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stringlengths 15
19
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stringlengths 15
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| passages
list | entities
list | events
list | coreferences
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|---|---|---|---|---|---|---|
split_0_train_2900 | split_0_train_2900 | [
{
"id": "split_0_train_2900_passage",
"type": "progene_text",
"text": [
"Promoter elements required for positive control of transcription of the Escherichia coli uhpT gene ."
],
"offsets": [
[
0,
100
]
]
}
]
| [
{
"id": "split_0_train_4640_entity",
"type": "progene_text",
"text": [
"uhpT"
],
"offsets": [
[
89,
93
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2901 | split_0_train_2901 | [
{
"id": "split_0_train_2901_passage",
"type": "progene_text",
"text": [
"The uhpABCT locus of Escherichia coli encodes the transport system which allows the cell to accumulate a variety of sugar phosphates in unaltered form ."
],
"offsets": [
[
0,
152
]
]
}
]
| [
{
"id": "split_0_train_4641_entity",
"type": "progene_text",
"text": [
"uhpABCT"
],
"offsets": [
[
4,
11
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2902 | split_0_train_2902 | [
{
"id": "split_0_train_2902_passage",
"type": "progene_text",
"text": [
"The expression of uhpT , the gene encoding the transport protein , is regulated by the uhpABC gene products ."
],
"offsets": [
[
0,
109
]
]
}
]
| [
{
"id": "split_0_train_4642_entity",
"type": "progene_text",
"text": [
"uhpT"
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"offsets": [
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18,
22
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"normalized": []
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{
"id": "split_0_train_4643_entity",
"type": "progene_text",
"text": [
"uhpABC"
],
"offsets": [
[
87,
93
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2903 | split_0_train_2903 | [
{
"id": "split_0_train_2903_passage",
"type": "progene_text",
"text": [
"The UhpA protein is required for expression ; its deduced amino acid sequence shows that it belongs to a subfamily of bacterial transcription regulators including NarL , DegU , and FixJ ."
],
"offsets": [
[
0,
187
]
]
}
]
| [
{
"id": "split_0_train_4644_entity",
"type": "progene_text",
"text": [
"UhpA"
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4,
8
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{
"id": "split_0_train_4645_entity",
"type": "progene_text",
"text": [
"NarL"
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163,
167
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"normalized": []
},
{
"id": "split_0_train_4646_entity",
"type": "progene_text",
"text": [
"DegU"
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170,
174
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"normalized": []
},
{
"id": "split_0_train_4647_entity",
"type": "progene_text",
"text": [
"FixJ"
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"offsets": [
[
181,
185
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2904 | split_0_train_2904 | [
{
"id": "split_0_train_2904_passage",
"type": "progene_text",
"text": [
"Members of this subfamily have an amino - terminal phosphorylation domain characteristic of so - called two - component regulators , such as OmpR , CheY , PhoB , and NtrC , and a carboxyl - terminal domain conserved among many transcriptional activators , including LuxR and MalT ."
],
"offsets": [
[
0,
281
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]
}
]
| [
{
"id": "split_0_train_4648_entity",
"type": "progene_text",
"text": [
"OmpR"
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"offsets": [
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141,
145
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{
"id": "split_0_train_4649_entity",
"type": "progene_text",
"text": [
"CheY"
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[
148,
152
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{
"id": "split_0_train_4650_entity",
"type": "progene_text",
"text": [
"PhoB"
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[
155,
159
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"normalized": []
},
{
"id": "split_0_train_4651_entity",
"type": "progene_text",
"text": [
"NtrC"
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166,
170
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"normalized": []
},
{
"id": "split_0_train_4652_entity",
"type": "progene_text",
"text": [
"LuxR"
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"offsets": [
[
266,
270
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],
"normalized": []
},
{
"id": "split_0_train_4653_entity",
"type": "progene_text",
"text": [
"MalT"
],
"offsets": [
[
275,
279
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2905 | split_0_train_2905 | [
{
"id": "split_0_train_2905_passage",
"type": "progene_text",
"text": [
"The major sequence elements in the uhpT promoter that are needed for uhpT expression were investigated ."
],
"offsets": [
[
0,
104
]
]
}
]
| [
{
"id": "split_0_train_4654_entity",
"type": "progene_text",
"text": [
"uhpT"
],
"offsets": [
[
35,
39
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],
"normalized": []
},
{
"id": "split_0_train_4655_entity",
"type": "progene_text",
"text": [
"uhpT"
],
"offsets": [
[
69,
73
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2906 | split_0_train_2906 | [
{
"id": "split_0_train_2906_passage",
"type": "progene_text",
"text": [
"Northern ( RNA ) hybridization analysis showed that the uhpT transcript was only present in cells induced for UhpT transport activity ."
],
"offsets": [
[
0,
135
]
]
}
]
| [
{
"id": "split_0_train_4656_entity",
"type": "progene_text",
"text": [
"uhpT"
],
"offsets": [
[
56,
60
]
],
"normalized": []
},
{
"id": "split_0_train_4657_entity",
"type": "progene_text",
"text": [
"UhpT"
],
"offsets": [
[
110,
114
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2907 | split_0_train_2907 | [
{
"id": "split_0_train_2907_passage",
"type": "progene_text",
"text": [
"The start site of transcription was identified by primer extension ."
],
"offsets": [
[
0,
68
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2908 | split_0_train_2908 | [
{
"id": "split_0_train_2908_passage",
"type": "progene_text",
"text": [
"Comparison of the regions upstream of the uhpT transcription start site in E. coli and Salmonella typhimurium suggested the presence of four sequence elements that might be involved in promoter function : a typical - 10 region , a short inverted repeat centered at - 32 , a long inverted repeat centered at - 64 , and a cyclic AMP receptor protein - binding sequence centered at - 103 ."
],
"offsets": [
[
0,
386
]
]
}
]
| [
{
"id": "split_0_train_4658_entity",
"type": "progene_text",
"text": [
"uhpT"
],
"offsets": [
[
42,
46
]
],
"normalized": []
},
{
"id": "split_0_train_4659_entity",
"type": "progene_text",
"text": [
"cyclic AMP receptor protein"
],
"offsets": [
[
320,
347
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2909 | split_0_train_2909 | [
{
"id": "split_0_train_2909_passage",
"type": "progene_text",
"text": [
"Deletion and linker substitution mutations in the promoter demonstrated that the presence of the cyclic AMP receptor protein - binding site resulted in about an eightfold increase in promoter activity and that the - 64 , - 32 , and - 10 elements were essential for promoter function ."
],
"offsets": [
[
0,
284
]
]
}
]
| [
{
"id": "split_0_train_4660_entity",
"type": "progene_text",
"text": [
"cyclic AMP receptor protein"
],
"offsets": [
[
97,
124
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2910 | split_0_train_2910 | [
{
"id": "split_0_train_2910_passage",
"type": "progene_text",
"text": [
"In vivo titration of transcriptional activator UhpA by the intact or mutant promoters on multicopy plasmids identified the - 64 element as the UhpA - binding site ."
],
"offsets": [
[
0,
164
]
]
}
]
| [
{
"id": "split_0_train_4661_entity",
"type": "progene_text",
"text": [
"UhpA"
],
"offsets": [
[
47,
51
]
],
"normalized": []
},
{
"id": "split_0_train_4662_entity",
"type": "progene_text",
"text": [
"UhpA"
],
"offsets": [
[
143,
147
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2911 | split_0_train_2911 | [
{
"id": "split_0_train_2911_passage",
"type": "progene_text",
"text": [
"The two halves of the - 64 inverted repeat did not contribute equally to promoter function and did not have to be intact for UhpA titration ."
],
"offsets": [
[
0,
141
]
]
}
]
| [
{
"id": "split_0_train_4663_entity",
"type": "progene_text",
"text": [
"UhpA"
],
"offsets": [
[
125,
129
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2912 | split_0_train_2912 | [
{
"id": "split_0_train_2912_passage",
"type": "progene_text",
"text": [
"The sequence recognized by UhpA is predicted to be 5' - GGCAAAACNNNGAAA ."
],
"offsets": [
[
0,
73
]
]
}
]
| [
{
"id": "split_0_train_4664_entity",
"type": "progene_text",
"text": [
"UhpA"
],
"offsets": [
[
27,
31
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2913 | split_0_train_2913 | [
{
"id": "split_0_train_2913_passage",
"type": "progene_text",
"text": [
"The interleukin-1 - related cytokine IL-1F8 is expressed in glial cells , but fails to induce IL-1beta signalling responses ."
