id
stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
split_0_train_3000 | split_0_train_3000 | [
{
"id": "split_0_train_3000_passage",
"type": "progene_text",
"text": [
"Anomalies in the ultrastructure of chloroplasts , from transgenic ipt tobacco , overproducing endogenous cytokinins ( CKs ) were studied ."
],
"offsets": [
[
0,
138
]
]
}
]
| [
{
"id": "split_0_train_4847_entity",
"type": "progene_text",
"text": [
"cytokinins"
],
"offsets": [
[
105,
115
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3001 | split_0_train_3001 | [
{
"id": "split_0_train_3001_passage",
"type": "progene_text",
"text": [
"Detailed analyses of CKs and their metabolites showed that Pssu - ipt tobacco contained enhanced contents of CKs both in leaves and in isolated chloroplasts ."
],
"offsets": [
[
0,
158
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3002 | split_0_train_3002 | [
{
"id": "split_0_train_3002_passage",
"type": "progene_text",
"text": [
"The role of CKs in the formation of anomalous structures is suggested ."
],
"offsets": [
[
0,
71
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3003 | split_0_train_3003 | [
{
"id": "split_0_train_3003_passage",
"type": "progene_text",
"text": [
"Pssu - ipt chloroplasts frequently formed the distinct peripheral reticulum with a system of caverns that often involved mitochondria and/or peroxisomes ."
],
"offsets": [
[
0,
154
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3004 | split_0_train_3004 | [
{
"id": "split_0_train_3004_passage",
"type": "progene_text",
"text": [
"Large crystalloids , which were found in chloroplasts of Pssu - ipt , occupied up to 16 % of chloroplast volume ."
],
"offsets": [
[
0,
113
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3005 | split_0_train_3005 | [
{
"id": "split_0_train_3005_passage",
"type": "progene_text",
"text": [
"We suggested that the crystalloids were formed by LHC II aggregates ."
],
"offsets": [
[
0,
69
]
]
}
]
| [
{
"id": "split_0_train_4848_entity",
"type": "progene_text",
"text": [
"LHC II"
],
"offsets": [
[
50,
56
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3006 | split_0_train_3006 | [
{
"id": "split_0_train_3006_passage",
"type": "progene_text",
"text": [
"This was supported by analysis of the fluorescence emission spectra at 77 degrees K , chlorophyll a / b ratio , immunogold staining of the structures , and crystallographic unit size analysis ."
],
"offsets": [
[
0,
193
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3007 | split_0_train_3007 | [
{
"id": "split_0_train_3007_passage",
"type": "progene_text",
"text": [
"Development of a sandwich ELISA assay for measuring bovine soluble type II IL-1 receptor ( IL1R2 ) concentration in serum and milk ."
],
"offsets": [
[
0,
132
]
]
}
]
| [
{
"id": "split_0_train_4849_entity",
"type": "progene_text",
"text": [
"type II IL-1 receptor"
],
"offsets": [
[
67,
88
]
],
"normalized": []
},
{
"id": "split_0_train_4850_entity",
"type": "progene_text",
"text": [
"IL1R2"
],
"offsets": [
[
91,
96
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3008 | split_0_train_3008 | [
{
"id": "split_0_train_3008_passage",
"type": "progene_text",
"text": [
"The IL1R is composed of two kinds of molecule , type I ( IL1R I ) and type II ( IL1R2 ) ."
],
"offsets": [
[
0,
89
]
]
}
]
| [
{
"id": "split_0_train_4851_entity",
"type": "progene_text",
"text": [
"IL1R"
],
"offsets": [
[
4,
8
]
],
"normalized": []
},
{
"id": "split_0_train_4852_entity",
"type": "progene_text",
"text": [
"IL1R I"
],
"offsets": [
[
57,
63
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],
"normalized": []
},
{
"id": "split_0_train_4853_entity",
"type": "progene_text",
"text": [
"IL1R2"
],
"offsets": [
[
80,
85
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3009 | split_0_train_3009 | [
{
"id": "split_0_train_3009_passage",
"type": "progene_text",
"text": [
"IL1R1 contributes to IL-1 signaling , whereas the IL1R2 has no signaling property and acts as a decoy for IL-1 ."
],
"offsets": [
[
0,
112
]
]
}
]
| [
{
"id": "split_0_train_4854_entity",
"type": "progene_text",
"text": [
"IL1R1"
],
"offsets": [
[
0,
5
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],
"normalized": []
},
{
"id": "split_0_train_4855_entity",
"type": "progene_text",
"text": [
"IL-1"
],
"offsets": [
[
21,
25
]
],
"normalized": []
},
{
"id": "split_0_train_4856_entity",
"type": "progene_text",
"text": [
"IL1R2"
],
"offsets": [
[
50,
55
]
],
"normalized": []
},
{
"id": "split_0_train_4857_entity",
"type": "progene_text",
"text": [
"IL-1"
],
"offsets": [
[
106,
110
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3010 | split_0_train_3010 | [
{
"id": "split_0_train_3010_passage",
"type": "progene_text",
"text": [
"In this study , we developed a bovine IL1R2 - specific sandwich ELISA to examine the sIL1R2 concentration in serum and milk from dairy cows ."
],
"offsets": [
[
0,
141
]
]
}
]
| [
{
"id": "split_0_train_4858_entity",
"type": "progene_text",
"text": [
"IL1R2"
],
"offsets": [
[
38,
43
]
],
"normalized": []
},
{
"id": "split_0_train_4859_entity",
"type": "progene_text",
"text": [
"sIL1R2"
],
"offsets": [
[
85,
91
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3011 | split_0_train_3011 | [
{
"id": "split_0_train_3011_passage",
"type": "progene_text",
"text": [
"The concentration of colostral IL-1beta was examined to estimate the correlation to sIL1R2 ."
],
"offsets": [
[
0,
92
]
]
}
]
| [
{
"id": "split_0_train_4860_entity",
"type": "progene_text",
"text": [
"IL-1beta"
],
"offsets": [
[
31,
39
]
],
"normalized": []
},
{
"id": "split_0_train_4861_entity",
"type": "progene_text",
"text": [
"sIL1R2"
],
"offsets": [
[
84,
90
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3012 | split_0_train_3012 | [
{
"id": "split_0_train_3012_passage",
"type": "progene_text",
"text": [
"The results showed that the sIL1R2 concentration in sera and milk changes with the stages of lactation ."
],
"offsets": [
[
0,
104
]
]
}
]
| [
{
"id": "split_0_train_4862_entity",
"type": "progene_text",
"text": [
"sIL1R2"
],
"offsets": [
[
28,
34
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3013 | split_0_train_3013 | [
{
"id": "split_0_train_3013_passage",
"type": "progene_text",
"text": [
"The serum sIL1R2 concentrations were 5.56 +/- 0.69 ng / ml ( colostrum ) , 3.14 +/- 0.72 ng / ml ( the early stage of lactation ) and 5.76 +/- 1.25 ng / ml ( the late stage of lactation ) ."
