id
stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
split_0_train_500 | split_0_train_500 | [
{
"id": "split_0_train_500_passage",
"type": "progene_text",
"text": [
"ELISA also demonstrated the presence of anti - trypanosome antibodies in many of the suspects tested ( 63 % , 38 % , 24 % and 66.9 % of those in Cameroon , C�´te d' Ivoire , Tanzania , and Malawi , respectively ) ."
],
"offsets": [
[
0,
216
]
]
}
]
| []
| []
| []
| []
|
split_0_train_501 | split_0_train_501 | [
{
"id": "split_0_train_501_passage",
"type": "progene_text",
"text": [
"A follow - up of 164 patients treated with melarsoprol revealed that , by 9 months post - treatment , 113 ( 69.0 % ) had no detectable trypanosome antigens in their peripheral blood ."
],
"offsets": [
[
0,
183
]
]
}
]
| []
| []
| []
| []
|
split_0_train_502 | split_0_train_502 | [
{
"id": "split_0_train_502_passage",
"type": "progene_text",
"text": [
"The test could therefore be used for evaluating chemotherapeutic cure , as well as for diagnosis ."
],
"offsets": [
[
0,
98
]
]
}
]
| []
| []
| []
| []
|
split_0_train_503 | split_0_train_503 | [
{
"id": "split_0_train_503_passage",
"type": "progene_text",
"text": [
"Effect of inserting paramyxovirus simian virus 5 gene junctions at the HN / L gene junction : analysis of accumulation of mRNAs transcribed from rescued viable viruses ."
],
"offsets": [
[
0,
169
]
]
}
]
| [
{
"id": "split_0_train_662_entity",
"type": "progene_text",
"text": [
"HN"
],
"offsets": [
[
71,
73
]
],
"normalized": []
},
{
"id": "split_0_train_663_entity",
"type": "progene_text",
"text": [
"L"
],
"offsets": [
[
76,
77
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_504 | split_0_train_504 | [
{
"id": "split_0_train_504_passage",
"type": "progene_text",
"text": [
"Simian parainfluenza virus 5 ( SV5 ) is a prototype of the Paramyxoviridae family of nonsegmented negative - sense RNA viruses ."
],
"offsets": [
[
0,
128
]
]
}
]
| []
| []
| []
| []
|
split_0_train_505 | split_0_train_505 | [
{
"id": "split_0_train_505_passage",
"type": "progene_text",
"text": [
"The single - stranded RNA genomes of these viruses contain a series of tandemly linked genes separated by intergenic ( IG ) sequences flanked by gene - end ( GE ) and gene - start ( GS ) sequences ."
],
"offsets": [
[
0,
198
]
]
}
]
| []
| []
| []
| []
|
split_0_train_506 | split_0_train_506 | [
{
"id": "split_0_train_506_passage",
"type": "progene_text",
"text": [
"The viral RNA polymerase ( vRNAP ) complex is thought to enter the genome at its 3' end , and synthesis of mRNAs is thought to occur by a stop - start mechanism in a sequential and polar manner , with transcriptional attenuation occurring primarily at the intergenic regions ."
],
"offsets": [
[
0,
276
]
]
}
]
| [
{
"id": "split_0_train_664_entity",
"type": "progene_text",
"text": [
"RNA polymerase"
],
"offsets": [
[
10,
24
]
],
"normalized": []
},
{
"id": "split_0_train_665_entity",
"type": "progene_text",
"text": [
"vRNAP"
],
"offsets": [
[
27,
32
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_507 | split_0_train_507 | [
{
"id": "split_0_train_507_passage",
"type": "progene_text",
"text": [
"As a result , multiple nonoverlapping mRNA species are generated for each single entry of the vRNAP ."
],
"offsets": [
[
0,
101
]
]
}
]
| [
{
"id": "split_0_train_666_entity",
"type": "progene_text",
"text": [
"vRNAP"
],
"offsets": [
[
94,
99
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_508 | split_0_train_508 | [
{
"id": "split_0_train_508_passage",
"type": "progene_text",
"text": [
"To investigate the functions of GE , IG , and GS sequences in transcription , we constructed plasmids containing cDNAs of the full - length SV5 genome in which the gene junction sequences ( GE , IG , and GS sequences ) located between the hemagglutinin - neuraminidase ( HN ) and the polymerase ( L ) genes were replaced with the counterpart sequences from other gene junctions ."
],
"offsets": [
[
0,
379
]
]
}
]
| [
{
"id": "split_0_train_667_entity",
"type": "progene_text",
"text": [
"hemagglutinin - neuraminidase"
],
"offsets": [
[
239,
268
]
],
"normalized": []
},
{
"id": "split_0_train_668_entity",
"type": "progene_text",
"text": [
"HN"
],
"offsets": [
[
271,
273
]
],
"normalized": []
},
{
"id": "split_0_train_669_entity",
"type": "progene_text",
"text": [
"polymerase ( L )"
],
"offsets": [
[
284,
300
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_509 | split_0_train_509 | [
{
"id": "split_0_train_509_passage",
"type": "progene_text",
"text": [
"By using reverse genetics , we recovered viable viruses from each cDNA construct , although their growth characteristics varied ."
],
"offsets": [
[
0,
129
]
]
}
]
| []
| []
| []
| []
|
split_0_train_510 | split_0_train_510 | [
{
"id": "split_0_train_510_passage",
"type": "progene_text",
"text": [
"Analysis of the HN and L mRNAs by quantitative RNase protection assay indicated that the ratios of HN to L mRNAs varied over a fourfold range ."
],
"offsets": [
[
0,
143
]
]
}
]
| [
{
"id": "split_0_train_670_entity",
"type": "progene_text",
"text": [
"HN"
],
"offsets": [
[
16,
18
]
],
"normalized": []
},
{
"id": "split_0_train_671_entity",
"type": "progene_text",
"text": [
"L"
],
"offsets": [
[
23,
24
]
],
"normalized": []
},
{
"id": "split_0_train_672_entity",
"type": "progene_text",
"text": [
"RNase"
],
"offsets": [
[
47,
52
]
],
"normalized": []
},
{
"id": "split_0_train_673_entity",
"type": "progene_text",
"text": [
"HN"
],
"offsets": [
[
99,
101
]
],
"normalized": []
},
{
"id": "split_0_train_674_entity",
"type": "progene_text",
"text": [
"L"
],
"offsets": [
[
105,
106
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_511 | split_0_train_511 | [
{
"id": "split_0_train_511_passage",
"type": "progene_text",
"text": [
"The alteration of the gene junction sequences also permitted examination of the hypothesized requirement for hexamer nucleotide position of the GS sites ."
],
"offsets": [
[
0,
154
]
]
}
]
| []
| []
| []
| []
|
split_0_train_512 | split_0_train_512 | [
{
"id": "split_0_train_512_passage",
"type": "progene_text",
"text": [
"The recovery of infectious viruses with transcription initiation sites that occurred at nucleotide positions 1 , 2 , 3 , 5 , and 6 of the hexamer suggest that the requirement is nonstringent ."
