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stringlengths 15
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list | entities
list | events
list | coreferences
list | relations
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split_0_train_3200 | split_0_train_3200 | [
{
"id": "split_0_train_3200_passage",
"type": "progene_text",
"text": [
"CONCLUSION :"
],
"offsets": [
[
0,
12
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3201 | split_0_train_3201 | [
{
"id": "split_0_train_3201_passage",
"type": "progene_text",
"text": [
"In our study only 19 patients were free of demonstrable thrombophilia risk factor ."
],
"offsets": [
[
0,
83
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3202 | split_0_train_3202 | [
{
"id": "split_0_train_3202_passage",
"type": "progene_text",
"text": [
"In 51 subjects a single risk factor was identified and in 53 multiple ( from 2 to 5 ) risk factors were identified ."
],
"offsets": [
[
0,
116
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3203 | split_0_train_3203 | [
{
"id": "split_0_train_3203_passage",
"type": "progene_text",
"text": [
"In our opinion a Laboratory assessment of thrombophilia risk factors after a previous episode of deep venous thrombosis is a diagnostic tool of great importance ."
],
"offsets": [
[
0,
162
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3204 | split_0_train_3204 | [
{
"id": "split_0_train_3204_passage",
"type": "progene_text",
"text": [
"As a matter of fact , in our experience , by using a standard analytical panel , it was possible to highlight one or more risk factors in about 85 % of the patients considered ."
],
"offsets": [
[
0,
177
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3205 | split_0_train_3205 | [
{
"id": "split_0_train_3205_passage",
"type": "progene_text",
"text": [
"Human adipose tissue macrophages are of an anti - inflammatory phenotype but capable of excessive pro - inflammatory mediator production ."
],
"offsets": [
[
0,
138
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3206 | split_0_train_3206 | [
{
"id": "split_0_train_3206_passage",
"type": "progene_text",
"text": [
"OBJECTIVE :"
],
"offsets": [
[
0,
11
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3207 | split_0_train_3207 | [
{
"id": "split_0_train_3207_passage",
"type": "progene_text",
"text": [
"Obesity is associated with a chronic low - grade inflammation and an increased abundance of macrophages in adipose tissue ."
],
"offsets": [
[
0,
123
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3208 | split_0_train_3208 | [
{
"id": "split_0_train_3208_passage",
"type": "progene_text",
"text": [
"Adipose tissue macrophages ( ATMs ) are assumed to interfere with adipocyte function leading to insulin resistance , thereby contributing to the pathogenesis of type 2 diabetes mellitus ."
],
"offsets": [
[
0,
187
]
]
}
]
| [
{
"id": "split_0_train_5188_entity",
"type": "progene_text",
"text": [
"insulin"
],
"offsets": [
[
96,
103
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3209 | split_0_train_3209 | [
{
"id": "split_0_train_3209_passage",
"type": "progene_text",
"text": [
"Macrophages exist in separate types of differentiation , but the nature of ATMs is largely unknown ."
],
"offsets": [
[
0,
100
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3210 | split_0_train_3210 | [
{
"id": "split_0_train_3210_passage",
"type": "progene_text",
"text": [
"DESIGN AND MEASUREMENTS :"
],
"offsets": [
[
0,
25
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3211 | split_0_train_3211 | [
{
"id": "split_0_train_3211_passage",
"type": "progene_text",
"text": [
"Stromal vascular cells ( SVCs ) and ATMs were isolated from human adipose tissues from different locations ."
],
"offsets": [
[
0,
108
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3212 | split_0_train_3212 | [
{
"id": "split_0_train_3212_passage",
"type": "progene_text",
"text": [
"We characterized ATMs phenotypically and functionally by flow cytometry , endocytosis assay and determination of secreted cytokines ."
],
"offsets": [
[
0,
133
]
]
}
]
| [
{
"id": "split_0_train_5189_entity",
"type": "progene_text",
"text": [
"cytokines"
],
"offsets": [
[
122,
131
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3213 | split_0_train_3213 | [
{
"id": "split_0_train_3213_passage",
"type": "progene_text",
"text": [
"For comparison , we used macrophages of the 'classical' ( M1 ) and the ' alternative ' , anti - inflammatory ( M2 ) type differentiated in vitro from peripheral blood monocytes ."
],
"offsets": [
[
0,
178
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3214 | split_0_train_3214 | [
{
"id": "split_0_train_3214_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3215 | split_0_train_3215 | [
{
"id": "split_0_train_3215_passage",
"type": "progene_text",
"text": [
"Like prototypic M2 macrophages , ATMs expressed considerable amounts of mannose receptor , haemoglobin scavenger receptor CD163 and integrin alphavbeta5 ."
],
"offsets": [
[
0,
154
]
]
}
]
| [
{
"id": "split_0_train_5190_entity",
"type": "progene_text",
"text": [
"mannose receptor"
],
"offsets": [
[
72,
88
]
],
"normalized": []
},
{
"id": "split_0_train_5191_entity",
"type": "progene_text",
"text": [
"haemoglobin scavenger receptor"
],
"offsets": [
[
91,
121
]
],
"normalized": []
},
{
"id": "split_0_train_5192_entity",
"type": "progene_text",
"text": [
"CD163"
],
"offsets": [
[
122,
127
]
],
"normalized": []
},
{
"id": "split_0_train_5193_entity",
"type": "progene_text",
"text": [
"integrin alphavbeta5"
],
"offsets": [
[
132,
152
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3216 | split_0_train_3216 | [
{
"id": "split_0_train_3216_passage",
"type": "progene_text",
"text": [
"The number of cells expressing these molecules correlated significantly with the donors ' body mass indices ( BMIs ) ."
],
"offsets": [
[
0,
118
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3217 | split_0_train_3217 | [
{
"id": "split_0_train_3217_passage",
"type": "progene_text",
"text": [
"Notably , SVCs positive for the common monocyte / macrophage marker CD14 contained a considerable fraction of blood monocytes , the abundance of which did not correlate with the BMIs , pointing to the requirement of the surface markers identified here for the identification of ATMs ."
],
"offsets": [
[
0,
284
]
]
}
]
| [
{
"id": "split_0_train_5194_entity",
"type": "progene_text",
"text": [
"CD14"
],
"offsets": [
[
68,
72
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3218 | split_0_train_3218 | [
{
"id": "split_0_train_3218_passage",
"type": "progene_text",
"text": [
"ATMs showed endocytic activities similar to M2 macrophages and accordingly secreted high amounts of IL-10 and IL-1 receptor antagonist ."
],
"offsets": [
[
0,
136
]
]
}
]
| [
{
"id": "split_0_train_5195_entity",
"type": "progene_text",
"text": [
"IL-10"
],
"offsets": [
[
100,
105
]
],
"normalized": []
},
{
"id": "split_0_train_5196_entity",
"type": "progene_text",
"text": [
"IL-1 receptor antagonist"
],
"offsets": [
[
110,
134
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3219 | split_0_train_3219 | [
{
"id": "split_0_train_3219_passage",
"type": "progene_text",
"text": [
"However , basal and induced secretion of pro - inflammatory mediators TNF-alpha , IL-6 , IL-1 , MCP-1 and MIP-1alpha was even higher in ATMs than in pro - inflammatory M1 macrophages ."
