bitterness I-ORG of I-ORG natural I-ORG phenolics I-ORG project I-ORG with O the O grant O provided O by O PTCRIS O 145189 B-AWARD Mónica O Jesus O acknowledges O the O doctoral O fellowship O UI/BD/151275/2021 B-AWARD to O the O Associated B-ORG Laboratory I-ORG for I-ORG Sustainable I-ORG Chemistry I-ORG Clean I-ORG processes I-ORG and I-ORG Technologies I-ORG LAQV I-ORG The O current O study O was O supported O by O grants O from O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC1000404 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG General O Program O 81370735 B-AWARD the O National O Natural O Science O Foundation O of O China O General O Program O 81771610 B-AWARD and O the B-ORG Outstanding I-ORG Scientific I-ORG Fund I-ORG of I-ORG Shengjing I-ORG Hospital I-ORG 201706 O These O funding O bodies O played O a O role O in O protocol O development O and O did O not O play O any O role O in O data O collection O analysis O interpretation O of O data O or O writing O the O manuscript O The O data O collection O for O the O ITC O Project O is O supported O by O grants O from O US O National B-ORG Cancer I-ORG Institute I-ORG R01 O CA100362 O R01 B-AWARD CA090955 O and O P50 B-AWARD CA111236–Roswell O Park O Transdisciplinary O Tobacco O Use O Research O Center O and O P01 B-AWARD CA138389 O and O Robert B-ORG Wood I-ORG Johnson I-ORG Foundation I-ORG 045734 O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG MOP-57897 O MOP-79551 B-AWARD and O MOP-115016 B-AWARD Additional O support O was O provided O to O Geoffrey O T. O Fong O from O a O Senior O Investigator O Award O from O the O Ontario O Institute O for O Cancer O Research O and O a O Prevention O Scientist O Award O from O the O Canadian O Cancer O Society O Research O Institute O Additional O support O for O this O manuscript O was O provided O by O Canadian O Institutes O of O Health O Research O FDN-148477 O The O funding O sources O had O no O role O in O the O study O design O in O collection O analysis O and O interpretation O of O data O in O the O writing O of O the O article O or O in O the O decision O to O submit O the O paper O for O publication O This O research O is O supported O by O Hong B-ORG Kong I-ORG Baptist I-ORG University I-ORG FRG2/16-17/007 O FRG2/17-18/003 O the O Health B-ORG and I-ORG Medical I-ORG Research I-ORG Fund I-ORG HMRF/14150561 O the O Research B-ORG Grants I-ORG Council I-ORG HKBU/12301115 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21575121 O 21775131 I-AWARD 21628502 O the O Hong O Kong O Baptist O University O Century O Club O Sponsorship O Scheme O 2018 O the O Interdisciplinary O Research O Matching O Scheme O RC-IRMS/16-17/03 O Interdisciplinary O Research O Clusters O Matching O Scheme O RC-IRCs/17-18/03 O Innovation B-ORG and I-ORG Technology I-ORG Fund I-ORG ITS/260/16FX O Collaborative O Research O Fund O C5026-16G O Matching O Proof O of O Concept O Fund O MPCF-001-2017/18 O SKLEBA O and O HKBU O Strategic O Development O Fund O SKLP_1718_P04 O the O Science O and O Technology O Development O Fund O Macao O SAR O 0072/2018/A2 O the O University B-ORG of I-ORG Macau I-ORG MYRG2016-00151-ICMS-QRCM O and I-AWARD MYRG2018-00187-ICMS O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81572962 O the B-ORG Programme I-ORG of I-ORG Introducing I-ORG Talents I-ORG of I-ORG Discipline I-ORG to I-ORG Universities I-ORG B14035 O Innovation B-ORG Team I-ORG Development I-ORG Plan I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG No. O IRT_17R110 O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0902000 O the B-ORG Sun I-ORG Yat-Sen I-ORG University I-ORG Cultivating I-ORG Foundation I-ORG 16ykpy29 O This O study O was O supported O by O the O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 7164284 O Innovation B-ORG Science I-ORG Research I-ORG Foundation I-ORG of O 307th O Hospital O of O PLA O FC-2014-01 O Public B-ORG Health I-ORG Major I-ORG Project I-ORG AWS15J007 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O authors O are O grateful O to O the O Program B-ORG for I-ORG Leading I-ORG Talents I-ORG of I-ORG Hubei I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG L2018031 O and O the O Innovation B-ORG and I-ORG Application I-ORG of I-ORG Key I-ORG Technologies I-ORG of I-ORG Quality I-ORG improving I-ORG and I-ORG Efficiency-increasing I-ORG for I-ORG the I-ORG Fengtou I-ORG Ginger I-ORG Industry I-ORG 2020-620-002-06 O The O authors O also O gratefully O acknowledge O the O partial O support O from O Hubei B-ORG Agricultural I-ORG Science I-ORG Innovation I-ORG Center I-ORG 2021-620-000-001-027 O and O Hubei B-ORG Biopesticide I-ORG Engineering I-ORG Research I-ORG Centre I-ORG HBERC-RC-202002 O HBERC-RC-202104 B-AWARD This O work O was O supported O by O Grant O Number O R01LM011986 B-AWARD from O the O National B-ORG Library I-ORG of I-ORG Medicine I-ORG NLM O Grant O Number O R01GM122845 B-AWARD from O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG NIGMS O and O Grand O Number O R01AD057555 B-AWARD of O National B-ORG Institute I-ORG of I-ORG Aging I-ORG of I-ORG the I-ORG National I-ORG Institute I-ORG of I-ORG Health I-ORG NIH O as O well O as O CUNY O High O Performance O Computing O Center O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81272601 B-AWARD 81472198 B-AWARD and O 81672307 B-AWARD the O Key B-ORG Clinical I-ORG Medicine I-ORG Technology I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O BL2014096 B-AWARD the O Medical B-ORG Key I-ORG Talented I-ORG Person I-ORG Foundation I-ORG of I-ORG the I-ORG Jiangsu I-ORG Provincial I-ORG Developing I-ORG Health I-ORG Project I-ORG No. O RC2011080 B-AWARD the O Innovation O Team O Project O of O the O Second O Affiliated O Hospital O of O Nanjing O Medical O University O and O the O “333 O high I-ORG class I-ORG Talented I-ORG Man I-ORG Project” O No. O 2011-III-2630 B-AWARD This O work O was O financially O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFA0605100 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31370398 O 31270701 B-AWARD and O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Earth I-ORG Surface I-ORG Processes I-ORG and I-ORG Resource I-ORG Ecology I-ORG 2017-FX-05 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O the O United B-ORG States I-ORG US) I-ORG Defense I-ORG Threat I-ORG Reduction I-ORG Agency I-ORG HDTRA1-15-1-0054 O and O by O the O financial O assistance O award O 70NANB22H017 B-AWARD from O US B-ORG Department I-ORG of I-ORG Commerce I-ORG DOC O National O Institute O of O Standards O and O Technology O NIST O Bruker O UltraFlextreme O MALDI O TOF/TOF O was O funded O by O NIH B-ORG grant O No. O S10OD018913 B-AWARD Thermo O Q-Exactive O HF O High-field O Orbitrap O was O funded O by O NIH O grant O No. O S10OD025271 B-AWARD The O contents O of O this O publication O are O solely O the O responsibility O of O the O authors O and O do O not O necessarily O represent O the O official O view O of O DTRA O DOC O NIST O or O NIH O The O funding O sponsors O had O no O role O in O the O design O of O the O study O in O the O collection O analyses O or O interpretation O of O data O in O the O wiring O of O the O manuscript O and O in O the O decision O to O publish O the O results O This O study O was O supported O by O the O Uppsala-Örebro B-ORG Regional I-ORG Research I-ORG Council I-ORG RFR-651021 O and I-AWARD RFR-744511 O the O Erik B-ORG Karin I-ORG and I-ORG Gösta I-ORG Selander I-ORG Foundation I-ORG and O the O Scandinavian B-ORG Society I-ORG for I-ORG Antimicrobial I-ORG Chemotherapy I-ORG SLS-692951 O This O work O was O supported O by O the O Schweizerischer B-ORG Nationalfonds I-ORG zur I-ORG Förderung I-ORG der I-ORG Wissenschaftlichen I-ORG Forschung I-ORG 407040_153952 O Horizon B-ORG 2020 I-ORG Framework I-ORG Programme I-ORG 641004 O Swiss B-ORG State I-ORG Secretary I-ORG for I-ORG Education I-ORG Research I-ORG and I-ORG Innovation I-ORG 15.0158,17.00105 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O No. O 52006201 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG General I-ORG Program O grant O number O No. O 52275295 B-AWARD the B-ORG Innovation I-ORG Leadership I-ORG Project I-ORG of I-ORG Yancheng I-ORG Jiangsu I-ORG Province O grant O number O YW O 2020 B-AWARD No. I-AWARD 40; O the O Industry O University O Research O Cooperation O Plan O Project O of O Zhengzhou O City O grant O number O ZKH O 2020 B-AWARD No. I-AWARD 3; O Key B-ORG scientific I-ORG research I-ORG projects I-ORG of I-ORG colleges I-ORG and I-ORG universities I-ORG in I-ORG Henan I-ORG province O grant O number O No. O 23A460001 B-AWARD MRB O received O a O PRODOC O grant O from O CAPES B-ORG project O 2599/2010 B-AWARD RBL O is O supported O by O fellowships O from O CNPq/MCT B-ORG 141823/2011–9 O MRP O is O supported O by O grant O from O CNPq/MCT O 571334/2008–3 O Fieldwork O during O 2011 O and O 2012 O was O partially O funded O by O Fundação B-ORG Grupo I-ORG O I-ORG Boticário I-ORG de I-ORG Proteção I-ORG à I-ORG Natureza I-ORG trough O the O project O 0895_20111 B-AWARD conducted O by O Mater O Natura—Instituto O de O Estudos O Ambientais O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Parrotia-Stiftung O the O Swiss B-ORG Federal I-ORG Office I-ORG for I-ORG Health I-ORG 12.005187 O Swiss B-ORG State I-ORG Secretariat I-ORG for I-ORG Migration I-ORG 3a-12-0495 O Angela O Nickerson O was O supported O by O a O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG Clinical I-ORG Early I-ORG Career I-ORG Fellowship I-ORG 1037091 O Tobias O R. O Spiller O was O supported O by O the O Swiss O Study O Foundation O This O work O was O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. I-AWARD 81260257 I-AWARD 31460156 I-AWARD 31560179 O the O National B-ORG Sharing I-ORG Service I-ORG Platform I-ORG for I-ORG Parasite I-ORG Resources I-ORG TDRC-22 I-ORG the I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Province I-ORG 20171BAB214013 O and O the O Cooperation B-ORG Foundation I-ORG of I-ORG the I-ORG Key I-ORG Laboratory I-ORG of I-ORG Parasite I-ORG and I-ORG Vector I-ORG Biology I-ORG Ministry I-ORG of I-ORG Public I-ORG Health I-ORG WSBKTKT201708 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH O under O award O no. O RAI092531A B-AWARD to O JFB O This O work O was O supported O in O part O by O the O March B-ORG of I-ORG Dimes I-ORG Foundation I-ORG research O Grant O no. O 5-FY10-103 B-AWARD to O MJM O YS O work O was O supported O by O postdoctoral O fellowship O grant O no. O 2016-67012-24717 B-AWARD from O the O USDA O National B-ORG Institute I-ORG of I-ORG Food I-ORG and I-ORG Agriculture O The O funder O Enview O inc O provided O support O in O the O form O of O salaries O for O the O author O RS, O but O did O not O have O any O additional O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O specific O roles O of O these O authors O are O articulated O in O the O ‘author O contributions’ O section O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81601559 O and O 71701219 B-AWARD Guangdong O Provincial O Natural O Science O Foundation O of O China O 2016A030310233 O and O the O Humanities O and O Social O Sciences O Foundation O of O the O Ministry B-ORG of I-ORG Education I-ORG of I-ORG China I-ORG 16YJC190011 O This O work O was O supported O by O the O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG BB/F005806/1 O BB/K003097/1 B-AWARD the O Engineering B-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG EP/C544587/1 O to O DAR O and O the O European B-ORG Union I-ORG Seventh I-ORG Framework I-ORG Programme I-ORG FP7/2007-2013 O under O grant O agreement O n° O 305564 O This O work O was O supported O by O grants O from O Consejo B-ORG de I-ORG Seguridad I-ORG Nuclear I-ORG CSN O 2012-0001 O and O EURATOM B-ORG Dark.Risk O GA I-AWARD 323216 O to O AG. O The O authors O acknowledge O 2014-SGR-524 O grant O from O Generalitat O de O Catalu-nya O JC O is O supported O by O the O Asociacion O Española O Contra O el O Cancer O and O the O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III I-ORG CP13/00160 O LT O acknowledges O Ministerio O de O Economia O y O Competitividad O grant O SAF2013-43801-P O We O acknowledge O the O support O of O the O Great B-ORG Lakes I-ORG Fishery I-ORG Commission I-ORG over O the O years O as O group O grants O to O BZ O and O RD O GLFC O 54011 B-AWARD 54021 B-AWARD 54035 B-AWARD Group O Grants O provide O the O necessary O conditions O to O promote O in-depth O reviews O of O this O kind O This O work O was O also O supported O by O a O grant O to O RD O from O the O Natural B-ORG Sciences I-ORG and I-ORG Engineering I-ORG Research I-ORG Council I-ORG of I-ORG Canada I-ORG NSERC O 217435 B-AWARD a O grant O from O the O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG CIHR O 15129 B-AWARD and O a O group O grant O from O the O Fonds B-ORG de I-ORG Recherche I-ORG du I-ORG Québec I-ORG I-ORG Santé I-ORG FRQS O 5249 B-AWARD This O work O was O supported O by O a O grant O from O the O National B-ORG Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases I-ORG https://www.niaid.nih.gov O grant O AI B-AWARD 031478 I-AWARD to O MJL O and O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG http://www.nsfc.gov.cn/english/site_1/index.html O grant O 31830086 B-AWARD to O SW. O We O thank O the O Johns O Hopkins O Malaria O Research O Institute O mosquito O core O facility O for O help O with O mosquito O rearing O Additional O support O was O provided O by O the O Johns O Hopkins O Malaria O Research O Institute O and O the O Bloomberg O Philanthropies O Supply O of O human O blood O was O supported O by O National B-ORG Institutes I-ORG of I-ORG Health I-ORG https://www.nih.gov O Grant O RR00052 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG UK)(BB/H016902/1 O theVolkswagen O Foundation(Az O 85 I-AWARD 060 O and O theWellcome O Trust(101092/Z/13/Z O IL O held O a O Studentship O from O the O Volkswagen O Foundation O KK O and O HB O held O Royal O Society O University O Research O Fellowships O This O study O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31472203,31172342 B-AWARD the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG of I-ORG China I-ORG No. O 2013BAD12B05 B-AWARD National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG No.2016YFD0501102 O Genetically B-ORG Modified I-ORG Organisms I-ORG Breeding I-ORG Major I-ORG Projects I-ORG of I-ORG P.R I-ORG China I-ORG grant O No. O 2014ZX0801203B B-AWARD and O IAEA B-ORG CRP I-ORG No.17453 O The O funders O had O no O role O in O the O study O design O data O analysis O and O decision O to O publish O or O preparation O of O the O manuscript O M.P O would O like O to O acknowledge O Rosemere O Cancer O Foundation O for O funding O C.L.M.M O would O like O to O thank O Coordenação O de O Aperfeiçoamento O de O Pessoal O de O Nível O Superior O CAPES)—Brazil O ref O 88881.128982/2016-01 O for O financial O support O E.J.C O and O S.J.K O were O supported O through O a O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG NIHR O Clinician O Scientist O Fellowship O NIHR-CS-012-009 O N.A.J.R O was O supported O by O a O Medical B-ORG Research I-ORG Council I-ORG Doctoral O Research O Fellowship O MR/M018431/1 O V.N.S O was O supported O through O a O Wellcome B-ORG Trust/Wellbeing O of O Women O Research O Training O Fellowship O ref O 098670/Z/12/Z B-AWARD H.O O was O supported O through O an O NIHR O Academic O Clinical O Fellowship O M.L.M O and O A.E.D O were O supported O by O Manchester O University O Hospitals O NHS O Foundation O Trust O Clinical O Research O Fellowships O O.R O and O M.K O were O supported O by O Genesis B-ORG Research I-ORG Trust I-ORG P63522 O WSCR O This O article O presents O independent O research O partly O funded O by O the O NIHR O supported O by O the O NIHR O Manchester O Biomedical O Research O Centre O IS-BRC-1215-20007 O and O facilitated O by O the O Greater O Manchester O Local O Clinical O Research O Network O The O views O expressed O are O those O of O the O authors O and O not O necessarily O those O of O the O Wellcome O Trust O Wellbeing O of O Women O the O MRC O the O NHS O the O NIHR O or O the O Department O of O Health O This O work O was O supported O by O NRF O National O Research I-ORG Foundation I-ORG of I-ORG Korea O Grant O funded O by O the O Korean O Government O NRF-2017-Fostering O Core O Leaders O of O the O Future O Basic O Science O Program/Global O Ph.D O Fellowship O Program)(2017H1A2A1046377 O and O also O partially O supported O by O Jeon O Buk O Technopark O JBTP O grant O funded O by O Ministry B-ORG of I-ORG Science I-ORG and I-ORG ICT I-ORG MSIT O REDE O 2018 I-AWARD JB I-AWARD 001 O and O also O partially O supported O by O a O grant O of O the O Korea O Health O Technology O R O O D O Project O through O the O Korea B-ORG Health I-ORG Industry I-ORG Development I-ORG Institute I-ORG KHIDI O funded O by O the O Ministry O of O Health O O Welfare O Republic O of O Korea O HI19C0642 O This O research O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31790412 O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2015CB943103 O National B-ORG Transgenic I-ORG Breeding I-ORG Project I-ORG of I-ORG China I-ORG 2016ZX08010004 O the O Modern O Agro-industry O Technology O Research O Systems O of O China O CARS-37 O and O the O Project O for O Extramural O Scientists O of O State O Key O Laboratory O of O Agrobiotechnology O 2019SKLAB6-1 O This O work O was O supported O by O the O Breeding B-ORG Project I-ORG of I-ORG Shandong I-ORG Province I-ORG 2017LZN014 O the O Significant B-ORG Application I-ORG Projects I-ORG of I-ORG Agriculture I-ORG Technology I-ORG Innovation I-ORG in I-ORG Shandong I-ORG Province I-ORG SD2019ZZ010 O the O Technology B-ORG System I-ORG of I-ORG Modern I-ORG Agricultural I-ORG Industry I-ORG in I-ORG Shandong I-ORG Province I-ORG SDAIT-19-01 O the O Special B-ORG Foundation I-ORG for I-ORG Distinguished I-ORG Taishan I-ORG Scholar I-ORG of I-ORG Shandong I-ORG Province I-ORG ts201712057 O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG Shandong I-ORG province I-ORG 2019LYXZ009 O The O funds O played O no O role O in O study O design O data O analysis O and O manuscript O preparation O Sample O preparation O and O SNP O genotyping O were O supported O by O grants O from O the B-ORG 863 I-ORG State I-ORG High-tech I-ORG Development I-ORG Plan I-ORG 2013AA102503 O National B-ORG Natural I-ORG Science I-ORG Foundations I-ORG of I-ORG China I-ORG 31372293 O and O Shandong B-ORG Swine I-ORG Industry I-ORG Technology I-ORG System I-ORG Innovation I-ORG SDAIT-08-03 O Analysis O and O interpretation O of O data O and O the B-ORG Natural I-ORG Science I-ORG Foundations I-ORG of I-ORG Shandong I-ORG Province I-ORG of I-ORG China I-ORG ZR2017MC043 B-AWARD and O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG SAAS I-ORG CXGC2016A04 B-AWARD The O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81472427 B-AWARD No. O 81672574 B-AWARD No. O 81702547 B-AWARD the O Shanghai B-ORG Sailing I-ORG Program I-ORG No. O 17YF1415300 B-AWARD the O Shanghai B-ORG New I-ORG Frontier I-ORG Technology I-ORG Project I-ORG No. O SHDC12015110 B-AWARD and O the O Shanghai B-ORG Municipal I-ORG Medical I-ORG and I-ORG Health I-ORG Discipline I-ORG Construction I-ORG Projects I-ORG No. O 2017ZZ02015 B-AWARD This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82230005 O 81873432 O 82200133 B-AWARD 82200137 B-AWARD and O 82070143 O grants B-ORG from I-ORG the I-ORG Jiangsu I-ORG Province I-ORG of I-ORG China I-ORG BE2021645 O Translational B-ORG Research I-ORG Grant I-ORG of I-ORG NCRCH I-ORG 2021ZKMA01 O and O 2021ZKQA01 O and O the B-ORG Priority I-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O This O work O is O jointly O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG Grant O No. O 2018YFC0604404 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 51504010 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No. O PA2019GDPK0079 B-AWARD This O study O was O funded O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31701967 O the B-ORG Key I-ORG research I-ORG and I-ORG development I-ORG program I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2017C02018 O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG China I-ORG LQ17C150003 O and O the B-ORG young I-ORG talent I-ORG training I-ORG project I-ORG of I-ORG Zhejiang I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG 2016R23R08E05 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 11331009 O 11701528 B-AWARD Shanxi B-ORG Key I-ORG Laboratory I-ORG 201705D111006 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0501500 O and O Shanxi B-ORG Scientific I-ORG and I-ORG Technology I-ORG Innovation I-ORG Team I-ORG 201705D15111172 O This O work O was O supported O by O grants O from O Anhui B-ORG Provincial I-ORG Financial I-ORG Agricultural I-ORG Germplasm I-ORG Resources I-ORG Protection I-ORG and I-ORG Utilization I-ORG Fund I-ORG Project I-ORG Anhui I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG Key I-ORG Laboratory I-ORG Project I-ORG No. O 2021YL023 B-AWARD Anhui B-ORG Province I-ORG Academic I-ORG and I-ORG Technical I-ORG Leader I-ORG Candidate I-ORG Project I-ORG No. O 2022H300 B-AWARD Anhui B-ORG Province I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Youth I-ORG Fund I-ORG Project I-ORG 2108085QC135 O and O the O Special B-ORG Fund I-ORG for I-ORG Anhui I-ORG Agricultural I-ORG Research I-ORG System I-ORG AHCYJSTX-05-12 O AHCYJSTX-05-23 B-AWARD This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0101104 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31521064 O and O a O project O of O the O China B-ORG National I-ORG Rice I-ORG Research I-ORG Institute I-ORG 2017RG001-2 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG #31571273/31771277/31371256 O the O Foreign B-ORG Distinguished I-ORG Scientist I-ORG Program I-ORG from I-ORG the I-ORG National I-ORG Department I-ORG of I-ORG Education I-ORG #MS2014SXSF038 O the O National B-ORG Department I-ORG of I-ORG Education I-ORG Central I-ORG Universities I-ORG Research I-ORG Fund I-ORG #GK20130100/201701005/GERP-17-45 O US B-ORG Maryland I-ORG Stem I-ORG Cell I-ORG Research I-ORG Fund I-ORG 2009MSCRFE008300 O and O the B-ORG Outstanding I-ORG Doctoral I-ORG Thesis I-ORG fund I-ORG #X2014YB02/X2015YB05 O This O work O was O financed O by O NSFC-Shandong B-ORG Joint I-ORG Fund I-ORG Key I-ORG Projects I-ORG U1806206 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31570063 O and I-AWARD 31870020 O Key B-ORG Deployment I-ORG Project I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG KFZD-SW-112 O the O Shandong B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2017GSF17129 O and O the O Shandong B-ORG Key I-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG Program I-ORG 2017CXGC0303 O This O study O was O funded O by O Cancer B-ORG Research I-ORG UK I-ORG C53258/A19682 O and O the O Medical B-ORG Research I-ORG Council O Chief B-ORG Scientist I-ORG Office I-ORG Social O O Public O Health O Sciences O Unit O University O of O Glasgow O under O the O Measuring O and O Analysing O Socioeconomic O Inequalities O in O Health O programme O MC_UU_12017/13 O O SPHSU13 B-AWARD Cancer O Research O UK O approved O the O final O study O design/proposal O There O was O no O involvement O of O the O funding O bodies O in O data O collection O analysis O and O interpretation O and O in O writing O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31802211 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG China I-ORG 2018YFE0101600 O I-AWARD 2017YFD0500201 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2662018QD003 O and O the O Postdoctoral B-ORG Research I-ORG Foundation I-ORG of I-ORG China I-ORG 2019T120671 O I-AWARD 2018M630873 O Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG JunranZ O Grant O No. O 2015HH0036 B-AWARD Chengdu B-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG JunranZ O Grant O No. O 2015HM0100561SF B-AWARD Sichuan B-ORG University-Luzhou I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG JunranZ O Grant O No. O 2017CDLZ-G2 B-AWARD The O financial O support O from O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFB1104700 O 2018YFB1107202 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 91750205 I-AWARD 61774155 I-AWARD 61705227 O Scientific B-ORG Research I-ORG Project I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG QYZDB-SSW-SYS038 O Jilin O Provincial O Science O O Technology O Development O Project O 20180414019GH O and O The O Key O Program O of O the O International O Partnership O Program O of O CAS O 181722KYSB20160015 O is O appreciated O R.A.G O thanks O the O financial O support O from O Chinese O Academy O of O Sciences O President’s O International O Fellowship O Initiative O Grant O No. O 2018VSA0001 O Theoretical O part O of O the O presented O work O was O supported O by O the O MEPhI O Academic O Excellence O Project O Contract O No. O 02.a03.21.0005 B-AWARD and O grants O of O the O German O Science O Foundation O DFG B-AWARD IV I-AWARD 122/4-1 I-AWARD and I-AWARD GA I-AWARD 465/15-2 O The O MD O simulations O were O performed O on O Lichtenberg O Super O Computer O Facility O TU-Darmstadt O Germany O This O study O was O supported O by O grants O from O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 81472272 B-AWARD and O 81602114 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grant O Nos O BK20161286 B-AWARD BE2019692 O Postdoctoral O Science O Foundation O of O China O Grant O No. O 2017M620221 O 2019M661909 O the O Social B-ORG Development I-ORG Foundation I-ORG of I-ORG Nantong I-ORG City I-ORG Grant O nos O MS22018006 O MS12019018 O MS12019020 O JC2019032 O MSZ19177 O and O MS12017002-6 B-AWARD Teaching O Research O Project O of O Affiliated O Hospital O of O Nantong O University O Tfj O 18006 O and O Jiangsu O Government O Scholarship O for O Overseas O Studies O JS-2018-122 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31230012 B-AWARD and I-AWARD 31700357 O the O State B-ORG Basic I-ORG Research I-ORG Program I-ORG 2016YFC0500602 O the O Program B-ORG for I-ORG Introducing I-ORG Talents I-ORG to I-ORG Universities I-ORG B16011 O and O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2016M590246 O and I-AWARD 2016M591470 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 52175513 B-AWARD Shanghai B-ORG Natural I-ORG Science I-ORG Foundation I-ORG project I-ORG of I-ORG “Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Plan” O grant O number O 20ZR1451000 B-AWARD and O Scientific B-ORG Research I-ORG Projects I-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Administration I-ORG for I-ORG Market I-ORG Supervision O grant O number O 2022-33 B-AWARD This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2022YFB3505502 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 52201230 O the O Beijing B-ORG NOVA I-ORG Program I-ORG Z211100002121092 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG E2021103006 O the O Key B-ORG R&D I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG 2022CXGC020307 O and O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2022M71204 O For O financial O support O of O this O research O the O authors O are O thankful O for O the O projects O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21788102 O 22271093 B-AWARD 21772040 B-AWARD and O 21971064 B-AWARD the O Shanghai B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG Grant O No. O 2018SHZDZX03 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 222201717003 O and O 50321101918001 B-AWARD and O the O Program B-ORG of I-ORG Introducing I-ORG Talents I-ORG of I-ORG Discipline I-ORG to I-ORG Universities I-ORG B16017 O This O research O was O supported O by O the O NSFC-Shandong B-ORG Joint I-ORG Fund I-ORG for I-ORG Marine I-ORG Science I-ORG Research I-ORG Centers I-ORG No. O U1406403 B-AWARD the O National B-ORG Marine I-ORG Public I-ORG Welfare I-ORG Research I-ORG Project I-ORG 201305043 O the O National B-ORG Science I-ORG I-ORG Technology I-ORG Basic I-ORG Work I-ORG Program I-ORG 2015FY110600 O and O the O Key O Projects O in O the O National B-ORG Science I-ORG I-ORG Technology I-ORG Pillar I-ORG Program I-ORG during I-ORG the I-ORG 12th I-ORG Five-year I-ORG Plan I-ORG Period I-ORG 2011BAD13B06 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Youth I-ORG Fund I-ORG 81903376 O to O Qiang O Gao O the O Training B-ORG Program I-ORG Foundations I-ORG for I-ORG Excellent I-ORG Youth I-ORG Medical I-ORG Talents I-ORG of I-ORG Shanghai I-ORG 2017YQ071 O to O Qiang O Gao O and O the O Major B-ORG Public I-ORG Health I-ORG project I-ORG of I-ORG Huangpu I-ORG District I-ORG HWZFX201805 O O HKW201624 B-AWARD to O Qiang O Gao O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O China B-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG for I-ORG Infectious I-ORG Diseases I-ORG Control I-ORG during I-ORG the I-ORG 13th I-ORG Five-Year I-ORG Plan I-ORG Period I-ORG 2017ZX10202202 O China-Singapore B-ORG International I-ORG S&T I-ORG Cooperation I-ORG Program I-ORG 2016YFE0116800 O and O Beijing B-ORG Medical I-ORG I-ORG Health I-ORG Technology I-ORG Promotion I-ORG Project I-ORG 2018-TG-19).2018-TG-19 O Beijing O Medical O O Health O Technology O Promotion O Project O 0.01 O million O RMB O to O Prof O Yang O RF. O The O fund O is O granted O from O the O local O government O of O Beijing O China O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 31670306 B-AWARD China B-ORG Agriculture I-ORG Research I-ORG System I-ORG grant O number O CARS-18 B-AWARD National O Natural O Science O Foundation O of O China O grant O number O 31700527 B-AWARD Fundamental B-ORG Research I-ORG Program I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Universities I-ORG grant O number O 17KJB220002 B-AWARD and O Research O Fund O of O Jiangsu O University O of O Science O and O Technology O grant O number O 1732931608 B-AWARD This O research O used O resources O of O the O Advanced O Photon O Source O B.L O a O U.S B-ORG Department I-ORG of I-ORG Energy I-ORG DOE O Office O of O Science O User O Facility O operated O for O the O DOE O Office O of O Science O by O Argonne O National O Laboratory O under O Contract O No. O DE-AC02-06CH11357 B-AWARD Q. O J. O was O supported O by O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG under O Grant O 1R01GM104530 B-AWARD awarded O to O Chris O Jacobsen O at O Argonne O National O Laboratory O and O Northwestern O University O L. O K. O was O supported O by O National B-ORG Institutes I-ORG of I-ORG Health I-ORG Grant O 1R21NS082786 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O financially O supported O by O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 I-ORG Program I-ORG 2014CB138600 O Science B-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG of I-ORG Sichuan I-ORG Province I-ORG of I-ORG China I-ORG 2014NZ0003 O Major B-ORG Scientific I-ORG and I-ORG Technological I-ORG Achievement I-ORG Transformation I-ORG Project I-ORG of I-ORG Sichuan I-ORG Province I-ORG of I-ORG China I-ORG 2012NC0007 O 2013NC0045 O the B-ORG Demonstration I-ORG of I-ORG Major I-ORG Scientific I-ORG and I-ORG Technological I-ORG Achievement I-ORG Transformation I-ORG Project I-ORG of I-ORG Sichuan I-ORG Province I-ORG of I-ORG China I-ORG 2015CC0011 O Natural B-ORG Science I-ORG Foundation I-ORG for I-ORG Young I-ORG Scientists I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2014JQ0007 O and O Sichuan B-ORG Province I-ORG Research I-ORG Foundation I-ORG for I-ORG Basic I-ORG Research I-ORG 2013JY0082 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Fund I-ORG of I-ORG China I-ORG 31872499 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0500505 O and O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG 2018ZX10101002 O The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Research O reported O in O this O publication O was O supported O in O part O by O the O OneFlorida O Clinical O Research O Consortium O funded O by O the O Patient-Centered O Outcomes O Research O Institute O award O number O CDRN-1501-26692 O in O part O by O the O OneFlorida O Cancer O Control O Alliance O funded O by O the O Florida B-ORG Department I-ORG of I-ORG Health’s O James O and O Esther O King O Biomedical O Research O Program O award O number O 4KB16 B-AWARD and O in O part O by O the O University O of O Florida O Clinical O and O Translational O Science O Institute O which O is O supported O in O part O by O the O NIH O National B-ORG Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences I-ORG under O award O number O UL1TR001427 B-AWARD Dr. O Salloum O is O a O fellow O of O the O Mentored O Training O for O Dissemination O and O Implementation O Research O in O Cancer O MT-DIRC O Program O National B-ORG Cancer I-ORG Institute I-ORG award O number O R25CA171994 B-AWARD The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O Patient-Centered O Outcomes O Research O Institute O PCORI O its O Board O of O Governors O or O Methodology O the O OneFlorida O Clinical O Research O Consortium O the O University O of O Florida’s O Clinical O and O Translational O Science O Institute O the O Florida O Department O of O Health O or O the O National O Institutes O of O Health O The O authors O appreciate O the O financial O support O for O this O work O from O The B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFB0701405 O Aeronautical B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 2016ZE57010 O New O Young O Teachers O Initiation O Program O Fund O 18X100040027 O and O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 19Z102060057 O This O research O was O funded O by O grant O PS09/01035 B-AWARD from O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III O N.A O and O M.G-C O held O a O predoctoral O fellowship O from O ISCIII B-ORG FI11/0008 O and O Ministerio B-ORG de I-ORG Educación I-ORG Cultura I-ORG y I-ORG Deporte I-ORG FPU15/03005 O respectively O CIBER O of O Diabetes O and O Associated O Metabolic O Diseases O CIBERDEM O the O current O study O was O led O by O group O CB15/00071 O and O CIBER O Epidemiología O y O Salud O Pública O CIBERESP O are O an O initiative O from O the O Instituto O de O Salud O Carlos O III O Plan O Nacional O de O I O O D O O I O and O Fondo O Europeo O de O Desarrollo O Regional O This O project O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81772887 O the O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O 2014-37 B-AWARD Jiangsu B-ORG Provincial I-ORG Medical I-ORG Innovation I-ORG Team I-ORG CXTDA2017036 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG of I-ORG China I-ORG BK20171488 O Postgraduate B-ORG Research I-ORG Practice I-ORG Innovation I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG KYLX16_1122 O and O Jiangsu B-ORG Provincial I-ORG Medical I-ORG Youth I-ORG Talent I-ORG QNRC2016854 O This O work O was O supported O in O part O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG P20 O GM109090 O SPiRE O Award O I21RX003294 B-AWARD from O the O United B-ORG States I-ORG US) I-ORG Department I-ORG of I-ORG Veterans I-ORG Affairs O and O by O Netherlands O Organization I-ORG for I-ORG Scientific I-ORG Research I-ORG NWO O 016.Vidi.178.014 O This O work O was O supported O in O part O by O the O funds O from O the O University O of O Nebraska O at O Omaha O Graduate O Research O and O Creative O Activity O Fund O FFT O This O research O was O funded O by O the O Bulgarian B-ORG Ministry I-ORG of I-ORG Education I-ORG and I-ORG Science I-ORG through O the O National O Scientific O Program O “Innovative O Low-Toxic O Biologically O Active O Means O for O Precision O Medicine” O BioActiveMed O Grant O No. O DO1-217/30.11.2018 B-AWARD the O Medical B-ORG University I-ORG of I-ORG Sofia O contract O № O 7-D/2015 B-AWARD from O “Young O Researcher O Contest O 2016” O and O The O National O Science O Program O “Healthy O Foods O for O a O Strong O Bio-economy O and O Quality O of O Life” O Ministry B-ORG of I-ORG Education I-ORG and I-ORG Science I-ORG Bulgaria O No. O DSD-3/19.02.2019 B-AWARD This O work O was O supported O by O the O Projects O of O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG [grant O number O 81671273 B-AWARD grant O number O 81171204 B-AWARD grant O number O 30772280 B-AWARD grant O number O 81400925 B-AWARD grant O number O 81471148 B-AWARD grant O number O 81771211 B-AWARD grant O number O 81703852 B-AWARD the O Project O of O Shanghai B-ORG Municipal I-ORG Education I-ORG Commission I-ORG of O China O grant O number O 14YZ046 B-AWARD the O Project O of O Shanghai B-ORG Municipal I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of O China O grant O number O 20134049 B-AWARD the O Project O of O Shanghai B-ORG Jiao I-ORG Tong I-ORG University I-ORG of O China O grant O number O YG2013MS22 B-AWARD the O Project O of O National B-ORG Eastern I-ORG Tech-transfer I-ORG Center I-ORG grant O number O 201713972877 B-AWARD the O Projects O of O Shanghai B-ORG Committee I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG grant O number O 17401901000 B-AWARD National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG grant O number O 2017YFC1310300 B-AWARD and O SHSMU-ION B-ORG Research I-ORG Center I-ORG for I-ORG Brain I-ORG Disorders I-ORG grant O number O 2015NKX007 B-AWARD This O research O was O funded O by O grants O from O the O Innovation B-ORG and I-ORG Capacity-Building I-ORG Project I-ORG of I-ORG BAAFS I-ORG KJCX20200204 O and O KYCX20210427 B-AWARD Beijing B-ORG Joint I-ORG Research I-ORG Program I-ORG for I-ORG Germplasm I-ORG Innovation I-ORG and I-ORG New I-ORG Variety I-ORG Breeding I-ORG G20220628003-01 O and O the O Outstanding B-ORG Scientists I-ORG Training I-ORG Program I-ORG of I-ORG Beijing I-ORG Academy I-ORG of I-ORG Agriculture I-ORG Forestry I-ORG Sciences I-ORG JKZX201906 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31830090 O the O Basic B-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG province I-ORG 2019B1515120059 O and O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG CAAS-ZDRW202006 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31722001 O and I-AWARD 31670089 O the O Key B-ORG Program I-ORG of I-ORG CAS I-ORG ZDRW-ZS-2016-3M O and I-AWARD ZDBS-SSW-DQC002-03 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2016M600564 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG province O JQ201707 O The O present O work O was O supported O financially O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG no. O 2016YFB0303101 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG nos O 51303085 B-AWARD 51503105 B-AWARD and O 51803094 B-AWARD Natural B-ORG Science I-ORG Research I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG 17KJB540002 O This O project O was O supported O by O grants O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG http://program.most.gov.cn O 2016YFD0100600 O to O YN O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG http://www.nsfc.gov.cn O 31571944 O to O YN O and O 31622008 O to O YW O the O Young B-ORG Elite I-ORG Scientist I-ORG Sponsorship I-ORG of I-ORG China I-ORG Association I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG http://www.cast.org.cn O 2015QNRC001 O to O YN O and O the O US O National O Science O Foundation O IOS#1120949 O to O GLW O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2019YFD1000300 O and O 2018YFD1000800 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31872158 O and O 31772358 B-AWARD and O Earmarked B-ORG Fund I-ORG for I-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG CAS-23 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O U20A2058 B-AWARD No. O 31830094 B-AWARD and O No. O 31401106 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Chongqing I-ORG No. O cstc2020jcyj-msxmX0450 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG in I-ORG China I-ORG No. O XDJK2019C009 B-AWARD Funds B-ORG of I-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG No. O CARS-18-ZJ0102 B-AWARD The O National B-ORG Natural I-ORG Science I-ORG Fund I-ORG of I-ORG China I-ORG Nos O 81572431 B-AWARD 81773281 B-AWARD Anhui B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG No. O 1604a0802094 B-AWARD University O Natural O Science O Research O Project O of O Anhui O Province O No. O KJ2018ZD011 B-AWARD Huainan B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG No. O 2017B41 B-AWARD Young O Medical O Talents O in O Jiangsu O Province O No. O QNRC2016421 B-AWARD Six O Talent O Peak O Project O in O Jiangsu O Province O No. O WSN-252 B-AWARD and O “533” O Leading O Personnel O Project O No. O HAA201740 B-AWARD funded O this O research O This O work O was O supported O by O the O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81801515 O 81801494 B-AWARD Suzhou B-ORG talent I-ORG training I-ORG program I-ORG GSWS2019005 O Suzhou B-ORG introduce I-ORG expert I-ORG team I-ORG of I-ORG clinical I-ORG medicine I-ORG SZYJTD201708 O and O Suzhou O Science O and O Technology O for O People’s O Livelihood O SYS2019097 O This O work O was O supported O financially O by O the O Shanghai B-ORG Agriculture I-ORG Applied I-ORG Technology I-ORG Development I-ORG Program I-ORG China I-ORG Grant O No. O X2021-02-08-00-12-F00797 B-AWARD earmarked B-ORG funding I-ORG for I-ORG the I-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG China I-ORG Grant O No. O CARS-20 B-AWARD the O Leading B-ORG Talents I-ORG Fund I-ORG in I-ORG Minhang I-ORG District I-ORG of I-ORG Shanghai I-ORG China I-ORG Grant O No. O 201844 B-AWARD and O the O SAAS B-ORG Program I-ORG for I-ORG Excellent I-ORG Research I-ORG Team I-ORG Grant O No. O G2022003 B-AWARD This O work O is O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG 2019JJ50932 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81803035 O 81703036 B-AWARD 81572946 B-AWARD Hospital B-ORG Management I-ORG Research I-ORG Foundation I-ORG of I-ORG Xiangya I-ORG Hospital I-ORG No. O 2016GL21 B-AWARD and O Clinical B-ORG Big I-ORG Data I-ORG System I-ORG Construction I-ORG Project I-ORG of I-ORG Central I-ORG South I-ORG University I-ORG No. O 46 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O Medical B-ORG Research I-ORG Foundation I-ORG MRF-091-0003-RG-CONFO O to O F.C O Medical B-ORG Research I-ORG Council I-ORG MRC-G0900453 O to O D.E.D O and O the O British B-ORG Lung I-ORG Foundation I-ORG IPFPG12-2 O to O D.E.D O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O project O was O supported O by O the O Program B-ORG for I-ORG the I-ORG 12th I-ORG Five-year I-ORG Plan I-ORG of I-ORG China I-ORG AWS13J004 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC1300600 O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 7162143 O and O Beijing B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG China I-ORG Z141100000214003 O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 51371042 B-AWARD Liaoning B-ORG Province I-ORG Natural I-ORG Science I-ORG Fund I-ORG Project I-ORG grant O no. O 20180550420 B-AWARD and O Co-professional B-ORG Graduates I-ORG Program I-ORG of I-ORG the I-ORG Liaoning I-ORG Provincial I-ORG Universities I-ORG grant O no. O 115-3110617005 B-AWARD This O work O was O supported O by O the O Federal O Ministry O of O Education O and O Research O Germany O FKZ O 0312138A O and O FKZ O 316159 O the O State O Mecklenburg-Western O Pomerania O with O EU B-ORG Structural I-ORG Funds O ESF/IVWM-B34-0030/10 O and O ESF/IVBM-B35-0010/12 O and O the O DFG B-ORG DA1296/6-1 O the O German B-ORG Heart I-ORG Foundation I-ORG F/01/12 O and O the O German O Heart O Research O Foundation O F/34/15 O In O addition O R.D O is O supported O by O the O EU O Structural O Fund O ESF/14-BM-A55-0024/18 O the O FORUN O Program O of O Rostock O University O Medical O Centre O 889001 O and O 889003 O the O Josef O and O Käthe O Klinz O Foundation O T319/29737/2017 O the O DAMP O Foundation O and O the O BMBF B-ORG VIP O 00240 O The O small O animal O PET/CT O was O funded O by O the O Deutsche O Forschungsgemeinschaft O INST O 2268/6-1 I-AWARD FUGG O The O small O animal O MRI O system O was O funded O by O the O European O Regional O Development O Fund O EFRE O UHROM O 16 O C.I.L O was O supported O by O the O Clinician O Scientist O Program O of O the O Rostock O University O Medical O Center O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31901993 O 31970312 B-AWARD 32272682 B-AWARD 32170315 B-AWARD 31970200 B-AWARD the O Natural B-ORG Science I-ORG Foundations I-ORG of I-ORG Anhui I-ORG Province I-ORG 1908085MC72 O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG of I-ORG Anhui I-ORG Province I-ORG 202003a06020011 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG JZ2021HGPA0063 O This O research O was O funded O by O Far B-ORG Eastern I-ORG Memorial I-ORG Hospital I-ORG FEMH-2023-C-037 O the B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Taiwan I-ORG MOST O 110-2314-B-418-006 O and O the O NYMU-FEMH B-ORG Joint I-ORG Research I-ORG Program I-ORG 111DN32 B-AWARD This O study O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81972324 B-AWARD the O China B-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG Grant O No. O 2016-I2M-3-019 B-AWARD and O the O non-profit B-ORG Central I-ORG Research I-ORG Institute I-ORG Fund I-ORG of I-ORG Chinese I-ORG of I-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG grant O no.2018PT32014 O And O the O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O in O publication O or O preparation O of O the O manuscript O The O research O report O here O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31801295 O 31601257 B-AWARD the O Shandong B-ORG Province I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Doctoral O Fund I-AWARD ZR2017BC106 O the O Project B-ORG funded I-ORG by I-ORG China I-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M632701 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0300400 O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 O Program O NO. O 2015CB150404 B-AWARD and O the O Opening B-ORG fund I-ORG of I-ORG the I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Crop I-ORG Biology I-ORG 2016KF04 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O is O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O No. O 11674110 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O China O under O Grant O No. O 2016A030308010 B-AWARD and O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG China O under O Grant O No. O 2015B090927006 B-AWARD This O research O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31422057 B-AWARD the O National B-ORG High-Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 863 O program O 2011AA100401 B-AWARD and O the O Special B-ORG Scientific I-ORG Research I-ORG Funds I-ORG for I-ORG Central I-ORG Non-profit I-ORG Institutes I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Fishery I-ORG Sciences I-ORG 2014A03YQ01 O and O 2016GH02 O The O authors O would O like O to O extend O their O sincere O appreciation O to O the O Deanship B-ORG of I-ORG Scientific I-ORG Research I-ORG at I-ORG King I-ORG Saud I-ORG University I-ORG for O funding O this O research O No. O RG B-AWARD 1435-012 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O partially O supported O by O GSJ’s O Hatch B-ORG project I-ORG IND011280 O by O the O IOS-NSF B-ORG grant I-ORG 0547132 B-AWARD https://www.nsf.gov/awardsearch/showAward?AWD_ID=0547132 O to O GSJ O and O by O the O National B-ORG Science I-ORG Foundation I-ORG Plant I-ORG Genome I-ORG Research I-ORG Program I-ORG grant O 1444503 B-AWARD https://www.nsf.gov/awardsearch/showAward?AWD_ID=1444503 O to O BPD O and O GSJ O The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O Independent B-ORG Research I-ORG Fund I-ORG Denmark O grant O number O 8020-00446A B-AWARD Innovation B-ORG Fund I-ORG Denmark O grant O no O 7038-00212B B-AWARD and O 9090-00024B B-AWARD Novo B-ORG Nordisk I-ORG Foundation O grant O number O NNF18SA0034956 B-AWARD Holms O Mindelegat O grant O no O 20006-1982 O HARBOEFONDEN O Svend O Andersen O Fonden O and O Toyota O Fund O Denmark O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81903672 O Peking B-ORG University I-ORG People’s I-ORG Hospital I-ORG Research I-ORG and I-ORG Development I-ORG Funds I-ORG RDY2018-14 O and O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2017ZX10103004006 O The O funding O bodies O had O no O role O in O the O design O of O the O study O in O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81570122 B-AWARD 81770205 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG No. O 2016YFC0902800 B-AWARD and O the O Shanghai B-ORG Municipal I-ORG Education I-ORG Commission-Gaofeng I-ORG Clinical I-ORG Medicine I-ORG Grant I-ORG Support I-ORG 20161303 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Israel B-ORG Science I-ORG Foundation I-ORG Grant O 500/15 B-AWARD Broad-Israel B-ORG Science I-ORG Foundation I-ORG Grant O 1644/15 B-AWARD and O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG Grants B-AWARD R24 I-AWARD AI072073 I-AWARD to O TS O and O YL. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Research O Fund O of O Hunan B-ORG Provincial I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG No. O B2016107 B-AWARD Young B-ORG Scientists I-ORG Fund I-ORG of I-ORG Xiangya I-ORG Hospital I-ORG 2014Q05 O and O Xiangya B-ORG Sinobio I-ORG way I-ORG Health I-ORG Research I-ORG Fund I-ORG No. O xywm2015I11 B-AWARD PDO O is O funded O by O the O Heart B-ORG and I-ORG Stroke I-ORG Foundation I-ORG of I-ORG Canada I-ORG http://www.heartandstroke.ca O grant O number O G-17-0018613 B-AWARD the O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG http://www.cihr-irsc.gc.ca/e/193.html O grant O number O PJT-149046 B-AWARD the O Natural B-ORG Sciences I-ORG and I-ORG Engineering I-ORG Research I-ORG Council I-ORG of I-ORG Canada I-ORG http://www.nserc-crsng.gc.ca/index_eng.asp O grant O number O 500865 B-AWARD and O Operational O Funds O from O The O Hospital O for O Sick O Children O https://www.sickkids.ca O and O University B-ORG of I-ORG Toronto I-ORG Fellowship B-AWARD Award I-AWARD to O AA. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O International O Collaborative O Research O Grants O Scheme O with O joint O grants O from O the O Wellcome B-ORG Trust I-ORG UK O GR071587MA O and O the O Australian O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG NHMRC O grant O No.268055 O It O was O also O supported O by O a O global O health O grant O from O the O NHMRC O 585426 O SJ O is O supported O by O a O Career B-AWARD Development I-AWARD Fellowship I-AWARD from O the O NHMRC O KP O has O an O Australian B-AWARD Postgraduate I-AWARD Award I-AWARD from O the O Australian B-ORG National I-ORG University I-ORG The O study O was O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No.81760567 O 81802474 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG China I-ORG ZR2018MC012 O ZR2014HL020 B-AWARD ZR2014HL021 B-AWARD and O the O Project B-ORG Funding I-ORG for I-ORG the I-ORG Development I-ORG of I-ORG Medical I-ORG and I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG in I-ORG Shandong I-ORG Province I-ORG 2014WS0464 O and O the O Neurologic O Disorders O and O Regenerative O Repair O Lab O “13th O five-year O plan” O Key O Lab O of O Shandong O Higher O Education O This O work O is O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81172578 B-AWARD the O Project B-ORG of I-ORG Medical I-ORG innovation I-ORG of I-ORG Fujian I-ORG Province I-ORG Grant O No. O 2015-CXB-35 B-AWARD and O the O Project B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Xiamen I-ORG City I-ORG Grant O No. O 3502Z20134007 B-AWARD The O funders O had O no O role O in O the O design O of O the O study O and O collection O analysis O interpretation O of O data O and O preparation O of O the O manuscript O P.G O gratefully O acknowledges O support O from O the O Swedish B-ORG Foundation I-ORG for I-ORG Strategic I-ORG Research I-ORG grant O no. O AM13-0046 B-AWARD and O Vetenskapsrådet B-ORG grant O no. O 2014-6095 B-AWARD P.M.A O gratefully O acknowledges O support O from O Deutsche B-ORG Akademie I-ORG der I-ORG Naturforscher I-ORG Leopoldina O grant O no. O LPDS B-AWARD 2012-12 I-AWARD for O part O of O this O work O at O Harvard O University O and O generous O support O from O the O Moffitt O Cancer O Center O and O Research O Institute O To O ST: O Cancerfonden B-ORG 140780 B-AWARD www.cancerfonden.se O Vetenskapsrådet B-ORG 621-2013-5258 B-AWARD www.vr.se O Knut B-ORG och I-ORG Alice I-ORG Wallenbergs I-ORG Stiftelse O KAW2011.0165 B-AWARD http://www.wallenberg.com/kaw O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 32272833 B-AWARD Shandong B-ORG Provincial I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2021LZGC001 O and O Zhejiang B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Program I-ORG on I-ORG Agricultural I-ORG New I-ORG Variety I-ORG Breeding I-ORG Grant O number O 2021C02068-1 B-AWARD This O work O was O supported O by O CAS B-ORG Interdisciplinary I-ORG Innovation I-ORG Team I-ORG Project I-ORG No. O JCTD-2020-14 B-AWARD the B-ORG Strategic I-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Grant O No. O XDA28040102 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O U21A2037 B-AWARD and O Youth B-ORG Innovation I-ORG Promotion I-ORG Association I-ORG CAS I-ORG No. O Y2021068 B-AWARD We O appreciate O the O financial O supports O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG no. O 2018YFB0505200 B-AWARD and O the B-ORG Joint I-ORG Funds I-ORG for I-ORG Civil I-ORG Aviation I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O U1833201 B-AWARD to O YY. O In O addition O this O research O was O supported O in O part O by O the O Basic B-ORG Research I-ORG Program I-ORG of I-ORG Shenzhen I-ORG no. O JCYJ20170306171431656 B-AWARD to O YY. O This O research O was O supported O by O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Pillar I-ORG Program I-ORG of I-ORG China I-ORG 2012BAD14B16-04 O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2012B020310005 O and I-AWARD 2015B090903077 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U1701236 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51805137 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Province I-ORG No. O 1808085QE129 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of O China O JZ2019HGTB0076 O the O open O project O of O Anhui O Province O Key O Laboratory O of O Non-Destructive O Evaluation O Hefei O ZC O Optoelectronic O Technologies O Ltd O No. O CGHBMWSJC04 O and O the O open O project O of O Key O Laboratory O of O Micro O Opto-electro O Mechanical O System O Technology O Tianjin O University O Ministry O of O Education O No. O MOMST2015-6 O This O work O was O support O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81700364 O Jiangsu B-ORG Natural I-ORG Science I-ORG Foundation I-ORG BK20170179 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG JUSRP11754 O and O Postgraduate O Research O O Practice O Innovation O Program O of O Jiangsu O Provence O code O number O SJCX18_0642 O This O work O was O supported O by O the O “National O Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0200500)” O “Open O Project I-ORG Program I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG for I-ORG Biology I-ORG of I-ORG Plant I-ORG Disease I-ORG and I-ORG Insect I-ORG Pests I-ORG SKLOF201707)” O and O the O “Open O Project I-ORG Program I-ORG of I-ORG Engineering I-ORG Research I-ORG Center I-ORG of I-ORG Ecology I-ORG and I-ORG Agricultural I-ORG Use I-ORG of I-ORG Wetland I-ORG Ministry I-ORG of I-ORG Education I-ORG KF201802)” O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG China I-ORG 2016YFA0102500 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81801066 O and O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M640706 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG 81773393 O 81502787 B-AWARD Hunan B-ORG Provincial I-ORG Innovation I-ORG Foundation I-ORG for I-ORG Postgraduate I-ORG CX20190238 O Central B-ORG South I-ORG University I-ORG Innovation I-ORG Driven I-ORG Project I-ORG 20170027010004 O and O Ministry O of O Science O and O Technology O of O China O 2016YFC0900802 O 2015FY111100 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 31471551 B-AWARD the O International B-ORG Science I-ORG and I-ORG Technology I-ORG Cooperation I-ORG Program I-ORG of I-ORG China I-ORG grant O no. O 2013DFA32020 B-AWARD the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O no. O 2012AA101204-2 B-AWARD and O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG grant O no. O 2010CB126600 B-AWARD This O study O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Excellent I-ORG Young I-ORG Scientists I-ORG Fund I-ORG 82022064 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG International/Regional O Research O Collaboration O Project O 72061137001 O and O Program O from O Wuxi B-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG Y20222006 O The O funding O parties O did O not O have O any O role O in O the O design O of O the O study O or O in O the O explanation O of O the O data O This O research O was O financially O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0101802 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31600216 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province O China O C2017301066 O and O the O HAAFS B-ORG Agriculture I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG 2019-4-8-1 O The O funding O bodies O played O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O study O was O supported O by O National B-ORG Science I-ORG Centre I-ORG of I-ORG Poland I-ORG 2011/01/B/NZ4/03719 O TEAM O program O of O Foundation B-ORG for I-ORG Polish I-ORG Science I-ORG TEAM/2011-8/7 O and O Italian B-ORG Ministry I-ORG of I-ORG Education I-ORG University I-ORG and I-ORG Research I-ORG by I-ORG the I-ORG Fund I-ORG for I-ORG Investments I-ORG on I-ORG Basic I-ORG Research I-ORG RBAP06LAHL O The O research O was O sponsored O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31370458 O 31600432 I-AWARD 41571042 O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFA0604801 O 2016YFC0502005 O Youth B-ORG Innovation I-ORG Research I-ORG Team I-ORG Project I-ORG LENOM2016Q0002 O the O Bingwei O Outstanding O Young O Talents O Program O of O Institute O of O Geographic O Sciences O and O Natural O Resources O Research O Chinese O Academy O of O Sciences O 2018RC202 O and O the O Tibet O Science O and O Technology O Major O Projects O of O the O Pratacultural O Industry O XZ201901NA03 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Key B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Inner I-ORG Mongolia I-ORG Autonomous I-ORG Region I-ORG 2021ZD0012 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2021YFD1600704 O and O the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-39-12 O This O research O was O supported O by O grant O 2016YFD0101801 O from O The B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG and I-ORG Technology I-ORG Department O grant O 31560386 O from O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG and O grant O 201710410018 O from O National B-ORG Undergraduate I-ORG Training I-ORG Program I-ORG for I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31772099 O 31401573 I-AWARD and I-AWARD 21505071 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017T100446 O 2016M592050 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Province I-ORG 1908085MC98 O the O Key O Research O and O Development O Program O of O Anhui O Province O 201904a06020030 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG JZ2018HGTB0245 O This O study O was O funded O by O National O Natural O Science O Foundation O of O China O NSFC O Grant O NO. O 31460447 B-AWARD General B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Nanchang I-ORG City I-ORG 3000035402 O “555 O Talent O Project” O of O Jiangxi O Province O the B-ORG Science I-ORG Funds I-ORG of I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Province I-ORG 20114BAB205039 O 20171BAB214004 O Doctor B-ORG and I-ORG master I-ORG specific I-ORG projects I-ORG of I-ORG Honghe I-ORG University I-ORG XJ17B09 O the B-ORG project I-ORG of I-ORG young I-ORG and I-ORG middle-aged I-ORG talent I-ORG of I-ORG Yunnan I-ORG province I-ORG Grant O No. O 2016PY068 B-AWARD and O Science B-ORG and I-ORG Technology I-ORG Research I-ORG Project I-ORG of I-ORG Jiangxi I-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG GJJ160765 O GJJ160795 I-AWARD and I-AWARD GJJ160794 O The O funders O contributed O to O the O study O design O This O work O was O financially O supported O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG of I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG the I-ORG People’s I-ORG Republic I-ORG of I-ORG China I-ORG 2022YFA1104704 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31971318 O and O 22027810 B-AWARD Key-Area B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2020B0101020001 O The O study O was O funded O by O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81402767 O the O Medical B-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Fund I-ORG of I-ORG Guangdong I-ORG Province I-ORG WSTJJ20140116510124198504200421 O China B-ORG Medical I-ORG Board I-ORG 13-175 O and O Sun O Yat-sen O University O 15ykpy08 O The O sponsors O are O not O involved O in O study O design O in O the O collection O analysis O and O interpretation O of O data O in O the O writing O of O the O report O and O in O the O decision O to O submit O the O paper O for O publication O This O work O was O supported O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG as O part O of O the O International O Centres O of O Excellence O in O Malaria O Research O ICMER O Program O for O Resistance O Immunology O Surveillance O and O Modelling O of O Malaria O in O Uganda O grant O number O U19AI089674 B-AWARD AJT O is O supported O by O a O Wellcome B-ORG Trust I-ORG Sustaining O Health O Grant O grant O number O 106866/Z/15/Z B-AWARD and O Bill B-ORG and I-ORG Melinda I-ORG Gates I-ORG Foundation I-ORG grant O numbers O OPP1106427 B-AWARD 1032350 I-AWARD OPP1134076 O The O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81273091 O 81530086 O Shanghai B-ORG Municipal I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG GWIV-26 O 15GWZK0401 B-AWARD Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG 14XD1403300 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O carried O out O under O the O Project B-ORG InPacTus—Innovative I-ORG products I-ORG and I-ORG technologies I-ORG from I-ORG eucalyptus O Project B-AWARD N.