],
"offsets": [
[
0,
192
]
]
}
]
| []
| []
| []
| []
|
split_0_train_513 | split_0_train_513 | [
{
"id": "split_0_train_513_passage",
"type": "progene_text",
"text": [
"Characterization of three splice variants and genomic organization of the mouse BMAL1 gene ."
],
"offsets": [
[
0,
92
]
]
}
]
| [
{
"id": "split_0_train_675_entity",
"type": "progene_text",
"text": [
"BMAL1"
],
"offsets": [
[
80,
85
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_514 | split_0_train_514 | [
{
"id": "split_0_train_514_passage",
"type": "progene_text",
"text": [
"The BMAL1 gene encodes a member of the basic helix - loop - helix / PER-ARNT-SIM ( bHLH / PAS ) family of transcription factors ."
],
"offsets": [
[
0,
129
]
]
}
]
| [
{
"id": "split_0_train_676_entity",
"type": "progene_text",
"text": [
"BMAL1"
],
"offsets": [
[
4,
9
]
],
"normalized": []
},
{
"id": "split_0_train_677_entity",
"type": "progene_text",
"text": [
"transcription factors"
],
"offsets": [
[
106,
127
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_515 | split_0_train_515 | [
{
"id": "split_0_train_515_passage",
"type": "progene_text",
"text": [
"It is a key regulator of circadian rhythms ."
],
"offsets": [
[
0,
44
]
]
}
]
| []
| []
| []
| []
|
split_0_train_516 | split_0_train_516 | [
{
"id": "split_0_train_516_passage",
"type": "progene_text",
"text": [
"Using sequence information from human BMAL1 ( hBMAL1 ) cDNAs previously reported by our laboratory , we have isolated and characterized cDNAs encoding three splice variants of the mouse BMAL1 ( mBMAL1 ) gene ."
],
"offsets": [
[
0,
209
]
]
}
]
| [
{
"id": "split_0_train_678_entity",
"type": "progene_text",
"text": [
"BMAL1"
],
"offsets": [
[
38,
43
]
],
"normalized": []
},
{
"id": "split_0_train_679_entity",
"type": "progene_text",
"text": [
"hBMAL1"
],
"offsets": [
[
46,
52
]
],
"normalized": []
},
{
"id": "split_0_train_680_entity",
"type": "progene_text",
"text": [
"BMAL1"
],
"offsets": [
[
186,
191
]
],
"normalized": []
},
{
"id": "split_0_train_681_entity",
"type": "progene_text",
"text": [
"mBMAL1"
],
"offsets": [
[
194,
200
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_517 | split_0_train_517 | [
{
"id": "split_0_train_517_passage",
"type": "progene_text",
"text": [
"Of the three splice variants , mBMAL1b extends for 1878 bp in the coding sequence , which is 91 % identical to that of hBMAL1b ; its deduced amino acid sequence is 626 residues long and is 98 % identical to that of hBMAL1b , and sequence identities in the bHLH , PAS-A , and PAS-B regions are 98 , 100 , and 100 % , respectively ."
],
"offsets": [
[
0,
330
]
]
}
]
| [
{
"id": "split_0_train_682_entity",
"type": "progene_text",
"text": [
"mBMAL1b"
],
"offsets": [
[
31,
38
]
],
"normalized": []
},
{
"id": "split_0_train_683_entity",
"type": "progene_text",
"text": [
"hBMAL1b"
],
"offsets": [
[
119,
126
]
],
"normalized": []
},
{
"id": "split_0_train_684_entity",
"type": "progene_text",
"text": [
"hBMAL1b"
],
"offsets": [
[
215,
222
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_518 | split_0_train_518 | [
{
"id": "split_0_train_518_passage",
"type": "progene_text",
"text": [
"mBMAL1b ' arises from alternative usage of exon 2 , which results in a 7 - amino - acid insertion and alternative splice acceptor usage at the intron 9 / exon 10 splice junction , which causes an alanine residue deletion ."
],
"offsets": [
[
0,
222
]
]
}
]
| [
{
"id": "split_0_train_685_entity",
"type": "progene_text",
"text": [
"mBMAL1b '"
],
"offsets": [
[
0,
9
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_519 | split_0_train_519 | [
{
"id": "split_0_train_519_passage",
"type": "progene_text",
"text": [
"mBMAL1b ' encodes 632 amino acids and contains the bHLH / PAS domains ."
],
"offsets": [
[
0,
71
]
]
}
]
| [
{
"id": "split_0_train_686_entity",
"type": "progene_text",
"text": [
"mBMAL1b '"
],
"offsets": [
[
0,
9
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_520 | split_0_train_520 | [
{
"id": "split_0_train_520_passage",
"type": "progene_text",
"text": [
"mBMAL1g ' is generated by alternative splice acceptor usage at the intron 6 / exon 7 splice junction , which results in a 28 - bp deletion adjacent to the 5' end of the PAS domain ."
],
"offsets": [
[
0,
181
]
]
}
]
| [
{
"id": "split_0_train_687_entity",
"type": "progene_text",
"text": [
"mBMAL1g '"
],
"offsets": [
[
0,
9
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_521 | split_0_train_521 | [
{
"id": "split_0_train_521_passage",
"type": "progene_text",
"text": [
"Since the 28 - bp deletion shifts the reading frame , mBMAL1g ' is predicted to encode a product of only 222 amino acids that lacks the PAS domain ."
],
"offsets": [
[
0,
148
]
]
}
]
| [
{
"id": "split_0_train_688_entity",
"type": "progene_text",
"text": [
"mBMAL1g '"
],
"offsets": [
[
54,
63
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_522 | split_0_train_522 | [
{
"id": "split_0_train_522_passage",
"type": "progene_text",
"text": [
"The tissue distributions of the three splice variants showed some variation ."
],
"offsets": [
[
0,
77
]
]
}
]
| []
| []
| []
| []
|
split_0_train_523 | split_0_train_523 | [
{
"id": "split_0_train_523_passage",
"type": "progene_text",
"text": [
"The variations in the tissue distributions and predicted amino acid sequences suggest that the three splice variants may have different functions ."
],
"offsets": [
[
0,
147
]
]
}
]
| []
| []
| []
| []
|
split_0_train_524 | split_0_train_524 | [
{
"id": "split_0_train_524_passage",
"type": "progene_text",
"text": [
"Direct sequencing of the genomic mBMAL1 clones indicated that the coding sequence of mBMAL1 spans 32 kb and includes 17 exons ."
