id
stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
split_0_train_2700 | split_0_train_2700 | [
{
"id": "split_0_train_2700_passage",
"type": "progene_text",
"text": [
"Furthermore , our results suggest that APLP1 does not undergo the same type of regulated processing as APP and APLP2 ."
],
"offsets": [
[
0,
118
]
]
}
]
| [
{
"id": "split_0_train_4243_entity",
"type": "progene_text",
"text": [
"APLP1"
],
"offsets": [
[
39,
44
]
],
"normalized": []
},
{
"id": "split_0_train_4244_entity",
"type": "progene_text",
"text": [
"APP"
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[
103,
106
]
],
"normalized": []
},
{
"id": "split_0_train_4245_entity",
"type": "progene_text",
"text": [
"APLP2"
],
"offsets": [
[
111,
116
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2701 | split_0_train_2701 | [
{
"id": "split_0_train_2701_passage",
"type": "progene_text",
"text": [
"Complete sequencing and expression of three complement components , C1r , C4 and C1 inhibitor , of the classical activation pathway of the complement system in rainbow trout Oncorhynchus mykiss ."
],
"offsets": [
[
0,
195
]
]
}
]
| [
{
"id": "split_0_train_4246_entity",
"type": "progene_text",
"text": [
"complement components"
],
"offsets": [
[
44,
65
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],
"normalized": []
},
{
"id": "split_0_train_4247_entity",
"type": "progene_text",
"text": [
"C1r"
],
"offsets": [
[
68,
71
]
],
"normalized": []
},
{
"id": "split_0_train_4248_entity",
"type": "progene_text",
"text": [
"C4"
],
"offsets": [
[
74,
76
]
],
"normalized": []
},
{
"id": "split_0_train_4249_entity",
"type": "progene_text",
"text": [
"C1 inhibitor"
],
"offsets": [
[
81,
93
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2702 | split_0_train_2702 | [
{
"id": "split_0_train_2702_passage",
"type": "progene_text",
"text": [
"Three complement components , C1r , C4 and C1 inhibitor , of the classical activation pathway have been fully sequenced and their expression investigated in rainbow trout ( Oncorhynchus mykiss ) ."
],
"offsets": [
[
0,
196
]
]
}
]
| [
{
"id": "split_0_train_4250_entity",
"type": "progene_text",
"text": [
"complement components"
],
"offsets": [
[
6,
27
]
],
"normalized": []
},
{
"id": "split_0_train_4251_entity",
"type": "progene_text",
"text": [
"C1r"
],
"offsets": [
[
30,
33
]
],
"normalized": []
},
{
"id": "split_0_train_4252_entity",
"type": "progene_text",
"text": [
"C4"
],
"offsets": [
[
36,
38
]
],
"normalized": []
},
{
"id": "split_0_train_4253_entity",
"type": "progene_text",
"text": [
"C1 inhibitor"
],
"offsets": [
[
43,
55
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2703 | split_0_train_2703 | [
{
"id": "split_0_train_2703_passage",
"type": "progene_text",
"text": [
"Trout C1r cDNA encodes a 707-amino-acid ( aa ) protein with a theoretical M ( r ) of 77,200 ."
],
"offsets": [
[
0,
93
]
]
}
]
| [
{
"id": "split_0_train_4254_entity",
"type": "progene_text",
"text": [
"C1r"
],
"offsets": [
[
6,
9
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2704 | split_0_train_2704 | [
{
"id": "split_0_train_2704_passage",
"type": "progene_text",
"text": [
"The trout translation shows highest homology with carp C1r / s , and lower , equal homologies to mammalian C1r and C1s , and MASPs from other vertebrate species ."
],
"offsets": [
[
0,
162
]
]
}
]
| [
{
"id": "split_0_train_4255_entity",
"type": "progene_text",
"text": [
"C1r / s"
],
"offsets": [
[
55,
62
]
],
"normalized": []
},
{
"id": "split_0_train_4256_entity",
"type": "progene_text",
"text": [
"C1r"
],
"offsets": [
[
107,
110
]
],
"normalized": []
},
{
"id": "split_0_train_4257_entity",
"type": "progene_text",
"text": [
"C1s"
],
"offsets": [
[
115,
118
]
],
"normalized": []
},
{
"id": "split_0_train_4258_entity",
"type": "progene_text",
"text": [
"MASPs"
],
"offsets": [
[
125,
130
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2705 | split_0_train_2705 | [
{
"id": "split_0_train_2705_passage",
"type": "progene_text",
"text": [
"However , phylogenetic analysis and structural features suggest that the trout sequence , together with the two carp sequences , are the orthologues of mammalian C1r ."
],
"offsets": [
[
0,
167
]
]
}
]
| [
{
"id": "split_0_train_4259_entity",
"type": "progene_text",
"text": [
"C1r"
],
"offsets": [
[
162,
165
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2706 | split_0_train_2706 | [
{
"id": "split_0_train_2706_passage",
"type": "progene_text",
"text": [
"The trout C4 cDNA encodes a 1,724-aa protein with a theoretical M(r) of 192,600 ."
],
"offsets": [
[
0,
81
]
]
}
]
| [
{
"id": "split_0_train_4260_entity",
"type": "progene_text",
"text": [
"C4"
],
"offsets": [
[
10,
12
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2707 | split_0_train_2707 | [
{
"id": "split_0_train_2707_passage",
"type": "progene_text",
"text": [
"The trout translation shows higher homologies to the carp C4B and medaka C4 , but lower homologies to C4 from other species and the carp C4A ."
],
"offsets": [
[
0,
142
]
]
}
]
| [
{
"id": "split_0_train_4261_entity",
"type": "progene_text",
"text": [
"C4B"
],
"offsets": [
[
58,
61
]
],
"normalized": []
},
{
"id": "split_0_train_4262_entity",
"type": "progene_text",
"text": [
"C4"
],
"offsets": [
[
73,
75
]
],
"normalized": []
},
{
"id": "split_0_train_4263_entity",
"type": "progene_text",
"text": [
"C4"
],
"offsets": [
[
102,
104
]
],
"normalized": []
},
{
"id": "split_0_train_4264_entity",
"type": "progene_text",
"text": [
"C4A"
],
"offsets": [
[
137,
140
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2708 | split_0_train_2708 | [
{
"id": "split_0_train_2708_passage",
"type": "progene_text",
"text": [
"It has a predicted signal peptide of 22 aa , a alpha - chain of 773 aa , a beta - chain of 635 aa and a lambda - chain of 288 aa ."
],
"offsets": [
[
0,
130
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2709 | split_0_train_2709 | [
{
"id": "split_0_train_2709_passage",
"type": "progene_text",
"text": [
"Trout C1 inhibitor cDNA encodes a 611 - aa protein with a theoretical M(r) of 68,700 ."