],
"offsets": [
[
0,
189
]
]
}
]
| [
{
"id": "split_0_train_4863_entity",
"type": "progene_text",
"text": [
"sIL1R2"
],
"offsets": [
[
10,
16
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3014 | split_0_train_3014 | [
{
"id": "split_0_train_3014_passage",
"type": "progene_text",
"text": [
"The milk sIL1R2 concentrations were 1.83 +/- 0.47 ng / ml ( colostrum ) , 0.73 +/- 0.22 ng / ml ( the early stage of lactation ) and 2.92 +/- 0.56 ng / ml ( the late stage of lactation ) ."
],
"offsets": [
[
0,
188
]
]
}
]
| [
{
"id": "split_0_train_4864_entity",
"type": "progene_text",
"text": [
"sIL1R2"
],
"offsets": [
[
9,
15
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3015 | split_0_train_3015 | [
{
"id": "split_0_train_3015_passage",
"type": "progene_text",
"text": [
"The concentrations of IL1R2 in sera and milk were significantly higher at the late stage of lactation and colostrum than that of the early stage of lactation ."
],
"offsets": [
[
0,
159
]
]
}
]
| [
{
"id": "split_0_train_4865_entity",
"type": "progene_text",
"text": [
"IL1R2"
],
"offsets": [
[
22,
27
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3016 | split_0_train_3016 | [
{
"id": "split_0_train_3016_passage",
"type": "progene_text",
"text": [
"The reduction rates of sIL1R2 levels from the colostrum to the early stage of lactation were 43.6 % ( serum ) and 61 % ( whey ) ."
],
"offsets": [
[
0,
129
]
]
}
]
| [
{
"id": "split_0_train_4866_entity",
"type": "progene_text",
"text": [
"sIL1R2"
],
"offsets": [
[
23,
29
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3017 | split_0_train_3017 | [
{
"id": "split_0_train_3017_passage",
"type": "progene_text",
"text": [
"IL-1beta was detected in all the colostrum ( 995.9 +/- 346.6 ng / ml ) ."
],
"offsets": [
[
0,
72
]
]
}
]
| [
{
"id": "split_0_train_4867_entity",
"type": "progene_text",
"text": [
"IL-1beta"
],
"offsets": [
[
0,
8
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3018 | split_0_train_3018 | [
{
"id": "split_0_train_3018_passage",
"type": "progene_text",
"text": [
"Significant correlation was observed between the levels of colostral IL-1beta and IL1R2 ( r = 0.75 ) ."
],
"offsets": [
[
0,
102
]
]
}
]
| [
{
"id": "split_0_train_4868_entity",
"type": "progene_text",
"text": [
"IL-1beta"
],
"offsets": [
[
69,
77
]
],
"normalized": []
},
{
"id": "split_0_train_4869_entity",
"type": "progene_text",
"text": [
"IL1R2"
],
"offsets": [
[
82,
87
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3019 | split_0_train_3019 | [
{
"id": "split_0_train_3019_passage",
"type": "progene_text",
"text": [
"Screening of novel cellulose - degrading bacterium and its application to denitrification of groundwater ."
],
"offsets": [
[
0,
106
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3020 | split_0_train_3020 | [
{
"id": "split_0_train_3020_passage",
"type": "progene_text",
"text": [
"To establish an environmentally friendly groundwater bioremediation process using a cellulose carrier combined with cellulose - utilizing , denitrifying microorganisms , a novel psychrophilic bacterium , designated CL-5 , which can degrade a commercial - based cellulose carrier as the sole carbon source , was screened ."
],
"offsets": [
[
0,
321
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3021 | split_0_train_3021 | [
{
"id": "split_0_train_3021_passage",
"type": "progene_text",
"text": [
"Since the denitrification capability of CL-5 is low , complex microbial systems were constructed together with other denitrifying bacteria designated NR-1 and NR-2 that were also isolated from soil ."
],
"offsets": [
[
0,
199
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3022 | split_0_train_3022 | [
{
"id": "split_0_train_3022_passage",
"type": "progene_text",
"text": [
"The nitrate - reducing activities of mixed cultures were much higher than those of the pure cultures of CL-5 , NR-1 and NR-2 ."
],
"offsets": [
[
0,
126
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3023 | split_0_train_3023 | [
{
"id": "split_0_train_3023_passage",
"type": "progene_text",
"text": [
"The highest N(2)O and N(2) formation activities were observed in the mixed culture of CL-5+NR-2 ."
],
"offsets": [
[
0,
97
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3024 | split_0_train_3024 | [
{
"id": "split_0_train_3024_passage",
"type": "progene_text",
"text": [
"A genome - wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway ."
],
"offsets": [
[
0,
121
]
]
}
]
| [
{
"id": "split_0_train_4870_entity",
"type": "progene_text",
"text": [
"Hh"
],
"offsets": [
[
99,
101
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3025 | split_0_train_3025 | [
{
"id": "split_0_train_3025_passage",
"type": "progene_text",
"text": [
"Members of the Hedgehog ( Hh ) family of signaling proteins are powerful regulators of developmental processes in many organisms and have been implicated in many human disease states ."
],
"offsets": [
[
0,
184
]
]
}
]
| [
{
"id": "split_0_train_4871_entity",
"type": "progene_text",
"text": [
"Hedgehog ( Hh ) family"
],
"offsets": [
[
15,
37
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3026 | split_0_train_3026 | [
{
"id": "split_0_train_3026_passage",
"type": "progene_text",
"text": [
"Here we report the results of a genome - wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway ."
],
"offsets": [
[
0,
151
]
]
}
]
| [
{
"id": "split_0_train_4872_entity",
"type": "progene_text",
"text": [
"Hh"
],
"offsets": [
[
129,
131
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3027 | split_0_train_3027 | [
{
"id": "split_0_train_3027_passage",
"type": "progene_text",
"text": [
"The screen identified hundreds of potential new regulators of Hh signaling , including many large protein complexes with pleiotropic effects , such as the coat protein complex I ( COPI ) complex , the ribosome and the proteasome ."
],
"offsets": [
[
0,
230
]
]
}
]
| [
{
"id": "split_0_train_4873_entity",
"type": "progene_text",
"text": [
"Hh"
],
"offsets": [
[
62,
64
]
],
"normalized": []
},
{
"id": "split_0_train_4874_entity",
"type": "progene_text",
"text": [
"coat protein complex I"
],
"offsets": [
[
155,
177
]
],
"normalized": []
},
{
"id": "split_0_train_4875_entity",
"type": "progene_text",
"text": [
"COPI"
],
"offsets": [
[
180,
184
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3028 | split_0_train_3028 | [
{
"id": "split_0_train_3028_passage",
"type": "progene_text",
"text": [
"We identified the multimeric protein phosphatase 2A ( PP2A ) and two new kinases , the D. melanogaster orthologs of the vertebrate PITSLRE and cyclin - dependent kinase - 9 ( CDK9 ) kinases , as Hh regulators ."