],
"offsets": [
[
0,
127
]
]
}
]
| [
{
"id": "split_0_train_689_entity",
"type": "progene_text",
"text": [
"mBMAL1"
],
"offsets": [
[
33,
39
]
],
"normalized": []
},
{
"id": "split_0_train_690_entity",
"type": "progene_text",
"text": [
"mBMAL1"
],
"offsets": [
[
85,
91
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_525 | split_0_train_525 | [
{
"id": "split_0_train_525_passage",
"type": "progene_text",
"text": [
"An unusual exon / intron donor sequence was found in intron 14 , which begins with GC at the 5' end ."
],
"offsets": [
[
0,
101
]
]
}
]
| []
| []
| []
| []
|
split_0_train_526 | split_0_train_526 | [
{
"id": "split_0_train_526_passage",
"type": "progene_text",
"text": [
"Comparison with the bHLH / PAS family genes revealed that the intron / exon splice pattern of mBMAL1 most closely matches that of the mAhr , which suggests that BMAL1 and Ahr belong to the same subclass and may be derived from a common primordial gene ."
],
"offsets": [
[
0,
253
]
]
}
]
| [
{
"id": "split_0_train_691_entity",
"type": "progene_text",
"text": [
"mBMAL1"
],
"offsets": [
[
94,
100
]
],
"normalized": []
},
{
"id": "split_0_train_692_entity",
"type": "progene_text",
"text": [
"mAhr"
],
"offsets": [
[
134,
138
]
],
"normalized": []
},
{
"id": "split_0_train_693_entity",
"type": "progene_text",
"text": [
"BMAL1"
],
"offsets": [
[
161,
166
]
],
"normalized": []
},
{
"id": "split_0_train_694_entity",
"type": "progene_text",
"text": [
"Ahr"
],
"offsets": [
[
171,
174
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_527 | split_0_train_527 | [
{
"id": "split_0_train_527_passage",
"type": "progene_text",
"text": [
"Phosphorylation , dephosphorylation and DNA - binding of the Bradyrhizobium japonicum RegSR two - component regulatory proteins ."
],
"offsets": [
[
0,
129
]
]
}
]
| [
{
"id": "split_0_train_695_entity",
"type": "progene_text",
"text": [
"RegSR"
],
"offsets": [
[
86,
91
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_528 | split_0_train_528 | [
{
"id": "split_0_train_528_passage",
"type": "progene_text",
"text": [
"Under low oxygen conditions , induction of many genes required for nitrogen fixation in Bradyrhizobium japonicum depends on the redox - responsive transcriptional activator NifA which is encoded in the fixR - nifA operon ."
],
"offsets": [
[
0,
222
]
]
}
]
| [
{
"id": "split_0_train_696_entity",
"type": "progene_text",
"text": [
"NifA"
],
"offsets": [
[
173,
177
]
],
"normalized": []
},
{
"id": "split_0_train_697_entity",
"type": "progene_text",
"text": [
"fixR - nifA operon"
],
"offsets": [
[
202,
220
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_529 | split_0_train_529 | [
{
"id": "split_0_train_529_passage",
"type": "progene_text",
"text": [
"Basal expression of this operon depends on the response regulator RegR and a DNA element located around position - 68 in the fixR - nifA promoter region ."
],
"offsets": [
[
0,
154
]
]
}
]
| [
{
"id": "split_0_train_698_entity",
"type": "progene_text",
"text": [
"RegR"
],
"offsets": [
[
66,
70
]
],
"normalized": []
},
{
"id": "split_0_train_699_entity",
"type": "progene_text",
"text": [
"fixR"
],
"offsets": [
[
125,
129
]
],
"normalized": []
},
{
"id": "split_0_train_700_entity",
"type": "progene_text",
"text": [
"nifA"
],
"offsets": [
[
132,
136
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_530 | split_0_train_530 | [
{
"id": "split_0_train_530_passage",
"type": "progene_text",
"text": [
"To investigate the functional properties of RegR and the interaction with its putative cognate kinase , RegS , we overproduced and affinity - purified RegR and a truncated soluble variant of RegS ( RegS ( C ) ) , both as N-terminally His ( 6 ) - tagged proteins ."
],
"offsets": [
[
0,
263
]
]
}
]
| [
{
"id": "split_0_train_701_entity",
"type": "progene_text",
"text": [
"RegR"
],
"offsets": [
[
44,
48
]
],
"normalized": []
},
{
"id": "split_0_train_702_entity",
"type": "progene_text",
"text": [
"kinase"
],
"offsets": [
[
95,
101
]
],
"normalized": []
},
{
"id": "split_0_train_703_entity",
"type": "progene_text",
"text": [
"RegS"
],
"offsets": [
[
104,
108
]
],
"normalized": []
},
{
"id": "split_0_train_704_entity",
"type": "progene_text",
"text": [
"RegR"
],
"offsets": [
[
151,
155
]
],
"normalized": []
},
{
"id": "split_0_train_705_entity",
"type": "progene_text",
"text": [
"RegS"
],
"offsets": [
[
191,
195
]
],
"normalized": []
},
{
"id": "split_0_train_706_entity",
"type": "progene_text",
"text": [
"RegS"
],
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[
198,
202
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],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_531 | split_0_train_531 | [
{
"id": "split_0_train_531_passage",
"type": "progene_text",
"text": [
"RegS (C) autophosphorylated when incubated with [gamma-(32)P]ATP , and it catalyzed the transfer of the phosphoryl label to RegR ."
],
"offsets": [
[
0,
130
]
]
}
]
| [
{
"id": "split_0_train_707_entity",
"type": "progene_text",
"text": [
"RegS"
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0,
4
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{
"id": "split_0_train_708_entity",
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"text": [
"RegR"
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[
124,
128
]
],
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}
]
| []
| []
| []
|
split_0_train_532 | split_0_train_532 | [
{
"id": "split_0_train_532_passage",
"type": "progene_text",
"text": [
"The phosphorylated form of RegS (C) exhibited phosphatase activity on RegR - phosphate ."
],
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[
0,
88
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]
}
]
| [
{
"id": "split_0_train_709_entity",
"type": "progene_text",
"text": [
"RegS"
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27,
31
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},
{
"id": "split_0_train_710_entity",
"type": "progene_text",
"text": [
"phosphatase"
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46,
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},
{
"id": "split_0_train_711_entity",
"type": "progene_text",
"text": [
"RegR"
],
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[
70,
74
]
],
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}
]
| []
| []
| []
|
split_0_train_533 | split_0_train_533 | [
{
"id": "split_0_train_533_passage",
"type": "progene_text",
"text": [
"Chemical stability tests and site - specific mutagenesis identified amino acids H219 and D63 of RegS and RegR , respectively , as the phosphorylated residues ."
],
"offsets": [
[
0,
159
]
]
}
]
| [
{
"id": "split_0_train_712_entity",
"type": "progene_text",
"text": [
"RegS"
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[
96,
100
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},
{
"id": "split_0_train_713_entity",
"type": "progene_text",
"text": [
"RegR"
],
"offsets": [
[
105,
109
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_534 | split_0_train_534 | [
{
"id": "split_0_train_534_passage",
"type": "progene_text",
"text": [
"Competition experiments with isolated domains demonstrated that the N - terminal but not the C - terminal domain of RegR interacts with RegS ( C ) ."