],
"offsets": [
[
0,
125
]
]
}
]
| [
{
"id": "split_0_train_4665_entity",
"type": "progene_text",
"text": [
"interleukin-1"
],
"offsets": [
[
4,
17
]
],
"normalized": []
},
{
"id": "split_0_train_4666_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
28,
36
]
],
"normalized": []
},
{
"id": "split_0_train_4667_entity",
"type": "progene_text",
"text": [
"IL-1F8"
],
"offsets": [
[
37,
43
]
],
"normalized": []
},
{
"id": "split_0_train_4668_entity",
"type": "progene_text",
"text": [
"IL-1beta"
],
"offsets": [
[
94,
102
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2914 | split_0_train_2914 | [
{
"id": "split_0_train_2914_passage",
"type": "progene_text",
"text": [
"The putative new interleukin ( IL ) - 1 family member IL-1F8 ( IL-1eta , IL-1H2 ) has been shown recently to activate mitogen activated protein kinases ( MAPKs ) , extracellular signal - regulated protein kinase ( ERK1 / 2 ) and c-Jun N - terminal kinase ( JNK ) , and nuclear factor - kappa B ( NFkappa B ) via a mechanism that requires IL-1Rrp2 expression in cell lines ."
],
"offsets": [
[
0,
373
]
]
}
]
| [
{
"id": "split_0_train_4669_entity",
"type": "progene_text",
"text": [
"interleukin ( IL ) - 1 family"
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"offsets": [
[
17,
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},
{
"id": "split_0_train_4670_entity",
"type": "progene_text",
"text": [
"IL-1F8"
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[
54,
60
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{
"id": "split_0_train_4671_entity",
"type": "progene_text",
"text": [
"IL-1eta"
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63,
70
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{
"id": "split_0_train_4672_entity",
"type": "progene_text",
"text": [
"IL-1H2"
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[
73,
79
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{
"id": "split_0_train_4673_entity",
"type": "progene_text",
"text": [
"mitogen activated protein kinases"
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118,
151
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],
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},
{
"id": "split_0_train_4674_entity",
"type": "progene_text",
"text": [
"MAPKs"
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"offsets": [
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154,
159
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],
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},
{
"id": "split_0_train_4675_entity",
"type": "progene_text",
"text": [
"extracellular signal - regulated protein kinase"
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164,
211
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],
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},
{
"id": "split_0_train_4676_entity",
"type": "progene_text",
"text": [
"ERK1 / 2"
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"offsets": [
[
214,
222
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],
"normalized": []
},
{
"id": "split_0_train_4677_entity",
"type": "progene_text",
"text": [
"c-Jun N - terminal kinase"
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"offsets": [
[
229,
254
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],
"normalized": []
},
{
"id": "split_0_train_4678_entity",
"type": "progene_text",
"text": [
"JNK"
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"offsets": [
[
257,
260
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],
"normalized": []
},
{
"id": "split_0_train_4679_entity",
"type": "progene_text",
"text": [
"nuclear factor - kappa B"
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"offsets": [
[
269,
293
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],
"normalized": []
},
{
"id": "split_0_train_4680_entity",
"type": "progene_text",
"text": [
"NFkappa B"
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"offsets": [
[
296,
305
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],
"normalized": []
},
{
"id": "split_0_train_4681_entity",
"type": "progene_text",
"text": [
"IL-1Rrp2"
],
"offsets": [
[
338,
346
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2915 | split_0_train_2915 | [
{
"id": "split_0_train_2915_passage",
"type": "progene_text",
"text": [
"The aim of this study was to test the hypothesis that IL-1F8 contributes to brain inflammation and injury , by studying its expression and actions in the different cell types of the mouse brain in culture ."
],
"offsets": [
[
0,
206
]
]
}
]
| [
{
"id": "split_0_train_4682_entity",
"type": "progene_text",
"text": [
"IL-1F8"
],
"offsets": [
[
54,
60
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2916 | split_0_train_2916 | [
{
"id": "split_0_train_2916_passage",
"type": "progene_text",
"text": [
"Messenger RNA for IL-1F8 was detected in neurons and glia ( microglial cells , oligodendrocytes progenitor cells and to a lesser extent astrocytes ) by RT - PCR ."
],
"offsets": [
[
0,
162
]
]
}
]
| [
{
"id": "split_0_train_4683_entity",
"type": "progene_text",
"text": [
"IL-1F8"
],
"offsets": [
[
18,
24
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2917 | split_0_train_2917 | [
{
"id": "split_0_train_2917_passage",
"type": "progene_text",
"text": [
"Bacterial lipopolysaccharide ( LPS ) had no effect on IL-1F8 mRNA levels in mixed glial cultures ."
],
"offsets": [
[
0,
98
]
]
}
]
| [
{
"id": "split_0_train_4684_entity",
"type": "progene_text",
"text": [
"IL-1F8"
],
"offsets": [
[
54,
60
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2918 | split_0_train_2918 | [
{
"id": "split_0_train_2918_passage",
"type": "progene_text",
"text": [
"Recombinant mouse IL-1beta induced strong activation of ERK1 / 2 , p38 , JNK and NFkappa B , and significant release of IL-6 and PGE2 , which was blocked by IL-1ra ."
],
"offsets": [
[
0,
165
]
]
}
]
| [
{
"id": "split_0_train_4685_entity",
"type": "progene_text",
"text": [
"IL-1beta"
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"offsets": [
[
18,
26
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{
"id": "split_0_train_4686_entity",
"type": "progene_text",
"text": [
"ERK1 / 2"
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[
56,
64
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},
{
"id": "split_0_train_4687_entity",
"type": "progene_text",
"text": [
"p38"
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67,
70
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},
{
"id": "split_0_train_4688_entity",
"type": "progene_text",
"text": [
"JNK"
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73,
76
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"normalized": []
},
{
"id": "split_0_train_4689_entity",
"type": "progene_text",
"text": [
"NFkappa B"
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81,
90
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},
{
"id": "split_0_train_4690_entity",
"type": "progene_text",
"text": [
"IL-6"
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[
120,
124
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},
{
"id": "split_0_train_4691_entity",
"type": "progene_text",
"text": [
"IL-1ra"
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"offsets": [
[
157,
163
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2919 | split_0_train_2919 | [
{
"id": "split_0_train_2919_passage",
"type": "progene_text",
"text": [
"In contrast , recombinant mouse IL-1F8 did not influence any of these parameters ."
],
"offsets": [
[
0,
82
]
]
}
]
| [
{
"id": "split_0_train_4692_entity",
"type": "progene_text",
"text": [
"IL-1F8"
],
"offsets": [
[
32,
38
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2920 | split_0_train_2920 | [
{
"id": "split_0_train_2920_passage",
"type": "progene_text",
"text": [
"These results demonstrate that CNS cells may be a source of IL-1F8 , but the failure of LPS to modulate IL-1F8 mRNA expression , and of recombinant IL-1F8 to induce any of the classical IL-1 responses , suggest that this cytokine has restricted activities in the brain , or that it may act via alternative pathway(s) ."
],
"offsets": [
[
0,
318
]
]
}
]
| [
{
"id": "split_0_train_4693_entity",
"type": "progene_text",
"text": [
"IL-1F8"
],
"offsets": [
[
60,
66
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],
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},
{
"id": "split_0_train_4694_entity",
"type": "progene_text",
"text": [
"IL-1F8"
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"offsets": [
[
104,
110
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],
"normalized": []
},
{
"id": "split_0_train_4695_entity",
"type": "progene_text",
"text": [
"IL-1F8"
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"offsets": [
[
148,
154
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],
"normalized": []
},
{
"id": "split_0_train_4696_entity",
"type": "progene_text",
"text": [
"IL-1"
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[
186,
190
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],
"normalized": []
},
{
"id": "split_0_train_4697_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
221,
229
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2921 | split_0_train_2921 | [
{
"id": "split_0_train_2921_passage",
"type": "progene_text",
"text": [
"Residues Met76 and Gln79 in HLA-G alpha1 domain involve in KIR2DL4 recognition ."