],
"offsets": [
[
0,
86
]
]
}
]
| [
{
"id": "split_0_train_4265_entity",
"type": "progene_text",
"text": [
"C1 inhibitor"
],
"offsets": [
[
6,
18
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2710 | split_0_train_2710 | [
{
"id": "split_0_train_2710_passage",
"type": "progene_text",
"text": [
"The trout translation has a C - terminal serpin domain with high homologies with mammalian counterparts ( ~37 % identities ) , and a longer N - terminus , with no significant homology to other serpins , which contains two Ig - like domains ."
],
"offsets": [
[
0,
241
]
]
}
]
| [
{
"id": "split_0_train_4266_entity",
"type": "progene_text",
"text": [
"serpin"
],
"offsets": [
[
41,
47
]
],
"normalized": []
},
{
"id": "split_0_train_4267_entity",
"type": "progene_text",
"text": [
"serpins"
],
"offsets": [
[
193,
200
]
],
"normalized": []
},
{
"id": "split_0_train_4268_entity",
"type": "progene_text",
"text": [
"Ig"
],
"offsets": [
[
222,
224
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2711 | split_0_train_2711 | [
{
"id": "split_0_train_2711_passage",
"type": "progene_text",
"text": [
"A molecule containing two Ig - like domains followed by a serpin domain , has also been found in an EST clone from another bony fish , the Japanese flounder ."
],
"offsets": [
[
0,
158
]
]
}
]
| [
{
"id": "split_0_train_4269_entity",
"type": "progene_text",
"text": [
"Ig"
],
"offsets": [
[
26,
28
]
],
"normalized": []
},
{
"id": "split_0_train_4270_entity",
"type": "progene_text",
"text": [
"serpin"
],
"offsets": [
[
58,
64
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2712 | split_0_train_2712 | [
{
"id": "split_0_train_2712_passage",
"type": "progene_text",
"text": [
"This suggests a unique structural feature of C1 inhibitor in fish ."
],
"offsets": [
[
0,
67
]
]
}
]
| [
{
"id": "split_0_train_4271_entity",
"type": "progene_text",
"text": [
"C1 inhibitor"
],
"offsets": [
[
45,
57
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2713 | split_0_train_2713 | [
{
"id": "split_0_train_2713_passage",
"type": "progene_text",
"text": [
"The functional significance of the Ig domains is discussed ."
],
"offsets": [
[
0,
60
]
]
}
]
| [
{
"id": "split_0_train_4272_entity",
"type": "progene_text",
"text": [
"Ig"
],
"offsets": [
[
35,
37
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2714 | split_0_train_2714 | [
{
"id": "split_0_train_2714_passage",
"type": "progene_text",
"text": [
"The liver is the major site of expression of the three trout complement components , C1r , C4 and C1 inhibitor , although their expression is also detectable in other tissues ."
],
"offsets": [
[
0,
176
]
]
}
]
| [
{
"id": "split_0_train_4273_entity",
"type": "progene_text",
"text": [
"complement components"
],
"offsets": [
[
61,
82
]
],
"normalized": []
},
{
"id": "split_0_train_4274_entity",
"type": "progene_text",
"text": [
"C1r"
],
"offsets": [
[
85,
88
]
],
"normalized": []
},
{
"id": "split_0_train_4275_entity",
"type": "progene_text",
"text": [
"C4"
],
"offsets": [
[
91,
93
]
],
"normalized": []
},
{
"id": "split_0_train_4276_entity",
"type": "progene_text",
"text": [
"C1 inhibitor"
],
"offsets": [
[
98,
110
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2715 | split_0_train_2715 | [
{
"id": "split_0_train_2715_passage",
"type": "progene_text",
"text": [
"The extra - hepatic expression of complement genes may be important for local protection and inflammatory responses ."
],
"offsets": [
[
0,
117
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2716 | split_0_train_2716 | [
{
"id": "split_0_train_2716_passage",
"type": "progene_text",
"text": [
"Low - level constitutive expression of the three components was also detectable in a trout monocyte / macrophage cell line RTS-11 , but only the expression of C4 could be upregulated by LPS ."
],
"offsets": [
[
0,
191
]
]
}
]
| [
{
"id": "split_0_train_4277_entity",
"type": "progene_text",
"text": [
"C4"
],
"offsets": [
[
159,
161
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2717 | split_0_train_2717 | [
{
"id": "split_0_train_2717_passage",
"type": "progene_text",
"text": [
"Functional characterization of the Escherichia coli K-12 yiaMNO transport protein genes ."
],
"offsets": [
[
0,
89
]
]
}
]
| [
{
"id": "split_0_train_4278_entity",
"type": "progene_text",
"text": [
"yiaMNO"
],
"offsets": [
[
57,
63
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2718 | split_0_train_2718 | [
{
"id": "split_0_train_2718_passage",
"type": "progene_text",
"text": [
"The yiaMNO genes of Escherichia coli K-12 encode a binding protein - dependent secondary , or tri - partite ATP - independent periplasmic ( TRAP ) , transporter ."
],
"offsets": [
[
0,
162
]
]
}
]
| [
{
"id": "split_0_train_4279_entity",
"type": "progene_text",
"text": [
"yiaMNO"
],
"offsets": [
[
4,
10
]
],
"normalized": []
},
{
"id": "split_0_train_4280_entity",
"type": "progene_text",
"text": [
"tri - partite ATP - independent periplasmic ( TRAP ) , transporter"
],
"offsets": [
[
94,
160
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2719 | split_0_train_2719 | [
{
"id": "split_0_train_2719_passage",
"type": "progene_text",
"text": [
"Since only a few members of this family have been functionally characterized to date , we aimed to identify the substrate for this transporter ."
],
"offsets": [
[
0,
144
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2720 | split_0_train_2720 | [
{
"id": "split_0_train_2720_passage",
"type": "progene_text",
"text": [
"Cells that constitutively express the yiaK-S gene cluster metabolized the rare pentose L-xylulose , while deletion of the yiaMNO transporter genes reduced L-xylulose metabolism ."
],
"offsets": [
[
0,
178
]
]
}
]
| [
{
"id": "split_0_train_4281_entity",
"type": "progene_text",
"text": [
"yiaK-S"
],
"offsets": [
[
38,
44
]
],
"normalized": []
},
{
"id": "split_0_train_4282_entity",
"type": "progene_text",
"text": [
"yiaMNO transporter"
],
"offsets": [
[
122,
140
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2721 | split_0_train_2721 | [
{
"id": "split_0_train_2721_passage",
"type": "progene_text",
"text": [
"The periplasmic substrate - binding protein YiaO was found to bind L-xylulose , and stimulated L-xylulose uptake by spheroplasts ."