º I-AWARD 21874 I-AWARD POCI-01-0247-FEDER-021874 O funded O by O Portugal O 2020 O through O the O European B-ORG Regional I-ORG Development I-ORG Fund I-ORG ERDF O in O the O frame O of O COMPETE B-AWARD 2020 I-AWARD nº I-AWARD 246/AXIS I-AWARD II/2017 O and O the O projects O CICECO–Aveiro B-ORG Institute I-ORG of I-ORG Materials I-ORG UIDB/50011/2020 O UIDP/50011/2020 B-AWARD and O LA/P/0006/2020 B-AWARD LAQV-REQUIMTE B-ORG UIDB/50006/2020 O and O UIDP/50006/2020 B-AWARD and O CIBB B-ORG UIDB/04539/2020 O and O UIDP/04539/2020 B-AWARD financed O by O national O funds O through O the O FCT/MEC B-ORG PIDDAC O FCT O is O also O acknowledged O for O the O research O contract O under O the O Scientific B-ORG Employment I-ORG Stimulus I-ORG to O S. O Santos O 2021.03348.CEECIND O National B-ORG Human I-ORG Genome I-ORG Research I-ORG Institute I-ORG 5U41HG002371 O to O G.P.B O H.C O J.N.G O M.H O D.H O A.S.H O W.J.K O R.M.K O B.T.L O C.M.L O L.R.N O C.C.P O B.J.R O K.R.R O D.S O M.L.S O A.S.Z O 2U41HG007234 O to O M.D O D.H O National O Institute O of O Mental O Health O National B-ORG Institutes I-ORG of I-ORG Health I-ORG 5U01MH114825 O to O W.J.K O California B-ORG Institute I-ORG for I-ORG Regenerative I-ORG Medicine I-ORG GC1R-06673-C O to O J.C O M.H O W.J.K O B.T.L O M.L.S O A.S.Z O Howard B-ORG Hughes I-ORG Medical I-ORG Institute I-ORG 090100 O to O D.H O Regeneron B-ORG CBJCHBCAABAA-nBGXMxFrE0WG7VvHOtm8RAzv674WMNt O to O H.C O J.N.G O R.M.K O St. B-ORG Baldricks I-ORG Foundation I-ORG 427053to O D.H O Silicon B-ORG Valley I-ORG Community I-ORG Foundation I-ORG 2018-182809 O to O J.C O M.H O W.J.K O M.L.S O 2017-171519 B-AWARD to O G.P.B O J.C O M.D O M.H O W.J.K O B.T.L O M.L.S O A.S.Z O 2018-194093 B-AWARD to O M.D O Funding O for O open O access O charge O National O Human O Genome O Research O Institute O 5U41HG002371 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 30971806 B-AWARD 31201266 I-AWARD and I-AWARD 31401430 O the O State B-ORG Ministry I-ORG of I-ORG Agriculture I-ORG “948” I-ORG Project I-ORG 2014-Z39 O Shanxi B-ORG Province I-ORG Key I-ORG Projects I-ORG of I-ORG Coal-based I-ORG Science I-ORG and I-ORG Technology I-ORG FT-2014-01 O Research O Project O Supported O by O Shanxi B-ORG Scholarship I-ORG Council I-ORG of I-ORG China I-ORG 2015-064 O and O the O Key B-ORG Project I-ORG of I-ORG the I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shanxi I-ORG Province I-ORG China I-ORG Grant O No. O 201603D312005 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O is O supported O by O the O Henan B-ORG science I-ORG and I-ORG technology I-ORG research I-ORG plan I-ORG project I-ORG 222102220079 O the O Training B-ORG plan I-ORG for I-ORG young I-ORG backbone I-ORG teachers I-ORG in I-ORG universities I-ORG of I-ORG Henan I-ORG Province I-ORG 2019GGJS082 O and O the O Basic B-ORG research I-ORG plan I-ORG project I-ORG of I-ORG key I-ORG scientific I-ORG research I-ORG projects I-ORG of I-ORG universities I-ORG in I-ORG Henan I-ORG Province I-ORG 17A460003 O We O acknowledge O the O financial O supports O of O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81301267 B-AWARD the O Suzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Program I-ORG SZS201618 O and O the B-ORG research I-ORG foundation I-ORG of I-ORG the I-ORG Second I-ORG Affiliated I-ORG Hospital I-ORG of I-ORG Soochow I-ORG University I-ORG SDFEYQN201302 O S4 O File O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O authors O wish O to O acknowledge O the O financial O support O provided O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Project O No. B-AWARD 2018YFA0902100 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 21576197 O and O Tianjin B-ORG Research I-ORG Program I-ORG of I-ORG Application I-ORG Foundation I-ORG and I-ORG Advanced I-ORG Technology I-ORG No. O 18JCYBJC23500 O The O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 81601641 B-AWARD and I-AWARD 81871526 O the O Guangdong B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O Nos O 2014A030310504 B-AWARD and I-AWARD 2020A1515010370 O the O Scientific O Research O Foundation O for O the O Returned O Overseas O Chinese O Scholars O the O National B-ORG Education I-ORG Ministry I-ORG Grant O No. O 2015-311 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O Modern B-ORG Agroindustrial I-ORG Technology I-ORG Research I-ORG Systems I-ORG in I-ORG China I-ORG CARS-37 O National B-ORG Public I-ORG Benefit I-ORG Research I-ORG Agriculture I-ORG Foundation I-ORG 201303085 O and O Jilin B-ORG Agricultural I-ORG Innovation I-ORG Project I-ORG 52110302 O SL O received O the O fundings O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Shanxi B-ORG Province I-ORG Graduate I-ORG Education I-ORG Innovation I-ORG Project I-ORG 2021Y352 O Fundamental B-ORG Research I-ORG Program I-ORG of I-ORG Shanxi I-ORG Province I-ORG 202103021224335 O Yangquan B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG 2022JH067 O and O Scientific B-ORG and I-ORG Technologial I-ORG Innovation I-ORG Programs I-ORG of I-ORG Higher I-ORG Education I-ORG Institutions I-ORG in I-ORG Shanxi I-ORG 2022L595 O This O work O was O supported O by O the O Netherlands B-ORG Organisation I-ORG for I-ORG Scientific I-ORG Research I-ORG through O the O Soehngen O Institute O of O Anaerobic O Microbiology O SIAM O Gravitation O Grant O grant O number O 024.002.002 B-AWARD to O JF, O MSMJ O and O CUW O the O Netherlands B-ORG Earth I-ORG System I-ORG Science I-ORG Centre I-ORG Gravitation O Grant O grant O number O 024.002.001 B-AWARD to O MHitZ O and O MSMJ O and O the O European B-ORG Research I-ORG Council I-ORG Advanced O Grant O Ecology O of O Anaerobic O Methane O Oxidizing O Microbes O grant O number O 339880 B-AWARD to O MSMJ O This O work O was O supported O by O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O Grant/Award O Number O 81560552 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangxi I-ORG China O Grant/Award O Number O 2018GXNSFAA138120 B-AWARD Key B-ORG Research I-ORG Projects I-ORG of I-ORG Guangxi O China O Grant/Award O Number O 2018AB58018 B-AWARD This O work O is O jointly O funded O by O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U1811462 O the O National B-ORG Key I-ORG R&D I-ORG project I-ORG by I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2018YFB1003203 O and O the O open O fund O from O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG High I-ORG Performance I-ORG Computing I-ORG No. O 201901-11 B-AWARD The O funder O CW O took O part O in O the O formulation O and O development O of O methodology O and O provided O financial O support O for O this O study O This O work O was O jointly O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O No. O 31902318 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O No. O 2016YFD0501300 B-AWARD the B-ORG Program I-ORG for I-ORG Innovative I-ORG Research I-ORG Team I-ORG in I-ORG the I-ORG University I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG grant O No. O IRT_17R39 B-AWARD and O the B-ORG Foundation I-ORG for I-ORG Innovation I-ORG and I-ORG Strengthening I-ORG School I-ORG Project I-ORG of I-ORG Guangdong I-ORG China I-ORG grant O No. O 2016KCXTD010 B-AWARD The O study O is O supported O by O grants O from O the B-ORG Clinical I-ORG Special I-ORG Science I-ORG Fund I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BL2013006 O Six-Talent B-ORG Peak I-ORG Fund I-ORG of I-ORG Jiangsu I-ORG Province I-ORG WSW-063 O and O 333 B-ORG High-level I-ORG Personnel I-ORG Training I-ORG Project I-ORG Fund I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BRA2015051 O This O work O was O financially O supported O by O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Programs I-ORG of I-ORG China I-ORG 2013AA102504 O 2011BAD28B02 I-AWARD 2014ZX08009-053B O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 6152013 O the O Beijing B-ORG Dairy I-ORG Industry I-ORG Innovation I-ORG Team I-ORG BAIC06-2016 O the O earmarked O fund O for O Modern O Agro-industry O Technology O Research O System(CARS-37 O and O the O Program O for O Changjiang B-ORG Scholar I-ORG and I-ORG Innovation I-ORG Research I-ORG Team I-ORG in O University O IRT1191 O The O authors O would O also O like O to O appreciate O the O Dairy O Data O Center O of O China O for O providing O the O official O EBVs O data O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O Wellcome B-ORG Trust I-ORG A.C.N O Grant O 104571/Z/14 B-AWARD Z) O https://wellcome.ac.uk O European B-ORG Research I-ORG Council I-ORG G.H O Grant O PePe B-AWARD 323883 O https://erc.europa.eu O Economic B-ORG and I-ORG Social I-ORG Research I-ORG Council I-ORG T.W O Grant O ES/J500112/1 B-AWARD http://www.esrc.ac.uk O and O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG Oxford O Biomedical O Research O Centre O Programme O oxfbrc-2012-1 O http://oxfordbrc.nihr.ac.uk O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21868021 O the O Ordos B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 2021YY工119-49 O the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Hebei I-ORG Education I-ORG Department I-ORG QN2021090 O and O the O Science B-ORG Foundation I-ORG of I-ORG Hebei I-ORG Normal I-ORG University I-ORG l2021034 O This O study O was O supported O by O the O Sanming B-ORG Project I-ORG of I-ORG Medicine I-ORG in I-ORG Shenzhen I-ORG grant O No. O SZSM201612006 B-AWARD Shenzhen O Science O and O Technology O Innovation O Committee O JCYJ20180306171048616 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O No. O 81671669 B-AWARD 81227002 B-AWARD and O 81220108013 B-AWARD a O Youth B-ORG Technology I-ORG Grant I-ORG of I-ORG Sichuan I-ORG Province I-ORG No O 2017JQ0001 B-AWARD and O the O Program B-ORG for I-ORG Changjiang I-ORG Scholars I-ORG and I-ORG Innovative I-ORG Research I-ORG Team I-ORG PCSIRT O grant O No. O IRT1272 B-AWARD at O the O University O of O China O This O work O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61201117 B-AWARD the O National B-ORG Program I-ORG on I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG Nos O 2016YFC0104500 B-AWARD 2016YFC0104505 B-AWARD 2016YFC0103500 B-AWARD and O 2016YFC0103502 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O BK20151232 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Suzhou I-ORG No. O ZXY2013001 B-AWARD and O the O Youth B-ORG Innovation I-ORG Promotion I-ORG Association I-ORG CAS I-ORG No. O 2014281 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 31901690 B-AWARD the O Scientific O Research O Fund O Project O of O Department B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Sichuan I-ORG Province I-ORG grant O number O 2018JY0149 B-AWARD and O the O Scientific O Research O Foundation O of O Sichuan B-ORG Agricultural I-ORG University I-ORG grant O number O 03120321 B-AWARD The O authors O acknowledge O the O cooperation O of O all O the O participants O and O administrators O in O this O study O This O research O was O supported O by O the O Foundation O ofNational O Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China(Grant O NO: O 2016YFC0900803 B-AWARD and O theNatural O Science I-ORG Fund I-ORG of I-ORG Hubei I-ORG Province(Granter O number O 2018CFB634 B-AWARD Dr. O Guo O is O supported O by O Career O Development O Fellowship O APP1107107 B-AWARD from O the O AustralianNational O Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council(NHMRC O Dr. O S. O Li O is O supported O by O Early O Career O Fellowship O APP1109193 B-AWARD from O the O AustralianNHMRC O This O project O was O supported O by O the O Planning B-ORG Funds I-ORG of I-ORG Scientific I-ORG and I-ORG Technological I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2016B070701016 O and O 2017A050503005 B-AWARD and O the O Training B-ORG Fund I-ORG of I-ORG Guangdong I-ORG Institute I-ORG of I-ORG Applied I-ORG Biological I-ORG Resources I-ORG for I-ORG Postdoctoral I-ORG Researchers I-ORG NO.GIABR-pyjj201601 O the O Funds B-ORG for I-ORG Environment I-ORG Construction I-ORG and I-ORG Capacity I-ORG Building I-ORG of I-ORG GDAS’ I-ORG Research I-ORG Platform I-ORG 2016GDASPT-0107 O GDAS B-ORG Special I-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG 2017GDASCX-0107 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG 2017A030310425 O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81370673 B-AWARD the O Key B-ORG Medical I-ORG Subjects I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grant O No. O BL2014078 B-AWARD and O the B-ORG Key I-ORG Discipline I-ORG of I-ORG Jiangsu I-ORG Province I-ORG 2011-2015 O This O research O was O funded O by O European B-ORG Commission I-ORG through O the O European B-AWARD Regional I-AWARD Development I-AWARD Fund I-AWARD Centre I-AWARD of I-AWARD Excellence I-AWARD EcolChange O European B-ORG Research I-ORG Council I-ORG advanced O grant I-AWARD 322603 I-AWARD SIP-VOL O the O Estonian B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Education I-ORG institutional O grant I-AWARD IUT-8-3 O a O Villum O Foundation O Young O Investigator O Program O Fellowship O EHJN O Project B-AWARD No. I-AWARD 13167 O and O a O Danish O Independent O Research O Council O Post-Doctoral O Stipend O EHJN O Grant B-AWARD No. I-AWARD 6111 I-AWARD 00379B O This O study O was O funded O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81903078 O 81773208 B-AWARD 81891004 B-AWARD the B-ORG Capital I-ORG Characteristic I-ORG Clinical I-ORG Application I-ORG Research I-ORG and I-ORG Achievement I-ORG Promotion I-ORG Project I-ORG of I-ORG China I-ORG Z17110001017068 O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC0115604 O and O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDA16040000 O This O research O was O funded O by O the O key O project O of O Intergovernmental O International O Scientific O and O Technological O Innovation O Cooperation O in O China O under O Grant O No. O 2016YFE0128900 O China O Postdoctoral O Science O Foundation O Grant O No. O 2018M643667 O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O XJH012019018 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG for I-ORG the I-ORG Youth I-ORG of I-ORG China I-ORG No. O 11905170 B-AWARD Shaanxi O Province O Postdoctoral O Science O Foundation O Grant O No. O 2018104 O the O Fundamental O Research O Funds O for O the O Central O Universities O No. O XJH012019011 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O grant O No. O 11775166 B-AWARD and O National O key O R O O D O program O under O Grant O No. O 2017YFF0104201 O This O study O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG China I-ORG 81773115 O and O 31801187 B-AWARD the O SJTU B-ORG Interdisciplinary I-ORG Grant I-ORG YG2017MS52 O and O the O Jiangsu B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Plan I-ORG –Special I-ORG Funds I-ORG for I-ORG Transformation I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG BA2011069 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O is O supported O by O the O Abel O Tasman O Talent O Program O ATTP O of O the O University O of O Groningen O the O Guangdong B-ORG Province I-ORG General I-ORG University I-ORG Key I-ORG Research I-ORG Platform I-ORG and I-ORG Research I-ORG Program I-ORG 2018KQNCX084 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG Committee I-ORG 81901801 O to O SQ; O the O Dutch B-ORG Cancer I-ORG Society I-ORG grant I-ORG RUG B-AWARD 2010-4739 I-AWARD and O 2010 O Dutch B-ORG Pink I-ORG Ribbon I-ORG Foundation I-ORG grant I-ORG Male I-ORG Breast I-ORG to O CS; O and O the O PR B-ORG grant I-ORG 2010.WO25.C63 O The O funding O bodies O did O not O participate O in O the O design O of O the O study O the O collection O analysis O or O interpretation O of O the O data O the O writing O of O the O manuscript O or O the O decision O of O manuscript O submission O Financial O support O from O the O Deutsche B-ORG Forschungsgemeinschaft I-ORG DFG O Grant O No. O ME B-AWARD 3275/6 I-AWARD 1 I-AWARD and O MA B-AWARD 4079/10-1 O is O acknowledged O We O further O acknowledge O financial O support O from O the O Air B-ORG Force I-ORG Office I-ORG of I-ORG Scientific I-ORG Research I-ORG under O award O FA8655-21-1-7003 O M.S O and O M.S O thank O the O European B-ORG Research I-ORG Council I-ORG for O funding O Project O ERC-2014-CoG B-AWARD 646742 I-AWARD INCANA O This O work O was O supported O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG project O No. O 3332022168 B-AWARD the O 2020 B-ORG SKY I-ORG Imaging I-ORG Research I-ORG Fund I-ORG of I-ORG the I-ORG Chinese I-ORG International I-ORG Medical I-ORG Foundation I-ORG project O No. O Z-2014-07-2003-02 B-AWARD and O the O 2020 B-ORG Beijing I-ORG Hospital I-ORG “National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Preliminary I-ORG Research I-ORG Project” I-ORG project O No. O BJ-2020-131 B-AWARD This O research O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 62032013 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Nos O N2224001-7 B-AWARD and O N2116020 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province I-ORG No. O 2021-YGJC-24 B-AWARD This O work O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2019YFE0106000 O the O Key B-ORG projects I-ORG of I-ORG the I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Province I-ORG 20212ACB205012 O and O the O Technology B-ORG Innovation I-ORG Leading I-ORG Program I-ORG of I-ORG Jiangxi I-ORG 20212BDH80001 O which O are O gratefully O acknowledged O This O study O was O supported O by O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81560285 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG of I-ORG Jiangxi O China O Grant O No. O 20141BBG70026 O and O No. O 20132BBG70061 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG Project I-ORG of I-ORG Jiangxi O China O Grant O No. O 20132BAB205100 B-AWARD and O Graduate B-ORG Innovation I-ORG Foundation I-ORG of I-ORG Jiangxi O China O Grant O No. O YC2015-S082 B-AWARD This O work O was O supported O by O funding O from O Slovenian B-ORG Research I-ORG Agency I-ORG ARRS I-ORG Young I-ORG Researcher I-ORG Programme O Textile O Chemistry O Programme O P2-0118/0795 O P1-242 B-ORG Programme O and O project O “GO O DEFC” O Grant O number O N2-0087 B-AWARD and O the B-ORG Austrian I-ORG Science I-ORG Fund I-ORG FWF O Grant O number O I B-AWARD 3871-N37 O This O work O was O supported O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 2018SCUH0053 O the O Science B-ORG and I-ORG Technology I-ORG Major I-ORG Projects I-ORG of I-ORG Sichuan I-ORG Province I-ORG of I-ORG China I-ORG No.2017SZDZX0013 O and O the O Science B-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG of I-ORG Sichuan I-ORG Province I-ORG of I-ORG China I-ORG No.2016SZ0013 O This O study O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31300869 O 81471376 B-AWARD the O National O Basic O Research O Program O of O China O 973 O Program O 2014CB744600 O and O the B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG JiangSu I-ORG Province I-ORG Grants O No O BK20130415 B-AWARD The O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG #81201432 O 81371997 B-AWARD the O Army B-ORG Medical I-ORG Research I-ORG Subject I-ORG of I-ORG the I-ORG 12th I-ORG Five-Year-Plan I-ORG fund I-ORG #CWS11J275 O the O Scientific B-ORG Research I-ORG Fund I-ORG of I-ORG Hunan I-ORG Provincial I-ORG Education I-ORG Department I-ORG #15B140 O the O Hunan B-ORG Province I-ORG Health I-ORG and I-ORG Life I-ORG Committee I-ORG Scientific I-ORG Research I-ORG Project I-ORG #B2016148 O the O Military B-ORG Medical I-ORG Science I-ORG and I-ORG Technology I-ORG Youth I-ORG Training I-ORG Program I-ORG #2018JJ6033 O and O the O Hunan B-ORG Provincial I-ORG Innovation I-ORG Foundation I-ORG for I-ORG Postgraduates I-ORG #CX2015B185 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O financially O by O the O Central B-ORG Public-Interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG Freshwater I-ORG Fisheries I-ORG Research I-ORG Center I-ORG CAFS I-ORG No. O 2017JBFR01 B-AWARD the O Earmarked B-ORG Fund I-ORG for I-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG No. O CARS-45-05 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG CN) O No. O BK20160205 B-AWARD The O funding O bodies O had O no O role O in O the O experimental O design O sample O collection O data O analysis O and O interpretation O and O manuscript O writing O Sāo B-ORG Paulo I-ORG Research I-ORG Foundation I-ORG FAPESP O grant O numbers O 2015/12093-9 B-AWARD 2017/08463-0 B-AWARD 2015/19211-7 B-AWARD and O 2017/14764-3 B-AWARD the O National B-ORG Council I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Development I-ORG CNPq O grant O number O 401041/2016-6 B-AWARD and O Programa O Primeiros O Projetos O da O UNESP B-ORG grant O number O 12/2015-PROPe B-AWARD São O Paulo O State O Brazil O are O acknowledged O This O work O was O supported O by O the B-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Key I-ORG Project I-ORG of I-ORG Educational I-ORG Department I-ORG of I-ORG Henan I-ORG Province I-ORG No. O 16A520016 B-AWARD 17B520002 B-AWARD 17B520036 B-AWARD Key B-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Henan I-ORG Province I-ORG No. O 142102210056 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61402153 B-AWARD Project O funded O by O China O Postdoctoral O Science O Foundation O and O Ph.D B-ORG Research I-ORG Startup I-ORG Foundation I-ORG of I-ORG Henan I-ORG Normal I-ORG University I-ORG Nos O qd15130 B-AWARD qd15132 B-AWARD qd15129 B-AWARD None O the O funding O bodies O played O any O role O in O the O design O of O this O project O conclusion O of O this O study O or O collection O of O data O The O research O leading O to O these O results O has O received O funding O from O the O European B-ORG Research I-ORG Council I-ORG under O the O European O Union’s O Seventh O Framework O Programme O FP7/2007-2013)/ERC O grant I-ORG agreement O n° O 283871 B-AWARD and O the O Swiss B-ORG National I-ORG Science I-ORG Foundation I-ORG Social O learning O in O primate O communication O 31003A_166458 B-AWARD O Coordinating O joint O action O in O apes O Testing O the O boundaries O of O the O human O interaction O engine O CR31I3_159655 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O D.X O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 61301202 B-AWARD by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG no. O 2412016KJ014 B-AWARD and O by O Science O and O Technology O Development O Planning O of O Jilin O Province O D.P.M O was O partially O supported O by O EPSRC B-ORG grant O no. O EP/H026266/1 B-AWARD This O research O was O funded O by O a O grant O from O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG AI169344 O to O MR. O The O use O of O the O IMCA-CAT O beamline O 17-ID O at O the O Advanced O Photon O Source O was O supported O by O the O companies O of O the O Industrial O Macromolecular O Crystallography O Association O through O a O contract O with O Hauptman-Woodward O Medical O Research O Institute O Use O of O the O Advanced O Photon O Source O was O supported O by O the O U.S B-ORG Department I-ORG of I-ORG Energy I-ORG Office I-ORG of I-ORG Science I-ORG Office I-ORG of I-ORG Basic I-ORG Energy I-ORG Sciences I-ORG under O contract O no. O DE-AC02-06CH11357 B-AWARD This O research O used O resources O from O the O NYX O beamline O 19-ID O supported O by O the O New B-ORG York I-ORG Structural I-ORG Biology I-ORG Center O at O the O National O Synchrotron O Light O Source O II, O a O U.S O Department O of O Energy O DOE O Office O of O Science O User O Facility O operated O for O the O DOE O Office O of O Science O by O Brookhaven O National O Laboratory O under O Contract O No. O DE-SC0012704 B-AWARD The O NYX O detector O instrumentation O was O supported O by O grant O S10OD030394 B-AWARD through O the O Office B-ORG of I-ORG the I-ORG Director I-ORG of I-ORG the I-ORG National I-ORG Institutes I-ORG of I-ORG Health I-ORG This O study O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2019YFC1605700 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 30600603 O 31672548 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Henan I-ORG Province I-ORG 162300410129 O and O the O Doctoral B-ORG Scientific I-ORG Research I-ORG Start-up I-ORG Foundation I-ORG from I-ORG Henan I-ORG University I-ORG of I-ORG Chinese I-ORG Medicine I-ORG KYQD021 O This O research O was O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG No. O LY16H280002 B-AWARD Foundation B-ORG of I-ORG Zhejiang I-ORG Provincial I-ORG Department I-ORG of I-ORG Health I-ORG No. O 2019KY390 B-AWARD Medical B-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Provincial I-ORG Health I-ORG Commission I-ORG No. O 2019RC034 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81903849 B-AWARD and O Administration B-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG of I-ORG Zhejiang I-ORG Province I-ORG China I-ORG No. O 2018ZQ033 B-AWARD This O research O was O funded O by O National B-ORG Institute I-ORG on I-ORG Deafness I-ORG and I-ORG Other I-ORG Communication I-ORG Disorders I-ORG grant O numbers O K23 B-AWARD DC011056 I-AWARD M.G.-F O and O K23 B-AWARD DC010776 I-AWARD I.A.H O by O National B-ORG Institute I-ORG on I-ORG Aging I-ORG R01 B-AWARD AG011703 I-AWARD A.R.C O and O L.P.F O and O by O National B-ORG Center I-ORG for I-ORG Medical I-ORG Rehabilitation I-ORG Research I-ORG grant O number O 5 B-AWARD T32 I-AWARD HD007414-23 I-AWARD R.W.M O This O work O was O supported O by O the O Acre B-ORG Project—Health I-ORG in I-ORG the I-ORG Western I-ORG Amazonia I-ORG multi-institutional O agreement O process O n. B-AWARD 007/2015 I-AWARD SESACRE—UFAC—FMABC O the O São B-ORG Paulo I-ORG Research I-ORG Foundation I-ORG FAPESP O n. B-AWARD 2014/09774-1 O and O the O Health B-ORG National I-ORG Foundation—Rio I-ORG Branco I-ORG Government I-ORG agreement O n. B-AWARD 795710/2013 O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O is O resulted O from O the O Konkuk B-ORG University I-ORG research B-AWARD support I-AWARD program O This O paper O is O supported O by O the O Korea B-ORG National I-ORG Research I-ORG Foundation I-ORG NRF O grant O funded O by O the O Korean O government O MEST O NRF-2017R1A2B2004651 O This O paper O is O also O supported O by O National B-ORG Institute I-ORG for I-ORG Mathematical I-ORG Sciences I-ORG NIMS O grant O funded O by O the O Korea O government O MSIT O No. O B19610000 B-AWARD This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31472127 O the O Collaborative B-ORG Innovation I-ORG Project I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG CAAS-XTCX2016011-04-5 O and O the O National B-ORG Chicken I-ORG Industry I-ORG Technology I-ORG System I-ORG of I-ORG China I-ORG CARS-41 O This O research O was O funded O by O the O Andalusian O Regional O Government O Junta O de I-ORG Andalucía O under O the O Motriz O Program O project O No. O P11-TEP-7418 B-AWARD and O to O the O Spanish O Ministerio B-ORG de I-ORG Economía I-ORG y I-ORG Competitividad I-ORG and O Fondo B-ORG Europeo I-ORG de I-ORG Desarrollo I-ORG Regional I-ORG FEDER O projects O No. O AGL2015-65246-R B-AWARD and O AGL2017-83036-R B-AWARD This O work O was O funded O byNIHR O Maudsley O Biomedical O Research O Centregrant O Centre O for O Cognitive O Ageing O and O Cognitive O Epidemiology O University O of O Edinburghgrant O Medical O Research I-ORG Council10.13039/501100000265grantsMR/L501529/1andMR/R024804/1;Economic O and I-ORG Social I-ORG Research I-ORG Council10.13039/501100000269grantES/L008238/1;Euan O MacDonald O Centre O for O Motor O Neurone O Disease O Researchgrant O Wellcome O Trust10.13039/100004440grant083477/Z/07/Z;Motor O Neurone I-ORG Disease I-ORG Association10.13039/501100000406grantsCercignani/Oct12/865‐792,Gabel/Oct16/966‐799 O andLeigh/Apr14/824-791;Sylvia O Aitken O Charitable O Trustgrant O O This O study O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG projects I-ORG intergovernmental I-ORG cooperation I-ORG in I-ORG science I-ORG and I-ORG technology I-ORG of I-ORG China I-ORG 2018YFE0126900 O and O the O Provincial B-ORG and I-ORG ministerial I-ORG joint I-ORG construction I-ORG of I-ORG key I-ORG projects I-ORG No. O WKJ-ZJ-1932 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG Nos O LQ20H160056 B-AWARD LQ20H160055 O and O the O Public B-ORG welfare I-ORG projects I-ORG of I-ORG Zhejiang I-ORG Province I-ORG Nos O LGF19H180010 B-AWARD LGD19H160002 I-AWARD and I-AWARD LGF19H180009 O and O the O Medical B-ORG and I-ORG Health I-ORG Research I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG Nos O 2018KY933 B-AWARD and I-AWARD 2020KY380 O and O the O Key B-ORG R&D I-ORG Program I-ORG of I-ORG Lishui I-ORG City I-ORG No. O 2019ZDYF17 B-AWARD This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O nos O 51808508 B-AWARD and O U1704254 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG grant O no. O 2018M642786 B-AWARD and O Jiangsu B-ORG Key I-ORG Laboratory I-ORG for I-ORG Construction I-ORG Materials I-ORG grant O no. O CM2018-03 B-AWARD This O work O was O supported O by O 2021 B-ORG Anhui I-ORG Provincial I-ORG Health I-ORG Commission I-ORG Scientific I-ORG Research I-ORG Project I-ORG Grant O Number O AHWJ2021b097 B-AWARD 2022 B-ORG Provincial I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG Project I-ORG Grant O Number O 2022e07020050 B-AWARD and O Anhui B-ORG Medical I-ORG University I-ORG Scientific I-ORG Research I-ORG Fund I-ORG Grant O Number O 2020xkj057 B-AWARD This O study O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31772282 O and I-AWARD 31971703 O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD1000107 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018 O M640497 O and O Jiangsu B-ORG Postdoctoral I-ORG Science I-ORG Research I-ORG Foundation I-ORG 2018K216C O for O funding O this O research O This O work O was O supported O by O “The O regional O grant O in O the O field O of O science O and O technology” O of O the O Ministry B-ORG of I-ORG Education I-ORG and I-ORG Science I-ORG of I-ORG Samara I-ORG region O of O Russian O Federation O in O 2022 O project O No. O 32 B-AWARD partly O by O the O framework O of O the O program O “Structure O dynamics O and O sustainable O development O of O ecosystems O in O the O Volga O basin” O 1021060107217-0-1.6.19 B-AWARD conducted O by O Institute B-ORG of I-ORG Ecology I-ORG Branch I-ORG of I-ORG Samara I-ORG Federal I-ORG Research I-ORG Scientific I-ORG Center I-ORG of I-ORG RAS I-ORG Volga I-ORG River I-ORG Basin I-ORG of I-ORG RAS O and O partly O by O the O framework O of O the O of O the O program O “Mechanisms O of O physiological O and O genetic O control O of O cellular O organelle O interactions O and O development O of O principles O for O their O directed O modifications” O 122041100052-0 B-AWARD conducted O by O Siberian B-ORG Institute I-ORG of I-ORG Plant I-ORG Physiology I-ORG and I-ORG Biochemistry I-ORG Financial O support O of O this O work O by O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG the I-ORG Republic I-ORG of I-ORG China I-ORG MOST111-2320-B-037-021-MY3 O Research O Foundation O M111005 O 110KK008 B-AWARD 111KK017 B-AWARD from O Kaohsiung B-ORG Medical I-ORG University O Kaohsiung O Taiwan O the O Department B-ORG of I-ORG Pharmacy I-ORG Kaohsiung I-ORG Municipal I-ORG Ta-Tung I-ORG Hospital O Kaohsiung O Taiwan O kmtth-110-036 O kmtth-111-022 B-AWARD are O gratefully O acknowledged O We O also O thank O the O Center O for O Research O Resources O and O Development O at O Kaohsiung O Medical O University O for O instrumentation O and O equipment O support O This O study O was O supported O in O part O by O National B-ORG key I-ORG research I-ORG and I-ORG development I-ORG program I-ORG 2016YFD0102002 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O http://www.nsfc.gov.cn/publish/portal1 O 31271723 O to O DL O The B-ORG Key I-ORG Projects I-ORG of I-ORG Sichuan I-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG 16ZA0028 O to O MH O and O The B-ORG Youth I-ORG Fund I-ORG of I-ORG the I-ORG Sichuan I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG 2016QNJJ-008 O to O JL O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O by O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG MOST O grants O MOST O 103-2627-M-007-006 I-AWARD and O MOST B-AWARD 107-0210-01-19-04 O to O Dr. O Margaret O Dah-Tsyr O Chang O as O well O as O by O Simpson O Biotech O Co O Ltd O Taiwan O The O research O was O also O supported O by O the O EU O and O co-financed O by O the O European B-ORG Regional I-ORG Development I-ORG Fund I-ORG under O the O projects O GINOP-2.3.2-15-2016-00008 B-AWARD A. O B.) O and O by O the O ÚNKP-18-3 B-AWARD New I-AWARD National I-AWARD Excellence I-AWARD Program I-AWARD of O the O Ministry B-ORG of I-ORG Human I-ORG Capacities I-ORG of I-ORG Hungary I-ORG F. O D O This O work O was O supported O by O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81773510 O Nature B-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province I-ORG No. O 20170541048 O and O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Grant O 2017YFC1307600 O This O work O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O 52277138 B-AWARD and O in O part O by O the O Natural O Science O Foundation O of O China O under O Grant O 51867003 B-AWARD Our O thanks O to O the O support O of O the O China B-ORG Postdoctoral I-ORG Foundation O 2022MD713732 B-AWARD This O research O was O funded O by O grants O from O the O NSF O National O Science I-ORG Foundation O under O grant O DMS-1312543,https://www.nsf.gov/awardsearch/showAward?AWD_ID=1312543 B-AWARD the O NIGMS O National O Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences O under O grant O 1R01 B-AWARD GM126556),https://www.nigms.nih.gov/Pages/default.aspx O and O by O a O research O fellowship O from O the O Alfred O P. O Sloan O Foundation O SSC O was O supported O by O the O National O Institutes O of O Health O NIH O under O a O Ruth O L. O Kirschstein O National O Research O Service O Award O T32-GM008185,http://www.biomath.ucla.edu/huang/sibtp O TKH O received O funding O from O National B-ORG Institute I-ORG of I-ORG Health I-ORG NIH O under O grant O numbers O R01 O HL083015 O R01 O HL129727 O and O R01 O HL111437 O https://www.nih.gov O SPLH O received O funding O from O MOST O Ministry O of O Science O and O Technology O Taiwan O under O grant O MOST O 105-2313-B-005-MY3,https://arspb.most.gov.tw/NSCWeb/wSite/mp?mp=11&token=ZVj37+cQGrJIZINi O VMS O received O funding O from O the O US O National O Science O Foundation O ID: O 1254159,http://nsf.gov O The O contents O of O this O paper O are O solely O the O responsibility O of O the O authors O and O do O not O necessarily O represent O the O official O views O of O the O NIH O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O financed O partly O by O the O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG of I-ORG Brazil I-ORG CAPES O Finance O Code O 001 B-AWARD The O authors O wish O to O thank O the O Brazilian O agencies O the O CNPq B-ORG Universal I-ORG Project I-ORG 422015/2018-0 B-AWARD C.R.M.A O and O the O FAPESP B-ORG São O Paulo O Research O Foundation O for O financial O support O through O “Projeto O Temático” O B-AWARD 2018/18293-8 I-AWARD and O post-doc O Grant O B-AWARD 2019/26517-6 I-AWARD P.A.B.K O This O work O was O supported O by O the B-ORG Key I-ORG Special I-ORG Projects I-ORG of I-ORG the I-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG the I-ORG 13th I-ORG Five-Year I-ORG Plan I-ORG No. O 2016YFC0500300 B-AWARD the B-ORG Jilin I-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Program I-ORG Project I-ORG Nos O 20160307005YY B-AWARD 20170204017YY B-AWARD the B-ORG Public I-ORG Welfare I-ORG Industry I-ORG Agriculture I-ORG Research I-ORG Project I-ORG No. O 201303111 B-AWARD This O project O was O supported O by O Award O Number O UL1TR001876 B-AWARD from O the O NIH B-ORG National I-ORG Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences O It O was O also O supported O by O ANID-PAI B-ORG 82140008 B-AWARD ANID-FONDECYT B-ORG Regular O 1200834 B-AWARD and O ANID-PIA-Anillo B-ORG INACH O ACT192057 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O founded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grants O Nos O U19B2030 B-AWARD 61976167 B-AWARD and O 82230065 B-AWARD the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG in I-ORG the I-ORG Shaanxi I-ORG Province I-ORG of I-ORG China I-ORG under O Grant O No. O 2021GY-082 B-AWARD and O the O Scientific B-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Education I-ORG Department I-ORG of I-ORG Shaanxi I-ORG Provincial I-ORG Government I-ORG under O Grant O No. O 20JG031 B-AWARD This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O number O 2018YFA0801000 B-AWARD the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Grant O No. O XDA24010308 B-AWARD and O XDA24010206 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31801055 B-AWARD This O work O has O been O partially O supported O by O a O National B-ORG 973 I-ORG Program I-ORG No. O 2015CB755401 B-AWARD of O China O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21407145 O 31400625 I-AWARD 61605206 O and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFF0106303 O 2016YFC0101300 I-AWARD 2016YFC0101002 O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31670074 O and O 21661140002 B-AWARD the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC1600105 O Shanghai B-ORG Science I-ORG I-ORG Technology I-ORG Specific I-ORG Projects I-ORG 124119a6100 O and O the O Medicine B-ORG and I-ORG Engineering I-ORG Interdisciplinary I-ORG Research I-ORG Fund I-ORG of I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG YG2015MS59 O This O study O was O supported O by O the O National B-ORG Social I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 17CTY020 O 20BTY004 B-AWARD Beijing B-ORG Social I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21YTA009 O and O the O Tsinghua B-ORG University I-ORG “Shuang I-ORG Gao” I-ORG Scientific I-ORG Research I-ORG Program I-ORG 2021TSG08208 O the O Tsinghua B-ORG Education I-ORG Reform I-ORG Project I-ORG 2021ZY01_01 O the O Tsinghua B-ORG Graduated I-ORG Education I-ORG Reform I-ORG Project I-ORG 202303J039 O This O research O was O funded O by O The B-ORG Executive I-ORG Agency I-ORG for I-ORG Financing I-ORG of I-ORG Higher I-ORG Education I-ORG Research I-ORG Development I-ORG and I-ORG Innovation I-ORG UEFISCDI I-ORG Romania I-ORG under O contract O no. O PCE B-AWARD 117/2022—COMCONF O A.-M O Brezoiu’s O work O has O been O funded O by O the O European B-ORG Social I-ORG Fund I-ORG from O the O Sectoral O Operational O Program O Human O Capital O 2014–2020 O through O the O Financial O Agreement O with O the O title O “Training O of O Ph.D O students O and O postdoctoral O researchers O in O order O to O acquire O applied O research O skills–SMART” O Contract O no. O 13530/16.06.2022–SMIS B-AWARD code O 153734 O M. O Cîlțea-Udrescu’s O and O E. O Alexandrescu’s O work O has O been O funded O by O the O PN O 23.06 O Core O Program–ChemNewDeal O within O the O National O Plan O for O Research O Development O and O Innovation O 2022–2027 O developed O with O the O support O of O the O Ministry B-ORG of I-ORG Research I-ORG Innovation I-ORG and I-ORG Digitization O project O no. O PN B-AWARD 23.06.02.01–InteGral I-AWARD This O project O was O partially O supported O by O the O National B-ORG Institute I-ORG of I-ORG Health I-ORG 3R25CA057711 B-AWARD Its O contents O are O solely O the O responsibility O of O the O authors O and O do O not O necessarily O represent O the O official O views O of O the O NIH O The O development O of O the O manuscript O was O partially O supported O by O Cancer B-ORG Disparities I-ORG Research I-ORG Network/Geographic I-ORG Management I-ORG Program I-ORG GMaP I-ORG Region I-ORG 4 I-ORG funded O by O 3 B-AWARD P30 I-AWARD CA006927-52S2 I-AWARD and O CTSI B-ORG Mentored I-ORG Career I-ORG Development I-ORG Award I-ORG KL2 O TR002545 O The O funders O did O not O influence O the O design O of O the O study O and O collection O analysis O nor O the O interpretation O of O data O and O writing O the O manuscript O This O work O was O financially O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFB0300801 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51871043 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG N180212010 O China O This O work O was O supported O financially O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 40218030034 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG grant O number O 2019M652309 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG grant O number O ZR2018BC001 B-AWARD This O research O was O supported O by O a O Medical B-ORG Research I-ORG Council-Economic I-ORG and I-ORG Social I-ORG Research I-ORG Council I-ORG MRC-ESRC O interdisciplinary O award O grant O award O number O G0901455 B-AWARD and O a O British B-ORG Academy I-ORG small O grant O SG100322 O Nuriye O Kupeli O is O supported O by O Marie B-ORG Curie I-ORG Cancer I-ORG Care I-ORG core O grant O funding O MCCC-FCO-16-U O This O research O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 22071080 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jilin I-ORG Province I-ORG YDZJ202101ZYTS175 O and O the O Scientific B-ORG Research I-ORG Fund I-ORG of I-ORG Education I-ORG Department I-ORG of I-ORG Jilin I-ORG Province I-ORG No. O JJKH20210236KJ B-AWARD JJKH20220234KJ B-AWARD This O research O was O funded O by O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq O Grant O Numbers O 403229/2016-2 B-AWARD and O 400412/2014-4 B-AWARD Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG Minas I-ORG Gerais I-ORG FAPEMIG O Grant O Numbers O 01927-16 B-AWARD and O 01446-14 B-AWARD and O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG CAPES)—Finance O Code O 001 B-AWARD This O study O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China,(No.81570584 O Social B-ORG development I-ORG project I-ORG of I-ORG Jiangsu I-ORG Province(BE2015685)and O Medical B-ORG Research I-ORG Funding I-ORG of I-ORG PLA(AWS14C003 O This O work O was O supported O by O Grant O 81572044 O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O “the O Fundamental O Research O Funds O for O the O Central O Universities” O from O the O Key O Laboratory O of O Molecular O Microbiology O and O Technology O Ministry O of O Education O TEDA O Institute O of O Biological O Sciences O and O Biotechnology O Nankai O University O and O by O Grants O 125684 B-AWARD from O the O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG China-Canada O Joint O Health O Research O Initiative O and O 154280 B-AWARD from O the O Natural B-ORG Sciences I-ORG and I-ORG Engineering I-ORG Research I-ORG Council I-ORG of I-ORG Canada I-ORG This O study O was O supported O by O the O Shenzhen B-ORG Sanming I-ORG Project I-ORG SZSM201512039 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82101115 O and O the O Wuhan B-ORG University I-ORG Independent I-ORG Innovation I-ORG Fund I-ORG Young I-ORG Teacher I-ORG Project I-ORG 2042021kf0094 O This O work O was O funded O by O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 3072019CF2516 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG LC2018026 O 111 B-ORG project I-ORG B13015 O to O the O Harbin O Engineering O University O This O work O was O supported O by O grants O from O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81772942 B-AWARD to O C.Y O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 O Program O No. O 2015CB553800 B-AWARD to O C.Y O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG China I-ORG 2017ZX10203206 O to O W. O L), O Scientific B-ORG Research I-ORG Foundation I-ORG for I-ORG Advanced I-ORG Talents I-ORG Xiang’an I-ORG Hospital I-ORG of I-ORG Xiamen I-ORG University I-ORG No. O PM20180917008 B-AWARD to O W. O L), O and O Open B-ORG Research I-ORG Fund I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Cellular I-ORG Stress I-ORG Biology I-ORG Xiamen I-ORG University I-ORG No. O SKLCSB2019KF006 B-AWARD to O X.X O Scientific B-ORG Research I-ORG Foundation I-ORG for I-ORG Doctor I-ORG Xiamen I-ORG Medical I-ORG College I-ORG No. O K2016-12 B-AWARD to O X.X O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U1804176 O the O key O projects O funded O by O the O Education B-ORG Department I-ORG of I-ORG Henan I-ORG Province I-ORG 18A350005 O and O the O key O project O funded O by O the O Science B-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Henan I-ORG Province I-ORG 182102210236 O This O work O was O financially O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 41877003 B-AWARD National B-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG grant O numbers O 2015BAD23B0202 B-AWARD and O Funds B-ORG of I-ORG Shandong I-ORG “Double I-ORG Tops” I-ORG Program I-ORG SYL2017XTTD02 O This O research O was O supported O by O grants O from O the O NIH/NIA B-ORG R01AG062496 O to O A.K O Agencia B-ORG Nacional I-ORG de I-ORG Investigación I-ORG y I-ORG Desarrollo O Chilean O Government O FONDECYT O 1181780 I-AWARD to O R.V O and O Millennium B-ORG Science I-ORG Initiative I-ORG from I-ORG Ministry I-ORG for I-ORG the I-ORG Economy I-ORG Development I-ORG and I-ORG Tourism O Chile O P09/016-F O to O M.G O Carla O Alvarez O is O an O awardee O of O the O fellowship O CONICYT O 21161255 O from O the O Chilean O Government O This O work O is O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG under O grant O 2017YFB1002502 B-AWARD the O Key B-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61731003 O the O National O Natural O Science O Foundation O of O China O 61671067 O 61473044 B-AWARD the O Interdiscipline O Research O Funds O of O Beijing O Normal O University O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2017XTCX04 O This O research O was O supported O by O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2016JX05 O Forestry B-ORG Public I-ORG Welfare I-ORG Projects I-ORG Special I-ORG Fund I-ORG of I-ORG China I-ORG 201304301 O and O Beijing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG Z141100006014031 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 61875092 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG of I-ORG Tianjin O the O grant O number O 17YFZCSY00740 B-AWARD and O the O Beijing-Tianjin-Hebei B-ORG Basic I-ORG Research I-ORG Cooperation I-ORG Special I-ORG Program O grant O number O 19JCZDJC65300 B-AWARD In O this O work O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O are O funded O by O the O National B-ORG High-tech I-ORG Research I-ORG and I-ORG Development I-ORG Projects I-ORG of I-ORG China I-ORG under O Grant O No: O 2014AA041505 B-AWARD and O the O writing O of O the O manuscript O is O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O No: O 61572238 B-AWARD and O by O the O Provincial B-ORG Outstanding I-ORG Youth I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG under O Grant O No: O BK20160001 B-AWARD The O authors O are O grateful O to O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant B-AWARD No. I-AWARD 61704034 O the O Pearl O River O S&T O Nova O Program O of O Guangzhou O Grant O No. O 201906010058 O the O Key B-ORG Platforms I-ORG and I-ORG Research I-ORG Projects I-ORG of I-ORG Department I-ORG of I-ORG Education I-ORG of I-ORG Guangdong I-ORG Province I-ORG Grant B-AWARD No. I-AWARD 2016KTSCX034 O the O Guangdong B-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Grant B-AWARD No. I-AWARD 2017B010123002 I-AWARD and O the O Natural O Science O Foundation O of O Guangdong O Province O Grant O Nos O 2018A0303130199 O and O 2017A030313632 O This O study O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32060203 O and O 81860283 B-AWARD Funds B-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG Jiangxi I-ORG Province I-ORG 20195050 O and O The B-ORG 555 I-ORG project I-ORG of I-ORG Jiangxi I-ORG Province I-ORG Gan I-ORG Po I-ORG Excellence I-ORG 18000066 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG to O DSB O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo I-ORG 2015/06281-7 B-AWARD to O MM O and O 2013/03236-5 B-AWARD to O ACL O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG 302849/2015-7 B-AWARD to O ACL O and O National O Institute O of O Health O 1R01HD084542 B-AWARD and O 8P51OD011092 B-AWARD for O the O operation O of O the O Oregon B-ORG National I-ORG Primate I-ORG Research I-ORG Center I-ORG to O SRO O and O AL O This O research O was O supported O by O Advanced B-AWARD Low I-AWARD Carbon I-AWARD Technology I-AWARD Research I-AWARD and I-AWARD Development I-AWARD Program I-AWARD from O Japan B-ORG Science I-ORG and I-ORG Technology I-ORG Agency I-ORG T.K O by O Research B-AWARD Scholarships I-AWARD from O the O Ministry B-ORG of I-ORG Education I-ORG Culture I-ORG Sports I-ORG Science I-ORG and I-ORG Technology O Japan O N.J.R O and O by O Research B-AWARD Fellowships I-AWARD for I-AWARD Young I-AWARD Scientists I-AWARD from O Japan B-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG K.K O The O authors O gratefully O acknowledge O funding O from O the O Australian O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG Project O Grant I-AWARD 1048216 O and O the O iVEC/Pawsey B-ORG Supercomputing I-ORG Centre I-ORG with O funding O from O the O Australian O Government O and O the O Government O of O Western O Australia O PN/14/736 B-AWARD and I-AWARD PN/15/1007 O The O salary O of O BHM O is O supported O by O a O Raine B-ORG Medical I-ORG Research I-ORG Foundation I-ORG Priming B-AWARD Grant I-AWARD This O review O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81572608 B-AWARD Wuhan B-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG No. O 2017060201010170 B-AWARD KW O and O the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2015AA020301 B-AWARD This O study O was O funded O by O the O Technology B-ORG Commission I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2013B020304002 O Modern B-ORG Agricultural I-ORG Industry I-ORG Technology I-ORG System I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2016LM1128 O Special B-ORG Fund I-ORG for I-ORG Agro-scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG 201303021 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31572089 O The O funders O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grants O 61772176 B-AWARD 61402153 B-AWARD 61370169 B-AWARD and O U1604154 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O 2016M602247 B-AWARD the O Plan O for O Scientific O Innovation O Talent O of O Henan O Province O Grant O 184100510003 O the O Key O Scientific O and O Technological O Project O of O Henan O Province O Grants O 182102210362 O and O 182102210078 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Henan I-ORG Province I-ORG Grants O 182300410130 B-AWARD 182300410368 B-AWARD and O 182300410306 O and O the O Ph.D O Research O Foundation O of O Henan O Normal O University O Grant O qd15132 O This O study O was O funded O by O the O 1·3·5 O projects O for O disciplines O of O excellence—Clinical O Research O Incubation O Project O West B-ORG China I-ORG Hospital I-ORG Sichuan I-ORG University I-ORG 2020HXFH036 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82002638 O the O Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG 23NSFSC0852 O This O work O was O in O part O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81770410 O and O 81401324 B-AWARD Scientific B-ORG Program I-ORG for I-ORG Young I-ORG teacher I-ORG of I-ORG Sun I-ORG Yat-sen I-ORG University(16ykpy05 O the O National O Natural O Science O Foundation O of O China O China O 81370574 O and O 81670591 B-AWARD Guangdong B-ORG Natural I-ORG Science I-ORG Foundation I-ORG China I-ORG 2016A030311028 O and O the O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG China I-ORG 201704020073 O This O study O was O funded O by O the O Special B-ORG Foundation I-ORG for I-ORG State I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2013FY110500,2013FY110511 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Youth I-ORG 81601343 O and O the O National B-ORG Key I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2012BAI32B02 O This O work O was O financially O supported O by O grants O from O the B-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG of I-ORG Tianjin I-ORG 19ZXDBSY00060 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81772464 O and O the B-ORG Tianjin I-ORG Key I-ORG Project I-ORG of I-ORG Natural I-ORG Science I-ORG Foundation I-ORG No.17JCZDJC36200 O The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFA0606200 O Guangzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 201704020194 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG China I-ORG 2019A1515011880 O and O Guangdong O Health O Innovation O Platform O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81572150 O 81301636 B-AWARD Hunan B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG CN) I-ORG 2017SK2063 O and O the O Health B-ORG Commission I-ORG of I-ORG Hunan I-ORG Province I-ORG 20180961 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 31370591 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG grant O no. O DL13CA07 B-AWARD Postdoctoral B-ORG Science I-ORG Start-up I-ORG Foundation I-ORG of I-ORG the I-ORG Heilongjiang I-ORG Province I-ORG grant O no. O LBH-Q14012 B-AWARD This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31602135 O 31402287 I-AWARD to O WH O the O Guangdong B-ORG Province I-ORG Program I-ORG 2013B091300020 O 2014B030301064 I-AWARD 2015B020231007 I-AWARD 2016A020210062 I-AWARD 2016A030310112 I-AWARD 2017B030314052 I-AWARD to O CH O and O the B-ORG Science I-ORG I-ORG Technology I-ORG Promoting I-ORG Projects I-ORG for I-ORG Oceanic I-ORG I-ORG Fishery I-ORG in I-ORG Guangdong I-ORG Province I-ORG A201601A03 O to O CH O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 32201602 B-AWARD the O Natural B-ORG Science I-ORG Fund I-ORG Youth I-ORG Project I-ORG of I-ORG Hunan I-ORG Province I-ORG Grant O No. O 2021JJ41067 B-AWARD and O the O Outstanding B-ORG Youth I-ORG of I-ORG the I-ORG Education I-ORG Department I-ORG of I-ORG Hunan I-ORG Province I-ORG Grant O No. O 20B624 B-AWARD Support O for O this O work O was O received O through O funding O from O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG 5K08GM081459-03 O to O KS, O a O seed O grant O Department O of O Anesthesiology O and O Perioperative O Medicine O Penn O State O Health O to O KS, O funding O from O the O National B-ORG Institute I-ORG of I-ORG Diabetes I-ORG and I-ORG Digestive I-ORG and I-ORG Kidney I-ORG Diseases I-ORG 5R01DK070910 O to O JAK O and O funding O from O the O National B-ORG Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute I-ORG 5R01HL080926 O to O JAK O This O work O was O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0501305 O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-41-G13 O and O Technical B-ORG Innovation I-ORG Project I-ORG of I-ORG Hubei I-ORG Province I-ORG 2018ABA108 O The O funders O had O no O role O in O study O design O data O collection O analysis O and O interpretation O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O National B-ORG Institutes I-ORG of I-ORG Health O grant O number O CA216017 B-AWARD CA204120 I-AWARD CA196530 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 91546202 B-AWARD 71331006 O Bureau B-ORG of I-ORG Statistics I-ORG of I-ORG China O grant O number O 2018LD02 B-AWARD This O work O was O financially O supported O by O the B-ORG earmarked I-ORG fund I-ORG for I-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-14 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31471537 O the B-ORG Plan I-ORG for I-ORG Scientific I-ORG Innovation I-ORG Talent I-ORG of I-ORG Henan I-ORG Province I-ORG 184200510002 O the B-ORG Key I-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG in I-ORG Henan I-ORG Province I-ORG 151100111200 O the B-ORG Importing I-ORG International I-ORG Agricultural I-ORG Sciences I-ORG and I-ORG Technology I-ORG Program I-ORG 2016-X05 O the B-ORG Henan I-ORG Province I-ORG Specific I-ORG Professor I-ORG Position I-ORG Program I-ORG SPPP2016 O the B-ORG Distinguished I-ORG Professor I-ORG Program I-ORG of I-ORG Institutions I-ORG of I-ORG Higher I-ORG Learning I-ORG in I-ORG Henan I-ORG Province I-ORG DPPIHL2017 O and O the B-ORG Innovation I-ORG Scientists I-ORG and I-ORG Technicians I-ORG Troop I-ORG Construction I-ORG Projects I-ORG of I-ORG Henan I-ORG Province I-ORG ISTTCPHP2016 O Research O was O supported O by O Institutional O Research O Grant O 124166-IRG-58-001-55-IRG21 O from O the O American B-ORG Cancer I-ORG Society I-ORG https://www.cancer.org O A.E O Prizment O was O supported O by O the O National B-ORG Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences I-ORG of O the O NIH O Award O Number O UL1 B-AWARD TR000114 I-AWARD https://www.nih.gov O B.W O R01CA203348 B-AWARD from O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG https://www.nih.gov O The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O National O Institutes O of O Health O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Engineering B-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG EP/H013016/1),https://www.epsrc.ac.uk O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG BB/J018007/1),http://www.bbsrc.ac.uk O European B-ORG Research I-ORG Council O 323041),https://erc.europa.eu O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 51408538 B-AWARD 51338008 I-AWARD 51278454 O Key B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Team I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2013TD09 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities O 2015QNA4025 O and O State B-ORG Key I-ORG Development I-ORG Program I-ORG for I-ORG Basic I-ORG Research I-ORG of I-ORG China I-ORG Grant O No.2012CB725402 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 22172020 B-AWARD 61974020 B-AWARD and O 22241201 B-AWARD This O work O is O also O supported O by O the O projects B-ORG of I-ORG Sci I-ORG and I-ORG Tech I-ORG planning I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2021ZHCG0002 O the O Innovation B-ORG Team I-ORG Project I-ORG of I-ORG Zhuhai I-ORG City I-ORG No. O ZH0405190005PWC B-AWARD and O the O projects B-ORG of I-ORG Sci I-ORG and I-ORG Tech I-ORG planning I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2019B090910003 B-AWARD and O Zhuhai O City O No. O M17ZH220170000032PWC B-AWARD The O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81701178 B-AWARD Project O funded O by O China O Postdoctoral O Science O Foundation O No. O 2019M662439 O Sci-Tech B-ORG Development I-ORG Project I-ORG of I-ORG Taian I-ORG in I-ORG Shandong I-ORG No. O 2018NS0176 B-AWARD Medical B-ORG and I-ORG Health I-ORG Development I-ORG Project I-ORG of I-ORG Shandong I-ORG No. O 2018WS145 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82270646 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 0214-14380510 O and O the O Nanjing B-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Project I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG JQX19002 O The O clinical O trials O were O funded O by O the O Affiliated B-ORG Drum I-ORG Tower I-ORG Hospital I-ORG Medical I-ORG School I-ORG of I-ORG Nanjing I-ORG University I-ORG 2022-LCYJ-PY-35 O Project B-ORG of I-ORG Modern I-ORG Hospital I-ORG Management I-ORG and I-ORG Development I-ORG Institute I-ORG Nanjing I-ORG University I-ORG and I-ORG Aid I-ORG project I-ORG of I-ORG Nanjing I-ORG Drum I-ORG Tower I-ORG Hospital I-ORG Health I-ORG Education I-ORG I-ORG Research I-ORG Foundation I-ORG NDYG2022057 O and O the O Chen B-ORG Xiao-ping I-ORG Foundation I-ORG for I-ORG the I-ORG Development I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Hubei I-ORG Province I-ORG China I-ORG CXPJJH121001-2021073 O This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81501705 B-AWARD National O Natural O Science O Foundation O of O China O Grant O No. O 81671892 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grant O No. O BK20161433 B-AWARD and O Key B-ORG Medical I-ORG Subjects I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grant O No. O ZDXKA2016025 B-AWARD The O funding O bodies O have O no O roles O in O the O design O of O the O study O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O study O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81170876 O 31600971 I-AWARD 81320108010 O Shanghai B-ORG Municipal I-ORG Education I-ORG Commission-Gaofeng I-ORG Clinical I-ORG Medicine I-ORG Grant I-ORG Suppport I-ORG 20152228 O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 863 O Program O 2015AA020311 O Shanghai B-ORG Municipal I-ORG Hospital I-ORG Emerging I-ORG Frontier I-ORG Technology I-ORG Joint I-ORG Project I-ORG SHDC12012107 O and O Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG Research I-ORG Project I-ORG 16411950600 O 14411968000 O JJ: O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG 863 O Program I-AWARD No. I-AWARD 2011AA100305 O CG: O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31260532 O SZ: O Yunnan B-ORG Provincial I-ORG Natural I-ORG Science I-ORG foundation I-ORG research I-ORG projects I-ORG 2009CD060 O and I-AWARD 2011FA015 O The O funding O bodies O had O no O role O in O the O design O of O the O study O data O collection O analyses O and O interpretation O of O the O data O and O in O writing O the O manuscript O This O research O was O sponsored O by O São B-ORG Paulo I-ORG Research I-ORG Foundation I-ORG FAPESP O grants O 2014/22451–7 O and O 2016/16437–7 B-AWARD the O National B-ORG Institute I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG in I-ORG Pharmaceutical I-ORG Nanotechnology—INCT I-ORG NANOFARMA I-ORG FAPESP O grant O number O 2014/50928–2 B-AWARD and O CNPq B-ORG grant O number O 465687/2014–8 B-AWARD and O the O Coordination B-ORG of I-ORG Improvement I-ORG of I-ORG Higher I-ORG Education I-ORG Personnel—CAPES I-ORG grant O number O 001 B-AWARD This O paper O was O partially O sponsored O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O No.81160248 B-AWARD and I-AWARD 81560464 I-AWARD DYL O and O No. B-AWARD 81360313 I-AWARD ZQL O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Province O No. B-AWARD 20151BAB205058 I-AWARD DYL O and O No. B-AWARD 20171BAB205055 I-AWARD ZQL O and O the O Scientific B-ORG Research I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Province I-ORG Education I-ORG Department O No. B-AWARD GJJ160103 I-AWARD ZQL O ACCH O received O the O following O fundings O Grant O CM05 B-AWARD from O the O University B-ORG of I-ORG Buenos I-ORG Aires O PIP0051 B-AWARD from O the O National B-ORG Council I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Investigation O PICT B-AWARD 2012-2598 I-AWARD from O the O National B-ORG Agency I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Technology I-ORG and I-ORG Science I-ORG This O research O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0501200 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31772565 O Sailing B-ORG Plan I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2014YT02H042 O and O National B-ORG Swine I-ORG Industry I-ORG Technology I-ORG System I-ORG CARS–36 O This O study O was O supported O by O grants O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O number O 2016YFC0800705 B-AWARD the O Shanghai B-ORG Forensic I-ORG Service I-ORG Platform I-ORG grant O number O 16DZ2290900 B-AWARD and O the O Shanghai B-ORG Key I-ORG Laboratory I-ORG of I-ORG Forensic I-ORG Medicine I-ORG grant O number O 17DZ2273200 B-AWARD This O work O was O carried O out O at O the O school O of O geology O engineering O and O geomatics O at O Chang’an O University O and O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41772277 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2020T130567 O 2016M602736 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 2020JQ-373 O and O the O Fundamental O Research O Funds O for O the O Central O Universities O CHD O 300102269107 O 300102269401 O This O work O is O supported O in O part O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81172283 B-AWARD and O 81372616 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG No. O 2012D037 B-AWARD Fujian B-ORG Provincial I-ORG Medical I-ORG Innovation I-ORG Project I-ORG No. O 2017-CXB-15 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Xiamen I-ORG No. O 3502Z20174076 B-AWARD This O work O received O financial O support O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31730067 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG JUSRP51706A O National B-ORG First-Class I-ORG Discipline I-ORG Program I-ORG of I-ORG Light I-ORG Industry I-ORG Technology I-ORG and I-ORG Engineering I-ORG LITE2018-03 O 111 B-ORG Project I-ORG No. O 111-2-06 B-AWARD Fundamental O Research O Funds O for O the O Central O Universities O JUSRP11968 O The O work O was O supported O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2020YFA0908800 O NSFC B-ORG 81573279 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG China I-ORG 2042021kf1033 O This O work O was O supported O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81702870 O Science B-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG of I-ORG Suzhou I-ORG No. O SYS201749 B-AWARD Jiangsu B-ORG Provincial I-ORG Medical I-ORG Youth I-ORG Talent I-ORG No. O QNRC2016746 B-AWARD Societal B-ORG and I-ORG Developmental I-ORG Project I-ORG of I-ORG Suzhou I-ORG No. O SS201862 B-AWARD Suzhou B-ORG Key I-ORG Laboratory I-ORG for I-ORG Respiratory I-ORG Medicine I-ORG No. O SZS201617 B-AWARD Clinical B-ORG Medical I-ORG Center I-ORG of I-ORG Suzhou I-ORG No. O Szzx201502 B-AWARD Jiangsu B-ORG Provincial I-ORG Key I-ORG Medical I-ORG Discipline I-ORG No. O ZDXKB2016007 B-AWARD and O Clinical O Key O Specialty O Project O of O China O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 71601072 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Universities I-ORG of I-ORG Henan I-ORG Province I-ORG No. O NSFRF210314 B-AWARD and O Innovative B-ORG Research I-ORG Team I-ORG of I-ORG Henan I-ORG Polytechnic I-ORG University I-ORG No. O T2022-7 B-AWARD This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81671935 B-AWARD Guangzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Project(Grant O No. O 2018-0402-SF-0686 B-AWARD and O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guang I-ORG Dong I-ORG Province O China O Grant O No. O 2017A040405026 B-AWARD This O research O was O supported O by O the O following O The B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31872262 O 31672363 B-AWARD Coordinated B-ORG Research I-ORG Project I-ORG of I-ORG the I-ORG International I-ORG Atomic I-ORG Energy I-ORG Agency I-ORG 18268 O National B-ORG Key I-ORG Program I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Foundation I-ORG Work I-ORG of I-ORG China I-ORG 2015FY210300 O Science B-ORG and I-ORG Technology I-ORG Major I-ORG Special I-ORG Project I-ORG of I-ORG Guangxi I-ORG GKAA17129002 O Chongqing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG and I-ORG Frontier I-ORG Research I-ORG Planning I-ORG Project I-ORG CSTC2018JCYJA2487 O the O Scientific O and O Technological O Research O Program O of O Chongqing O Municipal O Education O Commission O KJ1600304 O and O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo I-ORG FAPESP O No. O 2016/08551-4 B-AWARD The O authors O greatly O acknowledge O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20220351 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG of I-ORG China I-ORG 20KJB150045 O 22KJB150027 B-AWARD and O Postgraduate B-ORG Research I-ORG I-ORG Practice I-ORG Innovation I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG KYCX22-1277 O The O computational O resources O generously O provided O by O the O High O Performance O Computing O Center O of O Nanjing O Tech O University O are O greatly O appreciated O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21703114 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2016BP03 O Key B-ORG Research I-ORG Project I-ORG of I-ORG Shandong I-ORG Province I-ORG 2018GGX102011 O and O Foundation O of O Qingdao O University O 41117010117 O This O study O was O financially O supported O by O China B-ORG Geological I-ORG Survey I-ORG No. O DD20190475 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 42003035 O the O Youth B-ORG Science I-ORG and I-ORG Technology I-ORG New I-ORG Star I-ORG Project I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 2021KJXX-98 O AK2020-FX01-9 B-AWARD and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 2021JQ-956 O and O 2018JQ3064 B-AWARD and O also O supported O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG China I-ORG University I-ORG of I-ORG Geosciences I-ORG Wuhan O No. O G1323520058 B-AWARD and O CUG170104 B-AWARD This O work O was O supported O by O the O Hainan B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 320QN326 B-AWARD and O the O 2021 B-ORG Guangdong I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Strategy I-ORG Special I-ORG Fund I-ORG No. O 2021A101 B-AWARD and O 2021A05217 B-AWARD and O the O Basic B-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG of I-ORG China I-ORG No. O 2021A1515010538 B-AWARD This O study O was O funded O by O clinical B-ORG research I-ORG special I-ORG fund I-ORG of I-ORG Chinese I-ORG Medical I-ORG Association I-ORG Grant O No. O 18010120741 B-AWARD Basic B-ORG Research I-ORG Program I-ORG of I-ORG Shenzhen I-ORG NO. O JCYJ20160427113153295 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 21807072 B-AWARD Sanming B-ORG Project I-ORG of I-ORG Medicine I-ORG in I-ORG Shenzhen I-ORG SZSM201502035 O and O National B-ORG Key I-ORG Research I-ORG I-ORG Developmental I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC1003904 O It O was O confirmed O the O funding O bodies O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the O Key B-ORG Project I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG QYZDB-SSW-SMC047 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31622012 O and O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2016YFC0503200 O This O research O was O supported O by O Zhejiang B-ORG province I-ORG of I-ORG China I-ORG 2021ZJ004 O the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Zhoushan I-ORG 2020C21020 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41806182 O This O work O was O supported O by O the O following O grants O The B-ORG Strategic I-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Grant O No. O XDB26000000 B-AWARD The B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 41572003 B-AWARD The O Special O Basic O Research O Project O Grant O No: O 2014FY110300 B-AWARD of O MST B-ORG of I-ORG China O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81870854 B-AWARD the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG of I-ORG China I-ORG 19KJA560003 O the O Jiangsu O Specially-Appointed O Professors O Program O the O Priority O Academic O Program O Development O of O Jiangsu O Higher O Education O Institutions O PAPD O in O 2014 O and O the B-ORG Starting I-ORG Foundation I-ORG for I-ORG Talents I-ORG of I-ORG Xuzhou I-ORG Medical I-ORG University I-ORG No. O D2018003 B-AWARD This O research O was O funded O by O an O Innovative O Engineering O for O Health O award O by O the O Wellcome B-ORG Trust I-ORG No. O WT101957 B-AWARD and O the O Engineering B-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG EPSRC O No. O NS/A000027/1 B-AWARD by O a O Starting O Grant O from O the O European B-ORG Research I-ORG Council I-ORG Grant O No. O ERC-2012-StG B-AWARD Proposal O 310970 O MOPHIM O by O an O EPSRC O First O Grant O No. O EP/J010952/1 B-AWARD by O a O Wellcome/EPSRC O Centre O award O 203145Z/16/Z O O NS/A000050/1 B-AWARD by O the O UCL O EPSRC O Centre O for O Doctoral O Training O in O Medical O Imaging O EP/L016478/1 O The O authors O are O grateful O for O financial O support O from O Kyung B-ORG Hee I-ORG University I-ORG in O 2017 O KHU-20171744 O the O Korea B-ORG Health I-ORG Industry I-ORG Development I-ORG Institute I-ORG KHIDI O grant O no. O HI14C3319 B-AWARD National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O grant O no. O NRF-2017M3A9E2058046 B-AWARD O NRF-2016R1A2B4010269 B-AWARD Korea B-ORG Institute I-ORG of I-ORG Industrial I-ORG Technology I-ORG Project O No. O EO170047 B-AWARD and O Basic O Science O Research O Program O through O the O National O Research O Foundation O of O Korea(NRF O funded O by O the O Ministry O of O Education O Science O and O Technology O 2015R1A6A3A04058568 O This O study O was O supported O by O the O Center B-ORG for I-ORG Translational I-ORG Molecular I-ORG Medicine I-ORG CTMM O project O O TRACER B-AWARD VU B-ORG University I-ORG Medical I-ORG Center I-ORG I-ORG Cancer I-ORG Center I-ORG Amsterdam I-ORG CCA—PV13/87 O the O Dutch B-ORG Arthritis I-ORG Association I-ORG NRF O 09-01-404 O and O ZonMw B-ORG translational I-ORG project I-ORG Positron O Emission O Tomography O and O macrophage O targeting O to O select O individuals O at O risk O for O rheumatoid O arthritis O 95104012 B-AWARD This O research O was O supported O by O the O Consortium O for O Advanced O Research O Training O in O Africa O CARTA O CARTA O is O jointly O led O by O the O African O Population O and O Health O Research O Center O and O the O University O of O the O Witwatersrand O and O funded O by O the O Wellcome B-ORG Trust I-ORG UK)(Grant O No: O 087547/Z/08/Z B-AWARD the O Department O for O International O Development O DfID O under O the O Development O Partnerships O in O Higher O Education O DelPHE O the O Carnegie B-ORG Corporation I-ORG of I-ORG New I-ORG York I-ORG Grant O No: O B B-AWARD 8606 O the O Ford B-ORG Foundation I-ORG Grant O No: O 1100-0399),Google.Org B-AWARD Grant O No: O 191994 B-AWARD Sida B-ORG Grant O No: O 54100029 B-AWARD and O MacArthur B-ORG Foundation I-ORG Grant O No: O 10-95915-000-INP B-AWARD The O funders O did O not O in O any O way O contribute O to O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O We O deeply O thank O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31620103912 O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-05 O and O Jiangsu B-ORG Collaborative I-ORG Innovation I-ORG Center I-ORG for I-ORG Modern I-ORG Crop I-ORG Production I-ORG JCIC-MCP O for O their O financial O supports O to O this O research O including O experimental O implementation O sampling O and O data O analysis O The O research O was O funded O by O the O Australian B-ORG Research I-ORG Council I-ORG grant O LP140100680 B-AWARD Brown O Magnus O Barr O Scheurer O and O Bentley O are O researchers O on O the O Australian O Research O Council O Linkage O Grant O LP140100680 O Bentley O is O funded O on O an O Australian B-ORG Research I-ORG Council I-ORG Future I-ORG Fellowship I-ORG FT150100131 O Brown O is O a O researcher O with O the O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG NHMRC O funded O Centre O for O Research O Excellence O CRE O in O Obesity O Policy O and O Food O Systems O grant O no.1041020 O Zapata-Diomedi O is O a O researcher O with O the O NHMRC O CRE O in O Healthy O Liveable O Communities O grant O no. O 1061404 B-AWARD The O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 61807007 B-AWARD National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China O grant O number O 2018YFC2001100 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG China O grant O number O 2242018K40050 B-AWARD 2242019K40042 O funded O this O research O This O study O was O supported O by O the B-ORG Special I-ORG Financial I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Provincial I-ORG No.2015-1297 O Young B-ORG and I-ORG middle-aged I-ORG backbone I-ORG training I-ORG project I-ORG in I-ORG the I-ORG health I-ORG system I-ORG of I-ORG Fujian I-ORG province I-ORG 2016-ZQN-26 O the B-ORG Startup I-ORG Fund I-ORG for I-ORG Scientific I-ORG Research I-ORG Fujian I-ORG Medical I-ORG University I-ORG 2018QH2027 O and O Professor B-ORG Development I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Medical I-ORG University I-ORG No.JS11006 O This O work O was O supported O by O National B-ORG Cancer I-ORG Institute I-ORG R01CA250499 O R37CA222829 B-AWARD and O P01CA093900 B-AWARD Prostate B-ORG Cancer I-ORG Foundation I-ORG 19YOUN12 O and O National B-ORG Institute I-ORG of I-ORG Diabetes I-ORG and I-ORG Digestive I-ORG and I-ORG Kidney I-ORG Diseases I-ORG R01DK125687 O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 32060554 B-AWARD the O Guizhou B-ORG High-level I-ORG Innovative I-ORG Talent I-ORG Training I-ORG Project I-ORG Qianke O Cooperation O Platform O Talent O number O 2016 B-AWARD 5662 O and O the O Guizhou B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Talent I-ORG Team I-ORG of I-ORG Ecological I-ORG Characteristic I-ORG Meat I-ORG Products I-ORG QKHPTRC O 2020 I-AWARD 5004 O This O study O is O supported O by O the O U.S B-ORG National I-ORG Sciences I-ORG Foundation I-ORG grant O AGS-1139479 B-AWARD Z.W O and O J.F O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O Shandong O Joint O Fund O for O Marine O Science O Research O Centers O U1406404 B-AWARD F.Q O and O the O NSFC O grants O 41461164008 B-AWARD and I-AWARD 41130964 I-AWARD Z.M.T O This O work O was O supported O by O grants O from O National B-ORG Administration I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine(2019XZZX-NB007 O 333 B-ORG high I-ORG level I-ORG talents I-ORG training I-ORG project I-ORG in I-ORG Jiangsu I-ORG BRA2016507 O Jiangsu B-ORG Province I-ORG Administration I-ORG of I-ORG Chinese I-ORG Medicine I-ORG ZX2016A2 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Young B-ORG Elite I-ORG Scientists I-ORG Sponsorship I-ORG Programme I-ORG by O CAST O under O Grant O 2017QNRC001 O the O Fujian B-ORG Special I-ORG Fund I-ORG for I-ORG Scientific I-ORG Research I-ORG Institutes I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG under O Grant O 2019R1034-6 O and O 2019R1034-5 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Team I-ORG Programme I-ORG of I-ORG Fujian I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG under O Grant O STIT2017-1–11 O This O work O was O supported O by O grants O from O the O National B-ORG High-tech I-ORG R&D I-ORG Program I-ORG 863 O Program O 2013AA102604 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 31201260 B-AWARD the O Program B-ORG for I-ORG New I-ORG Century I-ORG Excellent I-ORG Talents I-ORG in I-ORG Fujian I-ORG Province I-ORG KLa17073A O and O the O Science B-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG Fujian I-ORG Province[2016NZ0001 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O National O Key O R&D O Program O of O China O under O Grant O 2018YFB1107900 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O 51775091 B-AWARD and O 51575383 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Tianjin I-ORG City I-ORG under O Grant O 18JCQNJC04100 B-AWARD Science O and O Technology O Project O of O Sichuan O Province O under O Grant O 2018GZ0284 O Fundação B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG a I-ORG Tecnologia I-ORG FCT-MCTES O under O Grant O PEst-OE/EME/UI0667/2014 B-AWARD This O work O was O in O part O supported O by O Synthesys O travel O grants O to O F.G O to O visit O Royal B-ORG Museum I-ORG for I-ORG Central I-ORG Africa I-ORG Tervuren O the O Zoological B-ORG Museum I-ORG Copenhagen O the O National B-ORG Museum I-ORG for I-ORG Natural I-ORG History I-ORG in I-ORG Paris O and O the O Natural B-ORG History I-ORG Museum I-ORG of I-ORG Stockholm I-ORG Grants O BE-TAF-1649 B-AWARD DK-TAF-4886 B-AWARD FR-TAF-4104 B-AWARD SE-TAF-3009 B-AWARD respectively O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG Xi’an I-ORG Jiaotong I-ORG University I-ORG xjj2015093 O and O Major B-ORG Basic I-ORG Research I-ORG Project I-ORG of I-ORG Natural I-ORG Science I-ORG of I-ORG Shaanxi I-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG 2017ZDJC-11 O the B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG Shaanxi I-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG 2017ZDXM-SF-068 O and O Shaanxi B-ORG Provincial I-ORG Collaborative I-ORG Technology I-ORG Innovation I-ORG Project I-ORG 2017XT-026 O 2018XT-002 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Japan B-ORG Science I-ORG and I-ORG Technology I-ORG Agency/Japan O International O Cooperation O Agency O Science O and O Technology O Research O Partnership O for O Sustainable O Development O 08080924 B-AWARD JST/JICA O SATREPS O http://www.jst.go.jp/global/english/kadai/h2011_thailand.html O the O Japan B-ORG Agency I-ORG for I-ORG Medical I-ORG Research I-ORG and I-ORG Development O AMED O Grant O No. O 19fk0108101h0501 B-AWARD and O the O Japan B-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG KAKENHI O Grant O No. O 16K19123 B-AWARD 18K07107 B-AWARD and O No. O 18H02654 B-AWARD Natural B-ORG Sciences I-ORG and I-ORG Engineering I-ORG Research I-ORG Council I-ORG of I-ORG Canada I-ORG RGPIN-435784-2013 O RGPIN-2019-07135 B-AWARD to O A.D.S.C O and O a O postdoctoral O fellowship O to O K.D.M O Saskatchewan B-ORG Health I-ORG Research I-ORG Foundation I-ORG establishment O grant O 2867 B-AWARD to O A.D.S.C O United O States O of O America O National B-ORG Science I-ORG Foundation I-ORG award O 1716794 B-AWARD to O D.M.S O Funding O for O open O access O charge O University O of O Regina O research O funds O to O A.D.S.C O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31772083 O Special O fund O for O Technology O Innovation O of O Hubei O Province O 2019AHB07 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC1600100 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2662017JC040 O 2662016QD010 B-AWARD China B-ORG Scholarship I-ORG Council I-ORG 201806765004 O and O the O National O Innovation O and O Entrepreneurship O Training O Program O for O Undergraduates O S201910504071 O 201810504087 O This O research O was O supported O by O the O HSC B-ORG R&D I-ORG division I-ORG STL/5569/19 O and O UKRI B-ORG MRC O MC_PC_20026 O CH O is O supported O by O funding O from O Science B-ORG Foundation I-ORG Ireland I-ORG and I-ORG the I-ORG Department I-ORG for I-ORG the I-ORG Economy I-ORG Northern I-ORG Ireland I-ORG partnership I-ORG award O 15/IA/3152 O This O work O was O supported O by O theNational O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China(No O 51574159 B-AWARD 51704152),Shandong B-AWARD Province I-ORG Natural I-ORG Science I-ORG Foundation(No O ZR2014EEM001 B-AWARD ZR2017BEE001),Shandong B-AWARD Natural I-ORG Science I-ORG Outstanding I-ORG Youth I-ORG Foundation(No O JQ201612 B-AWARD This O work O is O financially O supported O by O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of O China O No. O LY22E020013 B-AWARD the O Zhejiang B-ORG Public I-ORG Welfare I-ORG Technology I-ORG Application I-ORG Research I-ORG Project I-ORG No. O LGC20E010003 B-AWARD and O the O Foundation B-ORG of I-ORG Zhejiang I-ORG Educational I-ORG Committee I-ORG No. O Y201738304 B-AWARD This O work O was O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFE0206600 O to O Y.B O International B-ORG Partnership I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG 153F11KYSB20160008 O to O Y.X O The B-ORG 13th I-ORG Five-year I-ORG Informatization I-ORG Plan I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XXH13505-05 O to O Y.B O The O 100-Talent O Program O of O Chinese O Academy O of O Sciences O to O Y.B O and O Z.Z O The O Open O Biodiversity O and O Health O Big O Data O Initiative O of O IUBS O to O Y.B O The O funding O bodies O had O no O role O in O the O design O of O the O study O collection O analysis O interpretation O of O data O nor O the O writing O of O the O manuscript O This O research O was O supported O by O three O sources O of O funding O and O Zhengyang O Zhao O received O the O funding O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31471845,http://www.nsfc.gov.cn B-AWARD the B-ORG Earmarked I-ORG Fund I-ORG for I-ORG Modern I-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG of I-ORG China I-ORG No. O CARS-28,http://119.253.58.231 B-AWARD and O National B-ORG Sci-Tech I-ORG Support I-ORG Plan I-ORG No. O 2014BAD16B06,http://program.most.gov.cn B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O grants O from O the B-ORG National I-ORG “973” I-ORG Key I-ORG Basic I-ORG Research I-ORG Development I-ORG Program I-ORG 2012CB316501 O and I-AWARD 2013CB910801 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31171268 O the B-ORG Program I-ORG of I-ORG International I-ORG S&T I-ORG Cooperation I-ORG 2014DFB30020 O and O the B-ORG Fundamental I-ORG Research I-ORG Program I-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Commission I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 14DZ1951300 O and I-AWARD 14DZ2252000 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31972802 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2019MC041 O National O Key O R&D O Program O of O China O 2018YFD0900400 O Taishan O Scholar O Program O of O Shandong O Province O tsqn201812023 O This O research O was O funded O by O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 41876149 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG Grant O No. O ZR2017MC046 B-AWARD and O ZR2019MD018 B-AWARD and O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG of I-ORG Shandong I-ORG Province I-ORG Grant O No. O 2018GHY115021 B-AWARD This O work O was O supported O by O the O Hong B-ORG Kong I-ORG Research I-ORG Grant I-ORG Council I-ORG NSFC/RGC I-ORG Joint I-ORG Research I-ORG Scheme I-ORG N_CUHK401/21 O Collaborative B-ORG Research I-ORG Fund I-ORG C4015-20EF O and O The O Chinese B-ORG University I-ORG of I-ORG Hong I-ORG Kong I-ORG Direct O Grant O 4053433 O 4053489 B-AWARD MFFA O was O supported O by O the O Ph.D O studentship O of O The O Chinese O University O of O Hong O Kong O This O work O was O supported O by O the O National B-ORG Health I-ORG Research I-ORG Institutes I-ORG Miaoli I-ORG Taiwan I-ORG http://english.nhri.org.tw/NHRI_WEB/nhriw001Action.do O Career O Development O Grant O NHRI-EX103-10316NC B-AWARD to O H.