abstract: The aim of this study was to evaluate hemostatic variables in @entity0 according to different body mass index (BMI) values, and then correlate them with some metabolic parameters - fasting insulin and @entity3 , total @entity2 , high-density lipoprotein (HDL)- @entity2 , low-density lipoprotein (LDL)- @entity2 and @entity4 . Eighty-four female @entity0 aged 18-39 years were recruited, and agreed to participate in the study. The study group was divided into three subgroups according to BMI: low BMI (BMI < 18.5 kg/m2; n = 43), normal-weight (control) (BMI 18.5-24.99 kg/m2; n = 21) and overweight/ @entity1 (BMI > 25 kg/m2; n = 20). BMI was calculated, and the following measurements were taken: International Normalized Ratio, antithrombin III, @entity8 ) activity, @entity8 -antigen, plasma fibrinogen level, factor VII, Plasminogen activator inhibitor (PAI)-1 activity and antigen and metabolic parameters: fasting insulin and @entity3 , total @entity2 , HDL- @entity2 , LDL- @entity2 and @entity4 . The results were statistically analyzed. In the low BMI group, a negative correlation between fasting insulin and @entity6 activity, and a positive correlation between fasting @entity3 and @entity6 antigen were observed. Also, a strong negative correlation between @entity6 activity and insulin/ @entity3 index was found. Plasma insulin levels were significantly lower in the low-BMI @entity0 than in the overweight/ @entity1 group (p < 0.001) and with no difference compared to the control group. We did not find any difference in fasting @entity3 level between all groups. HDL- @entity2 showed the highest levels in the normal BMI group and was significantly higher than in the low BMI and @entity1 groups (p < 0.05 and p < 0.01, respectively). @entity6 activity in the low BMI @entity0 revealed @entity7 in comparison to control and overweight/ @entity1 @entity0 (p < 0.001 and p < 0.05, respectively). Lower antigen levels were also shown as compared to both these groups (p < 0.001 and p < 0.001, respectively). Similar results were obtained with @entity8 antigen levels (p < 0.001 and p < 0.001, respectively). There were no differences in activity of @entity8 in all groups. Obese @entity0 showed significantly higher fibrinogen levels than other BMI groups (p < 0.001 and p < 0.001 respectively). Analysis of hemostatic variables in @entity0 with a low BMI testify to the impaired fibrinolysis in this group, also showing a strong correlation with @entity5 metabolism.
  