],
"offsets": [
[
0,
130
]
]
}
]
| [
{
"id": "split_0_train_4283_entity",
"type": "progene_text",
"text": [
"YiaO"
],
"offsets": [
[
44,
48
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2722 | split_0_train_2722 | [
{
"id": "split_0_train_2722_passage",
"type": "progene_text",
"text": [
"These date indicate that the yiaMNO transporter mediates uptake of this rare pentose ."
],
"offsets": [
[
0,
86
]
]
}
]
| [
{
"id": "split_0_train_4284_entity",
"type": "progene_text",
"text": [
"yiaMNO transporter"
],
"offsets": [
[
29,
47
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2723 | split_0_train_2723 | [
{
"id": "split_0_train_2723_passage",
"type": "progene_text",
"text": [
"Glial activation and TNFR-I upregulation precedes motor dysfunction in the spinal cord of mnd mice ."
],
"offsets": [
[
0,
100
]
]
}
]
| [
{
"id": "split_0_train_4285_entity",
"type": "progene_text",
"text": [
"TNFR-I"
],
"offsets": [
[
21,
27
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2724 | split_0_train_2724 | [
{
"id": "split_0_train_2724_passage",
"type": "progene_text",
"text": [
"Mice homozygous for the spontaneous motor neuron degeneration mutation ( mnd ) show at the age of 8 months a marked impairment of the motor function and accumulation of lipofuscin granules in the cytoplasm of almost all neurons of the central nervous system.We previously reported a significant increase in GFAP protein levels in the lumbar spinal cord homogenates by western blot analysis and upregulation of TNF , a proinflammatory cytokine , in the motor neurons of lumbar spinal cord of mnd mice , already in a presymptomatic stage ( 4 months of age ) ."
],
"offsets": [
[
0,
557
]
]
}
]
| [
{
"id": "split_0_train_4286_entity",
"type": "progene_text",
"text": [
"GFAP"
],
"offsets": [
[
307,
311
]
],
"normalized": []
},
{
"id": "split_0_train_4287_entity",
"type": "progene_text",
"text": [
"TNF"
],
"offsets": [
[
410,
413
]
],
"normalized": []
},
{
"id": "split_0_train_4288_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
434,
442
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2725 | split_0_train_2725 | [
{
"id": "split_0_train_2725_passage",
"type": "progene_text",
"text": [
"In the present study , using immunohistochemical analysis , we performed a time course in mnd mice ( 1 , 4 and 9 months of age ) evaluating the expression and the distribution of astroglial and microglial cells and the expression of both TNF receptors , TNFR-I and TNFR-II ."
],
"offsets": [
[
0,
274
]
]
}
]
| [
{
"id": "split_0_train_4289_entity",
"type": "progene_text",
"text": [
"TNF receptors"
],
"offsets": [
[
238,
251
]
],
"normalized": []
},
{
"id": "split_0_train_4290_entity",
"type": "progene_text",
"text": [
"TNFR-I"
],
"offsets": [
[
254,
260
]
],
"normalized": []
},
{
"id": "split_0_train_4291_entity",
"type": "progene_text",
"text": [
"TNFR-II"
],
"offsets": [
[
265,
272
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2726 | split_0_train_2726 | [
{
"id": "split_0_train_2726_passage",
"type": "progene_text",
"text": [
"We observed a marked increase in astroglial and microglial cells and in TNFR-I immunoreactivity already at the 4th month ."
],
"offsets": [
[
0,
122
]
]
}
]
| [
{
"id": "split_0_train_4292_entity",
"type": "progene_text",
"text": [
"TNFR-I"
],
"offsets": [
[
72,
78
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2727 | split_0_train_2727 | [
{
"id": "split_0_train_2727_passage",
"type": "progene_text",
"text": [
"Since motor neuron dysfunction occurs in mnd mice in the absence of evident loss of spinal motor neurons , the present results indicate that the activation of microglial cells and astrocytes is independent from neuronal degeneration ."
],
"offsets": [
[
0,
234
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2728 | split_0_train_2728 | [
{
"id": "split_0_train_2728_passage",
"type": "progene_text",
"text": [
"The role of TNF and TNFR-I on motor neurons is still to be demonstrated ."
],
"offsets": [
[
0,
73
]
]
}
]
| [
{
"id": "split_0_train_4293_entity",
"type": "progene_text",
"text": [
"TNF"
],
"offsets": [
[
12,
15
]
],
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},
{
"id": "split_0_train_4294_entity",
"type": "progene_text",
"text": [
"TNFR-I"
],
"offsets": [
[
20,
26
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2729 | split_0_train_2729 | [
{
"id": "split_0_train_2729_passage",
"type": "progene_text",
"text": [
"Polyol pathway - dependent osmotic and oxidative stresses in aldose reductase - mediated apoptosis in human lens epithelial cells : role of AOP2 ."
],
"offsets": [
[
0,
146
]
]
}
]
| [
{
"id": "split_0_train_4295_entity",
"type": "progene_text",
"text": [
"aldose reductase"
],
"offsets": [
[
61,
77
]
],
"normalized": []
},
{
"id": "split_0_train_4296_entity",
"type": "progene_text",
"text": [
"AOP2"
],
"offsets": [
[
140,
144
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2730 | split_0_train_2730 | [
{
"id": "split_0_train_2730_passage",
"type": "progene_text",
"text": [
"Aldose reductase ( AR ) has been implicated as a major contributor to the pathogenesis of diabetic cataracts ."
],
"offsets": [
[
0,
110
]
]
}
]
| [
{
"id": "split_0_train_4297_entity",
"type": "progene_text",
"text": [
"Aldose reductase"
],
"offsets": [
[
0,
16
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],
"normalized": []
},
{
"id": "split_0_train_4298_entity",
"type": "progene_text",
"text": [
"AR"
],
"offsets": [
[
19,
21
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2731 | split_0_train_2731 | [
{
"id": "split_0_train_2731_passage",
"type": "progene_text",
"text": [
"AR activation generates osmotic and oxidative stresses via the polyol pathway and induces cell death signals ."
],
"offsets": [
[
0,
110
]
]
}
]
| [
{
"id": "split_0_train_4299_entity",
"type": "progene_text",
"text": [
"AR"
],
"offsets": [
[
0,
2
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2732 | split_0_train_2732 | [
{
"id": "split_0_train_2732_passage",
"type": "progene_text",
"text": [
"Antioxidant protein 2 ( AOP2 ) protects cells from oxidative stress ."
],
"offsets": [
[
0,
69
]
]
}
]
| [
{
"id": "split_0_train_4300_entity",
"type": "progene_text",
"text": [
"Antioxidant protein 2"
],
"offsets": [
[
0,
21
]
],
"normalized": []
},
{
"id": "split_0_train_4301_entity",
"type": "progene_text",
"text": [
"AOP2"
],
"offsets": [
[
24,
28
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2733 | split_0_train_2733 | [
{
"id": "split_0_train_2733_passage",
"type": "progene_text",
"text": [
"We investigated the effect of AR overexpression on polyol accumulation and on hyperglycemic oxidative stress and osmotic stress , as well as the effects of these stresses on human lens epithelial cell ( hLEC ) survival ."