],
"offsets": [
[
0,
210
]
]
}
]
| [
{
"id": "split_0_train_4876_entity",
"type": "progene_text",
"text": [
"protein phosphatase 2A"
],
"offsets": [
[
29,
51
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],
"normalized": []
},
{
"id": "split_0_train_4877_entity",
"type": "progene_text",
"text": [
"PP2A"
],
"offsets": [
[
54,
58
]
],
"normalized": []
},
{
"id": "split_0_train_4878_entity",
"type": "progene_text",
"text": [
"kinases"
],
"offsets": [
[
73,
80
]
],
"normalized": []
},
{
"id": "split_0_train_4879_entity",
"type": "progene_text",
"text": [
"PITSLRE"
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"offsets": [
[
131,
138
]
],
"normalized": []
},
{
"id": "split_0_train_4880_entity",
"type": "progene_text",
"text": [
"cyclin - dependent kinase - 9"
],
"offsets": [
[
143,
172
]
],
"normalized": []
},
{
"id": "split_0_train_4881_entity",
"type": "progene_text",
"text": [
"CDK9"
],
"offsets": [
[
175,
179
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],
"normalized": []
},
{
"id": "split_0_train_4882_entity",
"type": "progene_text",
"text": [
"kinases"
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"offsets": [
[
182,
189
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],
"normalized": []
},
{
"id": "split_0_train_4883_entity",
"type": "progene_text",
"text": [
"Hh"
],
"offsets": [
[
195,
197
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3029 | split_0_train_3029 | [
{
"id": "split_0_train_3029_passage",
"type": "progene_text",
"text": [
"We also identified a large group of constitutive and alternative splicing factors , two nucleoporins involved in mRNA export and several RNA - regulatory proteins as potent regulators of Hh signal transduction , indicating that splicing regulation and mRNA transport have a previously unrecognized role in Hh signaling ."
],
"offsets": [
[
0,
320
]
]
}
]
| [
{
"id": "split_0_train_4884_entity",
"type": "progene_text",
"text": [
"nucleoporins"
],
"offsets": [
[
88,
100
]
],
"normalized": []
},
{
"id": "split_0_train_4885_entity",
"type": "progene_text",
"text": [
"Hh"
],
"offsets": [
[
187,
189
]
],
"normalized": []
},
{
"id": "split_0_train_4886_entity",
"type": "progene_text",
"text": [
"Hh"
],
"offsets": [
[
306,
308
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3030 | split_0_train_3030 | [
{
"id": "split_0_train_3030_passage",
"type": "progene_text",
"text": [
"Finally , we showed that several of these genes have conserved roles in mammalian Hh signaling ."
],
"offsets": [
[
0,
96
]
]
}
]
| [
{
"id": "split_0_train_4887_entity",
"type": "progene_text",
"text": [
"Hh"
],
"offsets": [
[
82,
84
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3031 | split_0_train_3031 | [
{
"id": "split_0_train_3031_passage",
"type": "progene_text",
"text": [
"Molecular evolution of the AP2 subfamily ."
],
"offsets": [
[
0,
42
]
]
}
]
| [
{
"id": "split_0_train_4888_entity",
"type": "progene_text",
"text": [
"AP2 subfamily"
],
"offsets": [
[
27,
40
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3032 | split_0_train_3032 | [
{
"id": "split_0_train_3032_passage",
"type": "progene_text",
"text": [
"The AP2 ( APETALA2 ) / EREBP ( Ethylene Responsive Element Binding Protein ) multigene family includes developmentally and physiologically important transcription factors ."
],
"offsets": [
[
0,
172
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]
}
]
| [
{
"id": "split_0_train_4889_entity",
"type": "progene_text",
"text": [
"AP2 ( APETALA2 ) / EREBP ( Ethylene Responsive Element Binding Protein ) multigene family"
],
"offsets": [
[
4,
93
]
],
"normalized": []
},
{
"id": "split_0_train_4890_entity",
"type": "progene_text",
"text": [
"transcription factors"
],
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[
149,
170
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3033 | split_0_train_3033 | [
{
"id": "split_0_train_3033_passage",
"type": "progene_text",
"text": [
"AP2 / EREBP genes are divided into two subfamilies : AP2 genes with two AP2 domains and EREBP genes with a single AP2 / ERF ( Ethylene Responsive Element Binding Factor ) domain ."
],
"offsets": [
[
0,
179
]
]
}
]
| [
{
"id": "split_0_train_4891_entity",
"type": "progene_text",
"text": [
"AP2"
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"offsets": [
[
0,
3
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],
"normalized": []
},
{
"id": "split_0_train_4892_entity",
"type": "progene_text",
"text": [
"EREBP"
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[
6,
11
]
],
"normalized": []
},
{
"id": "split_0_train_4893_entity",
"type": "progene_text",
"text": [
"AP2"
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[
53,
56
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],
"normalized": []
},
{
"id": "split_0_train_4894_entity",
"type": "progene_text",
"text": [
"AP2"
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[
72,
75
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],
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},
{
"id": "split_0_train_4895_entity",
"type": "progene_text",
"text": [
"EREBP"
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[
88,
93
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],
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},
{
"id": "split_0_train_4896_entity",
"type": "progene_text",
"text": [
"AP2"
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[
114,
117
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],
"normalized": []
},
{
"id": "split_0_train_4897_entity",
"type": "progene_text",
"text": [
"ERF"
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"offsets": [
[
120,
123
]
],
"normalized": []
},
{
"id": "split_0_train_4898_entity",
"type": "progene_text",
"text": [
"Ethylene Responsive Element Binding Factor"
],
"offsets": [
[
126,
168
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3034 | split_0_train_3034 | [
{
"id": "split_0_train_3034_passage",
"type": "progene_text",
"text": [
"Based on previous phylogenetic analyses , AP2 genes can be divided into two clades , AP2 and ANT groups ."
],
"offsets": [
[
0,
105
]
]
}
]
| [
{
"id": "split_0_train_4899_entity",
"type": "progene_text",
"text": [
"AP2"
],
"offsets": [
[
42,
45
]
],
"normalized": []
},
{
"id": "split_0_train_4900_entity",
"type": "progene_text",
"text": [
"AP2 and ANT groups"
],
"offsets": [
[
85,
103
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3035 | split_0_train_3035 | [
{
"id": "split_0_train_3035_passage",
"type": "progene_text",
"text": [
"To clarify the molecular evolution of the AP2 subfamily , we isolated and sequenced genes with two AP2 domains from three gymnosperms , Cycas revoluta , Ginkgo biloba , and Gnetum parvifolium , as well as from the moss Physcomitrella patens ."
