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stringlengths 15
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split_0_train_2800 | split_0_train_2800 | [
{
"id": "split_0_train_2800_passage",
"type": "progene_text",
"text": [
"The detection of Anaplasma phagocytophilum , Rickettsia sp. and Babesia sp. demonstrates their possible role as a source of human infection in Germany ."
],
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[
0,
152
]
]
}
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| []
| []
| []
| []
|
split_0_train_2801 | split_0_train_2801 | [
{
"id": "split_0_train_2801_passage",
"type": "progene_text",
"text": [
"KIR2DL5 can inhibit human NK cell activation via recruitment of Src homology region 2 - containing protein tyrosine phosphatase-2 ( SHP-2 ) ."
],
"offsets": [
[
0,
141
]
]
}
]
| [
{
"id": "split_0_train_4385_entity",
"type": "progene_text",
"text": [
"KIR2DL5"
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[
0,
7
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{
"id": "split_0_train_4386_entity",
"type": "progene_text",
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"Src homology region 2 - containing protein tyrosine phosphatase-2"
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64,
129
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{
"id": "split_0_train_4387_entity",
"type": "progene_text",
"text": [
"SHP-2"
],
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[
132,
137
]
],
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}
]
| []
| []
| []
|
split_0_train_2802 | split_0_train_2802 | [
{
"id": "split_0_train_2802_passage",
"type": "progene_text",
"text": [
"Human NK cells use class I MHC - binding inhibitory receptors , such as the killer cell Ig - like receptor ( KIR ) family , to discriminate between normal and abnormal cells ."
],
"offsets": [
[
0,
175
]
]
}
]
| [
{
"id": "split_0_train_4388_entity",
"type": "progene_text",
"text": [
"class I MHC"
],
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[
19,
30
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},
{
"id": "split_0_train_4389_entity",
"type": "progene_text",
"text": [
"killer cell Ig - like receptor ( KIR ) family"
],
"offsets": [
[
76,
121
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2803 | split_0_train_2803 | [
{
"id": "split_0_train_2803_passage",
"type": "progene_text",
"text": [
"Some tumors and virus - infected cells down - regulate class I MHC and thereby become targets of NK cells ."
],
"offsets": [
[
0,
107
]
]
}
]
| [
{
"id": "split_0_train_4390_entity",
"type": "progene_text",
"text": [
"class I MHC"
],
"offsets": [
[
55,
66
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2804 | split_0_train_2804 | [
{
"id": "split_0_train_2804_passage",
"type": "progene_text",
"text": [
"Substantial evidence indicates that the mechanism of KIR - mediated inhibition involves recruitment of the protein tyrosine phosphatases , Src homology 2 - containing protein tyrosine phosphatase-1 ( SHP-1 ) and SHP-2 , to two phosphorylated cytoplasmic immunoreceptor tyrosine - based inhibitory motifs ( ITIMs ) ."
],
"offsets": [
[
0,
315
]
]
}
]
| [
{
"id": "split_0_train_4391_entity",
"type": "progene_text",
"text": [
"KIR"
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[
53,
56
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{
"id": "split_0_train_4392_entity",
"type": "progene_text",
"text": [
"protein tyrosine phosphatases"
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107,
136
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{
"id": "split_0_train_4393_entity",
"type": "progene_text",
"text": [
"Src homology 2 - containing protein tyrosine phosphatase-1"
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[
139,
197
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},
{
"id": "split_0_train_4394_entity",
"type": "progene_text",
"text": [
"SHP-1"
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[
200,
205
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{
"id": "split_0_train_4395_entity",
"type": "progene_text",
"text": [
"SHP-2"
],
"offsets": [
[
212,
217
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2805 | split_0_train_2805 | [
{
"id": "split_0_train_2805_passage",
"type": "progene_text",
"text": [
"KIR2DL5 is a type II member of the KIR2D family with an atypical extracellular domain and an intracytoplasmic domain containing one typical ITIM and one atypical ITIM sequence ."
],
"offsets": [
[
0,
177
]
]
}
]
| [
{
"id": "split_0_train_4396_entity",
"type": "progene_text",
"text": [
"KIR2DL5"
],
"offsets": [
[
0,
7
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},
{
"id": "split_0_train_4397_entity",
"type": "progene_text",
"text": [
"KIR2D family"
],
"offsets": [
[
35,
47
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2806 | split_0_train_2806 | [
{
"id": "split_0_train_2806_passage",
"type": "progene_text",
"text": [
"Although KIR2DL5 structure is expressed by approximately 50 % of humans and is conserved among primate species , its function has not been determined ."
],
"offsets": [
[
0,
151
]
]
}
]
| [
{
"id": "split_0_train_4398_entity",
"type": "progene_text",
"text": [
"KIR2DL5"
],
"offsets": [
[
9,
16
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2807 | split_0_train_2807 | [
{
"id": "split_0_train_2807_passage",
"type": "progene_text",
"text": [
"In the present study , we directly compared functional and biochemical properties of KIR2DL5 , KIR3DL1 ( a type I KIR with two ITIMs ) , and KIR2DL4 ( the only other type II KIR , which has a single ITIM ) in a human NK - like cell line ."
],
"offsets": [
[
0,
238
]
]
}
]
| [
{
"id": "split_0_train_4399_entity",
"type": "progene_text",
"text": [
"KIR2DL5"
],
"offsets": [
[
85,
92
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],
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{
"id": "split_0_train_4400_entity",
"type": "progene_text",
"text": [
"KIR3DL1"
],
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[
95,
102
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],
"normalized": []
},
{
"id": "split_0_train_4401_entity",
"type": "progene_text",
"text": [
"KIR"
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"offsets": [
[
114,
117
]
],
"normalized": []
},
{
"id": "split_0_train_4402_entity",
"type": "progene_text",
"text": [
"KIR2DL4"
],
"offsets": [
[
141,
148
]
],
"normalized": []
},
{
"id": "split_0_train_4403_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
174,
177
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2808 | split_0_train_2808 | [
{
"id": "split_0_train_2808_passage",
"type": "progene_text",
"text": [
"Our results show that KIR2DL5 is an inhibitory receptor that can recruit both SHP-1 and SHP-2 , and its inhibitory capacity is more similar to that of the cytoplasmic domain of KIR2DL4 than KIR3DL1 ."
],
"offsets": [
[
0,
199
]
]
}
]
| [
{
"id": "split_0_train_4404_entity",
"type": "progene_text",
"text": [
"KIR2DL5"
],
"offsets": [
[
22,
29
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],
"normalized": []
},
{
"id": "split_0_train_4405_entity",
"type": "progene_text",
"text": [
"SHP-1"
],
"offsets": [
[
78,
83
]
],
"normalized": []
},
{
"id": "split_0_train_4406_entity",
"type": "progene_text",
"text": [
"SHP-2"
],
"offsets": [
[
88,
93
]
],
"normalized": []
},
{
"id": "split_0_train_4407_entity",
"type": "progene_text",
"text": [
"KIR2DL4"
],
"offsets": [
[
177,
184
]
],
"normalized": []
},
{
"id": "split_0_train_4408_entity",
"type": "progene_text",
"text": [
"KIR3DL1"
],
"offsets": [
[
190,
197
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2809 | split_0_train_2809 | [
{
"id": "split_0_train_2809_passage",
"type": "progene_text",
"text": [
"Interestingly , inhibition of NK cell cytotoxicity by KIR2DL5 was blocked by dominant - negative SHP-2 , but not dominant - negative SHP-1 , whereas both dominant - negative phosphatases can block inhibition by KIR3DL1 ."
],
"offsets": [
[
0,
220
]
]
}
]
| [
{
"id": "split_0_train_4409_entity",
"type": "progene_text",
"text": [
"KIR2DL5"
],
"offsets": [
[
54,
61
]
],
"normalized": []
},
{
"id": "split_0_train_4410_entity",
"type": "progene_text",
"text": [
"SHP-2"
],
"offsets": [
[
97,
102
]
],
"normalized": []
},
{
"id": "split_0_train_4411_entity",
"type": "progene_text",
"text": [
"SHP-1"
],
"offsets": [
[
133,
138
]
],
"normalized": []
},
{
"id": "split_0_train_4412_entity",
"type": "progene_text",
"text": [
"phosphatases"
],
"offsets": [
[
174,
186
]
],
"normalized": []
},
{
"id": "split_0_train_4413_entity",
"type": "progene_text",
"text": [
"KIR3DL1"
],
"offsets": [
[
211,
218
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2810 | split_0_train_2810 | [
{
"id": "split_0_train_2810_passage",
"type": "progene_text",
"text": [
"Therefore , the cytoplasmic domains of type II KIRs ( 2DL4 and 2DL5 ) exhibit distinct inhibitory capacities when compared with type I KIRs ( 3DL1 ) , due to alterations in the canonical ITIM sequences ."
],
"offsets": [
[
0,
203
]
]
}
]
| [
{
"id": "split_0_train_4414_entity",
"type": "progene_text",
"text": [
"KIRs"
],
"offsets": [
[
47,
51
]
],
"normalized": []
},
{
"id": "split_0_train_4415_entity",
"type": "progene_text",
"text": [
"2DL4"
],
"offsets": [
[
54,
58
]
],
"normalized": []
},
{
"id": "split_0_train_4416_entity",
"type": "progene_text",
"text": [
"2DL5"
],
"offsets": [
[
63,
67
]
],
"normalized": []
},
{
"id": "split_0_train_4417_entity",
"type": "progene_text",
"text": [
"KIRs"
],
"offsets": [
[
135,
139
]
],
"normalized": []
},
{
"id": "split_0_train_4418_entity",
"type": "progene_text",
"text": [
"3DL1"
],
"offsets": [
[
142,
146
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2811 | split_0_train_2811 | [
{
"id": "split_0_train_2811_passage",
"type": "progene_text",
"text": [
"A chitinase indispensable for formation of protoplast of Schizophyllum commune in basidiomycete - lytic enzyme preparation produced by Bacillus circulans KA-304 ."