],
"offsets": [
[
0,
80
]
]
}
]
| [
{
"id": "split_0_train_4698_entity",
"type": "progene_text",
"text": [
"HLA-G"
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[
28,
33
]
],
"normalized": []
},
{
"id": "split_0_train_4699_entity",
"type": "progene_text",
"text": [
"KIR2DL4"
],
"offsets": [
[
59,
66
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2922 | split_0_train_2922 | [
{
"id": "split_0_train_2922_passage",
"type": "progene_text",
"text": [
"Human leukocyte antigen - G ( HLA-G ) has long been speculated as a beneficial factor for a successful pregnancy for its restricted expression on fetal - maternal extravillous cytotrophoblasts and its capability of modulating uterine natural killer cell ( uNK ) function such as cytotoxicity and cytokine production through NK cell receptors ."
],
"offsets": [
[
0,
343
]
]
}
]
| [
{
"id": "split_0_train_4700_entity",
"type": "progene_text",
"text": [
"Human leukocyte antigen - G"
],
"offsets": [
[
0,
27
]
],
"normalized": []
},
{
"id": "split_0_train_4701_entity",
"type": "progene_text",
"text": [
"HLA-G"
],
"offsets": [
[
30,
35
]
],
"normalized": []
},
{
"id": "split_0_train_4702_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
296,
304
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2923 | split_0_train_2923 | [
{
"id": "split_0_train_2923_passage",
"type": "progene_text",
"text": [
"HLA class I alpha1 domain is an important killer cell Ig - like receptor ( KIR ) recognition site and the Met76 and Gln79 are unique to HLA-G in this region ."
],
"offsets": [
[
0,
158
]
]
}
]
| [
{
"id": "split_0_train_4703_entity",
"type": "progene_text",
"text": [
"HLA class I"
],
"offsets": [
[
0,
11
]
],
"normalized": []
},
{
"id": "split_0_train_4704_entity",
"type": "progene_text",
"text": [
"killer cell Ig - like receptor"
],
"offsets": [
[
42,
72
]
],
"normalized": []
},
{
"id": "split_0_train_4705_entity",
"type": "progene_text",
"text": [
"KIR"
],
"offsets": [
[
75,
78
]
],
"normalized": []
},
{
"id": "split_0_train_4706_entity",
"type": "progene_text",
"text": [
"HLA-G"
],
"offsets": [
[
136,
141
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2924 | split_0_train_2924 | [
{
"id": "split_0_train_2924_passage",
"type": "progene_text",
"text": [
"NK cell receptor KIR2DL4 is a specific receptor for HLA-G , yet the recognition site on HLA-G remains unknown ."
],
"offsets": [
[
0,
111
]
]
}
]
| [
{
"id": "split_0_train_4707_entity",
"type": "progene_text",
"text": [
"KIR2DL4"
],
"offsets": [
[
17,
24
]
],
"normalized": []
},
{
"id": "split_0_train_4708_entity",
"type": "progene_text",
"text": [
"HLA-G"
],
"offsets": [
[
52,
57
]
],
"normalized": []
},
{
"id": "split_0_train_4709_entity",
"type": "progene_text",
"text": [
"HLA-G"
],
"offsets": [
[
88,
93
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2925 | split_0_train_2925 | [
{
"id": "split_0_train_2925_passage",
"type": "progene_text",
"text": [
"In this study , retroviral transduction was applied to express the wild type HLA-G ( HLA-wtG ) , mutant HLA-G ( HLA-mG ) on the chronic myelogenous leukemia cell line K562 cells and KIR2DL4 molecule on NK-92 cells , respectively ."
],
"offsets": [
[
0,
230
]
]
}
]
| [
{
"id": "split_0_train_4710_entity",
"type": "progene_text",
"text": [
"HLA-G"
],
"offsets": [
[
77,
82
]
],
"normalized": []
},
{
"id": "split_0_train_4711_entity",
"type": "progene_text",
"text": [
"HLA-wtG"
],
"offsets": [
[
85,
92
]
],
"normalized": []
},
{
"id": "split_0_train_4712_entity",
"type": "progene_text",
"text": [
"HLA-G"
],
"offsets": [
[
104,
109
]
],
"normalized": []
},
{
"id": "split_0_train_4713_entity",
"type": "progene_text",
"text": [
"HLA-mG"
],
"offsets": [
[
112,
118
]
],
"normalized": []
},
{
"id": "split_0_train_4714_entity",
"type": "progene_text",
"text": [
"KIR2DL4"
],
"offsets": [
[
182,
189
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2926 | split_0_train_2926 | [
{
"id": "split_0_train_2926_passage",
"type": "progene_text",
"text": [
"KIR2DL4 - IgG Fc fusion protein was generated to determine the binding specificity between KIR2DL4 and HLA-G ."
],
"offsets": [
[
0,
110
]
]
}
]
| [
{
"id": "split_0_train_4715_entity",
"type": "progene_text",
"text": [
"KIR2DL4"
],
"offsets": [
[
0,
7
]
],
"normalized": []
},
{
"id": "split_0_train_4716_entity",
"type": "progene_text",
"text": [
"IgG"
],
"offsets": [
[
10,
13
]
],
"normalized": []
},
{
"id": "split_0_train_4717_entity",
"type": "progene_text",
"text": [
"KIR2DL4"
],
"offsets": [
[
91,
98
]
],
"normalized": []
},
{
"id": "split_0_train_4718_entity",
"type": "progene_text",
"text": [
"HLA-G"
],
"offsets": [
[
103,
108
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2927 | split_0_train_2927 | [
{
"id": "split_0_train_2927_passage",
"type": "progene_text",
"text": [
"Our results showed that residue Met76 , Gln79 mutated to Ala76 , 79 in the alpha1 domain of HLA-G protein could affect the binding affinity between KIR2DL4 and HLA-G , meanwhile , the KIR2DL4 transfected NK-92 cells ( NK-92 - 2DL4 ) showed a considerably different cytolysis ability against the HLA-wtG and HLA-mG transfected K562 targets ."
],
"offsets": [
[
0,
340
]
]
}
]
| [
{
"id": "split_0_train_4719_entity",
"type": "progene_text",
"text": [
"HLA-G"
],
"offsets": [
[
92,
97
]
],
"normalized": []
},
{
"id": "split_0_train_4720_entity",
"type": "progene_text",
"text": [
"KIR2DL4"
],
"offsets": [
[
148,
155
]
],
"normalized": []
},
{
"id": "split_0_train_4721_entity",
"type": "progene_text",
"text": [
"HLA-G"
],
"offsets": [
[
160,
165
]
],
"normalized": []
},
{
"id": "split_0_train_4722_entity",
"type": "progene_text",
"text": [
"KIR2DL4"
],
"offsets": [
[
184,
191
]
],
"normalized": []
},
{
"id": "split_0_train_4723_entity",
"type": "progene_text",
"text": [
"2DL4"
],
"offsets": [
[
226,
230
]
],
"normalized": []
},
{
"id": "split_0_train_4724_entity",
"type": "progene_text",
"text": [
"HLA-wtG"
],
"offsets": [
[
295,
302
]
],
"normalized": []
},
{
"id": "split_0_train_4725_entity",
"type": "progene_text",
"text": [
"HLA-mG"
],
"offsets": [
[
307,
313
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2928 | split_0_train_2928 | [
{
"id": "split_0_train_2928_passage",
"type": "progene_text",
"text": [
"Taken together , our data indicated that residue Met76 and Gln79 in HLA-G alpha1 domain plays a critical role in the recognition of KIR2DL4 , which could be an explanation for the isoforms of HLA-G , all containing the a1 domain , with the potential to regulate NK functions ."
],
"offsets": [
[
0,
276
]
]
}
]
| [
{
"id": "split_0_train_4726_entity",
"type": "progene_text",
"text": [
"HLA-G"
],
"offsets": [
[
68,
73
]
],
"normalized": []
},
{
"id": "split_0_train_4727_entity",
"type": "progene_text",
"text": [
"KIR2DL4"
],
"offsets": [
[
132,
139
]
],
"normalized": []
},
{
"id": "split_0_train_4728_entity",
"type": "progene_text",
"text": [
"HLA-G"
],
"offsets": [
[
192,
197
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2929 | split_0_train_2929 | [
{
"id": "split_0_train_2929_passage",
"type": "progene_text",
"text": [
"B cell memory to 3 Plasmodium falciparum blood - stage antigens in a malaria - endemic area ."
],
"offsets": [
[
0,
93
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2930 | split_0_train_2930 | [
{
"id": "split_0_train_2930_passage",
"type": "progene_text",
"text": [
"To gain insight into why antibody responses to malarial antigens tend to be short lived , we studied antigen - specific memory B cells from donors in an area where malaria is endemic ."