],
"offsets": [
[
0,
220
]
]
}
]
| [
{
"id": "split_0_train_4302_entity",
"type": "progene_text",
"text": [
"AR"
],
"offsets": [
[
30,
32
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2734 | split_0_train_2734 | [
{
"id": "split_0_train_2734_passage",
"type": "progene_text",
"text": [
"hLECs overexpressing the AR became apoptotic during hyperglycemia and showed elevated levels of intracellular polyols ."
],
"offsets": [
[
0,
119
]
]
}
]
| [
{
"id": "split_0_train_4303_entity",
"type": "progene_text",
"text": [
"AR"
],
"offsets": [
[
25,
27
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2735 | split_0_train_2735 | [
{
"id": "split_0_train_2735_passage",
"type": "progene_text",
"text": [
"Glutathione and AOP2 levels were significantly decreased in these cells ."
],
"offsets": [
[
0,
73
]
]
}
]
| [
{
"id": "split_0_train_4304_entity",
"type": "progene_text",
"text": [
"AOP2"
],
"offsets": [
[
16,
20
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2736 | split_0_train_2736 | [
{
"id": "split_0_train_2736_passage",
"type": "progene_text",
"text": [
"Interestingly , supply of AOP2 and/or the AR inhibitor fidarestat protected the cells against hyperglycemia - induced death ."
],
"offsets": [
[
0,
125
]
]
}
]
| [
{
"id": "split_0_train_4305_entity",
"type": "progene_text",
"text": [
"AOP2"
],
"offsets": [
[
26,
30
]
],
"normalized": []
},
{
"id": "split_0_train_4306_entity",
"type": "progene_text",
"text": [
"AR"
],
"offsets": [
[
42,
44
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2737 | split_0_train_2737 | [
{
"id": "split_0_train_2737_passage",
"type": "progene_text",
"text": [
"Overexpression of AR increased osmotic and oxidative stresses , resulting in increased apoptosis in hLECs ."
],
"offsets": [
[
0,
107
]
]
}
]
| [
{
"id": "split_0_train_4307_entity",
"type": "progene_text",
"text": [
"AR"
],
"offsets": [
[
18,
20
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2738 | split_0_train_2738 | [
{
"id": "split_0_train_2738_passage",
"type": "progene_text",
"text": [
"Because AOP2 protects hyperglycemia - induced hLEC apoptosis , this molecule may have the potential to prevent hyperglycemia - mediated complications in diabetes ."
],
"offsets": [
[
0,
163
]
]
}
]
| [
{
"id": "split_0_train_4308_entity",
"type": "progene_text",
"text": [
"AOP2"
],
"offsets": [
[
8,
12
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2739 | split_0_train_2739 | [
{
"id": "split_0_train_2739_passage",
"type": "progene_text",
"text": [
"Simple electrostatic interaction mechanisms in the service of HIV-1 pathogenesis ."
],
"offsets": [
[
0,
82
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2740 | split_0_train_2740 | [
{
"id": "split_0_train_2740_passage",
"type": "progene_text",
"text": [
"The main cell population affected by the human immunodeficiency virus-1 ( HIV-1 ) infection belongs to the CD4 + T - lymphocyte family ."
],
"offsets": [
[
0,
136
]
]
}
]
| [
{
"id": "split_0_train_4309_entity",
"type": "progene_text",
"text": [
"CD4"
],
"offsets": [
[
107,
110
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2741 | split_0_train_2741 | [
{
"id": "split_0_train_2741_passage",
"type": "progene_text",
"text": [
"Recent convincing evidence indicates that the majority of the cells that die due to HIV-1 are not actually infected by the virus ."
],
"offsets": [
[
0,
130
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2742 | split_0_train_2742 | [
{
"id": "split_0_train_2742_passage",
"type": "progene_text",
"text": [
"Instead , these cells are being led to programmed cell death after the activation of apoptotic mechanisms by the virus or its components ."
],
"offsets": [
[
0,
138
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2743 | split_0_train_2743 | [
{
"id": "split_0_train_2743_passage",
"type": "progene_text",
"text": [
"We propose here from accumulated evidence that the virus appears to deregulate the physiological function of these cells during the process of antigen presentation ."
],
"offsets": [
[
0,
165
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2744 | split_0_train_2744 | [
{
"id": "split_0_train_2744_passage",
"type": "progene_text",
"text": [
"Ionic interactions between the variable V3 domain of the HIV-1 coat glycoprotein gp120 and the amino terminal of the chemokine receptor CCR5 play a prominent role in this process , and we speculate that nature has evolved simple electrostatic interaction mechanisms which , coupled to specific recognition systems on the cell surface , can initiate and modulate certain cellular events without the need for specific molecular structures ."
],
"offsets": [
[
0,
438
]
]
}
]
| [
{
"id": "split_0_train_4310_entity",
"type": "progene_text",
"text": [
"gp120"
],
"offsets": [
[
81,
86
]
],
"normalized": []
},
{
"id": "split_0_train_4311_entity",
"type": "progene_text",
"text": [
"chemokine receptor"
],
"offsets": [
[
117,
135
]
],
"normalized": []
},
{
"id": "split_0_train_4312_entity",
"type": "progene_text",
"text": [
"CCR5"
],
"offsets": [
[
136,
140
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2745 | split_0_train_2745 | [
{
"id": "split_0_train_2745_passage",
"type": "progene_text",
"text": [
"HIV-1 utilizes such a mechanism to ensure activation of the target host cell ."
],
"offsets": [
[
0,
78
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2746 | split_0_train_2746 | [
{
"id": "split_0_train_2746_passage",
"type": "progene_text",
"text": [
"Interleukin-1 beta inhibits Na+-K+ ATPase activity and protein expression in cardiac myocytes ."
],
"offsets": [
[
0,
95
]
]
}
]
| [
{
"id": "split_0_train_4313_entity",
"type": "progene_text",
"text": [
"Interleukin-1 beta"
],
"offsets": [
[
0,
18
]
],
"normalized": []
},
{
"id": "split_0_train_4314_entity",
"type": "progene_text",
"text": [
"Na+-K+ ATPase"
],
"offsets": [
[
28,
41
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2747 | split_0_train_2747 | [
{
"id": "split_0_train_2747_passage",
"type": "progene_text",
"text": [
"Recent studies have shown that heart diseases are always accompanied with high levels of IL-1beta and a decrease in Na+-K+ ATPase concentrations ."