],
"offsets": [
[
0,
162
]
]
}
]
| [
{
"id": "split_0_train_4419_entity",
"type": "progene_text",
"text": [
"chitinase"
],
"offsets": [
[
2,
11
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2812 | split_0_train_2812 | [
{
"id": "split_0_train_2812_passage",
"type": "progene_text",
"text": [
"KA - prep , a culture filtrate of Bacillus circulans KA - 304 grown on a cell - wall preparation of Schizophyllum commune , has an activity to form protoplasts from S. commune mycelia ."
],
"offsets": [
[
0,
185
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2813 | split_0_train_2813 | [
{
"id": "split_0_train_2813_passage",
"type": "progene_text",
"text": [
"alpha-1,3-Glucanase , which was isolated from an ammonium sulfate fraction of 0 - 30 % saturation of KA - prep , gave the protoplast - forming activity to an ammonium sulfate fraction of 30 - 50 % saturation of KA - prep , which contained chitinase ( s ) and beta - glucanase ( s ) but was inactive in the protoplast formation ."
],
"offsets": [
[
0,
328
]
]
}
]
| [
{
"id": "split_0_train_4420_entity",
"type": "progene_text",
"text": [
"alpha-1,3-Glucanase"
],
"offsets": [
[
0,
19
]
],
"normalized": []
},
{
"id": "split_0_train_4421_entity",
"type": "progene_text",
"text": [
"chitinase"
],
"offsets": [
[
239,
248
]
],
"normalized": []
},
{
"id": "split_0_train_4422_entity",
"type": "progene_text",
"text": [
"beta - glucanase"
],
"offsets": [
[
259,
275
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2814 | split_0_train_2814 | [
{
"id": "split_0_train_2814_passage",
"type": "progene_text",
"text": [
"Chitinase(s) and beta - glucanase ( s ) in the ammonium sulfate fraction of 30 - 50 % saturation were separated by DEAE - cellulofine A - 500 column chromatography , and the protoplast - forming activity appeared when the chitinase preparation was mixed with the alpha-1 , 3 - glucanase ."
],
"offsets": [
[
0,
288
]
]
}
]
| [
{
"id": "split_0_train_4423_entity",
"type": "progene_text",
"text": [
"Chitinase(s)"
],
"offsets": [
[
0,
12
]
],
"normalized": []
},
{
"id": "split_0_train_4424_entity",
"type": "progene_text",
"text": [
"beta - glucanase"
],
"offsets": [
[
17,
33
]
],
"normalized": []
},
{
"id": "split_0_train_4425_entity",
"type": "progene_text",
"text": [
"chitinase"
],
"offsets": [
[
222,
231
]
],
"normalized": []
},
{
"id": "split_0_train_4426_entity",
"type": "progene_text",
"text": [
"alpha-1 , 3 - glucanase"
],
"offsets": [
[
263,
286
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2815 | split_0_train_2815 | [
{
"id": "split_0_train_2815_passage",
"type": "progene_text",
"text": [
"The beta-glucanase preparation was not effective for the protoplast formation whereas its addition enhanced the protoplast - forming activity of the mixture of alpha-1,3-glucanase and the chitinase preparation ."
],
"offsets": [
[
0,
211
]
]
}
]
| [
{
"id": "split_0_train_4427_entity",
"type": "progene_text",
"text": [
"beta-glucanase"
],
"offsets": [
[
4,
18
]
],
"normalized": []
},
{
"id": "split_0_train_4428_entity",
"type": "progene_text",
"text": [
"alpha-1,3-glucanase"
],
"offsets": [
[
160,
179
]
],
"normalized": []
},
{
"id": "split_0_train_4429_entity",
"type": "progene_text",
"text": [
"chitinase"
],
"offsets": [
[
188,
197
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2816 | split_0_train_2816 | [
{
"id": "split_0_train_2816_passage",
"type": "progene_text",
"text": [
"The chitinase preparation contained two chitinases ( chitinase I and II ) ."
],
"offsets": [
[
0,
75
]
]
}
]
| [
{
"id": "split_0_train_4430_entity",
"type": "progene_text",
"text": [
"chitinase"
],
"offsets": [
[
4,
13
]
],
"normalized": []
},
{
"id": "split_0_train_4431_entity",
"type": "progene_text",
"text": [
"chitinases"
],
"offsets": [
[
40,
50
]
],
"normalized": []
},
{
"id": "split_0_train_4432_entity",
"type": "progene_text",
"text": [
"chitinase I and II"
],
"offsets": [
[
53,
71
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2817 | split_0_train_2817 | [
{
"id": "split_0_train_2817_passage",
"type": "progene_text",
"text": [
"Chitinase I showed the protoplast - forming activity with alpha-1,3-glucanase , but chitinase II did not ."
],
"offsets": [
[
0,
106
]
]
}
]
| [
{
"id": "split_0_train_4433_entity",
"type": "progene_text",
"text": [
"Chitinase I"
],
"offsets": [
[
0,
11
]
],
"normalized": []
},
{
"id": "split_0_train_4434_entity",
"type": "progene_text",
"text": [
"alpha-1,3-glucanase"
],
"offsets": [
[
58,
77
]
],
"normalized": []
},
{
"id": "split_0_train_4435_entity",
"type": "progene_text",
"text": [
"chitinase II"
],
"offsets": [
[
84,
96
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2818 | split_0_train_2818 | [
{
"id": "split_0_train_2818_passage",
"type": "progene_text",
"text": [
"Chitinase I , a monomeric protein with a molecular weight of 41,000 , was active toward colloidal chitin and ethylene glycol chitin ."
],
"offsets": [
[
0,
133
]
]
}
]
| [
{
"id": "split_0_train_4436_entity",
"type": "progene_text",
"text": [
"Chitinase I"
],
"offsets": [
[
0,
11
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2819 | split_0_train_2819 | [
{
"id": "split_0_train_2819_passage",
"type": "progene_text",
"text": [
"Chitinase I produced predominantly N,N'-diacetylchitobiose and N,N',N\"-triacetylchitotriose from colloidal chitin , and the enzyme was inactive to p-NP-beta-D-N-acetylglucosaminide , suggesting that it was an endo - type enzyme ."
],
"offsets": [
[
0,
229
]
]
}
]
| [
{
"id": "split_0_train_4437_entity",
"type": "progene_text",
"text": [
"Chitinase I"
],
"offsets": [
[
0,
11
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2820 | split_0_train_2820 | [
{
"id": "split_0_train_2820_passage",
"type": "progene_text",
"text": [
"The N - terminal amino acid sequence of chitinase I ( A L A T P T L N V S A S S G M ) had no sequential identity to those of known chitinases ."
],
"offsets": [
[
0,
143
]
]
}
]
| [
{
"id": "split_0_train_4438_entity",
"type": "progene_text",
"text": [
"chitinase I"
],
"offsets": [
[
40,
51
]
],
"normalized": []
},
{
"id": "split_0_train_4439_entity",
"type": "progene_text",
"text": [
"chitinases"
],
"offsets": [
[
131,
141
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2821 | split_0_train_2821 | [
{
"id": "split_0_train_2821_passage",
"type": "progene_text",
"text": [
"Methylprednisolone favourably alters plasma and urinary cytokine homeostasis and subclinical renal injury at cardiac surgery ."
],
"offsets": [
[
0,
126
]
]
}
]
| [
{
"id": "split_0_train_4440_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
56,
64
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2822 | split_0_train_2822 | [
{
"id": "split_0_train_2822_passage",
"type": "progene_text",
"text": [
"Whilst elevated urinary transforming growth factor beta-1 ( TGFbeta ) is associated with chronic renal dysfunction its role in acute peri - operative renal dysfunction is unknown ."
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"offsets": [
[
0,
180
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]
}
]
| [
{
"id": "split_0_train_4441_entity",
"type": "progene_text",
"text": [
"transforming growth factor beta-1"
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[
24,
57
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},
{
"id": "split_0_train_4442_entity",
"type": "progene_text",
"text": [
"TGFbeta"
],
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[
60,
67
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2823 | split_0_train_2823 | [
{
"id": "split_0_train_2823_passage",
"type": "progene_text",
"text": [
"In contrast , peri - operative increases in urinary IL-1 receptor antagonist ( IL-1ra ) and TNF soluble receptor-2 ( TNFsr-2 ) mirror pro - inflammatory activity in the nephron and correlate with renal complications ."
],
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[
0,
217
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]
}
]
| [
{
"id": "split_0_train_4443_entity",
"type": "progene_text",
"text": [
"IL-1 receptor antagonist"
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52,
76
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},
{
"id": "split_0_train_4444_entity",
"type": "progene_text",
"text": [
"IL-1ra"
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79,
85
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},
{
"id": "split_0_train_4445_entity",
"type": "progene_text",
"text": [
"TNF soluble receptor-2"
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92,
114
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},
{
"id": "split_0_train_4446_entity",
"type": "progene_text",
"text": [
"TNFsr-2"
],
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[
117,
124
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2824 | split_0_train_2824 | [
{
"id": "split_0_train_2824_passage",
"type": "progene_text",
"text": [
"Steroids modulate some plasma cytokines ( decreasing TNFalpha , IL-8 , IL-6 and increasing IL-10 ) , whereas ability to reduce plasma and urinary TNFsr-2 and IL-1ra and peri - operative renal injury is unknown ."