],
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[
0,
148
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]
}
]
| [
{
"id": "split_0_train_714_entity",
"type": "progene_text",
"text": [
"RegR"
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116,
120
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{
"id": "split_0_train_715_entity",
"type": "progene_text",
"text": [
"RegS"
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"offsets": [
[
136,
140
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_535 | split_0_train_535 | [
{
"id": "split_0_train_535_passage",
"type": "progene_text",
"text": [
"Band - shift experiments revealed that phosphorylated RegR had at least eightfold enhanced DNA - binding activity compared with dephosphorylated RegR or the mutant protein RegR - D63 , which cannot be phosphorylated ."
],
"offsets": [
[
0,
217
]
]
}
]
| [
{
"id": "split_0_train_716_entity",
"type": "progene_text",
"text": [
"RegR"
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[
54,
58
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{
"id": "split_0_train_717_entity",
"type": "progene_text",
"text": [
"RegR"
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145,
149
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{
"id": "split_0_train_718_entity",
"type": "progene_text",
"text": [
"RegR"
],
"offsets": [
[
172,
176
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_536 | split_0_train_536 | [
{
"id": "split_0_train_536_passage",
"type": "progene_text",
"text": [
"In conclusion , the RegSR proteins of B. japonicum exhibit functional properties in vitro that are typical of two - component regulatory systems ."
],
"offsets": [
[
0,
146
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]
}
]
| [
{
"id": "split_0_train_719_entity",
"type": "progene_text",
"text": [
"RegSR"
],
"offsets": [
[
20,
25
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_537 | split_0_train_537 | [
{
"id": "split_0_train_537_passage",
"type": "progene_text",
"text": [
"Bcl-2 and Bcl-X(L) block thapsigargin - induced nitric oxide generation , c-Jun NH(2) - terminal kinase activity , and apoptosis ."
],
"offsets": [
[
0,
130
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]
}
]
| [
{
"id": "split_0_train_720_entity",
"type": "progene_text",
"text": [
"Bcl-2"
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"offsets": [
[
0,
5
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},
{
"id": "split_0_train_721_entity",
"type": "progene_text",
"text": [
"Bcl-X(L)"
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[
10,
18
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},
{
"id": "split_0_train_722_entity",
"type": "progene_text",
"text": [
"c-Jun NH(2) - terminal kinase"
],
"offsets": [
[
74,
103
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_538 | split_0_train_538 | [
{
"id": "split_0_train_538_passage",
"type": "progene_text",
"text": [
"The proteins Bcl-2 and Bcl-X(L) prevent apoptosis , but their mechanism of action is unclear ."
],
"offsets": [
[
0,
94
]
]
}
]
| [
{
"id": "split_0_train_723_entity",
"type": "progene_text",
"text": [
"Bcl-2"
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"offsets": [
[
13,
18
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],
"normalized": []
},
{
"id": "split_0_train_724_entity",
"type": "progene_text",
"text": [
"Bcl-X(L)"
],
"offsets": [
[
23,
31
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_539 | split_0_train_539 | [
{
"id": "split_0_train_539_passage",
"type": "progene_text",
"text": [
"We examined the role of Bcl-2 and Bcl-X(L) in the regulation of cytosolic Ca(2+) , nitric oxide production ( NO ) , c-Jun NH(2)-terminal kinase ( JNK ) activation , and apoptosis in Jurkat T cells ."
],
"offsets": [
[
0,
198
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]
}
]
| [
{
"id": "split_0_train_725_entity",
"type": "progene_text",
"text": [
"Bcl-2"
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[
24,
29
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],
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},
{
"id": "split_0_train_726_entity",
"type": "progene_text",
"text": [
"Bcl-X(L)"
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"offsets": [
[
34,
42
]
],
"normalized": []
},
{
"id": "split_0_train_727_entity",
"type": "progene_text",
"text": [
"c-Jun NH(2)-terminal kinase"
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[
116,
143
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"normalized": []
},
{
"id": "split_0_train_728_entity",
"type": "progene_text",
"text": [
"JNK"
],
"offsets": [
[
146,
149
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_540 | split_0_train_540 | [
{
"id": "split_0_train_540_passage",
"type": "progene_text",
"text": [
"Thapsigargin ( TG ) , an inhibitor of the endoplasmic reticulum - associated Ca(2+) ATPase , was used to disrupt Ca(2+) homeostasis ."
],
"offsets": [
[
0,
133
]
]
}
]
| [
{
"id": "split_0_train_729_entity",
"type": "progene_text",
"text": [
"endoplasmic reticulum - associated Ca(2+) ATPase"
],
"offsets": [
[
42,
90
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_541 | split_0_train_541 | [
{
"id": "split_0_train_541_passage",
"type": "progene_text",
"text": [
"TG acutely elevated intracellular free Ca(2+) and mitochondrial Ca(2+) levels and induced NO production and apoptosis in Jurkat cells transfected with vector ( JT / Neo ) ."
],
"offsets": [
[
0,
172
]
]
}
]
| []
| []
| []
| []
|
split_0_train_542 | split_0_train_542 | [
{
"id": "split_0_train_542_passage",
"type": "progene_text",
"text": [
"Buffering of this Ca(2+) response with 1 , 2-bis(o-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetra(acetoxymethyl) ester ( BAPTA-AM ) or inhibiting NO synthase activity with N(G)-nitro-L-arginine methyl ester hydrochloride ( L-NAME ) blocked TG - induced NO production and apoptosis in JT / Neo cells ."
],
"offsets": [
[
0,
306
]
]
}
]
| [
{
"id": "split_0_train_730_entity",
"type": "progene_text",
"text": [
"NO synthase"
],
"offsets": [
[
152,
163
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_543 | split_0_train_543 | [
{
"id": "split_0_train_543_passage",
"type": "progene_text",
"text": [
"By contrast , while TG produced comparable early changes in the Ca(2+) level ( i.e. , within 3 h ) in Jurkat cells overexpressing Bcl-2 and Bcl-X ( L ) ( JT / Bcl-2 or JT / Bcl-X(L) ) , NO production , late ( 36-h) Ca(2+) accumulation , and apoptosis were dramatically reduced compared to those in JT / Neo cells ."
