text: Further Characterization of Activin A-induced IgA Response in Murine B Lymphocytes.
  We have recently shown that activin A, a member of TGF-beta superfamily, stimulates mouse B cells to express IgA isotype but other isotypes. In the present study, we further characterized effects of activin A on B cell growth and IgA expression. We found that activin A did not have effect on LPS-stimulated cell viability. In parallel, CFSE staining analysis revealed that activin A did not alter cell division. An increase of IgA secretion by activin A was completely abrogated by anti-activin A Ab but not by anti-TGFbeta1 Ab. In the same conditions, no other isotypes are significantly affected by each antibody treatment. Finally, activin A, as similar to TGF-beta1, increased IgA secretion by mesenteric lymph node cells. These results suggest that activin A can specifically stimulate IgA response, independent of TGF-beta in the gut.
  
entities.text: ['B Lymphocytes']
entities.type: Cell
entities.entity_id: PMID-20157600_T1
entities.text: ['B cells']
entities.type: Cell
entities.entity_id: PMID-20157600_T2
entities.text: ['B cell']
entities.type: Cell
entities.entity_id: PMID-20157600_T3
entities.text: ['cell']
entities.type: Cell
entities.entity_id: PMID-20157600_T4
entities.text: ['cell']
entities.type: Cell
entities.entity_id: PMID-20157600_T5
entities.text: ['lymph node cells']
entities.type: Cell
entities.entity_id: PMID-20157600_T6
entities.text: ['gut']
entities.type: Organism_subdivision
entities.entity_id: PMID-20157600_T7