],
"offsets": [
[
0,
184
]
]
}
]
| [
{
"id": "split_0_train_5197_entity",
"type": "progene_text",
"text": [
"TNF-alpha"
],
"offsets": [
[
70,
79
]
],
"normalized": []
},
{
"id": "split_0_train_5198_entity",
"type": "progene_text",
"text": [
"IL-6"
],
"offsets": [
[
82,
86
]
],
"normalized": []
},
{
"id": "split_0_train_5199_entity",
"type": "progene_text",
"text": [
"IL-1"
],
"offsets": [
[
89,
93
]
],
"normalized": []
},
{
"id": "split_0_train_5200_entity",
"type": "progene_text",
"text": [
"MCP-1"
],
"offsets": [
[
96,
101
]
],
"normalized": []
},
{
"id": "split_0_train_5201_entity",
"type": "progene_text",
"text": [
"MIP-1alpha"
],
"offsets": [
[
106,
116
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3220 | split_0_train_3220 | [
{
"id": "split_0_train_3220_passage",
"type": "progene_text",
"text": [
"CONCLUSION :"
],
"offsets": [
[
0,
12
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3221 | split_0_train_3221 | [
{
"id": "split_0_train_3221_passage",
"type": "progene_text",
"text": [
"ATMs comprise a particular macrophage type that is M2 - like by surface marker expression , but they are competent to produce extensive amounts of inflammatory cytokines , which could considerably contribute to the development of insulin resistance ."
],
"offsets": [
[
0,
250
]
]
}
]
| [
{
"id": "split_0_train_5202_entity",
"type": "progene_text",
"text": [
"cytokines"
],
"offsets": [
[
160,
169
]
],
"normalized": []
},
{
"id": "split_0_train_5203_entity",
"type": "progene_text",
"text": [
"insulin"
],
"offsets": [
[
230,
237
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3222 | split_0_train_3222 | [
{
"id": "split_0_train_3222_passage",
"type": "progene_text",
"text": [
"Expression and selective up - regulation of toxin - related mono ADP-ribosyltransferases by pathogen - associated molecular patterns in alveolar epithelial cells ."
],
"offsets": [
[
0,
163
]
]
}
]
| [
{
"id": "split_0_train_5204_entity",
"type": "progene_text",
"text": [
"mono ADP-ribosyltransferases"
],
"offsets": [
[
60,
88
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3223 | split_0_train_3223 | [
{
"id": "split_0_train_3223_passage",
"type": "progene_text",
"text": [
"Mono ADP-ribosyltransferases ( ARTs ) are a family of enzymes related to bacterial toxins that possess adenosine diphosphate ribosyltransferase activity ."
],
"offsets": [
[
0,
154
]
]
}
]
| [
{
"id": "split_0_train_5205_entity",
"type": "progene_text",
"text": [
"Mono ADP-ribosyltransferases"
],
"offsets": [
[
0,
28
]
],
"normalized": []
},
{
"id": "split_0_train_5206_entity",
"type": "progene_text",
"text": [
"ARTs"
],
"offsets": [
[
31,
35
]
],
"normalized": []
},
{
"id": "split_0_train_5207_entity",
"type": "progene_text",
"text": [
"adenosine diphosphate ribosyltransferase"
],
"offsets": [
[
103,
143
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3224 | split_0_train_3224 | [
{
"id": "split_0_train_3224_passage",
"type": "progene_text",
"text": [
"We have assessed that A549 constitutively expressed ART1 on the cell surface and shown that lipotheicoic acid ( LTA ) and flagellin , but not lipopolysaccharide ( LPS ) , peptidoglycan ( PG ) and poly ( I : C ) , up - regulate ART1 in a time and dose dependent manner ."
],
"offsets": [
[
0,
269
]
]
}
]
| [
{
"id": "split_0_train_5208_entity",
"type": "progene_text",
"text": [
"ART1"
],
"offsets": [
[
52,
56
]
],
"normalized": []
},
{
"id": "split_0_train_5209_entity",
"type": "progene_text",
"text": [
"flagellin"
],
"offsets": [
[
122,
131
]
],
"normalized": []
},
{
"id": "split_0_train_5210_entity",
"type": "progene_text",
"text": [
"ART1"
],
"offsets": [
[
227,
231
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3225 | split_0_train_3225 | [
{
"id": "split_0_train_3225_passage",
"type": "progene_text",
"text": [
"These agonists did not alter the expression of ART3 and ART5 genes ."
],
"offsets": [
[
0,
68
]
]
}
]
| [
{
"id": "split_0_train_5211_entity",
"type": "progene_text",
"text": [
"ART3"
],
"offsets": [
[
47,
51
]
],
"normalized": []
},
{
"id": "split_0_train_5212_entity",
"type": "progene_text",
"text": [
"ART5"
],
"offsets": [
[
56,
60
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3226 | split_0_train_3226 | [
{
"id": "split_0_train_3226_passage",
"type": "progene_text",
"text": [
"Indeed , LTA and flagellin stimulation increased the level of ART1 protein and transcript while ART4 gene was activated after stimulation of cells with LPS , LTA , PAM and PG via TLR2 and TLR4 receptors ."
],
"offsets": [
[
0,
204
]
]
}
]
| [
{
"id": "split_0_train_5213_entity",
"type": "progene_text",
"text": [
"flagellin"
],
"offsets": [
[
17,
26
]
],
"normalized": []
},
{
"id": "split_0_train_5214_entity",
"type": "progene_text",
"text": [
"ART1"
],
"offsets": [
[
62,
66
]
],
"normalized": []
},
{
"id": "split_0_train_5215_entity",
"type": "progene_text",
"text": [
"ART4"
],
"offsets": [
[
96,
100
]
],
"normalized": []
},
{
"id": "split_0_train_5216_entity",
"type": "progene_text",
"text": [
"TLR2"
],
"offsets": [
[
179,
183
]
],
"normalized": []
},
{
"id": "split_0_train_5217_entity",
"type": "progene_text",
"text": [
"TLR4"
],
"offsets": [
[
188,
192
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3227 | split_0_train_3227 | [
{
"id": "split_0_train_3227_passage",
"type": "progene_text",
"text": [
"These results show that human ARTs possess a differential capacity to respond to bacteria cell wall components and might play a crucial role in innate immune response in airways ."
