string: The absence of telomerase function has been shown to lead to a senescence-associated increase in genome instability in both haploid and diploid strains (Chen and Kolodner, 1999; Hackett et al., 2001; DuBois et al., 2002; Hackett and Greider, 2003; Mieczkowski et al., 2003; Meyer and Bailis, 2007).