text: [Quantitative analysis of regional cerebral blood flow in elderly with white matter lesions].
  OBJECTIVE:
  To observe whether the severity of white matter lesions (WML) is related to ischemia in elderly.
  METHODS:
  WML were divided into 2 categories (centrum semiovale and periventricular regions) and four grades (grade 0, grade 1, grade 2 and grade 3) according to the severity of WML showing on the FLAIR sequence of MRI using modified Fazekas scale. The values of regional cerebral blood flow (rCBF) within WML and other brain regions were measured using Xenon contrast CT.
  RESULTS:
  Mean rCBF (ml x 100 g(-1) x min(-1)) within lesions around periventricular areas, in right and left centrum semiovale were 20.8 +/- 2.8, 22.3 +/- 1.9 and 22.2 +/- 2.1 in grade 0; 20.3 +/- 2.5, 21.3 +/- 1.0 and 21.0 +/- 1.8 in grade1; 16.3 +/- 2.0, 15.6 +/- 1.7 and 15.9 +/- 0.9 in grade 2; 14.1 +/- 2.6, 14.5 +/- 2.2 and 14.2 +/- 1.9 in grade 3 respectively. The severity of WML is associated significantly with reduction of rCBF within lesions both in centrum semiovale and periventricular regions (all P < 0.05). There was no significant difference in rCBF values between grade 0 and 1, but significant differences existed between grade 0 and grades 2 and 3, between grade 1 and grades 2 and 3 (all P < 0.05). Statistical significance also existed between the severity of white matter lesions and rCBF in bilateral temporal lobes and lentiform nucleases (P < 0.05).
  CONCLUSIONS:
  The severity of WML both in centrum semiovale and periventricular regions is associated significantly with reduction of rCBF within lesions.
  
entities.text: ['blood']
entities.type: Organism_substance
entities.entity_id: PMID-19595081_T1
entities.text: ['white matter lesions']
entities.type: Pathological_formation
entities.entity_id: PMID-19595081_T2
entities.text: ['WML']
entities.type: Pathological_formation
entities.entity_id: PMID-19595081_T3
entities.text: ['WML']
entities.type: Pathological_formation
entities.entity_id: PMID-19595081_T4
entities.text: ['centrum semiovale']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-19595081_T5
entities.text: ['periventricular regions']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-19595081_T6
entities.text: ['WML']
entities.type: Pathological_formation
entities.entity_id: PMID-19595081_T7
entities.text: ['blood']
entities.type: Organism_substance
entities.entity_id: PMID-19595081_T8
entities.text: ['WML']
entities.type: Pathological_formation
entities.entity_id: PMID-19595081_T9
entities.text: ['brain']
entities.type: Organ
entities.entity_id: PMID-19595081_T10
entities.text: ['lesions']
entities.type: Pathological_formation
entities.entity_id: PMID-19595081_T11
entities.text: ['periventricular areas']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-19595081_T12
entities.text: ['centrum semiovale']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-19595081_T13
entities.text: ['WML']
entities.type: Pathological_formation
entities.entity_id: PMID-19595081_T14
entities.text: ['lesions']
entities.type: Pathological_formation
entities.entity_id: PMID-19595081_T15
entities.text: ['centrum semiovale']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-19595081_T16
entities.text: ['periventricular regions']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-19595081_T17
entities.text: ['white matter lesions']
entities.type: Pathological_formation
entities.entity_id: PMID-19595081_T18
entities.text: ['WML']
entities.type: Pathological_formation
entities.entity_id: PMID-19595081_T19
entities.text: ['centrum semiovale']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-19595081_T20
entities.text: ['periventricular regions']
entities.type: Pathological_formation
entities.entity_id: PMID-19595081_T21
entities.text: ['lesions']
entities.type: Pathological_formation
entities.entity_id: PMID-19595081_T22
entities.text: ['white matter lesions']
entities.type: Pathological_formation
entities.entity_id: PMID-19595081_T23
entities.text: ['cerebral']
entities.type: Organ
entities.entity_id: PMID-19595081_T24
entities.text: ['cerebral']
entities.type: Organ
entities.entity_id: PMID-19595081_T25
entities.text: ['temporal lobes']
entities.type: Multi-tissue_structure
entities.entity_id: PMID-19595081_T26