],
"offsets": [
[
0,
179
]
]
}
]
| [
{
"id": "split_0_train_5218_entity",
"type": "progene_text",
"text": [
"ARTs"
],
"offsets": [
[
30,
34
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3228 | split_0_train_3228 | [
{
"id": "split_0_train_3228_passage",
"type": "progene_text",
"text": [
"Microalbuminuria is a negative correlate for cognitive function in older adults with peripheral arterial disease : results from the U.S. National Health and Nutrition Examination Survey 1999 - 2002 ."
],
"offsets": [
[
0,
199
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3229 | split_0_train_3229 | [
{
"id": "split_0_train_3229_passage",
"type": "progene_text",
"text": [
"OBJECTIVES :"
],
"offsets": [
[
0,
12
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3230 | split_0_train_3230 | [
{
"id": "split_0_train_3230_passage",
"type": "progene_text",
"text": [
"Microalbuminuria ( MA ) has been increasingly identified as a marker of cardiovascular risk ."
],
"offsets": [
[
0,
93
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3231 | split_0_train_3231 | [
{
"id": "split_0_train_3231_passage",
"type": "progene_text",
"text": [
"Although poor cognitive function has been implicated as a sequelae of increased cardiovascular burden , little is known about the association between MA and cognitive function ."
],
"offsets": [
[
0,
177
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3232 | split_0_train_3232 | [
{
"id": "split_0_train_3232_passage",
"type": "progene_text",
"text": [
"DESIGN :"
],
"offsets": [
[
0,
8
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3233 | split_0_train_3233 | [
{
"id": "split_0_train_3233_passage",
"type": "progene_text",
"text": [
"Population - based cross - sectional study ."
],
"offsets": [
[
0,
44
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3234 | split_0_train_3234 | [
{
"id": "split_0_train_3234_passage",
"type": "progene_text",
"text": [
"SETTINGS :"
],
"offsets": [
[
0,
10
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3235 | split_0_train_3235 | [
{
"id": "split_0_train_3235_passage",
"type": "progene_text",
"text": [
"National Health and Nutrition Examination Survey 1999 - 2002 in the USA ."
],
"offsets": [
[
0,
73
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3236 | split_0_train_3236 | [
{
"id": "split_0_train_3236_passage",
"type": "progene_text",
"text": [
"SUBJECTS :"
],
"offsets": [
[
0,
10
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3237 | split_0_train_3237 | [
{
"id": "split_0_train_3237_passage",
"type": "progene_text",
"text": [
"2049 noninstitutionalized adults ( > / = 60 years ) with nonmissing values in cognitive test , urinary albumin - to - creatinine ratio ( UACR ) and ankle - brachial blood pressure index ( ABPI ) was analysed ."
],
"offsets": [
[
0,
209
]
]
}
]
| [
{
"id": "split_0_train_5219_entity",
"type": "progene_text",
"text": [
"albumin"
],
"offsets": [
[
103,
110
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3238 | split_0_train_3238 | [
{
"id": "split_0_train_3238_passage",
"type": "progene_text",
"text": [
"Participants with UACR > 300 microg mg(-1) were excluded ."
],
"offsets": [
[
0,
58
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3239 | split_0_train_3239 | [
{
"id": "split_0_train_3239_passage",
"type": "progene_text",
"text": [
"MAIN OUTCOME MEASURES :"
],
"offsets": [
[
0,
23
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3240 | split_0_train_3240 | [
{
"id": "split_0_train_3240_passage",
"type": "progene_text",
"text": [
"The UACR , in the unit of microg mg(-1) , was calculated by dividing the urinary albumin value by the urinary creatinine concentration ."
],
"offsets": [
[
0,
136
]
]
}
]
| [
{
"id": "split_0_train_5220_entity",
"type": "progene_text",
"text": [
"albumin"
],
"offsets": [
[
81,
88
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3241 | split_0_train_3241 | [
{
"id": "split_0_train_3241_passage",
"type": "progene_text",
"text": [
"MA was defined as UACR between 30 and 300 microg mg(-1) ."
],
"offsets": [
[
0,
57
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3242 | split_0_train_3242 | [
{
"id": "split_0_train_3242_passage",
"type": "progene_text",
"text": [
"Cognitive function was measured by a 2-min Digit Symbol Substitution Test ( DSST ) ."
],
"offsets": [
[
0,
84
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3243 | split_0_train_3243 | [
{
"id": "split_0_train_3243_passage",
"type": "progene_text",
"text": [
"Peripheral artery disease ( PAD ) was defined as an ABPI < 0.9 in either leg ."
],
"offsets": [
[
0,
78
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3244 | split_0_train_3244 | [
{
"id": "split_0_train_3244_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3245 | split_0_train_3245 | [
{
"id": "split_0_train_3245_passage",
"type": "progene_text",
"text": [
"Overall speaking , MA was inversely associated with DSST score after controlling for age , sex , race , body mass index and educational level ( regression coefficient = - 2.8 , P = 0.002 ) ."
],
"offsets": [
[
0,
190
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3246 | split_0_train_3246 | [
{
"id": "split_0_train_3246_passage",
"type": "progene_text",
"text": [
"There was an effect modification of PAD on the association between MA and the DSST score ."
],
"offsets": [
[
0,
90
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3247 | split_0_train_3247 | [
{
"id": "split_0_train_3247_passage",
"type": "progene_text",
"text": [
"Amongst participants with PAD , the DSST score for those with MA was lower than those without MA ( beta = - 6.3 , P = 0.003 ) after multivariate adjustment ."
],
"offsets": [
[
0,
157
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3248 | split_0_train_3248 | [
{
"id": "split_0_train_3248_passage",
"type": "progene_text",
"text": [
"Moreover , participants with PAD in the highest quartile of UACR had significantly lower DSST score compared to those in the lowest quartile ( beta = - 8.7 , P = 0.001 ) ."
],
"offsets": [
[
0,
171
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3249 | split_0_train_3249 | [
{
"id": "split_0_train_3249_passage",
"type": "progene_text",
"text": [
"There was no association between MA and cognitive function amongst participants without PAD ."
],
"offsets": [
[
0,
93
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3250 | split_0_train_3250 | [
{
"id": "split_0_train_3250_passage",
"type": "progene_text",
"text": [
"We observed an additive effect of MA and PAD on DSST score ."
],
"offsets": [
[
0,
60
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3251 | split_0_train_3251 | [
{
"id": "split_0_train_3251_passage",
"type": "progene_text",
"text": [
"Participants with both MA and PAD had a lower mean DSST score compared to those without both conditions ( beta = - 6.2 , P = 0.003 ) ."
],
"offsets": [
[
0,
134
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3252 | split_0_train_3252 | [
{
"id": "split_0_train_3252_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3253 | split_0_train_3253 | [
{
"id": "split_0_train_3253_passage",
"type": "progene_text",
"text": [
"The presence of MA or a higher level of urinary albumin excretion was inversely associated with cognitive function in participants with PAD ."
