abstract: BACKGROUND: Laparoscopic cholecystectomy is the treatment of choice for symptomatic @entity6 . @entity2 , however, can prolong hospital stay and lead to increased morbidity. In the context of a multimodal approach to @entity4 , intraperitoneal local anesthetic administration optimizes @entity4 and facilitates early postoperative recovery, and it may be associated with a decreased risk of side effects. METHODS: A total of 71 @entity0 was randomized to receive either intraperitoneal analgesic ( @entity9 group) or not (controls). At the completion of cholecystectomy, 10 mL of @entity5 0.5% were infused intraperitoneally in the @entity9 group and 8 h postoperatively, whereas in the controls, 10 mL of 0.9% @entity3 were administered in the corresponding points of time. Differences in @entity1 scores between groups were the primary endpoints. Opioid consumption and adverse effects were the secondary endpoints. RESULTS: The 2 groups were homogenous in respect to age, sex, body mass index (BMI), and duration of operation. No conversion, complication, or mortality was recorded. The @entity9 group had a lesser visual analog scale score at rest and at movement compared with controls at all points of time measured. Moreover, @entity7 consumption in the recovery room was significantly greater in the control group, and the consumption of @entity8 and the percentage of the @entity0 that requested rescue @entity4 in the ward was significantly greater in the control group. Local analgesic intraperitoneal injection as well as @entity10 for postoperative @entity4 had no significant adverse effects. CONCLUSION: Our study showed that 2 separate doses of intraperitoneally administered @entity5 significantly decreased @entity2 and the need for opioids compared with placebo. This technique is simple, safe, and without adverse effects.
  