],
"offsets": [
[
0,
211
]
]
}
]
| [
{
"id": "split_0_train_4447_entity",
"type": "progene_text",
"text": [
"cytokines"
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[
30,
39
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],
"normalized": []
},
{
"id": "split_0_train_4448_entity",
"type": "progene_text",
"text": [
"TNFalpha"
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53,
61
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],
"normalized": []
},
{
"id": "split_0_train_4449_entity",
"type": "progene_text",
"text": [
"IL-8"
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[
64,
68
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],
"normalized": []
},
{
"id": "split_0_train_4450_entity",
"type": "progene_text",
"text": [
"IL-6"
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[
71,
75
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},
{
"id": "split_0_train_4451_entity",
"type": "progene_text",
"text": [
"IL-10"
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[
91,
96
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},
{
"id": "split_0_train_4452_entity",
"type": "progene_text",
"text": [
"TNFsr-2"
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146,
153
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],
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},
{
"id": "split_0_train_4453_entity",
"type": "progene_text",
"text": [
"IL-1ra"
],
"offsets": [
[
158,
164
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2825 | split_0_train_2825 | [
{
"id": "split_0_train_2825_passage",
"type": "progene_text",
"text": [
"Patients undergoing coronary artery bypass grafting with cardiopulmonary bypass ( CPB ) were randomised to receive methylprednisolone ( n = 18 ) or placebo ( n = 17 ) before induction of anaesthesia ."
],
"offsets": [
[
0,
200
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2826 | split_0_train_2826 | [
{
"id": "split_0_train_2826_passage",
"type": "progene_text",
"text": [
"Plasma and urinary pro - and anti - inflammatory cytokine balance was determined along with subclinical proximal tubular injury and dysfunction , measured by urinary N-acetyl-beta-d-glucosaminidase ( NAG ) / creatinine and alpha-1-microglobulin / creatinine ratios , respectively ."
],
"offsets": [
[
0,
281
]
]
}
]
| [
{
"id": "split_0_train_4454_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
49,
57
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2827 | split_0_train_2827 | [
{
"id": "split_0_train_2827_passage",
"type": "progene_text",
"text": [
"In the control group compared with baseline , plasma IL-8 , TNFalpha , IL-10 , IL-1ra and TNFsr-2 were significantly elevated along with urinary IL-1ra , TNFsr-2 and TGFbeta1 ."
],
"offsets": [
[
0,
176
]
]
}
]
| [
{
"id": "split_0_train_4455_entity",
"type": "progene_text",
"text": [
"IL-8"
],
"offsets": [
[
53,
57
]
],
"normalized": []
},
{
"id": "split_0_train_4456_entity",
"type": "progene_text",
"text": [
"TNFalpha"
],
"offsets": [
[
60,
68
]
],
"normalized": []
},
{
"id": "split_0_train_4457_entity",
"type": "progene_text",
"text": [
"IL-10"
],
"offsets": [
[
71,
76
]
],
"normalized": []
},
{
"id": "split_0_train_4458_entity",
"type": "progene_text",
"text": [
"IL-1ra"
],
"offsets": [
[
79,
85
]
],
"normalized": []
},
{
"id": "split_0_train_4459_entity",
"type": "progene_text",
"text": [
"TNFsr-2"
],
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[
90,
97
]
],
"normalized": []
},
{
"id": "split_0_train_4460_entity",
"type": "progene_text",
"text": [
"IL-1ra"
],
"offsets": [
[
145,
151
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],
"normalized": []
},
{
"id": "split_0_train_4461_entity",
"type": "progene_text",
"text": [
"TNFsr-2"
],
"offsets": [
[
154,
161
]
],
"normalized": []
},
{
"id": "split_0_train_4462_entity",
"type": "progene_text",
"text": [
"TGFbeta1"
],
"offsets": [
[
166,
174
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2828 | split_0_train_2828 | [
{
"id": "split_0_train_2828_passage",
"type": "progene_text",
"text": [
"Urinary NAG / creatinine and alpha-1-microglobulin / creatinine ratios rose from completion of revascularisation until 6 h with recovery at 24 h with a further rise in NAG / creatinine ratio at 48 h ."
],
"offsets": [
[
0,
200
]
]
}
]
| [
{
"id": "split_0_train_4463_entity",
"type": "progene_text",
"text": [
"alpha-1-microglobulin"
],
"offsets": [
[
29,
50
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2829 | split_0_train_2829 | [
{
"id": "split_0_train_2829_passage",
"type": "progene_text",
"text": [
"Compared to placebo , the methylprednisolone group showed significantly reduced plasma IL-8 , TNFalpha , IL-1ra and TNFsr-2 whereas plasma IL-10 increased ."
],
"offsets": [
[
0,
156
]
]
}
]
| [
{
"id": "split_0_train_4464_entity",
"type": "progene_text",
"text": [
"IL-8"
],
"offsets": [
[
87,
91
]
],
"normalized": []
},
{
"id": "split_0_train_4465_entity",
"type": "progene_text",
"text": [
"TNFalpha"
],
"offsets": [
[
94,
102
]
],
"normalized": []
},
{
"id": "split_0_train_4466_entity",
"type": "progene_text",
"text": [
"IL-1ra"
],
"offsets": [
[
105,
111
]
],
"normalized": []
},
{
"id": "split_0_train_4467_entity",
"type": "progene_text",
"text": [
"TNFsr-2"
],
"offsets": [
[
116,
123
]
],
"normalized": []
},
{
"id": "split_0_train_4468_entity",
"type": "progene_text",
"text": [
"IL-10"
],
"offsets": [
[
139,
144
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2830 | split_0_train_2830 | [
{
"id": "split_0_train_2830_passage",
"type": "progene_text",
"text": [
"Compared to placebo , the methylprednisolone group demonstrated significantly reduced urinary NAG / creatinine ratio , TNFsr-2 and TGFbeta1 at 24 h whereas urinary alpha-1-microglobulin / creatinine ratios increased ."
],
"offsets": [
[
0,
217
]
]
}
]
| [
{
"id": "split_0_train_4469_entity",
"type": "progene_text",
"text": [
"TNFsr-2"
],
"offsets": [
[
119,
126
]
],
"normalized": []
},
{
"id": "split_0_train_4470_entity",
"type": "progene_text",
"text": [
"TGFbeta1"
],
"offsets": [
[
131,
139
]
],
"normalized": []
},
{
"id": "split_0_train_4471_entity",
"type": "progene_text",
"text": [
"alpha-1-microglobulin"
],
"offsets": [
[
164,
185
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2831 | split_0_train_2831 | [
{
"id": "split_0_train_2831_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2832 | split_0_train_2832 | [
{
"id": "split_0_train_2832_passage",
"type": "progene_text",
"text": [
"Methylprednisolone administration during cardiac surgery significantly reduces plasma and urinary TNFsr-2 and IL-1ra , urinary TGFbeta1 and subclinical renal injury but not dysfunction ."
],
"offsets": [
[
0,
186
]
]
}
]
| [
{
"id": "split_0_train_4472_entity",
"type": "progene_text",
"text": [
"TNFsr-2"
],
"offsets": [
[
98,
105
]
],
"normalized": []
},
{
"id": "split_0_train_4473_entity",
"type": "progene_text",
"text": [
"IL-1ra"
],
"offsets": [
[
110,
116
]
],
"normalized": []
},
{
"id": "split_0_train_4474_entity",
"type": "progene_text",
"text": [
"TGFbeta1"
],
"offsets": [
[
127,
135
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2833 | split_0_train_2833 | [
{
"id": "split_0_train_2833_passage",
"type": "progene_text",
"text": [
"The omptin family of enterobacterial surface proteases / adhesins : from housekeeping in Escherichia coli to systemic spread of Yersinia pestis ."
],
"offsets": [
[
0,
145
]
]
}
]
| [
{
"id": "split_0_train_4475_entity",
"type": "progene_text",
"text": [
"omptin family of enterobacterial surface proteases / adhesins"
],
"offsets": [
[
4,
65
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2834 | split_0_train_2834 | [
{
"id": "split_0_train_2834_passage",
"type": "progene_text",
"text": [
"The omptins are a family of enterobacterial surface proteases / adhesins that share high sequence identity and a conserved beta - barrel fold in the outer membrane ."
],
"offsets": [
[
0,
165
]
]
}
]
| [
{
"id": "split_0_train_4476_entity",
"type": "progene_text",
"text": [
"omptins"
],
"offsets": [
[
4,
11
]
],
"normalized": []
},
{
"id": "split_0_train_4477_entity",
"type": "progene_text",
"text": [
"family of enterobacterial surface proteases / adhesins"
],
"offsets": [
[
18,
72
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2835 | split_0_train_2835 | [
{
"id": "split_0_train_2835_passage",
"type": "progene_text",
"text": [
"The omptins are multifunctional , and the individual omptins exhibit differing virulence - associated functions ."
],
"offsets": [
[
0,
113
]
]
}
]
| [
{
"id": "split_0_train_4478_entity",
"type": "progene_text",
"text": [
"omptins"
],
"offsets": [
[
4,
11
]
],
"normalized": []
},
{
"id": "split_0_train_4479_entity",
"type": "progene_text",
"text": [
"omptins"
],
"offsets": [
[
53,
60
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2836 | split_0_train_2836 | [
{
"id": "split_0_train_2836_passage",
"type": "progene_text",
"text": [
"The Pla plasminogen activator of Yersinia pestis contributes by several mechanisms to bacterial invasiveness and the systemic , uncontrolled proteolysis in plague ."