],
"offsets": [
[
0,
184
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2931 | split_0_train_2931 | [
{
"id": "split_0_train_2931_passage",
"type": "progene_text",
"text": [
"We compared antibody and memory B cell responses to tetanus toxoid with those to 3 Plasmodium falciparum candidate vaccine antigens : the C - terminal portion of merozoite surface protein 1 ( MSP1 ( 19 ) ) , apical membrane antigen 1 ( AMA1 ) , and the cysteine - rich interdomain region 1 alpha ( CIDR1 alpha ) of a protein from the P. falciparum erythrocyte membrane protein 1 ( PfEMP1 ) family ."
],
"offsets": [
[
0,
398
]
]
}
]
| [
{
"id": "split_0_train_4729_entity",
"type": "progene_text",
"text": [
"merozoite surface protein 1"
],
"offsets": [
[
162,
189
]
],
"normalized": []
},
{
"id": "split_0_train_4730_entity",
"type": "progene_text",
"text": [
"MSP1"
],
"offsets": [
[
192,
196
]
],
"normalized": []
},
{
"id": "split_0_train_4731_entity",
"type": "progene_text",
"text": [
"apical membrane antigen 1"
],
"offsets": [
[
208,
233
]
],
"normalized": []
},
{
"id": "split_0_train_4732_entity",
"type": "progene_text",
"text": [
"AMA1"
],
"offsets": [
[
236,
240
]
],
"normalized": []
},
{
"id": "split_0_train_4733_entity",
"type": "progene_text",
"text": [
"P. falciparum erythrocyte membrane protein 1 ( PfEMP1 ) family"
],
"offsets": [
[
334,
396
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2932 | split_0_train_2932 | [
{
"id": "split_0_train_2932_passage",
"type": "progene_text",
"text": [
"These data are the first to be generated on memory B cells in children who are in the process of acquiring antimalarial immunity , and they reveal defects in B cell memory to P. falciparum antigens ."
],
"offsets": [
[
0,
199
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2933 | split_0_train_2933 | [
{
"id": "split_0_train_2933_passage",
"type": "progene_text",
"text": [
"Compared with the results for tetanus toxoid , more donors who were positive for antibody to AMA1 and CIDR1 alpha were negative for memory B cells ."
],
"offsets": [
[
0,
148
]
]
}
]
| [
{
"id": "split_0_train_4734_entity",
"type": "progene_text",
"text": [
"AMA1"
],
"offsets": [
[
93,
97
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2934 | split_0_train_2934 | [
{
"id": "split_0_train_2934_passage",
"type": "progene_text",
"text": [
"These data imply that some exposures to malaria do not result in the establishment of stable populations of circulating antigen - specific memory B cells , suggesting possible mechanisms for the short - lived nature of many anti - malarial antibody responses ."
],
"offsets": [
[
0,
260
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2935 | split_0_train_2935 | [
{
"id": "split_0_train_2935_passage",
"type": "progene_text",
"text": [
"Immune - regulation of the apolipoprotein A-I / C-III/A-IV gene cluster in experimental inflammation ."
],
"offsets": [
[
0,
102
]
]
}
]
| [
{
"id": "split_0_train_4735_entity",
"type": "progene_text",
"text": [
"apolipoprotein A-I / C-III/A-IV"
],
"offsets": [
[
27,
58
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2936 | split_0_train_2936 | [
{
"id": "split_0_train_2936_passage",
"type": "progene_text",
"text": [
"Apolipoprotein A-IV is a member of the apo A-I / C-III/A - IV gene cluster ."
],
"offsets": [
[
0,
76
]
]
}
]
| [
{
"id": "split_0_train_4736_entity",
"type": "progene_text",
"text": [
"Apolipoprotein A-IV"
],
"offsets": [
[
0,
19
]
],
"normalized": []
},
{
"id": "split_0_train_4737_entity",
"type": "progene_text",
"text": [
"apo A-I / C-III/A - IV"
],
"offsets": [
[
39,
61
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2937 | split_0_train_2937 | [
{
"id": "split_0_train_2937_passage",
"type": "progene_text",
"text": [
"In order to investigate its hypothetical coordinated regulation , an acute phase was induced in pigs by turpentine oil injection ."
],
"offsets": [
[
0,
130
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2938 | split_0_train_2938 | [
{
"id": "split_0_train_2938_passage",
"type": "progene_text",
"text": [
"The hepatic expression of the gene cluster as well as the plasma levels of apolipoproteins were monitored at different time periods ."
],
"offsets": [
[
0,
133
]
]
}
]
| [
{
"id": "split_0_train_4738_entity",
"type": "progene_text",
"text": [
"apolipoproteins"
],
"offsets": [
[
75,
90
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2939 | split_0_train_2939 | [
{
"id": "split_0_train_2939_passage",
"type": "progene_text",
"text": [
"Furthermore , the involvement of the inflammatory mediators ' interleukins 1 and 6 and tumor necrosis factor in the regulation of this gene cluster was tested in cultured pig hepatocytes , incubated with those mediators and apo A-I / C-III / A-IV gene cluster expression at the mRNA level was measured ."
],
"offsets": [
[
0,
303
]
]
}
]
| [
{
"id": "split_0_train_4739_entity",
"type": "progene_text",
"text": [
"interleukins 1 and 6"
],
"offsets": [
[
62,
82
]
],
"normalized": []
},
{
"id": "split_0_train_4740_entity",
"type": "progene_text",
"text": [
"tumor necrosis factor"
],
"offsets": [
[
87,
108
]
],
"normalized": []
},
{
"id": "split_0_train_4741_entity",
"type": "progene_text",
"text": [
"apo A-I / C-III / A-IV"
],
"offsets": [
[
224,
246
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2940 | split_0_train_2940 | [
{
"id": "split_0_train_2940_passage",
"type": "progene_text",
"text": [
"In response to turpentine oil - induced inflammation , a decreased hepatic apo A - IV mRNA expression was observed ( independent of apo A-I and apo C-III mRNA ) not correlating with the plasma protein levels ."
],
"offsets": [
[
0,
209
]
]
}
]
| [
{
"id": "split_0_train_4742_entity",
"type": "progene_text",
"text": [
"apo A - IV"
],
"offsets": [
[
75,
85
]
],
"normalized": []
},
{
"id": "split_0_train_4743_entity",
"type": "progene_text",
"text": [
"apo A-I"
],
"offsets": [
[
132,
139
]
],
"normalized": []
},
{
"id": "split_0_train_4744_entity",
"type": "progene_text",
"text": [
"apo C-III"
],
"offsets": [
[
144,
153
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2941 | split_0_train_2941 | [
{
"id": "split_0_train_2941_passage",
"type": "progene_text",
"text": [
"The distribution of plasma apo A - IV experienced a shift from HDL to larger particles ."
],
"offsets": [
[
0,
88
]
]
}
]
| [
{
"id": "split_0_train_4745_entity",
"type": "progene_text",
"text": [
"apo A - IV"
],
"offsets": [
[
27,
37
]
],
"normalized": []
},
{
"id": "split_0_train_4746_entity",
"type": "progene_text",
"text": [
"HDL"
],
"offsets": [
[
63,
66
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2942 | split_0_train_2942 | [
{
"id": "split_0_train_2942_passage",
"type": "progene_text",
"text": [
"In contrast , the changes in apo A-I and apo C-III mRNA were reflected in their corresponding plasma levels ."
],
"offsets": [
[
0,
109
]
]
}
]
| [
{
"id": "split_0_train_4747_entity",
"type": "progene_text",
"text": [
"apo A-I"
],
"offsets": [
[
29,
36
]
],
"normalized": []
},
{
"id": "split_0_train_4748_entity",
"type": "progene_text",
"text": [
"apo C-III"
],
"offsets": [
[
41,
50
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2943 | split_0_train_2943 | [
{
"id": "split_0_train_2943_passage",
"type": "progene_text",
"text": [
"Addition of cytokines to cultured pig hepatocytes also decreased apo A - IV and apo A-I mRNA levels ."