],
"offsets": [
[
0,
146
]
]
}
]
| [
{
"id": "split_0_train_4315_entity",
"type": "progene_text",
"text": [
"IL-1beta"
],
"offsets": [
[
89,
97
]
],
"normalized": []
},
{
"id": "split_0_train_4316_entity",
"type": "progene_text",
"text": [
"Na+-K+ ATPase"
],
"offsets": [
[
116,
129
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2748 | split_0_train_2748 | [
{
"id": "split_0_train_2748_passage",
"type": "progene_text",
"text": [
"This work studies the involvement of the cytokine in the observed changes in the pump ."
],
"offsets": [
[
0,
87
]
]
}
]
| [
{
"id": "split_0_train_4317_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
41,
49
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2749 | split_0_train_2749 | [
{
"id": "split_0_train_2749_passage",
"type": "progene_text",
"text": [
"Rats were injected intraperitoneally with 400 mg of IL-1beta and 4 h later , the heart was isolated and a crude homogenate of the right and left ventricles was prepared and tested for Na+-K+ ATPase activity and protein expression ."
],
"offsets": [
[
0,
231
]
]
}
]
| [
{
"id": "split_0_train_4318_entity",
"type": "progene_text",
"text": [
"IL-1beta"
],
"offsets": [
[
52,
60
]
],
"normalized": []
},
{
"id": "split_0_train_4319_entity",
"type": "progene_text",
"text": [
"Na+-K+ ATPase"
],
"offsets": [
[
184,
197
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2750 | split_0_train_2750 | [
{
"id": "split_0_train_2750_passage",
"type": "progene_text",
"text": [
"IL-1beta inhibited by around 70 % the activity of the ATPase in the left and right ventricles ."
],
"offsets": [
[
0,
95
]
]
}
]
| [
{
"id": "split_0_train_4320_entity",
"type": "progene_text",
"text": [
"IL-1beta"
],
"offsets": [
[
0,
8
]
],
"normalized": []
},
{
"id": "split_0_train_4321_entity",
"type": "progene_text",
"text": [
"ATPase"
],
"offsets": [
[
54,
60
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2751 | split_0_train_2751 | [
{
"id": "split_0_train_2751_passage",
"type": "progene_text",
"text": [
"This inhibition of the pump was ascribed to a decrease in its protein expression as demonstrated by western blot analysis ."
],
"offsets": [
[
0,
123
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2752 | split_0_train_2752 | [
{
"id": "split_0_train_2752_passage",
"type": "progene_text",
"text": [
"A dose and time response study conducted on isolated cardiac myocytes confirmed the inhibitory role of the cytokine on the ATPase and showed that IL-1beta exerts its maximal down - regulatory effect at 2 h and at a dose of 20 ng / ml ."
],
"offsets": [
[
0,
235
]
]
}
]
| [
{
"id": "split_0_train_4322_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
107,
115
]
],
"normalized": []
},
{
"id": "split_0_train_4323_entity",
"type": "progene_text",
"text": [
"ATPase"
],
"offsets": [
[
123,
129
]
],
"normalized": []
},
{
"id": "split_0_train_4324_entity",
"type": "progene_text",
"text": [
"IL-1beta"
],
"offsets": [
[
146,
154
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2753 | split_0_train_2753 | [
{
"id": "split_0_train_2753_passage",
"type": "progene_text",
"text": [
"The cytokine caused also an up - regulation of the NaKCl2 cotransporter ."
],
"offsets": [
[
0,
73
]
]
}
]
| [
{
"id": "split_0_train_4325_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
4,
12
]
],
"normalized": []
},
{
"id": "split_0_train_4326_entity",
"type": "progene_text",
"text": [
"NaKCl2 cotransporter"
],
"offsets": [
[
51,
71
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2754 | split_0_train_2754 | [
{
"id": "split_0_train_2754_passage",
"type": "progene_text",
"text": [
"Both MEK and p38MAPK were shown to be involved in the signaling pathway activated by the cytokine ."
],
"offsets": [
[
0,
99
]
]
}
]
| [
{
"id": "split_0_train_4327_entity",
"type": "progene_text",
"text": [
"MEK"
],
"offsets": [
[
5,
8
]
],
"normalized": []
},
{
"id": "split_0_train_4328_entity",
"type": "progene_text",
"text": [
"p38MAPK"
],
"offsets": [
[
13,
20
]
],
"normalized": []
},
{
"id": "split_0_train_4329_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
89,
97
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2755 | split_0_train_2755 | [
{
"id": "split_0_train_2755_passage",
"type": "progene_text",
"text": [
"It can be concluded that the decrease in the Na+-K+ ATPase concentration observed in heart diseases is a consequence of the accompanying high levels of IL-1beta , and may be responsible for the different symptoms that accompany cardiac ischemia ."
],
"offsets": [
[
0,
246
]
]
}
]
| [
{
"id": "split_0_train_4330_entity",
"type": "progene_text",
"text": [
"Na+-K+ ATPase"
],
"offsets": [
[
45,
58
]
],
"normalized": []
},
{
"id": "split_0_train_4331_entity",
"type": "progene_text",
"text": [
"IL-1beta"
],
"offsets": [
[
152,
160
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2756 | split_0_train_2756 | [
{
"id": "split_0_train_2756_passage",
"type": "progene_text",
"text": [
"Expression of the chitobiose operon of Escherichia coli is regulated by three transcription factors : NagC , ChbR and CAP ."
],
"offsets": [
[
0,
123
]
]
}
]
| [
{
"id": "split_0_train_4332_entity",
"type": "progene_text",
"text": [
"chitobiose operon"
],
"offsets": [
[
18,
35
]
],
"normalized": []
},
{
"id": "split_0_train_4333_entity",
"type": "progene_text",
"text": [
"transcription factors"
],
"offsets": [
[
78,
99
]
],
"normalized": []
},
{
"id": "split_0_train_4334_entity",
"type": "progene_text",
"text": [
"NagC"
],
"offsets": [
[
102,
106
]
],
"normalized": []
},
{
"id": "split_0_train_4335_entity",
"type": "progene_text",
"text": [
"ChbR"
],
"offsets": [
[
109,
113
]
],
"normalized": []
},
{
"id": "split_0_train_4336_entity",
"type": "progene_text",
"text": [
"CAP"
],
"offsets": [
[
118,
121
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2757 | split_0_train_2757 | [
{
"id": "split_0_train_2757_passage",
"type": "progene_text",
"text": [
"The chitobiose operon , chbBCARFG , encodes genes for the transport and degradation of the N-acetylglucosamine disaccharide , chitobiose ."
],
"offsets": [
[
0,
138
]
]
}
]
| [
{
"id": "split_0_train_4337_entity",
"type": "progene_text",
"text": [
"chitobiose operon"
],
"offsets": [
[
4,
21
]
],
"normalized": []
},
{
"id": "split_0_train_4338_entity",
"type": "progene_text",
"text": [
"chbBCARFG"
],
"offsets": [
[
24,
33
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2758 | split_0_train_2758 | [
{
"id": "split_0_train_2758_passage",
"type": "progene_text",
"text": [
"Chitobiose is transported by the phosphotransferase system ( PTS ) producing chitobiose-6P which is hydrolysed to GlcNAc-6P by the chbF gene product and then further degraded by the nagBA gene products ."