],
"offsets": [
[
0,
242
]
]
}
]
| [
{
"id": "split_0_train_4901_entity",
"type": "progene_text",
"text": [
"AP2 subfamily"
],
"offsets": [
[
42,
55
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],
"normalized": []
},
{
"id": "split_0_train_4902_entity",
"type": "progene_text",
"text": [
"AP2"
],
"offsets": [
[
99,
102
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3036 | split_0_train_3036 | [
{
"id": "split_0_train_3036_passage",
"type": "progene_text",
"text": [
"Expressions of AP2 - like genes , including AP2 , in Arabidopsis thaliana are regulated by the microRNA miR172 ."
],
"offsets": [
[
0,
112
]
]
}
]
| [
{
"id": "split_0_train_4903_entity",
"type": "progene_text",
"text": [
"AP2"
],
"offsets": [
[
15,
18
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],
"normalized": []
},
{
"id": "split_0_train_4904_entity",
"type": "progene_text",
"text": [
"AP2"
],
"offsets": [
[
44,
47
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3037 | split_0_train_3037 | [
{
"id": "split_0_train_3037_passage",
"type": "progene_text",
"text": [
"We found that the target site of miR172 is significantly conserved in gymnosperm AP2 homologs , suggesting that regulatory mechanisms of gene expression using microRNA have been conserved over the three hundred million years since the divergence of gymnosperm and flowering plant lineages ."
],
"offsets": [
[
0,
290
]
]
}
]
| [
{
"id": "split_0_train_4905_entity",
"type": "progene_text",
"text": [
"AP2"
],
"offsets": [
[
81,
84
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3038 | split_0_train_3038 | [
{
"id": "split_0_train_3038_passage",
"type": "progene_text",
"text": [
"We inferred a phylogenetic relationship of these genes with the green alga Chlamydomonas reinhardtii and seed - plant genes available in public DNA databases ."
],
"offsets": [
[
0,
159
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3039 | split_0_train_3039 | [
{
"id": "split_0_train_3039_passage",
"type": "progene_text",
"text": [
"The phylogenetic tree showed that the AP2 subfamily diverged into the AP2 and ANT groups before the last common ancestor of land plants and after C. reinhardtii diverged from the land - plant lineage ."
],
"offsets": [
[
0,
201
]
]
}
]
| [
{
"id": "split_0_train_4906_entity",
"type": "progene_text",
"text": [
"AP2 subfamily"
],
"offsets": [
[
38,
51
]
],
"normalized": []
},
{
"id": "split_0_train_4907_entity",
"type": "progene_text",
"text": [
"AP2 and ANT groups"
],
"offsets": [
[
70,
88
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3040 | split_0_train_3040 | [
{
"id": "split_0_train_3040_passage",
"type": "progene_text",
"text": [
"The tree also indicated that each AP2 and ANT group further diverged into several clades through gene duplications prior to the divergence of gymnosperms and angiosperms ."
],
"offsets": [
[
0,
171
]
]
}
]
| [
{
"id": "split_0_train_4908_entity",
"type": "progene_text",
"text": [
"AP2 and ANT group"
],
"offsets": [
[
34,
51
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3041 | split_0_train_3041 | [
{
"id": "split_0_train_3041_passage",
"type": "progene_text",
"text": [
"[ Renal failure secondary to effort rhabdomyolysis : report of three cases ]"
],
"offsets": [
[
0,
76
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3042 | split_0_train_3042 | [
{
"id": "split_0_train_3042_passage",
"type": "progene_text",
"text": [
"Renal failure secondary to effort rhabdomyolysis is uncommon ."
],
"offsets": [
[
0,
62
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3043 | split_0_train_3043 | [
{
"id": "split_0_train_3043_passage",
"type": "progene_text",
"text": [
"We report three males age 28 , 37 ( military sportsmen ) and 44 years ( sedentary obese ) , with this condition ."
],
"offsets": [
[
0,
113
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3044 | split_0_train_3044 | [
{
"id": "split_0_train_3044_passage",
"type": "progene_text",
"text": [
"Episodes occurred after a training session to run a triathlon , during the course of a mini marathon and during a rescue attempt of a drowning person ."
],
"offsets": [
[
0,
151
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3045 | split_0_train_3045 | [
{
"id": "split_0_train_3045_passage",
"type": "progene_text",
"text": [
"All three subjects experienced intense muscle symptoms , hemoglubinuria , oliguria , rise of blood urea nitrogen and a significant rise in muscle enzymes ."
],
"offsets": [
[
0,
155
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3046 | split_0_train_3046 | [
{
"id": "split_0_train_3046_passage",
"type": "progene_text",
"text": [
"Creatinekinase reached a maximum of 41 times normal , aspartate aminotransferase a maximum 35 times normal and lactacte dehydrogenase a maximum of 11 times normal ."
],
"offsets": [
[
0,
164
]
]
}
]
| [
{
"id": "split_0_train_4909_entity",
"type": "progene_text",
"text": [
"Creatinekinase"
],
"offsets": [
[
0,
14
]
],
"normalized": []
},
{
"id": "split_0_train_4910_entity",
"type": "progene_text",
"text": [
"aspartate aminotransferase"
],
"offsets": [
[
54,
80
]
],
"normalized": []
},
{
"id": "split_0_train_4911_entity",
"type": "progene_text",
"text": [
"lactacte dehydrogenase"
],
"offsets": [
[
111,
133
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3047 | split_0_train_3047 | [
{
"id": "split_0_train_3047_passage",
"type": "progene_text",
"text": [
"There was a rapid elevation of serum creatinine , reaching values of 6.6 and 9.8 mg / dl on the third day after the physical effort ."
],
"offsets": [
[
0,
133
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3048 | split_0_train_3048 | [
{
"id": "split_0_train_3048_passage",
"type": "progene_text",
"text": [
"This parameter had a disproportionate elevation in relation to urea nitrogen , in two subjects ."
],
"offsets": [
[
0,
96
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3049 | split_0_train_3049 | [
{
"id": "split_0_train_3049_passage",
"type": "progene_text",
"text": [
"All subjects were managed with saline hydration , sodium bicarbonate and furosemide ."
],
"offsets": [
[
0,
85
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3050 | split_0_train_3050 | [
{
"id": "split_0_train_3050_passage",
"type": "progene_text",
"text": [
"Only one required hemodialysis for two days ."
],
"offsets": [
[
0,
45
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3051 | split_0_train_3051 | [
{
"id": "split_0_train_3051_passage",
"type": "progene_text",
"text": [
"All normalized their renal function 18 to 48 days after the physical exertion ."
