string: target RNA, the 3’-fragment is predominantly degraded by the nuclear enzyme 5'-3' exoribonuclease 2 (XRN2).(61) Nuclear RNAs including intronic sequences are very vulnerable to cleavage induced by gapmer ASOs,(62-64) and in the context of noncoding RNAs, it was recently observed that ASOs are less sensitive to subcellular localization of their targets while siRNAs tend to be more effective at silencing ncRNAs that are predominantly cytoplasmic.