],
"offsets": [
[
0,
203
]
]
}
]
| [
{
"id": "split_0_train_4339_entity",
"type": "progene_text",
"text": [
"phosphotransferase system"
],
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[
33,
58
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],
"normalized": []
},
{
"id": "split_0_train_4340_entity",
"type": "progene_text",
"text": [
"PTS"
],
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[
61,
64
]
],
"normalized": []
},
{
"id": "split_0_train_4341_entity",
"type": "progene_text",
"text": [
"chbF"
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131,
135
]
],
"normalized": []
},
{
"id": "split_0_train_4342_entity",
"type": "progene_text",
"text": [
"nagBA"
],
"offsets": [
[
182,
187
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2759 | split_0_train_2759 | [
{
"id": "split_0_train_2759_passage",
"type": "progene_text",
"text": [
"Expression of the chb operon is repressed by NagC , which regulates genes involved in amino sugar metabolism ."
],
"offsets": [
[
0,
110
]
]
}
]
| [
{
"id": "split_0_train_4343_entity",
"type": "progene_text",
"text": [
"chb operon"
],
"offsets": [
[
18,
28
]
],
"normalized": []
},
{
"id": "split_0_train_4344_entity",
"type": "progene_text",
"text": [
"NagC"
],
"offsets": [
[
45,
49
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2760 | split_0_train_2760 | [
{
"id": "split_0_train_2760_passage",
"type": "progene_text",
"text": [
"The inducer for NagC is GlcNAc-6P ."
],
"offsets": [
[
0,
35
]
]
}
]
| [
{
"id": "split_0_train_4345_entity",
"type": "progene_text",
"text": [
"NagC"
],
"offsets": [
[
16,
20
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2761 | split_0_train_2761 | [
{
"id": "split_0_train_2761_passage",
"type": "progene_text",
"text": [
"NagC binds to two sites separated by 115 bp and the transcription start point of the chb operon lies within the downstream NagC operator ."
],
"offsets": [
[
0,
138
]
]
}
]
| [
{
"id": "split_0_train_4346_entity",
"type": "progene_text",
"text": [
"NagC"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_4347_entity",
"type": "progene_text",
"text": [
"chb operon"
],
"offsets": [
[
85,
95
]
],
"normalized": []
},
{
"id": "split_0_train_4348_entity",
"type": "progene_text",
"text": [
"NagC"
],
"offsets": [
[
123,
127
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2762 | split_0_train_2762 | [
{
"id": "split_0_train_2762_passage",
"type": "progene_text",
"text": [
"In addition the chb operon encodes its own specific regulator , ChbR , an AraC - type dual repressor - activator , which binds to two direct repeats of 19 bp located between the two NagC sites ."
],
"offsets": [
[
0,
194
]
]
}
]
| [
{
"id": "split_0_train_4349_entity",
"type": "progene_text",
"text": [
"chb operon"
],
"offsets": [
[
16,
26
]
],
"normalized": []
},
{
"id": "split_0_train_4350_entity",
"type": "progene_text",
"text": [
"ChbR"
],
"offsets": [
[
64,
68
]
],
"normalized": []
},
{
"id": "split_0_train_4351_entity",
"type": "progene_text",
"text": [
"AraC"
],
"offsets": [
[
74,
78
]
],
"normalized": []
},
{
"id": "split_0_train_4352_entity",
"type": "progene_text",
"text": [
"NagC"
],
"offsets": [
[
182,
186
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2763 | split_0_train_2763 | [
{
"id": "split_0_train_2763_passage",
"type": "progene_text",
"text": [
"ChbR is necessary for transcription activation in the presence of chitobiose in vivo ."
],
"offsets": [
[
0,
86
]
]
}
]
| [
{
"id": "split_0_train_4353_entity",
"type": "progene_text",
"text": [
"ChbR"
],
"offsets": [
[
0,
4
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2764 | split_0_train_2764 | [
{
"id": "split_0_train_2764_passage",
"type": "progene_text",
"text": [
"Induction of the operon also requires CAP , which binds to a site upstream of the ChbR repeats ."
],
"offsets": [
[
0,
96
]
]
}
]
| [
{
"id": "split_0_train_4354_entity",
"type": "progene_text",
"text": [
"CAP"
],
"offsets": [
[
38,
41
]
],
"normalized": []
},
{
"id": "split_0_train_4355_entity",
"type": "progene_text",
"text": [
"ChbR"
],
"offsets": [
[
82,
86
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2765 | split_0_train_2765 | [
{
"id": "split_0_train_2765_passage",
"type": "progene_text",
"text": [
"In the absence of chitobiose both NagC and ChbR act as repressors ."
],
"offsets": [
[
0,
67
]
]
}
]
| [
{
"id": "split_0_train_4356_entity",
"type": "progene_text",
"text": [
"NagC"
],
"offsets": [
[
34,
38
]
],
"normalized": []
},
{
"id": "split_0_train_4357_entity",
"type": "progene_text",
"text": [
"ChbR"
],
"offsets": [
[
43,
47
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2766 | split_0_train_2766 | [
{
"id": "split_0_train_2766_passage",
"type": "progene_text",
"text": [
"Together these three factors cooperate in switching chb expression from the repressed to the activated state ."
],
"offsets": [
[
0,
110
]
]
}
]
| [
{
"id": "split_0_train_4358_entity",
"type": "progene_text",
"text": [
"chb"
],
"offsets": [
[
52,
55
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2767 | split_0_train_2767 | [
{
"id": "split_0_train_2767_passage",
"type": "progene_text",
"text": [
"The need for two specific inducing signals , one for ChbR to activate the expression of the operon and a second for NagC to relieve its repression , ensure that the chb operon is only induced when there is sufficient flux through the combined chb - nag metabolic pathway to activate expression of both the chb and nag operons ."
],
"offsets": [
[
0,
327
]
]
}
]
| [
{
"id": "split_0_train_4359_entity",
"type": "progene_text",
"text": [
"ChbR"
],
"offsets": [
[
53,
57
]
],
"normalized": []
},
{
"id": "split_0_train_4360_entity",
"type": "progene_text",
"text": [
"NagC"
],
"offsets": [
[
116,
120
]
],
"normalized": []
},
{
"id": "split_0_train_4361_entity",
"type": "progene_text",
"text": [
"chb operon"
],
"offsets": [
[
165,
175
]
],
"normalized": []
},
{
"id": "split_0_train_4362_entity",
"type": "progene_text",
"text": [
"chb"
],
"offsets": [
[
243,
246
]
],
"normalized": []
},
{
"id": "split_0_train_4363_entity",
"type": "progene_text",
"text": [
"nag"
],
"offsets": [
[
249,
252
]
],
"normalized": []
},
{
"id": "split_0_train_4364_entity",
"type": "progene_text",
"text": [
"chb and nag operons"
],
"offsets": [
[
306,
325
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2768 | split_0_train_2768 | [
{
"id": "split_0_train_2768_passage",
"type": "progene_text",
"text": [
"Tumor galectinology : insights into the complex network of a family of endogenous lectins ."
