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README.md

@@ -15,7 +15,7 @@ An illustration of aligning sequences with sequence-to-sequence learning. (a) Co
 
 We used SpartaABC (Loewenthal et al., 2021) to generate millions of true alignments. SpartaABC requires the following input: (1) a rooted phylogenetic tree, which includes a topology and branch lengths; (2) a substitution model (amino acids or nucleotides); (3) root sequence length; (4) the indel model parameters, which include: insertion rate (*R_I*), deletion rate (*R_D*), a parameter for the insertion Zipfian distribution (*A_I*), and a parameter for the deletion Zipfian distribution (*A_D*). MSAs were simulated along random phylogenetic tree topologies generated using the program ETE version 3.0 (Huerta-Cepas et al., 2016) with default parameters.
 
-We generated 1,495,000, 2,000 and 3,000,  protein MSAs with ten sequences that were used as training validation and testing data, respectively. We generated the same number of DNA MSAs. For each random tree, branch lengths were drawn from a uniform distribution in the range *(0.5,1.0)*. Next, the sequences were generated using SpartaABC with the following parameters: *R_I,R_D \in (0.0,0.05)*, *A_I, A_D \in (1.01,2.0)*. The alignment lengths as well as the sequence lengths of the tree leaves vary within and among datasets as they depend on the indel dynamics and the root length. The root length was sampled uniformly in the range *[32,44]*. Unless stated otherwise, all protein datasets were generated with the WAG+G model, and all DNA datasets were generated with the GTR+G model, with the following parameters: (1) frequencies for the different nucleotides $(0.37, 0.166, 0.307, 0.158)$, in the order "T", "C", "A" and ``G"; (2) with the substitutions rate *(0.444, 0.0843, 0.116, 0.107, 0.00027)*, in the order "a", "b", "c", "d", and "e" for the substitution matrix.
+We generated 1,495,000, 2,000 and 3,000,  protein MSAs with ten sequences that were used as training validation and testing data, respectively. We generated the same number of DNA MSAs. For each random tree, branch lengths were drawn from a uniform distribution in the range *(0.5,1.0)*. Next, the sequences were generated using SpartaABC with the following parameters: *R_I,R_D \in (0.0,0.05)*, *A_I, A_D \in (1.01,2.0)*. The alignment lengths as well as the sequence lengths of the tree leaves vary within and among datasets as they depend on the indel dynamics and the root length. The root length was sampled uniformly in the range *[32,44]*. Unless stated otherwise, all protein datasets were generated with the WAG+G model, and all DNA datasets were generated with the GTR+G model, with the following parameters: (1) frequencies for the different nucleotides *(0.37, 0.166, 0.307, 0.158)*, in the order "T", "C", "A" and "G"; (2) with the substitutions rate *(0.444, 0.0843, 0.116, 0.107, 0.00027)*, in the order "a", "b", "c", "d", and "e" for the substitution matrix.
 
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