],
"offsets": [
[
0,
79
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3052 | split_0_train_3052 | [
{
"id": "split_0_train_3052_passage",
"type": "progene_text",
"text": [
"No subject had other predisposing conditions for acute renal failure ."
],
"offsets": [
[
0,
70
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3053 | split_0_train_3053 | [
{
"id": "split_0_train_3053_passage",
"type": "progene_text",
"text": [
"Affinity , kinetic , and structural study of the interaction of 3-O-sulfotransferase isoform 1 with heparan sulfate ."
],
"offsets": [
[
0,
117
]
]
}
]
| [
{
"id": "split_0_train_4912_entity",
"type": "progene_text",
"text": [
"3-O-sulfotransferase isoform 1"
],
"offsets": [
[
64,
94
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3054 | split_0_train_3054 | [
{
"id": "split_0_train_3054_passage",
"type": "progene_text",
"text": [
"The 3-O-sulfonation of glucosamine residues in heparan sulfate ( HS ) by 3-O-sulfotransferase ( 3-OST ) is a key substitution that is present in HS sequences of biological importance , in particular HS anticoagulant activity ."
],
"offsets": [
[
0,
226
]
]
}
]
| [
{
"id": "split_0_train_4913_entity",
"type": "progene_text",
"text": [
"3-O-sulfotransferase"
],
"offsets": [
[
73,
93
]
],
"normalized": []
},
{
"id": "split_0_train_4914_entity",
"type": "progene_text",
"text": [
"3-OST"
],
"offsets": [
[
96,
101
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3055 | split_0_train_3055 | [
{
"id": "split_0_train_3055_passage",
"type": "progene_text",
"text": [
"Six different isoforms of 3-OST have been identified that exhibit different substrate specificity ."
],
"offsets": [
[
0,
99
]
]
}
]
| [
{
"id": "split_0_train_4915_entity",
"type": "progene_text",
"text": [
"3-OST"
],
"offsets": [
[
26,
31
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3056 | split_0_train_3056 | [
{
"id": "split_0_train_3056_passage",
"type": "progene_text",
"text": [
"In this paper the affinity and kinetics of the interaction between 3-O-sulfotransferase isoform 1 ( 3-OST-1 ) and HS have been examined using surface plasmon resonance ( SPR ) ."
],
"offsets": [
[
0,
177
]
]
}
]
| [
{
"id": "split_0_train_4916_entity",
"type": "progene_text",
"text": [
"3-O-sulfotransferase isoform 1"
],
"offsets": [
[
67,
97
]
],
"normalized": []
},
{
"id": "split_0_train_4917_entity",
"type": "progene_text",
"text": [
"3-OST-1"
],
"offsets": [
[
100,
107
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3057 | split_0_train_3057 | [
{
"id": "split_0_train_3057_passage",
"type": "progene_text",
"text": [
"3-OST-1 binds with micomolar affinity to HS ( K(D) = 2.79 microM ) , and this interaction is apparently independent of the presence of the coenzyme , 3'-phosphoadenosine 5 '-phosphosulfate ( PAPS ) ."
],
"offsets": [
[
0,
199
]
]
}
]
| [
{
"id": "split_0_train_4918_entity",
"type": "progene_text",
"text": [
"3-OST-1"
],
"offsets": [
[
0,
7
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3058 | split_0_train_3058 | [
{
"id": "split_0_train_3058_passage",
"type": "progene_text",
"text": [
"A conformational change in the complex has also been detected , supporting data from previous studies ."
],
"offsets": [
[
0,
103
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3059 | split_0_train_3059 | [
{
"id": "split_0_train_3059_passage",
"type": "progene_text",
"text": [
"Selected 3-OST-1 mutants have provided valuable information of amino acid residues that participate in 3-OST-1 interaction with HS substrate and its catalytic activity ."
],
"offsets": [
[
0,
169
]
]
}
]
| [
{
"id": "split_0_train_4919_entity",
"type": "progene_text",
"text": [
"3-OST-1"
],
"offsets": [
[
9,
16
]
],
"normalized": []
},
{
"id": "split_0_train_4920_entity",
"type": "progene_text",
"text": [
"3-OST-1"
],
"offsets": [
[
103,
110
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3060 | split_0_train_3060 | [
{
"id": "split_0_train_3060_passage",
"type": "progene_text",
"text": [
"The results from this study contribute to understanding the substrate specificity among the 3-OST isoforms and in the mechanism of 3-OST-1 - catalyzed biosynthesis of anticoagulant HS ."
],
"offsets": [
[
0,
185
]
]
}
]
| [
{
"id": "split_0_train_4921_entity",
"type": "progene_text",
"text": [
"3-OST"
],
"offsets": [
[
92,
97
]
],
"normalized": []
},
{
"id": "split_0_train_4922_entity",
"type": "progene_text",
"text": [
"3-OST-1"
],
"offsets": [
[
131,
138
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3061 | split_0_train_3061 | [
{
"id": "split_0_train_3061_passage",
"type": "progene_text",
"text": [
"Avian and canine aldehyde oxidases ."
],
"offsets": [
[
0,
36
]
]
}
]
| [
{
"id": "split_0_train_4923_entity",
"type": "progene_text",
"text": [
"aldehyde oxidases"
],
"offsets": [
[
17,
34
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3062 | split_0_train_3062 | [
{
"id": "split_0_train_3062_passage",
"type": "progene_text",
"text": [
"Novel insights into the biology and evolution of molybdo - flavoenzymes ."
],
"offsets": [
[
0,
73
]
]
}
]
| [
{
"id": "split_0_train_4924_entity",
"type": "progene_text",
"text": [
"molybdo - flavoenzymes"
],
"offsets": [
[
49,
71
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3063 | split_0_train_3063 | [
{
"id": "split_0_train_3063_passage",
"type": "progene_text",
"text": [
"Aldehyde oxidases are molybdo - flavoenzymes structurally related to xanthine oxidoreductase ."
],
"offsets": [
[
0,
94
]
]
}
]
| [
{
"id": "split_0_train_4925_entity",
"type": "progene_text",
"text": [
"Aldehyde oxidases"
],
"offsets": [
[
0,
17
]
],
"normalized": []
},
{
"id": "split_0_train_4926_entity",
"type": "progene_text",
"text": [
"molybdo - flavoenzymes"
],
"offsets": [
[
22,
44
]
],
"normalized": []
},
{
"id": "split_0_train_4927_entity",
"type": "progene_text",
"text": [
"xanthine oxidoreductase"
],
"offsets": [
[
69,
92
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3064 | split_0_train_3064 | [
{
"id": "split_0_train_3064_passage",
"type": "progene_text",
"text": [
"They catalyze the oxidation of aldehydes or N-heterocycles of physiological , pharmacological , and toxicological relevance ."