],
"offsets": [
[
0,
141
]
]
}
]
| [
{
"id": "split_0_train_5221_entity",
"type": "progene_text",
"text": [
"albumin"
],
"offsets": [
[
48,
55
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3254 | split_0_train_3254 | [
{
"id": "split_0_train_3254_passage",
"type": "progene_text",
"text": [
"The Bacillus subtilis gene for the development transcription factor sigma K is generated by excision of a dispensable DNA element containing a sporulation recombinase gene ."
],
"offsets": [
[
0,
173
]
]
}
]
| [
{
"id": "split_0_train_5222_entity",
"type": "progene_text",
"text": [
"transcription factor"
],
"offsets": [
[
47,
67
]
],
"normalized": []
},
{
"id": "split_0_train_5223_entity",
"type": "progene_text",
"text": [
"sigma K"
],
"offsets": [
[
68,
75
]
],
"normalized": []
},
{
"id": "split_0_train_5224_entity",
"type": "progene_text",
"text": [
"recombinase"
],
"offsets": [
[
155,
166
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3255 | split_0_train_3255 | [
{
"id": "split_0_train_3255_passage",
"type": "progene_text",
"text": [
"The structural gene ( sigK ) for the mother - cell RNA polymerase sigma - factor sigma K in Bacillus subtilis is a composite of two truncated genes , named spoIVCB and spoIIIC , which are brought together by site - specific recombination during sporulation ."
],
"offsets": [
[
0,
258
]
]
}
]
| [
{
"id": "split_0_train_5225_entity",
"type": "progene_text",
"text": [
"sigK"
],
"offsets": [
[
22,
26
]
],
"normalized": []
},
{
"id": "split_0_train_5226_entity",
"type": "progene_text",
"text": [
"RNA polymerase sigma - factor"
],
"offsets": [
[
51,
80
]
],
"normalized": []
},
{
"id": "split_0_train_5227_entity",
"type": "progene_text",
"text": [
"sigma K"
],
"offsets": [
[
81,
88
]
],
"normalized": []
},
{
"id": "split_0_train_5228_entity",
"type": "progene_text",
"text": [
"spoIVCB"
],
"offsets": [
[
156,
163
]
],
"normalized": []
},
{
"id": "split_0_train_5229_entity",
"type": "progene_text",
"text": [
"spoIIIC"
],
"offsets": [
[
168,
175
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3256 | split_0_train_3256 | [
{
"id": "split_0_train_3256_passage",
"type": "progene_text",
"text": [
"We now show that the recombination event is compartmentalized in that the mother cell , but not the forespore chromosome , undergoes rearrangement ."
],
"offsets": [
[
0,
148
]
]
}
]
| []
| []
| []
| []
|
split_0_train_3257 | split_0_train_3257 | [
{
"id": "split_0_train_3257_passage",
"type": "progene_text",
"text": [
"We also show that spoIIIC ( encoding the carboxy - terminal portion of sigma K ) lies approximately 42 kb downstream of spoIVCB ( encoding the amino - terminal portion ) and that the joining of the truncated coding sequences is a reciprocal recombination event in which intervening DNA is deleted from the chromosome as a circle ."
],
"offsets": [
[
0,
330
]
]
}
]
| [
{
"id": "split_0_train_5230_entity",
"type": "progene_text",
"text": [
"spoIIIC"
],
"offsets": [
[
18,
25
]
],
"normalized": []
},
{
"id": "split_0_train_5231_entity",
"type": "progene_text",
"text": [
"sigma K"
],
"offsets": [
[
71,
78
]
],
"normalized": []
},
{
"id": "split_0_train_5232_entity",
"type": "progene_text",
"text": [
"spoIVCB"
],
"offsets": [
[
120,
127
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3258 | split_0_train_3258 | [
{
"id": "split_0_train_3258_passage",
"type": "progene_text",
"text": [
"The rearrangement is governed by the product of a gene named spoIVCA located in the excised DNA , as demonstrated by the observations (1) that the product of spoIVCA , but not the product of any other stage - IV sporulation gene tested , is required for the rearrangement , and (2) that the presence of a cloned copy of the rearranged sigK gene in the chromosome bypasses the requirement for the spoIVCA gene product in sporulation ."
],
"offsets": [
[
0,
433
]
]
}
]
| [
{
"id": "split_0_train_5233_entity",
"type": "progene_text",
"text": [
"spoIVCA"
],
"offsets": [
[
61,
68
]
],
"normalized": []
},
{
"id": "split_0_train_5234_entity",
"type": "progene_text",
"text": [
"spoIVCA"
],
"offsets": [
[
158,
165
]
],
"normalized": []
},
{
"id": "split_0_train_5235_entity",
"type": "progene_text",
"text": [
"sigK"
],
"offsets": [
[
335,
339
]
],
"normalized": []
},
{
"id": "split_0_train_5236_entity",
"type": "progene_text",
"text": [
"spoIVCA"
],
"offsets": [
[
396,
403
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3259 | split_0_train_3259 | [
{
"id": "split_0_train_3259_passage",
"type": "progene_text",
"text": [
"Because cells engineered to contain an intact copy of sigK sporulate normally , we conclude that the sigK rearrangement is not essential for the control of gene expression during sporulation , and we infer the existence of an additional mechanism for restricting sigma K - directed transcription to the mother - cell chamber of the sporangium ."
],
"offsets": [
[
0,
344
]
]
}
]
| [
{
"id": "split_0_train_5237_entity",
"type": "progene_text",
"text": [
"sigK"
],
"offsets": [
[
54,
58
]
],
"normalized": []
},
{
"id": "split_0_train_5238_entity",
"type": "progene_text",
"text": [
"sigK"
],
"offsets": [
[
101,
105
]
],
"normalized": []
},
{
"id": "split_0_train_5239_entity",
"type": "progene_text",
"text": [
"sigma K"
],
"offsets": [
[
263,
270
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3260 | split_0_train_3260 | [
{
"id": "split_0_train_3260_passage",
"type": "progene_text",
"text": [
"Finally , the construction of a strain deleted for the entire sigK intervening sequence shows that the 42 - kb element contains no genes essential for viability ."
],
"offsets": [
[
0,
162
]
]
}
]
| [
{
"id": "split_0_train_5240_entity",
"type": "progene_text",
"text": [
"sigK"
],
"offsets": [
[
62,
66
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3261 | split_0_train_3261 | [
{
"id": "split_0_train_3261_passage",
"type": "progene_text",
"text": [
"Genetic analysis of RNA polymerase - promoter interaction during sporulation in bacillus subtilis ."
],
"offsets": [
[
0,
99
]
]
}
]
| [
{
"id": "split_0_train_5241_entity",
"type": "progene_text",
"text": [
"RNA polymerase"
],
"offsets": [
[
20,
34
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3262 | split_0_train_3262 | [
{
"id": "split_0_train_3262_passage",
"type": "progene_text",
"text": [
"The discovery of secondary sigma factors in Bacillus subtilis that enable RNA polymerase to transcribe cloned sporulation genes in vitro has led to the proposal that the appearance of new sigma factors during sporulation directs RNA polymerase to the different temporal classes of sporulation genes ."