],
"offsets": [
[
0,
101
]
]
}
]
| [
{
"id": "split_0_train_4749_entity",
"type": "progene_text",
"text": [
"cytokines"
],
"offsets": [
[
12,
21
]
],
"normalized": []
},
{
"id": "split_0_train_4750_entity",
"type": "progene_text",
"text": [
"apo A - IV"
],
"offsets": [
[
65,
75
]
],
"normalized": []
},
{
"id": "split_0_train_4751_entity",
"type": "progene_text",
"text": [
"apo A-I"
],
"offsets": [
[
80,
87
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2944 | split_0_train_2944 | [
{
"id": "split_0_train_2944_passage",
"type": "progene_text",
"text": [
"All these results show that the down - regulation of apolipoprotein A-I and A-IV messages in the liver may be mediated by interleukin 6 and TNF-alpha ."
],
"offsets": [
[
0,
151
]
]
}
]
| [
{
"id": "split_0_train_4752_entity",
"type": "progene_text",
"text": [
"apolipoprotein A-I and A-IV"
],
"offsets": [
[
53,
80
]
],
"normalized": []
},
{
"id": "split_0_train_4753_entity",
"type": "progene_text",
"text": [
"interleukin 6"
],
"offsets": [
[
122,
135
]
],
"normalized": []
},
{
"id": "split_0_train_4754_entity",
"type": "progene_text",
"text": [
"TNF-alpha"
],
"offsets": [
[
140,
149
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2945 | split_0_train_2945 | [
{
"id": "split_0_train_2945_passage",
"type": "progene_text",
"text": [
"The well - known HDL decrease found in many different acute - phase responses also appears in the pig due to the decreased expression of apolipoprotein A-I and the enlargement of the apolipoprotein A - IV - containing HDL ."
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[
0,
223
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]
| [
{
"id": "split_0_train_4755_entity",
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17,
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{
"id": "split_0_train_4756_entity",
"type": "progene_text",
"text": [
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137,
155
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},
{
"id": "split_0_train_4757_entity",
"type": "progene_text",
"text": [
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183,
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{
"id": "split_0_train_4758_entity",
"type": "progene_text",
"text": [
"HDL"
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[
218,
221
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}
]
| []
| []
| []
|
split_0_train_2946 | split_0_train_2946 | [
{
"id": "split_0_train_2946_passage",
"type": "progene_text",
"text": [
"Transcript profiling of immediate early genes reveals a unique role for activating transcription factor 3 in mediating activation of the glycoprotein hormone alpha - subunit promoter by gonadotropin - releasing hormone ."
],
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[
0,
220
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]
}
]
| [
{
"id": "split_0_train_4759_entity",
"type": "progene_text",
"text": [
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[
72,
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},
{
"id": "split_0_train_4760_entity",
"type": "progene_text",
"text": [
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137,
163
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},
{
"id": "split_0_train_4761_entity",
"type": "progene_text",
"text": [
"gonadotropin - releasing hormone"
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"offsets": [
[
186,
218
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],
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}
]
| []
| []
| []
|
split_0_train_2947 | split_0_train_2947 | [
{
"id": "split_0_train_2947_passage",
"type": "progene_text",
"text": [
"Recent studies profiling immediate early gene responses to GnRH in the LbetaT2 gonadotrope cell model revealed increased expression of numerous genes including activating transcription factor ( ATF ) 3 ."
],
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[
0,
203
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]
}
]
| [
{
"id": "split_0_train_4762_entity",
"type": "progene_text",
"text": [
"GnRH"
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[
59,
63
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},
{
"id": "split_0_train_4763_entity",
"type": "progene_text",
"text": [
"activating transcription factor ( ATF ) 3"
],
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[
160,
201
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2948 | split_0_train_2948 | [
{
"id": "split_0_train_2948_passage",
"type": "progene_text",
"text": [
"The present studies demonstrate similar results with GnRH administration in vivo in ovariectomized mice ."
],
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[
0,
105
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]
}
]
| [
{
"id": "split_0_train_4764_entity",
"type": "progene_text",
"text": [
"GnRH"
],
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[
53,
57
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2949 | split_0_train_2949 | [
{
"id": "split_0_train_2949_passage",
"type": "progene_text",
"text": [
"In this model , ATF3 mRNA was markedly up - regulated at 20 , 40 , and 60 min after in vivo administration of a GnRH analog ."
],
"offsets": [
[
0,
125
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]
}
]
| [
{
"id": "split_0_train_4765_entity",
"type": "progene_text",
"text": [
"ATF3"
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[
16,
20
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},
{
"id": "split_0_train_4766_entity",
"type": "progene_text",
"text": [
"GnRH"
],
"offsets": [
[
112,
116
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2950 | split_0_train_2950 | [
{
"id": "split_0_train_2950_passage",
"type": "progene_text",
"text": [
"In alphaT3-1 gonadotrope cells , ATF3 mRNA and protein were induced by GnRH in a manner consistent with in vivo observations ."
],
"offsets": [
[
0,
126
]
]
}
]
| [
{
"id": "split_0_train_4767_entity",
"type": "progene_text",
"text": [
"ATF3"
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[
33,
37
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],
"normalized": []
},
{
"id": "split_0_train_4768_entity",
"type": "progene_text",
"text": [
"GnRH"
],
"offsets": [
[
71,
75
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2951 | split_0_train_2951 | [
{
"id": "split_0_train_2951_passage",
"type": "progene_text",
"text": [
"Pharmacological studies implicated a combined role for the activities of protein kinase C isozymes , ERK and c-Jun N - terminal kinase , in modulating ATF3 expression ."
],
"offsets": [
[
0,
168
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]
}
]
| [
{
"id": "split_0_train_4769_entity",
"type": "progene_text",
"text": [
"protein kinase C"
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[
73,
89
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},
{
"id": "split_0_train_4770_entity",
"type": "progene_text",
"text": [
"ERK"
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[
101,
104
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],
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},
{
"id": "split_0_train_4771_entity",
"type": "progene_text",
"text": [
"c-Jun N - terminal kinase"
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[
109,
134
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],
"normalized": []
},
{
"id": "split_0_train_4772_entity",
"type": "progene_text",
"text": [
"ATF3"
],
"offsets": [
[
151,
155
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2952 | split_0_train_2952 | [
{
"id": "split_0_train_2952_passage",
"type": "progene_text",
"text": [
"The role of ATF3 was further investigated in the activation of the human glycoprotein hormone alpha - subunit gene promoter ."
],
"offsets": [
[
0,
125
]
]
}
]
| [
{
"id": "split_0_train_4773_entity",
"type": "progene_text",
"text": [
"ATF3"
],
"offsets": [
[
12,
16
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],
"normalized": []
},
{
"id": "split_0_train_4774_entity",
"type": "progene_text",
"text": [
"glycoprotein hormone alpha"
],
"offsets": [
[
73,
99
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2953 | split_0_train_2953 | [
{
"id": "split_0_train_2953_passage",
"type": "progene_text",
"text": [
"GnRH induced the alpha - subunit promoter - luciferase reporter approximately 16 - fold , and this induction was completely abolished with mutations in the dual cAMP response elements ( CREs ) or the combined inhibition of GnRH - induced ERK and c-Jun N - terminal kinase ."
],
"offsets": [
[
0,
273
]
]
}
]
| [
{
"id": "split_0_train_4775_entity",
"type": "progene_text",
"text": [
"GnRH"
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[
0,
4
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},
{
"id": "split_0_train_4776_entity",
"type": "progene_text",
"text": [
"luciferase"
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[
44,
54
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],
"normalized": []
},
{
"id": "split_0_train_4777_entity",
"type": "progene_text",
"text": [
"GnRH"
],
"offsets": [
[
223,
227
]
],
"normalized": []
},
{
"id": "split_0_train_4778_entity",
"type": "progene_text",
"text": [
"ERK"
],
"offsets": [
[
238,
241
]
],
"normalized": []
},
{
"id": "split_0_train_4779_entity",
"type": "progene_text",
"text": [
"c-Jun N - terminal kinase"
],
"offsets": [
[
246,
271
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2954 | split_0_train_2954 | [
{
"id": "split_0_train_2954_passage",
"type": "progene_text",
"text": [
"GnRH induced recruitment of ATF3 , c-Jun , and c-Fos to the dual CREs ."
],
"offsets": [
[
0,
71
]
]
}
]
| [
{
"id": "split_0_train_4780_entity",
"type": "progene_text",
"text": [
"GnRH"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_4781_entity",
"type": "progene_text",
"text": [
"ATF3"
],
"offsets": [
[
28,
32
]
],
"normalized": []
},
{
"id": "split_0_train_4782_entity",
"type": "progene_text",
"text": [
"c-Jun"
],
"offsets": [
[
35,
40
]
],
"normalized": []
},
{
"id": "split_0_train_4783_entity",
"type": "progene_text",
"text": [
"c-Fos"
],
"offsets": [
[
47,
52
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2955 | split_0_train_2955 | [
{
"id": "split_0_train_2955_passage",
"type": "progene_text",
"text": [
"Overexpression and specific knockdown of ATF3 by small inhibitory RNA implicate a functional role for ATF3 in mediating activation of the alpha-subunit gene promoter ."