],
"offsets": [
[
0,
164
]
]
}
]
| [
{
"id": "split_0_train_4480_entity",
"type": "progene_text",
"text": [
"Pla plasminogen activator"
],
"offsets": [
[
4,
29
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2837 | split_0_train_2837 | [
{
"id": "split_0_train_2837_passage",
"type": "progene_text",
"text": [
"Pla proteolytically activates the human proenzyme plasminogen and inactivates the antiprotease alpha2 - antiplasmin , and its binding to laminin localizes the uncontrolled plasmin activity onto basement membranes ."
],
"offsets": [
[
0,
214
]
]
}
]
| [
{
"id": "split_0_train_4481_entity",
"type": "progene_text",
"text": [
"Pla"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "split_0_train_4482_entity",
"type": "progene_text",
"text": [
"plasminogen"
],
"offsets": [
[
50,
61
]
],
"normalized": []
},
{
"id": "split_0_train_4483_entity",
"type": "progene_text",
"text": [
"alpha2 - antiplasmin"
],
"offsets": [
[
95,
115
]
],
"normalized": []
},
{
"id": "split_0_train_4484_entity",
"type": "progene_text",
"text": [
"laminin"
],
"offsets": [
[
137,
144
]
],
"normalized": []
},
{
"id": "split_0_train_4485_entity",
"type": "progene_text",
"text": [
"plasmin"
],
"offsets": [
[
172,
179
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2838 | split_0_train_2838 | [
{
"id": "split_0_train_2838_passage",
"type": "progene_text",
"text": [
"These properties enhance bacterial migration through tissue barriers ."
],
"offsets": [
[
0,
70
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2839 | split_0_train_2839 | [
{
"id": "split_0_train_2839_passage",
"type": "progene_text",
"text": [
"Pla also degrades circulating complement proteins and functions in bacterial invasion into human epithelial cells ."
],
"offsets": [
[
0,
115
]
]
}
]
| [
{
"id": "split_0_train_4486_entity",
"type": "progene_text",
"text": [
"Pla"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "split_0_train_4487_entity",
"type": "progene_text",
"text": [
"complement proteins"
],
"offsets": [
[
30,
49
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2840 | split_0_train_2840 | [
{
"id": "split_0_train_2840_passage",
"type": "progene_text",
"text": [
"PgtE of Salmonella enterica and OmpT of Escherichia coli have been shown to degrade cationic antimicrobial peptides from epithelial cells or macrophages ."
],
"offsets": [
[
0,
154
]
]
}
]
| [
{
"id": "split_0_train_4488_entity",
"type": "progene_text",
"text": [
"PgtE"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_4489_entity",
"type": "progene_text",
"text": [
"OmpT"
],
"offsets": [
[
32,
36
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2841 | split_0_train_2841 | [
{
"id": "split_0_train_2841_passage",
"type": "progene_text",
"text": [
"PgtE and SopA of Shigella flexneri appear important in the intracellular phases of salmonellosis and shigellosis , whereas functions of OmpT have mainly been associated with protein degradation in E. coli cells ."
],
"offsets": [
[
0,
212
]
]
}
]
| [
{
"id": "split_0_train_4490_entity",
"type": "progene_text",
"text": [
"PgtE"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_4491_entity",
"type": "progene_text",
"text": [
"SopA"
],
"offsets": [
[
9,
13
]
],
"normalized": []
},
{
"id": "split_0_train_4492_entity",
"type": "progene_text",
"text": [
"OmpT"
],
"offsets": [
[
136,
140
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2842 | split_0_train_2842 | [
{
"id": "split_0_train_2842_passage",
"type": "progene_text",
"text": [
"The differing virulence roles and functions have been attributed to minor sequence variations at the surface - exposed regions important for substrate recognition , to the dependence of omptin functions on lipopolysaccharide , and to the different regulation of omptin expression ."
],
"offsets": [
[
0,
281
]
]
}
]
| [
{
"id": "split_0_train_4493_entity",
"type": "progene_text",
"text": [
"omptin"
],
"offsets": [
[
186,
192
]
],
"normalized": []
},
{
"id": "split_0_train_4494_entity",
"type": "progene_text",
"text": [
"omptin"
],
"offsets": [
[
262,
268
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2843 | split_0_train_2843 | [
{
"id": "split_0_train_2843_passage",
"type": "progene_text",
"text": [
"alpha - thrombin rapidly induces tyrosine phosphorylation of a novel , 74 - 78 - kDa stress response protein ( s ) in lung fibroblast cells ."
],
"offsets": [
[
0,
141
]
]
}
]
| [
{
"id": "split_0_train_4495_entity",
"type": "progene_text",
"text": [
"alpha - thrombin"
],
"offsets": [
[
0,
16
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2844 | split_0_train_2844 | [
{
"id": "split_0_train_2844_passage",
"type": "progene_text",
"text": [
"We demonstrated previously that exposure of CCL39 lung fibroblasts to alpha-thrombin rapidly inhibits interleukin 6 - induced tyrosine phosphorylation of signal transducers and activators of transcription 3 ( Stat3 ) ."
],
"offsets": [
[
0,
218
]
]
}
]
| [
{
"id": "split_0_train_4496_entity",
"type": "progene_text",
"text": [
"alpha-thrombin"
],
"offsets": [
[
70,
84
]
],
"normalized": []
},
{
"id": "split_0_train_4497_entity",
"type": "progene_text",
"text": [
"interleukin 6"
],
"offsets": [
[
102,
115
]
],
"normalized": []
},
{
"id": "split_0_train_4498_entity",
"type": "progene_text",
"text": [
"signal transducers and activators of transcription 3"
],
"offsets": [
[
154,
206
]
],
"normalized": []
},
{
"id": "split_0_train_4499_entity",
"type": "progene_text",
"text": [
"Stat3"
],
"offsets": [
[
209,
214
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2845 | split_0_train_2845 | [
{
"id": "split_0_train_2845_passage",
"type": "progene_text",
"text": [
"While studying the cross - talk between alpha-thrombin and interleukin 6 , we observed that the phospho - specific ( tyrosine ) anti - Stat3 antibody specifically cross - reacted with a 74 - 78 - kDa protein ( s ) in alpha-thrombin - treated cells ."
],
"offsets": [
[
0,
249
]
]
}
]
| [
{
"id": "split_0_train_4500_entity",
"type": "progene_text",
"text": [
"alpha-thrombin"
],
"offsets": [
[
40,
54
]
],
"normalized": []
},
{
"id": "split_0_train_4501_entity",
"type": "progene_text",
"text": [
"interleukin 6"
],
"offsets": [
[
59,
72
]
],
"normalized": []
},
{
"id": "split_0_train_4502_entity",
"type": "progene_text",
"text": [
"Stat3"
],
"offsets": [
[
135,
140
]
],
"normalized": []
},
{
"id": "split_0_train_4503_entity",
"type": "progene_text",
"text": [
"alpha-thrombin"
],
"offsets": [
[
217,
231
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2846 | split_0_train_2846 | [
{
"id": "split_0_train_2846_passage",
"type": "progene_text",
"text": [
"In this study , we demonstrate that in alpha - thrombin - treated CCL39 cells , the 74 - 78 - kDa protein ( s ) rapidly undergoes tyrosine phosphorylation ."
],
"offsets": [
[
0,
156
]
]
}
]
| [
{
"id": "split_0_train_4504_entity",
"type": "progene_text",
"text": [
"alpha - thrombin"
],
"offsets": [
[
39,
55
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2847 | split_0_train_2847 | [
{
"id": "split_0_train_2847_passage",
"type": "progene_text",
"text": [
"The phosphorylation by alpha-thrombin was detected as early as 5 min and reached a maximum at 15 min ; however , low levels were present at 2 h ."
],
"offsets": [
[
0,
145
]
]
}
]
| [
{
"id": "split_0_train_4505_entity",
"type": "progene_text",
"text": [
"alpha-thrombin"
],
"offsets": [
[
23,
37
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2848 | split_0_train_2848 | [
{
"id": "split_0_train_2848_passage",
"type": "progene_text",
"text": [
"alpha-Thrombin receptor agonist peptide ( SFLLRN ) induced its tyrosine phosphorylation , suggesting that alpha - thrombin mediates the effects via protease - activated receptor type 1 ."
],
"offsets": [
[
0,
186
]
]
}
]
| [
{
"id": "split_0_train_4506_entity",
"type": "progene_text",
"text": [
"alpha-Thrombin receptor"
],
"offsets": [
[
0,
23
]
],
"normalized": []
},
{
"id": "split_0_train_4507_entity",
"type": "progene_text",
"text": [
"alpha - thrombin"
],
"offsets": [
[
106,
122
]
],
"normalized": []
},
{
"id": "split_0_train_4508_entity",
"type": "progene_text",
"text": [
"protease - activated receptor type 1"
],
"offsets": [
[
148,
184
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2849 | split_0_train_2849 | [
{
"id": "split_0_train_2849_passage",
"type": "progene_text",
"text": [
"Anti - Stat3 antibodies specific to different regions of Stat3 failed to recognize the 74-78-kDa protein(s) , suggesting that it is unrelated to Stat3 ."
],
"offsets": [
[
0,
152
]
]
}
]
| [
{
"id": "split_0_train_4509_entity",
"type": "progene_text",
"text": [
"Stat3"
],
"offsets": [
[
7,
12
]
],
"normalized": []
},
{
"id": "split_0_train_4510_entity",
"type": "progene_text",
"text": [
"Stat3"
],
"offsets": [
[
57,
62
]
],
"normalized": []
},
{
"id": "split_0_train_4511_entity",
"type": "progene_text",
"text": [
"Stat3"
],
"offsets": [
[
145,
150
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2850 | split_0_train_2850 | [
{
"id": "split_0_train_2850_passage",
"type": "progene_text",
"text": [
"Cell fractionation experiments showed that it is localized to the cytoplasm ."