-S.H O the O National B-ORG Taiwan I-ORG University I-ORG Taipei I-ORG Taiwan I-ORG http://www.ntu.edu.tw/english/)(AIM O for O Top O University O Excellent O Research O Project O 102C101-42 B-AWARD 103C101-C1 I-AWARD 104C101-B1 I-AWARD 105R3701 I-AWARD to O S.S.G O and O H.-S.H O the O National B-ORG Taiwan I-ORG University I-ORG Hospital I-ORG http://www.ntuh.gov.tw/en/default_P.aspx O NTHU-UN104-018 O NTUH-UN105-014 I-AWARD to O S.S.G O and O H.-S.H O and O the O Foundation B-ORG for I-ORG the I-ORG Advancement I-ORG of I-ORG Outstanding I-ORG Scholarship I-ORG Taipei I-ORG Taiwan I-ORG http://www.faos.org.tw/English/aboutus.html O Young O Scholars’ I-AWARD Creativity I-AWARD Award O to O H.-S.H O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Taipei I-ORG Taiwan I-ORG https://www.most.gov.tw/en/public O General O Research O Project O MOST B-AWARD 105-2628-B-002-033-MY3 I-AWARD to O H.-S.H O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2019YFA0905700 O the O “Major B-ORG Project” I-ORG of I-ORG Haihe I-ORG Laboratory I-ORG of I-ORG Synthetic I-ORG Biology I-ORG 22HHSWSS00001 O and O the O Tianjin B-ORG Synthetic I-ORG Biotechnology I-ORG Innovation I-ORG Capacity I-ORG Improvement I-ORG Project I-ORG TSBICIP-PTJS-003 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O 81602366 O 81402258 I-AWARD 81570884 O the O Scientific B-ORG Research I-ORG Program I-ORG of I-ORG National I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG China I-ORG 201402014 O the B-ORG ShuGuang I-ORG Project I-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Education I-ORG Commission I-ORG and I-ORG Shanghai I-ORG Education I-ORG Development I-ORG Foundation I-ORG 14SG18 O and O the B-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG 17DZ2260100 O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangdong I-ORG 2015B020233009 O 2015A030401040 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG funded O project O 2016M602486 O National B-ORG Science I-ORG Foundation I-ORG for I-ORG Young I-ORG Scientists I-ORG of I-ORG China I-ORG 81802435 O Fundamental O Research O Funds O for O the O Central O Universities O Nankai B-ORG University I-ORG 035-63161138 O 035-63191141 B-AWARD 035-63191735 B-AWARD to O Z.Y O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31670763 O to O Z.Y O 81101266 B-AWARD to O J.C O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Tianjin I-ORG of O China O 15JCZDJC65400 O to O Z.Y O Funding O for O open O access O charge O National O Natural O Science O Foundation O of O China O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 52075158 O 52205355 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG 2021JJ30109 O and O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Materials I-ORG Processing I-ORG and I-ORG Die I-ORG I-ORG Mould I-ORG Technology I-ORG Huazhong I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG P2023-016 O This O work O was O supported O by O the O Discipline B-ORG Talent I-ORG Promotion I-ORG Program I-ORG of I-ORG “Xinglin I-ORG Scholars” I-ORG No.QNXZ2018005 O Miaozi B-ORG Cultivation I-ORG Project I-ORG of I-ORG Sichuan I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG No. O 2018137 B-AWARD the O Key B-ORG Fund I-ORG Project I-ORG for I-ORG Education I-ORG Department I-ORG of I-ORG Sichuan I-ORG No. O 18ZA0181 B-AWARD Education B-ORG Department I-ORG of I-ORG Sichuan I-ORG Province I-ORG No. O 17ZB0156 B-AWARD and O Department B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Sichuan I-ORG Province I-ORG No. O 2016SZYZF0002 B-AWARD This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC81400236 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG 2016J01153 O 2017J01816 I-AWARD 2017J01528 I-AWARD and I-AWARD 2017J05134 O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Joint I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG 2016Y9038 O and O the B-ORG Project I-ORG of I-ORG Education I-ORG Department I-ORG of I-ORG Fujian I-ORG Province I-ORG JA15212 O This O research O was O funded O by O Financial O support O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61601227 B-AWARD 31971740 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017M621598 O Nature O Science O Foundation O of O Jiangsu O Province O BK20160939 O Key O University O Science O Research O Project O of O Jiangsu O Province O 17KJA220004 O Jiangsu B-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Independent I-ORG Innovation I-ORG Project I-ORG CX(18)3033 O Science O and O Technology O Program O of O Fujian O Province O 2019N3014 O This O study O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0101004 O and I-AWARD 2017YFD0100900 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31771794 O the O outstanding B-ORG Youth I-ORG Foundation I-ORG of I-ORG the I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2016JQ0040 O the O Key B-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG the I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2016NZ0057 O and O the O International B-ORG Science I-ORG I-ORG Technology I-ORG Cooperation I-ORG Program I-ORG of I-ORG the I-ORG Bureau I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Chengdu I-ORG China I-ORG No. O 2015DFA306002015-GH0300008-HZ O The O funding O bodies O had O no O role O but O provided O the O financial O support O to O this O research O including O in O the O experimental O design O data O collection O and O analysis O and O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32288101 O 32200536 B-AWARD and O 31521003 B-AWARD the O Shanghai B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG 2017SHZDZX01 O the O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG 2019-I2M-5-066 O the O Major B-ORG Project I-ORG of I-ORG Special I-ORG Development I-ORG Funds I-ORG of I-ORG Zhangjiang I-ORG National I-ORG Independent I-ORG Innovation I-ORG Demonstration I-ORG Zone I-ORG ZJ2019-ZD-004 O the O Shanghai B-ORG Sailing I-ORG Program I-ORG 23YF1430500 O and O the O 111 B-ORG Project I-ORG B13016 O German B-ORG Science I-ORG Foundation I-ORG CRC992 O ‘Medical O Epigenetics’ O to O L.R O T.M O R.B O B.G O GI B-AWARD 747/2-1 O GI B-AWARD 747/3-1 I-AWARD to O R.G O German O Federal B-ORG Ministry I-ORG of I-ORG Education I-ORG and I-ORG Research I-ORG 031 O A538A I-AWARD de.NBI-RBC O awarded O to O R.B O German O Federal O Ministry O of O Education O and O Research O 031 O L0101C I-AWARD de.NBI-epi O awarded O to O B.G O R.B O was O supported O by O the O German B-ORG Research I-ORG Foundation I-ORG DFG O under O Germany’s O Excellence O Strategy O CIBSS-EXC-2189-Project O ID O 390939984 B-AWARD Funding O for O open O access O charge O German O Federal O Ministry O of O Education O and O Research O This O work O was O supported O by O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grants O No.LY15H290004 O and O No.LY16H290002 O National B-ORG TCM I-ORG Clinical I-ORG Research I-ORG Bases I-ORG of I-ORG China I-ORG under O Grant O No.JDZX2015116 O and O Health B-ORG Commission I-ORG of I-ORG Zhejiang I-ORG Province I-ORG under O Grant O No.2015ZDA021 O The O funding O body O provided O financial O support O and O had O no O role O in O the O design O of O the O study O collection O analysis O interpretation O of O data O or O writing O the O manuscript O This O publication O forms O part O of O several O projects O funded O by O the B-ORG Spanish I-ORG government O MCIN/AEI/10.13039/501100011033 O grant O RYC2019-028370-I B-AWARD and O AEI O PID2021-127516NB-I00 B-AWARD the B-ORG Valencian I-ORG Community O CIAICO/2021/088 B-AWARD and O the B-ORG University I-ORG Jaume I-ORG I: O UJI-B2022-55 B-AWARD The O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32272051 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG LZ22C130003 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG China I-ORG the I-ORG International I-ORG Cooperation I-ORG Project I-ORG 2018YFE0111900 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Provincial I-ORG Universities I-ORG of I-ORG Zhejiang I-ORG 2022YW79 O This O research O was O funded O by O the O Fuxi B-ORG Talents I-ORG Project I-ORG of I-ORG Gansu I-ORG Agricultural I-ORG University O grant O number O Gaufx-02Y05 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 32260899 B-AWARD 31602102 B-AWARD Gansu B-ORG University I-ORG Industry I-ORG Support I-ORG Project O grant O number O 2020C-14 B-AWARD The B-ORG Youth I-ORG Tutor I-ORG Fund I-ORG of I-ORG Gansu I-ORG Agricultural I-ORG University O grant O number O GAU-QDFC-2021-04 B-AWARD Technical B-ORG Entrusted I-ORG Project O grant O number O GSAU-JSYF-2021-021 B-AWARD The O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81502813 O by O Major B-ORG scientific I-ORG research I-ORG project I-ORG of I-ORG Wuxi I-ORG Municipal I-ORG Health I-ORG Commission I-ORG Z201902 O by O Maternal B-ORG and I-ORG Child I-ORG Health I-ORG Research I-ORG Key I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG F201601 O by O Jiangsu B-ORG Maternal I-ORG and I-ORG Child I-ORG Health I-ORG Youth I-ORG Talents I-ORG Project I-ORG FRC201783 O by O Wuxi B-ORG Kejiao I-ORG Qiang I-ORG Wei I-ORG Key I-ORG Medical I-ORG Talent I-ORG Project I-ORG ZDRC010 O by O Wuxi B-ORG Health I-ORG Planning I-ORG Commission I-ORG of I-ORG Maternal I-ORG and I-ORG child I-ORG health I-ORG Appropriate I-ORG Technical I-ORG Projects I-ORG Fund I-ORG FYTG201736 O The O funding O institution O had O no O role O in O the O design O data O collection O analysis O interpretation O and O writing O of O the O manuscript O This O work O was O supported O by O internal O grants O from O the O Office O of O Academic O Research O Qatar B-ORG University O Doha O Qatar O under O Grants O # O QUUG-CPH-15/16–7 B-AWARD and O QUUG-CPH-2017–5 B-AWARD The O publication O of O this O article O was O funded O by O the O Qatar O National O Library O Doha O Qatar O The O experiments O dealing O with O the O testing O of O the O compoundsin O vitrowere O supported O by O the B-ORG National I-ORG Institutes I-ORG on I-ORG Alcohol I-ORG Abuse I-ORG and I-ORG Alcoholism I-ORG under O Grant O Number O R01AA019458 B-AWARD Y.S O We O are O grateful O to O Professor O Neal O Castagnoli O Jr. O Professor O Emeritus O Virginia O Tech O for O providing O the O MMTP O substrate O The O biological O section O of O this O study O was O funded O in O part O by O the B-ORG National I-ORG Research I-ORG Foundation I-ORG of I-ORG South I-ORG Africa I-ORG under O Grant O number O UID O 85642 B-AWARD 96180 B-AWARD This O study O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0501302 O 2016YFD0500707 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 31520103916 I-AWARD 31402185 I-AWARD 81201302 O and O Postdoctoral B-ORG Science I-ORG Foundation I-ORG in I-ORG China I-ORG 2015T80310 O 2012M520683 O S.O O is O supported O by O a O Grant-in-Aid O for O Scientific O Research O grant O number O 22H03470 B-AWARD from O the O Japanese B-ORG Ministry I-ORG of I-ORG Education I-ORG Culture I-ORG Sports I-ORG Science I-ORG and I-ORG Technology O E.I O is O supported O by O a O Grant-in-Aid O for O Scientific O Research O grant O number O 20K11186 B-AWARD from O the O Japanese O Ministry O of O Education O Culture O Sports O Science O and O Technology O J.P.F O is O supported O by O the O Auckland B-ORG Medical I-ORG Research I-ORG Foundation I-ORG grant O number O 1119008 B-AWARD the O Health B-ORG Research I-ORG Council I-ORG of I-ORG New I-ORG Zealand I-ORG grant O number O 19/687 B-AWARD and O the O Royal B-ORG Society I-ORG Te I-ORG Apārangi I-ORG grant O number O 19-UOA-170 B-AWARD This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 32002186 B-AWARD National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2021YFD1300400 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG Grant O No. O 2020A1515010322 B-AWARD and O Guangzhou B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG Grant O No. O 202102020850 B-AWARD This O work O was O supported O by O grants O from O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG in I-ORG Taiwan I-ORG MOST O 103-2314-B-075 B-AWARD 078 I-AWARD MY2 O Taipei B-ORG Veterans I-ORG General I-ORG Hospital I-ORG V104B-001 O and I-AWARD V105B-001 O and O Szu-Yuan B-ORG Research I-ORG Foundation I-ORG of I-ORG Internal I-ORG Medicine I-ORG 105001 O Funding O was O provided O by O the O United B-ORG States I-ORG National I-ORG Academy I-ORG of I-ORG Sciences I-ORG and I-ORG the I-ORG United I-ORG States I-ORG Agency I-ORG for I-ORG International I-ORG Development I-ORG through O the O Partnership O for O Enhanced O in O Research O http://sites.nationalacademis.org/pga/peer/index.htm O award O number O AID-OAA-A11-00012 B-AWARD to O Darren O Norris O James O P. O Gibbs O and O Fernanda O Michalski O Fernanda O Michalski O received O a O productivity O scholarship O from O the O Brazilian B-ORG National I-ORG Council I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Development I-ORG CNPq O O process O 301562/2015-6 B-AWARD and I-AWARD 302806/2018-0 O and O is O funded O by O CNPq O Process O 403679/2016-8 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O grants O from O New B-ORG York I-ORG Sea I-ORG Grant I-ORG to O Bassem O Allam O and O Emmanuelle O Pales O Espinosa O Projects O R/XG-24 B-AWARD and O R/XG-33 B-AWARD Partial O support O was O also O provided O by O the O National B-ORG Science I-ORG Foundation I-ORG IOS O 1656753 O and O the O Atlantic B-ORG States I-ORG Marine I-ORG Fisheries I-ORG Commission I-ORG Contract O 19-0802 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Fund I-ORG of I-ORG China I-ORG grant O no. O 62275266 B-AWARD the O Major B-ORG Scientific I-ORG and I-ORG Technological I-ORG Projects I-ORG in I-ORG Shaanxi I-ORG Province I-ORG grant O no. O 2018zdzx01-03-01 B-AWARD and O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shaanxi I-ORG Province I-ORG grant O nos O 2020ZDLGY01-06 B-AWARD and O 2019ZDLGY02-07 B-AWARD This O work O was O supported O by O the O National B-ORG Social I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O “Research O on O the O Digital-Intelligence O Transformation O Mechanism O and O Path O of O the O New O Generation O of O Information O Technology-Driven O Financial O Shared O Services” O project O number O 21BGL040 B-AWARD the O Soft B-ORG Science I-ORG Research I-ORG Project I-ORG of I-ORG Henan I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG Research O on O Information O System O Framework O Based O on O Budget O Performance O Management O project O number O 202400410419 B-AWARD and O the O Philosophy B-ORG and I-ORG Social I-ORG Science I-ORG Planning I-ORG of I-ORG Henan I-ORG Province I-ORG Research O on O the O dynamic O mechanism O and O path O of O Henan’s O new O urbanization O development O under O the O background O of O “three O new O and O one O high” O project O number O 2022BJJ119 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 82070661 B-AWARD W.B.Z O 81970560 B-AWARD Z.L O and O 82120108006 B-AWARD Z.L. O the B-ORG Scientific I-ORG Innovation I-ORG Program I-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Education I-ORG Committee I-ORG No. O 201901070007E00052 B-AWARD and O the B-ORG “Clinical I-ORG Technology I-ORG Innovation I-ORG Project I-ORG Task I-ORG Contract)” I-ORG of I-ORG Shanghai I-ORG Shenkang I-ORG Hospital I-ORG Development I-ORG Center I-ORG No. O SHDC2020CR2032B B-AWARD This O study O was O supported O by O the O Special O Program O for O New B-ORG Transgenic I-ORG Variety I-ORG Breeding I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG China I-ORG 2016ZX08012005 O 2012ZX08011002 B-AWARD the O National B-ORG Nature I-ORG Science I-ORG Foundations I-ORG of I-ORG China I-ORG NSFC O 31871963 O 31272051 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG KYZ201818 O and O the O Qing-Lan O Project O of O Jiangsu O Province O of O China O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O is O supported O by O the O National B-ORG Institutes I-ORG of I-ORG Health O National O Center O for O Advancing O Translational O Sciences O Clinical O and O Translational O Science O Award O UL1TR002529 O to O S.Libring O the O National B-ORG Cancer I-ORG Institute I-ORG R00CA198929 O to O L.Solorio O the O American B-ORG Cancer I-ORG Society I-ORG RSG-16-172-01 O to O M. O Wendt O and O the O National O Institutes O of O Health O DP2 O AT009833 I-AWARD to O S. O Calve O Our O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81902953 B-AWARD 30973501 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province I-ORG grant O number O 20180530068 B-AWARD the B-ORG City I-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG Shenyang I-ORG grant O number O 17231178 B-AWARD the B-ORG Outstanding I-ORG Scientific I-ORG Fund I-ORG of I-ORG Shengjing I-ORG Hospital I-ORG grant O number O M731 B-AWARD Liaoning B-ORG BaiQianWan I-ORG Talents I-ORG Program I-ORG grant O number O 3200417003 B-AWARD 345 O Talent O Project O of O Shengjing O Hospital O of O China O Medical O University O UK B-ORG Research I-ORG and I-ORG Innovation O Grant/Award O Number O MR/S017968/1 B-AWARD Norges B-ORG Forskningsråd O Grant/Award O Number O 273674 B-AWARD Medical B-ORG Research I-ORG Council O Grant/Award O Number O MC_UU_00002/10 B-AWARD This O research O was O supported O in O part O by O the O National O Research O Foundation O of O Korea O NRF O grant O funded O by O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG ICT I-ORG Grant O No. O 2018R1A5A2025286 B-AWARD 2021R1A2C2005820 B-AWARD and O 2021M3A9E4021818 B-AWARD the O Research O Supporting O Program O of O the O Korean B-ORG Association I-ORG for I-ORG the I-ORG Study I-ORG of I-ORG the I-ORG Liver I-ORG Grant O No. O KASL2018-01 B-AWARD and O the O Technology B-ORG Innovation I-ORG Program I-ORG or O Industrial O Strategic O Technology O Development O Program-Bioindustry O Strategic O Technology O Development O Program O Grant O No. O 20013712 B-AWARD funded O by O the O Ministry O of O Trade O Industry O O Energy O MOTIE O Korea O The O funding O sources O had O no O role O in O the O design O of O this O study O and O did O not O have O any O role O during O its O execution O analyses O interpretation O of O the O data O or O decision O to O submit O results O The B-ORG research I-ORG was I-ORG partially I-ORG supported I-ORG by I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51622507 B-AWARD 61471255,61474079 B-AWARD 61501316 B-AWARD 51505324 B-AWARD Doctoral B-ORG Fund I-ORG of I-ORG MOE I-ORG of I-ORG China I-ORG No. O 20131402110013 B-AWARD 863 B-ORG project I-ORG 2015AA042601 O Excellent B-ORG Talents I-ORG Technology I-ORG Innovation I-ORG Program I-ORG of I-ORG Shanxi I-ORG Province I-ORG of I-ORG China(201805D211020 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81672515 O Shanghai B-ORG Pujiang I-ORG Program I-ORG 16PJD039 O and O Shanghai B-ORG Municipal I-ORG Education I-ORG Commission—Gaofeng I-ORG Clinical I-ORG Medicine I-ORG Grant I-ORG 20172019 O This O research O was O funded O by O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Innovation I-ORG MCIN/AEI/10.13039/501100011033 B-AWARD and O “ERDF O A O way O of O Making O Europe” O PID2021-127296OB-I00 O to O A.V.C O projects O were O funded O by O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III I-ORG and O co-funded O by O European B-ORG Union I-ORG ESF O “Investing O in O your O future”):“PI18/00349 O and O PI21/00394 B-AWARD FIS O project O to O O.A.)” O “FI19/00146 O PFIS O contract O for O S.H.-D.)” O Protein O Targets O and O Bioactive O Compounds O Group O E45_17R O to O A.V.-C O and O Digestive O Pathology O Group O B25_17R O to O S.H.-D O O.A O Á.L O P.R O and O M.J.D.-A O and O the O Centro B-ORG de I-ORG Investigación I-ORG Biomédica I-ORG en I-ORG Red I-ORG en I-ORG Enfermedades I-ORG Hepáticas I-ORG y I-ORG Digestivas I-ORG CIBERehd O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 31371664 B-AWARD to O WW O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O no. O 2017YFD0100705 B-AWARD to O ZR) O and O the O Key B-ORG Project I-ORG of I-ORG Henan I-ORG Natural I-ORG Science I-ORG Foundation I-ORG grant O no. O 182300410002 B-AWARD to O WW O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the O Ministry B-ORG of I-ORG Science I-ORG Technology I-ORG and I-ORG Innovation I-ORG 02-01-02-SF1052 O Universiti B-ORG Kebangsaan I-ORG Malaysia I-ORG DPP-2015-033 O GUP-2014-009 B-AWARD and O the O Ministry B-ORG of I-ORG Higher I-ORG Education I-ORG FRGS/1/2015/SG05/UKM/02/2 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O work O of O OL O was O supported O by O a O Maria O Barbeito O research O contract O from O Xunta B-ORG de I-ORG Galicia O KK O was O recruited O from O the O European B-ORG Union I-ORG Seventh I-ORG Framework I-ORG Programme I-ORG FP7/2007-2013 O under O grant O agreement O n° O 324439 B-AWARD The O research O leading O to O these O results O has O received O funding O from O project O grants O 10MDS373027PR B-AWARD Xunta O de O Galicia O and O GA O 324439 O FP7/2007-2013 O General O support O to O the O group O EXPRELA O was O funded O by O Xunta O de O Galicia O Consolidación O D.O.G O 10-10-2012 O Contract O Number O 2012/118 B-AWARD co-financed O by O FEDER B-ORG This O trial O was O financially O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81273985 O No.81473523 O and O No.81603492 O Doctoral B-ORG Fund I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG No.20125132110011 O Primary B-ORG Funding I-ORG Source I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG the I-ORG People's I-ORG Republic I-ORG of I-ORG China I-ORG through I-ORG the I-ORG Twelfth I-ORG Five-Year I-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG Pillar I-ORG Program(No O 2015BAI04B00 B-AWARD The O funding O agent O plays O no O role O in O study O design O data O collection O data O analyses O data O interpretation O or O writing O of O the O report O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81960273 O 81960279 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Gansu I-ORG Province I-ORG 21JR5RA905 O 21JR5RA928 B-AWARD the O Health B-ORG Industry I-ORG Scientific I-ORG Research I-ORG Program I-ORG of I-ORG Gansu I-ORG Province I-ORG GSWSKY2021-012 O the O Talent B-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Project I-ORG of I-ORG Lanzhou I-ORG City I-ORG 2022-RC-47 O and O the O Medical B-ORG Research I-ORG Innovation I-ORG Ability I-ORG Promotion I-ORG Project I-ORG of I-ORG Lanzhou I-ORG University I-ORG lzuyxcx-2022-191 O This O work O was O supported O by O the B-ORG Special I-ORG Subsidy I-ORG for I-ORG Central I-ORG Guidance I-ORG of I-ORG China I-ORG 2017070503B041 O granted O to O SLH O Anhui B-ORG Provincial I-ORG science I-ORG and I-ORG technology I-ORG key I-ORG projects I-ORG 1501041142 O granted O to O SLH O Anhui B-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Tumor I-ORG Immunotherapy I-ORG and I-ORG Nutrition I-ORG Therapy I-ORG 1606c08236 O granted O to O SLH O and O the B-ORG Key I-ORG research I-ORG and I-ORG development I-ORG plan I-ORG of I-ORG Anhui I-ORG Province I-ORG 1704a0802148 O granted O to O YYP O The O current O study O was O supported O by O grants O from O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC1310400 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81371465 O and O 81671324 B-AWARD and O the O Research B-ORG Foundation I-ORG of I-ORG Education I-ORG Bureau I-ORG of I-ORG Hunan I-ORG Province I-ORG 17C0122 O The O sponsors O had O no O role O in O the O study O design O survey O process O data O analysis O and O manuscript O preparation O This O project O was O supported O by O The O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81502468 B-AWARD Provincial-ministerial B-ORG Co-construction I-ORG Project I-ORG of I-ORG Henan I-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Key I-ORG Point I-ORG Tackling I-ORG Plan I-ORG SB201901114 O and O Henan B-ORG Provincial I-ORG Scientific I-ORG and I-ORG Technological I-ORG Project I-ORG 162102310046 O 182102310387 B-AWARD This O project O was O funded O by O National B-ORG Institute I-ORG of I-ORG Diabetes I-ORG and I-ORG Digestive I-ORG and I-ORG Kidney I-ORG Diseases I-ORG NIH O R01 O DK110793 B-AWARD and O the O Gerber B-ORG Foundation I-ORG 15PN-013 O PKB O receives O funding O from O Eunice B-ORG Kennedy I-ORG Shriver I-ORG National I-ORG Institute I-ORG of I-ORG Child I-ORG Health I-ORG I-ORG Human I-ORG Development I-ORG NIH O K99 B-AWARD HD098288 O TLA O receives O funding O from O National B-ORG Institute I-ORG of I-ORG Environmental I-ORG Health I-ORG Sciences I-ORG NIH O R00 B-AWARD ES027853 O SNI O and O DAR O receives O funding O from O the O Russian O Science O Foundation O Grant O 19-14-00305 O The O project O was O supported O by O Zhejiang B-ORG Provincial I-ORG Medical I-ORG and I-ORG Health I-ORG Planning I-ORG Project I-ORG No.2023KY898 O Zhejiang B-ORG Provincial I-ORG Research I-ORG Centre I-ORG for I-ORG Diagnosis I-ORG and I-ORG Treatment I-ORG of I-ORG Critical I-ORG Liver I-ORG and I-ORG Biliary I-ORG Diseases I-ORG Minimally O Invasive O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG LY19H030006 O Zhejiang B-ORG Medical I-ORG Association I-ORG Foundation I-ORG 2009ZYC15 O and O Wenzhou B-ORG Science I-ORG and I-ORG technology I-ORG program I-ORG 2021Y1413 O This O research O was O funded O by O the O Department B-ORG of I-ORG State I-ORG Health I-ORG Services O contract O HHS000961900001 O to O L.R.R O funded O via O the O Centers O for O Disease O Control O and O Prevention O National O and O State O Tobacco O Control O Program O grant O NU58DP006805 B-AWARD on O which O I.M.L O A.R O M.B O T.A.C O B.K O and O T.W O were O supported O Additionally O work O on O the O manuscript O and O its O revisions O were O supported O by O the O National B-ORG Institute I-ORG on I-ORG Drug I-ORG Abuse I-ORG NIDA I-ORG of I-ORG the I-ORG National I-ORG Institutes I-ORG of I-ORG Health I-ORG NIH O award O R25DA054015 B-AWARD to O L.R.R O as O MPI O on O which O M.B O was O a O scholar O and O on O which O T.A.C O and O A.R O were O supported O as O well O as O by O the O NIDA B-ORG through I-ORG the I-ORG National I-ORG Institute I-ORG on I-ORG Minority I-ORG Health I-ORG and I-ORG Health I-ORG Disparities I-ORG of I-ORG the I-ORG NIH O award O 3U54MD015946-03S1 B-AWARD to O Ezemenari O Obasi O on O which O M.B O and O I.M.L O are O MPIs O of O the O science O and O on O which O L.R.R O was O supported O The O work O was O supported O by O the O 863 B-ORG project I-ORG 2013AA102501 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31201797 O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG ASTIP-IAS04 O ASTIP-IAS-TS-15 B-AWARD and O National B-ORG Nonprofit I-ORG Institute I-ORG Research I-ORG Grant I-ORG 2017ywf-zd-2 O This O study O was O supported O by O LiaoNing B-ORG Revitalization I-ORG Talents I-ORG Program I-ORG XLYC1807131 O the B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Foundation I-ORG of I-ORG Dalian I-ORG 2020JJ27SN070 O and O Teaching B-ORG reform I-ORG research I-ORG project I-ORG of I-ORG Dalian I-ORG Medical I-ORG University I-ORG DYLX19010 O The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG LY18E030002 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Ningbo I-ORG 2018A610111 O Key B-ORG Laboratory I-ORG of I-ORG Marine I-ORG Materials I-ORG and I-ORG Related I-ORG Technologies I-ORG 2016K07 O and O K.C O Wong O Magna O Fund O in O Ningbo O University O This O work O was O supported O with O three O grants O under O the O direction O of O Verónica O Williner O Universidad B-ORG Nacional I-ORG del I-ORG Litoral I-ORG CAI+D O PI I-AWARD 119 O CONICET B-ORG PIP O 052 I-AWARD 2011-2013 O FONCYT B-ORG PICT O Bicentenario I-AWARD 059 I-AWARD 2010–2011 O and O the O grants O MinCyT-CAPES B-ORG BR11/14 B-AWARD and O CAPES-MinCyT B-ORG 206/12 B-AWARD under O the O direction O of O Pablo O Collins O and O Célio O Magalhães O Célio O Magalhães O received O a O Research O Fellowship O Proc O 303.837/2012-8 O from O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico,—CNPq O Renata B-ORG Lima-Gomes I-ORG recieved I-ORG a I-ORG Doctoral I-ORG Grant I-ORG Proc O 140191/2014-3 O from O CNPq O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O American B-ORG Heart I-ORG Association I-ORG Scientist I-ORG Development I-ORG Grant O 10SDG2570037 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O 81172050 O 81570263 B-AWARD and O Grant B-ORG of I-ORG Sichuan I-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Agency I-ORG Grant O 2014FZ0104 O to O J. O Wu. O This O work O was O supported O by O the O Minerva B-ORG Foundation I-ORG 13082018 O National B-ORG Science I-ORG Foundation I-ORG 1636752 O the B-ORG Ministry I-ORG of I-ORG Higher I-ORG Education I-ORG Libyan I-ORG government I-ORG Number O 799 O Suomen B-ORG Hammaslääkäriseura I-ORG Apollonia I-ORG 07032016 O This O study O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2015A030313217 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC)-Guangdong I-ORG Joint I-ORG Foundation I-ORG Key I-ORG Project I-ORG No. O U1501214 B-AWARD and O the B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2013B010404005 B-AWARD This O study O was O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2022A1515012552 O Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Committee I-ORG SZSTI O JCYJ20220818102611025 O and O Research B-ORG Initiation I-ORG Project I-ORG of I-ORG Shunde I-ORG Hospital I-ORG Southern I-ORG Medical I-ORG University I-ORG CRSP2022002 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Fund I-ORG of I-ORG China I-ORG 31501734 O China B-ORG Litchi I-ORG and I-ORG Longan I-ORG Industry I-ORG Technology I-ORG Research I-ORG System I-ORG CARS-32-05 O the O Key B-ORG Areas I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2018B020202011 O and O YangFan B-ORG Innovative I-ORG I-ORG Entrepreneurial I-ORG Research I-ORG Team I-ORG Project I-ORG 2014YT02H013 O The O funders O had O no O role O in O study O design O data O collection O analysis O and O interpretation O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDB22040402 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 11525211 O 11472263 B-AWARD 11572307 B-AWARD 11772319 B-AWARD the O CNPC-CAS B-ORG Strategic I-ORG Cooperation I-ORG Research I-ORG Program I-ORG 2015A-4812 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG WK2090050040 O the O Young B-ORG Elite I-ORG Scientists I-ORG Sponsorship I-ORG Program I-ORG by I-ORG CAST I-ORG 2016QNRC001 O the O National B-ORG Postdoctoral I-ORG Program I-ORG for I-ORG Innovative I-ORG Talents I-ORG BX201700225 O the O Anhui O Provincial O Natural O Science O Foundation O 1808085QA07 O and O the O China O Postdoctoral O Science O Foundation O 2017M620264 O The O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG No. O 2015CB553605 B-AWARD supported O the O study O in O study O design O The O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFC1305500 B-AWARD 2016YFC1305503 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81601211 B-AWARD No. O 8160050078 B-AWARD supported O the O study O in O the O examinations O and O data O collection O The O Science B-ORG I-ORG Technology I-ORG Project I-ORG of I-ORG Beijing I-ORG No. O D171100002817002 B-AWARD and O the O Beijing B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG No. O Z181100001918015 B-AWARD supported O the O study O in O data O analysis O and O interpretation O The O Science B-ORG and I-ORG Technology I-ORG Development I-ORG Plan I-ORG Project I-ORG of I-ORG Jilin I-ORG Province I-ORG No. O 20180520126JH B-AWARD supported O the O study O in O writing O the O manuscript O This O work O was O supported O by O the O Geological B-ORG Society I-ORG of I-ORG London I-ORG William I-ORG George I-ORG Fearnsides I-ORG Fund I-ORG and I-ORG by I-ORG NERC I-ORG Standard I-ORG Grant I-ORG NE/I027630/1 B-AWARD awarded O to O Michael O J O Benton O It O was O also O supported O by O the O Newton B-ORG Advanced I-ORG Fellowships I-ORG of I-ORG the I-ORG Royal I-ORG Society I-ORG NA160290 O and O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDB26000000 O XDB183030504 O awarded O to O Qi O Zhao O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of O China O No. O 31601406 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG of O China O No. O ZR2016CB30 B-AWARD the O Applied B-ORG Basic I-ORG Research I-ORG Project I-ORG of I-ORG Qingdao I-ORG of I-ORG China I-ORG No. O 16-5-1-16-jch B-AWARD and O a O regulatory O science O grant O under O the O FDA O Nanotechnology O CORES O Program O This O work O is O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61874122 O 21703251 O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDB20000000 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFB0701001 O 100 O talents O program O of O CAS O and O Fujian O Province O The O project O was O supported O by O a O grant O from O the O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG 973 I-ORG Program I-ORG of I-ORG China I-ORG No. O 2015CB150300 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFD0501200 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31602041 B-AWARD 31372426 B-AWARD This O study O is O supported O by O the O No. O 2021YJ013 B-AWARD research O project B-ORG from I-ORG Mianyang I-ORG Central I-ORG Hospital O by O the O No. B-AWARD S20074 I-AWARD research O project B-ORG from I-ORG the I-ORG Medicine I-ORG Association I-ORG of I-ORG Sichuan I-ORG Province I-ORG and O by O the O No. O 2022NSFSC1603 B-AWARD research O project B-ORG from I-ORG the I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Sichuan I-ORG Province I-ORG This O work O was O supported O by O the B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81372828 O 81271916 B-AWARD and O 81202077 B-AWARD the B-ORG key I-ORG project I-ORG of I-ORG Jiangsu I-ORG Provincial I-ORG Health I-ORG H201110 O to O Qiang O Ding O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20141023 O and O the B-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Traditional I-ORG Chinese I-ORG medicine I-ORG bureau I-ORG LZ11084 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O number O 81602066 B-AWARD and O 81772587 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O number O 16ykpy25 B-AWARD the O third O outstanding O young O talents O training O plan O and O Medical O Scientist O program O of O Sun O Yat-sen O University O cancer O center O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangzhou,China O Grant O number O 201510161726583 B-AWARD This O study O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O number O 2017YFC0907501 B-AWARD the O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG grant O number O NSFC-81473051 B-AWARD and O 81522040 B-AWARD and O the O Program O for O HUST B-ORG Academic I-ORG Frontier I-ORG Youth I-ORG Team I-ORG grant O number O 2017QYTD18 B-AWARD This O work O was O supported O by O a O grant O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31600615 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG Grant O No. O 2016JQ8023 B-AWARD as O well O as O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2015M582796 B-AWARD This O work O was O supported O by O the O Spanish B-ORG Ministerio I-ORG de I-ORG Ciencia I-ORG e I-ORG Innovación I-ORG AGL2014-55784-C2-2-R O by O the O Spanish B-ORG Ministerio I-ORG de I-ORG Educación I-ORG y I-ORG Ciencia I-ORG AGL2017-86531-C2-2-R O within O the O framework O of O the O FPU O program O PhD O fellowship O to O MP O and O by O MINECO B-ORG within O the O Ramon O y O Cajal O Program O BP) O from O the O Spanish O Government O RYC-2014-15111 O The O funders O have O no O role O in O the O study O design O data O analysis O and O interpretation O and O manuscript O writing O but O just O provide O the O financial O support O This O research O was O funded O by O the O U.S B-ORG National I-ORG Science I-ORG Foundation I-ORG NSF O under O EF-0830093 B-AWARD DBI-1266252 B-AWARD CBET-1530594 B-AWARD and O ECO-CBET B-AWARD 2133568 O Partial O support O was O also O provided O by O the O United B-ORG States I-ORG Department I-ORG of I-ORG Agriculture I-ORG National I-ORG Institute I-ORG of I-ORG Food I-ORG and I-ORG Agriculture I-ORG NIFA O multistate O project O NC1194 B-AWARD O.T O The O Caenorhabditis O Genetics O Center O CGC O is O funded O by O the O NIH B-ORG Office I-ORG of I-ORG Research I-ORG Infrastructure I-ORG Programs I-ORG P40 O OD010440 O This O study O was O funded O by O the O research B-ORG special I-ORG fund I-ORG for I-ORG public I-ORG welfare I-ORG industry I-ORG of I-ORG health I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Health I-ORG of O China O Grant O No. O 201202010 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81773454 B-AWARD and O China B-ORG Scholarship I-ORG Council I-ORG No. O 201806015008 B-AWARD This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81973233 B-AWARD the O Key B-ORG Laboratory I-ORG Open I-ORG Fund I-ORG of I-ORG Zhejiang I-ORG Mariculture I-ORG Research I-ORG Institute I-ORG No. O Z2021001 B-AWARD the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Province I-ORG China I-ORG No. O 2021C02062 B-AWARD the O Key B-ORG R&D I-ORG Program I-ORG of I-ORG Zhejiang I-ORG No. O 2022C03055 B-AWARD Zhejiang B-ORG Sci-Tech I-ORG University I-ORG and I-ORG Hangzhou I-ORG Zheda I-ORG Dixun I-ORG Biological I-ORG Gene I-ORG Engineering I-ORG Co I-ORG Ltd I-ORG Anti-Allergy I-ORG Functional I-ORG Molecular I-ORG Laboratory I-ORG Cooperation I-ORG Agreement I-ORG No. O 21040692-J B-AWARD This O work O was O sponsored O by O research O funding O from O Zhejiang B-ORG Provincial I-ORG Major I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG Grant O Nos I-AWARD 2014C03040-2 O Major B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Provincial I-ORG Medicine I-ORG and I-ORG Pharmacy I-ORG Grant O Nos I-AWARD KWJ-ZJ-1802 O and O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos I-AWARD 81,401,963 O This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81673282 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for O the O Central O Universities O lzujbky-2018-ot02 O and O the O National B-ORG Institute I-ORG of I-ORG Dental I-ORG and I-ORG Craniofacial I-ORG Research I-ORG R01 O DE027454-01A1 B-AWARD to O YC O This O research O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O No. O 61602388 B-AWARD by O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG under O Grant O No. O 2017M613216 B-AWARD by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG under O Grant O No. O 2452019064 B-AWARD by O the O Natural O Science O Basic O Research O Plan O in O Shaanxi O Province O of O China O under O Grant O No. O 2017JM6059 O by O the O Postdoctoral O Science O Foundation O of O Shaanxi O Province O of O China O under O Grant O No. O 2016BSHEDZZ121 O by O the O Ningxia O Smart O agricultural O Industry O Technology O Collaborative O Innovation O Center O under O Grant O No. O 2017DC53 O by O the O Key O Research O and O Development O Program O of O Shaanxi O under O Grant O No. O 2019ZDLNY07-06-01 O and O by O the O Innovation O and O Entrepreneurship O Training O Program O of O Northwest O A&F O University O of O China O under O Grant O No. O 201910712048 O This O study O was O financially O supported O by O grant O 2011/01/D/NZ9/00279 B-AWARD from O the O Poland B-ORG National I-ORG Science I-ORG Center O to O B.H.J O and O by O grants O BFU2015-65037-P B-AWARD from O Spain B-ORG Ministry I-ORG of I-ORG Economy I-ORG and I-ORG Competitiveness-FEDER O and O PROMETEOII/2014/021 B-AWARD from O Generalitat B-ORG Valenciana O to O S.F.E O This O work O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31571677 O Molecular B-ORG design I-ORG breeding I-ORG of I-ORG Maize I-ORG 2016YFD0101803 O Science B-ORG Foundation I-ORG for I-ORG The I-ORG Excellent I-ORG Youth I-ORG Scholars I-ORG of I-ORG Henan I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG 2016YQ03 O Industry B-ORG technology I-ORG system I-ORG of I-ORG Henan I-ORG Province I-ORG S2010-02-02 O Supported B-ORG by I-ORG Research I-ORG Program I-ORG of I-ORG Foundation I-ORG and I-ORG Advanced I-ORG Technology I-ORG of I-ORG Henan I-ORG Province I-ORG 0610032000 O All O these O funding O play O roles O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O project O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81472860 B-AWARD the O Key B-ORG R I-ORG I-ORG D I-ORG Project I-ORG of I-ORG Hunan I-ORG Province I-ORG grant O number O 2020DK2002 B-AWARD the O Key B-ORG Project I-ORG of I-ORG Developmental I-ORG Biology I-ORG and I-ORG Breeding I-ORG from I-ORG Hunan I-ORG Province I-ORG 2022XKQ0205 O and O the O research O start-up O fund O for O Prof O Peng O Xiaoning O from O Jishou B-ORG University I-ORG grant O number O 91602-111900 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Chinese B-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG CAMS I-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG CAMS-I2M O 2021-I2M-1-072 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG China I-ORG 2021YFF1000704 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32072722 O This O work O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U1913207 O 61233015 I-AWARD 61473131 O National B-ORG Program I-ORG on I-ORG Key I-ORG Basic I-ORG Research I-ORG Project I-ORG of I-ORG China I-ORG 973 O Program O 2013CB329506 B-AWARD and O the O Postdoctoral B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 2019M652652 O This O project O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 21676259 B-AWARD the O Key O Technologies O R O O D O Program O of O Anhui O Province O Nos O 17030901079 O 18030901079 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2019TQ0298 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG WK2060000007 O The O work O performed O in O the O groups O is O supported O by O grants O from O Institut B-ORG National I-ORG de I-ORG la I-ORG Santé I-ORG et I-ORG de I-ORG la I-ORG Recherche I-ORG Médicale I-ORG ENV201610 O and O Fondation B-ORG ARC I-ORG pour I-ORG la I-ORG Recherche I-ORG sur I-ORG le I-ORG Cancer I-ORG JA O 20151203192 O for O the O generation O of O the O data O using O NGS O that O were O used O in O this O study O and O by O Deutsche B-ORG Krebshilfe I-ORG no. O 110259 O and O the O National B-ORG Cancer I-ORG Institute I-ORG of O the O National O Institutes O of O Health O grant O 1R01-CA17758 B-AWARD for O the O collection O of O human O specimen O The O funding O body O played O did O not O play O roles O in O the O design O of O the O study O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O partially O funded O by O Fondo B-ORG Europeo I-ORG de I-ORG Desarrollo I-ORG Regional I-ORG PID2021-125694OB-I00 O cofounded O by O Vicerrectorado B-ORG de I-ORG Investigación I-ORG de I-ORG la I-ORG Universitat I-ORG Politècnica I-ORG de I-ORG València I-ORG PAID-11-21 O and O by O Ministerio B-ORG de I-ORG Universidades I-ORG Gobierno I-ORG de I-ORG España I-ORG FPU18/05105 O This O work O was O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG awarded O to O K.C.P O Grant O number O 31472130 B-AWARD and O by O the O Program B-ORG for I-ORG Changjiang I-ORG Scholars I-ORG and I-ORG Innovative I-ORG Research I-ORG Team I-ORG in I-ORG University I-ORG awarded O to O X.Q.N O Grant O number O IRT0848 B-AWARD and O by O the O Projects B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Research I-ORG Team I-ORG in I-ORG the I-ORG University I-ORG of I-ORG Sichuan I-ORG Province I-ORG awarded O to O K.C.P O Grant O number O KM406183.1 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O project O was O financially O supported O by O the O postgraduate O research O Institut B-ORG Pengurusan I-ORG dan I-ORG Pemantauan I-ORG Penyelidikan I-ORG IPPP O PG034-2012B O and O UMRG B-ORG FL001E-13BIO O grants O from O the O University B-ORG of I-ORG Malaya I-ORG and I-ORG Ministry I-ORG of I-ORG Higher I-ORG Education I-ORG for I-ORG the I-ORG High I-ORG Impact I-ORG Research I-ORG grant I-ORG UM-MOHE O MC/625/1/HIR/MOHE//SC/09 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 51701132 B-AWARD and O Research B-ORG Foundation I-ORG for I-ORG the I-ORG introduction I-ORG of I-ORG talent I-ORG of I-ORG Sichuan I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Engineering I-ORG China O grant O number O 2015RC57 B-AWARD and O the O Material B-ORG Corrosion I-ORG and I-ORG Protection I-ORG Key I-ORG Laboratory I-ORG of I-ORG Sichuan I-ORG province O grant O number O 2017CL05 B-AWARD Research O reported O in O this O publication O was O supported O by O the O National B-ORG Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases I-ORG of O the O National O Institutes O of O Health O under O Award O Number O R21AI128188 B-AWARD Florida B-ORG Department I-ORG of I-ORG Health I-ORG 7ZK15 O and O the O Florida B-ORG Department I-ORG of I-ORG Agriculture I-ORG and I-ORG Consumer I-ORG Services I-ORG contract O 024376 B-AWARD The O design O of O the O study O analysis O and O interpretation O of O data O and O writing O the O manuscript O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O NIH O FDH O or O FDACS O This O research O was O funded O by O an O AES-ISCIII O grant O from O the O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III I-ORG PI20CIII/00019 O co-financed O by O the O European O Development O Regional O Fund O “A O way O to O achieve O Europe” O FEDER O The O financial O support O of O PID2019-103899RB-I00 B-AWARD Spanish O Ministerio I-ORG de I-ORG Ciencia I-ORG e I-ORG Innovación O Research O Project O and O the O TRANSNANOAVANSENS-CM O program O from O the O Comunidad B-ORG de I-ORG Madrid I-ORG Grant O S2018/NMT-4349 B-AWARD to O S.C O are O also O gratefully O acknowledged O A.M.-C O is O supported O by O an O FPU O predoctoral O contract O of O the O Spanish O Ministerio O de O Educación O Cultura O y O Deporte O This O work O was O supported O by O the O Open B-ORG Project I-ORG Program I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Crop I-ORG Stress I-ORG Biology I-ORG for I-ORG Arid I-ORG Areas I-ORG NWAFU I-ORG No. O CSBAA2016016 O Research B-ORG Funds I-ORG from I-ORG Xinjiang I-ORG Agricultural I-ORG Vocational I-ORG Technical I-ORG College I-ORG No. O XJNZYKJ201501 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O Z109021565 O The O funders O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O study O was O funded O by O grant O from O the O Beijing B-ORG Medical I-ORG Management I-ORG Center I-ORG Cultivation I-ORG plan I-ORG PX2020071 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81672000 O and O the O Thirteen-Fifth B-ORG Key I-ORG Project I-ORG 2018ZX10715-005 O and O the O Beijing B-ORG Hospital I-ORG Authority I-ORG “Dengfeng” I-ORG Talent I-ORG Training I-ORG Plan I-ORG DFL20191802 O This O work O was O supported O in O part O by O grants O from O the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2012AA02A705 B-AWARD Design O of O the O study O the O Chinese B-ORG Ministry I-ORG of I-ORG Education I-ORG 111 I-ORG Project I-ORG B0803420 B-AWARD Collection O analysis O and O interpretation O of O data O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG Central I-ORG South I-ORG University I-ORG 2017zzts868 B-AWARD Writing O the O manuscript O This O work O was O supported O by O the O National B-ORG Major I-ORG Scientific I-ORG Instruments I-ORG Development I-ORG Project I-ORG 2012YQ03026007 O Shanghai B-ORG Municipal I-ORG Commission I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG 14JC1403700 O Program B-ORG of I-ORG Shanghai I-ORG Subject I-ORG Chief I-ORG Scientist I-ORG 17XD1401700 O The O work O was O financed O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O No. O 21867010 B-AWARD National B-ORG Demonstration I-ORG Centre I-ORG for I-ORG Experimental I-ORG Chemistry I-ORG Education I-ORG grant O No. O 2018ZXCX17 B-AWARD and O a O Graduate O Research O Innovation O Project O supported O by O Jishou B-ORG University I-ORG grant O No. O JGY201842 B-AWARD This O research O was O funded O by O Grants-in-Aid O for O Scientific O Research O B) O 17H02094 O to O Y.Y O from O the O Ministry B-ORG of I-ORG Education I-ORG Culture I-ORG Sports I-ORG Science I-ORG and I-ORG Technology O the O Japanese O Government O MEXT O Project O for O Translational O and O Clinical O Research O Core O Centers O A150 O to O Y.Y O from O Japan B-ORG Agency I-ORG for I-ORG Medical I-ORG Research I-ORG and I-ORG Development I-ORG AMED O and O a O grant O from O the O Asahi B-ORG Glass I-ORG Foundation I-ORG to O Y.Y O and O Y.T O This O study O was O supported O by O the B-ORG Jiangsu I-ORG Province’s I-ORG clinical I-ORG medical I-ORG science I-ORG and I-ORG technology I-ORG program I-ORG No. O BL2013016 B-AWARD the O Chinese B-ORG National I-ORG 863 I-ORG Major I-ORG Grant I-ORG No. O 2012AA020905 B-AWARD and O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81301267 B-AWARD This O research O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grants O 81571005 O 51305208 B-AWARD This O work O was O also O funded O by O the O Joint B-ORG Funds I-ORG of I-ORG Nanjing I-ORG Medical I-ORG University I-ORG and I-ORG Southeast I-ORG University I-ORG under O Grant O 2017DN02 O and O by O the O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O 2014-37 B-AWARD This O study O was O supported O by O the O Chinese B-ORG Nutrition I-ORG Society-Danone I-ORG Dietary I-ORG Nutrition I-ORG Research I-ORG and I-ORG Education I-ORG Fund I-ORG Grant O NO: O DIC2020-04 B-AWARD Yum B-ORG China I-ORG Dietary I-ORG Health I-ORG Foundation I-ORG Grant O NO: O CNS-YUM2020A19 B-AWARD Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Team I-ORG Support I-ORG Plan I-ORG of I-ORG Colleges I-ORG and I-ORG Universities I-ORG in I-ORG Henan I-ORG Province I-ORG Grant O NO:21IRTSTHN029 O National O Natural O Science O Foundation O of O China O Grant O NO: O 82003543 B-AWARD 42177415 B-AWARD Key O Research O Program O of O Colleges O and O Universities O in O Henan O Province O Grant O NO: O 21A330007 B-AWARD National B-ORG Key I-ORG Program I-ORG of I-ORG Research I-ORG and I-ORG Development I-ORG of I-ORG China I-ORG Grant O NO: O 2016YFC0900803 B-AWARD the O Key B-ORG Project I-ORG of I-ORG Hunan I-ORG provincial I-ORG science I-ORG and I-ORG technology I-ORG innovation I-ORG Grant O NO: O 2020sk1012 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG Grant O NO: O 2022JJ30547 O The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O research O was O supported O by O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG B) I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG grants O XDB B-AWARD 26000000 I-AWARD and I-AWARD 18000000 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O grants O 41672001 B-AWARD and I-AWARD 41688103 O the O International B-ORG Partnership I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG grant O 132311KYSB20170022 B-AWARD and O the O Key B-ORG research I-ORG program I-ORG of I-ORG Frontier I-ORG Sciences I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG grant O QYZDB-SSW-DQC040 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O received O financial O support O to O KDV O from O the O Agence B-ORG Nationale I-ORG de I-ORG la I-ORG Recherche O ANR-19-CE35-0004 O ArboVec O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIAID I-ORG AI145999 O and O French B-ORG Laboratoire I-ORG d’Excellence I-ORG “Integrative I-ORG Biology I-ORG of I-ORG Emerging I-ORG Infectious I-ORG Diseases” I-ORG ANR-10-LABX-62-IBEID O and O to O ABF O from O the O Agence O Nationale O de O la O Recherche O ANR-19-CE35-0004 O ArboVec O and O French O Laboratoire O d’Excellence O “Integrative O Biology O of O Emerging O Infectious O Diseases” O ANR-10-LABX-62-IBEID O The O funders O had O no O role O in O study O design O data O collection O and O analysis O the O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O by O National B-ORG Science I-ORG and I-ORG Technology I-ORG Pillar I-ORG Program I-ORG Grant O number O 2013BAD12B02 B-AWARD Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG CAFS I-ORG no. O 2017GH01 B-AWARD Special B-ORG Scientific I-ORG Research I-ORG Funds I-ORG for I-ORG Central I-ORG Non-profit I-ORG Institutes I-ORG Chinese I-ORG Academy I-ORG of I-ORG Fishery I-ORG Sciences I-ORG Grant O number O 2016HY-ZC0601 B-AWARD and O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG Grant O number O CARS-46 B-AWARD This O work O was O supported O by O the B-ORG Nitural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No.BK20171167 O and O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO. O 31401333 O the B-ORG Six I-ORG Talent I-ORG Peaks I-ORG Project I-ORG in I-ORG Jiangsu I-ORG Province I-ORG No. O 2015-NY-040 O and O the B-ORG China I-ORG Agricultural I-ORG Research I-ORG System I-ORG No. O CARS-11 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O grants O from O the O British B-ORG Heart I-ORG Foundation I-ORG ref O PG/11/51/28986 B-AWARD and O SP B-AWARD 14/4/31123 O The O funder O had O no O involvement O in O data O analysis O data O interpretation O or O writing O of O the O paper O DAL O works O in O a O unit O that O receives O funding O from O the O University O of O Bristol O and O UK O Medical B-ORG Research I-ORG Council I-ORG MC_UU_1201/5 O she O is O also O a O UK B-ORG National I-ORG Institute I-ORG of I-ORG Health I-ORG and I-ORG Research I-ORG Senior O Investigator O NF-SI-0166-10196 O The O funders O had O no O involvement O in O data O analysis O data O interpretation O or O writing O of O the O paper O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81271692 B-AWARD the O Ocean O Antithrombotic O Fibrinolytic O Enzyme O Gene O Bank O of O Taiwan O Strait O No. O 2014FJPT08 O the O Science O and O Technology O Innovation O Public O Technology O Service O Platform O of O Function O of O Drugs O and O Food O No. O 3502Z20141015 O Huaqiao B-ORG University I-ORG No. O 14BS-111 B-AWARD Education B-ORG Department I-ORG of I-ORG Fujian I-ORG Province I-ORG No. O JA14020 B-AWARD the O Science O and O Technology O Bureau O of O Quanzhou O City O No. O 2018Z012 O and O Subsidized O Project O for O Cultivating O Postgraduates’ O Innovative O Ability O in O Scientific O Research O of O Huaqiao O University O No. O 1601116004 O This O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 81802512 B-AWARD and O 81372506 B-AWARD the B-ORG project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Sichuan I-ORG Province I-ORG no. O 2018FZ0115 B-AWARD and O full-time B-ORG post-doctoral I-ORG research I-ORG and I-ORG development I-ORG foundation I-ORG of I-ORG Sichuan I-ORG University I-ORG no. O 2018SCU12034 B-AWARD This O work O was O funded O by O the O Yunnan O Province O Applied O and O Basic O Research O University O Joint O Project O of O Yunnan B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG Grant O Number O 2017FH00-033 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Number O 31960702 B-AWARD 31522057 B-AWARD and O 31872451 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O Number O 2662015PY227 B-AWARD This O study O was O supported O by O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81872637,81728017,81602868 O Shanghai B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG 201840324,20164Y0095 O Project O of O Shanghai O Collaborative O Innovation O Center O for O Translational O Medicine O TM201720 O Program O of O National O Science O and O Technology O Commission O for O association O of O diabetes O and O nutrition O in O adolescent O 2016YFC1305203 O Medical O and O Engineering O Cooperation O Project O of O Shanghai O Jiao O Tong O University O YG2017ZD15],The O Project O of O Shanghai O Children’s O Health O Service O Capacity O Construction O GDEK201708 O National O Human O Genetic O Resources O Sharing O Service O Platform O 2005DKA21300 O Science B-ORG and I-ORG Technology I-ORG Development I-ORG Program I-ORG of I-ORG Pudong I-ORG Shanghai I-ORG New I-ORG District I-ORG PKJ2017-Y01 O Science O Innovation O Funding O of O Shanghai O Jiaotong O University O School O of O Medicine O Z2016–02 O and O Shanghai B-ORG Professional I-ORG and I-ORG Technical I-ORG Services I-ORG Platform I-ORG 18DZ2294100 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O or O preparation O of O the O manuscript O Financial O support O was O received O from O the O Pontifical B-ORG Catholic I-ORG University I-ORG of I-ORG Ecuador I-ORG E13037 O G13042 I-AWARD J13066 I-AWARD L13254 I-AWARD and I-AWARD M13480 O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG Fogarty I-ORG International I-ORG Center I-ORG Global I-ORG Infectious I-ORG Disease I-ORG Training I-ORG Grant I-ORG 1D43TW008261-01A1 O and O the O National B-ORG Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases I-ORG Division I-ORG of I-ORG Microbiology I-ORG and I-ORG Infectious I-ORG Diseases I-ORG Academic I-ORG Research I-ORG Enhancement I-ORG Award I-ORG 1R15AI077896-01 O This O work O is O supported O by O National O Institutes O of O Health O National O Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases I-ORG 1R01AI114310-01 O UNC-South O China O STD O Research O Training O Center O Fogarty O International I-ORG Center I-ORG 1D43TW009532-01 B-AWARD UNC O Center O for O AIDS O Research O National O Institute O of O Allergy O and O Infectious O Diseases O 5P30AI050410 B-AWARD University O of O California O San O Francisco O Center O for O AIDS O Research O National O Institute O of O Allergy O and O Infectious O Diseases O P30 B-AWARD AI027763 O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health I-ORG R00MH093201 O UJMT O Fogarty O Fellowship O FIC O R25TW0093 O and O SESH O Global O www.seshglobal.org O This O work O also O receives O administrative O assistance O from O the O Guangdong O Provincial O Center O for O Skin O Diseases O and O STI O Control O UNC O Chapel O Hill O and O UNC O Project-China O in O Guangzhou O China O The O listed O grant O funders O played O no O role O in O any O step O of O this O study O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 51505498 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province O grant O number O BK20150714 B-AWARD National O Key O R O O D O Program O of O China O grant O number O 2016YFC0802900 O Hong B-ORG Kong I-ORG Scholars I-ORG Program O grant O number O XJ2017025 B-AWARD This O research O was O funded O by O the O Science B-ORG and I-ORG Technology I-ORG Foundation I-ORG of I-ORG Guizhou I-ORG Province O Grant/Award O Number O Qiankehe B-AWARD 2020]1Y140 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O Grant/Award O Numbers O 42003065 B-AWARD and O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation O Grant/Award O Number O 2019M663571 B-AWARD This O research O was O funded O by O the O Hong B-ORG Kong I-ORG Scholars I-ORG Program I-ORG Grant O No. O XJ2020012 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81902431 B-AWARD the O Excellent B-ORG Youth I-ORG Project I-ORG of I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Heilongjiang I-ORG Grant O No. O YQ2019H007 B-AWARD the O Special B-ORG Project I-ORG of I-ORG China I-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2019T120279 B-AWARD the O Special B-ORG Project I-ORG of I-ORG Heilongjiang I-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O LBH-TZ1016 B-AWARD the O China O Postdoctoral O Science O Foundation O Grant O No. O 2018M641849 B-AWARD and O 2018M640311 B-AWARD the O Heilongjiang O Postdoctoral O Science O Foundation O Grant O No. O LBH-Z18107 B-AWARD and O LBH-Z18112 B-AWARD the O Marshal B-ORG Initiative I-ORG Funding I-ORG of I-ORG Harbin I-ORG Medical I-ORG University I-ORG Grant O No. O HMUMIF-22008 B-AWARD the O Thematic B-ORG Research I-ORG Support I-ORG Scheme I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Liver I-ORG Research I-ORG University I-ORG of I-ORG Hong I-ORG Kong I-ORG Grant O No. O SKLLR/TRSS/2022/08 B-AWARD the O Beijing B-ORG Xisike I-ORG Clinical I-ORG Oncology I-ORG Research I-ORG Foundation I-ORG Grant O No. O Y-Young2022-0188 B-AWARD the O Medjaden B-ORG Academy I-ORG I-ORG Research I-ORG Foundation I-ORG for I-ORG Young I-ORG Scientists I-ORG Grant O No. O MJR20220903 B-AWARD the O Opening B-ORG Project I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Chemical I-ORG Oncogenomics O the O Opening O Project O of O Key O Laboratory O of O Basic O Pharmacology O of O Ministry O of O Education O Zunyi O Medicial O University O Grant O No. O 2022-449 B-AWARD the O Opening B-ORG Research I-ORG Fund I-ORG of I-ORG Key I-ORG Laboratory I-ORG of I-ORG Gastrointestinal I-ORG Cancer I-ORG Fujian I-ORG Medical I-ORG University I-ORG Ministry I-ORG of I-ORG Education I-ORG Grant O No. O FMUGIC-202203 B-AWARD the O Opening B-ORG Project I-ORG of I-ORG Key I-ORG Laboratory I-ORG of I-ORG Environment I-ORG and I-ORG Health I-ORG Ministry I-ORG of I-ORG Education I-ORG Grant O No. O 2022GWKFJJ01 B-AWARD the O Opening B-ORG Project I-ORG of I-ORG Key I-ORG Laboratory I-ORG of I-ORG Functional I-ORG and I-ORG Clinical I-ORG Translational I-ORG Medicine I-ORG Fujian I-ORG Province I-ORG University I-ORG Grant O No. O XMMC-FCTM202205 B-AWARD the O Opening B-ORG Project I-ORG of I-ORG Guangxi I-ORG Laboratory I-ORG of I-ORG Enhanced I-ORG Recovery I-ORG after I-ORG Surgery I-ORG for I-ORG Gastrointestinal I-ORG Cancer I-ORG Grant O No. O GXEKL202204 B-AWARD the O Opening B-ORG Project I-ORG of I-ORG Key I-ORG Laboratory I-ORG of I-ORG Biomarkers I-ORG and I-ORG In I-ORG Vitro I-ORG Diagnosis I-ORG Translation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG Grant O No. O KFJJ-2022002 B-AWARD the O Opening B-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Engineering I-ORG Research I-ORG Center I-ORG of I-ORG Tumor I-ORG Targeted I-ORG Nano I-ORG Diagnostic I-ORG and I-ORG Therapeutic I-ORG Materials I-ORG Grant O No. O JETNM202210 B-AWARD the O Opening B-ORG Project I-ORG of I-ORG the I-ORG Key I-ORG Laboratory I-ORG of I-ORG Intelligent I-ORG Pharmacy I-ORG and I-ORG Individualized I-ORG Therapy I-ORG of I-ORG Huzhou I-ORG I-ORG Changxing I-ORG Anti-cancer I-ORG Association I-ORG Grant O No. O NZKF-20230203 B-AWARD the O Opening B-ORG Project I-ORG of I-ORG the I-ORG Fujian I-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Innovative I-ORG Drug I-ORG Target I-ORG Research I-ORG Grant O No. O FJ-YW-2022KF03 B-AWARD In O this O work O the B-ORG Key I-ORG Project I-ORG at I-ORG Central I-ORG Government I-ORG Level I-ORG grant O numbers O 2060302 B-AWARD have O supported O for O ITS O and O V3V4 O sequencing O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 81960694 B-AWARD have O supported O for O buyG O eletajuvenile O tuber O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG grant O numbers O 2017YFC700703 B-AWARD have O supported O forG O eletaplant O experiment O National B-ORG Technical I-ORG System I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG Industry I-ORG grant O numbers O CARS-21 B-AWARD have O supported O forG O eletaplanting O base O rental O fee O the O High-level I-ORG Innovative I-ORG Talents I-ORG of I-ORG Guizhou I-ORG Province I-ORG of I-ORG China I-ORG Qian O Ke I-AWARD He I-AWARD Platform I-AWARD and I-AWARD Talent I-AWARD 2018]5638 O have O supported O for O transportation O to O and O from O theG O eletaplanting O base O the B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG in I-ORG Guizhou I-ORG Province I-ORG of I-ORG China I-ORG Qian O Ke I-AWARD He I-AWARD Platform I-AWARD and I-AWARD Talent I-AWARD 2019]5611 O have O supported O for O cultivateA O mellea O Guizhou B-ORG Education I-ORG Department I-ORG Innovation I-ORG Group I-ORG Major I-ORG Research I-ORG Projects I-ORG Qian O Jiao I-AWARD He I-AWARD KY I-AWARD Zi I-AWARD 2018]022 O have O supported O for O graduate O subsidy O Science B-ORG and I-ORG Technology I-ORG Plan I-ORG of I-ORG Guizhou I-ORG Province I-ORG Qian O Ke I-AWARD He I-AWARD Zhi I-AWARD Cheng I-AWARD 2018]2764 O have O supported O for O publication O fee O This O work O was O supported O by O the O Deutsche B-ORG Forschungsgemeinschaft I-ORG grant O SFB B-AWARD TRR I-AWARD 57 I-AWARD P18 O H2020 B-ORG European I-ORG Institute I-ORG of I-ORG Innovation I-ORG and I-ORG Technology I-ORG grant O 668031 B-AWARD and O Fundación B-ORG Cellex I-ORG PREDICT O grant O to O JT. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O the B-ORG 2012 I-ORG Shaanxi I-ORG Province I-ORG Fund I-ORG for I-ORG Returnees I-ORG Scientists I-ORG from I-ORG Foreign I-ORG Study I-ORG A289021201 O China B-ORG Scholarship I-ORG Council I-ORG Project I-ORG 22861057 O Initiation O Grant O to O Dr. O Yizhen O Wan O as O the O Emeritus O Professor O by O Jiangsu O University O of O Science O and O Technology O USA B-ORG NIH I-ORG grants I-ORG R01GM070795 O and O R01GM059138 B-AWARD to O Kai O Tang O and O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31101166 O to O Dayong O Zhang O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by: O Hertz B-ORG Foundation I-ORG George B-AWARD Lerman I-AWARD Fellowship O GG,www.hertzfoundation.org O Office B-ORG of I-ORG Naval I-ORG Research I-ORG under O Grant O N000141010278 B-AWARD EN,www.onr.navy.mil O and O National B-ORG Institutes I-ORG of I-ORG Health I-ORG under O Grant O R01DA040990-01 B-AWARD EN,www.nih.gov O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Netherlands B-ORG Organisation I-ORG for I-ORG Scientific I-ORG Research I-ORG NWO I-ORG TOP I-ORG grant O 854.11.003 O to O J.K O ALW B-ORG grant O 823.01.014 O to O J.K O Veni B-ORG fellowship I-ORG 863.13.017 O to O S.A.K O and O Natural B-ORG Environment I-ORG Research I-ORG Council I-ORG NERC O grant O NE/K005502/1 O to O D.S.R O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 51961008 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Joint I-ORG Fund O grant O number O U20A20276 B-AWARD and O the O Guangxi B-ORG Natural I-ORG Science I-ORG Foundation O grant O number O 2020GXNSFAA297269 B-AWARD This O project O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grants O 81400862 B-AWARD and O 81401606 B-AWARD the O Key B-ORG Project I-ORG in I-ORG the I-ORG Science I-ORG I-ORG Technology I-ORG Program I-ORG of I-ORG Sichuan I-ORG Province I-ORG Grant O No: O 2019YFS0322 B-AWARD and O the O Science B-ORG Foundation I-ORG for I-ORG The I-ORG Excellent I-ORG Youth I-ORG Scholars I-ORG of I-ORG Sichuan I-ORG University I-ORG Grants O 2015SU04A15 B-AWARD This O work O was O supported O by O the B-ORG Hospital I-ORG Fund I-ORG of I-ORG the I-ORG First I-ORG Affiliated I-ORG Hospital I-ORG of I-ORG Xi’an I-ORG Jiaotong I-ORG University O China O grant O number O 2016QN-29 B-AWARD 2019ZYTS-13 B-AWARD the B-ORG Funds I-ORG for I-ORG Clinical I-ORG Research I-ORG Center I-ORG for I-ORG Thyroid I-ORG Diseases I-ORG of I-ORG Shaanxi I-ORG Province I-ORG grant O number O 2017LCZX-03 B-AWARD the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG Central I-ORG Universities I-ORG grant O number O xjj2016106 B-AWARD and O the B-ORG Basic I-ORG Natural I-ORG Science I-ORG Research I-ORG Program I-ORG of I-ORG Shaanxi I-ORG Province I-ORG grant O numbers O 2017JM8072 B-AWARD 2017JM8179 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 42077092 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China O grant O number O 2017YFD0300104 B-AWARD Jiangsu B-ORG Carbon I-ORG Peak I-ORG Carbon I-ORG Neutrality I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Fund O grant O number O BE2022308 B-AWARD the O Opening B-ORG Fund I-ORG of I-ORG Fujian I-ORG Key I-ORG Laboratory I-ORG of I-ORG Plant I-ORG Nutrition I-ORG and I-ORG Fertilizer O grant O number O 2022PNFKL21 B-AWARD This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31772566 O the O State B-ORG Scholarship I-ORG Fund I-ORG of I-ORG China I-ORG Scholarship I-ORG Council I-ORG 201808340031 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Province I-ORG 1708085MC61 O the O Anhui O Key O Research O and O Development O Program O 1804a07020128 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2018YFD0502001 O the O Key O Research O Projects O of O Natural O Science O in O Anhui O Colleges O and O Universities O KJ2017A334 O and O the O Agricultural O Science O and O Technology O Innovation O Program O of O China O ASTIP-IAS13 O And O the O APC O was O funded O by O the O National O Natural O Science O Foundation O of O China O 31772566 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Medical B-ORG Research I-ORG Council I-ORG 1732344 O to O K.D.F O MC_UU_12017/11 B-AWARD MC_UU_12017/13 B-AWARD MC_UU_12017/14 B-AWARD MC_UU_12017/15 B-AWARD the O Chief B-ORG Scientist I-ORG Office I-ORG SCAF/15/02 B-AWARD to O S.V.K O and O the O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG 11/3005/40 O to O S.V.K O This O study O was O funded O by O the B-ORG Second I-ORG Tibetan I-ORG Plateau I-ORG Scientific I-ORG Expedition I-ORG and I-ORG Research I-ORG Program O Grant/Award O Number O 2019QZKK0304 B-AWARD the B-ORG Ministry I-ORG of I-ORG Ecology I-ORG and I-ORG Environment I-ORG Biodiversity I-ORG Survey I-ORG and I-ORG Assessment I-ORG Project O Grant/Award O Number O 2019HJ2096001006 B-AWARD and O the B-ORG Central I-ORG guide I-ORG local I-ORG project I-ORG for I-ORG science I-ORG and I-ORG technology I-ORG development O Grant/Award O Number O XZ202201YD0015C B-AWARD This O work O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG through O Grants O 61402094 B-AWARD and O 61702089 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG through O Grants O F2016501076 B-AWARD and O F2016501079 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province I-ORG through O Grant O 201602254 B-AWARD the O Fundamental O Research O Funds O for O the O Central O Universities O through O Grant O N172304022 O the O Science O and O Technology O Plan O Project O of O Guangzhou O through O Grant O 201804010433 O and O the O Bidding O Project O of O Laboratory O of O Language O Engineering O and O Computing O through O Grant O LEC2017ZBKT001 O This O work O was O financially O supported O by O a O commissioned O grant O from O the O Health B-ORG and I-ORG Medical I-ORG Research I-ORG Fund I-ORG grant O no. O HKS-16-E10 B-AWARD and O by O grants O from O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG grant O no. O U54 B-AWARD GM088558 O and O the O Hong B-ORG Kong I-ORG Research I-ORG Grants I-ORG Council I-ORG project O no. O T11-705/14 B-AWARD N). O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51201107 O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Advanced I-ORG Optical I-ORG Communication I-ORG Systems I-ORG and I-ORG Networks I-ORG 2018GZKF03007 O the O manufacturing B-ORG principle I-ORG and I-ORG performance I-ORG control I-ORG theory I-ORG of I-ORG magnesium/heterogeneous I-ORG metal I-ORG composites I-ORG a I-ORG major I-ORG project I-ORG of I-ORG basic I-ORG and I-ORG applied I-ORG basic I-ORG research I-ORG in I-ORG Guangdong I-ORG Province I-ORG 2020B0301030006 O and O Guangdong B-ORG Academy I-ORG of I-ORG Sciences I-ORG has O established O a O special O fund O project O for O the O construction O of O first-class O research O institutions O in O China O and O a O new O generation O of O metal O matrix O composite O interface O and O performance O control O and O application O 2020GDSKXYL-20200101001 O Funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81560611 B-AWARD Hainan B-ORG Provincial I-ORG Keypoint I-ORG Research I-ORG and I-ORG Invention I-ORG Program I-ORG No. O ZDYF2018138 B-AWARD China B-ORG Scholarship I-ORG Council I-ORG No. O 201708460079 B-AWARD and O the O Program B-ORG of I-ORG Hainan I-ORG Association I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG Plans I-ORG to I-ORG Youth I-ORG R I-ORG I-ORG D I-ORG Innovation I-ORG No. O 201513 B-AWARD This O research O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2022YFA1104900 O the O STI2030-Major B-ORG Projects I-ORG 2022ZD0214400 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O U1801287 B-AWARD 82073712 B-AWARD 82071535 B-AWARD 82101614 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Key I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG Nos O 2019B030335001 B-AWARD 2017BT01Y036 B-AWARD 2020B1111110004 B-AWARD the O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG Nos O 2022B151513007 B-AWARD 2023B1515040015 B-AWARD 2023A1515030012 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangzhou I-ORG City I-ORG No. O 20212210005 B-AWARD This O work O was O supported O by O the O following O grants O NIAID B-ORG 1R01AI101898 B-AWARD M.M O U01-AI107305 B-AWARD M.M O U01AI133594 B-AWARD M.M O and O H.H O VA B-ORG Merit I-ORG Review I-ORG 1 B-AWARD I01 I-AWARD BX001681 I-AWARD E.R.J O NHLBI B-ORG HL116530 B-AWARD E.R.J O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81830114 O No.81774164 B-AWARD No.81603509 B-AWARD No.81473557 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O China O No. O 2017A030313737 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province O China O No. O ZR2014HQ051 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51531006 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M641189 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG FRF-TP-18-090A1 O Author O Hanchen O Huang O acknowledges O the O sponsorship O of O US O Department O of O Energy O Office O of O Basic O Energy O Science O DE-SC0014035 O This O study O was O financed O in O part O by O the O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior—Brasil I-ORG CAPES)—Finance O Code O 001 B-AWARD by O the O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG do I-ORG Rio I-ORG Grande I-ORG do I-ORG Sul-FAPERGS I-ORG Grant O 21/2551-0001966-2 B-AWARD Brazil O and O by O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG CNPq I-ORG CAPES/PROEX I-ORG process O 23038.002125/2021-85 B-AWARD Grant O 0036/2021 B-AWARD Sara O Marchesan O Oliveira O is O the O recipient O of O an O award O from O CNPq O grant O 304985/2020-1 B-AWARD Gabriela O Becker O Maria O Fernanda O Pessano O Fialho O and O Indiara O Brusco O are O recipients O of O a O fellowship O from O CAPES/PROEX O processes O 88887.568915/2020-00 B-AWARD 88882.182170/2018-01 B-AWARD and O 88882.182148/2018-01 B-AWARD respectively O This O work O was O supported O by O Grants O 81200389 B-AWARD and O 81200058 B-AWARD from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG WW, O LN O Grant O 20120141120077 B-AWARD from O the B-ORG Specialized I-ORG Research I-ORG Fund I-ORG for I-ORG the I-ORG Doctoral I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG of I-ORG China I-ORG WW) O and O Grant O 2016CFB456 B-AWARD from O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG of I-ORG China I-ORG WW O This O work O was O supported O by O R01 B-ORG MH118257 B-AWARD to O SRH O DA B-ORG 038615 B-AWARD to O BYH O ASW O acknowledges O support O from O the O OneMind B-ORG Institute I-ORG and I-ORG the I-ORG National I-ORG Institutes I-ORG of I-ORG Health I-ORG UH3 O NS100548 I-AWARD R21 I-AWARD MH113103 I-AWARD R01 I-AWARD EB026938 I-AWARD R01 I-AWARD MH119384 O for O work O discussed O in O this O article O This O study O was O funded O by O the O Nature B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangxi I-ORG Province I-ORG grant O number O 2013GXNSFBA019162 B-AWARD Basic B-ORG Skills I-ORG Improving I-ORG Program I-ORG of I-ORG Young I-ORG Teachers I-ORG in I-ORG Guangxi I-ORG Colleges I-ORG and I-ORG Universities I-ORG grant O number O 2017KY0092 B-AWARD and O Guangxi B-ORG Medical I-ORG University I-ORG Youth I-ORG Science I-ORG Fund I-ORG grant O number O GXMUYSF201634 B-AWARD This O study O is O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Anhui I-ORG Province I-ORG No. O 1708085QF134 B-AWARD Anhui O Provincial O Major O Scientific O and O Technological O Special O Project O No. O 17030701062 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 3170123 B-AWARD Natural O Science O Research O Project O of O Anhui O Provincial O Education O Department O No. O KJ2018A0009 O and O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFD0800904 B-AWARD This O research O was O financially O supported O by O the B-ORG Guangdong I-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG 2017A050506041 O 2017B030314166 B-AWARD the B-ORG Guangdong I-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG Project I-ORG 2018KQNCX046 O the B-ORG Guangzhou I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 201807010051 O and O the B-ORG Guangdong I-ORG Provincial I-ORG Hospital I-ORG of I-ORG Chinese I-ORG Medicine I-ORG Special I-ORG Fund I-ORG YN2018HK01 O YN2018ZD08 B-AWARD YN2018RBA02 B-AWARD YN2016XP02 B-AWARD YN2019QJ04 B-AWARD YN2019QJ08 B-AWARD This O work O was O partially O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O J1103518 O Sichuan B-ORG province I-ORG scientific I-ORG support I-ORG program I-ORG No. O 2016KZ0006 O H130923 O and O Sichuan B-ORG Tongfeng I-ORG Sci I-ORG I-ORG Technol I-ORG Co. I-ORG Ltd I-ORG No. O 2010-01 O Tongfeng O Science O O Technology O Co. O Ltd O provided O support O in O the O form O of O salaries O for O authors O JMW O and O YH O but O did O not O have O any O additional O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O specific O roles O of O these O authors O are O articulated O in O the O ‘author O contributions’ O section O This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG LY20H010004 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81870022 O the B-ORG Medical I-ORG and I-ORG Health I-ORG Technology I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2017204226 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81273439 O CAMS B-ORG Initiative I-ORG for I-ORG Innovative I-ORG Medicine I-ORG CAMS-I2M-1-010 O the B-ORG Central I-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG IMBF201410 O and O the B-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG 2012ZX10004501-004-001 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31771619 B-AWARD to O H.H O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2022MD713708 B-AWARD to O W.Y O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Chongqing I-ORG China I-ORG No. O cstc2021jcyj-bsh-X0069 B-AWARD to O W.Y O This O study O was O supported O by O the O Beijing B-ORG Jishuitan I-ORG Hospital I-ORG Natural I-ORG Fund I-ORG Incubation I-ORG Program I-ORG Grant O No. O ZR-202304 B-AWARD Beijing B-ORG Municipal I-ORG Science I-ORG I-ORG Technology I-ORG Commission I-ORG Grant O No. O Z191100004419007 B-AWARD and O Beijing B-ORG Jishuitan I-ORG Hospital I-ORG Research I-ORG Funding I-ORG Grant O No. O XKGG201811 B-AWARD This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 31272028 B-AWARD National B-ORG Transgenic I-ORG Major I-ORG Project I-ORG of I-ORG China I-ORG No. O 2014ZX08009-003-001 B-AWARD and O No. O 2016YFD0100601 O and O Research B-ORG Fund I-ORG for I-ORG the I-ORG Doctoral I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG of I-ORG China I-ORG 20120101110070 O This O research O was O supported O by O the O Shanghai B-ORG Pujiang I-ORG Program I-ORG 16PJC063 O Shanghai B-ORG Science I-ORG and I-ORG technology I-ORG innovation I-ORG action I-ORG plan I-ORG 19DZ2203600 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 71502153 O 91746103 B-AWARD The O funder O was O not O involved O in O the O research O All O aspects O of O the O study O including O the O research O design O and O interpretation O of O findings O is O the O responsibility O of O the O authors O and O not O the O funder O This O study O was O supported O by O the B-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG Leaders I-ORG in I-ORG Central I-ORG Plains I-ORG Grant O No. O 194200510017 B-AWARD the O Provincial B-ORG Ministry I-ORG Co-Construction I-ORG Project I-ORG from I-ORG the I-ORG Medical I-ORG Scientific I-ORG and I-ORG Technological I-ORG Research I-ORG Program I-ORG of I-ORG Henan I-ORG Province I-ORG Grant O No. O SBGJ2018020 B-AWARD the O “51282” O Project O Leaders O of O Scientific O and O Technological O Innovative O Talents O from O Health O and O Family O Planning O Commission O in O Henan O Province O 2016-32 O and O the O Science B-ORG and I-ORG Technology I-ORG People-Benefit I-ORG Project I-ORG of I-ORG Zheng I-ORG Zhou I-ORG 2019KJHM0001 O This O study O was O funded O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41776121 O 41576123 B-AWARD the B-ORG Guangdong I-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2018A030313164 O 2016A030312004 B-AWARD 2015A030313326 B-AWARD and O the B-ORG International I-ORG Science I-ORG and I-ORG Technology I-ORG cooperation I-ORG project I-ORG GASI-IPOVI-04 O the B-ORG Strategic I-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDA11020304 O The O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31370104,31900038 O Hunan B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 2018JJ2497 O Shanxi O Province O Science O Foundation O for O Youths O 201801D221284 O Open O Grant O of O Beijing O Advanced O Innovation O Center O for O Food O Nutrition O and O Human O Health O 20182024 O Hunan B-ORG Provincial I-ORG Innovation I-ORG Foundation I-ORG For I-ORG Postgraduate I-ORG CX2017B074 O and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG Central I-ORG South I-ORG University I-ORG 2018zzts119 O 2018zzts392 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31370364 O 31570652 B-AWARD 31670200 B-AWARD 31770587 B-AWARD and O 31872670 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O China O 2016A030313320 O and O 2017A030313122 B-AWARD Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province O China O 2017A030303007 O Project O of O Department O of O Science O and O Technology O of O Shenzhen O City O Guangdong O China O JCYJ20160425165447211 O JCYJ20170413155402977 O JCYJ20170818155249053 O and O JCYJ20190813172001780 O and O Science O and O Technology O Planning O Project O of O Guangzhou O City O China O 201804010389 O This O work O was O supported O by O grants O from O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31371850 O 31772023 B-AWARD and O 31501575 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Henan I-ORG province I-ORG 162300410047 O and O the O Key B-ORG Program I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG of I-ORG Henan I-ORG province I-ORG 162102210191 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Financial O supports O were O received O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31601969 O IMAU B-ORG ‘Double-First I-ORG Class’ I-ORG Innovation I-ORG Group I-ORG Personnel I-ORG Training I-ORG Project I-ORG NDSC2018-04 O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Inner I-ORG Mongolia I-ORG 2018 O and O project B-ORG for I-ORG Mr. I-ORG Yang I-ORG Sheng I-ORG protege I-ORG community I-ORG C2016036 O The O funding O body O are O play O role O in O provide O research O funding O of O the O study.They O had O no O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O funded O by O Shanghai B-ORG Municipal I-ORG Commission I-ORG of I-ORG Science I-ORG and I-ORG technology I-ORG Grant O No. O 21N11900200 B-AWARD and O 23N11900100 B-AWARD the O earmarked O fund O for O China B-ORG Agriculture I-ORG Research I-ORG SystemRice I-ORG CARS-01 O the O Bill B-ORG and I-ORG Melinda I-ORG Gates I-ORG Foundation I-ORG INV-033236-3 O Research O reported O in O this O publication O was O supported O by O the O National B-ORG Institute I-ORG of I-ORG Diabetes I-ORG and I-ORG Digestive I-ORG and I-ORG Kidney I-ORG Diseases I-ORG of O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG under O Award O Number O R01DK104348 B-AWARD PI: O M. O Laska O as O well O as O the O Centers B-ORG for I-ORG Disease I-ORG Control I-ORG and I-ORG Prevention I-ORG under O Award O Number O U48DP005022 B-AWARD Additional O funding O for O formative O and O developmental O work O for O this O study O was O funded O by O the O University O of O Minnesota O Center O for O Urban O and O Regional O Affairs O as O well O as O the O Global O Obesity O Prevention O Center O GOPC O at O Johns O Hopkins O which O is O supported O by O the O Eunice B-ORG Kennedy I-ORG Shriver I-ORG National I-ORG Institute I-ORG of I-ORG Child I-ORG Health I-ORG and I-ORG Human I-ORG Development I-ORG NICHD O and O the O Office O of O the O Director O National O Institutes O of O Health O OD) O under O award O number O U54HD070725 B-AWARD Further O salary O support O provided O to O Dr. O Caspi O as O a O post-doctoral O fellow O was O provided O by O NIH O grant O 5R25CA163184 B-AWARD NCI O Cancer O Related O Health O Disparities O Education O and O Career O Development O Program O NIH O grant O UL1TR000114 B-AWARD from O the O National B-ORG Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences I-ORG NCATS O supported O data O management O The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O National O Institutes O of O Health O The O work O was O supported O by O the O National B-ORG Research I-ORG Development I-ORG and I-ORG Innovation I-ORG Office I-ORG Hungary O OTKA O K112070 O the O EFOP-3.6.1-16-2016-00007 B-AWARD project O of O the O European B-ORG Union I-ORG and I-ORG the I-ORG European I-ORG Regional I-ORG and I-ORG Development I-ORG Fund I-ORG and O the O Government B-ORG of I-ORG Hungary I-ORG within O the O project O GINOP-2.3.2-15-2016-00025 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O partially O supported O by O National O Key O R&D O Program O of O China O 2017YFC0108703 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61571380 O 6171101498 O U1632274 B-AWARD 61672335 B-AWARD 61601276 B-AWARD and O 61302174 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG of I-ORG China I-ORG 2018J06018 O 2016J05205 B-AWARD and O 2016J01327 B-AWARD Fundamental O Research O Funds O for O the O Central O Universities O 20720180056 O Foundation B-ORG of I-ORG Fujian I-ORG Educational I-ORG Committee I-ORG JAT160358 O and O Important B-ORG Joint I-ORG Research I-ORG Project I-ORG on I-ORG Major I-ORG Diseases I-ORG of I-ORG Xiamen I-ORG City I-ORG 3502Z20149032 O These O funding O bodies O do O not O play O any O role O in O the O design O of O the O study O and O in O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O financially O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 51605120 O 51675138 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017M621261 O 2018T110290 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFF0200601 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG HIT O NSRIF I-AWARD 2020103 O This O work O was O supported O by O the O Applied B-ORG Basic I-ORG Research I-ORG Foundation I-ORG of I-ORG Yunnan I-ORG Province I-ORG No. O 202101AS070042 B-AWARD the O Young B-ORG and I-ORG Middle-Aged I-ORG Academic I-ORG and I-ORG Technical I-ORG Leaders I-ORG Reserve I-ORG Talent I-ORG Project I-ORG of I-ORG Yunnan I-ORG Province I-ORG Grant O No. O 202105AC160031 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31572337 B-AWARD This O work O was O carried O out O by O the O Core O Program O Project B-AWARD 18N/2019 I-AWARD and O through O the O Core O Program O within O the O National B-ORG Research I-ORG Development I-ORG and I-ORG Innovation I-ORG Plan I-ORG 2022–2027 O carried O out O with O the O support O of O MCID B-ORG project O no. B-AWARD PN I-AWARD 23 I-AWARD 05 I-AWARD M.D O A.C.P O V.B O A.V O M.B O K.W O and O X.L O acknowledge O the O funding O from O US O NSF O award O CBET-2306177 B-AWARD for O the O work O at O Washington B-ORG University I-ORG St. I-ORG Louis I-ORG This O work O was O funded O by O grants O from O the O National B-ORG Science I-ORG Fund I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG 31425020 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31501419 O the B-ORG 111 I-ORG Project I-ORG No. O 111-2-06 B-AWARD and O the O Production B-ORG and I-ORG Research I-ORG Prospective I-ORG Joint I-ORG Research I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BY2015019-32 O BY2015019-18 B-AWARD This O work O was O supported O by O a O grant O of O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O funded O by O the O Korea O government O MEST O No. O 2015R1D1A1A09056771 O a O 2015 O Inje B-ORG University I-ORG research O grant O No. O 20151089 B-AWARD and O a O 2016 O basic-clinical O collaborative O research O grant O No. O SMX1161461 B-AWARD funded O by O Samsung B-ORG Biomedical I-ORG Research I-ORG Institute I-ORG SBRI O The O above O funders O had O no O role O in O study O design O in O data O collection O data O analysis O data O interpretation O writing O of O the O manuscript O or O decision O to O submit O this O manuscript O for O publication O This O work O was O supported O by O grants O from O Strategic B-ORG and I-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDA24030502 O XDA13020604 O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD1000607 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31770334 O Youth B-ORG Innovation I-ORG Promotion I-ORG Association I-ORG CAS I-ORG 2015286 O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG 201904010167 O The O funding O organizations O did O not O aid O in O designing O data O collection O analysis O data O interpretation O and O manuscript O write O up. O This O study O was O funded O by O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2018BLCB08 O by O the O construction O of O the O workstation O for O Academician B-ORG Bennetzen I-ORG 2015IC056 O from O Yunnan O Provinical O Science O and O Technology O Department O by O the O Breeding O of O new O variety O forMalania O oleiferaand O product O development O of O nervonic O acid O 2015BB018 O from O the O Science B-ORG Fund I-ORG of I-ORG China's I-ORG Yunnan I-ORG government O and O by O the O Natural O hybridization O and O reproductive O isolation O among O plants O with O high O horticulture O values O 2018428 O from O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG This O work O was O financially O supported O by O the O Key O Project O of O Department O of O Education O of O Guangdong O Province O 2016GCZX008 O Project O of O Foshan O Engineering O Research O Centre O 20172010018 O Key O Disciplines’ O Construction O Opening O Fund O of O Foshan O University O CGS06021 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61703152 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG No. O 2019JJ50127 B-AWARD 2018JJ3134 O Scientific B-ORG Research I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Provincial I-ORG Education I-ORG Department I-ORG 18A273 O 18C0522 O and O Undergraduates’ O Innovation O Experiment O Program O of O Hunan O Province O No. O 2018649 O This O work O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81200133 O Jiangsu B-ORG Top I-ORG Expert I-ORG Program I-ORG in I-ORG Six I-ORG Professions I-ORG 2013-WSN-032 O Jiangsu B-ORG Province I-ORG Health I-ORG Department I-ORG Program I-ORG Grant I-ORG Z201411 O Key B-ORG Project I-ORG supported I-ORG by I-ORG Medical I-ORG Science I-ORG and I-ORG technology I-ORG development I-ORG Foundation I-ORG Nanjing I-ORG Department I-ORG of I-ORG Health I-ORG JQX14006 O MMa O GK, O JM, O M.Z O and O OT O were O supported O by O funds O through O a O grant O from O the O Economic B-ORG and I-ORG Social I-ORG Research I-ORG Council I-ORG ESRCS O O ES/P004938/1 B-AWARD awarded O to O ME. O A O Senior O Research O Fellowship O awarded O to O ME O by O The O Wellcome B-ORG Trust I-ORG #207522 O supported O P.M O M O Maina O received O additional O support O from O a O grant O to O the O Initiative O to O Develop O African O Research O Leaders O IDeAL O through O the O DELTAS O Africa O Initiative O DEL-15-003 O an O independent O funding O scheme O of O the O African B-ORG Academy I-ORG of I-ORG Sciences I-ORG AAS)'s O Alliance O for O Accelerating O Excellence O in O Science O in O Africa O AESA O and O supported O by O the O New O Partnership O for O Africa's O Development O Planning O and O Coordinating O Agency O NEPAD O Agency O with O funding O from O the O Wellcome O Trust O 107769/Z/10/Z O and O the O UK O government O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No.31670315 O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O No.6194030 O the O National O Natural O Science O Foundation O of O China O Grant O No. O 31902026 B-AWARD Beijing B-ORG Excellent I-ORG Talent I-ORG Training I-ORG Project I-ORG to O H.H O Grant O No.66 O and O Scientific B-ORG Research I-ORG Project I-ORG of I-ORG Beijing I-ORG Municipal I-ORG Commission I-ORG of I-ORG Education I-ORG Grant O No.KM201910020013 O This O work O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O 61672297 B-AWARD in O part O by O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG under O Grant O BE2017742 B-AWARD in O part O by O the O Sixth B-ORG Talent I-ORG Peaks I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG under O Grant O DZXX-017 B-AWARD in O part O by O the O Jiangsu O Natural O Science O Foundation O for O Excellent O Young O Scholars O under O Grant O BK20160089 B-AWARD and O Grant O BK20170039 B-AWARD in O part O by O the O Postgraduate O Research O O Practice O Innovation O Program O of O Jiangsu O Province O under O Grant O KYCX19_0908 O and O in O part O by O the O Key O Project O on O Anhui O Provincial O Natural O Science O Study O by O Colleges O and O Universities O under O Grant O KJ2019A0579 O Supported O by O funds O from O the B-ORG National I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81570887 B-AWARD and O No. O 81600730 B-AWARD the B-ORG Shanghai I-ORG Committee I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG No. O 17410712500 B-AWARD and O the B-ORG top I-ORG priority I-ORG of I-ORG clinical I-ORG medicine I-ORG center I-ORG of I-ORG Shanghai I-ORG No. O 2017ZZ01020 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O E.S.-P O was O supported O by O a O Beca-Chile B-ORG ANID I-ORG Postdoctoral I-ORG grant O number O 74190055 B-AWARD D.P.-C O was O supported O by O Program B-ORG Institucional I-ORG de I-ORG Internacionalização I-ORG PRINT O grant O number O 88887.508140/2020-00 B-AWARD and O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior—Brasil I-ORG CAPES—001 O J.L.-T O holds O a O Sir O Henry O Wellcome O fellowship O from O the O Wellcome B-ORG Trust I-ORG UK I-ORG grant O number O 220456/Z/20/Z B-AWARD A.N.S.-P O holds O an O MRC B-ORG New I-ORG Investigator I-ORG Award I-ORG grant O number O RG93186 B-AWARD and O Lister B-ORG Institute I-ORG of I-ORG Preventative I-ORG Medicine I-ORG grant O number O RG93692 B-AWARD This O study O was O financially O supported O by O Shanghai B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Grant O No. O 20174Y0237 B-AWARD Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG Grant O No.18140900302 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81870517 O This O study O was O supported O by O grants O from O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O No. O 81472272 B-AWARD and O 81602114 B-AWARD the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG of I-ORG Jiangsu I-ORG Province I-ORG no. O BE2019692 B-AWARD the O Postdoctoral B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O No. O 2017M620221 B-AWARD the O Social B-ORG Development I-ORG Foundation I-ORG of I-ORG Nantong I-ORG City I-ORG grant O no. O MS22018006 B-AWARD MS12019018 B-AWARD MS12019020 B-AWARD JC2019032 B-AWARD and O the O Teaching B-ORG Research I-ORG Project I-ORG of I-ORG Affiliated I-ORG Hospital I-ORG of I-ORG Nantong I-ORG University I-ORG Tfj O 18006 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O received O funding O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO.82001764 O Peking B-ORG University I-ORG People’s I-ORG Hospital I-ORG Scientific I-ORG Research I-ORG Development I-ORG Funds I-ORG RDY2020-08 O RS2021-10 O and O Beijing B-ORG United I-ORG Imaging I-ORG Research I-ORG Institute I-ORG of I-ORG Intelligent I-ORG Imaging I-ORG Foundation I-ORG CRIBJQY202105 O The O funding O agencies O above O provided O support O in O study O design O data O collection O analysis O and O interpretation O and O manuscript O writing O This O work O was O supported O by O the O Canadian B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG CIHR O Foundation O grant O FDN-148439 B-AWARD KCK O Canada O Research O Chair O KCK O Open O Philanthropy O KCK O MD/PhD O Studentship O REE O and O Vanier O Canada O Graduate O Scholarship O REE O The O main O trial O was O supported O by O a O grant O from O the O European B-ORG I-ORG Developing I-ORG Countries I-ORG Clinical I-ORG Trials I-ORG Partnership I-ORG Award O Number O IP.2007.31080.003 B-AWARD supplemented O by O funds O from O the O Malaria O in O Pregnancy O Consortium O which O is O funded O through O a O grant O by O the O Bill B-ORG I-ORG Melinda I-ORG Gates I-ORG Foundation I-ORG to O the O Liverpool O School O of O Tropical O Medicine O Award O Number O 46099 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31722011 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0600705 O and O Beijing B-ORG Forestry I-ORG University I-ORG Outstanding I-ORG Young I-ORG Talent I-ORG Cultivation I-ORG Project I-ORG 2019JQ03004 O This O work O was O supported O by O the O High-level B-ORG Talent I-ORG Project I-ORG of I-ORG Xinjiang I-ORG Uygur I-ORG Autonomous I-ORG Region I-ORG 2020000039 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 52002398 O and O the O Xinjiang B-ORG Key I-ORG Laboratory I-ORG of I-ORG Electronic I-ORG Information I-ORG Materials I-ORG and I-ORG Devices I-ORG 2017D04029 O This O study O was O financially O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31660573 O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-25-C-04 O and O the B-ORG Guangxi I-ORG Innovation I-ORG Team I-ORG Project I-ORG of I-ORG Vegetable I-ORG of I-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG nycytxgxcxtd-03-10 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O grants O CGL2012-36970 B-AWARD CGL2015-70390-P B-AWARD from O the O Ministerio B-ORG de I-ORG Economía I-ORG y I-ORG Competitividad O Spain O cofunded O by O FEDER O the O project O ‘Field O study O for O the O conservation O of O reptiles O in O Oman’ O Ministry B-ORG of I-ORG Environment I-ORG and I-ORG Climate I-ORG Affairs O Oman O Ref O 22412027 B-AWARD and O grant O 2014-SGR-1532 B-AWARD from O the O Secretaria B-ORG d’Universitats I-ORG i I-ORG Recerca I-ORG del I-ORG Departament I-ORG d’Economia I-ORG i I-ORG Coneixement I-ORG de I-ORG la I-ORG Generalitat I-ORG de I-ORG Catalunya O MSR O is O funded O by O a O FPI O grant O from O the O Ministerio O de O Economía O y O Competitividad O Spain O BES-2013-064248 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O paper O reports O on O an O independent O study O which O was O funded O by O the O Policy O Research O Programme O in O theDepartment O of I-ORG Health I-ORG England(grant O 108/0001 B-AWARD The O views O expressed O are O not O necessarily O those O of O the O Department O TheUK O Medical I-ORG Research I-ORG Council(Grant O ref B-AWARD 102215/2/13/2 B-AWARD and O theWellcome O Trust(grant O 102215/2/13/2 O and O the O University O of O Bristol O provide O core O support O for O ALSPAC O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81770150 B-AWARD the B-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangzhou I-ORG City I-ORG of I-ORG China I-ORG No. O 201804010425 B-AWARD and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 21617465 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 22162017 B-AWARD the B-ORG Key I-ORG Research I-ORG Projects I-ORG of I-ORG Henan I-ORG Higher I-ORG Education I-ORG Institutions I-ORG CN) O Grant O No. O 21A350001 B-AWARD the O Top B-ORG Science I-ORG and I-ORG Technology I-ORG Talents I-ORG Project I-ORG of I-ORG Guizhou I-ORG Education I-ORG Department I-ORG [2020]038 O the B-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Materials-Oriented I-ORG Chemical I-ORG Engineering I-ORG No. O KL-MCE-22B01 B-AWARD Guizhou B-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Coal I-ORG Clean I-ORG Utilization I-ORG [2020]2001 O and O Guizhou B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG China I-ORG No. O QKHPTRC[2019]5907 B-AWARD This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81602905 O to O YDhttp://www.nsfc.gov.cn O Municipal B-ORG Human I-ORG Resources I-ORG Development I-ORG Program I-ORG for I-ORG Outstanding I-ORG Young I-ORG Talents I-ORG in I-ORG Medical I-ORG and I-ORG Health I-ORG Sciences I-ORG in I-ORG Shanghai I-ORG 2018YQ57 O to O YD, O Foundation B-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG 20164Y0245 O to O YD, O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG 16ZR1429900 O to O YL. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81670777 B-AWARD Key B-ORG Medical I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG of I-ORG Zhejiang I-ORG Province I-ORG grant O number O WKJ-ZJ-1625 B-AWARD Wenzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG Public I-ORG Welfare I-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG grant O number O H20150001 B-AWARD The O funders O played O no O role O in O the O design O of O this O study O the O collection O analysis O and O interpretation O of O data O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0200400 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31400073 B-AWARD and O the B-ORG Yunnan I-ORG Natural I-ORG Science I-ORG foundation I-ORG Grant O No. O 2013FB039 B-AWARD from O the O Yunnan O Science O and O Technology O Department O of O China O The O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 41472241 B-AWARD Water B-ORG Conservancy I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG China I-ORG Grant O No. O 2017010 B-AWARD and O the O Postgraduate O Research O O Practice O Innovation O Program O of O Jiangsu O Province O Grant O No. O SJCX19_0153 B-AWARD and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No. O 2019B77514 B-AWARD funded O this O research O This O study O was O supported O by O grant O 81873861 B-AWARD from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O 2022JJ10036 B-AWARD 2021RC3094 B-AWARD from O the O China B-ORG Hunan I-ORG Provincial I-ORG Science/Technology I-ORG Department I-ORG to O Jian O Li, O grant O 2021JJ30464 B-AWARD from O Hunan B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O and O grant O WDCM B-AWARD 2022009 I-AWARD from O the O Open B-ORG Project I-ORG of I-ORG Hubei I-ORG Key I-ORG Laboratory I-ORG of I-ORG Wudang I-ORG Local I-ORG Chinese I-ORG Medicine I-ORG Research I-ORG Hubei O University O of O Medicine O to O Xiaojun O Tao O This O work O was O supported O by O the O Jérôme B-ORG Lejeune I-ORG Foundation I-ORG 2074 O to O F.D.R O the O RETT B-ORG Italian I-ORG Association I-ORG AIRETT I-ORG National O Grant O 2022 B-AWARD to O F.D.R O Project O PON/MISE B-AWARD 2014–2020 I-AWARD FESR I-AWARD F/050011/01-02/X32 O Italy O Italian B-ORG Ministry I-ORG of I-ORG Health I-ORG “Ricerca I-ORG Corrente” I-ORG This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Number O 81601803 B-AWARD Young B-ORG Scientists I-ORG Fund I-ORG of I-ORG Xiangya I-ORG Hospital I-ORG Grant O Number O 2014Q05 B-AWARD and O Xiangya B-ORG Sinobioway I-ORG Health I-ORG Research I-ORG Fund I-ORG Grant O Number O xywm2015I11 B-AWARD National B-ORG Institutes I-ORG of I-ORG Health I-ORG R01-HG007112-01 O U01-NS036695 B-AWARD R01-DK118062 B-AWARD National B-ORG Aeronautics I-ORG and I-ORG Space I-ORG Administration I-ORG NNX16A069A O and O the O National B-ORG Cancer I-ORG Institute I-ORG P30-CA12197 O Funding O for O open O access O charge O Wake O Forest O School O of O Medicine O Institutional O Funds O This O research O was O funded O by O AMINOVITA B-ORG S.L I-ORG PRJ201803388 O Additional O support O was O given O by O Junta B-ORG de I-ORG Andalucía I-ORG grant O numbers O 2017/CTS-657 B-AWARD 2019/CTS-657 B-AWARD 2021/CTS-657 B-AWARD and O the O University B-ORG of I-ORG Seville I-ORG through I-ORG the I-ORG “VI I-ORG Plan I-ORG Propio I-ORG de I-ORG Investigación I-ORG y I-ORG Transferencia” I-ORG grant O numbers O VIPPIT-2019-I.5 B-AWARD VIPPIT-2020-I.5 B-AWARD VIPPIT-2021-I.5 B-AWARD Alexis O E. O Medina-Valmaseda O was O supported O by O a O PhD O scholarship O No. O 666383 B-AWARD from O CONACyT B-ORG Paul O Blanchon O was O funded O by O the O Mexican B-ORG Council I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG CONACyT O A1-S-18879 B-AWARD and O the O Universidad B-ORG Nacional I-ORG Autónoma I-ORG de I-ORG México I-ORG DGAPA/PAPIIT O RN214819 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O paper O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 81503287 B-AWARD 81430094 B-AWARD 81373942 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Beijing I-ORG Municipality I-ORG Grant O No. O 7144222 B-AWARD and O Doctoral B-ORG Program I-ORG Foundation I-ORG of I-ORG Institutions I-ORG of I-ORG Higher I-ORG Education I-ORG of I-ORG China I-ORG Grant O No. O 20130013120002 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 31701901 B-AWARD National O Key O R O O D O Program O of O China O grant O number O 2017YFD0202000 O Provincial B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian O grant O number O 2016J01122 B-AWARD Research B-ORG Project I-ORG of I-ORG FAAS O grant O number O AB2017-3 B-AWARD and I-AWARD AC2017-4 O and O Youth O Talent O Plan O of O FAAS O grant O number O YC2016-3 B-AWARD This O work O was O financially O supported O by O the B-ORG China I-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-48 O China-ASEAN B-ORG Maritime I-ORG Cooperation I-ORG Fund O China-ASEAN O Center O for O Joint O Research O and O Promotion O of O Marine O Aquaculture O Technology O Guangdong B-ORG MEPP I-ORG Fund I-ORG NO.GDOE O 2019 I-AWARD A21 O the B-ORG Guangzhou I-ORG Science I-ORG Technology I-ORG and I-ORG Innovation I-ORG Commission I-ORG Project I-ORG 201510010071 O the B-ORG Guangdong I-ORG Ocean I-ORG and I-ORG Fishery I-ORG Bureau I-ORG Project I-ORG 20164200042090023 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 41471323 B-AWARD 91746206,41661086 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O Nos O 2017YFB0503601 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Development I-ORG Project I-ORG of I-ORG Guizhou I-ORG Province I-ORG Tobacco I-ORG Corporation I-ORG of I-ORG China I-ORG National I-ORG Tobacco I-ORG Corporation I-ORG Contract O No. O 201407 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Industry-University-Research B-ORG in I-ORG Hefei I-ORG University I-ORG of I-ORG Technology I-ORG XC2016JZBZ03 B-AWARD Dr O Shaohua O Yang O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG JZ2017HGTA0228 B-AWARD Dr O Shaohua O Yang O the B-ORG innovation I-ORG Project I-ORG for I-ORG College I-ORG Students I-ORG 2017CXCYS235 B-AWARD Dr O Shaohua O Yang O Wanjiang B-ORG Institute I-ORG of I-ORG Poultry I-ORG Technology I-ORG XC2015AKKG002 B-AWARD Dr O Shaohua O Yang O the B-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG of I-ORG AnHui I-ORG XC2015XKKJ02 B-AWARD XC2015AKKG003 B-AWARD Dr O Shaohua O Yang O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O partly O supported O by O American B-ORG Cancer I-ORG Society I-ORG Research O Scholar O Grant O RSG-18-221-01-MPC O and O National B-ORG Institute I-ORG of I-ORG Health I-ORG grants O R01DE028331 B-AWARD and O R01AI132554 B-AWARD LRC O was O supported O by O NSF B-ORG Bridge I-ORG to O Doctorate O fellowship O number O 1500579 B-AWARD and O NIH-NIDCR B-ORG training O grant O T90DE021990 B-AWARD This O work O was O supported O by O grants O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG project O ID: O 31970010 B-AWARD 31961143010 O the B-ORG Beijing I-ORG Innovative I-ORG Consortium I-ORG of I-ORG Agriculture I-ORG Research I-ORG System I-ORG project O ID: O BAIC05-2019 B-AWARD the B-ORG Biodiversity I-ORG Survey I-ORG and I-ORG Assessment I-ORG Project I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Ecology I-ORG and I-ORG Environment I-ORG China I-ORG project O ID: O 2019HJ2096001006 B-AWARD and O Precise B-ORG Breeding I-ORG and I-ORG Directional I-ORG Development I-ORG of I-ORG Important I-ORG Edible I-ORG Fungi I-ORG Germplasm I-ORG Henan I-ORG Province I-ORG China I-ORG project O ID:221111110600 O This O work O was O supported O by O Southwest B-ORG Minzu I-ORG University I-ORG Research I-ORG Startup I-ORG Funds I-ORG 16011211013/RQD202100 O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Southwest O Minzu O University O 2021115 O 3300222222 B-AWARD 3300223042 B-AWARD and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2022NSFSC0073 O This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81970925 O 81670983 B-AWARD and O 81800956 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017A030308011 O and O 2018A030310330 B-AWARD and O Guangdong B-ORG Financial I-ORG Fund I-ORG for I-ORG High-Caliber I-ORG Hospital I-ORG Construction I-ORG 174-2018-XMZC-0001-03-0125/D-08 O The O authors O gratefully O acknowledge O the O financial O support O provided O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Tianjin I-ORG grant O numbers O 17JCQNJC03000 B-AWARD 18JCQNJC72600 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 11702187 B-AWARD 11502163 B-AWARD Research B-ORG Project I-ORG of I-ORG Tianjin I-ORG Municipal I-ORG Education I-ORG Committee I-ORG grant O number O 2017ZD05 B-AWARD and O Program O for O Innovative O Research O Team O at O the O University O of O Tianjin O TD13-5043 O This O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81302197 O the O Changzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG CE20165048 O the O Changzhou B-ORG High-Level I-ORG Medical I-ORG Talents I-ORG Training I-ORG Project I-ORG 2016CZBJ006 O and O the O Changzhou B-ORG Municipal I-ORG Commissions I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Major I-ORG Scientific I-ORG and I-ORG Technological I-ORG Project I-ORG ZD201620 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 21572091 B-AWARD We O also O thank O the O Science B-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2020JDRC0021 O and O the O Key B-ORG Research I-ORG Project I-ORG of I-ORG Sichuan I-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG 2020YFS0489 O This O research O was O funded O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province O China O ZR2022MH115 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81290342 O 81301479 B-AWARD 82202593 B-AWARD the B-ORG United I-ORG States I-ORG National I-ORG Institutes I-ORG of I-ORG Health I-ORG U01 I-ORG AI151810 O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2021YFC2301102 O and O the B-ORG key I-ORG R&D I-ORG projects I-ORG in I-ORG Zibo I-ORG city I-ORG 2020kj100011 O This O research O was O funded O by O the O Ministry B-ORG of I-ORG Education I-ORG Youth I-ORG and I-ORG Sports I-ORG of I-ORG the I-ORG Czech I-ORG Republic I-ORG “S” O grant O the O National B-ORG Agency I-ORG for I-ORG Agricultural I-ORG Research I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Agriculture I-ORG of I-ORG the I-ORG Czech I-ORG Republic I-ORG grant O n. O QK21010123 B-AWARD and O the O Cultural B-ORG and I-ORG Educational I-ORG Grant I-ORG Agency I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG Science I-ORG Research I-ORG and I-ORG Sport I-ORG of I-ORG the I-ORG Slovak I-ORG Republic I-ORG Project O No. O 002PU-4/2021 B-AWARD This O work O was O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2018YFC1313200 B-AWARD Shandong B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG No. O 2016CYJS01A03 B-AWARD and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81472813 B-AWARD and O 81871895 B-AWARD This O study O was O supported O by O the O Hungarian B-ORG Human I-ORG Resources I-ORG Development I-ORG Operational I-ORG Program I-ORG EFOP-3.6.2-16-2017-00006 O and O by O the O Hungarian O National O Research O Development O and O Innovation O Fund O NKFIH O K-125161 O Additional O support O was O received O from O an O Economic B-ORG Development I-ORG and I-ORG Innovation I-ORG Operative I-ORG Program I-ORG Grant O GINOP O 2.3.2-15 I-AWARD 2016-00048 O and O an O Institutional B-ORG Developments I-ORG for I-ORG Enhancing I-ORG Intelligent I-ORG Specialization I-ORG Grant O EFOP-3.6.1-16-2016-00022 O from O the O National B-ORG Research I-ORG Development I-ORG and I-ORG Innovation I-ORG Office I-ORG This O project O was O funded O by O Sao B-ORG Paulo I-ORG Research I-ORG Foundation I-ORG FAPESP O 2013/19610-3 O Adriano O Carafini’s O scholarship O was O provided O by O the O Foundation O for O Research B-ORG Support I-ORG of I-ORG State I-ORG of I-ORG Goiás I-ORG FAPEG I-ORG Brazil I-ORG Process O 201710267000687 B-AWARD Isabel O Sacco O and O Marcus O Vieira O are O fellows O of O the O National B-ORG Council I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Development I-ORG CNPq I-ORG Brazil I-ORG Process O 304124/2018-4 B-AWARD and O 306205/2017-3 B-AWARD respectively O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O a O grant O from O The O Cross-Cutting B-AWARD Initiative I-AWARD at O the O Earth B-ORG Institute I-ORG Columbia I-ORG University O by O the O City B-ORG of I-ORG New I-ORG York I-ORG tax B-AWARD levy I-AWARD funds O and O by O the O Cooperative O Agreement O Number O 5 B-AWARD NUE1EH001325-02 O funded O by O the O Centers B-ORG for I-ORG Disease I-ORG Control I-ORG and I-ORG Prevention O Its O contents O are O solely O the O responsibility O of O the O authors O and O do O not O necessarily O represent O the O official O views O of O the O Centers O for O Disease O Control O and O Prevention O or O the O Department O of O Health O and O Human O Services O The O ACTIVE O Cognitive O Training O Trial O was O supported O by O grants O from O the O National O Institutes O of O Health O to O six O field O sites O and O the O coordinating O center O including O Hebrew B-ORG Senior-Life I-ORG Boston I-ORG NR04507 O the O Indiana B-ORG University I-ORG School I-ORG of I-ORG Medicine I-ORG NR04508 O the O Johns B-ORG Hopkins I-ORG University I-ORG AG014260 O the O New B-ORG England I-ORG Research I-ORG Institutes I-ORG AG014282 O the O Pennsylvania B-ORG State I-ORG University I-ORG AG14263 O the O University B-ORG of I-ORG Alabama I-ORG at I-ORG Birmingham I-ORG AG14289 O and O the O University B-ORG of I-ORG Florida I-ORG AG014276 O Briana O Sprague O also O received O additional O support O for O this O research O from O the O Indiana O University O Health—Indiana O University O School O of O Medicine O Strategic O Research O Initiative O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 41871140 B-AWARD and O 41801306 B-AWARD Research B-ORG Grants I-ORG Council I-ORG of I-ORG the I-ORG Hong I-ORG Kong I-ORG SAR I-ORG China I-ORG project O number O CityU11612615 B-AWARD and O CityU11666716 B-AWARD and O the O Innovative B-ORG Research I-ORG and I-ORG Development I-ORG Team I-ORG Introduction I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG awarded I-ORG Grant O 2017ZT07X355 B-AWARD to O the O corresponding O author O Y. O Liu O This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2017YFC0805100 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 51505002 B-AWARD Anhui B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No.1708085QE107 O and O the O Major O Program O of O Natural O Science O Research O of O Higher O Education O in O Anhui O Province O China O Grant O No. O KJ2018ZD005 B-AWARD This O research O was O founded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 32102116 B-AWARD the O Major B-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Shandong I-ORG Province O China O Grant O No. O 2022CXGC010605 B-AWARD and O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG of I-ORG MOF I-ORG and I-ORG MARA I-ORG CARS-29 O The O study O was O supported O by O grants O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81370456 O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2014A030311015 O 2014KZDXM041 O the B-ORG Yangfan I-ORG Training I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG 4YF16006G O the B-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Dongguan I-ORG City I-ORG 2015108101015 O 2013108101057 O and O the O Foundation B-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Climbing I-ORG Program I-ORG in I-ORG College I-ORG Students I-ORG of I-ORG Guangdong I-ORG Province I-ORG PDJH2016b0217 O This O work O was O supported O by O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences,http://dx.doi.org/10.13039/100000057 O 1R01 B-AWARD GM120485 O to O Dr O Terry O L. O Vanden O Hoek O National B-ORG Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute,http://dx.doi.org/10.13039/100000050 O K08-HL-091184 B-AWARD to O Dr. O David O G. O Beiser O and O National B-ORG Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute O 1R01HL147031-01 B-AWARD to O Dr O Terry O L. O Vanden O Hoek O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81803443 O 81903551 B-AWARD the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG LQ19H300001 O the B-ORG Wenzhou I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG Y20180180 O Y20180208 B-AWARD Y20190177 B-AWARD ZY2019007 B-AWARD and O the O Special O Project O for O Significant B-ORG New I-ORG Drug I-ORG Research I-ORG and I-ORG Development I-ORG in I-ORG the I-ORG Major I-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG of I-ORG China I-ORG 2020ZX09201002 O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 41461060 B-AWARD Jiangxi B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Funds I-ORG No.20161BBI90041 O and O Jiangxi B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Funds I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholar I-ORG No.20162BC23055 O This O work O was O funded O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31660393 B-AWARD Youth B-ORG Science I-ORG Foundation I-ORG of I-ORG Guizhou I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG [2018]02 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guizhou I-ORG Province I-ORG [2016]1147 B-AWARD and O Construction B-ORG of I-ORG Innovation I-ORG Platform I-ORG for I-ORG Germplasm I-ORG Resources I-ORG of I-ORG Upland I-ORG Food I-ORG Crops I-ORG in I-ORG Guizhou I-ORG Province I-ORG QKZYD B-AWARD 2018]4003 I-AWARD This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0501905 O “Strategic O Priority O Research O Program” O of O the O Chinese B-ORG Academy I-ORG of I-ORG Sciences O Grant O No. O XDA20050104 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Qinghai I-ORG China I-ORG 2019-SF-149,2019-SF-153 O and O the O Qinghai B-ORG Innovation I-ORG Platform I-ORG Construction I-ORG Project I-ORG 2017-ZJ-Y20 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81372072 B-AWARD and I-AWARD 81671918 O Zhejiang B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG China I-ORG No. O 2016C33134 B-AWARD and O Zhejiang B-ORG Provincial I-ORG Medical I-ORG and I-ORG Healthy I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 2016KYB103 B-AWARD and I-AWARD 2016KYB093 O The O OSHI O study O and O SP, O LMcD O SH O and O PF O are O funded O by O the O UK O Medical B-ORG Research I-ORG Council I-ORG and O the O Scottish B-ORG Government I-ORG Chief I-ORG Scientist I-ORG Office O at O the O MRC/CSO O Social O and O Public O Health O Sciences O Unit O University O of O Glasgow O MC_UU_12017/11 O SPHSU B-AWARD 11; O MC_UU_12017/12 B-AWARD SPHSU12 B-AWARD MC_UU_12017/15 B-AWARD SPHSU15 B-AWARD MC_UU_12017/2 B-AWARD MC_UU_12017/6 B-AWARD SP O was O funded O by O a O UK B-ORG Medical I-ORG Research I-ORG Council I-ORG studentship I-ORG 1408655 O The O DeMaSH O study O was O funded O by O a O Scottish O Government O Chief O Scientist O Office O grant O CZH/4/925 O The O funders O had O no O role O in O the O preparation O or O submission O of O the O manuscript O and O the O views O expressed O are O those O of O the O authors O alone O This O work O has O been O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG to O X.H.Z O 61602201 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG to O H.Y.Z O 2662017PY115 O and O X.H.Z O 2662018PY023 O and O the O National B-ORG Instrumentaion I-ORG Program I-ORG 2013YQ19046707 O Shenzhen B-ORG Science I-ORG I-ORG Technology I-ORG Program I-ORG JCYJ20151029154245758 O CKFW2016082915204709 O to O J.H O X. O The O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O no. O 31371381 B-AWARD supported O the O design O of O the O study O and O writing O the O manuscript O the O Henan B-ORG Provincial I-ORG Scientific I-ORG and I-ORG technological I-ORG research I-ORG project I-ORG Grant O nos O 182102110084 B-AWARD and O 162102110046 B-AWARD supported O the O sample O collection O and O analysis O respectively O and O the B-ORG program I-ORG for I-ORG Innovative I-ORG Research I-ORG Team I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG in I-ORG University I-ORG of I-ORG Henan I-ORG Province I-ORG No. O 20IRTSTHN024 B-AWARD and O Nanyang B-ORG Normal I-ORG University I-ORG CN) O Grant O no. O 15081 B-AWARD supported O interpretation O of O data O in O this O study O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32172487 O and O 31801786 B-AWARD the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG of I-ORG MOF I-ORG and I-ORG MARA I-ORG CARS-15-19 O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Hebei I-ORG Province I-ORG 22326509D O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG Province I-ORG C2021301030 O and O HAAFS B-ORG Agriculture I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG 2022KJCXZX-ZBS-1 O This O study O was O funded O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0400601 O and O the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 863 O Program O 2010AA023004 O The O work O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 22074143 O and O 21934005 B-AWARD This O study O was O supported O by O grants O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG no. O 2018YFC1003102 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG nos O 82071716 B-AWARD and O 81771588 B-AWARD the O Guangdong B-ORG Medical I-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Fund I-ORG no. O A2020225 B-AWARD and O the O Guangzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG no. O 201804020087 B-AWARD This O work O was O supported O by O the O Innovative B-ORG Research I-ORG Groups I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 81621003 B-AWARD National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG no. O 2013CB933903 B-AWARD Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG no. O 2019JDRC0103 B-AWARD and O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Funded I-ORG Project I-ORG no. O 2015M572475 B-AWARD This O work O was O supported O by O grants O from O the O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG BB/K009303/1 O BB/N008820/1 B-AWARD and O the O Leverhulme B-ORG Trust I-ORG RPG-2014-267 O APG O is O a O Royal B-ORG Society I-ORG Wolfson O Research O Merit O Award O Holder O WM170036 O This O work O has O been O supported O by O the O following O research O grants O BIO2014-60305R B-AWARD from O the O Spanish O Ministerio O de O Economía O y O Competitividad O MINECO;http://www.mineco.gob.es O to O LAF O LCCM_P59474 B-AWARD Wellcome B-ORG Trust I-ORG Investigator O grant O https://wellcome.ac.uk O to O GF; O MR/J002062/1 B-AWARD from O Medical B-ORG Research I-ORG Council I-ORG MRC;https://www.mrc.ac.uk O to O SS. O MCM O was O supported O by O a O pre-doctoral O contract O from O Consejo B-ORG Superior I-ORG de I-ORG Investigaciones I-ORG Científicas I-ORG CSIC;http://www.csic.es O This O work O was O also O supported O by O PhD O studentships O from O the O Faculty O of O Medicine O and O Health O University O of O East O Anglia O ADSW;https://www.uea.ac.uk O and O the O BBSRC O SJE;http://www.bbsrc.ac.uk/skills/investing-doctoral-training/dtp O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG China I-ORG No.2017ZX09304025 O Xiujuan O Qu O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Liaoning I-ORG Province I-ORG No.2018225060 O Xiaofang O Che O Science B-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG of I-ORG Liaoning I-ORG Province I-ORG No.2016007010 O Yunpeng O Liu O This O study O was O supported O by O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Fujian I-ORG Province I-ORG no. O 2018N5002 B-AWARD Forestry B-ORG Science I-ORG Research I-ORG Project I-ORG of I-ORG Fujian I-ORG Forestry I-ORG Department I-ORG no. O Minlinke B-AWARD 2017 I-AWARD 03 O Major B-ORG Scientific I-ORG and I-ORG Technological I-ORG Special I-ORG Project I-ORG of I-ORG Fujian I-ORG Province I-ORG no. O 2017NZ0003-1-6 B-AWARD Author O MMS O was O supported O by O National B-ORG Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases I-ORG R01AI147870-01A1 B-AWARD and O by O the O U.S B-ORG Department I-ORG of I-ORG Veterans I-ORG Affairs I-ORG Merit O Award O IBX004525-01A2 B-AWARD and I-AWARD IBX005469A O Author O AH O was O supported O by O Centers B-ORG for I-ORG Disease I-ORG Control I-ORG and I-ORG Prevention I-ORG US)U01CK000556-02-01 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O The B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0908500 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81573438 O and O 81773741 B-AWARD Three-year B-ORG Action I-ORG Plan I-ORG for I-ORG Promoting I-ORG Clinical I-ORG Skills I-ORG and I-ORG Innovation I-ORG in I-ORG Municipal I-ORG Hospitals I-ORG 16CR4025A O This O project O and O publication O are O supported O by O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health I-ORG NIMH O grant O R21MH110691 B-AWARD PI: O ARL O Additionally O the O preparation O of O this O article O was O supported O in O part O by O Institute B-ORG of I-ORG Education I-ORG Sciences I-ORG grant O R305A160114 B-AWARD PI: O ARL O NIMH O grant O K01MH100199 B-AWARD PI: O JL O NIMH O grants O R01MH072961 B-AWARD and O R01MH092950 B-AWARD PI: O GAA O and O National B-ORG Institute I-ORG on I-ORG Drug I-ORG Abuse I-ORG NIDA O grant O R01DA038466 B-AWARD PI: O GAA O The O content O in O this O article O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O National O Institutes O of O Health O or O Institute O of O Education O Sciences O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 61904167 B-AWARD and O 21707128 B-AWARD GDAS O Project O of O Science O and O Technology O Development O grant O number O 2020GDASYL-20200102006 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O grant O number O 2019A151501208 B-AWARD Funding O of O Guangdong O Provincial O Key O Laboratory O of O Emergency O Test O for O Dangerous O Chemicals O grant O number O KF2018001 O Q. O L. O acknowledges O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2020M672638 B-AWARD for O financial O support O The O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2020YFE0203200 O the O Second B-ORG Tibetan I-ORG Plateau I-ORG Scientific I-ORG Expedition I-ORG and I-ORG Research I-ORG Program O STEP O 2019QZKK0301 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31600357 O This O work O was O supported O by O the O National B-ORG Undergraduate I-ORG Training I-ORG Program I-ORG for I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Grant O No. O 201810373111 B-AWARD Youth B-ORG Project I-ORG of I-ORG Anhui I-ORG Natural I-ORG Science I-ORG Foundation I-ORG 1908085QC94 O general O Project O of O Anhui O Natural O Science O Foundation O 1908085MC86 O and O Key B-ORG Program I-ORG of I-ORG Anhui I-ORG Natural I-ORG Science I-ORG Research I-ORG Projects I-ORG KJ2019A0958 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O Chinese B-ORG Ministry I-ORG of I-ORG Education’s I-ORG Humanities I-ORG and I-ORG Social I-ORG Science I-ORG Research I-ORG Project I-ORG Grant O No. O 13YJA190015 B-AWARD in O the O design O of O the O study O This O study O was O also O supported O by O Education B-ORG Reform I-ORG Project I-ORG of I-ORG General I-ORG Colleges I-ORG and I-ORG Universities I-ORG in I-ORG Hunan I-ORG Province I-ORG Grant O No. O 2017jy77 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31671144 B-AWARD Shanghai B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG Grant O No. O 2018SHZDZX01 B-AWARD in O data O collection O and O analysis O Besides O the O Hunan B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 2019JJ40362 B-AWARD played O a O vital O role O in O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O Science B-ORG Foundation I-ORG Ireland I-ORG 08/IN.I/B1889;12/IP/1492 B-AWARD to O G.L O I.P.I O and O J.F.A O 13/SIRG/2144 B-AWARD to O R.I.D O and O 12/IA/1335 B-AWARD to O P.V.B O Health B-ORG Research I-ORG Board I-ORG PhD/2007/04 B-AWARD to O I.T O and O K.A.D O Russian B-ORG Science I-ORG Foundation I-ORG 14-14-00127 B-AWARD to O D.E.A O Funding O for O open O access O charge O Health O Research O Board O PhD/2007/04 O This O work O was O financially O supported O by O the O Reform B-ORG project I-ORG of I-ORG review I-ORG and I-ORG approval I-ORG system I-ORG of I-ORG pharmaceutical I-ORG medical I-ORG instruments I-ORG in I-ORG Chinese I-ORG Pharmacopoeia I-ORG Commission I-ORG ZG2016-1 O The B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC1700701 O and O Key B-ORG fields I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG traditional I-ORG Chinese I-ORG Medicine I-ORG ZZ10-27 O This O study O was O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG Grant O Number O 2017J01197 B-AWARD the B-ORG Joint I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG Innovative I-ORG Research I-ORG Project I-ORG Grant O Number O 2017Y9093 B-AWARD Foundation B-ORG of I-ORG Fujian I-ORG Provincial I-ORG Department I-ORG Of I-ORG Finance I-ORG Grant O Number O 2018B011 B-AWARD Startup B-ORG Fund I-ORG for I-ORG scientific I-ORG research I-ORG Fujian I-ORG Medical I-ORG University I-ORG Grant O Number O 2017XQ2041 B-AWARD and O the B-ORG Youth I-ORG Foundation I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG Fujian I-ORG Province I-ORG China I-ORG Grant O Number O 2018-1-51 B-AWARD This O work O was O financially O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31671837 B-AWARD and O supported O the B-ORG Training I-ORG Plan I-ORG for I-ORG the I-ORG Main I-ORG Subject I-ORG of I-ORG Academic I-ORG Leaders I-ORG of I-ORG Jiangxi I-ORG Province I-ORG No. O 20172BCB22006 B-AWARD and O also O supported O the B-ORG Research I-ORG Project I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Food I-ORG Science I-ORG and I-ORG Technology I-ORG No.SKLF-ZZB-201924 O This O study O was O supported O by O the O Jiangsu B-ORG Youth I-ORG Medical I-ORG Talents I-ORG Project I-ORG QNRC2016310 O Changzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG CJ20160004 O and O the O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Wujin I-ORG WS201603 O This O study O was O supported O by O Alzheimer’s B-ORG Association I-ORG AARG B-AWARD 37102 I-AWARD S.R O NIH B-ORG K08-NS099474-1 B-AWARD S.R O NS-091201 B-AWARD M.Y O NS-079331 B-AWARD M.Y O and O VA B-ORG MERIT I-ORG Award I-ORG IO1BX003441 B-AWARD M.Y O This O study O was O supported O in O part O by O the O Emory O Flow O Cytometry O Core O EFCC O one O of O the O Emory O Integrated O Core O Facilities O EICF O and O is O subsidized O by O the O Emory O University O School O of O Medicine O Additional O support O was O provided O by O the O Georgia B-ORG Clinical I-ORG I-ORG Translational I-ORG Science I-ORG Alliance I-ORG of I-ORG the I-ORG NIH I-ORG under O Award O Number O UL1TR002378 B-AWARD The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O reflect O the O official O views O of O the O NIH O The O authors O wish O to O thank O Shandong B-ORG Provincial I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG Major O Scientific O and O Technological O Innovation O Project O No. B-AWARD 2022CXGC010505 O Key B-ORG Project I-ORG of I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG No. O ZR2020KE016 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51773188 O This O work O was O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O Number O 2016YFA0602703 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Number O 41671396 B-AWARD and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG China I-ORG Grant O Number O 19ZR1415200 B-AWARD This O study O was O supported O by O the O National B-ORG Social I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 17ZDA078 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 71774030 B-AWARD It O was O also O the O Program B-ORG of I-ORG the I-ORG Key I-ORG Discipline I-ORG in I-ORG Shanghai I-ORG No. O ZDXK201506 B-AWARD In O addition O Qi O Zhang O was O supported O by O the O 111 B-ORG Project O grant O number O B16031 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O We O are O grateful O to O our O DP O participants O for O their O involvement O in O the O study O Funding O was O provided O byESRC(RES-061-23-0040 O to O B.D O by O theDeutsche O Forschungsgemeinschaft(DFG O MO I-AWARD 2397/1-1 O to O S.M O and O by O theFundação O para I-ORG a I-ORG Ciência I-ORG e I-ORG a I-ORG Tecnologia I-ORG FCT)(SFRH/BD/22580/2005 O to O L.G O TheWellcome O Trust(079866/Z/06/Z O to O Z.N O N.F O S.M O covered O scanning O costs O This O work O was O funded O by O the O U.S B-ORG National I-ORG Institutes I-ORG of I-ORG Health I-ORG Grant O AI077538 B-AWARD to O R.D O B.S.M O is O supported O by O the O UKRI B-ORG Grand I-ORG Challenges I-ORG Research I-ORG Fund I-ORG A O Global O Network O for O Neglected O Tropical O Diseases O grant O MR/P027989/1 B-AWARD L.P.C O was O supported O by O the O U.S B-ORG National I-ORG Institute I-ORG of I-ORG Health I-ORG Training O Grant O T32 B-AWARD AI060546 O This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2021YFD1300100 B-AWARD Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG China I-ORG Grant O No. O 202201010507 O and O the O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangdong I-ORG province I-ORG China I-ORG 2020B1212060060 O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 61803043 B-AWARD Department B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Jilin I-ORG Province I-ORG grant O number O 20180520224JH B-AWARD and O Education B-ORG Department I-ORG of I-ORG Jilin I-ORG Province I-ORG grant O number O JJKH20181043KJ B-AWARD This O research O was O supported O by O the O Leading O Foreign O Research O Institute O Recruitment O Program O through O the O National O Foundation O of O Korea O NRF O funded O by O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG ICT I-ORG MSIT O NRF-2018K1A4A3A02060572 O a O grant O of O the O Korea O Health O Technology O R&D O Project O through O the O Korea O Health O Industry O Development O Institute O KHIDI O funded O by O the O Ministry B-ORG of I-ORG Health I-ORG I-ORG Welfare O Republic O of O Korea O Grant O No. O HI15C1524 B-AWARD The O design O of O the O study O and O material O supplements O were O supported O by O Basic O Science O Research O Program O through O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O funded O by O the O Ministry O of O Education O 2017R1D1A1B03030060 O and O the O interpretation O of O data O and O writing O editing O service O of O this O manuscript O were O supported O by O a O grant O of O the O Korea O Health O Technology O R&D O Project O through O the O Korea O Health O Industry O Development O Institute O KHIDI O funded O by O the O Ministry O of O Health O O Welfare O Republic O of O Korea O Grant O No. O HI15C1524 O This O research O was O funded O by O the O Junta B-ORG de I-ORG Andalucía I-ORG CTS O 164 O by O the O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III I-ORG ISCIII O PI19.01058 O and O by O the O Spanish B-ORG Ministry I-ORG of I-ORG Economy I-ORG and I-ORG Competitiveness I-ORG AGL2015-67995-C3-3-R O with O funds O from O the O European O Commission O FEDER/ERDF O The O CIBER-EHD O is O funded O by O the O Instituto O de O Salud O Carlos O III O J.A O Molina-Tijeras O recipient O of O pFIS O FI20/00159 O Instituto O de O Salud O Carlos O III O Programa O de O Doctorado O Nutricion O A.J O Ruiz-Malagón O recipient O of O Formación O de O Profesorado O Universitario O Program O Universidad O de O Granada O Programa O de O Doctorado O Medicina O Clínica O y O Salud O Pública O and O M.J O Rodriguez-Sojo O recipient O of O i-pFI O IFI21/00030 O Instituto O de O Salud O Carlos O III O Programa O de O Doctorado O Biomedicina O are O predoctoral O fellows O T. O Vezza O is O the O recipient O of O Miguel O Servet O contract O CP22/00153 O from O the O Instituto O de O Salud O Carlos O III O This O work O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Project O No. O 31772547 B-AWARD and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG under I-ORG Grant I-ORG Project O No. O 2021JCKT-06 B-AWARD and O College B-ORG Students I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Training I-ORG Program I-ORG of I-ORG Jilin I-ORG University I-ORG Project O Nos O S202210183609 B-AWARD X202210183635 O The O authors O would O like O to O thank O Fundação B-ORG para I-ORG a I-ORG Ciência I-ORG e I-ORG a I-ORG Tecnologia I-ORG FCT O for O funding O the O JM O PhD O scholarship O SFRH/BD/116147/2016 O This O research O was O also O supported O by O national B-ORG funds I-ORG through I-ORG FCT I-ORG within O the O scope O of O UIDB/05748/2020 B-AWARD UIDP/05748/2020 B-AWARD UIDB/50016/2020 B-AWARD and O through O Norte2020—Sistema B-ORG de I-ORG Apoio I-ORG à I-ORG Investigação I-ORG Científica I-ORG e I-ORG Tecnológica I-ORG NORTE-01-0145-FEDER-000041 O This O work O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31601944 B-AWARD Education B-ORG Department I-ORG of I-ORG Sichuan I-ORG 17ZA0300 O and O Applied O Basic O Research O Project O from O Science B-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2021YJ0264 O and O 2020YJ0127 B-AWARD This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61673143 O 31671187 B-AWARD Postdoctoral B-ORG Scientific I-ORG Research I-ORG Developmental I-ORG Fund I-ORG No. O LBH-Q16166 B-AWARD and O the O University B-ORG Nursing I-ORG Program I-ORG for I-ORG Young I-ORG Scholars I-ORG with I-ORG Creative I-ORG Talents I-ORG in I-ORG Heilongjiang I-ORG Province I-ORG UNPYSCT-2017061 O SH O was O supported O by O the O European B-ORG Research I-ORG Council I-ORG grant O agreement O N°647954,https://erc.europa.eu O the O Economic B-ORG and I-ORG Social I-ORG Research I-ORG Council I-ORG ESRC O grant O agreement O N°ES/R010072/1,https://esrc.ukri.org O and O Deutsche B-ORG Forschungsgemeinschaft I-ORG HA O 5622/1-1,https://www.dfg.de O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O paper O This O work O was O financially O supported O by O the O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82072501 O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Leading I-ORG Plan I-ORG of I-ORG High-Tech I-ORG Industry I-ORG in I-ORG Hunan I-ORG Province I-ORG 2020SK2011 O Youth B-ORG Fund I-ORG Project I-ORG of I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG 2020JJ5848 O and O Medical B-ORG Research I-ORG Development I-ORG Fund I-ORG Project I-ORG WS865C O This O study O was O supported O by O grants O from O the B-ORG National I-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2012CB723504 O the B-ORG National I-ORG Major I-ORG New I-ORG Drug I-ORG Discovery I-ORG Grant I-ORG 2013ZX09201020 O the B-ORG National I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 81274128 O and O the B-ORG Program I-ORG for I-ORG Tianjin I-ORG Innovative I-ORG Research I-ORG Team I-ORG in I-ORG University I-ORG TD12-5031 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31872030 O the O Taishan B-ORG Scholar I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG tstp20221135 O the O First-Class B-ORG Grassland I-ORG Science I-ORG Discipline I-ORG Program I-ORG in I-ORG Shandong I-ORG Province I-ORG 1619002 O We O thank O the O National B-ORG Natural I-ORG Science I-ORG Funds I-ORG 81172662 O the O Specialized B-ORG Research I-ORG Fund I-ORG for I-ORG the I-ORG Doctoral I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG 20123706110004 O and O the O Qingdao B-ORG Postdoctoral I-ORG Application I-ORG Research I-ORG Project I-ORG 2015148 O for O the O grants O supporting O the O study O This O work O was O supported O by O the B-ORG National I-ORG Nature I-ORG Foundation I-ORG of I-ORG China I-ORG No.81672184 O Peak B-ORG Talents I-ORG Foundation I-ORG in I-ORG Jiangsu I-ORG Province(2015-WSN-065 O the B-ORG Key I-ORG Program I-ORG of I-ORG Science I-ORG and I-ORG Technique I-ORG Development I-ORG Foundation I-ORG in I-ORG Jiangsu I-ORG Province I-ORG BE2016642 O This O study O has O been O supported O by O grants O from O PRIN-MIUR B-ORG 2011-2014 O Basi O molecolari O dei O processi O di O carcinogenesi O polmonare O caratterizzazione O del O network O trascrizionale O e O di O microRNA O a O valle O delle O vie O di O trasduzione O del O segnale O attive O durante O lo O sviluppo O embrionale O in O cellule O staminali O tumorali O PNR-CNR B-ORG Aging I-ORG Program I-ORG 2012-2014 B-AWARD POR B-ORG Campania I-ORG FSE I-ORG 2007-2013 B-AWARD CREMe O CNR B-ORG Flagship I-ORG Projects I-ORG Epigenomics-EPIGEN O PON I-AWARD 01-02782 I-AWARD Nuove O strategie O nanotecnologiche O per O la O messa O a O punto O di O farmaci O e O presidi O diagnostici O diretti O verso O cellule O cancerose O circolanti O Associazione O Italiana O per O la O Ricerca O sul O Cancro O AIRC O IG B-AWARD 11477 O The O project O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31771128 B-AWARD The O FHS O Internal O Collaboration O Proposals O 2017 O MYRG2016-00052-FHS B-AWARD and