],
"offsets": [
[
0,
91
]
]
}
]
| [
{
"id": "split_0_train_4365_entity",
"type": "progene_text",
"text": [
"lectins"
],
"offsets": [
[
82,
89
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2769 | split_0_train_2769 | [
{
"id": "split_0_train_2769_passage",
"type": "progene_text",
"text": [
"Beta - Galactosides of cell surface glycoconjugates are docking sites for endogenous lectins of the galectin family ."
],
"offsets": [
[
0,
117
]
]
}
]
| [
{
"id": "split_0_train_4366_entity",
"type": "progene_text",
"text": [
"lectins of the galectin family"
],
"offsets": [
[
85,
115
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2770 | split_0_train_2770 | [
{
"id": "split_0_train_2770_passage",
"type": "progene_text",
"text": [
"In cancer cells , primarily galectins - 1 and - 3 have been studied to date ."
],
"offsets": [
[
0,
77
]
]
}
]
| [
{
"id": "split_0_train_4367_entity",
"type": "progene_text",
"text": [
"galectins - 1 and - 3"
],
"offsets": [
[
28,
49
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2771 | split_0_train_2771 | [
{
"id": "split_0_train_2771_passage",
"type": "progene_text",
"text": [
"With the emergence of insights into their role in growth control , resistance to or induction of apoptosis and invasive behavior the notion is supported that they can be considered as functional tumor markers ."
],
"offsets": [
[
0,
210
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2772 | split_0_train_2772 | [
{
"id": "split_0_train_2772_passage",
"type": "progene_text",
"text": [
"In principle , the same might hold true for the other members of the galectin family ."
],
"offsets": [
[
0,
86
]
]
}
]
| [
{
"id": "split_0_train_4368_entity",
"type": "progene_text",
"text": [
"galectin family"
],
"offsets": [
[
69,
84
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2773 | split_0_train_2773 | [
{
"id": "split_0_train_2773_passage",
"type": "progene_text",
"text": [
"But their expression in tumors has hitherto been a subject of attention only to a very limited extent ."
],
"offsets": [
[
0,
103
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2774 | split_0_train_2774 | [
{
"id": "split_0_train_2774_passage",
"type": "progene_text",
"text": [
"Pursuing our concept to define the complexity of the galectin network in cancer cells and the degree of functional overlap / divergence with diagnostic / therapeutic implications , we have introduced comprehensive RT - PCR monitoring to map their galectin gene expression ."
],
"offsets": [
[
0,
273
]
]
}
]
| [
{
"id": "split_0_train_4369_entity",
"type": "progene_text",
"text": [
"galectin"
],
"offsets": [
[
53,
61
]
],
"normalized": []
},
{
"id": "split_0_train_4370_entity",
"type": "progene_text",
"text": [
"galectin"
],
"offsets": [
[
247,
255
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2775 | split_0_train_2775 | [
{
"id": "split_0_train_2775_passage",
"type": "progene_text",
"text": [
"The data on so far less appreciated galectins in this context such as galectins-4 and - 8 vindicate this approach ."
],
"offsets": [
[
0,
115
]
]
}
]
| [
{
"id": "split_0_train_4371_entity",
"type": "progene_text",
"text": [
"galectins"
],
"offsets": [
[
36,
45
]
],
"normalized": []
},
{
"id": "split_0_train_4372_entity",
"type": "progene_text",
"text": [
"galectins-4 and - 8"
],
"offsets": [
[
70,
89
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2776 | split_0_train_2776 | [
{
"id": "split_0_train_2776_passage",
"type": "progene_text",
"text": [
"They , too , attach value to extend the immunohistochemical panel accordingly ."
],
"offsets": [
[
0,
79
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2777 | split_0_train_2777 | [
{
"id": "split_0_train_2777_passage",
"type": "progene_text",
"text": [
"Our initial histopathological and cell biological studies , for example on colon cancer progression , prove the merit of this procedure ."
],
"offsets": [
[
0,
137
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2778 | split_0_train_2778 | [
{
"id": "split_0_train_2778_passage",
"type": "progene_text",
"text": [
"Aside from the detection of gene expression profiles by RT - PCR , the detailed molecular biological monitoring yielded further important information ."
],
"offsets": [
[
0,
151
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2779 | split_0_train_2779 | [
{
"id": "split_0_train_2779_passage",
"type": "progene_text",
"text": [
"We describe different levels of regulation of galectin production in colon cancer cells in the cases of the tandem - repeat - type galectins - 8 and - 9 ."
],
"offsets": [
[
0,
154
]
]
}
]
| [
{
"id": "split_0_train_4373_entity",
"type": "progene_text",
"text": [
"galectin"
],
"offsets": [
[
46,
54
]
],
"normalized": []
},
{
"id": "split_0_train_4374_entity",
"type": "progene_text",
"text": [
"galectins - 8 and - 9"
],
"offsets": [
[
131,
152
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2780 | split_0_train_2780 | [
{
"id": "split_0_train_2780_passage",
"type": "progene_text",
"text": [
"Isoforms for them are present with insertions into the peptide linker sequence attributed to alternative splicing ."
],
"offsets": [
[
0,
115
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2781 | split_0_train_2781 | [
{
"id": "split_0_train_2781_passage",
"type": "progene_text",
"text": [
"Furthermore , variants with distinct amino acid substitutions ( galectin - 8 , Po66-CBP , PCTA-1 , CocaI / II and galectin-9 / ecalectin ) and generation of multiple mRNA species , notably those coding for truncated galectin - 8 and - 9 versions with only one lectin site , justify to portray these two family members not as distinct individuals but as groups ."
