string: Our results are in agreement with the results of previous in vitro studies [19,31,33,34], demonstrating that, in patients with CHB resistant to both lamivudine and adefovir, a combination of the two drugs was not effective, resulting in a significantly higher rate of early virologic non-response after 6 months of treatment and a significantly poorer virologic response at 12 months compared with entecavir monotherapy, independent of other factors.