I-AWARD MYRG2018-00134-FHS I-AWARD from O the O University B-ORG of I-ORG Macau O and O the O Science B-ORG and I-ORG Technology I-ORG Development I-ORG Fund I-ORG FDCT I-ORG of I-ORG Macao I-ORG 016/2016/A1 O We O are O grateful O to O UM-FHS O and O core O facilities O for O equipment O and O administrative O support O for O this O study O This O work O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O no. O 61306019 B-AWARD the O Henan B-ORG Provincial I-ORG Science I-ORG Found I-ORG Grant O no. O 162300410026 B-AWARD the O Key B-ORG Member I-ORG of I-ORG Young I-ORG Teachers I-ORG Grant O no. O 2016GGJS-019 B-AWARD and O the O Henan O University O Fund O This O work O was O financially O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81773421 O Jiangsu B-ORG Province I-ORG Key I-ORG Research I-ORG and I-ORG Social I-ORG Development I-ORG Program I-ORG BE2015607 O and O the B-ORG Innovation I-ORG Team I-ORG of I-ORG Jiangsu I-ORG Health I-ORG CXTDA O 2017035 O The O funders O had O no O role O in O the O study O design O or O collection O analysis O or O interpretation O of O data O or O in O writing O this O manuscript O The O authors O acknowledge O the O collective O support O granted O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No O 52105196 B-AWARD the O Education B-ORG Department I-ORG of I-ORG Liaoning I-ORG Province I-ORG Grant O No O LJKMZ20220936 B-AWARD and O the O Young B-ORG and I-ORG Middle-aged I-ORG Innovation I-ORG Team I-ORG of I-ORG Shenyang I-ORG Grant O No O RC210343 B-AWARD This O review O was O supported O by O the O Program O of O the O National B-ORG Beef I-ORG Cattle I-ORG and I-ORG Yak I-ORG Industrial I-ORG Technology I-ORG System I-ORG CARS-37 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.31001096 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Henan I-ORG Province I-ORG 162300410145 O and O Project B-ORG of I-ORG Education I-ORG Department I-ORG of I-ORG Henan I-ORG Province I-ORG 16A230022 O This O work O was O supported O by O Grant B-ORG of I-ORG Fuzhou I-ORG General I-ORG Hospital I-ORG Nos O 2014CXTD03 B-AWARD and O 2016Q03 B-AWARD the O Program B-ORG for I-ORG the I-ORG Top I-ORG Young I-ORG Innovative I-ORG Talents I-ORG of I-ORG Fujian I-ORG Province O No. O 2016RCLKC B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81771547 B-AWARD This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61605057 O 61575076 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jilin I-ORG Province I-ORG 20190201190JC O and O Excellent B-ORG Youth I-ORG Foundation I-ORG of I-ORG Jilin I-ORG Province I-ORG 20170520158JH O This O research O was O funded O by O the O Capital’s B-ORG Funds I-ORG for I-ORG Health I-ORG Improvement I-ORG and I-ORG Research I-ORG 2020-1-2041 O Chinese B-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG 2019-I2M-5-029 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81870905 O U20A20358 B-AWARD This O research O was O supported O by O the O Deutsche B-ORG Forschungsgemeinschaft I-ORG DFG O German B-ORG Research I-ORG Foundation O Project-ID O 387509280—SFB1350 B-AWARD and O Project-ID O 509149993—TRR B-AWARD 374 I-AWARD Subproject O C6 O to O I.M.H O The O AugUR O study O was O supported O by O the O German B-ORG Federal I-ORG Ministry I-ORG of I-ORG Education I-ORG and I-ORG Research I-ORG grant O number O BMBF B-AWARD 01ER1206 O BMBF B-AWARD 01ER1507 I-AWARD to O I.M.H O and O by O the O German O Research O Foundation O grant O number O HE B-AWARD 3690/7-1 I-AWARD to O I.M.H O BR B-AWARD 6028/2-1 I-AWARD to O C.B O This O work O was O supported O by O grants O from O the O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq O 465656/2014-5 O Fundação B-ORG de I-ORG Apoio I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG do I-ORG Rio I-ORG de I-ORG Janeiro I-ORG FAPERJ O E26/110.272/2014 O and O DECIT B-ORG Ministério I-ORG da I-ORG Saúde O Brazil O 405036 O This O work O was O funded O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2022YFA1303600 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Chongqing I-ORG cstc2021jcyj-msxmX0298 O cstc2020jcyj-msxmX0764 B-AWARD and O cstc2020jscx-dxwtBX0022 B-AWARD the O 111 B-ORG Project I-ORG No. O D20028 B-AWARD the O Key B-ORG Laboratory I-ORG of I-ORG Molecular I-ORG Biology I-ORG on I-ORG Infectious I-ORG Diseases I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG Chongqing I-ORG Medical I-ORG University I-ORG No. O 202104 B-AWARD and O the O CQMU B-ORG Program I-ORG for I-ORG Youth I-ORG Innovation I-ORG in I-ORG Future I-ORG Medicine I-ORG No. O W0049 B-AWARD This O work O was O supported O by O Wuxi B-ORG Young I-ORG Medical I-ORG Talents I-ORG grant O number O QNRC083 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81701302 B-AWARD Health B-ORG Institute I-ORG of I-ORG Wuxi I-ORG grant O number O Q201301,Q201625 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG of I-ORG China I-ORG grant O number O BK20141121 B-AWARD This O study O was O financially O supported O by O the O Chief B-ORG Scientist I-ORG Office I-ORG CSO O 06/S1103/5 O and O the O Fondo B-ORG de I-ORG Investigación I-ORG Sanitaria I-ORG FIS I-ORG PI08/0320 O Dr. O Ramzi O Lakhdar O was O supported O by O an O ERS B-ORG Long I-ORG Term I-ORG Research I-ORG fellowship I-ORG LTRF O 068-2012 O The O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81671609 O and O 81871290 B-AWARD to O Dr. O Y. O Su; O 81971523 B-AWARD and O 81671604 B-AWARD to O Dr. O F. O Hu O the O Beijing B-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG Z191100006619111 O to O Dr. O Y. O Su O the O Beijing B-ORG Municipal I-ORG Natural I-ORG Science I-ORG Foundation I-ORG 7194329 O to O Dr. O L. O Xu O and O the O Beijing B-ORG Nova I-ORG Program I-ORG Z181100006218044 O to O Dr. O F. O Hu O as O well O as O by O the O Peking B-ORG University I-ORG People’s I-ORG Hospital I-ORG Research I-ORG and I-ORG Development I-ORG Funds I-ORG RDF2019-03 O to O Dr. O F. O Hu O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 81672398 B-AWARD and I-AWARD 81972192 O Jiangsu B-ORG Province I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG BK20150089 O and O Nanjing B-ORG Medical I-ORG Science I-ORG and I-ORG technique I-ORG Development I-ORG Foundation I-ORG Youth O Foundation O Level O 2, O no. O QRX17079 B-AWARD The O study O was O supported O Young B-ORG Medical I-ORG Talent I-ORG of I-ORG Jiangsu I-ORG Province I-ORG QNRC2016229 O Suzhou B-ORG Key I-ORG Diagnosis I-ORG and I-ORG Treatment I-ORG Program I-ORG LCZX201616 O Suzhou B-ORG Key I-ORG Medical I-ORG Center I-ORG for I-ORG Psychiatric I-ORG Diseases I-ORG SZZX201509 O Suzhou B-ORG Municipal I-ORG Sci-Tech I-ORG Bureau I-ORG Program I-ORG SYSD2012125 O Health B-ORG City I-ORG “531” I-ORG action I-ORG plan I-ORG of I-ORG Suzhou I-ORG Municipal I-ORG and I-ORG Suzhou I-ORG Clinical I-ORG Medicine I-ORG Expert I-ORG Team I-ORG SZYJTD201715 O The O funders O had O no O role O in O study O design O data O collection O data O analysis O data O interpretation O and O writing O of O the O manuscript O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O NO.81400360 O 81270195 B-AWARD 8130079 B-AWARD Medical B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG NO.B2014311 O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG NO. O 2014A020212293 B-AWARD This O work O was O funded O by O the B-ORG General I-ORG Program I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG Hubei I-ORG Province I-ORG of I-ORG China I-ORG Grant O No. I-AWARD WJ2017M194 O the B-ORG General I-ORG Program I-ORG of I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG of I-ORG China I-ORG Grant O No. I-AWARD 2017CFB709 O the B-ORG Frontier I-ORG Project I-ORG of I-ORG Application I-ORG Foundation I-ORG of I-ORG Wuhan I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG of I-ORG China I-ORG Grant O No. I-AWARD 2018060401011314 O and O the B-ORG National I-ORG Mega I-ORG Project I-ORG on I-ORG Major I-ORG Infectious I-ORG Disease I-ORG Prevention I-ORG of I-ORG China I-ORG Grant O No. I-AWARD 2017ZX10103005-007-001 O This O work O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O 71571182 B-AWARD in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Youth I-ORG Foundation I-ORG of I-ORG China I-ORG under O Grant O 61603396 B-AWARD in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG and I-ORG the I-ORG Civil I-ORG Aviation I-ORG Grant I-ORG under O Grant O U1633124 B-AWARD and O Grant O U1733102 B-AWARD in O part O by O Shenzhen O Science O and O Technology O Innovation O Committee O under O Grant O ZDSYS20170725140921348 B-AWARD and O in O part O by O the O Air O Traffic O Management O Research O Institute O NTU O and O the O Civil O Aviation O Authority O of O Singapore O under O grant O M4061216.057 B-AWARD This O work O was O supported O by O the B-ORG Application I-ORG Foundation I-ORG Project I-ORG of I-ORG Sichuan I-ORG Provincial I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2019YJ0389 O the B-ORG Technological I-ORG Innovation I-ORG Project I-ORG of I-ORG Chengdu I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG 2018-YF05-00522-SN O the B-ORG Key I-ORG Scientific I-ORG Research I-ORG Fund I-ORG of I-ORG Xihua I-ORG University I-ORG Z1310525 O the B-ORG Graduate I-ORG Student I-ORG Innovation I-ORG Fund I-ORG of I-ORG Xihua I-ORG University I-ORG ycjj2019122 O All O phases O of O this O work O were O supported O by O the O American B-ORG Cancer I-ORG Society I-ORG IRG-82-003-30 O the O National B-ORG Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences I-ORG of O the O National O Institutes O of O Health O UL1TR001086 O and O the O Dartmouth O SYNERGY O Scholars O Award O FSV O was O additionally O supported O by O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG of O the O National O Institutes O of O Health O T32GM008704 O This O work O was O supported O by O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017M620119 O Heilongjiang B-ORG Postdoctoral I-ORG Fund I-ORG LBH-Z17108 O and O the O Scientific B-ORG Research I-ORG Project I-ORG of I-ORG Heilongjiang I-ORG Provincial I-ORG Department I-ORG of I-ORG Health I-ORG Nos O 2013030 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21761142002 O the O Chinese B-ORG Academy I-ORG of I-ORG Science I-ORG XDB31000000 O SAJC201606 I-AWARD and I-AWARD KGFZD-135-17-011 O Biological O Resources O Programme O Chinese O Academy O of O Sciences O KFJ-BRP-008 O and O Yunnan B-ORG Province I-ORG Grant I-ORG 2015HA023 O to O R.L O and O the O National O Natural O Science O Foundation O of O China O 81770464 O the O Chinese O Academy O of O Science O Strategic O Priority I-AWARD Research I-AWARD Program I-AWARD A) I-AWARD XDA12040221 I-AWARD and I-AWARD Youth I-AWARD Innovation I-AWARD Promotion I-AWARD Association I-AWARD 2017432 O and O National O Key O R&D O Program O of O China O 2018YFC2000400 O to O Z.Z O CHR O acknowledges O a O Lefoulon-Delalande O Foundation O fellowship O administered O by O the O Institute O of O France O and O aMedical O Research I-ORG Council I-ORG Skills I-ORG Development I-ORG Fellowship(MR/S015086/1 O This O study O received O financial O support O from O the O French O Government O as O part O of O the O Investments O of O the O Future O program O managed O by O the O National O Research O Agency O ANR O Grant O reference O ANR-10-IAHU-04 O We O acknowledge O PRACE O for O awarding O us O access O to O ARCHER O UK O National O Supercomputing O Service O SAN O acknowledges O support O from O theUK O Engineering I-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council(EP/M012492/1 O NS/A000049/1 B-AWARD and O EP/P01268X/1 B-AWARD theBritish O Heart I-ORG Foundation(PG/15/91/31812 O PG/13/37/30280 B-AWARD and O Kings O Health O Partners O London O National O Institute O for O Health O Research O NIHR O Biomedical O Research O Centre O This O work O was O supported O by O the O Wellcome/EPSRC O Centre O for O Medical O Engineering O WT O 203148/Z/16/Z O and O a O Transatlantic O Network O grant O from O the O Leducq O Foundation O to O NT O and O EV, O Research O Grant O number O 16 O CVD O 02 O The O financial O supports O from O the O National B-ORG Science I-ORG Fund I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG NSFC O Project O No. O 21625602 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O Project O Nos O 21376066 B-AWARD 81503112 I-AWARD 21506049 I-AWARD and I-AWARD 31570054 O and O Hubei B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG for I-ORG Innovative I-ORG Research I-ORG Team I-ORG 2015CFA013 O are O gratefully O acknowledged O Prof O Ya-Jie O Tang O also O thanks O the O National O High O Level O Talents O Special O Support O Plan O “Million O People O Plan” O by O the O Organization O Department O of O the O CPC O Central O Committee O 2014 O Training O Program O for O Top O Talents O in O Hubei O Province O 2013 O and O Training O Program O for O Huanghe O Talents O in O Wuhan O Municipality O 2014 O This O work O was O supported O by O a O grant O from O Major B-ORG State I-ORG Basic I-ORG Research I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 973 O Program O No. O 2014CB542602 B-AWARD the B-ORG Strategic I-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDPB0304 O One O Belt O and O One O Road O International O Science O and O Technology O Cooperation O of O Chinese O Academy O of O Sciences O 153211KYSB20170001 O and O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81761128002 O 81602339 B-AWARD 81621091 B-AWARD 81471960 B-AWARD 81672815 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81271088 B-AWARD 81670926 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG Grant O No. O 15411950303 B-AWARD 14DZ2260300 B-AWARD and O Doctoral B-ORG Innovation I-ORG Fund I-ORG of I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG School I-ORG of I-ORG Medicine I-ORG Grant O No. O BXJ201722 B-AWARD Some O strains O were O provided O by O the O CGC O which O is O funded O by O NIH O Office O of O Research O Infrastructure O Programs O P40 O OD010440 O This O work O was O supported O by O grants O from O the O National B-ORG Institute I-ORG on I-ORG Aging I-ORG of O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG R00AG037621 O and O by O The O Ellison B-ORG Medical I-ORG Foundation I-ORG AG‐NS‐1087‐13 O Research O reported O in O this O publication O was O also O supported O by O an O Institutional O Development O Award O IDeA O from O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medical I-ORG Sciences I-ORG of O the O National O Institutes O of O Health O under O grant O numbers O P20GM0103423 B-AWARD and O P20GM104318 B-AWARD This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 42171418 B-AWARD Key B-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG Hunan I-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG grant O number O 22A0332)and B-AWARD Hunan B-ORG Natural I-ORG Science I-ORG Foundation I-ORG Innovation I-ORG Group I-ORG Project I-ORG grant O number O 2020JJ1003 B-AWARD This O study O was O supported O by O the B-ORG National I-ORG Natural I-ORG Scientific I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No.71503062 O and O China B-ORG Postdoctoral I-ORG Fund I-ORG Grant O No. O 2017M611402 B-AWARD Part O of O this O study O was O also O funded O by O the B-ORG Heilongjiang I-ORG Postdoctoral I-ORG Fund I-ORG Grant O No. O LBH-Z16137 B-AWARD LBH-Z16240 B-AWARD Key B-ORG Lab I-ORG of I-ORG Health I-ORG Technology I-ORG Assessment I-ORG National I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG the I-ORG People’s I-ORG Republic I-ORG of I-ORG China I-ORG Grant O No. O FHTA2017-08 B-AWARD the B-ORG HMU I-ORG Innovation I-ORG Fund I-ORG Grant O No. O 2017RWZX08 B-AWARD the B-ORG Hospital I-ORG Foundation I-ORG of I-ORG the I-ORG First I-ORG Affiliated I-ORG Hospital I-ORG of I-ORG Harbin I-ORG Medial I-ORG University I-ORG Grant O No. O 2015B019 B-AWARD and O the B-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG project O NO. O 2009–230 B-AWARD This O work O was O supported O by O “National O Key I-ORG R&D I-ORG Program I-ORG of I-ORG China” O Grant O No. O 2016YFE0105400 B-AWARD “National O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China” O Grant O No. O 21606132 B-AWARD “Natural O Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province” O Grant O No. O BK20160823 B-AWARD BK20170037 B-AWARD O BK20170832 B-AWARD “The O Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities” O Grant O No. O 30916011202 B-AWARD and O the O Foundation O of O Jiangsu O Specially-Appointed O Professor O This O study O received O funding O from O the B-ORG National I-ORG Key I-ORG Projects I-ORG of I-ORG Research I-ORG and I-ORG Development I-ORG of I-ORG China I-ORG 2016YFC0904600 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81972860 O the B-ORG Capital I-ORG Characteristic I-ORG Clinic I-ORG Project I-ORG Z171100001017116 O and O the B-ORG Medical I-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG of I-ORG China I-ORG B2020065 O The O funders O of O the O study O had O no O role O in O study O design O data O collection O data O analysis O data O interpretation O or O writing O of O the O manuscript O This O study O was O financed O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG No. O 2014BSB01225 B-AWARD Advanced B-ORG Talents I-ORG Foundation I-ORG of I-ORG QAU I-ORG No. O 631328 B-AWARD Scientific B-ORG Research I-ORG Foundation I-ORG for I-ORG the I-ORG Returned I-ORG Overseas I-ORG Chinese I-ORG Scholars I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG No. O 6622315013 B-AWARD This O work O was O supporte O d O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31672651 B-AWARD the B-ORG Chinese I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG through I-ORG the I-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0901400 O The B-ORG Earmarked I-ORG Fund I-ORG for I-ORG Modern I-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG No. O CARS-49 B-AWARD National B-ORG Marine I-ORG Economic I-ORG Development I-ORG Demonstration I-ORG Project I-ORG in I-ORG Xiamen I-ORG No. O 16CZB023SF12 B-AWARD the B-ORG Key I-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG of I-ORG Henan I-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG No. O 20A240002 B-AWARD Research O reported O in O this O publication O was O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG Grant O Number O 1554166 B-AWARD the O National B-ORG Aeronautics I-ORG and I-ORG Space I-ORG Administration I-ORG Grant O Number O NNX15AU64H B-AWARD and O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG Grant O Numbers O P20GM109095 B-AWARD and O P20GM103408 B-AWARD The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O granting O agencies O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81972581 O 81472570 O Shanghai B-ORG Municipal I-ORG Key I-ORG Clinical I-ORG Specialty I-ORG shslczdzk01303 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG 19ZR1452800 O and O Foundation B-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Health I-ORG Commission I-ORG 201940429 O This O study O was O financially O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81372984 O and O the O Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Committee I-ORG of I-ORG Shenzhen I-ORG Municipality I-ORG JCYJ20170817094634747 O awarded O to O JT, O also O grants O from O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2016M602531 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017A030310140 O awarded O to O BYR O This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31470845 O 81430033 B-AWARD and O 31670896 B-AWARD Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG 13JC1404700 O and O Shanghai B-ORG Rising-Star I-ORG Program I-ORG 16QA1403300 O This O research O was O funded O by O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 71872191 B-AWARD the O Chinese B-ORG Ministry I-ORG of I-ORG Education I-ORG grant O number O 18YJA630151 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG grant O number O 2018A030313502 B-AWARD This O work O was O supported O by O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81673450 I-AWARD and O No. O 81373323 O NSFC-Shandong B-ORG Joint I-ORG Fund I-ORG U1606403 O and O the B-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG Project I-ORG Financially I-ORG Supported I-ORG by I-ORG the I-ORG Qingdao I-ORG National I-ORG Laboratory I-ORG for I-ORG Marine I-ORG Science I-ORG and I-ORG Technology I-ORG No.2015ASKJ02 O This O study O was O supported O by O the B-AWARD Chulalongkorn I-AWARD Academic I-AWARD Advancement I-AWARD Into I-AWARD Its I-AWARD 2nd O Century O Project O and O in O part O by O the B-AWARD Faculty I-AWARD Research I-AWARD Grant O Faculty B-ORG of I-ORG Dentistry I-ORG Chulalongkorn B-ORG University O N.N O is O supported O by O the B-AWARD Ratchadapisek I-AWARD Sompote I-AWARD Fund I-AWARD for I-AWARD Postdoctoral I-AWARD Fellowship O Chulalongkorn O University O T.O O was O supported O by O Thailand B-ORG Research I-ORG Fund I-ORG TRF-RSA6180019 O Financial O support O was O provided O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31870389 O Opening B-ORG Foundation I-ORG of I-ORG Key I-ORG Laboratory I-ORG of I-ORG Resource I-ORG Biology I-ORG and I-ORG Biotechnology I-ORG in I-ORG Western I-ORG China I-ORG Northwest I-ORG University I-ORG Ministry I-ORG of I-ORG Education I-ORG ZSK2017002 O and O Natural B-ORG Science I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG Shaanxi I-ORG 2019JM356 O The O funders O provided O funds O for O this O study O including O the O design O of O the O study O the O experimental O work O and O analysis O This O work O was O supported O by O the O National B-ORG Institute I-ORG of I-ORG Nursing I-ORG Research I-ORG R01NR017916 O to O Dr. O Avidan O the O Foundation B-ORG for I-ORG Anesthesia I-ORG Education I-ORG and I-ORG Research I-ORG MRTG08152020 O to O Dr. O Fritz O the O National B-ORG Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences I-ORG KL2TR002346 O to O Dr. O King O the O National B-ORG Science I-ORG Foundation I-ORG 1622678 O to O Dr. O Avidan O and O Dr. O Chen O and O the O Agency B-ORG for I-ORG Healthcare I-ORG Research I-ORG and I-ORG Quality I-ORG R21HS024581 O to O Dr. O Avidan O This O research O was O supported O by O The O CAS B-ORG President’s I-ORG International I-ORG Fellowship I-ORG Initiative I-ORG Grant O 2021PB0040 O Key B-ORG Research I-ORG Program I-ORG of I-ORG Frontier I-ORG Sciences I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG ZDBS-LY-SM009 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Xinjiang I-ORG Uygur I-ORG Autonomous I-ORG Region I-ORG Grant O No. O 2022D01E96 B-AWARD This O work O was O supported O by O the O Ministry B-ORG of I-ORG Science I-ORG Technology I-ORG and I-ORG Innovation I-ORG of I-ORG Malaysia I-ORG MOSTI I-ORG for O the O E-Science O Fund O 02-02-11-SF0125 O UM B-ORG High I-ORG Impact I-ORG Research I-ORG Grants I-ORG UM-MOHE O HIR O Grant O UM.C/625/1/HIR/MOHE/CHAN/01 B-AWARD no. O A000001-50001 B-AWARD UM-MOHE O HIR O Grant O UM.C/625/1/HIR/MOHE/CHAN/14/1 B-AWARD H-50001-A000027 B-AWARD and O Universiti B-ORG Tunku I-ORG Abdul I-ORG Rahman I-ORG Research I-ORG Fund I-ORG UTARRF I-ORG A6200/A23 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O National O Natural O Science O Foundation O Grant O no. O 81400136 B-AWARD National O Natural O Science O Foundation O Grant O no. O 81670159 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81830005 O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG Grant O no. O CIFMS B-AWARD 2016-I2M-3-004 O CIFMS O 2016-I2M-1-001 O The B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG for I-ORG Precision I-ORG Medicine I-ORG Grant O no. O 2017YFC0909800 B-AWARD The O funds O mentioned O were O used O for O reagents O and O consumable O materials O purchasing O and O language O editing O of O the O manuscript O The O funders O had O no O role O in O study O design O data O collection O and O analysis O or O decision O to O publish O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Institutes I-ORG of I-ORG Health O grant O number O R01HD098154 B-AWARD the O Department B-ORG of I-ORG Defense O grant O number O W81XWH2110037 B-AWARD and O the O Rocky B-ORG Mountain I-ORG Center I-ORG for I-ORG Occupational I-ORG and I-ORG Environmental I-ORG Health I-ORG through O NIOSH O ERC O grant O number O T420H008414 B-AWARD This O work O was O supported O by O Research O Fund O for O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20160604 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2016M59034 O and O Postdoctoral B-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG 1501124C O Data O collection O and O Data O analysis O of O this O work O were O supported O by O The B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81702135 B-AWARD Zhejiang B-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG Research I-ORG Program I-ORG grant O number O 2016ZA124 B-AWARD 2017ZB057 O Zhejiang B-ORG Medicine I-ORG and I-ORG Hygiene I-ORG Research I-ORG Program I-ORG grant O number O 2016KYB101 B-AWARD 2015KYA100 O and O Zhejiang B-ORG Medical I-ORG Association I-ORG Clinical I-ORG Scientific I-ORG Research I-ORG Program I-ORG 2013ZYC-A19 O 2015ZYC-A12 O fund O the O work O The O research O leading O to O these O results O has O received O funding O from O the O European O Community’s O Seventh B-ORG Framework I-ORG Programme I-ORG FP7/2007-2013 O under O grant O agreement O no O 282996 B-AWARD W.L O Zijlema O is O supported O by O a O Sara O Borrell O grant O from O the O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III I-ORG CD17/00195 O Payam O Dadvand O is O funded O by O a O Ramón O y O Cajal O fellowship O RYC-2012-10995 O awarded O by O the O Spanish B-ORG Ministry I-ORG of I-ORG Economy I-ORG and I-ORG Competitiveness I-ORG This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 32001686 B-AWARD the O Project B-ORG of I-ORG Northeast I-ORG Agricultural I-ORG University I-ORG “Young I-ORG Talents” I-ORG 19QC28 O the O Heilongjiang B-ORG Postdoctoral I-ORG Financial I-ORG Assistance I-ORG LBH-Z21042 O and O the O University B-ORG Nursing I-ORG Program I-ORG for I-ORG Young I-ORG Scholars I-ORG with I-ORG Creative I-ORG Talents I-ORG in I-ORG Heilongjiang I-ORG Province I-ORG UNPYSCT-2020106 O This O project O was O supported O by O grants O from O the O University B-ORG of I-ORG Malaya I-ORG PG060-2016A O the O National B-ORG Geographic I-ORG Society I-ORG Asia59-16 O and O the O Malaysian B-ORG Nature I-ORG Society I-ORG Young O Environmental I-AWARD Research I-AWARD Grant I-AWARD 2016-12 O awarded O to O Voon-Ching O Lim O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the B-ORG Social I-ORG Development I-ORG Projects I-ORG of I-ORG Key I-ORG R&D I-ORG Programs I-ORG in I-ORG Jiangsu I-ORG Province I-ORG BE2019643 O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20171178 O and O General B-ORG Program I-ORG of I-ORG Jiangsu I-ORG Commission I-ORG of I-ORG Health I-ORG H2107083 O Matthew O B. O Sullivan O and O Simon O Roux O were O supported O by O grants O from O the O Gordon B-ORG and I-ORG Betty I-ORG Moore I-ORG Foundation I-ORG GBMF O 3790 O and O NSF B-ORG Biological I-ORG Oceanography I-ORG OCE-1536989 O awarded O to O Matthew O B. O Sullivan O Joanne O B. O Emerson O was O supported O by O the O US B-ORG Department I-ORG of I-ORG Energy I-ORG Office I-ORG of I-ORG Science I-ORG Office I-ORG of I-ORG Biological I-ORG and I-ORG Environmental I-ORG Research O under O the O Genomic O Science O program O Awards O DE-SC0010580 B-AWARD and O DE-SC0016440 B-AWARD The O work O conducted O by O the O US B-ORG Department I-ORG of I-ORG Energy I-ORG Joint I-ORG Genome I-ORG Institute O a O DOE O Office O of O Science O User O Facility O is O supported O under O Contract O No. O DE-AC02-05CH11231 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81601768 O 81630061 B-AWARD CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG 2017-I2M-1-014 O and O the O National B-ORG Basic I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG institutes I-ORG of I-ORG China I-ORG 2016ZX310048 O The O funders O had O no O role O in O the O study O design O data O collation O and O analysis O interpretation O of O data O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O no.2017YFA0204600 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O no. O 51802352 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG Central I-ORG South I-ORG University I-ORG Grant O no.2018zzts355 O This O work O was O funded O by O the O Medical B-ORG Research I-ORG Council I-ORG UK. O The O Dementia O Research O Centre O is O an O Alzheimer’s B-ORG Research I-ORG UK I-ORG coordinating O centre O and O is O supported O by O Alzheimer’s O Research O UK, O the O Brain O Research O Trust O and O the O Wolfson O Foundation O Queen O Square O Brain O Bank O is O supported O by O the O Reta O Lila O Weston O Institute O for O Neurological O Studies O the O Progressive O Supranuclear O Palsy O Europe O Association O and O the O Medical O Research O Council O UK. O IOCW O is O funded O by O a O Medical O Research O Council O Clinical O Research O Training O Fellowship O MR/M018288/1 O JDW O has O received O funding O support O from O the O Alzheimer’s O Society O JLH O is O supported O by O the O Multiple O System O Atrophy O Trust O the O Multiple O System O Atrophy O Coalition O Fund O Sophia O managed O by O the O King O Baudouin O Foundation O Alzheimer’s O Research O UK O and O CBD O Solutions O JDR O is O a O Medical O Research O Council O Clinician O Scientist O MR/M008525/1 O and O has O received O funding O from O the O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG Rare O Diseases O Translational O Research O Collaboration O BRC149/NS/MH O the O Bluefield O Project O and O the O Association O for O Frontotemporal O Degeneration O TL O is O funded O by O an O Alzheimer’s O Research O UK O Senior O Fellowship O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82072862 O 82272949 O the B-ORG Starting I-ORG Grant I-ORG from I-ORG The I-ORG Seventh I-ORG Affiliated I-ORG Hospital I-ORG Sun I-ORG Yat-sen I-ORG University I-ORG ZSQYRSF0008 O and O the B-ORG Guangdong I-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Digestive I-ORG Cancer I-ORG Research I-ORG No. O 2021B1212040006 O This O project O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31672543 B-AWARD Zhejiang B-ORG Province I-ORG “Sannongliufang” I-ORG Science I-ORG and I-ORG Technology I-ORG Cooperation I-ORG Project I-ORG Grant O No. O 2020SNLF007 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Zhejiang I-ORG Grant O No. O 2012C12009-2 B-AWARD and O the O National O Natural O Science O Foundation O of O China O Grant O No. O 31472184 B-AWARD This O work O was O supported O by O grants O from O the O Technical B-ORG Innovation I-ORG Special I-ORG Project I-ORG of I-ORG Hubei I-ORG Province I-ORG 2022BBA0054 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32202980 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG 2021CFB486 O and O the O Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG YFI O 202207 O This O work O was O supported O by O National B-ORG Cancer I-ORG Institute I-ORG 5U01 O CA163056-05 I-AWARD to O YS O Cancer B-ORG Center I-ORG Support I-ORG Grant I-ORG 2P30 O CA068485-19 I-AWARD to O YS O and O the O Robert B-ORG J. I-ORG Kleberg I-ORG Jr. I-ORG and I-ORG Helen I-ORG C. I-ORG Kleberg I-ORG Foundation I-ORG CQS O Pilot I-AWARD Project I-AWARD FY2016 I-AWARD to O QL O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81870373 B-AWARD 81500449 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG grant O number O 16ZR1428700 B-AWARD the O Shanghai B-ORG Hospital I-ORG Development I-ORG Center I-ORG New I-ORG Frontier I-ORG Technology I-ORG Joint I-ORG Research I-ORG Project I-ORG grant O number O SHDC12017115 B-AWARD and O Shanghai B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Key I-ORG Project I-ORG 2017ZZ02019 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O received O financial O support O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No: O 31271925 B-AWARD the B-ORG Special I-ORG Project I-ORG on I-ORG the I-ORG Integration I-ORG of I-ORG Industry I-ORG Education I-ORG and I-ORG Research I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG No: O 2013B090600015 B-AWARD and O the B-ORG Major I-ORG Project I-ORG on I-ORG synergy I-ORG innovation I-ORG in I-ORG enterprise-university-institute I-ORG of I-ORG Guangzhou I-ORG China I-ORG No: O 201604046011 B-AWARD The O authors O acknowledge O the O financial O support O of O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC2001100 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61774167 O 61801477 B-AWARD Instrument O Development O Program O of O the O Chinese O Academy O of O Sciences O YJKYYQ20170045 O Beijing B-ORG Municipal I-ORG Natural I-ORG Science I-ORG Foundation I-ORG 4192062 O and O Youth O Innovation O Promotion O Association O of O Chinese O Academy O of O Sciences O This O work O was O supported O by O UNAM-PAPIIT B-ORG IN201118 O and O IN203021 B-AWARD to O CQ) O and O by O Consejo B-ORG Nacional I-ORG de I-ORG Ciencia I-ORG y I-ORG Tecnología I-ORG in I-ORG Mexico I-ORG CONACyT O Fronteras O de O la O Ciencia O FC-2016/1503 B-AWARD to O CQ O and O fellowship O 463767 B-AWARD to O JSM O We O also O thank O PAPIIT O DGAPA O for O grant O IV200519 B-AWARD for O the O acquisition O of O the O QuantStudio O 5 O qPCR O system O Applied O Biosystems O Waltham O MA, O USA O and O CONACyT O for O grant O 253247 B-AWARD which O enabled O the O acquisition O of O the O Nikon O Eclipse O Ti O confocal O microscope O Nikon O Instruments O Tokyo O Japan O both O used O in O this O work O This O work O was O in O part O supported O by O a O grant O from O the O Japan B-ORG Agency I-ORG for I-ORG Medical I-ORG Research I-ORG and I-ORG Development/Japan O International O Cooperation O Agency O AMED O to O Y. O Hoshino O jp18fk0108043 O jp18fk0108064 B-AWARD jp18fk0108075 B-AWARD and O jp18jm0510004 B-AWARD by O Grants-in-Aid O for O Scientific O Research O C) O from O the O Japan B-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG JSPS O to O Y. O Hoshino O jp18K08312 O and O by O Grants-in-Aid B-ORG for I-ORG Early-Career I-ORG Scientists I-ORG to O H. O Fukano O jp18K15966 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O funded O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No.2021YFB3602200 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 61827806 B-AWARD 61974037 B-AWARD 62271184 B-AWARD Zhejiang B-ORG Province I-ORG Key I-ORG R&D I-ORG programs I-ORG Nos O 2021C05004 B-AWARD 2023C01192 B-AWARD NSFC-Zhejiang B-ORG and I-ORG the I-ORG Joint I-ORG Fund I-ORG for I-ORG the I-ORG Integration I-ORG of I-ORG Industrialization I-ORG and I-ORG information I-ORG No. O U20A20172 B-AWARD Zhejiang O Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O LZ22F010007 B-AWARD The O authors O gratefully O acknowledge O the O support O of O the O Micro-nano O Fabrication O Center O of O International O campus O Zhejiang O University O This O article O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81572608 B-AWARD 81172422 B-AWARD and O 81502209 B-AWARD the O Wuhan B-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG Grant O No. O 2017060201010170 B-AWARD and O the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2015AA020301 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 31300275 B-AWARD and O 31370289 B-AWARD the O Guangdong B-ORG Innovation I-ORG Research I-ORG Team I-ORG Fund I-ORG No. O 2014ZT05S078 B-AWARD and O the O Research B-ORG and I-ORG Development I-ORG Foundation I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Shenzhen I-ORG No. O JCYJ20140724165855348 B-AWARD This O research O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Number O 32060693 B-AWARD the O Major B-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Projects I-ORG in I-ORG Yunnan I-ORG Province I-ORG Grant O Number O 202102AE090052 B-AWARD and O 202102AE090001 B-AWARD and O the O Innovation B-ORG Team I-ORG Project I-ORG of I-ORG Yunnan I-ORG Province I-ORG Grant O Number O 202305AS350002 B-AWARD The B-ORG Science I-ORG and I-ORG Technology I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jilin I-ORG Provincial O Grant/Award O Number O 20200201125JC B-AWARD The B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O Grant/Award O Number O 81370240 B-AWARD The B-ORG Health I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG Jilin I-ORG Province O Grant/Award O Number O 2017J059 B-AWARD This O research O of O PZ O was O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82173630 O and O 81402765 B-AWARD the O Youth B-ORG Foundation I-ORG of O Humanity O and O Social O Science O Funded O by O Ministry O of O Education O of O China O 18YJC910002 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG of O China O BK20181472 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M630607 O and O 2019T120465 B-AWARD the O Qinglan O Research O Project O of O Jiangsu O Province O for O Young O and O Middle-Aged O Academic O Leaders O the O Six-Talent O Peaks O Project O in O Jiangsu O Province O of O China O WSN-087 O the O Training O Project O for O Youth O Teams O of O Science O and O Technology O Innovation O at O Xuzhou O Medical O University O TD202008 O the O Postdoctoral O Science O Foundation O of O Xuzhou O Medical O University O and O the O Statistical O Science O Research O Project O from O National O Bureau O of O Statistics O of O China O 2014LY112 O This O research O of O HX O was O also O supported O by O the O Industry-University O Collaborative O Education O Project O of O the O Higher O Education O Department O of O MOE O 202101085008 O the O Special O Subject O Key O Project O Jiangsu O Higher O Education O of O Jiangsu O Higher O Education O Association O 2022JSGJKT008 O and O Xuzhou O Social O Development O Key O R&D O Plan O KC21306 O This O research O of O SZ O was O supported O by O Postgraduate O Research O and O Practice O Innovation O Program O of O Jiangsu O Province O KYCX22_2960 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 31601846 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG China I-ORG Grant O No. O 2017JQ3014 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2016M602760 B-AWARD and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG China I-ORG Grant O no. O GK201603109 B-AWARD and O GK201603112 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC0910201 O the O Key B-ORG R&D I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2019B020226001 O and O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangzhou I-ORG 201704020176 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O partially O supported O by O Health B-ORG Labor I-ORG Sciences I-ORG Research I-ORG Grant I-ORG grant O no. O 20GC1022 B-AWARD to O M.T O Grant-in-Aid O for O Scientific O Research O 1) O The B-ORG Japan I-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG KAKENHI O JP22H00494 B-AWARD to O T.A.K O and O 2) O The O Japan B-ORG Agency I-ORG for I-ORG Medical I-ORG Research I-ORG and I-ORG Development I-ORG AMED O JP21wm0425010 B-AWARD to O T.A.K O The O authors O are O grateful O to O Universidade B-ORG Paranaense O Graduate O Program O in O Medicinal O Plants O and O Phytotherapeutics O in O Basic O Attention O and O Graduate O Program O in O Animal O Science O with O Emphasis O on O Bioactive O Products O for O financial O support O This O work O was O supported O by O grants O from O the O Conselho O Nacional O de O Desenvolvimento O Científico O e O Tecnológico O CNPq O no. O 800435/2018-4 B-AWARD Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG CAPES O no. O PNPD20132409-40028011002P4 B-AWARD and O Fundação B-ORG Araucária I-ORG FUNDAÇÃO O ARAUCÁRIA O no. O 47661.491.48325.12122016 B-AWARD This O research O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFD0500501 B-AWARD the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG No. O 2012BAD39B01 B-AWARD the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG No. O CARS-42 B-AWARD and O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG No. O ASTIP-IAS07 B-AWARD Financial O support O came O from O the O Key B-ORG Research I-ORG I-ORG Development I-ORG Plan I-ORG of I-ORG Shaanxi I-ORG Province I-ORG of I-ORG China I-ORG General O Project O grant O no. O K3310217014 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG grant O no. O K308021505 B-AWARD and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O nos O 81770514 B-AWARD and I-AWARD 81270439 O This O study O was O supported O in O part O by O grants O from O the B-ORG National I-ORG Clinical I-ORG Key I-ORG Specialty I-ORG Construction I-ORG Program I-ORG No. O 2013 B-AWARD Fujian B-ORG Provincial I-ORG Health I-ORG Systemic I-ORG Youth I-ORG Backbone I-ORG Training I-ORG Projects I-ORG No. O 2015-ZQN-ZD-9 B-AWARD the B-ORG Leading I-ORG Project I-ORG Foundation I-ORG of I-ORG Science I-ORG Department I-ORG of I-ORG Fujian I-ORG Province I-ORG No. O 2015Y0011 B-AWARD and O the O Leading O Project O Foundation O of O Science O Department O of O Fujian O Province O No. O 2016Y0019 B-AWARD We O received O funding O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG under O grant O 61871061 B-AWARD to O Hongchun O Qu, O the O Sub-project O of O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG under O grant O 2016YFC500304-01 B-AWARD to O DW, O and O the O National B-ORG key I-ORG R&D I-ORG plan I-ORG “Research O development O and O demonstration O of O key O technologies O for O berry O complex O ecological O cultivation” O 2022YFF1300503-03 B-AWARD to O Dianwen O Wei O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81630028 O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG of I-ORG China I-ORG BE2016610 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC1300504 O and O Jiangsu B-ORG Province I-ORG Key I-ORG Medical I-ORG Discipline I-ORG ZDXKA2016020 O This O work O was O supported O by O the O Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG 20YYJC3358 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82001728 O 81973540 B-AWARD 82271828 B-AWARD 1·3·5 B-ORG project I-ORG for I-ORG Outstanding I-ORG interdisciplinary I-ORG project I-ORG of I-ORG West I-ORG China I-ORG Hospital I-ORG Sichuan I-ORG University I-ORG ZYGD18015 O ZYJC18003 B-AWARD ZYJC18024 O from B-ORG zero I-ORG to I-ORG one I-ORG Innovative I-ORG Research I-ORG Program I-ORG of I-ORG Sichuan I-ORG University I-ORG 2022SCUH0020 O This O research O was O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51979259 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2019YFE0105100 B-AWARD and O Research B-ORG Council I-ORG of I-ORG Norway I-ORG AutoPRO O No. O 309628 B-AWARD This O work O was O supported O by O the O National O Institute O of O Environmental O Health O Sciences O of O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG R01 O ES022698 I-AWARD and O U01 B-AWARD ES027237 O the O National O Science O Foundation O and O the O Environmental B-ORG Protection I-ORG Agency I-ORG DBI-1266377 O One O Hundred O Talents O Bairen O A) O program O of O Chinese B-ORG Academy I-ORG of I-ORG Sciences O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2014CB932000 O the O Strategic O Priority O Research O Program O of O the O Chinese O Academy O of O Sciences O XDB14000000 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21425731 O 21377159 B-AWARD and O 21637004 B-AWARD and O 31570899 B-AWARD This O research O was O supported O by O the O Liaoning B-ORG Revitalization I-ORG Talents I-ORG Program I-ORG XLYC2002065 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31970183 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2022YFE0108200 O the O Graduate B-ORG Innovation I-ORG Cultivation I-ORG Fund I-ORG of I-ORG Shenyang I-ORG Agricultural I-ORG University I-ORG Nos O 2021YCXB09 B-AWARD and O 2022YCXS19 B-AWARD and O open B-ORG funds I-ORG from I-ORG the I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Plant I-ORG Physiology I-ORG and I-ORG Biochemistry I-ORG SKLPPBKF1905 O This O Study O was O funded O by O Chinese B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG No.81571234 O Key B-ORG research I-ORG and I-ORG development I-ORG plan I-ORG of I-ORG Shandong I-ORG Province I-ORG 2018GSF118235 O Shandong B-ORG Province I-ORG medical I-ORG science I-ORG and I-ORG technology I-ORG development I-ORG projects I-ORG 2014WS0260 O and O Yantai B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Project I-ORG 2014WS035 O 2016WS037 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O numbers O 31372558 O I-AWARD 31672689 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG Grant O number O 2017A030311032 O and O Department B-ORG of I-ORG Education I-ORG of I-ORG Guangdong I-ORG Province I-ORG Grant O number O 2017KZDXM033 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 61771184,http://www.nsfc.gov.cn B-AWARD Key B-ORG Research I-ORG Project I-ORG of I-ORG Education I-ORG Bureau I-ORG of I-ORG Henan I-ORG Province I-ORG China I-ORG Grant O No. O 17A416002,http://www.haedu.gov.cn/2016/07/05/1467700050775.html B-AWARD and O Key B-ORG Scientific I-ORG and I-ORG Technological I-ORG Project I-ORG of I-ORG Henan I-ORG Province I-ORG China I-ORG Grant O No. O 172102210040,http://www.hnkjt.gov.cn/2016/09/09/1473417379451.html B-AWARD All O of O the O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Our O work O is O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG under O grant O 2017YFB1002502 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61671067 O the O Key B-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61731003 O the O Interdiscipline B-ORG Research I-ORG Funds I-ORG of I-ORG Beijing I-ORG Normal I-ORG University I-ORG and I-ORG the I-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2017XTCX04 O This O work O was O supported O by O the O Irish O Research O Council O for O Science O Engineering O and O Technology O post-graduate O fellowship O the O Health B-ORG Research I-ORG Board I-ORG CSA/2007/11 O Science B-ORG Foundation I-ORG Ireland I-ORG 08/SRC/B1410 O the O Cancer O Clinical O Research O Trust O the O Irish B-ORG Cancer I-ORG Society I-ORG Collaborative O Cancer O Research O Centre O BREAST-PREDICT O Grant O CCRC13GAL O and O Erasmus O SFI O and O EACR O travel O fellowships O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81470187 B-AWARD Grant O NO.81270882 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Tianjin I-ORG Grant O Nos O 15ZXHLSY00460 B-AWARD and O 18JCYBJC26100 B-AWARD and O the O Shanxi B-ORG Provincial I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG research O project O Grant O No. O 2017043 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O J.W O was O supported O by O the O China B-ORG Scholarship I-ORG Council I-ORG CSC O No: O 201609110097 B-AWARD M.Y O was O founded O by O Liaoning B-ORG Pan I-ORG Deng I-ORG Xue I-ORG Zhe I-ORG Scholar I-ORG No. O XLYC2002061 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 82173768 B-AWARD and O the O Overseas B-ORG Expertise I-ORG Introduction I-ORG Project I-ORG for I-ORG Discipline I-ORG Innovation I-ORG “111 O Project” O No. O D20029 B-AWARD This O work O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG 2018YFC1314905 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81170759 O 81770813 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG 15411960600 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31600085 O the O Foreword B-ORG Key I-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG QYZDB-SSW-DQC013 O the O National B-ORG Key I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC1402300 O the O State O Key O Laboratory O of O Microbial O Metabolism O Shanghai O JiaoTong O University O MMLKF15-04 O and O the O Yantai O Science O and O Technology O Project O 2017YT06000325 O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31870728 O and I-AWARD 31470738 O the B-ORG National I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2014CB910103 O and O the B-ORG Science I-ORG Foundation I-ORG of I-ORG Wuhan I-ORG University I-ORG 2042016kf0169 O This O work O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 52162004 O Guangxi B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2017GXNSFDA198052 O 2021GXNSFAA075043 B-AWARD and O 2022GXNSFBA035499 B-AWARD Nanning B-ORG Excellent I-ORG Youth I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Talent I-ORG Cultivation I-ORG Project I-ORG RC20220106 O and O Guangxi B-ORG Higher I-ORG Education I-ORG Institutes I-ORG Young I-ORG Teachers I-ORG Basic I-ORG Ability I-ORG Improvement I-ORG Project I-ORG 2019KY0170 O This O work O was O supported O by O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG 2012BAD19B06 O the O National B-ORG Sparking I-ORG Plan I-ORG Project I-ORG 2012GA811001 O and O Technological B-ORG Projects I-ORG of I-ORG Chongqing I-ORG cstc2014yykfB80007 O cstc2014fazktjcsf80033 O This O work O was O financially O supported O by O the B-ORG Brainstorm I-ORG Project I-ORG on I-ORG Social I-ORG Development I-ORG of I-ORG Shaanxi I-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG No. O 2016SF-412 B-AWARD the B-ORG Special I-ORG Fund I-ORG for I-ORG Basic I-ORG Scientific I-ORG Research I-ORG of I-ORG Central I-ORG Colleges I-ORG of I-ORG Chang'an I-ORG University I-ORG No. O 310821172004 I-AWARD No. I-AWARD 310821153312 I-AWARD No. I-AWARD 310821165011 O and O the O joint O grant O No. O 2017CDJSK03XK19 I-AWARD No. I-AWARD 106112016CDJSK03JD01 O supported O by O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG Chongqing I-ORG University I-ORG This O work O was O supported O by O grant O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81570363 O the O Priority O Academic O Program O Development O of O Jiangsu O Higher O Education O Institutions O PAPD O Shanghai B-ORG Pudong I-ORG New I-ORG Area I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Fund I-ORG PKJ2014-Y09 O and O Shanghai B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Research I-ORG Project I-ORG 201440309 O This O work O was O supported O by O the O Liaoning B-ORG Province I-ORG Key I-ORG Laboratory I-ORG Project I-ORG of I-ORG Breast I-ORG Cancer I-ORG Research I-ORG Grant O Number O 2016-26-1 B-AWARD Key B-ORG Research I-ORG Project I-ORG of I-ORG Liaoning I-ORG Grant O Number O 2018225076 B-AWARD Special B-ORG Fund I-ORG for I-ORG Clinical I-ORG Research I-ORG of I-ORG Wu I-ORG Jieping I-ORG Medical I-ORG Foundation I-ORG Grant O Number O 320.6750.18541 B-AWARD and O CSCO-Hengrui B-ORG Cancer I-ORG Research I-ORG Foundation I-ORG Grant O Number O Y-HR2018-362 B-AWARD This O study O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 71603199 B-AWARD to O KY O the O Central B-ORG University I-ORG Basic I-ORG Research I-ORG Fund I-ORG 2015qngz05 O to O YF O and O the O “Young O Talent I-AWARD Support I-AWARD Plan” O of O Xi’an B-ORG Jiaotong I-ORG University I-ORG to O YF. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O funding O from O the O Peanut B-ORG Institute I-ORG 2019 O PID2020-114022RB-I00 B-AWARD and O CIBEROBN B-AWARD from O the O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III O ISCIII B-AWARD from O the O Ministerio B-ORG de I-ORG Ciencia O Innovación B-ORG y I-ORG Universidades I-ORG AEI/FEDER I-ORG UE I-ORG Generalitat I-ORG de I-ORG Catalunya I-ORG GC) O 2021-SGR-00334 O and O INSA-UB O is O Maria O de O Maeztu O Unit O of O Excellence O grant O CEX2021-001234-M B-AWARD funded O by O MICIN/AEI/FEDER B-ORG UE O The O current O study O was O supported O by O the O National O Key O R&D O Program O of O China O No. O 2017YFB0308000 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51775197 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O China O No. O 2014A030312017 B-AWARD and O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2017M622679 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61925307 O and O 62003338 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 238308 O the O Nature B-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province I-ORG of I-ORG China I-ORG 2021-BS-021 O and O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Robotics I-ORG 2020-Z16 O This O research O was O funded O by O the O National B-ORG Science I-ORG Foundation I-ORG grant O IOS-1456844 B-AWARD J.F.H O the O Arnold B-ORG and I-ORG Mabel I-ORG Beckman I-ORG Foundation I-ORG Beckman B-AWARD Scholars I-AWARD Program I-AWARD J.C.P O and O the O Vanderbilt B-ORG University I-ORG Vanderbilt B-AWARD Undergraduate I-AWARD Summer I-AWARD Research I-AWARD Program I-AWARD R.T O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81572940 O 81622007 I-AWARD and I-AWARD 91439131 O the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20140004 O the O National O High O Technology B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 863 I-ORG Program I-ORG of I-ORG China I-ORG SQ2015AA020948 O This O work O was O supported O by O The B-ORG Project I-ORG of I-ORG Philosophy I-ORG and I-ORG Social I-ORG Science I-ORG Research I-ORG in I-ORG Colleges I-ORG and I-ORG Universities I-ORG in I-ORG Jiangsu I-ORG Province I-ORG Project O No. I-AWARD 2017SJB0218 O The B-ORG 13th I-ORG Five-Year I-ORG Plan I-ORG of I-ORG Educational I-ORG Science I-ORG in I-ORG Jiangsu I-ORG Province I-ORG Project O No. I-AWARD C-c/2016/01/13 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG of I-ORG China I-ORG Project O No. I-AWARD BK20171036 O This O research O was O supported O by O Basic O Science O Research O Program O through O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O funded O by O the O Ministry O of O Education O NRF-2017R1D1A1B03032768 O Clinical O Research O Institute O grant O CMCDJ-P-2018–015 O funded O by O The B-ORG Catholic I-ORG University I-ORG of I-ORG Korea I-ORG Daejeon I-ORG St. I-ORG Mary’s I-ORG Hospital O and O the B-ORG Otorhinolaryngology I-ORG Alumni I-ORG Fund I-ORG of I-ORG the I-ORG Catholic I-ORG University I-ORG of I-ORG Korea I-ORG made O in O the O program O year O of O 2019 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG of I-ORG China I-ORG great O number O 2022JJ40207 B-AWARD Changsha B-ORG Municipal I-ORG Natural I-ORG Science I-ORG Foundation I-ORG great O number O kq2202470 B-AWARD Hunan B-ORG Provincial I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG great O number O 2018SK2062 B-AWARD The O APC O was O funded O by O Hunan O Provincial O Key O Research O and O Development O Program O great O number O 2018SK2062 O This O study O was O funded O by O the O Health O and O Labor O Sciences O Research O Grant O for O Research O on O Rare O and O Intractable O diseases O and O Comprehensive O Research O on O Disability O Health O and O Welfare O from O the O Ministry B-ORG of I-ORG Health I-ORG Labour I-ORG and I-ORG Welfare I-ORG of O Japan O S.U O H29-Nanchitou(Nan)-Ippan-031 B-AWARD the O Grant-in-Aid O from O Japan B-ORG Agency I-ORG for I-ORG Medical I-ORG Research I-ORG and I-ORG Development I-ORG AMED O S.U O 16kk0205010h0001 B-AWARD 18ek0109363h0001 O and O the O Grant-in-Aid O for O Scientific O Research O A) O from O the O Ministry B-ORG of I-ORG Education I-ORG Culture I-ORG Sports I-ORG Science I-ORG and I-ORG Technology I-ORG of O Japan O S.U O 15H02565 B-AWARD The O work O was O supported O by O grants O from O Agence B-ORG Nationale I-ORG de I-ORG la I-ORG Recherche I-ORG ANR-13-BSV2-0001 O Canceropôle B-ORG Ile I-ORG de I-ORG France I-ORG 2014-1-SEIN-01-ICR-1 O and O Ligue B-ORG Contre I-ORG le I-ORG Cancer I-ORG Ile I-ORG de I-ORG France I-ORG Comité O de O l'Essonne O M27216 B-AWARD Comité O de O Paris O RS19/75-67 O A.C O received O funding O from O Agence O Nationale O de O la O Recherche O ANR-13-BSV2-0001 O L.B O from O the O “Ministère O de O la O Recherche O et O de O l’Enseignement O Supérieur” O and O from O the O “Fondation O pour O la O Recherche O Médicale” O SLM B-ORG grant O number O 2017229 B-AWARD and O CLL B-ORG grant O number O 1193826 B-AWARD are O supported O by O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG NHMRC O Investigator O Grants O and O KL O by O a O NHMRC O Senior O Research O Fellowship O grant O number O 1155005 B-AWARD This O project O has O received O funding O from O Enterprise B-ORG Ireland I-ORG EI) O and O from O the O European O Union’s O Horizon O 2020 O research O and O innovation O programme O under O the O Marie O Slodowska-Curie O grant O agreement O No B-AWARD 713654 O This O publication O has O been O supported O in O part O by O TACTIC—TAiloring O the O Communication O of O risk O To O Individual O breast O Cancer O patients O Irish B-ORG Research I-ORG Council I-ORG IRC O grant O CLNE/2018/1338 B-AWARD CAROLINE O Postdoctoral O Fellowship O This O publication O emanated O from O research O supported O in O part O by O research O grants O from O Science B-ORG Foundation I-ORG Ireland I-ORG SFI O under O Grant O Numbers O 15/IA/3104 B-AWARD and I-AWARD 18/SPP/3522 I-AWARD This O material O is O also O based O upon O works O supported O by O the O Irish B-ORG Cancer I-ORG Society I-ORG Collaborative O Cancer O Research O Centre O BREAST-PREDICT O Grant O CCRC13GAL B-AWARD This O work O was O financially O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81271826 O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG for I-ORG Infectious I-ORG Diseases I-ORG 2014ZX10001001-002-004 O and O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Infectious I-ORG Disease I-ORG Prevention I-ORG and I-ORG Control I-ORG 2015SKLID506 O This O work O was O supported O by O grants O awarded O to O MCVP O by O the O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq O 310634/2013-0 B-AWARD the O Fundação B-ORG Carlos I-ORG Chagas I-ORG Filho I-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG do I-ORG Rio I-ORG de I-ORG Janeiro I-ORG FAPERJ O 203.045/2016 B-AWARD and O the O Newton B-ORG Fund/CONFAP/MRC I-ORG UK-Brazil I-ORG Negleted I-ORG Disease I-ORG Call I-ORG MR/N017420/1 O COS O was O the O recipient O of O a O fellowship O from O CNPq O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Danish B-ORG National I-ORG Research I-ORG Foundation I-ORG DNRF94 O the O Initiative O d’Excellence O Chaires O d’attractivité O Université O de O Toulouse O OURASI O and O the O Villum B-ORG Fonden I-ORG miGENEPI B-AWARD This O project O has O received O funding O from O the O European B-ORG Research I-ORG Council I-ORG ERC O under O the O European O Union’s O Horizon O 2020 O research O and O innovation O programme O grant O agreement O No. O 681605 B-AWARD This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U1603234 O the O Program B-ORG for I-ORG Innovative I-ORG Research I-ORG Team I-ORG of I-ORG Grape I-ORG Germplasm I-ORG Resources I-ORG and I-ORG Breeding I-ORG 2013KCT-25 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2452019170 O This O work O was O funded O by O NIH-NIMHD B-ORG U54MD007598 B-AWARD NIH/NCI1U54CA14393 B-AWARD U56 B-AWARD CA101599-01 O Department-of-Defense B-ORG Breast I-ORG Cancer I-ORG Research I-ORG Program I-ORG grant O BC043180 B-AWARD NIH/NCATS O CTSI O UL1TR000124 O to O J.V O Vadgama O and O Accelerating B-ORG Excellence I-ORG in I-ORG Translational I-ORG Science I-ORG Pilot I-ORG Grants O G0812D05 B-AWARD NIH/NCI B-AWARD SC1CA200517 O and O 9 O SC1 O GM135050-05 B-AWARD to O Y. O Wu. O This O research O was O funded O by O the O National B-ORG Key I-ORG Plan I-ORG for I-ORG Research I-ORG and I-ORG Development I-ORG of I-ORG China I-ORG 2019YFC1905600 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41571520 O Sichuan B-ORG Youth I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Team I-ORG Funding I-ORG 2022JDTD0005 O and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2682021ZTPY088 O We O thank O the B-ORG independent I-ORG subject I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Plateau I-ORG Ecology I-ORG and I-ORG Agriculture I-ORG grant O no. O 2018-ZZ-1 B-AWARD the B-ORG Project I-ORG of I-ORG Qinghai I-ORG Science I-ORG I-ORG Technology I-ORG Department I-ORG grant O nos O 2018-ZJ-Y01 B-AWARD 2019-ZJ-935Q O the B-ORG International I-ORG Cooperation I-ORG Project I-ORG of I-ORG Qinghai I-ORG Province I-ORG National I-ORG Science I-ORG Foundation I-ORG grant O no. O 2017-HZ-810 B-AWARD and O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O no. O 21868030 B-AWARD for O financial O support O This O study O was O supported O by O Neuroblastoma O Australia O Christina O Signorelli O is O supported O by O Neuroblastoma O Australia O and O a O Cancer B-ORG Institute I-ORG NSW I-ORG Early O Career O Fellowship O 2020/ECF1144 O Claire O E. O Wakefield O is O supported O by O the O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG of O Australia O APP2008300 O Natasha O Nassar O is O funded O by O the O Financial B-ORG Markets I-ORG Foundation I-ORG for I-ORG Children I-ORG and O the O National O Health O and O Medical O Research O Council O of O Australia O APP1197940 O This O work O was O supported O by O the O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 32270789 B-AWARD 62062043 B-AWARD 32260154 B-AWARD 62162032 B-AWARD the O Department B-ORG of I-ORG Education I-ORG of I-ORG Jiangxi I-ORG Province I-ORG GJJ211349 O the O Science B-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG of I-ORG Jingdezhen I-ORG City I-ORG China I-ORG 20212GYZD009-01 O This O work O was O supported O by O the O Foundation O of O Precision B-ORG Medicine I-ORG Research I-ORG State I-ORG Key I-ORG Development I-ORG Program I-ORG China I-ORG 2017YFC0909600 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81670774 O Beijing B-ORG Hospitals I-ORG Authority I-ORG Youth I-ORG Programme I-ORG QML20170205 O and O Scientific B-ORG Research I-ORG Fund I-ORG of I-ORG Beijing I-ORG Tongren I-ORG Hospital I-ORG Capital I-ORG Medical I-ORG University I-ORG 2014-YJJ-GGL-040 O This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG grant O number O 2016YFD0300700/2016YFD0300706 B-AWARD Postgraduate B-ORG Research I-ORG Practice I-ORG Innovation I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG grant O number O KYCX19_0530 B-AWARD and O Chinese B-ORG Universities I-ORG Scientific I-ORG Fund I-ORG grant O number O KYZ201710 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 31830075 B-AWARD The O funding O bodies O played O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81571450 O 81470299 B-AWARD the O Basic B-ORG Work I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG China I-ORG 2014FY110700 O and O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Hunan I-ORG Province I-ORG 2017SK2153 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81700941 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Sichuan I-ORG Province I-ORG No.2020YFS0087 O and O Sichuan B-ORG University-Luzhou I-ORG City I-ORG cooperation I-ORG project I-ORG No.2018CDLZ-14 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Australian O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG Grant O APP1099912 O The O University B-ORG of I-ORG Sydney I-ORG Fellowship O G197581 O NSW O Ministry O of O Health O under O the O NSW B-ORG Health I-ORG Early-Mid O Career O Fellowships O Scheme O H18/31086 O to O SHO O This O work O was O financially O supported O by O grants O from O the B-ORG Six I-ORG talent I-ORG peaks I-ORG project I-ORG in I-ORG Jiangsu I-ORG Province I-ORG of I-ORG china I-ORG WSN-088(IB16 O the B-ORG key I-ORG young I-ORG talents I-ORG of I-ORG medicine I-ORG in I-ORG Jiangsu I-ORG Province I-ORG QNRC2016591 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81472809,81502653 O 81672983,81703028 B-AWARD the B-ORG Priority I-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O JX10231801 O NCI B-ORG Mouse I-ORG Models I-ORG Consortium I-ORG UO1CA141545 O This O research O was O funded O by O the O National B-ORG Institutes I-ORG of I-ORG Health O grant O number O R01DK123264 O the O American B-ORG Heart I-ORG Association O grant O number O 19TPA34850057 B-AWARD and O the O University B-ORG of I-ORG Arkansas I-ORG for I-ORG Medical I-ORG Sciences I-ORG Barton B-AWARD Pilot I-AWARD Award I-AWARD This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81471708 B-AWARD Shanghai B-ORG Jiao I-ORG Tong I-ORG University I-ORG Medical I-ORG Engineering I-ORG Cross I-ORG research I-ORG fund I-ORG No. O YG2016MS55 B-AWARD and O Shanghai B-ORG Municipal I-ORG Education I-ORG Commission— I-ORG Gaofeng I-ORG Clinical I-ORG Medicine I-ORG Grant I-ORG Support I-ORG No.20172010 O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 82270372 B-AWARD 82060656 B-AWARD 81870037 B-AWARD 82260087 B-AWARD 82160013 B-AWARD 82160007 B-AWARD Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Yunnan I-ORG Province I-ORG No. O 202105AF150015 B-AWARD 202102AA310030 B-AWARD 202001AY070001-196 B-AWARD Kunming B-ORG Development I-ORG and I-ORG Reform I-ORG Commission I-ORG 202202 O The O study O was O supported O by O the O National B-ORG key I-ORG research I-ORG and I-ORG development I-ORG program I-ORG China I-ORG 2019YFC1200503 O CAS B-ORG Projects I-ORG for I-ORG Young I-ORG Scientists I-ORG in I-ORG Basic I-ORG Research I-ORG YSBR-080 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32125032 O and O 31830073 B-AWARD and O the O Second B-ORG Tibetan I-ORG Plateau I-ORG Scientific I-ORG Expedition I-ORG and I-ORG Research I-ORG Program I-ORG STEP O 2021QZKK0100 O This O work O was O supported O by O the O Medical B-ORG Research I-ORG Council I-ORG grant O MR/L009226/1 B-AWARD the O Comprehensive O Biomedical O Research O Centre O at O Imperial O College O London O of O the O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG grant O P45272 B-AWARD Imperial O National O Health O Service O Trust O and O the O Genesis B-ORG Research I-ORG Trust I-ORG grant O P51389 B-AWARD This O research O was O financially O supported O by O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 21576134 B-AWARD 21606127 B-AWARD “863” B-ORG program I-ORG of I-ORG China I-ORG Grant O No. O 2015AA021005 B-AWARD and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2016YFA0204300 B-AWARD This O study O was O supported O by O grants O from O the O European B-ORG Union’s I-ORG Horizon I-ORG 2020 I-ORG research O and O innovation O programme O under O grant O agreement O No O 635316 B-AWARD ATHLOS O project O the O Swedish B-ORG Research I-ORG Council I-ORG Projects O No O 2013–5104 B-AWARD and O 2013–5474 B-AWARD and O the O China B-ORG Scholarship I-ORG Council I-ORG No O 201600160078 B-AWARD M.G O This O study O was O funded O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG grant O number O 2017YFD0200400 B-AWARD awarded O to O Assoc O Prof O Weiyi O He O the O Fujian B-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG grant O number O 2018NZ0002-1 B-AWARD awarded O to O Prof O Minsheng O You O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG grant O number O 2019J01369 B-AWARD awarded O to O Assoc O Prof O Weiyi O He O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O authors O received O financial O support O for O the O research O authorship O and/or O publication O of O this O article O from O the B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG Nos.2014A020212240,2014A020209051 O 2017A020215053 B-AWARD the B-ORG Medical I-ORG Research I-ORG Fund I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O A2015203 B-AWARD and O the B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Guangzhou I-ORG No. O 201804010379 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG 21ZR1407100 O and O 21S11905300 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Fund I-ORG of I-ORG China I-ORG 82273864 O and O 81573358 B-AWARD and O the O Development B-ORG Project I-ORG of I-ORG Shanghai I-ORG Peak I-ORG Disciplines-Integrative I-ORG Medicine I-ORG 20180101 O This O study O was O supported O by O American B-ORG Diabetes I-ORG Association I-ORG www.diabetes.org O Basic O Science O grant O 1-13-BS-038 O HD O JDRF B-ORG www.jdrf.org O Strategic O Research O Agreement O 2-SRA-2015-77-QR B-AWARD HD O National B-ORG Institute I-ORG of I-ORG Diabetes I-ORG and I-ORG Digestive I-ORG and I-ORG Kidney I-ORG Diseases I-ORG NIDDK,www.niddk.nih.gov O 1R01 O DK-102911 I-AWARD HD O and O National B-ORG Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases I-ORG NIAID,www.niaid.nih.gov O Research O Training O in O Immunology O grant O T32-AI-007309 B-AWARD JHE O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81870373 B-AWARD 81500449 B-AWARD Shanghai B-ORG Hospital I-ORG Development I-ORG Center I-ORG New I-ORG Frontier I-ORG Technology I-ORG Joint I-ORG Research I-ORG Project I-ORG grant O number O SHDC12017115 B-AWARD and O Shanghai B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning O China O 2017ZZ02019 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81373065 O 81773490 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG program I-ORG of I-ORG China I-ORG 2017YFC1200203 O and O the O Fourth B-ORG Round I-ORG of I-ORG Three-year I-ORG Action I-ORG Plan I-ORG and I-ORG Key I-ORG Discipline I-ORG Program I-ORG on I-ORG Public I-ORG Health I-ORG System I-ORG Construction I-ORG of I-ORG Shanghai I-ORG 15GWZK0202 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32072025 O 31801430 B-AWARD the B-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Crop I-ORG Gene I-ORG Exploration I-ORG and I-ORG Utilization I-ORG in I-ORG Southwest I-ORG China I-ORG SKL-ZY202232 O and O the B-ORG Science I-ORG I-ORG Technology I-ORG Development I-ORG Program I-ORG of I-ORG Jilin I-ORG Province I-ORG 20200402034NC O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O NO. O 81572514 B-AWARD 81772728 B-AWARD 81772719 B-AWARD 81472384 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Grant O No. O 2015A030311011 B-AWARD Guangdong B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Fund I-ORG 2017B020227007 O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG Grant O No. O 201604020158 B-AWARD 201604020177 B-AWARD This O work O has O been O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61873202 B-AWARD to O SWZ O No. O 11661141019 B-AWARD and O 61621003 B-AWARD to O SZ O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG CAS O No. O XDB13040600 B-AWARD the O National B-ORG Ten I-ORG Thousand I-ORG Talent I-ORG Program I-ORG for I-ORG Young I-ORG Top-notch I-ORG Talents I-ORG the I-ORG Key I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences O No. O KFZD-SW-219 B-AWARD and O CAS B-ORG Frontier I-ORG Science I-ORG Research I-ORG Key I-ORG Project I-ORG for I-ORG Top I-ORG Young I-ORG Scientist I-ORG No. O QYZDB-SSW-SYS008 B-AWARD The O funding O body O did O not O play O any O roles O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG of O China O 2021JQ-013 O 2022JQ-985 B-AWARD the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shaanxi I-ORG 2020ZDLSF02-04 O and O the O General B-ORG Financial I-ORG Grant I-ORG from I-ORG the I-ORG China I-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2019M663741 O This O research O project O was O financed O in O part O by O the O Austrian B-ORG Research I-ORG Promotion I-ORG Agency I-ORG grant I-ORG “APOSEC” O 852748 O and O 862068 B-AWARD 2015–2019 O in O part O by O Vienna B-ORG Business I-ORG Agency I-ORG “APOSEC O to O clinic,” O 2343727 O 2018–2020 O and O in O part O by O Aposcience O AG O under O group O leader O H.J.A O M.M O was O funded O by O Sparkling O Science O Program O of O the O Austrian B-ORG Federal I-ORG Ministry I-ORG of I-ORG Education I-ORG Science I-ORG and I-ORG Research I-ORG SPA06/055 O This O study O was O funded O byMarie O Curie I-ORG Research(Project O Grant O A15867 B-AWARD The O funder O was O not O involved O in O the O design O of O the O study O data O collection O analysis O interpretation O writing O of O the O manuscript O or O decision O to O submit O for O publication O Dr. O Anand O is O supported O by O a O clinical O lectureship O from O theChief O Scientist I-ORG Office(PCL/18/05 O Prof O Weir O was O supported O in O this O work O byNHS O Lothianvia O theEdinburgh O Clinical O Trials O Unit O Prof O Mills O is O supported O by O the O Butler O Senior O Research O Fellowship O FS/16/14/32023 O from O theBritish O Heart I-ORG Foundation I-ORG This O study O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81671025 B-AWARD Beijing O China O and O Foundation B-ORG of I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Shandong I-ORG Province I-ORG 2015GSF118186 B-AWARD Ji’nan O China O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2018ZB0105 B-AWARD Ji’nan O China O This O research O was O funded O by O grants