],
"offsets": [
[
0,
77
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2851 | split_0_train_2851 | [
{
"id": "split_0_train_2851_passage",
"type": "progene_text",
"text": [
"Mass spectrometric analysis of the immunoprecipitated protein showed that the 74-78-kDa protein(s) is related to glucose - regulated protein 75 ( GRP - 75 ) , a member of the heat shock / stress - response protein family ."
],
"offsets": [
[
0,
222
]
]
}
]
| [
{
"id": "split_0_train_4512_entity",
"type": "progene_text",
"text": [
"glucose - regulated protein 75"
],
"offsets": [
[
113,
143
]
],
"normalized": []
},
{
"id": "split_0_train_4513_entity",
"type": "progene_text",
"text": [
"GRP - 75"
],
"offsets": [
[
146,
154
]
],
"normalized": []
},
{
"id": "split_0_train_4514_entity",
"type": "progene_text",
"text": [
"heat shock / stress - response protein family"
],
"offsets": [
[
175,
220
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2852 | split_0_train_2852 | [
{
"id": "split_0_train_2852_passage",
"type": "progene_text",
"text": [
"Consistent with these data , we observed tyrosine phosphorylation of GRP - 75 in alpha - thrombin - treated cells ."
],
"offsets": [
[
0,
115
]
]
}
]
| [
{
"id": "split_0_train_4515_entity",
"type": "progene_text",
"text": [
"GRP - 75"
],
"offsets": [
[
69,
77
]
],
"normalized": []
},
{
"id": "split_0_train_4516_entity",
"type": "progene_text",
"text": [
"alpha - thrombin"
],
"offsets": [
[
81,
97
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2853 | split_0_train_2853 | [
{
"id": "split_0_train_2853_passage",
"type": "progene_text",
"text": [
"Exposure of cells to pervanadate , a stress - inducing agent , stimulated its tyrosine phosphorylation ; however , cytokines and growth factors were ineffective ."
],
"offsets": [
[
0,
162
]
]
}
]
| [
{
"id": "split_0_train_4517_entity",
"type": "progene_text",
"text": [
"cytokines"
],
"offsets": [
[
115,
124
]
],
"normalized": []
},
{
"id": "split_0_train_4518_entity",
"type": "progene_text",
"text": [
"growth factors"
],
"offsets": [
[
129,
143
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2854 | split_0_train_2854 | [
{
"id": "split_0_train_2854_passage",
"type": "progene_text",
"text": [
"This is the first report of tyrosine phosphorylation of GRP-75 - related stress protein(s) by alpha - thrombin and suggests that this pathway may contribute to the ability of alpha - thrombin to prevent apoptosis in cells exposed to stress or in the injured tissue ."
],
"offsets": [
[
0,
266
]
]
}
]
| [
{
"id": "split_0_train_4519_entity",
"type": "progene_text",
"text": [
"GRP-75"
],
"offsets": [
[
56,
62
]
],
"normalized": []
},
{
"id": "split_0_train_4520_entity",
"type": "progene_text",
"text": [
"alpha - thrombin"
],
"offsets": [
[
94,
110
]
],
"normalized": []
},
{
"id": "split_0_train_4521_entity",
"type": "progene_text",
"text": [
"alpha - thrombin"
],
"offsets": [
[
175,
191
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2855 | split_0_train_2855 | [
{
"id": "split_0_train_2855_passage",
"type": "progene_text",
"text": [
"Characterization of EvgAS - YdeO - GadE branched regulatory circuit governing glutamate - dependent acid resistance in Escherichia coli ."
],
"offsets": [
[
0,
137
]
]
}
]
| [
{
"id": "split_0_train_4522_entity",
"type": "progene_text",
"text": [
"EvgAS"
],
"offsets": [
[
20,
25
]
],
"normalized": []
},
{
"id": "split_0_train_4523_entity",
"type": "progene_text",
"text": [
"YdeO"
],
"offsets": [
[
28,
32
]
],
"normalized": []
},
{
"id": "split_0_train_4524_entity",
"type": "progene_text",
"text": [
"GadE"
],
"offsets": [
[
35,
39
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2856 | split_0_train_2856 | [
{
"id": "split_0_train_2856_passage",
"type": "progene_text",
"text": [
"Escherichia coli prefers growth in neutral pH environments but can withstand extremely acidic conditions ( pH 2 ) for long periods ."
],
"offsets": [
[
0,
132
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2857 | split_0_train_2857 | [
{
"id": "split_0_train_2857_passage",
"type": "progene_text",
"text": [
"Of the four E. coli systems that contribute to acid resistance , one , the glutamate - dependent system , is remarkable in its efficacy and regulatory complexity ."
],
"offsets": [
[
0,
163
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2858 | split_0_train_2858 | [
{
"id": "split_0_train_2858_passage",
"type": "progene_text",
"text": [
"The resistance mechanism involves the intracellular consumption of protons by the glutamate decarboxylase isozymes GadA and GadB ."
],
"offsets": [
[
0,
130
]
]
}
]
| [
{
"id": "split_0_train_4525_entity",
"type": "progene_text",
"text": [
"glutamate decarboxylase"
],
"offsets": [
[
82,
105
]
],
"normalized": []
},
{
"id": "split_0_train_4526_entity",
"type": "progene_text",
"text": [
"GadA"
],
"offsets": [
[
115,
119
]
],
"normalized": []
},
{
"id": "split_0_train_4527_entity",
"type": "progene_text",
"text": [
"GadB"
],
"offsets": [
[
124,
128
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2859 | split_0_train_2859 | [
{
"id": "split_0_train_2859_passage",
"type": "progene_text",
"text": [
"The antiporter GadC then exports the product , gamma-aminobutyric acid , in exchange for fresh glutamate ."
],
"offsets": [
[
0,
106
]
]
}
]
| [
{
"id": "split_0_train_4528_entity",
"type": "progene_text",
"text": [
"antiporter"
],
"offsets": [
[
4,
14
]
],
"normalized": []
},
{
"id": "split_0_train_4529_entity",
"type": "progene_text",
"text": [
"GadC"
],
"offsets": [
[
15,
19
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2860 | split_0_train_2860 | [
{
"id": "split_0_train_2860_passage",
"type": "progene_text",
"text": [
"A microarray study using overexpressed regulators uncovered evgAS and ydeO as potential regulators of gadE , now known to encode the essential activator of the gadA and gadBC genes ."
],
"offsets": [
[
0,
182
]
]
}
]
| [
{
"id": "split_0_train_4530_entity",
"type": "progene_text",
"text": [
"evgAS"
],
"offsets": [
[
60,
65
]
],
"normalized": []
},
{
"id": "split_0_train_4531_entity",
"type": "progene_text",
"text": [
"ydeO"
],
"offsets": [
[
70,
74
]
],
"normalized": []
},
{
"id": "split_0_train_4532_entity",
"type": "progene_text",
"text": [
"gadE"
],
"offsets": [
[
102,
106
]
],
"normalized": []
},
{
"id": "split_0_train_4533_entity",
"type": "progene_text",
"text": [
"gadA"
],
"offsets": [
[
160,
164
]
],
"normalized": []
},
{
"id": "split_0_train_4534_entity",
"type": "progene_text",
"text": [
"gadBC"
],
"offsets": [
[
169,
174
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2861 | split_0_train_2861 | [
{
"id": "split_0_train_2861_passage",
"type": "progene_text",
"text": [
"Examination of evgA and ydeO under normal expression conditions revealed that their products do activate gadE expression but only under specific conditions ."
],
"offsets": [
[
0,
157
]
]
}
]
| [
{
"id": "split_0_train_4535_entity",
"type": "progene_text",
"text": [
"evgA"
],
"offsets": [
[
15,
19
]
],
"normalized": []
},
{
"id": "split_0_train_4536_entity",
"type": "progene_text",
"text": [
"ydeO"
],
"offsets": [
[
24,
28
]
],
"normalized": []
},
{
"id": "split_0_train_4537_entity",
"type": "progene_text",
"text": [
"gadE"
],
"offsets": [
[
105,
109
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2862 | split_0_train_2862 | [
{
"id": "split_0_train_2862_passage",
"type": "progene_text",
"text": [
"They were important during exponential growth in acidified minimal medium containing glucose but were unnecessary for gadE expression in stationary - phase cells grown in complex medium ."
],
"offsets": [
[
0,
187
]
]
}
]
| [
{
"id": "split_0_train_4538_entity",
"type": "progene_text",
"text": [
"gadE"
],
"offsets": [
[
118,
122
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2863 | split_0_train_2863 | [
{
"id": "split_0_train_2863_passage",
"type": "progene_text",
"text": [
"The response regulator EvgA activates gadE directly and indirectly via induction of the AraC - like regulator ydeO ."
],
"offsets": [
[
0,
116
]
]
}
]
| [
{
"id": "split_0_train_4539_entity",
"type": "progene_text",
"text": [
"EvgA"
],
"offsets": [
[
23,
27
]
],
"normalized": []
},
{
"id": "split_0_train_4540_entity",
"type": "progene_text",
"text": [
"gadE"
],
"offsets": [
[
38,
42
]
],
"normalized": []
},
{
"id": "split_0_train_4541_entity",
"type": "progene_text",
"text": [
"AraC"
],
"offsets": [
[
88,
92
]
],
"normalized": []
},
{
"id": "split_0_train_4542_entity",
"type": "progene_text",
"text": [
"ydeO"
],
"offsets": [
[
110,
114
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2864 | split_0_train_2864 | [
{
"id": "split_0_train_2864_passage",
"type": "progene_text",
"text": [
"Evidence obtained using gadE - lacZ operon fusions also revealed that GadE was autoinduced ."