],
"offsets": [
[
0,
167
]
]
}
]
| [
{
"id": "split_0_train_4784_entity",
"type": "progene_text",
"text": [
"ATF3"
],
"offsets": [
[
41,
45
]
],
"normalized": []
},
{
"id": "split_0_train_4785_entity",
"type": "progene_text",
"text": [
"ATF3"
],
"offsets": [
[
102,
106
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2956 | split_0_train_2956 | [
{
"id": "split_0_train_2956_passage",
"type": "progene_text",
"text": [
"These studies provide clear evidence that ATF3 is a key immediate early gene induced by GnRH administration in vivo and in the alphaT3-1 gonadotrope cell model ."
],
"offsets": [
[
0,
161
]
]
}
]
| [
{
"id": "split_0_train_4786_entity",
"type": "progene_text",
"text": [
"ATF3"
],
"offsets": [
[
42,
46
]
],
"normalized": []
},
{
"id": "split_0_train_4787_entity",
"type": "progene_text",
"text": [
"GnRH"
],
"offsets": [
[
88,
92
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2957 | split_0_train_2957 | [
{
"id": "split_0_train_2957_passage",
"type": "progene_text",
"text": [
"These studies support the conclusion that the dual CREs of the human alpha-subunit promoter are the target of GnRH - induced MAPK regulation through ATF3 ."
],
"offsets": [
[
0,
155
]
]
}
]
| [
{
"id": "split_0_train_4788_entity",
"type": "progene_text",
"text": [
"GnRH"
],
"offsets": [
[
110,
114
]
],
"normalized": []
},
{
"id": "split_0_train_4789_entity",
"type": "progene_text",
"text": [
"MAPK"
],
"offsets": [
[
125,
129
]
],
"normalized": []
},
{
"id": "split_0_train_4790_entity",
"type": "progene_text",
"text": [
"ATF3"
],
"offsets": [
[
149,
153
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2958 | split_0_train_2958 | [
{
"id": "split_0_train_2958_passage",
"type": "progene_text",
"text": [
"Expression of RPIP9 ( Rap2 interacting protein 9 ) is activated in breast carcinoma and correlates with a poor prognosis ."
],
"offsets": [
[
0,
122
]
]
}
]
| [
{
"id": "split_0_train_4791_entity",
"type": "progene_text",
"text": [
"RPIP9"
],
"offsets": [
[
14,
19
]
],
"normalized": []
},
{
"id": "split_0_train_4792_entity",
"type": "progene_text",
"text": [
"Rap2 interacting protein 9"
],
"offsets": [
[
22,
48
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2959 | split_0_train_2959 | [
{
"id": "split_0_train_2959_passage",
"type": "progene_text",
"text": [
"MDR1 is upregulated in many tumors ."
],
"offsets": [
[
0,
36
]
]
}
]
| [
{
"id": "split_0_train_4793_entity",
"type": "progene_text",
"text": [
"MDR1"
],
"offsets": [
[
0,
4
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2960 | split_0_train_2960 | [
{
"id": "split_0_train_2960_passage",
"type": "progene_text",
"text": [
"We have previously detected activation of the MDR1 upstream promoter in metastatic breast cancer cells ."
],
"offsets": [
[
0,
104
]
]
}
]
| [
{
"id": "split_0_train_4794_entity",
"type": "progene_text",
"text": [
"MDR1"
],
"offsets": [
[
46,
50
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2961 | split_0_train_2961 | [
{
"id": "split_0_train_2961_passage",
"type": "progene_text",
"text": [
"MDR1 overlaps with an uncharacterized gene transcribed from the opposite strand , coding for Rap2 interacting protein 9 ( RPIP9 ) ."
],
"offsets": [
[
0,
131
]
]
}
]
| [
{
"id": "split_0_train_4795_entity",
"type": "progene_text",
"text": [
"MDR1"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_4796_entity",
"type": "progene_text",
"text": [
"Rap2 interacting protein 9"
],
"offsets": [
[
93,
119
]
],
"normalized": []
},
{
"id": "split_0_train_4797_entity",
"type": "progene_text",
"text": [
"RPIP9"
],
"offsets": [
[
122,
127
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2962 | split_0_train_2962 | [
{
"id": "split_0_train_2962_passage",
"type": "progene_text",
"text": [
"Rap2 belongs to the Ras superfamily of GTPases , whose role in breast cancer remains unknown ."
],
"offsets": [
[
0,
94
]
]
}
]
| [
{
"id": "split_0_train_4798_entity",
"type": "progene_text",
"text": [
"Rap2"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_4799_entity",
"type": "progene_text",
"text": [
"Ras superfamily of GTPases"
],
"offsets": [
[
20,
46
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2963 | split_0_train_2963 | [
{
"id": "split_0_train_2963_passage",
"type": "progene_text",
"text": [
"We developed sensitive methods for detecting and quantifying RPIP9 mRNA and used it to identify these transcripts in normal human tissues , 60 biopsies of primary breast carcinoma , in isolated epithelial cells both from the primary tumor and from associated lymph nodes , and from bone marrow biopsies of 74 breast cancer patients ."
],
"offsets": [
[
0,
333
]
]
}
]
| [
{
"id": "split_0_train_4800_entity",
"type": "progene_text",
"text": [
"RPIP9"
],
"offsets": [
[
61,
66
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2964 | split_0_train_2964 | [
{
"id": "split_0_train_2964_passage",
"type": "progene_text",
"text": [
"RPIP9 is expressed at high levels in normal testis , brain and adrenal gland , and at very low levels in normal breast ."
],
"offsets": [
[
0,
120
]
]
}
]
| [
{
"id": "split_0_train_4801_entity",
"type": "progene_text",
"text": [
"RPIP9"
],
"offsets": [
[
0,
5
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2965 | split_0_train_2965 | [
{
"id": "split_0_train_2965_passage",
"type": "progene_text",
"text": [
"Tumorigenic breast carcinoma cell lines expressed RPIP9 , whereas MCF-10A and HBL - 100 that do not form tumors in nude mice had undetectable levels of RPIP9 mRNA ."
],
"offsets": [
[
0,
164
]
]
}
]
| [
{
"id": "split_0_train_4802_entity",
"type": "progene_text",
"text": [
"RPIP9"
],
"offsets": [
[
50,
55
]
],
"normalized": []
},
{
"id": "split_0_train_4803_entity",
"type": "progene_text",
"text": [
"RPIP9"
],
"offsets": [
[
152,
157
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2966 | split_0_train_2966 | [
{
"id": "split_0_train_2966_passage",
"type": "progene_text",
"text": [
"RPIP9 was activated in a high proportion of breast carcinomas ( 61.6 % ; n = 60 ) and a significant correlation with metastatic lymph node invasion ( N = 0 - 3 vs. N > 3 , where N = number of lymph nodes invaded ; p = 0.031 ) was found ."
],
"offsets": [
[
0,
237
]
]
}
]
| [
{
"id": "split_0_train_4804_entity",
"type": "progene_text",
"text": [
"RPIP9"
],
"offsets": [
[
0,
5
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2967 | split_0_train_2967 | [
{
"id": "split_0_train_2967_passage",
"type": "progene_text",
"text": [
"RPIP9 mRNA could be detected in malignant epithelial cells isolated from the primary tumor and from metastasized lymph nodes as well as in the bone marrow of significantly more poor - prognosis ( N > 3 ) than better-prognosis ( N = 0 - 3 ) patients ( p = 0.001 ) ."
],
"offsets": [
[
0,
264
]
]
}
]
| [
{
"id": "split_0_train_4805_entity",
"type": "progene_text",
"text": [
"RPIP9"
],
"offsets": [
[
0,
5
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2968 | split_0_train_2968 | [
{
"id": "split_0_train_2968_passage",
"type": "progene_text",
"text": [
"Therefore , activation of RPIP9 occurs during the malignant breast epithelial transformation and increases with progression toward an invasive phenotype ."
