string: Considerations were based on the AACE Medical Guidelines for Clinical Practice for the Management of Diabetes Mellitus (1), review of other guidelines (ADA Standards of Medical Care in Diabetes—2009) (2), previous algorithms—ACE/AACE Road Maps to Achieve Glycemic Control (10), ADA/EASD 2006 (5,6), ADA/ EASD 2009 (7), Canadian Diabetes Association (8,9), and Inzucchi (11)—the FDA-approved prescribing information for individual agents, pharmacoepidemiologic surveillance studies, and the current literature describing relevant clinical trials: DCCT/EDIC (12), UKPDS (13), Steno-2 (14), ACCORD (15), ADVANCE (16), VADT (17), RECORD (18), PROACTIVE (19), and others.