],
"offsets": [
[
0,
361
]
]
}
]
| [
{
"id": "split_0_train_4375_entity",
"type": "progene_text",
"text": [
"galectin - 8"
],
"offsets": [
[
64,
76
]
],
"normalized": []
},
{
"id": "split_0_train_4376_entity",
"type": "progene_text",
"text": [
"Po66-CBP"
],
"offsets": [
[
79,
87
]
],
"normalized": []
},
{
"id": "split_0_train_4377_entity",
"type": "progene_text",
"text": [
"PCTA-1"
],
"offsets": [
[
90,
96
]
],
"normalized": []
},
{
"id": "split_0_train_4378_entity",
"type": "progene_text",
"text": [
"CocaI / II"
],
"offsets": [
[
99,
109
]
],
"normalized": []
},
{
"id": "split_0_train_4379_entity",
"type": "progene_text",
"text": [
"galectin-9"
],
"offsets": [
[
114,
124
]
],
"normalized": []
},
{
"id": "split_0_train_4380_entity",
"type": "progene_text",
"text": [
"ecalectin"
],
"offsets": [
[
127,
136
]
],
"normalized": []
},
{
"id": "split_0_train_4381_entity",
"type": "progene_text",
"text": [
"galectin - 8 and - 9"
],
"offsets": [
[
216,
236
]
],
"normalized": []
},
{
"id": "split_0_train_4382_entity",
"type": "progene_text",
"text": [
"lectin"
],
"offsets": [
[
260,
266
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2782 | split_0_train_2782 | [
{
"id": "split_0_train_2782_passage",
"type": "progene_text",
"text": [
"In aggregate , the ongoing work to thoroughly chart the galectin network and to disentangle the individual functional contributions is expected to make its mark on our understanding of the malignant phenotype in certain tumor types ."
],
"offsets": [
[
0,
233
]
]
}
]
| [
{
"id": "split_0_train_4383_entity",
"type": "progene_text",
"text": [
"galectin"
],
"offsets": [
[
56,
64
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2783 | split_0_train_2783 | [
{
"id": "split_0_train_2783_passage",
"type": "progene_text",
"text": [
"Pathogens and symbionts in ticks : prevalence of Anaplasma phagocytophilum ( Ehrlichia sp. ) , Wolbachia sp. , Rickettsia sp. , and Babesia sp. in Southern Germany ."
],
"offsets": [
[
0,
165
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2784 | split_0_train_2784 | [
{
"id": "split_0_train_2784_passage",
"type": "progene_text",
"text": [
"Tick - transmitted diseases like tick - borne encephalitis and Lyme borreliosis have been well known in Germany for decades ."
],
"offsets": [
[
0,
125
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2785 | split_0_train_2785 | [
{
"id": "split_0_train_2785_passage",
"type": "progene_text",
"text": [
"Ongoing research now gives an additional focus to a broad range of other bacteria and parasites in ticks like Anaplasma phagocytophilum , former Ehrlichia sp. , Rickettsia sp. and Babesia sp. Knowledge about the prevalence of these infectious agents in ticks is an important prerequisite for risk assessment of human diseases ."
],
"offsets": [
[
0,
327
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2786 | split_0_train_2786 | [
{
"id": "split_0_train_2786_passage",
"type": "progene_text",
"text": [
"Therefore nymphs and adult Ixodes ricinus ticks were collected and examined for Anaplasma phagocytophilum ( n = 5424 ticks ) , Rickettsia sp. ( n = 1187 ) , and Babesia sp. ( n = 3113 ) ."
],
"offsets": [
[
0,
187
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2787 | split_0_train_2787 | [
{
"id": "split_0_train_2787_passage",
"type": "progene_text",
"text": [
"For the detection of Anaplasma phagocytophilum , DNA from the 16S rDNA gene was amplified by nested PCR and hybridized with a DIG - labeled oligonucleotide probe ."
],
"offsets": [
[
0,
163
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2788 | split_0_train_2788 | [
{
"id": "split_0_train_2788_passage",
"type": "progene_text",
"text": [
"The examination of Rickettsia sp. was performed by single PCR ."
],
"offsets": [
[
0,
63
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2789 | split_0_train_2789 | [
{
"id": "split_0_train_2789_passage",
"type": "progene_text",
"text": [
"A partial sequence of the citrate synthase gene was amplified ."
],
"offsets": [
[
0,
63
]
]
}
]
| [
{
"id": "split_0_train_4384_entity",
"type": "progene_text",
"text": [
"citrate synthase"
],
"offsets": [
[
26,
42
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2790 | split_0_train_2790 | [
{
"id": "split_0_train_2790_passage",
"type": "progene_text",
"text": [
"As a target for the detection of Babesia sp. , DNA from the 18S rDNA gene was amplified , also by single PCR ."
],
"offsets": [
[
0,
110
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2791 | split_0_train_2791 | [
{
"id": "split_0_train_2791_passage",
"type": "progene_text",
"text": [
"All positive PCR products were sequenced to control specificity ."
],
"offsets": [
[
0,
65
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2792 | split_0_train_2792 | [
{
"id": "split_0_train_2792_passage",
"type": "progene_text",
"text": [
"Anaplasma phagocytophilum was detected by PCR in n = 103 ( 1.9 % ) out of 5,424 examined ticks from 11 investigation areas ."
],
"offsets": [
[
0,
124
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2793 | split_0_train_2793 | [
{
"id": "split_0_train_2793_passage",
"type": "progene_text",
"text": [
"However , not all positive PCR products hybridized using DIG - labeled oligonucleotide probe ."
],
"offsets": [
[
0,
94
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2794 | split_0_train_2794 | [
{
"id": "split_0_train_2794_passage",
"type": "progene_text",
"text": [
"Thus , the result of sequencing indicated that only 1.0 % ( n = 54 ) belonged to Anaplasma phagocytophilum and nearly half of these PCR products ( 0.9 % ) were identified as Wolbachia sp. Rickettsia sp. in Ixodes ricinus ticks from 3 areas were found in n = 105 ( 8.9 % ) out of 1,187 ticks examined ( range from 13.3 % to 5.6 % ) ."
],
"offsets": [
[
0,
332
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2795 | split_0_train_2795 | [
{
"id": "split_0_train_2795_passage",
"type": "progene_text",
"text": [
"Sequencing showed Rickettsia helvetica exclusively ."
],
"offsets": [
[
0,
52
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2796 | split_0_train_2796 | [
{
"id": "split_0_train_2796_passage",
"type": "progene_text",
"text": [
"In about 2.6 % of Rickettsia - positive ticks , double infection with Anaplasma phagocytophilum was found ."
],
"offsets": [
[
0,
107
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2797 | split_0_train_2797 | [
{
"id": "split_0_train_2797_passage",
"type": "progene_text",
"text": [
"Babesia sp. was detected in n = 31 ( 1.0 % ) out of 3,113 ticks examined , which originated from 4 different areas ."
],
"offsets": [
[
0,
116
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2798 | split_0_train_2798 | [
{
"id": "split_0_train_2798_passage",
"type": "progene_text",
"text": [
"By sequencing , n = 28 ( 90.0 % ) were identified as Babesia divergens ."
],
"offsets": [
[
0,
72
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2799 | split_0_train_2799 | [
{
"id": "split_0_train_2799_passage",
"type": "progene_text",
"text": [
"Three of all Babesia - positive ticks were identified as harboring Babesia microti ."
],
"offsets": [
[
0,
84
]
]
}
]
| []
| []
| []
| []
|
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