],
"offsets": [
[
0,
125
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3065 | split_0_train_3065 | [
{
"id": "split_0_train_3065_passage",
"type": "progene_text",
"text": [
"Rodents are characterized by four aldehyde oxidases as follows : AOX1 and aldehyde oxidase homologs 1-3 ( AOH1 , AOH2 , and AOH3 ) ."
],
"offsets": [
[
0,
132
]
]
}
]
| [
{
"id": "split_0_train_4928_entity",
"type": "progene_text",
"text": [
"aldehyde oxidases"
],
"offsets": [
[
34,
51
]
],
"normalized": []
},
{
"id": "split_0_train_4929_entity",
"type": "progene_text",
"text": [
"AOX1"
],
"offsets": [
[
65,
69
]
],
"normalized": []
},
{
"id": "split_0_train_4930_entity",
"type": "progene_text",
"text": [
"aldehyde oxidase homologs 1-3"
],
"offsets": [
[
74,
103
]
],
"normalized": []
},
{
"id": "split_0_train_4931_entity",
"type": "progene_text",
"text": [
"AOH1"
],
"offsets": [
[
106,
110
]
],
"normalized": []
},
{
"id": "split_0_train_4932_entity",
"type": "progene_text",
"text": [
"AOH2"
],
"offsets": [
[
113,
117
]
],
"normalized": []
},
{
"id": "split_0_train_4933_entity",
"type": "progene_text",
"text": [
"AOH3"
],
"offsets": [
[
124,
128
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3066 | split_0_train_3066 | [
{
"id": "split_0_train_3066_passage",
"type": "progene_text",
"text": [
"Humans synthesize a single functional aldehyde oxidase , AOX1 ."
],
"offsets": [
[
0,
63
]
]
}
]
| [
{
"id": "split_0_train_4934_entity",
"type": "progene_text",
"text": [
"aldehyde oxidase"
],
"offsets": [
[
38,
54
]
],
"normalized": []
},
{
"id": "split_0_train_4935_entity",
"type": "progene_text",
"text": [
"AOX1"
],
"offsets": [
[
57,
61
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3067 | split_0_train_3067 | [
{
"id": "split_0_train_3067_passage",
"type": "progene_text",
"text": [
"Here we define the structure and the characteristics of the aldehyde oxidase genes and proteins in chicken and dog ."
],
"offsets": [
[
0,
116
]
]
}
]
| [
{
"id": "split_0_train_4936_entity",
"type": "progene_text",
"text": [
"aldehyde oxidase"
],
"offsets": [
[
60,
76
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3068 | split_0_train_3068 | [
{
"id": "split_0_train_3068_passage",
"type": "progene_text",
"text": [
"The avian genome contains two aldehyde oxidase genes , AOX1 and AOH , mapping to chromosome 7 ."
],
"offsets": [
[
0,
95
]
]
}
]
| [
{
"id": "split_0_train_4937_entity",
"type": "progene_text",
"text": [
"aldehyde oxidase"
],
"offsets": [
[
30,
46
]
],
"normalized": []
},
{
"id": "split_0_train_4938_entity",
"type": "progene_text",
"text": [
"AOX1"
],
"offsets": [
[
55,
59
]
],
"normalized": []
},
{
"id": "split_0_train_4939_entity",
"type": "progene_text",
"text": [
"AOH"
],
"offsets": [
[
64,
67
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3069 | split_0_train_3069 | [
{
"id": "split_0_train_3069_passage",
"type": "progene_text",
"text": [
"AOX1 and AOH are structurally very similar and code for proteins whose sequence was deduced from the corresponding cDNAs ."
],
"offsets": [
[
0,
122
]
]
}
]
| [
{
"id": "split_0_train_4940_entity",
"type": "progene_text",
"text": [
"AOX1"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_4941_entity",
"type": "progene_text",
"text": [
"AOH"
],
"offsets": [
[
9,
12
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3070 | split_0_train_3070 | [
{
"id": "split_0_train_3070_passage",
"type": "progene_text",
"text": [
"AOX1 is the ortholog of the same gene in mammals , whereas AOH represents the likely ancestor of rodent AOH1 , AOH2 , and AOH3 ."
],
"offsets": [
[
0,
128
]
]
}
]
| [
{
"id": "split_0_train_4942_entity",
"type": "progene_text",
"text": [
"AOX1"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_4943_entity",
"type": "progene_text",
"text": [
"AOH"
],
"offsets": [
[
59,
62
]
],
"normalized": []
},
{
"id": "split_0_train_4944_entity",
"type": "progene_text",
"text": [
"AOH1"
],
"offsets": [
[
104,
108
]
],
"normalized": []
},
{
"id": "split_0_train_4945_entity",
"type": "progene_text",
"text": [
"AOH2"
],
"offsets": [
[
111,
115
]
],
"normalized": []
},
{
"id": "split_0_train_4946_entity",
"type": "progene_text",
"text": [
"AOH3"
],
"offsets": [
[
122,
126
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3071 | split_0_train_3071 | [
{
"id": "split_0_train_3071_passage",
"type": "progene_text",
"text": [
"The dog genome is endowed with two structurally conserved and active aldehyde oxidases clustering on chromosome 37 ."
],
"offsets": [
[
0,
116
]
]
}
]
| [
{
"id": "split_0_train_4947_entity",
"type": "progene_text",
"text": [
"aldehyde oxidases"
],
"offsets": [
[
69,
86
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3072 | split_0_train_3072 | [
{
"id": "split_0_train_3072_passage",
"type": "progene_text",
"text": [
"Cloning of the corresponding cDNAs and tissue distribution studies demonstrate that they are the orthologs of rodent AOH2 and AOH3 ."
],
"offsets": [
[
0,
132
]
]
}
]
| [
{
"id": "split_0_train_4948_entity",
"type": "progene_text",
"text": [
"AOH2"
],
"offsets": [
[
117,
121
]
],
"normalized": []
},
{
"id": "split_0_train_4949_entity",
"type": "progene_text",
"text": [
"AOH3"
],
"offsets": [
[
126,
130
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3073 | split_0_train_3073 | [
{
"id": "split_0_train_3073_passage",
"type": "progene_text",
"text": [
"The vestiges of dog AOX1 and AOH1 are recognizable upstream of AOH2 and AOH3 on the same chromosome ."