O provided O to O Maria O G. O Tavares O do O Carmo O by O Fundação B-ORG de I-ORG Amparo I-ORG a I-ORG Pesquisa I-ORG do I-ORG Rio I-ORG de I-ORG Janeiro I-ORG FAPERJ I-ORG E-26/111.725/2013 B-AWARD and O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq O 305329/2016-2 B-AWARD Coordenação O de O Aperfeicoamento O de O Pessoal O de O Nível O Superior O CAPES O funded O a O postgraduate O scholarship O to O Rafael O C. O Sales O Finance O Code O 001 O By O the O Spanish O “Agencia O Estatal O de O Investigación” O and O European O FEDER O Funds O to O Alberto O Dávalos O AGL2016-78922-R O and O by O the O Fundación B-ORG Ramón I-ORG Areces I-ORG CIVP18A3888 O to O Alberto O Dávalos O Judit O Gil-Zamorano O and O Roberto O Martín-Hernández O This O work O was O supported O by O The B-ORG National I-ORG S&T I-ORG Major I-ORG Project I-ORG 2012ZX10005009-003 O and O 2014ZX10004005-001 B-AWARD National B-ORG 973 I-ORG Project I-ORG 2011CB505404 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81302516 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Basic B-ORG Research I-ORG and I-ORG Frontier I-ORG Technology I-ORG Projects I-ORG of I-ORG Beibei I-ORG District I-ORG Chongqing I-ORG China I-ORG 2019-5 O Technology B-ORG Innovation I-ORG and I-ORG Application I-ORG Demonstration I-ORG Research I-ORG Project I-ORG of I-ORG Chongqing I-ORG China I-ORG cstc2018jscx-msybX0084 O and O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC0101301 O This O research O was O financially O supported O by O the O grants O from O Liaoning B-ORG Revitalization I-ORG Talents I-ORG Program I-ORG XLYC2007013 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 41706117 B-AWARD and O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC1402305 O 2022YFC3105600 B-AWARD The O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 51808228 B-AWARD and O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M643089 O funded O this O research O The O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2018MS92 O funded O the O APC O This O work O was O supported O by O the O National B-ORG High-tech I-ORG R&D I-ORG Program I-ORG 863 I-ORG Program I-ORG No. O 2015AA020306 B-AWARD the O Sichuan B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG Grant O Numbers O 2016JY0022 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Numbers O 81271127 B-AWARD 81322013 B-AWARD and O the O Program B-ORG of I-ORG International I-ORG Science I-ORG and I-ORG Technology I-ORG Cooperation I-ORG Grant O Number O 2014DFA31990 B-AWARD We O acknowledge O the O financial O support O from O NIH/NIDDK B-ORG 1R01DK107666-01 O Department B-ORG of I-ORG Defence I-ORG W81XWH-16-1-0516 O and O National B-ORG Science I-ORG Foundation I-ORG SBIR O 1853207 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No.8206141056 O Science B-ORG and I-ORG Technology I-ORG Support I-ORG Plan I-ORG of I-ORG Guizhou I-ORG Province I-ORG No. O 2020]4Y066 B-AWARD Project B-ORG of I-ORG Administration I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG of I-ORG Guizhou I-ORG Province I-ORG QZYY-2019-010 O Postgraduate B-ORG Research I-ORG Fund I-ORG Project I-ORG of I-ORG Zunyi I-ORG Medical I-ORG University I-ORG ZYK81 O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Project O No. O 31873005 B-AWARD China B-ORG Agriculture I-ORG Research I-ORG System I-ORG Project O No. O CARS-36 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG Project O No. O 2017YFD0500901 B-AWARD This O study O was O supported O by O funds O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No O 81671958 B-AWARD and O 81902832 B-AWARD Science B-ORG and I-ORG Technology I-ORG Innovation I-ORG Talents I-ORG in I-ORG Henan I-ORG Universities I-ORG No O 19HASTIT003 B-AWARD Henan B-ORG Medical I-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Project I-ORG of I-ORG 2018 I-ORG No O SBGJ2018002 B-AWARD the B-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Project I-ORG of I-ORG Henan I-ORG Province I-ORG No O 192102310117 B-AWARD This O study O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31800055 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG LY18C060002 O and O Zhoushan B-ORG City-Zhejiang I-ORG University I-ORG Joint I-ORG Specific I-ORG Project I-ORG 2019C81055 O This O research O was O funded O by O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2015A020208020 O 2016A030303068 B-AWARD Special B-ORG Fund I-ORG for I-ORG Applied I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Meizhou I-ORG 2019B0201003 O and O Provincial B-ORG and I-ORG municipal I-ORG key I-ORG construction I-ORG projects I-ORG in I-ORG Jiaying I-ORG University I-ORG Promotion I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG in I-ORG Guangdong I-ORG Province I-ORG about I-ORG Key I-ORG Construction I-ORG Subjects I-ORG Agricultural O Resources O and O Environment O Guangdong O Science I-AWARD and I-AWARD education I-AWARD Letter I-AWARD 2018 I-AWARD NO.81 O The O research O was O supported O by O the O earmarked O fund O for O National B-ORG Modern I-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG CARS–28 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31501720 O Fruit B-ORG innovation I-ORG team I-ORG in I-ORG Shandong I-ORG Province I-ORG China I-ORG SDAIT-06-07 O and O joint B-ORG project I-ORG of I-ORG Shandong I-ORG Natural I-ORG Science I-ORG Foundation I-ORG China I-ORG ZR2014CL024 O R.A O M.S O P.B O and O K.M O were O supported O by O European O Regional O Development O Fund/European O Social O Fund O ERDF/ESF O project O PharmaBrain O no. O CZ.02.1.01/0.0/0.0/16_025/0007444 O University O of O Hradec O Kralove O no. O SV2113-2019 O VT2019-2021 O and O EU B-ORG COST I-ORG action O CA15135 B-AWARD MuTaLig O J.M.C O thanks O Ministerio O de O Economía O MINECO O SAF2015-65586-R B-AWARD and O Universidad O Camilo O José O Cela O UCJC O grants O UCJC B-AWARD 2020-03 O and O UCJC B-AWARD 2020-33 O for O support O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 20671064 O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Shenyang I-ORG City I-ORG No. O F12-277-1-52 B-AWARD Science B-ORG and I-ORG Technology I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province I-ORG 2015020485 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51675221 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Development I-ORG Planning I-ORG Project I-ORG of I-ORG Jilin I-ORG Province I-ORG of I-ORG China I-ORG No. O 20180101077JC B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Research I-ORG Project I-ORG in I-ORG the I-ORG 13th I-ORG Five-Year I-ORG Period I-ORG of I-ORG Education I-ORG Department I-ORG of I-ORG Jilin I-ORG Province I-ORG No. O JJKH20190134KJ B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O research O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51674050 O to O YPL O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG China I-ORG Grant O No. O 2016ZX05043005 B-AWARD I-AWARD 2016ZX05045004 O to O YPL O the O State B-ORG Key I-ORG Research I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2017YFC0804202 B-AWARD 2016YFC0801402 I-AWARD I-AWARD 2016YFC0801404 O to O YPL O the O Project B-ORG funded I-ORG by I-ORG China I-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Project O NO. O 2017M612916 B-AWARD to O JFH O the O Project B-ORG funded I-ORG by I-ORG Chongqing I-ORG Postdoctoral I-ORG Research I-ORG Foundation I-ORG Project O NO. O Xm2017068 B-AWARD to O JFH O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Project O No. O 106112015CDJZR245520 B-AWARD I-AWARD 106112017CDJXY240001 O to O YJL O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O Funds O of O Guangxi B-ORG Zhuang I-ORG Autonomous I-ORG Region I-ORG Health I-ORG and I-ORG Wellness I-ORG Committee I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG S201415-06 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangxi I-ORG China I-ORG Guikegong0861003 O Natural O Science O Foundation O of O Guangxi O China O 2017GXNSFAA198287 O Guangxi B-ORG Zhuang I-ORG Autonomous I-ORG Region I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG Self-Financed O Scientific O Research O Project O Z2012053 O Guangxi B-ORG Degree I-ORG and I-ORG Postgraduate I-ORG Education I-ORG Reform I-ORG and I-ORG Development I-ORG Research I-ORG Projects O China O JGY2019050 O Guangxi B-ORG Medical I-ORG University I-ORG Education I-ORG and I-ORG Teaching I-ORG Reform I-ORG Project I-ORG 2019XJGZ04 O Guangxi O Zhuang O Autonomous O Region O Health O and O Family O Planning O Commission O Self-financed O Scientific O Research O Project O Z20180979 O and O Guangxi B-ORG Zhuang I-ORG Autonomous I-ORG Region I-ORG University I-ORG Student I-ORG Innovative I-ORG Plan I-ORG No. O 201910598148 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31801745 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Chongqing O China O cstc2019jcyj-msxmX0403 O and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG XDJK2020B061 O This O work O was O supported O by O the O Fogarty B-ORG International I-ORG Center I-ORG of O the O National O Institutes O of O Health O Grant O number O D43TW010075 B-AWARD and O The O Wellcome B-ORG Trust I-ORG Grant O number O 107754/Z/15/Z B-AWARD National B-ORG Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases I-ORG Grant O number O K24AI114996 B-AWARD Funders O have O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81871367 B-AWARD the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Hunan I-ORG Province I-ORG China I-ORG No. O 2018SK21217 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG China I-ORG No. O 2021JJ31037 B-AWARD This O research O was O funded O by O the O Bill B-ORG and I-ORG Melinda I-ORG Gates I-ORG Foundation I-ORG OPP1035218 O OPP1174957 B-AWARD with O additional O support O from O the O Australian B-ORG Research I-ORG Council I-ORG Discovery O and O Linkage O Projects O DP160101429 O LP120100485 B-AWARD LE120100170 B-AWARD equipment O LE140100119 B-AWARD equipment O and O the O National B-ORG Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases O National O Institutes O of O Health O Department O of O Health O and O Human O Services O Federal O Contract O numbers O HHSH27220120025C B-AWARD HHSN272200700057C B-AWARD and O HHSN272201700059C B-AWARD The O authors O were O supported O by O research O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Funding O support O National O Natural O Science O Foundation O of O China O 81571311 O 81071099 B-AWARD and O 81271499 B-AWARD to O Y.T O 81725005 B-AWARD 81571331 B-AWARD to O F.W O National O Science O Fund O for O Distinguished O Young O Scholars O 81725005 O to O F.W O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2016YFC1306900 O to O Y.T O Liaoning B-ORG Education I-ORG Foundation I-ORG Pandeng O Scholar O F.W O National O Key O Research O and O Development O Program O 2016YFC0904300 O to O F.W O National B-ORG High I-ORG Tech I-ORG Development I-ORG Plan I-ORG 863 O 2015AA020513 O to O F.W O This O research O was O funded O by O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2018M640979 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 51875444 B-AWARD and O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2016YFB1100902 B-AWARD This O work O was O supported O by O grants O from O the B-ORG Chinese I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG HZ, O 81571957 B-AWARD Harbin B-ORG Medical I-ORG University I-ORG graduate I-ORG innovative I-ORG research I-ORG projects I-ORG QYL O YJSCX2016-2HYD B-AWARD and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Provincial I-ORG Universities I-ORG JW, O 2017-KYYWF-0297 B-AWARD MHC O 2019 O This O work O has O been O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos.11875226 O and O 11874306 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Chongqing I-ORG Grant O No. O CSTC-2017jcyjBX0035 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O Nos O XDJK2017C062 B-AWARD and O XDJK2017B020 B-AWARD and O the O educational O reform O Research O Funds O of O Southwest O Universities O Grant O No. O 2018JY0730 O This O work O was O supported O by O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG Grant O Number O 2016YFA0602703 B-AWARD Open B-ORG Fund I-ORG of I-ORG Key I-ORG Laboratory I-ORG of I-ORG Geospatial I-ORG Technology I-ORG for I-ORG the I-ORG Middle I-ORG and I-ORG Lower I-ORG Yellow I-ORG River I-ORG Regions I-ORG Henan I-ORG University I-ORG Ministry I-ORG of I-ORG Education I-ORG Grant O Number O GTYR201910 B-AWARD Program B-ORG of I-ORG Postgraduate I-ORG Education I-ORG Innovation I-ORG and I-ORG Quality I-ORG Improvement I-ORG in I-ORG Henan I-ORG University I-ORG Grant O Number O SYL19060114 B-AWARD C.-M.B O was O supported O by O the O Laboratory B-ORG for I-ORG Marine I-ORG Fisheries I-ORG Science I-ORG and I-ORG Food I-ORG Production I-ORG Processes O grant O number O 2016LMFS-B16 B-AWARD C.-M.W O was O supported O by O China B-ORG Agriculture I-ORG Research I-ORG System O grant O number O CARS-49 B-AWARD U.R O was O supported O by O a O biennial O grant O of O the O University B-ORG of I-ORG Padova O UNIPD-BIRD B-AWARD 168432 I-AWARD This O research O was O financial O supported O by O the O Natural B-ORG Sciences I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC I-ORG 71203203 O the O MOE B-ORG project I-ORG of I-ORG Humanities I-ORG and I-ORG Social I-ORG Sciences I-ORG 12YJCZH057 O and O the O Beijing B-ORG Higher I-ORG Education I-ORG Young I-ORG Elite I-ORG Teacher I-ORG Project I-ORG YETP0667 O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no.31270299 O and O 31200148 B-AWARD the O Program B-ORG for I-ORG New I-ORG Century I-ORG Excellent I-ORG Talents I-ORG in I-ORG University I-ORG of I-ORG China I-ORG NCET-11-0440 O and O Science B-ORG and I-ORG Technology I-ORG Office I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2012C12901-2 O This O work O was O supported O by O the O Major B-ORG National I-ORG Research I-ORG and I-ORG Development I-ORG Projects I-ORG 2012ZX10001005-007 O the O National B-ORG High I-ORG Technology I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2012AA02A404 O and O the O State B-ORG Key I-ORG Laboratory I-ORG for I-ORG Infectious I-ORG Disease I-ORG Prevention I-ORG and I-ORG Control I-ORG 2011SKLID103 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2022YFC2702901 O The O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 82273639 O The O University B-ORG Synergy I-ORG Innovation I-ORG Program I-ORG of I-ORG Anhui I-ORG Province I-ORG GXXT-2020-067 O The O Non-profit B-ORG Central I-ORG Research I-ORG Institute I-ORG Fund I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Medical I-ORG Sciences I-ORG 2019PT310002 O Research B-ORG Fund I-ORG of I-ORG Anhui I-ORG Institute I-ORG of I-ORG Translational I-ORG Medicine I-ORG ZHYX2020A001 O This O study O was O supported O by O BE-Basic B-ORG Foundation-FES I-ORG No. O F07.003.06 B-AWARD Vietnam B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG No. O ĐTĐLCN.17/14 B-AWARD MC-ITN-BluePharmTrain B-ORG No. O 607786 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Science I-ORG Foundation I-ORG 1648822 O the O National B-ORG Eye I-ORG Institute I-ORG R01EY025687 O R01EY032342 B-AWARD P30EY025585 B-AWARD and O T32 B-AWARD EY024236 O and O the O National B-ORG Multiple I-ORG Sclerosis I-ORG Society I-ORG FG-1807-31882 O and O FG-2108-38411 B-AWARD Author O Chunbo O Chen O is O currently O receiving O a O grant O #2014001 O from O the O Guangdong B-ORG Province I-ORG Hospital I-ORG Association I-ORG Scientific I-ORG Research I-ORG Foundation I-ORG and O a O grant O #201343 O from O the O Guangdong B-ORG General I-ORG Hospital I-ORG Scientific I-ORG Research I-ORG Foundation O author O Bo O Lv O is O currently O receiving O a O grant O #2013B021800158 O from O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province O China O author O Bei O Hu O is O currently O receiving O a O grant O #2014A020212236 O from O the O Science O and O Technology O Planning O Project O of O Guangdong O Province O China O The O funding O sources O played O no O role O in O the O design O of O the O study O and O collection O analysis O or O interpretation O of O data O and O played O no O role O in O the O drafting O revision O or O submission O of O the O manuscript O This O research O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province O No. O GG22E081947 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Ningbo I-ORG NO. O 2019C10037 O 2021J142 B-AWARD and O Key B-ORG laboratory I-ORG of I-ORG yarn I-ORG material I-ORG forming I-ORG and I-ORG composite I-ORG processing I-ORG technology I-ORG Zhejiang I-ORG Province I-ORG No. O MTC2021-09 B-AWARD And O The O APC O was O funded O by O Zhejiang O Institute O of O Tianjin O University O Funding O was O provided O by O the O Swedish B-ORG Research I-ORG Council I-ORG grant O 2019-03706 B-AWARD Formas B-ORG grant O 2021-01096 B-AWARD Crafoord B-ORG Foundation I-ORG grant O 20220602 B-AWARD and O the O Royal B-ORG Physiographical I-ORG Society I-ORG of I-ORG Lund I-ORG grants O 42305 B-AWARD 41593 B-AWARD to O S.P.D O This O research O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2016YFD0400102 O to O KC O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31722042 O 31672204 B-AWARD to O XY O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG China I-ORG LR16C150001 O to O XY O the O Fundamental O Research O Funds O for O the O Central O Universities O and O the O 111 B-ORG Project I-ORG B17039 O to O XY O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG China I-ORG Grant O No. O ZR2019MC071 B-AWARD the O Shandong B-ORG Agricultural I-ORG Good I-ORG Cultivar I-ORG Project I-ORG Grant O No. O 2016LZGC034 B-AWARD and O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG of I-ORG SAAS I-ORG CXGC2016A03 O and O CXGC2018F03 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Shanghai B-ORG Municipal I-ORG Key I-ORG Specialty I-ORG Construction I-ORG Fund I-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Health I-ORG Bureau I-ORG grant O no. O ZK2015A14 B-AWARD Shanghai B-ORG Municipal I-ORG Planning I-ORG Commission I-ORG Fund I-ORG grant O no. O 20134394 B-AWARD and O Shanghai B-ORG Pudong I-ORG New I-ORG Area I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Fund I-ORG grant O no. O PKJ2013-Y40 B-AWARD This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 62205082 B-AWARD 62104053 B-AWARD 62174063 B-AWARD 62105349 B-AWARD Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG Grant O Nos O 22ZR1472300 B-AWARD and O 21ZR1473400 B-AWARD China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG Grant O No. O 2021M700156 B-AWARD and O open O fund O of O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Infrared I-ORG Physics I-ORG Grant O No. O SITP-NLIST-ZD-2022-02 B-AWARD Oscar O Flores-Flores O was O supported O by O NIH O Research O Training O Grant O O D43 B-AWARD TW009340 I-AWARD funded O by O the O NIH O Fogarty B-ORG International I-ORG Center O NINDS O NIMH O and O NHBLI O Suzanne O Pollard O was O supported O by O a O Mentored O Research O Scientist O Development O Award O 1K01HL140048 O from O the O National B-ORG Heart I-ORG Lung I-ORG and I-ORG Blood I-ORG Institute O National O Institutes O of O Health O The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O National O Institutes O of O Health O The O parent O GECo O Global O Excellence O in O Chronic O Obstructive O Pulmonary O Disease O Outcomes O study O was O supported O by O the O UK B-ORG Medical I-ORG Research I-ORG Council I-ORG MR/P008984/1 O PI: O Hurst O under O the O Global O Alliance O for O Chronic O Disease O Supported O by O the O Biological B-ORG Physical I-ORG Sciences I-ORG Institute I-ORG Royal I-ORG Society I-ORG MRC I-ORG grant O MR/K01580X/1 B-AWARD BBSRC B-ORG grant O BB/N006453/1 B-AWARD Swedish B-ORG Research I-ORG Council I-ORG and I-ORG European I-ORG Commission I-ORG via I-ORG Marie I-ORG Curie-Network I-ORG for I-ORG Initial I-ORG training I-ORG ISOLATE I-ORG Grant O agreement O nr: O 289995 B-AWARD and O the O Marie O Curie O Alumni O Association O This O project O was O supported O by O the O Open B-ORG Research I-ORG Fund I-ORG Program I-ORG of I-ORG the I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Virology I-ORG of I-ORG China I-ORG Grant O number O 2018KF005 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China-Xinjiang I-ORG joint I-ORG fund I-ORG Grant O number O U1403222 B-AWARD and O the O Health B-ORG Commission I-ORG of I-ORG Hubei I-ORG Province I-ORG scientific I-ORG research I-ORG project I-ORG Grant O number O 2019H074 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O São B-ORG Paulo I-ORG Research I-ORG Foundation I-ORG FAPESP O grant O 2018/15559-7 B-AWARD This O study O was O possible O thanks O to O the O scholarship O granted O from O the O Brazilian O National B-ORG Council I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Development I-ORG CNPq O grant O 142555/2019-3 B-AWARD in O the O scope O of O the O Program O CAPES-PrInt B-ORG process O number O 88881.310312/2018-01 B-AWARD This O work O was O supported O by O the O China B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG Project I-ORG 2016YFC1401403 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U1901213 B-AWARD 41466010 I-AWARD 41676008 O International B-ORG Science I-ORG and I-ORG Technology I-ORG Cooperation I-ORG Programme I-ORG GASI-IPOVAI-04 B-AWARD Guangdong O Natural O Science O Foundation O of O China O 2016A030312004 O and O the O Project O of O Enhancing O School O with O Innovation O of O Guangdong O Ocean O University O GDOU2016050260 O This O work O was O partly O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 81573708 B-AWARD the B-ORG Guangdong I-ORG Natural I-ORG Science I-ORG Funds I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG grant O number O 2015A030306049 B-AWARD the B-ORG Discipline I-ORG of I-ORG Integrated I-ORG Chinese I-ORG and I-ORG Western I-ORG Medicine I-ORG in I-ORG Guangzhou I-ORG University I-ORG of I-ORG Chinese I-ORG Medicine I-ORG grant O number O YN2015MS21 B-AWARD YN2019MJ15 O and O Special B-ORG support I-ORG plan I-ORG for I-ORG training I-ORG high I-ORG level I-ORG talents I-ORG in I-ORG Guangdong I-ORG Province I-ORG 2015TQ01R588 O The O funding O source O has O no O involvement O in O study O design O in O the O collection O analysis O and O interpretation O of O data O in O the O writing O of O the O report O and O in O the O decision O to O submit O the O article O for O publication O This O work O was O supported O by O Grants O from O the O program O for O Yong B-ORG Talents I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG in I-ORG Universities I-ORG of I-ORG Inner I-ORG Mongolia I-ORG Autonomous I-ORG Region I-ORG No. O NJYT-19-A14 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81560677 B-AWARD 31560443 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Inner I-ORG Mongolia I-ORG 2019MS03019 O The O authors O thank O the B-ORG China I-ORG Scholarship I-ORG Council I-ORG for O financial O support O to O YW O No. O 201808155035 B-AWARD The O work O was O sponsored O by O the O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG grant O no. O BB/M022994/1 B-AWARD C.P O M.J.K O and O John O Bertrand O Gurdon O The O Gurdon O laboratory O is O funded O by O the O grant O 101050/Z/13/Z B-AWARD John O Bertrand O Gurdon O from O the O Wellcome B-ORG Trust O The O Gurdon O Institute O is O supported O by O core O grants O namely O by O the O Wellcome O Trust O Core O grant O no. O 203144 O and O by O the O Cancer B-ORG Research I-ORG UK I-ORG Grant O C6946/A24843 O This O study O was O funded O by O the O Norway–Romania B-ORG Grants O RO-NO-2019-0510 B-AWARD CTR B-AWARD 41/2021 I-AWARD to O D.I.S O by O 46PD/7.08.2020 B-AWARD to O M.T O by O the O Romanian B-ORG Ministry I-ORG of I-ORG Education I-ORG and I-ORG Research I-ORG grant O no. O PN B-AWARD 19060203/2019 I-AWARD to O D.I.S O and O M.T O and O by O Parkinson’s B-ORG UK I-ORG grant I-ORG K-1901 B-AWARD to O N.M O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O number O 51675429 B-AWARD Key O Project O of O National O Natural O Science O Foundation O of O China O grant O number O 51535009 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities O grant O number O 31020190503004 B-AWARD and O the O 111 B-ORG Project O grant O number O B13044 B-AWARD The O work O was O supported O by O the O EuroHOPE B-ORG Research I-ORG Grant I-ORG 241721 O financed O by O the O European O Union O belonging O into O the O seventh O Framework O Program O FP7 O of O the O European O Commission O to O IS, O DB, O JL, O EB, O UH O and O IV O It O was O also O supported O by O grants O from O the O National B-ORG Brain I-ORG Research I-ORG Program I-ORG KITA-NAP-13-1-2013-0001 O to O DB O the O Higher B-ORG Education I-ORG Institutional I-ORG Excellence I-ORG Program I-ORG and I-ORG the I-ORG New I-ORG National I-ORG Excellence I-ORG Program I-ORG UNKP-17-3 O to O DB) O of O the O Ministry O of O Human O Resources O of O the O Government O of O Hungary O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundations I-ORG of I-ORG China I-ORG 81470663 O Clinical B-ORG Research I-ORG Plan I-ORG of I-ORG SHDC I-ORG 12016223 O Shanghai B-ORG Jiao I-ORG Tong I-ORG University I-ORG Biomedical I-ORG Engineering I-ORG Research I-ORG Fund I-ORG YG2016QN03 O and O the B-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG 17DZ2260100 O They O supported O in O the O data O collection O and O analysis O results O interpretation O and O manuscript O revision O This O study O was O financially O supported O by O grants O from O the B-ORG Shijiazhuang I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG Foundation I-ORG Grant O no. O 171461553 B-AWARD Key B-ORG Research I-ORG of I-ORG Medical I-ORG Science I-ORG Research I-ORG of I-ORG Hebei I-ORG Province O China O Grant O no. O 20190165 B-AWARD and O Special B-ORG Project I-ORG of I-ORG Beijing-Tianjin-Hebei I-ORG Basic I-ORG Research I-ORG Cooperation I-ORG Grant O no. O H2019106063 B-AWARD This O research O was O supported O by O the O grants O from O the O Russian B-ORG Foundation I-ORG for I-ORG Basic I-ORG Research I-ORG 19-04-00352 O D.A.M O and O D.E.K O Russian B-ORG Program I-ORG for I-ORG Basic I-ORG Research I-ORG 0310-2019-0003 O D.E.K O and O 0310-2019-0005 B-AWARD D.A.M O and O the O grant O from O the O Ministry B-ORG of I-ORG Education I-ORG and I-ORG Science I-ORG of I-ORG Russian I-ORG Federation I-ORG 14.Y26.31.0024 B-AWARD D.A.M O The O Safer O Conception O Intervention O for O Partners O SCIP O study O was O funded O by O the O Eunice O Kennedy O Shriver O National B-ORG Institute I-ORG for I-ORG Child I-ORG Health I-ORG and I-ORG Human I-ORG Development I-ORG of I-ORG the I-ORG US I-ORG National I-ORG Institutes I-ORG of I-ORG Health I-ORG grant O R00 B-AWARD HD076679 O and O the O Fogarty B-ORG International I-ORG Center I-ORG grant O R21 B-AWARD TW009908 O JV O was O supported O by O the O National B-ORG Institute I-ORG of I-ORG Mental I-ORG Health I-ORG of I-ORG the I-ORG US I-ORG National I-ORG Institutes I-ORG of I-ORG Health I-ORG grant O F31 B-AWARD MH113420 O and O the O University O of O Washington O Department O of O Global O Health’s O Global O Opportunities O GO) O Health O Fellowship O Gilead O Sciences O donated O the O PrEP O medication O but O had O no O role O in O data O collection O or O analysis O The O funding O sources O had O no O role O in O the O design O or O conduct O of O the O study O collection O analysis O or O interpretation O of O the O data O preparation O review O or O approval O of O the O manuscript O or O the O decision O to O submit O the O manuscript O for O publication O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81570033 B-AWARD 81570047 I-AWARD 81470227 I-AWARD 81370145 I-AWARD 81370156 I-AWARD 81670035 O National B-ORG key I-ORG basic I-ORG research I-ORG and I-ORG development I-ORG program I-ORG 973 O Program O No. O 20l5CB553403 B-AWARD Chinese B-ORG medical I-ORG association I-ORG research I-ORG project I-ORG No. O 2013BAI09B00 B-AWARD National B-ORG Key I-ORG Technologies I-ORG R&D I-ORG Program I-ORG 2016YFC1303900 O and I-AWARD 2016YFC1304700 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG in I-ORG China I-ORG 2016YFC0903600 O and O Changjiang B-ORG Scholars I-ORG and I-ORG Innovative I-ORG Research I-ORG Team I-ORG in I-ORG University I-ORG No. O IRT_14R20 O The O ARCHER O study O is O supported O by O an O Australian B-ORG National I-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG Project I-ORG Grant I-ORG #1003312 O The O authors O gratefully O acknowledge O the O Sydney B-ORG Medical I-ORG School’s I-ORG Medical I-ORG Foundation I-ORG Grant I-ORG No. O 999 B-AWARD that O supported O the O initial O feasibility O studies O An O Australian B-ORG Rotary I-ORG District I-ORG 9650 I-ORG Youth I-ORG Depression I-ORG Grant I-ORG No. O 9650 O supported O the O final O feasibility O study O for O the O ARCHER O study O This O work O was O supported O by O research O grants O from O the O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2013CB967503 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81570854 O and O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG 16411953700 O The O funding O organisations O had O no O role O in O collection O analysis O or O interpretation O of O data O or O in O writing O of O the O manuscript O This O work O conducted O through O the O SERAPIS O project O was O supported O by O the O Regional B-ORG Council I-ORG of I-ORG Lower I-ORG Normandy I-ORG grant O number O 12P03057 B-AWARD the O Regional B-ORG Council I-ORG of I-ORG Brittany I-ORG grant O number O 12008011 B-AWARD and O the O European B-ORG Regional I-ORG Development I-ORG Fund I-ORG grant O number O 33525 B-AWARD SK's O research O is O supported O by O the O Deutsche B-ORG Forschungsgemeinschaft I-ORG EXC O 1028 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O Centre O Mondial O d’Innovation O – O Groupe O Roullier O provided O support O in O the O form O of O salaries O for O authors O MA, O FC O and O JCY O as O well O as O the O PhD O grant O of O ES, O but O did O not O have O any O additional O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O specific O roles O of O these O authors O are O articulated O in O the O ‘author O contributions’ O section O VEGENOV-BBV O provided O support O in O the O form O of O salary O for O author O MT, O but O did O not O have O any O additional O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O specific O role O of O this O author O is O articulated O in O the O ‘author O contributions O section O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81930020 O 81603035 B-AWARD and I-AWARD 81870599 O China B-ORG Postdoctoral I-ORG Fellowship I-ORG 2017M612981 O Young B-ORG Scientist I-ORG Fellowship I-ORG of I-ORG Sichuan I-ORG University I-ORG 2017SCU11026 O and O Postdoctoral B-ORG Fellowship I-ORG of I-ORG Sichuan I-ORG University I-ORG 2017SCU12036 O This O work O was O supported O by O the O Yunnan B-ORG Key I-ORG R&D I-ORG Program I-ORG 2018ZF007-02 O and O 2018FA008 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFA0108500 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31760268 O and O 81660266 B-AWARD the O Yunnan B-ORG Provincial I-ORG Innovation I-ORG Team I-ORG 2018HC003 O and O Yunnan B-ORG Fundamental I-ORG Research I-ORG Projects I-ORG 2019FY002 O This O work O was O supported O by O European B-ORG Research I-ORG Council I-ORG grant O ORCA B-AWARD FP7-PEOPLE-2011-IIF I-AWARD 299075 I-AWARD to O M.H O and O M.C O PIs O and O Labex B-ORG Archimede I-ORG programme I-ORG IA- B-AWARD ANR-11-LABX-0032-01 I-AWARD at O the O University O Paul-Valéry O Montpellier O 3 O A.G O A.R O and O A.C O were O financially O supported O by O the O Project O MORSE O CEP&S O 2011-ANR-279 I-AWARD 11-CEPL-006 O French B-ORG National I-ORG Research I-ORG Agency O and O by O the O project O ‘Y O a-t-il O eu O une O exploitation O ancienne O des O baleines O en O Méditerranée?’ O Maison O des O Sciences O de O l'Homme O de O Montpellier O along O with O A.G O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 61575176 B-AWARD the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 O Program O grant O number O 2013CB632104 B-AWARD the O Research B-ORG Foundation I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Modern I-ORG Optical I-ORG Instrumentation I-ORG grant O number O MOI201701 B-AWARD This O work O was O supported O by O the O 1.3.5 O project O for O disciplines O of O excellence O West B-ORG China I-ORG Hospital I-ORG Sichuan I-ORG University I-ORG No. O ZYGD20009 B-AWARD Sichuan B-ORG Science I-ORG and I-ORG Technological I-ORG Program I-ORG No. O 2022YFS0338 B-AWARD the O Post-Doctor O Research O Project O of O West B-ORG China I-ORG Hospital I-ORG of I-ORG Sichuan I-ORG University I-ORG No. O 2020HXBH079 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81900512 B-AWARD This O research O was O supported O by O Discipline O construction O fund O project O of O Gansu O Agricultural O University O GAU-XKJS-2018-225 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31260311 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Gansu I-ORG Province I-ORG 1606RJZA034 O and O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2012M512042 O and I-AWARD 2014T70942 O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-09-P14 O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No O 82004168 B-AWARD 81973567 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG Project I-ORG of I-ORG Chongqing I-ORG Grant O No O cstc2019jcyj-msxmX0180 B-AWARD Science B-ORG and I-ORG Technology I-ORG Research I-ORG Program I-ORG of I-ORG Chongqing I-ORG Municipal I-ORG Education I-ORG Commission I-ORG Grant O No O KJQN202215101 B-AWARD Program B-ORG of I-ORG Chongqing I-ORG Health I-ORG Commission I-ORG Grant O No O 2019ZY3503 B-AWARD CQMU B-ORG Program I-ORG for I-ORG Youth I-ORG Innovation I-ORG in I-ORG Future I-ORG Medicine I-ORG Grant O No O W0066 B-AWARD and O Xinglin B-ORG program I-ORG of I-ORG Chongqing I-ORG TCM/TCM-integrated I-ORG Key I-ORG discipline I-ORG Grant O No O 2021-ZDXK-yc03 B-AWARD This O work O was O supported O by O Instituto B-ORG Antártico I-ORG Chileno I-ORG project O INACH B-AWARD G_06-10 O Fondecyt B-ORG Grant O 11090192 B-AWARD and O DICYT-USACH O CGD O has O received O doctoral O fellowship O CONICYT-PFCHA/Doctorado B-ORG Nacional/2014-63140056 O The O funders O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O supported O by O the O Graduate B-ORG Research I-ORG and I-ORG Innovation I-ORG Foundation I-ORG of I-ORG Chongqing O China O CYB18032 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51474039 O 51404046 O the O Chongqing O University O Postgraduates’ O Innovation O Project O CYS15007 O and O the O Basic B-ORG Research I-ORG of I-ORG Frontier I-ORG and I-ORG Application I-ORG of I-ORG Chongqing I-ORG cstc2015jcy O jA90019 I-AWARD cstc2016jcyjA0085 O This O study O was O supported O by O the O Jiangsu B-ORG Young I-ORG Medical I-ORG Talents I-ORG Project I-ORG QNRC2016269 O the B-ORG Applied I-ORG Basic I-ORG Research I-ORG Fund I-ORG of I-ORG Changzhou I-ORG China I-ORG Grant O no. O CJ20140022 B-AWARD the B-ORG High-level I-ORG Medicine I-ORG Talents I-ORG Training I-ORG Project I-ORG 2016CZBJ022 O and O the B-ORG Youth I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Changzhou I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG QN201601 O This O work O was O co-funded O by O the O project O NORTE-01-0246-FEDER-000063 O supported O by O Norte B-ORG Portugal I-ORG Regional I-ORG Operational I-ORG Programme I-ORG NORTE2020 O under O the O PORTUGAL O 2020 O Partnership O Agreement O through O the O European O Regional O Development O Fund O ERDF O FCT O also O supported O the O post-doctoral O fellowships O of O AP B-ORG SFRH/BPD/117451/2016 O and O the O Investigator O grant O of O PJE B-ORG CEECIND/CP1601/CT0005 O This O work O was O supported O by O ‘Twelve-Five O National I-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG of I-ORG China’ O Grant O No. O 2014BAD16B07 B-AWARD I-AWARD 2014BAD23B01 O to O WS; O ‘National O Li I-ORG Chanye I-ORG Jishu I-ORG Tixi I-ORG of I-ORG China’ O Grant O No.CARS-29-05B O to O WS, O ‘International O Science I-ORG and I-ORG Technology I-ORG Cooperation I-ORG Program I-ORG of I-ORG China’ O Grant O No.2015DFR30290 O to O WS. O This O work O was O supported O by O National B-ORG Major I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG for I-ORG Water I-ORG Pollution I-ORG Control I-ORG and I-ORG Treatment I-ORG No. O 2017ZX07101-002 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2016SHXY06 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51609271 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Core B-ORG Research I-ORG for I-ORG Evolutional I-ORG Science I-ORG and I-ORG Technology I-ORG CREST O from O Japan O Science O and O Technology O Agency O JST)/Japan O Agency I-ORG for I-ORG Medical I-ORG Research I-ORG and I-ORG Development I-ORG AMED O Grant O number O 17gm0710001h0105 B-AWARD Recipient O Junken O Aoki O Leading O Advanced O Projects O for O medical O innovation O LEAP O from O the O Japan O Agency O for O Medical O Research O and O Development O AMED O Grant O number O 17gm0010004s0101 B-AWARD Recipient O Junken O Aoki O Grant-in-Aid O for O Scientific O Research O on O Innovative O Areas O from O Japan B-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG JSPS O Grant O number O 15H05906 B-AWARD Recipient O Yutaka O Yatomi O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 31771330 O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC0110602 O and O Guangdong B-ORG and I-ORG Guangzhou I-ORG provincial I-ORG scientific I-ORG and I-ORG technique I-ORG program I-ORG 2014A020212200 O 2015A040404022 I-AWARD 2015B010125006 I-AWARD 2015B010125005 I-AWARD 201704020129 I-AWARD and I-AWARD 201704020069 O This O work O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 52174281 O the O Hebei B-ORG Province I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Innovation I-ORG Group I-ORG Project I-ORG B2021203016 O and O the O Hebei B-ORG Key I-ORG Laboratory I-ORG of I-ORG Applied I-ORG Chemistry I-ORG 22567616H O The O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 81490534 B-AWARD NZ O and O HZ O 81770079(YL B-AWARD and O 81370177 B-AWARD HZ O by O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG No. O 2017ZX10204401003 B-AWARD by O the B-ORG Chief I-ORG Scientist I-ORG Project I-ORG of I-ORG Yangcheng I-ORG Scholar I-ORG in I-ORG Guangzhou I-ORG Grant O No. O 1201541642 B-AWARD and O Canadian B-ORG Institute I-ORG of I-ORG Health I-ORG Research I-ORG FDN143285 O and O CCl132569 B-AWARD Dr. O Burns O holds O a O Merit O Award O from O the O University O of O Toronto O Toronto O Canada O This O research O was O funded O by O Pro B-ORG Hallmarks I-ORG Taiwan I-ORG Ltd I-ORG grant O number O A-108-040 B-AWARD MacKay B-ORG Memorial I-ORG Hospital O grant O number O MMH-111-99 B-AWARD and O the B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Taiwan O grant O number O 107-2218-E-992-001-MY2 B-AWARD National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2019YFC0312601 B-AWARD National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG for I-ORG Significant I-ORG New I-ORG Drugs I-ORG Development I-ORG No. O 2018ZX09735004 B-AWARD the O National B-ORG Laboratory I-ORG Director I-ORG Fund I-ORG QNLM201709 O the O grant O from O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 201762011 O and O 201941012 B-AWARD and O the O Marine B-ORG S&T I-ORG Fund I-ORG of I-ORG Shandong I-ORG Province I-ORG for I-ORG Pilot I-ORG National I-ORG Laboratory I-ORG for I-ORG Marine I-ORG Science I-ORG and I-ORG Technology I-ORG Qingdao O No. O 2018SDKJ0402 B-AWARD and O by O the O Major B-ORG Scientific I-ORG Research I-ORG Platform I-ORG Construction I-ORG Project I-ORG of I-ORG Shandong I-ORG Province I-ORG No. O 2018SDPT01 B-AWARD This O research O was O supported O by O GE B-ORG Healthcare I-ORG Company I-ORG Chicago I-ORG IL, I-ORG USA I-ORG 10224776 O the O University B-ORG of I-ORG Southern I-ORG Denmark I-ORG 19/1435 O and O Odense B-ORG University I-ORG Hospital I-ORG Denmark I-ORG 10212315 O This O project O was O financially O supported O in O part O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG U1603108 O China B-ORG Agriculture I-ORG Research I-ORG System-Bee I-ORG NYCYTX-44-KXJ5 O and O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG CAAS-ASTIP-2023-IAR O This O work O was O funded O byChinese O Medicine I-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Provincegrant2018ZB076;the O Medical I-ORG and I-ORG Health I-ORG Technology I-ORG Development I-ORG Program I-ORG of I-ORG Hangzhougrant2014A62;the O Medical I-ORG and I-ORG Health I-ORG Technology I-ORG Development I-ORG Program I-ORG of I-ORG Zhejiang I-ORG Provincegrant2018KY462 O This O work O was O supported O by O ANID B-ORG FONDECYT I-ORG 11190756 B-AWARD A.d.C O and O 1191078 B-AWARD R.T O Project B-ORG SOCHED I-ORG N° O 2021-06 B-AWARD N.J O and O ANID B-ORG FONDEQUIP I-ORG EQM160042 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31701159 B-AWARD Harbin B-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG Project I-ORG No. O 2017RAQXJ131 B-AWARD and O Fundamental B-ORG Research I-ORG Service I-ORG Fundamental I-ORG Research I-ORG Project I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG No. O KJCX201815 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O primarily O funded O by O grants O of O Chinese B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS29-bc-4 O Fundamental B-ORG Research I-ORG Funds I-ORG of I-ORG CAAS I-ORG Y2022LM23 O and O Chinese B-ORG Scholarship I-ORG Council I-ORG No. O 202103250079 B-AWARD The O study O was O financially O supported O by O the O Slovenian B-ORG Research I-ORG Agency I-ORG through O research O core O funding O P2-0103 B-AWARD and O P5-0093 B-AWARD as O well O as O project O N2-0056 B-AWARD Machine O Learning O for O Systems O Sciences O the O Slovenian B-ORG Ministry I-ORG of I-ORG Education I-ORG Science I-ORG and I-ORG Sport I-ORG through O funding O agreement O C3330-17-529020 B-AWARD and O the O European B-ORG Commission I-ORG through O grants O MAESTRA B-AWARD HBP B-AWARD SGA2 O and O LANDMARK B-AWARD This O research O work O is O supported O by O the O Collaborative O Research O Project O entitled O Video O Processing O and O Transmission O by O the O JICA B-ORG Project I-ORG for I-ORG AUN/SEED-Net I-ORG Japan I-ORG Thailand I-ORG Science I-ORG research I-ORG and I-ORG Innovation I-ORG Fund I-ORG Chulalongkorn I-ORG University I-ORG CU_FRB65_ind O 9)_157_21_23 O IND66210019 O the O NSRF O via O the O Program B-ORG Management I-ORG Unit I-ORG for I-ORG Human I-ORG Resources I-ORG Institutional I-ORG Development I-ORG Research I-ORG and I-ORG Innovation I-ORG grant O number O B04G640053 B-AWARD and O Ratchadaphiseksomphot B-ORG Endowment I-ORG Fund I-ORG Multimedia O Data I-AWARD Analytics I-AWARD and I-AWARD Processing I-AWARD Research I-AWARD Unit O This O paper O is O partially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Serial O No.61602174 O and O 61563016 O the O Jiangxi B-ORG Provincial I-ORG natural I-ORG science I-ORG fund I-ORG No. O 20161BAB212052 B-AWARD and O 20151BAB217011 O and O the B-ORG Scientific I-ORG and I-ORG Technological I-ORG Research I-ORG Project I-ORG of I-ORG Education I-ORG Department I-ORG in I-ORG Jiangxi I-ORG Province(GJJ150496 O This O work O is O also O supported O by O Hunan O Province O high O school O Scientific O Research O Project O Grant O No. O 12C1093 O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81374050 O National B-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG Projects I-ORG 2014BA105B01 O PCSIRT B-ORG IRT-14R41 O and O State O the O Science O O Technology O Commission O of O MOST O of O China O 2014ZX09304307001 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Consejería B-ORG de I-ORG Economía I-ORG Ciencia I-ORG y I-ORG Empresa I-ORG of I-ORG the I-ORG Junta I-ORG de I-ORG Andalucía I-ORG CTS O 2027 B-AWARD Subprograma B-ORG Miguel I-ORG Servet I-ORG from I-ORG the I-ORG Ministerio I-ORG de I-ORG Economía I-ORG y I-ORG Competitividad I-ORG of I-ORG Spain I-ORG CPII16/00061 O Subprograma B-ORG Sara I-ORG Borrell I-ORG CD14/00014 O Spanish B-ORG Network I-ORG for I-ORG the I-ORG Research I-ORG in I-ORG Infectious I-ORG Diseases I-ORG REIPI O RD06/0008/0000 O This O study O was O financially O supported O by O Changzhou B-ORG Social I-ORG Development I-ORG Project I-ORG Grant O No. O CE20185002 B-AWARD Jiangsu B-ORG social I-ORG development I-ORG project I-ORG No. O BE2016663 B-AWARD Zhangjiagang B-ORG science I-ORG and I-ORG technology I-ORG planned I-ORG project I-ORG ZKS1703 O Research B-ORG Funds I-ORG of I-ORG Jiangsu I-ORG Entry-Exit I-ORG Inspection I-ORG and I-ORG Quarantine I-ORG Bureau I-ORG No. O 2018KJ07 B-AWARD The O research O was O supported O by O grants O from O the O Youth B-ORG Project I-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG No. O 02.2162 O Shanghai B-ORG Academic/Technology I-ORG Research I-ORG Leader I-ORG Program I-ORG No.2018BR32 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81602062 O No. B-AWARD 81872242 O No. B-AWARD 81802890 O and O No. B-AWARD 81871923 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shanghai I-ORG 18ZR1436900 O This O work O was O supported O by O the O Indian B-ORG Council I-ORG of I-ORG Medical I-ORG Research I-ORG ICMR O New O Delhi O India O grant O number O TRIBAL/70/2013-ECD-II B-AWARD http://icmrextramural.in/ICMR O and O Manipal B-ORG Academy I-ORG of I-ORG Higher I-ORG Education I-ORG MAHE O Manipal O India O intramural O grant O number O FNE0131 B-AWARD https://manipal.edu/mu.html O provided O to O RSS O SG O was O supported O by O Innovation B-ORG in I-ORG Science I-ORG Pursuit I-ORG for I-ORG Inspired I-ORG Research I-ORG INSPIRE O fellowship O Department O of O Science O and O Technology O IF150647 O http://www.inspire-dst.gov.in O KS O gratefully O acknowledges O infrastructure O support O from O FIST O Government O of O India O http://www.fist-dst.org O K-FIST O Government O of O Karnataka-https://www.karnataka.gov.in/ksteps/Pages/K-FIST.aspxand O TIFAC-CORE O in O Pharmacogenomics O https://www.tifac.org.in O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Shanghai B-ORG Key I-ORG Lab I-ORG of I-ORG Forensic I-ORG Medicine I-ORG Ministry I-ORG of I-ORG Justice O China O Academy O of O Forensic O Science O grant O number O KF202113 B-AWARD the O Youth B-ORG Medical I-ORG Talents-Medical I-ORG Imaging I-ORG Practitioner I-ORG Program I-ORG grant O number O AB83030002019004 B-AWARD Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Shanghai I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG grant O number O 22Y11910700 B-AWARD the O Health B-ORG Commission I-ORG of I-ORG Shanghai I-ORG grant O number O 2018ZHYL0103 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 61976238 B-AWARD and O Shanghai B-ORG “Rising I-ORG Stars I-ORG of I-ORG Medical I-ORG Talent” I-ORG Youth I-ORG Development I-ORG Program I-ORG “Outstanding I-ORG Youth I-ORG Medical I-ORG Talents” I-ORG SHWJRS O 2021]-99 O Emerging B-ORG Talent I-ORG Program I-ORG XXRC2213 O and O Leading B-ORG Talent I-ORG Program I-ORG LJRC2202 O of O Huadong O Hospital O and O Excellent B-ORG Academic I-ORG Leaders I-ORG of I-ORG Shanghai I-ORG 2022XD042 O This O work O was O funded O by O Grants O from O the O National B-ORG Science I-ORG Foundation I-ORG MCB-9874744 O and O the O U.S B-ORG Department I-ORG of I-ORG Agriculture I-ORG 2004-34490-14579 O and O partially O by O the O U.S B-ORG Department I-ORG of I-ORG Energy I-ORG Office I-ORG of I-ORG Science I-ORG Basic I-ORG Energy I-ORG Sciences O grant O number O DE-SC0015662 B-AWARD This O study O was O supported O by O the O European B-ORG Union I-ORG under O the O action O of O the O ERA-NET O COFUND O 2019-2.1.7-ERANET-2021-00018 O to O B.V O by O the O Hungarian B-ORG Brain I-ORG Research I-ORG Program I-ORG 2 O 2017-1.2.1.-NKP-2017 O to O B.V O by O NKFIH B-ORG OTKA O NN128293 O to O B.V O as O well O as O OTKA B-AWARD K134555 I-AWARD to O A.B O E.C O and O K.A O by O the O European B-ORG Union I-ORG and I-ORG the I-ORG State I-ORG of I-ORG Hungary I-ORG cofinanced I-ORG by I-ORG the I-ORG European I-ORG Social I-ORG Fund I-ORG in O the O framework O of O TAMOP-4.2.4.A/2-11/1-2012-0001 B-AWARD National O Excellence O Program O B.V O by O the O ÚNKP-20-1-I-PTE-801 O New B-ORG National I-ORG Excellence I-ORG Program I-ORG of I-ORG the I-ORG Ministry I-ORG for I-ORG Innovation I-ORG and I-ORG Technology I-ORG to O B.B O by O the O ÚNKP-22-3-II-PTE-1414 O New O National O Excellence O Program O of O the O Ministry O for O Innovation O and O Technology O to O G.S O Project O no. O TKP2021-EGA-16 B-AWARD has O been O implemented O with O the O support O provided O from O the O National B-ORG Research I-ORG Development I-ORG and I-ORG Innovation I-ORG Fund I-ORG of I-ORG Hungary O financed O under O the O TKP2021-EGA O funding O scheme O The O research O was O performed O in O collaboration O with O the O Histology O and O Light O Microscopy O Core O Facility O at O the O Szentágothai B-ORG Research I-ORG Centre I-ORG of I-ORG the I-ORG University I-ORG of I-ORG Pécs I-ORG with O support O from O GINOP-2.3.2-15-2016-00036 B-AWARD While O rearing O developmental O stages O ofAn O entalisduring O his O stay O at O the O SBR O in O Roscoff O France O in O 2012 O T.W O was O supported O by O an O ASSEMBLE B-ORG Association O of O European O Marine O Biological O Laboratories O grant O grant O agreement I-AWARD no. I-AWARD 835 I-AWARD SBR-1 O T.W O was O also O supported O by O an O Erwin O Schrödinger O grant O Austrian O Science I-ORG Fund O grant O no. O J4198-B29 B-AWARD A.L.O O acknowledges O the O financial O support O of O the O Brazilian O program O ‘Science O without I-ORG Borders O Ciência O sem O Fronteiras O Project O Number O 6090/13-3 B-AWARD A.W O was O supported O by O grants O from O the O FWF O Austrian O Science O Fund O grant O nos O P24276-B22 B-AWARD and O P29455 B-AWARD This O research O is O financially O supported O in O part O by O the O Young B-ORG Research I-ORG Scholar I-ORG grant O no. O MRG5480205 B-AWARD from O The O Thailand O Research O Fund O the O grant O from O National B-ORG Research I-ORG Council I-ORG of I-ORG Thailand I-ORG B.E O 2561-2562 O to O Patcharee O Isarankura-Na-Ayudhya O and O the O annual O governmental O grant O of O Mahidol B-ORG University I-ORG B.E O 2557-2559 O to O Chartchalerm O Isarankura-Na-Ayudhya O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants-in-aid O from O the O Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG Project I-ORG of I-ORG Shanghai I-ORG 124119a9700 O the O Shanghai B-ORG Shen-Kang I-ORG Hospital I-ORG Management I-ORG Center I-ORG Project I-ORG of I-ORG Shanghai I-ORG SHDC12015101 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81500780 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O numbers O 22271027 B-AWARD 22171029 B-AWARD 21901024 B-AWARD and O 21871252 B-AWARD the O Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Program O grant O number O 2021YFS0315 B-AWARD and O the O Talent B-ORG Program I-ORG of I-ORG Chengdu I-ORG University O grant O numbers O 2081919035 B-AWARD and O 2081921038 B-AWARD This O research O was O funded O by O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shanxi I-ORG Province O grant O number O 202102130501011 O Major O Scientific I-ORG and I-ORG Technological I-ORG Special I-ORG Projects I-ORG of I-ORG Key I-ORG Medical I-ORG Research I-ORG Projects I-ORG of I-ORG Shanxi I-ORG Province O grant O number O 2021XM05 O the O Fund B-ORG for I-ORG the I-ORG Shanxi I-ORG “1331 I-ORG Project” I-ORG Key I-ORG Subject I-ORG Construction O grant O number O 1331KSC O and O China O Postdoctoral I-ORG Science I-ORG Foundation O grant O number O 2022M710722 O This O work O was O financially O supported O by O the O Special B-ORG Project I-ORG for I-ORG Basic I-ORG Research I-ORG of I-ORG the I-ORG Yunnan I-ORG Province I-ORG 202201AT070185 O the O Youth B-ORG Innovation I-ORG Promotion I-ORG Association I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG 2020387 O and O the O Honghe B-ORG Agroforestry I-ORG Ecological I-ORG Research I-ORG Station I-ORG of I-ORG Yunnan I-ORG Province I-ORG 202205AM070007 O This O work O was O funded O by O the B-ORG medical I-ORG education I-ORG research I-ORG project I-ORG from I-ORG Medical I-ORG education I-ORG branch I-ORG of I-ORG the I-ORG Chinese I-ORG medical I-ORG association I-ORG and I-ORG medical I-ORG education I-ORG professional I-ORG committee I-ORG of I-ORG the I-ORG Chinese I-ORG association I-ORG of I-ORG higher I-ORG education I-ORG 2018B-N02084 O the B-ORG educational I-ORG science I-ORG planning I-ORG project I-ORG in I-ORG Hubei I-ORG province I-ORG 2019GB019 O and O the O Provincial B-ORG Teaching I-ORG Research I-ORG Project I-ORG in I-ORG Hubei I-ORG 2014230 O J.M.F O work O was O supported O in O part O by O the O U.S B-ORG Department I-ORG of I-ORG Energy O Office O of O Basic O Energy O Sciences O Division O of O Chemical O Sciences O Geosciences O and O Biosciences O Physical O Biosciences O Program O DOE O DE-FG02-05ER15650 B-AWARD to O advance O understanding O of O bioenergy O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG NIH O R01 B-AWARD GM57498 O to O examine O archaeal O systems O important O to O human O health O and O the O National B-ORG Science I-ORG Foundation I-ORG MCB-1642283 O for O global O analysis O of O halophile O biology O This O work O was O supported O by O the O Projects B-ORG of I-ORG International I-ORG Cooperation I-ORG and I-ORG Exchanges I-ORG NSFC I-ORG 81420108021 O National B-ORG Key I-ORG Technology I-ORG Support I-ORG Program I-ORG 2015BAI08B02 O Excellent B-ORG Young I-ORG Scholars I-ORG NSFC I-ORG 81622033 O and O the O project O of O invigorating O Health O Care O through O Science O Technology O and O Education O This O study O was O supported O by O grants O from O the O National B-ORG Health I-ORG Research I-ORG Institute I-ORG NHRI I-ORG Taiwan I-ORG NHRI-106A1-MRCO-0517178 O and O MR-106-PP-01 B-AWARD the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Council I-ORG MOST O 111-2625-M-006-016 O and O the O Research B-ORG Centre I-ORG of I-ORG National I-ORG Cheng I-ORG Kung I-ORG University I-ORG Hospital I-ORG NCKUH-10506016 O NCKUH-11203011 B-AWARD This O research O was O supported O by O the O National B-ORG Science I-ORG Fund I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG grant O number O 81625025 B-AWARD the O Funds O for O International O Cooperation O and O Exchange O of O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81820108034 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG China I-ORG grant O number O 2018YFC1315200 B-AWARD the O State O Key O Program O of O National O Natural O Science O of O China O grant O number O 81430100 B-AWARD the O Beijing O Municipal O Science O O Technology O Commission O grant O number O Z161100000216135 O the O National O Natural O Science O Foundation O of O China O grant O number O 31700997 B-AWARD and O 31500925 B-AWARD and O the O Fundamental O Research O Funds O for O the O Central O Universities O grant O number O 2017XTCX04 B-AWARD This O review O was O supported O by O the O Cooperative O Research O Program O for O Agriculture O Science O and O Technology O Development O No. O PJ01103103 B-AWARD of O Rural B-ORG Development I-ORG Administration I-ORG in O Republic O of O Korea O the O Environmental O Health O Action O Program O No. O 2016001350004 B-AWARD funded O by O the O Ministry B-ORG of I-ORG Environment I-ORG MOE O in O Republic O of O Korea O and O the O National B-ORG Research I-ORG Foundation I-ORG of O the O Ministry O of O Education O Republic O of O Korea O NRF-2015R1C1A1A02037470 O This O research O was O supported O by O grants O from O the O Project O of O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31570328 B-AWARD 31200243 B-AWARD the O National B-ORG High-Tech I-ORG R I-ORG I-ORG D I-ORG Program I-ORG 863 O Program O for O the O 12th O Five-Year O Plan O 2011AA100503 O the B-ORG basic I-ORG research I-ORG special I-ORG fund I-ORG operations I-ORG No. O BSRF201201 B-AWARD and O National B-ORG ‘Twelfth I-ORG Five-Year’ I-ORG Plan I-ORG for I-ORG Science I-ORG I-ORG Technology I-ORG Support O 2011BAD09B01 O This O research O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2019YFC1805300 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O U1612442 B-AWARD and O High B-ORG Level I-ORG Talent I-ORG Training I-ORG Program I-ORG in I-ORG Guizhou I-ORG 20165664 O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grants#81271994 O 81301550 B-AWARD 81371971 B-AWARD 81501870 B-AWARD Jiangsu B-ORG Provincial I-ORG Six I-ORG Talent I-ORG Foundation I-ORG 2015-WSN-108 O and O 2015-WSN-110 B-AWARD Jiangsu B-ORG Province I-ORG Ordinary I-ORG University I-ORG Graduate I-ORG Student I-ORG Practice I-ORG Innovation I-ORG Engineering I-ORG SJLX15_0678 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Taiwan I-ORG NSC102-2314-B-255-003-MY2 O NSC102-2628-B-255-001-MY3 I-AWARD NSC101-2320-B-255-002 I-AWARD NSC-100-2314-B-002-094 I-AWARD NSC-101-2320 I-AWARD B-255-002 I-AWARD MOST104-2314-B-255-010-MY3 I-AWARD MOST106-2314-B-002-034-MY2 I-AWARD and I-AWARD MOST106 I-AWARD 2314-B-002-033-MY2 O he O Chang B-ORG Gung I-ORG Memorial I-ORG Hospital I-ORG CMRPF1H0061 O CMRPF1F0071 I-AWARD CMRPF1G0101 I-AWARD CMRPF1G0102 I-AWARD CMRPF3E0021 I-AWARD CMRPF3E0022 I-AWARD CMRPF3E0023 I-AWARD NMRPF3C0091 I-AWARD NMRPF3C0061 I-AWARD CMRPG1B0031 I-AWARD CMRPF170053 I-AWARD NMRPF370033 I-AWARD CMRPF3E0021 I-AWARD NMRPF3B0071 I-AWARD NMRPF3E0041 I-AWARD NMRPF3E0042 I-AWARD NMRPF3E0043 I-AWARD NMRPF3C0093 I-AWARD NMRPF3H0071 I-AWARD NMRPF3H0061 O CMRPF1C0011 O 1C0012 O and O the O National B-ORG Taiwan I-ORG University I-ORG Hospital I-ORG NTUH O 101-001937 I-AWARD NTUH102-002259 I-AWARD NTUH101-S1862 I-AWARD I-AWARD NTUH102-S2180 I-AWARD NTUH103-S2368 I-AWARD NTUH104-S2658 I-AWARD NTUH106-S3467 I-AWARD NTUH106-UN-001 O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31772760 O the O Award O for O “Liaoning B-ORG Distinguished I-ORG Professor” I-ORG the I-ORG Liaoning I-ORG Province I-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG of I-ORG China I-ORG 20170540377 O and I-AWARD 20180550289 O and O the O National B-ORG College I-ORG Students’ I-ORG innovation I-ORG and I-ORG entrepreneurship I-ORG training I-ORG program I-ORG of I-ORG Jinzhou I-ORG Medical I-ORG University I-ORG 201710160000189 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG City I-ORG No. O 201704030075 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2016A030310349 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51673071 O and O Science O and O Technology O Planning O Project O of O Guangdong O Province O No. O 2016B090918040 O This O work O was O supported O by O grants O from O the O National O Institutes O of O Health O NIH O the O National B-ORG Institute I-ORG of I-ORG Neurological I-ORG Disorders I-ORG and I-ORG Stroke I-ORG NIH-NINDS-R01NS065201 O and O NIH-NINDS-R15NS116478 B-AWARD to O S.N.S O the O National B-ORG Institute I-ORG on I-ORG Minority I-ORG Health I-ORG and I-ORG Health I-ORG Disparities I-ORG NIH-NIMHD-G12MD007583 O to O UCC O and O the O National B-ORG Institute I-ORG of I-ORG General I-ORG Medicine I-ORG NIH-NIGMS-U54GM133807 O to O Alliance O TRRCL-UCC O Support O for O core O facilities O This O study O was O supported O by O Chinese B-ORG PLA I-ORG General I-ORG Hospital I-ORG Medical I-ORG Large I-ORG Data I-ORG Project I-ORG No. O 2016MBD-002 B-AWARD Chinese B-ORG PLA I-ORG General I-ORG Hospital I-ORG Translational I-ORG Medicine I-ORG Project I-ORG No. O 2016-TM-013 B-AWARD Major B-ORG International I-ORG Science I-ORG and I-ORG Technology I-ORG Cooperation I-ORG Projects I-ORG No. O 2013DFA31170 B-AWARD and O National O Key O Technologies O R&D O Program O for O New O Drug O of O China O 2018ZX09J18109-004 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O Scientific B-ORG and I-ORG Technological I-ORG Cooperation I-ORG Project I-ORG of I-ORG China I-ORG and I-ORG Slovakia I-ORG 7-12 O APVV-SK-CN-2015-0010 B-AWARD Advanced B-ORG Talents I-ORG of I-ORG Hebei I-ORG Normal I-ORG University I-ORG L2018B15 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hebei I-ORG province I-ORG C2018205211 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31802008 O Project B-ORG of I-ORG the I-ORG Slovak I-ORG Scientific I-ORG Grant I-ORG Agency I-ORG VEGA I-ORG no. O 2/0126/16 B-AWARD Projects O PICT B-AWARD 2019-03380 O PICT B-AWARD 2019-2827 O and O PICT B-AWARD 2018-3285 I-AWARD ANPCyT O Argentina O PGI B-AWARD 24/ZQ18 I-AWARD UNS O and I-ORG CONICET B-ORG Argentina O and O PIP B-AWARD 2022-00493CO I-AWARD CONICET O Argentina O and O Drs O Florencia O Ortega O and O Yuliana O Monroy O Post-Doctoral O Fellowship O CONICET O CONICET O Argentina O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 41701543 B-AWARD and O 41877508 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O No. O 2018NTST20 B-AWARD and O 2017XTCX02 B-AWARD the O 111 B-ORG Project I-ORG B18006 O the O International O Partnership O Program O of O Chinese O Academy O of O Sciences O Grant O No. O 132744KYSB20170002 O and O Institution O Centre O of O Excellence O HiCOE O Phase O II O Fund O Ministry O of O Higher O Education O IOES-2014D O Malaysia O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 62111530238 O 62003046 B-AWARD the O Strategic B-ORG Research I-ORG Grant I-ORG of I-ORG City I-ORG University I-ORG of I-ORG Hong I-ORG Kong I-ORG Project O No. O CityU O 7004600 B-AWARD and O grants O from O Serbian B-ORG Ministry I-ORG of I-ORG Science I-ORG Technological I-ORG Development I-ORG and I-ORG Innovations I-ORG Agreement O No. O 451-03-68/2022-14/200122 B-AWARD and O 451-03-47/2023-01/200123 B-AWARD by O grant O from O Science B-ORG Fund I-ORG of I-ORG the I-ORG Republic I-ORG of I-ORG Serbia I-ORG Agreement O No. O CTPCF-6379382 B-AWARD Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG 2021A1515011997 O Special B-ORG project I-ORG in I-ORG key I-ORG field I-ORG of I-ORG Guangdong I-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG 2021ZDZX1050 O The B-ORG Innovation I-ORG Team I-ORG Project I-ORG of I-ORG Guangdong I-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG 2021KCXTD014 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 31670724 O 31570722 B-AWARD National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC1305800 O 2016YFC1305805 B-AWARD National O 1000 O Young O Talents O Program O of O China O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG HUST O 2018KFYYXJJ033 B-AWARD startup O grant O of O Huazhong B-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 3004012104 O Funding O for O open O access O charge O NSFC O This O research O was O funded O by O the O Hebei B-ORG Provincial I-ORG Innovation I-ORG Capacity I-ORG Improvement I-ORG Plan I-ORG Project I-ORG 20567632H O Hebei B-ORG Natural I-ORG Science I-ORG Foundation I-ORG C2019405105 O Project B-ORG of I-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Training I-ORG Plan I-ORG for I-ORG College I-ORG Students I-ORG of I-ORG Hebei I-ORG Province I-ORG S202110092001 O This O work O was O supported O by O grants O to O the O following O authors O UK B-ORG Natural I-ORG Environment I-ORG Research I-ORG Council I-ORG NERC O grant O no. O NE/H00548X/1 B-AWARD to O A.R.B O Chemical O Oceanography O Program O of O the O National B-ORG Science I-ORG Foundation I-ORG grant O no. O OCE-1034746 B-AWARD to O D.K O and O W.M.L O NERC O grant O nos O NE/I021616/1 B-AWARD and I-AWARD NE/K000845/1 O and O the O Royal B-ORG Society-NSFC I-ORG to O Z.S O the O BOA O project O ANR-05-BLANC O 0153 O the O BIOCAP B-ORG project O ANR-13-BS06-0004 O the O GIS-Europôle O Mer O research O axis O 2 O ‘Global O Change-Ocean-Marine O Ecosystems O Interactions’ O and O a O grant O from O the O European O CoOperation O in O Science O and O Technology O COST O Action O 735 O ‘Tools O for O assessing O global O air-sea O fluxes O of O climate O and O air O pollution O relevant O gases’ O to O M.C O E.B O and O G.S O German B-ORG BMBF I-ORG SOPRAN I-ORG project O grant O no. O FKZ03F0662A B-AWARD to O N.R O This O research O was O funded O by O the O Youth B-ORG Innovation I-ORG Foundation I-ORG of I-ORG Xiamen I-ORG City I-ORG 3502Z20206085 O Opening B-ORG Project I-ORG of I-ORG PCOSS I-ORG Xiamen I-ORG University I-ORG 201907 O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDB20000000 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21805280 O 22275185 B-AWARD 21962006 B-AWARD U22A20396 B-AWARD 22288102 B-AWARD and O 32101217 B-AWARD Major B-ORG Research I-ORG Project I-ORG of I-ORG Xiamen I-ORG 3502Z20191015 O Fujian B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Laboratory I-ORG for I-ORG Optoelectronic I-ORG Information I-ORG of I-ORG China I-ORG 2021ZR132 O and O 2021ZZ115 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG 2006L2005 O Key B-ORG Program I-ORG of I-ORG Frontier I-ORG Science I-ORG CAS I-ORG QYZDJ-SSW-SLH033 O and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 20720220009 O This O work O was O financially O supported O by O the O PON B-AWARD 03 I-AWARD PE_00110_1/ptd1_000410 I-AWARD Titolo O Sviluppo B-ORG di I-ORG nanotecnologie I-ORG Orientate I-ORG alla I-ORG Rigenerazione I-ORG e I-ORG Ricostruzione I-ORG tissutale I-ORG Implantologia I-ORG e I-ORG Sensoristica I-ORG in I-ORG Odontoiatria/oculistica I-ORG SORRISO O POR B-ORG Campania I-ORG FESR B-AWARD 2014_2020 I-AWARD “Tecnologie O abilitanti O per O la O sintesi O eco-sostenibile O di O nuovi O materiali O per O la O restaurativa O dentale”–ABILTECH O EU B-ORG funding I-ORG within I-ORG the I-ORG Horizon I-ORG 2020 I-ORG Program O under O the O MSCA-RISE O 2016 O Project O “VAHVISTUS” O Grant O 734759 B-AWARD PRIN B-AWARD 201288JKYY I-AWARD Titolo O Nanotecnologie B-ORG per I-ORG variare I-ORG i I-ORG programmi I-ORG di I-ORG sviluppo I-ORG osseo I-ORG nella I-ORG parete I-ORG vasale I-ORG per I-ORG la I-ORG prevenzione I-ORG e I-ORG trattamento I-ORG delle I-ORG patologie I-ORG associate I-ORG alla I-ORG calcificazione I-ORG ectopica I-ORG arteriosa I-ORG This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81600609 O Shanghai B-ORG JiaoTong I-ORG University I-ORG School I-ORG of I-ORG Medicine I-ORG 2014 O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG 16411971200 O 16410723200 B-AWARD the B-ORG Fourth I-ORG Round I-ORG of I-ORG Three-Year I-ORG Public I-ORG Health I-ORG Action I-ORG Plan I-ORG of I-ORG Shanghai I-ORG by I-ORG the I-ORG Shanghai I-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG 20164Y0079 O and O Municipal B-ORG Human I-ORG Resources I-ORG Development I-ORG Program I-ORG for I-ORG Outstanding I-ORG Young I-ORG Talents I-ORG in I-ORG Medical I-ORG and I-ORG Health I-ORG Sciences I-ORG in I-ORG Shanghai I-ORG 2017YQ053 O This O work O was O supported O by O the O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG Senior O Investigator O Award O NF-SI_0513-10025 O and O the O Medical B-ORG Research I-ORG Council I-ORG North O West O Hub O for O Trials O Methodology O Research O grant O MR/K025635/1 O Karen O Matvienko-Sikar O is O funded O by O a O Health B-ORG Research I-ORG Board I-ORG Interdisciplinary O Capacity O Enhancement O Award O 2015-1026 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 3132019203 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2017M611209 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province I-ORG 20170540083 O This O research O was O supported O by O Hong B-ORG Kong I-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Fund I-ORG 13141541 O the O University B-ORG Grants I-ORG Committee I-ORG UGC I-ORG of I-ORG Hong I-ORG Kong I-ORG RPC10HSS01 O and O the O Australian B-ORG Research I-ORG Council I-ORG Centre I-ORG of I-ORG Excellence I-ORG in I-ORG Population I-ORG Ageing I-ORG Research I-ORG CE110001029 O This O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG CN) O 31301033 O website:http://www.nsfc.gov.cn O PI: O Tao O Luo O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG the I-ORG People's I-ORG Republic I-ORG of I-ORG China I-ORG 2014DFA30340 O website:http://www.most.gov.cn/index.htm O PI: O Qian O Gao O and O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG 2013ZX10004903-006 O website:http://www.most.gov.cn/index.htm O PI: O Qian O Gao O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O study O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81703274 B-AWARD the O China B-ORG Mega-Project I-ORG for I-ORG Infectious I-ORG Diseases I-ORG Grant I-ORG 2017ZX10103004 O the O Youth B-ORG Innovation I-ORG Funding I-ORG 2014QN09 O and O the O Peking B-ORG University I-ORG Medicine I-ORG Seed I-ORG Fund I-ORG for I-ORG Interdisciplinary I-ORG Research I-ORG BMU2018MX009 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31971864 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG of O China O grant O number O 2019CFC851 B-AWARD and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities O grant O numbers O 2662016QD040 B-AWARD and O 2662018YJ025 B-AWARD This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32070171 O and O partially O supported O by O open O project O funding O of O the O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Biocatalysis I-ORG and I-ORG Enzyme I-ORG Engineering I-ORG SKLBEE2022026 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG 2020CFB831 O and O Xiangyang B-ORG City I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG Project I-ORG 2021YL46 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81402928 B-AWARD 81773720 B-AWARD to O Dr. O Ning O Hou O Guangzhou B-ORG Education I-ORG Bureau I-ORG Project I-ORG No. O 1201610064 B-AWARD to O Dr. O Ning O Hou O and O Guangzhou B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG No. O 201804010490 B-AWARD to O Dr. O Ning O Hou O The O funders O play O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O grants O from O the O University B-ORG of I-ORG Buenos I-ORG Aires I-ORG UBACyT O 20020170100199BA B-AWARD the O National B-ORG Council I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG CONICET O PIP O 11220170100539CO B-AWARD and O PIP O 11220210100183CO B-AWARD and O National B-ORG Agency I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Promotion I-ORG ANPCyT O PICT-2020-SERIEA-03542 B-AWARD This O work O was O supported O by O grants O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31671656 O the O Fundamental O Research O Funds O for O the O Central O Universities O 2662018YJ025 O the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG No. O 2014AA10A600 O and O the O National B-ORG Research I-ORG Foundation I-ORG for I-ORG the I-ORG Doctoral I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG of I-ORG China I-ORG No. O 20120146110013 O The O funding O bodies O had O no O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O received O financial O support O from O Socail B-ORG Development I-ORG Research I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG http://xmsb.jschina.com.cn/indexAction!to_index.action O Project O No O BE2015646 B-AWARD to O QX, O Maternal B-ORG and I-ORG Child I-ORG Healthcare I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Health I-ORG Department I-ORG http://www.jswst.gov.cn/jsswshjhsywyh/index.html O Project O No.:F201407 O to O YS, O Youth B-ORG Fund I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Health I-ORG Department I-ORG http://www.jswst.gov.cn/jsswshjhsywyh/index.html O Project O No.:Q201305 O to O QX, O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Nanjing I-ORG City I-ORG http://www.njkj.gov.cn O Project O No.:201201054 O to O QX, O and O Student O Research O Training O Program O http://srtp.seu.edu.cn O 1510286111 O to O XZ. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O is O funded O by O research O grants O from O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Taiwan I-ORG MOST O 107-2628-E-007-001-MY3 I-AWARD to O C.-M.C O MOST B-AWARD 108-2314-B-006-080-MY3 I-AWARD to O S.