],
"offsets": [
[
0,
300
]
]
}
]
| [
{
"id": "split_0_train_5242_entity",
"type": "progene_text",
"text": [
"sigma factors"
],
"offsets": [
[
27,
40
]
],
"normalized": []
},
{
"id": "split_0_train_5243_entity",
"type": "progene_text",
"text": [
"RNA polymerase"
],
"offsets": [
[
74,
88
]
],
"normalized": []
},
{
"id": "split_0_train_5244_entity",
"type": "progene_text",
"text": [
"sigma factors"
],
"offsets": [
[
188,
201
]
],
"normalized": []
},
{
"id": "split_0_train_5245_entity",
"type": "progene_text",
"text": [
"RNA polymerase"
],
"offsets": [
[
229,
243
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3263 | split_0_train_3263 | [
{
"id": "split_0_train_3263_passage",
"type": "progene_text",
"text": [
"One sigma factor , which appears 2 h after the initiation of sporulation , is sigma E ( formerly sigma 29 ) ."
],
"offsets": [
[
0,
109
]
]
}
]
| [
{
"id": "split_0_train_5246_entity",
"type": "progene_text",
"text": [
"sigma factor"
],
"offsets": [
[
4,
16
]
],
"normalized": []
},
{
"id": "split_0_train_5247_entity",
"type": "progene_text",
"text": [
"sigma E"
],
"offsets": [
[
78,
85
]
],
"normalized": []
},
{
"id": "split_0_train_5248_entity",
"type": "progene_text",
"text": [
"sigma 29"
],
"offsets": [
[
97,
105
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3264 | split_0_train_3264 | [
{
"id": "split_0_train_3264_passage",
"type": "progene_text",
"text": [
"Mutations that inactivate the structural gene for sigma E prevent transcription from promoter G4 ."
],
"offsets": [
[
0,
98
]
]
}
]
| [
{
"id": "split_0_train_5249_entity",
"type": "progene_text",
"text": [
"sigma E"
],
"offsets": [
[
50,
57
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3265 | split_0_train_3265 | [
{
"id": "split_0_train_3265_passage",
"type": "progene_text",
"text": [
"To determine whether sigma E - RNA polymerase interacts with the G4 promoter in vivo , we examined the effects of six single - base - pair substitutions in the G4 promoter on its utilization in vivo and in vitro by sigma E - RNA polymerase ."
],
"offsets": [
[
0,
241
]
]
}
]
| [
{
"id": "split_0_train_5250_entity",
"type": "progene_text",
"text": [
"sigma E"
],
"offsets": [
[
21,
28
]
],
"normalized": []
},
{
"id": "split_0_train_5251_entity",
"type": "progene_text",
"text": [
"RNA polymerase"
],
"offsets": [
[
31,
45
]
],
"normalized": []
},
{
"id": "split_0_train_5252_entity",
"type": "progene_text",
"text": [
"sigma E"
],
"offsets": [
[
215,
222
]
],
"normalized": []
},
{
"id": "split_0_train_5253_entity",
"type": "progene_text",
"text": [
"RNA polymerase"
],
"offsets": [
[
225,
239
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3266 | split_0_train_3266 | [
{
"id": "split_0_train_3266_passage",
"type": "progene_text",
"text": [
"The mutations in the G4 promoter affected utilization of the promoter in vivo in the same way that they affected its utilization in vitro by purified sigma E - RNA polymerase ; therefore , we conclude that this polymerase interacts directly with the G4 promoter in vivo ."
],
"offsets": [
[
0,
271
]
]
}
]
| [
{
"id": "split_0_train_5254_entity",
"type": "progene_text",
"text": [
"sigma E"
],
"offsets": [
[
150,
157
]
],
"normalized": []
},
{
"id": "split_0_train_5255_entity",
"type": "progene_text",
"text": [
"RNA polymerase"
],
"offsets": [
[
160,
174
]
],
"normalized": []
},
{
"id": "split_0_train_5256_entity",
"type": "progene_text",
"text": [
"polymerase"
],
"offsets": [
[
211,
221
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3267 | split_0_train_3267 | [
{
"id": "split_0_train_3267_passage",
"type": "progene_text",
"text": [
"The effects of these mutations also support the model in which sigma E - RNA polymerase utilizes promoters by interacting with two distinct sets of nucleotides located 10 and 35 base pairs upstream from the start point of transcription ."
],
"offsets": [
[
0,
237
]
]
}
]
| [
{
"id": "split_0_train_5257_entity",
"type": "progene_text",
"text": [
"sigma E"
],
"offsets": [
[
63,
70
]
],
"normalized": []
},
{
"id": "split_0_train_5258_entity",
"type": "progene_text",
"text": [
"RNA polymerase"
],
"offsets": [
[
73,
87
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3268 | split_0_train_3268 | [
{
"id": "split_0_train_3268_passage",
"type": "progene_text",
"text": [
"Expression of the rocDEF operon involved in arginine catabolism in Bacillus subtilis ."
],
"offsets": [
[
0,
86
]
]
}
]
| [
{
"id": "split_0_train_5259_entity",
"type": "progene_text",
"text": [
"rocDEF operon"
],
"offsets": [
[
18,
31
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3269 | split_0_train_3269 | [
{
"id": "split_0_train_3269_passage",
"type": "progene_text",
"text": [
"Three genes called rocD , rocE and rocF were found near the rocR gene in B. subtilis ."
],
"offsets": [
[
0,
86
]
]
}
]
| [
{
"id": "split_0_train_5260_entity",
"type": "progene_text",
"text": [
"rocD"
],
"offsets": [
[
19,
23
]
],
"normalized": []
},
{
"id": "split_0_train_5261_entity",
"type": "progene_text",
"text": [
"rocE"
],
"offsets": [
[
26,
30
]
],
"normalized": []
},
{
"id": "split_0_train_5262_entity",
"type": "progene_text",
"text": [
"rocF"
],
"offsets": [
[
35,
39
]
],
"normalized": []
},
{
"id": "split_0_train_5263_entity",
"type": "progene_text",
"text": [
"rocR"
],
"offsets": [
[
60,
64
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3270 | split_0_train_3270 | [
{
"id": "split_0_train_3270_passage",
"type": "progene_text",
"text": [
"The product of rocD is similar to eukaryotic ornithine aminotransferases ."
],
"offsets": [
[
0,
74
]
]
}
]
| [
{
"id": "split_0_train_5264_entity",
"type": "progene_text",
"text": [
"rocD"
],
"offsets": [
[
15,
19
]
],
"normalized": []
},
{
"id": "split_0_train_5265_entity",
"type": "progene_text",
"text": [
"ornithine aminotransferases"
],
"offsets": [
[
45,
72
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3271 | split_0_train_3271 | [
{
"id": "split_0_train_3271_passage",
"type": "progene_text",
"text": [
"The product of rocE shares similarity with the product of B. subtilis rocC and with the product of E. coli lysP ."