],
"offsets": [
[
0,
92
]
]
}
]
| [
{
"id": "split_0_train_4543_entity",
"type": "progene_text",
"text": [
"gadE"
],
"offsets": [
[
24,
28
]
],
"normalized": []
},
{
"id": "split_0_train_4544_entity",
"type": "progene_text",
"text": [
"lacZ"
],
"offsets": [
[
31,
35
]
],
"normalized": []
},
{
"id": "split_0_train_4545_entity",
"type": "progene_text",
"text": [
"GadE"
],
"offsets": [
[
70,
74
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2865 | split_0_train_2865 | [
{
"id": "split_0_train_2865_passage",
"type": "progene_text",
"text": [
"Electrophoretic mobility shift assays indicated that EvgA , YdeO , and GadE bind to different regions upstream of gadE , indicating they all act directly at the gadE promoter ."
],
"offsets": [
[
0,
176
]
]
}
]
| [
{
"id": "split_0_train_4546_entity",
"type": "progene_text",
"text": [
"EvgA"
],
"offsets": [
[
53,
57
]
],
"normalized": []
},
{
"id": "split_0_train_4547_entity",
"type": "progene_text",
"text": [
"YdeO"
],
"offsets": [
[
60,
64
]
],
"normalized": []
},
{
"id": "split_0_train_4548_entity",
"type": "progene_text",
"text": [
"GadE"
],
"offsets": [
[
71,
75
]
],
"normalized": []
},
{
"id": "split_0_train_4549_entity",
"type": "progene_text",
"text": [
"gadE"
],
"offsets": [
[
114,
118
]
],
"normalized": []
},
{
"id": "split_0_train_4550_entity",
"type": "progene_text",
"text": [
"gadE"
],
"offsets": [
[
161,
165
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2866 | split_0_train_2866 | [
{
"id": "split_0_train_2866_passage",
"type": "progene_text",
"text": [
"Since GadE controls the expression of numerous genes besides gadA and gadBC , the relevance of these regulatory circuits extends beyond acid resistance ."
],
"offsets": [
[
0,
153
]
]
}
]
| [
{
"id": "split_0_train_4551_entity",
"type": "progene_text",
"text": [
"GadE"
],
"offsets": [
[
6,
10
]
],
"normalized": []
},
{
"id": "split_0_train_4552_entity",
"type": "progene_text",
"text": [
"gadA"
],
"offsets": [
[
61,
65
]
],
"normalized": []
},
{
"id": "split_0_train_4553_entity",
"type": "progene_text",
"text": [
"gadBC"
],
"offsets": [
[
70,
75
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2867 | split_0_train_2867 | [
{
"id": "split_0_train_2867_passage",
"type": "progene_text",
"text": [
"Estrogen upregulates renal angiotensin II AT1 and AT2 receptors in the rat ."
],
"offsets": [
[
0,
76
]
]
}
]
| [
{
"id": "split_0_train_4554_entity",
"type": "progene_text",
"text": [
"angiotensin II AT1 and AT2 receptors"
],
"offsets": [
[
27,
63
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2868 | split_0_train_2868 | [
{
"id": "split_0_train_2868_passage",
"type": "progene_text",
"text": [
"We studied renal AT1 and AT2 receptors in male , female , ovariectomized and ovariectomized - estrogen - treated Wistar - Hanover and Wistar - Kyoto rats ."
],
"offsets": [
[
0,
155
]
]
}
]
| [
{
"id": "split_0_train_4555_entity",
"type": "progene_text",
"text": [
"AT1 and AT2 receptors"
],
"offsets": [
[
17,
38
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2869 | split_0_train_2869 | [
{
"id": "split_0_train_2869_passage",
"type": "progene_text",
"text": [
"AT1 receptors and AT1A receptor mRNA predominated , with no significant differences between males and females ."
],
"offsets": [
[
0,
111
]
]
}
]
| [
{
"id": "split_0_train_4556_entity",
"type": "progene_text",
"text": [
"AT1 receptors"
],
"offsets": [
[
0,
13
]
],
"normalized": []
},
{
"id": "split_0_train_4557_entity",
"type": "progene_text",
"text": [
"AT1A receptor"
],
"offsets": [
[
18,
31
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2870 | split_0_train_2870 | [
{
"id": "split_0_train_2870_passage",
"type": "progene_text",
"text": [
"AT2 receptor expression was restricted in female rats to the capsule , the transition zone between outer and inner medulla , the endothelium lining the papilla , and arcuate arteries and veins ."
],
"offsets": [
[
0,
194
]
]
}
]
| [
{
"id": "split_0_train_4558_entity",
"type": "progene_text",
"text": [
"AT2 receptor"
],
"offsets": [
[
0,
12
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2871 | split_0_train_2871 | [
{
"id": "split_0_train_2871_passage",
"type": "progene_text",
"text": [
"There were no AT2 receptors in male rats , while male mice express substantial numbers of estrogen - dependent AT2 receptors ."
],
"offsets": [
[
0,
126
]
]
}
]
| [
{
"id": "split_0_train_4559_entity",
"type": "progene_text",
"text": [
"AT2 receptors"
],
"offsets": [
[
14,
27
]
],
"normalized": []
},
{
"id": "split_0_train_4560_entity",
"type": "progene_text",
"text": [
"AT2 receptors"
],
"offsets": [
[
111,
124
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2872 | split_0_train_2872 | [
{
"id": "split_0_train_2872_passage",
"type": "progene_text",
"text": [
"Arcuate arteries and veins expressed AT1B mRNA in males and females , and AT2 mRNA in females only ."
],
"offsets": [
[
0,
100
]
]
}
]
| [
{
"id": "split_0_train_4561_entity",
"type": "progene_text",
"text": [
"AT1B"
],
"offsets": [
[
37,
41
]
],
"normalized": []
},
{
"id": "split_0_train_4562_entity",
"type": "progene_text",
"text": [
"AT2"
],
"offsets": [
[
74,
77
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2873 | split_0_train_2873 | [
{
"id": "split_0_train_2873_passage",
"type": "progene_text",
"text": [
"AT1 receptor and AT2 receptor expression were estrogen - dependent , with increases in AT1 and AT2 receptor expression after estrogen treatment in ovariectomized rats ."
],
"offsets": [
[
0,
168
]
]
}
]
| [
{
"id": "split_0_train_4563_entity",
"type": "progene_text",
"text": [
"AT1 receptor"
],
"offsets": [
[
0,
12
]
],
"normalized": []
},
{
"id": "split_0_train_4564_entity",
"type": "progene_text",
"text": [
"AT2 receptor"
],
"offsets": [
[
17,
29
]
],
"normalized": []
},
{
"id": "split_0_train_4565_entity",
"type": "progene_text",
"text": [
"AT1 and AT2 receptor"
],
"offsets": [
[
87,
107
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2874 | split_0_train_2874 | [
{
"id": "split_0_train_2874_passage",
"type": "progene_text",
"text": [
"Estrogen treatment increased prostaglandin E2 ( PGE2 ) and cGMP concentrations in the renal medulla , and eNOS expression in cortical arteries ."
],
"offsets": [
[
0,
144
]
]
}
]
| [
{
"id": "split_0_train_4566_entity",
"type": "progene_text",
"text": [
"eNOS"
],
"offsets": [
[
106,
110
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2875 | split_0_train_2875 | [
{
"id": "split_0_train_2875_passage",
"type": "progene_text",
"text": [
"In rodents , expression of renal Angiotensin II receptor types is estrogen - dependent , with significant species , strain and area differences ."
],
"offsets": [
[
0,
145
]
]
}
]
| [
{
"id": "split_0_train_4567_entity",
"type": "progene_text",
"text": [
"Angiotensin II receptor"
],
"offsets": [
[
33,
56
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2876 | split_0_train_2876 | [
{
"id": "split_0_train_2876_passage",
"type": "progene_text",
"text": [
"Our results support an important role for AT2 receptors in the regulation of renal function and in the protective effects of estrogen in the kidney ."
],
"offsets": [
[
0,
149
]
]
}
]
| [
{
"id": "split_0_train_4568_entity",
"type": "progene_text",
"text": [
"AT2 receptors"
],
"offsets": [
[
42,
55
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2877 | split_0_train_2877 | [
{
"id": "split_0_train_2877_passage",
"type": "progene_text",
"text": [
"The silent KIR3DP1 gene ( CD158c ) is transcribed and might encode a secreted receptor in a minority of humans , in whom the KIR3DP1 , KIR2DL4 and KIR3DL1 / KIR3DS1 genes are duplicated ."