-C.P O National B-ORG Cheng I-ORG Kung I-ORG University I-ORG Hospital I-ORG NCKUH-10705018 O the O International O Center O for O Wound O Repair O and O Regeneration O at O National O Cheng O Kung O University O from O The O Featured O Areas O Research O Center O Program O within O the O framework O of O the O Higher O Education O Sprout O Project O by O the O Ministry B-ORG of I-ORG Education I-ORG MOE O in O Taiwan O and O by O the O grant O of O the O Ministry O of O Science O and O Technology O MOST O 107-3017-F-006-002 O and O the O Frontier O Research O Center O on O Fundamental O and O Applied O Sciences O of O Matters O from O The O Featured O Areas O Research O Center O Program O within O the O framework O of O the O Higher O Education O Sprout O Project O by O the O Ministry O of O Education O MOE O 107QR001I5 O in O Taiwan O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No: O 81672272 B-AWARD Shanghai B-ORG Scientific I-ORG Research I-ORG Projects I-ORG Grant O No: O 14140902800 B-AWARD Shanghai B-ORG Municipal I-ORG Health I-ORG Bureau I-ORG Key I-ORG Subject I-ORG Grant O No: O 201540365 B-AWARD International B-ORG S&T I-ORG Cooperation I-ORG Program I-ORG of I-ORG China I-ORG Grant O No: O 2012DFG31320 B-AWARD National O Natural O Science O Foundation O of O China O Grant O No: O 81401880 B-AWARD Funds B-ORG from I-ORG Shanghai I-ORG Chest I-ORG Hospital I-ORG Grant O No: O 2014YZDC10600 B-AWARD Chinese B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2013CB945604 O and O National O Natural O Science O Foundation O of O China O 31270032 O This O study O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFC1001303 O to O H.-F.H O the O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG LQ18H040005 O to O J.-X.P O the O Natural O Science O Foundation O of O China O 31471405 O to O H.-F.H O 81401167 B-AWARD to O F.-F.W O 81501276 B-AWARD to O Y.-Q.X O Zhejiang B-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG Foundation I-ORG 2017ZQ020 O to O J.-X.P O Zhejiang B-ORG Project I-ORG of I-ORG Medical I-ORG and I-ORG Health I-ORG Research I-ORG 2017KY462 O to O J.-X.P O and O Wenzhou B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG CN) O Y20160037 O to O J.-X.P O This O study O was O supported O by O grants O from O the O 5010 B-ORG Project I-ORG Foundation I-ORG of I-ORG Sun I-ORG Yat-sen I-ORG University I-ORG No. O 2017001 B-AWARD National B-ORG major I-ORG and I-ORG development I-ORG projects I-ORG No. O 2018YFC1314100 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Foundation I-ORG of I-ORG Guangzhou I-ORG City I-ORG No. O 201803010101 B-AWARD This O work O was O financially O supported O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 31672106 B-AWARD the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD1000105 O Zhongyuan B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Leaders I-ORG 194200510007 O and O Innovative O Research O Team O in O Henan O University O of O Science O and O Technology O 2015TTD003 O China O This O work O was O supported O by O the O National B-ORG 973 I-ORG Project I-ORG of I-ORG China I-ORG No. O 2013CB733600 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 21676189 B-AWARD the O Key B-ORG Technologies I-ORG R&D I-ORG Program I-ORG of I-ORG Tianjin I-ORG No. O 16YFZCSY00780 B-AWARD and O the O Key B-ORG Program I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 21236005 B-AWARD This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 61573091 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O N182608003 I-AWARD No. I-AWARD N172608005 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province I-ORG 20180520006 O This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG grant O number O 2016YFD0500203 B-AWARD the B-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG of I-ORG China I-ORG grant O number O 2017ZX10304402-003-006 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 32270562 B-AWARD Great B-ORG Scientific I-ORG and I-ORG Technological I-ORG Innovation I-ORG Projects I-ORG in I-ORG Shandong I-ORG Province I-ORG grant O number O 2022CXGC010606 B-AWARD and O Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG grant O number O ZR2022MC007 B-AWARD ZR2021MC119 B-AWARD We O thank O Dr. O Zhendong O Guo O for O providing O the O A/Hebei/F076/2018 O H1N1 O strains O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81302531 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG of I-ORG China I-ORG BK20181492 O the O Talents B-ORG Planning I-ORG of I-ORG Six I-ORG Summit I-ORG Fields I-ORG of I-ORG Jiangsu I-ORG Province I-ORG 2013-WSN-037 O Postgraduate B-ORG Research I-ORG I-ORG Practice I-ORG Innovation I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG KYCX17_1287 O Postgraduate O Research O O Practice O Innovation O Program O of O Jiangsu O Province O SJCX18_0435 O the B-ORG National I-ORG Key I-ORG Clinical I-ORG Department I-ORG of I-ORG Laboratory I-ORG Medicine I-ORG of I-ORG China I-ORG in I-ORG Nanjing I-ORG Key I-ORG laboratory I-ORG for I-ORG Laboratory I-ORG Medicine I-ORG of I-ORG Jiangsu I-ORG Province I-ORG ZDXKB2016005 O and O by O the O Priority O Academic O Program O Development O of O Jiangsu O Higher O Education O Institutions O This O study O was O supported O by O Beijing B-ORG Science I-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Beijing I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG Z131100005613048 O China B-ORG Special I-ORG Grant I-ORG for I-ORG the I-ORG Prevention I-ORG and I-ORG Control I-ORG of I-ORG Infectious I-ORG Diseases I-ORG 2013ZX10004218 O Scientific B-ORG Research I-ORG Cultivation I-ORG Project I-ORG 2015-yj-cd-002 O Beijing B-ORG Health I-ORG System I-ORG High I-ORG Level I-ORG Health I-ORG Technology I-ORG Talent I-ORG Cultivation I-ORG Plan I-ORG 2013-3-098 O Beijing B-ORG Talents I-ORG Fund I-ORG 2014000021223ZK36 O and O Expanding B-ORG the I-ORG use I-ORG of I-ORG seasonal I-ORG influenza I-ORG vaccines I-ORG in I-ORG public I-ORG health I-ORG programs I-ORG in I-ORG China I-ORG 1U51IP000819-01 O The O study O was O financially O supported O by O the O JILIN B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Plan I-ORG 201505200125JH O and O JILIN B-ORG province I-ORG project I-ORG for I-ORG transformation I-ORG of I-ORG scientific I-ORG and I-ORG technological I-ORG achievements I-ORG 20140307008NY O Technology B-ORG Innovation I-ORG Program I-ORG from I-ORG Chinese I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG 20140204066NY O O This O work O was O supported O by O a O grant O from O the O Research B-ORG Fund I-ORG for I-ORG the I-ORG Chengdu I-ORG Research I-ORG of I-ORG Giant I-ORG Panda I-ORG Breeding I-ORG Project O No. O CPF2014-17 B-AWARD the O Livestock B-ORG Breeding I-ORG Project I-ORG of I-ORG Sichuan I-ORG Province I-ORG Project O No. O 2016NYZ0046 B-AWARD and O the O Special B-ORG Financial I-ORG Operation I-ORG of I-ORG Sichuan I-ORG Province I-ORG Project O No. O SASA2014CZYX005 B-AWARD The O funder O had O no O role O in O study O design O data O collection O and O analysis O preparation O or O publication O of O the O manuscript O The O authors O would O like O to O thank O the O Deanship B-ORG of I-ORG Scientific I-ORG Research I-ORG at I-ORG Umm I-ORG Al-Qura I-ORG University I-ORG for O supporting O this O work O by O Grant O Code O 22UQU4400074DSR05 B-AWARD This O study O is O supported O via O funding O from O Prince B-ORG Satam I-ORG bin I-ORG Abdulaziz I-ORG University I-ORG project O number O PSAU/2023/R/1444 O Princess B-ORG Nourah I-ORG bint I-ORG Abdulrahman I-ORG University I-ORG Researchers I-ORG Supporting O Project O number O PNURSP2023R163 O Princess O Nourah O bint O Abdulrahman O University O Riyadh O Saudi O Arabia O This O work O was O supported O by O the O Universidad B-ORG Nacional I-ORG Autónoma I-ORG de I-ORG México I-ORG UNAM-PAPIIT O grant O IA200814 B-AWARD to O AEE O and O SEMARNAT-CONACyT B-ORG grant O 23459 B-AWARD to O VS O SP O received O financial O support O from O a O CONACyT B-ORG research I-ORG visiting I-ORG fellowship I-ORG 186372 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O Youth B-ORG Science I-ORG and I-ORG Technology I-ORG Fund I-ORG Planning I-ORG Project I-ORG of I-ORG Gansu I-ORG Province I-ORG 1606RJYA256 O the O Central B-ORG public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG 1610312016018 O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG of I-ORG China I-ORG 2013BAD12B05 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC I-ORG 31702266 O and O the O Central B-ORG Public-interest I-ORG Scientific I-ORG Institution I-ORG Basal I-ORG Research I-ORG Fund I-ORG 1610312016016 O The O project/research O is O co-financed O by O the O European B-ORG Regional I-ORG Development I-ORG Fund I-ORG ERDF O under O the O Operational O Program O “Epirus O 2014–2020,” O NSRF B-AWARD 2014–2020 I-AWARD Grant O Number O 5033143 B-AWARD acronym O EPIRUSCOSMECEUTICALS O to O AGT O The O research O work O was O supported O by O the O Hellenic B-ORG Foundation I-ORG for I-ORG Research I-ORG and I-ORG Innovation I-ORG H.F.R.I O under O the O “First O Call O for O H.F.R.I O Research O Projects O to O Support O Faculty O Members O and O Researchers O and O the O Procurement O of O High-Cost O Research O Equipment O Grant” O Project O Number O 991 B-AWARD acronym O PROTECT O to O AGT O We O acknowledge O the O support O of O this O work O by O the O project O “Infrastructure O of O Microbiome O Applications O in O Food O Systems-FOODBIOMES” O MIS O 5047291 O which O is O implemented O under O the O Action O “Regional O Excellence O in O R&D O Infrastructures,” O funded O by O the O Operational B-ORG Program I-ORG “Competitiveness I-ORG Entrepreneurship I-ORG and I-ORG Innovation” I-ORG NSRF O 2014–2020 O and O co-financed O by O Greece O and O the O European O Union O European O Regional O Development O Fund O This O work O was O supported O by O grants O from O the O State B-ORG Key I-ORG Basic I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG 2010CB126003 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 90608016 O the O National B-ORG Transgenic I-ORG Animals I-ORG and I-ORG Plants I-ORG Research I-ORG Project I-ORG 2011ZX08009-003 O and O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Cotton I-ORG Biology I-ORG Open I-ORG Fund I-ORG CB2015A01 O The O funding O bodies O do O not O have O a O role O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O J.T O Imperial B-ORG Health I-ORG Charity O 151612 B-AWARD CMM O National B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG NIHR O Cambridge O Biomedical O Research O Centre O 146281 B-AWARD W.G O and O S.V O Agency B-ORG for I-ORG Innovation I-ORG by I-ORG Science I-ORG and I-ORG Technology I-ORG IWT O in O Brussels O Belgium O as O part O of O the O Limburg O Clinical O Research O Program O by O the O Limburg O Clinical O Research O Center O LCRC O a O collaborative O initiative O between O Hasselt O University O Ziekenhuis O Oost O Limburg O Genk O and O Jessa O Ziekenhuis O Hasselt O in O the O province O of O Limburg O Belgium O 131581 B-AWARD C.C.L O Action B-ORG Medical I-ORG Research O 2450 B-AWARD C.C.L O was O supported O by O the O National O Institute O for O Health O Research O Comprehensive O Biomedical O Research O Centre O at O Imperial O College O Healthcare O NHS O Trust O and O Imperial O College O London O The O views O expressed O are O those O of O the O author(s O and O not O necessarily O those O of O Imperial O College O the O NHS O the O NIHR O or O the O Department O of O Health O Surveys O providing O data O for O this O study O were O principally O funded O by O the O Global O Trachoma O Mapping O Project O GTMP O grant O from O the O United O Kingdom’s O Department B-ORG for I-ORG International I-ORG Development I-ORG ARIES O 203145 O to O Sightsavers O which O led O a O consortium O of O non-governmental O organisations O and O academic O institutions O to O support O ministries O of O health O to O complete O baseline O trachoma O mapping O worldwide O The O GTMP O was O also O funded O by O the O United B-ORG States I-ORG Agency I-ORG for I-ORG International I-ORG Development I-ORG USAID O through O the O ENVISION O project O implemented O by O RTI O International O under O cooperative O agreement O number O AID-OAA-A-11-00048 O and O the O END O in O Asia O project O implemented O by O FHI360 O under O cooperative O agreement O number O OAA-A-10-00051 O A O committee O established O in O March O 2012 O to O examine O issues O surrounding O completion O of O global O trachoma O mapping O was O initially O funded O by O a O grant O from O Pfizer O to O the O International O Trachoma O Initiative O AWS O was O a O Wellcome B-ORG Trust I-ORG Intermediate O Clinical O Fellow O 098521 O at O the O London O School O of O Hygiene O O Tropical O Medicine O and O is O now O a O staff O member O of O the O World O Health O Organization O None O of O the O funders O had O any O role O in O project O design O in O project O implementation O or O analysis O or O interpretation O of O data O in O the O decisions O on O where O how O or O when O to O publish O in O the O peer O reviewed O press O or O in O the O preparation O of O this O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.81873748 O 81870364 B-AWARD 81470264 B-AWARD and O Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O ZR2017MH010 B-AWARD ZR2015PH036 B-AWARD ZR2014HM027 B-AWARD China B-ORG Scholarship I-ORG Council I-ORG No. O 201706225023 B-AWARD and O the O Key B-ORG Technologies I-ORG Research I-ORG and I-ORG Development I-ORG Programme I-ORG of O Shandong O Province O No. O 2018GSF118061 B-AWARD This O study O was O supported O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Non-profit I-ORG Research I-ORG Institution I-ORG of I-ORG CAF I-ORG CAFYBB2014QB015 O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 I-ORG Program I-ORG 2012CB114505 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31570662 O 31500533 I-AWARD and I-AWARD 61401214 O We O also O received O support O from O Key O Projects O in O the O National B-ORG Science I-ORG I-ORG Technology I-ORG Pillar I-ORG Program I-ORG during I-ORG the I-ORG Twelfth I-ORG Five-year I-ORG Plan I-ORG Period I-ORG No. O 2012BAD01B07 B-AWARD and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG 14KJB520018 O This O work O is O also O enabled O by O the O Innovative O Research O Team O Program O of O the O Educational O Department O of O China O the O Innovative O Research O Team O Program O in O Universities O of O Jiangsu O Province O Scientific O Research O Foundation O for O Advanced O Talents O and O Returned O Overseas O Scholars O of O Nanjing O Forestry O University O and O the O PAPD O Priority O Academic O Program O Development O program O at O Nanjing O Forestry O University O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O Strategic B-ORG Priority I-ORG Research I-ORG Program I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG Grant O no. O XDB15010301 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O No. O 31570466 B-AWARD and O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG Grant O no. O 2012CB416905 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O funded O by O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo I-ORG FAPESP O grant O number O 2016/20045-7 B-AWARD FAPESP O grant O numbers O 2018/14459-9 B-AWARD M.F.C.A O 2016/05570-8 B-AWARD L.R.P O 2022/01034-5 B-AWARD A.A.V.B.C O 2018/20162-9 B-AWARD A.B O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico I-ORG CNPq O grant O numbers O 440409/2016-0 B-AWARD and O 407592/2016-4 B-AWARD Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior I-ORG CAPES O grant O numbers O 116618/2016-01 B-AWARD and O 130787/2016-01 B-AWARD CAPES O grant O numbers O 88887.600175/2021-00 B-AWARD S.S.P O This O research O was O funded O by O the O Fujian B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Laboratory I-ORG for I-ORG Optoelectronic I-ORG Information I-ORG of I-ORG China I-ORG 2021ZR130 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG 2021J01513 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 22175178 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.31572612 O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG China I-ORG 2017A030303008 O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG China I-ORG No. O 201803020043 O This O research O was O funded O by O the B-ORG study I-ORG on I-ORG key I-ORG technologies I-ORG for I-ORG healthy I-ORG production I-ORG of I-ORG efficient I-ORG resources I-ORG utilization I-ORG in I-ORG protected I-ORG vegetables I-ORG 2016BZ09 O by O research B-ORG on I-ORG key I-ORG technologies I-ORG and I-ORG supporting I-ORG equipment I-ORG of I-ORG protected I-ORG vegetable I-ORG production I-ORG CX161002 O and O by O the B-ORG achievement I-ORG transformation I-ORG of I-ORG multilayer I-ORG stereo I-ORG water I-ORG culture I-ORG AA16380048 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81572726 O 81760112 B-AWARD 81402426 B-AWARD 81402509 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2018A030313641 O 2016A030313848 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2016A020212004 O 2017B020247057 B-AWARD and O the O Medical B-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG A2016312 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No, O 81601088 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jilin I-ORG Province I-ORG No, O 20160520164JH B-AWARD and O the B-ORG 7th I-ORG Youth I-ORG Foundation I-ORG of I-ORG the I-ORG First I-ORG Hospital I-ORG of I-ORG Jilin I-ORG University I-ORG No, O JDYY72016028 B-AWARD This O work O was O funded O by O the O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG Distrito I-ORG Federal I-ORG FAPDF O grant O number O 0193.001725/2017 B-AWARD and O the O Instituto B-ORG Nacional I-ORG de I-ORG Ciência I-ORG e I-ORG Tecnologia I-ORG MCTI/CNPq/CAPES/FAPDF O grant O number O 465480/2014-4 B-AWARD ECSR O TDMP O GSCA O and O FCDAF O were O supported O by O scholarships O from O CAPES O grant O number O 001 O RNGM O was O supported O by O fellowships O from O CNPq O grant O numbers O 305418/2017-3 B-AWARD and O 308165/2021-7 B-AWARD This O study O was O supported O by O the O Bolyai B-ORG János I-ORG Research I-ORG Scholarship I-ORG BO/701/20/5 O and O by O the O ÚNKP-22-5-SZTE B-AWARD New B-ORG National I-ORG Excellence I-ORG Program I-ORG of I-ORG The I-ORG Ministry I-ORG for I-ORG Innovation I-ORG and I-ORG Technology I-ORG from I-ORG the I-ORG Source I-ORG of I-ORG National I-ORG Research I-ORG Development I-ORG and I-ORG Innovation I-ORG Fund I-ORG Hungary O and O by O the O EU B-ORG through I-ORG the I-ORG Economic I-ORG Development I-ORG and I-ORG Innovation I-ORG Operational I-ORG Programme I-ORG GINOP-2.3.3-15-2016-00040 O Design O of O the O study O was O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0500800 O preparation O of O material O was O supported O by O National B-ORG Key I-ORG R I-ORG D I-ORG Program I-ORG 2016YFD0500800 O and O Sichuan B-ORG Province I-ORG Research I-ORG Programs I-ORG 2017JY0014/2017HH0026 O collection O analysis O and O interpretation O of O data O were O supported O by O China B-ORG Agricultural I-ORG Research I-ORG System I-ORG CARS-43-8 O and O authors O of O this O paper O receive O financially O supported O by O Sichuan O Province O Research O Programs O 2017JY0014/2017HH0026 O This O research O was O co-financed O by O the O REPUBLIC B-ORG OF I-ORG SLOVENIA I-ORG MINISTRY I-ORG OF I-ORG EDUCATION I-ORG SCIENCE I-ORG AND I-ORG SPORT I-ORG and I-ORG the I-ORG EUROPEAN I-ORG REGIONAL I-ORG DEVELOPMENT I-ORG FUND I-ORG through O the O EU O Cohesion O Policy O 2014–2020 O under O grant O agreement O No. O C3330-19-952045 B-AWARD Project O “Raziskovalci-2.1-ZAG-952045” O and O THE O SLOVENIAN B-ORG RESEARCH I-ORG AGENCY I-ORG through O Research O Core O Funding O No. O P2-0273 B-AWARD and O Infrastructure B-ORG programme I-ORG No. O I0-0032 B-AWARD This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81700567 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG 2022CFB122 O and O Natural B-ORG Science I-ORG Independent I-ORG Research I-ORG Project I-ORG of I-ORG Wuhan I-ORG University I-ORG 2042021kf0135 O This O work O received O funding O from O the O Microbiology B-ORG and I-ORG the I-ORG Food I-ORG Chain I-ORG division I-ORG MICA O of O the O INRA O institute O through O the O metaprogramme O MEM O O Meta-omics O and O microbial O ecosystems O two O ANR O projects O SerpinGuTarget B-ORG and O Titan B-ORG and O the O CMCU-PHC O Utique O n°19G0819 O O Campus B-ORG France I-ORG 41786NC O This O work O was O supported O by O the O SerpinGuTarget O Contract O number O ANR-14-CE16-0018 B-AWARD and O Titan O Contract O number O ANR-18-CE18-0019-03 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Council I-ORG for I-ORG Scientific I-ORG and I-ORG Technological I-ORG Development I-ORG CNPq O grant O 471653/2013-6 B-AWARD and O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG do I-ORG Rio I-ORG Grande I-ORG do I-ORG Sul I-ORG FAPERGS O grant O 16/2551-0000365-3 B-AWARD The O authors O gratefully O acknowledge O the O student O fellowships O from O Coordination O of O Superior O Level O Staff O Improvement O CAPES O to O A.C.M.B O N.S.S O M.H.M.S O and O CNPq O to O M.D O and O É.V.F.R O A.F.F O grant O 304824/2016-0 B-AWARD and O 304825/2020-4 B-AWARD M.S.O O L.F.F.R O M.R.F O and O R.N.M O are O grantees O of O CNPq O research O productivity O fellowships O The O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O 81903141 B-AWARD 81973275 B-AWARD Clinical B-ORG Pharmacy I-ORG Innovation I-ORG Research I-ORG Institute I-ORG of I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG School I-ORG of I-ORG Medicine I-ORG CXYJY2019MS002 O NSFC O 81972891 B-AWARD Basic B-ORG research I-ORG project I-ORG of I-ORG Shanghai I-ORG science I-ORG and I-ORG technology I-ORG commission(18JC1414200 O and O Shanghai B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Flanning-Construction I-ORG of I-ORG clinical I-ORG pharmacy I-ORG service I-ORG system(2016ZB0303 O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81790643 O 82121003 B-AWARD and O 82101163 B-AWARD the O Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG 2021YFS0404 O 2021YFS0369 B-AWARD and O 2021YFS0388 B-AWARD the O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG 2019-12M-5-032 O Clinical B-ORG Research I-ORG Foundation I-ORG of I-ORG Sichuan I-ORG Provincial I-ORG People’s I-ORG Hospital I-ORG 2021LY23 O German B-ORG Federal I-ORG ministry I-ORG of I-ORG Education I-ORG and I-ORG Research I-ORG BMBF O 03Z2EN11 I-AWARD to O M.S O Franco-German O PROCOPE O program O of O the O German B-ORG Academic I-ORG exchange I-ORG service I-ORG DAAD O 55931827 I-AWARD to O M.S O French B-ORG Ministry I-ORG of I-ORG Foreign I-ORG Affairs I-ORG PHC O N° I-AWARD 28351PC I-AWARD to O D.M O Institut O Pasteur O the O Centre O National O de O la O Recherche O Scientifique O the O Fondation B-ORG pour I-ORG la I-ORG Recherche I-ORG Médicale I-ORG FDT20150532465 O to O A.N O Doctoral O School O ‘Frontières O du O Vivant’ O funded O by O the O University O Paris O Descartes O Funding O for O open O access O charge O SLUB/TU O Dresden O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China(51867009 O to O ZQ O Foundation B-ORG Plan I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG in I-ORG Jiangxi I-ORG Province(20162BCB23045 O to O ZQ O Applied B-ORG and I-ORG Cultivation I-ORG Program I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG of I-ORG Jiangxi I-ORG Province(20181BBE58010 O to O ZQ O This O research O was O supported O by O the O National B-ORG Institute I-ORG of I-ORG Diabetes I-ORG and I-ORG Digestive I-ORG and I-ORG Kidney I-ORG Diseases I-ORG of O the O National O Institutes O of O Health O ML O grant O number O R01DK104348 B-AWARD and O the O Global O Obesity O Prevention O Center O GOPC O at O Johns O Hopkins O which O is O supported O by O the O Eunice B-ORG Kennedy I-ORG Shriver I-ORG National I-ORG Institute I-ORG of I-ORG Child I-ORG Health I-ORG and I-ORG Human I-ORG Development I-ORG and O the O Office O of O the O Director O National O Institutes O of O Health O ML, O grant O number O U54HD070725 B-AWARD Support O for O the O lead O author O was O provided O by O the O National B-ORG Cancer I-ORG Institute O Cancer O Related O Health O Disparities O Education O and O Career O Development O Program O CC, O grant O number O R25CA163184 B-AWARD NIH O grant O UL1TR000114 B-AWARD from O the O National B-ORG Center I-ORG for I-ORG Advancing I-ORG Translational I-ORG Sciences I-ORG NCATS O supported O data O management O The O content O is O solely O the O responsibility O of O the O authors O and O does O not O necessarily O represent O the O official O views O of O the O National O Institutes O of O Health O Funding O agencies O had O no O role O in O the O design O analysis O or O writing O of O this O manuscript O This O research O was O funded O by O Proyecto B-ORG de I-ORG Investigación I-ORG Dirección I-ORG Académica I-ORG Clínica I-ORG Las I-ORG Condes I-ORG PIDA O 2017-005 O D.Z O Fondo B-ORG Nacional I-ORG de I-ORG Desarrollo I-ORG Científico I-ORG y I-ORG Tecnológico I-ORG FONDECYT O 1211647 O Chile O R.V O Beca B-ORG de I-ORG Doctorado I-ORG Nacional I-ORG 21171030 B-AWARD D.I O Research O for O this O publication O was O supported O by O the O Centers B-ORG for I-ORG Disease I-ORG Control I-ORG and I-ORG Prevention I-ORG CDC O and O the O National B-ORG Cancer I-ORG Institute I-ORG NCI O cooperative O agreements O for O the O Cancer O Prevention O and O Control O Research O Networks O CPCRN O at O the O Harvard O School O of O Public O Health/Boston O School O of O Public O Health O U48DP001946 O National B-ORG Institute I-ORG for I-ORG Occupational I-ORG Safety I-ORG and I-ORG Health I-ORG for O the O Harvard O School O of O Public O Health O Center O for O Work O Health O and O Well-Being O U19 O OH008861 O the O Central O Texas O Cancer O Prevention O and O Control O Research O Network O CTxCPCRN O at O The O Texas O A&M O School O of O Public O Health O Center O for O Community O Health O Development O 5U48DP001924 O the O University O of O California O at O Los O Angeles O U48 B-AWARD DP001934 O Lisa O DiMartino’s O work O on O this O project O was O supported O by O the O National O Cancer O Institute O R25 O CA057726 I-AWARD The O authors O are O grateful O for O financial O support O from O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81601049 B-AWARD and O 21402010 B-AWARD Shandong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O ZR2019MB032 B-AWARD and O Technology B-ORG Project I-ORG of I-ORG Yantai I-ORG Nos O 2018XSCC048 B-AWARD and O 2019XDHZ108 B-AWARD This O research O was O supported O by O the O Gansu B-ORG Provincial I-ORG University I-ORG Teacher I-ORG Innovation I-ORG Fund I-ORG Project O grant O number O 2023A-051 B-AWARD the O Young B-ORG Supervisor I-ORG Fund I-ORG of I-ORG Gansu I-ORG Agricultural I-ORG University I-ORG grant O number O GAU-QDFC-2020-08 B-AWARD and O the O Gansu B-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG grant O number O 20JR5RA032 B-AWARD This O work O was O funded O byNational O Institute I-ORG of I-ORG Neurological I-ORG Disorders I-ORG and I-ORG Stroke10.13039/100000065grantsK23NS080988andR01NS097783‐03;National O Institute I-ORG on I-ORG Drug I-ORG Abuse10.13039/100000026grantR01DA019670;Vanderbilt O Institute I-ORG for I-ORG Clinical I-ORG and I-ORG Translational I-ORG Research10.13039/100007206grantNCATS/NIH O UL1 I-AWARD TR000445;National O Institute I-ORG on I-ORG Aging10.13039/100000049grantAG043458 O This O study O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2022YFF1003000 B-AWARD Applied B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Liaoning I-ORG Province I-ORG Grant O No. O 2022JH2/101300169 B-AWARD and O Scientific B-ORG Research I-ORG Fund I-ORG Project I-ORG of I-ORG Education I-ORG Department I-ORG of I-ORG Liaoning I-ORG Province I-ORG Grant O No. O LJKMZ20221024 B-AWARD This O work O was O also O supported O by O grants O from O the O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG of I-ORG MOF I-ORG and I-ORG MARA I-ORG CARS-12 O This O work O was O supported O by O grants O from O the O Strategic B-ORG Priority I-ORG Research I-ORG Programme I-ORG of I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG XDA08030203 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31130055 B-AWARD the O Independent B-ORG project I-ORG of I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Freshwater I-ORG Ecology I-ORG and I-ORG Biotechnology I-ORG 2014FBZ04 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O Faculty B-ORG of I-ORG Medicine I-ORG Srinakharinwirot I-ORG University I-ORG grant O no. O 274/2560 B-AWARD Srinakharinwirot O University O grant O no. O 629/2563 B-AWARD and O the B-ORG Center I-ORG of I-ORG Excellence I-ORG in I-ORG Probiotics I-ORG Srinakharinwirot I-ORG University I-ORG grant O no. O 212/2565 B-AWARD This O work O was O supported O by O the O Yunnan B-ORG Applied I-ORG Basic I-ORG Research I-ORG Projects-Kunming I-ORG Medical I-ORG University I-ORG Union I-ORG Foundation I-ORG 2018FE001(-132 O the O Top B-ORG Young I-ORG Talents I-ORG of I-ORG Yunnan I-ORG Ten I-ORG Thousand I-ORG Talents I-ORG Plan I-ORG YNWR-QNBJ-2018-286 O the O Innovative B-ORG Research I-ORG Team I-ORG of I-ORG Yunnan I-ORG Province I-ORG 2019(6 O the O Yunnan B-ORG Health I-ORG Training I-ORG Projects I-ORG of I-ORG Highly I-ORG Level I-ORG Talents I-ORG D-2017048 O and O the O Research B-ORG Project I-ORG of I-ORG Medical I-ORG and I-ORG Sanitary I-ORG Institution I-ORG of I-ORG Yunnan I-ORG Province I-ORG 2018NS0110 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the O Joint B-ORG Funds I-ORG of I-ORG National I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG and I-ORG the I-ORG Yunnan I-ORG Provincial I-ORG Government I-ORG no. O U1202261 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 31500194 B-AWARD the O CAS B-ORG 135 I-ORG programme I-ORG XTBG-F01 O T01 B-AWARD The O research O reported O in O Study O 1 O was O supported O by O a O Royal B-ORG Society I-ORG of I-ORG New I-ORG Zealand I-ORG Marsden I-ORG Fund I-ORG Grant I-ORG ID: O VUW B-AWARD 1321 I-AWARD to O Joseph O Bulbulia O Victoria O University O of O Wellington;http://www.royalsociety.org.nz/programmes/funds/marsden O and O a O Templeton B-ORG World I-ORG Charity I-ORG Foundation I-ORG Grant I-ORG ID: O 0077 B-AWARD to O CS;http://www.templetonworldcharity.org O The O last O author O is O supported O by O an O Australian B-ORG Research I-ORG Council I-ORG Future I-ORG Fellowship I-ORG FT150100147;http://www.arc.gov.au O The O funders O had O no O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG nos O 31372229 B-AWARD 31401991 B-AWARD and O 31420103902 B-AWARD the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG no. O 2013CB127600 B-AWARD the O Chinese B-ORG Universities I-ORG Scientific I-ORG Fund I-ORG nos O 2017QC100 B-AWARD 2017QC066 B-AWARD and O 2017ZB002 B-AWARD and O a O start-up O fund O from O the O University O of O Kentucky O The O information O reported O in O this O paper O no. O 17-08-055 O is O part O of O a O project O of O the O Kentucky O Agricultural O Experiment O Station O and O is O published O with O the O approval O of O the O Director O These O agencies O had O no O role O in O study O design O data O collection/analysis O manuscript O preparation O or O the O decision O to O publish O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No: O 31771676 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0700500 O the O Zhejiang B-ORG Province I-ORG Public I-ORG Technology I-ORG Research I-ORG Program I-ORG Project O No: O 2017C02027 B-AWARD This O work O was O supported O by O grants O from O the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 973 O Program O No. O 2014CB542300 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31271378 B-AWARD the O Research B-ORG Special I-ORG Fund I-ORG for I-ORG Public I-ORG Welfare I-ORG Industry I-ORG of I-ORG Health I-ORG No. O 201302018 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O BE2016737 B-AWARD This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 41573008 B-AWARD 41873015 B-AWARD 41573119 B-AWARD 41773011 B-AWARD and O U1612442 B-AWARD the O Guangdong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2017A030313247 O the O Environmental B-ORG Protection I-ORG Ministry I-ORG of I-ORG Public I-ORG Welfare I-ORG Research I-ORG Projects I-ORG 201509051 O the O Guangzhou B-ORG University’s O 2017 O training O program O for O young O top-notch O personnel O BJ201709 O and O the O 16th B-ORG “Challenge I-ORG Cup” I-ORG Undergraduate I-ORG Program I-ORG and I-ORG Provincial I-ORG Undergraduate I-ORG Training I-ORG Project I-ORG for I-ORG Innovation I-ORG 201811078128 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O Number O 2016YFC0905900 B-AWARD to O B.S O State B-ORG Key I-ORG Program I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O Number O 81430062 B-AWARD 81930086 B-AWARD to O B.S O and O Innovative B-ORG Research I-ORG Groups I-ORG of I-ORG the I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Grant O Number O 81521004 B-AWARD to O B.S O B.S O is O Yangtze O River O Scholar O of O Distinguished O Professor O This O work O was O supported O by O the O Crafoordska B-ORG Stiftelsen I-ORG 2013-0841];Greta O och I-ORG Johan I-ORG Kocks I-ORG stiftelser I-ORG 2014-231-401 O the B-ORG Research I-ORG Platform I-ORG for I-ORG Collaboration I-ORG for I-ORG Health I-ORG at I-ORG Kristianstad I-ORG University I-ORG 3/2014 O Gyllenstiernska B-ORG Krapperup I-ORG Foundation I-ORG 2013-00-16 O Vårdalstiftelsen B-ORG 2014-0127 O This O study O was O supported O by O the O Medical B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Shantou I-ORG City O of O Guangdong O Province O China O No. O 2018]121 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81571920 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2015A030313436 B-AWARD The O funding O were O not O involved O in O the O design O of O the O study O the O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O The O funding O was O used O as O costs O for O English O language O editing O service O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81503196 B-AWARD and O by O the B-ORG National I-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFC1706500 O and O by O the B-ORG Institute I-ORG of I-ORG Chinese I-ORG Materia I-ORG Medic I-ORG L2015018 O The O current O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81160358 B-AWARD Ningxia B-ORG medical I-ORG university I-ORG scientific I-ORG research I-ORG project I-ORG XY201621 O and O Top B-ORG Discipline I-ORG of I-ORG Public I-ORG Health I-ORG and I-ORG Prevent I-ORG Medicine I-ORG NXYLXK2017A08 O Education O Department O of O Ningxia O China O The O funders O had O no O role O in O the O study O design O data O collection O data O analysis O data O interpretation O or O writing O of O the O report O This O project O received O funding O from O the O European B-ORG Union’s I-ORG Horizon I-ORG 2020 I-ORG research I-ORG and I-ORG innovation I-ORG program I-ORG under O grant O agreement O no. O 739566 B-AWARD The O authors O acknowledge O financial O support O from O MICINN B-ORG under O projects O PID2020-115419GB-C21-C22/AEI/10.13039/501100011033 B-AWARD and O University B-ORG of I-ORG the I-ORG Basque I-ORG Country I-ORG Project O GIU21/006 B-AWARD This O research O was O supported O by O the O Main O Research O Program O of O the O Korea B-ORG Food I-ORG Research I-ORG Institute I-ORG E0170601-03 O and O the O World B-ORG Institute I-ORG of I-ORG Kimchi I-ORG KE2001-2 O funded O by O the O Ministry O of O Science O and O ICT O the O Basic O Science O Research O Program O of O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG 2018R1D1A1A09082921 O This O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81871971 B-AWARD and O 81772595 B-AWARD National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG grant O number O 2017YFC0908200 B-AWARD Sun B-ORG Yat-sen I-ORG University I-ORG Clinical I-ORG Research I-ORG 5010 I-ORG Program I-ORG grant O number O 2014013 B-AWARD Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG grant O number O 201803010117 B-AWARD Planning B-ORG Project I-ORG of I-ORG Guangdong I-ORG Province I-ORG grant O number O 2013B090800047 B-AWARD Young B-ORG Teacher I-ORG Foundation I-ORG of I-ORG Sun I-ORG Yat-sen I-ORG University I-ORG grant O number O 13ykpy46 B-AWARD This O study O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O Nos O 82060797 B-AWARD 81960796 B-AWARD 81860776 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Foundation I-ORG of I-ORG Guizhou I-ORG Province I-ORG No. O Qian B-AWARD kehejichu-ZK I-AWARD 2021 I-AWARD yiban I-AWARD 400 O the O Guizhou B-ORG Province I-ORG Department I-ORG of I-ORG Education I-ORG Youth I-ORG Science I-ORG and I-ORG Technology I-ORG Talent I-ORG Growth I-ORG Project I-ORG Guizhou O Education I-AWARD KY I-AWARD word I-AWARD 2021]195 O the O Guizhou B-ORG Administration I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG Projects I-ORG QZYY-2022-023 O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC I-ORG Special I-ORG Fund I-ORG for I-ORG Research I-ORG Innovation I-ORG and I-ORG Exploration I-ORG Projects I-ORG of I-ORG Guizhou I-ORG University I-ORG of I-ORG Chinese I-ORG Medicine I-ORG 2019YFC171250502 O and O the B-ORG Program I-ORG of I-ORG Innovative I-ORG Scientific I-ORG and I-ORG Technological I-ORG Talent I-ORG Team I-ORG of I-ORG Guizhou I-ORG Province I-ORG 2020-5010 O This O research O is O supported O by O the O NSFC-Shandong B-ORG Joint I-ORG Fund I-ORG for I-ORG Marine I-ORG Ecology I-ORG and I-ORG Environmental I-ORG Sciences I-ORG U1606404 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31272663 B-AWARD No. O 41176138 B-AWARD and O Qingdao B-ORG Post-doctor I-ORG Application I-ORG Research I-ORG Project I-ORG Y8KY01106N O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O AEI-MCII O grant O number O RTI2018-097189-B-C21 O to O A.F.M O and O A.F.C O by O UMH B-ORG grant O number O PAR-2019 B-AWARD to O A.F.M O by O AIRC B-ORG grant O number O IG B-AWARD 2016 I-AWARD Id.18631 I-AWARD to O G.C O by O MIUR B-ORG grant O number O PRIN B-AWARD 2017ZFJCS3 I-AWARD to O G.C O and O C.D O This O work O was O supported O by O Foundation O of O Liaoning B-ORG Educational I-ORG Committee I-ORG Grant O No. O LQ2017016 B-AWARD and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81300779 B-AWARD and O The B-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG 17DZ2260100 O This O research O was O supported O by O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2017YFD0202101 O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2015CB150506 O the B-ORG 111 I-ORG project I-ORG B12009 O the B-ORG Priority I-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG the I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O and O the B-ORG Innovative I-ORG Research I-ORG Team I-ORG Development I-ORG Plan I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China I-ORG IRT_17R56 O This O work O was O supported O by O Young B-ORG Scientists I-ORG Fund I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No.41301479 O University B-ORG Innovation I-ORG Talent I-ORG Support I-ORG Program I-ORG of I-ORG Liaoning I-ORG Province I-ORG No.LR2016061 O General B-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG of I-ORG Education I-ORG Department I-ORG of I-ORG Liaoning I-ORG Province I-ORG No. O LJCL009 O and O the O grant O recipient O of O all O the O funds O are O Quanhua O Zhao O Quanhua O Zhao O provides O the O main O idea O of O the O research O and O responsible O for O the O revision O of O the O manuscript O The O study O is O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O number O 2020YFC1316902 B-AWARD the O Eleventh B-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Program I-ORG of I-ORG China I-ORG grant O number O 2006BAI02A11 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 81572062 B-AWARD the O Twentieth B-ORG National I-ORG Science I-ORG the I-ORG Technology I-ORG Support I-ORG Program I-ORG of I-ORG China I-ORG grant O number O 2014BAI09B10 B-AWARD and O China B-ORG Scholarship I-ORG Council I-ORG 201806380006 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG nos O 41521001 B-AWARD 41877204 B-AWARD and O 41902265 B-AWARD the O 111 O Program O State O Administration I-ORG of I-ORG Foreign I-ORG Experts I-ORG Affairs I-ORG O the O Ministry O of O Education O of O China O B18049 B-AWARD and O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M642944 B-AWARD This O work O was O supported O by O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-44 O Agro-Technology B-ORG Demonstration I-ORG Program I-ORG IBP/IPM I-ORG 2130106 O and O The B-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG CAASASTIP-2015-IAR O This O research O was O supported O by O projects O PICT O 2013-1129 B-AWARD from O Agencia B-ORG Nacional I-ORG de I-ORG Investigaciones I-ORG Científicas I-ORG y I-ORG Tecnológicas O PIP B-AWARD 2014-2016 I-AWARD 11220130100005CO I-AWARD from O CONICET B-ORG and O project O PI09G B-AWARD from O Universidad B-ORG Nacional I-ORG de I-ORG La I-ORG Pampa O to O Ricardo O N O Melchor O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O National B-ORG Institutes I-ORG of I-ORG Health I-ORG U01AR073159 O R01AR044882 B-AWARD U54CA217378 B-AWARD in O part O National B-ORG Science I-ORG Foundation I-ORG DMS1763272 O Simons B-ORG Foundation I-ORG 594598 O to O Q.N O We O thank O the O Cancer B-ORG Prevention I-ORG and I-ORG Research I-ORG Institute I-ORG of I-ORG Texas I-ORG for O support O through O RR160005 B-AWARD and O the O American B-ORG Cancer I-ORG Society I-ORG for O support O through O RSG-18-006-01-CCE B-AWARD We O thank O the O National B-ORG Cancer I-ORG Institute I-ORG for O funding O through O R01CA138599 B-AWARD U01CA17470 B-AWARD 1U24 B-AWARD CA226110 O and O R01CA240589 B-AWARD We O thank O the O National B-ORG Institute I-ORG of I-ORG Biomedical I-ORG Imaging I-ORG and I-ORG Bioengineering I-ORG for O support O through O T32EB007507 B-AWARD S.J.L O is O supported O by O a O Cancer B-ORG Research I-ORG UK I-ORG 25 O C18281/A29019 O programme O grant O the O Integrative O Cancer O Epidemiology O Programme O and O by O the O NIHR B-ORG Bristol O Biomedical O Research O Centre O which O is O funded O by O the O NIHR O BRC-1215-20011 O M.A.Z O is O supported O by O Wellcome B-ORG Trust I-ORG 217446/Z/19/Z O This O work O was O supported O by O the O Italian B-ORG Ministry I-ORG of I-ORG Health I-ORG PE-2013-02355372 O Grant O Italian B-ORG Ministry I-ORG of I-ORG University I-ORG and I-ORG Research I-ORG PRIN O Grant I-AWARD 2010MEFNF7_002 O and O Italian B-ORG Space I-ORG Agency I-ORG COREA O Grant I-AWARD 2013-084-R.0 O Luca O Passamonti O is O funded O by O the O Medical B-ORG Research I-ORG Council I-ORG MRC O MR/P01271X/1 O at O the O University O of O Cambridge O UK. O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 21107100 B-AWARD the O International B-ORG Cooperation I-ORG Project I-ORG of O Zhengzhou O City O No. O 121PPTGG360-9 B-AWARD 141PGJHZ535 B-AWARD and O the O Natural B-ORG Science I-ORG Fund I-ORG for O Excellent O Young O Scholars O of O Zhengzhou O University O No. O 1421324067 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O authors O are O grateful O to O the O Youth B-ORG Mentor I-ORG Support I-ORG Fund I-ORG of I-ORG GAU I-ORG GAU-QNDS-201502 O the O National B-ORG Natural I-ORG Science I-ORG Fund I-ORG of I-ORG China I-ORG 31560442 O 31760466 O and O the O Natural B-ORG Science I-ORG Fund I-ORG of I-ORG Gansu I-ORG Province I-ORG 1606RJZA079 O for O financial O support O of O this O work O This O study O was O supported O by O Cooperative B-ORG Innovation I-ORG Center I-ORG of I-ORG Engineering I-ORG and I-ORG New I-ORG Products I-ORG for I-ORG Developmental I-ORG Biology I-ORG of I-ORG Hunan I-ORG Province I-ORG 20134486 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 30972623 O Open B-ORG Found I-ORG of I-ORG Hunan I-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG for I-ORG Molecular I-ORG Microbiology I-ORG 2014-04 O General B-ORG Foundation I-ORG of I-ORG Hunan I-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Department(2013SK3131 O and O Key B-ORG Project I-ORG of I-ORG Hunan I-ORG Province I-ORG Program I-ORG in I-ORG the I-ORG Field I-ORG of I-ORG Social I-ORG Development I-ORG 2015SK20331 O This O research O was O funded O by O Key-Area B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2020B1111030004 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 41890853 O the B-ORG Key I-ORG Special I-ORG Project I-ORG for I-ORG Introduced I-ORG Talents I-ORG Team I-ORG of I-ORG Southern I-ORG Marine I-ORG Science I-ORG and I-ORG Engineering I-ORG Guangdong I-ORG Laboratory I-ORG Guangzhou O GML2019ZD0401 O Hainan B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 321CXTD447 O This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFD0102001 O 2018YFD0100806 B-AWARD and O 2017YFD0101201 B-AWARD the O National O Transgenic O Major O Program O of O China O 2018ZX0800922B O and O 2018ZX0801006B O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31771875 O and O 31871702 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG of I-ORG China I-ORG 06500060 O FRF-TP-18-013A1 B-AWARD FRF-TP-18-014A1 B-AWARD the O “Ten O Thousand O Plan”-National O High O Level O Talents O Special O Support O Plan O For O Xiangyuan O Wan O and O the O Beijing B-ORG Talents I-ORG Foundation I-ORG No. O 2016000021223TD04 B-AWARD National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFA0504000 O to O C.C O and O W.E.D O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31822015 O 81870896 B-AWARD 31670801 B-AWARD to O Z.X.L O 91940302 B-AWARD 31500644 B-AWARD 31570792 B-AWARD to O W.E.D O 91849203 B-AWARD 31570857 B-AWARD to O C.C O Strategic O Priority O Research O Program O of O the O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG XDB19010203 O to O W.E.D O XDB39000000 B-AWARD to O C.C O Shanghai B-ORG Key I-ORG Laboratory I-ORG of I-ORG Embryo I-ORG Original I-ORG Diseases I-ORG Shelab201904 O to O Z.X.L O Funding O for O open O access O charge O National O Key O Research O and O Development O Program O of O China O 2017YFA0504000 O to O C.C O This O study O was O financially O supported O by O the O Natural B-ORG Science I-ORG Fund I-ORG of I-ORG China I-ORG 31402348 O National B-ORG Science I-ORG and I-ORG Technology I-ORG Support I-ORG Project I-ORG of I-ORG China I-ORG 2014BAD08B09 O and O National B-ORG Postdoctoral I-ORG Science I-ORG Fund I-ORG of I-ORG China I-ORG 2014M551747 O The O authors O were O supported O by O research O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Funding O support O National O Natural O Science O Foundation O of O China O 81571311 O to O Y.T O 81571331 B-AWARD to O F.W O National O Science O Fund O for O Distinguished O Young O Scholars O 81725005 O to O F.W O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG 2016YFC1306900 O to O Y.T O 2016YFC0904300 B-AWARD to O F.W O National B-ORG High I-ORG Tech I-ORG Development I-ORG Plan I-ORG 863 O 2015AA020513 O to O F.W O Liaoning B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 2015225018 O to O Y.T O Liaoning O Education O Foundation O Pandeng O Scholar O to O F.W O The O funders O had O no O influence O on O the O research O design O data O collection O data O analysis O interpretation O of O results O writing O the O manuscript O or O submitting O for O publication O This O research O was O supported O by O the O Zhejiang B-ORG Key I-ORG R&D I-ORG Program I-ORG No. O 2021C03085 B-AWARD the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2021YFC2100800 O the O Research B-ORG and I-ORG Application I-ORG Service I-ORG Platform I-ORG Project I-ORG of I-ORG API I-ORG Manufacturing I-ORG Environmental I-ORG Protection I-ORG and I-ORG Safety I-ORG Technology I-ORG in I-ORG China I-ORG 2020-0107-3-1 O Catalysis B-ORG Base I-ORG Construction I-ORG for I-ORG chemical I-ORG and I-ORG pharmaceutical I-ORG intermediates I-ORG 2019-00900-2-1 O the O Youth B-ORG Science I-ORG Fund I-ORG Project I-ORG of I-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 21906147 B-AWARD the O National O Natural O Science O Foundation O of O China O NSFC O Grant O No. O 21978273 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81602362 B-AWARD to O XG O the O program B-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG in I-ORG Henan I-ORG Province I-ORG No.162102310391 O to O XG O the O program B-ORG for I-ORG Young I-ORG Key I-ORG Teacher I-ORG of I-ORG Henan I-ORG Province I-ORG 2016GGJS-214 O to O XG O the O program B-ORG for I-ORG Innovative I-ORG Talents I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG in I-ORG Henan I-ORG Province I-ORG No. O 18HASTIT048 B-AWARD to O XG O the O supporting B-ORG grants I-ORG of I-ORG Henan I-ORG University I-ORG No.2015YBZR048 O No.yqpy20170039 O and O No.B2015151 O to O XG O and O Yellow B-ORG River I-ORG Scholar I-ORG Program I-ORG No.H2016012 O to O XG O The O funding O bodies O were O not O involved O in O the O study O design O data O collection O analysis O and O interpretation O of O data O or O in O writing O of O this O manuscript O This O work O was O supported O by O theMedical O Research I-ORG Council(MR/K019074/1to O G.C O and O O.V.P O theBritish O Heart I-ORG Foundation(PG/12/63/29824to O J.B.S O and O the O People O Programme O Marie O Curie O Actions O of O theEuropean O Union's I-ORG Seventh I-ORG Framework I-ORG Programme,FP7/2007-2013(Research O Executive O Agency O grant O agreement O no.608765to O T.A.J O Funding O to O pay O the O Open O Access O publication O charges O for O this O article O was O provided O by O the O Medical O Research O Council O 80 O and O the O British O Heart O Foundation O 20 O This O work O was O supported O by O Hasselt O University O Bijzonder B-ORG Onderzoeksfonds I-ORG Methusalem I-ORG Project I-ORG 08M03VGRJ B-AWARD JCW O acknowledges O USDA B-ORG AFRI I-ORG 2016-67021-24985 B-AWARD and O USDA B-ORG Hatch I-ORG CONH00147 B-AWARD W.S O S.T O and O N.W O were O research O fellows O and O a O postdoctoral O fellow O respectively O of O the O Research O Foundation-Flanders O FWO O This O research O was O financially O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG in I-ORG 2019 I-ORG No. O 2019YFC1904101 B-AWARD the B-ORG General I-ORG project I-ORG of I-ORG Fujian I-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2022J01922 O the B-ORG Initial I-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Fujian I-ORG University I-ORG of I-ORG Technology I-ORG GY-Z20014 O and O the B-ORG Research I-ORG Development I-ORG Foundation I-ORG of I-ORG Fujian I-ORG University I-ORG of I-ORG Technology I-ORG GY-Z18186 O This O study O was O financially O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Project O Number O 31302196 B-AWARD Wuhan B-ORG Morning I-ORG Light I-ORG Plan I-ORG of I-ORG Youth I-ORG Science I-ORG and I-ORG Technology I-ORG project O number O 2016070204010141 B-AWARD and O Chinese B-ORG National I-ORG College I-ORG Students I-ORG Innovation I-ORG Experiment I-ORG Program I-ORG project O number O 2015156 B-AWARD This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31472093 O to O Bo O Tang O PCSIRT B-ORG IRT_16R32 O to O Ziyi O Li, O and O National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Projects I-ORG 2014ZX-08-007-002-008 O to O Ziyi O Li. O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O S.S O wishes O to O acknowledge O financial O support O from O the O European B-ORG Research I-ORG Council I-ORG under O the O European B-ORG Union's I-ORG Horizon I-ORG 2020 I-ORG Framework I-ORG Programme I-ORG no. O FP/2014 B-AWARD 2020)/ERC O Grant O Agreement O no. O 739964 B-AWARD COPMAT O P.V.C O is O grateful O for O funding O from O the O MRC B-ORG Medical O Bioinformatics O project O MR/L016311/1 O EU B-ORG H2020 I-ORG CompBioMed O and O VECMA B-ORG Grant O nos O 675451 B-AWARD and O 800925 B-AWARD and O from O the O UCL O Provost O This O research O was O supported O by O the O Science B-ORG and I-ORG Technology I-ORG Basic I-ORG Resources I-ORG Investigation I-ORG Program I-ORG of I-ORG China I-ORG Grant O no. O 2018FY100304 B-AWARD the O Special B-ORG Project I-ORG of I-ORG Scientific I-ORG and I-ORG Technological I-ORG Basis I-ORG of I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG the I-ORG People’s I-ORG Republic I-ORG of I-ORG China I-ORG Grant O no. O 2006FY120100 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O no. O U1701246 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O in O part O by O a O grant O from O the O Shandong B-ORG Provincial I-ORG Modern I-ORG Agricultural I-ORG Industry I-ORG Technology I-ORG System I-ORG #SDAIT-21-05 O a O grant O from O Shandong B-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Program I-ORG 2014GSF121004 O a O grant O from O Shandong B-ORG Agricultural I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Project I-ORG CXGC2016B14 O and O a O grant O from O the B-ORG National I-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31570167 O The O funding O bodies O have O no O role O in O the O design O or O conclusion O of O the O study O J.S.C O is O a O Meinig O Family O Investigator O in O the O Life O Sciences O This O work O is O based O upon O research O conducted O at O the O Macromolecular O Diffraction O facility O at O the O Cornell O High O Energy O Synchrotron O Source O MacCHESS O beamlines O A1 O and O F1) O and O the O Northeastern O Collaborative O Access O Team O NE-CAT O beamlines O 24-ID-C O and O 24-I2D-E O under O general O user O proposals O GUP-51113 O and O GUP-41829 O PI: O J.S.C O CHESS O is O supported O by O an O award O from O the O National B-ORG Science I-ORG Foundation I-ORG DMR-1332208 O and O MacCHESS O is O supported O by O a O grant O from O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG GM-103485 O NE-CAT O beamlines O are O funded O by O the O National O Institute O of O General O Medical O Sciences O from O the O National O Institutes O of O Health O P30 O GM124165 O The O Pilatus O 6M O detector O on O 24-ID-C O beam O line O is O funded O by O a O NIH-ORIP B-ORG HEI I-ORG grant I-ORG S10 O RR029205 O This O research O used O resources O of O the O Advanced O Photon O Source O a O U.S O Department O of O Energy O DOE O Office O of O Science O User O Facility O operated O for O the O DOE O Office O of O Science O by O Argonne O National O Laboratory O under O Contract O No. O DE-AC02-06CH11357 O Funding O for O open O access O charge O Laboratory O startup O funds O This O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Fund I-ORG Grant O No. O 31471718 B-AWARD the O Agriculture B-ORG Department I-ORG of I-ORG China I-ORG Grant O No. O CARS-30 B-AWARD and O the O Northwestern B-ORG Polytechnical I-ORG University I-ORG No. O 201410699086 B-AWARD and O No. O 3102014GEKY1010 B-AWARD This O research O was O supported O by O Ateneo O Sapienza O Sapienza B-ORG University I-ORG of I-ORG Rome I-ORG Italy O grant O number O RP11715C541D4BFF B-AWARD and O RP11816418C88AAC B-AWARD to O MMB O grant O number O RM11816413C50F4B B-AWARD to O RN O and O TR; O Israel B-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG MOST I-ORG Italy I-ORG Ministry I-ORG of I-ORG Foreign I-ORG Affairs I-ORG MAECI O grant O number O 3–9022 B-AWARD to O EP O and O TR; O Israel B-ORG Science I-ORG Foundation O grant O number O 162/17 B-AWARD for O EP. O The O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31702179 O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG 2412020FZ017 O a O grant O from O the O Jilin O Provincial O Development O and O Reform O Commission O 2020C037-5 O and O the O Program B-ORG of I-ORG Introducing I-ORG Talents I-ORG of I-ORG Discipline I-ORG to I-ORG Universities I-ORG B16011 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81600006 O and O 81671887 B-AWARD Sichuan B-ORG Provincial I-ORG Scientific I-ORG Grant I-ORG 2017SZ0110 O Shanghai B-ORG Science I-ORG and I-ORG Technology I-ORG Committee I-ORG Rising-Star I-ORG Program I-ORG 19QA1408500 O and O Training B-ORG Plan I-ORG of I-ORG Excellent I-ORG Young I-ORG Medical I-ORG Talents I-ORG in I-ORG Shanghai I-ORG 2017YQ015 O The O funding O body O played O no O roles O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O research O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32202568 O and O Beijing B-ORG Academy I-ORG of I-ORG Agriculture I-ORG and I-ORG Forestry I-ORG Sciences I-ORG KJCX20230808 O and O QNJJ202317 B-AWARD China O This O work O was O partially O funded O by O Beijing B-ORG Natural I-ORG Science I-ORG Fundation I-ORG 623008 O and O China B-ORG agriculture I-ORG research I-ORG system I-ORG CARS-20 O This O study O was O supported O by O grants O from O the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province(recipient O Chenjin O Jin O award O number:2012B061700081 O the O Fundamental B-ORG Research I-ORG Funds I-ORG of I-ORG the I-ORG State I-ORG Key I-ORG Laboratory I-ORG of I-ORG Ophthalmology I-ORG recipient O Kunbei O Lai O award O number:2016QN06 O the O Medical B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG recipient O Kunbei O Lai O award O number:A201633),the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG recipient O Kunbei O Lai O award O number:2016A030310212 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG recipient O Kunbei O Lai O award O number:81600741 O The O funding O organizations O had O no O role O in O the O study O design O conduct O of O this O research O data O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O numbers O 62071258 B-AWARD and O 61971246 B-AWARD and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Inner I-ORG Mongolia I-ORG Autonomous I-ORG Region O grant O numbers O 2020ZD18 B-AWARD and O 2021MS06005 B-AWARD and O the O Major B-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG Inner I-ORG Mongolia I-ORG Autonomous I-ORG Region O grant O numbers O 2019ZD022 B-AWARD This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31470370 B-AWARD and O No. O 31670277 B-AWARD the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG No. O 2016YFD0100901 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG LQ17C020001 O and O the O 1000-Talents O Plan O for O Young O Researchers O of O China O R.H O is O a O Wellcome O Investigator O 109915/Z/15/Z O supported O by O the O Wellcome O Centre O for O Mitochondrial O Research O 203105/Z/16/Z O who O receives O support O from O the O Medical B-ORG Research I-ORG Council I-ORG UK) O MR/N025431/1 O the O European B-ORG Research I-ORG Council I-ORG 309548 O and O the O Mitochondrial O European O Educational O Training O MEET O ITN O MARIE O CURIE O PEOPLE O 317433 O H.L O receives O funding O from O the O European B-ORG Union I-ORG Seventh I-ORG Framework I-ORG Programme I-ORG FP7/2007–2013 O under O grant O agreement O No. O 305444 B-AWARD RD-Connect O 305121 B-AWARD Neuromics O the O Wellcome B-ORG Trust I-ORG Pathfinder O Scheme O 201064/Z/16/Z O and O the O Newton B-ORG Fund I-ORG UK/Turkey O MR/N027302/1 O H.J.G O A.R O and O R.P.Z O acknowledge O the O financial O support O by O the O Ministeriumfür O Innovation O Wissenschaft O und O Forschung O des O Landes O Nordrhein-Westfalen O the O SenatsverwaltungfürWirtschaft O Technologie O und O Forschung O des O Landes O Berlin O and O the O BundesministeriumfürBildung O und O Forschung O H.G.J O further O thanks O the O CAPES O Foundation O for O financial O support O This O work O was O financed O by O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG province I-ORG BK20130838 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51409086 O TW B-ORG and I-ORG FJ I-ORG Vegetable I-ORG Germplasm I-ORG Resources I-ORG Industry I-ORG Extension I-ORG Program I-ORG KF2015110 O and O the O Innovation B-ORG and I-ORG Service I-ORG Platform I-ORG of I-ORG Facility I-ORG Vegetable I-ORG Seed I-ORG Industry I-ORG in I-ORG Fuzhou I-ORG China I-ORG 2017-PT-113 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O RETICS O Red O de O Trastornos O Adictivos O RD12/0028/0021 O RD16/0017/0001 B-AWARD funded O by O Instituto B-ORG de I-ORG Salud I-ORG Carlos I-ORG III I-ORG ISC-III I-ORG and I-ORG European I-ORG Regional I-ORG Development I-ORG Funds-European I-ORG Union I-ORG ERDF-EU O Research O projects O funded O by O Ministerio B-ORG de I-ORG Economía I-ORG y I-ORG Competitividad I-ORG and I-ORG ISC-III I-ORG PI13/02261 O and O PI16/01953 B-AWARD Research O projects O funded O by O Ministerio B-ORG de I-ORG Sanidad I-ORG Servicios I-ORG Sociales I-ORG e I-ORG Igualdad I-ORG and I-ORG Plan I-ORG Nacional I-ORG sobre I-ORG Drogas I-ORG 049/2009 O and O 049/2013 B-AWARD Research O project O funded O by O Consejería B-ORG de I-ORG Economía I-ORG Innovación I-ORG y I-ORG Ciencia I-ORG Junta I-ORG de I-ORG Andalucía I-ORG and I-ORG ERDF-EU I-ORG CTS-433 O Research O projects O funded O by O Consejería B-ORG de I-ORG Salud I-ORG y I-ORG Bienestar I-ORG Social I-ORG Junta I-ORG Andalucía I-ORG PI0228-2013 O and O PI0823 B-AWARD 2012 O Antonia O Serrano O and O Francisco O Javier O Pavón O hold O Miguel O Servet O research O contracts O funded O by O ISC-III B-ORG and I-ORG ERDF-EU I-ORG CP14/00173 O and O CP14/00212 B-AWARD respectively O Pablo O Romero-Sanchiz O holds O a O ‘Río O Hortega’ O research O contract O funded O by O ISC-III B-ORG and I-ORG ERDFEU I-ORG CM13/0115 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O grants O from O the O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2013CB911303 O 2011CB910703 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31470810 O 31071235 O the O Science O and I-ORG Technology I-ORG Department I-ORG of I-ORG Sichuan I-ORG Province I-ORG 2017JY0232 O and O the O Health B-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG Sichuan I-ORG Province I-ORG 17ZD045 O This O work O was O supported O by O the O Thailand B-ORG Research I-ORG Fund I-ORG Grant O RTA6080003 B-AWARD SCC O the O NSTDA O Research B-AWARD Chair I-AWARD Grant I-AWARD from O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Agency I-ORG Thailand O NC O and O the O Chiang B-ORG Mai I-ORG University I-ORG Center B-AWARD of I-AWARD Excellence I-AWARD Award I-AWARD NC O This O work O was O supported O by O the O National B-ORG Cancer I-ORG Institute I-ORG Outstanding I-ORG Investigator I-ORG Award I-ORG R35CA197745 O the O NCI B-ORG Cancer I-ORG Target I-ORG Discovery I-ORG and I-ORG Development I-ORG Program I-ORG U01CA168426 O and O two B-ORG NIH I-ORG Shared I-ORG Instrumentation I-ORG Grants I-ORG S10 O OD012351 I-AWARD and O S10 B-AWARD OD021764 O all O to O Andrea O Califano O Aaron O T. O Griffin O was O supported O in O part O by O the O Ruth B-ORG L. I-ORG Kirschstein I-ORG National I-ORG Research I-ORG Service I-ORG Award I-ORG NRSA I-ORG Institutional I-ORG Research I-ORG Training I-ORG Grant O 5T32GM007367-43 O and O in O part O by O the O NCI B-ORG Ruth I-ORG L. I-ORG Kirschstein I-ORG National I-ORG Research I-ORG Service I-ORG Award I-ORG Individual I-ORG Fellowship I-ORG F30CA257765 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 3202013014 O the O Project B-ORG of I-ORG Yazhouwan I-ORG Scientific I-ORG and I-ORG Technological I-ORG Administration I-ORG of I-ORG Sanya I-ORG SYND-2021-18 O SYND-2022-20 B-AWARD the O Yantai B-ORG institute I-ORG of I-ORG China I-ORG Agricultural I-ORG University I-ORG Z202206 O and O the O Construction B-ORG of I-ORG Beijing I-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG and I-ORG Service I-ORG Capacity I-ORG in I-ORG Priority I-ORG Subjects I-ORG CEFF-PXM2019_014207_000032 O This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81372787 O 81072136 O Shanghai B-ORG Municipal I-ORG Bureau I-ORG of I-ORG Health I-ORG 20134033 O Shanghai B-ORG Health I-ORG System I-ORG joint I-ORG research I-ORG project I-ORG 2013ZYJB0201 O and O Top B-ORG 100 I-ORG Medical I-ORG Elite I-ORG in I-ORG Shanghai I-ORG XBR O 2011065 O This O study O was O supported O by O Key B-ORG Scientific I-ORG and I-ORG Technological I-ORG Project I-ORG of I-ORG Meizhou I-ORG People’s I-ORG Hospital O Grant O No O MPHKSTP-20180101 B-AWARD to O Dr. O Zhixiong O Zhong O and O the O Guangdong B-ORG Provincial I-ORG Key I-ORG Laboratory I-ORG of I-ORG Precision I-ORG Medicine I-ORG and I-ORG Clinical I-ORG Translation I-ORG Research I-ORG of I-ORG Hakka I-ORG Population I-ORG Grant O No O 2018B030322003 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Meizhou I-ORG Grant O No O 2019B0202001 B-AWARD This O research O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG 22JHQ075 O Shaanxi B-ORG Natural I-ORG Science I-ORG Basic I-ORG Research I-ORG Project I-ORG 2022JM-542 O 2021JM-502 B-AWARD Xi’an B-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG Project I-ORG 22GXFW0122 O and O Xi’an B-ORG Association I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 095920221366 O This O study O was O supported O by O the O West B-ORG Light I-ORG Foundation I-ORG of I-ORG the I-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG No. O 2020]82 B-AWARD Key B-ORG technology I-ORG projects I-ORG of I-ORG Inner I-ORG Mongolia I-ORG Autonomous I-ORG Region I-ORG Grant O No. O 2020GG0306 B-AWARD Science B-ORG and I-ORG Technology I-ORG Plan I-ORG Projects I-ORG of I-ORG Alxa I-ORG League I-ORG Grant O No. O AMY2020-18 B-AWARD and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Gansu I-ORG Province I-ORG No. O 21JR7RA038 B-AWARD This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 51603235 B-AWARD 51673219 B-AWARD 51773229 B-AWARD and O 51873235 B-AWARD the O Scientific O and O Technological O Program O of O Guangdong O Province O grant O number O 2017A010103008 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG grant O number O 2018B030311017 B-AWARD and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG grant O number O 181gpy41 B-AWARD DL O is O funded O by O theNational O Institute I-ORG for I-ORG Health I-ORG Research[DRF-2018-11-ST2-016 O This O work O was O supported O by O a O grant O from O theWellcome O Trust[109823/Z/15/Z O to O KIM O EJT O is O funded O by O theMedical O Research I-ORG Council(MC_UU_12017/13 O and O MC_UU_12017/15 B-AWARD andChief O Scientist I-ORG Office(SPHSU13 O and O SPHSU15 B-AWARD and O by O aChief O Scientist I-ORG Office I-ORG Clinical I-ORG Academic I-ORG Fellowship(CAF/17/11 O RWA O was O supported O by O the O Wellcome O Trust O through O aClinical O Research I-ORG Career I-ORG Development I-ORG Fellowship[206602 O Fabian O Cieplik O thanks O for O funding O by O the O Deutsche B-ORG Forschungsgemeinschaft I-ORG German O Research O Foundation O Grant O number O CI B-AWARD 263/2-1 O by O the O Deutsche B-ORG Gesellschaft I-ORG für I-ORG Zahn I-ORG Mund I-ORG und I-ORG Kieferheilkunde I-ORG German O Association O for O Dental O Oral O and O Maxillofacial O Medicine O science B-AWARD fund O and O by O the O Universitätsklinikum O Regensburg O University O Medical I-ORG Center I-ORG Regensburg O ReForM B-AWARD B I-AWARD Program O This O work O was O supported O by O the B-ORG Basic I-ORG Core I-ORG Technology I-ORG Development I-ORG Program I-ORG for I-ORG the I-ORG Oceans I-ORG and I-ORG the I-ORG Polar I-ORG Regions I-ORG of I-ORG the I-ORG National I-ORG Research I-ORG Foundation I-ORG of I-ORG Korea(NRF O funded O by O the O Ministry O of O Science O ICT O 2015M1A5A1037055 O and O by O the B-ORG National I-ORG Research I-ORG Foundation I-ORG of I-ORG Korea(NRF I-ORG grant I-ORG funded I-ORG by I-ORG the I-ORG Korea I-ORG government(MSIT O No. O 2016R1A2B3011422 B-AWARD and O by O the B-ORG Nano·Material I-ORG Technology I-ORG Development I-ORG Program I-ORG through I-ORG the I-ORG National I-ORG Research I-ORG Foundation I-ORG of I-ORG Korea(NRF I-ORG funded I-ORG by I-ORG the I-ORG Ministry I-ORG of I-ORG Science I-ORG ICT I-ORG and I-ORG Future I-ORG Planning I-ORG No. O 2016M3A7B4910555 B-AWARD This O work O is O financially O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG no. O 2016YFA0601400 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG no. O 41306132 B-AWARD and O the O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG no. O 2014AA021701 B-AWARD This O study O is O a O contribution O to O the O international O IMBER O project O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31560572 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Province I-ORG China I-ORG 20171BAB214030 O the O Youth B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Provincial I-ORG Department I-ORG of I-ORG Education I-ORG China I-ORG GJJ160393 O and I-AWARD GJJ180172 O and O the O Jiangxi B-ORG Province I-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG China I-ORG 2016KY06 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the B-ORG CAMS I-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG CIFMS O No. O 2017-I2M-3-021 B-AWARD the B-ORG CAMS I-ORG Project I-ORG for I-ORG Reform I-ORG of I-ORG Scientific I-ORG Research I-ORG System I-ORG 2017-TZGG-16 O and O the B-ORG Sichuan I-ORG Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG Nos O 2017JY0064 B-AWARD and O 2019YJ0280 B-AWARD This O research O was O funded O by O Key B-ORG R&D I-ORG Projects I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2021C02007 O the O Zhejiang B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Program I-ORG on I-ORG Agricultural I-ORG New I-ORG Variety I-ORG Breeding I-ORG 2021C02068 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG C170105/31501966 O and O the O earmarked O fund O for O Modern B-ORG Agro-industry I-ORG Technology I-ORG Research I-ORG System I-ORG China I-ORG CARS-35 O This O work O was O funded O by O the O Bijzonder B-ORG Onderzoeksfonds I-ORG of I-ORG the I-ORG KU I-ORG Leuven I-ORG PF/10/014 O Centre B-AWARD of I-AWARD Excellence O by O the O Interdisciplinair B-ORG Ontwikkelingsfonds I-ORG I-ORG Kennisplatform I-ORG Centre O of O Excellence O KP/12/009 B-AWARD and O by O the O Fonds B-ORG voor I-ORG Wetenschappelijk I-ORG Onderzoek-Vlaanderen I-ORG G0846.11 O and O Vascular O Biology O Network O M.H O is O a O post-doctoral O fellow O of O the O Fonds O voor O Wetenschappelijk O Onderzoek-Vlaanderen O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O supported O by O the O Research B-ORG Project I-ORG of I-ORG Fundación I-ORG CajaCanarias I-ORG ‘FOTOCAT’ I-ORG AER01 O the B-ORG Research I-ORG project I-ORG of I-ORG Fundación I-ORG CajaCanarias I-ORG ‘MAGEC’ I-ORG AYE06 O and O the B-ORG Spanish I-ORG Ministry I-ORG of I-ORG Economy I-ORG and I-ORG Competitiveness I-ORG projects O ENE2013-47826-C4-1-R B-AWARD ENE2013-47826-C4-4-R B-AWARD P.M.R O would O like O to O thank O Santander O Universidades O for O its O financial O support O through O ‘@ O Becas O Iberoamérica O Jóvenes O Profesores O e O Investigadores O España O 2016’ O scholarship O program O This O research O was O funded O by O China B-ORG Agriculture I-ORG Research I-ORG System I-ORG CARS-37 O Tibet B-ORG Autonomous I-ORG Region I-ORG Science I-ORG Fund I-ORG ZDZX2018000043 O and O The B-ORG Tibet I-ORG Autonomous I-ORG Region I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG 2023 I-ORG Key I-ORG R I-ORG I-ORG D I-ORG Program I-ORG XZ202301ZY0016N O This O work O was O financially O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Chongqing I-ORG grant O numbers O cstc2017jcyjAX0225 B-AWARD cstc2018jcyjA0864 O the O Medicinal B-ORG and I-ORG Healthy I-ORG Technology I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province O China O grant O numbers O 2017KY642 B-AWARD and O Science B-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Huzhou I-ORG grant O numbers O 2017GY32 B-AWARD This O research O was O funded O by O the O National B-ORG Social I-ORG Science I-ORG Fund I-ORG of I-ORG China O grant O numbers O 22BJY094 B-AWARD and O 22BGL169 B-AWARD the O General B-ORG Project I-ORG of I-ORG Humanities I-ORG and I-ORG Social I-ORG Sciences I-ORG Research I-ORG of I-ORG Ministry I-ORG of I-ORG Education I-ORG of I-ORG China O grant O number O 19YJC630166 B-AWARD the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation O grant O number O 2021M693573 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG of I-ORG China O grant O number O 2022JJ30080 B-AWARD the O Project B-ORG of I-ORG Social I-ORG Science I-ORG Achievement I-ORG Review I-ORG Committee I-ORG of I-ORG Hunan I-ORG Province I-ORG of I-ORG China O grant O number O XSP22YBC221 B-AWARD and O the O Research B-ORG Foundation I-ORG of I-ORG Educational I-ORG Commission I-ORG of I-ORG Hunan I-ORG Province I-ORG of I-ORG China O grant O number O 22A0174 B-AWARD Tasha O R. O Stanton O was O supported O by O a O Canadian B-ORG Institute I-ORG for I-ORG Health I-ORG Research I-ORG Postdoctoral