],
"offsets": [
[
0,
113
]
]
}
]
| [
{
"id": "split_0_train_5266_entity",
"type": "progene_text",
"text": [
"rocE"
],
"offsets": [
[
15,
19
]
],
"normalized": []
},
{
"id": "split_0_train_5267_entity",
"type": "progene_text",
"text": [
"rocC"
],
"offsets": [
[
70,
74
]
],
"normalized": []
},
{
"id": "split_0_train_5268_entity",
"type": "progene_text",
"text": [
"lysP"
],
"offsets": [
[
107,
111
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3272 | split_0_train_3272 | [
{
"id": "split_0_train_3272_passage",
"type": "progene_text",
"text": [
"The rocE gene may encode an arginine permease ."
],
"offsets": [
[
0,
47
]
]
}
]
| [
{
"id": "split_0_train_5269_entity",
"type": "progene_text",
"text": [
"rocE"
],
"offsets": [
[
4,
8
]
],
"normalized": []
},
{
"id": "split_0_train_5270_entity",
"type": "progene_text",
"text": [
"permease"
],
"offsets": [
[
37,
45
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3273 | split_0_train_3273 | [
{
"id": "split_0_train_3273_passage",
"type": "progene_text",
"text": [
"The rocF gene encodes a polypeptide similar to several arginases ."
],
"offsets": [
[
0,
66
]
]
}
]
| [
{
"id": "split_0_train_5271_entity",
"type": "progene_text",
"text": [
"rocF"
],
"offsets": [
[
4,
8
]
],
"normalized": []
},
{
"id": "split_0_train_5272_entity",
"type": "progene_text",
"text": [
"arginases"
],
"offsets": [
[
55,
64
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3274 | split_0_train_3274 | [
{
"id": "split_0_train_3274_passage",
"type": "progene_text",
"text": [
"Heterologous expression in E. coli indicated that rocD encodes an ornithine aminotransferase and that rocF encodes an arginase ."
],
"offsets": [
[
0,
128
]
]
}
]
| [
{
"id": "split_0_train_5273_entity",
"type": "progene_text",
"text": [
"rocD"
],
"offsets": [
[
50,
54
]
],
"normalized": []
},
{
"id": "split_0_train_5274_entity",
"type": "progene_text",
"text": [
"ornithine aminotransferase"
],
"offsets": [
[
66,
92
]
],
"normalized": []
},
{
"id": "split_0_train_5275_entity",
"type": "progene_text",
"text": [
"rocF"
],
"offsets": [
[
102,
106
]
],
"normalized": []
},
{
"id": "split_0_train_5276_entity",
"type": "progene_text",
"text": [
"arginase"
],
"offsets": [
[
118,
126
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3275 | split_0_train_3275 | [
{
"id": "split_0_train_3275_passage",
"type": "progene_text",
"text": [
"Arginine utilization was abolished in both rocD and rocF mutants of B. subtilis confirming the role of these genes in arginine catabolism ."
],
"offsets": [
[
0,
139
]
]
}
]
| [
{
"id": "split_0_train_5277_entity",
"type": "progene_text",
"text": [
"rocD"
],
"offsets": [
[
43,
47
]
],
"normalized": []
},
{
"id": "split_0_train_5278_entity",
"type": "progene_text",
"text": [
"rocF"
],
"offsets": [
[
52,
56
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3276 | split_0_train_3276 | [
{
"id": "split_0_train_3276_passage",
"type": "progene_text",
"text": [
"The rocDEF genes form an operon transcribed from a - 12 , - 24 promoter almost identical to the - 12 , - 24 promoter of the rocABC operon ."
],
"offsets": [
[
0,
139
]
]
}
]
| [
{
"id": "split_0_train_5279_entity",
"type": "progene_text",
"text": [
"rocDEF"
],
"offsets": [
[
4,
10
]
],
"normalized": []
},
{
"id": "split_0_train_5280_entity",
"type": "progene_text",
"text": [
"rocABC operon"
],
"offsets": [
[
124,
137
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3277 | split_0_train_3277 | [
{
"id": "split_0_train_3277_passage",
"type": "progene_text",
"text": [
"The expression of the rocDEF operon was induced by the presence of arginine , ornithine or proline in the growth medium and depended on the presence of the sigma factor SigL ."
],
"offsets": [
[
0,
175
]
]
}
]
| [
{
"id": "split_0_train_5281_entity",
"type": "progene_text",
"text": [
"rocDEF operon"
],
"offsets": [
[
22,
35
]
],
"normalized": []
},
{
"id": "split_0_train_5282_entity",
"type": "progene_text",
"text": [
"sigma factor"
],
"offsets": [
[
156,
168
]
],
"normalized": []
},
{
"id": "split_0_train_5283_entity",
"type": "progene_text",
"text": [
"SigL"
],
"offsets": [
[
169,
173
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3278 | split_0_train_3278 | [
{
"id": "split_0_train_3278_passage",
"type": "progene_text",
"text": [
"Transcription of this operon was also abolished in a B. subtilis strain containing a null mutation in the regulatory gene rocR ."
],
"offsets": [
[
0,
128
]
]
}
]
| [
{
"id": "split_0_train_5284_entity",
"type": "progene_text",
"text": [
"rocR"
],
"offsets": [
[
122,
126
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3279 | split_0_train_3279 | [
{
"id": "split_0_train_3279_passage",
"type": "progene_text",
"text": [
"Two tandemly repeated upstream activating sequences very similar to those previously identified in the rocABC system were found centered at positions - 120 and - 70 , respectively , upstream from the transcription start site of rocDEF ."
],
"offsets": [
[
0,
236
]
]
}
]
| [
{
"id": "split_0_train_5285_entity",
"type": "progene_text",
"text": [
"rocABC"
],
"offsets": [
[
103,
109
]
],
"normalized": []
},
{
"id": "split_0_train_5286_entity",
"type": "progene_text",
"text": [
"rocDEF"
],
"offsets": [
[
228,
234
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3280 | split_0_train_3280 | [
{
"id": "split_0_train_3280_passage",
"type": "progene_text",
"text": [
"Deletion analysis showed that at least one upstream activating sequence is involved in the expression of the rocDEF operon ."
],
"offsets": [
[
0,
124
]
]
}
]
| [
{
"id": "split_0_train_5287_entity",
"type": "progene_text",
"text": [
"rocDEF operon"
],
"offsets": [
[
109,
122
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3281 | split_0_train_3281 | [
{
"id": "split_0_train_3281_passage",
"type": "progene_text",
"text": [
"These sequences are probably the target of RocR ."
