H00028.json

{
 "id": "H00028",
 "disease": {
  "id": "H00028",
  "names": [
   "Choriocarcinoma"
  ],
  "dbLinks": {
   "icd10": [
    "C58"
   ],
   "mesh": [
    "D002822"
   ]
  },
  "category": "Cancer"
 },
 "riskFactors": [
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   "text": "maternal age and a history of hydatidiform mole",
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  {
   "text": "uterine size greater than the gestational age",
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  {
   "text": "postmenopausal hormonal replacement, and choriocarcinoma",
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  {
   "text": "high multiparity",
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  {
   "text": "gestational age≥12 weeks",
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  {
   "text": "patients complicated with pih",
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  {
   "text": "patients who had a molar abortion",
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  {
   "text": "women who had used oral contraceptives for at least 5 years",
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  {
   "text": "maternal age and a history of gtd",
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  {
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  {
   "text": "age≥35 years old",
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  {
   "text": "high multiparity and preservation of the uterus after molar abortion",
   "score": 13.048299789428711,
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  {
   "text": "pregnancy induced hypertension (pih)",
   "score": 13.03824234008789,
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  {
   "text": "use of oral contraceptives, postmenopausal hormonal replacement",
   "score": 13.02700138092041,
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  {
   "text": "age superior or equal to 40 years old",
   "score": 13.020907402038574,
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  {
   "text": "age superior or equal to 40 years old, high multiparity",
   "score": 13.012641906738281,
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  {
   "text": "histopathological grade ii-iii",
   "score": 12.998754501342773,
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  {
   "text": "american indian women",
   "score": 12.943901062011719,
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  {
   "text": "low maternal mid-trimester urine hhcg",
   "score": 12.933027267456055,
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  {
   "text": "androgenetic chm",
   "score": 12.773065567016602,
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  {
   "text": "patients with an hm and miscarriages",
   "score": 12.745084762573242,
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  {
   "text": "occupational exposures to fertilizers, phenols, and fumes or smoke",
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  {
   "text": "complete hydatidiform mole (chm)",
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  {
   "text": "disorders of sex development (dsd)",
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  {
   "text": "american indians",
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  {
   "text": "oral contraceptive (oc) use",
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  {
   "text": "necrosis and hemorrhage",
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   "text": "breeding of pigs",
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  {
   "text": "age, ethnicity, and a history of hydatidiform mole",
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  {
   "text": "pregnancy, use of oral contraceptives",
   "score": 12.247268676757812,
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  {
   "text": "patients with ovarian theca-lutein cysts",
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  {
   "text": "pregnancy, use of oral contraceptives, postmenopausal hormonal replacement",
   "score": 12.161247253417969,
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  {
   "text": "fetal wastage",
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  {
   "text": "history of hydatidiform mole or fetal wastage",
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   "text": "long-term oral contraceptive use",
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  {
   "text": "post-term gestation choriocarcinoma",
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  {
   "text": "those with light menstruation",
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   "text": "agricultural workers",
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   "text": "abo blood group interactions",
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   "text": "androgenetic dispermic chm",
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   "text": "ever-users of ocs",
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   "text": "professional occupations",
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   "text": "pregnancy and in particular the puerperium",
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   "text": "menarche after age 12",
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   "text": "age, ethnicity, a history of hydatidiform mole or fetal wastage",
   "score": 11.853704452514648,
   "articlesIDs": [
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  {
   "text": "progressive nuclear atypia",
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  {
   "text": "nurses (sir 7.8; 95% confidence interval 2.1-20) and agricultural workers",
   "score": 11.797704696655273,
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  {
   "text": "prior spontaneous abortions",
   "score": 11.759210586547852,
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  {
   "text": "patients with uterine enlargement beyond that expected for dates",
   "score": 11.73454475402832,
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  {
   "text": "women who started oc before age 20",
   "score": 11.608185768127441,
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  {
   "text": "mean number of months from the last pregnancy to the index pregnancy",
   "score": 11.600716590881348,
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  {
   "text": "prenatal risk factors",
   "score": 11.543821334838867,
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   "text": "maternal age and above third pregnancy",
   "score": 11.522102355957031,
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  {
   "text": "fetal wastage, and abo blood group interactions",
   "score": 11.50758171081543,
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   "text": "complete mole",
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   "text": "increase in maternal age and above third pregnancy",
   "score": 11.448210716247559,
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  {
   "text": "congenital malformation of the male genitalia, prenatal risk factors",
   "score": 11.363595008850098,
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  {
   "text": "low urine hhcg",
   "score": 11.32126522064209,
   "articlesIDs": [
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   "text": "disorders of sex development (dsd), previously referred to as intersex",
   "score": 11.298053741455078,
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  {
   "text": "women of high parity (\u003e or = 5)",
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   "text": "antecedent term pregnancy",
   "score": 11.24782657623291,
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   "text": "excessive production of free beta-subunit of human chorionic gonadotrophin",