],
"offsets": [
[
0,
101
]
]
}
]
| [
{
"id": "split_0_train_4950_entity",
"type": "progene_text",
"text": [
"AOX1"
],
"offsets": [
[
20,
24
]
],
"normalized": []
},
{
"id": "split_0_train_4951_entity",
"type": "progene_text",
"text": [
"AOH1"
],
"offsets": [
[
29,
33
]
],
"normalized": []
},
{
"id": "split_0_train_4952_entity",
"type": "progene_text",
"text": [
"AOH2"
],
"offsets": [
[
63,
67
]
],
"normalized": []
},
{
"id": "split_0_train_4953_entity",
"type": "progene_text",
"text": [
"AOH3"
],
"offsets": [
[
72,
76
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3074 | split_0_train_3074 | [
{
"id": "split_0_train_3074_passage",
"type": "progene_text",
"text": [
"Comparison of the complement and the structure of the aldehyde oxidase and xanthine oxidoreductase genes in vertebrates and other animal species indicates that they evolved through a series of duplication and inactivation events ."
],
"offsets": [
[
0,
230
]
]
}
]
| [
{
"id": "split_0_train_4954_entity",
"type": "progene_text",
"text": [
"aldehyde oxidase"
],
"offsets": [
[
54,
70
]
],
"normalized": []
},
{
"id": "split_0_train_4955_entity",
"type": "progene_text",
"text": [
"xanthine oxidoreductase"
],
"offsets": [
[
75,
98
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3075 | split_0_train_3075 | [
{
"id": "split_0_train_3075_passage",
"type": "progene_text",
"text": [
"Purification of the chicken AOX1 protein to homogeneity from kidney demonstrates that the enzyme possesses retinaldehyde oxidase activity ."
],
"offsets": [
[
0,
139
]
]
}
]
| [
{
"id": "split_0_train_4956_entity",
"type": "progene_text",
"text": [
"AOX1"
],
"offsets": [
[
28,
32
]
],
"normalized": []
},
{
"id": "split_0_train_4957_entity",
"type": "progene_text",
"text": [
"oxidase"
],
"offsets": [
[
121,
128
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3076 | split_0_train_3076 | [
{
"id": "split_0_train_3076_passage",
"type": "progene_text",
"text": [
"Unlike humans and most other mammals , dog and chicken are devoid of liver aldehyde oxidase activity ."
],
"offsets": [
[
0,
102
]
]
}
]
| [
{
"id": "split_0_train_4958_entity",
"type": "progene_text",
"text": [
"aldehyde oxidase"
],
"offsets": [
[
75,
91
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3077 | split_0_train_3077 | [
{
"id": "split_0_train_3077_passage",
"type": "progene_text",
"text": [
"An approach to analyze mechanisms of intestinal adaptation following total proctocolectomy ."
],
"offsets": [
[
0,
92
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3078 | split_0_train_3078 | [
{
"id": "split_0_train_3078_passage",
"type": "progene_text",
"text": [
"We hypothesized that epithelial cells of the remnant small intestine display \" colonic \" phenotype after total proctocolectomy ."
],
"offsets": [
[
0,
128
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3079 | split_0_train_3079 | [
{
"id": "split_0_train_3079_passage",
"type": "progene_text",
"text": [
"The aims of the present study were to identify preferentially expressed molecules in the colon or in the small intestine and to evaluate mRNA levels of those in the ileal pouch ."
],
"offsets": [
[
0,
178
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3080 | split_0_train_3080 | [
{
"id": "split_0_train_3080_passage",
"type": "progene_text",
"text": [
"Differential gene expression was investigated between the small intestine and the colon by using cDNA microarray and was confirmed by Northern blotting ."
],
"offsets": [
[
0,
153
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3081 | split_0_train_3081 | [
{
"id": "split_0_train_3081_passage",
"type": "progene_text",
"text": [
"Expression of three colonic mRNAs ( 3-hydroxy-3-methylglutaryl-coenzyme A synthase 2 , deleted malignant brain tumors 1 , carcinoembryonic antigen - related cell adhesion molecule 1 ) and one \" small intestinal \" ( microsomal triglyceride transfer protein ) mRNA were compared between the control and the ileal pouch mucosae by quantitative reverse transcriptase - polymerase chain reaction ."
],
"offsets": [
[
0,
392
]
]
}
]
| [
{
"id": "split_0_train_4959_entity",
"type": "progene_text",
"text": [
"3-hydroxy-3-methylglutaryl-coenzyme A synthase 2"
],
"offsets": [
[
36,
84
]
],
"normalized": []
},
{
"id": "split_0_train_4960_entity",
"type": "progene_text",
"text": [
"deleted malignant brain tumors 1"
],
"offsets": [
[
87,
119
]
],
"normalized": []
},
{
"id": "split_0_train_4961_entity",
"type": "progene_text",
"text": [
"carcinoembryonic antigen - related cell adhesion molecule 1"
],
"offsets": [
[
122,
181
]
],
"normalized": []
},
{
"id": "split_0_train_4962_entity",
"type": "progene_text",
"text": [
"microsomal triglyceride transfer protein"
],
"offsets": [
[
215,
255
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3082 | split_0_train_3082 | [
{
"id": "split_0_train_3082_passage",
"type": "progene_text",
"text": [
"Seventy - four clones were differentially expressed with more than a threefold difference ."
],
"offsets": [
[
0,
91
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3083 | split_0_train_3083 | [
{
"id": "split_0_train_3083_passage",
"type": "progene_text",
"text": [
"Differential expression was confirmed in all mRNAs examined , including 3-hydroxy-3-methylglutaryl-coenzyme A synthase 2 and microsomal triglyceride transfer protein ."
],
"offsets": [
[
0,
167
]
]
}
]
| [
{
"id": "split_0_train_4963_entity",
"type": "progene_text",
"text": [
"3-hydroxy-3-methylglutaryl-coenzyme A synthase 2"
],
"offsets": [
[
72,
120
]
],
"normalized": []
},
{
"id": "split_0_train_4964_entity",
"type": "progene_text",
"text": [
"microsomal triglyceride transfer protein"
],
"offsets": [
[
125,
165
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3084 | split_0_train_3084 | [
{
"id": "split_0_train_3084_passage",
"type": "progene_text",
"text": [
"The mucosal expression of carcinoembryonic antigen - related cell adhesion molecule 1 mRNA in the ileal pouch was enhanced in humans ."
],
"offsets": [
[
0,
134
]
]
}
]
| [
{
"id": "split_0_train_4965_entity",
"type": "progene_text",
"text": [
"carcinoembryonic antigen - related cell adhesion molecule 1"
],
"offsets": [
[
26,
85
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3085 | split_0_train_3085 | [
{
"id": "split_0_train_3085_passage",
"type": "progene_text",
"text": [
"The remnant ileum develops some , but not all , colonic phenotype after total proctocolectomy ."
],
"offsets": [
[
0,
95
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3086 | split_0_train_3086 | [
{
"id": "split_0_train_3086_passage",
"type": "progene_text",
"text": [
"Comparative study of epithelial gene expression between the small intestine and the colon enables us to analyze mechanisms of intestinal adaptation after total proctocolectomy ."