],
"offsets": [
[
0,
49
]
]
}
]
| [
{
"id": "split_0_train_5288_entity",
"type": "progene_text",
"text": [
"RocR"
],
"offsets": [
[
43,
47
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3282 | split_0_train_3282 | [
{
"id": "split_0_train_3282_passage",
"type": "progene_text",
"text": [
"Analysis of a rocR '-' lacZ fusion strain showed that the expression of rocR is not induced by arginine and is negatively autoregulated ."
],
"offsets": [
[
0,
137
]
]
}
]
| [
{
"id": "split_0_train_5289_entity",
"type": "progene_text",
"text": [
"rocR"
],
"offsets": [
[
14,
18
]
],
"normalized": []
},
{
"id": "split_0_train_5290_entity",
"type": "progene_text",
"text": [
"lacZ"
],
"offsets": [
[
23,
27
]
],
"normalized": []
},
{
"id": "split_0_train_5291_entity",
"type": "progene_text",
"text": [
"rocR"
],
"offsets": [
[
72,
76
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3283 | split_0_train_3283 | [
{
"id": "split_0_train_3283_passage",
"type": "progene_text",
"text": [
"An additional GerE - controlled gene encoding an abundant spore coat protein from Bacillus subtilis ."
],
"offsets": [
[
0,
101
]
]
}
]
| [
{
"id": "split_0_train_5292_entity",
"type": "progene_text",
"text": [
"GerE"
],
"offsets": [
[
14,
18
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3284 | split_0_train_3284 | [
{
"id": "split_0_train_3284_passage",
"type": "progene_text",
"text": [
"We describe the identification and characterization of a gene , herein designated cotG , encoding an abundant coat protein from the spores of Bacillus subtilis ."
],
"offsets": [
[
0,
161
]
]
}
]
| [
{
"id": "split_0_train_5293_entity",
"type": "progene_text",
"text": [
"cotG"
],
"offsets": [
[
82,
86
]
],
"normalized": []
},
{
"id": "split_0_train_5294_entity",
"type": "progene_text",
"text": [
"coat protein"
],
"offsets": [
[
110,
122
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3285 | split_0_train_3285 | [
{
"id": "split_0_train_3285_passage",
"type": "progene_text",
"text": [
"The cotG open reading frame is 195 codons in length and is capable of encoding a polypeptide of 24 kDa that contains nine tandem copies of the 13 - amino - acid long , approximately repeated sequence H / Y-K-K-S-Y-R / C-S / T-H / Y-K-K-S-R-S ."
],
"offsets": [
[
0,
243
]
]
}
]
| [
{
"id": "split_0_train_5295_entity",
"type": "progene_text",
"text": [
"cotG"
],
"offsets": [
[
4,
8
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3286 | split_0_train_3286 | [
{
"id": "split_0_train_3286_passage",
"type": "progene_text",
"text": [
"cotG is located at 300 degrees on the genetic map close to another coat protein gene , cotB ."
],
"offsets": [
[
0,
93
]
]
}
]
| [
{
"id": "split_0_train_5296_entity",
"type": "progene_text",
"text": [
"cotG"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_5297_entity",
"type": "progene_text",
"text": [
"coat protein"
],
"offsets": [
[
67,
79
]
],
"normalized": []
},
{
"id": "split_0_train_5298_entity",
"type": "progene_text",
"text": [
"cotB"
],
"offsets": [
[
87,
91
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3287 | split_0_train_3287 | [
{
"id": "split_0_train_3287_passage",
"type": "progene_text",
"text": [
"The cotG and cotB genes are in divergent orientation and are separated by 1.3 kb ."
],
"offsets": [
[
0,
82
]
]
}
]
| [
{
"id": "split_0_train_5299_entity",
"type": "progene_text",
"text": [
"cotG"
],
"offsets": [
[
4,
8
]
],
"normalized": []
},
{
"id": "split_0_train_5300_entity",
"type": "progene_text",
"text": [
"cotB"
],
"offsets": [
[
13,
17
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3288 | split_0_train_3288 | [
{
"id": "split_0_train_3288_passage",
"type": "progene_text",
"text": [
"Like the promoter for cotB , the cotG promoter is induced at a late stage of sporulation under the control of the RNA polymerase sigma factor sigma K and the DNA - binding protein GerE ."
],
"offsets": [
[
0,
186
]
]
}
]
| [
{
"id": "split_0_train_5301_entity",
"type": "progene_text",
"text": [
"cotB"
],
"offsets": [
[
22,
26
]
],
"normalized": []
},
{
"id": "split_0_train_5302_entity",
"type": "progene_text",
"text": [
"cotG"
],
"offsets": [
[
33,
37
]
],
"normalized": []
},
{
"id": "split_0_train_5303_entity",
"type": "progene_text",
"text": [
"RNA polymerase sigma factor"
],
"offsets": [
[
114,
141
]
],
"normalized": []
},
{
"id": "split_0_train_5304_entity",
"type": "progene_text",
"text": [
"sigma K"
],
"offsets": [
[
142,
149
]
],
"normalized": []
},
{
"id": "split_0_train_5305_entity",
"type": "progene_text",
"text": [
"GerE"
],
"offsets": [
[
180,
184
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3289 | split_0_train_3289 | [
{
"id": "split_0_train_3289_passage",
"type": "progene_text",
"text": [
"The - 10 and - 35 nucleotide sequences of the cotG promoter resemble those of other promoters recognized by sigma K - containing RNA polymerase , and centered 70 bp upstream of the apparent start site is a sequence that matches the consensus binding site for GerE ."
],
"offsets": [
[
0,
265
]
]
}
]
| [
{
"id": "split_0_train_5306_entity",
"type": "progene_text",
"text": [
"cotG"
],
"offsets": [
[
46,
50
]
],
"normalized": []
},
{
"id": "split_0_train_5307_entity",
"type": "progene_text",
"text": [
"sigma K"
],
"offsets": [
[
108,
115
]
],
"normalized": []
},
{
"id": "split_0_train_5308_entity",
"type": "progene_text",
"text": [
"RNA polymerase"
],
"offsets": [
[
129,
143
]
],
"normalized": []
},
{
"id": "split_0_train_5309_entity",
"type": "progene_text",
"text": [
"GerE"
],
"offsets": [
[
259,
263
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3290 | split_0_train_3290 | [
{
"id": "split_0_train_3290_passage",
"type": "progene_text",
"text": [
"Spore coat proteins from a newly constructed cotG null mutant lack not only CotG but also CotB , a finding that suggests that CotG may be a morphogenetic protein that is required for the incorporation of CotB into the coat ."