],
"offsets": [
[
0,
187
]
]
}
]
| [
{
"id": "split_0_train_4569_entity",
"type": "progene_text",
"text": [
"KIR3DP1"
],
"offsets": [
[
11,
18
]
],
"normalized": []
},
{
"id": "split_0_train_4570_entity",
"type": "progene_text",
"text": [
"CD158c"
],
"offsets": [
[
26,
32
]
],
"normalized": []
},
{
"id": "split_0_train_4571_entity",
"type": "progene_text",
"text": [
"KIR3DP1"
],
"offsets": [
[
125,
132
]
],
"normalized": []
},
{
"id": "split_0_train_4572_entity",
"type": "progene_text",
"text": [
"KIR2DL4"
],
"offsets": [
[
135,
142
]
],
"normalized": []
},
{
"id": "split_0_train_4573_entity",
"type": "progene_text",
"text": [
"KIR3DL1"
],
"offsets": [
[
147,
154
]
],
"normalized": []
},
{
"id": "split_0_train_4574_entity",
"type": "progene_text",
"text": [
"KIR3DS1"
],
"offsets": [
[
157,
164
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2878 | split_0_train_2878 | [
{
"id": "split_0_train_2878_passage",
"type": "progene_text",
"text": [
"Killer - cell Ig - like receptors ( KIR ) are structurally and functionally diverse , and enable human NK cells to survey the expression of individual HLA class I molecules , often altered in infections and tumors ."
],
"offsets": [
[
0,
215
]
]
}
]
| [
{
"id": "split_0_train_4575_entity",
"type": "progene_text",
"text": [
"Killer - cell Ig - like receptors"
],
"offsets": [
[
0,
33
]
],
"normalized": []
},
{
"id": "split_0_train_4576_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
36,
39
]
],
"normalized": []
},
{
"id": "split_0_train_4577_entity",
"type": "progene_text",
"text": [
"HLA class I"
],
"offsets": [
[
151,
162
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2879 | split_0_train_2879 | [
{
"id": "split_0_train_2879_passage",
"type": "progene_text",
"text": [
"Multiple events of non - reciprocal recombination have contributed to the rapid diversification of KIR ."
],
"offsets": [
[
0,
104
]
]
}
]
| [
{
"id": "split_0_train_4578_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
99,
102
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2880 | split_0_train_2880 | [
{
"id": "split_0_train_2880_passage",
"type": "progene_text",
"text": [
"We show that approximately 4.5 % of the individuals of a Caucasoid population bear a recombinant allele of KIR3DP1 , officially designed KIR3DP1*004 , that associates tightly with gene duplications of KIR3DP1 , KIR2DL4 and KIR3DL1 / KIR3DS1 ."
],
"offsets": [
[
0,
242
]
]
}
]
| [
{
"id": "split_0_train_4579_entity",
"type": "progene_text",
"text": [
"KIR3DP1"
],
"offsets": [
[
107,
114
]
],
"normalized": []
},
{
"id": "split_0_train_4580_entity",
"type": "progene_text",
"text": [
"KIR3DP1*004"
],
"offsets": [
[
137,
148
]
],
"normalized": []
},
{
"id": "split_0_train_4581_entity",
"type": "progene_text",
"text": [
"KIR3DP1"
],
"offsets": [
[
201,
208
]
],
"normalized": []
},
{
"id": "split_0_train_4582_entity",
"type": "progene_text",
"text": [
"KIR2DL4"
],
"offsets": [
[
211,
218
]
],
"normalized": []
},
{
"id": "split_0_train_4583_entity",
"type": "progene_text",
"text": [
"KIR3DL1"
],
"offsets": [
[
223,
230
]
],
"normalized": []
},
{
"id": "split_0_train_4584_entity",
"type": "progene_text",
"text": [
"KIR3DS1"
],
"offsets": [
[
233,
240
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2881 | split_0_train_2881 | [
{
"id": "split_0_train_2881_passage",
"type": "progene_text",
"text": [
"The KIR3DP1 gene is normally silent , but the recombinant allele carries a novel promoter sequence and , as a consequence , is transcribed in all tested individuals ."
],
"offsets": [
[
0,
166
]
]
}
]
| [
{
"id": "split_0_train_4585_entity",
"type": "progene_text",
"text": [
"KIR3DP1"
],
"offsets": [
[
4,
11
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2882 | split_0_train_2882 | [
{
"id": "split_0_train_2882_passage",
"type": "progene_text",
"text": [
"Messenger RNA of KIR3DP1*004 is made up of six exons ; of these , exons 1 - 5 are similar to , and spliced like , those encoding the leader peptide and Ig - domains of KIR3D ."
],
"offsets": [
[
0,
175
]
]
}
]
| [
{
"id": "split_0_train_4586_entity",
"type": "progene_text",
"text": [
"KIR3DP1*004"
],
"offsets": [
[
17,
28
]
],
"normalized": []
},
{
"id": "split_0_train_4587_entity",
"type": "progene_text",
"text": [
"Ig"
],
"offsets": [
[
152,
154
]
],
"normalized": []
},
{
"id": "split_0_train_4588_entity",
"type": "progene_text",
"text": [
"KIR3D"
],
"offsets": [
[
168,
173
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2883 | split_0_train_2883 | [
{
"id": "split_0_train_2883_passage",
"type": "progene_text",
"text": [
"By contrast , exon 6 is homologous to no other human KIR sequence , but only to possible homologs in chimpanzees and rhesus macaques , and encodes a short hydrophilic tail ."
],
"offsets": [
[
0,
173
]
]
}
]
| [
{
"id": "split_0_train_4589_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
53,
56
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2884 | split_0_train_2884 | [
{
"id": "split_0_train_2884_passage",
"type": "progene_text",
"text": [
"The putative KIR3DP1*004 product , like those of the related genes LAIR-2 and LILRA3 / ILT6 / LIR4 , is predicted to be secreted to the extracellular medium rather than anchored to the cell membrane ."
],
"offsets": [
[
0,
200
]
]
}
]
| [
{
"id": "split_0_train_4590_entity",
"type": "progene_text",
"text": [
"KIR3DP1*004"
],
"offsets": [
[
13,
24
]
],
"normalized": []
},
{
"id": "split_0_train_4591_entity",
"type": "progene_text",
"text": [
"LAIR-2"
],
"offsets": [
[
67,
73
]
],
"normalized": []
},
{
"id": "split_0_train_4592_entity",
"type": "progene_text",
"text": [
"LILRA3"
],
"offsets": [
[
78,
84
]
],
"normalized": []
},
{
"id": "split_0_train_4593_entity",
"type": "progene_text",
"text": [
"ILT6"
],
"offsets": [
[
87,
91
]
],
"normalized": []
},
{
"id": "split_0_train_4594_entity",
"type": "progene_text",
"text": [
"LIR4"
],
"offsets": [
[
94,
98
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2885 | split_0_train_2885 | [
{
"id": "split_0_train_2885_passage",
"type": "progene_text",
"text": [
"Escherichia coli dihydroxyacetone kinase controls gene expression by binding to transcription factor DhaR ."
],
"offsets": [
[
0,
107
]
]
}
]
| [
{
"id": "split_0_train_4595_entity",
"type": "progene_text",
"text": [
"dihydroxyacetone kinase"
],
"offsets": [
[
17,
40
]
],
"normalized": []
},
{
"id": "split_0_train_4596_entity",
"type": "progene_text",
"text": [
"transcription factor"
],
"offsets": [
[
80,
100
]
],
"normalized": []
},
{
"id": "split_0_train_4597_entity",
"type": "progene_text",
"text": [
"DhaR"
],
"offsets": [
[
101,
105
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2886 | split_0_train_2886 | [
{
"id": "split_0_train_2886_passage",
"type": "progene_text",
"text": [
"Dihydroxyacetone ( Dha ) kinases are a sequence - conserved family of enzymes , which utilize either ATP ( in animals , plants , bacteria ) or the bacterial phosphoenolpyruvate carbohydrate phosphotransferase system ( PTS ) as a source of high - energy phosphate ."
],
"offsets": [
[
0,
264
]
]
}
]
| [
{
"id": "split_0_train_4598_entity",
"type": "progene_text",
"text": [
"Dihydroxyacetone ( Dha ) kinases"
],
"offsets": [
[
0,
32
]
],
"normalized": []
},
{
"id": "split_0_train_4599_entity",
"type": "progene_text",
"text": [
"phosphoenolpyruvate carbohydrate phosphotransferase"
],
"offsets": [
[
157,
208
]
],
"normalized": []
},
{
"id": "split_0_train_4600_entity",
"type": "progene_text",
"text": [
"PTS"
],
"offsets": [
[
218,
221
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2887 | split_0_train_2887 | [
{
"id": "split_0_train_2887_passage",
"type": "progene_text",
"text": [
"The PTS - dependent kinase of Escherichia coli consists of three subunits : DhaK contains the Dha binding site , DhaL contains ADP as cofactor for the double displacement of phosphate from DhaM to Dha , and DhaM provides a phospho - histidine relay between the PTS and DhaL : : ADP ."
],
"offsets": [
[
0,
283
]
]
}
]
| [
{
"id": "split_0_train_4601_entity",
"type": "progene_text",
"text": [
"PTS - dependent kinase"
],
"offsets": [
[
4,
26
]
],
"normalized": []
},
{
"id": "split_0_train_4602_entity",
"type": "progene_text",
"text": [
"DhaK"
],
"offsets": [
[
76,
80
]
],
"normalized": []
},
{
"id": "split_0_train_4603_entity",
"type": "progene_text",
"text": [
"DhaL"
],
"offsets": [
[
113,
117
]
],
"normalized": []
},
{
"id": "split_0_train_4604_entity",
"type": "progene_text",
"text": [
"DhaM"
],
"offsets": [
[
189,
193
]
],
"normalized": []
},
{
"id": "split_0_train_4605_entity",
"type": "progene_text",
"text": [
"DhaM"
],
"offsets": [
[
207,
211
]
],
"normalized": []
},
{
"id": "split_0_train_4606_entity",
"type": "progene_text",
"text": [
"PTS"
],
"offsets": [
[
261,
264
]
],
"normalized": []
},
{
"id": "split_0_train_4607_entity",
"type": "progene_text",
"text": [
"DhaL"
],
"offsets": [
[
269,
273
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2888 | split_0_train_2888 | [
{
"id": "split_0_train_2888_passage",
"type": "progene_text",
"text": [
"DhaR is a transcription activator belonging to the AAA + family of enhancer binding proteins ."