],
"offsets": [
[
0,
314
]
]
}
]
| [
{
"id": "split_0_train_731_entity",
"type": "progene_text",
"text": [
"Bcl-2"
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"offsets": [
[
130,
135
]
],
"normalized": []
},
{
"id": "split_0_train_732_entity",
"type": "progene_text",
"text": [
"Bcl-X ( L )"
],
"offsets": [
[
140,
151
]
],
"normalized": []
},
{
"id": "split_0_train_733_entity",
"type": "progene_text",
"text": [
"Bcl-2"
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"offsets": [
[
159,
164
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],
"normalized": []
},
{
"id": "split_0_train_734_entity",
"type": "progene_text",
"text": [
"Bcl-X(L)"
],
"offsets": [
[
173,
181
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_544 | split_0_train_544 | [
{
"id": "split_0_train_544_passage",
"type": "progene_text",
"text": [
"Exposure of JT / Bcl-2 and JT / Bcl-X(L) cells to the NO donor , S-nitroso-N-acetylpenacillamine ( SNAP ) resulted in apoptosis comparable to that seen in JT / Neo cells ."
],
"offsets": [
[
0,
171
]
]
}
]
| [
{
"id": "split_0_train_735_entity",
"type": "progene_text",
"text": [
"Bcl-2"
],
"offsets": [
[
17,
22
]
],
"normalized": []
},
{
"id": "split_0_train_736_entity",
"type": "progene_text",
"text": [
"Bcl-X(L)"
],
"offsets": [
[
32,
40
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_545 | split_0_train_545 | [
{
"id": "split_0_train_545_passage",
"type": "progene_text",
"text": [
"TG also activated the JNK pathway , which was blocked by L-NAME ."
],
"offsets": [
[
0,
65
]
]
}
]
| [
{
"id": "split_0_train_737_entity",
"type": "progene_text",
"text": [
"JNK"
],
"offsets": [
[
22,
25
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_546 | split_0_train_546 | [
{
"id": "split_0_train_546_passage",
"type": "progene_text",
"text": [
"Transient expression of a dominant negative mutant SEK1 ( Lys --> Arg ) , an upstream kinase of JNK , prevented both TG - induced JNK activation and apoptosis ."
],
"offsets": [
[
0,
160
]
]
}
]
| [
{
"id": "split_0_train_738_entity",
"type": "progene_text",
"text": [
"SEK1"
],
"offsets": [
[
51,
55
]
],
"normalized": []
},
{
"id": "split_0_train_739_entity",
"type": "progene_text",
"text": [
"kinase"
],
"offsets": [
[
86,
92
]
],
"normalized": []
},
{
"id": "split_0_train_740_entity",
"type": "progene_text",
"text": [
"JNK"
],
"offsets": [
[
96,
99
]
],
"normalized": []
},
{
"id": "split_0_train_741_entity",
"type": "progene_text",
"text": [
"JNK"
],
"offsets": [
[
130,
133
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_547 | split_0_train_547 | [
{
"id": "split_0_train_547_passage",
"type": "progene_text",
"text": [
"A dominant negative c-Jun mutant also reduced TG - induced apoptosis ."
],
"offsets": [
[
0,
70
]
]
}
]
| [
{
"id": "split_0_train_742_entity",
"type": "progene_text",
"text": [
"c-Jun"
],
"offsets": [
[
20,
25
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_548 | split_0_train_548 | [
{
"id": "split_0_train_548_passage",
"type": "progene_text",
"text": [
"Overexpression of Bcl-2 or Bcl-X(L) inhibited TG - induced loss in mitochondrial membrane potential , release of cytochrome c , and activation of caspase-3 and JNK ."
],
"offsets": [
[
0,
165
]
]
}
]
| [
{
"id": "split_0_train_743_entity",
"type": "progene_text",
"text": [
"Bcl-2"
],
"offsets": [
[
18,
23
]
],
"normalized": []
},
{
"id": "split_0_train_744_entity",
"type": "progene_text",
"text": [
"Bcl-X(L)"
],
"offsets": [
[
27,
35
]
],
"normalized": []
},
{
"id": "split_0_train_745_entity",
"type": "progene_text",
"text": [
"cytochrome c"
],
"offsets": [
[
113,
125
]
],
"normalized": []
},
{
"id": "split_0_train_746_entity",
"type": "progene_text",
"text": [
"caspase-3"
],
"offsets": [
[
146,
155
]
],
"normalized": []
},
{
"id": "split_0_train_747_entity",
"type": "progene_text",
"text": [
"JNK"
],
"offsets": [
[
160,
163
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_549 | split_0_train_549 | [
{
"id": "split_0_train_549_passage",
"type": "progene_text",
"text": [
"Inhibition of caspase-3 activation blocked TG - induced JNK activation , suggesting that JNK activation occurred downstream of caspase-3 ."
],
"offsets": [
[
0,
138
]
]
}
]
| [
{
"id": "split_0_train_748_entity",
"type": "progene_text",
"text": [
"caspase-3"
],
"offsets": [
[
14,
23
]
],
"normalized": []
},
{
"id": "split_0_train_749_entity",
"type": "progene_text",
"text": [
"JNK"
],
"offsets": [
[
56,
59
]
],
"normalized": []
},
{
"id": "split_0_train_750_entity",
"type": "progene_text",
"text": [
"JNK"
],
"offsets": [
[
89,
92
]
],
"normalized": []
},
{
"id": "split_0_train_751_entity",
"type": "progene_text",
"text": [
"caspase-3"
],
"offsets": [
[
127,
136
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_550 | split_0_train_550 | [
{
"id": "split_0_train_550_passage",
"type": "progene_text",
"text": [
"Thus , TG - induced Ca(2+) release leads to NO generation followed by mitochondrial changes including cytochrome c release and caspase-3 activation ."
],
"offsets": [
[
0,
149
]
]
}
]
| [
{
"id": "split_0_train_752_entity",
"type": "progene_text",
"text": [
"cytochrome c"
],
"offsets": [
[
102,
114
]
],
"normalized": []
},
{
"id": "split_0_train_753_entity",
"type": "progene_text",
"text": [
"caspase-3"
],
"offsets": [
[
127,
136
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_551 | split_0_train_551 | [
{
"id": "split_0_train_551_passage",
"type": "progene_text",
"text": [
"Caspase-3 activation leads to activation of the JNK pathway and apoptosis ."
],
"offsets": [
[
0,
75
]
]
}
]
| [
{
"id": "split_0_train_754_entity",
"type": "progene_text",
"text": [
"Caspase-3"
],
"offsets": [
[
0,
9
]
],
"normalized": []
},
{
"id": "split_0_train_755_entity",
"type": "progene_text",
"text": [
"JNK"
],
"offsets": [
[
48,
51
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_552 | split_0_train_552 | [
{
"id": "split_0_train_552_passage",
"type": "progene_text",
"text": [
"In summary , Ca(2+) - dependent activation of NO production mediates apoptosis after TG exposure in JT / Neo cells ."
],
"offsets": [
[
0,
116
]
]
}
]
| []
| []
| []
| []
|
split_0_train_553 | split_0_train_553 | [
{
"id": "split_0_train_553_passage",
"type": "progene_text",
"text": [
"JT / Bcl-2 and JT / Bcl-X(L) cells are susceptible to NO - mediated apoptosis , but Bcl-2 and Bcl-X(L) protect the cells against TG - induced apoptosis by negatively regulating Ca(2+)-sensitive NO synthase activity or expression ."