],
"offsets": [
[
0,
224
]
]
}
]
| [
{
"id": "split_0_train_5310_entity",
"type": "progene_text",
"text": [
"coat proteins"
],
"offsets": [
[
6,
19
]
],
"normalized": []
},
{
"id": "split_0_train_5311_entity",
"type": "progene_text",
"text": [
"cotG"
],
"offsets": [
[
45,
49
]
],
"normalized": []
},
{
"id": "split_0_train_5312_entity",
"type": "progene_text",
"text": [
"CotG"
],
"offsets": [
[
76,
80
]
],
"normalized": []
},
{
"id": "split_0_train_5313_entity",
"type": "progene_text",
"text": [
"CotB"
],
"offsets": [
[
90,
94
]
],
"normalized": []
},
{
"id": "split_0_train_5314_entity",
"type": "progene_text",
"text": [
"CotG"
],
"offsets": [
[
126,
130
]
],
"normalized": []
},
{
"id": "split_0_train_5315_entity",
"type": "progene_text",
"text": [
"CotB"
],
"offsets": [
[
204,
208
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3291 | split_0_train_3291 | [
{
"id": "split_0_train_3291_passage",
"type": "progene_text",
"text": [
"Bacillus subtilis spoVE gene is transcribed by sigma E - associated RNA polymerase ."
],
"offsets": [
[
0,
84
]
]
}
]
| [
{
"id": "split_0_train_5316_entity",
"type": "progene_text",
"text": [
"spoVE"
],
"offsets": [
[
18,
23
]
],
"normalized": []
},
{
"id": "split_0_train_5317_entity",
"type": "progene_text",
"text": [
"sigma E"
],
"offsets": [
[
47,
54
]
],
"normalized": []
},
{
"id": "split_0_train_5318_entity",
"type": "progene_text",
"text": [
"RNA polymerase"
],
"offsets": [
[
68,
82
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3292 | split_0_train_3292 | [
{
"id": "split_0_train_3292_passage",
"type": "progene_text",
"text": [
"Expression of the Bacillus subtilis sporulation gene spoVE was examined by runoff transcription assay with an RNA polymerase preparation obtained from vegetative and sporulating cells ."
],
"offsets": [
[
0,
185
]
]
}
]
| [
{
"id": "split_0_train_5319_entity",
"type": "progene_text",
"text": [
"spoVE"
],
"offsets": [
[
53,
58
]
],
"normalized": []
},
{
"id": "split_0_train_5320_entity",
"type": "progene_text",
"text": [
"RNA polymerase"
],
"offsets": [
[
110,
124
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3293 | split_0_train_3293 | [
{
"id": "split_0_train_3293_passage",
"type": "progene_text",
"text": [
"Transcripts from tandem promoters ( P1 and P2 promoters ) located just upstream of the spoVE structure gene were detected ."
],
"offsets": [
[
0,
123
]
]
}
]
| [
{
"id": "split_0_train_5321_entity",
"type": "progene_text",
"text": [
"spoVE"
],
"offsets": [
[
87,
92
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3294 | split_0_train_3294 | [
{
"id": "split_0_train_3294_passage",
"type": "progene_text",
"text": [
"The transcription of spoVE initiated within an hour after the onset of sporulation and coincided with the presence of RNA polymerase associated with a 33 - kDa protein ."
],
"offsets": [
[
0,
169
]
]
}
]
| [
{
"id": "split_0_train_5322_entity",
"type": "progene_text",
"text": [
"spoVE"
],
"offsets": [
[
21,
26
]
],
"normalized": []
},
{
"id": "split_0_train_5323_entity",
"type": "progene_text",
"text": [
"RNA polymerase"
],
"offsets": [
[
118,
132
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3295 | split_0_train_3295 | [
{
"id": "split_0_train_3295_passage",
"type": "progene_text",
"text": [
"Amino acid sequence analysis of the 33 - kDa protein revealed that it is a sigma factor , sigma E ."
],
"offsets": [
[
0,
99
]
]
}
]
| [
{
"id": "split_0_train_5324_entity",
"type": "progene_text",
"text": [
"sigma factor"
],
"offsets": [
[
75,
87
]
],
"normalized": []
},
{
"id": "split_0_train_5325_entity",
"type": "progene_text",
"text": [
"sigma E"
],
"offsets": [
[
90,
97
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3296 | split_0_train_3296 | [
{
"id": "split_0_train_3296_passage",
"type": "progene_text",
"text": [
"Reconstitution analysis of sigma E purified from the sporulating cell extracts and vegetative core RNA polymerase showed that sigma E recognizes the P2 promoter ."
],
"offsets": [
[
0,
162
]
]
}
]
| [
{
"id": "split_0_train_5326_entity",
"type": "progene_text",
"text": [
"sigma E"
],
"offsets": [
[
27,
34
]
],
"normalized": []
},
{
"id": "split_0_train_5327_entity",
"type": "progene_text",
"text": [
"RNA polymerase"
],
"offsets": [
[
99,
113
]
],
"normalized": []
},
{
"id": "split_0_train_5328_entity",
"type": "progene_text",
"text": [
"sigma E"
],
"offsets": [
[
126,
133
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3297 | split_0_train_3297 | [
{
"id": "split_0_train_3297_passage",
"type": "progene_text",
"text": [
"SpoVE protein could not be synthesized in the transcription - translation coupled system prepared from vegetative cells ( M. Okamoto , S. Fukui , and Y. Kobayashi , Agric. Biol. Chem. 49 : 1077 - 1082 , 1985 ) ."
],
"offsets": [
[
0,
211
]
]
}
]
| [
{
"id": "split_0_train_5329_entity",
"type": "progene_text",
"text": [
"SpoVE"
],
"offsets": [
[
0,
5
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3298 | split_0_train_3298 | [
{
"id": "split_0_train_3298_passage",
"type": "progene_text",
"text": [
"However , addition of sigma E - associated RNA polymerase to the coupled system restored SpoVE protein synthesis ."
],
"offsets": [
[
0,
114
]
]
}
]
| [
{
"id": "split_0_train_5330_entity",
"type": "progene_text",
"text": [
"sigma E"
],
"offsets": [
[
22,
29
]
],
"normalized": []
},
{
"id": "split_0_train_5331_entity",
"type": "progene_text",
"text": [
"RNA polymerase"
],
"offsets": [
[
43,
57
]
],
"normalized": []
},
{
"id": "split_0_train_5332_entity",
"type": "progene_text",
"text": [
"SpoVE"
],
"offsets": [
[
89,
94
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_3299 | split_0_train_3299 | [
{
"id": "split_0_train_3299_passage",
"type": "progene_text",
"text": [
"These results indicate that spoVE expression in sporulating cells is controlled essentially by sigma E - associated RNA polymerase ."
],
"offsets": [
[
0,
132
]
]
}
]
| [
{
"id": "split_0_train_5333_entity",
"type": "progene_text",
"text": [
"spoVE"
],
"offsets": [
[
28,
33
]
],
"normalized": []
},
{
"id": "split_0_train_5334_entity",
"type": "progene_text",
"text": [
"sigma E"
],
"offsets": [
[
95,
102
]
],
"normalized": []
},
{
"id": "split_0_train_5335_entity",
"type": "progene_text",
"text": [
"RNA polymerase"
],
"offsets": [
[
116,
130
]
],
"normalized": []
}
]
| []
| []
| []
|
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