],
"offsets": [
[
0,
154
]
]
}
]
| [
{
"id": "split_0_train_4806_entity",
"type": "progene_text",
"text": [
"RPIP9"
],
"offsets": [
[
26,
31
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2969 | split_0_train_2969 | [
{
"id": "split_0_train_2969_passage",
"type": "progene_text",
"text": [
"The structure of Sif2p , a WD repeat protein functioning in the SET3 corepressor complex ."
],
"offsets": [
[
0,
90
]
]
}
]
| [
{
"id": "split_0_train_4807_entity",
"type": "progene_text",
"text": [
"Sif2p"
],
"offsets": [
[
17,
22
]
],
"normalized": []
},
{
"id": "split_0_train_4808_entity",
"type": "progene_text",
"text": [
"SET3"
],
"offsets": [
[
64,
68
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2970 | split_0_train_2970 | [
{
"id": "split_0_train_2970_passage",
"type": "progene_text",
"text": [
"In Saccharomyces cerevisiae , the SIF2 gene product is an integral component of the Set3 complex ( SET3C ) , an assembly of proteins with some homology to the human SMRT and N - CoR corepressor complexes ."
],
"offsets": [
[
0,
205
]
]
}
]
| [
{
"id": "split_0_train_4809_entity",
"type": "progene_text",
"text": [
"SIF2"
],
"offsets": [
[
34,
38
]
],
"normalized": []
},
{
"id": "split_0_train_4810_entity",
"type": "progene_text",
"text": [
"Set3"
],
"offsets": [
[
84,
88
]
],
"normalized": []
},
{
"id": "split_0_train_4811_entity",
"type": "progene_text",
"text": [
"SET3C"
],
"offsets": [
[
99,
104
]
],
"normalized": []
},
{
"id": "split_0_train_4812_entity",
"type": "progene_text",
"text": [
"SMRT"
],
"offsets": [
[
165,
169
]
],
"normalized": []
},
{
"id": "split_0_train_4813_entity",
"type": "progene_text",
"text": [
"N - CoR"
],
"offsets": [
[
174,
181
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2971 | split_0_train_2971 | [
{
"id": "split_0_train_2971_passage",
"type": "progene_text",
"text": [
"SET3C has histone deacetylase activity that is responsible for repressing a set of meiotic genes ."
],
"offsets": [
[
0,
98
]
]
}
]
| [
{
"id": "split_0_train_4814_entity",
"type": "progene_text",
"text": [
"SET3C"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "split_0_train_4815_entity",
"type": "progene_text",
"text": [
"histone deacetylase"
],
"offsets": [
[
10,
29
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2972 | split_0_train_2972 | [
{
"id": "split_0_train_2972_passage",
"type": "progene_text",
"text": [
"We have determined the X - ray crystal structure of a 46 kDa C - terminal domain of a SET3C core protein , Sif2p to 1.55 A resolution and a crystallographic R - factor of 19.0 % ."
],
"offsets": [
[
0,
179
]
]
}
]
| [
{
"id": "split_0_train_4816_entity",
"type": "progene_text",
"text": [
"SET3C"
],
"offsets": [
[
86,
91
]
],
"normalized": []
},
{
"id": "split_0_train_4817_entity",
"type": "progene_text",
"text": [
"Sif2p"
],
"offsets": [
[
107,
112
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2973 | split_0_train_2973 | [
{
"id": "split_0_train_2973_passage",
"type": "progene_text",
"text": [
"This domain contains an unusual eight - bladed beta - propeller structure , which differs from other transcriptional corepressor structures such as yeast Tup1p and human groucho ( Gro ) / TLE1 , which have only seven ."
],
"offsets": [
[
0,
218
]
]
}
]
| [
{
"id": "split_0_train_4818_entity",
"type": "progene_text",
"text": [
"Tup1p"
],
"offsets": [
[
154,
159
]
],
"normalized": []
},
{
"id": "split_0_train_4819_entity",
"type": "progene_text",
"text": [
"groucho"
],
"offsets": [
[
170,
177
]
],
"normalized": []
},
{
"id": "split_0_train_4820_entity",
"type": "progene_text",
"text": [
"Gro"
],
"offsets": [
[
180,
183
]
],
"normalized": []
},
{
"id": "split_0_train_4821_entity",
"type": "progene_text",
"text": [
"TLE1"
],
"offsets": [
[
188,
192
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2974 | split_0_train_2974 | [
{
"id": "split_0_train_2974_passage",
"type": "progene_text",
"text": [
"We have demonstrated intact Sif2p is a tetramer and the N - terminal LisH ( Lis - homology ) - containing domain mediates tetramerization and interaction with another component of SET3C , Snt1p ."
],
"offsets": [
[
0,
195
]
]
}
]
| [
{
"id": "split_0_train_4822_entity",
"type": "progene_text",
"text": [
"Sif2p"
],
"offsets": [
[
28,
33
]
],
"normalized": []
},
{
"id": "split_0_train_4823_entity",
"type": "progene_text",
"text": [
"Lis"
],
"offsets": [
[
76,
79
]
],
"normalized": []
},
{
"id": "split_0_train_4824_entity",
"type": "progene_text",
"text": [
"SET3C"
],
"offsets": [
[
180,
185
]
],
"normalized": []
},
{
"id": "split_0_train_4825_entity",
"type": "progene_text",
"text": [
"Snt1p"
],
"offsets": [
[
188,
193
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2975 | split_0_train_2975 | [
{
"id": "split_0_train_2975_passage",
"type": "progene_text",
"text": [
"Multiple sequence alignments indicate that a surface on the \" top \" of the protein is conserved among species , suggesting that it may play a common role in binding partner proteins ."
],
"offsets": [
[
0,
183
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2976 | split_0_train_2976 | [
{
"id": "split_0_train_2976_passage",
"type": "progene_text",
"text": [
"Since Sif2p appears to be the yeast homolog of human TBL1 and TBLR1 , which function in the N - CoR / SMRT complexes , its structural and oligomeric properties are likely to be very similar ."
],
"offsets": [
[
0,
191
]
]
}
]
| [
{
"id": "split_0_train_4826_entity",
"type": "progene_text",
"text": [
"Sif2p"
],
"offsets": [
[
6,
11
]
],
"normalized": []
},
{
"id": "split_0_train_4827_entity",
"type": "progene_text",
"text": [
"TBL1"
],
"offsets": [
[
53,
57
]
],
"normalized": []
},
{
"id": "split_0_train_4828_entity",
"type": "progene_text",
"text": [
"TBLR1"
],
"offsets": [
[
62,
67
]
],
"normalized": []
},
{
"id": "split_0_train_4829_entity",
"type": "progene_text",
"text": [
"N - CoR"
],
"offsets": [
[
92,
99
]
],
"normalized": []
},
{
"id": "split_0_train_4830_entity",
"type": "progene_text",
"text": [
"SMRT"
],
"offsets": [
[
102,
106
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2977 | split_0_train_2977 | [
{
"id": "split_0_train_2977_passage",
"type": "progene_text",
"text": [
"Systemic and vascular inflammation is elevated in early IgA and type 1 diabetic nephropathies and relates to vascular disease risk factors and renal function ."
],
"offsets": [
[
0,
159
]
]
}
]
| [
{
"id": "split_0_train_4831_entity",
"type": "progene_text",
"text": [
"IgA"
],
"offsets": [
[
56,
59
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2978 | split_0_train_2978 | [
{
"id": "split_0_train_2978_passage",
"type": "progene_text",
"text": [
"BACKGROUND :"
],
"offsets": [
[
0,
12
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2979 | split_0_train_2979 | [
{
"id": "split_0_train_2979_passage",
"type": "progene_text",
"text": [
"Inflammation is implicated in cardiovascular disease ( CVD ) and mortality in end - stage renal failure ( ESRF ) ."
],
"offsets": [
[
0,
114
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2980 | split_0_train_2980 | [
{
"id": "split_0_train_2980_passage",
"type": "progene_text",
"text": [
"Its importance in early renal disease is yet to be defined ."
],
"offsets": [
[
0,
60
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2981 | split_0_train_2981 | [
{
"id": "split_0_train_2981_passage",
"type": "progene_text",
"text": [
"METHODS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2982 | split_0_train_2982 | [
{
"id": "split_0_train_2982_passage",
"type": "progene_text",
"text": [
"Serum levels of systemic and vascular inflammatory markers in early IgA nephropathy ( IgAN ) and control subjects were measured and related to renal function and vascular risk factors ."