],
"offsets": [
[
0,
230
]
]
}
]
| [
{
"id": "split_0_train_756_entity",
"type": "progene_text",
"text": [
"Bcl-2"
],
"offsets": [
[
5,
10
]
],
"normalized": []
},
{
"id": "split_0_train_757_entity",
"type": "progene_text",
"text": [
"Bcl-X(L)"
],
"offsets": [
[
20,
28
]
],
"normalized": []
},
{
"id": "split_0_train_758_entity",
"type": "progene_text",
"text": [
"Bcl-2"
],
"offsets": [
[
84,
89
]
],
"normalized": []
},
{
"id": "split_0_train_759_entity",
"type": "progene_text",
"text": [
"Bcl-X(L)"
],
"offsets": [
[
94,
102
]
],
"normalized": []
},
{
"id": "split_0_train_760_entity",
"type": "progene_text",
"text": [
"NO synthase"
],
"offsets": [
[
194,
205
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_554 | split_0_train_554 | [
{
"id": "split_0_train_554_passage",
"type": "progene_text",
"text": [
"Maternal phenylketonuria : a continuing problem ."
],
"offsets": [
[
0,
49
]
]
}
]
| []
| []
| []
| []
|
split_0_train_555 | split_0_train_555 | [
{
"id": "split_0_train_555_passage",
"type": "progene_text",
"text": [
"OBJECTIVES :"
],
"offsets": [
[
0,
12
]
]
}
]
| []
| []
| []
| []
|
split_0_train_556 | split_0_train_556 | [
{
"id": "split_0_train_556_passage",
"type": "progene_text",
"text": [
"To estimate the number of women of childbearing age in New South Wales whose children are at risk of the maternal phenylketonuria ( PKU ) syndrome ( intellectual disability , microcephaly , congenital malformations ) ."
],
"offsets": [
[
0,
218
]
]
}
]
| []
| []
| []
| []
|
split_0_train_557 | split_0_train_557 | [
{
"id": "split_0_train_557_passage",
"type": "progene_text",
"text": [
"SETTING :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_558 | split_0_train_558 | [
{
"id": "split_0_train_558_passage",
"type": "progene_text",
"text": [
"New South Wales , 1996 ."
],
"offsets": [
[
0,
24
]
]
}
]
| []
| []
| []
| []
|
split_0_train_559 | split_0_train_559 | [
{
"id": "split_0_train_559_passage",
"type": "progene_text",
"text": [
"DESIGN :"
],
"offsets": [
[
0,
8
]
]
}
]
| []
| []
| []
| []
|
split_0_train_560 | split_0_train_560 | [
{
"id": "split_0_train_560_passage",
"type": "progene_text",
"text": [
"Comparison of number of women with PKU aged 15 - 44 years on the NSW PKU database ( observed number ) with expected number derived from population data ."
],
"offsets": [
[
0,
153
]
]
}
]
| []
| []
| []
| []
|
split_0_train_561 | split_0_train_561 | [
{
"id": "split_0_train_561_passage",
"type": "progene_text",
"text": [
"MAIN OUTCOME MEASURES :"
],
"offsets": [
[
0,
23
]
]
}
]
| []
| []
| []
| []
|
split_0_train_562 | split_0_train_562 | [
{
"id": "split_0_train_562_passage",
"type": "progene_text",
"text": [
"Observed and expected numbers of women with PKU ( defined as blood phenylalanine levels > or = 400 mumol / L , and phenylalanine - restricted diet recommended ) by age ; number with no clinical contact with the PKU service in previous year ; outcomes of pregnancies in women with PKU ( January 1994 to July 1996 ) ."
],
"offsets": [
[
0,
315
]
]
}
]
| []
| []
| []
| []
|
split_0_train_563 | split_0_train_563 | [
{
"id": "split_0_train_563_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_564 | split_0_train_564 | [
{
"id": "split_0_train_564_passage",
"type": "progene_text",
"text": [
"110 women aged 15 - 44 years with PKU were listed on the database ."
],
"offsets": [
[
0,
67
]
]
}
]
| []
| []
| []
| []
|
split_0_train_565 | split_0_train_565 | [
{
"id": "split_0_train_565_passage",
"type": "progene_text",
"text": [
"The expected number was 145 ( 95 % confidence interval , 122-171 ) ."
],
"offsets": [
[
0,
68
]
]
}
]
| []
| []
| []
| []
|
split_0_train_566 | split_0_train_566 | [
{
"id": "split_0_train_566_passage",
"type": "progene_text",
"text": [
"The difference was greatest in the 30 - 44 years age group ( born before comprehensive newborn screening ) , with only 55 % of the expected number listed ."
],
"offsets": [
[
0,
155
]
]
}
]
| []
| []
| []
| []
|
split_0_train_567 | split_0_train_567 | [
{
"id": "split_0_train_567_passage",
"type": "progene_text",
"text": [
"Sixteen women who had been diagnosed with PKU at birth were not having regular follow - up , while 18 women had been diagnosed only after investigation of abnormalities in their children ."
],
"offsets": [
[
0,
188
]
]
}
]
| []
| []
| []
| []
|
split_0_train_568 | split_0_train_568 | [
{
"id": "split_0_train_568_passage",
"type": "progene_text",
"text": [
"Of 28 pregnancies managed by the NSW PKU service , 19 were considered unaffected by the maternal PKU syndrome and five affected ( another three did not reach term ; one outcome was unknown ) ."
],
"offsets": [
[
0,
192
]
]
}
]
| []
| []
| []
| []
|
split_0_train_569 | split_0_train_569 | [
{
"id": "split_0_train_569_passage",
"type": "progene_text",
"text": [
"Of 46 unmanaged pregnancies , all were affected ."
],
"offsets": [
[
0,
49
]
]
}
]
| []
| []
| []
| []
|
split_0_train_570 | split_0_train_570 | [
{
"id": "split_0_train_570_passage",
"type": "progene_text",
"text": [
"CONCLUSION :"
],
"offsets": [
[
0,
12
]
]
}
]
| []
| []
| []
| []
|
split_0_train_571 | split_0_train_571 | [
{
"id": "split_0_train_571_passage",
"type": "progene_text",
"text": [
"There is an urgent need for better follow - up of women with PKU and for education of health professionals about the MPKU syndrome , its recognition , the risks of untreated pregnancy and the benefits of dietary treatment ."
],
"offsets": [
[
0,
223
]
]
}
]
| []
| []
| []
| []
|
split_0_train_572 | split_0_train_572 | [
{
"id": "split_0_train_572_passage",
"type": "progene_text",
"text": [
"Multifocal neural conduction impairment in forestry workers exposed and not exposed to vibration ."
