text: Ventral and dorsal striatal dopamine efflux and behavior in rats with simple vs. co-morbid histories of cocaine sensitization and neonatal ventral hippocampal lesions.
  UNLABELLED:
  RATIONAL: Exposing animal models of mental illness to addictive drugs provides an approach to understanding the neural etiology of dual diagnosis disorders. Previous studies have shown that neonatal ventral hippocampal lesions (NVHL) in rats produce features of both schizophrenia and addiction vulnerability.
  OBJECTIVE:
  This study investigated ventral and dorsal striatal dopamine (DA) efflux in NVHL rats combined with behavioral sensitization to cocaine.
  METHODS:
  Adult NVHL vs. SHAM-operated rats underwent a 5-day injection series of cocaine (15 mg/kg/day) vs. saline. One week later, rats were cannulated in nucleus accumbens SHELL, CORE, or caudate-putamen. Another week later, in vivo microdialysis sampled DA during locomotor testing in which a single cocaine injection (15 mg/kg) was delivered.
  RESULTS:
  NVHLs and cocaine history significantly increased behavioral activation approximately 2-fold over SHAM-saline history rats. DA efflux curves corresponded time dependently with the cocaine injection and locomotor curves and varied significantly by striatal region: Baseline DA levels increased 5-fold while cocaine-stimulated DA efflux decreased by half across a ventral to dorsal striatal gradient. However, NVHLs, prior cocaine history, and individual differences in behavior were not underpinned by differential DA efflux overall or within any striatal region.
  CONCLUSION:
  Differences in ventral/dorsal striatal DA efflux are not present in and are not required for producing differential levels of acute cocaine-induced behavioral activation in NVHLs with and without a behaviorally sensitizing cocaine history. These findings suggest other neurotransmitter systems, and alterations in striatal network function post-synaptic to DA transmission are more important to understanding the interactive effects of addictive drugs and mental illness.
  
entities.text: ['Ventral']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-20631994_T1
entities.text: ['dorsal striatal']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-20631994_T2
entities.text: ['neonatal ventral hippocampal lesions']
entities.type: Pathological_formation
entities.entity_id: PMID-20631994_T3
entities.text: ['neonatal ventral hippocampal lesions']
entities.type: Pathological_formation
entities.entity_id: PMID-20631994_T4
entities.text: ['NVHL']
entities.type: Pathological_formation
entities.entity_id: PMID-20631994_T5
entities.text: ['NVHL']
entities.type: Pathological_formation
entities.entity_id: PMID-20631994_T6
entities.text: ['NVHL']
entities.type: Pathological_formation
entities.entity_id: PMID-20631994_T7
entities.text: ['nucleus accumbens']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-20631994_T8
entities.text: ['caudate-putamen']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-20631994_T9
entities.text: ['NVHLs']
entities.type: Pathological_formation
entities.entity_id: PMID-20631994_T10
entities.text: ['striatal region']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-20631994_T11
entities.text: ['NVHLs']
entities.type: Pathological_formation
entities.entity_id: PMID-20631994_T12
entities.text: ['striatal region']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-20631994_T13
entities.text: ['ventral']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-20631994_T14
entities.text: ['dorsal striatal']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-20631994_T15
entities.text: ['striatal']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-20631994_T16
entities.text: ['ventral']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-20631994_T17
entities.text: ['dorsal striatal']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-20631994_T18
entities.text: ['ventral']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-20631994_T19
entities.text: ['dorsal striatal']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-20631994_T20
entities.text: ['neural']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-20631994_T21
entities.text: ['NVHLs']
entities.type: Pathological_formation
entities.entity_id: PMID-20631994_T22