],
"offsets": [
[
0,
185
]
]
}
]
| [
{
"id": "split_0_train_4832_entity",
"type": "progene_text",
"text": [
"IgA"
],
"offsets": [
[
68,
71
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2983 | split_0_train_2983 | [
{
"id": "split_0_train_2983_passage",
"type": "progene_text",
"text": [
"A parallel study in type 1 diabetes mellitus subjects with ( T1DM Nx ) and without nephropathy ( T1DM No Nx ) was performed ."
],
"offsets": [
[
0,
125
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2984 | split_0_train_2984 | [
{
"id": "split_0_train_2984_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2985 | split_0_train_2985 | [
{
"id": "split_0_train_2985_passage",
"type": "progene_text",
"text": [
"Fifty - one IgAN patients aged 46 +/-2 years ( mean +/-SEM ) , calculated creatinine clearance ( CrCl ) 88 + / - 5 ml / min , were compared with 51 matched control subjects ."
],
"offsets": [
[
0,
174
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2986 | split_0_train_2986 | [
{
"id": "split_0_train_2986_passage",
"type": "progene_text",
"text": [
"Forty-six T1DM Nx patients aged 40 + / - 2 years , CrCl 84 + / - 5 ml / min , and 73 T1DM No Nx patients aged 38 + / - 2 years were also compared ."
],
"offsets": [
[
0,
147
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2987 | split_0_train_2987 | [
{
"id": "split_0_train_2987_passage",
"type": "progene_text",
"text": [
"High sensitivity C - reactive protein ( hsCRP ) was elevated in IgAN , T1DM Nx and T1DM No Nx patients compared with controls [ 4.2 +/- 0.6 ( P < 0.001 ) , 4.1 +/- 0.6 ( P < 0.001 ) , 2.6 +/- 0.4 ( P < 0.05 ) vs 1.6 + / - 0.3 mg / l ] ."
],
"offsets": [
[
0,
236
]
]
}
]
| [
{
"id": "split_0_train_4833_entity",
"type": "progene_text",
"text": [
"C - reactive protein"
],
"offsets": [
[
17,
37
]
],
"normalized": []
},
{
"id": "split_0_train_4834_entity",
"type": "progene_text",
"text": [
"hsCRP"
],
"offsets": [
[
40,
45
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2988 | split_0_train_2988 | [
{
"id": "split_0_train_2988_passage",
"type": "progene_text",
"text": [
"Levels in T1DM Nx patients were higher than in T1DM No Nx patients ( P < 0.05 ) ."
],
"offsets": [
[
0,
81
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2989 | split_0_train_2989 | [
{
"id": "split_0_train_2989_passage",
"type": "progene_text",
"text": [
"Inflammation and vascular dysfunction as measured by pulse pressure ( PP ) were related ."
],
"offsets": [
[
0,
89
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2990 | split_0_train_2990 | [
{
"id": "split_0_train_2990_passage",
"type": "progene_text",
"text": [
"HsCRP correlated with PP in IgAN and T1DM Nx ( r = 0.47 , P = 0.001 ; r = 0.40 , P < 0.05 ) ."
],
"offsets": [
[
0,
93
]
]
}
]
| [
{
"id": "split_0_train_4835_entity",
"type": "progene_text",
"text": [
"HsCRP"
],
"offsets": [
[
0,
5
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2991 | split_0_train_2991 | [
{
"id": "split_0_train_2991_passage",
"type": "progene_text",
"text": [
"PP was the strongest independent predictor of hsCRP in IgAN ( T = 2.45 , P < 0.001 ) , while body mass index ( T = 7.83 , P < 0.001 ) was the strongest predictor in T1DM Nx ."
],
"offsets": [
[
0,
174
]
]
}
]
| [
{
"id": "split_0_train_4836_entity",
"type": "progene_text",
"text": [
"hsCRP"
],
"offsets": [
[
46,
51
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2992 | split_0_train_2992 | [
{
"id": "split_0_train_2992_passage",
"type": "progene_text",
"text": [
"Endothelial cell adhesion molecules were increased in T1DM Nx > IgAN > T1DM No Nx vs controls : soluble vascular adhesion molecule-1 ( sVCAM-1 ) 760 +/- 30 ( P < 0.001 ) > 663+/- 34 ( P = 0.001 ) > 601+ / - 21 ( P < 0.05 ) vs 536 + / - 15 ng / ml ; soluble intracellular adhesion molecule-1 ( sICAM-1 ) 320 + / - 8 ( P < 0.001 ) > 313+ / - 13 ( P < 0.001 ) > 307+/- 8 ( P < 0.001 ) vs 244 + / - 6 ng / ml ."
],
"offsets": [
[
0,
406
]
]
}
]
| [
{
"id": "split_0_train_4837_entity",
"type": "progene_text",
"text": [
"adhesion molecules"
],
"offsets": [
[
17,
35
]
],
"normalized": []
},
{
"id": "split_0_train_4838_entity",
"type": "progene_text",
"text": [
"vascular adhesion molecule-1"
],
"offsets": [
[
104,
132
]
],
"normalized": []
},
{
"id": "split_0_train_4839_entity",
"type": "progene_text",
"text": [
"sVCAM-1"
],
"offsets": [
[
135,
142
]
],
"normalized": []
},
{
"id": "split_0_train_4840_entity",
"type": "progene_text",
"text": [
"intracellular adhesion molecule-1"
],
"offsets": [
[
257,
290
]
],
"normalized": []
},
{
"id": "split_0_train_4841_entity",
"type": "progene_text",
"text": [
"sICAM-1"
],
"offsets": [
[
293,
300
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2993 | split_0_train_2993 | [
{
"id": "split_0_train_2993_passage",
"type": "progene_text",
"text": [
"sVCAM-1 levels were higher in T1DM Nx than in T1DM No Nx , P < 0.001 ."
],
"offsets": [
[
0,
70
]
]
}
]
| [
{
"id": "split_0_train_4842_entity",
"type": "progene_text",
"text": [
"sVCAM-1"
],
"offsets": [
[
0,
7
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2994 | split_0_train_2994 | [
{
"id": "split_0_train_2994_passage",
"type": "progene_text",
"text": [
"In IgAN and T1DM Nx , hsCRP correlated with sICAM-1 ( r = 0.33 , P = 0.017 ; r = 0.37 ; P = 0.017 ) ."
],
"offsets": [
[
0,
101
]
]
}
]
| [
{
"id": "split_0_train_4843_entity",
"type": "progene_text",
"text": [
"hsCRP"
],
"offsets": [
[
22,
27
]
],
"normalized": []
},
{
"id": "split_0_train_4844_entity",
"type": "progene_text",
"text": [
"sICAM-1"
],
"offsets": [
[
44,
51
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2995 | split_0_train_2995 | [
{
"id": "split_0_train_2995_passage",
"type": "progene_text",
"text": [
"sVCAM-1 was related to renal function in IgAN and T1DM Nx : serum cystatin C ( r = 0.63 , P < 0.001 : r = 0.425 , P = 0.002 ) , and urine protein : creatinine ratio in IgAN ( r = 0.48 ; P = 0.001 ) ."
],
"offsets": [
[
0,
199
]
]
}
]
| [
{
"id": "split_0_train_4845_entity",
"type": "progene_text",
"text": [
"sVCAM-1"
],
"offsets": [
[
0,
7
]
],
"normalized": []
},
{
"id": "split_0_train_4846_entity",
"type": "progene_text",
"text": [
"cystatin C"
],
"offsets": [
[
66,
76
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_2996 | split_0_train_2996 | [
{
"id": "split_0_train_2996_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2997 | split_0_train_2997 | [
{
"id": "split_0_train_2997_passage",
"type": "progene_text",
"text": [
"Systemic and vascular markers of inflammation are increased in early renal disease and relate to renal dysfunction and cardiovascular risk factors ."
],
"offsets": [
[
0,
148
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2998 | split_0_train_2998 | [
{
"id": "split_0_train_2998_passage",
"type": "progene_text",
"text": [
"Inflammation may be a common process in various renal diseases and may link and accelerate renal dysfunction and CVD ."
],
"offsets": [
[
0,
118
]
]
}
]
| []
| []
| []
| []
|
split_0_train_2999 | split_0_train_2999 | [
{
"id": "split_0_train_2999_passage",
"type": "progene_text",
"text": [
"Three - dimensional reconstruction of anomalous chloroplasts in transgenic ipt tobacco ."
],
"offsets": [
[
0,
88
]
]
}
]
| []
| []
| []
| []
|
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