],
"offsets": [
[
0,
98
]
]
}
]
| []
| []
| []
| []
|
split_0_train_573 | split_0_train_573 | [
{
"id": "split_0_train_573_passage",
"type": "progene_text",
"text": [
"OBJECTIVE :"
],
"offsets": [
[
0,
11
]
]
}
]
| []
| []
| []
| []
|
split_0_train_574 | split_0_train_574 | [
{
"id": "split_0_train_574_passage",
"type": "progene_text",
"text": [
"The aim of the study was to assess peripheral neural involvement induced by exposure to hand - arm vibration ."
],
"offsets": [
[
0,
110
]
]
}
]
| []
| []
| []
| []
|
split_0_train_575 | split_0_train_575 | [
{
"id": "split_0_train_575_passage",
"type": "progene_text",
"text": [
"METHODS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_576 | split_0_train_576 | [
{
"id": "split_0_train_576_passage",
"type": "progene_text",
"text": [
"Twenty lumberjacks , working regularly with chain - saws and exposed to hand - arm vibration ( group E ) and 20 forestry workers performing heavy manual work and not exposed to vibration ( group NE ) were matched with a control group of 20 healthy non - manual workers ( group C ) ."
],
"offsets": [
[
0,
282
]
]
}
]
| []
| []
| []
| []
|
split_0_train_577 | split_0_train_577 | [
{
"id": "split_0_train_577_passage",
"type": "progene_text",
"text": [
"The subjects of groups E and NE , all symptomatic , and of group C underwent extensive bilateral neurophysiological examination consisting of : sensory conduction ( velocity and amplitude ) of radial , median and ulnar nerves in digit - wrist segments ; sensory conduction ( velocity ) of median nerve in wrist - elbow segment ; mixed conduction ( velocity and amplitude ) of median and ulnar nerves in palm - wrist segments ; motor conduction velocity , including distal motor latencies , and amplitude of median ( elbow - wrist ) and ulnar ( elbow - wrist and across the elbow ) nerves ."
],
"offsets": [
[
0,
589
]
]
}
]
| []
| []
| []
| []
|
split_0_train_578 | split_0_train_578 | [
{
"id": "split_0_train_578_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
]
| []
| []
| []
| []
|
split_0_train_579 | split_0_train_579 | [
{
"id": "split_0_train_579_passage",
"type": "progene_text",
"text": [
"Electrophysiological abnormalities were found in 85 % of group E's limbs , versus 62.5 % of group NE 's limbs ."
],
"offsets": [
[
0,
111
]
]
}
]
| []
| []
| []
| []
|
split_0_train_580 | split_0_train_580 | [
{
"id": "split_0_train_580_passage",
"type": "progene_text",
"text": [
"The most frequent pathological pattern in group E was a ' multifocal ' impairment ( multiple sites of several nerve segments ) , with a prevalent involvement of sensory rather than motor fibres in the hand , seldom extending to the forearm ."
],
"offsets": [
[
0,
241
]
]
}
]
| []
| []
| []
| []
|
split_0_train_581 | split_0_train_581 | [
{
"id": "split_0_train_581_passage",
"type": "progene_text",
"text": [
"Multivariate analysis showed that the neurographic parameters which better characterized workers exposed to hand - arm vibration had a pattern different from that usually found in idiopathic carpal tunnel syndrome ( CTS ) ."
],
"offsets": [
[
0,
223
]
]
}
]
| []
| []
| []
| []
|
split_0_train_582 | split_0_train_582 | [
{
"id": "split_0_train_582_passage",
"type": "progene_text",
"text": [
"CONCLUSION :"
],
"offsets": [
[
0,
12
]
]
}
]
| []
| []
| []
| []
|
split_0_train_583 | split_0_train_583 | [
{
"id": "split_0_train_583_passage",
"type": "progene_text",
"text": [
"These results suggest that vibration - induced neural involvement can be considered neither pure digital neuropathy , nor definite CTS , as previously described ."
],
"offsets": [
[
0,
162
]
]
}
]
| []
| []
| []
| []
|
split_0_train_584 | split_0_train_584 | [
{
"id": "split_0_train_584_passage",
"type": "progene_text",
"text": [
"Preheparin serum lipoprotein lipase mass level : the effects of age , gender , and types of hyperlipidemias ."
],
"offsets": [
[
0,
109
]
]
}
]
| [
{
"id": "split_0_train_761_entity",
"type": "progene_text",
"text": [
"lipoprotein lipase"
],
"offsets": [
[
17,
35
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_585 | split_0_train_585 | [
{
"id": "split_0_train_585_passage",
"type": "progene_text",
"text": [
"To clarify the factors regulating preheparin serum lipoprotein lipase mass ( preheparin LPL mass ) , the correlations between preheparin LPL mass and age , gender and types of hyperlipidemias were investigated in 377 persons who underwent annual health examinations ."
],
"offsets": [
[
0,
267
]
]
}
]
| [
{
"id": "split_0_train_762_entity",
"type": "progene_text",
"text": [
"lipoprotein lipase"
],
"offsets": [
[
51,
69
]
],
"normalized": []
},
{
"id": "split_0_train_763_entity",
"type": "progene_text",
"text": [
"LPL"
],
"offsets": [
[
137,
140
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_586 | split_0_train_586 | [
{
"id": "split_0_train_586_passage",
"type": "progene_text",
"text": [
"Preheparin LPL mass level did not significantly differ in individuals from 19 to 70 years old , for both men and women ."
],
"offsets": [
[
0,
120
]
]
}
]
| [
{
"id": "split_0_train_764_entity",
"type": "progene_text",
"text": [
"LPL"
],
"offsets": [
[
11,
14
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_587 | split_0_train_587 | [
{
"id": "split_0_train_587_passage",
"type": "progene_text",
"text": [
"Preheparin LPL mass level correlated negatively with triglyceride ( TG ) , positively with high density lipoprotein - cholesterol ( HDL - C ) , and not at all with total cholesterol ( TC ) or low density lipoprotein - cholesterol ( LDL - C ) ."
],
"offsets": [
[
0,
243
]
]
}
]
| [
{
"id": "split_0_train_765_entity",
"type": "progene_text",
"text": [
"LPL"
],
"offsets": [
[
11,
14
]
],
"normalized": []
},
{
"id": "split_0_train_766_entity",
"type": "progene_text",
"text": [
"high density lipoprotein"
],
"offsets": [
[
91,
115
]
],
"normalized": []
},
{
"id": "split_0_train_767_entity",
"type": "progene_text",
"text": [
"HDL"
],
"offsets": [
[
132,
135
]
],
"normalized": []
},
{
"id": "split_0_train_768_entity",
"type": "progene_text",
"text": [
"low density lipoprotein"
],
"offsets": [
[
192,
215
]
],
"normalized": []
},
{
"id": "split_0_train_769_entity",
"type": "progene_text",
"text": [
"LDL"
],
"offsets": [
[
232,
235
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_588 | split_0_train_588 | [
{
"id": "split_0_train_588_passage",
"type": "progene_text",
"text": [
"Preheparin LPL mass levels were apparently higher in women than in men , but when serum lipid levels were adjusted , preheparin LPL mass levels were identical ."