   "score": 11.23796558380127,
   "articlesIDs": [
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  {
   "text": "trauma to the testis",
   "score": 11.23794174194336,
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  {
   "text": "gestational trophoblastic disease (gtd)",
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  {
   "text": "previous live births (p = .01). cases were found to eat less meat per wk",
   "score": 11.084964752197266,
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   "text": "american indian women alone",
   "score": 10.948890686035156,
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   "text": "human chorionic gonadotropin normalization times of ≥17 weeks",
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   "text": "cryptorchidism",
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  {
   "text": "cryptorchidism, a prior testicular germ cell tumor",
   "score": 10.695191383361816,
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   "text": "and histopathological grade ii-iii",
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   "text": "o positive",
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  {
   "text": "molar trophoblasts",
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   "text": "family history of testicular germ cell tumors",
   "score": 10.570209503173828,
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   "text": "current users and those who had used hormonal contraceptives (ocs)",
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  {
   "text": "testicular microlithiasis (tm)",
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   "text": "; uterine size greater than the gestational age",
   "score": 10.31929874420166,
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   "text": "trophoblast proliferation",
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  {
   "text": "a complete hydatidiform mole (chm)",
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   "text": "american indian women were",
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   "text": "hyperglycosylated hcg (hhcg)",
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   "text": "time to human chorionic gonadotropin normalization of ≥8 weeks",
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   "text": "an antecedent term pregnancy",
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   "text": "old fertile women",
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   "text": "gestational trophoblastic diseases (gtd)",
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   "text": "infrequent intercourse",
   "score": 10.056549072265625,
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   "text": "post-term gestation \"poor prognosis\" patients",
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   "text": "duration of symptoms for more than 4 months",
   "score": 9.999755859375,
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   "text": "squamous cell carcinoma",
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   "text": "; gestational age≥12 weeks",
   "score": 9.941591262817383,
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  {
   "text": "significant prior unsuccessful chemotherapy or cerebral or hepatic metastases",
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   "text": "the mean number of months from the last pregnancy to the index pregnancy",
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   "text": "patients with pih",
   "score": 9.823003768920898,
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   "text": "resident at wittenoom",
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   "text": "partial hydatidiform mole (phm)",
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   "text": "cryptorchidism and antecedent contralateral testicular tumor formation",
   "score": 9.728759765625,
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   "text": "below normal estrogen levels",
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   "text": "those who had used hormonal contraceptives (ocs) within 10 years",
   "score": 9.700645446777344,
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  {
   "text": "adenosquamous carcinoma, squamous cell carcinoma",
   "score": 9.603195190429688,
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   "text": "hormonal factors, specifically below normal estrogen levels",
   "score": 9.539989471435547,
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   "text": "cerebral venous thrombosis during pregnancy or the puerperium",
   "score": 9.502035140991211,
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   "text": "women who had first been exposed to asbestos as young girls",
   "score": 9.501214027404785,
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   "text": "with the breeding of pigs",
   "score": 9.494789123535156,
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   "text": "common genetic female germline defects",
   "score": 9.458785057067871,
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   "text": "male infertility",
   "score": 9.448554992675781,
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   "text": "genetic instability found in the molar trophoblasts",
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   "text": "adenosquamous carcinoma, squamous cell carcinoma and mixed mullerian tumour",
   "score": 9.363037109375,
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   "text": "synthetic estrogens and progestins",
   "score": 9.35532283782959,
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   "text": "history of hydatidiform mole, medical factors, drug usage",
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   "text": "for women who had used oral contraceptives for at least 5 years",
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  {
   "text": "prenatal risk factors, nonspecific and specific exposures in adulthood",
   "score": 9.034749031066895,
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   "text": "a family history of testicular germ cell tumors",
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   "text": "with increase in maternal age and above third pregnancy",
   "score": 8.97486686706543,
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   "text": "traits associated with exposure of the testis to heat",
   "score": 8.910087585449219,
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  {
   "text": "women who have had widespread gtd including cerebral metastases",
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   "text": "age of ≥45 years",
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   "text": "healthy pregnant women",
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  {
   "text": "patients with adenocarcinoma, adenosquamous carcinoma",
   "score": 8.628313064575195,
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  {
   "text": "low sperm count, fertility problems, atrophic testis, and cryptorchidism",
   "score": 8.558091163635254,
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  {
   "text": "following a complete hydatidiform mole (chm)",
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   "text": "decreased trophoblast maturation",
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   "text": "the complete mole",
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  {
   "text": "complicated with pregnancy induced hypertension (pih)",
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  {
   "text": "previous pregnancy outcomes",
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 ]
}