I-ORG Training I-ORG Fellowship I-ORG ID223354 O and O a O National B-ORG Health I-ORG I-ORG Medical I-ORG Research I-ORG Council I-ORG Early I-ORG Career I-ORG Fellowship I-ORG ID1054041 O G. O Lorimer O Moseley O was O supported O by O a O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG Research I-ORG Fellowship I-ORG ID1061279 O This O work O was O supported O by O a O University O of O South O Australia O Internal O Research O Grant O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O the O Bundesministerium B-ORG für I-ORG Bildung I-ORG und I-ORG Forschung I-ORG Berlin-Brandenburg O research O platform O BB3R O 031A262A B-AWARD R.B.R O thanks O the O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG de I-ORG São I-ORG Paulo I-ORG FAPESP O 2016/02195-1 B-AWARD for O the O international O fellowship O C.H O gratefully O acknowledges O SFB O 1112 O and O Elsa-Neumann O doctoral O scholarships O K.V O M.S O and O A.K O were O financially O supported O by O Czech B-ORG Science I-ORG Foundation I-ORG 16-25687J O and O EFSA-CDN O No. O CZ.02.1.01/0.0/0.0/16_019/0000841 O co-funded O by O ERDF O Open B-AWARD Access I-AWARD funding I-AWARD provided O by O the O Freie B-ORG Universität I-ORG Berlin I-ORG This O work O was O supported O by O QUT’s O Faculty O of O Health O Catapult O grant I-AWARD to O Makrina O Totsika O and O Kathryn O E. O Fairfull-Smith O and O the O Asian B-ORG Office I-ORG of I-ORG Aerospace I-ORG Research I-ORG and I-ORG Development I-ORG Grant O No. O FA2386-16-1-4094 B-AWARD R&D O 16IOA094 O The O authors O gratefully O acknowledge O funding O support O from O the O Australian B-ORG Research I-ORG Council’s O Future O Fellowship O Scheme O FT140100746 O to O Kathryn O E. O Fairfull-Smith O Queensland B-ORG University I-ORG of I-ORG Technology I-ORG Vice-Chancellor’s O Research O Fellowship O to O Makrina O Totsika O and O the O Australian B-ORG Government I-ORG Research B-AWARD Training I-AWARD Program I-AWARD RTP I-AWARD Scholarship I-AWARD to O Anthony O D. O Verderosa O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21772240 O the O Chinese B-ORG Academy I-ORG of I-ORG Science I-ORG YJKYYQ20170036 O and O Guangzhou B-ORG Science I-ORG Technology I-ORG and I-ORG Innovation I-ORG Commission I-ORG 201707010210 O 201604020019 O Tian-Yu O Zhang O received O the O Science O and O Technology O Innovation O Leader O of O Guangdong O Province O 2016TX03R095 O This O study O was O funded O by O the O Natural B-ORG Science I-ORG Fund I-ORG Project I-ORG of I-ORG Zhangzhou I-ORG City I-ORG No. O ZZ2017J19 B-AWARD the B-ORG key I-ORG natural I-ORG fund I-ORG project I-ORG of I-ORG the I-ORG university I-ORG youth I-ORG of I-ORG Fujian I-ORG province I-ORG No. O JZ160454 B-AWARD Natural B-ORG Science I-ORG Fund I-ORG Project I-ORG of I-ORG Fujian I-ORG Province I-ORG No. O 2016J05083 B-AWARD and O Program B-ORG for I-ORG New I-ORG Century I-ORG Excellent I-ORG Talents I-ORG in I-ORG Minnan I-ORG Normal I-ORG University I-ORG No. O MX13004 B-AWARD This O study O was O supported O by O Research B-ORG project I-ORG of I-ORG Jiangsu I-ORG Provincial I-ORG natural I-ORG science I-ORG foundation I-ORG No. O BK20151595 B-AWARD Jiangsu B-ORG Provincial I-ORG Medical I-ORG Youth I-ORG Talent I-ORG No. O QNRC2016542 B-AWARD and O Jiangsu B-ORG Provincial I-ORG Major I-ORG Science I-ORG I-ORG Technology I-ORG Demostation I-ORG Project I-ORG No. O BE2017749 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O financially O supported O by O the O Southwest B-ORG Hospital I-ORG Key I-ORG Program I-ORG SWH2016ZDCX2014 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81372082 B-AWARD National B-ORG Special I-ORG Scientific I-ORG Projects I-ORG of I-ORG Public I-ORG Welfare I-ORG Industry I-ORG Funding I-ORG of I-ORG China I-ORG No. O 201502028 B-AWARD and O the O State B-ORG Key I-ORG Laboratory I-ORG Funding I-ORG SKLZZ201221 O This O study O is O part O of O TCM B-ORG Research I-ORG Project I-ORG of I-ORG Guangdong I-ORG Provincial I-ORG Hospital I-ORG of I-ORG Chinese I-ORG Medicine I-ORG YN2015MS25 O and O supported O by O MOST/SATCM B-ORG of I-ORG the I-ORG People’ I-ORG s I-ORG Republic I-ORG of I-ORG China I-ORG grant O 2013BAI02B04 B-AWARD and O the O State B-ORG Administration I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG P.R I-ORG China I-ORG No. O 201007005 B-AWARD The O sponsor O will O not O have O a O role O in O the O design O conduct O or O interpretation O of O the O study O or O in O any O decision O to O submit O the O manuscript O for O publication O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81903724 B-AWARD grant O from O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangxi I-ORG Province I-ORG No. O 20171BAB215078 B-AWARD 20181BBG70008 B-AWARD and O China B-ORG ‘Creation I-ORG of I-ORG New I-ORG Drugs’ I-ORG Key I-ORG Technology I-ORG Projects I-ORG No. O 2009ZX09103 B-AWARD This O work O was O supported O by O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O grant O funded O by O the O Korean O government O MSIT O No. O NRF-2019R1F1A1059972 B-AWARD and O 2019 B-AWARD Research I-AWARD Grant I-AWARD from O Kangwon B-ORG National I-ORG University O This O work O was O also O partially O supported O by O Brain O Pool O Program O through O NRF O by O the O Ministry O of O Science O and O ICT O in O Korea O No. O 2019H1D3A2A01101691 B-AWARD NRF O grant O No. O NRF-2019M3F3A1A02071969 O and O NRF-2019M3F3A1A02071966 O and O the O MOTIE O Ministry O of O Trade O Industry O and O Energy O in O Korea O under O the O Fostering O Global O Talents O for O Innovative O Growth O Program O P0008750 O supervised O by O the O Korea B-ORG Institute I-ORG for I-ORG Advancement I-ORG of I-ORG Technology I-ORG KIAT O This O research O was O funded O by O Research B-ORG Special I-ORG Fund I-ORG for I-ORG Public I-ORG Welfare I-ORG Industry I-ORG of I-ORG Health I-ORG NO. O 201202004 B-AWARD FCZ O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO. O 81172857 B-AWARD 81373188 I-AWARD 81302591;http://www.nsfc.gov.cn/publish/portal1 O YZL O Chinese B-ORG National I-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG Ministry I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG NO. O 2011AA02A113;http://www.most.gov.cn/eng B-AWARD YZL O Key B-ORG Projects I-ORG in I-ORG the I-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG Pillar I-ORG Program I-ORG in I-ORG the I-ORG Twelfth I-ORG Five-year I-ORG Plan I-ORG Period I-ORG NO. O 2014BAI07B00;http://www.most.gov.cn/eng B-AWARD YZL O Capital B-ORG Health I-ORG Research I-ORG and I-ORG Development I-ORG of I-ORG Special I-ORG Fund I-ORG NO. O 2014-1-4011 B-AWARD YZL O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O Funding O was O provided O by O Royal B-ORG Society I-ORG Grant O No. O WM130118 B-AWARD National B-ORG Institutes I-ORG of I-ORG Health I-ORG Research I-ORG Grant O No. O Birmingham B-AWARD Biomedical I-AWARD Research I-AWARD Centre O Medical B-ORG Research I-ORG Council I-ORG Grant O No. O PhD B-AWARD Studentship O This O work O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Funding I-ORG of I-ORG China I-ORG Grant O Nos O 31570035 B-AWARD and O 31670093 B-AWARD the B-ORG Tianjin I-ORG Natural I-ORG Science I-ORG Funding I-ORG Grant O Nos O 17JCZDJC32100 B-AWARD and O 18JCYBJC24500 B-AWARD and O the B-ORG Postdoctoral I-ORG Science I-ORG Funding I-ORG of I-ORG China I-ORG Grant O No. O 2018M631729 B-AWARD This O work O was O supported O by O National B-ORG Sci-Tech I-ORG key I-ORG project I-ORG 2018ZX10733402 O and I-AWARD 2017ZX10103010 O Yunnan B-ORG Science I-ORG and I-ORG Technology I-ORG Talent I-ORG and I-ORG Platform I-ORG Program I-ORG 2017HC019 O Yunnan B-ORG Joint I-ORG Support I-ORG for I-ORG National I-ORG Program I-ORG 2015GA009 O Yunnan B-ORG Province I-ORG Major I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG 2017ZF007 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O U1702282 O The O funders O have O no O role O in O the O design O collection O analysis O interpretation O of O data O and O in O writing O the O manuscript O of O the O study O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51374121 B-AWARD and O funded O by O Liaoning B-ORG Distinguished I-ORG Professor I-ORG 551710007007 O funded O project B-ORG of I-ORG the I-ORG Liaoning I-ORG Million I-ORG Talents I-ORG project I-ORG 2019-45-15 O and O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Liaoning I-ORG Province I-ORG 2019-MS-162 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O The O commercial O company O ’ O Power O China O Hua O Dong O Engineering O Corporation O Limited’ O provided O support O in O the O form O of O salaries O for O the O author O Mingyu O Wang O but O did O not O have O any O additional O role O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O No. O 11672198 B-AWARD Six B-ORG Talent I-ORG Peaks I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province O GDZB-050 B-AWARD and O Foundation B-ORG project I-ORG of I-ORG Jiangsu I-ORG Advanced I-ORG Textile I-ORG Engineering I-ORG Technology I-ORG Center O No. O XJFZ/2018/15 B-AWARD The O supports O from O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG of I-ORG China I-ORG 2017YFC0603004 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 51678220 O the O Program B-ORG for I-ORG Innovation I-ORG Scientists I-ORG and I-ORG Technicians I-ORG Troop I-ORG Construction I-ORG Projects I-ORG of I-ORG Henan I-ORG Province I-ORG in O China O CXTD2017088 O and O the O Program O for O Innovative O Research O Team O in O Science O and O Technology O 19IRTSTHN027 O in O Henan O Polytechnic O University O are O appreciated O The O authors O appreciate O the O support O from O the O Engineering O division O in O New O York O University O Abu O Dhabi O UAE O This O research O was O funded O by O Guangdong B-ORG Natural I-ORG Science I-ORG Foundation I-ORG research I-ORG team I-ORG project I-ORG S2013030011515 O Guangdong B-ORG Provincial I-ORG Hospital I-ORG of I-ORG Chinese I-ORG Medicine I-ORG Science I-ORG and I-ORG Technology I-ORG Research I-ORG Program I-ORG YK2013B1N11 O and O Guangdong B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG 2013B090700015 O Those O funding O body O were O not O involved O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81600716 O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Plan I-ORG of I-ORG Zhejiang I-ORG Province I-ORG Science I-ORG and I-ORG Technology I-ORG Hall I-ORG 2017C03046 O General B-ORG Scientific I-ORG Research I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG Education I-ORG Department I-ORG Y201738741 O The O research O has O been O funded O by O MARSYMBIOMICS B-ORG project I-ORG Spanish O MINECO I-AWARD CTM2013-43287-P O BluePharmTrain B-ORG FP7 O People-INT I-AWARD Ref I-AWARD 2013-667786 O and O Grup B-ORG Consolidat I-ORG SGR-120 B-AWARD to O Maria O J. O Uriz O Leire O Garate O benefited O from O a O fellowship O within O the O Benthomics B-ORG project I-ORG Spanish O MICINN I-AWARD CTM-2010-22218-C02-01 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O Japan B-ORG Society I-ORG for I-ORG the I-ORG Promotion I-ORG of I-ORG Science I-ORG Grants-in-Aid I-ORG for I-ORG Scientific I-ORG Research I-ORG Grant O Number O 19K07860 B-AWARD to O M.M.-S O and O JP26117005 B-AWARD to O M.H O Japan B-ORG Science I-ORG and I-ORG Technology I-ORG Agent I-ORG Core I-ORG Research I-ORG for I-ORG Evolutional I-ORG Science I-ORG and I-ORG Technology I-ORG CREST O Grant O Number O JPMJCR18H3 B-AWARD to O M.H O and O Japan B-ORG Agency I-ORG for I-ORG Medical I-ORG Research I-ORG and I-ORG Development I-ORG Brain/MINDS I-ORG Grant O Number O JP18dm0207019 B-AWARD to O M.H O and O U.K B-ORG Medical I-ORG Research I-ORG Council I-ORG Grant O Number O MC_U105184291 B-AWARD to O M.G O Work O at O Fundación O Jiménez O Díaz O University O Hospital O was O supported O by O grants O from O the O Spanish B-ORG Ministry I-ORG of I-ORG Economy I-ORG and I-ORG Competitiveness I-ORG MINECO O AES O program O PI15/00934 B-AWARD PI18/00382 B-AWARD and O the O Ministry B-ORG of I-ORG Health I-ORG Spanish O Biomedical O Research O Center O in O Cancer O CIBERONC O CB16/12/0241 B-AWARD Iván O Prieto-Potin O is O supported O by O the O Fundación B-ORG Jiménez I-ORG Díaz I-ORG Biobank I-ORG grant O PT13/0010/0012 B-AWARD and O Federico O Rojo O is O the O recipient O of O grants O from O the O Institute B-ORG of I-ORG Health I-ORG Carlos I-ORG III I-ORG ISCIII/FEDER I-ORG intensification I-ORG program I-ORG ProteoRed I-ORG PRB2-ISCIII B-AWARD PT13/0001 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81501933 O 81572214 B-AWARD Wenzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG Y20160369 O Scientific B-ORG research I-ORG project I-ORG for I-ORG student I-ORG of I-ORG Wenzhou I-ORG Medical I-ORG University I-ORG WYX201401020 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Zhejiang I-ORG Province I-ORG LY14H060008 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O aWellcome O Trust I-ORG clinical I-ORG training I-ORG fellowshipawarded O to O Victoria O Keevil O 092077/Z/10/Z O and O by O programme O grants O from O theMedical O Research I-ORG Council I-ORG MRC)(grant O numbers O G9502233 B-AWARD G0401527),Cancer B-AWARD Research I-ORG UK(grant O number O C864/A8257 B-AWARD andResearch O into I-ORG Ageing(grant O number O 262 B-AWARD NJW O is O also O supported O by O the O MRC O grant O numbers O MC_UU_12015/3 B-AWARD MC_UU_12015/4 B-AWARD This O study O was O supported O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81373621 O 81774166 B-AWARD Funded B-ORG by I-ORG a I-ORG Municipal I-ORG Human I-ORG Resources I-ORG Development I-ORG Program I-ORG for I-ORG Outstanding I-ORG Leaders I-ORG in I-ORG Medical I-ORG Disciplines I-ORG in I-ORG Shanghai I-ORG 2017BR044 O Sponsored B-ORG by I-ORG Shanghai I-ORG Sailing I-ORG Program I-ORG 17YF1419700 O This O research O was O supported O by O the B-ORG Youth I-ORG Foundation I-ORG of I-ORG the I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG BK20210614 O the B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32071784 O and O the B-ORG Priority I-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O This O work O was O supported O by O the O Grant B-ORG Agency I-ORG of I-ORG the I-ORG Czech I-ORG Republic I-ORG 18-15548S O the O Ministry O of O Education O Youth O and O Sports O of O the O Czech O Republic O in O the O “National O Feasibility O Program O I” O LO1208 O TEWEP O EU B-ORG structural I-ORG funding I-ORG Operational I-ORG Programme I-ORG Research I-ORG and I-ORG Development I-ORG for I-ORG innovation O project O No. O CZ.1.05/2.1.00/19.0388 B-AWARD and O project O SGS/09/PrF/2019 B-AWARD financed O by O University B-ORG of I-ORG Ostrava I-ORG This O study O was O financially O supported O by O Projects O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 52004342 O Innovation-Driven B-ORG Project I-ORG of I-ORG Central I-ORG South I-ORG University I-ORG 150240015 O and O Natural B-ORG Science I-ORG Fund I-ORG for I-ORG Outstanding I-ORG Young I-ORG Scholar I-ORG of I-ORG Hunan I-ORG Province I-ORG China I-ORG 2021JJ20065 O This O research O was O funded O by O grants O from O the O Ningxia B-ORG Hui I-ORG Nationality I-ORG Autonomous I-ORG Region I-ORG Major I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG 2020BCF01003 O the O National O Key B-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG 2019YFD1002500 O and O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG Shanxi I-ORG Province I-ORG 2020 O ZDLNY07–08 O This O work O was O supported O by O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81700043 O 81520108001 I-AWARD 81770043 O the B-ORG 973 I-ORG Key I-ORG Scheme I-ORG of I-ORG China I-ORG 2015CB553406 O Guangdong B-ORG Province I-ORG Universities I-ORG and I-ORG Colleges I-ORG Pearl I-ORG River I-ORG Scholar I-ORG Funded I-ORG Scheme I-ORG 2014 O W I-AWARD Lu O Guangzhou B-ORG Department I-ORG of I-ORG Education I-ORG for I-ORG Innovative I-ORG Team I-ORG 13C08 O and O Guangdong B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2016A030313593 O and O State B-ORG Key I-ORG Laboratory I-ORG of I-ORG Respiratory I-ORG Disease I-ORG Foundation I-ORG SKLRD-QN-201719 O The O funding O sponsors O had O no O role O in O the O design O of O the O study O in O the O collection O analyses O or O interpretation O of O data O in O the O writing O of O the O manuscript O and O in O the O decision O to O publish O the O results O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21703114 O 51773102 B-AWARD Key B-ORG Research I-ORG Project I-ORG of I-ORG Shandong I-ORG Province I-ORG 2018GGX102011 O as O well O as O Foundation O of O Qingdao O University O 41117010117 O and O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shandong I-ORG Province I-ORG ZR2016BP03 O This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 21773148 O 21306111 I-AWARD 21327011 O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Shaanxi I-ORG Province I-ORG 2018JM2003 O 2018JM2016 O and O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG GK1301030235 O GK201803040 O This O study O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFD0100903 O the O National B-ORG Program I-ORG of I-ORG Transgenic I-ORG Variety I-ORG Development I-ORG of I-ORG China I-ORG 2016ZX08001-002 O and O the O Shandong B-ORG Modern I-ORG Agricultural I-ORG Technology I-ORG I-ORG Industry I-ORG system I-ORG SDAIT-17-06 O This O research O was O funded O by O Universiti B-ORG Kebangsaan I-ORG Malaysia I-ORG UKM I-ORG Grant O number O LIV-2015-05 B-AWARD and O GGPM-2018-063 B-AWARD Ministry B-ORG of I-ORG Science I-ORG Technology I-ORG and I-ORG Innovation I-ORG MOSTI I-ORG of I-ORG Malaysia I-ORG Grant O no O ScienceFund B-AWARD 02-01-02-SF1279 O and O Ministry B-ORG of I-ORG Higher I-ORG Education I-ORG of I-ORG Malaysia I-ORG FRGS/2/2014/ST04/UKM/03/1 O This O study O was O supported O by O grants O from O the B-ORG National I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 81772901 O 81602447 B-AWARD 81301757 B-AWARD the B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG Grant O No. O 2015JJ2191 B-AWARD 2015JJ3161 B-AWARD and O the B-ORG Research I-ORG Fund I-ORG for I-ORG the I-ORG Doctoral I-ORG Program I-ORG of I-ORG Higher I-ORG Education I-ORG Grant O No. O 20130162120083 B-AWARD The O acquisition O analysis O and O interpretation O of O the O data O and O the O writing O of O the O manuscript O supported O by O the O grants O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81471329 B-AWARD National B-ORG Science I-ORG and I-ORG Technology I-ORG Major I-ORG Project I-ORG No. O 2016YFC1000707 B-AWARD and O Public B-ORG health I-ORG program I-ORG of I-ORG Capital I-ORG No. O Z141100002114001 B-AWARD This O research O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51508030 B-AWARD the O National B-ORG Key I-ORG R. I-ORG and I-ORG D. I-ORG Program I-ORG of I-ORG China I-ORG No. O 2017YFB0309903 B-AWARD the O Basic B-ORG Research I-ORG Project I-ORG of I-ORG Natural I-ORG Science I-ORG in I-ORG Qinghai I-ORG Province I-ORG No. O 2017-ZJ-715 B-AWARD Key O Research O and O Development O Program O of O Shaanxi O Province O No. O 2018SF-403 B-AWARD 2018SF-380 O the O Basic O Research O Project O of O Natural O Science O in O Shaanxi O Province O Nos O 2019JQ-559 B-AWARD 2019JQ-380 O 2018JQ5146 O and O the O Fundamental O Research O Funds O for O the O Central O Universities O of O China O No. O 300102318401 O The O manuscript O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81621064 O and O 81702934 B-AWARD CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG CIFMS O 2016-I2M-02-002 O and O National B-ORG Key I-ORG R&D I-ORG Plan I-ORG 2018ZX09711001-007-002 O Shijiazhuang B-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG funded O this O research O Grant O No. O 201460603 B-AWARD This O work O was O also O supported O by O financial O grants O from O the O National O Natural O Science O Foundation O of O China O 82274582 O Hebei B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG H2019106063 O Hebei O Province O Innovation O capability O Improvement O plan O project O 20577715D O and O the B-ORG S&T I-ORG Program I-ORG of I-ORG Hebei I-ORG 19277701D O This O study O was O supported O by O several O sources:10.13039/501100001862Svenska O Forskningsrådet I-ORG Formas(2017-01996_3 O and O 2017-02001),10.13039/501100001674Fondation B-AWARD Leducq(17CVD01 O the10.13039/501100004359Swedish O Research I-ORG Council I-ORG Vetenskapsrådet O and O grants O from O the O Swedish O state O under O an O agreement O between O the O Swedish O government O and O the O county O councils O the O ALF-agreement O ALFGBG O 718101 O F.B O is O a O Torsten O Söderberg O Professor O of O Medicine O and O recipient O of O an O ERC O Consolidator O Grant O 10.13039/100010663European O Research I-ORG Council O Consolidator O grant O 615362-METABASE B-AWARD This O research O was O funded O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 62171481 B-AWARD National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O number O 2019YFE0114000 B-AWARD Special B-ORG Support I-ORG Program I-ORG of I-ORG Guangdong I-ORG grant O number O 2019TQ05X150 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG grant O number O 2021A1515011124 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG under O Grant O 202201011577 B-AWARD Work O at O LOA O was O supported O by O the O European B-ORG Research I-ORG Council I-ORG M-PAC O project O Contract O No. O 715807 B-AWARD Simulations O were O performed O on O the O UCLA O Hoffman2 O cluster O through O NSF B-ORG OCI-1036224 B-AWARD Work O at O UCLA O was O supported O by O DOE B-ORG Contracts O No. O DE-SC0010064 B-AWARD No. O DE-SC0008491 O No. O DE-SC0008316 O and O NSF O Contracts O No. O PHY-1415386 B-AWARD No. O PHY-1734315 B-AWARD No. O ACI-1339893 B-AWARD No. O PHY-0960344 B-AWARD Work O at O SLAC O was O supported O by O DOE O Contract O No. O DE-AC02-76SF00515 B-AWARD This O study O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG grant O no. O 2019A1515011652 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O No. O 81903132 B-AWARD the O Outstanding B-ORG Youth I-ORG Development I-ORG Scheme I-ORG of I-ORG Nanfang I-ORG Hospital I-ORG Southern I-ORG Medical I-ORG University I-ORG grant O no. O 2019J006 B-AWARD and O the O President B-ORG Foundation I-ORG of I-ORG Nanfang I-ORG Hospital I-ORG Southern I-ORG Medical I-ORG University I-ORG grant O no. O 2018C001 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the B-ORG National I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2017YFE0103800 O the O National O Institutes O of O Health O National O Institute I-ORG of I-ORG Allergy I-ORG and I-ORG Infectious I-ORG Diseases I-ORG 1R01AI114310 B-AWARD UNC-South O China O STD O Research O Training O Centre O Fogarty O International I-ORG Centre I-ORG 1D43TW009532 B-AWARD UNC O Center O for O AIDS O Research O National O Institute O of O Allergy O and O Infectious O Diseases O 5P30AI050410 O University O of O California O San O Francisco O Center O for O AIDS O Research O National O Institute O of O Allergy O and O Infectious O Diseases O P30 O AI027763 O and O the O Bill O O Melinda O Gates O Foundation O to O the O Mesh O Consortium O BMGF-OPP1120138 O This O publication O was O also O supported O by O Grant O Number O UL1TR001111 O from O the O National O Center O for O Advancing O Translational O Sciences O NCATS O at O the O National O Institutes O of O Health O Medical O Scientific O Research O Foundation O of O Guangdong O Province O of O China(A2018508 O The O listed O grant O funders O played O no O role O in O any O step O of O this O study O This O study O was O supported O by O projects O of O International B-ORG Cooperation I-ORG and I-ORG Exchanges I-ORG NSFC I-ORG 51561145014 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2015M571316 O and O the O National B-ORG Key I-ORG Laboratory I-ORG project I-ORG of I-ORG Microbial I-ORG Metabolism I-ORG MMLKF16-04 O This O work O is O supported O by O the O Key B-ORG Technologies I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of O China O 2019YFB1311501 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61773280 O Engineering B-ORG and I-ORG Physical I-ORG Sciences I-ORG Research I-ORG Council I-ORG EP/P027938/1 O EP/R004080/1 O and O Wellcome/EPSRC O Centre O for O Interventional O and O Surgical O Sciences O WEISS O at O UCL O 203145Z/16/Z O Danail O Stoyanov O is O supported O by O a O Royal O Academy O of O Engineering O Chair O in O Emerging O Technologies O CiET1819/2/36 O and O an O EPSRC O Early O Career O Research O Fellowship O EP/P012841/1 O This O work O was O supported O by O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 2016ZX350036 B-AWARD National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81603027 B-AWARD and O the O CAMS B-ORG Innovation I-ORG Fund I-ORG for I-ORG Medical I-ORG Sciences I-ORG No. O 2017-I2M-2-004 B-AWARD We O also O thank O “Universities O and O Colleges O Key O Programs O for O Foreign O Talent” O of O State B-ORG Administration I-ORG of I-ORG Foreign I-ORG Experts I-ORG Affairs I-ORG P.R I-ORG China I-ORG No. O T2017069 B-AWARD We O are O grateful O to O OpenEye O Scientific O Software O for O providing O an O academic O license O for O their O packages O and O the O support O by O District B-ORG of I-ORG Columbia I-ORG Developmental I-ORG Center I-ORG for I-ORG AIDS I-ORG Research I-ORG No. O P30AI087714 B-AWARD This O study O was O funded O by O the O MarinERA O project O “Marine O phylogeographic O structuring O during O climate O change O the O signature O of O leading O and O rear O edge O of O range O shifting O populations” O by O the O Eco-Ethology B-ORG Research I-ORG Unit’ I-ORG Strategic I-ORG Plan I-ORG PEst-OE/MAR/UI0331/2011 O now O included O in O MARE B-ORG UID/MAR/04292/2013 O and O by O CCMAR B-ORG Strategic I-ORG Plan I-ORG PEst-C/MAR/LA0015/2011 O and O UID/Multi/04326/2013 B-AWARD from O Fundação O para O a O Ciência O e O a O Tecnologia—FCT O partially O FEDER O funded O RLC O was O supported O by O a O postdoctoral O fellowship O from O FCT—Portuguese B-ORG Science I-ORG Foundation I-ORG SFRH/BPD/109685/2015 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31670612 O 31971628 B-AWARD 31870291 B-AWARD 31300568 B-AWARD 31370595 B-AWARD and O 31571347 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Yunnan I-ORG Province I-ORG 2016FB033 O the O Programme O of O the O Chinese B-ORG Academy I-ORG of I-ORG Sciences I-ORG kfj-brsn-2018-6-008 O and O 2017XTBG-T02 B-AWARD and O the O Guangdong B-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG 2016A030313642 O This O research O was O funded O by: O Regione B-ORG Campania-“Packaging O innovativi O a O base O di O pEptidi O antimicRobici O per O la O SIcurezza O Alimentare” O PERSIA O project O grant O number O POR B-AWARD FESR I-AWARD CAMPANIA I-AWARD 2014/2020 I-AWARD n. O B63D18000530007 O Ministero B-ORG della I-ORG Salute-“Attività O battericida O ed O anti-biofilm O di O nano-sistemi O ibridi O coniugati O con O peptidi O antimicrobici O una O nuova O strategia O per O la O formulazione O di O bio-sanitizzanti O contro O ceppi O patogeni O resistenti” O Ricerca O Corrente O 2017 O project O grant O number O IZS B-AWARD ME I-AWARD 06/18 I-AWARD RC; O Regione O Campania O “Produzione O di O principi O attivi O da O organismi O “estremofili” O in O colture O vegetali O ed O algali O strategie O industriali O innovative O per O produzioni O green O ecosostenibili” O PRESTIGE O project O grant O number O POR B-AWARD FESR I-AWARD Campania I-AWARD 2014/2020 O Ministero B-ORG dello I-ORG Sviluppo I-ORG Economico-“Sviluppo O di O piattaforme O molecolari O e O cellulari O per O l’identificazione O di O prodotti O innovativi O adattività O NUTRAceutica O da O Biotrasformazioni O mediante O organismi O ESTremofili” O NUTRABEST O project O grant O number O PON B-AWARD I&C I-AWARD 2014-2020 I-AWARD n. I-AWARD F/200050/01-03/X45 I-AWARD This O study O was O supported O in O part O by O a B-ORG Grant-in-Aid I-ORG for I-ORG Cancer I-ORG Research I-ORG from I-ORG the I-ORG Ministry I-ORG of I-ORG Education I-ORG Culture I-ORG Sports I-ORG and I-ORG Technology O Japan O #18K08799 O the B-ORG Project B-ORG for I-ORG Cancer I-ORG Research I-ORG and I-ORG Therapeutic I-ORG Evolution I-ORG P-CREATE O grant O number O JP20cm0106402 B-AWARD to O T.O O and O Project O for O Cancer O Research O and O Therapeutic O Evolution O P-PROMOTE O grant O number O 22ama221405h0001 B-AWARD to O Y.Y O from O the O Japan O Agency O for O Medical O Research O and O Development O AMED O This O work O was O supported O by O funding O from O the O Top B-ORG Science I-ORG and I-ORG Technology I-ORG Talents I-ORG Scheme I-ORG of I-ORG Yunnan I-ORG Province I-ORG 2009CI123 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31370595 O and O the O CAS B-ORG 135 I-ORG Program I-ORG XTBG-T02 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O grants O from O the O National B-ORG Cancer I-ORG Center I-ORG 1010470 O in O design O of O the O study O the O collection O analysis O and O interpretation O of O data O and O the O National O R&D O Program O for O Cancer O Control O Ministry B-ORG of I-ORG Health I-ORG I-ORG Welfare I-ORG Republic I-ORG of I-ORG Korea I-ORG 1320330 O in O the O writing O of O the O manuscript O in O the O decision O to O submit O the O manuscript O for O publication O and O by O the O R&D O Program O for O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG 20100028631 O in O the O interpretation O of O data O This O work O was O supported O by O the O Social B-ORG Science I-ORG Foundation I-ORG of I-ORG the I-ORG Shaanxi I-ORG Province I-ORG of I-ORG China O under O Grant O Nos O 2021K014 B-AWARD 2020K016 B-AWARD 2021K007 B-AWARD the O Natural B-ORG Science I-ORG Basic I-ORG Research I-ORG Plan I-ORG of I-ORG the I-ORG Shaanxi I-ORG Province I-ORG of I-ORG China I-ORG under O Grant O No. O 2022JM-324 B-AWARD and O Shaanxi B-ORG Province I-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG under O Grant O No. O 2022ZDLSF07-07 B-AWARD This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China O grant O Nos O 61974126 B-AWARD 51902273 I-AWARD and I-AWARD 11904302 O the O Science O and O Technology O Project O of O Fujian O Province O grant O Nos O 2018H6022 O 2019HZ020013 O and O 2019H6004 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province O grant O No. O 2018J01103 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities O grant O No. O 20720190005 B-AWARD and O the O Strait O Post-doctoral O Foundation O of O Fujian O Province O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 71473034 B-AWARD the O Heilongjiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O LH2019G001 B-AWARD and O the O financial O assistance O from O Postdoctoral B-ORG Scientific I-ORG Research I-ORG Developmental I-ORG Fund I-ORG of I-ORG Heilongjiang I-ORG Province I-ORG Grant O No. O LBH-Q16003 B-AWARD All O these O fundations O were O received O by O Mingyang O Wang O And O these O fundations O have O played O great O role O in O study O design O data O collection O and O analysis O decision O to O publish O and O preparation O of O the O manuscript O This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 71774178 B-AWARD Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Grant O No. O 2017A020212006 B-AWARD the B-ORG Guangzhou I-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG Grant O No. O 201607010368 B-AWARD and O Community-based B-ORG integrated I-ORG interventions I-ORG for I-ORG the I-ORG prevention I-ORG and I-ORG control I-ORG of I-ORG AIDS I-ORG hepatitis I-ORG B I-ORG and I-ORG tuberculosis I-ORG in I-ORG Guangdong I-ORG China I-ORG Grant O No. O 2018ZX10715004 B-AWARD This O study O was O financially O supported O in O part O by O the O Key O Program O of O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31330079 O the B-ORG Innovation I-ORG Scientists I-ORG and I-ORG Technicians I-ORG Troop I-ORG Construction I-ORG Projects I-ORG of I-ORG Henan I-ORG Province I-ORG 134200510012 O the B-ORG Key I-ORG National I-ORG Science I-ORG and I-ORG Technology I-ORG Specific I-ORG Projects I-ORG 2012ZX10004220-001 O and O President B-ORG Foundation I-ORG of I-ORG Tarim I-ORG University I-ORG TDZKJC201601 O This O study O is O supported O by O National B-ORG High I-ORG Technology I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2012AA02A509 O National B-ORG Key I-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG 2011CB504000 O and O Beijing B-ORG Science I-ORG and I-ORG Technology I-ORG Committee I-ORG Funding I-ORG D131100005313008 O This O study O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grantor O Yaqiu O Lin O 32072723 B-AWARD and O the O Sichuan B-ORG Science I-ORG and I-ORG Technology I-ORG Program I-ORG grantor O Yaqiu O Lin O 2022JDTD0030 B-AWARD and O by O the O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Southwest I-ORG Minzu I-ORG University I-ORG grantor O Yaqiu O Lin O 2021057 B-AWARD This O research O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81571658 I-AWARD to I-AWARD X. I-AWARD X. I-AWARD Du O the O National O Natural O Science O Foundation O of O China O 81271302 O to O J.R O Liu O the B-ORG Research I-ORG Innovation I-ORG Project I-ORG from I-ORG Shanghai I-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG No. O 14JC1404300 O to O J.R O Liu O the O “Prevention O and I-ORG Control I-ORG of I-ORG Chronic I-ORG Diseases I-ORG Project” O of O Shanghai O Hospital O Development O Center O No. O SHDC12015310 O to O J.R O Liu O a O project O from O SHSMU-ION B-ORG Research I-ORG Center I-ORG for I-ORG Brain I-ORG Disorders I-ORG No. O 2015NKX006 O to O J.R O Liu O a O project O from O Shanghai O Municipal O Education O Commission—Gaofeng O Clinical I-ORG Medicine I-ORG Grant I-ORG Support I-ORG No. O 20161422 I-AWARD to O J. O R. O Liu O a B-ORG Clinical I-ORG Research I-ORG Project I-ORG from I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University I-ORG School I-ORG of I-ORG Medicine I-ORG No. O DLY201614 I-AWARD to I-AWARD J.R I-AWARD Liu O and O the B-ORG Biomedicine I-ORG Key I-ORG Program I-ORG from I-ORG Shanghai I-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG No. O 16411953100 I-AWARD to O J.R O Liu O The O authors O would O like O to O acknowledge O the O financial O support O of O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 61904021 O the O foundation B-ORG of I-ORG Chongqing I-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG grant O NO. O ckrc B-AWARD 2021070 O and O the O Regional B-ORG Joint I-ORG Fund I-ORG of I-ORG Guangdong I-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Fund—Youth I-ORG Fund I-ORG Project I-ORG 2019A1515111072 O This O work O was O supported O by O the B-ORG Interreg I-ORG IIIA I-ORG Kvarken-MittSkandia I-ORG Program I-ORG IKM O 3.4 I-AWARD 20-03 O the B-ORG Bothnia-Atlantica I-ORG Program I-ORG 304-200809348 O both O funded O by O the O European O Union O and O the O European O Regional O Development O Fund O This O work O was O also O supported O by O the B-ORG Swedish I-ORG Research I-ORG Council I-ORG K2014-99X-22610-01-6 O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 21606109 B-AWARD the O Jiangsu B-ORG Key I-ORG Laboratory I-ORG of I-ORG Advanced I-ORG Food I-ORG Manufacturing I-ORG Equipment I-ORG I-ORG Technology I-ORG No. O FMZ202002 B-AWARD and O the O Postgraduate B-ORG Research I-ORG I-ORG Practice I-ORG Innovation I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O KYCX19_1862 B-AWARD The O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81972381 B-AWARD the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG grant O nos O 2017YFC1002001 B-AWARD and I-AWARD SQ2018YFC100243 O the O Beijing B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 7182177 O and O the O Beijing B-ORG Municipal I-ORG Science I-ORG I-ORG Technology I-ORG Commission I-ORG grant O no. O Z151100003915105 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O material O is O based O upon O work O supported O by O the O U.S B-ORG National I-ORG Science I-ORG Foundation O under O Grant O Nos O DBI-0850223 B-AWARD DEB-0956049 I-AWARD DBI-1356381 I-AWARD DEB-1353252 I-AWARD and O Grant O No. O DEB-0072713 B-AWARD to O B.L B-ORG Fisher I-ORG and I-ORG C.E I-ORG Griswold I-ORG and O Grant O No. O DEB-0344731 B-AWARD to O B.L B-ORG Fisher I-ORG and I-ORG P.S I-ORG Ward O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81925001 O the B-ORG Innovation I-ORG Program I-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Education I-ORG Commission I-ORG 202101070007-E00097 O Program B-ORG of I-ORG Shanghai I-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG 21DZ2201800 O Bethune B-ORG Charitable I-ORG Foundation I-ORG BJ-RW2020001J O Innovative O research O team O of O high-level O local O universities O in O Shanghai O and O Innovative O team O of O Shanghai O Pulmonary O Hospital O This O work O was O supported O by O the O Natural B-ORG Science I-ORG Foundation I-ORG for I-ORG Distinguished I-ORG Young I-ORG Scholars I-ORG of I-ORG Fujian I-ORG Province I-ORG project O no. O 2015D012 B-AWARD Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG project O no. O 2014D003 B-AWARD the B-ORG Medical I-ORG Innovation I-ORG Foundation I-ORG of I-ORG Fujian I-ORG Province I-ORG project O no. O 2014-CXB-46 B-AWARD and O the B-ORG Science I-ORG and I-ORG Technology I-ORG Project I-ORG of I-ORG Xiamen I-ORG City I-ORG project O no. O 3502Z20164029 B-AWARD This O study O was O supported O by O the O National B-ORG Institute I-ORG of I-ORG Biological I-ORG Resources I-ORG NIBR O funded O by O the O Ministry O of O Environmental O of O the O Republic O of O Korea O NIBR201527101 O the O National B-ORG Research I-ORG Foundation I-ORG of O Korea O Grant O funded O by O the O Korean O Government O 2016R1A2B4013627 O and O 2016R1D1A1B03930394 B-AWARD and O partly O supported O by O Chonnam B-ORG National I-ORG University I-ORG 2017-2859 O Deutsche B-ORG Forschungsgemeinschaft I-ORG DFG O German O Research O Foundation O KH O 263/1 O KH263/2 B-AWARD Heisenberg O Grant O KH263/5 B-AWARD to O A.K O SFB1631 B-AWARD INST O 247/926 O to O A.K O and O T.C O Ressort O Forschung O und O Lehre O University O Medical O Center O of O the O Johannes O Gutenberg O University O Mainz O S1 O Grant O to O A.K O European B-ORG Union I-ORG EU) O OnkoTher-H O Grant O ESF/14-BM-A55 B-AWARD to O S.E O Damp B-ORG Foundation I-ORG grant O 2017-05 B-AWARD to O S.E O International O PhD O Programme O IPP O Mainz O Fellowship O to O M.R O Funding O for O open O access O charge O DFG O German O Research O Foundation O This O work O was O supported O by O Research B-ORG fund I-ORG of I-ORG National I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Commission I-ORG of I-ORG China I-ORG Project O 201402004 B-AWARD Guangxi B-ORG National I-ORG Science I-ORG Foundation I-ORG Project O 2013GXNSFAA019258 B-AWARD a O project O grant O from O the O Research B-ORG Foundation I-ORG of I-ORG Guangxi I-ORG Medical I-ORG and I-ORG Health I-ORG Project O S201612 B-AWARD and O a O project O grant O from O the O Self-raised B-ORG Foundation I-ORG of I-ORG Guangxi I-ORG Health I-ORG Commission I-ORG Project O Z20170777 O This O work O was O funded O by O the O Major B-ORG Program I-ORG of I-ORG the I-ORG “12th I-ORG Five-Year I-ORG Plan” I-ORG for I-ORG Medical I-ORG Development I-ORG of I-ORG PLA I-ORG 14CXZ002 O the O General B-ORG Program I-ORG of I-ORG the I-ORG “12th I-ORG Five-Year I-ORG Plan” I-ORG for I-ORG Medical I-ORG Development I-ORG of I-ORG PLA I-ORG CWS12J015 O the O Second B-ORG Military I-ORG Medical I-ORG University I-ORG 2016 I-ORG Annual I-ORG PhD I-ORG Innovative I-ORG Research I-ORG Fund I-ORG 20152049 O and O financial O support O from O the O China B-ORG Scholarship I-ORG Council I-ORG 201603170127 O the B-ORG Military I-ORG Medical I-ORG Program I-ORG of I-ORG Second I-ORG Military I-ORG Medical I-ORG University I-ORG 2014JS20 O and O the O Shanghai B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG 2013Y168 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O or O writing O the O manuscript O This O study O was O funded O by O the O following O the O National B-ORG Nature I-ORG Science I-ORG Foundations I-ORG of I-ORG China I-ORG NSFC O No. O 12175153 B-AWARD No. O 12075156 B-AWARD the O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation O 2021A1515010048 B-AWARD and O 2019A1515011474 B-AWARD and O the O Shenzhen B-ORG Science I-ORG and I-ORG Technology I-ORG Program O JCYJ20210324095007020 B-AWARD JCYJ20200109105201936 B-AWARD 20200803105052010 B-AWARD and O JCYJ20190808115605501 B-AWARD This O research O was O partly O funded O by O the O Science O and O Technology O of O Qinghai O Program O No. O 2015-HZ-812 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O U1607104 B-AWARD Amarout O II O Marie O Curie I-ORG Action I-ORG PCOFUND-GA-2011-291803 B-AWARD the O Thousand O Talents O Plan O of O Qinghai O Province O of O China O 2017 O and O the O Ministry B-ORG of I-ORG Industry I-ORG and I-ORG Information I-ORG Technology I-ORG of I-ORG China I-ORG No. O P173008047 B-AWARD YZ O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81802761 O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shandong I-ORG Province I-ORG 2019GSF107014 O Postdoctoral B-ORG Research I-ORG Foundation I-ORG of I-ORG China I-ORG 2019M652405 O YW O was O funded O by O Academic B-ORG promotion I-ORG programme I-ORG of I-ORG Shandong I-ORG First I-ORG Medical I-ORG University I-ORG 2019QL024 O This O work O was O supported O by O grant O from O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG number O 81370383 B-AWARD and I-AWARD 81601231 O and O Yunnan O Province O Grant O number O 2013FB098 O Dr. O J. O Miller O Dr. O B. O Zhang O and O Ms O Roos O are O supported O by O the O National B-ORG Institutes I-ORG of I-ORG Health I-ORG HL111121 O and I-AWARD AG053832 O Dr O Guo O is O supported O by O China B-ORG Scholarship I-ORG Council I-ORG number O 201407820113 B-AWARD This O work O was O supported O by O National B-ORG Institutes I-ORG of I-ORG Health O USA O grant O R01CA160688 B-AWARD as O well O as O Edward O K. O Duch O Foundation O to O K.T O Grant-in-Aid O for O Scientific B-ORG Research I-ORG Grant O Numbers O 19H03714 B-AWARD and O 18K19576 B-AWARD to O M.N O and O National B-ORG Cancer I-ORG Institute O USA O cancer O center O support O grant O P30-CA016056 B-AWARD to O Roswell O Park O Comprehensive O Cancer O Center O RPCCC O This O study O was O funded O by O the O Key B-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Shaanxi I-ORG Program O No. O 2019SF-100 B-AWARD The B-ORG Bureau I-ORG of I-ORG Xi’an I-ORG Science I-ORG and I-ORG Technology I-ORG Program O No. O 201805098YX6SF32(1 B-AWARD The B-ORG Clinical I-ORG Research I-ORG Project I-ORG of I-ORG the I-ORG First I-ORG Affiliated I-ORG Hospital I-ORG of I-ORG Xi’an I-ORG Jiaotong I-ORG University I-ORG Program O No. O XJTU1AF-CRF-2019-023 B-AWARD The O funders O did O not O participate O in O the O design O data O analysis O and O writing O manuscript O of O the O study O except O for O providing O financial O support O This O work O was O financially O supported O by O following O funds O the O Central B-ORG Guidance I-ORG of I-ORG Local I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG Fund I-ORG Grant O No. O 2018CT5008 B-AWARD the O Project B-ORG of I-ORG Scientific I-ORG Research I-ORG of I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG in I-ORG Hunan I-ORG Grant O No. O 201809 B-AWARD The O Hunan B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O No. O 2019JJ50320/2018JJ3296 B-AWARD the O Clinical B-ORG Research I-ORG Center I-ORG for I-ORG Anesthesiology I-ORG of I-ORG ERAS I-ORG in I-ORG Hunan I-ORG Province I-ORG No. O 2018SK7001 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O National B-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 32171223 B-AWARD the O Guangdong B-ORG Natural I-ORG Science I-ORG Foundation I-ORG No. O 2021A1515010557 B-AWARD the O Shenzhen B-ORG Fundamental I-ORG Research I-ORG Program I-ORG No. O JCYJ20200109105836705 B-AWARD and O the O Shenzhen-Hong B-ORG Kong I-ORG Institute I-ORG of I-ORG Brain I-ORG Science-Shenzhen I-ORG Fundamental I-ORG Research I-ORG Institutions I-ORG No. O 2022SHIBS0003 B-AWARD This O research O was O funded O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG Grant O No. O 2017YFA0104703 B-AWARD the O 973 O National O Key O Basic O Research O Program O Grant O No. O 2014CB542203 B-AWARD the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG Grant O No. O BK20161285 B-AWARD the O Jiangsu O Provincial O Key O Medical O Center O the O Jiangsu O Students’ O innovation O and O entrepreneurship O training O program O Grant O No. O 201810304096X O and O the O Priority B-ORG Academic I-ORG Program I-ORG Development I-ORG of I-ORG Jiangsu I-ORG Higher I-ORG Education I-ORG Institutions I-ORG PAPD O This O work O was O supported O by O grants O from O the B-ORG Key I-ORG project I-ORG of I-ORG Natural I-ORG Sciences I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG 2015CFA078 O the O Yellow O Crane O Talent O Plan O Foundation O Research B-ORG Fund I-ORG of I-ORG Hubei I-ORG Province I-ORG Public I-ORG Health I-ORG Bureau I-ORG WJ2015MB144 O and O Research B-ORG Fund I-ORG of I-ORG Wuhan I-ORG Public I-ORG Health I-ORG Bureau I-ORG WX15A12 O The O study O sponsor O did O not O take O any O role O in O the O design O of O the O study O design O collection O analysis O interpretation O of O data O and O in O the O writing O of O the O manuscript O This O manuscript O was O supported O by O Program B-ORG for I-ORG New I-ORG Century I-ORG Excellent I-ORG Talents I-ORG in I-ORG University O Ministry B-AWARD of I-AWARD Education I-AWARD of I-AWARD China I-AWARD NCET-12-0661 O National B-ORG Natural I-ORG Science I-ORG foundation I-ORG of I-ORG China I-ORG 31370918 O Program B-ORG for I-ORG High I-ORG level I-ORG innovative I-ORG talents I-ORG in I-ORG Guizhou I-ORG Province I-ORG QKH-RC-2016-4031 O Program B-ORG for I-ORG Excellent I-ORG Young I-ORG Talents I-ORG of I-ORG Zunyi I-ORG Medical I-ORG University I-ORG 15ZY-001 O and O Project B-ORG of I-ORG Guizhou I-ORG Provincial I-ORG Department I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 2009C491 O This O study O was O supported O by O grants O from O the B-ORG Zhejiang I-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG LY14H160003 O the B-ORG Scientific I-ORG Innovation I-ORG Team I-ORG Project I-ORG of I-ORG Ningbo I-ORG 2012B82019 O the B-ORG Ningbo I-ORG Social I-ORG Developmental I-ORG Key I-ORG Research I-ORG Project I-ORG 2012C5015 B-AWARD the B-ORG Ningbo I-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2012A610208 O and I-AWARD 2012A610217 O and O the B-ORG Medical I-ORG and I-ORG Health I-ORG Research I-ORG Project I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2012ZDA042 O and I-AWARD 2014PYA017 O This O research O was O supported O by O the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 71661167005 O and O the B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG Sichuan I-ORG Province I-ORG No. O 2018SZ0114 I-AWARD No. I-AWARD 2019YFS0271 O which O provide O financial O support O in O the O design O of O study O and O analysis O of O data O and O the B-ORG 1·3·5 I-ORG Project I-ORG for I-ORG Disciplines I-ORG of I-ORG Excellence–Clinical I-ORG Research I-ORG Incubation I-ORG Project I-ORG West I-ORG China I-ORG Hospital I-ORG Sichuan I-ORG University I-ORG Grant O No. I-AWARD 2018HXFH023 I-AWARD ZYJC18013 O which O provide O financial O support O in O interpretation O of O data O and O writing O the O manuscript O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Nos O 81770527 B-AWARD to O Hui O Yin O and O 81401150 B-AWARD to O Hanfang O Mei O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2016A030313726 B-AWARD to O Hui O Yin O and O the O Special B-ORG Foundation I-ORG of I-ORG Public I-ORG Welfare I-ORG Research I-ORG and I-ORG Capacity I-ORG Building I-ORG of I-ORG Guangdong I-ORG Province I-ORG No. O 2017A020214020 B-AWARD to O Hui O Yin O This O study O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81271866 B-AWARD 81572012 B-AWARD the O Guangdong B-ORG Province I-ORG Universities I-ORG and I-ORG Colleges I-ORG Pearl I-ORG River I-ORG Scholar I-ORG Funded I-ORG Scheme I-ORG 2014 O the O Guangdong B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG Key I-ORG Project I-ORG 2016A030311025 O and O the O Guangzhou B-ORG health I-ORG and I-ORG medical I-ORG collaborative I-ORG innovation I-ORG major I-ORG special I-ORG project I-ORG 201604020011 O to O HJP O Funding O support O for O this O project O was O provided O in O part O by O the O Coordenação B-ORG de I-ORG Aperfeiçoamento I-ORG de I-ORG Pessoal I-ORG de I-ORG Nível I-ORG Superior—Brasil O CAPES)—Finance O Code O 001 O by O the O Fundação B-ORG de I-ORG Amparo I-ORG à I-ORG Pesquisa I-ORG do I-ORG Estado I-ORG do I-ORG Rio I-ORG Grande I-ORG do I-ORG Sul-FAPERGS O Grant O 21/2551-0001966-2 B-AWARD Brazil O and O by O the O Conselho B-ORG Nacional I-ORG de I-ORG Desenvolvimento I-ORG Científico I-ORG e I-ORG Tecnológico-CNPq O process O 406098/2018-2 B-AWARD CAPES/Programa O de O Excelência O Acadêmica O PROEX O process O 23038.002125/2021-85 O Grant O 0036/2021 O SMO O is O recipient O of O fellowship O from O CNPq O process O 304985/2020-1 O IB O and O GB O are O recipients O of O fellowship O from O CAPES/PROEX O processes O 88882.182148/2018-01 B-AWARD and O 88887.568915/2020-00 B-AWARD respectively O This O study O was O funded O by O the O Air B-ORG Force I-ORG Office I-ORG of I-ORG Scientific I-ORG Research I-ORG grant O no. O FA8655-12-2112 B-AWARD and O the O Biotechnology B-ORG and I-ORG Biological I-ORG Sciences I-ORG Research I-ORG Council I-ORG grant O no. O BB/J014400/1 B-AWARD J.C.P O was O funded O by O the O Australian B-ORG Research I-ORG Council I-ORG Discovery O Project O Grant O DP160102658 B-AWARD The O study O was O financially O supported O by O the O Ministry B-ORG of I-ORG Education I-ORG Youth I-ORG and I-ORG Sports I-ORG of I-ORG the I-ORG Czech I-ORG Republic I-ORG – I-ORG projects I-ORG “CENAKVA” I-ORG No. O CZ.1.05/2.1.00/01.0024 B-AWARD “CENAKVA B-ORG Center I-ORG Development” I-ORG No. O CZ.1.05/2.1.00/19.0380 B-AWARD and O “CENAKVA B-ORG II” I-ORG No. O LO1205 B-AWARD under I-AWARD the I-AWARD NPU I-AWARD I I-AWARD program O and O by O the O Grant B-ORG Agency I-ORG of I-ORG the I-ORG University I-ORG of I-ORG South I-ORG Bohemia I-ORG in I-ORG Ceske I-ORG Budejovice I-ORG GAJU060/2016/Z O and O NAZV B-ORG project I-ORG QJ1510119 B-AWARD QK1810296 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O GDAS’ B-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG 2019GDASYL-0302007 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31471966 O the O Guangdong B-ORG Natural I-ORG Science I-ORG Foundation I-ORG 2015A030313903 O and I-AWARD 2018A0303130197 O and O the O GDAS B-ORG Special I-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Development I-ORG 2017GDASCX-0107 O and I-AWARD 2018GDASCX-0107 O and O the O Talent B-ORG Project I-ORG of I-ORG Guangdong I-ORG Academy I-ORG of I-ORG Sciences I-ORG 2018GDASCX-0932 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O research O was O funded O by O National B-ORG University I-ORG of I-ORG Singapore I-ORG R-180-000-016-733 O NRF-CRP7-2010-02 B-AWARD Huazhong B-ORG University I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG 513-3004513113 O and O the B-ORG Chinese I-ORG Academy I-ORG of I-ORG Sciences I-ORG KJZD-EW-G20-01 O This O study O was O supported O by O grants O from O the O National B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O No. O 31770985 B-AWARD the O Social B-ORG Development I-ORG Project I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O BE2019665 B-AWARD the O Postdoctoral B-ORG Science I-ORG Foundation I-ORG Grant I-ORG of I-ORG China I-ORG No. O 2016M591913 B-AWARD the O Jiangsu B-ORG Provincial I-ORG Medical I-ORG Youth I-ORG Talent I-ORG No. O QNRC2016732 B-AWARD the O Jiangsu B-ORG Provincial I-ORG “Six I-ORG Peaks I-ORG Talent” I-ORG Program I-ORG No. O 2016-WSW-043 B-AWARD the O Suzhou B-ORG Municipal I-ORG Project I-ORG of I-ORG Gusu I-ORG Health I-ORG Talent I-ORG Young I-ORG Top I-ORG Talent I-ORG No. O 2018-057 B-AWARD the O Gusu B-ORG Health I-ORG Talents I-ORG Cultivation I-ORG Program I-ORG No. O GSWS2019028 B-AWARD the O Scientific B-ORG Research I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Provincial I-ORG “333 I-ORG Projects” I-ORG No. O BRA2019327 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Suzhou I-ORG City I-ORG China I-ORG Nos O SYS2019053 B-AWARD and I-AWARD SLC201906 O the O Provincial B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG Jiangsu I-ORG Province I-ORG No. O BK20161225 B-AWARD and O the O Scientific B-ORG Research I-ORG Program I-ORG of I-ORG Jiangsu I-ORG Provincial I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG No. O H201620 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O the O US O National B-ORG Institutes I-ORG of I-ORG Health I-ORG Grant O 1R15GM104833-01 B-AWARD the O US O National B-ORG Science I-ORG Foundation I-ORG Grants O DBI B-AWARD 1624654 I-AWARD and O MCB B-AWARD 1714778 O and O the O Kennesaw B-ORG State I-ORG University I-ORG Foundation O Foundation O Fellow I-AWARD in I-AWARD Biochemistry O This O work O was O supported O byNational O Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG ChinaGrant O numbers30871436,30973297and31171194,National O Basic I-ORG Research I-ORG Program(973 O of O China O Grant O numbers2010CB945002and2014CB541703,Shandong O Provincial I-ORG Science I-ORG and I-ORG Technology I-ORG Key I-ORG ProgramGrant O number2009GG10002039,Shandong O Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG ChinaGrant O numberZR2013CQ041andIndependent O Innovation I-ORG Foundation I-ORG of I-ORG Shandong I-ORG UniversityGrant O number2013GN011 O Funding O to O pay O the O Open O Access O publication O charges O for O this O article O was O provided O by O the O National O Basic O Research O Program O 973 O of O China O Grant O number O 2014CB541703 O This O work O was O supported O by O grants O from O Shanghai B-ORG Municipal I-ORG Commission I-ORG of I-ORG Health I-ORG and I-ORG Family I-ORG Planning I-ORG Key O Program O No.2017ZZ02026 B-AWARD Developing O Plan O of O Important O Weak O Disciplines O No.2016ZB0103 B-AWARD and B-AWARD No.20164Y0095 O the B-ORG Fourth I-ORG Round I-ORG of I-ORG Three-Year I-ORG Public I-ORG Health I-ORG Action I-ORG Plan I-ORG 2015–2017 O GWIV-36 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81602870 O No. B-AWARD 81602868 O No. B-AWARD 81728017 O Shanghai O Science B-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG No.17411965300 O The O funders O had O no O role O in O the O study O design O data O collection O analysis O or O interpretation O of O data O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O financially O through O a O grant O from O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31801750 O Fruit B-ORG innovation I-ORG team I-ORG of I-ORG Shandong I-ORG modern I-ORG agricultural I-ORG industry I-ORG technology I-ORG system I-ORG No. O SDAIT-06-21 O and O Agricultural B-ORG scientific I-ORG and I-ORG technological I-ORG innovation I-ORG project I-ORG of I-ORG Shandong I-ORG Academy I-ORG of I-ORG Agricultural I-ORG Sciences I-ORG No. O CXGC2018E17 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O in O part O by O the O Guangdong B-ORG Medical I-ORG Research I-ORG Foundation I-ORG A2020232 O the O National B-ORG Key-area I-ORG Research I-ORG and I-ORG Development I-ORG Programme I-ORG of I-ORG China I-ORG No. O 2022YFC2504101 B-AWARD and O 2022YFC2504105 B-AWARD the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O U20A20399 B-AWARD and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG for I-ORG Young I-ORG Scientists I-ORG of I-ORG China I-ORG 82100181 O The O sponsors O were O not O involved O in O the O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O grants O of O Zhejiang B-ORG provincial I-ORG Science I-ORG and I-ORG technology I-ORG plan I-ORG No.2013C33248 O Zhejiang B-ORG Provincial I-ORG Traditional I-ORG Chinese I-ORG Medicine I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG No. O 2016ZA122 O Zhejiang B-ORG Provincial I-ORG Medical I-ORG and I-ORG Health I-ORG Science I-ORG and I-ORG Technology I-ORG Plan I-ORG No.2016KYA085 O This O study O was O supported O by O grants O from O the O Taipei B-ORG Tzu I-ORG Chi I-ORG Hospital I-ORG Buddhist I-ORG Tzu I-ORG Chi I-ORG Medical I-ORG Foundation I-ORG TCRD-TPE-103-RT-2 O TCRD-I103-01-01 B-AWARD TCRD-TPE-MOST-103-01 B-AWARD TCRD-TPE-MOST-104-09 B-AWARD TCRD-TPE-106-C1-1 B-AWARD TCRD-TPE-106-RT-3 B-AWARD grants O from O the O Tzu B-ORG Chi I-ORG University I-ORG Hualien I-ORG Taiwan I-ORG TCMMP104-06-03 O Grants O from O the O National B-ORG Science I-ORG Council I-ORG MOST O 104-2314-B-303-013-MY3 O to O Y. O L. O Ko, O and O grants O from O the O Taipei O Tzu O Chi O Hospital O Buddhist O Tzu O Chi O Medical O Foundation O TCRD-TPE-103-22 O TCRD-TPE-104-18 B-AWARD TCRD-TPE-106-46 B-AWARD TCRD-TPE-106-46(2/2 B-AWARD to O M. O S. O Teng O This O work O was O funded O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31671676 O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Project I-ORG of I-ORG China I-ORG 2016YFD0101802 O and O the O Israel B-ORG Science I-ORG Foundation I-ORG 1366/18 O This O research O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 51608175 O the O Key B-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG of I-ORG the I-ORG Education I-ORG Department I-ORG of I-ORG Henan I-ORG Province I-ORG No. O 17B610004 B-AWARD and O the B-ORG Doctor I-ORG Foundation I-ORG of I-ORG Henan I-ORG Institute I-ORG of I-ORG Engineering I-ORG Nos O D2015020 B-AWARD D2014021 B-AWARD The B-ORG Program I-ORG of I-ORG Guangxi I-ORG Zhuang I-ORG Autonomous I-ORG Region I-ORG Association I-ORG for I-ORG Science I-ORG and I-ORG Technology I-ORG for I-ORG Young I-ORG Teachers I-ORG and I-ORG Graduate I-ORG Students I-ORG in I-ORG 2016 I-ORG Item O number O gui B-AWARD ke I-AWARD xie〔2016〕Z-46 O The B-ORG Program I-ORG of I-ORG Humanities I-ORG and I-ORG Social I-ORG Science I-ORG Research I-ORG Center I-ORG of I-ORG Guangxi I-ORG Medical I-ORG University I-ORG for I-ORG Graduate I-ORG Students I-ORG in I-ORG 2016 I-ORG Item O number O 2016RWY06 B-AWARD Innovation B-ORG Project I-ORG of I-ORG Guangxi I-ORG Graduate I-ORG Education I-ORG in I-ORG 2017 I-ORG Item O number O YCSW2017114 B-AWARD This O work O was O supported O by O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 62104156 B-AWARD 62104157 B-AWARD 62074102 B-AWARD Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG 2022A1515010979 O 2023A1515011256 B-AWARD China O Science B-ORG and I-ORG Technology I-ORG plan I-ORG project I-ORG of I-ORG Shenzhen I-ORG SGDX20190919102801693 O 20220808165025003 B-AWARD 20200812000347001 B-AWARD China O This O work O was O supported O by O the O Agricultural B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG Program I-ORG of I-ORG China I-ORG ASTIP-IAS15 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31472180 O and O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG 2018M641566 O This O study O was O supported O by O VA B-ORG Merit I-ORG Award I-ORG 5 B-AWARD I01 I-AWARD BX005730 O Dr. O Zhou O is O a O VA B-ORG Research I-ORG Career I-ORG Scientist O IK6BX004477 O National B-ORG Institutes I-ORG of I-ORG Health I-ORG Grant O R01 B-AWARD DK104893 O R01DK-057543 B-AWARD and O R21 B-AWARD AA026629-01(to O H.Z O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NO. O 82204748 B-AWARD to O Y.W O Star B-ORG Program I-ORG of I-ORG Shanghai I-ORG Jiao I-ORG Tong I-ORG University O No. O YG2021QN54 B-AWARD to O J.Z O This O work O was O mainly O financed O by O the O Slovak B-ORG Research I-ORG and I-ORG Development I-ORG Agency I-ORG with O the O project O APVV-18-0420 B-AWARD and O by O the O VEGA B-ORG Agency I-ORG with O the O projects O 2/0082/22 B-AWARD and O 2/0137/23 B-AWARD This O study O has O been O also O supported O by O the O European B-ORG Regional I-ORG Development I-ORG Fund I-ORG project O 313011V578 B-AWARD This O work O was O financially O supported O by O grants O from O the O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2016YFA0500600 O and O 2018YFC0310600 B-AWARD the O Basic B-ORG Research I-ORG Project I-ORG of I-ORG Science I-ORG and I-ORG Technology I-ORG Commission I-ORG of I-ORG Shanghai I-ORG Municipality I-ORG 17JC1401800 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31970049 O 31670098 B-AWARD and O 31670097 B-AWARD This O research O was O supported O by O the O Civil O O Military O Technology O Cooperation O Program O through O the O National B-ORG Research I-ORG Foundation I-ORG of I-ORG Korea I-ORG NRF O funded O by O the O Ministry O of O Science O and O ICT O NO. O NRF-2014M3C1A9060874 B-AWARD by O the O Korea O Evaluation O Institute O of O Industrial O Technology O KEIT O funded O by O the O Ministry B-ORG of I-ORG Trade I-ORG Industry I-ORG and I-ORG Energy I-ORG MOTIE O NO. O 10074267 B-AWARD and O by O the O Samsung B-ORG Research O Funding O Center O of O Samsung O Electronics O under O SRFC-IT B-AWARD 1501-03 I-AWARD The O study O was O supported O by O grants O from O the O Ministry B-ORG of I-ORG Science I-ORG and I-ORG Technology O Taiwan O to O Y.-H.P O MOST O 109-2327-B-400-004 I-AWARD and O MOST B-AWARD 109-2320-B-010-034-MY3 O RJ.-M.L O MOST O 110-2320-B-030-008 I-AWARD and O MOST B-AWARD 111-2320-B-030-008 O and O C.-Y.F.H O MOST O 110-2320-B-A49A-541 O MOST111-2321-B-A49-007 B-AWARD and O MOST B-AWARD 111-2320-B-A49-036 O by O a O grant O from O the O National B-ORG Yang I-ORG Ming I-ORG Chiao I-ORG Tung I-ORG University—Far O Eastern O Memorial O Hospital O Joint O Research O Program O 111DN03 O to O Y.-H.P O and O by O grants O from O the O National B-ORG Science I-ORG and I-ORG Technology I-ORG Council I-ORG MOST O 111-2320-B-077-002-MY3 O to O H.-K.L O This O work O was O supported O by O the O National B-ORG Nature I-ORG Science I-ORG Foundation I-ORG of I-ORG China O No. B-AWARD 81702957 O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation O No. B-AWARD 2017M620230 O Postdoctoral B-ORG Research I-ORG Funding I-ORG Scheme I-ORG of I-ORG Jiangsu I-ORG Province I-ORG 2017 O No.1701197B B-AWARD and O the O Priority O Academic O Program O Development O PAPD O of O Jiangsu O Higher O Education O Institutions O This O work O was O supported O by O the B-ORG Special I-ORG Fund I-ORG for I-ORG Agro-scientific I-ORG Research I-ORG in I-ORG the I-ORG Public I-ORG Interest I-ORG No. O 201303028 B-AWARD the B-ORG National I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 31501643 B-AWARD 31571982 I-AWARD and I-AWARD 31571981 O and O the B-ORG Agriculture I-ORG Research I-ORG System I-ORG of I-ORG China I-ORG CARS-25-B-05 O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O partially O financially O supported O through O a O grant O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC81541140 O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hubei I-ORG Province I-ORG of O China O 2014CFB645 O and O the O Foundation B-ORG for I-ORG Innovative I-ORG Research I-ORG Team I-ORG of I-ORG Hubei I-ORG University I-ORG of I-ORG Medicine I-ORG 2014CXG05 O This O work O is O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 32000395 O to O J.L O and O 32070592 B-AWARD to O J.-X.Y O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2022A1515011873 O to O J.L O and O 2022A1515010717 B-AWARD to O J.-X.Y O the O Guangzhou B-ORG Municipal I-ORG Science I-ORG and I-ORG Technology I-ORG Bureau I-ORG 202102020938 O to O J.L O the O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG 2019A1515110762 O to O J.-X.Y O the O Guangdong B-ORG Pearl I-ORG River I-ORG Talents I-ORG Program I-ORG 2021QN02Y168 O to O J.L O 2019QN01Y183 B-AWARD to O J.-X.Y O the O Austrian B-ORG Science I-ORG Fund I-ORG FWF I-ORG P26713 O to O M.B O and O the O Fondation B-ORG pour I-ORG la I-ORG Recherche I-ORG Médicale I-ORG EQU202003010413 O to O G.L O This O work O was O supported O by O grants O from O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81700967 O to O Jianying O Zhang O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Hunan I-ORG Province I-ORG 2018JJ3706 O to O Jianying O Zhang O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province I-ORG 2017A030310595 O to O Chanchan O Chen O and O the O Science B-ORG and I-ORG Technology I-ORG Research I-ORG Foundation I-ORG of I-ORG Shenzhen I-ORG JCYJ20170303155435885 O to O Chanchan O Chen O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O research O funds O from O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG Guangdong I-ORG Province O China O No. O 2018B030311042 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Guangdong I-ORG Province O China O No. O 2017A020215183 B-AWARD the B-ORG Major I-ORG Program I-ORG for I-ORG Health I-ORG Medical I-ORG Collaborative I-ORG Innovation I-ORG of I-ORG Guangzhou I-ORG China I-ORG No. O 201704020216 B-AWARD the B-ORG Frontier I-ORG Research I-ORG Program I-ORG of I-ORG Guangzhou I-ORG Regenerative I-ORG Medicine I-ORG and I-ORG Health I-ORG Guangdong I-ORG Laboratory I-ORG China I-ORG No. O 2018GZR110105014 B-AWARD and O the O Startup B-ORG Project I-ORG for I-ORG Clinical I-ORG Trials I-ORG of I-ORG Southern I-ORG Medical I-ORG University I-ORG China I-ORG No. O LC2016ZD027 B-AWARD The O current O work O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 81770566 B-AWARD the O New B-ORG Medical I-ORG Technology I-ORG Foundation I-ORG of I-ORG West I-ORG China I-ORG Hospital I-ORG of I-ORG Sichuan I-ORG University I-ORG No. O XJS2016004 B-AWARD and O the O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Sichuan I-ORG Science I-ORG and I-ORG Technology I-ORG Department I-ORG No. O 2019YFS0029 B-AWARD The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O study O was O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O No. B-AWARD 81470170 O the O Research B-ORG Committee I-ORG of I-ORG the I-ORG University I-ORG of I-ORG Macau I-ORG SRG2015-00060-ICMS-QRCM O MYRG2017-00178-ICMS B-AWARD and O CPG2014-00012-ICMS B-AWARD the O Guangzhou B-ORG Science I-ORG and I-ORG Technology I-ORG Innovation I-ORG funding I-ORG EF007/ICMS-YH/2018/GSTIC O the O Project O funded O by O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG No. O 2017M622811 O and O the O opening O fund O of O the O State O Key O Laboratory O of O Quality O Research O in O Chinese O Medicine O of O University O of O Macau O No. O SKL-QRCM-2014-2016 O This O work O was O supported O in O part O or O in O whole O by O the O Natural B-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31300777 O and O 31371091 B-AWARD the O Fundamental B-ORG Research I-ORG Funds I-ORG of I-ORG China I-ORG N120520001 O and O N120320001 B-AWARD and O the O Liaoning B-ORG Provincial I-ORG Talent I-ORG Support I-ORG Program I-ORG LJQ2013029 O This O work O was O supported O in O part O by O grants O from O the O Undergraduate B-ORG Innovation I-ORG and I-ORG Entrepreneurship I-ORG Training I-ORG Program I-ORG 201712121157 O the O China B-ORG Postdoctoral I-ORG Science I-ORG Foundation I-ORG CPSF O No. B-AWARD 2018T110855 I-AWARD and I-AWARD No. I-AWARD 2017M622650 O and O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG NSFC O No. B-AWARD 81300370 O There O was O no O additional O external O funding O received O for O this O study O The O funders O had O no O role O in O study O design O data O collection O and O analysis O decision O to O publish O or O preparation O of O the O manuscript O This O work O was O supported O by O National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG 2018YFD0901103 O and O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China-Shandong I-ORG Joint I-ORG Fund I-ORG for I-ORG Marine I-ORG Science I-ORG Research I-ORG Centers I-ORG U1606403 O and O the B-ORG Fundamental I-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG No. O 201762028 O The O work O was O supported O by O the O National B-ORG Key I-ORG Research I-ORG and I-ORG Development I-ORG Program I-ORG of I-ORG China I-ORG 2016YFC1000703 O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 81300532 O Zhejiang B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG LQ17H040001 O and O the O Medical B-ORG Scientific I-ORG Research I-ORG Foundation I-ORG of I-ORG Zhejiang I-ORG Province I-ORG 2016KYA120 O and O 2017KY427 O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG 31601469 O Science B-ORG and I-ORG Technology I-ORG Program I-ORG of I-ORG Guangzhou I-ORG 201604020089 O Grant B-ORG Scheme I-ORG for I-ORG the I-ORG Cultivation I-ORG of I-ORG Postgraduate I-ORG Innovative I-ORG Ability I-ORG in I-ORG Guangzhou I-ORG University I-ORG 2018GDJC-M05 O The O funding O body O not O involved O in O the O design O of O the O study O and O collection O analysis O and O interpretation O of O data O and O in O writing O the O manuscript O The O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG Grant O no. O 31572409 B-AWARD the O National B-ORG Basic I-ORG Research I-ORG Program I-ORG of I-ORG China I-ORG Grant O no. O 2013CB127304 B-AWARD and O Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG Grant O no. O 2662015JC002 B-AWARD provided O the O funds O for O the O realization O of O this O project O The O Melbourne O InFANT O Program O was O funded O by O a O National B-ORG Health I-ORG and I-ORG Research I-ORG Council I-ORG Project I-ORG Grant I-ORG APP1008879 O JH O is O supported O by O Canadian B-ORG Institutes I-ORG for I-ORG Health I-ORG Research I-ORG New I-ORG Investigator I-ORG Award I-ORG #34004 O KDH O is O supported O by O an O Australian B-ORG Research I-ORG Council I-ORG Future I-ORG Fellowship I-ORG FT130100637 O O Honorary B-ORG National I-ORG Heart I-ORG Foundation I-ORG of I-ORG Australia I-ORG Future I-ORG Leader I-ORG Fellowship I-ORG 100370 O KLD O is O supported O by O a O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG Postgraduate I-ORG Scholarship I-ORG GNT1092876 O during O analyses O for O this O paper O and O is O currently O supported O by O a O National B-ORG Health I-ORG and I-ORG Medical I-ORG Research I-ORG Council I-ORG Centre I-ORG of I-ORG Research I-ORG Excellence I-ORG APP1057608 O This O work O was O funded O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O numbers O 61904127 B-AWARD 62274122 B-AWARD and O 62004144 B-AWARD Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG grant O number O 2021A1515010651 B-AWARD National B-ORG Key I-ORG R&D I-ORG Program I-ORG of I-ORG China I-ORG grant O number O 2022YFB3207100 B-AWARD Fundamental B-ORG Research I-ORG Funds I-ORG for I-ORG the I-ORG Central I-ORG Universities I-ORG grant O numbers O 202401002 B-AWARD 203134004 B-AWARD 20212VA100 B-AWARD and O 2021VB006 B-AWARD and O Hubei B-ORG Provincial I-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG grant O number O 2020CFA032 B-AWARD This O research O was O funded O by O the O Third B-ORG Institute I-ORG of I-ORG Oceanography I-ORG Ministry I-ORG of I-ORG Natural I-ORG Resources I-ORG China O grant O number O IF004-2022 B-AWARD Financial O support O for O the O lead O author O K.-H.L O was O provided O by O the O WWF-Malaysia B-ORG grant O numbers O PV049-2019 B-AWARD and O PV023-2022 B-AWARD funding O for O renting O the O facility O instruments O for O the O molecular O analyses O was O provided O The O APC O was O funded O by O the O China-ASEAN B-ORG Maritime I-ORG Cooperation I-ORG fund O projects O “Marine O Protected O Areas O Network O in O China-ASEAN O Countries” O and O “Monitoring O and O Conservation O of O the O coastal O ecosystem O in O the O South O China O Sea” O National O Natural O Science O foundation O of O China O No: O 41961144022 B-AWARD Field O sampling O was O supported O by O Universiti B-ORG Malaya I-ORG grants O BK018-2015 B-AWARD RP018C-16SUSC B-AWARD and O IF030B-2019 B-AWARD This O research O was O financially O supported O by O the O National B-ORG Natural I-ORG Science I-ORG Foundation I-ORG of I-ORG China I-ORG No. O 52275575 B-AWARD the O Science B-ORG and I-ORG Technology I-ORG Planning I-ORG Project I-ORG of I-ORG Fujian I-ORG Province I-ORG No. O 2020H6003 B-AWARD 2022H6036 B-AWARD 2021J011196 B-AWARD and O the O Guangdong B-ORG Basic I-ORG and I-ORG Applied I-ORG Basic I-ORG Research I-ORG Foundation I-ORG No. O 2022A1515010923 B-AWARD 2022A1515010949 B-AWARD