],
"offsets": [
[
0,
160
]
]
}
]
| [
{
"id": "split_0_train_770_entity",
"type": "progene_text",
"text": [
"LPL"
],
"offsets": [
[
11,
14
]
],
"normalized": []
},
{
"id": "split_0_train_771_entity",
"type": "progene_text",
"text": [
"LPL"
],
"offsets": [
[
128,
131
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_589 | split_0_train_589 | [
{
"id": "split_0_train_589_passage",
"type": "progene_text",
"text": [
"In type IV and IIb hyperlipidemia , preheparin LPL mass levels were lower than in type IIa patients and in normals ."
],
"offsets": [
[
0,
116
]
]
}
]
| [
{
"id": "split_0_train_772_entity",
"type": "progene_text",
"text": [
"LPL"
],
"offsets": [
[
47,
50
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_590 | split_0_train_590 | [
{
"id": "split_0_train_590_passage",
"type": "progene_text",
"text": [
"Remnant positive individuals had lower levels of preheparin LPL mass than the negative individuals ."
],
"offsets": [
[
0,
100
]
]
}
]
| [
{
"id": "split_0_train_773_entity",
"type": "progene_text",
"text": [
"LPL"
],
"offsets": [
[
60,
63
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_591 | split_0_train_591 | [
{
"id": "split_0_train_591_passage",
"type": "progene_text",
"text": [
"In conclusion , preheparin LPL mass levels were not affected by aging and gender , but were lower in the conditions in which TG catabolism was disturbed , indicating that preheparin LPL mass might reflect somewhat the amount of LPL working in the body ."
],
"offsets": [
[
0,
253
]
]
}
]
| [
{
"id": "split_0_train_774_entity",
"type": "progene_text",
"text": [
"LPL"
],
"offsets": [
[
27,
30
]
],
"normalized": []
},
{
"id": "split_0_train_775_entity",
"type": "progene_text",
"text": [
"LPL"
],
"offsets": [
[
182,
185
]
],
"normalized": []
},
{
"id": "split_0_train_776_entity",
"type": "progene_text",
"text": [
"LPL"
],
"offsets": [
[
228,
231
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_592 | split_0_train_592 | [
{
"id": "split_0_train_592_passage",
"type": "progene_text",
"text": [
"Expression cloning of a human alpha1 , 4-N-acetylglucosaminyltransferase that forms GlcNAcalpha1 --> 4Galbeta --> R , a glycan specifically expressed in the gastric gland mucous cell - type mucin ."
],
"offsets": [
[
0,
197
]
]
}
]
| [
{
"id": "split_0_train_777_entity",
"type": "progene_text",
"text": [
"alpha1 , 4-N-acetylglucosaminyltransferase"
],
"offsets": [
[
30,
72
]
],
"normalized": []
},
{
"id": "split_0_train_778_entity",
"type": "progene_text",
"text": [
"mucin"
],
"offsets": [
[
190,
195
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_593 | split_0_train_593 | [
{
"id": "split_0_train_593_passage",
"type": "progene_text",
"text": [
"Among mucus - secreting cells , the gastric gland mucous cells , Brunner 's glands , accessory glands of pancreaticobiliary tract , and pancreatic ducts exhibiting gastric metaplasia are unique in that they express class III mucin identified by paradoxical Con A staining composed of periodate oxidation , sodium borohydride reduction , Con A , and horseradish peroxidase reaction ."
],
"offsets": [
[
0,
382
]
]
}
]
| [
{
"id": "split_0_train_779_entity",
"type": "progene_text",
"text": [
"class III mucin"
],
"offsets": [
[
215,
230
]
],
"normalized": []
},
{
"id": "split_0_train_780_entity",
"type": "progene_text",
"text": [
"peroxidase"
],
"offsets": [
[
361,
371
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_594 | split_0_train_594 | [
{
"id": "split_0_train_594_passage",
"type": "progene_text",
"text": [
"Recently it was shown that these mucous cells secrete glycoproteins having GlcNAcalpha1 --> 4Galbeta --> R at nonreducing terminals of the carbohydrate moieties ."
],
"offsets": [
[
0,
162
]
]
}
]
| []
| []
| []
| []
|
split_0_train_595 | split_0_train_595 | [
{
"id": "split_0_train_595_passage",
"type": "progene_text",
"text": [
"Herein we describe the expression cloning of a cDNA encoding a human alpha1,4-N-acetylglucosaminyltransferase ( alpha4GnT ) , a key enzyme for the formation of GlcNAcalpha1 --> 4Galbeta1 --> R ."
],
"offsets": [
[
0,
194
]
]
}
]
| [
{
"id": "split_0_train_781_entity",
"type": "progene_text",
"text": [
"alpha1,4-N-acetylglucosaminyltransferase"
],
"offsets": [
[
69,
109
]
],
"normalized": []
},
{
"id": "split_0_train_782_entity",
"type": "progene_text",
"text": [
"alpha4GnT"
],
"offsets": [
[
112,
121
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_596 | split_0_train_596 | [
{
"id": "split_0_train_596_passage",
"type": "progene_text",
"text": [
"COS-1 cells were thus cotransfected with a stomach cDNA library and a leukosialin cDNA ."
],
"offsets": [
[
0,
88
]
]
}
]
| [
{
"id": "split_0_train_783_entity",
"type": "progene_text",
"text": [
"leukosialin"
],
"offsets": [
[
70,
81
]
],
"normalized": []
}
]
| []
| []
| []
|
split_0_train_597 | split_0_train_597 | [
{
"id": "split_0_train_597_passage",
"type": "progene_text",
"text": [
"Transfected COS-1 cells were screened by using monoclonal antibodies specific for GlcNAcalpha1 --> 4Galbeta --> R and enriched by fluorescence - activated cell sorting ."
],
"offsets": [
[
0,
169
]
]
}
]
| []
| []
| []
| []
|
split_0_train_598 | split_0_train_598 | [
{
"id": "split_0_train_598_passage",
"type": "progene_text",
"text": [
"Sibling selection of recovered plasmids resulted in a cDNA clone that directs the expression of GlcNAcalpha1 --> 4Galbeta --> R ."
],
"offsets": [
[
0,
129
]
]
}
]
| []
| []
| []
| []
|
split_0_train_599 | split_0_train_599 | [
{
"id": "split_0_train_599_passage",
"type": "progene_text",
"text": [
"The deduced amino acid sequence predicts a type II membrane protein with 340 amino acids , showing no significant similarity with any other proteins ."
],
"offsets": [
[
0,
150
]
]
}
]
| []
| []
| []
| []
|
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