],
"offsets": [
[
0,
177
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3087 | split_0_train_3087 | [
{
"id": "split_0_train_3087_passage",
"type": "progene_text",
"text": [
"Subunit composition of a large xylanolytic complex ( xylanosome ) from Streptomyces olivaceoviridis E-86 ."
],
"offsets": [
[
0,
106
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3088 | split_0_train_3088 | [
{
"id": "split_0_train_3088_passage",
"type": "progene_text",
"text": [
"A xylanolytic complex ( xylanosome ) was isolated from Streptomyces olivaceoviridis E-86 grown on corncob xylan ."
],
"offsets": [
[
0,
113
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3089 | split_0_train_3089 | [
{
"id": "split_0_train_3089_passage",
"type": "progene_text",
"text": [
"The isolated xylanosome exhibited a high molecular mass of approximately 3.8 x 10(7) Da ( weight average ) using size exclusion chromatography / multi - angle laser light scattering ( SEC / MALLS ) , and was composed of at least 8 subunits with a mass range from 12 to 60 kDa ."
],
"offsets": [
[
0,
277
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3090 | split_0_train_3090 | [
{
"id": "split_0_train_3090_passage",
"type": "progene_text",
"text": [
"When a SDS-polyacrylamide gel zymogram was examined , the subunits of 47 , 35 , 32 , and 23 kDa were found to have xylanase activity , while the 30 - kDa subunit had CMCase activity ."
],
"offsets": [
[
0,
183
]
]
}
]
| [
{
"id": "split_0_train_4966_entity",
"type": "progene_text",
"text": [
"xylanase"
],
"offsets": [
[
115,
123
]
],
"normalized": []
},
{
"id": "split_0_train_4967_entity",
"type": "progene_text",
"text": [
"CMCase"
],
"offsets": [
[
166,
172
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3091 | split_0_train_3091 | [
{
"id": "split_0_train_3091_passage",
"type": "progene_text",
"text": [
"According to N - terminal sequence analyses , the 47 - and 23 - kDa subunits were found to be identical to the two reported xylanases , namely FXYN and GXYN , of S. olivaceoviridis E-86 ."
],
"offsets": [
[
0,
187
]
]
}
]
| [
{
"id": "split_0_train_4968_entity",
"type": "progene_text",
"text": [
"xylanases"
],
"offsets": [
[
124,
133
]
],
"normalized": []
},
{
"id": "split_0_train_4969_entity",
"type": "progene_text",
"text": [
"FXYN"
],
"offsets": [
[
143,
147
]
],
"normalized": []
},
{
"id": "split_0_train_4970_entity",
"type": "progene_text",
"text": [
"GXYN"
],
"offsets": [
[
152,
156
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3092 | split_0_train_3092 | [
{
"id": "split_0_train_3092_passage",
"type": "progene_text",
"text": [
"Both the 35 - and 32 - kDa subunits were found to be truncated forms of the intact FXYN xylanase that possibly resulted from the degradation by proteases ."
],
"offsets": [
[
0,
155
]
]
}
]
| [
{
"id": "split_0_train_4971_entity",
"type": "progene_text",
"text": [
"FXYN xylanase"
],
"offsets": [
[
83,
96
]
],
"normalized": []
},
{
"id": "split_0_train_4972_entity",
"type": "progene_text",
"text": [
"proteases"
],
"offsets": [
[
144,
153
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3093 | split_0_train_3093 | [
{
"id": "split_0_train_3093_passage",
"type": "progene_text",
"text": [
"The 15 - kDa subunit consisted solely the xylan - binding domain of the FXYN xylanase ."
],
"offsets": [
[
0,
87
]
]
}
]
| [
{
"id": "split_0_train_4973_entity",
"type": "progene_text",
"text": [
"FXYN xylanase"
],
"offsets": [
[
72,
85
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3094 | split_0_train_3094 | [
{
"id": "split_0_train_3094_passage",
"type": "progene_text",
"text": [
"The purified xylanosome appeared to bind partially to xylan and poorly to Avicel ."
],
"offsets": [
[
0,
82
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3095 | split_0_train_3095 | [
{
"id": "split_0_train_3095_passage",
"type": "progene_text",
"text": [
"Evolutionary history of the Asr gene family ."
],
"offsets": [
[
0,
45
]
]
}
]
| [
{
"id": "split_0_train_4974_entity",
"type": "progene_text",
"text": [
"Asr gene family"
],
"offsets": [
[
28,
43
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3096 | split_0_train_3096 | [
{
"id": "split_0_train_3096_passage",
"type": "progene_text",
"text": [
"The Asr gene family is widespread in higher plants ."
],
"offsets": [
[
0,
52
]
]
}
]
| [
{
"id": "split_0_train_4975_entity",
"type": "progene_text",
"text": [
"Asr gene family"
],
"offsets": [
[
4,
19
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3097 | split_0_train_3097 | [
{
"id": "split_0_train_3097_passage",
"type": "progene_text",
"text": [
"Most Asr genes are up - regulated under different environmental stress conditions and during fruit ripening ."
],
"offsets": [
[
0,
109
]
]
}
]
| [
{
"id": "split_0_train_4976_entity",
"type": "progene_text",
"text": [
"Asr"
],
"offsets": [
[
5,
8
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3098 | split_0_train_3098 | [
{
"id": "split_0_train_3098_passage",
"type": "progene_text",
"text": [
"ASR proteins are localized in the nucleus and their likely function is transcriptional regulation ."
],
"offsets": [
[
0,
99
]
]
}
]
| [
{
"id": "split_0_train_4977_entity",
"type": "progene_text",
"text": [
"ASR"
],
"offsets": [
[
0,
3
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3099 | split_0_train_3099 | [
{
"id": "split_0_train_3099_passage",
"type": "progene_text",
"text": [
"In cultivated tomato , we identified a novel fourth family member , named Asr4 , which maps close to its sibling genes Asr1 - Asr2 - Asr3 and displays an unshared region coding for a domain containing a 13 - amino acid repeat ."
],
"offsets": [
[
0,
227
]
]
}
]
| [
{
"id": "split_0_train_4978_entity",
"type": "progene_text",
"text": [
"Asr4"
],
"offsets": [
[
74,
78
]
],
"normalized": []
},
{
"id": "split_0_train_4979_entity",
"type": "progene_text",
"text": [
"Asr1"
],
"offsets": [
[
119,
123
]
],
"normalized": []
},
{
"id": "split_0_train_4980_entity",
"type": "progene_text",
"text": [
"Asr2"
],
"offsets": [
[
126,
130
]
],
"normalized": []
},
{
"id": "split_0_train_4981_entity",
"type": "progene_text",
"text": [
"Asr3"
],
"offsets": [
[
133,
137
]
],
"normalized": []
}
]
| []
| []
| []
|
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