],
"offsets": [
[
0,
94
]
]
}
]
| [
{
"id": "split_0_train_4608_entity",
"type": "progene_text",
"text": [
"DhaR"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_4609_entity",
"type": "progene_text",
"text": [
"AAA + family"
],
"offsets": [
[
51,
63
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2889 | split_0_train_2889 | [
{
"id": "split_0_train_2889_passage",
"type": "progene_text",
"text": [
"It stimulates transcription of the dhaKLM operon from a sigma70 promoter and autorepresses dhaR transcription ."
],
"offsets": [
[
0,
111
]
]
}
]
| [
{
"id": "split_0_train_4610_entity",
"type": "progene_text",
"text": [
"dhaKLM operon"
],
"offsets": [
[
35,
48
]
],
"normalized": []
},
{
"id": "split_0_train_4611_entity",
"type": "progene_text",
"text": [
"sigma70"
],
"offsets": [
[
56,
63
]
],
"normalized": []
},
{
"id": "split_0_train_4612_entity",
"type": "progene_text",
"text": [
"dhaR"
],
"offsets": [
[
91,
95
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2890 | split_0_train_2890 | [
{
"id": "split_0_train_2890_passage",
"type": "progene_text",
"text": [
"Genetic and biochemical studies indicate that the enzyme subunits DhaL and DhaK act antagonistically as coactivator and corepressor of the transcription activator by mutually exclusive binding to the sensing domain of DhaR ."
],
"offsets": [
[
0,
224
]
]
}
]
| [
{
"id": "split_0_train_4613_entity",
"type": "progene_text",
"text": [
"DhaL"
],
"offsets": [
[
66,
70
]
],
"normalized": []
},
{
"id": "split_0_train_4614_entity",
"type": "progene_text",
"text": [
"DhaK"
],
"offsets": [
[
75,
79
]
],
"normalized": []
},
{
"id": "split_0_train_4615_entity",
"type": "progene_text",
"text": [
"DhaR"
],
"offsets": [
[
218,
222
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2891 | split_0_train_2891 | [
{
"id": "split_0_train_2891_passage",
"type": "progene_text",
"text": [
"In the presence of Dha , DhaL is dephosphorylated and DhaL : : ADP displaces DhaK and stimulates DhaR activity ."
],
"offsets": [
[
0,
112
]
]
}
]
| [
{
"id": "split_0_train_4616_entity",
"type": "progene_text",
"text": [
"DhaL"
],
"offsets": [
[
25,
29
]
],
"normalized": []
},
{
"id": "split_0_train_4617_entity",
"type": "progene_text",
"text": [
"DhaL"
],
"offsets": [
[
54,
58
]
],
"normalized": []
},
{
"id": "split_0_train_4618_entity",
"type": "progene_text",
"text": [
"DhaK"
],
"offsets": [
[
77,
81
]
],
"normalized": []
},
{
"id": "split_0_train_4619_entity",
"type": "progene_text",
"text": [
"DhaR"
],
"offsets": [
[
97,
101
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2892 | split_0_train_2892 | [
{
"id": "split_0_train_2892_passage",
"type": "progene_text",
"text": [
"In the absence of Dha , DhaL : : ADP is converted by the PTS to DhaL : : ATP , which does not bind to DhaR ."
],
"offsets": [
[
0,
108
]
]
}
]
| [
{
"id": "split_0_train_4620_entity",
"type": "progene_text",
"text": [
"DhaL"
],
"offsets": [
[
24,
28
]
],
"normalized": []
},
{
"id": "split_0_train_4621_entity",
"type": "progene_text",
"text": [
"PTS"
],
"offsets": [
[
57,
60
]
],
"normalized": []
},
{
"id": "split_0_train_4622_entity",
"type": "progene_text",
"text": [
"DhaL"
],
"offsets": [
[
64,
68
]
],
"normalized": []
},
{
"id": "split_0_train_4623_entity",
"type": "progene_text",
"text": [
"DhaR"
],
"offsets": [
[
102,
106
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2893 | split_0_train_2893 | [
{
"id": "split_0_train_2893_passage",
"type": "progene_text",
"text": [
"Asymmetric localization of seed storage protein RNAs to distinct subdomains of the endoplasmic reticulum in developing maize endosperm cells ."
],
"offsets": [
[
0,
142
]
]
}
]
| [
{
"id": "split_0_train_4624_entity",
"type": "progene_text",
"text": [
"seed storage protein"
],
"offsets": [
[
27,
47
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2894 | split_0_train_2894 | [
{
"id": "split_0_train_2894_passage",
"type": "progene_text",
"text": [
"Plant storage proteins are synthesized and stored in different compartments of the plant endomembrane system ."
],
"offsets": [
[
0,
110
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2895 | split_0_train_2895 | [
{
"id": "split_0_train_2895_passage",
"type": "progene_text",
"text": [
"Developing maize seeds synthesize and accumulate prolamin ( zein ) and 11S globulin ( legumin-1 ) type proteins , which are sequestered in the endoplasmic reticulum ( ER ) lumen and storage vacuoles , respectively ."
],
"offsets": [
[
0,
215
]
]
}
]
| [
{
"id": "split_0_train_4625_entity",
"type": "progene_text",
"text": [
"prolamin"
],
"offsets": [
[
49,
57
]
],
"normalized": []
},
{
"id": "split_0_train_4626_entity",
"type": "progene_text",
"text": [
"zein"
],
"offsets": [
[
60,
64
]
],
"normalized": []
},
{
"id": "split_0_train_4627_entity",
"type": "progene_text",
"text": [
"11S globulin"
],
"offsets": [
[
71,
83
]
],
"normalized": []
},
{
"id": "split_0_train_4628_entity",
"type": "progene_text",
"text": [
"legumin-1"
],
"offsets": [
[
86,
95
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2896 | split_0_train_2896 | [
{
"id": "split_0_train_2896_passage",
"type": "progene_text",
"text": [
"Immunofluorescence studies showed that the lumenal chaperone BiP was not randomly distributed within the ER in developing maize endosperm but concentrated within the zein - containing protein bodies ."
],
"offsets": [
[
0,
200
]
]
}
]
| [
{
"id": "split_0_train_4629_entity",
"type": "progene_text",
"text": [
"BiP"
],
"offsets": [
[
61,
64
]
],
"normalized": []
},
{
"id": "split_0_train_4630_entity",
"type": "progene_text",
"text": [
"zein"
],
"offsets": [
[
166,
170
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2897 | split_0_train_2897 | [
{
"id": "split_0_train_2897_passage",
"type": "progene_text",
"text": [
"Analysis of the spatial distribution of RNAs in maize endosperm sections by in situ RT - PCR showed that , contrary to the conclusions made in an earlier study [ Kim et al. ( 2002 ) Plant Cell 14 : 655-672 ] , the zein and legumin-1 RNAs are not symmetrically distributed on the ER but , instead , targeted to specific ER subdomains ."
],
"offsets": [
[
0,
334
]
]
}
]
| [
{
"id": "split_0_train_4631_entity",
"type": "progene_text",
"text": [
"zein"
],
"offsets": [
[
214,
218
]
],
"normalized": []
},
{
"id": "split_0_train_4632_entity",
"type": "progene_text",
"text": [
"legumin-1"
],
"offsets": [
[
223,
232
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2898 | split_0_train_2898 | [
{
"id": "split_0_train_2898_passage",
"type": "progene_text",
"text": [
"RNAs coding for 22 kDa alpha-zein , 15 kDa beta-zein , 27 kDa gamma - zein and 10 kDa delta-zein were localized to ER - bounded zein protein bodies , whereas 51 kDa legumin-1 RNAs were distributed on adjacent cisternal ER proximal to the zein protein bodies ."
],
"offsets": [
[
0,
259
]
]
}
]
| [
{
"id": "split_0_train_4633_entity",
"type": "progene_text",
"text": [
"alpha-zein"
],
"offsets": [
[
23,
33
]
],
"normalized": []
},
{
"id": "split_0_train_4634_entity",
"type": "progene_text",
"text": [
"beta-zein"
],
"offsets": [
[
43,
52
]
],
"normalized": []
},
{
"id": "split_0_train_4635_entity",
"type": "progene_text",
"text": [
"gamma - zein"
],
"offsets": [
[
62,
74
]
],
"normalized": []
},
{
"id": "split_0_train_4636_entity",
"type": "progene_text",
"text": [
"delta-zein"
],
"offsets": [
[
86,
96
]
],
"normalized": []
},
{
"id": "split_0_train_4637_entity",
"type": "progene_text",
"text": [
"zein"
],
"offsets": [
[
128,
132
]
],
"normalized": []
},
{
"id": "split_0_train_4638_entity",
"type": "progene_text",
"text": [
"legumin-1"
],
"offsets": [
[
165,
174
]
],
"normalized": []
},
{
"id": "split_0_train_4639_entity",
"type": "progene_text",
"text": [
"zein"
],
"offsets": [
[
238,
242
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2899 | split_0_train_2899 | [
{
"id": "split_0_train_2899_passage",
"type": "progene_text",
"text": [
"These results indicate that the maize storage protein RNAs are targeted to specific ER subdomains in developing maize endosperm and that RNA localization may be a prevalent mechanism to sort proteins within plant cells ."
],
"offsets": [
[
0,
220
]
]
}
]
| []
| []
| []
| []
|
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